data_8VYY
# 
_entry.id   8VYY 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8VYY         pdb_00008vyy 10.2210/pdb8vyy/pdb 
WWPDB D_1000281454 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8VYY 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              feradical@utsa.edu 
_pdbx_contact_author.name_first         Aimin 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-4182-8176 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Shin, I.' 1 0000-0001-8111-8948 
'Liu, A.'  2 0000-0002-4182-8176 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Biol.Chem. 
_citation.journal_id_ASTM           JBCHA3 
_citation.journal_id_CSD            0071 
_citation.journal_id_ISSN           1083-351X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            301 
_citation.language                  ? 
_citation.page_first                108241 
_citation.page_last                 108241 
_citation.title                     
;Structural insights into 2-oxindole-forming monooxygenase MarE: Divergent architecture and substrate positioning versus tryptophan dioxygenases.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.jbc.2025.108241 
_citation.pdbx_database_id_PubMed   39880093 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Shin, I.'      1 ? 
primary 'Nguyen, R.C.'  2 ? 
primary 'Montoya, S.R.' 3 ? 
primary 'Liu, A.'       4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Tryptophan 2,3-dioxygenase'       30590.178 2  ? ? ? ? 
2 non-polymer syn 'PROTOPORPHYRIN IX CONTAINING FE'  616.487   2  ? ? ? ? 
3 non-polymer nat '(betaS)-beta-methyl-L-tryptophan' 218.252   2  ? ? ? ? 
4 water       nat water                              18.015    92 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GHMKRSLNPDEPNALLSYDFDRGSNYENVLHLTDALGALVPESETEHPDQRFFQVTHLITEYAWVQVHYELRRAIGHLDE
DRYHQAVRMFDRATGLSEVTVQAVRLLTDHLPQHSLLMMRNALPEDATGLDSPGYRNLRRVARPVWKAYEQAVERAGLSL
QDVIAQQDDGYDGPRSGGSQSLALVREAMLRLDGSVLGWKQHHLIMVWSQLGGQPGLRKGNEEGDDGLELPQSLGGRSLA
TLEARSQLALFPELWRAAEDAYWLLGTRHDT
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GHMKRSLNPDEPNALLSYDFDRGSNYENVLHLTDALGALVPESETEHPDQRFFQVTHLITEYAWVQVHYELRRAIGHLDE
DRYHQAVRMFDRATGLSEVTVQAVRLLTDHLPQHSLLMMRNALPEDATGLDSPGYRNLRRVARPVWKAYEQAVERAGLSL
QDVIAQQDDGYDGPRSGGSQSLALVREAMLRLDGSVLGWKQHHLIMVWSQLGGQPGLRKGNEEGDDGLELPQSLGGRSLA
TLEARSQLALFPELWRAAEDAYWLLGTRHDT
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PROTOPORPHYRIN IX CONTAINING FE'  HEM 
3 '(betaS)-beta-methyl-L-tryptophan' 78U 
4 water                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   HIS n 
1 3   MET n 
1 4   LYS n 
1 5   ARG n 
1 6   SER n 
1 7   LEU n 
1 8   ASN n 
1 9   PRO n 
1 10  ASP n 
1 11  GLU n 
1 12  PRO n 
1 13  ASN n 
1 14  ALA n 
1 15  LEU n 
1 16  LEU n 
1 17  SER n 
1 18  TYR n 
1 19  ASP n 
1 20  PHE n 
1 21  ASP n 
1 22  ARG n 
1 23  GLY n 
1 24  SER n 
1 25  ASN n 
1 26  TYR n 
1 27  GLU n 
1 28  ASN n 
1 29  VAL n 
1 30  LEU n 
1 31  HIS n 
1 32  LEU n 
1 33  THR n 
1 34  ASP n 
1 35  ALA n 
1 36  LEU n 
1 37  GLY n 
1 38  ALA n 
1 39  LEU n 
1 40  VAL n 
1 41  PRO n 
1 42  GLU n 
1 43  SER n 
1 44  GLU n 
1 45  THR n 
1 46  GLU n 
1 47  HIS n 
1 48  PRO n 
1 49  ASP n 
1 50  GLN n 
1 51  ARG n 
1 52  PHE n 
1 53  PHE n 
1 54  GLN n 
1 55  VAL n 
1 56  THR n 
1 57  HIS n 
1 58  LEU n 
1 59  ILE n 
1 60  THR n 
1 61  GLU n 
1 62  TYR n 
1 63  ALA n 
1 64  TRP n 
1 65  VAL n 
1 66  GLN n 
1 67  VAL n 
1 68  HIS n 
1 69  TYR n 
1 70  GLU n 
1 71  LEU n 
1 72  ARG n 
1 73  ARG n 
1 74  ALA n 
1 75  ILE n 
1 76  GLY n 
1 77  HIS n 
1 78  LEU n 
1 79  ASP n 
1 80  GLU n 
1 81  ASP n 
1 82  ARG n 
1 83  TYR n 
1 84  HIS n 
1 85  GLN n 
1 86  ALA n 
1 87  VAL n 
1 88  ARG n 
1 89  MET n 
1 90  PHE n 
1 91  ASP n 
1 92  ARG n 
1 93  ALA n 
1 94  THR n 
1 95  GLY n 
1 96  LEU n 
1 97  SER n 
1 98  GLU n 
1 99  VAL n 
1 100 THR n 
1 101 VAL n 
1 102 GLN n 
1 103 ALA n 
1 104 VAL n 
1 105 ARG n 
1 106 LEU n 
1 107 LEU n 
1 108 THR n 
1 109 ASP n 
1 110 HIS n 
1 111 LEU n 
1 112 PRO n 
1 113 GLN n 
1 114 HIS n 
1 115 SER n 
1 116 LEU n 
1 117 LEU n 
1 118 MET n 
1 119 MET n 
1 120 ARG n 
1 121 ASN n 
1 122 ALA n 
1 123 LEU n 
1 124 PRO n 
1 125 GLU n 
1 126 ASP n 
1 127 ALA n 
1 128 THR n 
1 129 GLY n 
1 130 LEU n 
1 131 ASP n 
1 132 SER n 
1 133 PRO n 
1 134 GLY n 
1 135 TYR n 
1 136 ARG n 
1 137 ASN n 
1 138 LEU n 
1 139 ARG n 
1 140 ARG n 
1 141 VAL n 
1 142 ALA n 
1 143 ARG n 
1 144 PRO n 
1 145 VAL n 
1 146 TRP n 
1 147 LYS n 
1 148 ALA n 
1 149 TYR n 
1 150 GLU n 
1 151 GLN n 
1 152 ALA n 
1 153 VAL n 
1 154 GLU n 
1 155 ARG n 
1 156 ALA n 
1 157 GLY n 
1 158 LEU n 
1 159 SER n 
1 160 LEU n 
1 161 GLN n 
1 162 ASP n 
1 163 VAL n 
1 164 ILE n 
1 165 ALA n 
1 166 GLN n 
1 167 GLN n 
1 168 ASP n 
1 169 ASP n 
1 170 GLY n 
1 171 TYR n 
1 172 ASP n 
1 173 GLY n 
1 174 PRO n 
1 175 ARG n 
1 176 SER n 
1 177 GLY n 
1 178 GLY n 
1 179 SER n 
1 180 GLN n 
1 181 SER n 
1 182 LEU n 
1 183 ALA n 
1 184 LEU n 
1 185 VAL n 
1 186 ARG n 
1 187 GLU n 
1 188 ALA n 
1 189 MET n 
1 190 LEU n 
1 191 ARG n 
1 192 LEU n 
1 193 ASP n 
1 194 GLY n 
1 195 SER n 
1 196 VAL n 
1 197 LEU n 
1 198 GLY n 
1 199 TRP n 
1 200 LYS n 
1 201 GLN n 
1 202 HIS n 
1 203 HIS n 
1 204 LEU n 
1 205 ILE n 
1 206 MET n 
1 207 VAL n 
1 208 TRP n 
1 209 SER n 
1 210 GLN n 
1 211 LEU n 
1 212 GLY n 
1 213 GLY n 
1 214 GLN n 
1 215 PRO n 
1 216 GLY n 
1 217 LEU n 
1 218 ARG n 
1 219 LYS n 
1 220 GLY n 
1 221 ASN n 
1 222 GLU n 
1 223 GLU n 
1 224 GLY n 
1 225 ASP n 
1 226 ASP n 
1 227 GLY n 
1 228 LEU n 
1 229 GLU n 
1 230 LEU n 
1 231 PRO n 
1 232 GLN n 
1 233 SER n 
1 234 LEU n 
1 235 GLY n 
1 236 GLY n 
1 237 ARG n 
1 238 SER n 
1 239 LEU n 
1 240 ALA n 
1 241 THR n 
1 242 LEU n 
1 243 GLU n 
1 244 ALA n 
1 245 ARG n 
1 246 SER n 
1 247 GLN n 
1 248 LEU n 
1 249 ALA n 
1 250 LEU n 
1 251 PHE n 
1 252 PRO n 
1 253 GLU n 
1 254 LEU n 
1 255 TRP n 
1 256 ARG n 
1 257 ALA n 
1 258 ALA n 
1 259 GLU n 
1 260 ASP n 
1 261 ALA n 
1 262 TYR n 
1 263 TRP n 
1 264 LEU n 
1 265 LEU n 
1 266 GLY n 
1 267 THR n 
1 268 ARG n 
1 269 HIS n 
1 270 ASP n 
1 271 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   271 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 marE 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces sp.' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1931 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
78U non-polymer         . '(betaS)-beta-methyl-L-tryptophan' ?    'C12 H14 N2 O2'    218.252 
ALA 'L-peptide linking' y ALANINE                            ?    'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                           ?    'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                         ?    'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                    ?    'C4 H7 N O4'       133.103 
GLN 'L-peptide linking' y GLUTAMINE                          ?    'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                    ?    'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                            ?    'C2 H5 N O2'       75.067  
HEM non-polymer         . 'PROTOPORPHYRIN IX CONTAINING FE'  HEME 'C34 H32 Fe N4 O4' 616.487 
HIS 'L-peptide linking' y HISTIDINE                          ?    'C6 H10 N3 O2 1'   156.162 
HOH non-polymer         . WATER                              ?    'H2 O'             18.015  
ILE 'L-peptide linking' y ISOLEUCINE                         ?    'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                            ?    'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                             ?    'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE                         ?    'C5 H11 N O2 S'    149.211 
PHE 'L-peptide linking' y PHENYLALANINE                      ?    'C9 H11 N O2'      165.189 
PRO 'L-peptide linking' y PROLINE                            ?    'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                             ?    'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                          ?    'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                         ?    'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                           ?    'C9 H11 N O3'      181.189 
VAL 'L-peptide linking' y VALINE                             ?    'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -1  ?   ?   ?   A . n 
A 1 2   HIS 2   0   ?   ?   ?   A . n 
A 1 3   MET 3   1   ?   ?   ?   A . n 
A 1 4   LYS 4   2   ?   ?   ?   A . n 
A 1 5   ARG 5   3   ?   ?   ?   A . n 
A 1 6   SER 6   4   4   SER SER A . n 
A 1 7   LEU 7   5   5   LEU LEU A . n 
A 1 8   ASN 8   6   6   ASN ASN A . n 
A 1 9   PRO 9   7   7   PRO PRO A . n 
A 1 10  ASP 10  8   8   ASP ASP A . n 
A 1 11  GLU 11  9   9   GLU GLU A . n 
A 1 12  PRO 12  10  10  PRO PRO A . n 
A 1 13  ASN 13  11  11  ASN ASN A . n 
A 1 14  ALA 14  12  12  ALA ALA A . n 
A 1 15  LEU 15  13  13  LEU LEU A . n 
A 1 16  LEU 16  14  14  LEU LEU A . n 
A 1 17  SER 17  15  15  SER SER A . n 
A 1 18  TYR 18  16  16  TYR TYR A . n 
A 1 19  ASP 19  17  17  ASP ASP A . n 
A 1 20  PHE 20  18  18  PHE PHE A . n 
A 1 21  ASP 21  19  19  ASP ASP A . n 
A 1 22  ARG 22  20  20  ARG ARG A . n 
A 1 23  GLY 23  21  21  GLY GLY A . n 
A 1 24  SER 24  22  22  SER SER A . n 
A 1 25  ASN 25  23  23  ASN ASN A . n 
A 1 26  TYR 26  24  24  TYR TYR A . n 
A 1 27  GLU 27  25  25  GLU GLU A . n 
A 1 28  ASN 28  26  26  ASN ASN A . n 
A 1 29  VAL 29  27  27  VAL VAL A . n 
A 1 30  LEU 30  28  28  LEU LEU A . n 
A 1 31  HIS 31  29  29  HIS HIS A . n 
A 1 32  LEU 32  30  30  LEU LEU A . n 
A 1 33  THR 33  31  31  THR THR A . n 
A 1 34  ASP 34  32  32  ASP ASP A . n 
A 1 35  ALA 35  33  33  ALA ALA A . n 
A 1 36  LEU 36  34  34  LEU LEU A . n 
A 1 37  GLY 37  35  35  GLY GLY A . n 
A 1 38  ALA 38  36  36  ALA ALA A . n 
A 1 39  LEU 39  37  37  LEU LEU A . n 
A 1 40  VAL 40  38  38  VAL VAL A . n 
A 1 41  PRO 41  39  39  PRO PRO A . n 
A 1 42  GLU 42  40  40  GLU GLU A . n 
A 1 43  SER 43  41  41  SER SER A . n 
A 1 44  GLU 44  42  42  GLU GLU A . n 
A 1 45  THR 45  43  43  THR THR A . n 
A 1 46  GLU 46  44  44  GLU GLU A . n 
A 1 47  HIS 47  45  45  HIS HIS A . n 
A 1 48  PRO 48  46  46  PRO PRO A . n 
A 1 49  ASP 49  47  47  ASP ASP A . n 
A 1 50  GLN 50  48  48  GLN GLN A . n 
A 1 51  ARG 51  49  49  ARG ARG A . n 
A 1 52  PHE 52  50  50  PHE PHE A . n 
A 1 53  PHE 53  51  51  PHE PHE A . n 
A 1 54  GLN 54  52  52  GLN GLN A . n 
A 1 55  VAL 55  53  53  VAL VAL A . n 
A 1 56  THR 56  54  54  THR THR A . n 
A 1 57  HIS 57  55  55  HIS HIS A . n 
A 1 58  LEU 58  56  56  LEU LEU A . n 
A 1 59  ILE 59  57  57  ILE ILE A . n 
A 1 60  THR 60  58  58  THR THR A . n 
A 1 61  GLU 61  59  59  GLU GLU A . n 
A 1 62  TYR 62  60  60  TYR TYR A . n 
A 1 63  ALA 63  61  61  ALA ALA A . n 
A 1 64  TRP 64  62  62  TRP TRP A . n 
A 1 65  VAL 65  63  63  VAL VAL A . n 
A 1 66  GLN 66  64  64  GLN GLN A . n 
A 1 67  VAL 67  65  65  VAL VAL A . n 
A 1 68  HIS 68  66  66  HIS HIS A . n 
A 1 69  TYR 69  67  67  TYR TYR A . n 
A 1 70  GLU 70  68  68  GLU GLU A . n 
A 1 71  LEU 71  69  69  LEU LEU A . n 
A 1 72  ARG 72  70  70  ARG ARG A . n 
A 1 73  ARG 73  71  71  ARG ARG A . n 
A 1 74  ALA 74  72  72  ALA ALA A . n 
A 1 75  ILE 75  73  73  ILE ILE A . n 
A 1 76  GLY 76  74  74  GLY GLY A . n 
A 1 77  HIS 77  75  75  HIS HIS A . n 
A 1 78  LEU 78  76  76  LEU LEU A . n 
A 1 79  ASP 79  77  77  ASP ASP A . n 
A 1 80  GLU 80  78  78  GLU GLU A . n 
A 1 81  ASP 81  79  79  ASP ASP A . n 
A 1 82  ARG 82  80  80  ARG ARG A . n 
A 1 83  TYR 83  81  81  TYR TYR A . n 
A 1 84  HIS 84  82  82  HIS HIS A . n 
A 1 85  GLN 85  83  83  GLN GLN A . n 
A 1 86  ALA 86  84  84  ALA ALA A . n 
A 1 87  VAL 87  85  85  VAL VAL A . n 
A 1 88  ARG 88  86  86  ARG ARG A . n 
A 1 89  MET 89  87  87  MET MET A . n 
A 1 90  PHE 90  88  88  PHE PHE A . n 
A 1 91  ASP 91  89  89  ASP ASP A . n 
A 1 92  ARG 92  90  90  ARG ARG A . n 
A 1 93  ALA 93  91  91  ALA ALA A . n 
A 1 94  THR 94  92  92  THR THR A . n 
A 1 95  GLY 95  93  93  GLY GLY A . n 
A 1 96  LEU 96  94  94  LEU LEU A . n 
A 1 97  SER 97  95  95  SER SER A . n 
A 1 98  GLU 98  96  96  GLU GLU A . n 
A 1 99  VAL 99  97  97  VAL VAL A . n 
A 1 100 THR 100 98  98  THR THR A . n 
A 1 101 VAL 101 99  99  VAL VAL A . n 
A 1 102 GLN 102 100 100 GLN GLN A . n 
A 1 103 ALA 103 101 101 ALA ALA A . n 
A 1 104 VAL 104 102 102 VAL VAL A . n 
A 1 105 ARG 105 103 103 ARG ARG A . n 
A 1 106 LEU 106 104 104 LEU LEU A . n 
A 1 107 LEU 107 105 105 LEU LEU A . n 
A 1 108 THR 108 106 106 THR THR A . n 
A 1 109 ASP 109 107 107 ASP ASP A . n 
A 1 110 HIS 110 108 108 HIS HIS A . n 
A 1 111 LEU 111 109 109 LEU LEU A . n 
A 1 112 PRO 112 110 110 PRO PRO A . n 
A 1 113 GLN 113 111 111 GLN GLN A . n 
A 1 114 HIS 114 112 112 HIS HIS A . n 
A 1 115 SER 115 113 113 SER SER A . n 
A 1 116 LEU 116 114 114 LEU LEU A . n 
A 1 117 LEU 117 115 115 LEU LEU A . n 
A 1 118 MET 118 116 116 MET MET A . n 
A 1 119 MET 119 117 117 MET MET A . n 
A 1 120 ARG 120 118 118 ARG ARG A . n 
A 1 121 ASN 121 119 119 ASN ASN A . n 
A 1 122 ALA 122 120 120 ALA ALA A . n 
A 1 123 LEU 123 121 121 LEU LEU A . n 
A 1 124 PRO 124 122 122 PRO PRO A . n 
A 1 125 GLU 125 123 123 GLU GLU A . n 
A 1 126 ASP 126 124 124 ASP ASP A . n 
A 1 127 ALA 127 125 125 ALA ALA A . n 
A 1 128 THR 128 126 126 THR THR A . n 
A 1 129 GLY 129 127 127 GLY GLY A . n 
A 1 130 LEU 130 128 128 LEU LEU A . n 
A 1 131 ASP 131 129 129 ASP ASP A . n 
A 1 132 SER 132 130 130 SER SER A . n 
A 1 133 PRO 133 131 131 PRO PRO A . n 
A 1 134 GLY 134 132 132 GLY GLY A . n 
A 1 135 TYR 135 133 133 TYR TYR A . n 
A 1 136 ARG 136 134 134 ARG ARG A . n 
A 1 137 ASN 137 135 135 ASN ASN A . n 
A 1 138 LEU 138 136 136 LEU LEU A . n 
A 1 139 ARG 139 137 137 ARG ARG A . n 
A 1 140 ARG 140 138 138 ARG ARG A . n 
A 1 141 VAL 141 139 139 VAL VAL A . n 
A 1 142 ALA 142 140 140 ALA ALA A . n 
A 1 143 ARG 143 141 141 ARG ARG A . n 
A 1 144 PRO 144 142 142 PRO PRO A . n 
A 1 145 VAL 145 143 143 VAL VAL A . n 
A 1 146 TRP 146 144 144 TRP TRP A . n 
A 1 147 LYS 147 145 145 LYS LYS A . n 
A 1 148 ALA 148 146 146 ALA ALA A . n 
A 1 149 TYR 149 147 147 TYR TYR A . n 
A 1 150 GLU 150 148 148 GLU GLU A . n 
A 1 151 GLN 151 149 149 GLN GLN A . n 
A 1 152 ALA 152 150 150 ALA ALA A . n 
A 1 153 VAL 153 151 151 VAL VAL A . n 
A 1 154 GLU 154 152 152 GLU GLU A . n 
A 1 155 ARG 155 153 153 ARG ARG A . n 
A 1 156 ALA 156 154 154 ALA ALA A . n 
A 1 157 GLY 157 155 155 GLY GLY A . n 
A 1 158 LEU 158 156 156 LEU LEU A . n 
A 1 159 SER 159 157 157 SER SER A . n 
A 1 160 LEU 160 158 158 LEU LEU A . n 
A 1 161 GLN 161 159 159 GLN GLN A . n 
A 1 162 ASP 162 160 160 ASP ASP A . n 
A 1 163 VAL 163 161 161 VAL VAL A . n 
A 1 164 ILE 164 162 162 ILE ILE A . n 
A 1 165 ALA 165 163 163 ALA ALA A . n 
A 1 166 GLN 166 164 164 GLN GLN A . n 
A 1 167 GLN 167 165 165 GLN GLN A . n 
A 1 168 ASP 168 166 166 ASP ASP A . n 
A 1 169 ASP 169 167 167 ASP ASP A . n 
A 1 170 GLY 170 168 168 GLY GLY A . n 
A 1 171 TYR 171 169 169 TYR TYR A . n 
A 1 172 ASP 172 170 170 ASP ASP A . n 
A 1 173 GLY 173 171 171 GLY GLY A . n 
A 1 174 PRO 174 172 172 PRO PRO A . n 
A 1 175 ARG 175 173 173 ARG ARG A . n 
A 1 176 SER 176 174 174 SER SER A . n 
A 1 177 GLY 177 175 175 GLY GLY A . n 
A 1 178 GLY 178 176 176 GLY GLY A . n 
A 1 179 SER 179 177 177 SER SER A . n 
A 1 180 GLN 180 178 178 GLN GLN A . n 
A 1 181 SER 181 179 179 SER SER A . n 
A 1 182 LEU 182 180 180 LEU LEU A . n 
A 1 183 ALA 183 181 181 ALA ALA A . n 
A 1 184 LEU 184 182 182 LEU LEU A . n 
A 1 185 VAL 185 183 183 VAL VAL A . n 
A 1 186 ARG 186 184 184 ARG ARG A . n 
A 1 187 GLU 187 185 185 GLU GLU A . n 
A 1 188 ALA 188 186 186 ALA ALA A . n 
A 1 189 MET 189 187 187 MET MET A . n 
A 1 190 LEU 190 188 188 LEU LEU A . n 
A 1 191 ARG 191 189 189 ARG ARG A . n 
A 1 192 LEU 192 190 190 LEU LEU A . n 
A 1 193 ASP 193 191 191 ASP ASP A . n 
A 1 194 GLY 194 192 192 GLY GLY A . n 
A 1 195 SER 195 193 193 SER SER A . n 
A 1 196 VAL 196 194 194 VAL VAL A . n 
A 1 197 LEU 197 195 195 LEU LEU A . n 
A 1 198 GLY 198 196 196 GLY GLY A . n 
A 1 199 TRP 199 197 197 TRP TRP A . n 
A 1 200 LYS 200 198 198 LYS LYS A . n 
A 1 201 GLN 201 199 199 GLN GLN A . n 
A 1 202 HIS 202 200 200 HIS HIS A . n 
A 1 203 HIS 203 201 201 HIS HIS A . n 
A 1 204 LEU 204 202 202 LEU LEU A . n 
A 1 205 ILE 205 203 203 ILE ILE A . n 
A 1 206 MET 206 204 204 MET MET A . n 
A 1 207 VAL 207 205 205 VAL VAL A . n 
A 1 208 TRP 208 206 206 TRP TRP A . n 
A 1 209 SER 209 207 207 SER SER A . n 
A 1 210 GLN 210 208 208 GLN GLN A . n 
A 1 211 LEU 211 209 209 LEU LEU A . n 
A 1 212 GLY 212 210 210 GLY GLY A . n 
A 1 213 GLY 213 211 211 GLY GLY A . n 
A 1 214 GLN 214 212 212 GLN GLN A . n 
A 1 215 PRO 215 213 213 PRO PRO A . n 
A 1 216 GLY 216 214 214 GLY GLY A . n 
A 1 217 LEU 217 215 215 LEU LEU A . n 
A 1 218 ARG 218 216 216 ARG ARG A . n 
A 1 219 LYS 219 217 ?   ?   ?   A . n 
A 1 220 GLY 220 218 ?   ?   ?   A . n 
A 1 221 ASN 221 219 ?   ?   ?   A . n 
A 1 222 GLU 222 220 ?   ?   ?   A . n 
A 1 223 GLU 223 221 ?   ?   ?   A . n 
A 1 224 GLY 224 222 ?   ?   ?   A . n 
A 1 225 ASP 225 223 ?   ?   ?   A . n 
A 1 226 ASP 226 224 ?   ?   ?   A . n 
A 1 227 GLY 227 225 ?   ?   ?   A . n 
A 1 228 LEU 228 226 ?   ?   ?   A . n 
A 1 229 GLU 229 227 ?   ?   ?   A . n 
A 1 230 LEU 230 228 ?   ?   ?   A . n 
A 1 231 PRO 231 229 ?   ?   ?   A . n 
A 1 232 GLN 232 230 ?   ?   ?   A . n 
A 1 233 SER 233 231 ?   ?   ?   A . n 
A 1 234 LEU 234 232 ?   ?   ?   A . n 
A 1 235 GLY 235 233 ?   ?   ?   A . n 
A 1 236 GLY 236 234 ?   ?   ?   A . n 
A 1 237 ARG 237 235 235 ARG ARG A . n 
A 1 238 SER 238 236 236 SER SER A . n 
A 1 239 LEU 239 237 237 LEU LEU A . n 
A 1 240 ALA 240 238 238 ALA ALA A . n 
A 1 241 THR 241 239 239 THR THR A . n 
A 1 242 LEU 242 240 240 LEU LEU A . n 
A 1 243 GLU 243 241 241 GLU GLU A . n 
A 1 244 ALA 244 242 242 ALA ALA A . n 
A 1 245 ARG 245 243 243 ARG ARG A . n 
A 1 246 SER 246 244 244 SER SER A . n 
A 1 247 GLN 247 245 245 GLN GLN A . n 
A 1 248 LEU 248 246 246 LEU LEU A . n 
A 1 249 ALA 249 247 247 ALA ALA A . n 
A 1 250 LEU 250 248 248 LEU LEU A . n 
A 1 251 PHE 251 249 249 PHE PHE A . n 
A 1 252 PRO 252 250 250 PRO PRO A . n 
A 1 253 GLU 253 251 251 GLU GLU A . n 
A 1 254 LEU 254 252 252 LEU LEU A . n 
A 1 255 TRP 255 253 253 TRP TRP A . n 
A 1 256 ARG 256 254 254 ARG ARG A . n 
A 1 257 ALA 257 255 255 ALA ALA A . n 
A 1 258 ALA 258 256 256 ALA ALA A . n 
A 1 259 GLU 259 257 257 GLU GLU A . n 
A 1 260 ASP 260 258 258 ASP ASP A . n 
A 1 261 ALA 261 259 259 ALA ALA A . n 
A 1 262 TYR 262 260 260 TYR TYR A . n 
A 1 263 TRP 263 261 261 TRP TRP A . n 
A 1 264 LEU 264 262 262 LEU LEU A . n 
A 1 265 LEU 265 263 263 LEU LEU A . n 
A 1 266 GLY 266 264 264 GLY GLY A . n 
A 1 267 THR 267 265 265 THR THR A . n 
A 1 268 ARG 268 266 ?   ?   ?   A . n 
A 1 269 HIS 269 267 ?   ?   ?   A . n 
A 1 270 ASP 270 268 ?   ?   ?   A . n 
A 1 271 THR 271 269 ?   ?   ?   A . n 
B 1 1   GLY 1   -1  ?   ?   ?   B . n 
B 1 2   HIS 2   0   ?   ?   ?   B . n 
B 1 3   MET 3   1   ?   ?   ?   B . n 
B 1 4   LYS 4   2   ?   ?   ?   B . n 
B 1 5   ARG 5   3   ?   ?   ?   B . n 
B 1 6   SER 6   4   4   SER SER B . n 
B 1 7   LEU 7   5   5   LEU LEU B . n 
B 1 8   ASN 8   6   6   ASN ASN B . n 
B 1 9   PRO 9   7   7   PRO PRO B . n 
B 1 10  ASP 10  8   8   ASP ASP B . n 
B 1 11  GLU 11  9   9   GLU GLU B . n 
B 1 12  PRO 12  10  10  PRO PRO B . n 
B 1 13  ASN 13  11  11  ASN ASN B . n 
B 1 14  ALA 14  12  12  ALA ALA B . n 
B 1 15  LEU 15  13  13  LEU LEU B . n 
B 1 16  LEU 16  14  14  LEU LEU B . n 
B 1 17  SER 17  15  15  SER SER B . n 
B 1 18  TYR 18  16  16  TYR TYR B . n 
B 1 19  ASP 19  17  17  ASP ASP B . n 
B 1 20  PHE 20  18  18  PHE PHE B . n 
B 1 21  ASP 21  19  19  ASP ASP B . n 
B 1 22  ARG 22  20  20  ARG ARG B . n 
B 1 23  GLY 23  21  21  GLY GLY B . n 
B 1 24  SER 24  22  22  SER SER B . n 
B 1 25  ASN 25  23  23  ASN ASN B . n 
B 1 26  TYR 26  24  24  TYR TYR B . n 
B 1 27  GLU 27  25  25  GLU GLU B . n 
B 1 28  ASN 28  26  26  ASN ASN B . n 
B 1 29  VAL 29  27  27  VAL VAL B . n 
B 1 30  LEU 30  28  28  LEU LEU B . n 
B 1 31  HIS 31  29  29  HIS HIS B . n 
B 1 32  LEU 32  30  30  LEU LEU B . n 
B 1 33  THR 33  31  31  THR THR B . n 
B 1 34  ASP 34  32  32  ASP ASP B . n 
B 1 35  ALA 35  33  33  ALA ALA B . n 
B 1 36  LEU 36  34  34  LEU LEU B . n 
B 1 37  GLY 37  35  35  GLY GLY B . n 
B 1 38  ALA 38  36  36  ALA ALA B . n 
B 1 39  LEU 39  37  37  LEU LEU B . n 
B 1 40  VAL 40  38  38  VAL VAL B . n 
B 1 41  PRO 41  39  39  PRO PRO B . n 
B 1 42  GLU 42  40  40  GLU GLU B . n 
B 1 43  SER 43  41  41  SER SER B . n 
B 1 44  GLU 44  42  42  GLU GLU B . n 
B 1 45  THR 45  43  43  THR THR B . n 
B 1 46  GLU 46  44  44  GLU GLU B . n 
B 1 47  HIS 47  45  45  HIS HIS B . n 
B 1 48  PRO 48  46  46  PRO PRO B . n 
B 1 49  ASP 49  47  47  ASP ASP B . n 
B 1 50  GLN 50  48  48  GLN GLN B . n 
B 1 51  ARG 51  49  49  ARG ARG B . n 
B 1 52  PHE 52  50  50  PHE PHE B . n 
B 1 53  PHE 53  51  51  PHE PHE B . n 
B 1 54  GLN 54  52  52  GLN GLN B . n 
B 1 55  VAL 55  53  53  VAL VAL B . n 
B 1 56  THR 56  54  54  THR THR B . n 
B 1 57  HIS 57  55  55  HIS HIS B . n 
B 1 58  LEU 58  56  56  LEU LEU B . n 
B 1 59  ILE 59  57  57  ILE ILE B . n 
B 1 60  THR 60  58  58  THR THR B . n 
B 1 61  GLU 61  59  59  GLU GLU B . n 
B 1 62  TYR 62  60  60  TYR TYR B . n 
B 1 63  ALA 63  61  61  ALA ALA B . n 
B 1 64  TRP 64  62  62  TRP TRP B . n 
B 1 65  VAL 65  63  63  VAL VAL B . n 
B 1 66  GLN 66  64  64  GLN GLN B . n 
B 1 67  VAL 67  65  65  VAL VAL B . n 
B 1 68  HIS 68  66  66  HIS HIS B . n 
B 1 69  TYR 69  67  67  TYR TYR B . n 
B 1 70  GLU 70  68  68  GLU GLU B . n 
B 1 71  LEU 71  69  69  LEU LEU B . n 
B 1 72  ARG 72  70  70  ARG ARG B . n 
B 1 73  ARG 73  71  71  ARG ARG B . n 
B 1 74  ALA 74  72  72  ALA ALA B . n 
B 1 75  ILE 75  73  73  ILE ILE B . n 
B 1 76  GLY 76  74  74  GLY GLY B . n 
B 1 77  HIS 77  75  75  HIS HIS B . n 
B 1 78  LEU 78  76  76  LEU LEU B . n 
B 1 79  ASP 79  77  77  ASP ASP B . n 
B 1 80  GLU 80  78  78  GLU GLU B . n 
B 1 81  ASP 81  79  79  ASP ASP B . n 
B 1 82  ARG 82  80  80  ARG ARG B . n 
B 1 83  TYR 83  81  81  TYR TYR B . n 
B 1 84  HIS 84  82  82  HIS HIS B . n 
B 1 85  GLN 85  83  83  GLN GLN B . n 
B 1 86  ALA 86  84  84  ALA ALA B . n 
B 1 87  VAL 87  85  85  VAL VAL B . n 
B 1 88  ARG 88  86  86  ARG ARG B . n 
B 1 89  MET 89  87  87  MET MET B . n 
B 1 90  PHE 90  88  88  PHE PHE B . n 
B 1 91  ASP 91  89  89  ASP ASP B . n 
B 1 92  ARG 92  90  90  ARG ARG B . n 
B 1 93  ALA 93  91  91  ALA ALA B . n 
B 1 94  THR 94  92  92  THR THR B . n 
B 1 95  GLY 95  93  93  GLY GLY B . n 
B 1 96  LEU 96  94  94  LEU LEU B . n 
B 1 97  SER 97  95  95  SER SER B . n 
B 1 98  GLU 98  96  96  GLU GLU B . n 
B 1 99  VAL 99  97  97  VAL VAL B . n 
B 1 100 THR 100 98  98  THR THR B . n 
B 1 101 VAL 101 99  99  VAL VAL B . n 
B 1 102 GLN 102 100 100 GLN GLN B . n 
B 1 103 ALA 103 101 101 ALA ALA B . n 
B 1 104 VAL 104 102 102 VAL VAL B . n 
B 1 105 ARG 105 103 103 ARG ARG B . n 
B 1 106 LEU 106 104 104 LEU LEU B . n 
B 1 107 LEU 107 105 105 LEU LEU B . n 
B 1 108 THR 108 106 106 THR THR B . n 
B 1 109 ASP 109 107 107 ASP ASP B . n 
B 1 110 HIS 110 108 108 HIS HIS B . n 
B 1 111 LEU 111 109 109 LEU LEU B . n 
B 1 112 PRO 112 110 110 PRO PRO B . n 
B 1 113 GLN 113 111 111 GLN GLN B . n 
B 1 114 HIS 114 112 112 HIS HIS B . n 
B 1 115 SER 115 113 113 SER SER B . n 
B 1 116 LEU 116 114 114 LEU LEU B . n 
B 1 117 LEU 117 115 115 LEU LEU B . n 
B 1 118 MET 118 116 116 MET MET B . n 
B 1 119 MET 119 117 117 MET MET B . n 
B 1 120 ARG 120 118 118 ARG ARG B . n 
B 1 121 ASN 121 119 119 ASN ASN B . n 
B 1 122 ALA 122 120 120 ALA ALA B . n 
B 1 123 LEU 123 121 121 LEU LEU B . n 
B 1 124 PRO 124 122 122 PRO PRO B . n 
B 1 125 GLU 125 123 123 GLU GLU B . n 
B 1 126 ASP 126 124 124 ASP ASP B . n 
B 1 127 ALA 127 125 125 ALA ALA B . n 
B 1 128 THR 128 126 126 THR THR B . n 
B 1 129 GLY 129 127 127 GLY GLY B . n 
B 1 130 LEU 130 128 128 LEU LEU B . n 
B 1 131 ASP 131 129 129 ASP ASP B . n 
B 1 132 SER 132 130 130 SER SER B . n 
B 1 133 PRO 133 131 131 PRO PRO B . n 
B 1 134 GLY 134 132 132 GLY GLY B . n 
B 1 135 TYR 135 133 133 TYR TYR B . n 
B 1 136 ARG 136 134 134 ARG ARG B . n 
B 1 137 ASN 137 135 135 ASN ASN B . n 
B 1 138 LEU 138 136 136 LEU LEU B . n 
B 1 139 ARG 139 137 137 ARG ARG B . n 
B 1 140 ARG 140 138 138 ARG ARG B . n 
B 1 141 VAL 141 139 139 VAL VAL B . n 
B 1 142 ALA 142 140 140 ALA ALA B . n 
B 1 143 ARG 143 141 141 ARG ARG B . n 
B 1 144 PRO 144 142 142 PRO PRO B . n 
B 1 145 VAL 145 143 143 VAL VAL B . n 
B 1 146 TRP 146 144 144 TRP TRP B . n 
B 1 147 LYS 147 145 145 LYS LYS B . n 
B 1 148 ALA 148 146 146 ALA ALA B . n 
B 1 149 TYR 149 147 147 TYR TYR B . n 
B 1 150 GLU 150 148 148 GLU GLU B . n 
B 1 151 GLN 151 149 149 GLN GLN B . n 
B 1 152 ALA 152 150 150 ALA ALA B . n 
B 1 153 VAL 153 151 151 VAL VAL B . n 
B 1 154 GLU 154 152 152 GLU GLU B . n 
B 1 155 ARG 155 153 153 ARG ARG B . n 
B 1 156 ALA 156 154 154 ALA ALA B . n 
B 1 157 GLY 157 155 155 GLY GLY B . n 
B 1 158 LEU 158 156 156 LEU LEU B . n 
B 1 159 SER 159 157 157 SER SER B . n 
B 1 160 LEU 160 158 158 LEU LEU B . n 
B 1 161 GLN 161 159 159 GLN GLN B . n 
B 1 162 ASP 162 160 160 ASP ASP B . n 
B 1 163 VAL 163 161 161 VAL VAL B . n 
B 1 164 ILE 164 162 162 ILE ILE B . n 
B 1 165 ALA 165 163 163 ALA ALA B . n 
B 1 166 GLN 166 164 164 GLN GLN B . n 
B 1 167 GLN 167 165 165 GLN GLN B . n 
B 1 168 ASP 168 166 166 ASP ASP B . n 
B 1 169 ASP 169 167 167 ASP ASP B . n 
B 1 170 GLY 170 168 168 GLY GLY B . n 
B 1 171 TYR 171 169 169 TYR TYR B . n 
B 1 172 ASP 172 170 170 ASP ASP B . n 
B 1 173 GLY 173 171 171 GLY GLY B . n 
B 1 174 PRO 174 172 172 PRO PRO B . n 
B 1 175 ARG 175 173 173 ARG ARG B . n 
B 1 176 SER 176 174 174 SER SER B . n 
B 1 177 GLY 177 175 175 GLY GLY B . n 
B 1 178 GLY 178 176 176 GLY GLY B . n 
B 1 179 SER 179 177 177 SER SER B . n 
B 1 180 GLN 180 178 178 GLN GLN B . n 
B 1 181 SER 181 179 179 SER SER B . n 
B 1 182 LEU 182 180 180 LEU LEU B . n 
B 1 183 ALA 183 181 181 ALA ALA B . n 
B 1 184 LEU 184 182 182 LEU LEU B . n 
B 1 185 VAL 185 183 183 VAL VAL B . n 
B 1 186 ARG 186 184 184 ARG ARG B . n 
B 1 187 GLU 187 185 185 GLU GLU B . n 
B 1 188 ALA 188 186 186 ALA ALA B . n 
B 1 189 MET 189 187 187 MET MET B . n 
B 1 190 LEU 190 188 188 LEU LEU B . n 
B 1 191 ARG 191 189 189 ARG ARG B . n 
B 1 192 LEU 192 190 190 LEU LEU B . n 
B 1 193 ASP 193 191 191 ASP ASP B . n 
B 1 194 GLY 194 192 192 GLY GLY B . n 
B 1 195 SER 195 193 193 SER SER B . n 
B 1 196 VAL 196 194 194 VAL VAL B . n 
B 1 197 LEU 197 195 195 LEU LEU B . n 
B 1 198 GLY 198 196 196 GLY GLY B . n 
B 1 199 TRP 199 197 197 TRP TRP B . n 
B 1 200 LYS 200 198 198 LYS LYS B . n 
B 1 201 GLN 201 199 199 GLN GLN B . n 
B 1 202 HIS 202 200 200 HIS HIS B . n 
B 1 203 HIS 203 201 201 HIS HIS B . n 
B 1 204 LEU 204 202 202 LEU LEU B . n 
B 1 205 ILE 205 203 203 ILE ILE B . n 
B 1 206 MET 206 204 204 MET MET B . n 
B 1 207 VAL 207 205 205 VAL VAL B . n 
B 1 208 TRP 208 206 206 TRP TRP B . n 
B 1 209 SER 209 207 207 SER SER B . n 
B 1 210 GLN 210 208 208 GLN GLN B . n 
B 1 211 LEU 211 209 209 LEU LEU B . n 
B 1 212 GLY 212 210 210 GLY GLY B . n 
B 1 213 GLY 213 211 211 GLY GLY B . n 
B 1 214 GLN 214 212 212 GLN GLN B . n 
B 1 215 PRO 215 213 213 PRO PRO B . n 
B 1 216 GLY 216 214 214 GLY GLY B . n 
B 1 217 LEU 217 215 215 LEU LEU B . n 
B 1 218 ARG 218 216 216 ARG ARG B . n 
B 1 219 LYS 219 217 ?   ?   ?   B . n 
B 1 220 GLY 220 218 ?   ?   ?   B . n 
B 1 221 ASN 221 219 ?   ?   ?   B . n 
B 1 222 GLU 222 220 ?   ?   ?   B . n 
B 1 223 GLU 223 221 ?   ?   ?   B . n 
B 1 224 GLY 224 222 ?   ?   ?   B . n 
B 1 225 ASP 225 223 ?   ?   ?   B . n 
B 1 226 ASP 226 224 ?   ?   ?   B . n 
B 1 227 GLY 227 225 ?   ?   ?   B . n 
B 1 228 LEU 228 226 ?   ?   ?   B . n 
B 1 229 GLU 229 227 ?   ?   ?   B . n 
B 1 230 LEU 230 228 ?   ?   ?   B . n 
B 1 231 PRO 231 229 ?   ?   ?   B . n 
B 1 232 GLN 232 230 ?   ?   ?   B . n 
B 1 233 SER 233 231 ?   ?   ?   B . n 
B 1 234 LEU 234 232 ?   ?   ?   B . n 
B 1 235 GLY 235 233 ?   ?   ?   B . n 
B 1 236 GLY 236 234 ?   ?   ?   B . n 
B 1 237 ARG 237 235 235 ARG ARG B . n 
B 1 238 SER 238 236 236 SER SER B . n 
B 1 239 LEU 239 237 237 LEU LEU B . n 
B 1 240 ALA 240 238 238 ALA ALA B . n 
B 1 241 THR 241 239 239 THR THR B . n 
B 1 242 LEU 242 240 240 LEU LEU B . n 
B 1 243 GLU 243 241 241 GLU GLU B . n 
B 1 244 ALA 244 242 242 ALA ALA B . n 
B 1 245 ARG 245 243 243 ARG ARG B . n 
B 1 246 SER 246 244 244 SER SER B . n 
B 1 247 GLN 247 245 245 GLN GLN B . n 
B 1 248 LEU 248 246 246 LEU LEU B . n 
B 1 249 ALA 249 247 247 ALA ALA B . n 
B 1 250 LEU 250 248 248 LEU LEU B . n 
B 1 251 PHE 251 249 249 PHE PHE B . n 
B 1 252 PRO 252 250 250 PRO PRO B . n 
B 1 253 GLU 253 251 251 GLU GLU B . n 
B 1 254 LEU 254 252 252 LEU LEU B . n 
B 1 255 TRP 255 253 253 TRP TRP B . n 
B 1 256 ARG 256 254 254 ARG ARG B . n 
B 1 257 ALA 257 255 255 ALA ALA B . n 
B 1 258 ALA 258 256 256 ALA ALA B . n 
B 1 259 GLU 259 257 257 GLU GLU B . n 
B 1 260 ASP 260 258 258 ASP ASP B . n 
B 1 261 ALA 261 259 259 ALA ALA B . n 
B 1 262 TYR 262 260 260 TYR TYR B . n 
B 1 263 TRP 263 261 261 TRP TRP B . n 
B 1 264 LEU 264 262 262 LEU LEU B . n 
B 1 265 LEU 265 263 263 LEU LEU B . n 
B 1 266 GLY 266 264 264 GLY GLY B . n 
B 1 267 THR 267 265 265 THR THR B . n 
B 1 268 ARG 268 266 ?   ?   ?   B . n 
B 1 269 HIS 269 267 ?   ?   ?   B . n 
B 1 270 ASP 270 268 ?   ?   ?   B . n 
B 1 271 THR 271 269 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 78U ? ? 78U ? ? 'SUBJECT OF INVESTIGATION' ? 
2 HEM ? ? HEM ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 HEM 1  301 301 HEM HEM A . 
D 3 78U 1  302 401 78U 78U A . 
E 2 HEM 1  301 301 HEM HEM B . 
F 3 78U 1  302 401 78U 78U B . 
G 4 HOH 1  401 75  HOH HOH A . 
G 4 HOH 2  402 34  HOH HOH A . 
G 4 HOH 3  403 42  HOH HOH A . 
G 4 HOH 4  404 61  HOH HOH A . 
G 4 HOH 5  405 67  HOH HOH A . 
G 4 HOH 6  406 26  HOH HOH A . 
G 4 HOH 7  407 78  HOH HOH A . 
G 4 HOH 8  408 23  HOH HOH A . 
G 4 HOH 9  409 25  HOH HOH A . 
G 4 HOH 10 410 7   HOH HOH A . 
G 4 HOH 11 411 16  HOH HOH A . 
G 4 HOH 12 412 8   HOH HOH A . 
G 4 HOH 13 413 13  HOH HOH A . 
G 4 HOH 14 414 82  HOH HOH A . 
G 4 HOH 15 415 37  HOH HOH A . 
G 4 HOH 16 416 14  HOH HOH A . 
G 4 HOH 17 417 60  HOH HOH A . 
G 4 HOH 18 418 79  HOH HOH A . 
G 4 HOH 19 419 74  HOH HOH A . 
G 4 HOH 20 420 2   HOH HOH A . 
G 4 HOH 21 421 31  HOH HOH A . 
G 4 HOH 22 422 3   HOH HOH A . 
G 4 HOH 23 423 28  HOH HOH A . 
G 4 HOH 24 424 71  HOH HOH A . 
G 4 HOH 25 425 38  HOH HOH A . 
G 4 HOH 26 426 54  HOH HOH A . 
G 4 HOH 27 427 86  HOH HOH A . 
G 4 HOH 28 428 73  HOH HOH A . 
G 4 HOH 29 429 49  HOH HOH A . 
G 4 HOH 30 430 24  HOH HOH A . 
G 4 HOH 31 431 35  HOH HOH A . 
G 4 HOH 32 432 48  HOH HOH A . 
G 4 HOH 33 433 97  HOH HOH A . 
G 4 HOH 34 434 77  HOH HOH A . 
G 4 HOH 35 435 80  HOH HOH A . 
G 4 HOH 36 436 18  HOH HOH A . 
G 4 HOH 37 437 32  HOH HOH A . 
G 4 HOH 38 438 72  HOH HOH A . 
G 4 HOH 39 439 91  HOH HOH A . 
G 4 HOH 40 440 92  HOH HOH A . 
G 4 HOH 41 441 94  HOH HOH A . 
G 4 HOH 42 442 89  HOH HOH A . 
G 4 HOH 43 443 93  HOH HOH A . 
G 4 HOH 44 444 76  HOH HOH A . 
G 4 HOH 45 445 90  HOH HOH A . 
G 4 HOH 46 446 84  HOH HOH A . 
G 4 HOH 47 447 81  HOH HOH A . 
H 4 HOH 1  401 56  HOH HOH B . 
H 4 HOH 2  402 36  HOH HOH B . 
H 4 HOH 3  403 27  HOH HOH B . 
H 4 HOH 4  404 88  HOH HOH B . 
H 4 HOH 5  405 4   HOH HOH B . 
H 4 HOH 6  406 17  HOH HOH B . 
H 4 HOH 7  407 5   HOH HOH B . 
H 4 HOH 8  408 11  HOH HOH B . 
H 4 HOH 9  409 12  HOH HOH B . 
H 4 HOH 10 410 50  HOH HOH B . 
H 4 HOH 11 411 65  HOH HOH B . 
H 4 HOH 12 412 39  HOH HOH B . 
H 4 HOH 13 413 29  HOH HOH B . 
H 4 HOH 14 414 51  HOH HOH B . 
H 4 HOH 15 415 66  HOH HOH B . 
H 4 HOH 16 416 20  HOH HOH B . 
H 4 HOH 17 417 1   HOH HOH B . 
H 4 HOH 18 418 45  HOH HOH B . 
H 4 HOH 19 419 15  HOH HOH B . 
H 4 HOH 20 420 52  HOH HOH B . 
H 4 HOH 21 421 6   HOH HOH B . 
H 4 HOH 22 422 41  HOH HOH B . 
H 4 HOH 23 423 19  HOH HOH B . 
H 4 HOH 24 424 63  HOH HOH B . 
H 4 HOH 25 425 64  HOH HOH B . 
H 4 HOH 26 426 68  HOH HOH B . 
H 4 HOH 27 427 59  HOH HOH B . 
H 4 HOH 28 428 43  HOH HOH B . 
H 4 HOH 29 429 55  HOH HOH B . 
H 4 HOH 30 430 47  HOH HOH B . 
H 4 HOH 31 431 62  HOH HOH B . 
H 4 HOH 32 432 10  HOH HOH B . 
H 4 HOH 33 433 40  HOH HOH B . 
H 4 HOH 34 434 30  HOH HOH B . 
H 4 HOH 35 435 21  HOH HOH B . 
H 4 HOH 36 436 83  HOH HOH B . 
H 4 HOH 37 437 44  HOH HOH B . 
H 4 HOH 38 438 58  HOH HOH B . 
H 4 HOH 39 439 85  HOH HOH B . 
H 4 HOH 40 440 57  HOH HOH B . 
H 4 HOH 41 441 22  HOH HOH B . 
H 4 HOH 42 442 33  HOH HOH B . 
H 4 HOH 43 443 98  HOH HOH B . 
H 4 HOH 44 444 69  HOH HOH B . 
H 4 HOH 45 445 95  HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8VYY 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     196.119 
_cell.length_a_esd                 ? 
_cell.length_b                     196.119 
_cell.length_b_esd                 ? 
_cell.length_c                     113.060 
_cell.length_c_esd                 ? 
_cell.volume                       4348588.584 
_cell.volume_esd                   ? 
_cell.Z_PDB                        32 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8VYY 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                97 
_symmetry.space_group_name_Hall            'I 4 2' 
_symmetry.space_group_name_H-M             'I 4 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8VYY 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             4.44 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          72.31 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Ethylene glycol (25% v/v)' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-06-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97946 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL9-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97946 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL9-2 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          52.27 
_reflns.entry_id                                       8VYY 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.45 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40492 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                25.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          3.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.731 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.174 
_reflns.pdbx_Rpim_I_all                                0.034 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       1010353 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1.000 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.170 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.45 2.49  ? ? ? ? ? ? 1985 ? ? ? ? ? ? ? ? ? ? ? 13.4 0.700 ? ? 2.440 0.643 ? 1  1 0.385 0.746 ? 99.9  ? 2.348 ? ? ? ? ? ? ? ? ? 
2.49 2.54  ? ? ? ? ? ? 2009 ? ? ? ? ? ? ? ? ? ? ? 17.5 0.699 ? ? 2.198 0.516 ? 2  1 0.565 0.850 ? 100.0 ? 2.135 ? ? ? ? ? ? ? ? ? 
2.54 2.59  ? ? ? ? ? ? 1975 ? ? ? ? ? ? ? ? ? ? ? 21.0 0.698 ? ? 1.901 0.410 ? 3  1 0.720 0.915 ? 100.0 ? 1.855 ? ? ? ? ? ? ? ? ? 
2.59 2.64  ? ? ? ? ? ? 2002 ? ? ? ? ? ? ? ? ? ? ? 23.9 0.709 ? ? 1.649 0.335 ? 4  1 0.815 0.948 ? 100.0 ? 1.614 ? ? ? ? ? ? ? ? ? 
2.64 2.70  ? ? ? ? ? ? 1996 ? ? ? ? ? ? ? ? ? ? ? 25.8 0.718 ? ? 1.321 0.259 ? 5  1 0.869 0.964 ? 100.0 ? 1.295 ? ? ? ? ? ? ? ? ? 
2.70 2.76  ? ? ? ? ? ? 2039 ? ? ? ? ? ? ? ? ? ? ? 26.0 0.714 ? ? 1.157 0.226 ? 6  1 0.892 0.971 ? 100.0 ? 1.135 ? ? ? ? ? ? ? ? ? 
2.76 2.83  ? ? ? ? ? ? 1982 ? ? ? ? ? ? ? ? ? ? ? 24.0 0.720 ? ? 0.926 0.187 ? 7  1 0.934 0.983 ? 100.0 ? 0.907 ? ? ? ? ? ? ? ? ? 
2.83 2.90  ? ? ? ? ? ? 1981 ? ? ? ? ? ? ? ? ? ? ? 27.7 0.724 ? ? 0.817 0.155 ? 8  1 0.960 0.990 ? 100.0 ? 0.802 ? ? ? ? ? ? ? ? ? 
2.90 2.99  ? ? ? ? ? ? 2019 ? ? ? ? ? ? ? ? ? ? ? 27.8 0.735 ? ? 0.648 0.122 ? 9  1 0.968 0.992 ? 100.0 ? 0.636 ? ? ? ? ? ? ? ? ? 
2.99 3.09  ? ? ? ? ? ? 2010 ? ? ? ? ? ? ? ? ? ? ? 27.6 0.748 ? ? 0.541 0.103 ? 10 1 0.978 0.994 ? 100.0 ? 0.531 ? ? ? ? ? ? ? ? ? 
3.09 3.20  ? ? ? ? ? ? 1998 ? ? ? ? ? ? ? ? ? ? ? 27.2 0.748 ? ? 0.465 0.089 ? 11 1 0.982 0.996 ? 99.9  ? 0.456 ? ? ? ? ? ? ? ? ? 
3.20 3.32  ? ? ? ? ? ? 2049 ? ? ? ? ? ? ? ? ? ? ? 26.5 0.765 ? ? 0.334 0.065 ? 12 1 0.990 0.997 ? 100.0 ? 0.327 ? ? ? ? ? ? ? ? ? 
3.32 3.48  ? ? ? ? ? ? 1991 ? ? ? ? ? ? ? ? ? ? ? 24.5 0.789 ? ? 0.236 0.047 ? 13 1 0.993 0.998 ? 100.0 ? 0.231 ? ? ? ? ? ? ? ? ? 
3.48 3.66  ? ? ? ? ? ? 2024 ? ? ? ? ? ? ? ? ? ? ? 27.4 0.811 ? ? 0.198 0.038 ? 14 1 0.996 0.999 ? 100.0 ? 0.195 ? ? ? ? ? ? ? ? ? 
3.66 3.89  ? ? ? ? ? ? 2022 ? ? ? ? ? ? ? ? ? ? ? 27.5 0.855 ? ? 0.144 0.027 ? 15 1 0.998 0.999 ? 100.0 ? 0.141 ? ? ? ? ? ? ? ? ? 
3.89 4.19  ? ? ? ? ? ? 2057 ? ? ? ? ? ? ? ? ? ? ? 27.1 0.804 ? ? 0.107 0.020 ? 16 1 0.999 1.000 ? 100.0 ? 0.105 ? ? ? ? ? ? ? ? ? 
4.19 4.61  ? ? ? ? ? ? 2028 ? ? ? ? ? ? ? ? ? ? ? 25.0 0.774 ? ? 0.086 0.017 ? 17 1 0.999 1.000 ? 100.0 ? 0.084 ? ? ? ? ? ? ? ? ? 
4.61 5.28  ? ? ? ? ? ? 2046 ? ? ? ? ? ? ? ? ? ? ? 27.7 0.728 ? ? 0.080 0.015 ? 18 1 0.999 1.000 ? 100.0 ? 0.079 ? ? ? ? ? ? ? ? ? 
5.28 6.65  ? ? ? ? ? ? 2089 ? ? ? ? ? ? ? ? ? ? ? 25.9 0.662 ? ? 0.081 0.016 ? 19 1 0.999 1.000 ? 100.0 ? 0.079 ? ? ? ? ? ? ? ? ? 
6.65 50.00 ? ? ? ? ? ? 2190 ? ? ? ? ? ? ? ? ? ? ? 25.1 0.478 ? ? 0.037 0.007 ? 20 1 1.000 1.000 ? 100.0 ? 0.036 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               56.61 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8VYY 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.45 
_refine.ls_d_res_low                             43.85 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39790 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  37790 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.17 
_refine.ls_percent_reflns_R_free                 5.03 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1783 
_refine.ls_R_factor_R_free                       0.2095 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1766 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.7967 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3159 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.45 
_refine_hist.d_res_low                        43.85 
_refine_hist.number_atoms_solvent             92 
_refine_hist.number_atoms_total               4112 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3902 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         118 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0085 ? 4187 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1482 ? 5727 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0444 ? 597  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0102 ? 745  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 9.3746 ? 573  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.45 2.51  . . 134 2536 93.62 . . . . 0.3330 . . . . . . . . . . . 0.3432 
'X-RAY DIFFRACTION' 2.51 2.58  . . 138 2623 96.14 . . . . 0.2708 . . . . . . . . . . . 0.3371 
'X-RAY DIFFRACTION' 2.58 2.66  . . 138 2588 96.70 . . . . 0.2250 . . . . . . . . . . . 0.2525 
'X-RAY DIFFRACTION' 2.66 2.74  . . 141 2663 97.77 . . . . 0.2033 . . . . . . . . . . . 0.2425 
'X-RAY DIFFRACTION' 2.74 2.84  . . 141 2664 97.46 . . . . 0.2022 . . . . . . . . . . . 0.2243 
'X-RAY DIFFRACTION' 2.84 2.95  . . 140 2648 98.10 . . . . 0.1994 . . . . . . . . . . . 0.2537 
'X-RAY DIFFRACTION' 2.95 3.09  . . 143 2710 98.72 . . . . 0.2110 . . . . . . . . . . . 0.2324 
'X-RAY DIFFRACTION' 3.09 3.25  . . 142 2685 98.60 . . . . 0.2003 . . . . . . . . . . . 0.2409 
'X-RAY DIFFRACTION' 3.25 3.45  . . 143 2703 99.27 . . . . 0.1797 . . . . . . . . . . . 0.2320 
'X-RAY DIFFRACTION' 3.45 3.72  . . 145 2742 99.55 . . . . 0.1717 . . . . . . . . . . . 0.2213 
'X-RAY DIFFRACTION' 3.72 4.10  . . 146 2753 99.79 . . . . 0.1612 . . . . . . . . . . . 0.2115 
'X-RAY DIFFRACTION' 4.10 4.69  . . 147 2762 99.62 . . . . 0.1361 . . . . . . . . . . . 0.1814 
'X-RAY DIFFRACTION' 4.69 5.90  . . 148 2801 99.83 . . . . 0.1649 . . . . . . . . . . . 0.1791 
'X-RAY DIFFRACTION' 5.90 43.85 . . 154 2912 99.16 . . . . 0.1601 . . . . . . . . . . . 0.1651 
# 
_struct.entry_id                     8VYY 
_struct.title                        'The crystal structure of MarE in complex with its native substrate, beta-methyl-L-tryptophan' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8VYY 
_struct_keywords.text            'Oxygenase, Monooxygenase, Heme-dependent aromatic oxygenase (HDAO), OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    X2D878_9ACTN 
_struct_ref.pdbx_db_accession          X2D878 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKRSLNPDEPNALLSYDFDRGSNYENVLHLTDALGALVPESETEHPDQRFFQVTHLITEYAWVQVHYELRRAIGHLDEDR
YHQAVRMFDRATGLSEVTVQAVRLLTDHLPQHSLLMMRNALPEDATGLDSPGYRNLRRVARPVWKAYEQAVERAGLSLQD
VIAQQDDGYDGPRSGGSQSLALVREAMLRLDGSVLGWKQHHLIMVWSQLGGQPGLRKGNEEGDDGLELPQSLGGRSLATL
EARSQLALFPELWRAAEDAYWLLGTRHDT
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8VYY A 3 ? 271 ? X2D878 1 ? 269 ? 1 269 
2 1 8VYY B 3 ? 271 ? X2D878 1 ? 269 ? 1 269 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8VYY GLY A 1 ? UNP X2D878 ? ? 'expression tag' -1 1 
1 8VYY HIS A 2 ? UNP X2D878 ? ? 'expression tag' 0  2 
2 8VYY GLY B 1 ? UNP X2D878 ? ? 'expression tag' -1 3 
2 8VYY HIS B 2 ? UNP X2D878 ? ? 'expression tag' 0  4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 30570 ? 
1 MORE         -212  ? 
1 'SSA (A^2)'  31260 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z      1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000    
2 'crystal symmetry operation' 8_554 -y,-x,-z-1 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -113.0600000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 24  ? HIS A 31  ? SER A 22  HIS A 29  1 ? 8  
HELX_P HELX_P2  AA2 HIS A 31  ? ALA A 38  ? HIS A 29  ALA A 36  1 ? 8  
HELX_P HELX_P3  AA3 PRO A 41  ? THR A 45  ? PRO A 39  THR A 43  5 ? 5  
HELX_P HELX_P4  AA4 ASP A 49  ? GLU A 80  ? ASP A 47  GLU A 78  1 ? 32 
HELX_P HELX_P5  AA5 ARG A 82  ? LEU A 111 ? ARG A 80  LEU A 109 1 ? 30 
HELX_P HELX_P6  AA6 PRO A 112 ? LEU A 123 ? PRO A 110 LEU A 121 1 ? 12 
HELX_P HELX_P7  AA7 THR A 128 ? ASP A 131 ? THR A 126 ASP A 129 5 ? 4  
HELX_P HELX_P8  AA8 SER A 132 ? ALA A 156 ? SER A 130 ALA A 154 1 ? 25 
HELX_P HELX_P9  AA9 SER A 159 ? GLN A 166 ? SER A 157 GLN A 164 1 ? 8  
HELX_P HELX_P10 AB1 SER A 176 ? GLY A 212 ? SER A 174 GLY A 210 1 ? 37 
HELX_P HELX_P11 AB2 GLN A 214 ? ARG A 218 ? GLN A 212 ARG A 216 5 ? 5  
HELX_P HELX_P12 AB3 SER A 238 ? SER A 246 ? SER A 236 SER A 244 1 ? 9  
HELX_P HELX_P13 AB4 PHE A 251 ? GLY A 266 ? PHE A 249 GLY A 264 1 ? 16 
HELX_P HELX_P14 AB5 SER B 24  ? HIS B 31  ? SER B 22  HIS B 29  1 ? 8  
HELX_P HELX_P15 AB6 HIS B 31  ? ALA B 38  ? HIS B 29  ALA B 36  1 ? 8  
HELX_P HELX_P16 AB7 ASP B 49  ? GLU B 80  ? ASP B 47  GLU B 78  1 ? 32 
HELX_P HELX_P17 AB8 ARG B 82  ? LEU B 111 ? ARG B 80  LEU B 109 1 ? 30 
HELX_P HELX_P18 AB9 PRO B 112 ? ASN B 121 ? PRO B 110 ASN B 119 1 ? 10 
HELX_P HELX_P19 AC1 THR B 128 ? ASP B 131 ? THR B 126 ASP B 129 5 ? 4  
HELX_P HELX_P20 AC2 SER B 132 ? ALA B 156 ? SER B 130 ALA B 154 1 ? 25 
HELX_P HELX_P21 AC3 SER B 159 ? GLN B 166 ? SER B 157 GLN B 164 1 ? 8  
HELX_P HELX_P22 AC4 SER B 176 ? GLY B 212 ? SER B 174 GLY B 210 1 ? 37 
HELX_P HELX_P23 AC5 GLN B 214 ? ARG B 218 ? GLN B 212 ARG B 216 5 ? 5  
HELX_P HELX_P24 AC6 SER B 238 ? SER B 246 ? SER B 236 SER B 244 1 ? 9  
HELX_P HELX_P25 AC7 PHE B 251 ? GLY B 266 ? PHE B 249 GLY B 264 1 ? 16 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A HIS 203 NE2 ? ? ? 1_555 C HEM . FE ? ? A HIS 201 A HEM 301 1_555 ? ? ? ? ? ? ? 2.100 ? ? 
metalc2 metalc ? ? B HIS 203 NE2 ? ? ? 1_555 E HEM . FE ? ? B HIS 201 B HEM 301 1_555 ? ? ? ? ? ? ? 2.119 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 203 ? A HIS 201 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 NA ? C HEM . ? A HEM 301 ? 1_555 97.5  ? 
2  NE2 ? A HIS 203 ? A HIS 201 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 NB ? C HEM . ? A HEM 301 ? 1_555 100.7 ? 
3  NA  ? C HEM .   ? A HEM 301 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 NB ? C HEM . ? A HEM 301 ? 1_555 87.0  ? 
4  NE2 ? A HIS 203 ? A HIS 201 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 NC ? C HEM . ? A HEM 301 ? 1_555 99.7  ? 
5  NA  ? C HEM .   ? A HEM 301 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 NC ? C HEM . ? A HEM 301 ? 1_555 162.7 ? 
6  NB  ? C HEM .   ? A HEM 301 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 NC ? C HEM . ? A HEM 301 ? 1_555 88.1  ? 
7  NE2 ? A HIS 203 ? A HIS 201 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 ND ? C HEM . ? A HEM 301 ? 1_555 95.2  ? 
8  NA  ? C HEM .   ? A HEM 301 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 ND ? C HEM . ? A HEM 301 ? 1_555 87.3  ? 
9  NB  ? C HEM .   ? A HEM 301 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 ND ? C HEM . ? A HEM 301 ? 1_555 163.8 ? 
10 NC  ? C HEM .   ? A HEM 301 ? 1_555 FE ? C HEM . ? A HEM 301 ? 1_555 ND ? C HEM . ? A HEM 301 ? 1_555 92.8  ? 
11 NE2 ? B HIS 203 ? B HIS 201 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 NA ? E HEM . ? B HEM 301 ? 1_555 96.1  ? 
12 NE2 ? B HIS 203 ? B HIS 201 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 NB ? E HEM . ? B HEM 301 ? 1_555 98.2  ? 
13 NA  ? E HEM .   ? B HEM 301 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 NB ? E HEM . ? B HEM 301 ? 1_555 88.8  ? 
14 NE2 ? B HIS 203 ? B HIS 201 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 NC ? E HEM . ? B HEM 301 ? 1_555 101.7 ? 
15 NA  ? E HEM .   ? B HEM 301 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 NC ? E HEM . ? B HEM 301 ? 1_555 162.2 ? 
16 NB  ? E HEM .   ? B HEM 301 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 NC ? E HEM . ? B HEM 301 ? 1_555 90.1  ? 
17 NE2 ? B HIS 203 ? B HIS 201 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 ND ? E HEM . ? B HEM 301 ? 1_555 99.5  ? 
18 NA  ? E HEM .   ? B HEM 301 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 ND ? E HEM . ? B HEM 301 ? 1_555 87.0  ? 
19 NB  ? E HEM .   ? B HEM 301 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 ND ? E HEM . ? B HEM 301 ? 1_555 162.1 ? 
20 NC  ? E HEM .   ? B HEM 301 ? 1_555 FE ? E HEM . ? B HEM 301 ? 1_555 ND ? E HEM . ? B HEM 301 ? 1_555 88.7  ? 
# 
_pdbx_entry_details.entry_id                   8VYY 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OH 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   TYR 
_pdbx_validate_close_contact.auth_seq_id_1    133 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   NZ 
_pdbx_validate_close_contact.auth_asym_id_2   B 
_pdbx_validate_close_contact.auth_comp_id_2   LYS 
_pdbx_validate_close_contact.auth_seq_id_2    198 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.06 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 5   ? ? -67.60  -165.73 
2  1 ASN A 6   ? ? -167.15 115.10  
3  1 GLU A 9   ? ? -109.08 -67.55  
4  1 ALA A 12  ? ? -87.92  30.71   
5  1 LEU A 13  ? ? 71.37   -52.19  
6  1 ARG A 20  ? ? -146.56 35.07   
7  1 SER A 236 ? ? -98.02  49.33   
8  1 ASN B 6   ? ? 177.94  142.37  
9  1 ASP B 8   ? ? -126.10 -166.67 
10 1 GLU B 9   ? ? -151.99 -50.83  
11 1 ASN B 11  ? ? -176.94 -178.95 
12 1 ALA B 12  ? ? -119.93 -102.59 
13 1 ASN B 119 ? ? -67.24  2.25    
14 1 PRO B 122 ? ? -53.29  10.45   
15 1 GLU B 123 ? ? 42.88   28.25   
16 1 ASP B 124 ? ? -144.27 -10.85  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  -y,x,z               
3  y,-x,z               
4  x,-y,-z              
5  -x,y,-z              
6  -x,-y,z              
7  y,x,-z               
8  -y,-x,-z             
9  x+1/2,y+1/2,z+1/2    
10 -y+1/2,x+1/2,z+1/2   
11 y+1/2,-x+1/2,z+1/2   
12 x+1/2,-y+1/2,-z+1/2  
13 -x+1/2,y+1/2,-z+1/2  
14 -x+1/2,-y+1/2,z+1/2  
15 y+1/2,x+1/2,-z+1/2   
16 -y+1/2,-x+1/2,-z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -1  ? A GLY 1   
2  1 Y 1 A HIS 0   ? A HIS 2   
3  1 Y 1 A MET 1   ? A MET 3   
4  1 Y 1 A LYS 2   ? A LYS 4   
5  1 Y 1 A ARG 3   ? A ARG 5   
6  1 Y 1 A LYS 217 ? A LYS 219 
7  1 Y 1 A GLY 218 ? A GLY 220 
8  1 Y 1 A ASN 219 ? A ASN 221 
9  1 Y 1 A GLU 220 ? A GLU 222 
10 1 Y 1 A GLU 221 ? A GLU 223 
11 1 Y 1 A GLY 222 ? A GLY 224 
12 1 Y 1 A ASP 223 ? A ASP 225 
13 1 Y 1 A ASP 224 ? A ASP 226 
14 1 Y 1 A GLY 225 ? A GLY 227 
15 1 Y 1 A LEU 226 ? A LEU 228 
16 1 Y 1 A GLU 227 ? A GLU 229 
17 1 Y 1 A LEU 228 ? A LEU 230 
18 1 Y 1 A PRO 229 ? A PRO 231 
19 1 Y 1 A GLN 230 ? A GLN 232 
20 1 Y 1 A SER 231 ? A SER 233 
21 1 Y 1 A LEU 232 ? A LEU 234 
22 1 Y 1 A GLY 233 ? A GLY 235 
23 1 Y 1 A GLY 234 ? A GLY 236 
24 1 Y 1 A ARG 266 ? A ARG 268 
25 1 Y 1 A HIS 267 ? A HIS 269 
26 1 Y 1 A ASP 268 ? A ASP 270 
27 1 Y 1 A THR 269 ? A THR 271 
28 1 Y 1 B GLY -1  ? B GLY 1   
29 1 Y 1 B HIS 0   ? B HIS 2   
30 1 Y 1 B MET 1   ? B MET 3   
31 1 Y 1 B LYS 2   ? B LYS 4   
32 1 Y 1 B ARG 3   ? B ARG 5   
33 1 Y 1 B LYS 217 ? B LYS 219 
34 1 Y 1 B GLY 218 ? B GLY 220 
35 1 Y 1 B ASN 219 ? B ASN 221 
36 1 Y 1 B GLU 220 ? B GLU 222 
37 1 Y 1 B GLU 221 ? B GLU 223 
38 1 Y 1 B GLY 222 ? B GLY 224 
39 1 Y 1 B ASP 223 ? B ASP 225 
40 1 Y 1 B ASP 224 ? B ASP 226 
41 1 Y 1 B GLY 225 ? B GLY 227 
42 1 Y 1 B LEU 226 ? B LEU 228 
43 1 Y 1 B GLU 227 ? B GLU 229 
44 1 Y 1 B LEU 228 ? B LEU 230 
45 1 Y 1 B PRO 229 ? B PRO 231 
46 1 Y 1 B GLN 230 ? B GLN 232 
47 1 Y 1 B SER 231 ? B SER 233 
48 1 Y 1 B LEU 232 ? B LEU 234 
49 1 Y 1 B GLY 233 ? B GLY 235 
50 1 Y 1 B GLY 234 ? B GLY 236 
51 1 Y 1 B ARG 266 ? B ARG 268 
52 1 Y 1 B HIS 267 ? B HIS 269 
53 1 Y 1 B ASP 268 ? B ASP 270 
54 1 Y 1 B THR 269 ? B THR 271 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
78U OXT  O  N N 1   
78U C    C  N N 2   
78U O    O  N N 3   
78U CA   C  N S 4   
78U N    N  N N 5   
78U CB   C  N S 6   
78U CAG  C  N N 7   
78U CG   C  Y N 8   
78U CD2  C  Y N 9   
78U CE3  C  Y N 10  
78U CZ3  C  Y N 11  
78U CH2  C  Y N 12  
78U CZ2  C  Y N 13  
78U CE2  C  Y N 14  
78U NE1  N  Y N 15  
78U CD1  C  Y N 16  
78U H1   H  N N 17  
78U H2   H  N N 18  
78U H3   H  N N 19  
78U H4   H  N N 20  
78U H6   H  N N 21  
78U H7   H  N N 22  
78U H8   H  N N 23  
78U H9   H  N N 24  
78U H10  H  N N 25  
78U H11  H  N N 26  
78U H12  H  N N 27  
78U H13  H  N N 28  
78U H14  H  N N 29  
78U H15  H  N N 30  
ALA N    N  N N 31  
ALA CA   C  N S 32  
ALA C    C  N N 33  
ALA O    O  N N 34  
ALA CB   C  N N 35  
ALA OXT  O  N N 36  
ALA H    H  N N 37  
ALA H2   H  N N 38  
ALA HA   H  N N 39  
ALA HB1  H  N N 40  
ALA HB2  H  N N 41  
ALA HB3  H  N N 42  
ALA HXT  H  N N 43  
ARG N    N  N N 44  
ARG CA   C  N S 45  
ARG C    C  N N 46  
ARG O    O  N N 47  
ARG CB   C  N N 48  
ARG CG   C  N N 49  
ARG CD   C  N N 50  
ARG NE   N  N N 51  
ARG CZ   C  N N 52  
ARG NH1  N  N N 53  
ARG NH2  N  N N 54  
ARG OXT  O  N N 55  
ARG H    H  N N 56  
ARG H2   H  N N 57  
ARG HA   H  N N 58  
ARG HB2  H  N N 59  
ARG HB3  H  N N 60  
ARG HG2  H  N N 61  
ARG HG3  H  N N 62  
ARG HD2  H  N N 63  
ARG HD3  H  N N 64  
ARG HE   H  N N 65  
ARG HH11 H  N N 66  
ARG HH12 H  N N 67  
ARG HH21 H  N N 68  
ARG HH22 H  N N 69  
ARG HXT  H  N N 70  
ASN N    N  N N 71  
ASN CA   C  N S 72  
ASN C    C  N N 73  
ASN O    O  N N 74  
ASN CB   C  N N 75  
ASN CG   C  N N 76  
ASN OD1  O  N N 77  
ASN ND2  N  N N 78  
ASN OXT  O  N N 79  
ASN H    H  N N 80  
ASN H2   H  N N 81  
ASN HA   H  N N 82  
ASN HB2  H  N N 83  
ASN HB3  H  N N 84  
ASN HD21 H  N N 85  
ASN HD22 H  N N 86  
ASN HXT  H  N N 87  
ASP N    N  N N 88  
ASP CA   C  N S 89  
ASP C    C  N N 90  
ASP O    O  N N 91  
ASP CB   C  N N 92  
ASP CG   C  N N 93  
ASP OD1  O  N N 94  
ASP OD2  O  N N 95  
ASP OXT  O  N N 96  
ASP H    H  N N 97  
ASP H2   H  N N 98  
ASP HA   H  N N 99  
ASP HB2  H  N N 100 
ASP HB3  H  N N 101 
ASP HD2  H  N N 102 
ASP HXT  H  N N 103 
GLN N    N  N N 104 
GLN CA   C  N S 105 
GLN C    C  N N 106 
GLN O    O  N N 107 
GLN CB   C  N N 108 
GLN CG   C  N N 109 
GLN CD   C  N N 110 
GLN OE1  O  N N 111 
GLN NE2  N  N N 112 
GLN OXT  O  N N 113 
GLN H    H  N N 114 
GLN H2   H  N N 115 
GLN HA   H  N N 116 
GLN HB2  H  N N 117 
GLN HB3  H  N N 118 
GLN HG2  H  N N 119 
GLN HG3  H  N N 120 
GLN HE21 H  N N 121 
GLN HE22 H  N N 122 
GLN HXT  H  N N 123 
GLU N    N  N N 124 
GLU CA   C  N S 125 
GLU C    C  N N 126 
GLU O    O  N N 127 
GLU CB   C  N N 128 
GLU CG   C  N N 129 
GLU CD   C  N N 130 
GLU OE1  O  N N 131 
GLU OE2  O  N N 132 
GLU OXT  O  N N 133 
GLU H    H  N N 134 
GLU H2   H  N N 135 
GLU HA   H  N N 136 
GLU HB2  H  N N 137 
GLU HB3  H  N N 138 
GLU HG2  H  N N 139 
GLU HG3  H  N N 140 
GLU HE2  H  N N 141 
GLU HXT  H  N N 142 
GLY N    N  N N 143 
GLY CA   C  N N 144 
GLY C    C  N N 145 
GLY O    O  N N 146 
GLY OXT  O  N N 147 
GLY H    H  N N 148 
GLY H2   H  N N 149 
GLY HA2  H  N N 150 
GLY HA3  H  N N 151 
GLY HXT  H  N N 152 
HEM CHA  C  N N 153 
HEM CHB  C  N N 154 
HEM CHC  C  N N 155 
HEM CHD  C  N N 156 
HEM C1A  C  Y N 157 
HEM C2A  C  Y N 158 
HEM C3A  C  Y N 159 
HEM C4A  C  Y N 160 
HEM CMA  C  N N 161 
HEM CAA  C  N N 162 
HEM CBA  C  N N 163 
HEM CGA  C  N N 164 
HEM O1A  O  N N 165 
HEM O2A  O  N N 166 
HEM C1B  C  N N 167 
HEM C2B  C  N N 168 
HEM C3B  C  N N 169 
HEM C4B  C  N N 170 
HEM CMB  C  N N 171 
HEM CAB  C  N N 172 
HEM CBB  C  N N 173 
HEM C1C  C  Y N 174 
HEM C2C  C  Y N 175 
HEM C3C  C  Y N 176 
HEM C4C  C  Y N 177 
HEM CMC  C  N N 178 
HEM CAC  C  N N 179 
HEM CBC  C  N N 180 
HEM C1D  C  N N 181 
HEM C2D  C  N N 182 
HEM C3D  C  N N 183 
HEM C4D  C  N N 184 
HEM CMD  C  N N 185 
HEM CAD  C  N N 186 
HEM CBD  C  N N 187 
HEM CGD  C  N N 188 
HEM O1D  O  N N 189 
HEM O2D  O  N N 190 
HEM NA   N  Y N 191 
HEM NB   N  N N 192 
HEM NC   N  Y N 193 
HEM ND   N  N N 194 
HEM FE   FE N N 195 
HEM HHB  H  N N 196 
HEM HHC  H  N N 197 
HEM HHD  H  N N 198 
HEM HMA  H  N N 199 
HEM HMAA H  N N 200 
HEM HMAB H  N N 201 
HEM HAA  H  N N 202 
HEM HAAA H  N N 203 
HEM HBA  H  N N 204 
HEM HBAA H  N N 205 
HEM HMB  H  N N 206 
HEM HMBA H  N N 207 
HEM HMBB H  N N 208 
HEM HAB  H  N N 209 
HEM HBB  H  N N 210 
HEM HBBA H  N N 211 
HEM HMC  H  N N 212 
HEM HMCA H  N N 213 
HEM HMCB H  N N 214 
HEM HAC  H  N N 215 
HEM HBC  H  N N 216 
HEM HBCA H  N N 217 
HEM HMD  H  N N 218 
HEM HMDA H  N N 219 
HEM HMDB H  N N 220 
HEM HAD  H  N N 221 
HEM HADA H  N N 222 
HEM HBD  H  N N 223 
HEM HBDA H  N N 224 
HEM H2A  H  N N 225 
HEM H2D  H  N N 226 
HEM HHA  H  N N 227 
HIS N    N  N N 228 
HIS CA   C  N S 229 
HIS C    C  N N 230 
HIS O    O  N N 231 
HIS CB   C  N N 232 
HIS CG   C  Y N 233 
HIS ND1  N  Y N 234 
HIS CD2  C  Y N 235 
HIS CE1  C  Y N 236 
HIS NE2  N  Y N 237 
HIS OXT  O  N N 238 
HIS H    H  N N 239 
HIS H2   H  N N 240 
HIS HA   H  N N 241 
HIS HB2  H  N N 242 
HIS HB3  H  N N 243 
HIS HD1  H  N N 244 
HIS HD2  H  N N 245 
HIS HE1  H  N N 246 
HIS HE2  H  N N 247 
HIS HXT  H  N N 248 
HOH O    O  N N 249 
HOH H1   H  N N 250 
HOH H2   H  N N 251 
ILE N    N  N N 252 
ILE CA   C  N S 253 
ILE C    C  N N 254 
ILE O    O  N N 255 
ILE CB   C  N S 256 
ILE CG1  C  N N 257 
ILE CG2  C  N N 258 
ILE CD1  C  N N 259 
ILE OXT  O  N N 260 
ILE H    H  N N 261 
ILE H2   H  N N 262 
ILE HA   H  N N 263 
ILE HB   H  N N 264 
ILE HG12 H  N N 265 
ILE HG13 H  N N 266 
ILE HG21 H  N N 267 
ILE HG22 H  N N 268 
ILE HG23 H  N N 269 
ILE HD11 H  N N 270 
ILE HD12 H  N N 271 
ILE HD13 H  N N 272 
ILE HXT  H  N N 273 
LEU N    N  N N 274 
LEU CA   C  N S 275 
LEU C    C  N N 276 
LEU O    O  N N 277 
LEU CB   C  N N 278 
LEU CG   C  N N 279 
LEU CD1  C  N N 280 
LEU CD2  C  N N 281 
LEU OXT  O  N N 282 
LEU H    H  N N 283 
LEU H2   H  N N 284 
LEU HA   H  N N 285 
LEU HB2  H  N N 286 
LEU HB3  H  N N 287 
LEU HG   H  N N 288 
LEU HD11 H  N N 289 
LEU HD12 H  N N 290 
LEU HD13 H  N N 291 
LEU HD21 H  N N 292 
LEU HD22 H  N N 293 
LEU HD23 H  N N 294 
LEU HXT  H  N N 295 
LYS N    N  N N 296 
LYS CA   C  N S 297 
LYS C    C  N N 298 
LYS O    O  N N 299 
LYS CB   C  N N 300 
LYS CG   C  N N 301 
LYS CD   C  N N 302 
LYS CE   C  N N 303 
LYS NZ   N  N N 304 
LYS OXT  O  N N 305 
LYS H    H  N N 306 
LYS H2   H  N N 307 
LYS HA   H  N N 308 
LYS HB2  H  N N 309 
LYS HB3  H  N N 310 
LYS HG2  H  N N 311 
LYS HG3  H  N N 312 
LYS HD2  H  N N 313 
LYS HD3  H  N N 314 
LYS HE2  H  N N 315 
LYS HE3  H  N N 316 
LYS HZ1  H  N N 317 
LYS HZ2  H  N N 318 
LYS HZ3  H  N N 319 
LYS HXT  H  N N 320 
MET N    N  N N 321 
MET CA   C  N S 322 
MET C    C  N N 323 
MET O    O  N N 324 
MET CB   C  N N 325 
MET CG   C  N N 326 
MET SD   S  N N 327 
MET CE   C  N N 328 
MET OXT  O  N N 329 
MET H    H  N N 330 
MET H2   H  N N 331 
MET HA   H  N N 332 
MET HB2  H  N N 333 
MET HB3  H  N N 334 
MET HG2  H  N N 335 
MET HG3  H  N N 336 
MET HE1  H  N N 337 
MET HE2  H  N N 338 
MET HE3  H  N N 339 
MET HXT  H  N N 340 
PHE N    N  N N 341 
PHE CA   C  N S 342 
PHE C    C  N N 343 
PHE O    O  N N 344 
PHE CB   C  N N 345 
PHE CG   C  Y N 346 
PHE CD1  C  Y N 347 
PHE CD2  C  Y N 348 
PHE CE1  C  Y N 349 
PHE CE2  C  Y N 350 
PHE CZ   C  Y N 351 
PHE OXT  O  N N 352 
PHE H    H  N N 353 
PHE H2   H  N N 354 
PHE HA   H  N N 355 
PHE HB2  H  N N 356 
PHE HB3  H  N N 357 
PHE HD1  H  N N 358 
PHE HD2  H  N N 359 
PHE HE1  H  N N 360 
PHE HE2  H  N N 361 
PHE HZ   H  N N 362 
PHE HXT  H  N N 363 
PRO N    N  N N 364 
PRO CA   C  N S 365 
PRO C    C  N N 366 
PRO O    O  N N 367 
PRO CB   C  N N 368 
PRO CG   C  N N 369 
PRO CD   C  N N 370 
PRO OXT  O  N N 371 
PRO H    H  N N 372 
PRO HA   H  N N 373 
PRO HB2  H  N N 374 
PRO HB3  H  N N 375 
PRO HG2  H  N N 376 
PRO HG3  H  N N 377 
PRO HD2  H  N N 378 
PRO HD3  H  N N 379 
PRO HXT  H  N N 380 
SER N    N  N N 381 
SER CA   C  N S 382 
SER C    C  N N 383 
SER O    O  N N 384 
SER CB   C  N N 385 
SER OG   O  N N 386 
SER OXT  O  N N 387 
SER H    H  N N 388 
SER H2   H  N N 389 
SER HA   H  N N 390 
SER HB2  H  N N 391 
SER HB3  H  N N 392 
SER HG   H  N N 393 
SER HXT  H  N N 394 
THR N    N  N N 395 
THR CA   C  N S 396 
THR C    C  N N 397 
THR O    O  N N 398 
THR CB   C  N R 399 
THR OG1  O  N N 400 
THR CG2  C  N N 401 
THR OXT  O  N N 402 
THR H    H  N N 403 
THR H2   H  N N 404 
THR HA   H  N N 405 
THR HB   H  N N 406 
THR HG1  H  N N 407 
THR HG21 H  N N 408 
THR HG22 H  N N 409 
THR HG23 H  N N 410 
THR HXT  H  N N 411 
TRP N    N  N N 412 
TRP CA   C  N S 413 
TRP C    C  N N 414 
TRP O    O  N N 415 
TRP CB   C  N N 416 
TRP CG   C  Y N 417 
TRP CD1  C  Y N 418 
TRP CD2  C  Y N 419 
TRP NE1  N  Y N 420 
TRP CE2  C  Y N 421 
TRP CE3  C  Y N 422 
TRP CZ2  C  Y N 423 
TRP CZ3  C  Y N 424 
TRP CH2  C  Y N 425 
TRP OXT  O  N N 426 
TRP H    H  N N 427 
TRP H2   H  N N 428 
TRP HA   H  N N 429 
TRP HB2  H  N N 430 
TRP HB3  H  N N 431 
TRP HD1  H  N N 432 
TRP HE1  H  N N 433 
TRP HE3  H  N N 434 
TRP HZ2  H  N N 435 
TRP HZ3  H  N N 436 
TRP HH2  H  N N 437 
TRP HXT  H  N N 438 
TYR N    N  N N 439 
TYR CA   C  N S 440 
TYR C    C  N N 441 
TYR O    O  N N 442 
TYR CB   C  N N 443 
TYR CG   C  Y N 444 
TYR CD1  C  Y N 445 
TYR CD2  C  Y N 446 
TYR CE1  C  Y N 447 
TYR CE2  C  Y N 448 
TYR CZ   C  Y N 449 
TYR OH   O  N N 450 
TYR OXT  O  N N 451 
TYR H    H  N N 452 
TYR H2   H  N N 453 
TYR HA   H  N N 454 
TYR HB2  H  N N 455 
TYR HB3  H  N N 456 
TYR HD1  H  N N 457 
TYR HD2  H  N N 458 
TYR HE1  H  N N 459 
TYR HE2  H  N N 460 
TYR HH   H  N N 461 
TYR HXT  H  N N 462 
VAL N    N  N N 463 
VAL CA   C  N S 464 
VAL C    C  N N 465 
VAL O    O  N N 466 
VAL CB   C  N N 467 
VAL CG1  C  N N 468 
VAL CG2  C  N N 469 
VAL OXT  O  N N 470 
VAL H    H  N N 471 
VAL H2   H  N N 472 
VAL HA   H  N N 473 
VAL HB   H  N N 474 
VAL HG11 H  N N 475 
VAL HG12 H  N N 476 
VAL HG13 H  N N 477 
VAL HG21 H  N N 478 
VAL HG22 H  N N 479 
VAL HG23 H  N N 480 
VAL HXT  H  N N 481 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
78U O   C    doub N N 1   
78U C   OXT  sing N N 2   
78U C   CA   sing N N 3   
78U CA  CB   sing N N 4   
78U CA  N    sing N N 5   
78U CB  CAG  sing N N 6   
78U CB  CG   sing N N 7   
78U CD1 CG   doub Y N 8   
78U CD1 NE1  sing Y N 9   
78U CG  CD2  sing Y N 10  
78U NE1 CE2  sing Y N 11  
78U CD2 CE2  doub Y N 12  
78U CD2 CE3  sing Y N 13  
78U CE2 CZ2  sing Y N 14  
78U CE3 CZ3  doub Y N 15  
78U CZ2 CH2  doub Y N 16  
78U CZ3 CH2  sing Y N 17  
78U OXT H1   sing N N 18  
78U CA  H2   sing N N 19  
78U N   H3   sing N N 20  
78U N   H4   sing N N 21  
78U CB  H6   sing N N 22  
78U CAG H7   sing N N 23  
78U CAG H8   sing N N 24  
78U CAG H9   sing N N 25  
78U CE3 H10  sing N N 26  
78U CZ3 H11  sing N N 27  
78U CH2 H12  sing N N 28  
78U CZ2 H13  sing N N 29  
78U NE1 H14  sing N N 30  
78U CD1 H15  sing N N 31  
ALA N   CA   sing N N 32  
ALA N   H    sing N N 33  
ALA N   H2   sing N N 34  
ALA CA  C    sing N N 35  
ALA CA  CB   sing N N 36  
ALA CA  HA   sing N N 37  
ALA C   O    doub N N 38  
ALA C   OXT  sing N N 39  
ALA CB  HB1  sing N N 40  
ALA CB  HB2  sing N N 41  
ALA CB  HB3  sing N N 42  
ALA OXT HXT  sing N N 43  
ARG N   CA   sing N N 44  
ARG N   H    sing N N 45  
ARG N   H2   sing N N 46  
ARG CA  C    sing N N 47  
ARG CA  CB   sing N N 48  
ARG CA  HA   sing N N 49  
ARG C   O    doub N N 50  
ARG C   OXT  sing N N 51  
ARG CB  CG   sing N N 52  
ARG CB  HB2  sing N N 53  
ARG CB  HB3  sing N N 54  
ARG CG  CD   sing N N 55  
ARG CG  HG2  sing N N 56  
ARG CG  HG3  sing N N 57  
ARG CD  NE   sing N N 58  
ARG CD  HD2  sing N N 59  
ARG CD  HD3  sing N N 60  
ARG NE  CZ   sing N N 61  
ARG NE  HE   sing N N 62  
ARG CZ  NH1  sing N N 63  
ARG CZ  NH2  doub N N 64  
ARG NH1 HH11 sing N N 65  
ARG NH1 HH12 sing N N 66  
ARG NH2 HH21 sing N N 67  
ARG NH2 HH22 sing N N 68  
ARG OXT HXT  sing N N 69  
ASN N   CA   sing N N 70  
ASN N   H    sing N N 71  
ASN N   H2   sing N N 72  
ASN CA  C    sing N N 73  
ASN CA  CB   sing N N 74  
ASN CA  HA   sing N N 75  
ASN C   O    doub N N 76  
ASN C   OXT  sing N N 77  
ASN CB  CG   sing N N 78  
ASN CB  HB2  sing N N 79  
ASN CB  HB3  sing N N 80  
ASN CG  OD1  doub N N 81  
ASN CG  ND2  sing N N 82  
ASN ND2 HD21 sing N N 83  
ASN ND2 HD22 sing N N 84  
ASN OXT HXT  sing N N 85  
ASP N   CA   sing N N 86  
ASP N   H    sing N N 87  
ASP N   H2   sing N N 88  
ASP CA  C    sing N N 89  
ASP CA  CB   sing N N 90  
ASP CA  HA   sing N N 91  
ASP C   O    doub N N 92  
ASP C   OXT  sing N N 93  
ASP CB  CG   sing N N 94  
ASP CB  HB2  sing N N 95  
ASP CB  HB3  sing N N 96  
ASP CG  OD1  doub N N 97  
ASP CG  OD2  sing N N 98  
ASP OD2 HD2  sing N N 99  
ASP OXT HXT  sing N N 100 
GLN N   CA   sing N N 101 
GLN N   H    sing N N 102 
GLN N   H2   sing N N 103 
GLN CA  C    sing N N 104 
GLN CA  CB   sing N N 105 
GLN CA  HA   sing N N 106 
GLN C   O    doub N N 107 
GLN C   OXT  sing N N 108 
GLN CB  CG   sing N N 109 
GLN CB  HB2  sing N N 110 
GLN CB  HB3  sing N N 111 
GLN CG  CD   sing N N 112 
GLN CG  HG2  sing N N 113 
GLN CG  HG3  sing N N 114 
GLN CD  OE1  doub N N 115 
GLN CD  NE2  sing N N 116 
GLN NE2 HE21 sing N N 117 
GLN NE2 HE22 sing N N 118 
GLN OXT HXT  sing N N 119 
GLU N   CA   sing N N 120 
GLU N   H    sing N N 121 
GLU N   H2   sing N N 122 
GLU CA  C    sing N N 123 
GLU CA  CB   sing N N 124 
GLU CA  HA   sing N N 125 
GLU C   O    doub N N 126 
GLU C   OXT  sing N N 127 
GLU CB  CG   sing N N 128 
GLU CB  HB2  sing N N 129 
GLU CB  HB3  sing N N 130 
GLU CG  CD   sing N N 131 
GLU CG  HG2  sing N N 132 
GLU CG  HG3  sing N N 133 
GLU CD  OE1  doub N N 134 
GLU CD  OE2  sing N N 135 
GLU OE2 HE2  sing N N 136 
GLU OXT HXT  sing N N 137 
GLY N   CA   sing N N 138 
GLY N   H    sing N N 139 
GLY N   H2   sing N N 140 
GLY CA  C    sing N N 141 
GLY CA  HA2  sing N N 142 
GLY CA  HA3  sing N N 143 
GLY C   O    doub N N 144 
GLY C   OXT  sing N N 145 
GLY OXT HXT  sing N N 146 
HEM CHA C1A  sing N N 147 
HEM CHA C4D  doub N N 148 
HEM CHA HHA  sing N N 149 
HEM CHB C4A  sing N N 150 
HEM CHB C1B  doub N N 151 
HEM CHB HHB  sing N N 152 
HEM CHC C4B  sing N N 153 
HEM CHC C1C  doub N N 154 
HEM CHC HHC  sing N N 155 
HEM CHD C4C  doub N N 156 
HEM CHD C1D  sing N N 157 
HEM CHD HHD  sing N N 158 
HEM C1A C2A  doub Y N 159 
HEM C1A NA   sing Y N 160 
HEM C2A C3A  sing Y N 161 
HEM C2A CAA  sing N N 162 
HEM C3A C4A  doub Y N 163 
HEM C3A CMA  sing N N 164 
HEM C4A NA   sing Y N 165 
HEM CMA HMA  sing N N 166 
HEM CMA HMAA sing N N 167 
HEM CMA HMAB sing N N 168 
HEM CAA CBA  sing N N 169 
HEM CAA HAA  sing N N 170 
HEM CAA HAAA sing N N 171 
HEM CBA CGA  sing N N 172 
HEM CBA HBA  sing N N 173 
HEM CBA HBAA sing N N 174 
HEM CGA O1A  doub N N 175 
HEM CGA O2A  sing N N 176 
HEM C1B C2B  sing N N 177 
HEM C1B NB   sing N N 178 
HEM C2B C3B  doub N N 179 
HEM C2B CMB  sing N N 180 
HEM C3B C4B  sing N N 181 
HEM C3B CAB  sing N N 182 
HEM C4B NB   doub N N 183 
HEM CMB HMB  sing N N 184 
HEM CMB HMBA sing N N 185 
HEM CMB HMBB sing N N 186 
HEM CAB CBB  doub N N 187 
HEM CAB HAB  sing N N 188 
HEM CBB HBB  sing N N 189 
HEM CBB HBBA sing N N 190 
HEM C1C C2C  sing Y N 191 
HEM C1C NC   sing Y N 192 
HEM C2C C3C  doub Y N 193 
HEM C2C CMC  sing N N 194 
HEM C3C C4C  sing Y N 195 
HEM C3C CAC  sing N N 196 
HEM C4C NC   sing Y N 197 
HEM CMC HMC  sing N N 198 
HEM CMC HMCA sing N N 199 
HEM CMC HMCB sing N N 200 
HEM CAC CBC  doub N N 201 
HEM CAC HAC  sing N N 202 
HEM CBC HBC  sing N N 203 
HEM CBC HBCA sing N N 204 
HEM C1D C2D  sing N N 205 
HEM C1D ND   doub N N 206 
HEM C2D C3D  doub N N 207 
HEM C2D CMD  sing N N 208 
HEM C3D C4D  sing N N 209 
HEM C3D CAD  sing N N 210 
HEM C4D ND   sing N N 211 
HEM CMD HMD  sing N N 212 
HEM CMD HMDA sing N N 213 
HEM CMD HMDB sing N N 214 
HEM CAD CBD  sing N N 215 
HEM CAD HAD  sing N N 216 
HEM CAD HADA sing N N 217 
HEM CBD CGD  sing N N 218 
HEM CBD HBD  sing N N 219 
HEM CBD HBDA sing N N 220 
HEM CGD O1D  doub N N 221 
HEM CGD O2D  sing N N 222 
HEM O2A H2A  sing N N 223 
HEM O2D H2D  sing N N 224 
HEM FE  NA   sing N N 225 
HEM FE  NB   sing N N 226 
HEM FE  NC   sing N N 227 
HEM FE  ND   sing N N 228 
HIS N   CA   sing N N 229 
HIS N   H    sing N N 230 
HIS N   H2   sing N N 231 
HIS CA  C    sing N N 232 
HIS CA  CB   sing N N 233 
HIS CA  HA   sing N N 234 
HIS C   O    doub N N 235 
HIS C   OXT  sing N N 236 
HIS CB  CG   sing N N 237 
HIS CB  HB2  sing N N 238 
HIS CB  HB3  sing N N 239 
HIS CG  ND1  sing Y N 240 
HIS CG  CD2  doub Y N 241 
HIS ND1 CE1  doub Y N 242 
HIS ND1 HD1  sing N N 243 
HIS CD2 NE2  sing Y N 244 
HIS CD2 HD2  sing N N 245 
HIS CE1 NE2  sing Y N 246 
HIS CE1 HE1  sing N N 247 
HIS NE2 HE2  sing N N 248 
HIS OXT HXT  sing N N 249 
HOH O   H1   sing N N 250 
HOH O   H2   sing N N 251 
ILE N   CA   sing N N 252 
ILE N   H    sing N N 253 
ILE N   H2   sing N N 254 
ILE CA  C    sing N N 255 
ILE CA  CB   sing N N 256 
ILE CA  HA   sing N N 257 
ILE C   O    doub N N 258 
ILE C   OXT  sing N N 259 
ILE CB  CG1  sing N N 260 
ILE CB  CG2  sing N N 261 
ILE CB  HB   sing N N 262 
ILE CG1 CD1  sing N N 263 
ILE CG1 HG12 sing N N 264 
ILE CG1 HG13 sing N N 265 
ILE CG2 HG21 sing N N 266 
ILE CG2 HG22 sing N N 267 
ILE CG2 HG23 sing N N 268 
ILE CD1 HD11 sing N N 269 
ILE CD1 HD12 sing N N 270 
ILE CD1 HD13 sing N N 271 
ILE OXT HXT  sing N N 272 
LEU N   CA   sing N N 273 
LEU N   H    sing N N 274 
LEU N   H2   sing N N 275 
LEU CA  C    sing N N 276 
LEU CA  CB   sing N N 277 
LEU CA  HA   sing N N 278 
LEU C   O    doub N N 279 
LEU C   OXT  sing N N 280 
LEU CB  CG   sing N N 281 
LEU CB  HB2  sing N N 282 
LEU CB  HB3  sing N N 283 
LEU CG  CD1  sing N N 284 
LEU CG  CD2  sing N N 285 
LEU CG  HG   sing N N 286 
LEU CD1 HD11 sing N N 287 
LEU CD1 HD12 sing N N 288 
LEU CD1 HD13 sing N N 289 
LEU CD2 HD21 sing N N 290 
LEU CD2 HD22 sing N N 291 
LEU CD2 HD23 sing N N 292 
LEU OXT HXT  sing N N 293 
LYS N   CA   sing N N 294 
LYS N   H    sing N N 295 
LYS N   H2   sing N N 296 
LYS CA  C    sing N N 297 
LYS CA  CB   sing N N 298 
LYS CA  HA   sing N N 299 
LYS C   O    doub N N 300 
LYS C   OXT  sing N N 301 
LYS CB  CG   sing N N 302 
LYS CB  HB2  sing N N 303 
LYS CB  HB3  sing N N 304 
LYS CG  CD   sing N N 305 
LYS CG  HG2  sing N N 306 
LYS CG  HG3  sing N N 307 
LYS CD  CE   sing N N 308 
LYS CD  HD2  sing N N 309 
LYS CD  HD3  sing N N 310 
LYS CE  NZ   sing N N 311 
LYS CE  HE2  sing N N 312 
LYS CE  HE3  sing N N 313 
LYS NZ  HZ1  sing N N 314 
LYS NZ  HZ2  sing N N 315 
LYS NZ  HZ3  sing N N 316 
LYS OXT HXT  sing N N 317 
MET N   CA   sing N N 318 
MET N   H    sing N N 319 
MET N   H2   sing N N 320 
MET CA  C    sing N N 321 
MET CA  CB   sing N N 322 
MET CA  HA   sing N N 323 
MET C   O    doub N N 324 
MET C   OXT  sing N N 325 
MET CB  CG   sing N N 326 
MET CB  HB2  sing N N 327 
MET CB  HB3  sing N N 328 
MET CG  SD   sing N N 329 
MET CG  HG2  sing N N 330 
MET CG  HG3  sing N N 331 
MET SD  CE   sing N N 332 
MET CE  HE1  sing N N 333 
MET CE  HE2  sing N N 334 
MET CE  HE3  sing N N 335 
MET OXT HXT  sing N N 336 
PHE N   CA   sing N N 337 
PHE N   H    sing N N 338 
PHE N   H2   sing N N 339 
PHE CA  C    sing N N 340 
PHE CA  CB   sing N N 341 
PHE CA  HA   sing N N 342 
PHE C   O    doub N N 343 
PHE C   OXT  sing N N 344 
PHE CB  CG   sing N N 345 
PHE CB  HB2  sing N N 346 
PHE CB  HB3  sing N N 347 
PHE CG  CD1  doub Y N 348 
PHE CG  CD2  sing Y N 349 
PHE CD1 CE1  sing Y N 350 
PHE CD1 HD1  sing N N 351 
PHE CD2 CE2  doub Y N 352 
PHE CD2 HD2  sing N N 353 
PHE CE1 CZ   doub Y N 354 
PHE CE1 HE1  sing N N 355 
PHE CE2 CZ   sing Y N 356 
PHE CE2 HE2  sing N N 357 
PHE CZ  HZ   sing N N 358 
PHE OXT HXT  sing N N 359 
PRO N   CA   sing N N 360 
PRO N   CD   sing N N 361 
PRO N   H    sing N N 362 
PRO CA  C    sing N N 363 
PRO CA  CB   sing N N 364 
PRO CA  HA   sing N N 365 
PRO C   O    doub N N 366 
PRO C   OXT  sing N N 367 
PRO CB  CG   sing N N 368 
PRO CB  HB2  sing N N 369 
PRO CB  HB3  sing N N 370 
PRO CG  CD   sing N N 371 
PRO CG  HG2  sing N N 372 
PRO CG  HG3  sing N N 373 
PRO CD  HD2  sing N N 374 
PRO CD  HD3  sing N N 375 
PRO OXT HXT  sing N N 376 
SER N   CA   sing N N 377 
SER N   H    sing N N 378 
SER N   H2   sing N N 379 
SER CA  C    sing N N 380 
SER CA  CB   sing N N 381 
SER CA  HA   sing N N 382 
SER C   O    doub N N 383 
SER C   OXT  sing N N 384 
SER CB  OG   sing N N 385 
SER CB  HB2  sing N N 386 
SER CB  HB3  sing N N 387 
SER OG  HG   sing N N 388 
SER OXT HXT  sing N N 389 
THR N   CA   sing N N 390 
THR N   H    sing N N 391 
THR N   H2   sing N N 392 
THR CA  C    sing N N 393 
THR CA  CB   sing N N 394 
THR CA  HA   sing N N 395 
THR C   O    doub N N 396 
THR C   OXT  sing N N 397 
THR CB  OG1  sing N N 398 
THR CB  CG2  sing N N 399 
THR CB  HB   sing N N 400 
THR OG1 HG1  sing N N 401 
THR CG2 HG21 sing N N 402 
THR CG2 HG22 sing N N 403 
THR CG2 HG23 sing N N 404 
THR OXT HXT  sing N N 405 
TRP N   CA   sing N N 406 
TRP N   H    sing N N 407 
TRP N   H2   sing N N 408 
TRP CA  C    sing N N 409 
TRP CA  CB   sing N N 410 
TRP CA  HA   sing N N 411 
TRP C   O    doub N N 412 
TRP C   OXT  sing N N 413 
TRP CB  CG   sing N N 414 
TRP CB  HB2  sing N N 415 
TRP CB  HB3  sing N N 416 
TRP CG  CD1  doub Y N 417 
TRP CG  CD2  sing Y N 418 
TRP CD1 NE1  sing Y N 419 
TRP CD1 HD1  sing N N 420 
TRP CD2 CE2  doub Y N 421 
TRP CD2 CE3  sing Y N 422 
TRP NE1 CE2  sing Y N 423 
TRP NE1 HE1  sing N N 424 
TRP CE2 CZ2  sing Y N 425 
TRP CE3 CZ3  doub Y N 426 
TRP CE3 HE3  sing N N 427 
TRP CZ2 CH2  doub Y N 428 
TRP CZ2 HZ2  sing N N 429 
TRP CZ3 CH2  sing Y N 430 
TRP CZ3 HZ3  sing N N 431 
TRP CH2 HH2  sing N N 432 
TRP OXT HXT  sing N N 433 
TYR N   CA   sing N N 434 
TYR N   H    sing N N 435 
TYR N   H2   sing N N 436 
TYR CA  C    sing N N 437 
TYR CA  CB   sing N N 438 
TYR CA  HA   sing N N 439 
TYR C   O    doub N N 440 
TYR C   OXT  sing N N 441 
TYR CB  CG   sing N N 442 
TYR CB  HB2  sing N N 443 
TYR CB  HB3  sing N N 444 
TYR CG  CD1  doub Y N 445 
TYR CG  CD2  sing Y N 446 
TYR CD1 CE1  sing Y N 447 
TYR CD1 HD1  sing N N 448 
TYR CD2 CE2  doub Y N 449 
TYR CD2 HD2  sing N N 450 
TYR CE1 CZ   doub Y N 451 
TYR CE1 HE1  sing N N 452 
TYR CE2 CZ   sing Y N 453 
TYR CE2 HE2  sing N N 454 
TYR CZ  OH   sing N N 455 
TYR OH  HH   sing N N 456 
TYR OXT HXT  sing N N 457 
VAL N   CA   sing N N 458 
VAL N   H    sing N N 459 
VAL N   H2   sing N N 460 
VAL CA  C    sing N N 461 
VAL CA  CB   sing N N 462 
VAL CA  HA   sing N N 463 
VAL C   O    doub N N 464 
VAL C   OXT  sing N N 465 
VAL CB  CG1  sing N N 466 
VAL CB  CG2  sing N N 467 
VAL CB  HB   sing N N 468 
VAL CG1 HG11 sing N N 469 
VAL CG1 HG12 sing N N 470 
VAL CG1 HG13 sing N N 471 
VAL CG2 HG21 sing N N 472 
VAL CG2 HG22 sing N N 473 
VAL CG2 HG23 sing N N 474 
VAL OXT HXT  sing N N 475 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R01GM108988      1 
'Welch Foundation'                                                                         'United States' AX-2110-20220331 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 4 2 2' 
_space_group.name_Hall        'I 4 2' 
_space_group.IT_number        97 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8VYY 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005099 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005099 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008845 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
FE  ? ? 20.90327 4.99816 ? ? 2.55100  38.46870 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366  3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 6   ? -21.13355 69.02702 -58.60160 1.000 90.36518  ? 4   SER A N   1 
ATOM   2    C  CA  . SER A 1 6   ? -21.41730 67.63020 -58.92646 1.000 104.56399 ? 4   SER A CA  1 
ATOM   3    C  C   . SER A 1 6   ? -20.30874 67.01607 -59.80121 1.000 106.86234 ? 4   SER A C   1 
ATOM   4    O  O   . SER A 1 6   ? -20.06071 67.49014 -60.91088 1.000 108.33023 ? 4   SER A O   1 
ATOM   5    C  CB  . SER A 1 6   ? -22.78967 67.50430 -59.62598 1.000 100.96796 ? 4   SER A CB  1 
ATOM   6    O  OG  . SER A 1 6   ? -22.83658 68.16679 -60.88499 1.000 100.25054 ? 4   SER A OG  1 
ATOM   7    N  N   . LEU A 1 7   ? -19.65079 65.95920 -59.29543 1.000 104.34327 ? 5   LEU A N   1 
ATOM   8    C  CA  . LEU A 1 7   ? -18.61518 65.22100 -60.02107 1.000 99.48736  ? 5   LEU A CA  1 
ATOM   9    C  C   . LEU A 1 7   ? -19.20151 64.46196 -61.21639 1.000 102.64186 ? 5   LEU A C   1 
ATOM   10   O  O   . LEU A 1 7   ? -20.34743 64.70661 -61.61689 1.000 94.77451  ? 5   LEU A O   1 
ATOM   11   C  CB  . LEU A 1 7   ? -17.87981 64.24172 -59.08405 1.000 100.88594 ? 5   LEU A CB  1 
ATOM   12   C  CG  . LEU A 1 7   ? -16.78825 64.67670 -58.09051 1.000 91.73445  ? 5   LEU A CG  1 
ATOM   13   C  CD1 . LEU A 1 7   ? -17.38970 65.01019 -56.71646 1.000 96.25571  ? 5   LEU A CD1 1 
ATOM   14   C  CD2 . LEU A 1 7   ? -15.69222 63.60435 -57.95352 1.000 70.67230  ? 5   LEU A CD2 1 
ATOM   15   N  N   . ASN A 1 8   ? -18.43125 63.51724 -61.79089 1.000 106.59311 ? 6   ASN A N   1 
ATOM   16   C  CA  . ASN A 1 8   ? -18.87392 62.81422 -62.99530 1.000 98.51164  ? 6   ASN A CA  1 
ATOM   17   C  C   . ASN A 1 8   ? -18.02763 61.57970 -63.31738 1.000 102.73295 ? 6   ASN A C   1 
ATOM   18   O  O   . ASN A 1 8   ? -16.82999 61.71320 -63.60505 1.000 110.89086 ? 6   ASN A O   1 
ATOM   19   C  CB  . ASN A 1 8   ? -18.85346 63.78508 -64.17914 1.000 103.79543 ? 6   ASN A CB  1 
ATOM   20   C  CG  . ASN A 1 8   ? -20.14559 63.76636 -64.97402 1.000 108.79061 ? 6   ASN A CG  1 
ATOM   21   O  OD1 . ASN A 1 8   ? -20.51264 62.74349 -65.55290 1.000 99.39242  ? 6   ASN A OD1 1 
ATOM   22   N  ND2 . ASN A 1 8   ? -20.84429 64.90366 -65.00720 1.000 117.11216 ? 6   ASN A ND2 1 
ATOM   23   N  N   . PRO A 1 9   ? -18.59967 60.34932 -63.26766 1.000 100.66792 ? 7   PRO A N   1 
ATOM   24   C  CA  . PRO A 1 9   ? -17.85295 59.17545 -63.75366 1.000 104.20847 ? 7   PRO A CA  1 
ATOM   25   C  C   . PRO A 1 9   ? -17.64663 59.08227 -65.26619 1.000 99.04369  ? 7   PRO A C   1 
ATOM   26   O  O   . PRO A 1 9   ? -17.11970 58.06145 -65.71688 1.000 103.11103 ? 7   PRO A O   1 
ATOM   27   C  CB  . PRO A 1 9   ? -18.69765 57.99546 -63.24216 1.000 98.68817  ? 7   PRO A CB  1 
ATOM   28   C  CG  . PRO A 1 9   ? -19.27744 58.49106 -61.97082 1.000 89.53805  ? 7   PRO A CG  1 
ATOM   29   C  CD  . PRO A 1 9   ? -19.61487 59.95464 -62.27021 1.000 100.69976 ? 7   PRO A CD  1 
ATOM   30   N  N   . ASP A 1 10  ? -18.03520 60.08873 -66.05831 1.000 96.04579  ? 8   ASP A N   1 
ATOM   31   C  CA  . ASP A 1 10  ? -17.70512 60.10792 -67.48702 1.000 106.10534 ? 8   ASP A CA  1 
ATOM   32   C  C   . ASP A 1 10  ? -17.71742 61.54772 -68.00867 1.000 109.59058 ? 8   ASP A C   1 
ATOM   33   O  O   . ASP A 1 10  ? -18.47104 62.38674 -67.51315 1.000 110.50400 ? 8   ASP A O   1 
ATOM   34   C  CB  . ASP A 1 10  ? -18.64841 59.20619 -68.31335 1.000 103.62984 ? 8   ASP A CB  1 
ATOM   35   C  CG  . ASP A 1 10  ? -20.13620 59.49481 -68.08347 1.000 97.17290  ? 8   ASP A CG  1 
ATOM   36   O  OD1 . ASP A 1 10  ? -20.53145 59.90028 -66.97024 1.000 94.43016  ? 8   ASP A OD1 1 
ATOM   37   O  OD2 . ASP A 1 10  ? -20.92083 59.28362 -69.03232 1.000 91.49228  ? 8   ASP A OD2 1 
ATOM   38   N  N   . GLU A 1 11  ? -16.85664 61.83757 -69.01818 1.000 120.89640 ? 9   GLU A N   1 
ATOM   39   C  CA  . GLU A 1 11  ? -16.64152 63.23983 -69.40139 1.000 119.75200 ? 9   GLU A CA  1 
ATOM   40   C  C   . GLU A 1 11  ? -17.23984 63.63508 -70.75449 1.000 125.74458 ? 9   GLU A C   1 
ATOM   41   O  O   . GLU A 1 11  ? -18.17043 64.45166 -70.78148 1.000 125.47549 ? 9   GLU A O   1 
ATOM   42   C  CB  . GLU A 1 11  ? -15.14712 63.59266 -69.38031 1.000 114.11291 ? 9   GLU A CB  1 
ATOM   43   C  CG  . GLU A 1 11  ? -14.46359 63.37229 -68.04873 1.000 117.24706 ? 9   GLU A CG  1 
ATOM   44   C  CD  . GLU A 1 11  ? -15.41458 63.48324 -66.87175 1.000 109.73142 ? 9   GLU A CD  1 
ATOM   45   O  OE1 . GLU A 1 11  ? -16.08120 64.53244 -66.71645 1.000 106.33340 ? 9   GLU A OE1 1 
ATOM   46   O  OE2 . GLU A 1 11  ? -15.50571 62.50014 -66.10941 1.000 106.42011 ? 9   GLU A OE2 1 
ATOM   47   N  N   . PRO A 1 12  ? -16.74419 63.12644 -71.90890 1.000 128.46041 ? 10  PRO A N   1 
ATOM   48   C  CA  . PRO A 1 12  ? -17.23294 63.67444 -73.18491 1.000 128.00357 ? 10  PRO A CA  1 
ATOM   49   C  C   . PRO A 1 12  ? -18.47692 62.95592 -73.69421 1.000 126.83058 ? 10  PRO A C   1 
ATOM   50   O  O   . PRO A 1 12  ? -18.35894 61.91553 -74.35234 1.000 128.75950 ? 10  PRO A O   1 
ATOM   51   C  CB  . PRO A 1 12  ? -16.03512 63.47680 -74.12711 1.000 124.92761 ? 10  PRO A CB  1 
ATOM   52   C  CG  . PRO A 1 12  ? -15.21058 62.34083 -73.49609 1.000 125.77861 ? 10  PRO A CG  1 
ATOM   53   C  CD  . PRO A 1 12  ? -15.81870 62.00140 -72.14751 1.000 122.56859 ? 10  PRO A CD  1 
ATOM   54   N  N   . ASN A 1 13  ? -19.67085 63.48984 -73.41765 1.000 117.92879 ? 11  ASN A N   1 
ATOM   55   C  CA  . ASN A 1 13  ? -20.89756 62.75701 -73.70854 1.000 121.39462 ? 11  ASN A CA  1 
ATOM   56   C  C   . ASN A 1 13  ? -21.99025 63.69394 -74.22123 1.000 116.45794 ? 11  ASN A C   1 
ATOM   57   O  O   . ASN A 1 13  ? -21.80438 64.91178 -74.35042 1.000 102.43095 ? 11  ASN A O   1 
ATOM   58   C  CB  . ASN A 1 13  ? -21.39188 61.98912 -72.47076 1.000 117.39532 ? 11  ASN A CB  1 
ATOM   59   C  CG  . ASN A 1 13  ? -20.78175 60.59777 -72.35718 1.000 111.14327 ? 11  ASN A CG  1 
ATOM   60   O  OD1 . ASN A 1 13  ? -19.69279 60.43192 -71.80428 1.000 111.99771 ? 11  ASN A OD1 1 
ATOM   61   N  ND2 . ASN A 1 13  ? -21.47937 59.59216 -72.88943 1.000 99.29679  ? 11  ASN A ND2 1 
ATOM   62   N  N   . ALA A 1 14  ? -23.14526 63.08250 -74.51306 1.000 115.26051 ? 12  ALA A N   1 
ATOM   63   C  CA  . ALA A 1 14  ? -24.36715 63.75614 -74.93312 1.000 105.36698 ? 12  ALA A CA  1 
ATOM   64   C  C   . ALA A 1 14  ? -25.21205 64.17282 -73.73548 1.000 106.09321 ? 12  ALA A C   1 
ATOM   65   O  O   . ALA A 1 14  ? -26.44582 64.15900 -73.81481 1.000 100.43109 ? 12  ALA A O   1 
ATOM   66   C  CB  . ALA A 1 14  ? -25.18931 62.84974 -75.84979 1.000 87.02209  ? 12  ALA A CB  1 
ATOM   67   N  N   . LEU A 1 15  ? -24.54963 64.47363 -72.61091 1.000 98.75917  ? 13  LEU A N   1 
ATOM   68   C  CA  . LEU A 1 15  ? -25.10882 65.27337 -71.52150 1.000 101.47206 ? 13  LEU A CA  1 
ATOM   69   C  C   . LEU A 1 15  ? -26.19400 64.54150 -70.72564 1.000 99.28093  ? 13  LEU A C   1 
ATOM   70   O  O   . LEU A 1 15  ? -26.12736 64.47728 -69.48980 1.000 87.99332  ? 13  LEU A O   1 
ATOM   71   C  CB  . LEU A 1 15  ? -25.64136 66.60605 -72.07753 1.000 110.92223 ? 13  LEU A CB  1 
ATOM   72   C  CG  . LEU A 1 15  ? -24.68260 67.77473 -72.41862 1.000 116.04562 ? 13  LEU A CG  1 
ATOM   73   C  CD1 . LEU A 1 15  ? -23.46037 67.37096 -73.26268 1.000 105.56237 ? 13  LEU A CD1 1 
ATOM   74   C  CD2 . LEU A 1 15  ? -25.44065 68.92420 -73.10520 1.000 100.80320 ? 13  LEU A CD2 1 
ATOM   75   N  N   . LEU A 1 16  ? -27.20558 63.99850 -71.41331 1.000 96.12872  ? 14  LEU A N   1 
ATOM   76   C  CA  . LEU A 1 16  ? -28.17652 63.11086 -70.77546 1.000 83.65020  ? 14  LEU A CA  1 
ATOM   77   C  C   . LEU A 1 16  ? -27.61040 61.72716 -70.49382 1.000 84.75224  ? 14  LEU A C   1 
ATOM   78   O  O   . LEU A 1 16  ? -28.34875 60.85982 -70.00697 1.000 71.54179  ? 14  LEU A O   1 
ATOM   79   C  CB  . LEU A 1 16  ? -29.42295 62.94883 -71.64639 1.000 90.06149  ? 14  LEU A CB  1 
ATOM   80   C  CG  . LEU A 1 16  ? -30.36920 64.11580 -71.89620 1.000 87.43212  ? 14  LEU A CG  1 
ATOM   81   C  CD1 . LEU A 1 16  ? -30.53797 64.31345 -73.40739 1.000 77.36553  ? 14  LEU A CD1 1 
ATOM   82   C  CD2 . LEU A 1 16  ? -31.70564 63.84678 -71.20469 1.000 79.64509  ? 14  LEU A CD2 1 
ATOM   83   N  N   . SER A 1 17  ? -26.34019 61.48729 -70.81891 1.000 82.88381  ? 15  SER A N   1 
ATOM   84   C  CA  . SER A 1 17  ? -25.69235 60.20971 -70.56996 1.000 76.28184  ? 15  SER A CA  1 
ATOM   85   C  C   . SER A 1 17  ? -24.60025 60.33154 -69.50266 1.000 76.60980  ? 15  SER A C   1 
ATOM   86   O  O   . SER A 1 17  ? -23.68185 59.51115 -69.44729 1.000 71.99971  ? 15  SER A O   1 
ATOM   87   C  CB  . SER A 1 17  ? -25.15109 59.64377 -71.88531 1.000 80.83652  ? 15  SER A CB  1 
ATOM   88   O  OG  . SER A 1 17  ? -26.22381 59.31984 -72.77072 1.000 67.67965  ? 15  SER A OG  1 
ATOM   89   N  N   . TYR A 1 18  ? -24.71041 61.34506 -68.63870 1.000 80.30423  ? 16  TYR A N   1 
ATOM   90   C  CA  . TYR A 1 18  ? -23.80775 61.61510 -67.52379 1.000 87.91266  ? 16  TYR A CA  1 
ATOM   91   C  C   . TYR A 1 18  ? -24.26601 60.88650 -66.25145 1.000 84.95952  ? 16  TYR A C   1 
ATOM   92   O  O   . TYR A 1 18  ? -25.42012 60.46963 -66.13415 1.000 85.47115  ? 16  TYR A O   1 
ATOM   93   C  CB  . TYR A 1 18  ? -23.76143 63.11772 -67.23201 1.000 92.66076  ? 16  TYR A CB  1 
ATOM   94   C  CG  . TYR A 1 18  ? -22.70810 63.92251 -67.96401 1.000 112.00778 ? 16  TYR A CG  1 
ATOM   95   C  CD1 . TYR A 1 18  ? -21.48821 63.36164 -68.31385 1.000 118.73994 ? 16  TYR A CD1 1 
ATOM   96   C  CD2 . TYR A 1 18  ? -22.91656 65.27614 -68.25717 1.000 121.08926 ? 16  TYR A CD2 1 
ATOM   97   C  CE1 . TYR A 1 18  ? -20.51505 64.11180 -68.97199 1.000 125.56851 ? 16  TYR A CE1 1 
ATOM   98   C  CE2 . TYR A 1 18  ? -21.94587 66.03592 -68.91194 1.000 118.85130 ? 16  TYR A CE2 1 
ATOM   99   C  CZ  . TYR A 1 18  ? -20.74763 65.44656 -69.26568 1.000 127.43677 ? 16  TYR A CZ  1 
ATOM   100  O  OH  . TYR A 1 18  ? -19.78168 66.18685 -69.91358 1.000 129.86134 ? 16  TYR A OH  1 
ATOM   101  N  N   . ASP A 1 19  ? -23.34199 60.77353 -65.27891 1.000 85.71742  ? 17  ASP A N   1 
ATOM   102  C  CA  . ASP A 1 19  ? -23.56346 60.27744 -63.91313 1.000 82.06080  ? 17  ASP A CA  1 
ATOM   103  C  C   . ASP A 1 19  ? -23.00585 61.32492 -62.93470 1.000 80.67865  ? 17  ASP A C   1 
ATOM   104  O  O   . ASP A 1 19  ? -21.94072 61.88230 -63.19897 1.000 91.15381  ? 17  ASP A O   1 
ATOM   105  C  CB  . ASP A 1 19  ? -22.85687 58.87296 -63.74470 1.000 79.97723  ? 17  ASP A CB  1 
ATOM   106  C  CG  . ASP A 1 19  ? -23.54134 57.93462 -62.71015 1.000 82.50831  ? 17  ASP A CG  1 
ATOM   107  O  OD1 . ASP A 1 19  ? -23.17096 58.00225 -61.50385 1.000 67.01466  ? 17  ASP A OD1 1 
ATOM   108  O  OD2 . ASP A 1 19  ? -24.40015 57.08953 -63.09749 1.000 67.77429  ? 17  ASP A OD2 1 
ATOM   109  N  N   . PHE A 1 20  ? -23.69371 61.60574 -61.79798 1.000 90.10026  ? 18  PHE A N   1 
ATOM   110  C  CA  . PHE A 1 20  ? -23.36135 62.76465 -60.94719 1.000 87.32725  ? 18  PHE A CA  1 
ATOM   111  C  C   . PHE A 1 20  ? -23.19485 62.41001 -59.45843 1.000 89.99034  ? 18  PHE A C   1 
ATOM   112  O  O   . PHE A 1 20  ? -23.82000 61.46280 -58.98128 1.000 94.79991  ? 18  PHE A O   1 
ATOM   113  C  CB  . PHE A 1 20  ? -24.45236 63.84394 -61.09304 1.000 90.34662  ? 18  PHE A CB  1 
ATOM   114  C  CG  . PHE A 1 20  ? -24.51378 64.49066 -62.46813 1.000 95.21245  ? 18  PHE A CG  1 
ATOM   115  C  CD1 . PHE A 1 20  ? -25.31789 63.95998 -63.46522 1.000 92.48803  ? 18  PHE A CD1 1 
ATOM   116  C  CD2 . PHE A 1 20  ? -23.78875 65.64959 -62.74946 1.000 109.70655 ? 18  PHE A CD2 1 
ATOM   117  C  CE1 . PHE A 1 20  ? -25.39514 64.56270 -64.72293 1.000 96.46408  ? 18  PHE A CE1 1 
ATOM   118  C  CE2 . PHE A 1 20  ? -23.85385 66.25580 -64.00823 1.000 105.09225 ? 18  PHE A CE2 1 
ATOM   119  C  CZ  . PHE A 1 20  ? -24.65793 65.70821 -64.99388 1.000 103.22745 ? 18  PHE A CZ  1 
ATOM   120  N  N   . ASP A 1 21  ? -22.36631 63.19707 -58.71085 1.000 91.39595  ? 19  ASP A N   1 
ATOM   121  C  CA  . ASP A 1 21  ? -22.05864 62.99320 -57.27019 1.000 85.66716  ? 19  ASP A CA  1 
ATOM   122  C  C   . ASP A 1 21  ? -21.97744 64.33537 -56.51955 1.000 95.68536  ? 19  ASP A C   1 
ATOM   123  O  O   . ASP A 1 21  ? -20.94168 65.00293 -56.60122 1.000 101.91953 ? 19  ASP A O   1 
ATOM   124  C  CB  . ASP A 1 21  ? -20.70946 62.27764 -57.06513 1.000 98.84212  ? 19  ASP A CB  1 
ATOM   125  C  CG  . ASP A 1 21  ? -20.45589 61.10076 -58.02034 1.000 92.50491  ? 19  ASP A CG  1 
ATOM   126  O  OD1 . ASP A 1 21  ? -21.40708 60.49414 -58.54376 1.000 82.64755  ? 19  ASP A OD1 1 
ATOM   127  O  OD2 . ASP A 1 21  ? -19.25886 60.79855 -58.25702 1.000 81.05018  ? 19  ASP A OD2 1 
ATOM   128  N  N   . ARG A 1 22  ? -22.99020 64.69859 -55.67402 1.000 94.78525  ? 20  ARG A N   1 
ATOM   129  C  CA  . ARG A 1 22  ? -23.26165 66.12842 -55.44684 1.000 79.49004  ? 20  ARG A CA  1 
ATOM   130  C  C   . ARG A 1 22  ? -23.76228 66.54345 -54.04188 1.000 85.54566  ? 20  ARG A C   1 
ATOM   131  O  O   . ARG A 1 22  ? -24.56146 67.48151 -53.93691 1.000 79.35990  ? 20  ARG A O   1 
ATOM   132  C  CB  . ARG A 1 22  ? -24.30215 66.60283 -56.47092 1.000 90.38919  ? 20  ARG A CB  1 
ATOM   133  C  CG  . ARG A 1 22  ? -25.60608 65.84373 -56.35083 1.000 86.86457  ? 20  ARG A CG  1 
ATOM   134  C  CD  . ARG A 1 22  ? -26.42313 65.79468 -57.63864 1.000 86.15829  ? 20  ARG A CD  1 
ATOM   135  N  NE  . ARG A 1 22  ? -27.54847 66.71996 -57.56498 1.000 94.25879  ? 20  ARG A NE  1 
ATOM   136  C  CZ  . ARG A 1 22  ? -28.59899 66.57002 -56.76401 1.000 97.35554  ? 20  ARG A CZ  1 
ATOM   137  N  NH1 . ARG A 1 22  ? -28.69915 65.54008 -55.93209 1.000 90.12991  ? 20  ARG A NH1 1 
ATOM   138  N  NH2 . ARG A 1 22  ? -29.56372 67.48867 -56.77959 1.000 93.31282  ? 20  ARG A NH2 1 
ATOM   139  N  N   . GLY A 1 23  ? -23.30772 65.90279 -52.96354 1.000 84.33057  ? 21  GLY A N   1 
ATOM   140  C  CA  . GLY A 1 23  ? -23.36867 66.52551 -51.64011 1.000 76.67376  ? 21  GLY A CA  1 
ATOM   141  C  C   . GLY A 1 23  ? -24.69002 66.54782 -50.87366 1.000 77.37498  ? 21  GLY A C   1 
ATOM   142  O  O   . GLY A 1 23  ? -24.78288 67.27098 -49.87194 1.000 71.34109  ? 21  GLY A O   1 
ATOM   143  N  N   . SER A 1 24  ? -25.70274 65.77815 -51.27171 1.000 73.73437  ? 22  SER A N   1 
ATOM   144  C  CA  . SER A 1 24  ? -26.95027 65.71290 -50.51090 1.000 66.88065  ? 22  SER A CA  1 
ATOM   145  C  C   . SER A 1 24  ? -26.74877 64.94803 -49.20037 1.000 68.29942  ? 22  SER A C   1 
ATOM   146  O  O   . SER A 1 24  ? -25.72392 64.30000 -48.98085 1.000 69.09917  ? 22  SER A O   1 
ATOM   147  C  CB  . SER A 1 24  ? -28.04826 65.03397 -51.33085 1.000 69.67981  ? 22  SER A CB  1 
ATOM   148  O  OG  . SER A 1 24  ? -27.70226 63.68631 -51.62267 1.000 66.89501  ? 22  SER A OG  1 
ATOM   149  N  N   . ASN A 1 25  ? -27.75660 65.00696 -48.32053 1.000 65.87187  ? 23  ASN A N   1 
ATOM   150  C  CA  . ASN A 1 25  ? -27.64818 64.26905 -47.06303 1.000 66.85310  ? 23  ASN A CA  1 
ATOM   151  C  C   . ASN A 1 25  ? -27.76856 62.76441 -47.27555 1.000 67.33764  ? 23  ASN A C   1 
ATOM   152  O  O   . ASN A 1 25  ? -27.14761 61.98530 -46.54088 1.000 57.98978  ? 23  ASN A O   1 
ATOM   153  C  CB  . ASN A 1 25  ? -28.69707 64.74073 -46.05614 1.000 71.19895  ? 23  ASN A CB  1 
ATOM   154  C  CG  . ASN A 1 25  ? -28.25503 65.97592 -45.30676 1.000 86.40631  ? 23  ASN A CG  1 
ATOM   155  O  OD1 . ASN A 1 25  ? -27.14456 66.01738 -44.75938 1.000 81.00500  ? 23  ASN A OD1 1 
ATOM   156  N  ND2 . ASN A 1 25  ? -29.13118 66.98096 -45.24466 1.000 87.12966  ? 23  ASN A ND2 1 
ATOM   157  N  N   . TYR A 1 26  ? -28.57212 62.34172 -48.25515 1.000 60.03297  ? 24  TYR A N   1 
ATOM   158  C  CA  . TYR A 1 26  ? -28.60555 60.93730 -48.64673 1.000 60.51775  ? 24  TYR A CA  1 
ATOM   159  C  C   . TYR A 1 26  ? -27.20083 60.41817 -48.94629 1.000 59.09446  ? 24  TYR A C   1 
ATOM   160  O  O   . TYR A 1 26  ? -26.80878 59.35298 -48.45886 1.000 58.29967  ? 24  TYR A O   1 
ATOM   161  C  CB  . TYR A 1 26  ? -29.52779 60.76175 -49.86042 1.000 62.63925  ? 24  TYR A CB  1 
ATOM   162  C  CG  . TYR A 1 26  ? -29.54085 59.36935 -50.43637 1.000 57.87034  ? 24  TYR A CG  1 
ATOM   163  C  CD1 . TYR A 1 26  ? -30.41931 58.39937 -49.94090 1.000 51.61072  ? 24  TYR A CD1 1 
ATOM   164  C  CD2 . TYR A 1 26  ? -28.67561 59.02007 -51.47965 1.000 50.13485  ? 24  TYR A CD2 1 
ATOM   165  C  CE1 . TYR A 1 26  ? -30.43933 57.11884 -50.46638 1.000 51.42395  ? 24  TYR A CE1 1 
ATOM   166  C  CE2 . TYR A 1 26  ? -28.67828 57.74568 -52.00664 1.000 49.76863  ? 24  TYR A CE2 1 
ATOM   167  C  CZ  . TYR A 1 26  ? -29.56546 56.79908 -51.50085 1.000 55.00847  ? 24  TYR A CZ  1 
ATOM   168  O  OH  . TYR A 1 26  ? -29.56627 55.53324 -52.02452 1.000 51.05433  ? 24  TYR A OH  1 
ATOM   169  N  N   . GLU A 1 27  ? -26.42058 61.17524 -49.73340 1.000 57.57281  ? 25  GLU A N   1 
ATOM   170  C  CA  . GLU A 1 27  ? -25.04643 60.77660 -50.05406 1.000 61.74963  ? 25  GLU A CA  1 
ATOM   171  C  C   . GLU A 1 27  ? -24.11827 60.87831 -48.83811 1.000 64.54036  ? 25  GLU A C   1 
ATOM   172  O  O   . GLU A 1 27  ? -23.24021 60.02240 -48.65189 1.000 60.12487  ? 25  GLU A O   1 
ATOM   173  C  CB  . GLU A 1 27  ? -24.50661 61.63583 -51.19806 1.000 60.80380  ? 25  GLU A CB  1 
ATOM   174  C  CG  . GLU A 1 27  ? -25.07450 61.29522 -52.55866 1.000 66.47384  ? 25  GLU A CG  1 
ATOM   175  C  CD  . GLU A 1 27  ? -24.85066 62.40292 -53.58921 1.000 79.73798  ? 25  GLU A CD  1 
ATOM   176  O  OE1 . GLU A 1 27  ? -25.50742 63.46106 -53.47377 1.000 72.38524  ? 25  GLU A OE1 1 
ATOM   177  O  OE2 . GLU A 1 27  ? -24.03699 62.20337 -54.52759 1.000 82.60959  ? 25  GLU A OE2 1 
ATOM   178  N  N   . ASN A 1 28  ? -24.28783 61.92207 -48.00968 1.000 58.27205  ? 26  ASN A N   1 
ATOM   179  C  CA  . ASN A 1 28  ? -23.43749 62.11305 -46.83130 1.000 57.43141  ? 26  ASN A CA  1 
ATOM   180  C  C   . ASN A 1 28  ? -23.57719 60.95481 -45.85062 1.000 55.35794  ? 26  ASN A C   1 
ATOM   181  O  O   . ASN A 1 28  ? -22.57905 60.41209 -45.36340 1.000 53.40022  ? 26  ASN A O   1 
ATOM   182  C  CB  . ASN A 1 28  ? -23.78779 63.42843 -46.11835 1.000 70.46187  ? 26  ASN A CB  1 
ATOM   183  C  CG  . ASN A 1 28  ? -23.43466 64.67265 -46.93493 1.000 72.25923  ? 26  ASN A CG  1 
ATOM   184  O  OD1 . ASN A 1 28  ? -22.57349 64.63138 -47.81916 1.000 72.19763  ? 26  ASN A OD1 1 
ATOM   185  N  ND2 . ASN A 1 28  ? -24.11592 65.78668 -46.64108 1.000 67.07131  ? 26  ASN A ND2 1 
ATOM   186  N  N   . VAL A 1 29  ? -24.81803 60.58505 -45.52666 1.000 56.33398  ? 27  VAL A N   1 
ATOM   187  C  CA  . VAL A 1 29  ? -25.06839 59.52459 -44.55605 1.000 59.44964  ? 27  VAL A CA  1 
ATOM   188  C  C   . VAL A 1 29  ? -24.48512 58.20031 -45.04238 1.000 61.22157  ? 27  VAL A C   1 
ATOM   189  O  O   . VAL A 1 29  ? -23.98067 57.40119 -44.24099 1.000 55.15505  ? 27  VAL A O   1 
ATOM   190  C  CB  . VAL A 1 29  ? -26.58732 59.42343 -44.28098 1.000 63.54560  ? 27  VAL A CB  1 
ATOM   191  C  CG1 . VAL A 1 29  ? -26.93046 58.19579 -43.43378 1.000 61.98242  ? 27  VAL A CG1 1 
ATOM   192  C  CG2 . VAL A 1 29  ? -27.08366 60.68848 -43.62257 1.000 60.16751  ? 27  VAL A CG2 1 
ATOM   193  N  N   . LEU A 1 30  ? -24.51460 57.95249 -46.35373 1.000 52.48001  ? 28  LEU A N   1 
ATOM   194  C  CA  . LEU A 1 30  ? -24.08860 56.65648 -46.86084 1.000 54.67524  ? 28  LEU A CA  1 
ATOM   195  C  C   . LEU A 1 30  ? -22.60187 56.58622 -47.19751 1.000 58.58613  ? 28  LEU A C   1 
ATOM   196  O  O   . LEU A 1 30  ? -22.09925 55.47569 -47.42133 1.000 50.62570  ? 28  LEU A O   1 
ATOM   197  C  CB  . LEU A 1 30  ? -24.91609 56.26401 -48.09137 1.000 47.16091  ? 28  LEU A CB  1 
ATOM   198  C  CG  . LEU A 1 30  ? -26.41687 56.04056 -47.84457 1.000 50.17225  ? 28  LEU A CG  1 
ATOM   199  C  CD1 . LEU A 1 30  ? -27.17913 55.90626 -49.15118 1.000 46.32458  ? 28  LEU A CD1 1 
ATOM   200  C  CD2 . LEU A 1 30  ? -26.66963 54.84775 -46.93925 1.000 48.94531  ? 28  LEU A CD2 1 
ATOM   201  N  N   . HIS A 1 31  ? -21.88281 57.72202 -47.19401 1.000 51.82884  ? 29  HIS A N   1 
ATOM   202  C  CA  . HIS A 1 31  ? -20.51261 57.80324 -47.72017 1.000 46.43052  ? 29  HIS A CA  1 
ATOM   203  C  C   . HIS A 1 31  ? -20.47231 57.35912 -49.17593 1.000 49.02108  ? 29  HIS A C   1 
ATOM   204  O  O   . HIS A 1 31  ? -19.50957 56.73225 -49.62213 1.000 55.89251  ? 29  HIS A O   1 
ATOM   205  C  CB  . HIS A 1 31  ? -19.50533 56.96864 -46.91174 1.000 54.02234  ? 29  HIS A CB  1 
ATOM   206  C  CG  . HIS A 1 31  ? -19.36556 57.36421 -45.47173 1.000 61.01062  ? 29  HIS A CG  1 
ATOM   207  N  ND1 . HIS A 1 31  ? -20.39852 57.90156 -44.73069 1.000 65.33805  ? 29  HIS A ND1 1 
ATOM   208  C  CD2 . HIS A 1 31  ? -18.31343 57.25910 -44.62421 1.000 72.50135  ? 29  HIS A CD2 1 
ATOM   209  C  CE1 . HIS A 1 31  ? -19.98385 58.12692 -43.49677 1.000 64.47138  ? 29  HIS A CE1 1 
ATOM   210  N  NE2 . HIS A 1 31  ? -18.72366 57.74250 -43.40466 1.000 72.65708  ? 29  HIS A NE2 1 
ATOM   211  N  N   . LEU A 1 32  ? -21.53271 57.67201 -49.91576 1.000 49.90800  ? 30  LEU A N   1 
ATOM   212  C  CA  . LEU A 1 32  ? -21.69731 57.13925 -51.26090 1.000 52.51165  ? 30  LEU A CA  1 
ATOM   213  C  C   . LEU A 1 32  ? -20.58808 57.61596 -52.19328 1.000 56.11624  ? 30  LEU A C   1 
ATOM   214  O  O   . LEU A 1 32  ? -20.09440 56.84758 -53.03217 1.000 50.15578  ? 30  LEU A O   1 
ATOM   215  C  CB  . LEU A 1 32  ? -23.07023 57.54001 -51.79701 1.000 53.54465  ? 30  LEU A CB  1 
ATOM   216  C  CG  . LEU A 1 32  ? -23.51213 56.98242 -53.14827 1.000 52.60620  ? 30  LEU A CG  1 
ATOM   217  C  CD1 . LEU A 1 32  ? -23.28193 55.48827 -53.19592 1.000 56.20967  ? 30  LEU A CD1 1 
ATOM   218  C  CD2 . LEU A 1 32  ? -24.97066 57.29877 -53.35633 1.000 51.90751  ? 30  LEU A CD2 1 
ATOM   219  N  N   . THR A 1 33  ? -20.17174 58.87424 -52.05422 1.000 51.70272  ? 31  THR A N   1 
ATOM   220  C  CA  . THR A 1 33  ? -19.16430 59.40880 -52.96388 1.000 57.13003  ? 31  THR A CA  1 
ATOM   221  C  C   . THR A 1 33  ? -17.83269 58.68698 -52.77896 1.000 57.97903  ? 31  THR A C   1 
ATOM   222  O  O   . THR A 1 33  ? -17.13268 58.41307 -53.76307 1.000 57.96153  ? 31  THR A O   1 
ATOM   223  C  CB  . THR A 1 33  ? -19.01937 60.92100 -52.75654 1.000 58.63203  ? 31  THR A CB  1 
ATOM   224  O  OG1 . THR A 1 33  ? -20.29470 61.54380 -52.95814 1.000 62.25600  ? 31  THR A OG1 1 
ATOM   225  C  CG2 . THR A 1 33  ? -18.06706 61.50582 -53.77404 1.000 51.95677  ? 31  THR A CG2 1 
ATOM   226  N  N   . ASP A 1 34  ? -17.48356 58.33826 -51.52968 1.000 57.25682  ? 32  ASP A N   1 
ATOM   227  C  CA  . ASP A 1 34  ? -16.31651 57.48772 -51.29777 1.000 56.02340  ? 32  ASP A CA  1 
ATOM   228  C  C   . ASP A 1 34  ? -16.47080 56.15754 -52.01944 1.000 60.02538  ? 32  ASP A C   1 
ATOM   229  O  O   . ASP A 1 34  ? -15.54687 55.69495 -52.69895 1.000 64.48901  ? 32  ASP A O   1 
ATOM   230  C  CB  . ASP A 1 34  ? -16.09597 57.23462 -49.79971 1.000 64.64070  ? 32  ASP A CB  1 
ATOM   231  C  CG  . ASP A 1 34  ? -15.74309 58.50287 -49.01061 1.000 83.37747  ? 32  ASP A CG  1 
ATOM   232  O  OD1 . ASP A 1 34  ? -15.13000 59.43797 -49.58562 1.000 83.78622  ? 32  ASP A OD1 1 
ATOM   233  O  OD2 . ASP A 1 34  ? -16.06736 58.55162 -47.79466 1.000 85.84112  ? 32  ASP A OD2 1 
ATOM   234  N  N   . ALA A 1 35  ? -17.64179 55.52603 -51.88508 1.000 52.55648  ? 33  ALA A N   1 
ATOM   235  C  CA  . ALA A 1 35  ? -17.81614 54.18720 -52.43652 1.000 54.76924  ? 33  ALA A CA  1 
ATOM   236  C  C   . ALA A 1 35  ? -17.74829 54.19909 -53.96430 1.000 54.74902  ? 33  ALA A C   1 
ATOM   237  O  O   . ALA A 1 35  ? -17.12721 53.31631 -54.56982 1.000 53.79074  ? 33  ALA A O   1 
ATOM   238  C  CB  . ALA A 1 35  ? -19.13191 53.58021 -51.93295 1.000 45.60870  ? 33  ALA A CB  1 
ATOM   239  N  N   . LEU A 1 36  ? -18.37035 55.19051 -54.60838 1.000 50.67211  ? 34  LEU A N   1 
ATOM   240  C  CA  . LEU A 1 36  ? -18.30241 55.26690 -56.06169 1.000 51.29058  ? 34  LEU A CA  1 
ATOM   241  C  C   . LEU A 1 36  ? -16.90570 55.61869 -56.53657 1.000 57.79262  ? 34  LEU A C   1 
ATOM   242  O  O   . LEU A 1 36  ? -16.54906 55.27997 -57.67145 1.000 56.48312  ? 34  LEU A O   1 
ATOM   243  C  CB  . LEU A 1 36  ? -19.30920 56.28638 -56.59362 1.000 47.35392  ? 34  LEU A CB  1 
ATOM   244  C  CG  . LEU A 1 36  ? -20.75281 55.92494 -56.25443 1.000 53.36103  ? 34  LEU A CG  1 
ATOM   245  C  CD1 . LEU A 1 36  ? -21.71842 57.03415 -56.63505 1.000 51.31964  ? 34  LEU A CD1 1 
ATOM   246  C  CD2 . LEU A 1 36  ? -21.12118 54.61576 -56.91523 1.000 52.13141  ? 34  LEU A CD2 1 
ATOM   247  N  N   . GLY A 1 37  ? -16.11065 56.27799 -55.68540 1.000 55.79240  ? 35  GLY A N   1 
ATOM   248  C  CA  . GLY A 1 37  ? -14.73357 56.58959 -56.01567 1.000 55.97283  ? 35  GLY A CA  1 
ATOM   249  C  C   . GLY A 1 37  ? -13.88351 55.37369 -56.32134 1.000 56.54344  ? 35  GLY A C   1 
ATOM   250  O  O   . GLY A 1 37  ? -12.89440 55.48879 -57.05198 1.000 64.35708  ? 35  GLY A O   1 
ATOM   251  N  N   . ALA A 1 38  ? -14.25301 54.20772 -55.79408 1.000 47.72744  ? 36  ALA A N   1 
ATOM   252  C  CA  . ALA A 1 38  ? -13.49688 52.98547 -56.03319 1.000 56.02984  ? 36  ALA A CA  1 
ATOM   253  C  C   . ALA A 1 38  ? -13.68486 52.42431 -57.43682 1.000 55.49735  ? 36  ALA A C   1 
ATOM   254  O  O   . ALA A 1 38  ? -12.89037 51.57188 -57.85488 1.000 54.54885  ? 36  ALA A O   1 
ATOM   255  C  CB  . ALA A 1 38  ? -13.87668 51.91238 -55.00542 1.000 54.49889  ? 36  ALA A CB  1 
ATOM   256  N  N   . LEU A 1 39  ? -14.69697 52.86670 -58.17509 1.000 46.53141  ? 37  LEU A N   1 
ATOM   257  C  CA  . LEU A 1 39  ? -14.88325 52.34301 -59.51883 1.000 57.78817  ? 37  LEU A CA  1 
ATOM   258  C  C   . LEU A 1 39  ? -13.70463 52.74223 -60.39917 1.000 57.74910  ? 37  LEU A C   1 
ATOM   259  O  O   . LEU A 1 39  ? -13.17314 53.84914 -60.28308 1.000 63.36767  ? 37  LEU A O   1 
ATOM   260  C  CB  . LEU A 1 39  ? -16.20894 52.83164 -60.10917 1.000 51.12397  ? 37  LEU A CB  1 
ATOM   261  C  CG  . LEU A 1 39  ? -17.44021 52.26370 -59.39790 1.000 54.29903  ? 37  LEU A CG  1 
ATOM   262  C  CD1 . LEU A 1 39  ? -18.71235 52.75547 -60.04459 1.000 60.47720  ? 37  LEU A CD1 1 
ATOM   263  C  CD2 . LEU A 1 39  ? -17.41117 50.74786 -59.36211 1.000 54.81185  ? 37  LEU A CD2 1 
ATOM   264  N  N   . VAL A 1 40  ? -13.26636 51.81676 -61.24907 1.000 63.71058  ? 38  VAL A N   1 
ATOM   265  C  CA  . VAL A 1 40  ? -12.15161 52.12998 -62.15571 1.000 66.34240  ? 38  VAL A CA  1 
ATOM   266  C  C   . VAL A 1 40  ? -12.57431 53.26289 -63.08467 1.000 68.72653  ? 38  VAL A C   1 
ATOM   267  O  O   . VAL A 1 40  ? -13.65822 53.18610 -63.70413 1.000 65.75333  ? 38  VAL A O   1 
ATOM   268  C  CB  . VAL A 1 40  ? -11.72339 50.88024 -62.95718 1.000 66.57353  ? 38  VAL A CB  1 
ATOM   269  C  CG1 . VAL A 1 40  ? -10.70811 51.24448 -64.03893 1.000 65.45014  ? 38  VAL A CG1 1 
ATOM   270  C  CG2 . VAL A 1 40  ? -11.12936 49.82909 -62.02810 1.000 67.51476  ? 38  VAL A CG2 1 
ATOM   271  N  N   . PRO A 1 41  ? -11.78995 54.33783 -63.19067 1.000 72.55075  ? 39  PRO A N   1 
ATOM   272  C  CA  . PRO A 1 41  ? -12.17053 55.45576 -64.06477 1.000 76.28483  ? 39  PRO A CA  1 
ATOM   273  C  C   . PRO A 1 41  ? -12.29972 54.99788 -65.50706 1.000 74.44590  ? 39  PRO A C   1 
ATOM   274  O  O   . PRO A 1 41  ? -11.54389 54.14166 -65.96843 1.000 78.48355  ? 39  PRO A O   1 
ATOM   275  C  CB  . PRO A 1 41  ? -11.01469 56.44752 -63.89151 1.000 72.18416  ? 39  PRO A CB  1 
ATOM   276  C  CG  . PRO A 1 41  ? -10.40845 56.08994 -62.56684 1.000 69.22805  ? 39  PRO A CG  1 
ATOM   277  C  CD  . PRO A 1 41  ? -10.53430 54.59994 -62.46872 1.000 71.65123  ? 39  PRO A CD  1 
ATOM   278  N  N   . GLU A 1 42  ? -13.27575 55.57072 -66.21949 1.000 72.37681  ? 40  GLU A N   1 
ATOM   279  C  CA  . GLU A 1 42  ? -13.50158 55.16843 -67.60903 1.000 83.98429  ? 40  GLU A CA  1 
ATOM   280  C  C   . GLU A 1 42  ? -12.30648 55.49355 -68.49275 1.000 77.59849  ? 40  GLU A C   1 
ATOM   281  O  O   . GLU A 1 42  ? -12.03945 54.77821 -69.46593 1.000 75.91904  ? 40  GLU A O   1 
ATOM   282  C  CB  . GLU A 1 42  ? -14.76328 55.83056 -68.15504 1.000 81.72009  ? 40  GLU A CB  1 
ATOM   283  C  CG  . GLU A 1 42  ? -15.95787 55.66167 -67.23847 1.000 83.75606  ? 40  GLU A CG  1 
ATOM   284  C  CD  . GLU A 1 42  ? -17.27504 55.75466 -67.97358 1.000 89.84243  ? 40  GLU A CD  1 
ATOM   285  O  OE1 . GLU A 1 42  ? -17.24856 55.80355 -69.22920 1.000 89.58562  ? 40  GLU A OE1 1 
ATOM   286  O  OE2 . GLU A 1 42  ? -18.32915 55.79833 -67.29051 1.000 87.47686  ? 40  GLU A OE2 1 
ATOM   287  N  N   . SER A 1 43  ? -11.56511 56.54879 -68.15758 1.000 78.95158  ? 41  SER A N   1 
ATOM   288  C  CA  . SER A 1 43  ? -10.32566 56.86607 -68.85411 1.000 83.42667  ? 41  SER A CA  1 
ATOM   289  C  C   . SER A 1 43  ? -9.28166  55.75471 -68.76148 1.000 82.57958  ? 41  SER A C   1 
ATOM   290  O  O   . SER A 1 43  ? -8.27235  55.82463 -69.47032 1.000 85.60744  ? 41  SER A O   1 
ATOM   291  C  CB  . SER A 1 43  ? -9.74656  58.16582 -68.28745 1.000 82.74260  ? 41  SER A CB  1 
ATOM   292  O  OG  . SER A 1 43  ? -9.09169  57.92758 -67.04826 1.000 86.46239  ? 41  SER A OG  1 
ATOM   293  N  N   . GLU A 1 44  ? -9.49945  54.73016 -67.92672 1.000 79.41936  ? 42  GLU A N   1 
ATOM   294  C  CA  . GLU A 1 44  ? -8.47033  53.74415 -67.60914 1.000 76.20917  ? 42  GLU A CA  1 
ATOM   295  C  C   . GLU A 1 44  ? -8.90354  52.29932 -67.82281 1.000 79.04644  ? 42  GLU A C   1 
ATOM   296  O  O   . GLU A 1 44  ? -8.21161  51.38803 -67.34509 1.000 75.56474  ? 42  GLU A O   1 
ATOM   297  C  CB  . GLU A 1 44  ? -8.02219  53.87889 -66.15430 1.000 76.91496  ? 42  GLU A CB  1 
ATOM   298  C  CG  . GLU A 1 44  ? -7.22225  55.09449 -65.81962 1.000 81.91234  ? 42  GLU A CG  1 
ATOM   299  C  CD  . GLU A 1 44  ? -6.91813  55.14033 -64.34250 1.000 86.24746  ? 42  GLU A CD  1 
ATOM   300  O  OE1 . GLU A 1 44  ? -6.83950  54.05557 -63.72137 1.000 86.45056  ? 42  GLU A OE1 1 
ATOM   301  O  OE2 . GLU A 1 44  ? -6.78312  56.25679 -63.79941 1.000 95.42787  ? 42  GLU A OE2 1 
ATOM   302  N  N   . THR A 1 45  ? -10.02799 52.05479 -68.49075 1.000 81.45760  ? 43  THR A N   1 
ATOM   303  C  CA  . THR A 1 45  ? -10.54304 50.69691 -68.63093 1.000 85.32112  ? 43  THR A CA  1 
ATOM   304  C  C   . THR A 1 45  ? -9.89698  50.01025 -69.83200 1.000 79.88640  ? 43  THR A C   1 
ATOM   305  O  O   . THR A 1 45  ? -9.85468  50.56911 -70.93368 1.000 77.21589  ? 43  THR A O   1 
ATOM   306  C  CB  . THR A 1 45  ? -12.07418 50.69469 -68.75580 1.000 79.43270  ? 43  THR A CB  1 
ATOM   307  O  OG1 . THR A 1 45  ? -12.51043 51.77825 -69.59293 1.000 81.71882  ? 43  THR A OG1 1 
ATOM   308  C  CG2 . THR A 1 45  ? -12.72134 50.82693 -67.37947 1.000 72.29168  ? 43  THR A CG2 1 
ATOM   309  N  N   . GLU A 1 46  ? -9.37269  48.80353 -69.60536 1.000 85.81002  ? 44  GLU A N   1 
ATOM   310  C  CA  . GLU A 1 46  ? -8.77966  48.04029 -70.70113 1.000 89.61114  ? 44  GLU A CA  1 
ATOM   311  C  C   . GLU A 1 46  ? -9.84921  47.54395 -71.66671 1.000 87.14780  ? 44  GLU A C   1 
ATOM   312  O  O   . GLU A 1 46  ? -9.61734  47.47610 -72.87857 1.000 85.58419  ? 44  GLU A O   1 
ATOM   313  C  CB  . GLU A 1 46  ? -7.97710  46.84953 -70.15744 1.000 89.59867  ? 44  GLU A CB  1 
ATOM   314  C  CG  . GLU A 1 46  ? -7.11650  47.10462 -68.90357 1.000 96.82571  ? 44  GLU A CG  1 
ATOM   315  C  CD  . GLU A 1 46  ? -5.79955  47.84115 -69.18529 1.000 108.11660 ? 44  GLU A CD  1 
ATOM   316  O  OE1 . GLU A 1 46  ? -5.65680  48.45839 -70.26652 1.000 111.69134 ? 44  GLU A OE1 1 
ATOM   317  O  OE2 . GLU A 1 46  ? -4.89018  47.77629 -68.32390 1.000 107.88368 ? 44  GLU A OE2 1 
ATOM   318  N  N   . HIS A 1 47  ? -11.02767 47.21023 -71.14589 1.000 79.22298  ? 45  HIS A N   1 
ATOM   319  C  CA  . HIS A 1 47  ? -12.05822 46.46484 -71.84913 1.000 62.26574  ? 45  HIS A CA  1 
ATOM   320  C  C   . HIS A 1 47  ? -13.40800 46.97360 -71.37405 1.000 54.66881  ? 45  HIS A C   1 
ATOM   321  O  O   . HIS A 1 47  ? -13.54167 47.35212 -70.20595 1.000 56.44163  ? 45  HIS A O   1 
ATOM   322  C  CB  . HIS A 1 47  ? -11.90949 44.95900 -71.57124 1.000 61.95798  ? 45  HIS A CB  1 
ATOM   323  C  CG  . HIS A 1 47  ? -12.73567 44.08492 -72.46151 1.000 68.78999  ? 45  HIS A CG  1 
ATOM   324  N  ND1 . HIS A 1 47  ? -14.11220 44.03548 -72.38691 1.000 62.26557  ? 45  HIS A ND1 1 
ATOM   325  C  CD2 . HIS A 1 47  ? -12.38009 43.21093 -73.43504 1.000 65.82271  ? 45  HIS A CD2 1 
ATOM   326  C  CE1 . HIS A 1 47  ? -14.57057 43.18252 -73.28739 1.000 65.60233  ? 45  HIS A CE1 1 
ATOM   327  N  NE2 . HIS A 1 47  ? -13.53932 42.66245 -73.93179 1.000 71.69191  ? 45  HIS A NE2 1 
ATOM   328  N  N   . PRO A 1 48  ? -14.41732 47.01568 -72.24693 1.000 59.59552  ? 46  PRO A N   1 
ATOM   329  C  CA  . PRO A 1 48  ? -15.74198 47.48685 -71.79959 1.000 56.95103  ? 46  PRO A CA  1 
ATOM   330  C  C   . PRO A 1 48  ? -16.39162 46.60030 -70.74092 1.000 60.07405  ? 46  PRO A C   1 
ATOM   331  O  O   . PRO A 1 48  ? -17.23941 47.09917 -69.99162 1.000 58.70688  ? 46  PRO A O   1 
ATOM   332  C  CB  . PRO A 1 48  ? -16.57071 47.52088 -73.09618 1.000 53.20705  ? 46  PRO A CB  1 
ATOM   333  C  CG  . PRO A 1 48  ? -15.81655 46.64797 -74.07069 1.000 58.66680  ? 46  PRO A CG  1 
ATOM   334  C  CD  . PRO A 1 48  ? -14.36922 46.79979 -73.70603 1.000 53.33236  ? 46  PRO A CD  1 
ATOM   335  N  N   . ASP A 1 49  ? -16.01405 45.32296 -70.63120 1.000 51.48091  ? 47  ASP A N   1 
ATOM   336  C  CA  . ASP A 1 49  ? -16.57647 44.43132 -69.62492 1.000 47.40479  ? 47  ASP A CA  1 
ATOM   337  C  C   . ASP A 1 49  ? -15.83838 44.49690 -68.28993 1.000 49.64637  ? 47  ASP A C   1 
ATOM   338  O  O   . ASP A 1 49  ? -16.12705 43.69940 -67.39406 1.000 45.79926  ? 47  ASP A O   1 
ATOM   339  C  CB  . ASP A 1 49  ? -16.60092 42.99250 -70.14888 1.000 45.37038  ? 47  ASP A CB  1 
ATOM   340  C  CG  . ASP A 1 49  ? -17.64297 42.79160 -71.24360 1.000 47.89579  ? 47  ASP A CG  1 
ATOM   341  O  OD1 . ASP A 1 49  ? -18.70148 43.44030 -71.16471 1.000 52.75389  ? 47  ASP A OD1 1 
ATOM   342  O  OD2 . ASP A 1 49  ? -17.40735 42.01524 -72.20143 1.000 52.75725  ? 47  ASP A OD2 1 
ATOM   343  N  N   . GLN A 1 50  ? -14.92371 45.45119 -68.12060 1.000 52.57890  ? 48  GLN A N   1 
ATOM   344  C  CA  . GLN A 1 50  ? -14.11604 45.51628 -66.90610 1.000 48.14351  ? 48  GLN A CA  1 
ATOM   345  C  C   . GLN A 1 50  ? -14.90935 46.04079 -65.71299 1.000 49.00281  ? 48  GLN A C   1 
ATOM   346  O  O   . GLN A 1 50  ? -14.76737 45.52381 -64.59766 1.000 46.74709  ? 48  GLN A O   1 
ATOM   347  C  CB  . GLN A 1 50  ? -12.89746 46.40202 -67.15538 1.000 57.85653  ? 48  GLN A CB  1 
ATOM   348  C  CG  . GLN A 1 50  ? -11.76335 46.23143 -66.15547 1.000 62.96781  ? 48  GLN A CG  1 
ATOM   349  C  CD  . GLN A 1 50  ? -10.68669 47.29456 -66.32622 1.000 74.93068  ? 48  GLN A CD  1 
ATOM   350  O  OE1 . GLN A 1 50  ? -10.26519 47.59236 -67.45040 1.000 76.16964  ? 48  GLN A OE1 1 
ATOM   351  N  NE2 . GLN A 1 50  ? -10.23388 47.86804 -65.21248 1.000 77.22964  ? 48  GLN A NE2 1 
ATOM   352  N  N   . ARG A 1 51  ? -15.69546 47.10296 -65.92535 1.000 45.20641  ? 49  ARG A N   1 
ATOM   353  C  CA  . ARG A 1 51  ? -16.58744 47.63677 -64.90004 1.000 42.87557  ? 49  ARG A CA  1 
ATOM   354  C  C   . ARG A 1 51  ? -17.49657 46.54858 -64.32167 1.000 44.16050  ? 49  ARG A C   1 
ATOM   355  O  O   . ARG A 1 51  ? -17.61187 46.39200 -63.09919 1.000 40.69764  ? 49  ARG A O   1 
ATOM   356  C  CB  . ARG A 1 51  ? -17.42334 48.76092 -65.51706 1.000 51.91040  ? 49  ARG A CB  1 
ATOM   357  C  CG  . ARG A 1 51  ? -16.76331 50.12098 -65.47644 1.000 47.90051  ? 49  ARG A CG  1 
ATOM   358  C  CD  . ARG A 1 51  ? -16.60949 50.56661 -64.03441 1.000 53.78178  ? 49  ARG A CD  1 
ATOM   359  N  NE  . ARG A 1 51  ? -16.37711 52.00011 -63.93501 1.000 65.39300  ? 49  ARG A NE  1 
ATOM   360  C  CZ  . ARG A 1 51  ? -17.29086 52.93155 -64.17794 1.000 66.25403  ? 49  ARG A CZ  1 
ATOM   361  N  NH1 . ARG A 1 51  ? -18.53608 52.61342 -64.50328 1.000 62.83144  ? 49  ARG A NH1 1 
ATOM   362  N  NH2 . ARG A 1 51  ? -16.94618 54.21493 -64.08689 1.000 64.64288  ? 49  ARG A NH2 1 
ATOM   363  N  N   . PHE A 1 52  ? -18.14585 45.78379 -65.20269 1.000 41.81398  ? 50  PHE A N   1 
ATOM   364  C  CA  . PHE A 1 52  ? -19.01973 44.69618 -64.78124 1.000 43.49473  ? 50  PHE A CA  1 
ATOM   365  C  C   . PHE A 1 52  ? -18.26621 43.71660 -63.90293 1.000 50.21685  ? 50  PHE A C   1 
ATOM   366  O  O   . PHE A 1 52  ? -18.74597 43.31662 -62.82763 1.000 46.44864  ? 50  PHE A O   1 
ATOM   367  C  CB  . PHE A 1 52  ? -19.58150 43.99284 -66.01845 1.000 42.07244  ? 50  PHE A CB  1 
ATOM   368  C  CG  . PHE A 1 52  ? -20.54700 42.87517 -65.71796 1.000 45.82827  ? 50  PHE A CG  1 
ATOM   369  C  CD1 . PHE A 1 52  ? -21.64307 43.08043 -64.89106 1.000 46.14632  ? 50  PHE A CD1 1 
ATOM   370  C  CD2 . PHE A 1 52  ? -20.38493 41.62813 -66.30016 1.000 44.35721  ? 50  PHE A CD2 1 
ATOM   371  C  CE1 . PHE A 1 52  ? -22.54369 42.06074 -64.63305 1.000 44.18151  ? 50  PHE A CE1 1 
ATOM   372  C  CE2 . PHE A 1 52  ? -21.28729 40.60452 -66.04399 1.000 47.10117  ? 50  PHE A CE2 1 
ATOM   373  C  CZ  . PHE A 1 52  ? -22.37330 40.82915 -65.21139 1.000 41.76215  ? 50  PHE A CZ  1 
ATOM   374  N  N   . PHE A 1 53  ? -17.07047 43.33119 -64.35218 1.000 42.00328  ? 51  PHE A N   1 
ATOM   375  C  CA  . PHE A 1 53  ? -16.22261 42.42710 -63.59013 1.000 44.95580  ? 51  PHE A CA  1 
ATOM   376  C  C   . PHE A 1 53  ? -15.96022 42.98341 -62.19738 1.000 43.24770  ? 51  PHE A C   1 
ATOM   377  O  O   . PHE A 1 53  ? -16.15101 42.28602 -61.19606 1.000 43.31484  ? 51  PHE A O   1 
ATOM   378  C  CB  . PHE A 1 53  ? -14.92719 42.19944 -64.38096 1.000 49.49691  ? 51  PHE A CB  1 
ATOM   379  C  CG  . PHE A 1 53  ? -13.93770 41.28457 -63.72450 1.000 44.18046  ? 51  PHE A CG  1 
ATOM   380  C  CD1 . PHE A 1 53  ? -13.94941 39.92403 -63.99250 1.000 47.12169  ? 51  PHE A CD1 1 
ATOM   381  C  CD2 . PHE A 1 53  ? -12.94457 41.79782 -62.87965 1.000 52.01274  ? 51  PHE A CD2 1 
ATOM   382  C  CE1 . PHE A 1 53  ? -13.01349 39.07294 -63.40428 1.000 46.42690  ? 51  PHE A CE1 1 
ATOM   383  C  CE2 . PHE A 1 53  ? -12.00114 40.95299 -62.28377 1.000 54.46533  ? 51  PHE A CE2 1 
ATOM   384  C  CZ  . PHE A 1 53  ? -12.04386 39.58625 -62.55066 1.000 52.80994  ? 51  PHE A CZ  1 
ATOM   385  N  N   . GLN A 1 54  ? -15.56256 44.25743 -62.11438 1.000 37.94134  ? 52  GLN A N   1 
ATOM   386  C  CA  . GLN A 1 54  ? -15.24211 44.85866 -60.82232 1.000 39.39472  ? 52  GLN A CA  1 
ATOM   387  C  C   . GLN A 1 54  ? -16.46489 44.92263 -59.91278 1.000 42.71724  ? 52  GLN A C   1 
ATOM   388  O  O   . GLN A 1 54  ? -16.38935 44.56392 -58.73238 1.000 41.75412  ? 52  GLN A O   1 
ATOM   389  C  CB  . GLN A 1 54  ? -14.66215 46.26499 -61.01504 1.000 37.37856  ? 52  GLN A CB  1 
ATOM   390  C  CG  . GLN A 1 54  ? -14.21890 46.94044 -59.69301 1.000 38.02090  ? 52  GLN A CG  1 
ATOM   391  C  CD  . GLN A 1 54  ? -13.90567 48.43898 -59.84235 1.000 46.40212  ? 52  GLN A CD  1 
ATOM   392  O  OE1 . GLN A 1 54  ? -14.19357 49.05388 -60.86959 1.000 49.15051  ? 52  GLN A OE1 1 
ATOM   393  N  NE2 . GLN A 1 54  ? -13.33199 49.02581 -58.80212 1.000 44.16787  ? 52  GLN A NE2 1 
ATOM   394  N  N   . VAL A 1 55  ? -17.60204 45.38897 -60.44627 1.000 41.63045  ? 53  VAL A N   1 
ATOM   395  C  CA  . VAL A 1 55  ? -18.77411 45.65381 -59.61292 1.000 39.71727  ? 53  VAL A CA  1 
ATOM   396  C  C   . VAL A 1 55  ? -19.32944 44.37402 -58.98848 1.000 39.07054  ? 53  VAL A C   1 
ATOM   397  O  O   . VAL A 1 55  ? -19.77099 44.39215 -57.83018 1.000 38.80281  ? 53  VAL A O   1 
ATOM   398  C  CB  . VAL A 1 55  ? -19.84476 46.40864 -60.42523 1.000 44.41875  ? 53  VAL A CB  1 
ATOM   399  C  CG1 . VAL A 1 55  ? -21.16796 46.37049 -59.72103 1.000 41.17121  ? 53  VAL A CG1 1 
ATOM   400  C  CG2 . VAL A 1 55  ? -19.41733 47.86335 -60.63433 1.000 43.72557  ? 53  VAL A CG2 1 
ATOM   401  N  N   . THR A 1 56  ? -19.29091 43.23874 -59.70113 1.000 35.03528  ? 54  THR A N   1 
ATOM   402  C  CA  . THR A 1 56  ? -19.79228 42.01373 -59.08108 1.000 37.52889  ? 54  THR A CA  1 
ATOM   403  C  C   . THR A 1 56  ? -18.91246 41.58062 -57.91793 1.000 41.62509  ? 54  THR A C   1 
ATOM   404  O  O   . THR A 1 56  ? -19.43488 41.04253 -56.92785 1.000 39.94872  ? 54  THR A O   1 
ATOM   405  C  CB  . THR A 1 56  ? -19.93444 40.86439 -60.09857 1.000 41.43351  ? 54  THR A CB  1 
ATOM   406  O  OG1 . THR A 1 56  ? -18.66406 40.54736 -60.66970 1.000 46.12586  ? 54  THR A OG1 1 
ATOM   407  C  CG2 . THR A 1 56  ? -20.88473 41.23541 -61.22104 1.000 35.77635  ? 54  THR A CG2 1 
ATOM   408  N  N   . HIS A 1 57  ? -17.58596 41.80528 -58.01064 1.000 41.58154  ? 55  HIS A N   1 
ATOM   409  C  CA  . HIS A 1 57  ? -16.69413 41.53401 -56.87469 1.000 41.03724  ? 55  HIS A CA  1 
ATOM   410  C  C   . HIS A 1 57  ? -17.00889 42.46046 -55.71593 1.000 36.15079  ? 55  HIS A C   1 
ATOM   411  O  O   . HIS A 1 57  ? -17.07755 42.02731 -54.56266 1.000 41.17610  ? 55  HIS A O   1 
ATOM   412  C  CB  . HIS A 1 57  ? -15.21708 41.71499 -57.25155 1.000 41.62390  ? 55  HIS A CB  1 
ATOM   413  C  CG  . HIS A 1 57  ? -14.63516 40.59268 -58.05178 1.000 42.60556  ? 55  HIS A CG  1 
ATOM   414  N  ND1 . HIS A 1 57  ? -14.70045 40.54774 -59.42918 1.000 41.40432  ? 55  HIS A ND1 1 
ATOM   415  C  CD2 . HIS A 1 57  ? -13.93701 39.49530 -57.67181 1.000 42.99498  ? 55  HIS A CD2 1 
ATOM   416  C  CE1 . HIS A 1 57  ? -14.09264 39.45676 -59.86210 1.000 41.95639  ? 55  HIS A CE1 1 
ATOM   417  N  NE2 . HIS A 1 57  ? -13.62138 38.80127 -58.81520 1.000 43.29002  ? 55  HIS A NE2 1 
ATOM   418  N  N   . LEU A 1 58  ? -17.17121 43.75194 -56.00457 1.000 35.91645  ? 56  LEU A N   1 
ATOM   419  C  CA  . LEU A 1 58  ? -17.39584 44.72160 -54.93708 1.000 44.57385  ? 56  LEU A CA  1 
ATOM   420  C  C   . LEU A 1 58  ? -18.70393 44.43867 -54.20205 1.000 39.47813  ? 56  LEU A C   1 
ATOM   421  O  O   . LEU A 1 58  ? -18.76437 44.49679 -52.96666 1.000 39.80346  ? 56  LEU A O   1 
ATOM   422  C  CB  . LEU A 1 58  ? -17.38802 46.13938 -55.52192 1.000 45.33762  ? 56  LEU A CB  1 
ATOM   423  C  CG  . LEU A 1 58  ? -15.99112 46.64140 -55.92837 1.000 48.13892  ? 56  LEU A CG  1 
ATOM   424  C  CD1 . LEU A 1 58  ? -16.04238 48.06834 -56.41961 1.000 43.13964  ? 56  LEU A CD1 1 
ATOM   425  C  CD2 . LEU A 1 58  ? -15.00970 46.51348 -54.77294 1.000 42.07636  ? 56  LEU A CD2 1 
ATOM   426  N  N   . ILE A 1 59  ? -19.76288 44.13904 -54.95248 1.000 40.45391  ? 57  ILE A N   1 
ATOM   427  C  CA  . ILE A 1 59  ? -21.02941 43.77721 -54.33715 1.000 41.43107  ? 57  ILE A CA  1 
ATOM   428  C  C   . ILE A 1 59  ? -20.84239 42.56523 -53.44144 1.000 39.58573  ? 57  ILE A C   1 
ATOM   429  O  O   . ILE A 1 59  ? -21.34157 42.52797 -52.30615 1.000 35.89871  ? 57  ILE A O   1 
ATOM   430  C  CB  . ILE A 1 59  ? -22.08666 43.52959 -55.42656 1.000 37.50685  ? 57  ILE A CB  1 
ATOM   431  C  CG1 . ILE A 1 59  ? -22.53956 44.86848 -56.02183 1.000 38.43191  ? 57  ILE A CG1 1 
ATOM   432  C  CG2 . ILE A 1 59  ? -23.23843 42.73999 -54.86719 1.000 34.96007  ? 57  ILE A CG2 1 
ATOM   433  C  CD1 . ILE A 1 59  ? -23.43169 44.73624 -57.30257 1.000 33.65966  ? 57  ILE A CD1 1 
ATOM   434  N  N   . THR A 1 60  ? -20.08772 41.57207 -53.92762 1.000 37.32238  ? 58  THR A N   1 
ATOM   435  C  CA  . THR A 1 60  ? -19.81887 40.37060 -53.14387 1.000 36.72000  ? 58  THR A CA  1 
ATOM   436  C  C   . THR A 1 60  ? -19.07818 40.69899 -51.86442 1.000 38.30119  ? 58  THR A C   1 
ATOM   437  O  O   . THR A 1 60  ? -19.40218 40.16326 -50.78929 1.000 38.55980  ? 58  THR A O   1 
ATOM   438  C  CB  . THR A 1 60  ? -19.01228 39.37487 -53.97151 1.000 37.13884  ? 58  THR A CB  1 
ATOM   439  O  OG1 . THR A 1 60  ? -19.79665 38.94538 -55.09534 1.000 36.81170  ? 58  THR A OG1 1 
ATOM   440  C  CG2 . THR A 1 60  ? -18.63554 38.19078 -53.13256 1.000 30.61590  ? 58  THR A CG2 1 
ATOM   441  N  N   . GLU A 1 61  ? -18.09124 41.59251 -51.95356 1.000 36.31517  ? 59  GLU A N   1 
ATOM   442  C  CA  . GLU A 1 61  ? -17.25582 41.87015 -50.79199 1.000 38.25109  ? 59  GLU A CA  1 
ATOM   443  C  C   . GLU A 1 61  ? -18.02661 42.66405 -49.74647 1.000 39.59475  ? 59  GLU A C   1 
ATOM   444  O  O   . GLU A 1 61  ? -17.84206 42.45855 -48.53869 1.000 43.51870  ? 59  GLU A O   1 
ATOM   445  C  CB  . GLU A 1 61  ? -15.97598 42.60396 -51.22979 1.000 37.57191  ? 59  GLU A CB  1 
ATOM   446  C  CG  . GLU A 1 61  ? -14.99629 41.70572 -52.03897 1.000 40.90760  ? 59  GLU A CG  1 
ATOM   447  C  CD  . GLU A 1 61  ? -14.24991 40.62850 -51.20723 1.000 44.31716  ? 59  GLU A CD  1 
ATOM   448  O  OE1 . GLU A 1 61  ? -14.20298 40.69814 -49.95090 1.000 47.37468  ? 59  GLU A OE1 1 
ATOM   449  O  OE2 . GLU A 1 61  ? -13.69189 39.69684 -51.83306 1.000 46.51782  ? 59  GLU A OE2 1 
ATOM   450  N  N   . TYR A 1 62  ? -18.89729 43.57434 -50.19079 1.000 37.66034  ? 60  TYR A N   1 
ATOM   451  C  CA  . TYR A 1 62  ? -19.76556 44.27803 -49.25376 1.000 38.69563  ? 60  TYR A CA  1 
ATOM   452  C  C   . TYR A 1 62  ? -20.67671 43.30075 -48.53570 1.000 37.24245  ? 60  TYR A C   1 
ATOM   453  O  O   . TYR A 1 62  ? -20.88272 43.39342 -47.32375 1.000 38.81100  ? 60  TYR A O   1 
ATOM   454  C  CB  . TYR A 1 62  ? -20.60116 45.31619 -49.99267 1.000 43.40959  ? 60  TYR A CB  1 
ATOM   455  C  CG  . TYR A 1 62  ? -19.95018 46.65839 -50.14484 1.000 44.44241  ? 60  TYR A CG  1 
ATOM   456  C  CD1 . TYR A 1 62  ? -19.11732 47.16425 -49.16921 1.000 50.65651  ? 60  TYR A CD1 1 
ATOM   457  C  CD2 . TYR A 1 62  ? -20.17323 47.42831 -51.26932 1.000 59.46311  ? 60  TYR A CD2 1 
ATOM   458  C  CE1 . TYR A 1 62  ? -18.52809 48.40930 -49.31048 1.000 54.27847  ? 60  TYR A CE1 1 
ATOM   459  C  CE2 . TYR A 1 62  ? -19.58730 48.66671 -51.40950 1.000 56.97621  ? 60  TYR A CE2 1 
ATOM   460  C  CZ  . TYR A 1 62  ? -18.77040 49.15362 -50.43383 1.000 48.51999  ? 60  TYR A CZ  1 
ATOM   461  O  OH  . TYR A 1 62  ? -18.20003 50.39423 -50.59196 1.000 54.92673  ? 60  TYR A OH  1 
ATOM   462  N  N   . ALA A 1 63  ? -21.21250 42.33544 -49.26229 1.000 34.41432  ? 61  ALA A N   1 
ATOM   463  C  CA  . ALA A 1 63  ? -22.05983 41.36148 -48.60449 1.000 39.06113  ? 61  ALA A CA  1 
ATOM   464  C  C   . ALA A 1 63  ? -21.26596 40.57051 -47.55968 1.000 36.94120  ? 61  ALA A C   1 
ATOM   465  O  O   . ALA A 1 63  ? -21.74867 40.35790 -46.43845 1.000 38.40340  ? 61  ALA A O   1 
ATOM   466  C  CB  . ALA A 1 63  ? -22.72187 40.45866 -49.66087 1.000 30.93419  ? 61  ALA A CB  1 
ATOM   467  N  N   . TRP A 1 64  ? -20.03073 40.15762 -47.88863 1.000 36.67743  ? 62  TRP A N   1 
ATOM   468  C  CA  . TRP A 1 64  ? -19.27623 39.29163 -46.97116 1.000 36.43671  ? 62  TRP A CA  1 
ATOM   469  C  C   . TRP A 1 64  ? -18.81047 40.05440 -45.73241 1.000 42.88786  ? 62  TRP A C   1 
ATOM   470  O  O   . TRP A 1 64  ? -18.79505 39.49780 -44.62052 1.000 39.26174  ? 62  TRP A O   1 
ATOM   471  C  CB  . TRP A 1 64  ? -18.08431 38.65637 -47.68747 1.000 34.96512  ? 62  TRP A CB  1 
ATOM   472  C  CG  . TRP A 1 64  ? -18.42360 37.40109 -48.43361 1.000 38.81668  ? 62  TRP A CG  1 
ATOM   473  C  CD1 . TRP A 1 64  ? -19.48387 36.56073 -48.19873 1.000 38.74207  ? 62  TRP A CD1 1 
ATOM   474  C  CD2 . TRP A 1 64  ? -17.70611 36.83815 -49.53834 1.000 36.39892  ? 62  TRP A CD2 1 
ATOM   475  N  NE1 . TRP A 1 64  ? -19.46515 35.51571 -49.09143 1.000 37.77269  ? 62  TRP A NE1 1 
ATOM   476  C  CE2 . TRP A 1 64  ? -18.38761 35.66239 -49.92503 1.000 38.25472  ? 62  TRP A CE2 1 
ATOM   477  C  CE3 . TRP A 1 64  ? -16.55842 37.21921 -50.24687 1.000 38.55250  ? 62  TRP A CE3 1 
ATOM   478  C  CZ2 . TRP A 1 64  ? -17.95414 34.86003 -50.98411 1.000 41.20156  ? 62  TRP A CZ2 1 
ATOM   479  C  CZ3 . TRP A 1 64  ? -16.12663 36.42342 -51.29341 1.000 36.88658  ? 62  TRP A CZ3 1 
ATOM   480  C  CH2 . TRP A 1 64  ? -16.82154 35.25415 -51.65308 1.000 41.51012  ? 62  TRP A CH2 1 
ATOM   481  N  N   . VAL A 1 65  ? -18.43645 41.33200 -45.89045 1.000 37.36965  ? 63  VAL A N   1 
ATOM   482  C  CA  . VAL A 1 65  ? -18.03311 42.08861 -44.70689 1.000 38.91802  ? 63  VAL A CA  1 
ATOM   483  C  C   . VAL A 1 65  ? -19.21625 42.24174 -43.76555 1.000 37.97264  ? 63  VAL A C   1 
ATOM   484  O  O   . VAL A 1 65  ? -19.06382 42.18729 -42.53638 1.000 43.28184  ? 63  VAL A O   1 
ATOM   485  C  CB  . VAL A 1 65  ? -17.42353 43.45399 -45.09372 1.000 44.15081  ? 63  VAL A CB  1 
ATOM   486  C  CG1 . VAL A 1 65  ? -18.41395 44.28979 -45.85687 1.000 41.23387  ? 63  VAL A CG1 1 
ATOM   487  C  CG2 . VAL A 1 65  ? -16.97644 44.20839 -43.83528 1.000 46.53645  ? 63  VAL A CG2 1 
ATOM   488  N  N   . GLN A 1 66  ? -20.42109 42.36772 -44.32251 1.000 39.90317  ? 64  GLN A N   1 
ATOM   489  C  CA  . GLN A 1 66  ? -21.61491 42.47509 -43.49783 1.000 37.29005  ? 64  GLN A CA  1 
ATOM   490  C  C   . GLN A 1 66  ? -21.96802 41.13907 -42.84324 1.000 38.22300  ? 64  GLN A C   1 
ATOM   491  O  O   . GLN A 1 66  ? -22.42572 41.11102 -41.69344 1.000 44.05487  ? 64  GLN A O   1 
ATOM   492  C  CB  . GLN A 1 66  ? -22.77169 43.01281 -44.34614 1.000 36.17740  ? 64  GLN A CB  1 
ATOM   493  C  CG  . GLN A 1 66  ? -23.95344 43.50948 -43.53486 1.000 40.65118  ? 64  GLN A CG  1 
ATOM   494  C  CD  . GLN A 1 66  ? -23.54084 44.52088 -42.48620 1.000 44.14269  ? 64  GLN A CD  1 
ATOM   495  O  OE1 . GLN A 1 66  ? -22.69665 45.38111 -42.74104 1.000 43.85427  ? 64  GLN A OE1 1 
ATOM   496  N  NE2 . GLN A 1 66  ? -24.12722 44.41774 -41.29631 1.000 42.89618  ? 64  GLN A NE2 1 
ATOM   497  N  N   . VAL A 1 67  ? -21.80107 40.02551 -43.56352 1.000 37.57411  ? 65  VAL A N   1 
ATOM   498  C  CA  . VAL A 1 67  ? -21.96022 38.70186 -42.94959 1.000 38.89365  ? 65  VAL A CA  1 
ATOM   499  C  C   . VAL A 1 67  ? -21.09169 38.59042 -41.69579 1.000 41.82741  ? 65  VAL A C   1 
ATOM   500  O  O   . VAL A 1 67  ? -21.54384 38.15978 -40.62497 1.000 37.48019  ? 65  VAL A O   1 
ATOM   501  C  CB  . VAL A 1 67  ? -21.60006 37.59324 -43.96381 1.000 40.12391  ? 65  VAL A CB  1 
ATOM   502  C  CG1 . VAL A 1 67  ? -21.32851 36.27622 -43.25645 1.000 34.31510  ? 65  VAL A CG1 1 
ATOM   503  C  CG2 . VAL A 1 67  ? -22.69159 37.39719 -45.00845 1.000 37.99474  ? 65  VAL A CG2 1 
ATOM   504  N  N   . HIS A 1 68  ? -19.81507 38.95412 -41.82918 1.000 40.55415  ? 66  HIS A N   1 
ATOM   505  C  CA  . HIS A 1 68  ? -18.88179 38.89885 -40.70500 1.000 39.45029  ? 66  HIS A CA  1 
ATOM   506  C  C   . HIS A 1 68  ? -19.38467 39.72238 -39.52535 1.000 40.23325  ? 66  HIS A C   1 
ATOM   507  O  O   . HIS A 1 68  ? -19.36972 39.26858 -38.37414 1.000 45.08476  ? 66  HIS A O   1 
ATOM   508  C  CB  . HIS A 1 68  ? -17.51864 39.40562 -41.17697 1.000 37.46835  ? 66  HIS A CB  1 
ATOM   509  C  CG  . HIS A 1 68  ? -16.44265 39.28853 -40.15884 1.000 49.12017  ? 66  HIS A CG  1 
ATOM   510  N  ND1 . HIS A 1 68  ? -16.22197 40.25450 -39.19936 1.000 57.23671  ? 66  HIS A ND1 1 
ATOM   511  C  CD2 . HIS A 1 68  ? -15.51049 38.32796 -39.95641 1.000 45.47061  ? 66  HIS A CD2 1 
ATOM   512  C  CE1 . HIS A 1 68  ? -15.19574 39.89245 -38.45140 1.000 53.92698  ? 66  HIS A CE1 1 
ATOM   513  N  NE2 . HIS A 1 68  ? -14.74639 38.72958 -38.89141 1.000 51.68297  ? 66  HIS A NE2 1 
ATOM   514  N  N   . TYR A 1 69  ? -19.82924 40.94588 -39.80036 1.000 39.20158  ? 67  TYR A N   1 
ATOM   515  C  CA  . TYR A 1 69  ? -20.35633 41.80412 -38.74971 1.000 41.73217  ? 67  TYR A CA  1 
ATOM   516  C  C   . TYR A 1 69  ? -21.54113 41.15357 -38.04632 1.000 40.87877  ? 67  TYR A C   1 
ATOM   517  O  O   . TYR A 1 69  ? -21.65574 41.22381 -36.81902 1.000 49.22638  ? 67  TYR A O   1 
ATOM   518  C  CB  . TYR A 1 69  ? -20.73693 43.14246 -39.36651 1.000 44.12179  ? 67  TYR A CB  1 
ATOM   519  C  CG  . TYR A 1 69  ? -21.14837 44.22851 -38.42287 1.000 43.86289  ? 67  TYR A CG  1 
ATOM   520  C  CD1 . TYR A 1 69  ? -22.46208 44.32431 -37.96270 1.000 44.17175  ? 67  TYR A CD1 1 
ATOM   521  C  CD2 . TYR A 1 69  ? -20.23600 45.19243 -38.02279 1.000 52.43426  ? 67  TYR A CD2 1 
ATOM   522  C  CE1 . TYR A 1 69  ? -22.84417 45.34032 -37.10312 1.000 44.26418  ? 67  TYR A CE1 1 
ATOM   523  C  CE2 . TYR A 1 69  ? -20.60266 46.21150 -37.16619 1.000 56.97725  ? 67  TYR A CE2 1 
ATOM   524  C  CZ  . TYR A 1 69  ? -21.90459 46.28454 -36.71084 1.000 53.59870  ? 67  TYR A CZ  1 
ATOM   525  O  OH  . TYR A 1 69  ? -22.24939 47.31947 -35.87609 1.000 53.97015  ? 67  TYR A OH  1 
ATOM   526  N  N   . GLU A 1 70  ? -22.42119 40.49282 -38.79748 1.000 38.25135  ? 68  GLU A N   1 
ATOM   527  C  CA  . GLU A 1 70  ? -23.55931 39.84724 -38.15594 1.000 43.61297  ? 68  GLU A CA  1 
ATOM   528  C  C   . GLU A 1 70  ? -23.14912 38.57738 -37.40952 1.000 42.74706  ? 68  GLU A C   1 
ATOM   529  O  O   . GLU A 1 70  ? -23.76816 38.23571 -36.39463 1.000 46.54924  ? 68  GLU A O   1 
ATOM   530  C  CB  . GLU A 1 70  ? -24.67235 39.54445 -39.18373 1.000 35.93233  ? 68  GLU A CB  1 
ATOM   531  C  CG  . GLU A 1 70  ? -25.18363 40.73816 -40.00809 1.000 47.47554  ? 68  GLU A CG  1 
ATOM   532  C  CD  . GLU A 1 70  ? -25.74515 41.93738 -39.18924 1.000 53.36915  ? 68  GLU A CD  1 
ATOM   533  O  OE1 . GLU A 1 70  ? -25.95775 41.81769 -37.96085 1.000 55.77922  ? 68  GLU A OE1 1 
ATOM   534  O  OE2 . GLU A 1 70  ? -25.97390 43.01809 -39.79261 1.000 44.69978  ? 68  GLU A OE2 1 
ATOM   535  N  N   . LEU A 1 71  ? -22.13775 37.84675 -37.89024 1.000 40.75915  ? 69  LEU A N   1 
ATOM   536  C  CA  . LEU A 1 71  ? -21.69714 36.67167 -37.13987 1.000 40.38877  ? 69  LEU A CA  1 
ATOM   537  C  C   . LEU A 1 71  ? -21.02525 37.07342 -35.83028 1.000 44.51691  ? 69  LEU A C   1 
ATOM   538  O  O   . LEU A 1 71  ? -21.16673 36.37992 -34.81755 1.000 42.23958  ? 69  LEU A O   1 
ATOM   539  C  CB  . LEU A 1 71  ? -20.75776 35.80844 -37.98218 1.000 36.44137  ? 69  LEU A CB  1 
ATOM   540  C  CG  . LEU A 1 71  ? -21.54252 35.14785 -39.10831 1.000 36.54616  ? 69  LEU A CG  1 
ATOM   541  C  CD1 . LEU A 1 71  ? -20.64276 34.36704 -40.02183 1.000 33.55381  ? 69  LEU A CD1 1 
ATOM   542  C  CD2 . LEU A 1 71  ? -22.60858 34.28255 -38.55351 1.000 36.89478  ? 69  LEU A CD2 1 
ATOM   543  N  N   . ARG A 1 72  ? -20.27747 38.17746 -35.82912 1.000 37.33367  ? 70  ARG A N   1 
ATOM   544  C  CA  . ARG A 1 72  ? -19.75330 38.69046 -34.56601 1.000 43.36280  ? 70  ARG A CA  1 
ATOM   545  C  C   . ARG A 1 72  ? -20.87707 38.97450 -33.58001 1.000 46.66875  ? 70  ARG A C   1 
ATOM   546  O  O   . ARG A 1 72  ? -20.75854 38.67063 -32.38932 1.000 50.87941  ? 70  ARG A O   1 
ATOM   547  C  CB  . ARG A 1 72  ? -18.94464 39.95893 -34.80051 1.000 41.24066  ? 70  ARG A CB  1 
ATOM   548  C  CG  . ARG A 1 72  ? -17.65276 39.72769 -35.51752 1.000 46.20676  ? 70  ARG A CG  1 
ATOM   549  C  CD  . ARG A 1 72  ? -16.67137 40.75669 -35.08805 1.000 59.55579  ? 70  ARG A CD  1 
ATOM   550  N  NE  . ARG A 1 72  ? -16.92666 42.02307 -35.75392 1.000 59.24407  ? 70  ARG A NE  1 
ATOM   551  C  CZ  . ARG A 1 72  ? -16.97664 43.20281 -35.15028 1.000 64.92048  ? 70  ARG A CZ  1 
ATOM   552  N  NH1 . ARG A 1 72  ? -16.86498 43.31826 -33.83331 1.000 60.49855  ? 70  ARG A NH1 1 
ATOM   553  N  NH2 . ARG A 1 72  ? -17.12372 44.29658 -35.88964 1.000 63.80814  ? 70  ARG A NH2 1 
ATOM   554  N  N   . ARG A 1 73  ? -21.97481 39.56353 -34.05406 1.000 44.06069  ? 71  ARG A N   1 
ATOM   555  C  CA  . ARG A 1 73  ? -23.09413 39.83617 -33.16228 1.000 42.89719  ? 71  ARG A CA  1 
ATOM   556  C  C   . ARG A 1 73  ? -23.69650 38.54148 -32.65806 1.000 43.34906  ? 71  ARG A C   1 
ATOM   557  O  O   . ARG A 1 73  ? -24.07688 38.44471 -31.48775 1.000 46.32769  ? 71  ARG A O   1 
ATOM   558  C  CB  . ARG A 1 73  ? -24.15116 40.68548 -33.87144 1.000 41.45146  ? 71  ARG A CB  1 
ATOM   559  C  CG  . ARG A 1 73  ? -23.69280 42.10751 -34.19187 1.000 35.38329  ? 71  ARG A CG  1 
ATOM   560  C  CD  . ARG A 1 73  ? -24.75702 42.85436 -35.00025 1.000 45.15804  ? 71  ARG A CD  1 
ATOM   561  N  NE  . ARG A 1 73  ? -26.01388 43.04063 -34.27427 1.000 45.59735  ? 71  ARG A NE  1 
ATOM   562  C  CZ  . ARG A 1 73  ? -27.11252 43.56658 -34.80781 1.000 50.16215  ? 71  ARG A CZ  1 
ATOM   563  N  NH1 . ARG A 1 73  ? -27.16519 43.90709 -36.08555 1.000 46.96453  ? 71  ARG A NH1 1 
ATOM   564  N  NH2 . ARG A 1 73  ? -28.19038 43.74452 -34.04398 1.000 42.70658  ? 71  ARG A NH2 1 
ATOM   565  N  N   . ALA A 1 74  ? -23.76534 37.52624 -33.52736 1.000 45.59529  ? 72  ALA A N   1 
ATOM   566  C  CA  . ALA A 1 74  ? -24.30190 36.22667 -33.13580 1.000 40.89834  ? 72  ALA A CA  1 
ATOM   567  C  C   . ALA A 1 74  ? -23.46711 35.59619 -32.03388 1.000 48.15783  ? 72  ALA A C   1 
ATOM   568  O  O   . ALA A 1 74  ? -24.01570 34.99721 -31.09717 1.000 47.29241  ? 72  ALA A O   1 
ATOM   569  C  CB  . ALA A 1 74  ? -24.36274 35.28914 -34.34364 1.000 41.16375  ? 72  ALA A CB  1 
ATOM   570  N  N   . ILE A 1 75  ? -22.13649 35.69239 -32.14607 1.000 42.21361  ? 73  ILE A N   1 
ATOM   571  C  CA  . ILE A 1 75  ? -21.26776 35.18577 -31.09209 1.000 41.32884  ? 73  ILE A CA  1 
ATOM   572  C  C   . ILE A 1 75  ? -21.60610 35.86297 -29.77210 1.000 46.49204  ? 73  ILE A C   1 
ATOM   573  O  O   . ILE A 1 75  ? -21.79516 35.19761 -28.74627 1.000 47.37365  ? 73  ILE A O   1 
ATOM   574  C  CB  . ILE A 1 75  ? -19.78842 35.38612 -31.46568 1.000 50.60599  ? 73  ILE A CB  1 
ATOM   575  C  CG1 . ILE A 1 75  ? -19.37568 34.39910 -32.55055 1.000 41.76870  ? 73  ILE A CG1 1 
ATOM   576  C  CG2 . ILE A 1 75  ? -18.88873 35.23496 -30.21071 1.000 41.98408  ? 73  ILE A CG2 1 
ATOM   577  C  CD1 . ILE A 1 75  ? -18.20612 34.88186 -33.37706 1.000 44.78157  ? 73  ILE A CD1 1 
ATOM   578  N  N   . GLY A 1 76  ? -21.70474 37.20096 -29.78777 1.000 46.51091  ? 74  GLY A N   1 
ATOM   579  C  CA  . GLY A 1 76  ? -22.12020 37.92930 -28.59637 1.000 38.95932  ? 74  GLY A CA  1 
ATOM   580  C  C   . GLY A 1 76  ? -23.44338 37.44332 -28.02824 1.000 48.63723  ? 74  GLY A C   1 
ATOM   581  O  O   . GLY A 1 76  ? -23.59411 37.31975 -26.81470 1.000 55.14787  ? 74  GLY A O   1 
ATOM   582  N  N   . HIS A 1 77  ? -24.41393 37.12859 -28.89333 1.000 48.79271  ? 75  HIS A N   1 
ATOM   583  C  CA  . HIS A 1 77  ? -25.72245 36.72458 -28.38376 1.000 49.22905  ? 75  HIS A CA  1 
ATOM   584  C  C   . HIS A 1 77  ? -25.67027 35.32642 -27.78722 1.000 52.15900  ? 75  HIS A C   1 
ATOM   585  O  O   . HIS A 1 77  ? -26.32006 35.05201 -26.76416 1.000 48.08420  ? 75  HIS A O   1 
ATOM   586  C  CB  . HIS A 1 77  ? -26.78580 36.77035 -29.48502 1.000 41.35027  ? 75  HIS A CB  1 
ATOM   587  C  CG  . HIS A 1 77  ? -27.17694 38.15262 -29.90901 1.000 51.45284  ? 75  HIS A CG  1 
ATOM   588  N  ND1 . HIS A 1 77  ? -27.33062 39.19510 -29.02028 1.000 52.50238  ? 75  HIS A ND1 1 
ATOM   589  C  CD2 . HIS A 1 77  ? -27.44068 38.66359 -31.13980 1.000 49.97643  ? 75  HIS A CD2 1 
ATOM   590  C  CE1 . HIS A 1 77  ? -27.67851 40.28672 -29.68278 1.000 58.75222  ? 75  HIS A CE1 1 
ATOM   591  N  NE2 . HIS A 1 77  ? -27.75385 39.99030 -30.97055 1.000 51.20753  ? 75  HIS A NE2 1 
ATOM   592  N  N   . LEU A 1 78  ? -24.92753 34.42475 -28.43558 1.000 46.15270  ? 76  LEU A N   1 
ATOM   593  C  CA  . LEU A 1 78  ? -24.82406 33.05173 -27.95716 1.000 49.88829  ? 76  LEU A CA  1 
ATOM   594  C  C   . LEU A 1 78  ? -24.09540 32.98518 -26.61784 1.000 50.82367  ? 76  LEU A C   1 
ATOM   595  O  O   . LEU A 1 78  ? -24.49576 32.23047 -25.72756 1.000 50.32961  ? 76  LEU A O   1 
ATOM   596  C  CB  . LEU A 1 78  ? -24.11115 32.18900 -28.99635 1.000 45.35258  ? 76  LEU A CB  1 
ATOM   597  C  CG  . LEU A 1 78  ? -24.96239 31.86772 -30.21840 1.000 44.48824  ? 76  LEU A CG  1 
ATOM   598  C  CD1 . LEU A 1 78  ? -24.15152 31.10209 -31.23814 1.000 40.77391  ? 76  LEU A CD1 1 
ATOM   599  C  CD2 . LEU A 1 78  ? -26.16815 31.08536 -29.79066 1.000 39.97000  ? 76  LEU A CD2 1 
ATOM   600  N  N   . ASP A 1 79  ? -23.03794 33.78322 -26.45482 1.000 48.68970  ? 77  ASP A N   1 
ATOM   601  C  CA  . ASP A 1 79  ? -22.27653 33.80796 -25.21148 1.000 52.66081  ? 77  ASP A CA  1 
ATOM   602  C  C   . ASP A 1 79  ? -23.10219 34.30726 -24.03615 1.000 58.80857  ? 77  ASP A C   1 
ATOM   603  O  O   . ASP A 1 79  ? -22.76641 34.00154 -22.88818 1.000 63.23518  ? 77  ASP A O   1 
ATOM   604  C  CB  . ASP A 1 79  ? -21.03583 34.69015 -25.39064 1.000 45.97301  ? 77  ASP A CB  1 
ATOM   605  C  CG  . ASP A 1 79  ? -19.92769 33.98224 -26.16628 1.000 54.91215  ? 77  ASP A CG  1 
ATOM   606  O  OD1 . ASP A 1 79  ? -20.01027 32.73321 -26.33763 1.000 46.88925  ? 77  ASP A OD1 1 
ATOM   607  O  OD2 . ASP A 1 79  ? -18.99105 34.68024 -26.62199 1.000 48.57297  ? 77  ASP A OD2 1 
ATOM   608  N  N   . GLU A 1 80  ? -24.17582 35.05556 -24.29718 1.000 55.82259  ? 78  GLU A N   1 
ATOM   609  C  CA  . GLU A 1 80  ? -25.04832 35.60408 -23.26844 1.000 49.63217  ? 78  GLU A CA  1 
ATOM   610  C  C   . GLU A 1 80  ? -26.38154 34.87508 -23.22392 1.000 48.25258  ? 78  GLU A C   1 
ATOM   611  O  O   . GLU A 1 80  ? -27.34726 35.38864 -22.66037 1.000 50.71567  ? 78  GLU A O   1 
ATOM   612  C  CB  . GLU A 1 80  ? -25.28425 37.08974 -23.52781 1.000 54.00113  ? 78  GLU A CB  1 
ATOM   613  C  CG  . GLU A 1 80  ? -24.21713 38.01684 -23.00196 1.000 65.09963  ? 78  GLU A CG  1 
ATOM   614  C  CD  . GLU A 1 80  ? -24.02635 37.89091 -21.50736 1.000 85.12132  ? 78  GLU A CD  1 
ATOM   615  O  OE1 . GLU A 1 80  ? -22.89872 37.53994 -21.08670 1.000 84.56972  ? 78  GLU A OE1 1 
ATOM   616  O  OE2 . GLU A 1 80  ? -25.01291 38.11883 -20.76058 1.000 83.59232  ? 78  GLU A OE2 1 
ATOM   617  N  N   . ASP A 1 81  ? -26.47063 33.71773 -23.87112 1.000 52.97312  ? 79  ASP A N   1 
ATOM   618  C  CA  . ASP A 1 81  ? -27.69353 32.90524 -23.91143 1.000 59.44462  ? 79  ASP A CA  1 
ATOM   619  C  C   . ASP A 1 81  ? -28.88199 33.63777 -24.54058 1.000 56.10070  ? 79  ASP A C   1 
ATOM   620  O  O   . ASP A 1 81  ? -30.03953 33.33520 -24.23933 1.000 59.87139  ? 79  ASP A O   1 
ATOM   621  C  CB  . ASP A 1 81  ? -28.05778 32.39870 -22.51667 1.000 58.78876  ? 79  ASP A CB  1 
ATOM   622  C  CG  . ASP A 1 81  ? -26.95474 31.54650 -21.91191 1.000 68.74129  ? 79  ASP A CG  1 
ATOM   623  O  OD1 . ASP A 1 81  ? -26.27228 30.81667 -22.68042 1.000 65.07253  ? 79  ASP A OD1 1 
ATOM   624  O  OD2 . ASP A 1 81  ? -26.76137 31.61342 -20.67603 1.000 70.25348  ? 79  ASP A OD2 1 
ATOM   625  N  N   . ARG A 1 82  ? -28.62518 34.59505 -25.43144 1.000 51.93605  ? 80  ARG A N   1 
ATOM   626  C  CA  . ARG A 1 82  ? -29.70907 35.28619 -26.13081 1.000 49.45523  ? 80  ARG A CA  1 
ATOM   627  C  C   . ARG A 1 82  ? -29.95791 34.58526 -27.46849 1.000 46.88276  ? 80  ARG A C   1 
ATOM   628  O  O   . ARG A 1 82  ? -29.60877 35.06128 -28.55244 1.000 50.23870  ? 80  ARG A O   1 
ATOM   629  C  CB  . ARG A 1 82  ? -29.37832 36.76251 -26.28592 1.000 50.49754  ? 80  ARG A CB  1 
ATOM   630  C  CG  . ARG A 1 82  ? -28.95648 37.41974 -24.97129 1.000 50.33412  ? 80  ARG A CG  1 
ATOM   631  C  CD  . ARG A 1 82  ? -28.81554 38.92603 -25.07997 1.000 44.40668  ? 80  ARG A CD  1 
ATOM   632  N  NE  . ARG A 1 82  ? -27.76975 39.30322 -26.02716 1.000 59.36166  ? 80  ARG A NE  1 
ATOM   633  C  CZ  . ARG A 1 82  ? -26.61701 39.87961 -25.70006 1.000 61.01536  ? 80  ARG A CZ  1 
ATOM   634  N  NH1 . ARG A 1 82  ? -26.30450 40.13888 -24.43517 1.000 65.07196  ? 80  ARG A NH1 1 
ATOM   635  N  NH2 . ARG A 1 82  ? -25.75730 40.21030 -26.66660 1.000 50.25130  ? 80  ARG A NH2 1 
ATOM   636  N  N   . TYR A 1 83  ? -30.58424 33.41043 -27.35468 1.000 51.68099  ? 81  TYR A N   1 
ATOM   637  C  CA  . TYR A 1 83  ? -30.71109 32.49156 -28.48170 1.000 45.87486  ? 81  TYR A CA  1 
ATOM   638  C  C   . TYR A 1 83  ? -31.62557 33.04992 -29.57099 1.000 51.73421  ? 81  TYR A C   1 
ATOM   639  O  O   . TYR A 1 83  ? -31.28877 32.97842 -30.76074 1.000 47.29233  ? 81  TYR A O   1 
ATOM   640  C  CB  . TYR A 1 83  ? -31.21959 31.13280 -27.99226 1.000 52.61241  ? 81  TYR A CB  1 
ATOM   641  C  CG  . TYR A 1 83  ? -30.41520 30.51357 -26.85418 1.000 53.33848  ? 81  TYR A CG  1 
ATOM   642  C  CD1 . TYR A 1 83  ? -29.02697 30.59459 -26.82545 1.000 58.91753  ? 81  TYR A CD1 1 
ATOM   643  C  CD2 . TYR A 1 83  ? -31.04945 29.83997 -25.81566 1.000 59.25694  ? 81  TYR A CD2 1 
ATOM   644  C  CE1 . TYR A 1 83  ? -28.29378 30.02339 -25.79517 1.000 59.63080  ? 81  TYR A CE1 1 
ATOM   645  C  CE2 . TYR A 1 83  ? -30.32428 29.27153 -24.77283 1.000 59.88484  ? 81  TYR A CE2 1 
ATOM   646  C  CZ  . TYR A 1 83  ? -28.94813 29.36825 -24.76829 1.000 64.63724  ? 81  TYR A CZ  1 
ATOM   647  O  OH  . TYR A 1 83  ? -28.22032 28.80146 -23.73605 1.000 74.11326  ? 81  TYR A OH  1 
ATOM   648  N  N   . HIS A 1 84  ? -32.79506 33.59575 -29.19464 1.000 47.90312  ? 82  HIS A N   1 
ATOM   649  C  CA  . HIS A 1 84  ? -33.68617 34.18253 -30.20223 1.000 44.48085  ? 82  HIS A CA  1 
ATOM   650  C  C   . HIS A 1 84  ? -32.97737 35.27276 -30.97870 1.000 44.07886  ? 82  HIS A C   1 
ATOM   651  O  O   . HIS A 1 84  ? -33.13530 35.38327 -32.19805 1.000 45.27257  ? 82  HIS A O   1 
ATOM   652  C  CB  . HIS A 1 84  ? -34.95415 34.76893 -29.57394 1.000 45.81582  ? 82  HIS A CB  1 
ATOM   653  C  CG  . HIS A 1 84  ? -35.80751 33.76392 -28.87005 1.000 51.25535  ? 82  HIS A CG  1 
ATOM   654  N  ND1 . HIS A 1 84  ? -35.60436 33.41364 -27.54944 1.000 50.61646  ? 82  HIS A ND1 1 
ATOM   655  C  CD2 . HIS A 1 84  ? -36.87295 33.04249 -29.29387 1.000 48.72104  ? 82  HIS A CD2 1 
ATOM   656  C  CE1 . HIS A 1 84  ? -36.50810 32.51640 -27.19215 1.000 51.59011  ? 82  HIS A CE1 1 
ATOM   657  N  NE2 . HIS A 1 84  ? -37.28860 32.27315 -28.23119 1.000 55.38817  ? 82  HIS A NE2 1 
ATOM   658  N  N   . GLN A 1 85  ? -32.16978 36.07425 -30.29631 1.000 43.02475  ? 83  GLN A N   1 
ATOM   659  C  CA  . GLN A 1 85  ? -31.49010 37.14897 -30.99433 1.000 40.92836  ? 83  GLN A CA  1 
ATOM   660  C  C   . GLN A 1 85  ? -30.42066 36.61537 -31.93427 1.000 42.67716  ? 83  GLN A C   1 
ATOM   661  O  O   . GLN A 1 85  ? -30.20962 37.18928 -33.00667 1.000 47.35149  ? 83  GLN A O   1 
ATOM   662  C  CB  . GLN A 1 85  ? -30.92137 38.13337 -29.97693 1.000 42.54491  ? 83  GLN A CB  1 
ATOM   663  C  CG  . GLN A 1 85  ? -32.02881 38.92386 -29.31087 1.000 41.17432  ? 83  GLN A CG  1 
ATOM   664  C  CD  . GLN A 1 85  ? -31.57383 39.64436 -28.06892 1.000 59.92405  ? 83  GLN A CD  1 
ATOM   665  O  OE1 . GLN A 1 85  ? -31.76523 39.15991 -26.94530 1.000 56.11341  ? 83  GLN A OE1 1 
ATOM   666  N  NE2 . GLN A 1 85  ? -30.96762 40.81070 -28.25599 1.000 57.73891  ? 83  GLN A NE2 1 
ATOM   667  N  N   . ALA A 1 86  ? -29.77753 35.49643 -31.57934 1.000 46.40066  ? 84  ALA A N   1 
ATOM   668  C  CA  . ALA A 1 86  ? -28.76781 34.90812 -32.45589 1.000 44.80349  ? 84  ALA A CA  1 
ATOM   669  C  C   . ALA A 1 86  ? -29.39017 34.39443 -33.75599 1.000 40.17448  ? 84  ALA A C   1 
ATOM   670  O  O   . ALA A 1 86  ? -28.80353 34.55167 -34.83302 1.000 43.11809  ? 84  ALA A O   1 
ATOM   671  C  CB  . ALA A 1 86  ? -28.02895 33.78412 -31.71942 1.000 42.06732  ? 84  ALA A CB  1 
ATOM   672  N  N   . VAL A 1 87  ? -30.57942 33.78618 -33.66929 1.000 39.05679  ? 85  VAL A N   1 
ATOM   673  C  CA  . VAL A 1 87  ? -31.30722 33.32483 -34.85209 1.000 43.44610  ? 85  VAL A CA  1 
ATOM   674  C  C   . VAL A 1 87  ? -31.38921 34.42263 -35.90433 1.000 42.23536  ? 85  VAL A C   1 
ATOM   675  O  O   . VAL A 1 87  ? -31.07323 34.19989 -37.07664 1.000 44.46252  ? 85  VAL A O   1 
ATOM   676  C  CB  . VAL A 1 87  ? -32.71949 32.84233 -34.47221 1.000 43.16434  ? 85  VAL A CB  1 
ATOM   677  C  CG1 . VAL A 1 87  ? -33.44974 32.38853 -35.72556 1.000 42.55610  ? 85  VAL A CG1 1 
ATOM   678  C  CG2 . VAL A 1 87  ? -32.65439 31.71876 -33.49791 1.000 49.35824  ? 85  VAL A CG2 1 
ATOM   679  N  N   . ARG A 1 88  ? -31.82911 35.62133 -35.49862 1.000 42.43109  ? 86  ARG A N   1 
ATOM   680  C  CA  . ARG A 1 88  ? -32.02562 36.71628 -36.44758 1.000 40.76815  ? 86  ARG A CA  1 
ATOM   681  C  C   . ARG A 1 88  ? -30.72057 37.06347 -37.14879 1.000 39.59978  ? 86  ARG A C   1 
ATOM   682  O  O   . ARG A 1 88  ? -30.70341 37.31811 -38.35705 1.000 45.40841  ? 86  ARG A O   1 
ATOM   683  C  CB  . ARG A 1 88  ? -32.63171 37.94149 -35.72505 1.000 35.75862  ? 86  ARG A CB  1 
ATOM   684  C  CG  . ARG A 1 88  ? -34.12079 37.73158 -35.35405 1.000 42.25949  ? 86  ARG A CG  1 
ATOM   685  C  CD  . ARG A 1 88  ? -34.88056 38.99708 -34.87657 1.000 35.59562  ? 86  ARG A CD  1 
ATOM   686  N  NE  . ARG A 1 88  ? -34.79760 39.07186 -33.42100 1.000 55.39545  ? 86  ARG A NE  1 
ATOM   687  C  CZ  . ARG A 1 88  ? -35.78212 38.82296 -32.56861 1.000 42.88864  ? 86  ARG A CZ  1 
ATOM   688  N  NH1 . ARG A 1 88  ? -37.02339 38.62911 -32.97335 1.000 43.41575  ? 86  ARG A NH1 1 
ATOM   689  N  NH2 . ARG A 1 88  ? -35.51305 38.78641 -31.26532 1.000 66.49142  ? 86  ARG A NH2 1 
ATOM   690  N  N   . MET A 1 89  ? -29.60761 37.01100 -36.41772 1.000 45.43917  ? 87  MET A N   1 
ATOM   691  C  CA  . MET A 1 89  ? -28.30331 37.30033 -37.00581 1.000 39.96491  ? 87  MET A CA  1 
ATOM   692  C  C   . MET A 1 89  ? -27.93702 36.26734 -38.06763 1.000 42.94161  ? 87  MET A C   1 
ATOM   693  O  O   . MET A 1 89  ? -27.41636 36.61976 -39.12778 1.000 40.83229  ? 87  MET A O   1 
ATOM   694  C  CB  . MET A 1 89  ? -27.24419 37.31200 -35.89941 1.000 44.26815  ? 87  MET A CB  1 
ATOM   695  C  CG  . MET A 1 89  ? -27.23240 38.54895 -35.01512 1.000 41.49762  ? 87  MET A CG  1 
ATOM   696  S  SD  . MET A 1 89  ? -27.60234 40.10652 -35.81492 1.000 65.78502  ? 87  MET A SD  1 
ATOM   697  C  CE  . MET A 1 89  ? -29.25776 40.39251 -35.19269 1.000 47.43444  ? 87  MET A CE  1 
ATOM   698  N  N   . PHE A 1 90  ? -28.18062 34.97644 -37.79202 1.000 43.67453  ? 88  PHE A N   1 
ATOM   699  C  CA  . PHE A 1 90  ? -27.82081 33.94494 -38.76260 1.000 41.94280  ? 88  PHE A CA  1 
ATOM   700  C  C   . PHE A 1 90  ? -28.70649 34.03120 -39.99379 1.000 44.49078  ? 88  PHE A C   1 
ATOM   701  O  O   . PHE A 1 90  ? -28.24068 33.78101 -41.11143 1.000 42.72475  ? 88  PHE A O   1 
ATOM   702  C  CB  . PHE A 1 90  ? -27.91366 32.54052 -38.14007 1.000 38.89551  ? 88  PHE A CB  1 
ATOM   703  C  CG  . PHE A 1 90  ? -26.75125 32.19038 -37.24547 1.000 44.58012  ? 88  PHE A CG  1 
ATOM   704  C  CD1 . PHE A 1 90  ? -25.46022 32.11749 -37.74788 1.000 46.09738  ? 88  PHE A CD1 1 
ATOM   705  C  CD2 . PHE A 1 90  ? -26.94856 31.93806 -35.89257 1.000 43.37439  ? 88  PHE A CD2 1 
ATOM   706  C  CE1 . PHE A 1 90  ? -24.38951 31.81271 -36.90653 1.000 48.93703  ? 88  PHE A CE1 1 
ATOM   707  C  CE2 . PHE A 1 90  ? -25.87659 31.63547 -35.05072 1.000 39.57610  ? 88  PHE A CE2 1 
ATOM   708  C  CZ  . PHE A 1 90  ? -24.60362 31.56960 -35.56198 1.000 41.53925  ? 88  PHE A CZ  1 
ATOM   709  N  N   . ASP A 1 91  ? -29.97551 34.39963 -39.81109 1.000 41.97448  ? 89  ASP A N   1 
ATOM   710  C  CA  . ASP A 1 91  ? -30.88035 34.52317 -40.94793 1.000 41.23037  ? 89  ASP A CA  1 
ATOM   711  C  C   . ASP A 1 91  ? -30.47244 35.70119 -41.81819 1.000 39.43715  ? 89  ASP A C   1 
ATOM   712  O  O   . ASP A 1 91  ? -30.47577 35.61038 -43.05090 1.000 36.89857  ? 89  ASP A O   1 
ATOM   713  C  CB  . ASP A 1 91  ? -32.32332 34.69097 -40.45311 1.000 39.16294  ? 89  ASP A CB  1 
ATOM   714  C  CG  . ASP A 1 91  ? -32.97455 33.34729 -40.00373 1.000 51.19443  ? 89  ASP A CG  1 
ATOM   715  O  OD1 . ASP A 1 91  ? -32.59942 32.25652 -40.51218 1.000 60.55847  ? 89  ASP A OD1 1 
ATOM   716  O  OD2 . ASP A 1 91  ? -33.89392 33.38744 -39.14481 1.000 59.23569  ? 89  ASP A OD2 1 
ATOM   717  N  N   . ARG A 1 92  ? -30.08604 36.81021 -41.18815 1.000 37.02034  ? 90  ARG A N   1 
ATOM   718  C  CA  . ARG A 1 92  ? -29.58275 37.94902 -41.94474 1.000 36.50052  ? 90  ARG A CA  1 
ATOM   719  C  C   . ARG A 1 92  ? -28.31178 37.58511 -42.71540 1.000 38.62339  ? 90  ARG A C   1 
ATOM   720  O  O   . ARG A 1 92  ? -28.18932 37.88792 -43.91122 1.000 38.02421  ? 90  ARG A O   1 
ATOM   721  C  CB  . ARG A 1 92  ? -29.33908 39.12039 -40.99872 1.000 38.01057  ? 90  ARG A CB  1 
ATOM   722  C  CG  . ARG A 1 92  ? -29.20847 40.43420 -41.70326 1.000 45.88094  ? 90  ARG A CG  1 
ATOM   723  C  CD  . ARG A 1 92  ? -28.75611 41.49831 -40.74736 1.000 50.21106  ? 90  ARG A CD  1 
ATOM   724  N  NE  . ARG A 1 92  ? -29.80952 41.85479 -39.80625 1.000 44.30301  ? 90  ARG A NE  1 
ATOM   725  C  CZ  . ARG A 1 92  ? -29.74260 42.90358 -38.99976 1.000 48.67595  ? 90  ARG A CZ  1 
ATOM   726  N  NH1 . ARG A 1 92  ? -28.66353 43.67824 -38.96098 1.000 42.01532  ? 90  ARG A NH1 1 
ATOM   727  N  NH2 . ARG A 1 92  ? -30.77909 43.18334 -38.21207 1.000 47.12662  ? 90  ARG A NH2 1 
ATOM   728  N  N   . ALA A 1 93  ? -27.37136 36.89772 -42.06046 1.000 36.16662  ? 91  ALA A N   1 
ATOM   729  C  CA  . ALA A 1 93  ? -26.18106 36.41874 -42.76101 1.000 36.72658  ? 91  ALA A CA  1 
ATOM   730  C  C   . ALA A 1 93  ? -26.54979 35.57114 -43.97346 1.000 36.67904  ? 91  ALA A C   1 
ATOM   731  O  O   . ALA A 1 93  ? -25.95278 35.71406 -45.04942 1.000 38.66264  ? 91  ALA A O   1 
ATOM   732  C  CB  . ALA A 1 93  ? -25.29867 35.62066 -41.79950 1.000 38.95235  ? 91  ALA A CB  1 
ATOM   733  N  N   . THR A 1 94  ? -27.53573 34.68593 -43.81961 1.000 34.26803  ? 92  THR A N   1 
ATOM   734  C  CA  . THR A 1 94  ? -27.94254 33.82684 -44.92676 1.000 35.60382  ? 92  THR A CA  1 
ATOM   735  C  C   . THR A 1 94  ? -28.43683 34.64334 -46.11908 1.000 40.38211  ? 92  THR A C   1 
ATOM   736  O  O   . THR A 1 94  ? -28.05871 34.37194 -47.26658 1.000 40.77395  ? 92  THR A O   1 
ATOM   737  C  CB  . THR A 1 94  ? -29.02560 32.85856 -44.46107 1.000 37.31857  ? 92  THR A CB  1 
ATOM   738  O  OG1 . THR A 1 94  ? -28.50915 32.04517 -43.40385 1.000 45.65248  ? 92  THR A OG1 1 
ATOM   739  C  CG2 . THR A 1 94  ? -29.49281 31.97781 -45.61359 1.000 31.50006  ? 92  THR A CG2 1 
ATOM   740  N  N   . GLY A 1 95  ? -29.27947 35.65044 -45.87083 1.000 36.74163  ? 93  GLY A N   1 
ATOM   741  C  CA  . GLY A 1 95  ? -29.76805 36.46427 -46.96858 1.000 28.45164  ? 93  GLY A CA  1 
ATOM   742  C  C   . GLY A 1 95  ? -28.65397 37.25392 -47.62975 1.000 37.95684  ? 93  GLY A C   1 
ATOM   743  O  O   . GLY A 1 95  ? -28.66606 37.45551 -48.84481 1.000 36.13788  ? 93  GLY A O   1 
ATOM   744  N  N   . LEU A 1 96  ? -27.67182 37.71033 -46.84281 1.000 32.59975  ? 94  LEU A N   1 
ATOM   745  C  CA  . LEU A 1 96  ? -26.51520 38.37102 -47.44415 1.000 39.11414  ? 94  LEU A CA  1 
ATOM   746  C  C   . LEU A 1 96  ? -25.70800 37.39487 -48.28865 1.000 40.35539  ? 94  LEU A C   1 
ATOM   747  O  O   . LEU A 1 96  ? -25.26054 37.72829 -49.38993 1.000 38.95576  ? 94  LEU A O   1 
ATOM   748  C  CB  . LEU A 1 96  ? -25.63502 38.98282 -46.36443 1.000 31.80266  ? 94  LEU A CB  1 
ATOM   749  C  CG  . LEU A 1 96  ? -26.28514 40.18222 -45.69085 1.000 37.34896  ? 94  LEU A CG  1 
ATOM   750  C  CD1 . LEU A 1 96  ? -25.66486 40.39504 -44.32976 1.000 36.67572  ? 94  LEU A CD1 1 
ATOM   751  C  CD2 . LEU A 1 96  ? -26.12068 41.42572 -46.58349 1.000 35.43145  ? 94  LEU A CD2 1 
ATOM   752  N  N   . SER A 1 97  ? -25.51870 36.18205 -47.78954 1.000 38.16933  ? 95  SER A N   1 
ATOM   753  C  CA  . SER A 1 97  ? -24.83955 35.17044 -48.58137 1.000 38.44414  ? 95  SER A CA  1 
ATOM   754  C  C   . SER A 1 97  ? -25.54718 34.94849 -49.92439 1.000 42.67308  ? 95  SER A C   1 
ATOM   755  O  O   . SER A 1 97  ? -24.89213 34.79094 -50.96695 1.000 39.19080  ? 95  SER A O   1 
ATOM   756  C  CB  . SER A 1 97  ? -24.75281 33.88094 -47.75827 1.000 33.25829  ? 95  SER A CB  1 
ATOM   757  O  OG  . SER A 1 97  ? -23.97738 32.92050 -48.43171 1.000 43.00540  ? 95  SER A OG  1 
ATOM   758  N  N   . GLU A 1 98  ? -26.88441 34.96704 -49.93080 1.000 38.60256  ? 96  GLU A N   1 
ATOM   759  C  CA  . GLU A 1 98  ? -27.60402 34.76014 -51.18559 1.000 36.04318  ? 96  GLU A CA  1 
ATOM   760  C  C   . GLU A 1 98  ? -27.37413 35.88588 -52.18633 1.000 42.16807  ? 96  GLU A C   1 
ATOM   761  O  O   . GLU A 1 98  ? -27.47244 35.65348 -53.39943 1.000 41.85621  ? 96  GLU A O   1 
ATOM   762  C  CB  . GLU A 1 98  ? -29.09110 34.55752 -50.90933 1.000 33.06893  ? 96  GLU A CB  1 
ATOM   763  C  CG  . GLU A 1 98  ? -29.27623 33.20618 -50.21624 1.000 44.01227  ? 96  GLU A CG  1 
ATOM   764  C  CD  . GLU A 1 98  ? -29.01580 32.02834 -51.17795 1.000 61.05067  ? 96  GLU A CD  1 
ATOM   765  O  OE1 . GLU A 1 98  ? -28.29371 31.09090 -50.76744 1.000 59.52570  ? 96  GLU A OE1 1 
ATOM   766  O  OE2 . GLU A 1 98  ? -29.54762 32.01424 -52.31836 1.000 64.06094  ? 96  GLU A OE2 1 
ATOM   767  N  N   . VAL A 1 99  ? -27.00913 37.08075 -51.72157 1.000 42.12848  ? 97  VAL A N   1 
ATOM   768  C  CA  . VAL A 1 99  ? -26.59942 38.11764 -52.66095 1.000 40.73394  ? 97  VAL A CA  1 
ATOM   769  C  C   . VAL A 1 99  ? -25.29114 37.74076 -53.35060 1.000 40.46008  ? 97  VAL A C   1 
ATOM   770  O  O   . VAL A 1 99  ? -25.11383 37.99685 -54.54840 1.000 37.04254  ? 97  VAL A O   1 
ATOM   771  C  CB  . VAL A 1 99  ? -26.49089 39.46899 -51.94607 1.000 44.05224  ? 97  VAL A CB  1 
ATOM   772  C  CG1 . VAL A 1 99  ? -25.90258 40.52103 -52.90116 1.000 43.63181  ? 97  VAL A CG1 1 
ATOM   773  C  CG2 . VAL A 1 99  ? -27.85855 39.88125 -51.46732 1.000 45.42780  ? 97  VAL A CG2 1 
ATOM   774  N  N   . THR A 1 100 ? -24.34685 37.13897 -52.61999 1.000 36.89370  ? 98  THR A N   1 
ATOM   775  C  CA  . THR A 1 100 ? -23.08957 36.75861 -53.26901 1.000 41.54995  ? 98  THR A CA  1 
ATOM   776  C  C   . THR A 1 100 ? -23.32502 35.69974 -54.33969 1.000 39.14897  ? 98  THR A C   1 
ATOM   777  O  O   . THR A 1 100 ? -22.67270 35.71460 -55.38886 1.000 41.42496  ? 98  THR A O   1 
ATOM   778  C  CB  . THR A 1 100 ? -22.05954 36.25861 -52.24868 1.000 38.24011  ? 98  THR A CB  1 
ATOM   779  O  OG1 . THR A 1 100 ? -22.45018 34.96658 -51.76122 1.000 40.06429  ? 98  THR A OG1 1 
ATOM   780  C  CG2 . THR A 1 100 ? -21.91732 37.23819 -51.08518 1.000 33.07742  ? 98  THR A CG2 1 
ATOM   781  N  N   . VAL A 1 101 ? -24.26967 34.78522 -54.10311 1.000 40.34574  ? 99  VAL A N   1 
ATOM   782  C  CA  . VAL A 1 101 ? -24.60205 33.78360 -55.11284 1.000 39.09281  ? 99  VAL A CA  1 
ATOM   783  C  C   . VAL A 1 101 ? -25.13954 34.46040 -56.36291 1.000 41.91126  ? 99  VAL A C   1 
ATOM   784  O  O   . VAL A 1 101 ? -24.73533 34.15194 -57.48827 1.000 45.23735  ? 99  VAL A O   1 
ATOM   785  C  CB  . VAL A 1 101 ? -25.60846 32.76006 -54.55390 1.000 37.80113  ? 99  VAL A CB  1 
ATOM   786  C  CG1 . VAL A 1 101 ? -25.95014 31.73369 -55.62114 1.000 40.45889  ? 99  VAL A CG1 1 
ATOM   787  C  CG2 . VAL A 1 101 ? -25.04895 32.07743 -53.35651 1.000 33.04878  ? 99  VAL A CG2 1 
ATOM   788  N  N   . GLN A 1 102 ? -26.05982 35.39596 -56.18395 1.000 42.68201  ? 100 GLN A N   1 
ATOM   789  C  CA  A GLN A 1 102 ? -26.61534 36.12938 -57.31777 0.550 41.93687  ? 100 GLN A CA  1 
ATOM   790  C  CA  B GLN A 1 102 ? -26.60126 36.07683 -57.34626 0.450 41.84758  ? 100 GLN A CA  1 
ATOM   791  C  C   . GLN A 1 102 ? -25.53193 36.88974 -58.06049 1.000 41.05729  ? 100 GLN A C   1 
ATOM   792  O  O   . GLN A 1 102 ? -25.58914 37.02872 -59.28929 1.000 44.56854  ? 100 GLN A O   1 
ATOM   793  C  CB  A GLN A 1 102 ? -27.70872 37.09677 -56.83615 0.550 40.29941  ? 100 GLN A CB  1 
ATOM   794  C  CB  B GLN A 1 102 ? -27.79248 36.93413 -56.92101 0.450 40.54490  ? 100 GLN A CB  1 
ATOM   795  C  CG  A GLN A 1 102 ? -29.04306 36.98250 -57.58598 0.550 48.39526  ? 100 GLN A CG  1 
ATOM   796  C  CG  B GLN A 1 102 ? -29.01823 36.07857 -56.60090 0.450 42.10691  ? 100 GLN A CG  1 
ATOM   797  C  CD  A GLN A 1 102 ? -29.95415 38.20820 -57.41649 0.550 48.36198  ? 100 GLN A CD  1 
ATOM   798  C  CD  B GLN A 1 102 ? -29.18125 34.91466 -57.57713 0.450 46.65153  ? 100 GLN A CD  1 
ATOM   799  O  OE1 A GLN A 1 102 ? -29.82171 38.97154 -56.46189 0.550 43.26575  ? 100 GLN A OE1 1 
ATOM   800  O  OE1 B GLN A 1 102 ? -29.55431 35.11424 -58.73883 0.450 52.30930  ? 100 GLN A OE1 1 
ATOM   801  N  NE2 A GLN A 1 102 ? -30.88325 38.38496 -58.34085 0.550 42.28469  ? 100 GLN A NE2 1 
ATOM   802  N  NE2 B GLN A 1 102 ? -28.89467 33.69782 -57.11487 0.450 42.58064  ? 100 GLN A NE2 1 
ATOM   803  N  N   . ALA A 1 103 ? -24.53418 37.38993 -57.32837 1.000 36.54778  ? 101 ALA A N   1 
ATOM   804  C  CA  . ALA A 1 103 ? -23.47241 38.17147 -57.95489 1.000 35.02539  ? 101 ALA A CA  1 
ATOM   805  C  C   . ALA A 1 103 ? -22.56436 37.29840 -58.81050 1.000 43.30742  ? 101 ALA A C   1 
ATOM   806  O  O   . ALA A 1 103 ? -22.08934 37.73980 -59.85817 1.000 44.70873  ? 101 ALA A O   1 
ATOM   807  C  CB  . ALA A 1 103 ? -22.64456 38.89829 -56.89338 1.000 35.83332  ? 101 ALA A CB  1 
ATOM   808  N  N   . VAL A 1 104 ? -22.28041 36.06940 -58.37437 1.000 41.73507  ? 102 VAL A N   1 
ATOM   809  C  CA  . VAL A 1 104 ? -21.37061 35.25773 -59.17192 1.000 41.43998  ? 102 VAL A CA  1 
ATOM   810  C  C   . VAL A 1 104 ? -22.11186 34.62950 -60.34615 1.000 45.16405  ? 102 VAL A C   1 
ATOM   811  O  O   . VAL A 1 104 ? -21.53760 34.46820 -61.43576 1.000 38.30383  ? 102 VAL A O   1 
ATOM   812  C  CB  . VAL A 1 104 ? -20.64327 34.21005 -58.30039 1.000 46.05600  ? 102 VAL A CB  1 
ATOM   813  C  CG1 . VAL A 1 104 ? -21.56025 33.06052 -57.85335 1.000 36.67707  ? 102 VAL A CG1 1 
ATOM   814  C  CG2 . VAL A 1 104 ? -19.41916 33.68875 -59.03592 1.000 42.98316  ? 102 VAL A CG2 1 
ATOM   815  N  N   . ARG A 1 105 ? -23.39805 34.31271 -60.17495 1.000 37.33608  ? 103 ARG A N   1 
ATOM   816  C  CA  . ARG A 1 105 ? -24.17427 33.84781 -61.31656 1.000 42.32280  ? 103 ARG A CA  1 
ATOM   817  C  C   . ARG A 1 105 ? -24.33612 34.93610 -62.36754 1.000 44.12527  ? 103 ARG A C   1 
ATOM   818  O  O   . ARG A 1 105 ? -24.50064 34.62843 -63.54861 1.000 44.24516  ? 103 ARG A O   1 
ATOM   819  C  CB  . ARG A 1 105 ? -25.52238 33.34266 -60.85327 1.000 40.63218  ? 103 ARG A CB  1 
ATOM   820  C  CG  . ARG A 1 105 ? -25.35893 32.27420 -59.82978 1.000 49.69539  ? 103 ARG A CG  1 
ATOM   821  C  CD  . ARG A 1 105 ? -26.69032 31.75859 -59.41561 1.000 52.79001  ? 103 ARG A CD  1 
ATOM   822  N  NE  . ARG A 1 105 ? -27.16903 30.82780 -60.41600 1.000 67.10585  ? 103 ARG A NE  1 
ATOM   823  C  CZ  . ARG A 1 105 ? -28.44268 30.65931 -60.72382 1.000 72.63058  ? 103 ARG A CZ  1 
ATOM   824  N  NH1 . ARG A 1 105 ? -29.39646 31.32396 -60.08471 1.000 74.20830  ? 103 ARG A NH1 1 
ATOM   825  N  NH2 . ARG A 1 105 ? -28.76291 29.80910 -61.69979 1.000 59.69798  ? 103 ARG A NH2 1 
ATOM   826  N  N   . LEU A 1 106 ? -24.26928 36.20452 -61.96888 1.000 42.60112  ? 104 LEU A N   1 
ATOM   827  C  CA  . LEU A 1 106 ? -24.27030 37.27457 -62.95923 1.000 41.12832  ? 104 LEU A CA  1 
ATOM   828  C  C   . LEU A 1 106 ? -23.12268 37.10334 -63.93829 1.000 45.20977  ? 104 LEU A C   1 
ATOM   829  O  O   . LEU A 1 106 ? -23.30692 37.24795 -65.15098 1.000 51.22155  ? 104 LEU A O   1 
ATOM   830  C  CB  . LEU A 1 106 ? -24.17842 38.63070 -62.26220 1.000 46.54520  ? 104 LEU A CB  1 
ATOM   831  C  CG  . LEU A 1 106 ? -25.50262 39.34641 -61.99788 1.000 42.11235  ? 104 LEU A CG  1 
ATOM   832  C  CD1 . LEU A 1 106 ? -25.21355 40.65469 -61.35567 1.000 42.39562  ? 104 LEU A CD1 1 
ATOM   833  C  CD2 . LEU A 1 106 ? -26.22664 39.58004 -63.30230 1.000 48.26513  ? 104 LEU A CD2 1 
ATOM   834  N  N   . LEU A 1 107 ? -21.93025 36.77529 -63.43249 1.000 45.95426  ? 105 LEU A N   1 
ATOM   835  C  CA  . LEU A 1 107 ? -20.79700 36.53412 -64.31648 1.000 40.44822  ? 105 LEU A CA  1 
ATOM   836  C  C   . LEU A 1 107 ? -21.00891 35.28578 -65.16604 1.000 45.01002  ? 105 LEU A C   1 
ATOM   837  O  O   . LEU A 1 107 ? -20.68016 35.27893 -66.35762 1.000 45.69197  ? 105 LEU A O   1 
ATOM   838  C  CB  . LEU A 1 107 ? -19.51766 36.41114 -63.49382 1.000 44.22780  ? 105 LEU A CB  1 
ATOM   839  C  CG  . LEU A 1 107 ? -19.03777 37.70456 -62.84333 1.000 46.76459  ? 105 LEU A CG  1 
ATOM   840  C  CD1 . LEU A 1 107 ? -17.62223 37.53209 -62.42032 1.000 44.78798  ? 105 LEU A CD1 1 
ATOM   841  C  CD2 . LEU A 1 107 ? -19.14511 38.85615 -63.82733 1.000 42.53123  ? 105 LEU A CD2 1 
ATOM   842  N  N   . THR A 1 108 ? -21.54342 34.21425 -64.57486 1.000 39.62394  ? 106 THR A N   1 
ATOM   843  C  CA  . THR A 1 108 ? -21.79545 33.00650 -65.35296 1.000 39.81238  ? 106 THR A CA  1 
ATOM   844  C  C   . THR A 1 108 ? -22.71662 33.28748 -66.53309 1.000 46.28457  ? 106 THR A C   1 
ATOM   845  O  O   . THR A 1 108 ? -22.53095 32.73323 -67.62046 1.000 58.25396  ? 106 THR A O   1 
ATOM   846  C  CB  . THR A 1 108 ? -22.42360 31.93267 -64.47420 1.000 44.18723  ? 106 THR A CB  1 
ATOM   847  O  OG1 . THR A 1 108 ? -21.63140 31.74892 -63.30755 1.000 48.54615  ? 106 THR A OG1 1 
ATOM   848  C  CG2 . THR A 1 108 ? -22.52119 30.63256 -65.22582 1.000 45.12013  ? 106 THR A CG2 1 
ATOM   849  N  N   . ASP A 1 109 ? -23.71912 34.14288 -66.33873 1.000 45.56402  ? 107 ASP A N   1 
ATOM   850  C  CA  . ASP A 1 109 ? -24.75329 34.33920 -67.34685 1.000 48.34708  ? 107 ASP A CA  1 
ATOM   851  C  C   . ASP A 1 109 ? -24.41722 35.42802 -68.35140 1.000 44.31011  ? 107 ASP A C   1 
ATOM   852  O  O   . ASP A 1 109 ? -24.90838 35.37302 -69.47932 1.000 49.63480  ? 107 ASP A O   1 
ATOM   853  C  CB  . ASP A 1 109 ? -26.09736 34.65968 -66.67258 1.000 45.24068  ? 107 ASP A CB  1 
ATOM   854  C  CG  . ASP A 1 109 ? -26.68882 33.45107 -65.97661 1.000 53.79124  ? 107 ASP A CG  1 
ATOM   855  O  OD1 . ASP A 1 109 ? -26.27798 32.32724 -66.32354 1.000 58.28122  ? 107 ASP A OD1 1 
ATOM   856  O  OD2 . ASP A 1 109 ? -27.54233 33.60274 -65.07333 1.000 61.86576  ? 107 ASP A OD2 1 
ATOM   857  N  N   . HIS A 1 110 ? -23.58736 36.40697 -67.98482 1.000 42.42409  ? 108 HIS A N   1 
ATOM   858  C  CA  . HIS A 1 110 ? -23.38415 37.56904 -68.83286 1.000 45.22626  ? 108 HIS A CA  1 
ATOM   859  C  C   . HIS A 1 110 ? -21.93256 37.89997 -69.13790 1.000 46.11276  ? 108 HIS A C   1 
ATOM   860  O  O   . HIS A 1 110 ? -21.69238 38.72362 -70.02222 1.000 50.42447  ? 108 HIS A O   1 
ATOM   861  C  CB  . HIS A 1 110 ? -24.05902 38.80636 -68.20949 1.000 41.48394  ? 108 HIS A CB  1 
ATOM   862  C  CG  . HIS A 1 110 ? -25.50047 38.58329 -67.88126 1.000 48.67214  ? 108 HIS A CG  1 
ATOM   863  N  ND1 . HIS A 1 110 ? -26.46898 38.44159 -68.85164 1.000 50.04855  ? 108 HIS A ND1 1 
ATOM   864  C  CD2 . HIS A 1 110 ? -26.13417 38.43025 -66.69073 1.000 50.75105  ? 108 HIS A CD2 1 
ATOM   865  C  CE1 . HIS A 1 110 ? -27.63785 38.21781 -68.27532 1.000 46.83923  ? 108 HIS A CE1 1 
ATOM   866  N  NE2 . HIS A 1 110 ? -27.46376 38.21103 -66.96437 1.000 49.14654  ? 108 HIS A NE2 1 
ATOM   867  N  N   . LEU A 1 111 ? -20.96784 37.31128 -68.45211 1.000 48.51526  ? 109 LEU A N   1 
ATOM   868  C  CA  . LEU A 1 111 ? -19.58440 37.63033 -68.78547 1.000 46.03446  ? 109 LEU A CA  1 
ATOM   869  C  C   . LEU A 1 111 ? -19.12456 36.73555 -69.92612 1.000 48.12467  ? 109 LEU A C   1 
ATOM   870  O  O   . LEU A 1 111 ? -19.03177 35.51323 -69.74498 1.000 47.98028  ? 109 LEU A O   1 
ATOM   871  C  CB  . LEU A 1 111 ? -18.66133 37.45719 -67.58297 1.000 43.13742  ? 109 LEU A CB  1 
ATOM   872  C  CG  . LEU A 1 111 ? -17.18573 37.78372 -67.83166 1.000 53.54086  ? 109 LEU A CG  1 
ATOM   873  C  CD1 . LEU A 1 111 ? -16.96691 39.28062 -67.96936 1.000 46.81818  ? 109 LEU A CD1 1 
ATOM   874  C  CD2 . LEU A 1 111 ? -16.29421 37.20472 -66.73380 1.000 43.67874  ? 109 LEU A CD2 1 
ATOM   875  N  N   . PRO A 1 112 ? -18.82550 37.30388 -71.09948 1.000 47.07365  ? 110 PRO A N   1 
ATOM   876  C  CA  . PRO A 1 112 ? -18.32578 36.48857 -72.22371 1.000 47.77216  ? 110 PRO A CA  1 
ATOM   877  C  C   . PRO A 1 112 ? -16.95894 35.89286 -71.91478 1.000 53.90791  ? 110 PRO A C   1 
ATOM   878  O  O   . PRO A 1 112 ? -16.04756 36.59018 -71.45348 1.000 54.57720  ? 110 PRO A O   1 
ATOM   879  C  CB  . PRO A 1 112 ? -18.25046 37.48706 -73.38711 1.000 46.19745  ? 110 PRO A CB  1 
ATOM   880  C  CG  . PRO A 1 112 ? -19.09675 38.68445 -72.94450 1.000 43.08409  ? 110 PRO A CG  1 
ATOM   881  C  CD  . PRO A 1 112 ? -18.93570 38.73015 -71.45585 1.000 45.61108  ? 110 PRO A CD  1 
ATOM   882  N  N   . GLN A 1 113 ? -16.82338 34.58733 -72.16603 1.000 47.35172  ? 111 GLN A N   1 
ATOM   883  C  CA  . GLN A 1 113 ? -15.53348 33.93991 -71.96254 1.000 51.69112  ? 111 GLN A CA  1 
ATOM   884  C  C   . GLN A 1 113 ? -14.42543 34.65765 -72.72734 1.000 52.03601  ? 111 GLN A C   1 
ATOM   885  O  O   . GLN A 1 113 ? -13.32014 34.85329 -72.20586 1.000 53.00762  ? 111 GLN A O   1 
ATOM   886  C  CB  . GLN A 1 113 ? -15.59769 32.47812 -72.38731 1.000 51.63702  ? 111 GLN A CB  1 
ATOM   887  C  CG  . GLN A 1 113 ? -14.22869 31.89044 -72.50593 1.000 58.24565  ? 111 GLN A CG  1 
ATOM   888  C  CD  . GLN A 1 113 ? -14.25060 30.42777 -72.80900 1.000 61.23118  ? 111 GLN A CD  1 
ATOM   889  O  OE1 . GLN A 1 113 ? -15.02740 29.97081 -73.65660 1.000 57.38944  ? 111 GLN A OE1 1 
ATOM   890  N  NE2 . GLN A 1 113 ? -13.38473 29.66956 -72.12726 1.000 51.05006  ? 111 GLN A NE2 1 
ATOM   891  N  N   . HIS A 1 114 ? -14.71970 35.10037 -73.94831 1.000 44.89612  ? 112 HIS A N   1 
ATOM   892  C  CA  . HIS A 1 114 ? -13.70317 35.77398 -74.74643 1.000 55.13328  ? 112 HIS A CA  1 
ATOM   893  C  C   . HIS A 1 114 ? -13.26539 37.10401 -74.13285 1.000 56.20016  ? 112 HIS A C   1 
ATOM   894  O  O   . HIS A 1 114 ? -12.09793 37.48306 -74.27136 1.000 60.35893  ? 112 HIS A O   1 
ATOM   895  C  CB  . HIS A 1 114 ? -14.21064 35.96429 -76.17903 1.000 55.20853  ? 112 HIS A CB  1 
ATOM   896  C  CG  . HIS A 1 114 ? -13.14135 36.35656 -77.14660 1.000 64.94976  ? 112 HIS A CG  1 
ATOM   897  N  ND1 . HIS A 1 114 ? -12.60027 37.62567 -77.17916 1.000 61.54618  ? 112 HIS A ND1 1 
ATOM   898  C  CD2 . HIS A 1 114 ? -12.50974 35.65040 -78.11554 1.000 62.72486  ? 112 HIS A CD2 1 
ATOM   899  C  CE1 . HIS A 1 114 ? -11.67897 37.68284 -78.12390 1.000 63.08613  ? 112 HIS A CE1 1 
ATOM   900  N  NE2 . HIS A 1 114 ? -11.60843 36.49969 -78.70961 1.000 68.55572  ? 112 HIS A NE2 1 
ATOM   901  N  N   . SER A 1 115 ? -14.16157 37.83323 -73.45444 1.000 58.58263  ? 113 SER A N   1 
ATOM   902  C  CA  . SER A 1 115 ? -13.70740 39.04701 -72.77230 1.000 59.05096  ? 113 SER A CA  1 
ATOM   903  C  C   . SER A 1 115 ? -12.91793 38.70596 -71.52537 1.000 57.47901  ? 113 SER A C   1 
ATOM   904  O  O   . SER A 1 115 ? -11.99941 39.44287 -71.15089 1.000 56.64471  ? 113 SER A O   1 
ATOM   905  C  CB  . SER A 1 115 ? -14.87359 39.95463 -72.37159 1.000 50.71263  ? 113 SER A CB  1 
ATOM   906  O  OG  . SER A 1 115 ? -15.87993 39.97564 -73.34730 1.000 60.33357  ? 113 SER A OG  1 
ATOM   907  N  N   . LEU A 1 116 ? -13.28591 37.62103 -70.84824 1.000 54.36339  ? 114 LEU A N   1 
ATOM   908  C  CA  . LEU A 1 116 ? -12.55213 37.25014 -69.64936 1.000 60.40978  ? 114 LEU A CA  1 
ATOM   909  C  C   . LEU A 1 116 ? -11.12400 36.85371 -70.00227 1.000 59.74433  ? 114 LEU A C   1 
ATOM   910  O  O   . LEU A 1 116 ? -10.17934 37.25181 -69.31155 1.000 57.76581  ? 114 LEU A O   1 
ATOM   911  C  CB  . LEU A 1 116 ? -13.29260 36.13430 -68.90993 1.000 53.78112  ? 114 LEU A CB  1 
ATOM   912  C  CG  . LEU A 1 116 ? -12.75493 35.56041 -67.59718 1.000 61.14310  ? 114 LEU A CG  1 
ATOM   913  C  CD1 . LEU A 1 116 ? -11.79646 34.38111 -67.84587 1.000 54.59599  ? 114 LEU A CD1 1 
ATOM   914  C  CD2 . LEU A 1 116 ? -12.10315 36.66106 -66.73389 1.000 53.92633  ? 114 LEU A CD2 1 
ATOM   915  N  N   . LEU A 1 117 ? -10.93979 36.12667 -71.11125 1.000 60.53663  ? 115 LEU A N   1 
ATOM   916  C  CA  . LEU A 1 117 ? -9.59085  35.71329 -71.50074 1.000 56.60114  ? 115 LEU A CA  1 
ATOM   917  C  C   . LEU A 1 117 ? -8.73623  36.91122 -71.91502 1.000 63.70859  ? 115 LEU A C   1 
ATOM   918  O  O   . LEU A 1 117 ? -7.57161  37.00856 -71.51035 1.000 67.07397  ? 115 LEU A O   1 
ATOM   919  C  CB  . LEU A 1 117 ? -9.65893  34.66410 -72.60919 1.000 53.98836  ? 115 LEU A CB  1 
ATOM   920  C  CG  . LEU A 1 117 ? -10.40299 33.36627 -72.25866 1.000 54.33595  ? 115 LEU A CG  1 
ATOM   921  C  CD1 . LEU A 1 117 ? -10.37850 32.38132 -73.41246 1.000 64.60299  ? 115 LEU A CD1 1 
ATOM   922  C  CD2 . LEU A 1 117 ? -9.86551  32.71192 -70.99993 1.000 51.99532  ? 115 LEU A CD2 1 
ATOM   923  N  N   . MET A 1 118 ? -9.30194  37.85351 -72.68287 1.000 54.87705  ? 116 MET A N   1 
ATOM   924  C  CA  . MET A 1 118 ? -8.56388  39.07118 -73.01362 1.000 55.88619  ? 116 MET A CA  1 
ATOM   925  C  C   . MET A 1 118 ? -8.28196  39.89976 -71.77319 1.000 63.33298  ? 116 MET A C   1 
ATOM   926  O  O   . MET A 1 118 ? -7.22542  40.53111 -71.66558 1.000 69.80931  ? 116 MET A O   1 
ATOM   927  C  CB  . MET A 1 118 ? -9.32340  39.93062 -74.03059 1.000 56.77863  ? 116 MET A CB  1 
ATOM   928  C  CG  . MET A 1 118 ? -9.77682  39.19117 -75.26464 1.000 66.09409  ? 116 MET A CG  1 
ATOM   929  S  SD  . MET A 1 118 ? -8.39898  38.70619 -76.34098 1.000 78.26870  ? 116 MET A SD  1 
ATOM   930  C  CE  . MET A 1 118 ? -8.17813  36.96971 -75.89246 1.000 64.56575  ? 116 MET A CE  1 
ATOM   931  N  N   . MET A 1 119 ? -9.22492  39.93629 -70.83620 1.000 62.12045  ? 117 MET A N   1 
ATOM   932  C  CA  . MET A 1 119 ? -9.01373  40.72704 -69.63164 1.000 62.43684  ? 117 MET A CA  1 
ATOM   933  C  C   . MET A 1 119 ? -7.98127  40.06128 -68.73198 1.000 65.24119  ? 117 MET A C   1 
ATOM   934  O  O   . MET A 1 119 ? -7.13252  40.74110 -68.14018 1.000 66.25332  ? 117 MET A O   1 
ATOM   935  C  CB  . MET A 1 119 ? -10.34544 40.91390 -68.90008 1.000 65.29552  ? 117 MET A CB  1 
ATOM   936  C  CG  . MET A 1 119 ? -11.05558 42.20944 -69.24176 1.000 67.89380  ? 117 MET A CG  1 
ATOM   937  S  SD  . MET A 1 119 ? -12.63886 42.41819 -68.38335 1.000 71.34383  ? 117 MET A SD  1 
ATOM   938  C  CE  . MET A 1 119 ? -13.27164 40.75552 -68.34741 1.000 58.70273  ? 117 MET A CE  1 
ATOM   939  N  N   . ARG A 1 120 ? -8.03538  38.72603 -68.63098 1.000 64.33282  ? 118 ARG A N   1 
ATOM   940  C  CA  . ARG A 1 120 ? -7.06304  37.97326 -67.84490 1.000 64.16938  ? 118 ARG A CA  1 
ATOM   941  C  C   . ARG A 1 120 ? -5.63933  38.18527 -68.33800 1.000 70.59168  ? 118 ARG A C   1 
ATOM   942  O  O   . ARG A 1 120 ? -4.69826  38.03401 -67.55207 1.000 73.42867  ? 118 ARG A O   1 
ATOM   943  C  CB  . ARG A 1 120 ? -7.39829  36.47890 -67.86517 1.000 61.21036  ? 118 ARG A CB  1 
ATOM   944  C  CG  . ARG A 1 120 ? -7.16602  35.77851 -66.53631 1.000 69.44456  ? 118 ARG A CG  1 
ATOM   945  C  CD  . ARG A 1 120 ? -7.78224  34.38459 -66.49894 1.000 67.01608  ? 118 ARG A CD  1 
ATOM   946  N  NE  . ARG A 1 120 ? -6.83683  33.37290 -66.95392 1.000 72.94463  ? 118 ARG A NE  1 
ATOM   947  C  CZ  . ARG A 1 120 ? -6.18141  32.54558 -66.14983 1.000 76.13275  ? 118 ARG A CZ  1 
ATOM   948  N  NH1 . ARG A 1 120 ? -6.35677  32.57347 -64.83595 1.000 77.00901  ? 118 ARG A NH1 1 
ATOM   949  N  NH2 . ARG A 1 120 ? -5.32949  31.66746 -66.67606 1.000 78.78665  ? 118 ARG A NH2 1 
ATOM   950  N  N   . ASN A 1 121 ? -5.46286  38.55105 -69.61243 1.000 72.53451  ? 119 ASN A N   1 
ATOM   951  C  CA  . ASN A 1 121 ? -4.13078  38.83534 -70.13426 1.000 72.61186  ? 119 ASN A CA  1 
ATOM   952  C  C   . ASN A 1 121 ? -3.62219  40.19383 -69.65508 1.000 72.03084  ? 119 ASN A C   1 
ATOM   953  O  O   . ASN A 1 121 ? -2.45974  40.31346 -69.25676 1.000 80.76647  ? 119 ASN A O   1 
ATOM   954  C  CB  . ASN A 1 121 ? -4.14809  38.77089 -71.66316 1.000 73.72611  ? 119 ASN A CB  1 
ATOM   955  C  CG  . ASN A 1 121 ? -4.28077  37.33655 -72.20337 1.000 76.83200  ? 119 ASN A CG  1 
ATOM   956  O  OD1 . ASN A 1 121 ? -4.29662  36.35443 -71.44947 1.000 73.60045  ? 119 ASN A OD1 1 
ATOM   957  N  ND2 . ASN A 1 121 ? -4.41120  37.22374 -73.52462 1.000 85.07971  ? 119 ASN A ND2 1 
ATOM   958  N  N   . ALA A 1 122 ? -4.47639  41.22133 -69.66673 1.000 65.08853  ? 120 ALA A N   1 
ATOM   959  C  CA  . ALA A 1 122 ? -4.09630  42.55832 -69.22405 1.000 63.44835  ? 120 ALA A CA  1 
ATOM   960  C  C   . ALA A 1 122 ? -4.01420  42.69114 -67.70981 1.000 68.91791  ? 120 ALA A C   1 
ATOM   961  O  O   . ALA A 1 122 ? -3.72572  43.78383 -67.21068 1.000 75.85567  ? 120 ALA A O   1 
ATOM   962  C  CB  . ALA A 1 122 ? -5.09078  43.59012 -69.75579 1.000 67.81457  ? 120 ALA A CB  1 
ATOM   963  N  N   . LEU A 1 123 ? -4.26482  41.63066 -66.97884 1.000 73.97689  ? 121 LEU A N   1 
ATOM   964  C  CA  . LEU A 1 123 ? -4.44247  41.64371 -65.54052 1.000 67.42319  ? 121 LEU A CA  1 
ATOM   965  C  C   . LEU A 1 123 ? -3.22426  41.05518 -64.84382 1.000 66.86832  ? 121 LEU A C   1 
ATOM   966  O  O   . LEU A 1 123 ? -2.57581  40.15171 -65.38151 1.000 71.79298  ? 121 LEU A O   1 
ATOM   967  C  CB  . LEU A 1 123 ? -5.67973  40.82704 -65.15628 1.000 69.03424  ? 121 LEU A CB  1 
ATOM   968  C  CG  . LEU A 1 123 ? -6.70163  41.47861 -64.23556 1.000 75.52171  ? 121 LEU A CG  1 
ATOM   969  C  CD1 . LEU A 1 123 ? -7.11663  42.85137 -64.76277 1.000 66.76883  ? 121 LEU A CD1 1 
ATOM   970  C  CD2 . LEU A 1 123 ? -7.89644  40.54312 -64.09858 1.000 74.12325  ? 121 LEU A CD2 1 
ATOM   971  N  N   . PRO A 1 124 ? -2.88106  41.55209 -63.65195 1.000 61.64693  ? 122 PRO A N   1 
ATOM   972  C  CA  . PRO A 1 124 ? -1.74324  40.98386 -62.91236 1.000 59.07252  ? 122 PRO A CA  1 
ATOM   973  C  C   . PRO A 1 124 ? -1.86805  39.48204 -62.72405 1.000 61.90130  ? 122 PRO A C   1 
ATOM   974  O  O   . PRO A 1 124 ? -2.81280  38.99516 -62.09532 1.000 62.43092  ? 122 PRO A O   1 
ATOM   975  C  CB  . PRO A 1 124 ? -1.78868  41.72484 -61.57459 1.000 54.66019  ? 122 PRO A CB  1 
ATOM   976  C  CG  . PRO A 1 124 ? -2.42683  43.04252 -61.91177 1.000 60.90134  ? 122 PRO A CG  1 
ATOM   977  C  CD  . PRO A 1 124 ? -3.40485  42.77821 -63.02761 1.000 59.56177  ? 122 PRO A CD  1 
ATOM   978  N  N   . GLU A 1 125 ? -0.89759  38.74509 -63.26385 1.000 63.94374  ? 123 GLU A N   1 
ATOM   979  C  CA  . GLU A 1 125 ? -0.92782  37.28762 -63.29427 1.000 63.48125  ? 123 GLU A CA  1 
ATOM   980  C  C   . GLU A 1 125 ? -1.07666  36.65238 -61.91381 1.000 64.30429  ? 123 GLU A C   1 
ATOM   981  O  O   . GLU A 1 125 ? -1.43346  35.47104 -61.83407 1.000 61.59675  ? 123 GLU A O   1 
ATOM   982  C  CB  . GLU A 1 125 ? 0.34720   36.79057 -63.98118 1.000 70.37607  ? 123 GLU A CB  1 
ATOM   983  C  CG  . GLU A 1 125 ? 0.34441   37.07285 -65.48271 1.000 83.88936  ? 123 GLU A CG  1 
ATOM   984  C  CD  . GLU A 1 125 ? 1.37151   36.25991 -66.24868 1.000 96.18039  ? 123 GLU A CD  1 
ATOM   985  O  OE1 . GLU A 1 125 ? 1.49368   35.04318 -65.97180 1.000 92.00074  ? 123 GLU A OE1 1 
ATOM   986  O  OE2 . GLU A 1 125 ? 2.03846   36.83723 -67.14202 1.000 101.89323 ? 123 GLU A OE2 1 
ATOM   987  N  N   . ASP A 1 126 ? -0.84039  37.39778 -60.83052 1.000 57.75357  ? 124 ASP A N   1 
ATOM   988  C  CA  . ASP A 1 126 ? -0.83238  36.83120 -59.48752 1.000 53.65142  ? 124 ASP A CA  1 
ATOM   989  C  C   . ASP A 1 126 ? -2.08240  37.17416 -58.67387 1.000 58.32383  ? 124 ASP A C   1 
ATOM   990  O  O   . ASP A 1 126 ? -2.20686  36.70379 -57.53901 1.000 51.54873  ? 124 ASP A O   1 
ATOM   991  C  CB  . ASP A 1 126 ? 0.43591   37.28703 -58.73853 1.000 51.79246  ? 124 ASP A CB  1 
ATOM   992  C  CG  . ASP A 1 126 ? 0.54128   38.82055 -58.57441 1.000 62.69622  ? 124 ASP A CG  1 
ATOM   993  O  OD1 . ASP A 1 126 ? 1.27489   39.25625 -57.64571 1.000 58.65310  ? 124 ASP A OD1 1 
ATOM   994  O  OD2 . ASP A 1 126 ? -0.15437  39.58633 -59.29753 1.000 57.73422  ? 124 ASP A OD2 1 
ATOM   995  N  N   . ALA A 1 127 ? -3.00774  37.97252 -59.22041 1.000 57.60093  ? 125 ALA A N   1 
ATOM   996  C  CA  . ALA A 1 127 ? -4.24857  38.29524 -58.52349 1.000 54.50776  ? 125 ALA A CA  1 
ATOM   997  C  C   . ALA A 1 127 ? -5.11523  37.04882 -58.39081 1.000 53.07958  ? 125 ALA A C   1 
ATOM   998  O  O   . ALA A 1 127 ? -5.41778  36.38274 -59.38642 1.000 55.98958  ? 125 ALA A O   1 
ATOM   999  C  CB  . ALA A 1 127 ? -5.01133  39.38897 -59.27244 1.000 47.97307  ? 125 ALA A CB  1 
ATOM   1000 N  N   . THR A 1 128 ? -5.51373  36.73309 -57.16070 1.000 47.40568  ? 126 THR A N   1 
ATOM   1001 C  CA  . THR A 1 128 ? -6.27459  35.52525 -56.89677 1.000 44.85112  ? 126 THR A CA  1 
ATOM   1002 C  C   . THR A 1 128 ? -7.31754  35.77822 -55.81375 1.000 49.55008  ? 126 THR A C   1 
ATOM   1003 O  O   . THR A 1 128 ? -7.06482  36.49274 -54.83530 1.000 45.55827  ? 126 THR A O   1 
ATOM   1004 C  CB  . THR A 1 128 ? -5.35614  34.37810 -56.46679 1.000 52.95717  ? 126 THR A CB  1 
ATOM   1005 O  OG1 . THR A 1 128 ? -6.15061  33.27131 -56.01684 1.000 58.28801  ? 126 THR A OG1 1 
ATOM   1006 C  CG2 . THR A 1 128 ? -4.43937  34.82338 -55.31909 1.000 47.74854  ? 126 THR A CG2 1 
ATOM   1007 N  N   . GLY A 1 129 ? -8.48682  35.16204 -55.98778 1.000 54.40390  ? 127 GLY A N   1 
ATOM   1008 C  CA  . GLY A 1 129 ? -9.54014  35.20113 -54.98773 1.000 42.07873  ? 127 GLY A CA  1 
ATOM   1009 C  C   . GLY A 1 129 ? -9.17145  34.57586 -53.66154 1.000 50.17419  ? 127 GLY A C   1 
ATOM   1010 O  O   . GLY A 1 129 ? -9.84066  34.85892 -52.65985 1.000 46.41348  ? 127 GLY A O   1 
ATOM   1011 N  N   . LEU A 1 130 ? -8.11327  33.76190 -53.61359 1.000 47.52773  ? 128 LEU A N   1 
ATOM   1012 C  CA  . LEU A 1 130 ? -7.64387  33.29684 -52.31422 1.000 49.91100  ? 128 LEU A CA  1 
ATOM   1013 C  C   . LEU A 1 130 ? -7.28082  34.45533 -51.39588 1.000 46.30081  ? 128 LEU A C   1 
ATOM   1014 O  O   . LEU A 1 130 ? -7.20669  34.26802 -50.18016 1.000 53.34945  ? 128 LEU A O   1 
ATOM   1015 C  CB  . LEU A 1 130 ? -6.45462  32.34758 -52.48013 1.000 51.28921  ? 128 LEU A CB  1 
ATOM   1016 C  CG  . LEU A 1 130 ? -6.82682  31.01110 -53.14263 1.000 58.87651  ? 128 LEU A CG  1 
ATOM   1017 C  CD1 . LEU A 1 130 ? -5.71676  30.53663 -54.07092 1.000 63.52035  ? 128 LEU A CD1 1 
ATOM   1018 C  CD2 . LEU A 1 130 ? -7.18520  29.93313 -52.12702 1.000 55.85264  ? 128 LEU A CD2 1 
ATOM   1019 N  N   . ASP A 1 131 ? -7.09516  35.65586 -51.93302 1.000 45.45157  ? 129 ASP A N   1 
ATOM   1020 C  CA  . ASP A 1 131 ? -6.77640  36.80673 -51.10212 1.000 52.72397  ? 129 ASP A CA  1 
ATOM   1021 C  C   . ASP A 1 131 ? -7.98550  37.67024 -50.79356 1.000 50.05525  ? 129 ASP A C   1 
ATOM   1022 O  O   . ASP A 1 131 ? -7.81370  38.80122 -50.32852 1.000 52.13863  ? 129 ASP A O   1 
ATOM   1023 C  CB  . ASP A 1 131 ? -5.68546  37.65639 -51.76568 1.000 54.35127  ? 129 ASP A CB  1 
ATOM   1024 C  CG  . ASP A 1 131 ? -4.35203  36.93076 -51.83374 1.000 58.92759  ? 129 ASP A CG  1 
ATOM   1025 O  OD1 . ASP A 1 131 ? -3.91119  36.41132 -50.77971 1.000 58.79621  ? 129 ASP A OD1 1 
ATOM   1026 O  OD2 . ASP A 1 131 ? -3.75934  36.86502 -52.94357 1.000 53.58495  ? 129 ASP A OD2 1 
ATOM   1027 N  N   . SER A 1 132 ? -9.19615  37.17614 -51.05105 1.000 53.95720  ? 130 SER A N   1 
ATOM   1028 C  CA  . SER A 1 132 ? -10.40049 37.92606 -50.72781 1.000 48.60526  ? 130 SER A CA  1 
ATOM   1029 C  C   . SER A 1 132 ? -10.45344 38.18817 -49.22462 1.000 44.65336  ? 130 SER A C   1 
ATOM   1030 O  O   . SER A 1 132 ? -10.42322 37.23525 -48.42937 1.000 45.32178  ? 130 SER A O   1 
ATOM   1031 C  CB  . SER A 1 132 ? -11.65339 37.17338 -51.19511 1.000 50.07902  ? 130 SER A CB  1 
ATOM   1032 O  OG  . SER A 1 132 ? -12.82677 37.60580 -50.50513 1.000 48.96366  ? 130 SER A OG  1 
ATOM   1033 N  N   . PRO A 1 133 ? -10.49539 39.44534 -48.79049 1.000 45.79963  ? 131 PRO A N   1 
ATOM   1034 C  CA  . PRO A 1 133 ? -10.72726 39.69432 -47.35543 1.000 44.73625  ? 131 PRO A CA  1 
ATOM   1035 C  C   . PRO A 1 133 ? -12.06665 39.15429 -46.89434 1.000 43.49052  ? 131 PRO A C   1 
ATOM   1036 O  O   . PRO A 1 133 ? -12.16602 38.60362 -45.78897 1.000 45.14475  ? 131 PRO A O   1 
ATOM   1037 C  CB  . PRO A 1 133 ? -10.64337 41.22586 -47.22979 1.000 41.52137  ? 131 PRO A CB  1 
ATOM   1038 C  CG  . PRO A 1 133 ? -9.95921  41.69277 -48.51497 1.000 50.12818  ? 131 PRO A CG  1 
ATOM   1039 C  CD  . PRO A 1 133 ? -10.29485 40.67618 -49.56980 1.000 43.83528  ? 131 PRO A CD  1 
ATOM   1040 N  N   . GLY A 1 134 ? -13.09991 39.26705 -47.73231 1.000 40.08824  ? 132 GLY A N   1 
ATOM   1041 C  CA  . GLY A 1 134 ? -14.40406 38.76556 -47.33679 1.000 43.44007  ? 132 GLY A CA  1 
ATOM   1042 C  C   . GLY A 1 134 ? -14.39500 37.26923 -47.10911 1.000 47.63144  ? 132 GLY A C   1 
ATOM   1043 O  O   . GLY A 1 134 ? -14.86446 36.77572 -46.07580 1.000 40.68272  ? 132 GLY A O   1 
ATOM   1044 N  N   . TYR A 1 135 ? -13.83344 36.52554 -48.06444 1.000 45.25969  ? 133 TYR A N   1 
ATOM   1045 C  CA  . TYR A 1 135 ? -13.77245 35.08264 -47.91041 1.000 43.94377  ? 133 TYR A CA  1 
ATOM   1046 C  C   . TYR A 1 135 ? -12.84997 34.67448 -46.76686 1.000 46.75697  ? 133 TYR A C   1 
ATOM   1047 O  O   . TYR A 1 135 ? -13.17936 33.76643 -45.99748 1.000 49.37448  ? 133 TYR A O   1 
ATOM   1048 C  CB  . TYR A 1 135 ? -13.32171 34.42544 -49.20873 1.000 49.40938  ? 133 TYR A CB  1 
ATOM   1049 C  CG  . TYR A 1 135 ? -13.65408 32.96184 -49.19241 1.000 56.27809  ? 133 TYR A CG  1 
ATOM   1050 C  CD1 . TYR A 1 135 ? -14.98971 32.53601 -49.13378 1.000 56.34926  ? 133 TYR A CD1 1 
ATOM   1051 C  CD2 . TYR A 1 135 ? -12.65078 32.00368 -49.16367 1.000 56.55152  ? 133 TYR A CD2 1 
ATOM   1052 C  CE1 . TYR A 1 135 ? -15.31337 31.19114 -49.07862 1.000 63.36972  ? 133 TYR A CE1 1 
ATOM   1053 C  CE2 . TYR A 1 135 ? -12.96001 30.64692 -49.10917 1.000 64.88968  ? 133 TYR A CE2 1 
ATOM   1054 C  CZ  . TYR A 1 135 ? -14.29095 30.24815 -49.06596 1.000 74.59352  ? 133 TYR A CZ  1 
ATOM   1055 O  OH  . TYR A 1 135 ? -14.59517 28.90510 -49.01330 1.000 84.06911  ? 133 TYR A OH  1 
ATOM   1056 N  N   . ARG A 1 136 ? -11.69338 35.32646 -46.63652 1.000 43.67244  ? 134 ARG A N   1 
ATOM   1057 C  CA  . ARG A 1 136 ? -10.73000 34.91758 -45.61572 1.000 49.89247  ? 134 ARG A CA  1 
ATOM   1058 C  C   . ARG A 1 136 ? -11.28018 35.14933 -44.21078 1.000 51.42102  ? 134 ARG A C   1 
ATOM   1059 O  O   . ARG A 1 136 ? -11.21970 34.25684 -43.35769 1.000 49.65171  ? 134 ARG A O   1 
ATOM   1060 C  CB  . ARG A 1 136 ? -9.41302  35.66491 -45.81076 1.000 52.28185  ? 134 ARG A CB  1 
ATOM   1061 C  CG  . ARG A 1 136 ? -8.46460  35.00179 -46.81397 1.000 64.37595  ? 134 ARG A CG  1 
ATOM   1062 C  CD  . ARG A 1 136 ? -7.25408  35.90062 -47.09309 1.000 75.63601  ? 134 ARG A CD  1 
ATOM   1063 N  NE  . ARG A 1 136 ? -6.21776  35.72442 -46.07942 1.000 92.51378  ? 134 ARG A NE  1 
ATOM   1064 C  CZ  . ARG A 1 136 ? -5.14398  34.95815 -46.22692 1.000 97.34637  ? 134 ARG A CZ  1 
ATOM   1065 N  NH1 . ARG A 1 136 ? -4.90933  34.30490 -47.35933 1.000 88.37473  ? 134 ARG A NH1 1 
ATOM   1066 N  NH2 . ARG A 1 136 ? -4.28592  34.84181 -45.21327 1.000 89.55035  ? 134 ARG A NH2 1 
ATOM   1067 N  N   . ASN A 1 137 ? -11.84305 36.33980 -43.95510 1.000 44.65988  ? 135 ASN A N   1 
ATOM   1068 C  CA  . ASN A 1 137 ? -12.37142 36.61375 -42.62250 1.000 46.44098  ? 135 ASN A CA  1 
ATOM   1069 C  C   . ASN A 1 137 ? -13.58063 35.74851 -42.31155 1.000 46.72855  ? 135 ASN A C   1 
ATOM   1070 O  O   . ASN A 1 137 ? -13.80479 35.38800 -41.14967 1.000 48.80012  ? 135 ASN A O   1 
ATOM   1071 C  CB  . ASN A 1 137 ? -12.71189 38.09221 -42.48642 1.000 44.97845  ? 135 ASN A CB  1 
ATOM   1072 C  CG  . ASN A 1 137 ? -11.47979 38.96000 -42.53380 1.000 49.62023  ? 135 ASN A CG  1 
ATOM   1073 O  OD1 . ASN A 1 137 ? -10.54936 38.75378 -41.76718 1.000 63.31463  ? 135 ASN A OD1 1 
ATOM   1074 N  ND2 . ASN A 1 137 ? -11.45021 39.91309 -43.44474 1.000 49.74271  ? 135 ASN A ND2 1 
ATOM   1075 N  N   . LEU A 1 138 ? -14.36002 35.38989 -43.32959 1.000 47.28356  ? 136 LEU A N   1 
ATOM   1076 C  CA  . LEU A 1 138 ? -15.49673 34.51484 -43.08635 1.000 50.45556  ? 136 LEU A CA  1 
ATOM   1077 C  C   . LEU A 1 138 ? -15.02301 33.14764 -42.61027 1.000 50.96376  ? 136 LEU A C   1 
ATOM   1078 O  O   . LEU A 1 138 ? -15.59281 32.57848 -41.67186 1.000 48.16605  ? 136 LEU A O   1 
ATOM   1079 C  CB  . LEU A 1 138 ? -16.36124 34.40858 -44.34548 1.000 47.24361  ? 136 LEU A CB  1 
ATOM   1080 C  CG  . LEU A 1 138 ? -17.47576 33.36115 -44.34786 1.000 49.64692  ? 136 LEU A CG  1 
ATOM   1081 C  CD1 . LEU A 1 138 ? -18.54321 33.68289 -43.32006 1.000 49.30073  ? 136 LEU A CD1 1 
ATOM   1082 C  CD2 . LEU A 1 138 ? -18.10440 33.23886 -45.73923 1.000 49.51132  ? 136 LEU A CD2 1 
ATOM   1083 N  N   . ARG A 1 139 ? -13.94637 32.62631 -43.20572 1.000 54.05705  ? 137 ARG A N   1 
ATOM   1084 C  CA  . ARG A 1 139 ? -13.40330 31.35207 -42.73692 1.000 52.67644  ? 137 ARG A CA  1 
ATOM   1085 C  C   . ARG A 1 139 ? -12.81681 31.48266 -41.33538 1.000 48.76771  ? 137 ARG A C   1 
ATOM   1086 O  O   . ARG A 1 139 ? -12.95313 30.56882 -40.51700 1.000 50.36835  ? 137 ARG A O   1 
ATOM   1087 C  CB  . ARG A 1 139 ? -12.35321 30.83232 -43.71238 1.000 54.36994  ? 137 ARG A CB  1 
ATOM   1088 C  CG  . ARG A 1 139 ? -12.89495 30.53235 -45.12297 1.000 63.09164  ? 137 ARG A CG  1 
ATOM   1089 C  CD  . ARG A 1 139 ? -12.72092 29.06139 -45.48802 1.000 74.08491  ? 137 ARG A CD  1 
ATOM   1090 N  NE  . ARG A 1 139 ? -13.89599 28.27055 -45.13796 1.000 82.08071  ? 137 ARG A NE  1 
ATOM   1091 C  CZ  . ARG A 1 139 ? -13.85962 26.99977 -44.75672 1.000 79.19500  ? 137 ARG A CZ  1 
ATOM   1092 N  NH1 . ARG A 1 139 ? -12.71492 26.34026 -44.64932 1.000 75.12472  ? 137 ARG A NH1 1 
ATOM   1093 N  NH2 . ARG A 1 139 ? -14.99835 26.38101 -44.45448 1.000 74.11316  ? 137 ARG A NH2 1 
ATOM   1094 N  N   . ARG A 1 140 ? -12.18735 32.61980 -41.02801 1.000 44.14068  ? 138 ARG A N   1 
ATOM   1095 C  CA  . ARG A 1 140 ? -11.60365 32.79604 -39.70156 1.000 50.24475  ? 138 ARG A CA  1 
ATOM   1096 C  C   . ARG A 1 140 ? -12.68197 32.90519 -38.63078 1.000 54.82095  ? 138 ARG A C   1 
ATOM   1097 O  O   . ARG A 1 140 ? -12.52964 32.35114 -37.53824 1.000 58.56487  ? 138 ARG A O   1 
ATOM   1098 C  CB  . ARG A 1 140 ? -10.68867 34.02382 -39.68115 1.000 52.64552  ? 138 ARG A CB  1 
ATOM   1099 C  CG  . ARG A 1 140 ? -9.50679  33.88316 -40.63693 1.000 62.07063  ? 138 ARG A CG  1 
ATOM   1100 C  CD  . ARG A 1 140 ? -8.46531  35.00510 -40.53416 1.000 74.18684  ? 138 ARG A CD  1 
ATOM   1101 N  NE  . ARG A 1 140 ? -8.95316  36.20663 -39.86784 1.000 78.09014  ? 138 ARG A NE  1 
ATOM   1102 C  CZ  . ARG A 1 140 ? -8.45505  36.68393 -38.73400 1.000 82.74883  ? 138 ARG A CZ  1 
ATOM   1103 N  NH1 . ARG A 1 140 ? -7.49302  36.05135 -38.08092 1.000 87.55700  ? 138 ARG A NH1 1 
ATOM   1104 N  NH2 . ARG A 1 140 ? -8.92844  37.82844 -38.24689 1.000 77.00294  ? 138 ARG A NH2 1 
ATOM   1105 N  N   . VAL A 1 141 ? -13.78433 33.60141 -38.92834 1.000 53.16105  ? 139 VAL A N   1 
ATOM   1106 C  CA  . VAL A 1 141 ? -14.80767 33.83288 -37.91623 1.000 49.08275  ? 139 VAL A CA  1 
ATOM   1107 C  C   . VAL A 1 141 ? -15.69224 32.61491 -37.70506 1.000 48.19680  ? 139 VAL A C   1 
ATOM   1108 O  O   . VAL A 1 141 ? -16.38032 32.53291 -36.67854 1.000 50.30942  ? 139 VAL A O   1 
ATOM   1109 C  CB  . VAL A 1 141 ? -15.65941 35.06183 -38.27587 1.000 56.45222  ? 139 VAL A CB  1 
ATOM   1110 C  CG1 . VAL A 1 141 ? -16.78889 34.69098 -39.26168 1.000 46.66396  ? 139 VAL A CG1 1 
ATOM   1111 C  CG2 . VAL A 1 141 ? -16.20921 35.71484 -37.00541 1.000 47.37373  ? 139 VAL A CG2 1 
ATOM   1112 N  N   . ALA A 1 142 ? -15.67222 31.65345 -38.63265 1.000 47.19875  ? 140 ALA A N   1 
ATOM   1113 C  CA  . ALA A 1 142 ? -16.49287 30.45367 -38.48568 1.000 48.44734  ? 140 ALA A CA  1 
ATOM   1114 C  C   . ALA A 1 142 ? -16.09411 29.64143 -37.26268 1.000 53.18309  ? 140 ALA A C   1 
ATOM   1115 O  O   . ALA A 1 142 ? -16.94907 28.99943 -36.63870 1.000 51.87139  ? 140 ALA A O   1 
ATOM   1116 C  CB  . ALA A 1 142 ? -16.39261 29.58899 -39.73945 1.000 43.98461  ? 140 ALA A CB  1 
ATOM   1117 N  N   . ARG A 1 143 ? -14.80036 29.67042 -36.89788 1.000 59.32972  ? 141 ARG A N   1 
ATOM   1118 C  CA  . ARG A 1 143 ? -14.33735 28.91858 -35.73239 1.000 58.12644  ? 141 ARG A CA  1 
ATOM   1119 C  C   . ARG A 1 143 ? -14.93198 29.45164 -34.42845 1.000 55.42109  ? 141 ARG A C   1 
ATOM   1120 O  O   . ARG A 1 143 ? -15.61139 28.68628 -33.71846 1.000 52.82685  ? 141 ARG A O   1 
ATOM   1121 C  CB  . ARG A 1 143 ? -12.80448 28.87693 -35.72482 1.000 65.76985  ? 141 ARG A CB  1 
ATOM   1122 C  CG  . ARG A 1 143 ? -12.27114 27.78223 -36.62540 1.000 68.23238  ? 141 ARG A CG  1 
ATOM   1123 C  CD  . ARG A 1 143 ? -12.76443 26.45852 -36.05416 1.000 84.84982  ? 141 ARG A CD  1 
ATOM   1124 N  NE  . ARG A 1 143 ? -13.80526 25.82635 -36.86694 1.000 91.26417  ? 141 ARG A NE  1 
ATOM   1125 C  CZ  . ARG A 1 143 ? -14.67858 24.93684 -36.40138 1.000 81.63561  ? 141 ARG A CZ  1 
ATOM   1126 N  NH1 . ARG A 1 143 ? -14.68107 24.56943 -35.12804 1.000 80.90026  ? 141 ARG A NH1 1 
ATOM   1127 N  NH2 . ARG A 1 143 ? -15.59322 24.42840 -37.22334 1.000 75.45565  ? 141 ARG A NH2 1 
ATOM   1128 N  N   . PRO A 1 144 ? -14.75353 30.73057 -34.06507 1.000 48.34612  ? 142 PRO A N   1 
ATOM   1129 C  CA  . PRO A 1 144 ? -15.43078 31.22575 -32.85665 1.000 45.41996  ? 142 PRO A CA  1 
ATOM   1130 C  C   . PRO A 1 144 ? -16.94387 31.09576 -32.91844 1.000 54.46373  ? 142 PRO A C   1 
ATOM   1131 O  O   . PRO A 1 144 ? -17.58088 30.90977 -31.87011 1.000 51.52279  ? 142 PRO A O   1 
ATOM   1132 C  CB  . PRO A 1 144 ? -15.00773 32.70099 -32.78813 1.000 44.27721  ? 142 PRO A CB  1 
ATOM   1133 C  CG  . PRO A 1 144 ? -13.84907 32.82085 -33.65071 1.000 45.35189  ? 142 PRO A CG  1 
ATOM   1134 C  CD  . PRO A 1 144 ? -13.98599 31.80007 -34.72359 1.000 49.38085  ? 142 PRO A CD  1 
ATOM   1135 N  N   . VAL A 1 145 ? -17.55032 31.20312 -34.10861 1.000 47.59964  ? 143 VAL A N   1 
ATOM   1136 C  CA  . VAL A 1 145 ? -18.99908 31.04730 -34.18811 1.000 46.45291  ? 143 VAL A CA  1 
ATOM   1137 C  C   . VAL A 1 145 ? -19.38173 29.65067 -33.74428 1.000 46.12709  ? 143 VAL A C   1 
ATOM   1138 O  O   . VAL A 1 145 ? -20.25542 29.46065 -32.88299 1.000 45.67155  ? 143 VAL A O   1 
ATOM   1139 C  CB  . VAL A 1 145 ? -19.52183 31.34099 -35.60779 1.000 46.73907  ? 143 VAL A CB  1 
ATOM   1140 C  CG1 . VAL A 1 145 ? -20.95620 30.81860 -35.73975 1.000 41.25438  ? 143 VAL A CG1 1 
ATOM   1141 C  CG2 . VAL A 1 145 ? -19.47236 32.81610 -35.90498 1.000 42.02809  ? 143 VAL A CG2 1 
ATOM   1142 N  N   . TRP A 1 146 ? -18.69989 28.64879 -34.29782 1.000 48.77455  ? 144 TRP A N   1 
ATOM   1143 C  CA  . TRP A 1 146 ? -19.00362 27.28545 -33.90075 1.000 48.21043  ? 144 TRP A CA  1 
ATOM   1144 C  C   . TRP A 1 146 ? -18.72912 27.06518 -32.41234 1.000 49.65500  ? 144 TRP A C   1 
ATOM   1145 O  O   . TRP A 1 146 ? -19.51910 26.41133 -31.71974 1.000 46.40401  ? 144 TRP A O   1 
ATOM   1146 C  CB  . TRP A 1 146 ? -18.22406 26.27972 -34.74729 1.000 48.97124  ? 144 TRP A CB  1 
ATOM   1147 C  CG  . TRP A 1 146 ? -18.50630 24.95725 -34.17946 1.000 62.05687  ? 144 TRP A CG  1 
ATOM   1148 C  CD1 . TRP A 1 146 ? -17.67356 24.19476 -33.41316 1.000 53.53089  ? 144 TRP A CD1 1 
ATOM   1149 C  CD2 . TRP A 1 146 ? -19.76376 24.27611 -34.21252 1.000 58.05331  ? 144 TRP A CD2 1 
ATOM   1150 N  NE1 . TRP A 1 146 ? -18.32539 23.06047 -33.00192 1.000 66.36717  ? 144 TRP A NE1 1 
ATOM   1151 C  CE2 . TRP A 1 146 ? -19.60942 23.08306 -33.47814 1.000 64.46269  ? 144 TRP A CE2 1 
ATOM   1152 C  CE3 . TRP A 1 146 ? -20.99778 24.54540 -34.81517 1.000 54.50220  ? 144 TRP A CE3 1 
ATOM   1153 C  CZ2 . TRP A 1 146 ? -20.64239 22.16127 -33.32381 1.000 60.57423  ? 144 TRP A CZ2 1 
ATOM   1154 C  CZ3 . TRP A 1 146 ? -22.02793 23.62939 -34.66014 1.000 58.67436  ? 144 TRP A CZ3 1 
ATOM   1155 C  CH2 . TRP A 1 146 ? -21.84213 22.44998 -33.92312 1.000 63.76773  ? 144 TRP A CH2 1 
ATOM   1156 N  N   . LYS A 1 147 ? -17.61753 27.59647 -31.89437 1.000 49.46179  ? 145 LYS A N   1 
ATOM   1157 C  CA  . LYS A 1 147 ? -17.34618 27.42024 -30.46798 1.000 57.18736  ? 145 LYS A CA  1 
ATOM   1158 C  C   . LYS A 1 147 ? -18.48358 27.98170 -29.62320 1.000 56.79602  ? 145 LYS A C   1 
ATOM   1159 O  O   . LYS A 1 147 ? -18.96445 27.31822 -28.69286 1.000 53.36239  ? 145 LYS A O   1 
ATOM   1160 C  CB  . LYS A 1 147 ? -16.02451 28.07816 -30.07385 1.000 62.94087  ? 145 LYS A CB  1 
ATOM   1161 C  CG  . LYS A 1 147 ? -14.99850 27.11722 -29.50297 1.000 73.84717  ? 145 LYS A CG  1 
ATOM   1162 C  CD  . LYS A 1 147 ? -14.39918 26.21724 -30.60362 1.000 87.42778  ? 145 LYS A CD  1 
ATOM   1163 C  CE  . LYS A 1 147 ? -13.13122 26.85147 -31.22258 1.000 88.45678  ? 145 LYS A CE  1 
ATOM   1164 N  NZ  . LYS A 1 147 ? -12.55249 26.06598 -32.35655 1.000 85.08279  ? 145 LYS A NZ  1 
ATOM   1165 N  N   . ALA A 1 148 ? -18.94196 29.20197 -29.94654 1.000 49.92110  ? 146 ALA A N   1 
ATOM   1166 C  CA  . ALA A 1 148 ? -19.99099 29.82264 -29.13938 1.000 51.45117  ? 146 ALA A CA  1 
ATOM   1167 C  C   . ALA A 1 148 ? -21.26015 28.98153 -29.14564 1.000 50.32404  ? 146 ALA A C   1 
ATOM   1168 O  O   . ALA A 1 148 ? -21.89254 28.79436 -28.09759 1.000 50.41376  ? 146 ALA A O   1 
ATOM   1169 C  CB  . ALA A 1 148 ? -20.27704 31.23823 -29.63034 1.000 45.84625  ? 146 ALA A CB  1 
ATOM   1170 N  N   . TYR A 1 149 ? -21.62624 28.42992 -30.30880 1.000 47.59861  ? 147 TYR A N   1 
ATOM   1171 C  CA  . TYR A 1 149 ? -22.79708 27.56266 -30.36917 1.000 45.94097  ? 147 TYR A CA  1 
ATOM   1172 C  C   . TYR A 1 149 ? -22.58741 26.29279 -29.54786 1.000 49.70200  ? 147 TYR A C   1 
ATOM   1173 O  O   . TYR A 1 149 ? -23.46188 25.88618 -28.77099 1.000 48.49790  ? 147 TYR A O   1 
ATOM   1174 C  CB  . TYR A 1 149 ? -23.13827 27.19647 -31.81857 1.000 41.08413  ? 147 TYR A CB  1 
ATOM   1175 C  CG  . TYR A 1 149 ? -24.38589 26.33672 -31.86480 1.000 40.92260  ? 147 TYR A CG  1 
ATOM   1176 C  CD1 . TYR A 1 149 ? -25.62088 26.86236 -31.48461 1.000 39.12319  ? 147 TYR A CD1 1 
ATOM   1177 C  CD2 . TYR A 1 149 ? -24.32885 24.99487 -32.23270 1.000 43.86455  ? 147 TYR A CD2 1 
ATOM   1178 C  CE1 . TYR A 1 149 ? -26.77968 26.07906 -31.49535 1.000 42.26483  ? 147 TYR A CE1 1 
ATOM   1179 C  CE2 . TYR A 1 149 ? -25.47898 24.19794 -32.24620 1.000 41.08314  ? 147 TYR A CE2 1 
ATOM   1180 C  CZ  . TYR A 1 149 ? -26.69840 24.75153 -31.87293 1.000 43.75310  ? 147 TYR A CZ  1 
ATOM   1181 O  OH  . TYR A 1 149 ? -27.83880 23.98601 -31.88628 1.000 43.63349  ? 147 TYR A OH  1 
ATOM   1182 N  N   . GLU A 1 150 ? -21.43680 25.63854 -29.72110 1.000 52.66912  ? 148 GLU A N   1 
ATOM   1183 C  CA  . GLU A 1 150 ? -21.18346 24.41005 -28.97699 1.000 55.91671  ? 148 GLU A CA  1 
ATOM   1184 C  C   . GLU A 1 150 ? -21.19717 24.65435 -27.47601 1.000 52.20174  ? 148 GLU A C   1 
ATOM   1185 O  O   . GLU A 1 150 ? -21.80240 23.88616 -26.72484 1.000 54.23329  ? 148 GLU A O   1 
ATOM   1186 C  CB  . GLU A 1 150 ? -19.85720 23.80949 -29.39248 1.000 61.81357  ? 148 GLU A CB  1 
ATOM   1187 C  CG  . GLU A 1 150 ? -19.64984 22.43679 -28.84035 1.000 70.25655  ? 148 GLU A CG  1 
ATOM   1188 C  CD  . GLU A 1 150 ? -18.34698 21.85576 -29.31589 1.000 87.84038  ? 148 GLU A CD  1 
ATOM   1189 O  OE1 . GLU A 1 150 ? -17.29175 22.38139 -28.90042 1.000 86.95030  ? 148 GLU A OE1 1 
ATOM   1190 O  OE2 . GLU A 1 150 ? -18.38026 20.89727 -30.12724 1.000 96.78358  ? 148 GLU A OE2 1 
ATOM   1191 N  N   . GLN A 1 151 ? -20.56063 25.73160 -27.02242 1.000 48.81823  ? 149 GLN A N   1 
ATOM   1192 C  CA  . GLN A 1 151 ? -20.58473 26.03588 -25.59752 1.000 55.18486  ? 149 GLN A CA  1 
ATOM   1193 C  C   . GLN A 1 151 ? -22.00668 26.26425 -25.10657 1.000 59.83339  ? 149 GLN A C   1 
ATOM   1194 O  O   . GLN A 1 151 ? -22.38825 25.77601 -24.03497 1.000 62.36089  ? 149 GLN A O   1 
ATOM   1195 C  CB  . GLN A 1 151 ? -19.71280 27.24966 -25.30293 1.000 51.11464  ? 149 GLN A CB  1 
ATOM   1196 C  CG  . GLN A 1 151 ? -18.25553 26.89282 -25.04793 1.000 50.92075  ? 149 GLN A CG  1 
ATOM   1197 C  CD  . GLN A 1 151 ? -17.30959 28.06874 -25.25976 1.000 73.46068  ? 149 GLN A CD  1 
ATOM   1198 O  OE1 . GLN A 1 151 ? -17.72727 29.18791 -25.58969 1.000 77.21514  ? 149 GLN A OE1 1 
ATOM   1199 N  NE2 . GLN A 1 151 ? -16.02577 27.81985 -25.06402 1.000 77.14428  ? 149 GLN A NE2 1 
ATOM   1200 N  N   . ALA A 1 152 ? -22.81557 26.98645 -25.88527 1.000 62.39520  ? 150 ALA A N   1 
ATOM   1201 C  CA  . ALA A 1 152 ? -24.18342 27.25584 -25.45624 1.000 56.63193  ? 150 ALA A CA  1 
ATOM   1202 C  C   . ALA A 1 152 ? -24.97518 25.97021 -25.30773 1.000 55.34762  ? 150 ALA A C   1 
ATOM   1203 O  O   . ALA A 1 152 ? -25.81417 25.85856 -24.40507 1.000 56.63389  ? 150 ALA A O   1 
ATOM   1204 C  CB  . ALA A 1 152 ? -24.86902 28.19309 -26.44677 1.000 57.17693  ? 150 ALA A CB  1 
ATOM   1205 N  N   . VAL A 1 153 ? -24.71367 24.98881 -26.17581 1.000 53.99040  ? 151 VAL A N   1 
ATOM   1206 C  CA  . VAL A 1 153 ? -25.40905 23.70770 -26.09215 1.000 58.59969  ? 151 VAL A CA  1 
ATOM   1207 C  C   . VAL A 1 153 ? -24.95050 22.91777 -24.86794 1.000 65.53254  ? 151 VAL A C   1 
ATOM   1208 O  O   . VAL A 1 153 ? -25.76006 22.27292 -24.18744 1.000 63.03681  ? 151 VAL A O   1 
ATOM   1209 C  CB  . VAL A 1 153 ? -25.19401 22.91279 -27.38805 1.000 61.32617  ? 151 VAL A CB  1 
ATOM   1210 C  CG1 . VAL A 1 153 ? -25.70949 21.47436 -27.21582 1.000 57.60978  ? 151 VAL A CG1 1 
ATOM   1211 C  CG2 . VAL A 1 153 ? -25.86797 23.63713 -28.57213 1.000 52.70499  ? 151 VAL A CG2 1 
ATOM   1212 N  N   . GLU A 1 154 ? -23.64534 22.94680 -24.57863 1.000 64.55427  ? 152 GLU A N   1 
ATOM   1213 C  CA  . GLU A 1 154 ? -23.11922 22.32273 -23.37087 1.000 63.63314  ? 152 GLU A CA  1 
ATOM   1214 C  C   . GLU A 1 154 ? -23.78685 22.89307 -22.12688 1.000 63.38789  ? 152 GLU A C   1 
ATOM   1215 O  O   . GLU A 1 154 ? -24.41225 22.15668 -21.35962 1.000 63.96819  ? 152 GLU A O   1 
ATOM   1216 C  CB  . GLU A 1 154 ? -21.60571 22.51314 -23.29676 1.000 58.27177  ? 152 GLU A CB  1 
ATOM   1217 C  CG  . GLU A 1 154 ? -20.82611 21.50809 -24.11968 1.000 66.19766  ? 152 GLU A CG  1 
ATOM   1218 C  CD  . GLU A 1 154 ? -19.43890 22.01612 -24.53662 1.000 80.17031  ? 152 GLU A CD  1 
ATOM   1219 O  OE1 . GLU A 1 154 ? -19.01687 23.10148 -24.07153 1.000 84.27952  ? 152 GLU A OE1 1 
ATOM   1220 O  OE2 . GLU A 1 154 ? -18.75516 21.31196 -25.31395 1.000 82.01627  ? 152 GLU A OE2 1 
ATOM   1221 N  N   . ARG A 1 155 ? -23.66232 24.21139 -21.91132 1.000 60.27011  ? 153 ARG A N   1 
ATOM   1222 C  CA  . ARG A 1 155 ? -24.26620 24.83767 -20.73408 1.000 53.69623  ? 153 ARG A CA  1 
ATOM   1223 C  C   . ARG A 1 155 ? -25.71088 24.41094 -20.56076 1.000 60.15260  ? 153 ARG A C   1 
ATOM   1224 O  O   . ARG A 1 155 ? -26.18380 24.23220 -19.43656 1.000 67.98018  ? 153 ARG A O   1 
ATOM   1225 C  CB  . ARG A 1 155 ? -24.21406 26.36008 -20.82780 1.000 48.61368  ? 153 ARG A CB  1 
ATOM   1226 C  CG  . ARG A 1 155 ? -22.84345 26.95681 -20.87136 1.000 54.28386  ? 153 ARG A CG  1 
ATOM   1227 C  CD  . ARG A 1 155 ? -22.91862 28.45198 -20.56492 1.000 53.08486  ? 153 ARG A CD  1 
ATOM   1228 N  NE  . ARG A 1 155 ? -23.60134 29.21917 -21.60703 1.000 71.57011  ? 153 ARG A NE  1 
ATOM   1229 C  CZ  . ARG A 1 155 ? -23.04527 29.62349 -22.74810 1.000 66.24563  ? 153 ARG A CZ  1 
ATOM   1230 N  NH1 . ARG A 1 155 ? -21.80605 29.29180 -23.07627 1.000 64.98072  ? 153 ARG A NH1 1 
ATOM   1231 N  NH2 . ARG A 1 155 ? -23.74891 30.38545 -23.57956 1.000 57.89651  ? 153 ARG A NH2 1 
ATOM   1232 N  N   . ALA A 1 156 ? -26.43569 24.25230 -21.65970 1.000 63.42157  ? 154 ALA A N   1 
ATOM   1233 C  CA  . ALA A 1 156 ? -27.81324 23.81409 -21.51290 1.000 64.59795  ? 154 ALA A CA  1 
ATOM   1234 C  C   . ALA A 1 156 ? -27.91580 22.33336 -21.18458 1.000 59.97682  ? 154 ALA A C   1 
ATOM   1235 O  O   . ALA A 1 156 ? -29.02731 21.84157 -20.97982 1.000 60.92269  ? 154 ALA A O   1 
ATOM   1236 C  CB  . ALA A 1 156 ? -28.59559 24.13216 -22.78780 1.000 55.50617  ? 154 ALA A CB  1 
ATOM   1237 N  N   . GLY A 1 157 ? -26.79159 21.62108 -21.13665 1.000 61.11412  ? 155 GLY A N   1 
ATOM   1238 C  CA  . GLY A 1 157 ? -26.78016 20.18282 -20.95294 1.000 60.30879  ? 155 GLY A CA  1 
ATOM   1239 C  C   . GLY A 1 157 ? -27.51525 19.40739 -22.02770 1.000 67.70603  ? 155 GLY A C   1 
ATOM   1240 O  O   . GLY A 1 157 ? -28.25363 18.46673 -21.71949 1.000 70.38382  ? 155 GLY A O   1 
ATOM   1241 N  N   . LEU A 1 158 ? -27.32941 19.76371 -23.29306 1.000 62.48303  ? 156 LEU A N   1 
ATOM   1242 C  CA  . LEU A 1 158 ? -28.12110 19.13810 -24.33963 1.000 65.43987  ? 156 LEU A CA  1 
ATOM   1243 C  C   . LEU A 1 158 ? -27.25431 18.30262 -25.26541 1.000 60.81866  ? 156 LEU A C   1 
ATOM   1244 O  O   . LEU A 1 158 ? -26.03944 18.49706 -25.37792 1.000 59.97014  ? 156 LEU A O   1 
ATOM   1245 C  CB  . LEU A 1 158 ? -28.88594 20.18176 -25.15721 1.000 71.73269  ? 156 LEU A CB  1 
ATOM   1246 C  CG  . LEU A 1 158 ? -30.19468 20.65208 -24.52162 1.000 65.72614  ? 156 LEU A CG  1 
ATOM   1247 C  CD1 . LEU A 1 158 ? -30.50627 22.06462 -24.97689 1.000 66.08756  ? 156 LEU A CD1 1 
ATOM   1248 C  CD2 . LEU A 1 158 ? -31.32560 19.68408 -24.85895 1.000 65.56883  ? 156 LEU A CD2 1 
ATOM   1249 N  N   . SER A 1 159 ? -27.91257 17.35610 -25.91825 1.000 62.82124  ? 157 SER A N   1 
ATOM   1250 C  CA  . SER A 1 159 ? -27.30414 16.56138 -26.97099 1.000 69.72783  ? 157 SER A CA  1 
ATOM   1251 C  C   . SER A 1 159 ? -27.61726 17.17809 -28.33259 1.000 71.08227  ? 157 SER A C   1 
ATOM   1252 O  O   . SER A 1 159 ? -28.75199 17.58372 -28.60257 1.000 62.54921  ? 157 SER A O   1 
ATOM   1253 C  CB  . SER A 1 159 ? -27.82278 15.12503 -26.91387 1.000 64.29048  ? 157 SER A CB  1 
ATOM   1254 O  OG  . SER A 1 159 ? -27.42486 14.40733 -28.06150 1.000 70.22508  ? 157 SER A OG  1 
ATOM   1255 N  N   . LEU A 1 160 ? -26.60010 17.25535 -29.18874 1.000 63.20042  ? 158 LEU A N   1 
ATOM   1256 C  CA  . LEU A 1 160 ? -26.83139 17.73218 -30.54384 1.000 58.77475  ? 158 LEU A CA  1 
ATOM   1257 C  C   . LEU A 1 160 ? -27.88248 16.89291 -31.26056 1.000 66.21886  ? 158 LEU A C   1 
ATOM   1258 O  O   . LEU A 1 160 ? -28.64992 17.42304 -32.07343 1.000 68.56149  ? 158 LEU A O   1 
ATOM   1259 C  CB  . LEU A 1 160 ? -25.52126 17.73550 -31.32417 1.000 63.21653  ? 158 LEU A CB  1 
ATOM   1260 C  CG  . LEU A 1 160 ? -25.32926 18.76283 -32.43554 1.000 63.23783  ? 158 LEU A CG  1 
ATOM   1261 C  CD1 . LEU A 1 160 ? -25.69451 20.16272 -31.96933 1.000 59.62679  ? 158 LEU A CD1 1 
ATOM   1262 C  CD2 . LEU A 1 160 ? -23.88365 18.71428 -32.92297 1.000 59.24043  ? 158 LEU A CD2 1 
ATOM   1263 N  N   . GLN A 1 161 ? -27.95348 15.59413 -30.96393 1.000 59.39612  ? 159 GLN A N   1 
ATOM   1264 C  CA  . GLN A 1 161 ? -29.00444 14.77239 -31.55729 1.000 60.92940  ? 159 GLN A CA  1 
ATOM   1265 C  C   . GLN A 1 161 ? -30.37492 15.15375 -31.01612 1.000 59.31559  ? 159 GLN A C   1 
ATOM   1266 O  O   . GLN A 1 161 ? -31.37899 15.06067 -31.73338 1.000 57.42412  ? 159 GLN A O   1 
ATOM   1267 C  CB  . GLN A 1 161 ? -28.71826 13.29566 -31.30233 1.000 55.79249  ? 159 GLN A CB  1 
ATOM   1268 C  CG  . GLN A 1 161 ? -27.50500 12.79157 -32.05684 1.000 61.22673  ? 159 GLN A CG  1 
ATOM   1269 C  CD  . GLN A 1 161 ? -27.74089 12.73795 -33.55110 1.000 65.72329  ? 159 GLN A CD  1 
ATOM   1270 O  OE1 . GLN A 1 161 ? -28.77996 12.25407 -34.00952 1.000 65.04683  ? 159 GLN A OE1 1 
ATOM   1271 N  NE2 . GLN A 1 161 ? -26.78214 13.24339 -34.32047 1.000 55.19280  ? 159 GLN A NE2 1 
ATOM   1272 N  N   . ASP A 1 162 ? -30.43476 15.54932 -29.74094 1.000 64.15888  ? 160 ASP A N   1 
ATOM   1273 C  CA  . ASP A 1 162 ? -31.67064 16.06608 -29.15705 1.000 71.59129  ? 160 ASP A CA  1 
ATOM   1274 C  C   . ASP A 1 162 ? -32.14415 17.29370 -29.91616 1.000 67.35030  ? 160 ASP A C   1 
ATOM   1275 O  O   . ASP A 1 162 ? -33.33399 17.43311 -30.23903 1.000 56.78451  ? 160 ASP A O   1 
ATOM   1276 C  CB  . ASP A 1 162 ? -31.43097 16.43633 -27.68909 1.000 76.98725  ? 160 ASP A CB  1 
ATOM   1277 C  CG  . ASP A 1 162 ? -31.65933 15.28115 -26.73099 1.000 93.99945  ? 160 ASP A CG  1 
ATOM   1278 O  OD1 . ASP A 1 162 ? -31.43387 15.49623 -25.50951 1.000 92.37496  ? 160 ASP A OD1 1 
ATOM   1279 O  OD2 . ASP A 1 162 ? -32.06731 14.18187 -27.18933 1.000 93.36118  ? 160 ASP A OD2 1 
ATOM   1280 N  N   . VAL A 1 163 ? -31.20738 18.20627 -30.18263 1.000 59.19953  ? 161 VAL A N   1 
ATOM   1281 C  CA  . VAL A 1 163 ? -31.51183 19.44678 -30.87810 1.000 59.74883  ? 161 VAL A CA  1 
ATOM   1282 C  C   . VAL A 1 163 ? -32.03579 19.15841 -32.28093 1.000 60.26254  ? 161 VAL A C   1 
ATOM   1283 O  O   . VAL A 1 163 ? -33.00282 19.78090 -32.73718 1.000 59.76643  ? 161 VAL A O   1 
ATOM   1284 C  CB  . VAL A 1 163 ? -30.25820 20.33629 -30.89520 1.000 59.94528  ? 161 VAL A CB  1 
ATOM   1285 C  CG1 . VAL A 1 163 ? -30.54515 21.64586 -31.56335 1.000 54.32865  ? 161 VAL A CG1 1 
ATOM   1286 C  CG2 . VAL A 1 163 ? -29.76779 20.56630 -29.46803 1.000 60.53975  ? 161 VAL A CG2 1 
ATOM   1287 N  N   . ILE A 1 164 ? -31.43444 18.18610 -32.97381 1.000 54.81418  ? 162 ILE A N   1 
ATOM   1288 C  CA  . ILE A 1 164 ? -31.88686 17.85859 -34.32048 1.000 52.56319  ? 162 ILE A CA  1 
ATOM   1289 C  C   . ILE A 1 164 ? -33.29806 17.27624 -34.28938 1.000 58.68827  ? 162 ILE A C   1 
ATOM   1290 O  O   . ILE A 1 164 ? -34.15672 17.65424 -35.09595 1.000 59.87544  ? 162 ILE A O   1 
ATOM   1291 C  CB  . ILE A 1 164 ? -30.89644 16.89990 -35.00584 1.000 56.81143  ? 162 ILE A CB  1 
ATOM   1292 C  CG1 . ILE A 1 164 ? -29.58077 17.61040 -35.31708 1.000 48.89920  ? 162 ILE A CG1 1 
ATOM   1293 C  CG2 . ILE A 1 164 ? -31.50552 16.34526 -36.29043 1.000 51.74061  ? 162 ILE A CG2 1 
ATOM   1294 C  CD1 . ILE A 1 164 ? -28.38718 16.69236 -35.33556 1.000 51.35521  ? 162 ILE A CD1 1 
ATOM   1295 N  N   . ALA A 1 165 ? -33.57093 16.36651 -33.35030 1.000 55.25590  ? 163 ALA A N   1 
ATOM   1296 C  CA  . ALA A 1 165 ? -34.85983 15.67811 -33.34799 1.000 57.80350  ? 163 ALA A CA  1 
ATOM   1297 C  C   . ALA A 1 165 ? -36.02718 16.63577 -33.12310 1.000 53.88925  ? 163 ALA A C   1 
ATOM   1298 O  O   . ALA A 1 165 ? -37.10323 16.44225 -33.70092 1.000 55.62957  ? 163 ALA A O   1 
ATOM   1299 C  CB  . ALA A 1 165 ? -34.86682 14.56977 -32.28621 1.000 55.39576  ? 163 ALA A CB  1 
ATOM   1300 N  N   . GLN A 1 166 ? -35.83705 17.67457 -32.30102 1.000 58.89579  ? 164 GLN A N   1 
ATOM   1301 C  CA  . GLN A 1 166 ? -36.91275 18.60236 -31.93992 1.000 61.53702  ? 164 GLN A CA  1 
ATOM   1302 C  C   . GLN A 1 166 ? -37.41887 19.46688 -33.09867 1.000 60.59313  ? 164 GLN A C   1 
ATOM   1303 O  O   . GLN A 1 166 ? -38.47619 20.09586 -32.95413 1.000 59.02903  ? 164 GLN A O   1 
ATOM   1304 C  CB  . GLN A 1 166 ? -36.44736 19.50461 -30.80605 1.000 53.00332  ? 164 GLN A CB  1 
ATOM   1305 C  CG  . GLN A 1 166 ? -36.42797 18.79198 -29.48783 1.000 67.32091  ? 164 GLN A CG  1 
ATOM   1306 C  CD  . GLN A 1 166 ? -35.85182 19.64574 -28.39621 1.000 66.93847  ? 164 GLN A CD  1 
ATOM   1307 O  OE1 . GLN A 1 166 ? -36.25777 20.79677 -28.21800 1.000 67.46700  ? 164 GLN A OE1 1 
ATOM   1308 N  NE2 . GLN A 1 166 ? -34.89400 19.09466 -27.65589 1.000 67.51783  ? 164 GLN A NE2 1 
ATOM   1309 N  N   . GLN A 1 167 ? -36.69242 19.53882 -34.22115 1.000 53.59722  ? 165 GLN A N   1 
ATOM   1310 C  CA  . GLN A 1 167 ? -37.22713 20.17756 -35.42281 1.000 57.14099  ? 165 GLN A CA  1 
ATOM   1311 C  C   . GLN A 1 167 ? -38.44233 19.43947 -35.98360 1.000 55.00020  ? 165 GLN A C   1 
ATOM   1312 O  O   . GLN A 1 167 ? -39.25208 20.05556 -36.68948 1.000 57.77091  ? 165 GLN A O   1 
ATOM   1313 C  CB  . GLN A 1 167 ? -36.13385 20.27163 -36.48681 1.000 54.76999  ? 165 GLN A CB  1 
ATOM   1314 C  CG  . GLN A 1 167 ? -36.50720 21.05302 -37.71289 1.000 50.28605  ? 165 GLN A CG  1 
ATOM   1315 C  CD  . GLN A 1 167 ? -35.42762 20.98649 -38.77625 1.000 56.15656  ? 165 GLN A CD  1 
ATOM   1316 O  OE1 . GLN A 1 167 ? -34.40461 20.30562 -38.60565 1.000 58.04930  ? 165 GLN A OE1 1 
ATOM   1317 N  NE2 . GLN A 1 167 ? -35.63839 21.70310 -39.87502 1.000 53.38628  ? 165 GLN A NE2 1 
ATOM   1318 N  N   . ASP A 1 168 ? -38.58749 18.14486 -35.67185 1.000 53.73611  ? 166 ASP A N   1 
ATOM   1319 C  CA  . ASP A 1 168 ? -39.69575 17.32085 -36.14986 1.000 54.19268  ? 166 ASP A CA  1 
ATOM   1320 C  C   . ASP A 1 168 ? -40.92169 17.48386 -35.24399 1.000 58.90421  ? 166 ASP A C   1 
ATOM   1321 O  O   . ASP A 1 168 ? -40.82649 17.33958 -34.02089 1.000 56.07254  ? 166 ASP A O   1 
ATOM   1322 C  CB  . ASP A 1 168 ? -39.23738 15.85857 -36.20532 1.000 54.74480  ? 166 ASP A CB  1 
ATOM   1323 C  CG  . ASP A 1 168 ? -40.31919 14.88407 -36.72020 1.000 64.63961  ? 166 ASP A CG  1 
ATOM   1324 O  OD1 . ASP A 1 168 ? -41.47005 15.28730 -37.01333 1.000 57.38932  ? 166 ASP A OD1 1 
ATOM   1325 O  OD2 . ASP A 1 168 ? -39.99600 13.67647 -36.82701 1.000 65.36276  ? 166 ASP A OD2 1 
ATOM   1326 N  N   . ASP A 1 169 ? -42.07802 17.78825 -35.84849 1.000 57.66184  ? 167 ASP A N   1 
ATOM   1327 C  CA  . ASP A 1 169 ? -43.30939 17.91097 -35.06801 1.000 61.99334  ? 167 ASP A CA  1 
ATOM   1328 C  C   . ASP A 1 169 ? -43.75104 16.57595 -34.47866 1.000 66.25208  ? 167 ASP A C   1 
ATOM   1329 O  O   . ASP A 1 169 ? -44.45293 16.55305 -33.46191 1.000 68.66692  ? 167 ASP A O   1 
ATOM   1330 C  CB  . ASP A 1 169 ? -44.43738 18.47294 -35.92824 1.000 64.33024  ? 167 ASP A CB  1 
ATOM   1331 C  CG  . ASP A 1 169 ? -44.45310 19.98467 -35.95882 1.000 64.54293  ? 167 ASP A CG  1 
ATOM   1332 O  OD1 . ASP A 1 169 ? -43.57474 20.61633 -35.32460 1.000 60.07918  ? 167 ASP A OD1 1 
ATOM   1333 O  OD2 . ASP A 1 169 ? -45.34587 20.53315 -36.63975 1.000 62.24581  ? 167 ASP A OD2 1 
ATOM   1334 N  N   . GLY A 1 170 ? -43.37682 15.46084 -35.11305 1.000 69.89388  ? 168 GLY A N   1 
ATOM   1335 C  CA  . GLY A 1 170 ? -43.72897 14.14816 -34.60203 1.000 63.73327  ? 168 GLY A CA  1 
ATOM   1336 C  C   . GLY A 1 170 ? -42.89023 13.67120 -33.43353 1.000 68.99332  ? 168 GLY A C   1 
ATOM   1337 O  O   . GLY A 1 170 ? -43.32522 12.77317 -32.70621 1.000 71.85494  ? 168 GLY A O   1 
ATOM   1338 N  N   . TYR A 1 171 ? -41.70868 14.25666 -33.22975 1.000 65.89230  ? 169 TYR A N   1 
ATOM   1339 C  CA  . TYR A 1 171 ? -40.82868 13.83114 -32.14757 1.000 64.07646  ? 169 TYR A CA  1 
ATOM   1340 C  C   . TYR A 1 171 ? -41.50033 14.00824 -30.78358 1.000 77.25812  ? 169 TYR A C   1 
ATOM   1341 O  O   . TYR A 1 171 ? -42.11939 15.04000 -30.49942 1.000 68.97733  ? 169 TYR A O   1 
ATOM   1342 C  CB  . TYR A 1 171 ? -39.52563 14.61707 -32.21176 1.000 59.61234  ? 169 TYR A CB  1 
ATOM   1343 C  CG  . TYR A 1 171 ? -38.56874 14.32585 -31.09132 1.000 67.38497  ? 169 TYR A CG  1 
ATOM   1344 C  CD1 . TYR A 1 171 ? -38.00558 13.06014 -30.94337 1.000 67.00561  ? 169 TYR A CD1 1 
ATOM   1345 C  CD2 . TYR A 1 171 ? -38.21271 15.31909 -30.18304 1.000 65.42385  ? 169 TYR A CD2 1 
ATOM   1346 C  CE1 . TYR A 1 171 ? -37.11461 12.79135 -29.92284 1.000 58.74446  ? 169 TYR A CE1 1 
ATOM   1347 C  CE2 . TYR A 1 171 ? -37.32029 15.06584 -29.15917 1.000 67.19693  ? 169 TYR A CE2 1 
ATOM   1348 C  CZ  . TYR A 1 171 ? -36.77126 13.79686 -29.03344 1.000 71.93957  ? 169 TYR A CZ  1 
ATOM   1349 O  OH  . TYR A 1 171 ? -35.87980 13.53461 -28.01509 1.000 73.39010  ? 169 TYR A OH  1 
ATOM   1350 N  N   . ASP A 1 172 ? -41.36449 12.98314 -29.93095 1.000 82.10750  ? 170 ASP A N   1 
ATOM   1351 C  CA  . ASP A 1 172 ? -42.10192 12.88887 -28.67610 1.000 76.89382  ? 170 ASP A CA  1 
ATOM   1352 C  C   . ASP A 1 172 ? -41.26367 13.13307 -27.43195 1.000 73.61370  ? 170 ASP A C   1 
ATOM   1353 O  O   . ASP A 1 172 ? -41.83096 13.22269 -26.33929 1.000 71.60569  ? 170 ASP A O   1 
ATOM   1354 C  CB  . ASP A 1 172 ? -42.74900 11.50628 -28.54323 1.000 86.98266  ? 170 ASP A CB  1 
ATOM   1355 C  CG  . ASP A 1 172 ? -44.19365 11.50821 -28.95968 1.000 101.33772 ? 170 ASP A CG  1 
ATOM   1356 O  OD1 . ASP A 1 172 ? -44.69012 10.44104 -29.38877 1.000 108.55090 ? 170 ASP A OD1 1 
ATOM   1357 O  OD2 . ASP A 1 172 ? -44.82161 12.58940 -28.88322 1.000 102.25127 ? 170 ASP A OD2 1 
ATOM   1358 N  N   . GLY A 1 173 ? -39.94555 13.22702 -27.55936 1.000 71.59531  ? 171 GLY A N   1 
ATOM   1359 C  CA  . GLY A 1 173 ? -39.07491 13.38347 -26.42139 1.000 68.56200  ? 171 GLY A CA  1 
ATOM   1360 C  C   . GLY A 1 173 ? -39.22574 14.71742 -25.72375 1.000 71.47219  ? 171 GLY A C   1 
ATOM   1361 O  O   . GLY A 1 173 ? -40.10258 15.52736 -26.04283 1.000 70.75913  ? 171 GLY A O   1 
ATOM   1362 N  N   . PRO A 1 174 ? -38.35602 14.96670 -24.74970 1.000 77.42853  ? 172 PRO A N   1 
ATOM   1363 C  CA  . PRO A 1 174 ? -38.45690 16.19930 -23.95844 1.000 74.71532  ? 172 PRO A CA  1 
ATOM   1364 C  C   . PRO A 1 174 ? -38.10189 17.43546 -24.77068 1.000 69.68531  ? 172 PRO A C   1 
ATOM   1365 O  O   . PRO A 1 174 ? -37.23282 17.40483 -25.64652 1.000 71.20486  ? 172 PRO A O   1 
ATOM   1366 C  CB  . PRO A 1 174 ? -37.43873 15.98365 -22.82586 1.000 69.19015  ? 172 PRO A CB  1 
ATOM   1367 C  CG  . PRO A 1 174 ? -37.01541 14.55999 -22.91372 1.000 63.99286  ? 172 PRO A CG  1 
ATOM   1368 C  CD  . PRO A 1 174 ? -37.23597 14.11551 -24.32069 1.000 71.59241  ? 172 PRO A CD  1 
ATOM   1369 N  N   . ARG A 1 175 ? -38.78606 18.53769 -24.45531 1.000 70.58175  ? 173 ARG A N   1 
ATOM   1370 C  CA  . ARG A 1 175 ? -38.49794 19.84910 -25.02747 1.000 64.23029  ? 173 ARG A CA  1 
ATOM   1371 C  C   . ARG A 1 175 ? -38.59281 20.89955 -23.93671 1.000 60.80209  ? 173 ARG A C   1 
ATOM   1372 O  O   . ARG A 1 175 ? -39.56459 20.92072 -23.17788 1.000 71.27032  ? 173 ARG A O   1 
ATOM   1373 C  CB  . ARG A 1 175 ? -39.48369 20.23034 -26.13894 1.000 60.65735  ? 173 ARG A CB  1 
ATOM   1374 C  CG  . ARG A 1 175 ? -39.67823 19.22451 -27.23565 1.000 64.44145  ? 173 ARG A CG  1 
ATOM   1375 C  CD  . ARG A 1 175 ? -41.00338 19.48695 -27.92018 1.000 69.63118  ? 173 ARG A CD  1 
ATOM   1376 N  NE  . ARG A 1 175 ? -41.20439 18.62221 -29.07471 1.000 74.21274  ? 173 ARG A NE  1 
ATOM   1377 C  CZ  . ARG A 1 175 ? -40.99296 18.98612 -30.33278 1.000 65.88952  ? 173 ARG A CZ  1 
ATOM   1378 N  NH1 . ARG A 1 175 ? -40.56329 20.20124 -30.63807 1.000 67.74145  ? 173 ARG A NH1 1 
ATOM   1379 N  NH2 . ARG A 1 175 ? -41.22143 18.10890 -31.30830 1.000 59.46491  ? 173 ARG A NH2 1 
ATOM   1380 N  N   . SER A 1 176 ? -37.60223 21.77108 -23.87014 1.000 63.23686  ? 174 SER A N   1 
ATOM   1381 C  CA  . SER A 1 176 ? -37.69861 23.02072 -23.13178 1.000 62.87704  ? 174 SER A CA  1 
ATOM   1382 C  C   . SER A 1 176 ? -37.75622 24.18683 -24.11630 1.000 71.50207  ? 174 SER A C   1 
ATOM   1383 O  O   . SER A 1 176 ? -37.62768 24.02239 -25.33742 1.000 62.82070  ? 174 SER A O   1 
ATOM   1384 C  CB  . SER A 1 176 ? -36.51036 23.18347 -22.17926 1.000 60.12009  ? 174 SER A CB  1 
ATOM   1385 O  OG  . SER A 1 176 ? -35.28410 22.97233 -22.86360 1.000 61.33022  ? 174 SER A OG  1 
ATOM   1386 N  N   . GLY A 1 177 ? -37.95364 25.38587 -23.57149 1.000 70.75376  ? 175 GLY A N   1 
ATOM   1387 C  CA  . GLY A 1 177 ? -37.85735 26.57169 -24.40315 1.000 52.79373  ? 175 GLY A CA  1 
ATOM   1388 C  C   . GLY A 1 177 ? -36.44250 26.79520 -24.90155 1.000 63.14284  ? 175 GLY A C   1 
ATOM   1389 O  O   . GLY A 1 177 ? -36.23327 27.21216 -26.04327 1.000 60.97908  ? 175 GLY A O   1 
ATOM   1390 N  N   . GLY A 1 178 ? -35.45012 26.50364 -24.05952 1.000 61.83042  ? 176 GLY A N   1 
ATOM   1391 C  CA  . GLY A 1 178 ? -34.07108 26.69144 -24.46405 1.000 47.25183  ? 176 GLY A CA  1 
ATOM   1392 C  C   . GLY A 1 178 ? -33.60731 25.67664 -25.48761 1.000 57.31800  ? 176 GLY A C   1 
ATOM   1393 O  O   . GLY A 1 178 ? -32.80273 26.00447 -26.36859 1.000 56.79920  ? 176 GLY A O   1 
ATOM   1394 N  N   . SER A 1 179 ? -34.09256 24.43423 -25.39447 1.000 52.34676  ? 177 SER A N   1 
ATOM   1395 C  CA  . SER A 1 179 ? -33.64885 23.44666 -26.36701 1.000 59.33689  ? 177 SER A CA  1 
ATOM   1396 C  C   . SER A 1 179 ? -34.23984 23.74471 -27.74127 1.000 51.24875  ? 177 SER A C   1 
ATOM   1397 O  O   . SER A 1 179 ? -33.55599 23.59677 -28.75848 1.000 53.86621  ? 177 SER A O   1 
ATOM   1398 C  CB  . SER A 1 179 ? -33.99183 22.02436 -25.90190 1.000 52.22024  ? 177 SER A CB  1 
ATOM   1399 O  OG  . SER A 1 179 ? -35.37378 21.72879 -26.01266 1.000 48.65877  ? 177 SER A OG  1 
ATOM   1400 N  N   . GLN A 1 180 ? -35.49791 24.18903 -27.78879 1.000 51.18847  ? 178 GLN A N   1 
ATOM   1401 C  CA  . GLN A 1 180 ? -36.12442 24.51797 -29.06600 1.000 54.50615  ? 178 GLN A CA  1 
ATOM   1402 C  C   . GLN A 1 180 ? -35.54898 25.79690 -29.66724 1.000 50.58040  ? 178 GLN A C   1 
ATOM   1403 O  O   . GLN A 1 180 ? -35.47031 25.91772 -30.89123 1.000 50.84583  ? 178 GLN A O   1 
ATOM   1404 C  CB  . GLN A 1 180 ? -37.63560 24.63590 -28.89281 1.000 52.03872  ? 178 GLN A CB  1 
ATOM   1405 C  CG  . GLN A 1 180 ? -38.28185 23.35260 -28.41190 1.000 52.73385  ? 178 GLN A CG  1 
ATOM   1406 C  CD  . GLN A 1 180 ? -39.75799 23.26923 -28.76250 1.000 64.13973  ? 178 GLN A CD  1 
ATOM   1407 O  OE1 . GLN A 1 180 ? -40.14105 22.69541 -29.79168 1.000 67.34679  ? 178 GLN A OE1 1 
ATOM   1408 N  NE2 . GLN A 1 180 ? -40.60008 23.84563 -27.90590 1.000 64.00180  ? 178 GLN A NE2 1 
ATOM   1409 N  N   . SER A 1 181 ? -35.12196 26.74314 -28.83089 1.000 51.01585  ? 179 SER A N   1 
ATOM   1410 C  CA  . SER A 1 181 ? -34.38301 27.90093 -29.32165 1.000 49.14395  ? 179 SER A CA  1 
ATOM   1411 C  C   . SER A 1 181 ? -33.05144 27.49075 -29.93478 1.000 49.53121  ? 179 SER A C   1 
ATOM   1412 O  O   . SER A 1 181 ? -32.68521 27.94628 -31.02624 1.000 51.51229  ? 179 SER A O   1 
ATOM   1413 C  CB  . SER A 1 181 ? -34.16247 28.88588 -28.18135 1.000 49.18541  ? 179 SER A CB  1 
ATOM   1414 O  OG  . SER A 1 181 ? -35.40024 29.47039 -27.85195 1.000 60.00050  ? 179 SER A OG  1 
ATOM   1415 N  N   . LEU A 1 182 ? -32.30493 26.63601 -29.24105 1.000 47.60321  ? 180 LEU A N   1 
ATOM   1416 C  CA  . LEU A 1 182 ? -31.05807 26.14714 -29.80640 1.000 50.09355  ? 180 LEU A CA  1 
ATOM   1417 C  C   . LEU A 1 182 ? -31.31329 25.35389 -31.08080 1.000 46.58316  ? 180 LEU A C   1 
ATOM   1418 O  O   . LEU A 1 182 ? -30.47433 25.35109 -31.98781 1.000 41.57318  ? 180 LEU A O   1 
ATOM   1419 C  CB  . LEU A 1 182 ? -30.30514 25.32454 -28.75576 1.000 50.99493  ? 180 LEU A CB  1 
ATOM   1420 C  CG  . LEU A 1 182 ? -29.66402 26.28247 -27.74258 1.000 54.22345  ? 180 LEU A CG  1 
ATOM   1421 C  CD1 . LEU A 1 182 ? -29.22561 25.59632 -26.45181 1.000 55.60950  ? 180 LEU A CD1 1 
ATOM   1422 C  CD2 . LEU A 1 182 ? -28.49446 26.98019 -28.40269 1.000 49.17548  ? 180 LEU A CD2 1 
ATOM   1423 N  N   . ALA A 1 183 ? -32.47816 24.70653 -31.18396 1.000 42.22201  ? 181 ALA A N   1 
ATOM   1424 C  CA  . ALA A 1 183 ? -32.84345 24.05393 -32.43378 1.000 44.80416  ? 181 ALA A CA  1 
ATOM   1425 C  C   . ALA A 1 183 ? -32.97046 25.07511 -33.57248 1.000 51.38684  ? 181 ALA A C   1 
ATOM   1426 O  O   . ALA A 1 183 ? -32.37601 24.89776 -34.64170 1.000 47.06144  ? 181 ALA A O   1 
ATOM   1427 C  CB  . ALA A 1 183 ? -34.13326 23.25000 -32.25152 1.000 41.43473  ? 181 ALA A CB  1 
ATOM   1428 N  N   . LEU A 1 184 ? -33.71691 26.16909 -33.35335 1.000 44.18838  ? 182 LEU A N   1 
ATOM   1429 C  CA  . LEU A 1 184 ? -33.83397 27.19226 -34.39256 1.000 43.28709  ? 182 LEU A CA  1 
ATOM   1430 C  C   . LEU A 1 184 ? -32.47156 27.77075 -34.77447 1.000 42.02903  ? 182 LEU A C   1 
ATOM   1431 O  O   . LEU A 1 184 ? -32.22728 28.05802 -35.95443 1.000 43.32464  ? 182 LEU A O   1 
ATOM   1432 C  CB  . LEU A 1 184 ? -34.77548 28.30988 -33.95143 1.000 35.23518  ? 182 LEU A CB  1 
ATOM   1433 C  CG  . LEU A 1 184 ? -36.25137 27.96511 -33.76316 1.000 43.03047  ? 182 LEU A CG  1 
ATOM   1434 C  CD1 . LEU A 1 184 ? -37.04541 29.23254 -33.42340 1.000 45.51234  ? 182 LEU A CD1 1 
ATOM   1435 C  CD2 . LEU A 1 184 ? -36.83432 27.28124 -34.98388 1.000 39.96981  ? 182 LEU A CD2 1 
ATOM   1436 N  N   . VAL A 1 185 ? -31.57490 27.95185 -33.79778 1.000 38.76804  ? 183 VAL A N   1 
ATOM   1437 C  CA  . VAL A 1 185 ? -30.23183 28.44292 -34.10456 1.000 37.64491  ? 183 VAL A CA  1 
ATOM   1438 C  C   . VAL A 1 185 ? -29.50980 27.46248 -35.00814 1.000 44.70171  ? 183 VAL A C   1 
ATOM   1439 O  O   . VAL A 1 185 ? -28.89737 27.84871 -36.02001 1.000 42.52711  ? 183 VAL A O   1 
ATOM   1440 C  CB  . VAL A 1 185 ? -29.42374 28.67836 -32.82017 1.000 45.69557  ? 183 VAL A CB  1 
ATOM   1441 C  CG1 . VAL A 1 185 ? -27.95155 28.97604 -33.18492 1.000 34.03919  ? 183 VAL A CG1 1 
ATOM   1442 C  CG2 . VAL A 1 185 ? -30.04748 29.77903 -31.98653 1.000 39.38122  ? 183 VAL A CG2 1 
ATOM   1443 N  N   . ARG A 1 186 ? -29.55954 26.17474 -34.63952 1.000 42.85551  ? 184 ARG A N   1 
ATOM   1444 C  CA  . ARG A 1 186 ? -28.95874 25.11874 -35.45043 1.000 44.56673  ? 184 ARG A CA  1 
ATOM   1445 C  C   . ARG A 1 186 ? -29.41874 25.19284 -36.90501 1.000 43.49643  ? 184 ARG A C   1 
ATOM   1446 O  O   . ARG A 1 186 ? -28.59770 25.18047 -37.83238 1.000 44.98553  ? 184 ARG A O   1 
ATOM   1447 C  CB  . ARG A 1 186 ? -29.31882 23.75814 -34.86595 1.000 46.39314  ? 184 ARG A CB  1 
ATOM   1448 C  CG  . ARG A 1 186 ? -28.22412 22.72705 -35.00939 1.000 53.26222  ? 184 ARG A CG  1 
ATOM   1449 C  CD  . ARG A 1 186 ? -28.49094 21.73955 -36.11148 1.000 44.59342  ? 184 ARG A CD  1 
ATOM   1450 N  NE  . ARG A 1 186 ? -29.88067 21.31990 -36.21212 1.000 51.87409  ? 184 ARG A NE  1 
ATOM   1451 C  CZ  . ARG A 1 186 ? -30.34279 20.63815 -37.25208 1.000 52.45462  ? 184 ARG A CZ  1 
ATOM   1452 N  NH1 . ARG A 1 186 ? -29.54004 20.25596 -38.22567 1.000 52.38278  ? 184 ARG A NH1 1 
ATOM   1453 N  NH2 . ARG A 1 186 ? -31.64189 20.35329 -37.32635 1.000 53.43804  ? 184 ARG A NH2 1 
ATOM   1454 N  N   . GLU A 1 187 ? -30.73880 25.23897 -37.11726 1.000 38.63011  ? 185 GLU A N   1 
ATOM   1455 C  CA  . GLU A 1 187 ? -31.28683 25.25565 -38.47032 1.000 43.73710  ? 185 GLU A CA  1 
ATOM   1456 C  C   . GLU A 1 187 ? -30.83083 26.49091 -39.22710 1.000 40.98026  ? 185 GLU A C   1 
ATOM   1457 O  O   . GLU A 1 187 ? -30.46021 26.40126 -40.40650 1.000 42.28746  ? 185 GLU A O   1 
ATOM   1458 C  CB  . GLU A 1 187 ? -32.81524 25.15857 -38.41344 1.000 39.16169  ? 185 GLU A CB  1 
ATOM   1459 C  CG  . GLU A 1 187 ? -33.27474 24.06027 -37.43885 1.000 48.84612  ? 185 GLU A CG  1 
ATOM   1460 C  CD  . GLU A 1 187 ? -34.71935 24.19479 -36.89698 1.000 57.25745  ? 185 GLU A CD  1 
ATOM   1461 O  OE1 . GLU A 1 187 ? -35.01445 23.51751 -35.88226 1.000 58.09478  ? 185 GLU A OE1 1 
ATOM   1462 O  OE2 . GLU A 1 187 ? -35.54411 24.97827 -37.43705 1.000 59.17590  ? 185 GLU A OE2 1 
ATOM   1463 N  N   . ALA A 1 188 ? -30.80254 27.64273 -38.54978 1.000 40.21793  ? 186 ALA A N   1 
ATOM   1464 C  CA  . ALA A 1 188 ? -30.33999 28.86639 -39.19190 1.000 39.22383  ? 186 ALA A CA  1 
ATOM   1465 C  C   . ALA A 1 188 ? -28.86281 28.76638 -39.55718 1.000 35.22493  ? 186 ALA A C   1 
ATOM   1466 O  O   . ALA A 1 188 ? -28.43776 29.25175 -40.60978 1.000 48.14214  ? 186 ALA A O   1 
ATOM   1467 C  CB  . ALA A 1 188 ? -30.59864 30.06870 -38.28574 1.000 33.57914  ? 186 ALA A CB  1 
ATOM   1468 N  N   . MET A 1 189 ? -28.07619 28.11565 -38.71530 1.000 43.75912  ? 187 MET A N   1 
ATOM   1469 C  CA  . MET A 1 189 ? -26.66428 27.90449 -39.01016 1.000 42.28014  ? 187 MET A CA  1 
ATOM   1470 C  C   . MET A 1 189 ? -26.47810 26.97065 -40.19302 1.000 41.10438  ? 187 MET A C   1 
ATOM   1471 O  O   . MET A 1 189 ? -25.59359 27.18893 -41.03487 1.000 36.22321  ? 187 MET A O   1 
ATOM   1472 C  CB  . MET A 1 189 ? -25.97467 27.34212 -37.78295 1.000 45.14030  ? 187 MET A CB  1 
ATOM   1473 C  CG  . MET A 1 189 ? -25.47286 28.39262 -36.85527 1.000 47.33905  ? 187 MET A CG  1 
ATOM   1474 S  SD  . MET A 1 189 ? -25.02395 27.58702 -35.30963 1.000 51.27737  ? 187 MET A SD  1 
ATOM   1475 C  CE  . MET A 1 189 ? -23.25089 27.73255 -35.53915 1.000 42.79599  ? 187 MET A CE  1 
ATOM   1476 N  N   . LEU A 1 190 ? -27.29962 25.92747 -40.27566 1.000 39.62432  ? 188 LEU A N   1 
ATOM   1477 C  CA  . LEU A 1 190 ? -27.18062 24.99516 -41.39404 1.000 47.02715  ? 188 LEU A CA  1 
ATOM   1478 C  C   . LEU A 1 190 ? -27.60138 25.65182 -42.70644 1.000 41.49659  ? 188 LEU A C   1 
ATOM   1479 O  O   . LEU A 1 190 ? -27.01677 25.37125 -43.75818 1.000 41.39547  ? 188 LEU A O   1 
ATOM   1480 C  CB  . LEU A 1 190 ? -28.00801 23.73551 -41.12302 1.000 40.53864  ? 188 LEU A CB  1 
ATOM   1481 C  CG  . LEU A 1 190 ? -27.83241 22.60722 -42.13278 1.000 53.26766  ? 188 LEU A CG  1 
ATOM   1482 C  CD1 . LEU A 1 190 ? -26.40956 22.06589 -42.06148 1.000 51.28850  ? 188 LEU A CD1 1 
ATOM   1483 C  CD2 . LEU A 1 190 ? -28.85517 21.49807 -41.91422 1.000 55.21753  ? 188 LEU A CD2 1 
ATOM   1484 N  N   . ARG A 1 191 ? -28.60310 26.53843 -42.66344 1.000 42.28295  ? 189 ARG A N   1 
ATOM   1485 C  CA  . ARG A 1 191 ? -28.99353 27.26180 -43.87146 1.000 41.20249  ? 189 ARG A CA  1 
ATOM   1486 C  C   . ARG A 1 191 ? -27.87748 28.19298 -44.31475 1.000 40.60290  ? 189 ARG A C   1 
ATOM   1487 O  O   . ARG A 1 191 ? -27.60473 28.31627 -45.51479 1.000 40.34804  ? 189 ARG A O   1 
ATOM   1488 C  CB  . ARG A 1 191 ? -30.29829 28.04849 -43.64934 1.000 36.54596  ? 189 ARG A CB  1 
ATOM   1489 C  CG  . ARG A 1 191 ? -31.55275 27.17809 -43.61416 1.000 38.67818  ? 189 ARG A CG  1 
ATOM   1490 C  CD  . ARG A 1 191 ? -32.87772 27.97027 -43.56433 1.000 39.20530  ? 189 ARG A CD  1 
ATOM   1491 N  NE  . ARG A 1 191 ? -32.95079 28.92090 -42.45626 1.000 44.86717  ? 189 ARG A NE  1 
ATOM   1492 C  CZ  . ARG A 1 191 ? -33.45375 28.65543 -41.25219 1.000 41.41069  ? 189 ARG A CZ  1 
ATOM   1493 N  NH1 . ARG A 1 191 ? -33.89616 27.44704 -40.92843 1.000 39.87904  ? 189 ARG A NH1 1 
ATOM   1494 N  NH2 . ARG A 1 191 ? -33.49521 29.61989 -40.34598 1.000 36.14687  ? 189 ARG A NH2 1 
ATOM   1495 N  N   . LEU A 1 192 ? -27.18609 28.82725 -43.36531 1.000 39.33380  ? 190 LEU A N   1 
ATOM   1496 C  CA  . LEU A 1 192 ? -26.08679 29.69841 -43.76284 1.000 37.14111  ? 190 LEU A CA  1 
ATOM   1497 C  C   . LEU A 1 192 ? -24.99281 28.89367 -44.45289 1.000 41.32543  ? 190 LEU A C   1 
ATOM   1498 O  O   . LEU A 1 192 ? -24.54509 29.24590 -45.55484 1.000 46.98395  ? 190 LEU A O   1 
ATOM   1499 C  CB  . LEU A 1 192 ? -25.54743 30.45483 -42.55649 1.000 35.79622  ? 190 LEU A CB  1 
ATOM   1500 C  CG  . LEU A 1 192 ? -24.22669 31.16951 -42.80127 1.000 37.74504  ? 190 LEU A CG  1 
ATOM   1501 C  CD1 . LEU A 1 192 ? -24.37235 32.25995 -43.85896 1.000 28.81922  ? 190 LEU A CD1 1 
ATOM   1502 C  CD2 . LEU A 1 192 ? -23.72490 31.74587 -41.49115 1.000 36.56660  ? 190 LEU A CD2 1 
ATOM   1503 N  N   . ASP A 1 193 ? -24.60582 27.76448 -43.85416 1.000 39.91658  ? 191 ASP A N   1 
ATOM   1504 C  CA  . ASP A 1 193 ? -23.53478 26.94681 -44.41673 1.000 43.09903  ? 191 ASP A CA  1 
ATOM   1505 C  C   . ASP A 1 193 ? -23.92340 26.40584 -45.78834 1.000 42.08759  ? 191 ASP A C   1 
ATOM   1506 O  O   . ASP A 1 193 ? -23.10972 26.42267 -46.72098 1.000 43.33209  ? 191 ASP A O   1 
ATOM   1507 C  CB  . ASP A 1 193 ? -23.18828 25.80650 -43.45126 1.000 42.46565  ? 191 ASP A CB  1 
ATOM   1508 C  CG  . ASP A 1 193 ? -21.75058 25.28352 -43.61603 1.000 53.36353  ? 191 ASP A CG  1 
ATOM   1509 O  OD1 . ASP A 1 193 ? -21.01974 25.70536 -44.54306 1.000 58.15611  ? 191 ASP A OD1 1 
ATOM   1510 O  OD2 . ASP A 1 193 ? -21.34300 24.43068 -42.79801 1.000 56.00125  ? 191 ASP A OD2 1 
ATOM   1511 N  N   . GLY A 1 194 ? -25.17187 25.94305 -45.93388 1.000 39.81385  ? 192 GLY A N   1 
ATOM   1512 C  CA  . GLY A 1 194 ? -25.64899 25.51364 -47.23847 1.000 35.16161  ? 192 GLY A CA  1 
ATOM   1513 C  C   . GLY A 1 194 ? -25.59388 26.62198 -48.27200 1.000 42.15251  ? 192 GLY A C   1 
ATOM   1514 O  O   . GLY A 1 194 ? -25.27425 26.38606 -49.44034 1.000 43.55562  ? 192 GLY A O   1 
ATOM   1515 N  N   . SER A 1 195 ? -25.89967 27.84887 -47.85317 1.000 40.06492  ? 193 SER A N   1 
ATOM   1516 C  CA  . SER A 1 195 ? -25.79614 28.97954 -48.76003 1.000 39.77173  ? 193 SER A CA  1 
ATOM   1517 C  C   . SER A 1 195 ? -24.35312 29.17628 -49.21738 1.000 41.06166  ? 193 SER A C   1 
ATOM   1518 O  O   . SER A 1 195 ? -24.09620 29.38160 -50.40872 1.000 39.68077  ? 193 SER A O   1 
ATOM   1519 C  CB  . SER A 1 195 ? -26.34185 30.23436 -48.06755 1.000 41.66199  ? 193 SER A CB  1 
ATOM   1520 O  OG  . SER A 1 195 ? -26.16594 31.40610 -48.84801 1.000 43.12217  ? 193 SER A OG  1 
ATOM   1521 N  N   . VAL A 1 196 ? -23.39524 29.10273 -48.28697 1.000 40.42360  ? 194 VAL A N   1 
ATOM   1522 C  CA  . VAL A 1 196 ? -21.99559 29.29316 -48.66304 1.000 44.63844  ? 194 VAL A CA  1 
ATOM   1523 C  C   . VAL A 1 196 ? -21.50073 28.14171 -49.53893 1.000 43.72182  ? 194 VAL A C   1 
ATOM   1524 O  O   . VAL A 1 196 ? -20.78939 28.36608 -50.52584 1.000 44.98784  ? 194 VAL A O   1 
ATOM   1525 C  CB  . VAL A 1 196 ? -21.11618 29.47738 -47.41813 1.000 45.39314  ? 194 VAL A CB  1 
ATOM   1526 C  CG1 . VAL A 1 196 ? -19.69468 29.68788 -47.85687 1.000 43.48073  ? 194 VAL A CG1 1 
ATOM   1527 C  CG2 . VAL A 1 196 ? -21.60673 30.67438 -46.59312 1.000 37.68919  ? 194 VAL A CG2 1 
ATOM   1528 N  N   . LEU A 1 197 ? -21.88029 26.89732 -49.21853 1.000 39.53469  ? 195 LEU A N   1 
ATOM   1529 C  CA  . LEU A 1 197 ? -21.59505 25.80575 -50.14634 1.000 41.69335  ? 195 LEU A CA  1 
ATOM   1530 C  C   . LEU A 1 197 ? -22.17869 26.11273 -51.51708 1.000 42.14125  ? 195 LEU A C   1 
ATOM   1531 O  O   . LEU A 1 197 ? -21.53624 25.86855 -52.54692 1.000 44.87004  ? 195 LEU A O   1 
ATOM   1532 C  CB  . LEU A 1 197 ? -22.15786 24.48281 -49.62123 1.000 38.52709  ? 195 LEU A CB  1 
ATOM   1533 C  CG  . LEU A 1 197 ? -21.49676 23.94684 -48.35998 1.000 49.59394  ? 195 LEU A CG  1 
ATOM   1534 C  CD1 . LEU A 1 197 ? -22.24903 22.74130 -47.83208 1.000 43.72698  ? 195 LEU A CD1 1 
ATOM   1535 C  CD2 . LEU A 1 197 ? -20.02868 23.61071 -48.63767 1.000 47.00786  ? 195 LEU A CD2 1 
ATOM   1536 N  N   . GLY A 1 198 ? -23.39741 26.65904 -51.54346 1.000 37.40302  ? 196 GLY A N   1 
ATOM   1537 C  CA  . GLY A 1 198 ? -23.99694 27.04302 -52.80659 1.000 38.90265  ? 196 GLY A CA  1 
ATOM   1538 C  C   . GLY A 1 198 ? -23.13094 28.02203 -53.57224 1.000 40.57037  ? 196 GLY A C   1 
ATOM   1539 O  O   . GLY A 1 198 ? -22.87523 27.83162 -54.76237 1.000 40.69205  ? 196 GLY A O   1 
ATOM   1540 N  N   . TRP A 1 199 ? -22.63803 29.06563 -52.88595 1.000 38.84831  ? 197 TRP A N   1 
ATOM   1541 C  CA  . TRP A 1 199 ? -21.72427 30.01514 -53.51859 1.000 38.39166  ? 197 TRP A CA  1 
ATOM   1542 C  C   . TRP A 1 199 ? -20.53840 29.29114 -54.14404 1.000 39.10557  ? 197 TRP A C   1 
ATOM   1543 O  O   . TRP A 1 199 ? -20.18888 29.53169 -55.30508 1.000 35.92818  ? 197 TRP A O   1 
ATOM   1544 C  CB  . TRP A 1 199 ? -21.21642 31.07540 -52.51677 1.000 37.98269  ? 197 TRP A CB  1 
ATOM   1545 C  CG  . TRP A 1 199 ? -20.33565 32.07374 -53.24296 1.000 39.98277  ? 197 TRP A CG  1 
ATOM   1546 C  CD1 . TRP A 1 199 ? -20.74978 33.18152 -53.91901 1.000 43.38237  ? 197 TRP A CD1 1 
ATOM   1547 C  CD2 . TRP A 1 199 ? -18.91680 31.99021 -53.44741 1.000 40.29466  ? 197 TRP A CD2 1 
ATOM   1548 N  NE1 . TRP A 1 199 ? -19.68119 33.81112 -54.51115 1.000 43.11323  ? 197 TRP A NE1 1 
ATOM   1549 C  CE2 . TRP A 1 199 ? -18.54424 33.09407 -54.24929 1.000 41.93280  ? 197 TRP A CE2 1 
ATOM   1550 C  CE3 . TRP A 1 199 ? -17.92473 31.08852 -53.03179 1.000 39.39583  ? 197 TRP A CE3 1 
ATOM   1551 C  CZ2 . TRP A 1 199 ? -17.21659 33.33025 -54.63990 1.000 41.07695  ? 197 TRP A CZ2 1 
ATOM   1552 C  CZ3 . TRP A 1 199 ? -16.60371 31.32828 -53.40994 1.000 42.80550  ? 197 TRP A CZ3 1 
ATOM   1553 C  CH2 . TRP A 1 199 ? -16.26236 32.43939 -54.20708 1.000 40.09822  ? 197 TRP A CH2 1 
ATOM   1554 N  N   . LYS A 1 200 ? -19.90313 28.40897 -53.37022 1.000 37.72091  ? 198 LYS A N   1 
ATOM   1555 C  CA  . LYS A 1 200 ? -18.74934 27.66490 -53.85946 1.000 41.04934  ? 198 LYS A CA  1 
ATOM   1556 C  C   . LYS A 1 200 ? -19.11006 26.85507 -55.09648 1.000 41.21947  ? 198 LYS A C   1 
ATOM   1557 O  O   . LYS A 1 200 ? -18.36540 26.85181 -56.08624 1.000 45.91712  ? 198 LYS A O   1 
ATOM   1558 C  CB  . LYS A 1 200 ? -18.21164 26.77219 -52.73535 1.000 42.69675  ? 198 LYS A CB  1 
ATOM   1559 C  CG  . LYS A 1 200 ? -17.22446 27.49850 -51.80626 1.000 49.56314  ? 198 LYS A CG  1 
ATOM   1560 C  CD  . LYS A 1 200 ? -17.39330 27.07451 -50.34774 1.000 53.49541  ? 198 LYS A CD  1 
ATOM   1561 C  CE  . LYS A 1 200 ? -16.36739 26.04899 -49.87562 1.000 61.79960  ? 198 LYS A CE  1 
ATOM   1562 N  NZ  . LYS A 1 200 ? -15.06750 26.66771 -49.45748 1.000 74.11146  ? 198 LYS A NZ  1 
ATOM   1563 N  N   . GLN A 1 201 ? -20.27438 26.20442 -55.08345 1.000 37.28532  ? 199 GLN A N   1 
ATOM   1564 C  CA  . GLN A 1 201 ? -20.67442 25.42513 -56.24588 1.000 37.02294  ? 199 GLN A CA  1 
ATOM   1565 C  C   . GLN A 1 201 ? -20.94579 26.30064 -57.46448 1.000 43.01233  ? 199 GLN A C   1 
ATOM   1566 O  O   . GLN A 1 201 ? -20.60731 25.91803 -58.59177 1.000 37.67593  ? 199 GLN A O   1 
ATOM   1567 C  CB  . GLN A 1 201 ? -21.89248 24.56221 -55.93067 1.000 46.49902  ? 199 GLN A CB  1 
ATOM   1568 C  CG  . GLN A 1 201 ? -21.59381 23.42514 -54.96978 1.000 49.13416  ? 199 GLN A CG  1 
ATOM   1569 C  CD  . GLN A 1 201 ? -20.35890 22.63697 -55.43866 1.000 67.45681  ? 199 GLN A CD  1 
ATOM   1570 O  OE1 . GLN A 1 201 ? -19.42900 22.41457 -54.65683 1.000 68.72370  ? 199 GLN A OE1 1 
ATOM   1571 N  NE2 . GLN A 1 201 ? -20.28477 22.34738 -56.75027 1.000 62.91814  ? 199 GLN A NE2 1 
ATOM   1572 N  N   . HIS A 1 202 ? -21.57775 27.46252 -57.28253 1.000 41.04739  ? 200 HIS A N   1 
ATOM   1573 C  CA  . HIS A 1 202 ? -21.83677 28.29596 -58.45592 1.000 43.24805  ? 200 HIS A CA  1 
ATOM   1574 C  C   . HIS A 1 202 ? -20.55795 28.95385 -58.95992 1.000 40.51829  ? 200 HIS A C   1 
ATOM   1575 O  O   . HIS A 1 202 ? -20.41956 29.19692 -60.16080 1.000 37.57267  ? 200 HIS A O   1 
ATOM   1576 C  CB  . HIS A 1 202 ? -22.89930 29.35813 -58.14475 1.000 44.00760  ? 200 HIS A CB  1 
ATOM   1577 C  CG  . HIS A 1 202 ? -24.29306 28.81297 -58.11118 1.000 51.25368  ? 200 HIS A CG  1 
ATOM   1578 N  ND1 . HIS A 1 202 ? -25.01102 28.53299 -59.25555 1.000 57.01837  ? 200 HIS A ND1 1 
ATOM   1579 C  CD2 . HIS A 1 202 ? -25.08885 28.46188 -57.07315 1.000 44.73832  ? 200 HIS A CD2 1 
ATOM   1580 C  CE1 . HIS A 1 202 ? -26.19541 28.05002 -58.92428 1.000 49.99254  ? 200 HIS A CE1 1 
ATOM   1581 N  NE2 . HIS A 1 202 ? -26.26696 27.99276 -57.60790 1.000 50.57645  ? 200 HIS A NE2 1 
ATOM   1582 N  N   . HIS A 1 203 ? -19.63680 29.27942 -58.05372 1.000 36.69529  ? 201 HIS A N   1 
ATOM   1583 C  CA  . HIS A 1 203 ? -18.33776 29.78111 -58.46607 1.000 40.62858  ? 201 HIS A CA  1 
ATOM   1584 C  C   . HIS A 1 203 ? -17.60912 28.73695 -59.31183 1.000 44.01761  ? 201 HIS A C   1 
ATOM   1585 O  O   . HIS A 1 203 ? -17.04177 29.06761 -60.35687 1.000 40.54137  ? 201 HIS A O   1 
ATOM   1586 C  CB  . HIS A 1 203 ? -17.52622 30.18402 -57.22324 1.000 37.33082  ? 201 HIS A CB  1 
ATOM   1587 C  CG  . HIS A 1 203 ? -16.12884 30.65603 -57.51963 1.000 43.39008  ? 201 HIS A CG  1 
ATOM   1588 N  ND1 . HIS A 1 203 ? -15.01396 29.86908 -57.30984 1.000 41.98977  ? 201 HIS A ND1 1 
ATOM   1589 C  CD2 . HIS A 1 203 ? -15.66480 31.83865 -57.99088 1.000 42.60553  ? 201 HIS A CD2 1 
ATOM   1590 C  CE1 . HIS A 1 203 ? -13.92697 30.55004 -57.63019 1.000 42.67487  ? 201 HIS A CE1 1 
ATOM   1591 N  NE2 . HIS A 1 203 ? -14.29280 31.74370 -58.05578 1.000 44.20373  ? 201 HIS A NE2 1 
ATOM   1592 N  N   . LEU A 1 204 ? -17.66898 27.46389 -58.90340 1.000 40.69796  ? 202 LEU A N   1 
ATOM   1593 C  CA  . LEU A 1 204 ? -17.09975 26.37938 -59.70514 1.000 43.91416  ? 202 LEU A CA  1 
ATOM   1594 C  C   . LEU A 1 204 ? -17.71595 26.32717 -61.09699 1.000 47.56231  ? 202 LEU A C   1 
ATOM   1595 O  O   . LEU A 1 204 ? -16.99556 26.28066 -62.10154 1.000 48.89571  ? 202 LEU A O   1 
ATOM   1596 C  CB  . LEU A 1 204 ? -17.30498 25.03563 -59.00825 1.000 45.87384  ? 202 LEU A CB  1 
ATOM   1597 C  CG  . LEU A 1 204 ? -16.12042 24.27946 -58.42996 1.000 60.09165  ? 202 LEU A CG  1 
ATOM   1598 C  CD1 . LEU A 1 204 ? -16.60855 22.93279 -57.94130 1.000 56.42357  ? 202 LEU A CD1 1 
ATOM   1599 C  CD2 . LEU A 1 204 ? -15.02355 24.11616 -59.47809 1.000 64.36307  ? 202 LEU A CD2 1 
ATOM   1600 N  N   . ILE A 1 205 ? -19.05361 26.30419 -61.17731 1.000 44.64399  ? 203 ILE A N   1 
ATOM   1601 C  CA  . ILE A 1 205 ? -19.71468 26.26414 -62.47998 1.000 45.72262  ? 203 ILE A CA  1 
ATOM   1602 C  C   . ILE A 1 205 ? -19.24117 27.42485 -63.33288 1.000 46.71516  ? 203 ILE A C   1 
ATOM   1603 O  O   . ILE A 1 205 ? -19.07305 27.30125 -64.55371 1.000 43.73770  ? 203 ILE A O   1 
ATOM   1604 C  CB  . ILE A 1 205 ? -21.24947 26.27474 -62.32146 1.000 42.13173  ? 203 ILE A CB  1 
ATOM   1605 C  CG1 . ILE A 1 205 ? -21.73248 24.95582 -61.72980 1.000 45.10855  ? 203 ILE A CG1 1 
ATOM   1606 C  CG2 . ILE A 1 205 ? -21.93299 26.50365 -63.68059 1.000 41.56194  ? 203 ILE A CG2 1 
ATOM   1607 C  CD1 . ILE A 1 205 ? -23.15379 24.97462 -61.29192 1.000 41.47142  ? 203 ILE A CD1 1 
ATOM   1608 N  N   . MET A 1 206 ? -19.01951 28.57425 -62.69728 1.000 45.97135  ? 204 MET A N   1 
ATOM   1609 C  CA  . MET A 1 206 ? -18.56617 29.75655 -63.41783 1.000 43.28894  ? 204 MET A CA  1 
ATOM   1610 C  C   . MET A 1 206 ? -17.14967 29.54854 -63.95108 1.000 49.28384  ? 204 MET A C   1 
ATOM   1611 O  O   . MET A 1 206 ? -16.86966 29.81644 -65.12571 1.000 47.72633  ? 204 MET A O   1 
ATOM   1612 C  CB  . MET A 1 206 ? -18.65656 30.96301 -62.48523 1.000 42.73701  ? 204 MET A CB  1 
ATOM   1613 C  CG  . MET A 1 206 ? -18.36006 32.32597 -63.09356 1.000 43.51785  ? 204 MET A CG  1 
ATOM   1614 S  SD  . MET A 1 206 ? -16.60187 32.68190 -63.02622 1.000 56.49323  ? 204 MET A SD  1 
ATOM   1615 C  CE  . MET A 1 206 ? -16.35229 32.62303 -61.25376 1.000 50.23225  ? 204 MET A CE  1 
ATOM   1616 N  N   . VAL A 1 207 ? -16.25455 29.02777 -63.10617 1.000 42.37938  ? 205 VAL A N   1 
ATOM   1617 C  CA  . VAL A 1 207 ? -14.88470 28.77629 -63.53018 1.000 45.89038  ? 205 VAL A CA  1 
ATOM   1618 C  C   . VAL A 1 207 ? -14.85422 27.78348 -64.68958 1.000 46.53764  ? 205 VAL A C   1 
ATOM   1619 O  O   . VAL A 1 207 ? -14.10963 27.96979 -65.65617 1.000 50.42354  ? 205 VAL A O   1 
ATOM   1620 C  CB  . VAL A 1 207 ? -14.03817 28.30365 -62.33307 1.000 46.56360  ? 205 VAL A CB  1 
ATOM   1621 C  CG1 . VAL A 1 207 ? -12.69340 27.75985 -62.80646 1.000 45.08755  ? 205 VAL A CG1 1 
ATOM   1622 C  CG2 . VAL A 1 207 ? -13.82929 29.45785 -61.35921 1.000 41.26320  ? 205 VAL A CG2 1 
ATOM   1623 N  N   . TRP A 1 208 ? -15.68579 26.73836 -64.63716 1.000 44.66311  ? 206 TRP A N   1 
ATOM   1624 C  CA  . TRP A 1 208 ? -15.70152 25.76798 -65.72728 1.000 47.39663  ? 206 TRP A CA  1 
ATOM   1625 C  C   . TRP A 1 208 ? -16.06476 26.42078 -67.04653 1.000 53.70248  ? 206 TRP A C   1 
ATOM   1626 O  O   . TRP A 1 208 ? -15.53923 26.04140 -68.09899 1.000 59.87490  ? 206 TRP A O   1 
ATOM   1627 C  CB  . TRP A 1 208 ? -16.67544 24.63690 -65.43396 1.000 47.12109  ? 206 TRP A CB  1 
ATOM   1628 C  CG  . TRP A 1 208 ? -16.23701 23.81072 -64.30488 1.000 51.40747  ? 206 TRP A CG  1 
ATOM   1629 C  CD1 . TRP A 1 208 ? -14.96077 23.68441 -63.82081 1.000 53.54998  ? 206 TRP A CD1 1 
ATOM   1630 C  CD2 . TRP A 1 208 ? -17.06286 22.99841 -63.48393 1.000 50.42108  ? 206 TRP A CD2 1 
ATOM   1631 N  NE1 . TRP A 1 208 ? -14.94797 22.82931 -62.74575 1.000 56.48807  ? 206 TRP A NE1 1 
ATOM   1632 C  CE2 . TRP A 1 208 ? -16.22750 22.39262 -62.51947 1.000 58.16353  ? 206 TRP A CE2 1 
ATOM   1633 C  CE3 . TRP A 1 208 ? -18.43021 22.71199 -63.47136 1.000 52.15372  ? 206 TRP A CE3 1 
ATOM   1634 C  CZ2 . TRP A 1 208 ? -16.72103 21.52375 -61.54992 1.000 64.03609  ? 206 TRP A CZ2 1 
ATOM   1635 C  CZ3 . TRP A 1 208 ? -18.91563 21.84679 -62.51333 1.000 52.97854  ? 206 TRP A CZ3 1 
ATOM   1636 C  CH2 . TRP A 1 208 ? -18.06504 21.25832 -61.56883 1.000 54.19035  ? 206 TRP A CH2 1 
ATOM   1637 N  N   . SER A 1 209 ? -16.96340 27.39887 -67.01808 1.000 49.65037  ? 207 SER A N   1 
ATOM   1638 C  CA  . SER A 1 209 ? -17.41773 27.99518 -68.26631 1.000 50.33415  ? 207 SER A CA  1 
ATOM   1639 C  C   . SER A 1 209 ? -16.45350 29.04788 -68.79785 1.000 53.66547  ? 207 SER A C   1 
ATOM   1640 O  O   . SER A 1 209 ? -16.63744 29.51527 -69.92376 1.000 52.71949  ? 207 SER A O   1 
ATOM   1641 C  CB  . SER A 1 209 ? -18.81355 28.60867 -68.07720 1.000 51.22524  ? 207 SER A CB  1 
ATOM   1642 O  OG  . SER A 1 209 ? -18.75329 29.85882 -67.38933 1.000 52.14613  ? 207 SER A OG  1 
ATOM   1643 N  N   . GLN A 1 210 ? -15.45088 29.44484 -68.01554 1.000 53.85796  ? 208 GLN A N   1 
ATOM   1644 C  CA  . GLN A 1 210 ? -14.51041 30.48498 -68.41321 1.000 54.11289  ? 208 GLN A CA  1 
ATOM   1645 C  C   . GLN A 1 210 ? -13.10155 29.96759 -68.63578 1.000 55.20826  ? 208 GLN A C   1 
ATOM   1646 O  O   . GLN A 1 210 ? -12.46098 30.33639 -69.61738 1.000 62.16740  ? 208 GLN A O   1 
ATOM   1647 C  CB  . GLN A 1 210 ? -14.48156 31.59358 -67.36128 1.000 52.93498  ? 208 GLN A CB  1 
ATOM   1648 C  CG  . GLN A 1 210 ? -15.85215 32.16465 -67.04956 1.000 56.33632  ? 208 GLN A CG  1 
ATOM   1649 C  CD  . GLN A 1 210 ? -16.29404 33.19386 -68.06853 1.000 55.71362  ? 208 GLN A CD  1 
ATOM   1650 O  OE1 . GLN A 1 210 ? -15.46455 33.77452 -68.75699 1.000 61.92558  ? 208 GLN A OE1 1 
ATOM   1651 N  NE2 . GLN A 1 210 ? -17.60120 33.44006 -68.15807 1.000 57.72428  ? 208 GLN A NE2 1 
ATOM   1652 N  N   . LEU A 1 211 ? -12.61453 29.10529 -67.75272 1.000 57.62782  ? 209 LEU A N   1 
ATOM   1653 C  CA  . LEU A 1 211 ? -11.28486 28.52703 -67.85347 1.000 60.26782  ? 209 LEU A CA  1 
ATOM   1654 C  C   . LEU A 1 211 ? -11.32136 27.06876 -68.29063 1.000 57.87038  ? 209 LEU A C   1 
ATOM   1655 O  O   . LEU A 1 211 ? -10.29253 26.39289 -68.24404 1.000 68.01333  ? 209 LEU A O   1 
ATOM   1656 C  CB  . LEU A 1 211 ? -10.55792 28.65438 -66.50870 1.000 50.39781  ? 209 LEU A CB  1 
ATOM   1657 C  CG  . LEU A 1 211 ? -10.32971 30.07098 -65.96897 1.000 54.63807  ? 209 LEU A CG  1 
ATOM   1658 C  CD1 . LEU A 1 211 ? -9.50902  30.06633 -64.67974 1.000 56.27154  ? 209 LEU A CD1 1 
ATOM   1659 C  CD2 . LEU A 1 211 ? -9.68582  30.97838 -67.01139 1.000 55.29818  ? 209 LEU A CD2 1 
ATOM   1660 N  N   . GLY A 1 212 ? -12.47082 26.56664 -68.70821 1.000 61.95261  ? 210 GLY A N   1 
ATOM   1661 C  CA  . GLY A 1 212 ? -12.58935 25.14231 -68.95739 1.000 61.80910  ? 210 GLY A CA  1 
ATOM   1662 C  C   . GLY A 1 212 ? -12.47552 24.34951 -67.66135 1.000 64.70901  ? 210 GLY A C   1 
ATOM   1663 O  O   . GLY A 1 212 ? -12.50600 24.89247 -66.55314 1.000 58.85128  ? 210 GLY A O   1 
ATOM   1664 N  N   . GLY A 1 213 ? -12.34237 23.03440 -67.82042 1.000 65.64519  ? 211 GLY A N   1 
ATOM   1665 C  CA  . GLY A 1 213 ? -12.07141 22.15722 -66.69955 1.000 64.78406  ? 211 GLY A CA  1 
ATOM   1666 C  C   . GLY A 1 213 ? -13.24247 21.35229 -66.18334 1.000 64.05505  ? 211 GLY A C   1 
ATOM   1667 O  O   . GLY A 1 213 ? -13.14375 20.78837 -65.08657 1.000 67.14260  ? 211 GLY A O   1 
ATOM   1668 N  N   . GLN A 1 214 ? -14.33540 21.26859 -66.93507 1.000 63.75524  ? 212 GLN A N   1 
ATOM   1669 C  CA  . GLN A 1 214 ? -15.51710 20.56453 -66.45884 1.000 65.45035  ? 212 GLN A CA  1 
ATOM   1670 C  C   . GLN A 1 214 ? -15.19467 19.09056 -66.21112 1.000 67.59720  ? 212 GLN A C   1 
ATOM   1671 O  O   . GLN A 1 214 ? -14.68557 18.41388 -67.11389 1.000 74.25560  ? 212 GLN A O   1 
ATOM   1672 C  CB  . GLN A 1 214 ? -16.65007 20.71430 -67.47271 1.000 66.40854  ? 212 GLN A CB  1 
ATOM   1673 C  CG  . GLN A 1 214 ? -18.01619 20.91388 -66.85250 1.000 58.86151  ? 212 GLN A CG  1 
ATOM   1674 C  CD  . GLN A 1 214 ? -18.71131 19.59936 -66.59693 1.000 62.81221  ? 212 GLN A CD  1 
ATOM   1675 O  OE1 . GLN A 1 214 ? -18.63965 18.68021 -67.41553 1.000 70.49658  ? 212 GLN A OE1 1 
ATOM   1676 N  NE2 . GLN A 1 214 ? -19.37826 19.49139 -65.45545 1.000 61.87675  ? 212 GLN A NE2 1 
ATOM   1677 N  N   . PRO A 1 215 ? -15.47847 18.56095 -65.01388 1.000 69.00557  ? 213 PRO A N   1 
ATOM   1678 C  CA  . PRO A 1 215 ? -15.05474 17.18606 -64.67436 1.000 69.14389  ? 213 PRO A CA  1 
ATOM   1679 C  C   . PRO A 1 215 ? -15.75927 16.08429 -65.45294 1.000 77.45345  ? 213 PRO A C   1 
ATOM   1680 O  O   . PRO A 1 215 ? -15.22938 14.96605 -65.50903 1.000 85.09891  ? 213 PRO A O   1 
ATOM   1681 C  CB  . PRO A 1 215 ? -15.38115 17.07489 -63.17616 1.000 71.52645  ? 213 PRO A CB  1 
ATOM   1682 C  CG  . PRO A 1 215 ? -15.52975 18.47201 -62.69784 1.000 72.89402  ? 213 PRO A CG  1 
ATOM   1683 C  CD  . PRO A 1 215 ? -16.07462 19.24933 -63.86276 1.000 71.76764  ? 213 PRO A CD  1 
ATOM   1684 N  N   . GLY A 1 216 ? -16.93433 16.33993 -66.02987 1.000 74.07966  ? 214 GLY A N   1 
ATOM   1685 C  CA  . GLY A 1 216 ? -17.58668 15.31787 -66.83571 1.000 74.78612  ? 214 GLY A CA  1 
ATOM   1686 C  C   . GLY A 1 216 ? -16.95735 15.08983 -68.19941 1.000 83.11746  ? 214 GLY A C   1 
ATOM   1687 O  O   . GLY A 1 216 ? -17.35371 14.14652 -68.89456 1.000 88.41945  ? 214 GLY A O   1 
ATOM   1688 N  N   . LEU A 1 217 ? -16.00353 15.93554 -68.60033 1.000 78.42941  ? 215 LEU A N   1 
ATOM   1689 C  CA  . LEU A 1 217 ? -15.30836 15.77443 -69.87346 1.000 86.69301  ? 215 LEU A CA  1 
ATOM   1690 C  C   . LEU A 1 217 ? -14.33212 14.60180 -69.86222 1.000 97.59168  ? 215 LEU A C   1 
ATOM   1691 O  O   . LEU A 1 217 ? -13.80158 14.24338 -70.92386 1.000 100.75515 ? 215 LEU A O   1 
ATOM   1692 C  CB  . LEU A 1 217 ? -14.59367 17.08022 -70.23709 1.000 79.26795  ? 215 LEU A CB  1 
ATOM   1693 C  CG  . LEU A 1 217 ? -15.57229 18.25151 -70.40021 1.000 71.41582  ? 215 LEU A CG  1 
ATOM   1694 C  CD1 . LEU A 1 217 ? -14.85713 19.56027 -70.73340 1.000 63.22674  ? 215 LEU A CD1 1 
ATOM   1695 C  CD2 . LEU A 1 217 ? -16.61162 17.89685 -71.46081 1.000 62.02248  ? 215 LEU A CD2 1 
ATOM   1696 N  N   . ARG A 1 218 ? -14.07538 14.01982 -68.69175 1.000 98.73064  ? 216 ARG A N   1 
ATOM   1697 C  CA  . ARG A 1 218 ? -13.54624 12.66401 -68.57627 1.000 109.31532 ? 216 ARG A CA  1 
ATOM   1698 C  C   . ARG A 1 218 ? -14.64186 11.78717 -67.96214 1.000 108.96969 ? 216 ARG A C   1 
ATOM   1699 O  O   . ARG A 1 218 ? -15.06268 10.78766 -68.55077 1.000 110.54793 ? 216 ARG A O   1 
ATOM   1700 C  CB  . ARG A 1 218 ? -12.26642 12.63409 -67.72852 1.000 110.05143 ? 216 ARG A CB  1 
ATOM   1701 C  CG  . ARG A 1 218 ? -12.16066 11.46940 -66.73279 1.000 114.14656 ? 216 ARG A CG  1 
ATOM   1702 C  CD  . ARG A 1 218 ? -12.00668 10.08564 -67.39594 1.000 119.71992 ? 216 ARG A CD  1 
ATOM   1703 N  NE  . ARG A 1 218 ? -12.31764 9.00644  -66.46053 1.000 121.09866 ? 216 ARG A NE  1 
ATOM   1704 C  CZ  . ARG A 1 218 ? -13.52615 8.48656  -66.27452 1.000 121.15776 ? 216 ARG A CZ  1 
ATOM   1705 N  NH1 . ARG A 1 218 ? -14.57293 8.89531  -66.97530 1.000 118.86802 ? 216 ARG A NH1 1 
ATOM   1706 N  NH2 . ARG A 1 218 ? -13.68973 7.53469  -65.35821 1.000 112.74414 ? 216 ARG A NH2 1 
ATOM   1707 N  N   . ARG A 1 237 ? -6.25274  28.17850 -63.23283 1.000 92.27128  ? 235 ARG A N   1 
ATOM   1708 C  CA  . ARG A 1 237 ? -5.80614  26.86593 -63.69517 1.000 105.88269 ? 235 ARG A CA  1 
ATOM   1709 C  C   . ARG A 1 237 ? -5.26148  26.02797 -62.53059 1.000 112.50085 ? 235 ARG A C   1 
ATOM   1710 O  O   . ARG A 1 237 ? -4.50438  25.06355 -62.73693 1.000 110.51977 ? 235 ARG A O   1 
ATOM   1711 C  CB  . ARG A 1 237 ? -4.74410  27.00346 -64.79932 1.000 101.22790 ? 235 ARG A CB  1 
ATOM   1712 C  CG  . ARG A 1 237 ? -4.85454  25.94739 -65.90606 1.000 99.02505  ? 235 ARG A CG  1 
ATOM   1713 C  CD  . ARG A 1 237 ? -6.32406  25.64813 -66.24693 1.000 97.66072  ? 235 ARG A CD  1 
ATOM   1714 N  NE  . ARG A 1 237 ? -6.47493  24.46057 -67.08585 1.000 100.92074 ? 235 ARG A NE  1 
ATOM   1715 C  CZ  . ARG A 1 237 ? -7.62880  24.03740 -67.58903 1.000 91.18002  ? 235 ARG A CZ  1 
ATOM   1716 N  NH1 . ARG A 1 237 ? -8.75894  24.68441 -67.36134 1.000 87.15718  ? 235 ARG A NH1 1 
ATOM   1717 N  NH2 . ARG A 1 237 ? -7.65005  22.93583 -68.33772 1.000 86.21721  ? 235 ARG A NH2 1 
ATOM   1718 N  N   . SER A 1 238 ? -5.64698  26.40753 -61.31439 1.000 102.45973 ? 236 SER A N   1 
ATOM   1719 C  CA  . SER A 1 238 ? -5.36741  25.62480 -60.10688 1.000 99.80463  ? 236 SER A CA  1 
ATOM   1720 C  C   . SER A 1 238 ? -6.58038  24.78152 -59.72842 1.000 96.61819  ? 236 SER A C   1 
ATOM   1721 O  O   . SER A 1 238 ? -7.02323  24.75465 -58.57690 1.000 94.60355  ? 236 SER A O   1 
ATOM   1722 C  CB  . SER A 1 238 ? -4.95646  26.54805 -58.96233 1.000 102.23355 ? 236 SER A CB  1 
ATOM   1723 O  OG  . SER A 1 238 ? -6.08228  27.09167 -58.28317 1.000 92.02656  ? 236 SER A OG  1 
ATOM   1724 N  N   . LEU A 1 239 ? -7.11578  24.06382 -60.71970 1.000 89.93899  ? 237 LEU A N   1 
ATOM   1725 C  CA  . LEU A 1 239 ? -8.49180  23.58615 -60.63489 1.000 84.81728  ? 237 LEU A CA  1 
ATOM   1726 C  C   . LEU A 1 239 ? -8.66874  22.52889 -59.55051 1.000 86.15428  ? 237 LEU A C   1 
ATOM   1727 O  O   . LEU A 1 239 ? -9.66394  22.55760 -58.81774 1.000 86.25032  ? 237 LEU A O   1 
ATOM   1728 C  CB  . LEU A 1 239 ? -8.94622  23.04454 -61.99127 1.000 86.80680  ? 237 LEU A CB  1 
ATOM   1729 C  CG  . LEU A 1 239 ? -9.85645  23.92406 -62.85831 1.000 81.81828  ? 237 LEU A CG  1 
ATOM   1730 C  CD1 . LEU A 1 239 ? -11.28166 23.85673 -62.34480 1.000 79.43919  ? 237 LEU A CD1 1 
ATOM   1731 C  CD2 . LEU A 1 239 ? -9.37091  25.36863 -62.92835 1.000 80.41068  ? 237 LEU A CD2 1 
ATOM   1732 N  N   . ALA A 1 240 ? -7.72480  21.59103 -59.42306 1.000 81.39423  ? 238 ALA A N   1 
ATOM   1733 C  CA  . ALA A 1 240 ? -7.95458  20.44783 -58.53952 1.000 78.44601  ? 238 ALA A CA  1 
ATOM   1734 C  C   . ALA A 1 240 ? -8.10942  20.88280 -57.08648 1.000 74.71795  ? 238 ALA A C   1 
ATOM   1735 O  O   . ALA A 1 240 ? -8.90778  20.30378 -56.33874 1.000 67.31560  ? 238 ALA A O   1 
ATOM   1736 C  CB  . ALA A 1 240 ? -6.81982  19.43469 -58.67811 1.000 80.93090  ? 238 ALA A CB  1 
ATOM   1737 N  N   . THR A 1 241 ? -7.34430  21.89431 -56.66700 1.000 76.90940  ? 239 THR A N   1 
ATOM   1738 C  CA  . THR A 1 241 ? -7.50893  22.44367 -55.32619 1.000 79.63048  ? 239 THR A CA  1 
ATOM   1739 C  C   . THR A 1 241 ? -8.86977  23.11630 -55.17799 1.000 77.86372  ? 239 THR A C   1 
ATOM   1740 O  O   . THR A 1 241 ? -9.54372  22.94827 -54.15131 1.000 69.73507  ? 239 THR A O   1 
ATOM   1741 C  CB  . THR A 1 241 ? -6.38312  23.43970 -55.02407 1.000 83.26748  ? 239 THR A CB  1 
ATOM   1742 O  OG1 . THR A 1 241 ? -5.17736  23.00291 -55.65798 1.000 86.37108  ? 239 THR A OG1 1 
ATOM   1743 C  CG2 . THR A 1 241 ? -6.14260  23.56575 -53.51439 1.000 82.16077  ? 239 THR A CG2 1 
ATOM   1744 N  N   . LEU A 1 242 ? -9.28651  23.87593 -56.20155 1.000 74.15887  ? 240 LEU A N   1 
ATOM   1745 C  CA  . LEU A 1 242 ? -10.56601 24.57408 -56.15541 1.000 67.11132  ? 240 LEU A CA  1 
ATOM   1746 C  C   . LEU A 1 242 ? -11.72634 23.60418 -55.95683 1.000 67.61305  ? 240 LEU A C   1 
ATOM   1747 O  O   . LEU A 1 242 ? -12.61968 23.86312 -55.13940 1.000 62.25789  ? 240 LEU A O   1 
ATOM   1748 C  CB  . LEU A 1 242 ? -10.76086 25.40222 -57.42485 1.000 63.44025  ? 240 LEU A CB  1 
ATOM   1749 C  CG  . LEU A 1 242 ? -11.93608 26.39393 -57.40422 1.000 60.62499  ? 240 LEU A CG  1 
ATOM   1750 C  CD1 . LEU A 1 242 ? -11.79755 27.44181 -56.30497 1.000 54.28654  ? 240 LEU A CD1 1 
ATOM   1751 C  CD2 . LEU A 1 242 ? -12.08762 27.05971 -58.76045 1.000 57.69272  ? 240 LEU A CD2 1 
ATOM   1752 N  N   . GLU A 1 243 ? -11.72860 22.47417 -56.67629 1.000 63.34160  ? 241 GLU A N   1 
ATOM   1753 C  CA  . GLU A 1 243 ? -12.81498 21.51544 -56.49144 1.000 64.49636  ? 241 GLU A CA  1 
ATOM   1754 C  C   . GLU A 1 243 ? -12.79193 20.92099 -55.09344 1.000 64.05775  ? 241 GLU A C   1 
ATOM   1755 O  O   . GLU A 1 243 ? -13.84435 20.72871 -54.47678 1.000 66.10452  ? 241 GLU A O   1 
ATOM   1756 C  CB  . GLU A 1 243 ? -12.77995 20.39524 -57.53439 1.000 64.05138  ? 241 GLU A CB  1 
ATOM   1757 C  CG  . GLU A 1 243 ? -13.38933 20.75730 -58.89232 1.000 76.39819  ? 241 GLU A CG  1 
ATOM   1758 C  CD  . GLU A 1 243 ? -12.35837 20.82938 -60.01774 1.000 89.95853  ? 241 GLU A CD  1 
ATOM   1759 O  OE1 . GLU A 1 243 ? -12.73596 21.19110 -61.16535 1.000 76.00135  ? 241 GLU A OE1 1 
ATOM   1760 O  OE2 . GLU A 1 243 ? -11.18356 20.46548 -59.76249 1.000 91.75718  ? 241 GLU A OE2 1 
ATOM   1761 N  N   . ALA A 1 244 ? -11.60763 20.62010 -54.57118 1.000 64.00700  ? 242 ALA A N   1 
ATOM   1762 C  CA  . ALA A 1 244 ? -11.55692 20.03495 -53.23908 1.000 64.53807  ? 242 ALA A CA  1 
ATOM   1763 C  C   . ALA A 1 244 ? -11.89233 21.07407 -52.17770 1.000 62.93638  ? 242 ALA A C   1 
ATOM   1764 O  O   . ALA A 1 244 ? -12.53385 20.76003 -51.16828 1.000 63.99287  ? 242 ALA A O   1 
ATOM   1765 C  CB  . ALA A 1 244 ? -10.18279 19.41734 -52.99097 1.000 65.89807  ? 242 ALA A CB  1 
ATOM   1766 N  N   . ARG A 1 245 ? -11.47057 22.31921 -52.39481 1.000 62.38722  ? 243 ARG A N   1 
ATOM   1767 C  CA  . ARG A 1 245 ? -11.81132 23.39443 -51.47257 1.000 63.42852  ? 243 ARG A CA  1 
ATOM   1768 C  C   . ARG A 1 245 ? -13.31865 23.64116 -51.44295 1.000 62.17711  ? 243 ARG A C   1 
ATOM   1769 O  O   . ARG A 1 245 ? -13.87414 23.94519 -50.38451 1.000 57.76650  ? 243 ARG A O   1 
ATOM   1770 C  CB  . ARG A 1 245 ? -11.05146 24.65817 -51.88237 1.000 69.65678  ? 243 ARG A CB  1 
ATOM   1771 C  CG  . ARG A 1 245 ? -9.65838  24.77036 -51.27569 1.000 63.69676  ? 243 ARG A CG  1 
ATOM   1772 C  CD  . ARG A 1 245 ? -8.91534  26.01073 -51.78080 1.000 69.95883  ? 243 ARG A CD  1 
ATOM   1773 N  NE  . ARG A 1 245 ? -8.10972  26.62207 -50.72757 1.000 83.67721  ? 243 ARG A NE  1 
ATOM   1774 C  CZ  . ARG A 1 245 ? -8.57059  27.02832 -49.54519 1.000 94.89864  ? 243 ARG A CZ  1 
ATOM   1775 N  NH1 . ARG A 1 245 ? -9.86842  27.01992 -49.25531 1.000 88.11713  ? 243 ARG A NH1 1 
ATOM   1776 N  NH2 . ARG A 1 245 ? -7.70761  27.46161 -48.62689 1.000 98.07332  ? 243 ARG A NH2 1 
ATOM   1777 N  N   . SER A 1 246 ? -14.00140 23.46154 -52.58255 1.000 61.00908  ? 244 SER A N   1 
ATOM   1778 C  CA  . SER A 1 246 ? -15.42568 23.73627 -52.75094 1.000 56.82061  ? 244 SER A CA  1 
ATOM   1779 C  C   . SER A 1 246 ? -16.32291 22.83333 -51.91581 1.000 65.52801  ? 244 SER A C   1 
ATOM   1780 O  O   . SER A 1 246 ? -17.54858 23.00747 -51.94796 1.000 63.57858  ? 244 SER A O   1 
ATOM   1781 C  CB  . SER A 1 246 ? -15.81526 23.60969 -54.23067 1.000 62.46129  ? 244 SER A CB  1 
ATOM   1782 O  OG  . SER A 1 246 ? -16.34788 22.32173 -54.53886 1.000 62.54624  ? 244 SER A OG  1 
ATOM   1783 N  N   . GLN A 1 247 ? -15.77186 21.87534 -51.18127 1.000 62.67747  ? 245 GLN A N   1 
ATOM   1784 C  CA  . GLN A 1 247 ? -16.59647 20.97218 -50.39954 1.000 65.04397  ? 245 GLN A CA  1 
ATOM   1785 C  C   . GLN A 1 247 ? -16.40377 21.14050 -48.90541 1.000 56.65430  ? 245 GLN A C   1 
ATOM   1786 O  O   . GLN A 1 247 ? -17.00499 20.39265 -48.13746 1.000 57.48398  ? 245 GLN A O   1 
ATOM   1787 C  CB  . GLN A 1 247 ? -16.33054 19.51943 -50.80291 1.000 64.49145  ? 245 GLN A CB  1 
ATOM   1788 C  CG  . GLN A 1 247 ? -17.34302 18.99196 -51.81989 1.000 77.20341  ? 245 GLN A CG  1 
ATOM   1789 C  CD  . GLN A 1 247 ? -16.80543 17.82375 -52.63198 1.000 90.42817  ? 245 GLN A CD  1 
ATOM   1790 O  OE1 . GLN A 1 247 ? -15.67150 17.37102 -52.41532 1.000 86.09332  ? 245 GLN A OE1 1 
ATOM   1791 N  NE2 . GLN A 1 247 ? -17.62526 17.31444 -53.56187 1.000 80.54438  ? 245 GLN A NE2 1 
ATOM   1792 N  N   . LEU A 1 248 ? -15.59850 22.10491 -48.47452 1.000 54.21919  ? 246 LEU A N   1 
ATOM   1793 C  CA  . LEU A 1 248 ? -15.41080 22.35370 -47.05411 1.000 63.23015  ? 246 LEU A CA  1 
ATOM   1794 C  C   . LEU A 1 248 ? -16.53367 23.22575 -46.51393 1.000 61.84801  ? 246 LEU A C   1 
ATOM   1795 O  O   . LEU A 1 248 ? -16.79364 24.31427 -47.03546 1.000 60.88755  ? 246 LEU A O   1 
ATOM   1796 C  CB  . LEU A 1 248 ? -14.06450 23.02424 -46.79768 1.000 65.38396  ? 246 LEU A CB  1 
ATOM   1797 C  CG  . LEU A 1 248 ? -12.86594 22.44196 -47.53543 1.000 72.65160  ? 246 LEU A CG  1 
ATOM   1798 C  CD1 . LEU A 1 248 ? -11.69541 23.43582 -47.52172 1.000 61.18622  ? 246 LEU A CD1 1 
ATOM   1799 C  CD2 . LEU A 1 248 ? -12.49902 21.11752 -46.88503 1.000 58.65526  ? 246 LEU A CD2 1 
ATOM   1800 N  N   . ALA A 1 249 ? -17.18341 22.75195 -45.45920 1.000 56.72818  ? 247 ALA A N   1 
ATOM   1801 C  CA  . ALA A 1 249 ? -18.25795 23.50029 -44.83277 1.000 57.64926  ? 247 ALA A CA  1 
ATOM   1802 C  C   . ALA A 1 249 ? -17.69099 24.51116 -43.83433 1.000 57.71625  ? 247 ALA A C   1 
ATOM   1803 O  O   . ALA A 1 249 ? -16.53112 24.43396 -43.42778 1.000 59.95869  ? 247 ALA A O   1 
ATOM   1804 C  CB  . ALA A 1 249 ? -19.23396 22.54161 -44.14567 1.000 48.37261  ? 247 ALA A CB  1 
ATOM   1805 N  N   . LEU A 1 250 ? -18.52672 25.48476 -43.45408 1.000 57.07028  ? 248 LEU A N   1 
ATOM   1806 C  CA  . LEU A 1 250 ? -18.15321 26.39834 -42.37749 1.000 52.50774  ? 248 LEU A CA  1 
ATOM   1807 C  C   . LEU A 1 250 ? -18.25958 25.72189 -41.01974 1.000 50.63664  ? 248 LEU A C   1 
ATOM   1808 O  O   . LEU A 1 250 ? -17.47379 26.01368 -40.11050 1.000 58.14106  ? 248 LEU A O   1 
ATOM   1809 C  CB  . LEU A 1 250 ? -19.04812 27.63380 -42.39915 1.000 56.32810  ? 248 LEU A CB  1 
ATOM   1810 C  CG  . LEU A 1 250 ? -18.85610 28.75789 -43.40310 1.000 51.74613  ? 248 LEU A CG  1 
ATOM   1811 C  CD1 . LEU A 1 250 ? -19.96745 29.75474 -43.18230 1.000 56.33817  ? 248 LEU A CD1 1 
ATOM   1812 C  CD2 . LEU A 1 250 ? -17.51522 29.42227 -43.20157 1.000 55.77794  ? 248 LEU A CD2 1 
ATOM   1813 N  N   . PHE A 1 251 ? -19.25117 24.84571 -40.85356 1.000 50.21803  ? 249 PHE A N   1 
ATOM   1814 C  CA  . PHE A 1 251 ? -19.53528 24.17382 -39.58398 1.000 50.27678  ? 249 PHE A CA  1 
ATOM   1815 C  C   . PHE A 1 251 ? -19.57122 22.66992 -39.81443 1.000 48.78583  ? 249 PHE A C   1 
ATOM   1816 O  O   . PHE A 1 251 ? -20.64459 22.05191 -39.80990 1.000 50.60351  ? 249 PHE A O   1 
ATOM   1817 C  CB  . PHE A 1 251 ? -20.85869 24.65935 -38.98293 1.000 45.52238  ? 249 PHE A CB  1 
ATOM   1818 C  CG  . PHE A 1 251 ? -21.02291 26.15487 -38.98835 1.000 50.98590  ? 249 PHE A CG  1 
ATOM   1819 C  CD1 . PHE A 1 251 ? -20.08862 26.97715 -38.35663 1.000 51.02000  ? 249 PHE A CD1 1 
ATOM   1820 C  CD2 . PHE A 1 251 ? -22.10906 26.74544 -39.62612 1.000 46.24228  ? 249 PHE A CD2 1 
ATOM   1821 C  CE1 . PHE A 1 251 ? -20.23645 28.37252 -38.35884 1.000 48.18122  ? 249 PHE A CE1 1 
ATOM   1822 C  CE2 . PHE A 1 251 ? -22.26223 28.13605 -39.63744 1.000 49.76668  ? 249 PHE A CE2 1 
ATOM   1823 C  CZ  . PHE A 1 251 ? -21.32804 28.95234 -38.99329 1.000 44.23559  ? 249 PHE A CZ  1 
ATOM   1824 N  N   . PRO A 1 252 ? -18.40794 22.04055 -40.00168 1.000 58.20501  ? 250 PRO A N   1 
ATOM   1825 C  CA  . PRO A 1 252 ? -18.40293 20.60515 -40.33946 1.000 47.24878  ? 250 PRO A CA  1 
ATOM   1826 C  C   . PRO A 1 252 ? -19.07403 19.73930 -39.30055 1.000 51.83789  ? 250 PRO A C   1 
ATOM   1827 O  O   . PRO A 1 252 ? -19.60227 18.67306 -39.64302 1.000 58.61577  ? 250 PRO A O   1 
ATOM   1828 C  CB  . PRO A 1 252 ? -16.90945 20.28096 -40.46059 1.000 52.29748  ? 250 PRO A CB  1 
ATOM   1829 C  CG  . PRO A 1 252 ? -16.25098 21.59008 -40.70270 1.000 49.87176  ? 250 PRO A CG  1 
ATOM   1830 C  CD  . PRO A 1 252 ? -17.04538 22.58646 -39.91194 1.000 55.12796  ? 250 PRO A CD  1 
ATOM   1831 N  N   . GLU A 1 253 ? -19.09064 20.17754 -38.04111 1.000 46.71572  ? 251 GLU A N   1 
ATOM   1832 C  CA  . GLU A 1 253 ? -19.75091 19.41744 -36.98553 1.000 51.64307  ? 251 GLU A CA  1 
ATOM   1833 C  C   . GLU A 1 253 ? -21.24021 19.23944 -37.23869 1.000 56.01528  ? 251 GLU A C   1 
ATOM   1834 O  O   . GLU A 1 253 ? -21.81415 18.21394 -36.85081 1.000 55.51231  ? 251 GLU A O   1 
ATOM   1835 C  CB  . GLU A 1 253 ? -19.54072 20.11448 -35.64837 1.000 60.65775  ? 251 GLU A CB  1 
ATOM   1836 C  CG  . GLU A 1 253 ? -18.08148 20.27691 -35.24886 1.000 64.60356  ? 251 GLU A CG  1 
ATOM   1837 C  CD  . GLU A 1 253 ? -17.39274 21.47342 -35.92394 1.000 82.28389  ? 251 GLU A CD  1 
ATOM   1838 O  OE1 . GLU A 1 253 ? -18.07650 22.27147 -36.63067 1.000 77.15237  ? 251 GLU A OE1 1 
ATOM   1839 O  OE2 . GLU A 1 253 ? -16.16035 21.62729 -35.71019 1.000 84.72012  ? 251 GLU A OE2 1 
ATOM   1840 N  N   . LEU A 1 254 ? -21.89554 20.23243 -37.84911 1.000 54.89602  ? 252 LEU A N   1 
ATOM   1841 C  CA  . LEU A 1 254 ? -23.32365 20.09524 -38.12247 1.000 49.43163  ? 252 LEU A CA  1 
ATOM   1842 C  C   . LEU A 1 254 ? -23.57118 19.01660 -39.15875 1.000 47.82698  ? 252 LEU A C   1 
ATOM   1843 O  O   . LEU A 1 254 ? -24.56414 18.28715 -39.08304 1.000 54.46291  ? 252 LEU A O   1 
ATOM   1844 C  CB  . LEU A 1 254 ? -23.90514 21.42530 -38.59673 1.000 52.42148  ? 252 LEU A CB  1 
ATOM   1845 C  CG  . LEU A 1 254 ? -23.99842 22.55649 -37.57959 1.000 57.36045  ? 252 LEU A CG  1 
ATOM   1846 C  CD1 . LEU A 1 254 ? -24.72111 23.72612 -38.20078 1.000 56.31611  ? 252 LEU A CD1 1 
ATOM   1847 C  CD2 . LEU A 1 254 ? -24.70821 22.09310 -36.30497 1.000 57.40516  ? 252 LEU A CD2 1 
ATOM   1848 N  N   . TRP A 1 255 ? -22.67725 18.90205 -40.13385 1.000 47.82454  ? 253 TRP A N   1 
ATOM   1849 C  CA  . TRP A 1 255 ? -22.79869 17.84251 -41.12445 1.000 53.02225  ? 253 TRP A CA  1 
ATOM   1850 C  C   . TRP A 1 255 ? -22.42659 16.48838 -40.53446 1.000 57.06045  ? 253 TRP A C   1 
ATOM   1851 O  O   . TRP A 1 255 ? -23.03769 15.46946 -40.88433 1.000 58.50015  ? 253 TRP A O   1 
ATOM   1852 C  CB  . TRP A 1 255 ? -21.94430 18.18998 -42.33900 1.000 56.42817  ? 253 TRP A CB  1 
ATOM   1853 C  CG  . TRP A 1 255 ? -22.27661 19.56736 -42.84818 1.000 57.16725  ? 253 TRP A CG  1 
ATOM   1854 C  CD1 . TRP A 1 255 ? -21.70444 20.75128 -42.46239 1.000 55.21115  ? 253 TRP A CD1 1 
ATOM   1855 C  CD2 . TRP A 1 255 ? -23.28801 19.90547 -43.80467 1.000 52.36663  ? 253 TRP A CD2 1 
ATOM   1856 N  NE1 . TRP A 1 255 ? -22.28448 21.80193 -43.13492 1.000 51.96399  ? 253 TRP A NE1 1 
ATOM   1857 C  CE2 . TRP A 1 255 ? -23.25836 21.30974 -43.96643 1.000 58.71440  ? 253 TRP A CE2 1 
ATOM   1858 C  CE3 . TRP A 1 255 ? -24.21161 19.15827 -44.54625 1.000 51.82616  ? 253 TRP A CE3 1 
ATOM   1859 C  CZ2 . TRP A 1 255 ? -24.11826 21.97910 -44.84337 1.000 54.38303  ? 253 TRP A CZ2 1 
ATOM   1860 C  CZ3 . TRP A 1 255 ? -25.06214 19.82253 -45.41771 1.000 47.28797  ? 253 TRP A CZ3 1 
ATOM   1861 C  CH2 . TRP A 1 255 ? -25.00752 21.21674 -45.55883 1.000 50.72678  ? 253 TRP A CH2 1 
ATOM   1862 N  N   . ARG A 1 256 ? -21.42634 16.44589 -39.64504 1.000 54.51880  ? 254 ARG A N   1 
ATOM   1863 C  CA  A ARG A 1 256 ? -21.14361 15.22125 -38.89938 0.510 59.82417  ? 254 ARG A CA  1 
ATOM   1864 C  CA  B ARG A 1 256 ? -21.16680 15.19300 -38.94327 0.490 59.82922  ? 254 ARG A CA  1 
ATOM   1865 C  C   . ARG A 1 256 ? -22.37218 14.78954 -38.10829 1.000 59.14826  ? 254 ARG A C   1 
ATOM   1866 O  O   . ARG A 1 256 ? -22.77383 13.61838 -38.12501 1.000 58.61578  ? 254 ARG A O   1 
ATOM   1867 C  CB  A ARG A 1 256 ? -19.95027 15.45265 -37.96296 0.510 61.69710  ? 254 ARG A CB  1 
ATOM   1868 C  CB  B ARG A 1 256 ? -19.91324 15.28465 -38.06839 0.490 61.75210  ? 254 ARG A CB  1 
ATOM   1869 C  CG  A ARG A 1 256 ? -18.81940 14.42697 -38.04374 0.510 64.37299  ? 254 ARG A CG  1 
ATOM   1870 C  CG  B ARG A 1 256 ? -19.54210 13.94422 -37.40266 0.490 59.07550  ? 254 ARG A CG  1 
ATOM   1871 C  CD  A ARG A 1 256 ? -17.59772 14.87123 -37.21259 0.510 60.68677  ? 254 ARG A CD  1 
ATOM   1872 C  CD  B ARG A 1 256 ? -18.03395 13.67860 -37.41092 0.490 63.56481  ? 254 ARG A CD  1 
ATOM   1873 N  NE  A ARG A 1 256 ? -16.66272 15.69532 -37.97360 0.510 58.73995  ? 254 ARG A NE  1 
ATOM   1874 N  NE  B ARG A 1 256 ? -17.62535 12.76956 -38.47841 0.490 62.89976  ? 254 ARG A NE  1 
ATOM   1875 C  CZ  A ARG A 1 256 ? -16.21838 16.88422 -37.58319 0.510 58.08094  ? 254 ARG A CZ  1 
ATOM   1876 C  CZ  B ARG A 1 256 ? -16.58459 12.97657 -39.27397 0.490 61.70226  ? 254 ARG A CZ  1 
ATOM   1877 N  NH1 A ARG A 1 256 ? -16.61531 17.43326 -36.44513 0.510 54.79400  ? 254 ARG A NH1 1 
ATOM   1878 N  NH1 B ARG A 1 256 ? -15.82590 14.05457 -39.15084 0.490 60.50590  ? 254 ARG A NH1 1 
ATOM   1879 N  NH2 A ARG A 1 256 ? -15.34886 17.53669 -38.35059 0.510 53.59462  ? 254 ARG A NH2 1 
ATOM   1880 N  NH2 B ARG A 1 256 ? -16.30173 12.08407 -40.21939 0.490 60.60419  ? 254 ARG A NH2 1 
ATOM   1881 N  N   . ALA A 1 257 ? -22.98493 15.74694 -37.40451 1.000 53.92642  ? 255 ALA A N   1 
ATOM   1882 C  CA  . ALA A 1 257 ? -24.18434 15.45634 -36.62817 1.000 55.35952  ? 255 ALA A CA  1 
ATOM   1883 C  C   . ALA A 1 257 ? -25.31361 14.94857 -37.51378 1.000 59.23627  ? 255 ALA A C   1 
ATOM   1884 O  O   . ALA A 1 257 ? -26.09883 14.09595 -37.08822 1.000 65.26865  ? 255 ALA A O   1 
ATOM   1885 C  CB  . ALA A 1 257 ? -24.62222 16.70395 -35.86593 1.000 54.00382  ? 255 ALA A CB  1 
ATOM   1886 N  N   . ALA A 1 258 ? -25.41812 15.46486 -38.74195 1.000 54.15124  ? 256 ALA A N   1 
ATOM   1887 C  CA  . ALA A 1 258 ? -26.38963 14.92738 -39.68431 1.000 55.95925  ? 256 ALA A CA  1 
ATOM   1888 C  C   . ALA A 1 258 ? -26.05345 13.48988 -40.07339 1.000 58.40794  ? 256 ALA A C   1 
ATOM   1889 O  O   . ALA A 1 258 ? -26.96339 12.67588 -40.26033 1.000 57.34901  ? 256 ALA A O   1 
ATOM   1890 C  CB  . ALA A 1 258 ? -26.46091 15.81655 -40.92417 1.000 52.81773  ? 256 ALA A CB  1 
ATOM   1891 N  N   . GLU A 1 259 ? -24.76131 13.15580 -40.19155 1.000 59.47745  ? 257 GLU A N   1 
ATOM   1892 C  CA  . GLU A 1 259 ? -24.37781 11.77688 -40.50070 1.000 66.50459  ? 257 GLU A CA  1 
ATOM   1893 C  C   . GLU A 1 259 ? -24.67756 10.82163 -39.34330 1.000 67.06008  ? 257 GLU A C   1 
ATOM   1894 O  O   . GLU A 1 259 ? -25.17104 9.71046  -39.57155 1.000 64.04022  ? 257 GLU A O   1 
ATOM   1895 C  CB  . GLU A 1 259 ? -22.89800 11.69433 -40.86925 1.000 65.16158  ? 257 GLU A CB  1 
ATOM   1896 C  CG  . GLU A 1 259 ? -22.55525 10.38378 -41.57634 1.000 79.19847  ? 257 GLU A CG  1 
ATOM   1897 C  CD  . GLU A 1 259 ? -21.29164 10.47043 -42.41216 1.000 89.24851  ? 257 GLU A CD  1 
ATOM   1898 O  OE1 . GLU A 1 259 ? -20.51930 9.48283  -42.42517 1.000 99.28943  ? 257 GLU A OE1 1 
ATOM   1899 O  OE2 . GLU A 1 259 ? -21.06364 11.53038 -43.04116 1.000 90.36756  ? 257 GLU A OE2 1 
ATOM   1900 N  N   . ASP A 1 260 ? -24.36912 11.22154 -38.10014 1.000 57.13690  ? 258 ASP A N   1 
ATOM   1901 C  CA  . ASP A 1 260 ? -24.65515 10.36093 -36.95140 1.000 63.04986  ? 258 ASP A CA  1 
ATOM   1902 C  C   . ASP A 1 260 ? -26.13901 10.03819 -36.85042 1.000 70.42225  ? 258 ASP A C   1 
ATOM   1903 O  O   . ASP A 1 260 ? -26.51354 8.92655  -36.45690 1.000 70.59199  ? 258 ASP A O   1 
ATOM   1904 C  CB  . ASP A 1 260 ? -24.18052 11.01116 -35.64573 1.000 61.49610  ? 258 ASP A CB  1 
ATOM   1905 C  CG  . ASP A 1 260 ? -22.71046 11.41774 -35.68419 1.000 71.93870  ? 258 ASP A CG  1 
ATOM   1906 O  OD1 . ASP A 1 260 ? -21.92237 10.77534 -36.42036 1.000 71.81124  ? 258 ASP A OD1 1 
ATOM   1907 O  OD2 . ASP A 1 260 ? -22.34353 12.38974 -34.98055 1.000 72.33233  ? 258 ASP A OD2 1 
ATOM   1908 N  N   . ALA A 1 261 ? -26.99927 11.00603 -37.18325 1.000 69.67176  ? 259 ALA A N   1 
ATOM   1909 C  CA  . ALA A 1 261 ? -28.43338 10.79924 -37.04730 1.000 65.20531  ? 259 ALA A CA  1 
ATOM   1910 C  C   . ALA A 1 261 ? -28.94569 9.78598  -38.05959 1.000 64.12285  ? 259 ALA A C   1 
ATOM   1911 O  O   . ALA A 1 261 ? -29.91544 9.07025  -37.78228 1.000 68.60980  ? 259 ALA A O   1 
ATOM   1912 C  CB  . ALA A 1 261 ? -29.16464 12.13292 -37.19201 1.000 59.82287  ? 259 ALA A CB  1 
ATOM   1913 N  N   . TYR A 1 262 ? -28.30461 9.71048  -39.22808 1.000 64.57109  ? 260 TYR A N   1 
ATOM   1914 C  CA  . TYR A 1 262 ? -28.66778 8.71067  -40.22955 1.000 73.71466  ? 260 TYR A CA  1 
ATOM   1915 C  C   . TYR A 1 262 ? -28.34049 7.29173  -39.75675 1.000 74.86098  ? 260 TYR A C   1 
ATOM   1916 O  O   . TYR A 1 262 ? -29.17747 6.38593  -39.86271 1.000 72.82065  ? 260 TYR A O   1 
ATOM   1917 C  CB  . TYR A 1 262 ? -27.96229 9.01369  -41.55474 1.000 62.74474  ? 260 TYR A CB  1 
ATOM   1918 C  CG  . TYR A 1 262 ? -28.09418 7.88808  -42.55101 1.000 66.99511  ? 260 TYR A CG  1 
ATOM   1919 C  CD1 . TYR A 1 262 ? -29.30628 7.63291  -43.18118 1.000 71.47999  ? 260 TYR A CD1 1 
ATOM   1920 C  CD2 . TYR A 1 262 ? -27.01323 7.06200  -42.84075 1.000 75.32853  ? 260 TYR A CD2 1 
ATOM   1921 C  CE1 . TYR A 1 262 ? -29.43958 6.59686  -44.08503 1.000 79.51241  ? 260 TYR A CE1 1 
ATOM   1922 C  CE2 . TYR A 1 262 ? -27.13451 6.01694  -43.74256 1.000 83.16597  ? 260 TYR A CE2 1 
ATOM   1923 C  CZ  . TYR A 1 262 ? -28.35370 5.78968  -44.36745 1.000 84.78172  ? 260 TYR A CZ  1 
ATOM   1924 O  OH  . TYR A 1 262 ? -28.50160 4.75507  -45.27100 1.000 83.43045  ? 260 TYR A OH  1 
ATOM   1925 N  N   . TRP A 1 263 ? -27.12138 7.07447  -39.24652 1.000 69.40364  ? 261 TRP A N   1 
ATOM   1926 C  CA  . TRP A 1 263 ? -26.76062 5.75693  -38.72434 1.000 78.33060  ? 261 TRP A CA  1 
ATOM   1927 C  C   . TRP A 1 263 ? -27.62344 5.38729  -37.52310 1.000 72.99029  ? 261 TRP A C   1 
ATOM   1928 O  O   . TRP A 1 263 ? -28.04140 4.23258  -37.37629 1.000 79.41567  ? 261 TRP A O   1 
ATOM   1929 C  CB  . TRP A 1 263 ? -25.27084 5.72894  -38.37052 1.000 72.72489  ? 261 TRP A CB  1 
ATOM   1930 C  CG  . TRP A 1 263 ? -24.40273 5.79669  -39.60835 1.000 85.14171  ? 261 TRP A CG  1 
ATOM   1931 C  CD1 . TRP A 1 263 ? -23.53294 6.80232  -39.96147 1.000 85.99561  ? 261 TRP A CD1 1 
ATOM   1932 C  CD2 . TRP A 1 263 ? -24.34897 4.83196  -40.67181 1.000 87.03700  ? 261 TRP A CD2 1 
ATOM   1933 N  NE1 . TRP A 1 263 ? -22.94171 6.51394  -41.17378 1.000 84.18213  ? 261 TRP A NE1 1 
ATOM   1934 C  CE2 . TRP A 1 263 ? -23.42198 5.31032  -41.62726 1.000 92.92944  ? 261 TRP A CE2 1 
ATOM   1935 C  CE3 . TRP A 1 263 ? -24.98426 3.60501  -40.90259 1.000 84.75615  ? 261 TRP A CE3 1 
ATOM   1936 C  CZ2 . TRP A 1 263 ? -23.12048 4.60121  -42.79630 1.000 97.62139  ? 261 TRP A CZ2 1 
ATOM   1937 C  CZ3 . TRP A 1 263 ? -24.68433 2.90599  -42.06358 1.000 89.25075  ? 261 TRP A CZ3 1 
ATOM   1938 C  CH2 . TRP A 1 263 ? -23.76236 3.40605  -42.99490 1.000 95.19040  ? 261 TRP A CH2 1 
ATOM   1939 N  N   . LEU A 1 264 ? -27.94699 6.37220  -36.68786 1.000 67.80517  ? 262 LEU A N   1 
ATOM   1940 C  CA  . LEU A 1 264 ? -28.74550 6.12924  -35.49515 1.000 73.17178  ? 262 LEU A CA  1 
ATOM   1941 C  C   . LEU A 1 264 ? -30.20262 5.80826  -35.81284 1.000 77.17920  ? 262 LEU A C   1 
ATOM   1942 O  O   . LEU A 1 264 ? -30.85654 5.11762  -35.02387 1.000 78.34662  ? 262 LEU A O   1 
ATOM   1943 C  CB  . LEU A 1 264 ? -28.67522 7.34741  -34.57401 1.000 74.13134  ? 262 LEU A CB  1 
ATOM   1944 C  CG  . LEU A 1 264 ? -27.85734 7.19962  -33.29491 1.000 76.20542  ? 262 LEU A CG  1 
ATOM   1945 C  CD1 . LEU A 1 264 ? -27.06377 8.46516  -33.00835 1.000 68.68423  ? 262 LEU A CD1 1 
ATOM   1946 C  CD2 . LEU A 1 264 ? -28.79172 6.84862  -32.14172 1.000 83.40794  ? 262 LEU A CD2 1 
ATOM   1947 N  N   . LEU A 1 265 ? -30.74319 6.30312  -36.93652 1.000 74.16249  ? 263 LEU A N   1 
ATOM   1948 C  CA  . LEU A 1 265 ? -32.18861 6.24481  -37.16584 1.000 75.09062  ? 263 LEU A CA  1 
ATOM   1949 C  C   . LEU A 1 265 ? -32.61317 5.80145  -38.56674 1.000 76.59267  ? 263 LEU A C   1 
ATOM   1950 O  O   . LEU A 1 265 ? -33.81417 5.59551  -38.78292 1.000 72.91329  ? 263 LEU A O   1 
ATOM   1951 C  CB  . LEU A 1 265 ? -32.82834 7.61818  -36.88034 1.000 70.26986  ? 263 LEU A CB  1 
ATOM   1952 C  CG  . LEU A 1 265 ? -32.46323 8.41073  -35.60991 1.000 82.23341  ? 263 LEU A CG  1 
ATOM   1953 C  CD1 . LEU A 1 265 ? -33.24125 9.73188  -35.53428 1.000 74.90164  ? 263 LEU A CD1 1 
ATOM   1954 C  CD2 . LEU A 1 265 ? -32.67571 7.60126  -34.31914 1.000 76.58507  ? 263 LEU A CD2 1 
ATOM   1955 N  N   . GLY A 1 266 ? -31.69138 5.65194  -39.51842 1.000 79.34733  ? 264 GLY A N   1 
ATOM   1956 C  CA  . GLY A 1 266 ? -32.07959 5.30083  -40.87409 1.000 81.66211  ? 264 GLY A CA  1 
ATOM   1957 C  C   . GLY A 1 266 ? -31.48211 4.01928  -41.42929 1.000 90.09398  ? 264 GLY A C   1 
ATOM   1958 O  O   . GLY A 1 266 ? -31.26648 3.91032  -42.64148 1.000 88.56841  ? 264 GLY A O   1 
ATOM   1959 N  N   . THR A 1 267 ? -31.22151 3.03678  -40.56643 1.000 101.55046 ? 265 THR A N   1 
ATOM   1960 C  CA  . THR A 1 267 ? -30.63109 1.76772  -41.00697 1.000 109.35105 ? 265 THR A CA  1 
ATOM   1961 C  C   . THR A 1 267 ? -31.42683 0.55727  -40.50550 1.000 103.94716 ? 265 THR A C   1 
ATOM   1962 O  O   . THR A 1 267 ? -32.47547 0.21830  -41.06344 1.000 103.01188 ? 265 THR A O   1 
ATOM   1963 C  CB  . THR A 1 267 ? -29.14688 1.64175  -40.55222 1.000 99.25445  ? 265 THR A CB  1 
ATOM   1964 O  OG1 . THR A 1 267 ? -29.02989 1.96231  -39.15799 1.000 93.45580  ? 265 THR A OG1 1 
ATOM   1965 C  CG2 . THR A 1 267 ? -28.25543 2.57403  -41.37243 1.000 85.67532  ? 265 THR A CG2 1 
ATOM   1966 N  N   . SER B 1 6   ? -5.60191  52.26665 -41.77504 1.000 106.98209 ? 4   SER B N   1 
ATOM   1967 C  CA  . SER B 1 6   ? -6.59314  51.19453 -41.70008 1.000 103.53739 ? 4   SER B CA  1 
ATOM   1968 C  C   . SER B 1 6   ? -6.02559  49.85683 -42.21401 1.000 98.72493  ? 4   SER B C   1 
ATOM   1969 O  O   . SER B 1 6   ? -5.81219  49.68400 -43.41790 1.000 94.13511  ? 4   SER B O   1 
ATOM   1970 C  CB  . SER B 1 6   ? -7.86628  51.57855 -42.48184 1.000 95.20399  ? 4   SER B CB  1 
ATOM   1971 O  OG  . SER B 1 6   ? -7.60624  51.82341 -43.86224 1.000 84.08233  ? 4   SER B OG  1 
ATOM   1972 N  N   . LEU B 1 7   ? -5.75254  48.93784 -41.27799 1.000 103.88919 ? 5   LEU B N   1 
ATOM   1973 C  CA  . LEU B 1 7   ? -5.46213  47.53098 -41.55714 1.000 92.00198  ? 5   LEU B CA  1 
ATOM   1974 C  C   . LEU B 1 7   ? -6.58793  46.62225 -41.06098 1.000 87.15322  ? 5   LEU B C   1 
ATOM   1975 O  O   . LEU B 1 7   ? -6.44677  45.39263 -41.08959 1.000 79.76972  ? 5   LEU B O   1 
ATOM   1976 C  CB  . LEU B 1 7   ? -4.12730  47.12020 -40.91375 1.000 87.91253  ? 5   LEU B CB  1 
ATOM   1977 C  CG  . LEU B 1 7   ? -2.90167  46.66439 -41.73034 1.000 87.00139  ? 5   LEU B CG  1 
ATOM   1978 C  CD1 . LEU B 1 7   ? -2.95977  45.18150 -42.07609 1.000 80.28441  ? 5   LEU B CD1 1 
ATOM   1979 C  CD2 . LEU B 1 7   ? -2.68510  47.51661 -42.98543 1.000 82.44350  ? 5   LEU B CD2 1 
ATOM   1980 N  N   . ASN B 1 8   ? -7.72185  47.21256 -40.63141 1.000 93.63743  ? 6   ASN B N   1 
ATOM   1981 C  CA  . ASN B 1 8   ? -8.77888  46.55211 -39.86827 1.000 86.68527  ? 6   ASN B CA  1 
ATOM   1982 C  C   . ASN B 1 8   ? -9.89810  47.52967 -39.50261 1.000 86.29902  ? 6   ASN B C   1 
ATOM   1983 O  O   . ASN B 1 8   ? -9.61157  48.70298 -39.22676 1.000 90.41157  ? 6   ASN B O   1 
ATOM   1984 C  CB  . ASN B 1 8   ? -8.18220  45.95628 -38.59762 1.000 78.68659  ? 6   ASN B CB  1 
ATOM   1985 C  CG  . ASN B 1 8   ? -8.88223  44.71098 -38.16295 1.000 83.41785  ? 6   ASN B CG  1 
ATOM   1986 O  OD1 . ASN B 1 8   ? -9.87308  44.77220 -37.43658 1.000 86.04511  ? 6   ASN B OD1 1 
ATOM   1987 N  ND2 . ASN B 1 8   ? -8.36907  43.55425 -38.59543 1.000 87.06276  ? 6   ASN B ND2 1 
ATOM   1988 N  N   . PRO B 1 9   ? -11.19539 47.11314 -39.51728 1.000 81.51840  ? 7   PRO B N   1 
ATOM   1989 C  CA  . PRO B 1 9   ? -12.21958 47.93559 -38.85535 1.000 88.47817  ? 7   PRO B CA  1 
ATOM   1990 C  C   . PRO B 1 9   ? -12.51490 47.52820 -37.41280 1.000 90.72439  ? 7   PRO B C   1 
ATOM   1991 O  O   . PRO B 1 9   ? -13.62873 47.75961 -36.94203 1.000 94.14723  ? 7   PRO B O   1 
ATOM   1992 C  CB  . PRO B 1 9   ? -13.46319 47.74836 -39.74973 1.000 89.86450  ? 7   PRO B CB  1 
ATOM   1993 C  CG  . PRO B 1 9   ? -12.97048 47.13486 -41.03325 1.000 79.10940  ? 7   PRO B CG  1 
ATOM   1994 C  CD  . PRO B 1 9   ? -11.80701 46.28373 -40.56894 1.000 84.47231  ? 7   PRO B CD  1 
ATOM   1995 N  N   . ASP B 1 10  ? -11.56037 46.93644 -36.68893 1.000 95.32410  ? 8   ASP B N   1 
ATOM   1996 C  CA  . ASP B 1 10  ? -11.77328 46.67314 -35.26541 1.000 92.18325  ? 8   ASP B CA  1 
ATOM   1997 C  C   . ASP B 1 10  ? -10.64626 47.26138 -34.42141 1.000 99.97360  ? 8   ASP B C   1 
ATOM   1998 O  O   . ASP B 1 10  ? -9.86182  48.08882 -34.90392 1.000 88.46659  ? 8   ASP B O   1 
ATOM   1999 C  CB  . ASP B 1 10  ? -11.88482 45.16779 -34.97323 1.000 92.98157  ? 8   ASP B CB  1 
ATOM   2000 C  CG  . ASP B 1 10  ? -12.82661 44.43328 -35.93112 1.000 85.93594  ? 8   ASP B CG  1 
ATOM   2001 O  OD1 . ASP B 1 10  ? -12.62689 44.53731 -37.15651 1.000 80.04496  ? 8   ASP B OD1 1 
ATOM   2002 O  OD2 . ASP B 1 10  ? -13.74047 43.71879 -35.45753 1.000 71.51151  ? 8   ASP B OD2 1 
ATOM   2003 N  N   . GLU B 1 11  ? -10.58606 46.84815 -33.13943 1.000 113.89717 ? 9   GLU B N   1 
ATOM   2004 C  CA  . GLU B 1 11  ? -9.46599  47.07384 -32.23137 1.000 104.22688 ? 9   GLU B CA  1 
ATOM   2005 C  C   . GLU B 1 11  ? -9.41024  45.95053 -31.18459 1.000 111.59197 ? 9   GLU B C   1 
ATOM   2006 O  O   . GLU B 1 11  ? -8.33225  45.36462 -31.00800 1.000 115.92717 ? 9   GLU B O   1 
ATOM   2007 C  CB  . GLU B 1 11  ? -9.54099  48.45997 -31.57920 1.000 109.54047 ? 9   GLU B CB  1 
ATOM   2008 C  CG  . GLU B 1 11  ? -8.95780  49.58910 -32.41679 1.000 119.98491 ? 9   GLU B CG  1 
ATOM   2009 C  CD  . GLU B 1 11  ? -9.49064  50.94595 -31.99205 1.000 125.74445 ? 9   GLU B CD  1 
ATOM   2010 O  OE1 . GLU B 1 11  ? -10.26592 50.98588 -31.01013 1.000 113.51172 ? 9   GLU B OE1 1 
ATOM   2011 O  OE2 . GLU B 1 11  ? -9.14823  51.96342 -32.64043 1.000 125.25484 ? 9   GLU B OE2 1 
ATOM   2012 N  N   . PRO B 1 12  ? -10.49455 45.59945 -30.47157 1.000 117.04602 ? 10  PRO B N   1 
ATOM   2013 C  CA  . PRO B 1 12  ? -10.44117 44.38201 -29.64726 1.000 117.73978 ? 10  PRO B CA  1 
ATOM   2014 C  C   . PRO B 1 12  ? -10.92896 43.16661 -30.41744 1.000 115.93812 ? 10  PRO B C   1 
ATOM   2015 O  O   . PRO B 1 12  ? -11.80319 43.26453 -31.28420 1.000 107.89464 ? 10  PRO B O   1 
ATOM   2016 C  CB  . PRO B 1 12  ? -11.40800 44.66720 -28.48920 1.000 116.35251 ? 10  PRO B CB  1 
ATOM   2017 C  CG  . PRO B 1 12  ? -12.20164 45.83912 -28.87675 1.000 114.19211 ? 10  PRO B CG  1 
ATOM   2018 C  CD  . PRO B 1 12  ? -11.60687 46.48750 -30.07783 1.000 115.49732 ? 10  PRO B CD  1 
ATOM   2019 N  N   . ASN B 1 13  ? -10.37978 41.99425 -30.05155 1.000 112.03038 ? 11  ASN B N   1 
ATOM   2020 C  CA  . ASN B 1 13  ? -10.75927 40.75158 -30.73048 1.000 119.88811 ? 11  ASN B CA  1 
ATOM   2021 C  C   . ASN B 1 13  ? -10.13197 39.46231 -30.19174 1.000 110.16851 ? 11  ASN B C   1 
ATOM   2022 O  O   . ASN B 1 13  ? -9.38722  39.46496 -29.20273 1.000 99.49532  ? 11  ASN B O   1 
ATOM   2023 C  CB  . ASN B 1 13  ? -10.41783 40.84771 -32.23006 1.000 108.86674 ? 11  ASN B CB  1 
ATOM   2024 C  CG  . ASN B 1 13  ? -8.99245  40.36644 -32.55017 1.000 112.39641 ? 11  ASN B CG  1 
ATOM   2025 O  OD1 . ASN B 1 13  ? -8.02660  40.77282 -31.89291 1.000 120.45769 ? 11  ASN B OD1 1 
ATOM   2026 N  ND2 . ASN B 1 13  ? -8.86217  39.49625 -33.56039 1.000 99.95900  ? 11  ASN B ND2 1 
ATOM   2027 N  N   . ALA B 1 14  ? -10.48868 38.35044 -30.85560 1.000 95.44037  ? 12  ALA B N   1 
ATOM   2028 C  CA  . ALA B 1 14  ? -9.73008  37.11055 -30.85102 1.000 91.46979  ? 12  ALA B CA  1 
ATOM   2029 C  C   . ALA B 1 14  ? -9.35115  36.83510 -32.29948 1.000 96.61275  ? 12  ALA B C   1 
ATOM   2030 O  O   . ALA B 1 14  ? -8.42387  37.46565 -32.82984 1.000 92.03251  ? 12  ALA B O   1 
ATOM   2031 C  CB  . ALA B 1 14  ? -10.55039 35.98555 -30.20708 1.000 82.44436  ? 12  ALA B CB  1 
ATOM   2032 N  N   . LEU B 1 15  ? -10.03835 35.91392 -32.97744 1.000 97.09483  ? 13  LEU B N   1 
ATOM   2033 C  CA  . LEU B 1 15  ? -10.04305 35.81387 -34.43302 1.000 85.58189  ? 13  LEU B CA  1 
ATOM   2034 C  C   . LEU B 1 15  ? -11.20861 36.58589 -35.05468 1.000 83.12479  ? 13  LEU B C   1 
ATOM   2035 O  O   . LEU B 1 15  ? -11.61687 36.28311 -36.18620 1.000 73.35309  ? 13  LEU B O   1 
ATOM   2036 C  CB  . LEU B 1 15  ? -10.13121 34.34827 -34.87259 1.000 84.86278  ? 13  LEU B CB  1 
ATOM   2037 C  CG  . LEU B 1 15  ? -9.03467  33.30098 -34.67647 1.000 84.59658  ? 13  LEU B CG  1 
ATOM   2038 C  CD1 . LEU B 1 15  ? -8.55814  33.19313 -33.22316 1.000 77.56984  ? 13  LEU B CD1 1 
ATOM   2039 C  CD2 . LEU B 1 15  ? -9.57583  31.96145 -35.15740 1.000 79.13522  ? 13  LEU B CD2 1 
ATOM   2040 N  N   . LEU B 1 16  ? -11.78075 37.53444 -34.31446 1.000 78.78389  ? 14  LEU B N   1 
ATOM   2041 C  CA  . LEU B 1 16  ? -12.94704 38.30097 -34.72593 1.000 69.11268  ? 14  LEU B CA  1 
ATOM   2042 C  C   . LEU B 1 16  ? -12.57326 39.55958 -35.49101 1.000 64.34324  ? 14  LEU B C   1 
ATOM   2043 O  O   . LEU B 1 16  ? -13.43247 40.41293 -35.72428 1.000 66.56411  ? 14  LEU B O   1 
ATOM   2044 C  CB  . LEU B 1 16  ? -13.78712 38.66542 -33.49720 1.000 65.17526  ? 14  LEU B CB  1 
ATOM   2045 C  CG  . LEU B 1 16  ? -14.17009 37.48546 -32.59868 1.000 65.18124  ? 14  LEU B CG  1 
ATOM   2046 C  CD1 . LEU B 1 16  ? -15.18007 37.88785 -31.52701 1.000 59.22981  ? 14  LEU B CD1 1 
ATOM   2047 C  CD2 . LEU B 1 16  ? -14.73880 36.36786 -33.44894 1.000 60.22517  ? 14  LEU B CD2 1 
ATOM   2048 N  N   . SER B 1 17  ? -11.31653 39.69698 -35.87773 1.000 59.64073  ? 15  SER B N   1 
ATOM   2049 C  CA  . SER B 1 17  ? -10.84460 40.90130 -36.53120 1.000 68.86122  ? 15  SER B CA  1 
ATOM   2050 C  C   . SER B 1 17  ? -11.11137 40.82210 -38.02625 1.000 68.36847  ? 15  SER B C   1 
ATOM   2051 O  O   . SER B 1 17  ? -10.89512 39.78138 -38.65458 1.000 63.05383  ? 15  SER B O   1 
ATOM   2052 C  CB  . SER B 1 17  ? -9.35103  41.08403 -36.27951 1.000 78.19510  ? 15  SER B CB  1 
ATOM   2053 O  OG  . SER B 1 17  ? -9.03938  42.45418 -36.16756 1.000 84.16371  ? 15  SER B OG  1 
ATOM   2054 N  N   . TYR B 1 18  ? -11.59096 41.92143 -38.59734 1.000 60.45598  ? 16  TYR B N   1 
ATOM   2055 C  CA  . TYR B 1 18  ? -11.78761 41.95474 -40.04050 1.000 62.79515  ? 16  TYR B CA  1 
ATOM   2056 C  C   . TYR B 1 18  ? -10.51449 42.51406 -40.65583 1.000 62.29085  ? 16  TYR B C   1 
ATOM   2057 O  O   . TYR B 1 18  ? -10.33668 43.72215 -40.77457 1.000 56.47829  ? 16  TYR B O   1 
ATOM   2058 C  CB  . TYR B 1 18  ? -13.02039 42.76088 -40.43557 1.000 56.81804  ? 16  TYR B CB  1 
ATOM   2059 C  CG  . TYR B 1 18  ? -13.41174 42.44459 -41.85753 1.000 50.40126  ? 16  TYR B CG  1 
ATOM   2060 C  CD1 . TYR B 1 18  ? -14.20909 41.33762 -42.14519 1.000 49.82941  ? 16  TYR B CD1 1 
ATOM   2061 C  CD2 . TYR B 1 18  ? -12.92428 43.20561 -42.92221 1.000 49.15270  ? 16  TYR B CD2 1 
ATOM   2062 C  CE1 . TYR B 1 18  ? -14.54580 41.01286 -43.46486 1.000 48.55601  ? 16  TYR B CE1 1 
ATOM   2063 C  CE2 . TYR B 1 18  ? -13.25809 42.89861 -44.23660 1.000 47.86297  ? 16  TYR B CE2 1 
ATOM   2064 C  CZ  . TYR B 1 18  ? -14.06613 41.79502 -44.49973 1.000 46.30247  ? 16  TYR B CZ  1 
ATOM   2065 O  OH  . TYR B 1 18  ? -14.39941 41.47146 -45.79649 1.000 56.59809  ? 16  TYR B OH  1 
ATOM   2066 N  N   . ASP B 1 19  ? -9.61827  41.61317 -41.05383 1.000 61.63817  ? 17  ASP B N   1 
ATOM   2067 C  CA  . ASP B 1 19  ? -8.34587  42.00270 -41.64758 1.000 67.86752  ? 17  ASP B CA  1 
ATOM   2068 C  C   . ASP B 1 19  ? -8.53955  42.39491 -43.10506 1.000 59.09746  ? 17  ASP B C   1 
ATOM   2069 O  O   . ASP B 1 19  ? -9.10789  41.62723 -43.88769 1.000 60.69311  ? 17  ASP B O   1 
ATOM   2070 C  CB  . ASP B 1 19  ? -7.33316  40.85599 -41.54320 1.000 76.45529  ? 17  ASP B CB  1 
ATOM   2071 C  CG  . ASP B 1 19  ? -6.85545  40.61174 -40.10373 1.000 91.16495  ? 17  ASP B CG  1 
ATOM   2072 O  OD1 . ASP B 1 19  ? -6.66162  39.43068 -39.72643 1.000 94.27459  ? 17  ASP B OD1 1 
ATOM   2073 O  OD2 . ASP B 1 19  ? -6.67169  41.59973 -39.35116 1.000 90.07267  ? 17  ASP B OD2 1 
ATOM   2074 N  N   . PHE B 1 20  ? -8.07458  43.58745 -43.47098 1.000 61.97683  ? 18  PHE B N   1 
ATOM   2075 C  CA  . PHE B 1 20  ? -8.10398  44.01305 -44.87155 1.000 61.19443  ? 18  PHE B CA  1 
ATOM   2076 C  C   . PHE B 1 20  ? -6.92217  44.94622 -45.12482 1.000 61.71317  ? 18  PHE B C   1 
ATOM   2077 O  O   . PHE B 1 20  ? -6.04340  45.10811 -44.27290 1.000 68.28863  ? 18  PHE B O   1 
ATOM   2078 C  CB  . PHE B 1 20  ? -9.46452  44.63727 -45.22643 1.000 59.59769  ? 18  PHE B CB  1 
ATOM   2079 C  CG  . PHE B 1 20  ? -9.63734  46.06844 -44.77278 1.000 57.83578  ? 18  PHE B CG  1 
ATOM   2080 C  CD1 . PHE B 1 20  ? -9.71937  46.38846 -43.42748 1.000 66.37984  ? 18  PHE B CD1 1 
ATOM   2081 C  CD2 . PHE B 1 20  ? -9.75073  47.08925 -45.70057 1.000 54.95958  ? 18  PHE B CD2 1 
ATOM   2082 C  CE1 . PHE B 1 20  ? -9.88908  47.70834 -43.02247 1.000 72.36829  ? 18  PHE B CE1 1 
ATOM   2083 C  CE2 . PHE B 1 20  ? -9.92575  48.40767 -45.29795 1.000 62.78570  ? 18  PHE B CE2 1 
ATOM   2084 C  CZ  . PHE B 1 20  ? -9.99126  48.71339 -43.95900 1.000 67.62975  ? 18  PHE B CZ  1 
ATOM   2085 N  N   . ASP B 1 21  ? -6.89133  45.53883 -46.32016 1.000 60.99806  ? 19  ASP B N   1 
ATOM   2086 C  CA  . ASP B 1 21  ? -5.78165  46.38363 -46.77431 1.000 64.73767  ? 19  ASP B CA  1 
ATOM   2087 C  C   . ASP B 1 21  ? -4.43738  45.64198 -46.70423 1.000 65.39345  ? 19  ASP B C   1 
ATOM   2088 O  O   . ASP B 1 21  ? -3.45043  46.13597 -46.16081 1.000 61.60043  ? 19  ASP B O   1 
ATOM   2089 C  CB  . ASP B 1 21  ? -5.73387  47.69263 -45.98687 1.000 65.83013  ? 19  ASP B CB  1 
ATOM   2090 C  CG  . ASP B 1 21  ? -4.88304  48.74090 -46.66939 1.000 73.74174  ? 19  ASP B CG  1 
ATOM   2091 O  OD1 . ASP B 1 21  ? -4.69423  48.62661 -47.90014 1.000 66.89636  ? 19  ASP B OD1 1 
ATOM   2092 O  OD2 . ASP B 1 21  ? -4.39041  49.66004 -45.97870 1.000 82.50710  ? 19  ASP B OD2 1 
ATOM   2093 N  N   . ARG B 1 22  ? -4.40656  44.43886 -47.27609 1.000 66.54925  ? 20  ARG B N   1 
ATOM   2094 C  CA  . ARG B 1 22  ? -3.25821  43.55025 -47.19164 1.000 55.43461  ? 20  ARG B CA  1 
ATOM   2095 C  C   . ARG B 1 22  ? -2.36417  43.63971 -48.42680 1.000 55.96075  ? 20  ARG B C   1 
ATOM   2096 O  O   . ARG B 1 22  ? -1.41457  42.86192 -48.55019 1.000 63.05417  ? 20  ARG B O   1 
ATOM   2097 C  CB  . ARG B 1 22  ? -3.73141  42.10614 -46.96650 1.000 60.12162  ? 20  ARG B CB  1 
ATOM   2098 C  CG  . ARG B 1 22  ? -4.30342  41.81079 -45.56961 1.000 61.49714  ? 20  ARG B CG  1 
ATOM   2099 C  CD  . ARG B 1 22  ? -3.60311  42.64641 -44.50351 1.000 74.12556  ? 20  ARG B CD  1 
ATOM   2100 N  NE  . ARG B 1 22  ? -3.73708  42.13786 -43.13731 1.000 96.79528  ? 20  ARG B NE  1 
ATOM   2101 C  CZ  . ARG B 1 22  ? -3.29150  40.96302 -42.69873 1.000 102.02709 ? 20  ARG B CZ  1 
ATOM   2102 N  NH1 . ARG B 1 22  ? -2.72208  40.08433 -43.51410 1.000 91.57430  ? 20  ARG B NH1 1 
ATOM   2103 N  NH2 . ARG B 1 22  ? -3.41182  40.66546 -41.40346 1.000 94.38542  ? 20  ARG B NH2 1 
ATOM   2104 N  N   . GLY B 1 23  ? -2.64694  44.56513 -49.34584 1.000 54.32756  ? 21  GLY B N   1 
ATOM   2105 C  CA  . GLY B 1 23  ? -1.78419  44.81403 -50.48443 1.000 44.78575  ? 21  GLY B CA  1 
ATOM   2106 C  C   . GLY B 1 23  ? -1.84986  43.80803 -51.61425 1.000 52.14911  ? 21  GLY B C   1 
ATOM   2107 O  O   . GLY B 1 23  ? -1.15737  44.00199 -52.62461 1.000 51.77249  ? 21  GLY B O   1 
ATOM   2108 N  N   . SER B 1 24  ? -2.65035  42.74512 -51.48809 1.000 51.58333  ? 22  SER B N   1 
ATOM   2109 C  CA  . SER B 1 24  ? -2.76716  41.74407 -52.54458 1.000 46.49029  ? 22  SER B CA  1 
ATOM   2110 C  C   . SER B 1 24  ? -3.22656  42.38566 -53.85047 1.000 46.15335  ? 22  SER B C   1 
ATOM   2111 O  O   . SER B 1 24  ? -3.82516  43.46252 -53.87056 1.000 49.65695  ? 22  SER B O   1 
ATOM   2112 C  CB  . SER B 1 24  ? -3.74888  40.64378 -52.13373 1.000 59.92901  ? 22  SER B CB  1 
ATOM   2113 O  OG  . SER B 1 24  ? -5.09676  41.10181 -52.15726 1.000 53.72009  ? 22  SER B OG  1 
ATOM   2114 N  N   . ASN B 1 25  ? -2.93502  41.71669 -54.96101 1.000 45.88839  ? 23  ASN B N   1 
ATOM   2115 C  CA  . ASN B 1 25  ? -3.34943  42.28526 -56.23463 1.000 50.95965  ? 23  ASN B CA  1 
ATOM   2116 C  C   . ASN B 1 25  ? -4.83792  42.08270 -56.51174 1.000 53.90493  ? 23  ASN B C   1 
ATOM   2117 O  O   . ASN B 1 25  ? -5.40804  42.83395 -57.31903 1.000 50.04149  ? 23  ASN B O   1 
ATOM   2118 C  CB  . ASN B 1 25  ? -2.49461  41.72017 -57.36407 1.000 54.08604  ? 23  ASN B CB  1 
ATOM   2119 C  CG  . ASN B 1 25  ? -1.45162  42.71730 -57.83451 1.000 55.26530  ? 23  ASN B CG  1 
ATOM   2120 O  OD1 . ASN B 1 25  ? -1.51578  43.90224 -57.49089 1.000 46.00470  ? 23  ASN B OD1 1 
ATOM   2121 N  ND2 . ASN B 1 25  ? -0.46809  42.23911 -58.58523 1.000 51.80823  ? 23  ASN B ND2 1 
ATOM   2122 N  N   . TYR B 1 26  ? -5.47030  41.10639 -55.84378 1.000 47.99986  ? 24  TYR B N   1 
ATOM   2123 C  CA  . TYR B 1 26  ? -6.92722  41.05434 -55.76224 1.000 47.75045  ? 24  TYR B CA  1 
ATOM   2124 C  C   . TYR B 1 26  ? -7.49444  42.38049 -55.25437 1.000 47.44497  ? 24  TYR B C   1 
ATOM   2125 O  O   . TYR B 1 26  ? -8.31834  43.01197 -55.92251 1.000 45.50932  ? 24  TYR B O   1 
ATOM   2126 C  CB  . TYR B 1 26  ? -7.34707  39.89808 -54.84972 1.000 52.37853  ? 24  TYR B CB  1 
ATOM   2127 C  CG  . TYR B 1 26  ? -8.84040  39.69973 -54.74085 1.000 46.93138  ? 24  TYR B CG  1 
ATOM   2128 C  CD1 . TYR B 1 26  ? -9.53679  38.95892 -55.69641 1.000 48.76299  ? 24  TYR B CD1 1 
ATOM   2129 C  CD2 . TYR B 1 26  ? -9.55920  40.27036 -53.69870 1.000 52.26072  ? 24  TYR B CD2 1 
ATOM   2130 C  CE1 . TYR B 1 26  ? -10.90394 38.78378 -55.60921 1.000 49.01093  ? 24  TYR B CE1 1 
ATOM   2131 C  CE2 . TYR B 1 26  ? -10.93974 40.10908 -53.59844 1.000 52.36698  ? 24  TYR B CE2 1 
ATOM   2132 C  CZ  . TYR B 1 26  ? -11.60514 39.36154 -54.55701 1.000 53.20621  ? 24  TYR B CZ  1 
ATOM   2133 O  OH  . TYR B 1 26  ? -12.96357 39.18647 -54.46165 1.000 44.00581  ? 24  TYR B OH  1 
ATOM   2134 N  N   . GLU B 1 27  ? -7.01872  42.84717 -54.09500 1.000 47.02406  ? 25  GLU B N   1 
ATOM   2135 C  CA  . GLU B 1 27  ? -7.48448  44.12905 -53.55829 1.000 50.01153  ? 25  GLU B CA  1 
ATOM   2136 C  C   . GLU B 1 27  ? -7.09953  45.31224 -54.45663 1.000 48.08970  ? 25  GLU B C   1 
ATOM   2137 O  O   . GLU B 1 27  ? -7.88176  46.25320 -54.61109 1.000 52.95972  ? 25  GLU B O   1 
ATOM   2138 C  CB  . GLU B 1 27  ? -6.94399  44.32997 -52.13999 1.000 45.81512  ? 25  GLU B CB  1 
ATOM   2139 C  CG  . GLU B 1 27  ? -7.31178  43.20602 -51.19301 1.000 54.22819  ? 25  GLU B CG  1 
ATOM   2140 C  CD  . GLU B 1 27  ? -6.46109  43.16714 -49.91862 1.000 62.16363  ? 25  GLU B CD  1 
ATOM   2141 O  OE1 . GLU B 1 27  ? -6.73435  43.97563 -49.00475 1.000 59.69173  ? 25  GLU B OE1 1 
ATOM   2142 O  OE2 . GLU B 1 27  ? -5.53090  42.31878 -49.83231 1.000 59.09976  ? 25  GLU B OE2 1 
ATOM   2143 N  N   . ASN B 1 28  ? -5.90325  45.29222 -55.05805 1.000 50.82893  ? 26  ASN B N   1 
ATOM   2144 C  CA  . ASN B 1 28  ? -5.46396  46.43325 -55.86621 1.000 46.15069  ? 26  ASN B CA  1 
ATOM   2145 C  C   . ASN B 1 28  ? -6.31932  46.58097 -57.11968 1.000 49.94348  ? 26  ASN B C   1 
ATOM   2146 O  O   . ASN B 1 28  ? -6.76983  47.68237 -57.45183 1.000 48.14038  ? 26  ASN B O   1 
ATOM   2147 C  CB  . ASN B 1 28  ? -3.98663  46.28739 -56.27390 1.000 54.55835  ? 26  ASN B CB  1 
ATOM   2148 C  CG  . ASN B 1 28  ? -3.02176  46.27588 -55.08407 1.000 59.33980  ? 26  ASN B CG  1 
ATOM   2149 O  OD1 . ASN B 1 28  ? -3.25220  46.93761 -54.06760 1.000 55.58857  ? 26  ASN B OD1 1 
ATOM   2150 N  ND2 . ASN B 1 28  ? -1.92682  45.51176 -55.21863 1.000 50.09890  ? 26  ASN B ND2 1 
ATOM   2151 N  N   . VAL B 1 29  ? -6.52337  45.48039 -57.84617 1.000 47.97539  ? 27  VAL B N   1 
ATOM   2152 C  CA  . VAL B 1 29  ? -7.29241  45.52607 -59.08602 1.000 49.84215  ? 27  VAL B CA  1 
ATOM   2153 C  C   . VAL B 1 29  ? -8.70827  46.04476 -58.82808 1.000 55.84824  ? 27  VAL B C   1 
ATOM   2154 O  O   . VAL B 1 29  ? -9.23477  46.86290 -59.59205 1.000 55.89169  ? 27  VAL B O   1 
ATOM   2155 C  CB  . VAL B 1 29  ? -7.29750  44.12849 -59.73305 1.000 53.60080  ? 27  VAL B CB  1 
ATOM   2156 C  CG1 . VAL B 1 29  ? -8.54216  43.92302 -60.57420 1.000 59.69885  ? 27  VAL B CG1 1 
ATOM   2157 C  CG2 . VAL B 1 29  ? -6.03607  43.92045 -60.55076 1.000 54.37434  ? 27  VAL B CG2 1 
ATOM   2158 N  N   . LEU B 1 30  ? -9.33364  45.60086 -57.73162 1.000 50.87499  ? 28  LEU B N   1 
ATOM   2159 C  CA  . LEU B 1 30  ? -10.71011 45.95867 -57.40877 1.000 51.74949  ? 28  LEU B CA  1 
ATOM   2160 C  C   . LEU B 1 30  ? -10.84996 47.29947 -56.69115 1.000 57.46688  ? 28  LEU B C   1 
ATOM   2161 O  O   . LEU B 1 30  ? -11.98007 47.79699 -56.58912 1.000 49.72736  ? 28  LEU B O   1 
ATOM   2162 C  CB  . LEU B 1 30  ? -11.35061 44.85982 -56.54728 1.000 41.54651  ? 28  LEU B CB  1 
ATOM   2163 C  CG  . LEU B 1 30  ? -11.33124 43.46079 -57.17175 1.000 45.94246  ? 28  LEU B CG  1 
ATOM   2164 C  CD1 . LEU B 1 30  ? -11.76879 42.40571 -56.16047 1.000 44.99648  ? 28  LEU B CD1 1 
ATOM   2165 C  CD2 . LEU B 1 30  ? -12.19125 43.41400 -58.44838 1.000 46.00467  ? 28  LEU B CD2 1 
ATOM   2166 N  N   . HIS B 1 31  ? -9.74641  47.89224 -56.20767 1.000 48.46703  ? 29  HIS B N   1 
ATOM   2167 C  CA  . HIS B 1 31  ? -9.78465  49.08233 -55.34898 1.000 42.66959  ? 29  HIS B CA  1 
ATOM   2168 C  C   . HIS B 1 31  ? -10.62073 48.79562 -54.11663 1.000 47.82707  ? 29  HIS B C   1 
ATOM   2169 O  O   . HIS B 1 31  ? -11.38382 49.64458 -53.65790 1.000 52.14866  ? 29  HIS B O   1 
ATOM   2170 C  CB  . HIS B 1 31  ? -10.32967 50.32282 -56.06228 1.000 48.91236  ? 29  HIS B CB  1 
ATOM   2171 C  CG  . HIS B 1 31  ? -9.57908  50.71038 -57.29831 1.000 60.72263  ? 29  HIS B CG  1 
ATOM   2172 N  ND1 . HIS B 1 31  ? -9.32546  52.02402 -57.63020 1.000 69.43001  ? 29  HIS B ND1 1 
ATOM   2173 C  CD2 . HIS B 1 31  ? -9.03213  49.96157 -58.28624 1.000 62.37474  ? 29  HIS B CD2 1 
ATOM   2174 C  CE1 . HIS B 1 31  ? -8.66747  52.06831 -58.77540 1.000 66.10434  ? 29  HIS B CE1 1 
ATOM   2175 N  NE2 . HIS B 1 31  ? -8.46908  50.83027 -59.19076 1.000 67.28915  ? 29  HIS B NE2 1 
ATOM   2176 N  N   . LEU B 1 32  ? -10.46734 47.58165 -53.58121 1.000 47.60822  ? 30  LEU B N   1 
ATOM   2177 C  CA  . LEU B 1 32  ? -11.31173 47.12057 -52.48905 1.000 48.07228  ? 30  LEU B CA  1 
ATOM   2178 C  C   . LEU B 1 32  ? -11.11155 47.95009 -51.22566 1.000 50.81475  ? 30  LEU B C   1 
ATOM   2179 O  O   . LEU B 1 32  ? -12.07095 48.18005 -50.47866 1.000 57.20337  ? 30  LEU B O   1 
ATOM   2180 C  CB  . LEU B 1 32  ? -11.04596 45.63557 -52.23069 1.000 43.50274  ? 30  LEU B CB  1 
ATOM   2181 C  CG  . LEU B 1 32  ? -11.86711 44.93084 -51.15261 1.000 53.39296  ? 30  LEU B CG  1 
ATOM   2182 C  CD1 . LEU B 1 32  ? -13.34186 45.27159 -51.30390 1.000 54.08770  ? 30  LEU B CD1 1 
ATOM   2183 C  CD2 . LEU B 1 32  ? -11.68026 43.43055 -51.22385 1.000 52.88478  ? 30  LEU B CD2 1 
ATOM   2184 N  N   . THR B 1 33  ? -9.89280  48.42113 -50.97266 1.000 56.39888  ? 31  THR B N   1 
ATOM   2185 C  CA  . THR B 1 33  ? -9.65278  49.20759 -49.76548 1.000 54.47600  ? 31  THR B CA  1 
ATOM   2186 C  C   . THR B 1 33  ? -10.39607 50.54009 -49.82131 1.000 56.11033  ? 31  THR B C   1 
ATOM   2187 O  O   . THR B 1 33  ? -10.92122 51.00933 -48.80420 1.000 52.02417  ? 31  THR B O   1 
ATOM   2188 C  CB  . THR B 1 33  ? -8.14726  49.41981 -49.57236 1.000 54.64964  ? 31  THR B CB  1 
ATOM   2189 O  OG1 . THR B 1 33  ? -7.52645  48.14577 -49.37988 1.000 56.48715  ? 31  THR B OG1 1 
ATOM   2190 C  CG2 . THR B 1 33  ? -7.86160  50.29374 -48.34541 1.000 52.65124  ? 31  THR B CG2 1 
ATOM   2191 N  N   . ASP B 1 34  ? -10.46697 51.16135 -50.99998 1.000 52.82269  ? 32  ASP B N   1 
ATOM   2192 C  CA  . ASP B 1 34  ? -11.26723 52.37683 -51.12384 1.000 56.18055  ? 32  ASP B CA  1 
ATOM   2193 C  C   . ASP B 1 34  ? -12.74277 52.08089 -50.86538 1.000 62.88525  ? 32  ASP B C   1 
ATOM   2194 O  O   . ASP B 1 34  ? -13.42169 52.83630 -50.15986 1.000 63.89444  ? 32  ASP B O   1 
ATOM   2195 C  CB  . ASP B 1 34  ? -11.08062 52.98608 -52.51389 1.000 56.33622  ? 32  ASP B CB  1 
ATOM   2196 C  CG  . ASP B 1 34  ? -9.70911  53.62059 -52.70023 1.000 77.11654  ? 32  ASP B CG  1 
ATOM   2197 O  OD1 . ASP B 1 34  ? -9.00550  53.87485 -51.69501 1.000 84.19462  ? 32  ASP B OD1 1 
ATOM   2198 O  OD2 . ASP B 1 34  ? -9.31645  53.82055 -53.87239 1.000 88.68090  ? 32  ASP B OD2 1 
ATOM   2199 N  N   . ALA B 1 35  ? -13.25385 50.97529 -51.42284 1.000 54.21029  ? 33  ALA B N   1 
ATOM   2200 C  CA  . ALA B 1 35  ? -14.65559 50.62224 -51.22936 1.000 49.40227  ? 33  ALA B CA  1 
ATOM   2201 C  C   . ALA B 1 35  ? -14.95646 50.32276 -49.76181 1.000 54.72882  ? 33  ALA B C   1 
ATOM   2202 O  O   . ALA B 1 35  ? -15.95854 50.79520 -49.21187 1.000 56.28853  ? 33  ALA B O   1 
ATOM   2203 C  CB  . ALA B 1 35  ? -15.01603 49.43197 -52.11939 1.000 46.93521  ? 33  ALA B CB  1 
ATOM   2204 N  N   . LEU B 1 36  ? -14.10521 49.52527 -49.11060 1.000 51.11755  ? 34  LEU B N   1 
ATOM   2205 C  CA  . LEU B 1 36  ? -14.29981 49.24499 -47.69627 1.000 48.94161  ? 34  LEU B CA  1 
ATOM   2206 C  C   . LEU B 1 36  ? -14.09936 50.48905 -46.83180 1.000 54.40669  ? 34  LEU B C   1 
ATOM   2207 O  O   . LEU B 1 36  ? -14.60459 50.53983 -45.70258 1.000 52.78353  ? 34  LEU B O   1 
ATOM   2208 C  CB  . LEU B 1 36  ? -13.35800 48.12439 -47.25868 1.000 48.57852  ? 34  LEU B CB  1 
ATOM   2209 C  CG  . LEU B 1 36  ? -13.62261 46.75408 -47.89274 1.000 57.44158  ? 34  LEU B CG  1 
ATOM   2210 C  CD1 . LEU B 1 36  ? -12.57142 45.73747 -47.46092 1.000 47.48873  ? 34  LEU B CD1 1 
ATOM   2211 C  CD2 . LEU B 1 36  ? -15.01372 46.26628 -47.53470 1.000 51.02076  ? 34  LEU B CD2 1 
ATOM   2212 N  N   . GLY B 1 37  ? -13.39501 51.50032 -47.34101 1.000 49.45897  ? 35  GLY B N   1 
ATOM   2213 C  CA  . GLY B 1 37  ? -13.24121 52.73930 -46.60309 1.000 46.62694  ? 35  GLY B CA  1 
ATOM   2214 C  C   . GLY B 1 37  ? -14.53114 53.50244 -46.40838 1.000 58.51323  ? 35  GLY B C   1 
ATOM   2215 O  O   . GLY B 1 37  ? -14.61967 54.32022 -45.48897 1.000 61.25480  ? 35  GLY B O   1 
ATOM   2216 N  N   . ALA B 1 38  ? -15.54891 53.23212 -47.22870 1.000 59.19716  ? 36  ALA B N   1 
ATOM   2217 C  CA  . ALA B 1 38  ? -16.79221 53.97968 -47.12549 1.000 56.14499  ? 36  ALA B CA  1 
ATOM   2218 C  C   . ALA B 1 38  ? -17.66572 53.52718 -45.95421 1.000 52.67183  ? 36  ALA B C   1 
ATOM   2219 O  O   . ALA B 1 38  ? -18.53951 54.28342 -45.51922 1.000 53.29728  ? 36  ALA B O   1 
ATOM   2220 C  CB  . ALA B 1 38  ? -17.55716 53.88211 -48.44852 1.000 54.30262  ? 36  ALA B CB  1 
ATOM   2221 N  N   . LEU B 1 39  ? -17.44515 52.33510 -45.41534 1.000 52.47283  ? 37  LEU B N   1 
ATOM   2222 C  CA  . LEU B 1 39  ? -18.28312 51.86356 -44.32050 1.000 53.64630  ? 37  LEU B CA  1 
ATOM   2223 C  C   . LEU B 1 39  ? -18.12021 52.75806 -43.09667 1.000 62.17921  ? 37  LEU B C   1 
ATOM   2224 O  O   . LEU B 1 39  ? -17.00314 53.15599 -42.75033 1.000 63.12110  ? 37  LEU B O   1 
ATOM   2225 C  CB  . LEU B 1 39  ? -17.93044 50.41541 -43.98201 1.000 55.06172  ? 37  LEU B CB  1 
ATOM   2226 C  CG  . LEU B 1 39  ? -18.09572 49.48395 -45.19172 1.000 51.77943  ? 37  LEU B CG  1 
ATOM   2227 C  CD1 . LEU B 1 39  ? -17.74901 48.05964 -44.85911 1.000 57.16143  ? 37  LEU B CD1 1 
ATOM   2228 C  CD2 . LEU B 1 39  ? -19.50234 49.55643 -45.74215 1.000 51.06488  ? 37  LEU B CD2 1 
ATOM   2229 N  N   . VAL B 1 40  ? -19.24536 53.10714 -42.46391 1.000 59.16287  ? 38  VAL B N   1 
ATOM   2230 C  CA  . VAL B 1 40  ? -19.20781 53.89192 -41.22937 1.000 66.01551  ? 38  VAL B CA  1 
ATOM   2231 C  C   . VAL B 1 40  ? -18.30403 53.13652 -40.26167 1.000 66.84223  ? 38  VAL B C   1 
ATOM   2232 O  O   . VAL B 1 40  ? -18.51222 51.93714 -40.01035 1.000 63.24477  ? 38  VAL B O   1 
ATOM   2233 C  CB  . VAL B 1 40  ? -20.60965 54.15982 -40.63213 1.000 66.85255  ? 38  VAL B CB  1 
ATOM   2234 C  CG1 . VAL B 1 40  ? -21.46598 54.98369 -41.58971 1.000 67.50540  ? 38  VAL B CG1 1 
ATOM   2235 C  CG2 . VAL B 1 40  ? -21.33091 52.87252 -40.25673 1.000 66.13206  ? 38  VAL B CG2 1 
ATOM   2236 N  N   . PRO B 1 41  ? -17.24727 53.76823 -39.76046 1.000 75.74184  ? 39  PRO B N   1 
ATOM   2237 C  CA  . PRO B 1 41  ? -16.36788 53.07423 -38.80953 1.000 75.53940  ? 39  PRO B CA  1 
ATOM   2238 C  C   . PRO B 1 41  ? -17.17083 52.61398 -37.60313 1.000 70.56452  ? 39  PRO B C   1 
ATOM   2239 O  O   . PRO B 1 41  ? -18.14802 53.25185 -37.20452 1.000 71.26660  ? 39  PRO B O   1 
ATOM   2240 C  CB  . PRO B 1 41  ? -15.32368 54.13002 -38.43032 1.000 70.03934  ? 39  PRO B CB  1 
ATOM   2241 C  CG  . PRO B 1 41  ? -15.63285 55.35447 -39.22662 1.000 74.70150  ? 39  PRO B CG  1 
ATOM   2242 C  CD  . PRO B 1 41  ? -16.81337 55.13645 -40.09163 1.000 70.65700  ? 39  PRO B CD  1 
ATOM   2243 N  N   . GLU B 1 42  ? -16.77423 51.46891 -37.04088 1.000 77.30885  ? 40  GLU B N   1 
ATOM   2244 C  CA  . GLU B 1 42  ? -17.55608 50.89069 -35.94886 1.000 79.44505  ? 40  GLU B CA  1 
ATOM   2245 C  C   . GLU B 1 42  ? -17.45044 51.67866 -34.65008 1.000 78.54313  ? 40  GLU B C   1 
ATOM   2246 O  O   . GLU B 1 42  ? -18.20204 51.38803 -33.71350 1.000 76.41701  ? 40  GLU B O   1 
ATOM   2247 C  CB  . GLU B 1 42  ? -17.16777 49.43015 -35.72640 1.000 81.59344  ? 40  GLU B CB  1 
ATOM   2248 C  CG  . GLU B 1 42  ? -16.55852 48.77379 -36.95825 1.000 91.76901  ? 40  GLU B CG  1 
ATOM   2249 C  CD  . GLU B 1 42  ? -16.54132 47.25553 -36.85143 1.000 90.72024  ? 40  GLU B CD  1 
ATOM   2250 O  OE1 . GLU B 1 42  ? -16.66053 46.75601 -35.70405 1.000 86.14720  ? 40  GLU B OE1 1 
ATOM   2251 O  OE2 . GLU B 1 42  ? -16.42275 46.57529 -37.90847 1.000 83.20723  ? 40  GLU B OE2 1 
ATOM   2252 N  N   . SER B 1 43  ? -16.57481 52.68511 -34.58607 1.000 78.46345  ? 41  SER B N   1 
ATOM   2253 C  CA  . SER B 1 43  ? -16.52556 53.59956 -33.45284 1.000 78.96068  ? 41  SER B CA  1 
ATOM   2254 C  C   . SER B 1 43  ? -17.54039 54.73627 -33.55329 1.000 78.01031  ? 41  SER B C   1 
ATOM   2255 O  O   . SER B 1 43  ? -17.70299 55.48446 -32.58354 1.000 78.83584  ? 41  SER B O   1 
ATOM   2256 C  CB  . SER B 1 43  ? -15.11497 54.17786 -33.31727 1.000 77.97692  ? 41  SER B CB  1 
ATOM   2257 O  OG  . SER B 1 43  ? -14.51863 54.36238 -34.59089 1.000 84.97484  ? 41  SER B OG  1 
ATOM   2258 N  N   . GLU B 1 44  ? -18.22556 54.88388 -34.68947 1.000 77.03987  ? 42  GLU B N   1 
ATOM   2259 C  CA  . GLU B 1 44  ? -19.18712 55.96289 -34.89368 1.000 78.54824  ? 42  GLU B CA  1 
ATOM   2260 C  C   . GLU B 1 44  ? -20.59056 55.45842 -35.21435 1.000 80.97836  ? 42  GLU B C   1 
ATOM   2261 O  O   . GLU B 1 44  ? -21.45256 56.25981 -35.60778 1.000 81.55551  ? 42  GLU B O   1 
ATOM   2262 C  CB  . GLU B 1 44  ? -18.71122 56.89478 -36.01000 1.000 82.70748  ? 42  GLU B CB  1 
ATOM   2263 C  CG  . GLU B 1 44  ? -17.20640 56.96252 -36.16164 1.000 84.45996  ? 42  GLU B CG  1 
ATOM   2264 C  CD  . GLU B 1 44  ? -16.77135 58.01613 -37.16570 1.000 94.90680  ? 42  GLU B CD  1 
ATOM   2265 O  OE1 . GLU B 1 44  ? -17.29334 58.01507 -38.30384 1.000 97.85228  ? 42  GLU B OE1 1 
ATOM   2266 O  OE2 . GLU B 1 44  ? -15.90904 58.84919 -36.81265 1.000 98.01263  ? 42  GLU B OE2 1 
ATOM   2267 N  N   . THR B 1 45  ? -20.84406 54.15857 -35.06848 1.000 76.21225  ? 43  THR B N   1 
ATOM   2268 C  CA  . THR B 1 45  ? -22.17420 53.61935 -35.31646 1.000 80.98939  ? 43  THR B CA  1 
ATOM   2269 C  C   . THR B 1 45  ? -23.10454 53.99105 -34.16447 1.000 75.66568  ? 43  THR B C   1 
ATOM   2270 O  O   . THR B 1 45  ? -22.75492 53.82858 -32.99172 1.000 70.68087  ? 43  THR B O   1 
ATOM   2271 C  CB  . THR B 1 45  ? -22.11823 52.09609 -35.50929 1.000 76.90628  ? 43  THR B CB  1 
ATOM   2272 O  OG1 . THR B 1 45  ? -21.13888 51.51668 -34.63704 1.000 74.10922  ? 43  THR B OG1 1 
ATOM   2273 C  CG2 . THR B 1 45  ? -21.75535 51.75106 -36.94195 1.000 68.56539  ? 43  THR B CG2 1 
ATOM   2274 N  N   . GLU B 1 46  ? -24.27765 54.51838 -34.50051 1.000 74.75109  ? 44  GLU B N   1 
ATOM   2275 C  CA  . GLU B 1 46  ? -25.27080 54.88082 -33.49868 1.000 80.61411  ? 44  GLU B CA  1 
ATOM   2276 C  C   . GLU B 1 46  ? -26.21459 53.73760 -33.17645 1.000 75.64813  ? 44  GLU B C   1 
ATOM   2277 O  O   . GLU B 1 46  ? -27.08740 53.89314 -32.31530 1.000 80.28669  ? 44  GLU B O   1 
ATOM   2278 C  CB  . GLU B 1 46  ? -26.08288 56.09823 -33.96424 1.000 89.54123  ? 44  GLU B CB  1 
ATOM   2279 C  CG  . GLU B 1 46  ? -25.24988 57.22089 -34.58708 1.000 98.32376  ? 44  GLU B CG  1 
ATOM   2280 C  CD  . GLU B 1 46  ? -24.44821 58.03315 -33.56399 1.000 106.68294 ? 44  GLU B CD  1 
ATOM   2281 O  OE1 . GLU B 1 46  ? -23.84951 57.44059 -32.63192 1.000 102.96969 ? 44  GLU B OE1 1 
ATOM   2282 O  OE2 . GLU B 1 46  ? -24.41773 59.27786 -33.69924 1.000 108.69817 ? 44  GLU B OE2 1 
ATOM   2283 N  N   . HIS B 1 47  ? -26.05483 52.60490 -33.84218 1.000 67.34442  ? 45  HIS B N   1 
ATOM   2284 C  CA  . HIS B 1 47  ? -26.95815 51.47769 -33.71143 1.000 55.62747  ? 45  HIS B CA  1 
ATOM   2285 C  C   . HIS B 1 47  ? -26.32018 50.25960 -34.36473 1.000 55.18027  ? 45  HIS B C   1 
ATOM   2286 O  O   . HIS B 1 47  ? -25.63024 50.38682 -35.38648 1.000 51.42785  ? 45  HIS B O   1 
ATOM   2287 C  CB  . HIS B 1 47  ? -28.31239 51.78699 -34.34451 1.000 56.73238  ? 45  HIS B CB  1 
ATOM   2288 C  CG  . HIS B 1 47  ? -29.40027 50.86417 -33.89702 1.000 61.66425  ? 45  HIS B CG  1 
ATOM   2289 N  ND1 . HIS B 1 47  ? -29.52708 49.57654 -34.37644 1.000 54.58523  ? 45  HIS B ND1 1 
ATOM   2290 C  CD2 . HIS B 1 47  ? -30.39676 51.03136 -32.99296 1.000 56.95604  ? 45  HIS B CD2 1 
ATOM   2291 C  CE1 . HIS B 1 47  ? -30.55556 48.98994 -33.78509 1.000 58.68694  ? 45  HIS B CE1 1 
ATOM   2292 N  NE2 . HIS B 1 47  ? -31.10210 49.85124 -32.94283 1.000 58.69924  ? 45  HIS B NE2 1 
ATOM   2293 N  N   . PRO B 1 48  ? -26.49555 49.07311 -33.78302 1.000 49.19256  ? 46  PRO B N   1 
ATOM   2294 C  CA  . PRO B 1 48  ? -25.93697 47.86163 -34.40254 1.000 53.49361  ? 46  PRO B CA  1 
ATOM   2295 C  C   . PRO B 1 48  ? -26.48889 47.58059 -35.79664 1.000 51.83220  ? 46  PRO B C   1 
ATOM   2296 O  O   . PRO B 1 48  ? -25.83087 46.88790 -36.58591 1.000 49.25967  ? 46  PRO B O   1 
ATOM   2297 C  CB  . PRO B 1 48  ? -26.31977 46.74608 -33.41823 1.000 48.96808  ? 46  PRO B CB  1 
ATOM   2298 C  CG  . PRO B 1 48  ? -26.78122 47.42381 -32.19214 1.000 50.65576  ? 46  PRO B CG  1 
ATOM   2299 C  CD  . PRO B 1 48  ? -27.15574 48.81334 -32.49353 1.000 48.80341  ? 46  PRO B CD  1 
ATOM   2300 N  N   . ASP B 1 49  ? -27.66907 48.08887 -36.12722 1.000 48.00959  ? 47  ASP B N   1 
ATOM   2301 C  CA  . ASP B 1 49  ? -28.26324 47.81490 -37.42210 1.000 44.54755  ? 47  ASP B CA  1 
ATOM   2302 C  C   . ASP B 1 49  ? -27.89691 48.85824 -38.47709 1.000 42.54357  ? 47  ASP B C   1 
ATOM   2303 O  O   . ASP B 1 49  ? -28.32826 48.72679 -39.62289 1.000 41.89477  ? 47  ASP B O   1 
ATOM   2304 C  CB  . ASP B 1 49  ? -29.78934 47.69308 -37.27744 1.000 40.02713  ? 47  ASP B CB  1 
ATOM   2305 C  CG  . ASP B 1 49  ? -30.22261 46.37301 -36.60372 1.000 43.37428  ? 47  ASP B CG  1 
ATOM   2306 O  OD1 . ASP B 1 49  ? -29.64093 45.30552 -36.88066 1.000 46.63366  ? 47  ASP B OD1 1 
ATOM   2307 O  OD2 . ASP B 1 49  ? -31.14781 46.39307 -35.76929 1.000 48.24417  ? 47  ASP B OD2 1 
ATOM   2308 N  N   . GLN B 1 50  ? -27.08503 49.86427 -38.14417 1.000 38.28732  ? 48  GLN B N   1 
ATOM   2309 C  CA  . GLN B 1 50  ? -26.78477 50.91776 -39.11702 1.000 44.09221  ? 48  GLN B CA  1 
ATOM   2310 C  C   . GLN B 1 50  ? -25.94279 50.41049 -40.29723 1.000 44.26276  ? 48  GLN B C   1 
ATOM   2311 O  O   . GLN B 1 50  ? -26.18865 50.79805 -41.45016 1.000 45.30924  ? 48  GLN B O   1 
ATOM   2312 C  CB  . GLN B 1 50  ? -26.08412 52.07857 -38.42726 1.000 47.78096  ? 48  GLN B CB  1 
ATOM   2313 C  CG  . GLN B 1 50  ? -25.80041 53.22624 -39.37203 1.000 57.95357  ? 48  GLN B CG  1 
ATOM   2314 C  CD  . GLN B 1 50  ? -24.94429 54.30932 -38.73442 1.000 68.67806  ? 48  GLN B CD  1 
ATOM   2315 O  OE1 . GLN B 1 50  ? -24.73031 54.31877 -37.51739 1.000 66.63275  ? 48  GLN B OE1 1 
ATOM   2316 N  NE2 . GLN B 1 50  ? -24.46037 55.23752 -39.55749 1.000 73.87649  ? 48  GLN B NE2 1 
ATOM   2317 N  N   . ARG B 1 51  ? -24.94554 49.55848 -40.03040 1.000 38.47940  ? 49  ARG B N   1 
ATOM   2318 C  CA  . ARG B 1 51  ? -24.11953 48.97803 -41.09098 1.000 40.10333  ? 49  ARG B CA  1 
ATOM   2319 C  C   . ARG B 1 51  ? -24.96543 48.25615 -42.13175 1.000 42.76224  ? 49  ARG B C   1 
ATOM   2320 O  O   . ARG B 1 51  ? -24.77865 48.43119 -43.34385 1.000 43.14833  ? 49  ARG B O   1 
ATOM   2321 C  CB  . ARG B 1 51  ? -23.12549 47.99735 -40.48186 1.000 43.88257  ? 49  ARG B CB  1 
ATOM   2322 C  CG  . ARG B 1 51  ? -21.88004 48.64755 -39.99158 1.000 52.88488  ? 49  ARG B CG  1 
ATOM   2323 C  CD  . ARG B 1 51  ? -21.09848 49.25351 -41.14715 1.000 52.18532  ? 49  ARG B CD  1 
ATOM   2324 N  NE  . ARG B 1 51  ? -19.69896 49.30906 -40.76691 1.000 64.66526  ? 49  ARG B NE  1 
ATOM   2325 C  CZ  . ARG B 1 51  ? -18.92390 48.24612 -40.59465 1.000 69.56122  ? 49  ARG B CZ  1 
ATOM   2326 N  NH1 . ARG B 1 51  ? -19.31803 47.02981 -40.95615 1.000 63.42055  ? 49  ARG B NH1 1 
ATOM   2327 N  NH2 . ARG B 1 51  ? -17.72659 48.40695 -40.04089 1.000 72.04298  ? 49  ARG B NH2 1 
ATOM   2328 N  N   . PHE B 1 52  ? -25.86972 47.40254 -41.66186 1.000 38.05110  ? 50  PHE B N   1 
ATOM   2329 C  CA  . PHE B 1 52  ? -26.77145 46.66234 -42.52698 1.000 41.27606  ? 50  PHE B CA  1 
ATOM   2330 C  C   . PHE B 1 52  ? -27.56228 47.60966 -43.41660 1.000 43.45962  ? 50  PHE B C   1 
ATOM   2331 O  O   . PHE B 1 52  ? -27.63098 47.42935 -44.64085 1.000 38.84746  ? 50  PHE B O   1 
ATOM   2332 C  CB  . PHE B 1 52  ? -27.69111 45.81569 -41.64353 1.000 36.92572  ? 50  PHE B CB  1 
ATOM   2333 C  CG  . PHE B 1 52  ? -28.65287 44.96833 -42.40163 1.000 44.96612  ? 50  PHE B CG  1 
ATOM   2334 C  CD1 . PHE B 1 52  ? -28.20726 44.09451 -43.38354 1.000 44.37284  ? 50  PHE B CD1 1 
ATOM   2335 C  CD2 . PHE B 1 52  ? -30.01487 45.01884 -42.11417 1.000 44.00502  ? 50  PHE B CD2 1 
ATOM   2336 C  CE1 . PHE B 1 52  ? -29.11261 43.30216 -44.08423 1.000 46.97226  ? 50  PHE B CE1 1 
ATOM   2337 C  CE2 . PHE B 1 52  ? -30.93285 44.22082 -42.80424 1.000 40.70420  ? 50  PHE B CE2 1 
ATOM   2338 C  CZ  . PHE B 1 52  ? -30.48331 43.36641 -43.79127 1.000 45.67999  ? 50  PHE B CZ  1 
ATOM   2339 N  N   . PHE B 1 53  ? -28.15430 48.64079 -42.80663 1.000 39.50547  ? 51  PHE B N   1 
ATOM   2340 C  CA  . PHE B 1 53  ? -28.80549 49.71164 -43.55692 1.000 41.15348  ? 51  PHE B CA  1 
ATOM   2341 C  C   . PHE B 1 53  ? -27.86824 50.28265 -44.62296 1.000 42.42045  ? 51  PHE B C   1 
ATOM   2342 O  O   . PHE B 1 53  ? -28.23001 50.38357 -45.80132 1.000 40.16999  ? 51  PHE B O   1 
ATOM   2343 C  CB  . PHE B 1 53  ? -29.26103 50.79023 -42.56082 1.000 48.62902  ? 51  PHE B CB  1 
ATOM   2344 C  CG  . PHE B 1 53  ? -29.98175 51.97373 -43.17387 1.000 51.85396  ? 51  PHE B CG  1 
ATOM   2345 C  CD1 . PHE B 1 53  ? -29.27567 53.09652 -43.60557 1.000 50.47745  ? 51  PHE B CD1 1 
ATOM   2346 C  CD2 . PHE B 1 53  ? -31.36952 51.99783 -43.24384 1.000 53.03888  ? 51  PHE B CD2 1 
ATOM   2347 C  CE1 . PHE B 1 53  ? -29.94194 54.20208 -44.13876 1.000 52.02475  ? 51  PHE B CE1 1 
ATOM   2348 C  CE2 . PHE B 1 53  ? -32.04251 53.09974 -43.77483 1.000 50.41016  ? 51  PHE B CE2 1 
ATOM   2349 C  CZ  . PHE B 1 53  ? -31.32532 54.20285 -44.22180 1.000 49.08351  ? 51  PHE B CZ  1 
ATOM   2350 N  N   . GLN B 1 54  ? -26.64300 50.63619 -44.22679 1.000 45.08771  ? 52  GLN B N   1 
ATOM   2351 C  CA  . GLN B 1 54  ? -25.71477 51.26489 -45.16087 1.000 44.95263  ? 52  GLN B CA  1 
ATOM   2352 C  C   . GLN B 1 54  ? -25.36492 50.33163 -46.31594 1.000 44.65573  ? 52  GLN B C   1 
ATOM   2353 O  O   . GLN B 1 54  ? -25.44102 50.71932 -47.49012 1.000 42.29108  ? 52  GLN B O   1 
ATOM   2354 C  CB  . GLN B 1 54  ? -24.43900 51.70709 -44.43560 1.000 39.10803  ? 52  GLN B CB  1 
ATOM   2355 C  CG  . GLN B 1 54  ? -23.51428 52.50299 -45.36484 1.000 44.90858  ? 52  GLN B CG  1 
ATOM   2356 C  CD  . GLN B 1 54  ? -22.11783 52.73679 -44.80826 1.000 50.29941  ? 52  GLN B CD  1 
ATOM   2357 O  OE1 . GLN B 1 54  ? -21.71254 52.12322 -43.82570 1.000 51.93418  ? 52  GLN B OE1 1 
ATOM   2358 N  NE2 . GLN B 1 54  ? -21.38558 53.65605 -45.42823 1.000 50.72071  ? 52  GLN B NE2 1 
ATOM   2359 N  N   . VAL B 1 55  ? -24.99031 49.09117 -45.99852 1.000 38.60203  ? 53  VAL B N   1 
ATOM   2360 C  CA  . VAL B 1 55  ? -24.44812 48.18903 -47.01083 1.000 38.12026  ? 53  VAL B CA  1 
ATOM   2361 C  C   . VAL B 1 55  ? -25.48693 47.87397 -48.07884 1.000 40.75238  ? 53  VAL B C   1 
ATOM   2362 O  O   . VAL B 1 55  ? -25.14840 47.75006 -49.26356 1.000 39.22975  ? 53  VAL B O   1 
ATOM   2363 C  CB  . VAL B 1 55  ? -23.90015 46.91388 -46.33982 1.000 41.51826  ? 53  VAL B CB  1 
ATOM   2364 C  CG1 . VAL B 1 55  ? -23.83880 45.75646 -47.31166 1.000 39.55929  ? 53  VAL B CG1 1 
ATOM   2365 C  CG2 . VAL B 1 55  ? -22.51582 47.19153 -45.79999 1.000 46.08423  ? 53  VAL B CG2 1 
ATOM   2366 N  N   . THR B 1 56  ? -26.76564 47.73851 -47.68839 1.000 37.02910  ? 54  THR B N   1 
ATOM   2367 C  CA  . THR B 1 56  ? -27.79236 47.45790 -48.69212 1.000 41.55514  ? 54  THR B CA  1 
ATOM   2368 C  C   . THR B 1 56  ? -27.97965 48.63023 -49.64878 1.000 38.32851  ? 54  THR B C   1 
ATOM   2369 O  O   . THR B 1 56  ? -28.23938 48.40920 -50.83471 1.000 39.45322  ? 54  THR B O   1 
ATOM   2370 C  CB  . THR B 1 56  ? -29.13299 47.09612 -48.05216 1.000 38.76721  ? 54  THR B CB  1 
ATOM   2371 O  OG1 . THR B 1 56  ? -29.57803 48.18198 -47.24214 1.000 48.28186  ? 54  THR B OG1 1 
ATOM   2372 C  CG2 . THR B 1 56  ? -29.01712 45.84708 -47.19570 1.000 41.24279  ? 54  THR B CG2 1 
ATOM   2373 N  N   . HIS B 1 57  ? -27.82172 49.86933 -49.17068 1.000 39.55784  ? 55  HIS B N   1 
ATOM   2374 C  CA  . HIS B 1 57  ? -27.82749 51.02142 -50.07340 1.000 38.24681  ? 55  HIS B CA  1 
ATOM   2375 C  C   . HIS B 1 57  ? -26.64043 50.98063 -51.03048 1.000 40.58106  ? 55  HIS B C   1 
ATOM   2376 O  O   . HIS B 1 57  ? -26.78465 51.26409 -52.22864 1.000 39.84168  ? 55  HIS B O   1 
ATOM   2377 C  CB  . HIS B 1 57  ? -27.78509 52.33182 -49.28753 1.000 39.91415  ? 55  HIS B CB  1 
ATOM   2378 C  CG  . HIS B 1 57  ? -29.10015 52.74809 -48.72024 1.000 46.13911  ? 55  HIS B CG  1 
ATOM   2379 N  ND1 . HIS B 1 57  ? -29.61914 52.19715 -47.56723 1.000 46.45156  ? 55  HIS B ND1 1 
ATOM   2380 C  CD2 . HIS B 1 57  ? -30.00207 53.66718 -49.14024 1.000 45.62071  ? 55  HIS B CD2 1 
ATOM   2381 C  CE1 . HIS B 1 57  ? -30.78436 52.76128 -47.30006 1.000 47.43260  ? 55  HIS B CE1 1 
ATOM   2382 N  NE2 . HIS B 1 57  ? -31.04382 53.65045 -48.24268 1.000 47.58902  ? 55  HIS B NE2 1 
ATOM   2383 N  N   . LEU B 1 58  ? -25.44796 50.67276 -50.50701 1.000 37.20283  ? 56  LEU B N   1 
ATOM   2384 C  CA  . LEU B 1 58  ? -24.25024 50.70007 -51.33582 1.000 39.47689  ? 56  LEU B CA  1 
ATOM   2385 C  C   . LEU B 1 58  ? -24.31075 49.62926 -52.41414 1.000 37.73961  ? 56  LEU B C   1 
ATOM   2386 O  O   . LEU B 1 58  ? -23.98928 49.89038 -53.57951 1.000 40.42235  ? 56  LEU B O   1 
ATOM   2387 C  CB  . LEU B 1 58  ? -23.00589 50.52438 -50.46913 1.000 41.21099  ? 56  LEU B CB  1 
ATOM   2388 C  CG  . LEU B 1 58  ? -22.70371 51.66838 -49.49888 1.000 47.52748  ? 56  LEU B CG  1 
ATOM   2389 C  CD1 . LEU B 1 58  ? -21.36817 51.43960 -48.84367 1.000 45.95213  ? 56  LEU B CD1 1 
ATOM   2390 C  CD2 . LEU B 1 58  ? -22.74076 53.03106 -50.18040 1.000 44.32655  ? 56  LEU B CD2 1 
ATOM   2391 N  N   . ILE B 1 59  ? -24.74643 48.42455 -52.05129 1.000 38.82675  ? 57  ILE B N   1 
ATOM   2392 C  CA  . ILE B 1 59  ? -24.92937 47.37457 -53.04756 1.000 36.82987  ? 57  ILE B CA  1 
ATOM   2393 C  C   . ILE B 1 59  ? -25.88742 47.83616 -54.14071 1.000 35.59252  ? 57  ILE B C   1 
ATOM   2394 O  O   . ILE B 1 59  ? -25.62695 47.65140 -55.33448 1.000 36.69807  ? 57  ILE B O   1 
ATOM   2395 C  CB  . ILE B 1 59  ? -25.41272 46.08899 -52.35977 1.000 39.30219  ? 57  ILE B CB  1 
ATOM   2396 C  CG1 . ILE B 1 59  ? -24.22428 45.43878 -51.65322 1.000 36.60152  ? 57  ILE B CG1 1 
ATOM   2397 C  CG2 . ILE B 1 59  ? -26.08842 45.15952 -53.36165 1.000 33.20798  ? 57  ILE B CG2 1 
ATOM   2398 C  CD1 . ILE B 1 59  ? -24.59471 44.30320 -50.74635 1.000 37.04065  ? 57  ILE B CD1 1 
ATOM   2399 N  N   . THR B 1 60  ? -26.98591 48.48294 -53.75385 1.000 34.77395  ? 58  THR B N   1 
ATOM   2400 C  CA  . THR B 1 60  ? -27.92811 48.99335 -54.73999 1.000 34.93066  ? 58  THR B CA  1 
ATOM   2401 C  C   . THR B 1 60  ? -27.27904 50.03306 -55.62922 1.000 36.03358  ? 58  THR B C   1 
ATOM   2402 O  O   . THR B 1 60  ? -27.41004 49.98336 -56.86171 1.000 34.93534  ? 58  THR B O   1 
ATOM   2403 C  CB  . THR B 1 60  ? -29.14959 49.60096 -54.04897 1.000 37.27236  ? 58  THR B CB  1 
ATOM   2404 O  OG1 . THR B 1 60  ? -29.82666 48.58265 -53.31471 1.000 36.54649  ? 58  THR B OG1 1 
ATOM   2405 C  CG2 . THR B 1 60  ? -30.09714 50.19334 -55.08481 1.000 31.12216  ? 58  THR B CG2 1 
ATOM   2406 N  N   . GLU B 1 61  ? -26.58587 51.00445 -55.02156 1.000 37.22206  ? 59  GLU B N   1 
ATOM   2407 C  CA  . GLU B 1 61  ? -26.00974 52.06711 -55.83004 1.000 35.90244  ? 59  GLU B CA  1 
ATOM   2408 C  C   . GLU B 1 61  ? -24.95874 51.51082 -56.78666 1.000 39.61181  ? 59  GLU B C   1 
ATOM   2409 O  O   . GLU B 1 61  ? -24.87791 51.93973 -57.94022 1.000 40.64385  ? 59  GLU B O   1 
ATOM   2410 C  CB  . GLU B 1 61  ? -25.44514 53.17549 -54.94076 1.000 37.84949  ? 59  GLU B CB  1 
ATOM   2411 C  CG  . GLU B 1 61  ? -26.53759 53.98381 -54.16633 1.000 44.80708  ? 59  GLU B CG  1 
ATOM   2412 C  CD  . GLU B 1 61  ? -27.42669 54.91060 -55.03423 1.000 47.75566  ? 59  GLU B CD  1 
ATOM   2413 O  OE1 . GLU B 1 61  ? -27.07081 55.23630 -56.18828 1.000 49.82033  ? 59  GLU B OE1 1 
ATOM   2414 O  OE2 . GLU B 1 61  ? -28.49445 55.34510 -54.54359 1.000 47.66111  ? 59  GLU B OE2 1 
ATOM   2415 N  N   . TYR B 1 62  ? -24.18601 50.51011 -56.35163 1.000 43.06998  ? 60  TYR B N   1 
ATOM   2416 C  CA  . TYR B 1 62  ? -23.23843 49.87718 -57.26501 1.000 39.36082  ? 60  TYR B CA  1 
ATOM   2417 C  C   . TYR B 1 62  ? -23.95099 49.20339 -58.42633 1.000 37.56534  ? 60  TYR B C   1 
ATOM   2418 O  O   . TYR B 1 62  ? -23.50540 49.29165 -59.57622 1.000 39.83081  ? 60  TYR B O   1 
ATOM   2419 C  CB  . TYR B 1 62  ? -22.37754 48.86041 -56.52598 1.000 40.74678  ? 60  TYR B CB  1 
ATOM   2420 C  CG  . TYR B 1 62  ? -21.09812 49.43520 -55.99224 1.000 43.92997  ? 60  TYR B CG  1 
ATOM   2421 C  CD1 . TYR B 1 62  ? -20.40802 50.41448 -56.67976 1.000 54.93452  ? 60  TYR B CD1 1 
ATOM   2422 C  CD2 . TYR B 1 62  ? -20.58749 49.01032 -54.79092 1.000 54.42887  ? 60  TYR B CD2 1 
ATOM   2423 C  CE1 . TYR B 1 62  ? -19.23677 50.94768 -56.17089 1.000 60.72429  ? 60  TYR B CE1 1 
ATOM   2424 C  CE2 . TYR B 1 62  ? -19.42695 49.53139 -54.29285 1.000 57.49088  ? 60  TYR B CE2 1 
ATOM   2425 C  CZ  . TYR B 1 62  ? -18.76227 50.48967 -54.96857 1.000 50.35315  ? 60  TYR B CZ  1 
ATOM   2426 O  OH  . TYR B 1 62  ? -17.60824 50.97160 -54.41582 1.000 56.85480  ? 60  TYR B OH  1 
ATOM   2427 N  N   . ALA B 1 63  ? -25.04580 48.50398 -58.15397 1.000 36.95484  ? 61  ALA B N   1 
ATOM   2428 C  CA  . ALA B 1 63  ? -25.74607 47.85394 -59.25612 1.000 37.16133  ? 61  ALA B CA  1 
ATOM   2429 C  C   . ALA B 1 63  ? -26.33931 48.88426 -60.21366 1.000 37.53764  ? 61  ALA B C   1 
ATOM   2430 O  O   . ALA B 1 63  ? -26.28441 48.70698 -61.44189 1.000 37.61707  ? 61  ALA B O   1 
ATOM   2431 C  CB  . ALA B 1 63  ? -26.82405 46.91384 -58.71552 1.000 32.56622  ? 61  ALA B CB  1 
ATOM   2432 N  N   . TRP B 1 64  ? -26.86883 49.98619 -59.67372 1.000 33.98212  ? 62  TRP B N   1 
ATOM   2433 C  CA  . TRP B 1 64  ? -27.49438 50.99854 -60.52198 1.000 36.80909  ? 62  TRP B CA  1 
ATOM   2434 C  C   . TRP B 1 64  ? -26.46733 51.73104 -61.37980 1.000 39.91148  ? 62  TRP B C   1 
ATOM   2435 O  O   . TRP B 1 64  ? -26.76133 52.09357 -62.53218 1.000 36.86839  ? 62  TRP B O   1 
ATOM   2436 C  CB  . TRP B 1 64  ? -28.29278 51.99726 -59.67291 1.000 34.40420  ? 62  TRP B CB  1 
ATOM   2437 C  CG  . TRP B 1 64  ? -29.69244 51.52433 -59.36859 1.000 39.02577  ? 62  TRP B CG  1 
ATOM   2438 C  CD1 . TRP B 1 64  ? -30.40008 50.57365 -60.04341 1.000 35.79313  ? 62  TRP B CD1 1 
ATOM   2439 C  CD2 . TRP B 1 64  ? -30.54779 51.98717 -58.31300 1.000 34.73687  ? 62  TRP B CD2 1 
ATOM   2440 N  NE1 . TRP B 1 64  ? -31.63739 50.41215 -59.47184 1.000 36.51985  ? 62  TRP B NE1 1 
ATOM   2441 C  CE2 . TRP B 1 64  ? -31.75392 51.27146 -58.41190 1.000 36.53784  ? 62  TRP B CE2 1 
ATOM   2442 C  CE3 . TRP B 1 64  ? -30.40976 52.94773 -57.30244 1.000 35.49187  ? 62  TRP B CE3 1 
ATOM   2443 C  CZ2 . TRP B 1 64  ? -32.81467 51.47193 -57.53064 1.000 38.90790  ? 62  TRP B CZ2 1 
ATOM   2444 C  CZ3 . TRP B 1 64  ? -31.45519 53.15465 -56.43865 1.000 38.44684  ? 62  TRP B CZ3 1 
ATOM   2445 C  CH2 . TRP B 1 64  ? -32.64833 52.42107 -56.55405 1.000 44.02048  ? 62  TRP B CH2 1 
ATOM   2446 N  N   . VAL B 1 65  ? -25.26482 51.98033 -60.84553 1.000 34.99674  ? 63  VAL B N   1 
ATOM   2447 C  CA  . VAL B 1 65  ? -24.28198 52.66131 -61.68696 1.000 41.98833  ? 63  VAL B CA  1 
ATOM   2448 C  C   . VAL B 1 65  ? -23.85661 51.72930 -62.81429 1.000 37.29934  ? 63  VAL B C   1 
ATOM   2449 O  O   . VAL B 1 65  ? -23.68753 52.16056 -63.96039 1.000 39.24903  ? 63  VAL B O   1 
ATOM   2450 C  CB  . VAL B 1 65  ? -23.08540 53.18647 -60.86001 1.000 44.79939  ? 63  VAL B CB  1 
ATOM   2451 C  CG1 . VAL B 1 65  ? -22.28640 52.04709 -60.26748 1.000 48.95514  ? 63  VAL B CG1 1 
ATOM   2452 C  CG2 . VAL B 1 65  ? -22.17636 54.04584 -61.73423 1.000 45.69654  ? 63  VAL B CG2 1 
ATOM   2453 N  N   . GLN B 1 66  ? -23.79262 50.42952 -62.54227 1.000 33.63726  ? 64  GLN B N   1 
ATOM   2454 C  CA  . GLN B 1 66  ? -23.48174 49.48000 -63.60118 1.000 32.11698  ? 64  GLN B CA  1 
ATOM   2455 C  C   . GLN B 1 66  ? -24.61366 49.36622 -64.61173 1.000 38.30972  ? 64  GLN B C   1 
ATOM   2456 O  O   . GLN B 1 66  ? -24.35788 49.17584 -65.80679 1.000 40.79380  ? 64  GLN B O   1 
ATOM   2457 C  CB  . GLN B 1 66  ? -23.17032 48.11758 -63.00305 1.000 34.26396  ? 64  GLN B CB  1 
ATOM   2458 C  CG  . GLN B 1 66  ? -22.48530 47.17157 -63.96018 1.000 41.99019  ? 64  GLN B CG  1 
ATOM   2459 C  CD  . GLN B 1 66  ? -21.26318 47.79237 -64.63252 1.000 48.37740  ? 64  GLN B CD  1 
ATOM   2460 O  OE1 . GLN B 1 66  ? -20.49959 48.54490 -64.00799 1.000 49.67580  ? 64  GLN B OE1 1 
ATOM   2461 N  NE2 . GLN B 1 66  ? -21.07614 47.47897 -65.91343 1.000 41.06289  ? 64  GLN B NE2 1 
ATOM   2462 N  N   . VAL B 1 67  ? -25.87170 49.44486 -64.15785 1.000 38.10762  ? 65  VAL B N   1 
ATOM   2463 C  CA  . VAL B 1 67  ? -26.99533 49.43313 -65.09966 1.000 38.41825  ? 65  VAL B CA  1 
ATOM   2464 C  C   . VAL B 1 67  ? -26.87243 50.60895 -66.05897 1.000 41.18049  ? 65  VAL B C   1 
ATOM   2465 O  O   . VAL B 1 67  ? -27.02049 50.46202 -67.27850 1.000 41.56799  ? 65  VAL B O   1 
ATOM   2466 C  CB  . VAL B 1 67  ? -28.34879 49.46855 -64.35475 1.000 38.10912  ? 65  VAL B CB  1 
ATOM   2467 C  CG1 . VAL B 1 67  ? -29.50042 49.75453 -65.32706 1.000 30.84670  ? 65  VAL B CG1 1 
ATOM   2468 C  CG2 . VAL B 1 67  ? -28.61568 48.16185 -63.62647 1.000 31.35874  ? 65  VAL B CG2 1 
ATOM   2469 N  N   . HIS B 1 68  ? -26.59922 51.79696 -65.51231 1.000 34.86677  ? 66  HIS B N   1 
ATOM   2470 C  CA  . HIS B 1 68  ? -26.36908 52.97621 -66.34048 1.000 38.07218  ? 66  HIS B CA  1 
ATOM   2471 C  C   . HIS B 1 68  ? -25.30058 52.71114 -67.39846 1.000 42.32782  ? 66  HIS B C   1 
ATOM   2472 O  O   . HIS B 1 68  ? -25.53082 52.91023 -68.59775 1.000 42.52652  ? 66  HIS B O   1 
ATOM   2473 C  CB  . HIS B 1 68  ? -25.96236 54.15187 -65.45591 1.000 32.31438  ? 66  HIS B CB  1 
ATOM   2474 C  CG  . HIS B 1 68  ? -25.97066 55.46131 -66.16670 1.000 44.59063  ? 66  HIS B CG  1 
ATOM   2475 N  ND1 . HIS B 1 68  ? -24.87565 55.93917 -66.85261 1.000 53.09234  ? 66  HIS B ND1 1 
ATOM   2476 C  CD2 . HIS B 1 68  ? -26.94269 56.39274 -66.31063 1.000 51.62970  ? 66  HIS B CD2 1 
ATOM   2477 C  CE1 . HIS B 1 68  ? -25.17309 57.10899 -67.38969 1.000 54.63668  ? 66  HIS B CE1 1 
ATOM   2478 N  NE2 . HIS B 1 68  ? -26.42044 57.40690 -67.07721 1.000 56.71085  ? 66  HIS B NE2 1 
ATOM   2479 N  N   . TYR B 1 69  ? -24.12430 52.24869 -66.96026 1.000 40.75748  ? 67  TYR B N   1 
ATOM   2480 C  CA  . TYR B 1 69  ? -23.02217 51.93558 -67.86978 1.000 41.61662  ? 67  TYR B CA  1 
ATOM   2481 C  C   . TYR B 1 69  ? -23.46733 51.03268 -69.02129 1.000 44.05927  ? 67  TYR B C   1 
ATOM   2482 O  O   . TYR B 1 69  ? -23.20368 51.32507 -70.19556 1.000 43.33203  ? 67  TYR B O   1 
ATOM   2483 C  CB  . TYR B 1 69  ? -21.89605 51.27795 -67.07337 1.000 46.15149  ? 67  TYR B CB  1 
ATOM   2484 C  CG  . TYR B 1 69  ? -20.60302 51.11085 -67.81727 1.000 50.85893  ? 67  TYR B CG  1 
ATOM   2485 C  CD1 . TYR B 1 69  ? -19.64784 52.12450 -67.81736 1.000 53.10796  ? 67  TYR B CD1 1 
ATOM   2486 C  CD2 . TYR B 1 69  ? -20.31445 49.92543 -68.49920 1.000 48.68419  ? 67  TYR B CD2 1 
ATOM   2487 C  CE1 . TYR B 1 69  ? -18.45172 51.97689 -68.48443 1.000 54.16829  ? 67  TYR B CE1 1 
ATOM   2488 C  CE2 . TYR B 1 69  ? -19.11094 49.76876 -69.17844 1.000 47.70447  ? 67  TYR B CE2 1 
ATOM   2489 C  CZ  . TYR B 1 69  ? -18.18815 50.80423 -69.16652 1.000 56.18920  ? 67  TYR B CZ  1 
ATOM   2490 O  OH  . TYR B 1 69  ? -16.99047 50.67623 -69.83341 1.000 67.79673  ? 67  TYR B OH  1 
ATOM   2491 N  N   . GLU B 1 70  ? -24.16294 49.93400 -68.70232 1.000 38.97468  ? 68  GLU B N   1 
ATOM   2492 C  CA  . GLU B 1 70  ? -24.57285 48.98903 -69.74128 1.000 39.03929  ? 68  GLU B CA  1 
ATOM   2493 C  C   . GLU B 1 70  ? -25.64579 49.57616 -70.65749 1.000 42.28769  ? 68  GLU B C   1 
ATOM   2494 O  O   . GLU B 1 70  ? -25.72376 49.20657 -71.83552 1.000 41.81355  ? 68  GLU B O   1 
ATOM   2495 C  CB  . GLU B 1 70  ? -25.05310 47.67492 -69.09954 1.000 37.31023  ? 68  GLU B CB  1 
ATOM   2496 C  CG  . GLU B 1 70  ? -24.04696 47.03429 -68.11802 1.000 41.38430  ? 68  GLU B CG  1 
ATOM   2497 C  CD  . GLU B 1 70  ? -22.71019 46.59672 -68.77674 1.000 57.04112  ? 68  GLU B CD  1 
ATOM   2498 O  OE1 . GLU B 1 70  ? -22.54710 46.75524 -70.01145 1.000 60.98192  ? 68  GLU B OE1 1 
ATOM   2499 O  OE2 . GLU B 1 70  ? -21.81359 46.08494 -68.06203 1.000 53.50551  ? 68  GLU B OE2 1 
ATOM   2500 N  N   . LEU B 1 71  ? -26.46904 50.50114 -70.15078 1.000 37.96499  ? 69  LEU B N   1 
ATOM   2501 C  CA  . LEU B 1 71  ? -27.47110 51.11769 -71.00613 1.000 40.71794  ? 69  LEU B CA  1 
ATOM   2502 C  C   . LEU B 1 71  ? -26.82880 52.07984 -72.00431 1.000 41.31926  ? 69  LEU B C   1 
ATOM   2503 O  O   . LEU B 1 71  ? -27.27432 52.16523 -73.15557 1.000 41.79818  ? 69  LEU B O   1 
ATOM   2504 C  CB  . LEU B 1 71  ? -28.53292 51.82108 -70.15038 1.000 41.26525  ? 69  LEU B CB  1 
ATOM   2505 C  CG  . LEU B 1 71  ? -29.52423 50.89601 -69.42366 1.000 42.41332  ? 69  LEU B CG  1 
ATOM   2506 C  CD1 . LEU B 1 71  ? -30.46220 51.68914 -68.54136 1.000 42.58602  ? 69  LEU B CD1 1 
ATOM   2507 C  CD2 . LEU B 1 71  ? -30.32317 50.04093 -70.39058 1.000 37.54190  ? 69  LEU B CD2 1 
ATOM   2508 N  N   . ARG B 1 72  ? -25.78400 52.79782 -71.58724 1.000 40.14890  ? 70  ARG B N   1 
ATOM   2509 C  CA  . ARG B 1 72  ? -25.00027 53.59239 -72.52964 1.000 43.98633  ? 70  ARG B CA  1 
ATOM   2510 C  C   . ARG B 1 72  ? -24.45130 52.72470 -73.65457 1.000 43.02898  ? 70  ARG B C   1 
ATOM   2511 O  O   . ARG B 1 72  ? -24.53322 53.09986 -74.82882 1.000 47.37019  ? 70  ARG B O   1 
ATOM   2512 C  CB  . ARG B 1 72  ? -23.86958 54.30394 -71.80065 1.000 43.66990  ? 70  ARG B CB  1 
ATOM   2513 C  CG  . ARG B 1 72  ? -24.32892 55.55767 -71.09322 1.000 50.55781  ? 70  ARG B CG  1 
ATOM   2514 C  CD  . ARG B 1 72  ? -23.25985 56.06772 -70.14723 1.000 57.23882  ? 70  ARG B CD  1 
ATOM   2515 N  NE  . ARG B 1 72  ? -22.02354 56.40958 -70.84295 1.000 77.01244  ? 70  ARG B NE  1 
ATOM   2516 C  CZ  . ARG B 1 72  ? -20.80419 56.25836 -70.33865 1.000 76.76092  ? 70  ARG B CZ  1 
ATOM   2517 N  NH1 . ARG B 1 72  ? -20.61021 55.78059 -69.11761 1.000 63.74322  ? 70  ARG B NH1 1 
ATOM   2518 N  NH2 . ARG B 1 72  ? -19.75170 56.60678 -71.07342 1.000 79.37846  ? 70  ARG B NH2 1 
ATOM   2519 N  N   . ARG B 1 73  ? -23.93528 51.53877 -73.32393 1.000 41.87545  ? 71  ARG B N   1 
ATOM   2520 C  CA  . ARG B 1 73  ? -23.48846 50.62170 -74.36850 1.000 39.08925  ? 71  ARG B CA  1 
ATOM   2521 C  C   . ARG B 1 73  ? -24.63743 50.19047 -75.27010 1.000 46.01139  ? 71  ARG B C   1 
ATOM   2522 O  O   . ARG B 1 73  ? -24.46652 50.09156 -76.49256 1.000 52.85282  ? 71  ARG B O   1 
ATOM   2523 C  CB  . ARG B 1 73  ? -22.80675 49.40521 -73.75093 1.000 39.69666  ? 71  ARG B CB  1 
ATOM   2524 C  CG  . ARG B 1 73  ? -21.51186 49.76810 -73.03228 1.000 38.63639  ? 71  ARG B CG  1 
ATOM   2525 C  CD  . ARG B 1 73  ? -20.85201 48.54786 -72.38690 1.000 38.89185  ? 71  ARG B CD  1 
ATOM   2526 N  NE  . ARG B 1 73  ? -20.48773 47.51656 -73.35373 1.000 48.59226  ? 71  ARG B NE  1 
ATOM   2527 C  CZ  . ARG B 1 73  ? -20.07219 46.30054 -73.01589 1.000 55.92851  ? 71  ARG B CZ  1 
ATOM   2528 N  NH1 . ARG B 1 73  ? -19.97688 45.93333 -71.74892 1.000 50.46261  ? 71  ARG B NH1 1 
ATOM   2529 N  NH2 . ARG B 1 73  ? -19.75638 45.42820 -73.97132 1.000 50.78423  ? 71  ARG B NH2 1 
ATOM   2530 N  N   . ALA B 1 74  ? -25.81640 49.92475 -74.69728 1.000 44.99296  ? 72  ALA B N   1 
ATOM   2531 C  CA  . ALA B 1 74  ? -26.95035 49.54517 -75.53839 1.000 47.08611  ? 72  ALA B CA  1 
ATOM   2532 C  C   . ALA B 1 74  ? -27.25813 50.63220 -76.55762 1.000 46.87202  ? 72  ALA B C   1 
ATOM   2533 O  O   . ALA B 1 74  ? -27.57700 50.33928 -77.71347 1.000 43.89808  ? 72  ALA B O   1 
ATOM   2534 C  CB  . ALA B 1 74  ? -28.18890 49.25968 -74.68886 1.000 39.44946  ? 72  ALA B CB  1 
ATOM   2535 N  N   . ILE B 1 75  ? -27.17159 51.89533 -76.14201 1.000 44.60143  ? 73  ILE B N   1 
ATOM   2536 C  CA  . ILE B 1 75  ? -27.44054 52.99099 -77.06101 1.000 49.91450  ? 73  ILE B CA  1 
ATOM   2537 C  C   . ILE B 1 75  ? -26.46384 52.94836 -78.22895 1.000 48.89623  ? 73  ILE B C   1 
ATOM   2538 O  O   . ILE B 1 75  ? -26.86286 53.07552 -79.39250 1.000 48.01787  ? 73  ILE B O   1 
ATOM   2539 C  CB  . ILE B 1 75  ? -27.38403 54.33632 -76.31561 1.000 49.98091  ? 73  ILE B CB  1 
ATOM   2540 C  CG1 . ILE B 1 75  ? -28.51269 54.43380 -75.30559 1.000 40.83657  ? 73  ILE B CG1 1 
ATOM   2541 C  CG2 . ILE B 1 75  ? -27.49843 55.48916 -77.28682 1.000 42.97741  ? 73  ILE B CG2 1 
ATOM   2542 C  CD1 . ILE B 1 75  ? -28.35093 55.64942 -74.36019 1.000 45.50476  ? 73  ILE B CD1 1 
ATOM   2543 N  N   . GLY B 1 76  ? -25.17726 52.72540 -77.93995 1.000 46.93825  ? 74  GLY B N   1 
ATOM   2544 C  CA  . GLY B 1 76  ? -24.19529 52.60241 -79.00672 1.000 41.83746  ? 74  GLY B CA  1 
ATOM   2545 C  C   . GLY B 1 76  ? -24.53264 51.48937 -79.97884 1.000 49.91416  ? 74  GLY B C   1 
ATOM   2546 O  O   . GLY B 1 76  ? -24.57241 51.69486 -81.19293 1.000 58.59679  ? 74  GLY B O   1 
ATOM   2547 N  N   . HIS B 1 77  ? -24.79804 50.29615 -79.45555 1.000 48.54748  ? 75  HIS B N   1 
ATOM   2548 C  CA  . HIS B 1 77  ? -25.16270 49.18196 -80.31862 1.000 50.28363  ? 75  HIS B CA  1 
ATOM   2549 C  C   . HIS B 1 77  ? -26.40318 49.49004 -81.14965 1.000 50.48872  ? 75  HIS B C   1 
ATOM   2550 O  O   . HIS B 1 77  ? -26.45106 49.17533 -82.34444 1.000 52.74226  ? 75  HIS B O   1 
ATOM   2551 C  CB  . HIS B 1 77  ? -25.38265 47.93423 -79.47543 1.000 46.37614  ? 75  HIS B CB  1 
ATOM   2552 C  CG  . HIS B 1 77  ? -24.14150 47.44657 -78.81428 1.000 51.70129  ? 75  HIS B CG  1 
ATOM   2553 N  ND1 . HIS B 1 77  ? -22.91297 47.48219 -79.43680 1.000 55.89081  ? 75  HIS B ND1 1 
ATOM   2554 C  CD2 . HIS B 1 77  ? -23.93098 46.91850 -77.58580 1.000 46.61249  ? 75  HIS B CD2 1 
ATOM   2555 C  CE1 . HIS B 1 77  ? -21.99805 46.99151 -78.62106 1.000 60.34324  ? 75  HIS B CE1 1 
ATOM   2556 N  NE2 . HIS B 1 77  ? -22.58989 46.64832 -77.48963 1.000 57.48187  ? 75  HIS B NE2 1 
ATOM   2557 N  N   . LEU B 1 78  ? -27.42705 50.08179 -80.53406 1.000 48.12141  ? 76  LEU B N   1 
ATOM   2558 C  CA  . LEU B 1 78  ? -28.65065 50.36445 -81.27641 1.000 47.87677  ? 76  LEU B CA  1 
ATOM   2559 C  C   . LEU B 1 78  ? -28.40155 51.39424 -82.37322 1.000 51.91398  ? 76  LEU B C   1 
ATOM   2560 O  O   . LEU B 1 78  ? -28.91728 51.25508 -83.49001 1.000 47.51059  ? 76  LEU B O   1 
ATOM   2561 C  CB  . LEU B 1 78  ? -29.74351 50.84447 -80.32351 1.000 39.68484  ? 76  LEU B CB  1 
ATOM   2562 C  CG  . LEU B 1 78  ? -30.36717 49.74733 -79.45628 1.000 41.85042  ? 76  LEU B CG  1 
ATOM   2563 C  CD1 . LEU B 1 78  ? -31.31997 50.34730 -78.43475 1.000 37.74126  ? 76  LEU B CD1 1 
ATOM   2564 C  CD2 . LEU B 1 78  ? -31.06717 48.70770 -80.31378 1.000 40.42564  ? 76  LEU B CD2 1 
ATOM   2565 N  N   . ASP B 1 79  ? -27.61133 52.43280 -82.07158 1.000 49.44567  ? 77  ASP B N   1 
ATOM   2566 C  CA  . ASP B 1 79  ? -27.31755 53.47190 -83.05018 1.000 50.82854  ? 77  ASP B CA  1 
ATOM   2567 C  C   . ASP B 1 79  ? -26.50713 52.94381 -84.23597 1.000 55.01084  ? 77  ASP B C   1 
ATOM   2568 O  O   . ASP B 1 79  ? -26.52778 53.56830 -85.30172 1.000 54.94966  ? 77  ASP B O   1 
ATOM   2569 C  CB  . ASP B 1 79  ? -26.58719 54.63953 -82.37100 1.000 44.67016  ? 77  ASP B CB  1 
ATOM   2570 C  CG  . ASP B 1 79  ? -27.52989 55.52186 -81.54774 1.000 50.77055  ? 77  ASP B CG  1 
ATOM   2571 O  OD1 . ASP B 1 79  ? -28.76342 55.40498 -81.72634 1.000 50.12318  ? 77  ASP B OD1 1 
ATOM   2572 O  OD2 . ASP B 1 79  ? -27.05104 56.34640 -80.73167 1.000 52.67165  ? 77  ASP B OD2 1 
ATOM   2573 N  N   . GLU B 1 80  ? -25.82973 51.79741 -84.08791 1.000 51.37247  ? 78  GLU B N   1 
ATOM   2574 C  CA  . GLU B 1 80  ? -25.02785 51.19953 -85.15274 1.000 50.93758  ? 78  GLU B CA  1 
ATOM   2575 C  C   . GLU B 1 80  ? -25.63104 49.90000 -85.66613 1.000 53.35704  ? 78  GLU B C   1 
ATOM   2576 O  O   . GLU B 1 80  ? -24.92783 49.10796 -86.30321 1.000 56.34050  ? 78  GLU B O   1 
ATOM   2577 C  CB  . GLU B 1 80  ? -23.59170 50.93695 -84.68265 1.000 53.12379  ? 78  GLU B CB  1 
ATOM   2578 C  CG  . GLU B 1 80  ? -22.77053 52.18648 -84.33025 1.000 64.22524  ? 78  GLU B CG  1 
ATOM   2579 C  CD  . GLU B 1 80  ? -22.70584 53.23193 -85.45491 1.000 82.84190  ? 78  GLU B CD  1 
ATOM   2580 O  OE1 . GLU B 1 80  ? -22.79797 52.87111 -86.65794 1.000 84.07222  ? 78  GLU B OE1 1 
ATOM   2581 O  OE2 . GLU B 1 80  ? -22.59127 54.43565 -85.12366 1.000 86.75382  ? 78  GLU B OE2 1 
ATOM   2582 N  N   . ASP B 1 81  ? -26.90468 49.64642 -85.36371 1.000 52.00234  ? 79  ASP B N   1 
ATOM   2583 C  CA  . ASP B 1 81  ? -27.63635 48.46996 -85.82855 1.000 51.58524  ? 79  ASP B CA  1 
ATOM   2584 C  C   . ASP B 1 81  ? -27.04694 47.15442 -85.32605 1.000 54.51155  ? 79  ASP B C   1 
ATOM   2585 O  O   . ASP B 1 81  ? -27.25040 46.10204 -85.94282 1.000 47.92807  ? 79  ASP B O   1 
ATOM   2586 C  CB  . ASP B 1 81  ? -27.72501 48.44971 -87.35404 1.000 47.43797  ? 79  ASP B CB  1 
ATOM   2587 C  CG  . ASP B 1 81  ? -28.62664 49.55234 -87.89460 1.000 62.94855  ? 79  ASP B CG  1 
ATOM   2588 O  OD1 . ASP B 1 81  ? -29.42786 50.11419 -87.10360 1.000 58.25256  ? 79  ASP B OD1 1 
ATOM   2589 O  OD2 . ASP B 1 81  ? -28.54013 49.85556 -89.10902 1.000 73.40324  ? 79  ASP B OD2 1 
ATOM   2590 N  N   . ARG B 1 82  ? -26.31569 47.17773 -84.21537 1.000 52.82229  ? 80  ARG B N   1 
ATOM   2591 C  CA  . ARG B 1 82  ? -25.74325 45.95494 -83.65768 1.000 52.45218  ? 80  ARG B CA  1 
ATOM   2592 C  C   . ARG B 1 82  ? -26.72944 45.38113 -82.63603 1.000 52.03880  ? 80  ARG B C   1 
ATOM   2593 O  O   . ARG B 1 82  ? -26.52788 45.41881 -81.41898 1.000 56.67849  ? 80  ARG B O   1 
ATOM   2594 C  CB  . ARG B 1 82  ? -24.36802 46.24363 -83.06464 1.000 59.71860  ? 80  ARG B CB  1 
ATOM   2595 C  CG  . ARG B 1 82  ? -23.42337 46.94866 -84.05236 1.000 55.94116  ? 80  ARG B CG  1 
ATOM   2596 C  CD  . ARG B 1 82  ? -21.97160 47.00047 -83.56904 1.000 51.24246  ? 80  ARG B CD  1 
ATOM   2597 N  NE  . ARG B 1 82  ? -21.82931 47.80192 -82.35678 1.000 65.51541  ? 80  ARG B NE  1 
ATOM   2598 C  CZ  . ARG B 1 82  ? -21.32145 49.03128 -82.29592 1.000 71.15319  ? 80  ARG B CZ  1 
ATOM   2599 N  NH1 . ARG B 1 82  ? -20.87693 49.65656 -83.37932 1.000 67.03367  ? 80  ARG B NH1 1 
ATOM   2600 N  NH2 . ARG B 1 82  ? -21.25999 49.65116 -81.11389 1.000 56.81200  ? 80  ARG B NH2 1 
ATOM   2601 N  N   . TYR B 1 83  ? -27.82877 44.84369 -83.17831 1.000 48.60504  ? 81  TYR B N   1 
ATOM   2602 C  CA  . TYR B 1 83  ? -28.98395 44.46271 -82.37104 1.000 42.71317  ? 81  TYR B CA  1 
ATOM   2603 C  C   . TYR B 1 83  ? -28.66862 43.28922 -81.44186 1.000 45.76692  ? 81  TYR B C   1 
ATOM   2604 O  O   . TYR B 1 83  ? -29.06318 43.29691 -80.26713 1.000 45.30907  ? 81  TYR B O   1 
ATOM   2605 C  CB  . TYR B 1 83  ? -30.17129 44.12521 -83.27781 1.000 43.43758  ? 81  TYR B CB  1 
ATOM   2606 C  CG  . TYR B 1 83  ? -30.58975 45.19998 -84.29315 1.000 52.06162  ? 81  TYR B CG  1 
ATOM   2607 C  CD1 . TYR B 1 83  ? -30.46437 46.56575 -84.01524 1.000 53.87936  ? 81  TYR B CD1 1 
ATOM   2608 C  CD2 . TYR B 1 83  ? -31.12296 44.83702 -85.54108 1.000 53.97979  ? 81  TYR B CD2 1 
ATOM   2609 C  CE1 . TYR B 1 83  ? -30.85869 47.54936 -84.96101 1.000 48.95886  ? 81  TYR B CE1 1 
ATOM   2610 C  CE2 . TYR B 1 83  ? -31.51834 45.80528 -86.48730 1.000 47.60599  ? 81  TYR B CE2 1 
ATOM   2611 C  CZ  . TYR B 1 83  ? -31.38375 47.15726 -86.19389 1.000 60.10790  ? 81  TYR B CZ  1 
ATOM   2612 O  OH  . TYR B 1 83  ? -31.78128 48.11014 -87.14028 1.000 64.83439  ? 81  TYR B OH  1 
ATOM   2613 N  N   . HIS B 1 84  ? -27.97223 42.26884 -81.93737 1.000 41.61679  ? 82  HIS B N   1 
ATOM   2614 C  CA  . HIS B 1 84  ? -27.60524 41.15332 -81.06722 1.000 45.30640  ? 82  HIS B CA  1 
ATOM   2615 C  C   . HIS B 1 84  ? -26.75229 41.61451 -79.89684 1.000 47.90447  ? 82  HIS B C   1 
ATOM   2616 O  O   . HIS B 1 84  ? -26.85126 41.06636 -78.79798 1.000 49.97567  ? 82  HIS B O   1 
ATOM   2617 C  CB  . HIS B 1 84  ? -26.84299 40.08358 -81.83997 1.000 45.26083  ? 82  HIS B CB  1 
ATOM   2618 C  CG  . HIS B 1 84  ? -27.63971 39.43293 -82.91886 1.000 50.71164  ? 82  HIS B CG  1 
ATOM   2619 N  ND1 . HIS B 1 84  ? -27.70735 39.93951 -84.20058 1.000 54.65664  ? 82  HIS B ND1 1 
ATOM   2620 C  CD2 . HIS B 1 84  ? -28.39383 38.30859 -82.91729 1.000 55.09347  ? 82  HIS B CD2 1 
ATOM   2621 C  CE1 . HIS B 1 84  ? -28.47393 39.15753 -84.94131 1.000 52.48340  ? 82  HIS B CE1 1 
ATOM   2622 N  NE2 . HIS B 1 84  ? -28.90337 38.15974 -84.18714 1.000 55.84413  ? 82  HIS B NE2 1 
ATOM   2623 N  N   . GLN B 1 85  ? -25.90849 42.61276 -80.09826 1.000 47.32924  ? 83  GLN B N   1 
ATOM   2624 C  CA  . GLN B 1 85  ? -25.12432 43.06765 -78.96455 1.000 49.70734  ? 83  GLN B CA  1 
ATOM   2625 C  C   . GLN B 1 85  ? -25.94317 43.91617 -77.99985 1.000 44.16911  ? 83  GLN B C   1 
ATOM   2626 O  O   . GLN B 1 85  ? -25.68068 43.88570 -76.79680 1.000 50.27112  ? 83  GLN B O   1 
ATOM   2627 C  CB  . GLN B 1 85  ? -23.88968 43.80587 -79.46659 1.000 51.90229  ? 83  GLN B CB  1 
ATOM   2628 C  CG  . GLN B 1 85  ? -22.96822 42.85381 -80.20650 1.000 58.15701  ? 83  GLN B CG  1 
ATOM   2629 C  CD  . GLN B 1 85  ? -22.10721 43.54081 -81.25097 1.000 67.11602  ? 83  GLN B CD  1 
ATOM   2630 O  OE1 . GLN B 1 85  ? -22.36453 43.43136 -82.45604 1.000 69.88657  ? 83  GLN B OE1 1 
ATOM   2631 N  NE2 . GLN B 1 85  ? -21.06769 44.24096 -80.79626 1.000 64.86751  ? 83  GLN B NE2 1 
ATOM   2632 N  N   . ALA B 1 86  ? -26.93217 44.66663 -78.49137 1.000 44.03697  ? 84  ALA B N   1 
ATOM   2633 C  CA  . ALA B 1 86  ? -27.81724 45.39732 -77.58635 1.000 46.68534  ? 84  ALA B CA  1 
ATOM   2634 C  C   . ALA B 1 86  ? -28.56400 44.44674 -76.65376 1.000 44.40956  ? 84  ALA B C   1 
ATOM   2635 O  O   . ALA B 1 86  ? -28.69541 44.72365 -75.45760 1.000 49.62621  ? 84  ALA B O   1 
ATOM   2636 C  CB  . ALA B 1 86  ? -28.81437 46.24763 -78.38132 1.000 43.62591  ? 84  ALA B CB  1 
ATOM   2637 N  N   . VAL B 1 87  ? -29.04647 43.31859 -77.18508 1.000 40.33587  ? 85  VAL B N   1 
ATOM   2638 C  CA  . VAL B 1 87  ? -29.77845 42.33975 -76.38362 1.000 44.97470  ? 85  VAL B CA  1 
ATOM   2639 C  C   . VAL B 1 87  ? -28.99679 41.99167 -75.13020 1.000 44.70562  ? 85  VAL B C   1 
ATOM   2640 O  O   . VAL B 1 87  ? -29.53263 42.00774 -74.01575 1.000 42.99423  ? 85  VAL B O   1 
ATOM   2641 C  CB  . VAL B 1 87  ? -30.07916 41.07417 -77.21197 1.000 42.54291  ? 85  VAL B CB  1 
ATOM   2642 C  CG1 . VAL B 1 87  ? -30.82723 40.06448 -76.37977 1.000 39.37784  ? 85  VAL B CG1 1 
ATOM   2643 C  CG2 . VAL B 1 87  ? -30.91275 41.42378 -78.41040 1.000 47.19328  ? 85  VAL B CG2 1 
ATOM   2644 N  N   . ARG B 1 88  ? -27.71109 41.68245 -75.29611 1.000 45.95633  ? 86  ARG B N   1 
ATOM   2645 C  CA  . ARG B 1 88  ? -26.91852 41.22413 -74.16484 1.000 42.41514  ? 86  ARG B CA  1 
ATOM   2646 C  C   . ARG B 1 88  ? -26.79224 42.31116 -73.11818 1.000 44.95446  ? 86  ARG B C   1 
ATOM   2647 O  O   . ARG B 1 88  ? -26.79481 42.02649 -71.91266 1.000 47.13009  ? 86  ARG B O   1 
ATOM   2648 C  CB  . ARG B 1 88  ? -25.54338 40.77735 -74.63583 1.000 45.34209  ? 86  ARG B CB  1 
ATOM   2649 C  CG  . ARG B 1 88  ? -25.57208 39.53365 -75.48347 1.000 41.72038  ? 86  ARG B CG  1 
ATOM   2650 C  CD  . ARG B 1 88  ? -24.15810 39.02184 -75.64397 1.000 48.97600  ? 86  ARG B CD  1 
ATOM   2651 N  NE  . ARG B 1 88  ? -24.09349 38.00230 -76.67513 1.000 49.16074  ? 86  ARG B NE  1 
ATOM   2652 C  CZ  . ARG B 1 88  ? -23.86004 38.26220 -77.95133 1.000 52.01525  ? 86  ARG B CZ  1 
ATOM   2653 N  NH1 . ARG B 1 88  ? -23.65889 39.50126 -78.37071 1.000 48.53328  ? 86  ARG B NH1 1 
ATOM   2654 N  NH2 . ARG B 1 88  ? -23.82424 37.25407 -78.82383 1.000 41.44404  ? 86  ARG B NH2 1 
ATOM   2655 N  N   . MET B 1 89  ? -26.69783 43.56503 -73.56137 1.000 37.24200  ? 87  MET B N   1 
ATOM   2656 C  CA  . MET B 1 89  ? -26.60497 44.68144 -72.62664 1.000 37.91132  ? 87  MET B CA  1 
ATOM   2657 C  C   . MET B 1 89  ? -27.87037 44.80677 -71.78869 1.000 49.20942  ? 87  MET B C   1 
ATOM   2658 O  O   . MET B 1 89  ? -27.80038 45.06535 -70.57583 1.000 44.46220  ? 87  MET B O   1 
ATOM   2659 C  CB  . MET B 1 89  ? -26.32834 45.97292 -73.40068 1.000 43.49353  ? 87  MET B CB  1 
ATOM   2660 C  CG  . MET B 1 89  ? -25.00379 45.93541 -74.14608 1.000 44.26828  ? 87  MET B CG  1 
ATOM   2661 S  SD  . MET B 1 89  ? -23.65016 45.59349 -73.00345 1.000 62.73423  ? 87  MET B SD  1 
ATOM   2662 C  CE  . MET B 1 89  ? -23.17263 43.95382 -73.55752 1.000 49.36468  ? 87  MET B CE  1 
ATOM   2663 N  N   . PHE B 1 90  ? -29.04137 44.61595 -72.41634 1.000 40.09297  ? 88  PHE B N   1 
ATOM   2664 C  CA  . PHE B 1 90  ? -30.28919 44.73235 -71.67389 1.000 40.24570  ? 88  PHE B CA  1 
ATOM   2665 C  C   . PHE B 1 90  ? -30.46164 43.56376 -70.71805 1.000 41.79618  ? 88  PHE B C   1 
ATOM   2666 O  O   . PHE B 1 90  ? -30.93631 43.75066 -69.59261 1.000 41.17782  ? 88  PHE B O   1 
ATOM   2667 C  CB  . PHE B 1 90  ? -31.48247 44.83445 -72.62978 1.000 41.21687  ? 88  PHE B CB  1 
ATOM   2668 C  CG  . PHE B 1 90  ? -31.59756 46.17669 -73.29598 1.000 45.86683  ? 88  PHE B CG  1 
ATOM   2669 C  CD1 . PHE B 1 90  ? -31.78742 47.32919 -72.53613 1.000 39.07342  ? 88  PHE B CD1 1 
ATOM   2670 C  CD2 . PHE B 1 90  ? -31.50224 46.29441 -74.68391 1.000 40.44235  ? 88  PHE B CD2 1 
ATOM   2671 C  CE1 . PHE B 1 90  ? -31.88928 48.58174 -73.15013 1.000 40.13643  ? 88  PHE B CE1 1 
ATOM   2672 C  CE2 . PHE B 1 90  ? -31.59693 47.54418 -75.30026 1.000 42.18935  ? 88  PHE B CE2 1 
ATOM   2673 C  CZ  . PHE B 1 90  ? -31.78953 48.68979 -74.52974 1.000 35.56856  ? 88  PHE B CZ  1 
ATOM   2674 N  N   . ASP B 1 91  ? -30.06932 42.35745 -71.14704 1.000 41.12826  ? 89  ASP B N   1 
ATOM   2675 C  CA  . ASP B 1 91  ? -30.13990 41.17804 -70.28347 1.000 37.81994  ? 89  ASP B CA  1 
ATOM   2676 C  C   . ASP B 1 91  ? -29.25158 41.34457 -69.05355 1.000 43.05063  ? 89  ASP B C   1 
ATOM   2677 O  O   . ASP B 1 91  ? -29.64806 40.99217 -67.93496 1.000 42.39816  ? 89  ASP B O   1 
ATOM   2678 C  CB  . ASP B 1 91  ? -29.71044 39.94793 -71.07071 1.000 42.50112  ? 89  ASP B CB  1 
ATOM   2679 C  CG  . ASP B 1 91  ? -30.82189 39.39246 -71.96343 1.000 61.99236  ? 89  ASP B CG  1 
ATOM   2680 O  OD1 . ASP B 1 91  ? -31.97505 39.88076 -71.88366 1.000 58.16549  ? 89  ASP B OD1 1 
ATOM   2681 O  OD2 . ASP B 1 91  ? -30.51659 38.50120 -72.80031 1.000 65.91028  ? 89  ASP B OD2 1 
ATOM   2682 N  N   . ARG B 1 92  ? -28.04056 41.87820 -69.24985 1.000 41.31975  ? 90  ARG B N   1 
ATOM   2683 C  CA  . ARG B 1 92  ? -27.12924 42.11803 -68.13834 1.000 42.39661  ? 90  ARG B CA  1 
ATOM   2684 C  C   . ARG B 1 92  ? -27.69979 43.16344 -67.18422 1.000 41.83048  ? 90  ARG B C   1 
ATOM   2685 O  O   . ARG B 1 92  ? -27.64786 42.99462 -65.96002 1.000 37.70368  ? 90  ARG B O   1 
ATOM   2686 C  CB  . ARG B 1 92  ? -25.76558 42.55438 -68.68089 1.000 40.96399  ? 90  ARG B CB  1 
ATOM   2687 C  CG  . ARG B 1 92  ? -24.69402 42.74801 -67.62193 1.000 47.45358  ? 90  ARG B CG  1 
ATOM   2688 C  CD  . ARG B 1 92  ? -23.39159 43.27243 -68.23708 1.000 49.60035  ? 90  ARG B CD  1 
ATOM   2689 N  NE  . ARG B 1 92  ? -22.85646 42.37578 -69.26144 1.000 53.10135  ? 90  ARG B NE  1 
ATOM   2690 C  CZ  . ARG B 1 92  ? -21.64317 42.50227 -69.78340 1.000 54.43832  ? 90  ARG B CZ  1 
ATOM   2691 N  NH1 . ARG B 1 92  ? -20.82490 43.45811 -69.38329 1.000 49.16919  ? 90  ARG B NH1 1 
ATOM   2692 N  NH2 . ARG B 1 92  ? -21.23807 41.64431 -70.72273 1.000 47.95008  ? 90  ARG B NH2 1 
ATOM   2693 N  N   . ALA B 1 93  ? -28.26945 44.24057 -67.73506 1.000 39.64440  ? 91  ALA B N   1 
ATOM   2694 C  CA  . ALA B 1 93  ? -28.88746 45.27006 -66.90894 1.000 37.72863  ? 91  ALA B CA  1 
ATOM   2695 C  C   . ALA B 1 93  ? -30.02191 44.69472 -66.06065 1.000 39.12314  ? 91  ALA B C   1 
ATOM   2696 O  O   . ALA B 1 93  ? -30.18332 45.06429 -64.89192 1.000 35.42581  ? 91  ALA B O   1 
ATOM   2697 C  CB  . ALA B 1 93  ? -29.40139 46.39649 -67.80495 1.000 38.11026  ? 91  ALA B CB  1 
ATOM   2698 N  N   . THR B 1 94  ? -30.82124 43.79430 -66.63621 1.000 33.17045  ? 92  THR B N   1 
ATOM   2699 C  CA  . THR B 1 94  ? -31.88844 43.15984 -65.87531 1.000 37.68836  ? 92  THR B CA  1 
ATOM   2700 C  C   . THR B 1 94  ? -31.32000 42.35718 -64.72048 1.000 37.74942  ? 92  THR B C   1 
ATOM   2701 O  O   . THR B 1 94  ? -31.82224 42.43781 -63.59592 1.000 44.80828  ? 92  THR B O   1 
ATOM   2702 C  CB  . THR B 1 94  ? -32.73001 42.26205 -66.78511 1.000 37.80638  ? 92  THR B CB  1 
ATOM   2703 O  OG1 . THR B 1 94  ? -33.37495 43.07386 -67.76061 1.000 42.55280  ? 92  THR B OG1 1 
ATOM   2704 C  CG2 . THR B 1 94  ? -33.81311 41.55322 -65.99663 1.000 29.18024  ? 92  THR B CG2 1 
ATOM   2705 N  N   . GLY B 1 95  ? -30.27105 41.56566 -64.98071 1.000 41.03909  ? 93  GLY B N   1 
ATOM   2706 C  CA  . GLY B 1 95  ? -29.65767 40.79746 -63.90922 1.000 31.26434  ? 93  GLY B CA  1 
ATOM   2707 C  C   . GLY B 1 95  ? -29.18674 41.68730 -62.77765 1.000 38.70689  ? 93  GLY B C   1 
ATOM   2708 O  O   . GLY B 1 95  ? -29.33369 41.34631 -61.60344 1.000 36.24156  ? 93  GLY B O   1 
ATOM   2709 N  N   . LEU B 1 96  ? -28.63796 42.85477 -63.11552 1.000 35.90560  ? 94  LEU B N   1 
ATOM   2710 C  CA  . LEU B 1 96  ? -28.16648 43.76934 -62.08174 1.000 36.39571  ? 94  LEU B CA  1 
ATOM   2711 C  C   . LEU B 1 96  ? -29.32748 44.38233 -61.31454 1.000 37.97276  ? 94  LEU B C   1 
ATOM   2712 O  O   . LEU B 1 96  ? -29.24364 44.56946 -60.09678 1.000 39.57324  ? 94  LEU B O   1 
ATOM   2713 C  CB  . LEU B 1 96  ? -27.31852 44.86956 -62.70524 1.000 37.04325  ? 94  LEU B CB  1 
ATOM   2714 C  CG  . LEU B 1 96  ? -25.95430 44.44929 -63.23505 1.000 40.38110  ? 94  LEU B CG  1 
ATOM   2715 C  CD1 . LEU B 1 96  ? -25.55045 45.39933 -64.38053 1.000 37.69238  ? 94  LEU B CD1 1 
ATOM   2716 C  CD2 . LEU B 1 96  ? -24.92443 44.41678 -62.07698 1.000 31.24910  ? 94  LEU B CD2 1 
ATOM   2717 N  N   . SER B 1 97  ? -30.40844 44.72106 -62.01990 1.000 37.05211  ? 95  SER B N   1 
ATOM   2718 C  CA  . SER B 1 97  ? -31.60883 45.23430 -61.37652 1.000 39.29190  ? 95  SER B CA  1 
ATOM   2719 C  C   . SER B 1 97  ? -32.17259 44.24129 -60.35905 1.000 40.89854  ? 95  SER B C   1 
ATOM   2720 O  O   . SER B 1 97  ? -32.62836 44.63344 -59.26991 1.000 36.03469  ? 95  SER B O   1 
ATOM   2721 C  CB  . SER B 1 97  ? -32.64773 45.55543 -62.44922 1.000 42.25896  ? 95  SER B CB  1 
ATOM   2722 O  OG  . SER B 1 97  ? -33.84336 46.05366 -61.87152 1.000 48.64535  ? 95  SER B OG  1 
ATOM   2723 N  N   . GLU B 1 98  ? -32.13483 42.95189 -60.69237 1.000 32.12463  ? 96  GLU B N   1 
ATOM   2724 C  CA  . GLU B 1 98  ? -32.60354 41.93210 -59.76769 1.000 34.78054  ? 96  GLU B CA  1 
ATOM   2725 C  C   . GLU B 1 98  ? -31.76813 41.89064 -58.49326 1.000 44.99849  ? 96  GLU B C   1 
ATOM   2726 O  O   . GLU B 1 98  ? -32.26208 41.46740 -57.43881 1.000 44.55520  ? 96  GLU B O   1 
ATOM   2727 C  CB  . GLU B 1 98  ? -32.60137 40.57667 -60.46565 1.000 37.55149  ? 96  GLU B CB  1 
ATOM   2728 C  CG  . GLU B 1 98  ? -33.76363 40.37804 -61.46377 1.000 50.58774  ? 96  GLU B CG  1 
ATOM   2729 C  CD  . GLU B 1 98  ? -35.15777 40.69592 -60.87460 1.000 60.25662  ? 96  GLU B CD  1 
ATOM   2730 O  OE1 . GLU B 1 98  ? -35.73842 41.74633 -61.22558 1.000 54.89197  ? 96  GLU B OE1 1 
ATOM   2731 O  OE2 . GLU B 1 98  ? -35.66757 39.89392 -60.04504 1.000 62.70269  ? 96  GLU B OE2 1 
ATOM   2732 N  N   . VAL B 1 99  ? -30.50652 42.31643 -58.55634 1.000 43.03764  ? 97  VAL B N   1 
ATOM   2733 C  CA  . VAL B 1 99  ? -29.73232 42.41796 -57.32713 1.000 39.26018  ? 97  VAL B CA  1 
ATOM   2734 C  C   . VAL B 1 99  ? -30.30423 43.51092 -56.43760 1.000 38.58341  ? 97  VAL B C   1 
ATOM   2735 O  O   . VAL B 1 99  ? -30.43039 43.32885 -55.22363 1.000 39.15028  ? 97  VAL B O   1 
ATOM   2736 C  CB  . VAL B 1 99  ? -28.24696 42.65322 -57.65102 1.000 42.33551  ? 97  VAL B CB  1 
ATOM   2737 C  CG1 . VAL B 1 99  ? -27.46862 43.01485 -56.38539 1.000 36.51623  ? 97  VAL B CG1 1 
ATOM   2738 C  CG2 . VAL B 1 99  ? -27.67377 41.41956 -58.29827 1.000 39.89689  ? 97  VAL B CG2 1 
ATOM   2739 N  N   . THR B 1 100 ? -30.66604 44.66308 -57.02029 1.000 33.79310  ? 98  THR B N   1 
ATOM   2740 C  CA  . THR B 1 100 ? -31.25689 45.72373 -56.20616 1.000 36.80282  ? 98  THR B CA  1 
ATOM   2741 C  C   . THR B 1 100 ? -32.56559 45.27605 -55.57310 1.000 38.34937  ? 98  THR B C   1 
ATOM   2742 O  O   . THR B 1 100 ? -32.90864 45.73786 -54.48181 1.000 42.18956  ? 98  THR B O   1 
ATOM   2743 C  CB  . THR B 1 100 ? -31.48994 47.00389 -57.02124 1.000 40.28036  ? 98  THR B CB  1 
ATOM   2744 O  OG1 . THR B 1 100 ? -32.58749 46.82712 -57.93393 1.000 37.14316  ? 98  THR B OG1 1 
ATOM   2745 C  CG2 . THR B 1 100 ? -30.23334 47.39199 -57.78598 1.000 34.22331  ? 98  THR B CG2 1 
ATOM   2746 N  N   . VAL B 1 101 ? -33.29995 44.37826 -56.23148 1.000 35.85570  ? 99  VAL B N   1 
ATOM   2747 C  CA  . VAL B 1 101 ? -34.54089 43.86990 -55.65757 1.000 39.96450  ? 99  VAL B CA  1 
ATOM   2748 C  C   . VAL B 1 101 ? -34.23865 43.00913 -54.43458 1.000 39.91738  ? 99  VAL B C   1 
ATOM   2749 O  O   . VAL B 1 101 ? -34.84516 43.18131 -53.36928 1.000 43.70677  ? 99  VAL B O   1 
ATOM   2750 C  CB  . VAL B 1 101 ? -35.35520 43.10463 -56.72837 1.000 38.74668  ? 99  VAL B CB  1 
ATOM   2751 C  CG1 . VAL B 1 101 ? -36.61817 42.49009 -56.14319 1.000 35.12935  ? 99  VAL B CG1 1 
ATOM   2752 C  CG2 . VAL B 1 101 ? -35.74344 44.03795 -57.82986 1.000 36.36200  ? 99  VAL B CG2 1 
ATOM   2753 N  N   A GLN B 1 102 ? -33.30561 42.05853 -54.58316 0.540 39.69691  ? 100 GLN B N   1 
ATOM   2754 N  N   B GLN B 1 102 ? -33.28345 42.09201 -54.55156 0.460 39.78535  ? 100 GLN B N   1 
ATOM   2755 C  CA  A GLN B 1 102 ? -32.80928 41.26940 -53.45669 0.540 39.86435  ? 100 GLN B CA  1 
ATOM   2756 C  CA  B GLN B 1 102 ? -32.94332 41.27678 -53.39583 0.460 39.90652  ? 100 GLN B CA  1 
ATOM   2757 C  C   A GLN B 1 102 ? -32.41685 42.16723 -52.29609 0.540 40.72840  ? 100 GLN B C   1 
ATOM   2758 C  C   B GLN B 1 102 ? -32.30472 42.09707 -52.27917 0.460 40.73174  ? 100 GLN B C   1 
ATOM   2759 O  O   A GLN B 1 102 ? -32.76634 41.90834 -51.13797 0.540 42.97771  ? 100 GLN B O   1 
ATOM   2760 O  O   B GLN B 1 102 ? -32.40219 41.70641 -51.11012 0.460 43.17864  ? 100 GLN B O   1 
ATOM   2761 C  CB  A GLN B 1 102 ? -31.60139 40.43289 -53.89732 0.540 38.99400  ? 100 GLN B CB  1 
ATOM   2762 C  CB  B GLN B 1 102 ? -32.04165 40.12230 -53.82952 0.460 40.59029  ? 100 GLN B CB  1 
ATOM   2763 C  CG  A GLN B 1 102 ? -31.84423 38.92651 -54.00581 0.540 46.01870  ? 100 GLN B CG  1 
ATOM   2764 C  CG  B GLN B 1 102 ? -32.79112 39.02507 -54.62882 0.460 42.02324  ? 100 GLN B CG  1 
ATOM   2765 C  CD  A GLN B 1 102 ? -30.55886 38.10428 -53.84758 0.540 45.23526  ? 100 GLN B CD  1 
ATOM   2766 C  CD  B GLN B 1 102 ? -34.24097 38.82905 -54.17825 0.460 45.69975  ? 100 GLN B CD  1 
ATOM   2767 O  OE1 A GLN B 1 102 ? -30.50469 37.11847 -53.10397 0.540 37.24933  ? 100 GLN B OE1 1 
ATOM   2768 O  OE1 B GLN B 1 102 ? -35.18487 39.00542 -54.96029 0.460 39.14253  ? 100 GLN B OE1 1 
ATOM   2769 N  NE2 A GLN B 1 102 ? -29.52307 38.51761 -54.54801 0.540 42.35267  ? 100 GLN B NE2 1 
ATOM   2770 N  NE2 B GLN B 1 102 ? -34.42057 38.45799 -52.90584 0.460 45.43103  ? 100 GLN B NE2 1 
ATOM   2771 N  N   . ALA B 1 103 ? -31.69356 43.24081 -52.59977 1.000 35.27096  ? 101 ALA B N   1 
ATOM   2772 C  CA  . ALA B 1 103 ? -31.15671 44.10410 -51.55526 1.000 40.08060  ? 101 ALA B CA  1 
ATOM   2773 C  C   . ALA B 1 103 ? -32.26395 44.84730 -50.79691 1.000 43.85747  ? 101 ALA B C   1 
ATOM   2774 O  O   . ALA B 1 103 ? -32.16505 45.02432 -49.58284 1.000 43.13077  ? 101 ALA B O   1 
ATOM   2775 C  CB  . ALA B 1 103 ? -30.14439 45.09106 -52.16050 1.000 31.06721  ? 101 ALA B CB  1 
ATOM   2776 N  N   . VAL B 1 104 ? -33.31350 45.31953 -51.47694 1.000 40.45169  ? 102 VAL B N   1 
ATOM   2777 C  CA  . VAL B 1 104 ? -34.34328 46.02185 -50.71244 1.000 35.14177  ? 102 VAL B CA  1 
ATOM   2778 C  C   . VAL B 1 104 ? -35.20847 45.01943 -49.95464 1.000 38.12097  ? 102 VAL B C   1 
ATOM   2779 O  O   . VAL B 1 104 ? -35.70873 45.31881 -48.86353 1.000 43.80843  ? 102 VAL B O   1 
ATOM   2780 C  CB  . VAL B 1 104 ? -35.18781 46.96029 -51.60723 1.000 39.25327  ? 102 VAL B CB  1 
ATOM   2781 C  CG1 . VAL B 1 104 ? -36.07085 46.19966 -52.59197 1.000 35.20627  ? 102 VAL B CG1 1 
ATOM   2782 C  CG2 . VAL B 1 104 ? -36.04019 47.88781 -50.75155 1.000 35.55165  ? 102 VAL B CG2 1 
ATOM   2783 N  N   . ARG B 1 105 ? -35.36142 43.80614 -50.48065 1.000 37.78122  ? 103 ARG B N   1 
ATOM   2784 C  CA  . ARG B 1 105 ? -36.06223 42.76946 -49.73883 1.000 40.65316  ? 103 ARG B CA  1 
ATOM   2785 C  C   . ARG B 1 105 ? -35.29528 42.29929 -48.50772 1.000 39.37839  ? 103 ARG B C   1 
ATOM   2786 O  O   . ARG B 1 105 ? -35.92380 41.81830 -47.56333 1.000 41.65621  ? 103 ARG B O   1 
ATOM   2787 C  CB  . ARG B 1 105 ? -36.36821 41.60448 -50.66844 1.000 36.87047  ? 103 ARG B CB  1 
ATOM   2788 C  CG  . ARG B 1 105 ? -37.37284 42.00655 -51.70093 1.000 42.33953  ? 103 ARG B CG  1 
ATOM   2789 C  CD  . ARG B 1 105 ? -37.77872 40.84252 -52.53220 1.000 47.57487  ? 103 ARG B CD  1 
ATOM   2790 N  NE  . ARG B 1 105 ? -38.62903 39.98230 -51.73751 1.000 60.11108  ? 103 ARG B NE  1 
ATOM   2791 C  CZ  . ARG B 1 105 ? -39.20000 38.88214 -52.18807 1.000 59.57557  ? 103 ARG B CZ  1 
ATOM   2792 N  NH1 . ARG B 1 105 ? -39.00442 38.46878 -53.43303 1.000 62.84459  ? 103 ARG B NH1 1 
ATOM   2793 N  NH2 . ARG B 1 105 ? -40.00106 38.19270 -51.37462 1.000 57.86059  ? 103 ARG B NH2 1 
ATOM   2794 N  N   . LEU B 1 106 ? -33.96514 42.45270 -48.47780 1.000 41.55340  ? 104 LEU B N   1 
ATOM   2795 C  CA  . LEU B 1 106 ? -33.21442 42.18996 -47.24835 1.000 37.54837  ? 104 LEU B CA  1 
ATOM   2796 C  C   . LEU B 1 106 ? -33.67662 43.09955 -46.12019 1.000 39.56947  ? 104 LEU B C   1 
ATOM   2797 O  O   . LEU B 1 106 ? -33.85066 42.65309 -44.97710 1.000 40.72961  ? 104 LEU B O   1 
ATOM   2798 C  CB  . LEU B 1 106 ? -31.72109 42.39439 -47.48853 1.000 43.04977  ? 104 LEU B CB  1 
ATOM   2799 C  CG  . LEU B 1 106 ? -30.88585 41.23391 -48.02435 1.000 43.22222  ? 104 LEU B CG  1 
ATOM   2800 C  CD1 . LEU B 1 106 ? -29.46354 41.63476 -47.97843 1.000 40.65805  ? 104 LEU B CD1 1 
ATOM   2801 C  CD2 . LEU B 1 106 ? -31.07647 39.96604 -47.22456 1.000 43.91175  ? 104 LEU B CD2 1 
ATOM   2802 N  N   . LEU B 1 107 ? -33.86974 44.38649 -46.42034 1.000 38.89848  ? 105 LEU B N   1 
ATOM   2803 C  CA  . LEU B 1 107 ? -34.38907 45.30753 -45.41982 1.000 39.65836  ? 105 LEU B CA  1 
ATOM   2804 C  C   . LEU B 1 107 ? -35.78272 44.88127 -44.95960 1.000 41.04432  ? 105 LEU B C   1 
ATOM   2805 O  O   . LEU B 1 107 ? -36.04382 44.75246 -43.75484 1.000 44.82197  ? 105 LEU B O   1 
ATOM   2806 C  CB  . LEU B 1 107 ? -34.38574 46.72308 -45.98816 1.000 41.10478  ? 105 LEU B CB  1 
ATOM   2807 C  CG  . LEU B 1 107 ? -32.98663 47.30168 -46.17015 1.000 39.53207  ? 105 LEU B CG  1 
ATOM   2808 C  CD1 . LEU B 1 107 ? -33.06248 48.76035 -46.49219 1.000 44.15240  ? 105 LEU B CD1 1 
ATOM   2809 C  CD2 . LEU B 1 107 ? -32.16388 47.10532 -44.91171 1.000 41.00803  ? 105 LEU B CD2 1 
ATOM   2810 N  N   . THR B 1 108 ? -36.68074 44.61617 -45.90732 1.000 40.25167  ? 106 THR B N   1 
ATOM   2811 C  CA  . THR B 1 108 ? -38.02548 44.17167 -45.54767 1.000 45.37796  ? 106 THR B CA  1 
ATOM   2812 C  C   . THR B 1 108 ? -37.98592 42.97309 -44.60753 1.000 45.84169  ? 106 THR B C   1 
ATOM   2813 O  O   . THR B 1 108 ? -38.72930 42.92168 -43.62366 1.000 41.29367  ? 106 THR B O   1 
ATOM   2814 C  CB  . THR B 1 108 ? -38.81115 43.81432 -46.80668 1.000 43.34466  ? 106 THR B CB  1 
ATOM   2815 O  OG1 . THR B 1 108 ? -38.73736 44.90190 -47.73626 1.000 48.56117  ? 106 THR B OG1 1 
ATOM   2816 C  CG2 . THR B 1 108 ? -40.23678 43.54713 -46.45866 1.000 39.76133  ? 106 THR B CG2 1 
ATOM   2817 N  N   . ASP B 1 109 ? -37.11549 41.99991 -44.89120 1.000 44.09460  ? 107 ASP B N   1 
ATOM   2818 C  CA  . ASP B 1 109 ? -37.10878 40.76315 -44.11667 1.000 40.41938  ? 107 ASP B CA  1 
ATOM   2819 C  C   . ASP B 1 109 ? -36.34566 40.86400 -42.79786 1.000 35.97768  ? 107 ASP B C   1 
ATOM   2820 O  O   . ASP B 1 109 ? -36.65237 40.11438 -41.86988 1.000 42.64866  ? 107 ASP B O   1 
ATOM   2821 C  CB  . ASP B 1 109 ? -36.55524 39.61533 -44.97735 1.000 41.44398  ? 107 ASP B CB  1 
ATOM   2822 C  CG  . ASP B 1 109 ? -37.45909 39.30875 -46.16326 1.000 57.36960  ? 107 ASP B CG  1 
ATOM   2823 O  OD1 . ASP B 1 109 ? -37.00789 38.69363 -47.15978 1.000 59.48324  ? 107 ASP B OD1 1 
ATOM   2824 O  OD2 . ASP B 1 109 ? -38.65265 39.68875 -46.08175 1.000 56.88473  ? 107 ASP B OD2 1 
ATOM   2825 N  N   . HIS B 1 110 ? -35.34560 41.73578 -42.68119 1.000 35.73693  ? 108 HIS B N   1 
ATOM   2826 C  CA  . HIS B 1 110 ? -34.46501 41.67575 -41.51586 1.000 38.86569  ? 108 HIS B CA  1 
ATOM   2827 C  C   . HIS B 1 110 ? -34.21007 43.01414 -40.83378 1.000 38.47601  ? 108 HIS B C   1 
ATOM   2828 O  O   . HIS B 1 110 ? -33.54829 43.02400 -39.79744 1.000 40.46455  ? 108 HIS B O   1 
ATOM   2829 C  CB  . HIS B 1 110 ? -33.09621 41.06208 -41.89649 1.000 36.33391  ? 108 HIS B CB  1 
ATOM   2830 C  CG  . HIS B 1 110 ? -33.20012 39.74904 -42.60997 1.000 38.27528  ? 108 HIS B CG  1 
ATOM   2831 N  ND1 . HIS B 1 110 ? -33.59901 38.58778 -41.98306 1.000 46.18184  ? 108 HIS B ND1 1 
ATOM   2832 C  CD2 . HIS B 1 110 ? -33.01771 39.42695 -43.91546 1.000 40.42142  ? 108 HIS B CD2 1 
ATOM   2833 C  CE1 . HIS B 1 110 ? -33.63507 37.60215 -42.86248 1.000 39.81574  ? 108 HIS B CE1 1 
ATOM   2834 N  NE2 . HIS B 1 110 ? -33.28225 38.08438 -44.04319 1.000 44.79008  ? 108 HIS B NE2 1 
ATOM   2835 N  N   . LEU B 1 111 ? -34.65796 44.13874 -41.38929 1.000 39.63833  ? 109 LEU B N   1 
ATOM   2836 C  CA  . LEU B 1 111 ? -34.44875 45.40015 -40.68285 1.000 42.09056  ? 109 LEU B CA  1 
ATOM   2837 C  C   . LEU B 1 111 ? -35.58871 45.58214 -39.69406 1.000 40.03874  ? 109 LEU B C   1 
ATOM   2838 O  O   . LEU B 1 111 ? -36.74613 45.70418 -40.11694 1.000 43.98864  ? 109 LEU B O   1 
ATOM   2839 C  CB  . LEU B 1 111 ? -34.40251 46.58889 -41.64459 1.000 40.72454  ? 109 LEU B CB  1 
ATOM   2840 C  CG  . LEU B 1 111 ? -34.16713 47.96720 -41.00682 1.000 44.66711  ? 109 LEU B CG  1 
ATOM   2841 C  CD1 . LEU B 1 111 ? -32.77429 48.04886 -40.44874 1.000 38.90487  ? 109 LEU B CD1 1 
ATOM   2842 C  CD2 . LEU B 1 111 ? -34.39343 49.10010 -42.01894 1.000 43.37048  ? 109 LEU B CD2 1 
ATOM   2843 N  N   . PRO B 1 112 ? -35.32232 45.60610 -38.39058 1.000 43.74766  ? 110 PRO B N   1 
ATOM   2844 C  CA  . PRO B 1 112 ? -36.41733 45.81220 -37.43195 1.000 36.90874  ? 110 PRO B CA  1 
ATOM   2845 C  C   . PRO B 1 112 ? -36.96795 47.22642 -37.55515 1.000 38.30276  ? 110 PRO B C   1 
ATOM   2846 O  O   . PRO B 1 112 ? -36.21587 48.20372 -37.55894 1.000 40.82034  ? 110 PRO B O   1 
ATOM   2847 C  CB  . PRO B 1 112 ? -35.75393 45.57010 -36.06500 1.000 38.95556  ? 110 PRO B CB  1 
ATOM   2848 C  CG  . PRO B 1 112 ? -34.38845 44.96224 -36.35851 1.000 37.56318  ? 110 PRO B CG  1 
ATOM   2849 C  CD  . PRO B 1 112 ? -34.01120 45.49134 -37.71743 1.000 41.19970  ? 110 PRO B CD  1 
ATOM   2850 N  N   . GLN B 1 113 ? -38.29391 47.33095 -37.66006 1.000 38.54885  ? 111 GLN B N   1 
ATOM   2851 C  CA  . GLN B 1 113 ? -38.91632 48.64627 -37.71194 1.000 38.98409  ? 111 GLN B CA  1 
ATOM   2852 C  C   . GLN B 1 113 ? -38.46103 49.50125 -36.53876 1.000 43.19953  ? 111 GLN B C   1 
ATOM   2853 O  O   . GLN B 1 113 ? -38.19771 50.70408 -36.69084 1.000 40.76181  ? 111 GLN B O   1 
ATOM   2854 C  CB  . GLN B 1 113 ? -40.43854 48.52002 -37.71904 1.000 36.31399  ? 111 GLN B CB  1 
ATOM   2855 C  CG  . GLN B 1 113 ? -41.11800 49.83454 -37.39870 1.000 42.86717  ? 111 GLN B CG  1 
ATOM   2856 C  CD  . GLN B 1 113 ? -42.61578 49.77502 -37.53406 1.000 42.45621  ? 111 GLN B CD  1 
ATOM   2857 O  OE1 . GLN B 1 113 ? -43.25960 48.80952 -37.11061 1.000 45.92836  ? 111 GLN B OE1 1 
ATOM   2858 N  NE2 . GLN B 1 113 ? -43.18166 50.79634 -38.14818 1.000 36.03768  ? 111 GLN B NE2 1 
ATOM   2859 N  N   . HIS B 1 114 ? -38.29760 48.87940 -35.37078 1.000 35.14143  ? 112 HIS B N   1 
ATOM   2860 C  CA  . HIS B 1 114 ? -37.93677 49.65436 -34.18920 1.000 44.37604  ? 112 HIS B CA  1 
ATOM   2861 C  C   . HIS B 1 114 ? -36.53176 50.23572 -34.30616 1.000 42.07272  ? 112 HIS B C   1 
ATOM   2862 O  O   . HIS B 1 114 ? -36.29253 51.36862 -33.87347 1.000 46.19870  ? 112 HIS B O   1 
ATOM   2863 C  CB  . HIS B 1 114 ? -38.09487 48.79046 -32.93318 1.000 39.44719  ? 112 HIS B CB  1 
ATOM   2864 C  CG  . HIS B 1 114 ? -38.00517 49.56065 -31.65684 1.000 45.05444  ? 112 HIS B CG  1 
ATOM   2865 N  ND1 . HIS B 1 114 ? -36.79890 49.89840 -31.07720 1.000 51.25190  ? 112 HIS B ND1 1 
ATOM   2866 C  CD2 . HIS B 1 114 ? -38.96773 50.06742 -30.84776 1.000 43.76324  ? 112 HIS B CD2 1 
ATOM   2867 C  CE1 . HIS B 1 114 ? -37.02266 50.57394 -29.96260 1.000 50.59024  ? 112 HIS B CE1 1 
ATOM   2868 N  NE2 . HIS B 1 114 ? -38.33020 50.69424 -29.80423 1.000 50.41078  ? 112 HIS B NE2 1 
ATOM   2869 N  N   . SER B 1 115 ? -35.58826 49.48229 -34.88516 1.000 42.77409  ? 113 SER B N   1 
ATOM   2870 C  CA  . SER B 1 115 ? -34.25731 50.03515 -35.13362 1.000 43.98144  ? 113 SER B CA  1 
ATOM   2871 C  C   . SER B 1 115 ? -34.33039 51.18740 -36.11862 1.000 43.67992  ? 113 SER B C   1 
ATOM   2872 O  O   . SER B 1 115 ? -33.69005 52.22567 -35.92553 1.000 53.11998  ? 113 SER B O   1 
ATOM   2873 C  CB  . SER B 1 115 ? -33.31099 48.96248 -35.67362 1.000 43.63190  ? 113 SER B CB  1 
ATOM   2874 O  OG  . SER B 1 115 ? -33.19458 47.87739 -34.77197 1.000 50.96952  ? 113 SER B OG  1 
ATOM   2875 N  N   . LEU B 1 116 ? -35.08488 51.00628 -37.20272 1.000 41.04960  ? 114 LEU B N   1 
ATOM   2876 C  CA  . LEU B 1 116 ? -35.18045 52.04799 -38.21887 1.000 41.87575  ? 114 LEU B CA  1 
ATOM   2877 C  C   . LEU B 1 116 ? -35.74094 53.33552 -37.61912 1.000 45.84841  ? 114 LEU B C   1 
ATOM   2878 O  O   . LEU B 1 116 ? -35.18617 54.41638 -37.82569 1.000 45.32553  ? 114 LEU B O   1 
ATOM   2879 C  CB  . LEU B 1 116 ? -36.03393 51.54674 -39.38637 1.000 40.37807  ? 114 LEU B CB  1 
ATOM   2880 C  CG  . LEU B 1 116 ? -36.28841 52.44700 -40.60492 1.000 47.81893  ? 114 LEU B CG  1 
ATOM   2881 C  CD1 . LEU B 1 116 ? -37.47156 53.40768 -40.36348 1.000 38.10491  ? 114 LEU B CD1 1 
ATOM   2882 C  CD2 . LEU B 1 116 ? -35.02714 53.20565 -41.04690 1.000 38.03477  ? 114 LEU B CD2 1 
ATOM   2883 N  N   . LEU B 1 117 ? -36.81692 53.22922 -36.82796 1.000 47.14737  ? 115 LEU B N   1 
ATOM   2884 C  CA  . LEU B 1 117 ? -37.41972 54.41741 -36.22851 1.000 44.27795  ? 115 LEU B CA  1 
ATOM   2885 C  C   . LEU B 1 117 ? -36.44467 55.12566 -35.29480 1.000 52.81342  ? 115 LEU B C   1 
ATOM   2886 O  O   . LEU B 1 117 ? -36.36360 56.35814 -35.30075 1.000 50.66623  ? 115 LEU B O   1 
ATOM   2887 C  CB  . LEU B 1 117 ? -38.70707 54.04718 -35.49284 1.000 35.51176  ? 115 LEU B CB  1 
ATOM   2888 C  CG  . LEU B 1 117 ? -39.77996 53.57897 -36.47149 1.000 43.20841  ? 115 LEU B CG  1 
ATOM   2889 C  CD1 . LEU B 1 117 ? -40.99349 53.01298 -35.76377 1.000 35.08740  ? 115 LEU B CD1 1 
ATOM   2890 C  CD2 . LEU B 1 117 ? -40.17757 54.70093 -37.40408 1.000 40.53599  ? 115 LEU B CD2 1 
ATOM   2891 N  N   . MET B 1 118 ? -35.67871 54.37058 -34.50091 1.000 51.25958  ? 116 MET B N   1 
ATOM   2892 C  CA  . MET B 1 118 ? -34.67445 55.00448 -33.64463 1.000 53.03527  ? 116 MET B CA  1 
ATOM   2893 C  C   . MET B 1 118 ? -33.59775 55.67910 -34.48777 1.000 54.59249  ? 116 MET B C   1 
ATOM   2894 O  O   . MET B 1 118 ? -33.25117 56.83804 -34.24779 1.000 59.56191  ? 116 MET B O   1 
ATOM   2895 C  CB  . MET B 1 118 ? -34.04568 53.97474 -32.70849 1.000 44.73614  ? 116 MET B CB  1 
ATOM   2896 C  CG  . MET B 1 118 ? -35.08399 53.28339 -31.86294 1.000 57.05864  ? 116 MET B CG  1 
ATOM   2897 S  SD  . MET B 1 118 ? -35.95211 54.36366 -30.69978 1.000 60.81905  ? 116 MET B SD  1 
ATOM   2898 C  CE  . MET B 1 118 ? -37.64365 54.31244 -31.33894 1.000 44.68223  ? 116 MET B CE  1 
ATOM   2899 N  N   . MET B 1 119 ? -33.05737 54.96764 -35.48895 1.000 59.56166  ? 117 MET B N   1 
ATOM   2900 C  CA  . MET B 1 119 ? -32.08877 55.58612 -36.39828 1.000 60.46380  ? 117 MET B CA  1 
ATOM   2901 C  C   . MET B 1 119 ? -32.66877 56.82610 -37.05992 1.000 57.48797  ? 117 MET B C   1 
ATOM   2902 O  O   . MET B 1 119 ? -32.06261 57.90053 -37.02351 1.000 63.09997  ? 117 MET B O   1 
ATOM   2903 C  CB  . MET B 1 119 ? -31.60781 54.61346 -37.48283 1.000 47.03909  ? 117 MET B CB  1 
ATOM   2904 C  CG  . MET B 1 119 ? -30.28594 53.89019 -37.22555 1.000 56.02845  ? 117 MET B CG  1 
ATOM   2905 S  SD  . MET B 1 119 ? -30.15618 52.17027 -37.82064 1.000 59.80876  ? 117 MET B SD  1 
ATOM   2906 C  CE  . MET B 1 119 ? -30.84606 52.25870 -39.44664 1.000 52.50347  ? 117 MET B CE  1 
ATOM   2907 N  N   . ARG B 1 120 ? -33.84101 56.68680 -37.68232 1.000 52.28850  ? 118 ARG B N   1 
ATOM   2908 C  CA  . ARG B 1 120 ? -34.47516 57.80121 -38.38258 1.000 57.48361  ? 118 ARG B CA  1 
ATOM   2909 C  C   . ARG B 1 120 ? -34.73282 58.98421 -37.45740 1.000 64.60194  ? 118 ARG B C   1 
ATOM   2910 O  O   . ARG B 1 120 ? -34.66892 60.13757 -37.89247 1.000 68.43221  ? 118 ARG B O   1 
ATOM   2911 C  CB  . ARG B 1 120 ? -35.76347 57.30480 -39.02970 1.000 56.22786  ? 118 ARG B CB  1 
ATOM   2912 C  CG  . ARG B 1 120 ? -36.57907 58.31522 -39.75160 1.000 49.69137  ? 118 ARG B CG  1 
ATOM   2913 C  CD  . ARG B 1 120 ? -37.74347 57.60909 -40.40771 1.000 50.49302  ? 118 ARG B CD  1 
ATOM   2914 N  NE  . ARG B 1 120 ? -38.30762 58.39225 -41.49989 1.000 67.11236  ? 118 ARG B NE  1 
ATOM   2915 C  CZ  . ARG B 1 120 ? -39.25807 59.30787 -41.35850 1.000 66.37043  ? 118 ARG B CZ  1 
ATOM   2916 N  NH1 . ARG B 1 120 ? -39.75958 59.60603 -40.16679 1.000 47.79209  ? 118 ARG B NH1 1 
ATOM   2917 N  NH2 . ARG B 1 120 ? -39.73094 59.92539 -42.44341 1.000 65.23199  ? 118 ARG B NH2 1 
ATOM   2918 N  N   . ASN B 1 121 ? -34.98777 58.72432 -36.17662 1.000 62.96080  ? 119 ASN B N   1 
ATOM   2919 C  CA  . ASN B 1 121 ? -35.20045 59.77246 -35.18774 1.000 64.03066  ? 119 ASN B CA  1 
ATOM   2920 C  C   . ASN B 1 121 ? -33.93548 60.58206 -34.92598 1.000 74.32551  ? 119 ASN B C   1 
ATOM   2921 O  O   . ASN B 1 121 ? -33.94264 61.46037 -34.05752 1.000 79.58233  ? 119 ASN B O   1 
ATOM   2922 C  CB  . ASN B 1 121 ? -35.70085 59.14309 -33.88141 1.000 59.89571  ? 119 ASN B CB  1 
ATOM   2923 C  CG  . ASN B 1 121 ? -37.21849 59.03227 -33.82448 1.000 60.92421  ? 119 ASN B CG  1 
ATOM   2924 O  OD1 . ASN B 1 121 ? -37.92687 59.47077 -34.74116 1.000 60.10004  ? 119 ASN B OD1 1 
ATOM   2925 N  ND2 . ASN B 1 121 ? -37.71954 58.36445 -32.79159 1.000 50.79621  ? 119 ASN B ND2 1 
ATOM   2926 N  N   . ALA B 1 122 ? -32.84440 60.28184 -35.63480 1.000 79.93754  ? 120 ALA B N   1 
ATOM   2927 C  CA  . ALA B 1 122 ? -31.60941 61.03928 -35.52909 1.000 79.29412  ? 120 ALA B CA  1 
ATOM   2928 C  C   . ALA B 1 122 ? -31.01617 61.44760 -36.87231 1.000 76.51581  ? 120 ALA B C   1 
ATOM   2929 O  O   . ALA B 1 122 ? -29.99935 62.14599 -36.87551 1.000 85.66923  ? 120 ALA B O   1 
ATOM   2930 C  CB  . ALA B 1 122 ? -30.56075 60.24272 -34.74032 1.000 64.66609  ? 120 ALA B CB  1 
ATOM   2931 N  N   . LEU B 1 123 ? -31.60800 61.03797 -38.00796 1.000 81.34598  ? 121 LEU B N   1 
ATOM   2932 C  CA  . LEU B 1 123 ? -31.09748 61.42551 -39.32085 1.000 88.20706  ? 121 LEU B CA  1 
ATOM   2933 C  C   . LEU B 1 123 ? -31.26677 62.92796 -39.53597 1.000 99.08793  ? 121 LEU B C   1 
ATOM   2934 O  O   . LEU B 1 123 ? -32.07204 63.57775 -38.85999 1.000 103.11372 ? 121 LEU B O   1 
ATOM   2935 C  CB  . LEU B 1 123 ? -31.81532 60.67829 -40.45291 1.000 85.70393  ? 121 LEU B CB  1 
ATOM   2936 C  CG  . LEU B 1 123 ? -31.69691 59.17377 -40.76077 1.000 89.12277  ? 121 LEU B CG  1 
ATOM   2937 C  CD1 . LEU B 1 123 ? -32.71230 58.76058 -41.84076 1.000 79.27341  ? 121 LEU B CD1 1 
ATOM   2938 C  CD2 . LEU B 1 123 ? -30.28070 58.77484 -41.19006 1.000 83.23881  ? 121 LEU B CD2 1 
ATOM   2939 N  N   . PRO B 1 124 ? -30.49722 63.50336 -40.48634 1.000 105.69572 ? 122 PRO B N   1 
ATOM   2940 C  CA  . PRO B 1 124 ? -30.67277 64.91726 -40.86751 1.000 107.41251 ? 122 PRO B CA  1 
ATOM   2941 C  C   . PRO B 1 124 ? -32.08577 65.33175 -41.26276 1.000 107.23908 ? 122 PRO B C   1 
ATOM   2942 O  O   . PRO B 1 124 ? -32.25034 66.43600 -41.79292 1.000 104.15268 ? 122 PRO B O   1 
ATOM   2943 C  CB  . PRO B 1 124 ? -29.73927 65.04692 -42.08516 1.000 101.84810 ? 122 PRO B CB  1 
ATOM   2944 C  CG  . PRO B 1 124 ? -28.63250 64.01189 -41.84983 1.000 95.20555  ? 122 PRO B CG  1 
ATOM   2945 C  CD  . PRO B 1 124 ? -29.09394 63.08334 -40.72402 1.000 102.82755 ? 122 PRO B CD  1 
ATOM   2946 N  N   . GLU B 1 125 ? -33.09500 64.47406 -41.03935 1.000 107.94507 ? 123 GLU B N   1 
ATOM   2947 C  CA  . GLU B 1 125 ? -34.49311 64.70806 -41.41695 1.000 116.87275 ? 123 GLU B CA  1 
ATOM   2948 C  C   . GLU B 1 125 ? -34.57743 65.30800 -42.81889 1.000 119.74549 ? 123 GLU B C   1 
ATOM   2949 O  O   . GLU B 1 125 ? -35.52117 66.03440 -43.15273 1.000 119.98143 ? 123 GLU B O   1 
ATOM   2950 C  CB  . GLU B 1 125 ? -35.20796 65.59985 -40.38671 1.000 114.27261 ? 123 GLU B CB  1 
ATOM   2951 C  CG  . GLU B 1 125 ? -34.99502 65.21701 -38.89834 1.000 115.39397 ? 123 GLU B CG  1 
ATOM   2952 C  CD  . GLU B 1 125 ? -35.85845 64.03677 -38.40651 1.000 114.29353 ? 123 GLU B CD  1 
ATOM   2953 O  OE1 . GLU B 1 125 ? -37.09705 64.01825 -38.62559 1.000 104.26976 ? 123 GLU B OE1 1 
ATOM   2954 O  OE2 . GLU B 1 125 ? -35.27961 63.12483 -37.77610 1.000 103.21052 ? 123 GLU B OE2 1 
ATOM   2955 N  N   . ASP B 1 126 ? -33.57623 64.98193 -43.63824 1.000 115.94137 ? 124 ASP B N   1 
ATOM   2956 C  CA  . ASP B 1 126 ? -33.37817 65.50929 -44.98026 1.000 108.75534 ? 124 ASP B CA  1 
ATOM   2957 C  C   . ASP B 1 126 ? -32.81112 64.46500 -45.92343 1.000 99.70834  ? 124 ASP B C   1 
ATOM   2958 O  O   . ASP B 1 126 ? -32.75309 64.70816 -47.13316 1.000 91.38621  ? 124 ASP B O   1 
ATOM   2959 C  CB  . ASP B 1 126 ? -32.41936 66.70587 -44.94629 1.000 106.74648 ? 124 ASP B CB  1 
ATOM   2960 C  CG  . ASP B 1 126 ? -32.63543 67.65866 -46.09666 1.000 116.47127 ? 124 ASP B CG  1 
ATOM   2961 O  OD1 . ASP B 1 126 ? -33.13983 67.22429 -47.15680 1.000 114.19715 ? 124 ASP B OD1 1 
ATOM   2962 O  OD2 . ASP B 1 126 ? -32.28243 68.84798 -45.94244 1.000 119.38778 ? 124 ASP B OD2 1 
ATOM   2963 N  N   . ALA B 1 127 ? -32.36720 63.32762 -45.41174 1.000 90.82365  ? 125 ALA B N   1 
ATOM   2964 C  CA  . ALA B 1 127 ? -31.80520 62.27709 -46.24115 1.000 81.70185  ? 125 ALA B CA  1 
ATOM   2965 C  C   . ALA B 1 127 ? -32.95137 61.56315 -46.94974 1.000 82.71579  ? 125 ALA B C   1 
ATOM   2966 O  O   . ALA B 1 127 ? -33.67194 60.75891 -46.34994 1.000 89.90725  ? 125 ALA B O   1 
ATOM   2967 C  CB  . ALA B 1 127 ? -30.97569 61.33574 -45.37765 1.000 76.43862  ? 125 ALA B CB  1 
ATOM   2968 N  N   . THR B 1 128 ? -33.13675 61.87468 -48.23139 1.000 70.39729  ? 126 THR B N   1 
ATOM   2969 C  CA  . THR B 1 128 ? -34.19131 61.29571 -49.05319 1.000 69.74988  ? 126 THR B CA  1 
ATOM   2970 C  C   . THR B 1 128 ? -33.59131 60.54675 -50.24465 1.000 67.29427  ? 126 THR B C   1 
ATOM   2971 O  O   . THR B 1 128 ? -32.65769 61.03266 -50.89498 1.000 56.29557  ? 126 THR B O   1 
ATOM   2972 C  CB  . THR B 1 128 ? -35.15325 62.38679 -49.55122 1.000 70.32418  ? 126 THR B CB  1 
ATOM   2973 O  OG1 . THR B 1 128 ? -35.98595 61.86496 -50.59617 1.000 72.20042  ? 126 THR B OG1 1 
ATOM   2974 C  CG2 . THR B 1 128 ? -34.37727 63.59648 -50.09017 1.000 63.14554  ? 126 THR B CG2 1 
ATOM   2975 N  N   . GLY B 1 129 ? -34.13879 59.36445 -50.53903 1.000 66.02627  ? 127 GLY B N   1 
ATOM   2976 C  CA  . GLY B 1 129 ? -33.74883 58.62756 -51.73886 1.000 57.50042  ? 127 GLY B CA  1 
ATOM   2977 C  C   . GLY B 1 129 ? -34.00477 59.37074 -53.04108 1.000 60.06067  ? 127 GLY B C   1 
ATOM   2978 O  O   . GLY B 1 129 ? -33.47977 58.96681 -54.08698 1.000 55.19876  ? 127 GLY B O   1 
ATOM   2979 N  N   . LEU B 1 130 ? -34.79523 60.44443 -53.00725 1.000 60.23600  ? 128 LEU B N   1 
ATOM   2980 C  CA  . LEU B 1 130 ? -34.93575 61.28986 -54.18522 1.000 62.05060  ? 128 LEU B CA  1 
ATOM   2981 C  C   . LEU B 1 130 ? -33.59020 61.83771 -54.64784 1.000 57.56382  ? 128 LEU B C   1 
ATOM   2982 O  O   . LEU B 1 130 ? -33.45351 62.21481 -55.81332 1.000 57.59769  ? 128 LEU B O   1 
ATOM   2983 C  CB  . LEU B 1 130 ? -35.91362 62.42536 -53.87856 1.000 65.39580  ? 128 LEU B CB  1 
ATOM   2984 C  CG  . LEU B 1 130 ? -37.38653 61.99455 -53.91188 1.000 74.87843  ? 128 LEU B CG  1 
ATOM   2985 C  CD1 . LEU B 1 130 ? -38.28305 63.00350 -53.21060 1.000 74.51059  ? 128 LEU B CD1 1 
ATOM   2986 C  CD2 . LEU B 1 130 ? -37.85600 61.76046 -55.34753 1.000 72.60544  ? 128 LEU B CD2 1 
ATOM   2987 N  N   . ASP B 1 131 ? -32.58749 61.85823 -53.77122 1.000 57.11432  ? 129 ASP B N   1 
ATOM   2988 C  CA  . ASP B 1 131 ? -31.25786 62.34800 -54.09970 1.000 54.36112  ? 129 ASP B CA  1 
ATOM   2989 C  C   . ASP B 1 131 ? -30.30943 61.24932 -54.56090 1.000 52.81030  ? 129 ASP B C   1 
ATOM   2990 O  O   . ASP B 1 131 ? -29.13958 61.53758 -54.83000 1.000 56.90667  ? 129 ASP B O   1 
ATOM   2991 C  CB  . ASP B 1 131 ? -30.65869 63.05675 -52.88487 1.000 63.59881  ? 129 ASP B CB  1 
ATOM   2992 C  CG  . ASP B 1 131 ? -31.13453 64.49247 -52.75142 1.000 69.87485  ? 129 ASP B CG  1 
ATOM   2993 O  OD1 . ASP B 1 131 ? -31.12249 65.22749 -53.76576 1.000 77.42337  ? 129 ASP B OD1 1 
ATOM   2994 O  OD2 . ASP B 1 131 ? -31.51223 64.88273 -51.62346 1.000 74.26884  ? 129 ASP B OD2 1 
ATOM   2995 N  N   . SER B 1 132 ? -30.77382 60.00567 -54.62934 1.000 55.36072  ? 130 SER B N   1 
ATOM   2996 C  CA  . SER B 1 132 ? -29.94851 58.88018 -55.04969 1.000 51.30369  ? 130 SER B CA  1 
ATOM   2997 C  C   . SER B 1 132 ? -29.36965 59.12511 -56.43606 1.000 46.41638  ? 130 SER B C   1 
ATOM   2998 O  O   . SER B 1 132 ? -30.13231 59.34597 -57.38919 1.000 44.66254  ? 130 SER B O   1 
ATOM   2999 C  CB  . SER B 1 132 ? -30.77521 57.59730 -55.05100 1.000 42.52436  ? 130 SER B CB  1 
ATOM   3000 O  OG  . SER B 1 132 ? -30.21376 56.62650 -55.89854 1.000 43.33738  ? 130 SER B OG  1 
ATOM   3001 N  N   . PRO B 1 133 ? -28.04994 59.08928 -56.59857 1.000 49.75676  ? 131 PRO B N   1 
ATOM   3002 C  CA  . PRO B 1 133 ? -27.47559 59.23608 -57.95349 1.000 46.14383  ? 131 PRO B CA  1 
ATOM   3003 C  C   . PRO B 1 133 ? -27.86936 58.10780 -58.88838 1.000 48.74767  ? 131 PRO B C   1 
ATOM   3004 O  O   . PRO B 1 133 ? -28.21043 58.35777 -60.05291 1.000 49.08005  ? 131 PRO B O   1 
ATOM   3005 C  CB  . PRO B 1 133 ? -25.96180 59.25903 -57.70574 1.000 40.46615  ? 131 PRO B CB  1 
ATOM   3006 C  CG  . PRO B 1 133 ? -25.79652 59.43533 -56.22851 1.000 53.22179  ? 131 PRO B CG  1 
ATOM   3007 C  CD  . PRO B 1 133 ? -27.03543 58.93990 -55.55205 1.000 46.35248  ? 131 PRO B CD  1 
ATOM   3008 N  N   . GLY B 1 134 ? -27.85095 56.86462 -58.40342 1.000 49.42941  ? 132 GLY B N   1 
ATOM   3009 C  CA  . GLY B 1 134 ? -28.25410 55.75520 -59.24876 1.000 45.48820  ? 132 GLY B CA  1 
ATOM   3010 C  C   . GLY B 1 134 ? -29.65752 55.93187 -59.79411 1.000 45.55255  ? 132 GLY B C   1 
ATOM   3011 O  O   . GLY B 1 134 ? -29.91207 55.72369 -60.98084 1.000 49.55380  ? 132 GLY B O   1 
ATOM   3012 N  N   . TYR B 1 135 ? -30.58480 56.35123 -58.94247 1.000 46.01779  ? 133 TYR B N   1 
ATOM   3013 C  CA  . TYR B 1 135 ? -31.96005 56.48559 -59.40419 1.000 51.05630  ? 133 TYR B CA  1 
ATOM   3014 C  C   . TYR B 1 135 ? -32.13149 57.64486 -60.38351 1.000 48.33365  ? 133 TYR B C   1 
ATOM   3015 O  O   . TYR B 1 135 ? -32.81786 57.50818 -61.40375 1.000 43.63470  ? 133 TYR B O   1 
ATOM   3016 C  CB  . TYR B 1 135 ? -32.89160 56.67597 -58.22778 1.000 49.49464  ? 133 TYR B CB  1 
ATOM   3017 C  CG  . TYR B 1 135 ? -34.28992 56.32393 -58.60372 1.000 59.87476  ? 133 TYR B CG  1 
ATOM   3018 C  CD1 . TYR B 1 135 ? -34.60376 55.06101 -59.13182 1.000 66.31839  ? 133 TYR B CD1 1 
ATOM   3019 C  CD2 . TYR B 1 135 ? -35.28753 57.28726 -58.53828 1.000 55.18403  ? 133 TYR B CD2 1 
ATOM   3020 C  CE1 . TYR B 1 135 ? -35.90679 54.75176 -59.51427 1.000 72.51212  ? 133 TYR B CE1 1 
ATOM   3021 C  CE2 . TYR B 1 135 ? -36.58189 56.99662 -58.91485 1.000 66.97267  ? 133 TYR B CE2 1 
ATOM   3022 C  CZ  . TYR B 1 135 ? -36.89167 55.73618 -59.40001 1.000 78.03355  ? 133 TYR B CZ  1 
ATOM   3023 O  OH  . TYR B 1 135 ? -38.19684 55.49057 -59.76106 1.000 89.45792  ? 133 TYR B OH  1 
ATOM   3024 N  N   . ARG B 1 136 ? -31.56808 58.81246 -60.05903 1.000 45.26174  ? 134 ARG B N   1 
ATOM   3025 C  CA  . ARG B 1 136 ? -31.70306 59.96866 -60.93962 1.000 45.52571  ? 134 ARG B CA  1 
ATOM   3026 C  C   . ARG B 1 136 ? -31.08892 59.68650 -62.31120 1.000 54.26626  ? 134 ARG B C   1 
ATOM   3027 O  O   . ARG B 1 136 ? -31.69622 59.97812 -63.34631 1.000 51.32279  ? 134 ARG B O   1 
ATOM   3028 C  CB  . ARG B 1 136 ? -31.04380 61.19115 -60.30922 1.000 46.84565  ? 134 ARG B CB  1 
ATOM   3029 C  CG  . ARG B 1 136 ? -31.80876 61.81331 -59.16168 1.000 53.68104  ? 134 ARG B CG  1 
ATOM   3030 C  CD  . ARG B 1 136 ? -30.83061 62.47267 -58.18421 1.000 59.96634  ? 134 ARG B CD  1 
ATOM   3031 N  NE  . ARG B 1 136 ? -30.41627 63.78676 -58.65658 1.000 79.24147  ? 134 ARG B NE  1 
ATOM   3032 C  CZ  . ARG B 1 136 ? -31.17416 64.87492 -58.59540 1.000 88.70025  ? 134 ARG B CZ  1 
ATOM   3033 N  NH1 . ARG B 1 136 ? -32.36638 64.85704 -58.01762 1.000 74.42551  ? 134 ARG B NH1 1 
ATOM   3034 N  NH2 . ARG B 1 136 ? -30.72274 66.01151 -59.12149 1.000 93.13023  ? 134 ARG B NH2 1 
ATOM   3035 N  N   . ASN B 1 137 ? -29.89402 59.08717 -62.33703 1.000 42.19259  ? 135 ASN B N   1 
ATOM   3036 C  CA  . ASN B 1 137 ? -29.20766 58.88349 -63.60387 1.000 50.49876  ? 135 ASN B CA  1 
ATOM   3037 C  C   . ASN B 1 137 ? -29.87800 57.80831 -64.44170 1.000 48.97242  ? 135 ASN B C   1 
ATOM   3038 O  O   . ASN B 1 137 ? -29.86453 57.88608 -65.67343 1.000 48.20396  ? 135 ASN B O   1 
ATOM   3039 C  CB  . ASN B 1 137 ? -27.74319 58.54476 -63.35064 1.000 46.24372  ? 135 ASN B CB  1 
ATOM   3040 C  CG  . ASN B 1 137 ? -26.97629 59.72349 -62.80475 1.000 59.89414  ? 135 ASN B CG  1 
ATOM   3041 O  OD1 . ASN B 1 137 ? -26.99763 60.80476 -63.39232 1.000 65.58179  ? 135 ASN B OD1 1 
ATOM   3042 N  ND2 . ASN B 1 137 ? -26.31186 59.53593 -61.66758 1.000 57.61789  ? 135 ASN B ND2 1 
ATOM   3043 N  N   . LEU B 1 138 ? -30.46610 56.80634 -63.79636 1.000 42.28170  ? 136 LEU B N   1 
ATOM   3044 C  CA  . LEU B 1 138 ? -31.19091 55.78707 -64.53204 1.000 43.16608  ? 136 LEU B CA  1 
ATOM   3045 C  C   . LEU B 1 138 ? -32.43878 56.38504 -65.16506 1.000 48.64453  ? 136 LEU B C   1 
ATOM   3046 O  O   . LEU B 1 138 ? -32.81419 56.02945 -66.29112 1.000 46.70547  ? 136 LEU B O   1 
ATOM   3047 C  CB  . LEU B 1 138 ? -31.51093 54.63752 -63.57577 1.000 51.62336  ? 136 LEU B CB  1 
ATOM   3048 C  CG  . LEU B 1 138 ? -32.50459 53.55788 -63.95746 1.000 55.38127  ? 136 LEU B CG  1 
ATOM   3049 C  CD1 . LEU B 1 138 ? -32.03932 52.86354 -65.22235 1.000 66.46531  ? 136 LEU B CD1 1 
ATOM   3050 C  CD2 . LEU B 1 138 ? -32.60034 52.56909 -62.80784 1.000 53.80481  ? 136 LEU B CD2 1 
ATOM   3051 N  N   . ARG B 1 139 ? -33.05038 57.34790 -64.47395 1.000 51.27838  ? 137 ARG B N   1 
ATOM   3052 C  CA  A ARG B 1 139 ? -34.21679 58.05093 -65.00624 0.470 50.78820  ? 137 ARG B CA  1 
ATOM   3053 C  CA  B ARG B 1 139 ? -34.21552 58.03484 -65.01396 0.530 50.78443  ? 137 ARG B CA  1 
ATOM   3054 C  C   . ARG B 1 139 ? -33.84146 58.90562 -66.21468 1.000 52.68047  ? 137 ARG B C   1 
ATOM   3055 O  O   . ARG B 1 139 ? -34.55412 58.91241 -67.22653 1.000 51.59595  ? 137 ARG B O   1 
ATOM   3056 C  CB  A ARG B 1 139 ? -34.84095 58.90375 -63.89557 0.470 51.36447  ? 137 ARG B CB  1 
ATOM   3057 C  CB  B ARG B 1 139 ? -34.85921 58.85604 -63.90124 0.530 51.34932  ? 137 ARG B CB  1 
ATOM   3058 C  CG  A ARG B 1 139 ? -36.15989 59.60131 -64.22310 0.470 59.11128  ? 137 ARG B CG  1 
ATOM   3059 C  CG  B ARG B 1 139 ? -36.34324 59.00895 -64.01521 0.530 60.04451  ? 137 ARG B CG  1 
ATOM   3060 C  CD  A ARG B 1 139 ? -36.53508 60.62975 -63.12925 0.470 55.04126  ? 137 ARG B CD  1 
ATOM   3061 C  CD  B ARG B 1 139 ? -37.12124 58.01116 -63.16415 0.530 56.99872  ? 137 ARG B CD  1 
ATOM   3062 N  NE  A ARG B 1 139 ? -37.97745 60.70681 -62.91556 0.470 49.97950  ? 137 ARG B NE  1 
ATOM   3063 N  NE  B ARG B 1 139 ? -38.46782 57.90773 -63.71276 0.530 61.24171  ? 137 ARG B NE  1 
ATOM   3064 C  CZ  A ARG B 1 139 ? -38.72760 61.76358 -63.20222 0.470 58.00877  ? 137 ARG B CZ  1 
ATOM   3065 C  CZ  B ARG B 1 139 ? -38.98334 56.81419 -64.25181 0.530 56.11667  ? 137 ARG B CZ  1 
ATOM   3066 N  NH1 A ARG B 1 139 ? -38.20707 62.86075 -63.72871 0.470 60.41326  ? 137 ARG B NH1 1 
ATOM   3067 N  NH1 B ARG B 1 139 ? -38.34812 55.65436 -64.20920 0.530 60.60945  ? 137 ARG B NH1 1 
ATOM   3068 N  NH2 A ARG B 1 139 ? -40.03344 61.72066 -62.95092 0.470 56.91104  ? 137 ARG B NH2 1 
ATOM   3069 N  NH2 B ARG B 1 139 ? -40.16670 56.88624 -64.84391 0.530 56.43995  ? 137 ARG B NH2 1 
ATOM   3070 N  N   . ARG B 1 140 ? -32.71570 59.62907 -66.12941 1.000 49.28393  ? 138 ARG B N   1 
ATOM   3071 C  CA  . ARG B 1 140 ? -32.23883 60.45203 -67.24210 1.000 49.38525  ? 138 ARG B CA  1 
ATOM   3072 C  C   . ARG B 1 140 ? -31.95143 59.61642 -68.48010 1.000 50.88248  ? 138 ARG B C   1 
ATOM   3073 O  O   . ARG B 1 140 ? -32.39865 59.94228 -69.58185 1.000 57.74580  ? 138 ARG B O   1 
ATOM   3074 C  CB  . ARG B 1 140 ? -30.96376 61.19383 -66.85442 1.000 57.90146  ? 138 ARG B CB  1 
ATOM   3075 C  CG  . ARG B 1 140 ? -31.13983 62.61587 -66.40605 1.000 68.14669  ? 138 ARG B CG  1 
ATOM   3076 C  CD  . ARG B 1 140 ? -29.82168 63.39260 -66.57753 1.000 79.26473  ? 138 ARG B CD  1 
ATOM   3077 N  NE  . ARG B 1 140 ? -28.95880 63.28807 -65.40823 1.000 73.58310  ? 138 ARG B NE  1 
ATOM   3078 C  CZ  . ARG B 1 140 ? -29.30212 63.68585 -64.18787 1.000 89.24920  ? 138 ARG B CZ  1 
ATOM   3079 N  NH1 . ARG B 1 140 ? -30.46778 64.27019 -63.94988 1.000 85.56953  ? 138 ARG B NH1 1 
ATOM   3080 N  NH2 . ARG B 1 140 ? -28.45476 63.49344 -63.17669 1.000 88.47670  ? 138 ARG B NH2 1 
ATOM   3081 N  N   . VAL B 1 141 ? -31.16405 58.55293 -68.32284 1.000 47.69212  ? 139 VAL B N   1 
ATOM   3082 C  CA  . VAL B 1 141 ? -30.69731 57.78490 -69.46609 1.000 45.33171  ? 139 VAL B CA  1 
ATOM   3083 C  C   . VAL B 1 141 ? -31.80580 57.00037 -70.14076 1.000 45.35663  ? 139 VAL B C   1 
ATOM   3084 O  O   . VAL B 1 141 ? -31.61515 56.53453 -71.26759 1.000 45.82831  ? 139 VAL B O   1 
ATOM   3085 C  CB  . VAL B 1 141 ? -29.56855 56.83445 -69.02216 1.000 46.61828  ? 139 VAL B CB  1 
ATOM   3086 C  CG1 . VAL B 1 141 ? -30.16170 55.60763 -68.33984 1.000 37.96813  ? 139 VAL B CG1 1 
ATOM   3087 C  CG2 . VAL B 1 141 ? -28.68386 56.45326 -70.21806 1.000 41.11137  ? 139 VAL B CG2 1 
ATOM   3088 N  N   . ALA B 1 142 ? -32.96207 56.85498 -69.49021 1.000 40.46078  ? 140 ALA B N   1 
ATOM   3089 C  CA  . ALA B 1 142 ? -34.03946 56.05340 -70.06494 1.000 44.59673  ? 140 ALA B CA  1 
ATOM   3090 C  C   . ALA B 1 142 ? -34.58259 56.68274 -71.34012 1.000 45.08446  ? 140 ALA B C   1 
ATOM   3091 O  O   . ALA B 1 142 ? -34.98895 55.96669 -72.26150 1.000 45.90047  ? 140 ALA B O   1 
ATOM   3092 C  CB  . ALA B 1 142 ? -35.17790 55.87155 -69.05232 1.000 45.29386  ? 140 ALA B CB  1 
ATOM   3093 N  N   . ARG B 1 143 ? -34.65520 58.02002 -71.38869 1.000 49.24439  ? 141 ARG B N   1 
ATOM   3094 C  CA  A ARG B 1 143 ? -35.15703 58.67417 -72.59736 0.510 48.57583  ? 141 ARG B CA  1 
ATOM   3095 C  CA  B ARG B 1 143 ? -35.15842 58.67538 -72.59359 0.490 48.56968  ? 141 ARG B CA  1 
ATOM   3096 C  C   . ARG B 1 143 ? -34.21480 58.45829 -73.77524 1.000 49.69917  ? 141 ARG B C   1 
ATOM   3097 O  O   . ARG B 1 143 ? -34.67824 57.98305 -74.82815 1.000 47.69871  ? 141 ARG B O   1 
ATOM   3098 C  CB  A ARG B 1 143 ? -35.41717 60.16311 -72.33323 0.510 50.50527  ? 141 ARG B CB  1 
ATOM   3099 C  CB  B ARG B 1 143 ? -35.42747 60.15684 -72.29739 0.490 50.51090  ? 141 ARG B CB  1 
ATOM   3100 C  CG  A ARG B 1 143 ? -36.62544 60.47039 -71.43871 0.510 57.58868  ? 141 ARG B CG  1 
ATOM   3101 C  CG  B ARG B 1 143 ? -36.65219 60.41417 -71.38256 0.490 57.58291  ? 141 ARG B CG  1 
ATOM   3102 C  CD  A ARG B 1 143 ? -37.95528 60.06278 -72.08221 0.510 55.02714  ? 141 ARG B CD  1 
ATOM   3103 C  CD  B ARG B 1 143 ? -36.31678 60.43128 -69.87617 0.490 51.60777  ? 141 ARG B CD  1 
ATOM   3104 N  NE  A ARG B 1 143 ? -38.29465 58.67530 -71.77833 0.510 57.92554  ? 141 ARG B NE  1 
ATOM   3105 N  NE  B ARG B 1 143 ? -36.76771 59.21954 -69.18799 0.490 63.52978  ? 141 ARG B NE  1 
ATOM   3106 C  CZ  A ARG B 1 143 ? -39.01915 57.88856 -72.56280 0.510 54.30495  ? 141 ARG B CZ  1 
ATOM   3107 C  CZ  B ARG B 1 143 ? -37.97411 59.03750 -68.65695 0.490 62.47199  ? 141 ARG B CZ  1 
ATOM   3108 N  NH1 A ARG B 1 143 ? -39.52548 58.32540 -73.70341 0.510 45.63933  ? 141 ARG B NH1 1 
ATOM   3109 N  NH1 B ARG B 1 143 ? -38.89972 59.98555 -68.68957 0.490 67.78144  ? 141 ARG B NH1 1 
ATOM   3110 N  NH2 A ARG B 1 143 ? -39.24555 56.63337 -72.18978 0.510 55.37038  ? 141 ARG B NH2 1 
ATOM   3111 N  NH2 B ARG B 1 143 ? -38.26230 57.87068 -68.08598 0.490 52.13797  ? 141 ARG B NH2 1 
ATOM   3112 N  N   . PRO B 1 144 ? -32.90165 58.74630 -73.67543 1.000 47.41707  ? 142 PRO B N   1 
ATOM   3113 C  CA  . PRO B 1 144 ? -32.01246 58.39913 -74.79457 1.000 43.27052  ? 142 PRO B CA  1 
ATOM   3114 C  C   . PRO B 1 144 ? -32.08516 56.93442 -75.17230 1.000 50.73137  ? 142 PRO B C   1 
ATOM   3115 O  O   . PRO B 1 144 ? -31.98683 56.60348 -76.36211 1.000 51.16390  ? 142 PRO B O   1 
ATOM   3116 C  CB  . PRO B 1 144 ? -30.61579 58.74999 -74.26122 1.000 40.04810  ? 142 PRO B CB  1 
ATOM   3117 C  CG  . PRO B 1 144 ? -30.81975 59.64309 -73.16883 1.000 46.74885  ? 142 PRO B CG  1 
ATOM   3118 C  CD  . PRO B 1 144 ? -32.14950 59.38643 -72.58199 1.000 46.23701  ? 142 PRO B CD  1 
ATOM   3119 N  N   . VAL B 1 145 ? -32.21601 56.04005 -74.18207 1.000 46.98151  ? 143 VAL B N   1 
ATOM   3120 C  CA  . VAL B 1 145 ? -32.26752 54.61106 -74.48340 1.000 49.15428  ? 143 VAL B CA  1 
ATOM   3121 C  C   . VAL B 1 145 ? -33.47481 54.30918 -75.35427 1.000 47.60103  ? 143 VAL B C   1 
ATOM   3122 O  O   . VAL B 1 145 ? -33.36985 53.62219 -76.38125 1.000 44.88770  ? 143 VAL B O   1 
ATOM   3123 C  CB  . VAL B 1 145 ? -32.29353 53.77138 -73.19167 1.000 40.92726  ? 143 VAL B CB  1 
ATOM   3124 C  CG1 . VAL B 1 145 ? -32.64468 52.32322 -73.51697 1.000 37.73453  ? 143 VAL B CG1 1 
ATOM   3125 C  CG2 . VAL B 1 145 ? -30.95624 53.81350 -72.51254 1.000 45.63952  ? 143 VAL B CG2 1 
ATOM   3126 N  N   . TRP B 1 146 ? -34.64192 54.81633 -74.95013 1.000 42.31530  ? 144 TRP B N   1 
ATOM   3127 C  CA  . TRP B 1 146 ? -35.84995 54.57485 -75.72226 1.000 44.72100  ? 144 TRP B CA  1 
ATOM   3128 C  C   . TRP B 1 146 ? -35.75268 55.19634 -77.12044 1.000 49.59571  ? 144 TRP B C   1 
ATOM   3129 O  O   . TRP B 1 146 ? -36.14527 54.57162 -78.11542 1.000 44.00548  ? 144 TRP B O   1 
ATOM   3130 C  CB  . TRP B 1 146 ? -37.07779 55.11996 -74.99052 1.000 46.02792  ? 144 TRP B CB  1 
ATOM   3131 C  CG  . TRP B 1 146 ? -38.22772 54.98742 -75.91161 1.000 54.56663  ? 144 TRP B CG  1 
ATOM   3132 C  CD1 . TRP B 1 146 ? -38.83176 55.97654 -76.63403 1.000 46.07947  ? 144 TRP B CD1 1 
ATOM   3133 C  CD2 . TRP B 1 146 ? -38.84550 53.76099 -76.30967 1.000 46.28712  ? 144 TRP B CD2 1 
ATOM   3134 N  NE1 . TRP B 1 146 ? -39.80864 55.43877 -77.42549 1.000 48.14067  ? 144 TRP B NE1 1 
ATOM   3135 C  CE2 . TRP B 1 146 ? -39.83352 54.08017 -77.24640 1.000 44.96661  ? 144 TRP B CE2 1 
ATOM   3136 C  CE3 . TRP B 1 146 ? -38.67831 52.42701 -75.93142 1.000 46.78251  ? 144 TRP B CE3 1 
ATOM   3137 C  CZ2 . TRP B 1 146 ? -40.64718 53.11488 -77.82221 1.000 50.86358  ? 144 TRP B CZ2 1 
ATOM   3138 C  CZ3 . TRP B 1 146 ? -39.49018 51.47436 -76.49339 1.000 49.16131  ? 144 TRP B CZ3 1 
ATOM   3139 C  CH2 . TRP B 1 146 ? -40.46427 51.82171 -77.43040 1.000 46.62250  ? 144 TRP B CH2 1 
ATOM   3140 N  N   . LYS B 1 147 ? -35.24553 56.43084 -77.21060 1.000 46.06067  ? 145 LYS B N   1 
ATOM   3141 C  CA  . LYS B 1 147 ? -35.05430 57.07887 -78.50512 1.000 47.57773  ? 145 LYS B CA  1 
ATOM   3142 C  C   . LYS B 1 147 ? -34.22004 56.21114 -79.44170 1.000 53.09860  ? 145 LYS B C   1 
ATOM   3143 O  O   . LYS B 1 147 ? -34.57456 56.01990 -80.61349 1.000 49.60143  ? 145 LYS B O   1 
ATOM   3144 C  CB  . LYS B 1 147 ? -34.39437 58.44658 -78.31378 1.000 50.88024  ? 145 LYS B CB  1 
ATOM   3145 C  CG  . LYS B 1 147 ? -35.11423 59.59723 -78.97801 1.000 66.64467  ? 145 LYS B CG  1 
ATOM   3146 C  CD  . LYS B 1 147 ? -36.51836 59.78586 -78.39963 1.000 79.51120  ? 145 LYS B CD  1 
ATOM   3147 C  CE  . LYS B 1 147 ? -37.46551 60.40267 -79.43545 1.000 87.52247  ? 145 LYS B CE  1 
ATOM   3148 N  NZ  . LYS B 1 147 ? -38.89092 60.22077 -79.05380 1.000 88.22691  ? 145 LYS B NZ  1 
ATOM   3149 N  N   . ALA B 1 148 ? -33.10576 55.66934 -78.93534 1.000 46.01609  ? 146 ALA B N   1 
ATOM   3150 C  CA  . ALA B 1 148 ? -32.24491 54.83673 -79.77083 1.000 45.56621  ? 146 ALA B CA  1 
ATOM   3151 C  C   . ALA B 1 148 ? -32.97510 53.58821 -80.25298 1.000 46.30919  ? 146 ALA B C   1 
ATOM   3152 O  O   . ALA B 1 148 ? -32.81603 53.17786 -81.40578 1.000 48.02095  ? 146 ALA B O   1 
ATOM   3153 C  CB  . ALA B 1 148 ? -30.97167 54.45529 -79.01170 1.000 43.48085  ? 146 ALA B CB  1 
ATOM   3154 N  N   . TYR B 1 149 ? -33.78006 52.96354 -79.38994 1.000 45.98162  ? 147 TYR B N   1 
ATOM   3155 C  CA  . TYR B 1 149 ? -34.52429 51.79197 -79.84062 1.000 42.42040  ? 147 TYR B CA  1 
ATOM   3156 C  C   . TYR B 1 149 ? -35.57744 52.17654 -80.87401 1.000 46.76554  ? 147 TYR B C   1 
ATOM   3157 O  O   . TYR B 1 149 ? -35.72805 51.49802 -81.89937 1.000 47.51664  ? 147 TYR B O   1 
ATOM   3158 C  CB  . TYR B 1 149 ? -35.18552 51.07607 -78.65971 1.000 39.64876  ? 147 TYR B CB  1 
ATOM   3159 C  CG  . TYR B 1 149 ? -35.97688 49.88993 -79.11980 1.000 33.88816  ? 147 TYR B CG  1 
ATOM   3160 C  CD1 . TYR B 1 149 ? -35.33625 48.79596 -79.67523 1.000 33.94910  ? 147 TYR B CD1 1 
ATOM   3161 C  CD2 . TYR B 1 149 ? -37.36245 49.87143 -79.04481 1.000 35.80611  ? 147 TYR B CD2 1 
ATOM   3162 C  CE1 . TYR B 1 149 ? -36.04224 47.69331 -80.11682 1.000 33.39218  ? 147 TYR B CE1 1 
ATOM   3163 C  CE2 . TYR B 1 149 ? -38.08630 48.77134 -79.50251 1.000 37.03564  ? 147 TYR B CE2 1 
ATOM   3164 C  CZ  . TYR B 1 149 ? -37.41036 47.68739 -80.04019 1.000 37.06363  ? 147 TYR B CZ  1 
ATOM   3165 O  OH  . TYR B 1 149 ? -38.07970 46.57873 -80.50409 1.000 34.13464  ? 147 TYR B OH  1 
ATOM   3166 N  N   . GLU B 1 150 ? -36.32253 53.25514 -80.60459 1.000 46.08620  ? 148 GLU B N   1 
ATOM   3167 C  CA  . GLU B 1 150 ? -37.37740 53.71351 -81.50645 1.000 49.82786  ? 148 GLU B CA  1 
ATOM   3168 C  C   . GLU B 1 150 ? -36.82183 54.03494 -82.89286 1.000 52.25658  ? 148 GLU B C   1 
ATOM   3169 O  O   . GLU B 1 150 ? -37.36899 53.58994 -83.90884 1.000 50.92667  ? 148 GLU B O   1 
ATOM   3170 C  CB  . GLU B 1 150 ? -38.06795 54.92705 -80.88202 1.000 52.51044  ? 148 GLU B CB  1 
ATOM   3171 C  CG  . GLU B 1 150 ? -38.92212 55.79948 -81.76502 1.000 61.51309  ? 148 GLU B CG  1 
ATOM   3172 C  CD  . GLU B 1 150 ? -39.00100 57.22756 -81.21025 1.000 83.51740  ? 148 GLU B CD  1 
ATOM   3173 O  OE1 . GLU B 1 150 ? -38.16450 58.07219 -81.61811 1.000 83.87386  ? 148 GLU B OE1 1 
ATOM   3174 O  OE2 . GLU B 1 150 ? -39.87035 57.49405 -80.33911 1.000 82.45837  ? 148 GLU B OE2 1 
ATOM   3175 N  N   . GLN B 1 151 ? -35.71366 54.77678 -82.95483 1.000 44.71790  ? 149 GLN B N   1 
ATOM   3176 C  CA  . GLN B 1 151 ? -35.11127 55.08475 -84.25219 1.000 51.20347  ? 149 GLN B CA  1 
ATOM   3177 C  C   . GLN B 1 151 ? -34.66447 53.82211 -84.97802 1.000 50.14398  ? 149 GLN B C   1 
ATOM   3178 O  O   . GLN B 1 151 ? -34.78825 53.73175 -86.20390 1.000 54.54647  ? 149 GLN B O   1 
ATOM   3179 C  CB  . GLN B 1 151 ? -33.94239 56.05792 -84.08549 1.000 39.95930  ? 149 GLN B CB  1 
ATOM   3180 C  CG  . GLN B 1 151 ? -34.39959 57.43767 -83.62713 1.000 46.54847  ? 149 GLN B CG  1 
ATOM   3181 C  CD  . GLN B 1 151 ? -33.26672 58.27914 -83.03621 1.000 72.91832  ? 149 GLN B CD  1 
ATOM   3182 O  OE1 . GLN B 1 151 ? -33.33601 59.51069 -83.03619 1.000 81.18683  ? 149 GLN B OE1 1 
ATOM   3183 N  NE2 . GLN B 1 151 ? -32.20955 57.61744 -82.54442 1.000 68.42754  ? 149 GLN B NE2 1 
ATOM   3184 N  N   . ALA B 1 152 ? -34.15780 52.82793 -84.24338 1.000 52.86903  ? 150 ALA B N   1 
ATOM   3185 C  CA  . ALA B 1 152 ? -33.75250 51.58601 -84.89330 1.000 43.81036  ? 150 ALA B CA  1 
ATOM   3186 C  C   . ALA B 1 152 ? -34.94724 50.89370 -85.51789 1.000 48.39075  ? 150 ALA B C   1 
ATOM   3187 O  O   . ALA B 1 152 ? -34.85313 50.35621 -86.62771 1.000 53.08162  ? 150 ALA B O   1 
ATOM   3188 C  CB  . ALA B 1 152 ? -33.05513 50.66095 -83.89777 1.000 45.35543  ? 150 ALA B CB  1 
ATOM   3189 N  N   . VAL B 1 153 ? -36.08675 50.90686 -84.82640 1.000 43.38439  ? 151 VAL B N   1 
ATOM   3190 C  CA  . VAL B 1 153 ? -37.29505 50.32117 -85.39465 1.000 48.99561  ? 151 VAL B CA  1 
ATOM   3191 C  C   . VAL B 1 153 ? -37.76243 51.11695 -86.62368 1.000 49.87201  ? 151 VAL B C   1 
ATOM   3192 O  O   . VAL B 1 153 ? -38.19022 50.53532 -87.62500 1.000 51.50706  ? 151 VAL B O   1 
ATOM   3193 C  CB  . VAL B 1 153 ? -38.37539 50.21359 -84.29898 1.000 51.27717  ? 151 VAL B CB  1 
ATOM   3194 C  CG1 . VAL B 1 153 ? -39.70017 49.76813 -84.86960 1.000 43.28383  ? 151 VAL B CG1 1 
ATOM   3195 C  CG2 . VAL B 1 153 ? -37.92084 49.20880 -83.21129 1.000 49.76124  ? 151 VAL B CG2 1 
ATOM   3196 N  N   . GLU B 1 154 ? -37.66532 52.44831 -86.57411 1.000 47.88265  ? 152 GLU B N   1 
ATOM   3197 C  CA  . GLU B 1 154 ? -37.96668 53.28717 -87.73128 1.000 53.11843  ? 152 GLU B CA  1 
ATOM   3198 C  C   . GLU B 1 154 ? -37.09460 52.91962 -88.92837 1.000 57.82055  ? 152 GLU B C   1 
ATOM   3199 O  O   . GLU B 1 154 ? -37.60216 52.64434 -90.02233 1.000 49.18551  ? 152 GLU B O   1 
ATOM   3200 C  CB  . GLU B 1 154 ? -37.73590 54.75249 -87.38555 1.000 58.06771  ? 152 GLU B CB  1 
ATOM   3201 C  CG  . GLU B 1 154 ? -38.95674 55.57397 -87.14838 1.000 66.53177  ? 152 GLU B CG  1 
ATOM   3202 C  CD  . GLU B 1 154 ? -38.72254 56.67062 -86.09266 1.000 91.08265  ? 152 GLU B CD  1 
ATOM   3203 O  OE1 . GLU B 1 154 ? -37.59395 57.21839 -85.94691 1.000 84.32490  ? 152 GLU B OE1 1 
ATOM   3204 O  OE2 . GLU B 1 154 ? -39.68388 56.95295 -85.36663 1.000 93.08850  ? 152 GLU B OE2 1 
ATOM   3205 N  N   . ARG B 1 155 ? -35.76875 52.92717 -88.74044 1.000 51.41877  ? 153 ARG B N   1 
ATOM   3206 C  CA  . ARG B 1 155 ? -34.87254 52.64790 -89.85604 1.000 53.02690  ? 153 ARG B CA  1 
ATOM   3207 C  C   . ARG B 1 155 ? -35.20051 51.31200 -90.51310 1.000 42.60029  ? 153 ARG B C   1 
ATOM   3208 O  O   . ARG B 1 155 ? -35.12439 51.18340 -91.73676 1.000 59.01498  ? 153 ARG B O   1 
ATOM   3209 C  CB  . ARG B 1 155 ? -33.41490 52.70356 -89.39332 1.000 39.89306  ? 153 ARG B CB  1 
ATOM   3210 C  CG  . ARG B 1 155 ? -32.99690 54.10192 -88.99331 1.000 45.28574  ? 153 ARG B CG  1 
ATOM   3211 C  CD  . ARG B 1 155 ? -31.48580 54.20056 -88.82309 1.000 47.64454  ? 153 ARG B CD  1 
ATOM   3212 N  NE  . ARG B 1 155 ? -30.97746 53.15785 -87.94138 1.000 56.37489  ? 153 ARG B NE  1 
ATOM   3213 C  CZ  . ARG B 1 155 ? -30.81618 53.29629 -86.62935 1.000 49.60856  ? 153 ARG B CZ  1 
ATOM   3214 N  NH1 . ARG B 1 155 ? -31.09340 54.43371 -86.01134 1.000 51.82311  ? 153 ARG B NH1 1 
ATOM   3215 N  NH2 . ARG B 1 155 ? -30.35257 52.27244 -85.92191 1.000 49.19983  ? 153 ARG B NH2 1 
ATOM   3216 N  N   . ALA B 1 156 ? -35.60469 50.32369 -89.73258 1.000 49.17598  ? 154 ALA B N   1 
ATOM   3217 C  CA  . ALA B 1 156 ? -35.95450 49.02266 -90.28907 1.000 45.42737  ? 154 ALA B CA  1 
ATOM   3218 C  C   . ALA B 1 156 ? -37.33745 49.00700 -90.93402 1.000 51.33922  ? 154 ALA B C   1 
ATOM   3219 O  O   . ALA B 1 156 ? -37.73897 47.97099 -91.47828 1.000 43.67670  ? 154 ALA B O   1 
ATOM   3220 C  CB  . ALA B 1 156 ? -35.87157 47.95135 -89.19567 1.000 37.74561  ? 154 ALA B CB  1 
ATOM   3221 N  N   . GLY B 1 157 ? -38.07894 50.11355 -90.87685 1.000 46.24514  ? 155 GLY B N   1 
ATOM   3222 C  CA  . GLY B 1 157 ? -39.42489 50.13581 -91.42003 1.000 42.15774  ? 155 GLY B CA  1 
ATOM   3223 C  C   . GLY B 1 157 ? -40.44128 49.26375 -90.70718 1.000 57.06037  ? 155 GLY B C   1 
ATOM   3224 O  O   . GLY B 1 157 ? -41.35829 48.73976 -91.35408 1.000 56.42730  ? 155 GLY B O   1 
ATOM   3225 N  N   . LEU B 1 158 ? -40.32073 49.09829 -89.38949 1.000 56.20656  ? 156 LEU B N   1 
ATOM   3226 C  CA  . LEU B 1 158 ? -41.20509 48.22115 -88.63341 1.000 50.73353  ? 156 LEU B CA  1 
ATOM   3227 C  C   . LEU B 1 158 ? -42.07993 49.03572 -87.69433 1.000 44.67415  ? 156 LEU B C   1 
ATOM   3228 O  O   . LEU B 1 158 ? -41.73802 50.15433 -87.30840 1.000 53.19764  ? 156 LEU B O   1 
ATOM   3229 C  CB  . LEU B 1 158 ? -40.40937 47.20421 -87.81517 1.000 51.10435  ? 156 LEU B CB  1 
ATOM   3230 C  CG  . LEU B 1 158 ? -39.45592 46.29217 -88.57825 1.000 55.89490  ? 156 LEU B CG  1 
ATOM   3231 C  CD1 . LEU B 1 158 ? -38.50742 45.61720 -87.57991 1.000 50.54325  ? 156 LEU B CD1 1 
ATOM   3232 C  CD2 . LEU B 1 158 ? -40.24834 45.27573 -89.37187 1.000 49.41379  ? 156 LEU B CD2 1 
ATOM   3233 N  N   . SER B 1 159 ? -43.21832 48.46356 -87.33067 1.000 45.34111  ? 157 SER B N   1 
ATOM   3234 C  CA  . SER B 1 159 ? -44.03701 49.00157 -86.25277 1.000 49.78495  ? 157 SER B CA  1 
ATOM   3235 C  C   . SER B 1 159 ? -43.80882 48.21179 -84.96829 1.000 48.95244  ? 157 SER B C   1 
ATOM   3236 O  O   . SER B 1 159 ? -43.45444 47.02906 -84.99776 1.000 47.38757  ? 157 SER B O   1 
ATOM   3237 C  CB  . SER B 1 159 ? -45.52377 48.96052 -86.60446 1.000 46.19694  ? 157 SER B CB  1 
ATOM   3238 O  OG  . SER B 1 159 ? -45.98476 47.62561 -86.64381 1.000 53.31273  ? 157 SER B OG  1 
ATOM   3239 N  N   . LEU B 1 160 ? -44.04978 48.87029 -83.83444 1.000 45.35372  ? 158 LEU B N   1 
ATOM   3240 C  CA  . LEU B 1 160 ? -43.98585 48.16902 -82.55957 1.000 45.94701  ? 158 LEU B CA  1 
ATOM   3241 C  C   . LEU B 1 160 ? -44.92199 46.96515 -82.53490 1.000 45.84476  ? 158 LEU B C   1 
ATOM   3242 O  O   . LEU B 1 160 ? -44.57805 45.92825 -81.96208 1.000 48.97122  ? 158 LEU B O   1 
ATOM   3243 C  CB  . LEU B 1 160 ? -44.31219 49.12544 -81.41553 1.000 46.30789  ? 158 LEU B CB  1 
ATOM   3244 C  CG  . LEU B 1 160 ? -43.08650 49.82232 -80.83736 1.000 50.86726  ? 158 LEU B CG  1 
ATOM   3245 C  CD1 . LEU B 1 160 ? -43.50746 50.82856 -79.77025 1.000 48.44499  ? 158 LEU B CD1 1 
ATOM   3246 C  CD2 . LEU B 1 160 ? -42.11398 48.79180 -80.28830 1.000 55.97389  ? 158 LEU B CD2 1 
ATOM   3247 N  N   . GLN B 1 161 ? -46.11287 47.07559 -83.14524 1.000 41.74019  ? 159 GLN B N   1 
ATOM   3248 C  CA  . GLN B 1 161 ? -47.03000 45.93392 -83.15774 1.000 39.83866  ? 159 GLN B CA  1 
ATOM   3249 C  C   . GLN B 1 161 ? -46.41786 44.73572 -83.86317 1.000 44.70725  ? 159 GLN B C   1 
ATOM   3250 O  O   . GLN B 1 161 ? -46.70580 43.59068 -83.49786 1.000 47.42923  ? 159 GLN B O   1 
ATOM   3251 C  CB  . GLN B 1 161 ? -48.35274 46.31343 -83.82474 1.000 46.04384  ? 159 GLN B CB  1 
ATOM   3252 C  CG  . GLN B 1 161 ? -49.20637 47.25244 -82.99653 1.000 47.29448  ? 159 GLN B CG  1 
ATOM   3253 C  CD  . GLN B 1 161 ? -49.47100 46.69146 -81.60828 1.000 49.36589  ? 159 GLN B CD  1 
ATOM   3254 O  OE1 . GLN B 1 161 ? -49.85147 45.52856 -81.46638 1.000 41.96270  ? 159 GLN B OE1 1 
ATOM   3255 N  NE2 . GLN B 1 161 ? -49.21736 47.50170 -80.57520 1.000 42.05331  ? 159 GLN B NE2 1 
ATOM   3256 N  N   . ASP B 1 162 ? -45.56897 44.99587 -84.86715 1.000 50.11974  ? 160 ASP B N   1 
ATOM   3257 C  CA  . ASP B 1 162 ? -44.83316 43.96921 -85.60877 1.000 45.91190  ? 160 ASP B CA  1 
ATOM   3258 C  C   . ASP B 1 162 ? -43.90866 43.16771 -84.71558 1.000 44.07488  ? 160 ASP B C   1 
ATOM   3259 O  O   . ASP B 1 162 ? -43.95977 41.92906 -84.69071 1.000 46.34310  ? 160 ASP B O   1 
ATOM   3260 C  CB  . ASP B 1 162 ? -43.97828 44.64648 -86.67078 1.000 65.79549  ? 160 ASP B CB  1 
ATOM   3261 C  CG  . ASP B 1 162 ? -44.57630 44.58221 -88.01375 1.000 72.32486  ? 160 ASP B CG  1 
ATOM   3262 O  OD1 . ASP B 1 162 ? -44.21039 45.47153 -88.82829 1.000 71.18471  ? 160 ASP B OD1 1 
ATOM   3263 O  OD2 . ASP B 1 162 ? -45.37793 43.63975 -88.24045 1.000 73.42532  ? 160 ASP B OD2 1 
ATOM   3264 N  N   . VAL B 1 163 ? -42.99360 43.86882 -84.03104 1.000 44.50663  ? 161 VAL B N   1 
ATOM   3265 C  CA  . VAL B 1 163 ? -42.02628 43.19502 -83.17317 1.000 44.97210  ? 161 VAL B CA  1 
ATOM   3266 C  C   . VAL B 1 163 ? -42.73587 42.46565 -82.03909 1.000 45.88673  ? 161 VAL B C   1 
ATOM   3267 O  O   . VAL B 1 163 ? -42.33981 41.35688 -81.66753 1.000 51.21062  ? 161 VAL B O   1 
ATOM   3268 C  CB  . VAL B 1 163 ? -40.96183 44.18918 -82.66736 1.000 50.96969  ? 161 VAL B CB  1 
ATOM   3269 C  CG1 . VAL B 1 163 ? -40.22419 44.79463 -83.85910 1.000 52.95186  ? 161 VAL B CG1 1 
ATOM   3270 C  CG2 . VAL B 1 163 ? -41.57597 45.29900 -81.88807 1.000 53.08985  ? 161 VAL B CG2 1 
ATOM   3271 N  N   . ILE B 1 164 ? -43.82582 43.03814 -81.50821 1.000 43.99689  ? 162 ILE B N   1 
ATOM   3272 C  CA  . ILE B 1 164 ? -44.59572 42.34019 -80.47507 1.000 45.33020  ? 162 ILE B CA  1 
ATOM   3273 C  C   . ILE B 1 164 ? -45.17880 41.04918 -81.03612 1.000 43.49950  ? 162 ILE B C   1 
ATOM   3274 O  O   . ILE B 1 164 ? -45.08635 39.98318 -80.41915 1.000 46.62301  ? 162 ILE B O   1 
ATOM   3275 C  CB  . ILE B 1 164 ? -45.70398 43.24925 -79.90155 1.000 44.71219  ? 162 ILE B CB  1 
ATOM   3276 C  CG1 . ILE B 1 164 ? -45.13506 44.33653 -79.01045 1.000 42.00492  ? 162 ILE B CG1 1 
ATOM   3277 C  CG2 . ILE B 1 164 ? -46.66120 42.46221 -79.06365 1.000 36.31383  ? 162 ILE B CG2 1 
ATOM   3278 C  CD1 . ILE B 1 164 ? -46.20249 45.28950 -78.52327 1.000 44.09335  ? 162 ILE B CD1 1 
ATOM   3279 N  N   . ALA B 1 165 ? -45.79375 41.12531 -82.21796 1.000 44.99981  ? 163 ALA B N   1 
ATOM   3280 C  CA  . ALA B 1 165 ? -46.43235 39.94271 -82.77885 1.000 43.41630  ? 163 ALA B CA  1 
ATOM   3281 C  C   . ALA B 1 165 ? -45.41115 38.86704 -83.13682 1.000 43.16930  ? 163 ALA B C   1 
ATOM   3282 O  O   . ALA B 1 165 ? -45.72525 37.67177 -83.09684 1.000 44.49880  ? 163 ALA B O   1 
ATOM   3283 C  CB  . ALA B 1 165 ? -47.25994 40.33025 -84.00716 1.000 42.18642  ? 163 ALA B CB  1 
ATOM   3284 N  N   . GLN B 1 166 ? -44.19089 39.26185 -83.49261 1.000 43.67480  ? 164 GLN B N   1 
ATOM   3285 C  CA  . GLN B 1 166 ? -43.19660 38.27918 -83.90874 1.000 42.53125  ? 164 GLN B CA  1 
ATOM   3286 C  C   . GLN B 1 166 ? -42.68348 37.43196 -82.75837 1.000 44.75092  ? 164 GLN B C   1 
ATOM   3287 O  O   . GLN B 1 166 ? -41.98988 36.43940 -82.99993 1.000 44.06797  ? 164 GLN B O   1 
ATOM   3288 C  CB  . GLN B 1 166 ? -42.03596 38.98115 -84.60916 1.000 42.16495  ? 164 GLN B CB  1 
ATOM   3289 C  CG  . GLN B 1 166 ? -42.32958 39.10049 -86.09795 1.000 50.42857  ? 164 GLN B CG  1 
ATOM   3290 C  CD  . GLN B 1 166 ? -41.32547 39.92219 -86.83797 1.000 50.69672  ? 164 GLN B CD  1 
ATOM   3291 O  OE1 . GLN B 1 166 ? -40.13508 39.64049 -86.79676 1.000 57.85642  ? 164 GLN B OE1 1 
ATOM   3292 N  NE2 . GLN B 1 166 ? -41.79884 40.93238 -87.55090 1.000 56.00928  ? 164 GLN B NE2 1 
ATOM   3293 N  N   . GLN B 1 167 ? -43.01433 37.77970 -81.51801 1.000 45.47978  ? 165 GLN B N   1 
ATOM   3294 C  CA  . GLN B 1 167 ? -42.62475 36.91872 -80.41643 1.000 46.32969  ? 165 GLN B CA  1 
ATOM   3295 C  C   . GLN B 1 167 ? -43.42648 35.62049 -80.38960 1.000 43.79038  ? 165 GLN B C   1 
ATOM   3296 O  O   . GLN B 1 167 ? -42.96742 34.63901 -79.79840 1.000 47.78438  ? 165 GLN B O   1 
ATOM   3297 C  CB  . GLN B 1 167 ? -42.76819 37.69313 -79.11356 1.000 45.46256  ? 165 GLN B CB  1 
ATOM   3298 C  CG  . GLN B 1 167 ? -42.07403 37.08559 -77.93827 1.000 41.90168  ? 165 GLN B CG  1 
ATOM   3299 C  CD  . GLN B 1 167 ? -42.60581 37.66103 -76.64212 1.000 48.43828  ? 165 GLN B CD  1 
ATOM   3300 O  OE1 . GLN B 1 167 ? -43.25540 38.71392 -76.63835 1.000 51.41497  ? 165 GLN B OE1 1 
ATOM   3301 N  NE2 . GLN B 1 167 ? -42.35182 36.97244 -75.54186 1.000 43.16060  ? 165 GLN B NE2 1 
ATOM   3302 N  N   . ASP B 1 168 ? -44.58419 35.58753 -81.05005 1.000 37.98717  ? 166 ASP B N   1 
ATOM   3303 C  CA  . ASP B 1 168 ? -45.48238 34.43674 -81.06934 1.000 42.39493  ? 166 ASP B CA  1 
ATOM   3304 C  C   . ASP B 1 168 ? -45.13397 33.52246 -82.24768 1.000 48.67552  ? 166 ASP B C   1 
ATOM   3305 O  O   . ASP B 1 168 ? -45.19023 33.94370 -83.41022 1.000 46.00951  ? 166 ASP B O   1 
ATOM   3306 C  CB  . ASP B 1 168 ? -46.93016 34.94312 -81.14588 1.000 41.90533  ? 166 ASP B CB  1 
ATOM   3307 C  CG  . ASP B 1 168 ? -47.97250 33.83482 -81.33863 1.000 45.00171  ? 166 ASP B CG  1 
ATOM   3308 O  OD1 . ASP B 1 168 ? -47.64398 32.63026 -81.43108 1.000 49.76353  ? 166 ASP B OD1 1 
ATOM   3309 O  OD2 . ASP B 1 168 ? -49.16712 34.18969 -81.38545 1.000 45.27452  ? 166 ASP B OD2 1 
ATOM   3310 N  N   . ASP B 1 169 ? -44.79943 32.26380 -81.94425 1.000 47.92832  ? 167 ASP B N   1 
ATOM   3311 C  CA  . ASP B 1 169 ? -44.45417 31.29991 -82.98887 1.000 46.31687  ? 167 ASP B CA  1 
ATOM   3312 C  C   . ASP B 1 169 ? -45.59807 31.06911 -83.96185 1.000 51.72839  ? 167 ASP B C   1 
ATOM   3313 O  O   . ASP B 1 169 ? -45.35694 30.76291 -85.13412 1.000 49.33110  ? 167 ASP B O   1 
ATOM   3314 C  CB  . ASP B 1 169 ? -44.06802 29.96581 -82.36872 1.000 49.27532  ? 167 ASP B CB  1 
ATOM   3315 C  CG  . ASP B 1 169 ? -42.65266 29.95238 -81.87027 1.000 54.72776  ? 167 ASP B CG  1 
ATOM   3316 O  OD1 . ASP B 1 169 ? -41.89529 30.90115 -82.20256 1.000 50.61222  ? 167 ASP B OD1 1 
ATOM   3317 O  OD2 . ASP B 1 169 ? -42.31576 28.99644 -81.13627 1.000 51.92282  ? 167 ASP B OD2 1 
ATOM   3318 N  N   . GLY B 1 170 ? -46.83980 31.16366 -83.49133 1.000 46.80677  ? 168 GLY B N   1 
ATOM   3319 C  CA  . GLY B 1 170 ? -47.98833 31.00706 -84.35338 1.000 48.34801  ? 168 GLY B CA  1 
ATOM   3320 C  C   . GLY B 1 170 ? -48.30406 32.18386 -85.25920 1.000 55.23606  ? 168 GLY B C   1 
ATOM   3321 O  O   . GLY B 1 170 ? -49.22308 32.09076 -86.07433 1.000 55.05719  ? 168 GLY B O   1 
ATOM   3322 N  N   . TYR B 1 171 ? -47.59522 33.30246 -85.13853 1.000 48.75050  ? 169 TYR B N   1 
ATOM   3323 C  CA  . TYR B 1 171 ? -47.87650 34.45286 -85.98188 1.000 52.29497  ? 169 TYR B CA  1 
ATOM   3324 C  C   . TYR B 1 171 ? -47.23928 34.25062 -87.35472 1.000 51.79092  ? 169 TYR B C   1 
ATOM   3325 O  O   . TYR B 1 171 ? -46.05506 33.91402 -87.45301 1.000 47.97003  ? 169 TYR B O   1 
ATOM   3326 C  CB  . TYR B 1 171 ? -47.36473 35.72538 -85.31562 1.000 46.22853  ? 169 TYR B CB  1 
ATOM   3327 C  CG  . TYR B 1 171 ? -47.32411 36.94747 -86.20367 1.000 45.12138  ? 169 TYR B CG  1 
ATOM   3328 C  CD1 . TYR B 1 171 ? -48.49656 37.58427 -86.60778 1.000 46.54988  ? 169 TYR B CD1 1 
ATOM   3329 C  CD2 . TYR B 1 171 ? -46.11405 37.48263 -86.60871 1.000 46.56461  ? 169 TYR B CD2 1 
ATOM   3330 C  CE1 . TYR B 1 171 ? -48.45772 38.71547 -87.40428 1.000 46.56474  ? 169 TYR B CE1 1 
ATOM   3331 C  CE2 . TYR B 1 171 ? -46.05568 38.59817 -87.40515 1.000 47.61195  ? 169 TYR B CE2 1 
ATOM   3332 C  CZ  . TYR B 1 171 ? -47.22854 39.21717 -87.80137 1.000 54.56860  ? 169 TYR B CZ  1 
ATOM   3333 O  OH  . TYR B 1 171 ? -47.16012 40.34406 -88.59123 1.000 53.17605  ? 169 TYR B OH  1 
ATOM   3334 N  N   . ASP B 1 172 ? -48.03045 34.47297 -88.41045 1.000 52.63977  ? 170 ASP B N   1 
ATOM   3335 C  CA  . ASP B 1 172 ? -47.72465 34.02985 -89.77203 1.000 59.51208  ? 170 ASP B CA  1 
ATOM   3336 C  C   . ASP B 1 172 ? -47.20239 35.12712 -90.69904 1.000 49.64938  ? 170 ASP B C   1 
ATOM   3337 O  O   . ASP B 1 172 ? -46.95231 34.84584 -91.87050 1.000 53.59075  ? 170 ASP B O   1 
ATOM   3338 C  CB  . ASP B 1 172 ? -48.97275 33.39148 -90.39550 1.000 51.50418  ? 170 ASP B CB  1 
ATOM   3339 C  CG  . ASP B 1 172 ? -50.11746 34.39161 -90.59156 1.000 67.65868  ? 170 ASP B CG  1 
ATOM   3340 O  OD1 . ASP B 1 172 ? -51.15225 34.00414 -91.17811 1.000 74.34150  ? 170 ASP B OD1 1 
ATOM   3341 O  OD2 . ASP B 1 172 ? -49.99405 35.56520 -90.17511 1.000 76.50712  ? 170 ASP B OD2 1 
ATOM   3342 N  N   . GLY B 1 173 ? -47.03963 36.35544 -90.21760 1.000 47.03848  ? 171 GLY B N   1 
ATOM   3343 C  CA  . GLY B 1 173 ? -46.59074 37.44674 -91.05609 1.000 52.17676  ? 171 GLY B CA  1 
ATOM   3344 C  C   . GLY B 1 173 ? -45.11415 37.36116 -91.36924 1.000 54.51694  ? 171 GLY B C   1 
ATOM   3345 O  O   . GLY B 1 173 ? -44.36195 36.54733 -90.81687 1.000 55.80789  ? 171 GLY B O   1 
ATOM   3346 N  N   . PRO B 1 174 ? -44.66885 38.22339 -92.27382 1.000 58.79187  ? 172 PRO B N   1 
ATOM   3347 C  CA  . PRO B 1 174 ? -43.28165 38.13991 -92.74352 1.000 49.20769  ? 172 PRO B CA  1 
ATOM   3348 C  C   . PRO B 1 174 ? -42.29792 38.59268 -91.67901 1.000 51.82475  ? 172 PRO B C   1 
ATOM   3349 O  O   . PRO B 1 174 ? -42.57231 39.49263 -90.87834 1.000 56.05751  ? 172 PRO B O   1 
ATOM   3350 C  CB  . PRO B 1 174 ? -43.25110 39.08365 -93.95581 1.000 51.66022  ? 172 PRO B CB  1 
ATOM   3351 C  CG  . PRO B 1 174 ? -44.69625 39.49711 -94.20829 1.000 48.15638  ? 172 PRO B CG  1 
ATOM   3352 C  CD  . PRO B 1 174 ? -45.40644 39.33704 -92.89657 1.000 59.65005  ? 172 PRO B CD  1 
ATOM   3353 N  N   . ARG B 1 175 ? -41.12832 37.96028 -91.69004 1.000 52.30679  ? 173 ARG B N   1 
ATOM   3354 C  CA  . ARG B 1 175 ? -40.04802 38.29113 -90.77516 1.000 52.32636  ? 173 ARG B CA  1 
ATOM   3355 C  C   . ARG B 1 175 ? -38.72912 38.35576 -91.52169 1.000 46.12672  ? 173 ARG B C   1 
ATOM   3356 O  O   . ARG B 1 175 ? -38.53264 37.67239 -92.52593 1.000 55.38307  ? 173 ARG B O   1 
ATOM   3357 C  CB  . ARG B 1 175 ? -39.90631 37.25834 -89.66304 1.000 48.19312  ? 173 ARG B CB  1 
ATOM   3358 C  CG  . ARG B 1 175 ? -41.19825 36.66777 -89.22899 1.000 50.04430  ? 173 ARG B CG  1 
ATOM   3359 C  CD  . ARG B 1 175 ? -40.97358 35.74216 -88.07276 1.000 56.51853  ? 173 ARG B CD  1 
ATOM   3360 N  NE  . ARG B 1 175 ? -42.23482 35.25013 -87.54584 1.000 57.24463  ? 173 ARG B NE  1 
ATOM   3361 C  CZ  . ARG B 1 175 ? -42.38249 34.73706 -86.33508 1.000 49.81174  ? 173 ARG B CZ  1 
ATOM   3362 N  NH1 . ARG B 1 175 ? -41.35745 34.62255 -85.50894 1.000 53.03703  ? 173 ARG B NH1 1 
ATOM   3363 N  NH2 . ARG B 1 175 ? -43.58749 34.31988 -85.95039 1.000 50.16109  ? 173 ARG B NH2 1 
ATOM   3364 N  N   . SER B 1 176 ? -37.81910 39.15702 -90.99335 1.000 49.07452  ? 174 SER B N   1 
ATOM   3365 C  CA  . SER B 1 176 ? -36.41152 39.14843 -91.35687 1.000 50.26943  ? 174 SER B CA  1 
ATOM   3366 C  C   . SER B 1 176 ? -35.57962 38.82073 -90.12210 1.000 51.14652  ? 174 SER B C   1 
ATOM   3367 O  O   . SER B 1 176 ? -36.07777 38.81920 -88.99073 1.000 49.48907  ? 174 SER B O   1 
ATOM   3368 C  CB  . SER B 1 176 ? -35.98805 40.50594 -91.91026 1.000 49.74249  ? 174 SER B CB  1 
ATOM   3369 O  OG  . SER B 1 176 ? -36.59589 41.53545 -91.14740 1.000 49.89237  ? 174 SER B OG  1 
ATOM   3370 N  N   . GLY B 1 177 ? -34.28991 38.56196 -90.34325 1.000 53.83188  ? 175 GLY B N   1 
ATOM   3371 C  CA  . GLY B 1 177 ? -33.37037 38.46376 -89.22103 1.000 39.15386  ? 175 GLY B CA  1 
ATOM   3372 C  C   . GLY B 1 177 ? -33.35146 39.74524 -88.41281 1.000 51.37135  ? 175 GLY B C   1 
ATOM   3373 O  O   . GLY B 1 177 ? -33.28012 39.71942 -87.18083 1.000 54.95637  ? 175 GLY B O   1 
ATOM   3374 N  N   . GLY B 1 178 ? -33.46675 40.88494 -89.09301 1.000 48.96889  ? 176 GLY B N   1 
ATOM   3375 C  CA  . GLY B 1 178 ? -33.46605 42.15684 -88.38868 1.000 41.26516  ? 176 GLY B CA  1 
ATOM   3376 C  C   . GLY B 1 178 ? -34.70854 42.37611 -87.54298 1.000 51.27784  ? 176 GLY B C   1 
ATOM   3377 O  O   . GLY B 1 178 ? -34.62226 42.93226 -86.44370 1.000 50.43743  ? 176 GLY B O   1 
ATOM   3378 N  N   . SER B 1 179 ? -35.88616 41.96541 -88.03885 1.000 43.49178  ? 177 SER B N   1 
ATOM   3379 C  CA  . SER B 1 179 ? -37.09634 42.23121 -87.26334 1.000 50.78735  ? 177 SER B CA  1 
ATOM   3380 C  C   . SER B 1 179 ? -37.15256 41.35098 -86.01171 1.000 53.87961  ? 177 SER B C   1 
ATOM   3381 O  O   . SER B 1 179 ? -37.52597 41.82666 -84.92906 1.000 47.78531  ? 177 SER B O   1 
ATOM   3382 C  CB  . SER B 1 179 ? -38.35191 42.06236 -88.12786 1.000 43.26481  ? 177 SER B CB  1 
ATOM   3383 O  OG  . SER B 1 179 ? -38.59496 40.71268 -88.47034 1.000 46.74055  ? 177 SER B OG  1 
ATOM   3384 N  N   . GLN B 1 180 ? -36.74235 40.08138 -86.12949 1.000 47.96453  ? 178 GLN B N   1 
ATOM   3385 C  CA  . GLN B 1 180 ? -36.69790 39.19538 -84.96967 1.000 44.38460  ? 178 GLN B CA  1 
ATOM   3386 C  C   . GLN B 1 180 ? -35.61410 39.60673 -83.97568 1.000 46.54234  ? 178 GLN B C   1 
ATOM   3387 O  O   . GLN B 1 180 ? -35.77737 39.40478 -82.76988 1.000 44.31960  ? 178 GLN B O   1 
ATOM   3388 C  CB  . GLN B 1 180 ? -36.50453 37.75400 -85.43485 1.000 40.46875  ? 178 GLN B CB  1 
ATOM   3389 C  CG  . GLN B 1 180 ? -37.54580 37.35382 -86.45407 1.000 43.06460  ? 178 GLN B CG  1 
ATOM   3390 C  CD  . GLN B 1 180 ? -37.75412 35.86229 -86.56391 1.000 51.34759  ? 178 GLN B CD  1 
ATOM   3391 O  OE1 . GLN B 1 180 ? -38.50330 35.26197 -85.78970 1.000 54.57862  ? 178 GLN B OE1 1 
ATOM   3392 N  NE2 . GLN B 1 180 ? -37.10611 35.25097 -87.55649 1.000 62.74749  ? 178 GLN B NE2 1 
ATOM   3393 N  N   . SER B 1 181 ? -34.50853 40.18683 -84.44476 1.000 46.77361  ? 179 SER B N   1 
ATOM   3394 C  CA  . SER B 1 181 ? -33.51844 40.70813 -83.50605 1.000 46.41149  ? 179 SER B CA  1 
ATOM   3395 C  C   . SER B 1 181 ? -34.09206 41.86581 -82.69848 1.000 47.17614  ? 179 SER B C   1 
ATOM   3396 O  O   . SER B 1 181 ? -33.87050 41.95977 -81.48351 1.000 41.60400  ? 179 SER B O   1 
ATOM   3397 C  CB  . SER B 1 181 ? -32.25551 41.15918 -84.24501 1.000 42.25800  ? 179 SER B CB  1 
ATOM   3398 O  OG  . SER B 1 181 ? -31.59222 40.04687 -84.81731 1.000 49.30564  ? 179 SER B OG  1 
ATOM   3399 N  N   . LEU B 1 182 ? -34.80879 42.77574 -83.36537 1.000 41.59199  ? 180 LEU B N   1 
ATOM   3400 C  CA  . LEU B 1 182 ? -35.40862 43.89456 -82.65878 1.000 39.91725  ? 180 LEU B CA  1 
ATOM   3401 C  C   . LEU B 1 182 ? -36.55360 43.43200 -81.76185 1.000 40.08167  ? 180 LEU B C   1 
ATOM   3402 O  O   . LEU B 1 182 ? -36.83695 44.07739 -80.75035 1.000 40.08984  ? 180 LEU B O   1 
ATOM   3403 C  CB  . LEU B 1 182 ? -35.87381 44.95684 -83.65957 1.000 46.28025  ? 180 LEU B CB  1 
ATOM   3404 C  CG  . LEU B 1 182 ? -34.72981 45.81701 -84.22030 1.000 48.13322  ? 180 LEU B CG  1 
ATOM   3405 C  CD1 . LEU B 1 182 ? -35.12668 46.51329 -85.51660 1.000 42.56338  ? 180 LEU B CD1 1 
ATOM   3406 C  CD2 . LEU B 1 182 ? -34.31799 46.83022 -83.19305 1.000 41.69099  ? 180 LEU B CD2 1 
ATOM   3407 N  N   . ALA B 1 183 ? -37.20875 42.32178 -82.11245 1.000 36.78400  ? 181 ALA B N   1 
ATOM   3408 C  CA  . ALA B 1 183 ? -38.13998 41.67122 -81.19775 1.000 38.06179  ? 181 ALA B CA  1 
ATOM   3409 C  C   . ALA B 1 183 ? -37.43355 41.23810 -79.91392 1.000 39.57169  ? 181 ALA B C   1 
ATOM   3410 O  O   . ALA B 1 183 ? -37.89475 41.54444 -78.80783 1.000 44.64621  ? 181 ALA B O   1 
ATOM   3411 C  CB  . ALA B 1 183 ? -38.80299 40.47438 -81.88977 1.000 35.14533  ? 181 ALA B CB  1 
ATOM   3412 N  N   . LEU B 1 184 ? -36.29376 40.54339 -80.04181 1.000 40.41511  ? 182 LEU B N   1 
ATOM   3413 C  CA  . LEU B 1 184 ? -35.54146 40.13541 -78.85942 1.000 40.53066  ? 182 LEU B CA  1 
ATOM   3414 C  C   . LEU B 1 184 ? -35.14070 41.33629 -78.02223 1.000 36.07893  ? 182 LEU B C   1 
ATOM   3415 O  O   . LEU B 1 184 ? -35.19286 41.27592 -76.78756 1.000 42.49484  ? 182 LEU B O   1 
ATOM   3416 C  CB  . LEU B 1 184 ? -34.29818 39.33352 -79.24671 1.000 35.65483  ? 182 LEU B CB  1 
ATOM   3417 C  CG  . LEU B 1 184 ? -34.54086 37.95153 -79.83711 1.000 40.73991  ? 182 LEU B CG  1 
ATOM   3418 C  CD1 . LEU B 1 184 ? -33.22262 37.28937 -80.21188 1.000 37.71144  ? 182 LEU B CD1 1 
ATOM   3419 C  CD2 . LEU B 1 184 ? -35.35508 37.07633 -78.87617 1.000 36.38036  ? 182 LEU B CD2 1 
ATOM   3420 N  N   . VAL B 1 185 ? -34.75521 42.44099 -78.66801 1.000 32.57320  ? 183 VAL B N   1 
ATOM   3421 C  CA  . VAL B 1 185 ? -34.38384 43.64258 -77.91594 1.000 38.76095  ? 183 VAL B CA  1 
ATOM   3422 C  C   . VAL B 1 185 ? -35.58080 44.16353 -77.13000 1.000 43.33815  ? 183 VAL B C   1 
ATOM   3423 O  O   . VAL B 1 185 ? -35.47447 44.47262 -75.93534 1.000 41.74001  ? 183 VAL B O   1 
ATOM   3424 C  CB  . VAL B 1 185 ? -33.81931 44.73025 -78.84674 1.000 37.57219  ? 183 VAL B CB  1 
ATOM   3425 C  CG1 . VAL B 1 185 ? -33.71902 46.06753 -78.09029 1.000 30.65435  ? 183 VAL B CG1 1 
ATOM   3426 C  CG2 . VAL B 1 185 ? -32.46763 44.32906 -79.40405 1.000 34.22428  ? 183 VAL B CG2 1 
ATOM   3427 N  N   . ARG B 1 186 ? -36.74126 44.25967 -77.78870 1.000 35.14558  ? 184 ARG B N   1 
ATOM   3428 C  CA  . ARG B 1 186 ? -37.93542 44.72576 -77.09835 1.000 42.15791  ? 184 ARG B CA  1 
ATOM   3429 C  C   . ARG B 1 186 ? -38.24037 43.85709 -75.88473 1.000 35.91414  ? 184 ARG B C   1 
ATOM   3430 O  O   . ARG B 1 186 ? -38.53343 44.36608 -74.80115 1.000 36.33803  ? 184 ARG B O   1 
ATOM   3431 C  CB  . ARG B 1 186 ? -39.14126 44.74515 -78.03665 1.000 36.84002  ? 184 ARG B CB  1 
ATOM   3432 C  CG  . ARG B 1 186 ? -40.34712 45.23297 -77.27986 1.000 47.15897  ? 184 ARG B CG  1 
ATOM   3433 C  CD  . ARG B 1 186 ? -41.64865 44.78477 -77.85600 1.000 45.66090  ? 184 ARG B CD  1 
ATOM   3434 N  NE  . ARG B 1 186 ? -41.88173 43.36291 -77.67746 1.000 50.87887  ? 184 ARG B NE  1 
ATOM   3435 C  CZ  . ARG B 1 186 ? -42.68995 42.83333 -76.76868 1.000 45.34838  ? 184 ARG B CZ  1 
ATOM   3436 N  NH1 . ARG B 1 186 ? -43.25561 43.57197 -75.83010 1.000 47.72142  ? 184 ARG B NH1 1 
ATOM   3437 N  NH2 . ARG B 1 186 ? -42.94759 41.52937 -76.81561 1.000 42.17263  ? 184 ARG B NH2 1 
ATOM   3438 N  N   . GLU B 1 187 ? -38.17958 42.53965 -76.05586 1.000 41.01039  ? 185 GLU B N   1 
ATOM   3439 C  CA  . GLU B 1 187 ? -38.49141 41.63890 -74.95338 1.000 38.91493  ? 185 GLU B CA  1 
ATOM   3440 C  C   . GLU B 1 187 ? -37.51796 41.85648 -73.80036 1.000 37.69443  ? 185 GLU B C   1 
ATOM   3441 O  O   . GLU B 1 187 ? -37.91716 41.91611 -72.63345 1.000 44.70852  ? 185 GLU B O   1 
ATOM   3442 C  CB  . GLU B 1 187 ? -38.43261 40.18837 -75.43271 1.000 33.73395  ? 185 GLU B CB  1 
ATOM   3443 C  CG  . GLU B 1 187 ? -39.62392 39.73417 -76.28245 1.000 41.33845  ? 185 GLU B CG  1 
ATOM   3444 C  CD  . GLU B 1 187 ? -39.21085 38.93805 -77.56702 1.000 53.29749  ? 185 GLU B CD  1 
ATOM   3445 O  OE1 . GLU B 1 187 ? -39.67526 39.29337 -78.68428 1.000 52.43214  ? 185 GLU B OE1 1 
ATOM   3446 O  OE2 . GLU B 1 187 ? -38.48734 37.90161 -77.44404 1.000 51.14907  ? 185 GLU B OE2 1 
ATOM   3447 N  N   . ALA B 1 188 ? -36.23484 42.02467 -74.11265 1.000 38.39389  ? 186 ALA B N   1 
ATOM   3448 C  CA  . ALA B 1 188 ? -35.25947 42.26271 -73.05743 1.000 36.10855  ? 186 ALA B CA  1 
ATOM   3449 C  C   . ALA B 1 188 ? -35.46641 43.62609 -72.39906 1.000 38.15150  ? 186 ALA B C   1 
ATOM   3450 O  O   . ALA B 1 188 ? -35.30019 43.75627 -71.18027 1.000 41.84156  ? 186 ALA B O   1 
ATOM   3451 C  CB  . ALA B 1 188 ? -33.83706 42.13185 -73.60352 1.000 36.18735  ? 186 ALA B CB  1 
ATOM   3452 N  N   . MET B 1 189 ? -35.83063 44.65401 -73.17520 1.000 38.28861  ? 187 MET B N   1 
ATOM   3453 C  CA  . MET B 1 189 ? -36.18269 45.92302 -72.55110 1.000 40.41959  ? 187 MET B CA  1 
ATOM   3454 C  C   . MET B 1 189 ? -37.41369 45.79232 -71.66246 1.000 40.05349  ? 187 MET B C   1 
ATOM   3455 O  O   . MET B 1 189 ? -37.47670 46.41113 -70.59775 1.000 40.84100  ? 187 MET B O   1 
ATOM   3456 C  CB  . MET B 1 189 ? -36.40354 47.02879 -73.58475 1.000 36.89240  ? 187 MET B CB  1 
ATOM   3457 C  CG  . MET B 1 189 ? -35.20380 47.34288 -74.46026 1.000 41.17514  ? 187 MET B CG  1 
ATOM   3458 S  SD  . MET B 1 189 ? -35.65598 48.52141 -75.75054 1.000 43.94556  ? 187 MET B SD  1 
ATOM   3459 C  CE  . MET B 1 189 ? -35.69396 50.05067 -74.78112 1.000 44.90797  ? 187 MET B CE  1 
ATOM   3460 N  N   . LEU B 1 190 ? -38.41205 45.02122 -72.08437 1.000 40.42214  ? 188 LEU B N   1 
ATOM   3461 C  CA  . LEU B 1 190 ? -39.59184 44.88506 -71.24532 1.000 38.33797  ? 188 LEU B CA  1 
ATOM   3462 C  C   . LEU B 1 190 ? -39.23097 44.22560 -69.92276 1.000 37.53920  ? 188 LEU B C   1 
ATOM   3463 O  O   . LEU B 1 190 ? -39.72171 44.63580 -68.86595 1.000 39.30071  ? 188 LEU B O   1 
ATOM   3464 C  CB  . LEU B 1 190 ? -40.67977 44.09374 -71.97108 1.000 41.02875  ? 188 LEU B CB  1 
ATOM   3465 C  CG  . LEU B 1 190 ? -42.10815 44.12391 -71.38300 1.000 48.50999  ? 188 LEU B CG  1 
ATOM   3466 C  CD1 . LEU B 1 190 ? -42.54492 45.53781 -70.96678 1.000 42.22861  ? 188 LEU B CD1 1 
ATOM   3467 C  CD2 . LEU B 1 190 ? -43.10147 43.56190 -72.38925 1.000 48.23083  ? 188 LEU B CD2 1 
ATOM   3468 N  N   . ARG B 1 191 ? -38.33839 43.23321 -69.95728 1.000 37.99085  ? 189 ARG B N   1 
ATOM   3469 C  CA  . ARG B 1 191 ? -37.94767 42.53894 -68.73171 1.000 40.22633  ? 189 ARG B CA  1 
ATOM   3470 C  C   . ARG B 1 191 ? -37.17214 43.45885 -67.80173 1.000 38.92284  ? 189 ARG B C   1 
ATOM   3471 O  O   . ARG B 1 191 ? -37.35692 43.41661 -66.57879 1.000 42.00320  ? 189 ARG B O   1 
ATOM   3472 C  CB  . ARG B 1 191 ? -37.12222 41.29328 -69.05948 1.000 35.94676  ? 189 ARG B CB  1 
ATOM   3473 C  CG  . ARG B 1 191 ? -37.96687 40.10873 -69.47692 1.000 36.74123  ? 189 ARG B CG  1 
ATOM   3474 C  CD  . ARG B 1 191 ? -37.16160 38.83147 -69.68484 1.000 28.54650  ? 189 ARG B CD  1 
ATOM   3475 N  NE  . ARG B 1 191 ? -35.99420 39.03649 -70.52957 1.000 39.74816  ? 189 ARG B NE  1 
ATOM   3476 C  CZ  . ARG B 1 191 ? -35.92859 38.74034 -71.82939 1.000 46.28491  ? 189 ARG B CZ  1 
ATOM   3477 N  NH1 . ARG B 1 191 ? -36.95936 38.21898 -72.48672 1.000 41.80263  ? 189 ARG B NH1 1 
ATOM   3478 N  NH2 . ARG B 1 191 ? -34.79971 38.97480 -72.48866 1.000 36.73943  ? 189 ARG B NH2 1 
ATOM   3479 N  N   . LEU B 1 192 ? -36.31319 44.31142 -68.35503 1.000 38.93310  ? 190 LEU B N   1 
ATOM   3480 C  CA  . LEU B 1 192 ? -35.65003 45.30648 -67.51798 1.000 38.50188  ? 190 LEU B CA  1 
ATOM   3481 C  C   . LEU B 1 192 ? -36.67012 46.21463 -66.85142 1.000 40.69183  ? 190 LEU B C   1 
ATOM   3482 O  O   . LEU B 1 192 ? -36.60640 46.45676 -65.63980 1.000 40.73015  ? 190 LEU B O   1 
ATOM   3483 C  CB  . LEU B 1 192 ? -34.66401 46.12500 -68.34175 1.000 36.14006  ? 190 LEU B CB  1 
ATOM   3484 C  CG  . LEU B 1 192 ? -33.99720 47.29265 -67.61339 1.000 39.22357  ? 190 LEU B CG  1 
ATOM   3485 C  CD1 . LEU B 1 192 ? -33.13600 46.84374 -66.43742 1.000 32.22333  ? 190 LEU B CD1 1 
ATOM   3486 C  CD2 . LEU B 1 192 ? -33.16333 48.07550 -68.61037 1.000 39.06805  ? 190 LEU B CD2 1 
ATOM   3487 N  N   . ASP B 1 193 ? -37.63932 46.70851 -67.62456 1.000 38.84998  ? 191 ASP B N   1 
ATOM   3488 C  CA  . ASP B 1 193 ? -38.59847 47.63906 -67.05172 1.000 41.74042  ? 191 ASP B CA  1 
ATOM   3489 C  C   . ASP B 1 193 ? -39.44729 46.96131 -65.98139 1.000 42.31325  ? 191 ASP B C   1 
ATOM   3490 O  O   . ASP B 1 193 ? -39.68658 47.54802 -64.91906 1.000 37.75254  ? 191 ASP B O   1 
ATOM   3491 C  CB  . ASP B 1 193 ? -39.46692 48.25754 -68.15096 1.000 45.76201  ? 191 ASP B CB  1 
ATOM   3492 C  CG  . ASP B 1 193 ? -39.95959 49.67949 -67.77699 1.000 58.49796  ? 191 ASP B CG  1 
ATOM   3493 O  OD1 . ASP B 1 193 ? -39.72224 50.12960 -66.61762 1.000 58.21536  ? 191 ASP B OD1 1 
ATOM   3494 O  OD2 . ASP B 1 193 ? -40.55955 50.35612 -68.64184 1.000 49.15737  ? 191 ASP B OD2 1 
ATOM   3495 N  N   . GLY B 1 194 ? -39.85907 45.70557 -66.22487 1.000 38.02026  ? 192 GLY B N   1 
ATOM   3496 C  CA  . GLY B 1 194 ? -40.60539 44.95768 -65.23065 1.000 34.19078  ? 192 GLY B CA  1 
ATOM   3497 C  C   . GLY B 1 194 ? -39.83057 44.76921 -63.94209 1.000 41.90550  ? 192 GLY B C   1 
ATOM   3498 O  O   . GLY B 1 194 ? -40.40510 44.79967 -62.84561 1.000 42.61379  ? 192 GLY B O   1 
ATOM   3499 N  N   . SER B 1 195 ? -38.51797 44.60712 -64.05691 1.000 37.15401  ? 193 SER B N   1 
ATOM   3500 C  CA  . SER B 1 195 ? -37.66513 44.44784 -62.89486 1.000 33.63065  ? 193 SER B CA  1 
ATOM   3501 C  C   . SER B 1 195 ? -37.55083 45.75954 -62.12511 1.000 39.99715  ? 193 SER B C   1 
ATOM   3502 O  O   . SER B 1 195 ? -37.64320 45.77157 -60.89365 1.000 36.16563  ? 193 SER B O   1 
ATOM   3503 C  CB  . SER B 1 195 ? -36.30428 43.93392 -63.35845 1.000 33.87330  ? 193 SER B CB  1 
ATOM   3504 O  OG  . SER B 1 195 ? -35.37144 43.92494 -62.31115 1.000 39.02202  ? 193 SER B OG  1 
ATOM   3505 N  N   . VAL B 1 196 ? -37.39973 46.88336 -62.82774 1.000 35.94815  ? 194 VAL B N   1 
ATOM   3506 C  CA  . VAL B 1 196 ? -37.38482 48.16542 -62.12420 1.000 43.22963  ? 194 VAL B CA  1 
ATOM   3507 C  C   . VAL B 1 196 ? -38.74003 48.45721 -61.47061 1.000 43.67900  ? 194 VAL B C   1 
ATOM   3508 O  O   . VAL B 1 196 ? -38.79236 48.93414 -60.33231 1.000 41.61325  ? 194 VAL B O   1 
ATOM   3509 C  CB  . VAL B 1 196 ? -36.95914 49.30729 -63.06172 1.000 44.39244  ? 194 VAL B CB  1 
ATOM   3510 C  CG1 . VAL B 1 196 ? -36.90094 50.59470 -62.27304 1.000 44.37855  ? 194 VAL B CG1 1 
ATOM   3511 C  CG2 . VAL B 1 196 ? -35.60946 49.01070 -63.66350 1.000 35.74907  ? 194 VAL B CG2 1 
ATOM   3512 N  N   . LEU B 1 197 ? -39.85429 48.19112 -62.16836 1.000 40.37913  ? 195 LEU B N   1 
ATOM   3513 C  CA  . LEU B 1 197 ? -41.15464 48.30170 -61.50883 1.000 39.91509  ? 195 LEU B CA  1 
ATOM   3514 C  C   . LEU B 1 197 ? -41.22519 47.38810 -60.28958 1.000 41.60651  ? 195 LEU B C   1 
ATOM   3515 O  O   . LEU B 1 197 ? -41.81701 47.74838 -59.26571 1.000 45.79381  ? 195 LEU B O   1 
ATOM   3516 C  CB  . LEU B 1 197 ? -42.29101 47.96462 -62.47584 1.000 34.40164  ? 195 LEU B CB  1 
ATOM   3517 C  CG  . LEU B 1 197 ? -42.65218 49.01775 -63.51906 1.000 46.40939  ? 195 LEU B CG  1 
ATOM   3518 C  CD1 . LEU B 1 197 ? -43.75948 48.50998 -64.44078 1.000 48.24775  ? 195 LEU B CD1 1 
ATOM   3519 C  CD2 . LEU B 1 197 ? -43.06624 50.32405 -62.86571 1.000 47.09118  ? 195 LEU B CD2 1 
ATOM   3520 N  N   . GLY B 1 198 ? -40.64039 46.19465 -60.38325 1.000 38.58565  ? 196 GLY B N   1 
ATOM   3521 C  CA  . GLY B 1 198 ? -40.62568 45.30969 -59.23128 1.000 38.02136  ? 196 GLY B CA  1 
ATOM   3522 C  C   . GLY B 1 198 ? -39.86810 45.91649 -58.06527 1.000 39.88898  ? 196 GLY B C   1 
ATOM   3523 O  O   . GLY B 1 198 ? -40.29303 45.81126 -56.91244 1.000 37.16895  ? 196 GLY B O   1 
ATOM   3524 N  N   . TRP B 1 199 ? -38.74100 46.57001 -58.35294 1.000 32.71913  ? 197 TRP B N   1 
ATOM   3525 C  CA  . TRP B 1 199 ? -38.00575 47.25764 -57.30382 1.000 34.02295  ? 197 TRP B CA  1 
ATOM   3526 C  C   . TRP B 1 199 ? -38.88829 48.29600 -56.63630 1.000 40.94390  ? 197 TRP B C   1 
ATOM   3527 O  O   . TRP B 1 199 ? -38.92843 48.39191 -55.40472 1.000 37.32363  ? 197 TRP B O   1 
ATOM   3528 C  CB  . TRP B 1 199 ? -36.74027 47.92248 -57.85346 1.000 31.31532  ? 197 TRP B CB  1 
ATOM   3529 C  CG  . TRP B 1 199 ? -35.98522 48.56119 -56.74040 1.000 37.43702  ? 197 TRP B CG  1 
ATOM   3530 C  CD1 . TRP B 1 199 ? -35.02513 47.97977 -55.98198 1.000 35.13505  ? 197 TRP B CD1 1 
ATOM   3531 C  CD2 . TRP B 1 199 ? -36.16080 49.89428 -56.21874 1.000 36.48955  ? 197 TRP B CD2 1 
ATOM   3532 N  NE1 . TRP B 1 199 ? -34.58738 48.85749 -55.01150 1.000 39.02291  ? 197 TRP B NE1 1 
ATOM   3533 C  CE2 . TRP B 1 199 ? -35.26675 50.03799 -55.13494 1.000 35.10807  ? 197 TRP B CE2 1 
ATOM   3534 C  CE3 . TRP B 1 199 ? -36.98161 50.97718 -56.56588 1.000 36.66441  ? 197 TRP B CE3 1 
ATOM   3535 C  CZ2 . TRP B 1 199 ? -35.17562 51.21745 -54.37819 1.000 39.45573  ? 197 TRP B CZ2 1 
ATOM   3536 C  CZ3 . TRP B 1 199 ? -36.88145 52.15827 -55.82535 1.000 38.08444  ? 197 TRP B CZ3 1 
ATOM   3537 C  CH2 . TRP B 1 199 ? -35.98535 52.26596 -54.73930 1.000 38.26469  ? 197 TRP B CH2 1 
ATOM   3538 N  N   . LYS B 1 200 ? -39.62114 49.07645 -57.44032 1.000 38.94848  ? 198 LYS B N   1 
ATOM   3539 C  CA  . LYS B 1 200 ? -40.44699 50.13081 -56.86855 1.000 39.65787  ? 198 LYS B CA  1 
ATOM   3540 C  C   . LYS B 1 200 ? -41.54035 49.53537 -55.97634 1.000 41.70812  ? 198 LYS B C   1 
ATOM   3541 O  O   . LYS B 1 200 ? -41.85200 50.08132 -54.91187 1.000 41.81834  ? 198 LYS B O   1 
ATOM   3542 C  CB  . LYS B 1 200 ? -41.06848 50.96046 -57.98471 1.000 40.65630  ? 198 LYS B CB  1 
ATOM   3543 C  CG  . LYS B 1 200 ? -40.28653 52.16802 -58.50848 1.000 41.99483  ? 198 LYS B CG  1 
ATOM   3544 C  CD  . LYS B 1 200 ? -40.56691 52.24322 -59.99022 1.000 50.90774  ? 198 LYS B CD  1 
ATOM   3545 C  CE  . LYS B 1 200 ? -40.68174 53.65685 -60.53950 1.000 64.10284  ? 198 LYS B CE  1 
ATOM   3546 N  NZ  . LYS B 1 200 ? -39.39700 54.29175 -60.92627 1.000 75.02674  ? 198 LYS B NZ  1 
ATOM   3547 N  N   . GLN B 1 201 ? -42.12721 48.40844 -56.39637 1.000 34.82371  ? 199 GLN B N   1 
ATOM   3548 C  CA  . GLN B 1 201 ? -43.16122 47.75330 -55.60335 1.000 38.59697  ? 199 GLN B CA  1 
ATOM   3549 C  C   . GLN B 1 201 ? -42.59294 47.13228 -54.33418 1.000 41.52394  ? 199 GLN B C   1 
ATOM   3550 O  O   . GLN B 1 201 ? -43.21829 47.21150 -53.27645 1.000 42.29679  ? 199 GLN B O   1 
ATOM   3551 C  CB  . GLN B 1 201 ? -43.87948 46.68649 -56.43478 1.000 46.03512  ? 199 GLN B CB  1 
ATOM   3552 C  CG  . GLN B 1 201 ? -44.79126 47.27316 -57.50381 1.000 45.40361  ? 199 GLN B CG  1 
ATOM   3553 C  CD  . GLN B 1 201 ? -45.60871 48.45228 -56.97072 1.000 61.01887  ? 199 GLN B CD  1 
ATOM   3554 O  OE1 . GLN B 1 201 ? -46.41431 48.31491 -56.03087 1.000 61.05214  ? 199 GLN B OE1 1 
ATOM   3555 N  NE2 . GLN B 1 201 ? -45.36750 49.63012 -57.53674 1.000 64.77685  ? 199 GLN B NE2 1 
ATOM   3556 N  N   . HIS B 1 202 ? -41.41932 46.49675 -54.40884 1.000 41.06128  ? 200 HIS B N   1 
ATOM   3557 C  CA  . HIS B 1 202 ? -40.84319 45.93043 -53.19419 1.000 34.88098  ? 200 HIS B CA  1 
ATOM   3558 C  C   . HIS B 1 202 ? -40.37531 47.02157 -52.24198 1.000 39.62979  ? 200 HIS B C   1 
ATOM   3559 O  O   . HIS B 1 202 ? -40.45736 46.84521 -51.01840 1.000 37.07280  ? 200 HIS B O   1 
ATOM   3560 C  CB  . HIS B 1 202 ? -39.69124 44.98229 -53.52483 1.000 32.16209  ? 200 HIS B CB  1 
ATOM   3561 C  CG  . HIS B 1 202 ? -40.14118 43.61558 -53.92393 1.000 42.48465  ? 200 HIS B CG  1 
ATOM   3562 N  ND1 . HIS B 1 202 ? -40.67634 42.71811 -53.02391 1.000 50.71153  ? 200 HIS B ND1 1 
ATOM   3563 C  CD2 . HIS B 1 202 ? -40.17613 43.00389 -55.13432 1.000 41.60535  ? 200 HIS B CD2 1 
ATOM   3564 C  CE1 . HIS B 1 202 ? -41.00085 41.60326 -53.65611 1.000 44.64079  ? 200 HIS B CE1 1 
ATOM   3565 N  NE2 . HIS B 1 202 ? -40.71450 41.75267 -54.93803 1.000 46.73243  ? 200 HIS B NE2 1 
ATOM   3566 N  N   . HIS B 1 203 ? -39.88943 48.14766 -52.77747 1.000 35.16950  ? 201 HIS B N   1 
ATOM   3567 C  CA  . HIS B 1 203 ? -39.52792 49.28675 -51.93221 1.000 37.48792  ? 201 HIS B CA  1 
ATOM   3568 C  C   . HIS B 1 203 ? -40.75302 49.85807 -51.23333 1.000 42.07582  ? 201 HIS B C   1 
ATOM   3569 O  O   . HIS B 1 203 ? -40.67446 50.27525 -50.06721 1.000 41.90391  ? 201 HIS B O   1 
ATOM   3570 C  CB  . HIS B 1 203 ? -38.83350 50.34726 -52.77921 1.000 30.75484  ? 201 HIS B CB  1 
ATOM   3571 C  CG  . HIS B 1 203 ? -38.50029 51.61805 -52.05964 1.000 41.52057  ? 201 HIS B CG  1 
ATOM   3572 N  ND1 . HIS B 1 203 ? -39.28706 52.75037 -52.14321 1.000 35.00956  ? 201 HIS B ND1 1 
ATOM   3573 C  CD2 . HIS B 1 203 ? -37.42509 51.96144 -51.30450 1.000 41.45609  ? 201 HIS B CD2 1 
ATOM   3574 C  CE1 . HIS B 1 203 ? -38.72287 53.72405 -51.44931 1.000 42.97683  ? 201 HIS B CE1 1 
ATOM   3575 N  NE2 . HIS B 1 203 ? -37.59252 53.27303 -50.93095 1.000 37.04385  ? 201 HIS B NE2 1 
ATOM   3576 N  N   . LEU B 1 204 ? -41.89634 49.83462 -51.91359 1.000 37.72192  ? 202 LEU B N   1 
ATOM   3577 C  CA  . LEU B 1 204 ? -43.15189 50.25979 -51.30728 1.000 45.13565  ? 202 LEU B CA  1 
ATOM   3578 C  C   . LEU B 1 204 ? -43.54589 49.34812 -50.14901 1.000 43.46273  ? 202 LEU B C   1 
ATOM   3579 O  O   . LEU B 1 204 ? -43.88435 49.81970 -49.05448 1.000 39.86993  ? 202 LEU B O   1 
ATOM   3580 C  CB  . LEU B 1 204 ? -44.25189 50.27482 -52.37176 1.000 48.07689  ? 202 LEU B CB  1 
ATOM   3581 C  CG  . LEU B 1 204 ? -45.29309 51.37643 -52.25750 1.000 55.12379  ? 202 LEU B CG  1 
ATOM   3582 C  CD1 . LEU B 1 204 ? -44.60790 52.71232 -52.07959 1.000 59.04881  ? 202 LEU B CD1 1 
ATOM   3583 C  CD2 . LEU B 1 204 ? -46.16225 51.37208 -53.50778 1.000 52.12917  ? 202 LEU B CD2 1 
ATOM   3584 N  N   . ILE B 1 205 ? -43.54216 48.03592 -50.38661 1.000 41.81846  ? 203 ILE B N   1 
ATOM   3585 C  CA  . ILE B 1 205 ? -43.89002 47.08820 -49.33565 1.000 44.48317  ? 203 ILE B CA  1 
ATOM   3586 C  C   . ILE B 1 205 ? -42.99236 47.29728 -48.12673 1.000 46.37730  ? 203 ILE B C   1 
ATOM   3587 O  O   . ILE B 1 205 ? -43.44510 47.28331 -46.97195 1.000 46.38475  ? 203 ILE B O   1 
ATOM   3588 C  CB  . ILE B 1 205 ? -43.78595 45.65351 -49.87293 1.000 42.54117  ? 203 ILE B CB  1 
ATOM   3589 C  CG1 . ILE B 1 205 ? -45.00816 45.33258 -50.71650 1.000 46.46164  ? 203 ILE B CG1 1 
ATOM   3590 C  CG2 . ILE B 1 205 ? -43.63081 44.64276 -48.72493 1.000 43.02825  ? 203 ILE B CG2 1 
ATOM   3591 C  CD1 . ILE B 1 205 ? -44.81323 44.11802 -51.60570 1.000 42.36407  ? 203 ILE B CD1 1 
ATOM   3592 N  N   . MET B 1 206 ? -41.70255 47.48916 -48.38042 1.000 42.93892  ? 204 MET B N   1 
ATOM   3593 C  CA  . MET B 1 206 ? -40.75727 47.79609 -47.31879 1.000 40.51357  ? 204 MET B CA  1 
ATOM   3594 C  C   . MET B 1 206 ? -41.19629 49.03830 -46.53624 1.000 45.44187  ? 204 MET B C   1 
ATOM   3595 O  O   . MET B 1 206 ? -41.25302 49.01667 -45.30170 1.000 42.10368  ? 204 MET B O   1 
ATOM   3596 C  CB  . MET B 1 206 ? -39.37716 47.98016 -47.94643 1.000 42.54327  ? 204 MET B CB  1 
ATOM   3597 C  CG  . MET B 1 206 ? -38.21646 47.98539 -47.00238 1.000 40.72067  ? 204 MET B CG  1 
ATOM   3598 S  SD  . MET B 1 206 ? -37.94095 49.68106 -46.50841 1.000 53.07224  ? 204 MET B SD  1 
ATOM   3599 C  CE  . MET B 1 206 ? -37.53634 50.40493 -48.10671 1.000 51.73840  ? 204 MET B CE  1 
ATOM   3600 N  N   . VAL B 1 207 ? -41.54300 50.12272 -47.24393 1.000 41.49094  ? 205 VAL B N   1 
ATOM   3601 C  CA  . VAL B 1 207 ? -41.90339 51.36774 -46.56913 1.000 44.38569  ? 205 VAL B CA  1 
ATOM   3602 C  C   . VAL B 1 207 ? -43.17565 51.18961 -45.75120 1.000 45.56918  ? 205 VAL B C   1 
ATOM   3603 O  O   . VAL B 1 207 ? -43.28097 51.70576 -44.63468 1.000 45.66149  ? 205 VAL B O   1 
ATOM   3604 C  CB  . VAL B 1 207 ? -42.04382 52.52278 -47.57764 1.000 41.30690  ? 205 VAL B CB  1 
ATOM   3605 C  CG1 . VAL B 1 207 ? -42.77750 53.70186 -46.92595 1.000 41.18814  ? 205 VAL B CG1 1 
ATOM   3606 C  CG2 . VAL B 1 207 ? -40.67074 52.96689 -48.09514 1.000 36.47471  ? 205 VAL B CG2 1 
ATOM   3607 N  N   . TRP B 1 208 ? -44.15668 50.45405 -46.27849 1.000 38.34809  ? 206 TRP B N   1 
ATOM   3608 C  CA  . TRP B 1 208 ? -45.35283 50.18538 -45.48799 1.000 42.88257  ? 206 TRP B CA  1 
ATOM   3609 C  C   . TRP B 1 208 ? -44.99882 49.45512 -44.20302 1.000 47.36287  ? 206 TRP B C   1 
ATOM   3610 O  O   . TRP B 1 208 ? -45.59816 49.70539 -43.15002 1.000 45.12872  ? 206 TRP B O   1 
ATOM   3611 C  CB  . TRP B 1 208 ? -46.36954 49.37467 -46.28594 1.000 42.88031  ? 206 TRP B CB  1 
ATOM   3612 C  CG  . TRP B 1 208 ? -46.89788 50.08992 -47.48633 1.000 47.50486  ? 206 TRP B CG  1 
ATOM   3613 C  CD1 . TRP B 1 208 ? -46.97746 51.44498 -47.67697 1.000 47.26248  ? 206 TRP B CD1 1 
ATOM   3614 C  CD2 . TRP B 1 208 ? -47.40399 49.48636 -48.67496 1.000 45.73443  ? 206 TRP B CD2 1 
ATOM   3615 N  NE1 . TRP B 1 208 ? -47.51425 51.71727 -48.91237 1.000 49.70288  ? 206 TRP B NE1 1 
ATOM   3616 C  CE2 . TRP B 1 208 ? -47.78276 50.53155 -49.54653 1.000 49.65024  ? 206 TRP B CE2 1 
ATOM   3617 C  CE3 . TRP B 1 208 ? -47.57846 48.15612 -49.09008 1.000 50.67492  ? 206 TRP B CE3 1 
ATOM   3618 C  CZ2 . TRP B 1 208 ? -48.31946 50.28942 -50.81332 1.000 54.51840  ? 206 TRP B CZ2 1 
ATOM   3619 C  CZ3 . TRP B 1 208 ? -48.12046 47.91545 -50.34426 1.000 49.12372  ? 206 TRP B CZ3 1 
ATOM   3620 C  CH2 . TRP B 1 208 ? -48.48571 48.97818 -51.19200 1.000 44.25761  ? 206 TRP B CH2 1 
ATOM   3621 N  N   . SER B 1 209 ? -44.01640 48.56262 -44.26355 1.000 43.86358  ? 207 SER B N   1 
ATOM   3622 C  CA  . SER B 1 209 ? -43.64223 47.80048 -43.08301 1.000 40.32548  ? 207 SER B CA  1 
ATOM   3623 C  C   . SER B 1 209 ? -42.77498 48.59729 -42.11777 1.000 45.67643  ? 207 SER B C   1 
ATOM   3624 O  O   . SER B 1 209 ? -42.56979 48.14285 -40.98996 1.000 47.70748  ? 207 SER B O   1 
ATOM   3625 C  CB  . SER B 1 209 ? -42.92113 46.50618 -43.49985 1.000 42.69817  ? 207 SER B CB  1 
ATOM   3626 O  OG  . SER B 1 209 ? -41.53314 46.74104 -43.73767 1.000 47.48182  ? 207 SER B OG  1 
ATOM   3627 N  N   . GLN B 1 210 ? -42.25404 49.76032 -42.52187 1.000 44.94361  ? 208 GLN B N   1 
ATOM   3628 C  CA  . GLN B 1 210 ? -41.39875 50.55976 -41.64900 1.000 48.17583  ? 208 GLN B CA  1 
ATOM   3629 C  C   . GLN B 1 210 ? -42.02547 51.88075 -41.20535 1.000 44.15500  ? 208 GLN B C   1 
ATOM   3630 O  O   . GLN B 1 210 ? -41.80303 52.30430 -40.07500 1.000 52.05397  ? 208 GLN B O   1 
ATOM   3631 C  CB  . GLN B 1 210 ? -40.04776 50.84278 -42.33056 1.000 42.60295  ? 208 GLN B CB  1 
ATOM   3632 C  CG  . GLN B 1 210 ? -39.28073 49.58300 -42.78390 1.000 42.74261  ? 208 GLN B CG  1 
ATOM   3633 C  CD  . GLN B 1 210 ? -38.53745 48.86472 -41.65726 1.000 48.97614  ? 208 GLN B CD  1 
ATOM   3634 O  OE1 . GLN B 1 210 ? -38.01835 49.49719 -40.73387 1.000 51.86902  ? 208 GLN B OE1 1 
ATOM   3635 N  NE2 . GLN B 1 210 ? -38.46916 47.53958 -41.73945 1.000 50.85197  ? 208 GLN B NE2 1 
ATOM   3636 N  N   . LEU B 1 211 ? -42.82118 52.51951 -42.04495 1.000 43.16412  ? 209 LEU B N   1 
ATOM   3637 C  CA  . LEU B 1 211 ? -43.44189 53.79354 -41.73336 1.000 47.19292  ? 209 LEU B CA  1 
ATOM   3638 C  C   . LEU B 1 211 ? -44.96510 53.73799 -41.75252 1.000 47.76954  ? 209 LEU B C   1 
ATOM   3639 O  O   . LEU B 1 211 ? -45.60803 54.77518 -41.55970 1.000 51.79407  ? 209 LEU B O   1 
ATOM   3640 C  CB  . LEU B 1 211 ? -42.96077 54.86588 -42.72585 1.000 48.69812  ? 209 LEU B CB  1 
ATOM   3641 C  CG  . LEU B 1 211 ? -41.45226 55.03872 -42.86601 1.000 50.58284  ? 209 LEU B CG  1 
ATOM   3642 C  CD1 . LEU B 1 211 ? -41.12048 56.13996 -43.84861 1.000 53.29596  ? 209 LEU B CD1 1 
ATOM   3643 C  CD2 . LEU B 1 211 ? -40.79108 55.30963 -41.51263 1.000 46.87601  ? 209 LEU B CD2 1 
ATOM   3644 N  N   . GLY B 1 212 ? -45.55915 52.57309 -41.99260 1.000 44.21201  ? 210 GLY B N   1 
ATOM   3645 C  CA  . GLY B 1 212 ? -46.99530 52.47085 -42.12951 1.000 45.65831  ? 210 GLY B CA  1 
ATOM   3646 C  C   . GLY B 1 212 ? -47.48409 52.89283 -43.50702 1.000 51.48882  ? 210 GLY B C   1 
ATOM   3647 O  O   . GLY B 1 212 ? -46.72706 53.01139 -44.47004 1.000 55.83308  ? 210 GLY B O   1 
ATOM   3648 N  N   . GLY B 1 213 ? -48.79067 53.11194 -43.59132 1.000 58.65604  ? 211 GLY B N   1 
ATOM   3649 C  CA  . GLY B 1 213 ? -49.40980 53.57978 -44.81414 1.000 57.69567  ? 211 GLY B CA  1 
ATOM   3650 C  C   . GLY B 1 213 ? -49.89748 52.50659 -45.75920 1.000 53.51535  ? 211 GLY B C   1 
ATOM   3651 O  O   . GLY B 1 213 ? -50.27156 52.83150 -46.89197 1.000 62.90670  ? 211 GLY B O   1 
ATOM   3652 N  N   . GLN B 1 214 ? -49.90500 51.24935 -45.34274 1.000 50.31029  ? 212 GLN B N   1 
ATOM   3653 C  CA  . GLN B 1 214 ? -50.37284 50.17516 -46.20533 1.000 53.06990  ? 212 GLN B CA  1 
ATOM   3654 C  C   . GLN B 1 214 ? -51.79136 50.48652 -46.67772 1.000 57.76737  ? 212 GLN B C   1 
ATOM   3655 O  O   . GLN B 1 214 ? -52.67996 50.71142 -45.84109 1.000 60.05734  ? 212 GLN B O   1 
ATOM   3656 C  CB  . GLN B 1 214 ? -50.31640 48.83672 -45.46970 1.000 46.94160  ? 212 GLN B CB  1 
ATOM   3657 C  CG  . GLN B 1 214 ? -50.07771 47.64219 -46.36621 1.000 46.85710  ? 212 GLN B CG  1 
ATOM   3658 C  CD  . GLN B 1 214 ? -51.34610 47.18743 -47.06385 1.000 56.49839  ? 212 GLN B CD  1 
ATOM   3659 O  OE1 . GLN B 1 214 ? -52.42664 47.15524 -46.46445 1.000 56.22718  ? 212 GLN B OE1 1 
ATOM   3660 N  NE2 . GLN B 1 214 ? -51.22576 46.84212 -48.34154 1.000 56.99576  ? 212 GLN B NE2 1 
ATOM   3661 N  N   . PRO B 1 215 ? -52.04008 50.53426 -47.99169 1.000 61.75789  ? 213 PRO B N   1 
ATOM   3662 C  CA  . PRO B 1 215 ? -53.29922 51.10897 -48.49656 1.000 66.90653  ? 213 PRO B CA  1 
ATOM   3663 C  C   . PRO B 1 215 ? -54.50481 50.21966 -48.31324 1.000 70.26315  ? 213 PRO B C   1 
ATOM   3664 O  O   . PRO B 1 215 ? -55.62876 50.70990 -48.47030 1.000 71.93109  ? 213 PRO B O   1 
ATOM   3665 C  CB  . PRO B 1 215 ? -53.01911 51.32891 -49.99062 1.000 59.15121  ? 213 PRO B CB  1 
ATOM   3666 C  CG  . PRO B 1 215 ? -51.55197 51.08051 -50.16881 1.000 68.00706  ? 213 PRO B CG  1 
ATOM   3667 C  CD  . PRO B 1 215 ? -51.15213 50.13410 -49.08901 1.000 61.53347  ? 213 PRO B CD  1 
ATOM   3668 N  N   . GLY B 1 216 ? -54.31639 48.93295 -48.01849 1.000 71.56104  ? 214 GLY B N   1 
ATOM   3669 C  CA  . GLY B 1 216 ? -55.45006 48.07728 -47.72809 1.000 65.25182  ? 214 GLY B CA  1 
ATOM   3670 C  C   . GLY B 1 216 ? -56.19723 48.47304 -46.47188 1.000 69.73643  ? 214 GLY B C   1 
ATOM   3671 O  O   . GLY B 1 216 ? -57.36657 48.11276 -46.31903 1.000 77.90357  ? 214 GLY B O   1 
ATOM   3672 N  N   . LEU B 1 217 ? -55.55053 49.21538 -45.56957 1.000 65.11997  ? 215 LEU B N   1 
ATOM   3673 C  CA  . LEU B 1 217 ? -56.20932 49.61407 -44.33135 1.000 73.05092  ? 215 LEU B CA  1 
ATOM   3674 C  C   . LEU B 1 217 ? -57.29186 50.65639 -44.58154 1.000 82.20829  ? 215 LEU B C   1 
ATOM   3675 O  O   . LEU B 1 217 ? -58.30118 50.68342 -43.86625 1.000 91.84863  ? 215 LEU B O   1 
ATOM   3676 C  CB  . LEU B 1 217 ? -55.17257 50.13687 -43.33244 1.000 65.46364  ? 215 LEU B CB  1 
ATOM   3677 C  CG  . LEU B 1 217 ? -53.94126 49.24031 -43.17954 1.000 62.36641  ? 215 LEU B CG  1 
ATOM   3678 C  CD1 . LEU B 1 217 ? -52.81983 49.93309 -42.40375 1.000 57.28101  ? 215 LEU B CD1 1 
ATOM   3679 C  CD2 . LEU B 1 217 ? -54.32741 47.89748 -42.54783 1.000 54.45365  ? 215 LEU B CD2 1 
ATOM   3680 N  N   . ARG B 1 218 ? -57.10937 51.50482 -45.59059 1.000 89.17886  ? 216 ARG B N   1 
ATOM   3681 C  CA  . ARG B 1 218 ? -58.05212 52.58722 -45.89486 1.000 100.13127 ? 216 ARG B CA  1 
ATOM   3682 C  C   . ARG B 1 218 ? -59.39950 52.05645 -46.39490 1.000 97.01805  ? 216 ARG B C   1 
ATOM   3683 O  O   . ARG B 1 218 ? -60.45904 52.53742 -45.98311 1.000 98.09241  ? 216 ARG B O   1 
ATOM   3684 C  CB  . ARG B 1 218 ? -57.45074 53.54556 -46.93763 1.000 97.78393  ? 216 ARG B CB  1 
ATOM   3685 C  CG  . ARG B 1 218 ? -56.07620 54.10910 -46.56445 1.000 98.04025  ? 216 ARG B CG  1 
ATOM   3686 C  CD  . ARG B 1 218 ? -56.04508 54.61837 -45.11880 1.000 106.26901 ? 216 ARG B CD  1 
ATOM   3687 N  NE  . ARG B 1 218 ? -55.07611 53.90555 -44.28631 1.000 107.20556 ? 216 ARG B NE  1 
ATOM   3688 C  CZ  . ARG B 1 218 ? -53.75624 54.06157 -44.34114 1.000 97.70125  ? 216 ARG B CZ  1 
ATOM   3689 N  NH1 . ARG B 1 218 ? -53.19122 54.92451 -45.17513 1.000 96.55539  ? 216 ARG B NH1 1 
ATOM   3690 N  NH2 . ARG B 1 218 ? -52.98327 53.33977 -43.53096 1.000 79.91475  ? 216 ARG B NH2 1 
ATOM   3691 N  N   . ARG B 1 237 ? -42.20260 61.23756 -44.50287 1.000 89.44465  ? 235 ARG B N   1 
ATOM   3692 C  CA  . ARG B 1 237 ? -43.23403 60.25415 -44.82799 1.000 87.90587  ? 235 ARG B CA  1 
ATOM   3693 C  C   . ARG B 1 237 ? -44.25356 60.81298 -45.83106 1.000 105.90139 ? 235 ARG B C   1 
ATOM   3694 O  O   . ARG B 1 237 ? -45.42999 61.01839 -45.48261 1.000 106.45673 ? 235 ARG B O   1 
ATOM   3695 C  CB  . ARG B 1 237 ? -43.95063 59.79663 -43.55043 1.000 78.67466  ? 235 ARG B CB  1 
ATOM   3696 C  CG  . ARG B 1 237 ? -44.78467 58.52213 -43.70236 1.000 75.99471  ? 235 ARG B CG  1 
ATOM   3697 C  CD  . ARG B 1 237 ? -46.12346 58.61382 -42.96455 1.000 78.32556  ? 235 ARG B CD  1 
ATOM   3698 N  NE  . ARG B 1 237 ? -46.61765 57.31293 -42.51527 1.000 73.02415  ? 235 ARG B NE  1 
ATOM   3699 C  CZ  . ARG B 1 237 ? -47.90104 56.97230 -42.45173 1.000 69.51808  ? 235 ARG B CZ  1 
ATOM   3700 N  NH1 . ARG B 1 237 ? -48.86340 57.81490 -42.80101 1.000 65.90937  ? 235 ARG B NH1 1 
ATOM   3701 N  NH2 . ARG B 1 237 ? -48.22821 55.75615 -42.02498 1.000 67.49618  ? 235 ARG B NH2 1 
ATOM   3702 N  N   . SER B 1 238 ? -43.80239 61.06375 -47.06735 1.000 98.64959  ? 236 SER B N   1 
ATOM   3703 C  CA  . SER B 1 238 ? -44.67554 61.56947 -48.13711 1.000 95.40626  ? 236 SER B CA  1 
ATOM   3704 C  C   . SER B 1 238 ? -45.11984 60.40610 -49.02844 1.000 90.90947  ? 236 SER B C   1 
ATOM   3705 O  O   . SER B 1 238 ? -44.75383 60.28670 -50.20288 1.000 84.63990  ? 236 SER B O   1 
ATOM   3706 C  CB  . SER B 1 238 ? -43.96704 62.66888 -48.93339 1.000 88.72079  ? 236 SER B CB  1 
ATOM   3707 O  OG  . SER B 1 238 ? -42.57438 62.41948 -49.04521 1.000 85.79444  ? 236 SER B OG  1 
ATOM   3708 N  N   . LEU B 1 239 ? -45.95597 59.54679 -48.43223 1.000 79.61426  ? 237 LEU B N   1 
ATOM   3709 C  CA  . LEU B 1 239 ? -46.27520 58.25611 -49.03239 1.000 74.81100  ? 237 LEU B CA  1 
ATOM   3710 C  C   . LEU B 1 239 ? -47.11111 58.38983 -50.29843 1.000 83.70974  ? 237 LEU B C   1 
ATOM   3711 O  O   . LEU B 1 239 ? -47.04032 57.51865 -51.17547 1.000 76.89017  ? 237 LEU B O   1 
ATOM   3712 C  CB  . LEU B 1 239 ? -47.00278 57.37761 -48.01602 1.000 76.38541  ? 237 LEU B CB  1 
ATOM   3713 C  CG  . LEU B 1 239 ? -46.16758 56.29346 -47.33646 1.000 76.45945  ? 237 LEU B CG  1 
ATOM   3714 C  CD1 . LEU B 1 239 ? -44.87991 56.87516 -46.77980 1.000 79.37578  ? 237 LEU B CD1 1 
ATOM   3715 C  CD2 . LEU B 1 239 ? -46.97338 55.69657 -46.21957 1.000 71.64774  ? 237 LEU B CD2 1 
ATOM   3716 N  N   . ALA B 1 240 ? -47.91172 59.45308 -50.41451 1.000 84.52314  ? 238 ALA B N   1 
ATOM   3717 C  CA  . ALA B 1 240 ? -48.81503 59.56940 -51.55685 1.000 74.07545  ? 238 ALA B CA  1 
ATOM   3718 C  C   . ALA B 1 240 ? -48.04262 59.79338 -52.85298 1.000 71.40681  ? 238 ALA B C   1 
ATOM   3719 O  O   . ALA B 1 240 ? -48.33310 59.16123 -53.87799 1.000 63.98361  ? 238 ALA B O   1 
ATOM   3720 C  CB  . ALA B 1 240 ? -49.82070 60.69667 -51.32143 1.000 80.33726  ? 238 ALA B CB  1 
ATOM   3721 N  N   . THR B 1 241 ? -47.05803 60.69705 -52.83325 1.000 67.41576  ? 239 THR B N   1 
ATOM   3722 C  CA  . THR B 1 241 ? -46.22258 60.87001 -54.01461 1.000 67.52163  ? 239 THR B CA  1 
ATOM   3723 C  C   . THR B 1 241 ? -45.41639 59.60622 -54.30149 1.000 67.68011  ? 239 THR B C   1 
ATOM   3724 O  O   . THR B 1 241 ? -45.23982 59.23762 -55.46644 1.000 69.29886  ? 239 THR B O   1 
ATOM   3725 C  CB  . THR B 1 241 ? -45.29787 62.08179 -53.86048 1.000 72.85870  ? 239 THR B CB  1 
ATOM   3726 O  OG1 . THR B 1 241 ? -44.77631 62.13636 -52.52480 1.000 86.97353  ? 239 THR B OG1 1 
ATOM   3727 C  CG2 . THR B 1 241 ? -46.05472 63.37047 -54.16208 1.000 73.99340  ? 239 THR B CG2 1 
ATOM   3728 N  N   . LEU B 1 242 ? -44.94892 58.91016 -53.25255 1.000 72.22606  ? 240 LEU B N   1 
ATOM   3729 C  CA  . LEU B 1 242 ? -44.20340 57.66417 -53.44489 1.000 63.80719  ? 240 LEU B CA  1 
ATOM   3730 C  C   . LEU B 1 242 ? -45.04073 56.60921 -54.16915 1.000 59.06619  ? 240 LEU B C   1 
ATOM   3731 O  O   . LEU B 1 242 ? -44.57532 55.99669 -55.13773 1.000 57.91440  ? 240 LEU B O   1 
ATOM   3732 C  CB  . LEU B 1 242 ? -43.70956 57.12120 -52.10262 1.000 61.61998  ? 240 LEU B CB  1 
ATOM   3733 C  CG  . LEU B 1 242 ? -42.74070 55.94252 -52.25071 1.000 52.66815  ? 240 LEU B CG  1 
ATOM   3734 C  CD1 . LEU B 1 242 ? -41.44882 56.39038 -52.92975 1.000 49.91329  ? 240 LEU B CD1 1 
ATOM   3735 C  CD2 . LEU B 1 242 ? -42.43466 55.31444 -50.91917 1.000 53.82855  ? 240 LEU B CD2 1 
ATOM   3736 N  N   . GLU B 1 243 ? -46.28179 56.38426 -53.71572 1.000 57.17169  ? 241 GLU B N   1 
ATOM   3737 C  CA  . GLU B 1 243 ? -47.15237 55.40476 -54.36913 1.000 60.88541  ? 241 GLU B CA  1 
ATOM   3738 C  C   . GLU B 1 243 ? -47.41228 55.76295 -55.83332 1.000 66.16954  ? 241 GLU B C   1 
ATOM   3739 O  O   . GLU B 1 243 ? -47.49032 54.87000 -56.68659 1.000 61.76953  ? 241 GLU B O   1 
ATOM   3740 C  CB  . GLU B 1 243 ? -48.47326 55.27445 -53.60417 1.000 60.18192  ? 241 GLU B CB  1 
ATOM   3741 C  CG  . GLU B 1 243 ? -48.49154 54.16424 -52.52716 1.000 79.04378  ? 241 GLU B CG  1 
ATOM   3742 C  CD  . GLU B 1 243 ? -49.08127 54.60661 -51.16933 1.000 79.05760  ? 241 GLU B CD  1 
ATOM   3743 O  OE1 . GLU B 1 243 ? -50.14562 55.26362 -51.17846 1.000 84.01805  ? 241 GLU B OE1 1 
ATOM   3744 O  OE2 . GLU B 1 243 ? -48.50167 54.27197 -50.09727 1.000 70.96132  ? 241 GLU B OE2 1 
ATOM   3745 N  N   . ALA B 1 244 ? -47.51776 57.05656 -56.15180 1.000 60.66008  ? 242 ALA B N   1 
ATOM   3746 C  CA  . ALA B 1 244 ? -47.73494 57.45858 -57.54203 1.000 63.92605  ? 242 ALA B CA  1 
ATOM   3747 C  C   . ALA B 1 244 ? -46.47034 57.26731 -58.37289 1.000 62.85261  ? 242 ALA B C   1 
ATOM   3748 O  O   . ALA B 1 244 ? -46.52398 56.71503 -59.47531 1.000 56.17393  ? 242 ALA B O   1 
ATOM   3749 C  CB  . ALA B 1 244 ? -48.21202 58.91612 -57.61934 1.000 43.55912  ? 242 ALA B CB  1 
ATOM   3750 N  N   . ARG B 1 245 ? -45.31865 57.72223 -57.85848 1.000 62.92145  ? 243 ARG B N   1 
ATOM   3751 C  CA  . ARG B 1 245 ? -44.06337 57.52980 -58.57633 1.000 58.21699  ? 243 ARG B CA  1 
ATOM   3752 C  C   . ARG B 1 245 ? -43.74933 56.04794 -58.77021 1.000 53.47735  ? 243 ARG B C   1 
ATOM   3753 O  O   . ARG B 1 245 ? -43.06042 55.68256 -59.72308 1.000 56.31964  ? 243 ARG B O   1 
ATOM   3754 C  CB  . ARG B 1 245 ? -42.90565 58.20919 -57.84178 1.000 58.78135  ? 243 ARG B CB  1 
ATOM   3755 C  CG  . ARG B 1 245 ? -42.91765 59.73771 -57.81912 1.000 57.38186  ? 243 ARG B CG  1 
ATOM   3756 C  CD  . ARG B 1 245 ? -41.60392 60.26656 -57.19431 1.000 65.53785  ? 243 ARG B CD  1 
ATOM   3757 N  NE  . ARG B 1 245 ? -41.58852 60.18565 -55.73534 1.000 90.09402  ? 243 ARG B NE  1 
ATOM   3758 C  CZ  . ARG B 1 245 ? -41.62672 61.22685 -54.90852 1.000 96.14494  ? 243 ARG B CZ  1 
ATOM   3759 N  NH1 . ARG B 1 245 ? -41.61249 62.47445 -55.36371 1.000 88.71481  ? 243 ARG B NH1 1 
ATOM   3760 N  NH2 . ARG B 1 245 ? -41.65927 61.01029 -53.58896 1.000 87.46535  ? 243 ARG B NH2 1 
ATOM   3761 N  N   . SER B 1 246 ? -44.24186 55.18455 -57.88650 1.000 53.37957  ? 244 SER B N   1 
ATOM   3762 C  CA  . SER B 1 246 ? -43.94370 53.76400 -57.97305 1.000 56.09529  ? 244 SER B CA  1 
ATOM   3763 C  C   . SER B 1 246 ? -44.56304 53.07794 -59.19407 1.000 57.20385  ? 244 SER B C   1 
ATOM   3764 O  O   . SER B 1 246 ? -44.33328 51.88009 -59.38960 1.000 52.78352  ? 244 SER B O   1 
ATOM   3765 C  CB  . SER B 1 246 ? -44.41961 53.06008 -56.71018 1.000 52.93645  ? 244 SER B CB  1 
ATOM   3766 O  OG  . SER B 1 246 ? -45.77536 52.66228 -56.86690 1.000 58.41763  ? 244 SER B OG  1 
ATOM   3767 N  N   . GLN B 1 247 ? -45.35046 53.76235 -60.01614 1.000 54.72292  ? 245 GLN B N   1 
ATOM   3768 C  CA  . GLN B 1 247 ? -45.84088 53.13445 -61.23489 1.000 63.48652  ? 245 GLN B CA  1 
ATOM   3769 C  C   . GLN B 1 247 ? -45.34195 53.82525 -62.50657 1.000 61.83109  ? 245 GLN B C   1 
ATOM   3770 O  O   . GLN B 1 247 ? -45.79071 53.47356 -63.60685 1.000 61.14494  ? 245 GLN B O   1 
ATOM   3771 C  CB  . GLN B 1 247 ? -47.36899 53.05047 -61.20910 1.000 70.99225  ? 245 GLN B CB  1 
ATOM   3772 C  CG  . GLN B 1 247 ? -48.04949 54.25114 -60.58919 1.000 71.89333  ? 245 GLN B CG  1 
ATOM   3773 C  CD  . GLN B 1 247 ? -49.41647 53.90910 -60.00635 1.000 83.58180  ? 245 GLN B CD  1 
ATOM   3774 O  OE1 . GLN B 1 247 ? -49.66130 52.77579 -59.56311 1.000 87.22809  ? 245 GLN B OE1 1 
ATOM   3775 N  NE2 . GLN B 1 247 ? -50.31883 54.88985 -60.01385 1.000 76.91974  ? 245 GLN B NE2 1 
ATOM   3776 N  N   . LEU B 1 248 ? -44.40524 54.76886 -62.38949 1.000 49.87295  ? 246 LEU B N   1 
ATOM   3777 C  CA  . LEU B 1 248 ? -43.73606 55.33464 -63.55364 1.000 52.71125  ? 246 LEU B CA  1 
ATOM   3778 C  C   . LEU B 1 248 ? -42.74017 54.33847 -64.12910 1.000 58.03584  ? 246 LEU B C   1 
ATOM   3779 O  O   . LEU B 1 248 ? -41.75301 53.98970 -63.47297 1.000 58.00537  ? 246 LEU B O   1 
ATOM   3780 C  CB  . LEU B 1 248 ? -43.01368 56.61545 -63.17379 1.000 46.36633  ? 246 LEU B CB  1 
ATOM   3781 C  CG  . LEU B 1 248 ? -43.98714 57.66058 -62.67622 1.000 63.20831  ? 246 LEU B CG  1 
ATOM   3782 C  CD1 . LEU B 1 248 ? -43.21522 58.94307 -62.47519 1.000 54.93057  ? 246 LEU B CD1 1 
ATOM   3783 C  CD2 . LEU B 1 248 ? -45.13853 57.81762 -63.68971 1.000 51.31848  ? 246 LEU B CD2 1 
ATOM   3784 N  N   . ALA B 1 249 ? -42.97894 53.91252 -65.36412 1.000 53.28934  ? 247 ALA B N   1 
ATOM   3785 C  CA  . ALA B 1 249 ? -42.10593 52.96215 -66.03269 1.000 56.83131  ? 247 ALA B CA  1 
ATOM   3786 C  C   . ALA B 1 249 ? -40.85905 53.65024 -66.59348 1.000 49.96111  ? 247 ALA B C   1 
ATOM   3787 O  O   . ALA B 1 249 ? -40.83121 54.86504 -66.81417 1.000 53.66116  ? 247 ALA B O   1 
ATOM   3788 C  CB  . ALA B 1 249 ? -42.86059 52.25224 -67.15642 1.000 42.18827  ? 247 ALA B CB  1 
ATOM   3789 N  N   . LEU B 1 250 ? -39.81195 52.84215 -66.81850 1.000 52.78101  ? 248 LEU B N   1 
ATOM   3790 C  CA  . LEU B 1 250 ? -38.63434 53.31403 -67.55337 1.000 54.46436  ? 248 LEU B CA  1 
ATOM   3791 C  C   . LEU B 1 250 ? -38.96639 53.59786 -69.01214 1.000 52.18036  ? 248 LEU B C   1 
ATOM   3792 O  O   . LEU B 1 250 ? -38.52140 54.60830 -69.57228 1.000 53.07071  ? 248 LEU B O   1 
ATOM   3793 C  CB  . LEU B 1 250 ? -37.51157 52.28154 -67.49128 1.000 47.98724  ? 248 LEU B CB  1 
ATOM   3794 C  CG  . LEU B 1 250 ? -36.55859 52.23274 -66.30940 1.000 49.00239  ? 248 LEU B CG  1 
ATOM   3795 C  CD1 . LEU B 1 250 ? -35.43155 51.30077 -66.69491 1.000 55.55698  ? 248 LEU B CD1 1 
ATOM   3796 C  CD2 . LEU B 1 250 ? -36.02908 53.60794 -65.97526 1.000 45.40203  ? 248 LEU B CD2 1 
ATOM   3797 N  N   . PHE B 1 251 ? -39.74152 52.70987 -69.64234 1.000 42.39177  ? 249 PHE B N   1 
ATOM   3798 C  CA  . PHE B 1 251 ? -40.06676 52.78174 -71.06174 1.000 38.47725  ? 249 PHE B CA  1 
ATOM   3799 C  C   . PHE B 1 251 ? -41.58107 52.82010 -71.26335 1.000 42.28105  ? 249 PHE B C   1 
ATOM   3800 O  O   . PHE B 1 251 ? -42.17046 51.85949 -71.78065 1.000 46.28662  ? 249 PHE B O   1 
ATOM   3801 C  CB  . PHE B 1 251 ? -39.45027 51.59489 -71.80184 1.000 42.22061  ? 249 PHE B CB  1 
ATOM   3802 C  CG  . PHE B 1 251 ? -37.97297 51.40954 -71.54071 1.000 43.85416  ? 249 PHE B CG  1 
ATOM   3803 C  CD1 . PHE B 1 251 ? -37.08414 52.45911 -71.74026 1.000 44.37564  ? 249 PHE B CD1 1 
ATOM   3804 C  CD2 . PHE B 1 251 ? -37.47731 50.18686 -71.09328 1.000 35.18369  ? 249 PHE B CD2 1 
ATOM   3805 C  CE1 . PHE B 1 251 ? -35.71043 52.29166 -71.50864 1.000 45.52305  ? 249 PHE B CE1 1 
ATOM   3806 C  CE2 . PHE B 1 251 ? -36.12344 50.00561 -70.85827 1.000 45.40146  ? 249 PHE B CE2 1 
ATOM   3807 C  CZ  . PHE B 1 251 ? -35.22329 51.06171 -71.06586 1.000 39.04716  ? 249 PHE B CZ  1 
ATOM   3808 N  N   . PRO B 1 252 ? -42.23948 53.92849 -70.90607 1.000 44.00984  ? 250 PRO B N   1 
ATOM   3809 C  CA  . PRO B 1 252 ? -43.71531 53.95017 -70.98816 1.000 44.71473  ? 250 PRO B CA  1 
ATOM   3810 C  C   . PRO B 1 252 ? -44.25907 53.58522 -72.35887 1.000 48.99259  ? 250 PRO B C   1 
ATOM   3811 O  O   . PRO B 1 252 ? -45.36718 53.03553 -72.46197 1.000 50.42844  ? 250 PRO B O   1 
ATOM   3812 C  CB  . PRO B 1 252 ? -44.08285 55.39421 -70.59416 1.000 47.65893  ? 250 PRO B CB  1 
ATOM   3813 C  CG  . PRO B 1 252 ? -42.81590 56.13665 -70.46658 1.000 42.10471  ? 250 PRO B CG  1 
ATOM   3814 C  CD  . PRO B 1 252 ? -41.69404 55.16023 -70.31260 1.000 41.53578  ? 250 PRO B CD  1 
ATOM   3815 N  N   . GLU B 1 253 ? -43.49366 53.83550 -73.41729 1.000 48.66321  ? 251 GLU B N   1 
ATOM   3816 C  CA  . GLU B 1 253 ? -43.96016 53.52031 -74.76100 1.000 44.35158  ? 251 GLU B CA  1 
ATOM   3817 C  C   . GLU B 1 253 ? -44.14299 52.01879 -74.96154 1.000 45.26480  ? 251 GLU B C   1 
ATOM   3818 O  O   . GLU B 1 253 ? -45.02498 51.60404 -75.72149 1.000 44.87461  ? 251 GLU B O   1 
ATOM   3819 C  CB  . GLU B 1 253 ? -42.97583 54.11507 -75.77152 1.000 46.51521  ? 251 GLU B CB  1 
ATOM   3820 C  CG  . GLU B 1 253 ? -42.88873 55.63828 -75.62850 1.000 59.00047  ? 251 GLU B CG  1 
ATOM   3821 C  CD  . GLU B 1 253 ? -41.77145 56.09748 -74.64093 1.000 74.88866  ? 251 GLU B CD  1 
ATOM   3822 O  OE1 . GLU B 1 253 ? -41.20273 55.24295 -73.87483 1.000 61.31392  ? 251 GLU B OE1 1 
ATOM   3823 O  OE2 . GLU B 1 253 ? -41.51696 57.33406 -74.57864 1.000 74.02342  ? 251 GLU B OE2 1 
ATOM   3824 N  N   . LEU B 1 254 ? -43.34654 51.18800 -74.27780 1.000 44.08871  ? 252 LEU B N   1 
ATOM   3825 C  CA  . LEU B 1 254 ? -43.54816 49.74342 -74.37436 1.000 43.53491  ? 252 LEU B CA  1 
ATOM   3826 C  C   . LEU B 1 254 ? -44.86918 49.33087 -73.75100 1.000 44.30511  ? 252 LEU B C   1 
ATOM   3827 O  O   . LEU B 1 254 ? -45.54924 48.42579 -74.25822 1.000 42.71138  ? 252 LEU B O   1 
ATOM   3828 C  CB  . LEU B 1 254 ? -42.40835 48.99117 -73.69707 1.000 47.53581  ? 252 LEU B CB  1 
ATOM   3829 C  CG  . LEU B 1 254 ? -41.10058 49.02720 -74.47513 1.000 49.00947  ? 252 LEU B CG  1 
ATOM   3830 C  CD1 . LEU B 1 254 ? -40.02745 48.21600 -73.74509 1.000 47.74222  ? 252 LEU B CD1 1 
ATOM   3831 C  CD2 . LEU B 1 254 ? -41.32960 48.52792 -75.88800 1.000 44.51679  ? 252 LEU B CD2 1 
ATOM   3832 N  N   . TRP B 1 255 ? -45.23957 49.97470 -72.64240 1.000 40.75870  ? 253 TRP B N   1 
ATOM   3833 C  CA  . TRP B 1 255 ? -46.48749 49.63417 -71.97061 1.000 43.75934  ? 253 TRP B CA  1 
ATOM   3834 C  C   . TRP B 1 255 ? -47.68272 50.16261 -72.75236 1.000 42.45204  ? 253 TRP B C   1 
ATOM   3835 O  O   . TRP B 1 255 ? -48.71031 49.47858 -72.85906 1.000 40.56127  ? 253 TRP B O   1 
ATOM   3836 C  CB  . TRP B 1 255 ? -46.45910 50.16024 -70.52789 1.000 39.76144  ? 253 TRP B CB  1 
ATOM   3837 C  CG  . TRP B 1 255 ? -45.26595 49.62755 -69.78785 1.000 44.97674  ? 253 TRP B CG  1 
ATOM   3838 C  CD1 . TRP B 1 255 ? -44.04236 50.22745 -69.65802 1.000 41.43214  ? 253 TRP B CD1 1 
ATOM   3839 C  CD2 . TRP B 1 255 ? -45.16346 48.35315 -69.11085 1.000 47.04135  ? 253 TRP B CD2 1 
ATOM   3840 N  NE1 . TRP B 1 255 ? -43.19018 49.41480 -68.92865 1.000 46.15596  ? 253 TRP B NE1 1 
ATOM   3841 C  CE2 . TRP B 1 255 ? -43.85042 48.26164 -68.58648 1.000 42.40510  ? 253 TRP B CE2 1 
ATOM   3842 C  CE3 . TRP B 1 255 ? -46.05343 47.28621 -68.90230 1.000 41.21051  ? 253 TRP B CE3 1 
ATOM   3843 C  CZ2 . TRP B 1 255 ? -43.40320 47.14624 -67.87322 1.000 39.07669  ? 253 TRP B CZ2 1 
ATOM   3844 C  CZ3 . TRP B 1 255 ? -45.60824 46.18011 -68.19223 1.000 46.13198  ? 253 TRP B CZ3 1 
ATOM   3845 C  CH2 . TRP B 1 255 ? -44.29419 46.12424 -67.67802 1.000 42.49638  ? 253 TRP B CH2 1 
ATOM   3846 N  N   . ARG B 1 256 ? -47.55137 51.36454 -73.32923 1.000 40.86434  ? 254 ARG B N   1 
ATOM   3847 C  CA  . ARG B 1 256 ? -48.56537 51.87113 -74.25325 1.000 47.79234  ? 254 ARG B CA  1 
ATOM   3848 C  C   . ARG B 1 256 ? -48.79441 50.88991 -75.39533 1.000 43.60440  ? 254 ARG B C   1 
ATOM   3849 O  O   . ARG B 1 256 ? -49.94543 50.57427 -75.73008 1.000 42.56165  ? 254 ARG B O   1 
ATOM   3850 C  CB  . ARG B 1 256 ? -48.14287 53.24232 -74.79998 1.000 51.19218  ? 254 ARG B CB  1 
ATOM   3851 C  CG  . ARG B 1 256 ? -49.28111 54.22710 -75.00655 1.000 53.99339  ? 254 ARG B CG  1 
ATOM   3852 C  CD  . ARG B 1 256 ? -48.77666 55.64527 -75.29577 1.000 59.73010  ? 254 ARG B CD  1 
ATOM   3853 N  NE  . ARG B 1 256 ? -48.34059 56.37105 -74.10464 1.000 67.72343  ? 254 ARG B NE  1 
ATOM   3854 C  CZ  . ARG B 1 256 ? -47.11235 56.84729 -73.91429 1.000 74.02420  ? 254 ARG B CZ  1 
ATOM   3855 N  NH1 . ARG B 1 256 ? -46.15395 56.69619 -74.82700 1.000 72.75812  ? 254 ARG B NH1 1 
ATOM   3856 N  NH2 . ARG B 1 256 ? -46.83372 57.48703 -72.77846 1.000 68.49668  ? 254 ARG B NH2 1 
ATOM   3857 N  N   . ALA B 1 257 ? -47.70121 50.35876 -75.97203 1.000 40.18649  ? 255 ALA B N   1 
ATOM   3858 C  CA  . ALA B 1 257 ? -47.80947 49.39966 -77.07453 1.000 40.82793  ? 255 ALA B CA  1 
ATOM   3859 C  C   . ALA B 1 257 ? -48.51652 48.12131 -76.63837 1.000 47.86150  ? 255 ALA B C   1 
ATOM   3860 O  O   . ALA B 1 257 ? -49.29875 47.53576 -77.40779 1.000 45.33561  ? 255 ALA B O   1 
ATOM   3861 C  CB  . ALA B 1 257 ? -46.41987 49.07863 -77.62350 1.000 38.13457  ? 255 ALA B CB  1 
ATOM   3862 N  N   . ALA B 1 258 ? -48.24337 47.66244 -75.40839 1.000 45.66458  ? 256 ALA B N   1 
ATOM   3863 C  CA  . ALA B 1 258 ? -48.99460 46.53851 -74.86273 1.000 42.47263  ? 256 ALA B CA  1 
ATOM   3864 C  C   . ALA B 1 258 ? -50.48229 46.85739 -74.82714 1.000 41.40078  ? 256 ALA B C   1 
ATOM   3865 O  O   . ALA B 1 258 ? -51.32091 46.00575 -75.14970 1.000 37.57068  ? 256 ALA B O   1 
ATOM   3866 C  CB  . ALA B 1 258 ? -48.47843 46.19207 -73.46117 1.000 37.86149  ? 256 ALA B CB  1 
ATOM   3867 N  N   . GLU B 1 259 ? -50.82886 48.09202 -74.44875 1.000 42.57451  ? 257 GLU B N   1 
ATOM   3868 C  CA  . GLU B 1 259 ? -52.23519 48.46997 -74.39093 1.000 46.95941  ? 257 GLU B CA  1 
ATOM   3869 C  C   . GLU B 1 259 ? -52.83793 48.54968 -75.78892 1.000 45.40919  ? 257 GLU B C   1 
ATOM   3870 O  O   . GLU B 1 259 ? -53.95489 48.07114 -76.01985 1.000 44.42362  ? 257 GLU B O   1 
ATOM   3871 C  CB  . GLU B 1 259 ? -52.37942 49.79543 -73.65203 1.000 42.48914  ? 257 GLU B CB  1 
ATOM   3872 C  CG  . GLU B 1 259 ? -53.80376 50.28529 -73.57695 1.000 56.03760  ? 257 GLU B CG  1 
ATOM   3873 C  CD  . GLU B 1 259 ? -54.10529 50.93631 -72.24368 1.000 78.95660  ? 257 GLU B CD  1 
ATOM   3874 O  OE1 . GLU B 1 259 ? -53.15186 51.48235 -71.62967 1.000 75.41479  ? 257 GLU B OE1 1 
ATOM   3875 O  OE2 . GLU B 1 259 ? -55.29014 50.91547 -71.82087 1.000 85.91462  ? 257 GLU B OE2 1 
ATOM   3876 N  N   . ASP B 1 260 ? -52.09961 49.13639 -76.73670 1.000 45.70416  ? 258 ASP B N   1 
ATOM   3877 C  CA  . ASP B 1 260 ? -52.49811 49.11280 -78.14424 1.000 42.04384  ? 258 ASP B CA  1 
ATOM   3878 C  C   . ASP B 1 260 ? -52.83875 47.71747 -78.61867 1.000 48.88884  ? 258 ASP B C   1 
ATOM   3879 O  O   . ASP B 1 260 ? -53.88297 47.50333 -79.24796 1.000 50.22530  ? 258 ASP B O   1 
ATOM   3880 C  CB  . ASP B 1 260 ? -51.37146 49.62515 -79.00890 1.000 54.20230  ? 258 ASP B CB  1 
ATOM   3881 C  CG  . ASP B 1 260 ? -51.63285 50.96549 -79.53264 1.000 61.37094  ? 258 ASP B CG  1 
ATOM   3882 O  OD1 . ASP B 1 260 ? -51.00209 51.28285 -80.56930 1.000 67.34126  ? 258 ASP B OD1 1 
ATOM   3883 O  OD2 . ASP B 1 260 ? -52.42561 51.69767 -78.89036 1.000 60.02590  ? 258 ASP B OD2 1 
ATOM   3884 N  N   . ALA B 1 261 ? -51.92574 46.75793 -78.38570 1.000 47.52518  ? 259 ALA B N   1 
ATOM   3885 C  CA  . ALA B 1 261 ? -52.15572 45.39614 -78.87074 1.000 44.42822  ? 259 ALA B CA  1 
ATOM   3886 C  C   . ALA B 1 261 ? -53.46462 44.82964 -78.33084 1.000 42.47998  ? 259 ALA B C   1 
ATOM   3887 O  O   . ALA B 1 261 ? -54.25304 44.24390 -79.08333 1.000 42.77336  ? 259 ALA B O   1 
ATOM   3888 C  CB  . ALA B 1 261 ? -50.97795 44.49899 -78.49984 1.000 40.50668  ? 259 ALA B CB  1 
ATOM   3889 N  N   . TYR B 1 262 ? -53.73248 45.03198 -77.03825 1.000 38.19819  ? 260 TYR B N   1 
ATOM   3890 C  CA  . TYR B 1 262 ? -55.01075 44.60656 -76.46742 1.000 45.07775  ? 260 TYR B CA  1 
ATOM   3891 C  C   . TYR B 1 262 ? -56.19758 45.16617 -77.24766 1.000 42.73983  ? 260 TYR B C   1 
ATOM   3892 O  O   . TYR B 1 262 ? -57.12412 44.42852 -77.60707 1.000 43.58559  ? 260 TYR B O   1 
ATOM   3893 C  CB  . TYR B 1 262 ? -55.10771 45.03446 -75.00103 1.000 43.25319  ? 260 TYR B CB  1 
ATOM   3894 C  CG  . TYR B 1 262 ? -56.48274 44.82216 -74.42150 1.000 43.43539  ? 260 TYR B CG  1 
ATOM   3895 C  CD1 . TYR B 1 262 ? -56.96172 43.53695 -74.18245 1.000 44.35285  ? 260 TYR B CD1 1 
ATOM   3896 C  CD2 . TYR B 1 262 ? -57.31525 45.90154 -74.12650 1.000 46.89673  ? 260 TYR B CD2 1 
ATOM   3897 C  CE1 . TYR B 1 262 ? -58.21483 43.32114 -73.64489 1.000 42.67065  ? 260 TYR B CE1 1 
ATOM   3898 C  CE2 . TYR B 1 262 ? -58.57552 45.69386 -73.59487 1.000 54.40447  ? 260 TYR B CE2 1 
ATOM   3899 C  CZ  . TYR B 1 262 ? -59.01813 44.39449 -73.35575 1.000 49.25450  ? 260 TYR B CZ  1 
ATOM   3900 O  OH  . TYR B 1 262 ? -60.27219 44.17053 -72.84303 1.000 58.23785  ? 260 TYR B OH  1 
ATOM   3901 N  N   . TRP B 1 263 ? -56.19278 46.47507 -77.50698 1.000 38.62129  ? 261 TRP B N   1 
ATOM   3902 C  CA  . TRP B 1 263 ? -57.31997 47.08947 -78.21805 1.000 45.83682  ? 261 TRP B CA  1 
ATOM   3903 C  C   . TRP B 1 263 ? -57.37331 46.67152 -79.68494 1.000 43.97522  ? 261 TRP B C   1 
ATOM   3904 O  O   . TRP B 1 263 ? -58.46000 46.46389 -80.22817 1.000 48.56667  ? 261 TRP B O   1 
ATOM   3905 C  CB  . TRP B 1 263 ? -57.25627 48.61058 -78.10062 1.000 38.98013  ? 261 TRP B CB  1 
ATOM   3906 C  CG  . TRP B 1 263 ? -57.65716 49.07448 -76.73433 1.000 42.70825  ? 261 TRP B CG  1 
ATOM   3907 C  CD1 . TRP B 1 263 ? -56.86748 49.69765 -75.80943 1.000 43.30800  ? 261 TRP B CD1 1 
ATOM   3908 C  CD2 . TRP B 1 263 ? -58.95407 48.94330 -76.13415 1.000 46.85324  ? 261 TRP B CD2 1 
ATOM   3909 N  NE1 . TRP B 1 263 ? -57.59182 49.96305 -74.66692 1.000 48.61225  ? 261 TRP B NE1 1 
ATOM   3910 C  CE2 . TRP B 1 263 ? -58.87468 49.50824 -74.83952 1.000 53.54224  ? 261 TRP B CE2 1 
ATOM   3911 C  CE3 . TRP B 1 263 ? -60.17474 48.40214 -76.56528 1.000 42.80685  ? 261 TRP B CE3 1 
ATOM   3912 C  CZ2 . TRP B 1 263 ? -59.97231 49.54818 -73.97270 1.000 44.94205  ? 261 TRP B CZ2 1 
ATOM   3913 C  CZ3 . TRP B 1 263 ? -61.25566 48.43555 -75.71333 1.000 44.63271  ? 261 TRP B CZ3 1 
ATOM   3914 C  CH2 . TRP B 1 263 ? -61.15011 49.00776 -74.42565 1.000 49.11365  ? 261 TRP B CH2 1 
ATOM   3915 N  N   . LEU B 1 264 ? -56.22034 46.52768 -80.34131 1.000 43.07450  ? 262 LEU B N   1 
ATOM   3916 C  CA  . LEU B 1 264 ? -56.21726 46.13712 -81.74807 1.000 43.20054  ? 262 LEU B CA  1 
ATOM   3917 C  C   . LEU B 1 264 ? -56.52149 44.66328 -81.96718 1.000 48.24107  ? 262 LEU B C   1 
ATOM   3918 O  O   . LEU B 1 264 ? -57.16149 44.32103 -82.96459 1.000 51.78561  ? 262 LEU B O   1 
ATOM   3919 C  CB  . LEU B 1 264 ? -54.87492 46.47482 -82.38711 1.000 42.30610  ? 262 LEU B CB  1 
ATOM   3920 C  CG  . LEU B 1 264 ? -54.63648 47.98205 -82.40709 1.000 45.20269  ? 262 LEU B CG  1 
ATOM   3921 C  CD1 . LEU B 1 264 ? -53.15335 48.30008 -82.50455 1.000 48.22989  ? 262 LEU B CD1 1 
ATOM   3922 C  CD2 . LEU B 1 264 ? -55.42215 48.59333 -83.57562 1.000 49.99185  ? 262 LEU B CD2 1 
ATOM   3923 N  N   . LEU B 1 265 ? -56.08215 43.77066 -81.07959 1.000 52.03283  ? 263 LEU B N   1 
ATOM   3924 C  CA  . LEU B 1 265 ? -56.18933 42.34334 -81.35691 1.000 45.65971  ? 263 LEU B CA  1 
ATOM   3925 C  C   . LEU B 1 265 ? -57.20700 41.60597 -80.50887 1.000 48.46504  ? 263 LEU B C   1 
ATOM   3926 O  O   . LEU B 1 265 ? -57.53110 40.46183 -80.84305 1.000 56.17133  ? 263 LEU B O   1 
ATOM   3927 C  CB  . LEU B 1 265 ? -54.83035 41.66914 -81.18204 1.000 46.85718  ? 263 LEU B CB  1 
ATOM   3928 C  CG  . LEU B 1 265 ? -53.73719 42.38642 -81.96489 1.000 56.38462  ? 263 LEU B CG  1 
ATOM   3929 C  CD1 . LEU B 1 265 ? -52.39173 41.81102 -81.62044 1.000 53.20238  ? 263 LEU B CD1 1 
ATOM   3930 C  CD2 . LEU B 1 265 ? -54.01259 42.22251 -83.43036 1.000 53.76786  ? 263 LEU B CD2 1 
ATOM   3931 N  N   . GLY B 1 266 ? -57.72777 42.21947 -79.42330 1.000 56.22792  ? 264 GLY B N   1 
ATOM   3932 C  CA  . GLY B 1 266 ? -58.58278 41.49901 -78.49878 1.000 60.86328  ? 264 GLY B CA  1 
ATOM   3933 C  C   . GLY B 1 266 ? -60.05585 41.43753 -78.91665 1.000 65.17135  ? 264 GLY B C   1 
ATOM   3934 O  O   . GLY B 1 266 ? -60.51431 42.14378 -79.81195 1.000 62.65114  ? 264 GLY B O   1 
ATOM   3935 N  N   . THR B 1 267 ? -60.80788 40.59478 -78.20328 1.000 76.87624  ? 265 THR B N   1 
ATOM   3936 C  CA  . THR B 1 267 ? -62.23771 40.37432 -78.45099 1.000 71.58143  ? 265 THR B CA  1 
ATOM   3937 C  C   . THR B 1 267 ? -63.03440 40.27319 -77.13503 1.000 76.97793  ? 265 THR B C   1 
ATOM   3938 O  O   . THR B 1 267 ? -63.54800 41.26645 -76.60805 1.000 81.30647  ? 265 THR B O   1 
ATOM   3939 C  CB  . THR B 1 267 ? -62.45103 39.07944 -79.27183 1.000 74.09018  ? 265 THR B CB  1 
ATOM   3940 O  OG1 . THR B 1 267 ? -62.01296 39.28481 -80.62381 1.000 69.50492  ? 265 THR B OG1 1 
ATOM   3941 C  CG2 . THR B 1 267 ? -63.91134 38.66705 -79.26328 1.000 73.05062  ? 265 THR B CG2 1 
HETATM 3942 C  CHA . HEM C 2 .   ? -10.68915 31.33490 -56.26152 1.000 49.12686  ? 301 HEM A CHA 1 
HETATM 3943 C  CHB . HEM C 2 .   ? -13.77933 34.92994 -55.18963 1.000 42.55390  ? 301 HEM A CHB 1 
HETATM 3944 C  CHC . HEM C 2 .   ? -14.78320 35.56521 -59.88062 1.000 44.65198  ? 301 HEM A CHC 1 
HETATM 3945 C  CHD . HEM C 2 .   ? -11.42096 32.14870 -60.99684 1.000 44.05671  ? 301 HEM A CHD 1 
HETATM 3946 C  C1A . HEM C 2 .   ? -11.50420 32.20898 -55.57675 1.000 46.64420  ? 301 HEM A C1A 1 
HETATM 3947 C  C2A . HEM C 2 .   ? -11.70145 32.25243 -54.13615 1.000 40.61674  ? 301 HEM A C2A 1 
HETATM 3948 C  C3A . HEM C 2 .   ? -12.55091 33.24606 -53.87546 1.000 42.70933  ? 301 HEM A C3A 1 
HETATM 3949 C  C4A . HEM C 2 .   ? -12.91219 33.86967 -55.11469 1.000 42.55521  ? 301 HEM A C4A 1 
HETATM 3950 C  CMA . HEM C 2 .   ? -13.08032 33.70257 -52.50227 1.000 40.98195  ? 301 HEM A CMA 1 
HETATM 3951 C  CAA . HEM C 2 .   ? -11.08233 31.31784 -53.07998 1.000 46.41540  ? 301 HEM A CAA 1 
HETATM 3952 C  CBA . HEM C 2 .   ? -11.95335 30.06363 -53.15732 1.000 59.06970  ? 301 HEM A CBA 1 
HETATM 3953 C  CGA . HEM C 2 .   ? -11.65000 29.08841 -52.05237 1.000 67.34500  ? 301 HEM A CGA 1 
HETATM 3954 O  O1A . HEM C 2 .   ? -12.45746 28.13439 -51.82153 1.000 72.82772  ? 301 HEM A O1A 1 
HETATM 3955 O  O2A . HEM C 2 .   ? -10.59733 29.28632 -51.40058 1.000 70.52695  ? 301 HEM A O2A 1 
HETATM 3956 C  C1B . HEM C 2 .   ? -14.35064 35.38603 -56.35587 1.000 43.27267  ? 301 HEM A C1B 1 
HETATM 3957 C  C2B . HEM C 2 .   ? -15.35917 36.40781 -56.43902 1.000 42.22532  ? 301 HEM A C2B 1 
HETATM 3958 C  C3B . HEM C 2 .   ? -15.66462 36.58836 -57.70829 1.000 45.40804  ? 301 HEM A C3B 1 
HETATM 3959 C  C4B . HEM C 2 .   ? -14.83317 35.70099 -58.51194 1.000 41.15626  ? 301 HEM A C4B 1 
HETATM 3960 C  CMB . HEM C 2 .   ? -16.04100 37.18673 -55.29675 1.000 34.23166  ? 301 HEM A CMB 1 
HETATM 3961 C  CAB . HEM C 2 .   ? -16.73557 37.64561 -58.06320 1.000 46.60192  ? 301 HEM A CAB 1 
HETATM 3962 C  CBB . HEM C 2 .   ? -17.42581 37.60257 -59.18215 1.000 52.39229  ? 301 HEM A CBB 1 
HETATM 3963 C  C1C . HEM C 2 .   ? -13.90787 34.74540 -60.57514 1.000 50.21580  ? 301 HEM A C1C 1 
HETATM 3964 C  C2C . HEM C 2 .   ? -13.76203 34.70714 -62.02225 1.000 49.31606  ? 301 HEM A C2C 1 
HETATM 3965 C  C3C . HEM C 2 .   ? -12.86413 33.77481 -62.32774 1.000 42.97339  ? 301 HEM A C3C 1 
HETATM 3966 C  C4C . HEM C 2 .   ? -12.36961 33.15867 -61.10431 1.000 53.13225  ? 301 HEM A C4C 1 
HETATM 3967 C  CMC . HEM C 2 .   ? -14.50327 35.56699 -63.08016 1.000 44.85427  ? 301 HEM A CMC 1 
HETATM 3968 C  CAC . HEM C 2 .   ? -12.48763 33.50960 -63.78842 1.000 54.05073  ? 301 HEM A CAC 1 
HETATM 3969 C  CBC . HEM C 2 .   ? -11.62344 32.57352 -64.13523 1.000 59.47183  ? 301 HEM A CBC 1 
HETATM 3970 C  C1D . HEM C 2 .   ? -10.93428 31.59455 -59.82321 1.000 50.10557  ? 301 HEM A C1D 1 
HETATM 3971 C  C2D . HEM C 2 .   ? -10.00205 30.48584 -59.66963 1.000 55.79658  ? 301 HEM A C2D 1 
HETATM 3972 C  C3D . HEM C 2 .   ? -9.80284  30.26725 -58.36571 1.000 53.40980  ? 301 HEM A C3D 1 
HETATM 3973 C  C4D . HEM C 2 .   ? -10.60099 31.22744 -57.63558 1.000 48.54273  ? 301 HEM A C4D 1 
HETATM 3974 C  CMD . HEM C 2 .   ? -9.33648  29.67496 -60.80784 1.000 55.52051  ? 301 HEM A CMD 1 
HETATM 3975 C  CAD . HEM C 2 .   ? -8.88567  29.17843 -57.74213 1.000 53.82249  ? 301 HEM A CAD 1 
HETATM 3976 C  CBD . HEM C 2 .   ? -7.57065  29.76519 -57.20363 1.000 62.50527  ? 301 HEM A CBD 1 
HETATM 3977 C  CGD . HEM C 2 .   ? -6.90053  30.65619 -58.23360 1.000 69.03489  ? 301 HEM A CGD 1 
HETATM 3978 O  O1D . HEM C 2 .   ? -6.55864  30.15148 -59.33510 1.000 79.18464  ? 301 HEM A O1D 1 
HETATM 3979 O  O2D . HEM C 2 .   ? -6.69468  31.87819 -57.97985 1.000 66.53099  ? 301 HEM A O2D 1 
HETATM 3980 N  NA  . HEM C 2 .   ? -12.26475 33.21738 -56.15525 1.000 41.50600  ? 301 HEM A NA  1 
HETATM 3981 N  NB  . HEM C 2 .   ? -14.04690 34.97407 -57.64306 1.000 41.87677  ? 301 HEM A NB  1 
HETATM 3982 N  NC  . HEM C 2 .   ? -13.04394 33.78394 -60.04706 1.000 47.49541  ? 301 HEM A NC  1 
HETATM 3983 N  ND  . HEM C 2 .   ? -11.27331 32.00759 -58.55033 1.000 53.82331  ? 301 HEM A ND  1 
HETATM 3984 FE FE  . HEM C 2 .   ? -12.85306 33.26867 -58.15379 1.000 42.41413  ? 301 HEM A FE  1 
HETATM 3985 O  OXT A 78U D 3 .   ? -7.07719  33.06129 -61.38057 0.560 63.38467  ? 302 78U A OXT 1 
HETATM 3986 O  OXT B 78U D 3 .   ? -6.90492  32.86785 -61.14911 0.100 62.29423  ? 302 78U A OXT 1 
HETATM 3987 C  C   A 78U D 3 .   ? -7.78609  33.82586 -62.10225 0.560 61.66504  ? 302 78U A C   1 
HETATM 3988 C  C   B 78U D 3 .   ? -7.72398  33.55197 -61.82151 0.100 61.08769  ? 302 78U A C   1 
HETATM 3989 O  O   A 78U D 3 .   ? -8.02494  33.51914 -63.30455 0.560 61.07580  ? 302 78U A O   1 
HETATM 3990 O  O   B 78U D 3 .   ? -7.71106  33.47328 -63.07947 0.100 61.16113  ? 302 78U A O   1 
HETATM 3991 C  CA  A 78U D 3 .   ? -8.34521  35.14476 -61.55769 0.560 58.80617  ? 302 78U A CA  1 
HETATM 3992 C  CA  B 78U D 3 .   ? -8.71797  34.46250 -61.09226 0.100 57.70743  ? 302 78U A CA  1 
HETATM 3993 N  N   A 78U D 3 .   ? -9.03293  35.83978 -62.65180 0.560 58.72728  ? 302 78U A N   1 
HETATM 3994 N  N   B 78U D 3 .   ? -8.26039  34.59954 -59.71772 0.100 56.36467  ? 302 78U A N   1 
HETATM 3995 C  CB  A 78U D 3 .   ? -9.30771  34.93672 -60.37749 0.560 59.01422  ? 302 78U A CB  1 
HETATM 3996 C  CB  B 78U D 3 .   ? -8.83818  35.82761 -61.78990 0.100 57.85783  ? 302 78U A CB  1 
HETATM 3997 C  CAG A 78U D 3 .   ? -8.69863  34.22994 -59.15980 0.560 54.03182  ? 302 78U A CAG 1 
HETATM 3998 C  CAG B 78U D 3 .   ? -9.78590  35.74647 -62.98875 0.100 56.14253  ? 302 78U A CAG 1 
HETATM 3999 C  CG  A 78U D 3 .   ? -9.70530  36.33168 -59.91449 0.560 59.25002  ? 302 78U A CG  1 
HETATM 4000 C  CG  B 78U D 3 .   ? -9.37168  36.93394 -60.87110 0.100 56.59523  ? 302 78U A CG  1 
HETATM 4001 C  CD2 A 78U D 3 .   ? -9.46871  37.67403 -59.87361 0.560 57.52159  ? 302 78U A CD2 1 
HETATM 4002 C  CD2 B 78U D 3 .   ? -9.27910  38.17945 -60.32248 0.100 56.28492  ? 302 78U A CD2 1 
HETATM 4003 C  CE3 A 78U D 3 .   ? -8.45575  38.47107 -60.43687 0.560 57.53434  ? 302 78U A CE3 1 
HETATM 4004 C  CE3 B 78U D 3 .   ? -8.31456  39.19289 -60.45393 0.100 56.41814  ? 302 78U A CE3 1 
HETATM 4005 C  CZ3 A 78U D 3 .   ? -8.44584  39.84204 -60.23752 0.560 55.91283  ? 302 78U A CZ3 1 
HETATM 4006 C  CZ3 B 78U D 3 .   ? -8.45671  40.38584 -59.76416 0.100 54.39386  ? 302 78U A CZ3 1 
HETATM 4007 C  CH2 A 78U D 3 .   ? -9.44293  40.42569 -59.48491 0.560 52.83770  ? 302 78U A CH2 1 
HETATM 4008 C  CH2 B 78U D 3 .   ? -9.55464  40.58086 -58.94451 0.100 53.19782  ? 302 78U A CH2 1 
HETATM 4009 C  CZ2 A 78U D 3 .   ? -10.44143 39.63734 -58.93392 0.560 54.45973  ? 302 78U A CZ2 1 
HETATM 4010 C  CZ2 B 78U D 3 .   ? -10.50765 39.58363 -58.81838 0.100 54.25348  ? 302 78U A CZ2 1 
HETATM 4011 C  CE2 A 78U D 3 .   ? -10.46205 38.23773 -59.12619 0.560 57.61403  ? 302 78U A CE2 1 
HETATM 4012 C  CE2 B 78U D 3 .   ? -10.36392 38.36999 -59.51373 0.100 55.94048  ? 302 78U A CE2 1 
HETATM 4013 N  NE1 A 78U D 3 .   ? -11.31974 37.22444 -58.70179 0.560 50.61502  ? 302 78U A NE1 1 
HETATM 4014 N  NE1 B 78U D 3 .   ? -11.14121 37.23574 -59.56789 0.100 53.15757  ? 302 78U A NE1 1 
HETATM 4015 C  CD1 A 78U D 3 .   ? -10.85084 36.04709 -59.18402 0.560 54.25694  ? 302 78U A CD1 1 
HETATM 4016 C  CD1 B 78U D 3 .   ? -10.53805 36.35684 -60.40860 0.100 55.07179  ? 302 78U A CD1 1 
HETATM 4017 C  CHA . HEM E 2 .   ? -37.68547 57.32094 -51.72146 1.000 51.59626  ? 301 HEM B CHA 1 
HETATM 4018 C  CHB . HEM E 2 .   ? -33.90904 54.38492 -52.52953 1.000 43.37158  ? 301 HEM B CHB 1 
HETATM 4019 C  CHC . HEM E 2 .   ? -34.56100 52.34110 -48.19474 1.000 43.02593  ? 301 HEM B CHC 1 
HETATM 4020 C  CHD . HEM E 2 .   ? -38.16579 55.49324 -47.26056 1.000 45.17022  ? 301 HEM B CHD 1 
HETATM 4021 C  C1A . HEM E 2 .   ? -36.66245 56.66172 -52.36584 1.000 46.67772  ? 301 HEM B C1A 1 
HETATM 4022 C  C2A . HEM E 2 .   ? -36.25841 56.81120 -53.74581 1.000 46.84734  ? 301 HEM B C2A 1 
HETATM 4023 C  C3A . HEM E 2 .   ? -35.22577 55.99183 -53.95144 1.000 52.80533  ? 301 HEM B C3A 1 
HETATM 4024 C  C4A . HEM E 2 .   ? -34.92659 55.30274 -52.71860 1.000 41.71100  ? 301 HEM B C4A 1 
HETATM 4025 C  CMA . HEM E 2 .   ? -34.46229 55.80701 -55.27938 1.000 39.69558  ? 301 HEM B CMA 1 
HETATM 4026 C  CAA . HEM E 2 .   ? -36.92235 57.68378 -54.82527 1.000 49.91761  ? 301 HEM B CAA 1 
HETATM 4027 C  CBA . HEM E 2 .   ? -38.12379 56.80507 -55.21636 1.000 63.67989  ? 301 HEM B CBA 1 
HETATM 4028 C  CGA . HEM E 2 .   ? -39.08318 57.27045 -56.30550 1.000 77.69501  ? 301 HEM B CGA 1 
HETATM 4029 O  O1A . HEM E 2 .   ? -38.98966 58.44052 -56.77191 1.000 79.18955  ? 301 HEM B O1A 1 
HETATM 4030 O  O2A . HEM E 2 .   ? -39.96273 56.43816 -56.70969 1.000 74.79379  ? 301 HEM B O2A 1 
HETATM 4031 C  C1B . HEM E 2 .   ? -33.75549 53.53714 -51.44928 1.000 45.05027  ? 301 HEM B C1B 1 
HETATM 4032 C  C2B . HEM E 2 .   ? -32.80587 52.44253 -51.33797 1.000 45.40314  ? 301 HEM B C2B 1 
HETATM 4033 C  C3B . HEM E 2 .   ? -33.00249 51.87820 -50.13085 1.000 41.44583  ? 301 HEM B C3B 1 
HETATM 4034 C  C4B . HEM E 2 .   ? -34.06931 52.59242 -49.46155 1.000 44.23278  ? 301 HEM B C4B 1 
HETATM 4035 C  CMB . HEM E 2 .   ? -31.77187 52.07328 -52.43960 1.000 32.19463  ? 301 HEM B CMB 1 
HETATM 4036 C  CAB . HEM E 2 .   ? -32.28341 50.67499 -49.46690 1.000 46.70045  ? 301 HEM B CAB 1 
HETATM 4037 C  CBB . HEM E 2 .   ? -31.57353 49.78426 -50.16406 1.000 47.69508  ? 301 HEM B CBB 1 
HETATM 4038 C  C1C . HEM E 2 .   ? -35.54977 53.05502 -47.54375 1.000 46.87902  ? 301 HEM B C1C 1 
HETATM 4039 C  C2C . HEM E 2 .   ? -35.97356 52.84473 -46.17447 1.000 50.73577  ? 301 HEM B C2C 1 
HETATM 4040 C  C3C . HEM E 2 .   ? -36.96660 53.72645 -45.93084 1.000 49.39467  ? 301 HEM B C3C 1 
HETATM 4041 C  C4C . HEM E 2 .   ? -37.21666 54.49630 -47.12817 1.000 49.56455  ? 301 HEM B C4C 1 
HETATM 4042 C  CMC . HEM E 2 .   ? -35.31761 51.78647 -45.23598 1.000 40.63703  ? 301 HEM B CMC 1 
HETATM 4043 C  CAC . HEM E 2 .   ? -37.79653 53.96681 -44.65256 1.000 53.15973  ? 301 HEM B CAC 1 
HETATM 4044 C  CBC . HEM E 2 .   ? -37.84330 53.08716 -43.65326 1.000 58.69945  ? 301 HEM B CBC 1 
HETATM 4045 C  C1D . HEM E 2 .   ? -38.38337 56.25844 -48.38865 1.000 50.76061  ? 301 HEM B C1D 1 
HETATM 4046 C  C2D . HEM E 2 .   ? -39.40630 57.27653 -48.57791 1.000 53.95548  ? 301 HEM B C2D 1 
HETATM 4047 C  C3D . HEM E 2 .   ? -39.25897 57.78614 -49.81241 1.000 46.36951  ? 301 HEM B C3D 1 
HETATM 4048 C  C4D . HEM E 2 .   ? -38.14338 57.10008 -50.43356 1.000 47.83856  ? 301 HEM B C4D 1 
HETATM 4049 C  CMD . HEM E 2 .   ? -40.45535 57.66490 -47.50431 1.000 51.05446  ? 301 HEM B CMD 1 
HETATM 4050 C  CAD . HEM E 2 .   ? -40.08897 58.87561 -50.55028 1.000 46.40398  ? 301 HEM B CAD 1 
HETATM 4051 C  CBD . HEM E 2 .   ? -40.21371 60.18604 -49.78918 1.000 69.35248  ? 301 HEM B CBD 1 
HETATM 4052 C  CGD . HEM E 2 .   ? -38.83371 60.65338 -49.45109 1.000 69.72578  ? 301 HEM B CGD 1 
HETATM 4053 O  O1D . HEM E 2 .   ? -38.04632 60.82439 -50.41657 1.000 74.97447  ? 301 HEM B O1D 1 
HETATM 4054 O  O2D . HEM E 2 .   ? -38.52937 60.85784 -48.24336 1.000 77.48744  ? 301 HEM B O2D 1 
HETATM 4055 N  NA  . HEM E 2 .   ? -35.82836 55.73876 -51.77853 1.000 44.30005  ? 301 HEM B NA  1 
HETATM 4056 N  NB  . HEM E 2 .   ? -34.50068 53.58833 -50.29181 1.000 42.69304  ? 301 HEM B NB  1 
HETATM 4057 N  NC  . HEM E 2 .   ? -36.32633 54.06107 -48.08745 1.000 47.79740  ? 301 HEM B NC  1 
HETATM 4058 N  ND  . HEM E 2 .   ? -37.63478 56.19049 -49.54084 1.000 48.78025  ? 301 HEM B ND  1 
HETATM 4059 FE FE  . HEM E 2 .   ? -36.26593 54.65115 -50.01954 1.000 40.94691  ? 301 HEM B FE  1 
HETATM 4060 O  OXT . 78U F 3 .   ? -37.78591 59.48309 -45.71058 0.750 68.59365  ? 302 78U B OXT 1 
HETATM 4061 C  C   . 78U F 3 .   ? -37.18805 58.61928 -44.99900 0.750 73.69158  ? 302 78U B C   1 
HETATM 4062 O  O   . 78U F 3 .   ? -37.80362 58.11261 -44.01983 0.750 71.44172  ? 302 78U B O   1 
HETATM 4063 C  CA  . 78U F 3 .   ? -35.72470 58.19423 -45.26118 0.750 76.73565  ? 302 78U B CA  1 
HETATM 4064 N  N   . 78U F 3 .   ? -35.29889 57.25575 -44.21804 0.750 69.57360  ? 302 78U B N   1 
HETATM 4065 C  CB  . 78U F 3 .   ? -35.52483 57.54668 -46.64542 0.750 70.85074  ? 302 78U B CB  1 
HETATM 4066 C  CAG . 78U F 3 .   ? -35.89757 58.46382 -47.82012 0.750 60.87503  ? 302 78U B CAG 1 
HETATM 4067 C  CG  . 78U F 3 .   ? -34.04084 57.20759 -46.82513 0.750 73.21390  ? 302 78U B CG  1 
HETATM 4068 C  CD2 . 78U F 3 .   ? -32.72061 57.36155 -46.49573 0.750 69.50670  ? 302 78U B CD2 1 
HETATM 4069 C  CE3 . 78U F 3 .   ? -32.06318 58.13851 -45.52608 0.750 74.41012  ? 302 78U B CE3 1 
HETATM 4070 C  CZ3 . 78U F 3 .   ? -30.68162 58.09265 -45.39668 0.750 70.72670  ? 302 78U B CZ3 1 
HETATM 4071 C  CH2 . 78U F 3 .   ? -29.92983 57.29275 -46.23125 0.750 59.57026  ? 302 78U B CH2 1 
HETATM 4072 C  CZ2 . 78U F 3 .   ? -30.58176 56.52819 -47.17988 0.750 61.99967  ? 302 78U B CZ2 1 
HETATM 4073 C  CE2 . 78U F 3 .   ? -31.98762 56.55706 -47.31801 0.750 61.86512  ? 302 78U B CE2 1 
HETATM 4074 N  NE1 . 78U F 3 .   ? -32.86236 55.90185 -48.16645 0.750 57.30123  ? 302 78U B NE1 1 
HETATM 4075 C  CD1 . 78U F 3 .   ? -34.12637 56.30573 -47.87690 0.750 62.58478  ? 302 78U B CD1 1 
HETATM 4076 O  O   . HOH G 4 .   ? -24.61330 56.61707 -60.31270 1.000 50.45442  ? 401 HOH A O   1 
HETATM 4077 O  O   . HOH G 4 .   ? -42.31619 22.55305 -36.38036 1.000 53.97610  ? 402 HOH A O   1 
HETATM 4078 O  O   . HOH G 4 .   ? -27.61701 59.94868 -67.35685 1.000 59.46206  ? 403 HOH A O   1 
HETATM 4079 O  O   . HOH G 4 .   ? -41.99165 16.39170 -28.06230 1.000 66.32205  ? 404 HOH A O   1 
HETATM 4080 O  O   . HOH G 4 .   ? -22.70072 39.25647 -72.33061 1.000 52.42673  ? 405 HOH A O   1 
HETATM 4081 O  O   . HOH G 4 .   ? -15.42514 27.63502 -56.07933 1.000 45.91656  ? 406 HOH A O   1 
HETATM 4082 O  O   . HOH G 4 .   ? -35.04032 15.57869 -26.67397 1.000 63.59110  ? 407 HOH A O   1 
HETATM 4083 O  O   . HOH G 4 .   ? -18.80682 42.46944 -74.33558 1.000 52.12832  ? 408 HOH A O   1 
HETATM 4084 O  O   . HOH G 4 .   ? -32.62820 21.40021 -35.12673 1.000 53.41882  ? 409 HOH A O   1 
HETATM 4085 O  O   . HOH G 4 .   ? -4.12802  38.47180 -55.03775 1.000 47.34164  ? 410 HOH A O   1 
HETATM 4086 O  O   . HOH G 4 .   ? -21.53936 30.42595 -25.99167 1.000 50.38737  ? 411 HOH A O   1 
HETATM 4087 O  O   . HOH G 4 .   ? -23.79644 49.10809 -37.15552 1.000 55.62332  ? 412 HOH A O   1 
HETATM 4088 O  O   . HOH G 4 .   ? -29.64706 38.68318 -60.71819 1.000 41.96677  ? 413 HOH A O   1 
HETATM 4089 O  O   . HOH G 4 .   ? -14.17269 23.17638 -43.02884 1.000 64.90373  ? 414 HOH A O   1 
HETATM 4090 O  O   . HOH G 4 .   ? -22.65305 29.95541 -61.55873 1.000 49.33726  ? 415 HOH A O   1 
HETATM 4091 O  O   . HOH G 4 .   ? -18.91656 46.51449 -67.95049 1.000 46.28962  ? 416 HOH A O   1 
HETATM 4092 O  O   . HOH G 4 .   ? -18.75080 37.37469 -26.50258 1.000 56.16340  ? 417 HOH A O   1 
HETATM 4093 O  O   . HOH G 4 .   ? -23.396   15.130   -43.547   1.000 66.18859  ? 418 HOH A O   1 
HETATM 4094 O  O   . HOH G 4 .   ? -15.00077 52.85867 -69.48125 1.000 68.16320  ? 419 HOH A O   1 
HETATM 4095 O  O   . HOH G 4 .   ? -19.91217 36.29374 -55.69794 1.000 40.66692  ? 420 HOH A O   1 
HETATM 4096 O  O   . HOH G 4 .   ? -35.01936 27.66834 -38.42246 1.000 53.99102  ? 421 HOH A O   1 
HETATM 4097 O  O   . HOH G 4 .   ? -21.44705 33.45373 -49.68729 1.000 36.58253  ? 422 HOH A O   1 
HETATM 4098 O  O   . HOH G 4 .   ? -34.61878 17.18604 -37.77919 1.000 51.45317  ? 423 HOH A O   1 
HETATM 4099 O  O   . HOH G 4 .   ? -17.60620 31.49059 -27.12855 1.000 57.74173  ? 424 HOH A O   1 
HETATM 4100 O  O   . HOH G 4 .   ? -24.60168 40.79744 -30.10614 1.000 47.42895  ? 425 HOH A O   1 
HETATM 4101 O  O   . HOH G 4 .   ? -27.71869 35.91714 -63.54409 1.000 55.83381  ? 426 HOH A O   1 
HETATM 4102 O  O   . HOH G 4 .   ? -17.10838 41.27524 -31.95588 1.000 62.11153  ? 427 HOH A O   1 
HETATM 4103 O  O   . HOH G 4 .   ? -24.26819 32.77023 -20.09001 1.000 69.89085  ? 428 HOH A O   1 
HETATM 4104 O  O   . HOH G 4 .   ? -16.30217 38.07595 -44.02632 1.000 45.04997  ? 429 HOH A O   1 
HETATM 4105 O  O   . HOH G 4 .   ? -41.16162 20.50147 -33.82699 1.000 60.21709  ? 430 HOH A O   1 
HETATM 4106 O  O   . HOH G 4 .   ? -27.88865 36.71232 -60.97822 1.000 44.35061  ? 431 HOH A O   1 
HETATM 4107 O  O   . HOH G 4 .   ? -14.15439 26.64775 -53.59924 1.000 58.94616  ? 432 HOH A O   1 
HETATM 4108 O  O   . HOH G 4 .   ? -41.79738 11.55570 -36.09100 1.000 69.41898  ? 433 HOH A O   1 
HETATM 4109 O  O   . HOH G 4 .   ? -32.68396 18.99601 -40.54066 1.000 57.24266  ? 434 HOH A O   1 
HETATM 4110 O  O   . HOH G 4 .   ? -18.30389 39.23443 -30.94166 1.000 56.13170  ? 435 HOH A O   1 
HETATM 4111 O  O   . HOH G 4 .   ? -32.62508 36.31389 -27.42597 1.000 55.29222  ? 436 HOH A O   1 
HETATM 4112 O  O   . HOH G 4 .   ? -26.72754 29.16801 -52.31213 1.000 47.89565  ? 437 HOH A O   1 
HETATM 4113 O  O   . HOH G 4 .   ? -16.36625 31.73059 -29.30717 1.000 53.50406  ? 438 HOH A O   1 
HETATM 4114 O  O   . HOH G 4 .   ? -33.46146 21.74270 -41.92125 1.000 55.83317  ? 439 HOH A O   1 
HETATM 4115 O  O   . HOH G 4 .   ? -33.45660 34.33373 -25.68663 1.000 62.71096  ? 440 HOH A O   1 
HETATM 4116 O  O   . HOH G 4 .   ? -35.40602 26.31910 -21.05116 1.000 63.46191  ? 441 HOH A O   1 
HETATM 4117 O  O   . HOH G 4 .   ? -16.37608 20.11602 -44.17674 1.000 67.77526  ? 442 HOH A O   1 
HETATM 4118 O  O   . HOH G 4 .   ? -25.14845 28.51370 -62.32592 1.000 55.48869  ? 443 HOH A O   1 
HETATM 4119 O  O   . HOH G 4 .   ? -25.28402 55.01996 -42.66482 1.000 59.82875  ? 444 HOH A O   1 
HETATM 4120 O  O   . HOH G 4 .   ? -24.14249 32.84285 -71.28868 1.000 57.00397  ? 445 HOH A O   1 
HETATM 4121 O  O   . HOH G 4 .   ? -7.07300  26.79528 -55.19562 1.000 77.22607  ? 446 HOH A O   1 
HETATM 4122 O  O   . HOH G 4 .   ? -17.62684 38.47831 -28.61196 1.000 63.06060  ? 447 HOH A O   1 
HETATM 4123 O  O   . HOH H 4 .   ? -14.87068 52.36427 -42.57644 1.000 67.40278  ? 401 HOH B O   1 
HETATM 4124 O  O   . HOH H 4 .   ? -20.29956 49.38457 -34.89333 1.000 71.41616  ? 402 HOH B O   1 
HETATM 4125 O  O   . HOH H 4 .   ? -44.26669 34.56458 -89.45202 1.000 55.08142  ? 403 HOH B O   1 
HETATM 4126 O  O   . HOH H 4 .   ? -13.81656 52.10716 -35.44556 1.000 68.69600  ? 404 HOH B O   1 
HETATM 4127 O  O   . HOH H 4 .   ? -41.29619 41.21320 -79.16480 1.000 46.16981  ? 405 HOH B O   1 
HETATM 4128 O  O   . HOH H 4 .   ? -30.39872 57.56628 -80.69219 1.000 54.78814  ? 406 HOH B O   1 
HETATM 4129 O  O   . HOH H 4 .   ? -32.36031 47.97507 -53.24862 1.000 39.94887  ? 407 HOH B O   1 
HETATM 4130 O  O   . HOH H 4 .   ? -30.82005 63.92023 -49.27926 1.000 61.02711  ? 408 HOH B O   1 
HETATM 4131 O  O   . HOH H 4 .   ? -46.128   38.947   -78.236   1.000 39.87282  ? 409 HOH B O   1 
HETATM 4132 O  O   . HOH H 4 .   ? -28.10516 37.63030 -73.40802 1.000 57.78835  ? 410 HOH B O   1 
HETATM 4133 O  O   . HOH H 4 .   ? -39.90850 44.34375 -50.03995 1.000 46.59278  ? 411 HOH B O   1 
HETATM 4134 O  O   . HOH H 4 .   ? -50.91538 32.79546 -82.85634 1.000 53.15569  ? 412 HOH B O   1 
HETATM 4135 O  O   . HOH H 4 .   ? -44.67259 41.01801 -89.31733 1.000 67.87007  ? 413 HOH B O   1 
HETATM 4136 O  O   . HOH H 4 .   ? -33.34881 39.28219 -50.47633 1.000 49.27620  ? 414 HOH B O   1 
HETATM 4137 O  O   . HOH H 4 .   ? -31.06518 37.36773 -50.48606 1.000 45.72766  ? 415 HOH B O   1 
HETATM 4138 O  O   . HOH H 4 .   ? -30.69769 54.10950 -83.07289 1.000 46.49021  ? 416 HOH B O   1 
HETATM 4139 O  O   . HOH H 4 .   ? -25.71720 45.94012 -39.11383 1.000 44.14871  ? 417 HOH B O   1 
HETATM 4140 O  O   . HOH H 4 .   ? -12.96700 55.27104 -49.05804 1.000 57.72450  ? 418 HOH B O   1 
HETATM 4141 O  O   . HOH H 4 .   ? -48.34031 50.05601 -80.81564 1.000 46.01813  ? 419 HOH B O   1 
HETATM 4142 O  O   . HOH H 4 .   ? -34.38674 38.79271 -47.87911 1.000 53.94195  ? 420 HOH B O   1 
HETATM 4143 O  O   . HOH H 4 .   ? -41.87877 33.55141 -82.87626 1.000 43.28152  ? 421 HOH B O   1 
HETATM 4144 O  O   . HOH H 4 .   ? -12.27680 37.39082 -38.60812 1.000 58.59863  ? 422 HOH B O   1 
HETATM 4145 O  O   . HOH H 4 .   ? -31.32043 44.45561 -33.81598 1.000 42.36792  ? 423 HOH B O   1 
HETATM 4146 O  O   . HOH H 4 .   ? -43.16363 58.74213 -72.82896 1.000 64.05545  ? 424 HOH B O   1 
HETATM 4147 O  O   . HOH H 4 .   ? -33.71441 48.26506 -60.03952 1.000 38.81816  ? 425 HOH B O   1 
HETATM 4148 O  O   . HOH H 4 .   ? -41.45551 41.92758 -50.43175 1.000 54.01703  ? 426 HOH B O   1 
HETATM 4149 O  O   . HOH H 4 .   ? -19.747   48.068   -76.019   1.000 51.80602  ? 427 HOH B O   1 
HETATM 4150 O  O   . HOH H 4 .   ? -44.62860 46.03368 -75.45152 1.000 41.42603  ? 428 HOH B O   1 
HETATM 4151 O  O   . HOH H 4 .   ? -32.86496 41.88087 -91.66995 1.000 54.16199  ? 429 HOH B O   1 
HETATM 4152 O  O   . HOH H 4 .   ? -41.39095 52.77253 -54.15954 1.000 46.12559  ? 430 HOH B O   1 
HETATM 4153 O  O   . HOH H 4 .   ? -54.63941 45.38458 -46.03366 1.000 52.10715  ? 431 HOH B O   1 
HETATM 4154 O  O   . HOH H 4 .   ? -15.38568 48.84214 -68.29731 1.000 54.62899  ? 432 HOH B O   1 
HETATM 4155 O  O   . HOH H 4 .   ? -24.25368 40.72977 -71.19292 1.000 59.56710  ? 433 HOH B O   1 
HETATM 4156 O  O   . HOH H 4 .   ? -41.07172 41.94265 -90.43643 1.000 51.02029  ? 434 HOH B O   1 
HETATM 4157 O  O   . HOH H 4 .   ? -49.800   48.633   -70.292   1.000 48.14974  ? 435 HOH B O   1 
HETATM 4158 O  O   . HOH H 4 .   ? -51.45864 30.26951 -86.51974 1.000 65.33339  ? 436 HOH B O   1 
HETATM 4159 O  O   . HOH H 4 .   ? -47.24918 49.77522 -83.55787 1.000 54.46432  ? 437 HOH B O   1 
HETATM 4160 O  O   . HOH H 4 .   ? -8.22587  50.80898 -52.92057 1.000 61.22767  ? 438 HOH B O   1 
HETATM 4161 O  O   . HOH H 4 .   ? -60.191   46.292   -82.657   1.000 64.76900  ? 439 HOH B O   1 
HETATM 4162 O  O   . HOH H 4 .   ? -25.18123 42.65654 -83.15243 1.000 54.89305  ? 440 HOH B O   1 
HETATM 4163 O  O   . HOH H 4 .   ? -43.136   26.183   -81.883   1.000 46.14388  ? 441 HOH B O   1 
HETATM 4164 O  O   . HOH H 4 .   ? -30.42771 58.43507 -78.20984 1.000 42.64363  ? 442 HOH B O   1 
HETATM 4165 O  O   . HOH H 4 .   ? -28.02130 56.56340 -85.46572 1.000 61.66168  ? 443 HOH B O   1 
HETATM 4166 O  O   . HOH H 4 .   ? -30.13810 55.27184 -32.84827 1.000 65.24950  ? 444 HOH B O   1 
HETATM 4167 O  O   . HOH H 4 .   ? -51.71639 34.46216 -84.88811 1.000 59.94906  ? 445 HOH B O   1 
# 
