data_8VNX
# 
_entry.id   8VNX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.400 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8VNX         pdb_00008vnx 10.2210/pdb8vnx/pdb 
WWPDB D_1000280612 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8VNX 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-13 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yxf423@med.miami.edu 
_pdbx_contact_author.name_first         Yangbo 
_pdbx_contact_author.name_last          Feng 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5894-9476 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Park, H.' 1 ? 
'Feng, Y.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Park, H.' 1 ? 
primary 'Feng, Y.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Mitogen-activated protein kinase 10'                                                                     
52649.332 1   2.7.11.24 ? ? ? 
2 non-polymer syn '(4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide' 
444.910   1   ?         ? ? ? 
3 water       nat water                                                                                                     18.015 
133 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCA
AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME
LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA
DSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN
SEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCA
AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME
LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA
DSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN
SEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '(4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide' WHQ 
3 water                                                                                                     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   LEU n 
1 4   HIS n 
1 5   PHE n 
1 6   LEU n 
1 7   TYR n 
1 8   TYR n 
1 9   CYS n 
1 10  SER n 
1 11  GLU n 
1 12  PRO n 
1 13  THR n 
1 14  LEU n 
1 15  ASP n 
1 16  VAL n 
1 17  LYS n 
1 18  ILE n 
1 19  ALA n 
1 20  PHE n 
1 21  CYS n 
1 22  GLN n 
1 23  GLY n 
1 24  PHE n 
1 25  ASP n 
1 26  LYS n 
1 27  GLN n 
1 28  VAL n 
1 29  ASP n 
1 30  VAL n 
1 31  SER n 
1 32  TYR n 
1 33  ILE n 
1 34  ALA n 
1 35  LYS n 
1 36  HIS n 
1 37  TYR n 
1 38  ASN n 
1 39  MET n 
1 40  SER n 
1 41  LYS n 
1 42  SER n 
1 43  LYS n 
1 44  VAL n 
1 45  ASP n 
1 46  ASN n 
1 47  GLN n 
1 48  PHE n 
1 49  TYR n 
1 50  SER n 
1 51  VAL n 
1 52  GLU n 
1 53  VAL n 
1 54  GLY n 
1 55  ASP n 
1 56  SER n 
1 57  THR n 
1 58  PHE n 
1 59  THR n 
1 60  VAL n 
1 61  LEU n 
1 62  LYS n 
1 63  ARG n 
1 64  TYR n 
1 65  GLN n 
1 66  ASN n 
1 67  LEU n 
1 68  LYS n 
1 69  PRO n 
1 70  ILE n 
1 71  GLY n 
1 72  SER n 
1 73  GLY n 
1 74  ALA n 
1 75  GLN n 
1 76  GLY n 
1 77  ILE n 
1 78  VAL n 
1 79  CYS n 
1 80  ALA n 
1 81  ALA n 
1 82  TYR n 
1 83  ASP n 
1 84  ALA n 
1 85  VAL n 
1 86  LEU n 
1 87  ASP n 
1 88  ARG n 
1 89  ASN n 
1 90  VAL n 
1 91  ALA n 
1 92  ILE n 
1 93  LYS n 
1 94  LYS n 
1 95  LEU n 
1 96  SER n 
1 97  ARG n 
1 98  PRO n 
1 99  PHE n 
1 100 GLN n 
1 101 ASN n 
1 102 GLN n 
1 103 THR n 
1 104 HIS n 
1 105 ALA n 
1 106 LYS n 
1 107 ARG n 
1 108 ALA n 
1 109 TYR n 
1 110 ARG n 
1 111 GLU n 
1 112 LEU n 
1 113 VAL n 
1 114 LEU n 
1 115 MET n 
1 116 LYS n 
1 117 CYS n 
1 118 VAL n 
1 119 ASN n 
1 120 HIS n 
1 121 LYS n 
1 122 ASN n 
1 123 ILE n 
1 124 ILE n 
1 125 SER n 
1 126 LEU n 
1 127 LEU n 
1 128 ASN n 
1 129 VAL n 
1 130 PHE n 
1 131 THR n 
1 132 PRO n 
1 133 GLN n 
1 134 LYS n 
1 135 THR n 
1 136 LEU n 
1 137 GLU n 
1 138 GLU n 
1 139 PHE n 
1 140 GLN n 
1 141 ASP n 
1 142 VAL n 
1 143 TYR n 
1 144 LEU n 
1 145 VAL n 
1 146 MET n 
1 147 GLU n 
1 148 LEU n 
1 149 MET n 
1 150 ASP n 
1 151 ALA n 
1 152 ASN n 
1 153 LEU n 
1 154 CYS n 
1 155 GLN n 
1 156 VAL n 
1 157 ILE n 
1 158 GLN n 
1 159 MET n 
1 160 GLU n 
1 161 LEU n 
1 162 ASP n 
1 163 HIS n 
1 164 GLU n 
1 165 ARG n 
1 166 MET n 
1 167 SER n 
1 168 TYR n 
1 169 LEU n 
1 170 LEU n 
1 171 TYR n 
1 172 GLN n 
1 173 MET n 
1 174 LEU n 
1 175 CYS n 
1 176 GLY n 
1 177 ILE n 
1 178 LYS n 
1 179 HIS n 
1 180 LEU n 
1 181 HIS n 
1 182 SER n 
1 183 ALA n 
1 184 GLY n 
1 185 ILE n 
1 186 ILE n 
1 187 HIS n 
1 188 ARG n 
1 189 ASP n 
1 190 LEU n 
1 191 LYS n 
1 192 PRO n 
1 193 SER n 
1 194 ASN n 
1 195 ILE n 
1 196 VAL n 
1 197 VAL n 
1 198 LYS n 
1 199 SER n 
1 200 ASP n 
1 201 CYS n 
1 202 THR n 
1 203 LEU n 
1 204 LYS n 
1 205 ILE n 
1 206 LEU n 
1 207 ASP n 
1 208 PHE n 
1 209 GLY n 
1 210 LEU n 
1 211 ALA n 
1 212 ARG n 
1 213 THR n 
1 214 ALA n 
1 215 GLY n 
1 216 THR n 
1 217 SER n 
1 218 PHE n 
1 219 MET n 
1 220 MET n 
1 221 THR n 
1 222 PRO n 
1 223 TYR n 
1 224 VAL n 
1 225 VAL n 
1 226 THR n 
1 227 ARG n 
1 228 TYR n 
1 229 TYR n 
1 230 ARG n 
1 231 ALA n 
1 232 PRO n 
1 233 GLU n 
1 234 VAL n 
1 235 ILE n 
1 236 LEU n 
1 237 GLY n 
1 238 MET n 
1 239 GLY n 
1 240 TYR n 
1 241 LYS n 
1 242 GLU n 
1 243 ASN n 
1 244 VAL n 
1 245 ASP n 
1 246 ILE n 
1 247 TRP n 
1 248 SER n 
1 249 VAL n 
1 250 GLY n 
1 251 CYS n 
1 252 ILE n 
1 253 MET n 
1 254 GLY n 
1 255 GLU n 
1 256 MET n 
1 257 VAL n 
1 258 ARG n 
1 259 HIS n 
1 260 LYS n 
1 261 ILE n 
1 262 LEU n 
1 263 PHE n 
1 264 PRO n 
1 265 GLY n 
1 266 ARG n 
1 267 ASP n 
1 268 TYR n 
1 269 ILE n 
1 270 ASP n 
1 271 GLN n 
1 272 TRP n 
1 273 ASN n 
1 274 LYS n 
1 275 VAL n 
1 276 ILE n 
1 277 GLU n 
1 278 GLN n 
1 279 LEU n 
1 280 GLY n 
1 281 THR n 
1 282 PRO n 
1 283 CYS n 
1 284 PRO n 
1 285 GLU n 
1 286 PHE n 
1 287 MET n 
1 288 LYS n 
1 289 LYS n 
1 290 LEU n 
1 291 GLN n 
1 292 PRO n 
1 293 THR n 
1 294 VAL n 
1 295 ARG n 
1 296 ASN n 
1 297 TYR n 
1 298 VAL n 
1 299 GLU n 
1 300 ASN n 
1 301 ARG n 
1 302 PRO n 
1 303 LYS n 
1 304 TYR n 
1 305 ALA n 
1 306 GLY n 
1 307 LEU n 
1 308 THR n 
1 309 PHE n 
1 310 PRO n 
1 311 LYS n 
1 312 LEU n 
1 313 PHE n 
1 314 PRO n 
1 315 ASP n 
1 316 SER n 
1 317 LEU n 
1 318 PHE n 
1 319 PRO n 
1 320 ALA n 
1 321 ASP n 
1 322 SER n 
1 323 GLU n 
1 324 HIS n 
1 325 ASN n 
1 326 LYS n 
1 327 LEU n 
1 328 LYS n 
1 329 ALA n 
1 330 SER n 
1 331 GLN n 
1 332 ALA n 
1 333 ARG n 
1 334 ASP n 
1 335 LEU n 
1 336 LEU n 
1 337 SER n 
1 338 LYS n 
1 339 MET n 
1 340 LEU n 
1 341 VAL n 
1 342 ILE n 
1 343 ASP n 
1 344 PRO n 
1 345 ALA n 
1 346 LYS n 
1 347 ARG n 
1 348 ILE n 
1 349 SER n 
1 350 VAL n 
1 351 ASP n 
1 352 ASP n 
1 353 ALA n 
1 354 LEU n 
1 355 GLN n 
1 356 HIS n 
1 357 PRO n 
1 358 TYR n 
1 359 ILE n 
1 360 ASN n 
1 361 VAL n 
1 362 TRP n 
1 363 TYR n 
1 364 ASP n 
1 365 PRO n 
1 366 ALA n 
1 367 GLU n 
1 368 VAL n 
1 369 GLU n 
1 370 ALA n 
1 371 PRO n 
1 372 PRO n 
1 373 PRO n 
1 374 GLN n 
1 375 ILE n 
1 376 TYR n 
1 377 ASP n 
1 378 LYS n 
1 379 GLN n 
1 380 LEU n 
1 381 ASP n 
1 382 GLU n 
1 383 ARG n 
1 384 GLU n 
1 385 HIS n 
1 386 THR n 
1 387 ILE n 
1 388 GLU n 
1 389 GLU n 
1 390 TRP n 
1 391 LYS n 
1 392 GLU n 
1 393 LEU n 
1 394 ILE n 
1 395 TYR n 
1 396 LYS n 
1 397 GLU n 
1 398 VAL n 
1 399 MET n 
1 400 ASN n 
1 401 SER n 
1 402 GLU n 
1 403 GLU n 
1 404 LYS n 
1 405 THR n 
1 406 LYS n 
1 407 ASN n 
1 408 GLY n 
1 409 VAL n 
1 410 VAL n 
1 411 LYS n 
1 412 GLY n 
1 413 GLN n 
1 414 PRO n 
1 415 SER n 
1 416 PRO n 
1 417 SER n 
1 418 GLY n 
1 419 ALA n 
1 420 ALA n 
1 421 VAL n 
1 422 ASN n 
1 423 SER n 
1 424 SER n 
1 425 GLU n 
1 426 SER n 
1 427 LEU n 
1 428 PRO n 
1 429 PRO n 
1 430 SER n 
1 431 SER n 
1 432 SER n 
1 433 VAL n 
1 434 ASN n 
1 435 ASP n 
1 436 ILE n 
1 437 SER n 
1 438 SER n 
1 439 MET n 
1 440 SER n 
1 441 THR n 
1 442 ASP n 
1 443 GLN n 
1 444 THR n 
1 445 LEU n 
1 446 ALA n 
1 447 SER n 
1 448 ASP n 
1 449 THR n 
1 450 ASP n 
1 451 SER n 
1 452 SER n 
1 453 LEU n 
1 454 GLU n 
1 455 ALA n 
1 456 SER n 
1 457 ALA n 
1 458 GLY n 
1 459 PRO n 
1 460 LEU n 
1 461 GLY n 
1 462 CYS n 
1 463 CYS n 
1 464 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   464 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'MAPK10, JNK3, JNK3A, PRKM10, SAPK1B' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'           89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'       175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'          132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'           133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'         121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'         146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'           147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'           75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'       156.162 
HOH non-polymer         . WATER ? 'H2 O'                 18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'          131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'          131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'       147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'        149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'          165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'           115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'           105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'           119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'        204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'          181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'          117.146 
WHQ non-polymer         . 
'(4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide' ? 'C21 H18 Cl F N4 O2 S' 
444.910 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   LEU 3   3   ?   ?   ?   A . n 
A 1 4   HIS 4   4   ?   ?   ?   A . n 
A 1 5   PHE 5   5   ?   ?   ?   A . n 
A 1 6   LEU 6   6   ?   ?   ?   A . n 
A 1 7   TYR 7   7   ?   ?   ?   A . n 
A 1 8   TYR 8   8   ?   ?   ?   A . n 
A 1 9   CYS 9   9   ?   ?   ?   A . n 
A 1 10  SER 10  10  ?   ?   ?   A . n 
A 1 11  GLU 11  11  ?   ?   ?   A . n 
A 1 12  PRO 12  12  ?   ?   ?   A . n 
A 1 13  THR 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  ASP 15  15  ?   ?   ?   A . n 
A 1 16  VAL 16  16  ?   ?   ?   A . n 
A 1 17  LYS 17  17  ?   ?   ?   A . n 
A 1 18  ILE 18  18  ?   ?   ?   A . n 
A 1 19  ALA 19  19  ?   ?   ?   A . n 
A 1 20  PHE 20  20  ?   ?   ?   A . n 
A 1 21  CYS 21  21  ?   ?   ?   A . n 
A 1 22  GLN 22  22  ?   ?   ?   A . n 
A 1 23  GLY 23  23  ?   ?   ?   A . n 
A 1 24  PHE 24  24  ?   ?   ?   A . n 
A 1 25  ASP 25  25  ?   ?   ?   A . n 
A 1 26  LYS 26  26  ?   ?   ?   A . n 
A 1 27  GLN 27  27  ?   ?   ?   A . n 
A 1 28  VAL 28  28  ?   ?   ?   A . n 
A 1 29  ASP 29  29  ?   ?   ?   A . n 
A 1 30  VAL 30  30  ?   ?   ?   A . n 
A 1 31  SER 31  31  ?   ?   ?   A . n 
A 1 32  TYR 32  32  ?   ?   ?   A . n 
A 1 33  ILE 33  33  ?   ?   ?   A . n 
A 1 34  ALA 34  34  ?   ?   ?   A . n 
A 1 35  LYS 35  35  ?   ?   ?   A . n 
A 1 36  HIS 36  36  ?   ?   ?   A . n 
A 1 37  TYR 37  37  ?   ?   ?   A . n 
A 1 38  ASN 38  38  ?   ?   ?   A . n 
A 1 39  MET 39  39  ?   ?   ?   A . n 
A 1 40  SER 40  40  ?   ?   ?   A . n 
A 1 41  LYS 41  41  ?   ?   ?   A . n 
A 1 42  SER 42  42  ?   ?   ?   A . n 
A 1 43  LYS 43  43  ?   ?   ?   A . n 
A 1 44  VAL 44  44  ?   ?   ?   A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  ASN 46  46  46  ASN ASN A . n 
A 1 47  GLN 47  47  47  GLN GLN A . n 
A 1 48  PHE 48  48  48  PHE PHE A . n 
A 1 49  TYR 49  49  49  TYR TYR A . n 
A 1 50  SER 50  50  50  SER SER A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  GLU 52  52  52  GLU GLU A . n 
A 1 53  VAL 53  53  53  VAL VAL A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  SER 56  56  56  SER SER A . n 
A 1 57  THR 57  57  57  THR THR A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  THR 59  59  59  THR THR A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  ARG 63  63  63  ARG ARG A . n 
A 1 64  TYR 64  64  64  TYR TYR A . n 
A 1 65  GLN 65  65  65  GLN GLN A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  LYS 68  68  68  LYS LYS A . n 
A 1 69  PRO 69  69  69  PRO PRO A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  SER 72  72  72  SER SER A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  GLN 75  75  75  GLN GLN A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  ILE 77  77  77  ILE ILE A . n 
A 1 78  VAL 78  78  78  VAL VAL A . n 
A 1 79  CYS 79  79  79  CYS CYS A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  ALA 81  81  81  ALA ALA A . n 
A 1 82  TYR 82  82  82  TYR TYR A . n 
A 1 83  ASP 83  83  83  ASP ASP A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  VAL 85  85  85  VAL VAL A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  ARG 88  88  88  ARG ARG A . n 
A 1 89  ASN 89  89  89  ASN ASN A . n 
A 1 90  VAL 90  90  90  VAL VAL A . n 
A 1 91  ALA 91  91  91  ALA ALA A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  LYS 93  93  93  LYS LYS A . n 
A 1 94  LYS 94  94  94  LYS LYS A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  SER 96  96  96  SER SER A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  PRO 98  98  98  PRO PRO A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 GLN 100 100 100 GLN GLN A . n 
A 1 101 ASN 101 101 101 ASN ASN A . n 
A 1 102 GLN 102 102 102 GLN GLN A . n 
A 1 103 THR 103 103 103 THR THR A . n 
A 1 104 HIS 104 104 104 HIS HIS A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ARG 107 107 107 ARG ARG A . n 
A 1 108 ALA 108 108 108 ALA ALA A . n 
A 1 109 TYR 109 109 109 TYR TYR A . n 
A 1 110 ARG 110 110 110 ARG ARG A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 VAL 113 113 113 VAL VAL A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 MET 115 115 115 MET MET A . n 
A 1 116 LYS 116 116 116 LYS LYS A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 VAL 118 118 118 VAL VAL A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 HIS 120 120 120 HIS HIS A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 ASN 122 122 122 ASN ASN A . n 
A 1 123 ILE 123 123 123 ILE ILE A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 SER 125 125 125 SER SER A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 LEU 127 127 127 LEU LEU A . n 
A 1 128 ASN 128 128 128 ASN ASN A . n 
A 1 129 VAL 129 129 129 VAL VAL A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 THR 131 131 131 THR THR A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 GLN 133 133 133 GLN GLN A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 GLN 140 140 140 GLN GLN A . n 
A 1 141 ASP 141 141 141 ASP ASP A . n 
A 1 142 VAL 142 142 142 VAL VAL A . n 
A 1 143 TYR 143 143 143 TYR TYR A . n 
A 1 144 LEU 144 144 144 LEU LEU A . n 
A 1 145 VAL 145 145 145 VAL VAL A . n 
A 1 146 MET 146 146 146 MET MET A . n 
A 1 147 GLU 147 147 147 GLU GLU A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 MET 149 149 149 MET MET A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 CYS 154 154 154 CYS CYS A . n 
A 1 155 GLN 155 155 155 GLN GLN A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 GLN 158 158 158 GLN GLN A . n 
A 1 159 MET 159 159 159 MET MET A . n 
A 1 160 GLU 160 160 160 GLU GLU A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 GLU 164 164 164 GLU GLU A . n 
A 1 165 ARG 165 165 165 ARG ARG A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 SER 167 167 167 SER SER A . n 
A 1 168 TYR 168 168 168 TYR TYR A . n 
A 1 169 LEU 169 169 169 LEU LEU A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 TYR 171 171 171 TYR TYR A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 MET 173 173 173 MET MET A . n 
A 1 174 LEU 174 174 174 LEU LEU A . n 
A 1 175 CYS 175 175 175 CYS CYS A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 ILE 177 177 177 ILE ILE A . n 
A 1 178 LYS 178 178 178 LYS LYS A . n 
A 1 179 HIS 179 179 179 HIS HIS A . n 
A 1 180 LEU 180 180 180 LEU LEU A . n 
A 1 181 HIS 181 181 181 HIS HIS A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 GLY 184 184 184 GLY GLY A . n 
A 1 185 ILE 185 185 185 ILE ILE A . n 
A 1 186 ILE 186 186 186 ILE ILE A . n 
A 1 187 HIS 187 187 187 HIS HIS A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 ASP 189 189 189 ASP ASP A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 PRO 192 192 192 PRO PRO A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 ASN 194 194 194 ASN ASN A . n 
A 1 195 ILE 195 195 195 ILE ILE A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 LYS 198 198 198 LYS LYS A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 ASP 200 200 200 ASP ASP A . n 
A 1 201 CYS 201 201 201 CYS CYS A . n 
A 1 202 THR 202 202 202 THR THR A . n 
A 1 203 LEU 203 203 203 LEU LEU A . n 
A 1 204 LYS 204 204 204 LYS LYS A . n 
A 1 205 ILE 205 205 205 ILE ILE A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 ASP 207 207 207 ASP ASP A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 GLY 209 209 209 GLY GLY A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 ARG 212 212 ?   ?   ?   A . n 
A 1 213 THR 213 213 ?   ?   ?   A . n 
A 1 214 ALA 214 214 ?   ?   ?   A . n 
A 1 215 GLY 215 215 ?   ?   ?   A . n 
A 1 216 THR 216 216 ?   ?   ?   A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 PHE 218 218 218 PHE PHE A . n 
A 1 219 MET 219 219 219 MET MET A . n 
A 1 220 MET 220 220 220 MET MET A . n 
A 1 221 THR 221 221 221 THR THR A . n 
A 1 222 PRO 222 222 222 PRO PRO A . n 
A 1 223 TYR 223 223 223 TYR TYR A . n 
A 1 224 VAL 224 224 224 VAL VAL A . n 
A 1 225 VAL 225 225 225 VAL VAL A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 ARG 227 227 227 ARG ARG A . n 
A 1 228 TYR 228 228 228 TYR TYR A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 ARG 230 230 230 ARG ARG A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 PRO 232 232 232 PRO PRO A . n 
A 1 233 GLU 233 233 233 GLU GLU A . n 
A 1 234 VAL 234 234 234 VAL VAL A . n 
A 1 235 ILE 235 235 235 ILE ILE A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 MET 238 238 238 MET MET A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 TYR 240 240 240 TYR TYR A . n 
A 1 241 LYS 241 241 241 LYS LYS A . n 
A 1 242 GLU 242 242 242 GLU GLU A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 ILE 246 246 246 ILE ILE A . n 
A 1 247 TRP 247 247 247 TRP TRP A . n 
A 1 248 SER 248 248 248 SER SER A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 GLY 250 250 250 GLY GLY A . n 
A 1 251 CYS 251 251 251 CYS CYS A . n 
A 1 252 ILE 252 252 252 ILE ILE A . n 
A 1 253 MET 253 253 253 MET MET A . n 
A 1 254 GLY 254 254 254 GLY GLY A . n 
A 1 255 GLU 255 255 255 GLU GLU A . n 
A 1 256 MET 256 256 256 MET MET A . n 
A 1 257 VAL 257 257 257 VAL VAL A . n 
A 1 258 ARG 258 258 258 ARG ARG A . n 
A 1 259 HIS 259 259 259 HIS HIS A . n 
A 1 260 LYS 260 260 260 LYS LYS A . n 
A 1 261 ILE 261 261 261 ILE ILE A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 PHE 263 263 263 PHE PHE A . n 
A 1 264 PRO 264 264 264 PRO PRO A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 ARG 266 266 266 ARG ARG A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 TYR 268 268 268 TYR TYR A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 ASP 270 270 270 ASP ASP A . n 
A 1 271 GLN 271 271 271 GLN GLN A . n 
A 1 272 TRP 272 272 272 TRP TRP A . n 
A 1 273 ASN 273 273 273 ASN ASN A . n 
A 1 274 LYS 274 274 274 LYS LYS A . n 
A 1 275 VAL 275 275 275 VAL VAL A . n 
A 1 276 ILE 276 276 276 ILE ILE A . n 
A 1 277 GLU 277 277 277 GLU GLU A . n 
A 1 278 GLN 278 278 278 GLN GLN A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 THR 281 281 281 THR THR A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 CYS 283 283 283 CYS CYS A . n 
A 1 284 PRO 284 284 284 PRO PRO A . n 
A 1 285 GLU 285 285 285 GLU GLU A . n 
A 1 286 PHE 286 286 286 PHE PHE A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 LYS 289 289 289 LYS LYS A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 GLN 291 291 291 GLN GLN A . n 
A 1 292 PRO 292 292 292 PRO PRO A . n 
A 1 293 THR 293 293 293 THR THR A . n 
A 1 294 VAL 294 294 294 VAL VAL A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 ASN 296 296 296 ASN ASN A . n 
A 1 297 TYR 297 297 297 TYR TYR A . n 
A 1 298 VAL 298 298 298 VAL VAL A . n 
A 1 299 GLU 299 299 299 GLU GLU A . n 
A 1 300 ASN 300 300 300 ASN ASN A . n 
A 1 301 ARG 301 301 301 ARG ARG A . n 
A 1 302 PRO 302 302 302 PRO PRO A . n 
A 1 303 LYS 303 303 303 LYS LYS A . n 
A 1 304 TYR 304 304 304 TYR TYR A . n 
A 1 305 ALA 305 305 305 ALA ALA A . n 
A 1 306 GLY 306 306 306 GLY GLY A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 THR 308 308 308 THR THR A . n 
A 1 309 PHE 309 309 309 PHE PHE A . n 
A 1 310 PRO 310 310 310 PRO PRO A . n 
A 1 311 LYS 311 311 311 LYS LYS A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 PHE 313 313 313 PHE PHE A . n 
A 1 314 PRO 314 314 314 PRO PRO A . n 
A 1 315 ASP 315 315 315 ASP ASP A . n 
A 1 316 SER 316 316 316 SER SER A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 PHE 318 318 318 PHE PHE A . n 
A 1 319 PRO 319 319 319 PRO PRO A . n 
A 1 320 ALA 320 320 320 ALA ALA A . n 
A 1 321 ASP 321 321 321 ASP ASP A . n 
A 1 322 SER 322 322 322 SER SER A . n 
A 1 323 GLU 323 323 323 GLU GLU A . n 
A 1 324 HIS 324 324 324 HIS HIS A . n 
A 1 325 ASN 325 325 325 ASN ASN A . n 
A 1 326 LYS 326 326 326 LYS LYS A . n 
A 1 327 LEU 327 327 327 LEU LEU A . n 
A 1 328 LYS 328 328 328 LYS LYS A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 SER 330 330 330 SER SER A . n 
A 1 331 GLN 331 331 331 GLN GLN A . n 
A 1 332 ALA 332 332 332 ALA ALA A . n 
A 1 333 ARG 333 333 333 ARG ARG A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 LEU 335 335 335 LEU LEU A . n 
A 1 336 LEU 336 336 336 LEU LEU A . n 
A 1 337 SER 337 337 337 SER SER A . n 
A 1 338 LYS 338 338 338 LYS LYS A . n 
A 1 339 MET 339 339 339 MET MET A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ILE 342 342 342 ILE ILE A . n 
A 1 343 ASP 343 343 343 ASP ASP A . n 
A 1 344 PRO 344 344 344 PRO PRO A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 LYS 346 346 346 LYS LYS A . n 
A 1 347 ARG 347 347 347 ARG ARG A . n 
A 1 348 ILE 348 348 348 ILE ILE A . n 
A 1 349 SER 349 349 349 SER SER A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 ASP 351 351 351 ASP ASP A . n 
A 1 352 ASP 352 352 352 ASP ASP A . n 
A 1 353 ALA 353 353 353 ALA ALA A . n 
A 1 354 LEU 354 354 354 LEU LEU A . n 
A 1 355 GLN 355 355 355 GLN GLN A . n 
A 1 356 HIS 356 356 356 HIS HIS A . n 
A 1 357 PRO 357 357 357 PRO PRO A . n 
A 1 358 TYR 358 358 358 TYR TYR A . n 
A 1 359 ILE 359 359 359 ILE ILE A . n 
A 1 360 ASN 360 360 360 ASN ASN A . n 
A 1 361 VAL 361 361 361 VAL VAL A . n 
A 1 362 TRP 362 362 362 TRP TRP A . n 
A 1 363 TYR 363 363 363 TYR TYR A . n 
A 1 364 ASP 364 364 364 ASP ASP A . n 
A 1 365 PRO 365 365 365 PRO PRO A . n 
A 1 366 ALA 366 366 366 ALA ALA A . n 
A 1 367 GLU 367 367 367 GLU GLU A . n 
A 1 368 VAL 368 368 368 VAL VAL A . n 
A 1 369 GLU 369 369 369 GLU GLU A . n 
A 1 370 ALA 370 370 370 ALA ALA A . n 
A 1 371 PRO 371 371 371 PRO PRO A . n 
A 1 372 PRO 372 372 372 PRO PRO A . n 
A 1 373 PRO 373 373 373 PRO PRO A . n 
A 1 374 GLN 374 374 ?   ?   ?   A . n 
A 1 375 ILE 375 375 ?   ?   ?   A . n 
A 1 376 TYR 376 376 ?   ?   ?   A . n 
A 1 377 ASP 377 377 ?   ?   ?   A . n 
A 1 378 LYS 378 378 ?   ?   ?   A . n 
A 1 379 GLN 379 379 379 GLN GLN A . n 
A 1 380 LEU 380 380 380 LEU LEU A . n 
A 1 381 ASP 381 381 381 ASP ASP A . n 
A 1 382 GLU 382 382 382 GLU GLU A . n 
A 1 383 ARG 383 383 383 ARG ARG A . n 
A 1 384 GLU 384 384 384 GLU GLU A . n 
A 1 385 HIS 385 385 385 HIS HIS A . n 
A 1 386 THR 386 386 386 THR THR A . n 
A 1 387 ILE 387 387 387 ILE ILE A . n 
A 1 388 GLU 388 388 388 GLU GLU A . n 
A 1 389 GLU 389 389 389 GLU GLU A . n 
A 1 390 TRP 390 390 390 TRP TRP A . n 
A 1 391 LYS 391 391 391 LYS LYS A . n 
A 1 392 GLU 392 392 392 GLU GLU A . n 
A 1 393 LEU 393 393 393 LEU LEU A . n 
A 1 394 ILE 394 394 394 ILE ILE A . n 
A 1 395 TYR 395 395 395 TYR TYR A . n 
A 1 396 LYS 396 396 396 LYS LYS A . n 
A 1 397 GLU 397 397 397 GLU GLU A . n 
A 1 398 VAL 398 398 398 VAL VAL A . n 
A 1 399 MET 399 399 399 MET MET A . n 
A 1 400 ASN 400 400 400 ASN ASN A . n 
A 1 401 SER 401 401 ?   ?   ?   A . n 
A 1 402 GLU 402 402 ?   ?   ?   A . n 
A 1 403 GLU 403 403 ?   ?   ?   A . n 
A 1 404 LYS 404 404 ?   ?   ?   A . n 
A 1 405 THR 405 405 ?   ?   ?   A . n 
A 1 406 LYS 406 406 ?   ?   ?   A . n 
A 1 407 ASN 407 407 ?   ?   ?   A . n 
A 1 408 GLY 408 408 ?   ?   ?   A . n 
A 1 409 VAL 409 409 ?   ?   ?   A . n 
A 1 410 VAL 410 410 ?   ?   ?   A . n 
A 1 411 LYS 411 411 ?   ?   ?   A . n 
A 1 412 GLY 412 412 ?   ?   ?   A . n 
A 1 413 GLN 413 413 ?   ?   ?   A . n 
A 1 414 PRO 414 414 ?   ?   ?   A . n 
A 1 415 SER 415 415 ?   ?   ?   A . n 
A 1 416 PRO 416 416 ?   ?   ?   A . n 
A 1 417 SER 417 417 ?   ?   ?   A . n 
A 1 418 GLY 418 418 ?   ?   ?   A . n 
A 1 419 ALA 419 419 ?   ?   ?   A . n 
A 1 420 ALA 420 420 ?   ?   ?   A . n 
A 1 421 VAL 421 421 ?   ?   ?   A . n 
A 1 422 ASN 422 422 ?   ?   ?   A . n 
A 1 423 SER 423 423 ?   ?   ?   A . n 
A 1 424 SER 424 424 ?   ?   ?   A . n 
A 1 425 GLU 425 425 ?   ?   ?   A . n 
A 1 426 SER 426 426 ?   ?   ?   A . n 
A 1 427 LEU 427 427 ?   ?   ?   A . n 
A 1 428 PRO 428 428 ?   ?   ?   A . n 
A 1 429 PRO 429 429 ?   ?   ?   A . n 
A 1 430 SER 430 430 ?   ?   ?   A . n 
A 1 431 SER 431 431 ?   ?   ?   A . n 
A 1 432 SER 432 432 ?   ?   ?   A . n 
A 1 433 VAL 433 433 ?   ?   ?   A . n 
A 1 434 ASN 434 434 ?   ?   ?   A . n 
A 1 435 ASP 435 435 ?   ?   ?   A . n 
A 1 436 ILE 436 436 ?   ?   ?   A . n 
A 1 437 SER 437 437 ?   ?   ?   A . n 
A 1 438 SER 438 438 ?   ?   ?   A . n 
A 1 439 MET 439 439 ?   ?   ?   A . n 
A 1 440 SER 440 440 ?   ?   ?   A . n 
A 1 441 THR 441 441 ?   ?   ?   A . n 
A 1 442 ASP 442 442 ?   ?   ?   A . n 
A 1 443 GLN 443 443 ?   ?   ?   A . n 
A 1 444 THR 444 444 ?   ?   ?   A . n 
A 1 445 LEU 445 445 ?   ?   ?   A . n 
A 1 446 ALA 446 446 ?   ?   ?   A . n 
A 1 447 SER 447 447 ?   ?   ?   A . n 
A 1 448 ASP 448 448 ?   ?   ?   A . n 
A 1 449 THR 449 449 ?   ?   ?   A . n 
A 1 450 ASP 450 450 ?   ?   ?   A . n 
A 1 451 SER 451 451 ?   ?   ?   A . n 
A 1 452 SER 452 452 ?   ?   ?   A . n 
A 1 453 LEU 453 453 ?   ?   ?   A . n 
A 1 454 GLU 454 454 ?   ?   ?   A . n 
A 1 455 ALA 455 455 ?   ?   ?   A . n 
A 1 456 SER 456 456 ?   ?   ?   A . n 
A 1 457 ALA 457 457 ?   ?   ?   A . n 
A 1 458 GLY 458 458 ?   ?   ?   A . n 
A 1 459 PRO 459 459 ?   ?   ?   A . n 
A 1 460 LEU 460 460 ?   ?   ?   A . n 
A 1 461 GLY 461 461 ?   ?   ?   A . n 
A 1 462 CYS 462 462 ?   ?   ?   A . n 
A 1 463 CYS 463 463 ?   ?   ?   A . n 
A 1 464 ARG 464 464 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        WHQ 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   WHQ 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 WHQ 1   501 501 WHQ 21J A . 
C 3 HOH 1   601 4   HOH HOH A . 
C 3 HOH 2   602 56  HOH HOH A . 
C 3 HOH 3   603 80  HOH HOH A . 
C 3 HOH 4   604 29  HOH HOH A . 
C 3 HOH 5   605 87  HOH HOH A . 
C 3 HOH 6   606 22  HOH HOH A . 
C 3 HOH 7   607 132 HOH HOH A . 
C 3 HOH 8   608 20  HOH HOH A . 
C 3 HOH 9   609 59  HOH HOH A . 
C 3 HOH 10  610 109 HOH HOH A . 
C 3 HOH 11  611 53  HOH HOH A . 
C 3 HOH 12  612 63  HOH HOH A . 
C 3 HOH 13  613 139 HOH HOH A . 
C 3 HOH 14  614 117 HOH HOH A . 
C 3 HOH 15  615 8   HOH HOH A . 
C 3 HOH 16  616 25  HOH HOH A . 
C 3 HOH 17  617 130 HOH HOH A . 
C 3 HOH 18  618 15  HOH HOH A . 
C 3 HOH 19  619 101 HOH HOH A . 
C 3 HOH 20  620 21  HOH HOH A . 
C 3 HOH 21  621 9   HOH HOH A . 
C 3 HOH 22  622 86  HOH HOH A . 
C 3 HOH 23  623 125 HOH HOH A . 
C 3 HOH 24  624 98  HOH HOH A . 
C 3 HOH 25  625 46  HOH HOH A . 
C 3 HOH 26  626 69  HOH HOH A . 
C 3 HOH 27  627 55  HOH HOH A . 
C 3 HOH 28  628 47  HOH HOH A . 
C 3 HOH 29  629 5   HOH HOH A . 
C 3 HOH 30  630 1   HOH HOH A . 
C 3 HOH 31  631 90  HOH HOH A . 
C 3 HOH 32  632 41  HOH HOH A . 
C 3 HOH 33  633 99  HOH HOH A . 
C 3 HOH 34  634 28  HOH HOH A . 
C 3 HOH 35  635 68  HOH HOH A . 
C 3 HOH 36  636 7   HOH HOH A . 
C 3 HOH 37  637 39  HOH HOH A . 
C 3 HOH 38  638 19  HOH HOH A . 
C 3 HOH 39  639 10  HOH HOH A . 
C 3 HOH 40  640 26  HOH HOH A . 
C 3 HOH 41  641 60  HOH HOH A . 
C 3 HOH 42  642 49  HOH HOH A . 
C 3 HOH 43  643 23  HOH HOH A . 
C 3 HOH 44  644 57  HOH HOH A . 
C 3 HOH 45  645 77  HOH HOH A . 
C 3 HOH 46  646 88  HOH HOH A . 
C 3 HOH 47  647 30  HOH HOH A . 
C 3 HOH 48  648 135 HOH HOH A . 
C 3 HOH 49  649 12  HOH HOH A . 
C 3 HOH 50  650 54  HOH HOH A . 
C 3 HOH 51  651 38  HOH HOH A . 
C 3 HOH 52  652 40  HOH HOH A . 
C 3 HOH 53  653 52  HOH HOH A . 
C 3 HOH 54  654 83  HOH HOH A . 
C 3 HOH 55  655 89  HOH HOH A . 
C 3 HOH 56  656 14  HOH HOH A . 
C 3 HOH 57  657 75  HOH HOH A . 
C 3 HOH 58  658 70  HOH HOH A . 
C 3 HOH 59  659 16  HOH HOH A . 
C 3 HOH 60  660 122 HOH HOH A . 
C 3 HOH 61  661 3   HOH HOH A . 
C 3 HOH 62  662 95  HOH HOH A . 
C 3 HOH 63  663 66  HOH HOH A . 
C 3 HOH 64  664 91  HOH HOH A . 
C 3 HOH 65  665 140 HOH HOH A . 
C 3 HOH 66  666 6   HOH HOH A . 
C 3 HOH 67  667 51  HOH HOH A . 
C 3 HOH 68  668 136 HOH HOH A . 
C 3 HOH 69  669 17  HOH HOH A . 
C 3 HOH 70  670 42  HOH HOH A . 
C 3 HOH 71  671 31  HOH HOH A . 
C 3 HOH 72  672 115 HOH HOH A . 
C 3 HOH 73  673 131 HOH HOH A . 
C 3 HOH 74  674 137 HOH HOH A . 
C 3 HOH 75  675 67  HOH HOH A . 
C 3 HOH 76  676 18  HOH HOH A . 
C 3 HOH 77  677 121 HOH HOH A . 
C 3 HOH 78  678 102 HOH HOH A . 
C 3 HOH 79  679 124 HOH HOH A . 
C 3 HOH 80  680 61  HOH HOH A . 
C 3 HOH 81  681 58  HOH HOH A . 
C 3 HOH 82  682 128 HOH HOH A . 
C 3 HOH 83  683 65  HOH HOH A . 
C 3 HOH 84  684 35  HOH HOH A . 
C 3 HOH 85  685 64  HOH HOH A . 
C 3 HOH 86  686 48  HOH HOH A . 
C 3 HOH 87  687 119 HOH HOH A . 
C 3 HOH 88  688 33  HOH HOH A . 
C 3 HOH 89  689 73  HOH HOH A . 
C 3 HOH 90  690 50  HOH HOH A . 
C 3 HOH 91  691 96  HOH HOH A . 
C 3 HOH 92  692 71  HOH HOH A . 
C 3 HOH 93  693 94  HOH HOH A . 
C 3 HOH 94  694 37  HOH HOH A . 
C 3 HOH 95  695 43  HOH HOH A . 
C 3 HOH 96  696 36  HOH HOH A . 
C 3 HOH 97  697 2   HOH HOH A . 
C 3 HOH 98  698 62  HOH HOH A . 
C 3 HOH 99  699 123 HOH HOH A . 
C 3 HOH 100 700 34  HOH HOH A . 
C 3 HOH 101 701 11  HOH HOH A . 
C 3 HOH 102 702 134 HOH HOH A . 
C 3 HOH 103 703 108 HOH HOH A . 
C 3 HOH 104 704 74  HOH HOH A . 
C 3 HOH 105 705 120 HOH HOH A . 
C 3 HOH 106 706 113 HOH HOH A . 
C 3 HOH 107 707 27  HOH HOH A . 
C 3 HOH 108 708 126 HOH HOH A . 
C 3 HOH 109 709 85  HOH HOH A . 
C 3 HOH 110 710 13  HOH HOH A . 
C 3 HOH 111 711 78  HOH HOH A . 
C 3 HOH 112 712 97  HOH HOH A . 
C 3 HOH 113 713 105 HOH HOH A . 
C 3 HOH 114 714 45  HOH HOH A . 
C 3 HOH 115 715 82  HOH HOH A . 
C 3 HOH 116 716 84  HOH HOH A . 
C 3 HOH 117 717 114 HOH HOH A . 
C 3 HOH 118 718 72  HOH HOH A . 
C 3 HOH 119 719 32  HOH HOH A . 
C 3 HOH 120 720 81  HOH HOH A . 
C 3 HOH 121 721 93  HOH HOH A . 
C 3 HOH 122 722 24  HOH HOH A . 
C 3 HOH 123 723 133 HOH HOH A . 
C 3 HOH 124 724 110 HOH HOH A . 
C 3 HOH 125 725 116 HOH HOH A . 
C 3 HOH 126 726 79  HOH HOH A . 
C 3 HOH 127 727 107 HOH HOH A . 
C 3 HOH 128 728 127 HOH HOH A . 
C 3 HOH 129 729 44  HOH HOH A . 
C 3 HOH 130 730 103 HOH HOH A . 
C 3 HOH 131 731 92  HOH HOH A . 
C 3 HOH 132 732 104 HOH HOH A . 
C 3 HOH 133 733 112 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 116 ? CG  ? A LYS 116 CG  
2  1 Y 1 A LYS 116 ? CD  ? A LYS 116 CD  
3  1 Y 1 A LYS 116 ? CE  ? A LYS 116 CE  
4  1 Y 1 A LYS 116 ? NZ  ? A LYS 116 NZ  
5  1 Y 1 A GLU 285 ? CG  ? A GLU 285 CG  
6  1 Y 1 A GLU 285 ? CD  ? A GLU 285 CD  
7  1 Y 1 A GLU 285 ? OE1 ? A GLU 285 OE1 
8  1 Y 1 A GLU 285 ? OE2 ? A GLU 285 OE2 
9  1 Y 1 A GLN 379 ? CG  ? A GLN 379 CG  
10 1 Y 1 A GLN 379 ? CD  ? A GLN 379 CD  
11 1 Y 1 A GLN 379 ? OE1 ? A GLN 379 OE1 
12 1 Y 1 A GLN 379 ? NE2 ? A GLN 379 NE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM  ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8VNX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     52.220 
_cell.length_a_esd                 ? 
_cell.length_b                     71.210 
_cell.length_b_esd                 ? 
_cell.length_c                     107.740 
_cell.length_c_esd                 ? 
_cell.volume                       400640.477 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8VNX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8VNX 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.9 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          35.34 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 35.38 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M ammonium tartrate pH 7.2, 18 % PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-01-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-2 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          28.04 
_reflns.entry_id                                       8VNX 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.0 
_reflns.d_resolution_low                               37.49 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     27866 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.0 
_reflns_shell.d_res_low                                     2.06 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2572 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.76 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               42.53 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8VNX 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             37.49 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27839 
_refine.ls_number_reflns_R_free                  1406 
_refine.ls_number_reflns_R_work                  26433 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.41 
_refine.ls_percent_reflns_R_free                 5.05 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2141 
_refine.ls_R_factor_R_free                       0.2557 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2119 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 28.7359 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2190 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        37.49 
_refine_hist.number_atoms_solvent             133 
_refine_hist.number_atoms_total               2959 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2796 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0038  ? 2902 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7282  ? 3933 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0441  ? 430  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0074  ? 501  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 16.4459 ? 1093 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.07  . . 155 2566 99.63 . . . . 0.2519 . . . . . . . . . . . 0.3119 
'X-RAY DIFFRACTION' 2.07 2.15  . . 149 2592 99.75 . . . . 0.2424 . . . . . . . . . . . 0.2950 
'X-RAY DIFFRACTION' 2.15 2.25  . . 125 2638 99.75 . . . . 0.2338 . . . . . . . . . . . 0.2994 
'X-RAY DIFFRACTION' 2.25 2.37  . . 124 2603 99.13 . . . . 0.2404 . . . . . . . . . . . 0.2816 
'X-RAY DIFFRACTION' 2.37 2.51  . . 143 2596 98.85 . . . . 0.2344 . . . . . . . . . . . 0.2417 
'X-RAY DIFFRACTION' 2.51 2.71  . . 139 2645 99.93 . . . . 0.2333 . . . . . . . . . . . 0.2953 
'X-RAY DIFFRACTION' 2.71 2.98  . . 134 2654 99.71 . . . . 0.2393 . . . . . . . . . . . 0.3084 
'X-RAY DIFFRACTION' 2.98 3.41  . . 132 2658 98.97 . . . . 0.2230 . . . . . . . . . . . 0.2656 
'X-RAY DIFFRACTION' 3.41 4.30  . . 134 2689 99.19 . . . . 0.1885 . . . . . . . . . . . 0.2381 
'X-RAY DIFFRACTION' 4.30 37.49 . . 171 2792 99.26 . . . . 0.1819 . . . . . . . . . . . 0.2124 
# 
_struct.entry_id                     8VNX 
_struct.title                        
'A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8VNX 
_struct_keywords.text            'C-Jun terminal kinase 3, JNK3, p38 alpha, Kinase, selectivity, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    MK10_HUMAN 
_struct_ref.pdbx_db_accession          P53779 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCA
AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME
LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA
DSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN
SEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8VNX 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 464 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P53779 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  464 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       464 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 98  ? GLN A 100 ? PRO A 98  GLN A 100 5 ? 3  
HELX_P HELX_P2  AA2 ASN A 101 ? MET A 115 ? ASN A 101 MET A 115 1 ? 15 
HELX_P HELX_P3  AA3 LEU A 153 ? GLN A 158 ? LEU A 153 GLN A 158 1 ? 6  
HELX_P HELX_P4  AA4 ASP A 162 ? ALA A 183 ? ASP A 162 ALA A 183 1 ? 22 
HELX_P HELX_P5  AA5 LYS A 191 ? SER A 193 ? LYS A 191 SER A 193 5 ? 3  
HELX_P HELX_P6  AA6 ALA A 231 ? GLY A 237 ? ALA A 231 GLY A 237 1 ? 7  
HELX_P HELX_P7  AA7 ASN A 243 ? HIS A 259 ? ASN A 243 HIS A 259 1 ? 17 
HELX_P HELX_P8  AA8 ASP A 267 ? GLY A 280 ? ASP A 267 GLY A 280 1 ? 14 
HELX_P HELX_P9  AA9 CYS A 283 ? LYS A 288 ? CYS A 283 LYS A 288 1 ? 6  
HELX_P HELX_P10 AB1 GLN A 291 ? ARG A 301 ? GLN A 291 ARG A 301 1 ? 11 
HELX_P HELX_P11 AB2 THR A 308 ? PHE A 313 ? THR A 308 PHE A 313 1 ? 6  
HELX_P HELX_P12 AB3 PRO A 314 ? PHE A 318 ? PRO A 314 PHE A 318 5 ? 5  
HELX_P HELX_P13 AB4 SER A 322 ? LEU A 340 ? SER A 322 LEU A 340 1 ? 19 
HELX_P HELX_P14 AB5 SER A 349 ? HIS A 356 ? SER A 349 HIS A 356 1 ? 8  
HELX_P HELX_P15 AB6 ILE A 359 ? TYR A 363 ? ILE A 359 TYR A 363 5 ? 5  
HELX_P HELX_P16 AB7 ASP A 364 ? GLU A 369 ? ASP A 364 GLU A 369 1 ? 6  
HELX_P HELX_P17 AB8 THR A 386 ? MET A 399 ? THR A 386 MET A 399 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 48  ? VAL A 53  ? PHE A 48  VAL A 53  
AA1 2 SER A 56  ? LEU A 61  ? SER A 56  LEU A 61  
AA2 1 TYR A 64  ? GLY A 71  ? TYR A 64  GLY A 71  
AA2 2 ILE A 77  ? ASP A 83  ? ILE A 77  ASP A 83  
AA2 3 ARG A 88  ? SER A 96  ? ARG A 88  SER A 96  
AA2 4 ASP A 141 ? GLU A 147 ? ASP A 141 GLU A 147 
AA2 5 ASN A 128 ? PHE A 130 ? ASN A 128 PHE A 130 
AA3 1 ALA A 151 ? ASN A 152 ? ALA A 151 ASN A 152 
AA3 2 ILE A 195 ? VAL A 197 ? ILE A 195 VAL A 197 
AA3 3 LEU A 203 ? ILE A 205 ? LEU A 203 ILE A 205 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 51  ? N VAL A 51  O PHE A 58  ? O PHE A 58  
AA2 1 2 N LYS A 68  ? N LYS A 68  O ALA A 80  ? O ALA A 80  
AA2 2 3 N ASP A 83  ? N ASP A 83  O ARG A 88  ? O ARG A 88  
AA2 3 4 N LEU A 95  ? N LEU A 95  O VAL A 142 ? O VAL A 142 
AA2 4 5 O TYR A 143 ? O TYR A 143 N PHE A 130 ? N PHE A 130 
AA3 1 2 N ALA A 151 ? N ALA A 151 O VAL A 197 ? O VAL A 197 
AA3 2 3 N VAL A 196 ? N VAL A 196 O LYS A 204 ? O LYS A 204 
# 
_pdbx_entry_details.entry_id                   8VNX 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   HOH 
_pdbx_validate_close_contact.auth_seq_id_1    634 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    675 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ILE A 70  ? ? -143.31 -15.26  
2  1 ALA A 74  ? ? -26.36  -90.10  
3  1 ARG A 97  ? ? 27.70   78.35   
4  1 GLN A 140 ? ? -135.32 -47.79  
5  1 ARG A 188 ? ? 78.01   -7.94   
6  1 PHE A 218 ? ? 167.75  121.52  
7  1 MET A 220 ? ? -101.43 43.83   
8  1 ALA A 320 ? ? -156.16 52.25   
9  1 ASP A 364 ? ? -175.24 128.66  
10 1 LEU A 380 ? ? 58.76   166.42  
11 1 ARG A 383 ? ? -104.83 -149.20 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A SER 2   ? A SER 2   
3   1 Y 1 A LEU 3   ? A LEU 3   
4   1 Y 1 A HIS 4   ? A HIS 4   
5   1 Y 1 A PHE 5   ? A PHE 5   
6   1 Y 1 A LEU 6   ? A LEU 6   
7   1 Y 1 A TYR 7   ? A TYR 7   
8   1 Y 1 A TYR 8   ? A TYR 8   
9   1 Y 1 A CYS 9   ? A CYS 9   
10  1 Y 1 A SER 10  ? A SER 10  
11  1 Y 1 A GLU 11  ? A GLU 11  
12  1 Y 1 A PRO 12  ? A PRO 12  
13  1 Y 1 A THR 13  ? A THR 13  
14  1 Y 1 A LEU 14  ? A LEU 14  
15  1 Y 1 A ASP 15  ? A ASP 15  
16  1 Y 1 A VAL 16  ? A VAL 16  
17  1 Y 1 A LYS 17  ? A LYS 17  
18  1 Y 1 A ILE 18  ? A ILE 18  
19  1 Y 1 A ALA 19  ? A ALA 19  
20  1 Y 1 A PHE 20  ? A PHE 20  
21  1 Y 1 A CYS 21  ? A CYS 21  
22  1 Y 1 A GLN 22  ? A GLN 22  
23  1 Y 1 A GLY 23  ? A GLY 23  
24  1 Y 1 A PHE 24  ? A PHE 24  
25  1 Y 1 A ASP 25  ? A ASP 25  
26  1 Y 1 A LYS 26  ? A LYS 26  
27  1 Y 1 A GLN 27  ? A GLN 27  
28  1 Y 1 A VAL 28  ? A VAL 28  
29  1 Y 1 A ASP 29  ? A ASP 29  
30  1 Y 1 A VAL 30  ? A VAL 30  
31  1 Y 1 A SER 31  ? A SER 31  
32  1 Y 1 A TYR 32  ? A TYR 32  
33  1 Y 1 A ILE 33  ? A ILE 33  
34  1 Y 1 A ALA 34  ? A ALA 34  
35  1 Y 1 A LYS 35  ? A LYS 35  
36  1 Y 1 A HIS 36  ? A HIS 36  
37  1 Y 1 A TYR 37  ? A TYR 37  
38  1 Y 1 A ASN 38  ? A ASN 38  
39  1 Y 1 A MET 39  ? A MET 39  
40  1 Y 1 A SER 40  ? A SER 40  
41  1 Y 1 A LYS 41  ? A LYS 41  
42  1 Y 1 A SER 42  ? A SER 42  
43  1 Y 1 A LYS 43  ? A LYS 43  
44  1 Y 1 A VAL 44  ? A VAL 44  
45  1 Y 1 A ARG 212 ? A ARG 212 
46  1 Y 1 A THR 213 ? A THR 213 
47  1 Y 1 A ALA 214 ? A ALA 214 
48  1 Y 1 A GLY 215 ? A GLY 215 
49  1 Y 1 A THR 216 ? A THR 216 
50  1 Y 1 A GLN 374 ? A GLN 374 
51  1 Y 1 A ILE 375 ? A ILE 375 
52  1 Y 1 A TYR 376 ? A TYR 376 
53  1 Y 1 A ASP 377 ? A ASP 377 
54  1 Y 1 A LYS 378 ? A LYS 378 
55  1 Y 1 A SER 401 ? A SER 401 
56  1 Y 1 A GLU 402 ? A GLU 402 
57  1 Y 1 A GLU 403 ? A GLU 403 
58  1 Y 1 A LYS 404 ? A LYS 404 
59  1 Y 1 A THR 405 ? A THR 405 
60  1 Y 1 A LYS 406 ? A LYS 406 
61  1 Y 1 A ASN 407 ? A ASN 407 
62  1 Y 1 A GLY 408 ? A GLY 408 
63  1 Y 1 A VAL 409 ? A VAL 409 
64  1 Y 1 A VAL 410 ? A VAL 410 
65  1 Y 1 A LYS 411 ? A LYS 411 
66  1 Y 1 A GLY 412 ? A GLY 412 
67  1 Y 1 A GLN 413 ? A GLN 413 
68  1 Y 1 A PRO 414 ? A PRO 414 
69  1 Y 1 A SER 415 ? A SER 415 
70  1 Y 1 A PRO 416 ? A PRO 416 
71  1 Y 1 A SER 417 ? A SER 417 
72  1 Y 1 A GLY 418 ? A GLY 418 
73  1 Y 1 A ALA 419 ? A ALA 419 
74  1 Y 1 A ALA 420 ? A ALA 420 
75  1 Y 1 A VAL 421 ? A VAL 421 
76  1 Y 1 A ASN 422 ? A ASN 422 
77  1 Y 1 A SER 423 ? A SER 423 
78  1 Y 1 A SER 424 ? A SER 424 
79  1 Y 1 A GLU 425 ? A GLU 425 
80  1 Y 1 A SER 426 ? A SER 426 
81  1 Y 1 A LEU 427 ? A LEU 427 
82  1 Y 1 A PRO 428 ? A PRO 428 
83  1 Y 1 A PRO 429 ? A PRO 429 
84  1 Y 1 A SER 430 ? A SER 430 
85  1 Y 1 A SER 431 ? A SER 431 
86  1 Y 1 A SER 432 ? A SER 432 
87  1 Y 1 A VAL 433 ? A VAL 433 
88  1 Y 1 A ASN 434 ? A ASN 434 
89  1 Y 1 A ASP 435 ? A ASP 435 
90  1 Y 1 A ILE 436 ? A ILE 436 
91  1 Y 1 A SER 437 ? A SER 437 
92  1 Y 1 A SER 438 ? A SER 438 
93  1 Y 1 A MET 439 ? A MET 439 
94  1 Y 1 A SER 440 ? A SER 440 
95  1 Y 1 A THR 441 ? A THR 441 
96  1 Y 1 A ASP 442 ? A ASP 442 
97  1 Y 1 A GLN 443 ? A GLN 443 
98  1 Y 1 A THR 444 ? A THR 444 
99  1 Y 1 A LEU 445 ? A LEU 445 
100 1 Y 1 A ALA 446 ? A ALA 446 
101 1 Y 1 A SER 447 ? A SER 447 
102 1 Y 1 A ASP 448 ? A ASP 448 
103 1 Y 1 A THR 449 ? A THR 449 
104 1 Y 1 A ASP 450 ? A ASP 450 
105 1 Y 1 A SER 451 ? A SER 451 
106 1 Y 1 A SER 452 ? A SER 452 
107 1 Y 1 A LEU 453 ? A LEU 453 
108 1 Y 1 A GLU 454 ? A GLU 454 
109 1 Y 1 A ALA 455 ? A ALA 455 
110 1 Y 1 A SER 456 ? A SER 456 
111 1 Y 1 A ALA 457 ? A ALA 457 
112 1 Y 1 A GLY 458 ? A GLY 458 
113 1 Y 1 A PRO 459 ? A PRO 459 
114 1 Y 1 A LEU 460 ? A LEU 460 
115 1 Y 1 A GLY 461 ? A GLY 461 
116 1 Y 1 A CYS 462 ? A CYS 462 
117 1 Y 1 A CYS 463 ? A CYS 463 
118 1 Y 1 A ARG 464 ? A ARG 464 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
PHE N    N  N N 250 
PHE CA   C  N S 251 
PHE C    C  N N 252 
PHE O    O  N N 253 
PHE CB   C  N N 254 
PHE CG   C  Y N 255 
PHE CD1  C  Y N 256 
PHE CD2  C  Y N 257 
PHE CE1  C  Y N 258 
PHE CE2  C  Y N 259 
PHE CZ   C  Y N 260 
PHE OXT  O  N N 261 
PHE H    H  N N 262 
PHE H2   H  N N 263 
PHE HA   H  N N 264 
PHE HB2  H  N N 265 
PHE HB3  H  N N 266 
PHE HD1  H  N N 267 
PHE HD2  H  N N 268 
PHE HE1  H  N N 269 
PHE HE2  H  N N 270 
PHE HZ   H  N N 271 
PHE HXT  H  N N 272 
PRO N    N  N N 273 
PRO CA   C  N S 274 
PRO C    C  N N 275 
PRO O    O  N N 276 
PRO CB   C  N N 277 
PRO CG   C  N N 278 
PRO CD   C  N N 279 
PRO OXT  O  N N 280 
PRO H    H  N N 281 
PRO HA   H  N N 282 
PRO HB2  H  N N 283 
PRO HB3  H  N N 284 
PRO HG2  H  N N 285 
PRO HG3  H  N N 286 
PRO HD2  H  N N 287 
PRO HD3  H  N N 288 
PRO HXT  H  N N 289 
SER N    N  N N 290 
SER CA   C  N S 291 
SER C    C  N N 292 
SER O    O  N N 293 
SER CB   C  N N 294 
SER OG   O  N N 295 
SER OXT  O  N N 296 
SER H    H  N N 297 
SER H2   H  N N 298 
SER HA   H  N N 299 
SER HB2  H  N N 300 
SER HB3  H  N N 301 
SER HG   H  N N 302 
SER HXT  H  N N 303 
THR N    N  N N 304 
THR CA   C  N S 305 
THR C    C  N N 306 
THR O    O  N N 307 
THR CB   C  N R 308 
THR OG1  O  N N 309 
THR CG2  C  N N 310 
THR OXT  O  N N 311 
THR H    H  N N 312 
THR H2   H  N N 313 
THR HA   H  N N 314 
THR HB   H  N N 315 
THR HG1  H  N N 316 
THR HG21 H  N N 317 
THR HG22 H  N N 318 
THR HG23 H  N N 319 
THR HXT  H  N N 320 
TRP N    N  N N 321 
TRP CA   C  N S 322 
TRP C    C  N N 323 
TRP O    O  N N 324 
TRP CB   C  N N 325 
TRP CG   C  Y N 326 
TRP CD1  C  Y N 327 
TRP CD2  C  Y N 328 
TRP NE1  N  Y N 329 
TRP CE2  C  Y N 330 
TRP CE3  C  Y N 331 
TRP CZ2  C  Y N 332 
TRP CZ3  C  Y N 333 
TRP CH2  C  Y N 334 
TRP OXT  O  N N 335 
TRP H    H  N N 336 
TRP H2   H  N N 337 
TRP HA   H  N N 338 
TRP HB2  H  N N 339 
TRP HB3  H  N N 340 
TRP HD1  H  N N 341 
TRP HE1  H  N N 342 
TRP HE3  H  N N 343 
TRP HZ2  H  N N 344 
TRP HZ3  H  N N 345 
TRP HH2  H  N N 346 
TRP HXT  H  N N 347 
TYR N    N  N N 348 
TYR CA   C  N S 349 
TYR C    C  N N 350 
TYR O    O  N N 351 
TYR CB   C  N N 352 
TYR CG   C  Y N 353 
TYR CD1  C  Y N 354 
TYR CD2  C  Y N 355 
TYR CE1  C  Y N 356 
TYR CE2  C  Y N 357 
TYR CZ   C  Y N 358 
TYR OH   O  N N 359 
TYR OXT  O  N N 360 
TYR H    H  N N 361 
TYR H2   H  N N 362 
TYR HA   H  N N 363 
TYR HB2  H  N N 364 
TYR HB3  H  N N 365 
TYR HD1  H  N N 366 
TYR HD2  H  N N 367 
TYR HE1  H  N N 368 
TYR HE2  H  N N 369 
TYR HH   H  N N 370 
TYR HXT  H  N N 371 
VAL N    N  N N 372 
VAL CA   C  N S 373 
VAL C    C  N N 374 
VAL O    O  N N 375 
VAL CB   C  N N 376 
VAL CG1  C  N N 377 
VAL CG2  C  N N 378 
VAL OXT  O  N N 379 
VAL H    H  N N 380 
VAL H2   H  N N 381 
VAL HA   H  N N 382 
VAL HB   H  N N 383 
VAL HG11 H  N N 384 
VAL HG12 H  N N 385 
VAL HG13 H  N N 386 
VAL HG21 H  N N 387 
VAL HG22 H  N N 388 
VAL HG23 H  N N 389 
VAL HXT  H  N N 390 
WHQ C13  C  Y N 391 
WHQ C15  C  Y N 392 
WHQ C17  C  Y N 393 
WHQ C21  C  N N 394 
WHQ O01  O  N N 395 
WHQ C11  C  Y N 396 
WHQ C12  C  Y N 397 
WHQ C16  C  Y N 398 
WHQ C19  C  N N 399 
WHQ CL1  CL N N 400 
WHQ C1   C  Y N 401 
WHQ C10  C  Y N 402 
WHQ C14  C  Y N 403 
WHQ C18  C  N N 404 
WHQ C2   C  Y N 405 
WHQ C20  C  N N 406 
WHQ C3   C  Y N 407 
WHQ C4   C  Y N 408 
WHQ C5   C  Y N 409 
WHQ C6   C  Y N 410 
WHQ C7   C  Y N 411 
WHQ C8   C  Y N 412 
WHQ C9   C  Y N 413 
WHQ F1   F  N N 414 
WHQ N1   N  Y N 415 
WHQ N2   N  Y N 416 
WHQ N3   N  N N 417 
WHQ N4   N  N N 418 
WHQ O1   O  N N 419 
WHQ S1   S  Y N 420 
WHQ H7   H  N N 421 
WHQ H8   H  N N 422 
WHQ H9   H  N N 423 
WHQ H21  H  N N 424 
WHQ H17  H  N N 425 
WHQ H16  H  N N 426 
WHQ H5   H  N N 427 
WHQ H6   H  N N 428 
WHQ H12  H  N N 429 
WHQ H13  H  N N 430 
WHQ H11  H  N N 431 
WHQ H15  H  N N 432 
WHQ H14  H  N N 433 
WHQ H1   H  N N 434 
WHQ H2   H  N N 435 
WHQ H3   H  N N 436 
WHQ H4   H  N N 437 
WHQ H10  H  N N 438 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
WHQ C19 N4   sing N N 376 
WHQ N4  C18  sing N N 377 
WHQ C18 O01  doub N N 378 
WHQ C18 C16  sing N N 379 
WHQ C15 C16  doub Y N 380 
WHQ C15 C1   sing Y N 381 
WHQ C16 S1   sing Y N 382 
WHQ N2  C4   doub Y N 383 
WHQ N2  N1   sing Y N 384 
WHQ C4  C3   sing Y N 385 
WHQ C1  N1   sing N N 386 
WHQ C1  C17  doub Y N 387 
WHQ N1  C2   sing Y N 388 
WHQ S1  C17  sing Y N 389 
WHQ C3  C2   doub Y N 390 
WHQ C3  C8   sing Y N 391 
WHQ C2  C5   sing Y N 392 
WHQ C8  C7   doub Y N 393 
WHQ C5  C6   doub Y N 394 
WHQ F1  C14  sing N N 395 
WHQ C7  C6   sing Y N 396 
WHQ C7  N3   sing N N 397 
WHQ C13 C14  doub Y N 398 
WHQ C13 C12  sing Y N 399 
WHQ C6  C20  sing N N 400 
WHQ C14 C9   sing Y N 401 
WHQ C12 C11  doub Y N 402 
WHQ C9  N3   sing N N 403 
WHQ C9  C10  doub Y N 404 
WHQ C11 C10  sing Y N 405 
WHQ C10 CL1  sing N N 406 
WHQ C20 O1   sing N N 407 
WHQ O1  C21  sing N N 408 
WHQ C13 H7   sing N N 409 
WHQ C15 H8   sing N N 410 
WHQ C17 H9   sing N N 411 
WHQ C21 H21  sing N N 412 
WHQ C21 H17  sing N N 413 
WHQ C21 H16  sing N N 414 
WHQ C11 H5   sing N N 415 
WHQ C12 H6   sing N N 416 
WHQ C19 H12  sing N N 417 
WHQ C19 H13  sing N N 418 
WHQ C19 H11  sing N N 419 
WHQ C20 H15  sing N N 420 
WHQ C20 H14  sing N N 421 
WHQ C4  H1   sing N N 422 
WHQ C5  H2   sing N N 423 
WHQ C8  H3   sing N N 424 
WHQ N3  H4   sing N N 425 
WHQ N4  H10  sing N N 426 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Institute on Aging (NIH/NIA)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7S1N 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8VNX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019150 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014043 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009282 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . ASP A 1 45  ? 21.60600 8.51700   62.29700 1.000 90.19812  ? 45  ASP A N    1 
ATOM   2    C  CA   . ASP A 1 45  ? 20.69200 9.60300   62.63000 1.000 95.03343  ? 45  ASP A CA   1 
ATOM   3    C  C    . ASP A 1 45  ? 20.37900 10.43500  61.39100 1.000 87.66119  ? 45  ASP A C    1 
ATOM   4    O  O    . ASP A 1 45  ? 19.22600 10.54100  60.97300 1.000 82.96206  ? 45  ASP A O    1 
ATOM   5    C  CB   . ASP A 1 45  ? 21.28800 10.49100  63.72400 1.000 102.75993 ? 45  ASP A CB   1 
ATOM   6    C  CG   . ASP A 1 45  ? 21.54700 9.73600   65.01400 1.000 105.91643 ? 45  ASP A CG   1 
ATOM   7    O  OD1  . ASP A 1 45  ? 20.80200 8.77600   65.30200 1.000 114.90833 ? 45  ASP A OD1  1 
ATOM   8    O  OD2  . ASP A 1 45  ? 22.49500 10.10400  65.73900 1.000 105.65995 ? 45  ASP A OD2  1 
ATOM   9    H  HA   . ASP A 1 45  ? 19.86200 9.23200   62.96900 1.000 113.97988 ? 45  ASP A HA   1 
ATOM   10   H  HB2  . ASP A 1 45  ? 22.13300 10.85300  63.41300 1.000 123.25167 ? 45  ASP A HB2  1 
ATOM   11   H  HB3  . ASP A 1 45  ? 20.67000 11.21300  63.91800 1.000 123.25167 ? 45  ASP A HB3  1 
ATOM   12   N  N    . ASN A 1 46  ? 21.42000 11.02400  60.81000 1.000 64.51102  ? 46  ASN A N    1 
ATOM   13   C  CA   . ASN A 1 46  ? 21.25200 11.84300  59.62100 1.000 55.75745  ? 46  ASN A CA   1 
ATOM   14   C  C    . ASN A 1 46  ? 20.80100 10.98500  58.44300 1.000 51.08653  ? 46  ASN A C    1 
ATOM   15   O  O    . ASN A 1 46  ? 21.18900 9.82300   58.30600 1.000 50.24648  ? 46  ASN A O    1 
ATOM   16   C  CB   . ASN A 1 46  ? 22.55900 12.56100  59.28700 1.000 61.78862  ? 46  ASN A CB   1 
ATOM   17   C  CG   . ASN A 1 46  ? 22.48400 13.34200  57.98800 1.000 60.54882  ? 46  ASN A CG   1 
ATOM   18   O  OD1  . ASN A 1 46  ? 21.49400 14.02100  57.71100 1.000 56.34596  ? 46  ASN A OD1  1 
ATOM   19   N  ND2  . ASN A 1 46  ? 23.53900 13.25400  57.18600 1.000 55.23502  ? 46  ASN A ND2  1 
ATOM   20   H  H    . ASN A 1 46  ? 22.23300 10.96300  61.08500 1.000 77.35298  ? 46  ASN A H    1 
ATOM   21   H  HA   . ASN A 1 46  ? 20.57300 12.51800  59.77800 1.000 66.84870  ? 46  ASN A HA   1 
ATOM   22   H  HB2  . ASN A 1 46  ? 22.76900 13.18400  60.00000 1.000 74.08611  ? 46  ASN A HB2  1 
ATOM   23   H  HB3  . ASN A 1 46  ? 23.26800 11.90400  59.20100 1.000 74.08611  ? 46  ASN A HB3  1 
ATOM   24   H  HD21 . ASN A 1 46  ? 24.21400 12.77400  57.41500 1.000 66.22178  ? 46  ASN A HD21 1 
ATOM   25   H  HD22 . ASN A 1 46  ? 23.54600 13.67800  56.43800 1.000 66.22178  ? 46  ASN A HD22 1 
ATOM   26   N  N    . GLN A 1 47  ? 19.96600 11.57700  57.58700 1.000 39.97502  ? 47  GLN A N    1 
ATOM   27   C  CA   . GLN A 1 47  ? 19.39700 10.85000  56.46100 1.000 53.25212  ? 47  GLN A CA   1 
ATOM   28   C  C    . GLN A 1 47  ? 20.35600 10.70200  55.28500 1.000 35.32972  ? 47  GLN A C    1 
ATOM   29   O  O    . GLN A 1 47  ? 20.11500 9.85700   54.41900 1.000 37.63641  ? 47  GLN A O    1 
ATOM   30   C  CB   . GLN A 1 47  ? 18.12900 11.55000  55.96500 1.000 47.07926  ? 47  GLN A CB   1 
ATOM   31   C  CG   . GLN A 1 47  ? 16.92000 11.42800  56.88100 1.000 51.01137  ? 47  GLN A CG   1 
ATOM   32   C  CD   . GLN A 1 47  ? 15.66500 12.08600  56.30700 1.000 57.50535  ? 47  GLN A CD   1 
ATOM   33   O  OE1  . GLN A 1 47  ? 14.56400 11.88000  56.81700 1.000 47.32014  ? 47  GLN A OE1  1 
ATOM   34   N  NE2  . GLN A 1 47  ? 15.82900 12.88300  55.25200 1.000 59.65605  ? 47  GLN A NE2  1 
ATOM   35   H  H    . GLN A 1 47  ? 19.71500 12.39800  57.64000 1.000 47.90979  ? 47  GLN A H    1 
ATOM   36   H  HA   . GLN A 1 47  ? 19.16400 9.96100   56.77400 1.000 63.84231  ? 47  GLN A HA   1 
ATOM   37   H  HB2  . GLN A 1 47  ? 18.32100 12.49600  55.86400 1.000 56.43487  ? 47  GLN A HB2  1 
ATOM   38   H  HB3  . GLN A 1 47  ? 17.88300 11.16800  55.10800 1.000 56.43487  ? 47  GLN A HB3  1 
ATOM   39   H  HG2  . GLN A 1 47  ? 16.72600 10.48800  57.02200 1.000 61.15341  ? 47  GLN A HG2  1 
ATOM   40   H  HG3  . GLN A 1 47  ? 17.12200 11.85600  57.72700 1.000 61.15341  ? 47  GLN A HG3  1 
ATOM   41   H  HE21 . GLN A 1 47  ? 16.61500 13.00700  54.92400 1.000 71.52702  ? 47  GLN A HE21 1 
ATOM   42   H  HE22 . GLN A 1 47  ? 15.15000 13.27400  54.89800 1.000 71.52702  ? 47  GLN A HE22 1 
ATOM   43   N  N    . PHE A 1 48  ? 21.42100 11.49700  55.22600 1.000 40.03026  ? 48  PHE A N    1 
ATOM   44   C  CA   . PHE A 1 48  ? 22.28300 11.55800  54.05600 1.000 32.56615  ? 48  PHE A CA   1 
ATOM   45   C  C    . PHE A 1 48  ? 23.69400 11.08900  54.39300 1.000 41.77592  ? 48  PHE A C    1 
ATOM   46   O  O    . PHE A 1 48  ? 24.08200 10.97200  55.55800 1.000 40.17169  ? 48  PHE A O    1 
ATOM   47   C  CB   . PHE A 1 48  ? 22.34700 12.98300  53.48700 1.000 32.68233  ? 48  PHE A CB   1 
ATOM   48   C  CG   . PHE A 1 48  ? 21.01200 13.54100  53.09300 1.000 37.73941  ? 48  PHE A CG   1 
ATOM   49   C  CD1  . PHE A 1 48  ? 20.21000 14.17500  54.02700 1.000 34.10317  ? 48  PHE A CD1  1 
ATOM   50   C  CD2  . PHE A 1 48  ? 20.56100 13.43800  51.78700 1.000 34.25154  ? 48  PHE A CD2  1 
ATOM   51   C  CE1  . PHE A 1 48  ? 18.98100 14.69200  53.66700 1.000 34.97768  ? 48  PHE A CE1  1 
ATOM   52   C  CE2  . PHE A 1 48  ? 19.33200 13.95200  51.42100 1.000 29.10006  ? 48  PHE A CE2  1 
ATOM   53   C  CZ   . PHE A 1 48  ? 18.54000 14.58000  52.36400 1.000 34.79270  ? 48  PHE A CZ   1 
ATOM   54   H  H    . PHE A 1 48  ? 21.66600 12.01900  55.86400 1.000 47.97608  ? 48  PHE A H    1 
ATOM   55   H  HA   . PHE A 1 48  ? 21.91800 10.96100  53.38500 1.000 39.01914  ? 48  PHE A HA   1 
ATOM   56   H  HB2  . PHE A 1 48  ? 22.72600 13.57000  54.15900 1.000 39.15856  ? 48  PHE A HB2  1 
ATOM   57   H  HB3  . PHE A 1 48  ? 22.90900 12.97700  52.69600 1.000 39.15856  ? 48  PHE A HB3  1 
ATOM   58   H  HD1  . PHE A 1 48  ? 20.50200 14.25200  54.90600 1.000 40.86357  ? 48  PHE A HD1  1 
ATOM   59   H  HD2  . PHE A 1 48  ? 21.09100 13.01700  51.14900 1.000 41.04161  ? 48  PHE A HD2  1 
ATOM   60   H  HE1  . PHE A 1 48  ? 18.45000 15.11600  54.30200 1.000 41.91298  ? 48  PHE A HE1  1 
ATOM   61   H  HE2  . PHE A 1 48  ? 19.03800 13.87600  50.54200 1.000 34.85984  ? 48  PHE A HE2  1 
ATOM   62   H  HZ   . PHE A 1 48  ? 17.71200 14.92600  52.12100 1.000 41.69100  ? 48  PHE A HZ   1 
ATOM   63   N  N    . TYR A 1 49  ? 24.45900 10.82800  53.33300 1.000 28.31342  ? 49  TYR A N    1 
ATOM   64   C  CA   . TYR A 1 49  ? 25.88000 10.53100  53.43500 1.000 28.27312  ? 49  TYR A CA   1 
ATOM   65   C  C    . TYR A 1 49  ? 26.54500 10.99400  52.14600 1.000 27.91381  ? 49  TYR A C    1 
ATOM   66   O  O    . TYR A 1 49  ? 25.88100 11.21800  51.13200 1.000 30.40695  ? 49  TYR A O    1 
ATOM   67   C  CB   . TYR A 1 49  ? 26.13000 9.04100   53.68900 1.000 37.00003  ? 49  TYR A CB   1 
ATOM   68   C  CG   . TYR A 1 49  ? 25.99400 8.16800   52.46100 1.000 27.59224  ? 49  TYR A CG   1 
ATOM   69   C  CD1  . TYR A 1 49  ? 24.74400 7.83400   51.95900 1.000 25.20380  ? 49  TYR A CD1  1 
ATOM   70   C  CD2  . TYR A 1 49  ? 27.11600 7.66700   51.81400 1.000 27.22555  ? 49  TYR A CD2  1 
ATOM   71   C  CE1  . TYR A 1 49  ? 24.61500 7.02800   50.83800 1.000 28.11875  ? 49  TYR A CE1  1 
ATOM   72   C  CE2  . TYR A 1 49  ? 26.99700 6.86200   50.69500 1.000 39.41857  ? 49  TYR A CE2  1 
ATOM   73   C  CZ   . TYR A 1 49  ? 25.74500 6.54700   50.21200 1.000 27.93118  ? 49  TYR A CZ   1 
ATOM   74   O  OH   . TYR A 1 49  ? 25.62600 5.74600   49.10000 1.000 33.20329  ? 49  TYR A OH   1 
ATOM   75   H  H    . TYR A 1 49  ? 24.16700 10.81700  52.52400 1.000 33.91587  ? 49  TYR A H    1 
ATOM   76   H  HA   . TYR A 1 49  ? 26.27300 11.01700  54.17600 1.000 33.86751  ? 49  TYR A HA   1 
ATOM   77   H  HB2  . TYR A 1 49  ? 27.03300 8.93200   54.02800 1.000 44.33980  ? 49  TYR A HB2  1 
ATOM   78   H  HB3  . TYR A 1 49  ? 25.48900 8.72700   54.34600 1.000 44.33980  ? 49  TYR A HB3  1 
ATOM   79   H  HD1  . TYR A 1 49  ? 23.98100 8.15500   52.38200 1.000 30.18432  ? 49  TYR A HD1  1 
ATOM   80   H  HD2  . TYR A 1 49  ? 27.96200 7.87700   52.13900 1.000 32.61042  ? 49  TYR A HD2  1 
ATOM   81   H  HE1  . TYR A 1 49  ? 23.77100 6.81400   50.51000 1.000 33.68226  ? 49  TYR A HE1  1 
ATOM   82   H  HE2  . TYR A 1 49  ? 27.75800 6.53500   50.27100 1.000 47.24204  ? 49  TYR A HE2  1 
ATOM   83   H  HH   . TYR A 1 49  ? 24.81800 5.55400   48.97000 1.000 39.78371  ? 49  TYR A HH   1 
ATOM   84   N  N    . SER A 1 50  ? 27.86700 11.14600  52.19600 1.000 26.08418  ? 50  SER A N    1 
ATOM   85   C  CA   . SER A 1 50  ? 28.62800 11.74400  51.11000 1.000 40.07297  ? 50  SER A CA   1 
ATOM   86   C  C    . SER A 1 50  ? 29.73100 10.80500  50.64000 1.000 43.89686  ? 50  SER A C    1 
ATOM   87   O  O    . SER A 1 50  ? 30.38900 10.14600  51.45100 1.000 40.50783  ? 50  SER A O    1 
ATOM   88   C  CB   . SER A 1 50  ? 29.24400 13.08300  51.53900 1.000 34.57652  ? 50  SER A CB   1 
ATOM   89   O  OG   . SER A 1 50  ? 28.24500 13.98300  51.98500 1.000 35.77984  ? 50  SER A OG   1 
ATOM   90   H  H    . SER A 1 50  ? 28.35200 10.90400  52.86400 1.000 31.24077  ? 50  SER A H    1 
ATOM   91   H  HA   . SER A 1 50  ? 28.03200 11.89600  50.36000 1.000 48.02733  ? 50  SER A HA   1 
ATOM   92   H  HB2  . SER A 1 50  ? 29.87000 12.92400  52.26200 1.000 41.43159  ? 50  SER A HB2  1 
ATOM   93   H  HB3  . SER A 1 50  ? 29.70500 13.47500  50.78100 1.000 41.43159  ? 50  SER A HB3  1 
ATOM   94   H  HG   . SER A 1 50  ? 28.57500 14.74800  52.09100 1.000 42.87557  ? 50  SER A HG   1 
ATOM   95   N  N    . VAL A 1 51  ? 29.92600 10.75600  49.31900 1.000 41.83835  ? 51  VAL A N    1 
ATOM   96   C  CA   . VAL A 1 51  ? 31.01200 10.00700  48.70200 1.000 45.67638  ? 51  VAL A CA   1 
ATOM   97   C  C    . VAL A 1 51  ? 31.54400 10.81500  47.52600 1.000 46.12812  ? 51  VAL A C    1 
ATOM   98   O  O    . VAL A 1 51  ? 30.85500 11.66900  46.96400 1.000 46.79076  ? 51  VAL A O    1 
ATOM   99   C  CB   . VAL A 1 51  ? 30.57800 8.60100   48.22300 1.000 54.45897  ? 51  VAL A CB   1 
ATOM   100  C  CG1  . VAL A 1 51  ? 30.46200 7.65000   49.40400 1.000 56.94977  ? 51  VAL A CG1  1 
ATOM   101  C  CG2  . VAL A 1 51  ? 29.26600 8.67100   47.44900 1.000 41.52823  ? 51  VAL A CG2  1 
ATOM   102  H  H    . VAL A 1 51  ? 29.42600 11.16200  48.74800 1.000 50.14578  ? 51  VAL A H    1 
ATOM   103  H  HA   . VAL A 1 51  ? 31.72300 9.89100   49.35100 1.000 54.75142  ? 51  VAL A HA   1 
ATOM   104  H  HB   . VAL A 1 51  ? 31.25500 8.25300   47.62200 1.000 65.29053  ? 51  VAL A HB   1 
ATOM   105  H  HG11 . VAL A 1 51  ? 30.16000 6.78500   49.08500 1.000 68.27948  ? 51  VAL A HG11 1 
ATOM   106  H  HG12 . VAL A 1 51  ? 31.33200 7.56100   49.82500 1.000 68.27948  ? 51  VAL A HG12 1 
ATOM   107  H  HG13 . VAL A 1 51  ? 29.82300 8.01000   50.03900 1.000 68.27948  ? 51  VAL A HG13 1 
ATOM   108  H  HG21 . VAL A 1 51  ? 29.02300 7.77800   47.15900 1.000 49.77364  ? 51  VAL A HG21 1 
ATOM   109  H  HG22 . VAL A 1 51  ? 28.57700 9.03100   48.02900 1.000 49.77364  ? 51  VAL A HG22 1 
ATOM   110  H  HG23 . VAL A 1 51  ? 29.38500 9.24900   46.67900 1.000 49.77364  ? 51  VAL A HG23 1 
ATOM   111  N  N    . GLU A 1 52  ? 32.79100 10.53300  47.15900 1.000 51.54157  ? 52  GLU A N    1 
ATOM   112  C  CA   . GLU A 1 52  ? 33.45800 11.21400  46.05600 1.000 53.73273  ? 52  GLU A CA   1 
ATOM   113  C  C    . GLU A 1 52  ? 33.41700 10.31100  44.83000 1.000 66.59650  ? 52  GLU A C    1 
ATOM   114  O  O    . GLU A 1 52  ? 34.07800 9.26700   44.79400 1.000 77.04005  ? 52  GLU A O    1 
ATOM   115  C  CB   . GLU A 1 52  ? 34.89600 11.57100  46.42200 1.000 60.24790  ? 52  GLU A CB   1 
ATOM   116  C  CG   . GLU A 1 52  ? 35.48500 12.67800  45.56200 1.000 78.41681  ? 52  GLU A CG   1 
ATOM   117  C  CD   . GLU A 1 52  ? 34.88000 14.03600  45.86700 1.000 82.11059  ? 52  GLU A CD   1 
ATOM   118  O  OE1  . GLU A 1 52  ? 34.24000 14.17900  46.93100 1.000 74.99370  ? 52  GLU A OE1  1 
ATOM   119  O  OE2  . GLU A 1 52  ? 35.04100 14.95900  45.04000 1.000 80.14608  ? 52  GLU A OE2  1 
ATOM   120  H  H    . GLU A 1 52  ? 33.28000 9.93900   47.54200 1.000 61.78964  ? 52  GLU A H    1 
ATOM   121  H  HA   . GLU A 1 52  ? 32.98100 12.03300  45.85400 1.000 64.41903  ? 52  GLU A HA   1 
ATOM   122  H  HB2  . GLU A 1 52  ? 34.92000 11.86700  47.34500 1.000 72.23724  ? 52  GLU A HB2  1 
ATOM   123  H  HB3  . GLU A 1 52  ? 35.45200 10.78300  46.31200 1.000 72.23724  ? 52  GLU A HB3  1 
ATOM   124  H  HG2  . GLU A 1 52  ? 36.43900 12.73100  45.72400 1.000 94.03993  ? 52  GLU A HG2  1 
ATOM   125  H  HG3  . GLU A 1 52  ? 35.31700 12.47700  44.62800 1.000 94.03993  ? 52  GLU A HG3  1 
ATOM   126  N  N    . VAL A 1 53  ? 32.63600 10.71100  43.83100 1.000 70.32008  ? 53  VAL A N    1 
ATOM   127  C  CA   . VAL A 1 53  ? 32.57700 10.03200  42.54400 1.000 73.77779  ? 53  VAL A CA   1 
ATOM   128  C  C    . VAL A 1 53  ? 33.30800 10.90200  41.53200 1.000 77.08632  ? 53  VAL A C    1 
ATOM   129  O  O    . VAL A 1 53  ? 33.09100 12.12000  41.48100 1.000 69.21065  ? 53  VAL A O    1 
ATOM   130  C  CB   . VAL A 1 53  ? 31.12800 9.77000   42.10200 1.000 70.54898  ? 53  VAL A CB   1 
ATOM   131  C  CG1  . VAL A 1 53  ? 30.38500 11.09200  41.90100 1.000 63.91854  ? 53  VAL A CG1  1 
ATOM   132  C  CG2  . VAL A 1 53  ? 31.12100 8.92100   40.84000 1.000 63.48779  ? 53  VAL A CG2  1 
ATOM   133  H  H    . VAL A 1 53  ? 32.11500 11.39300  43.87900 1.000 84.32386  ? 53  VAL A H    1 
ATOM   134  H  HA   . VAL A 1 53  ? 33.02800 9.17500   42.60600 1.000 88.47311  ? 53  VAL A HA   1 
ATOM   135  H  HB   . VAL A 1 53  ? 30.65600 9.28000   42.79300 1.000 84.59854  ? 53  VAL A HB   1 
ATOM   136  H  HG11 . VAL A 1 53  ? 29.44400 10.90600  41.75400 1.000 76.64201  ? 53  VAL A HG11 1 
ATOM   137  H  HG12 . VAL A 1 53  ? 30.49400 11.63900  42.69400 1.000 76.64201  ? 53  VAL A HG12 1 
ATOM   138  H  HG13 . VAL A 1 53  ? 30.75600 11.54800  41.13000 1.000 76.64201  ? 53  VAL A HG13 1 
ATOM   139  H  HG21 . VAL A 1 53  ? 30.20700 8.66900   40.63400 1.000 76.12511  ? 53  VAL A HG21 1 
ATOM   140  H  HG22 . VAL A 1 53  ? 31.49500 9.43700   40.10900 1.000 76.12511  ? 53  VAL A HG22 1 
ATOM   141  H  HG23 . VAL A 1 53  ? 31.65600 8.12600   40.99100 1.000 76.12511  ? 53  VAL A HG23 1 
ATOM   142  N  N    . GLY A 1 54  ? 34.16300 10.28200  40.72500 1.000 82.93529  ? 54  GLY A N    1 
ATOM   143  C  CA   . GLY A 1 54  ? 35.04800 11.04300  39.86900 1.000 90.48455  ? 54  GLY A CA   1 
ATOM   144  C  C    . GLY A 1 54  ? 35.80700 12.07100  40.68200 1.000 88.74127  ? 54  GLY A C    1 
ATOM   145  O  O    . GLY A 1 54  ? 36.70600 11.72100  41.45100 1.000 88.27946  ? 54  GLY A O    1 
ATOM   146  H  H    . GLY A 1 54  ? 34.24600 9.42800   40.66000 1.000 99.46211  ? 54  GLY A H    1 
ATOM   147  H  HA2  . GLY A 1 54  ? 35.68400 10.44900  39.44000 1.000 108.52122 ? 54  GLY A HA2  1 
ATOM   148  H  HA3  . GLY A 1 54  ? 34.53200 11.50000  39.18600 1.000 108.52122 ? 54  GLY A HA3  1 
ATOM   149  N  N    . ASP A 1 55  ? 35.44100 13.34600  40.53000 1.000 83.90927  ? 55  ASP A N    1 
ATOM   150  C  CA   . ASP A 1 55  ? 35.98900 14.41200  41.35800 1.000 84.43506  ? 55  ASP A CA   1 
ATOM   151  C  C    . ASP A 1 55  ? 34.89400 15.26900  41.98500 1.000 80.24489  ? 55  ASP A C    1 
ATOM   152  O  O    . ASP A 1 55  ? 35.20600 16.27800  42.62700 1.000 78.44903  ? 55  ASP A O    1 
ATOM   153  C  CB   . ASP A 1 55  ? 36.94200 15.29300  40.54300 1.000 100.57753 ? 55  ASP A CB   1 
ATOM   154  C  CG   . ASP A 1 55  ? 38.03800 15.90900  41.39200 1.000 107.66557 ? 55  ASP A CG   1 
ATOM   155  O  OD1  . ASP A 1 55  ? 38.53300 15.22900  42.31600 1.000 113.66535 ? 55  ASP A OD1  1 
ATOM   156  O  OD2  . ASP A 1 55  ? 38.40800 17.07400  41.13400 1.000 100.08230 ? 55  ASP A OD2  1 
ATOM   157  H  H    . ASP A 1 55  ? 34.87100 13.61800  39.94700 1.000 100.63089 ? 55  ASP A H    1 
ATOM   158  H  HA   . ASP A 1 55  ? 36.50400 14.01600  42.07900 1.000 101.26183 ? 55  ASP A HA   1 
ATOM   159  H  HB2  . ASP A 1 55  ? 37.36200 14.75300  39.85500 1.000 120.63279 ? 55  ASP A HB2  1 
ATOM   160  H  HB3  . ASP A 1 55  ? 36.43600 16.01400  40.13500 1.000 120.63279 ? 55  ASP A HB3  1 
ATOM   161  N  N    . SER A 1 56  ? 33.62800 14.89600  41.81600 1.000 74.16573  ? 56  SER A N    1 
ATOM   162  C  CA   . SER A 1 56  ? 32.50500 15.58800  42.42900 1.000 70.17870  ? 56  SER A CA   1 
ATOM   163  C  C    . SER A 1 56  ? 32.09200 14.87500  43.71100 1.000 69.07967  ? 56  SER A C    1 
ATOM   164  O  O    . SER A 1 56  ? 32.28200 13.66400  43.85600 1.000 71.77702  ? 56  SER A O    1 
ATOM   165  C  CB   . SER A 1 56  ? 31.31600 15.65300  41.46800 1.000 62.73819  ? 56  SER A CB   1 
ATOM   166  O  OG   . SER A 1 56  ? 31.69400 16.20400  40.21900 1.000 68.26729  ? 56  SER A OG   1 
ATOM   167  H  H    . SER A 1 56  ? 33.39000 14.22400  41.33500 1.000 88.93864  ? 56  SER A H    1 
ATOM   168  H  HA   . SER A 1 56  ? 32.76500 16.49600  42.65000 1.000 84.15420  ? 56  SER A HA   1 
ATOM   169  H  HB2  . SER A 1 56  ? 30.97800 14.75500  41.32500 1.000 75.22559  ? 56  SER A HB2  1 
ATOM   170  H  HB3  . SER A 1 56  ? 30.62500 16.20900  41.86000 1.000 75.22559  ? 56  SER A HB3  1 
ATOM   171  H  HG   . SER A 1 56  ? 31.06000 16.13800  39.67200 1.000 81.86051  ? 56  SER A HG   1 
ATOM   172  N  N    . THR A 1 57  ? 31.52200 15.63700  44.64300 1.000 50.66346  ? 57  THR A N    1 
ATOM   173  C  CA   . THR A 1 57  ? 31.01000 15.09400  45.89500 1.000 42.29332  ? 57  THR A CA   1 
ATOM   174  C  C    . THR A 1 57  ? 29.50400 14.89100  45.77300 1.000 38.59975  ? 57  THR A C    1 
ATOM   175  O  O    . THR A 1 57  ? 28.77000 15.83400  45.45700 1.000 48.43128  ? 57  THR A O    1 
ATOM   176  C  CB   . THR A 1 57  ? 31.32500 16.01600  47.07200 1.000 47.47554  ? 57  THR A CB   1 
ATOM   177  O  OG1  . THR A 1 57  ? 32.74300 16.10200  47.25600 1.000 54.97837  ? 57  THR A OG1  1 
ATOM   178  C  CG2  . THR A 1 57  ? 30.68300 15.48600  48.34800 1.000 45.95401  ? 57  THR A CG2  1 
ATOM   179  H  H    . THR A 1 57  ? 31.42000 16.48700  44.56900 1.000 60.73592  ? 57  THR A H    1 
ATOM   180  H  HA   . THR A 1 57  ? 31.43000 14.23500  46.06000 1.000 50.69174  ? 57  THR A HA   1 
ATOM   181  H  HB   . THR A 1 57  ? 30.97000 16.90100  46.89300 1.000 56.91041  ? 57  THR A HB   1 
ATOM   182  H  HG1  . THR A 1 57  ? 33.03700 15.37700  47.56300 1.000 65.91380  ? 57  THR A HG1  1 
ATOM   183  H  HG21 . THR A 1 57  ? 31.07800 15.91800  49.12200 1.000 55.08458  ? 57  THR A HG21 1 
ATOM   184  H  HG22 . THR A 1 57  ? 29.73000 15.66700  48.34000 1.000 55.08458  ? 57  THR A HG22 1 
ATOM   185  H  HG23 . THR A 1 57  ? 30.82200 14.52900  48.41600 1.000 55.08458  ? 57  THR A HG23 1 
ATOM   186  N  N    . PHE A 1 58  ? 29.05000 13.66600  46.02900 1.000 38.92877  ? 58  PHE A N    1 
ATOM   187  C  CA   . PHE A 1 58  ? 27.63700 13.31300  46.00000 1.000 33.49645  ? 58  PHE A CA   1 
ATOM   188  C  C    . PHE A 1 58  ? 27.15100 13.10300  47.42800 1.000 34.59123  ? 58  PHE A C    1 
ATOM   189  O  O    . PHE A 1 58  ? 27.63600 12.20400  48.12300 1.000 34.48305  ? 58  PHE A O    1 
ATOM   190  C  CB   . PHE A 1 58  ? 27.40500 12.05000  45.17100 1.000 39.05331  ? 58  PHE A CB   1 
ATOM   191  C  CG   . PHE A 1 58  ? 26.99300 12.32000  43.75600 1.000 39.74535  ? 58  PHE A CG   1 
ATOM   192  C  CD1  . PHE A 1 58  ? 27.85100 12.96300  42.88000 1.000 42.86939  ? 58  PHE A CD1  1 
ATOM   193  C  CD2  . PHE A 1 58  ? 25.74800 11.92500  43.29700 1.000 45.39369  ? 58  PHE A CD2  1 
ATOM   194  C  CE1  . PHE A 1 58  ? 27.47300 13.20800  41.57800 1.000 36.65852  ? 58  PHE A CE1  1 
ATOM   195  C  CE2  . PHE A 1 58  ? 25.36500 12.17200  41.99200 1.000 32.21754  ? 58  PHE A CE2  1 
ATOM   196  C  CZ   . PHE A 1 58  ? 26.22800 12.81300  41.13500 1.000 38.98538  ? 58  PHE A CZ   1 
ATOM   197  H  H    . PHE A 1 58  ? 29.56000 13.00300  46.22700 1.000 46.65428  ? 58  PHE A H    1 
ATOM   198  H  HA   . PHE A 1 58  ? 27.13200 14.04100  45.60500 1.000 40.13550  ? 58  PHE A HA   1 
ATOM   199  H  HB2  . PHE A 1 58  ? 28.22800 11.53800  45.14700 1.000 46.80373  ? 58  PHE A HB2  1 
ATOM   200  H  HB3  . PHE A 1 58  ? 26.70200 11.52800  45.58900 1.000 46.80373  ? 58  PHE A HB3  1 
ATOM   201  H  HD1  . PHE A 1 58  ? 28.69100 13.23300  43.17400 1.000 51.38304  ? 58  PHE A HD1  1 
ATOM   202  H  HD2  . PHE A 1 58  ? 25.16200 11.48800  43.87400 1.000 54.41219  ? 58  PHE A HD2  1 
ATOM   203  H  HE1  . PHE A 1 58  ? 28.05800 13.63900  40.99700 1.000 43.92998  ? 58  PHE A HE1  1 
ATOM   204  H  HE2  . PHE A 1 58  ? 24.52600 11.90500  41.69400 1.000 38.60081  ? 58  PHE A HE2  1 
ATOM   205  H  HZ   . PHE A 1 58  ? 25.97200 12.98100  40.25700 1.000 46.72221  ? 58  PHE A HZ   1 
ATOM   206  N  N    . THR A 1 59  ? 26.19800 13.92900  47.85900 1.000 28.89383  ? 59  THR A N    1 
ATOM   207  C  CA   . THR A 1 59  ? 25.55900 13.80000  49.16900 1.000 34.21619  ? 59  THR A CA   1 
ATOM   208  C  C    . THR A 1 59  ? 24.12000 13.35700  48.92000 1.000 34.40464  ? 59  THR A C    1 
ATOM   209  O  O    . THR A 1 59  ? 23.27600 14.16100  48.51300 1.000 27.23751  ? 59  THR A O    1 
ATOM   210  C  CB   . THR A 1 59  ? 25.62000 15.11200  49.94400 1.000 39.41913  ? 59  THR A CB   1 
ATOM   211  O  OG1  . THR A 1 59  ? 26.98800 15.51100  50.10300 1.000 34.28170  ? 59  THR A OG1  1 
ATOM   212  C  CG2  . THR A 1 59  ? 24.97800 14.95700  51.32200 1.000 29.34057  ? 59  THR A CG2  1 
ATOM   213  H  H    . THR A 1 59  ? 25.89800 14.59000  47.39800 1.000 34.61236  ? 59  THR A H    1 
ATOM   214  H  HA   . THR A 1 59  ? 26.01400 13.12300  49.69400 1.000 40.99919  ? 59  THR A HA   1 
ATOM   215  H  HB   . THR A 1 59  ? 25.13500 15.79700  49.45700 1.000 47.24272  ? 59  THR A HB   1 
ATOM   216  H  HG1  . THR A 1 59  ? 27.02900 16.22700  50.54000 1.000 41.07780  ? 59  THR A HG1  1 
ATOM   217  H  HG21 . THR A 1 59  ? 25.10100 15.76900  51.83900 1.000 35.14845  ? 59  THR A HG21 1 
ATOM   218  H  HG22 . THR A 1 59  ? 24.02800 14.78600  51.22800 1.000 35.14845  ? 59  THR A HG22 1 
ATOM   219  H  HG23 . THR A 1 59  ? 25.38600 14.21700  51.79800 1.000 35.14845  ? 59  THR A HG23 1 
ATOM   220  N  N    . VAL A 1 60  ? 23.84200 12.07400  49.16400 1.000 27.95402  ? 60  VAL A N    1 
ATOM   221  C  CA   . VAL A 1 60  ? 22.57900 11.46600  48.77600 1.000 23.43949  ? 60  VAL A CA   1 
ATOM   222  C  C    . VAL A 1 60  ? 21.95400 10.75800  49.97000 1.000 24.65690  ? 60  VAL A C    1 
ATOM   223  O  O    . VAL A 1 60  ? 22.61600 10.44900  50.96200 1.000 27.13268  ? 60  VAL A O    1 
ATOM   224  C  CB   . VAL A 1 60  ? 22.76000 10.47700  47.60200 1.000 33.61000  ? 60  VAL A CB   1 
ATOM   225  C  CG1  . VAL A 1 60  ? 23.41500 11.17400  46.42100 1.000 35.11957  ? 60  VAL A CG1  1 
ATOM   226  C  CG2  . VAL A 1 60  ? 23.58400 9.27200   48.04000 1.000 29.12007  ? 60  VAL A CG2  1 
ATOM   227  H  H    . VAL A 1 60  ? 24.38100 11.53200  49.55900 1.000 33.48459  ? 60  VAL A H    1 
ATOM   228  H  HA   . VAL A 1 60  ? 21.96600 12.16900  48.50800 1.000 28.06716  ? 60  VAL A HA   1 
ATOM   229  H  HB   . VAL A 1 60  ? 21.88800 10.15900  47.32000 1.000 40.27176  ? 60  VAL A HB   1 
ATOM   230  H  HG11 . VAL A 1 60  ? 23.42700 10.56800  45.66400 1.000 42.08324  ? 60  VAL A HG11 1 
ATOM   231  H  HG12 . VAL A 1 60  ? 22.90500 11.96900  46.20100 1.000 42.08324  ? 60  VAL A HG12 1 
ATOM   232  H  HG13 . VAL A 1 60  ? 24.32200 11.41800  46.66300 1.000 42.08324  ? 60  VAL A HG13 1 
ATOM   233  H  HG21 . VAL A 1 60  ? 23.88000 8.78800   47.25300 1.000 34.88385  ? 60  VAL A HG21 1 
ATOM   234  H  HG22 . VAL A 1 60  ? 24.35200 9.58200   48.54600 1.000 34.88385  ? 60  VAL A HG22 1 
ATOM   235  H  HG23 . VAL A 1 60  ? 23.03300 8.69700   48.59400 1.000 34.88385  ? 60  VAL A HG23 1 
ATOM   236  N  N    . LEU A 1 61  ? 20.65000 10.50600  49.85700 1.000 30.90472  ? 61  LEU A N    1 
ATOM   237  C  CA   . LEU A 1 61  ? 19.93900 9.74500   50.87200 1.000 28.99863  ? 61  LEU A CA   1 
ATOM   238  C  C    . LEU A 1 61  ? 20.55600 8.36000   51.02700 1.000 29.56494  ? 61  LEU A C    1 
ATOM   239  O  O    . LEU A 1 61  ? 21.08300 7.77700   50.07600 1.000 22.38176  ? 61  LEU A O    1 
ATOM   240  C  CB   . LEU A 1 61  ? 18.46100 9.61700   50.50600 1.000 24.36268  ? 61  LEU A CB   1 
ATOM   241  C  CG   . LEU A 1 61  ? 17.65800 10.91800  50.53700 1.000 27.56296  ? 61  LEU A CG   1 
ATOM   242  C  CD1  . LEU A 1 61  ? 16.36800 10.76800  49.75100 1.000 31.48302  ? 61  LEU A CD1  1 
ATOM   243  C  CD2  . LEU A 1 61  ? 17.36900 11.33100  51.96900 1.000 33.52784  ? 61  LEU A CD2  1 
ATOM   244  H  H    . LEU A 1 61  ? 20.15800 10.76600  49.20200 1.000 37.02542  ? 61  LEU A H    1 
ATOM   245  H  HA   . LEU A 1 61  ? 20.00000 10.20700  51.72300 1.000 34.73811  ? 61  LEU A HA   1 
ATOM   246  H  HB2  . LEU A 1 61  ? 18.40000 9.26100   49.60500 1.000 29.17498  ? 61  LEU A HB2  1 
ATOM   247  H  HB3  . LEU A 1 61  ? 18.04400 9.00500   51.13200 1.000 29.17498  ? 61  LEU A HB3  1 
ATOM   248  H  HG   . LEU A 1 61  ? 18.18100 11.62200  50.12200 1.000 33.01531  ? 61  LEU A HG   1 
ATOM   249  H  HD11 . LEU A 1 61  ? 15.87800 11.60500  49.78300 1.000 37.71938  ? 61  LEU A HD11 1 
ATOM   250  H  HD12 . LEU A 1 61  ? 16.58200 10.54500  48.83100 1.000 37.71938  ? 61  LEU A HD12 1 
ATOM   251  H  HD13 . LEU A 1 61  ? 15.83700 10.05900  50.14700 1.000 37.71938  ? 61  LEU A HD13 1 
ATOM   252  H  HD21 . LEU A 1 61  ? 16.79400 12.11200  51.96200 1.000 40.17317  ? 61  LEU A HD21 1 
ATOM   253  H  HD22 . LEU A 1 61  ? 16.92600 10.59900  52.42600 1.000 40.17317  ? 61  LEU A HD22 1 
ATOM   254  H  HD23 . LEU A 1 61  ? 18.20600 11.54000  52.41300 1.000 40.17317  ? 61  LEU A HD23 1 
ATOM   255  N  N    . LYS A 1 62  ? 20.47200 7.82400   52.24800 1.000 22.88405  ? 62  LYS A N    1 
ATOM   256  C  CA   . LYS A 1 62  ? 21.13600 6.56100   52.54400 1.000 24.42011  ? 62  LYS A CA   1 
ATOM   257  C  C    . LYS A 1 62  ? 20.52100 5.38600   51.79700 1.000 22.52926  ? 62  LYS A C    1 
ATOM   258  O  O    . LYS A 1 62  ? 21.16500 4.33700   51.68700 1.000 23.99513  ? 62  LYS A O    1 
ATOM   259  C  CB   . LYS A 1 62  ? 21.11100 6.30500   54.05500 1.000 26.89352  ? 62  LYS A CB   1 
ATOM   260  C  CG   . LYS A 1 62  ? 22.15500 7.11100   54.81300 1.000 34.68095  ? 62  LYS A CG   1 
ATOM   261  C  CD   . LYS A 1 62  ? 21.78200 7.30500   56.27900 1.000 40.66877  ? 62  LYS A CD   1 
ATOM   262  C  CE   . LYS A 1 62  ? 23.02500 7.42800   57.14600 1.000 52.90004  ? 62  LYS A CE   1 
ATOM   263  N  NZ   . LYS A 1 62  ? 22.75300 8.09600   58.45500 1.000 56.61604  ? 62  LYS A NZ   1 
ATOM   264  H  H    . LYS A 1 62  ? 20.04300 8.16900   52.90900 1.000 27.40062  ? 62  LYS A H    1 
ATOM   265  H  HA   . LYS A 1 62  ? 22.06300 6.62400   52.26600 1.000 29.24389  ? 62  LYS A HA   1 
ATOM   266  H  HB2  . LYS A 1 62  ? 20.23800 6.54600   54.40100 1.000 32.21199  ? 62  LYS A HB2  1 
ATOM   267  H  HB3  . LYS A 1 62  ? 21.28400 5.36400   54.21700 1.000 32.21199  ? 62  LYS A HB3  1 
ATOM   268  H  HG2  . LYS A 1 62  ? 23.00500 6.64500   54.77700 1.000 41.55690  ? 62  LYS A HG2  1 
ATOM   269  H  HG3  . LYS A 1 62  ? 22.23900 7.98700   54.40400 1.000 41.55690  ? 62  LYS A HG3  1 
ATOM   270  H  HD2  . LYS A 1 62  ? 21.25900 8.11600   56.37500 1.000 48.74228  ? 62  LYS A HD2  1 
ATOM   271  H  HD3  . LYS A 1 62  ? 21.26900 6.54100   56.58500 1.000 48.74228  ? 62  LYS A HD3  1 
ATOM   272  H  HE2  . LYS A 1 62  ? 23.37300 6.54100   57.32800 1.000 63.41981  ? 62  LYS A HE2  1 
ATOM   273  H  HE3  . LYS A 1 62  ? 23.68900 7.95500   56.67400 1.000 63.41981  ? 62  LYS A HE3  1 
ATOM   274  H  HZ1  . LYS A 1 62  ? 22.57900 8.95900   58.32600 1.000 67.87901  ? 62  LYS A HZ1  1 
ATOM   275  H  HZ2  . LYS A 1 62  ? 22.05200 7.71500   58.85000 1.000 67.87901  ? 62  LYS A HZ2  1 
ATOM   276  H  HZ3  . LYS A 1 62  ? 23.46100 8.02000   58.98800 1.000 67.87901  ? 62  LYS A HZ3  1 
ATOM   277  N  N    . ARG A 1 63  ? 19.30000 5.53200   51.27500 1.000 23.37000  ? 63  ARG A N    1 
ATOM   278  C  CA   . ARG A 1 63  ? 18.70300 4.46300   50.48000 1.000 29.11576  ? 63  ARG A CA   1 
ATOM   279  C  C    . ARG A 1 63  ? 19.50100 4.15800   49.21900 1.000 25.88283  ? 63  ARG A C    1 
ATOM   280  O  O    . ARG A 1 63  ? 19.40200 3.04300   48.69000 1.000 25.28876  ? 63  ARG A O    1 
ATOM   281  C  CB   . ARG A 1 63  ? 17.27200 4.82800   50.08000 1.000 24.00758  ? 63  ARG A CB   1 
ATOM   282  C  CG   . ARG A 1 63  ? 17.18300 6.07800   49.22300 1.000 25.22627  ? 63  ARG A CG   1 
ATOM   283  C  CD   . ARG A 1 63  ? 15.75100 6.56600   49.09000 1.000 23.23836  ? 63  ARG A CD   1 
ATOM   284  N  NE   . ARG A 1 63  ? 14.97300 5.73100   48.18200 1.000 31.56273  ? 63  ARG A NE   1 
ATOM   285  C  CZ   . ARG A 1 63  ? 13.67000 5.86000   47.97500 1.000 27.92167  ? 63  ARG A CZ   1 
ATOM   286  N  NH1  . ARG A 1 63  ? 12.95300 6.76900   48.61600 1.000 26.51666  ? 63  ARG A NH1  1 
ATOM   287  N  NH2  . ARG A 1 63  ? 13.07100 5.06200   47.09900 1.000 29.06362  ? 63  ARG A NH2  1 
ATOM   288  H  H    . ARG A 1 63  ? 18.80700 6.23000   51.36500 1.000 27.98376  ? 63  ARG A H    1 
ATOM   289  H  HA   . ARG A 1 63  ? 18.67500 3.66500   51.03000 1.000 34.87867  ? 63  ARG A HA   1 
ATOM   290  H  HB2  . ARG A 1 63  ? 16.89200 4.09300   49.57400 1.000 28.74886  ? 63  ARG A HB2  1 
ATOM   291  H  HB3  . ARG A 1 63  ? 16.75200 4.98200   50.88400 1.000 28.74886  ? 63  ARG A HB3  1 
ATOM   292  H  HG2  . ARG A 1 63  ? 17.70800 6.78400   49.63000 1.000 30.21129  ? 63  ARG A HG2  1 
ATOM   293  H  HG3  . ARG A 1 63  ? 17.52100 5.88300   48.33500 1.000 30.21129  ? 63  ARG A HG3  1 
ATOM   294  H  HD2  . ARG A 1 63  ? 15.32400 6.54500   49.96100 1.000 27.82579  ? 63  ARG A HD2  1 
ATOM   295  H  HD3  . ARG A 1 63  ? 15.75300 7.47200   48.74300 1.000 27.82579  ? 63  ARG A HD3  1 
ATOM   296  H  HE   . ARG A 1 63  ? 15.38800 5.11400   47.75100 1.000 37.81504  ? 63  ARG A HE   1 
ATOM   297  H  HH11 . ARG A 1 63  ? 13.33200 7.29400   49.18200 1.000 31.75975  ? 63  ARG A HH11 1 
ATOM   298  H  HH12 . ARG A 1 63  ? 12.10900 6.83500   48.46600 1.000 31.75975  ? 63  ARG A HH12 1 
ATOM   299  H  HH21 . ARG A 1 63  ? 13.52900 4.47100   46.67400 1.000 34.81611  ? 63  ARG A HH21 1 
ATOM   300  H  HH22 . ARG A 1 63  ? 12.22600 5.13600   46.95600 1.000 34.81611  ? 63  ARG A HH22 1 
ATOM   301  N  N    . TYR A 1 64  ? 20.27700 5.11400   48.71800 1.000 23.42677  ? 64  TYR A N    1 
ATOM   302  C  CA   . TYR A 1 64  ? 21.03800 4.92500   47.48600 1.000 26.05018  ? 64  TYR A CA   1 
ATOM   303  C  C    . TYR A 1 64  ? 22.44900 4.47600   47.84800 1.000 38.17248  ? 64  TYR A C    1 
ATOM   304  O  O    . TYR A 1 64  ? 23.16000 5.17500   48.58000 1.000 25.20352  ? 64  TYR A O    1 
ATOM   305  C  CB   . TYR A 1 64  ? 21.05100 6.20800   46.65700 1.000 26.39744  ? 64  TYR A CB   1 
ATOM   306  C  CG   . TYR A 1 64  ? 19.66100 6.72300   46.35000 1.000 25.49467  ? 64  TYR A CG   1 
ATOM   307  C  CD1  . TYR A 1 64  ? 18.78000 5.98000   45.57100 1.000 24.46732  ? 64  TYR A CD1  1 
ATOM   308  C  CD2  . TYR A 1 64  ? 19.22100 7.94000   46.85200 1.000 24.00296  ? 64  TYR A CD2  1 
ATOM   309  C  CE1  . TYR A 1 64  ? 17.50400 6.43900   45.29900 1.000 25.89150  ? 64  TYR A CE1  1 
ATOM   310  C  CE2  . TYR A 1 64  ? 17.94800 8.40900   46.58200 1.000 20.75600  ? 64  TYR A CE2  1 
ATOM   311  C  CZ   . TYR A 1 64  ? 17.09400 7.65600   45.80800 1.000 21.27689  ? 64  TYR A CZ   1 
ATOM   312  O  OH   . TYR A 1 64  ? 15.82400 8.12100   45.54300 1.000 27.21325  ? 64  TYR A OH   1 
ATOM   313  H  H    . TYR A 1 64  ? 20.38000 5.88900   49.07600 1.000 28.05189  ? 64  TYR A H    1 
ATOM   314  H  HA   . TYR A 1 64  ? 20.62800 4.23300   46.94400 1.000 31.19998  ? 64  TYR A HA   1 
ATOM   315  H  HB2  . TYR A 1 64  ? 21.52400 6.89800   47.14900 1.000 31.61669  ? 64  TYR A HB2  1 
ATOM   316  H  HB3  . TYR A 1 64  ? 21.50000 6.03500   45.81500 1.000 31.61669  ? 64  TYR A HB3  1 
ATOM   317  H  HD1  . TYR A 1 64  ? 19.05400 5.16100   45.22800 1.000 29.30055  ? 64  TYR A HD1  1 
ATOM   318  H  HD2  . TYR A 1 64  ? 19.79300 8.45000   47.37900 1.000 28.74331  ? 64  TYR A HD2  1 
ATOM   319  H  HE1  . TYR A 1 64  ? 16.92600 5.93200   44.77600 1.000 31.00956  ? 64  TYR A HE1  1 
ATOM   320  H  HE2  . TYR A 1 64  ? 17.67000 9.22900   46.92200 1.000 24.84697  ? 64  TYR A HE2  1 
ATOM   321  H  HH   . TYR A 1 64  ? 15.32900 7.48600   45.30500 1.000 32.59567  ? 64  TYR A HH   1 
ATOM   322  N  N    . GLN A 1 65  ? 22.84300 3.30200   47.34700 1.000 30.06816  ? 65  GLN A N    1 
ATOM   323  C  CA   . GLN A 1 65  ? 24.11600 2.68800   47.68400 1.000 28.67088  ? 65  GLN A CA   1 
ATOM   324  C  C    . GLN A 1 65  ? 24.87900 2.33700   46.41500 1.000 33.04075  ? 65  GLN A C    1 
ATOM   325  O  O    . GLN A 1 65  ? 24.30300 2.18900   45.33300 1.000 25.70054  ? 65  GLN A O    1 
ATOM   326  C  CB   . GLN A 1 65  ? 23.92500 1.41100   48.52500 1.000 33.29729  ? 65  GLN A CB   1 
ATOM   327  C  CG   . GLN A 1 65  ? 23.35200 1.64400   49.92000 1.000 37.96264  ? 65  GLN A CG   1 
ATOM   328  C  CD   . GLN A 1 65  ? 24.30100 2.40200   50.83400 1.000 43.83589  ? 65  GLN A CD   1 
ATOM   329  O  OE1  . GLN A 1 65  ? 25.45100 2.00500   51.02500 1.000 49.76300  ? 65  GLN A OE1  1 
ATOM   330  N  NE2  . GLN A 1 65  ? 23.81600 3.49300   51.41600 1.000 40.75262  ? 65  GLN A NE2  1 
ATOM   331  H  H    . GLN A 1 65  ? 22.37400 2.83600   46.79700 1.000 36.02156  ? 65  GLN A H    1 
ATOM   332  H  HA   . GLN A 1 65  ? 24.64100 3.32500   48.19300 1.000 34.34481  ? 65  GLN A HA   1 
ATOM   333  H  HB2  . GLN A 1 65  ? 23.31600 0.82100   48.05400 1.000 39.89651  ? 65  GLN A HB2  1 
ATOM   334  H  HB3  . GLN A 1 65  ? 24.78800 0.98100   48.63100 1.000 39.89651  ? 65  GLN A HB3  1 
ATOM   335  H  HG2  . GLN A 1 65  ? 22.53500 2.16100   49.84300 1.000 45.49493  ? 65  GLN A HG2  1 
ATOM   336  H  HG3  . GLN A 1 65  ? 23.16400 0.78500   50.33000 1.000 45.49493  ? 65  GLN A HG3  1 
ATOM   337  H  HE21 . GLN A 1 65  ? 23.00500 3.73600   51.26700 1.000 48.84291  ? 65  GLN A HE21 1 
ATOM   338  H  HE22 . GLN A 1 65  ? 24.31300 3.95700   51.94300 1.000 48.84291  ? 65  GLN A HE22 1 
ATOM   339  N  N    . ASN A 1 66  ? 26.19700 2.20300   46.56700 1.000 29.85380  ? 66  ASN A N    1 
ATOM   340  C  CA   . ASN A 1 66  ? 27.06600 1.70100   45.50800 1.000 35.60927  ? 66  ASN A CA   1 
ATOM   341  C  C    . ASN A 1 66  ? 27.06300 2.64600   44.30600 1.000 31.56668  ? 66  ASN A C    1 
ATOM   342  O  O    . ASN A 1 66  ? 26.72900 2.26500   43.18200 1.000 24.79954  ? 66  ASN A O    1 
ATOM   343  C  CB   . ASN A 1 66  ? 26.63800 0.28700   45.09700 1.000 29.50393  ? 66  ASN A CB   1 
ATOM   344  C  CG   . ASN A 1 66  ? 27.67900 -0.41700  44.25100 1.000 39.62968  ? 66  ASN A CG   1 
ATOM   345  O  OD1  . ASN A 1 66  ? 28.87100 -0.34400  44.53700 1.000 39.29563  ? 66  ASN A OD1  1 
ATOM   346  N  ND2  . ASN A 1 66  ? 27.23300 -1.09300  43.19600 1.000 48.61186  ? 66  ASN A ND2  1 
ATOM   347  H  H    . ASN A 1 66  ? 26.61800 2.40100   47.29100 1.000 35.76432  ? 66  ASN A H    1 
ATOM   348  H  HA   . ASN A 1 66  ? 27.97500 1.66300   45.84400 1.000 42.67089  ? 66  ASN A HA   1 
ATOM   349  H  HB2  . ASN A 1 66  ? 26.49200 -0.24400  45.89600 1.000 35.34447  ? 66  ASN A HB2  1 
ATOM   350  H  HB3  . ASN A 1 66  ? 25.81900 0.34200   44.58000 1.000 35.34447  ? 66  ASN A HB3  1 
ATOM   351  H  HD21 . ASN A 1 66  ? 26.39100 -1.11400  43.02300 1.000 58.27400  ? 66  ASN A HD21 1 
ATOM   352  H  HD22 . ASN A 1 66  ? 27.78700 -1.50800  42.68600 1.000 58.27400  ? 66  ASN A HD22 1 
ATOM   353  N  N    . LEU A 1 67  ? 27.46200 3.89400   44.55600 1.000 24.85132  ? 67  LEU A N    1 
ATOM   354  C  CA   . LEU A 1 67  ? 27.44800 4.91400   43.51100 1.000 33.81134  ? 67  LEU A CA   1 
ATOM   355  C  C    . LEU A 1 67  ? 28.64100 4.73800   42.57600 1.000 36.04149  ? 67  LEU A C    1 
ATOM   356  O  O    . LEU A 1 67  ? 29.79100 4.69600   43.02400 1.000 37.16152  ? 67  LEU A O    1 
ATOM   357  C  CB   . LEU A 1 67  ? 27.46700 6.31400   44.13200 1.000 36.30243  ? 67  LEU A CB   1 
ATOM   358  C  CG   . LEU A 1 67  ? 26.09700 6.93400   44.42200 1.000 35.77706  ? 67  LEU A CG   1 
ATOM   359  C  CD1  . LEU A 1 67  ? 25.32300 6.09900   45.42300 1.000 28.93238  ? 67  LEU A CD1  1 
ATOM   360  C  CD2  . LEU A 1 67  ? 26.23700 8.37700   44.90900 1.000 39.95461  ? 67  LEU A CD2  1 
ATOM   361  H  H    . LEU A 1 67  ? 27.74400 4.17200   45.31900 1.000 29.76134  ? 67  LEU A H    1 
ATOM   362  H  HA   . LEU A 1 67  ? 26.63600 4.82000   42.98900 1.000 40.51337  ? 67  LEU A HA   1 
ATOM   363  H  HB2  . LEU A 1 67  ? 27.94600 6.26600   44.97400 1.000 43.50268  ? 67  LEU A HB2  1 
ATOM   364  H  HB3  . LEU A 1 67  ? 27.92900 6.91000   43.52100 1.000 43.50268  ? 67  LEU A HB3  1 
ATOM   365  H  HG   . LEU A 1 67  ? 25.59000 6.95100   43.59600 1.000 42.87223  ? 67  LEU A HG   1 
ATOM   366  H  HD11 . LEU A 1 67  ? 24.46600 6.52200   45.59200 1.000 34.65862  ? 67  LEU A HD11 1 
ATOM   367  H  HD12 . LEU A 1 67  ? 25.18700 5.21100   45.05600 1.000 34.65862  ? 67  LEU A HD12 1 
ATOM   368  H  HD13 . LEU A 1 67  ? 25.83100 6.04100   46.24700 1.000 34.65862  ? 67  LEU A HD13 1 
ATOM   369  H  HD21 . LEU A 1 67  ? 25.35300 8.74000   45.07600 1.000 47.88530  ? 67  LEU A HD21 1 
ATOM   370  H  HD22 . LEU A 1 67  ? 26.75800 8.38500   45.72800 1.000 47.88530  ? 67  LEU A HD22 1 
ATOM   371  H  HD23 . LEU A 1 67  ? 26.68600 8.89900   44.22600 1.000 47.88530  ? 67  LEU A HD23 1 
ATOM   372  N  N    . LYS A 1 68  ? 28.35900 4.62600   41.27300 1.000 32.53651  ? 68  LYS A N    1 
ATOM   373  C  CA   . LYS A 1 68  ? 29.37600 4.56300   40.23200 1.000 43.93103  ? 68  LYS A CA   1 
ATOM   374  C  C    . LYS A 1 68  ? 29.06600 5.58500   39.14300 1.000 34.29421  ? 68  LYS A C    1 
ATOM   375  O  O    . LYS A 1 68  ? 27.89600 5.77100   38.78400 1.000 33.83735  ? 68  LYS A O    1 
ATOM   376  C  CB   . LYS A 1 68  ? 29.45800 3.16500   39.59000 1.000 36.38498  ? 68  LYS A CB   1 
ATOM   377  C  CG   . LYS A 1 68  ? 29.43800 1.97900   40.54800 1.000 45.68875  ? 68  LYS A CG   1 
ATOM   378  C  CD   . LYS A 1 68  ? 30.57800 2.04600   41.56200 1.000 58.52610  ? 68  LYS A CD   1 
ATOM   379  C  CE   . LYS A 1 68  ? 30.06400 1.89700   42.98200 1.000 60.90789  ? 68  LYS A CE   1 
ATOM   380  N  NZ   . LYS A 1 68  ? 30.95900 2.48100   44.02200 1.000 44.73276  ? 68  LYS A NZ   1 
ATOM   381  H  H    . LYS A 1 68  ? 27.55800 4.58400   40.96200 1.000 38.98357  ? 68  LYS A H    1 
ATOM   382  H  HA   . LYS A 1 68  ? 30.23700 4.76600   40.63100 1.000 52.65700  ? 68  LYS A HA   1 
ATOM   383  H  HB2  . LYS A 1 68  ? 28.70100 3.06200   38.99300 1.000 43.60174  ? 68  LYS A HB2  1 
ATOM   384  H  HB3  . LYS A 1 68  ? 30.28600 3.11200   39.08700 1.000 43.60174  ? 68  LYS A HB3  1 
ATOM   385  H  HG2  . LYS A 1 68  ? 28.59900 1.97600   41.03500 1.000 54.76627  ? 68  LYS A HG2  1 
ATOM   386  H  HG3  . LYS A 1 68  ? 29.53100 1.15700   40.04200 1.000 54.76627  ? 68  LYS A HG3  1 
ATOM   387  H  HD2  . LYS A 1 68  ? 31.20600 1.32800   41.38800 1.000 70.17108  ? 68  LYS A HD2  1 
ATOM   388  H  HD3  . LYS A 1 68  ? 31.02500 2.90400   41.48800 1.000 70.17108  ? 68  LYS A HD3  1 
ATOM   389  H  HE2  . LYS A 1 68  ? 29.20500 2.34400   43.05000 1.000 73.02923  ? 68  LYS A HE2  1 
ATOM   390  H  HE3  . LYS A 1 68  ? 29.96300 0.95300   43.17800 1.000 73.02923  ? 68  LYS A HE3  1 
ATOM   391  H  HZ1  . LYS A 1 68  ? 30.60200 2.36500   44.82900 1.000 53.61907  ? 68  LYS A HZ1  1 
ATOM   392  H  HZ2  . LYS A 1 68  ? 31.75400 2.08200   43.99700 1.000 53.61907  ? 68  LYS A HZ2  1 
ATOM   393  H  HZ3  . LYS A 1 68  ? 31.06800 3.35200   43.87600 1.000 53.61907  ? 68  LYS A HZ3  1 
ATOM   394  N  N    . PRO A 1 69  ? 30.07800 6.23900   38.57800 1.000 44.93961  ? 69  PRO A N    1 
ATOM   395  C  CA   . PRO A 1 69  ? 29.80900 7.24700   37.54800 1.000 49.64374  ? 69  PRO A CA   1 
ATOM   396  C  C    . PRO A 1 69  ? 29.38600 6.59200   36.24400 1.000 40.57724  ? 69  PRO A C    1 
ATOM   397  O  O    . PRO A 1 69  ? 29.70900 5.43600   35.96400 1.000 42.30946  ? 69  PRO A O    1 
ATOM   398  C  CB   . PRO A 1 69  ? 31.14500 7.98500   37.39200 1.000 49.60321  ? 69  PRO A CB   1 
ATOM   399  C  CG   . PRO A 1 69  ? 32.16500 7.20000   38.18500 1.000 62.14194  ? 69  PRO A CG   1 
ATOM   400  C  CD   . PRO A 1 69  ? 31.51700 5.94200   38.68300 1.000 57.80738  ? 69  PRO A CD   1 
ATOM   401  H  HA   . PRO A 1 69  ? 29.13100 7.87500   37.84400 1.000 59.51225  ? 69  PRO A HA   1 
ATOM   402  H  HB2  . PRO A 1 69  ? 31.39100 8.01500   36.45400 1.000 59.46361  ? 69  PRO A HB2  1 
ATOM   403  H  HB3  . PRO A 1 69  ? 31.06100 8.88600   37.74100 1.000 59.46361  ? 69  PRO A HB3  1 
ATOM   404  H  HG2  . PRO A 1 69  ? 32.91500 6.98300   37.60900 1.000 74.51009  ? 69  PRO A HG2  1 
ATOM   405  H  HG3  . PRO A 1 69  ? 32.46700 7.73800   38.93300 1.000 74.51009  ? 69  PRO A HG3  1 
ATOM   406  H  HD2  . PRO A 1 69  ? 31.75600 5.18600   38.12400 1.000 69.30862  ? 69  PRO A HD2  1 
ATOM   407  H  HD3  . PRO A 1 69  ? 31.76700 5.76600   39.60400 1.000 69.30862  ? 69  PRO A HD3  1 
ATOM   408  N  N    . ILE A 1 70  ? 28.64300 7.35300   35.43800 1.000 48.09591  ? 70  ILE A N    1 
ATOM   409  C  CA   . ILE A 1 70  ? 28.21300 6.86900   34.13100 1.000 52.33753  ? 70  ILE A CA   1 
ATOM   410  C  C    . ILE A 1 70  ? 28.21600 7.98900   33.09500 1.000 59.94627  ? 70  ILE A C    1 
ATOM   411  O  O    . ILE A 1 70  ? 28.15900 7.72300   31.88900 1.000 66.14861  ? 70  ILE A O    1 
ATOM   412  C  CB   . ILE A 1 70  ? 26.82000 6.21300   34.21300 1.000 43.60288  ? 70  ILE A CB   1 
ATOM   413  C  CG1  . ILE A 1 70  ? 25.78000 7.20300   34.74200 1.000 40.80451  ? 70  ILE A CG1  1 
ATOM   414  C  CG2  . ILE A 1 70  ? 26.86700 4.98100   35.10100 1.000 50.66134  ? 70  ILE A CG2  1 
ATOM   415  C  CD1  . ILE A 1 70  ? 24.37800 6.63500   34.79900 1.000 38.26163  ? 70  ILE A CD1  1 
ATOM   416  H  H    . ILE A 1 70  ? 28.37800 8.14900   35.62800 1.000 57.65485  ? 70  ILE A H    1 
ATOM   417  H  HA   . ILE A 1 70  ? 28.86200 6.21000   33.84000 1.000 62.74480  ? 70  ILE A HA   1 
ATOM   418  H  HB   . ILE A 1 70  ? 26.56200 5.94800   33.31600 1.000 52.26322  ? 70  ILE A HB   1 
ATOM   419  H  HG12 . ILE A 1 70  ? 26.03000 7.46800   35.64100 1.000 48.90518  ? 70  ILE A HG12 1 
ATOM   420  H  HG13 . ILE A 1 70  ? 25.76300 7.97900   34.16000 1.000 48.90518  ? 70  ILE A HG13 1 
ATOM   421  H  HG21 . ILE A 1 70  ? 26.07000 4.45000   34.94800 1.000 60.73337  ? 70  ILE A HG21 1 
ATOM   422  H  HG22 . ILE A 1 70  ? 27.65700 4.46300   34.88100 1.000 60.73337  ? 70  ILE A HG22 1 
ATOM   423  H  HG23 . ILE A 1 70  ? 26.90400 5.26200   36.02900 1.000 60.73337  ? 70  ILE A HG23 1 
ATOM   424  H  HD11 . ILE A 1 70  ? 23.75600 7.35100   35.00400 1.000 45.85372  ? 70  ILE A HD11 1 
ATOM   425  H  HD12 . ILE A 1 70  ? 24.16000 6.24500   33.93800 1.000 45.85372  ? 70  ILE A HD12 1 
ATOM   426  H  HD13 . ILE A 1 70  ? 24.34000 5.95500   35.48900 1.000 45.85372  ? 70  ILE A HD13 1 
ATOM   427  N  N    . GLY A 1 71  ? 28.28400 9.24300   33.54200 1.000 63.58318  ? 71  GLY A N    1 
ATOM   428  C  CA   . GLY A 1 71  ? 28.25800 10.35300  32.60500 1.000 83.54309  ? 71  GLY A CA   1 
ATOM   429  C  C    . GLY A 1 71  ? 28.49800 11.72100  33.21300 1.000 103.87850 ? 71  GLY A C    1 
ATOM   430  O  O    . GLY A 1 71  ? 28.22500 11.94500  34.39700 1.000 85.14370  ? 71  GLY A O    1 
ATOM   431  H  H    . GLY A 1 71  ? 28.34400 9.46800   34.36900 1.000 76.23957  ? 71  GLY A H    1 
ATOM   432  H  HA2  . GLY A 1 71  ? 28.94200 10.20700  31.93300 1.000 100.19148 ? 71  GLY A HA2  1 
ATOM   433  H  HA3  . GLY A 1 71  ? 27.38900 10.37200  32.17300 1.000 100.19148 ? 71  GLY A HA3  1 
ATOM   434  N  N    . SER A 1 72  ? 29.01200 12.64600  32.40100 1.000 123.99071 ? 72  SER A N    1 
ATOM   435  C  CA   . SER A 1 72  ? 29.24000 14.02700  32.80100 1.000 121.70953 ? 72  SER A CA   1 
ATOM   436  C  C    . SER A 1 72  ? 28.82300 14.93500  31.65000 1.000 125.03623 ? 72  SER A C    1 
ATOM   437  O  O    . SER A 1 72  ? 28.50200 14.46700  30.55500 1.000 129.26681 ? 72  SER A O    1 
ATOM   438  C  CB   . SER A 1 72  ? 30.70900 14.26900  33.17400 1.000 122.69013 ? 72  SER A CB   1 
ATOM   439  O  OG   . SER A 1 72  ? 31.05400 13.59200  34.37000 1.000 125.42279 ? 72  SER A OG   1 
ATOM   440  H  H    . SER A 1 72  ? 29.24300 12.48900  31.58700 1.000 148.72862 ? 72  SER A H    1 
ATOM   441  H  HA   . SER A 1 72  ? 28.69600 14.23700  33.57600 1.000 145.99120 ? 72  SER A HA   1 
ATOM   442  H  HB2  . SER A 1 72  ? 31.27300 13.94400  32.45500 1.000 147.16791 ? 72  SER A HB2  1 
ATOM   443  H  HB3  . SER A 1 72  ? 30.84800 15.22100  33.30100 1.000 147.16791 ? 72  SER A HB3  1 
ATOM   444  H  HG   . SER A 1 72  ? 31.86000 13.73400  34.55800 1.000 150.44711 ? 72  SER A HG   1 
ATOM   445  N  N    . GLY A 1 73  ? 28.82300 16.23300  31.89800 1.000 124.74385 ? 73  GLY A N    1 
ATOM   446  C  CA   . GLY A 1 73  ? 28.58200 17.18500  30.82800 1.000 132.97812 ? 73  GLY A CA   1 
ATOM   447  C  C    . GLY A 1 73  ? 27.84100 18.41200  31.33400 1.000 139.66515 ? 73  GLY A C    1 
ATOM   448  O  O    . GLY A 1 73  ? 27.95500 18.78100  32.50200 1.000 130.17291 ? 73  GLY A O    1 
ATOM   449  H  H    . GLY A 1 73  ? 28.95900 16.58600  32.67000 1.000 149.63238 ? 73  GLY A H    1 
ATOM   450  H  HA2  . GLY A 1 73  ? 29.42800 17.46900  30.44800 1.000 159.51351 ? 73  GLY A HA2  1 
ATOM   451  H  HA3  . GLY A 1 73  ? 28.04900 16.76600  30.13400 1.000 159.51351 ? 73  GLY A HA3  1 
ATOM   452  N  N    . ALA A 1 74  ? 27.08100 19.00500  30.40600 1.000 143.97419 ? 74  ALA A N    1 
ATOM   453  C  CA   . ALA A 1 74  ? 26.42700 20.30000  30.56500 1.000 137.76571 ? 74  ALA A CA   1 
ATOM   454  C  C    . ALA A 1 74  ? 26.12400 20.66500  32.01200 1.000 144.83358 ? 74  ALA A C    1 
ATOM   455  O  O    . ALA A 1 74  ? 26.95100 21.29100  32.68300 1.000 148.82478 ? 74  ALA A O    1 
ATOM   456  C  CB   . ALA A 1 74  ? 25.12800 20.32900  29.74700 1.000 128.23897 ? 74  ALA A CB   1 
ATOM   457  H  H    . ALA A 1 74  ? 26.92300 18.65700  29.63500 1.000 172.70879 ? 74  ALA A H    1 
ATOM   458  H  HA   . ALA A 1 74  ? 27.04600 20.97200  30.23900 1.000 165.25861 ? 74  ALA A HA   1 
ATOM   459  H  HB1  . ALA A 1 74  ? 24.55600 19.60100  30.03800 1.000 153.82653 ? 74  ALA A HB1  1 
ATOM   460  H  HB2  . ALA A 1 74  ? 24.68200 21.17800  29.89200 1.000 153.82653 ? 74  ALA A HB2  1 
ATOM   461  H  HB3  . ALA A 1 74  ? 25.34400 20.22500  28.80700 1.000 153.82653 ? 74  ALA A HB3  1 
ATOM   462  N  N    . GLN A 1 75  ? 24.94500 20.28900  32.49800 1.000 143.00295 ? 75  GLN A N    1 
ATOM   463  C  CA   . GLN A 1 75  ? 24.47800 20.74900  33.80200 1.000 133.74121 ? 75  GLN A CA   1 
ATOM   464  C  C    . GLN A 1 75  ? 24.17500 19.55000  34.69200 1.000 108.60447 ? 75  GLN A C    1 
ATOM   465  O  O    . GLN A 1 75  ? 23.02400 19.32800  35.08100 1.000 95.75340  ? 75  GLN A O    1 
ATOM   466  C  CB   . GLN A 1 75  ? 23.25600 21.65900  33.61100 1.000 130.74289 ? 75  GLN A CB   1 
ATOM   467  C  CG   . GLN A 1 75  ? 22.52300 22.10100  34.87500 1.000 113.74070 ? 75  GLN A CG   1 
ATOM   468  C  CD   . GLN A 1 75  ? 21.49100 23.18000  34.58200 1.000 89.59332  ? 75  GLN A CD   1 
ATOM   469  O  OE1  . GLN A 1 75  ? 21.42200 23.70000  33.46700 1.000 89.07898  ? 75  GLN A OE1  1 
ATOM   470  N  NE2  . GLN A 1 75  ? 20.68200 23.51800  35.58000 1.000 69.91819  ? 75  GLN A NE2  1 
ATOM   471  H  H    . GLN A 1 75  ? 24.39500 19.76700  32.09200 1.000 171.54330 ? 75  GLN A H    1 
ATOM   472  H  HA   . GLN A 1 75  ? 25.15800 21.27300  34.25300 1.000 160.42922 ? 75  GLN A HA   1 
ATOM   473  H  HB2  . GLN A 1 75  ? 23.55000 22.46400  33.15800 1.000 156.83123 ? 75  GLN A HB2  1 
ATOM   474  H  HB3  . GLN A 1 75  ? 22.61200 21.18500  33.06200 1.000 156.83123 ? 75  GLN A HB3  1 
ATOM   475  H  HG2  . GLN A 1 75  ? 22.06400 21.33900  35.26100 1.000 136.42860 ? 75  GLN A HG2  1 
ATOM   476  H  HG3  . GLN A 1 75  ? 23.16400 22.45900  35.50800 1.000 136.42860 ? 75  GLN A HG3  1 
ATOM   477  H  HE21 . GLN A 1 75  ? 20.75800 23.13100  36.34400 1.000 83.84159  ? 75  GLN A HE21 1 
ATOM   478  H  HE22 . GLN A 1 75  ? 20.08300 24.12300  35.46200 1.000 83.84159  ? 75  GLN A HE22 1 
ATOM   479  N  N    . GLY A 1 76  ? 25.20000 18.75700  35.00400 1.000 105.58272 ? 76  GLY A N    1 
ATOM   480  C  CA   . GLY A 1 76  ? 25.02800 17.64700  35.91900 1.000 90.41568  ? 76  GLY A CA   1 
ATOM   481  C  C    . GLY A 1 76  ? 25.98900 16.48700  35.75100 1.000 86.09175  ? 76  GLY A C    1 
ATOM   482  O  O    . GLY A 1 76  ? 26.14800 15.94500  34.65200 1.000 87.11619  ? 76  GLY A O    1 
ATOM   483  H  H    . GLY A 1 76  ? 25.99900 18.84600  34.69700 1.000 126.63902 ? 76  GLY A H    1 
ATOM   484  H  HA2  . GLY A 1 76  ? 25.13000 17.97900  36.82500 1.000 108.43857 ? 76  GLY A HA2  1 
ATOM   485  H  HA3  . GLY A 1 76  ? 24.12900 17.29800  35.81100 1.000 108.43857 ? 76  GLY A HA3  1 
ATOM   486  N  N    . ILE A 1 77  ? 26.64500 16.10700  36.84800 1.000 59.19195  ? 77  ILE A N    1 
ATOM   487  C  CA   . ILE A 1 77  ? 27.33300 14.82400  36.94300 1.000 61.93153  ? 77  ILE A CA   1 
ATOM   488  C  C    . ILE A 1 77  ? 26.30800 13.77800  37.36200 1.000 48.67744  ? 77  ILE A C    1 
ATOM   489  O  O    . ILE A 1 77  ? 25.35600 14.07600  38.09100 1.000 43.32784  ? 77  ILE A O    1 
ATOM   490  C  CB   . ILE A 1 77  ? 28.52000 14.90900  37.92700 1.000 68.30847  ? 77  ILE A CB   1 
ATOM   491  C  CG1  . ILE A 1 77  ? 29.11000 13.52500  38.24000 1.000 69.88626  ? 77  ILE A CG1  1 
ATOM   492  C  CG2  . ILE A 1 77  ? 28.10300 15.58600  39.23300 1.000 60.55237  ? 77  ILE A CG2  1 
ATOM   493  C  CD1  . ILE A 1 77  ? 30.01500 12.97700  37.15800 1.000 75.04090  ? 77  ILE A CD1  1 
ATOM   494  H  H    . ILE A 1 77  ? 26.70600 16.58400  37.56200 1.000 70.97010  ? 77  ILE A H    1 
ATOM   495  H  HA   . ILE A 1 77  ? 27.70200 14.57600  36.08100 1.000 74.25760  ? 77  ILE A HA   1 
ATOM   496  H  HB   . ILE A 1 77  ? 29.20200 15.44100  37.48800 1.000 81.90992  ? 77  ILE A HB   1 
ATOM   497  H  HG12 . ILE A 1 77  ? 29.63100 13.58700  39.05500 1.000 83.80328  ? 77  ILE A HG12 1 
ATOM   498  H  HG13 . ILE A 1 77  ? 28.38100 12.89700  38.35900 1.000 83.80328  ? 77  ILE A HG13 1 
ATOM   499  H  HG21 . ILE A 1 77  ? 28.82300 15.50000  39.87700 1.000 72.60260  ? 77  ILE A HG21 1 
ATOM   500  H  HG22 . ILE A 1 77  ? 27.92500 16.52300  39.05900 1.000 72.60260  ? 77  ILE A HG22 1 
ATOM   501  H  HG23 . ILE A 1 77  ? 27.30300 15.15400  39.57100 1.000 72.60260  ? 77  ILE A HG23 1 
ATOM   502  H  HD11 . ILE A 1 77  ? 30.33000 12.10000  37.42500 1.000 89.98884  ? 77  ILE A HD11 1 
ATOM   503  H  HD12 . ILE A 1 77  ? 29.51400 12.91200  36.33000 1.000 89.98884  ? 77  ILE A HD12 1 
ATOM   504  H  HD13 . ILE A 1 77  ? 30.76800 13.57800  37.04300 1.000 89.98884  ? 77  ILE A HD13 1 
ATOM   505  N  N    . VAL A 1 78  ? 26.48600 12.54100  36.89300 1.000 46.94579  ? 78  VAL A N    1 
ATOM   506  C  CA   . VAL A 1 78  ? 25.47900 11.49800  37.05100 1.000 30.81817  ? 78  VAL A CA   1 
ATOM   507  C  C    . VAL A 1 78  ? 26.12800 10.22600  37.58000 1.000 37.06439  ? 78  VAL A C    1 
ATOM   508  O  O    . VAL A 1 78  ? 27.26000 9.89500   37.21300 1.000 38.66013  ? 78  VAL A O    1 
ATOM   509  C  CB   . VAL A 1 78  ? 24.75000 11.22300  35.71700 1.000 35.10092  ? 78  VAL A CB   1 
ATOM   510  C  CG1  . VAL A 1 78  ? 23.68800 10.15100  35.89500 1.000 38.85999  ? 78  VAL A CG1  1 
ATOM   511  C  CG2  . VAL A 1 78  ? 24.12900 12.50200  35.19000 1.000 33.87767  ? 78  VAL A CG2  1 
ATOM   512  H  H    . VAL A 1 78  ? 27.19200 12.28200  36.47600 1.000 56.27471  ? 78  VAL A H    1 
ATOM   513  H  HA   . VAL A 1 78  ? 24.83100 11.78700  37.71400 1.000 36.92157  ? 78  VAL A HA   1 
ATOM   514  H  HB   . VAL A 1 78  ? 25.39500 10.90100  35.06800 1.000 42.06086  ? 78  VAL A HB   1 
ATOM   515  H  HG11 . VAL A 1 78  ? 23.24000 10.00700  35.04600 1.000 46.57174  ? 78  VAL A HG11 1 
ATOM   516  H  HG12 . VAL A 1 78  ? 24.11300 9.33000   36.18800 1.000 46.57174  ? 78  VAL A HG12 1 
ATOM   517  H  HG13 . VAL A 1 78  ? 23.04700 10.44800  36.56000 1.000 46.57174  ? 78  VAL A HG13 1 
ATOM   518  H  HG21 . VAL A 1 78  ? 23.67100 12.31100  34.35700 1.000 40.59297  ? 78  VAL A HG21 1 
ATOM   519  H  HG22 . VAL A 1 78  ? 23.49700 12.84000  35.84500 1.000 40.59297  ? 78  VAL A HG22 1 
ATOM   520  H  HG23 . VAL A 1 78  ? 24.83000 13.15600  35.04000 1.000 40.59297  ? 78  VAL A HG23 1 
ATOM   521  N  N    . CYS A 1 79  ? 25.39400 9.50800   38.43700 1.000 25.11955  ? 79  CYS A N    1 
ATOM   522  C  CA   . CYS A 1 79  ? 25.83800 8.24500   39.00100 1.000 28.07035  ? 79  CYS A CA   1 
ATOM   523  C  C    . CYS A 1 79  ? 24.75000 7.19200   38.86800 1.000 25.42495  ? 79  CYS A C    1 
ATOM   524  O  O    . CYS A 1 79  ? 23.55600 7.49900   38.91600 1.000 29.47432  ? 79  CYS A O    1 
ATOM   525  C  CB   . CYS A 1 79  ? 26.18900 8.37900   40.48600 1.000 40.47609  ? 79  CYS A CB   1 
ATOM   526  S  SG   . CYS A 1 79  ? 27.70400 9.25900   40.77500 1.000 47.00321  ? 79  CYS A SG   1 
ATOM   527  H  H    . CYS A 1 79  ? 24.61400 9.74500   38.71000 1.000 30.08322  ? 79  CYS A H    1 
ATOM   528  H  HA   . CYS A 1 79  ? 26.62100 7.95200   38.50900 1.000 33.62418  ? 79  CYS A HA   1 
ATOM   529  H  HB2  . CYS A 1 79  ? 25.47500 8.86000   40.93400 1.000 48.51107  ? 79  CYS A HB2  1 
ATOM   530  H  HB3  . CYS A 1 79  ? 26.28200 7.49200   40.86700 1.000 48.51107  ? 79  CYS A HB3  1 
ATOM   531  H  HG   . CYS A 1 79  ? 27.63900 10.33400  40.24500 1.000 56.34361  ? 79  CYS A HG   1 
ATOM   532  N  N    . ALA A 1 80  ? 25.17800 5.94400   38.70500 1.000 27.41329  ? 80  ALA A N    1 
ATOM   533  C  CA   . ALA A 1 80  ? 24.30200 4.80100   38.90000 1.000 26.16286  ? 80  ALA A CA   1 
ATOM   534  C  C    . ALA A 1 80  ? 24.33600 4.40400   40.37100 1.000 26.11301  ? 80  ALA A C    1 
ATOM   535  O  O    . ALA A 1 80  ? 25.33200 4.62500   41.06500 1.000 27.35618  ? 80  ALA A O    1 
ATOM   536  C  CB   . ALA A 1 80  ? 24.72800 3.62400   38.02400 1.000 27.27351  ? 80  ALA A CB   1 
ATOM   537  H  H    . ALA A 1 80  ? 25.98100 5.73400   38.47900 1.000 32.83571  ? 80  ALA A H    1 
ATOM   538  H  HA   . ALA A 1 80  ? 23.39200 5.02600   38.64900 1.000 31.33519  ? 80  ALA A HA   1 
ATOM   539  H  HB1  . ALA A 1 80  ? 24.10800 2.89000   38.15900 1.000 32.66797  ? 80  ALA A HB1  1 
ATOM   540  H  HB2  . ALA A 1 80  ? 24.71500 3.90100   37.09500 1.000 32.66797  ? 80  ALA A HB2  1 
ATOM   541  H  HB3  . ALA A 1 80  ? 25.62400 3.35100   38.27600 1.000 32.66797  ? 80  ALA A HB3  1 
ATOM   542  N  N    . ALA A 1 81  ? 23.23600 3.82900   40.84700 1.000 23.78332  ? 81  ALA A N    1 
ATOM   543  C  CA   . ALA A 1 81  ? 23.16000 3.42400   42.24400 1.000 29.08985  ? 81  ALA A CA   1 
ATOM   544  C  C    . ALA A 1 81  ? 22.05200 2.39700   42.41500 1.000 25.57956  ? 81  ALA A C    1 
ATOM   545  O  O    . ALA A 1 81  ? 21.16500 2.26200   41.56900 1.000 27.78584  ? 81  ALA A O    1 
ATOM   546  C  CB   . ALA A 1 81  ? 22.91600 4.62600   43.16200 1.000 23.75590  ? 81  ALA A CB   1 
ATOM   547  H  H    . ALA A 1 81  ? 22.52800 3.66500   40.38600 1.000 28.47974  ? 81  ALA A H    1 
ATOM   548  H  HA   . ALA A 1 81  ? 23.99800 3.00500   42.49300 1.000 34.84758  ? 81  ALA A HA   1 
ATOM   549  H  HB1  . ALA A 1 81  ? 22.87100 4.31800   44.08100 1.000 28.44684  ? 81  ALA A HB1  1 
ATOM   550  H  HB2  . ALA A 1 81  ? 23.64800 5.25500   43.06100 1.000 28.44684  ? 81  ALA A HB2  1 
ATOM   551  H  HB3  . ALA A 1 81  ? 22.08000 5.04900   42.91400 1.000 28.44684  ? 81  ALA A HB3  1 
ATOM   552  N  N    . TYR A 1 82  ? 22.12600 1.66900   43.52600 1.000 26.14656  ? 82  TYR A N    1 
ATOM   553  C  CA   . TYR A 1 82  ? 21.07300 0.75600   43.94600 1.000 26.89459  ? 82  TYR A CA   1 
ATOM   554  C  C    . TYR A 1 82  ? 20.18600 1.46000   44.96600 1.000 21.67985  ? 82  TYR A C    1 
ATOM   555  O  O    . TYR A 1 82  ? 20.68600 2.04100   45.93500 1.000 26.78869  ? 82  TYR A O    1 
ATOM   556  C  CB   . TYR A 1 82  ? 21.66400 -0.52400  44.54300 1.000 23.99513  ? 82  TYR A CB   1 
ATOM   557  C  CG   . TYR A 1 82  ? 20.64400 -1.44400  45.17900 1.000 22.83605  ? 82  TYR A CG   1 
ATOM   558  C  CD1  . TYR A 1 82  ? 19.66300 -2.06800  44.41700 1.000 25.85574  ? 82  TYR A CD1  1 
ATOM   559  C  CD2  . TYR A 1 82  ? 20.67000 -1.69800  46.54600 1.000 28.44291  ? 82  TYR A CD2  1 
ATOM   560  C  CE1  . TYR A 1 82  ? 18.73000 -2.91500  45.00400 1.000 27.52525  ? 82  TYR A CE1  1 
ATOM   561  C  CE2  . TYR A 1 82  ? 19.74700 -2.54300  47.13700 1.000 32.09031  ? 82  TYR A CE2  1 
ATOM   562  C  CZ   . TYR A 1 82  ? 18.78000 -3.14500  46.36700 1.000 28.08399  ? 82  TYR A CZ   1 
ATOM   563  O  OH   . TYR A 1 82  ? 17.86500 -3.98300  46.96400 1.000 34.22743  ? 82  TYR A OH   1 
ATOM   564  H  H    . TYR A 1 82  ? 22.79500 1.69000   44.06600 1.000 31.31563  ? 82  TYR A H    1 
ATOM   565  H  HA   . TYR A 1 82  ? 20.52900 0.50500   43.18300 1.000 32.21327  ? 82  TYR A HA   1 
ATOM   566  H  HB2  . TYR A 1 82  ? 22.10600 -1.02000  43.83600 1.000 28.73391  ? 82  TYR A HB2  1 
ATOM   567  H  HB3  . TYR A 1 82  ? 22.30600 -0.27900  45.22800 1.000 28.73391  ? 82  TYR A HB3  1 
ATOM   568  H  HD1  . TYR A 1 82  ? 19.62900 -1.91500  43.50000 1.000 30.96665  ? 82  TYR A HD1  1 
ATOM   569  H  HD2  . TYR A 1 82  ? 21.32100 -1.29400  47.07200 1.000 34.07126  ? 82  TYR A HD2  1 
ATOM   570  H  HE1  . TYR A 1 82  ? 18.07700 -3.32500  44.48400 1.000 32.97006  ? 82  TYR A HE1  1 
ATOM   571  H  HE2  . TYR A 1 82  ? 19.78000 -2.70200  48.05300 1.000 38.44813  ? 82  TYR A HE2  1 
ATOM   572  H  HH   . TYR A 1 82  ? 17.37800 -4.34100  46.38000 1.000 41.01268  ? 82  TYR A HH   1 
ATOM   573  N  N    . ASP A 1 83  ? 18.87800 1.41800   44.73500 1.000 25.53358  ? 83  ASP A N    1 
ATOM   574  C  CA   . ASP A 1 83  ? 17.88800 2.00700   45.63400 1.000 21.18081  ? 83  ASP A CA   1 
ATOM   575  C  C    . ASP A 1 83  ? 17.38000 0.88600   46.53300 1.000 24.00354  ? 83  ASP A C    1 
ATOM   576  O  O    . ASP A 1 83  ? 16.55700 0.06700   46.11700 1.000 28.29680  ? 83  ASP A O    1 
ATOM   577  C  CB   . ASP A 1 83  ? 16.76200 2.65900   44.84000 1.000 26.37926  ? 83  ASP A CB   1 
ATOM   578  C  CG   . ASP A 1 83  ? 15.71800 3.31800   45.72400 1.000 27.39752  ? 83  ASP A CG   1 
ATOM   579  O  OD1  . ASP A 1 83  ? 15.73000 3.09300   46.95500 1.000 30.40145  ? 83  ASP A OD1  1 
ATOM   580  O  OD2  . ASP A 1 83  ? 14.88000 4.07200   45.18000 1.000 25.27503  ? 83  ASP A OD2  1 
ATOM   581  H  H    . ASP A 1 83  ? 18.52900 1.04500   44.04400 1.000 30.58006  ? 83  ASP A H    1 
ATOM   582  H  HA   . ASP A 1 83  ? 18.29800 2.69100   46.18600 1.000 25.35674  ? 83  ASP A HA   1 
ATOM   583  H  HB2  . ASP A 1 83  ? 17.13800 3.34100   44.26200 1.000 31.59487  ? 83  ASP A HB2  1 
ATOM   584  H  HB3  . ASP A 1 83  ? 16.31700 1.98100   44.30700 1.000 31.59487  ? 83  ASP A HB3  1 
ATOM   585  N  N    . ALA A 1 84  ? 17.88100 0.85000   47.77000 1.000 25.31012  ? 84  ALA A N    1 
ATOM   586  C  CA   . ALA A 1 84  ? 17.52200 -0.22200  48.69000 1.000 26.80909  ? 84  ALA A CA   1 
ATOM   587  C  C    . ALA A 1 84  ? 16.05400 -0.18300  49.09000 1.000 29.41780  ? 84  ALA A C    1 
ATOM   588  O  O    . ALA A 1 84  ? 15.53800 -1.18200  49.59600 1.000 31.64770  ? 84  ALA A O    1 
ATOM   589  C  CB   . ALA A 1 84  ? 18.39600 -0.15400  49.94400 1.000 32.19619  ? 84  ALA A CB   1 
ATOM   590  H  H    . ALA A 1 84  ? 18.42500 1.43100   48.09600 1.000 30.31190  ? 84  ALA A H    1 
ATOM   591  H  HA   . ALA A 1 84  ? 17.68800 -1.07100  48.25000 1.000 32.11067  ? 84  ALA A HA   1 
ATOM   592  H  HB1  . ALA A 1 84  ? 18.13400 -0.86300  50.55100 1.000 38.57519  ? 84  ALA A HB1  1 
ATOM   593  H  HB2  . ALA A 1 84  ? 19.32500 -0.26500  49.68700 1.000 38.57519  ? 84  ALA A HB2  1 
ATOM   594  H  HB3  . ALA A 1 84  ? 18.27200 0.70900   50.36900 1.000 38.57519  ? 84  ALA A HB3  1 
ATOM   595  N  N    . VAL A 1 85  ? 15.37000 0.93900   48.88200 1.000 20.40508  ? 85  VAL A N    1 
ATOM   596  C  CA   . VAL A 1 85  ? 13.96100 1.02600   49.25000 1.000 22.93465  ? 85  VAL A CA   1 
ATOM   597  C  C    . VAL A 1 85  ? 13.06700 0.49700   48.13900 1.000 27.13853  ? 85  VAL A C    1 
ATOM   598  O  O    . VAL A 1 85  ? 12.07900 -0.19100  48.40400 1.000 29.98631  ? 85  VAL A O    1 
ATOM   599  C  CB   . VAL A 1 85  ? 13.60200 2.47900   49.62000 1.000 29.12900  ? 85  VAL A CB   1 
ATOM   600  C  CG1  . VAL A 1 85  ? 12.09100 2.64600   49.70600 1.000 35.79261  ? 85  VAL A CG1  1 
ATOM   601  C  CG2  . VAL A 1 85  ? 14.26300 2.86400   50.93700 1.000 33.25853  ? 85  VAL A CG2  1 
ATOM   602  H  H    . VAL A 1 85  ? 15.69600 1.65500   48.53300 1.000 24.42586  ? 85  VAL A H    1 
ATOM   603  H  HA   . VAL A 1 85  ? 13.81300 0.47600   50.03500 1.000 27.46134  ? 85  VAL A HA   1 
ATOM   604  H  HB   . VAL A 1 85  ? 13.93000 3.07500   48.92900 1.000 34.89457  ? 85  VAL A HB   1 
ATOM   605  H  HG11 . VAL A 1 85  ? 11.89100 3.47500   50.16800 1.000 42.89089  ? 85  VAL A HG11 1 
ATOM   606  H  HG12 . VAL A 1 85  ? 11.72500 2.67000   48.80900 1.000 42.89089  ? 85  VAL A HG12 1 
ATOM   607  H  HG13 . VAL A 1 85  ? 11.71800 1.89600   50.19600 1.000 42.89089  ? 85  VAL A HG13 1 
ATOM   608  H  HG21 . VAL A 1 85  ? 14.03500 3.78300   51.14800 1.000 39.85000  ? 85  VAL A HG21 1 
ATOM   609  H  HG22 . VAL A 1 85  ? 13.94000 2.27400   51.63700 1.000 39.85000  ? 85  VAL A HG22 1 
ATOM   610  H  HG23 . VAL A 1 85  ? 15.22400 2.77300   50.84600 1.000 39.85000  ? 85  VAL A HG23 1 
ATOM   611  N  N    . LEU A 1 86  ? 13.39900 0.80400   46.88500 1.000 28.39097  ? 86  LEU A N    1 
ATOM   612  C  CA   . LEU A 1 86  ? 12.65900 0.29000   45.74400 1.000 25.55494  ? 86  LEU A CA   1 
ATOM   613  C  C    . LEU A 1 86  ? 13.24500 -1.00600  45.19800 1.000 29.75292  ? 86  LEU A C    1 
ATOM   614  O  O    . LEU A 1 86  ? 12.62000 -1.63500  44.33800 1.000 34.06997  ? 86  LEU A O    1 
ATOM   615  C  CB   . LEU A 1 86  ? 12.61700 1.34000   44.63000 1.000 35.66513  ? 86  LEU A CB   1 
ATOM   616  C  CG   . LEU A 1 86  ? 11.94000 2.66400   44.99700 1.000 36.20157  ? 86  LEU A CG   1 
ATOM   617  C  CD1  . LEU A 1 86  ? 12.16300 3.70900   43.90300 1.000 36.37359  ? 86  LEU A CD1  1 
ATOM   618  C  CD2  . LEU A 1 86  ? 10.45400 2.46600   45.25500 1.000 33.05449  ? 86  LEU A CD2  1 
ATOM   619  H  H    . LEU A 1 86  ? 14.05700 1.31400   46.67200 1.000 34.00893  ? 86  LEU A H    1 
ATOM   620  H  HA   . LEU A 1 86  ? 11.74500 0.11100   46.01700 1.000 30.60569  ? 86  LEU A HA   1 
ATOM   621  H  HB2  . LEU A 1 86  ? 13.52900 1.54400   44.37000 1.000 42.73792  ? 86  LEU A HB2  1 
ATOM   622  H  HB3  . LEU A 1 86  ? 12.13300 0.96700   43.87700 1.000 42.73792  ? 86  LEU A HB3  1 
ATOM   623  H  HG   . LEU A 1 86  ? 12.34000 2.99600   45.81600 1.000 43.38164  ? 86  LEU A HG   1 
ATOM   624  H  HD11 . LEU A 1 86  ? 12.05100 4.59400   44.28400 1.000 43.58807  ? 86  LEU A HD11 1 
ATOM   625  H  HD12 . LEU A 1 86  ? 13.06300 3.61200   43.55200 1.000 43.58807  ? 86  LEU A HD12 1 
ATOM   626  H  HD13 . LEU A 1 86  ? 11.51500 3.56800   43.19500 1.000 43.58807  ? 86  LEU A HD13 1 
ATOM   627  H  HD21 . LEU A 1 86  ? 10.06000 3.31800   45.50200 1.000 39.60515  ? 86  LEU A HD21 1 
ATOM   628  H  HD22 . LEU A 1 86  ? 10.03500 2.13000   44.44700 1.000 39.60515  ? 86  LEU A HD22 1 
ATOM   629  H  HD23 . LEU A 1 86  ? 10.34000 1.82800   45.97600 1.000 39.60515  ? 86  LEU A HD23 1 
ATOM   630  N  N    . ASP A 1 87  ? 14.42400 -1.41200  45.67000 1.000 27.46582  ? 87  ASP A N    1 
ATOM   631  C  CA   . ASP A 1 87  ? 15.07400 -2.64000  45.21300 1.000 25.84546  ? 87  ASP A CA   1 
ATOM   632  C  C    . ASP A 1 87  ? 15.25300 -2.62800  43.69500 1.000 35.29027  ? 87  ASP A C    1 
ATOM   633  O  O    . ASP A 1 87  ? 14.83900 -3.54900  42.98900 1.000 32.46417  ? 87  ASP A O    1 
ATOM   634  C  CB   . ASP A 1 87  ? 14.28500 -3.87100  45.66600 1.000 28.54069  ? 87  ASP A CB   1 
ATOM   635  C  CG   . ASP A 1 87  ? 15.00900 -5.17200  45.37000 1.000 38.14971  ? 87  ASP A CG   1 
ATOM   636  O  OD1  . ASP A 1 87  ? 16.26000 -5.17300  45.34600 1.000 31.95824  ? 87  ASP A OD1  1 
ATOM   637  O  OD2  . ASP A 1 87  ? 14.32400 -6.19200  45.15200 1.000 38.07856  ? 87  ASP A OD2  1 
ATOM   638  H  H    . ASP A 1 87  ? 14.87500 -0.98600  46.26600 1.000 32.89874  ? 87  ASP A H    1 
ATOM   639  H  HA   . ASP A 1 87  ? 15.95900 -2.69000  45.60900 1.000 30.95432  ? 87  ASP A HA   1 
ATOM   640  H  HB2  . ASP A 1 87  ? 14.14100 -3.81900  46.62400 1.000 34.18859  ? 87  ASP A HB2  1 
ATOM   641  H  HB3  . ASP A 1 87  ? 13.43300 -3.88800  45.20300 1.000 34.18859  ? 87  ASP A HB3  1 
ATOM   642  N  N    . ARG A 1 88  ? 15.88300 -1.56500  43.19700 1.000 27.01471  ? 88  ARG A N    1 
ATOM   643  C  CA   . ARG A 1 88  ? 16.13100 -1.40400  41.77200 1.000 27.27225  ? 88  ARG A CA   1 
ATOM   644  C  C    . ARG A 1 88  ? 17.26400 -0.40500  41.58700 1.000 30.66499  ? 88  ARG A C    1 
ATOM   645  O  O    . ARG A 1 88  ? 17.56800 0.38900   42.48100 1.000 28.22540  ? 88  ARG A O    1 
ATOM   646  C  CB   . ARG A 1 88  ? 14.87900 -0.92400  41.03200 1.000 31.07401  ? 88  ARG A CB   1 
ATOM   647  C  CG   . ARG A 1 88  ? 14.55700 0.53100   41.30800 1.000 32.75031  ? 88  ARG A CG   1 
ATOM   648  C  CD   . ARG A 1 88  ? 13.12600 0.89100   40.96200 1.000 35.17093  ? 88  ARG A CD   1 
ATOM   649  N  NE   . ARG A 1 88  ? 12.91900 1.01000   39.52300 1.000 35.91176  ? 88  ARG A NE   1 
ATOM   650  C  CZ   . ARG A 1 88  ? 11.79700 1.44300   38.96400 1.000 47.10738  ? 88  ARG A CZ   1 
ATOM   651  N  NH1  . ARG A 1 88  ? 10.76000 1.82000   39.69500 1.000 56.83278  ? 88  ARG A NH1  1 
ATOM   652  N  NH2  . ARG A 1 88  ? 11.71600 1.50900   37.63800 1.000 52.81205  ? 88  ARG A NH2  1 
ATOM   653  H  H    . ARG A 1 88  ? 16.17900 -0.91400  43.67400 1.000 32.35741  ? 88  ARG A H    1 
ATOM   654  H  HA   . ARG A 1 88  ? 16.40200 -2.25600  41.39700 1.000 32.66646  ? 88  ARG A HA   1 
ATOM   655  H  HB2  . ARG A 1 88  ? 15.01800 -1.02500  40.07700 1.000 37.22857  ? 88  ARG A HB2  1 
ATOM   656  H  HB3  . ARG A 1 88  ? 14.12100 -1.45900  41.31500 1.000 37.22857  ? 88  ARG A HB3  1 
ATOM   657  H  HG2  . ARG A 1 88  ? 14.69200 0.71100   42.25100 1.000 39.24014  ? 88  ARG A HG2  1 
ATOM   658  H  HG3  . ARG A 1 88  ? 15.14400 1.09100   40.77600 1.000 39.24014  ? 88  ARG A HG3  1 
ATOM   659  H  HD2  . ARG A 1 88  ? 12.53400 0.19900   41.29600 1.000 42.14488  ? 88  ARG A HD2  1 
ATOM   660  H  HD3  . ARG A 1 88  ? 12.90400 1.74200   41.37000 1.000 42.14488  ? 88  ARG A HD3  1 
ATOM   661  H  HE   . ARG A 1 88  ? 13.56600 0.78400   39.00400 1.000 43.03388  ? 88  ARG A HE   1 
ATOM   662  H  HH11 . ARG A 1 88  ? 10.80400 1.78700   40.55300 1.000 68.13910  ? 88  ARG A HH11 1 
ATOM   663  H  HH12 . ARG A 1 88  ? 10.04200 2.09700   39.31200 1.000 68.13910  ? 88  ARG A HH12 1 
ATOM   664  H  HH21 . ARG A 1 88  ? 12.38700 1.27300   37.15400 1.000 63.31423  ? 88  ARG A HH21 1 
ATOM   665  H  HH22 . ARG A 1 88  ? 10.99400 1.78900   37.26400 1.000 63.31423  ? 88  ARG A HH22 1 
ATOM   666  N  N    . ASN A 1 89  ? 17.87700 -0.44600  40.40800 1.000 25.85770  ? 89  ASN A N    1 
ATOM   667  C  CA   . ASN A 1 89  ? 18.96800 0.45700   40.08000 1.000 27.08754  ? 89  ASN A CA   1 
ATOM   668  C  C    . ASN A 1 89  ? 18.41400 1.76100   39.52200 1.000 26.28429  ? 89  ASN A C    1 
ATOM   669  O  O    . ASN A 1 89  ? 17.40900 1.77000   38.80700 1.000 23.48379  ? 89  ASN A O    1 
ATOM   670  C  CB   . ASN A 1 89  ? 19.92200 -0.18600  39.07200 1.000 25.07652  ? 89  ASN A CB   1 
ATOM   671  C  CG   . ASN A 1 89  ? 20.54500 -1.46300  39.60100 1.000 34.99799  ? 89  ASN A CG   1 
ATOM   672  O  OD1  . ASN A 1 89  ? 20.76800 -1.60500  40.80500 1.000 30.29779  ? 89  ASN A OD1  1 
ATOM   673  N  ND2  . ASN A 1 89  ? 20.83500 -2.39800  38.70400 1.000 32.02707  ? 89  ASN A ND2  1 
ATOM   674  H  H    . ASN A 1 89  ? 17.67500 -0.99400  39.77700 1.000 30.96900  ? 89  ASN A H    1 
ATOM   675  H  HA   . ASN A 1 89  ? 19.47500 0.65800   40.88200 1.000 32.44481  ? 89  ASN A HA   1 
ATOM   676  H  HB2  . ASN A 1 89  ? 19.43100 -0.40200  38.26400 1.000 30.03159  ? 89  ASN A HB2  1 
ATOM   677  H  HB3  . ASN A 1 89  ? 20.63700 0.43700   38.87000 1.000 30.03159  ? 89  ASN A HB3  1 
ATOM   678  H  HD21 . ASN A 1 89  ? 20.66800 -2.26100  37.87200 1.000 38.37225  ? 89  ASN A HD21 1 
ATOM   679  H  HD22 . ASN A 1 89  ? 21.19000 -3.14000  38.95500 1.000 38.37225  ? 89  ASN A HD22 1 
ATOM   680  N  N    . VAL A 1 90  ? 19.07800 2.86600   39.86000 1.000 24.80706  ? 90  VAL A N    1 
ATOM   681  C  CA   . VAL A 1 90  ? 18.62000 4.19800   39.49500 1.000 22.18426  ? 90  VAL A CA   1 
ATOM   682  C  C    . VAL A 1 90  ? 19.80400 5.00800   38.98900 1.000 25.66545  ? 90  VAL A C    1 
ATOM   683  O  O    . VAL A 1 90  ? 20.96600 4.65600   39.20100 1.000 25.66867  ? 90  VAL A O    1 
ATOM   684  C  CB   . VAL A 1 90  ? 17.95000 4.92900   40.68400 1.000 25.61724  ? 90  VAL A CB   1 
ATOM   685  C  CG1  . VAL A 1 90  ? 16.74900 4.14300   41.18700 1.000 29.35761  ? 90  VAL A CG1  1 
ATOM   686  C  CG2  . VAL A 1 90  ? 18.95400 5.15000   41.81200 1.000 24.75211  ? 90  VAL A CG2  1 
ATOM   687  H  H    . VAL A 1 90  ? 19.81100 2.86600   40.31000 1.000 29.70823  ? 90  VAL A H    1 
ATOM   688  H  HA   . VAL A 1 90  ? 17.97400 4.12500   38.77500 1.000 26.56087  ? 90  VAL A HA   1 
ATOM   689  H  HB   . VAL A 1 90  ? 17.63900 5.79600   40.38000 1.000 30.68045  ? 90  VAL A HB   1 
ATOM   690  H  HG11 . VAL A 1 90  ? 16.38500 4.58900   41.96800 1.000 35.16890  ? 90  VAL A HG11 1 
ATOM   691  H  HG12 . VAL A 1 90  ? 16.08000 4.10600   40.48600 1.000 35.16890  ? 90  VAL A HG12 1 
ATOM   692  H  HG13 . VAL A 1 90  ? 17.03400 3.24600   41.42100 1.000 35.16890  ? 90  VAL A HG13 1 
ATOM   693  H  HG21 . VAL A 1 90  ? 18.48000 5.45800   42.60000 1.000 29.64229  ? 90  VAL A HG21 1 
ATOM   694  H  HG22 . VAL A 1 90  ? 19.40300 4.31200   42.00300 1.000 29.64229  ? 90  VAL A HG22 1 
ATOM   695  H  HG23 . VAL A 1 90  ? 19.60100 5.81600   41.53200 1.000 29.64229  ? 90  VAL A HG23 1 
ATOM   696  N  N    . ALA A 1 91  ? 19.48900 6.10100   38.30000 1.000 20.65577  ? 91  ALA A N    1 
ATOM   697  C  CA   . ALA A 1 91  ? 20.46500 7.11500   37.93200 1.000 22.35547  ? 91  ALA A CA   1 
ATOM   698  C  C    . ALA A 1 91  ? 20.20400 8.36500   38.75900 1.000 21.64823  ? 91  ALA A C    1 
ATOM   699  O  O    . ALA A 1 91  ? 19.04900 8.76000   38.94400 1.000 20.41668  ? 91  ALA A O    1 
ATOM   700  C  CB   . ALA A 1 91  ? 20.39100 7.44500   36.43800 1.000 23.58257  ? 91  ALA A CB   1 
ATOM   701  H  H    . ALA A 1 91  ? 18.69300 6.28000   38.02800 1.000 24.72668  ? 91  ALA A H    1 
ATOM   702  H  HA   . ALA A 1 91  ? 21.36300 6.79600   38.11400 1.000 26.76633  ? 91  ALA A HA   1 
ATOM   703  H  HB1  . ALA A 1 91  ? 21.07100 8.10400   36.22700 1.000 28.23885  ? 91  ALA A HB1  1 
ATOM   704  H  HB2  . ALA A 1 91  ? 20.54500 6.63500   35.92800 1.000 28.23885  ? 91  ALA A HB2  1 
ATOM   705  H  HB3  . ALA A 1 91  ? 19.51100 7.80100   36.23700 1.000 28.23885  ? 91  ALA A HB3  1 
ATOM   706  N  N    . ILE A 1 92  ? 21.27500 8.97800   39.25800 1.000 18.53210  ? 92  ILE A N    1 
ATOM   707  C  CA   . ILE A 1 92  ? 21.19300 10.15600  40.11900 1.000 22.17271  ? 92  ILE A CA   1 
ATOM   708  C  C    . ILE A 1 92  ? 21.99400 11.27500  39.47300 1.000 22.65964  ? 92  ILE A C    1 
ATOM   709  O  O    . ILE A 1 92  ? 23.19200 11.11700  39.21300 1.000 24.40327  ? 92  ILE A O    1 
ATOM   710  C  CB   . ILE A 1 92  ? 21.71300 9.86700   41.53800 1.000 19.32699  ? 92  ILE A CB   1 
ATOM   711  C  CG1  . ILE A 1 92  ? 20.84000 8.81300   42.21700 1.000 22.03165  ? 92  ILE A CG1  1 
ATOM   712  C  CG2  . ILE A 1 92  ? 21.74100 11.14200  42.38100 1.000 18.84151  ? 92  ILE A CG2  1 
ATOM   713  C  CD1  . ILE A 1 92  ? 21.51500 8.13300   43.40100 1.000 23.76401  ? 92  ILE A CD1  1 
ATOM   714  H  H    . ILE A 1 92  ? 22.08300 8.72400   39.10600 1.000 22.17828  ? 92  ILE A H    1 
ATOM   715  H  HA   . ILE A 1 92  ? 20.26600 10.43700  40.18100 1.000 26.54701  ? 92  ILE A HA   1 
ATOM   716  H  HB   . ILE A 1 92  ? 22.61900 9.52900   41.46000 1.000 23.13215  ? 92  ILE A HB   1 
ATOM   717  H  HG12 . ILE A 1 92  ? 20.03100 9.23900   42.54100 1.000 26.37774  ? 92  ILE A HG12 1 
ATOM   718  H  HG13 . ILE A 1 92  ? 20.61700 8.12700   41.56800 1.000 26.37774  ? 92  ILE A HG13 1 
ATOM   719  H  HG21 . ILE A 1 92  ? 22.05600 10.92400  43.27200 1.000 22.54957  ? 92  ILE A HG21 1 
ATOM   720  H  HG22 . ILE A 1 92  ? 22.34100 11.78200  41.96500 1.000 22.54957  ? 92  ILE A HG22 1 
ATOM   721  H  HG23 . ILE A 1 92  ? 20.84500 11.51000  42.42700 1.000 22.54957  ? 92  ILE A HG23 1 
ATOM   722  H  HD11 . ILE A 1 92  ? 20.90700 7.47700   43.77700 1.000 28.45657  ? 92  ILE A HD11 1 
ATOM   723  H  HD12 . ILE A 1 92  ? 22.32400 7.69500   43.09400 1.000 28.45657  ? 92  ILE A HD12 1 
ATOM   724  H  HD13 . ILE A 1 92  ? 21.73300 8.80200   44.06800 1.000 28.45657  ? 92  ILE A HD13 1 
ATOM   725  N  N    . LYS A 1 93  ? 21.33600 12.40700  39.23300 1.000 25.21766  ? 93  LYS A N    1 
ATOM   726  C  CA   . LYS A 1 93  ? 21.95100 13.58100  38.62500 1.000 27.19191  ? 93  LYS A CA   1 
ATOM   727  C  C    . LYS A 1 93  ? 22.02500 14.69600  39.65800 1.000 20.96318  ? 93  LYS A C    1 
ATOM   728  O  O    . LYS A 1 93  ? 21.02500 15.01100  40.31100 1.000 21.89758  ? 93  LYS A O    1 
ATOM   729  C  CB   . LYS A 1 93  ? 21.15300 14.03500  37.39900 1.000 22.79751  ? 93  LYS A CB   1 
ATOM   730  C  CG   . LYS A 1 93  ? 21.73200 15.21600  36.61500 1.000 32.37862  ? 93  LYS A CG   1 
ATOM   731  C  CD   . LYS A 1 93  ? 20.89200 15.44000  35.35200 1.000 29.67552  ? 93  LYS A CD   1 
ATOM   732  C  CE   . LYS A 1 93  ? 21.26000 16.70300  34.59600 1.000 50.75057  ? 93  LYS A CE   1 
ATOM   733  N  NZ   . LYS A 1 93  ? 20.35400 16.88600  33.42100 1.000 38.98175  ? 93  LYS A NZ   1 
ATOM   734  H  H    . LYS A 1 93  ? 20.50400 12.52100  39.41900 1.000 30.20095  ? 93  LYS A H    1 
ATOM   735  H  HA   . LYS A 1 93  ? 22.85500 13.37400  38.33900 1.000 32.57006  ? 93  LYS A HA   1 
ATOM   736  H  HB2  . LYS A 1 93  ? 21.09100 13.28600  36.78500 1.000 27.29678  ? 93  LYS A HB2  1 
ATOM   737  H  HB3  . LYS A 1 93  ? 20.26600 14.29500  37.69500 1.000 27.29678  ? 93  LYS A HB3  1 
ATOM   738  H  HG2  . LYS A 1 93  ? 21.70300 16.01900  37.15900 1.000 38.79410  ? 93  LYS A HG2  1 
ATOM   739  H  HG3  . LYS A 1 93  ? 22.64600 15.02300  36.35500 1.000 38.79410  ? 93  LYS A HG3  1 
ATOM   740  H  HD2  . LYS A 1 93  ? 21.02000 14.68800  34.75300 1.000 35.55038  ? 93  LYS A HD2  1 
ATOM   741  H  HD3  . LYS A 1 93  ? 19.95800 15.50700  35.60500 1.000 35.55038  ? 93  LYS A HD3  1 
ATOM   742  H  HE2  . LYS A 1 93  ? 21.16900 17.47100  35.18100 1.000 60.84044  ? 93  LYS A HE2  1 
ATOM   743  H  HE3  . LYS A 1 93  ? 22.17300 16.63600  34.27600 1.000 60.84044  ? 93  LYS A HE3  1 
ATOM   744  H  HZ1  . LYS A 1 93  ? 20.57200 17.62800  32.98100 1.000 46.71787  ? 93  LYS A HZ1  1 
ATOM   745  H  HZ2  . LYS A 1 93  ? 20.42600 16.19100  32.87000 1.000 46.71787  ? 93  LYS A HZ2  1 
ATOM   746  H  HZ3  . LYS A 1 93  ? 19.51000 16.95100  33.69600 1.000 46.71787  ? 93  LYS A HZ3  1 
ATOM   747  N  N    . LYS A 1 94  ? 23.21100 15.28100  39.80600 1.000 21.42365  ? 94  LYS A N    1 
ATOM   748  C  CA   . LYS A 1 94  ? 23.44700 16.37600  40.73800 1.000 23.81119  ? 94  LYS A CA   1 
ATOM   749  C  C    . LYS A 1 94  ? 23.42600 17.69700  39.98300 1.000 26.84996  ? 94  LYS A C    1 
ATOM   750  O  O    . LYS A 1 94  ? 24.22800 17.90100  39.06700 1.000 25.65968  ? 94  LYS A O    1 
ATOM   751  C  CB   . LYS A 1 94  ? 24.79000 16.20800  41.44700 1.000 29.08464  ? 94  LYS A CB   1 
ATOM   752  C  CG   . LYS A 1 94  ? 25.15400 17.37300  42.36100 1.000 30.41371  ? 94  LYS A CG   1 
ATOM   753  C  CD   . LYS A 1 94  ? 26.46300 17.12300  43.09100 1.000 36.11233  ? 94  LYS A CD   1 
ATOM   754  C  CE   . LYS A 1 94  ? 26.78700 18.25300  44.05700 1.000 35.95406  ? 94  LYS A CE   1 
ATOM   755  N  NZ   . LYS A 1 94  ? 28.20000 18.19300  44.51900 1.000 38.25608  ? 94  LYS A NZ   1 
ATOM   756  H  H    . LYS A 1 94  ? 23.91300 15.05400  39.36500 1.000 25.64814  ? 94  LYS A H    1 
ATOM   757  H  HA   . LYS A 1 94  ? 22.73800 16.38200  41.40100 1.000 28.51319  ? 94  LYS A HA   1 
ATOM   758  H  HB2  . LYS A 1 94  ? 24.75800 15.40500  41.99100 1.000 34.84132  ? 94  LYS A HB2  1 
ATOM   759  H  HB3  . LYS A 1 94  ? 25.48800 16.12800  40.77800 1.000 34.84132  ? 94  LYS A HB3  1 
ATOM   760  H  HG2  . LYS A 1 94  ? 25.25100 18.17900  41.83000 1.000 36.43621  ? 94  LYS A HG2  1 
ATOM   761  H  HG3  . LYS A 1 94  ? 24.45500 17.49200  43.02200 1.000 36.43621  ? 94  LYS A HG3  1 
ATOM   762  H  HD2  . LYS A 1 94  ? 26.39600 16.29900  43.59800 1.000 43.27455  ? 94  LYS A HD2  1 
ATOM   763  H  HD3  . LYS A 1 94  ? 27.18300 17.05800  42.44500 1.000 43.27455  ? 94  LYS A HD3  1 
ATOM   764  H  HE2  . LYS A 1 94  ? 26.64900 19.10400  43.61200 1.000 43.08464  ? 94  LYS A HE2  1 
ATOM   765  H  HE3  . LYS A 1 94  ? 26.21000 18.18700  44.83300 1.000 43.08464  ? 94  LYS A HE3  1 
ATOM   766  H  HZ1  . LYS A 1 94  ? 28.75100 18.22600  43.82100 1.000 45.84706  ? 94  LYS A HZ1  1 
ATOM   767  H  HZ2  . LYS A 1 94  ? 28.37400 18.88000  45.05700 1.000 45.84706  ? 94  LYS A HZ2  1 
ATOM   768  H  HZ3  . LYS A 1 94  ? 28.34300 17.43500  44.96300 1.000 45.84706  ? 94  LYS A HZ3  1 
ATOM   769  N  N    . LEU A 1 95  ? 22.52400 18.59300  40.37600 1.000 27.95996  ? 95  LEU A N    1 
ATOM   770  C  CA   . LEU A 1 95  ? 22.52800 19.97400  39.89800 1.000 32.12429  ? 95  LEU A CA   1 
ATOM   771  C  C    . LEU A 1 95  ? 23.24900 20.82600  40.93900 1.000 25.71784  ? 95  LEU A C    1 
ATOM   772  O  O    . LEU A 1 95  ? 22.72100 21.06000  42.03300 1.000 25.75724  ? 95  LEU A O    1 
ATOM   773  C  CB   . LEU A 1 95  ? 21.11100 20.48700  39.66300 1.000 25.39896  ? 95  LEU A CB   1 
ATOM   774  C  CG   . LEU A 1 95  ? 20.18000 19.63100  38.80500 1.000 30.54617  ? 95  LEU A CG   1 
ATOM   775  C  CD1  . LEU A 1 95  ? 18.87000 20.37200  38.56800 1.000 31.09493  ? 95  LEU A CD1  1 
ATOM   776  C  CD2  . LEU A 1 95  ? 20.84300 19.27000  37.49300 1.000 34.12400  ? 95  LEU A CD2  1 
ATOM   777  H  H    . LEU A 1 95  ? 21.88800 18.42100  40.92800 1.000 33.49171  ? 95  LEU A H    1 
ATOM   778  H  HA   . LEU A 1 95  ? 23.00700 20.02200  39.05600 1.000 38.48891  ? 95  LEU A HA   1 
ATOM   779  H  HB2  . LEU A 1 95  ? 20.68300 20.58500  40.52800 1.000 30.41851  ? 95  LEU A HB2  1 
ATOM   780  H  HB3  . LEU A 1 95  ? 21.17700 21.35100  39.22700 1.000 30.41851  ? 95  LEU A HB3  1 
ATOM   781  H  HG   . LEU A 1 95  ? 19.98300 18.80200  39.27000 1.000 36.59517  ? 95  LEU A HG   1 
ATOM   782  H  HD11 . LEU A 1 95  ? 18.33000 19.86600  37.94100 1.000 37.25367  ? 95  LEU A HD11 1 
ATOM   783  H  HD12 . LEU A 1 95  ? 18.40000 20.46200  39.41200 1.000 37.25367  ? 95  LEU A HD12 1 
ATOM   784  H  HD13 . LEU A 1 95  ? 19.06500 21.24900  38.20300 1.000 37.25367  ? 95  LEU A HD13 1 
ATOM   785  H  HD21 . LEU A 1 95  ? 20.18400 18.86600  36.90800 1.000 40.88857  ? 95  LEU A HD21 1 
ATOM   786  H  HD22 . LEU A 1 95  ? 21.19600 20.07700  37.08600 1.000 40.88857  ? 95  LEU A HD22 1 
ATOM   787  H  HD23 . LEU A 1 95  ? 21.56200 18.64300  37.66500 1.000 40.88857  ? 95  LEU A HD23 1 
ATOM   788  N  N    . SER A 1 96  ? 24.44800 21.29100  40.59900 1.000 28.99308  ? 96  SER A N    1 
ATOM   789  C  CA   . SER A 1 96  ? 25.27700 22.06100  41.52100 1.000 30.72648  ? 96  SER A CA   1 
ATOM   790  C  C    . SER A 1 96  ? 24.91700 23.53900  41.40900 1.000 33.84398  ? 96  SER A C    1 
ATOM   791  O  O    . SER A 1 96  ? 25.14400 24.16200  40.36400 1.000 26.49515  ? 96  SER A O    1 
ATOM   792  C  CB   . SER A 1 96  ? 26.75800 21.83500  41.22200 1.000 33.66777  ? 96  SER A CB   1 
ATOM   793  O  OG   . SER A 1 96  ? 27.10500 20.47200  41.40400 1.000 46.49083  ? 96  SER A OG   1 
ATOM   794  H  H    . SER A 1 96  ? 24.80900 21.17100  39.82800 1.000 34.73146  ? 96  SER A H    1 
ATOM   795  H  HA   . SER A 1 96  ? 25.10300 21.77600  42.43100 1.000 36.81154  ? 96  SER A HA   1 
ATOM   796  H  HB2  . SER A 1 96  ? 26.93700 22.08700  40.30300 1.000 40.34109  ? 96  SER A HB2  1 
ATOM   797  H  HB3  . SER A 1 96  ? 27.28800 22.37900  41.82500 1.000 40.34109  ? 96  SER A HB3  1 
ATOM   798  H  HG   . SER A 1 96  ? 27.91600 20.35500  41.21900 1.000 55.72876  ? 96  SER A HG   1 
ATOM   799  N  N    . ARG A 1 97  ? 24.37800 24.09900  42.49700 1.000 34.34003  ? 97  ARG A N    1 
ATOM   800  C  CA   . ARG A 1 97  ? 23.75300 25.42100  42.52800 1.000 39.34284  ? 97  ARG A CA   1 
ATOM   801  C  C    . ARG A 1 97  ? 23.17800 25.79200  41.16100 1.000 34.34191  ? 97  ARG A C    1 
ATOM   802  O  O    . ARG A 1 97  ? 23.77500 26.58100  40.41700 1.000 33.42388  ? 97  ARG A O    1 
ATOM   803  C  CB   . ARG A 1 97  ? 24.73300 26.49800  42.99600 1.000 39.20357  ? 97  ARG A CB   1 
ATOM   804  C  CG   . ARG A 1 97  ? 25.92600 26.01400  43.79500 1.000 48.05429  ? 97  ARG A CG   1 
ATOM   805  C  CD   . ARG A 1 97  ? 26.56900 27.21900  44.46100 1.000 52.82899  ? 97  ARG A CD   1 
ATOM   806  N  NE   . ARG A 1 97  ? 26.01700 27.42700  45.79500 1.000 65.39236  ? 97  ARG A NE   1 
ATOM   807  C  CZ   . ARG A 1 97  ? 25.70000 28.60500  46.31900 1.000 62.16528  ? 97  ARG A CZ   1 
ATOM   808  N  NH1  . ARG A 1 97  ? 25.78700 29.72400  45.61900 1.000 59.93571  ? 97  ARG A NH1  1 
ATOM   809  N  NH2  . ARG A 1 97  ? 25.27000 28.65900  47.57700 1.000 59.30966  ? 97  ARG A NH2  1 
ATOM   810  H  H    . ARG A 1 97  ? 24.36200 23.71400  43.26500 1.000 41.14780  ? 97  ARG A H    1 
ATOM   811  H  HA   . ARG A 1 97  ? 23.02000 25.38500  43.16200 1.000 47.15117  ? 97  ARG A HA   1 
ATOM   812  H  HB2  . ARG A 1 97  ? 25.08000 26.95400  42.21300 1.000 46.98405  ? 97  ARG A HB2  1 
ATOM   813  H  HB3  . ARG A 1 97  ? 24.24900 27.12500  43.55700 1.000 46.98405  ? 97  ARG A HB3  1 
ATOM   814  H  HG2  . ARG A 1 97  ? 25.63900 25.38800  44.47800 1.000 57.60491  ? 97  ARG A HG2  1 
ATOM   815  H  HG3  . ARG A 1 97  ? 26.57200 25.59200  43.20800 1.000 57.60491  ? 97  ARG A HG3  1 
ATOM   816  H  HD2  . ARG A 1 97  ? 27.52400 27.07300  44.54200 1.000 63.33455  ? 97  ARG A HD2  1 
ATOM   817  H  HD3  . ARG A 1 97  ? 26.39800 28.01200  43.92900 1.000 63.33455  ? 97  ARG A HD3  1 
ATOM   818  H  HE   . ARG A 1 97  ? 25.88600 26.73000  46.28100 1.000 78.41059  ? 97  ARG A HE   1 
ATOM   819  H  HH11 . ARG A 1 97  ? 26.05500 29.70100  44.80200 1.000 71.86261  ? 97  ARG A HH11 1 
ATOM   820  H  HH12 . ARG A 1 97  ? 25.57700 30.47500  45.98100 1.000 71.86261  ? 97  ARG A HH12 1 
ATOM   821  H  HH21 . ARG A 1 97  ? 25.19900 27.93700  48.03800 1.000 71.11136  ? 97  ARG A HH21 1 
ATOM   822  H  HH22 . ARG A 1 97  ? 25.06100 29.41600  47.92800 1.000 71.11136  ? 97  ARG A HH22 1 
ATOM   823  N  N    . PRO A 1 98  ? 22.01000 25.25000  40.81100 1.000 28.09789  ? 98  PRO A N    1 
ATOM   824  C  CA   . PRO A 1 98  ? 21.40200 25.58700  39.51500 1.000 29.58346  ? 98  PRO A CA   1 
ATOM   825  C  C    . PRO A 1 98  ? 21.05500 27.05600  39.37800 1.000 29.67293  ? 98  PRO A C    1 
ATOM   826  O  O    . PRO A 1 98  ? 20.87800 27.53800  38.25100 1.000 31.26465  ? 98  PRO A O    1 
ATOM   827  C  CB   . PRO A 1 98  ? 20.14100 24.71200  39.47900 1.000 28.20377  ? 98  PRO A CB   1 
ATOM   828  C  CG   . PRO A 1 98  ? 19.85100 24.38800  40.90900 1.000 30.06252  ? 98  PRO A CG   1 
ATOM   829  C  CD   . PRO A 1 98  ? 21.17400 24.32900  41.60300 1.000 25.70545  ? 98  PRO A CD   1 
ATOM   830  H  HA   . PRO A 1 98  ? 21.99400 25.32600  38.79200 1.000 35.43991  ? 98  PRO A HA   1 
ATOM   831  H  HB2  . PRO A 1 98  ? 19.40900 25.20700  39.08000 1.000 33.78429  ? 98  PRO A HB2  1 
ATOM   832  H  HB3  . PRO A 1 98  ? 20.31400 23.90600  38.96800 1.000 33.78429  ? 98  PRO A HB3  1 
ATOM   833  H  HG2  . PRO A 1 98  ? 19.29400 25.08300  41.29400 1.000 36.01479  ? 98  PRO A HG2  1 
ATOM   834  H  HG3  . PRO A 1 98  ? 19.39800 23.53200  40.96300 1.000 36.01479  ? 98  PRO A HG3  1 
ATOM   835  H  HD2  . PRO A 1 98  ? 21.09600 24.63400  42.52100 1.000 30.78631  ? 98  PRO A HD2  1 
ATOM   836  H  HD3  . PRO A 1 98  ? 21.53500 23.42900  41.58300 1.000 30.78631  ? 98  PRO A HD3  1 
ATOM   837  N  N    . PHE A 1 99  ? 20.95000 27.78000  40.48700 1.000 27.35145  ? 99  PHE A N    1 
ATOM   838  C  CA   . PHE A 1 99  ? 20.55100 29.18100  40.49200 1.000 26.79647  ? 99  PHE A CA   1 
ATOM   839  C  C    . PHE A 1 99  ? 21.71500 30.12900  40.24900 1.000 29.55582  ? 99  PHE A C    1 
ATOM   840  O  O    . PHE A 1 99  ? 21.51600 31.34800  40.26700 1.000 32.63623  ? 99  PHE A O    1 
ATOM   841  C  CB   . PHE A 1 99  ? 19.89200 29.52800  41.83200 1.000 28.62599  ? 99  PHE A CB   1 
ATOM   842  C  CG   . PHE A 1 99  ? 20.63200 28.98800  43.02300 1.000 34.14566  ? 99  PHE A CG   1 
ATOM   843  C  CD1  . PHE A 1 99  ? 21.69600 29.68400  43.56400 1.000 36.79021  ? 99  PHE A CD1  1 
ATOM   844  C  CD2  . PHE A 1 99  ? 20.27500 27.77300  43.58600 1.000 33.35918  ? 99  PHE A CD2  1 
ATOM   845  C  CE1  . PHE A 1 99  ? 22.38700 29.18600  44.65000 1.000 44.66506  ? 99  PHE A CE1  1 
ATOM   846  C  CE2  . PHE A 1 99  ? 20.96300 27.26900  44.67100 1.000 30.29811  ? 99  PHE A CE2  1 
ATOM   847  C  CZ   . PHE A 1 99  ? 22.02000 27.97600  45.20400 1.000 42.10123  ? 99  PHE A CZ   1 
ATOM   848  H  H    . PHE A 1 99  ? 21.10900 27.47100  41.27400 1.000 32.76150  ? 99  PHE A H    1 
ATOM   849  H  HA   . PHE A 1 99  ? 19.90200 29.31800  39.78500 1.000 32.09552  ? 99  PHE A HA   1 
ATOM   850  H  HB2  . PHE A 1 99  ? 19.85200 30.49300  41.92000 1.000 34.29095  ? 99  PHE A HB2  1 
ATOM   851  H  HB3  . PHE A 1 99  ? 18.99600 29.15600  41.84500 1.000 34.29095  ? 99  PHE A HB3  1 
ATOM   852  H  HD1  . PHE A 1 99  ? 21.95000 30.49800  43.19200 1.000 44.08801  ? 99  PHE A HD1  1 
ATOM   853  H  HD2  . PHE A 1 99  ? 19.56400 27.29100  43.22900 1.000 39.97078  ? 99  PHE A HD2  1 
ATOM   854  H  HE1  . PHE A 1 99  ? 23.09900 29.66600  45.00900 1.000 53.53783  ? 99  PHE A HE1  1 
ATOM   855  H  HE2  . PHE A 1 99  ? 20.71400 26.45300  45.04200 1.000 36.29749  ? 99  PHE A HE2  1 
ATOM   856  H  HZ   . PHE A 1 99  ? 22.48500 27.63900  45.93600 1.000 50.46124  ? 99  PHE A HZ   1 
ATOM   857  N  N    . GLN A 1 100 ? 22.92000 29.60200  40.02100 1.000 27.08907  ? 100 GLN A N    1 
ATOM   858  C  CA   . GLN A 1 100 ? 24.10400 30.44800  39.92700 1.000 35.31930  ? 100 GLN A CA   1 
ATOM   859  C  C    . GLN A 1 100 ? 24.04600 31.41800  38.75100 1.000 39.70869  ? 100 GLN A C    1 
ATOM   860  O  O    . GLN A 1 100 ? 24.71700 32.45600  38.79100 1.000 33.48379  ? 100 GLN A O    1 
ATOM   861  C  CB   . GLN A 1 100 ? 25.35200 29.57000  39.82900 1.000 31.03688  ? 100 GLN A CB   1 
ATOM   862  C  CG   . GLN A 1 100 ? 25.44600 28.75800  38.55200 1.000 35.41710  ? 100 GLN A CG   1 
ATOM   863  C  CD   . GLN A 1 100 ? 26.57300 27.74800  38.60300 1.000 47.50876  ? 100 GLN A CD   1 
ATOM   864  O  OE1  . GLN A 1 100 ? 26.37400 26.59700  38.99600 1.000 45.96080  ? 100 GLN A OE1  1 
ATOM   865  N  NE2  . GLN A 1 100 ? 27.76700 28.17300  38.20700 1.000 43.00083  ? 100 GLN A NE2  1 
ATOM   866  H  H    . GLN A 1 100 ? 23.07600 28.76300  39.91900 1.000 32.44665  ? 100 GLN A H    1 
ATOM   867  H  HA   . GLN A 1 100 ? 24.16900 30.98300  40.73300 1.000 42.32292  ? 100 GLN A HA   1 
ATOM   868  H  HB2  . GLN A 1 100 ? 26.13600 30.14000  39.87300 1.000 37.18402  ? 100 GLN A HB2  1 
ATOM   869  H  HB3  . GLN A 1 100 ? 25.35300 28.94800  40.57400 1.000 37.18402  ? 100 GLN A HB3  1 
ATOM   870  H  HG2  . GLN A 1 100 ? 24.61400 28.27700  38.41800 1.000 42.44029  ? 100 GLN A HG2  1 
ATOM   871  H  HG3  . GLN A 1 100 ? 25.60800 29.35500  37.80500 1.000 42.44029  ? 100 GLN A HG3  1 
ATOM   872  H  HE21 . GLN A 1 100 ? 27.86800 28.98500  37.94000 1.000 51.54075  ? 100 GLN A HE21 1 
ATOM   873  H  HE22 . GLN A 1 100 ? 28.44000 27.63800  38.21700 1.000 51.54075  ? 100 GLN A HE22 1 
ATOM   874  N  N    . ASN A 1 101 ? 23.27300 31.11800  37.71100 1.000 32.40029  ? 101 ASN A N    1 
ATOM   875  C  CA   . ASN A 1 101 ? 23.09700 32.07400  36.62300 1.000 34.97554  ? 101 ASN A CA   1 
ATOM   876  C  C    . ASN A 1 101 ? 21.82400 31.74000  35.86100 1.000 46.34346  ? 101 ASN A C    1 
ATOM   877  O  O    . ASN A 1 101 ? 21.19100 30.70300  36.07800 1.000 30.37114  ? 101 ASN A O    1 
ATOM   878  C  CB   . ASN A 1 101 ? 24.31100 32.10100  35.68500 1.000 38.57206  ? 101 ASN A CB   1 
ATOM   879  C  CG   . ASN A 1 101 ? 24.53500 30.78300  34.97100 1.000 39.72358  ? 101 ASN A CG   1 
ATOM   880  O  OD1  . ASN A 1 101 ? 23.64300 30.26300  34.30400 1.000 46.77670  ? 101 ASN A OD1  1 
ATOM   881  N  ND2  . ASN A 1 101 ? 25.74100 30.24300  35.09600 1.000 46.63335  ? 101 ASN A ND2  1 
ATOM   882  H  H    . ASN A 1 101 ? 22.84700 30.37800  37.61300 1.000 38.82011  ? 101 ASN A H    1 
ATOM   883  H  HA   . ASN A 1 101 ? 22.99000 32.95800  37.00800 1.000 41.91040  ? 101 ASN A HA   1 
ATOM   884  H  HB2  . ASN A 1 101 ? 24.17400 32.78700  35.01200 1.000 46.22623  ? 101 ASN A HB2  1 
ATOM   885  H  HB3  . ASN A 1 101 ? 25.10600 32.30000  36.20300 1.000 46.22623  ? 101 ASN A HB3  1 
ATOM   886  H  HD21 . ASN A 1 101 ? 25.92000 29.49500  34.71100 1.000 55.89978  ? 101 ASN A HD21 1 
ATOM   887  H  HD22 . ASN A 1 101 ? 26.34400 30.64000  35.56300 1.000 55.89978  ? 101 ASN A HD22 1 
ATOM   888  N  N    . GLN A 1 102 ? 21.47200 32.64000  34.94200 1.000 43.43467  ? 102 GLN A N    1 
ATOM   889  C  CA   . GLN A 1 102 ? 20.17200 32.58200  34.28400 1.000 41.91400  ? 102 GLN A CA   1 
ATOM   890  C  C    . GLN A 1 102 ? 20.00800 31.31000  33.46900 1.000 41.41094  ? 102 GLN A C    1 
ATOM   891  O  O    . GLN A 1 102 ? 18.94700 30.67600  33.49700 1.000 41.69026  ? 102 GLN A O    1 
ATOM   892  C  CB   . GLN A 1 102 ? 19.99900 33.80800  33.38900 1.000 55.18661  ? 102 GLN A CB   1 
ATOM   893  C  CG   . GLN A 1 102 ? 19.54300 35.03700  34.13600 1.000 56.23491  ? 102 GLN A CG   1 
ATOM   894  C  CD   . GLN A 1 102 ? 18.06400 35.02600  34.42100 1.000 59.05529  ? 102 GLN A CD   1 
ATOM   895  O  OE1  . GLN A 1 102 ? 17.29400 34.31500  33.77500 1.000 69.95509  ? 102 GLN A OE1  1 
ATOM   896  N  NE2  . GLN A 1 102 ? 17.65800 35.80800  35.40600 1.000 62.60711  ? 102 GLN A NE2  1 
ATOM   897  H  H    . GLN A 1 102 ? 21.96800 33.29300  34.68200 1.000 52.06137  ? 102 GLN A H    1 
ATOM   898  H  HA   . GLN A 1 102 ? 19.47900 32.58900  34.96400 1.000 50.23656  ? 102 GLN A HA   1 
ATOM   899  H  HB2  . GLN A 1 102 ? 20.85000 34.01300  32.97100 1.000 66.16370  ? 102 GLN A HB2  1 
ATOM   900  H  HB3  . GLN A 1 102 ? 19.33500 33.60900  32.71000 1.000 66.16370  ? 102 GLN A HB3  1 
ATOM   901  H  HG2  . GLN A 1 102 ? 20.01200 35.08400  34.98400 1.000 67.42165  ? 102 GLN A HG2  1 
ATOM   902  H  HG3  . GLN A 1 102 ? 19.74000 35.82300  33.60400 1.000 67.42165  ? 102 GLN A HG3  1 
ATOM   903  H  HE21 . GLN A 1 102 ? 18.22800 36.28300  35.84000 1.000 75.06830  ? 102 GLN A HE21 1 
ATOM   904  H  HE22 . GLN A 1 102 ? 16.82400 35.84100  35.61200 1.000 75.06830  ? 102 GLN A HE22 1 
ATOM   905  N  N    . THR A 1 103 ? 21.04300 30.92400  32.72400 1.000 34.90358  ? 103 THR A N    1 
ATOM   906  C  CA   . THR A 1 103 ? 20.92600 29.76500  31.84800 1.000 39.64374  ? 103 THR A CA   1 
ATOM   907  C  C    . THR A 1 103 ? 20.69800 28.49200  32.65600 1.000 35.91351  ? 103 THR A C    1 
ATOM   908  O  O    . THR A 1 103 ? 19.78500 27.71200  32.36600 1.000 37.38760  ? 103 THR A O    1 
ATOM   909  C  CB   . THR A 1 103 ? 22.17600 29.64700  30.97500 1.000 43.87971  ? 103 THR A CB   1 
ATOM   910  O  OG1  . THR A 1 103 ? 22.29800 30.81700  30.15600 1.000 52.03451  ? 103 THR A OG1  1 
ATOM   911  C  CG2  . THR A 1 103 ? 22.09000 28.42500  30.07500 1.000 38.88754  ? 103 THR A CG2  1 
ATOM   912  H  H    . THR A 1 103 ? 21.81100 31.31100  32.70900 1.000 41.82406  ? 103 THR A H    1 
ATOM   913  H  HA   . THR A 1 103 ? 20.16300 29.88400  31.26100 1.000 47.51226  ? 103 THR A HA   1 
ATOM   914  H  HB   . THR A 1 103 ? 22.95700 29.55700  31.54300 1.000 52.59541  ? 103 THR A HB   1 
ATOM   915  H  HG1  . THR A 1 103 ? 22.93000 30.72200  29.61100 1.000 62.38117  ? 103 THR A HG1  1 
ATOM   916  H  HG21 . THR A 1 103 ? 22.80300 28.44700  29.41700 1.000 46.60481  ? 103 THR A HG21 1 
ATOM   917  H  HG22 . THR A 1 103 ? 22.17500 27.61700  30.60400 1.000 46.60481  ? 103 THR A HG22 1 
ATOM   918  H  HG23 . THR A 1 103 ? 21.23700 28.41200  29.61400 1.000 46.60481  ? 103 THR A HG23 1 
ATOM   919  N  N    . HIS A 1 104 ? 21.51700 28.27000  33.68600 1.000 33.40403  ? 104 HIS A N    1 
ATOM   920  C  CA   . HIS A 1 104 ? 21.31900 27.10600  34.54400 1.000 37.65138  ? 104 HIS A CA   1 
ATOM   921  C  C    . HIS A 1 104 ? 19.96200 27.15500  35.23600 1.000 33.11492  ? 104 HIS A C    1 
ATOM   922  O  O    . HIS A 1 104 ? 19.28100 26.12900  35.35900 1.000 29.54787  ? 104 HIS A O    1 
ATOM   923  C  CB   . HIS A 1 104 ? 22.43200 27.02600  35.58900 1.000 41.72782  ? 104 HIS A CB   1 
ATOM   924  C  CG   . HIS A 1 104 ? 23.73200 26.50900  35.05800 1.000 53.89920  ? 104 HIS A CG   1 
ATOM   925  N  ND1  . HIS A 1 104 ? 24.92900 26.70400  35.71200 1.000 56.92820  ? 104 HIS A ND1  1 
ATOM   926  C  CD2  . HIS A 1 104 ? 24.02500 25.80300  33.94100 1.000 71.29082  ? 104 HIS A CD2  1 
ATOM   927  C  CE1  . HIS A 1 104 ? 25.90400 26.14300  35.01900 1.000 63.60629  ? 104 HIS A CE1  1 
ATOM   928  N  NE2  . HIS A 1 104 ? 25.38200 25.58900  33.94000 1.000 82.48830  ? 104 HIS A NE2  1 
ATOM   929  H  H    . HIS A 1 104 ? 22.18300 28.77000  33.90400 1.000 40.02460  ? 104 HIS A H    1 
ATOM   930  H  HA   . HIS A 1 104 ? 21.35600 26.30900  33.99300 1.000 45.12141  ? 104 HIS A HA   1 
ATOM   931  H  HB2  . HIS A 1 104 ? 22.59100 27.91600  35.94300 1.000 50.01314  ? 104 HIS A HB2  1 
ATOM   932  H  HB3  . HIS A 1 104 ? 22.14700 26.43200  36.30200 1.000 50.01314  ? 104 HIS A HB3  1 
ATOM   933  H  HD1  . HIS A 1 104 ? 25.02700 27.12500  36.45600 1.000 68.25360  ? 104 HIS A HD1  1 
ATOM   934  H  HD2  . HIS A 1 104 ? 23.42000 25.51600  33.29500 1.000 85.48875  ? 104 HIS A HD2  1 
ATOM   935  H  HE1  . HIS A 1 104 ? 26.80400 26.13800  35.25200 1.000 76.26731  ? 104 HIS A HE1  1 
ATOM   936  N  N    . ALA A 1 105 ? 19.55000 28.34000  35.69200 1.000 31.91479  ? 105 ALA A N    1 
ATOM   937  C  CA   . ALA A 1 105 ? 18.35800 28.44400  36.52500 1.000 33.32031  ? 105 ALA A CA   1 
ATOM   938  C  C    . ALA A 1 105 ? 17.08700 28.21900  35.71600 1.000 37.92024  ? 105 ALA A C    1 
ATOM   939  O  O    . ALA A 1 105 ? 16.19600 27.47400  36.14000 1.000 29.03793  ? 105 ALA A O    1 
ATOM   940  C  CB   . ALA A 1 105 ? 18.32000 29.81100  37.21100 1.000 41.16563  ? 105 ALA A CB   1 
ATOM   941  H  H    . ALA A 1 105 ? 19.94100 29.08900  35.53400 1.000 38.23751  ? 105 ALA A H    1 
ATOM   942  H  HA   . ALA A 1 105 ? 18.39900 27.75700  37.20900 1.000 39.92413  ? 105 ALA A HA   1 
ATOM   943  H  HB1  . ALA A 1 105 ? 17.55000 29.84700  37.80000 1.000 49.33851  ? 105 ALA A HB1  1 
ATOM   944  H  HB2  . ALA A 1 105 ? 19.13500 29.92900  37.72400 1.000 49.33851  ? 105 ALA A HB2  1 
ATOM   945  H  HB3  . ALA A 1 105 ? 18.25200 30.50200  36.53400 1.000 49.33851  ? 105 ALA A HB3  1 
ATOM   946  N  N    . LYS A 1 106 ? 16.97400 28.87000  34.55300 1.000 31.14852  ? 106 LYS A N    1 
ATOM   947  C  CA   . LYS A 1 106 ? 15.77400 28.70900  33.73700 1.000 34.20023  ? 106 LYS A CA   1 
ATOM   948  C  C    . LYS A 1 106 ? 15.57200 27.25400  33.34200 1.000 31.36836  ? 106 LYS A C    1 
ATOM   949  O  O    . LYS A 1 106 ? 14.44600 26.74500  33.36900 1.000 34.18394  ? 106 LYS A O    1 
ATOM   950  C  CB   . LYS A 1 106 ? 15.85400 29.58900  32.48700 1.000 39.74278  ? 106 LYS A CB   1 
ATOM   951  C  CG   . LYS A 1 106 ? 16.03000 31.07300  32.76800 1.000 46.70953  ? 106 LYS A CG   1 
ATOM   952  C  CD   . LYS A 1 106 ? 16.61900 31.81900  31.56900 1.000 71.23936  ? 106 LYS A CD   1 
ATOM   953  C  CE   . LYS A 1 106 ? 15.92800 31.45100  30.25900 1.000 66.43660  ? 106 LYS A CE   1 
ATOM   954  N  NZ   . LYS A 1 106 ? 14.44700 31.60700  30.33900 1.000 66.35350  ? 106 LYS A NZ   1 
ATOM   955  H  H    . LYS A 1 106 ? 17.56700 29.39800  34.22300 1.000 37.31798  ? 106 LYS A H    1 
ATOM   956  H  HA   . LYS A 1 106 ? 15.00800 28.99800  34.25700 1.000 40.98003  ? 106 LYS A HA   1 
ATOM   957  H  HB2  . LYS A 1 106 ? 16.61200 29.30000  31.95500 1.000 47.63110  ? 106 LYS A HB2  1 
ATOM   958  H  HB3  . LYS A 1 106 ? 15.03400 29.48200  31.98200 1.000 47.63110  ? 106 LYS A HB3  1 
ATOM   959  H  HG2  . LYS A 1 106 ? 15.16600 31.46300  32.97300 1.000 55.99120  ? 106 LYS A HG2  1 
ATOM   960  H  HG3  . LYS A 1 106 ? 16.63200 31.18600  33.52000 1.000 55.99120  ? 106 LYS A HG3  1 
ATOM   961  H  HD2  . LYS A 1 106 ? 16.51500 32.77300  31.70600 1.000 85.42700  ? 106 LYS A HD2  1 
ATOM   962  H  HD3  . LYS A 1 106 ? 17.55900 31.59600  31.48600 1.000 85.42700  ? 106 LYS A HD3  1 
ATOM   963  H  HE2  . LYS A 1 106 ? 16.25500 32.03000  29.55300 1.000 79.66368  ? 106 LYS A HE2  1 
ATOM   964  H  HE3  . LYS A 1 106 ? 16.12200 30.52500  30.04500 1.000 79.66368  ? 106 LYS A HE3  1 
ATOM   965  H  HZ1  . LYS A 1 106 ? 14.07500 31.38700  29.56200 1.000 79.56396  ? 106 LYS A HZ1  1 
ATOM   966  H  HZ2  . LYS A 1 106 ? 14.12000 31.07900  30.97600 1.000 79.56396  ? 106 LYS A HZ2  1 
ATOM   967  H  HZ3  . LYS A 1 106 ? 14.24000 32.45200  30.53000 1.000 79.56396  ? 106 LYS A HZ3  1 
ATOM   968  N  N    . ARG A 1 107 ? 16.65300 26.56600  32.97100 1.000 33.47733  ? 107 ARG A N    1 
ATOM   969  C  CA   . ARG A 1 107 ? 16.54300 25.16700  32.57400 1.000 35.85483  ? 107 ARG A CA   1 
ATOM   970  C  C    . ARG A 1 107 ? 16.17600 24.28500  33.76200 1.000 33.80983  ? 107 ARG A C    1 
ATOM   971  O  O    . ARG A 1 107 ? 15.29200 23.42700  33.66300 1.000 27.71336  ? 107 ARG A O    1 
ATOM   972  C  CB   . ARG A 1 107 ? 17.85400 24.70400  31.93800 1.000 41.40319  ? 107 ARG A CB   1 
ATOM   973  C  CG   . ARG A 1 107 ? 17.92100 23.20800  31.66400 1.000 47.00896  ? 107 ARG A CG   1 
ATOM   974  C  CD   . ARG A 1 107 ? 18.85100 22.88500  30.50300 1.000 50.50458  ? 107 ARG A CD   1 
ATOM   975  N  NE   . ARG A 1 107 ? 18.24400 21.94100  29.57200 1.000 66.83213  ? 107 ARG A NE   1 
ATOM   976  C  CZ   . ARG A 1 107 ? 17.67700 22.27000  28.41700 1.000 57.85918  ? 107 ARG A CZ   1 
ATOM   977  N  NH1  . ARG A 1 107 ? 17.59700 23.52900  28.01700 1.000 63.83748  ? 107 ARG A NH1  1 
ATOM   978  N  NH2  . ARG A 1 107 ? 17.17300 21.31000  27.64700 1.000 55.85055  ? 107 ARG A NH2  1 
ATOM   979  H  H    . ARG A 1 107 ? 17.45200 26.88400  32.94100 1.000 40.11255  ? 107 ARG A H    1 
ATOM   980  H  HA   . ARG A 1 107 ? 15.83900 25.08100  31.91200 1.000 42.96556  ? 107 ARG A HA   1 
ATOM   981  H  HB2  . ARG A 1 107 ? 17.96800 25.16400  31.09200 1.000 49.62359  ? 107 ARG A HB2  1 
ATOM   982  H  HB3  . ARG A 1 107 ? 18.58400 24.92600  32.53700 1.000 49.62359  ? 107 ARG A HB3  1 
ATOM   983  H  HG2  . ARG A 1 107 ? 18.25300 22.75300  32.45300 1.000 56.35051  ? 107 ARG A HG2  1 
ATOM   984  H  HG3  . ARG A 1 107 ? 17.03500 22.88400  31.44100 1.000 56.35051  ? 107 ARG A HG3  1 
ATOM   985  H  HD2  . ARG A 1 107 ? 19.05600 23.70000  30.02000 1.000 60.54526  ? 107 ARG A HD2  1 
ATOM   986  H  HD3  . ARG A 1 107 ? 19.66800 22.48900  30.84800 1.000 60.54526  ? 107 ARG A HD3  1 
ATOM   987  H  HE   . ARG A 1 107 ? 18.25400 21.10800  29.78700 1.000 80.13832  ? 107 ARG A HE   1 
ATOM   988  H  HH11 . ARG A 1 107 ? 17.91700 24.15800  28.50800 1.000 76.54473  ? 107 ARG A HH11 1 
ATOM   989  H  HH12 . ARG A 1 107 ? 17.22500 23.71800  27.26500 1.000 76.54473  ? 107 ARG A HH12 1 
ATOM   990  H  HH21 . ARG A 1 107 ? 17.21700 20.48900  27.90000 1.000 66.96042  ? 107 ARG A HH21 1 
ATOM   991  H  HH22 . ARG A 1 107 ? 16.80300 21.51000  26.89700 1.000 66.96042  ? 107 ARG A HH22 1 
ATOM   992  N  N    . ALA A 1 108 ? 16.84100 24.48500  34.90200 1.000 31.88925  ? 108 ALA A N    1 
ATOM   993  C  CA   . ALA A 1 108 ? 16.53300 23.68100  36.07800 1.000 31.65839  ? 108 ALA A CA   1 
ATOM   994  C  C    . ALA A 1 108 ? 15.07300 23.84700  36.48500 1.000 36.67990  ? 108 ALA A C    1 
ATOM   995  O  O    . ALA A 1 108 ? 14.34500 22.85900  36.64800 1.000 27.78077  ? 108 ALA A O    1 
ATOM   996  C  CB   . ALA A 1 108 ? 17.46700 24.05900  37.22800 1.000 30.39729  ? 108 ALA A CB   1 
ATOM   997  H  H    . ALA A 1 108 ? 17.46200 25.06900  35.01600 1.000 38.20686  ? 108 ALA A H    1 
ATOM   998  H  HA   . ALA A 1 108 ? 16.68200 22.74500  35.86900 1.000 37.92983  ? 108 ALA A HA   1 
ATOM   999  H  HB1  . ALA A 1 108 ? 17.26600 23.50100  37.99500 1.000 36.41651  ? 108 ALA A HB1  1 
ATOM   1000 H  HB2  . ALA A 1 108 ? 18.38500 23.91900  36.94800 1.000 36.41651  ? 108 ALA A HB2  1 
ATOM   1001 H  HB3  . ALA A 1 108 ? 17.32900 24.99300  37.45200 1.000 36.41651  ? 108 ALA A HB3  1 
ATOM   1002 N  N    . TYR A 1 109 ? 14.62600 25.09500  36.64700 1.000 25.71797  ? 109 TYR A N    1 
ATOM   1003 C  CA   . TYR A 1 109 ? 13.24100 25.34900  37.03400 1.000 28.38548  ? 109 TYR A CA   1 
ATOM   1004 C  C    . TYR A 1 109 ? 12.27600 24.77000  36.01200 1.000 30.44522  ? 109 TYR A C    1 
ATOM   1005 O  O    . TYR A 1 109 ? 11.32500 24.06100  36.35900 1.000 30.60571  ? 109 TYR A O    1 
ATOM   1006 C  CB   . TYR A 1 109 ? 13.00600 26.85300  37.18000 1.000 35.00180  ? 109 TYR A CB   1 
ATOM   1007 C  CG   . TYR A 1 109 ? 11.61000 27.20700  37.64100 1.000 32.67362  ? 109 TYR A CG   1 
ATOM   1008 C  CD1  . TYR A 1 109 ? 11.17400 26.86400  38.91300 1.000 42.19259  ? 109 TYR A CD1  1 
ATOM   1009 C  CD2  . TYR A 1 109 ? 10.72300 27.86600  36.79900 1.000 41.53827  ? 109 TYR A CD2  1 
ATOM   1010 C  CE1  . TYR A 1 109 ? 9.90000  27.18100  39.34200 1.000 49.51247  ? 109 TYR A CE1  1 
ATOM   1011 C  CE2  . TYR A 1 109 ? 9.44300  28.18600  37.21800 1.000 48.21668  ? 109 TYR A CE2  1 
ATOM   1012 C  CZ   . TYR A 1 109 ? 9.03800  27.84000  38.49100 1.000 50.60144  ? 109 TYR A CZ   1 
ATOM   1013 O  OH   . TYR A 1 109 ? 7.76700  28.15200  38.92000 1.000 64.06004  ? 109 TYR A OH   1 
ATOM   1014 H  H    . TYR A 1 109 ? 15.10100 25.80400  36.53900 1.000 30.80132  ? 109 TYR A H    1 
ATOM   1015 H  HA   . TYR A 1 109 ? 13.07700 24.92600  37.89100 1.000 34.00233  ? 109 TYR A HA   1 
ATOM   1016 H  HB2  . TYR A 1 109 ? 13.63200 27.20500  37.83300 1.000 41.94192  ? 109 TYR A HB2  1 
ATOM   1017 H  HB3  . TYR A 1 109 ? 13.15100 27.27600  36.32000 1.000 41.94192  ? 109 TYR A HB3  1 
ATOM   1018 H  HD1  . TYR A 1 109 ? 11.75000 26.41300  39.48700 1.000 50.57087  ? 109 TYR A HD1  1 
ATOM   1019 H  HD2  . TYR A 1 109 ? 10.99300 28.09600  35.93900 1.000 49.78568  ? 109 TYR A HD2  1 
ATOM   1020 H  HE1  . TYR A 1 109 ? 9.62500  26.95100  40.20000 1.000 59.35472  ? 109 TYR A HE1  1 
ATOM   1021 H  HE2  . TYR A 1 109 ? 8.86000  28.63000  36.64500 1.000 57.79978  ? 109 TYR A HE2  1 
ATOM   1022 H  HH   . TYR A 1 109 ? 7.34200  28.53600  38.30400 1.000 76.81180  ? 109 TYR A HH   1 
ATOM   1023 N  N    . ARG A 1 110 ? 12.50600 25.08400  34.73800 1.000 30.61424  ? 110 ARG A N    1 
ATOM   1024 C  CA   . ARG A 1 110 ? 11.63700 24.62800  33.66000 1.000 38.61915  ? 110 ARG A CA   1 
ATOM   1025 C  C    . ARG A 1 110 ? 11.47500 23.11200  33.66700 1.000 36.94584  ? 110 ARG A C    1 
ATOM   1026 O  O    . ARG A 1 110 ? 10.35600 22.59300  33.57700 1.000 31.09659  ? 110 ARG A O    1 
ATOM   1027 C  CB   . ARG A 1 110 ? 12.22800 25.11100  32.33600 1.000 39.24296  ? 110 ARG A CB   1 
ATOM   1028 C  CG   . ARG A 1 110 ? 11.48100 24.71400  31.09600 1.000 45.68297  ? 110 ARG A CG   1 
ATOM   1029 C  CD   . ARG A 1 110 ? 11.73500 25.73900  30.00400 1.000 52.39656  ? 110 ARG A CD   1 
ATOM   1030 N  NE   . ARG A 1 110 ? 10.85400 25.54500  28.86100 1.000 51.95198  ? 110 ARG A NE   1 
ATOM   1031 C  CZ   . ARG A 1 110 ? 11.04900 24.63100  27.92300 1.000 49.07856  ? 110 ARG A CZ   1 
ATOM   1032 N  NH1  . ARG A 1 110 ? 12.09500 23.82100  27.95600 1.000 40.39604  ? 110 ARG A NH1  1 
ATOM   1033 N  NH2  . ARG A 1 110 ? 10.17400 24.52800  26.92700 1.000 60.76817  ? 110 ARG A NH2  1 
ATOM   1034 H  H    . ARG A 1 110 ? 13.16700 25.56400  34.46900 1.000 36.67685  ? 110 ARG A H    1 
ATOM   1035 H  HA   . ARG A 1 110 ? 10.75100 25.00500  33.77200 1.000 46.28275  ? 110 ARG A HA   1 
ATOM   1036 H  HB2  . ARG A 1 110 ? 12.26000 26.08000  32.35400 1.000 47.03131  ? 110 ARG A HB2  1 
ATOM   1037 H  HB3  . ARG A 1 110 ? 13.12600 24.75100  32.25600 1.000 47.03131  ? 110 ARG A HB3  1 
ATOM   1038 H  HG2  . ARG A 1 110 ? 11.78700 23.84700  30.79000 1.000 54.75932  ? 110 ARG A HG2  1 
ATOM   1039 H  HG3  . ARG A 1 110 ? 10.52900 24.68300  31.28200 1.000 54.75932  ? 110 ARG A HG3  1 
ATOM   1040 H  HD2  . ARG A 1 110 ? 11.58000 26.62900  30.35800 1.000 62.81564  ? 110 ARG A HD2  1 
ATOM   1041 H  HD3  . ARG A 1 110 ? 12.65100 25.65800  29.69700 1.000 62.81564  ? 110 ARG A HD3  1 
ATOM   1042 H  HE   . ARG A 1 110 ? 10.16600 26.05600  28.79100 1.000 62.28213  ? 110 ARG A HE   1 
ATOM   1043 H  HH11 . ARG A 1 110 ? 12.66600 23.88200  28.59600 1.000 48.41501  ? 110 ARG A HH11 1 
ATOM   1044 H  HH12 . ARG A 1 110 ? 12.20300 23.23300  27.33700 1.000 48.41501  ? 110 ARG A HH12 1 
ATOM   1045 H  HH21 . ARG A 1 110 ? 9.49200  25.05100  26.89700 1.000 72.86157  ? 110 ARG A HH21 1 
ATOM   1046 H  HH22 . ARG A 1 110 ? 10.29100 23.93700  26.31300 1.000 72.86157  ? 110 ARG A HH22 1 
ATOM   1047 N  N    . GLU A 1 111 ? 12.58100 22.38300  33.77300 1.000 28.08464  ? 111 GLU A N    1 
ATOM   1048 C  CA   . GLU A 1 111 ? 12.50500 20.93100  33.66700 1.000 29.46558  ? 111 GLU A CA   1 
ATOM   1049 C  C    . GLU A 1 111 ? 11.94900 20.30300  34.93400 1.000 32.57862  ? 111 GLU A C    1 
ATOM   1050 O  O    . GLU A 1 111 ? 11.35000 19.22500  34.87400 1.000 30.04823  ? 111 GLU A O    1 
ATOM   1051 C  CB   . GLU A 1 111 ? 13.88400 20.37300  33.32100 1.000 36.43525  ? 111 GLU A CB   1 
ATOM   1052 C  CG   . GLU A 1 111 ? 14.40500 20.92900  31.99200 1.000 42.23800  ? 111 GLU A CG   1 
ATOM   1053 C  CD   . GLU A 1 111 ? 15.33900 19.98800  31.26200 1.000 43.23298  ? 111 GLU A CD   1 
ATOM   1054 O  OE1  . GLU A 1 111 ? 16.13800 19.29800  31.92600 1.000 42.51821  ? 111 GLU A OE1  1 
ATOM   1055 O  OE2  . GLU A 1 111 ? 15.27500 19.95300  30.01400 1.000 43.44588  ? 111 GLU A OE2  1 
ATOM   1056 H  H    . GLU A 1 111 ? 13.37100 22.69700  33.90300 1.000 33.64133  ? 111 GLU A H    1 
ATOM   1057 H  HA   . GLU A 1 111 ? 11.90600 20.68300  32.94600 1.000 35.29846  ? 111 GLU A HA   1 
ATOM   1058 H  HB2  . GLU A 1 111 ? 14.51200 20.61500  34.01900 1.000 43.66207  ? 111 GLU A HB2  1 
ATOM   1059 H  HB3  . GLU A 1 111 ? 13.82800 19.40700  33.24600 1.000 43.66207  ? 111 GLU A HB3  1 
ATOM   1060 H  HG2  . GLU A 1 111 ? 13.65000 21.10600  31.41000 1.000 50.62536  ? 111 GLU A HG2  1 
ATOM   1061 H  HG3  . GLU A 1 111 ? 14.89000 21.75100  32.16600 1.000 50.62536  ? 111 GLU A HG3  1 
ATOM   1062 N  N    . LEU A 1 112 ? 12.11500 20.96600  36.08000 1.000 30.03022  ? 112 LEU A N    1 
ATOM   1063 C  CA   . LEU A 1 112 ? 11.45700 20.50900  37.29900 1.000 35.80575  ? 112 LEU A CA   1 
ATOM   1064 C  C    . LEU A 1 112 ? 9.95200  20.73800  37.21800 1.000 35.95281  ? 112 LEU A C    1 
ATOM   1065 O  O    . LEU A 1 112 ? 9.16500  19.92000  37.70800 1.000 36.76164  ? 112 LEU A O    1 
ATOM   1066 C  CB   . LEU A 1 112 ? 12.06000 21.23000  38.50600 1.000 34.75644  ? 112 LEU A CB   1 
ATOM   1067 C  CG   . LEU A 1 112 ? 12.30600 20.47500  39.81000 1.000 42.71126  ? 112 LEU A CG   1 
ATOM   1068 C  CD1  . LEU A 1 112 ? 13.03000 19.16000  39.59900 1.000 38.91504  ? 112 LEU A CD1  1 
ATOM   1069 C  CD2  . LEU A 1 112 ? 13.11300 21.37600  40.73900 1.000 46.77592  ? 112 LEU A CD2  1 
ATOM   1070 H  H    . LEU A 1 112 ? 12.59500 21.67300  36.17600 1.000 35.97602  ? 112 LEU A H    1 
ATOM   1071 H  HA   . LEU A 1 112 ? 11.60700 19.55700  37.41500 1.000 42.90666  ? 112 LEU A HA   1 
ATOM   1072 H  HB2  . LEU A 1 112 ? 12.92300 21.57700  38.22900 1.000 41.64749  ? 112 LEU A HB2  1 
ATOM   1073 H  HB3  . LEU A 1 112 ? 11.46400 21.96200  38.72800 1.000 41.64749  ? 112 LEU A HB3  1 
ATOM   1074 H  HG   . LEU A 1 112 ? 11.45100 20.24900  40.20800 1.000 51.19327  ? 112 LEU A HG   1 
ATOM   1075 H  HD11 . LEU A 1 112 ? 13.30700 18.81000  40.46000 1.000 46.63781  ? 112 LEU A HD11 1 
ATOM   1076 H  HD12 . LEU A 1 112 ? 12.42900 18.53400  39.16500 1.000 46.63781  ? 112 LEU A HD12 1 
ATOM   1077 H  HD13 . LEU A 1 112 ? 13.80700 19.31400  39.03900 1.000 46.63781  ? 112 LEU A HD13 1 
ATOM   1078 H  HD21 . LEU A 1 112 ? 13.21400 20.93500  41.59700 1.000 56.07086  ? 112 LEU A HD21 1 
ATOM   1079 H  HD22 . LEU A 1 112 ? 13.98400 21.53600  40.34600 1.000 56.07086  ? 112 LEU A HD22 1 
ATOM   1080 H  HD23 . LEU A 1 112 ? 12.64100 22.21600  40.85300 1.000 56.07086  ? 112 LEU A HD23 1 
ATOM   1081 N  N    . VAL A 1 113 ? 9.53400  21.83500  36.58300 1.000 32.60018  ? 113 VAL A N    1 
ATOM   1082 C  CA   . VAL A 1 113 ? 8.11200  22.12300  36.42700 1.000 36.40489  ? 113 VAL A CA   1 
ATOM   1083 C  C    . VAL A 1 113 ? 7.49300  21.23400  35.35600 1.000 42.05109  ? 113 VAL A C    1 
ATOM   1084 O  O    . VAL A 1 113 ? 6.40200  20.68400  35.54300 1.000 45.47671  ? 113 VAL A O    1 
ATOM   1085 C  CB   . VAL A 1 113 ? 7.91300  23.61600  36.09900 1.000 41.12486  ? 113 VAL A CB   1 
ATOM   1086 C  CG1  . VAL A 1 113 ? 6.53000  23.85800  35.50200 1.000 43.26842  ? 113 VAL A CG1  1 
ATOM   1087 C  CG2  . VAL A 1 113 ? 8.12200  24.47400  37.33700 1.000 41.83935  ? 113 VAL A CG2  1 
ATOM   1088 H  H    . VAL A 1 113 ? 10.05300 22.42500  36.23400 1.000 39.05998  ? 113 VAL A H    1 
ATOM   1089 H  HA   . VAL A 1 113 ? 7.66600  21.93300  37.26700 1.000 43.62563  ? 113 VAL A HA   1 
ATOM   1090 H  HB   . VAL A 1 113 ? 8.57400  23.87800  35.43900 1.000 49.28960  ? 113 VAL A HB   1 
ATOM   1091 H  HG11 . VAL A 1 113 ? 6.31200  24.80000  35.58100 1.000 51.86186  ? 113 VAL A HG11 1 
ATOM   1092 H  HG12 . VAL A 1 113 ? 6.53900  23.59700  34.56800 1.000 51.86186  ? 113 VAL A HG12 1 
ATOM   1093 H  HG13 . VAL A 1 113 ? 5.88000  23.32600  35.98800 1.000 51.86186  ? 113 VAL A HG13 1 
ATOM   1094 H  HG21 . VAL A 1 113 ? 7.94200  25.40100  37.11300 1.000 50.14698  ? 113 VAL A HG21 1 
ATOM   1095 H  HG22 . VAL A 1 113 ? 7.51400  24.17800  38.03200 1.000 50.14698  ? 113 VAL A HG22 1 
ATOM   1096 H  HG23 . VAL A 1 113 ? 9.03900  24.37800  37.63700 1.000 50.14698  ? 113 VAL A HG23 1 
ATOM   1097 N  N    . LEU A 1 114 ? 8.17600  21.07800  34.22100 1.000 41.78063  ? 114 LEU A N    1 
ATOM   1098 C  CA   . LEU A 1 114 ? 7.58000  20.38400  33.08600 1.000 42.25931  ? 114 LEU A CA   1 
ATOM   1099 C  C    . LEU A 1 114 ? 7.45200  18.88900  33.33600 1.000 41.99053  ? 114 LEU A C    1 
ATOM   1100 O  O    . LEU A 1 114 ? 6.58300  18.23900  32.74400 1.000 39.97924  ? 114 LEU A O    1 
ATOM   1101 C  CB   . LEU A 1 114 ? 8.41000  20.63200  31.82800 1.000 34.19326  ? 114 LEU A CB   1 
ATOM   1102 C  CG   . LEU A 1 114 ? 8.27500  22.00300  31.16400 1.000 32.72879  ? 114 LEU A CG   1 
ATOM   1103 C  CD1  . LEU A 1 114 ? 9.12000  22.06000  29.90100 1.000 42.03771  ? 114 LEU A CD1  1 
ATOM   1104 C  CD2  . LEU A 1 114 ? 6.82200  22.32500  30.84100 1.000 46.54958  ? 114 LEU A CD2  1 
ATOM   1105 H  H    . LEU A 1 114 ? 8.97600  21.36300  34.08500 1.000 50.07651  ? 114 LEU A H    1 
ATOM   1106 H  HA   . LEU A 1 114 ? 6.68900  20.74000  32.94300 1.000 50.65093  ? 114 LEU A HA   1 
ATOM   1107 H  HB2  . LEU A 1 114 ? 9.34500  20.52200  32.06100 1.000 40.97167  ? 114 LEU A HB2  1 
ATOM   1108 H  HB3  . LEU A 1 114 ? 8.15300  19.97200  31.16600 1.000 40.97167  ? 114 LEU A HB3  1 
ATOM   1109 H  HG   . LEU A 1 114 ? 8.59200  22.67800  31.78400 1.000 39.21431  ? 114 LEU A HG   1 
ATOM   1110 H  HD11 . LEU A 1 114 ? 9.02500  22.93600  29.49600 1.000 50.38502  ? 114 LEU A HD11 1 
ATOM   1111 H  HD12 . LEU A 1 114 ? 10.04900 21.90300  30.13500 1.000 50.38502  ? 114 LEU A HD12 1 
ATOM   1112 H  HD13 . LEU A 1 114 ? 8.81400  21.37600  29.28500 1.000 50.38502  ? 114 LEU A HD13 1 
ATOM   1113 H  HD21 . LEU A 1 114 ? 6.78300  23.17100  30.36800 1.000 55.79926  ? 114 LEU A HD21 1 
ATOM   1114 H  HD22 . LEU A 1 114 ? 6.45800  21.61800  30.28500 1.000 55.79926  ? 114 LEU A HD22 1 
ATOM   1115 H  HD23 . LEU A 1 114 ? 6.32000  22.38600  31.66900 1.000 55.79926  ? 114 LEU A HD23 1 
ATOM   1116 N  N    . MET A 1 115 ? 8.29600  18.32200  34.19800 1.000 39.88133  ? 115 MET A N    1 
ATOM   1117 C  CA   . MET A 1 115 ? 8.25800  16.88100  34.39000 1.000 47.53373  ? 115 MET A CA   1 
ATOM   1118 C  C    . MET A 1 115 ? 7.00500  16.44400  35.13300 1.000 51.29384  ? 115 MET A C    1 
ATOM   1119 O  O    . MET A 1 115 ? 6.61800  15.27500  35.04000 1.000 46.05732  ? 115 MET A O    1 
ATOM   1120 C  CB   . MET A 1 115 ? 9.51600  16.41100  35.12100 1.000 48.39807  ? 115 MET A CB   1 
ATOM   1121 C  CG   . MET A 1 115 ? 10.18700 15.24900  34.40000 1.000 34.20342  ? 115 MET A CG   1 
ATOM   1122 S  SD   . MET A 1 115 ? 11.84200 14.79600  34.94300 1.000 62.56064  ? 115 MET A SD   1 
ATOM   1123 C  CE   . MET A 1 115 ? 12.67300 16.35700  35.18300 1.000 45.06398  ? 115 MET A CE   1 
ATOM   1124 H  H    . MET A 1 115 ? 8.88100  18.74000  34.66900 1.000 47.79736  ? 115 MET A H    1 
ATOM   1125 H  HA   . MET A 1 115 ? 8.26200  16.44700  33.52200 1.000 56.98024  ? 115 MET A HA   1 
ATOM   1126 H  HB2  . MET A 1 115 ? 10.14900 17.14500  35.17100 1.000 58.01745  ? 115 MET A HB2  1 
ATOM   1127 H  HB3  . MET A 1 115 ? 9.27700  16.11900  36.01400 1.000 58.01745  ? 115 MET A HB3  1 
ATOM   1128 H  HG2  . MET A 1 115 ? 9.62800  14.46400  34.51300 1.000 40.98386  ? 115 MET A HG2  1 
ATOM   1129 H  HG3  . MET A 1 115 ? 10.25100 15.47700  33.45900 1.000 40.98386  ? 115 MET A HG3  1 
ATOM   1130 H  HE1  . MET A 1 115 ? 13.58100 16.18800  35.48000 1.000 54.01654  ? 115 MET A HE1  1 
ATOM   1131 H  HE2  . MET A 1 115 ? 12.68400 16.84200  34.34300 1.000 54.01654  ? 115 MET A HE2  1 
ATOM   1132 H  HE3  . MET A 1 115 ? 12.19600 16.86900  35.85500 1.000 54.01654  ? 115 MET A HE3  1 
ATOM   1133 N  N    . LYS A 1 116 ? 6.35600  17.35900  35.85500 1.000 49.46215  ? 116 LYS A N    1 
ATOM   1134 C  CA   . LYS A 1 116 ? 5.05200  17.08600  36.44300 1.000 55.05434  ? 116 LYS A CA   1 
ATOM   1135 C  C    . LYS A 1 116 ? 3.91200  17.25400  35.44600 1.000 42.71488  ? 116 LYS A C    1 
ATOM   1136 O  O    . LYS A 1 116 ? 2.78500  16.84600  35.74300 1.000 54.65937  ? 116 LYS A O    1 
ATOM   1137 C  CB   . LYS A 1 116 ? 4.81800  18.00300  37.64800 1.000 41.51983  ? 116 LYS A CB   1 
ATOM   1138 H  H    . LYS A 1 116 ? 6.65400  18.14900  36.01700 1.000 59.29435  ? 116 LYS A H    1 
ATOM   1139 H  HA   . LYS A 1 116 ? 5.03900  16.16900  36.76100 1.000 66.00497  ? 116 LYS A HA   1 
ATOM   1140 N  N    . CYS A 1 117 ? 4.17600  17.83800  34.27600 1.000 44.07839  ? 117 CYS A N    1 
ATOM   1141 C  CA   . CYS A 1 117 ? 3.14000  18.03500  33.27100 1.000 48.06206  ? 117 CYS A CA   1 
ATOM   1142 C  C    . CYS A 1 117 ? 2.99200  16.84700  32.32900 1.000 59.48114  ? 117 CYS A C    1 
ATOM   1143 O  O    . CYS A 1 117 ? 1.89900  16.62800  31.79200 1.000 70.52383  ? 117 CYS A O    1 
ATOM   1144 C  CB   . CYS A 1 117 ? 3.43700  19.28900  32.44200 1.000 51.61907  ? 117 CYS A CB   1 
ATOM   1145 S  SG   . CYS A 1 117 ? 3.47000  20.82600  33.38600 1.000 58.83384  ? 117 CYS A SG   1 
ATOM   1146 H  H    . CYS A 1 117 ? 4.95000  18.12900  34.04300 1.000 52.83383  ? 117 CYS A H    1 
ATOM   1147 H  HA   . CYS A 1 117 ? 2.29500  18.16400  33.72800 1.000 57.61423  ? 117 CYS A HA   1 
ATOM   1148 H  HB2  . CYS A 1 117 ? 4.30600  19.18300  32.02400 1.000 61.88265  ? 117 CYS A HB2  1 
ATOM   1149 H  HB3  . CYS A 1 117 ? 2.75100  19.37800  31.76200 1.000 61.88265  ? 117 CYS A HB3  1 
ATOM   1150 H  HG   . CYS A 1 117 ? 4.42500  20.81800  34.11400 1.000 70.54037  ? 117 CYS A HG   1 
ATOM   1151 N  N    . VAL A 1 118 ? 4.05600  16.07600  32.11200 1.000 46.73531  ? 118 VAL A N    1 
ATOM   1152 C  CA   . VAL A 1 118 ? 4.03800  14.97500  31.15800 1.000 40.34231  ? 118 VAL A CA   1 
ATOM   1153 C  C    . VAL A 1 118 ? 3.97200  13.64800  31.90800 1.000 37.98401  ? 118 VAL A C    1 
ATOM   1154 O  O    . VAL A 1 118 ? 4.40200  13.53300  33.05900 1.000 36.57399  ? 118 VAL A O    1 
ATOM   1155 C  CB   . VAL A 1 118 ? 5.26900  15.01700  30.22700 1.000 39.60473  ? 118 VAL A CB   1 
ATOM   1156 C  CG1  . VAL A 1 118 ? 5.37200  16.37700  29.55000 1.000 41.67407  ? 118 VAL A CG1  1 
ATOM   1157 C  CG2  . VAL A 1 118 ? 6.54000  14.70000  31.00400 1.000 34.90090  ? 118 VAL A CG2  1 
ATOM   1158 H  H    . VAL A 1 118 ? 4.81000  16.17500  32.51200 1.000 56.02213  ? 118 VAL A H    1 
ATOM   1159 H  HA   . VAL A 1 118 ? 3.23600  15.04300  30.61700 1.000 48.35054  ? 118 VAL A HA   1 
ATOM   1160 H  HB   . VAL A 1 118 ? 5.16600  14.34300  29.53700 1.000 47.46544  ? 118 VAL A HB   1 
ATOM   1161 H  HG11 . VAL A 1 118 ? 5.98300  16.31100  28.80000 1.000 49.94864  ? 118 VAL A HG11 1 
ATOM   1162 H  HG12 . VAL A 1 118 ? 4.49200  16.64100  29.23700 1.000 49.94864  ? 118 VAL A HG12 1 
ATOM   1163 H  HG13 . VAL A 1 118 ? 5.70300  17.02500  30.19100 1.000 49.94864  ? 118 VAL A HG13 1 
ATOM   1164 H  HG21 . VAL A 1 118 ? 7.30800  14.96100  30.47200 1.000 41.82085  ? 118 VAL A HG21 1 
ATOM   1165 H  HG22 . VAL A 1 118 ? 6.53200  15.19400  31.83800 1.000 41.82085  ? 118 VAL A HG22 1 
ATOM   1166 H  HG23 . VAL A 1 118 ? 6.57100  13.74700  31.18400 1.000 41.82085  ? 118 VAL A HG23 1 
ATOM   1167 N  N    . ASN A 1 119 ? 3.42400  12.63900  31.23100 1.000 39.93056  ? 119 ASN A N    1 
ATOM   1168 C  CA   . ASN A 1 119 ? 3.30000  11.30000  31.81300 1.000 37.22687  ? 119 ASN A CA   1 
ATOM   1169 C  C    . ASN A 1 119 ? 3.23400  10.31600  30.63900 1.000 37.32597  ? 119 ASN A C    1 
ATOM   1170 O  O    . ASN A 1 119 ? 2.15800  10.05200  30.10000 1.000 36.37920  ? 119 ASN A O    1 
ATOM   1171 C  CB   . ASN A 1 119 ? 2.08300  11.19200  32.70800 1.000 39.31373  ? 119 ASN A CB   1 
ATOM   1172 C  CG   . ASN A 1 119 ? 1.95400  9.83100   33.35600 1.000 52.23705  ? 119 ASN A CG   1 
ATOM   1173 O  OD1  . ASN A 1 119 ? 2.91500  9.30400   33.92000 1.000 50.95266  ? 119 ASN A OD1  1 
ATOM   1174 N  ND2  . ASN A 1 119 ? 0.75800  9.25400   33.28800 1.000 55.29466  ? 119 ASN A ND2  1 
ATOM   1175 H  H    . ASN A 1 119 ? 3.11500  12.70300  30.43100 1.000 47.85644  ? 119 ASN A H    1 
ATOM   1176 H  HA   . ASN A 1 119 ? 4.08500  11.09400  32.34500 1.000 44.61201  ? 119 ASN A HA   1 
ATOM   1177 H  HB2  . ASN A 1 119 ? 2.14800  11.85500  33.41300 1.000 47.11623  ? 119 ASN A HB2  1 
ATOM   1178 H  HB3  . ASN A 1 119 ? 1.28600  11.34900  32.17800 1.000 47.11623  ? 119 ASN A HB3  1 
ATOM   1179 H  HD21 . ASN A 1 119 ? 0.10900  9.65600   32.89100 1.000 66.29336  ? 119 ASN A HD21 1 
ATOM   1180 H  HD22 . ASN A 1 119 ? 0.63300  8.48000   33.64100 1.000 66.29336  ? 119 ASN A HD22 1 
ATOM   1181 N  N    . HIS A 1 120 ? 4.39400  9.79000   30.25600 1.000 35.03401  ? 120 HIS A N    1 
ATOM   1182 C  CA   . HIS A 1 120 ? 4.49600  8.95100   29.07000 1.000 35.78145  ? 120 HIS A CA   1 
ATOM   1183 C  C    . HIS A 1 120 ? 5.76600  8.12100   29.16400 1.000 33.86998  ? 120 HIS A C    1 
ATOM   1184 O  O    . HIS A 1 120 ? 6.79500  8.60900   29.63400 1.000 32.21479  ? 120 HIS A O    1 
ATOM   1185 C  CB   . HIS A 1 120 ? 4.50000  9.80700   27.79800 1.000 36.51860  ? 120 HIS A CB   1 
ATOM   1186 C  CG   . HIS A 1 120 ? 4.27600  9.02400   26.54400 1.000 36.44580  ? 120 HIS A CG   1 
ATOM   1187 N  ND1  . HIS A 1 120 ? 5.28300  8.32600   25.91500 1.000 30.87076  ? 120 HIS A ND1  1 
ATOM   1188 C  CD2  . HIS A 1 120 ? 3.16000  8.82500   25.80400 1.000 39.87820  ? 120 HIS A CD2  1 
ATOM   1189 C  CE1  . HIS A 1 120 ? 4.79700  7.72900   24.84000 1.000 31.79206  ? 120 HIS A CE1  1 
ATOM   1190 N  NE2  . HIS A 1 120 ? 3.51100  8.01700   24.75000 1.000 40.79138  ? 120 HIS A NE2  1 
ATOM   1191 H  H    . HIS A 1 120 ? 5.13900  9.90600   30.67000 1.000 41.98057  ? 120 HIS A H    1 
ATOM   1192 H  HA   . HIS A 1 120 ? 3.74300  8.34100   29.02700 1.000 42.87751  ? 120 HIS A HA   1 
ATOM   1193 H  HB2  . HIS A 1 120 ? 3.79300  10.46800  27.86500 1.000 43.76208  ? 120 HIS A HB2  1 
ATOM   1194 H  HB3  . HIS A 1 120 ? 5.36000  10.24900  27.72200 1.000 43.76208  ? 120 HIS A HB3  1 
ATOM   1195 H  HD2  . HIS A 1 120 ? 2.31400  9.17100   25.97600 1.000 47.79360  ? 120 HIS A HD2  1 
ATOM   1196 H  HE1  . HIS A 1 120 ? 5.27800  7.19800   24.24800 1.000 38.09023  ? 120 HIS A HE1  1 
ATOM   1197 H  HE2  . HIS A 1 120 ? 2.98000  7.74200   24.13300 1.000 48.88942  ? 120 HIS A HE2  1 
ATOM   1198 N  N    . LYS A 1 121 ? 5.69100  6.86800   28.70100 1.000 29.19445  ? 121 LYS A N    1 
ATOM   1199 C  CA   . LYS A 1 121 ? 6.78800  5.93400   28.92600 1.000 28.54615  ? 121 LYS A CA   1 
ATOM   1200 C  C    . LYS A 1 121 ? 8.03100  6.26900   28.11600 1.000 25.88302  ? 121 LYS A C    1 
ATOM   1201 O  O    . LYS A 1 121 ? 9.11900  5.79000   28.45000 1.000 30.52296  ? 121 LYS A O    1 
ATOM   1202 C  CB   . LYS A 1 121 ? 6.35600  4.50000   28.60900 1.000 32.83805  ? 121 LYS A CB   1 
ATOM   1203 C  CG   . LYS A 1 121 ? 5.69500  4.30400   27.25500 1.000 43.43179  ? 121 LYS A CG   1 
ATOM   1204 C  CD   . LYS A 1 121 ? 5.37600  2.83100   27.04700 1.000 52.00757  ? 121 LYS A CD   1 
ATOM   1205 C  CE   . LYS A 1 121 ? 5.02500  2.51600   25.60600 1.000 56.07470  ? 121 LYS A CE   1 
ATOM   1206 N  NZ   . LYS A 1 121 ? 4.25000  1.24700   25.51100 1.000 65.16403  ? 121 LYS A NZ   1 
ATOM   1207 H  H    . LYS A 1 121 ? 5.02600  6.54400   28.26200 1.000 34.97310  ? 121 LYS A H    1 
ATOM   1208 H  HA   . LYS A 1 121 ? 7.01800  5.98100   29.86700 1.000 34.19514  ? 121 LYS A HA   1 
ATOM   1209 H  HB2  . LYS A 1 121 ? 7.14200  3.93200   28.63100 1.000 39.34542  ? 121 LYS A HB2  1 
ATOM   1210 H  HB3  . LYS A 1 121 ? 5.72200  4.21500   29.28500 1.000 39.34542  ? 121 LYS A HB3  1 
ATOM   1211 H  HG2  . LYS A 1 121 ? 4.86900  4.81100   27.21800 1.000 52.05791  ? 121 LYS A HG2  1 
ATOM   1212 H  HG3  . LYS A 1 121 ? 6.29500  4.59600   26.55200 1.000 52.05791  ? 121 LYS A HG3  1 
ATOM   1213 H  HD2  . LYS A 1 121 ? 6.15000  2.30000   27.29200 1.000 62.34885  ? 121 LYS A HD2  1 
ATOM   1214 H  HD3  . LYS A 1 121 ? 4.61800  2.58800   27.60200 1.000 62.34885  ? 121 LYS A HD3  1 
ATOM   1215 H  HE2  . LYS A 1 121 ? 4.48500  3.23400   25.24100 1.000 67.22940  ? 121 LYS A HE2  1 
ATOM   1216 H  HE3  . LYS A 1 121 ? 5.84000  2.41800   25.08900 1.000 67.22940  ? 121 LYS A HE3  1 
ATOM   1217 H  HZ1  . LYS A 1 121 ? 3.46800  1.33600   25.92600 1.000 78.13660  ? 121 LYS A HZ1  1 
ATOM   1218 H  HZ2  . LYS A 1 121 ? 4.10300  1.04300   24.65800 1.000 78.13660  ? 121 LYS A HZ2  1 
ATOM   1219 H  HZ3  . LYS A 1 121 ? 4.70500  0.58300   25.89200 1.000 78.13660  ? 121 LYS A HZ3  1 
ATOM   1220 N  N    . ASN A 1 122 ? 7.90600  7.06000   27.05500 1.000 27.02345  ? 122 ASN A N    1 
ATOM   1221 C  CA   . ASN A 1 122 ? 9.06300  7.47100   26.27500 1.000 24.69059  ? 122 ASN A CA   1 
ATOM   1222 C  C    . ASN A 1 122 ? 9.61000  8.82400   26.71300 1.000 23.19390  ? 122 ASN A C    1 
ATOM   1223 O  O    . ASN A 1 122 ? 10.49300 9.36700   26.04200 1.000 21.54425  ? 122 ASN A O    1 
ATOM   1224 C  CB   . ASN A 1 122 ? 8.71200  7.50100   24.78500 1.000 28.68607  ? 122 ASN A CB   1 
ATOM   1225 C  CG   . ASN A 1 122 ? 8.35100  6.12900   24.24600 1.000 30.38295  ? 122 ASN A CG   1 
ATOM   1226 O  OD1  . ASN A 1 122 ? 7.31900  5.95600   23.60000 1.000 26.79825  ? 122 ASN A OD1  1 
ATOM   1227 N  ND2  . ASN A 1 122 ? 9.19800  5.14300   24.52200 1.000 28.15534  ? 122 ASN A ND2  1 
ATOM   1228 H  H    . ASN A 1 122 ? 7.15700  7.37200   26.76800 1.000 32.36790  ? 122 ASN A H    1 
ATOM   1229 H  HA   . ASN A 1 122 ? 9.76700  6.81500   26.39500 1.000 29.56846  ? 122 ASN A HA   1 
ATOM   1230 H  HB2  . ASN A 1 122 ? 7.95000  8.08800   24.65100 1.000 34.36305  ? 122 ASN A HB2  1 
ATOM   1231 H  HB3  . ASN A 1 122 ? 9.47500  7.83000   24.28600 1.000 34.36305  ? 122 ASN A HB3  1 
ATOM   1232 H  HD21 . ASN A 1 122 ? 9.03800  4.34700   24.23900 1.000 33.72617  ? 122 ASN A HD21 1 
ATOM   1233 H  HD22 . ASN A 1 122 ? 9.90600  5.30100   24.98300 1.000 33.72617  ? 122 ASN A HD22 1 
ATOM   1234 N  N    . ILE A 1 123 ? 9.11700  9.36900   27.82600 1.000 28.09454  ? 123 ILE A N    1 
ATOM   1235 C  CA   . ILE A 1 123 ? 9.56900  10.65100  28.34900 1.000 23.74806  ? 123 ILE A CA   1 
ATOM   1236 C  C    . ILE A 1 123 ? 10.00400 10.46400  29.79700 1.000 30.71765  ? 123 ILE A C    1 
ATOM   1237 O  O    . ILE A 1 123 ? 9.35600  9.73900   30.56100 1.000 29.61805  ? 123 ILE A O    1 
ATOM   1238 C  CB   . ILE A 1 123 ? 8.46900  11.73200  28.26200 1.000 29.19262  ? 123 ILE A CB   1 
ATOM   1239 C  CG1  . ILE A 1 123 ? 8.08400  12.00500  26.80600 1.000 35.37743  ? 123 ILE A CG1  1 
ATOM   1240 C  CG2  . ILE A 1 123 ? 8.93100  13.00600  28.95800 1.000 32.84840  ? 123 ILE A CG2  1 
ATOM   1241 C  CD1  . ILE A 1 123 ? 9.17800  12.64200  25.97600 1.000 32.43604  ? 123 ILE A CD1  1 
ATOM   1242 H  H    . ILE A 1 123 ? 8.50400  9.00300   28.30500 1.000 33.65321  ? 123 ILE A H    1 
ATOM   1243 H  HA   . ILE A 1 123 ? 10.33300 10.94700  27.83000 1.000 28.43743  ? 123 ILE A HA   1 
ATOM   1244 H  HB   . ILE A 1 123 ? 7.67900  11.40200  28.71700 1.000 34.97090  ? 123 ILE A HB   1 
ATOM   1245 H  HG12 . ILE A 1 123 ? 7.84900  11.16300  26.38600 1.000 42.39268  ? 123 ILE A HG12 1 
ATOM   1246 H  HG13 . ILE A 1 123 ? 7.32200  12.60500  26.79600 1.000 42.39268  ? 123 ILE A HG13 1 
ATOM   1247 H  HG21 . ILE A 1 123 ? 8.40700  13.75300  28.62800 1.000 39.35784  ? 123 ILE A HG21 1 
ATOM   1248 H  HG22 . ILE A 1 123 ? 8.80200  12.90800  29.91400 1.000 39.35784  ? 123 ILE A HG22 1 
ATOM   1249 H  HG23 . ILE A 1 123 ? 9.87000  13.15000  28.76300 1.000 39.35784  ? 123 ILE A HG23 1 
ATOM   1250 H  HD11 . ILE A 1 123 ? 8.82300  12.86300  25.10100 1.000 38.86301  ? 123 ILE A HD11 1 
ATOM   1251 H  HD12 . ILE A 1 123 ? 9.48500  13.44700  26.42100 1.000 38.86301  ? 123 ILE A HD12 1 
ATOM   1252 H  HD13 . ILE A 1 123 ? 9.91200  12.01400  25.88500 1.000 38.86301  ? 123 ILE A HD13 1 
ATOM   1253 N  N    . ILE A 1 124 ? 11.10000 11.12400  30.16700 1.000 25.95741  ? 124 ILE A N    1 
ATOM   1254 C  CA   . ILE A 1 124 ? 11.61500 11.12600  31.53000 1.000 32.84543  ? 124 ILE A CA   1 
ATOM   1255 C  C    . ILE A 1 124 ? 10.48400 11.22800  32.54300 1.000 31.90670  ? 124 ILE A C    1 
ATOM   1256 O  O    . ILE A 1 124 ? 9.55600  12.03100  32.38500 1.000 28.84203  ? 124 ILE A O    1 
ATOM   1257 C  CB   . ILE A 1 124 ? 12.61500 12.28500  31.72600 1.000 34.13716  ? 124 ILE A CB   1 
ATOM   1258 C  CG1  . ILE A 1 124 ? 13.09900 12.35800  33.17400 1.000 34.38745  ? 124 ILE A CG1  1 
ATOM   1259 C  CG2  . ILE A 1 124 ? 11.98100 13.61300  31.34200 1.000 34.56896  ? 124 ILE A CG2  1 
ATOM   1260 C  CD1  . ILE A 1 124 ? 13.91900 11.20100  33.57200 1.000 46.25429  ? 124 ILE A CD1  1 
ATOM   1261 H  H    . ILE A 1 124 ? 11.57800 11.59300  29.62700 1.000 31.08866  ? 124 ILE A H    1 
ATOM   1262 H  HA   . ILE A 1 124 ? 12.06000 10.27800  31.68300 1.000 39.35428  ? 124 ILE A HA   1 
ATOM   1263 H  HB   . ILE A 1 124 ? 13.37400 12.10900  31.14800 1.000 40.90436  ? 124 ILE A HB   1 
ATOM   1264 H  HG12 . ILE A 1 124 ? 13.63800 13.15700  33.28500 1.000 41.20471  ? 124 ILE A HG12 1 
ATOM   1265 H  HG13 . ILE A 1 124 ? 12.32800 12.39300  33.76100 1.000 41.20471  ? 124 ILE A HG13 1 
ATOM   1266 H  HG21 . ILE A 1 124 ? 12.64100 14.31800  31.43800 1.000 41.42251  ? 124 ILE A HG21 1 
ATOM   1267 H  HG22 . ILE A 1 124 ? 11.68100 13.56500  30.42100 1.000 41.42251  ? 124 ILE A HG22 1 
ATOM   1268 H  HG23 . ILE A 1 124 ? 11.22700 13.78400  31.92700 1.000 41.42251  ? 124 ILE A HG23 1 
ATOM   1269 H  HD11 . ILE A 1 124 ? 14.39100 11.41500  34.39100 1.000 55.44491  ? 124 ILE A HD11 1 
ATOM   1270 H  HD12 . ILE A 1 124 ? 13.33800 10.43700  33.71400 1.000 55.44491  ? 124 ILE A HD12 1 
ATOM   1271 H  HD13 . ILE A 1 124 ? 14.55400 11.00700  32.86500 1.000 55.44491  ? 124 ILE A HD13 1 
ATOM   1272 N  N    . SER A 1 125 ? 10.55900 10.40700  33.58900 1.000 32.98099  ? 125 SER A N    1 
ATOM   1273 C  CA   . SER A 1 125 ? 9.74800  10.57100  34.78900 1.000 36.08000  ? 125 SER A CA   1 
ATOM   1274 C  C    . SER A 1 125 ? 10.64900 10.31500  35.98700 1.000 28.71213  ? 125 SER A C    1 
ATOM   1275 O  O    . SER A 1 125 ? 11.38600 9.32500   36.00600 1.000 37.08689  ? 125 SER A O    1 
ATOM   1276 C  CB   . SER A 1 125 ? 8.55100  9.61600   34.80300 1.000 45.53459  ? 125 SER A CB   1 
ATOM   1277 O  OG   . SER A 1 125 ? 8.97300  8.26400   34.82500 1.000 51.00427  ? 125 SER A OG   1 
ATOM   1278 H  H    . SER A 1 125 ? 11.08800 9.73000   33.62700 1.000 39.51695  ? 125 SER A H    1 
ATOM   1279 H  HA   . SER A 1 125 ? 9.39500  11.47300  34.83600 1.000 43.23576  ? 125 SER A HA   1 
ATOM   1280 H  HB2  . SER A 1 125 ? 8.01700  9.79200   35.59400 1.000 54.58127  ? 125 SER A HB2  1 
ATOM   1281 H  HB3  . SER A 1 125 ? 8.02000  9.76600   34.00500 1.000 54.58127  ? 125 SER A HB3  1 
ATOM   1282 H  HG   . SER A 1 125 ? 9.38200  8.10300   35.54100 1.000 61.14489  ? 125 SER A HG   1 
ATOM   1283 N  N    . LEU A 1 126 ? 10.60500 11.20400  36.97500 1.000 22.96873  ? 126 LEU A N    1 
ATOM   1284 C  CA   . LEU A 1 126 ? 11.49600 11.09700  38.11900 1.000 26.86757  ? 126 LEU A CA   1 
ATOM   1285 C  C    . LEU A 1 126 ? 10.92600 10.16000  39.17300 1.000 29.01773  ? 126 LEU A C    1 
ATOM   1286 O  O    . LEU A 1 126 ? 9.71300  10.11700  39.39600 1.000 32.67426  ? 126 LEU A O    1 
ATOM   1287 C  CB   . LEU A 1 126 ? 11.74700 12.46000  38.75800 1.000 30.25796  ? 126 LEU A CB   1 
ATOM   1288 C  CG   . LEU A 1 126 ? 12.38500 13.49800  37.84400 1.000 34.02151  ? 126 LEU A CG   1 
ATOM   1289 C  CD1  . LEU A 1 126 ? 12.58400 14.80800  38.57800 1.000 36.29637  ? 126 LEU A CD1  1 
ATOM   1290 C  CD2  . LEU A 1 126 ? 13.70300 13.00000  37.26300 1.000 34.90833  ? 126 LEU A CD2  1 
ATOM   1291 H  H    . LEU A 1 126 ? 10.06900 11.87500  37.00300 1.000 27.50224  ? 126 LEU A H    1 
ATOM   1292 H  HA   . LEU A 1 126 ? 12.34100 10.73700  37.80400 1.000 32.18084  ? 126 LEU A HA   1 
ATOM   1293 H  HB2  . LEU A 1 126 ? 10.89600 12.81800  39.05600 1.000 36.24932  ? 126 LEU A HB2  1 
ATOM   1294 H  HB3  . LEU A 1 126 ? 12.33900 12.33700  39.51600 1.000 36.24932  ? 126 LEU A HB3  1 
ATOM   1295 H  HG   . LEU A 1 126 ? 11.78300 13.65700  37.10000 1.000 40.76558  ? 126 LEU A HG   1 
ATOM   1296 H  HD11 . LEU A 1 126 ? 13.31000 15.29700  38.16000 1.000 43.49541  ? 126 LEU A HD11 1 
ATOM   1297 H  HD12 . LEU A 1 126 ? 11.76500 15.32500  38.52900 1.000 43.49541  ? 126 LEU A HD12 1 
ATOM   1298 H  HD13 . LEU A 1 126 ? 12.80200 14.62100  39.50500 1.000 43.49541  ? 126 LEU A HD13 1 
ATOM   1299 H  HD21 . LEU A 1 126 ? 14.11800 13.71800  36.76000 1.000 41.82976  ? 126 LEU A HD21 1 
ATOM   1300 H  HD22 . LEU A 1 126 ? 14.28500 12.72600  37.99000 1.000 41.82976  ? 126 LEU A HD22 1 
ATOM   1301 H  HD23 . LEU A 1 126 ? 13.52600 12.24600  36.67900 1.000 41.82976  ? 126 LEU A HD23 1 
ATOM   1302 N  N    . LEU A 1 127 ? 11.82000 9.42400   39.82700 1.000 26.18623  ? 127 LEU A N    1 
ATOM   1303 C  CA   . LEU A 1 127 ? 11.46100 8.65100   41.00600 1.000 30.55744  ? 127 LEU A CA   1 
ATOM   1304 C  C    . LEU A 1 127 ? 11.58300 9.46700   42.28200 1.000 32.01399  ? 127 LEU A C    1 
ATOM   1305 O  O    . LEU A 1 127 ? 10.88200 9.18400   43.26000 1.000 28.71340  ? 127 LEU A O    1 
ATOM   1306 C  CB   . LEU A 1 127 ? 12.35300 7.41600   41.11800 1.000 29.41056  ? 127 LEU A CB   1 
ATOM   1307 C  CG   . LEU A 1 127 ? 12.28100 6.43700   39.94700 1.000 27.43031  ? 127 LEU A CG   1 
ATOM   1308 C  CD1  . LEU A 1 127 ? 13.39500 5.41400   40.05400 1.000 30.85656  ? 127 LEU A CD1  1 
ATOM   1309 C  CD2  . LEU A 1 127 ? 10.92400 5.75900   39.91200 1.000 39.22085  ? 127 LEU A CD2  1 
ATOM   1310 H  H    . LEU A 1 127 ? 12.64800 9.35600   39.60400 1.000 31.36323  ? 127 LEU A H    1 
ATOM   1311 H  HA   . LEU A 1 127 ? 10.54300 8.35000   40.91800 1.000 36.60869  ? 127 LEU A HA   1 
ATOM   1312 H  HB2  . LEU A 1 127 ? 13.27400 7.71200   41.19000 1.000 35.23243  ? 127 LEU A HB2  1 
ATOM   1313 H  HB3  . LEU A 1 127 ? 12.09800 6.92900   41.91700 1.000 35.23243  ? 127 LEU A HB3  1 
ATOM   1314 H  HG   . LEU A 1 127 ? 12.39400 6.91900   39.11200 1.000 32.85613  ? 127 LEU A HG   1 
ATOM   1315 H  HD11 . LEU A 1 127 ? 13.30300 4.77100   39.33400 1.000 36.96764  ? 127 LEU A HD11 1 
ATOM   1316 H  HD12 . LEU A 1 127 ? 14.24900 5.86900   39.98600 1.000 36.96764  ? 127 LEU A HD12 1 
ATOM   1317 H  HD13 . LEU A 1 127 ? 13.32800 4.96400   40.91100 1.000 36.96764  ? 127 LEU A HD13 1 
ATOM   1318 H  HD21 . LEU A 1 127 ? 10.92700 5.08300   39.21700 1.000 47.00478  ? 127 LEU A HD21 1 
ATOM   1319 H  HD22 . LEU A 1 127 ? 10.75500 5.34700   40.77400 1.000 47.00478  ? 127 LEU A HD22 1 
ATOM   1320 H  HD23 . LEU A 1 127 ? 10.24300 6.42400   39.72500 1.000 47.00478  ? 127 LEU A HD23 1 
ATOM   1321 N  N    . ASN A 1 128 ? 12.45400 10.47400  42.28900 1.000 27.92147  ? 128 ASN A N    1 
ATOM   1322 C  CA   . ASN A 1 128 ? 12.70500 11.24500  43.49700 1.000 21.24048  ? 128 ASN A CA   1 
ATOM   1323 C  C    . ASN A 1 128 ? 13.38500 12.55700  43.14000 1.000 26.56589  ? 128 ASN A C    1 
ATOM   1324 O  O    . ASN A 1 128 ? 14.06000 12.66800  42.11300 1.000 22.33949  ? 128 ASN A O    1 
ATOM   1325 C  CB   . ASN A 1 128 ? 13.58100 10.46300  44.47900 1.000 28.03795  ? 128 ASN A CB   1 
ATOM   1326 C  CG   . ASN A 1 128 ? 13.39800 10.91500  45.91000 1.000 26.61982  ? 128 ASN A CG   1 
ATOM   1327 O  OD1  . ASN A 1 128 ? 12.68100 11.87700  46.18100 1.000 30.72077  ? 128 ASN A OD1  1 
ATOM   1328 N  ND2  . ASN A 1 128 ? 14.05900 10.23200  46.83300 1.000 27.93496  ? 128 ASN A ND2  1 
ATOM   1329 H  H    . ASN A 1 128 ? 12.91000 10.72900  41.60500 1.000 33.44552  ? 128 ASN A H    1 
ATOM   1330 H  HA   . ASN A 1 128 ? 11.85600 11.45000  43.91700 1.000 25.42834  ? 128 ASN A HA   1 
ATOM   1331 H  HB2  . ASN A 1 128 ? 13.35000 9.52200   44.43000 1.000 33.58530  ? 128 ASN A HB2  1 
ATOM   1332 H  HB3  . ASN A 1 128 ? 14.51300 10.58900  44.24200 1.000 33.58530  ? 128 ASN A HB3  1 
ATOM   1333 H  HD21 . ASN A 1 128 ? 13.98900 10.44900  47.66200 1.000 33.46171  ? 128 ASN A HD21 1 
ATOM   1334 H  HD22 . ASN A 1 128 ? 14.55900 9.57100   46.60300 1.000 33.46171  ? 128 ASN A HD22 1 
ATOM   1335 N  N    . VAL A 1 129 ? 13.19600 13.54100  44.01400 1.000 25.97046  ? 129 VAL A N    1 
ATOM   1336 C  CA   . VAL A 1 129 ? 13.89800 14.81900  43.96900 1.000 31.93627  ? 129 VAL A CA   1 
ATOM   1337 C  C    . VAL A 1 129 ? 14.21000 15.19700  45.41000 1.000 30.17491  ? 129 VAL A C    1 
ATOM   1338 O  O    . VAL A 1 129 ? 13.33400 15.10500  46.27400 1.000 29.97751  ? 129 VAL A O    1 
ATOM   1339 C  CB   . VAL A 1 129 ? 13.06200 15.92500  43.30100 1.000 21.35203  ? 129 VAL A CB   1 
ATOM   1340 C  CG1  . VAL A 1 129 ? 13.86000 17.22300  43.21800 1.000 29.31905  ? 129 VAL A CG1  1 
ATOM   1341 C  CG2  . VAL A 1 129 ? 12.60700 15.48600  41.93500 1.000 34.80323  ? 129 VAL A CG2  1 
ATOM   1342 H  H    . VAL A 1 129 ? 12.64300 13.49000  44.67100 1.000 31.10431  ? 129 VAL A H    1 
ATOM   1343 H  HA   . VAL A 1 129 ? 14.72100 14.72600  43.46400 1.000 38.26329  ? 129 VAL A HA   1 
ATOM   1344 H  HB   . VAL A 1 129 ? 12.27300 16.09400  43.83900 1.000 25.56220  ? 129 VAL A HB   1 
ATOM   1345 H  HG11 . VAL A 1 129 ? 13.42700 17.82000  42.58900 1.000 35.12262  ? 129 VAL A HG11 1 
ATOM   1346 H  HG12 . VAL A 1 129 ? 13.88800 17.63200  44.09700 1.000 35.12262  ? 129 VAL A HG12 1 
ATOM   1347 H  HG13 . VAL A 1 129 ? 14.76000 17.02100  42.91800 1.000 35.12262  ? 129 VAL A HG13 1 
ATOM   1348 H  HG21 . VAL A 1 129 ? 12.16300 16.22900  41.49600 1.000 41.70364  ? 129 VAL A HG21 1 
ATOM   1349 H  HG22 . VAL A 1 129 ? 13.38000 15.21000  41.41800 1.000 41.70364  ? 129 VAL A HG22 1 
ATOM   1350 H  HG23 . VAL A 1 129 ? 11.99100 14.74300  42.03100 1.000 41.70364  ? 129 VAL A HG23 1 
ATOM   1351 N  N    . PHE A 1 130 ? 15.44500 15.60700  45.67500 1.000 25.51728  ? 130 PHE A N    1 
ATOM   1352 C  CA   . PHE A 1 130 ? 15.79400 15.97000  47.04000 1.000 32.81878  ? 130 PHE A CA   1 
ATOM   1353 C  C    . PHE A 1 130 ? 16.99900 16.89400  47.04100 1.000 29.93422  ? 130 PHE A C    1 
ATOM   1354 O  O    . PHE A 1 130 ? 17.76000 16.97200  46.07300 1.000 23.62154  ? 130 PHE A O    1 
ATOM   1355 C  CB   . PHE A 1 130 ? 16.06300 14.72100  47.89900 1.000 27.66335  ? 130 PHE A CB   1 
ATOM   1356 C  CG   . PHE A 1 130 ? 17.26600 13.92300  47.46700 1.000 24.98171  ? 130 PHE A CG   1 
ATOM   1357 C  CD1  . PHE A 1 130 ? 18.53500 14.25100  47.91700 1.000 24.16528  ? 130 PHE A CD1  1 
ATOM   1358 C  CD2  . PHE A 1 130 ? 17.12500 12.83500  46.62000 1.000 25.73296  ? 130 PHE A CD2  1 
ATOM   1359 C  CE1  . PHE A 1 130 ? 19.63700 13.51600  47.52800 1.000 24.38486  ? 130 PHE A CE1  1 
ATOM   1360 C  CE2  . PHE A 1 130 ? 18.22600 12.09600  46.22700 1.000 24.28935  ? 130 PHE A CE2  1 
ATOM   1361 C  CZ   . PHE A 1 130 ? 19.48100 12.43600  46.68000 1.000 24.74825  ? 130 PHE A CZ   1 
ATOM   1362 H  H    . PHE A 1 130 ? 16.07900 15.68000  45.09900 1.000 30.56049  ? 130 PHE A H    1 
ATOM   1363 H  HA   . PHE A 1 130 ? 15.05400 16.46300  47.42700 1.000 39.32229  ? 130 PHE A HA   1 
ATOM   1364 H  HB2  . PHE A 1 130 ? 16.21000 15.00200  48.81600 1.000 33.13578  ? 130 PHE A HB2  1 
ATOM   1365 H  HB3  . PHE A 1 130 ? 15.29000 14.13800  47.85000 1.000 33.13578  ? 130 PHE A HB3  1 
ATOM   1366 H  HD1  . PHE A 1 130 ? 18.64500 14.97500  48.48900 1.000 28.93809  ? 130 PHE A HD1  1 
ATOM   1367 H  HD2  . PHE A 1 130 ? 16.28000 12.59900  46.31200 1.000 30.81931  ? 130 PHE A HD2  1 
ATOM   1368 H  HE1  . PHE A 1 130 ? 20.48400 13.74800  47.83500 1.000 29.20160  ? 130 PHE A HE1  1 
ATOM   1369 H  HE2  . PHE A 1 130 ? 18.11900 11.37000  45.65700 1.000 29.08698  ? 130 PHE A HE2  1 
ATOM   1370 H  HZ   . PHE A 1 130 ? 20.22200 11.94000  46.41600 1.000 29.63766  ? 130 PHE A HZ   1 
ATOM   1371 N  N    . THR A 1 131 ? 17.13700 17.62200  48.14500 1.000 27.77410  ? 131 THR A N    1 
ATOM   1372 C  CA   . THR A 1 131 ? 18.33900 18.36300  48.46900 1.000 20.67391  ? 131 THR A CA   1 
ATOM   1373 C  C    . THR A 1 131 ? 18.77100 17.95500  49.87000 1.000 26.43090  ? 131 THR A C    1 
ATOM   1374 O  O    . THR A 1 131 ? 17.92100 17.80100  50.75600 1.000 25.03776  ? 131 THR A O    1 
ATOM   1375 C  CB   . THR A 1 131 ? 18.10900 19.88300  48.41100 1.000 22.40167  ? 131 THR A CB   1 
ATOM   1376 O  OG1  . THR A 1 131 ? 19.30700 20.56500  48.80400 1.000 27.51250  ? 131 THR A OG1  1 
ATOM   1377 C  CG2  . THR A 1 131 ? 16.97100 20.30500  49.32400 1.000 33.34974  ? 131 THR A CG2  1 
ATOM   1378 H  H    . THR A 1 131 ? 16.52300 17.70100  48.74100 1.000 33.26869  ? 131 THR A H    1 
ATOM   1379 H  HA   . THR A 1 131 ? 19.04200 18.16300  47.83100 1.000 24.74845  ? 131 THR A HA   1 
ATOM   1380 H  HB   . THR A 1 131 ? 17.87200 20.13100  47.50400 1.000 26.82177  ? 131 THR A HB   1 
ATOM   1381 H  HG1  . THR A 1 131 ? 19.90700 20.44800  48.22800 1.000 32.95476  ? 131 THR A HG1  1 
ATOM   1382 H  HG21 . THR A 1 131 ? 16.75000 21.23600  49.17000 1.000 39.95944  ? 131 THR A HG21 1 
ATOM   1383 H  HG22 . THR A 1 131 ? 16.18600 19.76200  49.14900 1.000 39.95944  ? 131 THR A HG22 1 
ATOM   1384 H  HG23 . THR A 1 131 ? 17.23000 20.19200  50.25200 1.000 39.95944  ? 131 THR A HG23 1 
ATOM   1385 N  N    . PRO A 1 132 ? 20.06800 17.73700  50.10000 1.000 26.44251  ? 132 PRO A N    1 
ATOM   1386 C  CA   . PRO A 1 132 ? 20.51900 17.46100  51.47000 1.000 27.84986  ? 132 PRO A CA   1 
ATOM   1387 C  C    . PRO A 1 132 ? 20.54300 18.69500  52.34200 1.000 35.29325  ? 132 PRO A C    1 
ATOM   1388 O  O    . PRO A 1 132 ? 20.66800 18.56300  53.56500 1.000 33.36200  ? 132 PRO A O    1 
ATOM   1389 C  CB   . PRO A 1 132 ? 21.92600 16.88700  51.27500 1.000 32.54738  ? 132 PRO A CB   1 
ATOM   1390 C  CG   . PRO A 1 132 ? 22.38900 17.43300  49.98200 1.000 36.60222  ? 132 PRO A CG   1 
ATOM   1391 C  CD   . PRO A 1 132 ? 21.17800 17.71400  49.13100 1.000 29.19039  ? 132 PRO A CD   1 
ATOM   1392 H  HA   . PRO A 1 132 ? 19.96400 16.78000  51.88200 1.000 33.35960  ? 132 PRO A HA   1 
ATOM   1393 H  HB2  . PRO A 1 132 ? 22.50300 17.17600  51.99900 1.000 38.99662  ? 132 PRO A HB2  1 
ATOM   1394 H  HB3  . PRO A 1 132 ? 21.88600 15.91900  51.24800 1.000 38.99662  ? 132 PRO A HB3  1 
ATOM   1395 H  HG2  . PRO A 1 132 ? 22.88400 18.25200  50.14100 1.000 43.86242  ? 132 PRO A HG2  1 
ATOM   1396 H  HG3  . PRO A 1 132 ? 22.95900 16.78000  49.54700 1.000 43.86242  ? 132 PRO A HG3  1 
ATOM   1397 H  HD2  . PRO A 1 132 ? 21.26300 18.57200  48.68600 1.000 34.96822  ? 132 PRO A HD2  1 
ATOM   1398 H  HD3  . PRO A 1 132 ? 21.04800 17.01100  48.47600 1.000 34.96822  ? 132 PRO A HD3  1 
ATOM   1399 N  N    . GLN A 1 133 ? 20.41700 19.88300  51.75900 1.000 30.21787  ? 133 GLN A N    1 
ATOM   1400 C  CA   . GLN A 1 133 ? 20.40400 21.10300  52.55000 1.000 34.07660  ? 133 GLN A CA   1 
ATOM   1401 C  C    . GLN A 1 133 ? 19.02500 21.32400  53.16300 1.000 39.83910  ? 133 GLN A C    1 
ATOM   1402 O  O    . GLN A 1 133 ? 17.99800 20.89700  52.63000 1.000 37.49804  ? 133 GLN A O    1 
ATOM   1403 C  CB   . GLN A 1 133 ? 20.82800 22.29700  51.69900 1.000 36.51828  ? 133 GLN A CB   1 
ATOM   1404 C  CG   . GLN A 1 133 ? 22.31500 22.26600  51.34600 1.000 35.23896  ? 133 GLN A CG   1 
ATOM   1405 C  CD   . GLN A 1 133 ? 22.60400 21.57000  50.02900 1.000 40.09225  ? 133 GLN A CD   1 
ATOM   1406 O  OE1  . GLN A 1 133 ? 21.93300 21.80600  49.02300 1.000 28.61201  ? 133 GLN A OE1  1 
ATOM   1407 N  NE2  . GLN A 1 133 ? 23.61800 20.71100  50.02800 1.000 34.63032  ? 133 GLN A NE2  1 
ATOM   1408 H  H    . GLN A 1 133 ? 20.33900 20.00600  50.91200 1.000 36.20120  ? 133 GLN A H    1 
ATOM   1409 H  HA   . GLN A 1 133 ? 21.03900 21.03400  53.28100 1.000 40.83168  ? 133 GLN A HA   1 
ATOM   1410 H  HB2  . GLN A 1 133 ? 20.32200 22.29100  50.87200 1.000 43.76170  ? 133 GLN A HB2  1 
ATOM   1411 H  HB3  . GLN A 1 133 ? 20.65200 23.11400  52.19100 1.000 43.76170  ? 133 GLN A HB3  1 
ATOM   1412 H  HG2  . GLN A 1 133 ? 22.64000 23.17800  51.27800 1.000 42.22651  ? 133 GLN A HG2  1 
ATOM   1413 H  HG3  . GLN A 1 133 ? 22.79400 21.79400  52.04400 1.000 42.22651  ? 133 GLN A HG3  1 
ATOM   1414 H  HE21 . GLN A 1 133 ? 24.06900 20.57700  50.74800 1.000 41.49615  ? 133 GLN A HE21 1 
ATOM   1415 H  HE22 . GLN A 1 133 ? 23.82400 20.29000  49.30700 1.000 41.49615  ? 133 GLN A HE22 1 
ATOM   1416 N  N    . LYS A 1 134 ? 19.02200 22.02600  54.29600 1.000 47.09837  ? 134 LYS A N    1 
ATOM   1417 C  CA   . LYS A 1 134 ? 17.94200 21.96500  55.26800 1.000 45.50706  ? 134 LYS A CA   1 
ATOM   1418 C  C    . LYS A 1 134 ? 17.01400 23.16500  55.19500 1.000 41.66783  ? 134 LYS A C    1 
ATOM   1419 O  O    . LYS A 1 134 ? 15.82100 23.03300  55.48500 1.000 49.46421  ? 134 LYS A O    1 
ATOM   1420 C  CB   . LYS A 1 134 ? 18.51000 21.87900  56.69900 1.000 49.00093  ? 134 LYS A CB   1 
ATOM   1421 C  CG   . LYS A 1 134 ? 19.58400 20.79500  56.99500 1.000 57.72671  ? 134 LYS A CG   1 
ATOM   1422 C  CD   . LYS A 1 134 ? 20.81400 20.82900  56.07800 1.000 59.98793  ? 134 LYS A CD   1 
ATOM   1423 C  CE   . LYS A 1 134 ? 21.50200 22.19900  56.05800 1.000 54.03827  ? 134 LYS A CE   1 
ATOM   1424 N  NZ   . LYS A 1 134 ? 22.65500 22.26300  55.10900 1.000 45.85966  ? 134 LYS A NZ   1 
ATOM   1425 H  H    . LYS A 1 134 ? 19.65600 22.56000  54.52800 1.000 56.45780  ? 134 LYS A H    1 
ATOM   1426 H  HA   . LYS A 1 134 ? 17.42300 21.16300  55.10300 1.000 54.54823  ? 134 LYS A HA   1 
ATOM   1427 H  HB2  . LYS A 1 134 ? 18.91500 22.73600  56.90800 1.000 58.74087  ? 134 LYS A HB2  1 
ATOM   1428 H  HB3  . LYS A 1 134 ? 17.76900 21.70700  57.30100 1.000 58.74087  ? 134 LYS A HB3  1 
ATOM   1429 H  HG2  . LYS A 1 134 ? 19.89800 20.91500  57.90500 1.000 69.21181  ? 134 LYS A HG2  1 
ATOM   1430 H  HG3  . LYS A 1 134 ? 19.17400 19.92200  56.89800 1.000 69.21181  ? 134 LYS A HG3  1 
ATOM   1431 H  HD2  . LYS A 1 134 ? 21.45900 20.17500  56.39000 1.000 71.92528  ? 134 LYS A HD2  1 
ATOM   1432 H  HD3  . LYS A 1 134 ? 20.53900 20.61800  55.17200 1.000 71.92528  ? 134 LYS A HD3  1 
ATOM   1433 H  HE2  . LYS A 1 134 ? 20.85700 22.87200  55.78800 1.000 64.78569  ? 134 LYS A HE2  1 
ATOM   1434 H  HE3  . LYS A 1 134 ? 21.83600 22.39800  56.94700 1.000 64.78569  ? 134 LYS A HE3  1 
ATOM   1435 H  HZ1  . LYS A 1 134 ? 23.02500 23.07100  55.13400 1.000 54.97135  ? 134 LYS A HZ1  1 
ATOM   1436 H  HZ2  . LYS A 1 134 ? 23.26800 21.65800  55.33400 1.000 54.97135  ? 134 LYS A HZ2  1 
ATOM   1437 H  HZ3  . LYS A 1 134 ? 22.37600 22.09700  54.28000 1.000 54.97135  ? 134 LYS A HZ3  1 
ATOM   1438 N  N    . THR A 1 135 ? 17.54100 24.32500  54.82000 1.000 40.71553  ? 135 THR A N    1 
ATOM   1439 C  CA   . THR A 1 135 ? 16.78300 25.56100  54.73200 1.000 40.45566  ? 135 THR A CA   1 
ATOM   1440 C  C    . THR A 1 135 ? 17.11000 26.23100  53.40700 1.000 33.13290  ? 135 THR A C    1 
ATOM   1441 O  O    . THR A 1 135 ? 18.03100 25.82700  52.69300 1.000 31.67484  ? 135 THR A O    1 
ATOM   1442 C  CB   . THR A 1 135 ? 17.11300 26.51000  55.89100 1.000 42.02747  ? 135 THR A CB   1 
ATOM   1443 O  OG1  . THR A 1 135 ? 18.42600 27.04900  55.69900 1.000 43.58985  ? 135 THR A OG1  1 
ATOM   1444 C  CG2  . THR A 1 135 ? 17.06700 25.77700  57.22300 1.000 37.63121  ? 135 THR A CG2  1 
ATOM   1445 H  H    . THR A 1 135 ? 18.36800 24.42200  54.60400 1.000 48.79840  ? 135 THR A H    1 
ATOM   1446 H  HA   . THR A 1 135 ? 15.83400 25.36300  54.76500 1.000 48.48655  ? 135 THR A HA   1 
ATOM   1447 H  HB   . THR A 1 135 ? 16.45900 27.22600  55.91600 1.000 50.37272  ? 135 THR A HB   1 
ATOM   1448 H  HG1  . THR A 1 135 ? 18.90100 26.50300  55.27400 1.000 52.24759  ? 135 THR A HG1  1 
ATOM   1449 H  HG21 . THR A 1 135 ? 17.23900 26.39700  57.94900 1.000 45.09721  ? 135 THR A HG21 1 
ATOM   1450 H  HG22 . THR A 1 135 ? 16.19200 25.37700  57.35200 1.000 45.09721  ? 135 THR A HG22 1 
ATOM   1451 H  HG23 . THR A 1 135 ? 17.73800 25.07800  57.24000 1.000 45.09721  ? 135 THR A HG23 1 
ATOM   1452 N  N    . LEU A 1 136 ? 16.35600 27.28400  53.09000 1.000 40.57834  ? 136 LEU A N    1 
ATOM   1453 C  CA   . LEU A 1 136 ? 16.62400 28.02800  51.86500 1.000 37.06727  ? 136 LEU A CA   1 
ATOM   1454 C  C    . LEU A 1 136 ? 17.99700 28.69000  51.90800 1.000 42.04197  ? 136 LEU A C    1 
ATOM   1455 O  O    . LEU A 1 136 ? 18.72200 28.69200  50.90800 1.000 30.12661  ? 136 LEU A O    1 
ATOM   1456 C  CB   . LEU A 1 136 ? 15.52900 29.06700  51.63600 1.000 42.86506  ? 136 LEU A CB   1 
ATOM   1457 C  CG   . LEU A 1 136 ? 15.68900 29.95800  50.40500 1.000 38.77422  ? 136 LEU A CG   1 
ATOM   1458 C  CD1  . LEU A 1 136 ? 15.47400 29.17200  49.11600 1.000 34.62762  ? 136 LEU A CD1  1 
ATOM   1459 C  CD2  . LEU A 1 136 ? 14.72100 31.13000  50.49000 1.000 53.44201  ? 136 LEU A CD2  1 
ATOM   1460 H  H    . LEU A 1 136 ? 15.69800 27.58000  53.55800 1.000 48.63377  ? 136 LEU A H    1 
ATOM   1461 H  HA   . LEU A 1 136 ? 16.61400 27.41200  51.11500 1.000 44.42049  ? 136 LEU A HA   1 
ATOM   1462 H  HB2  . LEU A 1 136 ? 14.68400 28.59900  51.54200 1.000 51.37783  ? 136 LEU A HB2  1 
ATOM   1463 H  HB3  . LEU A 1 136 ? 15.50000 29.65000  52.41000 1.000 51.37783  ? 136 LEU A HB3  1 
ATOM   1464 H  HG   . LEU A 1 136 ? 16.59500 30.30200  50.38100 1.000 46.46882  ? 136 LEU A HG   1 
ATOM   1465 H  HD11 . LEU A 1 136 ? 15.60200 29.76600  48.36000 1.000 41.49290  ? 136 LEU A HD11 1 
ATOM   1466 H  HD12 . LEU A 1 136 ? 16.11500 28.44500  49.07900 1.000 41.49290  ? 136 LEU A HD12 1 
ATOM   1467 H  HD13 . LEU A 1 136 ? 14.57100 28.81700  49.10900 1.000 41.49290  ? 136 LEU A HD13 1 
ATOM   1468 H  HD21 . LEU A 1 136 ? 14.83400 31.68900  49.70600 1.000 64.07017  ? 136 LEU A HD21 1 
ATOM   1469 H  HD22 . LEU A 1 136 ? 13.81400 30.78800  50.52500 1.000 64.07017  ? 136 LEU A HD22 1 
ATOM   1470 H  HD23 . LEU A 1 136 ? 14.91300 31.64100  51.29100 1.000 64.07017  ? 136 LEU A HD23 1 
ATOM   1471 N  N    . GLU A 1 137 ? 18.37800 29.25300  53.05900 1.000 40.56162  ? 137 GLU A N    1 
ATOM   1472 C  CA   . GLU A 1 137 ? 19.65500 29.95900  53.12400 1.000 42.99837  ? 137 GLU A CA   1 
ATOM   1473 C  C    . GLU A 1 137 ? 20.83800 29.01300  52.93100 1.000 37.32181  ? 137 GLU A C    1 
ATOM   1474 O  O    . GLU A 1 137 ? 21.88900 29.43800  52.43900 1.000 44.49697  ? 137 GLU A O    1 
ATOM   1475 C  CB   . GLU A 1 137 ? 19.79600 30.70800  54.45500 1.000 55.02039  ? 137 GLU A CB   1 
ATOM   1476 C  CG   . GLU A 1 137 ? 18.63200 31.63500  54.80600 1.000 53.23150  ? 137 GLU A CG   1 
ATOM   1477 C  CD   . GLU A 1 137 ? 17.48700 30.91900  55.49700 1.000 67.56915  ? 137 GLU A CD   1 
ATOM   1478 O  OE1  . GLU A 1 137 ? 16.69500 30.24600  54.80300 1.000 61.43471  ? 137 GLU A OE1  1 
ATOM   1479 O  OE2  . GLU A 1 137 ? 17.37800 31.03000  56.73700 1.000 81.17690  ? 137 GLU A OE2  1 
ATOM   1480 H  H    . GLU A 1 137 ? 17.92800 29.24000  53.79200 1.000 48.61370  ? 137 GLU A H    1 
ATOM   1481 H  HA   . GLU A 1 137 ? 19.67100 30.61600  52.41100 1.000 51.53781  ? 137 GLU A HA   1 
ATOM   1482 H  HB2  . GLU A 1 137 ? 19.87100 30.05400  55.16700 1.000 65.96423  ? 137 GLU A HB2  1 
ATOM   1483 H  HB3  . GLU A 1 137 ? 20.59800 31.25100  54.41700 1.000 65.96423  ? 137 GLU A HB3  1 
ATOM   1484 H  HG2  . GLU A 1 137 ? 18.95300 32.33000  55.40200 1.000 63.81757  ? 137 GLU A HG2  1 
ATOM   1485 H  HG3  . GLU A 1 137 ? 18.28800 32.03100  53.99000 1.000 63.81757  ? 137 GLU A HG3  1 
ATOM   1486 N  N    . GLU A 1 138 ? 20.69300 27.74100  53.30100 1.000 32.03668  ? 138 GLU A N    1 
ATOM   1487 C  CA   . GLU A 1 138 ? 21.75500 26.76000  53.11700 1.000 32.61374  ? 138 GLU A CA   1 
ATOM   1488 C  C    . GLU A 1 138 ? 21.69400 26.05900  51.76400 1.000 38.62926  ? 138 GLU A C    1 
ATOM   1489 O  O    . GLU A 1 138 ? 22.66900 25.40600  51.37800 1.000 38.26711  ? 138 GLU A O    1 
ATOM   1490 C  CB   . GLU A 1 138 ? 21.69100 25.70900  54.23100 1.000 38.40206  ? 138 GLU A CB   1 
ATOM   1491 C  CG   . GLU A 1 138 ? 21.66400 26.29400  55.63400 1.000 53.59807  ? 138 GLU A CG   1 
ATOM   1492 C  CD   . GLU A 1 138 ? 22.12700 25.30400  56.68400 1.000 58.30198  ? 138 GLU A CD   1 
ATOM   1493 O  OE1  . GLU A 1 138 ? 23.34800 25.05300  56.77400 1.000 70.60294  ? 138 GLU A OE1  1 
ATOM   1494 O  OE2  . GLU A 1 138 ? 21.26600 24.77100  57.41200 1.000 58.71335  ? 138 GLU A OE2  1 
ATOM   1495 H  H    . GLU A 1 138 ? 19.98200 27.42100  53.66300 1.000 38.38377  ? 138 GLU A H    1 
ATOM   1496 H  HA   . GLU A 1 138 ? 22.61000 27.21300  53.17700 1.000 39.07625  ? 138 GLU A HA   1 
ATOM   1497 H  HB2  . GLU A 1 138 ? 20.88500 25.18300  54.11600 1.000 46.02224  ? 138 GLU A HB2  1 
ATOM   1498 H  HB3  . GLU A 1 138 ? 22.47200 25.13800  54.16500 1.000 46.02224  ? 138 GLU A HB3  1 
ATOM   1499 H  HG2  . GLU A 1 138 ? 22.25200 27.06500  55.66800 1.000 64.25745  ? 138 GLU A HG2  1 
ATOM   1500 H  HG3  . GLU A 1 138 ? 20.75700 26.55900  55.85000 1.000 64.25745  ? 138 GLU A HG3  1 
ATOM   1501 N  N    . PHE A 1 139 ? 20.58900 26.20200  51.03800 1.000 33.87927  ? 139 PHE A N    1 
ATOM   1502 C  CA   . PHE A 1 139 ? 20.35200 25.44300  49.81400 1.000 31.67128  ? 139 PHE A CA   1 
ATOM   1503 C  C    . PHE A 1 139 ? 21.46300 25.65100  48.79100 1.000 29.93569  ? 139 PHE A C    1 
ATOM   1504 O  O    . PHE A 1 139 ? 21.86300 26.78400  48.51000 1.000 25.51571  ? 139 PHE A O    1 
ATOM   1505 C  CB   . PHE A 1 139 ? 19.00200 25.87300  49.23700 1.000 35.64323  ? 139 PHE A CB   1 
ATOM   1506 C  CG   . PHE A 1 139 ? 18.64400 25.21700  47.93800 1.000 28.04767  ? 139 PHE A CG   1 
ATOM   1507 C  CD1  . PHE A 1 139 ? 18.76800 23.84800  47.76900 1.000 28.48230  ? 139 PHE A CD1  1 
ATOM   1508 C  CD2  . PHE A 1 139 ? 18.16500 25.97800  46.88400 1.000 27.75319  ? 139 PHE A CD2  1 
ATOM   1509 C  CE1  . PHE A 1 139 ? 18.42700 23.25400  46.56300 1.000 30.47628  ? 139 PHE A CE1  1 
ATOM   1510 C  CE2  . PHE A 1 139 ? 17.82300 25.39200  45.68200 1.000 29.05452  ? 139 PHE A CE2  1 
ATOM   1511 C  CZ   . PHE A 1 139 ? 17.95300 24.02800  45.52100 1.000 27.96425  ? 139 PHE A CZ   1 
ATOM   1512 H  H    . PHE A 1 139 ? 19.94900 26.74100  51.23500 1.000 40.59489  ? 139 PHE A H    1 
ATOM   1513 H  HA   . PHE A 1 139 ? 20.33800 24.49500  50.01700 1.000 37.94530  ? 139 PHE A HA   1 
ATOM   1514 H  HB2  . PHE A 1 139 ? 18.30700 25.65300  49.87700 1.000 42.71164  ? 139 PHE A HB2  1 
ATOM   1515 H  HB3  . PHE A 1 139 ? 19.02100 26.83100  49.08500 1.000 42.71164  ? 139 PHE A HB3  1 
ATOM   1516 H  HD1  . PHE A 1 139 ? 19.08300 23.32300  48.46900 1.000 34.11852  ? 139 PHE A HD1  1 
ATOM   1517 H  HD2  . PHE A 1 139 ? 18.07200 26.89800  46.98700 1.000 33.24359  ? 139 PHE A HD2  1 
ATOM   1518 H  HE1  . PHE A 1 139 ? 18.51700 22.33400  46.45500 1.000 36.51130  ? 139 PHE A HE1  1 
ATOM   1519 H  HE2  . PHE A 1 139 ? 17.50500 25.91600  44.98200 1.000 34.80518  ? 139 PHE A HE2  1 
ATOM   1520 H  HZ   . PHE A 1 139 ? 17.72200 23.63000  44.71300 1.000 33.49687  ? 139 PHE A HZ   1 
ATOM   1521 N  N    . GLN A 1 140 ? 21.96400 24.54400  48.22500 1.000 29.07416  ? 140 GLN A N    1 
ATOM   1522 C  CA   . GLN A 1 140 ? 22.87200 24.64100  47.08800 1.000 36.63966  ? 140 GLN A CA   1 
ATOM   1523 C  C    . GLN A 1 140 ? 22.54900 23.65500  45.96700 1.000 32.79426  ? 140 GLN A C    1 
ATOM   1524 O  O    . GLN A 1 140 ? 22.50800 24.04900  44.80200 1.000 30.04077  ? 140 GLN A O    1 
ATOM   1525 C  CB   . GLN A 1 140 ? 24.33000 24.41900  47.50900 1.000 34.42810  ? 140 GLN A CB   1 
ATOM   1526 C  CG   . GLN A 1 140 ? 24.78300 25.16500  48.73800 1.000 42.22532  ? 140 GLN A CG   1 
ATOM   1527 C  CD   . GLN A 1 140 ? 26.27400 25.44300  48.69800 1.000 51.12738  ? 140 GLN A CD   1 
ATOM   1528 O  OE1  . GLN A 1 140 ? 26.73400 26.28700  47.92900 1.000 41.99588  ? 140 GLN A OE1  1 
ATOM   1529 N  NE2  . GLN A 1 140 ? 27.03900 24.71900  49.50800 1.000 60.00144  ? 140 GLN A NE2  1 
ATOM   1530 H  H    . GLN A 1 140 ? 21.79200 23.74100  48.48200 1.000 34.82875  ? 140 GLN A H    1 
ATOM   1531 H  HA   . GLN A 1 140 ? 22.76200 25.54100  46.74400 1.000 43.90735  ? 140 GLN A HA   1 
ATOM   1532 H  HB2  . GLN A 1 140 ? 24.45400 23.47300  47.68500 1.000 41.25348  ? 140 GLN A HB2  1 
ATOM   1533 H  HB3  . GLN A 1 140 ? 24.90200 24.69800  46.77700 1.000 41.25348  ? 140 GLN A HB3  1 
ATOM   1534 H  HG2  . GLN A 1 140 ? 24.31500 26.01300  48.79000 1.000 50.61014  ? 140 GLN A HG2  1 
ATOM   1535 H  HG3  . GLN A 1 140 ? 24.59200 24.63200  49.52600 1.000 50.61014  ? 140 GLN A HG3  1 
ATOM   1536 H  HE21 . GLN A 1 140 ? 26.68300 24.12700  50.02100 1.000 71.94149  ? 140 GLN A HE21 1 
ATOM   1537 H  HE22 . GLN A 1 140 ? 27.89000 24.84200  49.52000 1.000 71.94149  ? 140 GLN A HE22 1 
ATOM   1538 N  N    . ASP A 1 141 ? 22.33100 22.38200  46.28600 1.000 27.39828  ? 141 ASP A N    1 
ATOM   1539 C  CA   . ASP A 1 141 ? 22.29700 21.34200  45.27000 1.000 27.34113  ? 141 ASP A CA   1 
ATOM   1540 C  C    . ASP A 1 141 ? 20.94300 20.65000  45.21900 1.000 28.91658  ? 141 ASP A C    1 
ATOM   1541 O  O    . ASP A 1 141 ? 20.25200 20.50700  46.23300 1.000 29.93516  ? 141 ASP A O    1 
ATOM   1542 C  CB   . ASP A 1 141 ? 23.39600 20.30300  45.51600 1.000 30.78916  ? 141 ASP A CB   1 
ATOM   1543 C  CG   . ASP A 1 141 ? 24.75900 20.93600  45.72200 1.000 27.47634  ? 141 ASP A CG   1 
ATOM   1544 O  OD1  . ASP A 1 141 ? 25.17400 21.74400  44.86700 1.000 36.46963  ? 141 ASP A OD1  1 
ATOM   1545 O  OD2  . ASP A 1 141 ? 25.41600 20.62500  46.73800 1.000 33.84801  ? 141 ASP A OD2  1 
ATOM   1546 H  H    . ASP A 1 141 ? 22.20200 22.09900  47.08800 1.000 32.81770  ? 141 ASP A H    1 
ATOM   1547 H  HA   . ASP A 1 141 ? 22.43500 21.75500  44.40400 1.000 32.74912  ? 141 ASP A HA   1 
ATOM   1548 H  HB2  . ASP A 1 141 ? 23.17800 19.79200  46.31100 1.000 36.88675  ? 141 ASP A HB2  1 
ATOM   1549 H  HB3  . ASP A 1 141 ? 23.45200 19.71300  44.74800 1.000 36.88675  ? 141 ASP A HB3  1 
ATOM   1550 N  N    . VAL A 1 142 ? 20.58000 20.22700  44.00800 1.000 29.03593  ? 142 VAL A N    1 
ATOM   1551 C  CA   . VAL A 1 142 ? 19.38500 19.44200  43.73600 1.000 26.53602  ? 142 VAL A CA   1 
ATOM   1552 C  C    . VAL A 1 142 ? 19.82600 18.10100  43.17000 1.000 27.93860  ? 142 VAL A C    1 
ATOM   1553 O  O    . VAL A 1 142 ? 20.71600 18.04400  42.31300 1.000 29.24040  ? 142 VAL A O    1 
ATOM   1554 C  CB   . VAL A 1 142 ? 18.44300 20.15700  42.74300 1.000 27.32704  ? 142 VAL A CB   1 
ATOM   1555 C  CG1  . VAL A 1 142 ? 17.19700 19.31700  42.48700 1.000 34.53295  ? 142 VAL A CG1  1 
ATOM   1556 C  CG2  . VAL A 1 142 ? 18.06900 21.53700  43.25700 1.000 31.86747  ? 142 VAL A CG2  1 
ATOM   1557 H  H    . VAL A 1 142 ? 21.03400 20.39300  43.29700 1.000 34.78288  ? 142 VAL A H    1 
ATOM   1558 H  HA   . VAL A 1 142 ? 18.89900 19.29700  44.56400 1.000 31.78298  ? 142 VAL A HA   1 
ATOM   1559 H  HB   . VAL A 1 142 ? 18.90800 20.26800  41.89900 1.000 32.73221  ? 142 VAL A HB   1 
ATOM   1560 H  HG11 . VAL A 1 142 ? 16.55200 19.85000  41.99700 1.000 41.37931  ? 142 VAL A HG11 1 
ATOM   1561 H  HG12 . VAL A 1 142 ? 17.44400 18.53600  41.96800 1.000 41.37931  ? 142 VAL A HG12 1 
ATOM   1562 H  HG13 . VAL A 1 142 ? 16.82100 19.04300  43.33800 1.000 41.37931  ? 142 VAL A HG13 1 
ATOM   1563 H  HG21 . VAL A 1 142 ? 17.33900 21.88700  42.72200 1.000 38.18073  ? 142 VAL A HG21 1 
ATOM   1564 H  HG22 . VAL A 1 142 ? 17.79300 21.46500  44.18500 1.000 38.18073  ? 142 VAL A HG22 1 
ATOM   1565 H  HG23 . VAL A 1 142 ? 18.84000 22.12100  43.18600 1.000 38.18073  ? 142 VAL A HG23 1 
ATOM   1566 N  N    . TYR A 1 143 ? 19.20300 17.02500  43.64200 1.000 23.87702  ? 143 TYR A N    1 
ATOM   1567 C  CA   . TYR A 1 143 ? 19.48000 15.68400  43.14200 1.000 23.27531  ? 143 TYR A CA   1 
ATOM   1568 C  C    . TYR A 1 143 ? 18.22100 15.11500  42.50700 1.000 22.50378  ? 143 TYR A C    1 
ATOM   1569 O  O    . TYR A 1 143 ? 17.15800 15.09100  43.13600 1.000 26.61497  ? 143 TYR A O    1 
ATOM   1570 C  CB   . TYR A 1 143 ? 19.97600 14.76700  44.25800 1.000 22.85196  ? 143 TYR A CB   1 
ATOM   1571 C  CG   . TYR A 1 143 ? 21.34500 15.13800  44.77300 1.000 25.18662  ? 143 TYR A CG   1 
ATOM   1572 C  CD1  . TYR A 1 143 ? 21.50100 16.14300  45.72000 1.000 25.49424  ? 143 TYR A CD1  1 
ATOM   1573 C  CD2  . TYR A 1 143 ? 22.48100 14.49500  44.30700 1.000 26.00292  ? 143 TYR A CD2  1 
ATOM   1574 C  CE1  . TYR A 1 143 ? 22.75100 16.48900  46.19200 1.000 27.19171  ? 143 TYR A CE1  1 
ATOM   1575 C  CE2  . TYR A 1 143 ? 23.73600 14.83400  44.77500 1.000 30.17377  ? 143 TYR A CE2  1 
ATOM   1576 C  CZ   . TYR A 1 143 ? 23.86500 15.83200  45.71800 1.000 30.93532  ? 143 TYR A CZ   1 
ATOM   1577 O  OH   . TYR A 1 143 ? 25.11100 16.17400  46.18900 1.000 26.05762  ? 143 TYR A OH   1 
ATOM   1578 H  H    . TYR A 1 143 ? 18.60700 17.04800  44.26100 1.000 28.59219  ? 143 TYR A H    1 
ATOM   1579 H  HA   . TYR A 1 143 ? 20.17000 15.73000  42.46200 1.000 27.87013  ? 143 TYR A HA   1 
ATOM   1580 H  HB2  . TYR A 1 143 ? 19.35500 14.81300  45.00200 1.000 27.36212  ? 143 TYR A HB2  1 
ATOM   1581 H  HB3  . TYR A 1 143 ? 20.02200 13.85800  43.92000 1.000 27.36212  ? 143 TYR A HB3  1 
ATOM   1582 H  HD1  . TYR A 1 143 ? 20.75100 16.58900  46.04100 1.000 30.53285  ? 143 TYR A HD1  1 
ATOM   1583 H  HD2  . TYR A 1 143 ? 22.39800 13.82400  43.66800 1.000 31.14326  ? 143 TYR A HD2  1 
ATOM   1584 H  HE1  . TYR A 1 143 ? 22.84000 17.16200  46.82800 1.000 32.56982  ? 143 TYR A HE1  1 
ATOM   1585 H  HE2  . TYR A 1 143 ? 24.49000 14.39300  44.45600 1.000 36.14828  ? 143 TYR A HE2  1 
ATOM   1586 H  HH   . TYR A 1 143 ? 25.03800 16.71400  46.82900 1.000 31.20890  ? 143 TYR A HH   1 
ATOM   1587 N  N    . LEU A 1 144 ? 18.34800 14.66800  41.26300 1.000 25.13164  ? 144 LEU A N    1 
ATOM   1588 C  CA   . LEU A 1 144 ? 17.25700 14.07100  40.50900 1.000 21.32646  ? 144 LEU A CA   1 
ATOM   1589 C  C    . LEU A 1 144 ? 17.53300 12.58500  40.33200 1.000 19.05142  ? 144 LEU A C    1 
ATOM   1590 O  O    . LEU A 1 144 ? 18.66700 12.19100  40.04600 1.000 24.67287  ? 144 LEU A O    1 
ATOM   1591 C  CB   . LEU A 1 144 ? 17.10500 14.73700  39.13900 1.000 20.37541  ? 144 LEU A CB   1 
ATOM   1592 C  CG   . LEU A 1 144 ? 17.06200 16.26500  39.11600 1.000 23.51900  ? 144 LEU A CG   1 
ATOM   1593 C  CD1  . LEU A 1 144 ? 17.05700 16.75900  37.67800 1.000 28.81016  ? 144 LEU A CD1  1 
ATOM   1594 C  CD2  . LEU A 1 144 ? 15.84600 16.77800  39.86100 1.000 27.42133  ? 144 LEU A CD2  1 
ATOM   1595 H  H    . LEU A 1 144 ? 19.08400 14.70100  40.81900 1.000 30.09773  ? 144 LEU A H    1 
ATOM   1596 H  HA   . LEU A 1 144 ? 16.42100 14.18100  40.99000 1.000 25.53151  ? 144 LEU A HA   1 
ATOM   1597 H  HB2  . LEU A 1 144 ? 17.85800 14.46600  38.59000 1.000 24.39025  ? 144 LEU A HB2  1 
ATOM   1598 H  HB3  . LEU A 1 144 ? 16.27700 14.42300  38.74400 1.000 24.39025  ? 144 LEU A HB3  1 
ATOM   1599 H  HG   . LEU A 1 144 ? 17.84900 16.61500  39.56100 1.000 28.16257  ? 144 LEU A HG   1 
ATOM   1600 H  HD11 . LEU A 1 144 ? 17.10900 17.72800  37.67700 1.000 34.51195  ? 144 LEU A HD11 1 
ATOM   1601 H  HD12 . LEU A 1 144 ? 17.82300 16.38600  37.21300 1.000 34.51195  ? 144 LEU A HD12 1 
ATOM   1602 H  HD13 . LEU A 1 144 ? 16.23700 16.47100  37.24800 1.000 34.51195  ? 144 LEU A HD13 1 
ATOM   1603 H  HD21 . LEU A 1 144 ? 15.80500 17.74300  39.77100 1.000 32.84536  ? 144 LEU A HD21 1 
ATOM   1604 H  HD22 . LEU A 1 144 ? 15.04900 16.37700  39.48000 1.000 32.84536  ? 144 LEU A HD22 1 
ATOM   1605 H  HD23 . LEU A 1 144 ? 15.92300 16.53600  40.79700 1.000 32.84536  ? 144 LEU A HD23 1 
ATOM   1606 N  N    . VAL A 1 145 ? 16.49500 11.76700  40.48800 1.000 23.81855  ? 145 VAL A N    1 
ATOM   1607 C  CA   . VAL A 1 145 ? 16.62400 10.31400  40.44600 1.000 20.80273  ? 145 VAL A CA   1 
ATOM   1608 C  C    . VAL A 1 145 ? 15.63000 9.76100   39.43800 1.000 20.02722  ? 145 VAL A C    1 
ATOM   1609 O  O    . VAL A 1 145 ? 14.44500 10.11000  39.47700 1.000 23.07485  ? 145 VAL A O    1 
ATOM   1610 C  CB   . VAL A 1 145 ? 16.37700 9.68300   41.83300 1.000 22.30750  ? 145 VAL A CB   1 
ATOM   1611 C  CG1  . VAL A 1 145 ? 16.69000 8.19300   41.80100 1.000 22.96857  ? 145 VAL A CG1  1 
ATOM   1612 C  CG2  . VAL A 1 145 ? 17.19900 10.39100  42.89500 1.000 23.38331  ? 145 VAL A CG2  1 
ATOM   1613 H  H    . VAL A 1 145 ? 15.69000 12.03700  40.62300 1.000 28.52202  ? 145 VAL A H    1 
ATOM   1614 H  HA   . VAL A 1 145 ? 17.51800 10.08600  40.14800 1.000 24.90303  ? 145 VAL A HA   1 
ATOM   1615 H  HB   . VAL A 1 145 ? 15.44100 9.78700   42.06500 1.000 26.70876  ? 145 VAL A HB   1 
ATOM   1616 H  HG11 . VAL A 1 145 ? 16.58000 7.82900   42.69400 1.000 27.50205  ? 145 VAL A HG11 1 
ATOM   1617 H  HG12 . VAL A 1 145 ? 16.08000 7.75500   41.18700 1.000 27.50205  ? 145 VAL A HG12 1 
ATOM   1618 H  HG13 . VAL A 1 145 ? 17.60500 8.06900   41.50400 1.000 27.50205  ? 145 VAL A HG13 1 
ATOM   1619 H  HG21 . VAL A 1 145 ? 17.17100 9.87200   43.71400 1.000 27.99973  ? 145 VAL A HG21 1 
ATOM   1620 H  HG22 . VAL A 1 145 ? 18.11500 10.47100  42.58500 1.000 27.99973  ? 145 VAL A HG22 1 
ATOM   1621 H  HG23 . VAL A 1 145 ? 16.82400 11.27300  43.04900 1.000 27.99973  ? 145 VAL A HG23 1 
ATOM   1622 N  N    . MET A 1 146 ? 16.10400 8.89000   38.54400 1.000 22.32535  ? 146 MET A N    1 
ATOM   1623 C  CA   . MET A 1 146 ? 15.22100 8.14700   37.65600 1.000 23.83807  ? 146 MET A CA   1 
ATOM   1624 C  C    . MET A 1 146 ? 15.70000 6.71100   37.52700 1.000 18.47824  ? 146 MET A C    1 
ATOM   1625 O  O    . MET A 1 146 ? 16.78800 6.34400   37.98200 1.000 23.05960  ? 146 MET A O    1 
ATOM   1626 C  CB   . MET A 1 146 ? 15.15100 8.73200   36.23600 1.000 21.57846  ? 146 MET A CB   1 
ATOM   1627 C  CG   . MET A 1 146 ? 16.50500 8.88400   35.56100 1.000 23.79407  ? 146 MET A CG   1 
ATOM   1628 S  SD   . MET A 1 146 ? 16.38500 9.38100   33.82000 1.000 29.11245  ? 146 MET A SD   1 
ATOM   1629 C  CE   . MET A 1 146 ? 15.46000 8.02000   33.13000 1.000 25.62974  ? 146 MET A CE   1 
ATOM   1630 H  H    . MET A 1 146 ? 16.93900 8.71400   38.43600 1.000 26.73018  ? 146 MET A H    1 
ATOM   1631 H  HA   . MET A 1 146 ? 14.34200 8.18800   38.06400 1.000 28.54545  ? 146 MET A HA   1 
ATOM   1632 H  HB2  . MET A 1 146 ? 14.61000 8.14500   35.68500 1.000 25.83391  ? 146 MET A HB2  1 
ATOM   1633 H  HB3  . MET A 1 146 ? 14.74400 9.61200   36.28300 1.000 25.83391  ? 146 MET A HB3  1 
ATOM   1634 H  HG2  . MET A 1 146 ? 17.01600 9.56200   36.03000 1.000 28.49265  ? 146 MET A HG2  1 
ATOM   1635 H  HG3  . MET A 1 146 ? 16.97100 8.03400   35.59600 1.000 28.49265  ? 146 MET A HG3  1 
ATOM   1636 H  HE1  . MET A 1 146 ? 15.35500 8.16100   32.17600 1.000 30.69545  ? 146 MET A HE1  1 
ATOM   1637 H  HE2  . MET A 1 146 ? 15.94400 7.19500   33.29200 1.000 30.69545  ? 146 MET A HE2  1 
ATOM   1638 H  HE3  . MET A 1 146 ? 14.58900 7.98200   33.55600 1.000 30.69545  ? 146 MET A HE3  1 
ATOM   1639 N  N    . GLU A 1 147 ? 14.87500 5.91000   36.85500 1.000 28.35850  ? 147 GLU A N    1 
ATOM   1640 C  CA   . GLU A 1 147 ? 15.25700 4.56400   36.44300 1.000 27.31831  ? 147 GLU A CA   1 
ATOM   1641 C  C    . GLU A 1 147 ? 16.61900 4.56600   35.76000 1.000 27.15919  ? 147 GLU A C    1 
ATOM   1642 O  O    . GLU A 1 147 ? 16.92000 5.43800   34.94100 1.000 25.18697  ? 147 GLU A O    1 
ATOM   1643 C  CB   . GLU A 1 147 ? 14.19400 4.01400   35.48400 1.000 32.21717  ? 147 GLU A CB   1 
ATOM   1644 C  CG   . GLU A 1 147 ? 14.50800 2.66200   34.87500 1.000 52.87087  ? 147 GLU A CG   1 
ATOM   1645 C  CD   . GLU A 1 147 ? 13.32700 2.08500   34.11200 1.000 53.72553  ? 147 GLU A CD   1 
ATOM   1646 O  OE1  . GLU A 1 147 ? 12.37100 2.84200   33.83400 1.000 42.69995  ? 147 GLU A OE1  1 
ATOM   1647 O  OE2  . GLU A 1 147 ? 13.35700 0.88100   33.78600 1.000 64.36549  ? 147 GLU A OE2  1 
ATOM   1648 H  H    . GLU A 1 147 ? 14.07500 6.12600   36.62300 1.000 33.96996  ? 147 GLU A H    1 
ATOM   1649 H  HA   . GLU A 1 147 ? 15.31700 3.98900   37.22100 1.000 32.72174  ? 147 GLU A HA   1 
ATOM   1650 H  HB2  . GLU A 1 147 ? 13.36000 3.92500   35.97200 1.000 38.60036  ? 147 GLU A HB2  1 
ATOM   1651 H  HB3  . GLU A 1 147 ? 14.08600 4.64300   34.75400 1.000 38.60036  ? 147 GLU A HB3  1 
ATOM   1652 H  HG2  . GLU A 1 147 ? 15.25000 2.75600   34.25800 1.000 63.38480  ? 147 GLU A HG2  1 
ATOM   1653 H  HG3  . GLU A 1 147 ? 14.74300 2.04100   35.58300 1.000 63.38480  ? 147 GLU A HG3  1 
ATOM   1654 N  N    . LEU A 1 148 ? 17.43900 3.57000   36.08900 1.000 22.31878  ? 148 LEU A N    1 
ATOM   1655 C  CA   . LEU A 1 148 ? 18.72400 3.38600   35.42600 1.000 24.39743  ? 148 LEU A CA   1 
ATOM   1656 C  C    . LEU A 1 148 ? 18.50600 2.68400   34.09000 1.000 29.84510  ? 148 LEU A C    1 
ATOM   1657 O  O    . LEU A 1 148 ? 17.93100 1.59400   34.04000 1.000 28.61283  ? 148 LEU A O    1 
ATOM   1658 C  CB   . LEU A 1 148 ? 19.68100 2.57900   36.30000 1.000 26.68115  ? 148 LEU A CB   1 
ATOM   1659 C  CG   . LEU A 1 148 ? 21.08200 2.37800   35.70900 1.000 30.01470  ? 148 LEU A CG   1 
ATOM   1660 C  CD1  . LEU A 1 148 ? 21.82900 3.70000   35.61000 1.000 29.63959  ? 148 LEU A CD1  1 
ATOM   1661 C  CD2  . LEU A 1 148 ? 21.88100 1.36500   36.52200 1.000 26.09143  ? 148 LEU A CD2  1 
ATOM   1662 H  H    . LEU A 1 148 ? 17.27100 2.98500   36.69700 1.000 26.72229  ? 148 LEU A H    1 
ATOM   1663 H  HA   . LEU A 1 148 ? 19.12400 4.25600   35.26600 1.000 29.21668  ? 148 LEU A HA   1 
ATOM   1664 H  HB2  . LEU A 1 148 ? 19.78500 3.03900   37.14800 1.000 31.95714  ? 148 LEU A HB2  1 
ATOM   1665 H  HB3  . LEU A 1 148 ? 19.29600 1.70000   36.44500 1.000 31.95714  ? 148 LEU A HB3  1 
ATOM   1666 H  HG   . LEU A 1 148 ? 20.98500 2.02600   34.81000 1.000 35.95740  ? 148 LEU A HG   1 
ATOM   1667 H  HD11 . LEU A 1 148 ? 22.76400 3.52100   35.42300 1.000 35.50727  ? 148 LEU A HD11 1 
ATOM   1668 H  HD12 . LEU A 1 148 ? 21.44300 4.22800   34.89400 1.000 35.50727  ? 148 LEU A HD12 1 
ATOM   1669 H  HD13 . LEU A 1 148 ? 21.74500 4.17400   36.45300 1.000 35.50727  ? 148 LEU A HD13 1 
ATOM   1670 H  HD21 . LEU A 1 148 ? 22.75600 1.25600   36.11700 1.000 31.24948  ? 148 LEU A HD21 1 
ATOM   1671 H  HD22 . LEU A 1 148 ? 21.97500 1.69300   37.43000 1.000 31.24948  ? 148 LEU A HD22 1 
ATOM   1672 H  HD23 . LEU A 1 148 ? 21.40900 0.51800   36.52300 1.000 31.24948  ? 148 LEU A HD23 1 
ATOM   1673 N  N    . MET A 1 149 ? 18.96900 3.30300   33.01300 1.000 25.80838  ? 149 MET A N    1 
ATOM   1674 C  CA   . MET A 1 149 ? 18.85000 2.72700   31.68500 1.000 26.91579  ? 149 MET A CA   1 
ATOM   1675 C  C    . MET A 1 149 ? 20.13100 1.95000   31.38600 1.000 29.52150  ? 149 MET A C    1 
ATOM   1676 O  O    . MET A 1 149 ? 20.93900 1.69300   32.27900 1.000 28.38314  ? 149 MET A O    1 
ATOM   1677 C  CB   . MET A 1 149 ? 18.57400 3.82900   30.66600 1.000 24.72549  ? 149 MET A CB   1 
ATOM   1678 C  CG   . MET A 1 149 ? 17.25600 4.57300   30.86200 1.000 27.10619  ? 149 MET A CG   1 
ATOM   1679 S  SD   . MET A 1 149 ? 15.79000 3.54100   30.94500 1.000 30.98666  ? 149 MET A SD   1 
ATOM   1680 C  CE   . MET A 1 149 ? 14.98700 3.98500   29.40300 1.000 31.77309  ? 149 MET A CE   1 
ATOM   1681 H  H    . MET A 1 149 ? 19.36100 4.06800   33.02700 1.000 30.90982  ? 149 MET A H    1 
ATOM   1682 H  HA   . MET A 1 149 ? 18.09500 2.11800   31.66100 1.000 32.23871  ? 149 MET A HA   1 
ATOM   1683 H  HB2  . MET A 1 149 ? 19.28800 4.48400   30.72000 1.000 29.61034  ? 149 MET A HB2  1 
ATOM   1684 H  HB3  . MET A 1 149 ? 18.55500 3.43200   29.78100 1.000 29.61034  ? 149 MET A HB3  1 
ATOM   1685 H  HG2  . MET A 1 149 ? 17.30600 5.06900   31.69300 1.000 32.46718  ? 149 MET A HG2  1 
ATOM   1686 H  HG3  . MET A 1 149 ? 17.13600 5.18300   30.11700 1.000 32.46718  ? 149 MET A HG3  1 
ATOM   1687 H  HE1  . MET A 1 149 ? 14.16100 3.48200   29.32100 1.000 38.06747  ? 149 MET A HE1  1 
ATOM   1688 H  HE2  . MET A 1 149 ? 14.79600 4.93600   29.40900 1.000 38.06747  ? 149 MET A HE2  1 
ATOM   1689 H  HE3  . MET A 1 149 ? 15.57900 3.77100   28.66500 1.000 38.06747  ? 149 MET A HE3  1 
ATOM   1690 N  N    . ASP A 1 150 ? 20.35300 1.59100   30.11400 1.000 28.84468  ? 150 ASP A N    1 
ATOM   1691 C  CA   . ASP A 1 150 ? 21.50500 0.78100   29.74300 1.000 25.68902  ? 150 ASP A CA   1 
ATOM   1692 C  C    . ASP A 1 150 ? 22.51400 1.49200   28.85500 1.000 30.00838  ? 150 ASP A C    1 
ATOM   1693 O  O    . ASP A 1 150 ? 23.68700 1.11200   28.86900 1.000 31.35259  ? 150 ASP A O    1 
ATOM   1694 C  CB   . ASP A 1 150 ? 21.04800 -0.50200  29.03200 1.000 26.81017  ? 150 ASP A CB   1 
ATOM   1695 C  CG   . ASP A 1 150 ? 20.25100 -1.41900  29.94300 1.000 31.27172  ? 150 ASP A CG   1 
ATOM   1696 O  OD1  . ASP A 1 150 ? 20.67800 -1.62000  31.09900 1.000 30.83981  ? 150 ASP A OD1  1 
ATOM   1697 O  OD2  . ASP A 1 150 ? 19.20400 -1.94200  29.50600 1.000 39.15697  ? 150 ASP A OD2  1 
ATOM   1698 H  H    . ASP A 1 150 ? 19.84800 1.80800   29.45300 1.000 34.55337  ? 150 ASP A H    1 
ATOM   1699 H  HA   . ASP A 1 150 ? 21.96800 0.52700   30.55700 1.000 30.76659  ? 150 ASP A HA   1 
ATOM   1700 H  HB2  . ASP A 1 150 ? 20.48600 -0.26400  28.27800 1.000 32.11197  ? 150 ASP A HB2  1 
ATOM   1701 H  HB3  . ASP A 1 150 ? 21.82800 -0.98900  28.72300 1.000 32.11197  ? 150 ASP A HB3  1 
ATOM   1702 N  N    . ALA A 1 151 ? 22.10600 2.50800   28.09900 1.000 27.66915  ? 151 ALA A N    1 
ATOM   1703 C  CA   . ALA A 1 151 ? 23.02800 3.13000   27.15900 1.000 29.88902  ? 151 ALA A CA   1 
ATOM   1704 C  C    . ALA A 1 151 ? 22.45100 4.44800   26.67200 1.000 22.47564  ? 151 ALA A C    1 
ATOM   1705 O  O    . ALA A 1 151 ? 21.23900 4.67200   26.71500 1.000 23.53800  ? 151 ALA A O    1 
ATOM   1706 C  CB   . ALA A 1 151 ? 23.31200 2.21000   25.96500 1.000 30.75459  ? 151 ALA A CB   1 
ATOM   1707 H  H    . ALA A 1 151 ? 21.31600 2.84700   28.11400 1.000 33.14274  ? 151 ALA A H    1 
ATOM   1708 H  HA   . ALA A 1 151 ? 23.85800 3.32300   27.62100 1.000 35.80659  ? 151 ALA A HA   1 
ATOM   1709 H  HB1  . ALA A 1 151 ? 23.92100 2.65900   25.35800 1.000 36.84527  ? 151 ALA A HB1  1 
ATOM   1710 H  HB2  . ALA A 1 151 ? 23.71300 1.38800   26.28900 1.000 36.84527  ? 151 ALA A HB2  1 
ATOM   1711 H  HB3  . ALA A 1 151 ? 22.47700 2.01400   25.51200 1.000 36.84527  ? 151 ALA A HB3  1 
ATOM   1712 N  N    . ASN A 1 152 ? 23.34900 5.31100   26.20700 1.000 26.55330  ? 152 ASN A N    1 
ATOM   1713 C  CA   . ASN A 1 152 ? 22.98400 6.53200   25.50700 1.000 32.94167  ? 152 ASN A CA   1 
ATOM   1714 C  C    . ASN A 1 152 ? 22.71100 6.22600   24.03600 1.000 22.97162  ? 152 ASN A C    1 
ATOM   1715 O  O    . ASN A 1 152 ? 23.27500 5.29100   23.46400 1.000 22.01582  ? 152 ASN A O    1 
ATOM   1716 C  CB   . ASN A 1 152 ? 24.11500 7.55400   25.63200 1.000 31.15819  ? 152 ASN A CB   1 
ATOM   1717 C  CG   . ASN A 1 152 ? 23.66000 8.96400   25.36700 1.000 40.07062  ? 152 ASN A CG   1 
ATOM   1718 O  OD1  . ASN A 1 152 ? 23.76100 9.45600   24.24400 1.000 48.87311  ? 152 ASN A OD1  1 
ATOM   1719 N  ND2  . ASN A 1 152 ? 23.17600 9.63800   26.40700 1.000 51.45829  ? 152 ASN A ND2  1 
ATOM   1720 H  H    . ASN A 1 152 ? 24.19900 5.20800   26.28700 1.000 31.80372  ? 152 ASN A H    1 
ATOM   1721 H  HA   . ASN A 1 152 ? 22.18100 6.91800   25.89000 1.000 39.46976  ? 152 ASN A HA   1 
ATOM   1722 H  HB2  . ASN A 1 152 ? 24.47300 7.51900   26.53300 1.000 37.32959  ? 152 ASN A HB2  1 
ATOM   1723 H  HB3  . ASN A 1 152 ? 24.80900 7.33800   24.99000 1.000 37.32959  ? 152 ASN A HB3  1 
ATOM   1724 H  HD21 . ASN A 1 152 ? 23.13500 9.26400   27.18000 1.000 61.68971  ? 152 ASN A HD21 1 
ATOM   1725 H  HD22 . ASN A 1 152 ? 22.90300 10.44700  26.30500 1.000 61.68971  ? 152 ASN A HD22 1 
ATOM   1726 N  N    . LEU A 1 153 ? 21.83500 7.02600   23.42000 1.000 24.40246  ? 153 LEU A N    1 
ATOM   1727 C  CA   . LEU A 1 153 ? 21.50400 6.78000   22.01700 1.000 25.65811  ? 153 LEU A CA   1 
ATOM   1728 C  C    . LEU A 1 153 ? 22.70700 7.00100   21.10800 1.000 26.80714  ? 153 LEU A C    1 
ATOM   1729 O  O    . LEU A 1 153 ? 22.77300 6.41100   20.02100 1.000 32.19057  ? 153 LEU A O    1 
ATOM   1730 C  CB   . LEU A 1 153 ? 20.33300 7.65800   21.57800 1.000 19.45578  ? 153 LEU A CB   1 
ATOM   1731 C  CG   . LEU A 1 153 ? 19.72400 7.33000   20.21000 1.000 24.95874  ? 153 LEU A CG   1 
ATOM   1732 C  CD1  . LEU A 1 153 ? 19.05300 5.95600   20.19200 1.000 22.30902  ? 153 LEU A CD1  1 
ATOM   1733 C  CD2  . LEU A 1 153 ? 18.72200 8.39700   19.81700 1.000 23.06469  ? 153 LEU A CD2  1 
ATOM   1734 H  H    . LEU A 1 153 ? 21.43300 7.69400   23.78100 1.000 29.22271  ? 153 LEU A H    1 
ATOM   1735 H  HA   . LEU A 1 153 ? 21.22400 5.85500   21.92600 1.000 30.72949  ? 153 LEU A HA   1 
ATOM   1736 H  HB2  . LEU A 1 153 ? 19.62500 7.57000   22.23600 1.000 23.28669  ? 153 LEU A HB2  1 
ATOM   1737 H  HB3  . LEU A 1 153 ? 20.64100 8.57700   21.54300 1.000 23.28669  ? 153 LEU A HB3  1 
ATOM   1738 H  HG   . LEU A 1 153 ? 20.44400 7.30800   19.56000 1.000 29.89025  ? 153 LEU A HG   1 
ATOM   1739 H  HD11 . LEU A 1 153 ? 18.61400 5.83000   19.33700 1.000 26.71059  ? 153 LEU A HD11 1 
ATOM   1740 H  HD12 . LEU A 1 153 ? 19.72900 5.27200   20.32100 1.000 26.71059  ? 153 LEU A HD12 1 
ATOM   1741 H  HD13 . LEU A 1 153 ? 18.40000 5.91300   20.90900 1.000 26.71059  ? 153 LEU A HD13 1 
ATOM   1742 H  HD21 . LEU A 1 153 ? 18.43200 8.23800   18.90500 1.000 27.61739  ? 153 LEU A HD21 1 
ATOM   1743 H  HD22 . LEU A 1 153 ? 17.96200 8.35200   20.41800 1.000 27.61739  ? 153 LEU A HD22 1 
ATOM   1744 H  HD23 . LEU A 1 153 ? 19.14500 9.26700   19.88300 1.000 27.61739  ? 153 LEU A HD23 1 
ATOM   1745 N  N    . CYS A 1 154 ? 23.66500 7.83300   21.52400 1.000 20.65437  ? 154 CYS A N    1 
ATOM   1746 C  CA   . CYS A 1 154 ? 24.90400 7.95400   20.76000 1.000 31.92353  ? 154 CYS A CA   1 
ATOM   1747 C  C    . CYS A 1 154 ? 25.59000 6.60000   20.63200 1.000 35.60163  ? 154 CYS A C    1 
ATOM   1748 O  O    . CYS A 1 154 ? 26.14500 6.27000   19.57900 1.000 31.16575  ? 154 CYS A O    1 
ATOM   1749 C  CB   . CYS A 1 154 ? 25.84400 8.96100   21.42300 1.000 32.52031  ? 154 CYS A CB   1 
ATOM   1750 S  SG   . CYS A 1 154 ? 25.14200 10.60400  21.65800 1.000 41.93378  ? 154 CYS A SG   1 
ATOM   1751 H  H    . CYS A 1 154 ? 23.62300 8.32500   22.22800 1.000 24.72501  ? 154 CYS A H    1 
ATOM   1752 H  HA   . CYS A 1 154 ? 24.69400 8.28400   19.87200 1.000 38.24800  ? 154 CYS A HA   1 
ATOM   1753 H  HB2  . CYS A 1 154 ? 26.09200 8.62200   22.29700 1.000 38.96413  ? 154 CYS A HB2  1 
ATOM   1754 H  HB3  . CYS A 1 154 ? 26.63400 9.05700   20.86800 1.000 38.96413  ? 154 CYS A HB3  1 
ATOM   1755 H  HG   . CYS A 1 154 ? 25.92900 11.28300  22.25800 1.000 50.26030  ? 154 CYS A HG   1 
ATOM   1756 N  N    . GLN A 1 155 ? 25.55500 5.80400   21.70100 1.000 28.98790  ? 155 GLN A N    1 
ATOM   1757 C  CA   . GLN A 1 155 ? 26.14900 4.47400   21.66900 1.000 30.66887  ? 155 GLN A CA   1 
ATOM   1758 C  C    . GLN A 1 155 ? 25.43100 3.57600   20.67600 1.000 27.49278  ? 155 GLN A C    1 
ATOM   1759 O  O    . GLN A 1 155 ? 26.06900 2.84500   19.90800 1.000 34.07939  ? 155 GLN A O    1 
ATOM   1760 C  CB   . GLN A 1 155 ? 26.09500 3.86100   23.06800 1.000 31.40877  ? 155 GLN A CB   1 
ATOM   1761 C  CG   . GLN A 1 155 ? 27.04900 4.48600   24.06000 1.000 34.90696  ? 155 GLN A CG   1 
ATOM   1762 C  CD   . GLN A 1 155 ? 26.83900 3.94700   25.46300 1.000 57.97013  ? 155 GLN A CD   1 
ATOM   1763 O  OE1  . GLN A 1 155 ? 26.01700 4.46500   26.22000 1.000 37.78410  ? 155 GLN A OE1  1 
ATOM   1764 N  NE2  . GLN A 1 155 ? 27.56400 2.88800   25.80700 1.000 53.88687  ? 155 GLN A NE2  1 
ATOM   1765 H  H    . GLN A 1 155 ? 25.19400 6.01100   22.45400 1.000 34.72524  ? 155 GLN A H    1 
ATOM   1766 H  HA   . GLN A 1 155 ? 27.07700 4.54700   21.39500 1.000 36.74241  ? 155 GLN A HA   1 
ATOM   1767 H  HB2  . GLN A 1 155 ? 25.19600 3.96700   23.41700 1.000 37.63028  ? 155 GLN A HB2  1 
ATOM   1768 H  HB3  . GLN A 1 155 ? 26.31600 2.91900   23.00100 1.000 37.63028  ? 155 GLN A HB3  1 
ATOM   1769 H  HG2  . GLN A 1 155 ? 27.96100 4.29100   23.79400 1.000 41.82811  ? 155 GLN A HG2  1 
ATOM   1770 H  HG3  . GLN A 1 155 ? 26.90700 5.44500   24.07900 1.000 41.82811  ? 155 GLN A HG3  1 
ATOM   1771 H  HE21 . GLN A 1 155 ? 28.11600 2.54500   25.24500 1.000 64.60400  ? 155 GLN A HE21 1 
ATOM   1772 H  HE22 . GLN A 1 155 ? 27.48000 2.54700   26.59200 1.000 64.60400  ? 155 GLN A HE22 1 
ATOM   1773 N  N    . VAL A 1 156 ? 24.09800 3.60900   20.68700 1.000 25.49301  ? 156 VAL A N    1 
ATOM   1774 C  CA   . VAL A 1 156 ? 23.31300 2.76600   19.79000 1.000 32.23737  ? 156 VAL A CA   1 
ATOM   1775 C  C    . VAL A 1 156 ? 23.55700 3.16000   18.34000 1.000 34.26759  ? 156 VAL A C    1 
ATOM   1776 O  O    . VAL A 1 156 ? 23.61200 2.30400   17.44800 1.000 30.42877  ? 156 VAL A O    1 
ATOM   1777 C  CB   . VAL A 1 156 ? 21.82000 2.86200   20.16100 1.000 35.01766  ? 156 VAL A CB   1 
ATOM   1778 C  CG1  . VAL A 1 156 ? 20.99300 1.90300   19.32700 1.000 39.73069  ? 156 VAL A CG1  1 
ATOM   1779 C  CG2  . VAL A 1 156 ? 21.62500 2.59700   21.65000 1.000 26.94534  ? 156 VAL A CG2  1 
ATOM   1780 H  H    . VAL A 1 156 ? 23.62600 4.11000   21.20200 1.000 30.53137  ? 156 VAL A H    1 
ATOM   1781 H  HA   . VAL A 1 156 ? 23.59600 1.84400   19.89700 1.000 38.62461  ? 156 VAL A HA   1 
ATOM   1782 H  HB   . VAL A 1 156 ? 21.50800 3.76000   19.97000 1.000 41.96095  ? 156 VAL A HB   1 
ATOM   1783 H  HG11 . VAL A 1 156 ? 20.07400 1.92700   19.63600 1.000 47.61659  ? 156 VAL A HG11 1 
ATOM   1784 H  HG12 . VAL A 1 156 ? 21.03600 2.17500   18.39700 1.000 47.61659  ? 156 VAL A HG12 1 
ATOM   1785 H  HG13 . VAL A 1 156 ? 21.35100 1.00700   19.42700 1.000 47.61659  ? 156 VAL A HG13 1 
ATOM   1786 H  HG21 . VAL A 1 156 ? 20.69000 2.40200   21.81700 1.000 32.27418  ? 156 VAL A HG21 1 
ATOM   1787 H  HG22 . VAL A 1 156 ? 22.17200 1.84000   21.91100 1.000 32.27418  ? 156 VAL A HG22 1 
ATOM   1788 H  HG23 . VAL A 1 156 ? 21.89200 3.38600   22.14900 1.000 32.27418  ? 156 VAL A HG23 1 
ATOM   1789 N  N    . ILE A 1 157 ? 23.71500 4.46100   18.08600 1.000 28.74418  ? 157 ILE A N    1 
ATOM   1790 C  CA   . ILE A 1 157 ? 23.91600 4.95500   16.72500 1.000 31.91701  ? 157 ILE A CA   1 
ATOM   1791 C  C    . ILE A 1 157 ? 25.15900 4.35200   16.09400 1.000 27.75890  ? 157 ILE A C    1 
ATOM   1792 O  O    . ILE A 1 157 ? 25.21400 4.15900   14.87200 1.000 31.26159  ? 157 ILE A O    1 
ATOM   1793 C  CB   . ILE A 1 157 ? 23.99500 6.49800   16.74400 1.000 28.74580  ? 157 ILE A CB   1 
ATOM   1794 C  CG1  . ILE A 1 157 ? 22.59000 7.09400   16.82500 1.000 33.79818  ? 157 ILE A CG1  1 
ATOM   1795 C  CG2  . ILE A 1 157 ? 24.74600 7.01700   15.52700 1.000 40.95110  ? 157 ILE A CG2  1 
ATOM   1796 C  CD1  . ILE A 1 157 ? 22.57200 8.57300   17.15600 1.000 33.40315  ? 157 ILE A CD1  1 
ATOM   1797 H  H    . ILE A 1 157 ? 23.71100 5.07800   18.68500 1.000 34.43278  ? 157 ILE A H    1 
ATOM   1798 H  HA   . ILE A 1 157 ? 23.15600 4.68500   16.18600 1.000 38.24017  ? 157 ILE A HA   1 
ATOM   1799 H  HB   . ILE A 1 157 ? 24.48800 6.77200   17.53200 1.000 34.43472  ? 157 ILE A HB   1 
ATOM   1800 H  HG12 . ILE A 1 157 ? 22.15200 6.97700   15.96700 1.000 40.49758  ? 157 ILE A HG12 1 
ATOM   1801 H  HG13 . ILE A 1 157 ? 22.09400 6.62900   17.51700 1.000 40.49758  ? 157 ILE A HG13 1 
ATOM   1802 H  HG21 . ILE A 1 157 ? 24.63200 7.97800   15.47100 1.000 49.08109  ? 157 ILE A HG21 1 
ATOM   1803 H  HG22 . ILE A 1 157 ? 25.68700 6.80000   15.62100 1.000 49.08109  ? 157 ILE A HG22 1 
ATOM   1804 H  HG23 . ILE A 1 157 ? 24.38800 6.59400   14.73100 1.000 49.08109  ? 157 ILE A HG23 1 
ATOM   1805 H  HD11 . ILE A 1 157 ? 21.67500 8.82600   17.42500 1.000 40.02354  ? 157 ILE A HD11 1 
ATOM   1806 H  HD12 . ILE A 1 157 ? 23.19400 8.74200   17.88000 1.000 40.02354  ? 157 ILE A HD12 1 
ATOM   1807 H  HD13 . ILE A 1 157 ? 22.83500 9.07600   16.36900 1.000 40.02354  ? 157 ILE A HD13 1 
ATOM   1808 N  N    . GLN A 1 158 ? 26.17900 4.06100   16.89600 1.000 31.30210  ? 158 GLN A N    1 
ATOM   1809 C  CA   . GLN A 1 158 ? 27.42900 3.53500   16.36900 1.000 36.45391  ? 158 GLN A CA   1 
ATOM   1810 C  C    . GLN A 1 158 ? 27.34800 2.05400   16.02500 1.000 36.67083  ? 158 GLN A C    1 
ATOM   1811 O  O    . GLN A 1 158 ? 28.30400 1.51600   15.45900 1.000 37.13947  ? 158 GLN A O    1 
ATOM   1812 C  CB   . GLN A 1 158 ? 28.54900 3.77900   17.38200 1.000 42.38159  ? 158 GLN A CB   1 
ATOM   1813 C  CG   . GLN A 1 158 ? 28.56500 5.20600   17.91000 1.000 55.65410  ? 158 GLN A CG   1 
ATOM   1814 C  CD   . GLN A 1 158 ? 29.94700 5.68700   18.29600 1.000 81.49179  ? 158 GLN A CD   1 
ATOM   1815 O  OE1  . GLN A 1 158 ? 30.72600 4.95500   18.90700 1.000 69.64532  ? 158 GLN A OE1  1 
ATOM   1816 N  NE2  . GLN A 1 158 ? 30.25500 6.93300   17.95200 1.000 95.20824  ? 158 GLN A NE2  1 
ATOM   1817 H  H    . GLN A 1 158 ? 26.17000 4.16000   17.75000 1.000 37.50228  ? 158 GLN A H    1 
ATOM   1818 H  HA   . GLN A 1 158 ? 27.65800 4.00700   15.55300 1.000 43.68445  ? 158 GLN A HA   1 
ATOM   1819 H  HB2  . GLN A 1 158 ? 28.42800 3.18100   18.13700 1.000 50.79766  ? 158 GLN A HB2  1 
ATOM   1820 H  HB3  . GLN A 1 158 ? 29.40300 3.60700   16.95600 1.000 50.79766  ? 158 GLN A HB3  1 
ATOM   1821 H  HG2  . GLN A 1 158 ? 28.22600 5.79900   17.22100 1.000 66.72468  ? 158 GLN A HG2  1 
ATOM   1822 H  HG3  . GLN A 1 158 ? 28.00200 5.25600   18.69800 1.000 66.72468  ? 158 GLN A HG3  1 
ATOM   1823 H  HE21 . GLN A 1 158 ? 29.68100 7.41800   17.53300 1.000 114.18965 ? 158 GLN A HE21 1 
ATOM   1824 H  HE22 . GLN A 1 158 ? 31.02800 7.25500   18.14800 1.000 114.18965 ? 158 GLN A HE22 1 
ATOM   1825 N  N    . MET A 1 159 ? 26.23300 1.39700   16.33400 1.000 29.52531  ? 159 MET A N    1 
ATOM   1826 C  CA   . MET A 1 159 ? 26.04700 -0.02000  16.06400 1.000 24.66740  ? 159 MET A CA   1 
ATOM   1827 C  C    . MET A 1 159 ? 25.35500 -0.24000  14.72300 1.000 34.48824  ? 159 MET A C    1 
ATOM   1828 O  O    . MET A 1 159 ? 24.68700 0.64600   14.18400 1.000 27.79907  ? 159 MET A O    1 
ATOM   1829 C  CB   . MET A 1 159 ? 25.20000 -0.67500  17.15500 1.000 29.16616  ? 159 MET A CB   1 
ATOM   1830 C  CG   . MET A 1 159 ? 25.69800 -0.49500  18.57500 1.000 36.93669  ? 159 MET A CG   1 
ATOM   1831 S  SD   . MET A 1 159 ? 24.46300 -1.00500  19.79500 1.000 48.13118  ? 159 MET A SD   1 
ATOM   1832 C  CE   . MET A 1 159 ? 23.32900 -1.98500  18.80800 1.000 46.30877  ? 159 MET A CE   1 
ATOM   1833 H  H    . MET A 1 159 ? 25.55300 1.76200   16.71200 1.000 35.37014  ? 159 MET A H    1 
ATOM   1834 H  HA   . MET A 1 159 ? 26.92400 -0.43600  16.05000 1.000 29.54064  ? 159 MET A HA   1 
ATOM   1835 H  HB2  . MET A 1 159 ? 24.30800 -0.29900  17.11400 1.000 34.93915  ? 159 MET A HB2  1 
ATOM   1836 H  HB3  . MET A 1 159 ? 25.16700 -1.62900  16.98100 1.000 34.93915  ? 159 MET A HB3  1 
ATOM   1837 H  HG2  . MET A 1 159 ? 26.49400 -1.03500  18.70500 1.000 44.26379  ? 159 MET A HG2  1 
ATOM   1838 H  HG3  . MET A 1 159 ? 25.90400 0.44100   18.72400 1.000 44.26379  ? 159 MET A HG3  1 
ATOM   1839 H  HE1  . MET A 1 159 ? 22.62800 -2.33000  19.38200 1.000 55.51028  ? 159 MET A HE1  1 
ATOM   1840 H  HE2  . MET A 1 159 ? 22.94400 -1.42300  18.11700 1.000 55.51028  ? 159 MET A HE2  1 
ATOM   1841 H  HE3  . MET A 1 159 ? 23.81700 -2.71900  18.40300 1.000 55.51028  ? 159 MET A HE3  1 
ATOM   1842 N  N    . GLU A 1 160 ? 25.50400 -1.45400  14.19900 1.000 29.77696  ? 160 GLU A N    1 
ATOM   1843 C  CA   . GLU A 1 160 ? 24.67100 -1.91600  13.09700 1.000 30.71769  ? 160 GLU A CA   1 
ATOM   1844 C  C    . GLU A 1 160 ? 23.34800 -2.41900  13.66300 1.000 37.57142  ? 160 GLU A C    1 
ATOM   1845 O  O    . GLU A 1 160 ? 23.32400 -3.39200  14.42500 1.000 39.53840  ? 160 GLU A O    1 
ATOM   1846 C  CB   . GLU A 1 160 ? 25.37200 -3.02200  12.31600 1.000 43.89591  ? 160 GLU A CB   1 
ATOM   1847 C  CG   . GLU A 1 160 ? 26.12700 -2.53300  11.09700 1.000 47.62440  ? 160 GLU A CG   1 
ATOM   1848 C  CD   . GLU A 1 160 ? 26.56700 -3.66300  10.19700 1.000 55.16621  ? 160 GLU A CD   1 
ATOM   1849 O  OE1  . GLU A 1 160 ? 26.21300 -4.82700  10.48500 1.000 51.68804  ? 160 GLU A OE1  1 
ATOM   1850 O  OE2  . GLU A 1 160 ? 27.26600 -3.39200  9.19800  1.000 56.61017  ? 160 GLU A OE2  1 
ATOM   1851 H  H    . GLU A 1 160 ? 26.08400 -2.03000  14.46700 1.000 35.67212  ? 160 GLU A H    1 
ATOM   1852 H  HA   . GLU A 1 160 ? 24.50100 -1.18200  12.48600 1.000 36.80098  ? 160 GLU A HA   1 
ATOM   1853 H  HB2  . GLU A 1 160 ? 26.01000 -3.46000  12.90100 1.000 52.61485  ? 160 GLU A HB2  1 
ATOM   1854 H  HB3  . GLU A 1 160 ? 24.70700 -3.65900  12.01400 1.000 52.61485  ? 160 GLU A HB3  1 
ATOM   1855 H  HG2  . GLU A 1 160 ? 25.55200 -1.94500  10.58300 1.000 57.08904  ? 160 GLU A HG2  1 
ATOM   1856 H  HG3  . GLU A 1 160 ? 26.91900 -2.05300  11.38700 1.000 57.08904  ? 160 GLU A HG3  1 
ATOM   1857 N  N    . LEU A 1 161 ? 22.25400 -1.76000  13.29900 1.000 33.94407  ? 161 LEU A N    1 
ATOM   1858 C  CA   . LEU A 1 161 ? 20.92600 -2.11800  13.77500 1.000 40.34841  ? 161 LEU A CA   1 
ATOM   1859 C  C    . LEU A 1 161 ? 20.08900 -2.62800  12.61000 1.000 45.58280  ? 161 LEU A C    1 
ATOM   1860 O  O    . LEU A 1 161 ? 20.04700 -1.99900  11.54800 1.000 36.29755  ? 161 LEU A O    1 
ATOM   1861 C  CB   . LEU A 1 161 ? 20.22700 -0.92100  14.42300 1.000 44.77642  ? 161 LEU A CB   1 
ATOM   1862 C  CG   . LEU A 1 161 ? 20.71500 -0.45800  15.79600 1.000 44.46910  ? 161 LEU A CG   1 
ATOM   1863 C  CD1  . LEU A 1 161 ? 20.19700 0.94600   16.07400 1.000 42.49583  ? 161 LEU A CD1  1 
ATOM   1864 C  CD2  . LEU A 1 161 ? 20.28100 -1.41900  16.89400 1.000 46.63457  ? 161 LEU A CD2  1 
ATOM   1865 H  H    . LEU A 1 161 ? 22.25800 -1.08600  12.76500 1.000 40.67265  ? 161 LEU A H    1 
ATOM   1866 H  HA   . LEU A 1 161 ? 21.00600 -2.82400  14.43600 1.000 48.35786  ? 161 LEU A HA   1 
ATOM   1867 H  HB2  . LEU A 1 161 ? 20.32500 -0.16400  13.82400 1.000 53.67147  ? 161 LEU A HB2  1 
ATOM   1868 H  HB3  . LEU A 1 161 ? 19.28900 -1.14700  14.52200 1.000 53.67147  ? 161 LEU A HB3  1 
ATOM   1869 H  HG   . LEU A 1 161 ? 21.68400 -0.44300  15.80000 1.000 53.30268  ? 161 LEU A HG   1 
ATOM   1870 H  HD11 . LEU A 1 161 ? 20.93300 1.57400   16.00200 1.000 50.93476  ? 161 LEU A HD11 1 
ATOM   1871 H  HD12 . LEU A 1 161 ? 19.51100 1.16400   15.42300 1.000 50.93476  ? 161 LEU A HD12 1 
ATOM   1872 H  HD13 . LEU A 1 161 ? 19.82500 0.97400   16.96900 1.000 50.93476  ? 161 LEU A HD13 1 
ATOM   1873 H  HD21 . LEU A 1 161 ? 20.63600 -1.11100  17.74300 1.000 55.90125  ? 161 LEU A HD21 1 
ATOM   1874 H  HD22 . LEU A 1 161 ? 19.31200 -1.44200  16.93000 1.000 55.90125  ? 161 LEU A HD22 1 
ATOM   1875 H  HD23 . LEU A 1 161 ? 20.62500 -2.30400  16.69400 1.000 55.90125  ? 161 LEU A HD23 1 
ATOM   1876 N  N    . ASP A 1 162 ? 19.42600 -3.76300  12.81100 1.000 40.03012  ? 162 ASP A N    1 
ATOM   1877 C  CA   . ASP A 1 162 ? 18.43900 -4.21700  11.84800 1.000 49.10883  ? 162 ASP A CA   1 
ATOM   1878 C  C    . ASP A 1 162 ? 17.29800 -3.20300  11.74800 1.000 43.76917  ? 162 ASP A C    1 
ATOM   1879 O  O    . ASP A 1 162 ? 17.19800 -2.25100  12.52800 1.000 33.64461  ? 162 ASP A O    1 
ATOM   1880 C  CB   . ASP A 1 162 ? 17.89000 -5.58300  12.24900 1.000 36.93172  ? 162 ASP A CB   1 
ATOM   1881 C  CG   . ASP A 1 162 ? 17.37600 -5.59900  13.66400 1.000 49.65283  ? 162 ASP A CG   1 
ATOM   1882 O  OD1  . ASP A 1 162 ? 18.21200 -5.69300  14.58100 1.000 57.41077  ? 162 ASP A OD1  1 
ATOM   1883 O  OD2  . ASP A 1 162 ? 16.14900 -5.48600  13.86200 1.000 43.42848  ? 162 ASP A OD2  1 
ATOM   1884 H  H    . ASP A 1 162 ? 19.53100 -4.28000  13.49100 1.000 47.97591  ? 162 ASP A H    1 
ATOM   1885 H  HA   . ASP A 1 162 ? 18.85500 -4.30300  10.97600 1.000 58.87035  ? 162 ASP A HA   1 
ATOM   1886 H  HB2  . ASP A 1 162 ? 17.15600 -5.81700  11.65800 1.000 44.25782  ? 162 ASP A HB2  1 
ATOM   1887 H  HB3  . ASP A 1 162 ? 18.59700 -6.24400  12.17700 1.000 44.25782  ? 162 ASP A HB3  1 
ATOM   1888 N  N    . HIS A 1 163 ? 16.41900 -3.43100  10.77300 1.000 33.86166  ? 163 HIS A N    1 
ATOM   1889 C  CA   . HIS A 1 163 ? 15.30800 -2.51100  10.55400 1.000 35.92951  ? 163 HIS A CA   1 
ATOM   1890 C  C    . HIS A 1 163 ? 14.30300 -2.55700  11.69700 1.000 31.41943  ? 163 HIS A C    1 
ATOM   1891 O  O    . HIS A 1 163 ? 13.66200 -1.54400  11.99800 1.000 25.91111  ? 163 HIS A O    1 
ATOM   1892 C  CB   . HIS A 1 163 ? 14.61300 -2.83600  9.23200  1.000 31.50379  ? 163 HIS A CB   1 
ATOM   1893 C  CG   . HIS A 1 163 ? 15.37900 -2.39200  8.02700  1.000 33.37560  ? 163 HIS A CG   1 
ATOM   1894 N  ND1  . HIS A 1 163 ? 15.72100 -1.07400  7.80700  1.000 30.16358  ? 163 HIS A ND1  1 
ATOM   1895 C  CD2  . HIS A 1 163 ? 15.87100 -3.08900  6.97700  1.000 34.15537  ? 163 HIS A CD2  1 
ATOM   1896 C  CE1  . HIS A 1 163 ? 16.39200 -0.98000  6.67400  1.000 40.05831  ? 163 HIS A CE1  1 
ATOM   1897 N  NE2  . HIS A 1 163 ? 16.49600 -2.18900  6.15000  1.000 38.20889  ? 163 HIS A NE2  1 
ATOM   1898 H  H    . HIS A 1 163 ? 16.44300 -4.10000  10.23300 1.000 40.57376  ? 163 HIS A H    1 
ATOM   1899 H  HA   . HIS A 1 163 ? 15.65900 -1.60900  10.50000 1.000 43.05518  ? 163 HIS A HA   1 
ATOM   1900 H  HB2  . HIS A 1 163 ? 14.49300 -3.79700  9.17000  1.000 37.74430  ? 163 HIS A HB2  1 
ATOM   1901 H  HB3  . HIS A 1 163 ? 13.75000 -2.39300  9.21600  1.000 37.74430  ? 163 HIS A HB3  1 
ATOM   1902 H  HD2  . HIS A 1 163 ? 15.80000 -4.00600  6.84100  1.000 40.92621  ? 163 HIS A HD2  1 
ATOM   1903 H  HE1  . HIS A 1 163 ? 16.73300 -0.19700  6.30700  1.000 48.00974  ? 163 HIS A HE1  1 
ATOM   1904 H  HE2  . HIS A 1 163 ? 16.89100 -2.38100  5.41100  1.000 45.79043  ? 163 HIS A HE2  1 
ATOM   1905 N  N    . GLU A 1 164 ? 14.15000 -3.71200  12.34600 1.000 27.47385  ? 164 GLU A N    1 
ATOM   1906 C  CA   . GLU A 1 164 ? 13.15900 -3.81300  13.41400 1.000 30.24360  ? 164 GLU A CA   1 
ATOM   1907 C  C    . GLU A 1 164 ? 13.53600 -2.92000  14.58800 1.000 28.52402  ? 164 GLU A C    1 
ATOM   1908 O  O    . GLU A 1 164 ? 12.67300 -2.25000  15.16700 1.000 27.47131  ? 164 GLU A O    1 
ATOM   1909 C  CB   . GLU A 1 164 ? 13.00400 -5.26700  13.87100 1.000 40.66775  ? 164 GLU A CB   1 
ATOM   1910 C  CG   . GLU A 1 164 ? 12.36700 -6.22300  12.84600 1.000 49.99140  ? 164 GLU A CG   1 
ATOM   1911 C  CD   . GLU A 1 164 ? 12.89900 -6.05400  11.42900 1.000 57.49692  ? 164 GLU A CD   1 
ATOM   1912 O  OE1  . GLU A 1 164 ? 14.06900 -6.41900  11.17500 1.000 48.93125  ? 164 GLU A OE1  1 
ATOM   1913 O  OE2  . GLU A 1 164 ? 12.14200 -5.55900  10.56400 1.000 54.63855  ? 164 GLU A OE2  1 
ATOM   1914 H  H    . GLU A 1 164 ? 14.59400 -4.43200  12.19100 1.000 32.90838  ? 164 GLU A H    1 
ATOM   1915 H  HA   . GLU A 1 164 ? 12.29900 -3.52300  13.07000 1.000 36.23208  ? 164 GLU A HA   1 
ATOM   1916 H  HB2  . GLU A 1 164 ? 13.88500 -5.61500  14.08100 1.000 48.74106  ? 164 GLU A HB2  1 
ATOM   1917 H  HB3  . GLU A 1 164 ? 12.44500 -5.27900  14.66300 1.000 48.74106  ? 164 GLU A HB3  1 
ATOM   1918 H  HG2  . GLU A 1 164 ? 12.54400 -7.13700  13.12000 1.000 59.92944  ? 164 GLU A HG2  1 
ATOM   1919 H  HG3  . GLU A 1 164 ? 11.41100 -6.06300  12.82200 1.000 59.92944  ? 164 GLU A HG3  1 
ATOM   1920 N  N    . ARG A 1 165 ? 14.82200 -2.87700  14.94200 1.000 27.75774  ? 165 ARG A N    1 
ATOM   1921 C  CA   . ARG A 1 165 ? 15.24000 -2.03400  16.05700 1.000 37.74606  ? 165 ARG A CA   1 
ATOM   1922 C  C    . ARG A 1 165 ? 15.26400 -0.56100  15.66400 1.000 30.76286  ? 165 ARG A C    1 
ATOM   1923 O  O    . ARG A 1 165 ? 14.81300 0.29100   16.43700 1.000 28.31063  ? 165 ARG A O    1 
ATOM   1924 C  CB   . ARG A 1 165 ? 16.60400 -2.48600  16.58100 1.000 39.20718  ? 165 ARG A CB   1 
ATOM   1925 C  CG   . ARG A 1 165 ? 16.53800 -3.84000  17.28100 1.000 46.59636  ? 165 ARG A CG   1 
ATOM   1926 C  CD   . ARG A 1 165 ? 17.89400 -4.51200  17.42200 1.000 57.55666  ? 165 ARG A CD   1 
ATOM   1927 N  NE   . ARG A 1 165 ? 17.90000 -5.44600  18.54200 1.000 65.28681  ? 165 ARG A NE   1 
ATOM   1928 C  CZ   . ARG A 1 165 ? 17.40800 -6.67800  18.49600 1.000 70.14950  ? 165 ARG A CZ   1 
ATOM   1929 N  NH1  . ARG A 1 165 ? 16.89200 -7.17600  17.38400 1.000 71.42626  ? 165 ARG A NH1  1 
ATOM   1930 N  NH2  . ARG A 1 165 ? 17.43200 -7.42700  19.59400 1.000 65.82180  ? 165 ARG A NH2  1 
ATOM   1931 H  H    . ARG A 1 165 ? 15.45500 -3.31700  14.56200 1.000 33.24904  ? 165 ARG A H    1 
ATOM   1932 H  HA   . ARG A 1 165 ? 14.60400 -2.13400  16.78200 1.000 45.23503  ? 165 ARG A HA   1 
ATOM   1933 H  HB2  . ARG A 1 165 ? 17.22000 -2.56100  15.83600 1.000 46.98838  ? 165 ARG A HB2  1 
ATOM   1934 H  HB3  . ARG A 1 165 ? 16.93100 -1.83200  17.21800 1.000 46.98838  ? 165 ARG A HB3  1 
ATOM   1935 H  HG2  . ARG A 1 165 ? 16.17500 -3.71600  18.17200 1.000 55.85539  ? 165 ARG A HG2  1 
ATOM   1936 H  HG3  . ARG A 1 165 ? 15.96600 -4.43200  16.76900 1.000 55.85539  ? 165 ARG A HG3  1 
ATOM   1937 H  HD2  . ARG A 1 165 ? 18.09700 -5.00400  16.61100 1.000 69.00776  ? 165 ARG A HD2  1 
ATOM   1938 H  HD3  . ARG A 1 165 ? 18.57400 -3.83800  17.58000 1.000 69.00776  ? 165 ARG A HD3  1 
ATOM   1939 H  HE   . ARG A 1 165 ? 18.24700 -5.18100  19.28300 1.000 78.28394  ? 165 ARG A HE   1 
ATOM   1940 H  HH11 . ARG A 1 165 ? 16.87000 -6.69900  16.66800 1.000 85.65127  ? 165 ARG A HH11 1 
ATOM   1941 H  HH12 . ARG A 1 165 ? 16.57800 -7.97700  17.37700 1.000 85.65127  ? 165 ARG A HH12 1 
ATOM   1942 H  HH21 . ARG A 1 165 ? 17.76400 -7.11300  20.32300 1.000 78.92592  ? 165 ARG A HH21 1 
ATOM   1943 H  HH22 . ARG A 1 165 ? 17.11500 -8.22700  19.57600 1.000 78.92592  ? 165 ARG A HH22 1 
ATOM   1944 N  N    A MET A 1 166 ? 15.77900 -0.23600  14.47600 0.510 29.70170  ? 166 MET A N    1 
ATOM   1945 N  N    B MET A 1 166 ? 15.76900 -0.24200  14.47000 0.490 29.73283  ? 166 MET A N    1 
ATOM   1946 C  CA   A MET A 1 166 ? 15.77900 1.15700   14.03800 0.510 27.87110  ? 166 MET A CA   1 
ATOM   1947 C  CA   B MET A 1 166 ? 15.78600 1.14900   14.02400 0.490 28.10221  ? 166 MET A CA   1 
ATOM   1948 C  C    A MET A 1 166 ? 14.36200 1.71700   14.01500 0.510 29.04161  ? 166 MET A C    1 
ATOM   1949 C  C    B MET A 1 166 ? 14.37500 1.72500   13.98900 0.490 28.81050  ? 166 MET A C    1 
ATOM   1950 O  O    A MET A 1 166 ? 14.09100 2.77500   14.59300 0.510 26.32126  ? 166 MET A O    1 
ATOM   1951 O  O    B MET A 1 166 ? 14.11900 2.80500   14.53500 0.490 26.11579  ? 166 MET A O    1 
ATOM   1952 C  CB   A MET A 1 166 ? 16.41900 1.28200   12.65600 0.510 34.07093  ? 166 MET A CB   1 
ATOM   1953 C  CB   B MET A 1 166 ? 16.44600 1.25500   12.64600 0.490 34.07343  ? 166 MET A CB   1 
ATOM   1954 C  CG   A MET A 1 166 ? 17.93500 1.17400   12.65300 0.510 39.72705  ? 166 MET A CG   1 
ATOM   1955 C  CG   B MET A 1 166 ? 17.92400 0.87500   12.62700 0.490 39.47421  ? 166 MET A CG   1 
ATOM   1956 S  SD   A MET A 1 166 ? 18.67000 1.66500   11.07800 0.510 47.80275  ? 166 MET A SD   1 
ATOM   1957 S  SD   B MET A 1 166 ? 18.75100 1.23800   11.06100 0.490 49.58194  ? 166 MET A SD   1 
ATOM   1958 C  CE   A MET A 1 166 ? 18.10200 3.35900   10.94300 0.510 30.85662  ? 166 MET A CE   1 
ATOM   1959 C  CE   B MET A 1 166 ? 18.03300 0.01000   9.96800  0.490 31.89962  ? 166 MET A CE   1 
ATOM   1960 H  H    A MET A 1 166 ? 16.12600 -0.79200  13.91900 0.510 35.58181  ? 166 MET A H    1 
ATOM   1961 H  H    B MET A 1 166 ? 16.10200 -0.80400  13.90900 0.490 35.61915  ? 166 MET A H    1 
ATOM   1962 H  HA   A MET A 1 166 ? 16.31700 1.67000   14.66100 0.510 33.38508  ? 166 MET A HA   1 
ATOM   1963 H  HA   B MET A 1 166 ? 16.32200 1.66400   14.64700 0.490 33.66242  ? 166 MET A HA   1 
ATOM   1964 H  HB2  A MET A 1 166 ? 16.07300 0.57500   12.08900 0.510 40.82488  ? 166 MET A HB2  1 
ATOM   1965 H  HB2  B MET A 1 166 ? 15.98300 0.66200   12.03400 0.490 40.82788  ? 166 MET A HB2  1 
ATOM   1966 H  HB3  A MET A 1 166 ? 16.18600 2.14800   12.28400 0.510 40.82488  ? 166 MET A HB3  1 
ATOM   1967 H  HB3  B MET A 1 166 ? 16.37500 2.17200   12.33900 0.490 40.82788  ? 166 MET A HB3  1 
ATOM   1968 H  HG2  A MET A 1 166 ? 18.29400 1.75200   13.34500 0.510 47.61222  ? 166 MET A HG2  1 
ATOM   1969 H  HG2  B MET A 1 166 ? 18.38200 1.37000   13.32500 0.490 47.30882  ? 166 MET A HG2  1 
ATOM   1970 H  HG3  A MET A 1 166 ? 18.18600 0.25300   12.82700 0.510 47.61222  ? 166 MET A HG3  1 
ATOM   1971 H  HG3  B MET A 1 166 ? 18.00300 -0.07800  12.79000 0.490 47.30882  ? 166 MET A HG3  1 
ATOM   1972 H  HE1  A MET A 1 166 ? 18.58300 3.79700   10.22300 0.510 36.96771  ? 166 MET A HE1  1 
ATOM   1973 H  HE1  B MET A 1 166 ? 18.48600 0.04500   9.11100  0.490 38.21931  ? 166 MET A HE1  1 
ATOM   1974 H  HE2  A MET A 1 166 ? 17.15100 3.35900   10.75300 0.510 36.96771  ? 166 MET A HE2  1 
ATOM   1975 H  HE2  B MET A 1 166 ? 18.14300 -0.86900  10.36400 0.490 38.21931  ? 166 MET A HE2  1 
ATOM   1976 H  HE3  A MET A 1 166 ? 18.27200 3.81700   11.78100 0.510 36.96771  ? 166 MET A HE3  1 
ATOM   1977 H  HE3  B MET A 1 166 ? 17.09000 0.20400   9.85100  0.490 38.21931  ? 166 MET A HE3  1 
ATOM   1978 N  N    . SER A 1 167 ? 13.44200 1.01500   13.35000 1.000 29.82996  ? 167 SER A N    1 
ATOM   1979 C  CA   . SER A 1 167 ? 12.07500 1.51500   13.24600 1.000 29.60856  ? 167 SER A CA   1 
ATOM   1980 C  C    . SER A 1 167 ? 11.39900 1.60300   14.61000 1.000 28.06916  ? 167 SER A C    1 
ATOM   1981 O  O    . SER A 1 167 ? 10.55500 2.48100   14.82100 1.000 25.29942  ? 167 SER A O    1 
ATOM   1982 C  CB   . SER A 1 167 ? 11.25800 0.63100   12.30500 1.000 23.98194  ? 167 SER A CB   1 
ATOM   1983 O  OG   . SER A 1 167 ? 11.23000 -0.71500  12.74600 1.000 30.75834  ? 167 SER A OG   1 
ATOM   1984 H  H    . SER A 1 167 ? 13.58500 0.26200   12.95900 1.000 35.73571  ? 167 SER A H    1 
ATOM   1985 H  HA   . SER A 1 167 ? 12.10400 2.40800   12.86900 1.000 35.47003  ? 167 SER A HA   1 
ATOM   1986 H  HB2  . SER A 1 167 ? 10.34900 0.96700   12.27000 1.000 28.71809  ? 167 SER A HB2  1 
ATOM   1987 H  HB3  . SER A 1 167 ? 11.65700 0.66200   11.42100 1.000 28.71809  ? 167 SER A HB3  1 
ATOM   1988 H  HG   . SER A 1 167 ? 12.00600 -1.03800  12.73200 1.000 36.84977  ? 167 SER A HG   1 
ATOM   1989 N  N    . TYR A 1 168 ? 11.74900 0.71500   15.54300 1.000 25.78733  ? 168 TYR A N    1 
ATOM   1990 C  CA   . TYR A 1 168 ? 11.14400 0.78400   16.87100 1.000 25.81614  ? 168 TYR A CA   1 
ATOM   1991 C  C    . TYR A 1 168 ? 11.69200 1.96500   17.66500 1.000 23.92894  ? 168 TYR A C    1 
ATOM   1992 O  O    . TYR A 1 168 ? 10.94300 2.63500   18.38600 1.000 24.34560  ? 168 TYR A O    1 
ATOM   1993 C  CB   . TYR A 1 168 ? 11.37100 -0.52400  17.63200 1.000 28.84935  ? 168 TYR A CB   1 
ATOM   1994 C  CG   . TYR A 1 168 ? 10.61900 -0.59700  18.95000 1.000 31.85292  ? 168 TYR A CG   1 
ATOM   1995 C  CD1  . TYR A 1 168 ? 9.29500  -0.19600  19.04000 1.000 32.58994  ? 168 TYR A CD1  1 
ATOM   1996 C  CD2  . TYR A 1 168 ? 11.23600 -1.06600  20.09900 1.000 31.42362  ? 168 TYR A CD2  1 
ATOM   1997 C  CE1  . TYR A 1 168 ? 8.60800  -0.26200  20.23800 1.000 34.80648  ? 168 TYR A CE1  1 
ATOM   1998 C  CE2  . TYR A 1 168 ? 10.55900 -1.13600  21.30100 1.000 32.54704  ? 168 TYR A CE2  1 
ATOM   1999 C  CZ   . TYR A 1 168 ? 9.24600  -0.73200  21.36500 1.000 33.88442  ? 168 TYR A CZ   1 
ATOM   2000 O  OH   . TYR A 1 168 ? 8.56600  -0.79600  22.55900 1.000 38.15987  ? 168 TYR A OH   1 
ATOM   2001 H  H    . TYR A 1 168 ? 12.32000 0.08100   15.43500 1.000 30.88455  ? 168 TYR A H    1 
ATOM   2002 H  HA   . TYR A 1 168 ? 10.18700 0.90300   16.76800 1.000 30.91913  ? 168 TYR A HA   1 
ATOM   2003 H  HB2  . TYR A 1 168 ? 11.07300 -1.26300  17.07900 1.000 34.55898  ? 168 TYR A HB2  1 
ATOM   2004 H  HB3  . TYR A 1 168 ? 12.31700 -0.61400  17.82400 1.000 34.55898  ? 168 TYR A HB3  1 
ATOM   2005 H  HD1  . TYR A 1 168 ? 8.86100  0.12300   18.28200 1.000 39.04769  ? 168 TYR A HD1  1 
ATOM   2006 H  HD2  . TYR A 1 168 ? 12.12400 -1.34000  20.06000 1.000 37.64811  ? 168 TYR A HD2  1 
ATOM   2007 H  HE1  . TYR A 1 168 ? 7.72000  0.01000   20.28300 1.000 41.70753  ? 168 TYR A HE1  1 
ATOM   2008 H  HE2  . TYR A 1 168 ? 10.98800 -1.45400  22.06200 1.000 38.99621  ? 168 TYR A HE2  1 
ATOM   2009 H  HH   . TYR A 1 168 ? 9.06800  -1.09900  23.16000 1.000 45.73161  ? 168 TYR A HH   1 
ATOM   2010 N  N    . LEU A 1 169 ? 12.99600 2.23100   17.55500 1.000 25.21943  ? 169 LEU A N    1 
ATOM   2011 C  CA   . LEU A 1 169 ? 13.56300 3.40800   18.20600 1.000 22.04490  ? 169 LEU A CA   1 
ATOM   2012 C  C    . LEU A 1 169 ? 12.94500 4.68500   17.65400 1.000 25.80202  ? 169 LEU A C    1 
ATOM   2013 O  O    . LEU A 1 169 ? 12.60300 5.60200   18.41400 1.000 23.45450  ? 169 LEU A O    1 
ATOM   2014 C  CB   . LEU A 1 169 ? 15.08100 3.43200   18.02200 1.000 23.38144  ? 169 LEU A CB   1 
ATOM   2015 C  CG   . LEU A 1 169 ? 15.87100 2.30100   18.68500 1.000 22.69149  ? 169 LEU A CG   1 
ATOM   2016 C  CD1  . LEU A 1 169 ? 17.31500 2.30500   18.20000 1.000 28.90843  ? 169 LEU A CD1  1 
ATOM   2017 C  CD2  . LEU A 1 169 ? 15.81400 2.41300   20.19600 1.000 28.77100  ? 169 LEU A CD2  1 
ATOM   2018 H  H    . LEU A 1 169 ? 13.56200 1.75400   17.11700 1.000 30.20307  ? 169 LEU A H    1 
ATOM   2019 H  HA   . LEU A 1 169 ? 13.37600 3.36000   19.15600 1.000 26.39364  ? 169 LEU A HA   1 
ATOM   2020 H  HB2  . LEU A 1 169 ? 15.26800 3.39100   17.07100 1.000 27.99749  ? 169 LEU A HB2  1 
ATOM   2021 H  HB3  . LEU A 1 169 ? 15.41400 4.26500   18.39000 1.000 27.99749  ? 169 LEU A HB3  1 
ATOM   2022 H  HG   . LEU A 1 169 ? 15.47000 1.45300   18.43700 1.000 27.16955  ? 169 LEU A HG   1 
ATOM   2023 H  HD11 . LEU A 1 169 ? 17.80000 1.59300   18.64500 1.000 34.62987  ? 169 LEU A HD11 1 
ATOM   2024 H  HD12 . LEU A 1 169 ? 17.32700 2.16400   17.24000 1.000 34.62987  ? 169 LEU A HD12 1 
ATOM   2025 H  HD13 . LEU A 1 169 ? 17.71700 3.16200   18.41300 1.000 34.62987  ? 169 LEU A HD13 1 
ATOM   2026 H  HD21 . LEU A 1 169 ? 16.40000 1.74400   20.58500 1.000 34.46497  ? 169 LEU A HD21 1 
ATOM   2027 H  HD22 . LEU A 1 169 ? 16.10500 3.30000   20.45900 1.000 34.46497  ? 169 LEU A HD22 1 
ATOM   2028 H  HD23 . LEU A 1 169 ? 14.90200 2.26400   20.49000 1.000 34.46497  ? 169 LEU A HD23 1 
ATOM   2029 N  N    . LEU A 1 170 ? 12.79700 4.76500   16.32800 1.000 19.04812  ? 170 LEU A N    1 
ATOM   2030 C  CA   . LEU A 1 170 ? 12.21500 5.95200   15.71600 1.000 22.00199  ? 170 LEU A CA   1 
ATOM   2031 C  C    . LEU A 1 170 ? 10.74300 6.08700   16.07500 1.000 20.61374  ? 170 LEU A C    1 
ATOM   2032 O  O    . LEU A 1 170 ? 10.25700 7.19900   16.31900 1.000 23.49947  ? 170 LEU A O    1 
ATOM   2033 C  CB   . LEU A 1 170 ? 12.39300 5.89600   14.19600 1.000 21.90801  ? 170 LEU A CB   1 
ATOM   2034 C  CG   . LEU A 1 170 ? 13.84600 5.98000   13.72900 1.000 22.59763  ? 170 LEU A CG   1 
ATOM   2035 C  CD1  . LEU A 1 170 ? 13.98500 5.45100   12.30200 1.000 32.26555  ? 170 LEU A CD1  1 
ATOM   2036 C  CD2  . LEU A 1 170 ? 14.35900 7.40700   13.83000 1.000 25.59201  ? 170 LEU A CD2  1 
ATOM   2037 H  H    . LEU A 1 170 ? 13.02500 4.15200   15.77000 1.000 22.79751  ? 170 LEU A H    1 
ATOM   2038 H  HA   . LEU A 1 170 ? 12.68000 6.73700   16.04600 1.000 26.34215  ? 170 LEU A HA   1 
ATOM   2039 H  HB2  . LEU A 1 170 ? 12.02900 5.05700   13.87300 1.000 26.22938  ? 170 LEU A HB2  1 
ATOM   2040 H  HB3  . LEU A 1 170 ? 11.91300 6.64000   13.80100 1.000 26.22938  ? 170 LEU A HB3  1 
ATOM   2041 H  HG   . LEU A 1 170 ? 14.39500 5.42600   14.30500 1.000 27.05692  ? 170 LEU A HG   1 
ATOM   2042 H  HD11 . LEU A 1 170 ? 14.92600 5.42200   12.06600 1.000 38.65842  ? 170 LEU A HD11 1 
ATOM   2043 H  HD12 . LEU A 1 170 ? 13.60600 4.55900   12.25700 1.000 38.65842  ? 170 LEU A HD12 1 
ATOM   2044 H  HD13 . LEU A 1 170 ? 13.51100 6.04300   11.69700 1.000 38.65842  ? 170 LEU A HD13 1 
ATOM   2045 H  HD21 . LEU A 1 170 ? 15.26500 7.44200   13.48400 1.000 30.65018  ? 170 LEU A HD21 1 
ATOM   2046 H  HD22 . LEU A 1 170 ? 13.78300 7.98700   13.30900 1.000 30.65018  ? 170 LEU A HD22 1 
ATOM   2047 H  HD23 . LEU A 1 170 ? 14.35000 7.68000   14.76100 1.000 30.65018  ? 170 LEU A HD23 1 
ATOM   2048 N  N    . TYR A 1 171 ? 10.01700 4.97100   16.10700 1.000 20.66972  ? 171 TYR A N    1 
ATOM   2049 C  CA   . TYR A 1 171 ? 8.62000  5.01900   16.51700 1.000 25.72373  ? 171 TYR A CA   1 
ATOM   2050 C  C    . TYR A 1 171 ? 8.48800  5.59300   17.92200 1.000 26.49814  ? 171 TYR A C    1 
ATOM   2051 O  O    . TYR A 1 171 ? 7.61400  6.42700   18.18200 1.000 23.94780  ? 171 TYR A O    1 
ATOM   2052 C  CB   . TYR A 1 171 ? 8.01200  3.61800   16.45100 1.000 24.13571  ? 171 TYR A CB   1 
ATOM   2053 C  CG   . TYR A 1 171 ? 6.67200  3.49800   17.13500 1.000 23.10989  ? 171 TYR A CG   1 
ATOM   2054 C  CD1  . TYR A 1 171 ? 5.51500  3.96500   16.52500 1.000 31.53642  ? 171 TYR A CD1  1 
ATOM   2055 C  CD2  . TYR A 1 171 ? 6.56300  2.92400   18.39400 1.000 27.43070  ? 171 TYR A CD2  1 
ATOM   2056 C  CE1  . TYR A 1 171 ? 4.28700  3.85800   17.14900 1.000 41.81286  ? 171 TYR A CE1  1 
ATOM   2057 C  CE2  . TYR A 1 171 ? 5.34000  2.81200   19.02400 1.000 29.20210  ? 171 TYR A CE2  1 
ATOM   2058 C  CZ   . TYR A 1 171 ? 4.20600  3.28100   18.39900 1.000 37.34333  ? 171 TYR A CZ   1 
ATOM   2059 O  OH   . TYR A 1 171 ? 2.98700  3.17300   19.02700 1.000 50.55360  ? 171 TYR A OH   1 
ATOM   2060 H  H    . TYR A 1 171 ? 10.30600 4.18800   15.89900 1.000 24.74343  ? 171 TYR A H    1 
ATOM   2061 H  HA   . TYR A 1 171 ? 8.12700  5.59000   15.90700 1.000 30.80824  ? 171 TYR A HA   1 
ATOM   2062 H  HB2  . TYR A 1 171 ? 7.89000  3.37500   15.51900 1.000 28.90262  ? 171 TYR A HB2  1 
ATOM   2063 H  HB3  . TYR A 1 171 ? 8.61900  2.99400   16.87900 1.000 28.90262  ? 171 TYR A HB3  1 
ATOM   2064 H  HD1  . TYR A 1 171 ? 5.56800  4.35500   15.68300 1.000 37.78346  ? 171 TYR A HD1  1 
ATOM   2065 H  HD2  . TYR A 1 171 ? 7.32700  2.60900   18.82000 1.000 32.85661  ? 171 TYR A HD2  1 
ATOM   2066 H  HE1  . TYR A 1 171 ? 3.52000  4.17400   16.72900 1.000 50.11519  ? 171 TYR A HE1  1 
ATOM   2067 H  HE2  . TYR A 1 171 ? 5.28200  2.42300   19.86700 1.000 34.98228  ? 171 TYR A HE2  1 
ATOM   2068 H  HH   . TYR A 1 171 ? 3.08400  2.82300   19.78500 1.000 60.60409  ? 171 TYR A HH   1 
ATOM   2069 N  N    . GLN A 1 172 ? 9.35900  5.16700   18.83800 1.000 22.16954  ? 172 GLN A N    1 
ATOM   2070 C  CA   . GLN A 1 172 ? 9.27900  5.64900   20.21400 1.000 26.07251  ? 172 GLN A CA   1 
ATOM   2071 C  C    . GLN A 1 172 ? 9.65200  7.12100   20.30500 1.000 25.18531  ? 172 GLN A C    1 
ATOM   2072 O  O    . GLN A 1 172 ? 9.04400  7.87700   21.07200 1.000 25.09201  ? 172 GLN A O    1 
ATOM   2073 C  CB   . GLN A 1 172 ? 10.18900 4.81500   21.10800 1.000 24.40578  ? 172 GLN A CB   1 
ATOM   2074 C  CG   . GLN A 1 172 ? 9.72100  3.39500   21.30500 1.000 27.59478  ? 172 GLN A CG   1 
ATOM   2075 C  CD   . GLN A 1 172 ? 10.69200 2.59400   22.13500 1.000 29.25160  ? 172 GLN A CD   1 
ATOM   2076 O  OE1  . GLN A 1 172 ? 10.55700 2.50500   23.35500 1.000 29.75315  ? 172 GLN A OE1  1 
ATOM   2077 N  NE2  . GLN A 1 172 ? 11.69100 2.01200   21.47900 1.000 27.99357  ? 172 GLN A NE2  1 
ATOM   2078 H  H    . GLN A 1 172 ? 9.99600  4.60900   18.69000 1.000 26.54321  ? 172 GLN A H    1 
ATOM   2079 H  HA   . GLN A 1 172 ? 8.36600  5.54800   20.52800 1.000 31.22678  ? 172 GLN A HA   1 
ATOM   2080 H  HB2  . GLN A 1 172 ? 11.07200 4.78200   20.70800 1.000 29.22669  ? 172 GLN A HB2  1 
ATOM   2081 H  HB3  . GLN A 1 172 ? 10.23600 5.23500   21.98200 1.000 29.22669  ? 172 GLN A HB3  1 
ATOM   2082 H  HG2  . GLN A 1 172 ? 8.86500  3.40200   21.76200 1.000 33.05350  ? 172 GLN A HG2  1 
ATOM   2083 H  HG3  . GLN A 1 172 ? 9.63300  2.96500   20.44100 1.000 33.05350  ? 172 GLN A HG3  1 
ATOM   2084 H  HE21 . GLN A 1 172 ? 11.75600 2.10400   20.62600 1.000 33.53204  ? 172 GLN A HE21 1 
ATOM   2085 H  HE22 . GLN A 1 172 ? 12.27100 1.54400   21.90700 1.000 33.53204  ? 172 GLN A HE22 1 
ATOM   2086 N  N    . MET A 1 173 ? 10.66100 7.54100   19.54100 1.000 27.31165  ? 173 MET A N    1 
ATOM   2087 C  CA   . MET A 1 173 ? 11.01200 8.95500   19.49000 1.000 20.74388  ? 173 MET A CA   1 
ATOM   2088 C  C    . MET A 1 173 ? 9.81600  9.79200   19.05600 1.000 26.47995  ? 173 MET A C    1 
ATOM   2089 O  O    . MET A 1 173 ? 9.52500  10.83400  19.65400 1.000 24.91915  ? 173 MET A O    1 
ATOM   2090 C  CB   . MET A 1 173 ? 12.19200 9.15600   18.53700 1.000 28.64044  ? 173 MET A CB   1 
ATOM   2091 C  CG   . MET A 1 173 ? 13.53300 9.30600   19.22800 1.000 37.86425  ? 173 MET A CG   1 
ATOM   2092 S  SD   . MET A 1 173 ? 14.91700 9.38200   18.07100 1.000 40.17972  ? 173 MET A SD   1 
ATOM   2093 C  CE   . MET A 1 173 ? 15.05200 7.68000   17.56300 1.000 43.39026  ? 173 MET A CE   1 
ATOM   2094 H  H    . MET A 1 173 ? 11.15100 7.03300   19.04900 1.000 32.71374  ? 173 MET A H    1 
ATOM   2095 H  HA   . MET A 1 173 ? 11.29100 9.24800   20.37200 1.000 24.83242  ? 173 MET A HA   1 
ATOM   2096 H  HB2  . MET A 1 173 ? 12.24900 8.38700   17.94900 1.000 34.30829  ? 173 MET A HB2  1 
ATOM   2097 H  HB3  . MET A 1 173 ? 12.03700 9.96000   18.01800 1.000 34.30829  ? 173 MET A HB3  1 
ATOM   2098 H  HG2  . MET A 1 173 ? 13.53100 10.12700  19.74600 1.000 45.37686  ? 173 MET A HG2  1 
ATOM   2099 H  HG3  . MET A 1 173 ? 13.67300 8.54500   19.81300 1.000 45.37686  ? 173 MET A HG3  1 
ATOM   2100 H  HE1  . MET A 1 173 ? 15.72000 7.61200   16.86300 1.000 52.00808  ? 173 MET A HE1  1 
ATOM   2101 H  HE2  . MET A 1 173 ? 15.31700 7.14300   18.32600 1.000 52.00808  ? 173 MET A HE2  1 
ATOM   2102 H  HE3  . MET A 1 173 ? 14.19200 7.38000   17.23000 1.000 52.00808  ? 173 MET A HE3  1 
ATOM   2103 N  N    . LEU A 1 174 ? 9.09900  9.33900   18.02400 1.000 28.34908  ? 174 LEU A N    1 
ATOM   2104 C  CA   . LEU A 1 174 ? 7.94200  10.08100  17.53400 1.000 25.83694  ? 174 LEU A CA   1 
ATOM   2105 C  C    . LEU A 1 174 ? 6.80300  10.07800  18.54800 1.000 24.36327  ? 174 LEU A C    1 
ATOM   2106 O  O    . LEU A 1 174 ? 6.11200  11.09100  18.71200 1.000 28.36275  ? 174 LEU A O    1 
ATOM   2107 C  CB   . LEU A 1 174 ? 7.47800  9.49300   16.19900 1.000 28.80305  ? 174 LEU A CB   1 
ATOM   2108 C  CG   . LEU A 1 174 ? 8.46000  9.66700   15.03900 1.000 28.07443  ? 174 LEU A CG   1 
ATOM   2109 C  CD1  . LEU A 1 174 ? 8.11700  8.74100   13.88000 1.000 25.09544  ? 174 LEU A CD1  1 
ATOM   2110 C  CD2  . LEU A 1 174 ? 8.46600  11.11300  14.56500 1.000 26.73771  ? 174 LEU A CD2  1 
ATOM   2111 H  H    . LEU A 1 174 ? 9.26100  8.61100   17.59600 1.000 33.95866  ? 174 LEU A H    1 
ATOM   2112 H  HA   . LEU A 1 174 ? 8.20100  11.00400  17.38600 1.000 30.94409  ? 174 LEU A HA   1 
ATOM   2113 H  HB2  . LEU A 1 174 ? 7.33300  8.54100   16.31700 1.000 34.50342  ? 174 LEU A HB2  1 
ATOM   2114 H  HB3  . LEU A 1 174 ? 6.64700  9.92600   15.94500 1.000 34.50342  ? 174 LEU A HB3  1 
ATOM   2115 H  HG   . LEU A 1 174 ? 9.34800  9.43500   15.35300 1.000 33.62908  ? 174 LEU A HG   1 
ATOM   2116 H  HD11 . LEU A 1 174 ? 8.75900  8.88000   13.16600 1.000 30.05429  ? 174 LEU A HD11 1 
ATOM   2117 H  HD12 . LEU A 1 174 ? 8.15800  7.82200   14.18800 1.000 30.05429  ? 174 LEU A HD12 1 
ATOM   2118 H  HD13 . LEU A 1 174 ? 7.22300  8.94600   13.56600 1.000 30.05429  ? 174 LEU A HD13 1 
ATOM   2119 H  HD21 . LEU A 1 174 ? 9.07000  11.19500  13.81000 1.000 32.02501  ? 174 LEU A HD21 1 
ATOM   2120 H  HD22 . LEU A 1 174 ? 7.56700  11.36200  14.29900 1.000 32.02501  ? 174 LEU A HD22 1 
ATOM   2121 H  HD23 . LEU A 1 174 ? 8.76600  11.68200  15.29100 1.000 32.02501  ? 174 LEU A HD23 1 
ATOM   2122 N  N    . CYS A 1 175 ? 6.58300  8.95200   19.23500 1.000 24.51178  ? 175 CYS A N    1 
ATOM   2123 C  CA   . CYS A 1 175 ? 5.56200  8.92000   20.28100 1.000 25.40080  ? 175 CYS A CA   1 
ATOM   2124 C  C    . CYS A 1 175 ? 5.86200  9.94900   21.36500 1.000 28.77275  ? 175 CYS A C    1 
ATOM   2125 O  O    . CYS A 1 175 ? 4.98300  10.72000  21.76500 1.000 30.77774  ? 175 CYS A O    1 
ATOM   2126 C  CB   . CYS A 1 175 ? 5.46300  7.52100   20.89200 1.000 30.71089  ? 175 CYS A CB   1 
ATOM   2127 S  SG   . CYS A 1 175 ? 4.76900  6.25000   19.79300 1.000 38.53530  ? 175 CYS A SG   1 
ATOM   2128 H  H    . CYS A 1 175 ? 7.00300  8.21100   19.11600 1.000 29.35390  ? 175 CYS A H    1 
ATOM   2129 H  HA   . CYS A 1 175 ? 4.70400  9.13200   19.87900 1.000 30.42072  ? 175 CYS A HA   1 
ATOM   2130 H  HB2  . CYS A 1 175 ? 6.35500  7.23200   21.14300 1.000 36.79283  ? 175 CYS A HB2  1 
ATOM   2131 H  HB3  . CYS A 1 175 ? 4.89600  7.56800   21.67700 1.000 36.79283  ? 175 CYS A HB3  1 
ATOM   2132 H  HG   . CYS A 1 175 ? 5.41000  6.21800   18.77900 1.000 46.18212  ? 175 CYS A HG   1 
ATOM   2133 N  N    . GLY A 1 176 ? 7.10200  9.97100   21.85500 1.000 26.55634  ? 176 GLY A N    1 
ATOM   2134 C  CA   . GLY A 1 176 ? 7.46100  10.94200  22.87900 1.000 25.23757  ? 176 GLY A CA   1 
ATOM   2135 C  C    . GLY A 1 176 ? 7.27900  12.37100  22.40700 1.000 29.30129  ? 176 GLY A C    1 
ATOM   2136 O  O    . GLY A 1 176 ? 6.67600  13.19600  23.09700 1.000 36.18317  ? 176 GLY A O    1 
ATOM   2137 H  H    . GLY A 1 176 ? 7.74000  9.44600   21.61600 1.000 31.80737  ? 176 GLY A H    1 
ATOM   2138 H  HA2  . GLY A 1 176 ? 6.90300  10.80500  23.66100 1.000 30.22485  ? 176 GLY A HA2  1 
ATOM   2139 H  HA3  . GLY A 1 176 ? 8.39000  10.81800  23.12800 1.000 30.22485  ? 176 GLY A HA3  1 
ATOM   2140 N  N    . ILE A 1 177 ? 7.80300  12.68300  21.21900 1.000 26.74890  ? 177 ILE A N    1 
ATOM   2141 C  CA   . ILE A 1 177 ? 7.64400  14.02200  20.65800 1.000 26.45368  ? 177 ILE A CA   1 
ATOM   2142 C  C    . ILE A 1 177 ? 6.16700  14.37900  20.54400 1.000 32.53733  ? 177 ILE A C    1 
ATOM   2143 O  O    . ILE A 1 177 ? 5.76000  15.51000  20.84000 1.000 30.33658  ? 177 ILE A O    1 
ATOM   2144 C  CB   . ILE A 1 177 ? 8.34900  14.11400  19.29200 1.000 33.58677  ? 177 ILE A CB   1 
ATOM   2145 C  CG1  . ILE A 1 177 ? 9.85800  13.89700  19.44400 1.000 38.81075  ? 177 ILE A CG1  1 
ATOM   2146 C  CG2  . ILE A 1 177 ? 8.05200  15.44600  18.63500 1.000 36.49588  ? 177 ILE A CG2  1 
ATOM   2147 C  CD1  . ILE A 1 177 ? 10.57400 14.99900  20.18600 1.000 40.84176  ? 177 ILE A CD1  1 
ATOM   2148 H  H    . ILE A 1 177 ? 8.25000  12.14100  20.72200 1.000 32.03844  ? 177 ILE A H    1 
ATOM   2149 H  HA   . ILE A 1 177 ? 8.06100  14.65800  21.25900 1.000 31.68418  ? 177 ILE A HA   1 
ATOM   2150 H  HB   . ILE A 1 177 ? 8.00500  13.40900  18.72200 1.000 40.24389  ? 177 ILE A HB   1 
ATOM   2151 H  HG12 . ILE A 1 177 ? 10.00500 13.07100  19.93200 1.000 46.51266  ? 177 ILE A HG12 1 
ATOM   2152 H  HG13 . ILE A 1 177 ? 10.25200 13.83400  18.56000 1.000 46.51266  ? 177 ILE A HG13 1 
ATOM   2153 H  HG21 . ILE A 1 177 ? 8.70300  15.60400  17.93300 1.000 43.73482  ? 177 ILE A HG21 1 
ATOM   2154 H  HG22 . ILE A 1 177 ? 7.15900  15.41900  18.25700 1.000 43.73482  ? 177 ILE A HG22 1 
ATOM   2155 H  HG23 . ILE A 1 177 ? 8.10800  16.14700  19.30300 1.000 43.73482  ? 177 ILE A HG23 1 
ATOM   2156 H  HD11 . ILE A 1 177 ? 11.52000 14.78700  20.23100 1.000 48.94987  ? 177 ILE A HD11 1 
ATOM   2157 H  HD12 . ILE A 1 177 ? 10.44500 15.83500  19.71100 1.000 48.94987  ? 177 ILE A HD12 1 
ATOM   2158 H  HD13 . ILE A 1 177 ? 10.20700 15.06800  21.08100 1.000 48.94987  ? 177 ILE A HD13 1 
ATOM   2159 N  N    . LYS A 1 178 ? 5.34400  13.42700  20.10600 1.000 31.98765  ? 178 LYS A N    1 
ATOM   2160 C  CA   . LYS A 1 178 ? 3.91300  13.68600  20.00000 1.000 31.87216  ? 178 LYS A CA   1 
ATOM   2161 C  C    . LYS A 1 178 ? 3.30400  13.98300  21.36600 1.000 33.89049  ? 178 LYS A C    1 
ATOM   2162 O  O    . LYS A 1 178 ? 2.44500  14.86500  21.49100 1.000 32.68522  ? 178 LYS A O    1 
ATOM   2163 C  CB   . LYS A 1 178 ? 3.21700  12.49400  19.35300 1.000 34.58231  ? 178 LYS A CB   1 
ATOM   2164 C  CG   . LYS A 1 178 ? 1.71000  12.55100  19.43100 1.000 45.05494  ? 178 LYS A CG   1 
ATOM   2165 C  CD   . LYS A 1 178 ? 1.11300  11.23300  19.00200 1.000 70.00842  ? 178 LYS A CD   1 
ATOM   2166 C  CE   . LYS A 1 178 ? -0.39800 11.28100  19.04800 1.000 87.49468  ? 178 LYS A CE   1 
ATOM   2167 N  NZ   . LYS A 1 178 ? -0.96200 12.10100  17.94500 1.000 77.72802  ? 178 LYS A NZ   1 
ATOM   2168 H  H    . LYS A 1 178 ? 5.58500  12.63600  19.86700 1.000 38.32494  ? 178 LYS A H    1 
ATOM   2169 H  HA   . LYS A 1 178 ? 3.77400  14.46200  19.43500 1.000 38.18636  ? 178 LYS A HA   1 
ATOM   2170 H  HB2  . LYS A 1 178 ? 3.46400  12.46000  18.41500 1.000 41.43853  ? 178 LYS A HB2  1 
ATOM   2171 H  HB3  . LYS A 1 178 ? 3.50600  11.68300  19.80100 1.000 41.43853  ? 178 LYS A HB3  1 
ATOM   2172 H  HG2  . LYS A 1 178 ? 1.43800  12.73100  20.34400 1.000 54.00569  ? 178 LYS A HG2  1 
ATOM   2173 H  HG3  . LYS A 1 178 ? 1.38000  13.24700  18.84200 1.000 54.00569  ? 178 LYS A HG3  1 
ATOM   2174 H  HD2  . LYS A 1 178 ? 1.38600  11.03600  18.09200 1.000 83.94987  ? 178 LYS A HD2  1 
ATOM   2175 H  HD3  . LYS A 1 178 ? 1.41600  10.53100  19.59900 1.000 83.94987  ? 178 LYS A HD3  1 
ATOM   2176 H  HE2  . LYS A 1 178 ? -0.74900 10.38100  18.96600 1.000 104.93337 ? 178 LYS A HE2  1 
ATOM   2177 H  HE3  . LYS A 1 178 ? -0.67900 11.67200  19.89000 1.000 104.93337 ? 178 LYS A HE3  1 
ATOM   2178 H  HZ1  . LYS A 1 178 ? -1.84600 12.15500  18.02700 1.000 93.21338  ? 178 LYS A HZ1  1 
ATOM   2179 H  HZ2  . LYS A 1 178 ? -0.61900 12.92200  17.97000 1.000 93.21338  ? 178 LYS A HZ2  1 
ATOM   2180 H  HZ3  . LYS A 1 178 ? -0.76700 11.73100  17.15900 1.000 93.21338  ? 178 LYS A HZ3  1 
ATOM   2181 N  N    . HIS A 1 179 ? 3.72000  13.24700  22.39700 1.000 28.86721  ? 179 HIS A N    1 
ATOM   2182 C  CA   . HIS A 1 179 ? 3.22300  13.52700  23.74000 1.000 37.93945  ? 179 HIS A CA   1 
ATOM   2183 C  C    . HIS A 1 179 ? 3.63300  14.92200  24.19300 1.000 32.14868  ? 179 HIS A C    1 
ATOM   2184 O  O    . HIS A 1 179 ? 2.82300  15.66400  24.75900 1.000 35.76809  ? 179 HIS A O    1 
ATOM   2185 C  CB   . HIS A 1 179 ? 3.73600  12.47500  24.72000 1.000 34.58597  ? 179 HIS A CB   1 
ATOM   2186 C  CG   . HIS A 1 179 ? 3.15800  12.60100  26.09500 1.000 34.74532  ? 179 HIS A CG   1 
ATOM   2187 N  ND1  . HIS A 1 179 ? 1.89400  12.15500  26.41500 1.000 40.40544  ? 179 HIS A ND1  1 
ATOM   2188 C  CD2  . HIS A 1 179 ? 3.67100  13.12600  27.23200 1.000 35.82350  ? 179 HIS A CD2  1 
ATOM   2189 C  CE1  . HIS A 1 179 ? 1.65400  12.39700  27.69100 1.000 47.73438  ? 179 HIS A CE1  1 
ATOM   2190 N  NE2  . HIS A 1 179 ? 2.71700  12.98500  28.21000 1.000 35.23519  ? 179 HIS A NE2  1 
ATOM   2191 H  H    . HIS A 1 179 ? 4.27700  12.59400  22.34500 1.000 34.58041  ? 179 HIS A H    1 
ATOM   2192 H  HA   . HIS A 1 179 ? 2.25400  13.48100  23.73200 1.000 45.46710  ? 179 HIS A HA   1 
ATOM   2193 H  HB2  . HIS A 1 179 ? 3.50600  11.59500  24.38200 1.000 41.44293  ? 179 HIS A HB2  1 
ATOM   2194 H  HB3  . HIS A 1 179 ? 4.69900  12.56100  24.79500 1.000 41.44293  ? 179 HIS A HB3  1 
ATOM   2195 H  HD1  . HIS A 1 179 ? 1.34600  11.77800  25.86900 1.000 48.42629  ? 179 HIS A HD1  1 
ATOM   2196 H  HD2  . HIS A 1 179 ? 4.51200  13.51000  27.33300 1.000 42.92796  ? 179 HIS A HD2  1 
ATOM   2197 H  HE1  . HIS A 1 179 ? 0.87000  12.19000  28.14700 1.000 57.22102  ? 179 HIS A HE1  1 
ATOM   2198 N  N    . LEU A 1 180 ? 4.89100  15.29500  23.95100 1.000 28.08969  ? 180 LEU A N    1 
ATOM   2199 C  CA   . LEU A 1 180 ? 5.34300  16.64200  24.28900 1.000 31.96375  ? 180 LEU A CA   1 
ATOM   2200 C  C    . LEU A 1 180 ? 4.49400  17.69300  23.58500 1.000 32.72726  ? 180 LEU A C    1 
ATOM   2201 O  O    . LEU A 1 180 ? 4.03800  18.65900  24.20800 1.000 34.95452  ? 180 LEU A O    1 
ATOM   2202 C  CB   . LEU A 1 180 ? 6.81700  16.80400  23.91700 1.000 31.13583  ? 180 LEU A CB   1 
ATOM   2203 C  CG   . LEU A 1 180 ? 7.82300  16.04000  24.77900 1.000 29.52222  ? 180 LEU A CG   1 
ATOM   2204 C  CD1  . LEU A 1 180 ? 9.23200  16.23600  24.25000 1.000 29.39005  ? 180 LEU A CD1  1 
ATOM   2205 C  CD2  . LEU A 1 180 ? 7.74000  16.48800  26.23400 1.000 27.58173  ? 180 LEU A CD2  1 
ATOM   2206 H  H    . LEU A 1 180 ? 5.49400  14.79400  23.59800 1.000 33.64739  ? 180 LEU A H    1 
ATOM   2207 H  HA   . LEU A 1 180 ? 5.25500  16.77300  25.24600 1.000 38.29626  ? 180 LEU A HA   1 
ATOM   2208 H  HB2  . LEU A 1 180 ? 6.93200  16.49700  23.00400 1.000 37.30276  ? 180 LEU A HB2  1 
ATOM   2209 H  HB3  . LEU A 1 180 ? 7.04200  17.74500  23.98200 1.000 37.30276  ? 180 LEU A HB3  1 
ATOM   2210 H  HG   . LEU A 1 180 ? 7.61000  15.09400  24.74200 1.000 35.36642  ? 180 LEU A HG   1 
ATOM   2211 H  HD11 . LEU A 1 180 ? 9.84400  15.69400  24.77200 1.000 35.20783  ? 180 LEU A HD11 1 
ATOM   2212 H  HD12 . LEU A 1 180 ? 9.26100  15.96400  23.31900 1.000 35.20783  ? 180 LEU A HD12 1 
ATOM   2213 H  HD13 . LEU A 1 180 ? 9.47100  17.17300  24.32900 1.000 35.20783  ? 180 LEU A HD13 1 
ATOM   2214 H  HD21 . LEU A 1 180 ? 8.50700  16.14100  26.71500 1.000 33.03784  ? 180 LEU A HD21 1 
ATOM   2215 H  HD22 . LEU A 1 180 ? 7.73900  17.45700  26.26600 1.000 33.03784  ? 180 LEU A HD22 1 
ATOM   2216 H  HD23 . LEU A 1 180 ? 6.92100  16.14300  26.62400 1.000 33.03784  ? 180 LEU A HD23 1 
ATOM   2217 N  N    . HIS A 1 181 ? 4.26600  17.51700  22.28100 1.000 30.58141  ? 181 HIS A N    1 
ATOM   2218 C  CA   . HIS A 1 181 ? 3.49100  18.50300  21.53300 1.000 31.01494  ? 181 HIS A CA   1 
ATOM   2219 C  C    . HIS A 1 181 ? 2.06900  18.60600  22.06500 1.000 30.54864  ? 181 HIS A C    1 
ATOM   2220 O  O    . HIS A 1 181 ? 1.51200  19.70500  22.15800 1.000 34.62895  ? 181 HIS A O    1 
ATOM   2221 C  CB   . HIS A 1 181 ? 3.47200  18.14000  20.04700 1.000 33.82916  ? 181 HIS A CB   1 
ATOM   2222 C  CG   . HIS A 1 181 ? 4.81500  18.20700  19.39400 1.000 30.68088  ? 181 HIS A CG   1 
ATOM   2223 N  ND1  . HIS A 1 181 ? 5.03800  17.76800  18.10800 1.000 34.59261  ? 181 HIS A ND1  1 
ATOM   2224 C  CD2  . HIS A 1 181 ? 6.01000  18.64700  19.85400 1.000 34.54096  ? 181 HIS A CD2  1 
ATOM   2225 C  CE1  . HIS A 1 181 ? 6.30900  17.95000  17.79700 1.000 39.04324  ? 181 HIS A CE1  1 
ATOM   2226 N  NE2  . HIS A 1 181 ? 6.92200  18.47700  18.84100 1.000 38.82609  ? 181 HIS A NE2  1 
ATOM   2227 H  H    . HIS A 1 181 ? 4.54400  16.84900  21.81700 1.000 36.63745  ? 181 HIS A H    1 
ATOM   2228 H  HA   . HIS A 1 181 ? 3.91700  19.36900  21.62900 1.000 37.15769  ? 181 HIS A HA   1 
ATOM   2229 H  HB2  . HIS A 1 181 ? 3.14100  17.23300  19.95100 1.000 40.53475  ? 181 HIS A HB2  1 
ATOM   2230 H  HB3  . HIS A 1 181 ? 2.88600  18.75800  19.58300 1.000 40.53475  ? 181 HIS A HB3  1 
ATOM   2231 H  HD2  . HIS A 1 181 ? 6.18100  18.99800  20.69800 1.000 41.38891  ? 181 HIS A HD2  1 
ATOM   2232 H  HE1  . HIS A 1 181 ? 6.70500  17.74300  16.98100 1.000 46.79165  ? 181 HIS A HE1  1 
ATOM   2233 H  HE2  . HIS A 1 181 ? 7.75700  18.68000  18.88100 1.000 46.53107  ? 181 HIS A HE2  1 
ATOM   2234 N  N    . SER A 1 182 ? 1.46200  17.46900  22.41400 1.000 35.81244  ? 182 SER A N    1 
ATOM   2235 C  CA   . SER A 1 182 ? 0.10100  17.49500  22.94100 1.000 45.34879  ? 182 SER A CA   1 
ATOM   2236 C  C    . SER A 1 182 ? 0.02400  18.27600  24.24600 1.000 46.39265  ? 182 SER A C    1 
ATOM   2237 O  O    . SER A 1 182 ? -1.02000 18.86000  24.56000 1.000 44.73760  ? 182 SER A O    1 
ATOM   2238 C  CB   . SER A 1 182 ? -0.40800 16.06800  23.14500 1.000 46.58484  ? 182 SER A CB   1 
ATOM   2239 O  OG   . SER A 1 182 ? 0.20600  15.46400  24.27200 1.000 51.58861  ? 182 SER A OG   1 
ATOM   2240 H  H    . SER A 1 182 ? 1.81000  16.68500  22.35600 1.000 42.91469  ? 182 SER A H    1 
ATOM   2241 H  HA   . SER A 1 182 ? -0.47700 17.93000  22.29500 1.000 54.35831  ? 182 SER A HA   1 
ATOM   2242 H  HB2  . SER A 1 182 ? -1.36800 16.09300  23.28500 1.000 55.84157  ? 182 SER A HB2  1 
ATOM   2243 H  HB3  . SER A 1 182 ? -0.20200 15.54400  22.35600 1.000 55.84157  ? 182 SER A HB3  1 
ATOM   2244 H  HG   . SER A 1 182 ? 1.04100  15.48100  24.18700 1.000 61.84609  ? 182 SER A HG   1 
ATOM   2245 N  N    . ALA A 1 183 ? 1.10900  18.29700  25.01700 1.000 40.31095  ? 183 ALA A N    1 
ATOM   2246 C  CA   . ALA A 1 183 ? 1.18000  19.07800  26.24300 1.000 43.82359  ? 183 ALA A CA   1 
ATOM   2247 C  C    . ALA A 1 183 ? 1.62700  20.51400  25.99600 1.000 37.34467  ? 183 ALA A C    1 
ATOM   2248 O  O    . ALA A 1 183 ? 1.89900  21.23800  26.95700 1.000 43.68458  ? 183 ALA A O    1 
ATOM   2249 C  CB   . ALA A 1 183 ? 2.12900  18.40800  27.24100 1.000 42.46198  ? 183 ALA A CB   1 
ATOM   2250 H  H    . ALA A 1 183 ? 1.82800  17.85900  24.84500 1.000 48.31290  ? 183 ALA A H    1 
ATOM   2251 H  HA   . ALA A 1 183 ? 0.29700  19.10400  26.64300 1.000 52.52807  ? 183 ALA A HA   1 
ATOM   2252 H  HB1  . ALA A 1 183 ? 2.11500  18.90500  28.07300 1.000 50.89414  ? 183 ALA A HB1  1 
ATOM   2253 H  HB2  . ALA A 1 183 ? 1.83300  17.49700  27.39500 1.000 50.89414  ? 183 ALA A HB2  1 
ATOM   2254 H  HB3  . ALA A 1 183 ? 3.02600  18.40600  26.87100 1.000 50.89414  ? 183 ALA A HB3  1 
ATOM   2255 N  N    . GLY A 1 184 ? 1.71000  20.93800  24.73600 1.000 37.39842  ? 184 GLY A N    1 
ATOM   2256 C  CA   . GLY A 1 184 ? 2.13500  22.28700  24.42300 1.000 44.57527  ? 184 GLY A CA   1 
ATOM   2257 C  C    . GLY A 1 184 ? 3.62800  22.50300  24.45300 1.000 48.51440  ? 184 GLY A C    1 
ATOM   2258 O  O    . GLY A 1 184 ? 4.07500  23.65200  24.53500 1.000 36.91309  ? 184 GLY A O    1 
ATOM   2259 H  H    . GLY A 1 184 ? 1.52400  20.45800  24.04700 1.000 44.81786  ? 184 GLY A H    1 
ATOM   2260 H  HA2  . GLY A 1 184 ? 1.82000  22.51300  23.53400 1.000 53.43008  ? 184 GLY A HA2  1 
ATOM   2261 H  HA3  . GLY A 1 184 ? 1.73400  22.89500  25.06400 1.000 53.43008  ? 184 GLY A HA3  1 
ATOM   2262 N  N    . ILE A 1 185 ? 4.41800  21.43700  24.38200 1.000 36.76589  ? 185 ILE A N    1 
ATOM   2263 C  CA   . ILE A 1 185 ? 5.87000  21.51500  24.48700 1.000 29.36686  ? 185 ILE A CA   1 
ATOM   2264 C  C    . ILE A 1 185 ? 6.45600  21.17200  23.12500 1.000 32.61399  ? 185 ILE A C    1 
ATOM   2265 O  O    . ILE A 1 185 ? 6.34800  20.02900  22.66300 1.000 30.73136  ? 185 ILE A O    1 
ATOM   2266 C  CB   . ILE A 1 185 ? 6.41300  20.57400  25.57200 1.000 30.57735  ? 185 ILE A CB   1 
ATOM   2267 C  CG1  . ILE A 1 185 ? 5.83600  20.94400  26.94000 1.000 38.71092  ? 185 ILE A CG1  1 
ATOM   2268 C  CG2  . ILE A 1 185 ? 7.93500  20.62600  25.61100 1.000 31.28278  ? 185 ILE A CG2  1 
ATOM   2269 C  CD1  . ILE A 1 185 ? 6.02400  19.86600  27.99200 1.000 37.57863  ? 185 ILE A CD1  1 
ATOM   2270 H  H    . ILE A 1 185 ? 4.12700  20.63600  24.26900 1.000 44.05883  ? 185 ILE A H    1 
ATOM   2271 H  HA   . ILE A 1 185 ? 6.12300  22.42500  24.70800 1.000 35.17999  ? 185 ILE A HA   1 
ATOM   2272 H  HB   . ILE A 1 185 ? 6.13800  19.67000  25.35300 1.000 36.63259  ? 185 ILE A HB   1 
ATOM   2273 H  HG12 . ILE A 1 185 ? 6.27600  21.74800  27.25800 1.000 46.39287  ? 185 ILE A HG12 1 
ATOM   2274 H  HG13 . ILE A 1 185 ? 4.88400  21.10200  26.84500 1.000 46.39287  ? 185 ILE A HG13 1 
ATOM   2275 H  HG21 . ILE A 1 185 ? 8.24600  20.16900  26.40800 1.000 37.47910  ? 185 ILE A HG21 1 
ATOM   2276 H  HG22 . ILE A 1 185 ? 8.28600  20.18900  24.82000 1.000 37.47910  ? 185 ILE A HG22 1 
ATOM   2277 H  HG23 . ILE A 1 185 ? 8.21900  21.55400  25.63000 1.000 37.47910  ? 185 ILE A HG23 1 
ATOM   2278 H  HD11 . ILE A 1 185 ? 5.38400  20.00800  28.70800 1.000 45.03412  ? 185 ILE A HD11 1 
ATOM   2279 H  HD12 . ILE A 1 185 ? 5.87600  18.99800  27.58500 1.000 45.03412  ? 185 ILE A HD12 1 
ATOM   2280 H  HD13 . ILE A 1 185 ? 6.92700  19.91900  28.34000 1.000 45.03412  ? 185 ILE A HD13 1 
ATOM   2281 N  N    . ILE A 1 186 ? 7.07400  22.15600  22.48100 1.000 31.62495  ? 186 ILE A N    1 
ATOM   2282 C  CA   . ILE A 1 186 ? 7.84900  21.94000  21.26500 1.000 31.17478  ? 186 ILE A CA   1 
ATOM   2283 C  C    . ILE A 1 186 ? 9.32100  21.99500  21.65100 1.000 37.12029  ? 186 ILE A C    1 
ATOM   2284 O  O    . ILE A 1 186 ? 9.79500  23.00000  22.19700 1.000 35.96786  ? 186 ILE A O    1 
ATOM   2285 C  CB   . ILE A 1 186 ? 7.50300  22.96900  20.17900 1.000 33.57062  ? 186 ILE A CB   1 
ATOM   2286 C  CG1  . ILE A 1 186 ? 6.05500  22.77300  19.71900 1.000 37.68763  ? 186 ILE A CG1  1 
ATOM   2287 C  CG2  . ILE A 1 186 ? 8.45000  22.83300  18.99300 1.000 31.94460  ? 186 ILE A CG2  1 
ATOM   2288 C  CD1  . ILE A 1 186 ? 5.48800  23.93100  18.92000 1.000 41.81624  ? 186 ILE A CD1  1 
ATOM   2289 H  H    . ILE A 1 186 ? 7.05800  22.97800  22.73600 1.000 37.88971  ? 186 ILE A H    1 
ATOM   2290 H  HA   . ILE A 1 186 ? 7.65800  21.06100  20.90200 1.000 37.34950  ? 186 ILE A HA   1 
ATOM   2291 H  HB   . ILE A 1 186 ? 7.60200  23.85900  20.55400 1.000 40.22450  ? 186 ILE A HB   1 
ATOM   2292 H  HG12 . ILE A 1 186 ? 6.01200  21.98200  19.15900 1.000 45.16492  ? 186 ILE A HG12 1 
ATOM   2293 H  HG13 . ILE A 1 186 ? 5.49500  22.65600  20.50300 1.000 45.16492  ? 186 ILE A HG13 1 
ATOM   2294 H  HG21 . ILE A 1 186 ? 8.12500  23.38400  18.26400 1.000 38.27328  ? 186 ILE A HG21 1 
ATOM   2295 H  HG22 . ILE A 1 186 ? 9.33500  23.12500  19.26000 1.000 38.27328  ? 186 ILE A HG22 1 
ATOM   2296 H  HG23 . ILE A 1 186 ? 8.47800  21.90300  18.71700 1.000 38.27328  ? 186 ILE A HG23 1 
ATOM   2297 H  HD11 . ILE A 1 186 ? 4.54900  23.76300  18.74400 1.000 50.11925  ? 186 ILE A HD11 1 
ATOM   2298 H  HD12 . ILE A 1 186 ? 5.58700  24.74800  19.43400 1.000 50.11925  ? 186 ILE A HD12 1 
ATOM   2299 H  HD13 . ILE A 1 186 ? 5.97300  24.00500  18.08400 1.000 50.11925  ? 186 ILE A HD13 1 
ATOM   2300 N  N    . HIS A 1 187 ? 10.04000 20.90800  21.36600 1.000 29.92360  ? 187 HIS A N    1 
ATOM   2301 C  CA   . HIS A 1 187 ? 11.36800 20.69500  21.93300 1.000 26.34344  ? 187 HIS A CA   1 
ATOM   2302 C  C    . HIS A 1 187 ? 12.40200 21.63000  21.31700 1.000 25.85808  ? 187 HIS A C    1 
ATOM   2303 O  O    . HIS A 1 187 ? 13.00000 22.45900  22.01400 1.000 25.12553  ? 187 HIS A O    1 
ATOM   2304 C  CB   . HIS A 1 187 ? 11.76600 19.23000  21.72900 1.000 27.30070  ? 187 HIS A CB   1 
ATOM   2305 C  CG   . HIS A 1 187 ? 12.86600 18.76700  22.62700 1.000 26.59356  ? 187 HIS A CG   1 
ATOM   2306 N  ND1  . HIS A 1 187 ? 14.17200 19.17900  22.47600 1.000 23.73969  ? 187 HIS A ND1  1 
ATOM   2307 C  CD2  . HIS A 1 187 ? 12.85800 17.91700  23.68100 1.000 23.62196  ? 187 HIS A CD2  1 
ATOM   2308 C  CE1  . HIS A 1 187 ? 14.92000 18.60600  23.40300 1.000 30.26645  ? 187 HIS A CE1  1 
ATOM   2309 N  NE2  . HIS A 1 187 ? 14.14600 17.83700  24.14600 1.000 24.16424  ? 187 HIS A NE2  1 
ATOM   2310 H  H    . HIS A 1 187 ? 9.77900  20.27500  20.84500 1.000 35.84808  ? 187 HIS A H    1 
ATOM   2311 H  HA   . HIS A 1 187 ? 11.34200 20.88600  22.88400 1.000 31.55189  ? 187 HIS A HA   1 
ATOM   2312 H  HB2  . HIS A 1 187 ? 10.99200 18.67100  21.89900 1.000 32.70061  ? 187 HIS A HB2  1 
ATOM   2313 H  HB3  . HIS A 1 187 ? 12.06500 19.11400  20.81300 1.000 32.70061  ? 187 HIS A HB3  1 
ATOM   2314 H  HD2  . HIS A 1 187 ? 12.11800 17.47100  24.02500 1.000 28.28611  ? 187 HIS A HD2  1 
ATOM   2315 H  HE1  . HIS A 1 187 ? 15.83600 18.72500  23.51300 1.000 36.25950  ? 187 HIS A HE1  1 
ATOM   2316 H  HE2  . HIS A 1 187 ? 14.40800 17.36200  24.81300 1.000 28.93685  ? 187 HIS A HE2  1 
ATOM   2317 N  N    . ARG A 1 188 ? 12.65300 21.48500  20.01600 1.000 25.77427  ? 188 ARG A N    1 
ATOM   2318 C  CA   . ARG A 1 188 ? 13.53800 22.28900  19.18000 1.000 25.43279  ? 188 ARG A CA   1 
ATOM   2319 C  C    . ARG A 1 188 ? 15.01600 21.94800  19.35700 1.000 25.03565  ? 188 ARG A C    1 
ATOM   2320 O  O    . ARG A 1 188 ? 15.83700 22.46900  18.60400 1.000 34.15893  ? 188 ARG A O    1 
ATOM   2321 C  CB   . ARG A 1 188 ? 13.37500 23.80800  19.40100 1.000 27.83711  ? 188 ARG A CB   1 
ATOM   2322 C  CG   . ARG A 1 188 ? 12.13100 24.40200  18.78300 1.000 29.21486  ? 188 ARG A CG   1 
ATOM   2323 C  CD   . ARG A 1 188 ? 12.12500 25.91000  18.94400 1.000 39.31688  ? 188 ARG A CD   1 
ATOM   2324 N  NE   . ARG A 1 188 ? 11.72000 26.31400  20.28400 1.000 38.05011  ? 188 ARG A NE   1 
ATOM   2325 C  CZ   . ARG A 1 188 ? 12.11000 27.43200  20.88700 1.000 56.20017  ? 188 ARG A CZ   1 
ATOM   2326 N  NH1  . ARG A 1 188 ? 12.91700 28.29600  20.29200 1.000 48.89399  ? 188 ARG A NH1  1 
ATOM   2327 N  NH2  . ARG A 1 188 ? 11.68000 27.68700  22.12000 1.000 51.11984  ? 188 ARG A NH2  1 
ATOM   2328 H  H    . ARG A 1 188 ? 12.28200 20.86100  19.55500 1.000 30.86889  ? 188 ARG A H    1 
ATOM   2329 H  HA   . ARG A 1 188 ? 13.30400 22.08800  18.26000 1.000 30.45911  ? 188 ARG A HA   1 
ATOM   2330 H  HB2  . ARG A 1 188 ? 13.33800 23.97900  20.35500 1.000 33.34429  ? 188 ARG A HB2  1 
ATOM   2331 H  HB3  . ARG A 1 188 ? 14.14000 24.26000  19.01200 1.000 33.34429  ? 188 ARG A HB3  1 
ATOM   2332 H  HG2  . ARG A 1 188 ? 12.10700 24.19200  17.83600 1.000 34.99759  ? 188 ARG A HG2  1 
ATOM   2333 H  HG3  . ARG A 1 188 ? 11.34600 24.04100  19.22300 1.000 34.99759  ? 188 ARG A HG3  1 
ATOM   2334 H  HD2  . ARG A 1 188 ? 13.01900 26.25200  18.78100 1.000 47.12001  ? 188 ARG A HD2  1 
ATOM   2335 H  HD3  . ARG A 1 188 ? 11.50200 26.29600  18.30900 1.000 47.12001  ? 188 ARG A HD3  1 
ATOM   2336 H  HE   . ARG A 1 188 ? 11.19000 25.79200  20.71600 1.000 45.59989  ? 188 ARG A HE   1 
ATOM   2337 H  HH11 . ARG A 1 188 ? 13.20200 28.14000  19.49600 1.000 58.61255  ? 188 ARG A HH11 1 
ATOM   2338 H  HH12 . ARG A 1 188 ? 13.15700 29.01300  20.70200 1.000 58.61255  ? 188 ARG A HH12 1 
ATOM   2339 H  HH21 . ARG A 1 188 ? 11.15600 27.13200  22.51600 1.000 61.28356  ? 188 ARG A HH21 1 
ATOM   2340 H  HH22 . ARG A 1 188 ? 11.92600 28.40700  22.52000 1.000 61.28356  ? 188 ARG A HH22 1 
ATOM   2341 N  N    . ASP A 1 189 ? 15.39700 21.11100  20.32100 1.000 27.92070  ? 189 ASP A N    1 
ATOM   2342 C  CA   . ASP A 1 189 ? 16.80200 20.76000  20.50000 1.000 26.14857  ? 189 ASP A CA   1 
ATOM   2343 C  C    . ASP A 1 189 ? 16.94700 19.28300  20.83200 1.000 25.59206  ? 189 ASP A C    1 
ATOM   2344 O  O    . ASP A 1 189 ? 17.73200 18.89600  21.70400 1.000 19.22151  ? 189 ASP A O    1 
ATOM   2345 C  CB   . ASP A 1 189 ? 17.45900 21.61200  21.58500 1.000 30.00480  ? 189 ASP A CB   1 
ATOM   2346 C  CG   . ASP A 1 189 ? 18.97100 21.64600  21.46000 1.000 32.08963  ? 189 ASP A CG   1 
ATOM   2347 O  OD1  . ASP A 1 189 ? 19.48500 21.36200  20.35400 1.000 30.36911  ? 189 ASP A OD1  1 
ATOM   2348 O  OD2  . ASP A 1 189 ? 19.64800 21.95300  22.46100 1.000 26.36363  ? 189 ASP A OD2  1 
ATOM   2349 H  H    . ASP A 1 189 ? 14.86100 20.73600  20.88000 1.000 33.44460  ? 189 ASP A H    1 
ATOM   2350 H  HA   . ASP A 1 189 ? 17.26200 20.92700  19.66300 1.000 31.31805  ? 189 ASP A HA   1 
ATOM   2351 H  HB2  . ASP A 1 189 ? 17.13100 22.52200  21.51600 1.000 35.94552  ? 189 ASP A HB2  1 
ATOM   2352 H  HB3  . ASP A 1 189 ? 17.23700 21.24500  22.45500 1.000 35.94552  ? 189 ASP A HB3  1 
ATOM   2353 N  N    . LEU A 1 190 ? 16.19500 18.43800  20.13500 1.000 21.97729  ? 190 LEU A N    1 
ATOM   2354 C  CA   . LEU A 1 190 ? 16.31000 16.99900  20.33300 1.000 21.69911  ? 190 LEU A CA   1 
ATOM   2355 C  C    . LEU A 1 190 ? 17.64300 16.51200  19.78100 1.000 26.00949  ? 190 LEU A C    1 
ATOM   2356 O  O    . LEU A 1 190 ? 18.01900 16.85400  18.65400 1.000 28.56765  ? 190 LEU A O    1 
ATOM   2357 C  CB   . LEU A 1 190 ? 15.15000 16.28100  19.64400 1.000 25.19311  ? 190 LEU A CB   1 
ATOM   2358 C  CG   . LEU A 1 190 ? 14.95600 14.81100  20.00800 1.000 33.82048  ? 190 LEU A CG   1 
ATOM   2359 C  CD1  . LEU A 1 190 ? 14.37700 14.70000  21.41000 1.000 30.70705  ? 190 LEU A CD1  1 
ATOM   2360 C  CD2  . LEU A 1 190 ? 14.06400 14.11000  18.99400 1.000 40.27577  ? 190 LEU A CD2  1 
ATOM   2361 H  H    . LEU A 1 190 ? 15.61400 18.67100  19.54500 1.000 26.31251  ? 190 LEU A H    1 
ATOM   2362 H  HA   . LEU A 1 190 ? 16.27100 16.78900  21.27900 1.000 25.97869  ? 190 LEU A HA   1 
ATOM   2363 H  HB2  . LEU A 1 190 ? 14.32900 16.74400  19.87300 1.000 30.17149  ? 190 LEU A HB2  1 
ATOM   2364 H  HB3  . LEU A 1 190 ? 15.29700 16.32200  18.68600 1.000 30.17149  ? 190 LEU A HB3  1 
ATOM   2365 H  HG   . LEU A 1 190 ? 15.81500 14.36100  19.99400 1.000 40.52434  ? 190 LEU A HG   1 
ATOM   2366 H  HD11 . LEU A 1 190 ? 14.19900 13.76700  21.60500 1.000 36.78822  ? 190 LEU A HD11 1 
ATOM   2367 H  HD12 . LEU A 1 190 ? 15.01800 15.05500  22.04500 1.000 36.78822  ? 190 LEU A HD12 1 
ATOM   2368 H  HD13 . LEU A 1 190 ? 13.55200 15.21000  21.45200 1.000 36.78822  ? 190 LEU A HD13 1 
ATOM   2369 H  HD21 . LEU A 1 190 ? 13.76100 13.26800  19.36900 1.000 48.27068  ? 190 LEU A HD21 1 
ATOM   2370 H  HD22 . LEU A 1 190 ? 13.30200 14.67800  18.79800 1.000 48.27068  ? 190 LEU A HD22 1 
ATOM   2371 H  HD23 . LEU A 1 190 ? 14.57300 13.94800  18.18500 1.000 48.27068  ? 190 LEU A HD23 1 
ATOM   2372 N  N    . LYS A 1 191 ? 18.35900 15.71400  20.56800 1.000 21.41073  ? 191 LYS A N    1 
ATOM   2373 C  CA   . LYS A 1 191 ? 19.66200 15.20900  20.16000 1.000 21.69108  ? 191 LYS A CA   1 
ATOM   2374 C  C    . LYS A 1 191 ? 19.92400 13.88500  20.86100 1.000 22.47887  ? 191 LYS A C    1 
ATOM   2375 O  O    . LYS A 1 191 ? 19.37100 13.62600  21.93700 1.000 25.06899  ? 191 LYS A O    1 
ATOM   2376 C  CB   . LYS A 1 191 ? 20.77400 16.21500  20.47900 1.000 24.97450  ? 191 LYS A CB   1 
ATOM   2377 C  CG   . LYS A 1 191 ? 20.96800 16.47500  21.95600 1.000 23.67637  ? 191 LYS A CG   1 
ATOM   2378 C  CD   . LYS A 1 191 ? 21.85000 17.69700  22.17800 1.000 32.99890  ? 191 LYS A CD   1 
ATOM   2379 C  CE   . LYS A 1 191 ? 21.03700 18.97900  22.07400 1.000 30.21431  ? 191 LYS A CE   1 
ATOM   2380 N  NZ   . LYS A 1 191 ? 21.82700 20.19700  22.41900 1.000 29.23453  ? 191 LYS A NZ   1 
ATOM   2381 H  H    . LYS A 1 191 ? 18.10900 15.45100  21.34800 1.000 25.63264  ? 191 LYS A H    1 
ATOM   2382 H  HA   . LYS A 1 191 ? 19.65800 15.04400  19.20400 1.000 25.96906  ? 191 LYS A HA   1 
ATOM   2383 H  HB2  . LYS A 1 191 ? 21.61100 15.87400  20.12700 1.000 29.90916  ? 191 LYS A HB2  1 
ATOM   2384 H  HB3  . LYS A 1 191 ? 20.55700 17.06100  20.05700 1.000 29.90916  ? 191 LYS A HB3  1 
ATOM   2385 H  HG2  . LYS A 1 191 ? 20.10800 16.63600  22.37300 1.000 28.35140  ? 191 LYS A HG2  1 
ATOM   2386 H  HG3  . LYS A 1 191 ? 21.39700 15.70800  22.36700 1.000 28.35140  ? 191 LYS A HG3  1 
ATOM   2387 H  HD2  . LYS A 1 191 ? 22.24500 17.65400  23.06300 1.000 39.53844  ? 191 LYS A HD2  1 
ATOM   2388 H  HD3  . LYS A 1 191 ? 22.54700 17.71900  21.50400 1.000 39.53844  ? 191 LYS A HD3  1 
ATOM   2389 H  HE2  . LYS A 1 191 ? 20.71800 19.07700  21.16400 1.000 36.19694  ? 191 LYS A HE2  1 
ATOM   2390 H  HE3  . LYS A 1 191 ? 20.28600 18.92700  22.68600 1.000 36.19694  ? 191 LYS A HE3  1 
ATOM   2391 H  HZ1  . LYS A 1 191 ? 21.30200 20.91500  22.40600 1.000 35.02119  ? 191 LYS A HZ1  1 
ATOM   2392 H  HZ2  . LYS A 1 191 ? 22.17900 20.11100  23.23300 1.000 35.02119  ? 191 LYS A HZ2  1 
ATOM   2393 H  HZ3  . LYS A 1 191 ? 22.48600 20.30900  21.83100 1.000 35.02119  ? 191 LYS A HZ3  1 
ATOM   2394 N  N    . PRO A 1 192 ? 20.77700 13.03100  20.28800 1.000 25.40410  ? 192 PRO A N    1 
ATOM   2395 C  CA   . PRO A 1 192 ? 20.95000 11.68100  20.85100 1.000 22.03166  ? 192 PRO A CA   1 
ATOM   2396 C  C    . PRO A 1 192 ? 21.52900 11.65400  22.25400 1.000 23.52570  ? 192 PRO A C    1 
ATOM   2397 O  O    . PRO A 1 192 ? 21.20100 10.74500  23.02300 1.000 21.76785  ? 192 PRO A O    1 
ATOM   2398 C  CB   . PRO A 1 192 ? 21.90100 10.99700  19.85400 1.000 25.92251  ? 192 PRO A CB   1 
ATOM   2399 C  CG   . PRO A 1 192 ? 21.86300 11.81400  18.62500 1.000 24.92604  ? 192 PRO A CG   1 
ATOM   2400 C  CD   . PRO A 1 192 ? 21.51100 13.21000  19.01900 1.000 29.94428  ? 192 PRO A CD   1 
ATOM   2401 H  HA   . PRO A 1 192 ? 20.09100 11.23100  20.85200 1.000 26.37776  ? 192 PRO A HA   1 
ATOM   2402 H  HB2  . PRO A 1 192 ? 22.79700 10.97400  20.22300 1.000 31.04678  ? 192 PRO A HB2  1 
ATOM   2403 H  HB3  . PRO A 1 192 ? 21.59200 10.09500  19.67600 1.000 31.04678  ? 192 PRO A HB3  1 
ATOM   2404 H  HG2  . PRO A 1 192 ? 22.73400 11.79300  18.20000 1.000 29.85101  ? 192 PRO A HG2  1 
ATOM   2405 H  HG3  . PRO A 1 192 ? 21.19200 11.45500  18.02300 1.000 29.85101  ? 192 PRO A HG3  1 
ATOM   2406 H  HD2  . PRO A 1 192 ? 22.31100 13.74100  19.15500 1.000 35.87289  ? 192 PRO A HD2  1 
ATOM   2407 H  HD3  . PRO A 1 192 ? 20.94600 13.62500  18.34900 1.000 35.87289  ? 192 PRO A HD3  1 
ATOM   2408 N  N    . SER A 1 193 ? 22.39200 12.60800  22.61000 1.000 23.00369  ? 193 SER A N    1 
ATOM   2409 C  CA   . SER A 1 193 ? 23.02600 12.57700  23.92300 1.000 29.17926  ? 193 SER A CA   1 
ATOM   2410 C  C    . SER A 1 193 ? 22.02200 12.71500  25.06300 1.000 23.97915  ? 193 SER A C    1 
ATOM   2411 O  O    . SER A 1 193 ? 22.34600 12.36200  26.20200 1.000 30.62091  ? 193 SER A O    1 
ATOM   2412 C  CB   . SER A 1 193 ? 24.07600 13.68400  24.01800 1.000 30.02668  ? 193 SER A CB   1 
ATOM   2413 O  OG   . SER A 1 193 ? 23.46400 14.95800  23.97600 1.000 26.76140  ? 193 SER A OG   1 
ATOM   2414 H  H    . SER A 1 193 ? 22.62200 13.27300  22.11600 1.000 27.54419  ? 193 SER A H    1 
ATOM   2415 H  HA   . SER A 1 193 ? 23.47400 11.72300  24.03000 1.000 34.95488  ? 193 SER A HA   1 
ATOM   2416 H  HB2  . SER A 1 193 ? 24.55800 13.59200  24.85400 1.000 35.97177  ? 193 SER A HB2  1 
ATOM   2417 H  HB3  . SER A 1 193 ? 24.69000 13.60300  23.27100 1.000 35.97177  ? 193 SER A HB3  1 
ATOM   2418 H  HG   . SER A 1 193 ? 24.02800 15.54100  23.75800 1.000 32.05344  ? 193 SER A HG   1 
ATOM   2419 N  N    . ASN A 1 194 ? 20.81600 13.21400  24.78800 1.000 21.70267  ? 194 ASN A N    1 
ATOM   2420 C  CA   . ASN A 1 194 ? 19.76500 13.33700  25.79000 1.000 23.70087  ? 194 ASN A CA   1 
ATOM   2421 C  C    . ASN A 1 194 ? 18.67700 12.28300  25.61400 1.000 24.64500  ? 194 ASN A C    1 
ATOM   2422 O  O    . ASN A 1 194 ? 17.54400 12.48000  26.06700 1.000 23.70986  ? 194 ASN A O    1 
ATOM   2423 C  CB   . ASN A 1 194 ? 19.16000 14.74100  25.74800 1.000 26.12082  ? 194 ASN A CB   1 
ATOM   2424 C  CG   . ASN A 1 194 ? 20.14700 15.80500  26.17600 1.000 31.70088  ? 194 ASN A CG   1 
ATOM   2425 O  OD1  . ASN A 1 194 ? 20.93500 15.59700  27.09400 1.000 29.86732  ? 194 ASN A OD1  1 
ATOM   2426 N  ND2  . ASN A 1 194 ? 20.11500 16.95000  25.50700 1.000 32.15694  ? 194 ASN A ND2  1 
ATOM   2427 H  H    . ASN A 1 194 ? 20.58100 13.49300  24.00900 1.000 25.98297  ? 194 ASN A H    1 
ATOM   2428 H  HA   . ASN A 1 194 ? 20.15800 13.20800  26.66700 1.000 28.38080  ? 194 ASN A HA   1 
ATOM   2429 H  HB2  . ASN A 1 194 ? 18.87700 14.93800  24.84100 1.000 31.28475  ? 194 ASN A HB2  1 
ATOM   2430 H  HB3  . ASN A 1 194 ? 18.39900 14.77600  26.34800 1.000 31.28475  ? 194 ASN A HB3  1 
ATOM   2431 H  HD21 . ASN A 1 194 ? 20.65700 17.58500  25.71400 1.000 38.52809  ? 194 ASN A HD21 1 
ATOM   2432 H  HD22 . ASN A 1 194 ? 19.55200 17.05700  24.86500 1.000 38.52809  ? 194 ASN A HD22 1 
ATOM   2433 N  N    . ILE A 1 195 ? 19.00300 11.17000  24.96500 1.000 17.08913  ? 195 ILE A N    1 
ATOM   2434 C  CA   . ILE A 1 195 ? 18.08900 10.05200  24.76900 1.000 19.26195  ? 195 ILE A CA   1 
ATOM   2435 C  C    . ILE A 1 195 ? 18.79800 8.80500   25.27800 1.000 22.60471  ? 195 ILE A C    1 
ATOM   2436 O  O    . ILE A 1 195 ? 19.97400 8.58800   24.96500 1.000 24.59491  ? 195 ILE A O    1 
ATOM   2437 C  CB   . ILE A 1 195 ? 17.68700 9.90100   23.28700 1.000 20.99357  ? 195 ILE A CB   1 
ATOM   2438 C  CG1  . ILE A 1 195 ? 17.03000 11.19500  22.78800 1.000 20.69159  ? 195 ILE A CG1  1 
ATOM   2439 C  CG2  . ILE A 1 195 ? 16.74300 8.71500   23.09500 1.000 24.34513  ? 195 ILE A CG2  1 
ATOM   2440 C  CD1  . ILE A 1 195 ? 16.66900 11.18800  21.30700 1.000 22.93329  ? 195 ILE A CD1  1 
ATOM   2441 H  H    . ILE A 1 195 ? 19.77700 11.03400  24.61700 1.000 20.44672  ? 195 ILE A H    1 
ATOM   2442 H  HA   . ILE A 1 195 ? 17.27600 10.18200  25.28100 1.000 23.05410  ? 195 ILE A HA   1 
ATOM   2443 H  HB   . ILE A 1 195 ? 18.49000 9.73300   22.76900 1.000 25.13204  ? 195 ILE A HB   1 
ATOM   2444 H  HG12 . ILE A 1 195 ? 16.21200 11.34000  23.28800 1.000 24.76968  ? 195 ILE A HG12 1 
ATOM   2445 H  HG13 . ILE A 1 195 ? 17.64500 11.93100  22.93600 1.000 24.76968  ? 195 ILE A HG13 1 
ATOM   2446 H  HG21 . ILE A 1 195 ? 16.50600 8.64800   22.15700 1.000 29.15391  ? 195 ILE A HG21 1 
ATOM   2447 H  HG22 . ILE A 1 195 ? 17.19300 7.90400   23.38000 1.000 29.15391  ? 195 ILE A HG22 1 
ATOM   2448 H  HG23 . ILE A 1 195 ? 15.94600 8.85600   23.62900 1.000 29.15391  ? 195 ILE A HG23 1 
ATOM   2449 H  HD11 . ILE A 1 195 ? 16.43100 12.08800  21.03500 1.000 27.45971  ? 195 ILE A HD11 1 
ATOM   2450 H  HD12 . ILE A 1 195 ? 17.43500 10.88000  20.79700 1.000 27.45971  ? 195 ILE A HD12 1 
ATOM   2451 H  HD13 . ILE A 1 195 ? 15.91800 10.59000  21.16800 1.000 27.45971  ? 195 ILE A HD13 1 
ATOM   2452 N  N    . VAL A 1 196 ? 18.09800 8.00300   26.08200 1.000 20.39777  ? 196 VAL A N    1 
ATOM   2453 C  CA   . VAL A 1 196 ? 18.68000 6.80800   26.67900 1.000 18.72551  ? 196 VAL A CA   1 
ATOM   2454 C  C    . VAL A 1 196 ? 17.82000 5.60500   26.32700 1.000 21.32845  ? 196 VAL A C    1 
ATOM   2455 O  O    . VAL A 1 196 ? 16.62300 5.72000   26.05100 1.000 22.46765  ? 196 VAL A O    1 
ATOM   2456 C  CB   . VAL A 1 196 ? 18.82900 6.93500   28.20900 1.000 23.90743  ? 196 VAL A CB   1 
ATOM   2457 C  CG1  . VAL A 1 196 ? 19.99300 7.84300   28.54700 1.000 23.90624  ? 196 VAL A CG1  1 
ATOM   2458 C  CG2  . VAL A 1 196 ? 17.54200 7.45800   28.82400 1.000 22.79734  ? 196 VAL A CG2  1 
ATOM   2459 H  H    . VAL A 1 196 ? 17.27600 8.13500   26.29700 1.000 24.41708  ? 196 VAL A H    1 
ATOM   2460 H  HA   . VAL A 1 196 ? 19.56000 6.66800   26.29700 1.000 22.41037  ? 196 VAL A HA   1 
ATOM   2461 H  HB   . VAL A 1 196 ? 19.00700 6.05900   28.58600 1.000 28.62868  ? 196 VAL A HB   1 
ATOM   2462 H  HG11 . VAL A 1 196 ? 20.10300 7.87000   29.51100 1.000 28.62726  ? 196 VAL A HG11 1 
ATOM   2463 H  HG12 . VAL A 1 196 ? 20.79700 7.49300   28.13300 1.000 28.62726  ? 196 VAL A HG12 1 
ATOM   2464 H  HG13 . VAL A 1 196 ? 19.80700 8.73300   28.21000 1.000 28.62726  ? 196 VAL A HG13 1 
ATOM   2465 H  HG21 . VAL A 1 196 ? 17.61800 7.42300   29.79000 1.000 27.29657  ? 196 VAL A HG21 1 
ATOM   2466 H  HG22 . VAL A 1 196 ? 17.40400 8.37300   28.53500 1.000 27.29657  ? 196 VAL A HG22 1 
ATOM   2467 H  HG23 . VAL A 1 196 ? 16.80300 6.90200   28.53000 1.000 27.29657  ? 196 VAL A HG23 1 
ATOM   2468 N  N    . VAL A 1 197 ? 18.45000 4.42800   26.36700 1.000 24.45200  ? 197 VAL A N    1 
ATOM   2469 C  CA   . VAL A 1 197 ? 17.86500 3.19600   25.85800 1.000 25.72782  ? 197 VAL A CA   1 
ATOM   2470 C  C    . VAL A 1 197 ? 18.17900 2.05200   26.81200 1.000 21.29175  ? 197 VAL A C    1 
ATOM   2471 O  O    . VAL A 1 197 ? 19.23000 2.02500   27.45700 1.000 24.93529  ? 197 VAL A O    1 
ATOM   2472 C  CB   . VAL A 1 197 ? 18.40100 2.88000   24.43900 1.000 21.79421  ? 197 VAL A CB   1 
ATOM   2473 C  CG1  . VAL A 1 197 ? 17.95700 1.50900   23.97300 1.000 35.95256  ? 197 VAL A CG1  1 
ATOM   2474 C  CG2  . VAL A 1 197 ? 17.96100 3.95900   23.45400 1.000 28.18045  ? 197 VAL A CG2  1 
ATOM   2475 H  H    . VAL A 1 197 ? 19.23800 4.32100   26.69400 1.000 29.28216  ? 197 VAL A H    1 
ATOM   2476 H  HA   . VAL A 1 197 ? 16.90000 3.28900   25.82300 1.000 30.81315  ? 197 VAL A HA   1 
ATOM   2477 H  HB   . VAL A 1 197 ? 19.37100 2.87200   24.47100 1.000 26.09282  ? 197 VAL A HB   1 
ATOM   2478 H  HG11 . VAL A 1 197 ? 18.29000 1.35700   23.07500 1.000 43.08283  ? 197 VAL A HG11 1 
ATOM   2479 H  HG12 . VAL A 1 197 ? 18.31500 0.83900   24.57600 1.000 43.08283  ? 197 VAL A HG12 1 
ATOM   2480 H  HG13 . VAL A 1 197 ? 16.98800 1.47300   23.97600 1.000 43.08283  ? 197 VAL A HG13 1 
ATOM   2481 H  HG21 . VAL A 1 197 ? 18.30500 3.74300   22.57300 1.000 33.75630  ? 197 VAL A HG21 1 
ATOM   2482 H  HG22 . VAL A 1 197 ? 16.99100 3.99000   23.43200 1.000 33.75630  ? 197 VAL A HG22 1 
ATOM   2483 H  HG23 . VAL A 1 197 ? 18.31200 4.81500   23.74500 1.000 33.75630  ? 197 VAL A HG23 1 
ATOM   2484 N  N    . LYS A 1 198 ? 17.26000 1.09500   26.88900 1.000 23.30922  ? 198 LYS A N    1 
ATOM   2485 C  CA   . LYS A 1 198 ? 17.48200 -0.15400  27.60500 1.000 26.18078  ? 198 LYS A CA   1 
ATOM   2486 C  C    . LYS A 1 198 ? 17.75100 -1.28900  26.62400 1.000 31.88430  ? 198 LYS A C    1 
ATOM   2487 O  O    . LYS A 1 198 ? 17.48000 -1.18800  25.42400 1.000 28.52493  ? 198 LYS A O    1 
ATOM   2488 C  CB   . LYS A 1 198 ? 16.28100 -0.49700  28.48900 1.000 32.56019  ? 198 LYS A CB   1 
ATOM   2489 C  CG   . LYS A 1 198 ? 16.25900 0.27400   29.79400 1.000 39.81471  ? 198 LYS A CG   1 
ATOM   2490 C  CD   . LYS A 1 198 ? 14.91600 0.18400   30.49600 1.000 47.13521  ? 198 LYS A CD   1 
ATOM   2491 C  CE   . LYS A 1 198 ? 14.68900 -1.18000  31.11700 1.000 61.21450  ? 198 LYS A CE   1 
ATOM   2492 N  NZ   . LYS A 1 198 ? 13.45300 -1.18800  31.94900 1.000 69.83616  ? 198 LYS A NZ   1 
ATOM   2493 H  H    . LYS A 1 198 ? 16.48200 1.14900   26.52500 1.000 27.91083  ? 198 LYS A H    1 
ATOM   2494 H  HA   . LYS A 1 198 ? 18.25800 -0.05800  28.17900 1.000 31.35669  ? 198 LYS A HA   1 
ATOM   2495 H  HB2  . LYS A 1 198 ? 15.46600 -0.28800  28.00600 1.000 39.01199  ? 198 LYS A HB2  1 
ATOM   2496 H  HB3  . LYS A 1 198 ? 16.30700 -1.44300  28.70100 1.000 39.01199  ? 198 LYS A HB3  1 
ATOM   2497 H  HG2  . LYS A 1 198 ? 16.93400 -0.08900  30.38800 1.000 47.71741  ? 198 LYS A HG2  1 
ATOM   2498 H  HG3  . LYS A 1 198 ? 16.44300 1.20900   29.61400 1.000 47.71741  ? 198 LYS A HG3  1 
ATOM   2499 H  HD2  . LYS A 1 198 ? 14.87900 0.84800   31.20200 1.000 56.50201  ? 198 LYS A HD2  1 
ATOM   2500 H  HD3  . LYS A 1 198 ? 14.20800 0.34400   29.85200 1.000 56.50201  ? 198 LYS A HD3  1 
ATOM   2501 H  HE2  . LYS A 1 198 ? 14.59100 -1.84300  30.41600 1.000 73.39716  ? 198 LYS A HE2  1 
ATOM   2502 H  HE3  . LYS A 1 198 ? 15.44200 -1.40600  31.68500 1.000 73.39716  ? 198 LYS A HE3  1 
ATOM   2503 H  HZ1  . LYS A 1 198 ? 13.32500 -1.99700  32.29800 1.000 83.74315  ? 198 LYS A HZ1  1 
ATOM   2504 H  HZ2  . LYS A 1 198 ? 13.52600 -0.59600  32.60900 1.000 83.74315  ? 198 LYS A HZ2  1 
ATOM   2505 H  HZ3  . LYS A 1 198 ? 12.74800 -0.97500  31.44800 1.000 83.74315  ? 198 LYS A HZ3  1 
ATOM   2506 N  N    . SER A 1 199 ? 18.29000 -2.38800  27.16100 1.000 30.68934  ? 199 SER A N    1 
ATOM   2507 C  CA   . SER A 1 199 ? 18.66500 -3.52200  26.32100 1.000 34.99113  ? 199 SER A CA   1 
ATOM   2508 C  C    . SER A 1 199 ? 17.47900 -4.06300  25.53400 1.000 32.37452  ? 199 SER A C    1 
ATOM   2509 O  O    . SER A 1 199 ? 17.66500 -4.64800  24.46100 1.000 39.19680  ? 199 SER A O    1 
ATOM   2510 C  CB   . SER A 1 199 ? 19.27900 -4.62700  27.18200 1.000 36.31460  ? 199 SER A CB   1 
ATOM   2511 O  OG   . SER A 1 199 ? 20.60800 -4.30000  27.54900 1.000 36.90321  ? 199 SER A OG   1 
ATOM   2512 H  H    . SER A 1 199 ? 18.44600 -2.50000  27.99900 1.000 36.76696  ? 199 SER A H    1 
ATOM   2513 H  HA   . SER A 1 199 ? 19.33200 -3.22700  25.68100 1.000 41.92912  ? 199 SER A HA   1 
ATOM   2514 H  HB2  . SER A 1 199 ? 18.74700 -4.73300  27.98600 1.000 43.51728  ? 199 SER A HB2  1 
ATOM   2515 H  HB3  . SER A 1 199 ? 19.28600 -5.45400  26.67700 1.000 43.51728  ? 199 SER A HB3  1 
ATOM   2516 H  HG   . SER A 1 199 ? 20.92300 -4.89700  28.05000 1.000 44.22362  ? 199 SER A HG   1 
ATOM   2517 N  N    . ASP A 1 200 ? 16.25800 -3.87600  26.03600 1.000 27.12574  ? 200 ASP A N    1 
ATOM   2518 C  CA   . ASP A 1 200 ? 15.06400 -4.35300  25.35000 1.000 30.61063  ? 200 ASP A CA   1 
ATOM   2519 C  C    . ASP A 1 200 ? 14.53900 -3.37800  24.28000 1.000 34.82366  ? 200 ASP A C    1 
ATOM   2520 O  O    . ASP A 1 200 ? 13.39100 -3.53400  23.84900 1.000 34.75613  ? 200 ASP A O    1 
ATOM   2521 C  CB   . ASP A 1 200 ? 13.95600 -4.65300  26.36700 1.000 32.90928  ? 200 ASP A CB   1 
ATOM   2522 C  CG   . ASP A 1 200 ? 13.47600 -3.41300  27.10200 1.000 42.58773  ? 200 ASP A CG   1 
ATOM   2523 O  OD1  . ASP A 1 200 ? 13.91300 -2.29400  26.75800 1.000 33.55294  ? 200 ASP A OD1  1 
ATOM   2524 O  OD2  . ASP A 1 200 ? 12.65300 -3.55900  28.03000 1.000 47.46479  ? 200 ASP A OD2  1 
ATOM   2525 H  H    . ASP A 1 200 ? 16.09800 -3.47300  26.77900 1.000 32.49065  ? 200 ASP A H    1 
ATOM   2526 H  HA   . ASP A 1 200 ? 15.29300 -5.18000  24.89900 1.000 36.67252  ? 200 ASP A HA   1 
ATOM   2527 H  HB2  . ASP A 1 200 ? 13.19700 -5.03800  25.90200 1.000 39.43090  ? 200 ASP A HB2  1 
ATOM   2528 H  HB3  . ASP A 1 200 ? 14.29400 -5.27900  27.02600 1.000 39.43090  ? 200 ASP A HB3  1 
ATOM   2529 N  N    . CYS A 1 201 ? 15.32400 -2.40600  23.82500 1.000 33.91736  ? 201 CYS A N    1 
ATOM   2530 C  CA   . CYS A 1 201 ? 14.92200 -1.44100  22.79100 1.000 35.70515  ? 201 CYS A CA   1 
ATOM   2531 C  C    . CYS A 1 201 ? 13.98400 -0.34200  23.27200 1.000 31.20699  ? 201 CYS A C    1 
ATOM   2532 O  O    . CYS A 1 201 ? 13.46100 0.39200   22.42600 1.000 34.91140  ? 201 CYS A O    1 
ATOM   2533 C  CB   . CYS A 1 201 ? 14.21100 -2.10900  21.60000 1.000 42.19980  ? 201 CYS A CB   1 
ATOM   2534 S  SG   . CYS A 1 201 ? 14.53200 -1.36400  19.96500 1.000 55.82157  ? 201 CYS A SG   1 
ATOM   2535 H  H    . CYS A 1 201 ? 16.12500 -2.27800  24.10900 1.000 40.64059  ? 201 CYS A H    1 
ATOM   2536 H  HA   . CYS A 1 201 ? 15.75100 -1.02400  22.50900 1.000 42.78594  ? 201 CYS A HA   1 
ATOM   2537 H  HB2  . CYS A 1 201 ? 14.49800 -3.03500  21.55500 1.000 50.57952  ? 201 CYS A HB2  1 
ATOM   2538 H  HB3  . CYS A 1 201 ? 13.25400 -2.06500  21.75300 1.000 50.57952  ? 201 CYS A HB3  1 
ATOM   2539 H  HG   . CYS A 1 201 ? 14.07600 -2.07800  19.11500 1.000 66.92564  ? 201 CYS A HG   1 
ATOM   2540 N  N    . THR A 1 202 ? 13.71200 -0.22200  24.56600 1.000 26.78670  ? 202 THR A N    1 
ATOM   2541 C  CA   . THR A 1 202 ? 12.83700 0.84400   25.02900 1.000 29.29317  ? 202 THR A CA   1 
ATOM   2542 C  C    . THR A 1 202 ? 13.66300 2.11000   25.21600 1.000 28.34418  ? 202 THR A C    1 
ATOM   2543 O  O    . THR A 1 202 ? 14.86900 2.05700   25.46800 1.000 27.63992  ? 202 THR A O    1 
ATOM   2544 C  CB   . THR A 1 202 ? 12.11100 0.43400   26.31200 1.000 38.73198  ? 202 THR A CB   1 
ATOM   2545 O  OG1  . THR A 1 202 ? 13.05600 0.05000   27.31600 1.000 36.31701  ? 202 THR A OG1  1 
ATOM   2546 C  CG2  . THR A 1 202 ? 11.18900 -0.74800  26.00500 1.000 40.28210  ? 202 THR A CG2  1 
ATOM   2547 H  H    . THR A 1 202 ? 14.01600 -0.73700  25.18500 1.000 32.08381  ? 202 THR A H    1 
ATOM   2548 H  HA   . THR A 1 202 ? 12.13900 1.03200   24.38200 1.000 35.09157  ? 202 THR A HA   1 
ATOM   2549 H  HB   . THR A 1 202 ? 11.58900 1.17800   26.65100 1.000 46.41814  ? 202 THR A HB   1 
ATOM   2550 H  HG1  . THR A 1 202 ? 13.47500 -0.63500  27.07000 1.000 43.52018  ? 202 THR A HG1  1 
ATOM   2551 H  HG21 . THR A 1 202 ? 10.78400 -1.07400  26.82300 1.000 48.27828  ? 202 THR A HG21 1 
ATOM   2552 H  HG22 . THR A 1 202 ? 10.48800 -0.47100  25.39500 1.000 48.27828  ? 202 THR A HG22 1 
ATOM   2553 H  HG23 . THR A 1 202 ? 11.69600 -1.46700  25.59600 1.000 48.27828  ? 202 THR A HG23 1 
ATOM   2554 N  N    . LEU A 1 203 ? 13.00800 3.25300   25.04700 1.000 29.11374  ? 203 LEU A N    1 
ATOM   2555 C  CA   . LEU A 1 203 ? 13.70200 4.51700   24.84600 1.000 27.08887  ? 203 LEU A CA   1 
ATOM   2556 C  C    . LEU A 1 203 ? 13.01900 5.61200   25.64700 1.000 23.39172  ? 203 LEU A C    1 
ATOM   2557 O  O    . LEU A 1 203 ? 11.80100 5.59200   25.83900 1.000 26.66184  ? 203 LEU A O    1 
ATOM   2558 C  CB   . LEU A 1 203 ? 13.72700 4.86100   23.34700 1.000 30.19855  ? 203 LEU A CB   1 
ATOM   2559 C  CG   . LEU A 1 203 ? 14.18700 6.23300   22.87200 1.000 25.73873  ? 203 LEU A CG   1 
ATOM   2560 C  CD1  . LEU A 1 203 ? 14.81900 6.08900   21.49600 1.000 30.92674  ? 203 LEU A CD1  1 
ATOM   2561 C  CD2  . LEU A 1 203 ? 13.02400 7.21000   22.82800 1.000 25.33465  ? 203 LEU A CD2  1 
ATOM   2562 H  H    . LEU A 1 203 ? 12.15100 3.32300   25.04500 1.000 34.87625  ? 203 LEU A H    1 
ATOM   2563 H  HA   . LEU A 1 203 ? 14.61400 4.46800   25.17200 1.000 32.44641  ? 203 LEU A HA   1 
ATOM   2564 H  HB2  . LEU A 1 203 ? 14.31500 4.21900   22.91900 1.000 36.17802  ? 203 LEU A HB2  1 
ATOM   2565 H  HB3  . LEU A 1 203 ? 12.82100 4.75300   23.01700 1.000 36.17802  ? 203 LEU A HB3  1 
ATOM   2566 H  HG   . LEU A 1 203 ? 14.84200 6.59500   23.48900 1.000 30.82624  ? 203 LEU A HG   1 
ATOM   2567 H  HD11 . LEU A 1 203 ? 14.99200 6.97200   21.13400 1.000 37.05185  ? 203 LEU A HD11 1 
ATOM   2568 H  HD12 . LEU A 1 203 ? 15.65100 5.59700   21.58100 1.000 37.05185  ? 203 LEU A HD12 1 
ATOM   2569 H  HD13 . LEU A 1 203 ? 14.20800 5.60700   20.91700 1.000 37.05185  ? 203 LEU A HD13 1 
ATOM   2570 H  HD21 . LEU A 1 203 ? 13.30900 8.02100   22.38100 1.000 30.34135  ? 203 LEU A HD21 1 
ATOM   2571 H  HD22 . LEU A 1 203 ? 12.28900 6.80400   22.34100 1.000 30.34135  ? 203 LEU A HD22 1 
ATOM   2572 H  HD23 . LEU A 1 203 ? 12.74700 7.41200   23.73600 1.000 30.34135  ? 203 LEU A HD23 1 
ATOM   2573 N  N    . LYS A 1 204 ? 13.81800 6.57400   26.11800 1.000 20.66333  ? 204 LYS A N    1 
ATOM   2574 C  CA   . LYS A 1 204 ? 13.29900 7.71600   26.85900 1.000 17.51101  ? 204 LYS A CA   1 
ATOM   2575 C  C    . LYS A 1 204 ? 14.04300 8.98200   26.45700 1.000 22.34218  ? 204 LYS A C    1 
ATOM   2576 O  O    . LYS A 1 204 ? 15.27200 8.98100   26.35500 1.000 23.13410  ? 204 LYS A O    1 
ATOM   2577 C  CB   . LYS A 1 204 ? 13.43500 7.51700   28.37700 1.000 22.19022  ? 204 LYS A CB   1 
ATOM   2578 C  CG   . LYS A 1 204 ? 12.53800 6.43800   28.96100 1.000 23.67626  ? 204 LYS A CG   1 
ATOM   2579 C  CD   . LYS A 1 204 ? 12.71300 6.36100   30.47900 1.000 25.98129  ? 204 LYS A CD   1 
ATOM   2580 C  CE   . LYS A 1 204 ? 12.03800 5.13000   31.06600 1.000 32.80297  ? 204 LYS A CE   1 
ATOM   2581 N  NZ   . LYS A 1 204 ? 10.57700 5.11800   30.78300 1.000 27.91821  ? 204 LYS A NZ   1 
ATOM   2582 H  H    . LYS A 1 204 ? 14.67200 6.58400   26.01700 1.000 24.73576  ? 204 LYS A H    1 
ATOM   2583 H  HA   . LYS A 1 204 ? 12.36100 7.82800   26.63800 1.000 20.95297  ? 204 LYS A HA   1 
ATOM   2584 H  HB2  . LYS A 1 204 ? 14.35300 7.27100   28.57300 1.000 26.56803  ? 204 LYS A HB2  1 
ATOM   2585 H  HB3  . LYS A 1 204 ? 13.21400 8.35100   28.81800 1.000 26.56803  ? 204 LYS A HB3  1 
ATOM   2586 H  HG2  . LYS A 1 204 ? 11.61000 6.64700   28.76700 1.000 28.35127  ? 204 LYS A HG2  1 
ATOM   2587 H  HG3  . LYS A 1 204 ? 12.77100 5.57800   28.57800 1.000 28.35127  ? 204 LYS A HG3  1 
ATOM   2588 H  HD2  . LYS A 1 204 ? 13.65900 6.31700   30.69000 1.000 31.11731  ? 204 LYS A HD2  1 
ATOM   2589 H  HD3  . LYS A 1 204 ? 12.31800 7.14700   30.88700 1.000 31.11731  ? 204 LYS A HD3  1 
ATOM   2590 H  HE2  . LYS A 1 204 ? 12.43000 4.33300   30.67700 1.000 39.30332  ? 204 LYS A HE2  1 
ATOM   2591 H  HE3  . LYS A 1 204 ? 12.16200 5.12500   32.02800 1.000 39.30332  ? 204 LYS A HE3  1 
ATOM   2592 H  HZ1  . LYS A 1 204 ? 10.43700 5.10400   29.90400 1.000 33.44161  ? 204 LYS A HZ1  1 
ATOM   2593 H  HZ2  . LYS A 1 204 ? 10.20200 4.39700   31.14600 1.000 33.44161  ? 204 LYS A HZ2  1 
ATOM   2594 H  HZ3  . LYS A 1 204 ? 10.19500 5.84600   31.12400 1.000 33.44161  ? 204 LYS A HZ3  1 
ATOM   2595 N  N    . ILE A 1 205 ? 13.28300 10.05500  26.23400 1.000 22.83409  ? 205 ILE A N    1 
ATOM   2596 C  CA   . ILE A 1 205 ? 13.83100 11.39200  26.02900 1.000 19.08479  ? 205 ILE A CA   1 
ATOM   2597 C  C    . ILE A 1 205 ? 13.96200 12.06200  27.39400 1.000 18.08138  ? 205 ILE A C    1 
ATOM   2598 O  O    . ILE A 1 205 ? 13.00700 12.07100  28.17700 1.000 25.94433  ? 205 ILE A O    1 
ATOM   2599 C  CB   . ILE A 1 205 ? 12.92500 12.21700  25.10100 1.000 23.56301  ? 205 ILE A CB   1 
ATOM   2600 C  CG1  . ILE A 1 205 ? 12.77800 11.54200  23.73200 1.000 23.71875  ? 205 ILE A CG1  1 
ATOM   2601 C  CG2  . ILE A 1 205 ? 13.46400 13.63700  24.95600 1.000 25.32010  ? 205 ILE A CG2  1 
ATOM   2602 C  CD1  . ILE A 1 205 ? 11.61500 12.08700  22.91500 1.000 23.46951  ? 205 ILE A CD1  1 
ATOM   2603 H  H    . ILE A 1 205 ? 12.42400 10.03200  26.19600 1.000 27.34067  ? 205 ILE A H    1 
ATOM   2604 H  HA   . ILE A 1 205 ? 14.71000 11.32800  25.62200 1.000 22.84151  ? 205 ILE A HA   1 
ATOM   2605 H  HB   . ILE A 1 205 ? 12.04400 12.26200  25.50300 1.000 28.21538  ? 205 ILE A HB   1 
ATOM   2606 H  HG12 . ILE A 1 205 ? 13.59100 11.68300  23.22300 1.000 28.40226  ? 205 ILE A HG12 1 
ATOM   2607 H  HG13 . ILE A 1 205 ? 12.62900 10.59300  23.86500 1.000 28.40226  ? 205 ILE A HG13 1 
ATOM   2608 H  HG21 . ILE A 1 205 ? 12.96500 14.09500  24.26100 1.000 30.32388  ? 205 ILE A HG21 1 
ATOM   2609 H  HG22 . ILE A 1 205 ? 13.35900 14.10300  25.80000 1.000 30.32388  ? 205 ILE A HG22 1 
ATOM   2610 H  HG23 . ILE A 1 205 ? 14.40300 13.59600  24.71500 1.000 30.32388  ? 205 ILE A HG23 1 
ATOM   2611 H  HD11 . ILE A 1 205 ? 11.50200 11.53900  22.12300 1.000 28.10317  ? 205 ILE A HD11 1 
ATOM   2612 H  HD12 . ILE A 1 205 ? 10.81000 12.06000  23.45500 1.000 28.10317  ? 205 ILE A HD12 1 
ATOM   2613 H  HD13 . ILE A 1 205 ? 11.81100 13.00200  22.65900 1.000 28.10317  ? 205 ILE A HD13 1 
ATOM   2614 N  N    . LEU A 1 206 ? 15.13100 12.64700  27.67200 1.000 22.19630  ? 206 LEU A N    1 
ATOM   2615 C  CA   . LEU A 1 206 ? 15.45400 13.11200  29.01800 1.000 20.77155  ? 206 LEU A CA   1 
ATOM   2616 C  C    . LEU A 1 206 ? 15.32200 14.62000  29.22800 1.000 27.30698  ? 206 LEU A C    1 
ATOM   2617 O  O    . LEU A 1 206 ? 15.42200 15.06800  30.37300 1.000 24.68218  ? 206 LEU A O    1 
ATOM   2618 C  CB   . LEU A 1 206 ? 16.88600 12.70200  29.39400 1.000 23.47470  ? 206 LEU A CB   1 
ATOM   2619 C  CG   . LEU A 1 206 ? 17.20900 11.20800  29.49300 1.000 28.53980  ? 206 LEU A CG   1 
ATOM   2620 C  CD1  . LEU A 1 206 ? 18.64200 11.01500  29.96800 1.000 29.32681  ? 206 LEU A CD1  1 
ATOM   2621 C  CD2  . LEU A 1 206 ? 16.24400 10.49700  30.42200 1.000 29.46161  ? 206 LEU A CD2  1 
ATOM   2622 H  H    . LEU A 1 206 ? 15.75400 12.78400  27.09400 1.000 26.57532  ? 206 LEU A H    1 
ATOM   2623 H  HA   . LEU A 1 206 ? 14.82800 12.68100  29.62100 1.000 24.86562  ? 206 LEU A HA   1 
ATOM   2624 H  HB2  . LEU A 1 206 ? 17.48200 13.07100  28.72400 1.000 28.10940  ? 206 LEU A HB2  1 
ATOM   2625 H  HB3  . LEU A 1 206 ? 17.08300 13.08600  30.26200 1.000 28.10940  ? 206 LEU A HB3  1 
ATOM   2626 H  HG   . LEU A 1 206 ? 17.11500 10.81000  28.61300 1.000 34.18752  ? 206 LEU A HG   1 
ATOM   2627 H  HD11 . LEU A 1 206 ? 18.81100 10.06600  30.08200 1.000 35.13194  ? 206 LEU A HD11 1 
ATOM   2628 H  HD12 . LEU A 1 206 ? 19.24700 11.38100  29.30400 1.000 35.13194  ? 206 LEU A HD12 1 
ATOM   2629 H  HD13 . LEU A 1 206 ? 18.75900 11.47600  30.81300 1.000 35.13194  ? 206 LEU A HD13 1 
ATOM   2630 H  HD21 . LEU A 1 206 ? 16.58800 9.61100   30.61600 1.000 35.29370  ? 206 LEU A HD21 1 
ATOM   2631 H  HD22 . LEU A 1 206 ? 16.16200 11.00700  31.24300 1.000 35.29370  ? 206 LEU A HD22 1 
ATOM   2632 H  HD23 . LEU A 1 206 ? 15.37900 10.42800  29.98700 1.000 35.29370  ? 206 LEU A HD23 1 
ATOM   2633 N  N    . ASP A 1 207 ? 15.11500 15.42100  28.18200 1.000 26.20391  ? 207 ASP A N    1 
ATOM   2634 C  CA   . ASP A 1 207 ? 15.06800 16.86800  28.35900 1.000 25.90083  ? 207 ASP A CA   1 
ATOM   2635 C  C    . ASP A 1 207 ? 13.90900 17.45500  27.56600 1.000 30.01342  ? 207 ASP A C    1 
ATOM   2636 O  O    . ASP A 1 207 ? 13.24900 16.76800  26.78300 1.000 24.28601  ? 207 ASP A O    1 
ATOM   2637 C  CB   . ASP A 1 207 ? 16.39900 17.52100  27.95900 1.000 28.34750  ? 207 ASP A CB   1 
ATOM   2638 C  CG   . ASP A 1 207 ? 16.51700 17.73600  26.46600 1.000 35.52739  ? 207 ASP A CG   1 
ATOM   2639 O  OD1  . ASP A 1 207 ? 16.20200 16.79600  25.70100 1.000 30.87645  ? 207 ASP A OD1  1 
ATOM   2640 O  OD2  . ASP A 1 207 ? 16.92600 18.84500  26.05800 1.000 35.89084  ? 207 ASP A OD2  1 
ATOM   2641 H  H    . ASP A 1 207 ? 15.00100 15.15100  27.37300 1.000 31.38446  ? 207 ASP A H    1 
ATOM   2642 H  HA   . ASP A 1 207 ? 14.90000 17.06400  29.29400 1.000 31.02076  ? 207 ASP A HA   1 
ATOM   2643 H  HB2  . ASP A 1 207 ? 16.47000 18.38500  28.39300 1.000 33.95676  ? 207 ASP A HB2  1 
ATOM   2644 H  HB3  . ASP A 1 207 ? 17.12900 16.94700  28.23900 1.000 33.95676  ? 207 ASP A HB3  1 
ATOM   2645 N  N    . PHE A 1 208 ? 13.66100 18.75300  27.78100 1.000 25.45478  ? 208 PHE A N    1 
ATOM   2646 C  CA   . PHE A 1 208 ? 12.48300 19.41200  27.22900 1.000 22.86903  ? 208 PHE A CA   1 
ATOM   2647 C  C    . PHE A 1 208 ? 12.81300 20.55000  26.27100 1.000 26.41531  ? 208 PHE A C    1 
ATOM   2648 O  O    . PHE A 1 208 ? 11.90300 21.28300  25.86800 1.000 29.50764  ? 208 PHE A O    1 
ATOM   2649 C  CB   . PHE A 1 208 ? 11.58900 19.92500  28.36400 1.000 28.63719  ? 208 PHE A CB   1 
ATOM   2650 C  CG   . PHE A 1 208 ? 11.06700 18.83500  29.25500 1.000 25.08824  ? 208 PHE A CG   1 
ATOM   2651 C  CD1  . PHE A 1 208 ? 9.94100  18.11300  28.90100 1.000 26.72028  ? 208 PHE A CD1  1 
ATOM   2652 C  CD2  . PHE A 1 208 ? 11.70300 18.53300  30.45000 1.000 33.10311  ? 208 PHE A CD2  1 
ATOM   2653 C  CE1  . PHE A 1 208 ? 9.45900  17.10300  29.71700 1.000 29.79851  ? 208 PHE A CE1  1 
ATOM   2654 C  CE2  . PHE A 1 208 ? 11.22300 17.52900  31.27300 1.000 36.49781  ? 208 PHE A CE2  1 
ATOM   2655 C  CZ   . PHE A 1 208 ? 10.10000 16.81400  30.90700 1.000 35.27524  ? 208 PHE A CZ   1 
ATOM   2656 H  H    . PHE A 1 208 ? 14.16500 19.27100  28.24700 1.000 30.48550  ? 208 PHE A H    1 
ATOM   2657 H  HA   . PHE A 1 208 ? 11.98500 18.75400  26.71900 1.000 27.38259  ? 208 PHE A HA   1 
ATOM   2658 H  HB2  . PHE A 1 208 ? 12.10200 20.53800  28.91300 1.000 34.30439  ? 208 PHE A HB2  1 
ATOM   2659 H  HB3  . PHE A 1 208 ? 10.82700 20.38300  27.97800 1.000 34.30439  ? 208 PHE A HB3  1 
ATOM   2660 H  HD1  . PHE A 1 208 ? 9.50200  18.30900  28.10500 1.000 32.00409  ? 208 PHE A HD1  1 
ATOM   2661 H  HD2  . PHE A 1 208 ? 12.46000 19.01100  30.70200 1.000 39.66350  ? 208 PHE A HD2  1 
ATOM   2662 H  HE1  . PHE A 1 208 ? 8.70600  16.62000  29.46500 1.000 35.69798  ? 208 PHE A HE1  1 
ATOM   2663 H  HE2  . PHE A 1 208 ? 11.65700 17.33600  32.07300 1.000 43.73713  ? 208 PHE A HE2  1 
ATOM   2664 H  HZ   . PHE A 1 208 ? 9.77500  16.14000  31.45900 1.000 42.27005  ? 208 PHE A HZ   1 
ATOM   2665 N  N    . GLY A 1 209 ? 14.07200 20.72000  25.89300 1.000 26.20950  ? 209 GLY A N    1 
ATOM   2666 C  CA   . GLY A 1 209 ? 14.40200 21.55700  24.75500 1.000 29.47757  ? 209 GLY A CA   1 
ATOM   2667 C  C    . GLY A 1 209 ? 14.70900 22.99700  25.11800 1.000 36.68912  ? 209 GLY A C    1 
ATOM   2668 O  O    . GLY A 1 209 ? 15.09500 23.33400  26.24000 1.000 26.02904  ? 209 GLY A O    1 
ATOM   2669 H  H    . GLY A 1 209 ? 14.75100 20.36000  26.28000 1.000 31.39117  ? 209 GLY A H    1 
ATOM   2670 H  HA2  . GLY A 1 209 ? 15.18000 21.18900  24.30800 1.000 35.31284  ? 209 GLY A HA2  1 
ATOM   2671 H  HA3  . GLY A 1 209 ? 13.65400 21.55700  24.13700 1.000 35.31284  ? 209 GLY A HA3  1 
ATOM   2672 N  N    . LEU A 1 210 ? 14.52300 23.86400  24.12300 1.000 25.30463  ? 210 LEU A N    1 
ATOM   2673 C  CA   . LEU A 1 210 ? 14.96100 25.24400  24.22500 1.000 36.16408  ? 210 LEU A CA   1 
ATOM   2674 C  C    . LEU A 1 210 ? 13.95700 26.09800  24.98600 1.000 39.39752  ? 210 LEU A C    1 
ATOM   2675 O  O    . LEU A 1 210 ? 12.76900 25.78000  25.08100 1.000 31.93290  ? 210 LEU A O    1 
ATOM   2676 C  CB   . LEU A 1 210 ? 15.15500 25.86600  22.84100 1.000 28.69370  ? 210 LEU A CB   1 
ATOM   2677 C  CG   . LEU A 1 210 ? 16.21800 25.24500  21.94400 1.000 33.44738  ? 210 LEU A CG   1 
ATOM   2678 C  CD1  . LEU A 1 210 ? 16.27000 25.98500  20.62000 1.000 38.49787  ? 210 LEU A CD1  1 
ATOM   2679 C  CD2  . LEU A 1 210 ? 17.56300 25.28100  22.65100 1.000 33.28581  ? 210 LEU A CD2  1 
ATOM   2680 H  H    . LEU A 1 210 ? 14.14300 23.67200  23.37600 1.000 30.30532  ? 210 LEU A H    1 
ATOM   2681 H  HA   . LEU A 1 210 ? 15.80500 25.24700  24.70300 1.000 43.33666  ? 210 LEU A HA   1 
ATOM   2682 H  HB2  . LEU A 1 210 ? 14.31200 25.80300  22.36600 1.000 34.37220  ? 210 LEU A HB2  1 
ATOM   2683 H  HB3  . LEU A 1 210 ? 15.39800 26.79700  22.96400 1.000 34.37220  ? 210 LEU A HB3  1 
ATOM   2684 H  HG   . LEU A 1 210 ? 16.00200 24.31800  21.75700 1.000 40.07662  ? 210 LEU A HG   1 
ATOM   2685 H  HD11 . LEU A 1 210 ? 16.86700 25.51300  20.01800 1.000 46.13720  ? 210 LEU A HD11 1 
ATOM   2686 H  HD12 . LEU A 1 210 ? 15.37800 26.01800  20.24100 1.000 46.13720  ? 210 LEU A HD12 1 
ATOM   2687 H  HD13 . LEU A 1 210 ? 16.59800 26.88500  20.77400 1.000 46.13720  ? 210 LEU A HD13 1 
ATOM   2688 H  HD21 . LEU A 1 210 ? 18.26000 25.05200  22.01600 1.000 39.88273  ? 210 LEU A HD21 1 
ATOM   2689 H  HD22 . LEU A 1 210 ? 17.71300 26.17400  22.99900 1.000 39.88273  ? 210 LEU A HD22 1 
ATOM   2690 H  HD23 . LEU A 1 210 ? 17.55500 24.63900  23.37800 1.000 39.88273  ? 210 LEU A HD23 1 
ATOM   2691 N  N    . ALA A 1 211 ? 14.44200 27.22700  25.48900 1.000 47.33375  ? 211 ALA A N    1 
ATOM   2692 C  CA   . ALA A 1 211 ? 13.55600 28.28200  25.95700 1.000 52.34648  ? 211 ALA A CA   1 
ATOM   2693 C  C    . ALA A 1 211 ? 13.11200 29.12500  24.77000 1.000 53.83946  ? 211 ALA A C    1 
ATOM   2694 O  O    . ALA A 1 211 ? 12.06600 28.86600  24.19100 1.000 53.22388  ? 211 ALA A O    1 
ATOM   2695 C  CB   . ALA A 1 211 ? 14.24400 29.13800  26.99200 1.000 55.24543  ? 211 ALA A CB   1 
ATOM   2696 H  H    . ALA A 1 211 ? 15.28000 27.40400  25.56900 1.000 56.74026  ? 211 ALA A H    1 
ATOM   2697 H  HA   . ALA A 1 211 ? 12.77600 27.89500  26.38400 1.000 62.75553  ? 211 ALA A HA   1 
ATOM   2698 H  HB1  . ALA A 1 211 ? 13.60700 29.77600  27.35000 1.000 66.23428  ? 211 ALA A HB1  1 
ATOM   2699 H  HB2  . ALA A 1 211 ? 14.57600 28.56800  27.70400 1.000 66.23428  ? 211 ALA A HB2  1 
ATOM   2700 H  HB3  . ALA A 1 211 ? 14.98200 29.60800  26.57300 1.000 66.23428  ? 211 ALA A HB3  1 
ATOM   2701 N  N    . SER A 1 217 ? 21.55900 33.45700  25.72500 1.000 63.27649  ? 217 SER A N    1 
ATOM   2702 C  CA   . SER A 1 217 ? 22.27000 32.65500  26.71200 1.000 70.32048  ? 217 SER A CA   1 
ATOM   2703 C  C    . SER A 1 217 ? 23.66600 33.20200  26.96800 1.000 74.26484  ? 217 SER A C    1 
ATOM   2704 O  O    . SER A 1 217 ? 24.00000 34.30800  26.54500 1.000 75.63781  ? 217 SER A O    1 
ATOM   2705 C  CB   . SER A 1 217 ? 22.38100 31.20100  26.24800 1.000 67.71591  ? 217 SER A CB   1 
ATOM   2706 O  OG   . SER A 1 217 ? 23.57600 31.00400  25.50900 1.000 73.36693  ? 217 SER A OG   1 
ATOM   2707 H  HA   . SER A 1 217 ? 21.77000 32.68000  27.54200 1.000 84.32433  ? 217 SER A HA   1 
ATOM   2708 H  HB2  . SER A 1 217 ? 22.38800 30.62000  27.02400 1.000 81.19886  ? 217 SER A HB2  1 
ATOM   2709 H  HB3  . SER A 1 217 ? 21.62100 30.99000  25.68300 1.000 81.19886  ? 217 SER A HB3  1 
ATOM   2710 H  HG   . SER A 1 217 ? 23.92600 30.27000  25.71900 1.000 87.98008  ? 217 SER A HG   1 
ATOM   2711 N  N    . PHE A 1 218 ? 24.46600 32.40500  27.67800 1.000 71.72818  ? 218 PHE A N    1 
ATOM   2712 C  CA   . PHE A 1 218 ? 25.90100 32.61600  27.81700 1.000 72.85798  ? 218 PHE A CA   1 
ATOM   2713 C  C    . PHE A 1 218 ? 26.44900 31.72000  28.92000 1.000 66.81407  ? 218 PHE A C    1 
ATOM   2714 O  O    . PHE A 1 218 ? 26.01200 31.80600  30.07400 1.000 49.94364  ? 218 PHE A O    1 
ATOM   2715 C  CB   . PHE A 1 218 ? 26.25500 34.06900  28.13300 1.000 70.83349  ? 218 PHE A CB   1 
ATOM   2716 C  CG   . PHE A 1 218 ? 27.66800 34.24600  28.61900 1.000 58.82961  ? 218 PHE A CG   1 
ATOM   2717 C  CD1  . PHE A 1 218 ? 28.73900 34.00800  27.77300 1.000 48.89325  ? 218 PHE A CD1  1 
ATOM   2718 C  CD2  . PHE A 1 218 ? 27.92800 34.63500  29.92300 1.000 55.62545  ? 218 PHE A CD2  1 
ATOM   2719 C  CE1  . PHE A 1 218 ? 30.04100 34.16100  28.21400 1.000 42.17937  ? 218 PHE A CE1  1 
ATOM   2720 C  CE2  . PHE A 1 218 ? 29.23000 34.79100  30.37000 1.000 43.16369  ? 218 PHE A CE2  1 
ATOM   2721 C  CZ   . PHE A 1 218 ? 30.28600 34.55500  29.51500 1.000 38.47163  ? 218 PHE A CZ   1 
ATOM   2722 H  H    . PHE A 1 218 ? 24.18900 31.71100  28.10300 1.000 86.01357  ? 218 PHE A H    1 
ATOM   2723 H  HA   . PHE A 1 218 ? 26.31600 32.39900  26.96700 1.000 87.36934  ? 218 PHE A HA   1 
ATOM   2724 H  HB2  . PHE A 1 218 ? 26.14800 34.59900  27.32800 1.000 84.93995  ? 218 PHE A HB2  1 
ATOM   2725 H  HB3  . PHE A 1 218 ? 25.65800 34.39300  28.82600 1.000 84.93995  ? 218 PHE A HB3  1 
ATOM   2726 H  HD1  . PHE A 1 218 ? 28.58000 33.74200  26.89600 1.000 58.61166  ? 218 PHE A HD1  1 
ATOM   2727 H  HD2  . PHE A 1 218 ? 27.22000 34.79400  30.50500 1.000 66.69030  ? 218 PHE A HD2  1 
ATOM   2728 H  HE1  . PHE A 1 218 ? 30.75000 34.00000  27.63400 1.000 50.55501  ? 218 PHE A HE1  1 
ATOM   2729 H  HE2  . PHE A 1 218 ? 29.39200 35.05500  31.24600 1.000 51.73619  ? 218 PHE A HE2  1 
ATOM   2730 H  HZ   . PHE A 1 218 ? 31.16100 34.66000  29.81300 1.000 46.10571  ? 218 PHE A HZ   1 
ATOM   2731 N  N    . MET A 1 219 ? 27.40600 30.86500  28.57700 1.000 75.88139  ? 219 MET A N    1 
ATOM   2732 C  CA   . MET A 1 219 ? 28.05200 29.98200  29.53500 1.000 76.22208  ? 219 MET A CA   1 
ATOM   2733 C  C    . MET A 1 219 ? 29.52600 30.34200  29.62600 1.000 66.41342  ? 219 MET A C    1 
ATOM   2734 O  O    . MET A 1 219 ? 30.21000 30.47500  28.60500 1.000 65.95055  ? 219 MET A O    1 
ATOM   2735 C  CB   . MET A 1 219 ? 27.88000 28.51200  29.14500 1.000 75.09488  ? 219 MET A CB   1 
ATOM   2736 C  CG   . MET A 1 219 ? 27.57400 27.58100  30.31900 1.000 96.88487  ? 219 MET A CG   1 
ATOM   2737 S  SD   . MET A 1 219 ? 26.14000 28.07900  31.29900 1.000 86.48369  ? 219 MET A SD   1 
ATOM   2738 C  CE   . MET A 1 219 ? 24.97900 26.78100  30.88000 1.000 79.36474  ? 219 MET A CE   1 
ATOM   2739 H  H    . MET A 1 219 ? 27.70300 30.77700  27.77400 1.000 90.99742  ? 219 MET A H    1 
ATOM   2740 H  HA   . MET A 1 219 ? 27.64200 30.10200  30.40600 1.000 91.40626  ? 219 MET A HA   1 
ATOM   2741 H  HB2  . MET A 1 219 ? 27.14600 28.44300  28.51500 1.000 90.05362  ? 219 MET A HB2  1 
ATOM   2742 H  HB3  . MET A 1 219 ? 28.70200 28.20400  28.73200 1.000 90.05362  ? 219 MET A HB3  1 
ATOM   2743 H  HG2  . MET A 1 219 ? 27.39900 26.69200  29.97300 1.000 116.20160 ? 219 MET A HG2  1 
ATOM   2744 H  HG3  . MET A 1 219 ? 28.34300 27.56200  30.91000 1.000 116.20160 ? 219 MET A HG3  1 
ATOM   2745 H  HE1  . MET A 1 219 ? 24.15000 26.93100  31.36100 1.000 95.17745  ? 219 MET A HE1  1 
ATOM   2746 H  HE2  . MET A 1 219 ? 24.81500 26.80000  29.92400 1.000 95.17745  ? 219 MET A HE2  1 
ATOM   2747 H  HE3  . MET A 1 219 ? 25.35800 25.92500  31.13400 1.000 95.17745  ? 219 MET A HE3  1 
ATOM   2748 N  N    . MET A 1 220 ? 29.99600 30.49600  30.85900 1.000 58.94968  ? 220 MET A N    1 
ATOM   2749 C  CA   . MET A 1 220 ? 31.35500 30.89900  31.21900 1.000 64.25751  ? 220 MET A CA   1 
ATOM   2750 C  C    . MET A 1 220 ? 32.17300 29.68200  31.64200 1.000 68.66258  ? 220 MET A C    1 
ATOM   2751 O  O    . MET A 1 220 ? 32.92100 29.69400  32.61900 1.000 70.87377  ? 220 MET A O    1 
ATOM   2752 C  CB   . MET A 1 220 ? 31.22900 31.96800  32.31000 1.000 62.78711  ? 220 MET A CB   1 
ATOM   2753 C  CG   . MET A 1 220 ? 32.40000 32.36700  33.17000 1.000 61.71665  ? 220 MET A CG   1 
ATOM   2754 S  SD   . MET A 1 220 ? 33.44900 33.60300  32.43500 1.000 79.76439  ? 220 MET A SD   1 
ATOM   2755 C  CE   . MET A 1 220 ? 34.92200 33.14500  33.30500 1.000 59.72390  ? 220 MET A CE   1 
ATOM   2756 H  H    . MET A 1 220 ? 29.51100 30.36400  31.55700 1.000 70.67937  ? 220 MET A H    1 
ATOM   2757 H  HA   . MET A 1 220 ? 31.83500 31.30100  30.47800 1.000 77.04877  ? 220 MET A HA   1 
ATOM   2758 H  HB2  . MET A 1 220 ? 30.93700 32.78200  31.87200 1.000 75.28429  ? 220 MET A HB2  1 
ATOM   2759 H  HB3  . MET A 1 220 ? 30.54600 31.66000  32.92600 1.000 75.28429  ? 220 MET A HB3  1 
ATOM   2760 H  HG2  . MET A 1 220 ? 32.06400 32.72500  34.00600 1.000 73.99974  ? 220 MET A HG2  1 
ATOM   2761 H  HG3  . MET A 1 220 ? 32.94300 31.58200  33.34000 1.000 73.99974  ? 220 MET A HG3  1 
ATOM   2762 H  HE1  . MET A 1 220 ? 35.64100 33.74100  33.04400 1.000 71.60844  ? 220 MET A HE1  1 
ATOM   2763 H  HE2  . MET A 1 220 ? 34.76100 33.21800  34.25900 1.000 71.60844  ? 220 MET A HE2  1 
ATOM   2764 H  HE3  . MET A 1 220 ? 35.15100 32.23000  33.07800 1.000 71.60844  ? 220 MET A HE3  1 
ATOM   2765 N  N    . THR A 1 221 ? 32.04500 28.59600  30.88300 1.000 70.15515  ? 221 THR A N    1 
ATOM   2766 C  CA   . THR A 1 221 ? 32.49000 27.28100  31.32800 1.000 80.79793  ? 221 THR A CA   1 
ATOM   2767 C  C    . THR A 1 221 ? 33.18700 26.53700  30.19600 1.000 90.78711  ? 221 THR A C    1 
ATOM   2768 O  O    . THR A 1 221 ? 33.22600 27.03800  29.06300 1.000 75.73103  ? 221 THR A O    1 
ATOM   2769 C  CB   . THR A 1 221 ? 31.28200 26.48900  31.83700 1.000 89.31211  ? 221 THR A CB   1 
ATOM   2770 O  OG1  . THR A 1 221 ? 30.40600 26.19100  30.74200 1.000 101.57549 ? 221 THR A OG1  1 
ATOM   2771 C  CG2  . THR A 1 221 ? 30.51200 27.29800  32.86600 1.000 85.12647  ? 221 THR A CG2  1 
ATOM   2772 H  H    . THR A 1 221 ? 31.69800 28.59500  30.09600 1.000 84.12594  ? 221 THR A H    1 
ATOM   2773 H  HA   . THR A 1 221 ? 33.13600 27.37600  32.04500 1.000 96.89727  ? 221 THR A HA   1 
ATOM   2774 H  HB   . THR A 1 221 ? 31.58900 25.66600  32.24800 1.000 107.11430 ? 221 THR A HB   1 
ATOM   2775 H  HG1  . THR A 1 221 ? 30.81000 26.30100  30.01300 1.000 121.83035 ? 221 THR A HG1  1 
ATOM   2776 H  HG21 . THR A 1 221 ? 29.86300 26.73400  33.31400 1.000 102.09152 ? 221 THR A HG21 1 
ATOM   2777 H  HG22 . THR A 1 221 ? 31.12300 27.66100  33.52700 1.000 102.09152 ? 221 THR A HG22 1 
ATOM   2778 H  HG23 . THR A 1 221 ? 30.04700 28.03000  32.43200 1.000 102.09152 ? 221 THR A HG23 1 
ATOM   2779 N  N    . PRO A 1 222 ? 33.75700 25.35200  30.44600 1.000 103.41730 ? 222 PRO A N    1 
ATOM   2780 C  CA   . PRO A 1 222 ? 34.26900 24.53900  29.33400 1.000 97.57786  ? 222 PRO A CA   1 
ATOM   2781 C  C    . PRO A 1 222 ? 33.17100 23.99100  28.44100 1.000 90.68316  ? 222 PRO A C    1 
ATOM   2782 O  O    . PRO A 1 222 ? 33.47300 23.36200  27.42200 1.000 86.54846  ? 222 PRO A O    1 
ATOM   2783 C  CB   . PRO A 1 222 ? 35.02100 23.39100  30.03000 1.000 92.96135  ? 222 PRO A CB   1 
ATOM   2784 C  CG   . PRO A 1 222 ? 34.94700 23.64600  31.49800 1.000 98.11945  ? 222 PRO A CG   1 
ATOM   2785 C  CD   . PRO A 1 222 ? 33.91700 24.68900  31.75400 1.000 97.52253  ? 222 PRO A CD   1 
ATOM   2786 H  HA   . PRO A 1 222 ? 34.90300 25.05300  28.81100 1.000 117.03319 ? 222 PRO A HA   1 
ATOM   2787 H  HB2  . PRO A 1 222 ? 34.59500 22.54700  29.81000 1.000 111.49338 ? 222 PRO A HB2  1 
ATOM   2788 H  HB3  . PRO A 1 222 ? 35.94400 23.38400  29.73300 1.000 111.49338 ? 222 PRO A HB3  1 
ATOM   2789 H  HG2  . PRO A 1 222 ? 34.70400 22.82200  31.94800 1.000 117.68311 ? 222 PRO A HG2  1 
ATOM   2790 H  HG3  . PRO A 1 222 ? 35.81400 23.95100  31.80800 1.000 117.68311 ? 222 PRO A HG3  1 
ATOM   2791 H  HD2  . PRO A 1 222 ? 33.08200 24.28600  32.03900 1.000 116.96679 ? 222 PRO A HD2  1 
ATOM   2792 H  HD3  . PRO A 1 222 ? 34.22600 25.32000  32.42300 1.000 116.96679 ? 222 PRO A HD3  1 
ATOM   2793 N  N    . TYR A 1 223 ? 31.91100 24.21900  28.79600 1.000 88.80900  ? 223 TYR A N    1 
ATOM   2794 C  CA   . TYR A 1 223 ? 30.79600 23.57800  28.12200 1.000 85.72309  ? 223 TYR A CA   1 
ATOM   2795 C  C    . TYR A 1 223 ? 30.61400 24.13100  26.71300 1.000 78.96040  ? 223 TYR A C    1 
ATOM   2796 O  O    . TYR A 1 223 ? 30.90600 25.29800  26.43500 1.000 80.31817  ? 223 TYR A O    1 
ATOM   2797 C  CB   . TYR A 1 223 ? 29.51400 23.78000  28.93100 1.000 94.82765  ? 223 TYR A CB   1 
ATOM   2798 C  CG   . TYR A 1 223 ? 29.63300 23.46300  30.41400 1.000 120.80485 ? 223 TYR A CG   1 
ATOM   2799 C  CD1  . TYR A 1 223 ? 30.67300 22.68100  30.90600 1.000 116.62049 ? 223 TYR A CD1  1 
ATOM   2800 C  CD2  . TYR A 1 223 ? 28.70400 23.95800  31.32400 1.000 124.43444 ? 223 TYR A CD2  1 
ATOM   2801 C  CE1  . TYR A 1 223 ? 30.78000 22.39800  32.25500 1.000 119.67288 ? 223 TYR A CE1  1 
ATOM   2802 C  CE2  . TYR A 1 223 ? 28.80300 23.67900  32.67300 1.000 115.64273 ? 223 TYR A CE2  1 
ATOM   2803 C  CZ   . TYR A 1 223 ? 29.84200 22.89900  33.13300 1.000 123.82835 ? 223 TYR A CZ   1 
ATOM   2804 O  OH   . TYR A 1 223 ? 29.94200 22.61900  34.47600 1.000 129.46726 ? 223 TYR A OH   1 
ATOM   2805 H  H    . TYR A 1 223 ? 31.67400 24.74900  29.43100 1.000 106.51056 ? 223 TYR A H    1 
ATOM   2806 H  HA   . TYR A 1 223 ? 30.96900 22.62600  28.04600 1.000 102.80747 ? 223 TYR A HA   1 
ATOM   2807 H  HB2  . TYR A 1 223 ? 29.24600 24.70900  28.85400 1.000 113.73294 ? 223 TYR A HB2  1 
ATOM   2808 H  HB3  . TYR A 1 223 ? 28.82600 23.20400  28.56500 1.000 113.73294 ? 223 TYR A HB3  1 
ATOM   2809 H  HD1  . TYR A 1 223 ? 31.30800 22.34200  30.31700 1.000 139.88434 ? 223 TYR A HD1  1 
ATOM   2810 H  HD2  . TYR A 1 223 ? 28.00200 24.48600  31.01700 1.000 149.26109 ? 223 TYR A HD2  1 
ATOM   2811 H  HE1  . TYR A 1 223 ? 31.48000 21.87300  32.56800 1.000 143.54722 ? 223 TYR A HE1  1 
ATOM   2812 H  HE2  . TYR A 1 223 ? 28.17300 24.01600  33.26800 1.000 138.71104 ? 223 TYR A HE2  1 
ATOM   2813 H  HH   . TYR A 1 223 ? 29.31700 22.99300  34.89500 1.000 155.30047 ? 223 TYR A HH   1 
ATOM   2814 N  N    . VAL A 1 224 ? 30.13800 23.27100  25.81500 1.000 77.35141  ? 224 VAL A N    1 
ATOM   2815 C  CA   . VAL A 1 224 ? 29.76000 23.67100  24.46300 1.000 75.56621  ? 224 VAL A CA   1 
ATOM   2816 C  C    . VAL A 1 224 ? 28.48900 22.92700  24.07800 1.000 62.84309  ? 224 VAL A C    1 
ATOM   2817 O  O    . VAL A 1 224 ? 28.32100 21.74800  24.40900 1.000 62.27606  ? 224 VAL A O    1 
ATOM   2818 C  CB   . VAL A 1 224 ? 30.87700 23.40000  23.43300 1.000 77.47156  ? 224 VAL A CB   1 
ATOM   2819 C  CG1  . VAL A 1 224 ? 31.21100 21.91200  23.36900 1.000 77.88146  ? 224 VAL A CG1  1 
ATOM   2820 C  CG2  . VAL A 1 224 ? 30.46500 23.92400  22.05800 1.000 64.95434  ? 224 VAL A CG2  1 
ATOM   2821 H  H    . VAL A 1 224 ? 30.02300 22.43300  25.96900 1.000 92.76145  ? 224 VAL A H    1 
ATOM   2822 H  HA   . VAL A 1 224 ? 29.57900 24.62400  24.46300 1.000 90.61922  ? 224 VAL A HA   1 
ATOM   2823 H  HB   . VAL A 1 224 ? 31.67900 23.86900  23.71200 1.000 92.90563  ? 224 VAL A HB   1 
ATOM   2824 H  HG11 . VAL A 1 224 ? 31.97700 21.78500  22.78800 1.000 93.39751  ? 224 VAL A HG11 1 
ATOM   2825 H  HG12 . VAL A 1 224 ? 31.41700 21.59600  24.26200 1.000 93.39751  ? 224 VAL A HG12 1 
ATOM   2826 H  HG13 . VAL A 1 224 ? 30.44500 21.43200  23.01600 1.000 93.39751  ? 224 VAL A HG13 1 
ATOM   2827 H  HG21 . VAL A 1 224 ? 31.25300 23.98600  21.49500 1.000 77.88497  ? 224 VAL A HG21 1 
ATOM   2828 H  HG22 . VAL A 1 224 ? 29.82500 23.31000  21.66500 1.000 77.88497  ? 224 VAL A HG22 1 
ATOM   2829 H  HG23 . VAL A 1 224 ? 30.06300 24.80000  22.16200 1.000 77.88497  ? 224 VAL A HG23 1 
ATOM   2830 N  N    . VAL A 1 225 ? 27.60200 23.61500  23.36700 1.000 52.80999  ? 225 VAL A N    1 
ATOM   2831 C  CA   . VAL A 1 225 ? 26.29100 23.08400  23.01100 1.000 56.67702  ? 225 VAL A CA   1 
ATOM   2832 C  C    . VAL A 1 225 ? 26.38600 22.36000  21.67600 1.000 37.79662  ? 225 VAL A C    1 
ATOM   2833 O  O    . VAL A 1 225 ? 27.03600 22.83400  20.73800 1.000 38.50656  ? 225 VAL A O    1 
ATOM   2834 C  CB   . VAL A 1 225 ? 25.24800 24.21800  22.95700 1.000 50.84159  ? 225 VAL A CB   1 
ATOM   2835 C  CG1  . VAL A 1 225 ? 23.90900 23.70400  22.44100 1.000 48.76401  ? 225 VAL A CG1  1 
ATOM   2836 C  CG2  . VAL A 1 225 ? 25.08600 24.85300  24.33200 1.000 60.62216  ? 225 VAL A CG2  1 
ATOM   2837 H  H    . VAL A 1 225 ? 27.74000 24.41100  23.07100 1.000 63.31175  ? 225 VAL A H    1 
ATOM   2838 H  HA   . VAL A 1 225 ? 26.01600 22.44100  23.68300 1.000 67.95219  ? 225 VAL A HA   1 
ATOM   2839 H  HB   . VAL A 1 225 ? 25.56000 24.89800  22.33900 1.000 60.94967  ? 225 VAL A HB   1 
ATOM   2840 H  HG11 . VAL A 1 225 ? 23.27200 24.43600  22.43200 1.000 58.45658  ? 225 VAL A HG11 1 
ATOM   2841 H  HG12 . VAL A 1 225 ? 24.02800 23.35900  21.54300 1.000 58.45658  ? 225 VAL A HG12 1 
ATOM   2842 H  HG13 . VAL A 1 225 ? 23.59400 22.99900  23.02800 1.000 58.45658  ? 225 VAL A HG13 1 
ATOM   2843 H  HG21 . VAL A 1 225 ? 24.42700 25.56200  24.27700 1.000 72.68635  ? 225 VAL A HG21 1 
ATOM   2844 H  HG22 . VAL A 1 225 ? 24.79100 24.17500  24.96000 1.000 72.68635  ? 225 VAL A HG22 1 
ATOM   2845 H  HG23 . VAL A 1 225 ? 25.94000 25.21600  24.61500 1.000 72.68635  ? 225 VAL A HG23 1 
ATOM   2846 N  N    . THR A 1 226 ? 25.73400 21.20400  21.59300 1.000 39.85353  ? 226 THR A N    1 
ATOM   2847 C  CA   . THR A 1 226 ? 25.63900 20.44600  20.35000 1.000 34.88172  ? 226 THR A CA   1 
ATOM   2848 C  C    . THR A 1 226 ? 24.45300 20.97300  19.55000 1.000 33.70518  ? 226 THR A C    1 
ATOM   2849 O  O    . THR A 1 226 ? 23.31400 20.94700  20.03000 1.000 34.28535  ? 226 THR A O    1 
ATOM   2850 C  CB   . THR A 1 226 ? 25.48400 18.95400  20.63700 1.000 28.69196  ? 226 THR A CB   1 
ATOM   2851 O  OG1  . THR A 1 226 ? 26.65600 18.47300  21.30600 1.000 34.29553  ? 226 THR A OG1  1 
ATOM   2852 C  CG2  . THR A 1 226 ? 25.28200 18.16400  19.34400 1.000 34.43502  ? 226 THR A CG2  1 
ATOM   2853 H  H    . THR A 1 226 ? 25.33100 20.83100  22.25500 1.000 47.76399  ? 226 THR A H    1 
ATOM   2854 H  HA   . THR A 1 226 ? 26.44700 20.56500  19.82700 1.000 41.79782  ? 226 THR A HA   1 
ATOM   2855 H  HB   . THR A 1 226 ? 24.70500 18.81600  21.19800 1.000 34.37011  ? 226 THR A HB   1 
ATOM   2856 H  HG1  . THR A 1 226 ? 26.60100 17.64200  21.42000 1.000 41.09440  ? 226 THR A HG1  1 
ATOM   2857 H  HG21 . THR A 1 226 ? 25.34500 17.21300  19.52300 1.000 41.26179  ? 226 THR A HG21 1 
ATOM   2858 H  HG22 . THR A 1 226 ? 24.40800 18.35700  18.97100 1.000 41.26179  ? 226 THR A HG22 1 
ATOM   2859 H  HG23 . THR A 1 226 ? 25.96200 18.40800  18.69700 1.000 41.26179  ? 226 THR A HG23 1 
ATOM   2860 N  N    . ARG A 1 227 ? 24.72300 21.44300  18.33200 1.000 32.46902  ? 227 ARG A N    1 
ATOM   2861 C  CA   . ARG A 1 227 ? 23.73100 22.12200  17.51400 1.000 28.42723  ? 227 ARG A CA   1 
ATOM   2862 C  C    . ARG A 1 227 ? 23.38200 21.37900  16.23400 1.000 25.79029  ? 227 ARG A C    1 
ATOM   2863 O  O    . ARG A 1 227 ? 22.52300 21.85000  15.48000 1.000 27.07117  ? 227 ARG A O    1 
ATOM   2864 C  CB   . ARG A 1 227 ? 24.23100 23.52300  17.14000 1.000 38.75718  ? 227 ARG A CB   1 
ATOM   2865 C  CG   . ARG A 1 227 ? 24.63600 24.37600  18.32500 1.000 45.35686  ? 227 ARG A CG   1 
ATOM   2866 C  CD   . ARG A 1 227 ? 25.67700 25.40300  17.92300 1.000 60.16453  ? 227 ARG A CD   1 
ATOM   2867 N  NE   . ARG A 1 227 ? 25.18000 26.75700  18.12700 1.000 68.87829  ? 227 ARG A NE   1 
ATOM   2868 C  CZ   . ARG A 1 227 ? 25.66300 27.83400  17.52500 1.000 84.90174  ? 227 ARG A CZ   1 
ATOM   2869 N  NH1  . ARG A 1 227 ? 26.66000 27.75500  16.65800 1.000 70.45587  ? 227 ARG A NH1  1 
ATOM   2870 N  NH2  . ARG A 1 227 ? 25.13000 29.02100  17.79600 1.000 81.86672  ? 227 ARG A NH2  1 
ATOM   2871 H  H    . ARG A 1 227 ? 25.49200 21.37800  17.95300 1.000 38.90259  ? 227 ARG A H    1 
ATOM   2872 H  HA   . ARG A 1 227 ? 22.91900 22.20800  18.03800 1.000 34.05244  ? 227 ARG A HA   1 
ATOM   2873 H  HB2  . ARG A 1 227 ? 25.00700 23.43100  16.56500 1.000 46.44837  ? 227 ARG A HB2  1 
ATOM   2874 H  HB3  . ARG A 1 227 ? 23.52300 23.99000  16.67000 1.000 46.44837  ? 227 ARG A HB3  1 
ATOM   2875 H  HG2  . ARG A 1 227 ? 23.85900 24.84400  18.66800 1.000 54.36799  ? 227 ARG A HG2  1 
ATOM   2876 H  HG3  . ARG A 1 227 ? 25.01400 23.81000  19.01700 1.000 54.36799  ? 227 ARG A HG3  1 
ATOM   2877 H  HD2  . ARG A 1 227 ? 26.47400 25.28400  18.46300 1.000 72.13720  ? 227 ARG A HD2  1 
ATOM   2878 H  HD3  . ARG A 1 227 ? 25.89300 25.29400  16.98400 1.000 72.13720  ? 227 ARG A HD3  1 
ATOM   2879 H  HE   . ARG A 1 227 ? 24.52800 26.86500  18.67600 1.000 82.59371  ? 227 ARG A HE   1 
ATOM   2880 H  HH11 . ARG A 1 227 ? 27.00900 26.99100  16.47300 1.000 84.48681  ? 227 ARG A HH11 1 
ATOM   2881 H  HH12 . ARG A 1 227 ? 26.95800 28.46700  16.27900 1.000 84.48681  ? 227 ARG A HH12 1 
ATOM   2882 H  HH21 . ARG A 1 227 ? 24.47900 29.08300  18.35600 1.000 98.17983  ? 227 ARG A HH21 1 
ATOM   2883 H  HH22 . ARG A 1 227 ? 25.43400 29.72800  17.41200 1.000 98.17983  ? 227 ARG A HH22 1 
ATOM   2884 N  N    . TYR A 1 228 ? 24.01100 20.23200  15.97200 1.000 25.19969  ? 228 TYR A N    1 
ATOM   2885 C  CA   . TYR A 1 228 ? 23.92900 19.60900  14.65600 1.000 29.62060  ? 228 TYR A CA   1 
ATOM   2886 C  C    . TYR A 1 228 ? 22.54000 19.07800  14.32300 1.000 34.90063  ? 228 TYR A C    1 
ATOM   2887 O  O    . TYR A 1 228 ? 22.26300 18.81500  13.14900 1.000 24.18373  ? 228 TYR A O    1 
ATOM   2888 C  CB   . TYR A 1 228 ? 24.94500 18.46700  14.56000 1.000 33.60274  ? 228 TYR A CB   1 
ATOM   2889 C  CG   . TYR A 1 228 ? 26.31700 18.82700  15.07900 1.000 28.11660  ? 228 TYR A CG   1 
ATOM   2890 C  CD1  . TYR A 1 228 ? 26.95200 19.98900  14.66600 1.000 35.55481  ? 228 TYR A CD1  1 
ATOM   2891 C  CD2  . TYR A 1 228 ? 26.97500 18.00500  15.98400 1.000 40.89007  ? 228 TYR A CD2  1 
ATOM   2892 C  CE1  . TYR A 1 228 ? 28.20600 20.32400  15.13800 1.000 38.13821  ? 228 TYR A CE1  1 
ATOM   2893 C  CE2  . TYR A 1 228 ? 28.23000 18.33100  16.46200 1.000 37.05804  ? 228 TYR A CE2  1 
ATOM   2894 C  CZ   . TYR A 1 228 ? 28.84000 19.49200  16.03600 1.000 45.79696  ? 228 TYR A CZ   1 
ATOM   2895 O  OH   . TYR A 1 228 ? 30.09000 19.82500  16.50900 1.000 44.38123  ? 228 TYR A OH   1 
ATOM   2896 H  H    . TYR A 1 228 ? 24.49000 19.79800  16.53900 1.000 30.17939  ? 228 TYR A H    1 
ATOM   2897 H  HA   . TYR A 1 228 ? 24.14800 20.28200  13.99200 1.000 35.48448  ? 228 TYR A HA   1 
ATOM   2898 H  HB2  . TYR A 1 228 ? 24.61900 17.71600  15.08000 1.000 40.26305  ? 228 TYR A HB2  1 
ATOM   2899 H  HB3  . TYR A 1 228 ? 25.03900 18.21000  13.62900 1.000 40.26305  ? 228 TYR A HB3  1 
ATOM   2900 H  HD1  . TYR A 1 228 ? 26.52600 20.55200  14.06100 1.000 42.60553  ? 228 TYR A HD1  1 
ATOM   2901 H  HD2  . TYR A 1 228 ? 26.56500 17.22200  16.27300 1.000 49.00785  ? 228 TYR A HD2  1 
ATOM   2902 H  HE1  . TYR A 1 228 ? 28.62000 21.10600  14.85100 1.000 45.70561  ? 228 TYR A HE1  1 
ATOM   2903 H  HE2  . TYR A 1 228 ? 28.66000 17.77100  17.06700 1.000 44.40942  ? 228 TYR A HE2  1 
ATOM   2904 H  HH   . TYR A 1 228 ? 30.29600 19.32600  17.15200 1.000 53.19724  ? 228 TYR A HH   1 
ATOM   2905 N  N    . TYR A 1 229 ? 21.66400 18.90700  15.31300 1.000 22.74383  ? 229 TYR A N    1 
ATOM   2906 C  CA   . TYR A 1 229 ? 20.35200 18.31400  15.08000 1.000 22.13202  ? 229 TYR A CA   1 
ATOM   2907 C  C    . TYR A 1 229 ? 19.23200 19.34800  15.06200 1.000 26.98003  ? 229 TYR A C    1 
ATOM   2908 O  O    . TYR A 1 229 ? 18.05600 18.97500  15.02000 1.000 25.50130  ? 229 TYR A O    1 
ATOM   2909 C  CB   . TYR A 1 229 ? 20.07600 17.23800  16.13300 1.000 23.63666  ? 229 TYR A CB   1 
ATOM   2910 C  CG   . TYR A 1 229 ? 21.19800 16.22400  16.23800 1.000 25.54522  ? 229 TYR A CG   1 
ATOM   2911 C  CD1  . TYR A 1 229 ? 22.30000 16.46300  17.04800 1.000 22.49155  ? 229 TYR A CD1  1 
ATOM   2912 C  CD2  . TYR A 1 229 ? 21.16900 15.04500  15.50400 1.000 25.34557  ? 229 TYR A CD2  1 
ATOM   2913 C  CE1  . TYR A 1 229 ? 23.33200 15.55100  17.14000 1.000 20.70404  ? 229 TYR A CE1  1 
ATOM   2914 C  CE2  . TYR A 1 229 ? 22.19900 14.12300  15.59000 1.000 23.54351  ? 229 TYR A CE2  1 
ATOM   2915 C  CZ   . TYR A 1 229 ? 23.27900 14.38500  16.40800 1.000 25.10055  ? 229 TYR A CZ   1 
ATOM   2916 O  OH   . TYR A 1 229 ? 24.30800 13.48000  16.50000 1.000 26.19111  ? 229 TYR A OH   1 
ATOM   2917 H  H    . TYR A 1 229 ? 21.80900 19.12900  16.13200 1.000 27.23236  ? 229 TYR A H    1 
ATOM   2918 H  HA   . TYR A 1 229 ? 20.35500 17.88300  14.21100 1.000 26.49818  ? 229 TYR A HA   1 
ATOM   2919 H  HB2  . TYR A 1 229 ? 19.97100 17.66200  16.99900 1.000 28.30375  ? 229 TYR A HB2  1 
ATOM   2920 H  HB3  . TYR A 1 229 ? 19.26400 16.76400  15.89500 1.000 28.30375  ? 229 TYR A HB3  1 
ATOM   2921 H  HD1  . TYR A 1 229 ? 22.34300 17.25300  17.53800 1.000 26.92962  ? 229 TYR A HD1  1 
ATOM   2922 H  HD2  . TYR A 1 229 ? 20.44700 14.87200  14.94500 1.000 30.35445  ? 229 TYR A HD2  1 
ATOM   2923 H  HE1  . TYR A 1 229 ? 24.06000 15.72300  17.69300 1.000 24.78461  ? 229 TYR A HE1  1 
ATOM   2924 H  HE2  . TYR A 1 229 ? 22.16300 13.33300  15.10100 1.000 28.19197  ? 229 TYR A HE2  1 
ATOM   2925 H  HH   . TYR A 1 229 ? 24.15800 12.82100  16.00100 1.000 31.36909  ? 229 TYR A HH   1 
ATOM   2926 N  N    . ARG A 1 230 ? 19.56700 20.63500  15.05900 1.000 26.87152  ? 230 ARG A N    1 
ATOM   2927 C  CA   . ARG A 1 230 ? 18.56400 21.68800  15.08300 1.000 25.24173  ? 230 ARG A CA   1 
ATOM   2928 C  C    . ARG A 1 230 ? 18.07900 21.99900  13.67500 1.000 21.55650  ? 230 ARG A C    1 
ATOM   2929 O  O    . ARG A 1 230 ? 18.84800 21.95500  12.71000 1.000 25.02788  ? 230 ARG A O    1 
ATOM   2930 C  CB   . ARG A 1 230 ? 19.13000 22.94800  15.74300 1.000 26.29513  ? 230 ARG A CB   1 
ATOM   2931 C  CG   . ARG A 1 230 ? 19.59000 22.71700  17.17800 1.000 27.61003  ? 230 ARG A CG   1 
ATOM   2932 C  CD   . ARG A 1 230 ? 20.18000 23.97500  17.78800 1.000 29.77844  ? 230 ARG A CD   1 
ATOM   2933 N  NE   . ARG A 1 230 ? 20.35200 23.84800  19.23000 1.000 29.98656  ? 230 ARG A NE   1 
ATOM   2934 C  CZ   . ARG A 1 230 ? 20.93700 24.75800  19.99800 1.000 33.96854  ? 230 ARG A CZ   1 
ATOM   2935 N  NH1  . ARG A 1 230 ? 21.41700 25.88300  19.49400 1.000 34.44151  ? 230 ARG A NH1  1 
ATOM   2936 N  NH2  . ARG A 1 230 ? 21.03700 24.53500  21.30500 1.000 27.79286  ? 230 ARG A NH2  1 
ATOM   2937 H  H    . ARG A 1 230 ? 20.37700 20.92400  15.04400 1.000 32.18559  ? 230 ARG A H    1 
ATOM   2938 H  HA   . ARG A 1 230 ? 17.79800 21.39300  15.60000 1.000 30.22984  ? 230 ARG A HA   1 
ATOM   2939 H  HB2  . ARG A 1 230 ? 19.89300 23.25600  15.23000 1.000 31.49391  ? 230 ARG A HB2  1 
ATOM   2940 H  HB3  . ARG A 1 230 ? 18.44200 23.63200  15.75700 1.000 31.49391  ? 230 ARG A HB3  1 
ATOM   2941 H  HG2  . ARG A 1 230 ? 18.83200 22.44400  17.71800 1.000 33.07180  ? 230 ARG A HG2  1 
ATOM   2942 H  HG3  . ARG A 1 230 ? 20.27100 22.02600  17.18900 1.000 33.07180  ? 230 ARG A HG3  1 
ATOM   2943 H  HD2  . ARG A 1 230 ? 21.05000 24.14500  17.39300 1.000 35.67389  ? 230 ARG A HD2  1 
ATOM   2944 H  HD3  . ARG A 1 230 ? 19.58600 24.72200  17.61700 1.000 35.67389  ? 230 ARG A HD3  1 
ATOM   2945 H  HE   . ARG A 1 230 ? 20.05300 23.13600  19.60800 1.000 35.92363  ? 230 ARG A HE   1 
ATOM   2946 H  HH11 . ARG A 1 230 ? 21.35300 26.03800  18.65000 1.000 41.26957  ? 230 ARG A HH11 1 
ATOM   2947 H  HH12 . ARG A 1 230 ? 21.79300 26.45900  20.01000 1.000 41.26957  ? 230 ARG A HH12 1 
ATOM   2948 H  HH21 . ARG A 1 230 ? 20.72500 23.80900  21.64300 1.000 33.29119  ? 230 ARG A HH21 1 
ATOM   2949 H  HH22 . ARG A 1 230 ? 21.41500 25.11800  21.81300 1.000 33.29119  ? 230 ARG A HH22 1 
ATOM   2950 N  N    . ALA A 1 231 ? 16.79100 22.31700  13.56900 1.000 22.00540  ? 231 ALA A N    1 
ATOM   2951 C  CA   . ALA A 1 231 ? 16.15700 22.51900  12.28200 1.000 20.06022  ? 231 ALA A CA   1 
ATOM   2952 C  C    . ALA A 1 231 ? 16.59800 23.83600  11.65300 1.000 29.07839  ? 231 ALA A C    1 
ATOM   2953 O  O    . ALA A 1 231 ? 17.08500 24.73400  12.34300 1.000 24.99358  ? 231 ALA A O    1 
ATOM   2954 C  CB   . ALA A 1 231 ? 14.64000 22.51700  12.43900 1.000 23.82936  ? 231 ALA A CB   1 
ATOM   2955 H  H    . ALA A 1 231 ? 16.26100 22.42200  14.23700 1.000 26.34624  ? 231 ALA A H    1 
ATOM   2956 H  HA   . ALA A 1 231 ? 16.41600 21.79800  11.68700 1.000 24.01203  ? 231 ALA A HA   1 
ATOM   2957 H  HB1  . ALA A 1 231 ? 14.23100 22.58000  11.56100 1.000 28.53499  ? 231 ALA A HB1  1 
ATOM   2958 H  HB2  . ALA A 1 231 ? 14.36800 21.69300  12.87200 1.000 28.53499  ? 231 ALA A HB2  1 
ATOM   2959 H  HB3  . ALA A 1 231 ? 14.37700 23.27800  12.98100 1.000 28.53499  ? 231 ALA A HB3  1 
ATOM   2960 N  N    . PRO A 1 232 ? 16.42100 23.97800  10.33300 1.000 29.00280  ? 232 PRO A N    1 
ATOM   2961 C  CA   . PRO A 1 232 ? 16.69000 25.28100  9.70400  1.000 27.23714  ? 232 PRO A CA   1 
ATOM   2962 C  C    . PRO A 1 232 ? 15.95000 26.42500  10.37300 1.000 24.81964  ? 232 PRO A C    1 
ATOM   2963 O  O    . PRO A 1 232 ? 16.48800 27.53500  10.45900 1.000 30.94127  ? 232 PRO A O    1 
ATOM   2964 C  CB   . PRO A 1 232 ? 16.22900 25.07200  8.25400  1.000 21.67018  ? 232 PRO A CB   1 
ATOM   2965 C  CG   . PRO A 1 232 ? 16.32000 23.59700  8.03000  1.000 23.51561  ? 232 PRO A CG   1 
ATOM   2966 C  CD   . PRO A 1 232 ? 15.99000 22.96500  9.35300  1.000 32.49907  ? 232 PRO A CD   1 
ATOM   2967 H  HA   . PRO A 1 232 ? 17.64300 25.46100  9.71000  1.000 32.62433  ? 232 PRO A HA   1 
ATOM   2968 H  HB2  . PRO A 1 232 ? 15.31700 25.38300  8.15000  1.000 25.94398  ? 232 PRO A HB2  1 
ATOM   2969 H  HB3  . PRO A 1 232 ? 16.81500 25.55200  7.64900  1.000 25.94398  ? 232 PRO A HB3  1 
ATOM   2970 H  HG2  . PRO A 1 232 ? 15.68200 23.32900  7.35100  1.000 28.15849  ? 232 PRO A HG2  1 
ATOM   2971 H  HG3  . PRO A 1 232 ? 17.21900 23.36300  7.75100  1.000 28.15849  ? 232 PRO A HG3  1 
ATOM   2972 H  HD2  . PRO A 1 232 ? 15.03700 22.79800  9.42700  1.000 38.93864  ? 232 PRO A HD2  1 
ATOM   2973 H  HD3  . PRO A 1 232 ? 16.48200 22.13800  9.47300  1.000 38.93864  ? 232 PRO A HD3  1 
ATOM   2974 N  N    . GLU A 1 233 ? 14.72500 26.18600  10.85200 1.000 32.29150  ? 233 GLU A N    1 
ATOM   2975 C  CA   . GLU A 1 233 ? 14.00100 27.22800  11.57300 1.000 31.30632  ? 233 GLU A CA   1 
ATOM   2976 C  C    . GLU A 1 233 ? 14.83400 27.76600  12.72700 1.000 30.78791  ? 233 GLU A C    1 
ATOM   2977 O  O    . GLU A 1 233 ? 14.83400 28.97300  13.00200 1.000 30.39548  ? 233 GLU A O    1 
ATOM   2978 C  CB   . GLU A 1 233 ? 12.67100 26.69500  12.11600 1.000 34.60544  ? 233 GLU A CB   1 
ATOM   2979 C  CG   . GLU A 1 233 ? 11.70300 26.14000  11.08800 1.000 40.64719  ? 233 GLU A CG   1 
ATOM   2980 C  CD   . GLU A 1 233 ? 11.92700 24.66100  10.82200 1.000 31.54464  ? 233 GLU A CD   1 
ATOM   2981 O  OE1  . GLU A 1 233 ? 13.03000 24.29700  10.35900 1.000 27.34582  ? 233 GLU A OE1  1 
ATOM   2982 O  OE2  . GLU A 1 233 ? 11.01000 23.86100  11.10200 1.000 25.99471  ? 233 GLU A OE2  1 
ATOM   2983 H  H    . GLU A 1 233 ? 14.30100 25.44100  10.77300 1.000 38.68957  ? 233 GLU A H    1 
ATOM   2984 H  HA   . GLU A 1 233 ? 13.80600 27.94600  10.95000 1.000 37.50735  ? 233 GLU A HA   1 
ATOM   2985 H  HB2  . GLU A 1 233 ? 12.86500 25.98000  12.74200 1.000 41.46629  ? 233 GLU A HB2  1 
ATOM   2986 H  HB3  . GLU A 1 233 ? 12.21900 27.42100  12.57300 1.000 41.46629  ? 233 GLU A HB3  1 
ATOM   2987 H  HG2  . GLU A 1 233 ? 10.79600 26.25400  11.41200 1.000 48.71639  ? 233 GLU A HG2  1 
ATOM   2988 H  HG3  . GLU A 1 233 ? 11.81900 26.61800  10.25200 1.000 48.71639  ? 233 GLU A HG3  1 
ATOM   2989 N  N    . VAL A 1 234 ? 15.54100 26.87800  13.42300 1.000 27.93040  ? 234 VAL A N    1 
ATOM   2990 C  CA   . VAL A 1 234 ? 16.33700 27.28700  14.57400 1.000 27.70717  ? 234 VAL A CA   1 
ATOM   2991 C  C    . VAL A 1 234 ? 17.65600 27.89300  14.12000 1.000 30.59488  ? 234 VAL A C    1 
ATOM   2992 O  O    . VAL A 1 234 ? 18.10000 28.91600  14.65400 1.000 29.32451  ? 234 VAL A O    1 
ATOM   2993 C  CB   . VAL A 1 234 ? 16.55800 26.08100  15.50900 1.000 27.85841  ? 234 VAL A CB   1 
ATOM   2994 C  CG1  . VAL A 1 234 ? 17.43100 26.47200  16.69400 1.000 27.54361  ? 234 VAL A CG1  1 
ATOM   2995 C  CG2  . VAL A 1 234 ? 15.22200 25.52100  15.97400 1.000 29.21216  ? 234 VAL A CG2  1 
ATOM   2996 H  H    . VAL A 1 234 ? 15.57500 26.03600  13.25100 1.000 33.45624  ? 234 VAL A H    1 
ATOM   2997 H  HA   . VAL A 1 234 ? 15.85200 27.96700  15.06700 1.000 33.18836  ? 234 VAL A HA   1 
ATOM   2998 H  HB   . VAL A 1 234 ? 17.02100 25.38300  15.02000 1.000 33.36986  ? 234 VAL A HB   1 
ATOM   2999 H  HG11 . VAL A 1 234 ? 17.42200 25.75200  17.34400 1.000 32.99209  ? 234 VAL A HG11 1 
ATOM   3000 H  HG12 . VAL A 1 234 ? 18.33700 26.62500  16.38200 1.000 32.99209  ? 234 VAL A HG12 1 
ATOM   3001 H  HG13 . VAL A 1 234 ? 17.07700 27.28200  17.09400 1.000 32.99209  ? 234 VAL A HG13 1 
ATOM   3002 H  HG21 . VAL A 1 234 ? 15.38400 24.76300  16.55700 1.000 34.99435  ? 234 VAL A HG21 1 
ATOM   3003 H  HG22 . VAL A 1 234 ? 14.74100 26.21200  16.45600 1.000 34.99435  ? 234 VAL A HG22 1 
ATOM   3004 H  HG23 . VAL A 1 234 ? 14.71100 25.24000  15.19900 1.000 34.99435  ? 234 VAL A HG23 1 
ATOM   3005 N  N    . ILE A 1 235 ? 18.30200 27.27500  13.12900 1.000 26.68588  ? 235 ILE A N    1 
ATOM   3006 C  CA   . ILE A 1 235 ? 19.55600 27.81100  12.60800 1.000 28.87445  ? 235 ILE A CA   1 
ATOM   3007 C  C    . ILE A 1 235 ? 19.35800 29.24200  12.12700 1.000 29.25404  ? 235 ILE A C    1 
ATOM   3008 O  O    . ILE A 1 235 ? 20.20200 30.11500  12.36500 1.000 33.78542  ? 235 ILE A O    1 
ATOM   3009 C  CB   . ILE A 1 235 ? 20.09300 26.90600  11.48300 1.000 30.64322  ? 235 ILE A CB   1 
ATOM   3010 C  CG1  . ILE A 1 235 ? 20.30800 25.48300  12.00200 1.000 36.55699  ? 235 ILE A CG1  1 
ATOM   3011 C  CG2  . ILE A 1 235 ? 21.40300 27.45100  10.91800 1.000 29.69391  ? 235 ILE A CG2  1 
ATOM   3012 C  CD1  . ILE A 1 235 ? 21.06100 24.58300  11.03600 1.000 44.25866  ? 235 ILE A CD1  1 
ATOM   3013 H  H    . ILE A 1 235 ? 18.03800 26.55200  12.74500 1.000 31.96282  ? 235 ILE A H    1 
ATOM   3014 H  HA   . ILE A 1 235 ? 20.21000 27.82300  13.32400 1.000 34.58910  ? 235 ILE A HA   1 
ATOM   3015 H  HB   . ILE A 1 235 ? 19.43000 26.89400  10.77500 1.000 36.71163  ? 235 ILE A HB   1 
ATOM   3016 H  HG12 . ILE A 1 235 ? 20.81900 25.52500  12.82600 1.000 43.80815  ? 235 ILE A HG12 1 
ATOM   3017 H  HG13 . ILE A 1 235 ? 19.44300 25.07800  12.17000 1.000 43.80815  ? 235 ILE A HG13 1 
ATOM   3018 H  HG21 . ILE A 1 235 ? 21.57900 27.02600  10.06400 1.000 35.57246  ? 235 ILE A HG21 1 
ATOM   3019 H  HG22 . ILE A 1 235 ? 21.32100 28.41000  10.79900 1.000 35.57246  ? 235 ILE A HG22 1 
ATOM   3020 H  HG23 . ILE A 1 235 ? 22.12100 27.25400  11.53900 1.000 35.57246  ? 235 ILE A HG23 1 
ATOM   3021 H  HD11 . ILE A 1 235 ? 20.93900 23.65900  11.30400 1.000 53.05016  ? 235 ILE A HD11 1 
ATOM   3022 H  HD12 . ILE A 1 235 ? 20.71100 24.71800  10.14200 1.000 53.05016  ? 235 ILE A HD12 1 
ATOM   3023 H  HD13 . ILE A 1 235 ? 22.00300 24.81300  11.06100 1.000 53.05016  ? 235 ILE A HD13 1 
ATOM   3024 N  N    . LEU A 1 236 ? 18.23900 29.50900  11.45800 1.000 32.08916  ? 236 LEU A N    1 
ATOM   3025 C  CA   . LEU A 1 236 ? 18.02500 30.77500  10.76800 1.000 35.41043  ? 236 LEU A CA   1 
ATOM   3026 C  C    . LEU A 1 236 ? 17.13200 31.74500  11.53400 1.000 34.94158  ? 236 LEU A C    1 
ATOM   3027 O  O    . LEU A 1 236 ? 16.94100 32.87700  11.07700 1.000 39.36597  ? 236 LEU A O    1 
ATOM   3028 C  CB   . LEU A 1 236 ? 17.43100 30.50800  9.38000  1.000 35.35574  ? 236 LEU A CB   1 
ATOM   3029 C  CG   . LEU A 1 236 ? 18.29800 29.66600  8.43700  1.000 26.20217  ? 236 LEU A CG   1 
ATOM   3030 C  CD1  . LEU A 1 236 ? 17.58000 29.42700  7.11600  1.000 34.62773  ? 236 LEU A CD1  1 
ATOM   3031 C  CD2  . LEU A 1 236 ? 19.65300 30.32800  8.19600  1.000 33.66373  ? 236 LEU A CD2  1 
ATOM   3032 H  H    . LEU A 1 236 ? 17.57800 28.96200  11.39000 1.000 38.44675  ? 236 LEU A H    1 
ATOM   3033 H  HA   . LEU A 1 236 ? 18.88400 31.21100  10.65500 1.000 42.43228  ? 236 LEU A HA   1 
ATOM   3034 H  HB2  . LEU A 1 236 ? 16.58900 30.03900  9.49400  1.000 42.36664  ? 236 LEU A HB2  1 
ATOM   3035 H  HB3  . LEU A 1 236 ? 17.27800 31.36200  8.94600  1.000 42.36664  ? 236 LEU A HB3  1 
ATOM   3036 H  HG   . LEU A 1 236 ? 18.45900 28.80600  8.85500  1.000 31.38237  ? 236 LEU A HG   1 
ATOM   3037 H  HD11 . LEU A 1 236 ? 18.16400 28.92600  6.52600  1.000 41.49303  ? 236 LEU A HD11 1 
ATOM   3038 H  HD12 . LEU A 1 236 ? 16.76800 28.92400  7.28500  1.000 41.49303  ? 236 LEU A HD12 1 
ATOM   3039 H  HD13 . LEU A 1 236 ? 17.36100 30.28400  6.71700  1.000 41.49303  ? 236 LEU A HD13 1 
ATOM   3040 H  HD21 . LEU A 1 236 ? 20.11200 29.85600  7.48300  1.000 40.33624  ? 236 LEU A HD21 1 
ATOM   3041 H  HD22 . LEU A 1 236 ? 19.51200 31.25400  7.94300  1.000 40.33624  ? 236 LEU A HD22 1 
ATOM   3042 H  HD23 . LEU A 1 236 ? 20.17500 30.28400  9.01200  1.000 40.33624  ? 236 LEU A HD23 1 
ATOM   3043 N  N    . GLY A 1 237 ? 16.58700 31.34300  12.68200 1.000 37.23929  ? 237 GLY A N    1 
ATOM   3044 C  CA   . GLY A 1 237 ? 15.78300 32.23800  13.49400 1.000 33.18332  ? 237 GLY A CA   1 
ATOM   3045 C  C    . GLY A 1 237 ? 14.44200 32.56800  12.87200 1.000 46.68581  ? 237 GLY A C    1 
ATOM   3046 O  O    . GLY A 1 237 ? 14.05600 33.73700  12.79000 1.000 44.09250  ? 237 GLY A O    1 
ATOM   3047 H  H    . GLY A 1 237 ? 16.67200 30.55200  13.01000 1.000 44.62691  ? 237 GLY A H    1 
ATOM   3048 H  HA2  . GLY A 1 237 ? 15.62200 31.82600  14.35700 1.000 39.75974  ? 237 GLY A HA2  1 
ATOM   3049 H  HA3  . GLY A 1 237 ? 16.26700 33.06800  13.62500 1.000 39.75974  ? 237 GLY A HA3  1 
ATOM   3050 N  N    . MET A 1 238 ? 13.70700 31.53600  12.45600 1.000 32.03372  ? 238 MET A N    1 
ATOM   3051 C  CA   . MET A 1 238 ? 12.54000 31.71100  11.60500 1.000 38.79132  ? 238 MET A CA   1 
ATOM   3052 C  C    . MET A 1 238 ? 11.21100 31.69800  12.34400 1.000 37.44513  ? 238 MET A C    1 
ATOM   3053 O  O    . MET A 1 238 ? 10.22400 32.21800  11.81400 1.000 64.54717  ? 238 MET A O    1 
ATOM   3054 C  CB   . MET A 1 238 ? 12.48800 30.59500  10.55900 1.000 42.23041  ? 238 MET A CB   1 
ATOM   3055 C  CG   . MET A 1 238 ? 13.09200 30.93300  9.22800  1.000 51.27909  ? 238 MET A CG   1 
ATOM   3056 S  SD   . MET A 1 238 ? 13.08900 29.46200  8.19600  1.000 47.09285  ? 238 MET A SD   1 
ATOM   3057 C  CE   . MET A 1 238 ? 11.51200 29.66500  7.36300  1.000 56.62282  ? 238 MET A CE   1 
ATOM   3058 H  H    . MET A 1 238 ? 13.86900 30.71600  12.65800 1.000 38.38023  ? 238 MET A H    1 
ATOM   3059 H  HA   . MET A 1 238 ? 12.63600 32.56800  11.16100 1.000 46.48934  ? 238 MET A HA   1 
ATOM   3060 H  HB2  . MET A 1 238 ? 12.96800 29.82700  10.90800 1.000 50.61626  ? 238 MET A HB2  1 
ATOM   3061 H  HB3  . MET A 1 238 ? 11.55900 30.36300  10.40500 1.000 50.61626  ? 238 MET A HB3  1 
ATOM   3062 H  HG2  . MET A 1 238 ? 12.56900 31.62500  8.79400  1.000 61.47467  ? 238 MET A HG2  1 
ATOM   3063 H  HG3  . MET A 1 238 ? 14.00600 31.23400  9.34700  1.000 61.47467  ? 238 MET A HG3  1 
ATOM   3064 H  HE1  . MET A 1 238 ? 11.35900 28.90100  6.78600  1.000 67.88715  ? 238 MET A HE1  1 
ATOM   3065 H  HE2  . MET A 1 238 ? 10.80900 29.72400  8.02800  1.000 67.88715  ? 238 MET A HE2  1 
ATOM   3066 H  HE3  . MET A 1 238 ? 11.53700 30.47800  6.83500  1.000 67.88715  ? 238 MET A HE3  1 
ATOM   3067 N  N    . GLY A 1 239 ? 11.14900 31.11200  13.52600 1.000 38.65545  ? 239 GLY A N    1 
ATOM   3068 C  CA   . GLY A 1 239 ? 9.87800  30.67400  14.05200 1.000 50.23042  ? 239 GLY A CA   1 
ATOM   3069 C  C    . GLY A 1 239 ? 9.47400  29.34600  13.43800 1.000 45.01166  ? 239 GLY A C    1 
ATOM   3070 O  O    . GLY A 1 239 ? 9.96700  28.93300  12.38700 1.000 37.42444  ? 239 GLY A O    1 
ATOM   3071 H  H    . GLY A 1 239 ? 11.82400 30.96000  14.03700 1.000 46.32630  ? 239 GLY A H    1 
ATOM   3072 H  HA2  . GLY A 1 239 ? 9.94000  30.56800  15.01400 1.000 60.21626  ? 239 GLY A HA2  1 
ATOM   3073 H  HA3  . GLY A 1 239 ? 9.19500  31.33300  13.85000 1.000 60.21626  ? 239 GLY A HA3  1 
ATOM   3074 N  N    . TYR A 1 240 ? 8.54900  28.66800  14.10400 1.000 41.07471  ? 240 TYR A N    1 
ATOM   3075 C  CA   . TYR A 1 240 ? 8.47000  27.22500  13.94800 1.000 38.30599  ? 240 TYR A CA   1 
ATOM   3076 C  C    . TYR A 1 240 ? 7.07900  26.73300  14.31300 1.000 43.02334  ? 240 TYR A C    1 
ATOM   3077 O  O    . TYR A 1 240 ? 6.24800  27.47400  14.84100 1.000 40.64932  ? 240 TYR A O    1 
ATOM   3078 C  CB   . TYR A 1 240 ? 9.52600  26.55900  14.83000 1.000 40.07769  ? 240 TYR A CB   1 
ATOM   3079 C  CG   . TYR A 1 240 ? 9.36400  26.95400  16.28100 1.000 37.02278  ? 240 TYR A CG   1 
ATOM   3080 C  CD1  . TYR A 1 240 ? 8.50700  26.25400  17.11700 1.000 32.81326  ? 240 TYR A CD1  1 
ATOM   3081 C  CD2  . TYR A 1 240 ? 10.02700 28.06100  16.80000 1.000 42.38851  ? 240 TYR A CD2  1 
ATOM   3082 C  CE1  . TYR A 1 240 ? 8.34100  26.61800  18.43700 1.000 40.00602  ? 240 TYR A CE1  1 
ATOM   3083 C  CE2  . TYR A 1 240 ? 9.86400  28.43800  18.12400 1.000 38.01112  ? 240 TYR A CE2  1 
ATOM   3084 C  CZ   . TYR A 1 240 ? 9.01800  27.71000  18.93600 1.000 35.02791  ? 240 TYR A CZ   1 
ATOM   3085 O  OH   . TYR A 1 240 ? 8.84400  28.06700  20.25300 1.000 42.81488  ? 240 TYR A OH   1 
ATOM   3086 H  H    . TYR A 1 240 ? 7.97100  29.01300  14.63900 1.000 49.22941  ? 240 TYR A H    1 
ATOM   3087 H  HA   . TYR A 1 240 ? 8.61300  26.99600  13.01600 1.000 45.90695  ? 240 TYR A HA   1 
ATOM   3088 H  HB2  . TYR A 1 240 ? 9.43700  25.59500  14.76400 1.000 48.03300  ? 240 TYR A HB2  1 
ATOM   3089 H  HB3  . TYR A 1 240 ? 10.40900 26.83100  14.53500 1.000 48.03300  ? 240 TYR A HB3  1 
ATOM   3090 H  HD1  . TYR A 1 240 ? 8.03700  25.52500  16.78200 1.000 39.31567  ? 240 TYR A HD1  1 
ATOM   3091 H  HD2  . TYR A 1 240 ? 10.59000 28.55700  16.25000 1.000 50.80598  ? 240 TYR A HD2  1 
ATOM   3092 H  HE1  . TYR A 1 240 ? 7.77300  26.12900  18.98900 1.000 47.94699  ? 240 TYR A HE1  1 
ATOM   3093 H  HE2  . TYR A 1 240 ? 10.32000 29.17400  18.46100 1.000 45.55311  ? 240 TYR A HE2  1 
ATOM   3094 H  HH   . TYR A 1 240 ? 9.33800  28.72000  20.44100 1.000 51.31761  ? 240 TYR A HH   1 
ATOM   3095 N  N    . LYS A 1 241 ? 6.84500  25.45700  14.01800 1.000 39.46994  ? 241 LYS A N    1 
ATOM   3096 C  CA   . LYS A 1 241 ? 5.67300  24.73500  14.48600 1.000 33.45001  ? 241 LYS A CA   1 
ATOM   3097 C  C    . LYS A 1 241 ? 6.14200  23.34600  14.91700 1.000 36.62692  ? 241 LYS A C    1 
ATOM   3098 O  O    . LYS A 1 241 ? 7.34500  23.08300  15.01800 1.000 27.65783  ? 241 LYS A O    1 
ATOM   3099 C  CB   . LYS A 1 241 ? 4.58200  24.71100  13.40800 1.000 29.74896  ? 241 LYS A CB   1 
ATOM   3100 C  CG   . LYS A 1 241 ? 5.02800  24.18800  12.05000 1.000 40.63507  ? 241 LYS A CG   1 
ATOM   3101 C  CD   . LYS A 1 241 ? 3.83800  23.68200  11.24400 1.000 43.41579  ? 241 LYS A CD   1 
ATOM   3102 C  CE   . LYS A 1 241 ? 4.24600  23.24500  9.84300  1.000 43.71890  ? 241 LYS A CE   1 
ATOM   3103 N  NZ   . LYS A 1 241 ? 4.24300  24.38000  8.87300  1.000 59.25857  ? 241 LYS A NZ   1 
ATOM   3104 H  H    . LYS A 1 241 ? 7.36700  24.97600  13.53300 1.000 47.30369  ? 241 LYS A H    1 
ATOM   3105 H  HA   . LYS A 1 241 ? 5.29800  25.18200  15.26100 1.000 40.07978  ? 241 LYS A HA   1 
ATOM   3106 H  HB2  . LYS A 1 241 ? 3.85900  24.14200  13.71500 1.000 35.63851  ? 241 LYS A HB2  1 
ATOM   3107 H  HB3  . LYS A 1 241 ? 4.25800  25.61600  13.27900 1.000 35.63851  ? 241 LYS A HB3  1 
ATOM   3108 H  HG2  . LYS A 1 241 ? 5.45500  24.90300  11.55300 1.000 48.70184  ? 241 LYS A HG2  1 
ATOM   3109 H  HG3  . LYS A 1 241 ? 5.64900  23.45400  12.17500 1.000 48.70184  ? 241 LYS A HG3  1 
ATOM   3110 H  HD2  . LYS A 1 241 ? 3.44600  22.92000  11.69700 1.000 52.03871  ? 241 LYS A HD2  1 
ATOM   3111 H  HD3  . LYS A 1 241 ? 3.18300  24.39300  11.16100 1.000 52.03871  ? 241 LYS A HD3  1 
ATOM   3112 H  HE2  . LYS A 1 241 ? 5.14300  22.87700  9.87300  1.000 52.40245  ? 241 LYS A HE2  1 
ATOM   3113 H  HE3  . LYS A 1 241 ? 3.62200  22.57400  9.52500  1.000 52.40245  ? 241 LYS A HE3  1 
ATOM   3114 H  HZ1  . LYS A 1 241 ? 4.47800  24.09100  8.06500  1.000 71.05005  ? 241 LYS A HZ1  1 
ATOM   3115 H  HZ2  . LYS A 1 241 ? 3.42900  24.73800  8.82700  1.000 71.05005  ? 241 LYS A HZ2  1 
ATOM   3116 H  HZ3  . LYS A 1 241 ? 4.81900  25.00600  9.13500  1.000 71.05005  ? 241 LYS A HZ3  1 
ATOM   3117 N  N    . GLU A 1 242 ? 5.18800  22.44800  15.16900 1.000 35.31196  ? 242 GLU A N    1 
ATOM   3118 C  CA   . GLU A 1 242 ? 5.52200  21.17500  15.80300 1.000 37.28245  ? 242 GLU A CA   1 
ATOM   3119 C  C    . GLU A 1 242 ? 6.54700  20.38800  14.99200 1.000 33.54098  ? 242 GLU A C    1 
ATOM   3120 O  O    . GLU A 1 242 ? 7.44000  19.75200  15.56400 1.000 32.92646  ? 242 GLU A O    1 
ATOM   3121 C  CB   . GLU A 1 242 ? 4.25400  20.34600  16.00800 1.000 39.03078  ? 242 GLU A CB   1 
ATOM   3122 C  CG   . GLU A 1 242 ? 3.52500  20.64000  17.31100 1.000 46.47003  ? 242 GLU A CG   1 
ATOM   3123 C  CD   . GLU A 1 242 ? 2.47200  21.72200  17.16400 1.000 49.33447  ? 242 GLU A CD   1 
ATOM   3124 O  OE1  . GLU A 1 242 ? 2.60700  22.56600  16.25200 1.000 42.24191  ? 242 GLU A OE1  1 
ATOM   3125 O  OE2  . GLU A 1 242 ? 1.51000  21.72800  17.96200 1.000 55.45860  ? 242 GLU A OE2  1 
ATOM   3126 H  H    . GLU A 1 242 ? 4.35400  22.55000  14.98600 1.000 42.31412  ? 242 GLU A H    1 
ATOM   3127 H  HA   . GLU A 1 242 ? 5.91300  21.36000  16.67100 1.000 44.67871  ? 242 GLU A HA   1 
ATOM   3128 H  HB2  . GLU A 1 242 ? 3.64100  20.53000  15.27900 1.000 46.77670  ? 242 GLU A HB2  1 
ATOM   3129 H  HB3  . GLU A 1 242 ? 4.49400  19.40600  16.01000 1.000 46.77670  ? 242 GLU A HB3  1 
ATOM   3130 H  HG2  . GLU A 1 242 ? 3.08400  19.83200  17.61600 1.000 55.70380  ? 242 GLU A HG2  1 
ATOM   3131 H  HG3  . GLU A 1 242 ? 4.16900  20.93700  17.97300 1.000 55.70380  ? 242 GLU A HG3  1 
ATOM   3132 N  N    . ASN A 1 243 ? 6.44300  20.41700  13.66300 1.000 28.71302  ? 243 ASN A N    1 
ATOM   3133 C  CA   . ASN A 1 243 ? 7.34100  19.59400  12.84800 1.000 28.34567  ? 243 ASN A CA   1 
ATOM   3134 C  C    . ASN A 1 243 ? 8.78400  20.11500  12.82200 1.000 24.11662  ? 243 ASN A C    1 
ATOM   3135 O  O    . ASN A 1 243 ? 9.59700  19.56500  12.06700 1.000 26.73082  ? 243 ASN A O    1 
ATOM   3136 C  CB   . ASN A 1 243 ? 6.78700  19.46500  11.42500 1.000 32.33870  ? 243 ASN A CB   1 
ATOM   3137 C  CG   . ASN A 1 243 ? 7.06100  20.68400  10.56500 1.000 36.47207  ? 243 ASN A CG   1 
ATOM   3138 O  OD1  . ASN A 1 243 ? 7.39200  21.75800  11.06400 1.000 35.61400  ? 243 ASN A OD1  1 
ATOM   3139 N  ND2  . ASN A 1 243 ? 6.91100  20.52000  9.25400  1.000 39.84666  ? 243 ASN A ND2  1 
ATOM   3140 H  H    . ASN A 1 243 ? 5.87700  20.89100  13.22100 1.000 34.39539  ? 243 ASN A H    1 
ATOM   3141 H  HA   . ASN A 1 243 ? 7.37200  18.70300  13.23000 1.000 33.95456  ? 243 ASN A HA   1 
ATOM   3142 H  HB2  . ASN A 1 243 ? 7.19800  18.69900  10.99500 1.000 38.74620  ? 243 ASN A HB2  1 
ATOM   3143 H  HB3  . ASN A 1 243 ? 5.82500  19.34400  11.47100 1.000 38.74620  ? 243 ASN A HB3  1 
ATOM   3144 H  HD21 . ASN A 1 243 ? 6.67100  19.75600  8.94100  1.000 47.75575  ? 243 ASN A HD21 1 
ATOM   3145 H  HD22 . ASN A 1 243 ? 7.05300  21.17900  8.71900  1.000 47.75575  ? 243 ASN A HD22 1 
ATOM   3146 N  N    . VAL A 1 244 ? 9.14900  21.13100  13.60800 1.000 24.52375  ? 244 VAL A N    1 
ATOM   3147 C  CA   . VAL A 1 244 ? 10.56100 21.46500  13.76600 1.000 27.66123  ? 244 VAL A CA   1 
ATOM   3148 C  C    . VAL A 1 244 ? 11.31900 20.27800  14.34600 1.000 23.76616  ? 244 VAL A C    1 
ATOM   3149 O  O    . VAL A 1 244 ? 12.49200 20.05500  14.01800 1.000 24.54446  ? 244 VAL A O    1 
ATOM   3150 C  CB   . VAL A 1 244 ? 10.71900 22.72200  14.64600 1.000 27.00763  ? 244 VAL A CB   1 
ATOM   3151 C  CG1  . VAL A 1 244 ? 10.24600 22.45300  16.07200 1.000 26.59290  ? 244 VAL A CG1  1 
ATOM   3152 C  CG2  . VAL A 1 244 ? 12.16000 23.20600  14.63800 1.000 29.92544  ? 244 VAL A CG2  1 
ATOM   3153 H  H    . VAL A 1 244 ? 8.60800  21.63200  14.05000 1.000 29.36827  ? 244 VAL A H    1 
ATOM   3154 H  HA   . VAL A 1 244 ? 10.93500 21.66700  12.89400 1.000 33.13324  ? 244 VAL A HA   1 
ATOM   3155 H  HB   . VAL A 1 244 ? 10.16300 23.42700  14.27800 1.000 32.34892  ? 244 VAL A HB   1 
ATOM   3156 H  HG11 . VAL A 1 244 ? 10.20000 23.29400  16.55300 1.000 31.85124  ? 244 VAL A HG11 1 
ATOM   3157 H  HG12 . VAL A 1 244 ? 9.36900  22.04000  16.04100 1.000 31.85124  ? 244 VAL A HG12 1 
ATOM   3158 H  HG13 . VAL A 1 244 ? 10.87700 21.85800  16.50600 1.000 31.85124  ? 244 VAL A HG13 1 
ATOM   3159 H  HG21 . VAL A 1 244 ? 12.23800 23.97500  15.22400 1.000 35.85029  ? 244 VAL A HG21 1 
ATOM   3160 H  HG22 . VAL A 1 244 ? 12.73500 22.49100  14.95300 1.000 35.85029  ? 244 VAL A HG22 1 
ATOM   3161 H  HG23 . VAL A 1 244 ? 12.40500 23.45400  13.73300 1.000 35.85029  ? 244 VAL A HG23 1 
ATOM   3162 N  N    . ASP A 1 245 ? 10.66600 19.49300  15.20300 1.000 22.60816  ? 245 ASP A N    1 
ATOM   3163 C  CA   . ASP A 1 245 ? 11.31800 18.34300  15.81900 1.000 24.91890  ? 245 ASP A CA   1 
ATOM   3164 C  C    . ASP A 1 245 ? 11.47000 17.16800  14.85800 1.000 23.23576  ? 245 ASP A C    1 
ATOM   3165 O  O    . ASP A 1 245 ? 12.30100 16.29000  15.10600 1.000 26.81150  ? 245 ASP A O    1 
ATOM   3166 C  CB   . ASP A 1 245 ? 10.53500 17.89800  17.05700 1.000 28.10595  ? 245 ASP A CB   1 
ATOM   3167 C  CG   . ASP A 1 245 ? 10.59400 18.91600  18.18100 1.000 31.66171  ? 245 ASP A CG   1 
ATOM   3168 O  OD1  . ASP A 1 245 ? 11.68500 19.48200  18.41400 1.000 28.07186  ? 245 ASP A OD1  1 
ATOM   3169 O  OD2  . ASP A 1 245 ? 9.55600  19.14400  18.84100 1.000 31.09005  ? 245 ASP A OD2  1 
ATOM   3170 H  H    . ASP A 1 245 ? 9.84800  19.60700  15.44200 1.000 27.06956  ? 245 ASP A H    1 
ATOM   3171 H  HA   . ASP A 1 245 ? 12.20700 18.60500  16.10600 1.000 29.84244  ? 245 ASP A HA   1 
ATOM   3172 H  HB2  . ASP A 1 245 ? 9.60500  17.77200  16.81500 1.000 33.66690  ? 245 ASP A HB2  1 
ATOM   3173 H  HB3  . ASP A 1 245 ? 10.90900 17.06600  17.38600 1.000 33.66690  ? 245 ASP A HB3  1 
ATOM   3174 N  N    . ILE A 1 246 ? 10.70000 17.13300  13.77000 1.000 25.02125  ? 246 ILE A N    1 
ATOM   3175 C  CA   . ILE A 1 246 ? 10.85300 16.05600  12.79300 1.000 26.09213  ? 246 ILE A CA   1 
ATOM   3176 C  C    . ILE A 1 246 ? 12.22500 16.13000  12.13000 1.000 25.39285  ? 246 ILE A C    1 
ATOM   3177 O  O    . ILE A 1 246 ? 12.85000 15.10100  11.84800 1.000 23.33923  ? 246 ILE A O    1 
ATOM   3178 C  CB   . ILE A 1 246 ? 9.71300  16.11100  11.75800 1.000 27.08226  ? 246 ILE A CB   1 
ATOM   3179 C  CG1  . ILE A 1 246 ? 8.41100  15.58200  12.37200 1.000 29.23405  ? 246 ILE A CG1  1 
ATOM   3180 C  CG2  . ILE A 1 246 ? 10.07600 15.32600  10.51300 1.000 26.69932  ? 246 ILE A CG2  1 
ATOM   3181 C  CD1  . ILE A 1 246 ? 8.40700  14.07400  12.63900 1.000 27.44383  ? 246 ILE A CD1  1 
ATOM   3182 H  H    . ILE A 1 246 ? 10.09200 17.71000  13.57600 1.000 29.96527  ? 246 ILE A H    1 
ATOM   3183 H  HA   . ILE A 1 246 ? 10.79400 15.20500  13.25600 1.000 31.25032  ? 246 ILE A HA   1 
ATOM   3184 H  HB   . ILE A 1 246 ? 9.58000  17.03700  11.50300 1.000 32.43848  ? 246 ILE A HB   1 
ATOM   3185 H  HG12 . ILE A 1 246 ? 8.26300  16.03100  13.21900 1.000 35.02062  ? 246 ILE A HG12 1 
ATOM   3186 H  HG13 . ILE A 1 246 ? 7.68100  15.77400  11.76300 1.000 35.02062  ? 246 ILE A HG13 1 
ATOM   3187 H  HG21 . ILE A 1 246 ? 9.27200  15.17200  9.99200  1.000 31.97894  ? 246 ILE A HG21 1 
ATOM   3188 H  HG22 . ILE A 1 246 ? 10.71500 15.83800  9.99300  1.000 31.97894  ? 246 ILE A HG22 1 
ATOM   3189 H  HG23 . ILE A 1 246 ? 10.46700 14.47900  10.77600 1.000 31.97894  ? 246 ILE A HG23 1 
ATOM   3190 H  HD11 . ILE A 1 246 ? 7.62200  13.84800  13.16200 1.000 32.87235  ? 246 ILE A HD11 1 
ATOM   3191 H  HD12 . ILE A 1 246 ? 8.38800  13.60300  11.79200 1.000 32.87235  ? 246 ILE A HD12 1 
ATOM   3192 H  HD13 . ILE A 1 246 ? 9.21000  13.83800  13.13000 1.000 32.87235  ? 246 ILE A HD13 1 
ATOM   3193 N  N    . TRP A 1 247 ? 12.71900 17.34500  11.87800 1.000 21.34489  ? 247 TRP A N    1 
ATOM   3194 C  CA   . TRP A 1 247 ? 14.06000 17.49600  11.32500 1.000 20.83783  ? 247 TRP A CA   1 
ATOM   3195 C  C    . TRP A 1 247 ? 15.09200 16.77400  12.17900 1.000 22.25920  ? 247 TRP A C    1 
ATOM   3196 O  O    . TRP A 1 247 ? 15.94800 16.04700  11.66400 1.000 22.23921  ? 247 TRP A O    1 
ATOM   3197 C  CB   . TRP A 1 247 ? 14.42000 18.97500  11.21700 1.000 18.47592  ? 247 TRP A CB   1 
ATOM   3198 C  CG   . TRP A 1 247 ? 15.81500 19.21000  10.72000 1.000 21.52662  ? 247 TRP A CG   1 
ATOM   3199 C  CD1  . TRP A 1 247 ? 16.95600 19.27300  11.46900 1.000 21.63916  ? 247 TRP A CD1  1 
ATOM   3200 C  CD2  . TRP A 1 247 ? 16.21600 19.41300  9.36000  1.000 20.98031  ? 247 TRP A CD2  1 
ATOM   3201 N  NE1  . TRP A 1 247 ? 18.04100 19.51200  10.65700 1.000 22.08124  ? 247 TRP A NE1  1 
ATOM   3202 C  CE2  . TRP A 1 247 ? 17.61400 19.59800  9.35900  1.000 20.43328  ? 247 TRP A CE2  1 
ATOM   3203 C  CE3  . TRP A 1 247 ? 15.52900 19.45900  8.14300  1.000 25.19014  ? 247 TRP A CE3  1 
ATOM   3204 C  CZ2  . TRP A 1 247 ? 18.33600 19.82900  8.18800  1.000 25.35094  ? 247 TRP A CZ2  1 
ATOM   3205 C  CZ3  . TRP A 1 247 ? 16.24700 19.68700  6.98100  1.000 24.30971  ? 247 TRP A CZ3  1 
ATOM   3206 C  CH2  . TRP A 1 247 ? 17.63600 19.86800  7.01200  1.000 24.63587  ? 247 TRP A CH2  1 
ATOM   3207 H  H    . TRP A 1 247 ? 12.30300 18.08400  12.01800 1.000 25.55363  ? 247 TRP A H    1 
ATOM   3208 H  HA   . TRP A 1 247 ? 14.06900 17.11100  10.43500 1.000 24.94516  ? 247 TRP A HA   1 
ATOM   3209 H  HB2  . TRP A 1 247 ? 13.80700 19.40300  10.59800 1.000 22.11086  ? 247 TRP A HB2  1 
ATOM   3210 H  HB3  . TRP A 1 247 ? 14.34300 19.38100  12.09400 1.000 22.11086  ? 247 TRP A HB3  1 
ATOM   3211 H  HD1  . TRP A 1 247 ? 16.99400 19.16900  12.39200 1.000 25.90675  ? 247 TRP A HD1  1 
ATOM   3212 H  HE1  . TRP A 1 247 ? 18.85500 19.59400  10.92200 1.000 26.43725  ? 247 TRP A HE1  1 
ATOM   3213 H  HE3  . TRP A 1 247 ? 14.60700 19.33800  8.11400  1.000 30.16793  ? 247 TRP A HE3  1 
ATOM   3214 H  HZ2  . TRP A 1 247 ? 19.25800 19.95200  8.20600  1.000 30.36089  ? 247 TRP A HZ2  1 
ATOM   3215 H  HZ3  . TRP A 1 247 ? 15.80100 19.72000  6.16600  1.000 29.11141  ? 247 TRP A HZ3  1 
ATOM   3216 H  HH2  . TRP A 1 247 ? 18.09300 20.01800  6.21600  1.000 29.50281  ? 247 TRP A HH2  1 
ATOM   3217 N  N    . SER A 1 248 ? 15.03500 16.98200  13.49600 1.000 22.42088  ? 248 SER A N    1 
ATOM   3218 C  CA   . SER A 1 248 ? 16.02200 16.37300  14.37900 1.000 23.63883  ? 248 SER A CA   1 
ATOM   3219 C  C    . SER A 1 248 ? 15.93500 14.85400  14.33500 1.000 22.14917  ? 248 SER A C    1 
ATOM   3220 O  O    . SER A 1 248 ? 16.96100 14.16500  14.37800 1.000 20.10055  ? 248 SER A O    1 
ATOM   3221 C  CB   . SER A 1 248 ? 15.82400 16.88200  15.80700 1.000 21.34772  ? 248 SER A CB   1 
ATOM   3222 O  OG   . SER A 1 248 ? 15.69100 18.29400  15.82800 1.000 23.72422  ? 248 SER A OG   1 
ATOM   3223 H  H    . SER A 1 248 ? 14.44300 17.46300  13.89400 1.000 26.84482  ? 248 SER A H    1 
ATOM   3224 H  HA   . SER A 1 248 ? 16.91000 16.63200  14.08700 1.000 28.30635  ? 248 SER A HA   1 
ATOM   3225 H  HB2  . SER A 1 248 ? 15.01900 16.48400  16.17500 1.000 25.55703  ? 248 SER A HB2  1 
ATOM   3226 H  HB3  . SER A 1 248 ? 16.59300 16.62900  16.34100 1.000 25.55703  ? 248 SER A HB3  1 
ATOM   3227 H  HG   . SER A 1 248 ? 16.39800 18.65300  15.55200 1.000 28.40882  ? 248 SER A HG   1 
ATOM   3228 N  N    . VAL A 1 249 ? 14.71800 14.31400  14.26100 1.000 19.59641  ? 249 VAL A N    1 
ATOM   3229 C  CA   . VAL A 1 249 ? 14.55800 12.86800  14.12000 1.000 23.05089  ? 249 VAL A CA   1 
ATOM   3230 C  C    . VAL A 1 249 ? 15.19000 12.39200  12.82000 1.000 26.48552  ? 249 VAL A C    1 
ATOM   3231 O  O    . VAL A 1 249 ? 15.85100 11.34700  12.77700 1.000 20.70298  ? 249 VAL A O    1 
ATOM   3232 C  CB   . VAL A 1 249 ? 13.06900 12.48700  14.20000 1.000 24.61575  ? 249 VAL A CB   1 
ATOM   3233 C  CG1  . VAL A 1 249 ? 12.88300 10.99900  13.93600 1.000 33.27609  ? 249 VAL A CG1  1 
ATOM   3234 C  CG2  . VAL A 1 249 ? 12.50600 12.86200  15.56100 1.000 26.39321  ? 249 VAL A CG2  1 
ATOM   3235 H  H    . VAL A 1 249 ? 13.98100 14.75500  14.29000 1.000 23.45545  ? 249 VAL A H    1 
ATOM   3236 H  HA   . VAL A 1 249 ? 15.01800 12.43100  14.85500 1.000 27.60083  ? 249 VAL A HA   1 
ATOM   3237 H  HB   . VAL A 1 249 ? 12.58000 12.97500  13.51900 1.000 29.47866  ? 249 VAL A HB   1 
ATOM   3238 H  HG11 . VAL A 1 249 ? 11.97900 10.74600  14.18000 1.000 39.87107  ? 249 VAL A HG11 1 
ATOM   3239 H  HG12 . VAL A 1 249 ? 13.03300 10.82400  12.99400 1.000 39.87107  ? 249 VAL A HG12 1 
ATOM   3240 H  HG13 . VAL A 1 249 ? 13.52200 10.50100  14.47000 1.000 39.87107  ? 249 VAL A HG13 1 
ATOM   3241 H  HG21 . VAL A 1 249 ? 11.58700 12.55800  15.61800 1.000 31.61161  ? 249 VAL A HG21 1 
ATOM   3242 H  HG22 . VAL A 1 249 ? 13.03800 12.43600  16.25100 1.000 31.61161  ? 249 VAL A HG22 1 
ATOM   3243 H  HG23 . VAL A 1 249 ? 12.54200 13.82600  15.66300 1.000 31.61161  ? 249 VAL A HG23 1 
ATOM   3244 N  N    . GLY A 1 250 ? 14.99900 13.14900  11.73900 1.000 27.18998  ? 250 GLY A N    1 
ATOM   3245 C  CA   . GLY A 1 250 ? 15.64300 12.79800  10.48500 1.000 27.16604  ? 250 GLY A CA   1 
ATOM   3246 C  C    . GLY A 1 250 ? 17.15500 12.83600  10.58500 1.000 30.06900  ? 250 GLY A C    1 
ATOM   3247 O  O    . GLY A 1 250 ? 17.84800 12.00900  9.98700  1.000 25.47847  ? 250 GLY A O    1 
ATOM   3248 H  H    . GLY A 1 250 ? 14.51000 13.85600  11.70900 1.000 32.56774  ? 250 GLY A H    1 
ATOM   3249 H  HA2  . GLY A 1 250 ? 15.37600 11.90200  10.22600 1.000 32.53901  ? 250 GLY A HA2  1 
ATOM   3250 H  HA3  . GLY A 1 250 ? 15.36600 13.42200  9.79600  1.000 32.53901  ? 250 GLY A HA3  1 
ATOM   3251 N  N    . CYS A 1 251 ? 17.69000 13.79900  11.34300 1.000 21.26552  ? 251 CYS A N    1 
ATOM   3252 C  CA   . CYS A 1 251 ? 19.13400 13.86000  11.53900 1.000 17.83964  ? 251 CYS A CA   1 
ATOM   3253 C  C    . CYS A 1 251 ? 19.62600 12.64700  12.31700 1.000 18.47507  ? 251 CYS A C    1 
ATOM   3254 O  O    . CYS A 1 251 ? 20.68200 12.08500  12.00400 1.000 21.70963  ? 251 CYS A O    1 
ATOM   3255 C  CB   . CYS A 1 251 ? 19.51400 15.14900  12.26600 1.000 21.31461  ? 251 CYS A CB   1 
ATOM   3256 S  SG   . CYS A 1 251 ? 19.33300 16.66100  11.29700 1.000 24.48427  ? 251 CYS A SG   1 
ATOM   3257 H  H    . CYS A 1 251 ? 17.24500 14.41500  11.74500 1.000 25.45839  ? 251 CYS A H    1 
ATOM   3258 H  HA   . CYS A 1 251 ? 19.57000 13.86800  10.67300 1.000 21.34733  ? 251 CYS A HA   1 
ATOM   3259 H  HB2  . CYS A 1 251 ? 18.94700 15.23700  13.04900 1.000 25.51730  ? 251 CYS A HB2  1 
ATOM   3260 H  HB3  . CYS A 1 251 ? 20.44400 15.08700  12.53500 1.000 25.51730  ? 251 CYS A HB3  1 
ATOM   3261 H  HG   . CYS A 1 251 ? 19.65900 17.59900  11.97100 1.000 29.32089  ? 251 CYS A HG   1 
ATOM   3262 N  N    . ILE A 1 252 ? 18.87400 12.23700  13.34100 1.000 23.18444  ? 252 ILE A N    1 
ATOM   3263 C  CA   . ILE A 1 252 ? 19.20900 11.02200  14.08000 1.000 22.38643  ? 252 ILE A CA   1 
ATOM   3264 C  C    . ILE A 1 252 ? 19.09400 9.80600   13.17000 1.000 25.92049  ? 252 ILE A C    1 
ATOM   3265 O  O    . ILE A 1 252 ? 20.01800 8.98700   13.07900 1.000 23.36982  ? 252 ILE A O    1 
ATOM   3266 C  CB   . ILE A 1 252 ? 18.30500 10.88800  15.32100 1.000 19.42802  ? 252 ILE A CB   1 
ATOM   3267 C  CG1  . ILE A 1 252 ? 18.57400 12.04700  16.28600 1.000 23.70777  ? 252 ILE A CG1  1 
ATOM   3268 C  CG2  . ILE A 1 252 ? 18.51300 9.52300   15.98100 1.000 25.89478  ? 252 ILE A CG2  1 
ATOM   3269 C  CD1  . ILE A 1 252 ? 17.63000 12.11000  17.47200 1.000 28.79036  ? 252 ILE A CD1  1 
ATOM   3270 H  H    . ILE A 1 252 ? 18.17000 12.64300  13.62400 1.000 27.76109  ? 252 ILE A H    1 
ATOM   3271 H  HA   . ILE A 1 252 ? 20.12800 11.08400  14.38300 1.000 26.80347  ? 252 ILE A HA   1 
ATOM   3272 H  HB   . ILE A 1 252 ? 17.37400 10.93900  15.05300 1.000 23.25338  ? 252 ILE A HB   1 
ATOM   3273 H  HG12 . ILE A 1 252 ? 19.47500 11.95700  16.63300 1.000 28.38909  ? 252 ILE A HG12 1 
ATOM   3274 H  HG13 . ILE A 1 252 ? 18.48800 12.88100  15.79800 1.000 28.38909  ? 252 ILE A HG13 1 
ATOM   3275 H  HG21 . ILE A 1 252 ? 18.15200 9.54900   16.88100 1.000 31.01350  ? 252 ILE A HG21 1 
ATOM   3276 H  HG22 . ILE A 1 252 ? 18.05300 8.84700   15.46000 1.000 31.01350  ? 252 ILE A HG22 1 
ATOM   3277 H  HG23 . ILE A 1 252 ? 19.46300 9.32900   16.01100 1.000 31.01350  ? 252 ILE A HG23 1 
ATOM   3278 H  HD11 . ILE A 1 252 ? 17.75700 12.95400  17.93300 1.000 34.48819  ? 252 ILE A HD11 1 
ATOM   3279 H  HD12 . ILE A 1 252 ? 16.71600 12.04300  17.15200 1.000 34.48819  ? 252 ILE A HD12 1 
ATOM   3280 H  HD13 . ILE A 1 252 ? 17.82600 11.37300  18.07100 1.000 34.48819  ? 252 ILE A HD13 1 
ATOM   3281 N  N    . MET A 1 253 ? 17.95300 9.66900   12.48900 1.000 26.23326  ? 253 MET A N    1 
ATOM   3282 C  CA   . MET A 1 253 ? 17.76500 8.59000   11.52300 1.000 26.72796  ? 253 MET A CA   1 
ATOM   3283 C  C    . MET A 1 253 ? 18.95600 8.47600   10.58200 1.000 27.74832  ? 253 MET A C    1 
ATOM   3284 O  O    . MET A 1 253 ? 19.57400 7.41400   10.45300 1.000 28.70720  ? 253 MET A O    1 
ATOM   3285 C  CB   . MET A 1 253 ? 16.49400 8.83100   10.70700 1.000 34.65572  ? 253 MET A CB   1 
ATOM   3286 C  CG   . MET A 1 253 ? 16.20000 7.72200   9.70400  1.000 31.07265  ? 253 MET A CG   1 
ATOM   3287 S  SD   . MET A 1 253 ? 14.44900 7.45100   9.37200  1.000 31.31285  ? 253 MET A SD   1 
ATOM   3288 C  CE   . MET A 1 253 ? 14.54200 6.04600   8.26100  1.000 36.88664  ? 253 MET A CE   1 
ATOM   3289 H  H    . MET A 1 253 ? 17.27300 10.18900  12.56900 1.000 31.41967  ? 253 MET A H    1 
ATOM   3290 H  HA   . MET A 1 253 ? 17.66300 7.76300   12.02000 1.000 32.01331  ? 253 MET A HA   1 
ATOM   3291 H  HB2  . MET A 1 253 ? 15.73900 8.89300   11.31300 1.000 41.52662  ? 253 MET A HB2  1 
ATOM   3292 H  HB3  . MET A 1 253 ? 16.59100 9.66100   10.21300 1.000 41.52662  ? 253 MET A HB3  1 
ATOM   3293 H  HG2  . MET A 1 253 ? 16.62500 7.94600   8.86100  1.000 37.22695  ? 253 MET A HG2  1 
ATOM   3294 H  HG3  . MET A 1 253 ? 16.56300 6.89100   10.04800 1.000 37.22695  ? 253 MET A HG3  1 
ATOM   3295 H  HE1  . MET A 1 253 ? 13.64300 5.78900   8.00200  1.000 44.20373  ? 253 MET A HE1  1 
ATOM   3296 H  HE2  . MET A 1 253 ? 15.05300 6.29700   7.47600  1.000 44.20373  ? 253 MET A HE2  1 
ATOM   3297 H  HE3  . MET A 1 253 ? 14.97800 5.31000   8.71800  1.000 44.20373  ? 253 MET A HE3  1 
ATOM   3298 N  N    . GLY A 1 254 ? 19.27300 9.57000   9.88700  1.000 24.78317  ? 254 GLY A N    1 
ATOM   3299 C  CA   . GLY A 1 254 ? 20.33200 9.52700   8.89500  1.000 26.07801  ? 254 GLY A CA   1 
ATOM   3300 C  C    . GLY A 1 254 ? 21.68100 9.17300   9.48000  1.000 31.70616  ? 254 GLY A C    1 
ATOM   3301 O  O    . GLY A 1 254 ? 22.49700 8.52100   8.81900  1.000 25.14739  ? 254 GLY A O    1 
ATOM   3302 H  H    . GLY A 1 254 ? 18.89300 10.33700  9.97400  1.000 29.67956  ? 254 GLY A H    1 
ATOM   3303 H  HA2  . GLY A 1 254 ? 20.11000 8.86400   8.22200  1.000 31.23337  ? 254 GLY A HA2  1 
ATOM   3304 H  HA3  . GLY A 1 254 ? 20.40500 10.39600  8.47000  1.000 31.23337  ? 254 GLY A HA3  1 
ATOM   3305 N  N    . GLU A 1 255 ? 21.94000 9.59600   10.72000 1.000 25.74908  ? 255 GLU A N    1 
ATOM   3306 C  CA   . GLU A 1 255 ? 23.20200 9.25300   11.36200 1.000 29.71980  ? 255 GLU A CA   1 
ATOM   3307 C  C    . GLU A 1 255 ? 23.25700 7.77300   11.73100 1.000 30.67030  ? 255 GLU A C    1 
ATOM   3308 O  O    . GLU A 1 255 ? 24.34300 7.18400   11.74700 1.000 31.14544  ? 255 GLU A O    1 
ATOM   3309 C  CB   . GLU A 1 255 ? 23.41300 10.12600  12.59900 1.000 31.97745  ? 255 GLU A CB   1 
ATOM   3310 C  CG   . GLU A 1 255 ? 24.73700 9.88900   13.29700 1.000 31.71644  ? 255 GLU A CG   1 
ATOM   3311 C  CD   . GLU A 1 255 ? 25.06600 10.96000  14.31700 1.000 40.92313  ? 255 GLU A CD   1 
ATOM   3312 O  OE1  . GLU A 1 255 ? 24.30900 11.95100  14.41400 1.000 35.11146  ? 255 GLU A OE1  1 
ATOM   3313 O  OE2  . GLU A 1 255 ? 26.07500 10.80100  15.03800 1.000 37.62423  ? 255 GLU A OE2  1 
ATOM   3314 H  H    . GLU A 1 255 ? 21.41000 10.07400  11.20000 1.000 30.83866  ? 255 GLU A H    1 
ATOM   3315 H  HA   . GLU A 1 255 ? 23.92900 9.43100   10.74600 1.000 35.60352  ? 255 GLU A HA   1 
ATOM   3316 H  HB2  . GLU A 1 255 ? 23.38200 11.05800  12.33200 1.000 38.31270  ? 255 GLU A HB2  1 
ATOM   3317 H  HB3  . GLU A 1 255 ? 22.70500 9.94000   13.23600 1.000 38.31270  ? 255 GLU A HB3  1 
ATOM   3318 H  HG2  . GLU A 1 255 ? 24.70200 9.03600   13.75800 1.000 37.99949  ? 255 GLU A HG2  1 
ATOM   3319 H  HG3  . GLU A 1 255 ? 25.44500 9.87900   12.63400 1.000 37.99949  ? 255 GLU A HG3  1 
ATOM   3320 N  N    . MET A 1 256 ? 22.10900 7.15600   12.03400 1.000 28.44106  ? 256 MET A N    1 
ATOM   3321 C  CA   . MET A 1 256 ? 22.09500 5.71200   12.25400 1.000 28.49812  ? 256 MET A CA   1 
ATOM   3322 C  C    . MET A 1 256 ? 22.51400 4.96900   10.99200 1.000 35.12219  ? 256 MET A C    1 
ATOM   3323 O  O    . MET A 1 256 ? 23.16600 3.92100   11.06500 1.000 39.69156  ? 256 MET A O    1 
ATOM   3324 C  CB   . MET A 1 256 ? 20.70600 5.23700   12.68700 1.000 31.01651  ? 256 MET A CB   1 
ATOM   3325 C  CG   . MET A 1 256 ? 20.12400 5.91000   13.91400 1.000 29.24918  ? 256 MET A CG   1 
ATOM   3326 S  SD   . MET A 1 256 ? 18.76500 4.94900   14.60200 1.000 52.67288  ? 256 MET A SD   1 
ATOM   3327 C  CE   . MET A 1 256 ? 17.34900 5.61800   13.75200 1.000 39.39755  ? 256 MET A CE   1 
ATOM   3328 H  H    . MET A 1 256 ? 21.34500 7.54300   12.11600 1.000 34.06903  ? 256 MET A H    1 
ATOM   3329 H  HA   . MET A 1 256 ? 22.71300 5.51700   12.97500 1.000 34.13751  ? 256 MET A HA   1 
ATOM   3330 H  HB2  . MET A 1 256 ? 20.09000 5.39500   11.95400 1.000 37.15958  ? 256 MET A HB2  1 
ATOM   3331 H  HB3  . MET A 1 256 ? 20.75700 4.28700   12.87800 1.000 37.15958  ? 256 MET A HB3  1 
ATOM   3332 H  HG2  . MET A 1 256 ? 20.81300 5.99600   14.59100 1.000 35.03878  ? 256 MET A HG2  1 
ATOM   3333 H  HG3  . MET A 1 256 ? 19.78800 6.78700   13.67100 1.000 35.03878  ? 256 MET A HG3  1 
ATOM   3334 H  HE1  . MET A 1 256 ? 16.57300 5.07300   13.95600 1.000 47.21682  ? 256 MET A HE1  1 
ATOM   3335 H  HE2  . MET A 1 256 ? 17.20300 6.52900   14.05100 1.000 47.21682  ? 256 MET A HE2  1 
ATOM   3336 H  HE3  . MET A 1 256 ? 17.52000 5.60700   12.79700 1.000 47.21682  ? 256 MET A HE3  1 
ATOM   3337 N  N    . VAL A 1 257 ? 22.13100 5.49100   9.82700  1.000 32.39970  ? 257 VAL A N    1 
ATOM   3338 C  CA   . VAL A 1 257 ? 22.44500 4.83600   8.56100  1.000 39.89915  ? 257 VAL A CA   1 
ATOM   3339 C  C    . VAL A 1 257 ? 23.88000 5.13000   8.14600  1.000 38.57335  ? 257 VAL A C    1 
ATOM   3340 O  O    . VAL A 1 257 ? 24.63400 4.22700   7.76500  1.000 36.28553  ? 257 VAL A O    1 
ATOM   3341 C  CB   . VAL A 1 257 ? 21.45400 5.29000   7.47100  1.000 26.63695  ? 257 VAL A CB   1 
ATOM   3342 C  CG1  . VAL A 1 257 ? 21.64700 4.47300   6.20700  1.000 45.65085  ? 257 VAL A CG1  1 
ATOM   3343 C  CG2  . VAL A 1 257 ? 20.01900 5.19300   7.96300  1.000 30.55336  ? 257 VAL A CG2  1 
ATOM   3344 H  H    . VAL A 1 257 ? 21.68900 6.22300   9.74300  1.000 38.81940  ? 257 VAL A H    1 
ATOM   3345 H  HA   . VAL A 1 257 ? 22.35400 3.87800   8.68000  1.000 47.81875  ? 257 VAL A HA   1 
ATOM   3346 H  HB   . VAL A 1 257 ? 21.63000 6.22100   7.26200  1.000 31.90410  ? 257 VAL A HB   1 
ATOM   3347 H  HG11 . VAL A 1 257 ? 20.96500 4.72100   5.56300  1.000 54.72078  ? 257 VAL A HG11 1 
ATOM   3348 H  HG12 . VAL A 1 257 ? 22.52700 4.65600   5.84300  1.000 54.72078  ? 257 VAL A HG12 1 
ATOM   3349 H  HG13 . VAL A 1 257 ? 21.56900 3.53100   6.42500  1.000 54.72078  ? 257 VAL A HG13 1 
ATOM   3350 H  HG21 . VAL A 1 257 ? 19.41900 5.40400   7.23100  1.000 36.60380  ? 257 VAL A HG21 1 
ATOM   3351 H  HG22 . VAL A 1 257 ? 19.85300 4.28900   8.27600  1.000 36.60380  ? 257 VAL A HG22 1 
ATOM   3352 H  HG23 . VAL A 1 257 ? 19.89100 5.82300   8.68900  1.000 36.60380  ? 257 VAL A HG23 1 
ATOM   3353 N  N    . ARG A 1 258 ? 24.27400 6.39900   8.21400  1.000 30.01782  ? 258 ARG A N    1 
ATOM   3354 C  CA   . ARG A 1 258 ? 25.56300 6.84600   7.71200  1.000 26.09400  ? 258 ARG A CA   1 
ATOM   3355 C  C    . ARG A 1 258 ? 26.68500 6.69400   8.72800  1.000 36.08114  ? 258 ARG A C    1 
ATOM   3356 O  O    . ARG A 1 258 ? 27.85600 6.64100   8.33300  1.000 39.72695  ? 258 ARG A O    1 
ATOM   3357 C  CB   . ARG A 1 258 ? 25.45800 8.31600   7.28400  1.000 33.96450  ? 258 ARG A CB   1 
ATOM   3358 C  CG   . ARG A 1 258 ? 26.65100 8.83800   6.50500  1.000 44.78297  ? 258 ARG A CG   1 
ATOM   3359 C  CD   . ARG A 1 258 ? 26.49000 10.31100  6.15500  1.000 46.53894  ? 258 ARG A CD   1 
ATOM   3360 N  NE   . ARG A 1 258 ? 25.58600 10.55200  5.03300  1.000 43.57231  ? 258 ARG A NE   1 
ATOM   3361 C  CZ   . ARG A 1 258 ? 25.24000 11.76100  4.60600  1.000 45.13758  ? 258 ARG A CZ   1 
ATOM   3362 N  NH1  . ARG A 1 258 ? 25.71700 12.85500  5.17500  1.000 38.42131  ? 258 ARG A NH1  1 
ATOM   3363 N  NH2  . ARG A 1 258 ? 24.39700 11.87400  3.58400  1.000 42.90965  ? 258 ARG A NH2  1 
ATOM   3364 H  H    . ARG A 1 258 ? 23.80000 7.03100   8.55400  1.000 35.96114  ? 258 ARG A H    1 
ATOM   3365 H  HA   . ARG A 1 258 ? 25.80500 6.31800   6.93600  1.000 31.25256  ? 258 ARG A HA   1 
ATOM   3366 H  HB2  . ARG A 1 258 ? 24.67500 8.41700   6.72000  1.000 40.69716  ? 258 ARG A HB2  1 
ATOM   3367 H  HB3  . ARG A 1 258 ? 25.36700 8.86300   8.08000  1.000 40.69716  ? 258 ARG A HB3  1 
ATOM   3368 H  HG2  . ARG A 1 258 ? 27.45300 8.73900   7.04100  1.000 53.67933  ? 258 ARG A HG2  1 
ATOM   3369 H  HG3  . ARG A 1 258 ? 26.73900 8.33700   5.67900  1.000 53.67933  ? 258 ARG A HG3  1 
ATOM   3370 H  HD2  . ARG A 1 258 ? 26.13500 10.77900  6.92600  1.000 55.78649  ? 258 ARG A HD2  1 
ATOM   3371 H  HD3  . ARG A 1 258 ? 27.35800 10.67200  5.91800  1.000 55.78649  ? 258 ARG A HD3  1 
ATOM   3372 H  HE   . ARG A 1 258 ? 25.25800 9.87000   4.62500  1.000 52.22653  ? 258 ARG A HE   1 
ATOM   3373 H  HH11 . ARG A 1 258 ? 26.26400 12.79400  5.83600  1.000 46.04533  ? 258 ARG A HH11 1 
ATOM   3374 H  HH12 . ARG A 1 258 ? 25.48100 13.62900  4.88400  1.000 46.04533  ? 258 ARG A HH12 1 
ATOM   3375 H  HH21 . ARG A 1 258 ? 24.08100 11.16800  3.20700  1.000 51.43134  ? 258 ARG A HH21 1 
ATOM   3376 H  HH22 . ARG A 1 258 ? 24.16700 12.65200  3.30000  1.000 51.43134  ? 258 ARG A HH22 1 
ATOM   3377 N  N    . HIS A 1 259 ? 26.35500 6.61700   10.01900 1.000 35.21131  ? 259 HIS A N    1 
ATOM   3378 C  CA   . HIS A 1 259 ? 27.34500 6.58200   11.09900 1.000 41.95435  ? 259 HIS A CA   1 
ATOM   3379 C  C    . HIS A 1 259 ? 28.27800 7.78600   11.04000 1.000 42.20369  ? 259 HIS A C    1 
ATOM   3380 O  O    . HIS A 1 259 ? 29.45700 7.69600   11.39600 1.000 36.89318  ? 259 HIS A O    1 
ATOM   3381 C  CB   . HIS A 1 259 ? 28.14100 5.27700   11.08200 1.000 42.05264  ? 259 HIS A CB   1 
ATOM   3382 C  CG   . HIS A 1 259 ? 27.28700 4.06000   11.24300 1.000 34.47972  ? 259 HIS A CG   1 
ATOM   3383 N  ND1  . HIS A 1 259 ? 26.58500 3.79500   12.39800 1.000 27.34420  ? 259 HIS A ND1  1 
ATOM   3384 C  CD2  . HIS A 1 259 ? 27.00900 3.04500   10.39100 1.000 30.20809  ? 259 HIS A CD2  1 
ATOM   3385 C  CE1  . HIS A 1 259 ? 25.91500 2.66600   12.25400 1.000 30.40740  ? 259 HIS A CE1  1 
ATOM   3386 N  NE2  . HIS A 1 259 ? 26.15500 2.19100   11.04400 1.000 24.82985  ? 259 HIS A NE2  1 
ATOM   3387 H  H    . HIS A 1 259 ? 25.54400 6.58300   10.30300 1.000 42.19334  ? 259 HIS A H    1 
ATOM   3388 H  HA   . HIS A 1 259 ? 26.87400 6.62500   11.94600 1.000 50.28498  ? 259 HIS A HA   1 
ATOM   3389 H  HB2  . HIS A 1 259 ? 28.60500 5.20400   10.23300 1.000 50.40293  ? 259 HIS A HB2  1 
ATOM   3390 H  HB3  . HIS A 1 259 ? 28.78100 5.29000   11.81000 1.000 50.40293  ? 259 HIS A HB3  1 
ATOM   3391 H  HD1  . HIS A 1 259 ? 26.58300 4.28700   13.10300 1.000 32.75280  ? 259 HIS A HD1  1 
ATOM   3392 H  HD2  . HIS A 1 259 ? 27.33500 2.94500   9.52600  1.000 36.18947  ? 259 HIS A HD2  1 
ATOM   3393 H  HE1  . HIS A 1 259 ? 25.36700 2.27300   12.89400 1.000 36.42864  ? 259 HIS A HE1  1 
ATOM   3394 N  N    . LYS A 1 260 ? 27.74200 8.91400   10.58300 1.000 35.01265  ? 260 LYS A N    1 
ATOM   3395 C  CA   . LYS A 1 260 ? 28.42900 10.19500  10.60600 1.000 39.85442  ? 260 LYS A CA   1 
ATOM   3396 C  C    . LYS A 1 260 ? 27.38000 11.27200  10.83500 1.000 30.87722  ? 260 LYS A C    1 
ATOM   3397 O  O    . LYS A 1 260 ? 26.24900 11.15200  10.36000 1.000 29.95898  ? 260 LYS A O    1 
ATOM   3398 C  CB   . LYS A 1 260 ? 29.18400 10.46900  9.30000  1.000 52.09527  ? 260 LYS A CB   1 
ATOM   3399 C  CG   . LYS A 1 260 ? 30.64800 10.04300  9.30000  1.000 64.29187  ? 260 LYS A CG   1 
ATOM   3400 C  CD   . LYS A 1 260 ? 31.47100 10.86200  10.28900 1.000 76.28020  ? 260 LYS A CD   1 
ATOM   3401 C  CE   . LYS A 1 260 ? 32.92400 10.97300  9.84900  1.000 71.01711  ? 260 LYS A CE   1 
ATOM   3402 N  NZ   . LYS A 1 260 ? 33.84100 11.26300  10.98700 1.000 64.76518  ? 260 LYS A NZ   1 
ATOM   3403 H  H    . LYS A 1 260 ? 26.95300 8.96200   10.24200 1.000 41.95495  ? 260 LYS A H    1 
ATOM   3404 H  HA   . LYS A 1 260 ? 29.07800 10.21000  11.32700 1.000 47.76507  ? 260 LYS A HA   1 
ATOM   3405 H  HB2  . LYS A 1 260 ? 28.74100 9.98900   8.58300  1.000 62.45408  ? 260 LYS A HB2  1 
ATOM   3406 H  HB3  . LYS A 1 260 ? 29.15900 11.42300  9.12600  1.000 62.45408  ? 260 LYS A HB3  1 
ATOM   3407 H  HG2  . LYS A 1 260 ? 30.71000 9.10800   9.55300  1.000 77.09000  ? 260 LYS A HG2  1 
ATOM   3408 H  HG3  . LYS A 1 260 ? 31.02000 10.17200  8.41400  1.000 77.09000  ? 260 LYS A HG3  1 
ATOM   3409 H  HD2  . LYS A 1 260 ? 31.10200 11.75700  10.35000 1.000 91.47601  ? 260 LYS A HD2  1 
ATOM   3410 H  HD3  . LYS A 1 260 ? 31.44800 10.43400  11.15900 1.000 91.47601  ? 260 LYS A HD3  1 
ATOM   3411 H  HE2  . LYS A 1 260 ? 33.19900 10.13400  9.44700  1.000 85.16029  ? 260 LYS A HE2  1 
ATOM   3412 H  HE3  . LYS A 1 260 ? 33.00700 11.69300  9.20500  1.000 85.16029  ? 260 LYS A HE3  1 
ATOM   3413 H  HZ1  . LYS A 1 260 ? 34.67800 11.33000  10.69400 1.000 77.65797  ? 260 LYS A HZ1  1 
ATOM   3414 H  HZ2  . LYS A 1 260 ? 33.60900 12.02800  11.37700 1.000 77.65797  ? 260 LYS A HZ2  1 
ATOM   3415 H  HZ3  . LYS A 1 260 ? 33.79700 10.60700  11.58800 1.000 77.65797  ? 260 LYS A HZ3  1 
ATOM   3416 N  N    . ILE A 1 261 ? 27.75500 12.31100  11.58000 1.000 33.19765  ? 261 ILE A N    1 
ATOM   3417 C  CA   . ILE A 1 261 ? 26.87400 13.45900  11.73900 1.000 26.07263  ? 261 ILE A CA   1 
ATOM   3418 C  C    . ILE A 1 261 ? 26.57900 14.03700  10.36300 1.000 29.36304  ? 261 ILE A C    1 
ATOM   3419 O  O    . ILE A 1 261 ? 27.49000 14.25800  9.55500  1.000 30.02118  ? 261 ILE A O    1 
ATOM   3420 C  CB   . ILE A 1 261 ? 27.51800 14.49300  12.67300 1.000 28.66675  ? 261 ILE A CB   1 
ATOM   3421 C  CG1  . ILE A 1 261 ? 27.64400 13.91500  14.08600 1.000 37.32018  ? 261 ILE A CG1  1 
ATOM   3422 C  CG2  . ILE A 1 261 ? 26.70500 15.77500  12.68900 1.000 30.92209  ? 261 ILE A CG2  1 
ATOM   3423 C  CD1  . ILE A 1 261 ? 28.66900 14.61500  14.94300 1.000 40.47723  ? 261 ILE A CD1  1 
ATOM   3424 H  H    . ILE A 1 261 ? 28.50500 12.37200  11.99800 1.000 39.77695  ? 261 ILE A H    1 
ATOM   3425 H  HA   . ILE A 1 261 ? 26.03700 13.18000  12.14100 1.000 31.22691  ? 261 ILE A HA   1 
ATOM   3426 H  HB   . ILE A 1 261 ? 28.40500 14.70100  12.34200 1.000 34.33986  ? 261 ILE A HB   1 
ATOM   3427 H  HG12 . ILE A 1 261 ? 26.78500 13.99000  14.53200 1.000 44.72397  ? 261 ILE A HG12 1 
ATOM   3428 H  HG13 . ILE A 1 261 ? 27.90300 12.98300  14.01900 1.000 44.72397  ? 261 ILE A HG13 1 
ATOM   3429 H  HG21 . ILE A 1 261 ? 26.96300 16.30200  13.46200 1.000 37.04626  ? 261 ILE A HG21 1 
ATOM   3430 H  HG22 . ILE A 1 261 ? 26.88300 16.27100  11.87500 1.000 37.04626  ? 261 ILE A HG22 1 
ATOM   3431 H  HG23 . ILE A 1 261 ? 25.76300 15.55000  12.74100 1.000 37.04626  ? 261 ILE A HG23 1 
ATOM   3432 H  HD11 . ILE A 1 261 ? 28.77200 14.12700  15.77500 1.000 48.51244  ? 261 ILE A HD11 1 
ATOM   3433 H  HD12 . ILE A 1 261 ? 29.51400 14.64100  14.46800 1.000 48.51244  ? 261 ILE A HD12 1 
ATOM   3434 H  HD13 . ILE A 1 261 ? 28.36400 15.51800  15.12600 1.000 48.51244  ? 261 ILE A HD13 1 
ATOM   3435 N  N    . LEU A 1 262 ? 25.29400 14.27100  10.08100 1.000 27.53874  ? 262 LEU A N    1 
ATOM   3436 C  CA   . LEU A 1 262 ? 24.91000 14.72100  8.74600  1.000 27.37748  ? 262 LEU A CA   1 
ATOM   3437 C  C    . LEU A 1 262 ? 25.36300 16.15000  8.48100  1.000 31.13909  ? 262 LEU A C    1 
ATOM   3438 O  O    . LEU A 1 262 ? 25.85100 16.46100  7.38800  1.000 29.38524  ? 262 LEU A O    1 
ATOM   3439 C  CB   . LEU A 1 262 ? 23.39500 14.61900  8.56200  1.000 25.49508  ? 262 LEU A CB   1 
ATOM   3440 C  CG   . LEU A 1 262 ? 22.73300 13.25000  8.72200  1.000 32.72678  ? 262 LEU A CG   1 
ATOM   3441 C  CD1  . LEU A 1 262 ? 21.29200 13.32600  8.24300  1.000 26.56674  ? 262 LEU A CD1  1 
ATOM   3442 C  CD2  . LEU A 1 262 ? 23.49600 12.17800  7.97000  1.000 33.97846  ? 262 LEU A CD2  1 
ATOM   3443 H  H    . LEU A 1 262 ? 24.64100 14.17900  10.63300 1.000 32.98625  ? 262 LEU A H    1 
ATOM   3444 H  HA   . LEU A 1 262 ? 25.33800 14.13700  8.10000  1.000 32.79274  ? 262 LEU A HA   1 
ATOM   3445 H  HB2  . LEU A 1 262 ? 22.98100 15.20400  9.21600  1.000 30.53386  ? 262 LEU A HB2  1 
ATOM   3446 H  HB3  . LEU A 1 262 ? 23.18700 14.92400  7.66500  1.000 30.53386  ? 262 LEU A HB3  1 
ATOM   3447 H  HG   . LEU A 1 262 ? 22.74100 12.99600  9.65800  1.000 39.21190  ? 262 LEU A HG   1 
ATOM   3448 H  HD11 . LEU A 1 262 ? 20.79700 12.57800  8.61100  1.000 31.81985  ? 262 LEU A HD11 1 
ATOM   3449 H  HD12 . LEU A 1 262 ? 20.90300 14.16100  8.54700  1.000 31.81985  ? 262 LEU A HD12 1 
ATOM   3450 H  HD13 . LEU A 1 262 ? 21.27900 13.28800  7.27400  1.000 31.81985  ? 262 LEU A HD13 1 
ATOM   3451 H  HD21 . LEU A 1 262 ? 22.98200 11.35600  7.98500  1.000 40.71391  ? 262 LEU A HD21 1 
ATOM   3452 H  HD22 . LEU A 1 262 ? 23.62900 12.46900  7.05400  1.000 40.71391  ? 262 LEU A HD22 1 
ATOM   3453 H  HD23 . LEU A 1 262 ? 24.35400 12.04000  8.40100  1.000 40.71391  ? 262 LEU A HD23 1 
ATOM   3454 N  N    . PHE A 1 263 ? 25.19800 17.03700  9.45700  1.000 28.24086  ? 263 PHE A N    1 
ATOM   3455 C  CA   . PHE A 1 263 ? 25.40700 18.47200  9.26500  1.000 24.69052  ? 263 PHE A CA   1 
ATOM   3456 C  C    . PHE A 1 263 ? 26.32400 19.00100  10.35800 1.000 26.62935  ? 263 PHE A C    1 
ATOM   3457 O  O    . PHE A 1 263 ? 25.89900 19.75200  11.24200 1.000 30.00749  ? 263 PHE A O    1 
ATOM   3458 C  CB   . PHE A 1 263 ? 24.06200 19.19900  9.24600  1.000 26.68474  ? 263 PHE A CB   1 
ATOM   3459 C  CG   . PHE A 1 263 ? 23.06100 18.56900  8.31500  1.000 24.51357  ? 263 PHE A CG   1 
ATOM   3460 C  CD1  . PHE A 1 263 ? 23.32500 18.48000  6.96100  1.000 26.89768  ? 263 PHE A CD1  1 
ATOM   3461 C  CD2  . PHE A 1 263 ? 21.87100 18.04900  8.79400  1.000 28.45282  ? 263 PHE A CD2  1 
ATOM   3462 C  CE1  . PHE A 1 263 ? 22.41700 17.89200  6.09800  1.000 29.61535  ? 263 PHE A CE1  1 
ATOM   3463 C  CE2  . PHE A 1 263 ? 20.95800 17.46100  7.93700  1.000 24.99650  ? 263 PHE A CE2  1 
ATOM   3464 C  CZ   . PHE A 1 263 ? 21.23300 17.38200  6.58800  1.000 22.00761  ? 263 PHE A CZ   1 
ATOM   3465 H  H    . PHE A 1 263 ? 24.96000 16.82900  10.25700 1.000 33.82879  ? 263 PHE A H    1 
ATOM   3466 H  HA   . PHE A 1 263 ? 25.85400 18.63000  8.41800  1.000 29.56838  ? 263 PHE A HA   1 
ATOM   3467 H  HB2  . PHE A 1 263 ? 23.68600 19.18700  10.14000 1.000 31.96145  ? 263 PHE A HB2  1 
ATOM   3468 H  HB3  . PHE A 1 263 ? 24.20300 20.11400  8.95700  1.000 31.96145  ? 263 PHE A HB3  1 
ATOM   3469 H  HD1  . PHE A 1 263 ? 24.12400 18.82000  6.62500  1.000 32.21697  ? 263 PHE A HD1  1 
ATOM   3470 H  HD2  . PHE A 1 263 ? 21.68300 18.09600  9.70400  1.000 34.08315  ? 263 PHE A HD2  1 
ATOM   3471 H  HE1  . PHE A 1 263 ? 22.60400 17.84100  5.18900  1.000 35.47819  ? 263 PHE A HE1  1 
ATOM   3472 H  HE2  . PHE A 1 263 ? 20.16000 17.12000  8.27100  1.000 29.93556  ? 263 PHE A HE2  1 
ATOM   3473 H  HZ   . PHE A 1 263 ? 20.62200 16.98500  6.01000  1.000 26.34889  ? 263 PHE A HZ   1 
ATOM   3474 N  N    . PRO A 1 264 ? 27.60400 18.61700  10.32500 1.000 28.83921  ? 264 PRO A N    1 
ATOM   3475 C  CA   . PRO A 1 264 ? 28.56400 19.13700  11.30800 1.000 30.09370  ? 264 PRO A CA   1 
ATOM   3476 C  C    . PRO A 1 264 ? 28.92900 20.58800  11.04900 1.000 31.89305  ? 264 PRO A C    1 
ATOM   3477 O  O    . PRO A 1 264 ? 28.50500 21.16900  10.04300 1.000 27.65073  ? 264 PRO A O    1 
ATOM   3478 C  CB   . PRO A 1 264 ? 29.78000 18.21900  11.12500 1.000 29.39383  ? 264 PRO A CB   1 
ATOM   3479 C  CG   . PRO A 1 264 ? 29.68700 17.77000  9.70300  1.000 35.66792  ? 264 PRO A CG   1 
ATOM   3480 C  CD   . PRO A 1 264 ? 28.21800 17.63200  9.41600  1.000 35.16874  ? 264 PRO A CD   1 
ATOM   3481 H  HA   . PRO A 1 264 ? 28.21400 19.04300  12.20700 1.000 36.05220  ? 264 PRO A HA   1 
ATOM   3482 H  HB2  . PRO A 1 264 ? 30.59900 18.71400  11.28300 1.000 35.21235  ? 264 PRO A HB2  1 
ATOM   3483 H  HB3  . PRO A 1 264 ? 29.72500 17.46600  11.73400 1.000 35.21235  ? 264 PRO A HB3  1 
ATOM   3484 H  HG2  . PRO A 1 264 ? 30.09000 18.43400  9.12200  1.000 42.74126  ? 264 PRO A HG2  1 
ATOM   3485 H  HG3  . PRO A 1 264 ? 30.14000 16.91900  9.59700  1.000 42.74126  ? 264 PRO A HG3  1 
ATOM   3486 H  HD2  . PRO A 1 264 ? 28.02500 17.84800  8.49000  1.000 42.14225  ? 264 PRO A HD2  1 
ATOM   3487 H  HD3  . PRO A 1 264 ? 27.90900 16.73500  9.61800  1.000 42.14225  ? 264 PRO A HD3  1 
ATOM   3488 N  N    . GLY A 1 265 ? 29.72200 21.17900  11.93900 1.000 32.28702  ? 265 GLY A N    1 
ATOM   3489 C  CA   . GLY A 1 265 ? 30.22100 22.52200  11.71400 1.000 36.38370  ? 265 GLY A CA   1 
ATOM   3490 C  C    . GLY A 1 265 ? 30.63400 23.24400  12.97800 1.000 36.89223  ? 265 GLY A C    1 
ATOM   3491 O  O    . GLY A 1 265 ? 30.08500 22.99300  14.05400 1.000 35.04044  ? 265 GLY A O    1 
ATOM   3492 H  H    . GLY A 1 265 ? 29.98300 20.82100  12.67600 1.000 38.68418  ? 265 GLY A H    1 
ATOM   3493 H  HA2  . GLY A 1 265 ? 30.99300 22.47800  11.12900 1.000 43.60020  ? 265 GLY A HA2  1 
ATOM   3494 H  HA3  . GLY A 1 265 ? 29.52800 23.04700  11.28300 1.000 43.60020  ? 265 GLY A HA3  1 
ATOM   3495 N  N    . ARG A 1 266 ? 31.61100 24.14600  12.85400 1.000 36.14058  ? 266 ARG A N    1 
ATOM   3496 C  CA   . ARG A 1 266 ? 32.02100 24.95600  13.99500 1.000 37.85824  ? 266 ARG A CA   1 
ATOM   3497 C  C    . ARG A 1 266 ? 30.85300 25.77000  14.53200 1.000 38.10718  ? 266 ARG A C    1 
ATOM   3498 O  O    . ARG A 1 266 ? 30.65600 25.86700  15.74900 1.000 33.83942  ? 266 ARG A O    1 
ATOM   3499 C  CB   . ARG A 1 266 ? 33.16900 25.88500  13.59300 1.000 43.01549  ? 266 ARG A CB   1 
ATOM   3500 C  CG   . ARG A 1 266 ? 34.47300 25.17000  13.26900 1.000 48.46576  ? 266 ARG A CG   1 
ATOM   3501 C  CD   . ARG A 1 266 ? 35.48400 26.10700  12.61500 1.000 46.66423  ? 266 ARG A CD   1 
ATOM   3502 N  NE   . ARG A 1 266 ? 35.10500 26.48800  11.25800 1.000 48.23599  ? 266 ARG A NE   1 
ATOM   3503 C  CZ   . ARG A 1 266 ? 35.73400 27.40700  10.53400 1.000 52.77128  ? 266 ARG A CZ   1 
ATOM   3504 N  NH1  . ARG A 1 266 ? 36.79800 28.04200  10.99700 1.000 35.98389  ? 266 ARG A NH1  1 
ATOM   3505 N  NH2  . ARG A 1 266 ? 35.28700 27.69100  9.31300  1.000 40.47020  ? 266 ARG A NH2  1 
ATOM   3506 H  H    . ARG A 1 266 ? 32.04500 24.30500  12.12900 1.000 43.30846  ? 266 ARG A H    1 
ATOM   3507 H  HA   . ARG A 1 266 ? 32.33800 24.36800  14.69900 1.000 45.36965  ? 266 ARG A HA   1 
ATOM   3508 H  HB2  . ARG A 1 266 ? 32.90300 26.38200  12.80300 1.000 51.55835  ? 266 ARG A HB2  1 
ATOM   3509 H  HB3  . ARG A 1 266 ? 33.34400 26.49600  14.32600 1.000 51.55835  ? 266 ARG A HB3  1 
ATOM   3510 H  HG2  . ARG A 1 266 ? 34.86200 24.82800  14.08900 1.000 58.09868  ? 266 ARG A HG2  1 
ATOM   3511 H  HG3  . ARG A 1 266 ? 34.29400 24.44000  12.65600 1.000 58.09868  ? 266 ARG A HG3  1 
ATOM   3512 H  HD2  . ARG A 1 266 ? 35.55500 26.91600  13.14500 1.000 55.93684  ? 266 ARG A HD2  1 
ATOM   3513 H  HD3  . ARG A 1 266 ? 36.34500 25.66200  12.57200 1.000 55.93684  ? 266 ARG A HD3  1 
ATOM   3514 H  HE   . ARG A 1 266 ? 34.42900 26.09200  10.90400 1.000 57.82295  ? 266 ARG A HE   1 
ATOM   3515 H  HH11 . ARG A 1 266 ? 37.09800 27.86300  11.78300 1.000 43.12043  ? 266 ARG A HH11 1 
ATOM   3516 H  HH12 . ARG A 1 266 ? 37.19000 28.63400  10.51100 1.000 43.12043  ? 266 ARG A HH12 1 
ATOM   3517 H  HH21 . ARG A 1 266 ? 34.59900 27.28000  9.00000  1.000 48.50400  ? 266 ARG A HH21 1 
ATOM   3518 H  HH22 . ARG A 1 266 ? 35.68700 28.28400  8.83500  1.000 48.50400  ? 266 ARG A HH22 1 
ATOM   3519 N  N    . ASP A 1 267 ? 30.06600 26.35600  13.63300 1.000 32.96097  ? 267 ASP A N    1 
ATOM   3520 C  CA   . ASP A 1 267 ? 28.97500 27.24700  13.99100 1.000 35.49782  ? 267 ASP A CA   1 
ATOM   3521 C  C    . ASP A 1 267 ? 27.84400 27.04000  12.99300 1.000 29.47898  ? 267 ASP A C    1 
ATOM   3522 O  O    . ASP A 1 267 ? 27.93600 26.20900  12.08500 1.000 26.78836  ? 267 ASP A O    1 
ATOM   3523 C  CB   . ASP A 1 267 ? 29.44200 28.70800  13.99800 1.000 52.50826  ? 267 ASP A CB   1 
ATOM   3524 C  CG   . ASP A 1 267 ? 30.05400 29.13000  12.67300 1.000 43.01447  ? 267 ASP A CG   1 
ATOM   3525 O  OD1  . ASP A 1 267 ? 30.36100 28.24200  11.84200 1.000 48.19198  ? 267 ASP A OD1  1 
ATOM   3526 O  OD2  . ASP A 1 267 ? 30.22700 30.34800  12.45600 1.000 61.49374  ? 267 ASP A OD2  1 
ATOM   3527 H  H    . ASP A 1 267 ? 30.14800 26.24700  12.78400 1.000 39.49293  ? 267 ASP A H    1 
ATOM   3528 H  HA   . ASP A 1 267 ? 28.65600 27.01900  14.87900 1.000 42.53715  ? 267 ASP A HA   1 
ATOM   3529 H  HB2  . ASP A 1 267 ? 28.68100 29.28300  14.17400 1.000 62.94968  ? 267 ASP A HB2  1 
ATOM   3530 H  HB3  . ASP A 1 267 ? 30.11200 28.82300  14.68900 1.000 62.94968  ? 267 ASP A HB3  1 
ATOM   3531 N  N    . TYR A 1 268 ? 26.77100 27.81800  13.15800 1.000 26.62942  ? 268 TYR A N    1 
ATOM   3532 C  CA   . TYR A 1 268 ? 25.66500 27.74300  12.21000 1.000 32.43149  ? 268 TYR A CA   1 
ATOM   3533 C  C    . TYR A 1 268 ? 26.13100 28.01900  10.78400 1.000 29.28941  ? 268 TYR A C    1 
ATOM   3534 O  O    . TYR A 1 268 ? 25.54300 27.49600  9.83300  1.000 26.42771  ? 268 TYR A O    1 
ATOM   3535 C  CB   . TYR A 1 268 ? 24.56000 28.72700  12.59500 1.000 32.56999  ? 268 TYR A CB   1 
ATOM   3536 C  CG   . TYR A 1 268 ? 23.67600 28.30800  13.75900 1.000 33.89035  ? 268 TYR A CG   1 
ATOM   3537 C  CD1  . TYR A 1 268 ? 23.48900 26.96600  14.08600 1.000 32.29785  ? 268 TYR A CD1  1 
ATOM   3538 C  CD2  . TYR A 1 268 ? 23.01800 29.26300  14.52500 1.000 30.13986  ? 268 TYR A CD2  1 
ATOM   3539 C  CE1  . TYR A 1 268 ? 22.67600 26.59600  15.14700 1.000 28.93333  ? 268 TYR A CE1  1 
ATOM   3540 C  CE2  . TYR A 1 268 ? 22.20700 28.90200  15.58500 1.000 36.28232  ? 268 TYR A CE2  1 
ATOM   3541 C  CZ   . TYR A 1 268 ? 22.03800 27.56800  15.89200 1.000 32.96008  ? 268 TYR A CZ   1 
ATOM   3542 O  OH   . TYR A 1 268 ? 21.22800 27.21200  16.94600 1.000 31.49573  ? 268 TYR A OH   1 
ATOM   3543 H  H    . TYR A 1 268 ? 26.66400 28.38400  13.79600 1.000 31.89507  ? 268 TYR A H    1 
ATOM   3544 H  HA   . TYR A 1 268 ? 25.29400 26.84700  12.24500 1.000 38.85754  ? 268 TYR A HA   1 
ATOM   3545 H  HB2  . TYR A 1 268 ? 24.97500 29.57000  12.83900 1.000 39.02375  ? 268 TYR A HB2  1 
ATOM   3546 H  HB3  . TYR A 1 268 ? 23.98300 28.85200  11.82600 1.000 39.02375  ? 268 TYR A HB3  1 
ATOM   3547 H  HD1  . TYR A 1 268 ? 23.91500 26.30900  13.58500 1.000 38.69718  ? 268 TYR A HD1  1 
ATOM   3548 H  HD2  . TYR A 1 268 ? 23.12500 30.16400  14.32000 1.000 36.10760  ? 268 TYR A HD2  1 
ATOM   3549 H  HE1  . TYR A 1 268 ? 22.56100 25.69700  15.35600 1.000 34.65976  ? 268 TYR A HE1  1 
ATOM   3550 H  HE2  . TYR A 1 268 ? 21.77700 29.55500  16.08800 1.000 43.47855  ? 268 TYR A HE2  1 
ATOM   3551 H  HH   . TYR A 1 268 ? 20.85500 27.89300  17.26500 1.000 37.73463  ? 268 TYR A HH   1 
ATOM   3552 N  N    . ILE A 1 269 ? 27.17300 28.84000  10.61400 1.000 35.08265  ? 269 ILE A N    1 
ATOM   3553 C  CA   . ILE A 1 269 ? 27.68500 29.13000  9.27500  1.000 35.20437  ? 269 ILE A CA   1 
ATOM   3554 C  C    . ILE A 1 269 ? 28.10700 27.83600  8.58700  1.000 28.83561  ? 269 ILE A C    1 
ATOM   3555 O  O    . ILE A 1 269 ? 27.61300 27.49300  7.50800  1.000 30.25108  ? 269 ILE A O    1 
ATOM   3556 C  CB   . ILE A 1 269 ? 28.85800 30.12400  9.34000  1.000 35.51587  ? 269 ILE A CB   1 
ATOM   3557 C  CG1  . ILE A 1 269 ? 28.41000 31.51200  9.82700  1.000 37.50980  ? 269 ILE A CG1  1 
ATOM   3558 C  CG2  . ILE A 1 269 ? 29.51500 30.24400  7.97200  1.000 35.94739  ? 269 ILE A CG2  1 
ATOM   3559 C  CD1  . ILE A 1 269 ? 27.14600 32.04900  9.18100  1.000 35.45618  ? 269 ILE A CD1  1 
ATOM   3560 H  H    . ILE A 1 269 ? 27.59500 29.23600  11.25100 1.000 42.03894  ? 269 ILE A H    1 
ATOM   3561 H  HA   . ILE A 1 269 ? 26.97400 29.53900  8.75800  1.000 42.18500  ? 269 ILE A HA   1 
ATOM   3562 H  HB   . ILE A 1 269 ? 29.49600 29.77800  9.98400  1.000 42.55881  ? 269 ILE A HB   1 
ATOM   3563 H  HG12 . ILE A 1 269 ? 28.24900 31.46300  10.78200 1.000 44.95153  ? 269 ILE A HG12 1 
ATOM   3564 H  HG13 . ILE A 1 269 ? 29.12100 32.14500  9.64200  1.000 44.95153  ? 269 ILE A HG13 1 
ATOM   3565 H  HG21 . ILE A 1 269 ? 30.05900 31.04700  7.95200  1.000 43.07663  ? 269 ILE A HG21 1 
ATOM   3566 H  HG22 . ILE A 1 269 ? 30.07100 29.46400  7.81900  1.000 43.07663  ? 269 ILE A HG22 1 
ATOM   3567 H  HG23 . ILE A 1 269 ? 28.82400 30.29600  7.29300  1.000 43.07663  ? 269 ILE A HG23 1 
ATOM   3568 H  HD11 . ILE A 1 269 ? 27.05500 32.99000  9.39800  1.000 42.48718  ? 269 ILE A HD11 1 
ATOM   3569 H  HD12 . ILE A 1 269 ? 27.21000 31.93600  8.22000  1.000 42.48718  ? 269 ILE A HD12 1 
ATOM   3570 H  HD13 . ILE A 1 269 ? 26.38300 31.55600  9.52200  1.000 42.48718  ? 269 ILE A HD13 1 
ATOM   3571 N  N    . ASP A 1 270 ? 29.04300 27.10900  9.20300  1.000 31.29740  ? 270 ASP A N    1 
ATOM   3572 C  CA   . ASP A 1 270 ? 29.45000 25.81000  8.67400  1.000 33.26342  ? 270 ASP A CA   1 
ATOM   3573 C  C    . ASP A 1 270 ? 28.24800 24.88800  8.51500  1.000 33.73375  ? 270 ASP A C    1 
ATOM   3574 O  O    . ASP A 1 270 ? 28.07000 24.25000  7.47100  1.000 31.93418  ? 270 ASP A O    1 
ATOM   3575 C  CB   . ASP A 1 270 ? 30.48300 25.16500  9.60000  1.000 34.84516  ? 270 ASP A CB   1 
ATOM   3576 C  CG   . ASP A 1 270 ? 31.86700 25.76000  9.44800  1.000 35.39967  ? 270 ASP A CG   1 
ATOM   3577 O  OD1  . ASP A 1 270 ? 32.07400 26.59600  8.54500  1.000 36.82235  ? 270 ASP A OD1  1 
ATOM   3578 O  OD2  . ASP A 1 270 ? 32.75500 25.38300  10.24500 1.000 41.04988  ? 270 ASP A OD2  1 
ATOM   3579 H  H    . ASP A 1 270 ? 29.45300 27.34300  9.92200  1.000 37.49664  ? 270 ASP A H    1 
ATOM   3580 H  HA   . ASP A 1 270 ? 29.85700 25.94500  7.80400  1.000 39.85587  ? 270 ASP A HA   1 
ATOM   3581 H  HB2  . ASP A 1 270 ? 30.20300 25.29000  10.52000 1.000 41.75395  ? 270 ASP A HB2  1 
ATOM   3582 H  HB3  . ASP A 1 270 ? 30.54100 24.21800  9.39600  1.000 41.75395  ? 270 ASP A HB3  1 
ATOM   3583 N  N    . GLN A 1 271 ? 27.41900 24.79500  9.55700  1.000 27.55938  ? 271 GLN A N    1 
ATOM   3584 C  CA   . GLN A 1 271 ? 26.28200 23.88200  9.53700  1.000 24.74639  ? 271 GLN A CA   1 
ATOM   3585 C  C    . GLN A 1 271 ? 25.39900 24.12300  8.32000  1.000 34.51347  ? 271 GLN A C    1 
ATOM   3586 O  O    . GLN A 1 271 ? 25.08000 23.19100  7.57100  1.000 24.28534  ? 271 GLN A O    1 
ATOM   3587 C  CB   . GLN A 1 271 ? 25.47400 24.04300  10.82300 1.000 27.46079  ? 271 GLN A CB   1 
ATOM   3588 C  CG   . GLN A 1 271 ? 24.60000 22.86100  11.16700 1.000 41.17316  ? 271 GLN A CG   1 
ATOM   3589 C  CD   . GLN A 1 271 ? 24.11800 22.91500  12.60000 1.000 38.75033  ? 271 GLN A CD   1 
ATOM   3590 O  OE1  . GLN A 1 271 ? 24.86200 23.30400  13.50100 1.000 28.98911  ? 271 GLN A OE1  1 
ATOM   3591 N  NE2  . GLN A 1 271 ? 22.87000 22.51500  12.82000 1.000 44.19466  ? 271 GLN A NE2  1 
ATOM   3592 H  H    . GLN A 1 271 ? 27.49300 25.25000  10.28300 1.000 33.01102  ? 271 GLN A H    1 
ATOM   3593 H  HA   . GLN A 1 271 ? 26.61200 22.97100  9.49200  1.000 29.63542  ? 271 GLN A HA   1 
ATOM   3594 H  HB2  . GLN A 1 271 ? 26.09000 24.17600  11.56000 1.000 32.89271  ? 271 GLN A HB2  1 
ATOM   3595 H  HB3  . GLN A 1 271 ? 24.89600 24.81700  10.73000 1.000 32.89271  ? 271 GLN A HB3  1 
ATOM   3596 H  HG2  . GLN A 1 271 ? 23.82300 22.85800  10.58600 1.000 49.34756  ? 271 GLN A HG2  1 
ATOM   3597 H  HG3  . GLN A 1 271 ? 25.10700 22.04300  11.04800 1.000 49.34756  ? 271 GLN A HG3  1 
ATOM   3598 H  HE21 . GLN A 1 271 ? 22.38300 22.24500  12.16500 1.000 52.97336  ? 271 GLN A HE21 1 
ATOM   3599 H  HE22 . GLN A 1 271 ? 22.55000 22.52700  13.61800 1.000 52.97336  ? 271 GLN A HE22 1 
ATOM   3600 N  N    . TRP A 1 272 ? 24.98700 25.37600  8.10900  1.000 24.17974  ? 272 TRP A N    1 
ATOM   3601 C  CA   . TRP A 1 272 ? 24.12400 25.68000  6.97300  1.000 29.01484  ? 272 TRP A CA   1 
ATOM   3602 C  C    . TRP A 1 272 ? 24.76400 25.23300  5.66500  1.000 31.89501  ? 272 TRP A C    1 
ATOM   3603 O  O    . TRP A 1 272 ? 24.07400 24.74000  4.76400  1.000 29.72000  ? 272 TRP A O    1 
ATOM   3604 C  CB   . TRP A 1 272 ? 23.81200 27.17700  6.92500  1.000 30.18102  ? 272 TRP A CB   1 
ATOM   3605 C  CG   . TRP A 1 272 ? 22.87000 27.52800  5.81200  1.000 28.63452  ? 272 TRP A CG   1 
ATOM   3606 C  CD1  . TRP A 1 272 ? 23.12600 28.33800  4.74300  1.000 36.63460  ? 272 TRP A CD1  1 
ATOM   3607 C  CD2  . TRP A 1 272 ? 21.51800 27.07500  5.65800  1.000 32.95898  ? 272 TRP A CD2  1 
ATOM   3608 N  NE1  . TRP A 1 272 ? 22.01900 28.41500  3.93000  1.000 25.39003  ? 272 TRP A NE1  1 
ATOM   3609 C  CE2  . TRP A 1 272 ? 21.01800 27.65100  4.47100  1.000 32.89370  ? 272 TRP A CE2  1 
ATOM   3610 C  CE3  . TRP A 1 272 ? 20.68400 26.23900  6.40800  1.000 28.87130  ? 272 TRP A CE3  1 
ATOM   3611 C  CZ2  . TRP A 1 272 ? 19.72000 27.41800  4.01700  1.000 26.21739  ? 272 TRP A CZ2  1 
ATOM   3612 C  CZ3  . TRP A 1 272 ? 19.39500 26.00900  5.95500  1.000 27.67113  ? 272 TRP A CZ3  1 
ATOM   3613 C  CH2  . TRP A 1 272 ? 18.92700 26.59600  4.77000  1.000 30.72712  ? 272 TRP A CH2  1 
ATOM   3614 H  H    . TRP A 1 272 ? 25.19000 26.05300  8.60000  1.000 28.95545  ? 272 TRP A H    1 
ATOM   3615 H  HA   . TRP A 1 272 ? 23.28700 25.20300  7.08600  1.000 34.75757  ? 272 TRP A HA   1 
ATOM   3616 H  HB2  . TRP A 1 272 ? 23.40300 27.44200  7.76300  1.000 36.15699  ? 272 TRP A HB2  1 
ATOM   3617 H  HB3  . TRP A 1 272 ? 24.63700 27.66800  6.78800  1.000 36.15699  ? 272 TRP A HB3  1 
ATOM   3618 H  HD1  . TRP A 1 272 ? 23.93200 28.77500  4.58700  1.000 43.90128  ? 272 TRP A HD1  1 
ATOM   3619 H  HE1  . TRP A 1 272 ? 21.96400 28.86900  3.20200  1.000 30.40780  ? 272 TRP A HE1  1 
ATOM   3620 H  HE3  . TRP A 1 272 ? 20.98800 25.84600  7.19400  1.000 34.58532  ? 272 TRP A HE3  1 
ATOM   3621 H  HZ2  . TRP A 1 272 ? 19.40500 27.80600  3.23300  1.000 31.40063  ? 272 TRP A HZ2  1 
ATOM   3622 H  HZ3  . TRP A 1 272 ? 18.83000 25.45600  6.44500  1.000 33.14512  ? 272 TRP A HZ3  1 
ATOM   3623 H  HH2  . TRP A 1 272 ? 18.05700 26.42300  4.49000  1.000 36.81231  ? 272 TRP A HH2  1 
ATOM   3624 N  N    . ASN A 1 273 ? 26.08400 25.39800  5.54200  1.000 31.25643  ? 273 ASN A N    1 
ATOM   3625 C  CA   . ASN A 1 273 ? 26.77300 24.96100  4.33200  1.000 34.03052  ? 273 ASN A CA   1 
ATOM   3626 C  C    . ASN A 1 273 ? 26.57700 23.46600  4.09300  1.000 34.91144  ? 273 ASN A C    1 
ATOM   3627 O  O    . ASN A 1 273 ? 26.30800 23.04700  2.96300  1.000 32.50138  ? 273 ASN A O    1 
ATOM   3628 C  CB   . ASN A 1 273 ? 28.26000 25.30700  4.42100  1.000 29.00818  ? 273 ASN A CB   1 
ATOM   3629 C  CG   . ASN A 1 273 ? 28.52700 26.79500  4.24000  1.000 42.90767  ? 273 ASN A CG   1 
ATOM   3630 O  OD1  . ASN A 1 273 ? 27.66400 27.54400  3.77800  1.000 38.20521  ? 273 ASN A OD1  1 
ATOM   3631 N  ND2  . ASN A 1 273 ? 29.72500 27.23200  4.61700  1.000 35.55524  ? 273 ASN A ND2  1 
ATOM   3632 H  H    . ASN A 1 273 ? 26.59400 25.75500  6.13600  1.000 37.44748  ? 273 ASN A H    1 
ATOM   3633 H  HA   . ASN A 1 273 ? 26.40100 25.43500  3.57100  1.000 40.77638  ? 273 ASN A HA   1 
ATOM   3634 H  HB2  . ASN A 1 273 ? 28.59400 25.04600  5.29300  1.000 34.74958  ? 273 ASN A HB2  1 
ATOM   3635 H  HB3  . ASN A 1 273 ? 28.73800 24.82900  3.72500  1.000 34.74958  ? 273 ASN A HB3  1 
ATOM   3636 H  HD21 . ASN A 1 273 ? 30.30000 26.68100  4.94300  1.000 42.60605  ? 273 ASN A HD21 1 
ATOM   3637 H  HD22 . ASN A 1 273 ? 29.92500 28.06400  4.53500  1.000 42.60605  ? 273 ASN A HD22 1 
ATOM   3638 N  N    . LYS A 1 274 ? 26.70100 22.64500  5.14300  1.000 31.67003  ? 274 LYS A N    1 
ATOM   3639 C  CA   . LYS A 1 274 ? 26.47500 21.21000  4.97800  1.000 24.19147  ? 274 LYS A CA   1 
ATOM   3640 C  C    . LYS A 1 274 ? 25.03400 20.91900  4.57600  1.000 26.87219  ? 274 LYS A C    1 
ATOM   3641 O  O    . LYS A 1 274 ? 24.77300 19.99300  3.79800  1.000 32.81652  ? 274 LYS A O    1 
ATOM   3642 C  CB   . LYS A 1 274 ? 26.81400 20.45100  6.26200  1.000 33.22121  ? 274 LYS A CB   1 
ATOM   3643 C  CG   . LYS A 1 274 ? 28.09600 20.87400  6.94800  1.000 39.11784  ? 274 LYS A CG   1 
ATOM   3644 C  CD   . LYS A 1 274 ? 29.28400 20.82700  6.00400  1.000 49.91082  ? 274 LYS A CD   1 
ATOM   3645 C  CE   . LYS A 1 274 ? 29.51800 19.43000  5.45600  1.000 40.60668  ? 274 LYS A CE   1 
ATOM   3646 N  NZ   . LYS A 1 274 ? 30.92700 19.26200  5.00600  1.000 61.87799  ? 274 LYS A NZ   1 
ATOM   3647 H  H    . LYS A 1 274 ? 26.90900 22.89000  5.94100  1.000 37.94380  ? 274 LYS A H    1 
ATOM   3648 H  HA   . LYS A 1 274 ? 27.06800 20.89600  4.27800  1.000 28.96953  ? 274 LYS A HA   1 
ATOM   3649 H  HB2  . LYS A 1 274 ? 26.09000 20.58400  6.89500  1.000 39.80522  ? 274 LYS A HB2  1 
ATOM   3650 H  HB3  . LYS A 1 274 ? 26.89800 19.50900  6.04700  1.000 39.80522  ? 274 LYS A HB3  1 
ATOM   3651 H  HG2  . LYS A 1 274 ? 28.00100 21.78400  7.27000  1.000 46.88117  ? 274 LYS A HG2  1 
ATOM   3652 H  HG3  . LYS A 1 274 ? 28.27400 20.27500  7.69000  1.000 46.88117  ? 274 LYS A HG3  1 
ATOM   3653 H  HD2  . LYS A 1 274 ? 29.12200 21.42200  5.25600  1.000 59.83274  ? 274 LYS A HD2  1 
ATOM   3654 H  HD3  . LYS A 1 274 ? 30.08200 21.10300  6.48200  1.000 59.83274  ? 274 LYS A HD3  1 
ATOM   3655 H  HE2  . LYS A 1 274 ? 29.33800 18.77600  6.15000  1.000 48.66778  ? 274 LYS A HE2  1 
ATOM   3656 H  HE3  . LYS A 1 274 ? 28.93400 19.27900  4.69700  1.000 48.66778  ? 274 LYS A HE3  1 
ATOM   3657 H  HZ1  . LYS A 1 274 ? 31.13000 19.88500  4.40400  1.000 74.19335  ? 274 LYS A HZ1  1 
ATOM   3658 H  HZ2  . LYS A 1 274 ? 31.03600 18.45900  4.63900  1.000 74.19335  ? 274 LYS A HZ2  1 
ATOM   3659 H  HZ3  . LYS A 1 274 ? 31.48000 19.34100  5.70000  1.000 74.19335  ? 274 LYS A HZ3  1 
ATOM   3660 N  N    . VAL A 1 275 ? 24.08500 21.69400  5.10100  1.000 22.24012  ? 275 VAL A N    1 
ATOM   3661 C  CA   . VAL A 1 275 ? 22.68000 21.47500  4.77300  1.000 23.74512  ? 275 VAL A CA   1 
ATOM   3662 C  C    . VAL A 1 275 ? 22.44500 21.67500  3.27900  1.000 31.53051  ? 275 VAL A C    1 
ATOM   3663 O  O    . VAL A 1 275 ? 21.91000 20.79600  2.59400  1.000 27.12751  ? 275 VAL A O    1 
ATOM   3664 C  CB   . VAL A 1 275 ? 21.78400 22.40200  5.61300  1.000 28.33698  ? 275 VAL A CB   1 
ATOM   3665 C  CG1  . VAL A 1 275 ? 20.34500 22.33500  5.13300  1.000 24.88306  ? 275 VAL A CG1  1 
ATOM   3666 C  CG2  . VAL A 1 275 ? 21.87800 22.03900  7.09900  1.000 28.86271  ? 275 VAL A CG2  1 
ATOM   3667 H  H    . VAL A 1 275 ? 24.22800 22.34600  5.64300  1.000 26.62790  ? 275 VAL A H    1 
ATOM   3668 H  HA   . VAL A 1 275 ? 22.45300 20.55700  4.99100  1.000 28.43390  ? 275 VAL A HA   1 
ATOM   3669 H  HB   . VAL A 1 275 ? 22.09300 23.31600  5.50600  1.000 33.94413  ? 275 VAL A HB   1 
ATOM   3670 H  HG11 . VAL A 1 275 ? 19.76400 22.68400  5.82700  1.000 29.79943  ? 275 VAL A HG11 1 
ATOM   3671 H  HG12 . VAL A 1 275 ? 20.25500 22.86900  4.32800  1.000 29.79943  ? 275 VAL A HG12 1 
ATOM   3672 H  HG13 . VAL A 1 275 ? 20.11700 21.41100  4.94500  1.000 29.79943  ? 275 VAL A HG13 1 
ATOM   3673 H  HG21 . VAL A 1 275 ? 21.34300 22.66400  7.61200  1.000 34.57501  ? 275 VAL A HG21 1 
ATOM   3674 H  HG22 . VAL A 1 275 ? 21.54500 21.13600  7.22500  1.000 34.57501  ? 275 VAL A HG22 1 
ATOM   3675 H  HG23 . VAL A 1 275 ? 22.80600 22.09100  7.37900  1.000 34.57501  ? 275 VAL A HG23 1 
ATOM   3676 N  N    . ILE A 1 276 ? 22.84400 22.83500  2.74900  1.000 33.03916  ? 276 ILE A N    1 
ATOM   3677 C  CA   . ILE A 1 276 ? 22.54300 23.13400  1.35200  1.000 32.88374  ? 276 ILE A CA   1 
ATOM   3678 C  C    . ILE A 1 276 ? 23.40700 22.29800  0.41000  1.000 32.23282  ? 276 ILE A C    1 
ATOM   3679 O  O    . ILE A 1 276 ? 22.95500 21.91500  -0.67400 1.000 35.29307  ? 276 ILE A O    1 
ATOM   3680 C  CB   . ILE A 1 276 ? 22.69800 24.64000  1.06800  1.000 42.75940  ? 276 ILE A CB   1 
ATOM   3681 C  CG1  . ILE A 1 276 ? 24.11000 25.12300  1.40700  1.000 36.21425  ? 276 ILE A CG1  1 
ATOM   3682 C  CG2  . ILE A 1 276 ? 21.64900 25.44000  1.83900  1.000 29.14391  ? 276 ILE A CG2  1 
ATOM   3683 C  CD1  . ILE A 1 276 ? 24.36400 26.56200  1.00700  1.000 43.05459  ? 276 ILE A CD1  1 
ATOM   3684 H  H    . ILE A 1 276 ? 23.28000 23.44800  3.16700  1.000 39.58676  ? 276 ILE A H    1 
ATOM   3685 H  HA   . ILE A 1 276 ? 21.61600 22.89500  1.19300  1.000 39.40024  ? 276 ILE A HA   1 
ATOM   3686 H  HB   . ILE A 1 276 ? 22.55600 24.78200  0.11900  1.000 51.25105  ? 276 ILE A HB   1 
ATOM   3687 H  HG12 . ILE A 1 276 ? 24.24400 25.05200  2.36500  1.000 43.39686  ? 276 ILE A HG12 1 
ATOM   3688 H  HG13 . ILE A 1 276 ? 24.75200 24.56600  0.94000  1.000 43.39686  ? 276 ILE A HG13 1 
ATOM   3689 H  HG21 . ILE A 1 276 ? 21.67900 26.36400  1.54700  1.000 34.91245  ? 276 ILE A HG21 1 
ATOM   3690 H  HG22 . ILE A 1 276 ? 20.77300 25.06500  1.66200  1.000 34.91245  ? 276 ILE A HG22 1 
ATOM   3691 H  HG23 . ILE A 1 276 ? 21.84600 25.38600  2.78800  1.000 34.91245  ? 276 ILE A HG23 1 
ATOM   3692 H  HD11 . ILE A 1 276 ? 25.30700 26.75800  1.11900  1.000 51.60527  ? 276 ILE A HD11 1 
ATOM   3693 H  HD12 . ILE A 1 276 ? 24.11000 26.68100  0.07900  1.000 51.60527  ? 276 ILE A HD12 1 
ATOM   3694 H  HD13 . ILE A 1 276 ? 23.83500 27.14500  1.57300  1.000 51.60527  ? 276 ILE A HD13 1 
ATOM   3695 N  N    . GLU A 1 277 ? 24.65300 22.00100  0.79400  1.000 34.40698  ? 277 GLU A N    1 
ATOM   3696 C  CA   . GLU A 1 277 ? 25.49900 21.16900  -0.05600 1.000 39.75200  ? 277 GLU A CA   1 
ATOM   3697 C  C    . GLU A 1 277 ? 24.84100 19.83100  -0.36700 1.000 44.13333  ? 277 GLU A C    1 
ATOM   3698 O  O    . GLU A 1 277 ? 25.03900 19.28000  -1.45500 1.000 45.50066  ? 277 GLU A O    1 
ATOM   3699 C  CB   . GLU A 1 277 ? 26.85200 20.92000  0.61200  1.000 41.65391  ? 277 GLU A CB   1 
ATOM   3700 C  CG   . GLU A 1 277 ? 27.94100 21.90300  0.22900  1.000 52.72031  ? 277 GLU A CG   1 
ATOM   3701 C  CD   . GLU A 1 277 ? 29.16500 21.77600  1.11300  1.000 55.95926  ? 277 GLU A CD   1 
ATOM   3702 O  OE1  . GLU A 1 277 ? 29.53900 20.63100  1.44600  1.000 63.12223  ? 277 GLU A OE1  1 
ATOM   3703 O  OE2  . GLU A 1 277 ? 29.75300 22.81800  1.47500  1.000 66.72669  ? 277 GLU A OE2  1 
ATOM   3704 H  H    . GLU A 1 277 ? 25.02100 22.26300  1.52600  1.000 41.22814  ? 277 GLU A H    1 
ATOM   3705 H  HA   . GLU A 1 277 ? 25.64900 21.64600  -0.88700 1.000 47.64216  ? 277 GLU A HA   1 
ATOM   3706 H  HB2  . GLU A 1 277 ? 26.73500 20.97500  1.57400  1.000 49.92445  ? 277 GLU A HB2  1 
ATOM   3707 H  HB3  . GLU A 1 277 ? 27.15900 20.03400  0.36600  1.000 49.92445  ? 277 GLU A HB3  1 
ATOM   3708 H  HG2  . GLU A 1 277 ? 28.21100 21.73600  -0.68800 1.000 63.20413  ? 277 GLU A HG2  1 
ATOM   3709 H  HG3  . GLU A 1 277 ? 27.59800 22.80600  0.31400  1.000 63.20413  ? 277 GLU A HG3  1 
ATOM   3710 N  N    . GLN A 1 278 ? 24.06100 19.29700  0.57000  1.000 29.87438  ? 278 GLN A N    1 
ATOM   3711 C  CA   . GLN A 1 278 ? 23.50600 17.95500  0.46100  1.000 31.36359  ? 278 GLN A CA   1 
ATOM   3712 C  C    . GLN A 1 278 ? 22.05200 17.94200  0.01400  1.000 38.31006  ? 278 GLN A C    1 
ATOM   3713 O  O    . GLN A 1 278 ? 21.68400 17.14500  -0.85600 1.000 39.65546  ? 278 GLN A O    1 
ATOM   3714 C  CB   . GLN A 1 278 ? 23.64000 17.23900  1.80600  1.000 31.72769  ? 278 GLN A CB   1 
ATOM   3715 C  CG   . GLN A 1 278 ? 25.07500 16.87500  2.14200  1.000 28.34145  ? 278 GLN A CG   1 
ATOM   3716 C  CD   . GLN A 1 278 ? 25.21700 16.26600  3.51700  1.000 39.46877  ? 278 GLN A CD   1 
ATOM   3717 O  OE1  . GLN A 1 278 ? 25.22100 15.04300  3.67300  1.000 31.64824  ? 278 GLN A OE1  1 
ATOM   3718 N  NE2  . GLN A 1 278 ? 25.34100 17.11800  4.52700  1.000 28.68226  ? 278 GLN A NE2  1 
ATOM   3719 H  H    . GLN A 1 278 ? 23.83500 19.70300  1.29400  1.000 35.78901  ? 278 GLN A H    1 
ATOM   3720 H  HA   . GLN A 1 278 ? 24.01000 17.45400  -0.20000 1.000 37.57607  ? 278 GLN A HA   1 
ATOM   3721 H  HB2  . GLN A 1 278 ? 23.30700 17.82100  2.50700  1.000 38.01299  ? 278 GLN A HB2  1 
ATOM   3722 H  HB3  . GLN A 1 278 ? 23.12200 16.42000  1.78000  1.000 38.01299  ? 278 GLN A HB3  1 
ATOM   3723 H  HG2  . GLN A 1 278 ? 25.39700 16.22900  1.49300  1.000 33.94950  ? 278 GLN A HG2  1 
ATOM   3724 H  HG3  . GLN A 1 278 ? 25.62000 17.67700  2.11100  1.000 33.94950  ? 278 GLN A HG3  1 
ATOM   3725 H  HE21 . GLN A 1 278 ? 25.33600 17.96500  4.37800  1.000 34.35848  ? 278 GLN A HE21 1 
ATOM   3726 H  HE22 . GLN A 1 278 ? 25.42500 16.82200  5.33000  1.000 34.35848  ? 278 GLN A HE22 1 
ATOM   3727 N  N    . LEU A 1 279 ? 21.21700 18.81100  0.57800  1.000 31.70314  ? 279 LEU A N    1 
ATOM   3728 C  CA   . LEU A 1 279 ? 19.80700 18.86900  0.22200  1.000 31.00890  ? 279 LEU A CA   1 
ATOM   3729 C  C    . LEU A 1 279 ? 19.50600 19.88700  -0.87000 1.000 31.10233  ? 279 LEU A C    1 
ATOM   3730 O  O    . LEU A 1 279 ? 18.40300 19.86300  -1.42600 1.000 30.60198  ? 279 LEU A O    1 
ATOM   3731 C  CB   . LEU A 1 279 ? 18.96700 19.19600  1.46000  1.000 28.65042  ? 279 LEU A CB   1 
ATOM   3732 C  CG   . LEU A 1 279 ? 19.22900 18.31800  2.68600  1.000 31.68861  ? 279 LEU A CG   1 
ATOM   3733 C  CD1  . LEU A 1 279 ? 18.36400 18.76800  3.85400  1.000 23.98780  ? 279 LEU A CD1  1 
ATOM   3734 C  CD2  . LEU A 1 279 ? 18.98100 16.85000  2.36900  1.000 36.73268  ? 279 LEU A CD2  1 
ATOM   3735 H  H    . LEU A 1 279 ? 21.44900 19.38400  1.17700  1.000 37.98353  ? 279 LEU A H    1 
ATOM   3736 H  HA   . LEU A 1 279 ? 19.53700 17.99700  -0.10600 1.000 37.15045  ? 279 LEU A HA   1 
ATOM   3737 H  HB2  . LEU A 1 279 ? 19.14800 20.11300  1.71800  1.000 34.32027  ? 279 LEU A HB2  1 
ATOM   3738 H  HB3  . LEU A 1 279 ? 18.03100 19.09500  1.22800  1.000 34.32027  ? 279 LEU A HB3  1 
ATOM   3739 H  HG   . LEU A 1 279 ? 20.16000 18.40900  2.94300  1.000 37.96610  ? 279 LEU A HG   1 
ATOM   3740 H  HD11 . LEU A 1 279 ? 18.55300 18.20500  4.62200  1.000 28.72513  ? 279 LEU A HD11 1 
ATOM   3741 H  HD12 . LEU A 1 279 ? 18.57100 19.69200  4.06300  1.000 28.72513  ? 279 LEU A HD12 1 
ATOM   3742 H  HD13 . LEU A 1 279 ? 17.43000 18.68600  3.60500  1.000 28.72513  ? 279 LEU A HD13 1 
ATOM   3743 H  HD21 . LEU A 1 279 ? 19.08700 16.33000  3.18100  1.000 44.01898  ? 279 LEU A HD21 1 
ATOM   3744 H  HD22 . LEU A 1 279 ? 18.07900 16.74900  2.02600  1.000 44.01898  ? 279 LEU A HD22 1 
ATOM   3745 H  HD23 . LEU A 1 279 ? 19.62300 16.55800  1.70300  1.000 44.01898  ? 279 LEU A HD23 1 
ATOM   3746 N  N    . GLY A 1 280 ? 20.44300 20.77600  -1.18400 1.000 37.86592  ? 280 GLY A N    1 
ATOM   3747 C  CA   . GLY A 1 280 ? 20.23900 21.78100  -2.20600 1.000 36.88082  ? 280 GLY A CA   1 
ATOM   3748 C  C    . GLY A 1 280 ? 19.66200 23.07300  -1.64900 1.000 39.45173  ? 280 GLY A C    1 
ATOM   3749 O  O    . GLY A 1 280 ? 19.06800 23.11800  -0.57300 1.000 33.56661  ? 280 GLY A O    1 
ATOM   3750 H  H    . GLY A 1 280 ? 21.21600 20.81300  -0.81000 1.000 45.37886  ? 280 GLY A H    1 
ATOM   3751 H  HA2  . GLY A 1 280 ? 21.08800 21.98400  -2.62900 1.000 44.19675  ? 280 GLY A HA2  1 
ATOM   3752 H  HA3  . GLY A 1 280 ? 19.62700 21.43800  -2.87500 1.000 44.19675  ? 280 GLY A HA3  1 
ATOM   3753 N  N    . THR A 1 281 ? 19.85000 24.14500  -2.41000 1.000 37.38348  ? 281 THR A N    1 
ATOM   3754 C  CA   . THR A 1 281 ? 19.31600 25.43800  -2.00500 1.000 28.30556  ? 281 THR A CA   1 
ATOM   3755 C  C    . THR A 1 281 ? 17.79100 25.36900  -1.94800 1.000 34.26575  ? 281 THR A C    1 
ATOM   3756 O  O    . THR A 1 281 ? 17.16000 24.81800  -2.85700 1.000 35.17087  ? 281 THR A O    1 
ATOM   3757 C  CB   . THR A 1 281 ? 19.75600 26.52900  -2.98300 1.000 42.00883  ? 281 THR A CB   1 
ATOM   3758 O  OG1  . THR A 1 281 ? 21.18400 26.50800  -3.11700 1.000 35.19413  ? 281 THR A OG1  1 
ATOM   3759 C  CG2  . THR A 1 281 ? 19.31200 27.90600  -2.49200 1.000 37.62101  ? 281 THR A CG2  1 
ATOM   3760 H  H    . THR A 1 281 ? 20.27800 24.15100  -3.15600 1.000 44.79994  ? 281 THR A H    1 
ATOM   3761 H  HA   . THR A 1 281 ? 19.64900 25.66800  -1.12400 1.000 33.90643  ? 281 THR A HA   1 
ATOM   3762 H  HB   . THR A 1 281 ? 19.34900 26.37000  -3.84800 1.000 50.35036  ? 281 THR A HB   1 
ATOM   3763 H  HG1  . THR A 1 281 ? 21.52100 27.15800  -2.70600 1.000 42.17272  ? 281 THR A HG1  1 
ATOM   3764 H  HG21 . THR A 1 281 ? 19.64200 28.59400  -3.09000 1.000 45.08498  ? 281 THR A HG21 1 
ATOM   3765 H  HG22 . THR A 1 281 ? 18.34300 27.95100  -2.46400 1.000 45.08498  ? 281 THR A HG22 1 
ATOM   3766 H  HG23 . THR A 1 281 ? 19.66000 28.06900  -1.60100 1.000 45.08498  ? 281 THR A HG23 1 
ATOM   3767 N  N    . PRO A 1 282 ? 17.16300 25.90300  -0.90100 1.000 35.70164  ? 282 PRO A N    1 
ATOM   3768 C  CA   . PRO A 1 282 ? 15.69900 25.82700  -0.80500 1.000 43.23029  ? 282 PRO A CA   1 
ATOM   3769 C  C    . PRO A 1 282 ? 15.02200 26.71200  -1.84600 1.000 45.36328  ? 282 PRO A C    1 
ATOM   3770 O  O    . PRO A 1 282 ? 15.63100 27.60000  -2.44700 1.000 42.63896  ? 282 PRO A O    1 
ATOM   3771 C  CB   . PRO A 1 282 ? 15.40700 26.29700  0.62500  1.000 41.01578  ? 282 PRO A CB   1 
ATOM   3772 C  CG   . PRO A 1 282 ? 16.59000 27.11900  1.01500  1.000 36.27441  ? 282 PRO A CG   1 
ATOM   3773 C  CD   . PRO A 1 282 ? 17.76600 26.52200  0.29600  1.000 37.16980  ? 282 PRO A CD   1 
ATOM   3774 H  HA   . PRO A 1 282 ? 15.39200 24.91300  -0.91300 1.000 51.81610  ? 282 PRO A HA   1 
ATOM   3775 H  HB2  . PRO A 1 282 ? 14.59600 26.83000  0.63800  1.000 49.15869  ? 282 PRO A HB2  1 
ATOM   3776 H  HB3  . PRO A 1 282 ? 15.30900 25.53000  1.21100  1.000 49.15869  ? 282 PRO A HB3  1 
ATOM   3777 H  HG2  . PRO A 1 282 ? 16.45300 28.03900  0.74200  1.000 43.46906  ? 282 PRO A HG2  1 
ATOM   3778 H  HG3  . PRO A 1 282 ? 16.71700 27.07300  1.97600  1.000 43.46906  ? 282 PRO A HG3  1 
ATOM   3779 H  HD2  . PRO A 1 282 ? 18.40100 27.21000  0.04500  1.000 44.54352  ? 282 PRO A HD2  1 
ATOM   3780 H  HD3  . PRO A 1 282 ? 18.20200 25.85300  0.84700  1.000 44.54352  ? 282 PRO A HD3  1 
ATOM   3781 N  N    . CYS A 1 283 ? 13.70600 26.47800  -2.02500 1.000 50.15073  ? 283 CYS A N    1 
ATOM   3782 C  CA   . CYS A 1 283 ? 12.95700 27.16700  -3.06800 1.000 56.03713  ? 283 CYS A CA   1 
ATOM   3783 C  C    . CYS A 1 283 ? 12.62000 28.59100  -2.63700 1.000 56.62073  ? 283 CYS A C    1 
ATOM   3784 O  O    . CYS A 1 283 ? 12.52800 28.88100  -1.44100 1.000 51.62261  ? 283 CYS A O    1 
ATOM   3785 C  CB   . CYS A 1 283 ? 11.66700 26.41900  -3.39000 1.000 57.79496  ? 283 CYS A CB   1 
ATOM   3786 S  SG   . CYS A 1 283 ? 11.86400 24.90300  -4.34200 1.000 88.37929  ? 283 CYS A SG   1 
ATOM   3787 H  H    . CYS A 1 283 ? 13.23800 25.92900  -1.55700 1.000 60.12064  ? 283 CYS A H    1 
ATOM   3788 H  HA   . CYS A 1 283 ? 13.49700 27.20600  -3.87300 1.000 67.18431  ? 283 CYS A HA   1 
ATOM   3789 H  HB2  . CYS A 1 283 ? 11.23700 26.18100  -2.55400 1.000 69.29371  ? 283 CYS A HB2  1 
ATOM   3790 H  HB3  . CYS A 1 283 ? 11.09300 27.00900  -3.90300 1.000 69.29371  ? 283 CYS A HB3  1 
ATOM   3791 H  HG   . CYS A 1 283 ? 10.82100 24.31100  -4.35500 1.000 105.99491 ? 283 CYS A HG   1 
ATOM   3792 N  N    . PRO A 1 284 ? 12.46200 29.51200  -3.60300 1.000 63.55934  ? 284 PRO A N    1 
ATOM   3793 C  CA   . PRO A 1 284 ? 12.01700 30.86500  -3.25900 1.000 53.14313  ? 284 PRO A CA   1 
ATOM   3794 C  C    . PRO A 1 284 ? 10.89900 30.91600  -2.23400 1.000 49.62183  ? 284 PRO A C    1 
ATOM   3795 O  O    . PRO A 1 284 ? 10.94400 31.75700  -1.33400 1.000 56.02761  ? 284 PRO A O    1 
ATOM   3796 C  CB   . PRO A 1 284 ? 11.56400 31.42000  -4.61800 1.000 67.58014  ? 284 PRO A CB   1 
ATOM   3797 C  CG   . PRO A 1 284 ? 12.41100 30.66300  -5.64400 1.000 60.91413  ? 284 PRO A CG   1 
ATOM   3798 C  CD   . PRO A 1 284 ? 13.10100 29.50900  -4.92800 1.000 66.42607  ? 284 PRO A CD   1 
ATOM   3799 H  HA   . PRO A 1 284 ? 12.76400 31.37700  -2.91200 1.000 63.71152  ? 284 PRO A HA   1 
ATOM   3800 H  HB2  . PRO A 1 284 ? 10.61900 31.24600  -4.74900 1.000 81.03593  ? 284 PRO A HB2  1 
ATOM   3801 H  HB3  . PRO A 1 284 ? 11.73500 32.37400  -4.66000 1.000 81.03593  ? 284 PRO A HB3  1 
ATOM   3802 H  HG2  . PRO A 1 284 ? 11.83400 30.32600  -6.34600 1.000 73.03672  ? 284 PRO A HG2  1 
ATOM   3803 H  HG3  . PRO A 1 284 ? 13.07100 31.26700  -6.01900 1.000 73.03672  ? 284 PRO A HG3  1 
ATOM   3804 H  HD2  . PRO A 1 284 ? 12.94000 28.67000  -5.38800 1.000 79.65105  ? 284 PRO A HD2  1 
ATOM   3805 H  HD3  . PRO A 1 284 ? 14.05500 29.66800  -4.85300 1.000 79.65105  ? 284 PRO A HD3  1 
ATOM   3806 N  N    . GLU A 1 285 ? 9.90400  30.02700  -2.34100 1.000 54.24664  ? 285 GLU A N    1 
ATOM   3807 C  CA   . GLU A 1 285 ? 8.82000  30.00700  -1.36100 1.000 52.91414  ? 285 GLU A CA   1 
ATOM   3808 C  C    . GLU A 1 285 ? 9.35400  29.96800  0.06600  1.000 55.29072  ? 285 GLU A C    1 
ATOM   3809 O  O    . GLU A 1 285 ? 8.75700  30.55600  0.97400  1.000 59.19279  ? 285 GLU A O    1 
ATOM   3810 C  CB   . GLU A 1 285 ? 7.90500  28.80500  -1.61300 1.000 46.49873  ? 285 GLU A CB   1 
ATOM   3811 H  H    . GLU A 1 285 ? 9.83600  29.43700  -2.96200 1.000 65.03573  ? 285 GLU A H    1 
ATOM   3812 H  HA   . GLU A 1 285 ? 8.29100  30.81300  -1.46400 1.000 63.43672  ? 285 GLU A HA   1 
ATOM   3813 N  N    . PHE A 1 286 ? 10.48000 29.28200  0.27600  1.000 52.46700  ? 286 PHE A N    1 
ATOM   3814 C  CA   . PHE A 1 286 ? 11.10300 29.24400  1.59500  1.000 47.73875  ? 286 PHE A CA   1 
ATOM   3815 C  C    . PHE A 1 286 ? 11.80700 30.55600  1.91500  1.000 37.67409  ? 286 PHE A C    1 
ATOM   3816 O  O    . PHE A 1 286 ? 11.74300 31.03900  3.05300  1.000 47.21334  ? 286 PHE A O    1 
ATOM   3817 C  CB   . PHE A 1 286 ? 12.08900 28.07800  1.65400  1.000 37.01631  ? 286 PHE A CB   1 
ATOM   3818 C  CG   . PHE A 1 286 ? 12.86500 28.00400  2.92900  1.000 29.51735  ? 286 PHE A CG   1 
ATOM   3819 C  CD1  . PHE A 1 286 ? 12.30600 27.44800  4.06500  1.000 32.23170  ? 286 PHE A CD1  1 
ATOM   3820 C  CD2  . PHE A 1 286 ? 14.16200 28.48200  2.99100  1.000 37.70617  ? 286 PHE A CD2  1 
ATOM   3821 C  CE1  . PHE A 1 286 ? 13.02400 27.37500  5.24300  1.000 38.13818  ? 286 PHE A CE1  1 
ATOM   3822 C  CE2  . PHE A 1 286 ? 14.88600 28.41300  4.16500  1.000 37.18540  ? 286 PHE A CE2  1 
ATOM   3823 C  CZ   . PHE A 1 286 ? 14.31600 27.85900  5.29300  1.000 30.31490  ? 286 PHE A CZ   1 
ATOM   3824 H  H    . PHE A 1 286 ? 10.89900 28.83400  -0.32600 1.000 62.90016  ? 286 PHE A H    1 
ATOM   3825 H  HA   . PHE A 1 286 ? 10.41800 29.10500  2.26800  1.000 57.22626  ? 286 PHE A HA   1 
ATOM   3826 H  HB2  . PHE A 1 286 ? 11.59500 27.24800  1.56000  1.000 44.35933  ? 286 PHE A HB2  1 
ATOM   3827 H  HB3  . PHE A 1 286 ? 12.72300 28.17000  0.92600  1.000 44.35933  ? 286 PHE A HB3  1 
ATOM   3828 H  HD1  . PHE A 1 286 ? 11.43600 27.11900  4.03500  1.000 38.61780  ? 286 PHE A HD1  1 
ATOM   3829 H  HD2  . PHE A 1 286 ? 14.55100 28.85400  2.23300  1.000 45.18717  ? 286 PHE A HD2  1 
ATOM   3830 H  HE1  . PHE A 1 286 ? 12.63800 27.00000  6.00200  1.000 45.70558  ? 286 PHE A HE1  1 
ATOM   3831 H  HE2  . PHE A 1 286 ? 15.75600 28.73900  4.19500  1.000 44.56225  ? 286 PHE A HE2  1 
ATOM   3832 H  HZ   . PHE A 1 286 ? 14.80100 27.81200  6.08500  1.000 36.31764  ? 286 PHE A HZ   1 
ATOM   3833 N  N    . MET A 1 287 ? 12.48300 31.14600  0.92800  1.000 51.05875  ? 287 MET A N    1 
ATOM   3834 C  CA   . MET A 1 287 ? 13.19700 32.39700  1.15500  1.000 51.49229  ? 287 MET A CA   1 
ATOM   3835 C  C    . MET A 1 287 ? 12.27000 33.46100  1.72800  1.000 47.95705  ? 287 MET A C    1 
ATOM   3836 O  O    . MET A 1 287 ? 12.65300 34.21300  2.63000  1.000 45.31110  ? 287 MET A O    1 
ATOM   3837 C  CB   . MET A 1 287 ? 13.82000 32.87800  -0.15500 1.000 52.25983  ? 287 MET A CB   1 
ATOM   3838 C  CG   . MET A 1 287 ? 14.88000 31.94500  -0.74100 1.000 59.26207  ? 287 MET A CG   1 
ATOM   3839 S  SD   . MET A 1 287 ? 15.97400 31.17700  0.46800  1.000 50.74794  ? 287 MET A SD   1 
ATOM   3840 C  CE   . MET A 1 287 ? 17.40100 30.81300  -0.55100 1.000 44.64356  ? 287 MET A CE   1 
ATOM   3841 H  H    . MET A 1 287 ? 12.54200 30.84500  0.12500  1.000 61.21026  ? 287 MET A H    1 
ATOM   3842 H  HA   . MET A 1 287 ? 13.91400 32.23700  1.78900  1.000 61.73050  ? 287 MET A HA   1 
ATOM   3843 H  HB2  . MET A 1 287 ? 13.11500 32.97000  -0.81600 1.000 62.65156  ? 287 MET A HB2  1 
ATOM   3844 H  HB3  . MET A 1 287 ? 14.24200 33.73700  0.00100  1.000 62.65156  ? 287 MET A HB3  1 
ATOM   3845 H  HG2  . MET A 1 287 ? 14.43000 31.23100  -1.21900 1.000 71.05425  ? 287 MET A HG2  1 
ATOM   3846 H  HG3  . MET A 1 287 ? 15.43400 32.45500  -1.35100 1.000 71.05425  ? 287 MET A HG3  1 
ATOM   3847 H  HE1  . MET A 1 287 ? 18.07200 30.37100  -0.00800 1.000 53.51204  ? 287 MET A HE1  1 
ATOM   3848 H  HE2  . MET A 1 287 ? 17.12900 30.23300  -1.27900 1.000 53.51204  ? 287 MET A HE2  1 
ATOM   3849 H  HE3  . MET A 1 287 ? 17.75600 31.64400  -0.90400 1.000 53.51204  ? 287 MET A HE3  1 
ATOM   3850 N  N    . LYS A 1 288 ? 11.02900 33.51500  1.23400  1.000 50.98625  ? 288 LYS A N    1 
ATOM   3851 C  CA   . LYS A 1 288 ? 10.10900 34.58800  1.59800  1.000 52.64995  ? 288 LYS A CA   1 
ATOM   3852 C  C    . LYS A 1 288 ? 9.70500  34.52500  3.06500  1.000 59.69094  ? 288 LYS A C    1 
ATOM   3853 O  O    . LYS A 1 288 ? 9.27400  35.54200  3.62200  1.000 49.14249  ? 288 LYS A O    1 
ATOM   3854 C  CB   . LYS A 1 288 ? 8.86400  34.53500  0.70000  1.000 62.13607  ? 288 LYS A CB   1 
ATOM   3855 C  CG   . LYS A 1 288 ? 9.15100  34.00700  -0.70600 1.000 70.58588  ? 288 LYS A CG   1 
ATOM   3856 C  CD   . LYS A 1 288 ? 7.95600  34.00100  -1.63700 1.000 78.98662  ? 288 LYS A CD   1 
ATOM   3857 C  CE   . LYS A 1 288 ? 8.30400  33.24400  -2.92000 1.000 73.87615  ? 288 LYS A CE   1 
ATOM   3858 N  NZ   . LYS A 1 288 ? 7.72400  33.85900  -4.14100 1.000 70.58318  ? 288 LYS A NZ   1 
ATOM   3859 H  H    . LYS A 1 288 ? 10.69800 32.94000  0.68700  1.000 61.12326  ? 288 LYS A H    1 
ATOM   3860 H  HA   . LYS A 1 288 ? 10.54400 35.44200  1.45100  1.000 63.11970  ? 288 LYS A HA   1 
ATOM   3861 H  HB2  . LYS A 1 288 ? 8.20700  33.95000  1.10900  1.000 74.50304  ? 288 LYS A HB2  1 
ATOM   3862 H  HB3  . LYS A 1 288 ? 8.50200  35.43100  0.61300  1.000 74.50304  ? 288 LYS A HB3  1 
ATOM   3863 H  HG2  . LYS A 1 288 ? 9.83300  34.56500  -1.11200 1.000 84.64282  ? 288 LYS A HG2  1 
ATOM   3864 H  HG3  . LYS A 1 288 ? 9.46800  33.09400  -0.63400 1.000 84.64282  ? 288 LYS A HG3  1 
ATOM   3865 H  HD2  . LYS A 1 288 ? 7.20700  33.55900  -1.20600 1.000 94.72370  ? 288 LYS A HD2  1 
ATOM   3866 H  HD3  . LYS A 1 288 ? 7.71500  34.91200  -1.86700 1.000 94.72370  ? 288 LYS A HD3  1 
ATOM   3867 H  HE2  . LYS A 1 288 ? 9.26800  33.22900  -3.02400 1.000 88.59114  ? 288 LYS A HE2  1 
ATOM   3868 H  HE3  . LYS A 1 288 ? 7.96300  32.33900  -2.85300 1.000 88.59114  ? 288 LYS A HE3  1 
ATOM   3869 H  HZ1  . LYS A 1 288 ? 7.85200  33.32500  -4.84100 1.000 84.63958  ? 288 LYS A HZ1  1 
ATOM   3870 H  HZ2  . LYS A 1 288 ? 6.85000  33.98700  -4.03100 1.000 84.63958  ? 288 LYS A HZ2  1 
ATOM   3871 H  HZ3  . LYS A 1 288 ? 8.11300  34.64400  -4.30000 1.000 84.63958  ? 288 LYS A HZ3  1 
ATOM   3872 N  N    . LYS A 1 289 ? 9.83300  33.35800  3.69800  1.000 52.86857  ? 289 LYS A N    1 
ATOM   3873 C  CA   . LYS A 1 289 ? 9.60700  33.21900  5.13000  1.000 55.49321  ? 289 LYS A CA   1 
ATOM   3874 C  C    . LYS A 1 289 ? 10.70100 33.87700  5.95700  1.000 52.07170  ? 289 LYS A C    1 
ATOM   3875 O  O    . LYS A 1 289 ? 10.51700 34.07000  7.16400  1.000 52.50696  ? 289 LYS A O    1 
ATOM   3876 C  CB   . LYS A 1 289 ? 9.54400  31.73900  5.51200  1.000 57.15169  ? 289 LYS A CB   1 
ATOM   3877 C  CG   . LYS A 1 289 ? 8.24200  31.01200  5.21300  1.000 62.84482  ? 289 LYS A CG   1 
ATOM   3878 C  CD   . LYS A 1 289 ? 8.56900  29.59200  4.74800  1.000 73.66989  ? 289 LYS A CD   1 
ATOM   3879 C  CE   . LYS A 1 289 ? 7.34300  28.76400  4.39100  1.000 66.69421  ? 289 LYS A CE   1 
ATOM   3880 N  NZ   . LYS A 1 289 ? 6.76100  28.05600  5.56900  1.000 48.01683  ? 289 LYS A NZ   1 
ATOM   3881 H  H    . LYS A 1 289 ? 10.05400 32.62100  3.31300  1.000 63.38204  ? 289 LYS A H    1 
ATOM   3882 H  HA   . LYS A 1 289 ? 8.75600  33.63400  5.34300  1.000 66.53161  ? 289 LYS A HA   1 
ATOM   3883 H  HB2  . LYS A 1 289 ? 10.24600 31.27400  5.02900  1.000 68.52179  ? 289 LYS A HB2  1 
ATOM   3884 H  HB3  . LYS A 1 289 ? 9.69600  31.66800  6.46700  1.000 68.52179  ? 289 LYS A HB3  1 
ATOM   3885 H  HG2  . LYS A 1 289 ? 7.69600  30.96500  6.01300  1.000 75.35354  ? 289 LYS A HG2  1 
ATOM   3886 H  HG3  . LYS A 1 289 ? 7.75900  31.47200  4.50900  1.000 75.35354  ? 289 LYS A HG3  1 
ATOM   3887 H  HD2  . LYS A 1 289 ? 9.12900  29.64300  3.95800  1.000 88.34363  ? 289 LYS A HD2  1 
ATOM   3888 H  HD3  . LYS A 1 289 ? 9.03900  29.13100  5.46000  1.000 88.34363  ? 289 LYS A HD3  1 
ATOM   3889 H  HE2  . LYS A 1 289 ? 6.66100  29.34900  4.02700  1.000 79.97282  ? 289 LYS A HE2  1 
ATOM   3890 H  HE3  . LYS A 1 289 ? 7.59200  28.09600  3.73400  1.000 79.97282  ? 289 LYS A HE3  1 
ATOM   3891 H  HZ1  . LYS A 1 289 ? 6.07300  27.55300  5.31200  1.000 57.55996  ? 289 LYS A HZ1  1 
ATOM   3892 H  HZ2  . LYS A 1 289 ? 7.37600  27.53400  5.94500  1.000 57.55996  ? 289 LYS A HZ2  1 
ATOM   3893 H  HZ3  . LYS A 1 289 ? 6.47800  28.64800  6.17000  1.000 57.55996  ? 289 LYS A HZ3  1 
ATOM   3894 N  N    . LEU A 1 290 ? 11.83100 34.20800  5.34000  1.000 47.09019  ? 290 LEU A N    1 
ATOM   3895 C  CA   . LEU A 1 290 ? 13.02300 34.60800  6.07000  1.000 46.08488  ? 290 LEU A CA   1 
ATOM   3896 C  C    . LEU A 1 290 ? 12.97600 36.09400  6.40200  1.000 49.17061  ? 290 LEU A C    1 
ATOM   3897 O  O    . LEU A 1 290 ? 12.51800 36.90800  5.59600  1.000 56.23741  ? 290 LEU A O    1 
ATOM   3898 C  CB   . LEU A 1 290 ? 14.26700 34.29300  5.23700  1.000 45.45056  ? 290 LEU A CB   1 
ATOM   3899 C  CG   . LEU A 1 290 ? 14.58400 32.81200  4.97900  1.000 45.01978  ? 290 LEU A CG   1 
ATOM   3900 C  CD1  . LEU A 1 290 ? 15.96700 32.65800  4.36100  1.000 41.24403  ? 290 LEU A CD1  1 
ATOM   3901 C  CD2  . LEU A 1 290 ? 14.48800 31.98000  6.24900  1.000 48.26481  ? 290 LEU A CD2  1 
ATOM   3902 H  H    . LEU A 1 290 ? 11.93200 34.20900  4.48600  1.000 56.44799  ? 290 LEU A H    1 
ATOM   3903 H  HA   . LEU A 1 290 ? 13.07600 34.11900  6.90600  1.000 55.24162  ? 290 LEU A HA   1 
ATOM   3904 H  HB2  . LEU A 1 290 ? 14.15800 34.71400  4.36900  1.000 54.48043  ? 290 LEU A HB2  1 
ATOM   3905 H  HB3  . LEU A 1 290 ? 15.03500 34.67100  5.69400  1.000 54.48043  ? 290 LEU A HB3  1 
ATOM   3906 H  HG   . LEU A 1 290 ? 13.92200 32.47300  4.35600  1.000 53.96350  ? 290 LEU A HG   1 
ATOM   3907 H  HD11 . LEU A 1 290 ? 16.13900 31.71700  4.20100  1.000 49.43260  ? 290 LEU A HD11 1 
ATOM   3908 H  HD12 . LEU A 1 290 ? 15.99500 33.14600  3.52300  1.000 49.43260  ? 290 LEU A HD12 1 
ATOM   3909 H  HD13 . LEU A 1 290 ? 16.62900 33.01500  4.97400  1.000 49.43260  ? 290 LEU A HD13 1 
ATOM   3910 H  HD21 . LEU A 1 290 ? 14.74100 31.06500  6.04800  1.000 57.85754  ? 290 LEU A HD21 1 
ATOM   3911 H  HD22 . LEU A 1 290 ? 15.08700 32.35000  6.91500  1.000 57.85754  ? 290 LEU A HD22 1 
ATOM   3912 H  HD23 . LEU A 1 290 ? 13.57400 32.00600  6.57500  1.000 57.85754  ? 290 LEU A HD23 1 
ATOM   3913 N  N    . GLN A 1 291 ? 13.44900 36.44300  7.60000  1.000 55.12352  ? 291 GLN A N    1 
ATOM   3914 C  CA   . GLN A 1 291 ? 13.62100 37.84100  7.98000  1.000 57.98991  ? 291 GLN A CA   1 
ATOM   3915 C  C    . GLN A 1 291 ? 14.46300 38.49800  6.89400  1.000 58.84575  ? 291 GLN A C    1 
ATOM   3916 O  O    . GLN A 1 291 ? 15.23800 37.80500  6.22000  1.000 51.98693  ? 291 GLN A O    1 
ATOM   3917 C  CB   . GLN A 1 291 ? 14.28300 37.95800  9.35100  1.000 55.98026  ? 291 GLN A CB   1 
ATOM   3918 C  CG   . GLN A 1 291 ? 13.61400 37.11600  10.42900 1.000 75.64060  ? 291 GLN A CG   1 
ATOM   3919 C  CD   . GLN A 1 291 ? 14.47300 35.94500  10.87500 1.000 70.59391  ? 291 GLN A CD   1 
ATOM   3920 O  OE1  . GLN A 1 291 ? 14.51200 34.90200  10.21900 1.000 56.41620  ? 291 GLN A OE1  1 
ATOM   3921 N  NE2  . GLN A 1 291 ? 15.16500 36.11200  11.99800 1.000 60.77433  ? 291 GLN A NE2  1 
ATOM   3922 H  H    . GLN A 1 291 ? 13.67800 35.88400  8.21200  1.000 66.08798  ? 291 GLN A H    1 
ATOM   3923 H  HA   . GLN A 1 291 ? 12.76700 38.29500  8.05100  1.000 69.52765  ? 291 GLN A HA   1 
ATOM   3924 H  HB2  . GLN A 1 291 ? 15.20500 37.66800  9.27700  1.000 67.11607  ? 291 GLN A HB2  1 
ATOM   3925 H  HB3  . GLN A 1 291 ? 14.24800 38.88500  9.63500  1.000 67.11607  ? 291 GLN A HB3  1 
ATOM   3926 H  HG2  . GLN A 1 291 ? 13.44100 37.67300  11.20400 1.000 90.70848  ? 291 GLN A HG2  1 
ATOM   3927 H  HG3  . GLN A 1 291 ? 12.78100 36.76200  10.08200 1.000 90.70848  ? 291 GLN A HG3  1 
ATOM   3928 H  HE21 . GLN A 1 291 ? 15.11200 36.85400  12.42900 1.000 72.86896  ? 291 GLN A HE21 1 
ATOM   3929 H  HE22 . GLN A 1 291 ? 15.66700 35.47900  12.29200 1.000 72.86896  ? 291 GLN A HE22 1 
ATOM   3930 N  N    . PRO A 1 292 ? 14.39700 39.82500  6.71000  1.000 63.27684  ? 292 PRO A N    1 
ATOM   3931 C  CA   . PRO A 1 292 ? 15.01300 40.37200  5.50300  1.000 49.77305  ? 292 PRO A CA   1 
ATOM   3932 C  C    . PRO A 1 292 ? 16.54300 40.30700  5.52000  1.000 37.49653  ? 292 PRO A C    1 
ATOM   3933 O  O    . PRO A 1 292 ? 17.14000 40.12600  4.45100  1.000 37.43019  ? 292 PRO A O    1 
ATOM   3934 C  CB   . PRO A 1 292 ? 14.48200 41.81300  5.51100  1.000 53.49749  ? 292 PRO A CB   1 
ATOM   3935 C  CG   . PRO A 1 292 ? 14.50500 42.19500  6.99800  1.000 60.54251  ? 292 PRO A CG   1 
ATOM   3936 C  CD   . PRO A 1 292 ? 14.49700 40.83300  7.78400  1.000 57.36645  ? 292 PRO A CD   1 
ATOM   3937 H  HA   . PRO A 1 292 ? 14.70300 39.91400  4.70600  1.000 59.66742  ? 292 PRO A HA   1 
ATOM   3938 H  HB2  . PRO A 1 292 ? 15.06300 42.38900  4.99100  1.000 64.13675  ? 292 PRO A HB2  1 
ATOM   3939 H  HB3  . PRO A 1 292 ? 13.58000 41.84000  5.15400  1.000 64.13675  ? 292 PRO A HB3  1 
ATOM   3940 H  HG2  . PRO A 1 292 ? 15.30800 42.70100  7.19500  1.000 72.59078  ? 292 PRO A HG2  1 
ATOM   3941 H  HG3  . PRO A 1 292 ? 13.71900 42.72100  7.21400  1.000 72.59078  ? 292 PRO A HG3  1 
ATOM   3942 H  HD2  . PRO A 1 292 ? 15.31900 40.72000  8.28700  1.000 68.77950  ? 292 PRO A HD2  1 
ATOM   3943 H  HD3  . PRO A 1 292 ? 13.73300 40.78100  8.37900  1.000 68.77950  ? 292 PRO A HD3  1 
ATOM   3944 N  N    . THR A 1 293 ? 17.18700 40.39800  6.68000  1.000 45.90766  ? 293 THR A N    1 
ATOM   3945 C  CA   . THR A 1 293 ? 18.64300 40.30800  6.72900  1.000 42.17691  ? 293 THR A CA   1 
ATOM   3946 C  C    . THR A 1 293 ? 19.11100 38.87100  6.52000  1.000 44.49452  ? 293 THR A C    1 
ATOM   3947 O  O    . THR A 1 293 ? 19.99900 38.61000  5.69900  1.000 43.61973  ? 293 THR A O    1 
ATOM   3948 C  CB   . THR A 1 293 ? 19.13900 40.85800  8.06400  1.000 50.05518  ? 293 THR A CB   1 
ATOM   3949 O  OG1  . THR A 1 293 ? 18.66800 42.20200  8.23000  1.000 56.28907  ? 293 THR A OG1  1 
ATOM   3950 C  CG2  . THR A 1 293 ? 20.64900 40.85300  8.11500  1.000 51.63724  ? 293 THR A CG2  1 
ATOM   3951 H  H    . THR A 1 293 ? 16.81000 40.51200  7.44500  1.000 55.02895  ? 293 THR A H    1 
ATOM   3952 H  HA   . THR A 1 293 ? 19.02400 40.84600  6.01800  1.000 50.55206  ? 293 THR A HA   1 
ATOM   3953 H  HB   . THR A 1 293 ? 18.80600 40.30200  8.78600  1.000 60.00598  ? 293 THR A HB   1 
ATOM   3954 H  HG1  . THR A 1 293 ? 18.82200 42.46600  9.01200  1.000 67.48664  ? 293 THR A HG1  1 
ATOM   3955 H  HG21 . THR A 1 293 ? 20.95500 41.26600  8.93800  1.000 61.90445  ? 293 THR A HG21 1 
ATOM   3956 H  HG22 . THR A 1 293 ? 20.98000 39.94200  8.07900  1.000 61.90445  ? 293 THR A HG22 1 
ATOM   3957 H  HG23 . THR A 1 293 ? 21.00800 41.34800  7.36200  1.000 61.90445  ? 293 THR A HG23 1 
ATOM   3958 N  N    . VAL A 1 294 ? 18.52100 37.92000  7.25000  1.000 40.25736  ? 294 VAL A N    1 
ATOM   3959 C  CA   . VAL A 1 294 ? 18.91700 36.52200  7.09000  1.000 40.67087  ? 294 VAL A CA   1 
ATOM   3960 C  C    . VAL A 1 294 ? 18.64200 36.05700  5.66500  1.000 34.91436  ? 294 VAL A C    1 
ATOM   3961 O  O    . VAL A 1 294 ? 19.39400 35.25100  5.10300  1.000 35.08081  ? 294 VAL A O    1 
ATOM   3962 C  CB   . VAL A 1 294 ? 18.20000 35.62700  8.12000  1.000 36.66399  ? 294 VAL A CB   1 
ATOM   3963 C  CG1  . VAL A 1 294 ? 18.66900 34.18300  7.97900  1.000 32.82267  ? 294 VAL A CG1  1 
ATOM   3964 C  CG2  . VAL A 1 294 ? 18.44900 36.11900  9.53500  1.000 51.05836  ? 294 VAL A CG2  1 
ATOM   3965 H  H    . VAL A 1 294 ? 17.90300 38.05600  7.83300  1.000 48.24859  ? 294 VAL A H    1 
ATOM   3966 H  HA   . VAL A 1 294 ? 19.87100 36.45600  7.25600  1.000 48.74480  ? 294 VAL A HA   1 
ATOM   3967 H  HB   . VAL A 1 294 ? 17.24500 35.66700  7.95100  1.000 43.93655  ? 294 VAL A HB   1 
ATOM   3968 H  HG11 . VAL A 1 294 ? 18.27200 33.65200  8.68700  1.000 39.32696  ? 294 VAL A HG11 1 
ATOM   3969 H  HG12 . VAL A 1 294 ? 18.39000 33.84400  7.11400  1.000 39.32696  ? 294 VAL A HG12 1 
ATOM   3970 H  HG13 . VAL A 1 294 ? 19.63600 34.15700  8.04900  1.000 39.32696  ? 294 VAL A HG13 1 
ATOM   3971 H  HG21 . VAL A 1 294 ? 17.96300 35.55500  10.15600 1.000 61.20979  ? 294 VAL A HG21 1 
ATOM   3972 H  HG22 . VAL A 1 294 ? 19.40000 36.07500  9.72200  1.000 61.20979  ? 294 VAL A HG22 1 
ATOM   3973 H  HG23 . VAL A 1 294 ? 18.14000 37.03600  9.61000  1.000 61.20979  ? 294 VAL A HG23 1 
ATOM   3974 N  N    . ARG A 1 295 ? 17.55700 36.55100  5.06200  1.000 42.54084  ? 295 ARG A N    1 
ATOM   3975 C  CA   . ARG A 1 295 ? 17.26400 36.23400  3.66700  1.000 36.60410  ? 295 ARG A CA   1 
ATOM   3976 C  C    . ARG A 1 295 ? 18.43600 36.59700  2.76500  1.000 34.82800  ? 295 ARG A C    1 
ATOM   3977 O  O    . ARG A 1 295 ? 18.84000 35.81200  1.90000  1.000 32.66885  ? 295 ARG A O    1 
ATOM   3978 C  CB   . ARG A 1 295 ? 16.00400 36.97700  3.22100  1.000 48.35843  ? 295 ARG A CB   1 
ATOM   3979 C  CG   . ARG A 1 295 ? 15.53900 36.62100  1.82000  1.000 50.78305  ? 295 ARG A CG   1 
ATOM   3980 C  CD   . ARG A 1 295 ? 14.04400 36.83100  1.67400  1.000 54.82056  ? 295 ARG A CD   1 
ATOM   3981 N  NE   . ARG A 1 295 ? 13.60500 36.73000  0.28800  1.000 64.93160  ? 295 ARG A NE   1 
ATOM   3982 C  CZ   . ARG A 1 295 ? 12.44000 37.17700  -0.16400 1.000 73.39867  ? 295 ARG A CZ   1 
ATOM   3983 N  NH1  . ARG A 1 295 ? 11.56300 37.75600  0.64000  1.000 72.44661  ? 295 ARG A NH1  1 
ATOM   3984 N  NH2  . ARG A 1 295 ? 12.14600 37.03400  -1.45400 1.000 67.74217  ? 295 ARG A NH2  1 
ATOM   3985 H  H    . ARG A 1 295 ? 16.98100 37.06800  5.43700  1.000 50.98877  ? 295 ARG A H    1 
ATOM   3986 H  HA   . ARG A 1 295 ? 17.10300 35.28000  3.59100  1.000 43.86468  ? 295 ARG A HA   1 
ATOM   3987 H  HB2  . ARG A 1 295 ? 15.28400 36.76400  3.83400  1.000 57.96988  ? 295 ARG A HB2  1 
ATOM   3988 H  HB3  . ARG A 1 295 ? 16.18400 37.93000  3.23800  1.000 57.96988  ? 295 ARG A HB3  1 
ATOM   3989 H  HG2  . ARG A 1 295 ? 15.99300 37.18500  1.17500  1.000 60.87942  ? 295 ARG A HG2  1 
ATOM   3990 H  HG3  . ARG A 1 295 ? 15.73700 35.68800  1.64200  1.000 60.87942  ? 295 ARG A HG3  1 
ATOM   3991 H  HD2  . ARG A 1 295 ? 13.57600 36.15500  2.18900  1.000 65.72443  ? 295 ARG A HD2  1 
ATOM   3992 H  HD3  . ARG A 1 295 ? 13.81400 37.71500  2.00000  1.000 65.72443  ? 295 ARG A HD3  1 
ATOM   3993 H  HE   . ARG A 1 295 ? 14.13700 36.35700  -0.27500 1.000 77.85768  ? 295 ARG A HE   1 
ATOM   3994 H  HH11 . ARG A 1 295 ? 11.74200 37.85100  1.47600  1.000 86.87570  ? 295 ARG A HH11 1 
ATOM   3995 H  HH12 . ARG A 1 295 ? 10.81300 38.03800  0.32600  1.000 86.87570  ? 295 ARG A HH12 1 
ATOM   3996 H  HH21 . ARG A 1 295 ? 12.70900 36.65700  -1.98300 1.000 81.23036  ? 295 ARG A HH21 1 
ATOM   3997 H  HH22 . ARG A 1 295 ? 11.39400 37.32000  -1.75700 1.000 81.23036  ? 295 ARG A HH22 1 
ATOM   3998 N  N    . ASN A 1 296 ? 18.98900 37.79600  2.95000  1.000 45.91686  ? 296 ASN A N    1 
ATOM   3999 C  CA   . ASN A 1 296 ? 20.09200 38.25000  2.11100  1.000 39.01377  ? 296 ASN A CA   1 
ATOM   4000 C  C    . ASN A 1 296 ? 21.28100 37.30200  2.20700  1.000 35.11296  ? 296 ASN A C    1 
ATOM   4001 O  O    . ASN A 1 296 ? 21.85200 36.89600  1.18900  1.000 34.85375  ? 296 ASN A O    1 
ATOM   4002 C  CB   . ASN A 1 296 ? 20.49100 39.67000  2.52000  1.000 33.95090  ? 296 ASN A CB   1 
ATOM   4003 C  CG   . ASN A 1 296 ? 21.72500 40.16200  1.79600  1.000 43.98071  ? 296 ASN A CG   1 
ATOM   4004 O  OD1  . ASN A 1 296 ? 22.84300 39.74100  2.09000  1.000 49.38850  ? 296 ASN A OD1  1 
ATOM   4005 N  ND2  . ASN A 1 296 ? 21.52800 41.06200  0.84200  1.000 57.70131  ? 296 ASN A ND2  1 
ATOM   4006 H  H    . ASN A 1 296 ? 18.74500 38.36100  3.55100  1.000 55.03999  ? 296 ASN A H    1 
ATOM   4007 H  HA   . ASN A 1 296 ? 19.80400 38.26900  1.18500  1.000 46.75629  ? 296 ASN A HA   1 
ATOM   4008 H  HB2  . ASN A 1 296 ? 19.76200 40.27500  2.31500  1.000 40.68084  ? 296 ASN A HB2  1 
ATOM   4009 H  HB3  . ASN A 1 296 ? 20.67700 39.68500  3.47200  1.000 40.68084  ? 296 ASN A HB3  1 
ATOM   4010 H  HD21 . ASN A 1 296 ? 20.73200 41.33400  0.66400  1.000 69.18134  ? 296 ASN A HD21 1 
ATOM   4011 H  HD22 . ASN A 1 296 ? 22.19700 41.37300  0.40000  1.000 69.18134  ? 296 ASN A HD22 1 
ATOM   4012 N  N    . TYR A 1 297 ? 21.66600 36.93600  3.43200  1.000 34.35541  ? 297 TYR A N    1 
ATOM   4013 C  CA   . TYR A 1 297 ? 22.77300 36.00400  3.62200  1.000 34.55327  ? 297 TYR A CA   1 
ATOM   4014 C  C    . TYR A 1 297 ? 22.49500 34.66800  2.94400  1.000 28.39447  ? 297 TYR A C    1 
ATOM   4015 O  O    . TYR A 1 297 ? 23.36800 34.11500  2.26200  1.000 32.79300  ? 297 TYR A O    1 
ATOM   4016 C  CB   . TYR A 1 297 ? 23.02200 35.81600  5.12300  1.000 36.04978  ? 297 TYR A CB   1 
ATOM   4017 C  CG   . TYR A 1 297 ? 23.72400 34.53300  5.50400  1.000 33.11430  ? 297 TYR A CG   1 
ATOM   4018 C  CD1  . TYR A 1 297 ? 25.03300 34.28200  5.11000  1.000 36.66399  ? 297 TYR A CD1  1 
ATOM   4019 C  CD2  . TYR A 1 297 ? 23.08000 33.58100  6.28200  1.000 40.31654  ? 297 TYR A CD2  1 
ATOM   4020 C  CE1  . TYR A 1 297 ? 25.67200 33.10300  5.47000  1.000 39.71410  ? 297 TYR A CE1  1 
ATOM   4021 C  CE2  . TYR A 1 297 ? 23.70800 32.40900  6.64900  1.000 45.99602  ? 297 TYR A CE2  1 
ATOM   4022 C  CZ   . TYR A 1 297 ? 25.00300 32.17300  6.24100  1.000 54.49133  ? 297 TYR A CZ   1 
ATOM   4023 O  OH   . TYR A 1 297 ? 25.62000 30.99900  6.61400  1.000 55.17629  ? 297 TYR A OH   1 
ATOM   4024 H  H    . TYR A 1 297 ? 21.30400 37.21100  4.16200  1.000 41.16626  ? 297 TYR A H    1 
ATOM   4025 H  HA   . TYR A 1 297 ? 23.57700 36.37000  3.22200  1.000 41.40369  ? 297 TYR A HA   1 
ATOM   4026 H  HB2  . TYR A 1 297 ? 23.57100 36.55100  5.43700  1.000 43.19950  ? 297 TYR A HB2  1 
ATOM   4027 H  HB3  . TYR A 1 297 ? 22.16600 35.82400  5.57900  1.000 43.19950  ? 297 TYR A HB3  1 
ATOM   4028 H  HD1  . TYR A 1 297 ? 25.48700 34.91200  4.59800  1.000 43.93655  ? 297 TYR A HD1  1 
ATOM   4029 H  HD2  . TYR A 1 297 ? 22.20700 33.73600  6.56300  1.000 48.31961  ? 297 TYR A HD2  1 
ATOM   4030 H  HE1  . TYR A 1 297 ? 26.54500 32.94100  5.19400  1.000 47.59669  ? 297 TYR A HE1  1 
ATOM   4031 H  HE2  . TYR A 1 297 ? 23.26000 31.78200  7.16800  1.000 55.13498  ? 297 TYR A HE2  1 
ATOM   4032 H  HH   . TYR A 1 297 ? 25.10200 30.54100  7.09100  1.000 66.15131  ? 297 TYR A HH   1 
ATOM   4033 N  N    . VAL A 1 298 ? 21.28300 34.14000  3.10700  1.000 34.39065  ? 298 VAL A N    1 
ATOM   4034 C  CA   . VAL A 1 298 ? 20.97800 32.80900  2.58900  1.000 28.31550  ? 298 VAL A CA   1 
ATOM   4035 C  C    . VAL A 1 298 ? 20.89800 32.82800  1.06700  1.000 42.04481  ? 298 VAL A C    1 
ATOM   4036 O  O    . VAL A 1 298 ? 21.34600 31.89000  0.39600  1.000 31.89785  ? 298 VAL A O    1 
ATOM   4037 C  CB   . VAL A 1 298 ? 19.67600 32.28500  3.22200  1.000 32.09241  ? 298 VAL A CB   1 
ATOM   4038 C  CG1  . VAL A 1 298 ? 19.11500 31.13400  2.41700  1.000 33.76087  ? 298 VAL A CG1  1 
ATOM   4039 C  CG2  . VAL A 1 298 ? 19.91700 31.85700  4.66700  1.000 28.31351  ? 298 VAL A CG2  1 
ATOM   4040 H  H    . VAL A 1 298 ? 20.62700 34.52600  3.50800  1.000 41.20854  ? 298 VAL A H    1 
ATOM   4041 H  HA   . VAL A 1 298 ? 21.69800 32.20800  2.83600  1.000 33.91836  ? 298 VAL A HA   1 
ATOM   4042 H  HB   . VAL A 1 298 ? 19.02100 33.00000  3.22100  1.000 38.45065  ? 298 VAL A HB   1 
ATOM   4043 H  HG11 . VAL A 1 298 ? 18.45200 30.66900  2.95100  1.000 40.45280  ? 298 VAL A HG11 1 
ATOM   4044 H  HG12 . VAL A 1 298 ? 18.70500 31.48300  1.61000  1.000 40.45280  ? 298 VAL A HG12 1 
ATOM   4045 H  HG13 . VAL A 1 298 ? 19.83700 30.52900  2.18600  1.000 40.45280  ? 298 VAL A HG13 1 
ATOM   4046 H  HG21 . VAL A 1 298 ? 19.07500 31.57700  5.05800  1.000 33.91598  ? 298 VAL A HG21 1 
ATOM   4047 H  HG22 . VAL A 1 298 ? 20.54800 31.12100  4.67700  1.000 33.91598  ? 298 VAL A HG22 1 
ATOM   4048 H  HG23 . VAL A 1 298 ? 20.27900 32.60900  5.16300  1.000 33.91598  ? 298 VAL A HG23 1 
ATOM   4049 N  N    . GLU A 1 299 ? 20.32500 33.89000  0.49500  1.000 35.89214  ? 299 GLU A N    1 
ATOM   4050 C  CA   . GLU A 1 299 ? 20.20000 33.96200  -0.95700 1.000 41.06448  ? 299 GLU A CA   1 
ATOM   4051 C  C    . GLU A 1 299 ? 21.54500 34.20300  -1.62900 1.000 44.38433  ? 299 GLU A C    1 
ATOM   4052 O  O    . GLU A 1 299 ? 21.72500 33.84300  -2.79900 1.000 42.86130  ? 299 GLU A O    1 
ATOM   4053 C  CB   . GLU A 1 299 ? 19.21400 35.06600  -1.34600 1.000 46.34449  ? 299 GLU A CB   1 
ATOM   4054 C  CG   . GLU A 1 299 ? 17.77000 34.59900  -1.43900 1.000 61.44482  ? 299 GLU A CG   1 
ATOM   4055 C  CD   . GLU A 1 299 ? 16.79900 35.74600  -1.64000 1.000 71.66984  ? 299 GLU A CD   1 
ATOM   4056 O  OE1  . GLU A 1 299 ? 17.25400 36.85600  -1.98600 1.000 77.14926  ? 299 GLU A OE1  1 
ATOM   4057 O  OE2  . GLU A 1 299 ? 15.58200 35.53700  -1.45400 1.000 80.82750  ? 299 GLU A OE2  1 
ATOM   4058 H  H    . GLU A 1 299 ? 20.00700 34.56800  0.91800  1.000 43.01032  ? 299 GLU A H    1 
ATOM   4059 H  HA   . GLU A 1 299 ? 19.85000 33.11700  -1.27800 1.000 49.21714  ? 299 GLU A HA   1 
ATOM   4060 H  HB2  . GLU A 1 299 ? 19.25500 35.76800  -0.67800 1.000 55.55315  ? 299 GLU A HB2  1 
ATOM   4061 H  HB3  . GLU A 1 299 ? 19.46800 35.41800  -2.21300 1.000 55.55315  ? 299 GLU A HB3  1 
ATOM   4062 H  HG2  . GLU A 1 299 ? 17.68100 33.99400  -2.19300 1.000 73.67355  ? 299 GLU A HG2  1 
ATOM   4063 H  HG3  . GLU A 1 299 ? 17.53000 34.14300  -0.61800 1.000 73.67355  ? 299 GLU A HG3  1 
ATOM   4064 N  N    . ASN A 1 300 ? 22.49600 34.80800  -0.92100 1.000 40.25404  ? 300 ASN A N    1 
ATOM   4065 C  CA   . ASN A 1 300 ? 23.81300 35.08300  -1.48000 1.000 38.47213  ? 300 ASN A CA   1 
ATOM   4066 C  C    . ASN A 1 300 ? 24.81200 33.96100  -1.23000 1.000 45.24896  ? 300 ASN A C    1 
ATOM   4067 O  O    . ASN A 1 300 ? 25.95000 34.05000  -1.69900 1.000 42.72754  ? 300 ASN A O    1 
ATOM   4068 C  CB   . ASN A 1 300 ? 24.35600 36.40100  -0.91900 1.000 45.90835  ? 300 ASN A CB   1 
ATOM   4069 C  CG   . ASN A 1 300 ? 23.84700 37.60800  -1.68300 1.000 49.14297  ? 300 ASN A CG   1 
ATOM   4070 O  OD1  . ASN A 1 300 ? 24.38900 37.96600  -2.73000 1.000 54.08201  ? 300 ASN A OD1  1 
ATOM   4071 N  ND2  . ASN A 1 300 ? 22.79600 38.23600  -1.16800 1.000 51.61104  ? 300 ASN A ND2  1 
ATOM   4072 H  H    . ASN A 1 300 ? 22.40000 35.07000  -0.10700 1.000 48.24461  ? 300 ASN A H    1 
ATOM   4073 H  HA   . ASN A 1 300 ? 23.72700 35.18600  -2.44100 1.000 46.10631  ? 300 ASN A HA   1 
ATOM   4074 H  HB2  . ASN A 1 300 ? 24.07800 36.49100  0.00600  1.000 55.02978  ? 300 ASN A HB2  1 
ATOM   4075 H  HB3  . ASN A 1 300 ? 25.32400 36.39500  -0.97500 1.000 55.02978  ? 300 ASN A HB3  1 
ATOM   4076 H  HD21 . ASN A 1 300 ? 22.44100 37.95300  -0.43700 1.000 61.87302  ? 300 ASN A HD21 1 
ATOM   4077 H  HD22 . ASN A 1 300 ? 22.47100 38.92600  -1.56500 1.000 61.87302  ? 300 ASN A HD22 1 
ATOM   4078 N  N    . ARG A 1 301 ? 24.41900 32.91500  -0.50700 1.000 44.21226  ? 301 ARG A N    1 
ATOM   4079 C  CA   . ARG A 1 301 ? 25.25300 31.72800  -0.41200 1.000 39.97126  ? 301 ARG A CA   1 
ATOM   4080 C  C    . ARG A 1 301 ? 25.39900 31.08100  -1.79200 1.000 44.47992  ? 301 ARG A C    1 
ATOM   4081 O  O    . ARG A 1 301 ? 24.51300 31.20900  -2.64200 1.000 36.85657  ? 301 ARG A O    1 
ATOM   4082 C  CB   . ARG A 1 301 ? 24.64600 30.72900  0.57100  1.000 39.86390  ? 301 ARG A CB   1 
ATOM   4083 C  CG   . ARG A 1 301 ? 24.99500 30.99800  2.02400  1.000 39.21171  ? 301 ARG A CG   1 
ATOM   4084 C  CD   . ARG A 1 301 ? 26.39900 30.49600  2.32900  1.000 56.15079  ? 301 ARG A CD   1 
ATOM   4085 N  NE   . ARG A 1 301 ? 27.35600 31.57500  2.54700  1.000 64.45317  ? 301 ARG A NE   1 
ATOM   4086 C  CZ   . ARG A 1 301 ? 28.59200 31.39400  2.99500  1.000 70.16784  ? 301 ARG A CZ   1 
ATOM   4087 N  NH1  . ARG A 1 301 ? 29.06800 30.18400  3.24100  1.000 74.42610  ? 301 ARG A NH1  1 
ATOM   4088 N  NH2  . ARG A 1 301 ? 29.37100 32.45300  3.19500  1.000 57.60301  ? 301 ARG A NH2  1 
ATOM   4089 H  H    . ARG A 1 301 ? 23.68100 32.86900  -0.06700 1.000 52.99447  ? 301 ARG A H    1 
ATOM   4090 H  HA   . ARG A 1 301 ? 26.13600 31.97200  -0.09100 1.000 47.90527  ? 301 ARG A HA   1 
ATOM   4091 H  HB2  . ARG A 1 301 ? 23.68000 30.76100  0.48900  1.000 47.77644  ? 301 ARG A HB2  1 
ATOM   4092 H  HB3  . ARG A 1 301 ? 24.96800 29.84100  0.35000  1.000 47.77644  ? 301 ARG A HB3  1 
ATOM   4093 H  HG2  . ARG A 1 301 ? 24.96300 31.95200  2.19600  1.000 46.99381  ? 301 ARG A HG2  1 
ATOM   4094 H  HG3  . ARG A 1 301 ? 24.36800 30.53600  2.60200  1.000 46.99381  ? 301 ARG A HG3  1 
ATOM   4095 H  HD2  . ARG A 1 301 ? 26.37300 29.95400  3.13300  1.000 67.32071  ? 301 ARG A HD2  1 
ATOM   4096 H  HD3  . ARG A 1 301 ? 26.71400 29.96500  1.58100  1.000 67.32071  ? 301 ARG A HD3  1 
ATOM   4097 H  HE   . ARG A 1 301 ? 27.10400 32.37900  2.37400  1.000 77.28356  ? 301 ARG A HE   1 
ATOM   4098 H  HH11 . ARG A 1 301 ? 28.57300 29.49300  3.11100  1.000 89.25109  ? 301 ARG A HH11 1 
ATOM   4099 H  HH12 . ARG A 1 301 ? 29.87200 30.08900  3.53100  1.000 89.25109  ? 301 ARG A HH12 1 
ATOM   4100 H  HH21 . ARG A 1 301 ? 29.07300 33.24300  3.03400  1.000 69.06337  ? 301 ARG A HH21 1 
ATOM   4101 H  HH22 . ARG A 1 301 ? 30.17400 32.34700  3.48500  1.000 69.06337  ? 301 ARG A HH22 1 
ATOM   4102 N  N    . PRO A 1 302 ? 26.51300 30.39300  -2.04700 1.000 36.42724  ? 302 PRO A N    1 
ATOM   4103 C  CA   . PRO A 1 302 ? 26.64100 29.66200  -3.31400 1.000 50.18685  ? 302 PRO A CA   1 
ATOM   4104 C  C    . PRO A 1 302 ? 25.49200 28.68200  -3.49800 1.000 53.57571  ? 302 PRO A C    1 
ATOM   4105 O  O    . PRO A 1 302 ? 25.08500 27.99100  -2.56100 1.000 55.43600  ? 302 PRO A O    1 
ATOM   4106 C  CB   . PRO A 1 302 ? 27.98600 28.94000  -3.17700 1.000 50.84250  ? 302 PRO A CB   1 
ATOM   4107 C  CG   . PRO A 1 302 ? 28.76500 29.76300  -2.21100 1.000 53.25521  ? 302 PRO A CG   1 
ATOM   4108 C  CD   . PRO A 1 302 ? 27.76900 30.39000  -1.27200 1.000 41.69870  ? 302 PRO A CD   1 
ATOM   4109 H  HA   . PRO A 1 302 ? 26.67700 30.27400  -4.06700 1.000 60.16398  ? 302 PRO A HA   1 
ATOM   4110 H  HB2  . PRO A 1 302 ? 27.84600 28.04300  -2.83500 1.000 60.95076  ? 302 PRO A HB2  1 
ATOM   4111 H  HB3  . PRO A 1 302 ? 28.43100 28.90200  -4.03800 1.000 60.95076  ? 302 PRO A HB3  1 
ATOM   4112 H  HG2  . PRO A 1 302 ? 29.38100 29.19400  -1.72300 1.000 63.84601  ? 302 PRO A HG2  1 
ATOM   4113 H  HG3  . PRO A 1 302 ? 29.25700 30.44800  -2.69200 1.000 63.84601  ? 302 PRO A HG3  1 
ATOM   4114 H  HD2  . PRO A 1 302 ? 27.67400 29.85700  -0.46700 1.000 49.97820  ? 302 PRO A HD2  1 
ATOM   4115 H  HD3  . PRO A 1 302 ? 28.03400 31.29400  -1.04300 1.000 49.97820  ? 302 PRO A HD3  1 
ATOM   4116 N  N    . LYS A 1 303 ? 24.96700 28.63000  -4.71900 1.000 48.80591  ? 303 LYS A N    1 
ATOM   4117 C  CA   . LYS A 1 303 ? 23.81000 27.80200  -5.03300 1.000 53.50361  ? 303 LYS A CA   1 
ATOM   4118 C  C    . LYS A 1 303 ? 24.25700 26.39500  -5.41400 1.000 48.57631  ? 303 LYS A C    1 
ATOM   4119 O  O    . LYS A 1 303 ? 25.08100 26.22400  -6.31800 1.000 64.09152  ? 303 LYS A O    1 
ATOM   4120 C  CB   . LYS A 1 303 ? 23.00500 28.43500  -6.17100 1.000 51.15699  ? 303 LYS A CB   1 
ATOM   4121 C  CG   . LYS A 1 303 ? 21.77100 27.65000  -6.60000 1.000 60.30318  ? 303 LYS A CG   1 
ATOM   4122 C  CD   . LYS A 1 303 ? 20.54300 28.07400  -5.81200 1.000 70.74964  ? 303 LYS A CD   1 
ATOM   4123 C  CE   . LYS A 1 303 ? 19.88000 29.30800  -6.40700 1.000 78.35165  ? 303 LYS A CE   1 
ATOM   4124 N  NZ   . LYS A 1 303 ? 18.57800 29.60900  -5.74300 1.000 65.68898  ? 303 LYS A NZ   1 
ATOM   4125 H  H    . LYS A 1 303 ? 25.26900 29.07300  -5.39100 1.000 58.50685  ? 303 LYS A H    1 
ATOM   4126 H  HA   . LYS A 1 303 ? 23.23900 27.72900  -4.25200 1.000 64.14409  ? 303 LYS A HA   1 
ATOM   4127 H  HB2  . LYS A 1 303 ? 22.70700 29.31200  -5.88500 1.000 61.32815  ? 303 LYS A HB2  1 
ATOM   4128 H  HB3  . LYS A 1 303 ? 23.58200 28.51600  -6.94700 1.000 61.32815  ? 303 LYS A HB3  1 
ATOM   4129 H  HG2  . LYS A 1 303 ? 21.59900 27.80900  -7.54100 1.000 72.30358  ? 303 LYS A HG2  1 
ATOM   4130 H  HG3  . LYS A 1 303 ? 21.92100 26.70400  -6.44500 1.000 72.30358  ? 303 LYS A HG3  1 
ATOM   4131 H  HD2  . LYS A 1 303 ? 19.89600 27.35100  -5.81600 1.000 84.83933  ? 303 LYS A HD2  1 
ATOM   4132 H  HD3  . LYS A 1 303 ? 20.80400 28.28000  -4.90100 1.000 84.83933  ? 303 LYS A HD3  1 
ATOM   4133 H  HE2  . LYS A 1 303 ? 20.46400 30.07300  -6.29000 1.000 93.96175  ? 303 LYS A HE2  1 
ATOM   4134 H  HE3  . LYS A 1 303 ? 19.71300 29.15900  -7.35000 1.000 93.96175  ? 303 LYS A HE3  1 
ATOM   4135 H  HZ1  . LYS A 1 303 ? 18.20300 30.32400  -6.11800 1.000 78.76654  ? 303 LYS A HZ1  1 
ATOM   4136 H  HZ2  . LYS A 1 303 ? 18.02600 28.91600  -5.82800 1.000 78.76654  ? 303 LYS A HZ2  1 
ATOM   4137 H  HZ3  . LYS A 1 303 ? 18.70700 29.77100  -4.87800 1.000 78.76654  ? 303 LYS A HZ3  1 
ATOM   4138 N  N    . TYR A 1 304 ? 23.71300 25.39200  -4.72100 1.000 53.61517  ? 304 TYR A N    1 
ATOM   4139 C  CA   . TYR A 1 304 ? 23.94900 23.99000  -5.03700 1.000 47.95720  ? 304 TYR A CA   1 
ATOM   4140 C  C    . TYR A 1 304 ? 22.64000 23.32000  -5.44200 1.000 47.76942  ? 304 TYR A C    1 
ATOM   4141 O  O    . TYR A 1 304 ? 21.55700 23.71100  -4.99500 1.000 37.44178  ? 304 TYR A O    1 
ATOM   4142 C  CB   . TYR A 1 304 ? 24.54900 23.20800  -3.85300 1.000 47.83552  ? 304 TYR A CB   1 
ATOM   4143 C  CG   . TYR A 1 304 ? 25.69400 23.88100  -3.13100 1.000 53.10400  ? 304 TYR A CG   1 
ATOM   4144 C  CD1  . TYR A 1 304 ? 25.46400 24.90700  -2.22400 1.000 58.39571  ? 304 TYR A CD1  1 
ATOM   4145 C  CD2  . TYR A 1 304 ? 27.00500 23.46700  -3.33400 1.000 58.24797  ? 304 TYR A CD2  1 
ATOM   4146 C  CE1  . TYR A 1 304 ? 26.51000 25.51500  -1.55400 1.000 65.44415  ? 304 TYR A CE1  1 
ATOM   4147 C  CE2  . TYR A 1 304 ? 28.05700 24.06900  -2.66900 1.000 63.79461  ? 304 TYR A CE2  1 
ATOM   4148 C  CZ   . TYR A 1 304 ? 27.80300 25.09000  -1.77900 1.000 67.76979  ? 304 TYR A CZ   1 
ATOM   4149 O  OH   . TYR A 1 304 ? 28.84700 25.69200  -1.11200 1.000 78.23387  ? 304 TYR A OH   1 
ATOM   4150 H  H    . TYR A 1 304 ? 23.19100 25.50600  -4.04700 1.000 64.27797  ? 304 TYR A H    1 
ATOM   4151 H  HA   . TYR A 1 304 ? 24.57700 23.95100  -5.77500 1.000 57.48840  ? 304 TYR A HA   1 
ATOM   4152 H  HB2  . TYR A 1 304 ? 23.84700 23.05900  -3.20100 1.000 57.34238  ? 304 TYR A HB2  1 
ATOM   4153 H  HB3  . TYR A 1 304 ? 24.87900 22.35900  -4.18600 1.000 57.34238  ? 304 TYR A HB3  1 
ATOM   4154 H  HD1  . TYR A 1 304 ? 24.59300 25.19000  -2.06600 1.000 70.01461  ? 304 TYR A HD1  1 
ATOM   4155 H  HD2  . TYR A 1 304 ? 27.17800 22.77300  -3.92800 1.000 69.83733  ? 304 TYR A HD2  1 
ATOM   4156 H  HE1  . TYR A 1 304 ? 26.34200 26.20600  -0.95400 1.000 78.47274  ? 304 TYR A HE1  1 
ATOM   4157 H  HE2  . TYR A 1 304 ? 28.92900 23.78600  -2.82200 1.000 76.49329  ? 304 TYR A HE2  1 
ATOM   4158 H  HH   . TYR A 1 304 ? 29.55300 25.25300  -1.22900 1.000 93.82041  ? 304 TYR A HH   1 
ATOM   4159 N  N    . ALA A 1 305 ? 22.75700 22.28900  -6.28300 1.000 51.07339  ? 305 ALA A N    1 
ATOM   4160 C  CA   . ALA A 1 305 ? 21.58000 21.57700  -6.76400 1.000 49.01922  ? 305 ALA A CA   1 
ATOM   4161 C  C    . ALA A 1 305 ? 21.06800 20.55900  -5.75400 1.000 48.04200  ? 305 ALA A C    1 
ATOM   4162 O  O    . ALA A 1 305 ? 19.86900 20.25800  -5.73900 1.000 44.74804  ? 305 ALA A O    1 
ATOM   4163 C  CB   . ALA A 1 305 ? 21.89600 20.87800  -8.08600 1.000 41.76947  ? 305 ALA A CB   1 
ATOM   4164 H  H    . ALA A 1 305 ? 23.50300 21.98600  -6.58500 1.000 61.22782  ? 305 ALA A H    1 
ATOM   4165 H  HA   . ALA A 1 305 ? 20.87300 22.22200  -6.92200 1.000 58.76282  ? 305 ALA A HA   1 
ATOM   4166 H  HB1  . ALA A 1 305 ? 21.10500 20.40700  -8.39200 1.000 50.06313  ? 305 ALA A HB1  1 
ATOM   4167 H  HB2  . ALA A 1 305 ? 22.15800 21.54400  -8.74100 1.000 50.06313  ? 305 ALA A HB2  1 
ATOM   4168 H  HB3  . ALA A 1 305 ? 22.62200 20.24900  -7.94600 1.000 50.06313  ? 305 ALA A HB3  1 
ATOM   4169 N  N    . GLY A 1 306 ? 21.94600 20.01800  -4.91400 1.000 42.45671  ? 306 GLY A N    1 
ATOM   4170 C  CA   . GLY A 1 306 ? 21.53100 19.05200  -3.91800 1.000 45.90537  ? 306 GLY A CA   1 
ATOM   4171 C  C    . GLY A 1 306 ? 21.51000 17.63500  -4.45200 1.000 54.54589  ? 306 GLY A C    1 
ATOM   4172 O  O    . GLY A 1 306 ? 21.11900 17.39800  -5.59800 1.000 46.67865  ? 306 GLY A O    1 
ATOM   4173 H  H    . GLY A 1 306 ? 22.78700 20.19700  -4.90500 1.000 50.88781  ? 306 GLY A H    1 
ATOM   4174 H  HA2  . GLY A 1 306 ? 22.14200 19.08600  -3.16600 1.000 55.02621  ? 306 GLY A HA2  1 
ATOM   4175 H  HA3  . GLY A 1 306 ? 20.63900 19.27500  -3.61000 1.000 55.02621  ? 306 GLY A HA3  1 
ATOM   4176 N  N    . LEU A 1 307 ? 21.93100 16.68700  -3.62000 1.000 40.61093  ? 307 LEU A N    1 
ATOM   4177 C  CA   . LEU A 1 307 ? 21.99000 15.28700  -4.00600 1.000 41.45894  ? 307 LEU A CA   1 
ATOM   4178 C  C    . LEU A 1 307 ? 20.62700 14.62600  -3.84800 1.000 50.00048  ? 307 LEU A C    1 
ATOM   4179 O  O    . LEU A 1 307 ? 19.82800 15.00000  -2.98500 1.000 41.85734  ? 307 LEU A O    1 
ATOM   4180 C  CB   . LEU A 1 307 ? 23.01300 14.54700  -3.14400 1.000 50.36624  ? 307 LEU A CB   1 
ATOM   4181 C  CG   . LEU A 1 307 ? 24.46700 14.54100  -3.61200 1.000 55.09777  ? 307 LEU A CG   1 
ATOM   4182 C  CD1  . LEU A 1 307 ? 25.14600 15.84800  -3.24700 1.000 40.60476  ? 307 LEU A CD1  1 
ATOM   4183 C  CD2  . LEU A 1 307 ? 25.20800 13.36800  -2.99300 1.000 61.55504  ? 307 LEU A CD2  1 
ATOM   4184 H  H    . LEU A 1 307 ? 22.19200 16.83400  -2.81300 1.000 48.67288  ? 307 LEU A H    1 
ATOM   4185 H  HA   . LEU A 1 307 ? 22.25700 15.22100  -4.93600 1.000 49.69049  ? 307 LEU A HA   1 
ATOM   4186 H  HB2  . LEU A 1 307 ? 23.00500 14.95100  -2.26300 1.000 60.37925  ? 307 LEU A HB2  1 
ATOM   4187 H  HB3  . LEU A 1 307 ? 22.73500 13.61900  -3.08700 1.000 60.37925  ? 307 LEU A HB3  1 
ATOM   4188 H  HG   . LEU A 1 307 ? 24.49300 14.44800  -4.57700 1.000 66.05709  ? 307 LEU A HG   1 
ATOM   4189 H  HD11 . LEU A 1 307 ? 26.06600 15.82100  -3.55100 1.000 48.66547  ? 307 LEU A HD11 1 
ATOM   4190 H  HD12 . LEU A 1 307 ? 24.67600 16.57900  -3.67800 1.000 48.66547  ? 307 LEU A HD12 1 
ATOM   4191 H  HD13 . LEU A 1 307 ? 25.11900 15.95900  -2.28400 1.000 48.66547  ? 307 LEU A HD13 1 
ATOM   4192 H  HD21 . LEU A 1 307 ? 26.12900 13.37900  -3.29800 1.000 73.80581  ? 307 LEU A HD21 1 
ATOM   4193 H  HD22 . LEU A 1 307 ? 25.17900 13.45100  -2.02700 1.000 73.80581  ? 307 LEU A HD22 1 
ATOM   4194 H  HD23 . LEU A 1 307 ? 24.77900 12.54300  -3.26700 1.000 73.80581  ? 307 LEU A HD23 1 
ATOM   4195 N  N    . THR A 1 308 ? 20.36400 13.62800  -4.69000 1.000 43.11564  ? 308 THR A N    1 
ATOM   4196 C  CA   . THR A 1 308 ? 19.20100 12.78700  -4.46500 1.000 37.21753  ? 308 THR A CA   1 
ATOM   4197 C  C    . THR A 1 308 ? 19.44300 11.90400  -3.24300 1.000 35.11809  ? 308 THR A C    1 
ATOM   4198 O  O    . THR A 1 308 ? 20.57800 11.71400  -2.79400 1.000 39.88159  ? 308 THR A O    1 
ATOM   4199 C  CB   . THR A 1 308 ? 18.89300 11.91800  -5.68500 1.000 37.19579  ? 308 THR A CB   1 
ATOM   4200 O  OG1  . THR A 1 308 ? 19.80500 10.81600  -5.72800 1.000 39.14321  ? 308 THR A OG1  1 
ATOM   4201 C  CG2  . THR A 1 308 ? 18.99800 12.72300  -6.97900 1.000 35.69612  ? 308 THR A CG2  1 
ATOM   4202 H  H    . THR A 1 308 ? 20.83500 13.42500  -5.38000 1.000 51.67853  ? 308 THR A H    1 
ATOM   4203 H  HA   . THR A 1 308 ? 18.42300 13.34500  -4.31000 1.000 44.60079  ? 308 THR A HA   1 
ATOM   4204 H  HB   . THR A 1 308 ? 17.98400 11.58600  -5.61800 1.000 44.57470  ? 308 THR A HB   1 
ATOM   4205 H  HG1  . THR A 1 308 ? 19.50800 10.21800  -6.23700 1.000 46.91161  ? 308 THR A HG1  1 
ATOM   4206 H  HG21 . THR A 1 308 ? 18.54500 12.25500  -7.69800 1.000 42.77510  ? 308 THR A HG21 1 
ATOM   4207 H  HG22 . THR A 1 308 ? 18.58700 13.59400  -6.86200 1.000 42.77510  ? 308 THR A HG22 1 
ATOM   4208 H  HG23 . THR A 1 308 ? 19.92900 12.84400  -7.22000 1.000 42.77510  ? 308 THR A HG23 1 
ATOM   4209 N  N    . PHE A 1 309 ? 18.36300 11.36000  -2.70300 1.000 31.97866  ? 309 PHE A N    1 
ATOM   4210 C  CA   . PHE A 1 309 ? 18.47700 10.60900  -1.45900 1.000 36.08482  ? 309 PHE A CA   1 
ATOM   4211 C  C    . PHE A 1 309 ? 19.03500 9.21000   -1.68700 1.000 39.24409  ? 309 PHE A C    1 
ATOM   4212 O  O    . PHE A 1 309 ? 19.65100 8.64600   -0.77300 1.000 35.70876  ? 309 PHE A O    1 
ATOM   4213 C  CB   . PHE A 1 309 ? 17.12400 10.56300  -0.74900 1.000 31.69325  ? 309 PHE A CB   1 
ATOM   4214 C  CG   . PHE A 1 309 ? 16.91100 11.72400  0.18000  1.000 36.59398  ? 309 PHE A CG   1 
ATOM   4215 C  CD1  . PHE A 1 309 ? 17.32500 11.65300  1.49900  1.000 39.82054  ? 309 PHE A CD1  1 
ATOM   4216 C  CD2  . PHE A 1 309 ? 16.34300 12.90200  -0.27700 1.000 31.58211  ? 309 PHE A CD2  1 
ATOM   4217 C  CE1  . PHE A 1 309 ? 17.14900 12.72300  2.35500  1.000 38.00527  ? 309 PHE A CE1  1 
ATOM   4218 C  CE2  . PHE A 1 309 ? 16.16600 13.97900  0.57300  1.000 34.88419  ? 309 PHE A CE2  1 
ATOM   4219 C  CZ   . PHE A 1 309 ? 16.57300 13.89000  1.89100  1.000 39.13924  ? 309 PHE A CZ   1 
ATOM   4220 H  H    . PHE A 1 309 ? 17.56900 11.40900  -3.02900 1.000 38.31415  ? 309 PHE A H    1 
ATOM   4221 H  HA   . PHE A 1 309 ? 19.11400 11.05900  -0.88100 1.000 43.24155  ? 309 PHE A HA   1 
ATOM   4222 H  HB2  . PHE A 1 309 ? 16.41900 10.57900  -1.41500 1.000 37.97166  ? 309 PHE A HB2  1 
ATOM   4223 H  HB3  . PHE A 1 309 ? 17.07000 9.74800   -0.22700 1.000 37.97166  ? 309 PHE A HB3  1 
ATOM   4224 H  HD1  . PHE A 1 309 ? 17.72700 10.87600  1.81300  1.000 47.72441  ? 309 PHE A HD1  1 
ATOM   4225 H  HD2  . PHE A 1 309 ? 16.07700 12.96900  -1.16600 1.000 37.83829  ? 309 PHE A HD2  1 
ATOM   4226 H  HE1  . PHE A 1 309 ? 17.41900 12.65800  3.24300  1.000 45.54608  ? 309 PHE A HE1  1 
ATOM   4227 H  HE2  . PHE A 1 309 ? 15.77400 14.76200  0.25800  1.000 41.80079  ? 309 PHE A HE2  1 
ATOM   4228 H  HZ   . PHE A 1 309 ? 16.46000 14.61400  2.46400  1.000 46.90685  ? 309 PHE A HZ   1 
ATOM   4229 N  N    . PRO A 1 310 ? 18.85200 8.60600   -2.86800 1.000 36.05678  ? 310 PRO A N    1 
ATOM   4230 C  CA   . PRO A 1 310 ? 19.65300 7.41100   -3.17700 1.000 40.70775  ? 310 PRO A CA   1 
ATOM   4231 C  C    . PRO A 1 310 ? 21.14700 7.66500   -3.09100 1.000 34.00833  ? 310 PRO A C    1 
ATOM   4232 O  O    . PRO A 1 310 ? 21.89700 6.78700   -2.64900 1.000 36.37959  ? 310 PRO A O    1 
ATOM   4233 C  CB   . PRO A 1 310 ? 19.20400 7.05800   -4.60300 1.000 34.46216  ? 310 PRO A CB   1 
ATOM   4234 C  CG   . PRO A 1 310 ? 17.78300 7.48900   -4.63000 1.000 36.79581  ? 310 PRO A CG   1 
ATOM   4235 C  CD   . PRO A 1 310 ? 17.77200 8.79600   -3.85500 1.000 42.05591  ? 310 PRO A CD   1 
ATOM   4236 H  HA   . PRO A 1 310 ? 19.41700 6.68300   -2.58100 1.000 48.78906  ? 310 PRO A HA   1 
ATOM   4237 H  HB2  . PRO A 1 310 ? 19.73300 7.54600   -5.25300 1.000 41.29436  ? 310 PRO A HB2  1 
ATOM   4238 H  HB3  . PRO A 1 310 ? 19.28700 6.10400   -4.75600 1.000 41.29436  ? 310 PRO A HB3  1 
ATOM   4239 H  HG2  . PRO A 1 310 ? 17.49300 7.62400   -5.54600 1.000 44.09473  ? 310 PRO A HG2  1 
ATOM   4240 H  HG3  . PRO A 1 310 ? 17.22400 6.82400   -4.19900 1.000 44.09473  ? 310 PRO A HG3  1 
ATOM   4241 H  HD2  . PRO A 1 310 ? 17.96500 9.54600   -4.43900 1.000 50.40685  ? 310 PRO A HD2  1 
ATOM   4242 H  HD3  . PRO A 1 310 ? 16.91900 8.93000   -3.41400 1.000 50.40685  ? 310 PRO A HD3  1 
ATOM   4243 N  N    . LYS A 1 311 ? 21.60400 8.84800   -3.50400 1.000 34.25880  ? 311 LYS A N    1 
ATOM   4244 C  CA   . LYS A 1 311 ? 23.02300 9.16800   -3.40400 1.000 44.13426  ? 311 LYS A CA   1 
ATOM   4245 C  C    . LYS A 1 311 ? 23.41100 9.60200   -1.99400 1.000 51.37098  ? 311 LYS A C    1 
ATOM   4246 O  O    . LYS A 1 311 ? 24.53300 9.32400   -1.55500 1.000 46.02133  ? 311 LYS A O    1 
ATOM   4247 C  CB   . LYS A 1 311 ? 23.38900 10.25800  -4.41500 1.000 43.26307  ? 311 LYS A CB   1 
ATOM   4248 C  CG   . LYS A 1 311 ? 22.92700 9.97300   -5.85000 1.000 52.22341  ? 311 LYS A CG   1 
ATOM   4249 C  CD   . LYS A 1 311 ? 23.47900 8.66000   -6.39800 1.000 61.19996  ? 311 LYS A CD   1 
ATOM   4250 C  CE   . LYS A 1 311 ? 24.82300 8.85500   -7.08300 1.000 60.48036  ? 311 LYS A CE   1 
ATOM   4251 N  NZ   . LYS A 1 311 ? 24.67700 9.44600   -8.44100 1.000 52.46860  ? 311 LYS A NZ   1 
ATOM   4252 H  H    . LYS A 1 311 ? 21.11800 9.47300   -3.84000 1.000 41.05032  ? 311 LYS A H    1 
ATOM   4253 H  HA   . LYS A 1 311 ? 23.53900 8.37700   -3.62400 1.000 52.90088  ? 311 LYS A HA   1 
ATOM   4254 H  HB2  . LYS A 1 311 ? 22.97800 11.09100  -4.13400 1.000 51.85545  ? 311 LYS A HB2  1 
ATOM   4255 H  HB3  . LYS A 1 311 ? 24.35400 10.35400  -4.43100 1.000 51.85545  ? 311 LYS A HB3  1 
ATOM   4256 H  HG2  . LYS A 1 311 ? 21.95800 9.92000   -5.86500 1.000 62.60785  ? 311 LYS A HG2  1 
ATOM   4257 H  HG3  . LYS A 1 311 ? 23.22900 10.69000  -6.42800 1.000 62.60785  ? 311 LYS A HG3  1 
ATOM   4258 H  HD2  . LYS A 1 311 ? 23.59800 8.03300   -5.66800 1.000 73.37972  ? 311 LYS A HD2  1 
ATOM   4259 H  HD3  . LYS A 1 311 ? 22.85700 8.29800   -7.04800 1.000 73.37972  ? 311 LYS A HD3  1 
ATOM   4260 H  HE2  . LYS A 1 311 ? 25.37000 9.45200   -6.54900 1.000 72.51620  ? 311 LYS A HE2  1 
ATOM   4261 H  HE3  . LYS A 1 311 ? 25.26300 7.99500   -7.17200 1.000 72.51620  ? 311 LYS A HE3  1 
ATOM   4262 H  HZ1  . LYS A 1 311 ? 25.47700 9.53800   -8.82100 1.000 62.90208  ? 311 LYS A HZ1  1 
ATOM   4263 H  HZ2  . LYS A 1 311 ? 24.17400 8.91800   -8.95100 1.000 62.90208  ? 311 LYS A HZ2  1 
ATOM   4264 H  HZ3  . LYS A 1 311 ? 24.29100 10.24600  -8.38500 1.000 62.90208  ? 311 LYS A HZ3  1 
ATOM   4265 N  N    . LEU A 1 312 ? 22.50800 10.27000  -1.27100 1.000 48.77204  ? 312 LEU A N    1 
ATOM   4266 C  CA   . LEU A 1 312 ? 22.80500 10.62700  0.11300  1.000 42.01303  ? 312 LEU A CA   1 
ATOM   4267 C  C    . LEU A 1 312 ? 22.83600 9.40100   1.01700  1.000 36.31262  ? 312 LEU A C    1 
ATOM   4268 O  O    . LEU A 1 312 ? 23.60200 9.37000   1.98400  1.000 44.00600  ? 312 LEU A O    1 
ATOM   4269 C  CB   . LEU A 1 312 ? 21.77800 11.63000  0.63800  1.000 32.14165  ? 312 LEU A CB   1 
ATOM   4270 C  CG   . LEU A 1 312 ? 21.89300 13.07800  0.15500  1.000 43.44768  ? 312 LEU A CG   1 
ATOM   4271 C  CD1  . LEU A 1 312 ? 20.63100 13.85700  0.50100  1.000 36.26287  ? 312 LEU A CD1  1 
ATOM   4272 C  CD2  . LEU A 1 312 ? 23.11600 13.75200  0.75800  1.000 36.93417  ? 312 LEU A CD2  1 
ATOM   4273 H  H    . LEU A 1 312 ? 21.73500 10.52000  -1.55300 1.000 58.46621  ? 312 LEU A H    1 
ATOM   4274 H  HA   . LEU A 1 312 ? 23.67800 11.04900  0.13700  1.000 50.35540  ? 312 LEU A HA   1 
ATOM   4275 H  HB2  . LEU A 1 312 ? 20.89800 11.31700  0.37800  1.000 38.50975  ? 312 LEU A HB2  1 
ATOM   4276 H  HB3  . LEU A 1 312 ? 21.85100 11.65100  1.60500  1.000 38.50975  ? 312 LEU A HB3  1 
ATOM   4277 H  HG   . LEU A 1 312 ? 21.99600 13.07900  -0.81000 1.000 52.07698  ? 312 LEU A HG   1 
ATOM   4278 H  HD11 . LEU A 1 312 ? 20.70700 14.75600  0.14500  1.000 43.45520  ? 312 LEU A HD11 1 
ATOM   4279 H  HD12 . LEU A 1 312 ? 19.86500 13.40900  0.10800  1.000 43.45520  ? 312 LEU A HD12 1 
ATOM   4280 H  HD13 . LEU A 1 312 ? 20.53500 13.89000  1.46600  1.000 43.45520  ? 312 LEU A HD13 1 
ATOM   4281 H  HD21 . LEU A 1 312 ? 23.20800 14.63900  0.37700  1.000 44.26077  ? 312 LEU A HD21 1 
ATOM   4282 H  HD22 . LEU A 1 312 ? 22.99900 13.81500  1.71900  1.000 44.26077  ? 312 LEU A HD22 1 
ATOM   4283 H  HD23 . LEU A 1 312 ? 23.90100 13.22100  0.55500  1.000 44.26077  ? 312 LEU A HD23 1 
ATOM   4284 N  N    . PHE A 1 313 ? 22.02000 8.38800   0.72000  1.000 38.76011  ? 313 PHE A N    1 
ATOM   4285 C  CA   . PHE A 1 313 ? 21.89500 7.19300   1.55800  1.000 39.08424  ? 313 PHE A CA   1 
ATOM   4286 C  C    . PHE A 1 313 ? 21.86800 5.96600   0.65700  1.000 45.39438  ? 313 PHE A C    1 
ATOM   4287 O  O    . PHE A 1 313 ? 20.84000 5.29500   0.51600  1.000 31.95895  ? 313 PHE A O    1 
ATOM   4288 C  CB   . PHE A 1 313 ? 20.64000 7.27400   2.42800  1.000 36.67106  ? 313 PHE A CB   1 
ATOM   4289 C  CG   . PHE A 1 313 ? 20.62100 8.46600   3.34100  1.000 39.77394  ? 313 PHE A CG   1 
ATOM   4290 C  CD1  . PHE A 1 313 ? 21.39500 8.48800   4.48800  1.000 37.89264  ? 313 PHE A CD1  1 
ATOM   4291 C  CD2  . PHE A 1 313 ? 19.84400 9.57100   3.04100  1.000 35.61903  ? 313 PHE A CD2  1 
ATOM   4292 C  CE1  . PHE A 1 313 ? 21.38300 9.58800   5.32900  1.000 33.93667  ? 313 PHE A CE1  1 
ATOM   4293 C  CE2  . PHE A 1 313 ? 19.83000 10.67500  3.87500  1.000 36.92247  ? 313 PHE A CE2  1 
ATOM   4294 C  CZ   . PHE A 1 313 ? 20.60100 10.68400  5.01800  1.000 31.19007  ? 313 PHE A CZ   1 
ATOM   4295 H  H    . PHE A 1 313 ? 21.51600 8.37000   0.02300  1.000 46.45189  ? 313 PHE A H    1 
ATOM   4296 H  HA   . PHE A 1 313 ? 22.66700 7.12500   2.14200  1.000 46.84085  ? 313 PHE A HA   1 
ATOM   4297 H  HB2  . PHE A 1 313 ? 19.86200 7.32800   1.85100  1.000 43.94503  ? 313 PHE A HB2  1 
ATOM   4298 H  HB3  . PHE A 1 313 ? 20.58900 6.47700   2.97800  1.000 43.94503  ? 313 PHE A HB3  1 
ATOM   4299 H  HD1  . PHE A 1 313 ? 21.92900 7.75500   4.69700  1.000 45.41093  ? 313 PHE A HD1  1 
ATOM   4300 H  HD2  . PHE A 1 313 ? 19.32500 9.57100   2.26900  1.000 42.68260  ? 313 PHE A HD2  1 
ATOM   4301 H  HE1  . PHE A 1 313 ? 21.90100 9.59000   6.10200  1.000 40.66376  ? 313 PHE A HE1  1 
ATOM   4302 H  HE2  . PHE A 1 313 ? 19.30000 11.41000  3.66500  1.000 44.24673  ? 313 PHE A HE2  1 
ATOM   4303 H  HZ   . PHE A 1 313 ? 20.59400 11.42600  5.57900  1.000 37.36784  ? 313 PHE A HZ   1 
ATOM   4304 N  N    . PRO A 1 314 ? 22.99800 5.64000   0.03200  1.000 37.30256  ? 314 PRO A N    1 
ATOM   4305 C  CA   . PRO A 1 314 ? 23.01700 4.56200   -0.96400 1.000 55.64208  ? 314 PRO A CA   1 
ATOM   4306 C  C    . PRO A 1 314 ? 22.61400 3.21500   -0.38600 1.000 48.67429  ? 314 PRO A C    1 
ATOM   4307 O  O    . PRO A 1 314 ? 22.53500 3.00300   0.82600  1.000 48.98518  ? 314 PRO A O    1 
ATOM   4308 C  CB   . PRO A 1 314 ? 24.47800 4.55500   -1.43700 1.000 52.26617  ? 314 PRO A CB   1 
ATOM   4309 C  CG   . PRO A 1 314 ? 25.22600 5.19300   -0.30000 1.000 63.83416  ? 314 PRO A CG   1 
ATOM   4310 C  CD   . PRO A 1 314 ? 24.30900 6.30200   0.10800  1.000 49.62087  ? 314 PRO A CD   1 
ATOM   4311 H  HA   . PRO A 1 314 ? 22.42100 4.77500   -1.69900 1.000 66.71026  ? 314 PRO A HA   1 
ATOM   4312 H  HB2  . PRO A 1 314 ? 24.77700 3.64500   -1.58700 1.000 62.65916  ? 314 PRO A HB2  1 
ATOM   4313 H  HB3  . PRO A 1 314 ? 24.56900 5.07300   -2.25200 1.000 62.65916  ? 314 PRO A HB3  1 
ATOM   4314 H  HG2  . PRO A 1 314 ? 25.35900 4.55700   0.42000  1.000 76.54075  ? 314 PRO A HG2  1 
ATOM   4315 H  HG3  . PRO A 1 314 ? 26.08300 5.53300   -0.60400 1.000 76.54075  ? 314 PRO A HG3  1 
ATOM   4316 H  HD2  . PRO A 1 314 ? 24.50000 6.60200   1.01100  1.000 59.48481  ? 314 PRO A HD2  1 
ATOM   4317 H  HD3  . PRO A 1 314 ? 24.36300 7.04900   -0.50800 1.000 59.48481  ? 314 PRO A HD3  1 
ATOM   4318 N  N    . ASP A 1 315 ? 22.35800 2.28200   -1.31000 1.000 56.56966  ? 315 ASP A N    1 
ATOM   4319 C  CA   . ASP A 1 315 ? 21.91600 0.94600   -0.93500 1.000 54.49496  ? 315 ASP A CA   1 
ATOM   4320 C  C    . ASP A 1 315 ? 22.89700 0.27200   0.01200  1.000 39.88682  ? 315 ASP A C    1 
ATOM   4321 O  O    . ASP A 1 315 ? 22.49100 -0.52100  0.86900  1.000 45.74487  ? 315 ASP A O    1 
ATOM   4322 C  CB   . ASP A 1 315 ? 21.73700 0.09300   -2.19100 1.000 63.80370  ? 315 ASP A CB   1 
ATOM   4323 C  CG   . ASP A 1 315 ? 20.89000 0.77600   -3.24500 1.000 81.98685  ? 315 ASP A CG   1 
ATOM   4324 O  OD1  . ASP A 1 315 ? 21.30300 1.85600   -3.71600 1.000 84.08820  ? 315 ASP A OD1  1 
ATOM   4325 O  OD2  . ASP A 1 315 ? 19.82600 0.23000   -3.61100 1.000 75.16902  ? 315 ASP A OD2  1 
ATOM   4326 H  H    . ASP A 1 315 ? 22.43500 2.40100   -2.15800 1.000 67.82335  ? 315 ASP A H    1 
ATOM   4327 H  HA   . ASP A 1 315 ? 21.06100 1.01600   -0.48200 1.000 65.33371  ? 315 ASP A HA   1 
ATOM   4328 H  HB2  . ASP A 1 315 ? 22.60800 -0.08800  -2.57700 1.000 76.50420  ? 315 ASP A HB2  1 
ATOM   4329 H  HB3  . ASP A 1 315 ? 21.30200 -0.73900  -1.94900 1.000 76.50420  ? 315 ASP A HB3  1 
ATOM   4330 N  N    . SER A 1 316 ? 24.18800 0.57700   -0.12800 1.000 51.50954  ? 316 SER A N    1 
ATOM   4331 C  CA   . SER A 1 316 ? 25.21500 -0.08300  0.67400  1.000 45.64153  ? 316 SER A CA   1 
ATOM   4332 C  C    . SER A 1 316 ? 24.94300 0.05200   2.16800  1.000 48.31879  ? 316 SER A C    1 
ATOM   4333 O  O    . SER A 1 316 ? 25.21800 -0.87200  2.94300  1.000 43.11872  ? 316 SER A O    1 
ATOM   4334 C  CB   . SER A 1 316 ? 26.58200 0.50800   0.32900  1.000 49.31576  ? 316 SER A CB   1 
ATOM   4335 O  OG   . SER A 1 316 ? 26.65600 0.82300   -1.05100 1.000 61.79800  ? 316 SER A OG   1 
ATOM   4336 H  H    . SER A 1 316 ? 24.49500 1.16100   -0.68000 1.000 61.75121  ? 316 SER A H    1 
ATOM   4337 H  HA   . SER A 1 316 ? 25.21600 -1.02900  0.46200  1.000 54.70960  ? 316 SER A HA   1 
ATOM   4338 H  HB2  . SER A 1 316 ? 26.71800 1.31700   0.84600  1.000 59.11868  ? 316 SER A HB2  1 
ATOM   4339 H  HB3  . SER A 1 316 ? 27.27100 -0.14100  0.54300  1.000 59.11868  ? 316 SER A HB3  1 
ATOM   4340 H  HG   . SER A 1 316 ? 27.27100 1.37800   -1.18700 1.000 74.09736  ? 316 SER A HG   1 
ATOM   4341 N  N    . LEU A 1 317 ? 24.40700 1.19600   2.59300  1.000 40.29194  ? 317 LEU A N    1 
ATOM   4342 C  CA   . LEU A 1 317 ? 24.25000 1.46700   4.01600  1.000 47.34253  ? 317 LEU A CA   1 
ATOM   4343 C  C    . LEU A 1 317 ? 23.11500 0.68200   4.65700  1.000 47.48245  ? 317 LEU A C    1 
ATOM   4344 O  O    . LEU A 1 317 ? 22.96400 0.74300   5.88200  1.000 46.55414  ? 317 LEU A O    1 
ATOM   4345 C  CB   . LEU A 1 317 ? 24.00800 2.96100   4.23900  1.000 40.58065  ? 317 LEU A CB   1 
ATOM   4346 C  CG   . LEU A 1 317 ? 25.07800 3.90500   3.69400  1.000 49.64834  ? 317 LEU A CG   1 
ATOM   4347 C  CD1  . LEU A 1 317 ? 24.58000 5.34500   3.70500  1.000 41.81490  ? 317 LEU A CD1  1 
ATOM   4348 C  CD2  . LEU A 1 317 ? 26.35900 3.76700   4.49800  1.000 47.54644  ? 317 LEU A CD2  1 
ATOM   4349 H  H    . LEU A 1 317 ? 24.12900 1.82600   2.07900  1.000 48.29009  ? 317 LEU A H    1 
ATOM   4350 H  HA   . LEU A 1 317 ? 25.07400 1.21600   4.46100  1.000 56.75079  ? 317 LEU A HA   1 
ATOM   4351 H  HB2  . LEU A 1 317 ? 23.17100 3.19900   3.81100  1.000 48.63654  ? 317 LEU A HB2  1 
ATOM   4352 H  HB3  . LEU A 1 317 ? 23.94800 3.11800   5.19500  1.000 48.63654  ? 317 LEU A HB3  1 
ATOM   4353 H  HG   . LEU A 1 317 ? 25.27400 3.67000   2.77300  1.000 59.51777  ? 317 LEU A HG   1 
ATOM   4354 H  HD11 . LEU A 1 317 ? 25.26900 5.92000   3.33600  1.000 50.11764  ? 317 LEU A HD11 1 
ATOM   4355 H  HD12 . LEU A 1 317 ? 23.77600 5.40500   3.16600  1.000 50.11764  ? 317 LEU A HD12 1 
ATOM   4356 H  HD13 . LEU A 1 317 ? 24.38700 5.60500   4.61900  1.000 50.11764  ? 317 LEU A HD13 1 
ATOM   4357 H  HD21 . LEU A 1 317 ? 27.00500 4.41500   4.17700  1.000 56.99549  ? 317 LEU A HD21 1 
ATOM   4358 H  HD22 . LEU A 1 317 ? 26.16300 3.93200   5.43400  1.000 56.99549  ? 317 LEU A HD22 1 
ATOM   4359 H  HD23 . LEU A 1 317 ? 26.70700 2.86900   4.38600  1.000 56.99549  ? 317 LEU A HD23 1 
ATOM   4360 N  N    . PHE A 1 318 ? 22.32300 -0.05400  3.87500  1.000 51.15596  ? 318 PHE A N    1 
ATOM   4361 C  CA   . PHE A 1 318 ? 21.11800 -0.66100  4.41500  1.000 52.35700  ? 318 PHE A CA   1 
ATOM   4362 C  C    . PHE A 1 318 ? 21.21000 -2.18000  4.39800  1.000 51.34040  ? 318 PHE A C    1 
ATOM   4363 O  O    . PHE A 1 318 ? 21.80500 -2.75900  3.48700  1.000 46.28666  ? 318 PHE A O    1 
ATOM   4364 C  CB   . PHE A 1 318 ? 19.88500 -0.24100  3.60500  1.000 50.65937  ? 318 PHE A CB   1 
ATOM   4365 C  CG   . PHE A 1 318 ? 19.44200 1.16500   3.86200  1.000 45.32680  ? 318 PHE A CG   1 
ATOM   4366 C  CD1  . PHE A 1 318 ? 18.75700 1.48800   5.02000  1.000 44.30271  ? 318 PHE A CD1  1 
ATOM   4367 C  CD2  . PHE A 1 318 ? 19.70200 2.16500   2.94100  1.000 44.18519  ? 318 PHE A CD2  1 
ATOM   4368 C  CE1  . PHE A 1 318 ? 18.34600 2.78400   5.25800  1.000 40.13834  ? 318 PHE A CE1  1 
ATOM   4369 C  CE2  . PHE A 1 318 ? 19.29300 3.45900   3.17200  1.000 40.25897  ? 318 PHE A CE2  1 
ATOM   4370 C  CZ   . PHE A 1 318 ? 18.61300 3.77100   4.33200  1.000 39.21661  ? 318 PHE A CZ   1 
ATOM   4371 H  H    . PHE A 1 318 ? 22.46400 -0.21100  3.04100  1.000 61.32691  ? 318 PHE A H    1 
ATOM   4372 H  HA   . PHE A 1 318 ? 21.00600 -0.37200  5.33400  1.000 62.76817  ? 318 PHE A HA   1 
ATOM   4373 H  HB2  . PHE A 1 318 ? 20.09200 -0.31800  2.66000  1.000 60.73101  ? 318 PHE A HB2  1 
ATOM   4374 H  HB3  . PHE A 1 318 ? 19.14800 -0.83000  3.83100  1.000 60.73101  ? 318 PHE A HB3  1 
ATOM   4375 H  HD1  . PHE A 1 318 ? 18.57200 0.82500   5.64600  1.000 53.10302  ? 318 PHE A HD1  1 
ATOM   4376 H  HD2  . PHE A 1 318 ? 20.15900 1.96000   2.15700  1.000 52.96199  ? 318 PHE A HD2  1 
ATOM   4377 H  HE1  . PHE A 1 318 ? 17.88900 2.99200   6.04100  1.000 48.10577  ? 318 PHE A HE1  1 
ATOM   4378 H  HE2  . PHE A 1 318 ? 19.47500 4.12300   2.54600  1.000 48.25052  ? 318 PHE A HE2  1 
ATOM   4379 H  HZ   . PHE A 1 318 ? 18.33600 4.64400   4.48900  1.000 46.99970  ? 318 PHE A HZ   1 
ATOM   4380 N  N    . PRO A 1 319 ? 20.63500 -2.85500  5.39700  1.000 53.14254  ? 319 PRO A N    1 
ATOM   4381 C  CA   . PRO A 1 319 ? 20.32900 -4.28100  5.22900  1.000 52.75184  ? 319 PRO A CA   1 
ATOM   4382 C  C    . PRO A 1 319 ? 19.42600 -4.46400  4.02000  1.000 54.37209  ? 319 PRO A C    1 
ATOM   4383 O  O    . PRO A 1 319 ? 18.32300 -3.91300  3.95900  1.000 50.18904  ? 319 PRO A O    1 
ATOM   4384 C  CB   . PRO A 1 319 ? 19.62300 -4.65300  6.53800  1.000 55.99721  ? 319 PRO A CB   1 
ATOM   4385 C  CG   . PRO A 1 319 ? 20.08000 -3.63300  7.52600  1.000 48.79519  ? 319 PRO A CG   1 
ATOM   4386 C  CD   . PRO A 1 319 ? 20.29800 -2.36900  6.74900  1.000 54.79205  ? 319 PRO A CD   1 
ATOM   4387 H  HA   . PRO A 1 319 ? 21.13200 -4.81700  5.14200  1.000 63.24197  ? 319 PRO A HA   1 
ATOM   4388 H  HB2  . PRO A 1 319 ? 18.66100 -4.61300  6.41700  1.000 67.13641  ? 319 PRO A HB2  1 
ATOM   4389 H  HB3  . PRO A 1 319 ? 19.88600 -5.54500  6.81300  1.000 67.13641  ? 319 PRO A HB3  1 
ATOM   4390 H  HG2  . PRO A 1 319 ? 19.39700 -3.50600  8.20300  1.000 58.49399  ? 319 PRO A HG2  1 
ATOM   4391 H  HG3  . PRO A 1 319 ? 20.90600 -3.92700  7.94000  1.000 58.49399  ? 319 PRO A HG3  1 
ATOM   4392 H  HD2  . PRO A 1 319 ? 19.49000 -1.83200  6.73100  1.000 65.69022  ? 319 PRO A HD2  1 
ATOM   4393 H  HD3  . PRO A 1 319 ? 21.03000 -1.85500  7.12400  1.000 65.69022  ? 319 PRO A HD3  1 
ATOM   4394 N  N    . ALA A 1 320 ? 19.91300 -5.21900  3.03800  1.000 50.15019  ? 320 ALA A N    1 
ATOM   4395 C  CA   . ALA A 1 320 ? 19.15000 -5.43300  1.81500  1.000 59.50387  ? 320 ALA A CA   1 
ATOM   4396 C  C    . ALA A 1 320 ? 19.57500 -6.72000  1.12300  1.000 56.51416  ? 320 ALA A C    1 
ATOM   4397 O  O    . ALA A 1 320 ? 19.89600 -6.71600  -0.07000 1.000 61.55254  ? 320 ALA A O    1 
ATOM   4398 C  CB   . ALA A 1 320 ? 19.31000 -4.23900  0.87000  1.000 57.92784  ? 320 ALA A CB   1 
ATOM   4399 H  H    . ALA A 1 320 ? 20.67700 -5.61400  3.05600  1.000 60.11999  ? 320 ALA A H    1 
ATOM   4400 H  HA   . ALA A 1 320 ? 18.21000 -5.51500  2.04200  1.000 71.34440  ? 320 ALA A HA   1 
ATOM   4401 H  HB1  . ALA A 1 320 ? 18.79900 -4.40400  0.06300  1.000 69.45317  ? 320 ALA A HB1  1 
ATOM   4402 H  HB2  . ALA A 1 320 ? 18.98100 -3.44000  1.31200  1.000 69.45317  ? 320 ALA A HB2  1 
ATOM   4403 H  HB3  . ALA A 1 320 ? 20.24900 -4.13300  0.65200  1.000 69.45317  ? 320 ALA A HB3  1 
ATOM   4404 N  N    . ASP A 1 321 ? 19.58100 -7.82600  1.86700  1.000 55.16349  ? 321 ASP A N    1 
ATOM   4405 C  CA   . ASP A 1 321 ? 19.83400 -9.15000  1.31200  1.000 61.43469  ? 321 ASP A CA   1 
ATOM   4406 C  C    . ASP A 1 321 ? 18.54200 -9.89300  0.99200  1.000 53.96374  ? 321 ASP A C    1 
ATOM   4407 O  O    . ASP A 1 321 ? 18.39900 -10.44800 -0.10200 1.000 60.30793  ? 321 ASP A O    1 
ATOM   4408 C  CB   . ASP A 1 321 ? 20.68500 -9.97700  2.28500  1.000 64.34132  ? 321 ASP A CB   1 
ATOM   4409 C  CG   . ASP A 1 321 ? 20.10800 -10.00800 3.69000  1.000 72.56089  ? 321 ASP A CG   1 
ATOM   4410 O  OD1  . ASP A 1 321 ? 19.09900 -9.31100  3.93800  1.000 58.50025  ? 321 ASP A OD1  1 
ATOM   4411 O  OD2  . ASP A 1 321 ? 20.66300 -10.72900 4.54600  1.000 67.93398  ? 321 ASP A OD2  1 
ATOM   4412 H  H    . ASP A 1 321 ? 19.43700 -7.83300  2.71500  1.000 66.13595  ? 321 ASP A H    1 
ATOM   4413 H  HA   . ASP A 1 321 ? 20.33900 -9.05300  0.48900  1.000 73.66139  ? 321 ASP A HA   1 
ATOM   4414 H  HB2  . ASP A 1 321 ? 20.73700 -10.89100 1.96300  1.000 77.14935  ? 321 ASP A HB2  1 
ATOM   4415 H  HB3  . ASP A 1 321 ? 21.57400 -9.59200  2.33500  1.000 77.14935  ? 321 ASP A HB3  1 
ATOM   4416 N  N    . SER A 1 322 ? 17.59900 -9.91200  1.92600  1.000 41.66081  ? 322 SER A N    1 
ATOM   4417 C  CA   . SER A 1 322 ? 16.29700 -10.52400 1.71900  1.000 44.47738  ? 322 SER A CA   1 
ATOM   4418 C  C    . SER A 1 322 ? 15.33100 -9.51500  1.10600  1.000 43.53678  ? 322 SER A C    1 
ATOM   4419 O  O    . SER A 1 322 ? 15.53300 -8.30100  1.17800  1.000 35.34482  ? 322 SER A O    1 
ATOM   4420 C  CB   . SER A 1 322 ? 15.73300 -11.04000 3.04300  1.000 36.06157  ? 322 SER A CB   1 
ATOM   4421 O  OG   . SER A 1 322 ? 15.47900 -9.96000  3.93200  1.000 31.36998  ? 322 SER A OG   1 
ATOM   4422 H  H    . SER A 1 322 ? 17.69300 -9.56800  2.70900  1.000 49.93273  ? 322 SER A H    1 
ATOM   4423 H  HA   . SER A 1 322 ? 16.38600 -11.27500 1.11200  1.000 53.31262  ? 322 SER A HA   1 
ATOM   4424 H  HB2  . SER A 1 322 ? 14.90300 -11.51200 2.87100  1.000 43.21364  ? 322 SER A HB2  1 
ATOM   4425 H  HB3  . SER A 1 322 ? 16.37700 -11.64100 3.44900  1.000 43.21364  ? 322 SER A HB3  1 
ATOM   4426 H  HG   . SER A 1 322 ? 15.09000 -10.24100 4.62100  1.000 37.58373  ? 322 SER A HG   1 
ATOM   4427 N  N    . GLU A 1 323 ? 14.26200 -10.03700 0.49900  1.000 32.05171  ? 323 GLU A N    1 
ATOM   4428 C  CA   . GLU A 1 323 ? 13.24200 -9.15300  -0.05600 1.000 40.66147  ? 323 GLU A CA   1 
ATOM   4429 C  C    . GLU A 1 323 ? 12.62900 -8.28000  1.03400  1.000 38.72093  ? 323 GLU A C    1 
ATOM   4430 O  O    . GLU A 1 323 ? 12.32300 -7.10300  0.80400  1.000 24.67355  ? 323 GLU A O    1 
ATOM   4431 C  CB   . GLU A 1 323 ? 12.16800 -9.97600  -0.76600 1.000 39.83386  ? 323 GLU A CB   1 
ATOM   4432 C  CG   . GLU A 1 323 ? 12.68500 -10.75100 -1.97700 1.000 33.45506  ? 323 GLU A CG   1 
ATOM   4433 C  CD   . GLU A 1 323 ? 12.90600 -9.87400  -3.20200 1.000 37.53973  ? 323 GLU A CD   1 
ATOM   4434 O  OE1  . GLU A 1 323 ? 12.62400 -8.65900  -3.13800 1.000 23.07732  ? 323 GLU A OE1  1 
ATOM   4435 O  OE2  . GLU A 1 323 ? 13.36800 -10.40900 -4.23300 1.000 36.82271  ? 323 GLU A OE2  1 
ATOM   4436 H  H    . GLU A 1 323 ? 14.11000 -10.87700 0.39800  1.000 38.40182  ? 323 GLU A H    1 
ATOM   4437 H  HA   . GLU A 1 323 ? 13.64800 -8.56900  -0.71500 1.000 48.73352  ? 323 GLU A HA   1 
ATOM   4438 H  HB2  . GLU A 1 323 ? 11.80200 -10.61800 -0.13800 1.000 47.74039  ? 323 GLU A HB2  1 
ATOM   4439 H  HB3  . GLU A 1 323 ? 11.47000 -9.37800  -1.07300 1.000 47.74039  ? 323 GLU A HB3  1 
ATOM   4440 H  HG2  . GLU A 1 323 ? 13.53300 -11.16300 -1.74900 1.000 40.08584  ? 323 GLU A HG2  1 
ATOM   4441 H  HG3  . GLU A 1 323 ? 12.03800 -11.43400 -2.21300 1.000 40.08584  ? 323 GLU A HG3  1 
ATOM   4442 N  N    . HIS A 1 324 ? 12.45600 -8.83300  2.23700  1.000 29.48860  ? 324 HIS A N    1 
ATOM   4443 C  CA   . HIS A 1 324 ? 11.93400 -8.03200  3.34000  1.000 34.08934  ? 324 HIS A CA   1 
ATOM   4444 C  C    . HIS A 1 324 ? 12.84800 -6.85000  3.63500  1.000 28.14695  ? 324 HIS A C    1 
ATOM   4445 O  O    . HIS A 1 324 ? 12.37500 -5.72700  3.85400  1.000 29.65425  ? 324 HIS A O    1 
ATOM   4446 C  CB   . HIS A 1 324 ? 11.76300 -8.90500  4.58400  1.000 35.82544  ? 324 HIS A CB   1 
ATOM   4447 C  CG   . HIS A 1 324 ? 11.52300 -8.12600  5.84000  1.000 30.49744  ? 324 HIS A CG   1 
ATOM   4448 N  ND1  . HIS A 1 324 ? 12.55000 -7.67100  6.64100  1.000 35.82779  ? 324 HIS A ND1  1 
ATOM   4449 C  CD2  . HIS A 1 324 ? 10.37600 -7.71700  6.43100  1.000 37.34563  ? 324 HIS A CD2  1 
ATOM   4450 C  CE1  . HIS A 1 324 ? 12.04400 -7.01800  7.67300  1.000 33.07160  ? 324 HIS A CE1  1 
ATOM   4451 N  NE2  . HIS A 1 324 ? 10.72700 -7.03200  7.57000  1.000 38.24272  ? 324 HIS A NE2  1 
ATOM   4452 H  H    . HIS A 1 324 ? 12.63000 -9.65100  2.43500  1.000 35.32608  ? 324 HIS A H    1 
ATOM   4453 H  HA   . HIS A 1 324 ? 11.06200 -7.68600  3.09500  1.000 40.84697  ? 324 HIS A HA   1 
ATOM   4454 H  HB2  . HIS A 1 324 ? 11.00200 -9.49200  4.45100  1.000 42.93029  ? 324 HIS A HB2  1 
ATOM   4455 H  HB3  . HIS A 1 324 ? 12.56800 -9.43000  4.71100  1.000 42.93029  ? 324 HIS A HB3  1 
ATOM   4456 H  HD1  . HIS A 1 324 ? 13.38800 -7.79300  6.49300  1.000 42.93311  ? 324 HIS A HD1  1 
ATOM   4457 H  HD2  . HIS A 1 324 ? 9.51100  -7.87100  6.12400  1.000 44.75452  ? 324 HIS A HD2  1 
ATOM   4458 H  HE1  . HIS A 1 324 ? 12.53200 -6.61800  8.35600  1.000 39.62569  ? 324 HIS A HE1  1 
ATOM   4459 N  N    . ASN A 1 325 ? 14.16300 -7.07700  3.62800  1.000 26.53056  ? 325 ASN A N    1 
ATOM   4460 C  CA   . ASN A 1 325 ? 15.10800 -6.00000  3.90100  1.000 31.57560  ? 325 ASN A CA   1 
ATOM   4461 C  C    . ASN A 1 325 ? 15.27000 -5.05600  2.71300  1.000 38.24637  ? 325 ASN A C    1 
ATOM   4462 O  O    . ASN A 1 325 ? 15.50500 -3.85800  2.91500  1.000 27.80450  ? 325 ASN A O    1 
ATOM   4463 C  CB   . ASN A 1 325 ? 16.46000 -6.58900  4.30900  1.000 37.61624  ? 325 ASN A CB   1 
ATOM   4464 C  CG   . ASN A 1 325 ? 16.47500 -7.07200  5.75600  1.000 47.16701  ? 325 ASN A CG   1 
ATOM   4465 O  OD1  . ASN A 1 325 ? 15.55200 -6.80000  6.52400  1.000 38.07032  ? 325 ASN A OD1  1 
ATOM   4466 N  ND2  . ASN A 1 325 ? 17.52600 -7.79200  6.12900  1.000 39.98844  ? 325 ASN A ND2  1 
ATOM   4467 H  H    . ASN A 1 325 ? 14.52800 -7.83900  3.46900  1.000 31.77643  ? 325 ASN A H    1 
ATOM   4468 H  HA   . ASN A 1 325 ? 14.77600 -5.47300  4.64400  1.000 37.83048  ? 325 ASN A HA   1 
ATOM   4469 H  HB2  . ASN A 1 325 ? 16.66200 -7.34600  3.73700  1.000 45.07925  ? 325 ASN A HB2  1 
ATOM   4470 H  HB3  . ASN A 1 325 ? 17.14500 -5.90900  4.21200  1.000 45.07925  ? 325 ASN A HB3  1 
ATOM   4471 H  HD21 . ASN A 1 325 ? 17.58100 -8.08700  6.93500  1.000 47.92589  ? 325 ASN A HD21 1 
ATOM   4472 H  HD22 . ASN A 1 325 ? 18.15300 -7.96400  5.56500  1.000 47.92589  ? 325 ASN A HD22 1 
ATOM   4473 N  N    . LYS A 1 326 ? 15.15000 -5.55400  1.47600  1.000 30.67786  ? 326 LYS A N    1 
ATOM   4474 C  CA   . LYS A 1 326 ? 15.13800 -4.64400  0.33200  1.000 24.88169  ? 326 LYS A CA   1 
ATOM   4475 C  C    . LYS A 1 326 ? 13.98800 -3.65300  0.45300  1.000 21.77272  ? 326 LYS A C    1 
ATOM   4476 O  O    . LYS A 1 326 ? 14.15800 -2.44800  0.22600  1.000 29.12812  ? 326 LYS A O    1 
ATOM   4477 C  CB   . LYS A 1 326 ? 15.01400 -5.41700  -0.98400 1.000 35.87538  ? 326 LYS A CB   1 
ATOM   4478 C  CG   . LYS A 1 326 ? 16.20600 -6.27800  -1.38500 1.000 37.32691  ? 326 LYS A CG   1 
ATOM   4479 C  CD   . LYS A 1 326 ? 15.83900 -7.11600  -2.61200 1.000 43.59170  ? 326 LYS A CD   1 
ATOM   4480 C  CE   . LYS A 1 326 ? 16.89100 -8.16000  -2.97000 1.000 50.24436  ? 326 LYS A CE   1 
ATOM   4481 N  NZ   . LYS A 1 326 ? 18.13600 -7.57200  -3.53900 1.000 50.87016  ? 326 LYS A NZ   1 
ATOM   4482 H  H    . LYS A 1 326 ? 15.07700 -6.38800  1.28100  1.000 36.75320  ? 326 LYS A H    1 
ATOM   4483 H  HA   . LYS A 1 326 ? 15.98100 -4.16500  0.31800  1.000 29.79779  ? 326 LYS A HA   1 
ATOM   4484 H  HB2  . LYS A 1 326 ? 14.24800 -6.00800  -0.91500 1.000 42.99022  ? 326 LYS A HB2  1 
ATOM   4485 H  HB3  . LYS A 1 326 ? 14.87500 -4.77600  -1.69800 1.000 42.99022  ? 326 LYS A HB3  1 
ATOM   4486 H  HG2  . LYS A 1 326 ? 16.96200 -5.71200  -1.60600 1.000 44.73205  ? 326 LYS A HG2  1 
ATOM   4487 H  HG3  . LYS A 1 326 ? 16.44100 -6.87500  -0.65700 1.000 44.73205  ? 326 LYS A HG3  1 
ATOM   4488 H  HD2  . LYS A 1 326 ? 15.00700 -7.58100  -2.43700 1.000 52.24980  ? 326 LYS A HD2  1 
ATOM   4489 H  HD3  . LYS A 1 326 ? 15.73600 -6.52600  -3.37500 1.000 52.24980  ? 326 LYS A HD3  1 
ATOM   4490 H  HE2  . LYS A 1 326 ? 17.13300 -8.65000  -2.16900 1.000 60.23299  ? 326 LYS A HE2  1 
ATOM   4491 H  HE3  . LYS A 1 326 ? 16.52000 -8.76700  -3.63100 1.000 60.23299  ? 326 LYS A HE3  1 
ATOM   4492 H  HZ1  . LYS A 1 326 ? 18.72100 -8.21700  -3.72300 1.000 60.98395  ? 326 LYS A HZ1  1 
ATOM   4493 H  HZ2  . LYS A 1 326 ? 17.94900 -7.12900  -4.28800 1.000 60.98395  ? 326 LYS A HZ2  1 
ATOM   4494 H  HZ3  . LYS A 1 326 ? 18.50100 -7.00900  -2.95500 1.000 60.98395  ? 326 LYS A HZ3  1 
ATOM   4495 N  N    . LEU A 1 327 ? 12.80000 -4.15000  0.80300  1.000 25.38026  ? 327 LEU A N    1 
ATOM   4496 C  CA   . LEU A 1 327 ? 11.62900 -3.28400  0.89600  1.000 24.05685  ? 327 LEU A CA   1 
ATOM   4497 C  C    . LEU A 1 327 ? 11.77700 -2.28200  2.03300  1.000 29.85605  ? 327 LEU A C    1 
ATOM   4498 O  O    . LEU A 1 327 ? 11.41700 -1.10800  1.88500  1.000 25.48124  ? 327 LEU A O    1 
ATOM   4499 C  CB   . LEU A 1 327 ? 10.37200 -4.13300  1.08600  1.000 24.73343  ? 327 LEU A CB   1 
ATOM   4500 C  CG   . LEU A 1 327 ? 9.03200  -3.39800  1.08600  1.000 30.09692  ? 327 LEU A CG   1 
ATOM   4501 C  CD1  . LEU A 1 327 ? 8.83800  -2.62000  -0.20900 1.000 34.74420  ? 327 LEU A CD1  1 
ATOM   4502 C  CD2  . LEU A 1 327 ? 7.89200  -4.38100  1.28900  1.000 34.38732  ? 327 LEU A CD2  1 
ATOM   4503 H  H    . LEU A 1 327 ? 12.64800 -4.97600  0.98800  1.000 30.39608  ? 327 LEU A H    1 
ATOM   4504 H  HA   . LEU A 1 327 ? 11.53600 -2.78600  0.06900  1.000 28.80798  ? 327 LEU A HA   1 
ATOM   4505 H  HB2  . LEU A 1 327 ? 10.33900 -4.78200  0.36600  1.000 29.61988  ? 327 LEU A HB2  1 
ATOM   4506 H  HB3  . LEU A 1 327 ? 10.44600 -4.58800  1.94000  1.000 29.61988  ? 327 LEU A HB3  1 
ATOM   4507 H  HG   . LEU A 1 327 ? 9.02300  -2.76200  1.81900  1.000 36.05607  ? 327 LEU A HG   1 
ATOM   4508 H  HD11 . LEU A 1 327 ? 7.91900  -2.31300  -0.25800 1.000 41.63280  ? 327 LEU A HD11 1 
ATOM   4509 H  HD12 . LEU A 1 327 ? 9.44100  -1.86000  -0.21400 1.000 41.63280  ? 327 LEU A HD12 1 
ATOM   4510 H  HD13 . LEU A 1 327 ? 9.03300  -3.20300  -0.95900 1.000 41.63280  ? 327 LEU A HD13 1 
ATOM   4511 H  HD21 . LEU A 1 327 ? 7.05400  -3.89300  1.30600  1.000 41.20454  ? 327 LEU A HD21 1 
ATOM   4512 H  HD22 . LEU A 1 327 ? 7.89000  -5.01700  0.55800  1.000 41.20454  ? 327 LEU A HD22 1 
ATOM   4513 H  HD23 . LEU A 1 327 ? 8.02200  -4.84500  2.13100  1.000 41.20454  ? 327 LEU A HD23 1 
ATOM   4514 N  N    . LYS A 1 328 ? 12.31300 -2.72300  3.17300  1.000 26.50998  ? 328 LYS A N    1 
ATOM   4515 C  CA   . LYS A 1 328 ? 12.45700 -1.82200  4.31100  1.000 26.29854  ? 328 LYS A CA   1 
ATOM   4516 C  C    . LYS A 1 328 ? 13.49000 -0.73600  4.03700  1.000 21.28429  ? 328 LYS A C    1 
ATOM   4517 O  O    . LYS A 1 328 ? 13.33100 0.39800   4.50100  1.000 30.70871  ? 328 LYS A O    1 
ATOM   4518 C  CB   . LYS A 1 328 ? 12.82600 -2.62100  5.56200  1.000 29.33848  ? 328 LYS A CB   1 
ATOM   4519 C  CG   . LYS A 1 328 ? 11.64300 -3.36200  6.18700  1.000 30.06056  ? 328 LYS A CG   1 
ATOM   4520 C  CD   . LYS A 1 328 ? 10.70000 -2.39900  6.91000  1.000 43.88736  ? 328 LYS A CD   1 
ATOM   4521 C  CE   . LYS A 1 328 ? 9.29500  -2.97100  7.05600  1.000 44.57223  ? 328 LYS A CE   1 
ATOM   4522 N  NZ   . LYS A 1 328 ? 9.07100  -3.59700  8.38900  1.000 53.61553  ? 328 LYS A NZ   1 
ATOM   4523 H  H    . LYS A 1 328 ? 12.59600 -3.52400  3.30900  1.000 31.75174  ? 328 LYS A H    1 
ATOM   4524 H  HA   . LYS A 1 328 ? 11.60800 -1.38400  4.47900  1.000 31.49801  ? 328 LYS A HA   1 
ATOM   4525 H  HB2  . LYS A 1 328 ? 13.49700 -3.28000  5.32500  1.000 35.14594  ? 328 LYS A HB2  1 
ATOM   4526 H  HB3  . LYS A 1 328 ? 13.18000 -2.01100  6.22800  1.000 35.14594  ? 328 LYS A HB3  1 
ATOM   4527 H  HG2  . LYS A 1 328 ? 11.14200 -3.81400  5.49100  1.000 36.01244  ? 328 LYS A HG2  1 
ATOM   4528 H  HG3  . LYS A 1 328 ? 11.97300 -4.00700  6.83200  1.000 36.01244  ? 328 LYS A HG3  1 
ATOM   4529 H  HD2  . LYS A 1 328 ? 11.04700 -2.22000  7.79800  1.000 52.60460  ? 328 LYS A HD2  1 
ATOM   4530 H  HD3  . LYS A 1 328 ? 10.64000 -1.57300  6.40500  1.000 52.60460  ? 328 LYS A HD3  1 
ATOM   4531 H  HE2  . LYS A 1 328 ? 8.64800  -2.25600  6.94600  1.000 53.42644  ? 328 LYS A HE2  1 
ATOM   4532 H  HE3  . LYS A 1 328 ? 9.15700  -3.65000  6.37700  1.000 53.42644  ? 328 LYS A HE3  1 
ATOM   4533 H  HZ1  . LYS A 1 328 ? 9.60500  -4.30200  8.48900  1.000 64.27839  ? 328 LYS A HZ1  1 
ATOM   4534 H  HZ2  . LYS A 1 328 ? 9.24500  -3.00900  9.03500  1.000 64.27839  ? 328 LYS A HZ2  1 
ATOM   4535 H  HZ3  . LYS A 1 328 ? 8.22500  -3.86300  8.46200  1.000 64.27839  ? 328 LYS A HZ3  1 
ATOM   4536 N  N    . ALA A 1 329 ? 14.54500 -1.05400  3.28300  1.000 29.19877  ? 329 ALA A N    1 
ATOM   4537 C  CA   . ALA A 1 329 ? 15.51900 -0.03300  2.90900  1.000 35.00381  ? 329 ALA A CA   1 
ATOM   4538 C  C    . ALA A 1 329 ? 14.87000 1.07200   2.08400  1.000 33.05995  ? 329 ALA A C    1 
ATOM   4539 O  O    . ALA A 1 329 ? 15.15800 2.25800   2.28300  1.000 35.17047  ? 329 ALA A O    1 
ATOM   4540 C  CB   . ALA A 1 329 ? 16.67300 -0.66600  2.13200  1.000 33.40942  ? 329 ALA A CB   1 
ATOM   4541 H  H    . ALA A 1 329 ? 14.71500 -1.84000  2.98000  1.000 34.97829  ? 329 ALA A H    1 
ATOM   4542 H  HA   . ALA A 1 329 ? 15.87900 0.36200   3.71800  1.000 41.94433  ? 329 ALA A HA   1 
ATOM   4543 H  HB1  . ALA A 1 329 ? 17.30700 0.02700   1.88900  1.000 40.03107  ? 329 ALA A HB1  1 
ATOM   4544 H  HB2  . ALA A 1 329 ? 17.10600 -1.32800  2.69400  1.000 40.03107  ? 329 ALA A HB2  1 
ATOM   4545 H  HB3  . ALA A 1 329 ? 16.32200 -1.08900  1.33300  1.000 40.03107  ? 329 ALA A HB3  1 
ATOM   4546 N  N    . SER A 1 330 ? 13.99500 0.70300   1.15000  1.000 32.17439  ? 330 SER A N    1 
ATOM   4547 C  CA   . SER A 1 330 ? 13.32700 1.71500   0.33500  1.000 34.33845  ? 330 SER A CA   1 
ATOM   4548 C  C    . SER A 1 330 ? 12.32400 2.51600   1.15800  1.000 27.56262  ? 330 SER A C    1 
ATOM   4549 O  O    . SER A 1 330 ? 12.13400 3.71200   0.90800  1.000 29.88358  ? 330 SER A O    1 
ATOM   4550 C  CB   . SER A 1 330 ? 12.64400 1.05300   -0.86000 1.000 36.56229  ? 330 SER A CB   1 
ATOM   4551 O  OG   . SER A 1 330 ? 11.40700 0.46800   -0.48900 1.000 41.14398  ? 330 SER A OG   1 
ATOM   4552 H  H    . SER A 1 330 ? 13.77500 -0.10900  0.97000  1.000 38.54903  ? 330 SER A H    1 
ATOM   4553 H  HA   . SER A 1 330 ? 13.98800 2.33500   -0.01000 1.000 41.14591  ? 330 SER A HA   1 
ATOM   4554 H  HB2  . SER A 1 330 ? 12.48100 1.72500   -1.54100 1.000 43.81451  ? 330 SER A HB2  1 
ATOM   4555 H  HB3  . SER A 1 330 ? 13.22600 0.36000   -1.21000 1.000 43.81451  ? 330 SER A HB3  1 
ATOM   4556 H  HG   . SER A 1 330 ? 11.03700 0.12700   -1.16200 1.000 49.31253  ? 330 SER A HG   1 
ATOM   4557 N  N    . GLN A 1 331 ? 11.68900 1.88400   2.14500  1.000 26.44311  ? 331 GLN A N    1 
ATOM   4558 C  CA   . GLN A 1 331 ? 10.78500 2.61300   3.02700  1.000 32.38559  ? 331 GLN A CA   1 
ATOM   4559 C  C    . GLN A 1 331 ? 11.55800 3.53700   3.95900  1.000 29.80811  ? 331 GLN A C    1 
ATOM   4560 O  O    . GLN A 1 331 ? 11.09700 4.64100   4.27300  1.000 30.42733  ? 331 GLN A O    1 
ATOM   4561 C  CB   . GLN A 1 331 ? 9.93300  1.62800   3.82900  1.000 24.09359  ? 331 GLN A CB   1 
ATOM   4562 C  CG   . GLN A 1 331 ? 9.00900  0.77900   2.96400  1.000 30.17954  ? 331 GLN A CG   1 
ATOM   4563 C  CD   . GLN A 1 331 ? 8.18500  -0.19700  3.77500  1.000 36.56384  ? 331 GLN A CD   1 
ATOM   4564 O  OE1  . GLN A 1 331 ? 8.50900  -0.49500  4.92300  1.000 31.57122  ? 331 GLN A OE1  1 
ATOM   4565 N  NE2  . GLN A 1 331 ? 7.11500  -0.70700  3.17800  1.000 35.63028  ? 331 GLN A NE2  1 
ATOM   4566 H  H    . GLN A 1 331 ? 11.76300 1.04600   2.32100  1.000 31.67150  ? 331 GLN A H    1 
ATOM   4567 H  HA   . GLN A 1 331 ? 10.18800 3.15800   2.49100  1.000 38.80247  ? 331 GLN A HA   1 
ATOM   4568 H  HB2  . GLN A 1 331 ? 10.52100 1.02800   4.31300  1.000 28.85207  ? 331 GLN A HB2  1 
ATOM   4569 H  HB3  . GLN A 1 331 ? 9.38200  2.12700   4.45200  1.000 28.85207  ? 331 GLN A HB3  1 
ATOM   4570 H  HG2  . GLN A 1 331 ? 8.39900  1.36300   2.48600  1.000 36.15522  ? 331 GLN A HG2  1 
ATOM   4571 H  HG3  . GLN A 1 331 ? 9.54300  0.27100   2.33400  1.000 36.15522  ? 331 GLN A HG3  1 
ATOM   4572 H  HE21 . GLN A 1 331 ? 6.92200  -0.47800  2.37100  1.000 42.69610  ? 331 GLN A HE21 1 
ATOM   4573 H  HE22 . GLN A 1 331 ? 6.61400  -1.26600  3.59700  1.000 42.69610  ? 331 GLN A HE22 1 
ATOM   4574 N  N    . ALA A 1 332 ? 12.73900 3.10600   4.40600  1.000 32.68743  ? 332 ALA A N    1 
ATOM   4575 C  CA   . ALA A 1 332 ? 13.56200 3.95300   5.26200  1.000 30.67027  ? 332 ALA A CA   1 
ATOM   4576 C  C    . ALA A 1 332 ? 14.02900 5.19400   4.51200  1.000 36.21154  ? 332 ALA A C    1 
ATOM   4577 O  O    . ALA A 1 332 ? 13.93600 6.31600   5.02700  1.000 26.62171  ? 332 ALA A O    1 
ATOM   4578 C  CB   . ALA A 1 332 ? 14.75900 3.16000   5.78400  1.000 31.60452  ? 332 ALA A CB   1 
ATOM   4579 H  H    . ALA A 1 332 ? 13.08000 2.33600   4.23000  1.000 39.16468  ? 332 ALA A H    1 
ATOM   4580 H  HA   . ALA A 1 332 ? 13.03300 4.23800   6.02300  1.000 36.74408  ? 332 ALA A HA   1 
ATOM   4581 H  HB1  . ALA A 1 332 ? 15.32100 3.74800   6.31300  1.000 37.86519  ? 332 ALA A HB1  1 
ATOM   4582 H  HB2  . ALA A 1 332 ? 14.43800 2.42700   6.33200  1.000 37.86519  ? 332 ALA A HB2  1 
ATOM   4583 H  HB3  . ALA A 1 332 ? 15.26200 2.81300   5.03000  1.000 37.86519  ? 332 ALA A HB3  1 
ATOM   4584 N  N    . ARG A 1 333 ? 14.54200 5.01200   3.29300  1.000 26.12942  ? 333 ARG A N    1 
ATOM   4585 C  CA   . ARG A 1 333 ? 14.99500 6.16000   2.51500  1.000 31.49872  ? 333 ARG A CA   1 
ATOM   4586 C  C    . ARG A 1 333 ? 13.83300 7.08000   2.16800  1.000 36.51768  ? 333 ARG A C    1 
ATOM   4587 O  O    . ARG A 1 333 ? 14.00700 8.30400   2.10000  1.000 30.77211  ? 333 ARG A O    1 
ATOM   4588 C  CB   . ARG A 1 333 ? 15.71500 5.68900   1.24900  1.000 27.28905  ? 333 ARG A CB   1 
ATOM   4589 C  CG   . ARG A 1 333 ? 16.35400 6.81600   0.45000  1.000 39.65742  ? 333 ARG A CG   1 
ATOM   4590 C  CD   . ARG A 1 333 ? 16.97500 6.34600   -0.87000 1.000 48.43810  ? 333 ARG A CD   1 
ATOM   4591 N  NE   . ARG A 1 333 ? 17.90600 5.24000   -0.68200 1.000 44.17535  ? 333 ARG A NE   1 
ATOM   4592 C  CZ   . ARG A 1 333 ? 17.63600 3.96400   -0.93600 1.000 59.57542  ? 333 ARG A CZ   1 
ATOM   4593 N  NH1  . ARG A 1 333 ? 16.50300 3.59300   -1.51200 1.000 61.50804  ? 333 ARG A NH1  1 
ATOM   4594 N  NH2  . ARG A 1 333 ? 18.53500 3.03700   -0.61600 1.000 60.29524  ? 333 ARG A NH2  1 
ATOM   4595 H  H    . ARG A 1 333 ? 14.63700 4.25100   2.90400  1.000 31.29507  ? 333 ARG A H    1 
ATOM   4596 H  HA   . ARG A 1 333 ? 15.63300 6.66900   3.03900  1.000 37.73823  ? 333 ARG A HA   1 
ATOM   4597 H  HB2  . ARG A 1 333 ? 16.41800 5.07000   1.50200  1.000 32.68662  ? 333 ARG A HB2  1 
ATOM   4598 H  HB3  . ARG A 1 333 ? 15.07400 5.24400   0.67300  1.000 32.68662  ? 333 ARG A HB3  1 
ATOM   4599 H  HG2  . ARG A 1 333 ? 15.67600 7.47700   0.24100  1.000 47.52867  ? 333 ARG A HG2  1 
ATOM   4600 H  HG3  . ARG A 1 333 ? 17.05700 7.21900   0.98300  1.000 47.52867  ? 333 ARG A HG3  1 
ATOM   4601 H  HD2  . ARG A 1 333 ? 16.26900 6.04800   -1.46500 1.000 58.06548  ? 333 ARG A HD2  1 
ATOM   4602 H  HD3  . ARG A 1 333 ? 17.46000 7.08300   -1.27300 1.000 58.06548  ? 333 ARG A HD3  1 
ATOM   4603 H  HE   . ARG A 1 333 ? 18.69000 5.42800   -0.38300 1.000 52.95018  ? 333 ARG A HE   1 
ATOM   4604 H  HH11 . ARG A 1 333 ? 15.91800 4.18400   -1.73100 1.000 73.74941  ? 333 ARG A HH11 1 
ATOM   4605 H  HH12 . ARG A 1 333 ? 16.35200 2.76000   -1.66600 1.000 73.74941  ? 333 ARG A HH12 1 
ATOM   4606 H  HH21 . ARG A 1 333 ? 19.27900 3.26800   -0.25000 1.000 72.29405  ? 333 ARG A HH21 1 
ATOM   4607 H  HH22 . ARG A 1 333 ? 18.37300 2.20800   -0.77600 1.000 72.29405  ? 333 ARG A HH22 1 
ATOM   4608 N  N    . ASP A 1 334 ? 12.63900 6.51900   1.95900  1.000 32.43549  ? 334 ASP A N    1 
ATOM   4609 C  CA   . ASP A 1 334 ? 11.47400 7.35500   1.68900  1.000 32.95418  ? 334 ASP A CA   1 
ATOM   4610 C  C    . ASP A 1 334 ? 11.16000 8.25200   2.88100  1.000 28.24019  ? 334 ASP A C    1 
ATOM   4611 O  O    . ASP A 1 334 ? 10.96100 9.46300   2.72600  1.000 24.60275  ? 334 ASP A O    1 
ATOM   4612 C  CB   . ASP A 1 334 ? 10.26700 6.48500   1.34300  1.000 29.53263  ? 334 ASP A CB   1 
ATOM   4613 C  CG   . ASP A 1 334 ? 9.05000  7.30900   0.97100  1.000 42.45821  ? 334 ASP A CG   1 
ATOM   4614 O  OD1  . ASP A 1 334 ? 9.03900  7.88800   -0.13700 1.000 43.59144  ? 334 ASP A OD1  1 
ATOM   4615 O  OD2  . ASP A 1 334 ? 8.10900  7.38700   1.78800  1.000 37.64786  ? 334 ASP A OD2  1 
ATOM   4616 H  H    . ASP A 1 334 ? 12.48200 5.67300   1.96700  1.000 38.86235  ? 334 ASP A H    1 
ATOM   4617 H  HA   . ASP A 1 334 ? 11.66700 7.91800   0.92400  1.000 39.48477  ? 334 ASP A HA   1 
ATOM   4618 H  HB2  . ASP A 1 334 ? 10.49000 5.91900   0.58800  1.000 35.37892  ? 334 ASP A HB2  1 
ATOM   4619 H  HB3  . ASP A 1 334 ? 10.03800 5.94000   2.11200  1.000 35.37892  ? 334 ASP A HB3  1 
ATOM   4620 N  N    . LEU A 1 335 ? 11.10300 7.67100   4.08300  1.000 28.16937  ? 335 LEU A N    1 
ATOM   4621 C  CA   . LEU A 1 335 ? 10.84100 8.47000   5.27600  1.000 26.44791  ? 335 LEU A CA   1 
ATOM   4622 C  C    . LEU A 1 335 ? 11.91200 9.53900   5.45300  1.000 22.15442  ? 335 LEU A C    1 
ATOM   4623 O  O    . LEU A 1 335 ? 11.60100 10.71200  5.68900  1.000 28.23341  ? 335 LEU A O    1 
ATOM   4624 C  CB   . LEU A 1 335 ? 10.76700 7.57200   6.51400  1.000 29.65155  ? 335 LEU A CB   1 
ATOM   4625 C  CG   . LEU A 1 335 ? 10.47600 8.30100   7.83100  1.000 31.85670  ? 335 LEU A CG   1 
ATOM   4626 C  CD1  . LEU A 1 335 ? 9.23200  9.17100   7.70300  1.000 33.17651  ? 335 LEU A CD1  1 
ATOM   4627 C  CD2  . LEU A 1 335 ? 10.32600 7.32400   8.98900  1.000 25.19913  ? 335 LEU A CD2  1 
ATOM   4628 H  H    . LEU A 1 335 ? 11.21100 6.83100   4.23000  1.000 33.74301  ? 335 LEU A H    1 
ATOM   4629 H  HA   . LEU A 1 335 ? 9.98100  8.90800   5.17600  1.000 31.67725  ? 335 LEU A HA   1 
ATOM   4630 H  HB2  . LEU A 1 335 ? 10.06000 6.92300   6.37800  1.000 35.52162  ? 335 LEU A HB2  1 
ATOM   4631 H  HB3  . LEU A 1 335 ? 11.61900 7.12000   6.61400  1.000 35.52162  ? 335 LEU A HB3  1 
ATOM   4632 H  HG   . LEU A 1 335 ? 11.23100 8.87700   8.03000  1.000 38.16780  ? 335 LEU A HG   1 
ATOM   4633 H  HD11 . LEU A 1 335 ? 8.87200  9.33800   8.58800  1.000 39.75158  ? 335 LEU A HD11 1 
ATOM   4634 H  HD12 . LEU A 1 335 ? 9.47500  10.00900  7.28100  1.000 39.75158  ? 335 LEU A HD12 1 
ATOM   4635 H  HD13 . LEU A 1 335 ? 8.57600  8.70500   7.16200  1.000 39.75158  ? 335 LEU A HD13 1 
ATOM   4636 H  HD21 . LEU A 1 335 ? 10.10400 7.81800   9.79300  1.000 30.17871  ? 335 LEU A HD21 1 
ATOM   4637 H  HD22 . LEU A 1 335 ? 9.61800  6.69400   8.78100  1.000 30.17871  ? 335 LEU A HD22 1 
ATOM   4638 H  HD23 . LEU A 1 335 ? 11.16400 6.85000   9.11300  1.000 30.17871  ? 335 LEU A HD23 1 
ATOM   4639 N  N    . LEU A 1 336 ? 13.18400 9.14800   5.34200  1.000 23.83729  ? 336 LEU A N    1 
ATOM   4640 C  CA   . LEU A 1 336 ? 14.27400 10.11500  5.40800  1.000 26.00423  ? 336 LEU A CA   1 
ATOM   4641 C  C    . LEU A 1 336 ? 14.01500 11.29300  4.48000  1.000 34.16858  ? 336 LEU A C    1 
ATOM   4642 O  O    . LEU A 1 336 ? 14.12200 12.45600  4.88400  1.000 30.27309  ? 336 LEU A O    1 
ATOM   4643 C  CB   . LEU A 1 336 ? 15.59600 9.44200   5.03800  1.000 29.38966  ? 336 LEU A CB   1 
ATOM   4644 C  CG   . LEU A 1 336 ? 16.40700 8.80600   6.16300  1.000 34.53062  ? 336 LEU A CG   1 
ATOM   4645 C  CD1  . LEU A 1 336 ? 17.54500 7.98000   5.58000  1.000 34.58314  ? 336 LEU A CD1  1 
ATOM   4646 C  CD2  . LEU A 1 336 ? 16.93800 9.87700   7.10700  1.000 32.01809  ? 336 LEU A CD2  1 
ATOM   4647 H  H    . LEU A 1 336 ? 13.43800 8.33500   5.22900  1.000 28.54450  ? 336 LEU A H    1 
ATOM   4648 H  HA   . LEU A 1 336 ? 14.34100 10.44300  6.31800  1.000 31.14484  ? 336 LEU A HA   1 
ATOM   4649 H  HB2  . LEU A 1 336 ? 15.40200 8.73800   4.40000  1.000 35.20735  ? 336 LEU A HB2  1 
ATOM   4650 H  HB3  . LEU A 1 336 ? 16.16500 10.11300  4.62900  1.000 35.20735  ? 336 LEU A HB3  1 
ATOM   4651 H  HG   . LEU A 1 336 ? 15.83800 8.21400   6.67900  1.000 41.37650  ? 336 LEU A HG   1 
ATOM   4652 H  HD11 . LEU A 1 336 ? 17.99200 7.50600   6.29900  1.000 41.43953  ? 336 LEU A HD11 1 
ATOM   4653 H  HD12 . LEU A 1 336 ? 17.18100 7.34600   4.94200  1.000 41.43953  ? 336 LEU A HD12 1 
ATOM   4654 H  HD13 . LEU A 1 336 ? 18.17100 8.57300   5.13600  1.000 41.43953  ? 336 LEU A HD13 1 
ATOM   4655 H  HD21 . LEU A 1 336 ? 17.62600 9.48900   7.66900  1.000 38.36146  ? 336 LEU A HD21 1 
ATOM   4656 H  HD22 . LEU A 1 336 ? 17.30900 10.60300  6.58300  1.000 38.36146  ? 336 LEU A HD22 1 
ATOM   4657 H  HD23 . LEU A 1 336 ? 16.20800 10.20400  7.65500  1.000 38.36146  ? 336 LEU A HD23 1 
ATOM   4658 N  N    . SER A 1 337 ? 13.67200 11.00500  3.22200  1.000 27.72654  ? 337 SER A N    1 
ATOM   4659 C  CA   . SER A 1 337 ? 13.47400 12.06900  2.24800  1.000 28.76218  ? 337 SER A CA   1 
ATOM   4660 C  C    . SER A 1 337 ? 12.29800 12.96900  2.60300  1.000 27.94155  ? 337 SER A C    1 
ATOM   4661 O  O    . SER A 1 337 ? 12.19900 14.07600  2.06300  1.000 31.57547  ? 337 SER A O    1 
ATOM   4662 C  CB   . SER A 1 337 ? 13.27900 11.46800  0.85000  1.000 30.40429  ? 337 SER A CB   1 
ATOM   4663 O  OG   . SER A 1 337 ? 11.94800 11.02800  0.65800  1.000 28.69761  ? 337 SER A OG   1 
ATOM   4664 H  H    . SER A 1 337 ? 13.54900 10.21100  2.91500  1.000 33.21161  ? 337 SER A H    1 
ATOM   4665 H  HA   . SER A 1 337 ? 14.27000 12.62300  2.22600  1.000 34.45438  ? 337 SER A HA   1 
ATOM   4666 H  HB2  . SER A 1 337 ? 13.48400 12.14500  0.18600  1.000 36.42491  ? 337 SER A HB2  1 
ATOM   4667 H  HB3  . SER A 1 337 ? 13.87800 10.71100  0.74800  1.000 36.42491  ? 337 SER A HB3  1 
ATOM   4668 H  HG   . SER A 1 337 ? 11.75300 10.44500  1.23000  1.000 34.37690  ? 337 SER A HG   1 
ATOM   4669 N  N    . LYS A 1 338 ? 11.41300 12.53400  3.50200  1.000 25.49904  ? 338 LYS A N    1 
ATOM   4670 C  CA   . LYS A 1 338 ? 10.28100 13.36200  3.89800  1.000 29.92590  ? 338 LYS A CA   1 
ATOM   4671 C  C    . LYS A 1 338 ? 10.50700 14.13300  5.19600  1.000 33.20761  ? 338 LYS A C    1 
ATOM   4672 O  O    . LYS A 1 338 ? 9.78700  15.10600  5.44000  1.000 25.34482  ? 338 LYS A O    1 
ATOM   4673 C  CB   . LYS A 1 338 ? 9.01300  12.51000  4.04200  1.000 28.81741  ? 338 LYS A CB   1 
ATOM   4674 C  CG   . LYS A 1 338 ? 8.55500  11.84800  2.74800  1.000 27.26217  ? 338 LYS A CG   1 
ATOM   4675 C  CD   . LYS A 1 338 ? 7.45200  10.82800  3.01500  1.000 38.21634  ? 338 LYS A CD   1 
ATOM   4676 C  CE   . LYS A 1 338 ? 6.48800  10.71500  1.84600  1.000 48.91535  ? 338 LYS A CE   1 
ATOM   4677 N  NZ   . LYS A 1 338 ? 7.18800  10.66900  0.53400  1.000 54.80329  ? 338 LYS A NZ   1 
ATOM   4678 H  H    . LYS A 1 338 ? 11.44900 11.76900  3.89100  1.000 30.53861  ? 338 LYS A H    1 
ATOM   4679 H  HA   . LYS A 1 338 ? 10.12400 14.01100  3.19400  1.000 35.85084  ? 338 LYS A HA   1 
ATOM   4680 H  HB2  . LYS A 1 338 ? 9.18400  11.80700  4.68800  1.000 34.52065  ? 338 LYS A HB2  1 
ATOM   4681 H  HB3  . LYS A 1 338 ? 8.29200  13.07900  4.35300  1.000 34.52065  ? 338 LYS A HB3  1 
ATOM   4682 H  HG2  . LYS A 1 338 ? 8.20800  12.52300  2.14400  1.000 32.65437  ? 338 LYS A HG2  1 
ATOM   4683 H  HG3  . LYS A 1 338 ? 9.30400  11.38800  2.33700  1.000 32.65437  ? 338 LYS A HG3  1 
ATOM   4684 H  HD2  . LYS A 1 338 ? 7.85200  9.95700   3.16400  1.000 45.79937  ? 338 LYS A HD2  1 
ATOM   4685 H  HD3  . LYS A 1 338 ? 6.94900  11.10000  3.79800  1.000 45.79937  ? 338 LYS A HD3  1 
ATOM   4686 H  HE2  . LYS A 1 338 ? 5.96900  9.90000   1.94000  1.000 58.63818  ? 338 LYS A HE2  1 
ATOM   4687 H  HE3  . LYS A 1 338 ? 5.89800  11.48500  1.84500  1.000 58.63818  ? 338 LYS A HE3  1 
ATOM   4688 H  HZ1  . LYS A 1 338 ? 6.59600  10.57400  -0.12400 1.000 65.70370  ? 338 LYS A HZ1  1 
ATOM   4689 H  HZ2  . LYS A 1 338 ? 7.64500  11.42200  0.40600  1.000 65.70370  ? 338 LYS A HZ2  1 
ATOM   4690 H  HZ3  . LYS A 1 338 ? 7.75300  9.98100   0.51500  1.000 65.70370  ? 338 LYS A HZ3  1 
ATOM   4691 N  N    . MET A 1 339 ? 11.47400 13.73900  6.03100  1.000 23.89370  ? 339 MET A N    1 
ATOM   4692 C  CA   . MET A 1 339 ? 11.76500 14.52800  7.22400  1.000 25.11296  ? 339 MET A CA   1 
ATOM   4693 C  C    . MET A 1 339 ? 13.04600 15.35400  7.11400  1.000 26.54038  ? 339 MET A C    1 
ATOM   4694 O  O    . MET A 1 339 ? 13.17200 16.34800  7.83600  1.000 28.20763  ? 339 MET A O    1 
ATOM   4695 C  CB   . MET A 1 339 ? 11.81900 13.63700  8.48200  1.000 31.54605  ? 339 MET A CB   1 
ATOM   4696 C  CG   . MET A 1 339 ? 12.33700 12.22800  8.33300  1.000 25.36246  ? 339 MET A CG   1 
ATOM   4697 S  SD   . MET A 1 339 ? 12.39600 11.32500  9.91500  1.000 39.67633  ? 339 MET A SD   1 
ATOM   4698 C  CE   . MET A 1 339 ? 10.68300 11.36400  10.43400 1.000 23.55236  ? 339 MET A CE   1 
ATOM   4699 H  H    . MET A 1 339 ? 11.96000 13.03600  5.92900  1.000 28.61220  ? 339 MET A H    1 
ATOM   4700 H  HA   . MET A 1 339 ? 11.02800 15.14400  7.36000  1.000 30.07532  ? 339 MET A HA   1 
ATOM   4701 H  HB2  . MET A 1 339 ? 12.39200 14.07600  9.13000  1.000 37.79503  ? 339 MET A HB2  1 
ATOM   4702 H  HB3  . MET A 1 339 ? 10.91700 13.56600  8.83200  1.000 37.79503  ? 339 MET A HB3  1 
ATOM   4703 H  HG2  . MET A 1 339 ? 11.75400 11.74000  7.73100  1.000 30.37471  ? 339 MET A HG2  1 
ATOM   4704 H  HG3  . MET A 1 339 ? 13.23700 12.25900  7.97200  1.000 30.37471  ? 339 MET A HG3  1 
ATOM   4705 H  HE1  . MET A 1 339 ? 10.52600 10.64100  11.06100 1.000 28.20259  ? 339 MET A HE1  1 
ATOM   4706 H  HE2  . MET A 1 339 ? 10.50200 12.21600  10.86000 1.000 28.20259  ? 339 MET A HE2  1 
ATOM   4707 H  HE3  . MET A 1 339 ? 10.11500 11.25600  9.65500  1.000 28.20259  ? 339 MET A HE3  1 
ATOM   4708 N  N    . LEU A 1 340 ? 13.97100 15.01300  6.21600  1.000 24.31555  ? 340 LEU A N    1 
ATOM   4709 C  CA   . LEU A 1 340 ? 15.11100 15.89200  5.93900  1.000 24.92987  ? 340 LEU A CA   1 
ATOM   4710 C  C    . LEU A 1 340 ? 14.74200 16.83300  4.78800  1.000 29.59443  ? 340 LEU A C    1 
ATOM   4711 O  O    . LEU A 1 340 ? 15.26500 16.76500  3.67300  1.000 24.24492  ? 340 LEU A O    1 
ATOM   4712 C  CB   . LEU A 1 340 ? 16.36400 15.08500  5.63100  1.000 23.84707  ? 340 LEU A CB   1 
ATOM   4713 C  CG   . LEU A 1 340 ? 17.00600 14.35400  6.81300  1.000 29.21184  ? 340 LEU A CG   1 
ATOM   4714 C  CD1  . LEU A 1 340 ? 18.16500 13.50200  6.32900  1.000 29.47303  ? 340 LEU A CD1  1 
ATOM   4715 C  CD2  . LEU A 1 340 ? 17.46900 15.33400  7.89000  1.000 24.72544  ? 340 LEU A CD2  1 
ATOM   4716 H  H    . LEU A 1 340 ? 13.96200 14.28500  5.75800  1.000 29.11842  ? 340 LEU A H    1 
ATOM   4717 H  HA   . LEU A 1 340 ? 15.29700 16.42400  6.72900  1.000 29.85561  ? 340 LEU A HA   1 
ATOM   4718 H  HB2  . LEU A 1 340 ? 16.13500 14.41300  4.96900  1.000 28.55625  ? 340 LEU A HB2  1 
ATOM   4719 H  HB3  . LEU A 1 340 ? 17.03200 15.69000  5.27200  1.000 28.55625  ? 340 LEU A HB3  1 
ATOM   4720 H  HG   . LEU A 1 340 ? 16.34400 13.77400  7.21900  1.000 34.99397  ? 340 LEU A HG   1 
ATOM   4721 H  HD11 . LEU A 1 340 ? 18.53800 13.01900  7.08200  1.000 35.30740  ? 340 LEU A HD11 1 
ATOM   4722 H  HD12 . LEU A 1 340 ? 17.84000 12.87600  5.66300  1.000 35.30740  ? 340 LEU A HD12 1 
ATOM   4723 H  HD13 . LEU A 1 340 ? 18.84000 14.07900  5.93800  1.000 35.30740  ? 340 LEU A HD13 1 
ATOM   4724 H  HD21 . LEU A 1 340 ? 18.08300 14.87900  8.48800  1.000 29.61028  ? 340 LEU A HD21 1 
ATOM   4725 H  HD22 . LEU A 1 340 ? 17.91600 16.08300  7.46500  1.000 29.61028  ? 340 LEU A HD22 1 
ATOM   4726 H  HD23 . LEU A 1 340 ? 16.69600 15.64800  8.38500  1.000 29.61028  ? 340 LEU A HD23 1 
ATOM   4727 N  N    . VAL A 1 341 ? 13.81100 17.72900  5.09900  1.000 28.28253  ? 341 VAL A N    1 
ATOM   4728 C  CA   . VAL A 1 341 ? 13.25500 18.68200  4.14700  1.000 30.12705  ? 341 VAL A CA   1 
ATOM   4729 C  C    . VAL A 1 341 ? 13.42900 20.06800  4.75100  1.000 28.83969  ? 341 VAL A C    1 
ATOM   4730 O  O    . VAL A 1 341 ? 12.94200 20.32800  5.85700  1.000 24.55922  ? 341 VAL A O    1 
ATOM   4731 C  CB   . VAL A 1 341 ? 11.77500 18.38900  3.85300  1.000 31.32799  ? 341 VAL A CB   1 
ATOM   4732 C  CG1  . VAL A 1 341 ? 11.20400 19.39800  2.87200  1.000 33.46930  ? 341 VAL A CG1  1 
ATOM   4733 C  CG2  . VAL A 1 341 ? 11.61300 16.96300  3.32000  1.000 31.43007  ? 341 VAL A CG2  1 
ATOM   4734 H  H    . VAL A 1 341 ? 13.47200 17.80600  5.88500  1.000 33.87880  ? 341 VAL A H    1 
ATOM   4735 H  HA   . VAL A 1 341 ? 13.74200 18.64700  3.30800  1.000 36.09223  ? 341 VAL A HA   1 
ATOM   4736 H  HB   . VAL A 1 341 ? 11.27200 18.46600  4.67900  1.000 37.53335  ? 341 VAL A HB   1 
ATOM   4737 H  HG11 . VAL A 1 341 ? 10.29500 19.14200  2.64900  1.000 40.10292  ? 341 VAL A HG11 1 
ATOM   4738 H  HG12 . VAL A 1 341 ? 11.20900 20.27600  3.28400  1.000 40.10292  ? 341 VAL A HG12 1 
ATOM   4739 H  HG13 . VAL A 1 341 ? 11.75100 19.40500  2.07200  1.000 40.10292  ? 341 VAL A HG13 1 
ATOM   4740 H  HG21 . VAL A 1 341 ? 10.68200 16.81600  3.09000  1.000 37.65584  ? 341 VAL A HG21 1 
ATOM   4741 H  HG22 . VAL A 1 341 ? 12.16900 16.85500  2.53200  1.000 37.65584  ? 341 VAL A HG22 1 
ATOM   4742 H  HG23 . VAL A 1 341 ? 11.88700 16.33600  4.00700  1.000 37.65584  ? 341 VAL A HG23 1 
ATOM   4743 N  N    . ILE A 1 342 ? 14.12500 20.95400  4.03200  1.000 26.88249  ? 342 ILE A N    1 
ATOM   4744 C  CA   . ILE A 1 342 ? 14.48600 22.25000  4.60600  1.000 31.62790  ? 342 ILE A CA   1 
ATOM   4745 C  C    . ILE A 1 342 ? 13.23500 23.05100  4.94400  1.000 32.24965  ? 342 ILE A C    1 
ATOM   4746 O  O    . ILE A 1 342 ? 13.09300 23.57700  6.05400  1.000 29.59151  ? 342 ILE A O    1 
ATOM   4747 C  CB   . ILE A 1 342 ? 15.41200 23.02500  3.65000  1.000 23.52863  ? 342 ILE A CB   1 
ATOM   4748 C  CG1  . ILE A 1 342 ? 16.73700 22.27400  3.48500  1.000 29.34110  ? 342 ILE A CG1  1 
ATOM   4749 C  CG2  . ILE A 1 342 ? 15.64900 24.45100  4.17200  1.000 31.28025  ? 342 ILE A CG2  1 
ATOM   4750 C  CD1  . ILE A 1 342 ? 17.77800 23.00700  2.65600  1.000 32.82987  ? 342 ILE A CD1  1 
ATOM   4751 H  H    . ILE A 1 342 ? 14.39500 20.83100  3.22500  1.000 32.19874  ? 342 ILE A H    1 
ATOM   4752 H  HA   . ILE A 1 342 ? 14.97200 22.09400  5.43100  1.000 37.89324  ? 342 ILE A HA   1 
ATOM   4753 H  HB   . ILE A 1 342 ? 14.98500 23.09000  2.78100  1.000 28.17411  ? 342 ILE A HB   1 
ATOM   4754 H  HG12 . ILE A 1 342 ? 17.11700 22.12200  4.36400  1.000 35.14909  ? 342 ILE A HG12 1 
ATOM   4755 H  HG13 . ILE A 1 342 ? 16.55900 21.42600  3.04900  1.000 35.14909  ? 342 ILE A HG13 1 
ATOM   4756 H  HG21 . ILE A 1 342 ? 16.31100 24.88700  3.61300  1.000 37.47606  ? 342 ILE A HG21 1 
ATOM   4757 H  HG22 . ILE A 1 342 ? 14.81300 24.94300  4.13800  1.000 37.47606  ? 342 ILE A HG22 1 
ATOM   4758 H  HG23 . ILE A 1 342 ? 15.96700 24.40400  5.08700  1.000 37.47606  ? 342 ILE A HG23 1 
ATOM   4759 H  HD11 . ILE A 1 342 ? 18.46000 22.37700  2.37800  1.000 39.33560  ? 342 ILE A HD11 1 
ATOM   4760 H  HD12 . ILE A 1 342 ? 17.34700 23.39300  1.87800  1.000 39.33560  ? 342 ILE A HD12 1 
ATOM   4761 H  HD13 . ILE A 1 342 ? 18.17500 23.70800  3.19600  1.000 39.33560  ? 342 ILE A HD13 1 
ATOM   4762 N  N    . ASP A 1 343 ? 12.31100 23.15000  3.99700  1.000 27.26680  ? 343 ASP A N    1 
ATOM   4763 C  CA   . ASP A 1 343 ? 11.12800 23.98600  4.17100  1.000 38.71400  ? 343 ASP A CA   1 
ATOM   4764 C  C    . ASP A 1 343 ? 10.11500 23.27200  5.05700  1.000 30.37822  ? 343 ASP A C    1 
ATOM   4765 O  O    . ASP A 1 343 ? 9.61600  22.21000  4.67300  1.000 37.48048  ? 343 ASP A O    1 
ATOM   4766 C  CB   . ASP A 1 343 ? 10.51000 24.30700  2.81200  1.000 35.40221  ? 343 ASP A CB   1 
ATOM   4767 C  CG   . ASP A 1 343 ? 9.34800  25.27600  2.90900  1.000 43.51568  ? 343 ASP A CG   1 
ATOM   4768 O  OD1  . ASP A 1 343 ? 8.97200  25.65700  4.03700  1.000 43.14760  ? 343 ASP A OD1  1 
ATOM   4769 O  OD2  . ASP A 1 343 ? 8.80900  25.66300  1.84900  1.000 57.64495  ? 343 ASP A OD2  1 
ATOM   4770 H  H    . ASP A 1 343 ? 12.34400 22.74200  3.24100  1.000 32.65992  ? 343 ASP A H    1 
ATOM   4771 H  HA   . ASP A 1 343 ? 11.37300 24.82000  4.60300  1.000 46.39656  ? 343 ASP A HA   1 
ATOM   4772 H  HB2  . ASP A 1 343 ? 11.18700 24.70700  2.24400  1.000 42.42241  ? 343 ASP A HB2  1 
ATOM   4773 H  HB3  . ASP A 1 343 ? 10.18400 23.48600  2.41100  1.000 42.42241  ? 343 ASP A HB3  1 
ATOM   4774 N  N    . PRO A 1 344 ? 9.77400  23.81400  6.23200  1.000 27.12472  ? 344 PRO A N    1 
ATOM   4775 C  CA   . PRO A 1 344 ? 8.82000  23.10900  7.10500  1.000 33.54757  ? 344 PRO A CA   1 
ATOM   4776 C  C    . PRO A 1 344 ? 7.43400  22.96700  6.50300  1.000 35.80826  ? 344 PRO A C    1 
ATOM   4777 O  O    . PRO A 1 344 ? 6.68700  22.07100  6.91700  1.000 35.69167  ? 344 PRO A O    1 
ATOM   4778 C  CB   . PRO A 1 344 ? 8.79500  23.96800  8.37900  1.000 32.14172  ? 344 PRO A CB   1 
ATOM   4779 C  CG   . PRO A 1 344 ? 9.26100  25.31200  7.95500  1.000 31.59022  ? 344 PRO A CG   1 
ATOM   4780 C  CD   . PRO A 1 344 ? 10.20400 25.10300  6.80600  1.000 35.70315  ? 344 PRO A CD   1 
ATOM   4781 H  HA   . PRO A 1 344 ? 9.16400  22.22900  7.32500  1.000 40.19684  ? 344 PRO A HA   1 
ATOM   4782 H  HB2  . PRO A 1 344 ? 7.89200  24.00900  8.73000  1.000 38.50982  ? 344 PRO A HB2  1 
ATOM   4783 H  HB3  . PRO A 1 344 ? 9.39200  23.58800  9.04300  1.000 38.50982  ? 344 PRO A HB3  1 
ATOM   4784 H  HG2  . PRO A 1 344 ? 8.50000  25.84500  7.67700  1.000 37.84802  ? 344 PRO A HG2  1 
ATOM   4785 H  HG3  . PRO A 1 344 ? 9.71600  25.74500  8.69400  1.000 37.84802  ? 344 PRO A HG3  1 
ATOM   4786 H  HD2  . PRO A 1 344 ? 10.11600 25.81600  6.15400  1.000 42.78354  ? 344 PRO A HD2  1 
ATOM   4787 H  HD3  . PRO A 1 344 ? 11.12100 25.05000  7.11900  1.000 42.78354  ? 344 PRO A HD3  1 
ATOM   4788 N  N    . ALA A 1 345 ? 7.06200  23.81500  5.54300  1.000 35.02725  ? 345 ALA A N    1 
ATOM   4789 C  CA   . ALA A 1 345 ? 5.77500  23.64700  4.87900  1.000 38.72195  ? 345 ALA A CA   1 
ATOM   4790 C  C    . ALA A 1 345 ? 5.73200  22.35900  4.06600  1.000 35.60339  ? 345 ALA A C    1 
ATOM   4791 O  O    . ALA A 1 345 ? 4.65000  21.80800  3.83800  1.000 43.36889  ? 345 ALA A O    1 
ATOM   4792 C  CB   . ALA A 1 345 ? 5.48500  24.84900  3.98000  1.000 43.13333  ? 345 ALA A CB   1 
ATOM   4793 H  H    . ALA A 1 345 ? 7.52800  24.48200  5.26500  1.000 41.97246  ? 345 ALA A H    1 
ATOM   4794 H  HA   . ALA A 1 345 ? 5.07900  23.60300  5.55300  1.000 46.40611  ? 345 ALA A HA   1 
ATOM   4795 H  HB1  . ALA A 1 345 ? 4.62100  24.72500  3.55600  1.000 51.69976  ? 345 ALA A HB1  1 
ATOM   4796 H  HB2  . ALA A 1 345 ? 5.47500  25.65300  4.52200  1.000 51.69976  ? 345 ALA A HB2  1 
ATOM   4797 H  HB3  . ALA A 1 345 ? 6.17800  24.91300  3.30500  1.000 51.69976  ? 345 ALA A HB3  1 
ATOM   4798 N  N    . LYS A 1 346 ? 6.89200  21.86500  3.62900  1.000 31.78059  ? 346 LYS A N    1 
ATOM   4799 C  CA   . LYS A 1 346 ? 6.98600  20.64800  2.83300  1.000 33.71435  ? 346 LYS A CA   1 
ATOM   4800 C  C    . LYS A 1 346 ? 7.42600  19.44000  3.65200  1.000 32.52381  ? 346 LYS A C    1 
ATOM   4801 O  O    . LYS A 1 346 ? 7.41600  18.32100  3.13200  1.000 30.83400  ? 346 LYS A O    1 
ATOM   4802 C  CB   . LYS A 1 346 ? 7.96800  20.85700  1.67100  1.000 36.61903  ? 346 LYS A CB   1 
ATOM   4803 C  CG   . LYS A 1 346 ? 7.44300  21.76600  0.55800  1.000 41.86827  ? 346 LYS A CG   1 
ATOM   4804 C  CD   . LYS A 1 346 ? 8.54600  22.65800  -0.00600 1.000 51.18372  ? 346 LYS A CD   1 
ATOM   4805 C  CE   . LYS A 1 346 ? 8.16900  23.23500  -1.36700 1.000 72.90249  ? 346 LYS A CE   1 
ATOM   4806 N  NZ   . LYS A 1 346 ? 9.35300  23.74500  -2.12000 1.000 76.08261  ? 346 LYS A NZ   1 
ATOM   4807 H  H    . LYS A 1 346 ? 7.65600  22.22800  3.78600  1.000 38.07647  ? 346 LYS A H    1 
ATOM   4808 H  HA   . LYS A 1 346 ? 6.11400  20.45100  2.45600  1.000 40.39698  ? 346 LYS A HA   1 
ATOM   4809 H  HB2  . LYS A 1 346 ? 8.77900  21.25800  2.02000  1.000 43.88260  ? 346 LYS A HB2  1 
ATOM   4810 H  HB3  . LYS A 1 346 ? 8.16700  19.99400  1.27600  1.000 43.88260  ? 346 LYS A HB3  1 
ATOM   4811 H  HG2  . LYS A 1 346 ? 7.09300  21.22100  -0.16400 1.000 50.18169  ? 346 LYS A HG2  1 
ATOM   4812 H  HG3  . LYS A 1 346 ? 6.74200  22.33600  0.91300  1.000 50.18169  ? 346 LYS A HG3  1 
ATOM   4813 H  HD2  . LYS A 1 346 ? 8.70400  23.39600  0.60400  1.000 61.36023  ? 346 LYS A HD2  1 
ATOM   4814 H  HD3  . LYS A 1 346 ? 9.35700  22.13600  -0.11100 1.000 61.36023  ? 346 LYS A HD3  1 
ATOM   4815 H  HE2  . LYS A 1 346 ? 7.75000  22.54200  -1.90100 1.000 87.42275  ? 346 LYS A HE2  1 
ATOM   4816 H  HE3  . LYS A 1 346 ? 7.55300  23.97400  -1.23900 1.000 87.42275  ? 346 LYS A HE3  1 
ATOM   4817 H  HZ1  . LYS A 1 346 ? 9.09500  24.07100  -2.90800 1.000 91.23890  ? 346 LYS A HZ1  1 
ATOM   4818 H  HZ2  . LYS A 1 346 ? 9.75300  24.39200  -1.65700 1.000 91.23890  ? 346 LYS A HZ2  1 
ATOM   4819 H  HZ3  . LYS A 1 346 ? 9.93400  23.08600  -2.25700 1.000 91.23890  ? 346 LYS A HZ3  1 
ATOM   4820 N  N    . ARG A 1 347 ? 7.80600  19.64000  4.90800  1.000 30.08414  ? 347 ARG A N    1 
ATOM   4821 C  CA   . ARG A 1 347 ? 8.31700  18.56400  5.74400  1.000 23.58988  ? 347 ARG A CA   1 
ATOM   4822 C  C    . ARG A 1 347 ? 7.16600  17.79700  6.38400  1.000 28.22294  ? 347 ARG A C    1 
ATOM   4823 O  O    . ARG A 1 347 ? 6.12300  18.36200  6.72000  1.000 29.66452  ? 347 ARG A O    1 
ATOM   4824 C  CB   . ARG A 1 347 ? 9.24300  19.14000  6.81500  1.000 32.62693  ? 347 ARG A CB   1 
ATOM   4825 C  CG   . ARG A 1 347 ? 10.01200 18.11400  7.63400  1.000 28.94562  ? 347 ARG A CG   1 
ATOM   4826 C  CD   . ARG A 1 347 ? 10.74500 18.80100  8.78300  1.000 27.64087  ? 347 ARG A CD   1 
ATOM   4827 N  NE   . ARG A 1 347 ? 11.48500 19.96900  8.31800  1.000 25.64289  ? 347 ARG A NE   1 
ATOM   4828 C  CZ   . ARG A 1 347 ? 11.68800 21.07300  9.02500  1.000 33.33726  ? 347 ARG A CZ   1 
ATOM   4829 N  NH1  . ARG A 1 347 ? 11.23100 21.20200  10.26200 1.000 27.07990  ? 347 ARG A NH1  1 
ATOM   4830 N  NH2  . ARG A 1 347 ? 12.36700 22.07800  8.47700  1.000 29.20197  ? 347 ARG A NH2  1 
ATOM   4831 H  H    . ARG A 1 347 ? 7.77800  20.40200  5.30500  1.000 36.04073  ? 347 ARG A H    1 
ATOM   4832 H  HA   . ARG A 1 347 ? 8.82700  17.93500  5.21100  1.000 28.24762  ? 347 ARG A HA   1 
ATOM   4833 H  HB2  . ARG A 1 347 ? 9.89500  19.71100  6.38000  1.000 39.09208  ? 347 ARG A HB2  1 
ATOM   4834 H  HB3  . ARG A 1 347 ? 8.70700  19.66100  7.43400  1.000 39.09208  ? 347 ARG A HB3  1 
ATOM   4835 H  HG2  . ARG A 1 347 ? 9.39600  17.46300  8.00400  1.000 34.67450  ? 347 ARG A HG2  1 
ATOM   4836 H  HG3  . ARG A 1 347 ? 10.66500 17.67000  7.07000  1.000 34.67450  ? 347 ARG A HG3  1 
ATOM   4837 H  HD2  . ARG A 1 347 ? 10.10100 19.09100  9.44700  1.000 33.10880  ? 347 ARG A HD2  1 
ATOM   4838 H  HD3  . ARG A 1 347 ? 11.37400 18.17800  9.18000  1.000 33.10880  ? 347 ARG A HD3  1 
ATOM   4839 H  HE   . ARG A 1 347 ? 11.81400 19.94000  7.52400  1.000 30.71123  ? 347 ARG A HE   1 
ATOM   4840 H  HH11 . ARG A 1 347 ? 10.78900 20.55900  10.62500 1.000 32.43564  ? 347 ARG A HH11 1 
ATOM   4841 H  HH12 . ARG A 1 347 ? 11.37500 21.92700  10.70000 1.000 32.43564  ? 347 ARG A HH12 1 
ATOM   4842 H  HH21 . ARG A 1 347 ? 12.66800 22.00600  7.67500  1.000 34.98212  ? 347 ARG A HH21 1 
ATOM   4843 H  HH22 . ARG A 1 347 ? 12.50600 22.79800  8.92500  1.000 34.98212  ? 347 ARG A HH22 1 
ATOM   4844 N  N    . ILE A 1 348 ? 7.36500  16.48800  6.54800  1.000 34.85188  ? 348 ILE A N    1 
ATOM   4845 C  CA   . ILE A 1 348 ? 6.29100  15.63000  7.03300  1.000 27.01485  ? 348 ILE A CA   1 
ATOM   4846 C  C    . ILE A 1 348 ? 5.99900  15.94200  8.49800  1.000 29.53384  ? 348 ILE A C    1 
ATOM   4847 O  O    . ILE A 1 348 ? 6.88200  16.35900  9.26200  1.000 35.41610  ? 348 ILE A O    1 
ATOM   4848 C  CB   . ILE A 1 348 ? 6.65200  14.14600  6.83100  1.000 28.84891  ? 348 ILE A CB   1 
ATOM   4849 C  CG1  . ILE A 1 348 ? 5.48500  13.24800  7.24100  1.000 36.31116  ? 348 ILE A CG1  1 
ATOM   4850 C  CG2  . ILE A 1 348 ? 7.89800  13.77200  7.62600  1.000 26.23578  ? 348 ILE A CG2  1 
ATOM   4851 C  CD1  . ILE A 1 348 ? 5.63500  11.80200  6.78600  1.000 40.22347  ? 348 ILE A CD1  1 
ATOM   4852 H  H    . ILE A 1 348 ? 8.10400  16.07900  6.38700  1.000 41.76202  ? 348 ILE A H    1 
ATOM   4853 H  HA   . ILE A 1 348 ? 5.48600  15.81300  6.52300  1.000 32.35758  ? 348 ILE A HA   1 
ATOM   4854 H  HB   . ILE A 1 348 ? 6.83600  14.01600  5.88700  1.000 34.55846  ? 348 ILE A HB   1 
ATOM   4855 H  HG12 . ILE A 1 348 ? 5.41600  13.24800  8.20900  1.000 43.51315  ? 348 ILE A HG12 1 
ATOM   4856 H  HG13 . ILE A 1 348 ? 4.66900  13.59800  6.85100  1.000 43.51315  ? 348 ILE A HG13 1 
ATOM   4857 H  HG21 . ILE A 1 348 ? 8.19700  12.89200  7.34900  1.000 31.42269  ? 348 ILE A HG21 1 
ATOM   4858 H  HG22 . ILE A 1 348 ? 8.59200  14.42700  7.45200  1.000 31.42269  ? 348 ILE A HG22 1 
ATOM   4859 H  HG23 . ILE A 1 348 ? 7.67900  13.76500  8.57100  1.000 31.42269  ? 348 ILE A HG23 1 
ATOM   4860 H  HD11 . ILE A 1 348 ? 4.83000  11.31300  7.01600  1.000 48.20792  ? 348 ILE A HD11 1 
ATOM   4861 H  HD12 . ILE A 1 348 ? 5.76900  11.78600  5.82600  1.000 48.20792  ? 348 ILE A HD12 1 
ATOM   4862 H  HD13 . ILE A 1 348 ? 6.40100  11.40900  7.23300  1.000 48.20792  ? 348 ILE A HD13 1 
ATOM   4863 N  N    . SER A 1 349 ? 4.74200  15.75100  8.89200  1.000 29.40294  ? 349 SER A N    1 
ATOM   4864 C  CA   . SER A 1 349 ? 4.31900  16.00500  10.26000 1.000 29.66652  ? 349 SER A CA   1 
ATOM   4865 C  C    . SER A 1 349 ? 4.60700  14.79400  11.14300 1.000 36.02929  ? 349 SER A C    1 
ATOM   4866 O  O    . SER A 1 349 ? 4.93000  13.70100  10.66700 1.000 30.73654  ? 349 SER A O    1 
ATOM   4867 C  CB   . SER A 1 349 ? 2.82800  16.33000  10.31200 1.000 38.81916  ? 349 SER A CB   1 
ATOM   4868 O  OG   . SER A 1 349 ? 2.05600  15.20800  9.91400  1.000 40.57933  ? 349 SER A OG   1 
ATOM   4869 H  H    . SER A 1 349 ? 4.11100  15.47300  8.37800  1.000 35.22329  ? 349 SER A H    1 
ATOM   4870 H  HA   . SER A 1 349 ? 4.81500  16.76600  10.60100 1.000 35.53959  ? 349 SER A HA   1 
ATOM   4871 H  HB2  . SER A 1 349 ? 2.58800  16.57300  11.22000 1.000 46.52275  ? 349 SER A HB2  1 
ATOM   4872 H  HB3  . SER A 1 349 ? 2.64400  17.07000  9.71100  1.000 46.52275  ? 349 SER A HB3  1 
ATOM   4873 H  HG   . SER A 1 349 ? 1.23700  15.38400  9.97800  1.000 48.63496  ? 349 SER A HG   1 
ATOM   4874 N  N    . VAL A 1 350 ? 4.46700  14.99700  12.45600 1.000 30.32275  ? 350 VAL A N    1 
ATOM   4875 C  CA   . VAL A 1 350 ? 4.63300  13.89000  13.39500 1.000 32.20012  ? 350 VAL A CA   1 
ATOM   4876 C  C    . VAL A 1 350 ? 3.57000  12.82700  13.14500 1.000 38.78476  ? 350 VAL A C    1 
ATOM   4877 O  O    . VAL A 1 350 ? 3.86600  11.62800  13.07900 1.000 34.46943  ? 350 VAL A O    1 
ATOM   4878 C  CB   . VAL A 1 350 ? 4.58500  14.40500  14.84600 1.000 33.97419  ? 350 VAL A CB   1 
ATOM   4879 C  CG1  . VAL A 1 350 ? 4.63400  13.24100  15.82700 1.000 36.60684  ? 350 VAL A CG1  1 
ATOM   4880 C  CG2  . VAL A 1 350 ? 5.72800  15.37700  15.10900 1.000 34.32889  ? 350 VAL A CG2  1 
ATOM   4881 H  H    . VAL A 1 350 ? 4.28000  15.75200  12.82000 1.000 36.32706  ? 350 VAL A H    1 
ATOM   4882 H  HA   . VAL A 1 350 ? 5.50400  13.48700  13.24900 1.000 38.57990  ? 350 VAL A HA   1 
ATOM   4883 H  HB   . VAL A 1 350 ? 3.75000  14.87900  14.98100 1.000 40.70879  ? 350 VAL A HB   1 
ATOM   4884 H  HG11 . VAL A 1 350 ? 4.82400  13.58400  16.71400 1.000 43.86797  ? 350 VAL A HG11 1 
ATOM   4885 H  HG12 . VAL A 1 350 ? 3.77600  12.78900  15.82400 1.000 43.86797  ? 350 VAL A HG12 1 
ATOM   4886 H  HG13 . VAL A 1 350 ? 5.33300  12.62700  15.55400 1.000 43.86797  ? 350 VAL A HG13 1 
ATOM   4887 H  HG21 . VAL A 1 350 ? 5.64500  15.72600  16.01000 1.000 41.13443  ? 350 VAL A HG21 1 
ATOM   4888 H  HG22 . VAL A 1 350 ? 6.57100  14.90700  15.01300 1.000 41.13443  ? 350 VAL A HG22 1 
ATOM   4889 H  HG23 . VAL A 1 350 ? 5.67900  16.10300  14.46800 1.000 41.13443  ? 350 VAL A HG23 1 
ATOM   4890 N  N    . ASP A 1 351 ? 2.31400  13.25400  12.99200 1.000 36.67627  ? 351 ASP A N    1 
ATOM   4891 C  CA   . ASP A 1 351 ? 1.22600  12.30000  12.80800 1.000 40.76367  ? 351 ASP A CA   1 
ATOM   4892 C  C    . ASP A 1 351 ? 1.40400  11.49600  11.52500 1.000 37.28617  ? 351 ASP A C    1 
ATOM   4893 O  O    . ASP A 1 351 ? 1.17900  10.28100  11.50800 1.000 42.19952  ? 351 ASP A O    1 
ATOM   4894 C  CB   . ASP A 1 351 ? -0.11500 13.03200  12.79600 1.000 41.83930  ? 351 ASP A CB   1 
ATOM   4895 C  CG   . ASP A 1 351 ? -0.44300 13.67100  14.13100 1.000 55.50742  ? 351 ASP A CG   1 
ATOM   4896 O  OD1  . ASP A 1 351 ? -0.03800 13.11600  15.17500 1.000 44.65399  ? 351 ASP A OD1  1 
ATOM   4897 O  OD2  . ASP A 1 351 ? -1.10500 14.72900  14.13500 1.000 60.92502  ? 351 ASP A OD2  1 
ATOM   4898 H  H    . ASP A 1 351 ? 2.07100  14.07900  12.99100 1.000 43.95129  ? 351 ASP A H    1 
ATOM   4899 H  HA   . ASP A 1 351 ? 1.22600  11.67900  13.55400 1.000 48.85617  ? 351 ASP A HA   1 
ATOM   4900 H  HB2  . ASP A 1 351 ? -0.08700 13.73300  12.12600 1.000 50.14692  ? 351 ASP A HB2  1 
ATOM   4901 H  HB3  . ASP A 1 351 ? -0.82000 12.39900  12.58500 1.000 50.14692  ? 351 ASP A HB3  1 
ATOM   4902 N  N    . ASP A 1 352 ? 1.80800  12.15700  10.43800 1.000 35.26153  ? 352 ASP A N    1 
ATOM   4903 C  CA   . ASP A 1 352 ? 2.00000  11.44400  9.18100  1.000 38.33591  ? 352 ASP A CA   1 
ATOM   4904 C  C    . ASP A 1 352 ? 3.21400  10.52500  9.25100  1.000 40.46159  ? 352 ASP A C    1 
ATOM   4905 O  O    . ASP A 1 352 ? 3.20100  9.42600   8.68400  1.000 34.74509  ? 352 ASP A O    1 
ATOM   4906 C  CB   . ASP A 1 352 ? 2.14200  12.43800  8.02900  1.000 45.39389  ? 352 ASP A CB   1 
ATOM   4907 C  CG   . ASP A 1 352 ? 0.80900  13.02600  7.59600  1.000 51.47938  ? 352 ASP A CG   1 
ATOM   4908 O  OD1  . ASP A 1 352 ? -0.24400 12.43100  7.91400  1.000 50.72690  ? 352 ASP A OD1  1 
ATOM   4909 O  OD2  . ASP A 1 352 ? 0.81400  14.08600  6.93700  1.000 52.05790  ? 352 ASP A OD2  1 
ATOM   4910 H  H    . ASP A 1 352 ? 1.97300  13.00000  10.40500 1.000 42.25360  ? 352 ASP A H    1 
ATOM   4911 H  HA   . ASP A 1 352 ? 1.21800  10.89700  9.00700  1.000 45.94285  ? 352 ASP A HA   1 
ATOM   4912 H  HB2  . ASP A 1 352 ? 2.71500  13.16800  8.30900  1.000 54.41243  ? 352 ASP A HB2  1 
ATOM   4913 H  HB3  . ASP A 1 352 ? 2.53200  11.98400  7.26500  1.000 54.41243  ? 352 ASP A HB3  1 
ATOM   4914 N  N    . ALA A 1 353 ? 4.27400  10.95600  9.93800  1.000 31.40356  ? 353 ALA A N    1 
ATOM   4915 C  CA   . ALA A 1 353 ? 5.43200  10.08800  10.12200 1.000 30.79933  ? 353 ALA A CA   1 
ATOM   4916 C  C    . ALA A 1 353 ? 5.04600  8.82200   10.87600 1.000 30.83248  ? 353 ALA A C    1 
ATOM   4917 O  O    . ALA A 1 353 ? 5.56500  7.73700   10.59300 1.000 30.13415  ? 353 ALA A O    1 
ATOM   4918 C  CB   . ALA A 1 353 ? 6.53900  10.83300  10.86500 1.000 27.44566  ? 353 ALA A CB   1 
ATOM   4919 H  H    . ALA A 1 353 ? 4.34500  11.73300  10.30100 1.000 37.62404  ? 353 ALA A H    1 
ATOM   4920 H  HA   . ALA A 1 353 ? 5.77500  9.83400   9.25100  1.000 36.89896  ? 353 ALA A HA   1 
ATOM   4921 H  HB1  . ALA A 1 353 ? 7.31900  10.26000  10.92700 1.000 32.87455  ? 353 ALA A HB1  1 
ATOM   4922 H  HB2  . ALA A 1 353 ? 6.76000  11.64100  10.37500 1.000 32.87455  ? 353 ALA A HB2  1 
ATOM   4923 H  HB3  . ALA A 1 353 ? 6.22500  11.06200  11.75400 1.000 32.87455  ? 353 ALA A HB3  1 
ATOM   4924 N  N    . LEU A 1 354 ? 4.13300  8.94400   11.84100 1.000 33.68698  ? 354 LEU A N    1 
ATOM   4925 C  CA   . LEU A 1 354 ? 3.69000  7.78500   12.60400 1.000 38.06880  ? 354 LEU A CA   1 
ATOM   4926 C  C    . LEU A 1 354 ? 2.84100  6.83600   11.76600 1.000 37.74999  ? 354 LEU A C    1 
ATOM   4927 O  O    . LEU A 1 354 ? 2.69200  5.66700   12.13800 1.000 35.98113  ? 354 LEU A O    1 
ATOM   4928 C  CB   . LEU A 1 354 ? 2.91300  8.24800   13.83800 1.000 37.10117  ? 354 LEU A CB   1 
ATOM   4929 C  CG   . LEU A 1 354 ? 3.77600  8.68900   15.02600 1.000 41.84136  ? 354 LEU A CG   1 
ATOM   4930 C  CD1  . LEU A 1 354 ? 2.98500  9.58100   15.97400 1.000 40.56708  ? 354 LEU A CD1  1 
ATOM   4931 C  CD2  . LEU A 1 354 ? 4.34300  7.49000   15.77300 1.000 32.50860  ? 354 LEU A CD2  1 
ATOM   4932 H  H    . LEU A 1 354 ? 3.75900  9.68400   12.07000 1.000 40.36414  ? 354 LEU A H    1 
ATOM   4933 H  HA   . LEU A 1 354 ? 4.46400  7.28800   12.91000 1.000 45.62232  ? 354 LEU A HA   1 
ATOM   4934 H  HB2  . LEU A 1 354 ? 2.36000  9.00400   13.58400 1.000 44.46117  ? 354 LEU A HB2  1 
ATOM   4935 H  HB3  . LEU A 1 354 ? 2.35400  7.51500   14.14100 1.000 44.46117  ? 354 LEU A HB3  1 
ATOM   4936 H  HG   . LEU A 1 354 ? 4.52300  9.20300   14.68200 1.000 50.14939  ? 354 LEU A HG   1 
ATOM   4937 H  HD11 . LEU A 1 354 ? 3.55700  9.84100   16.71400 1.000 48.62025  ? 354 LEU A HD11 1 
ATOM   4938 H  HD12 . LEU A 1 354 ? 2.68900  10.36900  15.49300 1.000 48.62025  ? 354 LEU A HD12 1 
ATOM   4939 H  HD13 . LEU A 1 354 ? 2.21900  9.08800   16.30600 1.000 48.62025  ? 354 LEU A HD13 1 
ATOM   4940 H  HD21 . LEU A 1 354 ? 4.84200  7.80500   16.54300 1.000 38.95009  ? 354 LEU A HD21 1 
ATOM   4941 H  HD22 . LEU A 1 354 ? 3.61100  6.92300   16.06200 1.000 38.95009  ? 354 LEU A HD22 1 
ATOM   4942 H  HD23 . LEU A 1 354 ? 4.92900  6.99700   15.17800 1.000 38.95009  ? 354 LEU A HD23 1 
ATOM   4943 N  N    . GLN A 1 355 ? 2.28500  7.31200   10.64900 1.000 39.82235  ? 355 GLN A N    1 
ATOM   4944 C  CA   . GLN A 1 355 ? 1.55300  6.46800   9.71200  1.000 43.54131  ? 355 GLN A CA   1 
ATOM   4945 C  C    . GLN A 1 355 ? 2.43500  5.89700   8.60800  1.000 42.07178  ? 355 GLN A C    1 
ATOM   4946 O  O    . GLN A 1 355 ? 1.96000  5.06500   7.82600  1.000 39.43138  ? 355 GLN A O    1 
ATOM   4947 C  CB   . GLN A 1 355 ? 0.41000  7.25800   9.05800  1.000 44.72326  ? 355 GLN A CB   1 
ATOM   4948 C  CG   . GLN A 1 355 ? -0.67600 7.72900   10.01200 1.000 51.22538  ? 355 GLN A CG   1 
ATOM   4949 C  CD   . GLN A 1 355 ? -1.43500 6.58300   10.65200 1.000 54.66165  ? 355 GLN A CD   1 
ATOM   4950 O  OE1  . GLN A 1 355 ? -1.92700 5.68800   9.96600  1.000 60.55222  ? 355 GLN A OE1  1 
ATOM   4951 N  NE2  . GLN A 1 355 ? -1.53900 6.60900   11.97600 1.000 61.52338  ? 355 GLN A NE2  1 
ATOM   4952 H  H    . GLN A 1 355 ? 2.32200  8.13700   10.40900 1.000 47.72658  ? 355 GLN A H    1 
ATOM   4953 H  HA   . GLN A 1 355 ? 1.16700  5.73100   10.21100 1.000 52.18933  ? 355 GLN A HA   1 
ATOM   4954 H  HB2  . GLN A 1 355 ? 0.78500  8.04500   8.63300  1.000 53.60767  ? 355 GLN A HB2  1 
ATOM   4955 H  HB3  . GLN A 1 355 ? -0.01300 6.69200   8.39300  1.000 53.60767  ? 355 GLN A HB3  1 
ATOM   4956 H  HG2  . GLN A 1 355 ? -0.26800 8.25100   10.72100 1.000 61.41022  ? 355 GLN A HG2  1 
ATOM   4957 H  HG3  . GLN A 1 355 ? -1.31200 8.27400   9.52300  1.000 61.41022  ? 355 GLN A HG3  1 
ATOM   4958 H  HE21 . GLN A 1 355 ? -1.18600 7.25400   12.42200 1.000 73.76781  ? 355 GLN A HE21 1 
ATOM   4959 H  HE22 . GLN A 1 355 ? -1.96000 5.98200   12.38700 1.000 73.76781  ? 355 GLN A HE22 1 
ATOM   4960 N  N    . HIS A 1 356 ? 3.69000  6.32300   8.52000  1.000 33.23679  ? 356 HIS A N    1 
ATOM   4961 C  CA   . HIS A 1 356 ? 4.55600  5.86900   7.44200  1.000 32.12189  ? 356 HIS A CA   1 
ATOM   4962 C  C    . HIS A 1 356 ? 4.76200  4.35600   7.53600  1.000 32.40568  ? 356 HIS A C    1 
ATOM   4963 O  O    . HIS A 1 356 ? 4.83700  3.80800   8.64300  1.000 30.64102  ? 356 HIS A O    1 
ATOM   4964 C  CB   . HIS A 1 356 ? 5.90000  6.59800   7.50600  1.000 28.11204  ? 356 HIS A CB   1 
ATOM   4965 C  CG   . HIS A 1 356 ? 6.72700  6.44400   6.26900  1.000 29.16139  ? 356 HIS A CG   1 
ATOM   4966 N  ND1  . HIS A 1 356 ? 7.49200  5.32600   6.02200  1.000 29.25379  ? 356 HIS A ND1  1 
ATOM   4967 C  CD2  . HIS A 1 356 ? 6.88700  7.25400   5.19600  1.000 27.27417  ? 356 HIS A CD2  1 
ATOM   4968 C  CE1  . HIS A 1 356 ? 8.10000  5.45900   4.85600  1.000 35.10199  ? 356 HIS A CE1  1 
ATOM   4969 N  NE2  . HIS A 1 356 ? 7.75000  6.62100   4.33400  1.000 29.03055  ? 356 HIS A NE2  1 
ATOM   4970 H  H    . HIS A 1 356 ? 4.06100  6.87200   9.06700  1.000 39.82391  ? 356 HIS A H    1 
ATOM   4971 H  HA   . HIS A 1 356 ? 4.14500  6.06100   6.58500  1.000 38.48603  ? 356 HIS A HA   1 
ATOM   4972 H  HB2  . HIS A 1 356 ? 5.73500  7.54500   7.63700  1.000 33.67421  ? 356 HIS A HB2  1 
ATOM   4973 H  HB3  . HIS A 1 356 ? 6.41200  6.24400   8.25000  1.000 33.67421  ? 356 HIS A HB3  1 
ATOM   4974 H  HD2  . HIS A 1 356 ? 6.48800  8.08400   5.06600  1.000 32.66877  ? 356 HIS A HD2  1 
ATOM   4975 H  HE1  . HIS A 1 356 ? 8.67600  4.84000   4.46900  1.000 42.06215  ? 356 HIS A HE1  1 
ATOM   4976 H  HE2  . HIS A 1 356 ? 8.01900  6.93100   3.57800  1.000 34.77642  ? 356 HIS A HE2  1 
ATOM   4977 N  N    . PRO A 1 357 ? 4.84900  3.65100   6.40300  1.000 37.51391  ? 357 PRO A N    1 
ATOM   4978 C  CA   . PRO A 1 357 ? 5.01200  2.18600   6.47000  1.000 36.12518  ? 357 PRO A CA   1 
ATOM   4979 C  C    . PRO A 1 357 ? 6.24600  1.72900   7.23100  1.000 32.79628  ? 357 PRO A C    1 
ATOM   4980 O  O    . PRO A 1 357 ? 6.22000  0.64300   7.82000  1.000 29.76103  ? 357 PRO A O    1 
ATOM   4981 C  CB   . PRO A 1 357 ? 5.07200  1.77000   4.99000  1.000 35.94656  ? 357 PRO A CB   1 
ATOM   4982 C  CG   . PRO A 1 357 ? 5.31300  3.03300   4.22100  1.000 31.58504  ? 357 PRO A CG   1 
ATOM   4983 C  CD   . PRO A 1 357 ? 4.65000  4.10900   5.01600  1.000 36.26328  ? 357 PRO A CD   1 
ATOM   4984 H  HA   . PRO A 1 357 ? 4.22700  1.79600   6.88600  1.000 43.28998  ? 357 PRO A HA   1 
ATOM   4985 H  HB2  . PRO A 1 357 ? 5.79900  1.14100   4.85600  1.000 43.07563  ? 357 PRO A HB2  1 
ATOM   4986 H  HB3  . PRO A 1 357 ? 4.23000  1.36400   4.73000  1.000 43.07563  ? 357 PRO A HB3  1 
ATOM   4987 H  HG2  . PRO A 1 357 ? 6.26700  3.19600   4.14600  1.000 37.84182  ? 357 PRO A HG2  1 
ATOM   4988 H  HG3  . PRO A 1 357 ? 4.91800  2.96200   3.33800  1.000 37.84182  ? 357 PRO A HG3  1 
ATOM   4989 H  HD2  . PRO A 1 357 ? 5.07900  4.96600   4.86800  1.000 43.45570  ? 357 PRO A HD2  1 
ATOM   4990 H  HD3  . PRO A 1 357 ? 3.70600  4.16900   4.80100  1.000 43.45570  ? 357 PRO A HD3  1 
ATOM   4991 N  N    . TYR A 1 358 ? 7.32800  2.51200   7.23600  1.000 30.15970  ? 358 TYR A N    1 
ATOM   4992 C  CA   . TYR A 1 358 ? 8.49600  2.12100   8.01800  1.000 29.46716  ? 358 TYR A CA   1 
ATOM   4993 C  C    . TYR A 1 358 ? 8.19300  2.12500   9.51000  1.000 30.66407  ? 358 TYR A C    1 
ATOM   4994 O  O    . TYR A 1 358 ? 8.81000  1.36600   10.26700 1.000 25.96881  ? 358 TYR A O    1 
ATOM   4995 C  CB   . TYR A 1 358 ? 9.67400  3.05400   7.72600  1.000 29.99593  ? 358 TYR A CB   1 
ATOM   4996 C  CG   . TYR A 1 358 ? 11.01000 2.50300   8.17800  1.000 29.08261  ? 358 TYR A CG   1 
ATOM   4997 C  CD1  . TYR A 1 358 ? 11.52700 1.33700   7.62300  1.000 26.59898  ? 358 TYR A CD1  1 
ATOM   4998 C  CD2  . TYR A 1 358 ? 11.75200 3.14100   9.16700  1.000 24.28761  ? 358 TYR A CD2  1 
ATOM   4999 C  CE1  . TYR A 1 358 ? 12.74500 0.82700   8.03400  1.000 29.03415  ? 358 TYR A CE1  1 
ATOM   5000 C  CE2  . TYR A 1 358 ? 12.97200 2.63500   9.58600  1.000 23.29811  ? 358 TYR A CE2  1 
ATOM   5001 C  CZ   . TYR A 1 358 ? 13.46300 1.47800   9.01700  1.000 23.64552  ? 358 TYR A CZ   1 
ATOM   5002 O  OH   . TYR A 1 358 ? 14.67700 0.97400   9.43000  1.000 27.46821  ? 358 TYR A OH   1 
ATOM   5003 H  H    . TYR A 1 358 ? 7.40800  3.25200   6.80600  1.000 36.13140  ? 358 TYR A H    1 
ATOM   5004 H  HA   . TYR A 1 358 ? 8.75400  1.22400   7.75600  1.000 35.30035  ? 358 TYR A HA   1 
ATOM   5005 H  HB2  . TYR A 1 358 ? 9.72300  3.20500   6.76900  1.000 35.93488  ? 358 TYR A HB2  1 
ATOM   5006 H  HB3  . TYR A 1 358 ? 9.52800  3.89500   8.18700  1.000 35.93488  ? 358 TYR A HB3  1 
ATOM   5007 H  HD1  . TYR A 1 358 ? 11.04500 0.89200   6.96400  1.000 31.85853  ? 358 TYR A HD1  1 
ATOM   5008 H  HD2  . TYR A 1 358 ? 11.42400 3.92000   9.55400  1.000 29.08489  ? 358 TYR A HD2  1 
ATOM   5009 H  HE1  . TYR A 1 358 ? 13.08000 0.04900   7.65000  1.000 34.78074  ? 358 TYR A HE1  1 
ATOM   5010 H  HE2  . TYR A 1 358 ? 13.45700 3.07300   10.24800 1.000 27.89749  ? 358 TYR A HE2  1 
ATOM   5011 H  HH   . TYR A 1 358 ? 15.24500 1.05500   8.81700  1.000 32.90161  ? 358 TYR A HH   1 
ATOM   5012 N  N    . ILE A 1 359 ? 7.24300  2.94900   9.94200  1.000 33.20441  ? 359 ILE A N    1 
ATOM   5013 C  CA   . ILE A 1 359 ? 7.02500  3.21700   11.35600 1.000 29.56872  ? 359 ILE A CA   1 
ATOM   5014 C  C    . ILE A 1 359 ? 5.79000  2.50400   11.89100 1.000 33.30450  ? 359 ILE A C    1 
ATOM   5015 O  O    . ILE A 1 359 ? 5.80600  2.00800   13.01700 1.000 33.25786  ? 359 ILE A O    1 
ATOM   5016 C  CB   . ILE A 1 359 ? 6.92200  4.74100   11.59800 1.000 27.89810  ? 359 ILE A CB   1 
ATOM   5017 C  CG1  . ILE A 1 359 ? 8.18700  5.46100   11.12100 1.000 25.84944  ? 359 ILE A CG1  1 
ATOM   5018 C  CG2  . ILE A 1 359 ? 6.66600  5.02500   13.06800 1.000 28.37862  ? 359 ILE A CG2  1 
ATOM   5019 C  CD1  . ILE A 1 359 ? 9.41200  5.19200   11.96100 1.000 29.04749  ? 359 ILE A CD1  1 
ATOM   5020 H  H    . ILE A 1 359 ? 6.70200  3.37200   9.42400  1.000 39.78506  ? 359 ILE A H    1 
ATOM   5021 H  HA   . ILE A 1 359 ? 7.79000  2.88000   11.84800 1.000 35.42222  ? 359 ILE A HA   1 
ATOM   5022 H  HB   . ILE A 1 359 ? 6.17500  5.07700   11.07900 1.000 33.41749  ? 359 ILE A HB   1 
ATOM   5023 H  HG12 . ILE A 1 359 ? 8.38400  5.17400   10.21600 1.000 30.95909  ? 359 ILE A HG12 1 
ATOM   5024 H  HG13 . ILE A 1 359 ? 8.02400  6.41700   11.13800 1.000 30.95909  ? 359 ILE A HG13 1 
ATOM   5025 H  HG21 . ILE A 1 359 ? 6.85800  5.95900   13.24700 1.000 33.99410  ? 359 ILE A HG21 1 
ATOM   5026 H  HG22 . ILE A 1 359 ? 5.73700  4.83400   13.27000 1.000 33.99410  ? 359 ILE A HG22 1 
ATOM   5027 H  HG23 . ILE A 1 359 ? 7.24400  4.46000   13.60400 1.000 33.99410  ? 359 ILE A HG23 1 
ATOM   5028 H  HD11 . ILE A 1 359 ? 10.19300 5.53300   11.49900 1.000 34.79675  ? 359 ILE A HD11 1 
ATOM   5029 H  HD12 . ILE A 1 359 ? 9.31300  5.63800   12.81600 1.000 34.79675  ? 359 ILE A HD12 1 
ATOM   5030 H  HD13 . ILE A 1 359 ? 9.49900  4.23500   12.09600 1.000 34.79675  ? 359 ILE A HD13 1 
ATOM   5031 N  N    . ASN A 1 360 ? 4.70700  2.43800   11.11000 1.000 34.33291  ? 360 ASN A N    1 
ATOM   5032 C  CA   . ASN A 1 360 ? 3.42000  2.07400   11.69800 1.000 33.12759  ? 360 ASN A CA   1 
ATOM   5033 C  C    . ASN A 1 360 ? 3.29800  0.59700   12.04400 1.000 34.09188  ? 360 ASN A C    1 
ATOM   5034 O  O    . ASN A 1 360 ? 2.27000  0.21000   12.60900 1.000 41.18239  ? 360 ASN A O    1 
ATOM   5035 C  CB   . ASN A 1 360 ? 2.26400  2.45800   10.76900 1.000 41.22609  ? 360 ASN A CB   1 
ATOM   5036 C  CG   . ASN A 1 360 ? 2.29000  1.70200   9.45900  1.000 46.96202  ? 360 ASN A CG   1 
ATOM   5037 O  OD1  . ASN A 1 360 ? 2.62500  2.26300   8.41700  1.000 55.72764  ? 360 ASN A OD1  1 
ATOM   5038 N  ND2  . ASN A 1 360 ? 1.93100  0.42300   9.50000  1.000 47.54437  ? 360 ASN A ND2  1 
ATOM   5039 H  H    . ASN A 1 360 ? 4.69500  2.59600   10.26500 1.000 41.13925  ? 360 ASN A H    1 
ATOM   5040 H  HA   . ASN A 1 360 ? 3.33300  2.58400   12.51800 1.000 39.69287  ? 360 ASN A HA   1 
ATOM   5041 H  HB2  . ASN A 1 360 ? 1.42400  2.26200   11.21200 1.000 49.41107  ? 360 ASN A HB2  1 
ATOM   5042 H  HB3  . ASN A 1 360 ? 2.32000  3.40600   10.56900 1.000 49.41107  ? 360 ASN A HB3  1 
ATOM   5043 H  HD21 . ASN A 1 360 ? 1.69900  0.06600   10.24700 1.000 56.99300  ? 360 ASN A HD21 1 
ATOM   5044 H  HD22 . ASN A 1 360 ? 1.93000  -0.04600  8.77900  1.000 56.99300  ? 360 ASN A HD22 1 
ATOM   5045 N  N    . VAL A 1 361 ? 4.28200  -0.24400  11.71900 1.000 30.54835  ? 361 VAL A N    1 
ATOM   5046 C  CA   . VAL A 1 361 ? 4.21800  -1.63800  12.12800 1.000 34.09540  ? 361 VAL A CA   1 
ATOM   5047 C  C    . VAL A 1 361 ? 4.23700  -1.78800  13.64500 1.000 42.19335  ? 361 VAL A C    1 
ATOM   5048 O  O    . VAL A 1 361 ? 3.94000  -2.87000  14.15800 1.000 39.53722  ? 361 VAL A O    1 
ATOM   5049 C  CB   . VAL A 1 361 ? 5.36900  -2.44800  11.48700 1.000 34.40236  ? 361 VAL A CB   1 
ATOM   5050 C  CG1  . VAL A 1 361 ? 5.26300  -2.41100  9.96600  1.000 45.50898  ? 361 VAL A CG1  1 
ATOM   5051 C  CG2  . VAL A 1 361 ? 6.72300  -1.92600  11.94300 1.000 34.48320  ? 361 VAL A CG2  1 
ATOM   5052 H  H    . VAL A 1 361 ? 4.98300  -0.03000  11.27000 1.000 36.59778  ? 361 VAL A H    1 
ATOM   5053 H  HA   . VAL A 1 361 ? 3.38500  -2.01300  11.80200 1.000 40.85424  ? 361 VAL A HA   1 
ATOM   5054 H  HB   . VAL A 1 361 ? 5.29500  -3.37000  11.77700 1.000 41.22259  ? 361 VAL A HB   1 
ATOM   5055 H  HG11 . VAL A 1 361 ? 5.99200  -2.92500  9.58600  1.000 54.55054  ? 361 VAL A HG11 1 
ATOM   5056 H  HG12 . VAL A 1 361 ? 4.41300  -2.79500  9.70000  1.000 54.55054  ? 361 VAL A HG12 1 
ATOM   5057 H  HG13 . VAL A 1 361 ? 5.31700  -1.48900  9.66800  1.000 54.55054  ? 361 VAL A HG13 1 
ATOM   5058 H  HG21 . VAL A 1 361 ? 7.42200  -2.44600  11.51600 1.000 41.31960  ? 361 VAL A HG21 1 
ATOM   5059 H  HG22 . VAL A 1 361 ? 6.80400  -0.99300  11.68900 1.000 41.31960  ? 361 VAL A HG22 1 
ATOM   5060 H  HG23 . VAL A 1 361 ? 6.78800  -2.01300  12.90600 1.000 41.31960  ? 361 VAL A HG23 1 
ATOM   5061 N  N    . TRP A 1 362 ? 4.57100  -0.72400  14.37700 1.000 36.38713  ? 362 TRP A N    1 
ATOM   5062 C  CA   . TRP A 1 362 ? 4.57000  -0.73500  15.83300 1.000 37.86215  ? 362 TRP A CA   1 
ATOM   5063 C  C    . TRP A 1 362 ? 3.36500  -0.01600  16.43100 1.000 40.92839  ? 362 TRP A C    1 
ATOM   5064 O  O    . TRP A 1 362 ? 3.23000  0.02100   17.65600 1.000 46.28773  ? 362 TRP A O    1 
ATOM   5065 C  CB   . TRP A 1 362 ? 5.85900  -0.09200  16.36200 1.000 34.96871  ? 362 TRP A CB   1 
ATOM   5066 C  CG   . TRP A 1 362 ? 7.11000  -0.74000  15.85000 1.000 33.63608  ? 362 TRP A CG   1 
ATOM   5067 C  CD1  . TRP A 1 362 ? 7.90900  -0.29500  14.84000 1.000 30.96547  ? 362 TRP A CD1  1 
ATOM   5068 C  CD2  . TRP A 1 362 ? 7.70400  -1.95600  16.32500 1.000 40.60698  ? 362 TRP A CD2  1 
ATOM   5069 N  NE1  . TRP A 1 362 ? 8.96500  -1.15400  14.65600 1.000 33.22606  ? 362 TRP A NE1  1 
ATOM   5070 C  CE2  . TRP A 1 362 ? 8.86100  -2.18400  15.55400 1.000 33.92958  ? 362 TRP A CE2  1 
ATOM   5071 C  CE3  . TRP A 1 362 ? 7.37000  -2.87100  17.32700 1.000 36.42656  ? 362 TRP A CE3  1 
ATOM   5072 C  CZ2  . TRP A 1 362 ? 9.68400  -3.29000  15.75200 1.000 37.81724  ? 362 TRP A CZ2  1 
ATOM   5073 C  CZ3  . TRP A 1 362 ? 8.19000  -3.96900  17.52400 1.000 43.32706  ? 362 TRP A CZ3  1 
ATOM   5074 C  CH2  . TRP A 1 362 ? 9.33400  -4.16800  16.74000 1.000 40.07595  ? 362 TRP A CH2  1 
ATOM   5075 H  H    . TRP A 1 362 ? 4.80600  0.03200   14.04100 1.000 43.60432  ? 362 TRP A H    1 
ATOM   5076 H  HA   . TRP A 1 362 ? 4.54700  -1.65700  16.13400 1.000 45.37434  ? 362 TRP A HA   1 
ATOM   5077 H  HB2  . TRP A 1 362 ? 5.87600  0.84000   16.09300 1.000 41.90221  ? 362 TRP A HB2  1 
ATOM   5078 H  HB3  . TRP A 1 362 ? 5.86600  -0.15800  17.33000 1.000 41.90221  ? 362 TRP A HB3  1 
ATOM   5079 H  HD1  . TRP A 1 362 ? 7.76000  0.47900   14.34600 1.000 37.09833  ? 362 TRP A HD1  1 
ATOM   5080 H  HE1  . TRP A 1 362 ? 9.59100  -1.06100  14.07300 1.000 39.81104  ? 362 TRP A HE1  1 
ATOM   5081 H  HE3  . TRP A 1 362 ? 6.61100  -2.74600  17.85000 1.000 43.65164  ? 362 TRP A HE3  1 
ATOM   5082 H  HZ2  . TRP A 1 362 ? 10.44400 -3.42500  15.23300 1.000 45.32045  ? 362 TRP A HZ2  1 
ATOM   5083 H  HZ3  . TRP A 1 362 ? 7.97800  -4.58500  18.18800 1.000 51.93223  ? 362 TRP A HZ3  1 
ATOM   5084 H  HH2  . TRP A 1 362 ? 9.86700  -4.91400  16.89500 1.000 48.03090  ? 362 TRP A HH2  1 
ATOM   5085 N  N    . TYR A 1 363 ? 2.48600  0.53800   15.59400 1.000 41.52666  ? 363 TYR A N    1 
ATOM   5086 C  CA   . TYR A 1 363 ? 1.40200  1.40800   16.05600 1.000 56.51865  ? 363 TYR A CA   1 
ATOM   5087 C  C    . TYR A 1 363 ? 0.52400  0.73600   17.10900 1.000 70.88212  ? 363 TYR A C    1 
ATOM   5088 O  O    . TYR A 1 363 ? 0.42400  -0.48400  17.18800 1.000 68.05756  ? 363 TYR A O    1 
ATOM   5089 C  CB   . TYR A 1 363 ? 0.53500  1.82500   14.86300 1.000 60.71079  ? 363 TYR A CB   1 
ATOM   5090 C  CG   . TYR A 1 363 ? -0.14900 3.16500   15.04000 1.000 82.73323  ? 363 TYR A CG   1 
ATOM   5091 C  CD1  . TYR A 1 363 ? -1.32900 3.27400   15.76400 1.000 84.35312  ? 363 TYR A CD1  1 
ATOM   5092 C  CD2  . TYR A 1 363 ? 0.38600  4.32000   14.48300 1.000 72.29511  ? 363 TYR A CD2  1 
ATOM   5093 C  CE1  . TYR A 1 363 ? -1.95800 4.49400   15.93000 1.000 93.71213  ? 363 TYR A CE1  1 
ATOM   5094 C  CE2  . TYR A 1 363 ? -0.23600 5.54500   14.64300 1.000 74.79132  ? 363 TYR A CE2  1 
ATOM   5095 C  CZ   . TYR A 1 363 ? -1.40800 5.62600   15.36700 1.000 83.79893  ? 363 TYR A CZ   1 
ATOM   5096 O  OH   . TYR A 1 363 ? -2.03300 6.84100   15.53100 1.000 76.00594  ? 363 TYR A OH   1 
ATOM   5097 H  H    . TYR A 1 363 ? 2.49500  0.42500   14.74100 1.000 49.77175  ? 363 TYR A H    1 
ATOM   5098 H  HA   . TYR A 1 363 ? 1.79500  2.19300   16.46800 1.000 67.76214  ? 363 TYR A HA   1 
ATOM   5099 H  HB2  . TYR A 1 363 ? 1.09600  1.88200   14.07400 1.000 72.79272  ? 363 TYR A HB2  1 
ATOM   5100 H  HB3  . TYR A 1 363 ? -0.15600 1.15600   14.73100 1.000 72.79272  ? 363 TYR A HB3  1 
ATOM   5101 H  HD1  . TYR A 1 363 ? -1.70400 2.51300   16.14500 1.000 101.16351 ? 363 TYR A HD1  1 
ATOM   5102 H  HD2  . TYR A 1 363 ? 1.17600  4.26900   13.99400 1.000 86.69390  ? 363 TYR A HD2  1 
ATOM   5103 H  HE1  . TYR A 1 363 ? -2.74700 4.55100   16.41800 1.000 112.39432 ? 363 TYR A HE1  1 
ATOM   5104 H  HE2  . TYR A 1 363 ? 0.13300  6.31000   14.26400 1.000 89.68935  ? 363 TYR A HE2  1 
ATOM   5105 H  HH   . TYR A 1 363 ? -2.72700 6.74600   15.99400 1.000 91.14690  ? 363 TYR A HH   1 
ATOM   5106 N  N    . ASP A 1 364 ? -0.12300 1.57800   17.93100 1.000 86.61985  ? 364 ASP A N    1 
ATOM   5107 C  CA   . ASP A 1 364 ? -1.10100 1.16700   18.93500 1.000 99.07430  ? 364 ASP A CA   1 
ATOM   5108 C  C    . ASP A 1 364 ? -1.68500 2.42700   19.56900 1.000 108.22022 ? 364 ASP A C    1 
ATOM   5109 O  O    . ASP A 1 364 ? -0.92700 3.30400   20.00200 1.000 105.61546 ? 364 ASP A O    1 
ATOM   5110 C  CB   . ASP A 1 364 ? -0.46200 0.26800   19.99400 1.000 95.70216  ? 364 ASP A CB   1 
ATOM   5111 C  CG   . ASP A 1 364 ? -1.49000 -0.52400  20.77900 1.000 102.20892 ? 364 ASP A CG   1 
ATOM   5112 O  OD1  . ASP A 1 364 ? -2.38500 -1.12900  20.15100 1.000 110.08825 ? 364 ASP A OD1  1 
ATOM   5113 O  OD2  . ASP A 1 364 ? -1.40400 -0.54000  22.02500 1.000 111.27025 ? 364 ASP A OD2  1 
ATOM   5114 H  H    . ASP A 1 364 ? -0.00300 2.43000   17.92200 1.000 103.88359 ? 364 ASP A H    1 
ATOM   5115 H  HA   . ASP A 1 364 ? -1.81200 0.65200   18.52300 1.000 118.82892 ? 364 ASP A HA   1 
ATOM   5116 H  HB2  . ASP A 1 364 ? 0.13400  -0.36100  19.55900 1.000 114.78236 ? 364 ASP A HB2  1 
ATOM   5117 H  HB3  . ASP A 1 364 ? 0.03500  0.81900   20.61900 1.000 114.78236 ? 364 ASP A HB3  1 
ATOM   5118 N  N    . PRO A 1 365 ? -3.01500 2.56700   19.63500 1.000 114.02654 ? 365 PRO A N    1 
ATOM   5119 C  CA   . PRO A 1 365 ? -3.58800 3.83000   20.13700 1.000 113.09950 ? 365 PRO A CA   1 
ATOM   5120 C  C    . PRO A 1 365 ? -3.07900 4.25200   21.50600 1.000 119.49685 ? 365 PRO A C    1 
ATOM   5121 O  O    . PRO A 1 365 ? -2.86500 5.44800   21.73700 1.000 118.61729 ? 365 PRO A O    1 
ATOM   5122 C  CB   . PRO A 1 365 ? -5.09500 3.53500   20.17000 1.000 110.51359 ? 365 PRO A CB   1 
ATOM   5123 C  CG   . PRO A 1 365 ? -5.29900 2.48900   19.15000 1.000 112.42299 ? 365 PRO A CG   1 
ATOM   5124 C  CD   . PRO A 1 365 ? -4.05400 1.65100   19.13100 1.000 114.65242 ? 365 PRO A CD   1 
ATOM   5125 H  HA   . PRO A 1 365 ? -3.40000 4.53600   19.49900 1.000 135.65916 ? 365 PRO A HA   1 
ATOM   5126 H  HB2  . PRO A 1 365 ? -5.35100 3.21800   21.05000 1.000 132.55608 ? 365 PRO A HB2  1 
ATOM   5127 H  HB3  . PRO A 1 365 ? -5.59400 4.33800   19.94900 1.000 132.55608 ? 365 PRO A HB3  1 
ATOM   5128 H  HG2  . PRO A 1 365 ? -6.06800 1.94900   19.39000 1.000 134.84735 ? 365 PRO A HG2  1 
ATOM   5129 H  HG3  . PRO A 1 365 ? -5.44200 2.90400   18.28500 1.000 134.84735 ? 365 PRO A HG3  1 
ATOM   5130 H  HD2  . PRO A 1 365 ? -4.14800 0.88200   19.71500 1.000 137.52267 ? 365 PRO A HD2  1 
ATOM   5131 H  HD3  . PRO A 1 365 ? -3.84900 1.35900   18.22900 1.000 137.52267 ? 365 PRO A HD3  1 
ATOM   5132 N  N    . ALA A 1 366 ? -2.88400 3.30500   22.42500 1.000 121.20238 ? 366 ALA A N    1 
ATOM   5133 C  CA   . ALA A 1 366 ? -2.50400 3.66200   23.78600 1.000 119.25891 ? 366 ALA A CA   1 
ATOM   5134 C  C    . ALA A 1 366 ? -1.15500 4.36600   23.85200 1.000 125.49954 ? 366 ALA A C    1 
ATOM   5135 O  O    . ALA A 1 366 ? -0.90800 5.11700   24.80200 1.000 125.76193 ? 366 ALA A O    1 
ATOM   5136 C  CB   . ALA A 1 366 ? -2.47600 2.41200   24.66800 1.000 112.96394 ? 366 ALA A CB   1 
ATOM   5137 H  H    . ALA A 1 366 ? -2.96600 2.46000   22.28600 1.000 145.38262 ? 366 ALA A H    1 
ATOM   5138 H  HA   . ALA A 1 366 ? -3.17100 4.27000   24.14000 1.000 143.05045 ? 366 ALA A HA   1 
ATOM   5139 H  HB1  . ALA A 1 366 ? -2.22000 2.66700   25.56800 1.000 135.49649 ? 366 ALA A HB1  1 
ATOM   5140 H  HB2  . ALA A 1 366 ? -3.35900 2.01200   24.67600 1.000 135.49649 ? 366 ALA A HB2  1 
ATOM   5141 H  HB3  . ALA A 1 366 ? -1.83100 1.78500   24.30600 1.000 135.49649 ? 366 ALA A HB3  1 
ATOM   5142 N  N    . GLU A 1 367 ? -0.27900 4.15000   22.87000 1.000 135.31165 ? 367 GLU A N    1 
ATOM   5143 C  CA   . GLU A 1 367 ? 1.06100  4.72200   22.91400 1.000 135.52471 ? 367 GLU A CA   1 
ATOM   5144 C  C    . GLU A 1 367 ? 1.11200  6.13100   22.32700 1.000 116.31126 ? 367 GLU A C    1 
ATOM   5145 O  O    . GLU A 1 367 ? 1.70900  7.03000   22.92700 1.000 102.56215 ? 367 GLU A O    1 
ATOM   5146 C  CB   . GLU A 1 367 ? 2.05100  3.81800   22.17000 1.000 122.46720 ? 367 GLU A CB   1 
ATOM   5147 C  CG   . GLU A 1 367 ? 1.87800  2.32700   22.42600 1.000 118.04640 ? 367 GLU A CG   1 
ATOM   5148 C  CD   . GLU A 1 367 ? 1.55900  1.99800   23.87300 1.000 141.42283 ? 367 GLU A CD   1 
ATOM   5149 O  OE1  . GLU A 1 367 ? 2.00500  2.74100   24.77300 1.000 145.55937 ? 367 GLU A OE1  1 
ATOM   5150 O  OE2  . GLU A 1 367 ? 0.85600  0.99300   24.11100 1.000 139.72253 ? 367 GLU A OE2  1 
ATOM   5151 H  H    . GLU A 1 367 ? -0.44000 3.67700   22.17000 1.000 162.31374 ? 367 GLU A H    1 
ATOM   5152 H  HA   . GLU A 1 367 ? 1.33200  4.77400   23.84300 1.000 162.56942 ? 367 GLU A HA   1 
ATOM   5153 H  HB2  . GLU A 1 367 ? 1.94400  3.96300   21.21700 1.000 146.90041 ? 367 GLU A HB2  1 
ATOM   5154 H  HB3  . GLU A 1 367 ? 2.95000  4.05700   22.44400 1.000 146.90041 ? 367 GLU A HB3  1 
ATOM   5155 H  HG2  . GLU A 1 367 ? 1.14900  1.99700   21.87900 1.000 141.59544 ? 367 GLU A HG2  1 
ATOM   5156 H  HG3  . GLU A 1 367 ? 2.70200  1.87100   22.19200 1.000 141.59544 ? 367 GLU A HG3  1 
ATOM   5157 N  N    . VAL A 1 368 ? 0.50000  6.34200   21.16200 1.000 118.35761 ? 368 VAL A N    1 
ATOM   5158 C  CA   . VAL A 1 368 ? 0.66100  7.62500   20.48600 1.000 110.83354 ? 368 VAL A CA   1 
ATOM   5159 C  C    . VAL A 1 368 ? -0.21000 8.69900   21.13300 1.000 116.16181 ? 368 VAL A C    1 
ATOM   5160 O  O    . VAL A 1 368 ? 0.23300  9.83700   21.31400 1.000 117.12789 ? 368 VAL A O    1 
ATOM   5161 C  CB   . VAL A 1 368 ? 0.38000  7.47800   18.97600 1.000 101.32463 ? 368 VAL A CB   1 
ATOM   5162 C  CG1  . VAL A 1 368 ? 1.25400  6.37800   18.38000 1.000 88.47802  ? 368 VAL A CG1  1 
ATOM   5163 C  CG2  . VAL A 1 368 ? -1.08700 7.19100   18.70400 1.000 105.33181 ? 368 VAL A CG2  1 
ATOM   5164 H  H    . VAL A 1 368 ? -0.00100 5.77400   20.75400 1.000 141.96889 ? 368 VAL A H    1 
ATOM   5165 H  HA   . VAL A 1 368 ? 1.58400  7.90500   20.58300 1.000 132.94001 ? 368 VAL A HA   1 
ATOM   5166 H  HB   . VAL A 1 368 ? 0.59600  8.32000   18.54700 1.000 121.52932 ? 368 VAL A HB   1 
ATOM   5167 H  HG11 . VAL A 1 368 ? 1.10400  6.34100   17.42200 1.000 106.11339 ? 368 VAL A HG11 1 
ATOM   5168 H  HG12 . VAL A 1 368 ? 2.18500  6.58200   18.56100 1.000 106.11339 ? 368 VAL A HG12 1 
ATOM   5169 H  HG13 . VAL A 1 368 ? 1.01600  5.53000   18.78600 1.000 106.11339 ? 368 VAL A HG13 1 
ATOM   5170 H  HG21 . VAL A 1 368 ? -1.15300 6.50000   18.02600 1.000 126.33794 ? 368 VAL A HG21 1 
ATOM   5171 H  HG22 . VAL A 1 368 ? -1.50800 6.89000   19.52400 1.000 126.33794 ? 368 VAL A HG22 1 
ATOM   5172 H  HG23 . VAL A 1 368 ? -1.51500 8.00300   18.39100 1.000 126.33794 ? 368 VAL A HG23 1 
ATOM   5173 N  N    . GLU A 1 369 ? -1.43800 8.36500   21.52600 1.000 118.29923 ? 369 GLU A N    1 
ATOM   5174 C  CA   . GLU A 1 369 ? -2.34600 9.33800   22.13500 1.000 121.83240 ? 369 GLU A CA   1 
ATOM   5175 C  C    . GLU A 1 369 ? -2.67100 8.91100   23.56300 1.000 119.64390 ? 369 GLU A C    1 
ATOM   5176 O  O    . GLU A 1 369 ? -3.63600 8.18300   23.81000 1.000 115.22109 ? 369 GLU A O    1 
ATOM   5177 C  CB   . GLU A 1 369 ? -3.61500 9.50400   21.29700 1.000 118.35538 ? 369 GLU A CB   1 
ATOM   5178 C  CG   . GLU A 1 369 ? -3.33800 9.98800   19.88600 1.000 116.90574 ? 369 GLU A CG   1 
ATOM   5179 C  CD   . GLU A 1 369 ? -4.59700 10.32500  19.11700 1.000 114.41526 ? 369 GLU A CD   1 
ATOM   5180 O  OE1  . GLU A 1 369 ? -5.70200 10.12200  19.66100 1.000 119.11749 ? 369 GLU A OE1  1 
ATOM   5181 O  OE2  . GLU A 1 369 ? -4.47900 10.79700  17.96600 1.000 109.74830 ? 369 GLU A OE2  1 
ATOM   5182 H  H    . GLU A 1 369 ? -1.77000 7.57600   21.45100 1.000 141.89884 ? 369 GLU A H    1 
ATOM   5183 H  HA   . GLU A 1 369 ? -1.88400 10.19000  22.18400 1.000 146.13864 ? 369 GLU A HA   1 
ATOM   5184 H  HB2  . GLU A 1 369 ? -4.06500 8.64700   21.23500 1.000 141.96621 ? 369 GLU A HB2  1 
ATOM   5185 H  HB3  . GLU A 1 369 ? -4.19400 10.15200  21.72700 1.000 141.96621 ? 369 GLU A HB3  1 
ATOM   5186 H  HG2  . GLU A 1 369 ? -2.79200 10.78800  19.93000 1.000 140.22664 ? 369 GLU A HG2  1 
ATOM   5187 H  HG3  . GLU A 1 369 ? -2.86800 9.29200   19.40000 1.000 140.22664 ? 369 GLU A HG3  1 
ATOM   5188 N  N    . ALA A 1 370 ? -1.84000 9.38000   24.51600 1.000 123.31928 ? 370 ALA A N    1 
ATOM   5189 C  CA   . ALA A 1 370 ? -2.12300 9.31100   25.93900 1.000 133.93484 ? 370 ALA A CA   1 
ATOM   5190 C  C    . ALA A 1 370 ? -2.62000 10.66600  26.43300 1.000 137.01539 ? 370 ALA A C    1 
ATOM   5191 O  O    . ALA A 1 370 ? -2.19000 11.71000  25.93200 1.000 126.92664 ? 370 ALA A O    1 
ATOM   5192 C  CB   . ALA A 1 370 ? -0.87400 8.90700   26.72600 1.000 113.02335 ? 370 ALA A CB   1 
ATOM   5193 H  H    . ALA A 1 370 ? -1.08400 9.75400   24.34600 1.000 147.92290 ? 370 ALA A H    1 
ATOM   5194 H  HA   . ALA A 1 370 ? -2.80500 8.64300   26.11000 1.000 160.66157 ? 370 ALA A HA   1 
ATOM   5195 H  HB1  . ALA A 1 370 ? -1.09500 8.86700   27.66900 1.000 135.56778 ? 370 ALA A HB1  1 
ATOM   5196 H  HB2  . ALA A 1 370 ? -0.57500 8.03700   26.41800 1.000 135.56778 ? 370 ALA A HB2  1 
ATOM   5197 H  HB3  . ALA A 1 370 ? -0.17900 9.56700   26.57700 1.000 135.56778 ? 370 ALA A HB3  1 
ATOM   5198 N  N    . PRO A 1 371 ? -3.52500 10.69600  27.40700 1.000 149.66428 ? 371 PRO A N    1 
ATOM   5199 C  CA   . PRO A 1 371 ? -4.12200 11.97300  27.83000 1.000 151.03711 ? 371 PRO A CA   1 
ATOM   5200 C  C    . PRO A 1 371 ? -3.06100 12.95900  28.28400 1.000 140.50072 ? 371 PRO A C    1 
ATOM   5201 O  O    . PRO A 1 371 ? -2.19600 12.61900  29.10500 1.000 137.35830 ? 371 PRO A O    1 
ATOM   5202 C  CB   . PRO A 1 371 ? -5.04600 11.56900  28.99200 1.000 161.59685 ? 371 PRO A CB   1 
ATOM   5203 C  CG   . PRO A 1 371 ? -4.60300 10.19700  29.39800 1.000 160.78688 ? 371 PRO A CG   1 
ATOM   5204 C  CD   . PRO A 1 371 ? -4.08000 9.55600   28.15700 1.000 152.21195 ? 371 PRO A CD   1 
ATOM   5205 H  HA   . PRO A 1 371 ? -4.64300 12.36300  27.11100 1.000 181.18430 ? 371 PRO A HA   1 
ATOM   5206 H  HB2  . PRO A 1 371 ? -4.94400 12.19500  29.72500 1.000 193.85599 ? 371 PRO A HB2  1 
ATOM   5207 H  HB3  . PRO A 1 371 ? -5.96800 11.55900  28.69000 1.000 193.85599 ? 371 PRO A HB3  1 
ATOM   5208 H  HG2  . PRO A 1 371 ? -3.90700 10.26300  30.07100 1.000 192.88401 ? 371 PRO A HG2  1 
ATOM   5209 H  HG3  . PRO A 1 371 ? -5.35800 9.70000   29.75000 1.000 192.88401 ? 371 PRO A HG3  1 
ATOM   5210 H  HD2  . PRO A 1 371 ? -3.38900 8.90800   28.36500 1.000 182.59410 ? 371 PRO A HD2  1 
ATOM   5211 H  HD3  . PRO A 1 371 ? -4.79500 9.12900   27.65900 1.000 182.59410 ? 371 PRO A HD3  1 
ATOM   5212 N  N    . PRO A 1 372 ? -3.08600 14.18800  27.77200 1.000 127.35946 ? 372 PRO A N    1 
ATOM   5213 C  CA   . PRO A 1 372 ? -2.14200 15.21000  28.24300 1.000 117.54159 ? 372 PRO A CA   1 
ATOM   5214 C  C    . PRO A 1 372 ? -2.59000 15.79800  29.56900 1.000 125.01742 ? 372 PRO A C    1 
ATOM   5215 O  O    . PRO A 1 372 ? -3.68100 15.47400  30.06200 1.000 123.06330 ? 372 PRO A O    1 
ATOM   5216 C  CB   . PRO A 1 372 ? -2.17200 16.26100  27.12200 1.000 97.97294  ? 372 PRO A CB   1 
ATOM   5217 C  CG   . PRO A 1 372 ? -3.50900 16.11200  26.50300 1.000 100.18514 ? 372 PRO A CG   1 
ATOM   5218 C  CD   . PRO A 1 372 ? -3.89600 14.66700  26.63500 1.000 115.32821 ? 372 PRO A CD   1 
ATOM   5219 H  HA   . PRO A 1 372 ? -1.24600 14.84700  28.33000 1.000 140.98966 ? 372 PRO A HA   1 
ATOM   5220 H  HB2  . PRO A 1 372 ? -2.05900 17.14800  27.49700 1.000 117.50729 ? 372 PRO A HB2  1 
ATOM   5221 H  HB3  . PRO A 1 372 ? -1.46900 16.08000  26.47900 1.000 117.50729 ? 372 PRO A HB3  1 
ATOM   5222 H  HG2  . PRO A 1 372 ? -4.14500 16.67800  26.96800 1.000 120.16193 ? 372 PRO A HG2  1 
ATOM   5223 H  HG3  . PRO A 1 372 ? -3.46200 16.36700  25.56800 1.000 120.16193 ? 372 PRO A HG3  1 
ATOM   5224 H  HD2  . PRO A 1 372 ? -4.84300 14.58100  26.82800 1.000 138.33362 ? 372 PRO A HD2  1 
ATOM   5225 H  HD3  . PRO A 1 372 ? -3.67700 14.17700  25.82700 1.000 138.33362 ? 372 PRO A HD3  1 
ATOM   5226 N  N    . PRO A 1 373 ? -1.77300 16.66800  30.18900 1.000 127.91340 ? 373 PRO A N    1 
ATOM   5227 C  CA   . PRO A 1 373 ? -2.14000 17.27400  31.47600 1.000 122.82663 ? 373 PRO A CA   1 
ATOM   5228 C  C    . PRO A 1 373 ? -3.45200 18.05200  31.42400 1.000 114.29175 ? 373 PRO A C    1 
ATOM   5229 O  O    . PRO A 1 373 ? -3.73300 18.80600  32.35700 1.000 101.47051 ? 373 PRO A O    1 
ATOM   5230 C  CB   . PRO A 1 373 ? -0.96300 18.21800  31.77200 1.000 120.69894 ? 373 PRO A CB   1 
ATOM   5231 C  CG   . PRO A 1 373 ? -0.25200 18.39000  30.46700 1.000 97.52319  ? 373 PRO A CG   1 
ATOM   5232 C  CD   . PRO A 1 373 ? -0.43200 17.09200  29.75300 1.000 115.52554 ? 373 PRO A CD   1 
ATOM   5233 H  HA   . PRO A 1 373 ? -2.20000 16.59300  32.16400 1.000 147.33172 ? 373 PRO A HA   1 
ATOM   5234 H  HB2  . PRO A 1 373 ? -1.29800 19.06800  32.09800 1.000 144.77849 ? 373 PRO A HB2  1 
ATOM   5235 H  HB3  . PRO A 1 373 ? -0.37800 17.81600  32.43400 1.000 144.77849 ? 373 PRO A HB3  1 
ATOM   5236 H  HG2  . PRO A 1 373 ? -0.65200 19.11900  29.96600 1.000 116.96759 ? 373 PRO A HG2  1 
ATOM   5237 H  HG3  . PRO A 1 373 ? 0.68700  18.57200  30.62300 1.000 116.96759 ? 373 PRO A HG3  1 
ATOM   5238 H  HD2  . PRO A 1 373 ? -0.40100 17.21600  28.79200 1.000 138.57041 ? 373 PRO A HD2  1 
ATOM   5239 H  HD3  . PRO A 1 373 ? 0.24200  16.44900  30.02600 1.000 138.57041 ? 373 PRO A HD3  1 
ATOM   5240 N  N    . GLN A 1 379 ? 4.24900  26.42700  38.20200 1.000 76.65602  ? 379 GLN A N    1 
ATOM   5241 C  CA   . GLN A 1 379 ? 3.54000  26.36700  36.93000 1.000 84.61743  ? 379 GLN A CA   1 
ATOM   5242 C  C    . GLN A 1 379 ? 4.02000  27.46700  35.98800 1.000 86.46094  ? 379 GLN A C    1 
ATOM   5243 O  O    . GLN A 1 379 ? 4.81200  28.32600  36.37500 1.000 81.47820  ? 379 GLN A O    1 
ATOM   5244 C  CB   . GLN A 1 379 ? 2.03000  26.48900  37.15100 1.000 85.31327  ? 379 GLN A CB   1 
ATOM   5245 H  HA   . GLN A 1 379 ? 3.71400  25.51000  36.51000 1.000 101.48068 ? 379 GLN A HA   1 
ATOM   5246 N  N    . LEU A 1 380 ? 3.53500  27.42500  34.74600 1.000 94.20065  ? 380 LEU A N    1 
ATOM   5247 C  CA   . LEU A 1 380 ? 3.84900  28.43900  33.74600 1.000 106.33655 ? 380 LEU A CA   1 
ATOM   5248 C  C    . LEU A 1 380 ? 5.35000  28.54000  33.49400 1.000 102.71972 ? 380 LEU A C    1 
ATOM   5249 O  O    . LEU A 1 380 ? 6.15700  27.99900  34.25700 1.000 94.21066  ? 380 LEU A O    1 
ATOM   5250 C  CB   . LEU A 1 380 ? 3.29600  29.80200  34.17800 1.000 110.85219 ? 380 LEU A CB   1 
ATOM   5251 C  CG   . LEU A 1 380 ? 1.78500  30.02700  34.05200 1.000 112.46096 ? 380 LEU A CG   1 
ATOM   5252 C  CD1  . LEU A 1 380 ? 1.44100  31.48800  34.31700 1.000 107.27560 ? 380 LEU A CD1  1 
ATOM   5253 C  CD2  . LEU A 1 380 ? 1.25900  29.60000  32.68800 1.000 102.14789 ? 380 LEU A CD2  1 
ATOM   5254 H  H    . LEU A 1 380 ? 3.01200  26.80700  34.45500 1.000 112.98054 ? 380 LEU A H    1 
ATOM   5255 H  HA   . LEU A 1 380 ? 3.42800  28.18200  32.91000 1.000 127.54362 ? 380 LEU A HA   1 
ATOM   5256 H  HB2  . LEU A 1 380 ? 3.52200  29.93100  35.11300 1.000 132.96240 ? 380 LEU A HB2  1 
ATOM   5257 H  HB3  . LEU A 1 380 ? 3.72700  30.48200  33.63600 1.000 132.96240 ? 380 LEU A HB3  1 
ATOM   5258 H  HG   . LEU A 1 380 ? 1.34300  29.47600  34.71600 1.000 134.89292 ? 380 LEU A HG   1 
ATOM   5259 H  HD11 . LEU A 1 380 ? 0.48000  31.60300  34.25400 1.000 128.67048 ? 380 LEU A HD11 1 
ATOM   5260 H  HD12 . LEU A 1 380 ? 1.74500  31.72800  35.20600 1.000 128.67048 ? 380 LEU A HD12 1 
ATOM   5261 H  HD13 . LEU A 1 380 ? 1.88400  32.04200  33.65500 1.000 128.67048 ? 380 LEU A HD13 1 
ATOM   5262 H  HD21 . LEU A 1 380 ? 0.36700  29.96300  32.56600 1.000 122.51723 ? 380 LEU A HD21 1 
ATOM   5263 H  HD22 . LEU A 1 380 ? 1.85200  29.94100  32.00000 1.000 122.51723 ? 380 LEU A HD22 1 
ATOM   5264 H  HD23 . LEU A 1 380 ? 1.22900  28.63200  32.65000 1.000 122.51723 ? 380 LEU A HD23 1 
ATOM   5265 N  N    . ASP A 1 381 ? 5.72900  29.22200  32.41700 1.000 99.76924  ? 381 ASP A N    1 
ATOM   5266 C  CA   . ASP A 1 381 ? 7.12500  29.50300  32.10800 1.000 101.84760 ? 381 ASP A CA   1 
ATOM   5267 C  C    . ASP A 1 381 ? 7.41700  30.95000  32.47800 1.000 94.54127  ? 381 ASP A C    1 
ATOM   5268 O  O    . ASP A 1 381 ? 6.72100  31.86300  32.02200 1.000 94.11468  ? 381 ASP A O    1 
ATOM   5269 C  CB   . ASP A 1 381 ? 7.42100  29.26200  30.62800 1.000 103.59429 ? 381 ASP A CB   1 
ATOM   5270 C  CG   . ASP A 1 381 ? 8.77300  29.80800  30.20800 1.000 99.87643  ? 381 ASP A CG   1 
ATOM   5271 O  OD1  . ASP A 1 381 ? 9.72700  29.71800  31.00900 1.000 110.80024 ? 381 ASP A OD1  1 
ATOM   5272 O  OD2  . ASP A 1 381 ? 8.88100  30.32800  29.07800 1.000 94.89621  ? 381 ASP A OD2  1 
ATOM   5273 H  H    . ASP A 1 381 ? 5.18100  29.53900  31.83600 1.000 119.66285 ? 381 ASP A H    1 
ATOM   5274 H  HA   . ASP A 1 381 ? 7.70400  28.92000  32.62200 1.000 122.15688 ? 381 ASP A HA   1 
ATOM   5275 H  HB2  . ASP A 1 381 ? 7.41600  28.30700  30.45500 1.000 124.25291 ? 381 ASP A HB2  1 
ATOM   5276 H  HB3  . ASP A 1 381 ? 6.74100  29.70000  30.09300 1.000 124.25291 ? 381 ASP A HB3  1 
ATOM   5277 N  N    . GLU A 1 382 ? 8.44300  31.15700  33.29800 1.000 86.86848  ? 382 GLU A N    1 
ATOM   5278 C  CA   . GLU A 1 382 ? 8.67300  32.45500  33.90700 1.000 93.81045  ? 382 GLU A CA   1 
ATOM   5279 C  C    . GLU A 1 382 ? 9.76800  33.22900  33.18100 1.000 92.36476  ? 382 GLU A C    1 
ATOM   5280 O  O    . GLU A 1 382 ? 10.40300 32.75300  32.23300 1.000 83.95690  ? 382 GLU A O    1 
ATOM   5281 C  CB   . GLU A 1 382 ? 8.99800  32.28600  35.39300 1.000 83.05962  ? 382 GLU A CB   1 
ATOM   5282 C  CG   . GLU A 1 382 ? 7.86200  31.64500  36.17900 1.000 87.58281  ? 382 GLU A CG   1 
ATOM   5283 C  CD   . GLU A 1 382 ? 8.11400  31.63000  37.67100 1.000 97.68581  ? 382 GLU A CD   1 
ATOM   5284 O  OE1  . GLU A 1 382 ? 9.29500  31.64600  38.07200 1.000 99.45693  ? 382 GLU A OE1  1 
ATOM   5285 O  OE2  . GLU A 1 382 ? 7.13200  31.60800  38.44300 1.000 89.63061  ? 382 GLU A OE2  1 
ATOM   5286 H  H    . GLU A 1 382 ? 9.01900  30.55700  33.51500 1.000 104.18194 ? 382 GLU A H    1 
ATOM   5287 H  HA   . GLU A 1 382 ? 7.85900  32.97600  33.82200 1.000 112.51230 ? 382 GLU A HA   1 
ATOM   5288 H  HB2  . GLU A 1 382 ? 9.78000  31.72000  35.48200 1.000 99.61130  ? 382 GLU A HB2  1 
ATOM   5289 H  HB3  . GLU A 1 382 ? 9.17300  33.15800  35.77800 1.000 99.61130  ? 382 GLU A HB3  1 
ATOM   5290 H  HG2  . GLU A 1 382 ? 7.04600  32.14400  36.01800 1.000 105.03913 ? 382 GLU A HG2  1 
ATOM   5291 H  HG3  . GLU A 1 382 ? 7.75300  30.72700  35.88400 1.000 105.03913 ? 382 GLU A HG3  1 
ATOM   5292 N  N    . ARG A 1 383 ? 9.99900  34.45400  33.66000 1.000 90.21835  ? 383 ARG A N    1 
ATOM   5293 C  CA   . ARG A 1 383 ? 10.74100 35.49800  32.96700 1.000 78.12616  ? 383 ARG A CA   1 
ATOM   5294 C  C    . ARG A 1 383 ? 12.14100 35.66300  33.57700 1.000 68.37581  ? 383 ARG A C    1 
ATOM   5295 O  O    . ARG A 1 383 ? 12.71800 34.69500  34.07800 1.000 67.93465  ? 383 ARG A O    1 
ATOM   5296 C  CB   . ARG A 1 383 ? 9.94400  36.79500  33.00300 1.000 82.82307  ? 383 ARG A CB   1 
ATOM   5297 C  CG   . ARG A 1 383 ? 9.79500  37.44800  34.39800 1.000 68.22324  ? 383 ARG A CG   1 
ATOM   5298 C  CD   . ARG A 1 383 ? 8.68200  36.77900  35.20300 1.000 77.31784  ? 383 ARG A CD   1 
ATOM   5299 N  NE   . ARG A 1 383 ? 8.31400  37.49000  36.42200 1.000 88.50599  ? 383 ARG A NE   1 
ATOM   5300 C  CZ   . ARG A 1 383 ? 7.52200  36.98700  37.36100 1.000 87.10837  ? 383 ARG A CZ   1 
ATOM   5301 N  NH1  . ARG A 1 383 ? 7.00000  35.77600  37.24800 1.000 89.34252  ? 383 ARG A NH1  1 
ATOM   5302 N  NH2  . ARG A 1 383 ? 7.25100  37.71400  38.44100 1.000 77.50517  ? 383 ARG A NH2  1 
ATOM   5303 H  H    . ARG A 1 383 ? 9.71700  34.71200  34.43100 1.000 108.20178 ? 383 ARG A H    1 
ATOM   5304 H  HA   . ARG A 1 383 ? 10.83800 35.20400  32.04800 1.000 93.69115  ? 383 ARG A HA   1 
ATOM   5305 H  HB2  . ARG A 1 383 ? 10.38500 37.44000  32.42800 1.000 99.32745  ? 383 ARG A HB2  1 
ATOM   5306 H  HB3  . ARG A 1 383 ? 9.05000  36.61300  32.67300 1.000 99.32745  ? 383 ARG A HB3  1 
ATOM   5307 H  HG2  . ARG A 1 383 ? 10.62700 37.35500  34.88900 1.000 81.80765  ? 383 ARG A HG2  1 
ATOM   5308 H  HG3  . ARG A 1 383 ? 9.57500  38.38700  34.29400 1.000 81.80765  ? 383 ARG A HG3  1 
ATOM   5309 H  HD2  . ARG A 1 383 ? 7.89000  36.72000  34.64700 1.000 92.72117  ? 383 ARG A HD2  1 
ATOM   5310 H  HD3  . ARG A 1 383 ? 8.97500  35.89100  35.45900 1.000 92.72117  ? 383 ARG A HD3  1 
ATOM   5311 H  HE   . ARG A 1 383 ? 8.62800  38.28200  36.54000 1.000 106.14695 ? 383 ARG A HE   1 
ATOM   5312 H  HH11 . ARG A 1 383 ? 7.17200  35.29700  36.55500 1.000 107.15079 ? 383 ARG A HH11 1 
ATOM   5313 H  HH12 . ARG A 1 383 ? 6.48900  35.46900  37.86800 1.000 107.15079 ? 383 ARG A HH12 1 
ATOM   5314 H  HH21 . ARG A 1 383 ? 7.58700  38.50100  38.52500 1.000 92.94596  ? 383 ARG A HH21 1 
ATOM   5315 H  HH22 . ARG A 1 383 ? 6.73900  37.39800  39.05500 1.000 92.94596  ? 383 ARG A HH22 1 
ATOM   5316 N  N    . GLU A 1 384 ? 12.66600 36.88500  33.52800 1.000 67.15119  ? 384 GLU A N    1 
ATOM   5317 C  CA   . GLU A 1 384 ? 13.98000 37.14800  34.10600 1.000 68.42729  ? 384 GLU A CA   1 
ATOM   5318 C  C    . GLU A 1 384 ? 13.86200 37.40500  35.60400 1.000 69.74220  ? 384 GLU A C    1 
ATOM   5319 O  O    . GLU A 1 384 ? 12.99900 38.16600  36.05400 1.000 73.52780  ? 384 GLU A O    1 
ATOM   5320 C  CB   . GLU A 1 384 ? 14.64800 38.33500  33.41600 1.000 75.29407  ? 384 GLU A CB   1 
ATOM   5321 C  CG   . GLU A 1 384 ? 16.16000 38.18400  33.29900 1.000 77.65659  ? 384 GLU A CG   1 
ATOM   5322 C  CD   . GLU A 1 384 ? 16.60200 37.58800  31.97300 1.000 85.29415  ? 384 GLU A CD   1 
ATOM   5323 O  OE1  . GLU A 1 384 ? 15.74100 37.08200  31.22300 1.000 97.58048  ? 384 GLU A OE1  1 
ATOM   5324 O  OE2  . GLU A 1 384 ? 17.81700 37.61900  31.68500 1.000 75.47733  ? 384 GLU A OE2  1 
ATOM   5325 H  H    . GLU A 1 384 ? 12.28600 37.56800  33.17100 1.000 80.52119  ? 384 GLU A H    1 
ATOM   5326 H  HA   . GLU A 1 384 ? 14.54100 36.36800  33.97600 1.000 82.05251  ? 384 GLU A HA   1 
ATOM   5327 H  HB2  . GLU A 1 384 ? 14.28600 38.42200  32.52000 1.000 90.29264  ? 384 GLU A HB2  1 
ATOM   5328 H  HB3  . GLU A 1 384 ? 14.46600 39.13900  33.92700 1.000 90.29264  ? 384 GLU A HB3  1 
ATOM   5329 H  HG2  . GLU A 1 384 ? 16.57100 39.05900  33.38400 1.000 93.12767  ? 384 GLU A HG2  1 
ATOM   5330 H  HG3  . GLU A 1 384 ? 16.47400 37.60000  34.00700 1.000 93.12767  ? 384 GLU A HG3  1 
ATOM   5331 N  N    . HIS A 1 385 ? 14.74100 36.75900  36.36600 1.000 65.99152  ? 385 HIS A N    1 
ATOM   5332 C  CA   . HIS A 1 385 ? 14.77400 36.84800  37.81500 1.000 48.09238  ? 385 HIS A CA   1 
ATOM   5333 C  C    . HIS A 1 385 ? 16.22400 36.95800  38.26500 1.000 47.26887  ? 385 HIS A C    1 
ATOM   5334 O  O    . HIS A 1 385 ? 17.15300 36.64800  37.51500 1.000 48.61952  ? 385 HIS A O    1 
ATOM   5335 C  CB   . HIS A 1 385 ? 14.11500 35.62300  38.45700 1.000 50.80763  ? 385 HIS A CB   1 
ATOM   5336 C  CG   . HIS A 1 385 ? 12.62700 35.59300  38.31600 1.000 56.89680  ? 385 HIS A CG   1 
ATOM   5337 N  ND1  . HIS A 1 385 ? 11.95700 34.54500  37.72400 1.000 59.60642  ? 385 HIS A ND1  1 
ATOM   5338 C  CD2  . HIS A 1 385 ? 11.67700 36.48000  38.69700 1.000 57.56307  ? 385 HIS A CD2  1 
ATOM   5339 C  CE1  . HIS A 1 385 ? 10.65900 34.79000  37.74000 1.000 71.88592  ? 385 HIS A CE1  1 
ATOM   5340 N  NE2  . HIS A 1 385 ? 10.46300 35.95700  38.32600 1.000 70.00294  ? 385 HIS A NE2  1 
ATOM   5341 H  H    . HIS A 1 385 ? 15.35200 36.24300  36.05100 1.000 79.12958  ? 385 HIS A H    1 
ATOM   5342 H  HA   . HIS A 1 385 ? 14.30100 37.64200  38.10900 1.000 57.65061  ? 385 HIS A HA   1 
ATOM   5343 H  HB2  . HIS A 1 385 ? 14.46800 34.82300  38.03600 1.000 60.90892  ? 385 HIS A HB2  1 
ATOM   5344 H  HB3  . HIS A 1 385 ? 14.32300 35.61800  39.40500 1.000 60.90892  ? 385 HIS A HB3  1 
ATOM   5345 H  HD1  . HIS A 1 385 ? 12.32600 33.84200  37.39500 1.000 71.46746  ? 385 HIS A HD1  1 
ATOM   5346 H  HD2  . HIS A 1 385 ? 11.82100 37.29100  39.12900 1.000 69.01545  ? 385 HIS A HD2  1 
ATOM   5347 H  HE1  . HIS A 1 385 ? 9.99600  34.23500  37.39700 1.000 86.20287  ? 385 HIS A HE1  1 
ATOM   5348 N  N    . THR A 1 386 ? 16.40900 37.40000  39.50400 1.000 48.18729  ? 386 THR A N    1 
ATOM   5349 C  CA   . THR A 1 386 ? 17.73700 37.45800  40.08900 1.000 52.43380  ? 386 THR A CA   1 
ATOM   5350 C  C    . THR A 1 386 ? 18.18900 36.06300  40.52100 1.000 49.12644  ? 386 THR A C    1 
ATOM   5351 O  O    . THR A 1 386 ? 17.42300 35.09700  40.50300 1.000 44.88015  ? 386 THR A O    1 
ATOM   5352 C  CB   . THR A 1 386 ? 17.75500 38.39700  41.29000 1.000 33.41432  ? 386 THR A CB   1 
ATOM   5353 O  OG1  . THR A 1 386 ? 16.65500 38.08400  42.15500 1.000 49.47847  ? 386 THR A OG1  1 
ATOM   5354 C  CG2  . THR A 1 386 ? 17.64800 39.85200  40.84100 1.000 52.60619  ? 386 THR A CG2  1 
ATOM   5355 H  H    . THR A 1 386 ? 15.78100 37.67100  40.02500 1.000 57.76451  ? 386 THR A H    1 
ATOM   5356 H  HA   . THR A 1 386 ? 18.35700 37.79700  39.42400 1.000 62.86032  ? 386 THR A HA   1 
ATOM   5357 H  HB   . THR A 1 386 ? 18.58900 38.29100  41.77300 1.000 40.03694  ? 386 THR A HB   1 
ATOM   5358 H  HG1  . THR A 1 386 ? 16.66100 38.59200  42.82400 1.000 59.31392  ? 386 THR A HG1  1 
ATOM   5359 H  HG21 . THR A 1 386 ? 17.66100 40.44000  41.61300 1.000 63.06718  ? 386 THR A HG21 1 
ATOM   5360 H  HG22 . THR A 1 386 ? 18.39300 40.07600  40.26200 1.000 63.06718  ? 386 THR A HG22 1 
ATOM   5361 H  HG23 . THR A 1 386 ? 16.82000 39.99000  40.35500 1.000 63.06718  ? 386 THR A HG23 1 
ATOM   5362 N  N    . ILE A 1 387 ? 19.46200 35.96800  40.91300 1.000 41.42232  ? 387 ILE A N    1 
ATOM   5363 C  CA   . ILE A 1 387 ? 19.95700 34.74500  41.53800 1.000 49.23341  ? 387 ILE A CA   1 
ATOM   5364 C  C    . ILE A 1 387 ? 19.09700 34.39400  42.74200 1.000 41.39203  ? 387 ILE A C    1 
ATOM   5365 O  O    . ILE A 1 387 ? 18.63300 33.25700  42.89700 1.000 35.43892  ? 387 ILE A O    1 
ATOM   5366 C  CB   . ILE A 1 387 ? 21.43400 34.91200  41.94200 1.000 43.38285  ? 387 ILE A CB   1 
ATOM   5367 C  CG1  . ILE A 1 387 ? 22.24700 35.47800  40.77900 1.000 44.83566  ? 387 ILE A CG1  1 
ATOM   5368 C  CG2  . ILE A 1 387 ? 22.02300 33.57500  42.39800 1.000 52.42764  ? 387 ILE A CG2  1 
ATOM   5369 C  CD1  . ILE A 1 387 ? 23.71900 35.14300  40.85800 1.000 48.75485  ? 387 ILE A CD1  1 
ATOM   5370 H  H    . ILE A 1 387 ? 20.05000 36.59100  40.83000 1.000 49.64654  ? 387 ILE A H    1 
ATOM   5371 H  HA   . ILE A 1 387 ? 19.89900 34.02100  40.89500 1.000 59.01985  ? 387 ILE A HA   1 
ATOM   5372 H  HB   . ILE A 1 387 ? 21.47300 35.53800  42.68200 1.000 51.99918  ? 387 ILE A HB   1 
ATOM   5373 H  HG12 . ILE A 1 387 ? 21.90300 35.11300  39.94900 1.000 53.74255  ? 387 ILE A HG12 1 
ATOM   5374 H  HG13 . ILE A 1 387 ? 22.16100 36.44400  40.77700 1.000 53.74255  ? 387 ILE A HG13 1 
ATOM   5375 H  HG21 . ILE A 1 387 ? 22.95400 33.70500  42.63700 1.000 62.85293  ? 387 ILE A HG21 1 
ATOM   5376 H  HG22 . ILE A 1 387 ? 21.52600 33.25600  43.16800 1.000 62.85293  ? 387 ILE A HG22 1 
ATOM   5377 H  HG23 . ILE A 1 387 ? 21.95400 32.93500  41.67200 1.000 62.85293  ? 387 ILE A HG23 1 
ATOM   5378 H  HD11 . ILE A 1 387 ? 24.17000 35.51900  40.08500 1.000 58.44558  ? 387 ILE A HD11 1 
ATOM   5379 H  HD12 . ILE A 1 387 ? 24.08600 35.52300  41.67200 1.000 58.44558  ? 387 ILE A HD12 1 
ATOM   5380 H  HD13 . ILE A 1 387 ? 23.82300 34.17900  40.86600 1.000 58.44558  ? 387 ILE A HD13 1 
ATOM   5381 N  N    . GLU A 1 388 ? 18.87300 35.37700  43.61500 1.000 41.12654  ? 388 GLU A N    1 
ATOM   5382 C  CA   . GLU A 1 388 ? 18.09400 35.15300  44.82600 1.000 31.85018  ? 388 GLU A CA   1 
ATOM   5383 C  C    . GLU A 1 388 ? 16.70000 34.63400  44.50200 1.000 34.65543  ? 388 GLU A C    1 
ATOM   5384 O  O    . GLU A 1 388 ? 16.20400 33.71100  45.16100 1.000 41.24141  ? 388 GLU A O    1 
ATOM   5385 C  CB   . GLU A 1 388 ? 18.01200 36.45700  45.62400 1.000 58.43513  ? 388 GLU A CB   1 
ATOM   5386 C  CG   . GLU A 1 388 ? 16.97100 36.47000  46.73600 1.000 69.55406  ? 388 GLU A CG   1 
ATOM   5387 C  CD   . GLU A 1 388 ? 15.82400 37.42900  46.46100 1.000 78.02174  ? 388 GLU A CD   1 
ATOM   5388 O  OE1  . GLU A 1 388 ? 16.07000 38.51900  45.89900 1.000 65.76883  ? 388 GLU A OE1  1 
ATOM   5389 O  OE2  . GLU A 1 388 ? 14.67300 37.09300  46.81100 1.000 76.80313  ? 388 GLU A OE2  1 
ATOM   5390 H  H    . GLU A 1 388 ? 19.16100 36.18200  43.52800 1.000 49.29161  ? 388 GLU A H    1 
ATOM   5391 H  HA   . GLU A 1 388 ? 18.53700 34.48400  45.37100 1.000 38.15997  ? 388 GLU A HA   1 
ATOM   5392 H  HB2  . GLU A 1 388 ? 18.87600 36.62000  46.03300 1.000 70.06192  ? 388 GLU A HB2  1 
ATOM   5393 H  HB3  . GLU A 1 388 ? 17.79300 37.17700  45.01200 1.000 70.06192  ? 388 GLU A HB3  1 
ATOM   5394 H  HG2  . GLU A 1 388 ? 16.60000 35.57900  46.83200 1.000 83.40463  ? 388 GLU A HG2  1 
ATOM   5395 H  HG3  . GLU A 1 388 ? 17.39700 36.74300  47.56400 1.000 83.40463  ? 388 GLU A HG3  1 
ATOM   5396 N  N    . GLU A 1 389 ? 16.04800 35.21900  43.49700 1.000 38.55957  ? 389 GLU A N    1 
ATOM   5397 C  CA   . GLU A 1 389 ? 14.68600 34.81700  43.16800 1.000 37.16845  ? 389 GLU A CA   1 
ATOM   5398 C  C    . GLU A 1 389 ? 14.65000 33.40700  42.59000 1.000 33.73993  ? 389 GLU A C    1 
ATOM   5399 O  O    . GLU A 1 389 ? 13.77700 32.60700  42.94600 1.000 32.20676  ? 389 GLU A O    1 
ATOM   5400 C  CB   . GLU A 1 389 ? 14.07600 35.82300  42.19300 1.000 38.87504  ? 389 GLU A CB   1 
ATOM   5401 C  CG   . GLU A 1 389 ? 13.54000 37.07800  42.86900 1.000 46.39074  ? 389 GLU A CG   1 
ATOM   5402 C  CD   . GLU A 1 389 ? 13.43900 38.25700  41.92100 1.000 49.52965  ? 389 GLU A CD   1 
ATOM   5403 O  OE1  . GLU A 1 389 ? 13.63200 38.06300  40.70300 1.000 51.75952  ? 389 GLU A OE1  1 
ATOM   5404 O  OE2  . GLU A 1 389 ? 13.16700 39.37900  42.39500 1.000 59.78987  ? 389 GLU A OE2  1 
ATOM   5405 H  H    . GLU A 1 389 ? 16.36900 35.84300  42.99900 1.000 46.21124  ? 389 GLU A H    1 
ATOM   5406 H  HA   . GLU A 1 389 ? 14.14900 34.81700  43.97500 1.000 44.54190  ? 389 GLU A HA   1 
ATOM   5407 H  HB2  . GLU A 1 389 ? 14.75700 36.09500  41.55800 1.000 46.58981  ? 389 GLU A HB2  1 
ATOM   5408 H  HB3  . GLU A 1 389 ? 13.33900 35.39800  41.72700 1.000 46.58981  ? 389 GLU A HB3  1 
ATOM   5409 H  HG2  . GLU A 1 389 ? 12.65300 36.89500  43.21600 1.000 55.60865  ? 389 GLU A HG2  1 
ATOM   5410 H  HG3  . GLU A 1 389 ? 14.13500 37.32600  43.59400 1.000 55.60865  ? 389 GLU A HG3  1 
ATOM   5411 N  N    . TRP A 1 390 ? 15.58900 33.08500  41.69500 1.000 33.19649  ? 390 TRP A N    1 
ATOM   5412 C  CA   . TRP A 1 390 ? 15.65800 31.73600  41.14000 1.000 32.52941  ? 390 TRP A CA   1 
ATOM   5413 C  C    . TRP A 1 390 ? 15.87100 30.70300  42.24000 1.000 32.44307  ? 390 TRP A C    1 
ATOM   5414 O  O    . TRP A 1 390 ? 15.22700 29.64700  42.25400 1.000 35.40218  ? 390 TRP A O    1 
ATOM   5415 C  CB   . TRP A 1 390 ? 16.79000 31.64900  40.11900 1.000 28.70091  ? 390 TRP A CB   1 
ATOM   5416 C  CG   . TRP A 1 390 ? 16.44100 32.16500  38.76200 1.000 31.18856  ? 390 TRP A CG   1 
ATOM   5417 C  CD1  . TRP A 1 390 ? 17.07600 33.16000  38.08100 1.000 39.61458  ? 390 TRP A CD1  1 
ATOM   5418 C  CD2  . TRP A 1 390 ? 15.38200 31.70700  37.91100 1.000 37.11052  ? 390 TRP A CD2  1 
ATOM   5419 N  NE1  . TRP A 1 390 ? 16.47900 33.35200  36.85900 1.000 41.65249  ? 390 TRP A NE1  1 
ATOM   5420 C  CE2  . TRP A 1 390 ? 15.43500 32.47500  36.73100 1.000 41.27555  ? 390 TRP A CE2  1 
ATOM   5421 C  CE3  . TRP A 1 390 ? 14.39400 30.72500  38.03200 1.000 40.11698  ? 390 TRP A CE3  1 
ATOM   5422 C  CZ2  . TRP A 1 390 ? 14.54000 32.29200  35.68000 1.000 46.45616  ? 390 TRP A CZ2  1 
ATOM   5423 C  CZ3  . TRP A 1 390 ? 13.50500 30.54500  36.98600 1.000 42.01427  ? 390 TRP A CZ3  1 
ATOM   5424 C  CH2  . TRP A 1 390 ? 13.58400 31.32500  35.82500 1.000 42.81718  ? 390 TRP A CH2  1 
ATOM   5425 H  H    . TRP A 1 390 ? 16.19000 33.62400  41.39800 1.000 39.77555  ? 390 TRP A H    1 
ATOM   5426 H  HA   . TRP A 1 390 ? 14.82100 31.54300  40.69000 1.000 38.97505  ? 390 TRP A HA   1 
ATOM   5427 H  HB2  . TRP A 1 390 ? 17.54200 32.16800  40.44500 1.000 34.38085  ? 390 TRP A HB2  1 
ATOM   5428 H  HB3  . TRP A 1 390 ? 17.04700 30.71800  40.02100 1.000 34.38085  ? 390 TRP A HB3  1 
ATOM   5429 H  HD1  . TRP A 1 390 ? 17.80700 33.63800  38.39700 1.000 47.47726  ? 390 TRP A HD1  1 
ATOM   5430 H  HE1  . TRP A 1 390 ? 16.72200 33.93000  36.27000 1.000 49.92275  ? 390 TRP A HE1  1 
ATOM   5431 H  HE3  . TRP A 1 390 ? 14.33500 30.20300  38.80000 1.000 48.08014  ? 390 TRP A HE3  1 
ATOM   5432 H  HZ2  . TRP A 1 390 ? 14.59100 32.80800  34.90800 1.000 55.68716  ? 390 TRP A HZ2  1 
ATOM   5433 H  HZ3  . TRP A 1 390 ? 12.84300 29.89500  37.05500 1.000 50.35689  ? 390 TRP A HZ3  1 
ATOM   5434 H  HH2  . TRP A 1 390 ? 12.97400 31.18200  35.13900 1.000 51.32037  ? 390 TRP A HH2  1 
ATOM   5435 N  N    . LYS A 1 391 ? 16.79500 30.98700  43.16000 1.000 33.84606  ? 391 LYS A N    1 
ATOM   5436 C  CA   . LYS A 1 391 ? 17.06900 30.07000  44.26100 1.000 33.70822  ? 391 LYS A CA   1 
ATOM   5437 C  C    . LYS A 1 391 ? 15.78500 29.68300  44.98500 1.000 38.64638  ? 391 LYS A C    1 
ATOM   5438 O  O    . LYS A 1 391 ? 15.52700 28.50000  45.23300 1.000 31.93504  ? 391 LYS A O    1 
ATOM   5439 C  CB   . LYS A 1 391 ? 18.06400 30.71400  45.22800 1.000 31.63987  ? 391 LYS A CB   1 
ATOM   5440 C  CG   . LYS A 1 391 ? 18.52800 29.80700  46.35200 1.000 32.49001  ? 391 LYS A CG   1 
ATOM   5441 C  CD   . LYS A 1 391 ? 19.81300 30.32300  46.98600 1.000 43.15960  ? 391 LYS A CD   1 
ATOM   5442 C  CE   . LYS A 1 391 ? 19.82100 30.08700  48.48900 1.000 48.97390  ? 391 LYS A CE   1 
ATOM   5443 N  NZ   . LYS A 1 391 ? 21.19000 30.16800  49.07800 1.000 50.54728  ? 391 LYS A NZ   1 
ATOM   5444 H  H    . LYS A 1 391 ? 17.27500 31.70100  43.16700 1.000 40.55503  ? 391 LYS A H    1 
ATOM   5445 H  HA   . LYS A 1 391 ? 17.46800 29.25800  43.91000 1.000 40.38962  ? 391 LYS A HA   1 
ATOM   5446 H  HB2  . LYS A 1 391 ? 18.85000 30.98500  44.72700 1.000 37.90760  ? 391 LYS A HB2  1 
ATOM   5447 H  HB3  . LYS A 1 391 ? 17.64400 31.49000  45.63200 1.000 37.90760  ? 391 LYS A HB3  1 
ATOM   5448 H  HG2  . LYS A 1 391 ? 17.84300 29.76900  47.03800 1.000 38.92777  ? 391 LYS A HG2  1 
ATOM   5449 H  HG3  . LYS A 1 391 ? 18.69500 28.91900  46.00100 1.000 38.92777  ? 391 LYS A HG3  1 
ATOM   5450 H  HD2  . LYS A 1 391 ? 20.57200 29.85800  46.60000 1.000 51.73128  ? 391 LYS A HD2  1 
ATOM   5451 H  HD3  . LYS A 1 391 ? 19.89100 31.27600  46.82600 1.000 51.73128  ? 391 LYS A HD3  1 
ATOM   5452 H  HE2  . LYS A 1 391 ? 19.27000 30.76000  48.91800 1.000 58.70844  ? 391 LYS A HE2  1 
ATOM   5453 H  HE3  . LYS A 1 391 ? 19.46800 29.20200  48.67300 1.000 58.70844  ? 391 LYS A HE3  1 
ATOM   5454 H  HZ1  . LYS A 1 391 ? 21.15300 30.02600  49.95500 1.000 60.59650  ? 391 LYS A HZ1  1 
ATOM   5455 H  HZ2  . LYS A 1 391 ? 21.71700 29.55400  48.70700 1.000 60.59650  ? 391 LYS A HZ2  1 
ATOM   5456 H  HZ3  . LYS A 1 391 ? 21.53700 30.97400  48.93000 1.000 60.59650  ? 391 LYS A HZ3  1 
ATOM   5457 N  N    . GLU A 1 392 ? 14.95700 30.67500  45.31900 1.000 38.20856  ? 392 GLU A N    1 
ATOM   5458 C  CA   . GLU A 1 392 ? 13.72300 30.40000  46.04800 1.000 38.34425  ? 392 GLU A CA   1 
ATOM   5459 C  C    . GLU A 1 392 ? 12.71500 29.66100  45.17500 1.000 34.50777  ? 392 GLU A C    1 
ATOM   5460 O  O    . GLU A 1 392 ? 12.01400 28.76100  45.65300 1.000 44.10091  ? 392 GLU A O    1 
ATOM   5461 C  CB   . GLU A 1 392 ? 13.12400 31.70700  46.57100 1.000 41.01853  ? 392 GLU A CB   1 
ATOM   5462 C  CG   . GLU A 1 392 ? 11.86500 31.51900  47.39900 1.000 56.39959  ? 392 GLU A CG   1 
ATOM   5463 C  CD   . GLU A 1 392 ? 11.72100 32.54600  48.51100 1.000 66.95760  ? 392 GLU A CD   1 
ATOM   5464 O  OE1  . GLU A 1 392 ? 12.49300 33.52900  48.53000 1.000 67.44711  ? 392 GLU A OE1  1 
ATOM   5465 O  OE2  . GLU A 1 392 ? 10.83100 32.36800  49.36800 1.000 70.43022  ? 392 GLU A OE2  1 
ATOM   5466 H  H    . GLU A 1 392 ? 15.08600 31.50600  45.13700 1.000 45.79003  ? 392 GLU A H    1 
ATOM   5467 H  HA   . GLU A 1 392 ? 13.92900 29.83500  46.80900 1.000 45.95286  ? 392 GLU A HA   1 
ATOM   5468 H  HB2  . GLU A 1 392 ? 13.78200 32.15000  47.12900 1.000 49.16200  ? 392 GLU A HB2  1 
ATOM   5469 H  HB3  . GLU A 1 392 ? 12.89800 32.27100  45.81400 1.000 49.16200  ? 392 GLU A HB3  1 
ATOM   5470 H  HG2  . GLU A 1 392 ? 11.09200 31.59900  46.81900 1.000 67.61927  ? 392 GLU A HG2  1 
ATOM   5471 H  HG3  . GLU A 1 392 ? 11.88500 30.63900  47.80700 1.000 67.61927  ? 392 GLU A HG3  1 
ATOM   5472 N  N    . LEU A 1 393 ? 12.62300 30.02900  43.89500 1.000 37.57301  ? 393 LEU A N    1 
ATOM   5473 C  CA   . LEU A 1 393 ? 11.71200 29.33900  42.99000 1.000 35.38971  ? 393 LEU A CA   1 
ATOM   5474 C  C    . LEU A 1 393 ? 12.06600 27.86100  42.88800 1.000 38.91722  ? 393 LEU A C    1 
ATOM   5475 O  O    . LEU A 1 393 ? 11.19200 26.99100  42.96100 1.000 40.02216  ? 393 LEU A O    1 
ATOM   5476 C  CB   . LEU A 1 393 ? 11.76000 29.98700  41.60800 1.000 41.08088  ? 393 LEU A CB   1 
ATOM   5477 C  CG   . LEU A 1 393 ? 10.95100 31.26300  41.38600 1.000 48.16792  ? 393 LEU A CG   1 
ATOM   5478 C  CD1  . LEU A 1 393 ? 11.34400 31.86500  40.04700 1.000 51.55145  ? 393 LEU A CD1  1 
ATOM   5479 C  CD2  . LEU A 1 393 ? 9.45500  30.99600  41.44300 1.000 49.64046  ? 393 LEU A CD2  1 
ATOM   5480 H  H    . LEU A 1 393 ? 13.07200 30.66700  43.53400 1.000 45.02737  ? 393 LEU A H    1 
ATOM   5481 H  HA   . LEU A 1 393 ? 10.80900 29.41800  43.33400 1.000 42.40741  ? 393 LEU A HA   1 
ATOM   5482 H  HB2  . LEU A 1 393 ? 12.68500 30.20800  41.41800 1.000 49.23681  ? 393 LEU A HB2  1 
ATOM   5483 H  HB3  . LEU A 1 393 ? 11.43500 29.33700  40.96600 1.000 49.23681  ? 393 LEU A HB3  1 
ATOM   5484 H  HG   . LEU A 1 393 ? 11.14500 31.89800  42.09300 1.000 57.74126  ? 393 LEU A HG   1 
ATOM   5485 H  HD11 . LEU A 1 393 ? 10.77100 32.62600  39.86200 1.000 61.80150  ? 393 LEU A HD11 1 
ATOM   5486 H  HD12 . LEU A 1 393 ? 12.27000 32.15000  40.08800 1.000 61.80150  ? 393 LEU A HD12 1 
ATOM   5487 H  HD13 . LEU A 1 393 ? 11.23500 31.19300  39.35500 1.000 61.80150  ? 393 LEU A HD13 1 
ATOM   5488 H  HD21 . LEU A 1 393 ? 8.98100  31.79700  41.17000 1.000 59.50831  ? 393 LEU A HD21 1 
ATOM   5489 H  HD22 . LEU A 1 393 ? 9.24200  30.26400  40.84300 1.000 59.50831  ? 393 LEU A HD22 1 
ATOM   5490 H  HD23 . LEU A 1 393 ? 9.21100  30.76100  42.35200 1.000 59.50831  ? 393 LEU A HD23 1 
ATOM   5491 N  N    . ILE A 1 394 ? 13.35300 27.56400  42.71000 1.000 33.58863  ? 394 ILE A N    1 
ATOM   5492 C  CA   . ILE A 1 394 ? 13.79300 26.18100  42.57700 1.000 34.60855  ? 394 ILE A CA   1 
ATOM   5493 C  C    . ILE A 1 394 ? 13.63900 25.44200  43.90100 1.000 32.74133  ? 394 ILE A C    1 
ATOM   5494 O  O    . ILE A 1 394 ? 13.11700 24.32300  43.95000 1.000 38.61480  ? 394 ILE A O    1 
ATOM   5495 C  CB   . ILE A 1 394 ? 15.24500 26.13700  42.06600 1.000 30.98035  ? 394 ILE A CB   1 
ATOM   5496 C  CG1  . ILE A 1 394 ? 15.31100 26.69500  40.63800 1.000 23.58021  ? 394 ILE A CG1  1 
ATOM   5497 C  CG2  . ILE A 1 394 ? 15.78900 24.71200  42.12900 1.000 25.39449  ? 394 ILE A CG2  1 
ATOM   5498 C  CD1  . ILE A 1 394 ? 16.71300 27.00300  40.15400 1.000 24.79038  ? 394 ILE A CD1  1 
ATOM   5499 H  H    . ILE A 1 394 ? 13.98700 28.14400  42.66400 1.000 40.24612  ? 394 ILE A H    1 
ATOM   5500 H  HA   . ILE A 1 394 ? 13.22900 25.73500  41.92500 1.000 41.47002  ? 394 ILE A HA   1 
ATOM   5501 H  HB   . ILE A 1 394 ? 15.79800 26.69200  42.63700 1.000 37.11618  ? 394 ILE A HB   1 
ATOM   5502 H  HG12 . ILE A 1 394 ? 14.92800 26.04300  40.03200 1.000 28.23602  ? 394 ILE A HG12 1 
ATOM   5503 H  HG13 . ILE A 1 394 ? 14.80100 27.52000  40.60400 1.000 28.23602  ? 394 ILE A HG13 1 
ATOM   5504 H  HG21 . ILE A 1 394 ? 16.59000 24.65600  41.58500 1.000 30.41315  ? 394 ILE A HG21 1 
ATOM   5505 H  HG22 . ILE A 1 394 ? 16.00000 24.49600  43.05100 1.000 30.41315  ? 394 ILE A HG22 1 
ATOM   5506 H  HG23 . ILE A 1 394 ? 15.11500 24.10200  41.79200 1.000 30.41315  ? 394 ILE A HG23 1 
ATOM   5507 H  HD11 . ILE A 1 394 ? 16.65800 27.49200  39.31800 1.000 29.68821  ? 394 ILE A HD11 1 
ATOM   5508 H  HD12 . ILE A 1 394 ? 17.16700 27.54000  40.82300 1.000 29.68821  ? 394 ILE A HD12 1 
ATOM   5509 H  HD13 . ILE A 1 394 ? 17.19000 26.16900  40.02000 1.000 29.68821  ? 394 ILE A HD13 1 
ATOM   5510 N  N    . TYR A 1 395 ? 14.09500 26.05600  44.99500 1.000 37.58507  ? 395 TYR A N    1 
ATOM   5511 C  CA   . TYR A 1 395 ? 13.95500 25.43300  46.30600 1.000 34.54416  ? 395 TYR A CA   1 
ATOM   5512 C  C    . TYR A 1 395 ? 12.50800 25.05100  46.58100 1.000 42.04489  ? 395 TYR A C    1 
ATOM   5513 O  O    . TYR A 1 395 ? 12.22400 23.94700  47.06200 1.000 37.33273  ? 395 TYR A O    1 
ATOM   5514 C  CB   . TYR A 1 395 ? 14.46700 26.38200  47.39100 1.000 37.77360  ? 395 TYR A CB   1 
ATOM   5515 C  CG   . TYR A 1 395 ? 14.49500 25.77600  48.77600 1.000 38.90075  ? 395 TYR A CG   1 
ATOM   5516 C  CD1  . TYR A 1 395 ? 15.33200 24.70800  49.07100 1.000 34.03037  ? 395 TYR A CD1  1 
ATOM   5517 C  CD2  . TYR A 1 395 ? 13.68700 26.27500  49.79100 1.000 42.45824  ? 395 TYR A CD2  1 
ATOM   5518 C  CE1  . TYR A 1 395 ? 15.36300 24.15400  50.33700 1.000 37.28180  ? 395 TYR A CE1  1 
ATOM   5519 C  CE2  . TYR A 1 395 ? 13.71100 25.72700  51.05900 1.000 46.52465  ? 395 TYR A CE2  1 
ATOM   5520 C  CZ   . TYR A 1 395 ? 14.55300 24.66800  51.32600 1.000 48.00697  ? 395 TYR A CZ   1 
ATOM   5521 O  OH   . TYR A 1 395 ? 14.57900 24.11700  52.58600 1.000 39.88857  ? 395 TYR A OH   1 
ATOM   5522 H  H    . TYR A 1 395 ? 14.48500 26.82300  45.00300 1.000 45.04184  ? 395 TYR A H    1 
ATOM   5523 H  HA   . TYR A 1 395 ? 14.49300 24.62600  46.33000 1.000 41.39275  ? 395 TYR A HA   1 
ATOM   5524 H  HB2  . TYR A 1 395 ? 15.37200 26.64900  47.16800 1.000 45.26808  ? 395 TYR A HB2  1 
ATOM   5525 H  HB3  . TYR A 1 395 ? 13.88900 27.16000  47.42100 1.000 45.26808  ? 395 TYR A HB3  1 
ATOM   5526 H  HD1  . TYR A 1 395 ? 15.88000 24.35900  48.40600 1.000 40.77620  ? 395 TYR A HD1  1 
ATOM   5527 H  HD2  . TYR A 1 395 ? 13.12000 26.99100  49.61300 1.000 50.88965  ? 395 TYR A HD2  1 
ATOM   5528 H  HE1  . TYR A 1 395 ? 15.92700 23.43800  50.52000 1.000 44.67792  ? 395 TYR A HE1  1 
ATOM   5529 H  HE2  . TYR A 1 395 ? 13.16400 26.07000  51.72800 1.000 55.76934  ? 395 TYR A HE2  1 
ATOM   5530 H  HH   . TYR A 1 395 ? 15.17100 23.52200  52.62800 1.000 47.80604  ? 395 TYR A HH   1 
ATOM   5531 N  N    . LYS A 1 396 ? 11.57500 25.95200  46.27000 1.000 39.92534  ? 396 LYS A N    1 
ATOM   5532 C  CA   . LYS A 1 396 ? 10.17000 25.69400  46.56400 1.000 47.48394  ? 396 LYS A CA   1 
ATOM   5533 C  C    . LYS A 1 396 ? 9.61900  24.57100  45.69400 1.000 51.58254  ? 396 LYS A C    1 
ATOM   5534 O  O    . LYS A 1 396 ? 8.79900  23.76800  46.15600 1.000 54.32729  ? 396 LYS A O    1 
ATOM   5535 C  CB   . LYS A 1 396 ? 9.37100  26.98400  46.39000 1.000 50.99905  ? 396 LYS A CB   1 
ATOM   5536 C  CG   . LYS A 1 396 ? 9.65800  27.98500  47.50000 1.000 63.71779  ? 396 LYS A CG   1 
ATOM   5537 C  CD   . LYS A 1 396 ? 9.51100  29.43300  47.06200 1.000 73.46526  ? 396 LYS A CD   1 
ATOM   5538 C  CE   . LYS A 1 396 ? 8.06000  29.83300  46.88300 1.000 72.08869  ? 396 LYS A CE   1 
ATOM   5539 N  NZ   . LYS A 1 396 ? 7.18400  29.11200  47.84700 1.000 82.44237  ? 396 LYS A NZ   1 
ATOM   5540 H  H    . LYS A 1 396 ? 11.72800 26.71000  45.89300 1.000 47.85017  ? 396 LYS A H    1 
ATOM   5541 H  HA   . LYS A 1 396 ? 10.07900 25.40900  47.48700 1.000 56.92049  ? 396 LYS A HA   1 
ATOM   5542 H  HB2  . LYS A 1 396 ? 9.60700  27.39400  45.54300 1.000 61.13862  ? 396 LYS A HB2  1 
ATOM   5543 H  HB3  . LYS A 1 396 ? 8.42300  26.77700  46.40500 1.000 61.13862  ? 396 LYS A HB3  1 
ATOM   5544 H  HG2  . LYS A 1 396 ? 9.03700  27.83200  48.22900 1.000 76.40111  ? 396 LYS A HG2  1 
ATOM   5545 H  HG3  . LYS A 1 396 ? 10.56900 27.85900  47.80800 1.000 76.40111  ? 396 LYS A HG3  1 
ATOM   5546 H  HD2  . LYS A 1 396 ? 9.90300  30.01100  47.73600 1.000 88.09807  ? 396 LYS A HD2  1 
ATOM   5547 H  HD3  . LYS A 1 396 ? 9.96600  29.55700  46.21400 1.000 88.09807  ? 396 LYS A HD3  1 
ATOM   5548 H  HE2  . LYS A 1 396 ? 7.96600  30.78600  47.03600 1.000 86.44619  ? 396 LYS A HE2  1 
ATOM   5549 H  HE3  . LYS A 1 396 ? 7.77300  29.61200  45.98300 1.000 86.44619  ? 396 LYS A HE3  1 
ATOM   5550 H  HZ1  . LYS A 1 396 ? 6.33700  29.35800  47.73200 1.000 98.87060  ? 396 LYS A HZ1  1 
ATOM   5551 H  HZ2  . LYS A 1 396 ? 7.24900  28.23300  47.71900 1.000 98.87060  ? 396 LYS A HZ2  1 
ATOM   5552 H  HZ3  . LYS A 1 396 ? 7.43000  29.30100  48.68100 1.000 98.87060  ? 396 LYS A HZ3  1 
ATOM   5553 N  N    . GLU A 1 397 ? 10.06200 24.48700  44.43900 1.000 45.24390  ? 397 GLU A N    1 
ATOM   5554 C  CA   . GLU A 1 397 ? 9.64100  23.37400  43.59600 1.000 47.82602  ? 397 GLU A CA   1 
ATOM   5555 C  C    . GLU A 1 397 ? 10.27100 22.06500  44.05600 1.000 48.50296  ? 397 GLU A C    1 
ATOM   5556 O  O    . GLU A 1 397 ? 9.64500  21.00500  43.94800 1.000 51.65066  ? 397 GLU A O    1 
ATOM   5557 C  CB   . GLU A 1 397 ? 9.99900  23.65300  42.13600 1.000 53.05781  ? 397 GLU A CB   1 
ATOM   5558 C  CG   . GLU A 1 397 ? 9.63400  22.52600  41.18300 1.000 70.14302  ? 397 GLU A CG   1 
ATOM   5559 C  CD   . GLU A 1 397 ? 8.13700  22.29500  41.10700 1.000 76.17708  ? 397 GLU A CD   1 
ATOM   5560 O  OE1  . GLU A 1 397 ? 7.39300  23.28200  40.92300 1.000 76.50531  ? 397 GLU A OE1  1 
ATOM   5561 O  OE2  . GLU A 1 397 ? 7.70400  21.13000  41.23700 1.000 80.86753  ? 397 GLU A OE2  1 
ATOM   5562 H  H    . GLU A 1 397 ? 10.59300 25.04800  44.06100 1.000 54.23244  ? 397 GLU A H    1 
ATOM   5563 H  HA   . GLU A 1 397 ? 8.67700  23.28300  43.65200 1.000 57.33098  ? 397 GLU A HA   1 
ATOM   5564 H  HB2  . GLU A 1 397 ? 9.52500  24.44900  41.84700 1.000 63.60914  ? 397 GLU A HB2  1 
ATOM   5565 H  HB3  . GLU A 1 397 ? 10.95600 23.79500  42.07200 1.000 63.60914  ? 397 GLU A HB3  1 
ATOM   5566 H  HG2  . GLU A 1 397 ? 9.94900  22.74800  40.29300 1.000 84.11139  ? 397 GLU A HG2  1 
ATOM   5567 H  HG3  . GLU A 1 397 ? 10.05000 21.70500  41.48800 1.000 84.11139  ? 397 GLU A HG3  1 
ATOM   5568 N  N    . VAL A 1 398 ? 11.49900 22.12000  44.57700 1.000 39.30303  ? 398 VAL A N    1 
ATOM   5569 C  CA   . VAL A 1 398 ? 12.17300 20.91000  45.04100 1.000 34.33960  ? 398 VAL A CA   1 
ATOM   5570 C  C    . VAL A 1 398 ? 11.35500 20.22900  46.13200 1.000 50.65016  ? 398 VAL A C    1 
ATOM   5571 O  O    . VAL A 1 398 ? 11.10400 19.02000  46.07900 1.000 58.07032  ? 398 VAL A O    1 
ATOM   5572 C  CB   . VAL A 1 398 ? 13.59700 21.24300  45.52300 1.000 35.30437  ? 398 VAL A CB   1 
ATOM   5573 C  CG1  . VAL A 1 398 ? 14.15600 20.11400  46.37600 1.000 40.32030  ? 398 VAL A CG1  1 
ATOM   5574 C  CG2  . VAL A 1 398 ? 14.50300 21.49300  44.32700 1.000 37.94206  ? 398 VAL A CG2  1 
ATOM   5575 H  H    . VAL A 1 398 ? 11.95900 22.84100  44.67200 1.000 47.10340  ? 398 VAL A H    1 
ATOM   5576 H  HA   . VAL A 1 398 ? 12.24500 20.29200  44.29600 1.000 41.14728  ? 398 VAL A HA   1 
ATOM   5577 H  HB   . VAL A 1 398 ? 13.56500 22.04500  46.06700 1.000 42.30501  ? 398 VAL A HB   1 
ATOM   5578 H  HG11 . VAL A 1 398 ? 15.11700 20.21800  46.44800 1.000 48.32412  ? 398 VAL A HG11 1 
ATOM   5579 H  HG12 . VAL A 1 398 ? 13.75300 20.15500  47.25800 1.000 48.32412  ? 398 VAL A HG12 1 
ATOM   5580 H  HG13 . VAL A 1 398 ? 13.94500 19.26600  45.95600 1.000 48.32412  ? 398 VAL A HG13 1 
ATOM   5581 H  HG21 . VAL A 1 398 ? 15.31700 21.92500  44.63200 1.000 45.47024  ? 398 VAL A HG21 1 
ATOM   5582 H  HG22 . VAL A 1 398 ? 14.71600 20.64400  43.90900 1.000 45.47024  ? 398 VAL A HG22 1 
ATOM   5583 H  HG23 . VAL A 1 398 ? 14.04200 22.06700  43.69600 1.000 45.47024  ? 398 VAL A HG23 1 
ATOM   5584 N  N    . MET A 1 399 ? 10.93600 20.98600  47.14200 1.000 53.12859  ? 399 MET A N    1 
ATOM   5585 C  CA   . MET A 1 399 ? 10.09500 20.45600  48.21300 1.000 62.34517  ? 399 MET A CA   1 
ATOM   5586 C  C    . MET A 1 399 ? 8.71900  21.10300  48.07200 1.000 69.05005  ? 399 MET A C    1 
ATOM   5587 O  O    . MET A 1 399 ? 8.39800  22.10200  48.71900 1.000 86.49786  ? 399 MET A O    1 
ATOM   5588 C  CB   . MET A 1 399 ? 10.71800 20.68900  49.59900 1.000 56.30270  ? 399 MET A CB   1 
ATOM   5589 C  CG   . MET A 1 399 ? 11.25300 22.09100  49.86400 1.000 44.36642  ? 399 MET A CG   1 
ATOM   5590 S  SD   . MET A 1 399 ? 12.54800 22.17500  51.13200 1.000 82.88089  ? 399 MET A SD   1 
ATOM   5591 C  CE   . MET A 1 399 ? 13.49900 20.67500  50.87600 1.000 42.51168  ? 399 MET A CE   1 
ATOM   5592 H  H    . MET A 1 399 ? 11.12800 21.82000  47.23000 1.000 63.69407  ? 399 MET A H    1 
ATOM   5593 H  HA   . MET A 1 399 ? 10.01700 19.49600  48.10300 1.000 74.75397  ? 399 MET A HA   1 
ATOM   5594 H  HB2  . MET A 1 399 ? 10.04000 20.50900  50.27000 1.000 67.50301  ? 399 MET A HB2  1 
ATOM   5595 H  HB3  . MET A 1 399 ? 11.46100 20.07400  49.70500 1.000 67.50301  ? 399 MET A HB3  1 
ATOM   5596 H  HG2  . MET A 1 399 ? 11.62700 22.44000  49.04000 1.000 53.17946  ? 399 MET A HG2  1 
ATOM   5597 H  HG3  . MET A 1 399 ? 10.51800 22.65200  50.15900 1.000 53.17946  ? 399 MET A HG3  1 
ATOM   5598 H  HE1  . MET A 1 399 ? 14.30200 20.71400  51.41900 1.000 50.95378  ? 399 MET A HE1  1 
ATOM   5599 H  HE2  . MET A 1 399 ? 12.96000 19.91100  51.13600 1.000 50.95378  ? 399 MET A HE2  1 
ATOM   5600 H  HE3  . MET A 1 399 ? 13.73800 20.60800  49.93800 1.000 50.95378  ? 399 MET A HE3  1 
ATOM   5601 N  N    . ASN A 1 400 ? 7.90900  20.50900  47.20200 1.000 67.58555  ? 400 ASN A N    1 
ATOM   5602 C  CA   . ASN A 1 400 ? 6.57100  20.98200  46.87300 1.000 69.95265  ? 400 ASN A CA   1 
ATOM   5603 C  C    . ASN A 1 400 ? 5.80100  21.46100  48.09800 1.000 78.38987  ? 400 ASN A C    1 
ATOM   5604 O  O    . ASN A 1 400 ? 5.82000  22.64700  48.43200 1.000 70.26905  ? 400 ASN A O    1 
ATOM   5605 C  CB   . ASN A 1 400 ? 5.79700  19.86000  46.17400 1.000 67.46599  ? 400 ASN A CB   1 
ATOM   5606 C  CG   . ASN A 1 400 ? 6.49100  19.36700  44.91500 1.000 73.26576  ? 400 ASN A CG   1 
ATOM   5607 O  OD1  . ASN A 1 400 ? 6.34900  19.95400  43.84200 1.000 62.61245  ? 400 ASN A OD1  1 
ATOM   5608 N  ND2  . ASN A 1 400 ? 7.26100  18.29200  45.04700 1.000 78.75984  ? 400 ASN A ND2  1 
ATOM   5609 H  H    . ASN A 1 400 ? 8.12100  19.79700  46.76900 1.000 81.04242  ? 400 ASN A H    1 
ATOM   5610 H  HA   . ASN A 1 400 ? 6.64800  21.74500  46.27900 1.000 83.88295  ? 400 ASN A HA   1 
ATOM   5611 H  HB2  . ASN A 1 400 ? 5.70900  19.10900  46.78200 1.000 80.89895  ? 400 ASN A HB2  1 
ATOM   5612 H  HB3  . ASN A 1 400 ? 4.91900  20.18900  45.92400 1.000 80.89895  ? 400 ASN A HB3  1 
ATOM   5613 H  HD21 . ASN A 1 400 ? 7.34400  17.91300  45.81500 1.000 94.45157  ? 400 ASN A HD21 1 
ATOM   5614 H  HD22 . ASN A 1 400 ? 7.67500  17.97400  44.36400 1.000 94.45157  ? 400 ASN A HD22 1 
HETATM 5615 C  C13  . WHQ B 2 .   ? 18.57500 11.69600  36.67400 1.000 26.42387  ? 501 WHQ A C13  1 
HETATM 5616 C  C15  . WHQ B 2 .   ? 22.84100 4.57500   31.99000 1.000 24.67777  ? 501 WHQ A C15  1 
HETATM 5617 C  C17  . WHQ B 2 .   ? 23.22200 6.29300   30.35600 1.000 25.16845  ? 501 WHQ A C17  1 
HETATM 5618 C  C21  . WHQ B 2 .   ? 23.84900 12.56100  30.01200 1.000 39.07539  ? 501 WHQ A C21  1 
HETATM 5619 O  O01  . WHQ B 2 .   ? 25.74200 2.48100   31.28400 1.000 38.17418  ? 501 WHQ A O01  1 
HETATM 5620 C  C11  . WHQ B 2 .   ? 17.42700 13.27900  35.19300 1.000 22.78141  ? 501 WHQ A C11  1 
HETATM 5621 C  C12  . WHQ B 2 .   ? 17.57100 12.52900  36.50500 1.000 25.00226  ? 501 WHQ A C12  1 
HETATM 5622 C  C16  . WHQ B 2 .   ? 23.97400 4.03100   31.28800 1.000 23.94660  ? 501 WHQ A C16  1 
HETATM 5623 C  C19  . WHQ B 2 .   ? 24.51500 0.45100   32.72500 1.000 45.24698  ? 501 WHQ A C19  1 
HETATM 5624 CL CL1  . WHQ B 2 .   ? 18.16200 13.96000  32.70500 1.000 34.21261  ? 501 WHQ A CL1  1 
HETATM 5625 C  C1   . WHQ B 2 .   ? 22.42400 5.86100   31.43200 1.000 24.67428  ? 501 WHQ A C1   1 
HETATM 5626 C  C10  . WHQ B 2 .   ? 18.31100 13.09000  34.23700 1.000 28.12545  ? 501 WHQ A C10  1 
HETATM 5627 C  C14  . WHQ B 2 .   ? 19.59700 11.48500  35.56500 1.000 27.37965  ? 501 WHQ A C14  1 
HETATM 5628 C  C18  . WHQ B 2 .   ? 24.63200 2.70300   31.63100 1.000 28.59274  ? 501 WHQ A C18  1 
HETATM 5629 C  C2   . WHQ B 2 .   ? 21.42200 8.01700   32.21800 1.000 28.03991  ? 501 WHQ A C2   1 
HETATM 5630 C  C20  . WHQ B 2 .   ? 23.04500 11.40200  31.92400 1.000 29.43518  ? 501 WHQ A C20  1 
HETATM 5631 C  C3   . WHQ B 2 .   ? 20.18200 8.28300   32.85300 1.000 24.14259  ? 501 WHQ A C3   1 
HETATM 5632 C  C4   . WHQ B 2 .   ? 19.54300 7.01100   32.97300 1.000 25.84669  ? 501 WHQ A C4   1 
HETATM 5633 C  C5   . WHQ B 2 .   ? 22.31300 9.01200   31.93700 1.000 25.68282  ? 501 WHQ A C5   1 
HETATM 5634 C  C6   . WHQ B 2 .   ? 22.02000 10.32600  32.27400 1.000 28.90470  ? 501 WHQ A C6   1 
HETATM 5635 C  C7   . WHQ B 2 .   ? 20.78300 10.61600  32.90400 1.000 28.42109  ? 501 WHQ A C7   1 
HETATM 5636 C  C8   . WHQ B 2 .   ? 19.87700 9.58000   33.18400 1.000 25.25824  ? 501 WHQ A C8   1 
HETATM 5637 C  C9   . WHQ B 2 .   ? 19.48300 12.13800  34.41600 1.000 24.07599  ? 501 WHQ A C9   1 
HETATM 5638 F  F1   . WHQ B 2 .   ? 20.62000 10.61800  35.79500 1.000 24.35929  ? 501 WHQ A F1   1 
HETATM 5639 N  N1   . WHQ B 2 .   ? 21.32700 6.59300   32.01700 1.000 22.56213  ? 501 WHQ A N1   1 
HETATM 5640 N  N2   . WHQ B 2 .   ? 20.22700 6.03100   32.50200 1.000 26.18065  ? 501 WHQ A N2   1 
HETATM 5641 N  N3   . WHQ B 2 .   ? 20.41900 11.96700  33.30500 1.000 24.09905  ? 501 WHQ A N3   1 
HETATM 5642 N  N4   . WHQ B 2 .   ? 23.89700 1.72200   32.39800 1.000 35.39294  ? 501 WHQ A N4   1 
HETATM 5643 O  O1   . WHQ B 2 .   ? 22.93600 11.64100  30.54500 1.000 43.12067  ? 501 WHQ A O1   1 
HETATM 5644 S  S1   . WHQ B 2 .   ? 24.46200 5.13800   30.00900 1.000 30.38675  ? 501 WHQ A S1   1 
HETATM 5645 H  H7   . WHQ B 2 .   ? 18.66000 11.23300  37.47600 1.000 31.64840  ? 501 WHQ A H7   1 
HETATM 5646 H  H8   . WHQ B 2 .   ? 22.26400 4.04300   32.48800 1.000 29.55309  ? 501 WHQ A H8   1 
HETATM 5647 H  H9   . WHQ B 2 .   ? 22.93900 6.85400   29.77400 1.000 30.14190  ? 501 WHQ A H9   1 
HETATM 5648 H  H21  . WHQ B 2 .   ? 24.70300 12.17300  29.98300 1.000 46.83023  ? 501 WHQ A H21  1 
HETATM 5649 H  H17  . WHQ B 2 .   ? 23.87100 13.32800  30.55200 1.000 46.83023  ? 501 WHQ A H17  1 
HETATM 5650 H  H16  . WHQ B 2 .   ? 23.58300 12.79700  29.14300 1.000 46.83023  ? 501 WHQ A H16  1 
HETATM 5651 H  H5   . WHQ B 2 .   ? 16.71900 13.86900  35.06600 1.000 27.27745  ? 501 WHQ A H5   1 
HETATM 5652 H  H6   . WHQ B 2 .   ? 16.95200 12.65800  37.18600 1.000 29.94248  ? 501 WHQ A H6   1 
HETATM 5653 H  H12  . WHQ B 2 .   ? 23.89400 -0.09300  33.17100 1.000 54.23614  ? 501 WHQ A H12  1 
HETATM 5654 H  H13  . WHQ B 2 .   ? 25.25800 0.59800   33.28000 1.000 54.23614  ? 501 WHQ A H13  1 
HETATM 5655 H  H11  . WHQ B 2 .   ? 24.79400 0.02600   31.93500 1.000 54.23614  ? 501 WHQ A H11  1 
HETATM 5656 H  H15  . WHQ B 2 .   ? 23.91100 11.10300  32.13200 1.000 35.26197  ? 501 WHQ A H15  1 
HETATM 5657 H  H14  . WHQ B 2 .   ? 22.86300 12.18900  32.40300 1.000 35.26197  ? 501 WHQ A H14  1 
HETATM 5658 H  H1   . WHQ B 2 .   ? 18.70500 6.90200   33.35900 1.000 30.95579  ? 501 WHQ A H1   1 
HETATM 5659 H  H2   . WHQ B 2 .   ? 23.11800 8.80900   31.51800 1.000 30.75915  ? 501 WHQ A H2   1 
HETATM 5660 H  H3   . WHQ B 2 .   ? 19.06700 9.77400   33.59500 1.000 30.24965  ? 501 WHQ A H3   1 
HETATM 5661 H  H4   . WHQ B 2 .   ? 20.75000 12.65600  32.89400 1.000 28.85863  ? 501 WHQ A H4   1 
HETATM 5662 H  H10  . WHQ B 2 .   ? 23.08800 1.89300   32.66100 1.000 42.41129  ? 501 WHQ A H10  1 
HETATM 5663 O  O    . HOH C 3 .   ? 26.65300 29.31200  5.59900  1.000 36.63421  ? 601 HOH A O    1 
HETATM 5664 O  O    . HOH C 3 .   ? 2.29300  9.63200   22.12700 1.000 50.86893  ? 602 HOH A O    1 
HETATM 5665 O  O    . HOH C 3 .   ? 22.36000 30.82900  -2.14000 1.000 36.26664  ? 603 HOH A O    1 
HETATM 5666 O  O    . HOH C 3 .   ? 2.64000  15.64300  6.82100  1.000 42.64855  ? 604 HOH A O    1 
HETATM 5667 O  O    . HOH C 3 .   ? 12.53100 33.58100  31.43400 1.000 62.43346  ? 605 HOH A O    1 
HETATM 5668 O  O    . HOH C 3 .   ? 24.96400 1.84900   7.43000  1.000 33.75150  ? 606 HOH A O    1 
HETATM 5669 O  O    . HOH C 3 .   ? 24.32200 -6.17500  11.21100 1.000 44.72145  ? 607 HOH A O    1 
HETATM 5670 O  O    . HOH C 3 .   ? 13.42700 -12.79700 -4.72200 1.000 44.31502  ? 608 HOH A O    1 
HETATM 5671 O  O    . HOH C 3 .   ? 15.61200 -10.70500 6.25200  1.000 40.27113  ? 609 HOH A O    1 
HETATM 5672 O  O    . HOH C 3 .   ? 13.59100 39.81900  44.80100 1.000 51.14604  ? 610 HOH A O    1 
HETATM 5673 O  O    . HOH C 3 .   ? 15.92700 -1.48300  -1.23300 1.000 39.69116  ? 611 HOH A O    1 
HETATM 5674 O  O    . HOH C 3 .   ? 8.60500  2.12500   24.87700 1.000 37.10345  ? 612 HOH A O    1 
HETATM 5675 O  O    . HOH C 3 .   ? 11.30500 -1.95000  29.42700 1.000 57.77349  ? 613 HOH A O    1 
HETATM 5676 O  O    . HOH C 3 .   ? 12.52600 1.84100   29.03000 1.000 51.28308  ? 614 HOH A O    1 
HETATM 5677 O  O    . HOH C 3 .   ? 14.27300 6.50700   44.32500 1.000 26.85649  ? 615 HOH A O    1 
HETATM 5678 O  O    . HOH C 3 .   ? 25.07600 18.12800  47.83900 1.000 29.43339  ? 616 HOH A O    1 
HETATM 5679 O  O    . HOH C 3 .   ? 10.58400 4.65900   34.34300 1.000 56.49691  ? 617 HOH A O    1 
HETATM 5680 O  O    . HOH C 3 .   ? 17.87700 17.21700  34.14600 1.000 31.10012  ? 618 HOH A O    1 
HETATM 5681 O  O    . HOH C 3 .   ? 8.84600  30.27300  21.64700 1.000 46.16859  ? 619 HOH A O    1 
HETATM 5682 O  O    . HOH C 3 .   ? 11.52100 -6.51600  -1.61100 1.000 29.31379  ? 620 HOH A O    1 
HETATM 5683 O  O    . HOH C 3 .   ? 20.86300 20.41700  11.63300 1.000 24.40718  ? 621 HOH A O    1 
HETATM 5684 O  O    . HOH C 3 .   ? 28.36900 24.45000  47.03100 1.000 55.00819  ? 622 HOH A O    1 
HETATM 5685 O  O    . HOH C 3 .   ? 14.48400 14.39000  53.56100 1.000 55.37614  ? 623 HOH A O    1 
HETATM 5686 O  O    . HOH C 3 .   ? 2.39800  22.01000  20.44400 1.000 38.49061  ? 624 HOH A O    1 
HETATM 5687 O  O    . HOH C 3 .   ? 27.15800 2.99600   49.24700 1.000 37.44972  ? 625 HOH A O    1 
HETATM 5688 O  O    . HOH C 3 .   ? 17.72600 -3.46600  31.11100 1.000 47.16232  ? 626 HOH A O    1 
HETATM 5689 O  O    . HOH C 3 .   ? 16.64700 17.89900  -1.04400 1.000 38.03439  ? 627 HOH A O    1 
HETATM 5690 O  O    . HOH C 3 .   ? 7.90800  15.69100  3.13700  1.000 37.55503  ? 628 HOH A O    1 
HETATM 5691 O  O    . HOH C 3 .   ? 8.46300  24.14500  11.88100 1.000 26.60441  ? 629 HOH A O    1 
HETATM 5692 O  O    . HOH C 3 .   ? 14.40900 19.28700  17.96500 1.000 24.92325  ? 630 HOH A O    1 
HETATM 5693 O  O    . HOH C 3 .   ? 5.50300  -2.69000  3.99700  1.000 48.69482  ? 631 HOH A O    1 
HETATM 5694 O  O    . HOH C 3 .   ? 17.26000 19.91800  34.28500 1.000 33.82322  ? 632 HOH A O    1 
HETATM 5695 O  O    . HOH C 3 .   ? 9.90900  3.44400   27.40100 1.000 41.71379  ? 633 HOH A O    1 
HETATM 5696 O  O    . HOH C 3 .   ? 9.72200  -1.46600  9.89500  1.000 35.08344  ? 634 HOH A O    1 
HETATM 5697 O  O    . HOH C 3 .   ? 15.93400 0.03400   34.96600 1.000 44.75447  ? 635 HOH A O    1 
HETATM 5698 O  O    . HOH C 3 .   ? 17.86800 16.95300  23.57800 1.000 30.61155  ? 636 HOH A O    1 
HETATM 5699 O  O    . HOH C 3 .   ? 31.22400 19.78500  14.05500 1.000 34.43217  ? 637 HOH A O    1 
HETATM 5700 O  O    . HOH C 3 .   ? 12.38000 6.80400   36.06900 1.000 29.52515  ? 638 HOH A O    1 
HETATM 5701 O  O    . HOH C 3 .   ? 14.93200 20.52500  1.46400  1.000 26.30017  ? 639 HOH A O    1 
HETATM 5702 O  O    . HOH C 3 .   ? 15.21500 17.65500  1.09700  1.000 29.76962  ? 640 HOH A O    1 
HETATM 5703 O  O    . HOH C 3 .   ? 7.41100  12.73000  33.93800 1.000 45.14451  ? 641 HOH A O    1 
HETATM 5704 O  O    . HOH C 3 .   ? 19.66200 29.20800  17.99000 1.000 47.70282  ? 642 HOH A O    1 
HETATM 5705 O  O    . HOH C 3 .   ? 17.92000 8.27000   54.90400 1.000 28.78169  ? 643 HOH A O    1 
HETATM 5706 O  O    . HOH C 3 .   ? 27.75700 22.69600  44.96100 1.000 39.29828  ? 644 HOH A O    1 
HETATM 5707 O  O    . HOH C 3 .   ? 24.46700 24.32500  37.69900 1.000 51.21522  ? 645 HOH A O    1 
HETATM 5708 O  O    . HOH C 3 .   ? 22.26200 28.36700  -1.39000 1.000 32.69256  ? 646 HOH A O    1 
HETATM 5709 O  O    . HOH C 3 .   ? 17.39000 7.19000   52.42400 1.000 32.43870  ? 647 HOH A O    1 
HETATM 5710 O  O    . HOH C 3 .   ? 1.32300  15.99600  13.66400 1.000 48.82165  ? 648 HOH A O    1 
HETATM 5711 O  O    . HOH C 3 .   ? 6.78100  10.52500  31.64900 1.000 32.48420  ? 649 HOH A O    1 
HETATM 5712 O  O    . HOH C 3 .   ? 19.21600 19.64400  18.18400 1.000 32.04906  ? 650 HOH A O    1 
HETATM 5713 O  O    . HOH C 3 .   ? 14.98100 0.45900   37.74000 1.000 48.10054  ? 651 HOH A O    1 
HETATM 5714 O  O    . HOH C 3 .   ? 26.29400 1.40300   27.94500 1.000 42.06854  ? 652 HOH A O    1 
HETATM 5715 O  O    . HOH C 3 .   ? 9.28400  7.29500   31.94200 1.000 33.35654  ? 653 HOH A O    1 
HETATM 5716 O  O    . HOH C 3 .   ? 14.98600 -8.86700  -5.89800 1.000 42.01425  ? 654 HOH A O    1 
HETATM 5717 O  O    . HOH C 3 .   ? 5.80400  4.16100   22.09600 1.000 43.40787  ? 655 HOH A O    1 
HETATM 5718 O  O    . HOH C 3 .   ? 21.77000 29.25500  1.22200  1.000 31.96975  ? 656 HOH A O    1 
HETATM 5719 O  O    . HOH C 3 .   ? 15.90900 11.99700  -3.87900 1.000 39.06934  ? 657 HOH A O    1 
HETATM 5720 O  O    . HOH C 3 .   ? 16.63400 -5.84700  9.37600  1.000 36.29154  ? 658 HOH A O    1 
HETATM 5721 O  O    . HOH C 3 .   ? 17.02500 -2.48800  38.67000 1.000 32.77941  ? 659 HOH A O    1 
HETATM 5722 O  O    . HOH C 3 .   ? 28.18100 30.70200  37.04400 1.000 45.80126  ? 660 HOH A O    1 
HETATM 5723 O  O    . HOH C 3 .   ? 23.52300 16.49000  11.65500 1.000 24.91554  ? 661 HOH A O    1 
HETATM 5724 O  O    . HOH C 3 .   ? 2.48700  8.32900   6.18800  1.000 41.76650  ? 662 HOH A O    1 
HETATM 5725 O  O    . HOH C 3 .   ? 28.47700 1.42700   20.29900 1.000 43.91357  ? 663 HOH A O    1 
HETATM 5726 O  O    . HOH C 3 .   ? 8.17900  12.65200  37.07400 1.000 44.98886  ? 664 HOH A O    1 
HETATM 5727 O  O    . HOH C 3 .   ? 30.16500 3.00100   13.91400 1.000 48.74383  ? 665 HOH A O    1 
HETATM 5728 O  O    . HOH C 3 .   ? 15.23200 21.76200  15.87900 1.000 25.35620  ? 666 HOH A O    1 
HETATM 5729 O  O    . HOH C 3 .   ? 21.11500 1.61100   52.49100 1.000 36.07936  ? 667 HOH A O    1 
HETATM 5730 O  O    . HOH C 3 .   ? 18.84100 -0.99400  33.28500 1.000 45.74849  ? 668 HOH A O    1 
HETATM 5731 O  O    . HOH C 3 .   ? 21.63400 19.70600  18.08500 1.000 25.81189  ? 669 HOH A O    1 
HETATM 5732 O  O    . HOH C 3 .   ? 32.80100 29.05600  7.29100  1.000 48.52478  ? 670 HOH A O    1 
HETATM 5733 O  O    . HOH C 3 .   ? 18.54000 27.84400  29.79900 1.000 37.70821  ? 671 HOH A O    1 
HETATM 5734 O  O    . HOH C 3 .   ? 13.04400 23.98700  -0.79100 1.000 49.20437  ? 672 HOH A O    1 
HETATM 5735 O  O    . HOH C 3 .   ? 20.11200 14.78000  29.70900 1.000 42.69864  ? 673 HOH A O    1 
HETATM 5736 O  O    . HOH C 3 .   ? 28.04600 4.95300   47.15700 1.000 40.97519  ? 674 HOH A O    1 
HETATM 5737 O  O    . HOH C 3 .   ? 10.64100 -3.13100  10.87100 1.000 39.35017  ? 675 HOH A O    1 
HETATM 5738 O  O    . HOH C 3 .   ? 21.37400 14.59800  32.01400 1.000 29.07702  ? 676 HOH A O    1 
HETATM 5739 O  O    . HOH C 3 .   ? 28.19400 13.25500  6.95000  1.000 42.69287  ? 677 HOH A O    1 
HETATM 5740 O  O    . HOH C 3 .   ? 15.89500 17.54400  52.79100 1.000 50.06140  ? 678 HOH A O    1 
HETATM 5741 O  O    . HOH C 3 .   ? 12.77400 16.87900  48.47900 1.000 45.56087  ? 679 HOH A O    1 
HETATM 5742 O  O    . HOH C 3 .   ? 9.11600  28.41400  9.67700  1.000 50.16785  ? 680 HOH A O    1 
HETATM 5743 O  O    . HOH C 3 .   ? 27.48800 8.33100   18.06400 1.000 42.20453  ? 681 HOH A O    1 
HETATM 5744 O  O    . HOH C 3 .   ? 17.88000 16.43000  31.07400 1.000 42.44070  ? 682 HOH A O    1 
HETATM 5745 O  O    . HOH C 3 .   ? 1.44000  21.53400  13.80200 1.000 54.65153  ? 683 HOH A O    1 
HETATM 5746 O  O    . HOH C 3 .   ? 14.09100 -12.93700 0.54200  1.000 33.68203  ? 684 HOH A O    1 
HETATM 5747 O  O    . HOH C 3 .   ? 25.51700 20.89600  37.92500 1.000 42.37248  ? 685 HOH A O    1 
HETATM 5748 O  O    . HOH C 3 .   ? 25.68200 13.12900  19.04600 1.000 43.06940  ? 686 HOH A O    1 
HETATM 5749 O  O    . HOH C 3 .   ? 14.28800 -8.79700  12.85600 1.000 49.45849  ? 687 HOH A O    1 
HETATM 5750 O  O    . HOH C 3 .   ? 22.59200 31.28200  11.14400 1.000 35.77055  ? 688 HOH A O    1 
HETATM 5751 O  O    . HOH C 3 .   ? 9.63700  11.94400  -0.91600 1.000 44.59498  ? 689 HOH A O    1 
HETATM 5752 O  O    . HOH C 3 .   ? 3.04800  5.58900   28.49900 1.000 45.20831  ? 690 HOH A O    1 
HETATM 5753 O  O    . HOH C 3 .   ? 13.04900 15.86200  -0.11800 1.000 45.81252  ? 691 HOH A O    1 
HETATM 5754 O  O    . HOH C 3 .   ? 11.50000 7.57700   33.45200 1.000 37.68693  ? 692 HOH A O    1 
HETATM 5755 O  O    . HOH C 3 .   ? 30.43400 14.26000  9.83300  1.000 41.65389  ? 693 HOH A O    1 
HETATM 5756 O  O    . HOH C 3 .   ? 12.68400 22.15900  1.23500  1.000 35.05808  ? 694 HOH A O    1 
HETATM 5757 O  O    . HOH C 3 .   ? 8.33400  27.59400  42.46600 1.000 45.78629  ? 695 HOH A O    1 
HETATM 5758 O  O    . HOH C 3 .   ? 2.77800  16.99500  16.35300 1.000 36.18194  ? 696 HOH A O    1 
HETATM 5759 O  O    . HOH C 3 .   ? 23.23300 13.78200  12.33700 1.000 24.79013  ? 697 HOH A O    1 
HETATM 5760 O  O    . HOH C 3 .   ? 3.93700  17.74800  13.45900 1.000 35.97040  ? 698 HOH A O    1 
HETATM 5761 O  O    . HOH C 3 .   ? 8.82500  1.97300   -0.60300 1.000 39.69280  ? 699 HOH A O    1 
HETATM 5762 O  O    . HOH C 3 .   ? 6.26700  1.10900   22.38100 1.000 42.22769  ? 700 HOH A O    1 
HETATM 5763 O  O    . HOH C 3 .   ? 24.52000 9.20500   29.04800 1.000 26.60676  ? 701 HOH A O    1 
HETATM 5764 O  O    . HOH C 3 .   ? 20.61000 33.29200  38.17600 1.000 43.15190  ? 702 HOH A O    1 
HETATM 5765 O  O    . HOH C 3 .   ? 32.10500 6.29500   11.34700 1.000 54.04843  ? 703 HOH A O    1 
HETATM 5766 O  O    . HOH C 3 .   ? 19.43100 21.14500  34.17700 1.000 38.82138  ? 704 HOH A O    1 
HETATM 5767 O  O    . HOH C 3 .   ? 31.02100 21.64900  8.42400  1.000 35.50871  ? 705 HOH A O    1 
HETATM 5768 O  O    . HOH C 3 .   ? 6.30800  30.17900  16.24800 1.000 43.27481  ? 706 HOH A O    1 
HETATM 5769 O  O    . HOH C 3 .   ? 27.67300 22.05100  17.76300 1.000 37.65421  ? 707 HOH A O    1 
HETATM 5770 O  O    . HOH C 3 .   ? 6.79800  -0.47800  25.49000 1.000 47.15724  ? 708 HOH A O    1 
HETATM 5771 O  O    . HOH C 3 .   ? 15.71100 20.10000  36.51600 1.000 40.89169  ? 709 HOH A O    1 
HETATM 5772 O  O    . HOH C 3 .   ? 23.96300 14.54400  20.79600 1.000 29.35376  ? 710 HOH A O    1 
HETATM 5773 O  O    . HOH C 3 .   ? 25.57600 -0.90000  52.08000 1.000 42.96034  ? 711 HOH A O    1 
HETATM 5774 O  O    . HOH C 3 .   ? 31.65700 29.59900  5.12700  1.000 39.79830  ? 712 HOH A O    1 
HETATM 5775 O  O    . HOH C 3 .   ? 23.66400 30.27800  8.91100  1.000 44.11036  ? 713 HOH A O    1 
HETATM 5776 O  O    . HOH C 3 .   ? 28.62200 -2.63700  40.88800 1.000 43.39700  ? 714 HOH A O    1 
HETATM 5777 O  O    . HOH C 3 .   ? 24.55500 19.66200  24.01700 1.000 39.45797  ? 715 HOH A O    1 
HETATM 5778 O  O    . HOH C 3 .   ? 15.88200 -4.26300  29.11100 1.000 38.89320  ? 716 HOH A O    1 
HETATM 5779 O  O    . HOH C 3 .   ? 13.045   4.969     -1.808   1.000 36.67253  ? 717 HOH A O    1 
HETATM 5780 O  O    . HOH C 3 .   ? 25.83700 10.67000  18.15500 1.000 41.37400  ? 718 HOH A O    1 
HETATM 5781 O  O    . HOH C 3 .   ? 3.65200  20.48600  12.23000 1.000 46.62209  ? 719 HOH A O    1 
HETATM 5782 O  O    . HOH C 3 .   ? 19.46900 -1.92500  35.91200 1.000 41.98615  ? 720 HOH A O    1 
HETATM 5783 O  O    . HOH C 3 .   ? 0.58600  15.98600  19.21500 1.000 49.88658  ? 721 HOH A O    1 
HETATM 5784 O  O    . HOH C 3 .   ? 14.57300 17.13600  49.91500 1.000 28.61614  ? 722 HOH A O    1 
HETATM 5785 O  O    . HOH C 3 .   ? 8.12100  24.76400  24.52800 1.000 45.46431  ? 723 HOH A O    1 
HETATM 5786 O  O    . HOH C 3 .   ? 13.37600 -3.51700  49.47300 1.000 47.73486  ? 724 HOH A O    1 
HETATM 5787 O  O    . HOH C 3 .   ? 0.98000  19.16100  16.11000 1.000 56.78034  ? 725 HOH A O    1 
HETATM 5788 O  O    . HOH C 3 .   ? 32.72700 29.59400  10.06800 1.000 43.35029  ? 726 HOH A O    1 
HETATM 5789 O  O    . HOH C 3 .   ? 0.02700  19.08600  19.25600 1.000 49.23614  ? 727 HOH A O    1 
HETATM 5790 O  O    . HOH C 3 .   ? 7.63200  4.00300   1.49600  1.000 42.28638  ? 728 HOH A O    1 
HETATM 5791 O  O    . HOH C 3 .   ? 7.12700  26.33700  10.58000 1.000 36.74489  ? 729 HOH A O    1 
HETATM 5792 O  O    . HOH C 3 .   ? 9.07500  15.29600  0.46500  1.000 45.72569  ? 730 HOH A O    1 
HETATM 5793 O  O    . HOH C 3 .   ? 17.92000 7.40100   57.76100 1.000 47.02915  ? 731 HOH A O    1 
HETATM 5794 O  O    . HOH C 3 .   ? 12.14200 -14.25800 -3.32500 1.000 38.86403  ? 732 HOH A O    1 
HETATM 5795 O  O    . HOH C 3 .   ? 10.88700 17.80400  -0.74300 1.000 40.13253  ? 733 HOH A O    1 
# 
