data_8VPL
# 
_entry.id   8VPL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8VPL         pdb_00008vpl 10.2210/pdb8vpl/pdb 
WWPDB D_1000277603 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8VPL 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 xue.gao@rice.edu Xue  Gao ? 'principal investigator/group leader' 0000-0003-3213-9704 
4 yg60@rice.edu    Yang Gao ? 'principal investigator/group leader' 0000-0002-4037-0431 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Nie, Q.'   1 ? 
'Chang, C.' 2 ? 
'Gao, Y.'   3 ? 
'Gao, X.'   4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Glutaminyl cyclase ApgG, diamond shape' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nie, Q.'   1 ? 
primary 'Chang, C.' 2 ? 
primary 'Gao, Y.'   3 ? 
primary 'Gao, X.'   4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peptide hydrolase' 39133.613 1  3.4.-.- ? ? ? 
2 non-polymer syn 'ZINC ION'          65.409    1  ?       ? ? ? 
3 water       nat water               18.015    30 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDAHGNLSNADLEALLHPDGDTNIQTILAPLLRPRVPGTPGSELVRNYIIQFFNSALPLWTTELQVSSSKTPVSGSQRIP
FVNIIAYRSPPGLNETDVGWLTLVAHYDSLKDPEGFIGAIDSAAPCSIIMSAVRSIDAALTRKWDNMSSIPGDTHEQYGI
QVIFTDGEESFGNTLTANDGLYGSRSLAAHWAVDKYPSTAKYETRLSSISLLVLLDLLGAKNPQIASYYPVTHFDYQRLA
ALESRLRELGQLKSSGIHGKSWFVDRTTDVRSLKRQPVEDDQVPFSGLGVKVLHVIDADPTTGEFPSVWHTPDDDENHLD
FDTIRDWSLLITAFAAEWLGLQGFMDNHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDAHGNLSNADLEALLHPDGDTNIQTILAPLLRPRVPGTPGSELVRNYIIQFFNSALPLWTTELQVSSSKTPVSGSQRIP
FVNIIAYRSPPGLNETDVGWLTLVAHYDSLKDPEGFIGAIDSAAPCSIIMSAVRSIDAALTRKWDNMSSIPGDTHEQYGI
QVIFTDGEESFGNTLTANDGLYGSRSLAAHWAVDKYPSTAKYETRLSSISLLVLLDLLGAKNPQIASYYPVTHFDYQRLA
ALESRLRELGQLKSSGIHGKSWFVDRTTDVRSLKRQPVEDDQVPFSGLGVKVLHVIDADPTTGEFPSVWHTPDDDENHLD
FDTIRDWSLLITAFAAEWLGLQGFMDNHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION' ZN  
3 water      HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   ALA n 
1 4   HIS n 
1 5   GLY n 
1 6   ASN n 
1 7   LEU n 
1 8   SER n 
1 9   ASN n 
1 10  ALA n 
1 11  ASP n 
1 12  LEU n 
1 13  GLU n 
1 14  ALA n 
1 15  LEU n 
1 16  LEU n 
1 17  HIS n 
1 18  PRO n 
1 19  ASP n 
1 20  GLY n 
1 21  ASP n 
1 22  THR n 
1 23  ASN n 
1 24  ILE n 
1 25  GLN n 
1 26  THR n 
1 27  ILE n 
1 28  LEU n 
1 29  ALA n 
1 30  PRO n 
1 31  LEU n 
1 32  LEU n 
1 33  ARG n 
1 34  PRO n 
1 35  ARG n 
1 36  VAL n 
1 37  PRO n 
1 38  GLY n 
1 39  THR n 
1 40  PRO n 
1 41  GLY n 
1 42  SER n 
1 43  GLU n 
1 44  LEU n 
1 45  VAL n 
1 46  ARG n 
1 47  ASN n 
1 48  TYR n 
1 49  ILE n 
1 50  ILE n 
1 51  GLN n 
1 52  PHE n 
1 53  PHE n 
1 54  ASN n 
1 55  SER n 
1 56  ALA n 
1 57  LEU n 
1 58  PRO n 
1 59  LEU n 
1 60  TRP n 
1 61  THR n 
1 62  THR n 
1 63  GLU n 
1 64  LEU n 
1 65  GLN n 
1 66  VAL n 
1 67  SER n 
1 68  SER n 
1 69  SER n 
1 70  LYS n 
1 71  THR n 
1 72  PRO n 
1 73  VAL n 
1 74  SER n 
1 75  GLY n 
1 76  SER n 
1 77  GLN n 
1 78  ARG n 
1 79  ILE n 
1 80  PRO n 
1 81  PHE n 
1 82  VAL n 
1 83  ASN n 
1 84  ILE n 
1 85  ILE n 
1 86  ALA n 
1 87  TYR n 
1 88  ARG n 
1 89  SER n 
1 90  PRO n 
1 91  PRO n 
1 92  GLY n 
1 93  LEU n 
1 94  ASN n 
1 95  GLU n 
1 96  THR n 
1 97  ASP n 
1 98  VAL n 
1 99  GLY n 
1 100 TRP n 
1 101 LEU n 
1 102 THR n 
1 103 LEU n 
1 104 VAL n 
1 105 ALA n 
1 106 HIS n 
1 107 TYR n 
1 108 ASP n 
1 109 SER n 
1 110 LEU n 
1 111 LYS n 
1 112 ASP n 
1 113 PRO n 
1 114 GLU n 
1 115 GLY n 
1 116 PHE n 
1 117 ILE n 
1 118 GLY n 
1 119 ALA n 
1 120 ILE n 
1 121 ASP n 
1 122 SER n 
1 123 ALA n 
1 124 ALA n 
1 125 PRO n 
1 126 CYS n 
1 127 SER n 
1 128 ILE n 
1 129 ILE n 
1 130 MET n 
1 131 SER n 
1 132 ALA n 
1 133 VAL n 
1 134 ARG n 
1 135 SER n 
1 136 ILE n 
1 137 ASP n 
1 138 ALA n 
1 139 ALA n 
1 140 LEU n 
1 141 THR n 
1 142 ARG n 
1 143 LYS n 
1 144 TRP n 
1 145 ASP n 
1 146 ASN n 
1 147 MET n 
1 148 SER n 
1 149 SER n 
1 150 ILE n 
1 151 PRO n 
1 152 GLY n 
1 153 ASP n 
1 154 THR n 
1 155 HIS n 
1 156 GLU n 
1 157 GLN n 
1 158 TYR n 
1 159 GLY n 
1 160 ILE n 
1 161 GLN n 
1 162 VAL n 
1 163 ILE n 
1 164 PHE n 
1 165 THR n 
1 166 ASP n 
1 167 GLY n 
1 168 GLU n 
1 169 GLU n 
1 170 SER n 
1 171 PHE n 
1 172 GLY n 
1 173 ASN n 
1 174 THR n 
1 175 LEU n 
1 176 THR n 
1 177 ALA n 
1 178 ASN n 
1 179 ASP n 
1 180 GLY n 
1 181 LEU n 
1 182 TYR n 
1 183 GLY n 
1 184 SER n 
1 185 ARG n 
1 186 SER n 
1 187 LEU n 
1 188 ALA n 
1 189 ALA n 
1 190 HIS n 
1 191 TRP n 
1 192 ALA n 
1 193 VAL n 
1 194 ASP n 
1 195 LYS n 
1 196 TYR n 
1 197 PRO n 
1 198 SER n 
1 199 THR n 
1 200 ALA n 
1 201 LYS n 
1 202 TYR n 
1 203 GLU n 
1 204 THR n 
1 205 ARG n 
1 206 LEU n 
1 207 SER n 
1 208 SER n 
1 209 ILE n 
1 210 SER n 
1 211 LEU n 
1 212 LEU n 
1 213 VAL n 
1 214 LEU n 
1 215 LEU n 
1 216 ASP n 
1 217 LEU n 
1 218 LEU n 
1 219 GLY n 
1 220 ALA n 
1 221 LYS n 
1 222 ASN n 
1 223 PRO n 
1 224 GLN n 
1 225 ILE n 
1 226 ALA n 
1 227 SER n 
1 228 TYR n 
1 229 TYR n 
1 230 PRO n 
1 231 VAL n 
1 232 THR n 
1 233 HIS n 
1 234 PHE n 
1 235 ASP n 
1 236 TYR n 
1 237 GLN n 
1 238 ARG n 
1 239 LEU n 
1 240 ALA n 
1 241 ALA n 
1 242 LEU n 
1 243 GLU n 
1 244 SER n 
1 245 ARG n 
1 246 LEU n 
1 247 ARG n 
1 248 GLU n 
1 249 LEU n 
1 250 GLY n 
1 251 GLN n 
1 252 LEU n 
1 253 LYS n 
1 254 SER n 
1 255 SER n 
1 256 GLY n 
1 257 ILE n 
1 258 HIS n 
1 259 GLY n 
1 260 LYS n 
1 261 SER n 
1 262 TRP n 
1 263 PHE n 
1 264 VAL n 
1 265 ASP n 
1 266 ARG n 
1 267 THR n 
1 268 THR n 
1 269 ASP n 
1 270 VAL n 
1 271 ARG n 
1 272 SER n 
1 273 LEU n 
1 274 LYS n 
1 275 ARG n 
1 276 GLN n 
1 277 PRO n 
1 278 VAL n 
1 279 GLU n 
1 280 ASP n 
1 281 ASP n 
1 282 GLN n 
1 283 VAL n 
1 284 PRO n 
1 285 PHE n 
1 286 SER n 
1 287 GLY n 
1 288 LEU n 
1 289 GLY n 
1 290 VAL n 
1 291 LYS n 
1 292 VAL n 
1 293 LEU n 
1 294 HIS n 
1 295 VAL n 
1 296 ILE n 
1 297 ASP n 
1 298 ALA n 
1 299 ASP n 
1 300 PRO n 
1 301 THR n 
1 302 THR n 
1 303 GLY n 
1 304 GLU n 
1 305 PHE n 
1 306 PRO n 
1 307 SER n 
1 308 VAL n 
1 309 TRP n 
1 310 HIS n 
1 311 THR n 
1 312 PRO n 
1 313 ASP n 
1 314 ASP n 
1 315 ASP n 
1 316 GLU n 
1 317 ASN n 
1 318 HIS n 
1 319 LEU n 
1 320 ASP n 
1 321 PHE n 
1 322 ASP n 
1 323 THR n 
1 324 ILE n 
1 325 ARG n 
1 326 ASP n 
1 327 TRP n 
1 328 SER n 
1 329 LEU n 
1 330 LEU n 
1 331 ILE n 
1 332 THR n 
1 333 ALA n 
1 334 PHE n 
1 335 ALA n 
1 336 ALA n 
1 337 GLU n 
1 338 TRP n 
1 339 LEU n 
1 340 GLY n 
1 341 LEU n 
1 342 GLN n 
1 343 GLY n 
1 344 PHE n 
1 345 MET n 
1 346 ASP n 
1 347 ASN n 
1 348 HIS n 
1 349 HIS n 
1 350 HIS n 
1 351 HIS n 
1 352 HIS n 
1 353 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   354 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 F9C07_6934 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Aspergillus flavus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     5059 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   ALA 3   3   3   ALA ALA A . n 
A 1 4   HIS 4   4   4   HIS HIS A . n 
A 1 5   GLY 5   5   5   GLY GLY A . n 
A 1 6   ASN 6   6   6   ASN ASN A . n 
A 1 7   LEU 7   7   7   LEU LEU A . n 
A 1 8   SER 8   8   8   SER SER A . n 
A 1 9   ASN 9   9   9   ASN ASN A . n 
A 1 10  ALA 10  10  10  ALA ALA A . n 
A 1 11  ASP 11  11  11  ASP ASP A . n 
A 1 12  LEU 12  12  12  LEU LEU A . n 
A 1 13  GLU 13  13  13  GLU GLU A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  HIS 17  17  17  HIS HIS A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  ASP 19  19  19  ASP ASP A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  THR 22  22  22  THR THR A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  ILE 24  24  24  ILE ILE A . n 
A 1 25  GLN 25  25  25  GLN GLN A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  ILE 27  27  27  ILE ILE A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  ALA 29  29  29  ALA ALA A . n 
A 1 30  PRO 30  30  30  PRO PRO A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ARG 33  33  33  ARG ARG A . n 
A 1 34  PRO 34  34  34  PRO PRO A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  PRO 37  37  37  PRO PRO A . n 
A 1 38  GLY 38  38  38  GLY GLY A . n 
A 1 39  THR 39  39  39  THR THR A . n 
A 1 40  PRO 40  40  40  PRO PRO A . n 
A 1 41  GLY 41  41  41  GLY GLY A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  LEU 44  44  44  LEU LEU A . n 
A 1 45  VAL 45  45  45  VAL VAL A . n 
A 1 46  ARG 46  46  46  ARG ARG A . n 
A 1 47  ASN 47  47  47  ASN ASN A . n 
A 1 48  TYR 48  48  48  TYR TYR A . n 
A 1 49  ILE 49  49  49  ILE ILE A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  GLN 51  51  51  GLN GLN A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  PHE 53  53  53  PHE PHE A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  SER 55  55  55  SER SER A . n 
A 1 56  ALA 56  56  56  ALA ALA A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  PRO 58  58  58  PRO PRO A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  TRP 60  60  60  TRP TRP A . n 
A 1 61  THR 61  61  61  THR THR A . n 
A 1 62  THR 62  62  62  THR THR A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  GLN 65  65  65  GLN GLN A . n 
A 1 66  VAL 66  66  66  VAL VAL A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  SER 68  68  68  SER SER A . n 
A 1 69  SER 69  69  69  SER SER A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  THR 71  71  71  THR THR A . n 
A 1 72  PRO 72  72  72  PRO PRO A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  SER 74  74  74  SER SER A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  GLN 77  77  77  GLN GLN A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  PRO 80  80  80  PRO PRO A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  VAL 82  82  82  VAL VAL A . n 
A 1 83  ASN 83  83  83  ASN ASN A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  ALA 86  86  86  ALA ALA A . n 
A 1 87  TYR 87  87  87  TYR TYR A . n 
A 1 88  ARG 88  88  88  ARG ARG A . n 
A 1 89  SER 89  89  89  SER SER A . n 
A 1 90  PRO 90  90  90  PRO PRO A . n 
A 1 91  PRO 91  91  91  PRO PRO A . n 
A 1 92  GLY 92  92  92  GLY GLY A . n 
A 1 93  LEU 93  93  93  LEU LEU A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  THR 96  96  96  THR THR A . n 
A 1 97  ASP 97  97  97  ASP ASP A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  GLY 99  99  99  GLY GLY A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 LEU 101 101 101 LEU LEU A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 HIS 106 106 106 HIS HIS A . n 
A 1 107 TYR 107 107 107 TYR TYR A . n 
A 1 108 ASP 108 108 108 ASP ASP A . n 
A 1 109 SER 109 109 109 SER SER A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 PRO 113 113 113 PRO PRO A . n 
A 1 114 GLU 114 114 114 GLU GLU A . n 
A 1 115 GLY 115 115 115 GLY GLY A . n 
A 1 116 PHE 116 116 116 PHE PHE A . n 
A 1 117 ILE 117 117 117 ILE ILE A . n 
A 1 118 GLY 118 118 118 GLY GLY A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 SER 122 122 122 SER SER A . n 
A 1 123 ALA 123 123 123 ALA ALA A . n 
A 1 124 ALA 124 124 124 ALA ALA A . n 
A 1 125 PRO 125 125 125 PRO PRO A . n 
A 1 126 CYS 126 126 126 CYS CYS A . n 
A 1 127 SER 127 127 127 SER SER A . n 
A 1 128 ILE 128 128 128 ILE ILE A . n 
A 1 129 ILE 129 129 129 ILE ILE A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 SER 131 131 131 SER SER A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 SER 135 135 135 SER SER A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 ASP 137 137 137 ASP ASP A . n 
A 1 138 ALA 138 138 138 ALA ALA A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 ARG 142 142 142 ARG ARG A . n 
A 1 143 LYS 143 143 143 LYS LYS A . n 
A 1 144 TRP 144 144 144 TRP TRP A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 SER 148 148 ?   ?   ?   A . n 
A 1 149 SER 149 149 ?   ?   ?   A . n 
A 1 150 ILE 150 150 ?   ?   ?   A . n 
A 1 151 PRO 151 151 ?   ?   ?   A . n 
A 1 152 GLY 152 152 ?   ?   ?   A . n 
A 1 153 ASP 153 153 ?   ?   ?   A . n 
A 1 154 THR 154 154 ?   ?   ?   A . n 
A 1 155 HIS 155 155 ?   ?   ?   A . n 
A 1 156 GLU 156 156 156 GLU GLU A . n 
A 1 157 GLN 157 157 157 GLN GLN A . n 
A 1 158 TYR 158 158 158 TYR TYR A . n 
A 1 159 GLY 159 159 159 GLY GLY A . n 
A 1 160 ILE 160 160 160 ILE ILE A . n 
A 1 161 GLN 161 161 161 GLN GLN A . n 
A 1 162 VAL 162 162 162 VAL VAL A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 PHE 164 164 164 PHE PHE A . n 
A 1 165 THR 165 165 165 THR THR A . n 
A 1 166 ASP 166 166 166 ASP ASP A . n 
A 1 167 GLY 167 167 167 GLY GLY A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 GLU 169 169 169 GLU GLU A . n 
A 1 170 SER 170 170 170 SER SER A . n 
A 1 171 PHE 171 171 171 PHE PHE A . n 
A 1 172 GLY 172 172 172 GLY GLY A . n 
A 1 173 ASN 173 173 173 ASN ASN A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 THR 176 176 176 THR THR A . n 
A 1 177 ALA 177 177 177 ALA ALA A . n 
A 1 178 ASN 178 178 178 ASN ASN A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 GLY 180 180 180 GLY GLY A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 SER 184 184 184 SER SER A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 LEU 187 187 187 LEU LEU A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 ALA 189 189 189 ALA ALA A . n 
A 1 190 HIS 190 190 190 HIS HIS A . n 
A 1 191 TRP 191 191 191 TRP TRP A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 VAL 193 193 193 VAL VAL A . n 
A 1 194 ASP 194 194 194 ASP ASP A . n 
A 1 195 LYS 195 195 195 LYS LYS A . n 
A 1 196 TYR 196 196 196 TYR TYR A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 SER 198 198 198 SER SER A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ALA 200 200 200 ALA ALA A . n 
A 1 201 LYS 201 201 201 LYS LYS A . n 
A 1 202 TYR 202 202 202 TYR TYR A . n 
A 1 203 GLU 203 203 203 GLU GLU A . n 
A 1 204 THR 204 204 204 THR THR A . n 
A 1 205 ARG 205 205 205 ARG ARG A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 SER 207 207 207 SER SER A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 SER 210 210 210 SER SER A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 VAL 213 213 213 VAL VAL A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 LEU 218 218 218 LEU LEU A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 LYS 221 221 221 LYS LYS A . n 
A 1 222 ASN 222 222 222 ASN ASN A . n 
A 1 223 PRO 223 223 223 PRO PRO A . n 
A 1 224 GLN 224 224 224 GLN GLN A . n 
A 1 225 ILE 225 225 225 ILE ILE A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 TYR 228 228 228 TYR TYR A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 PRO 230 230 230 PRO PRO A . n 
A 1 231 VAL 231 231 231 VAL VAL A . n 
A 1 232 THR 232 232 232 THR THR A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 PHE 234 234 234 PHE PHE A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 TYR 236 236 236 TYR TYR A . n 
A 1 237 GLN 237 237 237 GLN GLN A . n 
A 1 238 ARG 238 238 238 ARG ARG A . n 
A 1 239 LEU 239 239 239 LEU LEU A . n 
A 1 240 ALA 240 240 240 ALA ALA A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 SER 244 244 244 SER SER A . n 
A 1 245 ARG 245 245 245 ARG ARG A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 ARG 247 247 247 ARG ARG A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 GLY 250 250 250 GLY GLY A . n 
A 1 251 GLN 251 251 251 GLN GLN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 LYS 253 253 253 LYS LYS A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 GLY 256 256 256 GLY GLY A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 HIS 258 258 258 HIS HIS A . n 
A 1 259 GLY 259 259 259 GLY GLY A . n 
A 1 260 LYS 260 260 260 LYS LYS A . n 
A 1 261 SER 261 261 261 SER SER A . n 
A 1 262 TRP 262 262 262 TRP TRP A . n 
A 1 263 PHE 263 263 263 PHE PHE A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 ASP 265 265 265 ASP ASP A . n 
A 1 266 ARG 266 266 266 ARG ARG A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 ASP 269 269 269 ASP ASP A . n 
A 1 270 VAL 270 270 270 VAL VAL A . n 
A 1 271 ARG 271 271 271 ARG ARG A . n 
A 1 272 SER 272 272 272 SER SER A . n 
A 1 273 LEU 273 273 273 LEU LEU A . n 
A 1 274 LYS 274 274 274 LYS LYS A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 GLN 276 276 276 GLN GLN A . n 
A 1 277 PRO 277 277 277 PRO PRO A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 GLU 279 279 279 GLU GLU A . n 
A 1 280 ASP 280 280 280 ASP ASP A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 GLN 282 282 282 GLN GLN A . n 
A 1 283 VAL 283 283 283 VAL VAL A . n 
A 1 284 PRO 284 284 284 PRO PRO A . n 
A 1 285 PHE 285 285 285 PHE PHE A . n 
A 1 286 SER 286 286 286 SER SER A . n 
A 1 287 GLY 287 287 287 GLY GLY A . n 
A 1 288 LEU 288 288 288 LEU LEU A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 VAL 290 290 290 VAL VAL A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 LEU 293 293 293 LEU LEU A . n 
A 1 294 HIS 294 294 294 HIS HIS A . n 
A 1 295 VAL 295 295 295 VAL VAL A . n 
A 1 296 ILE 296 296 296 ILE ILE A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 ALA 298 298 298 ALA ALA A . n 
A 1 299 ASP 299 299 299 ASP ASP A . n 
A 1 300 PRO 300 300 300 PRO PRO A . n 
A 1 301 THR 301 301 301 THR THR A . n 
A 1 302 THR 302 302 302 THR THR A . n 
A 1 303 GLY 303 303 303 GLY GLY A . n 
A 1 304 GLU 304 304 304 GLU GLU A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
A 1 306 PRO 306 306 306 PRO PRO A . n 
A 1 307 SER 307 307 307 SER SER A . n 
A 1 308 VAL 308 308 308 VAL VAL A . n 
A 1 309 TRP 309 309 309 TRP TRP A . n 
A 1 310 HIS 310 310 310 HIS HIS A . n 
A 1 311 THR 311 311 311 THR THR A . n 
A 1 312 PRO 312 312 312 PRO PRO A . n 
A 1 313 ASP 313 313 313 ASP ASP A . n 
A 1 314 ASP 314 314 314 ASP ASP A . n 
A 1 315 ASP 315 315 315 ASP ASP A . n 
A 1 316 GLU 316 316 316 GLU GLU A . n 
A 1 317 ASN 317 317 317 ASN ASN A . n 
A 1 318 HIS 318 318 318 HIS HIS A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 ASP 320 320 320 ASP ASP A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 ASP 322 322 322 ASP ASP A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 ILE 324 324 324 ILE ILE A . n 
A 1 325 ARG 325 325 325 ARG ARG A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 TRP 327 327 327 TRP TRP A . n 
A 1 328 SER 328 328 328 SER SER A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 ILE 331 331 331 ILE ILE A . n 
A 1 332 THR 332 332 332 THR THR A . n 
A 1 333 ALA 333 333 333 ALA ALA A . n 
A 1 334 PHE 334 334 334 PHE PHE A . n 
A 1 335 ALA 335 335 335 ALA ALA A . n 
A 1 336 ALA 336 336 336 ALA ALA A . n 
A 1 337 GLU 337 337 337 GLU GLU A . n 
A 1 338 TRP 338 338 338 TRP TRP A . n 
A 1 339 LEU 339 339 339 LEU LEU A . n 
A 1 340 GLY 340 340 340 GLY GLY A . n 
A 1 341 LEU 341 341 341 LEU LEU A . n 
A 1 342 GLN 342 342 342 GLN GLN A . n 
A 1 343 GLY 343 343 343 GLY GLY A . n 
A 1 344 PHE 344 344 344 PHE PHE A . n 
A 1 345 MET 345 345 345 MET MET A . n 
A 1 346 ASP 346 346 346 ASP ASP A . n 
A 1 347 ASN 347 347 347 ASN ASN A . n 
A 1 348 HIS 348 348 348 HIS HIS A . n 
A 1 349 HIS 349 349 349 HIS HIS A . n 
A 1 350 HIS 350 350 350 HIS HIS A . n 
A 1 351 HIS 351 351 351 HIS HIS A . n 
A 1 352 HIS 352 352 352 HIS HIS A . n 
A 1 353 HIS 353 353 353 HIS HIS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1  401 1  ZN  ZN  A . 
C 3 HOH 1  501 5  HOH HOH A . 
C 3 HOH 2  502 25 HOH HOH A . 
C 3 HOH 3  503 13 HOH HOH A . 
C 3 HOH 4  504 16 HOH HOH A . 
C 3 HOH 5  505 11 HOH HOH A . 
C 3 HOH 6  506 20 HOH HOH A . 
C 3 HOH 7  507 21 HOH HOH A . 
C 3 HOH 8  508 3  HOH HOH A . 
C 3 HOH 9  509 30 HOH HOH A . 
C 3 HOH 10 510 1  HOH HOH A . 
C 3 HOH 11 511 9  HOH HOH A . 
C 3 HOH 12 512 17 HOH HOH A . 
C 3 HOH 13 513 7  HOH HOH A . 
C 3 HOH 14 514 8  HOH HOH A . 
C 3 HOH 15 515 24 HOH HOH A . 
C 3 HOH 16 516 2  HOH HOH A . 
C 3 HOH 17 517 18 HOH HOH A . 
C 3 HOH 18 518 14 HOH HOH A . 
C 3 HOH 19 519 4  HOH HOH A . 
C 3 HOH 20 520 23 HOH HOH A . 
C 3 HOH 21 521 29 HOH HOH A . 
C 3 HOH 22 522 22 HOH HOH A . 
C 3 HOH 23 523 19 HOH HOH A . 
C 3 HOH 24 524 6  HOH HOH A . 
C 3 HOH 25 525 15 HOH HOH A . 
C 3 HOH 26 526 12 HOH HOH A . 
C 3 HOH 27 527 26 HOH HOH A . 
C 3 HOH 28 528 28 HOH HOH A . 
C 3 HOH 29 529 27 HOH HOH A . 
C 3 HOH 30 530 10 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ARG 271 ? CD  ? A ARG 271 CD  
2 1 Y 1 A ARG 271 ? NE  ? A ARG 271 NE  
3 1 Y 1 A ARG 271 ? CZ  ? A ARG 271 CZ  
4 1 Y 1 A ARG 271 ? NH1 ? A ARG 271 NH1 
5 1 Y 1 A ARG 271 ? NH2 ? A ARG 271 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .                    2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .                    3 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8VPL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     70.266 
_cell.length_a_esd                 ? 
_cell.length_b                     70.266 
_cell.length_b_esd                 ? 
_cell.length_c                     145.174 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8VPL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8VPL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.72 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.71 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Bis-Tris (pH 6.5), PEG 10000, and 0.2 M Potassium sodium tartrate tetrahydrate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     'IMAGE PLATE' 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'MAR scanner 300 mm plate' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-07-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9787 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 21-ID-F' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9787 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   21-ID-F 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8VPL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.84 
_reflns.d_resolution_low                               46.63 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     69327 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          19.23 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.047 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.9990000000000001 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.042 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
1.84 1.95  ? ? ? ? ? ? 11157 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.802               ? ? 1 1 0.777              ? ? ? ? 
0.7290000000000001  ? ? ? ? ? ? ? ? ? 
1.95 2.09  ? ? ? ? ? ? 10511 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.387               ? ? 2 1 0.937              ? ? ? ? 
0.35200000000000004 ? ? ? ? ? ? ? ? ? 
2.09 2.25  ? ? ? ? ? ? 9829  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.19399999999999998 ? ? 3 1 0.982              ? ? ? ? 
0.17600000000000002 ? ? ? ? ? ? ? ? ? 
2.25 2.47  ? ? ? ? ? ? 9021  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.111               ? ? 4 1 0.9940000000000001 ? ? ? ? 
0.10099999999999999 ? ? ? ? ? ? ? ? ? 
2.47 2.76  ? ? ? ? ? ? 8182  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.068               ? ? 5 1 0.997              ? ? ? ? 0.062 ? ? ? ? ? 
? ? ? ? 
2.76 3.18  ? ? ? ? ? ? 7217  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.049               ? ? 6 1 0.998              ? ? ? ? 0.045 ? ? ? ? ? 
? ? ? ? 
3.18 3.9   ? ? ? ? ? ? 6089  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.038               ? ? 7 1 0.9990000000000001 ? ? ? ? 0.035 ? ? ? ? ? 
? ? ? ? 
3.90 5.49  ? ? ? ? ? ? 4712  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.035               ? ? 8 1 0.9990000000000001 ? ? ? ? 0.032 ? ? ? ? ? 
? ? ? ? 
5.49 46.63 ? ? ? ? ? ? 2609  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.039               ? ? 9 1 0.997              ? ? ? ? 0.035 ? ? ? ? ? 
? ? ? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8VPL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.84 
_refine.ls_d_res_low                             46.63 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     36677 
_refine.ls_number_reflns_R_free                  1862 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.89 
_refine.ls_percent_reflns_R_free                 5.08 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2414 
_refine.ls_R_factor_R_free                       0.2601 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2404 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               NONE 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 32.48 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.30 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.84 
_refine_hist.d_res_low                        46.63 
_refine_hist.number_atoms_solvent             30 
_refine_hist.number_atoms_total               2718 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2687 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         1 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  ? 2775 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.182  ? 3792 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 17.101 ? 989  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.069  ? 423  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.011  ? 493  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.84 1.89  . . 143 2589 99.00  . . . . 0.3705 . . . . . . . . . . . 0.3969 
'X-RAY DIFFRACTION' 1.89 1.95  . . 147 2640 100.00 . . . . 0.3361 . . . . . . . . . . . 0.3959 
'X-RAY DIFFRACTION' 1.95 2.01  . . 141 2624 100.00 . . . . 0.3411 . . . . . . . . . . . 0.3555 
'X-RAY DIFFRACTION' 2.01 2.08  . . 136 2656 100.00 . . . . 0.3311 . . . . . . . . . . . 0.3217 
'X-RAY DIFFRACTION' 2.08 2.16  . . 139 2651 100.00 . . . . 0.3169 . . . . . . . . . . . 0.3481 
'X-RAY DIFFRACTION' 2.16 2.26  . . 170 2632 100.00 . . . . 0.3068 . . . . . . . . . . . 0.3420 
'X-RAY DIFFRACTION' 2.26 2.38  . . 156 2634 100.00 . . . . 0.2926 . . . . . . . . . . . 0.3115 
'X-RAY DIFFRACTION' 2.38 2.53  . . 159 2661 100.00 . . . . 0.2958 . . . . . . . . . . . 0.3103 
'X-RAY DIFFRACTION' 2.53 2.73  . . 141 2672 100.00 . . . . 0.2954 . . . . . . . . . . . 0.3429 
'X-RAY DIFFRACTION' 2.73 3.00  . . 117 2699 100.00 . . . . 0.2822 . . . . . . . . . . . 0.2881 
'X-RAY DIFFRACTION' 3.00 3.44  . . 125 2733 100.00 . . . . 0.2517 . . . . . . . . . . . 0.2673 
'X-RAY DIFFRACTION' 3.44 4.33  . . 151 2733 100.00 . . . . 0.2074 . . . . . . . . . . . 0.2093 
'X-RAY DIFFRACTION' 4.33 46.63 . . 137 2891 100.00 . . . . 0.1809 . . . . . . . . . . . 0.2045 
# 
_struct.entry_id                     8VPL 
_struct.title                        'Glutaminyl cyclase ApgG, diamond shape' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8VPL 
_struct_keywords.text            'Glutaminyl cyclase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A7U2MGR8_ASPFL 
_struct_ref.pdbx_db_accession          A0A7U2MGR8 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;DAHGNLSNADLEALLHPDGDTNIQTILAPLLRPRVPGTPGSELVRNYIIQFFNSALPLWTTELQVSSSKTPVSGSQRIPF
VNIIAYRSPPGLNETDVGWLTLVAHYDSLKDPEGFIGAIDSAAPCSIIMSAVRSIDAALTRKWDNMSSIPGDTHEQYGIQ
VIFTDGEESFGNTLTANDGLYGSRSLAAHWAVDKYPSTAKYETRLSSISLLVLLDLLGAKNPQIASYYPVTHFDYQRLAA
LESRLRELGQLKSSGIHGKSWFVDRTTDVRSLKRQPVEDDQVPFSGLGVKVLHVIDADPTTGEFPSVWHTPDDDENHLDF
DTIRDWSLLITAFAAEWLGLQGFMDN
;
_struct_ref.pdbx_align_begin           18 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8VPL 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 347 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A7U2MGR8 
_struct_ref_seq.db_align_beg                  18 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  363 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       347 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8VPL MET A 1   ? UNP A0A7U2MGR8 ? ? 'initiating methionine' 1   1 
1 8VPL HIS A 348 ? UNP A0A7U2MGR8 ? ? 'expression tag'        348 2 
1 8VPL HIS A 349 ? UNP A0A7U2MGR8 ? ? 'expression tag'        349 3 
1 8VPL HIS A 350 ? UNP A0A7U2MGR8 ? ? 'expression tag'        350 4 
1 8VPL HIS A 351 ? UNP A0A7U2MGR8 ? ? 'expression tag'        351 5 
1 8VPL HIS A 352 ? UNP A0A7U2MGR8 ? ? 'expression tag'        352 6 
1 8VPL HIS A 353 ? UNP A0A7U2MGR8 ? ? 'expression tag'        353 7 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2020  ? 
1 MORE         -66   ? 
1 'SSA (A^2)'  28270 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z      1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 4_645 y+1,x-1,-z -0.5000000000 0.8660254038 0.0000000000 105.3990000000 0.8660254038 0.5000000000 
0.0000000000 -60.8521410223 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 8   ? GLU A 13  ? SER A 8   GLU A 13  1 ? 6  
HELX_P HELX_P2  AA2 ASN A 23  ? ALA A 29  ? ASN A 23  ALA A 29  1 ? 7  
HELX_P HELX_P3  AA3 PRO A 30  ? LEU A 32  ? PRO A 30  LEU A 32  5 ? 3  
HELX_P HELX_P4  AA4 THR A 39  ? LEU A 57  ? THR A 39  LEU A 57  1 ? 19 
HELX_P HELX_P5  AA5 ASN A 94  ? VAL A 98  ? ASN A 94  VAL A 98  5 ? 5  
HELX_P HELX_P6  AA6 SER A 122 ? MET A 147 ? SER A 122 MET A 147 1 ? 26 
HELX_P HELX_P7  AA7 LEU A 181 ? VAL A 193 ? LEU A 181 VAL A 193 1 ? 13 
HELX_P HELX_P8  AA8 TYR A 229 ? VAL A 231 ? TYR A 229 VAL A 231 5 ? 3  
HELX_P HELX_P9  AA9 THR A 232 ? LEU A 249 ? THR A 232 LEU A 249 1 ? 18 
HELX_P HELX_P10 AB1 ASP A 269 ? LEU A 273 ? ASP A 269 LEU A 273 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 281 ? LEU A 288 ? ASP A 281 LEU A 288 1 ? 8  
HELX_P HELX_P12 AB3 ASP A 315 ? LEU A 319 ? ASP A 315 LEU A 319 5 ? 5  
HELX_P HELX_P13 AB4 ASP A 320 ? GLY A 340 ? ASP A 320 GLY A 340 1 ? 21 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A ASP 121 OD2 ? ? ? 1_555 B ZN . ZN ? ? A ASP 121 A ZN 401 1_555 ? ? ? ? ? ? ? 1.913 ? ? 
metalc2 metalc ? ? A GLU 169 OE2 ? ? ? 1_555 B ZN . ZN ? ? A GLU 169 A ZN 401 1_555 ? ? ? ? ? ? ? 1.711 ? ? 
metalc3 metalc ? ? A HIS 310 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 310 A ZN 401 1_555 ? ? ? ? ? ? ? 2.210 ? ? 
metalc4 metalc ? ? A HIS 353 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 353 A ZN 401 2_545 ? ? ? ? ? ? ? 2.073 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 OD2 ? A ASP 121 ? A ASP 121 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 OE2 ? A GLU 169 ? A GLU 169 ? 1_555 107.5 ? 
2 OD2 ? A ASP 121 ? A ASP 121 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 310 ? A HIS 310 ? 1_555 108.1 ? 
3 OE2 ? A GLU 169 ? A GLU 169 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 310 ? A HIS 310 ? 1_555 121.7 ? 
4 OD2 ? A ASP 121 ? A ASP 121 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 353 ? A HIS 353 ? 1_555 33.8  ? 
5 OE2 ? A GLU 169 ? A GLU 169 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 353 ? A HIS 353 ? 1_555 85.3  ? 
6 NE2 ? A HIS 310 ? A HIS 310 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 353 ? A HIS 353 ? 1_555 141.8 ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ASP 112 A . ? ASP 112 A PRO 113 A ? PRO 113 A 1 6.03  
2 ASP 121 A . ? ASP 121 A SER 122 A ? SER 122 A 1 -1.87 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   6 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 61  ? SER A 69  ? THR A 61  SER A 69  
AA1 2 ILE A 79  ? ARG A 88  ? ILE A 79  ARG A 88  
AA1 3 TYR A 158 ? THR A 165 ? TYR A 158 THR A 165 
AA1 4 GLY A 99  ? HIS A 106 ? GLY A 99  HIS A 106 
AA1 5 ILE A 209 ? ASP A 216 ? ILE A 209 ASP A 216 
AA1 6 VAL A 292 ? ILE A 296 ? VAL A 292 ILE A 296 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLU A 63  ? N GLU A 63  O ILE A 85  ? O ILE A 85  
AA1 2 3 N ALA A 86  ? N ALA A 86  O VAL A 162 ? O VAL A 162 
AA1 3 4 O GLN A 161 ? O GLN A 161 N LEU A 103 ? N LEU A 103 
AA1 4 5 N VAL A 104 ? N VAL A 104 O LEU A 215 ? O LEU A 215 
AA1 5 6 N LEU A 212 ? N LEU A 212 O LEU A 293 ? O LEU A 293 
# 
_pdbx_entry_details.entry_id                   8VPL 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 35  ? ? -143.93 55.26   
2 1 GLN A 157 ? ? -89.89  41.81   
3 1 LEU A 249 ? ? -58.36  -2.09   
4 1 ASP A 280 ? ? -175.96 -174.60 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ASP 2   ? A ASP 2   
3  1 Y 1 A SER 148 ? A SER 148 
4  1 Y 1 A SER 149 ? A SER 149 
5  1 Y 1 A ILE 150 ? A ILE 150 
6  1 Y 1 A PRO 151 ? A PRO 151 
7  1 Y 1 A GLY 152 ? A GLY 152 
8  1 Y 1 A ASP 153 ? A ASP 153 
9  1 Y 1 A THR 154 ? A THR 154 
10 1 Y 1 A HIS 155 ? A HIS 155 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
PHE N    N  N N 250 
PHE CA   C  N S 251 
PHE C    C  N N 252 
PHE O    O  N N 253 
PHE CB   C  N N 254 
PHE CG   C  Y N 255 
PHE CD1  C  Y N 256 
PHE CD2  C  Y N 257 
PHE CE1  C  Y N 258 
PHE CE2  C  Y N 259 
PHE CZ   C  Y N 260 
PHE OXT  O  N N 261 
PHE H    H  N N 262 
PHE H2   H  N N 263 
PHE HA   H  N N 264 
PHE HB2  H  N N 265 
PHE HB3  H  N N 266 
PHE HD1  H  N N 267 
PHE HD2  H  N N 268 
PHE HE1  H  N N 269 
PHE HE2  H  N N 270 
PHE HZ   H  N N 271 
PHE HXT  H  N N 272 
PRO N    N  N N 273 
PRO CA   C  N S 274 
PRO C    C  N N 275 
PRO O    O  N N 276 
PRO CB   C  N N 277 
PRO CG   C  N N 278 
PRO CD   C  N N 279 
PRO OXT  O  N N 280 
PRO H    H  N N 281 
PRO HA   H  N N 282 
PRO HB2  H  N N 283 
PRO HB3  H  N N 284 
PRO HG2  H  N N 285 
PRO HG3  H  N N 286 
PRO HD2  H  N N 287 
PRO HD3  H  N N 288 
PRO HXT  H  N N 289 
SER N    N  N N 290 
SER CA   C  N S 291 
SER C    C  N N 292 
SER O    O  N N 293 
SER CB   C  N N 294 
SER OG   O  N N 295 
SER OXT  O  N N 296 
SER H    H  N N 297 
SER H2   H  N N 298 
SER HA   H  N N 299 
SER HB2  H  N N 300 
SER HB3  H  N N 301 
SER HG   H  N N 302 
SER HXT  H  N N 303 
THR N    N  N N 304 
THR CA   C  N S 305 
THR C    C  N N 306 
THR O    O  N N 307 
THR CB   C  N R 308 
THR OG1  O  N N 309 
THR CG2  C  N N 310 
THR OXT  O  N N 311 
THR H    H  N N 312 
THR H2   H  N N 313 
THR HA   H  N N 314 
THR HB   H  N N 315 
THR HG1  H  N N 316 
THR HG21 H  N N 317 
THR HG22 H  N N 318 
THR HG23 H  N N 319 
THR HXT  H  N N 320 
TRP N    N  N N 321 
TRP CA   C  N S 322 
TRP C    C  N N 323 
TRP O    O  N N 324 
TRP CB   C  N N 325 
TRP CG   C  Y N 326 
TRP CD1  C  Y N 327 
TRP CD2  C  Y N 328 
TRP NE1  N  Y N 329 
TRP CE2  C  Y N 330 
TRP CE3  C  Y N 331 
TRP CZ2  C  Y N 332 
TRP CZ3  C  Y N 333 
TRP CH2  C  Y N 334 
TRP OXT  O  N N 335 
TRP H    H  N N 336 
TRP H2   H  N N 337 
TRP HA   H  N N 338 
TRP HB2  H  N N 339 
TRP HB3  H  N N 340 
TRP HD1  H  N N 341 
TRP HE1  H  N N 342 
TRP HE3  H  N N 343 
TRP HZ2  H  N N 344 
TRP HZ3  H  N N 345 
TRP HH2  H  N N 346 
TRP HXT  H  N N 347 
TYR N    N  N N 348 
TYR CA   C  N S 349 
TYR C    C  N N 350 
TYR O    O  N N 351 
TYR CB   C  N N 352 
TYR CG   C  Y N 353 
TYR CD1  C  Y N 354 
TYR CD2  C  Y N 355 
TYR CE1  C  Y N 356 
TYR CE2  C  Y N 357 
TYR CZ   C  Y N 358 
TYR OH   O  N N 359 
TYR OXT  O  N N 360 
TYR H    H  N N 361 
TYR H2   H  N N 362 
TYR HA   H  N N 363 
TYR HB2  H  N N 364 
TYR HB3  H  N N 365 
TYR HD1  H  N N 366 
TYR HD2  H  N N 367 
TYR HE1  H  N N 368 
TYR HE2  H  N N 369 
TYR HH   H  N N 370 
TYR HXT  H  N N 371 
VAL N    N  N N 372 
VAL CA   C  N S 373 
VAL C    C  N N 374 
VAL O    O  N N 375 
VAL CB   C  N N 376 
VAL CG1  C  N N 377 
VAL CG2  C  N N 378 
VAL OXT  O  N N 379 
VAL H    H  N N 380 
VAL H2   H  N N 381 
VAL HA   H  N N 382 
VAL HB   H  N N 383 
VAL HG11 H  N N 384 
VAL HG12 H  N N 385 
VAL HG13 H  N N 386 
VAL HG21 H  N N 387 
VAL HG22 H  N N 388 
VAL HG23 H  N N 389 
VAL HXT  H  N N 390 
ZN  ZN   ZN N N 391 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R23490 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8VPL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014232 
_atom_sites.fract_transf_matrix[1][2]   0.008217 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016433 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006888 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
O  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ALA A 1 3   ? 59.717 -24.998 22.740  1.00 56.39 ? 3   ALA A N   1 
ATOM   2    C  CA  . ALA A 1 3   ? 59.684 -25.583 24.102  1.00 64.01 ? 3   ALA A CA  1 
ATOM   3    C  C   . ALA A 1 3   ? 58.242 -25.747 24.594  1.00 60.48 ? 3   ALA A C   1 
ATOM   4    O  O   . ALA A 1 3   ? 57.335 -25.347 23.851  1.00 61.86 ? 3   ALA A O   1 
ATOM   5    C  CB  . ALA A 1 3   ? 60.475 -24.738 25.058  1.00 55.62 ? 3   ALA A CB  1 
ATOM   6    N  N   . HIS A 1 4   ? 58.060 -26.296 25.804  1.00 64.20 ? 4   HIS A N   1 
ATOM   7    C  CA  . HIS A 1 4   ? 56.699 -26.562 26.348  1.00 56.32 ? 4   HIS A CA  1 
ATOM   8    C  C   . HIS A 1 4   ? 56.741 -27.007 27.815  1.00 59.60 ? 4   HIS A C   1 
ATOM   9    O  O   . HIS A 1 4   ? 57.827 -27.347 28.320  1.00 63.83 ? 4   HIS A O   1 
ATOM   10   C  CB  . HIS A 1 4   ? 55.967 -27.578 25.465  1.00 54.69 ? 4   HIS A CB  1 
ATOM   11   C  CG  . HIS A 1 4   ? 56.267 -29.020 25.670  1.00 62.87 ? 4   HIS A CG  1 
ATOM   12   N  ND1 . HIS A 1 4   ? 57.348 -29.650 25.095  1.00 64.94 ? 4   HIS A ND1 1 
ATOM   13   C  CD2 . HIS A 1 4   ? 55.592 -29.966 26.328  1.00 60.73 ? 4   HIS A CD2 1 
ATOM   14   C  CE1 . HIS A 1 4   ? 57.332 -30.930 25.431  1.00 65.59 ? 4   HIS A CE1 1 
ATOM   15   N  NE2 . HIS A 1 4   ? 56.274 -31.143 26.180  1.00 64.14 ? 4   HIS A NE2 1 
ATOM   16   N  N   . GLY A 1 5   ? 55.582 -27.001 28.478  1.00 52.41 ? 5   GLY A N   1 
ATOM   17   C  CA  . GLY A 1 5   ? 55.476 -27.456 29.874  1.00 51.31 ? 5   GLY A CA  1 
ATOM   18   C  C   . GLY A 1 5   ? 54.426 -28.544 30.015  1.00 54.01 ? 5   GLY A C   1 
ATOM   19   O  O   . GLY A 1 5   ? 54.224 -29.280 29.040  1.00 54.28 ? 5   GLY A O   1 
ATOM   20   N  N   . ASN A 1 6   ? 53.801 -28.663 31.189  1.00 52.17 ? 6   ASN A N   1 
ATOM   21   C  CA  . ASN A 1 6   ? 52.711 -29.651 31.390  1.00 52.67 ? 6   ASN A CA  1 
ATOM   22   C  C   . ASN A 1 6   ? 51.626 -29.041 32.274  1.00 48.81 ? 6   ASN A C   1 
ATOM   23   O  O   . ASN A 1 6   ? 51.959 -28.573 33.357  1.00 54.10 ? 6   ASN A O   1 
ATOM   24   C  CB  . ASN A 1 6   ? 53.199 -30.970 31.976  1.00 50.45 ? 6   ASN A CB  1 
ATOM   25   C  CG  . ASN A 1 6   ? 52.076 -31.974 32.105  1.00 54.10 ? 6   ASN A CG  1 
ATOM   26   O  OD1 . ASN A 1 6   ? 51.364 -32.239 31.140  1.00 53.57 ? 6   ASN A OD1 1 
ATOM   27   N  ND2 . ASN A 1 6   ? 51.897 -32.520 33.296  1.00 55.16 ? 6   ASN A ND2 1 
ATOM   28   N  N   . LEU A 1 7   ? 50.380 -29.095 31.829  1.00 47.40 ? 7   LEU A N   1 
ATOM   29   C  CA  . LEU A 1 7   ? 49.275 -28.436 32.556  1.00 47.41 ? 7   LEU A CA  1 
ATOM   30   C  C   . LEU A 1 7   ? 48.611 -29.409 33.526  1.00 52.05 ? 7   LEU A C   1 
ATOM   31   O  O   . LEU A 1 7   ? 48.230 -30.508 33.113  1.00 48.49 ? 7   LEU A O   1 
ATOM   32   C  CB  . LEU A 1 7   ? 48.240 -27.911 31.558  1.00 45.84 ? 7   LEU A CB  1 
ATOM   33   C  CG  . LEU A 1 7   ? 48.656 -26.724 30.693  1.00 45.26 ? 7   LEU A CG  1 
ATOM   34   C  CD1 . LEU A 1 7   ? 47.432 -26.047 30.102  1.00 40.19 ? 7   LEU A CD1 1 
ATOM   35   C  CD2 . LEU A 1 7   ? 49.478 -25.727 31.488  1.00 44.02 ? 7   LEU A CD2 1 
ATOM   36   N  N   . SER A 1 8   ? 48.509 -29.004 34.779  1.00 51.25 ? 8   SER A N   1 
ATOM   37   C  CA  . SER A 1 8   ? 47.763 -29.789 35.780  1.00 51.44 ? 8   SER A CA  1 
ATOM   38   C  C   . SER A 1 8   ? 46.270 -29.661 35.503  1.00 52.81 ? 8   SER A C   1 
ATOM   39   O  O   . SER A 1 8   ? 45.873 -28.727 34.805  1.00 50.45 ? 8   SER A O   1 
ATOM   40   C  CB  . SER A 1 8   ? 48.062 -29.259 37.145  1.00 47.77 ? 8   SER A CB  1 
ATOM   41   O  OG  . SER A 1 8   ? 47.373 -28.041 37.373  1.00 53.67 ? 8   SER A OG  1 
ATOM   42   N  N   . ASN A 1 9   ? 45.461 -30.568 36.038  1.00 53.20 ? 9   ASN A N   1 
ATOM   43   C  CA  . ASN A 1 9   ? 43.988 -30.493 35.865  1.00 54.76 ? 9   ASN A CA  1 
ATOM   44   C  C   . ASN A 1 9   ? 43.460 -29.178 36.441  1.00 54.09 ? 9   ASN A C   1 
ATOM   45   O  O   . ASN A 1 9   ? 42.437 -28.690 35.948  1.00 53.42 ? 9   ASN A O   1 
ATOM   46   C  CB  . ASN A 1 9   ? 43.287 -31.688 36.505  1.00 54.63 ? 9   ASN A CB  1 
ATOM   47   C  CG  . ASN A 1 9   ? 43.418 -32.955 35.690  1.00 58.69 ? 9   ASN A CG  1 
ATOM   48   O  OD1 . ASN A 1 9   ? 44.037 -32.956 34.631  1.00 58.28 ? 9   ASN A OD1 1 
ATOM   49   N  ND2 . ASN A 1 9   ? 42.840 -34.039 36.178  1.00 56.17 ? 9   ASN A ND2 1 
ATOM   50   N  N   . ALA A 1 10  ? 44.148 -28.630 37.437  1.00 51.57 ? 10  ALA A N   1 
ATOM   51   C  CA  . ALA A 1 10  ? 43.739 -27.347 38.044  1.00 55.86 ? 10  ALA A CA  1 
ATOM   52   C  C   . ALA A 1 10  ? 43.946 -26.229 37.027  1.00 53.67 ? 10  ALA A C   1 
ATOM   53   O  O   . ALA A 1 10  ? 43.060 -25.371 36.898  1.00 51.31 ? 10  ALA A O   1 
ATOM   54   C  CB  . ALA A 1 10  ? 44.563 -27.105 39.279  1.00 52.48 ? 10  ALA A CB  1 
ATOM   55   N  N   . ASP A 1 11  ? 45.090 -26.253 36.350  1.00 53.17 ? 11  ASP A N   1 
ATOM   56   C  CA  . ASP A 1 11  ? 45.397 -25.250 35.306  1.00 51.31 ? 11  ASP A CA  1 
ATOM   57   C  C   . ASP A 1 11  ? 44.296 -25.282 34.257  1.00 50.76 ? 11  ASP A C   1 
ATOM   58   O  O   . ASP A 1 11  ? 43.954 -24.222 33.742  1.00 53.53 ? 11  ASP A O   1 
ATOM   59   C  CB  . ASP A 1 11  ? 46.742 -25.557 34.653  1.00 51.51 ? 11  ASP A CB  1 
ATOM   60   C  CG  . ASP A 1 11  ? 47.951 -25.456 35.561  1.00 53.76 ? 11  ASP A CG  1 
ATOM   61   O  OD1 . ASP A 1 11  ? 48.040 -24.472 36.311  1.00 54.48 ? 11  ASP A OD1 1 
ATOM   62   O  OD2 . ASP A 1 11  ? 48.804 -26.355 35.484  1.00 52.80 ? 11  ASP A OD2 1 
ATOM   63   N  N   . LEU A 1 12  ? 43.755 -26.462 33.979  1.00 48.14 ? 12  LEU A N   1 
ATOM   64   C  CA  . LEU A 1 12  ? 42.754 -26.615 32.901  1.00 50.30 ? 12  LEU A CA  1 
ATOM   65   C  C   . LEU A 1 12  ? 41.402 -26.071 33.354  1.00 53.89 ? 12  LEU A C   1 
ATOM   66   O  O   . LEU A 1 12  ? 40.573 -25.767 32.491  1.00 51.16 ? 12  LEU A O   1 
ATOM   67   C  CB  . LEU A 1 12  ? 42.658 -28.098 32.546  1.00 47.73 ? 12  LEU A CB  1 
ATOM   68   C  CG  . LEU A 1 12  ? 43.909 -28.694 31.906  1.00 49.66 ? 12  LEU A CG  1 
ATOM   69   C  CD1 . LEU A 1 12  ? 43.642 -30.108 31.413  1.00 47.93 ? 12  LEU A CD1 1 
ATOM   70   C  CD2 . LEU A 1 12  ? 44.392 -27.817 30.765  1.00 49.60 ? 12  LEU A CD2 1 
ATOM   71   N  N   . GLU A 1 13  ? 41.195 -25.974 34.659  1.00 55.52 ? 13  GLU A N   1 
ATOM   72   C  CA  . GLU A 1 13  ? 39.879 -25.513 35.169  1.00 58.01 ? 13  GLU A CA  1 
ATOM   73   C  C   . GLU A 1 13  ? 39.879 -23.986 35.299  1.00 51.90 ? 13  GLU A C   1 
ATOM   74   O  O   . GLU A 1 13  ? 38.821 -23.429 35.598  1.00 53.24 ? 13  GLU A O   1 
ATOM   75   C  CB  . GLU A 1 13  ? 39.559 -26.225 36.480  1.00 59.94 ? 13  GLU A CB  1 
ATOM   76   C  CG  . GLU A 1 13  ? 39.463 -27.731 36.339  1.00 61.37 ? 13  GLU A CG  1 
ATOM   77   C  CD  . GLU A 1 13  ? 39.528 -28.480 37.657  1.00 69.06 ? 13  GLU A CD  1 
ATOM   78   O  OE1 . GLU A 1 13  ? 39.001 -27.957 38.654  1.00 71.30 ? 13  GLU A OE1 1 
ATOM   79   O  OE2 . GLU A 1 13  ? 40.110 -29.580 37.683  1.00 72.40 ? 13  GLU A OE2 1 
ATOM   80   N  N   . ALA A 1 14  ? 41.015 -23.344 35.053  1.00 55.00 ? 14  ALA A N   1 
ATOM   81   C  CA  . ALA A 1 14  ? 41.130 -21.878 35.189  1.00 53.59 ? 14  ALA A CA  1 
ATOM   82   C  C   . ALA A 1 14  ? 41.446 -21.225 33.848  1.00 56.94 ? 14  ALA A C   1 
ATOM   83   O  O   . ALA A 1 14  ? 42.139 -20.208 33.862  1.00 60.63 ? 14  ALA A O   1 
ATOM   84   C  CB  . ALA A 1 14  ? 42.251 -21.619 36.142  1.00 55.16 ? 14  ALA A CB  1 
ATOM   85   N  N   . LEU A 1 15  ? 40.945 -21.762 32.738  1.00 59.68 ? 15  LEU A N   1 
ATOM   86   C  CA  . LEU A 1 15  ? 41.371 -21.247 31.403  1.00 64.94 ? 15  LEU A CA  1 
ATOM   87   C  C   . LEU A 1 15  ? 40.619 -19.967 30.983  1.00 70.67 ? 15  LEU A C   1 
ATOM   88   O  O   . LEU A 1 15  ? 41.262 -19.079 30.393  1.00 62.97 ? 15  LEU A O   1 
ATOM   89   C  CB  . LEU A 1 15  ? 41.173 -22.370 30.383  1.00 58.84 ? 15  LEU A CB  1 
ATOM   90   C  CG  . LEU A 1 15  ? 42.442 -23.086 29.929  1.00 55.84 ? 15  LEU A CG  1 
ATOM   91   C  CD1 . LEU A 1 15  ? 43.542 -22.942 30.965  1.00 56.60 ? 15  LEU A CD1 1 
ATOM   92   C  CD2 . LEU A 1 15  ? 42.161 -24.551 29.642  1.00 51.70 ? 15  LEU A CD2 1 
ATOM   93   N  N   . LEU A 1 16  ? 39.310 -19.897 31.230  1.00 70.34 ? 16  LEU A N   1 
ATOM   94   C  CA  . LEU A 1 16  ? 38.499 -18.726 30.793  1.00 74.16 ? 16  LEU A CA  1 
ATOM   95   C  C   . LEU A 1 16  ? 39.104 -17.424 31.324  1.00 75.72 ? 16  LEU A C   1 
ATOM   96   O  O   . LEU A 1 16  ? 39.678 -17.439 32.421  1.00 77.98 ? 16  LEU A O   1 
ATOM   97   C  CB  . LEU A 1 16  ? 37.068 -18.898 31.305  1.00 73.05 ? 16  LEU A CB  1 
ATOM   98   C  CG  . LEU A 1 16  ? 36.921 -18.816 32.822  1.00 75.54 ? 16  LEU A CG  1 
ATOM   99   C  CD1 . LEU A 1 16  ? 36.001 -17.672 33.216  1.00 75.84 ? 16  LEU A CD1 1 
ATOM   100  C  CD2 . LEU A 1 16  ? 36.428 -20.136 33.398  1.00 66.50 ? 16  LEU A CD2 1 
ATOM   101  N  N   . HIS A 1 17  ? 38.976 -16.338 30.559  1.00 74.72 ? 17  HIS A N   1 
ATOM   102  C  CA  . HIS A 1 17  ? 39.475 -15.010 30.996  1.00 73.12 ? 17  HIS A CA  1 
ATOM   103  C  C   . HIS A 1 17  ? 38.480 -14.433 32.011  1.00 76.43 ? 17  HIS A C   1 
ATOM   104  O  O   . HIS A 1 17  ? 37.284 -14.760 31.931  1.00 74.07 ? 17  HIS A O   1 
ATOM   105  C  CB  . HIS A 1 17  ? 39.667 -14.101 29.775  1.00 69.12 ? 17  HIS A CB  1 
ATOM   106  C  CG  . HIS A 1 17  ? 40.171 -12.735 30.090  1.00 70.99 ? 17  HIS A CG  1 
ATOM   107  N  ND1 . HIS A 1 17  ? 39.329 -11.701 30.442  1.00 73.98 ? 17  HIS A ND1 1 
ATOM   108  C  CD2 . HIS A 1 17  ? 41.422 -12.230 30.110  1.00 61.53 ? 17  HIS A CD2 1 
ATOM   109  C  CE1 . HIS A 1 17  ? 40.040 -10.618 30.673  1.00 69.82 ? 17  HIS A CE1 1 
ATOM   110  N  NE2 . HIS A 1 17  ? 41.326 -10.916 30.473  1.00 70.27 ? 17  HIS A NE2 1 
ATOM   111  N  N   . PRO A 1 18  ? 38.933 -13.597 32.961  1.00 77.01 ? 18  PRO A N   1 
ATOM   112  C  CA  . PRO A 1 18  ? 38.045 -13.013 33.965  1.00 78.24 ? 18  PRO A CA  1 
ATOM   113  C  C   . PRO A 1 18  ? 36.905 -12.131 33.424  1.00 77.89 ? 18  PRO A C   1 
ATOM   114  O  O   . PRO A 1 18  ? 35.980 -11.899 34.152  1.00 78.85 ? 18  PRO A O   1 
ATOM   115  C  CB  . PRO A 1 18  ? 39.021 -12.167 34.801  1.00 75.38 ? 18  PRO A CB  1 
ATOM   116  C  CG  . PRO A 1 18  ? 40.194 -11.920 33.895  1.00 75.39 ? 18  PRO A CG  1 
ATOM   117  C  CD  . PRO A 1 18  ? 40.333 -13.232 33.163  1.00 77.62 ? 18  PRO A CD  1 
ATOM   118  N  N   . ASP A 1 19  ? 36.994 -11.634 32.193  1.00 78.17 ? 19  ASP A N   1 
ATOM   119  C  CA  . ASP A 1 19  ? 35.945 -10.693 31.704  1.00 79.53 ? 19  ASP A CA  1 
ATOM   120  C  C   . ASP A 1 19  ? 34.812 -11.474 31.045  1.00 79.52 ? 19  ASP A C   1 
ATOM   121  O  O   . ASP A 1 19  ? 34.960 -11.863 29.880  1.00 83.14 ? 19  ASP A O   1 
ATOM   122  C  CB  . ASP A 1 19  ? 36.508 -9.633  30.759  1.00 77.11 ? 19  ASP A CB  1 
ATOM   123  C  CG  . ASP A 1 19  ? 37.321 -8.584  31.497  1.00 80.94 ? 19  ASP A CG  1 
ATOM   124  O  OD1 . ASP A 1 19  ? 37.260 -8.577  32.741  1.00 79.13 ? 19  ASP A OD1 1 
ATOM   125  O  OD2 . ASP A 1 19  ? 38.008 -7.789  30.827  1.00 77.46 ? 19  ASP A OD2 1 
ATOM   126  N  N   . GLY A 1 20  ? 33.719 -11.678 31.773  1.00 78.31 ? 20  GLY A N   1 
ATOM   127  C  CA  . GLY A 1 20  ? 32.605 -12.470 31.226  1.00 80.26 ? 20  GLY A CA  1 
ATOM   128  C  C   . GLY A 1 20  ? 31.841 -11.677 30.194  1.00 81.74 ? 20  GLY A C   1 
ATOM   129  O  O   . GLY A 1 20  ? 31.192 -12.293 29.329  1.00 78.01 ? 20  GLY A O   1 
ATOM   130  N  N   . ASP A 1 21  ? 31.944 -10.354 30.267  1.00 78.24 ? 21  ASP A N   1 
ATOM   131  C  CA  . ASP A 1 21  ? 31.152 -9.500  29.351  1.00 79.47 ? 21  ASP A CA  1 
ATOM   132  C  C   . ASP A 1 21  ? 31.774 -9.513  27.949  1.00 77.60 ? 21  ASP A C   1 
ATOM   133  O  O   . ASP A 1 21  ? 31.015 -9.347  26.981  1.00 76.12 ? 21  ASP A O   1 
ATOM   134  C  CB  . ASP A 1 21  ? 30.971 -8.118  29.977  1.00 77.86 ? 21  ASP A CB  1 
ATOM   135  C  CG  . ASP A 1 21  ? 30.057 -8.162  31.189  1.00 77.05 ? 21  ASP A CG  1 
ATOM   136  O  OD1 . ASP A 1 21  ? 30.395 -8.878  32.149  1.00 76.53 ? 21  ASP A OD1 1 
ATOM   137  O  OD2 . ASP A 1 21  ? 29.006 -7.498  31.155  1.00 75.40 ? 21  ASP A OD2 1 
ATOM   138  N  N   . THR A 1 22  ? 33.086 -9.724  27.846  1.00 77.24 ? 22  THR A N   1 
ATOM   139  C  CA  . THR A 1 22  ? 33.735 -9.831  26.516  1.00 71.98 ? 22  THR A CA  1 
ATOM   140  C  C   . THR A 1 22  ? 33.849 -11.311 26.137  1.00 73.49 ? 22  THR A C   1 
ATOM   141  O  O   . THR A 1 22  ? 34.894 -11.902 26.435  1.00 75.06 ? 22  THR A O   1 
ATOM   142  C  CB  . THR A 1 22  ? 35.078 -9.097  26.508  1.00 72.29 ? 22  THR A CB  1 
ATOM   143  O  OG1 . THR A 1 22  ? 34.923 -7.871  27.221  1.00 71.85 ? 22  THR A OG1 1 
ATOM   144  C  CG2 . THR A 1 22  ? 35.583 -8.820  25.109  1.00 65.10 ? 22  THR A CG2 1 
ATOM   145  N  N   . ASN A 1 23  ? 32.817 -11.872 25.502  1.00 69.47 ? 23  ASN A N   1 
ATOM   146  C  CA  . ASN A 1 23  ? 32.794 -13.315 25.141  1.00 65.87 ? 23  ASN A CA  1 
ATOM   147  C  C   . ASN A 1 23  ? 33.136 -13.503 23.655  1.00 62.20 ? 23  ASN A C   1 
ATOM   148  O  O   . ASN A 1 23  ? 33.375 -12.504 22.972  1.00 61.00 ? 23  ASN A O   1 
ATOM   149  C  CB  . ASN A 1 23  ? 31.440 -13.938 25.483  1.00 60.80 ? 23  ASN A CB  1 
ATOM   150  C  CG  . ASN A 1 23  ? 30.288 -13.283 24.751  1.00 64.66 ? 23  ASN A CG  1 
ATOM   151  O  OD1 . ASN A 1 23  ? 30.328 -13.117 23.536  1.00 63.35 ? 23  ASN A OD1 1 
ATOM   152  N  ND2 . ASN A 1 23  ? 29.251 -12.916 25.483  1.00 65.85 ? 23  ASN A ND2 1 
ATOM   153  N  N   . ILE A 1 24  ? 33.127 -14.744 23.169  1.00 59.51 ? 24  ILE A N   1 
ATOM   154  C  CA  . ILE A 1 24  ? 33.546 -15.008 21.762  1.00 55.63 ? 24  ILE A CA  1 
ATOM   155  C  C   . ILE A 1 24  ? 32.514 -14.420 20.793  1.00 55.72 ? 24  ILE A C   1 
ATOM   156  O  O   . ILE A 1 24  ? 32.932 -13.867 19.775  1.00 52.45 ? 24  ILE A O   1 
ATOM   157  C  CB  . ILE A 1 24  ? 33.789 -16.511 21.530  1.00 52.42 ? 24  ILE A CB  1 
ATOM   158  C  CG1 . ILE A 1 24  ? 34.535 -16.760 20.217  1.00 53.29 ? 24  ILE A CG1 1 
ATOM   159  C  CG2 . ILE A 1 24  ? 32.489 -17.295 21.600  1.00 60.01 ? 24  ILE A CG2 1 
ATOM   160  C  CD1 . ILE A 1 24  ? 36.022 -16.944 20.387  1.00 48.40 ? 24  ILE A CD1 1 
ATOM   161  N  N   . GLN A 1 25  ? 31.225 -14.521 21.107  1.00 52.19 ? 25  GLN A N   1 
ATOM   162  C  CA  . GLN A 1 25  ? 30.186 -13.899 20.245  1.00 53.45 ? 25  GLN A CA  1 
ATOM   163  C  C   . GLN A 1 25  ? 30.479 -12.404 20.112  1.00 47.96 ? 25  GLN A C   1 
ATOM   164  O  O   . GLN A 1 25  ? 30.393 -11.888 18.999  1.00 47.70 ? 25  GLN A O   1 
ATOM   165  C  CB  . GLN A 1 25  ? 28.804 -14.155 20.839  1.00 58.61 ? 25  GLN A CB  1 
ATOM   166  C  CG  . GLN A 1 25  ? 28.580 -15.605 21.244  1.00 63.01 ? 25  GLN A CG  1 
ATOM   167  C  CD  . GLN A 1 25  ? 28.706 -15.830 22.731  1.00 65.82 ? 25  GLN A CD  1 
ATOM   168  O  OE1 . GLN A 1 25  ? 27.716 -15.926 23.449  1.00 71.52 ? 25  GLN A OE1 1 
ATOM   169  N  NE2 . GLN A 1 25  ? 29.935 -15.927 23.208  1.00 65.85 ? 25  GLN A NE2 1 
ATOM   170  N  N   . THR A 1 26  ? 30.838 -11.764 21.216  1.00 49.16 ? 26  THR A N   1 
ATOM   171  C  CA  . THR A 1 26  ? 31.167 -10.323 21.204  1.00 50.37 ? 26  THR A CA  1 
ATOM   172  C  C   . THR A 1 26  ? 32.363 -10.077 20.283  1.00 52.43 ? 26  THR A C   1 
ATOM   173  O  O   . THR A 1 26  ? 32.285 -9.164  19.463  1.00 45.22 ? 26  THR A O   1 
ATOM   174  C  CB  . THR A 1 26  ? 31.462 -9.844  22.628  1.00 52.67 ? 26  THR A CB  1 
ATOM   175  O  OG1 . THR A 1 26  ? 30.300 -10.095 23.416  1.00 62.31 ? 26  THR A OG1 1 
ATOM   176  C  CG2 . THR A 1 26  ? 31.833 -8.380  22.696  1.00 57.96 ? 26  THR A CG2 1 
ATOM   177  N  N   . ILE A 1 27  ? 33.427 -10.865 20.430  1.00 46.18 ? 27  ILE A N   1 
ATOM   178  C  CA  . ILE A 1 27  ? 34.668 -10.660 19.627  1.00 45.81 ? 27  ILE A CA  1 
ATOM   179  C  C   . ILE A 1 27  ? 34.388 -11.032 18.176  1.00 39.90 ? 27  ILE A C   1 
ATOM   180  O  O   . ILE A 1 27  ? 34.902 -10.355 17.291  1.00 45.78 ? 27  ILE A O   1 
ATOM   181  C  CB  . ILE A 1 27  ? 35.827 -11.483 20.221  1.00 48.10 ? 27  ILE A CB  1 
ATOM   182  C  CG1 . ILE A 1 27  ? 36.303 -10.907 21.555  1.00 48.49 ? 27  ILE A CG1 1 
ATOM   183  C  CG2 . ILE A 1 27  ? 36.968 -11.617 19.226  1.00 43.31 ? 27  ILE A CG2 1 
ATOM   184  C  CD1 . ILE A 1 27  ? 36.886 -11.933 22.493  1.00 50.35 ? 27  ILE A CD1 1 
ATOM   185  N  N   . LEU A 1 28  ? 33.575 -12.057 17.957  1.00 41.19 ? 28  LEU A N   1 
ATOM   186  C  CA  . LEU A 1 28  ? 33.319 -12.519 16.600  1.00 43.04 ? 28  LEU A CA  1 
ATOM   187  C  C   . LEU A 1 28  ? 32.454 -11.537 15.817  1.00 46.08 ? 28  LEU A C   1 
ATOM   188  O  O   . LEU A 1 28  ? 32.706 -11.291 14.632  1.00 39.99 ? 28  LEU A O   1 
ATOM   189  C  CB  . LEU A 1 28  ? 32.659 -13.898 16.651  1.00 40.53 ? 28  LEU A CB  1 
ATOM   190  C  CG  . LEU A 1 28  ? 32.115 -14.493 15.364  1.00 42.97 ? 28  LEU A CG  1 
ATOM   191  C  CD1 . LEU A 1 28  ? 33.265 -14.710 14.387  1.00 41.30 ? 28  LEU A CD1 1 
ATOM   192  C  CD2 . LEU A 1 28  ? 31.378 -15.783 15.657  1.00 46.39 ? 28  LEU A CD2 1 
ATOM   193  N  N   . ALA A 1 29  ? 31.425 -10.965 16.454  1.00 47.49 ? 29  ALA A N   1 
ATOM   194  C  CA  . ALA A 1 29  ? 30.402 -10.245 15.690  1.00 42.25 ? 29  ALA A CA  1 
ATOM   195  C  C   . ALA A 1 29  ? 30.951 -9.203  14.717  1.00 39.61 ? 29  ALA A C   1 
ATOM   196  O  O   . ALA A 1 29  ? 30.559 -9.240  13.537  1.00 43.90 ? 29  ALA A O   1 
ATOM   197  C  CB  . ALA A 1 29  ? 29.389 -9.619  16.664  1.00 47.54 ? 29  ALA A CB  1 
ATOM   198  N  N   . PRO A 1 30  ? 31.853 -8.287  15.101  1.00 37.39 ? 30  PRO A N   1 
ATOM   199  C  CA  . PRO A 1 30  ? 32.345 -7.305  14.121  1.00 36.18 ? 30  PRO A CA  1 
ATOM   200  C  C   . PRO A 1 30  ? 33.130 -7.906  12.955  1.00 43.70 ? 30  PRO A C   1 
ATOM   201  O  O   . PRO A 1 30  ? 33.396 -7.175  11.993  1.00 37.59 ? 30  PRO A O   1 
ATOM   202  C  CB  . PRO A 1 30  ? 33.236 -6.372  14.953  1.00 38.12 ? 30  PRO A CB  1 
ATOM   203  C  CG  . PRO A 1 30  ? 32.906 -6.640  16.357  1.00 44.18 ? 30  PRO A CG  1 
ATOM   204  C  CD  . PRO A 1 30  ? 32.473 -8.069  16.415  1.00 40.98 ? 30  PRO A CD  1 
ATOM   205  N  N   . LEU A 1 31  ? 33.500 -9.201  12.999  1.00 44.92 ? 31  LEU A N   1 
ATOM   206  C  CA  . LEU A 1 31  ? 34.182 -9.838  11.872  1.00 40.12 ? 31  LEU A CA  1 
ATOM   207  C  C   . LEU A 1 31  ? 33.222 -10.355 10.823  1.00 42.13 ? 31  LEU A C   1 
ATOM   208  O  O   . LEU A 1 31  ? 33.633 -10.564 9.677   1.00 41.68 ? 31  LEU A O   1 
ATOM   209  C  CB  . LEU A 1 31  ? 35.043 -11.027 12.349  1.00 36.03 ? 31  LEU A CB  1 
ATOM   210  C  CG  . LEU A 1 31  ? 36.011 -10.719 13.478  1.00 35.91 ? 31  LEU A CG  1 
ATOM   211  C  CD1 . LEU A 1 31  ? 36.675 -12.038 13.942  1.00 39.63 ? 31  LEU A CD1 1 
ATOM   212  C  CD2 . LEU A 1 31  ? 37.047 -9.689  13.063  1.00 37.55 ? 31  LEU A CD2 1 
ATOM   213  N  N   . LEU A 1 32  ? 31.954 -10.562 11.182  1.00 41.06 ? 32  LEU A N   1 
ATOM   214  C  CA  . LEU A 1 32  ? 31.020 -11.272 10.315  1.00 38.17 ? 32  LEU A CA  1 
ATOM   215  C  C   . LEU A 1 32  ? 30.394 -10.296 9.316   1.00 46.11 ? 32  LEU A C   1 
ATOM   216  O  O   . LEU A 1 32  ? 29.198 -10.002 9.329   1.00 46.79 ? 32  LEU A O   1 
ATOM   217  C  CB  . LEU A 1 32  ? 29.971 -11.995 11.146  1.00 43.22 ? 32  LEU A CB  1 
ATOM   218  C  CG  . LEU A 1 32  ? 30.444 -13.174 11.993  1.00 42.95 ? 32  LEU A CG  1 
ATOM   219  C  CD1 . LEU A 1 32  ? 29.318 -13.590 12.918  1.00 45.57 ? 32  LEU A CD1 1 
ATOM   220  C  CD2 . LEU A 1 32  ? 30.895 -14.352 11.105  1.00 39.62 ? 32  LEU A CD2 1 
ATOM   221  N  N   . ARG A 1 33  ? 31.239 -9.808  8.421   1.00 42.56 ? 33  ARG A N   1 
ATOM   222  C  CA  . ARG A 1 33  ? 30.841 -8.871  7.380   1.00 44.92 ? 33  ARG A CA  1 
ATOM   223  C  C   . ARG A 1 33  ? 31.738 -9.125  6.183   1.00 50.25 ? 33  ARG A C   1 
ATOM   224  O  O   . ARG A 1 33  ? 32.851 -9.638  6.345   1.00 43.66 ? 33  ARG A O   1 
ATOM   225  C  CB  . ARG A 1 33  ? 30.997 -7.419  7.847   1.00 42.99 ? 33  ARG A CB  1 
ATOM   226  C  CG  . ARG A 1 33  ? 32.439 -7.032  8.112   1.00 47.63 ? 33  ARG A CG  1 
ATOM   227  C  CD  . ARG A 1 33  ? 32.561 -5.747  8.919   1.00 51.65 ? 33  ARG A CD  1 
ATOM   228  N  NE  . ARG A 1 33  ? 31.991 -4.621  8.192   1.00 58.07 ? 33  ARG A NE  1 
ATOM   229  C  CZ  . ARG A 1 33  ? 31.535 -3.516  8.764   1.00 54.78 ? 33  ARG A CZ  1 
ATOM   230  N  NH1 . ARG A 1 33  ? 31.630 -3.326  10.072  1.00 53.13 ? 33  ARG A NH1 1 
ATOM   231  N  NH2 . ARG A 1 33  ? 30.958 -2.584  8.006   1.00 55.46 ? 33  ARG A NH2 1 
ATOM   232  N  N   . PRO A 1 34  ? 31.299 -8.771  4.973   1.00 47.83 ? 34  PRO A N   1 
ATOM   233  C  CA  . PRO A 1 34  ? 32.192 -8.906  3.810   1.00 46.33 ? 34  PRO A CA  1 
ATOM   234  C  C   . PRO A 1 34  ? 33.489 -8.132  4.019   1.00 47.02 ? 34  PRO A C   1 
ATOM   235  O  O   . PRO A 1 34  ? 33.481 -6.982  4.445   1.00 42.37 ? 34  PRO A O   1 
ATOM   236  C  CB  . PRO A 1 34  ? 31.361 -8.319  2.662   1.00 50.19 ? 34  PRO A CB  1 
ATOM   237  C  CG  . PRO A 1 34  ? 29.951 -8.565  3.083   1.00 42.93 ? 34  PRO A CG  1 
ATOM   238  C  CD  . PRO A 1 34  ? 29.952 -8.326  4.572   1.00 46.48 ? 34  PRO A CD  1 
ATOM   239  N  N   . ARG A 1 35  ? 34.617 -8.779  3.719   1.00 40.43 ? 35  ARG A N   1 
ATOM   240  C  CA  . ARG A 1 35  ? 35.919 -8.190  3.971   1.00 41.55 ? 35  ARG A CA  1 
ATOM   241  C  C   . ARG A 1 35  ? 36.864 -8.600  2.846   1.00 46.13 ? 35  ARG A C   1 
ATOM   242  O  O   . ARG A 1 35  ? 37.926 -9.164  3.073   1.00 40.90 ? 35  ARG A O   1 
ATOM   243  C  CB  . ARG A 1 35  ? 36.476 -8.606  5.333   1.00 41.03 ? 35  ARG A CB  1 
ATOM   244  C  CG  . ARG A 1 35  ? 36.329 -10.101 5.638   1.00 41.46 ? 35  ARG A CG  1 
ATOM   245  C  CD  . ARG A 1 35  ? 36.200 -10.403 7.136   1.00 40.00 ? 35  ARG A CD  1 
ATOM   246  N  NE  . ARG A 1 35  ? 36.229 -11.849 7.336   1.00 36.76 ? 35  ARG A NE  1 
ATOM   247  C  CZ  . ARG A 1 35  ? 35.190 -12.646 7.143   1.00 39.59 ? 35  ARG A CZ  1 
ATOM   248  N  NH1 . ARG A 1 35  ? 33.999 -12.164 6.801   1.00 37.59 ? 35  ARG A NH1 1 
ATOM   249  N  NH2 . ARG A 1 35  ? 35.347 -13.961 7.270   1.00 38.98 ? 35  ARG A NH2 1 
ATOM   250  N  N   . VAL A 1 36  ? 36.453 -8.309  1.614   1.00 44.23 ? 36  VAL A N   1 
ATOM   251  C  CA  . VAL A 1 36  ? 37.269 -8.602  0.429   1.00 39.32 ? 36  VAL A CA  1 
ATOM   252  C  C   . VAL A 1 36  ? 38.496 -7.694  0.432   1.00 45.72 ? 36  VAL A C   1 
ATOM   253  O  O   . VAL A 1 36  ? 38.392 -6.531  0.866   1.00 41.14 ? 36  VAL A O   1 
ATOM   254  C  CB  . VAL A 1 36  ? 36.427 -8.414  -0.841  1.00 40.89 ? 36  VAL A CB  1 
ATOM   255  C  CG1 . VAL A 1 36  ? 37.249 -8.652  -2.102  1.00 39.94 ? 36  VAL A CG1 1 
ATOM   256  C  CG2 . VAL A 1 36  ? 35.214 -9.353  -0.804  1.00 41.89 ? 36  VAL A CG2 1 
ATOM   257  N  N   . PRO A 1 37  ? 39.680 -8.167  0.013   1.00 37.49 ? 37  PRO A N   1 
ATOM   258  C  CA  . PRO A 1 37  ? 40.864 -7.292  0.041   1.00 33.86 ? 37  PRO A CA  1 
ATOM   259  C  C   . PRO A 1 37  ? 40.649 -6.037  -0.795  1.00 40.28 ? 37  PRO A C   1 
ATOM   260  O  O   . PRO A 1 37  ? 40.046 -6.081  -1.865  1.00 43.45 ? 37  PRO A O   1 
ATOM   261  C  CB  . PRO A 1 37  ? 41.977 -8.172  -0.547  1.00 41.42 ? 37  PRO A CB  1 
ATOM   262  C  CG  . PRO A 1 37  ? 41.505 -9.590  -0.323  1.00 34.88 ? 37  PRO A CG  1 
ATOM   263  C  CD  . PRO A 1 37  ? 40.010 -9.558  -0.366  1.00 40.75 ? 37  PRO A CD  1 
ATOM   264  N  N   . GLY A 1 38  ? 41.150 -4.914  -0.289  1.00 40.44 ? 38  GLY A N   1 
ATOM   265  C  CA  . GLY A 1 38  ? 41.075 -3.645  -0.984  1.00 45.29 ? 38  GLY A CA  1 
ATOM   266  C  C   . GLY A 1 38  ? 39.772 -2.890  -0.827  1.00 46.58 ? 38  GLY A C   1 
ATOM   267  O  O   . GLY A 1 38  ? 39.694 -1.739  -1.269  1.00 48.42 ? 38  GLY A O   1 
ATOM   268  N  N   . THR A 1 39  ? 38.761 -3.483  -0.209  1.00 45.74 ? 39  THR A N   1 
ATOM   269  C  CA  . THR A 1 39  ? 37.446 -2.874  -0.053  1.00 45.56 ? 39  THR A CA  1 
ATOM   270  C  C   . THR A 1 39  ? 37.330 -2.148  1.280   1.00 50.33 ? 39  THR A C   1 
ATOM   271  O  O   . THR A 1 39  ? 38.145 -2.326  2.194   1.00 46.72 ? 39  THR A O   1 
ATOM   272  C  CB  . THR A 1 39  ? 36.373 -3.939  -0.144  1.00 42.39 ? 39  THR A CB  1 
ATOM   273  O  OG1 . THR A 1 39  ? 36.473 -4.814  0.991   1.00 45.83 ? 39  THR A OG1 1 
ATOM   274  C  CG2 . THR A 1 39  ? 36.493 -4.709  -1.437  1.00 44.34 ? 39  THR A CG2 1 
ATOM   275  N  N   . PRO A 1 40  ? 36.291 -1.317  1.442   1.00 48.51 ? 40  PRO A N   1 
ATOM   276  C  CA  . PRO A 1 40  ? 36.070 -0.700  2.762   1.00 45.86 ? 40  PRO A CA  1 
ATOM   277  C  C   . PRO A 1 40  ? 35.846 -1.718  3.877   1.00 41.84 ? 40  PRO A C   1 
ATOM   278  O  O   . PRO A 1 40  ? 36.312 -1.501  5.003   1.00 42.24 ? 40  PRO A O   1 
ATOM   279  C  CB  . PRO A 1 40  ? 34.833 0.186   2.529   1.00 44.64 ? 40  PRO A CB  1 
ATOM   280  C  CG  . PRO A 1 40  ? 34.187 -0.368  1.273   1.00 50.85 ? 40  PRO A CG  1 
ATOM   281  C  CD  . PRO A 1 40  ? 35.331 -0.820  0.432   1.00 49.69 ? 40  PRO A CD  1 
ATOM   282  N  N   . GLY A 1 41  ? 35.164 -2.833  3.597   1.00 48.33 ? 41  GLY A N   1 
ATOM   283  C  CA  . GLY A 1 41  ? 34.971 -3.845  4.628   1.00 46.97 ? 41  GLY A CA  1 
ATOM   284  C  C   . GLY A 1 41  ? 36.271 -4.442  5.145   1.00 43.29 ? 41  GLY A C   1 
ATOM   285  O  O   . GLY A 1 41  ? 36.380 -4.768  6.330   1.00 39.43 ? 41  GLY A O   1 
ATOM   286  N  N   . SER A 1 42  ? 37.270 -4.591  4.266   1.00 42.93 ? 42  SER A N   1 
ATOM   287  C  CA  . SER A 1 42  ? 38.596 -5.019  4.702   1.00 42.27 ? 42  SER A CA  1 
ATOM   288  C  C   . SER A 1 42  ? 39.199 -4.035  5.686   1.00 45.52 ? 42  SER A C   1 
ATOM   289  O  O   . SER A 1 42  ? 39.763 -4.437  6.704   1.00 39.74 ? 42  SER A O   1 
ATOM   290  C  CB  . SER A 1 42  ? 39.529 -5.192  3.499   1.00 44.51 ? 42  SER A CB  1 
ATOM   291  O  OG  . SER A 1 42  ? 40.881 -5.178  3.923   1.00 43.63 ? 42  SER A OG  1 
ATOM   292  N  N   . GLU A 1 43  ? 39.098 -2.732  5.408   1.00 41.37 ? 43  GLU A N   1 
ATOM   293  C  CA  . GLU A 1 43  ? 39.688 -1.766  6.324   1.00 38.62 ? 43  GLU A CA  1 
ATOM   294  C  C   . GLU A 1 43  ? 38.945 -1.724  7.653   1.00 37.99 ? 43  GLU A C   1 
ATOM   295  O  O   . GLU A 1 43  ? 39.566 -1.596  8.717   1.00 41.24 ? 43  GLU A O   1 
ATOM   296  C  CB  . GLU A 1 43  ? 39.723 -0.380  5.691   1.00 50.19 ? 43  GLU A CB  1 
ATOM   297  C  CG  . GLU A 1 43  ? 40.414 0.614   6.585   1.00 49.43 ? 43  GLU A CG  1 
ATOM   298  C  CD  . GLU A 1 43  ? 41.499 1.379   5.887   1.00 65.28 ? 43  GLU A CD  1 
ATOM   299  O  OE1 . GLU A 1 43  ? 41.559 1.326   4.635   1.00 62.22 ? 43  GLU A OE1 1 
ATOM   300  O  OE2 . GLU A 1 43  ? 42.290 2.042   6.604   1.00 72.83 ? 43  GLU A OE2 1 
ATOM   301  N  N   . LEU A 1 44  ? 37.624 -1.862  7.615   1.00 43.30 ? 44  LEU A N   1 
ATOM   302  C  CA  . LEU A 1 44  ? 36.864 -1.850  8.856   1.00 41.36 ? 44  LEU A CA  1 
ATOM   303  C  C   . LEU A 1 44  ? 37.230 -3.051  9.734   1.00 41.23 ? 44  LEU A C   1 
ATOM   304  O  O   . LEU A 1 44  ? 37.531 -2.889  10.923  1.00 40.07 ? 44  LEU A O   1 
ATOM   305  C  CB  . LEU A 1 44  ? 35.373 -1.828  8.544   1.00 46.96 ? 44  LEU A CB  1 
ATOM   306  C  CG  . LEU A 1 44  ? 34.831 -0.459  8.105   1.00 42.84 ? 44  LEU A CG  1 
ATOM   307  C  CD1 . LEU A 1 44  ? 33.433 -0.643  7.602   1.00 47.98 ? 44  LEU A CD1 1 
ATOM   308  C  CD2 . LEU A 1 44  ? 34.890 0.562   9.238   1.00 42.77 ? 44  LEU A CD2 1 
ATOM   309  N  N   . VAL A 1 45  ? 37.245 -4.260  9.158   1.00 43.12 ? 45  VAL A N   1 
ATOM   310  C  CA  . VAL A 1 45  ? 37.623 -5.443  9.938   1.00 36.48 ? 45  VAL A CA  1 
ATOM   311  C  C   . VAL A 1 45  ? 39.067 -5.325  10.436  1.00 37.13 ? 45  VAL A C   1 
ATOM   312  O  O   . VAL A 1 45  ? 39.359 -5.585  11.612  1.00 40.32 ? 45  VAL A O   1 
ATOM   313  C  CB  . VAL A 1 45  ? 37.412 -6.726  9.118   1.00 41.52 ? 45  VAL A CB  1 
ATOM   314  C  CG1 . VAL A 1 45  ? 38.162 -7.903  9.771   1.00 41.20 ? 45  VAL A CG1 1 
ATOM   315  C  CG2 . VAL A 1 45  ? 35.933 -7.053  8.997   1.00 40.18 ? 45  VAL A CG2 1 
ATOM   316  N  N   . ARG A 1 46  ? 40.000 -4.969  9.544   1.00 39.61 ? 46  ARG A N   1 
ATOM   317  C  CA  . ARG A 1 46  ? 41.397 -4.843  9.957   1.00 41.91 ? 46  ARG A CA  1 
ATOM   318  C  C   . ARG A 1 46  ? 41.548 -3.884  11.126  1.00 44.18 ? 46  ARG A C   1 
ATOM   319  O  O   . ARG A 1 46  ? 42.274 -4.170  12.091  1.00 44.34 ? 46  ARG A O   1 
ATOM   320  C  CB  . ARG A 1 46  ? 42.255 -4.389  8.770   1.00 40.88 ? 46  ARG A CB  1 
ATOM   321  C  CG  . ARG A 1 46  ? 43.663 -3.960  9.111   1.00 39.45 ? 46  ARG A CG  1 
ATOM   322  C  CD  . ARG A 1 46  ? 44.565 -3.946  7.857   1.00 38.87 ? 46  ARG A CD  1 
ATOM   323  N  NE  . ARG A 1 46  ? 44.186 -2.907  6.905   1.00 44.07 ? 46  ARG A NE  1 
ATOM   324  C  CZ  . ARG A 1 46  ? 43.496 -3.096  5.786   1.00 45.28 ? 46  ARG A CZ  1 
ATOM   325  N  NH1 . ARG A 1 46  ? 43.075 -4.294  5.422   1.00 42.58 ? 46  ARG A NH1 1 
ATOM   326  N  NH2 . ARG A 1 46  ? 43.237 -2.051  5.000   1.00 41.88 ? 46  ARG A NH2 1 
ATOM   327  N  N   . ASN A 1 47  ? 40.870 -2.736  11.075  1.00 45.27 ? 47  ASN A N   1 
ATOM   328  C  CA  . ASN A 1 47  ? 41.090 -1.782  12.151  1.00 40.38 ? 47  ASN A CA  1 
ATOM   329  C  C   . ASN A 1 47  ? 40.364 -2.216  13.422  1.00 36.89 ? 47  ASN A C   1 
ATOM   330  O  O   . ASN A 1 47  ? 40.828 -1.897  14.518  1.00 40.52 ? 47  ASN A O   1 
ATOM   331  C  CB  . ASN A 1 47  ? 40.704 -0.375  11.674  1.00 48.15 ? 47  ASN A CB  1 
ATOM   332  C  CG  . ASN A 1 47  ? 41.798 0.248   10.787  1.00 55.09 ? 47  ASN A CG  1 
ATOM   333  O  OD1 . ASN A 1 47  ? 41.568 0.586   9.614   1.00 58.43 ? 47  ASN A OD1 1 
ATOM   334  N  ND2 . ASN A 1 47  ? 43.000 0.385   11.350  1.00 51.89 ? 47  ASN A ND2 1 
ATOM   335  N  N   . TYR A 1 48  ? 39.289 -3.003  13.294  1.00 35.35 ? 48  TYR A N   1 
ATOM   336  C  CA  . TYR A 1 48  ? 38.679 -3.627  14.468  1.00 37.66 ? 48  TYR A CA  1 
ATOM   337  C  C   . TYR A 1 48  ? 39.681 -4.532  15.178  1.00 43.81 ? 48  TYR A C   1 
ATOM   338  O  O   . TYR A 1 48  ? 39.891 -4.423  16.390  1.00 41.85 ? 48  TYR A O   1 
ATOM   339  C  CB  . TYR A 1 48  ? 37.442 -4.436  14.071  1.00 38.04 ? 48  TYR A CB  1 
ATOM   340  C  CG  . TYR A 1 48  ? 36.996 -5.396  15.163  1.00 41.87 ? 48  TYR A CG  1 
ATOM   341  C  CD1 . TYR A 1 48  ? 36.535 -4.913  16.392  1.00 46.36 ? 48  TYR A CD1 1 
ATOM   342  C  CD2 . TYR A 1 48  ? 37.060 -6.778  14.984  1.00 40.78 ? 48  TYR A CD2 1 
ATOM   343  C  CE1 . TYR A 1 48  ? 36.140 -5.771  17.396  1.00 44.00 ? 48  TYR A CE1 1 
ATOM   344  C  CE2 . TYR A 1 48  ? 36.657 -7.661  15.993  1.00 36.99 ? 48  TYR A CE2 1 
ATOM   345  C  CZ  . TYR A 1 48  ? 36.196 -7.148  17.195  1.00 45.75 ? 48  TYR A CZ  1 
ATOM   346  O  OH  . TYR A 1 48  ? 35.795 -7.986  18.208  1.00 45.09 ? 48  TYR A OH  1 
ATOM   347  N  N   . ILE A 1 49  ? 40.326 -5.421  14.417  1.00 39.89 ? 49  ILE A N   1 
ATOM   348  C  CA  . ILE A 1 49  ? 41.341 -6.306  15.001  1.00 37.75 ? 49  ILE A CA  1 
ATOM   349  C  C   . ILE A 1 49  ? 42.468 -5.498  15.651  1.00 35.66 ? 49  ILE A C   1 
ATOM   350  O  O   . ILE A 1 49  ? 42.827 -5.733  16.815  1.00 38.70 ? 49  ILE A O   1 
ATOM   351  C  CB  . ILE A 1 49  ? 41.858 -7.300  13.944  1.00 34.72 ? 49  ILE A CB  1 
ATOM   352  C  CG1 . ILE A 1 49  ? 40.725 -8.253  13.586  1.00 32.61 ? 49  ILE A CG1 1 
ATOM   353  C  CG2 . ILE A 1 49  ? 43.080 -8.052  14.495  1.00 37.62 ? 49  ILE A CG2 1 
ATOM   354  C  CD1 . ILE A 1 49  ? 40.849 -9.030  12.254  1.00 37.48 ? 49  ILE A CD1 1 
ATOM   355  N  N   . ILE A 1 50  ? 43.044 -4.530  14.922  1.00 35.52 ? 50  ILE A N   1 
ATOM   356  C  CA  . ILE A 1 50  ? 44.131 -3.724  15.496  1.00 38.05 ? 50  ILE A CA  1 
ATOM   357  C  C   . ILE A 1 50  ? 43.682 -3.052  16.789  1.00 39.91 ? 50  ILE A C   1 
ATOM   358  O  O   . ILE A 1 50  ? 44.405 -3.049  17.794  1.00 39.37 ? 50  ILE A O   1 
ATOM   359  C  CB  . ILE A 1 50  ? 44.645 -2.674  14.493  1.00 42.41 ? 50  ILE A CB  1 
ATOM   360  C  CG1 . ILE A 1 50  ? 45.443 -3.339  13.373  1.00 40.84 ? 50  ILE A CG1 1 
ATOM   361  C  CG2 . ILE A 1 50  ? 45.542 -1.650  15.189  1.00 38.29 ? 50  ILE A CG2 1 
ATOM   362  C  CD1 . ILE A 1 50  ? 45.074 -2.817  12.021  1.00 48.54 ? 50  ILE A CD1 1 
ATOM   363  N  N   . GLN A 1 51  ? 42.479 -2.467  16.787  1.00 45.22 ? 51  GLN A N   1 
ATOM   364  C  CA  . GLN A 1 51  ? 42.015 -1.766  17.980  1.00 40.60 ? 51  GLN A CA  1 
ATOM   365  C  C   . GLN A 1 51  ? 41.776 -2.744  19.123  1.00 42.82 ? 51  GLN A C   1 
ATOM   366  O  O   . GLN A 1 51  ? 42.042 -2.428  20.285  1.00 42.92 ? 51  GLN A O   1 
ATOM   367  C  CB  . GLN A 1 51  ? 40.756 -0.958  17.649  1.00 47.70 ? 51  GLN A CB  1 
ATOM   368  C  CG  . GLN A 1 51  ? 41.097 0.358   16.945  1.00 48.12 ? 51  GLN A CG  1 
ATOM   369  C  CD  . GLN A 1 51  ? 42.231 1.087   17.656  1.00 50.14 ? 51  GLN A CD  1 
ATOM   370  O  OE1 . GLN A 1 51  ? 43.197 1.516   17.020  1.00 51.11 ? 51  GLN A OE1 1 
ATOM   371  N  NE2 . GLN A 1 51  ? 42.108 1.246   18.981  1.00 53.41 ? 51  GLN A NE2 1 
ATOM   372  N  N   . PHE A 1 52  ? 41.308 -3.952  18.808  1.00 45.93 ? 52  PHE A N   1 
ATOM   373  C  CA  . PHE A 1 52  ? 41.138 -4.950  19.857  1.00 40.94 ? 52  PHE A CA  1 
ATOM   374  C  C   . PHE A 1 52  ? 42.444 -5.200  20.569  1.00 40.94 ? 52  PHE A C   1 
ATOM   375  O  O   . PHE A 1 52  ? 42.501 -5.193  21.801  1.00 40.54 ? 52  PHE A O   1 
ATOM   376  C  CB  . PHE A 1 52  ? 40.587 -6.246  19.292  1.00 41.87 ? 52  PHE A CB  1 
ATOM   377  C  CG  . PHE A 1 52  ? 40.528 -7.359  20.296  1.00 46.17 ? 52  PHE A CG  1 
ATOM   378  C  CD1 . PHE A 1 52  ? 39.427 -7.494  21.120  1.00 45.61 ? 52  PHE A CD1 1 
ATOM   379  C  CD2 . PHE A 1 52  ? 41.552 -8.299  20.385  1.00 42.61 ? 52  PHE A CD2 1 
ATOM   380  C  CE1 . PHE A 1 52  ? 39.361 -8.517  22.044  1.00 49.27 ? 52  PHE A CE1 1 
ATOM   381  C  CE2 . PHE A 1 52  ? 41.485 -9.339  21.306  1.00 42.12 ? 52  PHE A CE2 1 
ATOM   382  C  CZ  . PHE A 1 52  ? 40.391 -9.446  22.135  1.00 45.25 ? 52  PHE A CZ  1 
ATOM   383  N  N   . PHE A 1 53  ? 43.518 -5.422  19.803  1.00 39.44 ? 53  PHE A N   1 
ATOM   384  C  CA  . PHE A 1 53  ? 44.809 -5.627  20.457  1.00 37.61 ? 53  PHE A CA  1 
ATOM   385  C  C   . PHE A 1 53  ? 45.266 -4.371  21.181  1.00 41.96 ? 53  PHE A C   1 
ATOM   386  O  O   . PHE A 1 53  ? 45.784 -4.441  22.300  1.00 37.26 ? 53  PHE A O   1 
ATOM   387  C  CB  . PHE A 1 53  ? 45.854 -6.102  19.437  1.00 40.76 ? 53  PHE A CB  1 
ATOM   388  C  CG  . PHE A 1 53  ? 45.755 -7.576  19.153  1.00 33.71 ? 53  PHE A CG  1 
ATOM   389  C  CD1 . PHE A 1 53  ? 44.856 -8.050  18.212  1.00 37.27 ? 53  PHE A CD1 1 
ATOM   390  C  CD2 . PHE A 1 53  ? 46.518 -8.491  19.872  1.00 35.64 ? 53  PHE A CD2 1 
ATOM   391  C  CE1 . PHE A 1 53  ? 44.733 -9.418  17.963  1.00 37.23 ? 53  PHE A CE1 1 
ATOM   392  C  CE2 . PHE A 1 53  ? 46.389 -9.856  19.635  1.00 29.26 ? 53  PHE A CE2 1 
ATOM   393  C  CZ  . PHE A 1 53  ? 45.514 -10.321 18.695  1.00 33.57 ? 53  PHE A CZ  1 
ATOM   394  N  N   . ASN A 1 54  ? 45.038 -3.206  20.590  1.00 38.65 ? 54  ASN A N   1 
ATOM   395  C  CA  . ASN A 1 54  ? 45.577 -1.994  21.188  1.00 40.72 ? 54  ASN A CA  1 
ATOM   396  C  C   . ASN A 1 54  ? 44.885 -1.659  22.509  1.00 41.24 ? 54  ASN A C   1 
ATOM   397  O  O   . ASN A 1 54  ? 45.531 -1.140  23.424  1.00 42.44 ? 54  ASN A O   1 
ATOM   398  C  CB  . ASN A 1 54  ? 45.467 -0.837  20.192  1.00 43.53 ? 54  ASN A CB  1 
ATOM   399  C  CG  . ASN A 1 54  ? 46.554 -0.886  19.119  1.00 51.11 ? 54  ASN A CG  1 
ATOM   400  O  OD1 . ASN A 1 54  ? 47.636 -1.468  19.321  1.00 47.02 ? 54  ASN A OD1 1 
ATOM   401  N  ND2 . ASN A 1 54  ? 46.285 -0.255  17.984  1.00 46.73 ? 54  ASN A ND2 1 
ATOM   402  N  N   . SER A 1 55  ? 43.593 -1.959  22.636  1.00 42.56 ? 55  SER A N   1 
ATOM   403  C  CA  . SER A 1 55  ? 42.903 -1.660  23.890  1.00 44.45 ? 55  SER A CA  1 
ATOM   404  C  C   . SER A 1 55  ? 43.005 -2.816  24.888  1.00 43.41 ? 55  SER A C   1 
ATOM   405  O  O   . SER A 1 55  ? 43.484 -2.623  26.011  1.00 41.52 ? 55  SER A O   1 
ATOM   406  C  CB  . SER A 1 55  ? 41.434 -1.296  23.645  1.00 38.17 ? 55  SER A CB  1 
ATOM   407  O  OG  . SER A 1 55  ? 40.732 -2.245  22.870  1.00 45.28 ? 55  SER A OG  1 
ATOM   408  N  N   . ALA A 1 56  ? 42.571 -4.024  24.490  1.00 46.14 ? 56  ALA A N   1 
ATOM   409  C  CA  . ALA A 1 56  ? 42.525 -5.146  25.433  1.00 41.47 ? 56  ALA A CA  1 
ATOM   410  C  C   . ALA A 1 56  ? 43.885 -5.792  25.684  1.00 48.03 ? 56  ALA A C   1 
ATOM   411  O  O   . ALA A 1 56  ? 44.076 -6.425  26.732  1.00 45.42 ? 56  ALA A O   1 
ATOM   412  C  CB  . ALA A 1 56  ? 41.554 -6.205  24.929  1.00 46.44 ? 56  ALA A CB  1 
ATOM   413  N  N   . LEU A 1 57  ? 44.837 -5.653  24.766  1.00 43.14 ? 57  LEU A N   1 
ATOM   414  C  CA  . LEU A 1 57  ? 46.157 -6.267  24.909  1.00 42.26 ? 57  LEU A CA  1 
ATOM   415  C  C   . LEU A 1 57  ? 47.247 -5.229  24.730  1.00 43.84 ? 57  LEU A C   1 
ATOM   416  O  O   . LEU A 1 57  ? 48.091 -5.336  23.833  1.00 43.35 ? 57  LEU A O   1 
ATOM   417  C  CB  . LEU A 1 57  ? 46.316 -7.414  23.914  1.00 41.51 ? 57  LEU A CB  1 
ATOM   418  C  CG  . LEU A 1 57  ? 45.359 -8.554  24.229  1.00 38.42 ? 57  LEU A CG  1 
ATOM   419  C  CD1 . LEU A 1 57  ? 45.214 -9.524  23.092  1.00 44.07 ? 57  LEU A CD1 1 
ATOM   420  C  CD2 . LEU A 1 57  ? 45.859 -9.259  25.485  1.00 46.22 ? 57  LEU A CD2 1 
ATOM   421  N  N   . PRO A 1 58  ? 47.290 -4.219  25.606  1.00 46.27 ? 58  PRO A N   1 
ATOM   422  C  CA  . PRO A 1 58  ? 48.156 -3.057  25.345  1.00 44.37 ? 58  PRO A CA  1 
ATOM   423  C  C   . PRO A 1 58  ? 49.635 -3.346  25.478  1.00 41.12 ? 58  PRO A C   1 
ATOM   424  O  O   . PRO A 1 58  ? 50.449 -2.535  25.027  1.00 43.98 ? 58  PRO A O   1 
ATOM   425  C  CB  . PRO A 1 58  ? 47.694 -2.038  26.397  1.00 45.30 ? 58  PRO A CB  1 
ATOM   426  C  CG  . PRO A 1 58  ? 47.164 -2.920  27.524  1.00 45.88 ? 58  PRO A CG  1 
ATOM   427  C  CD  . PRO A 1 58  ? 46.505 -4.063  26.846  1.00 46.75 ? 58  PRO A CD  1 
ATOM   428  N  N   . LEU A 1 59  ? 50.020 -4.459  26.098  1.00 45.57 ? 59  LEU A N   1 
ATOM   429  C  CA  . LEU A 1 59  ? 51.431 -4.801  26.166  1.00 39.79 ? 59  LEU A CA  1 
ATOM   430  C  C   . LEU A 1 59  ? 51.942 -5.411  24.861  1.00 41.14 ? 59  LEU A C   1 
ATOM   431  O  O   . LEU A 1 59  ? 53.156 -5.566  24.709  1.00 42.26 ? 59  LEU A O   1 
ATOM   432  C  CB  . LEU A 1 59  ? 51.659 -5.767  27.331  1.00 45.33 ? 59  LEU A CB  1 
ATOM   433  C  CG  . LEU A 1 59  ? 51.388 -5.112  28.695  1.00 38.62 ? 59  LEU A CG  1 
ATOM   434  C  CD1 . LEU A 1 59  ? 51.218 -6.129  29.784  1.00 41.32 ? 59  LEU A CD1 1 
ATOM   435  C  CD2 . LEU A 1 59  ? 52.505 -4.112  28.981  1.00 41.93 ? 59  LEU A CD2 1 
ATOM   436  N  N   . TRP A 1 60  ? 51.047 -5.749  23.928  1.00 42.87 ? 60  TRP A N   1 
ATOM   437  C  CA  . TRP A 1 60  ? 51.439 -6.282  22.624  1.00 43.06 ? 60  TRP A CA  1 
ATOM   438  C  C   . TRP A 1 60  ? 51.765 -5.170  21.623  1.00 46.15 ? 60  TRP A C   1 
ATOM   439  O  O   . TRP A 1 60  ? 51.071 -4.157  21.548  1.00 44.08 ? 60  TRP A O   1 
ATOM   440  C  CB  . TRP A 1 60  ? 50.315 -7.138  22.038  1.00 40.78 ? 60  TRP A CB  1 
ATOM   441  C  CG  . TRP A 1 60  ? 50.008 -8.405  22.772  1.00 39.97 ? 60  TRP A CG  1 
ATOM   442  C  CD1 . TRP A 1 60  ? 49.843 -8.562  24.123  1.00 41.82 ? 60  TRP A CD1 1 
ATOM   443  C  CD2 . TRP A 1 60  ? 49.826 -9.711  22.190  1.00 42.22 ? 60  TRP A CD2 1 
ATOM   444  N  NE1 . TRP A 1 60  ? 49.565 -9.880  24.416  1.00 38.39 ? 60  TRP A NE1 1 
ATOM   445  C  CE2 . TRP A 1 60  ? 49.555 -10.605 23.250  1.00 40.27 ? 60  TRP A CE2 1 
ATOM   446  C  CE3 . TRP A 1 60  ? 49.886 -10.211 20.878  1.00 39.12 ? 60  TRP A CE3 1 
ATOM   447  C  CZ2 . TRP A 1 60  ? 49.327 -11.969 23.041  1.00 36.04 ? 60  TRP A CZ2 1 
ATOM   448  C  CZ3 . TRP A 1 60  ? 49.648 -11.566 20.675  1.00 36.54 ? 60  TRP A CZ3 1 
ATOM   449  C  CH2 . TRP A 1 60  ? 49.382 -12.427 21.754  1.00 35.86 ? 60  TRP A CH2 1 
ATOM   450  N  N   . THR A 1 61  ? 52.751 -5.452  20.774  1.00 42.73 ? 61  THR A N   1 
ATOM   451  C  CA  . THR A 1 61  ? 53.089 -4.536  19.665  1.00 41.67 ? 61  THR A CA  1 
ATOM   452  C  C   . THR A 1 61  ? 52.352 -5.018  18.421  1.00 42.05 ? 61  THR A C   1 
ATOM   453  O  O   . THR A 1 61  ? 52.403 -6.218  18.141  1.00 43.89 ? 61  THR A O   1 
ATOM   454  C  CB  . THR A 1 61  ? 54.597 -4.529  19.400  1.00 42.65 ? 61  THR A CB  1 
ATOM   455  O  OG1 . THR A 1 61  ? 55.268 -3.979  20.532  1.00 44.11 ? 61  THR A OG1 1 
ATOM   456  C  CG2 . THR A 1 61  ? 54.966 -3.763  18.149  1.00 46.71 ? 61  THR A CG2 1 
ATOM   457  N  N   . THR A 1 62  ? 51.681 -4.113  17.720  1.00 40.68 ? 62  THR A N   1 
ATOM   458  C  CA  . THR A 1 62  ? 50.965 -4.464  16.475  1.00 40.52 ? 62  THR A CA  1 
ATOM   459  C  C   . THR A 1 62  ? 51.747 -3.914  15.274  1.00 44.71 ? 62  THR A C   1 
ATOM   460  O  O   . THR A 1 62  ? 52.398 -2.874  15.422  1.00 44.60 ? 62  THR A O   1 
ATOM   461  C  CB  . THR A 1 62  ? 49.513 -3.976  16.528  1.00 41.02 ? 62  THR A CB  1 
ATOM   462  O  OG1 . THR A 1 62  ? 49.513 -2.570  16.768  1.00 44.94 ? 62  THR A OG1 1 
ATOM   463  C  CG2 . THR A 1 62  ? 48.701 -4.676  17.594  1.00 44.18 ? 62  THR A CG2 1 
ATOM   464  N  N   . GLU A 1 63  ? 51.692 -4.617  14.148  1.00 43.85 ? 63  GLU A N   1 
ATOM   465  C  CA  . GLU A 1 63  ? 52.424 -4.200  12.933  1.00 44.29 ? 63  GLU A CA  1 
ATOM   466  C  C   . GLU A 1 63  ? 51.629 -4.637  11.716  1.00 44.26 ? 63  GLU A C   1 
ATOM   467  O  O   . GLU A 1 63  ? 50.838 -5.581  11.828  1.00 44.12 ? 63  GLU A O   1 
ATOM   468  C  CB  . GLU A 1 63  ? 53.761 -4.910  12.798  1.00 48.65 ? 63  GLU A CB  1 
ATOM   469  C  CG  . GLU A 1 63  ? 54.692 -4.758  13.979  1.00 54.02 ? 63  GLU A CG  1 
ATOM   470  C  CD  . GLU A 1 63  ? 56.086 -5.269  13.665  1.00 58.94 ? 63  GLU A CD  1 
ATOM   471  O  OE1 . GLU A 1 63  ? 56.201 -6.143  12.788  1.00 52.90 ? 63  GLU A OE1 1 
ATOM   472  O  OE2 . GLU A 1 63  ? 57.050 -4.780  14.285  1.00 68.99 ? 63  GLU A OE2 1 
ATOM   473  N  N   . LEU A 1 64  ? 51.835 -3.954  10.600  1.00 42.35 ? 64  LEU A N   1 
ATOM   474  C  CA  . LEU A 1 64  ? 51.178 -4.380  9.349   1.00 44.36 ? 64  LEU A CA  1 
ATOM   475  C  C   . LEU A 1 64  ? 52.253 -4.687  8.312   1.00 44.41 ? 64  LEU A C   1 
ATOM   476  O  O   . LEU A 1 64  ? 53.301 -4.035  8.332   1.00 43.05 ? 64  LEU A O   1 
ATOM   477  C  CB  . LEU A 1 64  ? 50.253 -3.265  8.867   1.00 47.71 ? 64  LEU A CB  1 
ATOM   478  C  CG  . LEU A 1 64  ? 49.086 -2.936  9.793   1.00 46.38 ? 64  LEU A CG  1 
ATOM   479  C  CD1 . LEU A 1 64  ? 48.396 -1.657  9.350   1.00 47.27 ? 64  LEU A CD1 1 
ATOM   480  C  CD2 . LEU A 1 64  ? 48.095 -4.084  9.840   1.00 38.89 ? 64  LEU A CD2 1 
ATOM   481  N  N   . GLN A 1 65  ? 52.017 -5.697  7.491   1.00 44.39 ? 65  GLN A N   1 
ATOM   482  C  CA  . GLN A 1 65  ? 52.948 -5.981  6.376   1.00 43.88 ? 65  GLN A CA  1 
ATOM   483  C  C   . GLN A 1 65  ? 52.124 -5.730  5.122   1.00 45.14 ? 65  GLN A C   1 
ATOM   484  O  O   . GLN A 1 65  ? 51.083 -6.378  4.970   1.00 44.23 ? 65  GLN A O   1 
ATOM   485  C  CB  . GLN A 1 65  ? 53.530 -7.390  6.443   1.00 42.28 ? 65  GLN A CB  1 
ATOM   486  C  CG  . GLN A 1 65  ? 54.622 -7.643  5.417   1.00 43.07 ? 65  GLN A CG  1 
ATOM   487  C  CD  . GLN A 1 65  ? 54.089 -8.281  4.159   1.00 43.02 ? 65  GLN A CD  1 
ATOM   488  O  OE1 . GLN A 1 65  ? 53.067 -8.956  4.168   1.00 41.68 ? 65  GLN A OE1 1 
ATOM   489  N  NE2 . GLN A 1 65  ? 54.784 -8.059  3.057   1.00 44.14 ? 65  GLN A NE2 1 
ATOM   490  N  N   . VAL A 1 66  ? 52.569 -4.794  4.289   1.00 47.15 ? 66  VAL A N   1 
ATOM   491  C  CA  . VAL A 1 66  ? 51.724 -4.407  3.131   1.00 41.23 ? 66  VAL A CA  1 
ATOM   492  C  C   . VAL A 1 66  ? 52.373 -4.754  1.801   1.00 43.43 ? 66  VAL A C   1 
ATOM   493  O  O   . VAL A 1 66  ? 53.557 -4.484  1.636   1.00 46.61 ? 66  VAL A O   1 
ATOM   494  C  CB  . VAL A 1 66  ? 51.402 -2.905  3.196   1.00 47.28 ? 66  VAL A CB  1 
ATOM   495  C  CG1 . VAL A 1 66  ? 50.478 -2.483  2.067   1.00 48.07 ? 66  VAL A CG1 1 
ATOM   496  C  CG2 . VAL A 1 66  ? 50.823 -2.514  4.544   1.00 41.94 ? 66  VAL A CG2 1 
ATOM   497  N  N   . SER A 1 67  ? 51.613 -5.384  0.922   1.00 44.91 ? 67  SER A N   1 
ATOM   498  C  CA  . SER A 1 67  ? 52.065 -5.597  -0.444  1.00 47.45 ? 67  SER A CA  1 
ATOM   499  C  C   . SER A 1 67  ? 50.898 -5.311  -1.372  1.00 44.74 ? 67  SER A C   1 
ATOM   500  O  O   . SER A 1 67  ? 49.787 -4.999  -0.926  1.00 48.49 ? 67  SER A O   1 
ATOM   501  C  CB  . SER A 1 67  ? 52.602 -7.016  -0.637  1.00 43.05 ? 67  SER A CB  1 
ATOM   502  O  OG  . SER A 1 67  ? 51.549 -7.955  -0.544  1.00 45.20 ? 67  SER A OG  1 
ATOM   503  N  N   . SER A 1 68  ? 51.145 -5.415  -2.674  1.00 46.74 ? 68  SER A N   1 
ATOM   504  C  CA  . SER A 1 68  ? 50.051 -5.352  -3.627  1.00 49.19 ? 68  SER A CA  1 
ATOM   505  C  C   . SER A 1 68  ? 50.371 -6.291  -4.770  1.00 46.48 ? 68  SER A C   1 
ATOM   506  O  O   . SER A 1 68  ? 51.537 -6.600  -5.042  1.00 49.21 ? 68  SER A O   1 
ATOM   507  C  CB  . SER A 1 68  ? 49.816 -3.931  -4.151  1.00 54.66 ? 68  SER A CB  1 
ATOM   508  O  OG  . SER A 1 68  ? 50.942 -3.469  -4.882  1.00 55.90 ? 68  SER A OG  1 
ATOM   509  N  N   . SER A 1 69  ? 49.320 -6.741  -5.435  1.00 43.04 ? 69  SER A N   1 
ATOM   510  C  CA  . SER A 1 69  ? 49.477 -7.735  -6.483  1.00 50.58 ? 69  SER A CA  1 
ATOM   511  C  C   . SER A 1 69  ? 48.278 -7.681  -7.417  1.00 52.67 ? 69  SER A C   1 
ATOM   512  O  O   . SER A 1 69  ? 47.156 -7.402  -6.985  1.00 48.77 ? 69  SER A O   1 
ATOM   513  C  CB  . SER A 1 69  ? 49.637 -9.137  -5.871  1.00 49.10 ? 69  SER A CB  1 
ATOM   514  O  OG  . SER A 1 69  ? 49.474 -10.156 -6.841  1.00 52.94 ? 69  SER A OG  1 
ATOM   515  N  N   . LYS A 1 70  ? 48.532 -7.909  -8.703  1.00 49.62 ? 70  LYS A N   1 
ATOM   516  C  CA  . LYS A 1 70  ? 47.455 -8.093  -9.658  1.00 49.34 ? 70  LYS A CA  1 
ATOM   517  C  C   . LYS A 1 70  ? 46.793 -9.441  -9.415  1.00 47.64 ? 70  LYS A C   1 
ATOM   518  O  O   . LYS A 1 70  ? 47.435 -10.397 -8.981  1.00 51.41 ? 70  LYS A O   1 
ATOM   519  C  CB  . LYS A 1 70  ? 47.997 -8.017  -11.087 1.00 52.83 ? 70  LYS A CB  1 
ATOM   520  C  CG  . LYS A 1 70  ? 48.109 -6.590  -11.626 1.00 58.11 ? 70  LYS A CG  1 
ATOM   521  C  CD  . LYS A 1 70  ? 48.589 -6.563  -13.082 1.00 61.17 ? 70  LYS A CD  1 
ATOM   522  C  CE  . LYS A 1 70  ? 49.941 -5.878  -13.219 1.00 63.77 ? 70  LYS A CE  1 
ATOM   523  N  NZ  . LYS A 1 70  ? 50.588 -6.196  -14.526 1.00 62.10 ? 70  LYS A NZ  1 
ATOM   524  N  N   . THR A 1 71  ? 45.500 -9.514  -9.663  1.00 44.70 ? 71  THR A N   1 
ATOM   525  C  CA  . THR A 1 71  ? 44.791 -10.779 -9.488  1.00 47.85 ? 71  THR A CA  1 
ATOM   526  C  C   . THR A 1 71  ? 44.108 -11.164 -10.793 1.00 50.49 ? 71  THR A C   1 
ATOM   527  O  O   . THR A 1 71  ? 44.021 -10.334 -11.704 1.00 50.67 ? 71  THR A O   1 
ATOM   528  C  CB  . THR A 1 71  ? 43.758 -10.693 -8.348  1.00 49.06 ? 71  THR A CB  1 
ATOM   529  O  OG1 . THR A 1 71  ? 42.502 -10.232 -8.859  1.00 50.81 ? 71  THR A OG1 1 
ATOM   530  C  CG2 . THR A 1 71  ? 44.230 -9.784  -7.213  1.00 44.61 ? 71  THR A CG2 1 
ATOM   531  N  N   . PRO A 1 72  ? 43.607 -12.397 -10.928 1.00 46.96 ? 72  PRO A N   1 
ATOM   532  C  CA  . PRO A 1 72  ? 42.877 -12.754 -12.154 1.00 50.07 ? 72  PRO A CA  1 
ATOM   533  C  C   . PRO A 1 72  ? 41.692 -11.845 -12.476 1.00 55.31 ? 72  PRO A C   1 
ATOM   534  O  O   . PRO A 1 72  ? 41.236 -11.846 -13.626 1.00 55.67 ? 72  PRO A O   1 
ATOM   535  C  CB  . PRO A 1 72  ? 42.404 -14.187 -11.875 1.00 51.09 ? 72  PRO A CB  1 
ATOM   536  C  CG  . PRO A 1 72  ? 43.420 -14.742 -10.952 1.00 48.65 ? 72  PRO A CG  1 
ATOM   537  C  CD  . PRO A 1 72  ? 43.890 -13.581 -10.095 1.00 47.67 ? 72  PRO A CD  1 
ATOM   538  N  N   . VAL A 1 73  ? 41.164 -11.086 -11.516 1.00 54.97 ? 73  VAL A N   1 
ATOM   539  C  CA  . VAL A 1 73  ? 39.972 -10.282 -11.757 1.00 54.94 ? 73  VAL A CA  1 
ATOM   540  C  C   . VAL A 1 73  ? 40.240 -8.788  -11.605 1.00 55.62 ? 73  VAL A C   1 
ATOM   541  O  O   . VAL A 1 73  ? 39.310 -7.987  -11.689 1.00 57.33 ? 73  VAL A O   1 
ATOM   542  C  CB  . VAL A 1 73  ? 38.801 -10.712 -10.848 1.00 50.99 ? 73  VAL A CB  1 
ATOM   543  C  CG1 . VAL A 1 73  ? 38.589 -12.222 -10.903 1.00 52.24 ? 73  VAL A CG1 1 
ATOM   544  C  CG2 . VAL A 1 73  ? 39.013 -10.208 -9.406  1.00 47.64 ? 73  VAL A CG2 1 
ATOM   545  N  N   . SER A 1 74  ? 41.488 -8.389  -11.392 1.00 49.84 ? 74  SER A N   1 
ATOM   546  C  CA  . SER A 1 74  ? 41.800 -6.984  -11.198 1.00 53.23 ? 74  SER A CA  1 
ATOM   547  C  C   . SER A 1 74  ? 42.316 -6.290  -12.459 1.00 55.81 ? 74  SER A C   1 
ATOM   548  O  O   . SER A 1 74  ? 42.636 -5.096  -12.398 1.00 54.69 ? 74  SER A O   1 
ATOM   549  C  CB  . SER A 1 74  ? 42.831 -6.816  -10.083 1.00 53.00 ? 74  SER A CB  1 
ATOM   550  O  OG  . SER A 1 74  ? 44.147 -6.978  -10.586 1.00 51.93 ? 74  SER A OG  1 
ATOM   551  N  N   . GLY A 1 75  ? 42.435 -7.005  -13.579 1.00 53.71 ? 75  GLY A N   1 
ATOM   552  C  CA  . GLY A 1 75  ? 42.951 -6.384  -14.792 1.00 51.43 ? 75  GLY A CA  1 
ATOM   553  C  C   . GLY A 1 75  ? 44.320 -5.779  -14.560 1.00 58.57 ? 75  GLY A C   1 
ATOM   554  O  O   . GLY A 1 75  ? 45.247 -6.441  -14.081 1.00 63.41 ? 75  GLY A O   1 
ATOM   555  N  N   . SER A 1 76  ? 44.450 -4.491  -14.873 1.00 58.41 ? 76  SER A N   1 
ATOM   556  C  CA  . SER A 1 76  ? 45.717 -3.786  -14.725 1.00 60.22 ? 76  SER A CA  1 
ATOM   557  C  C   . SER A 1 76  ? 45.962 -3.273  -13.313 1.00 59.04 ? 76  SER A C   1 
ATOM   558  O  O   . SER A 1 76  ? 47.090 -2.862  -13.014 1.00 63.03 ? 76  SER A O   1 
ATOM   559  C  CB  . SER A 1 76  ? 45.777 -2.607  -15.706 1.00 64.68 ? 76  SER A CB  1 
ATOM   560  O  OG  . SER A 1 76  ? 44.847 -1.585  -15.351 1.00 66.21 ? 76  SER A OG  1 
ATOM   561  N  N   . GLN A 1 77  ? 44.951 -3.284  -12.444 1.00 59.86 ? 77  GLN A N   1 
ATOM   562  C  CA  . GLN A 1 77  ? 45.051 -2.687  -11.113 1.00 60.80 ? 77  GLN A CA  1 
ATOM   563  C  C   . GLN A 1 77  ? 45.654 -3.655  -10.103 1.00 55.76 ? 77  GLN A C   1 
ATOM   564  O  O   . GLN A 1 77  ? 45.348 -4.849  -10.102 1.00 57.36 ? 77  GLN A O   1 
ATOM   565  C  CB  . GLN A 1 77  ? 43.677 -2.227  -10.618 1.00 63.17 ? 77  GLN A CB  1 
ATOM   566  C  CG  . GLN A 1 77  ? 42.922 -1.346  -11.613 1.00 67.79 ? 77  GLN A CG  1 
ATOM   567  C  CD  . GLN A 1 77  ? 43.538 0.039   -11.708 1.00 73.65 ? 77  GLN A CD  1 
ATOM   568  O  OE1 . GLN A 1 77  ? 44.178 0.387   -12.706 1.00 72.65 ? 77  GLN A OE1 1 
ATOM   569  N  NE2 . GLN A 1 77  ? 43.355 0.838   -10.656 1.00 74.11 ? 77  GLN A NE2 1 
ATOM   570  N  N   . ARG A 1 78  ? 46.501 -3.123  -9.234  1.00 54.24 ? 78  ARG A N   1 
ATOM   571  C  CA  . ARG A 1 78  ? 47.056 -3.888  -8.133  1.00 54.13 ? 78  ARG A CA  1 
ATOM   572  C  C   . ARG A 1 78  ? 46.099 -3.820  -6.953  1.00 54.53 ? 78  ARG A C   1 
ATOM   573  O  O   . ARG A 1 78  ? 45.606 -2.740  -6.606  1.00 54.91 ? 78  ARG A O   1 
ATOM   574  C  CB  . ARG A 1 78  ? 48.423 -3.331  -7.746  1.00 56.27 ? 78  ARG A CB  1 
ATOM   575  C  CG  . ARG A 1 78  ? 49.243 -2.916  -8.955  1.00 56.57 ? 78  ARG A CG  1 
ATOM   576  C  CD  . ARG A 1 78  ? 50.713 -2.972  -8.643  1.00 58.91 ? 78  ARG A CD  1 
ATOM   577  N  NE  . ARG A 1 78  ? 51.210 -4.278  -9.036  1.00 62.42 ? 78  ARG A NE  1 
ATOM   578  C  CZ  . ARG A 1 78  ? 52.045 -5.001  -8.307  1.00 59.90 ? 78  ARG A CZ  1 
ATOM   579  N  NH1 . ARG A 1 78  ? 52.600 -4.519  -7.212  1.00 60.02 ? 78  ARG A NH1 1 
ATOM   580  N  NH2 . ARG A 1 78  ? 52.290 -6.253  -8.661  1.00 55.08 ? 78  ARG A NH2 1 
ATOM   581  N  N   . ILE A 1 79  ? 45.816 -4.971  -6.365  1.00 47.27 ? 79  ILE A N   1 
ATOM   582  C  CA  . ILE A 1 79  ? 44.978 -5.079  -5.179  1.00 46.23 ? 79  ILE A CA  1 
ATOM   583  C  C   . ILE A 1 79  ? 45.908 -5.141  -3.971  1.00 49.55 ? 79  ILE A C   1 
ATOM   584  O  O   . ILE A 1 79  ? 46.893 -5.898  -4.009  1.00 51.53 ? 79  ILE A O   1 
ATOM   585  C  CB  . ILE A 1 79  ? 44.091 -6.329  -5.259  1.00 43.23 ? 79  ILE A CB  1 
ATOM   586  C  CG1 . ILE A 1 79  ? 43.049 -6.145  -6.358  1.00 50.15 ? 79  ILE A CG1 1 
ATOM   587  C  CG2 . ILE A 1 79  ? 43.359 -6.543  -3.936  1.00 41.43 ? 79  ILE A CG2 1 
ATOM   588  C  CD1 . ILE A 1 79  ? 41.963 -7.228  -6.392  1.00 51.32 ? 79  ILE A CD1 1 
ATOM   589  N  N   . PRO A 1 80  ? 45.678 -4.344  -2.923  1.00 49.33 ? 80  PRO A N   1 
ATOM   590  C  CA  . PRO A 1 80  ? 46.563 -4.397  -1.756  1.00 44.57 ? 80  PRO A CA  1 
ATOM   591  C  C   . PRO A 1 80  ? 46.195 -5.525  -0.800  1.00 45.86 ? 80  PRO A C   1 
ATOM   592  O  O   . PRO A 1 80  ? 45.028 -5.900  -0.645  1.00 43.78 ? 80  PRO A O   1 
ATOM   593  C  CB  . PRO A 1 80  ? 46.359 -3.025  -1.097  1.00 42.07 ? 80  PRO A CB  1 
ATOM   594  C  CG  . PRO A 1 80  ? 44.913 -2.716  -1.380  1.00 42.84 ? 80  PRO A CG  1 
ATOM   595  C  CD  . PRO A 1 80  ? 44.572 -3.381  -2.717  1.00 44.05 ? 80  PRO A CD  1 
ATOM   596  N  N   . PHE A 1 81  ? 47.227 -6.074  -0.160  1.00 41.08 ? 81  PHE A N   1 
ATOM   597  C  CA  . PHE A 1 81  ? 47.077 -7.158  0.809   1.00 40.37 ? 81  PHE A CA  1 
ATOM   598  C  C   . PHE A 1 81  ? 47.848 -6.770  2.064   1.00 39.63 ? 81  PHE A C   1 
ATOM   599  O  O   . PHE A 1 81  ? 49.040 -6.434  1.991   1.00 41.31 ? 81  PHE A O   1 
ATOM   600  C  CB  . PHE A 1 81  ? 47.568 -8.485  0.220   1.00 37.16 ? 81  PHE A CB  1 
ATOM   601  C  CG  . PHE A 1 81  ? 46.785 -8.926  -0.973  1.00 38.04 ? 81  PHE A CG  1 
ATOM   602  C  CD1 . PHE A 1 81  ? 45.586 -9.588  -0.815  1.00 35.28 ? 81  PHE A CD1 1 
ATOM   603  C  CD2 . PHE A 1 81  ? 47.243 -8.657  -2.265  1.00 41.22 ? 81  PHE A CD2 1 
ATOM   604  C  CE1 . PHE A 1 81  ? 44.855 -10.004 -1.929  1.00 41.08 ? 81  PHE A CE1 1 
ATOM   605  C  CE2 . PHE A 1 81  ? 46.521 -9.041  -3.373  1.00 40.66 ? 81  PHE A CE2 1 
ATOM   606  C  CZ  . PHE A 1 81  ? 45.327 -9.727  -3.218  1.00 39.83 ? 81  PHE A CZ  1 
ATOM   607  N  N   . VAL A 1 82  ? 47.151 -6.749  3.203   1.00 39.26 ? 82  VAL A N   1 
ATOM   608  C  CA  . VAL A 1 82  ? 47.660 -6.147  4.430   1.00 42.15 ? 82  VAL A CA  1 
ATOM   609  C  C   . VAL A 1 82  ? 47.574 -7.213  5.508   1.00 39.10 ? 82  VAL A C   1 
ATOM   610  O  O   . VAL A 1 82  ? 46.480 -7.509  6.002   1.00 36.96 ? 82  VAL A O   1 
ATOM   611  C  CB  . VAL A 1 82  ? 46.863 -4.898  4.838   1.00 38.28 ? 82  VAL A CB  1 
ATOM   612  C  CG1 . VAL A 1 82  ? 47.599 -4.128  5.950   1.00 41.28 ? 82  VAL A CG1 1 
ATOM   613  C  CG2 . VAL A 1 82  ? 46.594 -4.021  3.606   1.00 38.46 ? 82  VAL A CG2 1 
ATOM   614  N  N   . ASN A 1 83  ? 48.712 -7.797  5.872   1.00 40.64 ? 83  ASN A N   1 
ATOM   615  C  CA  . ASN A 1 83  ? 48.738 -8.757  6.963   1.00 38.56 ? 83  ASN A CA  1 
ATOM   616  C  C   . ASN A 1 83  ? 48.858 -8.016  8.275   1.00 33.77 ? 83  ASN A C   1 
ATOM   617  O  O   . ASN A 1 83  ? 49.552 -6.994  8.361   1.00 41.12 ? 83  ASN A O   1 
ATOM   618  C  CB  . ASN A 1 83  ? 49.918 -9.729  6.828   1.00 33.07 ? 83  ASN A CB  1 
ATOM   619  C  CG  . ASN A 1 83  ? 49.857 -10.534 5.584   1.00 33.93 ? 83  ASN A CG  1 
ATOM   620  O  OD1 . ASN A 1 83  ? 48.864 -11.213 5.312   1.00 34.79 ? 83  ASN A OD1 1 
ATOM   621  N  ND2 . ASN A 1 83  ? 50.933 -10.490 4.805   1.00 38.12 ? 83  ASN A ND2 1 
ATOM   622  N  N   . ILE A 1 84  ? 48.203 -8.555  9.305   1.00 35.38 ? 84  ILE A N   1 
ATOM   623  C  CA  . ILE A 1 84  ? 48.185 -7.972  10.639  1.00 32.53 ? 84  ILE A CA  1 
ATOM   624  C  C   . ILE A 1 84  ? 48.992 -8.862  11.559  1.00 33.39 ? 84  ILE A C   1 
ATOM   625  O  O   . ILE A 1 84  ? 48.687 -10.051 11.699  1.00 34.23 ? 84  ILE A O   1 
ATOM   626  C  CB  . ILE A 1 84  ? 46.756 -7.836  11.185  1.00 33.42 ? 84  ILE A CB  1 
ATOM   627  C  CG1 . ILE A 1 84  ? 45.830 -7.146  10.170  1.00 36.62 ? 84  ILE A CG1 1 
ATOM   628  C  CG2 . ILE A 1 84  ? 46.784 -7.165  12.533  1.00 37.13 ? 84  ILE A CG2 1 
ATOM   629  C  CD1 . ILE A 1 84  ? 44.398 -7.284  10.577  1.00 38.67 ? 84  ILE A CD1 1 
ATOM   630  N  N   . ILE A 1 85  ? 49.985 -8.286  12.216  1.00 36.97 ? 85  ILE A N   1 
ATOM   631  C  CA  . ILE A 1 85  ? 50.868 -9.010  13.109  1.00 38.62 ? 85  ILE A CA  1 
ATOM   632  C  C   . ILE A 1 85  ? 50.744 -8.398  14.492  1.00 39.02 ? 85  ILE A C   1 
ATOM   633  O  O   . ILE A 1 85  ? 50.810 -7.175  14.635  1.00 41.79 ? 85  ILE A O   1 
ATOM   634  C  CB  . ILE A 1 85  ? 52.320 -8.930  12.619  1.00 39.88 ? 85  ILE A CB  1 
ATOM   635  C  CG1 . ILE A 1 85  ? 52.425 -9.488  11.197  1.00 39.12 ? 85  ILE A CG1 1 
ATOM   636  C  CG2 . ILE A 1 85  ? 53.264 -9.636  13.593  1.00 42.84 ? 85  ILE A CG2 1 
ATOM   637  C  CD1 . ILE A 1 85  ? 52.937 -8.479  10.206  1.00 43.70 ? 85  ILE A CD1 1 
ATOM   638  N  N   . ALA A 1 86  ? 50.582 -9.233  15.512  1.00 34.51 ? 86  ALA A N   1 
ATOM   639  C  CA  . ALA A 1 86  ? 50.726 -8.730  16.872  1.00 36.11 ? 86  ALA A CA  1 
ATOM   640  C  C   . ALA A 1 86  ? 51.607 -9.673  17.668  1.00 39.41 ? 86  ALA A C   1 
ATOM   641  O  O   . ALA A 1 86  ? 51.484 -10.888 17.530  1.00 36.37 ? 86  ALA A O   1 
ATOM   642  C  CB  . ALA A 1 86  ? 49.365 -8.577  17.555  1.00 36.22 ? 86  ALA A CB  1 
ATOM   643  N  N   . TYR A 1 87  ? 52.457 -9.127  18.537  1.00 35.66 ? 87  TYR A N   1 
ATOM   644  C  CA  . TYR A 1 87  ? 53.336 -9.996  19.309  1.00 42.53 ? 87  TYR A CA  1 
ATOM   645  C  C   . TYR A 1 87  ? 53.605 -9.436  20.700  1.00 41.78 ? 87  TYR A C   1 
ATOM   646  O  O   . TYR A 1 87  ? 53.499 -8.230  20.938  1.00 44.13 ? 87  TYR A O   1 
ATOM   647  C  CB  . TYR A 1 87  ? 54.668 -10.247 18.583  1.00 41.20 ? 87  TYR A CB  1 
ATOM   648  C  CG  . TYR A 1 87  ? 55.481 -9.009  18.258  1.00 42.12 ? 87  TYR A CG  1 
ATOM   649  C  CD1 . TYR A 1 87  ? 56.395 -8.501  19.163  1.00 41.26 ? 87  TYR A CD1 1 
ATOM   650  C  CD2 . TYR A 1 87  ? 55.370 -8.383  17.021  1.00 46.82 ? 87  TYR A CD2 1 
ATOM   651  C  CE1 . TYR A 1 87  ? 57.157 -7.384  18.871  1.00 45.82 ? 87  TYR A CE1 1 
ATOM   652  C  CE2 . TYR A 1 87  ? 56.133 -7.250  16.721  1.00 47.29 ? 87  TYR A CE2 1 
ATOM   653  C  CZ  . TYR A 1 87  ? 57.026 -6.763  17.649  1.00 47.27 ? 87  TYR A CZ  1 
ATOM   654  O  OH  . TYR A 1 87  ? 57.800 -5.649  17.364  1.00 51.40 ? 87  TYR A OH  1 
ATOM   655  N  N   . ARG A 1 88  ? 53.918 -10.345 21.627  1.00 38.40 ? 88  ARG A N   1 
ATOM   656  C  CA  . ARG A 1 88  ? 54.396 -9.983  22.956  1.00 44.37 ? 88  ARG A CA  1 
ATOM   657  C  C   . ARG A 1 88  ? 55.519 -10.919 23.374  1.00 43.49 ? 88  ARG A C   1 
ATOM   658  O  O   . ARG A 1 88  ? 55.351 -12.148 23.366  1.00 42.79 ? 88  ARG A O   1 
ATOM   659  C  CB  . ARG A 1 88  ? 53.287 -10.035 24.004  1.00 43.43 ? 88  ARG A CB  1 
ATOM   660  C  CG  . ARG A 1 88  ? 53.585 -9.134  25.192  1.00 43.37 ? 88  ARG A CG  1 
ATOM   661  C  CD  . ARG A 1 88  ? 52.717 -9.497  26.365  1.00 41.53 ? 88  ARG A CD  1 
ATOM   662  N  NE  . ARG A 1 88  ? 53.328 -9.131  27.637  1.00 38.79 ? 88  ARG A NE  1 
ATOM   663  C  CZ  . ARG A 1 88  ? 52.783 -9.421  28.807  1.00 39.18 ? 88  ARG A CZ  1 
ATOM   664  N  NH1 . ARG A 1 88  ? 51.618 -10.047 28.888  1.00 41.78 ? 88  ARG A NH1 1 
ATOM   665  N  NH2 . ARG A 1 88  ? 53.416 -9.076  29.920  1.00 42.08 ? 88  ARG A NH2 1 
ATOM   666  N  N   . SER A 1 89  ? 56.635 -10.325 23.766  1.00 45.62 ? 89  SER A N   1 
ATOM   667  C  CA  . SER A 1 89  ? 57.878 -10.991 24.126  1.00 51.31 ? 89  SER A CA  1 
ATOM   668  C  C   . SER A 1 89  ? 58.222 -10.737 25.591  1.00 55.64 ? 89  SER A C   1 
ATOM   669  O  O   . SER A 1 89  ? 57.765 -9.746  26.177  1.00 47.93 ? 89  SER A O   1 
ATOM   670  C  CB  . SER A 1 89  ? 59.015 -10.487 23.225  1.00 46.37 ? 89  SER A CB  1 
ATOM   671  O  OG  . SER A 1 89  ? 59.535 -9.267  23.714  1.00 51.53 ? 89  SER A OG  1 
ATOM   672  N  N   . PRO A 1 90  ? 59.022 -11.613 26.215  1.00 53.01 ? 90  PRO A N   1 
ATOM   673  C  CA  . PRO A 1 90  ? 59.345 -11.427 27.635  1.00 55.58 ? 90  PRO A CA  1 
ATOM   674  C  C   . PRO A 1 90  ? 60.212 -10.199 27.830  1.00 59.17 ? 90  PRO A C   1 
ATOM   675  O  O   . PRO A 1 90  ? 61.000 -9.831  26.943  1.00 59.86 ? 90  PRO A O   1 
ATOM   676  C  CB  . PRO A 1 90  ? 60.110 -12.713 28.005  1.00 59.52 ? 90  PRO A CB  1 
ATOM   677  C  CG  . PRO A 1 90  ? 60.106 -13.591 26.825  1.00 58.25 ? 90  PRO A CG  1 
ATOM   678  C  CD  . PRO A 1 90  ? 59.503 -12.890 25.661  1.00 55.40 ? 90  PRO A CD  1 
ATOM   679  N  N   . PRO A 1 91  ? 60.121 -9.545  28.982  1.00 65.33 ? 91  PRO A N   1 
ATOM   680  C  CA  . PRO A 1 91  ? 60.723 -8.218  29.124  1.00 63.49 ? 91  PRO A CA  1 
ATOM   681  C  C   . PRO A 1 91  ? 62.221 -8.316  29.346  1.00 65.53 ? 91  PRO A C   1 
ATOM   682  O  O   . PRO A 1 91  ? 62.730 -9.295  29.895  1.00 68.60 ? 91  PRO A O   1 
ATOM   683  C  CB  . PRO A 1 91  ? 60.021 -7.650  30.358  1.00 64.70 ? 91  PRO A CB  1 
ATOM   684  C  CG  . PRO A 1 91  ? 59.627 -8.882  31.173  1.00 64.79 ? 91  PRO A CG  1 
ATOM   685  C  CD  . PRO A 1 91  ? 59.729 -10.103 30.288  1.00 65.92 ? 91  PRO A CD  1 
ATOM   686  N  N   . GLY A 1 92  ? 62.930 -7.280  28.901  1.00 63.06 ? 92  GLY A N   1 
ATOM   687  C  CA  . GLY A 1 92  ? 64.376 -7.309  29.011  1.00 69.31 ? 92  GLY A CA  1 
ATOM   688  C  C   . GLY A 1 92  ? 65.028 -8.413  28.215  1.00 70.22 ? 92  GLY A C   1 
ATOM   689  O  O   . GLY A 1 92  ? 66.138 -8.845  28.545  1.00 69.49 ? 92  GLY A O   1 
ATOM   690  N  N   . LEU A 1 93  ? 64.346 -8.910  27.193  1.00 68.54 ? 93  LEU A N   1 
ATOM   691  C  CA  . LEU A 1 93  ? 64.932 -9.795  26.202  1.00 64.00 ? 93  LEU A CA  1 
ATOM   692  C  C   . LEU A 1 93  ? 65.024 -9.063  24.879  1.00 63.20 ? 93  LEU A C   1 
ATOM   693  O  O   . LEU A 1 93  ? 64.099 -8.332  24.502  1.00 60.57 ? 93  LEU A O   1 
ATOM   694  C  CB  . LEU A 1 93  ? 64.100 -11.063 26.033  1.00 64.98 ? 93  LEU A CB  1 
ATOM   695  C  CG  . LEU A 1 93  ? 64.735 -12.335 26.564  1.00 67.11 ? 93  LEU A CG  1 
ATOM   696  C  CD1 . LEU A 1 93  ? 64.111 -13.503 25.848  1.00 64.32 ? 93  LEU A CD1 1 
ATOM   697  C  CD2 . LEU A 1 93  ? 66.233 -12.291 26.302  1.00 67.51 ? 93  LEU A CD2 1 
ATOM   698  N  N   . ASN A 1 94  ? 66.151 -9.242  24.193  1.00 62.95 ? 94  ASN A N   1 
ATOM   699  C  CA  . ASN A 1 94  ? 66.263 -8.783  22.815  1.00 59.12 ? 94  ASN A CA  1 
ATOM   700  C  C   . ASN A 1 94  ? 65.230 -9.503  21.971  1.00 55.78 ? 94  ASN A C   1 
ATOM   701  O  O   . ASN A 1 94  ? 65.207 -10.735 21.941  1.00 54.70 ? 94  ASN A O   1 
ATOM   702  C  CB  . ASN A 1 94  ? 67.663 -9.053  22.271  1.00 60.87 ? 94  ASN A CB  1 
ATOM   703  C  CG  . ASN A 1 94  ? 68.653 -8.021  22.714  1.00 62.82 ? 94  ASN A CG  1 
ATOM   704  O  OD1 . ASN A 1 94  ? 68.385 -7.260  23.638  1.00 61.91 ? 94  ASN A OD1 1 
ATOM   705  N  ND2 . ASN A 1 94  ? 69.801 -7.974  22.056  1.00 62.86 ? 94  ASN A ND2 1 
ATOM   706  N  N   . GLU A 1 95  ? 64.367 -8.738  21.300  1.00 49.73 ? 95  GLU A N   1 
ATOM   707  C  CA  . GLU A 1 95  ? 63.326 -9.363  20.498  1.00 54.16 ? 95  GLU A CA  1 
ATOM   708  C  C   . GLU A 1 95  ? 63.931 -10.284 19.454  1.00 53.48 ? 95  GLU A C   1 
ATOM   709  O  O   . GLU A 1 95  ? 63.399 -11.367 19.188  1.00 51.51 ? 95  GLU A O   1 
ATOM   710  C  CB  . GLU A 1 95  ? 62.446 -8.297  19.859  1.00 55.61 ? 95  GLU A CB  1 
ATOM   711  C  CG  . GLU A 1 95  ? 61.682 -7.536  20.927  1.00 58.76 ? 95  GLU A CG  1 
ATOM   712  C  CD  . GLU A 1 95  ? 60.386 -6.954  20.441  1.00 58.87 ? 95  GLU A CD  1 
ATOM   713  O  OE1 . GLU A 1 95  ? 60.318 -6.553  19.260  1.00 60.44 ? 95  GLU A OE1 1 
ATOM   714  O  OE2 . GLU A 1 95  ? 59.439 -6.890  21.258  1.00 64.30 ? 95  GLU A OE2 1 
ATOM   715  N  N   . THR A 1 96  ? 65.078 -9.906  18.906  1.00 51.79 ? 96  THR A N   1 
ATOM   716  C  CA  . THR A 1 96  ? 65.786 -10.767 17.967  1.00 52.41 ? 96  THR A CA  1 
ATOM   717  C  C   . THR A 1 96  ? 66.339 -12.054 18.597  1.00 53.38 ? 96  THR A C   1 
ATOM   718  O  O   . THR A 1 96  ? 66.865 -12.893 17.852  1.00 52.14 ? 96  THR A O   1 
ATOM   719  C  CB  . THR A 1 96  ? 66.912 -9.975  17.316  1.00 52.98 ? 96  THR A CB  1 
ATOM   720  O  OG1 . THR A 1 96  ? 67.582 -9.209  18.322  1.00 52.64 ? 96  THR A OG1 1 
ATOM   721  C  CG2 . THR A 1 96  ? 66.344 -9.028  16.275  1.00 53.12 ? 96  THR A CG2 1 
ATOM   722  N  N   . ASP A 1 97  ? 66.241 -12.263 19.915  1.00 52.06 ? 97  ASP A N   1 
ATOM   723  C  CA  . ASP A 1 97  ? 66.628 -13.541 20.512  1.00 50.30 ? 97  ASP A CA  1 
ATOM   724  C  C   . ASP A 1 97  ? 65.438 -14.412 20.899  1.00 48.86 ? 97  ASP A C   1 
ATOM   725  O  O   . ASP A 1 97  ? 65.631 -15.450 21.540  1.00 49.83 ? 97  ASP A O   1 
ATOM   726  C  CB  . ASP A 1 97  ? 67.510 -13.345 21.754  1.00 56.75 ? 97  ASP A CB  1 
ATOM   727  C  CG  . ASP A 1 97  ? 68.757 -12.528 21.483  1.00 58.95 ? 97  ASP A CG  1 
ATOM   728  O  OD1 . ASP A 1 97  ? 69.277 -12.561 20.345  1.00 62.96 ? 97  ASP A OD1 1 
ATOM   729  O  OD2 . ASP A 1 97  ? 69.247 -11.889 22.439  1.00 58.08 ? 97  ASP A OD2 1 
ATOM   730  N  N   . VAL A 1 98  ? 64.221 -14.033 20.502  1.00 50.71 ? 98  VAL A N   1 
ATOM   731  C  CA  . VAL A 1 98  ? 62.991 -14.688 20.940  1.00 45.24 ? 98  VAL A CA  1 
ATOM   732  C  C   . VAL A 1 98  ? 62.495 -15.669 19.887  1.00 41.50 ? 98  VAL A C   1 
ATOM   733  O  O   . VAL A 1 98  ? 62.457 -15.351 18.695  1.00 40.00 ? 98  VAL A O   1 
ATOM   734  C  CB  . VAL A 1 98  ? 61.916 -13.627 21.233  1.00 46.44 ? 98  VAL A CB  1 
ATOM   735  C  CG1 . VAL A 1 98  ? 60.662 -14.282 21.766  1.00 45.40 ? 98  VAL A CG1 1 
ATOM   736  C  CG2 . VAL A 1 98  ? 62.484 -12.570 22.192  1.00 49.77 ? 98  VAL A CG2 1 
ATOM   737  N  N   . GLY A 1 99  ? 62.089 -16.856 20.328  1.00 43.34 ? 99  GLY A N   1 
ATOM   738  C  CA  . GLY A 1 99  ? 61.354 -17.771 19.470  1.00 40.72 ? 99  GLY A CA  1 
ATOM   739  C  C   . GLY A 1 99  ? 59.868 -17.551 19.702  1.00 40.82 ? 99  GLY A C   1 
ATOM   740  O  O   . GLY A 1 99  ? 59.437 -17.324 20.829  1.00 39.03 ? 99  GLY A O   1 
ATOM   741  N  N   . TRP A 1 100 ? 59.085 -17.632 18.627  1.00 35.15 ? 100 TRP A N   1 
ATOM   742  C  CA  . TRP A 1 100 ? 57.678 -17.235 18.664  1.00 37.19 ? 100 TRP A CA  1 
ATOM   743  C  C   . TRP A 1 100 ? 56.757 -18.420 18.430  1.00 35.36 ? 100 TRP A C   1 
ATOM   744  O  O   . TRP A 1 100 ? 56.831 -19.078 17.385  1.00 36.00 ? 100 TRP A O   1 
ATOM   745  C  CB  . TRP A 1 100 ? 57.384 -16.152 17.623  1.00 34.85 ? 100 TRP A CB  1 
ATOM   746  C  CG  . TRP A 1 100 ? 58.264 -14.986 17.734  1.00 39.83 ? 100 TRP A CG  1 
ATOM   747  C  CD1 . TRP A 1 100 ? 59.399 -14.742 17.019  1.00 38.80 ? 100 TRP A CD1 1 
ATOM   748  C  CD2 . TRP A 1 100 ? 58.102 -13.880 18.620  1.00 40.26 ? 100 TRP A CD2 1 
ATOM   749  N  NE1 . TRP A 1 100 ? 59.967 -13.556 17.415  1.00 41.03 ? 100 TRP A NE1 1 
ATOM   750  C  CE2 . TRP A 1 100 ? 59.184 -13.004 18.399  1.00 39.63 ? 100 TRP A CE2 1 
ATOM   751  C  CE3 . TRP A 1 100 ? 57.146 -13.544 19.581  1.00 40.71 ? 100 TRP A CE3 1 
ATOM   752  C  CZ2 . TRP A 1 100 ? 59.327 -11.812 19.094  1.00 44.61 ? 100 TRP A CZ2 1 
ATOM   753  C  CZ3 . TRP A 1 100 ? 57.299 -12.373 20.276  1.00 40.16 ? 100 TRP A CZ3 1 
ATOM   754  C  CH2 . TRP A 1 100 ? 58.379 -11.517 20.032  1.00 43.34 ? 100 TRP A CH2 1 
ATOM   755  N  N   . LEU A 1 101 ? 55.844 -18.657 19.366  1.00 35.06 ? 101 LEU A N   1 
ATOM   756  C  CA  . LEU A 1 101 ? 54.677 -19.459 19.048  1.00 34.59 ? 101 LEU A CA  1 
ATOM   757  C  C   . LEU A 1 101 ? 53.761 -18.554 18.235  1.00 36.64 ? 101 LEU A C   1 
ATOM   758  O  O   . LEU A 1 101 ? 53.434 -17.450 18.680  1.00 38.28 ? 101 LEU A O   1 
ATOM   759  C  CB  . LEU A 1 101 ? 53.995 -19.966 20.314  1.00 35.90 ? 101 LEU A CB  1 
ATOM   760  C  CG  . LEU A 1 101 ? 52.623 -20.590 20.135  1.00 33.77 ? 101 LEU A CG  1 
ATOM   761  C  CD1 . LEU A 1 101 ? 52.638 -21.860 19.285  1.00 33.61 ? 101 LEU A CD1 1 
ATOM   762  C  CD2 . LEU A 1 101 ? 52.028 -20.898 21.475  1.00 33.19 ? 101 LEU A CD2 1 
ATOM   763  N  N   . THR A 1 102 ? 53.407 -18.977 17.028  1.00 32.36 ? 102 THR A N   1 
ATOM   764  C  CA  . THR A 1 102 ? 52.768 -18.095 16.059  1.00 35.15 ? 102 THR A CA  1 
ATOM   765  C  C   . THR A 1 102 ? 51.429 -18.690 15.679  1.00 35.29 ? 102 THR A C   1 
ATOM   766  O  O   . THR A 1 102 ? 51.365 -19.780 15.104  1.00 31.80 ? 102 THR A O   1 
ATOM   767  C  CB  . THR A 1 102 ? 53.662 -17.924 14.836  1.00 33.58 ? 102 THR A CB  1 
ATOM   768  O  OG1 . THR A 1 102 ? 54.853 -17.244 15.241  1.00 32.14 ? 102 THR A OG1 1 
ATOM   769  C  CG2 . THR A 1 102 ? 52.959 -17.161 13.750  1.00 32.06 ? 102 THR A CG2 1 
ATOM   770  N  N   . LEU A 1 103 ? 50.356 -17.989 16.005  1.00 30.46 ? 103 LEU A N   1 
ATOM   771  C  CA  . LEU A 1 103 ? 49.009 -18.453 15.728  1.00 26.02 ? 103 LEU A CA  1 
ATOM   772  C  C   . LEU A 1 103 ? 48.405 -17.650 14.573  1.00 30.42 ? 103 LEU A C   1 
ATOM   773  O  O   . LEU A 1 103 ? 48.499 -16.420 14.576  1.00 32.42 ? 103 LEU A O   1 
ATOM   774  C  CB  . LEU A 1 103 ? 48.143 -18.263 16.973  1.00 31.43 ? 103 LEU A CB  1 
ATOM   775  C  CG  . LEU A 1 103 ? 48.650 -18.787 18.310  1.00 33.14 ? 103 LEU A CG  1 
ATOM   776  C  CD1 . LEU A 1 103 ? 47.637 -18.435 19.376  1.00 29.14 ? 103 LEU A CD1 1 
ATOM   777  C  CD2 . LEU A 1 103 ? 48.823 -20.329 18.211  1.00 30.46 ? 103 LEU A CD2 1 
ATOM   778  N  N   . VAL A 1 104 ? 47.780 -18.333 13.597  1.00 32.90 ? 104 VAL A N   1 
ATOM   779  C  CA  . VAL A 1 104 ? 47.427 -17.731 12.307  1.00 29.28 ? 104 VAL A CA  1 
ATOM   780  C  C   . VAL A 1 104 ? 46.000 -18.074 11.891  1.00 31.78 ? 104 VAL A C   1 
ATOM   781  O  O   . VAL A 1 104 ? 45.520 -19.196 12.091  1.00 29.90 ? 104 VAL A O   1 
ATOM   782  C  CB  . VAL A 1 104 ? 48.419 -18.170 11.204  1.00 32.01 ? 104 VAL A CB  1 
ATOM   783  C  CG1 . VAL A 1 104 ? 48.183 -17.371 9.933   1.00 31.99 ? 104 VAL A CG1 1 
ATOM   784  C  CG2 . VAL A 1 104 ? 49.856 -17.993 11.698  1.00 29.31 ? 104 VAL A CG2 1 
ATOM   785  N  N   . ALA A 1 105 ? 45.329 -17.107 11.253  1.00 30.84 ? 105 ALA A N   1 
ATOM   786  C  CA  . ALA A 1 105 ? 44.102 -17.372 10.519  1.00 28.03 ? 105 ALA A CA  1 
ATOM   787  C  C   . ALA A 1 105 ? 43.971 -16.276 9.470   1.00 26.44 ? 105 ALA A C   1 
ATOM   788  O  O   . ALA A 1 105 ? 44.579 -15.218 9.609   1.00 31.29 ? 105 ALA A O   1 
ATOM   789  C  CB  . ALA A 1 105 ? 42.872 -17.399 11.430  1.00 31.71 ? 105 ALA A CB  1 
ATOM   790  N  N   . HIS A 1 106 ? 43.213 -16.546 8.411   1.00 26.99 ? 106 HIS A N   1 
ATOM   791  C  CA  . HIS A 1 106 ? 43.017 -15.509 7.398   1.00 30.97 ? 106 HIS A CA  1 
ATOM   792  C  C   . HIS A 1 106 ? 41.761 -14.714 7.720   1.00 31.73 ? 106 HIS A C   1 
ATOM   793  O  O   . HIS A 1 106 ? 40.731 -15.278 8.093   1.00 30.97 ? 106 HIS A O   1 
ATOM   794  C  CB  . HIS A 1 106 ? 42.956 -16.058 5.968   1.00 31.85 ? 106 HIS A CB  1 
ATOM   795  C  CG  . HIS A 1 106 ? 41.635 -16.631 5.555   1.00 33.45 ? 106 HIS A CG  1 
ATOM   796  N  ND1 . HIS A 1 106 ? 40.682 -15.906 4.864   1.00 33.29 ? 106 HIS A ND1 1 
ATOM   797  C  CD2 . HIS A 1 106 ? 41.140 -17.881 5.673   1.00 27.39 ? 106 HIS A CD2 1 
ATOM   798  C  CE1 . HIS A 1 106 ? 39.652 -16.684 4.590   1.00 33.43 ? 106 HIS A CE1 1 
ATOM   799  N  NE2 . HIS A 1 106 ? 39.901 -17.889 5.068   1.00 33.30 ? 106 HIS A NE2 1 
ATOM   800  N  N   . TYR A 1 107 ? 41.869 -13.400 7.576   1.00 34.88 ? 107 TYR A N   1 
ATOM   801  C  CA  . TYR A 1 107 ? 40.742 -12.511 7.822   1.00 34.92 ? 107 TYR A CA  1 
ATOM   802  C  C   . TYR A 1 107 ? 40.096 -11.959 6.564   1.00 40.29 ? 107 TYR A C   1 
ATOM   803  O  O   . TYR A 1 107 ? 39.040 -11.328 6.667   1.00 38.70 ? 107 TYR A O   1 
ATOM   804  C  CB  . TYR A 1 107 ? 41.174 -11.349 8.722   1.00 31.62 ? 107 TYR A CB  1 
ATOM   805  C  CG  . TYR A 1 107 ? 41.915 -10.205 8.048   1.00 38.26 ? 107 TYR A CG  1 
ATOM   806  C  CD1 . TYR A 1 107 ? 43.297 -10.230 7.918   1.00 36.15 ? 107 TYR A CD1 1 
ATOM   807  C  CD2 . TYR A 1 107 ? 41.236 -9.065  7.584   1.00 36.82 ? 107 TYR A CD2 1 
ATOM   808  C  CE1 . TYR A 1 107 ? 43.997 -9.189  7.310   1.00 36.53 ? 107 TYR A CE1 1 
ATOM   809  C  CE2 . TYR A 1 107 ? 41.937 -8.001  6.986   1.00 36.81 ? 107 TYR A CE2 1 
ATOM   810  C  CZ  . TYR A 1 107 ? 43.303 -8.065  6.849   1.00 37.38 ? 107 TYR A CZ  1 
ATOM   811  O  OH  . TYR A 1 107 ? 44.017 -7.042  6.269   1.00 39.70 ? 107 TYR A OH  1 
ATOM   812  N  N   . ASP A 1 108 ? 40.674 -12.170 5.391   1.00 33.42 ? 108 ASP A N   1 
ATOM   813  C  CA  . ASP A 1 108 ? 39.973 -11.806 4.163   1.00 35.62 ? 108 ASP A CA  1 
ATOM   814  C  C   . ASP A 1 108 ? 38.785 -12.734 3.918   1.00 39.86 ? 108 ASP A C   1 
ATOM   815  O  O   . ASP A 1 108 ? 38.689 -13.831 4.476   1.00 36.04 ? 108 ASP A O   1 
ATOM   816  C  CB  . ASP A 1 108 ? 40.932 -11.853 2.970   1.00 36.43 ? 108 ASP A CB  1 
ATOM   817  C  CG  . ASP A 1 108 ? 41.416 -13.266 2.672   1.00 39.75 ? 108 ASP A CG  1 
ATOM   818  O  OD1 . ASP A 1 108 ? 41.991 -13.910 3.591   1.00 38.32 ? 108 ASP A OD1 1 
ATOM   819  O  OD2 . ASP A 1 108 ? 41.214 -13.729 1.539   1.00 34.16 ? 108 ASP A OD2 1 
ATOM   820  N  N   . SER A 1 109 ? 37.851 -12.287 3.075   1.00 37.16 ? 109 SER A N   1 
ATOM   821  C  CA  . SER A 1 109 ? 36.758 -13.157 2.666   1.00 34.23 ? 109 SER A CA  1 
ATOM   822  C  C   . SER A 1 109 ? 36.737 -13.318 1.152   1.00 35.15 ? 109 SER A C   1 
ATOM   823  O  O   . SER A 1 109 ? 37.242 -12.479 0.401   1.00 38.07 ? 109 SER A O   1 
ATOM   824  C  CB  . SER A 1 109 ? 35.390 -12.657 3.172   1.00 42.70 ? 109 SER A CB  1 
ATOM   825  O  OG  . SER A 1 109 ? 35.187 -11.303 2.843   1.00 39.09 ? 109 SER A OG  1 
ATOM   826  N  N   . LEU A 1 110 ? 36.157 -14.439 0.734   1.00 35.48 ? 110 LEU A N   1 
ATOM   827  C  CA  . LEU A 1 110 ? 35.975 -14.779 -0.689  1.00 38.88 ? 110 LEU A CA  1 
ATOM   828  C  C   . LEU A 1 110 ? 35.200 -13.658 -1.361  1.00 46.30 ? 110 LEU A C   1 
ATOM   829  O  O   . LEU A 1 110 ? 34.284 -13.066 -0.783  1.00 47.31 ? 110 LEU A O   1 
ATOM   830  C  CB  . LEU A 1 110 ? 35.148 -16.066 -0.742  1.00 40.57 ? 110 LEU A CB  1 
ATOM   831  C  CG  . LEU A 1 110 ? 35.745 -17.261 -1.481  1.00 46.54 ? 110 LEU A CG  1 
ATOM   832  C  CD1 . LEU A 1 110 ? 34.637 -18.097 -2.098  1.00 48.34 ? 110 LEU A CD1 1 
ATOM   833  C  CD2 . LEU A 1 110 ? 36.727 -16.819 -2.550  1.00 45.14 ? 110 LEU A CD2 1 
ATOM   834  N  N   . LYS A 1 111 ? 35.542 -13.413 -2.625  1.00 40.08 ? 111 LYS A N   1 
ATOM   835  C  CA  . LYS A 1 111 ? 34.892 -12.330 -3.367  1.00 47.45 ? 111 LYS A CA  1 
ATOM   836  C  C   . LYS A 1 111 ? 33.593 -12.767 -4.056  1.00 50.51 ? 111 LYS A C   1 
ATOM   837  O  O   . LYS A 1 111 ? 32.612 -12.012 -4.059  1.00 56.55 ? 111 LYS A O   1 
ATOM   838  C  CB  . LYS A 1 111 ? 35.867 -11.732 -4.383  1.00 44.41 ? 111 LYS A CB  1 
ATOM   839  C  CG  . LYS A 1 111 ? 35.376 -10.416 -5.018  1.00 51.22 ? 111 LYS A CG  1 
ATOM   840  C  CD  . LYS A 1 111 ? 36.365 -9.882  -6.051  1.00 50.39 ? 111 LYS A CD  1 
ATOM   841  C  CE  . LYS A 1 111 ? 35.930 -8.549  -6.675  1.00 57.13 ? 111 LYS A CE  1 
ATOM   842  N  NZ  . LYS A 1 111 ? 35.479 -8.734  -8.077  1.00 53.14 ? 111 LYS A NZ  1 
ATOM   843  N  N   . ASP A 1 112 ? 33.545 -13.973 -4.620  1.00 49.30 ? 112 ASP A N   1 
ATOM   844  C  CA  . ASP A 1 112 ? 32.361 -14.507 -5.284  1.00 55.50 ? 112 ASP A CA  1 
ATOM   845  C  C   . ASP A 1 112 ? 31.828 -15.662 -4.454  1.00 53.89 ? 112 ASP A C   1 
ATOM   846  O  O   . ASP A 1 112 ? 32.585 -16.595 -4.165  1.00 56.60 ? 112 ASP A O   1 
ATOM   847  C  CB  . ASP A 1 112 ? 32.736 -14.962 -6.727  1.00 51.98 ? 112 ASP A CB  1 
ATOM   848  C  CG  . ASP A 1 112 ? 31.727 -15.932 -7.388  1.00 58.34 ? 112 ASP A CG  1 
ATOM   849  O  OD1 . ASP A 1 112 ? 30.659 -16.272 -6.835  1.00 66.80 ? 112 ASP A OD1 1 
ATOM   850  O  OD2 . ASP A 1 112 ? 32.017 -16.372 -8.523  1.00 53.06 ? 112 ASP A OD2 1 
ATOM   851  N  N   . PRO A 1 113 ? 30.550 -15.663 -4.050  1.00 58.15 ? 113 PRO A N   1 
ATOM   852  C  CA  . PRO A 1 113 ? 29.477 -14.721 -4.395  1.00 58.94 ? 113 PRO A CA  1 
ATOM   853  C  C   . PRO A 1 113 ? 29.532 -13.414 -3.613  1.00 56.63 ? 113 PRO A C   1 
ATOM   854  O  O   . PRO A 1 113 ? 30.076 -13.370 -2.509  1.00 55.10 ? 113 PRO A O   1 
ATOM   855  C  CB  . PRO A 1 113 ? 28.210 -15.529 -4.076  1.00 55.54 ? 113 PRO A CB  1 
ATOM   856  C  CG  . PRO A 1 113 ? 28.613 -16.437 -2.967  1.00 56.99 ? 113 PRO A CG  1 
ATOM   857  C  CD  . PRO A 1 113 ? 30.046 -16.791 -3.243  1.00 56.00 ? 113 PRO A CD  1 
ATOM   858  N  N   . GLU A 1 114 ? 28.986 -12.337 -4.190  1.00 57.82 ? 114 GLU A N   1 
ATOM   859  C  CA  . GLU A 1 114 ? 28.857 -11.060 -3.491  1.00 58.50 ? 114 GLU A CA  1 
ATOM   860  C  C   . GLU A 1 114 ? 28.172 -11.245 -2.143  1.00 52.67 ? 114 GLU A C   1 
ATOM   861  O  O   . GLU A 1 114 ? 27.203 -12.000 -2.015  1.00 54.70 ? 114 GLU A O   1 
ATOM   862  C  CB  . GLU A 1 114 ? 28.059 -10.071 -4.348  1.00 60.29 ? 114 GLU A CB  1 
ATOM   863  C  CG  . GLU A 1 114 ? 28.888 -9.077  -5.165  1.00 67.83 ? 114 GLU A CG  1 
ATOM   864  C  CD  . GLU A 1 114 ? 29.036 -7.705  -4.502  1.00 72.71 ? 114 GLU A CD  1 
ATOM   865  O  OE1 . GLU A 1 114 ? 28.965 -7.623  -3.258  1.00 69.36 ? 114 GLU A OE1 1 
ATOM   866  O  OE2 . GLU A 1 114 ? 29.223 -6.703  -5.236  1.00 76.36 ? 114 GLU A OE2 1 
ATOM   867  N  N   . GLY A 1 115 ? 28.691 -10.553 -1.132  1.00 46.81 ? 115 GLY A N   1 
ATOM   868  C  CA  . GLY A 1 115 ? 28.165 -10.644 0.211   1.00 48.97 ? 115 GLY A CA  1 
ATOM   869  C  C   . GLY A 1 115 ? 28.608 -11.846 1.019   1.00 48.42 ? 115 GLY A C   1 
ATOM   870  O  O   . GLY A 1 115 ? 28.169 -11.985 2.165   1.00 41.49 ? 115 GLY A O   1 
ATOM   871  N  N   . PHE A 1 116 ? 29.466 -12.715 0.473   1.00 48.71 ? 116 PHE A N   1 
ATOM   872  C  CA  . PHE A 1 116 ? 29.894 -13.912 1.196   1.00 45.37 ? 116 PHE A CA  1 
ATOM   873  C  C   . PHE A 1 116 ? 30.467 -13.541 2.563   1.00 38.13 ? 116 PHE A C   1 
ATOM   874  O  O   . PHE A 1 116 ? 31.241 -12.590 2.688   1.00 44.65 ? 116 PHE A O   1 
ATOM   875  C  CB  . PHE A 1 116 ? 30.928 -14.680 0.357   1.00 45.93 ? 116 PHE A CB  1 
ATOM   876  C  CG  . PHE A 1 116 ? 31.447 -15.928 1.023   1.00 42.27 ? 116 PHE A CG  1 
ATOM   877  C  CD1 . PHE A 1 116 ? 30.702 -17.090 1.027   1.00 45.23 ? 116 PHE A CD1 1 
ATOM   878  C  CD2 . PHE A 1 116 ? 32.677 -15.920 1.645   1.00 41.10 ? 116 PHE A CD2 1 
ATOM   879  C  CE1 . PHE A 1 116 ? 31.189 -18.241 1.633   1.00 46.46 ? 116 PHE A CE1 1 
ATOM   880  C  CE2 . PHE A 1 116 ? 33.171 -17.054 2.261   1.00 42.34 ? 116 PHE A CE2 1 
ATOM   881  C  CZ  . PHE A 1 116 ? 32.435 -18.220 2.258   1.00 41.16 ? 116 PHE A CZ  1 
ATOM   882  N  N   . ILE A 1 117 ? 30.058 -14.273 3.597   1.00 38.60 ? 117 ILE A N   1 
ATOM   883  C  CA  . ILE A 1 117 ? 30.453 -13.964 4.968   1.00 39.27 ? 117 ILE A CA  1 
ATOM   884  C  C   . ILE A 1 117 ? 31.651 -14.801 5.427   1.00 42.47 ? 117 ILE A C   1 
ATOM   885  O  O   . ILE A 1 117 ? 32.550 -14.287 6.096   1.00 38.60 ? 117 ILE A O   1 
ATOM   886  C  CB  . ILE A 1 117 ? 29.260 -14.132 5.937   1.00 41.25 ? 117 ILE A CB  1 
ATOM   887  C  CG1 . ILE A 1 117 ? 28.177 -13.084 5.629   1.00 41.53 ? 117 ILE A CG1 1 
ATOM   888  C  CG2 . ILE A 1 117 ? 29.699 -13.945 7.367   1.00 38.49 ? 117 ILE A CG2 1 
ATOM   889  C  CD1 . ILE A 1 117 ? 28.648 -11.649 5.945   1.00 47.24 ? 117 ILE A CD1 1 
ATOM   890  N  N   . GLY A 1 118 ? 31.682 -16.090 5.105   1.00 44.98 ? 118 GLY A N   1 
ATOM   891  C  CA  . GLY A 1 118 ? 32.769 -16.928 5.602   1.00 42.61 ? 118 GLY A CA  1 
ATOM   892  C  C   . GLY A 1 118 ? 32.866 -16.928 7.116   1.00 38.62 ? 118 GLY A C   1 
ATOM   893  O  O   . GLY A 1 118 ? 33.857 -16.469 7.698   1.00 38.88 ? 118 GLY A O   1 
ATOM   894  N  N   . ALA A 1 119 ? 31.814 -17.414 7.774   1.00 36.09 ? 119 ALA A N   1 
ATOM   895  C  CA  . ALA A 1 119 ? 31.807 -17.386 9.230   1.00 38.00 ? 119 ALA A CA  1 
ATOM   896  C  C   . ALA A 1 119 ? 32.818 -18.381 9.805   1.00 36.63 ? 119 ALA A C   1 
ATOM   897  O  O   . ALA A 1 119 ? 33.472 -18.079 10.805  1.00 36.50 ? 119 ALA A O   1 
ATOM   898  C  CB  . ALA A 1 119 ? 30.411 -17.676 9.755   1.00 42.07 ? 119 ALA A CB  1 
ATOM   899  N  N   . ILE A 1 120 ? 32.934 -19.578 9.203   1.00 41.00 ? 120 ILE A N   1 
ATOM   900  C  CA  . ILE A 1 120 ? 33.998 -20.522 9.583   1.00 39.93 ? 120 ILE A CA  1 
ATOM   901  C  C   . ILE A 1 120 ? 35.271 -20.271 8.795   1.00 39.82 ? 120 ILE A C   1 
ATOM   902  O  O   . ILE A 1 120 ? 36.344 -20.786 9.166   1.00 38.26 ? 120 ILE A O   1 
ATOM   903  C  CB  . ILE A 1 120 ? 33.572 -21.998 9.409   1.00 41.11 ? 120 ILE A CB  1 
ATOM   904  C  CG1 . ILE A 1 120 ? 33.585 -22.445 7.946   1.00 40.28 ? 120 ILE A CG1 1 
ATOM   905  C  CG2 . ILE A 1 120 ? 32.231 -22.267 10.060  1.00 43.85 ? 120 ILE A CG2 1 
ATOM   906  C  CD1 . ILE A 1 120 ? 33.359 -23.939 7.768   1.00 41.29 ? 120 ILE A CD1 1 
ATOM   907  N  N   . ASP A 1 121 ? 35.212 -19.430 7.780   1.00 35.58 ? 121 ASP A N   1 
ATOM   908  C  CA  . ASP A 1 121 ? 36.261 -19.301 6.777   1.00 36.71 ? 121 ASP A CA  1 
ATOM   909  C  C   . ASP A 1 121 ? 36.625 -17.822 6.576   1.00 35.43 ? 121 ASP A C   1 
ATOM   910  O  O   . ASP A 1 121 ? 36.292 -17.239 5.538   1.00 36.70 ? 121 ASP A O   1 
ATOM   911  C  CB  . ASP A 1 121 ? 35.772 -19.925 5.491   1.00 38.03 ? 121 ASP A CB  1 
ATOM   912  C  CG  . ASP A 1 121 ? 36.798 -19.918 4.391   1.00 37.52 ? 121 ASP A CG  1 
ATOM   913  O  OD1 . ASP A 1 121 ? 37.946 -19.468 4.616   1.00 35.94 ? 121 ASP A OD1 1 
ATOM   914  O  OD2 . ASP A 1 121 ? 36.408 -20.351 3.286   1.00 39.26 ? 121 ASP A OD2 1 
ATOM   915  N  N   . SER A 1 122 ? 37.341 -17.231 7.532   1.00 32.02 ? 122 SER A N   1 
ATOM   916  C  CA  . SER A 1 122 ? 37.803 -17.807 8.788   1.00 36.33 ? 122 SER A CA  1 
ATOM   917  C  C   . SER A 1 122 ? 37.548 -16.838 9.891   1.00 35.04 ? 122 SER A C   1 
ATOM   918  O  O   . SER A 1 122 ? 38.401 -16.594 10.733  1.00 31.29 ? 122 SER A O   1 
ATOM   919  C  CB  . SER A 1 122 ? 39.306 -18.165 8.720   1.00 33.34 ? 122 SER A CB  1 
ATOM   920  O  OG  . SER A 1 122 ? 39.432 -19.279 7.887   1.00 33.14 ? 122 SER A OG  1 
ATOM   921  N  N   . ALA A 1 123 ? 36.354 -16.240 9.889   1.00 36.18 ? 123 ALA A N   1 
ATOM   922  C  CA  . ALA A 1 123 ? 36.032 -15.303 10.952  1.00 32.47 ? 123 ALA A CA  1 
ATOM   923  C  C   . ALA A 1 123 ? 36.123 -15.980 12.308  1.00 28.49 ? 123 ALA A C   1 
ATOM   924  O  O   . ALA A 1 123 ? 36.749 -15.461 13.236  1.00 32.99 ? 123 ALA A O   1 
ATOM   925  C  CB  . ALA A 1 123 ? 34.615 -14.720 10.735  1.00 35.08 ? 123 ALA A CB  1 
ATOM   926  N  N   . ALA A 1 124 ? 35.487 -17.132 12.440  1.00 34.57 ? 124 ALA A N   1 
ATOM   927  C  CA  . ALA A 1 124 ? 35.515 -17.810 13.730  1.00 35.48 ? 124 ALA A CA  1 
ATOM   928  C  C   . ALA A 1 124 ? 36.936 -18.186 14.118  1.00 35.66 ? 124 ALA A C   1 
ATOM   929  O  O   . ALA A 1 124 ? 37.320 -17.910 15.264  1.00 34.67 ? 124 ALA A O   1 
ATOM   930  C  CB  . ALA A 1 124 ? 34.564 -19.007 13.713  1.00 33.33 ? 124 ALA A CB  1 
ATOM   931  N  N   . PRO A 1 125 ? 37.768 -18.783 13.237  1.00 35.66 ? 125 PRO A N   1 
ATOM   932  C  CA  . PRO A 1 125 ? 39.193 -18.962 13.595  1.00 33.86 ? 125 PRO A CA  1 
ATOM   933  C  C   . PRO A 1 125 ? 39.847 -17.687 14.137  1.00 33.07 ? 125 PRO A C   1 
ATOM   934  O  O   . PRO A 1 125 ? 40.569 -17.720 15.145  1.00 32.46 ? 125 PRO A O   1 
ATOM   935  C  CB  . PRO A 1 125 ? 39.811 -19.428 12.260  1.00 33.81 ? 125 PRO A CB  1 
ATOM   936  C  CG  . PRO A 1 125 ? 38.729 -20.279 11.617  1.00 30.91 ? 125 PRO A CG  1 
ATOM   937  C  CD  . PRO A 1 125 ? 37.401 -19.531 12.018  1.00 31.49 ? 125 PRO A CD  1 
ATOM   938  N  N   . CYS A 1 126 ? 39.584 -16.540 13.496  1.00 34.21 ? 126 CYS A N   1 
ATOM   939  C  CA  . CYS A 1 126 ? 40.170 -15.288 13.961  1.00 29.37 ? 126 CYS A CA  1 
ATOM   940  C  C   . CYS A 1 126 ? 39.702 -14.959 15.370  1.00 30.98 ? 126 CYS A C   1 
ATOM   941  O  O   . CYS A 1 126 ? 40.488 -14.500 16.209  1.00 34.29 ? 126 CYS A O   1 
ATOM   942  C  CB  . CYS A 1 126 ? 39.816 -14.146 13.001  1.00 33.83 ? 126 CYS A CB  1 
ATOM   943  S  SG  . CYS A 1 126 ? 40.592 -14.184 11.362  1.00 33.99 ? 126 CYS A SG  1 
ATOM   944  N  N   . SER A 1 127 ? 38.421 -15.179 15.648  1.00 34.39 ? 127 SER A N   1 
ATOM   945  C  CA  . SER A 1 127 ? 37.956 -14.872 16.996  1.00 34.97 ? 127 SER A CA  1 
ATOM   946  C  C   . SER A 1 127 ? 38.514 -15.865 18.013  1.00 35.89 ? 127 SER A C   1 
ATOM   947  O  O   . SER A 1 127 ? 38.746 -15.496 19.161  1.00 35.17 ? 127 SER A O   1 
ATOM   948  C  CB  . SER A 1 127 ? 36.438 -14.860 17.041  1.00 38.91 ? 127 SER A CB  1 
ATOM   949  O  OG  . SER A 1 127 ? 35.934 -16.161 16.888  1.00 36.40 ? 127 SER A OG  1 
ATOM   950  N  N   . ILE A 1 128 ? 38.722 -17.120 17.606  1.00 36.31 ? 128 ILE A N   1 
ATOM   951  C  CA  . ILE A 1 128 ? 39.327 -18.114 18.499  1.00 34.12 ? 128 ILE A CA  1 
ATOM   952  C  C   . ILE A 1 128 ? 40.716 -17.666 18.922  1.00 37.28 ? 128 ILE A C   1 
ATOM   953  O  O   . ILE A 1 128 ? 41.079 -17.711 20.108  1.00 38.91 ? 128 ILE A O   1 
ATOM   954  C  CB  . ILE A 1 128 ? 39.363 -19.492 17.815  1.00 38.92 ? 128 ILE A CB  1 
ATOM   955  C  CG1 . ILE A 1 128 ? 37.947 -20.038 17.732  1.00 33.51 ? 128 ILE A CG1 1 
ATOM   956  C  CG2 . ILE A 1 128 ? 40.320 -20.422 18.561  1.00 35.60 ? 128 ILE A CG2 1 
ATOM   957  C  CD1 . ILE A 1 128 ? 37.719 -21.028 16.676  1.00 31.09 ? 128 ILE A CD1 1 
ATOM   958  N  N   . ILE A 1 129 ? 41.510 -17.191 17.958  1.00 33.81 ? 129 ILE A N   1 
ATOM   959  C  CA  . ILE A 1 129 ? 42.844 -16.718 18.296  1.00 33.43 ? 129 ILE A CA  1 
ATOM   960  C  C   . ILE A 1 129 ? 42.766 -15.511 19.212  1.00 33.87 ? 129 ILE A C   1 
ATOM   961  O  O   . ILE A 1 129 ? 43.490 -15.398 20.205  1.00 29.56 ? 129 ILE A O   1 
ATOM   962  C  CB  . ILE A 1 129 ? 43.631 -16.397 17.019  1.00 30.21 ? 129 ILE A CB  1 
ATOM   963  C  CG1 . ILE A 1 129 ? 43.947 -17.702 16.318  1.00 30.09 ? 129 ILE A CG1 1 
ATOM   964  C  CG2 . ILE A 1 129 ? 44.871 -15.629 17.355  1.00 29.61 ? 129 ILE A CG2 1 
ATOM   965  C  CD1 . ILE A 1 129 ? 44.579 -17.520 14.953  1.00 33.93 ? 129 ILE A CD1 1 
ATOM   966  N  N   . MET A 1 130 ? 41.908 -14.558 18.863  1.00 35.97 ? 130 MET A N   1 
ATOM   967  C  CA  . MET A 1 130 ? 41.807 -13.330 19.644  1.00 30.37 ? 130 MET A CA  1 
ATOM   968  C  C   . MET A 1 130 ? 41.435 -13.651 21.092  1.00 30.58 ? 130 MET A C   1 
ATOM   969  O  O   . MET A 1 130 ? 42.070 -13.182 22.049  1.00 36.83 ? 130 MET A O   1 
ATOM   970  C  CB  . MET A 1 130 ? 40.734 -12.491 18.952  1.00 34.20 ? 130 MET A CB  1 
ATOM   971  C  CG  . MET A 1 130 ? 41.211 -11.923 17.634  1.00 36.99 ? 130 MET A CG  1 
ATOM   972  S  SD  . MET A 1 130 ? 39.880 -11.093 16.724  1.00 40.34 ? 130 MET A SD  1 
ATOM   973  C  CE  . MET A 1 130 ? 40.044 -9.494  17.480  1.00 36.29 ? 130 MET A CE  1 
ATOM   974  N  N   . SER A 1 131 ? 40.421 -14.492 21.259  1.00 37.44 ? 131 SER A N   1 
ATOM   975  C  CA  . SER A 1 131 ? 39.959 -14.869 22.584  1.00 37.21 ? 131 SER A CA  1 
ATOM   976  C  C   . SER A 1 131 ? 41.056 -15.581 23.358  1.00 38.42 ? 131 SER A C   1 
ATOM   977  O  O   . SER A 1 131 ? 41.328 -15.263 24.526  1.00 35.62 ? 131 SER A O   1 
ATOM   978  C  CB  . SER A 1 131 ? 38.726 -15.752 22.420  1.00 39.48 ? 131 SER A CB  1 
ATOM   979  O  OG  . SER A 1 131 ? 38.289 -16.301 23.644  1.00 47.49 ? 131 SER A OG  1 
ATOM   980  N  N   . ALA A 1 132 ? 41.759 -16.495 22.695  1.00 38.34 ? 132 ALA A N   1 
ATOM   981  C  CA  . ALA A 1 132 ? 42.748 -17.298 23.401  1.00 35.08 ? 132 ALA A CA  1 
ATOM   982  C  C   . ALA A 1 132 ? 43.926 -16.455 23.868  1.00 32.29 ? 132 ALA A C   1 
ATOM   983  O  O   . ALA A 1 132 ? 44.401 -16.598 25.002  1.00 37.96 ? 132 ALA A O   1 
ATOM   984  C  CB  . ALA A 1 132 ? 43.200 -18.428 22.484  1.00 34.26 ? 132 ALA A CB  1 
ATOM   985  N  N   . VAL A 1 133 ? 44.461 -15.598 22.997  1.00 31.55 ? 133 VAL A N   1 
ATOM   986  C  CA  . VAL A 1 133 ? 45.608 -14.830 23.469  1.00 34.95 ? 133 VAL A CA  1 
ATOM   987  C  C   . VAL A 1 133 ? 45.177 -13.829 24.541  1.00 36.27 ? 133 VAL A C   1 
ATOM   988  O  O   . VAL A 1 133 ? 45.969 -13.474 25.434  1.00 33.86 ? 133 VAL A O   1 
ATOM   989  C  CB  . VAL A 1 133 ? 46.358 -14.161 22.301  1.00 32.83 ? 133 VAL A CB  1 
ATOM   990  C  CG1 . VAL A 1 133 ? 46.979 -15.265 21.376  1.00 32.07 ? 133 VAL A CG1 1 
ATOM   991  C  CG2 . VAL A 1 133 ? 45.440 -13.212 21.522  1.00 34.05 ? 133 VAL A CG2 1 
ATOM   992  N  N   . ARG A 1 134 ? 43.915 -13.389 24.512  1.00 39.92 ? 134 ARG A N   1 
ATOM   993  C  CA  . ARG A 1 134 ? 43.441 -12.573 25.630  1.00 37.69 ? 134 ARG A CA  1 
ATOM   994  C  C   . ARG A 1 134 ? 43.515 -13.358 26.934  1.00 39.01 ? 134 ARG A C   1 
ATOM   995  O  O   . ARG A 1 134 ? 44.011 -12.861 27.952  1.00 42.77 ? 134 ARG A O   1 
ATOM   996  C  CB  . ARG A 1 134 ? 42.005 -12.104 25.370  1.00 42.86 ? 134 ARG A CB  1 
ATOM   997  C  CG  . ARG A 1 134 ? 41.797 -10.626 25.623  1.00 47.34 ? 134 ARG A CG  1 
ATOM   998  C  CD  . ARG A 1 134 ? 40.461 -10.354 26.263  1.00 52.40 ? 134 ARG A CD  1 
ATOM   999  N  NE  . ARG A 1 134 ? 40.656 -9.395  27.343  1.00 61.19 ? 134 ARG A NE  1 
ATOM   1000 C  CZ  . ARG A 1 134 ? 39.811 -8.422  27.661  1.00 64.62 ? 134 ARG A CZ  1 
ATOM   1001 N  NH1 . ARG A 1 134 ? 38.660 -8.269  27.026  1.00 59.71 ? 134 ARG A NH1 1 
ATOM   1002 N  NH2 . ARG A 1 134 ? 40.136 -7.578  28.639  1.00 61.12 ? 134 ARG A NH2 1 
ATOM   1003 N  N   . SER A 1 135 ? 43.059 -14.609 26.908  1.00 41.72 ? 135 SER A N   1 
ATOM   1004 C  CA  . SER A 1 135 ? 43.093 -15.402 28.131  1.00 44.15 ? 135 SER A CA  1 
ATOM   1005 C  C   . SER A 1 135 ? 44.523 -15.647 28.610  1.00 45.17 ? 135 SER A C   1 
ATOM   1006 O  O   . SER A 1 135 ? 44.785 -15.597 29.814  1.00 53.63 ? 135 SER A O   1 
ATOM   1007 C  CB  . SER A 1 135 ? 42.341 -16.716 27.940  1.00 45.75 ? 135 SER A CB  1 
ATOM   1008 O  OG  . SER A 1 135 ? 41.188 -16.545 27.118  1.00 51.50 ? 135 SER A OG  1 
ATOM   1009 N  N   . ILE A 1 136 ? 45.476 -15.895 27.699  1.00 38.45 ? 136 ILE A N   1 
ATOM   1010 C  CA  . ILE A 1 136 ? 46.822 -16.205 28.204  1.00 44.28 ? 136 ILE A CA  1 
ATOM   1011 C  C   . ILE A 1 136 ? 47.674 -14.984 28.526  1.00 47.73 ? 136 ILE A C   1 
ATOM   1012 O  O   . ILE A 1 136 ? 48.737 -15.128 29.160  1.00 41.82 ? 136 ILE A O   1 
ATOM   1013 C  CB  . ILE A 1 136 ? 47.679 -17.094 27.276  1.00 48.46 ? 136 ILE A CB  1 
ATOM   1014 C  CG1 . ILE A 1 136 ? 48.240 -16.302 26.107  1.00 41.93 ? 136 ILE A CG1 1 
ATOM   1015 C  CG2 . ILE A 1 136 ? 46.947 -18.358 26.813  1.00 42.16 ? 136 ILE A CG2 1 
ATOM   1016 C  CD1 . ILE A 1 136 ? 49.510 -16.909 25.594  1.00 47.48 ? 136 ILE A CD1 1 
ATOM   1017 N  N   . ASP A 1 137 ? 47.256 -13.784 28.116  1.00 44.67 ? 137 ASP A N   1 
ATOM   1018 C  CA  . ASP A 1 137 ? 48.072 -12.604 28.373  1.00 41.39 ? 137 ASP A CA  1 
ATOM   1019 C  C   . ASP A 1 137 ? 48.236 -12.346 29.874  1.00 40.31 ? 137 ASP A C   1 
ATOM   1020 O  O   . ASP A 1 137 ? 49.328 -11.977 30.334  1.00 42.54 ? 137 ASP A O   1 
ATOM   1021 C  CB  . ASP A 1 137 ? 47.438 -11.414 27.649  1.00 39.56 ? 137 ASP A CB  1 
ATOM   1022 C  CG  . ASP A 1 137 ? 48.243 -10.152 27.751  1.00 43.20 ? 137 ASP A CG  1 
ATOM   1023 O  OD1 . ASP A 1 137 ? 49.276 -10.040 27.080  1.00 43.69 ? 137 ASP A OD1 1 
ATOM   1024 O  OD2 . ASP A 1 137 ? 47.805 -9.234  28.461  1.00 46.84 ? 137 ASP A OD2 1 
ATOM   1025 N  N   . ALA A 1 138 ? 47.174 -12.547 30.657  1.00 37.78 ? 138 ALA A N   1 
ATOM   1026 C  CA  . ALA A 1 138 ? 47.285 -12.320 32.098  1.00 47.32 ? 138 ALA A CA  1 
ATOM   1027 C  C   . ALA A 1 138 ? 48.265 -13.299 32.731  1.00 46.94 ? 138 ALA A C   1 
ATOM   1028 O  O   . ALA A 1 138 ? 49.080 -12.924 33.590  1.00 40.48 ? 138 ALA A O   1 
ATOM   1029 C  CB  . ALA A 1 138 ? 45.911 -12.444 32.756  1.00 51.53 ? 138 ALA A CB  1 
ATOM   1030 N  N   . ALA A 1 139 ? 48.207 -14.563 32.307  1.00 46.95 ? 139 ALA A N   1 
ATOM   1031 C  CA  . ALA A 1 139 ? 49.132 -15.562 32.839  1.00 41.29 ? 139 ALA A CA  1 
ATOM   1032 C  C   . ALA A 1 139 ? 50.559 -15.261 32.424  1.00 44.46 ? 139 ALA A C   1 
ATOM   1033 O  O   . ALA A 1 139 ? 51.495 -15.498 33.193  1.00 45.52 ? 139 ALA A O   1 
ATOM   1034 C  CB  . ALA A 1 139 ? 48.728 -16.955 32.361  1.00 45.56 ? 139 ALA A CB  1 
ATOM   1035 N  N   . LEU A 1 140 ? 50.753 -14.779 31.192  1.00 44.07 ? 140 LEU A N   1 
ATOM   1036 C  CA  . LEU A 1 140 ? 52.099 -14.439 30.743  1.00 43.40 ? 140 LEU A CA  1 
ATOM   1037 C  C   . LEU A 1 140 ? 52.667 -13.331 31.594  1.00 49.47 ? 140 LEU A C   1 
ATOM   1038 O  O   . LEU A 1 140 ? 53.845 -13.361 31.963  1.00 53.29 ? 140 LEU A O   1 
ATOM   1039 C  CB  . LEU A 1 140 ? 52.088 -14.011 29.281  1.00 44.34 ? 140 LEU A CB  1 
ATOM   1040 C  CG  . LEU A 1 140 ? 52.127 -15.093 28.211  1.00 47.03 ? 140 LEU A CG  1 
ATOM   1041 C  CD1 . LEU A 1 140 ? 51.932 -14.434 26.864  1.00 49.06 ? 140 LEU A CD1 1 
ATOM   1042 C  CD2 . LEU A 1 140 ? 53.441 -15.850 28.257  1.00 47.73 ? 140 LEU A CD2 1 
ATOM   1043 N  N   . THR A 1 141 ? 51.842 -12.331 31.910  1.00 46.10 ? 141 THR A N   1 
ATOM   1044 C  CA  . THR A 1 141 ? 52.302 -11.278 32.805  1.00 47.62 ? 141 THR A CA  1 
ATOM   1045 C  C   . THR A 1 141 ? 52.700 -11.848 34.166  1.00 56.23 ? 141 THR A C   1 
ATOM   1046 O  O   . THR A 1 141 ? 53.768 -11.517 34.694  1.00 62.64 ? 141 THR A O   1 
ATOM   1047 C  CB  . THR A 1 141 ? 51.226 -10.207 32.940  1.00 50.22 ? 141 THR A CB  1 
ATOM   1048 O  OG1 . THR A 1 141 ? 51.146 -9.485  31.705  1.00 46.80 ? 141 THR A OG1 1 
ATOM   1049 C  CG2 . THR A 1 141 ? 51.544 -9.255  34.086  1.00 49.77 ? 141 THR A CG2 1 
ATOM   1050 N  N   . ARG A 1 142 ? 51.875 -12.736 34.733  1.00 52.65 ? 142 ARG A N   1 
ATOM   1051 C  CA  . ARG A 1 142 ? 52.225 -13.333 36.030  1.00 56.80 ? 142 ARG A CA  1 
ATOM   1052 C  C   . ARG A 1 142 ? 53.561 -14.087 35.963  1.00 57.99 ? 142 ARG A C   1 
ATOM   1053 O  O   . ARG A 1 142 ? 54.480 -13.844 36.769  1.00 63.85 ? 142 ARG A O   1 
ATOM   1054 C  CB  . ARG A 1 142 ? 51.096 -14.255 36.506  1.00 51.08 ? 142 ARG A CB  1 
ATOM   1055 C  CG  . ARG A 1 142 ? 49.893 -13.498 37.039  1.00 55.23 ? 142 ARG A CG  1 
ATOM   1056 C  CD  . ARG A 1 142 ? 48.915 -14.393 37.780  1.00 65.05 ? 142 ARG A CD  1 
ATOM   1057 N  NE  . ARG A 1 142 ? 48.032 -15.124 36.879  1.00 66.22 ? 142 ARG A NE  1 
ATOM   1058 C  CZ  . ARG A 1 142 ? 46.968 -14.606 36.279  1.00 65.10 ? 142 ARG A CZ  1 
ATOM   1059 N  NH1 . ARG A 1 142 ? 46.615 -13.342 36.466  1.00 66.47 ? 142 ARG A NH1 1 
ATOM   1060 N  NH2 . ARG A 1 142 ? 46.251 -15.370 35.455  1.00 61.01 ? 142 ARG A NH2 1 
ATOM   1061 N  N   . LYS A 1 143 ? 53.704 -14.980 34.975  1.00 57.14 ? 143 LYS A N   1 
ATOM   1062 C  CA  . LYS A 1 143 ? 54.895 -15.824 34.916  1.00 60.21 ? 143 LYS A CA  1 
ATOM   1063 C  C   . LYS A 1 143 ? 56.134 -15.021 34.533  1.00 63.96 ? 143 LYS A C   1 
ATOM   1064 O  O   . LYS A 1 143 ? 57.250 -15.387 34.919  1.00 67.84 ? 143 LYS A O   1 
ATOM   1065 C  CB  . LYS A 1 143 ? 54.702 -16.997 33.939  1.00 57.31 ? 143 LYS A CB  1 
ATOM   1066 C  CG  . LYS A 1 143 ? 56.008 -17.461 33.234  1.00 59.97 ? 143 LYS A CG  1 
ATOM   1067 C  CD  . LYS A 1 143 ? 55.900 -18.813 32.530  1.00 56.44 ? 143 LYS A CD  1 
ATOM   1068 C  CE  . LYS A 1 143 ? 57.289 -19.434 32.277  1.00 58.18 ? 143 LYS A CE  1 
ATOM   1069 N  NZ  . LYS A 1 143 ? 57.764 -19.424 30.861  1.00 54.74 ? 143 LYS A NZ  1 
ATOM   1070 N  N   . TRP A 1 144 ? 55.975 -13.921 33.797  1.00 60.73 ? 144 TRP A N   1 
ATOM   1071 C  CA  . TRP A 1 144 ? 57.151 -13.129 33.468  1.00 64.04 ? 144 TRP A CA  1 
ATOM   1072 C  C   . TRP A 1 144 ? 57.527 -12.186 34.600  1.00 68.81 ? 144 TRP A C   1 
ATOM   1073 O  O   . TRP A 1 144 ? 58.697 -11.804 34.724  1.00 72.15 ? 144 TRP A O   1 
ATOM   1074 C  CB  . TRP A 1 144 ? 56.926 -12.353 32.175  1.00 61.74 ? 144 TRP A CB  1 
ATOM   1075 C  CG  . TRP A 1 144 ? 57.033 -13.214 30.970  1.00 59.72 ? 144 TRP A CG  1 
ATOM   1076 C  CD1 . TRP A 1 144 ? 57.643 -14.440 30.885  1.00 63.51 ? 144 TRP A CD1 1 
ATOM   1077 C  CD2 . TRP A 1 144 ? 56.526 -12.926 29.663  1.00 57.75 ? 144 TRP A CD2 1 
ATOM   1078 N  NE1 . TRP A 1 144 ? 57.538 -14.932 29.605  1.00 61.90 ? 144 TRP A NE1 1 
ATOM   1079 C  CE2 . TRP A 1 144 ? 56.860 -14.022 28.835  1.00 55.56 ? 144 TRP A CE2 1 
ATOM   1080 C  CE3 . TRP A 1 144 ? 55.816 -11.853 29.112  1.00 52.67 ? 144 TRP A CE3 1 
ATOM   1081 C  CZ2 . TRP A 1 144 ? 56.505 -14.072 27.489  1.00 54.72 ? 144 TRP A CZ2 1 
ATOM   1082 C  CZ3 . TRP A 1 144 ? 55.460 -11.909 27.780  1.00 52.65 ? 144 TRP A CZ3 1 
ATOM   1083 C  CH2 . TRP A 1 144 ? 55.809 -13.010 26.980  1.00 54.96 ? 144 TRP A CH2 1 
ATOM   1084 N  N   . ASP A 1 145 ? 56.557 -11.808 35.434  1.00 70.33 ? 145 ASP A N   1 
ATOM   1085 C  CA  . ASP A 1 145 ? 56.882 -11.051 36.634  1.00 72.84 ? 145 ASP A CA  1 
ATOM   1086 C  C   . ASP A 1 145 ? 57.683 -11.902 37.612  1.00 79.34 ? 145 ASP A C   1 
ATOM   1087 O  O   . ASP A 1 145 ? 58.534 -11.373 38.343  1.00 80.48 ? 145 ASP A O   1 
ATOM   1088 C  CB  . ASP A 1 145 ? 55.601 -10.532 37.290  1.00 64.41 ? 145 ASP A CB  1 
ATOM   1089 C  CG  . ASP A 1 145 ? 55.114 -9.229  36.665  1.00 70.37 ? 145 ASP A CG  1 
ATOM   1090 O  OD1 . ASP A 1 145 ? 55.944 -8.521  36.056  1.00 76.15 ? 145 ASP A OD1 1 
ATOM   1091 O  OD2 . ASP A 1 145 ? 53.910 -8.902  36.786  1.00 61.04 ? 145 ASP A OD2 1 
ATOM   1092 N  N   . ASN A 1 146 ? 57.442 -13.223 37.624  1.00 77.96 ? 146 ASN A N   1 
ATOM   1093 C  CA  . ASN A 1 146 ? 58.206 -14.090 38.526  1.00 77.22 ? 146 ASN A CA  1 
ATOM   1094 C  C   . ASN A 1 146 ? 59.633 -14.379 38.061  1.00 78.68 ? 146 ASN A C   1 
ATOM   1095 O  O   . ASN A 1 146 ? 60.460 -14.803 38.877  1.00 84.13 ? 146 ASN A O   1 
ATOM   1096 C  CB  . ASN A 1 146 ? 57.479 -15.417 38.716  1.00 74.93 ? 146 ASN A CB  1 
ATOM   1097 C  CG  . ASN A 1 146 ? 56.498 -15.365 39.852  1.00 77.30 ? 146 ASN A CG  1 
ATOM   1098 O  OD1 . ASN A 1 146 ? 56.603 -16.128 40.819  1.00 76.60 ? 146 ASN A OD1 1 
ATOM   1099 N  ND2 . ASN A 1 146 ? 55.534 -14.449 39.754  1.00 73.15 ? 146 ASN A ND2 1 
ATOM   1100 N  N   . MET A 1 147 ? 59.945 -14.143 36.792  1.00 78.77 ? 147 MET A N   1 
ATOM   1101 C  CA  . MET A 1 147 ? 61.158 -14.731 36.169  1.00 80.00 ? 147 MET A CA  1 
ATOM   1102 C  C   . MET A 1 147 ? 62.463 -14.120 36.647  1.00 81.89 ? 147 MET A C   1 
ATOM   1103 O  O   . MET A 1 147 ? 62.397 -13.124 37.391  1.00 84.71 ? 147 MET A O   1 
ATOM   1104 C  CB  . MET A 1 147 ? 61.081 -14.611 34.645  1.00 79.61 ? 147 MET A CB  1 
ATOM   1105 C  CG  . MET A 1 147 ? 60.516 -15.837 33.966  1.00 74.99 ? 147 MET A CG  1 
ATOM   1106 S  SD  . MET A 1 147 ? 61.088 -15.924 32.257  1.00 89.87 ? 147 MET A SD  1 
ATOM   1107 C  CE  . MET A 1 147 ? 59.900 -17.067 31.562  1.00 68.39 ? 147 MET A CE  1 
ATOM   1108 N  N   . GLU A 1 156 ? 62.673 -19.925 28.674  1.00 67.58 ? 156 GLU A N   1 
ATOM   1109 C  CA  . GLU A 1 156 ? 62.221 -18.574 29.009  1.00 71.56 ? 156 GLU A CA  1 
ATOM   1110 C  C   . GLU A 1 156 ? 62.226 -17.657 27.776  1.00 65.92 ? 156 GLU A C   1 
ATOM   1111 O  O   . GLU A 1 156 ? 61.560 -16.613 27.750  1.00 61.95 ? 156 GLU A O   1 
ATOM   1112 C  CB  . GLU A 1 156 ? 63.096 -17.961 30.118  1.00 67.73 ? 156 GLU A CB  1 
ATOM   1113 C  CG  . GLU A 1 156 ? 64.146 -16.972 29.620  1.00 72.32 ? 156 GLU A CG  1 
ATOM   1114 C  CD  . GLU A 1 156 ? 64.825 -16.198 30.735  1.00 79.80 ? 156 GLU A CD  1 
ATOM   1115 O  OE1 . GLU A 1 156 ? 64.121 -15.510 31.507  1.00 77.53 ? 156 GLU A OE1 1 
ATOM   1116 O  OE2 . GLU A 1 156 ? 66.069 -16.280 30.842  1.00 84.28 ? 156 GLU A OE2 1 
ATOM   1117 N  N   . GLN A 1 157 ? 62.970 -18.063 26.751  1.00 63.86 ? 157 GLN A N   1 
ATOM   1118 C  CA  . GLN A 1 157 ? 63.289 -17.197 25.616  1.00 54.49 ? 157 GLN A CA  1 
ATOM   1119 C  C   . GLN A 1 157 ? 62.258 -17.288 24.491  1.00 53.63 ? 157 GLN A C   1 
ATOM   1120 O  O   . GLN A 1 157 ? 62.613 -17.328 23.299  1.00 45.06 ? 157 GLN A O   1 
ATOM   1121 C  CB  . GLN A 1 157 ? 64.687 -17.558 25.131  1.00 62.59 ? 157 GLN A CB  1 
ATOM   1122 C  CG  . GLN A 1 157 ? 65.439 -16.421 24.515  1.00 61.66 ? 157 GLN A CG  1 
ATOM   1123 C  CD  . GLN A 1 157 ? 66.883 -16.404 24.964  1.00 69.15 ? 157 GLN A CD  1 
ATOM   1124 O  OE1 . GLN A 1 157 ? 67.699 -17.213 24.518  1.00 72.19 ? 157 GLN A OE1 1 
ATOM   1125 N  NE2 . GLN A 1 157 ? 67.204 -15.485 25.876  1.00 69.75 ? 157 GLN A NE2 1 
ATOM   1126 N  N   . TYR A 1 158 ? 60.966 -17.328 24.842  1.00 46.32 ? 158 TYR A N   1 
ATOM   1127 C  CA  . TYR A 1 158 ? 59.892 -17.532 23.880  1.00 45.34 ? 158 TYR A CA  1 
ATOM   1128 C  C   . TYR A 1 158 ? 58.808 -16.484 24.070  1.00 45.65 ? 158 TYR A C   1 
ATOM   1129 O  O   . TYR A 1 158 ? 58.466 -16.124 25.202  1.00 41.46 ? 158 TYR A O   1 
ATOM   1130 C  CB  . TYR A 1 158 ? 59.276 -18.929 24.014  1.00 41.72 ? 158 TYR A CB  1 
ATOM   1131 C  CG  . TYR A 1 158 ? 60.248 -20.017 23.586  1.00 49.54 ? 158 TYR A CG  1 
ATOM   1132 C  CD1 . TYR A 1 158 ? 60.543 -20.231 22.242  1.00 49.22 ? 158 TYR A CD1 1 
ATOM   1133 C  CD2 . TYR A 1 158 ? 60.927 -20.773 24.536  1.00 51.66 ? 158 TYR A CD2 1 
ATOM   1134 C  CE1 . TYR A 1 158 ? 61.446 -21.208 21.854  1.00 52.96 ? 158 TYR A CE1 1 
ATOM   1135 C  CE2 . TYR A 1 158 ? 61.833 -21.752 24.161  1.00 52.59 ? 158 TYR A CE2 1 
ATOM   1136 C  CZ  . TYR A 1 158 ? 62.092 -21.959 22.821  1.00 54.76 ? 158 TYR A CZ  1 
ATOM   1137 O  OH  . TYR A 1 158 ? 62.997 -22.920 22.423  1.00 64.02 ? 158 TYR A OH  1 
ATOM   1138 N  N   . GLY A 1 159 ? 58.254 -16.017 22.951  1.00 44.94 ? 159 GLY A N   1 
ATOM   1139 C  CA  . GLY A 1 159 ? 57.146 -15.092 22.956  1.00 41.42 ? 159 GLY A CA  1 
ATOM   1140 C  C   . GLY A 1 159 ? 55.954 -15.661 22.209  1.00 42.19 ? 159 GLY A C   1 
ATOM   1141 O  O   . GLY A 1 159 ? 55.982 -16.790 21.710  1.00 37.68 ? 159 GLY A O   1 
ATOM   1142 N  N   . ILE A 1 160 ? 54.902 -14.847 22.128  1.00 39.11 ? 160 ILE A N   1 
ATOM   1143 C  CA  . ILE A 1 160 ? 53.654 -15.248 21.483  1.00 35.43 ? 160 ILE A CA  1 
ATOM   1144 C  C   . ILE A 1 160 ? 53.346 -14.260 20.365  1.00 37.26 ? 160 ILE A C   1 
ATOM   1145 O  O   . ILE A 1 160 ? 53.582 -13.052 20.501  1.00 37.21 ? 160 ILE A O   1 
ATOM   1146 C  CB  . ILE A 1 160 ? 52.488 -15.329 22.498  1.00 36.40 ? 160 ILE A CB  1 
ATOM   1147 C  CG1 . ILE A 1 160 ? 51.170 -15.687 21.817  1.00 35.17 ? 160 ILE A CG1 1 
ATOM   1148 C  CG2 . ILE A 1 160 ? 52.318 -14.002 23.224  1.00 40.70 ? 160 ILE A CG2 1 
ATOM   1149 C  CD1 . ILE A 1 160 ? 51.112 -17.075 21.265  1.00 38.04 ? 160 ILE A CD1 1 
ATOM   1150 N  N   . GLN A 1 161 ? 52.854 -14.781 19.247  1.00 36.89 ? 161 GLN A N   1 
ATOM   1151 C  CA  . GLN A 1 161 ? 52.644 -13.978 18.054  1.00 35.36 ? 161 GLN A CA  1 
ATOM   1152 C  C   . GLN A 1 161 ? 51.385 -14.431 17.351  1.00 37.32 ? 161 GLN A C   1 
ATOM   1153 O  O   . GLN A 1 161 ? 51.072 -15.623 17.324  1.00 36.31 ? 161 GLN A O   1 
ATOM   1154 C  CB  . GLN A 1 161 ? 53.858 -14.099 17.120  1.00 40.74 ? 161 GLN A CB  1 
ATOM   1155 C  CG  . GLN A 1 161 ? 53.823 -13.210 15.924  1.00 41.29 ? 161 GLN A CG  1 
ATOM   1156 C  CD  . GLN A 1 161 ? 55.165 -13.147 15.243  1.00 41.91 ? 161 GLN A CD  1 
ATOM   1157 O  OE1 . GLN A 1 161 ? 55.648 -12.061 14.922  1.00 43.39 ? 161 GLN A OE1 1 
ATOM   1158 N  NE2 . GLN A 1 161 ? 55.788 -14.313 15.022  1.00 40.35 ? 161 GLN A NE2 1 
ATOM   1159 N  N   . VAL A 1 162 ? 50.628 -13.473 16.819  1.00 35.65 ? 162 VAL A N   1 
ATOM   1160 C  CA  . VAL A 1 162 ? 49.477 -13.788 16.003  1.00 32.61 ? 162 VAL A CA  1 
ATOM   1161 C  C   . VAL A 1 162 ? 49.664 -13.090 14.663  1.00 34.72 ? 162 VAL A C   1 
ATOM   1162 O  O   . VAL A 1 162 ? 50.296 -12.031 14.566  1.00 34.79 ? 162 VAL A O   1 
ATOM   1163 C  CB  . VAL A 1 162 ? 48.146 -13.354 16.663  1.00 36.24 ? 162 VAL A CB  1 
ATOM   1164 C  CG1 . VAL A 1 162 ? 48.050 -13.922 18.071  1.00 32.13 ? 162 VAL A CG1 1 
ATOM   1165 C  CG2 . VAL A 1 162 ? 48.093 -11.857 16.691  1.00 31.18 ? 162 VAL A CG2 1 
ATOM   1166 N  N   . ILE A 1 163 ? 49.147 -13.729 13.626  1.00 30.27 ? 163 ILE A N   1 
ATOM   1167 C  CA  . ILE A 1 163 ? 49.179 -13.221 12.262  1.00 30.03 ? 163 ILE A CA  1 
ATOM   1168 C  C   . ILE A 1 163 ? 47.805 -13.455 11.683  1.00 33.80 ? 163 ILE A C   1 
ATOM   1169 O  O   . ILE A 1 163 ? 47.376 -14.609 11.545  1.00 30.45 ? 163 ILE A O   1 
ATOM   1170 C  CB  . ILE A 1 163 ? 50.214 -13.927 11.366  1.00 32.29 ? 163 ILE A CB  1 
ATOM   1171 C  CG1 . ILE A 1 163 ? 51.628 -13.743 11.882  1.00 31.83 ? 163 ILE A CG1 1 
ATOM   1172 C  CG2 . ILE A 1 163 ? 50.096 -13.392 9.943   1.00 31.71 ? 163 ILE A CG2 1 
ATOM   1173 C  CD1 . ILE A 1 163 ? 52.675 -14.583 11.099  1.00 36.90 ? 163 ILE A CD1 1 
ATOM   1174 N  N   . PHE A 1 164 ? 47.122 -12.374 11.312  1.00 35.13 ? 164 PHE A N   1 
ATOM   1175 C  CA  . PHE A 1 164 ? 45.906 -12.457 10.530  1.00 33.01 ? 164 PHE A CA  1 
ATOM   1176 C  C   . PHE A 1 164 ? 46.283 -12.125 9.093   1.00 32.19 ? 164 PHE A C   1 
ATOM   1177 O  O   . PHE A 1 164 ? 46.690 -10.992 8.783   1.00 31.28 ? 164 PHE A O   1 
ATOM   1178 C  CB  . PHE A 1 164 ? 44.839 -11.514 11.087  1.00 33.35 ? 164 PHE A CB  1 
ATOM   1179 C  CG  . PHE A 1 164 ? 44.565 -11.747 12.543  1.00 31.44 ? 164 PHE A CG  1 
ATOM   1180 C  CD1 . PHE A 1 164 ? 43.673 -12.723 12.934  1.00 32.92 ? 164 PHE A CD1 1 
ATOM   1181 C  CD2 . PHE A 1 164 ? 45.240 -11.039 13.507  1.00 34.67 ? 164 PHE A CD2 1 
ATOM   1182 C  CE1 . PHE A 1 164 ? 43.422 -12.943 14.294  1.00 32.95 ? 164 PHE A CE1 1 
ATOM   1183 C  CE2 . PHE A 1 164 ? 45.000 -11.275 14.877  1.00 34.35 ? 164 PHE A CE2 1 
ATOM   1184 C  CZ  . PHE A 1 164 ? 44.091 -12.225 15.241  1.00 32.05 ? 164 PHE A CZ  1 
ATOM   1185 N  N   . THR A 1 165 ? 46.166 -13.121 8.233   1.00 33.31 ? 165 THR A N   1 
ATOM   1186 C  CA  . THR A 1 165 ? 46.666 -13.026 6.878   1.00 33.54 ? 165 THR A CA  1 
ATOM   1187 C  C   . THR A 1 165 ? 45.577 -12.490 5.976   1.00 31.60 ? 165 THR A C   1 
ATOM   1188 O  O   . THR A 1 165 ? 44.407 -12.850 6.119   1.00 35.84 ? 165 THR A O   1 
ATOM   1189 C  CB  . THR A 1 165 ? 47.083 -14.396 6.347   1.00 31.44 ? 165 THR A CB  1 
ATOM   1190 O  OG1 . THR A 1 165 ? 45.999 -15.325 6.504   1.00 32.36 ? 165 THR A OG1 1 
ATOM   1191 C  CG2 . THR A 1 165 ? 48.306 -14.904 7.094   1.00 33.69 ? 165 THR A CG2 1 
ATOM   1192 N  N   . ASP A 1 166 ? 45.979 -11.675 5.017   1.00 35.70 ? 166 ASP A N   1 
ATOM   1193 C  CA  . ASP A 1 166 ? 45.075 -11.155 4.004   1.00 37.47 ? 166 ASP A CA  1 
ATOM   1194 C  C   . ASP A 1 166 ? 45.249 -11.973 2.738   1.00 43.45 ? 166 ASP A C   1 
ATOM   1195 O  O   . ASP A 1 166 ? 46.269 -12.642 2.547   1.00 40.15 ? 166 ASP A O   1 
ATOM   1196 C  CB  . ASP A 1 166 ? 45.379 -9.680  3.738   1.00 38.72 ? 166 ASP A CB  1 
ATOM   1197 C  CG  . ASP A 1 166 ? 44.212 -8.929  3.142   1.00 36.05 ? 166 ASP A CG  1 
ATOM   1198 O  OD1 . ASP A 1 166 ? 43.147 -9.531  2.825   1.00 37.39 ? 166 ASP A OD1 1 
ATOM   1199 O  OD2 . ASP A 1 166 ? 44.397 -7.716  2.988   1.00 40.17 ? 166 ASP A OD2 1 
ATOM   1200 N  N   . GLY A 1 167 ? 44.209 -11.976 1.908   1.00 34.80 ? 167 GLY A N   1 
ATOM   1201 C  CA  . GLY A 1 167 ? 44.324 -12.510 0.570   1.00 33.47 ? 167 GLY A CA  1 
ATOM   1202 C  C   . GLY A 1 167 ? 44.585 -13.994 0.510   1.00 39.34 ? 167 GLY A C   1 
ATOM   1203 O  O   . GLY A 1 167 ? 45.199 -14.467 -0.447  1.00 36.57 ? 167 GLY A O   1 
ATOM   1204 N  N   . GLU A 1 168 ? 44.149 -14.746 1.515   1.00 34.30 ? 168 GLU A N   1 
ATOM   1205 C  CA  . GLU A 1 168 ? 44.217 -16.194 1.401   1.00 34.18 ? 168 GLU A CA  1 
ATOM   1206 C  C   . GLU A 1 168 ? 43.455 -16.666 0.183   1.00 39.14 ? 168 GLU A C   1 
ATOM   1207 O  O   . GLU A 1 168 ? 43.964 -17.464 -0.603  1.00 34.02 ? 168 GLU A O   1 
ATOM   1208 C  CB  . GLU A 1 168 ? 43.653 -16.861 2.654   1.00 33.90 ? 168 GLU A CB  1 
ATOM   1209 C  CG  . GLU A 1 168 ? 43.958 -18.359 2.715   1.00 37.91 ? 168 GLU A CG  1 
ATOM   1210 C  CD  . GLU A 1 168 ? 43.079 -19.183 1.821   1.00 39.56 ? 168 GLU A CD  1 
ATOM   1211 O  OE1 . GLU A 1 168 ? 41.895 -18.833 1.659   1.00 41.26 ? 168 GLU A OE1 1 
ATOM   1212 O  OE2 . GLU A 1 168 ? 43.581 -20.186 1.251   1.00 40.47 ? 168 GLU A OE2 1 
ATOM   1213 N  N   . GLU A 1 169 ? 42.211 -16.192 0.020   1.00 31.83 ? 169 GLU A N   1 
ATOM   1214 C  CA  . GLU A 1 169 ? 41.301 -16.781 -0.946  1.00 37.11 ? 169 GLU A CA  1 
ATOM   1215 C  C   . GLU A 1 169 ? 41.729 -16.438 -2.366  1.00 33.40 ? 169 GLU A C   1 
ATOM   1216 O  O   . GLU A 1 169 ? 42.231 -15.342 -2.640  1.00 34.07 ? 169 GLU A O   1 
ATOM   1217 C  CB  . GLU A 1 169 ? 39.865 -16.293 -0.674  1.00 38.50 ? 169 GLU A CB  1 
ATOM   1218 C  CG  . GLU A 1 169 ? 39.292 -16.650 0.735   1.00 35.95 ? 169 GLU A CG  1 
ATOM   1219 C  CD  . GLU A 1 169 ? 38.730 -18.050 0.779   1.00 32.04 ? 169 GLU A CD  1 
ATOM   1220 O  OE1 . GLU A 1 169 ? 38.949 -18.716 -0.239  1.00 37.41 ? 169 GLU A OE1 1 
ATOM   1221 O  OE2 . GLU A 1 169 ? 38.145 -18.520 1.808   1.00 29.84 ? 169 GLU A OE2 1 
ATOM   1222 N  N   . SER A 1 170 ? 41.576 -17.403 -3.263  1.00 32.53 ? 170 SER A N   1 
ATOM   1223 C  CA  . SER A 1 170 ? 41.885 -17.184 -4.667  1.00 35.13 ? 170 SER A CA  1 
ATOM   1224 C  C   . SER A 1 170 ? 40.740 -16.399 -5.307  1.00 43.15 ? 170 SER A C   1 
ATOM   1225 O  O   . SER A 1 170 ? 39.613 -16.395 -4.803  1.00 35.08 ? 170 SER A O   1 
ATOM   1226 C  CB  . SER A 1 170 ? 42.070 -18.517 -5.400  1.00 40.86 ? 170 SER A CB  1 
ATOM   1227 O  OG  . SER A 1 170 ? 43.094 -19.319 -4.809  1.00 39.45 ? 170 SER A OG  1 
ATOM   1228 N  N   . PHE A 1 171 ? 41.030 -15.756 -6.437  1.00 41.94 ? 171 PHE A N   1 
ATOM   1229 C  CA  . PHE A 1 171 ? 40.037 -14.951 -7.152  1.00 47.00 ? 171 PHE A CA  1 
ATOM   1230 C  C   . PHE A 1 171 ? 39.550 -15.561 -8.458  1.00 47.13 ? 171 PHE A C   1 
ATOM   1231 O  O   . PHE A 1 171 ? 38.421 -15.281 -8.871  1.00 51.95 ? 171 PHE A O   1 
ATOM   1232 C  CB  . PHE A 1 171 ? 40.608 -13.568 -7.463  1.00 42.17 ? 171 PHE A CB  1 
ATOM   1233 C  CG  . PHE A 1 171 ? 40.779 -12.706 -6.262  1.00 44.03 ? 171 PHE A CG  1 
ATOM   1234 C  CD1 . PHE A 1 171 ? 39.684 -12.089 -5.684  1.00 44.79 ? 171 PHE A CD1 1 
ATOM   1235 C  CD2 . PHE A 1 171 ? 42.031 -12.521 -5.699  1.00 44.80 ? 171 PHE A CD2 1 
ATOM   1236 C  CE1 . PHE A 1 171 ? 39.825 -11.285 -4.580  1.00 40.61 ? 171 PHE A CE1 1 
ATOM   1237 C  CE2 . PHE A 1 171 ? 42.188 -11.723 -4.581  1.00 44.64 ? 171 PHE A CE2 1 
ATOM   1238 C  CZ  . PHE A 1 171 ? 41.079 -11.114 -4.011  1.00 40.76 ? 171 PHE A CZ  1 
ATOM   1239 N  N   . GLY A 1 172 ? 40.363 -16.373 -9.123  1.00 46.26 ? 172 GLY A N   1 
ATOM   1240 C  CA  . GLY A 1 172 ? 40.036 -16.813 -10.462 1.00 54.14 ? 172 GLY A CA  1 
ATOM   1241 C  C   . GLY A 1 172 ? 39.092 -17.992 -10.495 1.00 58.35 ? 172 GLY A C   1 
ATOM   1242 O  O   . GLY A 1 172 ? 38.898 -18.692 -9.508  1.00 52.73 ? 172 GLY A O   1 
ATOM   1243 N  N   . ASN A 1 173 ? 38.479 -18.190 -11.669 1.00 61.45 ? 173 ASN A N   1 
ATOM   1244 C  CA  . ASN A 1 173 ? 37.589 -19.330 -11.869 1.00 65.03 ? 173 ASN A CA  1 
ATOM   1245 C  C   . ASN A 1 173 ? 38.357 -20.635 -11.898 1.00 67.98 ? 173 ASN A C   1 
ATOM   1246 O  O   . ASN A 1 173 ? 37.829 -21.681 -11.504 1.00 71.82 ? 173 ASN A O   1 
ATOM   1247 C  CB  . ASN A 1 173 ? 36.828 -19.199 -13.186 1.00 66.92 ? 173 ASN A CB  1 
ATOM   1248 C  CG  . ASN A 1 173 ? 36.216 -17.846 -13.369 1.00 71.96 ? 173 ASN A CG  1 
ATOM   1249 O  OD1 . ASN A 1 173 ? 36.191 -17.034 -12.441 1.00 69.71 ? 173 ASN A OD1 1 
ATOM   1250 N  ND2 . ASN A 1 173 ? 35.716 -17.582 -14.575 1.00 75.83 ? 173 ASN A ND2 1 
ATOM   1251 N  N   . THR A 1 174 ? 39.590 -20.592 -12.379 1.00 67.26 ? 174 THR A N   1 
ATOM   1252 C  CA  . THR A 1 174 ? 40.352 -21.786 -12.685 1.00 70.90 ? 174 THR A CA  1 
ATOM   1253 C  C   . THR A 1 174 ? 41.609 -21.842 -11.821 1.00 67.02 ? 174 THR A C   1 
ATOM   1254 O  O   . THR A 1 174 ? 42.124 -20.809 -11.376 1.00 61.76 ? 174 THR A O   1 
ATOM   1255 C  CB  . THR A 1 174 ? 40.693 -21.804 -14.179 1.00 71.99 ? 174 THR A CB  1 
ATOM   1256 O  OG1 . THR A 1 174 ? 41.226 -20.527 -14.558 1.00 74.24 ? 174 THR A OG1 1 
ATOM   1257 C  CG2 . THR A 1 174 ? 39.422 -22.084 -15.005 1.00 72.40 ? 174 THR A CG2 1 
ATOM   1258 N  N   . LEU A 1 175 ? 42.091 -23.068 -11.585 1.00 66.75 ? 175 LEU A N   1 
ATOM   1259 C  CA  . LEU A 1 175 ? 43.228 -23.301 -10.698 1.00 59.09 ? 175 LEU A CA  1 
ATOM   1260 C  C   . LEU A 1 175 ? 44.496 -22.694 -11.285 1.00 62.86 ? 175 LEU A C   1 
ATOM   1261 O  O   . LEU A 1 175 ? 44.889 -23.025 -12.407 1.00 65.32 ? 175 LEU A O   1 
ATOM   1262 C  CB  . LEU A 1 175 ? 43.411 -24.792 -10.473 1.00 58.81 ? 175 LEU A CB  1 
ATOM   1263 C  CG  . LEU A 1 175 ? 44.310 -25.197 -9.310  1.00 64.91 ? 175 LEU A CG  1 
ATOM   1264 C  CD1 . LEU A 1 175 ? 44.253 -24.187 -8.153  1.00 59.29 ? 175 LEU A CD1 1 
ATOM   1265 C  CD2 . LEU A 1 175 ? 43.887 -26.583 -8.837  1.00 63.37 ? 175 LEU A CD2 1 
ATOM   1266 N  N   . THR A 1 176 ? 45.144 -21.822 -10.513 1.00 61.37 ? 176 THR A N   1 
ATOM   1267 C  CA  . THR A 1 176 ? 46.252 -21.006 -10.995 1.00 56.93 ? 176 THR A CA  1 
ATOM   1268 C  C   . THR A 1 176 ? 47.291 -20.868 -9.893  1.00 54.94 ? 176 THR A C   1 
ATOM   1269 O  O   . THR A 1 176 ? 46.967 -20.433 -8.782  1.00 53.23 ? 176 THR A O   1 
ATOM   1270 C  CB  . THR A 1 176 ? 45.740 -19.632 -11.438 1.00 57.97 ? 176 THR A CB  1 
ATOM   1271 O  OG1 . THR A 1 176 ? 45.212 -19.744 -12.761 1.00 69.84 ? 176 THR A OG1 1 
ATOM   1272 C  CG2 . THR A 1 176 ? 46.830 -18.590 -11.422 1.00 54.51 ? 176 THR A CG2 1 
ATOM   1273 N  N   . ALA A 1 177 ? 48.543 -21.204 -10.222 1.00 51.47 ? 177 ALA A N   1 
ATOM   1274 C  CA  . ALA A 1 177 ? 49.558 -21.432 -9.194  1.00 49.57 ? 177 ALA A CA  1 
ATOM   1275 C  C   . ALA A 1 177 ? 49.804 -20.203 -8.326  1.00 44.23 ? 177 ALA A C   1 
ATOM   1276 O  O   . ALA A 1 177 ? 50.020 -20.336 -7.117  1.00 48.68 ? 177 ALA A O   1 
ATOM   1277 C  CB  . ALA A 1 177 ? 50.863 -21.882 -9.845  1.00 40.23 ? 177 ALA A CB  1 
ATOM   1278 N  N   . ASN A 1 178 ? 49.840 -19.009 -8.927  1.00 42.97 ? 178 ASN A N   1 
ATOM   1279 C  CA  . ASN A 1 178 ? 50.122 -17.773 -8.202  1.00 45.00 ? 178 ASN A CA  1 
ATOM   1280 C  C   . ASN A 1 178 ? 48.854 -17.014 -7.787  1.00 40.07 ? 178 ASN A C   1 
ATOM   1281 O  O   . ASN A 1 178 ? 48.934 -15.832 -7.426  1.00 42.83 ? 178 ASN A O   1 
ATOM   1282 C  CB  . ASN A 1 178 ? 51.037 -16.863 -9.036  1.00 48.47 ? 178 ASN A CB  1 
ATOM   1283 C  CG  . ASN A 1 178 ? 50.354 -16.299 -10.276 1.00 51.73 ? 178 ASN A CG  1 
ATOM   1284 O  OD1 . ASN A 1 178 ? 49.333 -16.817 -10.745 1.00 54.86 ? 178 ASN A OD1 1 
ATOM   1285 N  ND2 . ASN A 1 178 ? 50.914 -15.217 -10.807 1.00 53.03 ? 178 ASN A ND2 1 
ATOM   1286 N  N   . ASP A 1 179 ? 47.699 -17.660 -7.856  1.00 41.43 ? 179 ASP A N   1 
ATOM   1287 C  CA  . ASP A 1 179 ? 46.441 -17.106 -7.361  1.00 45.21 ? 179 ASP A CA  1 
ATOM   1288 C  C   . ASP A 1 179 ? 46.257 -17.618 -5.943  1.00 40.17 ? 179 ASP A C   1 
ATOM   1289 O  O   . ASP A 1 179 ? 46.526 -18.789 -5.664  1.00 46.48 ? 179 ASP A O   1 
ATOM   1290 C  CB  . ASP A 1 179 ? 45.282 -17.551 -8.267  1.00 46.17 ? 179 ASP A CB  1 
ATOM   1291 C  CG  . ASP A 1 179 ? 43.960 -16.848 -7.963  1.00 43.98 ? 179 ASP A CG  1 
ATOM   1292 O  OD1 . ASP A 1 179 ? 43.983 -15.709 -7.443  1.00 42.42 ? 179 ASP A OD1 1 
ATOM   1293 O  OD2 . ASP A 1 179 ? 42.907 -17.469 -8.255  1.00 42.56 ? 179 ASP A OD2 1 
ATOM   1294 N  N   . GLY A 1 180 ? 45.863 -16.737 -5.037  1.00 41.51 ? 180 GLY A N   1 
ATOM   1295 C  CA  . GLY A 1 180 ? 45.675 -17.140 -3.657  1.00 36.96 ? 180 GLY A CA  1 
ATOM   1296 C  C   . GLY A 1 180 ? 46.938 -17.015 -2.817  1.00 35.88 ? 180 GLY A C   1 
ATOM   1297 O  O   . GLY A 1 180 ? 48.058 -16.859 -3.318  1.00 36.31 ? 180 GLY A O   1 
ATOM   1298 N  N   . LEU A 1 181 ? 46.734 -17.052 -1.498  1.00 33.58 ? 181 LEU A N   1 
ATOM   1299 C  CA  . LEU A 1 181 ? 47.832 -16.987 -0.536  1.00 33.49 ? 181 LEU A CA  1 
ATOM   1300 C  C   . LEU A 1 181 ? 48.668 -15.736 -0.752  1.00 33.53 ? 181 LEU A C   1 
ATOM   1301 O  O   . LEU A 1 181 ? 49.886 -15.742 -0.573  1.00 33.87 ? 181 LEU A O   1 
ATOM   1302 C  CB  . LEU A 1 181 ? 48.690 -18.273 -0.589  1.00 35.50 ? 181 LEU A CB  1 
ATOM   1303 C  CG  . LEU A 1 181 ? 47.945 -19.630 -0.671  1.00 33.75 ? 181 LEU A CG  1 
ATOM   1304 C  CD1 . LEU A 1 181 ? 48.920 -20.871 -0.633  1.00 31.96 ? 181 LEU A CD1 1 
ATOM   1305 C  CD2 . LEU A 1 181 ? 46.895 -19.825 0.411   1.00 34.70 ? 181 LEU A CD2 1 
ATOM   1306 N  N   . TYR A 1 182 ? 48.008 -14.617 -1.118  1.00 37.25 ? 182 TYR A N   1 
ATOM   1307 C  CA  . TYR A 1 182 ? 48.775 -13.411 -1.430  1.00 37.55 ? 182 TYR A CA  1 
ATOM   1308 C  C   . TYR A 1 182 ? 49.491 -12.881 -0.194  1.00 33.50 ? 182 TYR A C   1 
ATOM   1309 O  O   . TYR A 1 182 ? 50.700 -12.571 -0.242  1.00 34.45 ? 182 TYR A O   1 
ATOM   1310 C  CB  . TYR A 1 182 ? 47.874 -12.331 -2.052  1.00 37.42 ? 182 TYR A CB  1 
ATOM   1311 C  CG  . TYR A 1 182 ? 47.278 -12.679 -3.420  1.00 38.89 ? 182 TYR A CG  1 
ATOM   1312 C  CD1 . TYR A 1 182 ? 46.097 -13.396 -3.530  1.00 41.61 ? 182 TYR A CD1 1 
ATOM   1313 C  CD2 . TYR A 1 182 ? 47.894 -12.273 -4.598  1.00 40.57 ? 182 TYR A CD2 1 
ATOM   1314 C  CE1 . TYR A 1 182 ? 45.545 -13.695 -4.771  1.00 39.91 ? 182 TYR A CE1 1 
ATOM   1315 C  CE2 . TYR A 1 182 ? 47.352 -12.581 -5.836  1.00 39.81 ? 182 TYR A CE2 1 
ATOM   1316 C  CZ  . TYR A 1 182 ? 46.186 -13.282 -5.917  1.00 41.62 ? 182 TYR A CZ  1 
ATOM   1317 O  OH  . TYR A 1 182 ? 45.648 -13.584 -7.138  1.00 45.35 ? 182 TYR A OH  1 
ATOM   1318 N  N   . GLY A 1 183 ? 48.786 -12.831 0.944   1.00 33.01 ? 183 GLY A N   1 
ATOM   1319 C  CA  . GLY A 1 183 ? 49.405 -12.302 2.143   1.00 34.90 ? 183 GLY A CA  1 
ATOM   1320 C  C   . GLY A 1 183 ? 50.465 -13.234 2.699   1.00 35.87 ? 183 GLY A C   1 
ATOM   1321 O  O   . GLY A 1 183 ? 51.553 -12.793 3.075   1.00 35.05 ? 183 GLY A O   1 
ATOM   1322 N  N   . SER A 1 184 ? 50.166 -14.528 2.762   1.00 31.64 ? 184 SER A N   1 
ATOM   1323 C  CA  . SER A 1 184 ? 51.132 -15.452 3.360   1.00 35.26 ? 184 SER A CA  1 
ATOM   1324 C  C   . SER A 1 184 ? 52.394 -15.559 2.511   1.00 37.00 ? 184 SER A C   1 
ATOM   1325 O  O   . SER A 1 184 ? 53.504 -15.554 3.052   1.00 34.73 ? 184 SER A O   1 
ATOM   1326 C  CB  . SER A 1 184 ? 50.513 -16.831 3.574   1.00 33.78 ? 184 SER A CB  1 
ATOM   1327 O  OG  . SER A 1 184 ? 49.842 -17.294 2.415   1.00 37.06 ? 184 SER A OG  1 
ATOM   1328 N  N   . ARG A 1 185 ? 52.257 -15.641 1.183   1.00 37.18 ? 185 ARG A N   1 
ATOM   1329 C  CA  . ARG A 1 185 ? 53.479 -15.649 0.332   1.00 34.22 ? 185 ARG A CA  1 
ATOM   1330 C  C   . ARG A 1 185 ? 54.326 -14.382 0.567   1.00 34.74 ? 185 ARG A C   1 
ATOM   1331 O  O   . ARG A 1 185 ? 55.523 -14.518 0.783   1.00 41.21 ? 185 ARG A O   1 
ATOM   1332 C  CB  . ARG A 1 185 ? 53.083 -15.877 -1.126  1.00 32.18 ? 185 ARG A CB  1 
ATOM   1333 C  CG  . ARG A 1 185 ? 52.431 -17.227 -1.381  1.00 33.05 ? 185 ARG A CG  1 
ATOM   1334 C  CD  . ARG A 1 185 ? 52.037 -17.435 -2.826  1.00 35.42 ? 185 ARG A CD  1 
ATOM   1335 N  NE  . ARG A 1 185 ? 51.885 -18.854 -3.087  1.00 38.96 ? 185 ARG A NE  1 
ATOM   1336 C  CZ  . ARG A 1 185 ? 51.023 -19.373 -3.947  1.00 43.05 ? 185 ARG A CZ  1 
ATOM   1337 N  NH1 . ARG A 1 185 ? 50.227 -18.583 -4.644  1.00 45.56 ? 185 ARG A NH1 1 
ATOM   1338 N  NH2 . ARG A 1 185 ? 50.962 -20.681 -4.107  1.00 39.81 ? 185 ARG A NH2 1 
ATOM   1339 N  N   . SER A 1 186 ? 53.715 -13.201 0.561   1.00 38.31 ? 186 SER A N   1 
ATOM   1340 C  CA  . SER A 1 186 ? 54.474 -11.943 0.778   1.00 38.43 ? 186 SER A CA  1 
ATOM   1341 C  C   . SER A 1 186 ? 55.155 -11.951 2.147   1.00 39.06 ? 186 SER A C   1 
ATOM   1342 O  O   . SER A 1 186 ? 56.337 -11.619 2.206   1.00 41.08 ? 186 SER A O   1 
ATOM   1343 C  CB  . SER A 1 186 ? 53.614 -10.720 0.617   1.00 40.16 ? 186 SER A CB  1 
ATOM   1344 O  OG  . SER A 1 186 ? 54.366 -9.540  0.837   1.00 43.50 ? 186 SER A OG  1 
ATOM   1345 N  N   . LEU A 1 187 ? 54.430 -12.311 3.201   1.00 34.70 ? 187 LEU A N   1 
ATOM   1346 C  CA  . LEU A 1 187 ? 55.008 -12.236 4.568   1.00 37.43 ? 187 LEU A CA  1 
ATOM   1347 C  C   . LEU A 1 187 ? 56.199 -13.186 4.687   1.00 35.61 ? 187 LEU A C   1 
ATOM   1348 O  O   . LEU A 1 187 ? 57.250 -12.762 5.155   1.00 39.33 ? 187 LEU A O   1 
ATOM   1349 C  CB  . LEU A 1 187 ? 53.939 -12.587 5.605   1.00 36.07 ? 187 LEU A CB  1 
ATOM   1350 C  CG  . LEU A 1 187 ? 54.312 -12.256 7.047   1.00 40.46 ? 187 LEU A CG  1 
ATOM   1351 C  CD1 . LEU A 1 187 ? 54.793 -10.821 7.154   1.00 43.56 ? 187 LEU A CD1 1 
ATOM   1352 C  CD2 . LEU A 1 187 ? 53.140 -12.494 7.982   1.00 41.17 ? 187 LEU A CD2 1 
ATOM   1353 N  N   . ALA A 1 188 ? 55.999 -14.436 4.299   1.00 36.67 ? 188 ALA A N   1 
ATOM   1354 C  CA  . ALA A 1 188 ? 57.084 -15.427 4.408   1.00 39.69 ? 188 ALA A CA  1 
ATOM   1355 C  C   . ALA A 1 188 ? 58.264 -14.916 3.596   1.00 36.40 ? 188 ALA A C   1 
ATOM   1356 O  O   . ALA A 1 188 ? 59.376 -14.876 4.120   1.00 40.59 ? 188 ALA A O   1 
ATOM   1357 C  CB  . ALA A 1 188 ? 56.589 -16.742 3.896   1.00 36.41 ? 188 ALA A CB  1 
ATOM   1358 N  N   . ALA A 1 189 ? 57.986 -14.501 2.373   1.00 35.61 ? 189 ALA A N   1 
ATOM   1359 C  CA  . ALA A 1 189 ? 59.044 -14.021 1.464   1.00 46.28 ? 189 ALA A CA  1 
ATOM   1360 C  C   . ALA A 1 189 ? 59.810 -12.851 2.121   1.00 44.81 ? 189 ALA A C   1 
ATOM   1361 O  O   . ALA A 1 189 ? 61.040 -12.877 2.098   1.00 44.80 ? 189 ALA A O   1 
ATOM   1362 C  CB  . ALA A 1 189 ? 58.378 -13.733 0.122   1.00 41.25 ? 189 ALA A CB  1 
ATOM   1363 N  N   . HIS A 1 190 ? 59.115 -11.913 2.767   1.00 41.61 ? 190 HIS A N   1 
ATOM   1364 C  CA  . HIS A 1 190 ? 59.774 -10.722 3.375   1.00 42.96 ? 190 HIS A CA  1 
ATOM   1365 C  C   . HIS A 1 190 ? 60.505 -11.079 4.671   1.00 44.38 ? 190 HIS A C   1 
ATOM   1366 O  O   . HIS A 1 190 ? 61.604 -10.580 4.887   1.00 47.54 ? 190 HIS A O   1 
ATOM   1367 C  CB  . HIS A 1 190 ? 58.744 -9.633  3.667   1.00 45.66 ? 190 HIS A CB  1 
ATOM   1368 C  CG  . HIS A 1 190 ? 58.439 -8.753  2.503   1.00 55.48 ? 190 HIS A CG  1 
ATOM   1369 N  ND1 . HIS A 1 190 ? 58.434 -9.220  1.205   1.00 59.55 ? 190 HIS A ND1 1 
ATOM   1370 C  CD2 . HIS A 1 190 ? 58.122 -7.442  2.436   1.00 58.89 ? 190 HIS A CD2 1 
ATOM   1371 C  CE1 . HIS A 1 190 ? 58.128 -8.234  0.388   1.00 60.01 ? 190 HIS A CE1 1 
ATOM   1372 N  NE2 . HIS A 1 190 ? 57.931 -7.133  1.118   1.00 61.05 ? 190 HIS A NE2 1 
ATOM   1373 N  N   . TRP A 1 191 ? 59.876 -11.887 5.513   1.00 40.31 ? 191 TRP A N   1 
ATOM   1374 C  CA  . TRP A 1 191 ? 60.489 -12.288 6.797   1.00 37.70 ? 191 TRP A CA  1 
ATOM   1375 C  C   . TRP A 1 191 ? 61.670 -13.218 6.532   1.00 42.89 ? 191 TRP A C   1 
ATOM   1376 O  O   . TRP A 1 191 ? 62.547 -13.282 7.392   1.00 40.25 ? 191 TRP A O   1 
ATOM   1377 C  CB  . TRP A 1 191 ? 59.452 -12.962 7.689   1.00 41.57 ? 191 TRP A CB  1 
ATOM   1378 C  CG  . TRP A 1 191 ? 58.539 -12.036 8.425   1.00 40.67 ? 191 TRP A CG  1 
ATOM   1379 C  CD1 . TRP A 1 191 ? 58.388 -10.694 8.240   1.00 40.51 ? 191 TRP A CD1 1 
ATOM   1380 C  CD2 . TRP A 1 191 ? 57.633 -12.401 9.477   1.00 37.86 ? 191 TRP A CD2 1 
ATOM   1381 N  NE1 . TRP A 1 191 ? 57.453 -10.201 9.107   1.00 40.95 ? 191 TRP A NE1 1 
ATOM   1382 C  CE2 . TRP A 1 191 ? 56.973 -11.224 9.878   1.00 38.37 ? 191 TRP A CE2 1 
ATOM   1383 C  CE3 . TRP A 1 191 ? 57.320 -13.604 10.117  1.00 37.64 ? 191 TRP A CE3 1 
ATOM   1384 C  CZ2 . TRP A 1 191 ? 56.017 -11.219 10.890  1.00 36.23 ? 191 TRP A CZ2 1 
ATOM   1385 C  CZ3 . TRP A 1 191 ? 56.376 -13.597 11.117  1.00 41.54 ? 191 TRP A CZ3 1 
ATOM   1386 C  CH2 . TRP A 1 191 ? 55.735 -12.419 11.496  1.00 37.24 ? 191 TRP A CH2 1 
ATOM   1387 N  N   . ALA A 1 192 ? 61.674 -13.949 5.413   1.00 38.63 ? 192 ALA A N   1 
ATOM   1388 C  CA  . ALA A 1 192 ? 62.835 -14.765 5.086   1.00 41.37 ? 192 ALA A CA  1 
ATOM   1389 C  C   . ALA A 1 192 ? 64.020 -13.903 4.704   1.00 39.46 ? 192 ALA A C   1 
ATOM   1390 O  O   . ALA A 1 192 ? 65.165 -14.341 4.859   1.00 41.74 ? 192 ALA A O   1 
ATOM   1391 C  CB  . ALA A 1 192 ? 62.497 -15.744 3.960   1.00 38.58 ? 192 ALA A CB  1 
ATOM   1392 N  N   . VAL A 1 193 ? 63.792 -12.674 4.244   1.00 44.23 ? 193 VAL A N   1 
ATOM   1393 C  CA  . VAL A 1 193 ? 64.933 -11.807 3.957   1.00 43.07 ? 193 VAL A CA  1 
ATOM   1394 C  C   . VAL A 1 193 ? 65.169 -10.749 5.041   1.00 50.33 ? 193 VAL A C   1 
ATOM   1395 O  O   . VAL A 1 193 ? 66.042 -9.882  4.880   1.00 48.84 ? 193 VAL A O   1 
ATOM   1396 C  CB  . VAL A 1 193 ? 64.803 -11.171 2.569   1.00 43.13 ? 193 VAL A CB  1 
ATOM   1397 C  CG1 . VAL A 1 193 ? 64.903 -12.257 1.512   1.00 47.00 ? 193 VAL A CG1 1 
ATOM   1398 C  CG2 . VAL A 1 193 ? 63.523 -10.409 2.443   1.00 45.00 ? 193 VAL A CG2 1 
ATOM   1399 N  N   . ASP A 1 194 ? 64.441 -10.806 6.149   1.00 46.18 ? 194 ASP A N   1 
ATOM   1400 C  CA  . ASP A 1 194 ? 64.643 -9.851  7.242   1.00 47.32 ? 194 ASP A CA  1 
ATOM   1401 C  C   . ASP A 1 194 ? 65.729 -10.421 8.143   1.00 48.95 ? 194 ASP A C   1 
ATOM   1402 O  O   . ASP A 1 194 ? 65.454 -11.190 9.060   1.00 45.95 ? 194 ASP A O   1 
ATOM   1403 C  CB  . ASP A 1 194 ? 63.334 -9.607  7.991   1.00 46.76 ? 194 ASP A CB  1 
ATOM   1404 C  CG  . ASP A 1 194 ? 63.463 -8.568  9.098   1.00 51.62 ? 194 ASP A CG  1 
ATOM   1405 O  OD1 . ASP A 1 194 ? 64.494 -7.870  9.183   1.00 53.42 ? 194 ASP A OD1 1 
ATOM   1406 O  OD2 . ASP A 1 194 ? 62.496 -8.421  9.871   1.00 48.16 ? 194 ASP A OD2 1 
ATOM   1407 N  N   . LYS A 1 195 ? 66.982 -10.027 7.880   1.00 54.58 ? 195 LYS A N   1 
ATOM   1408 C  CA  . LYS A 1 195 ? 68.136 -10.578 8.586   1.00 53.17 ? 195 LYS A CA  1 
ATOM   1409 C  C   . LYS A 1 195 ? 68.330 -9.885  9.928   1.00 56.00 ? 195 LYS A C   1 
ATOM   1410 O  O   . LYS A 1 195 ? 68.331 -8.651  10.007  1.00 55.41 ? 195 LYS A O   1 
ATOM   1411 C  CB  . LYS A 1 195 ? 69.412 -10.421 7.758   1.00 58.46 ? 195 LYS A CB  1 
ATOM   1412 C  CG  . LYS A 1 195 ? 69.239 -10.605 6.277   1.00 55.32 ? 195 LYS A CG  1 
ATOM   1413 C  CD  . LYS A 1 195 ? 70.352 -9.881  5.509   1.00 63.44 ? 195 LYS A CD  1 
ATOM   1414 C  CE  . LYS A 1 195 ? 69.965 -8.423  5.194   1.00 63.99 ? 195 LYS A CE  1 
ATOM   1415 N  NZ  . LYS A 1 195 ? 70.522 -7.919  3.891   1.00 62.62 ? 195 LYS A NZ  1 
ATOM   1416 N  N   . TYR A 1 196 ? 68.519 -10.681 10.978  1.00 53.74 ? 196 TYR A N   1 
ATOM   1417 C  CA  . TYR A 1 196 ? 68.853 -10.157 12.293  1.00 56.38 ? 196 TYR A CA  1 
ATOM   1418 C  C   . TYR A 1 196 ? 70.341 -9.812  12.335  1.00 58.75 ? 196 TYR A C   1 
ATOM   1419 O  O   . TYR A 1 196 ? 71.076 -10.048 11.371  1.00 61.17 ? 196 TYR A O   1 
ATOM   1420 C  CB  . TYR A 1 196 ? 68.485 -11.185 13.363  1.00 50.29 ? 196 TYR A CB  1 
ATOM   1421 C  CG  . TYR A 1 196 ? 66.992 -11.373 13.616  1.00 47.92 ? 196 TYR A CG  1 
ATOM   1422 C  CD1 . TYR A 1 196 ? 66.028 -10.638 12.921  1.00 50.45 ? 196 TYR A CD1 1 
ATOM   1423 C  CD2 . TYR A 1 196 ? 66.552 -12.286 14.563  1.00 50.35 ? 196 TYR A CD2 1 
ATOM   1424 C  CE1 . TYR A 1 196 ? 64.658 -10.827 13.172  1.00 47.80 ? 196 TYR A CE1 1 
ATOM   1425 C  CE2 . TYR A 1 196 ? 65.205 -12.479 14.814  1.00 47.19 ? 196 TYR A CE2 1 
ATOM   1426 C  CZ  . TYR A 1 196 ? 64.261 -11.745 14.126  1.00 44.90 ? 196 TYR A CZ  1 
ATOM   1427 O  OH  . TYR A 1 196 ? 62.915 -11.977 14.416  1.00 45.02 ? 196 TYR A OH  1 
ATOM   1428 N  N   . PRO A 1 197 ? 70.814 -9.200  13.423  1.00 59.87 ? 197 PRO A N   1 
ATOM   1429 C  CA  . PRO A 1 197 ? 72.267 -9.069  13.620  1.00 62.45 ? 197 PRO A CA  1 
ATOM   1430 C  C   . PRO A 1 197 ? 72.947 -10.426 13.747  1.00 63.95 ? 197 PRO A C   1 
ATOM   1431 O  O   . PRO A 1 197 ? 72.327 -11.433 14.097  1.00 65.32 ? 197 PRO A O   1 
ATOM   1432 C  CB  . PRO A 1 197 ? 72.383 -8.279  14.928  1.00 63.45 ? 197 PRO A CB  1 
ATOM   1433 C  CG  . PRO A 1 197 ? 71.091 -7.499  15.034  1.00 63.19 ? 197 PRO A CG  1 
ATOM   1434 C  CD  . PRO A 1 197 ? 70.057 -8.148  14.128  1.00 59.99 ? 197 PRO A CD  1 
ATOM   1435 N  N   . SER A 1 198 ? 74.253 -10.444 13.457  1.00 65.78 ? 198 SER A N   1 
ATOM   1436 C  CA  . SER A 1 198 ? 75.015 -11.682 13.605  1.00 65.58 ? 198 SER A CA  1 
ATOM   1437 C  C   . SER A 1 198 ? 74.990 -12.174 15.041  1.00 68.15 ? 198 SER A C   1 
ATOM   1438 O  O   . SER A 1 198 ? 74.999 -13.389 15.287  1.00 65.94 ? 198 SER A O   1 
ATOM   1439 C  CB  . SER A 1 198 ? 76.465 -11.475 13.169  1.00 68.30 ? 198 SER A CB  1 
ATOM   1440 O  OG  . SER A 1 198 ? 76.959 -10.221 13.622  1.00 71.40 ? 198 SER A OG  1 
ATOM   1441 N  N   . THR A 1 199 ? 74.958 -11.238 15.999  1.00 68.33 ? 199 THR A N   1 
ATOM   1442 C  CA  . THR A 1 199 ? 74.985 -11.573 17.418  1.00 69.35 ? 199 THR A CA  1 
ATOM   1443 C  C   . THR A 1 199 ? 73.695 -12.230 17.896  1.00 69.02 ? 199 THR A C   1 
ATOM   1444 O  O   . THR A 1 199 ? 73.727 -12.955 18.898  1.00 66.05 ? 199 THR A O   1 
ATOM   1445 C  CB  . THR A 1 199 ? 75.251 -10.315 18.246  1.00 71.16 ? 199 THR A CB  1 
ATOM   1446 O  OG1 . THR A 1 199 ? 74.056 -9.524  18.307  1.00 68.89 ? 199 THR A OG1 1 
ATOM   1447 C  CG2 . THR A 1 199 ? 76.369 -9.490  17.631  1.00 68.93 ? 199 THR A CG2 1 
ATOM   1448 N  N   . ALA A 1 200 ? 72.574 -11.997 17.207  1.00 66.25 ? 200 ALA A N   1 
ATOM   1449 C  CA  . ALA A 1 200 ? 71.287 -12.520 17.649  1.00 61.30 ? 200 ALA A CA  1 
ATOM   1450 C  C   . ALA A 1 200 ? 71.267 -14.043 17.604  1.00 59.03 ? 200 ALA A C   1 
ATOM   1451 O  O   . ALA A 1 200 ? 71.983 -14.677 16.824  1.00 65.13 ? 200 ALA A O   1 
ATOM   1452 C  CB  . ALA A 1 200 ? 70.151 -11.959 16.790  1.00 59.38 ? 200 ALA A CB  1 
ATOM   1453 N  N   . LYS A 1 201 ? 70.432 -14.631 18.469  1.00 53.43 ? 201 LYS A N   1 
ATOM   1454 C  CA  . LYS A 1 201 ? 70.310 -16.082 18.522  1.00 50.71 ? 201 LYS A CA  1 
ATOM   1455 C  C   . LYS A 1 201 ? 69.675 -16.640 17.255  1.00 52.11 ? 201 LYS A C   1 
ATOM   1456 O  O   . LYS A 1 201 ? 69.968 -17.774 16.866  1.00 51.47 ? 201 LYS A O   1 
ATOM   1457 C  CB  . LYS A 1 201 ? 69.491 -16.491 19.745  1.00 56.45 ? 201 LYS A CB  1 
ATOM   1458 C  CG  . LYS A 1 201 ? 69.206 -17.982 19.826  1.00 56.08 ? 201 LYS A CG  1 
ATOM   1459 C  CD  . LYS A 1 201 ? 68.161 -18.303 20.884  1.00 60.10 ? 201 LYS A CD  1 
ATOM   1460 C  CE  . LYS A 1 201 ? 68.677 -19.318 21.880  1.00 66.21 ? 201 LYS A CE  1 
ATOM   1461 N  NZ  . LYS A 1 201 ? 69.295 -18.651 23.070  1.00 73.05 ? 201 LYS A NZ  1 
ATOM   1462 N  N   . TYR A 1 202 ? 68.796 -15.874 16.615  1.00 54.18 ? 202 TYR A N   1 
ATOM   1463 C  CA  . TYR A 1 202 ? 68.112 -16.281 15.399  1.00 51.62 ? 202 TYR A CA  1 
ATOM   1464 C  C   . TYR A 1 202 ? 68.657 -15.472 14.238  1.00 45.09 ? 202 TYR A C   1 
ATOM   1465 O  O   . TYR A 1 202 ? 69.213 -14.386 14.404  1.00 50.69 ? 202 TYR A O   1 
ATOM   1466 C  CB  . TYR A 1 202 ? 66.582 -16.110 15.519  1.00 43.48 ? 202 TYR A CB  1 
ATOM   1467 C  CG  . TYR A 1 202 ? 65.955 -17.099 16.484  1.00 47.06 ? 202 TYR A CG  1 
ATOM   1468 C  CD1 . TYR A 1 202 ? 65.587 -18.369 16.070  1.00 41.09 ? 202 TYR A CD1 1 
ATOM   1469 C  CD2 . TYR A 1 202 ? 65.752 -16.773 17.821  1.00 47.41 ? 202 TYR A CD2 1 
ATOM   1470 C  CE1 . TYR A 1 202 ? 65.033 -19.280 16.952  1.00 44.20 ? 202 TYR A CE1 1 
ATOM   1471 C  CE2 . TYR A 1 202 ? 65.195 -17.687 18.708  1.00 46.05 ? 202 TYR A CE2 1 
ATOM   1472 C  CZ  . TYR A 1 202 ? 64.838 -18.929 18.271  1.00 43.89 ? 202 TYR A CZ  1 
ATOM   1473 O  OH  . TYR A 1 202 ? 64.269 -19.831 19.146  1.00 46.15 ? 202 TYR A OH  1 
ATOM   1474 N  N   . GLU A 1 203 ? 68.502 -16.015 13.046  1.00 47.57 ? 203 GLU A N   1 
ATOM   1475 C  CA  . GLU A 1 203 ? 69.140 -15.395 11.900  1.00 48.85 ? 203 GLU A CA  1 
ATOM   1476 C  C   . GLU A 1 203 ? 68.227 -14.465 11.121  1.00 46.64 ? 203 GLU A C   1 
ATOM   1477 O  O   . GLU A 1 203 ? 68.667 -13.396 10.674  1.00 44.84 ? 203 GLU A O   1 
ATOM   1478 C  CB  . GLU A 1 203 ? 69.670 -16.488 10.993  1.00 55.48 ? 203 GLU A CB  1 
ATOM   1479 C  CG  . GLU A 1 203 ? 71.146 -16.394 10.892  1.00 53.79 ? 203 GLU A CG  1 
ATOM   1480 C  CD  . GLU A 1 203 ? 71.702 -17.488 10.067  1.00 58.01 ? 203 GLU A CD  1 
ATOM   1481 O  OE1 . GLU A 1 203 ? 71.411 -17.522 8.851   1.00 58.26 ? 203 GLU A OE1 1 
ATOM   1482 O  OE2 . GLU A 1 203 ? 72.441 -18.317 10.651  1.00 59.24 ? 203 GLU A OE2 1 
ATOM   1483 N  N   . THR A 1 204 ? 66.964 -14.848 10.949  1.00 44.54 ? 204 THR A N   1 
ATOM   1484 C  CA  . THR A 1 204 ? 65.994 -14.056 10.209  1.00 44.49 ? 204 THR A CA  1 
ATOM   1485 C  C   . THR A 1 204 ? 64.718 -13.970 11.023  1.00 41.36 ? 204 THR A C   1 
ATOM   1486 O  O   . THR A 1 204 ? 64.499 -14.762 11.938  1.00 39.03 ? 204 THR A O   1 
ATOM   1487 C  CB  . THR A 1 204 ? 65.657 -14.673 8.848   1.00 42.16 ? 204 THR A CB  1 
ATOM   1488 O  OG1 . THR A 1 204 ? 65.083 -15.964 9.074   1.00 40.82 ? 204 THR A OG1 1 
ATOM   1489 C  CG2 . THR A 1 204 ? 66.903 -14.828 7.976   1.00 46.38 ? 204 THR A CG2 1 
ATOM   1490 N  N   . ARG A 1 205 ? 63.854 -13.022 10.658  1.00 43.18 ? 205 ARG A N   1 
ATOM   1491 C  CA  . ARG A 1 205 ? 62.547 -12.990 11.303  1.00 40.15 ? 205 ARG A CA  1 
ATOM   1492 C  C   . ARG A 1 205 ? 61.764 -14.283 11.061  1.00 36.78 ? 205 ARG A C   1 
ATOM   1493 O  O   . ARG A 1 205 ? 61.029 -14.745 11.938  1.00 37.31 ? 205 ARG A O   1 
ATOM   1494 C  CB  . ARG A 1 205 ? 61.741 -11.784 10.831  1.00 42.04 ? 205 ARG A CB  1 
ATOM   1495 C  CG  . ARG A 1 205 ? 60.505 -11.645 11.702  1.00 41.70 ? 205 ARG A CG  1 
ATOM   1496 C  CD  . ARG A 1 205 ? 59.872 -10.316 11.600  1.00 47.19 ? 205 ARG A CD  1 
ATOM   1497 N  NE  . ARG A 1 205 ? 58.881 -10.166 12.655  1.00 47.93 ? 205 ARG A NE  1 
ATOM   1498 C  CZ  . ARG A 1 205 ? 58.057 -9.133  12.732  1.00 47.63 ? 205 ARG A CZ  1 
ATOM   1499 N  NH1 . ARG A 1 205 ? 58.095 -8.157  11.838  1.00 47.46 ? 205 ARG A NH1 1 
ATOM   1500 N  NH2 . ARG A 1 205 ? 57.144 -9.102  13.698  1.00 47.16 ? 205 ARG A NH2 1 
ATOM   1501 N  N   . LEU A 1 206 ? 61.900 -14.881 9.873   1.00 39.57 ? 206 LEU A N   1 
ATOM   1502 C  CA  . LEU A 1 206 ? 61.229 -16.155 9.606   1.00 35.60 ? 206 LEU A CA  1 
ATOM   1503 C  C   . LEU A 1 206 ? 61.788 -17.277 10.467  1.00 39.49 ? 206 LEU A C   1 
ATOM   1504 O  O   . LEU A 1 206 ? 61.045 -18.159 10.914  1.00 38.54 ? 206 LEU A O   1 
ATOM   1505 C  CB  . LEU A 1 206 ? 61.367 -16.517 8.118   1.00 35.68 ? 206 LEU A CB  1 
ATOM   1506 C  CG  . LEU A 1 206 ? 60.616 -17.746 7.583   1.00 39.87 ? 206 LEU A CG  1 
ATOM   1507 C  CD1 . LEU A 1 206 ? 59.172 -17.416 7.271   1.00 39.93 ? 206 LEU A CD1 1 
ATOM   1508 C  CD2 . LEU A 1 206 ? 61.296 -18.277 6.324   1.00 42.46 ? 206 LEU A CD2 1 
ATOM   1509 N  N   . SER A 1 207 ? 63.100 -17.295 10.678  1.00 39.14 ? 207 SER A N   1 
ATOM   1510 C  CA  . SER A 1 207 ? 63.670 -18.409 11.416  1.00 41.37 ? 207 SER A CA  1 
ATOM   1511 C  C   . SER A 1 207 ? 63.297 -18.360 12.891  1.00 40.03 ? 207 SER A C   1 
ATOM   1512 O  O   . SER A 1 207 ? 63.370 -19.391 13.569  1.00 39.85 ? 207 SER A O   1 
ATOM   1513 C  CB  . SER A 1 207 ? 65.193 -18.455 11.230  1.00 41.97 ? 207 SER A CB  1 
ATOM   1514 O  OG  . SER A 1 207 ? 65.894 -17.580 12.093  1.00 46.95 ? 207 SER A OG  1 
ATOM   1515 N  N   . SER A 1 208 ? 62.858 -17.202 13.389  1.00 41.65 ? 208 SER A N   1 
ATOM   1516 C  CA  . SER A 1 208 ? 62.445 -17.081 14.786  1.00 41.60 ? 208 SER A CA  1 
ATOM   1517 C  C   . SER A 1 208 ? 61.071 -17.677 15.064  1.00 40.09 ? 208 SER A C   1 
ATOM   1518 O  O   . SER A 1 208 ? 60.685 -17.776 16.235  1.00 44.01 ? 208 SER A O   1 
ATOM   1519 C  CB  . SER A 1 208 ? 62.468 -15.611 15.207  1.00 40.25 ? 208 SER A CB  1 
ATOM   1520 O  OG  . SER A 1 208 ? 61.458 -14.885 14.541  1.00 42.84 ? 208 SER A OG  1 
ATOM   1521 N  N   . ILE A 1 209 ? 60.321 -18.082 14.040  1.00 36.85 ? 209 ILE A N   1 
ATOM   1522 C  CA  . ILE A 1 209 ? 59.055 -18.777 14.259  1.00 34.60 ? 209 ILE A CA  1 
ATOM   1523 C  C   . ILE A 1 209 ? 59.351 -20.177 14.786  1.00 38.68 ? 209 ILE A C   1 
ATOM   1524 O  O   . ILE A 1 209 ? 59.854 -21.018 14.039  1.00 36.61 ? 209 ILE A O   1 
ATOM   1525 C  CB  . ILE A 1 209 ? 58.212 -18.863 12.984  1.00 34.25 ? 209 ILE A CB  1 
ATOM   1526 C  CG1 . ILE A 1 209 ? 57.944 -17.480 12.390  1.00 34.81 ? 209 ILE A CG1 1 
ATOM   1527 C  CG2 . ILE A 1 209 ? 56.906 -19.610 13.301  1.00 33.88 ? 209 ILE A CG2 1 
ATOM   1528 C  CD1 . ILE A 1 209 ? 57.181 -17.571 11.070  1.00 33.59 ? 209 ILE A CD1 1 
ATOM   1529 N  N   . SER A 1 210 ? 58.991 -20.451 16.043  1.00 33.94 ? 210 SER A N   1 
ATOM   1530 C  CA  . SER A 1 210 ? 59.241 -21.753 16.646  1.00 35.38 ? 210 SER A CA  1 
ATOM   1531 C  C   . SER A 1 210 ? 58.194 -22.766 16.225  1.00 37.30 ? 210 SER A C   1 
ATOM   1532 O  O   . SER A 1 210 ? 58.487 -23.950 16.029  1.00 34.61 ? 210 SER A O   1 
ATOM   1533 C  CB  . SER A 1 210 ? 59.255 -21.615 18.175  1.00 37.01 ? 210 SER A CB  1 
ATOM   1534 O  OG  . SER A 1 210 ? 60.256 -20.708 18.581  1.00 42.09 ? 210 SER A OG  1 
ATOM   1535 N  N   . LEU A 1 211 ? 56.965 -22.312 16.062  1.00 32.88 ? 211 LEU A N   1 
ATOM   1536 C  CA  . LEU A 1 211 ? 55.855 -23.192 15.731  1.00 32.34 ? 211 LEU A CA  1 
ATOM   1537 C  C   . LEU A 1 211 ? 54.772 -22.300 15.166  1.00 34.64 ? 211 LEU A C   1 
ATOM   1538 O  O   . LEU A 1 211 ? 54.418 -21.315 15.816  1.00 34.15 ? 211 LEU A O   1 
ATOM   1539 C  CB  . LEU A 1 211 ? 55.320 -23.934 16.949  1.00 32.03 ? 211 LEU A CB  1 
ATOM   1540 C  CG  . LEU A 1 211 ? 54.157 -24.812 16.545  1.00 32.23 ? 211 LEU A CG  1 
ATOM   1541 C  CD1 . LEU A 1 211 ? 54.609 -25.845 15.532  1.00 35.99 ? 211 LEU A CD1 1 
ATOM   1542 C  CD2 . LEU A 1 211 ? 53.502 -25.473 17.732  1.00 33.51 ? 211 LEU A CD2 1 
ATOM   1543 N  N   . LEU A 1 212 ? 54.290 -22.622 13.965  1.00 33.99 ? 212 LEU A N   1 
ATOM   1544 C  CA  . LEU A 1 212 ? 53.197 -21.899 13.321  1.00 32.58 ? 212 LEU A CA  1 
ATOM   1545 C  C   . LEU A 1 212 ? 51.959 -22.771 13.350  1.00 31.01 ? 212 LEU A C   1 
ATOM   1546 O  O   . LEU A 1 212 ? 51.923 -23.835 12.734  1.00 32.15 ? 212 LEU A O   1 
ATOM   1547 C  CB  . LEU A 1 212 ? 53.535 -21.515 11.880  1.00 32.96 ? 212 LEU A CB  1 
ATOM   1548 C  CG  . LEU A 1 212 ? 52.590 -20.480 11.221  1.00 30.82 ? 212 LEU A CG  1 
ATOM   1549 C  CD1 . LEU A 1 212 ? 53.300 -19.660 10.165  1.00 32.65 ? 212 LEU A CD1 1 
ATOM   1550 C  CD2 . LEU A 1 212 ? 51.357 -21.136 10.635  1.00 29.53 ? 212 LEU A CD2 1 
ATOM   1551 N  N   . VAL A 1 213 ? 50.925 -22.313 14.035  1.00 28.31 ? 213 VAL A N   1 
ATOM   1552 C  CA  . VAL A 1 213 ? 49.668 -23.037 14.108  1.00 24.48 ? 213 VAL A CA  1 
ATOM   1553 C  C   . VAL A 1 213 ? 48.646 -22.274 13.283  1.00 32.39 ? 213 VAL A C   1 
ATOM   1554 O  O   . VAL A 1 213 ? 48.298 -21.138 13.629  1.00 32.34 ? 213 VAL A O   1 
ATOM   1555 C  CB  . VAL A 1 213 ? 49.167 -23.178 15.554  1.00 26.26 ? 213 VAL A CB  1 
ATOM   1556 C  CG1 . VAL A 1 213 ? 47.938 -24.034 15.564  1.00 28.78 ? 213 VAL A CG1 1 
ATOM   1557 C  CG2 . VAL A 1 213 ? 50.258 -23.777 16.495  1.00 32.28 ? 213 VAL A CG2 1 
ATOM   1558 N  N   . LEU A 1 214 ? 48.156 -22.884 12.220  1.00 29.24 ? 214 LEU A N   1 
ATOM   1559 C  CA  . LEU A 1 214 ? 47.215 -22.224 11.323  1.00 31.74 ? 214 LEU A CA  1 
ATOM   1560 C  C   . LEU A 1 214 ? 45.821 -22.779 11.589  1.00 31.15 ? 214 LEU A C   1 
ATOM   1561 O  O   . LEU A 1 214 ? 45.586 -23.979 11.418  1.00 30.33 ? 214 LEU A O   1 
ATOM   1562 C  CB  . LEU A 1 214 ? 47.638 -22.422 9.866   1.00 25.97 ? 214 LEU A CB  1 
ATOM   1563 C  CG  . LEU A 1 214 ? 46.588 -21.991 8.829   1.00 31.85 ? 214 LEU A CG  1 
ATOM   1564 C  CD1 . LEU A 1 214 ? 46.281 -20.485 9.009   1.00 30.57 ? 214 LEU A CD1 1 
ATOM   1565 C  CD2 . LEU A 1 214 ? 47.114 -22.276 7.419   1.00 29.85 ? 214 LEU A CD2 1 
ATOM   1566 N  N   . LEU A 1 215 ? 44.873 -21.904 11.962  1.00 29.80 ? 215 LEU A N   1 
ATOM   1567 C  CA  . LEU A 1 215 ? 43.477 -22.294 12.167  1.00 29.58 ? 215 LEU A CA  1 
ATOM   1568 C  C   . LEU A 1 215 ? 42.664 -21.948 10.925  1.00 27.80 ? 215 LEU A C   1 
ATOM   1569 O  O   . LEU A 1 215 ? 42.809 -20.847 10.399  1.00 31.53 ? 215 LEU A O   1 
ATOM   1570 C  CB  . LEU A 1 215 ? 42.876 -21.572 13.390  1.00 33.37 ? 215 LEU A CB  1 
ATOM   1571 C  CG  . LEU A 1 215 ? 43.625 -21.672 14.715  1.00 31.94 ? 215 LEU A CG  1 
ATOM   1572 C  CD1 . LEU A 1 215 ? 42.788 -21.062 15.889  1.00 32.09 ? 215 LEU A CD1 1 
ATOM   1573 C  CD2 . LEU A 1 215 ? 43.980 -23.162 14.971  1.00 32.60 ? 215 LEU A CD2 1 
ATOM   1574 N  N   . ASP A 1 216 ? 41.845 -22.887 10.438  1.00 35.06 ? 216 ASP A N   1 
ATOM   1575 C  CA  . ASP A 1 216 ? 41.052 -22.621 9.234   1.00 34.38 ? 216 ASP A CA  1 
ATOM   1576 C  C   . ASP A 1 216 ? 39.793 -23.478 9.234   1.00 36.10 ? 216 ASP A C   1 
ATOM   1577 O  O   . ASP A 1 216 ? 39.821 -24.632 9.646   1.00 38.05 ? 216 ASP A O   1 
ATOM   1578 C  CB  . ASP A 1 216 ? 41.867 -22.892 7.946   1.00 33.85 ? 216 ASP A CB  1 
ATOM   1579 C  CG  . ASP A 1 216 ? 41.287 -22.181 6.697   1.00 39.89 ? 216 ASP A CG  1 
ATOM   1580 O  OD1 . ASP A 1 216 ? 40.193 -21.595 6.769   1.00 40.07 ? 216 ASP A OD1 1 
ATOM   1581 O  OD2 . ASP A 1 216 ? 41.928 -22.199 5.627   1.00 33.71 ? 216 ASP A OD2 1 
ATOM   1582 N  N   . LEU A 1 217 ? 38.675 -22.893 8.796   1.00 38.48 ? 217 LEU A N   1 
ATOM   1583 C  CA  . LEU A 1 217 ? 37.424 -23.633 8.626   1.00 33.25 ? 217 LEU A CA  1 
ATOM   1584 C  C   . LEU A 1 217 ? 36.960 -24.287 9.932   1.00 39.58 ? 217 LEU A C   1 
ATOM   1585 O  O   . LEU A 1 217 ? 36.603 -25.467 9.961   1.00 40.06 ? 217 LEU A O   1 
ATOM   1586 C  CB  . LEU A 1 217 ? 37.555 -24.684 7.518   1.00 36.58 ? 217 LEU A CB  1 
ATOM   1587 C  CG  . LEU A 1 217 ? 38.146 -24.269 6.180   1.00 37.52 ? 217 LEU A CG  1 
ATOM   1588 C  CD1 . LEU A 1 217 ? 37.961 -25.381 5.153   1.00 35.27 ? 217 LEU A CD1 1 
ATOM   1589 C  CD2 . LEU A 1 217 ? 37.436 -23.009 5.720   1.00 38.84 ? 217 LEU A CD2 1 
ATOM   1590 N  N   . LEU A 1 218 ? 36.963 -23.511 11.019  1.00 35.25 ? 218 LEU A N   1 
ATOM   1591 C  CA  . LEU A 1 218 ? 36.467 -23.961 12.311  1.00 37.12 ? 218 LEU A CA  1 
ATOM   1592 C  C   . LEU A 1 218 ? 35.188 -23.224 12.677  1.00 40.13 ? 218 LEU A C   1 
ATOM   1593 O  O   . LEU A 1 218 ? 35.019 -22.042 12.353  1.00 34.65 ? 218 LEU A O   1 
ATOM   1594 C  CB  . LEU A 1 218 ? 37.485 -23.731 13.421  1.00 35.02 ? 218 LEU A CB  1 
ATOM   1595 C  CG  . LEU A 1 218 ? 38.850 -24.222 12.979  1.00 38.56 ? 218 LEU A CG  1 
ATOM   1596 C  CD1 . LEU A 1 218 ? 39.907 -23.817 13.978  1.00 37.44 ? 218 LEU A CD1 1 
ATOM   1597 C  CD2 . LEU A 1 218 ? 38.771 -25.739 12.782  1.00 36.63 ? 218 LEU A CD2 1 
ATOM   1598 N  N   . GLY A 1 219 ? 34.311 -23.925 13.389  1.00 40.85 ? 219 GLY A N   1 
ATOM   1599 C  CA  . GLY A 1 219 ? 33.061 -23.341 13.833  1.00 35.95 ? 219 GLY A CA  1 
ATOM   1600 C  C   . GLY A 1 219 ? 31.900 -24.203 13.416  1.00 43.00 ? 219 GLY A C   1 
ATOM   1601 O  O   . GLY A 1 219 ? 30.773 -23.955 13.826  1.00 46.07 ? 219 GLY A O   1 
ATOM   1602 N  N   . ALA A 1 220 ? 32.144 -25.200 12.579  1.00 40.63 ? 220 ALA A N   1 
ATOM   1603 C  CA  . ALA A 1 220 ? 31.082 -26.145 12.279  1.00 45.76 ? 220 ALA A CA  1 
ATOM   1604 C  C   . ALA A 1 220 ? 31.122 -27.289 13.290  1.00 46.21 ? 220 ALA A C   1 
ATOM   1605 O  O   . ALA A 1 220 ? 32.126 -27.500 13.981  1.00 43.24 ? 220 ALA A O   1 
ATOM   1606 C  CB  . ALA A 1 220 ? 31.200 -26.666 10.849  1.00 43.77 ? 220 ALA A CB  1 
ATOM   1607 N  N   . LYS A 1 221 ? 30.000 -28.006 13.394  1.00 43.53 ? 221 LYS A N   1 
ATOM   1608 C  CA  . LYS A 1 221 ? 29.896 -29.104 14.346  1.00 45.38 ? 221 LYS A CA  1 
ATOM   1609 C  C   . LYS A 1 221 ? 30.751 -30.275 13.898  1.00 45.37 ? 221 LYS A C   1 
ATOM   1610 O  O   . LYS A 1 221 ? 30.957 -30.498 12.702  1.00 50.26 ? 221 LYS A O   1 
ATOM   1611 C  CB  . LYS A 1 221 ? 28.455 -29.596 14.476  1.00 46.24 ? 221 LYS A CB  1 
ATOM   1612 C  CG  . LYS A 1 221 ? 27.470 -28.604 15.053  1.00 53.20 ? 221 LYS A CG  1 
ATOM   1613 C  CD  . LYS A 1 221 ? 26.203 -29.308 15.560  1.00 52.83 ? 221 LYS A CD  1 
ATOM   1614 C  CE  . LYS A 1 221 ? 25.596 -30.198 14.476  1.00 59.76 ? 221 LYS A CE  1 
ATOM   1615 N  NZ  . LYS A 1 221 ? 24.104 -30.090 14.390  1.00 61.70 ? 221 LYS A NZ  1 
ATOM   1616 N  N   . ASN A 1 222 ? 31.218 -31.044 14.876  1.00 49.37 ? 222 ASN A N   1 
ATOM   1617 C  CA  . ASN A 1 222 ? 31.898 -32.311 14.636  1.00 46.08 ? 222 ASN A CA  1 
ATOM   1618 C  C   . ASN A 1 222 ? 33.045 -32.201 13.629  1.00 45.79 ? 222 ASN A C   1 
ATOM   1619 O  O   . ASN A 1 222 ? 33.082 -32.938 12.638  1.00 49.27 ? 222 ASN A O   1 
ATOM   1620 C  CB  . ASN A 1 222 ? 30.894 -33.358 14.180  1.00 46.71 ? 222 ASN A CB  1 
ATOM   1621 C  CG  . ASN A 1 222 ? 29.778 -33.530 15.169  1.00 53.43 ? 222 ASN A CG  1 
ATOM   1622 O  OD1 . ASN A 1 222 ? 30.013 -33.560 16.377  1.00 52.56 ? 222 ASN A OD1 1 
ATOM   1623 N  ND2 . ASN A 1 222 ? 28.557 -33.628 14.672  1.00 47.69 ? 222 ASN A ND2 1 
ATOM   1624 N  N   . PRO A 1 223 ? 34.003 -31.314 13.861  1.00 48.57 ? 223 PRO A N   1 
ATOM   1625 C  CA  . PRO A 1 223 ? 35.115 -31.210 12.924  1.00 42.81 ? 223 PRO A CA  1 
ATOM   1626 C  C   . PRO A 1 223 ? 35.972 -32.467 12.977  1.00 46.32 ? 223 PRO A C   1 
ATOM   1627 O  O   . PRO A 1 223 ? 35.957 -33.235 13.942  1.00 46.43 ? 223 PRO A O   1 
ATOM   1628 C  CB  . PRO A 1 223 ? 35.874 -29.974 13.408  1.00 38.96 ? 223 PRO A CB  1 
ATOM   1629 C  CG  . PRO A 1 223 ? 35.638 -29.957 14.870  1.00 47.08 ? 223 PRO A CG  1 
ATOM   1630 C  CD  . PRO A 1 223 ? 34.233 -30.504 15.071  1.00 43.19 ? 223 PRO A CD  1 
ATOM   1631 N  N   . GLN A 1 224 ? 36.693 -32.686 11.890  1.00 46.30 ? 224 GLN A N   1 
ATOM   1632 C  CA  . GLN A 1 224 ? 37.674 -33.750 11.791  1.00 47.76 ? 224 GLN A CA  1 
ATOM   1633 C  C   . GLN A 1 224 ? 39.008 -33.101 11.464  1.00 41.12 ? 224 GLN A C   1 
ATOM   1634 O  O   . GLN A 1 224 ? 39.136 -32.424 10.439  1.00 39.17 ? 224 GLN A O   1 
ATOM   1635 C  CB  . GLN A 1 224 ? 37.256 -34.749 10.717  1.00 49.69 ? 224 GLN A CB  1 
ATOM   1636 C  CG  . GLN A 1 224 ? 35.898 -35.355 10.950  1.00 52.70 ? 224 GLN A CG  1 
ATOM   1637 C  CD  . GLN A 1 224 ? 35.462 -36.204 9.776   1.00 62.49 ? 224 GLN A CD  1 
ATOM   1638 O  OE1 . GLN A 1 224 ? 34.962 -35.677 8.773   1.00 65.73 ? 224 GLN A OE1 1 
ATOM   1639 N  NE2 . GLN A 1 224 ? 35.681 -37.510 9.869   1.00 54.19 ? 224 GLN A NE2 1 
ATOM   1640 N  N   . ILE A 1 225 ? 40.000 -33.299 12.331  1.00 40.90 ? 225 ILE A N   1 
ATOM   1641 C  CA  . ILE A 1 225 ? 41.301 -32.647 12.204  1.00 40.82 ? 225 ILE A CA  1 
ATOM   1642 C  C   . ILE A 1 225 ? 42.364 -33.723 12.037  1.00 41.11 ? 225 ILE A C   1 
ATOM   1643 O  O   . ILE A 1 225 ? 42.610 -34.512 12.959  1.00 38.68 ? 225 ILE A O   1 
ATOM   1644 C  CB  . ILE A 1 225 ? 41.607 -31.763 13.415  1.00 41.87 ? 225 ILE A CB  1 
ATOM   1645 C  CG1 . ILE A 1 225 ? 40.380 -30.906 13.733  1.00 36.86 ? 225 ILE A CG1 1 
ATOM   1646 C  CG2 . ILE A 1 225 ? 42.866 -30.949 13.175  1.00 37.55 ? 225 ILE A CG2 1 
ATOM   1647 C  CD1 . ILE A 1 225 ? 40.146 -29.770 12.702  1.00 35.87 ? 225 ILE A CD1 1 
ATOM   1648 N  N   . ALA A 1 226 ? 42.991 -33.759 10.871  1.00 38.56 ? 226 ALA A N   1 
ATOM   1649 C  CA  . ALA A 1 226 ? 44.053 -34.714 10.614  1.00 41.21 ? 226 ALA A CA  1 
ATOM   1650 C  C   . ALA A 1 226 ? 45.385 -34.058 10.924  1.00 38.35 ? 226 ALA A C   1 
ATOM   1651 O  O   . ALA A 1 226 ? 45.482 -32.834 11.033  1.00 33.94 ? 226 ALA A O   1 
ATOM   1652 C  CB  . ALA A 1 226 ? 44.026 -35.198 9.159   1.00 44.29 ? 226 ALA A CB  1 
ATOM   1653 N  N   . SER A 1 227 ? 46.421 -34.887 11.068  1.00 33.52 ? 227 SER A N   1 
ATOM   1654 C  CA  . SER A 1 227 ? 47.785 -34.401 11.243  1.00 34.07 ? 227 SER A CA  1 
ATOM   1655 C  C   . SER A 1 227 ? 48.474 -34.445 9.877   1.00 37.44 ? 227 SER A C   1 
ATOM   1656 O  O   . SER A 1 227 ? 48.556 -35.510 9.254   1.00 37.48 ? 227 SER A O   1 
ATOM   1657 C  CB  . SER A 1 227 ? 48.527 -35.248 12.290  1.00 29.85 ? 227 SER A CB  1 
ATOM   1658 O  OG  . SER A 1 227 ? 49.816 -34.744 12.523  1.00 32.45 ? 227 SER A OG  1 
ATOM   1659 N  N   . TYR A 1 228 ? 48.965 -33.297 9.400   1.00 35.89 ? 228 TYR A N   1 
ATOM   1660 C  CA  . TYR A 1 228 ? 49.458 -33.240 8.034   1.00 36.67 ? 228 TYR A CA  1 
ATOM   1661 C  C   . TYR A 1 228 ? 50.967 -33.153 7.920   1.00 32.15 ? 228 TYR A C   1 
ATOM   1662 O  O   . TYR A 1 228 ? 51.491 -33.315 6.806   1.00 34.68 ? 228 TYR A O   1 
ATOM   1663 C  CB  . TYR A 1 228 ? 48.860 -32.045 7.285   1.00 35.05 ? 228 TYR A CB  1 
ATOM   1664 C  CG  . TYR A 1 228 ? 47.384 -32.142 7.046   1.00 36.91 ? 228 TYR A CG  1 
ATOM   1665 C  CD1 . TYR A 1 228 ? 46.887 -32.783 5.929   1.00 38.82 ? 228 TYR A CD1 1 
ATOM   1666 C  CD2 . TYR A 1 228 ? 46.489 -31.554 7.928   1.00 37.44 ? 228 TYR A CD2 1 
ATOM   1667 C  CE1 . TYR A 1 228 ? 45.552 -32.857 5.703   1.00 36.31 ? 228 TYR A CE1 1 
ATOM   1668 C  CE2 . TYR A 1 228 ? 45.156 -31.612 7.720   1.00 35.79 ? 228 TYR A CE2 1 
ATOM   1669 C  CZ  . TYR A 1 228 ? 44.679 -32.254 6.601   1.00 40.21 ? 228 TYR A CZ  1 
ATOM   1670 O  OH  . TYR A 1 228 ? 43.329 -32.331 6.380   1.00 35.54 ? 228 TYR A OH  1 
ATOM   1671 N  N   . TYR A 1 229 ? 51.673 -32.871 9.007   1.00 30.58 ? 229 TYR A N   1 
ATOM   1672 C  CA  . TYR A 1 229 ? 53.109 -32.602 8.957   1.00 33.22 ? 229 TYR A CA  1 
ATOM   1673 C  C   . TYR A 1 229 ? 53.782 -33.469 10.011  1.00 36.30 ? 229 TYR A C   1 
ATOM   1674 O  O   . TYR A 1 229 ? 53.544 -33.265 11.222  1.00 31.89 ? 229 TYR A O   1 
ATOM   1675 C  CB  . TYR A 1 229 ? 53.405 -31.120 9.179   1.00 35.26 ? 229 TYR A CB  1 
ATOM   1676 C  CG  . TYR A 1 229 ? 52.874 -30.297 8.031   1.00 33.83 ? 229 TYR A CG  1 
ATOM   1677 C  CD1 . TYR A 1 229 ? 53.621 -30.122 6.884   1.00 36.42 ? 229 TYR A CD1 1 
ATOM   1678 C  CD2 . TYR A 1 229 ? 51.605 -29.742 8.079   1.00 33.92 ? 229 TYR A CD2 1 
ATOM   1679 C  CE1 . TYR A 1 229 ? 53.140 -29.400 5.806   1.00 40.25 ? 229 TYR A CE1 1 
ATOM   1680 C  CE2 . TYR A 1 229 ? 51.109 -29.023 6.995   1.00 30.53 ? 229 TYR A CE2 1 
ATOM   1681 C  CZ  . TYR A 1 229 ? 51.874 -28.868 5.862   1.00 37.13 ? 229 TYR A CZ  1 
ATOM   1682 O  OH  . TYR A 1 229 ? 51.382 -28.143 4.777   1.00 36.59 ? 229 TYR A OH  1 
ATOM   1683 N  N   . PRO A 1 230 ? 54.560 -34.475 9.604   1.00 39.66 ? 230 PRO A N   1 
ATOM   1684 C  CA  . PRO A 1 230 ? 55.297 -35.275 10.593  1.00 36.36 ? 230 PRO A CA  1 
ATOM   1685 C  C   . PRO A 1 230 ? 56.048 -34.437 11.586  1.00 33.56 ? 230 PRO A C   1 
ATOM   1686 O  O   . PRO A 1 230 ? 56.085 -34.762 12.785  1.00 36.43 ? 230 PRO A O   1 
ATOM   1687 C  CB  . PRO A 1 230 ? 56.273 -36.085 9.723   1.00 43.19 ? 230 PRO A CB  1 
ATOM   1688 C  CG  . PRO A 1 230 ? 55.653 -36.130 8.395   1.00 45.50 ? 230 PRO A CG  1 
ATOM   1689 C  CD  . PRO A 1 230 ? 54.920 -34.834 8.222   1.00 38.92 ? 230 PRO A CD  1 
ATOM   1690 N  N   . VAL A 1 231 ? 56.697 -33.375 11.109  1.00 31.78 ? 231 VAL A N   1 
ATOM   1691 C  CA  . VAL A 1 231 ? 57.587 -32.634 11.986  1.00 35.68 ? 231 VAL A CA  1 
ATOM   1692 C  C   . VAL A 1 231 ? 56.832 -31.981 13.150  1.00 39.45 ? 231 VAL A C   1 
ATOM   1693 O  O   . VAL A 1 231 ? 57.431 -31.737 14.207  1.00 39.32 ? 231 VAL A O   1 
ATOM   1694 C  CB  . VAL A 1 231 ? 58.397 -31.633 11.136  1.00 39.90 ? 231 VAL A CB  1 
ATOM   1695 C  CG1 . VAL A 1 231 ? 57.482 -30.887 10.200  1.00 47.13 ? 231 VAL A CG1 1 
ATOM   1696 C  CG2 . VAL A 1 231 ? 59.172 -30.661 12.006  1.00 44.06 ? 231 VAL A CG2 1 
ATOM   1697 N  N   . THR A 1 232 ? 55.515 -31.752 13.025  1.00 34.50 ? 232 THR A N   1 
ATOM   1698 C  CA  . THR A 1 232 ? 54.728 -31.266 14.163  1.00 32.14 ? 232 THR A CA  1 
ATOM   1699 C  C   . THR A 1 232 ? 53.738 -32.303 14.684  1.00 35.28 ? 232 THR A C   1 
ATOM   1700 O  O   . THR A 1 232 ? 52.816 -31.950 15.433  1.00 33.78 ? 232 THR A O   1 
ATOM   1701 C  CB  . THR A 1 232 ? 53.991 -29.965 13.816  1.00 34.37 ? 232 THR A CB  1 
ATOM   1702 O  OG1 . THR A 1 232 ? 53.203 -30.159 12.643  1.00 34.63 ? 232 THR A OG1 1 
ATOM   1703 C  CG2 . THR A 1 232 ? 54.987 -28.845 13.598  1.00 36.23 ? 232 THR A CG2 1 
ATOM   1704 N  N   . HIS A 1 233 ? 53.932 -33.599 14.374  1.00 33.96 ? 233 HIS A N   1 
ATOM   1705 C  CA  . HIS A 1 233 ? 52.948 -34.562 14.860  1.00 31.53 ? 233 HIS A CA  1 
ATOM   1706 C  C   . HIS A 1 233 ? 52.936 -34.635 16.385  1.00 31.09 ? 233 HIS A C   1 
ATOM   1707 O  O   . HIS A 1 233 ? 51.879 -34.869 16.987  1.00 34.67 ? 233 HIS A O   1 
ATOM   1708 C  CB  . HIS A 1 233 ? 53.186 -35.958 14.268  1.00 33.16 ? 233 HIS A CB  1 
ATOM   1709 C  CG  . HIS A 1 233 ? 52.061 -36.918 14.518  1.00 35.18 ? 233 HIS A CG  1 
ATOM   1710 N  ND1 . HIS A 1 233 ? 50.764 -36.671 14.119  1.00 38.45 ? 233 HIS A ND1 1 
ATOM   1711 C  CD2 . HIS A 1 233 ? 52.033 -38.119 15.141  1.00 35.25 ? 233 HIS A CD2 1 
ATOM   1712 C  CE1 . HIS A 1 233 ? 49.988 -37.679 14.477  1.00 38.22 ? 233 HIS A CE1 1 
ATOM   1713 N  NE2 . HIS A 1 233 ? 50.738 -38.575 15.093  1.00 37.16 ? 233 HIS A NE2 1 
ATOM   1714 N  N   . PHE A 1 234 ? 54.077 -34.420 17.028  1.00 33.98 ? 234 PHE A N   1 
ATOM   1715 C  CA  . PHE A 1 234 ? 54.071 -34.457 18.485  1.00 34.24 ? 234 PHE A CA  1 
ATOM   1716 C  C   . PHE A 1 234 ? 53.257 -33.291 19.032  1.00 36.04 ? 234 PHE A C   1 
ATOM   1717 O  O   . PHE A 1 234 ? 52.437 -33.480 19.937  1.00 36.15 ? 234 PHE A O   1 
ATOM   1718 C  CB  . PHE A 1 234 ? 55.492 -34.427 19.044  1.00 39.38 ? 234 PHE A CB  1 
ATOM   1719 C  CG  . PHE A 1 234 ? 55.533 -34.552 20.546  1.00 43.67 ? 234 PHE A CG  1 
ATOM   1720 C  CD1 . PHE A 1 234 ? 54.740 -35.495 21.194  1.00 44.49 ? 234 PHE A CD1 1 
ATOM   1721 C  CD2 . PHE A 1 234 ? 56.336 -33.718 21.307  1.00 48.87 ? 234 PHE A CD2 1 
ATOM   1722 C  CE1 . PHE A 1 234 ? 54.754 -35.618 22.584  1.00 50.49 ? 234 PHE A CE1 1 
ATOM   1723 C  CE2 . PHE A 1 234 ? 56.365 -33.831 22.688  1.00 54.18 ? 234 PHE A CE2 1 
ATOM   1724 C  CZ  . PHE A 1 234 ? 55.569 -34.787 23.330  1.00 51.20 ? 234 PHE A CZ  1 
ATOM   1725 N  N   . ASP A 1 235 ? 53.402 -32.101 18.425  1.00 37.26 ? 235 ASP A N   1 
ATOM   1726 C  CA  . ASP A 1 235 ? 52.543 -30.985 18.822  1.00 34.83 ? 235 ASP A CA  1 
ATOM   1727 C  C   . ASP A 1 235 ? 51.081 -31.341 18.613  1.00 31.53 ? 235 ASP A C   1 
ATOM   1728 O  O   . ASP A 1 235 ? 50.237 -31.083 19.480  1.00 36.54 ? 235 ASP A O   1 
ATOM   1729 C  CB  . ASP A 1 235 ? 52.901 -29.731 18.038  1.00 36.04 ? 235 ASP A CB  1 
ATOM   1730 C  CG  . ASP A 1 235 ? 54.355 -29.389 18.126  1.00 38.43 ? 235 ASP A CG  1 
ATOM   1731 O  OD1 . ASP A 1 235 ? 54.732 -28.669 19.061  1.00 39.76 ? 235 ASP A OD1 1 
ATOM   1732 O  OD2 . ASP A 1 235 ? 55.125 -29.837 17.247  1.00 39.94 ? 235 ASP A OD2 1 
ATOM   1733 N  N   . TYR A 1 236 ? 50.771 -31.988 17.482  1.00 30.91 ? 236 TYR A N   1 
ATOM   1734 C  CA  . TYR A 1 236 ? 49.411 -32.421 17.233  1.00 30.02 ? 236 TYR A CA  1 
ATOM   1735 C  C   . TYR A 1 236 ? 48.940 -33.326 18.355  1.00 35.54 ? 236 TYR A C   1 
ATOM   1736 O  O   . TYR A 1 236 ? 47.844 -33.156 18.904  1.00 37.15 ? 236 TYR A O   1 
ATOM   1737 C  CB  . TYR A 1 236 ? 49.357 -33.137 15.883  1.00 32.07 ? 236 TYR A CB  1 
ATOM   1738 C  CG  . TYR A 1 236 ? 48.038 -33.765 15.517  1.00 31.70 ? 236 TYR A CG  1 
ATOM   1739 C  CD1 . TYR A 1 236 ? 47.729 -35.045 15.915  1.00 32.64 ? 236 TYR A CD1 1 
ATOM   1740 C  CD2 . TYR A 1 236 ? 47.107 -33.088 14.702  1.00 31.47 ? 236 TYR A CD2 1 
ATOM   1741 C  CE1 . TYR A 1 236 ? 46.553 -35.641 15.567  1.00 35.56 ? 236 TYR A CE1 1 
ATOM   1742 C  CE2 . TYR A 1 236 ? 45.916 -33.695 14.337  1.00 30.52 ? 236 TYR A CE2 1 
ATOM   1743 C  CZ  . TYR A 1 236 ? 45.643 -34.971 14.778  1.00 35.15 ? 236 TYR A CZ  1 
ATOM   1744 O  OH  . TYR A 1 236 ? 44.471 -35.620 14.438  1.00 34.12 ? 236 TYR A OH  1 
ATOM   1745 N  N   . GLN A 1 237 ? 49.781 -34.292 18.741  1.00 33.71 ? 237 GLN A N   1 
ATOM   1746 C  CA  . GLN A 1 237 ? 49.328 -35.207 19.779  1.00 36.58 ? 237 GLN A CA  1 
ATOM   1747 C  C   . GLN A 1 237 ? 49.152 -34.485 21.103  1.00 32.87 ? 237 GLN A C   1 
ATOM   1748 O  O   . GLN A 1 237 ? 48.201 -34.790 21.836  1.00 37.06 ? 237 GLN A O   1 
ATOM   1749 C  CB  . GLN A 1 237 ? 50.304 -36.373 19.915  1.00 32.25 ? 237 GLN A CB  1 
ATOM   1750 C  CG  . GLN A 1 237 ? 50.342 -37.231 18.653  1.00 34.81 ? 237 GLN A CG  1 
ATOM   1751 C  CD  . GLN A 1 237 ? 51.422 -38.282 18.714  1.00 38.74 ? 237 GLN A CD  1 
ATOM   1752 O  OE1 . GLN A 1 237 ? 52.604 -37.958 18.947  1.00 38.67 ? 237 GLN A OE1 1 
ATOM   1753 N  NE2 . GLN A 1 237 ? 51.030 -39.554 18.521  1.00 33.64 ? 237 GLN A NE2 1 
ATOM   1754 N  N   . ARG A 1 238 ? 50.003 -33.483 21.389  1.00 36.63 ? 238 ARG A N   1 
ATOM   1755 C  CA  . ARG A 1 238 ? 49.793 -32.698 22.601  1.00 38.91 ? 238 ARG A CA  1 
ATOM   1756 C  C   . ARG A 1 238 ? 48.444 -31.994 22.546  1.00 38.35 ? 238 ARG A C   1 
ATOM   1757 O  O   . ARG A 1 238 ? 47.658 -32.044 23.504  1.00 37.87 ? 238 ARG A O   1 
ATOM   1758 C  CB  . ARG A 1 238 ? 50.926 -31.696 22.802  1.00 37.25 ? 238 ARG A CB  1 
ATOM   1759 C  CG  . ARG A 1 238 ? 52.248 -32.339 23.237  1.00 45.00 ? 238 ARG A CG  1 
ATOM   1760 C  CD  . ARG A 1 238 ? 53.071 -31.362 24.067  1.00 47.49 ? 238 ARG A CD  1 
ATOM   1761 N  NE  . ARG A 1 238 ? 53.170 -30.089 23.367  1.00 52.47 ? 238 ARG A NE  1 
ATOM   1762 C  CZ  . ARG A 1 238 ? 53.885 -29.865 22.270  1.00 49.72 ? 238 ARG A CZ  1 
ATOM   1763 N  NH1 . ARG A 1 238 ? 54.797 -30.732 21.841  1.00 51.22 ? 238 ARG A NH1 1 
ATOM   1764 N  NH2 . ARG A 1 238 ? 53.667 -28.750 21.573  1.00 46.02 ? 238 ARG A NH2 1 
ATOM   1765 N  N   . LEU A 1 239 ? 48.099 -31.413 21.403  1.00 39.16 ? 239 LEU A N   1 
ATOM   1766 C  CA  . LEU A 1 239 ? 46.789 -30.727 21.253  1.00 37.15 ? 239 LEU A CA  1 
ATOM   1767 C  C   . LEU A 1 239 ? 45.652 -31.720 21.499  1.00 38.64 ? 239 LEU A C   1 
ATOM   1768 O  O   . LEU A 1 239 ? 44.724 -31.383 22.231  1.00 40.54 ? 239 LEU A O   1 
ATOM   1769 C  CB  . LEU A 1 239 ? 46.701 -30.122 19.851  1.00 36.31 ? 239 LEU A CB  1 
ATOM   1770 C  CG  . LEU A 1 239 ? 45.454 -29.295 19.553  1.00 38.14 ? 239 LEU A CG  1 
ATOM   1771 C  CD1 . LEU A 1 239 ? 45.354 -28.106 20.493  1.00 34.94 ? 239 LEU A CD1 1 
ATOM   1772 C  CD2 . LEU A 1 239 ? 45.463 -28.828 18.107  1.00 35.47 ? 239 LEU A CD2 1 
ATOM   1773 N  N   . ALA A 1 240 ? 45.747 -32.911 20.923  1.00 37.73 ? 240 ALA A N   1 
ATOM   1774 C  CA  . ALA A 1 240 ? 44.667 -33.916 21.066  1.00 38.89 ? 240 ALA A CA  1 
ATOM   1775 C  C   . ALA A 1 240 ? 44.541 -34.362 22.525  1.00 38.39 ? 240 ALA A C   1 
ATOM   1776 O  O   . ALA A 1 240 ? 43.422 -34.606 22.972  1.00 41.93 ? 240 ALA A O   1 
ATOM   1777 C  CB  . ALA A 1 240 ? 44.946 -35.077 20.156  1.00 40.09 ? 240 ALA A CB  1 
ATOM   1778 N  N   . ALA A 1 241 ? 45.673 -34.474 23.215  1.00 42.70 ? 241 ALA A N   1 
ATOM   1779 C  CA  . ALA A 1 241 ? 45.662 -34.877 24.635  1.00 41.51 ? 241 ALA A CA  1 
ATOM   1780 C  C   . ALA A 1 241 ? 44.886 -33.836 25.438  1.00 45.36 ? 241 ALA A C   1 
ATOM   1781 O  O   . ALA A 1 241 ? 44.006 -34.213 26.205  1.00 47.45 ? 241 ALA A O   1 
ATOM   1782 C  CB  . ALA A 1 241 ? 47.068 -34.997 25.129  1.00 43.62 ? 241 ALA A CB  1 
ATOM   1783 N  N   . LEU A 1 242 ? 45.219 -32.564 25.239  1.00 43.06 ? 242 LEU A N   1 
ATOM   1784 C  CA  . LEU A 1 242 ? 44.527 -31.492 25.981  1.00 40.49 ? 242 LEU A CA  1 
ATOM   1785 C  C   . LEU A 1 242 ? 43.024 -31.601 25.702  1.00 41.78 ? 242 LEU A C   1 
ATOM   1786 O  O   . LEU A 1 242 ? 42.252 -31.525 26.654  1.00 51.20 ? 242 LEU A O   1 
ATOM   1787 C  CB  . LEU A 1 242 ? 45.123 -30.147 25.565  1.00 40.21 ? 242 LEU A CB  1 
ATOM   1788 C  CG  . LEU A 1 242 ? 46.523 -29.866 26.098  1.00 39.13 ? 242 LEU A CG  1 
ATOM   1789 C  CD1 . LEU A 1 242 ? 47.153 -28.697 25.364  1.00 39.58 ? 242 LEU A CD1 1 
ATOM   1790 C  CD2 . LEU A 1 242 ? 46.484 -29.598 27.593  1.00 39.52 ? 242 LEU A CD2 1 
ATOM   1791 N  N   . GLU A 1 243 ? 42.642 -31.836 24.453  1.00 41.34 ? 243 GLU A N   1 
ATOM   1792 C  CA  . GLU A 1 243 ? 41.206 -31.995 24.113  1.00 42.60 ? 243 GLU A CA  1 
ATOM   1793 C  C   . GLU A 1 243 ? 40.613 -33.146 24.911  1.00 50.28 ? 243 GLU A C   1 
ATOM   1794 O  O   . GLU A 1 243 ? 39.559 -32.951 25.524  1.00 51.08 ? 243 GLU A O   1 
ATOM   1795 C  CB  . GLU A 1 243 ? 41.011 -32.305 22.631  1.00 46.34 ? 243 GLU A CB  1 
ATOM   1796 C  CG  . GLU A 1 243 ? 39.558 -32.468 22.227  1.00 45.07 ? 243 GLU A CG  1 
ATOM   1797 C  CD  . GLU A 1 243 ? 39.289 -33.625 21.282  1.00 46.22 ? 243 GLU A CD  1 
ATOM   1798 O  OE1 . GLU A 1 243 ? 40.026 -34.619 21.347  1.00 46.60 ? 243 GLU A OE1 1 
ATOM   1799 O  OE2 . GLU A 1 243 ? 38.339 -33.529 20.490  1.00 49.33 ? 243 GLU A OE2 1 
ATOM   1800 N  N   . SER A 1 244 ? 41.276 -34.298 24.878  1.00 47.62 ? 244 SER A N   1 
ATOM   1801 C  CA  . SER A 1 244 ? 40.762 -35.498 25.578  1.00 50.79 ? 244 SER A CA  1 
ATOM   1802 C  C   . SER A 1 244 ? 40.597 -35.183 27.059  1.00 50.75 ? 244 SER A C   1 
ATOM   1803 O  O   . SER A 1 244 ? 39.523 -35.460 27.596  1.00 56.43 ? 244 SER A O   1 
ATOM   1804 C  CB  . SER A 1 244 ? 41.672 -36.670 25.358  1.00 45.60 ? 244 SER A CB  1 
ATOM   1805 O  OG  . SER A 1 244 ? 42.921 -36.475 25.993  1.00 53.43 ? 244 SER A OG  1 
ATOM   1806 N  N   . ARG A 1 245 ? 41.627 -34.617 27.670  1.00 50.24 ? 245 ARG A N   1 
ATOM   1807 C  CA  . ARG A 1 245 ? 41.588 -34.322 29.118  1.00 49.75 ? 245 ARG A CA  1 
ATOM   1808 C  C   . ARG A 1 245 ? 40.429 -33.370 29.396  1.00 59.33 ? 245 ARG A C   1 
ATOM   1809 O  O   . ARG A 1 245 ? 39.690 -33.616 30.356  1.00 61.90 ? 245 ARG A O   1 
ATOM   1810 C  CB  . ARG A 1 245 ? 42.919 -33.721 29.569  1.00 49.18 ? 245 ARG A CB  1 
ATOM   1811 C  CG  . ARG A 1 245 ? 44.127 -34.627 29.392  1.00 45.84 ? 245 ARG A CG  1 
ATOM   1812 C  CD  . ARG A 1 245 ? 45.389 -33.894 29.797  1.00 41.20 ? 245 ARG A CD  1 
ATOM   1813 N  NE  . ARG A 1 245 ? 45.302 -33.362 31.148  1.00 43.44 ? 245 ARG A NE  1 
ATOM   1814 C  CZ  . ARG A 1 245 ? 46.202 -32.558 31.700  1.00 47.88 ? 245 ARG A CZ  1 
ATOM   1815 N  NH1 . ARG A 1 245 ? 47.269 -32.188 31.015  1.00 45.16 ? 245 ARG A NH1 1 
ATOM   1816 N  NH2 . ARG A 1 245 ? 46.033 -32.128 32.936  1.00 52.44 ? 245 ARG A NH2 1 
ATOM   1817 N  N   . LEU A 1 246 ? 40.274 -32.335 28.570  1.00 53.75 ? 246 LEU A N   1 
ATOM   1818 C  CA  . LEU A 1 246 ? 39.190 -31.349 28.773  1.00 50.14 ? 246 LEU A CA  1 
ATOM   1819 C  C   . LEU A 1 246 ? 37.855 -32.084 28.681  1.00 58.05 ? 246 LEU A C   1 
ATOM   1820 O  O   . LEU A 1 246 ? 36.987 -31.823 29.519  1.00 61.72 ? 246 LEU A O   1 
ATOM   1821 C  CB  . LEU A 1 246 ? 39.308 -30.244 27.720  1.00 50.51 ? 246 LEU A CB  1 
ATOM   1822 C  CG  . LEU A 1 246 ? 40.408 -29.212 27.957  1.00 49.57 ? 246 LEU A CG  1 
ATOM   1823 C  CD1 . LEU A 1 246 ? 40.612 -28.347 26.725  1.00 43.87 ? 246 LEU A CD1 1 
ATOM   1824 C  CD2 . LEU A 1 246 ? 40.099 -28.348 29.169  1.00 52.67 ? 246 LEU A CD2 1 
ATOM   1825 N  N   . ARG A 1 247 ? 37.716 -32.979 27.705  1.00 55.98 ? 247 ARG A N   1 
ATOM   1826 C  CA  . ARG A 1 247 ? 36.438 -33.703 27.531  1.00 60.20 ? 247 ARG A CA  1 
ATOM   1827 C  C   . ARG A 1 247 ? 36.152 -34.479 28.815  1.00 67.07 ? 247 ARG A C   1 
ATOM   1828 O  O   . ARG A 1 247 ? 35.035 -34.354 29.338  1.00 69.67 ? 247 ARG A O   1 
ATOM   1829 C  CB  . ARG A 1 247 ? 36.478 -34.649 26.329  1.00 63.08 ? 247 ARG A CB  1 
ATOM   1830 C  CG  . ARG A 1 247 ? 35.105 -35.147 25.902  1.00 64.69 ? 247 ARG A CG  1 
ATOM   1831 C  CD  . ARG A 1 247 ? 35.142 -36.020 24.665  1.00 67.45 ? 247 ARG A CD  1 
ATOM   1832 N  NE  . ARG A 1 247 ? 34.951 -35.242 23.452  1.00 64.34 ? 247 ARG A NE  1 
ATOM   1833 C  CZ  . ARG A 1 247 ? 35.900 -35.000 22.558  1.00 60.90 ? 247 ARG A CZ  1 
ATOM   1834 N  NH1 . ARG A 1 247 ? 37.116 -35.483 22.737  1.00 55.93 ? 247 ARG A NH1 1 
ATOM   1835 N  NH2 . ARG A 1 247 ? 35.627 -34.278 21.487  1.00 60.19 ? 247 ARG A NH2 1 
ATOM   1836 N  N   . GLU A 1 248 ? 37.139 -35.231 29.302  1.00 65.64 ? 248 GLU A N   1 
ATOM   1837 C  CA  . GLU A 1 248 ? 36.973 -36.000 30.558  1.00 64.72 ? 248 GLU A CA  1 
ATOM   1838 C  C   . GLU A 1 248 ? 36.513 -35.053 31.660  1.00 67.48 ? 248 GLU A C   1 
ATOM   1839 O  O   . GLU A 1 248 ? 35.411 -35.256 32.183  1.00 72.12 ? 248 GLU A O   1 
ATOM   1840 C  CB  . GLU A 1 248 ? 38.296 -36.628 30.974  1.00 64.77 ? 248 GLU A CB  1 
ATOM   1841 C  CG  . GLU A 1 248 ? 38.946 -37.480 29.903  1.00 72.52 ? 248 GLU A CG  1 
ATOM   1842 C  CD  . GLU A 1 248 ? 40.070 -38.364 30.417  1.00 77.32 ? 248 GLU A CD  1 
ATOM   1843 O  OE1 . GLU A 1 248 ? 39.766 -39.443 30.960  1.00 81.83 ? 248 GLU A OE1 1 
ATOM   1844 O  OE2 . GLU A 1 248 ? 41.246 -37.970 30.281  1.00 69.42 ? 248 GLU A OE2 1 
ATOM   1845 N  N   . LEU A 1 249 ? 37.319 -34.042 31.977  1.00 63.68 ? 249 LEU A N   1 
ATOM   1846 C  CA  . LEU A 1 249 ? 36.988 -33.115 33.086  1.00 63.11 ? 249 LEU A CA  1 
ATOM   1847 C  C   . LEU A 1 249 ? 35.635 -32.439 32.838  1.00 62.24 ? 249 LEU A C   1 
ATOM   1848 O  O   . LEU A 1 249 ? 35.219 -31.653 33.697  1.00 62.89 ? 249 LEU A O   1 
ATOM   1849 C  CB  . LEU A 1 249 ? 38.115 -32.087 33.218  1.00 60.47 ? 249 LEU A CB  1 
ATOM   1850 C  CG  . LEU A 1 249 ? 39.527 -32.660 33.313  1.00 64.11 ? 249 LEU A CG  1 
ATOM   1851 C  CD1 . LEU A 1 249 ? 40.563 -31.548 33.305  1.00 61.76 ? 249 LEU A CD1 1 
ATOM   1852 C  CD2 . LEU A 1 249 ? 39.682 -33.521 34.557  1.00 64.70 ? 249 LEU A CD2 1 
ATOM   1853 N  N   . GLY A 1 250 ? 34.990 -32.718 31.708  1.00 63.27 ? 250 GLY A N   1 
ATOM   1854 C  CA  . GLY A 1 250 ? 33.651 -32.168 31.417  1.00 62.21 ? 250 GLY A CA  1 
ATOM   1855 C  C   . GLY A 1 250 ? 33.668 -30.690 31.077  1.00 66.66 ? 250 GLY A C   1 
ATOM   1856 O  O   . GLY A 1 250 ? 32.592 -30.069 31.137  1.00 65.47 ? 250 GLY A O   1 
ATOM   1857 N  N   . GLN A 1 251 ? 34.831 -30.140 30.735  1.00 59.82 ? 251 GLN A N   1 
ATOM   1858 C  CA  . GLN A 1 251 ? 34.939 -28.686 30.472  1.00 61.97 ? 251 GLN A CA  1 
ATOM   1859 C  C   . GLN A 1 251 ? 34.547 -28.384 29.022  1.00 60.39 ? 251 GLN A C   1 
ATOM   1860 O  O   . GLN A 1 251 ? 34.558 -27.207 28.646  1.00 60.94 ? 251 GLN A O   1 
ATOM   1861 C  CB  . GLN A 1 251 ? 36.353 -28.208 30.789  1.00 57.61 ? 251 GLN A CB  1 
ATOM   1862 C  CG  . GLN A 1 251 ? 36.683 -28.206 32.272  1.00 60.29 ? 251 GLN A CG  1 
ATOM   1863 C  CD  . GLN A 1 251 ? 36.618 -26.813 32.844  1.00 62.02 ? 251 GLN A CD  1 
ATOM   1864 O  OE1 . GLN A 1 251 ? 36.410 -26.620 34.038  1.00 66.47 ? 251 GLN A OE1 1 
ATOM   1865 N  NE2 . GLN A 1 251 ? 36.790 -25.821 31.986  1.00 63.86 ? 251 GLN A NE2 1 
ATOM   1866 N  N   . LEU A 1 252 ? 34.188 -29.410 28.256  1.00 59.86 ? 252 LEU A N   1 
ATOM   1867 C  CA  . LEU A 1 252 ? 33.830 -29.209 26.832  1.00 59.00 ? 252 LEU A CA  1 
ATOM   1868 C  C   . LEU A 1 252 ? 32.310 -29.141 26.708  1.00 60.45 ? 252 LEU A C   1 
ATOM   1869 O  O   . LEU A 1 252 ? 31.637 -30.024 27.252  1.00 58.30 ? 252 LEU A O   1 
ATOM   1870 C  CB  . LEU A 1 252 ? 34.417 -30.347 25.994  1.00 57.34 ? 252 LEU A CB  1 
ATOM   1871 C  CG  . LEU A 1 252 ? 35.932 -30.309 25.808  1.00 56.42 ? 252 LEU A CG  1 
ATOM   1872 C  CD1 . LEU A 1 252 ? 36.346 -31.154 24.616  1.00 54.29 ? 252 LEU A CD1 1 
ATOM   1873 C  CD2 . LEU A 1 252 ? 36.418 -28.878 25.643  1.00 53.82 ? 252 LEU A CD2 1 
ATOM   1874 N  N   . LYS A 1 253 ? 31.801 -28.139 25.998  1.00 56.34 ? 253 LYS A N   1 
ATOM   1875 C  CA  . LYS A 1 253 ? 30.338 -27.952 25.911  1.00 53.10 ? 253 LYS A CA  1 
ATOM   1876 C  C   . LYS A 1 253 ? 29.790 -28.708 24.709  1.00 58.46 ? 253 LYS A C   1 
ATOM   1877 O  O   . LYS A 1 253 ? 28.636 -29.133 24.771  1.00 62.86 ? 253 LYS A O   1 
ATOM   1878 C  CB  . LYS A 1 253 ? 30.003 -26.466 25.808  1.00 53.34 ? 253 LYS A CB  1 
ATOM   1879 C  CG  . LYS A 1 253 ? 30.706 -25.567 26.811  1.00 57.65 ? 253 LYS A CG  1 
ATOM   1880 C  CD  . LYS A 1 253 ? 30.373 -24.109 26.616  1.00 65.39 ? 253 LYS A CD  1 
ATOM   1881 C  CE  . LYS A 1 253 ? 30.022 -23.410 27.911  1.00 68.21 ? 253 LYS A CE  1 
ATOM   1882 N  NZ  . LYS A 1 253 ? 29.907 -24.369 29.034  1.00 69.68 ? 253 LYS A NZ  1 
ATOM   1883 N  N   . SER A 1 254 ? 30.584 -28.877 23.661  1.00 55.01 ? 254 SER A N   1 
ATOM   1884 C  CA  . SER A 1 254 ? 30.021 -29.509 22.471  1.00 58.91 ? 254 SER A CA  1 
ATOM   1885 C  C   . SER A 1 254 ? 30.057 -31.032 22.509  1.00 58.67 ? 254 SER A C   1 
ATOM   1886 O  O   . SER A 1 254 ? 29.552 -31.662 21.575  1.00 56.82 ? 254 SER A O   1 
ATOM   1887 C  CB  . SER A 1 254 ? 30.755 -29.021 21.221  1.00 56.46 ? 254 SER A CB  1 
ATOM   1888 O  OG  . SER A 1 254 ? 32.051 -29.589 21.164  1.00 55.76 ? 254 SER A OG  1 
ATOM   1889 N  N   . SER A 1 255 ? 30.639 -31.638 23.542  1.00 62.05 ? 255 SER A N   1 
ATOM   1890 C  CA  . SER A 1 255 ? 30.804 -33.084 23.615  1.00 66.22 ? 255 SER A CA  1 
ATOM   1891 C  C   . SER A 1 255 ? 30.492 -33.576 25.016  1.00 69.54 ? 255 SER A C   1 
ATOM   1892 O  O   . SER A 1 255 ? 30.888 -32.951 26.003  1.00 69.72 ? 255 SER A O   1 
ATOM   1893 C  CB  . SER A 1 255 ? 32.234 -33.519 23.265  1.00 65.66 ? 255 SER A CB  1 
ATOM   1894 O  OG  . SER A 1 255 ? 32.384 -33.852 21.898  1.00 66.32 ? 255 SER A OG  1 
ATOM   1895 N  N   . GLY A 1 256 ? 29.800 -34.709 25.098  1.00 75.56 ? 256 GLY A N   1 
ATOM   1896 C  CA  . GLY A 1 256 ? 29.692 -35.421 26.353  1.00 74.79 ? 256 GLY A CA  1 
ATOM   1897 C  C   . GLY A 1 256 ? 31.018 -36.077 26.703  1.00 75.20 ? 256 GLY A C   1 
ATOM   1898 O  O   . GLY A 1 256 ? 31.982 -36.063 25.934  1.00 72.20 ? 256 GLY A O   1 
ATOM   1899 N  N   . ILE A 1 257 ? 31.059 -36.677 27.898  1.00 76.08 ? 257 ILE A N   1 
ATOM   1900 C  CA  . ILE A 1 257 ? 32.294 -37.298 28.370  1.00 75.11 ? 257 ILE A CA  1 
ATOM   1901 C  C   . ILE A 1 257 ? 32.713 -38.465 27.480  1.00 72.81 ? 257 ILE A C   1 
ATOM   1902 O  O   . ILE A 1 257 ? 33.885 -38.849 27.479  1.00 74.71 ? 257 ILE A O   1 
ATOM   1903 C  CB  . ILE A 1 257 ? 32.157 -37.745 29.843  1.00 75.32 ? 257 ILE A CB  1 
ATOM   1904 C  CG1 . ILE A 1 257 ? 30.948 -38.666 30.031  1.00 77.84 ? 257 ILE A CG1 1 
ATOM   1905 C  CG2 . ILE A 1 257 ? 32.018 -36.525 30.750  1.00 73.11 ? 257 ILE A CG2 1 
ATOM   1906 C  CD1 . ILE A 1 257 ? 30.969 -39.441 31.342  1.00 78.65 ? 257 ILE A CD1 1 
ATOM   1907 N  N   . HIS A 1 258 ? 31.785 -39.027 26.703  1.00 72.02 ? 258 HIS A N   1 
ATOM   1908 C  CA  . HIS A 1 258 ? 32.080 -40.107 25.767  1.00 75.64 ? 258 HIS A CA  1 
ATOM   1909 C  C   . HIS A 1 258 ? 32.023 -39.654 24.307  1.00 74.41 ? 258 HIS A C   1 
ATOM   1910 O  O   . HIS A 1 258 ? 31.927 -40.492 23.407  1.00 68.60 ? 258 HIS A O   1 
ATOM   1911 C  CB  . HIS A 1 258 ? 31.123 -41.284 25.986  1.00 78.90 ? 258 HIS A CB  1 
ATOM   1912 C  CG  . HIS A 1 258 ? 31.157 -41.847 27.375  1.00 81.59 ? 258 HIS A CG  1 
ATOM   1913 N  ND1 . HIS A 1 258 ? 30.218 -41.527 28.334  1.00 85.71 ? 258 HIS A ND1 1 
ATOM   1914 C  CD2 . HIS A 1 258 ? 32.024 -42.702 27.970  1.00 81.82 ? 258 HIS A CD2 1 
ATOM   1915 C  CE1 . HIS A 1 258 ? 30.503 -42.164 29.457  1.00 85.78 ? 258 HIS A CE1 1 
ATOM   1916 N  NE2 . HIS A 1 258 ? 31.596 -42.881 29.264  1.00 82.91 ? 258 HIS A NE2 1 
ATOM   1917 N  N   . GLY A 1 259 ? 32.077 -38.349 24.050  1.00 73.77 ? 259 GLY A N   1 
ATOM   1918 C  CA  . GLY A 1 259 ? 32.096 -37.883 22.675  1.00 68.79 ? 259 GLY A CA  1 
ATOM   1919 C  C   . GLY A 1 259 ? 33.338 -38.355 21.941  1.00 65.98 ? 259 GLY A C   1 
ATOM   1920 O  O   . GLY A 1 259 ? 34.381 -38.628 22.545  1.00 64.75 ? 259 GLY A O   1 
ATOM   1921 N  N   . LYS A 1 260 ? 33.214 -38.466 20.616  1.00 61.21 ? 260 LYS A N   1 
ATOM   1922 C  CA  . LYS A 1 260 ? 34.337 -38.854 19.771  1.00 58.83 ? 260 LYS A CA  1 
ATOM   1923 C  C   . LYS A 1 260 ? 35.362 -37.714 19.690  1.00 58.82 ? 260 LYS A C   1 
ATOM   1924 O  O   . LYS A 1 260 ? 35.010 -36.530 19.726  1.00 58.94 ? 260 LYS A O   1 
ATOM   1925 C  CB  . LYS A 1 260 ? 33.817 -39.236 18.381  1.00 59.55 ? 260 LYS A CB  1 
ATOM   1926 C  CG  . LYS A 1 260 ? 34.812 -39.100 17.245  1.00 64.38 ? 260 LYS A CG  1 
ATOM   1927 C  CD  . LYS A 1 260 ? 34.687 -40.218 16.197  1.00 64.38 ? 260 LYS A CD  1 
ATOM   1928 C  CE  . LYS A 1 260 ? 33.732 -39.867 15.054  1.00 60.87 ? 260 LYS A CE  1 
ATOM   1929 N  NZ  . LYS A 1 260 ? 33.764 -40.902 13.959  1.00 66.47 ? 260 LYS A NZ  1 
ATOM   1930 N  N   . SER A 1 261 ? 36.645 -38.073 19.614  1.00 52.46 ? 261 SER A N   1 
ATOM   1931 C  CA  . SER A 1 261 ? 37.696 -37.063 19.518  1.00 48.55 ? 261 SER A CA  1 
ATOM   1932 C  C   . SER A 1 261 ? 37.756 -36.489 18.114  1.00 46.39 ? 261 SER A C   1 
ATOM   1933 O  O   . SER A 1 261 ? 37.623 -37.216 17.122  1.00 47.31 ? 261 SER A O   1 
ATOM   1934 C  CB  . SER A 1 261 ? 39.065 -37.638 19.873  1.00 46.61 ? 261 SER A CB  1 
ATOM   1935 O  OG  . SER A 1 261 ? 40.109 -36.736 19.520  1.00 43.85 ? 261 SER A OG  1 
ATOM   1936 N  N   . TRP A 1 262 ? 37.994 -35.179 18.033  1.00 43.34 ? 262 TRP A N   1 
ATOM   1937 C  CA  . TRP A 1 262 ? 38.149 -34.543 16.728  1.00 45.46 ? 262 TRP A CA  1 
ATOM   1938 C  C   . TRP A 1 262 ? 39.449 -34.926 16.047  1.00 43.55 ? 262 TRP A C   1 
ATOM   1939 O  O   . TRP A 1 262 ? 39.587 -34.747 14.831  1.00 43.95 ? 262 TRP A O   1 
ATOM   1940 C  CB  . TRP A 1 262 ? 38.133 -33.029 16.866  1.00 42.78 ? 262 TRP A CB  1 
ATOM   1941 C  CG  . TRP A 1 262 ? 36.927 -32.454 17.476  1.00 42.41 ? 262 TRP A CG  1 
ATOM   1942 C  CD1 . TRP A 1 262 ? 35.679 -33.007 17.550  1.00 48.35 ? 262 TRP A CD1 1 
ATOM   1943 C  CD2 . TRP A 1 262 ? 36.846 -31.184 18.114  1.00 41.55 ? 262 TRP A CD2 1 
ATOM   1944 N  NE1 . TRP A 1 262 ? 34.818 -32.139 18.192  1.00 45.72 ? 262 TRP A NE1 1 
ATOM   1945 C  CE2 . TRP A 1 262 ? 35.517 -31.015 18.551  1.00 45.77 ? 262 TRP A CE2 1 
ATOM   1946 C  CE3 . TRP A 1 262 ? 37.773 -30.165 18.356  1.00 43.72 ? 262 TRP A CE3 1 
ATOM   1947 C  CZ2 . TRP A 1 262 ? 35.096 -29.871 19.215  1.00 46.78 ? 262 TRP A CZ2 1 
ATOM   1948 C  CZ3 . TRP A 1 262 ? 37.352 -29.033 19.013  1.00 40.21 ? 262 TRP A CZ3 1 
ATOM   1949 C  CH2 . TRP A 1 262 ? 36.027 -28.891 19.434  1.00 40.81 ? 262 TRP A CH2 1 
ATOM   1950 N  N   . PHE A 1 263 ? 40.410 -35.433 16.794  1.00 44.84 ? 263 PHE A N   1 
ATOM   1951 C  CA  . PHE A 1 263 ? 41.761 -35.573 16.291  1.00 39.20 ? 263 PHE A CA  1 
ATOM   1952 C  C   . PHE A 1 263 ? 41.982 -37.004 15.836  1.00 45.00 ? 263 PHE A C   1 
ATOM   1953 O  O   . PHE A 1 263 ? 42.486 -37.847 16.585  1.00 42.74 ? 263 PHE A O   1 
ATOM   1954 C  CB  . PHE A 1 263 ? 42.739 -35.142 17.352  1.00 41.01 ? 263 PHE A CB  1 
ATOM   1955 C  CG  . PHE A 1 263 ? 42.643 -33.704 17.635  1.00 38.30 ? 263 PHE A CG  1 
ATOM   1956 C  CD1 . PHE A 1 263 ? 41.767 -33.240 18.585  1.00 41.53 ? 263 PHE A CD1 1 
ATOM   1957 C  CD2 . PHE A 1 263 ? 43.361 -32.803 16.868  1.00 39.54 ? 263 PHE A CD2 1 
ATOM   1958 C  CE1 . PHE A 1 263 ? 41.644 -31.892 18.816  1.00 41.60 ? 263 PHE A CE1 1 
ATOM   1959 C  CE2 . PHE A 1 263 ? 43.250 -31.452 17.093  1.00 39.30 ? 263 PHE A CE2 1 
ATOM   1960 C  CZ  . PHE A 1 263 ? 42.394 -30.998 18.072  1.00 36.42 ? 263 PHE A CZ  1 
ATOM   1961 N  N   . VAL A 1 264 ? 41.644 -37.244 14.566  1.00 41.02 ? 264 VAL A N   1 
ATOM   1962 C  CA  . VAL A 1 264 ? 41.540 -38.601 14.048  1.00 45.68 ? 264 VAL A CA  1 
ATOM   1963 C  C   . VAL A 1 264 ? 42.884 -39.288 13.970  1.00 38.40 ? 264 VAL A C   1 
ATOM   1964 O  O   . VAL A 1 264 ? 42.934 -40.516 13.900  1.00 44.69 ? 264 VAL A O   1 
ATOM   1965 C  CB  . VAL A 1 264 ? 40.886 -38.620 12.652  1.00 43.77 ? 264 VAL A CB  1 
ATOM   1966 C  CG1 . VAL A 1 264 ? 39.540 -37.926 12.682  1.00 45.92 ? 264 VAL A CG1 1 
ATOM   1967 C  CG2 . VAL A 1 264 ? 41.799 -37.988 11.637  1.00 43.32 ? 264 VAL A CG2 1 
ATOM   1968 N  N   . ASP A 1 265 ? 43.980 -38.541 13.906  1.00 37.79 ? 265 ASP A N   1 
ATOM   1969 C  CA  . ASP A 1 265 ? 45.291 -39.144 13.741  1.00 41.07 ? 265 ASP A CA  1 
ATOM   1970 C  C   . ASP A 1 265 ? 46.034 -39.269 15.061  1.00 39.99 ? 265 ASP A C   1 
ATOM   1971 O  O   . ASP A 1 265 ? 47.264 -39.402 15.057  1.00 41.72 ? 265 ASP A O   1 
ATOM   1972 C  CB  . ASP A 1 265 ? 46.129 -38.343 12.753  1.00 38.78 ? 265 ASP A CB  1 
ATOM   1973 C  CG  . ASP A 1 265 ? 45.643 -38.486 11.319  1.00 42.74 ? 265 ASP A CG  1 
ATOM   1974 O  OD1 . ASP A 1 265 ? 45.078 -39.528 10.963  1.00 44.94 ? 265 ASP A OD1 1 
ATOM   1975 O  OD2 . ASP A 1 265 ? 45.819 -37.540 10.543  1.00 39.51 ? 265 ASP A OD2 1 
ATOM   1976 N  N   . ARG A 1 266 ? 45.316 -39.209 16.187  1.00 38.77 ? 266 ARG A N   1 
ATOM   1977 C  CA  . ARG A 1 266 ? 45.993 -39.018 17.464  1.00 40.12 ? 266 ARG A CA  1 
ATOM   1978 C  C   . ARG A 1 266 ? 46.814 -40.239 17.853  1.00 45.60 ? 266 ARG A C   1 
ATOM   1979 O  O   . ARG A 1 266 ? 47.929 -40.088 18.370  1.00 50.03 ? 266 ARG A O   1 
ATOM   1980 C  CB  . ARG A 1 266 ? 44.972 -38.579 18.526  1.00 41.52 ? 266 ARG A CB  1 
ATOM   1981 C  CG  . ARG A 1 266 ? 44.020 -39.580 19.158  1.00 50.56 ? 266 ARG A CG  1 
ATOM   1982 C  CD  . ARG A 1 266 ? 43.469 -38.976 20.480  1.00 53.99 ? 266 ARG A CD  1 
ATOM   1983 N  NE  . ARG A 1 266 ? 44.577 -38.711 21.401  1.00 59.35 ? 266 ARG A NE  1 
ATOM   1984 C  CZ  . ARG A 1 266 ? 44.564 -38.928 22.715  1.00 59.91 ? 266 ARG A CZ  1 
ATOM   1985 N  NH1 . ARG A 1 266 ? 43.472 -39.333 23.340  1.00 60.56 ? 266 ARG A NH1 1 
ATOM   1986 N  NH2 . ARG A 1 266 ? 45.683 -38.742 23.418  1.00 54.86 ? 266 ARG A NH2 1 
ATOM   1987 N  N   . THR A 1 267 ? 46.357 -41.435 17.495  1.00 45.68 ? 267 THR A N   1 
ATOM   1988 C  CA  . THR A 1 267 ? 47.104 -42.662 17.778  1.00 51.10 ? 267 THR A CA  1 
ATOM   1989 C  C   . THR A 1 267 ? 48.044 -43.073 16.646  1.00 49.54 ? 267 THR A C   1 
ATOM   1990 O  O   . THR A 1 267 ? 48.815 -44.023 16.808  1.00 51.68 ? 267 THR A O   1 
ATOM   1991 C  CB  . THR A 1 267 ? 46.135 -43.814 18.079  1.00 49.42 ? 267 THR A CB  1 
ATOM   1992 O  OG1 . THR A 1 267 ? 45.536 -44.259 16.861  1.00 53.04 ? 267 THR A OG1 1 
ATOM   1993 C  CG2 . THR A 1 267 ? 45.036 -43.359 19.008  1.00 46.57 ? 267 THR A CG2 1 
ATOM   1994 N  N   . THR A 1 268 ? 48.025 -42.369 15.521  1.00 48.58 ? 268 THR A N   1 
ATOM   1995 C  CA  . THR A 1 268 ? 48.832 -42.764 14.382  1.00 43.90 ? 268 THR A CA  1 
ATOM   1996 C  C   . THR A 1 268 ? 50.299 -42.458 14.638  1.00 47.83 ? 268 THR A C   1 
ATOM   1997 O  O   . THR A 1 268 ? 50.646 -41.446 15.248  1.00 45.23 ? 268 THR A O   1 
ATOM   1998 C  CB  . THR A 1 268 ? 48.325 -42.062 13.109  1.00 43.18 ? 268 THR A CB  1 
ATOM   1999 O  OG1 . THR A 1 268 ? 46.902 -42.209 13.042  1.00 50.77 ? 268 THR A OG1 1 
ATOM   2000 C  CG2 . THR A 1 268 ? 48.931 -42.662 11.873  1.00 42.11 ? 268 THR A CG2 1 
ATOM   2001 N  N   . ASP A 1 269 ? 51.164 -43.371 14.207  1.00 47.84 ? 269 ASP A N   1 
ATOM   2002 C  CA  . ASP A 1 269 ? 52.588 -43.189 14.399  1.00 44.70 ? 269 ASP A CA  1 
ATOM   2003 C  C   . ASP A 1 269 ? 53.097 -42.118 13.451  1.00 48.77 ? 269 ASP A C   1 
ATOM   2004 O  O   . ASP A 1 269 ? 52.651 -42.034 12.308  1.00 52.37 ? 269 ASP A O   1 
ATOM   2005 C  CB  . ASP A 1 269 ? 53.327 -44.509 14.156  1.00 50.32 ? 269 ASP A CB  1 
ATOM   2006 C  CG  . ASP A 1 269 ? 54.775 -44.407 14.494  1.00 49.38 ? 269 ASP A CG  1 
ATOM   2007 O  OD1 . ASP A 1 269 ? 55.105 -44.645 15.677  1.00 53.26 ? 269 ASP A OD1 1 
ATOM   2008 O  OD2 . ASP A 1 269 ? 55.584 -44.059 13.600  1.00 51.59 ? 269 ASP A OD2 1 
ATOM   2009 N  N   . VAL A 1 270 ? 54.050 -41.308 13.919  1.00 46.11 ? 270 VAL A N   1 
ATOM   2010 C  CA  . VAL A 1 270 ? 54.548 -40.220 13.082  1.00 49.72 ? 270 VAL A CA  1 
ATOM   2011 C  C   . VAL A 1 270 ? 55.002 -40.751 11.730  1.00 57.34 ? 270 VAL A C   1 
ATOM   2012 O  O   . VAL A 1 270 ? 54.717 -40.159 10.685  1.00 55.26 ? 270 VAL A O   1 
ATOM   2013 C  CB  . VAL A 1 270 ? 55.677 -39.456 13.791  1.00 44.35 ? 270 VAL A CB  1 
ATOM   2014 C  CG1 . VAL A 1 270 ? 56.760 -40.407 14.283  1.00 56.29 ? 270 VAL A CG1 1 
ATOM   2015 C  CG2 . VAL A 1 270 ? 56.249 -38.412 12.866  1.00 46.82 ? 270 VAL A CG2 1 
ATOM   2016 N  N   . ARG A 1 271 ? 55.677 -41.893 11.719  1.00 57.32 ? 271 ARG A N   1 
ATOM   2017 C  CA  . ARG A 1 271 ? 56.256 -42.438 10.457  1.00 55.21 ? 271 ARG A CA  1 
ATOM   2018 C  C   . ARG A 1 271 ? 55.163 -43.140 9.653   1.00 54.03 ? 271 ARG A C   1 
ATOM   2019 O  O   . ARG A 1 271 ? 55.469 -43.593 8.549   1.00 59.24 ? 271 ARG A O   1 
ATOM   2020 C  CB  . ARG A 1 271 ? 57.439 -43.358 10.784  1.00 61.02 ? 271 ARG A CB  1 
ATOM   2021 C  CG  . ARG A 1 271 ? 58.762 -42.628 10.959  1.00 62.88 ? 271 ARG A CG  1 
ATOM   2022 N  N   . SER A 1 272 ? 53.940 -43.230 10.175  1.00 51.83 ? 272 SER A N   1 
ATOM   2023 C  CA  . SER A 1 272 ? 52.791 -43.815 9.499   1.00 54.51 ? 272 SER A CA  1 
ATOM   2024 C  C   . SER A 1 272 ? 51.830 -42.757 8.956   1.00 55.93 ? 272 SER A C   1 
ATOM   2025 O  O   . SER A 1 272 ? 50.748 -43.111 8.471   1.00 53.14 ? 272 SER A O   1 
ATOM   2026 C  CB  . SER A 1 272 ? 52.042 -44.749 10.453  1.00 56.58 ? 272 SER A CB  1 
ATOM   2027 O  OG  . SER A 1 272 ? 52.836 -45.870 10.821  1.00 61.56 ? 272 SER A OG  1 
ATOM   2028 N  N   . LEU A 1 273 ? 52.197 -41.472 9.051   1.00 56.17 ? 273 LEU A N   1 
ATOM   2029 C  CA  . LEU A 1 273 ? 51.355 -40.370 8.592   1.00 55.92 ? 273 LEU A CA  1 
ATOM   2030 C  C   . LEU A 1 273 ? 51.461 -40.246 7.084   1.00 56.36 ? 273 LEU A C   1 
ATOM   2031 O  O   . LEU A 1 273 ? 52.528 -39.893 6.563   1.00 58.15 ? 273 LEU A O   1 
ATOM   2032 C  CB  . LEU A 1 273 ? 51.775 -39.049 9.237   1.00 50.77 ? 273 LEU A CB  1 
ATOM   2033 C  CG  . LEU A 1 273 ? 51.316 -38.704 10.651  1.00 48.25 ? 273 LEU A CG  1 
ATOM   2034 C  CD1 . LEU A 1 273 ? 51.861 -37.306 11.001  1.00 45.51 ? 273 LEU A CD1 1 
ATOM   2035 C  CD2 . LEU A 1 273 ? 49.811 -38.773 10.778  1.00 45.04 ? 273 LEU A CD2 1 
ATOM   2036 N  N   . LYS A 1 274 ? 50.347 -40.492 6.396   1.00 54.26 ? 274 LYS A N   1 
ATOM   2037 C  CA  . LYS A 1 274 ? 50.283 -40.489 4.939   1.00 56.80 ? 274 LYS A CA  1 
ATOM   2038 C  C   . LYS A 1 274 ? 49.109 -39.630 4.458   1.00 55.57 ? 274 LYS A C   1 
ATOM   2039 O  O   . LYS A 1 274 ? 48.231 -40.104 3.741   1.00 61.36 ? 274 LYS A O   1 
ATOM   2040 C  CB  . LYS A 1 274 ? 50.120 -41.908 4.371   1.00 60.81 ? 274 LYS A CB  1 
ATOM   2041 C  CG  . LYS A 1 274 ? 51.402 -42.685 4.115   1.00 62.08 ? 274 LYS A CG  1 
ATOM   2042 C  CD  . LYS A 1 274 ? 51.162 -44.032 3.454   1.00 65.95 ? 274 LYS A CD  1 
ATOM   2043 C  CE  . LYS A 1 274 ? 50.964 -45.135 4.491   1.00 70.33 ? 274 LYS A CE  1 
ATOM   2044 N  NZ  . LYS A 1 274 ? 49.786 -45.995 4.173   1.00 74.62 ? 274 LYS A NZ  1 
ATOM   2045 N  N   . ARG A 1 275 ? 49.075 -38.355 4.817   1.00 51.32 ? 275 ARG A N   1 
ATOM   2046 C  CA  . ARG A 1 275 ? 48.022 -37.511 4.266   1.00 49.83 ? 275 ARG A CA  1 
ATOM   2047 C  C   . ARG A 1 275 ? 48.591 -36.335 3.487   1.00 40.79 ? 275 ARG A C   1 
ATOM   2048 O  O   . ARG A 1 275 ? 49.615 -35.747 3.847   1.00 46.63 ? 275 ARG A O   1 
ATOM   2049 C  CB  . ARG A 1 275 ? 47.009 -37.086 5.337   1.00 46.46 ? 275 ARG A CB  1 
ATOM   2050 C  CG  . ARG A 1 275 ? 47.522 -36.979 6.722   1.00 49.83 ? 275 ARG A CG  1 
ATOM   2051 C  CD  . ARG A 1 275 ? 46.614 -37.820 7.643   1.00 53.66 ? 275 ARG A CD  1 
ATOM   2052 N  NE  . ARG A 1 275 ? 45.276 -38.012 7.089   1.00 54.31 ? 275 ARG A NE  1 
ATOM   2053 C  CZ  . ARG A 1 275 ? 44.415 -38.966 7.440   1.00 54.36 ? 275 ARG A CZ  1 
ATOM   2054 N  NH1 . ARG A 1 275 ? 44.662 -39.804 8.433   1.00 49.50 ? 275 ARG A NH1 1 
ATOM   2055 N  NH2 . ARG A 1 275 ? 43.273 -39.087 6.767   1.00 60.71 ? 275 ARG A NH2 1 
ATOM   2056 N  N   . GLN A 1 276 ? 47.948 -36.084 2.358   1.00 37.77 ? 276 GLN A N   1 
ATOM   2057 C  CA  . GLN A 1 276 ? 48.268 -34.956 1.508   1.00 39.01 ? 276 GLN A CA  1 
ATOM   2058 C  C   . GLN A 1 276 ? 47.909 -33.656 2.210   1.00 40.77 ? 276 GLN A C   1 
ATOM   2059 O  O   . GLN A 1 276 ? 46.758 -33.489 2.628   1.00 35.68 ? 276 GLN A O   1 
ATOM   2060 C  CB  . GLN A 1 276 ? 47.462 -35.065 0.220   1.00 42.95 ? 276 GLN A CB  1 
ATOM   2061 C  CG  . GLN A 1 276 ? 47.750 -33.975 -0.793  1.00 38.74 ? 276 GLN A CG  1 
ATOM   2062 C  CD  . GLN A 1 276 ? 46.889 -34.142 -2.020  1.00 42.97 ? 276 GLN A CD  1 
ATOM   2063 O  OE1 . GLN A 1 276 ? 46.307 -35.203 -2.231  1.00 44.53 ? 276 GLN A OE1 1 
ATOM   2064 N  NE2 . GLN A 1 276 ? 46.791 -33.097 -2.825  1.00 44.66 ? 276 GLN A NE2 1 
ATOM   2065 N  N   . PRO A 1 277 ? 48.834 -32.710 2.329   1.00 40.30 ? 277 PRO A N   1 
ATOM   2066 C  CA  . PRO A 1 277 ? 48.475 -31.414 2.906   1.00 35.55 ? 277 PRO A CA  1 
ATOM   2067 C  C   . PRO A 1 277 ? 47.413 -30.701 2.080   1.00 41.66 ? 277 PRO A C   1 
ATOM   2068 O  O   . PRO A 1 277 ? 47.269 -30.915 0.873   1.00 36.47 ? 277 PRO A O   1 
ATOM   2069 C  CB  . PRO A 1 277 ? 49.798 -30.639 2.892   1.00 39.84 ? 277 PRO A CB  1 
ATOM   2070 C  CG  . PRO A 1 277 ? 50.841 -31.723 2.995   1.00 48.33 ? 277 PRO A CG  1 
ATOM   2071 C  CD  . PRO A 1 277 ? 50.288 -32.803 2.086   1.00 44.01 ? 277 PRO A CD  1 
ATOM   2072 N  N   . VAL A 1 278 ? 46.672 -29.839 2.760   1.00 39.50 ? 278 VAL A N   1 
ATOM   2073 C  CA  . VAL A 1 278 ? 45.698 -28.957 2.127   1.00 36.89 ? 278 VAL A CA  1 
ATOM   2074 C  C   . VAL A 1 278 ? 46.402 -27.637 1.808   1.00 36.02 ? 278 VAL A C   1 
ATOM   2075 O  O   . VAL A 1 278 ? 46.919 -26.964 2.706   1.00 34.90 ? 278 VAL A O   1 
ATOM   2076 C  CB  . VAL A 1 278 ? 44.494 -28.735 3.054   1.00 37.06 ? 278 VAL A CB  1 
ATOM   2077 C  CG1 . VAL A 1 278 ? 43.520 -27.748 2.416   1.00 37.70 ? 278 VAL A CG1 1 
ATOM   2078 C  CG2 . VAL A 1 278 ? 43.819 -30.060 3.355   1.00 37.90 ? 278 VAL A CG2 1 
ATOM   2079 N  N   . GLU A 1 279 ? 46.432 -27.263 0.533   1.00 35.73 ? 279 GLU A N   1 
ATOM   2080 C  CA  . GLU A 1 279 ? 46.985 -25.967 0.161   1.00 34.71 ? 279 GLU A CA  1 
ATOM   2081 C  C   . GLU A 1 279 ? 46.209 -24.844 0.849   1.00 35.71 ? 279 GLU A C   1 
ATOM   2082 O  O   . GLU A 1 279 ? 44.978 -24.782 0.740   1.00 35.83 ? 279 GLU A O   1 
ATOM   2083 C  CB  . GLU A 1 279 ? 46.930 -25.798 -1.356  1.00 39.49 ? 279 GLU A CB  1 
ATOM   2084 C  CG  . GLU A 1 279 ? 47.949 -26.621 -2.085  1.00 46.25 ? 279 GLU A CG  1 
ATOM   2085 C  CD  . GLU A 1 279 ? 49.140 -25.784 -2.485  1.00 53.14 ? 279 GLU A CD  1 
ATOM   2086 O  OE1 . GLU A 1 279 ? 48.928 -24.690 -3.061  1.00 57.61 ? 279 GLU A OE1 1 
ATOM   2087 O  OE2 . GLU A 1 279 ? 50.286 -26.233 -2.243  1.00 56.82 ? 279 GLU A OE2 1 
ATOM   2088 N  N   . ASP A 1 280 ? 46.957 -23.960 1.525   1.00 32.76 ? 280 ASP A N   1 
ATOM   2089 C  CA  . ASP A 1 280 ? 46.513 -22.955 2.494   1.00 33.37 ? 280 ASP A CA  1 
ATOM   2090 C  C   . ASP A 1 280 ? 47.697 -22.094 2.945   1.00 31.69 ? 280 ASP A C   1 
ATOM   2091 O  O   . ASP A 1 280 ? 48.831 -22.240 2.452   1.00 32.84 ? 280 ASP A O   1 
ATOM   2092 C  CB  . ASP A 1 280 ? 45.852 -23.660 3.689   1.00 34.54 ? 280 ASP A CB  1 
ATOM   2093 C  CG  . ASP A 1 280 ? 44.850 -22.790 4.449   1.00 37.22 ? 280 ASP A CG  1 
ATOM   2094 O  OD1 . ASP A 1 280 ? 44.867 -21.522 4.338   1.00 34.98 ? 280 ASP A OD1 1 
ATOM   2095 O  OD2 . ASP A 1 280 ? 44.090 -23.430 5.225   1.00 33.77 ? 280 ASP A OD2 1 
ATOM   2096 N  N   . ASP A 1 281 ? 47.480 -21.202 3.911   1.00 26.25 ? 281 ASP A N   1 
ATOM   2097 C  CA  . ASP A 1 281 ? 48.466 -20.187 4.239   1.00 27.00 ? 281 ASP A CA  1 
ATOM   2098 C  C   . ASP A 1 281 ? 49.755 -20.746 4.849   1.00 29.65 ? 281 ASP A C   1 
ATOM   2099 O  O   . ASP A 1 281 ? 50.750 -20.020 4.908   1.00 29.21 ? 281 ASP A O   1 
ATOM   2100 C  CB  . ASP A 1 281 ? 47.912 -19.186 5.235   1.00 30.50 ? 281 ASP A CB  1 
ATOM   2101 C  CG  . ASP A 1 281 ? 47.033 -18.132 4.581   1.00 35.87 ? 281 ASP A CG  1 
ATOM   2102 O  OD1 . ASP A 1 281 ? 47.328 -17.715 3.431   1.00 34.65 ? 281 ASP A OD1 1 
ATOM   2103 O  OD2 . ASP A 1 281 ? 46.048 -17.730 5.243   1.00 39.59 ? 281 ASP A OD2 1 
ATOM   2104 N  N   . GLN A 1 282 ? 49.744 -21.973 5.353   1.00 30.66 ? 282 GLN A N   1 
ATOM   2105 C  CA  . GLN A 1 282 ? 50.965 -22.536 5.942   1.00 28.72 ? 282 GLN A CA  1 
ATOM   2106 C  C   . GLN A 1 282 ? 51.964 -22.987 4.876   1.00 36.96 ? 282 GLN A C   1 
ATOM   2107 O  O   . GLN A 1 282 ? 53.156 -23.184 5.188   1.00 36.55 ? 282 GLN A O   1 
ATOM   2108 C  CB  . GLN A 1 282 ? 50.571 -23.719 6.829   1.00 31.23 ? 282 GLN A CB  1 
ATOM   2109 C  CG  . GLN A 1 282 ? 50.542 -25.035 6.069   1.00 34.58 ? 282 GLN A CG  1 
ATOM   2110 C  CD  . GLN A 1 282 ? 49.290 -25.299 5.232   1.00 36.45 ? 282 GLN A CD  1 
ATOM   2111 O  OE1 . GLN A 1 282 ? 48.401 -24.442 5.091   1.00 35.66 ? 282 GLN A OE1 1 
ATOM   2112 N  NE2 . GLN A 1 282 ? 49.224 -26.487 4.656   1.00 35.80 ? 282 GLN A NE2 1 
ATOM   2113 N  N   . VAL A 1 283 ? 51.509 -23.140 3.631   1.00 32.32 ? 283 VAL A N   1 
ATOM   2114 C  CA  . VAL A 1 283 ? 52.371 -23.698 2.582   1.00 32.56 ? 283 VAL A CA  1 
ATOM   2115 C  C   . VAL A 1 283 ? 53.601 -22.845 2.287   1.00 34.77 ? 283 VAL A C   1 
ATOM   2116 O  O   . VAL A 1 283 ? 54.699 -23.410 2.175   1.00 36.71 ? 283 VAL A O   1 
ATOM   2117 C  CB  . VAL A 1 283 ? 51.540 -23.984 1.320   1.00 36.55 ? 283 VAL A CB  1 
ATOM   2118 C  CG1 . VAL A 1 283 ? 52.461 -24.154 0.119   1.00 43.13 ? 283 VAL A CG1 1 
ATOM   2119 C  CG2 . VAL A 1 283 ? 50.701 -25.180 1.526   1.00 33.79 ? 283 VAL A CG2 1 
ATOM   2120 N  N   . PRO A 1 284 ? 53.500 -21.517 2.102   1.00 32.10 ? 284 PRO A N   1 
ATOM   2121 C  CA  . PRO A 1 284 ? 54.729 -20.724 1.886   1.00 33.25 ? 284 PRO A CA  1 
ATOM   2122 C  C   . PRO A 1 284 ? 55.726 -20.825 3.029   1.00 35.56 ? 284 PRO A C   1 
ATOM   2123 O  O   . PRO A 1 284 ? 56.955 -20.926 2.804   1.00 37.81 ? 284 PRO A O   1 
ATOM   2124 C  CB  . PRO A 1 284 ? 54.200 -19.281 1.723   1.00 34.98 ? 284 PRO A CB  1 
ATOM   2125 C  CG  . PRO A 1 284 ? 52.761 -19.437 1.343   1.00 38.91 ? 284 PRO A CG  1 
ATOM   2126 C  CD  . PRO A 1 284 ? 52.279 -20.681 2.047   1.00 34.00 ? 284 PRO A CD  1 
ATOM   2127 N  N   . PHE A 1 285 ? 55.219 -20.782 4.272   1.00 30.80 ? 285 PHE A N   1 
ATOM   2128 C  CA  . PHE A 1 285 ? 56.087 -20.894 5.439   1.00 35.43 ? 285 PHE A CA  1 
ATOM   2129 C  C   . PHE A 1 285 ? 56.734 -22.273 5.494   1.00 31.43 ? 285 PHE A C   1 
ATOM   2130 O  O   . PHE A 1 285 ? 57.949 -22.392 5.664   1.00 33.81 ? 285 PHE A O   1 
ATOM   2131 C  CB  . PHE A 1 285 ? 55.266 -20.621 6.705   1.00 36.05 ? 285 PHE A CB  1 
ATOM   2132 C  CG  . PHE A 1 285 ? 54.823 -19.197 6.821   1.00 34.75 ? 285 PHE A CG  1 
ATOM   2133 C  CD1 . PHE A 1 285 ? 55.674 -18.239 7.370   1.00 38.23 ? 285 PHE A CD1 1 
ATOM   2134 C  CD2 . PHE A 1 285 ? 53.585 -18.801 6.346   1.00 37.12 ? 285 PHE A CD2 1 
ATOM   2135 C  CE1 . PHE A 1 285 ? 55.288 -16.908 7.478   1.00 40.92 ? 285 PHE A CE1 1 
ATOM   2136 C  CE2 . PHE A 1 285 ? 53.199 -17.456 6.460   1.00 40.79 ? 285 PHE A CE2 1 
ATOM   2137 C  CZ  . PHE A 1 285 ? 54.067 -16.522 7.013   1.00 36.87 ? 285 PHE A CZ  1 
ATOM   2138 N  N   . SER A 1 286 ? 55.927 -23.320 5.346   1.00 27.64 ? 286 SER A N   1 
ATOM   2139 C  CA  . SER A 1 286 ? 56.458 -24.688 5.402   1.00 31.98 ? 286 SER A CA  1 
ATOM   2140 C  C   . SER A 1 286 ? 57.520 -24.907 4.330   1.00 32.44 ? 286 SER A C   1 
ATOM   2141 O  O   . SER A 1 286 ? 58.565 -25.541 4.582   1.00 31.62 ? 286 SER A O   1 
ATOM   2142 C  CB  . SER A 1 286 ? 55.304 -25.676 5.253   1.00 38.08 ? 286 SER A CB  1 
ATOM   2143 O  OG  . SER A 1 286 ? 55.764 -26.988 5.430   1.00 37.84 ? 286 SER A OG  1 
ATOM   2144 N  N   . GLY A 1 287 ? 57.279 -24.388 3.129   1.00 29.34 ? 287 GLY A N   1 
ATOM   2145 C  CA  . GLY A 1 287 ? 58.258 -24.509 2.061   1.00 34.83 ? 287 GLY A CA  1 
ATOM   2146 C  C   . GLY A 1 287 ? 59.572 -23.810 2.348   1.00 36.45 ? 287 GLY A C   1 
ATOM   2147 O  O   . GLY A 1 287 ? 60.617 -24.190 1.797   1.00 38.53 ? 287 GLY A O   1 
ATOM   2148 N  N   . LEU A 1 288 ? 59.558 -22.771 3.181   1.00 33.97 ? 288 LEU A N   1 
ATOM   2149 C  CA  . LEU A 1 288 ? 60.828 -22.165 3.555   1.00 33.61 ? 288 LEU A CA  1 
ATOM   2150 C  C   . LEU A 1 288 ? 61.369 -22.657 4.904   1.00 36.53 ? 288 LEU A C   1 
ATOM   2151 O  O   . LEU A 1 288 ? 62.241 -21.997 5.483   1.00 41.61 ? 288 LEU A O   1 
ATOM   2152 C  CB  . LEU A 1 288 ? 60.705 -20.644 3.566   1.00 37.04 ? 288 LEU A CB  1 
ATOM   2153 C  CG  . LEU A 1 288 ? 60.363 -19.951 2.268   1.00 39.04 ? 288 LEU A CG  1 
ATOM   2154 C  CD1 . LEU A 1 288 ? 60.796 -18.517 2.404   1.00 37.59 ? 288 LEU A CD1 1 
ATOM   2155 C  CD2 . LEU A 1 288 ? 61.044 -20.590 1.056   1.00 37.41 ? 288 LEU A CD2 1 
ATOM   2156 N  N   . GLY A 1 289 ? 60.887 -23.797 5.400   1.00 34.38 ? 289 GLY A N   1 
ATOM   2157 C  CA  . GLY A 1 289 ? 61.463 -24.459 6.564   1.00 32.30 ? 289 GLY A CA  1 
ATOM   2158 C  C   . GLY A 1 289 ? 60.823 -24.163 7.906   1.00 36.89 ? 289 GLY A C   1 
ATOM   2159 O  O   . GLY A 1 289 ? 61.419 -24.498 8.932   1.00 35.60 ? 289 GLY A O   1 
ATOM   2160 N  N   . VAL A 1 290 ? 59.622 -23.559 7.944   1.00 32.34 ? 290 VAL A N   1 
ATOM   2161 C  CA  . VAL A 1 290 ? 58.948 -23.308 9.222   1.00 33.88 ? 290 VAL A CA  1 
ATOM   2162 C  C   . VAL A 1 290 ? 58.221 -24.573 9.662   1.00 30.22 ? 290 VAL A C   1 
ATOM   2163 O  O   . VAL A 1 290 ? 57.631 -25.270 8.842   1.00 33.68 ? 290 VAL A O   1 
ATOM   2164 C  CB  . VAL A 1 290 ? 57.971 -22.113 9.099   1.00 27.07 ? 290 VAL A CB  1 
ATOM   2165 C  CG1 . VAL A 1 290 ? 57.359 -21.808 10.476  1.00 30.60 ? 290 VAL A CG1 1 
ATOM   2166 C  CG2 . VAL A 1 290 ? 58.687 -20.915 8.620   1.00 32.94 ? 290 VAL A CG2 1 
ATOM   2167 N  N   . LYS A 1 291 ? 58.280 -24.898 10.958  1.00 28.61 ? 291 LYS A N   1 
ATOM   2168 C  CA  . LYS A 1 291 ? 57.430 -25.950 11.513  1.00 29.60 ? 291 LYS A CA  1 
ATOM   2169 C  C   . LYS A 1 291 ? 55.984 -25.455 11.562  1.00 31.28 ? 291 LYS A C   1 
ATOM   2170 O  O   . LYS A 1 291 ? 55.711 -24.462 12.242  1.00 35.20 ? 291 LYS A O   1 
ATOM   2171 C  CB  . LYS A 1 291 ? 57.891 -26.329 12.934  1.00 27.57 ? 291 LYS A CB  1 
ATOM   2172 C  CG  . LYS A 1 291 ? 59.270 -26.994 12.977  1.00 37.42 ? 291 LYS A CG  1 
ATOM   2173 C  CD  . LYS A 1 291 ? 59.657 -27.533 14.381  1.00 38.62 ? 291 LYS A CD  1 
ATOM   2174 C  CE  . LYS A 1 291 ? 58.505 -28.258 15.087  1.00 41.50 ? 291 LYS A CE  1 
ATOM   2175 N  NZ  . LYS A 1 291 ? 58.897 -28.522 16.503  1.00 56.08 ? 291 LYS A NZ  1 
ATOM   2176 N  N   . VAL A 1 292 ? 55.059 -26.160 10.886  1.00 30.44 ? 292 VAL A N   1 
ATOM   2177 C  CA  . VAL A 1 292 ? 53.662 -25.740 10.824  1.00 33.40 ? 292 VAL A CA  1 
ATOM   2178 C  C   . VAL A 1 292 ? 52.768 -26.887 11.271  1.00 36.29 ? 292 VAL A C   1 
ATOM   2179 O  O   . VAL A 1 292 ? 53.033 -28.071 11.008  1.00 31.61 ? 292 VAL A O   1 
ATOM   2180 C  CB  . VAL A 1 292 ? 53.253 -25.222 9.409   1.00 27.44 ? 292 VAL A CB  1 
ATOM   2181 C  CG1 . VAL A 1 292 ? 54.207 -24.164 8.958   1.00 29.35 ? 292 VAL A CG1 1 
ATOM   2182 C  CG2 . VAL A 1 292 ? 53.129 -26.365 8.376   1.00 35.10 ? 292 VAL A CG2 1 
ATOM   2183 N  N   . LEU A 1 293 ? 51.724 -26.516 12.008  1.00 30.69 ? 293 LEU A N   1 
ATOM   2184 C  CA  . LEU A 1 293 ? 50.646 -27.382 12.441  1.00 27.85 ? 293 LEU A CA  1 
ATOM   2185 C  C   . LEU A 1 293 ? 49.383 -26.785 11.848  1.00 32.87 ? 293 LEU A C   1 
ATOM   2186 O  O   . LEU A 1 293 ? 49.078 -25.618 12.130  1.00 34.36 ? 293 LEU A O   1 
ATOM   2187 C  CB  . LEU A 1 293 ? 50.580 -27.395 13.978  1.00 30.49 ? 293 LEU A CB  1 
ATOM   2188 C  CG  . LEU A 1 293 ? 49.480 -28.191 14.659  1.00 28.43 ? 293 LEU A CG  1 
ATOM   2189 C  CD1 . LEU A 1 293 ? 49.616 -29.673 14.307  1.00 33.65 ? 293 LEU A CD1 1 
ATOM   2190 C  CD2 . LEU A 1 293 ? 49.523 -27.979 16.141  1.00 30.96 ? 293 LEU A CD2 1 
ATOM   2191 N  N   . HIS A 1 294 ? 48.674 -27.560 11.039  1.00 32.43 ? 294 HIS A N   1 
ATOM   2192 C  CA  . HIS A 1 294 ? 47.540 -27.079 10.236  1.00 33.74 ? 294 HIS A CA  1 
ATOM   2193 C  C   . HIS A 1 294 ? 46.250 -27.630 10.810  1.00 31.19 ? 294 HIS A C   1 
ATOM   2194 O  O   . HIS A 1 294 ? 45.910 -28.786 10.581  1.00 33.41 ? 294 HIS A O   1 
ATOM   2195 C  CB  . HIS A 1 294 ? 47.671 -27.492 8.775   1.00 36.26 ? 294 HIS A CB  1 
ATOM   2196 C  CG  . HIS A 1 294 ? 46.741 -26.745 7.855   1.00 36.03 ? 294 HIS A CG  1 
ATOM   2197 N  ND1 . HIS A 1 294 ? 46.595 -27.058 6.520   1.00 34.87 ? 294 HIS A ND1 1 
ATOM   2198 C  CD2 . HIS A 1 294 ? 45.928 -25.686 8.086   1.00 34.10 ? 294 HIS A CD2 1 
ATOM   2199 C  CE1 . HIS A 1 294 ? 45.724 -26.231 5.968   1.00 37.32 ? 294 HIS A CE1 1 
ATOM   2200 N  NE2 . HIS A 1 294 ? 45.302 -25.387 6.895   1.00 36.41 ? 294 HIS A NE2 1 
ATOM   2201 N  N   . VAL A 1 295 ? 45.515 -26.807 11.550  1.00 30.36 ? 295 VAL A N   1 
ATOM   2202 C  CA  . VAL A 1 295 ? 44.281 -27.229 12.193  1.00 33.38 ? 295 VAL A CA  1 
ATOM   2203 C  C   . VAL A 1 295 ? 43.135 -26.789 11.292  1.00 36.67 ? 295 VAL A C   1 
ATOM   2204 O  O   . VAL A 1 295 ? 42.685 -25.639 11.353  1.00 31.69 ? 295 VAL A O   1 
ATOM   2205 C  CB  . VAL A 1 295 ? 44.168 -26.643 13.600  1.00 35.30 ? 295 VAL A CB  1 
ATOM   2206 C  CG1 . VAL A 1 295 ? 42.961 -27.225 14.301  1.00 36.33 ? 295 VAL A CG1 1 
ATOM   2207 C  CG2 . VAL A 1 295 ? 45.485 -26.900 14.385  1.00 31.16 ? 295 VAL A CG2 1 
ATOM   2208 N  N   . ILE A 1 296 ? 42.660 -27.700 10.455  1.00 38.21 ? 296 ILE A N   1 
ATOM   2209 C  CA  . ILE A 1 296 ? 41.617 -27.401 9.486   1.00 38.12 ? 296 ILE A CA  1 
ATOM   2210 C  C   . ILE A 1 296 ? 40.628 -28.558 9.475   1.00 39.01 ? 296 ILE A C   1 
ATOM   2211 O  O   . ILE A 1 296 ? 41.022 -29.728 9.492   1.00 40.51 ? 296 ILE A O   1 
ATOM   2212 C  CB  . ILE A 1 296 ? 42.220 -27.138 8.090   1.00 34.89 ? 296 ILE A CB  1 
ATOM   2213 C  CG1 . ILE A 1 296 ? 41.123 -26.943 7.038   1.00 34.54 ? 296 ILE A CG1 1 
ATOM   2214 C  CG2 . ILE A 1 296 ? 43.150 -28.266 7.657   1.00 33.99 ? 296 ILE A CG2 1 
ATOM   2215 C  CD1 . ILE A 1 296 ? 41.683 -26.334 5.751   1.00 33.26 ? 296 ILE A CD1 1 
ATOM   2216 N  N   . ASP A 1 297 ? 39.335 -28.234 9.464   1.00 38.39 ? 297 ASP A N   1 
ATOM   2217 C  CA  . ASP A 1 297 ? 38.278 -29.240 9.434   1.00 39.03 ? 297 ASP A CA  1 
ATOM   2218 C  C   . ASP A 1 297 ? 38.111 -29.765 8.015   1.00 42.59 ? 297 ASP A C   1 
ATOM   2219 O  O   . ASP A 1 297 ? 37.779 -29.007 7.105   1.00 40.51 ? 297 ASP A O   1 
ATOM   2220 C  CB  . ASP A 1 297 ? 36.956 -28.652 9.935   1.00 39.77 ? 297 ASP A CB  1 
ATOM   2221 C  CG  . ASP A 1 297 ? 35.830 -29.696 10.037  1.00 42.05 ? 297 ASP A CG  1 
ATOM   2222 O  OD1 . ASP A 1 297 ? 36.046 -30.881 9.702   1.00 48.18 ? 297 ASP A OD1 1 
ATOM   2223 O  OD2 . ASP A 1 297 ? 34.706 -29.322 10.455  1.00 44.41 ? 297 ASP A OD2 1 
ATOM   2224 N  N   . ALA A 1 298 ? 38.300 -31.064 7.831   1.00 47.35 ? 298 ALA A N   1 
ATOM   2225 C  CA  . ALA A 1 298 ? 38.192 -31.648 6.504   1.00 51.42 ? 298 ALA A CA  1 
ATOM   2226 C  C   . ALA A 1 298 ? 38.124 -33.150 6.669   1.00 56.97 ? 298 ALA A C   1 
ATOM   2227 O  O   . ALA A 1 298 ? 38.831 -33.707 7.512   1.00 57.53 ? 298 ALA A O   1 
ATOM   2228 C  CB  . ALA A 1 298 ? 39.384 -31.255 5.619   1.00 45.08 ? 298 ALA A CB  1 
ATOM   2229 N  N   . ASP A 1 299 ? 37.252 -33.792 5.903   1.00 61.05 ? 299 ASP A N   1 
ATOM   2230 C  CA  . ASP A 1 299 ? 37.151 -35.237 5.987   1.00 64.04 ? 299 ASP A CA  1 
ATOM   2231 C  C   . ASP A 1 299 ? 38.536 -35.845 5.761   1.00 63.68 ? 299 ASP A C   1 
ATOM   2232 O  O   . ASP A 1 299 ? 39.234 -35.459 4.811   1.00 63.30 ? 299 ASP A O   1 
ATOM   2233 C  CB  . ASP A 1 299 ? 36.136 -35.779 4.978   1.00 64.67 ? 299 ASP A CB  1 
ATOM   2234 C  CG  . ASP A 1 299 ? 36.016 -37.298 5.023   1.00 67.11 ? 299 ASP A CG  1 
ATOM   2235 O  OD1 . ASP A 1 299 ? 36.977 -37.983 4.611   1.00 66.38 ? 299 ASP A OD1 1 
ATOM   2236 O  OD2 . ASP A 1 299 ? 34.979 -37.804 5.517   1.00 64.66 ? 299 ASP A OD2 1 
ATOM   2237 N  N   . PRO A 1 300 ? 38.992 -36.739 6.640   1.00 62.59 ? 300 PRO A N   1 
ATOM   2238 C  CA  . PRO A 1 300 ? 40.384 -37.200 6.548   1.00 63.37 ? 300 PRO A CA  1 
ATOM   2239 C  C   . PRO A 1 300 ? 40.680 -37.989 5.276   1.00 68.00 ? 300 PRO A C   1 
ATOM   2240 O  O   . PRO A 1 300 ? 41.823 -37.961 4.790   1.00 65.35 ? 300 PRO A O   1 
ATOM   2241 C  CB  . PRO A 1 300 ? 40.537 -38.055 7.811   1.00 66.13 ? 300 PRO A CB  1 
ATOM   2242 C  CG  . PRO A 1 300 ? 39.139 -38.571 8.081   1.00 64.60 ? 300 PRO A CG  1 
ATOM   2243 C  CD  . PRO A 1 300 ? 38.209 -37.477 7.647   1.00 64.09 ? 300 PRO A CD  1 
ATOM   2244 N  N   . THR A 1 301 ? 39.669 -38.657 4.709   1.00 69.16 ? 301 THR A N   1 
ATOM   2245 C  CA  . THR A 1 301 ? 39.792 -39.496 3.519   1.00 71.59 ? 301 THR A CA  1 
ATOM   2246 C  C   . THR A 1 301 ? 39.718 -38.788 2.167   1.00 70.87 ? 301 THR A C   1 
ATOM   2247 O  O   . THR A 1 301 ? 40.708 -38.706 1.424   1.00 68.78 ? 301 THR A O   1 
ATOM   2248 C  CB  . THR A 1 301 ? 38.660 -40.522 3.501   1.00 70.56 ? 301 THR A CB  1 
ATOM   2249 O  OG1 . THR A 1 301 ? 38.560 -41.147 4.787   1.00 74.27 ? 301 THR A OG1 1 
ATOM   2250 C  CG2 . THR A 1 301 ? 38.922 -41.568 2.426   1.00 68.48 ? 301 THR A CG2 1 
ATOM   2251 N  N   . THR A 1 302 ? 38.515 -38.298 1.846   1.00 71.35 ? 302 THR A N   1 
ATOM   2252 C  CA  . THR A 1 302 ? 38.262 -37.570 0.605   1.00 66.53 ? 302 THR A CA  1 
ATOM   2253 C  C   . THR A 1 302 ? 39.030 -36.252 0.605   1.00 69.72 ? 302 THR A C   1 
ATOM   2254 O  O   . THR A 1 302 ? 39.527 -35.805 -0.437  1.00 68.10 ? 302 THR A O   1 
ATOM   2255 C  CB  . THR A 1 302 ? 36.769 -37.297 0.494   1.00 65.39 ? 302 THR A CB  1 
ATOM   2256 O  OG1 . THR A 1 302 ? 36.467 -36.132 1.262   1.00 65.72 ? 302 THR A OG1 1 
ATOM   2257 C  CG2 . THR A 1 302 ? 35.971 -38.467 1.052   1.00 67.16 ? 302 THR A CG2 1 
ATOM   2258 N  N   . GLY A 1 303 ? 39.134 -35.611 1.759   1.00 64.82 ? 303 GLY A N   1 
ATOM   2259 C  CA  . GLY A 1 303 ? 39.681 -34.279 1.817   1.00 61.57 ? 303 GLY A CA  1 
ATOM   2260 C  C   . GLY A 1 303 ? 38.671 -33.172 1.614   1.00 62.44 ? 303 GLY A C   1 
ATOM   2261 O  O   . GLY A 1 303 ? 39.077 -32.026 1.383   1.00 59.91 ? 303 GLY A O   1 
ATOM   2262 N  N   . GLU A 1 304 ? 37.374 -33.468 1.690   1.00 61.61 ? 304 GLU A N   1 
ATOM   2263 C  CA  . GLU A 1 304 ? 36.357 -32.462 1.412   1.00 62.24 ? 304 GLU A CA  1 
ATOM   2264 C  C   . GLU A 1 304 ? 35.998 -31.674 2.662   1.00 56.18 ? 304 GLU A C   1 
ATOM   2265 O  O   . GLU A 1 304 ? 35.931 -32.222 3.769   1.00 54.61 ? 304 GLU A O   1 
ATOM   2266 C  CB  . GLU A 1 304 ? 35.097 -33.078 0.794   1.00 66.72 ? 304 GLU A CB  1 
ATOM   2267 C  CG  . GLU A 1 304 ? 35.350 -33.879 -0.489  1.00 72.47 ? 304 GLU A CG  1 
ATOM   2268 C  CD  . GLU A 1 304 ? 34.197 -34.806 -0.859  1.00 78.84 ? 304 GLU A CD  1 
ATOM   2269 O  OE1 . GLU A 1 304 ? 33.335 -35.073 0.011   1.00 79.95 ? 304 GLU A OE1 1 
ATOM   2270 O  OE2 . GLU A 1 304 ? 34.152 -35.253 -2.030  1.00 77.81 ? 304 GLU A OE2 1 
ATOM   2271 N  N   . PHE A 1 305 ? 35.754 -30.380 2.455   1.00 48.63 ? 305 PHE A N   1 
ATOM   2272 C  CA  . PHE A 1 305 ? 35.570 -29.395 3.507   1.00 47.17 ? 305 PHE A CA  1 
ATOM   2273 C  C   . PHE A 1 305 ? 34.155 -29.493 4.071   1.00 47.59 ? 305 PHE A C   1 
ATOM   2274 O  O   . PHE A 1 305 ? 33.333 -30.267 3.579   1.00 46.79 ? 305 PHE A O   1 
ATOM   2275 C  CB  . PHE A 1 305 ? 35.855 -28.008 2.931   1.00 44.30 ? 305 PHE A CB  1 
ATOM   2276 C  CG  . PHE A 1 305 ? 37.274 -27.820 2.465   1.00 44.80 ? 305 PHE A CG  1 
ATOM   2277 C  CD1 . PHE A 1 305 ? 38.346 -28.186 3.269   1.00 44.06 ? 305 PHE A CD1 1 
ATOM   2278 C  CD2 . PHE A 1 305 ? 37.536 -27.279 1.208   1.00 46.53 ? 305 PHE A CD2 1 
ATOM   2279 C  CE1 . PHE A 1 305 ? 39.659 -27.994 2.831   1.00 39.90 ? 305 PHE A CE1 1 
ATOM   2280 C  CE2 . PHE A 1 305 ? 38.836 -27.085 0.770   1.00 46.64 ? 305 PHE A CE2 1 
ATOM   2281 C  CZ  . PHE A 1 305 ? 39.904 -27.454 1.592   1.00 41.47 ? 305 PHE A CZ  1 
ATOM   2282 N  N   . PRO A 1 306 ? 33.857 -28.765 5.149   1.00 45.13 ? 306 PRO A N   1 
ATOM   2283 C  CA  . PRO A 1 306 ? 32.479 -28.730 5.663   1.00 51.03 ? 306 PRO A CA  1 
ATOM   2284 C  C   . PRO A 1 306 ? 31.485 -28.342 4.577   1.00 45.61 ? 306 PRO A C   1 
ATOM   2285 O  O   . PRO A 1 306 ? 31.828 -27.652 3.614   1.00 47.83 ? 306 PRO A O   1 
ATOM   2286 C  CB  . PRO A 1 306 ? 32.544 -27.672 6.772   1.00 44.01 ? 306 PRO A CB  1 
ATOM   2287 C  CG  . PRO A 1 306 ? 33.948 -27.779 7.283   1.00 43.89 ? 306 PRO A CG  1 
ATOM   2288 C  CD  . PRO A 1 306 ? 34.815 -28.178 6.108   1.00 45.96 ? 306 PRO A CD  1 
ATOM   2289 N  N   . SER A 1 307 ? 30.237 -28.795 4.744   1.00 50.89 ? 307 SER A N   1 
ATOM   2290 C  CA  . SER A 1 307 ? 29.252 -28.667 3.670   1.00 47.84 ? 307 SER A CA  1 
ATOM   2291 C  C   . SER A 1 307 ? 28.994 -27.206 3.314   1.00 47.89 ? 307 SER A C   1 
ATOM   2292 O  O   . SER A 1 307 ? 28.793 -26.873 2.139   1.00 48.15 ? 307 SER A O   1 
ATOM   2293 C  CB  . SER A 1 307 ? 27.951 -29.361 4.070   1.00 53.03 ? 307 SER A CB  1 
ATOM   2294 O  OG  . SER A 1 307 ? 27.506 -28.873 5.323   1.00 54.67 ? 307 SER A OG  1 
ATOM   2295 N  N   . VAL A 1 308 ? 29.016 -26.314 4.306   1.00 45.39 ? 308 VAL A N   1 
ATOM   2296 C  CA  . VAL A 1 308 ? 28.775 -24.900 4.037   1.00 46.93 ? 308 VAL A CA  1 
ATOM   2297 C  C   . VAL A 1 308 ? 29.924 -24.211 3.317   1.00 50.77 ? 308 VAL A C   1 
ATOM   2298 O  O   . VAL A 1 308 ? 29.786 -23.039 2.948   1.00 50.92 ? 308 VAL A O   1 
ATOM   2299 C  CB  . VAL A 1 308 ? 28.472 -24.154 5.350   1.00 49.05 ? 308 VAL A CB  1 
ATOM   2300 C  CG1 . VAL A 1 308 ? 27.234 -24.730 5.992   1.00 48.66 ? 308 VAL A CG1 1 
ATOM   2301 C  CG2 . VAL A 1 308 ? 29.661 -24.261 6.308   1.00 50.97 ? 308 VAL A CG2 1 
ATOM   2302 N  N   . TRP A 1 309 ? 31.051 -24.900 3.107   1.00 47.47 ? 309 TRP A N   1 
ATOM   2303 C  CA  . TRP A 1 309 ? 32.248 -24.262 2.567   1.00 44.53 ? 309 TRP A CA  1 
ATOM   2304 C  C   . TRP A 1 309 ? 31.943 -23.584 1.235   1.00 40.60 ? 309 TRP A C   1 
ATOM   2305 O  O   . TRP A 1 309 ? 31.487 -24.232 0.286   1.00 43.89 ? 309 TRP A O   1 
ATOM   2306 C  CB  . TRP A 1 309 ? 33.365 -25.300 2.390   1.00 44.95 ? 309 TRP A CB  1 
ATOM   2307 C  CG  . TRP A 1 309 ? 34.622 -24.757 1.789   1.00 39.95 ? 309 TRP A CG  1 
ATOM   2308 C  CD1 . TRP A 1 309 ? 35.545 -23.974 2.410   1.00 41.28 ? 309 TRP A CD1 1 
ATOM   2309 C  CD2 . TRP A 1 309 ? 35.084 -24.921 0.436   1.00 43.08 ? 309 TRP A CD2 1 
ATOM   2310 N  NE1 . TRP A 1 309 ? 36.557 -23.656 1.543   1.00 38.13 ? 309 TRP A NE1 1 
ATOM   2311 C  CE2 . TRP A 1 309 ? 36.297 -24.219 0.324   1.00 41.19 ? 309 TRP A CE2 1 
ATOM   2312 C  CE3 . TRP A 1 309 ? 34.599 -25.604 -0.677  1.00 43.79 ? 309 TRP A CE3 1 
ATOM   2313 C  CZ2 . TRP A 1 309 ? 37.037 -24.187 -0.853  1.00 43.34 ? 309 TRP A CZ2 1 
ATOM   2314 C  CZ3 . TRP A 1 309 ? 35.324 -25.556 -1.851  1.00 49.46 ? 309 TRP A CZ3 1 
ATOM   2315 C  CH2 . TRP A 1 309 ? 36.531 -24.849 -1.931  1.00 40.56 ? 309 TRP A CH2 1 
ATOM   2316 N  N   . HIS A 1 310 ? 32.188 -22.279 1.185   1.00 37.71 ? 310 HIS A N   1 
ATOM   2317 C  CA  . HIS A 1 310 ? 32.109 -21.443 -0.005  1.00 42.87 ? 310 HIS A CA  1 
ATOM   2318 C  C   . HIS A 1 310 ? 30.696 -21.327 -0.563  1.00 44.33 ? 310 HIS A C   1 
ATOM   2319 O  O   . HIS A 1 310 ? 30.528 -21.006 -1.743  1.00 44.18 ? 310 HIS A O   1 
ATOM   2320 C  CB  . HIS A 1 310 ? 33.075 -21.922 -1.090  1.00 39.01 ? 310 HIS A CB  1 
ATOM   2321 C  CG  . HIS A 1 310 ? 34.489 -21.502 -0.835  1.00 39.90 ? 310 HIS A CG  1 
ATOM   2322 N  ND1 . HIS A 1 310 ? 35.414 -21.341 -1.842  1.00 40.73 ? 310 HIS A ND1 1 
ATOM   2323 C  CD2 . HIS A 1 310 ? 35.126 -21.189 0.314   1.00 42.28 ? 310 HIS A CD2 1 
ATOM   2324 C  CE1 . HIS A 1 310 ? 36.563 -20.953 -1.327  1.00 40.87 ? 310 HIS A CE1 1 
ATOM   2325 N  NE2 . HIS A 1 310 ? 36.418 -20.858 -0.018  1.00 39.62 ? 310 HIS A NE2 1 
ATOM   2326 N  N   . THR A 1 311 ? 29.692 -21.583 0.270   1.00 47.62 ? 311 THR A N   1 
ATOM   2327 C  CA  . THR A 1 311 ? 28.282 -21.344 0.004   1.00 44.76 ? 311 THR A CA  1 
ATOM   2328 C  C   . THR A 1 311 ? 27.764 -20.188 0.859   1.00 47.93 ? 311 THR A C   1 
ATOM   2329 O  O   . THR A 1 311 ? 28.418 -19.761 1.816   1.00 45.67 ? 311 THR A O   1 
ATOM   2330 C  CB  . THR A 1 311 ? 27.457 -22.598 0.310   1.00 46.62 ? 311 THR A CB  1 
ATOM   2331 O  OG1 . THR A 1 311 ? 27.260 -22.692 1.728   1.00 48.20 ? 311 THR A OG1 1 
ATOM   2332 C  CG2 . THR A 1 311 ? 28.151 -23.851 -0.211  1.00 45.76 ? 311 THR A CG2 1 
ATOM   2333 N  N   . PRO A 1 312 ? 26.578 -19.659 0.546   1.00 49.21 ? 312 PRO A N   1 
ATOM   2334 C  CA  . PRO A 1 312 ? 25.985 -18.638 1.426   1.00 50.13 ? 312 PRO A CA  1 
ATOM   2335 C  C   . PRO A 1 312 ? 25.604 -19.151 2.817   1.00 53.11 ? 312 PRO A C   1 
ATOM   2336 O  O   . PRO A 1 312 ? 25.482 -18.334 3.738   1.00 50.53 ? 312 PRO A O   1 
ATOM   2337 C  CB  . PRO A 1 312 ? 24.753 -18.170 0.638   1.00 50.27 ? 312 PRO A CB  1 
ATOM   2338 C  CG  . PRO A 1 312 ? 25.086 -18.459 -0.786  1.00 48.11 ? 312 PRO A CG  1 
ATOM   2339 C  CD  . PRO A 1 312 ? 25.892 -19.733 -0.757  1.00 52.15 ? 312 PRO A CD  1 
ATOM   2340 N  N   . ASP A 1 313 ? 25.422 -20.466 3.009   1.00 49.50 ? 313 ASP A N   1 
ATOM   2341 C  CA  . ASP A 1 313 ? 25.117 -21.010 4.332   1.00 47.25 ? 313 ASP A CA  1 
ATOM   2342 C  C   . ASP A 1 313 ? 26.287 -20.953 5.316   1.00 51.69 ? 313 ASP A C   1 
ATOM   2343 O  O   . ASP A 1 313 ? 26.097 -21.311 6.485   1.00 50.11 ? 313 ASP A O   1 
ATOM   2344 C  CB  . ASP A 1 313 ? 24.637 -22.453 4.211   1.00 54.15 ? 313 ASP A CB  1 
ATOM   2345 C  CG  . ASP A 1 313 ? 23.311 -22.547 3.517   1.00 54.56 ? 313 ASP A CG  1 
ATOM   2346 O  OD1 . ASP A 1 313 ? 22.736 -21.479 3.246   1.00 57.69 ? 313 ASP A OD1 1 
ATOM   2347 O  OD2 . ASP A 1 313 ? 22.844 -23.666 3.244   1.00 61.96 ? 313 ASP A OD2 1 
ATOM   2348 N  N   . ASP A 1 314 ? 27.481 -20.535 4.896   1.00 48.69 ? 314 ASP A N   1 
ATOM   2349 C  CA  . ASP A 1 314 ? 28.582 -20.306 5.832   1.00 48.56 ? 314 ASP A CA  1 
ATOM   2350 C  C   . ASP A 1 314 ? 28.392 -18.928 6.468   1.00 46.06 ? 314 ASP A C   1 
ATOM   2351 O  O   . ASP A 1 314 ? 29.101 -17.961 6.186   1.00 41.80 ? 314 ASP A O   1 
ATOM   2352 C  CB  . ASP A 1 314 ? 29.931 -20.435 5.133   1.00 43.35 ? 314 ASP A CB  1 
ATOM   2353 C  CG  . ASP A 1 314 ? 31.105 -20.246 6.092   1.00 41.91 ? 314 ASP A CG  1 
ATOM   2354 O  OD1 . ASP A 1 314 ? 30.887 -20.220 7.331   1.00 40.15 ? 314 ASP A OD1 1 
ATOM   2355 O  OD2 . ASP A 1 314 ? 32.248 -20.107 5.613   1.00 43.48 ? 314 ASP A OD2 1 
ATOM   2356 N  N   . ASP A 1 315 ? 27.399 -18.853 7.353   1.00 50.08 ? 315 ASP A N   1 
ATOM   2357 C  CA  . ASP A 1 315 ? 27.037 -17.607 8.008   1.00 49.41 ? 315 ASP A CA  1 
ATOM   2358 C  C   . ASP A 1 315 ? 26.898 -17.856 9.500   1.00 51.40 ? 315 ASP A C   1 
ATOM   2359 O  O   . ASP A 1 315 ? 27.107 -18.969 9.990   1.00 51.55 ? 315 ASP A O   1 
ATOM   2360 C  CB  . ASP A 1 315 ? 25.740 -17.032 7.416   1.00 50.32 ? 315 ASP A CB  1 
ATOM   2361 C  CG  . ASP A 1 315 ? 24.594 -18.024 7.450   1.00 53.18 ? 315 ASP A CG  1 
ATOM   2362 O  OD1 . ASP A 1 315 ? 24.585 -18.933 8.315   1.00 49.59 ? 315 ASP A OD1 1 
ATOM   2363 O  OD2 . ASP A 1 315 ? 23.701 -17.901 6.590   1.00 58.93 ? 315 ASP A OD2 1 
ATOM   2364 N  N   . GLU A 1 316 ? 26.505 -16.811 10.223  1.00 49.17 ? 316 GLU A N   1 
ATOM   2365 C  CA  . GLU A 1 316 ? 26.425 -16.920 11.671  1.00 50.88 ? 316 GLU A CA  1 
ATOM   2366 C  C   . GLU A 1 316 ? 25.395 -17.946 12.108  1.00 51.26 ? 316 GLU A C   1 
ATOM   2367 O  O   . GLU A 1 316 ? 25.584 -18.615 13.127  1.00 49.30 ? 316 GLU A O   1 
ATOM   2368 C  CB  . GLU A 1 316 ? 26.115 -15.559 12.270  1.00 48.81 ? 316 GLU A CB  1 
ATOM   2369 C  CG  . GLU A 1 316 ? 26.344 -15.467 13.766  1.00 49.84 ? 316 GLU A CG  1 
ATOM   2370 C  CD  . GLU A 1 316 ? 25.824 -14.166 14.305  1.00 52.27 ? 316 GLU A CD  1 
ATOM   2371 O  OE1 . GLU A 1 316 ? 25.225 -13.423 13.497  1.00 57.20 ? 316 GLU A OE1 1 
ATOM   2372 O  OE2 . GLU A 1 316 ? 26.002 -13.885 15.507  1.00 58.03 ? 316 GLU A OE2 1 
ATOM   2373 N  N   . ASN A 1 317 ? 24.313 -18.101 11.347  1.00 52.51 ? 317 ASN A N   1 
ATOM   2374 C  CA  . ASN A 1 317 ? 23.251 -19.015 11.748  1.00 56.53 ? 317 ASN A CA  1 
ATOM   2375 C  C   . ASN A 1 317 ? 23.692 -20.468 11.700  1.00 54.89 ? 317 ASN A C   1 
ATOM   2376 O  O   . ASN A 1 317 ? 23.102 -21.314 12.384  1.00 51.78 ? 317 ASN A O   1 
ATOM   2377 C  CB  . ASN A 1 317 ? 22.027 -18.814 10.856  1.00 54.85 ? 317 ASN A CB  1 
ATOM   2378 C  CG  . ASN A 1 317 ? 21.057 -17.817 11.437  1.00 62.55 ? 317 ASN A CG  1 
ATOM   2379 O  OD1 . ASN A 1 317 ? 20.823 -16.753 10.856  1.00 65.92 ? 317 ASN A OD1 1 
ATOM   2380 N  ND2 . ASN A 1 317 ? 20.500 -18.137 12.602  1.00 63.94 ? 317 ASN A ND2 1 
ATOM   2381 N  N   . HIS A 1 318 ? 24.706 -20.787 10.912  1.00 51.29 ? 318 HIS A N   1 
ATOM   2382 C  CA  . HIS A 1 318 ? 25.178 -22.156 10.846  1.00 51.17 ? 318 HIS A CA  1 
ATOM   2383 C  C   . HIS A 1 318 ? 26.406 -22.395 11.716  1.00 48.12 ? 318 HIS A C   1 
ATOM   2384 O  O   . HIS A 1 318 ? 26.867 -23.535 11.808  1.00 51.66 ? 318 HIS A O   1 
ATOM   2385 C  CB  . HIS A 1 318 ? 25.476 -22.542 9.397   1.00 49.16 ? 318 HIS A CB  1 
ATOM   2386 C  CG  . HIS A 1 318 ? 24.277 -22.526 8.497   1.00 52.09 ? 318 HIS A CG  1 
ATOM   2387 N  ND1 . HIS A 1 318 ? 23.671 -21.362 8.081   1.00 53.13 ? 318 HIS A ND1 1 
ATOM   2388 C  CD2 . HIS A 1 318 ? 23.600 -23.535 7.899   1.00 55.15 ? 318 HIS A CD2 1 
ATOM   2389 C  CE1 . HIS A 1 318 ? 22.666 -21.656 7.275   1.00 51.73 ? 318 HIS A CE1 1 
ATOM   2390 N  NE2 . HIS A 1 318 ? 22.601 -22.967 7.146   1.00 52.22 ? 318 HIS A NE2 1 
ATOM   2391 N  N   . LEU A 1 319 ? 26.936 -21.361 12.362  1.00 51.63 ? 319 LEU A N   1 
ATOM   2392 C  CA  . LEU A 1 319 ? 28.001 -21.551 13.337  1.00 49.43 ? 319 LEU A CA  1 
ATOM   2393 C  C   . LEU A 1 319 ? 27.487 -22.335 14.530  1.00 51.41 ? 319 LEU A C   1 
ATOM   2394 O  O   . LEU A 1 319 ? 26.358 -22.133 14.970  1.00 48.39 ? 319 LEU A O   1 
ATOM   2395 C  CB  . LEU A 1 319 ? 28.518 -20.210 13.820  1.00 47.09 ? 319 LEU A CB  1 
ATOM   2396 C  CG  . LEU A 1 319 ? 29.421 -19.452 12.856  1.00 46.27 ? 319 LEU A CG  1 
ATOM   2397 C  CD1 . LEU A 1 319 ? 29.775 -18.118 13.456  1.00 40.43 ? 319 LEU A CD1 1 
ATOM   2398 C  CD2 . LEU A 1 319 ? 30.670 -20.275 12.554  1.00 38.02 ? 319 LEU A CD2 1 
ATOM   2399 N  N   . ASP A 1 320 ? 28.322 -23.220 15.081  1.00 48.20 ? 320 ASP A N   1 
ATOM   2400 C  CA  . ASP A 1 320 ? 28.011 -23.869 16.354  1.00 48.70 ? 320 ASP A CA  1 
ATOM   2401 C  C   . ASP A 1 320 ? 28.804 -23.182 17.458  1.00 49.83 ? 320 ASP A C   1 
ATOM   2402 O  O   . ASP A 1 320 ? 30.016 -23.387 17.586  1.00 47.32 ? 320 ASP A O   1 
ATOM   2403 C  CB  . ASP A 1 320 ? 28.303 -25.366 16.310  1.00 50.68 ? 320 ASP A CB  1 
ATOM   2404 C  CG  . ASP A 1 320 ? 27.680 -26.110 17.480  1.00 53.05 ? 320 ASP A CG  1 
ATOM   2405 O  OD1 . ASP A 1 320 ? 26.486 -26.475 17.391  1.00 54.55 ? 320 ASP A OD1 1 
ATOM   2406 O  OD2 . ASP A 1 320 ? 28.386 -26.330 18.490  1.00 53.79 ? 320 ASP A OD2 1 
ATOM   2407 N  N   . PHE A 1 321 ? 28.124 -22.374 18.272  1.00 44.22 ? 321 PHE A N   1 
ATOM   2408 C  CA  . PHE A 1 321 ? 28.883 -21.571 19.211  1.00 47.42 ? 321 PHE A CA  1 
ATOM   2409 C  C   . PHE A 1 321 ? 29.454 -22.403 20.348  1.00 50.85 ? 321 PHE A C   1 
ATOM   2410 O  O   . PHE A 1 321 ? 30.476 -22.017 20.928  1.00 44.58 ? 321 PHE A O   1 
ATOM   2411 C  CB  . PHE A 1 321 ? 28.024 -20.413 19.704  1.00 49.43 ? 321 PHE A CB  1 
ATOM   2412 C  CG  . PHE A 1 321 ? 28.024 -19.247 18.749  1.00 51.37 ? 321 PHE A CG  1 
ATOM   2413 C  CD1 . PHE A 1 321 ? 27.156 -19.219 17.680  1.00 48.29 ? 321 PHE A CD1 1 
ATOM   2414 C  CD2 . PHE A 1 321 ? 28.943 -18.218 18.884  1.00 50.99 ? 321 PHE A CD2 1 
ATOM   2415 C  CE1 . PHE A 1 321 ? 27.172 -18.169 16.781  1.00 47.85 ? 321 PHE A CE1 1 
ATOM   2416 C  CE2 . PHE A 1 321 ? 28.960 -17.165 17.981  1.00 52.46 ? 321 PHE A CE2 1 
ATOM   2417 C  CZ  . PHE A 1 321 ? 28.076 -17.143 16.934  1.00 49.94 ? 321 PHE A CZ  1 
ATOM   2418 N  N   . ASP A 1 322 ? 28.850 -23.548 20.657  1.00 47.08 ? 322 ASP A N   1 
ATOM   2419 C  CA  . ASP A 1 322 ? 29.461 -24.426 21.650  1.00 52.17 ? 322 ASP A CA  1 
ATOM   2420 C  C   . ASP A 1 322 ? 30.779 -24.984 21.128  1.00 48.29 ? 322 ASP A C   1 
ATOM   2421 O  O   . ASP A 1 322 ? 31.790 -24.997 21.846  1.00 46.91 ? 322 ASP A O   1 
ATOM   2422 C  CB  . ASP A 1 322 ? 28.505 -25.563 22.014  1.00 53.30 ? 322 ASP A CB  1 
ATOM   2423 C  CG  . ASP A 1 322 ? 27.497 -25.165 23.088  1.00 56.90 ? 322 ASP A CG  1 
ATOM   2424 O  OD1 . ASP A 1 322 ? 27.650 -24.070 23.677  1.00 56.71 ? 322 ASP A OD1 1 
ATOM   2425 O  OD2 . ASP A 1 322 ? 26.562 -25.962 23.339  1.00 56.38 ? 322 ASP A OD2 1 
ATOM   2426 N  N   . THR A 1 323 ? 30.788 -25.426 19.870  1.00 48.87 ? 323 THR A N   1 
ATOM   2427 C  CA  . THR A 1 323 ? 32.032 -25.869 19.251  1.00 48.22 ? 323 THR A CA  1 
ATOM   2428 C  C   . THR A 1 323 ? 33.066 -24.746 19.240  1.00 42.79 ? 323 THR A C   1 
ATOM   2429 O  O   . THR A 1 323 ? 34.253 -24.979 19.513  1.00 42.53 ? 323 THR A O   1 
ATOM   2430 C  CB  . THR A 1 323 ? 31.754 -26.373 17.832  1.00 50.16 ? 323 THR A CB  1 
ATOM   2431 O  OG1 . THR A 1 323 ? 30.800 -27.443 17.872  1.00 48.80 ? 323 THR A OG1 1 
ATOM   2432 C  CG2 . THR A 1 323 ? 33.037 -26.872 17.182  1.00 47.42 ? 323 THR A CG2 1 
ATOM   2433 N  N   . ILE A 1 324 ? 32.633 -23.520 18.967  1.00 40.02 ? 324 ILE A N   1 
ATOM   2434 C  CA  . ILE A 1 324 ? 33.597 -22.385 18.860  1.00 38.49 ? 324 ILE A CA  1 
ATOM   2435 C  C   . ILE A 1 324 ? 34.203 -22.113 20.237  1.00 39.79 ? 324 ILE A C   1 
ATOM   2436 O  O   . ILE A 1 324 ? 35.397 -21.811 20.311  1.00 40.38 ? 324 ILE A O   1 
ATOM   2437 C  CB  . ILE A 1 324 ? 32.927 -21.132 18.255  1.00 41.15 ? 324 ILE A CB  1 
ATOM   2438 C  CG1 . ILE A 1 324 ? 32.559 -21.335 16.784  1.00 40.46 ? 324 ILE A CG1 1 
ATOM   2439 C  CG2 . ILE A 1 324 ? 33.793 -19.900 18.460  1.00 38.48 ? 324 ILE A CG2 1 
ATOM   2440 C  CD1 . ILE A 1 324 ? 31.611 -20.296 16.243  1.00 41.53 ? 324 ILE A CD1 1 
ATOM   2441 N  N   . ARG A 1 325 ? 33.392 -22.226 21.285  1.00 43.31 ? 325 ARG A N   1 
ATOM   2442 C  CA  . ARG A 1 325 ? 33.879 -21.996 22.665  1.00 40.96 ? 325 ARG A CA  1 
ATOM   2443 C  C   . ARG A 1 325 ? 34.867 -23.099 23.034  1.00 37.76 ? 325 ARG A C   1 
ATOM   2444 O  O   . ARG A 1 325 ? 35.863 -22.804 23.696  1.00 41.95 ? 325 ARG A O   1 
ATOM   2445 C  CB  . ARG A 1 325 ? 32.705 -21.972 23.644  1.00 45.55 ? 325 ARG A CB  1 
ATOM   2446 C  CG  . ARG A 1 325 ? 31.804 -20.754 23.503  1.00 52.73 ? 325 ARG A CG  1 
ATOM   2447 C  CD  . ARG A 1 325 ? 30.733 -20.698 24.575  1.00 56.64 ? 325 ARG A CD  1 
ATOM   2448 N  NE  . ARG A 1 325 ? 29.424 -21.066 24.060  1.00 58.84 ? 325 ARG A NE  1 
ATOM   2449 C  CZ  . ARG A 1 325 ? 28.509 -20.198 23.653  1.00 59.61 ? 325 ARG A CZ  1 
ATOM   2450 N  NH1 . ARG A 1 325 ? 28.758 -18.902 23.706  1.00 60.70 ? 325 ARG A NH1 1 
ATOM   2451 N  NH2 . ARG A 1 325 ? 27.347 -20.626 23.196  1.00 57.69 ? 325 ARG A NH2 1 
ATOM   2452 N  N   . ASP A 1 326 ? 34.582 -24.319 22.601  1.00 40.94 ? 326 ASP A N   1 
ATOM   2453 C  CA  . ASP A 1 326 ? 35.497 -25.448 22.877  1.00 39.84 ? 326 ASP A CA  1 
ATOM   2454 C  C   . ASP A 1 326 ? 36.834 -25.169 22.187  1.00 40.54 ? 326 ASP A C   1 
ATOM   2455 O  O   . ASP A 1 326 ? 37.873 -25.340 22.828  1.00 40.29 ? 326 ASP A O   1 
ATOM   2456 C  CB  . ASP A 1 326 ? 34.846 -26.764 22.465  1.00 43.67 ? 326 ASP A CB  1 
ATOM   2457 C  CG  . ASP A 1 326 ? 33.766 -27.227 23.424  1.00 49.70 ? 326 ASP A CG  1 
ATOM   2458 O  OD1 . ASP A 1 326 ? 33.499 -26.502 24.394  1.00 48.31 ? 326 ASP A OD1 1 
ATOM   2459 O  OD2 . ASP A 1 326 ? 33.209 -28.307 23.191  1.00 47.95 ? 326 ASP A OD2 1 
ATOM   2460 N  N   . TRP A 1 327 ? 36.788 -24.724 20.934  1.00 41.69 ? 327 TRP A N   1 
ATOM   2461 C  CA  . TRP A 1 327 ? 38.026 -24.367 20.241  1.00 38.54 ? 327 TRP A CA  1 
ATOM   2462 C  C   . TRP A 1 327 ? 38.797 -23.309 21.007  1.00 38.40 ? 327 TRP A C   1 
ATOM   2463 O  O   . TRP A 1 327 ? 40.024 -23.388 21.128  1.00 36.22 ? 327 TRP A O   1 
ATOM   2464 C  CB  . TRP A 1 327 ? 37.735 -23.867 18.829  1.00 38.48 ? 327 TRP A CB  1 
ATOM   2465 C  CG  . TRP A 1 327 ? 37.671 -24.932 17.807  1.00 37.95 ? 327 TRP A CG  1 
ATOM   2466 C  CD1 . TRP A 1 327 ? 36.609 -25.224 17.013  1.00 34.94 ? 327 TRP A CD1 1 
ATOM   2467 C  CD2 . TRP A 1 327 ? 38.722 -25.847 17.432  1.00 34.60 ? 327 TRP A CD2 1 
ATOM   2468 N  NE1 . TRP A 1 327 ? 36.919 -26.267 16.172  1.00 40.03 ? 327 TRP A NE1 1 
ATOM   2469 C  CE2 . TRP A 1 327 ? 38.210 -26.666 16.409  1.00 39.45 ? 327 TRP A CE2 1 
ATOM   2470 C  CE3 . TRP A 1 327 ? 40.042 -26.036 17.858  1.00 37.27 ? 327 TRP A CE3 1 
ATOM   2471 C  CZ2 . TRP A 1 327 ? 38.963 -27.686 15.814  1.00 41.58 ? 327 TRP A CZ2 1 
ATOM   2472 C  CZ3 . TRP A 1 327 ? 40.796 -27.055 17.273  1.00 38.90 ? 327 TRP A CZ3 1 
ATOM   2473 C  CH2 . TRP A 1 327 ? 40.249 -27.868 16.264  1.00 37.33 ? 327 TRP A CH2 1 
ATOM   2474 N  N   . SER A 1 328 ? 38.110 -22.255 21.462  1.00 37.04 ? 328 SER A N   1 
ATOM   2475 C  CA  . SER A 1 328 ? 38.841 -21.208 22.164  1.00 32.06 ? 328 SER A CA  1 
ATOM   2476 C  C   . SER A 1 328 ? 39.529 -21.766 23.403  1.00 36.83 ? 328 SER A C   1 
ATOM   2477 O  O   . SER A 1 328 ? 40.692 -21.443 23.685  1.00 36.85 ? 328 SER A O   1 
ATOM   2478 C  CB  . SER A 1 328 ? 37.902 -20.059 22.561  1.00 39.18 ? 328 SER A CB  1 
ATOM   2479 O  OG  . SER A 1 328 ? 38.663 -19.072 23.254  1.00 41.90 ? 328 SER A OG  1 
ATOM   2480 N  N   . LEU A 1 329 ? 38.813 -22.595 24.166  1.00 38.79 ? 329 LEU A N   1 
ATOM   2481 C  CA  . LEU A 1 329 ? 39.409 -23.205 25.353  1.00 38.77 ? 329 LEU A CA  1 
ATOM   2482 C  C   . LEU A 1 329 ? 40.607 -24.093 24.989  1.00 34.03 ? 329 LEU A C   1 
ATOM   2483 O  O   . LEU A 1 329 ? 41.648 -24.067 25.660  1.00 37.64 ? 329 LEU A O   1 
ATOM   2484 C  CB  . LEU A 1 329 ? 38.342 -24.024 26.080  1.00 44.14 ? 329 LEU A CB  1 
ATOM   2485 C  CG  . LEU A 1 329 ? 38.565 -24.392 27.544  1.00 48.18 ? 329 LEU A CG  1 
ATOM   2486 C  CD1 . LEU A 1 329 ? 38.279 -23.151 28.357  1.00 50.43 ? 329 LEU A CD1 1 
ATOM   2487 C  CD2 . LEU A 1 329 ? 37.597 -25.487 27.928  1.00 51.01 ? 329 LEU A CD2 1 
ATOM   2488 N  N   . LEU A 1 330 ? 40.462 -24.886 23.932  1.00 38.68 ? 330 LEU A N   1 
ATOM   2489 C  CA  . LEU A 1 330 ? 41.525 -25.791 23.501  1.00 36.45 ? 330 LEU A CA  1 
ATOM   2490 C  C   . LEU A 1 330 ? 42.775 -25.031 23.075  1.00 36.21 ? 330 LEU A C   1 
ATOM   2491 O  O   . LEU A 1 330 ? 43.891 -25.368 23.481  1.00 36.02 ? 330 LEU A O   1 
ATOM   2492 C  CB  . LEU A 1 330 ? 41.002 -26.654 22.372  1.00 38.96 ? 330 LEU A CB  1 
ATOM   2493 C  CG  . LEU A 1 330 ? 41.978 -27.687 21.860  1.00 39.95 ? 330 LEU A CG  1 
ATOM   2494 C  CD1 . LEU A 1 330 ? 42.497 -28.521 23.051  1.00 42.28 ? 330 LEU A CD1 1 
ATOM   2495 C  CD2 . LEU A 1 330 ? 41.279 -28.539 20.815  1.00 41.93 ? 330 LEU A CD2 1 
ATOM   2496 N  N   . ILE A 1 331 ? 42.614 -24.001 22.237  1.00 35.64 ? 331 ILE A N   1 
ATOM   2497 C  CA  . ILE A 1 331 ? 43.785 -23.242 21.818  1.00 35.30 ? 331 ILE A CA  1 
ATOM   2498 C  C   . ILE A 1 331 ? 44.393 -22.496 22.993  1.00 32.07 ? 331 ILE A C   1 
ATOM   2499 O  O   . ILE A 1 331 ? 45.627 -22.360 23.082  1.00 34.43 ? 331 ILE A O   1 
ATOM   2500 C  CB  . ILE A 1 331 ? 43.432 -22.296 20.649  1.00 33.82 ? 331 ILE A CB  1 
ATOM   2501 C  CG1 . ILE A 1 331 ? 42.764 -23.076 19.528  1.00 32.68 ? 331 ILE A CG1 1 
ATOM   2502 C  CG2 . ILE A 1 331 ? 44.652 -21.564 20.159  1.00 33.70 ? 331 ILE A CG2 1 
ATOM   2503 C  CD1 . ILE A 1 331 ? 43.633 -24.189 18.927  1.00 39.90 ? 331 ILE A CD1 1 
ATOM   2504 N  N   . THR A 1 332 ? 43.574 -22.007 23.939  1.00 32.64 ? 332 THR A N   1 
ATOM   2505 C  CA  . THR A 1 332 ? 44.169 -21.412 25.134  1.00 30.25 ? 332 THR A CA  1 
ATOM   2506 C  C   . THR A 1 332 ? 45.037 -22.433 25.870  1.00 30.15 ? 332 THR A C   1 
ATOM   2507 O  O   . THR A 1 332 ? 46.166 -22.137 26.278  1.00 32.48 ? 332 THR A O   1 
ATOM   2508 C  CB  . THR A 1 332 ? 43.080 -20.868 26.068  1.00 38.04 ? 332 THR A CB  1 
ATOM   2509 O  OG1 . THR A 1 332 ? 42.130 -20.098 25.309  1.00 39.09 ? 332 THR A OG1 1 
ATOM   2510 C  CG2 . THR A 1 332 ? 43.700 -19.986 27.114  1.00 40.71 ? 332 THR A CG2 1 
ATOM   2511 N  N   . ALA A 1 333 ? 44.516 -23.641 26.036  1.00 32.21 ? 333 ALA A N   1 
ATOM   2512 C  CA  . ALA A 1 333 ? 45.253 -24.663 26.774  1.00 36.94 ? 333 ALA A CA  1 
ATOM   2513 C  C   . ALA A 1 333 ? 46.542 -25.023 26.055  1.00 31.50 ? 333 ALA A C   1 
ATOM   2514 O  O   . ALA A 1 333 ? 47.610 -25.120 26.678  1.00 32.66 ? 333 ALA A O   1 
ATOM   2515 C  CB  . ALA A 1 333 ? 44.367 -25.885 26.959  1.00 34.33 ? 333 ALA A CB  1 
ATOM   2516 N  N   . PHE A 1 334 ? 46.468 -25.157 24.725  1.00 35.39 ? 334 PHE A N   1 
ATOM   2517 C  CA  . PHE A 1 334 ? 47.655 -25.497 23.951  1.00 31.84 ? 334 PHE A CA  1 
ATOM   2518 C  C   . PHE A 1 334 ? 48.713 -24.418 24.083  1.00 36.83 ? 334 PHE A C   1 
ATOM   2519 O  O   . PHE A 1 334 ? 49.881 -24.710 24.374  1.00 31.87 ? 334 PHE A O   1 
ATOM   2520 C  CB  . PHE A 1 334 ? 47.289 -25.748 22.489  1.00 31.68 ? 334 PHE A CB  1 
ATOM   2521 C  CG  . PHE A 1 334 ? 48.472 -26.118 21.649  1.00 36.64 ? 334 PHE A CG  1 
ATOM   2522 C  CD1 . PHE A 1 334 ? 48.892 -27.443 21.561  1.00 36.42 ? 334 PHE A CD1 1 
ATOM   2523 C  CD2 . PHE A 1 334 ? 49.189 -25.145 20.978  1.00 34.48 ? 334 PHE A CD2 1 
ATOM   2524 C  CE1 . PHE A 1 334 ? 50.022 -27.784 20.805  1.00 29.31 ? 334 PHE A CE1 1 
ATOM   2525 C  CE2 . PHE A 1 334 ? 50.291 -25.478 20.203  1.00 31.58 ? 334 PHE A CE2 1 
ATOM   2526 C  CZ  . PHE A 1 334 ? 50.696 -26.815 20.122  1.00 36.48 ? 334 PHE A CZ  1 
ATOM   2527 N  N   . ALA A 1 335 ? 48.324 -23.149 23.902  1.00 31.95 ? 335 ALA A N   1 
ATOM   2528 C  CA  . ALA A 1 335 ? 49.303 -22.078 24.026  1.00 31.80 ? 335 ALA A CA  1 
ATOM   2529 C  C   . ALA A 1 335 ? 49.895 -22.014 25.424  1.00 32.30 ? 335 ALA A C   1 
ATOM   2530 O  O   . ALA A 1 335 ? 51.104 -21.797 25.588  1.00 35.15 ? 335 ALA A O   1 
ATOM   2531 C  CB  . ALA A 1 335 ? 48.663 -20.735 23.673  1.00 34.68 ? 335 ALA A CB  1 
ATOM   2532 N  N   . ALA A 1 336 ? 49.059 -22.187 26.452  1.00 33.89 ? 336 ALA A N   1 
ATOM   2533 C  CA  . ALA A 1 336 ? 49.566 -22.110 27.821  1.00 33.44 ? 336 ALA A CA  1 
ATOM   2534 C  C   . ALA A 1 336 ? 50.569 -23.229 28.093  1.00 34.31 ? 336 ALA A C   1 
ATOM   2535 O  O   . ALA A 1 336 ? 51.611 -22.999 28.720  1.00 40.74 ? 336 ALA A O   1 
ATOM   2536 C  CB  . ALA A 1 336 ? 48.410 -22.188 28.816  1.00 34.14 ? 336 ALA A CB  1 
ATOM   2537 N  N   . GLU A 1 337 ? 50.263 -24.446 27.636  1.00 36.65 ? 337 GLU A N   1 
ATOM   2538 C  CA  A GLU A 1 337 ? 51.240 -25.553 27.786  0.70 38.18 ? 337 GLU A CA  1 
ATOM   2539 C  CA  B GLU A 1 337 ? 51.231 -25.561 27.776  0.30 38.41 ? 337 GLU A CA  1 
ATOM   2540 C  C   . GLU A 1 337 ? 52.523 -25.194 27.045  1.00 38.34 ? 337 GLU A C   1 
ATOM   2541 O  O   . GLU A 1 337 ? 53.606 -25.259 27.637  1.00 38.24 ? 337 GLU A O   1 
ATOM   2542 C  CB  A GLU A 1 337 ? 50.666 -26.850 27.236  0.70 39.73 ? 337 GLU A CB  1 
ATOM   2543 C  CB  B GLU A 1 337 ? 50.612 -26.832 27.202  0.30 39.76 ? 337 GLU A CB  1 
ATOM   2544 C  CG  A GLU A 1 337 ? 51.382 -28.089 27.738  0.70 42.19 ? 337 GLU A CG  1 
ATOM   2545 C  CG  B GLU A 1 337 ? 51.452 -28.077 27.394  0.30 41.99 ? 337 GLU A CG  1 
ATOM   2546 C  CD  A GLU A 1 337 ? 50.510 -29.328 27.844  0.70 43.50 ? 337 GLU A CD  1 
ATOM   2547 C  CD  B GLU A 1 337 ? 50.879 -29.284 26.672  0.30 41.78 ? 337 GLU A CD  1 
ATOM   2548 O  OE1 A GLU A 1 337 ? 50.275 -29.970 26.806  0.70 40.82 ? 337 GLU A OE1 1 
ATOM   2549 O  OE1 B GLU A 1 337 ? 51.059 -29.373 25.442  0.30 38.20 ? 337 GLU A OE1 1 
ATOM   2550 O  OE2 A GLU A 1 337 ? 50.069 -29.646 28.967  0.70 43.29 ? 337 GLU A OE2 1 
ATOM   2551 O  OE2 B GLU A 1 337 ? 50.237 -30.117 27.336  0.30 41.62 ? 337 GLU A OE2 1 
ATOM   2552 N  N   . TRP A 1 338 ? 52.425 -24.795 25.774  1.00 38.20 ? 338 TRP A N   1 
ATOM   2553 C  CA  . TRP A 1 338 ? 53.613 -24.519 24.966  1.00 39.05 ? 338 TRP A CA  1 
ATOM   2554 C  C   . TRP A 1 338 ? 54.490 -23.462 25.616  1.00 41.62 ? 338 TRP A C   1 
ATOM   2555 O  O   . TRP A 1 338 ? 55.724 -23.564 25.604  1.00 40.79 ? 338 TRP A O   1 
ATOM   2556 C  CB  . TRP A 1 338 ? 53.179 -24.067 23.568  1.00 37.72 ? 338 TRP A CB  1 
ATOM   2557 C  CG  . TRP A 1 338 ? 54.257 -24.083 22.509  1.00 33.75 ? 338 TRP A CG  1 
ATOM   2558 C  CD1 . TRP A 1 338 ? 54.434 -25.042 21.531  1.00 38.23 ? 338 TRP A CD1 1 
ATOM   2559 C  CD2 . TRP A 1 338 ? 55.271 -23.103 22.290  1.00 35.61 ? 338 TRP A CD2 1 
ATOM   2560 N  NE1 . TRP A 1 338 ? 55.513 -24.718 20.743  1.00 35.77 ? 338 TRP A NE1 1 
ATOM   2561 C  CE2 . TRP A 1 338 ? 56.039 -23.532 21.175  1.00 31.83 ? 338 TRP A CE2 1 
ATOM   2562 C  CE3 . TRP A 1 338 ? 55.617 -21.911 22.924  1.00 36.23 ? 338 TRP A CE3 1 
ATOM   2563 C  CZ2 . TRP A 1 338 ? 57.118 -22.807 20.692  1.00 38.92 ? 338 TRP A CZ2 1 
ATOM   2564 C  CZ3 . TRP A 1 338 ? 56.689 -21.190 22.435  1.00 39.90 ? 338 TRP A CZ3 1 
ATOM   2565 C  CH2 . TRP A 1 338 ? 57.428 -21.639 21.330  1.00 41.57 ? 338 TRP A CH2 1 
ATOM   2566 N  N   . LEU A 1 339 ? 53.873 -22.429 26.176  1.00 37.43 ? 339 LEU A N   1 
ATOM   2567 C  CA  . LEU A 1 339 ? 54.609 -21.362 26.830  1.00 36.46 ? 339 LEU A CA  1 
ATOM   2568 C  C   . LEU A 1 339 ? 54.975 -21.695 28.275  1.00 38.36 ? 339 LEU A C   1 
ATOM   2569 O  O   . LEU A 1 339 ? 55.663 -20.901 28.912  1.00 37.67 ? 339 LEU A O   1 
ATOM   2570 C  CB  . LEU A 1 339 ? 53.791 -20.057 26.769  1.00 41.67 ? 339 LEU A CB  1 
ATOM   2571 C  CG  . LEU A 1 339 ? 53.728 -19.496 25.342  1.00 39.30 ? 339 LEU A CG  1 
ATOM   2572 C  CD1 . LEU A 1 339 ? 52.587 -18.499 25.164  1.00 38.72 ? 339 LEU A CD1 1 
ATOM   2573 C  CD2 . LEU A 1 339 ? 55.044 -18.858 24.911  1.00 33.25 ? 339 LEU A CD2 1 
ATOM   2574 N  N   . GLY A 1 340 ? 54.545 -22.850 28.789  1.00 41.18 ? 340 GLY A N   1 
ATOM   2575 C  CA  . GLY A 1 340 ? 54.878 -23.277 30.137  1.00 40.55 ? 340 GLY A CA  1 
ATOM   2576 C  C   . GLY A 1 340 ? 54.258 -22.421 31.222  1.00 45.80 ? 340 GLY A C   1 
ATOM   2577 O  O   . GLY A 1 340 ? 54.935 -21.968 32.151  1.00 45.52 ? 340 GLY A O   1 
ATOM   2578 N  N   . LEU A 1 341 ? 52.960 -22.194 31.115  1.00 41.18 ? 341 LEU A N   1 
ATOM   2579 C  CA  . LEU A 1 341 ? 52.289 -21.314 32.051  1.00 44.60 ? 341 LEU A CA  1 
ATOM   2580 C  C   . LEU A 1 341 ? 51.663 -22.068 33.211  1.00 45.70 ? 341 LEU A C   1 
ATOM   2581 O  O   . LEU A 1 341 ? 50.905 -21.477 33.982  1.00 44.76 ? 341 LEU A O   1 
ATOM   2582 C  CB  . LEU A 1 341 ? 51.231 -20.494 31.317  1.00 41.03 ? 341 LEU A CB  1 
ATOM   2583 C  CG  . LEU A 1 341 ? 51.726 -19.668 30.142  1.00 41.38 ? 341 LEU A CG  1 
ATOM   2584 C  CD1 . LEU A 1 341 ? 50.557 -18.877 29.535  1.00 38.26 ? 341 LEU A CD1 1 
ATOM   2585 C  CD2 . LEU A 1 341 ? 52.826 -18.733 30.581  1.00 45.51 ? 341 LEU A CD2 1 
ATOM   2586 N  N   . GLN A 1 342 ? 52.009 -23.336 33.344  1.00 44.60 ? 342 GLN A N   1 
ATOM   2587 C  CA  . GLN A 1 342 ? 51.454 -24.156 34.443  1.00 48.28 ? 342 GLN A CA  1 
ATOM   2588 C  C   . GLN A 1 342 ? 51.655 -23.417 35.770  1.00 43.86 ? 342 GLN A C   1 
ATOM   2589 O  O   . GLN A 1 342 ? 52.762 -22.933 36.020  1.00 44.89 ? 342 GLN A O   1 
ATOM   2590 C  CB  . GLN A 1 342 ? 52.082 -25.552 34.434  1.00 48.07 ? 342 GLN A CB  1 
ATOM   2591 C  CG  . GLN A 1 342 ? 53.597 -25.547 34.548  1.00 48.61 ? 342 GLN A CG  1 
ATOM   2592 C  CD  . GLN A 1 342 ? 54.273 -25.517 33.201  1.00 54.19 ? 342 GLN A CD  1 
ATOM   2593 O  OE1 . GLN A 1 342 ? 53.623 -25.448 32.162  1.00 55.10 ? 342 GLN A OE1 1 
ATOM   2594 N  NE2 . GLN A 1 342 ? 55.594 -25.564 33.213  1.00 51.53 ? 342 GLN A NE2 1 
ATOM   2595 N  N   . GLY A 1 343 ? 50.588 -23.309 36.560  1.00 51.36 ? 343 GLY A N   1 
ATOM   2596 C  CA  . GLY A 1 343 ? 50.671 -22.660 37.882  1.00 50.49 ? 343 GLY A CA  1 
ATOM   2597 C  C   . GLY A 1 343 ? 50.380 -21.175 37.826  1.00 54.41 ? 343 GLY A C   1 
ATOM   2598 O  O   . GLY A 1 343 ? 50.351 -20.545 38.892  1.00 52.65 ? 343 GLY A O   1 
ATOM   2599 N  N   . PHE A 1 344 ? 50.172 -20.631 36.630  1.00 50.88 ? 344 PHE A N   1 
ATOM   2600 C  CA  . PHE A 1 344 ? 49.981 -19.170 36.496  1.00 49.32 ? 344 PHE A CA  1 
ATOM   2601 C  C   . PHE A 1 344 ? 48.614 -18.869 35.880  1.00 52.96 ? 344 PHE A C   1 
ATOM   2602 O  O   . PHE A 1 344 ? 48.396 -17.718 35.499  1.00 58.83 ? 344 PHE A O   1 
ATOM   2603 C  CB  . PHE A 1 344 ? 51.117 -18.592 35.660  1.00 47.69 ? 344 PHE A CB  1 
ATOM   2604 C  CG  . PHE A 1 344 ? 52.481 -18.618 36.296  1.00 54.11 ? 344 PHE A CG  1 
ATOM   2605 C  CD1 . PHE A 1 344 ? 52.820 -17.710 37.284  1.00 53.11 ? 344 PHE A CD1 1 
ATOM   2606 C  CD2 . PHE A 1 344 ? 53.435 -19.531 35.884  1.00 53.97 ? 344 PHE A CD2 1 
ATOM   2607 C  CE1 . PHE A 1 344 ? 54.080 -17.723 37.857  1.00 57.16 ? 344 PHE A CE1 1 
ATOM   2608 C  CE2 . PHE A 1 344 ? 54.695 -19.544 36.459  1.00 58.29 ? 344 PHE A CE2 1 
ATOM   2609 C  CZ  . PHE A 1 344 ? 55.015 -18.641 37.443  1.00 59.13 ? 344 PHE A CZ  1 
ATOM   2610 N  N   . MET A 1 345 ? 47.718 -19.852 35.826  1.00 48.48 ? 345 MET A N   1 
ATOM   2611 C  CA  . MET A 1 345 ? 46.412 -19.649 35.146  1.00 57.85 ? 345 MET A CA  1 
ATOM   2612 C  C   . MET A 1 345 ? 45.335 -19.144 36.116  1.00 61.61 ? 345 MET A C   1 
ATOM   2613 O  O   . MET A 1 345 ? 44.235 -18.851 35.637  1.00 62.63 ? 345 MET A O   1 
ATOM   2614 C  CB  . MET A 1 345 ? 45.912 -20.937 34.491  1.00 52.76 ? 345 MET A CB  1 
ATOM   2615 C  CG  . MET A 1 345 ? 45.660 -20.770 33.016  1.00 62.63 ? 345 MET A CG  1 
ATOM   2616 S  SD  . MET A 1 345 ? 47.217 -20.434 32.175  1.00 64.61 ? 345 MET A SD  1 
ATOM   2617 C  CE  . MET A 1 345 ? 48.158 -21.855 32.726  1.00 52.00 ? 345 MET A CE  1 
ATOM   2618 N  N   . ASP A 1 346 ? 45.617 -19.071 37.413  1.00 65.50 ? 346 ASP A N   1 
ATOM   2619 C  CA  . ASP A 1 346 ? 44.546 -18.651 38.355  1.00 70.29 ? 346 ASP A CA  1 
ATOM   2620 C  C   . ASP A 1 346 ? 44.114 -17.239 37.984  1.00 73.31 ? 346 ASP A C   1 
ATOM   2621 O  O   . ASP A 1 346 ? 44.985 -16.366 37.903  1.00 72.02 ? 346 ASP A O   1 
ATOM   2622 C  CB  . ASP A 1 346 ? 45.000 -18.666 39.812  1.00 72.46 ? 346 ASP A CB  1 
ATOM   2623 C  CG  . ASP A 1 346 ? 44.560 -17.439 40.590  1.00 80.32 ? 346 ASP A CG  1 
ATOM   2624 O  OD1 . ASP A 1 346 ? 43.344 -17.274 40.781  1.00 81.07 ? 346 ASP A OD1 1 
ATOM   2625 O  OD2 . ASP A 1 346 ? 45.438 -16.653 40.993  1.00 83.00 ? 346 ASP A OD2 1 
ATOM   2626 N  N   . ASN A 1 347 ? 42.813 -17.032 37.787  1.00 76.17 ? 347 ASN A N   1 
ATOM   2627 C  CA  . ASN A 1 347 ? 42.312 -15.669 37.474  1.00 77.34 ? 347 ASN A CA  1 
ATOM   2628 C  C   . ASN A 1 347 ? 41.352 -15.207 38.576  1.00 82.05 ? 347 ASN A C   1 
ATOM   2629 O  O   . ASN A 1 347 ? 40.510 -14.335 38.286  1.00 82.22 ? 347 ASN A O   1 
ATOM   2630 C  CB  . ASN A 1 347 ? 41.711 -15.590 36.070  1.00 78.49 ? 347 ASN A CB  1 
ATOM   2631 C  CG  . ASN A 1 347 ? 42.702 -15.065 35.055  1.00 79.05 ? 347 ASN A CG  1 
ATOM   2632 O  OD1 . ASN A 1 347 ? 43.281 -13.998 35.241  1.00 79.67 ? 347 ASN A OD1 1 
ATOM   2633 N  ND2 . ASN A 1 347 ? 42.909 -15.808 33.981  1.00 80.26 ? 347 ASN A ND2 1 
ATOM   2634 N  N   . HIS A 1 348 ? 41.458 -15.773 39.785  1.00 81.51 ? 348 HIS A N   1 
ATOM   2635 C  CA  . HIS A 1 348 ? 40.632 -15.268 40.914  1.00 80.00 ? 348 HIS A CA  1 
ATOM   2636 C  C   . HIS A 1 348 ? 41.007 -13.804 41.152  1.00 77.43 ? 348 HIS A C   1 
ATOM   2637 O  O   . HIS A 1 348 ? 42.134 -13.432 40.781  1.00 76.11 ? 348 HIS A O   1 
ATOM   2638 C  CB  . HIS A 1 348 ? 40.872 -16.078 42.189  1.00 75.33 ? 348 HIS A CB  1 
ATOM   2639 C  CG  . HIS A 1 348 ? 41.472 -15.267 43.289  1.00 76.62 ? 348 HIS A CG  1 
ATOM   2640 N  ND1 . HIS A 1 348 ? 42.803 -14.900 43.295  1.00 77.86 ? 348 HIS A ND1 1 
ATOM   2641 C  CD2 . HIS A 1 348 ? 40.926 -14.730 44.402  1.00 71.32 ? 348 HIS A CD2 1 
ATOM   2642 C  CE1 . HIS A 1 348 ? 43.054 -14.182 44.370  1.00 77.31 ? 348 HIS A CE1 1 
ATOM   2643 N  NE2 . HIS A 1 348 ? 41.919 -14.066 45.067  1.00 74.02 ? 348 HIS A NE2 1 
ATOM   2644 N  N   . HIS A 1 349 ? 40.121 -13.002 41.740  1.00 73.22 ? 349 HIS A N   1 
ATOM   2645 C  CA  . HIS A 1 349 ? 40.505 -11.579 41.904  1.00 65.44 ? 349 HIS A CA  1 
ATOM   2646 C  C   . HIS A 1 349 ? 40.755 -11.266 43.375  1.00 63.53 ? 349 HIS A C   1 
ATOM   2647 O  O   . HIS A 1 349 ? 39.965 -11.702 44.219  1.00 65.82 ? 349 HIS A O   1 
ATOM   2648 C  CB  . HIS A 1 349 ? 39.492 -10.620 41.279  1.00 65.27 ? 349 HIS A CB  1 
ATOM   2649 C  CG  . HIS A 1 349 ? 40.103 -9.291  41.000  1.00 63.48 ? 349 HIS A CG  1 
ATOM   2650 N  ND1 . HIS A 1 349 ? 40.208 -8.316  41.968  1.00 62.23 ? 349 HIS A ND1 1 
ATOM   2651 C  CD2 . HIS A 1 349 ? 40.690 -8.793  39.892  1.00 60.54 ? 349 HIS A CD2 1 
ATOM   2652 C  CE1 . HIS A 1 349 ? 40.807 -7.261  41.459  1.00 64.12 ? 349 HIS A CE1 1 
ATOM   2653 N  NE2 . HIS A 1 349 ? 41.120 -7.531  40.188  1.00 58.50 ? 349 HIS A NE2 1 
ATOM   2654 N  N   . HIS A 1 350 ? 41.832 -10.537 43.648  1.00 64.80 ? 350 HIS A N   1 
ATOM   2655 C  CA  . HIS A 1 350 ? 42.198 -10.182 45.040  1.00 60.44 ? 350 HIS A CA  1 
ATOM   2656 C  C   . HIS A 1 350 ? 41.173 -9.219  45.620  1.00 52.37 ? 350 HIS A C   1 
ATOM   2657 O  O   . HIS A 1 350 ? 40.607 -8.451  44.843  1.00 53.19 ? 350 HIS A O   1 
ATOM   2658 C  CB  . HIS A 1 350 ? 43.574 -9.536  45.020  1.00 58.60 ? 350 HIS A CB  1 
ATOM   2659 C  CG  . HIS A 1 350 ? 43.619 -8.289  44.210  1.00 62.64 ? 350 HIS A CG  1 
ATOM   2660 N  ND1 . HIS A 1 350 ? 43.856 -7.055  44.773  1.00 61.44 ? 350 HIS A ND1 1 
ATOM   2661 C  CD2 . HIS A 1 350 ? 43.454 -8.080  42.888  1.00 61.22 ? 350 HIS A CD2 1 
ATOM   2662 C  CE1 . HIS A 1 350 ? 43.838 -6.136  43.833  1.00 63.21 ? 350 HIS A CE1 1 
ATOM   2663 N  NE2 . HIS A 1 350 ? 43.593 -6.739  42.668  1.00 64.33 ? 350 HIS A NE2 1 
ATOM   2664 N  N   . HIS A 1 351 ? 40.950 -9.279  46.928  1.00 48.65 ? 351 HIS A N   1 
ATOM   2665 C  CA  . HIS A 1 351 ? 40.031 -8.321  47.597  1.00 46.91 ? 351 HIS A CA  1 
ATOM   2666 C  C   . HIS A 1 351 ? 38.597 -8.576  47.151  1.00 46.82 ? 351 HIS A C   1 
ATOM   2667 O  O   . HIS A 1 351 ? 37.795 -7.640  47.214  1.00 42.51 ? 351 HIS A O   1 
ATOM   2668 C  CB  . HIS A 1 351 ? 40.480 -6.874  47.357  1.00 46.87 ? 351 HIS A CB  1 
ATOM   2669 C  CG  . HIS A 1 351 ? 41.773 -6.535  48.017  1.00 51.59 ? 351 HIS A CG  1 
ATOM   2670 N  ND1 . HIS A 1 351 ? 42.976 -6.604  47.352  1.00 51.74 ? 351 HIS A ND1 1 
ATOM   2671 C  CD2 . HIS A 1 351 ? 42.055 -6.128  49.272  1.00 49.52 ? 351 HIS A CD2 1 
ATOM   2672 C  CE1 . HIS A 1 351 ? 43.948 -6.252  48.166  1.00 56.12 ? 351 HIS A CE1 1 
ATOM   2673 N  NE2 . HIS A 1 351 ? 43.408 -5.956  49.352  1.00 54.63 ? 351 HIS A NE2 1 
ATOM   2674 N  N   . HIS A 1 352 ? 38.310 -9.792  46.700  1.00 44.42 ? 352 HIS A N   1 
ATOM   2675 C  CA  A HIS A 1 352 ? 36.925 -10.168 46.292  0.70 46.30 ? 352 HIS A CA  1 
ATOM   2676 C  CA  B HIS A 1 352 ? 36.925 -10.165 46.299  0.30 46.41 ? 352 HIS A CA  1 
ATOM   2677 C  C   . HIS A 1 352 ? 36.500 -11.583 46.764  1.00 45.57 ? 352 HIS A C   1 
ATOM   2678 O  O   . HIS A 1 352 ? 37.153 -12.713 46.604  1.00 49.56 ? 352 HIS A O   1 
ATOM   2679 C  CB  A HIS A 1 352 ? 36.751 -10.063 44.772  0.70 47.98 ? 352 HIS A CB  1 
ATOM   2680 C  CB  B HIS A 1 352 ? 36.762 -10.008 44.782  0.30 47.93 ? 352 HIS A CB  1 
ATOM   2681 C  CG  A HIS A 1 352 ? 36.852 -8.678  44.233  0.70 49.65 ? 352 HIS A CG  1 
ATOM   2682 C  CG  B HIS A 1 352 ? 35.339 -9.915  44.350  0.30 46.86 ? 352 HIS A CG  1 
ATOM   2683 N  ND1 A HIS A 1 352 ? 38.048 -7.998  44.164  0.70 53.14 ? 352 HIS A ND1 1 
ATOM   2684 N  ND1 B HIS A 1 352 ? 34.475 -10.988 44.425  0.30 45.81 ? 352 HIS A ND1 1 
ATOM   2685 C  CD2 A HIS A 1 352 ? 35.916 -7.850  43.722  0.70 50.99 ? 352 HIS A CD2 1 
ATOM   2686 C  CD2 B HIS A 1 352 ? 34.625 -8.884  43.851  0.30 46.90 ? 352 HIS A CD2 1 
ATOM   2687 C  CE1 A HIS A 1 352 ? 37.848 -6.806  43.644  0.70 50.82 ? 352 HIS A CE1 1 
ATOM   2688 C  CE1 B HIS A 1 352 ? 33.288 -10.624 43.986  0.30 47.69 ? 352 HIS A CE1 1 
ATOM   2689 N  NE2 A HIS A 1 352 ? 36.548 -6.691  43.363  0.70 51.91 ? 352 HIS A NE2 1 
ATOM   2690 N  NE2 B HIS A 1 352 ? 33.353 -9.337  43.628  0.30 47.74 ? 352 HIS A NE2 1 
ATOM   2691 N  N   . HIS A 1 353 ? 35.378 -11.609 47.480  1.00 41.88 ? 353 HIS A N   1 
ATOM   2692 C  CA  . HIS A 1 353 ? 34.872 -12.915 47.975  1.00 46.07 ? 353 HIS A CA  1 
ATOM   2693 C  C   . HIS A 1 353 ? 33.613 -13.315 47.197  1.00 43.08 ? 353 HIS A C   1 
ATOM   2694 O  O   . HIS A 1 353 ? 32.523 -13.112 47.730  1.00 44.46 ? 353 HIS A O   1 
ATOM   2695 C  CB  . HIS A 1 353 ? 34.649 -12.863 49.488  1.00 44.42 ? 353 HIS A CB  1 
ATOM   2696 C  CG  . HIS A 1 353 ? 34.383 -14.192 50.109  1.00 41.03 ? 353 HIS A CG  1 
ATOM   2697 N  ND1 . HIS A 1 353 ? 34.066 -14.330 51.441  1.00 33.13 ? 353 HIS A ND1 1 
ATOM   2698 C  CD2 . HIS A 1 353 ? 34.385 -15.437 49.589  1.00 40.43 ? 353 HIS A CD2 1 
ATOM   2699 C  CE1 . HIS A 1 353 ? 33.883 -15.603 51.716  1.00 42.88 ? 353 HIS A CE1 1 
ATOM   2700 N  NE2 . HIS A 1 353 ? 34.073 -16.303 50.597  1.00 39.33 ? 353 HIS A NE2 1 
HETATM 2701 ZN ZN  . ZN  B 2 .   ? 37.519 -20.111 1.747   1.00 37.67 ? 401 ZN  A ZN  1 
HETATM 2702 O  O   . HOH C 3 .   ? 41.011 -8.180  3.192   1.00 39.77 ? 501 HOH A O   1 
HETATM 2703 O  O   . HOH C 3 .   ? 47.307 -29.458 5.292   1.00 41.59 ? 502 HOH A O   1 
HETATM 2704 O  O   . HOH C 3 .   ? 34.756 -26.746 11.344  1.00 41.37 ? 503 HOH A O   1 
HETATM 2705 O  O   . HOH C 3 .   ? 50.726 -32.381 11.782  1.00 31.79 ? 504 HOH A O   1 
HETATM 2706 O  O   . HOH C 3 .   ? 49.883 -15.499 -4.709  1.00 40.54 ? 505 HOH A O   1 
HETATM 2707 O  O   . HOH C 3 .   ? 33.568 -21.212 3.570   1.00 42.26 ? 506 HOH A O   1 
HETATM 2708 O  O   . HOH C 3 .   ? 34.341 -6.409  1.251   1.00 45.03 ? 507 HOH A O   1 
HETATM 2709 O  O   . HOH C 3 .   ? 42.274 -19.416 8.197   1.00 34.32 ? 508 HOH A O   1 
HETATM 2710 O  O   . HOH C 3 .   ? 37.941 -14.121 -3.598  1.00 43.84 ? 509 HOH A O   1 
HETATM 2711 O  O   . HOH C 3 .   ? 47.318 -15.247 2.368   1.00 35.82 ? 510 HOH A O   1 
HETATM 2712 O  O   . HOH C 3 .   ? 33.171 -11.291 0.930   1.00 41.99 ? 511 HOH A O   1 
HETATM 2713 O  O   . HOH C 3 .   ? 44.089 -19.667 6.149   1.00 34.19 ? 512 HOH A O   1 
HETATM 2714 O  O   . HOH C 3 .   ? 38.791 -5.596  -4.218  1.00 43.86 ? 513 HOH A O   1 
HETATM 2715 O  O   . HOH C 3 .   ? 38.789 -12.290 -1.822  1.00 40.18 ? 514 HOH A O   1 
HETATM 2716 O  O   . HOH C 3 .   ? 34.249 -32.702 8.764   1.00 50.98 ? 515 HOH A O   1 
HETATM 2717 O  O   . HOH C 3 .   ? 51.219 -8.343  2.251   1.00 42.08 ? 516 HOH A O   1 
HETATM 2718 O  O   . HOH C 3 .   ? 62.865 -13.156 17.081  1.00 43.13 ? 517 HOH A O   1 
HETATM 2719 O  O   . HOH C 3 .   ? 41.730 -32.267 8.624   1.00 34.27 ? 518 HOH A O   1 
HETATM 2720 O  O   . HOH C 3 .   ? 38.199 -14.631 7.166   1.00 35.25 ? 519 HOH A O   1 
HETATM 2721 O  O   . HOH C 3 .   ? 58.795 -26.119 17.868  1.00 42.43 ? 520 HOH A O   1 
HETATM 2722 O  O   . HOH C 3 .   ? 34.759 -26.620 14.041  1.00 46.17 ? 521 HOH A O   1 
HETATM 2723 O  O   . HOH C 3 .   ? 36.518 -16.476 2.875   1.00 36.73 ? 522 HOH A O   1 
HETATM 2724 O  O   . HOH C 3 .   ? 49.067 -32.358 25.966  1.00 39.19 ? 523 HOH A O   1 
HETATM 2725 O  O   . HOH C 3 .   ? 43.319 -5.548  1.560   1.00 43.59 ? 524 HOH A O   1 
HETATM 2726 O  O   . HOH C 3 .   ? 41.489 -12.885 -1.143  1.00 37.48 ? 525 HOH A O   1 
HETATM 2727 O  O   . HOH C 3 .   ? 48.440 -6.601  27.434  1.00 42.21 ? 526 HOH A O   1 
HETATM 2728 O  O   . HOH C 3 .   ? 43.305 -2.728  2.159   1.00 45.35 ? 527 HOH A O   1 
HETATM 2729 O  O   . HOH C 3 .   ? 48.817 -30.517 10.654  1.00 37.65 ? 528 HOH A O   1 
HETATM 2730 O  O   . HOH C 3 .   ? 43.526 -20.626 -8.249  1.00 53.84 ? 529 HOH A O   1 
HETATM 2731 O  O   . HOH C 3 .   ? 32.932 -3.683  1.603   1.00 48.00 ? 530 HOH A O   1 
# 
