data_8VJD
# 
_entry.id   8VJD 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8VJD         pdb_00008vjd 10.2210/pdb8vjd/pdb 
WWPDB D_1000280209 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2024-11-06 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8VJD 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gregorb@ucr.edu 
_pdbx_contact_author.name_first         Gregor 
_pdbx_contact_author.name_last          Blaha 
_pdbx_contact_author.name_mi            M. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7228-0185 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Rodriguez, I.' 1 ? 
'Blaha, G.'     2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Proc.Natl.Acad.Sci.USA 
_citation.journal_id_ASTM           PNASA6 
_citation.journal_id_CSD            0040 
_citation.journal_id_ISSN           1091-6490 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            121 
_citation.language                  ? 
_citation.page_first                e2403330121 
_citation.page_last                 e2403330121 
_citation.title                     'Targeted degradation of Pin1 by protein-destabilizing compounds.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1073/pnas.2403330121 
_citation.pdbx_database_id_PubMed   39531501 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Alboreggia, G.'  1 ?                   
primary 'Udompholkul, P.' 2 ?                   
primary 'Rodriguez, I.'   3 0009-0004-7522-8947 
primary 'Blaha, G.'       4 0000-0001-7228-0185 
primary 'Pellecchia, M.'  5 0000-0001-5179-470X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1' 18467.473 2   5.2.1.8 R14A ? ? 
2 polymer     syn 'Inhibitor 158F10'                                       516.612   2   ?       ?    ? ? 
3 non-polymer syn 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL                  326.383   2   ?       ?    ? ? 
4 non-polymer syn 'SULFATE ION'                                            96.063    9   ?       ?    ? ? 
5 water       nat water                                                    18.015    265 ?       ?    ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Peptidyl-prolyl cis-trans isomerase Pin1,PPIase Pin1,Rotamase Pin1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no  
;GSHMADEEKLPPGWEKAMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEK
ITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIH
IILRTE
;
;GSHMADEEKLPPGWEKAMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEK
ITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIH
IILRTE
;
A,B ? 
2 'polypeptide(L)' no yes '(ACE)F(YCP)(A1A2Y)(NH2)' XFXXX C,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL P33 
4 'SULFATE ION'                           SO4 
5 water                                   HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY   n 
1 2   SER   n 
1 3   HIS   n 
1 4   MET   n 
1 5   ALA   n 
1 6   ASP   n 
1 7   GLU   n 
1 8   GLU   n 
1 9   LYS   n 
1 10  LEU   n 
1 11  PRO   n 
1 12  PRO   n 
1 13  GLY   n 
1 14  TRP   n 
1 15  GLU   n 
1 16  LYS   n 
1 17  ALA   n 
1 18  MET   n 
1 19  SER   n 
1 20  ARG   n 
1 21  SER   n 
1 22  SER   n 
1 23  GLY   n 
1 24  ARG   n 
1 25  VAL   n 
1 26  TYR   n 
1 27  TYR   n 
1 28  PHE   n 
1 29  ASN   n 
1 30  HIS   n 
1 31  ILE   n 
1 32  THR   n 
1 33  ASN   n 
1 34  ALA   n 
1 35  SER   n 
1 36  GLN   n 
1 37  TRP   n 
1 38  GLU   n 
1 39  ARG   n 
1 40  PRO   n 
1 41  SER   n 
1 42  GLY   n 
1 43  ASN   n 
1 44  SER   n 
1 45  SER   n 
1 46  SER   n 
1 47  GLY   n 
1 48  GLY   n 
1 49  LYS   n 
1 50  ASN   n 
1 51  GLY   n 
1 52  GLN   n 
1 53  GLY   n 
1 54  GLU   n 
1 55  PRO   n 
1 56  ALA   n 
1 57  ARG   n 
1 58  VAL   n 
1 59  ARG   n 
1 60  CYS   n 
1 61  SER   n 
1 62  HIS   n 
1 63  LEU   n 
1 64  LEU   n 
1 65  VAL   n 
1 66  LYS   n 
1 67  HIS   n 
1 68  SER   n 
1 69  GLN   n 
1 70  SER   n 
1 71  ARG   n 
1 72  ARG   n 
1 73  PRO   n 
1 74  SER   n 
1 75  SER   n 
1 76  TRP   n 
1 77  ARG   n 
1 78  GLN   n 
1 79  GLU   n 
1 80  LYS   n 
1 81  ILE   n 
1 82  THR   n 
1 83  ARG   n 
1 84  THR   n 
1 85  LYS   n 
1 86  GLU   n 
1 87  GLU   n 
1 88  ALA   n 
1 89  LEU   n 
1 90  GLU   n 
1 91  LEU   n 
1 92  ILE   n 
1 93  ASN   n 
1 94  GLY   n 
1 95  TYR   n 
1 96  ILE   n 
1 97  GLN   n 
1 98  LYS   n 
1 99  ILE   n 
1 100 LYS   n 
1 101 SER   n 
1 102 GLY   n 
1 103 GLU   n 
1 104 GLU   n 
1 105 ASP   n 
1 106 PHE   n 
1 107 GLU   n 
1 108 SER   n 
1 109 LEU   n 
1 110 ALA   n 
1 111 SER   n 
1 112 GLN   n 
1 113 PHE   n 
1 114 SER   n 
1 115 ASP   n 
1 116 CYS   n 
1 117 SER   n 
1 118 SER   n 
1 119 ALA   n 
1 120 LYS   n 
1 121 ALA   n 
1 122 ARG   n 
1 123 GLY   n 
1 124 ASP   n 
1 125 LEU   n 
1 126 GLY   n 
1 127 ALA   n 
1 128 PHE   n 
1 129 SER   n 
1 130 ARG   n 
1 131 GLY   n 
1 132 GLN   n 
1 133 MET   n 
1 134 GLN   n 
1 135 LYS   n 
1 136 PRO   n 
1 137 PHE   n 
1 138 GLU   n 
1 139 ASP   n 
1 140 ALA   n 
1 141 SER   n 
1 142 PHE   n 
1 143 ALA   n 
1 144 LEU   n 
1 145 ARG   n 
1 146 THR   n 
1 147 GLY   n 
1 148 GLU   n 
1 149 MET   n 
1 150 SER   n 
1 151 GLY   n 
1 152 PRO   n 
1 153 VAL   n 
1 154 PHE   n 
1 155 THR   n 
1 156 ASP   n 
1 157 SER   n 
1 158 GLY   n 
1 159 ILE   n 
1 160 HIS   n 
1 161 ILE   n 
1 162 ILE   n 
1 163 LEU   n 
1 164 ARG   n 
1 165 THR   n 
1 166 GLU   n 
2 1   ACE   n 
2 2   PHE   n 
2 3   YCP   n 
2 4   A1A2Y n 
2 5   NH2   n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   166 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PIN1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       5 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1A2Y non-polymer         n 5-methoxy-L-tryptophan                  ?                              'C12 H14 N2 O3'  234.251 
ACE   non-polymer         . 'ACETYL GROUP'                          ?                              'C2 H4 O'        44.053  
ALA   'L-peptide linking' y ALANINE                                 ?                              'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                ?                              'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                              ?                              'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                         ?                              'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE                                ?                              'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE                               ?                              'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                         ?                              'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                 ?                              'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                               ?                              'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                   ?                              'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                              ?                              'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                 ?                              'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                  ?                              'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                              ?                              'C5 H11 N O2 S'  149.211 
NH2   non-polymer         . 'AMINO GROUP'                           ?                              'H2 N'           16.023  
P33   non-polymer         . 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL 'HEPTAETHYLENE GLYCOL; PEG330' 'C14 H30 O8'     326.383 
PHE   'L-peptide linking' y PHENYLALANINE                           ?                              'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                                 ?                              'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                  ?                              'C3 H7 N O3'     105.093 
SO4   non-polymer         . 'SULFATE ION'                           ?                              'O4 S -2'        96.063  
THR   'L-peptide linking' y THREONINE                               ?                              'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                              ?                              'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                ?                              'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                  ?                              'C5 H11 N O2'    117.146 
YCP   'L-peptide linking' . '(2S)-piperidine-2-carboxylic acid'     ?                              'C6 H11 N O2'    129.157 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY   1   -2  ?   ?     ?   A . n 
A 1 2   SER   2   -1  ?   ?     ?   A . n 
A 1 3   HIS   3   0   ?   ?     ?   A . n 
A 1 4   MET   4   1   ?   ?     ?   A . n 
A 1 5   ALA   5   2   ?   ?     ?   A . n 
A 1 6   ASP   6   3   ?   ?     ?   A . n 
A 1 7   GLU   7   4   ?   ?     ?   A . n 
A 1 8   GLU   8   5   ?   ?     ?   A . n 
A 1 9   LYS   9   6   ?   ?     ?   A . n 
A 1 10  LEU   10  7   7   LEU   LEU A . n 
A 1 11  PRO   11  8   8   PRO   PRO A . n 
A 1 12  PRO   12  9   9   PRO   PRO A . n 
A 1 13  GLY   13  10  10  GLY   GLY A . n 
A 1 14  TRP   14  11  11  TRP   TRP A . n 
A 1 15  GLU   15  12  12  GLU   GLU A . n 
A 1 16  LYS   16  13  13  LYS   LYS A . n 
A 1 17  ALA   17  14  14  ALA   ALA A . n 
A 1 18  MET   18  15  15  MET   MET A . n 
A 1 19  SER   19  16  16  SER   SER A . n 
A 1 20  ARG   20  17  17  ARG   ARG A . n 
A 1 21  SER   21  18  18  SER   SER A . n 
A 1 22  SER   22  19  19  SER   SER A . n 
A 1 23  GLY   23  20  20  GLY   GLY A . n 
A 1 24  ARG   24  21  21  ARG   ARG A . n 
A 1 25  VAL   25  22  22  VAL   VAL A . n 
A 1 26  TYR   26  23  23  TYR   TYR A . n 
A 1 27  TYR   27  24  24  TYR   TYR A . n 
A 1 28  PHE   28  25  25  PHE   PHE A . n 
A 1 29  ASN   29  26  26  ASN   ASN A . n 
A 1 30  HIS   30  27  27  HIS   HIS A . n 
A 1 31  ILE   31  28  28  ILE   ILE A . n 
A 1 32  THR   32  29  29  THR   THR A . n 
A 1 33  ASN   33  30  30  ASN   ASN A . n 
A 1 34  ALA   34  31  31  ALA   ALA A . n 
A 1 35  SER   35  32  32  SER   SER A . n 
A 1 36  GLN   36  33  33  GLN   GLN A . n 
A 1 37  TRP   37  34  34  TRP   TRP A . n 
A 1 38  GLU   38  35  35  GLU   GLU A . n 
A 1 39  ARG   39  36  36  ARG   ARG A . n 
A 1 40  PRO   40  37  37  PRO   PRO A . n 
A 1 41  SER   41  38  38  SER   SER A . n 
A 1 42  GLY   42  39  ?   ?     ?   A . n 
A 1 43  ASN   43  40  ?   ?     ?   A . n 
A 1 44  SER   44  41  ?   ?     ?   A . n 
A 1 45  SER   45  42  ?   ?     ?   A . n 
A 1 46  SER   46  43  ?   ?     ?   A . n 
A 1 47  GLY   47  44  ?   ?     ?   A . n 
A 1 48  GLY   48  45  ?   ?     ?   A . n 
A 1 49  LYS   49  46  ?   ?     ?   A . n 
A 1 50  ASN   50  47  ?   ?     ?   A . n 
A 1 51  GLY   51  48  ?   ?     ?   A . n 
A 1 52  GLN   52  49  ?   ?     ?   A . n 
A 1 53  GLY   53  50  ?   ?     ?   A . n 
A 1 54  GLU   54  51  51  GLU   GLU A . n 
A 1 55  PRO   55  52  52  PRO   PRO A . n 
A 1 56  ALA   56  53  53  ALA   ALA A . n 
A 1 57  ARG   57  54  54  ARG   ARG A . n 
A 1 58  VAL   58  55  55  VAL   VAL A . n 
A 1 59  ARG   59  56  56  ARG   ARG A . n 
A 1 60  CYS   60  57  57  CYS   CYS A . n 
A 1 61  SER   61  58  58  SER   SER A . n 
A 1 62  HIS   62  59  59  HIS   HIS A . n 
A 1 63  LEU   63  60  60  LEU   LEU A . n 
A 1 64  LEU   64  61  61  LEU   LEU A . n 
A 1 65  VAL   65  62  62  VAL   VAL A . n 
A 1 66  LYS   66  63  63  LYS   LYS A . n 
A 1 67  HIS   67  64  64  HIS   HIS A . n 
A 1 68  SER   68  65  65  SER   SER A . n 
A 1 69  GLN   69  66  66  GLN   GLN A . n 
A 1 70  SER   70  67  67  SER   SER A . n 
A 1 71  ARG   71  68  68  ARG   ARG A . n 
A 1 72  ARG   72  69  69  ARG   ARG A . n 
A 1 73  PRO   73  70  70  PRO   PRO A . n 
A 1 74  SER   74  71  71  SER   SER A . n 
A 1 75  SER   75  72  72  SER   SER A . n 
A 1 76  TRP   76  73  73  TRP   TRP A . n 
A 1 77  ARG   77  74  74  ARG   ARG A . n 
A 1 78  GLN   78  75  75  GLN   GLN A . n 
A 1 79  GLU   79  76  76  GLU   GLU A . n 
A 1 80  LYS   80  77  77  LYS   LYS A . n 
A 1 81  ILE   81  78  78  ILE   ILE A . n 
A 1 82  THR   82  79  79  THR   THR A . n 
A 1 83  ARG   83  80  80  ARG   ARG A . n 
A 1 84  THR   84  81  81  THR   THR A . n 
A 1 85  LYS   85  82  82  LYS   LYS A . n 
A 1 86  GLU   86  83  83  GLU   GLU A . n 
A 1 87  GLU   87  84  84  GLU   GLU A . n 
A 1 88  ALA   88  85  85  ALA   ALA A . n 
A 1 89  LEU   89  86  86  LEU   LEU A . n 
A 1 90  GLU   90  87  87  GLU   GLU A . n 
A 1 91  LEU   91  88  88  LEU   LEU A . n 
A 1 92  ILE   92  89  89  ILE   ILE A . n 
A 1 93  ASN   93  90  90  ASN   ASN A . n 
A 1 94  GLY   94  91  91  GLY   GLY A . n 
A 1 95  TYR   95  92  92  TYR   TYR A . n 
A 1 96  ILE   96  93  93  ILE   ILE A . n 
A 1 97  GLN   97  94  94  GLN   GLN A . n 
A 1 98  LYS   98  95  95  LYS   LYS A . n 
A 1 99  ILE   99  96  96  ILE   ILE A . n 
A 1 100 LYS   100 97  97  LYS   LYS A . n 
A 1 101 SER   101 98  98  SER   SER A . n 
A 1 102 GLY   102 99  99  GLY   GLY A . n 
A 1 103 GLU   103 100 100 GLU   GLU A . n 
A 1 104 GLU   104 101 101 GLU   GLU A . n 
A 1 105 ASP   105 102 102 ASP   ASP A . n 
A 1 106 PHE   106 103 103 PHE   PHE A . n 
A 1 107 GLU   107 104 104 GLU   GLU A . n 
A 1 108 SER   108 105 105 SER   SER A . n 
A 1 109 LEU   109 106 106 LEU   LEU A . n 
A 1 110 ALA   110 107 107 ALA   ALA A . n 
A 1 111 SER   111 108 108 SER   SER A . n 
A 1 112 GLN   112 109 109 GLN   GLN A . n 
A 1 113 PHE   113 110 110 PHE   PHE A . n 
A 1 114 SER   114 111 111 SER   SER A . n 
A 1 115 ASP   115 112 112 ASP   ASP A . n 
A 1 116 CYS   116 113 113 CYS   CYS A . n 
A 1 117 SER   117 114 114 SER   SER A . n 
A 1 118 SER   118 115 115 SER   SER A . n 
A 1 119 ALA   119 116 116 ALA   ALA A . n 
A 1 120 LYS   120 117 117 LYS   LYS A . n 
A 1 121 ALA   121 118 118 ALA   ALA A . n 
A 1 122 ARG   122 119 119 ARG   ARG A . n 
A 1 123 GLY   123 120 120 GLY   GLY A . n 
A 1 124 ASP   124 121 121 ASP   ASP A . n 
A 1 125 LEU   125 122 122 LEU   LEU A . n 
A 1 126 GLY   126 123 123 GLY   GLY A . n 
A 1 127 ALA   127 124 124 ALA   ALA A . n 
A 1 128 PHE   128 125 125 PHE   PHE A . n 
A 1 129 SER   129 126 126 SER   SER A . n 
A 1 130 ARG   130 127 127 ARG   ARG A . n 
A 1 131 GLY   131 128 128 GLY   GLY A . n 
A 1 132 GLN   132 129 129 GLN   GLN A . n 
A 1 133 MET   133 130 130 MET   MET A . n 
A 1 134 GLN   134 131 131 GLN   GLN A . n 
A 1 135 LYS   135 132 132 LYS   LYS A . n 
A 1 136 PRO   136 133 133 PRO   PRO A . n 
A 1 137 PHE   137 134 134 PHE   PHE A . n 
A 1 138 GLU   138 135 135 GLU   GLU A . n 
A 1 139 ASP   139 136 136 ASP   ASP A . n 
A 1 140 ALA   140 137 137 ALA   ALA A . n 
A 1 141 SER   141 138 138 SER   SER A . n 
A 1 142 PHE   142 139 139 PHE   PHE A . n 
A 1 143 ALA   143 140 140 ALA   ALA A . n 
A 1 144 LEU   144 141 141 LEU   LEU A . n 
A 1 145 ARG   145 142 142 ARG   ARG A . n 
A 1 146 THR   146 143 143 THR   THR A . n 
A 1 147 GLY   147 144 144 GLY   GLY A . n 
A 1 148 GLU   148 145 145 GLU   GLU A . n 
A 1 149 MET   149 146 146 MET   MET A . n 
A 1 150 SER   150 147 147 SER   SER A . n 
A 1 151 GLY   151 148 148 GLY   GLY A . n 
A 1 152 PRO   152 149 149 PRO   PRO A . n 
A 1 153 VAL   153 150 150 VAL   VAL A . n 
A 1 154 PHE   154 151 151 PHE   PHE A . n 
A 1 155 THR   155 152 152 THR   THR A . n 
A 1 156 ASP   156 153 153 ASP   ASP A . n 
A 1 157 SER   157 154 154 SER   SER A . n 
A 1 158 GLY   158 155 155 GLY   GLY A . n 
A 1 159 ILE   159 156 156 ILE   ILE A . n 
A 1 160 HIS   160 157 157 HIS   HIS A . n 
A 1 161 ILE   161 158 158 ILE   ILE A . n 
A 1 162 ILE   162 159 159 ILE   ILE A . n 
A 1 163 LEU   163 160 160 LEU   LEU A . n 
A 1 164 ARG   164 161 161 ARG   ARG A . n 
A 1 165 THR   165 162 162 THR   THR A . n 
A 1 166 GLU   166 163 163 GLU   GLU A . n 
B 1 1   GLY   1   -2  ?   ?     ?   B . n 
B 1 2   SER   2   -1  ?   ?     ?   B . n 
B 1 3   HIS   3   0   ?   ?     ?   B . n 
B 1 4   MET   4   1   ?   ?     ?   B . n 
B 1 5   ALA   5   2   ?   ?     ?   B . n 
B 1 6   ASP   6   3   ?   ?     ?   B . n 
B 1 7   GLU   7   4   ?   ?     ?   B . n 
B 1 8   GLU   8   5   ?   ?     ?   B . n 
B 1 9   LYS   9   6   ?   ?     ?   B . n 
B 1 10  LEU   10  7   7   LEU   LEU B . n 
B 1 11  PRO   11  8   8   PRO   PRO B . n 
B 1 12  PRO   12  9   9   PRO   PRO B . n 
B 1 13  GLY   13  10  10  GLY   GLY B . n 
B 1 14  TRP   14  11  11  TRP   TRP B . n 
B 1 15  GLU   15  12  12  GLU   GLU B . n 
B 1 16  LYS   16  13  13  LYS   LYS B . n 
B 1 17  ALA   17  14  14  ALA   ALA B . n 
B 1 18  MET   18  15  15  MET   MET B . n 
B 1 19  SER   19  16  16  SER   SER B . n 
B 1 20  ARG   20  17  17  ARG   ARG B . n 
B 1 21  SER   21  18  18  SER   SER B . n 
B 1 22  SER   22  19  19  SER   SER B . n 
B 1 23  GLY   23  20  20  GLY   GLY B . n 
B 1 24  ARG   24  21  21  ARG   ARG B . n 
B 1 25  VAL   25  22  22  VAL   VAL B . n 
B 1 26  TYR   26  23  23  TYR   TYR B . n 
B 1 27  TYR   27  24  24  TYR   TYR B . n 
B 1 28  PHE   28  25  25  PHE   PHE B . n 
B 1 29  ASN   29  26  26  ASN   ASN B . n 
B 1 30  HIS   30  27  27  HIS   HIS B . n 
B 1 31  ILE   31  28  28  ILE   ILE B . n 
B 1 32  THR   32  29  29  THR   THR B . n 
B 1 33  ASN   33  30  30  ASN   ASN B . n 
B 1 34  ALA   34  31  31  ALA   ALA B . n 
B 1 35  SER   35  32  32  SER   SER B . n 
B 1 36  GLN   36  33  33  GLN   GLN B . n 
B 1 37  TRP   37  34  34  TRP   TRP B . n 
B 1 38  GLU   38  35  35  GLU   GLU B . n 
B 1 39  ARG   39  36  36  ARG   ARG B . n 
B 1 40  PRO   40  37  37  PRO   PRO B . n 
B 1 41  SER   41  38  38  SER   SER B . n 
B 1 42  GLY   42  39  ?   ?     ?   B . n 
B 1 43  ASN   43  40  ?   ?     ?   B . n 
B 1 44  SER   44  41  ?   ?     ?   B . n 
B 1 45  SER   45  42  ?   ?     ?   B . n 
B 1 46  SER   46  43  ?   ?     ?   B . n 
B 1 47  GLY   47  44  ?   ?     ?   B . n 
B 1 48  GLY   48  45  ?   ?     ?   B . n 
B 1 49  LYS   49  46  ?   ?     ?   B . n 
B 1 50  ASN   50  47  ?   ?     ?   B . n 
B 1 51  GLY   51  48  ?   ?     ?   B . n 
B 1 52  GLN   52  49  ?   ?     ?   B . n 
B 1 53  GLY   53  50  ?   ?     ?   B . n 
B 1 54  GLU   54  51  51  GLU   GLU B . n 
B 1 55  PRO   55  52  52  PRO   PRO B . n 
B 1 56  ALA   56  53  53  ALA   ALA B . n 
B 1 57  ARG   57  54  54  ARG   ARG B . n 
B 1 58  VAL   58  55  55  VAL   VAL B . n 
B 1 59  ARG   59  56  56  ARG   ARG B . n 
B 1 60  CYS   60  57  57  CYS   CYS B . n 
B 1 61  SER   61  58  58  SER   SER B . n 
B 1 62  HIS   62  59  59  HIS   HIS B . n 
B 1 63  LEU   63  60  60  LEU   LEU B . n 
B 1 64  LEU   64  61  61  LEU   LEU B . n 
B 1 65  VAL   65  62  62  VAL   VAL B . n 
B 1 66  LYS   66  63  63  LYS   LYS B . n 
B 1 67  HIS   67  64  64  HIS   HIS B . n 
B 1 68  SER   68  65  65  SER   SER B . n 
B 1 69  GLN   69  66  66  GLN   GLN B . n 
B 1 70  SER   70  67  67  SER   SER B . n 
B 1 71  ARG   71  68  68  ARG   ARG B . n 
B 1 72  ARG   72  69  69  ARG   ARG B . n 
B 1 73  PRO   73  70  70  PRO   PRO B . n 
B 1 74  SER   74  71  71  SER   SER B . n 
B 1 75  SER   75  72  72  SER   SER B . n 
B 1 76  TRP   76  73  73  TRP   TRP B . n 
B 1 77  ARG   77  74  74  ARG   ARG B . n 
B 1 78  GLN   78  75  75  GLN   GLN B . n 
B 1 79  GLU   79  76  76  GLU   GLU B . n 
B 1 80  LYS   80  77  77  LYS   LYS B . n 
B 1 81  ILE   81  78  78  ILE   ILE B . n 
B 1 82  THR   82  79  79  THR   THR B . n 
B 1 83  ARG   83  80  80  ARG   ARG B . n 
B 1 84  THR   84  81  81  THR   THR B . n 
B 1 85  LYS   85  82  82  LYS   LYS B . n 
B 1 86  GLU   86  83  83  GLU   GLU B . n 
B 1 87  GLU   87  84  84  GLU   GLU B . n 
B 1 88  ALA   88  85  85  ALA   ALA B . n 
B 1 89  LEU   89  86  86  LEU   LEU B . n 
B 1 90  GLU   90  87  87  GLU   GLU B . n 
B 1 91  LEU   91  88  88  LEU   LEU B . n 
B 1 92  ILE   92  89  89  ILE   ILE B . n 
B 1 93  ASN   93  90  90  ASN   ASN B . n 
B 1 94  GLY   94  91  91  GLY   GLY B . n 
B 1 95  TYR   95  92  92  TYR   TYR B . n 
B 1 96  ILE   96  93  93  ILE   ILE B . n 
B 1 97  GLN   97  94  94  GLN   GLN B . n 
B 1 98  LYS   98  95  95  LYS   LYS B . n 
B 1 99  ILE   99  96  96  ILE   ILE B . n 
B 1 100 LYS   100 97  97  LYS   LYS B . n 
B 1 101 SER   101 98  98  SER   SER B . n 
B 1 102 GLY   102 99  99  GLY   GLY B . n 
B 1 103 GLU   103 100 100 GLU   GLU B . n 
B 1 104 GLU   104 101 101 GLU   GLU B . n 
B 1 105 ASP   105 102 102 ASP   ASP B . n 
B 1 106 PHE   106 103 103 PHE   PHE B . n 
B 1 107 GLU   107 104 104 GLU   GLU B . n 
B 1 108 SER   108 105 105 SER   SER B . n 
B 1 109 LEU   109 106 106 LEU   LEU B . n 
B 1 110 ALA   110 107 107 ALA   ALA B . n 
B 1 111 SER   111 108 108 SER   SER B . n 
B 1 112 GLN   112 109 109 GLN   GLN B . n 
B 1 113 PHE   113 110 110 PHE   PHE B . n 
B 1 114 SER   114 111 111 SER   SER B . n 
B 1 115 ASP   115 112 112 ASP   ASP B . n 
B 1 116 CYS   116 113 113 CYS   CYS B . n 
B 1 117 SER   117 114 114 SER   SER B . n 
B 1 118 SER   118 115 115 SER   SER B . n 
B 1 119 ALA   119 116 116 ALA   ALA B . n 
B 1 120 LYS   120 117 117 LYS   LYS B . n 
B 1 121 ALA   121 118 118 ALA   ALA B . n 
B 1 122 ARG   122 119 119 ARG   ARG B . n 
B 1 123 GLY   123 120 120 GLY   GLY B . n 
B 1 124 ASP   124 121 121 ASP   ASP B . n 
B 1 125 LEU   125 122 122 LEU   LEU B . n 
B 1 126 GLY   126 123 123 GLY   GLY B . n 
B 1 127 ALA   127 124 124 ALA   ALA B . n 
B 1 128 PHE   128 125 125 PHE   PHE B . n 
B 1 129 SER   129 126 126 SER   SER B . n 
B 1 130 ARG   130 127 127 ARG   ARG B . n 
B 1 131 GLY   131 128 128 GLY   GLY B . n 
B 1 132 GLN   132 129 129 GLN   GLN B . n 
B 1 133 MET   133 130 130 MET   MET B . n 
B 1 134 GLN   134 131 131 GLN   GLN B . n 
B 1 135 LYS   135 132 132 LYS   LYS B . n 
B 1 136 PRO   136 133 133 PRO   PRO B . n 
B 1 137 PHE   137 134 134 PHE   PHE B . n 
B 1 138 GLU   138 135 135 GLU   GLU B . n 
B 1 139 ASP   139 136 136 ASP   ASP B . n 
B 1 140 ALA   140 137 137 ALA   ALA B . n 
B 1 141 SER   141 138 138 SER   SER B . n 
B 1 142 PHE   142 139 139 PHE   PHE B . n 
B 1 143 ALA   143 140 140 ALA   ALA B . n 
B 1 144 LEU   144 141 141 LEU   LEU B . n 
B 1 145 ARG   145 142 142 ARG   ARG B . n 
B 1 146 THR   146 143 143 THR   THR B . n 
B 1 147 GLY   147 144 144 GLY   GLY B . n 
B 1 148 GLU   148 145 145 GLU   GLU B . n 
B 1 149 MET   149 146 146 MET   MET B . n 
B 1 150 SER   150 147 147 SER   SER B . n 
B 1 151 GLY   151 148 148 GLY   GLY B . n 
B 1 152 PRO   152 149 149 PRO   PRO B . n 
B 1 153 VAL   153 150 150 VAL   VAL B . n 
B 1 154 PHE   154 151 151 PHE   PHE B . n 
B 1 155 THR   155 152 152 THR   THR B . n 
B 1 156 ASP   156 153 153 ASP   ASP B . n 
B 1 157 SER   157 154 154 SER   SER B . n 
B 1 158 GLY   158 155 155 GLY   GLY B . n 
B 1 159 ILE   159 156 156 ILE   ILE B . n 
B 1 160 HIS   160 157 157 HIS   HIS B . n 
B 1 161 ILE   161 158 158 ILE   ILE B . n 
B 1 162 ILE   162 159 159 ILE   ILE B . n 
B 1 163 LEU   163 160 160 LEU   LEU B . n 
B 1 164 ARG   164 161 161 ARG   ARG B . n 
B 1 165 THR   165 162 162 THR   THR B . n 
B 1 166 GLU   166 163 163 GLU   GLU B . n 
C 2 1   ACE   1   1   201 ACE   INH C . n 
C 2 2   PHE   2   2   201 PHE   INH C . n 
C 2 3   YCP   3   3   201 YCP   INH C . n 
C 2 4   A1A2Y 4   4   201 A1A2Y INH C . n 
C 2 5   NH2   5   5   201 NH2   INH C . n 
D 2 1   ACE   1   1   201 ACE   INH D . n 
D 2 2   PHE   2   2   201 PHE   INH D . n 
D 2 3   YCP   3   3   201 YCP   INH D . n 
D 2 4   A1A2Y 4   4   201 A1A2Y INH D . n 
D 2 5   NH2   5   5   201 NH2   INH D . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 A1A2Y ? ? A1A2Y ? ? 'SUBJECT OF INVESTIGATION' ? 
2 YCP   ? ? YCP   ? ? 'SUBJECT OF INVESTIGATION' ? 
3 ACE   ? ? ACE   ? ? 'SUBJECT OF INVESTIGATION' ? 
4 NH2   ? ? NH2   ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 P33 1   201 304 P33 PEG A . 
F 4 SO4 1   202 2   SO4 SO4 A . 
G 4 SO4 1   203 30  SO4 SO4 A . 
H 4 SO4 1   204 31  SO4 SO4 A . 
I 4 SO4 1   205 32  SO4 SO4 A . 
J 4 SO4 1   206 38  SO4 SO4 A . 
K 4 SO4 1   207 41  SO4 SO4 A . 
L 3 P33 1   301 301 P33 PEG B . 
M 4 SO4 1   302 33  SO4 SO4 B . 
N 4 SO4 1   303 35  SO4 SO4 B . 
O 4 SO4 1   304 40  SO4 SO4 B . 
P 5 HOH 1   301 298 HOH HOH A . 
P 5 HOH 2   302 299 HOH HOH A . 
P 5 HOH 3   303 257 HOH HOH A . 
P 5 HOH 4   304 263 HOH HOH A . 
P 5 HOH 5   305 208 HOH HOH A . 
P 5 HOH 6   306 256 HOH HOH A . 
P 5 HOH 7   307 309 HOH HOH A . 
P 5 HOH 8   308 167 HOH HOH A . 
P 5 HOH 9   309 60  HOH HOH A . 
P 5 HOH 10  310 353 HOH HOH A . 
P 5 HOH 11  311 44  HOH HOH A . 
P 5 HOH 12  312 290 HOH HOH A . 
P 5 HOH 13  313 34  HOH HOH A . 
P 5 HOH 14  314 83  HOH HOH A . 
P 5 HOH 15  315 316 HOH HOH A . 
P 5 HOH 16  316 36  HOH HOH A . 
P 5 HOH 17  317 368 HOH HOH A . 
P 5 HOH 18  318 40  HOH HOH A . 
P 5 HOH 19  319 311 HOH HOH A . 
P 5 HOH 20  320 278 HOH HOH A . 
P 5 HOH 21  321 203 HOH HOH A . 
P 5 HOH 22  322 313 HOH HOH A . 
P 5 HOH 23  323 10  HOH HOH A . 
P 5 HOH 24  324 288 HOH HOH A . 
P 5 HOH 25  325 65  HOH HOH A . 
P 5 HOH 26  326 372 HOH HOH A . 
P 5 HOH 27  327 140 HOH HOH A . 
P 5 HOH 28  328 84  HOH HOH A . 
P 5 HOH 29  329 212 HOH HOH A . 
P 5 HOH 30  330 141 HOH HOH A . 
P 5 HOH 31  331 122 HOH HOH A . 
P 5 HOH 32  332 119 HOH HOH A . 
P 5 HOH 33  333 287 HOH HOH A . 
P 5 HOH 34  334 99  HOH HOH A . 
P 5 HOH 35  335 253 HOH HOH A . 
P 5 HOH 36  336 46  HOH HOH A . 
P 5 HOH 37  337 110 HOH HOH A . 
P 5 HOH 38  338 275 HOH HOH A . 
P 5 HOH 39  339 226 HOH HOH A . 
P 5 HOH 40  340 32  HOH HOH A . 
P 5 HOH 41  341 73  HOH HOH A . 
P 5 HOH 42  342 45  HOH HOH A . 
P 5 HOH 43  343 61  HOH HOH A . 
P 5 HOH 44  344 131 HOH HOH A . 
P 5 HOH 45  345 244 HOH HOH A . 
P 5 HOH 46  346 306 HOH HOH A . 
P 5 HOH 47  347 148 HOH HOH A . 
P 5 HOH 48  348 112 HOH HOH A . 
P 5 HOH 49  349 300 HOH HOH A . 
P 5 HOH 50  350 31  HOH HOH A . 
P 5 HOH 51  351 280 HOH HOH A . 
P 5 HOH 52  352 116 HOH HOH A . 
P 5 HOH 53  353 28  HOH HOH A . 
P 5 HOH 54  354 229 HOH HOH A . 
P 5 HOH 55  355 129 HOH HOH A . 
P 5 HOH 56  356 242 HOH HOH A . 
P 5 HOH 57  357 88  HOH HOH A . 
P 5 HOH 58  358 310 HOH HOH A . 
P 5 HOH 59  359 41  HOH HOH A . 
P 5 HOH 60  360 53  HOH HOH A . 
P 5 HOH 61  361 97  HOH HOH A . 
P 5 HOH 62  362 202 HOH HOH A . 
P 5 HOH 63  363 262 HOH HOH A . 
P 5 HOH 64  364 158 HOH HOH A . 
P 5 HOH 65  365 95  HOH HOH A . 
P 5 HOH 66  366 215 HOH HOH A . 
P 5 HOH 67  367 317 HOH HOH A . 
P 5 HOH 68  368 155 HOH HOH A . 
P 5 HOH 69  369 33  HOH HOH A . 
P 5 HOH 70  370 301 HOH HOH A . 
P 5 HOH 71  371 254 HOH HOH A . 
P 5 HOH 72  372 90  HOH HOH A . 
P 5 HOH 73  373 66  HOH HOH A . 
P 5 HOH 74  374 111 HOH HOH A . 
P 5 HOH 75  375 70  HOH HOH A . 
P 5 HOH 76  376 230 HOH HOH A . 
P 5 HOH 77  377 144 HOH HOH A . 
P 5 HOH 78  378 35  HOH HOH A . 
P 5 HOH 79  379 48  HOH HOH A . 
P 5 HOH 80  380 30  HOH HOH A . 
P 5 HOH 81  381 211 HOH HOH A . 
P 5 HOH 82  382 92  HOH HOH A . 
P 5 HOH 83  383 93  HOH HOH A . 
P 5 HOH 84  384 272 HOH HOH A . 
P 5 HOH 85  385 260 HOH HOH A . 
P 5 HOH 86  386 239 HOH HOH A . 
P 5 HOH 87  387 142 HOH HOH A . 
P 5 HOH 88  388 163 HOH HOH A . 
P 5 HOH 89  389 94  HOH HOH A . 
P 5 HOH 90  390 217 HOH HOH A . 
P 5 HOH 91  391 293 HOH HOH A . 
P 5 HOH 92  392 277 HOH HOH A . 
P 5 HOH 93  393 98  HOH HOH A . 
P 5 HOH 94  394 157 HOH HOH A . 
P 5 HOH 95  395 347 HOH HOH A . 
P 5 HOH 96  396 374 HOH HOH A . 
P 5 HOH 97  397 320 HOH HOH A . 
P 5 HOH 98  398 164 HOH HOH A . 
P 5 HOH 99  399 113 HOH HOH A . 
P 5 HOH 100 400 296 HOH HOH A . 
P 5 HOH 101 401 124 HOH HOH A . 
P 5 HOH 102 402 139 HOH HOH A . 
P 5 HOH 103 403 335 HOH HOH A . 
P 5 HOH 104 404 71  HOH HOH A . 
P 5 HOH 105 405 267 HOH HOH A . 
P 5 HOH 106 406 121 HOH HOH A . 
P 5 HOH 107 407 378 HOH HOH A . 
P 5 HOH 108 408 247 HOH HOH A . 
P 5 HOH 109 409 304 HOH HOH A . 
P 5 HOH 110 410 314 HOH HOH A . 
P 5 HOH 111 411 307 HOH HOH A . 
P 5 HOH 112 412 292 HOH HOH A . 
P 5 HOH 113 413 319 HOH HOH A . 
P 5 HOH 114 414 100 HOH HOH A . 
P 5 HOH 115 415 373 HOH HOH A . 
P 5 HOH 116 416 370 HOH HOH A . 
P 5 HOH 117 417 240 HOH HOH A . 
P 5 HOH 118 418 354 HOH HOH A . 
P 5 HOH 119 419 266 HOH HOH A . 
P 5 HOH 120 420 91  HOH HOH A . 
P 5 HOH 121 421 276 HOH HOH A . 
P 5 HOH 122 422 294 HOH HOH A . 
P 5 HOH 123 423 362 HOH HOH A . 
P 5 HOH 124 424 175 HOH HOH A . 
P 5 HOH 125 425 79  HOH HOH A . 
P 5 HOH 126 426 361 HOH HOH A . 
P 5 HOH 127 427 143 HOH HOH A . 
P 5 HOH 128 428 312 HOH HOH A . 
P 5 HOH 129 429 231 HOH HOH A . 
P 5 HOH 130 430 120 HOH HOH A . 
P 5 HOH 131 431 291 HOH HOH A . 
P 5 HOH 132 432 315 HOH HOH A . 
P 5 HOH 133 433 270 HOH HOH A . 
P 5 HOH 134 434 130 HOH HOH A . 
P 5 HOH 135 435 271 HOH HOH A . 
P 5 HOH 136 436 289 HOH HOH A . 
P 5 HOH 137 437 196 HOH HOH A . 
P 5 HOH 138 438 103 HOH HOH A . 
P 5 HOH 139 439 136 HOH HOH A . 
P 5 HOH 140 440 305 HOH HOH A . 
P 5 HOH 141 441 152 HOH HOH A . 
P 5 HOH 142 442 351 HOH HOH A . 
P 5 HOH 143 443 258 HOH HOH A . 
P 5 HOH 144 444 269 HOH HOH A . 
P 5 HOH 145 445 375 HOH HOH A . 
P 5 HOH 146 446 321 HOH HOH A . 
P 5 HOH 147 447 221 HOH HOH A . 
P 5 HOH 148 448 371 HOH HOH A . 
P 5 HOH 149 449 295 HOH HOH A . 
Q 5 HOH 1   401 333 HOH HOH B . 
Q 5 HOH 2   402 134 HOH HOH B . 
Q 5 HOH 3   403 336 HOH HOH B . 
Q 5 HOH 4   404 303 HOH HOH B . 
Q 5 HOH 5   405 189 HOH HOH B . 
Q 5 HOH 6   406 332 HOH HOH B . 
Q 5 HOH 7   407 180 HOH HOH B . 
Q 5 HOH 8   408 57  HOH HOH B . 
Q 5 HOH 9   409 178 HOH HOH B . 
Q 5 HOH 10  410 356 HOH HOH B . 
Q 5 HOH 11  411 340 HOH HOH B . 
Q 5 HOH 12  412 177 HOH HOH B . 
Q 5 HOH 13  413 181 HOH HOH B . 
Q 5 HOH 14  414 265 HOH HOH B . 
Q 5 HOH 15  415 2   HOH HOH B . 
Q 5 HOH 16  416 160 HOH HOH B . 
Q 5 HOH 17  417 22  HOH HOH B . 
Q 5 HOH 18  418 200 HOH HOH B . 
Q 5 HOH 19  419 328 HOH HOH B . 
Q 5 HOH 20  420 194 HOH HOH B . 
Q 5 HOH 21  421 232 HOH HOH B . 
Q 5 HOH 22  422 201 HOH HOH B . 
Q 5 HOH 23  423 224 HOH HOH B . 
Q 5 HOH 24  424 4   HOH HOH B . 
Q 5 HOH 25  425 166 HOH HOH B . 
Q 5 HOH 26  426 207 HOH HOH B . 
Q 5 HOH 27  427 281 HOH HOH B . 
Q 5 HOH 28  428 322 HOH HOH B . 
Q 5 HOH 29  429 118 HOH HOH B . 
Q 5 HOH 30  430 162 HOH HOH B . 
Q 5 HOH 31  431 195 HOH HOH B . 
Q 5 HOH 32  432 297 HOH HOH B . 
Q 5 HOH 33  433 25  HOH HOH B . 
Q 5 HOH 34  434 176 HOH HOH B . 
Q 5 HOH 35  435 6   HOH HOH B . 
Q 5 HOH 36  436 334 HOH HOH B . 
Q 5 HOH 37  437 357 HOH HOH B . 
Q 5 HOH 38  438 227 HOH HOH B . 
Q 5 HOH 39  439 74  HOH HOH B . 
Q 5 HOH 40  440 228 HOH HOH B . 
Q 5 HOH 41  441 56  HOH HOH B . 
Q 5 HOH 42  442 19  HOH HOH B . 
Q 5 HOH 43  443 1   HOH HOH B . 
Q 5 HOH 44  444 54  HOH HOH B . 
Q 5 HOH 45  445 249 HOH HOH B . 
Q 5 HOH 46  446 64  HOH HOH B . 
Q 5 HOH 47  447 146 HOH HOH B . 
Q 5 HOH 48  448 209 HOH HOH B . 
Q 5 HOH 49  449 105 HOH HOH B . 
Q 5 HOH 50  450 26  HOH HOH B . 
Q 5 HOH 51  451 338 HOH HOH B . 
Q 5 HOH 52  452 186 HOH HOH B . 
Q 5 HOH 53  453 308 HOH HOH B . 
Q 5 HOH 54  454 7   HOH HOH B . 
Q 5 HOH 55  455 15  HOH HOH B . 
Q 5 HOH 56  456 132 HOH HOH B . 
Q 5 HOH 57  457 62  HOH HOH B . 
Q 5 HOH 58  458 346 HOH HOH B . 
Q 5 HOH 59  459 199 HOH HOH B . 
Q 5 HOH 60  460 159 HOH HOH B . 
Q 5 HOH 61  461 145 HOH HOH B . 
Q 5 HOH 62  462 327 HOH HOH B . 
Q 5 HOH 63  463 137 HOH HOH B . 
Q 5 HOH 64  464 210 HOH HOH B . 
Q 5 HOH 65  465 63  HOH HOH B . 
Q 5 HOH 66  466 23  HOH HOH B . 
Q 5 HOH 67  467 117 HOH HOH B . 
Q 5 HOH 68  468 168 HOH HOH B . 
Q 5 HOH 69  469 366 HOH HOH B . 
Q 5 HOH 70  470 369 HOH HOH B . 
Q 5 HOH 71  471 106 HOH HOH B . 
Q 5 HOH 72  472 11  HOH HOH B . 
Q 5 HOH 73  473 58  HOH HOH B . 
Q 5 HOH 74  474 302 HOH HOH B . 
Q 5 HOH 75  475 169 HOH HOH B . 
Q 5 HOH 76  476 20  HOH HOH B . 
Q 5 HOH 77  477 9   HOH HOH B . 
Q 5 HOH 78  478 365 HOH HOH B . 
Q 5 HOH 79  479 183 HOH HOH B . 
Q 5 HOH 80  480 337 HOH HOH B . 
Q 5 HOH 81  481 358 HOH HOH B . 
Q 5 HOH 82  482 147 HOH HOH B . 
Q 5 HOH 83  483 339 HOH HOH B . 
Q 5 HOH 84  484 284 HOH HOH B . 
Q 5 HOH 85  485 198 HOH HOH B . 
Q 5 HOH 86  486 179 HOH HOH B . 
Q 5 HOH 87  487 182 HOH HOH B . 
Q 5 HOH 88  488 204 HOH HOH B . 
Q 5 HOH 89  489 379 HOH HOH B . 
Q 5 HOH 90  490 214 HOH HOH B . 
Q 5 HOH 91  491 324 HOH HOH B . 
Q 5 HOH 92  492 367 HOH HOH B . 
Q 5 HOH 93  493 377 HOH HOH B . 
Q 5 HOH 94  494 191 HOH HOH B . 
Q 5 HOH 95  495 364 HOH HOH B . 
Q 5 HOH 96  496 192 HOH HOH B . 
Q 5 HOH 97  497 29  HOH HOH B . 
Q 5 HOH 98  498 325 HOH HOH B . 
Q 5 HOH 99  499 233 HOH HOH B . 
Q 5 HOH 100 500 188 HOH HOH B . 
Q 5 HOH 101 501 225 HOH HOH B . 
Q 5 HOH 102 502 352 HOH HOH B . 
Q 5 HOH 103 503 24  HOH HOH B . 
Q 5 HOH 104 504 363 HOH HOH B . 
Q 5 HOH 105 505 326 HOH HOH B . 
Q 5 HOH 106 506 135 HOH HOH B . 
Q 5 HOH 107 507 187 HOH HOH B . 
Q 5 HOH 108 508 222 HOH HOH B . 
Q 5 HOH 109 509 283 HOH HOH B . 
R 5 HOH 1   101 165 HOH HOH C . 
R 5 HOH 2   102 50  HOH HOH C . 
R 5 HOH 3   103 47  HOH HOH C . 
S 5 HOH 1   101 5   HOH HOH D . 
S 5 HOH 2   102 133 HOH HOH D . 
S 5 HOH 3   103 285 HOH HOH D . 
S 5 HOH 4   104 286 HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? BOS     ? ? ? .           2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8VJD 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     60.000 
_cell.length_a_esd                 ? 
_cell.length_b                     62.030 
_cell.length_b_esd                 ? 
_cell.length_c                     93.410 
_cell.length_c_esd                 ? 
_cell.volume                       347653.338 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8VJD 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8VJD 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.13 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.38 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.9 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'HEPES-NaOH, Ammonium sulfate, PEG400, DTT' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 2M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9765 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.3' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9765 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.3 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          18.80 
_reflns.entry_id                                       8VJD 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.57 
_reflns.d_resolution_low                               46.71 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     49405 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          17.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.027 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.062 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.57 
_reflns_shell.d_res_low                                     1.60 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2375 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.304 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.629 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.25 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8VJD 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.57 
_refine.ls_d_res_low                             46.71 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     49343 
_refine.ls_number_reflns_R_free                  1990 
_refine.ls_number_reflns_R_work                  47353 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.91 
_refine.ls_percent_reflns_R_free                 4.03 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1995 
_refine.ls_R_factor_R_free                       0.2177 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1987 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.8208 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1658 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.57 
_refine_hist.d_res_low                        46.71 
_refine_hist.number_atoms_solvent             265 
_refine_hist.number_atoms_total               2742 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2310 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         167 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0059  ? 2549 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8615  ? 3415 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0520  ? 333  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0074  ? 434  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 18.0723 ? 963  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.57 1.61  . . 145 3289 99.42  . . . . 0.2507 . . . . . . . . . . . 0.2706 
'X-RAY DIFFRACTION' 1.61 1.65  . . 134 3337 100.00 . . . . 0.2179 . . . . . . . . . . . 0.2432 
'X-RAY DIFFRACTION' 1.65 1.70  . . 140 3333 99.94  . . . . 0.2153 . . . . . . . . . . . 0.2309 
'X-RAY DIFFRACTION' 1.70 1.76  . . 143 3347 99.97  . . . . 0.2167 . . . . . . . . . . . 0.2511 
'X-RAY DIFFRACTION' 1.76 1.82  . . 136 3366 100.00 . . . . 0.2177 . . . . . . . . . . . 0.2752 
'X-RAY DIFFRACTION' 1.82 1.89  . . 140 3353 99.97  . . . . 0.2074 . . . . . . . . . . . 0.2323 
'X-RAY DIFFRACTION' 1.89 1.98  . . 147 3336 99.89  . . . . 0.2052 . . . . . . . . . . . 0.2078 
'X-RAY DIFFRACTION' 1.98 2.08  . . 140 3380 100.00 . . . . 0.2003 . . . . . . . . . . . 0.2186 
'X-RAY DIFFRACTION' 2.08 2.21  . . 138 3375 100.00 . . . . 0.2030 . . . . . . . . . . . 0.2267 
'X-RAY DIFFRACTION' 2.21 2.38  . . 142 3385 99.97  . . . . 0.2078 . . . . . . . . . . . 0.2283 
'X-RAY DIFFRACTION' 2.38 2.62  . . 143 3370 99.86  . . . . 0.2044 . . . . . . . . . . . 0.2410 
'X-RAY DIFFRACTION' 2.62 3.00  . . 140 3429 99.83  . . . . 0.2141 . . . . . . . . . . . 0.2169 
'X-RAY DIFFRACTION' 3.00 3.78  . . 152 3446 99.97  . . . . 0.1832 . . . . . . . . . . . 0.1925 
'X-RAY DIFFRACTION' 3.78 46.71 . . 150 3607 99.92  . . . . 0.1794 . . . . . . . . . . . 0.2018 
# 
_struct.entry_id                     8VJD 
_struct.title                        'Human R14A Pin1 covalently bound to inhibitor 158F10 in P21 21 21 space group' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8VJD 
_struct_keywords.text            
'Destabilizing Inhbitor, PPIase, Structure-Activity Relationship, Drug Design, ISOMERASE, ISOMERASE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   ISOMERASE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 3 ? 
M N N 4 ? 
N N N 4 ? 
O N N 4 ? 
P N N 5 ? 
Q N N 5 ? 
R N N 5 ? 
S N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PIN1_HUMAN Q13526 ? 1 
;MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITR
TKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIIL
RTE
;
1 
2 PDB 8VJD       8VJD   ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8VJD A 4 ? 166 ? Q13526 1 ? 163 ? 1 163 
2 1 8VJD B 4 ? 166 ? Q13526 1 ? 163 ? 1 163 
3 2 8VJD C 1 ? 5   ? 8VJD   1 ? 5   ? 1 5   
4 2 8VJD D 1 ? 5   ? 8VJD   1 ? 5   ? 1 5   
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8VJD GLY A 1  ? UNP Q13526 ?   ?  'expression tag'      -2 1 
1 8VJD SER A 2  ? UNP Q13526 ?   ?  'expression tag'      -1 2 
1 8VJD HIS A 3  ? UNP Q13526 ?   ?  'expression tag'      0  3 
1 8VJD ALA A 17 ? UNP Q13526 ARG 14 'engineered mutation' 14 4 
2 8VJD GLY B 1  ? UNP Q13526 ?   ?  'expression tag'      -2 5 
2 8VJD SER B 2  ? UNP Q13526 ?   ?  'expression tag'      -1 6 
2 8VJD HIS B 3  ? UNP Q13526 ?   ?  'expression tag'      0  7 
2 8VJD ALA B 17 ? UNP Q13526 ARG 14 'engineered mutation' 14 8 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2760 ? 
1 MORE         -69  ? 
1 'SSA (A^2)'  8250 ? 
2 'ABSA (A^2)' 2300 ? 
2 MORE         -43  ? 
2 'SSA (A^2)'  8030 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,E,F,G,H,I,J,K,P,R 
2 1 B,D,L,M,N,O,Q,S       
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                'Elutes as a monomer off the column' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 84  ? SER A 101 ? THR A 81  SER A 98  1 ? 18 
HELX_P HELX_P2 AA2 ASP A 105 ? SER A 114 ? ASP A 102 SER A 111 1 ? 10 
HELX_P HELX_P3 AA3 GLN A 134 ? LEU A 144 ? GLN A 131 LEU A 141 1 ? 11 
HELX_P HELX_P4 AA4 THR B 84  ? SER B 101 ? THR B 81  SER B 98  1 ? 18 
HELX_P HELX_P5 AA5 ASP B 105 ? SER B 114 ? ASP B 102 SER B 111 1 ? 10 
HELX_P HELX_P6 AA6 CYS B 116 ? ARG B 122 ? CYS B 113 ARG B 119 5 ? 7  
HELX_P HELX_P7 AA7 GLN B 134 ? LEU B 144 ? GLN B 131 LEU B 141 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale none ? A CYS   116 SG ? ? ? 1_555 C ACE   1 CH3 ? ? A CYS   113 C ACE   1 1_555 ? ? ? ? ? ? ? 1.615 ? ? 
covale2  covale none ? B CYS   116 SG ? ? ? 1_555 D ACE   1 CH3 ? ? B CYS   113 D ACE   1 1_555 ? ? ? ? ? ? ? 1.921 ? ? 
covale3  covale both ? C ACE   1   C  ? ? ? 1_555 C PHE   2 N   ? ? C ACE   1   C PHE   2 1_555 ? ? ? ? ? ? ? 1.430 ? ? 
covale4  covale both ? C PHE   2   C  ? ? ? 1_555 C YCP   3 N   ? ? C PHE   2   C YCP   3 1_555 ? ? ? ? ? ? ? 1.430 ? ? 
covale5  covale both ? C YCP   3   C  ? ? ? 1_555 C A1A2Y 4 N   ? ? C YCP   3   C A1A2Y 4 1_555 ? ? ? ? ? ? ? 1.438 ? ? 
covale6  covale both ? C A1A2Y 4   C  ? ? ? 1_555 C NH2   5 N   ? ? C A1A2Y 4   C NH2   5 1_555 ? ? ? ? ? ? ? 1.434 ? ? 
covale7  covale both ? D ACE   1   C  ? ? ? 1_555 D PHE   2 N   ? ? D ACE   1   D PHE   2 1_555 ? ? ? ? ? ? ? 1.428 ? ? 
covale8  covale both ? D PHE   2   C  ? ? ? 1_555 D YCP   3 N   ? ? D PHE   2   D YCP   3 1_555 ? ? ? ? ? ? ? 1.431 ? ? 
covale9  covale both ? D YCP   3   C  ? ? ? 1_555 D A1A2Y 4 N   ? ? D YCP   3   D A1A2Y 4 1_555 ? ? ? ? ? ? ? 1.437 ? ? 
covale10 covale both ? D A1A2Y 4   C  ? ? ? 1_555 D NH2   5 N   ? ? D A1A2Y 4   D NH2   5 1_555 ? ? ? ? ? ? ? 1.453 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  A1A2Y C 4   ? .     . . . A1A2Y C 4   ? 1_555 .     . . . .     .  .   TRP   1  A1A2Y Methoxylation 
'Named protein modification' 
2  A1A2Y D 4   ? .     . . . A1A2Y D 4   ? 1_555 .     . . . .     .  .   TRP   1  A1A2Y Methoxylation 
'Named protein modification' 
3  YCP   C 3   ? .     . . . YCP   C 3   ? 1_555 .     . . . .     .  .   ?     1  YCP   None          'Non-standard residue' 
4  YCP   D 3   ? .     . . . YCP   D 3   ? 1_555 .     . . . .     .  .   ?     1  YCP   None          'Non-standard residue' 
5  ACE   C 1   ? PHE   C 2 ? ACE   C 1   ? 1_555 PHE   C 2 ? 1_555 .  .   PHE   15 ACE   None          'Terminal acetylation' 
6  ACE   D 1   ? PHE   D 2 ? ACE   D 1   ? 1_555 PHE   D 2 ? 1_555 .  .   PHE   15 ACE   None          'Terminal acetylation' 
7  NH2   C 5   ? A1A2Y C 4 ? NH2   C 5   ? 1_555 A1A2Y C 4 ? 1_555 .  .   A1A2Y 42 NH2   None          'Terminal amidation' 
8  NH2   D 5   ? A1A2Y D 4 ? NH2   D 5   ? 1_555 A1A2Y D 4 ? 1_555 .  .   A1A2Y 42 NH2   None          'Terminal amidation' 
9  CYS   A 116 ? ACE   C 1 ? CYS   A 113 ? 1_555 ACE   C 1 ? 1_555 SG CH3 .     .  .     None          'Non-standard linkage' 
10 CYS   B 116 ? ACE   D 1 ? CYS   B 113 ? 1_555 ACE   D 1 ? 1_555 SG CH3 .     .  .     None          'Non-standard linkage' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 4 ? 
AA3 ? 3 ? 
AA4 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TRP A 14  ? MET A 18  ? TRP A 11  MET A 15  
AA1 2 VAL A 25  ? ASN A 29  ? VAL A 22  ASN A 26  
AA1 3 SER A 35  ? GLN A 36  ? SER A 32  GLN A 33  
AA2 1 ASP A 124 ? SER A 129 ? ASP A 121 SER A 126 
AA2 2 ARG A 57  ? VAL A 65  ? ARG A 54  VAL A 62  
AA2 3 GLY A 158 ? GLU A 166 ? GLY A 155 GLU A 163 
AA2 4 VAL A 153 ? THR A 155 ? VAL A 150 THR A 152 
AA3 1 TRP B 14  ? MET B 18  ? TRP B 11  MET B 15  
AA3 2 VAL B 25  ? ASN B 29  ? VAL B 22  ASN B 26  
AA3 3 SER B 35  ? GLN B 36  ? SER B 32  GLN B 33  
AA4 1 ASP B 124 ? PHE B 128 ? ASP B 121 PHE B 125 
AA4 2 VAL B 58  ? VAL B 65  ? VAL B 55  VAL B 62  
AA4 3 GLY B 158 ? ARG B 164 ? GLY B 155 ARG B 161 
AA4 4 VAL B 153 ? THR B 155 ? VAL B 150 THR B 152 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 17  ? N ALA A 14  O TYR A 26  ? O TYR A 23  
AA1 2 3 N TYR A 27  ? N TYR A 24  O GLN A 36  ? O GLN A 33  
AA2 1 2 O LEU A 125 ? O LEU A 122 N CYS A 60  ? N CYS A 57  
AA2 2 3 N VAL A 65  ? N VAL A 62  O ILE A 159 ? O ILE A 156 
AA2 3 4 O HIS A 160 ? O HIS A 157 N VAL A 153 ? N VAL A 150 
AA3 1 2 N GLU B 15  ? N GLU B 12  O PHE B 28  ? O PHE B 25  
AA3 2 3 N TYR B 27  ? N TYR B 24  O GLN B 36  ? O GLN B 33  
AA4 1 2 O LEU B 125 ? O LEU B 122 N CYS B 60  ? N CYS B 57  
AA4 2 3 N VAL B 65  ? N VAL B 62  O ILE B 159 ? O ILE B 156 
AA4 3 4 O HIS B 160 ? O HIS B 157 N VAL B 153 ? N VAL B 150 
# 
_pdbx_entry_details.entry_id                   8VJD 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 YCP C 3 ? ? -111.51 75.16 
2 1 YCP D 3 ? ? -113.23 69.98 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       449 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.84 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -2 ? A GLY 1  
2  1 Y 1 A SER -1 ? A SER 2  
3  1 Y 1 A HIS 0  ? A HIS 3  
4  1 Y 1 A MET 1  ? A MET 4  
5  1 Y 1 A ALA 2  ? A ALA 5  
6  1 Y 1 A ASP 3  ? A ASP 6  
7  1 Y 1 A GLU 4  ? A GLU 7  
8  1 Y 1 A GLU 5  ? A GLU 8  
9  1 Y 1 A LYS 6  ? A LYS 9  
10 1 Y 1 A GLY 39 ? A GLY 42 
11 1 Y 1 A ASN 40 ? A ASN 43 
12 1 Y 1 A SER 41 ? A SER 44 
13 1 Y 1 A SER 42 ? A SER 45 
14 1 Y 1 A SER 43 ? A SER 46 
15 1 Y 1 A GLY 44 ? A GLY 47 
16 1 Y 1 A GLY 45 ? A GLY 48 
17 1 Y 1 A LYS 46 ? A LYS 49 
18 1 Y 1 A ASN 47 ? A ASN 50 
19 1 Y 1 A GLY 48 ? A GLY 51 
20 1 Y 1 A GLN 49 ? A GLN 52 
21 1 Y 1 A GLY 50 ? A GLY 53 
22 1 Y 1 B GLY -2 ? B GLY 1  
23 1 Y 1 B SER -1 ? B SER 2  
24 1 Y 1 B HIS 0  ? B HIS 3  
25 1 Y 1 B MET 1  ? B MET 4  
26 1 Y 1 B ALA 2  ? B ALA 5  
27 1 Y 1 B ASP 3  ? B ASP 6  
28 1 Y 1 B GLU 4  ? B GLU 7  
29 1 Y 1 B GLU 5  ? B GLU 8  
30 1 Y 1 B LYS 6  ? B LYS 9  
31 1 Y 1 B GLY 39 ? B GLY 42 
32 1 Y 1 B ASN 40 ? B ASN 43 
33 1 Y 1 B SER 41 ? B SER 44 
34 1 Y 1 B SER 42 ? B SER 45 
35 1 Y 1 B SER 43 ? B SER 46 
36 1 Y 1 B GLY 44 ? B GLY 47 
37 1 Y 1 B GLY 45 ? B GLY 48 
38 1 Y 1 B LYS 46 ? B LYS 49 
39 1 Y 1 B ASN 47 ? B ASN 50 
40 1 Y 1 B GLY 48 ? B GLY 51 
41 1 Y 1 B GLN 49 ? B GLN 52 
42 1 Y 1 B GLY 50 ? B GLY 53 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1A2Y N    N N N 1   
A1A2Y CA   C N S 2   
A1A2Y C    C N N 3   
A1A2Y CB   C N N 4   
A1A2Y CG   C Y N 5   
A1A2Y CD1  C Y N 6   
A1A2Y CE2  C Y N 7   
A1A2Y CD2  C Y N 8   
A1A2Y CE3  C Y N 9   
A1A2Y CZ3  C Y N 10  
A1A2Y O23  O N N 11  
A1A2Y C24  C N N 12  
A1A2Y CZ2  C Y N 13  
A1A2Y NE1  N Y N 14  
A1A2Y CH2  C Y N 15  
A1A2Y O    O N N 16  
A1A2Y H    H N N 17  
A1A2Y H2   H N N 18  
A1A2Y HA   H N N 19  
A1A2Y HXT  H N N 20  
A1A2Y HB2  H N N 21  
A1A2Y HB3  H N N 22  
A1A2Y HD1  H N N 23  
A1A2Y HE3  H N N 24  
A1A2Y H10  H N N 25  
A1A2Y H11  H N N 26  
A1A2Y H12  H N N 27  
A1A2Y HZ2  H N N 28  
A1A2Y HE1  H N N 29  
A1A2Y HH2  H N N 30  
A1A2Y OXT  O N N 31  
ACE   C    C N N 32  
ACE   O    O N N 33  
ACE   CH3  C N N 34  
ACE   H    H N N 35  
ACE   H1   H N N 36  
ACE   H2   H N N 37  
ACE   H3   H N N 38  
ALA   N    N N N 39  
ALA   CA   C N S 40  
ALA   C    C N N 41  
ALA   O    O N N 42  
ALA   CB   C N N 43  
ALA   OXT  O N N 44  
ALA   H    H N N 45  
ALA   H2   H N N 46  
ALA   HA   H N N 47  
ALA   HB1  H N N 48  
ALA   HB2  H N N 49  
ALA   HB3  H N N 50  
ALA   HXT  H N N 51  
ARG   N    N N N 52  
ARG   CA   C N S 53  
ARG   C    C N N 54  
ARG   O    O N N 55  
ARG   CB   C N N 56  
ARG   CG   C N N 57  
ARG   CD   C N N 58  
ARG   NE   N N N 59  
ARG   CZ   C N N 60  
ARG   NH1  N N N 61  
ARG   NH2  N N N 62  
ARG   OXT  O N N 63  
ARG   H    H N N 64  
ARG   H2   H N N 65  
ARG   HA   H N N 66  
ARG   HB2  H N N 67  
ARG   HB3  H N N 68  
ARG   HG2  H N N 69  
ARG   HG3  H N N 70  
ARG   HD2  H N N 71  
ARG   HD3  H N N 72  
ARG   HE   H N N 73  
ARG   HH11 H N N 74  
ARG   HH12 H N N 75  
ARG   HH21 H N N 76  
ARG   HH22 H N N 77  
ARG   HXT  H N N 78  
ASN   N    N N N 79  
ASN   CA   C N S 80  
ASN   C    C N N 81  
ASN   O    O N N 82  
ASN   CB   C N N 83  
ASN   CG   C N N 84  
ASN   OD1  O N N 85  
ASN   ND2  N N N 86  
ASN   OXT  O N N 87  
ASN   H    H N N 88  
ASN   H2   H N N 89  
ASN   HA   H N N 90  
ASN   HB2  H N N 91  
ASN   HB3  H N N 92  
ASN   HD21 H N N 93  
ASN   HD22 H N N 94  
ASN   HXT  H N N 95  
ASP   N    N N N 96  
ASP   CA   C N S 97  
ASP   C    C N N 98  
ASP   O    O N N 99  
ASP   CB   C N N 100 
ASP   CG   C N N 101 
ASP   OD1  O N N 102 
ASP   OD2  O N N 103 
ASP   OXT  O N N 104 
ASP   H    H N N 105 
ASP   H2   H N N 106 
ASP   HA   H N N 107 
ASP   HB2  H N N 108 
ASP   HB3  H N N 109 
ASP   HD2  H N N 110 
ASP   HXT  H N N 111 
CYS   N    N N N 112 
CYS   CA   C N R 113 
CYS   C    C N N 114 
CYS   O    O N N 115 
CYS   CB   C N N 116 
CYS   SG   S N N 117 
CYS   OXT  O N N 118 
CYS   H    H N N 119 
CYS   H2   H N N 120 
CYS   HA   H N N 121 
CYS   HB2  H N N 122 
CYS   HB3  H N N 123 
CYS   HG   H N N 124 
CYS   HXT  H N N 125 
GLN   N    N N N 126 
GLN   CA   C N S 127 
GLN   C    C N N 128 
GLN   O    O N N 129 
GLN   CB   C N N 130 
GLN   CG   C N N 131 
GLN   CD   C N N 132 
GLN   OE1  O N N 133 
GLN   NE2  N N N 134 
GLN   OXT  O N N 135 
GLN   H    H N N 136 
GLN   H2   H N N 137 
GLN   HA   H N N 138 
GLN   HB2  H N N 139 
GLN   HB3  H N N 140 
GLN   HG2  H N N 141 
GLN   HG3  H N N 142 
GLN   HE21 H N N 143 
GLN   HE22 H N N 144 
GLN   HXT  H N N 145 
GLU   N    N N N 146 
GLU   CA   C N S 147 
GLU   C    C N N 148 
GLU   O    O N N 149 
GLU   CB   C N N 150 
GLU   CG   C N N 151 
GLU   CD   C N N 152 
GLU   OE1  O N N 153 
GLU   OE2  O N N 154 
GLU   OXT  O N N 155 
GLU   H    H N N 156 
GLU   H2   H N N 157 
GLU   HA   H N N 158 
GLU   HB2  H N N 159 
GLU   HB3  H N N 160 
GLU   HG2  H N N 161 
GLU   HG3  H N N 162 
GLU   HE2  H N N 163 
GLU   HXT  H N N 164 
GLY   N    N N N 165 
GLY   CA   C N N 166 
GLY   C    C N N 167 
GLY   O    O N N 168 
GLY   OXT  O N N 169 
GLY   H    H N N 170 
GLY   H2   H N N 171 
GLY   HA2  H N N 172 
GLY   HA3  H N N 173 
GLY   HXT  H N N 174 
HIS   N    N N N 175 
HIS   CA   C N S 176 
HIS   C    C N N 177 
HIS   O    O N N 178 
HIS   CB   C N N 179 
HIS   CG   C Y N 180 
HIS   ND1  N Y N 181 
HIS   CD2  C Y N 182 
HIS   CE1  C Y N 183 
HIS   NE2  N Y N 184 
HIS   OXT  O N N 185 
HIS   H    H N N 186 
HIS   H2   H N N 187 
HIS   HA   H N N 188 
HIS   HB2  H N N 189 
HIS   HB3  H N N 190 
HIS   HD1  H N N 191 
HIS   HD2  H N N 192 
HIS   HE1  H N N 193 
HIS   HE2  H N N 194 
HIS   HXT  H N N 195 
HOH   O    O N N 196 
HOH   H1   H N N 197 
HOH   H2   H N N 198 
ILE   N    N N N 199 
ILE   CA   C N S 200 
ILE   C    C N N 201 
ILE   O    O N N 202 
ILE   CB   C N S 203 
ILE   CG1  C N N 204 
ILE   CG2  C N N 205 
ILE   CD1  C N N 206 
ILE   OXT  O N N 207 
ILE   H    H N N 208 
ILE   H2   H N N 209 
ILE   HA   H N N 210 
ILE   HB   H N N 211 
ILE   HG12 H N N 212 
ILE   HG13 H N N 213 
ILE   HG21 H N N 214 
ILE   HG22 H N N 215 
ILE   HG23 H N N 216 
ILE   HD11 H N N 217 
ILE   HD12 H N N 218 
ILE   HD13 H N N 219 
ILE   HXT  H N N 220 
LEU   N    N N N 221 
LEU   CA   C N S 222 
LEU   C    C N N 223 
LEU   O    O N N 224 
LEU   CB   C N N 225 
LEU   CG   C N N 226 
LEU   CD1  C N N 227 
LEU   CD2  C N N 228 
LEU   OXT  O N N 229 
LEU   H    H N N 230 
LEU   H2   H N N 231 
LEU   HA   H N N 232 
LEU   HB2  H N N 233 
LEU   HB3  H N N 234 
LEU   HG   H N N 235 
LEU   HD11 H N N 236 
LEU   HD12 H N N 237 
LEU   HD13 H N N 238 
LEU   HD21 H N N 239 
LEU   HD22 H N N 240 
LEU   HD23 H N N 241 
LEU   HXT  H N N 242 
LYS   N    N N N 243 
LYS   CA   C N S 244 
LYS   C    C N N 245 
LYS   O    O N N 246 
LYS   CB   C N N 247 
LYS   CG   C N N 248 
LYS   CD   C N N 249 
LYS   CE   C N N 250 
LYS   NZ   N N N 251 
LYS   OXT  O N N 252 
LYS   H    H N N 253 
LYS   H2   H N N 254 
LYS   HA   H N N 255 
LYS   HB2  H N N 256 
LYS   HB3  H N N 257 
LYS   HG2  H N N 258 
LYS   HG3  H N N 259 
LYS   HD2  H N N 260 
LYS   HD3  H N N 261 
LYS   HE2  H N N 262 
LYS   HE3  H N N 263 
LYS   HZ1  H N N 264 
LYS   HZ2  H N N 265 
LYS   HZ3  H N N 266 
LYS   HXT  H N N 267 
MET   N    N N N 268 
MET   CA   C N S 269 
MET   C    C N N 270 
MET   O    O N N 271 
MET   CB   C N N 272 
MET   CG   C N N 273 
MET   SD   S N N 274 
MET   CE   C N N 275 
MET   OXT  O N N 276 
MET   H    H N N 277 
MET   H2   H N N 278 
MET   HA   H N N 279 
MET   HB2  H N N 280 
MET   HB3  H N N 281 
MET   HG2  H N N 282 
MET   HG3  H N N 283 
MET   HE1  H N N 284 
MET   HE2  H N N 285 
MET   HE3  H N N 286 
MET   HXT  H N N 287 
NH2   N    N N N 288 
NH2   HN1  H N N 289 
NH2   HN2  H N N 290 
P33   O22  O N N 291 
P33   C21  C N N 292 
P33   C20  C N N 293 
P33   O19  O N N 294 
P33   C18  C N N 295 
P33   C17  C N N 296 
P33   O16  O N N 297 
P33   C15  C N N 298 
P33   C14  C N N 299 
P33   O13  O N N 300 
P33   C12  C N N 301 
P33   C11  C N N 302 
P33   O10  O N N 303 
P33   C9   C N N 304 
P33   C8   C N N 305 
P33   O7   O N N 306 
P33   C6   C N N 307 
P33   C5   C N N 308 
P33   O4   O N N 309 
P33   C3   C N N 310 
P33   C2   C N N 311 
P33   O1   O N N 312 
P33   H22  H N N 313 
P33   H211 H N N 314 
P33   H212 H N N 315 
P33   H201 H N N 316 
P33   H202 H N N 317 
P33   H181 H N N 318 
P33   H182 H N N 319 
P33   H171 H N N 320 
P33   H172 H N N 321 
P33   H151 H N N 322 
P33   H152 H N N 323 
P33   H141 H N N 324 
P33   H142 H N N 325 
P33   H121 H N N 326 
P33   H122 H N N 327 
P33   H111 H N N 328 
P33   H112 H N N 329 
P33   H91  H N N 330 
P33   H92  H N N 331 
P33   H81  H N N 332 
P33   H82  H N N 333 
P33   H61  H N N 334 
P33   H62  H N N 335 
P33   H51  H N N 336 
P33   H52  H N N 337 
P33   H31  H N N 338 
P33   H32  H N N 339 
P33   H21  H N N 340 
P33   H22A H N N 341 
P33   HO1  H N N 342 
PHE   N    N N N 343 
PHE   CA   C N S 344 
PHE   C    C N N 345 
PHE   O    O N N 346 
PHE   CB   C N N 347 
PHE   CG   C Y N 348 
PHE   CD1  C Y N 349 
PHE   CD2  C Y N 350 
PHE   CE1  C Y N 351 
PHE   CE2  C Y N 352 
PHE   CZ   C Y N 353 
PHE   OXT  O N N 354 
PHE   H    H N N 355 
PHE   H2   H N N 356 
PHE   HA   H N N 357 
PHE   HB2  H N N 358 
PHE   HB3  H N N 359 
PHE   HD1  H N N 360 
PHE   HD2  H N N 361 
PHE   HE1  H N N 362 
PHE   HE2  H N N 363 
PHE   HZ   H N N 364 
PHE   HXT  H N N 365 
PRO   N    N N N 366 
PRO   CA   C N S 367 
PRO   C    C N N 368 
PRO   O    O N N 369 
PRO   CB   C N N 370 
PRO   CG   C N N 371 
PRO   CD   C N N 372 
PRO   OXT  O N N 373 
PRO   H    H N N 374 
PRO   HA   H N N 375 
PRO   HB2  H N N 376 
PRO   HB3  H N N 377 
PRO   HG2  H N N 378 
PRO   HG3  H N N 379 
PRO   HD2  H N N 380 
PRO   HD3  H N N 381 
PRO   HXT  H N N 382 
SER   N    N N N 383 
SER   CA   C N S 384 
SER   C    C N N 385 
SER   O    O N N 386 
SER   CB   C N N 387 
SER   OG   O N N 388 
SER   OXT  O N N 389 
SER   H    H N N 390 
SER   H2   H N N 391 
SER   HA   H N N 392 
SER   HB2  H N N 393 
SER   HB3  H N N 394 
SER   HG   H N N 395 
SER   HXT  H N N 396 
SO4   S    S N N 397 
SO4   O1   O N N 398 
SO4   O2   O N N 399 
SO4   O3   O N N 400 
SO4   O4   O N N 401 
THR   N    N N N 402 
THR   CA   C N S 403 
THR   C    C N N 404 
THR   O    O N N 405 
THR   CB   C N R 406 
THR   OG1  O N N 407 
THR   CG2  C N N 408 
THR   OXT  O N N 409 
THR   H    H N N 410 
THR   H2   H N N 411 
THR   HA   H N N 412 
THR   HB   H N N 413 
THR   HG1  H N N 414 
THR   HG21 H N N 415 
THR   HG22 H N N 416 
THR   HG23 H N N 417 
THR   HXT  H N N 418 
TRP   N    N N N 419 
TRP   CA   C N S 420 
TRP   C    C N N 421 
TRP   O    O N N 422 
TRP   CB   C N N 423 
TRP   CG   C Y N 424 
TRP   CD1  C Y N 425 
TRP   CD2  C Y N 426 
TRP   NE1  N Y N 427 
TRP   CE2  C Y N 428 
TRP   CE3  C Y N 429 
TRP   CZ2  C Y N 430 
TRP   CZ3  C Y N 431 
TRP   CH2  C Y N 432 
TRP   OXT  O N N 433 
TRP   H    H N N 434 
TRP   H2   H N N 435 
TRP   HA   H N N 436 
TRP   HB2  H N N 437 
TRP   HB3  H N N 438 
TRP   HD1  H N N 439 
TRP   HE1  H N N 440 
TRP   HE3  H N N 441 
TRP   HZ2  H N N 442 
TRP   HZ3  H N N 443 
TRP   HH2  H N N 444 
TRP   HXT  H N N 445 
TYR   N    N N N 446 
TYR   CA   C N S 447 
TYR   C    C N N 448 
TYR   O    O N N 449 
TYR   CB   C N N 450 
TYR   CG   C Y N 451 
TYR   CD1  C Y N 452 
TYR   CD2  C Y N 453 
TYR   CE1  C Y N 454 
TYR   CE2  C Y N 455 
TYR   CZ   C Y N 456 
TYR   OH   O N N 457 
TYR   OXT  O N N 458 
TYR   H    H N N 459 
TYR   H2   H N N 460 
TYR   HA   H N N 461 
TYR   HB2  H N N 462 
TYR   HB3  H N N 463 
TYR   HD1  H N N 464 
TYR   HD2  H N N 465 
TYR   HE1  H N N 466 
TYR   HE2  H N N 467 
TYR   HH   H N N 468 
TYR   HXT  H N N 469 
VAL   N    N N N 470 
VAL   CA   C N S 471 
VAL   C    C N N 472 
VAL   O    O N N 473 
VAL   CB   C N N 474 
VAL   CG1  C N N 475 
VAL   CG2  C N N 476 
VAL   OXT  O N N 477 
VAL   H    H N N 478 
VAL   H2   H N N 479 
VAL   HA   H N N 480 
VAL   HB   H N N 481 
VAL   HG11 H N N 482 
VAL   HG12 H N N 483 
VAL   HG13 H N N 484 
VAL   HG21 H N N 485 
VAL   HG22 H N N 486 
VAL   HG23 H N N 487 
VAL   HXT  H N N 488 
YCP   C    C N N 489 
YCP   N    N N N 490 
YCP   O    O N N 491 
YCP   CA   C N S 492 
YCP   CB   C N N 493 
YCP   CD   C N N 494 
YCP   CE   C N N 495 
YCP   CG   C N N 496 
YCP   OXT  O N N 497 
YCP   H    H N N 498 
YCP   HA   H N N 499 
YCP   HB   H N N 500 
YCP   HBA  H N N 501 
YCP   HD   H N N 502 
YCP   HDA  H N N 503 
YCP   HE   H N N 504 
YCP   HEA  H N N 505 
YCP   HG   H N N 506 
YCP   HGA  H N N 507 
YCP   HXT  H N N 508 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1A2Y O   C    doub N N 1   
A1A2Y C   CA   sing N N 2   
A1A2Y N   CA   sing N N 3   
A1A2Y CA  CB   sing N N 4   
A1A2Y CB  CG   sing N N 5   
A1A2Y CG  CD1  doub Y N 6   
A1A2Y CG  CD2  sing Y N 7   
A1A2Y CD1 NE1  sing Y N 8   
A1A2Y CE3 CD2  doub Y N 9   
A1A2Y CE3 CZ3  sing Y N 10  
A1A2Y CD2 CE2  sing Y N 11  
A1A2Y NE1 CE2  sing Y N 12  
A1A2Y O23 CZ3  sing N N 13  
A1A2Y O23 C24  sing N N 14  
A1A2Y CZ3 CH2  doub Y N 15  
A1A2Y CE2 CZ2  doub Y N 16  
A1A2Y CH2 CZ2  sing Y N 17  
A1A2Y N   H    sing N N 18  
A1A2Y N   H2   sing N N 19  
A1A2Y CA  HA   sing N N 20  
A1A2Y CB  HB2  sing N N 21  
A1A2Y CB  HB3  sing N N 22  
A1A2Y CD1 HD1  sing N N 23  
A1A2Y CE3 HE3  sing N N 24  
A1A2Y C24 H10  sing N N 25  
A1A2Y C24 H11  sing N N 26  
A1A2Y C24 H12  sing N N 27  
A1A2Y CZ2 HZ2  sing N N 28  
A1A2Y NE1 HE1  sing N N 29  
A1A2Y CH2 HH2  sing N N 30  
A1A2Y C   OXT  sing N N 31  
A1A2Y OXT HXT  sing N N 32  
ACE   C   O    doub N N 33  
ACE   C   CH3  sing N N 34  
ACE   C   H    sing N N 35  
ACE   CH3 H1   sing N N 36  
ACE   CH3 H2   sing N N 37  
ACE   CH3 H3   sing N N 38  
ALA   N   CA   sing N N 39  
ALA   N   H    sing N N 40  
ALA   N   H2   sing N N 41  
ALA   CA  C    sing N N 42  
ALA   CA  CB   sing N N 43  
ALA   CA  HA   sing N N 44  
ALA   C   O    doub N N 45  
ALA   C   OXT  sing N N 46  
ALA   CB  HB1  sing N N 47  
ALA   CB  HB2  sing N N 48  
ALA   CB  HB3  sing N N 49  
ALA   OXT HXT  sing N N 50  
ARG   N   CA   sing N N 51  
ARG   N   H    sing N N 52  
ARG   N   H2   sing N N 53  
ARG   CA  C    sing N N 54  
ARG   CA  CB   sing N N 55  
ARG   CA  HA   sing N N 56  
ARG   C   O    doub N N 57  
ARG   C   OXT  sing N N 58  
ARG   CB  CG   sing N N 59  
ARG   CB  HB2  sing N N 60  
ARG   CB  HB3  sing N N 61  
ARG   CG  CD   sing N N 62  
ARG   CG  HG2  sing N N 63  
ARG   CG  HG3  sing N N 64  
ARG   CD  NE   sing N N 65  
ARG   CD  HD2  sing N N 66  
ARG   CD  HD3  sing N N 67  
ARG   NE  CZ   sing N N 68  
ARG   NE  HE   sing N N 69  
ARG   CZ  NH1  sing N N 70  
ARG   CZ  NH2  doub N N 71  
ARG   NH1 HH11 sing N N 72  
ARG   NH1 HH12 sing N N 73  
ARG   NH2 HH21 sing N N 74  
ARG   NH2 HH22 sing N N 75  
ARG   OXT HXT  sing N N 76  
ASN   N   CA   sing N N 77  
ASN   N   H    sing N N 78  
ASN   N   H2   sing N N 79  
ASN   CA  C    sing N N 80  
ASN   CA  CB   sing N N 81  
ASN   CA  HA   sing N N 82  
ASN   C   O    doub N N 83  
ASN   C   OXT  sing N N 84  
ASN   CB  CG   sing N N 85  
ASN   CB  HB2  sing N N 86  
ASN   CB  HB3  sing N N 87  
ASN   CG  OD1  doub N N 88  
ASN   CG  ND2  sing N N 89  
ASN   ND2 HD21 sing N N 90  
ASN   ND2 HD22 sing N N 91  
ASN   OXT HXT  sing N N 92  
ASP   N   CA   sing N N 93  
ASP   N   H    sing N N 94  
ASP   N   H2   sing N N 95  
ASP   CA  C    sing N N 96  
ASP   CA  CB   sing N N 97  
ASP   CA  HA   sing N N 98  
ASP   C   O    doub N N 99  
ASP   C   OXT  sing N N 100 
ASP   CB  CG   sing N N 101 
ASP   CB  HB2  sing N N 102 
ASP   CB  HB3  sing N N 103 
ASP   CG  OD1  doub N N 104 
ASP   CG  OD2  sing N N 105 
ASP   OD2 HD2  sing N N 106 
ASP   OXT HXT  sing N N 107 
CYS   N   CA   sing N N 108 
CYS   N   H    sing N N 109 
CYS   N   H2   sing N N 110 
CYS   CA  C    sing N N 111 
CYS   CA  CB   sing N N 112 
CYS   CA  HA   sing N N 113 
CYS   C   O    doub N N 114 
CYS   C   OXT  sing N N 115 
CYS   CB  SG   sing N N 116 
CYS   CB  HB2  sing N N 117 
CYS   CB  HB3  sing N N 118 
CYS   SG  HG   sing N N 119 
CYS   OXT HXT  sing N N 120 
GLN   N   CA   sing N N 121 
GLN   N   H    sing N N 122 
GLN   N   H2   sing N N 123 
GLN   CA  C    sing N N 124 
GLN   CA  CB   sing N N 125 
GLN   CA  HA   sing N N 126 
GLN   C   O    doub N N 127 
GLN   C   OXT  sing N N 128 
GLN   CB  CG   sing N N 129 
GLN   CB  HB2  sing N N 130 
GLN   CB  HB3  sing N N 131 
GLN   CG  CD   sing N N 132 
GLN   CG  HG2  sing N N 133 
GLN   CG  HG3  sing N N 134 
GLN   CD  OE1  doub N N 135 
GLN   CD  NE2  sing N N 136 
GLN   NE2 HE21 sing N N 137 
GLN   NE2 HE22 sing N N 138 
GLN   OXT HXT  sing N N 139 
GLU   N   CA   sing N N 140 
GLU   N   H    sing N N 141 
GLU   N   H2   sing N N 142 
GLU   CA  C    sing N N 143 
GLU   CA  CB   sing N N 144 
GLU   CA  HA   sing N N 145 
GLU   C   O    doub N N 146 
GLU   C   OXT  sing N N 147 
GLU   CB  CG   sing N N 148 
GLU   CB  HB2  sing N N 149 
GLU   CB  HB3  sing N N 150 
GLU   CG  CD   sing N N 151 
GLU   CG  HG2  sing N N 152 
GLU   CG  HG3  sing N N 153 
GLU   CD  OE1  doub N N 154 
GLU   CD  OE2  sing N N 155 
GLU   OE2 HE2  sing N N 156 
GLU   OXT HXT  sing N N 157 
GLY   N   CA   sing N N 158 
GLY   N   H    sing N N 159 
GLY   N   H2   sing N N 160 
GLY   CA  C    sing N N 161 
GLY   CA  HA2  sing N N 162 
GLY   CA  HA3  sing N N 163 
GLY   C   O    doub N N 164 
GLY   C   OXT  sing N N 165 
GLY   OXT HXT  sing N N 166 
HIS   N   CA   sing N N 167 
HIS   N   H    sing N N 168 
HIS   N   H2   sing N N 169 
HIS   CA  C    sing N N 170 
HIS   CA  CB   sing N N 171 
HIS   CA  HA   sing N N 172 
HIS   C   O    doub N N 173 
HIS   C   OXT  sing N N 174 
HIS   CB  CG   sing N N 175 
HIS   CB  HB2  sing N N 176 
HIS   CB  HB3  sing N N 177 
HIS   CG  ND1  sing Y N 178 
HIS   CG  CD2  doub Y N 179 
HIS   ND1 CE1  doub Y N 180 
HIS   ND1 HD1  sing N N 181 
HIS   CD2 NE2  sing Y N 182 
HIS   CD2 HD2  sing N N 183 
HIS   CE1 NE2  sing Y N 184 
HIS   CE1 HE1  sing N N 185 
HIS   NE2 HE2  sing N N 186 
HIS   OXT HXT  sing N N 187 
HOH   O   H1   sing N N 188 
HOH   O   H2   sing N N 189 
ILE   N   CA   sing N N 190 
ILE   N   H    sing N N 191 
ILE   N   H2   sing N N 192 
ILE   CA  C    sing N N 193 
ILE   CA  CB   sing N N 194 
ILE   CA  HA   sing N N 195 
ILE   C   O    doub N N 196 
ILE   C   OXT  sing N N 197 
ILE   CB  CG1  sing N N 198 
ILE   CB  CG2  sing N N 199 
ILE   CB  HB   sing N N 200 
ILE   CG1 CD1  sing N N 201 
ILE   CG1 HG12 sing N N 202 
ILE   CG1 HG13 sing N N 203 
ILE   CG2 HG21 sing N N 204 
ILE   CG2 HG22 sing N N 205 
ILE   CG2 HG23 sing N N 206 
ILE   CD1 HD11 sing N N 207 
ILE   CD1 HD12 sing N N 208 
ILE   CD1 HD13 sing N N 209 
ILE   OXT HXT  sing N N 210 
LEU   N   CA   sing N N 211 
LEU   N   H    sing N N 212 
LEU   N   H2   sing N N 213 
LEU   CA  C    sing N N 214 
LEU   CA  CB   sing N N 215 
LEU   CA  HA   sing N N 216 
LEU   C   O    doub N N 217 
LEU   C   OXT  sing N N 218 
LEU   CB  CG   sing N N 219 
LEU   CB  HB2  sing N N 220 
LEU   CB  HB3  sing N N 221 
LEU   CG  CD1  sing N N 222 
LEU   CG  CD2  sing N N 223 
LEU   CG  HG   sing N N 224 
LEU   CD1 HD11 sing N N 225 
LEU   CD1 HD12 sing N N 226 
LEU   CD1 HD13 sing N N 227 
LEU   CD2 HD21 sing N N 228 
LEU   CD2 HD22 sing N N 229 
LEU   CD2 HD23 sing N N 230 
LEU   OXT HXT  sing N N 231 
LYS   N   CA   sing N N 232 
LYS   N   H    sing N N 233 
LYS   N   H2   sing N N 234 
LYS   CA  C    sing N N 235 
LYS   CA  CB   sing N N 236 
LYS   CA  HA   sing N N 237 
LYS   C   O    doub N N 238 
LYS   C   OXT  sing N N 239 
LYS   CB  CG   sing N N 240 
LYS   CB  HB2  sing N N 241 
LYS   CB  HB3  sing N N 242 
LYS   CG  CD   sing N N 243 
LYS   CG  HG2  sing N N 244 
LYS   CG  HG3  sing N N 245 
LYS   CD  CE   sing N N 246 
LYS   CD  HD2  sing N N 247 
LYS   CD  HD3  sing N N 248 
LYS   CE  NZ   sing N N 249 
LYS   CE  HE2  sing N N 250 
LYS   CE  HE3  sing N N 251 
LYS   NZ  HZ1  sing N N 252 
LYS   NZ  HZ2  sing N N 253 
LYS   NZ  HZ3  sing N N 254 
LYS   OXT HXT  sing N N 255 
MET   N   CA   sing N N 256 
MET   N   H    sing N N 257 
MET   N   H2   sing N N 258 
MET   CA  C    sing N N 259 
MET   CA  CB   sing N N 260 
MET   CA  HA   sing N N 261 
MET   C   O    doub N N 262 
MET   C   OXT  sing N N 263 
MET   CB  CG   sing N N 264 
MET   CB  HB2  sing N N 265 
MET   CB  HB3  sing N N 266 
MET   CG  SD   sing N N 267 
MET   CG  HG2  sing N N 268 
MET   CG  HG3  sing N N 269 
MET   SD  CE   sing N N 270 
MET   CE  HE1  sing N N 271 
MET   CE  HE2  sing N N 272 
MET   CE  HE3  sing N N 273 
MET   OXT HXT  sing N N 274 
NH2   N   HN1  sing N N 275 
NH2   N   HN2  sing N N 276 
P33   O22 C21  sing N N 277 
P33   O22 H22  sing N N 278 
P33   C21 C20  sing N N 279 
P33   C21 H211 sing N N 280 
P33   C21 H212 sing N N 281 
P33   C20 O19  sing N N 282 
P33   C20 H201 sing N N 283 
P33   C20 H202 sing N N 284 
P33   O19 C18  sing N N 285 
P33   C18 C17  sing N N 286 
P33   C18 H181 sing N N 287 
P33   C18 H182 sing N N 288 
P33   C17 O16  sing N N 289 
P33   C17 H171 sing N N 290 
P33   C17 H172 sing N N 291 
P33   O16 C15  sing N N 292 
P33   C15 C14  sing N N 293 
P33   C15 H151 sing N N 294 
P33   C15 H152 sing N N 295 
P33   C14 O13  sing N N 296 
P33   C14 H141 sing N N 297 
P33   C14 H142 sing N N 298 
P33   O13 C12  sing N N 299 
P33   C12 C11  sing N N 300 
P33   C12 H121 sing N N 301 
P33   C12 H122 sing N N 302 
P33   C11 O10  sing N N 303 
P33   C11 H111 sing N N 304 
P33   C11 H112 sing N N 305 
P33   O10 C9   sing N N 306 
P33   C9  C8   sing N N 307 
P33   C9  H91  sing N N 308 
P33   C9  H92  sing N N 309 
P33   C8  O7   sing N N 310 
P33   C8  H81  sing N N 311 
P33   C8  H82  sing N N 312 
P33   O7  C6   sing N N 313 
P33   C6  C5   sing N N 314 
P33   C6  H61  sing N N 315 
P33   C6  H62  sing N N 316 
P33   C5  O4   sing N N 317 
P33   C5  H51  sing N N 318 
P33   C5  H52  sing N N 319 
P33   O4  C3   sing N N 320 
P33   C3  C2   sing N N 321 
P33   C3  H31  sing N N 322 
P33   C3  H32  sing N N 323 
P33   C2  O1   sing N N 324 
P33   C2  H21  sing N N 325 
P33   C2  H22A sing N N 326 
P33   O1  HO1  sing N N 327 
PHE   N   CA   sing N N 328 
PHE   N   H    sing N N 329 
PHE   N   H2   sing N N 330 
PHE   CA  C    sing N N 331 
PHE   CA  CB   sing N N 332 
PHE   CA  HA   sing N N 333 
PHE   C   O    doub N N 334 
PHE   C   OXT  sing N N 335 
PHE   CB  CG   sing N N 336 
PHE   CB  HB2  sing N N 337 
PHE   CB  HB3  sing N N 338 
PHE   CG  CD1  doub Y N 339 
PHE   CG  CD2  sing Y N 340 
PHE   CD1 CE1  sing Y N 341 
PHE   CD1 HD1  sing N N 342 
PHE   CD2 CE2  doub Y N 343 
PHE   CD2 HD2  sing N N 344 
PHE   CE1 CZ   doub Y N 345 
PHE   CE1 HE1  sing N N 346 
PHE   CE2 CZ   sing Y N 347 
PHE   CE2 HE2  sing N N 348 
PHE   CZ  HZ   sing N N 349 
PHE   OXT HXT  sing N N 350 
PRO   N   CA   sing N N 351 
PRO   N   CD   sing N N 352 
PRO   N   H    sing N N 353 
PRO   CA  C    sing N N 354 
PRO   CA  CB   sing N N 355 
PRO   CA  HA   sing N N 356 
PRO   C   O    doub N N 357 
PRO   C   OXT  sing N N 358 
PRO   CB  CG   sing N N 359 
PRO   CB  HB2  sing N N 360 
PRO   CB  HB3  sing N N 361 
PRO   CG  CD   sing N N 362 
PRO   CG  HG2  sing N N 363 
PRO   CG  HG3  sing N N 364 
PRO   CD  HD2  sing N N 365 
PRO   CD  HD3  sing N N 366 
PRO   OXT HXT  sing N N 367 
SER   N   CA   sing N N 368 
SER   N   H    sing N N 369 
SER   N   H2   sing N N 370 
SER   CA  C    sing N N 371 
SER   CA  CB   sing N N 372 
SER   CA  HA   sing N N 373 
SER   C   O    doub N N 374 
SER   C   OXT  sing N N 375 
SER   CB  OG   sing N N 376 
SER   CB  HB2  sing N N 377 
SER   CB  HB3  sing N N 378 
SER   OG  HG   sing N N 379 
SER   OXT HXT  sing N N 380 
SO4   S   O1   doub N N 381 
SO4   S   O2   doub N N 382 
SO4   S   O3   sing N N 383 
SO4   S   O4   sing N N 384 
THR   N   CA   sing N N 385 
THR   N   H    sing N N 386 
THR   N   H2   sing N N 387 
THR   CA  C    sing N N 388 
THR   CA  CB   sing N N 389 
THR   CA  HA   sing N N 390 
THR   C   O    doub N N 391 
THR   C   OXT  sing N N 392 
THR   CB  OG1  sing N N 393 
THR   CB  CG2  sing N N 394 
THR   CB  HB   sing N N 395 
THR   OG1 HG1  sing N N 396 
THR   CG2 HG21 sing N N 397 
THR   CG2 HG22 sing N N 398 
THR   CG2 HG23 sing N N 399 
THR   OXT HXT  sing N N 400 
TRP   N   CA   sing N N 401 
TRP   N   H    sing N N 402 
TRP   N   H2   sing N N 403 
TRP   CA  C    sing N N 404 
TRP   CA  CB   sing N N 405 
TRP   CA  HA   sing N N 406 
TRP   C   O    doub N N 407 
TRP   C   OXT  sing N N 408 
TRP   CB  CG   sing N N 409 
TRP   CB  HB2  sing N N 410 
TRP   CB  HB3  sing N N 411 
TRP   CG  CD1  doub Y N 412 
TRP   CG  CD2  sing Y N 413 
TRP   CD1 NE1  sing Y N 414 
TRP   CD1 HD1  sing N N 415 
TRP   CD2 CE2  doub Y N 416 
TRP   CD2 CE3  sing Y N 417 
TRP   NE1 CE2  sing Y N 418 
TRP   NE1 HE1  sing N N 419 
TRP   CE2 CZ2  sing Y N 420 
TRP   CE3 CZ3  doub Y N 421 
TRP   CE3 HE3  sing N N 422 
TRP   CZ2 CH2  doub Y N 423 
TRP   CZ2 HZ2  sing N N 424 
TRP   CZ3 CH2  sing Y N 425 
TRP   CZ3 HZ3  sing N N 426 
TRP   CH2 HH2  sing N N 427 
TRP   OXT HXT  sing N N 428 
TYR   N   CA   sing N N 429 
TYR   N   H    sing N N 430 
TYR   N   H2   sing N N 431 
TYR   CA  C    sing N N 432 
TYR   CA  CB   sing N N 433 
TYR   CA  HA   sing N N 434 
TYR   C   O    doub N N 435 
TYR   C   OXT  sing N N 436 
TYR   CB  CG   sing N N 437 
TYR   CB  HB2  sing N N 438 
TYR   CB  HB3  sing N N 439 
TYR   CG  CD1  doub Y N 440 
TYR   CG  CD2  sing Y N 441 
TYR   CD1 CE1  sing Y N 442 
TYR   CD1 HD1  sing N N 443 
TYR   CD2 CE2  doub Y N 444 
TYR   CD2 HD2  sing N N 445 
TYR   CE1 CZ   doub Y N 446 
TYR   CE1 HE1  sing N N 447 
TYR   CE2 CZ   sing Y N 448 
TYR   CE2 HE2  sing N N 449 
TYR   CZ  OH   sing N N 450 
TYR   OH  HH   sing N N 451 
TYR   OXT HXT  sing N N 452 
VAL   N   CA   sing N N 453 
VAL   N   H    sing N N 454 
VAL   N   H2   sing N N 455 
VAL   CA  C    sing N N 456 
VAL   CA  CB   sing N N 457 
VAL   CA  HA   sing N N 458 
VAL   C   O    doub N N 459 
VAL   C   OXT  sing N N 460 
VAL   CB  CG1  sing N N 461 
VAL   CB  CG2  sing N N 462 
VAL   CB  HB   sing N N 463 
VAL   CG1 HG11 sing N N 464 
VAL   CG1 HG12 sing N N 465 
VAL   CG1 HG13 sing N N 466 
VAL   CG2 HG21 sing N N 467 
VAL   CG2 HG22 sing N N 468 
VAL   CG2 HG23 sing N N 469 
VAL   OXT HXT  sing N N 470 
YCP   C   O    doub N N 471 
YCP   C   CA   sing N N 472 
YCP   C   OXT  sing N N 473 
YCP   N   CA   sing N N 474 
YCP   N   CE   sing N N 475 
YCP   CA  CB   sing N N 476 
YCP   CB  CG   sing N N 477 
YCP   CD  CE   sing N N 478 
YCP   CD  CG   sing N N 479 
YCP   N   H    sing N N 480 
YCP   CA  HA   sing N N 481 
YCP   CB  HB   sing N N 482 
YCP   CB  HBA  sing N N 483 
YCP   CD  HD   sing N N 484 
YCP   CD  HDA  sing N N 485 
YCP   CE  HE   sing N N 486 
YCP   CE  HEA  sing N N 487 
YCP   CG  HG   sing N N 488 
YCP   CG  HGA  sing N N 489 
YCP   OXT HXT  sing N N 490 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS)' 'United States' NS107479 1 
'National Institutes of Health/National Cancer Institute (NIH/NCI)'                                 'United States' CA168517 2 
'National Institutes of Health/National Cancer Institute (NIH/NCI)'                                 'United States' CA285114 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   1 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2Q5A 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8VJD 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016667 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016121 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010705 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LEU   A 1 10  ? 1.04814   -4.19144  -0.78262  1.000 39.06125 ? 7   LEU   A N   1 
ATOM   2    C CA  . LEU   A 1 10  ? 1.01247   -3.59763  0.55057   1.000 34.59155 ? 7   LEU   A CA  1 
ATOM   3    C C   . LEU   A 1 10  ? 1.04865   -2.06888  0.47194   1.000 35.69180 ? 7   LEU   A C   1 
ATOM   4    O O   . LEU   A 1 10  ? 1.63378   -1.51067  -0.45356  1.000 36.40258 ? 7   LEU   A O   1 
ATOM   5    C CB  . LEU   A 1 10  ? 2.17955   -4.11804  1.39585   1.000 28.80173 ? 7   LEU   A CB  1 
ATOM   6    C CG  . LEU   A 1 10  ? 2.20830   -5.61865  1.69662   1.000 30.20423 ? 7   LEU   A CG  1 
ATOM   7    C CD1 . LEU   A 1 10  ? 3.47542   -5.98479  2.44991   1.000 28.23429 ? 7   LEU   A CD1 1 
ATOM   8    C CD2 . LEU   A 1 10  ? 0.97895   -6.04449  2.47869   1.000 31.09335 ? 7   LEU   A CD2 1 
ATOM   9    N N   . PRO   A 1 11  ? 0.41899   -1.39939  1.43582   1.000 34.69115 ? 8   PRO   A N   1 
ATOM   10   C CA  . PRO   A 1 11  ? 0.39212   0.07346   1.44061   1.000 29.92610 ? 8   PRO   A CA  1 
ATOM   11   C C   . PRO   A 1 11  ? 1.78580   0.64671   1.64510   1.000 29.39179 ? 8   PRO   A C   1 
ATOM   12   O O   . PRO   A 1 11  ? 2.72296   -0.09277  1.98096   1.000 26.75943 ? 8   PRO   A O   1 
ATOM   13   C CB  . PRO   A 1 11  ? -0.53782  0.40152   2.62275   1.000 32.04469 ? 8   PRO   A CB  1 
ATOM   14   C CG  . PRO   A 1 11  ? -1.33732  -0.85405  2.84670   1.000 31.73953 ? 8   PRO   A CG  1 
ATOM   15   C CD  . PRO   A 1 11  ? -0.41763  -1.97436  2.50393   1.000 33.15521 ? 8   PRO   A CD  1 
ATOM   16   N N   . PRO   A 1 12  ? 1.97196   1.95419   1.44380   1.000 25.74725 ? 9   PRO   A N   1 
ATOM   17   C CA  . PRO   A 1 12  ? 3.33188   2.51710   1.44023   1.000 27.57850 ? 9   PRO   A CA  1 
ATOM   18   C C   . PRO   A 1 12  ? 4.06814   2.27977   2.75138   1.000 26.37434 ? 9   PRO   A C   1 
ATOM   19   O O   . PRO   A 1 12  ? 3.53171   2.50249   3.83873   1.000 23.73777 ? 9   PRO   A O   1 
ATOM   20   C CB  . PRO   A 1 12  ? 3.09274   4.01026   1.19117   1.000 31.46213 ? 9   PRO   A CB  1 
ATOM   21   C CG  . PRO   A 1 12  ? 1.78951   4.06196   0.48967   1.000 26.65280 ? 9   PRO   A CG  1 
ATOM   22   C CD  . PRO   A 1 12  ? 0.96485   2.97633   1.10546   1.000 28.29603 ? 9   PRO   A CD  1 
ATOM   23   N N   . GLY   A 1 13  ? 5.31411   1.82302   2.63512   1.000 23.19049 ? 10  GLY   A N   1 
ATOM   24   C CA  . GLY   A 1 13  ? 6.15134   1.56302   3.77958   1.000 22.88210 ? 10  GLY   A CA  1 
ATOM   25   C C   . GLY   A 1 13  ? 6.09456   0.14552   4.31146   1.000 17.42914 ? 10  GLY   A C   1 
ATOM   26   O O   . GLY   A 1 13  ? 6.98249   -0.23742  5.07858   1.000 18.34504 ? 10  GLY   A O   1 
ATOM   27   N N   . TRP   A 1 14  ? 5.09418   -0.64173  3.91753   1.000 20.75679 ? 11  TRP   A N   1 
ATOM   28   C CA  . TRP   A 1 14  ? 4.88950   -1.97395  4.48043   1.000 19.77061 ? 11  TRP   A CA  1 
ATOM   29   C C   . TRP   A 1 14  ? 5.70035   -3.03535  3.75013   1.000 20.93876 ? 11  TRP   A C   1 
ATOM   30   O O   . TRP   A 1 14  ? 5.81439   -3.01700  2.51965   1.000 27.01761 ? 11  TRP   A O   1 
ATOM   31   C CB  . TRP   A 1 14  ? 3.40969   -2.35230  4.43400   1.000 19.90303 ? 11  TRP   A CB  1 
ATOM   32   C CG  . TRP   A 1 14  ? 2.58257   -1.67786  5.47609   1.000 17.22689 ? 11  TRP   A CG  1 
ATOM   33   C CD1 . TRP   A 1 14  ? 1.74641   -0.61559  5.29675   1.000 17.62622 ? 11  TRP   A CD1 1 
ATOM   34   C CD2 . TRP   A 1 14  ? 2.50842   -2.02209  6.86461   1.000 18.13816 ? 11  TRP   A CD2 1 
ATOM   35   N NE1 . TRP   A 1 14  ? 1.15431   -0.27713  6.48911   1.000 19.62960 ? 11  TRP   A NE1 1 
ATOM   36   C CE2 . TRP   A 1 14  ? 1.60445   -1.12422  7.46763   1.000 18.11980 ? 11  TRP   A CE2 1 
ATOM   37   C CE3 . TRP   A 1 14  ? 3.12694   -2.99962  7.66151   1.000 17.13446 ? 11  TRP   A CE3 1 
ATOM   38   C CZ2 . TRP   A 1 14  ? 1.28892   -1.17854  8.82782   1.000 18.41583 ? 11  TRP   A CZ2 1 
ATOM   39   C CZ3 . TRP   A 1 14  ? 2.80966   -3.05681  9.00666   1.000 18.71213 ? 11  TRP   A CZ3 1 
ATOM   40   C CH2 . TRP   A 1 14  ? 1.89929   -2.14515  9.58103   1.000 17.17334 ? 11  TRP   A CH2 1 
ATOM   41   N N   . GLU   A 1 15  ? 6.24232   -3.97461  4.52018   1.000 18.80535 ? 12  GLU   A N   1 
ATOM   42   C CA  . GLU   A 1 15  ? 6.94843   -5.12782  3.98260   1.000 22.77945 ? 12  GLU   A CA  1 
ATOM   43   C C   . GLU   A 1 15  ? 6.53009   -6.37004  4.75645   1.000 22.26574 ? 12  GLU   A C   1 
ATOM   44   O O   . GLU   A 1 15  ? 6.09425   -6.28649  5.90675   1.000 20.43383 ? 12  GLU   A O   1 
ATOM   45   C CB  . GLU   A 1 15  ? 8.46965   -4.93836  4.04702   1.000 24.19970 ? 12  GLU   A CB  1 
ATOM   46   C CG  . GLU   A 1 15  ? 8.96290   -3.81324  3.13752   1.000 34.37532 ? 12  GLU   A CG  1 
ATOM   47   C CD  . GLU   A 1 15  ? 10.46063  -3.61703  3.19118   1.000 44.26515 ? 12  GLU   A CD  1 
ATOM   48   O OE1 . GLU   A 1 15  ? 11.07090  -3.95973  4.22326   1.000 51.82415 ? 12  GLU   A OE1 1 
ATOM   49   O OE2 . GLU   A 1 15  ? 11.02861  -3.11426  2.19836   1.000 60.11252 ? 12  GLU   A OE2 1 
ATOM   50   N N   . LYS   A 1 16  ? 6.65954   -7.52069  4.10645   1.000 21.65836 ? 13  LYS   A N   1 
ATOM   51   C CA  . LYS   A 1 16  ? 6.34737   -8.81836  4.69283   1.000 20.23465 ? 13  LYS   A CA  1 
ATOM   52   C C   . LYS   A 1 16  ? 7.63258   -9.51443  5.13300   1.000 22.08130 ? 13  LYS   A C   1 
ATOM   53   O O   . LYS   A 1 16  ? 8.67704   -9.38676  4.48818   1.000 25.20448 ? 13  LYS   A O   1 
ATOM   54   C CB  . LYS   A 1 16  ? 5.59436   -9.67578  3.67102   1.000 24.11507 ? 13  LYS   A CB  1 
ATOM   55   C CG  . LYS   A 1 16  ? 4.93205   -10.92751 4.21025   1.000 22.66700 ? 13  LYS   A CG  1 
ATOM   56   C CD  . LYS   A 1 16  ? 4.25797   -11.68846 3.07430   1.000 25.60193 ? 13  LYS   A CD  1 
ATOM   57   C CE  . LYS   A 1 16  ? 3.26975   -12.72695 3.59204   1.000 33.26099 ? 13  LYS   A CE  1 
ATOM   58   N NZ  . LYS   A 1 16  ? 2.58118   -13.44305 2.48058   1.000 31.89289 ? 13  LYS   A NZ  1 
ATOM   59   N N   . ALA   A 1 17  ? 7.55166   -10.25947 6.23649   1.000 18.07146 ? 14  ALA   A N   1 
ATOM   60   C CA  . ALA   A 1 17  ? 8.71453   -10.91813 6.81301   1.000 17.19710 ? 14  ALA   A CA  1 
ATOM   61   C C   . ALA   A 1 17  ? 8.28135   -12.20177 7.51046   1.000 17.97954 ? 14  ALA   A C   1 
ATOM   62   O O   . ALA   A 1 17  ? 7.09614   -12.41823 7.75638   1.000 20.53010 ? 14  ALA   A O   1 
ATOM   63   C CB  . ALA   A 1 17  ? 9.43523   -9.98473  7.79071   1.000 29.31638 ? 14  ALA   A CB  1 
ATOM   64   N N   . MET   A 1 18  ? 9.25206   -13.05592 7.83748   1.000 23.90930 ? 15  MET   A N   1 
ATOM   65   C CA  . MET   A 1 18  ? 9.00475   -14.22416 8.67771   1.000 19.01296 ? 15  MET   A CA  1 
ATOM   66   C C   . MET   A 1 18  ? 9.89208   -14.15324 9.91102   1.000 23.12812 ? 15  MET   A C   1 
ATOM   67   O O   . MET   A 1 18  ? 11.09983  -13.90697 9.80769   1.000 21.77268 ? 15  MET   A O   1 
ATOM   68   C CB  . MET   A 1 18  ? 9.23390   -15.55490 7.94116   1.000 24.85314 ? 15  MET   A CB  1 
ATOM   69   C CG  . MET   A 1 18  ? 8.50271   -16.77520 8.59592   1.000 20.30709 ? 15  MET   A CG  1 
ATOM   70   S SD  . MET   A 1 18  ? 8.86797   -18.36664 7.82654   1.000 52.97117 ? 15  MET   A SD  1 
ATOM   71   C CE  . MET   A 1 18  ? 10.44103  -18.75728 8.58543   1.000 37.77056 ? 15  MET   A CE  1 
ATOM   72   N N   . SER   A 1 19  ? 9.28330   -14.36650 11.07259  1.000 18.20233 ? 16  SER   A N   1 
ATOM   73   C CA  . SER   A 1 19  ? 10.01168  -14.40643 12.33062  1.000 16.89558 ? 16  SER   A CA  1 
ATOM   74   C C   . SER   A 1 19  ? 10.93978  -15.61103 12.37142  1.000 18.68536 ? 16  SER   A C   1 
ATOM   75   O O   . SER   A 1 19  ? 10.50168  -16.75263 12.20140  1.000 19.83053 ? 16  SER   A O   1 
ATOM   76   C CB  . SER   A 1 19  ? 9.02870   -14.47898 13.49629  1.000 19.61338 ? 16  SER   A CB  1 
ATOM   77   O OG  . SER   A 1 19  ? 9.70811   -14.84421 14.68302  1.000 23.21253 ? 16  SER   A OG  1 
ATOM   78   N N   . ARG   A 1 20  ? 12.21945  -15.36322 12.63586  1.000 18.21059 ? 17  ARG   A N   1 
ATOM   79   C CA  . ARG   A 1 20  ? 13.15798  -16.46926 12.76481  1.000 22.32855 ? 17  ARG   A CA  1 
ATOM   80   C C   . ARG   A 1 20  ? 12.85939  -17.30396 14.00321  1.000 24.09883 ? 17  ARG   A C   1 
ATOM   81   O O   . ARG   A 1 20  ? 12.94875  -18.53629 13.95875  1.000 27.08977 ? 17  ARG   A O   1 
ATOM   82   C CB  . ARG   A 1 20  ? 14.58856  -15.93401 12.80188  1.000 20.50519 ? 17  ARG   A CB  1 
ATOM   83   C CG  . ARG   A 1 20  ? 15.04247  -15.30991 11.48425  1.000 20.98491 ? 17  ARG   A CG  1 
ATOM   84   C CD  . ARG   A 1 20  ? 16.32129  -14.52368 11.68336  1.000 19.33465 ? 17  ARG   A CD  1 
ATOM   85   N NE  . ARG   A 1 20  ? 16.08053  -13.37931 12.54943  1.000 23.01270 ? 17  ARG   A NE  1 
ATOM   86   C CZ  . ARG   A 1 20  ? 17.02576  -12.60220 13.05853  1.000 24.20255 ? 17  ARG   A CZ  1 
ATOM   87   N NH1 . ARG   A 1 20  ? 18.30755  -12.80871 12.79680  1.000 24.93397 ? 17  ARG   A NH1 1 
ATOM   88   N NH2 . ARG   A 1 20  ? 16.67574  -11.59570 13.85295  1.000 28.12341 ? 17  ARG   A NH2 1 
ATOM   89   N N   . SER   A 1 21  ? 12.45857  -16.65647 15.10204  1.000 19.06094 ? 18  SER   A N   1 
ATOM   90   C CA  . SER   A 1 21  ? 12.30477  -17.36213 16.37359  1.000 21.19056 ? 18  SER   A CA  1 
ATOM   91   C C   . SER   A 1 21  ? 11.03635  -18.20473 16.43666  1.000 21.82350 ? 18  SER   A C   1 
ATOM   92   O O   . SER   A 1 21  ? 11.02842  -19.24313 17.10825  1.000 24.07845 ? 18  SER   A O   1 
ATOM   93   C CB  . SER   A 1 21  ? 12.32002  -16.36717 17.53909  1.000 25.22331 ? 18  SER   A CB  1 
ATOM   94   O OG  . SER   A 1 21  ? 11.23774  -15.45322 17.47567  1.000 25.64165 ? 18  SER   A OG  1 
ATOM   95   N N   . SER   A 1 22  ? 9.96454   -17.78286 15.75926  1.000 18.31849 ? 19  SER   A N   1 
ATOM   96   C CA  . SER   A 1 22  ? 8.67398   -18.45639 15.84342  1.000 17.32148 ? 19  SER   A CA  1 
ATOM   97   C C   . SER   A 1 22  ? 8.17053   -19.03204 14.53316  1.000 16.49167 ? 19  SER   A C   1 
ATOM   98   O O   . SER   A 1 22  ? 7.25842   -19.87134 14.56434  1.000 19.73272 ? 19  SER   A O   1 
ATOM   99   C CB  . SER   A 1 22  ? 7.59974   -17.49367 16.35925  1.000 17.70658 ? 19  SER   A CB  1 
ATOM   100  O OG  . SER   A 1 22  ? 7.32897   -16.50805 15.37073  1.000 17.18432 ? 19  SER   A OG  1 
ATOM   101  N N   . GLY   A 1 23  ? 8.69789   -18.59507 13.39134  1.000 18.28414 ? 20  GLY   A N   1 
ATOM   102  C CA  . GLY   A 1 23  ? 8.21681   -19.05567 12.10852  1.000 17.10604 ? 20  GLY   A CA  1 
ATOM   103  C C   . GLY   A 1 23  ? 6.95656   -18.38879 11.62053  1.000 15.94503 ? 20  GLY   A C   1 
ATOM   104  O O   . GLY   A 1 23  ? 6.50087   -18.70324 10.52012  1.000 19.39279 ? 20  GLY   A O   1 
ATOM   105  N N   . ARG   A 1 24  ? 6.38542   -17.46543 12.39027  1.000 15.66606 ? 21  ARG   A N   1 
ATOM   106  C CA  . ARG   A 1 24  ? 5.16744   -16.78980 11.98294  1.000 15.82918 ? 21  ARG   A CA  1 
ATOM   107  C C   . ARG   A 1 24  ? 5.47968   -15.59232 11.09114  1.000 17.70514 ? 21  ARG   A C   1 
ATOM   108  O O   . ARG   A 1 24  ? 6.42433   -14.83838 11.34907  1.000 16.93584 ? 21  ARG   A O   1 
ATOM   109  C CB  . ARG   A 1 24  ? 4.37800   -16.34468 13.22088  1.000 16.42879 ? 21  ARG   A CB  1 
ATOM   110  C CG  . ARG   A 1 24  ? 2.95475   -15.91904 12.92072  1.000 16.91811 ? 21  ARG   A CG  1 
ATOM   111  C CD  . ARG   A 1 24  ? 2.28292   -15.29955 14.13286  1.000 15.53482 ? 21  ARG   A CD  1 
ATOM   112  N NE  . ARG   A 1 24  ? 1.82754   -16.26915 15.13162  1.000 12.94550 ? 21  ARG   A NE  1 
ATOM   113  C CZ  . ARG   A 1 24  ? 1.28069   -15.91607 16.29000  1.000 14.44273 ? 21  ARG   A CZ  1 
ATOM   114  N NH1 . ARG   A 1 24  ? 1.19641   -14.64452 16.65464  1.000 14.11825 ? 21  ARG   A NH1 1 
ATOM   115  N NH2 . ARG   A 1 24  ? 0.77908   -16.85712 17.09305  1.000 13.33814 ? 21  ARG   A NH2 1 
ATOM   116  N N   . VAL   A 1 25  ? 4.67327   -15.43210 10.03992  1.000 15.02009 ? 22  VAL   A N   1 
ATOM   117  C CA  . VAL   A 1 25  ? 4.75957   -14.27193 9.15578   1.000 15.22771 ? 22  VAL   A CA  1 
ATOM   118  C C   . VAL   A 1 25  ? 4.32076   -13.01687 9.89551   1.000 16.44384 ? 22  VAL   A C   1 
ATOM   119  O O   . VAL   A 1 25  ? 3.36886   -13.03744 10.68472  1.000 16.51748 ? 22  VAL   A O   1 
ATOM   120  C CB  . VAL   A 1 25  ? 3.88696   -14.50188 7.91200   1.000 18.21439 ? 22  VAL   A CB  1 
ATOM   121  C CG1 . VAL   A 1 25  ? 3.63094   -13.18774 7.13489   1.000 20.47440 ? 22  VAL   A CG1 1 
ATOM   122  C CG2 . VAL   A 1 25  ? 4.53301   -15.56441 7.01940   1.000 19.92703 ? 22  VAL   A CG2 1 
ATOM   123  N N   . TYR   A 1 26  ? 4.98896   -11.90089 9.61452   1.000 15.50130 ? 23  TYR   A N   1 
ATOM   124  C CA  . TYR   A 1 26  ? 4.54001   -10.61883 10.12535  1.000 14.13041 ? 23  TYR   A CA  1 
ATOM   125  C C   . TYR   A 1 26  ? 4.78080   -9.53724  9.08415   1.000 17.13421 ? 23  TYR   A C   1 
ATOM   126  O O   . TYR   A 1 26  ? 5.39762   -9.76577  8.04287   1.000 19.01031 ? 23  TYR   A O   1 
ATOM   127  C CB  . TYR   A 1 26  ? 5.22924   -10.25596 11.44598  1.000 14.93229 ? 23  TYR   A CB  1 
ATOM   128  C CG  . TYR   A 1 26  ? 6.72051   -9.99808  11.35677  1.000 16.26255 ? 23  TYR   A CG  1 
ATOM   129  C CD1 . TYR   A 1 26  ? 7.63064   -11.04606 11.37772  1.000 16.68371 ? 23  TYR   A CD1 1 
ATOM   130  C CD2 . TYR   A 1 26  ? 7.21865   -8.70022  11.28012  1.000 18.53792 ? 23  TYR   A CD2 1 
ATOM   131  C CE1 . TYR   A 1 26  ? 8.99951   -10.81768 11.31813  1.000 19.63812 ? 23  TYR   A CE1 1 
ATOM   132  C CE2 . TYR   A 1 26  ? 8.58565   -8.46391  11.20947  1.000 17.45332 ? 23  TYR   A CE2 1 
ATOM   133  C CZ  . TYR   A 1 26  ? 9.47099   -9.52398  11.22726  1.000 22.22904 ? 23  TYR   A CZ  1 
ATOM   134  O OH  . TYR   A 1 26  ? 10.83925  -9.28726  11.16422  1.000 23.75859 ? 23  TYR   A OH  1 
ATOM   135  N N   . TYR   A 1 27  ? 4.28146   -8.34268  9.39182   1.000 16.40747 ? 24  TYR   A N   1 
ATOM   136  C CA  . TYR   A 1 27  ? 4.39365   -7.18622  8.51933   1.000 17.03221 ? 24  TYR   A CA  1 
ATOM   137  C C   . TYR   A 1 27  ? 5.00166   -6.04226  9.30560   1.000 17.44252 ? 24  TYR   A C   1 
ATOM   138  O O   . TYR   A 1 27  ? 4.69754   -5.86178  10.48813  1.000 16.40892 ? 24  TYR   A O   1 
ATOM   139  C CB  . TYR   A 1 27  ? 3.03847   -6.78927  7.97242   1.000 18.10078 ? 24  TYR   A CB  1 
ATOM   140  C CG  . TYR   A 1 27  ? 2.36096   -7.92495  7.24824   1.000 19.94857 ? 24  TYR   A CG  1 
ATOM   141  C CD1 . TYR   A 1 27  ? 1.60901   -8.86613  7.93904   1.000 19.75341 ? 24  TYR   A CD1 1 
ATOM   142  C CD2 . TYR   A 1 27  ? 2.50514   -8.07072  5.87803   1.000 25.88939 ? 24  TYR   A CD2 1 
ATOM   143  C CE1 . TYR   A 1 27  ? 1.00956   -9.91200  7.28503   1.000 21.98815 ? 24  TYR   A CE1 1 
ATOM   144  C CE2 . TYR   A 1 27  ? 1.90462   -9.11588  5.21251   1.000 23.43852 ? 24  TYR   A CE2 1 
ATOM   145  C CZ  . TYR   A 1 27  ? 1.15356   -10.03010 5.92449   1.000 25.21650 ? 24  TYR   A CZ  1 
ATOM   146  O OH  . TYR   A 1 27  ? 0.54239   -11.07659 5.27412   1.000 29.38804 ? 24  TYR   A OH  1 
ATOM   147  N N   . PHE   A 1 28  ? 5.87777   -5.28015  8.66005   1.000 16.42658 ? 25  PHE   A N   1 
ATOM   148  C CA  . PHE   A 1 28  ? 6.47651   -4.14016  9.33668   1.000 16.71291 ? 25  PHE   A CA  1 
ATOM   149  C C   . PHE   A 1 28  ? 6.54105   -2.96622  8.37705   1.000 17.74521 ? 25  PHE   A C   1 
ATOM   150  O O   . PHE   A 1 28  ? 6.62940   -3.13872  7.15857   1.000 17.62151 ? 25  PHE   A O   1 
ATOM   151  C CB  . PHE   A 1 28  ? 7.86590   -4.46604  9.92159   1.000 18.87699 ? 25  PHE   A CB  1 
ATOM   152  C CG  . PHE   A 1 28  ? 8.94802   -4.69739  8.89800   1.000 24.86522 ? 25  PHE   A CG  1 
ATOM   153  C CD1 . PHE   A 1 28  ? 9.71181   -3.63934  8.42324   1.000 25.72971 ? 25  PHE   A CD1 1 
ATOM   154  C CD2 . PHE   A 1 28  ? 9.24282   -5.97971  8.46059   1.000 27.34749 ? 25  PHE   A CD2 1 
ATOM   155  C CE1 . PHE   A 1 28  ? 10.72619  -3.85211  7.50848   1.000 29.97895 ? 25  PHE   A CE1 1 
ATOM   156  C CE2 . PHE   A 1 28  ? 10.25996  -6.20019  7.53999   1.000 30.17534 ? 25  PHE   A CE2 1 
ATOM   157  C CZ  . PHE   A 1 28  ? 10.99939  -5.13017  7.06598   1.000 28.95899 ? 25  PHE   A CZ  1 
ATOM   158  N N   . ASN   A 1 29  ? 6.48885   -1.76384  8.94408   1.000 17.01945 ? 26  ASN   A N   1 
ATOM   159  C CA  . ASN   A 1 29  ? 6.46955   -0.53086  8.16569   1.000 16.74235 ? 26  ASN   A CA  1 
ATOM   160  C C   . ASN   A 1 29  ? 7.72212   0.26883   8.49535   1.000 14.96543 ? 26  ASN   A C   1 
ATOM   161  O O   . ASN   A 1 29  ? 7.93855   0.64048   9.65230   1.000 16.00662 ? 26  ASN   A O   1 
ATOM   162  C CB  . ASN   A 1 29  ? 5.19984   0.28378   8.45350   1.000 16.36715 ? 26  ASN   A CB  1 
ATOM   163  C CG  . ASN   A 1 29  ? 5.02747   1.44116   7.48713   1.000 17.82934 ? 26  ASN   A CG  1 
ATOM   164  O OD1 . ASN   A 1 29  ? 5.86868   2.32763   7.43074   1.000 15.11173 ? 26  ASN   A OD1 1 
ATOM   165  N ND2 . ASN   A 1 29  ? 3.94082   1.43381   6.72357   1.000 17.16823 ? 26  ASN   A ND2 1 
ATOM   166  N N   . HIS   A 1 30  ? 8.55493   0.52588   7.48289   1.000 15.25189 ? 27  HIS   A N   1 
ATOM   167  C CA  . HIS   A 1 30  ? 9.82778   1.18745   7.73731   1.000 16.22960 ? 27  HIS   A CA  1 
ATOM   168  C C   . HIS   A 1 30  ? 9.70234   2.70156   7.84235   1.000 16.84379 ? 27  HIS   A C   1 
ATOM   169  O O   . HIS   A 1 30  ? 10.70188  3.36041   8.15406   1.000 16.20919 ? 27  HIS   A O   1 
ATOM   170  C CB  . HIS   A 1 30  ? 10.85901  0.81629   6.65825   1.000 21.58690 ? 27  HIS   A CB  1 
ATOM   171  C CG  . HIS   A 1 30  ? 10.47759  1.22996   5.26783   1.000 23.83727 ? 27  HIS   A CG  1 
ATOM   172  N ND1 . HIS   A 1 30  ? 10.68777  2.50394   4.78423   1.000 29.93870 ? 27  HIS   A ND1 1 
ATOM   173  C CD2 . HIS   A 1 30  ? 9.92754   0.52812   4.24708   1.000 27.96333 ? 27  HIS   A CD2 1 
ATOM   174  C CE1 . HIS   A 1 30  ? 10.26656  2.57535   3.53455   1.000 24.87084 ? 27  HIS   A CE1 1 
ATOM   175  N NE2 . HIS   A 1 30  ? 9.80130   1.39001   3.18475   1.000 27.88814 ? 27  HIS   A NE2 1 
ATOM   176  N N   . ILE   A 1 31  ? 8.51350   3.25579   7.62731   1.000 15.21781 ? 28  ILE   A N   1 
ATOM   177  C CA  . ILE   A 1 31  ? 8.27154   4.68376   7.81401   1.000 15.04523 ? 28  ILE   A CA  1 
ATOM   178  C C   . ILE   A 1 31  ? 7.68001   4.97504   9.18915   1.000 14.95365 ? 28  ILE   A C   1 
ATOM   179  O O   . ILE   A 1 31  ? 8.05651   5.95449   9.84192   1.000 16.06850 ? 28  ILE   A O   1 
ATOM   180  C CB  . ILE   A 1 31  ? 7.35721   5.22760   6.69707   1.000 13.69309 ? 28  ILE   A CB  1 
ATOM   181  C CG1 . ILE   A 1 31  ? 7.87558   4.79952   5.31483   1.000 15.64727 ? 28  ILE   A CG1 1 
ATOM   182  C CG2 . ILE   A 1 31  ? 7.26700   6.75857   6.78727   1.000 15.38018 ? 28  ILE   A CG2 1 
ATOM   183  C CD1 . ILE   A 1 31  ? 6.94411   5.14553   4.19249   1.000 20.37465 ? 28  ILE   A CD1 1 
ATOM   184  N N   . THR   A 1 32  ? 6.76145   4.12535   9.65046   1.000 14.22281 ? 29  THR   A N   1 
ATOM   185  C CA  . THR   A 1 32  ? 6.10371   4.31619   10.93872  1.000 14.97493 ? 29  THR   A CA  1 
ATOM   186  C C   . THR   A 1 32  ? 6.70252   3.47335   12.05550  1.000 14.42931 ? 29  THR   A C   1 
ATOM   187  O O   . THR   A 1 32  ? 6.36511   3.70485   13.22290  1.000 13.90973 ? 29  THR   A O   1 
ATOM   188  C CB  . THR   A 1 32  ? 4.61917   3.96639   10.84074  1.000 12.49288 ? 29  THR   A CB  1 
ATOM   189  O OG1 . THR   A 1 32  ? 4.51421   2.54977   10.65694  1.000 15.21289 ? 29  THR   A OG1 1 
ATOM   190  C CG2 . THR   A 1 32  ? 3.96184   4.65459   9.65595   1.000 15.33018 ? 29  THR   A CG2 1 
ATOM   191  N N   . ASN   A 1 33  ? 7.53731   2.48658   11.71893  1.000 13.16545 ? 30  ASN   A N   1 
ATOM   192  C CA  . ASN   A 1 33  ? 8.17503   1.53789   12.63023  1.000 12.75308 ? 30  ASN   A CA  1 
ATOM   193  C C   . ASN   A 1 33  ? 7.16871   0.59090   13.28043  1.000 13.80753 ? 30  ASN   A C   1 
ATOM   194  O O   . ASN   A 1 33  ? 7.51466   -0.09621  14.24133  1.000 15.36577 ? 30  ASN   A O   1 
ATOM   195  C CB  . ASN   A 1 33  ? 9.02126   2.24617   13.69532  1.000 14.53411 ? 30  ASN   A CB  1 
ATOM   196  C CG  . ASN   A 1 33  ? 10.27174  2.87239   13.10592  1.000 19.11101 ? 30  ASN   A CG  1 
ATOM   197  O OD1 . ASN   A 1 33  ? 10.70045  2.48965   12.01749  1.000 18.04428 ? 30  ASN   A OD1 1 
ATOM   198  N ND2 . ASN   A 1 33  ? 10.86738  3.82526   13.81796  1.000 18.07064 ? 30  ASN   A ND2 1 
ATOM   199  N N   . ALA   A 1 34  ? 5.94711   0.51485   12.75283  1.000 15.19886 ? 31  ALA   A N   1 
ATOM   200  C CA  . ALA   A 1 34  ? 4.95620   -0.44309  13.23077  1.000 15.95077 ? 31  ALA   A CA  1 
ATOM   201  C C   . ALA   A 1 34  ? 5.29925   -1.85643  12.76546  1.000 20.09398 ? 31  ALA   A C   1 
ATOM   202  O O   . ALA   A 1 34  ? 5.87886   -2.05448  11.69611  1.000 17.48899 ? 31  ALA   A O   1 
ATOM   203  C CB  . ALA   A 1 34  ? 3.56644   -0.06202  12.71444  1.000 18.09491 ? 31  ALA   A CB  1 
ATOM   204  N N   . SER   A 1 35  ? 4.93160   -2.84792  13.57986  1.000 16.82407 ? 32  SER   A N   1 
ATOM   205  C CA  . SER   A 1 35  ? 5.07872   -4.24875  13.19188  1.000 21.46128 ? 32  SER   A CA  1 
ATOM   206  C C   . SER   A 1 35  ? 3.90406   -5.01712  13.76981  1.000 25.16309 ? 32  SER   A C   1 
ATOM   207  O O   . SER   A 1 35  ? 3.50510   -4.76490  14.90742  1.000 26.37517 ? 32  SER   A O   1 
ATOM   208  C CB  . SER   A 1 35  ? 6.39409   -4.85248  13.68782  1.000 26.00934 ? 32  SER   A CB  1 
ATOM   209  O OG  . SER   A 1 35  ? 6.45919   -4.81182  15.09934  1.000 35.80183 ? 32  SER   A OG  1 
ATOM   210  N N   . GLN   A 1 36  ? 3.35709   -5.95490  12.99388  1.000 20.23286 ? 33  GLN   A N   1 
ATOM   211  C CA  . GLN   A 1 36  ? 2.14382   -6.64194  13.41330  1.000 20.41687 ? 33  GLN   A CA  1 
ATOM   212  C C   . GLN   A 1 36  ? 2.06796   -8.00566  12.74204  1.000 19.40558 ? 33  GLN   A C   1 
ATOM   213  O O   . GLN   A 1 36  ? 2.56029   -8.19172  11.62382  1.000 17.23685 ? 33  GLN   A O   1 
ATOM   214  C CB  . GLN   A 1 36  ? 0.88753   -5.82265  13.08154  1.000 21.33796 ? 33  GLN   A CB  1 
ATOM   215  C CG  . GLN   A 1 36  ? 0.78835   -5.37729  11.63948  1.000 22.68006 ? 33  GLN   A CG  1 
ATOM   216  C CD  . GLN   A 1 36  ? -0.35828  -4.40812  11.41730  1.000 28.93839 ? 33  GLN   A CD  1 
ATOM   217  O OE1 . GLN   A 1 36  ? -1.31663  -4.70685  10.70256  1.000 29.34270 ? 33  GLN   A OE1 1 
ATOM   218  N NE2 . GLN   A 1 36  ? -0.26253  -3.23551  12.03428  1.000 22.31345 ? 33  GLN   A NE2 1 
ATOM   219  N N   . TRP   A 1 37  ? 1.46195   -8.96196  13.45638  1.000 22.80653 ? 34  TRP   A N   1 
ATOM   220  C CA  . TRP   A 1 37  ? 1.12544   -10.24926 12.85377  1.000 21.13212 ? 34  TRP   A CA  1 
ATOM   221  C C   . TRP   A 1 37  ? -0.00035  -10.10796 11.84614  1.000 20.82545 ? 34  TRP   A C   1 
ATOM   222  O O   . TRP   A 1 37  ? -0.05301  -10.84122 10.85191  1.000 23.52673 ? 34  TRP   A O   1 
ATOM   223  C CB  . TRP   A 1 37  ? 0.71042   -11.25328 13.93796  1.000 15.95556 ? 34  TRP   A CB  1 
ATOM   224  C CG  . TRP   A 1 37  ? 1.66119   -11.35356 15.08985  1.000 19.51009 ? 34  TRP   A CG  1 
ATOM   225  C CD1 . TRP   A 1 37  ? 1.40993   -11.03264 16.39665  1.000 18.23945 ? 34  TRP   A CD1 1 
ATOM   226  C CD2 . TRP   A 1 37  ? 3.01015   -11.81197 15.04383  1.000 19.46797 ? 34  TRP   A CD2 1 
ATOM   227  N NE1 . TRP   A 1 37  ? 2.52350   -11.26360 17.16063  1.000 21.54585 ? 34  TRP   A NE1 1 
ATOM   228  C CE2 . TRP   A 1 37  ? 3.51837   -11.75437 16.35734  1.000 18.29663 ? 34  TRP   A CE2 1 
ATOM   229  C CE3 . TRP   A 1 37  ? 3.84041   -12.27658 14.01777  1.000 17.12222 ? 34  TRP   A CE3 1 
ATOM   230  C CZ2 . TRP   A 1 37  ? 4.82578   -12.11771 16.66750  1.000 20.38486 ? 34  TRP   A CZ2 1 
ATOM   231  C CZ3 . TRP   A 1 37  ? 5.12308   -12.65139 14.32282  1.000 18.25215 ? 34  TRP   A CZ3 1 
ATOM   232  C CH2 . TRP   A 1 37  ? 5.61382   -12.56785 15.63935  1.000 20.93450 ? 34  TRP   A CH2 1 
ATOM   233  N N   . GLU   A 1 38  ? -0.91056  -9.17099  12.08022  1.000 27.83590 ? 35  GLU   A N   1 
ATOM   234  C CA  . GLU   A 1 38  ? -2.07378  -9.06531  11.22483  1.000 27.22773 ? 35  GLU   A CA  1 
ATOM   235  C C   . GLU   A 1 38  ? -1.73035  -8.35760  9.92473   1.000 27.64299 ? 35  GLU   A C   1 
ATOM   236  O O   . GLU   A 1 38  ? -0.89006  -7.45279  9.87673   1.000 27.81518 ? 35  GLU   A O   1 
ATOM   237  C CB  . GLU   A 1 38  ? -3.21242  -8.33439  11.93242  1.000 34.37939 ? 35  GLU   A CB  1 
ATOM   238  C CG  . GLU   A 1 38  ? -2.77859  -7.28796  12.91044  1.000 36.11818 ? 35  GLU   A CG  1 
ATOM   239  C CD  . GLU   A 1 38  ? -2.45205  -7.86331  14.27924  1.000 32.13762 ? 35  GLU   A CD  1 
ATOM   240  O OE1 . GLU   A 1 38  ? -3.31476  -8.54199  14.87236  1.000 47.32366 ? 35  GLU   A OE1 1 
ATOM   241  O OE2 . GLU   A 1 38  ? -1.32339  -7.63051  14.75500  1.000 23.48250 ? 35  GLU   A OE2 1 
ATOM   242  N N   . ARG   A 1 39  ? -2.40562  -8.77485  8.87734   1.000 26.03488 ? 36  ARG   A N   1 
ATOM   243  C CA  . ARG   A 1 39  ? -2.18816  -8.21336  7.55685   1.000 25.83192 ? 36  ARG   A CA  1 
ATOM   244  C C   . ARG   A 1 39  ? -2.73040  -6.78905  7.51067   1.000 29.67664 ? 36  ARG   A C   1 
ATOM   245  O O   . ARG   A 1 39  ? -3.85905  -6.54820  7.95552   1.000 30.00295 ? 36  ARG   A O   1 
ATOM   246  C CB  . ARG   A 1 39  ? -2.88197  -9.08286  6.51965   1.000 34.59695 ? 36  ARG   A CB  1 
ATOM   247  C CG  . ARG   A 1 39  ? -2.58560  -8.72676  5.09093   1.000 30.18354 ? 36  ARG   A CG  1 
ATOM   248  C CD  . ARG   A 1 39  ? -3.48616  -9.52112  4.16027   1.000 41.08227 ? 36  ARG   A CD  1 
ATOM   249  N NE  . ARG   A 1 39  ? -3.78722  -10.84429 4.69646   1.000 40.15388 ? 36  ARG   A NE  1 
ATOM   250  C CZ  . ARG   A 1 39  ? -3.15590  -11.95993 4.35535   1.000 43.55103 ? 36  ARG   A CZ  1 
ATOM   251  N NH1 . ARG   A 1 39  ? -2.18814  -11.95997 3.44988   1.000 44.47558 ? 36  ARG   A NH1 1 
ATOM   252  N NH2 . ARG   A 1 39  ? -3.50288  -13.10523 4.93974   1.000 34.09114 ? 36  ARG   A NH2 1 
ATOM   253  N N   . PRO   A 1 40  ? -1.96907  -5.82829  6.99294   1.000 24.23017 ? 37  PRO   A N   1 
ATOM   254  C CA  . PRO   A 1 40  ? -2.43687  -4.43586  6.99338   1.000 24.07227 ? 37  PRO   A CA  1 
ATOM   255  C C   . PRO   A 1 40  ? -3.60809  -4.22976  6.04683   1.000 29.40289 ? 37  PRO   A C   1 
ATOM   256  O O   . PRO   A 1 40  ? -3.69799  -4.88262  5.00558   1.000 29.78317 ? 37  PRO   A O   1 
ATOM   257  C CB  . PRO   A 1 40  ? -1.20485  -3.64732  6.52225   1.000 24.42740 ? 37  PRO   A CB  1 
ATOM   258  C CG  . PRO   A 1 40  ? -0.03595  -4.57573  6.73346   1.000 28.50932 ? 37  PRO   A CG  1 
ATOM   259  C CD  . PRO   A 1 40  ? -0.57235  -5.95055  6.53798   1.000 26.70155 ? 37  PRO   A CD  1 
ATOM   260  N N   . SER   A 1 41  ? -4.52191  -3.34131  6.45626   1.000 29.57225 ? 38  SER   A N   1 
ATOM   261  C CA  . SER   A 1 41  ? -5.48617  -2.61997  5.59880   1.000 36.69523 ? 38  SER   A CA  1 
ATOM   262  C C   . SER   A 1 41  ? -6.65017  -2.13078  6.45763   1.000 40.09228 ? 38  SER   A C   1 
ATOM   263  O O   . SER   A 1 41  ? -6.65072  -2.30861  7.67619   1.000 37.78209 ? 38  SER   A O   1 
ATOM   264  C CB  . SER   A 1 41  ? -6.02935  -3.45905  4.44107   1.000 38.76868 ? 38  SER   A CB  1 
ATOM   265  O OG  . SER   A 1 41  ? -6.01927  -2.71914  3.22910   1.000 41.21239 ? 38  SER   A OG  1 
ATOM   266  N N   . GLU   A 1 54  ? -2.77351  11.61626  -1.06140  1.000 35.89052 ? 51  GLU   A N   1 
ATOM   267  C CA  . GLU   A 1 54  ? -2.36636  12.09313  0.25853   1.000 21.75385 ? 51  GLU   A CA  1 
ATOM   268  C C   . GLU   A 1 54  ? -3.10168  13.38203  0.62102   1.000 23.08464 ? 51  GLU   A C   1 
ATOM   269  O O   . GLU   A 1 54  ? -3.09705  14.33731  -0.15383  1.000 21.48601 ? 51  GLU   A O   1 
ATOM   270  C CB  . GLU   A 1 54  ? -0.85039  12.30361  0.29834   1.000 26.77934 ? 51  GLU   A CB  1 
ATOM   271  C CG  . GLU   A 1 54  ? -0.29648  12.63055  1.66945   1.000 29.76232 ? 51  GLU   A CG  1 
ATOM   272  C CD  . GLU   A 1 54  ? 1.22653   12.70395  1.69961   1.000 23.75306 ? 51  GLU   A CD  1 
ATOM   273  O OE1 . GLU   A 1 54  ? 1.89202   11.64123  1.75332   1.000 29.59251 ? 51  GLU   A OE1 1 
ATOM   274  O OE2 . GLU   A 1 54  ? 1.76179   13.82788  1.68247   1.000 23.79845 ? 51  GLU   A OE2 1 
ATOM   275  N N   . PRO   A 1 55  ? -3.73788  13.41477  1.78987   1.000 17.76624 ? 52  PRO   A N   1 
ATOM   276  C CA  . PRO   A 1 55  ? -4.46456  14.62022  2.19414   1.000 19.59247 ? 52  PRO   A CA  1 
ATOM   277  C C   . PRO   A 1 55  ? -3.50199  15.74813  2.52277   1.000 20.27923 ? 52  PRO   A C   1 
ATOM   278  O O   . PRO   A 1 55  ? -2.32736  15.53194  2.83374   1.000 18.96097 ? 52  PRO   A O   1 
ATOM   279  C CB  . PRO   A 1 55  ? -5.23294  14.16950  3.43821   1.000 18.73908 ? 52  PRO   A CB  1 
ATOM   280  C CG  . PRO   A 1 55  ? -4.35569  13.11780  4.02578   1.000 23.80866 ? 52  PRO   A CG  1 
ATOM   281  C CD  . PRO   A 1 55  ? -3.75963  12.38567  2.84549   1.000 22.66450 ? 52  PRO   A CD  1 
ATOM   282  N N   . ALA   A 1 56  ? -4.02025  16.97559  2.44456   1.000 18.62308 ? 53  ALA   A N   1 
ATOM   283  C CA  . ALA   A 1 56  ? -3.20198  18.12531  2.81971   1.000 17.84665 ? 53  ALA   A CA  1 
ATOM   284  C C   . ALA   A 1 56  ? -2.82236  18.06552  4.29254   1.000 17.22506 ? 53  ALA   A C   1 
ATOM   285  O O   . ALA   A 1 56  ? -1.69491  18.40917  4.66544   1.000 20.08701 ? 53  ALA   A O   1 
ATOM   286  C CB  . ALA   A 1 56  ? -3.93620  19.43016  2.50993   1.000 18.01520 ? 53  ALA   A CB  1 
ATOM   287  N N   . ARG   A 1 57  ? -3.73989  17.61237  5.14597   1.000 18.77482 ? 54  ARG   A N   1 
ATOM   288  C CA  . ARG   A 1 57  ? -3.48412  17.56386  6.57632   1.000 15.78365 ? 54  ARG   A CA  1 
ATOM   289  C C   . ARG   A 1 57  ? -3.93777  16.23032  7.14396   1.000 17.33037 ? 54  ARG   A C   1 
ATOM   290  O O   . ARG   A 1 57  ? -4.87478  15.60524  6.63899   1.000 18.84188 ? 54  ARG   A O   1 
ATOM   291  C CB  . ARG   A 1 57  ? -4.19364  18.70243  7.31246   1.000 18.42316 ? 54  ARG   A CB  1 
ATOM   292  C CG  . ARG   A 1 57  ? -3.87144  20.07951  6.73279   1.000 17.52215 ? 54  ARG   A CG  1 
ATOM   293  C CD  . ARG   A 1 57  ? -3.90339  21.16659  7.79480   1.000 24.92764 ? 54  ARG   A CD  1 
ATOM   294  N NE  . ARG   A 1 57  ? -5.22903  21.39205  8.34963   1.000 25.12793 ? 54  ARG   A NE  1 
ATOM   295  C CZ  . ARG   A 1 57  ? -5.45533  22.15565  9.40982   1.000 31.09169 ? 54  ARG   A CZ  1 
ATOM   296  N NH1 . ARG   A 1 57  ? -4.46280  22.73599  10.06176  1.000 35.78106 ? 54  ARG   A NH1 1 
ATOM   297  N NH2 . ARG   A 1 57  ? -6.70296  22.33238  9.83002   1.000 37.80966 ? 54  ARG   A NH2 1 
ATOM   298  N N   . VAL   A 1 58  ? -3.23844  15.79781  8.19461   1.000 15.86472 ? 55  VAL   A N   1 
ATOM   299  C CA  . VAL   A 1 58  ? -3.67356  14.69445  9.03348   1.000 15.80303 ? 55  VAL   A CA  1 
ATOM   300  C C   . VAL   A 1 58  ? -3.81606  15.21704  10.44925  1.000 15.00453 ? 55  VAL   A C   1 
ATOM   301  O O   . VAL   A 1 58  ? -3.23611  16.24037  10.82419  1.000 15.29237 ? 55  VAL   A O   1 
ATOM   302  C CB  . VAL   A 1 58  ? -2.70609  13.49698  9.00417   1.000 15.79735 ? 55  VAL   A CB  1 
ATOM   303  C CG1 . VAL   A 1 58  ? -2.68379  12.88143  7.62457   1.000 17.27809 ? 55  VAL   A CG1 1 
ATOM   304  C CG2 . VAL   A 1 58  ? -1.28531  13.91177  9.45239   1.000 14.91720 ? 55  VAL   A CG2 1 
ATOM   305  N N   . ARG   A 1 59  ? -4.60218  14.49533  11.24434  1.000 15.00442 ? 56  ARG   A N   1 
ATOM   306  C CA  . ARG   A 1 59  ? -4.73925  14.77216  12.66516  1.000 13.04544 ? 56  ARG   A CA  1 
ATOM   307  C C   . ARG   A 1 59  ? -4.19991  13.57522  13.42624  1.000 14.01496 ? 56  ARG   A C   1 
ATOM   308  O O   . ARG   A 1 59  ? -4.55098  12.43273  13.11398  1.000 12.93316 ? 56  ARG   A O   1 
ATOM   309  C CB  . ARG   A 1 59  ? -6.19597  15.04282  13.05367  1.000 15.08033 ? 56  ARG   A CB  1 
ATOM   310  C CG  . ARG   A 1 59  ? -6.35930  15.49604  14.49356  1.000 14.12668 ? 56  ARG   A CG  1 
ATOM   311  C CD  . ARG   A 1 59  ? -7.83141  15.68079  14.81881  1.000 17.78017 ? 56  ARG   A CD  1 
ATOM   312  N NE  . ARG   A 1 59  ? -8.03303  16.27799  16.13156  1.000 17.79849 ? 56  ARG   A NE  1 
ATOM   313  C CZ  . ARG   A 1 59  ? -9.20518  16.72035  16.56730  1.000 24.79502 ? 56  ARG   A CZ  1 
ATOM   314  N NH1 . ARG   A 1 59  ? -10.29325 16.64781  15.81586  1.000 29.27742 ? 56  ARG   A NH1 1 
ATOM   315  N NH2 . ARG   A 1 59  ? -9.28670  17.25260  17.78142  1.000 25.22275 ? 56  ARG   A NH2 1 
ATOM   316  N N   . CYS   A 1 60  ? -3.32309  13.82933  14.39814  1.000 13.09736 ? 57  CYS   A N   1 
ATOM   317  C CA  . CYS   A 1 60  ? -2.72778  12.74293  15.16139  1.000 12.60535 ? 57  CYS   A CA  1 
ATOM   318  C C   . CYS   A 1 60  ? -2.72474  13.08153  16.63966  1.000 12.37852 ? 57  CYS   A C   1 
ATOM   319  O O   . CYS   A 1 60  ? -2.68097  14.25802  17.02825  1.000 12.99319 ? 57  CYS   A O   1 
ATOM   320  C CB  . CYS   A 1 60  ? -1.28169  12.46337  14.73205  1.000 13.87545 ? 57  CYS   A CB  1 
ATOM   321  S SG  . CYS   A 1 60  ? -1.13790  11.87576  13.07251  1.000 15.32693 ? 57  CYS   A SG  1 
ATOM   322  N N   . SER   A 1 61  ? -2.76916  12.02794  17.45740  1.000 11.75325 ? 58  SER   A N   1 
ATOM   323  C CA  . SER   A 1 61  ? -2.42431  12.09068  18.87153  1.000 11.41048 ? 58  SER   A CA  1 
ATOM   324  C C   . SER   A 1 61  ? -1.06495  11.43252  19.05569  1.000 10.40676 ? 58  SER   A C   1 
ATOM   325  O O   . SER   A 1 61  ? -0.62218  10.66567  18.20046  1.000 13.17488 ? 58  SER   A O   1 
ATOM   326  C CB  . SER   A 1 61  ? -3.46476  11.37746  19.73648  1.000 13.62540 ? 58  SER   A CB  1 
ATOM   327  O OG  . SER   A 1 61  ? -4.75094  11.94875  19.55896  1.000 14.84315 ? 58  SER   A OG  1 
ATOM   328  N N   . HIS   A 1 62  ? -0.38998  11.74773  20.16082  1.000 12.02108 ? 59  HIS   A N   1 
ATOM   329  C CA  . HIS   A 1 62  ? 0.84609   11.02738  20.44389  1.000 11.88215 ? 59  HIS   A CA  1 
ATOM   330  C C   . HIS   A 1 62  ? 1.06444   10.90864  21.94097  1.000 12.33795 ? 59  HIS   A C   1 
ATOM   331  O O   . HIS   A 1 62  ? 0.41634   11.58147  22.75344  1.000 12.93969 ? 59  HIS   A O   1 
ATOM   332  C CB  . HIS   A 1 62  ? 2.07670   11.66268  19.77076  1.000 11.65210 ? 59  HIS   A CB  1 
ATOM   333  C CG  . HIS   A 1 62  ? 2.62965   12.87280  20.47080  1.000 12.28677 ? 59  HIS   A CG  1 
ATOM   334  N ND1 . HIS   A 1 62  ? 3.97338   13.18473  20.44649  1.000 14.24656 ? 59  HIS   A ND1 1 
ATOM   335  C CD2 . HIS   A 1 62  ? 2.02851   13.85833  21.17851  1.000 13.18544 ? 59  HIS   A CD2 1 
ATOM   336  C CE1 . HIS   A 1 62  ? 4.17698   14.29878  21.12702  1.000 13.11405 ? 59  HIS   A CE1 1 
ATOM   337  N NE2 . HIS   A 1 62  ? 3.01042   14.73436  21.57434  1.000 13.42672 ? 59  HIS   A NE2 1 
ATOM   338  N N   . LEU   A 1 63  ? 1.95118   9.97677   22.28279  1.000 11.28658 ? 60  LEU   A N   1 
ATOM   339  C CA  . LEU   A 1 63  ? 2.49612   9.80695   23.62096  1.000 10.78744 ? 60  LEU   A CA  1 
ATOM   340  C C   . LEU   A 1 63  ? 4.00091   9.98043   23.47813  1.000 10.24563 ? 60  LEU   A C   1 
ATOM   341  O O   . LEU   A 1 63  ? 4.62801   9.26448   22.69087  1.000 13.57412 ? 60  LEU   A O   1 
ATOM   342  C CB  . LEU   A 1 63  ? 2.13296   8.42571   24.17398  1.000 11.70716 ? 60  LEU   A CB  1 
ATOM   343  C CG  . LEU   A 1 63  ? 2.44291   8.06889   25.63601  1.000 11.57616 ? 60  LEU   A CG  1 
ATOM   344  C CD1 . LEU   A 1 63  ? 1.76640   6.78188   26.01699  1.000 11.98088 ? 60  LEU   A CD1 1 
ATOM   345  C CD2 . LEU   A 1 63  ? 3.96784   7.96516   25.91761  1.000 13.94730 ? 60  LEU   A CD2 1 
ATOM   346  N N   . LEU   A 1 64  ? 4.56728   10.92861  24.21659  1.000 11.86682 ? 61  LEU   A N   1 
ATOM   347  C CA  . LEU   A 1 64  ? 5.98933   11.25875  24.15700  1.000 12.83782 ? 61  LEU   A CA  1 
ATOM   348  C C   . LEU   A 1 64  ? 6.67659   10.76959  25.42191  1.000 13.02847 ? 61  LEU   A C   1 
ATOM   349  O O   . LEU   A 1 64  ? 6.21573   11.07014  26.53127  1.000 13.64831 ? 61  LEU   A O   1 
ATOM   350  C CB  . LEU   A 1 64  ? 6.17522   12.77529  24.02690  1.000 11.55332 ? 61  LEU   A CB  1 
ATOM   351  C CG  . LEU   A 1 64  ? 7.61327   13.29098  24.15505  1.000 13.35743 ? 61  LEU   A CG  1 
ATOM   352  C CD1 . LEU   A 1 64  ? 8.45603   12.77869  22.98256  1.000 13.18184 ? 61  LEU   A CD1 1 
ATOM   353  C CD2 . LEU   A 1 64  ? 7.63279   14.83163  24.21049  1.000 12.45949 ? 61  LEU   A CD2 1 
ATOM   354  N N   . VAL   A 1 65  ? 7.79468   10.04940  25.26823  1.000 12.02288 ? 62  VAL   A N   1 
ATOM   355  C CA  . VAL   A 1 65  ? 8.64665   9.70635   26.40820  1.000 13.23223 ? 62  VAL   A CA  1 
ATOM   356  C C   . VAL   A 1 65  ? 9.96457   10.43917  26.18777  1.000 14.19322 ? 62  VAL   A C   1 
ATOM   357  O O   . VAL   A 1 65  ? 10.65349  10.20293  25.18713  1.000 13.11158 ? 62  VAL   A O   1 
ATOM   358  C CB  . VAL   A 1 65  ? 8.85339   8.19373   26.57531  1.000 12.25890 ? 62  VAL   A CB  1 
ATOM   359  C CG1 . VAL   A 1 65  ? 9.80275   7.92651   27.72735  1.000 15.09395 ? 62  VAL   A CG1 1 
ATOM   360  C CG2 . VAL   A 1 65  ? 7.52798   7.50180   26.87886  1.000 13.57855 ? 62  VAL   A CG2 1 
ATOM   361  N N   . LYS   A 1 66  ? 10.27721  11.38202  27.06975  1.000 13.86663 ? 63  LYS   A N   1 
ATOM   362  C CA  . LYS   A 1 66  ? 11.51885  12.12827  26.93623  1.000 14.56142 ? 63  LYS   A CA  1 
ATOM   363  C C   . LYS   A 1 66  ? 12.65629  11.35757  27.59638  1.000 15.30077 ? 63  LYS   A C   1 
ATOM   364  O O   . LYS   A 1 66  ? 12.44248  10.36585  28.29021  1.000 14.55533 ? 63  LYS   A O   1 
ATOM   365  C CB  . LYS   A 1 66  ? 11.38640  13.51703  27.56388  1.000 16.64718 ? 63  LYS   A CB  1 
ATOM   366  C CG  . LYS   A 1 66  ? 10.52814  14.47478  26.77941  1.000 14.44997 ? 63  LYS   A CG  1 
ATOM   367  C CD  . LYS   A 1 66  ? 10.50539  15.85399  27.44699  1.000 17.85479 ? 63  LYS   A CD  1 
ATOM   368  C CE  . LYS   A 1 66  ? 9.78673   16.88794  26.58717  1.000 18.06120 ? 63  LYS   A CE  1 
ATOM   369  N NZ  . LYS   A 1 66  ? 9.98187   18.26401  27.16193  1.000 22.78141 ? 63  LYS   A NZ  1 
ATOM   370  N N   . HIS   A 1 67  ? 13.88675  11.81671  27.35862  1.000 16.78698 ? 64  HIS   A N   1 
ATOM   371  C CA  . HIS   A 1 67  ? 15.05851  11.19892  27.96908  1.000 16.05481 ? 64  HIS   A CA  1 
ATOM   372  C C   . HIS   A 1 67  ? 16.08965  12.29419  28.21546  1.000 18.35465 ? 64  HIS   A C   1 
ATOM   373  O O   . HIS   A 1 67  ? 15.85959  13.46160  27.90209  1.000 17.29196 ? 64  HIS   A O   1 
ATOM   374  C CB  . HIS   A 1 67  ? 15.59506  10.05863  27.09828  1.000 18.88224 ? 64  HIS   A CB  1 
ATOM   375  C CG  . HIS   A 1 67  ? 15.84247  10.44894  25.67732  1.000 18.72181 ? 64  HIS   A CG  1 
ATOM   376  N ND1 . HIS   A 1 67  ? 16.94126  11.18632  25.28781  1.000 22.33167 ? 64  HIS   A ND1 1 
ATOM   377  C CD2 . HIS   A 1 67  ? 15.12966  10.21151  24.55065  1.000 18.46693 ? 64  HIS   A CD2 1 
ATOM   378  C CE1 . HIS   A 1 67  ? 16.90004  11.37461  23.98117  1.000 22.98007 ? 64  HIS   A CE1 1 
ATOM   379  N NE2 . HIS   A 1 67  ? 15.81154  10.79312  23.50957  1.000 23.07960 ? 64  HIS   A NE2 1 
ATOM   380  N N   . SER   A 1 68  ? 17.23340  11.91518  28.79607  1.000 20.60597 ? 65  SER   A N   1 
ATOM   381  C CA  . SER   A 1 68  ? 18.19134  12.93304  29.22561  1.000 23.47543 ? 65  SER   A CA  1 
ATOM   382  C C   . SER   A 1 68  ? 18.77944  13.71948  28.06341  1.000 24.84468 ? 65  SER   A C   1 
ATOM   383  O O   . SER   A 1 68  ? 19.27947  14.83126  28.27573  1.000 26.98498 ? 65  SER   A O   1 
ATOM   384  C CB  . SER   A 1 68  ? 19.32403  12.29713  30.02955  1.000 22.09335 ? 65  SER   A CB  1 
ATOM   385  O OG  . SER   A 1 68  ? 20.12981  11.48468  29.20320  1.000 24.51314 ? 65  SER   A OG  1 
ATOM   386  N N   . GLN   A 1 69  ? 18.73587  13.17826  26.85029  1.000 21.63357 ? 66  GLN   A N   1 
ATOM   387  C CA  . GLN   A 1 69  ? 19.24947  13.85775  25.67168  1.000 26.74015 ? 66  GLN   A CA  1 
ATOM   388  C C   . GLN   A 1 69  ? 18.15969  14.57681  24.88265  1.000 21.32325 ? 66  GLN   A C   1 
ATOM   389  O O   . GLN   A 1 69  ? 18.44911  15.14211  23.82426  1.000 23.91451 ? 66  GLN   A O   1 
ATOM   390  C CB  . GLN   A 1 69  ? 19.99194  12.86186  24.77851  1.000 33.57929 ? 66  GLN   A CB  1 
ATOM   391  C CG  . GLN   A 1 69  ? 21.14859  12.15018  25.47979  1.000 37.57605 ? 66  GLN   A CG  1 
ATOM   392  C CD  . GLN   A 1 69  ? 21.03633  10.63391  25.40191  1.000 46.50753 ? 66  GLN   A CD  1 
ATOM   393  O OE1 . GLN   A 1 69  ? 21.53738  10.01377  24.46351  1.000 47.36782 ? 66  GLN   A OE1 1 
ATOM   394  N NE2 . GLN   A 1 69  ? 20.36580  10.03073  26.38665  1.000 42.37902 ? 66  GLN   A NE2 1 
ATOM   395  N N   . SER   A 1 70  ? 16.91968  14.58286  25.37874  1.000 18.08174 ? 67  SER   A N   1 
ATOM   396  C CA  . SER   A 1 70  ? 15.88178  15.40041  24.76862  1.000 18.89977 ? 67  SER   A CA  1 
ATOM   397  C C   . SER   A 1 70  ? 16.30677  16.86303  24.76604  1.000 20.24918 ? 67  SER   A C   1 
ATOM   398  O O   . SER   A 1 70  ? 17.07924  17.30782  25.62249  1.000 23.38883 ? 67  SER   A O   1 
ATOM   399  C CB  . SER   A 1 70  ? 14.56436  15.25377  25.52490  1.000 18.51953 ? 67  SER   A CB  1 
ATOM   400  O OG  . SER   A 1 70  ? 13.99072  13.97393  25.30824  1.000 18.91189 ? 67  SER   A OG  1 
ATOM   401  N N   . ARG   A 1 71  ? 15.79647  17.61807  23.79154  1.000 21.57844 ? 68  ARG   A N   1 
ATOM   402  C CA  . ARG   A 1 71  ? 16.16387  19.03019  23.73711  1.000 23.76641 ? 68  ARG   A CA  1 
ATOM   403  C C   . ARG   A 1 71  ? 15.72329  19.77192  24.99385  1.000 30.31141 ? 68  ARG   A C   1 
ATOM   404  O O   . ARG   A 1 71  ? 16.42639  20.68071  25.44831  1.000 25.90159 ? 68  ARG   A O   1 
ATOM   405  C CB  . ARG   A 1 71  ? 15.60669  19.68984  22.47078  1.000 31.46581 ? 68  ARG   A CB  1 
ATOM   406  C CG  . ARG   A 1 71  ? 14.10703  19.72630  22.34579  1.000 35.23992 ? 68  ARG   A CG  1 
ATOM   407  C CD  . ARG   A 1 71  ? 13.70362  20.40878  21.04364  1.000 40.56625 ? 68  ARG   A CD  1 
ATOM   408  N NE  . ARG   A 1 71  ? 14.10838  21.80927  20.99305  1.000 44.44971 ? 68  ARG   A NE  1 
ATOM   409  C CZ  . ARG   A 1 71  ? 13.34939  22.82242  21.39160  1.000 50.09766 ? 68  ARG   A CZ  1 
ATOM   410  N NH1 . ARG   A 1 71  ? 12.13555  22.62692  21.88176  1.000 43.30792 ? 68  ARG   A NH1 1 
ATOM   411  N NH2 . ARG   A 1 71  ? 13.82022  24.06267  21.29636  1.000 55.31819 ? 68  ARG   A NH2 1 
ATOM   412  N N   . ARG   A 1 72  ? 14.59633  19.37585  25.59442  1.000 23.07842 ? 69  ARG   A N   1 
ATOM   413  C CA  . ARG   A 1 72  ? 14.11345  19.95206  26.85075  1.000 25.51533 ? 69  ARG   A CA  1 
ATOM   414  C C   . ARG   A 1 72  ? 13.79682  18.82559  27.82435  1.000 23.66490 ? 69  ARG   A C   1 
ATOM   415  O O   . ARG   A 1 72  ? 12.65219  18.35627  27.89692  1.000 21.13647 ? 69  ARG   A O   1 
ATOM   416  C CB  . ARG   A 1 72  ? 12.88482  20.83275  26.62850  1.000 25.03991 ? 69  ARG   A CB  1 
ATOM   417  C CG  . ARG   A 1 72  ? 13.19789  22.29738  26.35747  1.000 37.98907 ? 69  ARG   A CG  1 
ATOM   418  C CD  . ARG   A 1 72  ? 13.42007  22.56389  24.88649  1.000 46.43289 ? 69  ARG   A CD  1 
ATOM   419  N NE  . ARG   A 1 72  ? 14.63361  23.34041  24.65026  1.000 58.12840 ? 69  ARG   A NE  1 
ATOM   420  C CZ  . ARG   A 1 72  ? 14.67403  24.65513  24.47406  1.000 61.58623 ? 69  ARG   A CZ  1 
ATOM   421  N NH1 . ARG   A 1 72  ? 13.57652  25.39543  24.51207  1.000 63.88389 ? 69  ARG   A NH1 1 
ATOM   422  N NH2 . ARG   A 1 72  ? 15.84595  25.24203  24.24741  1.000 55.93613 ? 69  ARG   A NH2 1 
ATOM   423  N N   . PRO   A 1 73  ? 14.78022  18.38716  28.61644  1.000 20.94874 ? 70  PRO   A N   1 
ATOM   424  C CA  . PRO   A 1 73  ? 14.60995  17.21715  29.50452  1.000 19.70673 ? 70  PRO   A CA  1 
ATOM   425  C C   . PRO   A 1 73  ? 13.87757  17.54761  30.80561  1.000 22.76536 ? 70  PRO   A C   1 
ATOM   426  O O   . PRO   A 1 73  ? 14.39745  17.38262  31.91460  1.000 23.44090 ? 70  PRO   A O   1 
ATOM   427  C CB  . PRO   A 1 73  ? 16.06172  16.77817  29.73561  1.000 24.11505 ? 70  PRO   A CB  1 
ATOM   428  C CG  . PRO   A 1 73  ? 16.83029  18.06000  29.68210  1.000 24.47888 ? 70  PRO   A CG  1 
ATOM   429  C CD  . PRO   A 1 73  ? 16.16991  18.88543  28.61478  1.000 24.11785 ? 70  PRO   A CD  1 
ATOM   430  N N   . SER   A 1 74  ? 12.63802  18.01086  30.66901  1.000 20.67481 ? 71  SER   A N   1 
ATOM   431  C CA  . SER   A 1 74  ? 11.74566  18.30223  31.78452  1.000 17.77319 ? 71  SER   A CA  1 
ATOM   432  C C   . SER   A 1 74  ? 10.32946  18.27714  31.23420  1.000 20.27938 ? 71  SER   A C   1 
ATOM   433  O O   . SER   A 1 74  ? 10.11988  18.47252  30.03435  1.000 21.39260 ? 71  SER   A O   1 
ATOM   434  C CB  . SER   A 1 74  ? 12.04515  19.66205  32.42636  1.000 22.34097 ? 71  SER   A CB  1 
ATOM   435  O OG  . SER   A 1 74  ? 11.91694  20.69818  31.47091  1.000 28.04537 ? 71  SER   A OG  1 
ATOM   436  N N   . SER   A 1 75  ? 9.35871   18.02440  32.11107  1.000 19.41892 ? 72  SER   A N   1 
ATOM   437  C CA  . SER   A 1 75  ? 7.96623   17.96874  31.67068  1.000 18.66254 ? 72  SER   A CA  1 
ATOM   438  C C   . SER   A 1 75  ? 7.03800   18.28682  32.83707  1.000 21.53626 ? 72  SER   A C   1 
ATOM   439  O O   . SER   A 1 75  ? 7.46441   18.38778  33.99008  1.000 20.86420 ? 72  SER   A O   1 
ATOM   440  C CB  . SER   A 1 75  ? 7.61893   16.59681  31.08634  1.000 17.74811 ? 72  SER   A CB  1 
ATOM   441  O OG  . SER   A 1 75  ? 7.41817   15.66561  32.12672  1.000 18.21648 ? 72  SER   A OG  1 
ATOM   442  N N   . TRP   A 1 76  ? 5.74029   18.40405  32.51912  1.000 21.98446 ? 73  TRP   A N   1 
ATOM   443  C CA  . TRP   A 1 76  ? 4.72753   18.62946  33.54809  1.000 22.97328 ? 73  TRP   A CA  1 
ATOM   444  C C   . TRP   A 1 76  ? 4.71113   17.52772  34.60791  1.000 20.71458 ? 73  TRP   A C   1 
ATOM   445  O O   . TRP   A 1 76  ? 4.24086   17.77021  35.72870  1.000 22.12260 ? 73  TRP   A O   1 
ATOM   446  C CB  . TRP   A 1 76  ? 3.33024   18.73275  32.91524  1.000 18.05128 ? 73  TRP   A CB  1 
ATOM   447  C CG  . TRP   A 1 76  ? 2.90076   17.41506  32.36084  1.000 17.82472 ? 73  TRP   A CG  1 
ATOM   448  C CD1 . TRP   A 1 76  ? 3.26378   16.88505  31.15327  1.000 20.96793 ? 73  TRP   A CD1 1 
ATOM   449  C CD2 . TRP   A 1 76  ? 2.09857   16.42299  33.00993  1.000 17.74942 ? 73  TRP   A CD2 1 
ATOM   450  N NE1 . TRP   A 1 76  ? 2.71921   15.63876  31.00535  1.000 18.05235 ? 73  TRP   A NE1 1 
ATOM   451  C CE2 . TRP   A 1 76  ? 1.99219   15.32716  32.12383  1.000 18.68175 ? 73  TRP   A CE2 1 
ATOM   452  C CE3 . TRP   A 1 76  ? 1.44362   16.35694  34.24552  1.000 22.49365 ? 73  TRP   A CE3 1 
ATOM   453  C CZ2 . TRP   A 1 76  ? 1.26989   14.18257  32.43564  1.000 20.06983 ? 73  TRP   A CZ2 1 
ATOM   454  C CZ3 . TRP   A 1 76  ? 0.72161   15.21803  34.55446  1.000 23.85214 ? 73  TRP   A CZ3 1 
ATOM   455  C CH2 . TRP   A 1 76  ? 0.63752   14.14362  33.65294  1.000 24.22959 ? 73  TRP   A CH2 1 
ATOM   456  N N   . ARG   A 1 77  ? 5.20922   16.32440  34.29125  1.000 18.58775 ? 74  ARG   A N   1 
ATOM   457  C CA  . ARG   A 1 77  ? 5.12683   15.19347  35.20657  1.000 20.96320 ? 74  ARG   A CA  1 
ATOM   458  C C   . ARG   A 1 77  ? 6.46433   14.83660  35.83404  1.000 22.03592 ? 74  ARG   A C   1 
ATOM   459  O O   . ARG   A 1 77  ? 6.50450   13.95630  36.69989  1.000 21.47522 ? 74  ARG   A O   1 
ATOM   460  C CB  . ARG   A 1 77  ? 4.53652   13.96029  34.50158  1.000 21.28904 ? 74  ARG   A CB  1 
ATOM   461  C CG  . ARG   A 1 77  ? 5.41944   13.36583  33.40861  1.000 21.32483 ? 74  ARG   A CG  1 
ATOM   462  C CD  . ARG   A 1 77  ? 4.74780   12.17179  32.72149  1.000 20.55894 ? 74  ARG   A CD  1 
ATOM   463  N NE  . ARG   A 1 77  ? 4.36927   11.14672  33.68567  1.000 21.22057 ? 74  ARG   A NE  1 
ATOM   464  C CZ  . ARG   A 1 77  ? 5.17578   10.18577  34.11417  1.000 19.66708 ? 74  ARG   A CZ  1 
ATOM   465  N NH1 . ARG   A 1 77  ? 6.37867   10.00741  33.59241  1.000 26.81890 ? 74  ARG   A NH1 1 
ATOM   466  N NH2 . ARG   A 1 77  ? 4.76515   9.38252   35.08873  1.000 23.81739 ? 74  ARG   A NH2 1 
ATOM   467  N N   . GLN   A 1 78  ? 7.55131   15.50436  35.44470  1.000 18.58998 ? 75  GLN   A N   1 
ATOM   468  C CA  . GLN   A 1 78  ? 8.85939   15.21520  36.04031  1.000 20.58846 ? 75  GLN   A CA  1 
ATOM   469  C C   . GLN   A 1 78  ? 9.75679   16.42881  35.85018  1.000 22.54741 ? 75  GLN   A C   1 
ATOM   470  O O   . GLN   A 1 78  ? 10.04299  16.81466  34.71500  1.000 18.90411 ? 75  GLN   A O   1 
ATOM   471  C CB  . GLN   A 1 78  ? 9.48497   13.95559  35.41830  1.000 17.34921 ? 75  GLN   A CB  1 
ATOM   472  C CG  . GLN   A 1 78  ? 10.91412  13.68696  35.90635  1.000 21.40708 ? 75  GLN   A CG  1 
ATOM   473  C CD  . GLN   A 1 78  ? 11.41288  12.29263  35.57456  1.000 20.83423 ? 75  GLN   A CD  1 
ATOM   474  O OE1 . GLN   A 1 78  ? 11.20881  11.79827  34.47052  1.000 21.65837 ? 75  GLN   A OE1 1 
ATOM   475  N NE2 . GLN   A 1 78  ? 12.08053  11.64789  36.53955  1.000 19.50745 ? 75  GLN   A NE2 1 
ATOM   476  N N   . GLU   A 1 79  ? 10.21028  17.02252  36.95816  1.000 21.19175 ? 76  GLU   A N   1 
ATOM   477  C CA  . GLU   A 1 79  ? 10.96847  18.26540  36.87750  1.000 20.62220 ? 76  GLU   A CA  1 
ATOM   478  C C   . GLU   A 1 79  ? 12.28806  18.07082  36.14481  1.000 19.65352 ? 76  GLU   A C   1 
ATOM   479  O O   . GLU   A 1 79  ? 12.69583  18.92718  35.34817  1.000 22.85567 ? 76  GLU   A O   1 
ATOM   480  C CB  . GLU   A 1 79  ? 11.22659  18.81903  38.28197  1.000 21.88038 ? 76  GLU   A CB  1 
ATOM   481  C CG  . GLU   A 1 79  ? 9.97062   19.18368  39.04818  1.000 26.05142 ? 76  GLU   A CG  1 
ATOM   482  C CD  . GLU   A 1 79  ? 10.25757  19.83696  40.38456  1.000 29.33274 ? 76  GLU   A CD  1 
ATOM   483  O OE1 . GLU   A 1 79  ? 11.42841  19.82242  40.82885  1.000 28.26704 ? 76  GLU   A OE1 1 
ATOM   484  O OE2 . GLU   A 1 79  ? 9.30645   20.38138  40.97988  1.000 37.10298 ? 76  GLU   A OE2 1 
ATOM   485  N N   . LYS   A 1 80  ? 12.98314  16.96976  36.42388  1.000 19.65315 ? 77  LYS   A N   1 
ATOM   486  C CA  . LYS   A 1 80  ? 14.29992  16.68999  35.85558  1.000 24.62453 ? 77  LYS   A CA  1 
ATOM   487  C C   . LYS   A 1 80  ? 14.28779  15.28424  35.26980  1.000 20.07534 ? 77  LYS   A C   1 
ATOM   488  O O   . LYS   A 1 80  ? 14.27632  14.29702  36.01208  1.000 21.85216 ? 77  LYS   A O   1 
ATOM   489  C CB  . LYS   A 1 80  ? 15.38640  16.82858  36.92398  1.000 28.08240 ? 77  LYS   A CB  1 
ATOM   490  C CG  . LYS   A 1 80  ? 16.77506  16.42013  36.48856  1.000 32.84317 ? 77  LYS   A CG  1 
ATOM   491  C CD  . LYS   A 1 80  ? 17.67966  16.24493  37.70205  1.000 39.46347 ? 77  LYS   A CD  1 
ATOM   492  C CE  . LYS   A 1 80  ? 19.11647  15.99448  37.28970  1.000 46.61741 ? 77  LYS   A CE  1 
ATOM   493  N NZ  . LYS   A 1 80  ? 19.68736  17.18148  36.60282  1.000 50.49178 ? 77  LYS   A NZ  1 
ATOM   494  N N   . ILE   A 1 81  ? 14.28389  15.18584  33.94348  1.000 18.58573 ? 78  ILE   A N   1 
ATOM   495  C CA  . ILE   A 1 81  ? 14.20065  13.89138  33.27313  1.000 17.58546 ? 78  ILE   A CA  1 
ATOM   496  C C   . ILE   A 1 81  ? 15.60632  13.33660  33.08572  1.000 21.37033 ? 78  ILE   A C   1 
ATOM   497  O O   . ILE   A 1 81  ? 16.44312  13.94070  32.40399  1.000 22.65677 ? 78  ILE   A O   1 
ATOM   498  C CB  . ILE   A 1 81  ? 13.44526  14.00829  31.94272  1.000 20.70208 ? 78  ILE   A CB  1 
ATOM   499  C CG1 . ILE   A 1 81  ? 12.01378  14.45898  32.24532  1.000 20.68446 ? 78  ILE   A CG1 1 
ATOM   500  C CG2 . ILE   A 1 81  ? 13.43191  12.66879  31.19847  1.000 20.96240 ? 78  ILE   A CG2 1 
ATOM   501  C CD1 . ILE   A 1 81  ? 11.13281  14.61276  31.03226  1.000 21.05357 ? 78  ILE   A CD1 1 
ATOM   502  N N   . THR   A 1 82  ? 15.85967  12.18097  33.70007  1.000 20.56031 ? 79  THR   A N   1 
ATOM   503  C CA  . THR   A 1 82  ? 17.18633  11.59415  33.75111  1.000 22.31823 ? 79  THR   A CA  1 
ATOM   504  C C   . THR   A 1 82  ? 17.30681  10.26731  33.01836  1.000 22.82603 ? 79  THR   A C   1 
ATOM   505  O O   . THR   A 1 82  ? 18.43284  9.78879   32.83972  1.000 22.96984 ? 79  THR   A O   1 
ATOM   506  C CB  . THR   A 1 82  ? 17.61809  11.39012  35.21517  1.000 24.91100 ? 79  THR   A CB  1 
ATOM   507  O OG1 . THR   A 1 82  ? 16.69284  10.51159  35.86694  1.000 25.48091 ? 79  THR   A OG1 1 
ATOM   508  C CG2 . THR   A 1 82  ? 17.63998  12.71971  35.94615  1.000 27.69827 ? 79  THR   A CG2 1 
ATOM   509  N N   . ARG   A 1 83  ? 16.20137  9.66146   32.58017  1.000 19.22951 ? 80  ARG   A N   1 
ATOM   510  C CA  . ARG   A 1 83  ? 16.29328  8.34365   31.96348  1.000 18.26380 ? 80  ARG   A CA  1 
ATOM   511  C C   . ARG   A 1 83  ? 17.10109  8.39907   30.66873  1.000 17.63796 ? 80  ARG   A C   1 
ATOM   512  O O   . ARG   A 1 83  ? 17.17377  9.42586   29.98891  1.000 19.82438 ? 80  ARG   A O   1 
ATOM   513  C CB  . ARG   A 1 83  ? 14.89711  7.76799   31.69681  1.000 19.07583 ? 80  ARG   A CB  1 
ATOM   514  C CG  . ARG   A 1 83  ? 14.10734  8.47138   30.60751  1.000 19.03774 ? 80  ARG   A CG  1 
ATOM   515  C CD  . ARG   A 1 83  ? 12.74544  7.78416   30.35223  1.000 16.66642 ? 80  ARG   A CD  1 
ATOM   516  N NE  . ARG   A 1 83  ? 11.81848  7.93151   31.47580  1.000 19.50599 ? 80  ARG   A NE  1 
ATOM   517  C CZ  . ARG   A 1 83  ? 10.95565  8.93486   31.62873  1.000 17.33330 ? 80  ARG   A CZ  1 
ATOM   518  N NH1 . ARG   A 1 83  ? 10.85199  9.90625   30.73998  1.000 15.76553 ? 80  ARG   A NH1 1 
ATOM   519  N NH2 . ARG   A 1 83  ? 10.16420  8.95451   32.69729  1.000 18.50111 ? 80  ARG   A NH2 1 
ATOM   520  N N   . THR   A 1 84  ? 17.74000  7.27880   30.34804  1.000 20.68073 ? 81  THR   A N   1 
ATOM   521  C CA  . THR   A 1 84  ? 18.50055  7.17588   29.11655  1.000 21.80755 ? 81  THR   A CA  1 
ATOM   522  C C   . THR   A 1 84  ? 17.56204  6.98162   27.93020  1.000 18.50453 ? 81  THR   A C   1 
ATOM   523  O O   . THR   A 1 84  ? 16.39064  6.61461   28.08157  1.000 20.85342 ? 81  THR   A O   1 
ATOM   524  C CB  . THR   A 1 84  ? 19.48944  6.00585   29.17551  1.000 24.28220 ? 81  THR   A CB  1 
ATOM   525  O OG1 . THR   A 1 84  ? 18.77113  4.76630   29.16462  1.000 22.83877 ? 81  THR   A OG1 1 
ATOM   526  C CG2 . THR   A 1 84  ? 20.32361  6.06538   30.44143  1.000 21.78709 ? 81  THR   A CG2 1 
ATOM   527  N N   . LYS   A 1 85  ? 18.09948  7.22876   26.73145  1.000 19.23558 ? 82  LYS   A N   1 
ATOM   528  C CA  . LYS   A 1 85  ? 17.33628  6.98004   25.51175  1.000 16.79155 ? 82  LYS   A CA  1 
ATOM   529  C C   . LYS   A 1 85  ? 16.91228  5.51992   25.42676  1.000 21.81014 ? 82  LYS   A C   1 
ATOM   530  O O   . LYS   A 1 85  ? 15.77587  5.20807   25.04184  1.000 19.11347 ? 82  LYS   A O   1 
ATOM   531  C CB  . LYS   A 1 85  ? 18.17139  7.39050   24.29599  1.000 24.84825 ? 82  LYS   A CB  1 
ATOM   532  C CG  . LYS   A 1 85  ? 17.45067  7.32853   22.95432  1.000 29.90348 ? 82  LYS   A CG  1 
ATOM   533  C CD  . LYS   A 1 85  ? 18.38650  7.78305   21.82950  1.000 30.51910 ? 82  LYS   A CD  1 
ATOM   534  C CE  . LYS   A 1 85  ? 17.70440  7.74361   20.47202  1.000 38.47857 ? 82  LYS   A CE  1 
ATOM   535  N NZ  . LYS   A 1 85  ? 18.60310  8.17035   19.35059  1.000 39.34834 ? 82  LYS   A NZ  1 
ATOM   536  N N   . GLU   A 1 86  ? 17.80261  4.61325   25.83484  1.000 21.11521 ? 83  GLU   A N   1 
ATOM   537  C CA  . GLU   A 1 86  ? 17.49126  3.19083   25.86790  1.000 20.46796 ? 83  GLU   A CA  1 
ATOM   538  C C   . GLU   A 1 86  ? 16.33681  2.89563   26.82358  1.000 18.37131 ? 83  GLU   A C   1 
ATOM   539  O O   . GLU   A 1 86  ? 15.45782  2.08283   26.51553  1.000 18.61624 ? 83  GLU   A O   1 
ATOM   540  C CB  . GLU   A 1 86  ? 18.75634  2.41760   26.26944  1.000 22.56960 ? 83  GLU   A CB  1 
ATOM   541  C CG  . GLU   A 1 86  ? 19.93324  2.52807   25.26575  1.000 37.15322 ? 83  GLU   A CG  1 
ATOM   542  C CD  . GLU   A 1 86  ? 20.56975  3.92903   25.13484  1.000 39.90053 ? 83  GLU   A CD  1 
ATOM   543  O OE1 . GLU   A 1 86  ? 20.64555  4.69149   26.12788  1.000 30.89017 ? 83  GLU   A OE1 1 
ATOM   544  O OE2 . GLU   A 1 86  ? 21.00728  4.26900   24.01096  1.000 46.97610 ? 83  GLU   A OE2 1 
ATOM   545  N N   . GLU   A 1 87  ? 16.33035  3.54222   27.99406  1.000 20.06404 ? 84  GLU   A N   1 
ATOM   546  C CA  . GLU   A 1 87  ? 15.25064  3.33856   28.95262  1.000 16.60449 ? 84  GLU   A CA  1 
ATOM   547  C C   . GLU   A 1 87  ? 13.94076  3.91131   28.43136  1.000 15.82832 ? 84  GLU   A C   1 
ATOM   548  O O   . GLU   A 1 87  ? 12.87229  3.32151   28.64529  1.000 18.29389 ? 84  GLU   A O   1 
ATOM   549  C CB  . GLU   A 1 87  ? 15.61435  3.96166   30.29567  1.000 23.08626 ? 84  GLU   A CB  1 
ATOM   550  C CG  . GLU   A 1 87  ? 16.61387  3.12826   31.09139  1.000 23.06134 ? 84  GLU   A CG  1 
ATOM   551  C CD  . GLU   A 1 87  ? 17.23954  3.88801   32.25342  1.000 24.64241 ? 84  GLU   A CD  1 
ATOM   552  O OE1 . GLU   A 1 87  ? 17.22699  5.13814   32.25874  1.000 24.34859 ? 84  GLU   A OE1 1 
ATOM   553  O OE2 . GLU   A 1 87  ? 17.75576  3.21841   33.17367  1.000 32.53188 ? 84  GLU   A OE2 1 
ATOM   554  N N   . ALA   A 1 88  ? 14.00602  5.05470   27.74455  1.000 16.13945 ? 85  ALA   A N   1 
ATOM   555  C CA  . ALA   A 1 88  ? 12.80138  5.61533   27.13729  1.000 16.48634 ? 85  ALA   A CA  1 
ATOM   556  C C   . ALA   A 1 88  ? 12.24051  4.67711   26.08303  1.000 16.72972 ? 85  ALA   A C   1 
ATOM   557  O O   . ALA   A 1 88  ? 11.01828  4.50426   25.97860  1.000 15.28377 ? 85  ALA   A O   1 
ATOM   558  C CB  . ALA   A 1 88  ? 13.10092  6.98646   26.52806  1.000 15.12705 ? 85  ALA   A CB  1 
ATOM   559  N N   . LEU   A 1 89  ? 13.11660  4.06178   25.28792  1.000 16.32181 ? 86  LEU   A N   1 
ATOM   560  C CA  . LEU   A 1 89  ? 12.65183  3.13853   24.25946  1.000 14.69001 ? 86  LEU   A CA  1 
ATOM   561  C C   . LEU   A 1 89  ? 11.97398  1.92144   24.87726  1.000 14.93584 ? 86  LEU   A C   1 
ATOM   562  O O   . LEU   A 1 89  ? 10.96072  1.43678   24.36427  1.000 16.55960 ? 86  LEU   A O   1 
ATOM   563  C CB  . LEU   A 1 89  ? 13.82704  2.71076   23.37403  1.000 15.53538 ? 86  LEU   A CB  1 
ATOM   564  C CG  . LEU   A 1 89  ? 13.47688  1.70944   22.26711  1.000 13.92383 ? 86  LEU   A CG  1 
ATOM   565  C CD1 . LEU   A 1 89  ? 12.39014  2.23586   21.34368  1.000 16.19994 ? 86  LEU   A CD1 1 
ATOM   566  C CD2 . LEU   A 1 89  ? 14.74225  1.40135   21.47623  1.000 16.61066 ? 86  LEU   A CD2 1 
ATOM   567  N N   . GLU   A 1 90  ? 12.51404  1.42158   25.99124  1.000 16.40781 ? 87  GLU   A N   1 
ATOM   568  C CA  . GLU   A 1 90  ? 11.88610  0.29799   26.67956  1.000 17.37656 ? 87  GLU   A CA  1 
ATOM   569  C C   . GLU   A 1 90  ? 10.49596  0.66100   27.18790  1.000 16.30117 ? 87  GLU   A C   1 
ATOM   570  O O   . GLU   A 1 90  ? 9.55620   -0.13640  27.05905  1.000 16.72405 ? 87  GLU   A O   1 
ATOM   571  C CB  . GLU   A 1 90  ? 12.77867  -0.15716  27.83415  1.000 22.28251 ? 87  GLU   A CB  1 
ATOM   572  C CG  . GLU   A 1 90  ? 12.27407  -1.35939  28.59111  1.000 28.31391 ? 87  GLU   A CG  1 
ATOM   573  C CD  . GLU   A 1 90  ? 13.15684  -1.70480  29.77643  1.000 46.99683 ? 87  GLU   A CD  1 
ATOM   574  O OE1 . GLU   A 1 90  ? 13.98812  -0.85524  30.17192  1.000 45.40232 ? 87  GLU   A OE1 1 
ATOM   575  O OE2 . GLU   A 1 90  ? 13.01879  -2.82566  30.31289  1.000 50.56200 ? 87  GLU   A OE2 1 
ATOM   576  N N   . LEU   A 1 91  ? 10.34818  1.86037   27.76592  1.000 15.06155 ? 88  LEU   A N   1 
ATOM   577  C CA  . LEU   A 1 91  ? 9.02794   2.32361   28.19512  1.000 14.76007 ? 88  LEU   A CA  1 
ATOM   578  C C   . LEU   A 1 91  ? 8.06110   2.39773   27.01938  1.000 13.68874 ? 88  LEU   A C   1 
ATOM   579  O O   . LEU   A 1 91  ? 6.92195   1.93480   27.11131  1.000 13.47857 ? 88  LEU   A O   1 
ATOM   580  C CB  . LEU   A 1 91  ? 9.14631   3.69013   28.87672  1.000 14.43617 ? 88  LEU   A CB  1 
ATOM   581  C CG  . LEU   A 1 91  ? 9.73750   3.65495   30.28503  1.000 17.69702 ? 88  LEU   A CG  1 
ATOM   582  C CD1 . LEU   A 1 91  ? 10.22946  5.02537   30.72629  1.000 21.18315 ? 88  LEU   A CD1 1 
ATOM   583  C CD2 . LEU   A 1 91  ? 8.66782   3.12782   31.22951  1.000 18.47334 ? 88  LEU   A CD2 1 
ATOM   584  N N   . ILE   A 1 92  ? 8.50517   2.97742   25.90113  1.000 14.34289 ? 89  ILE   A N   1 
ATOM   585  C CA  . ILE   A 1 92  ? 7.65487   3.09568   24.71259  1.000 13.24561 ? 89  ILE   A CA  1 
ATOM   586  C C   . ILE   A 1 92  ? 7.20153   1.72088   24.23394  1.000 12.90589 ? 89  ILE   A C   1 
ATOM   587  O O   . ILE   A 1 92  ? 6.01853   1.49845   23.94882  1.000 13.51355 ? 89  ILE   A O   1 
ATOM   588  C CB  . ILE   A 1 92  ? 8.41075   3.86186   23.60806  1.000 12.58144 ? 89  ILE   A CB  1 
ATOM   589  C CG1 . ILE   A 1 92  ? 8.43776   5.36846   23.90775  1.000 14.25003 ? 89  ILE   A CG1 1 
ATOM   590  C CG2 . ILE   A 1 92  ? 7.81484   3.59360   22.22507  1.000 13.22814 ? 89  ILE   A CG2 1 
ATOM   591  C CD1 . ILE   A 1 92  ? 7.11674   6.08201   23.59386  1.000 13.21255 ? 89  ILE   A CD1 1 
ATOM   592  N N   . ASN   A 1 93  ? 8.13879   0.77763   24.11704  1.000 13.59390 ? 90  ASN   A N   1 
ATOM   593  C CA  . ASN   A 1 93  ? 7.76583   -0.55696  23.65452  1.000 14.51530 ? 90  ASN   A CA  1 
ATOM   594  C C   . ASN   A 1 93  ? 6.79816   -1.22462  24.62466  1.000 12.86587 ? 90  ASN   A C   1 
ATOM   595  O O   . ASN   A 1 93  ? 5.86604   -1.92113  24.20020  1.000 14.20232 ? 90  ASN   A O   1 
ATOM   596  C CB  . ASN   A 1 93  ? 9.02146   -1.40028  23.44559  1.000 16.45468 ? 90  ASN   A CB  1 
ATOM   597  C CG  . ASN   A 1 93  ? 9.72429   -1.05554  22.16788  1.000 18.82984 ? 90  ASN   A CG  1 
ATOM   598  O OD1 . ASN   A 1 93  ? 9.08332   -0.71224  21.17016  1.000 22.38153 ? 90  ASN   A OD1 1 
ATOM   599  N ND2 . ASN   A 1 93  ? 11.04491  -1.15074  22.17532  1.000 23.32232 ? 90  ASN   A ND2 1 
ATOM   600  N N   . GLY   A 1 94  ? 6.97152   -0.98019  25.92432  1.000 13.25809 ? 91  GLY   A N   1 
ATOM   601  C CA  . GLY   A 1 94  ? 6.02869   -1.50291  26.90342  1.000 14.60151 ? 91  GLY   A CA  1 
ATOM   602  C C   . GLY   A 1 94  ? 4.63830   -0.91207  26.76341  1.000 14.60191 ? 91  GLY   A C   1 
ATOM   603  O O   . GLY   A 1 94  ? 3.63413   -1.62352  26.88757  1.000 15.95140 ? 91  GLY   A O   1 
ATOM   604  N N   . TYR   A 1 95  ? 4.55432   0.39343   26.48230  1.000 13.37960 ? 92  TYR   A N   1 
ATOM   605  C CA  . TYR   A 1 95  ? 3.24412   1.00223   26.28954  1.000 14.56329 ? 92  TYR   A CA  1 
ATOM   606  C C   . TYR   A 1 95  ? 2.56658   0.45504   25.03462  1.000 12.82805 ? 92  TYR   A C   1 
ATOM   607  O O   . TYR   A 1 95  ? 1.35269   0.20770   25.02970  1.000 13.18907 ? 92  TYR   A O   1 
ATOM   608  C CB  . TYR   A 1 95  ? 3.37758   2.53432   26.21044  1.000 11.41304 ? 92  TYR   A CB  1 
ATOM   609  C CG  . TYR   A 1 95  ? 3.88366   3.22790   27.46220  1.000 11.55252 ? 92  TYR   A CG  1 
ATOM   610  C CD1 . TYR   A 1 95  ? 3.53671   2.76721   28.72746  1.000 13.01279 ? 92  TYR   A CD1 1 
ATOM   611  C CD2 . TYR   A 1 95  ? 4.70770   4.34916   27.38119  1.000 13.17016 ? 92  TYR   A CD2 1 
ATOM   612  C CE1 . TYR   A 1 95  ? 3.99989   3.39603   29.87569  1.000 13.58186 ? 92  TYR   A CE1 1 
ATOM   613  C CE2 . TYR   A 1 95  ? 5.19055   4.97438   28.52696  1.000 15.21237 ? 92  TYR   A CE2 1 
ATOM   614  C CZ  . TYR   A 1 95  ? 4.82765   4.49093   29.77247  1.000 14.03417 ? 92  TYR   A CZ  1 
ATOM   615  O OH  . TYR   A 1 95  ? 5.28821   5.10429   30.91664  1.000 17.05789 ? 92  TYR   A OH  1 
ATOM   616  N N   . ILE   A 1 96  ? 3.33380   0.27013   23.95345  1.000 11.31245 ? 93  ILE   A N   1 
ATOM   617  C CA  . ILE   A 1 96  ? 2.77747   -0.34135  22.74774  1.000 11.99056 ? 93  ILE   A CA  1 
ATOM   618  C C   . ILE   A 1 96  ? 2.19945   -1.71384  23.07142  1.000 12.92722 ? 93  ILE   A C   1 
ATOM   619  O O   . ILE   A 1 96  ? 1.09031   -2.05045  22.64085  1.000 13.92209 ? 93  ILE   A O   1 
ATOM   620  C CB  . ILE   A 1 96  ? 3.84929   -0.41890  21.64818  1.000 13.32089 ? 93  ILE   A CB  1 
ATOM   621  C CG1 . ILE   A 1 96  ? 4.14492   0.98946   21.13502  1.000 13.00834 ? 93  ILE   A CG1 1 
ATOM   622  C CG2 . ILE   A 1 96  ? 3.37205   -1.30551  20.48890  1.000 15.92849 ? 93  ILE   A CG2 1 
ATOM   623  C CD1 . ILE   A 1 96  ? 5.37454   1.05534   20.22867  1.000 14.76416 ? 93  ILE   A CD1 1 
ATOM   624  N N   . GLN   A 1 97  ? 2.93409   -2.50793  23.85168  1.000 14.44190 ? 94  GLN   A N   1 
ATOM   625  C CA  . GLN   A 1 97  ? 2.46987   -3.84688  24.20986  1.000 16.51864 ? 94  GLN   A CA  1 
ATOM   626  C C   . GLN   A 1 97  ? 1.16547   -3.78484  25.00331  1.000 15.78885 ? 94  GLN   A C   1 
ATOM   627  O O   . GLN   A 1 97  ? 0.24588   -4.57112  24.75089  1.000 15.73197 ? 94  GLN   A O   1 
ATOM   628  C CB  . GLN   A 1 97  ? 3.57833   -4.57523  24.98048  1.000 15.68580 ? 94  GLN   A CB  1 
ATOM   629  C CG  . GLN   A 1 97  ? 3.37110   -6.08223  25.14863  1.000 15.90940 ? 94  GLN   A CG  1 
ATOM   630  C CD  . GLN   A 1 97  ? 2.42142   -6.43094  26.26325  1.000 21.10837 ? 94  GLN   A CD  1 
ATOM   631  O OE1 . GLN   A 1 97  ? 2.22193   -5.66151  27.21591  1.000 19.79033 ? 94  GLN   A OE1 1 
ATOM   632  N NE2 . GLN   A 1 97  ? 1.80772   -7.59842  26.14813  1.000 21.48016 ? 94  GLN   A NE2 1 
ATOM   633  N N   . LYS   A 1 98  ? 1.05503   -2.83498  25.94538  1.000 13.54090 ? 95  LYS   A N   1 
ATOM   634  C CA  . LYS   A 1 98  ? -0.16814  -2.71785  26.73497  1.000 14.05987 ? 95  LYS   A CA  1 
ATOM   635  C C   . LYS   A 1 98  ? -1.35711  -2.25147  25.89711  1.000 15.03334 ? 95  LYS   A C   1 
ATOM   636  O O   . LYS   A 1 98  ? -2.50355  -2.65063  26.15583  1.000 14.98033 ? 95  LYS   A O   1 
ATOM   637  C CB  . LYS   A 1 98  ? 0.07517   -1.77829  27.91022  1.000 17.44076 ? 95  LYS   A CB  1 
ATOM   638  C CG  . LYS   A 1 98  ? 0.95469   -2.38877  28.98123  1.000 22.17008 ? 95  LYS   A CG  1 
ATOM   639  C CD  . LYS   A 1 98  ? 1.12371   -1.44704  30.15587  1.000 27.87889 ? 95  LYS   A CD  1 
ATOM   640  C CE  . LYS   A 1 98  ? 1.81297   -2.15096  31.30957  1.000 30.21904 ? 95  LYS   A CE  1 
ATOM   641  N NZ  . LYS   A 1 98  ? 1.94368   -1.24241  32.47634  1.000 34.66299 ? 95  LYS   A NZ  1 
ATOM   642  N N   . ILE   A 1 99  ? -1.11570  -1.40503  24.89465  1.000 11.55503 ? 96  ILE   A N   1 
ATOM   643  C CA  . ILE   A 1 99  ? -2.19869  -0.96457  24.02726  1.000 13.06257 ? 96  ILE   A CA  1 
ATOM   644  C C   . ILE   A 1 99  ? -2.68441  -2.12458  23.17087  1.000 14.28840 ? 96  ILE   A C   1 
ATOM   645  O O   . ILE   A 1 99  ? -3.89289  -2.35828  23.04618  1.000 15.49202 ? 96  ILE   A O   1 
ATOM   646  C CB  . ILE   A 1 99  ? -1.73213  0.22831   23.17386  1.000 12.54154 ? 96  ILE   A CB  1 
ATOM   647  C CG1 . ILE   A 1 99  ? -1.41455  1.40310   24.10347  1.000 14.13532 ? 96  ILE   A CG1 1 
ATOM   648  C CG2 . ILE   A 1 99  ? -2.79127  0.60978   22.14195  1.000 15.17771 ? 96  ILE   A CG2 1 
ATOM   649  C CD1 . ILE   A 1 99  ? -0.63007  2.53799   23.42870  1.000 12.92899 ? 96  ILE   A CD1 1 
ATOM   650  N N   . LYS   A 1 100 ? -1.74408  -2.87377  22.58252  1.000 14.75958 ? 97  LYS   A N   1 
ATOM   651  C CA  . LYS   A 1 100 ? -2.11116  -3.98843  21.71238  1.000 13.18244 ? 97  LYS   A CA  1 
ATOM   652  C C   . LYS   A 1 100 ? -2.79009  -5.11215  22.48212  1.000 14.82825 ? 97  LYS   A C   1 
ATOM   653  O O   . LYS   A 1 100 ? -3.70797  -5.75730  21.95664  1.000 19.09584 ? 97  LYS   A O   1 
ATOM   654  C CB  . LYS   A 1 100 ? -0.87378  -4.52779  20.99436  1.000 16.25745 ? 97  LYS   A CB  1 
ATOM   655  C CG  . LYS   A 1 100 ? -0.36798  -3.59962  19.92738  1.000 17.50320 ? 97  LYS   A CG  1 
ATOM   656  C CD  . LYS   A 1 100 ? 0.78772   -4.22522  19.18434  1.000 18.14636 ? 97  LYS   A CD  1 
ATOM   657  C CE  . LYS   A 1 100 ? 1.06839   -3.40829  17.95186  1.000 22.31347 ? 97  LYS   A CE  1 
ATOM   658  N NZ  . LYS   A 1 100 ? 1.67675   -4.22379  16.84743  1.000 25.35070 ? 97  LYS   A NZ  1 
ATOM   659  N N   . SER   A 1 101 ? -2.39447  -5.33770  23.72185  1.000 14.71769 ? 98  SER   A N   1 
ATOM   660  C CA  . SER   A 1 101 ? -3.01433  -6.40845  24.49612  1.000 16.82795 ? 98  SER   A CA  1 
ATOM   661  C C   . SER   A 1 101 ? -4.36695  -6.02036  25.06858  1.000 19.48036 ? 98  SER   A C   1 
ATOM   662  O O   . SER   A 1 101 ? -5.10875  -6.90016  25.52376  1.000 17.50214 ? 98  SER   A O   1 
ATOM   663  C CB  . SER   A 1 101 ? -2.10606  -6.83252  25.64163  1.000 16.16322 ? 98  SER   A CB  1 
ATOM   664  O OG  . SER   A 1 101 ? -2.09147  -5.85676  26.66638  1.000 17.24453 ? 98  SER   A OG  1 
ATOM   665  N N   . GLY   A 1 102 ? -4.69133  -4.73482  25.09778  1.000 16.98438 ? 99  GLY   A N   1 
ATOM   666  C CA  . GLY   A 1 102 ? -5.89104  -4.27562  25.76646  1.000 15.95549 ? 99  GLY   A CA  1 
ATOM   667  C C   . GLY   A 1 102 ? -5.74400  -4.02889  27.24960  1.000 15.17084 ? 99  GLY   A C   1 
ATOM   668  O O   . GLY   A 1 102 ? -6.75572  -3.75688  27.91460  1.000 18.79486 ? 99  GLY   A O   1 
ATOM   669  N N   . GLU   A 1 103 ? -4.53083  -4.12813  27.79415  1.000 15.00180 ? 100 GLU   A N   1 
ATOM   670  C CA  . GLU   A 1 103 ? -4.33711  -3.85533  29.21104  1.000 16.00106 ? 100 GLU   A CA  1 
ATOM   671  C C   . GLU   A 1 103 ? -4.66344  -2.40760  29.52764  1.000 19.33220 ? 100 GLU   A C   1 
ATOM   672  O O   . GLU   A 1 103 ? -5.23587  -2.10772  30.58086  1.000 22.83122 ? 100 GLU   A O   1 
ATOM   673  C CB  . GLU   A 1 103 ? -2.90680  -4.17177  29.64047  1.000 17.09707 ? 100 GLU   A CB  1 
ATOM   674  C CG  . GLU   A 1 103 ? -2.77785  -4.16878  31.15537  1.000 21.37933 ? 100 GLU   A CG  1 
ATOM   675  C CD  . GLU   A 1 103 ? -1.39328  -4.50091  31.66464  1.000 27.08981 ? 100 GLU   A CD  1 
ATOM   676  O OE1 . GLU   A 1 103 ? -0.55754  -5.01461  30.89244  1.000 26.76259 ? 100 GLU   A OE1 1 
ATOM   677  O OE2 . GLU   A 1 103 ? -1.13696  -4.24368  32.86079  1.000 32.63079 ? 100 GLU   A OE2 1 
ATOM   678  N N   . GLU   A 1 104 ? -4.31114  -1.50197  28.62165  1.000 17.07255 ? 101 GLU   A N   1 
ATOM   679  C CA  . GLU   A 1 104 ? -4.54609  -0.07158  28.77618  1.000 19.90390 ? 101 GLU   A CA  1 
ATOM   680  C C   . GLU   A 1 104 ? -4.96599  0.48111   27.43000  1.000 18.65986 ? 101 GLU   A C   1 
ATOM   681  O O   . GLU   A 1 104 ? -4.63468  -0.08456  26.38982  1.000 21.04163 ? 101 GLU   A O   1 
ATOM   682  C CB  . GLU   A 1 104 ? -3.28257  0.66359   29.25076  1.000 20.08592 ? 101 GLU   A CB  1 
ATOM   683  C CG  . GLU   A 1 104 ? -2.70103  0.15163   30.55813  1.000 25.40643 ? 101 GLU   A CG  1 
ATOM   684  C CD  . GLU   A 1 104 ? -3.37586  0.75613   31.76948  1.000 30.13524 ? 101 GLU   A CD  1 
ATOM   685  O OE1 . GLU   A 1 104 ? -4.42653  1.40990   31.60521  1.000 32.37092 ? 101 GLU   A OE1 1 
ATOM   686  O OE2 . GLU   A 1 104 ? -2.84403  0.59386   32.88731  1.000 31.11687 ? 101 GLU   A OE2 1 
ATOM   687  N N   . ASP   A 1 105 ? -5.69227  1.59155   27.42932  1.000 17.32885 ? 102 ASP   A N   1 
ATOM   688  C CA  . ASP   A 1 105 ? -5.89694  2.22814   26.13797  1.000 15.78796 ? 102 ASP   A CA  1 
ATOM   689  C C   . ASP   A 1 105 ? -4.87767  3.33881   25.93569  1.000 13.99793 ? 102 ASP   A C   1 
ATOM   690  O O   . ASP   A 1 105 ? -4.25049  3.83247   26.87998  1.000 14.28611 ? 102 ASP   A O   1 
ATOM   691  C CB  . ASP   A 1 105 ? -7.31628  2.76230   25.94799  1.000 26.03824 ? 102 ASP   A CB  1 
ATOM   692  C CG  . ASP   A 1 105 ? -7.85105  3.43537   27.15557  1.000 29.15159 ? 102 ASP   A CG  1 
ATOM   693  O OD1 . ASP   A 1 105 ? -7.25302  4.44569   27.57080  1.000 30.44794 ? 102 ASP   A OD1 1 
ATOM   694  O OD2 . ASP   A 1 105 ? -8.89639  2.97231   27.67352  1.000 36.68625 ? 102 ASP   A OD2 1 
ATOM   695  N N   . PHE   A 1 106 ? -4.68472  3.68257   24.66669  1.000 15.59171 ? 103 PHE   A N   1 
ATOM   696  C CA  . PHE   A 1 106 ? -3.71604  4.71269   24.31295  1.000 16.04190 ? 103 PHE   A CA  1 
ATOM   697  C C   . PHE   A 1 106 ? -3.99848  6.00423   25.07090  1.000 14.44323 ? 103 PHE   A C   1 
ATOM   698  O O   . PHE   A 1 106 ? -3.08263  6.65227   25.59242  1.000 13.07766 ? 103 PHE   A O   1 
ATOM   699  C CB  . PHE   A 1 106 ? -3.74411  4.94321   22.79967  1.000 14.36838 ? 103 PHE   A CB  1 
ATOM   700  C CG  . PHE   A 1 106 ? -2.99064  6.16868   22.35900  1.000 14.23814 ? 103 PHE   A CG  1 
ATOM   701  C CD1 . PHE   A 1 106 ? -3.60385  7.41139   22.35832  1.000 17.33822 ? 103 PHE   A CD1 1 
ATOM   702  C CD2 . PHE   A 1 106 ? -1.67550  6.07748   21.93432  1.000 15.67674 ? 103 PHE   A CD2 1 
ATOM   703  C CE1 . PHE   A 1 106 ? -2.91391  8.54458   21.96264  1.000 17.45985 ? 103 PHE   A CE1 1 
ATOM   704  C CE2 . PHE   A 1 106 ? -0.97702  7.21377   21.52818  1.000 17.22826 ? 103 PHE   A CE2 1 
ATOM   705  C CZ  . PHE   A 1 106 ? -1.59767  8.44985   21.55226  1.000 14.61809 ? 103 PHE   A CZ  1 
ATOM   706  N N   . GLU   A 1 107 ? -5.27042  6.39921   25.13009  1.000 14.47957 ? 104 GLU   A N   1 
ATOM   707  C CA  . GLU   A 1 107 ? -5.61956  7.69341   25.71061  1.000 13.11533 ? 104 GLU   A CA  1 
ATOM   708  C C   . GLU   A 1 107 ? -5.27843  7.75376   27.19254  1.000 15.10984 ? 104 GLU   A C   1 
ATOM   709  O O   . GLU   A 1 107 ? -4.86355  8.80641   27.70211  1.000 14.82176 ? 104 GLU   A O   1 
ATOM   710  C CB  . GLU   A 1 107 ? -7.10821  7.96467   25.49020  1.000 15.61593 ? 104 GLU   A CB  1 
ATOM   711  C CG  . GLU   A 1 107 ? -7.51131  8.07096   24.02284  1.000 20.49116 ? 104 GLU   A CG  1 
ATOM   712  C CD  . GLU   A 1 107 ? -7.68881  6.71952   23.31382  1.000 22.98036 ? 104 GLU   A CD  1 
ATOM   713  O OE1 . GLU   A 1 107 ? -7.67601  5.63926   23.96270  1.000 22.63935 ? 104 GLU   A OE1 1 
ATOM   714  O OE2 . GLU   A 1 107 ? -7.85796  6.74443   22.07945  1.000 38.08124 ? 104 GLU   A OE2 1 
ATOM   715  N N   . SER   A 1 108 ? -5.45659  6.63933   27.90535  1.000 13.44830 ? 105 SER   A N   1 
ATOM   716  C CA  . SER   A 1 108 ? -5.10512  6.60614   29.31977  1.000 14.02215 ? 105 SER   A CA  1 
ATOM   717  C C   . SER   A 1 108 ? -3.60547  6.73236   29.50074  1.000 13.14012 ? 105 SER   A C   1 
ATOM   718  O O   . SER   A 1 108 ? -3.13163  7.49673   30.35135  1.000 14.75227 ? 105 SER   A O   1 
ATOM   719  C CB  . SER   A 1 108 ? -5.60157  5.31046   29.96248  1.000 17.57492 ? 105 SER   A CB  1 
ATOM   720  O OG  . SER   A 1 108 ? -7.00098  5.17634   29.80742  1.000 24.33081 ? 105 SER   A OG  1 
ATOM   721  N N   . LEU   A 1 109 ? -2.83645  5.98477   28.70727  1.000 13.77785 ? 106 LEU   A N   1 
ATOM   722  C CA  . LEU   A 1 109 ? -1.38514  6.05142   28.84888  1.000 12.63497 ? 106 LEU   A CA  1 
ATOM   723  C C   . LEU   A 1 109 ? -0.85360  7.42631   28.46121  1.000 14.10233 ? 106 LEU   A C   1 
ATOM   724  O O   . LEU   A 1 109 ? 0.09059   7.92401   29.08496  1.000 13.42488 ? 106 LEU   A O   1 
ATOM   725  C CB  . LEU   A 1 109 ? -0.71985  4.94751   28.02066  1.000 13.69578 ? 106 LEU   A CB  1 
ATOM   726  C CG  . LEU   A 1 109 ? -1.00834  3.51660   28.50111  1.000 13.94439 ? 106 LEU   A CG  1 
ATOM   727  C CD1 . LEU   A 1 109 ? -0.37657  2.49664   27.56798  1.000 16.63808 ? 106 LEU   A CD1 1 
ATOM   728  C CD2 . LEU   A 1 109 ? -0.48157  3.33216   29.92825  1.000 16.99820 ? 106 LEU   A CD2 1 
ATOM   729  N N   . ALA   A 1 110 ? -1.41922  8.04850   27.41827  1.000 13.94477 ? 107 ALA   A N   1 
ATOM   730  C CA  . ALA   A 1 110 ? -1.01968  9.41692   27.09765  1.000 12.73762 ? 107 ALA   A CA  1 
ATOM   731  C C   . ALA   A 1 110 ? -1.31729  10.34826  28.26075  1.000 12.77155 ? 107 ALA   A C   1 
ATOM   732  O O   . ALA   A 1 110 ? -0.47095  11.16564  28.64534  1.000 13.63388 ? 107 ALA   A O   1 
ATOM   733  C CB  . ALA   A 1 110 ? -1.73061  9.90595   25.83753  1.000 12.33047 ? 107 ALA   A CB  1 
ATOM   734  N N   . SER   A 1 111 ? -2.50749  10.22311  28.85176  1.000 11.63513 ? 108 SER   A N   1 
ATOM   735  C CA  . SER   A 1 111 ? -2.85574  11.11833  29.94733  1.000 11.72323 ? 108 SER   A CA  1 
ATOM   736  C C   . SER   A 1 111 ? -1.92404  10.93453  31.13258  1.000 13.29834 ? 108 SER   A C   1 
ATOM   737  O O   . SER   A 1 111 ? -1.53625  11.91324  31.79147  1.000 15.48191 ? 108 SER   A O   1 
ATOM   738  C CB  . SER   A 1 111 ? -4.30361  10.87375  30.36507  1.000 12.56710 ? 108 SER   A CB  1 
ATOM   739  O OG  . SER   A 1 111 ? -4.63901  11.68605  31.48402  1.000 19.26928 ? 108 SER   A OG  1 
ATOM   740  N N   . GLN   A 1 112 ? -1.57796  9.67897   31.43797  1.000 12.47982 ? 109 GLN   A N   1 
ATOM   741  C CA  . GLN   A 1 112 ? -0.79465  9.33687   32.62264  1.000 13.66491 ? 109 GLN   A CA  1 
ATOM   742  C C   . GLN   A 1 112 ? 0.69962   9.56471   32.42797  1.000 13.53568 ? 109 GLN   A C   1 
ATOM   743  O O   . GLN   A 1 112 ? 1.38466   10.00900  33.35965  1.000 15.71800 ? 109 GLN   A O   1 
ATOM   744  C CB  . GLN   A 1 112 ? -1.05141  7.87300   32.99882  1.000 14.72385 ? 109 GLN   A CB  1 
ATOM   745  C CG  . GLN   A 1 112 ? -2.52279  7.59362   33.37096  1.000 14.26326 ? 109 GLN   A CG  1 
ATOM   746  C CD  . GLN   A 1 112 ? -2.87426  6.11938   33.42621  1.000 19.09553 ? 109 GLN   A CD  1 
ATOM   747  O OE1 . GLN   A 1 112 ? -2.07209  5.25965   33.08617  1.000 20.77013 ? 109 GLN   A OE1 1 
ATOM   748  N NE2 . GLN   A 1 112 ? -4.09734  5.82510   33.85081  1.000 21.87113 ? 109 GLN   A NE2 1 
ATOM   749  N N   . PHE   A 1 113 ? 1.23031   9.26576   31.23793  1.000 13.55630 ? 110 PHE   A N   1 
ATOM   750  C CA  . PHE   A 1 113 ? 2.67598   9.13175   31.08018  1.000 13.94377 ? 110 PHE   A CA  1 
ATOM   751  C C   . PHE   A 1 113 ? 3.31779   9.98145   29.98919  1.000 14.24770 ? 110 PHE   A C   1 
ATOM   752  O O   . PHE   A 1 113 ? 4.55418   10.02225  29.92523  1.000 14.27251 ? 110 PHE   A O   1 
ATOM   753  C CB  . PHE   A 1 113 ? 3.04250   7.65526   30.82704  1.000 15.74292 ? 110 PHE   A CB  1 
ATOM   754  C CG  . PHE   A 1 113 ? 2.66536   6.74047   31.96964  1.000 13.81469 ? 110 PHE   A CG  1 
ATOM   755  C CD1 . PHE   A 1 113 ? 3.25763   6.89674   33.21000  1.000 18.77848 ? 110 PHE   A CD1 1 
ATOM   756  C CD2 . PHE   A 1 113 ? 1.72777   5.72965   31.79790  1.000 16.43178 ? 110 PHE   A CD2 1 
ATOM   757  C CE1 . PHE   A 1 113 ? 2.91788   6.06166   34.26729  1.000 19.33461 ? 110 PHE   A CE1 1 
ATOM   758  C CE2 . PHE   A 1 113 ? 1.38182   4.89433   32.85649  1.000 17.52458 ? 110 PHE   A CE2 1 
ATOM   759  C CZ  . PHE   A 1 113 ? 1.97165   5.06807   34.08715  1.000 19.76166 ? 110 PHE   A CZ  1 
ATOM   760  N N   . SER   A 1 114 ? 2.55495   10.66071  29.13566  1.000 12.23945 ? 111 SER   A N   1 
ATOM   761  C CA  . SER   A 1 114 ? 3.21290   11.45088  28.10965  1.000 13.17049 ? 111 SER   A CA  1 
ATOM   762  C C   . SER   A 1 114 ? 3.95957   12.61205  28.74146  1.000 12.95837 ? 111 SER   A C   1 
ATOM   763  O O   . SER   A 1 114 ? 3.43646   13.29663  29.62518  1.000 15.07189 ? 111 SER   A O   1 
ATOM   764  C CB  . SER   A 1 114 ? 2.21362   11.98399  27.08668  1.000 11.97512 ? 111 SER   A CB  1 
ATOM   765  O OG  . SER   A 1 114 ? 2.91173   12.70254  26.07917  1.000 12.46385 ? 111 SER   A OG  1 
ATOM   766  N N   . ASP   A 1 115 ? 5.19527   12.82880  28.28184  1.000 11.43333 ? 112 ASP   A N   1 
ATOM   767  C CA  . ASP   A 1 115 ? 5.97312   13.98985  28.70626  1.000 12.03965 ? 112 ASP   A CA  1 
ATOM   768  C C   . ASP   A 1 115 ? 5.67543   15.24321  27.88627  1.000 14.75979 ? 112 ASP   A C   1 
ATOM   769  O O   . ASP   A 1 115 ? 6.32098   16.27833  28.10051  1.000 18.25353 ? 112 ASP   A O   1 
ATOM   770  C CB  . ASP   A 1 115 ? 7.47438   13.67387  28.62401  1.000 13.30867 ? 112 ASP   A CB  1 
ATOM   771  C CG  . ASP   A 1 115 ? 7.95778   12.81617  29.76745  1.000 18.81771 ? 112 ASP   A CG  1 
ATOM   772  O OD1 . ASP   A 1 115 ? 7.64707   13.13587  30.92799  1.000 17.22514 ? 112 ASP   A OD1 1 
ATOM   773  O OD2 . ASP   A 1 115 ? 8.66257   11.82199  29.50966  1.000 16.22803 ? 112 ASP   A OD2 1 
ATOM   774  N N   . CYS   A 1 116 ? 4.73762   15.18528  26.94657  1.000 14.28846 ? 113 CYS   A N   1 
ATOM   775  C CA  . CYS   A 1 116 ? 4.36138   16.35948  26.17274  1.000 12.96046 ? 113 CYS   A CA  1 
ATOM   776  C C   . CYS   A 1 116 ? 3.27196   17.11769  26.92075  1.000 14.62278 ? 113 CYS   A C   1 
ATOM   777  O O   . CYS   A 1 116 ? 2.13380   16.64992  27.00121  1.000 17.11714 ? 113 CYS   A O   1 
ATOM   778  C CB  . CYS   A 1 116 ? 3.87633   15.95496  24.78816  1.000 14.05098 ? 113 CYS   A CB  1 
ATOM   779  S SG  . CYS   A 1 116 ? 3.33039   17.39643  23.84515  1.000 14.12598 ? 113 CYS   A SG  1 
ATOM   780  N N   . SER   A 1 117 ? 3.61261   18.30501  27.43649  1.000 19.10086 ? 114 SER   A N   1 
ATOM   781  C CA  . SER   A 1 117 ? 2.66199   19.07298  28.23126  1.000 21.80565 ? 114 SER   A CA  1 
ATOM   782  C C   . SER   A 1 117 ? 1.66870   19.83851  27.36319  1.000 23.21772 ? 114 SER   A C   1 
ATOM   783  O O   . SER   A 1 117 ? 0.54383   20.11393  27.80396  1.000 28.73304 ? 114 SER   A O   1 
ATOM   784  C CB  . SER   A 1 117 ? 3.42203   20.04147  29.14811  1.000 25.48642 ? 114 SER   A CB  1 
ATOM   785  O OG  . SER   A 1 117 ? 4.56824   19.42023  29.74745  1.000 26.61456 ? 114 SER   A OG  1 
ATOM   786  N N   . SER   A 1 118 ? 2.04157   20.16765  26.12604  1.000 17.75243 ? 115 SER   A N   1 
ATOM   787  C CA  . SER   A 1 118 ? 1.23366   21.07103  25.31504  1.000 16.21454 ? 115 SER   A CA  1 
ATOM   788  C C   . SER   A 1 118 ? 0.22820   20.38349  24.39765  1.000 16.40393 ? 115 SER   A C   1 
ATOM   789  O O   . SER   A 1 118 ? -0.62818  21.06657  23.82607  1.000 19.09097 ? 115 SER   A O   1 
ATOM   790  C CB  . SER   A 1 118 ? 2.15299   21.97490  24.49061  1.000 19.37464 ? 115 SER   A CB  1 
ATOM   791  O OG  . SER   A 1 118 ? 3.05298   21.17782  23.75367  1.000 20.51468 ? 115 SER   A OG  1 
ATOM   792  N N   . ALA   A 1 119 ? 0.30116   19.06422  24.21578  1.000 16.12941 ? 116 ALA   A N   1 
ATOM   793  C CA  . ALA   A 1 119 ? -0.79937  18.37058  23.57335  1.000 13.94650 ? 116 ALA   A CA  1 
ATOM   794  C C   . ALA   A 1 119 ? -1.98699  18.31238  24.52976  1.000 13.78131 ? 116 ALA   A C   1 
ATOM   795  O O   . ALA   A 1 119 ? -1.86007  18.58846  25.72849  1.000 17.48575 ? 116 ALA   A O   1 
ATOM   796  C CB  . ALA   A 1 119 ? -0.38441  16.94970  23.17526  1.000 15.62240 ? 116 ALA   A CB  1 
ATOM   797  N N   . LYS   A 1 120 ? -3.15141  17.95162  23.99315  1.000 15.63301 ? 117 LYS   A N   1 
ATOM   798  C CA  . LYS   A 1 120 ? -4.25847  17.62507  24.88162  1.000 14.82793 ? 117 LYS   A CA  1 
ATOM   799  C C   . LYS   A 1 120 ? -3.84813  16.43677  25.73575  1.000 14.72266 ? 117 LYS   A C   1 
ATOM   800  O O   . LYS   A 1 120 ? -2.95205  15.67181  25.37206  1.000 15.05680 ? 117 LYS   A O   1 
ATOM   801  C CB  . LYS   A 1 120 ? -5.53378  17.31734  24.09504  1.000 15.89716 ? 117 LYS   A CB  1 
ATOM   802  C CG  . LYS   A 1 120 ? -6.10257  18.54191  23.34157  1.000 22.48543 ? 117 LYS   A CG  1 
ATOM   803  C CD  . LYS   A 1 120 ? -7.41661  18.20487  22.65093  1.000 31.17955 ? 117 LYS   A CD  1 
ATOM   804  C CE  . LYS   A 1 120 ? -8.04211  19.43822  22.01391  1.000 39.72491 ? 117 LYS   A CE  1 
ATOM   805  N NZ  . LYS   A 1 120 ? -8.34340  20.48388  23.03530  1.000 46.29882 ? 117 LYS   A NZ  1 
ATOM   806  N N   . ALA   A 1 121 ? -4.49141  16.29789  26.90138  1.000 13.12795 ? 118 ALA   A N   1 
ATOM   807  C CA  . ALA   A 1 121 ? -4.06957  15.25704  27.83505  1.000 12.60812 ? 118 ALA   A CA  1 
ATOM   808  C C   . ALA   A 1 121 ? -4.14339  13.86616  27.21404  1.000 13.16391 ? 118 ALA   A C   1 
ATOM   809  O O   . ALA   A 1 121 ? -3.24385  13.04688  27.42197  1.000 13.18284 ? 118 ALA   A O   1 
ATOM   810  C CB  . ALA   A 1 121 ? -4.90462  15.31446  29.10853  1.000 14.21558 ? 118 ALA   A CB  1 
ATOM   811  N N   . ARG   A 1 122 ? -5.19599  13.57366  26.44868  1.000 14.18327 ? 119 ARG   A N   1 
ATOM   812  C CA  . ARG   A 1 122 ? -5.28008  12.24969  25.83875  1.000 12.49404 ? 119 ARG   A CA  1 
ATOM   813  C C   . ARG   A 1 122 ? -4.50159  12.15429  24.53120  1.000 13.55467 ? 119 ARG   A C   1 
ATOM   814  O O   . ARG   A 1 122 ? -4.61623  11.15142  23.81863  1.000 15.22916 ? 119 ARG   A O   1 
ATOM   815  C CB  . ARG   A 1 122 ? -6.74458  11.85396  25.65958  1.000 16.55835 ? 119 ARG   A CB  1 
ATOM   816  C CG  . ARG   A 1 122 ? -7.41614  11.64938  26.99750  1.000 16.57043 ? 119 ARG   A CG  1 
ATOM   817  C CD  . ARG   A 1 122 ? -8.89677  11.36058  26.84663  1.000 19.72207 ? 119 ARG   A CD  1 
ATOM   818  N NE  . ARG   A 1 122 ? -9.61518  12.54693  26.40923  1.000 22.06706 ? 119 ARG   A NE  1 
ATOM   819  C CZ  . ARG   A 1 122 ? -10.85957 12.53889  25.95414  1.000 30.92579 ? 119 ARG   A CZ  1 
ATOM   820  N NH1 . ARG   A 1 122 ? -11.55245 11.41753  25.86241  1.000 34.84582 ? 119 ARG   A NH1 1 
ATOM   821  N NH2 . ARG   A 1 122 ? -11.42039 13.68495  25.57960  1.000 33.65390 ? 119 ARG   A NH2 1 
ATOM   822  N N   . GLY   A 1 123 ? -3.68882  13.16020  24.20884  1.000 13.09444 ? 120 GLY   A N   1 
ATOM   823  C CA  . GLY   A 1 123 ? -2.66486  13.02814  23.18323  1.000 12.89889 ? 120 GLY   A CA  1 
ATOM   824  C C   . GLY   A 1 123 ? -2.83083  13.90259  21.95301  1.000 15.44599 ? 120 GLY   A C   1 
ATOM   825  O O   . GLY   A 1 123 ? -1.86234  14.06269  21.19682  1.000 13.45676 ? 120 GLY   A O   1 
ATOM   826  N N   . ASP   A 1 124 ? -4.00270  14.49653  21.73152  1.000 15.03563 ? 121 ASP   A N   1 
ATOM   827  C CA  . ASP   A 1 124 ? -4.28421  15.16677  20.46655  1.000 13.01527 ? 121 ASP   A CA  1 
ATOM   828  C C   . ASP   A 1 124 ? -3.36603  16.36327  20.22002  1.000 11.93792 ? 121 ASP   A C   1 
ATOM   829  O O   . ASP   A 1 124 ? -3.19338  17.22680  21.09204  1.000 15.59516 ? 121 ASP   A O   1 
ATOM   830  C CB  . ASP   A 1 124 ? -5.75734  15.59995  20.47507  1.000 14.12968 ? 121 ASP   A CB  1 
ATOM   831  C CG  . ASP   A 1 124 ? -6.20108  16.27819  19.18748  1.000 17.68882 ? 121 ASP   A CG  1 
ATOM   832  O OD1 . ASP   A 1 124 ? -5.77868  15.87172  18.08752  1.000 13.31201 ? 121 ASP   A OD1 1 
ATOM   833  O OD2 . ASP   A 1 124 ? -7.03735  17.20837  19.28364  1.000 19.68201 ? 121 ASP   A OD2 1 
ATOM   834  N N   . LEU   A 1 125 ? -2.75386  16.38519  19.03022  1.000 11.66638 ? 122 LEU   A N   1 
ATOM   835  C CA  . LEU   A 1 125 ? -1.94830  17.49791  18.54056  1.000 13.78045 ? 122 LEU   A CA  1 
ATOM   836  C C   . LEU   A 1 125 ? -2.70410  18.37669  17.55952  1.000 15.03722 ? 122 LEU   A C   1 
ATOM   837  O O   . LEU   A 1 125 ? -2.17267  19.41313  17.13140  1.000 16.37799 ? 122 LEU   A O   1 
ATOM   838  C CB  . LEU   A 1 125 ? -0.68989  16.97613  17.83236  1.000 14.58421 ? 122 LEU   A CB  1 
ATOM   839  C CG  . LEU   A 1 125 ? 0.26563   16.16839  18.70249  1.000 11.74547 ? 122 LEU   A CG  1 
ATOM   840  C CD1 . LEU   A 1 125 ? 1.30374   15.47907  17.82150  1.000 16.80702 ? 122 LEU   A CD1 1 
ATOM   841  C CD2 . LEU   A 1 125 ? 0.94110   17.07331  19.72183  1.000 14.89948 ? 122 LEU   A CD2 1 
ATOM   842  N N   . GLY   A 1 126 ? -3.90411  17.98778  17.18965  1.000 14.94809 ? 123 GLY   A N   1 
ATOM   843  C CA  . GLY   A 1 126 ? -4.63164  18.67417  16.14016  1.000 15.34181 ? 123 GLY   A CA  1 
ATOM   844  C C   . GLY   A 1 126 ? -4.13262  18.28765  14.76150  1.000 15.34453 ? 123 GLY   A C   1 
ATOM   845  O O   . GLY   A 1 126 ? -3.38217  17.32840  14.57614  1.000 17.38423 ? 123 GLY   A O   1 
ATOM   846  N N   . ALA   A 1 127 ? -4.58794  19.04734  13.76733  1.000 15.12905 ? 124 ALA   A N   1 
ATOM   847  C CA  . ALA   A 1 127 ? -4.23751  18.79054  12.38086  1.000 16.96030 ? 124 ALA   A CA  1 
ATOM   848  C C   . ALA   A 1 127 ? -2.98409  19.56718  11.98267  1.000 14.87194 ? 124 ALA   A C   1 
ATOM   849  O O   . ALA   A 1 127 ? -2.70948  20.65913  12.50258  1.000 16.73764 ? 124 ALA   A O   1 
ATOM   850  C CB  . ALA   A 1 127 ? -5.40191  19.15998  11.45618  1.000 19.37456 ? 124 ALA   A CB  1 
ATOM   851  N N   . PHE   A 1 128 ? -2.22517  18.99703  11.04404  1.000 16.28859 ? 125 PHE   A N   1 
ATOM   852  C CA  . PHE   A 1 128 ? -1.01580  19.65294  10.55767  1.000 14.15083 ? 125 PHE   A CA  1 
ATOM   853  C C   . PHE   A 1 128 ? -0.69801  19.19018  9.14570   1.000 16.89186 ? 125 PHE   A C   1 
ATOM   854  O O   . PHE   A 1 128 ? -1.16894  18.14492  8.68084   1.000 17.53057 ? 125 PHE   A O   1 
ATOM   855  C CB  . PHE   A 1 128 ? 0.19830   19.41385  11.48086  1.000 16.94736 ? 125 PHE   A CB  1 
ATOM   856  C CG  . PHE   A 1 128 ? 0.50221   17.95913  11.74418  1.000 17.11937 ? 125 PHE   A CG  1 
ATOM   857  C CD1 . PHE   A 1 128 ? -0.14488  17.28723  12.76592  1.000 14.44527 ? 125 PHE   A CD1 1 
ATOM   858  C CD2 . PHE   A 1 128 ? 1.43183   17.26690  10.97384  1.000 14.73585 ? 125 PHE   A CD2 1 
ATOM   859  C CE1 . PHE   A 1 128 ? 0.12303   15.93539  13.01745  1.000 17.39477 ? 125 PHE   A CE1 1 
ATOM   860  C CE2 . PHE   A 1 128 ? 1.71856   15.92055  11.23194  1.000 16.41295 ? 125 PHE   A CE2 1 
ATOM   861  C CZ  . PHE   A 1 128 ? 1.06033   15.26260  12.24811  1.000 17.81486 ? 125 PHE   A CZ  1 
ATOM   862  N N   . SER   A 1 129 ? 0.12274   19.99107  8.47333   1.000 15.61963 ? 126 SER   A N   1 
ATOM   863  C CA  . SER   A 1 129 ? 0.53232   19.76377  7.09714   1.000 17.32355 ? 126 SER   A CA  1 
ATOM   864  C C   . SER   A 1 129 ? 1.98497   19.32398  7.05337   1.000 14.62048 ? 126 SER   A C   1 
ATOM   865  O O   . SER   A 1 129 ? 2.72437   19.42487  8.03638   1.000 17.22216 ? 126 SER   A O   1 
ATOM   866  C CB  . SER   A 1 129 ? 0.35423   21.04132  6.26327   1.000 17.63363 ? 126 SER   A CB  1 
ATOM   867  O OG  . SER   A 1 129 ? -0.99422  21.48005  6.31132   1.000 22.57225 ? 126 SER   A OG  1 
ATOM   868  N N   . ARG   A 1 130 ? 2.40700   18.85668  5.87826   1.000 14.64330 ? 127 ARG   A N   1 
ATOM   869  C CA  . ARG   A 1 130 ? 3.82643   18.62312  5.68200   1.000 14.95171 ? 127 ARG   A CA  1 
ATOM   870  C C   . ARG   A 1 130 ? 4.56489   19.94756  5.80415   1.000 17.04352 ? 127 ARG   A C   1 
ATOM   871  O O   . ARG   A 1 130 ? 4.03218   21.01164  5.47983   1.000 20.84450 ? 127 ARG   A O   1 
ATOM   872  C CB  . ARG   A 1 130 ? 4.08871   17.97684  4.32360   1.000 15.97532 ? 127 ARG   A CB  1 
ATOM   873  C CG  . ARG   A 1 130 ? 3.67603   16.49094  4.26128   1.000 16.67579 ? 127 ARG   A CG  1 
ATOM   874  C CD  . ARG   A 1 130 ? 4.38495   15.75299  3.14078   1.000 19.01510 ? 127 ARG   A CD  1 
ATOM   875  N NE  . ARG   A 1 130 ? 4.04740   14.33299  3.08111   1.000 18.71890 ? 127 ARG   A NE  1 
ATOM   876  C CZ  . ARG   A 1 130 ? 4.73872   13.36991  3.67527   1.000 15.71962 ? 127 ARG   A CZ  1 
ATOM   877  N NH1 . ARG   A 1 130 ? 5.76024   13.64164  4.46678   1.000 15.79688 ? 127 ARG   A NH1 1 
ATOM   878  N NH2 . ARG   A 1 130 ? 4.40008   12.10174  3.45881   1.000 17.06055 ? 127 ARG   A NH2 1 
ATOM   879  N N   . GLY   A 1 131 ? 5.77785   19.88159  6.33263   1.000 16.53837 ? 128 GLY   A N   1 
ATOM   880  C CA  . GLY   A 1 131 ? 6.60267   21.05695  6.51854   1.000 19.99736 ? 128 GLY   A CA  1 
ATOM   881  C C   . GLY   A 1 131 ? 6.56777   21.64401  7.90714   1.000 22.25457 ? 128 GLY   A C   1 
ATOM   882  O O   . GLY   A 1 131 ? 7.35921   22.54924  8.19594   1.000 23.61974 ? 128 GLY   A O   1 
ATOM   883  N N   . GLN   A 1 132 ? 5.69294   21.15275  8.78338   1.000 15.76591 ? 129 GLN   A N   1 
ATOM   884  C CA  . GLN   A 1 132 ? 5.51692   21.73474  10.10799  1.000 13.99573 ? 129 GLN   A CA  1 
ATOM   885  C C   . GLN   A 1 132 ? 6.23118   20.97358  11.21252  1.000 13.80729 ? 129 GLN   A C   1 
ATOM   886  O O   . GLN   A 1 132 ? 6.78107   21.59788  12.13154  1.000 17.10232 ? 129 GLN   A O   1 
ATOM   887  C CB  . GLN   A 1 132 ? 4.02309   21.82166  10.44686  1.000 15.46187 ? 129 GLN   A CB  1 
ATOM   888  C CG  . GLN   A 1 132 ? 3.25790   22.80396  9.57345   1.000 19.47144 ? 129 GLN   A CG  1 
ATOM   889  C CD  . GLN   A 1 132 ? 1.88232   23.10512  10.11479  1.000 24.95241 ? 129 GLN   A CD  1 
ATOM   890  O OE1 . GLN   A 1 132 ? 0.97006   22.29653  10.01062  1.000 18.79012 ? 129 GLN   A OE1 1 
ATOM   891  N NE2 . GLN   A 1 132 ? 1.72803   24.28103  10.71233  1.000 30.40822 ? 129 GLN   A NE2 1 
ATOM   892  N N   A MET   A 1 133 ? 6.25315   19.64816  11.14361  0.260 14.56750 ? 130 MET   A N   1 
ATOM   893  N N   B MET   A 1 133 ? 6.20830   19.63720  11.17312  0.740 14.43195 ? 130 MET   A N   1 
ATOM   894  C CA  A MET   A 1 133 ? 6.84749   18.81539  12.17547  0.260 15.66079 ? 130 MET   A CA  1 
ATOM   895  C CA  B MET   A 1 133 ? 6.83386   18.80287  12.19273  0.740 15.67192 ? 130 MET   A CA  1 
ATOM   896  C C   A MET   A 1 133 ? 8.15827   18.22547  11.67867  0.260 14.28150 ? 130 MET   A C   1 
ATOM   897  C C   B MET   A 1 133 ? 8.14568   18.22052  11.68309  0.740 14.15434 ? 130 MET   A C   1 
ATOM   898  O O   A MET   A 1 133 ? 8.43303   18.19938  10.47608  0.260 18.06614 ? 130 MET   A O   1 
ATOM   899  O O   B MET   A 1 133 ? 8.39670   18.16618  10.47779  0.740 18.18483 ? 130 MET   A O   1 
ATOM   900  C CB  A MET   A 1 133 ? 5.88466   17.69660  12.56609  0.260 15.84328 ? 130 MET   A CB  1 
ATOM   901  C CB  B MET   A 1 133 ? 5.91350   17.64828  12.59643  0.740 15.82195 ? 130 MET   A CB  1 
ATOM   902  C CG  A MET   A 1 133 ? 4.45040   18.08823  12.31801  0.260 17.00499 ? 130 MET   A CG  1 
ATOM   903  C CG  B MET   A 1 133 ? 4.49110   18.03440  12.83151  0.740 19.03436 ? 130 MET   A CG  1 
ATOM   904  S SD  A MET   A 1 133 ? 3.83057   19.09631  13.66105  0.260 25.95100 ? 130 MET   A SD  1 
ATOM   905  S SD  B MET   A 1 133 ? 4.44635   19.17957  14.20173  0.740 17.37961 ? 130 MET   A SD  1 
ATOM   906  C CE  A MET   A 1 133 ? 3.43040   17.75885  14.76139  0.260 9.26656  ? 130 MET   A CE  1 
ATOM   907  C CE  B MET   A 1 133 ? 2.67375   19.27945  14.47430  0.740 20.43541 ? 130 MET   A CE  1 
ATOM   908  N N   . GLN   A 1 134 ? 8.96811   17.74745  12.62262  1.000 14.01015 ? 131 GLN   A N   1 
ATOM   909  C CA  . GLN   A 1 134 ? 10.22922  17.11345  12.25278  1.000 13.25710 ? 131 GLN   A CA  1 
ATOM   910  C C   . GLN   A 1 134 ? 9.96853   15.92254  11.34473  1.000 15.17747 ? 131 GLN   A C   1 
ATOM   911  O O   . GLN   A 1 134 ? 8.99771   15.18581  11.52852  1.000 15.66169 ? 131 GLN   A O   1 
ATOM   912  C CB  . GLN   A 1 134 ? 10.99521  16.66921  13.48724  1.000 17.42442 ? 131 GLN   A CB  1 
ATOM   913  C CG  . GLN   A 1 134 ? 11.67052  17.82913  14.17250  1.000 21.24590 ? 131 GLN   A CG  1 
ATOM   914  C CD  . GLN   A 1 134 ? 12.91061  17.40996  14.90556  1.000 35.36276 ? 131 GLN   A CD  1 
ATOM   915  O OE1 . GLN   A 1 134 ? 12.85891  16.56571  15.79504  1.000 19.66086 ? 131 GLN   A OE1 1 
ATOM   916  N NE2 . GLN   A 1 134 ? 14.04717  17.98633  14.52628  1.000 43.31181 ? 131 GLN   A NE2 1 
ATOM   917  N N   . LYS   A 1 135 ? 10.83123  15.76090  10.34398  1.000 15.97206 ? 132 LYS   A N   1 
ATOM   918  C CA  . LYS   A 1 135 ? 10.58890  14.80562  9.26444   1.000 15.36532 ? 132 LYS   A CA  1 
ATOM   919  C C   . LYS   A 1 135 ? 10.24371  13.38622  9.71762   1.000 14.14232 ? 132 LYS   A C   1 
ATOM   920  O O   . LYS   A 1 135 ? 9.32124   12.80008  9.12813   1.000 13.56323 ? 132 LYS   A O   1 
ATOM   921  C CB  . LYS   A 1 135 ? 11.80733  14.78115  8.32652   1.000 18.28149 ? 132 LYS   A CB  1 
ATOM   922  C CG  . LYS   A 1 135 ? 11.59802  13.91928  7.08420   1.000 20.89312 ? 132 LYS   A CG  1 
ATOM   923  C CD  . LYS   A 1 135 ? 12.74094  14.08860  6.08700   1.000 29.96236 ? 132 LYS   A CD  1 
ATOM   924  C CE  . LYS   A 1 135 ? 12.32071  13.68946  4.67522   1.000 39.01448 ? 132 LYS   A CE  1 
ATOM   925  N NZ  . LYS   A 1 135 ? 11.87200  12.27606  4.57539   1.000 32.75647 ? 132 LYS   A NZ  1 
ATOM   926  N N   . PRO   A 1 136 ? 10.92079  12.76899  10.70108  1.000 14.61331 ? 133 PRO   A N   1 
ATOM   927  C CA  . PRO   A 1 136 ? 10.52162  11.40021  11.08667  1.000 13.47682 ? 133 PRO   A CA  1 
ATOM   928  C C   . PRO   A 1 136 ? 9.08420   11.32625  11.57392  1.000 13.46859 ? 133 PRO   A C   1 
ATOM   929  O O   . PRO   A 1 136 ? 8.35189   10.37427  11.25434  1.000 14.82869 ? 133 PRO   A O   1 
ATOM   930  C CB  . PRO   A 1 136 ? 11.51749  11.04034  12.20021  1.000 19.26286 ? 133 PRO   A CB  1 
ATOM   931  C CG  . PRO   A 1 136 ? 12.68694  11.94928  11.97845  1.000 19.19877 ? 133 PRO   A CG  1 
ATOM   932  C CD  . PRO   A 1 136 ? 12.10889  13.21956  11.45081  1.000 18.36501 ? 133 PRO   A CD  1 
ATOM   933  N N   . PHE   A 1 137 ? 8.65465   12.34340  12.32516  1.000 11.88125 ? 134 PHE   A N   1 
ATOM   934  C CA  . PHE   A 1 137 ? 7.29692   12.37416  12.85367  1.000 13.58680 ? 134 PHE   A CA  1 
ATOM   935  C C   . PHE   A 1 137 ? 6.29165   12.66504  11.74606  1.000 12.50015 ? 134 PHE   A C   1 
ATOM   936  O O   . PHE   A 1 137 ? 5.24325   12.01146  11.64941  1.000 12.35388 ? 134 PHE   A O   1 
ATOM   937  C CB  . PHE   A 1 137 ? 7.21900   13.42529  13.96563  1.000 14.41691 ? 134 PHE   A CB  1 
ATOM   938  C CG  . PHE   A 1 137 ? 5.92422   13.43131  14.70590  1.000 11.80909 ? 134 PHE   A CG  1 
ATOM   939  C CD1 . PHE   A 1 137 ? 4.81133   14.06676  14.17272  1.000 13.06315 ? 134 PHE   A CD1 1 
ATOM   940  C CD2 . PHE   A 1 137 ? 5.81126   12.80436  15.93948  1.000 12.54933 ? 134 PHE   A CD2 1 
ATOM   941  C CE1 . PHE   A 1 137 ? 3.58777   14.05208  14.84361  1.000 13.90542 ? 134 PHE   A CE1 1 
ATOM   942  C CE2 . PHE   A 1 137 ? 4.59858   12.80881  16.63152  1.000 11.49900 ? 134 PHE   A CE2 1 
ATOM   943  C CZ  . PHE   A 1 137 ? 3.49110   13.41789  16.08111  1.000 13.86872 ? 134 PHE   A CZ  1 
ATOM   944  N N   . GLU   A 1 138 ? 6.59931   13.64894  10.89800  1.000 13.70014 ? 135 GLU   A N   1 
ATOM   945  C CA  . GLU   A 1 138 ? 5.76283   13.94054  9.73904   1.000 11.63991 ? 135 GLU   A CA  1 
ATOM   946  C C   . GLU   A 1 138 ? 5.58284   12.71216  8.84997   1.000 12.79904 ? 135 GLU   A C   1 
ATOM   947  O O   . GLU   A 1 138 ? 4.45586   12.35053  8.49669   1.000 13.37185 ? 135 GLU   A O   1 
ATOM   948  C CB  . GLU   A 1 138 ? 6.38802   15.07623  8.93301   1.000 13.08397 ? 135 GLU   A CB  1 
ATOM   949  C CG  . GLU   A 1 138 ? 5.72039   15.26717  7.58918   1.000 14.73951 ? 135 GLU   A CG  1 
ATOM   950  C CD  . GLU   A 1 138 ? 6.40632   16.35792  6.77738   1.000 16.42538 ? 135 GLU   A CD  1 
ATOM   951  O OE1 . GLU   A 1 138 ? 6.65493   17.44063  7.34319   1.000 16.85624 ? 135 GLU   A OE1 1 
ATOM   952  O OE2 . GLU   A 1 138 ? 6.72271   16.12456  5.58942   1.000 19.89907 ? 135 GLU   A OE2 1 
ATOM   953  N N   . ASP   A 1 139 ? 6.68497   12.06247  8.46914   1.000 13.54981 ? 136 ASP   A N   1 
ATOM   954  C CA  . ASP   A 1 139 ? 6.58151   10.91898  7.56077   1.000 12.29393 ? 136 ASP   A CA  1 
ATOM   955  C C   . ASP   A 1 139 ? 5.76264   9.79069   8.17916   1.000 12.43674 ? 136 ASP   A C   1 
ATOM   956  O O   . ASP   A 1 139 ? 4.92145   9.18520   7.50771   1.000 14.09309 ? 136 ASP   A O   1 
ATOM   957  C CB  . ASP   A 1 139 ? 7.97274   10.39988  7.18081   1.000 13.28745 ? 136 ASP   A CB  1 
ATOM   958  C CG  . ASP   A 1 139 ? 8.71860   11.31323  6.20859   1.000 18.33745 ? 136 ASP   A CG  1 
ATOM   959  O OD1 . ASP   A 1 139 ? 8.10204   12.19547  5.57304   1.000 17.76793 ? 136 ASP   A OD1 1 
ATOM   960  O OD2 . ASP   A 1 139 ? 9.95177   11.11841  6.07384   1.000 17.67945 ? 136 ASP   A OD2 1 
ATOM   961  N N   . ALA   A 1 140 ? 6.00100   9.48744   9.45866   1.000 13.03436 ? 137 ALA   A N   1 
ATOM   962  C CA  . ALA   A 1 140 ? 5.21408   8.44844   10.11512  1.000 13.08834 ? 137 ALA   A CA  1 
ATOM   963  C C   . ALA   A 1 140 ? 3.73762   8.81002   10.11478  1.000 14.42602 ? 137 ALA   A C   1 
ATOM   964  O O   . ALA   A 1 140 ? 2.88948   7.96715   9.79931   1.000 13.62160 ? 137 ALA   A O   1 
ATOM   965  C CB  . ALA   A 1 140 ? 5.71432   8.22489   11.54357  1.000 12.94732 ? 137 ALA   A CB  1 
ATOM   966  N N   . SER   A 1 141 ? 3.41756   10.07614  10.43214  1.000 13.50462 ? 138 SER   A N   1 
ATOM   967  C CA  . SER   A 1 141 ? 2.02114   10.49266  10.55927  1.000 13.02194 ? 138 SER   A CA  1 
ATOM   968  C C   . SER   A 1 141 ? 1.27070   10.34953  9.24196   1.000 13.52727 ? 138 SER   A C   1 
ATOM   969  O O   . SER   A 1 141 ? 0.11515   9.90569   9.22578   1.000 15.27644 ? 138 SER   A O   1 
ATOM   970  C CB  . SER   A 1 141 ? 1.94648   11.94234  11.05626  1.000 12.16825 ? 138 SER   A CB  1 
ATOM   971  O OG  . SER   A 1 141 ? 2.49578   12.09642  12.36018  1.000 13.77993 ? 138 SER   A OG  1 
ATOM   972  N N   . PHE   A 1 142 ? 1.90431   10.72570  8.12291   1.000 14.39850 ? 139 PHE   A N   1 
ATOM   973  C CA  . PHE   A 1 142 ? 1.21563   10.63238  6.84359   1.000 13.67279 ? 139 PHE   A CA  1 
ATOM   974  C C   . PHE   A 1 142 ? 1.19616   9.21673   6.28432   1.000 16.79892 ? 139 PHE   A C   1 
ATOM   975  O O   . PHE   A 1 142 ? 0.35625   8.91768   5.42999   1.000 18.83729 ? 139 PHE   A O   1 
ATOM   976  C CB  . PHE   A 1 142 ? 1.83423   11.60503  5.82600   1.000 15.24402 ? 139 PHE   A CB  1 
ATOM   977  C CG  . PHE   A 1 142 ? 1.35862   13.02271  5.97786   1.000 13.84145 ? 139 PHE   A CG  1 
ATOM   978  C CD1 . PHE   A 1 142 ? 1.95624   13.88174  6.89298   1.000 13.91142 ? 139 PHE   A CD1 1 
ATOM   979  C CD2 . PHE   A 1 142 ? 0.28463   13.48074  5.23307   1.000 17.17290 ? 139 PHE   A CD2 1 
ATOM   980  C CE1 . PHE   A 1 142 ? 1.51184   15.17348  7.04391   1.000 17.19343 ? 139 PHE   A CE1 1 
ATOM   981  C CE2 . PHE   A 1 142 ? -0.15732  14.78160  5.37599   1.000 17.26684 ? 139 PHE   A CE2 1 
ATOM   982  C CZ  . PHE   A 1 142 ? 0.44350   15.62419  6.28044   1.000 17.44434 ? 139 PHE   A CZ  1 
ATOM   983  N N   . ALA   A 1 143 ? 2.07579   8.33135   6.75894   1.000 13.77145 ? 140 ALA   A N   1 
ATOM   984  C CA  . ALA   A 1 143 ? 2.08145   6.94250   6.31958   1.000 13.88157 ? 140 ALA   A CA  1 
ATOM   985  C C   . ALA   A 1 143 ? 1.12113   6.06618   7.11438   1.000 16.43193 ? 140 ALA   A C   1 
ATOM   986  O O   . ALA   A 1 143 ? 0.80420   4.95491   6.66692   1.000 18.34167 ? 140 ALA   A O   1 
ATOM   987  C CB  . ALA   A 1 143 ? 3.50441   6.37401   6.40359   1.000 14.18815 ? 140 ALA   A CB  1 
ATOM   988  N N   . LEU   A 1 144 ? 0.62712   6.54450   8.25519   1.000 13.43584 ? 141 LEU   A N   1 
ATOM   989  C CA  . LEU   A 1 144 ? -0.46620  5.86700   8.94570   1.000 16.11932 ? 141 LEU   A CA  1 
ATOM   990  C C   . LEU   A 1 144 ? -1.77516  6.13883   8.22675   1.000 16.80214 ? 141 LEU   A C   1 
ATOM   991  O O   . LEU   A 1 144 ? -2.01659  7.25809   7.76954   1.000 16.33790 ? 141 LEU   A O   1 
ATOM   992  C CB  . LEU   A 1 144 ? -0.59002  6.36231   10.38476  1.000 13.83552 ? 141 LEU   A CB  1 
ATOM   993  C CG  . LEU   A 1 144 ? 0.58503   6.10185   11.31402  1.000 11.14286 ? 141 LEU   A CG  1 
ATOM   994  C CD1 . LEU   A 1 144 ? 0.47716   7.00188   12.54801  1.000 14.79339 ? 141 LEU   A CD1 1 
ATOM   995  C CD2 . LEU   A 1 144 ? 0.63222   4.63277   11.71058  1.000 13.72022 ? 141 LEU   A CD2 1 
ATOM   996  N N   . ARG   A 1 145 ? -2.61938  5.11473   8.12349   1.000 14.63497 ? 142 ARG   A N   1 
ATOM   997  C CA  . ARG   A 1 145 ? -4.00367  5.36875   7.77855   1.000 13.37613 ? 142 ARG   A CA  1 
ATOM   998  C C   . ARG   A 1 145 ? -4.77373  5.73473   9.04572   1.000 16.87177 ? 142 ARG   A C   1 
ATOM   999  O O   . ARG   A 1 145 ? -4.30056  5.52699   10.17069  1.000 16.36171 ? 142 ARG   A O   1 
ATOM   1000 C CB  . ARG   A 1 145 ? -4.63208  4.15196   7.08818   1.000 17.19225 ? 142 ARG   A CB  1 
ATOM   1001 C CG  . ARG   A 1 145 ? -4.27135  4.01668   5.60251   1.000 22.55123 ? 142 ARG   A CG  1 
ATOM   1002 C CD  . ARG   A 1 145 ? -2.92162  3.37198   5.36523   1.000 23.00155 ? 142 ARG   A CD  1 
ATOM   1003 N NE  . ARG   A 1 145 ? -2.81789  2.06302   5.99972   1.000 22.73258 ? 142 ARG   A NE  1 
ATOM   1004 C CZ  . ARG   A 1 145 ? -3.32024  0.94475   5.49436   1.000 28.09988 ? 142 ARG   A CZ  1 
ATOM   1005 N NH1 . ARG   A 1 145 ? -3.95175  0.93368   4.33124   1.000 31.30969 ? 142 ARG   A NH1 1 
ATOM   1006 N NH2 . ARG   A 1 145 ? -3.18433  -0.19138  6.17263   1.000 26.28487 ? 142 ARG   A NH2 1 
ATOM   1007 N N   . THR   A 1 146 ? -5.97397  6.28787   8.86579   1.000 15.51929 ? 143 THR   A N   1 
ATOM   1008 C CA  . THR   A 1 146 ? -6.79000  6.65202   10.01660  1.000 16.47625 ? 143 THR   A CA  1 
ATOM   1009 C C   . THR   A 1 146 ? -7.00813  5.43690   10.91154  1.000 19.83558 ? 143 THR   A C   1 
ATOM   1010 O O   . THR   A 1 146 ? -7.35530  4.35388   10.43080  1.000 22.18919 ? 143 THR   A O   1 
ATOM   1011 C CB  . THR   A 1 146 ? -8.13285  7.21709   9.56261   1.000 20.47508 ? 143 THR   A CB  1 
ATOM   1012 O OG1 . THR   A 1 146 ? -7.91776  8.38766   8.76647   1.000 25.73242 ? 143 THR   A OG1 1 
ATOM   1013 C CG2 . THR   A 1 146 ? -8.96645  7.59632   10.75604  1.000 26.04985 ? 143 THR   A CG2 1 
ATOM   1014 N N   . GLY   A 1 147 ? -6.78988  5.61750   12.21612  1.000 16.00638 ? 144 GLY   A N   1 
ATOM   1015 C CA  . GLY   A 1 147 ? -6.92602  4.55115   13.17918  1.000 16.61141 ? 144 GLY   A CA  1 
ATOM   1016 C C   . GLY   A 1 147 ? -5.67796  3.72281   13.40039  1.000 15.02898 ? 144 GLY   A C   1 
ATOM   1017 O O   . GLY   A 1 147 ? -5.68629  2.83303   14.26791  1.000 18.36480 ? 144 GLY   A O   1 
ATOM   1018 N N   . GLU   A 1 148 ? -4.62290  3.95139   12.62515  1.000 13.87600 ? 145 GLU   A N   1 
ATOM   1019 C CA  . GLU   A 1 148 ? -3.40659  3.16933   12.80167  1.000 15.87799 ? 145 GLU   A CA  1 
ATOM   1020 C C   . GLU   A 1 148 ? -2.43405  3.85793   13.75556  1.000 14.09912 ? 145 GLU   A C   1 
ATOM   1021 O O   . GLU   A 1 148 ? -2.40220  5.08838   13.88834  1.000 13.78753 ? 145 GLU   A O   1 
ATOM   1022 C CB  . GLU   A 1 148 ? -2.71467  2.89167   11.46189  1.000 15.55308 ? 145 GLU   A CB  1 
ATOM   1023 C CG  . GLU   A 1 148 ? -3.43557  1.82779   10.61459  1.000 15.24635 ? 145 GLU   A CG  1 
ATOM   1024 C CD  . GLU   A 1 148 ? -2.64717  1.47495   9.37531   1.000 18.23326 ? 145 GLU   A CD  1 
ATOM   1025 O OE1 . GLU   A 1 148 ? -2.08655  2.39751   8.74898   1.000 16.74883 ? 145 GLU   A OE1 1 
ATOM   1026 O OE2 . GLU   A 1 148 ? -2.56173  0.28089   9.02372   1.000 20.64756 ? 145 GLU   A OE2 1 
ATOM   1027 N N   . MET   A 1 149 ? -1.62580  3.02631   14.41343  1.000 13.96949 ? 146 MET   A N   1 
ATOM   1028 C CA  . MET   A 1 149 ? -0.67675  3.44535   15.42911  1.000 13.71156 ? 146 MET   A CA  1 
ATOM   1029 C C   . MET   A 1 149 ? 0.74158   3.10993   14.99287  1.000 13.16105 ? 146 MET   A C   1 
ATOM   1030 O O   . MET   A 1 149 ? 0.99617   2.04308   14.42847  1.000 14.56478 ? 146 MET   A O   1 
ATOM   1031 C CB  . MET   A 1 149 ? -0.99969  2.75709   16.76259  1.000 13.02324 ? 146 MET   A CB  1 
ATOM   1032 C CG  . MET   A 1 149 ? -0.19084  3.28130   17.93048  1.000 12.90884 ? 146 MET   A CG  1 
ATOM   1033 S SD  . MET   A 1 149 ? -0.72172  2.58386   19.51390  1.000 15.95968 ? 146 MET   A SD  1 
ATOM   1034 C CE  . MET   A 1 149 ? -0.23151  0.88178   19.32949  1.000 20.28053 ? 146 MET   A CE  1 
ATOM   1035 N N   . SER   A 1 150 ? 1.66466   4.03065   15.24006  1.000 12.72988 ? 147 SER   A N   1 
ATOM   1036 C CA  . SER   A 1 150 ? 3.05129   3.80145   14.86687  1.000 11.28909 ? 147 SER   A CA  1 
ATOM   1037 C C   . SER   A 1 150 ? 3.73759   2.86995   15.85517  1.000 13.06713 ? 147 SER   A C   1 
ATOM   1038 O O   . SER   A 1 150 ? 3.21679   2.55960   16.92870  1.000 14.20215 ? 147 SER   A O   1 
ATOM   1039 C CB  . SER   A 1 150 ? 3.82353   5.12249   14.84640  1.000 12.41857 ? 147 SER   A CB  1 
ATOM   1040 O OG  . SER   A 1 150 ? 4.03565   5.61874   16.16238  1.000 11.23243 ? 147 SER   A OG  1 
ATOM   1041 N N   . GLY   A 1 151 ? 4.94864   2.45029   15.48544  1.000 13.50833 ? 148 GLY   A N   1 
ATOM   1042 C CA  . GLY   A 1 151 ? 5.92004   1.96168   16.43948  1.000 14.79038 ? 148 GLY   A CA  1 
ATOM   1043 C C   . GLY   A 1 151 ? 6.68490   3.13304   17.03115  1.000 14.09672 ? 148 GLY   A C   1 
ATOM   1044 O O   . GLY   A 1 151 ? 6.24369   4.28049   16.94720  1.000 13.16516 ? 148 GLY   A O   1 
ATOM   1045 N N   . PRO   A 1 152 ? 7.83057   2.87728   17.66213  1.000 11.12737 ? 149 PRO   A N   1 
ATOM   1046 C CA  . PRO   A 1 152 ? 8.60517   3.97950   18.25495  1.000 12.53034 ? 149 PRO   A CA  1 
ATOM   1047 C C   . PRO   A 1 152 ? 9.15541   4.87942   17.15875  1.000 12.41009 ? 149 PRO   A C   1 
ATOM   1048 O O   . PRO   A 1 152 ? 9.84734   4.41464   16.24557  1.000 15.05687 ? 149 PRO   A O   1 
ATOM   1049 C CB  . PRO   A 1 152 ? 9.73402   3.26844   19.01432  1.000 16.34284 ? 149 PRO   A CB  1 
ATOM   1050 C CG  . PRO   A 1 152 ? 9.42276   1.82675   18.97233  1.000 22.89402 ? 149 PRO   A CG  1 
ATOM   1051 C CD  . PRO   A 1 152 ? 8.48289   1.57335   17.84598  1.000 15.60132 ? 149 PRO   A CD  1 
ATOM   1052 N N   . VAL   A 1 153 ? 8.84512   6.17044   17.25012  1.000 12.71100 ? 150 VAL   A N   1 
ATOM   1053 C CA  . VAL   A 1 153 ? 9.31835   7.17272   16.30050  1.000 11.50508 ? 150 VAL   A CA  1 
ATOM   1054 C C   . VAL   A 1 153 ? 10.21390  8.15487   17.04049  1.000 12.52932 ? 150 VAL   A C   1 
ATOM   1055 O O   . VAL   A 1 153 ? 9.83625   8.67340   18.09525  1.000 13.24973 ? 150 VAL   A O   1 
ATOM   1056 C CB  . VAL   A 1 153 ? 8.14374   7.89707   15.62268  1.000 11.96083 ? 150 VAL   A CB  1 
ATOM   1057 C CG1 . VAL   A 1 153 ? 8.64250   9.05732   14.75720  1.000 12.91225 ? 150 VAL   A CG1 1 
ATOM   1058 C CG2 . VAL   A 1 153 ? 7.33352   6.91051   14.77304  1.000 13.04382 ? 150 VAL   A CG2 1 
ATOM   1059 N N   . PHE   A 1 154 ? 11.40642  8.40725   16.49668  1.000 13.03692 ? 151 PHE   A N   1 
ATOM   1060 C CA  . PHE   A 1 154 ? 12.42160  9.19044   17.20106  1.000 12.98111 ? 151 PHE   A CA  1 
ATOM   1061 C C   . PHE   A 1 154 ? 12.50141  10.60816  16.64151  1.000 14.45074 ? 151 PHE   A C   1 
ATOM   1062 O O   . PHE   A 1 154 ? 12.54975  10.79462  15.41735  1.000 15.20338 ? 151 PHE   A O   1 
ATOM   1063 C CB  . PHE   A 1 154 ? 13.80616  8.52936   17.09259  1.000 12.90084 ? 151 PHE   A CB  1 
ATOM   1064 C CG  . PHE   A 1 154 ? 13.92717  7.19654   17.78714  1.000 12.99907 ? 151 PHE   A CG  1 
ATOM   1065 C CD1 . PHE   A 1 154 ? 13.28808  6.07615   17.29346  1.000 17.49316 ? 151 PHE   A CD1 1 
ATOM   1066 C CD2 . PHE   A 1 154 ? 14.73933  7.06162   18.90074  1.000 25.04671 ? 151 PHE   A CD2 1 
ATOM   1067 C CE1 . PHE   A 1 154 ? 13.43133  4.83690   17.91325  1.000 18.59622 ? 151 PHE   A CE1 1 
ATOM   1068 C CE2 . PHE   A 1 154 ? 14.88165  5.82844   19.53224  1.000 24.45545 ? 151 PHE   A CE2 1 
ATOM   1069 C CZ  . PHE   A 1 154 ? 14.21824  4.72511   19.04037  1.000 20.09463 ? 151 PHE   A CZ  1 
ATOM   1070 N N   . THR   A 1 155 ? 12.53308  11.60261  17.53939  1.000 13.83837 ? 152 THR   A N   1 
ATOM   1071 C CA  . THR   A 1 155 ? 12.78937  12.99882  17.16961  1.000 13.30154 ? 152 THR   A CA  1 
ATOM   1072 C C   . THR   A 1 155 ? 13.70079  13.64273  18.20606  1.000 13.58601 ? 152 THR   A C   1 
ATOM   1073 O O   . THR   A 1 155 ? 14.08759  13.02384  19.20339  1.000 15.40366 ? 152 THR   A O   1 
ATOM   1074 C CB  . THR   A 1 155 ? 11.51436  13.85072  17.09112  1.000 15.75413 ? 152 THR   A CB  1 
ATOM   1075 O OG1 . THR   A 1 155 ? 11.02774  14.07639  18.42214  1.000 15.27609 ? 152 THR   A OG1 1 
ATOM   1076 C CG2 . THR   A 1 155 ? 10.43732  13.20517  16.20650  1.000 14.92185 ? 152 THR   A CG2 1 
ATOM   1077 N N   . ASP   A 1 156 ? 14.00061  14.92836  17.98460  1.000 18.65204 ? 153 ASP   A N   1 
ATOM   1078 C CA  . ASP   A 1 156 ? 14.76692  15.70313  18.95527  1.000 16.63349 ? 153 ASP   A CA  1 
ATOM   1079 C C   . ASP   A 1 156 ? 14.05730  15.81779  20.29454  1.000 17.88859 ? 153 ASP   A C   1 
ATOM   1080 O O   . ASP   A 1 156 ? 14.70967  16.08506  21.30877  1.000 20.47651 ? 153 ASP   A O   1 
ATOM   1081 C CB  . ASP   A 1 156 ? 15.03125  17.12033  18.43679  1.000 22.16616 ? 153 ASP   A CB  1 
ATOM   1082 C CG  . ASP   A 1 156 ? 15.97751  17.15539  17.25813  1.000 32.66784 ? 153 ASP   A CG  1 
ATOM   1083 O OD1 . ASP   A 1 156 ? 16.58642  16.11626  16.93095  1.000 34.48800 ? 153 ASP   A OD1 1 
ATOM   1084 O OD2 . ASP   A 1 156 ? 16.10403  18.24584  16.65974  1.000 30.89406 ? 153 ASP   A OD2 1 
ATOM   1085 N N   . SER   A 1 157 ? 12.73602  15.64623  20.31362  1.000 15.67085 ? 154 SER   A N   1 
ATOM   1086 C CA  . SER   A 1 157 ? 11.96866  15.77071  21.54671  1.000 15.73400 ? 154 SER   A CA  1 
ATOM   1087 C C   . SER   A 1 157 ? 12.05678  14.52218  22.41181  1.000 14.99807 ? 154 SER   A C   1 
ATOM   1088 O O   . SER   A 1 157 ? 11.94049  14.61464  23.63872  1.000 18.88062 ? 154 SER   A O   1 
ATOM   1089 C CB  . SER   A 1 157 ? 10.49766  16.05622  21.22411  1.000 21.49540 ? 154 SER   A CB  1 
ATOM   1090 O OG  . SER   A 1 157 ? 10.33175  17.31326  20.58969  1.000 21.98736 ? 154 SER   A OG  1 
ATOM   1091 N N   . GLY   A 1 158 ? 12.23689  13.36320  21.80655  1.000 14.95545 ? 155 GLY   A N   1 
ATOM   1092 C CA  . GLY   A 1 158 ? 12.24528  12.10732  22.53650  1.000 15.90193 ? 155 GLY   A CA  1 
ATOM   1093 C C   . GLY   A 1 158 ? 11.75044  10.99236  21.62647  1.000 14.01860 ? 155 GLY   A C   1 
ATOM   1094 O O   . GLY   A 1 158 ? 12.00427  11.02087  20.42023  1.000 13.73706 ? 155 GLY   A O   1 
ATOM   1095 N N   . ILE   A 1 159 ? 11.02708  10.03387  22.20842  1.000 12.31909 ? 156 ILE   A N   1 
ATOM   1096 C CA  . ILE   A 1 159 ? 10.47743  8.90754   21.45494  1.000 11.85353 ? 156 ILE   A CA  1 
ATOM   1097 C C   . ILE   A 1 159 ? 8.95455   8.95637   21.54247  1.000 13.15752 ? 156 ILE   A C   1 
ATOM   1098 O O   . ILE   A 1 159 ? 8.39591   9.22529   22.61293  1.000 12.22351 ? 156 ILE   A O   1 
ATOM   1099 C CB  . ILE   A 1 159 ? 11.02069  7.56351   21.97042  1.000 12.87414 ? 156 ILE   A CB  1 
ATOM   1100 C CG1 . ILE   A 1 159 ? 12.54092  7.63413   22.10459  1.000 14.47903 ? 156 ILE   A CG1 1 
ATOM   1101 C CG2 . ILE   A 1 159 ? 10.65548  6.41478   21.00943  1.000 13.68327 ? 156 ILE   A CG2 1 
ATOM   1102 C CD1 . ILE   A 1 159 ? 13.17872  6.35104   22.60475  1.000 15.54371 ? 156 ILE   A CD1 1 
ATOM   1103 N N   . HIS   A 1 160 ? 8.29153   8.69632   20.41477  1.000 11.80374 ? 157 HIS   A N   1 
ATOM   1104 C CA  . HIS   A 1 160 ? 6.84969   8.91835   20.26195  1.000 11.57049 ? 157 HIS   A CA  1 
ATOM   1105 C C   . HIS   A 1 160 ? 6.12909   7.63181   19.87430  1.000 12.04114 ? 157 HIS   A C   1 
ATOM   1106 O O   . HIS   A 1 160 ? 6.63824   6.83930   19.07593  1.000 12.71291 ? 157 HIS   A O   1 
ATOM   1107 C CB  . HIS   A 1 160 ? 6.53721   9.93374   19.14603  1.000 12.68703 ? 157 HIS   A CB  1 
ATOM   1108 C CG  . HIS   A 1 160 ? 7.27384   11.23603  19.24803  1.000 10.56778 ? 157 HIS   A CG  1 
ATOM   1109 N ND1 . HIS   A 1 160 ? 6.64744   12.41150  19.60181  1.000 12.34832 ? 157 HIS   A ND1 1 
ATOM   1110 C CD2 . HIS   A 1 160 ? 8.56483   11.56308  18.98386  1.000 13.71650 ? 157 HIS   A CD2 1 
ATOM   1111 C CE1 . HIS   A 1 160 ? 7.52395   13.40244  19.58508  1.000 13.20761 ? 157 HIS   A CE1 1 
ATOM   1112 N NE2 . HIS   A 1 160 ? 8.69587   12.91562  19.21755  1.000 13.73211 ? 157 HIS   A NE2 1 
ATOM   1113 N N   . ILE   A 1 161 ? 4.91066   7.46830   20.38935  1.000 11.16702 ? 158 ILE   A N   1 
ATOM   1114 C CA  . ILE   A 1 161 ? 3.88824   6.60545   19.79659  1.000 11.13673 ? 158 ILE   A CA  1 
ATOM   1115 C C   . ILE   A 1 161 ? 2.85280   7.52770   19.16876  1.000 10.17412 ? 158 ILE   A C   1 
ATOM   1116 O O   . ILE   A 1 161 ? 2.31722   8.41076   19.85097  1.000 12.29174 ? 158 ILE   A O   1 
ATOM   1117 C CB  . ILE   A 1 161 ? 3.22078   5.69159   20.83664  1.000 11.95731 ? 158 ILE   A CB  1 
ATOM   1118 C CG1 . ILE   A 1 161 ? 4.26485   4.84240   21.55820  1.000 13.49226 ? 158 ILE   A CG1 1 
ATOM   1119 C CG2 . ILE   A 1 161 ? 2.17920   4.78090   20.18286  1.000 13.61038 ? 158 ILE   A CG2 1 
ATOM   1120 C CD1 . ILE   A 1 161 ? 3.74328   4.19098   22.82705  1.000 15.43780 ? 158 ILE   A CD1 1 
ATOM   1121 N N   . ILE   A 1 162 ? 2.57471   7.33630   17.88522  1.000 11.28630 ? 159 ILE   A N   1 
ATOM   1122 C CA  . ILE   A 1 162 ? 1.68623   8.21604   17.12633  1.000 11.31120 ? 159 ILE   A CA  1 
ATOM   1123 C C   . ILE   A 1 162 ? 0.41778   7.44608   16.77082  1.000 11.44453 ? 159 ILE   A C   1 
ATOM   1124 O O   . ILE   A 1 162 ? 0.48875   6.31109   16.28889  1.000 11.95215 ? 159 ILE   A O   1 
ATOM   1125 C CB  . ILE   A 1 162 ? 2.35877   8.73334   15.84774  1.000 11.33618 ? 159 ILE   A CB  1 
ATOM   1126 C CG1 . ILE   A 1 162 ? 3.71726   9.36921   16.16639  1.000 11.78485 ? 159 ILE   A CG1 1 
ATOM   1127 C CG2 . ILE   A 1 162 ? 1.41654   9.71319   15.12834  1.000 12.08763 ? 159 ILE   A CG2 1 
ATOM   1128 C CD1 . ILE   A 1 162 ? 4.52740   9.71576   14.89800  1.000 14.38296 ? 159 ILE   A CD1 1 
ATOM   1129 N N   . LEU   A 1 163 ? -0.73923  8.06489   16.98393  1.000 11.60429 ? 160 LEU   A N   1 
ATOM   1130 C CA  . LEU   A 1 163 ? -2.01704  7.46764   16.61310  1.000 13.07480 ? 160 LEU   A CA  1 
ATOM   1131 C C   . LEU   A 1 163 ? -2.72522  8.43825   15.67967  1.000 10.58378 ? 160 LEU   A C   1 
ATOM   1132 O O   . LEU   A 1 163 ? -3.03620  9.56790   16.07136  1.000 13.49221 ? 160 LEU   A O   1 
ATOM   1133 C CB  . LEU   A 1 163 ? -2.86483  7.16714   17.85601  1.000 12.72115 ? 160 LEU   A CB  1 
ATOM   1134 C CG  . LEU   A 1 163 ? -4.29204  6.66963   17.59389  1.000 15.61318 ? 160 LEU   A CG  1 
ATOM   1135 C CD1 . LEU   A 1 163 ? -4.29219  5.32684   16.89486  1.000 18.31019 ? 160 LEU   A CD1 1 
ATOM   1136 C CD2 . LEU   A 1 163 ? -5.04747  6.54722   18.91126  1.000 20.56158 ? 160 LEU   A CD2 1 
ATOM   1137 N N   . ARG   A 1 164 ? -2.92937  8.03351   14.43374  1.000 12.30886 ? 161 ARG   A N   1 
ATOM   1138 C CA  . ARG   A 1 164 ? -3.60729  8.93039   13.49966  1.000 12.27508 ? 161 ARG   A CA  1 
ATOM   1139 C C   . ARG   A 1 164 ? -5.11292  8.84559   13.69742  1.000 15.85206 ? 161 ARG   A C   1 
ATOM   1140 O O   . ARG   A 1 164 ? -5.68473  7.74914   13.73853  1.000 15.46524 ? 161 ARG   A O   1 
ATOM   1141 C CB  . ARG   A 1 164 ? -3.24470  8.62197   12.04891  1.000 14.27070 ? 161 ARG   A CB  1 
ATOM   1142 C CG  . ARG   A 1 164 ? -3.98929  9.54657   11.08652  1.000 14.09746 ? 161 ARG   A CG  1 
ATOM   1143 C CD  . ARG   A 1 164 ? -3.55253  9.40685   9.62791   1.000 14.29952 ? 161 ARG   A CD  1 
ATOM   1144 N NE  . ARG   A 1 164 ? -4.48420  10.14674  8.77735   1.000 15.31131 ? 161 ARG   A NE  1 
ATOM   1145 C CZ  . ARG   A 1 164 ? -4.70280  9.89887   7.49343   1.000 18.68255 ? 161 ARG   A CZ  1 
ATOM   1146 N NH1 . ARG   A 1 164 ? -4.00252  8.98746   6.83314   1.000 17.85315 ? 161 ARG   A NH1 1 
ATOM   1147 N NH2 . ARG   A 1 164 ? -5.66084  10.57429  6.85945   1.000 17.84110 ? 161 ARG   A NH2 1 
ATOM   1148 N N   . THR   A 1 165 ? -5.75529  10.00011  13.83841  1.000 12.77267 ? 162 THR   A N   1 
ATOM   1149 C CA  . THR   A 1 165 ? -7.19233  10.01566  14.10823  1.000 15.09475 ? 162 THR   A CA  1 
ATOM   1150 C C   . THR   A 1 165 ? -8.02363  10.51876  12.93881  1.000 18.95942 ? 162 THR   A C   1 
ATOM   1151 O O   . THR   A 1 165 ? -9.16830  10.08449  12.78710  1.000 22.40503 ? 162 THR   A O   1 
ATOM   1152 C CB  . THR   A 1 165 ? -7.51318  10.86473  15.34857  1.000 15.34275 ? 162 THR   A CB  1 
ATOM   1153 O OG1 . THR   A 1 165 ? -6.99975  12.19002  15.19053  1.000 15.72269 ? 162 THR   A OG1 1 
ATOM   1154 C CG2 . THR   A 1 165 ? -6.91488  10.23474  16.61990  1.000 15.37246 ? 162 THR   A CG2 1 
ATOM   1155 N N   A GLU   A 1 166 ? -7.48597  11.42733  12.13066  0.530 15.24080 ? 163 GLU   A N   1 
ATOM   1156 N N   B GLU   A 1 166 ? -7.49339  11.41119  12.10777  0.470 15.25740 ? 163 GLU   A N   1 
ATOM   1157 C CA  A GLU   A 1 166 ? -8.15909  11.90822  10.92722  0.530 17.05676 ? 163 GLU   A CA  1 
ATOM   1158 C CA  B GLU   A 1 166 ? -8.19935  11.83161  10.89388  0.470 17.04772 ? 163 GLU   A CA  1 
ATOM   1159 C C   A GLU   A 1 166 ? -7.14467  12.02919  9.78996   0.530 16.04967 ? 163 GLU   A C   1 
ATOM   1160 C C   B GLU   A 1 166 ? -7.22259  12.03001  9.73373   0.470 16.05052 ? 163 GLU   A C   1 
ATOM   1161 O O   A GLU   A 1 166 ? -5.95790  12.27121  10.03168  0.530 7.73304  ? 163 GLU   A O   1 
ATOM   1162 O O   B GLU   A 1 166 ? -7.61953  12.06833  8.56863   0.470 9.15953  ? 163 GLU   A O   1 
ATOM   1163 C CB  A GLU   A 1 166 ? -8.84585  13.25700  11.18517  0.530 20.12600 ? 163 GLU   A CB  1 
ATOM   1164 C CB  B GLU   A 1 166 ? -9.00127  13.11836  11.13997  0.470 20.06670 ? 163 GLU   A CB  1 
ATOM   1165 C CG  A GLU   A 1 166 ? -9.76494  13.24571  12.40320  0.530 19.75541 ? 163 GLU   A CG  1 
ATOM   1166 C CG  B GLU   A 1 166 ? -10.10256 12.96258  12.18437  0.470 22.26731 ? 163 GLU   A CG  1 
ATOM   1167 C CD  A GLU   A 1 166 ? -10.34782 14.60321  12.73933  0.530 23.54323 ? 163 GLU   A CD  1 
ATOM   1168 C CD  B GLU   A 1 166 ? -11.01379 14.16962  12.29857  0.470 27.19507 ? 163 GLU   A CD  1 
ATOM   1169 O OE1 A GLU   A 1 166 ? -10.17174 15.55184  11.94345  0.530 26.53387 ? 163 GLU   A OE1 1 
ATOM   1170 O OE1 B GLU   A 1 166 ? -10.89035 15.10211  11.47729  0.470 26.89380 ? 163 GLU   A OE1 1 
ATOM   1171 O OE2 A GLU   A 1 166 ? -10.98966 14.71440  13.80659  0.530 22.21086 ? 163 GLU   A OE2 1 
ATOM   1172 O OE2 B GLU   A 1 166 ? -11.85696 14.18054  13.22137  0.470 30.24767 ? 163 GLU   A OE2 1 
ATOM   1173 N N   . LEU   B 1 10  ? 40.66911  12.03514  20.34492  1.000 46.50913 ? 7   LEU   B N   1 
ATOM   1174 C CA  . LEU   B 1 10  ? 40.25944  11.24030  19.19260  1.000 39.61216 ? 7   LEU   B CA  1 
ATOM   1175 C C   . LEU   B 1 10  ? 38.74834  11.29267  18.97931  1.000 41.35949 ? 7   LEU   B C   1 
ATOM   1176 O O   . LEU   B 1 10  ? 37.98366  11.31208  19.94034  1.000 39.09500 ? 7   LEU   B O   1 
ATOM   1177 C CB  . LEU   B 1 10  ? 40.70900  9.78484   19.35459  1.000 46.38066 ? 7   LEU   B CB  1 
ATOM   1178 C CG  . LEU   B 1 10  ? 42.19310  9.47687   19.14639  1.000 43.37132 ? 7   LEU   B CG  1 
ATOM   1179 C CD1 . LEU   B 1 10  ? 42.45384  7.98293   19.27546  1.000 41.35337 ? 7   LEU   B CD1 1 
ATOM   1180 C CD2 . LEU   B 1 10  ? 42.66385  9.99461   17.79727  1.000 46.50866 ? 7   LEU   B CD2 1 
ATOM   1181 N N   . PRO   B 1 11  ? 38.32813  11.30800  17.71660  1.000 43.40782 ? 8   PRO   B N   1 
ATOM   1182 C CA  . PRO   B 1 11  ? 36.89152  11.32731  17.39600  1.000 43.83878 ? 8   PRO   B CA  1 
ATOM   1183 C C   . PRO   B 1 11  ? 36.17803  10.12416  17.98680  1.000 41.29010 ? 8   PRO   B C   1 
ATOM   1184 O O   . PRO   B 1 11  ? 36.82325  9.13080   18.35748  1.000 41.61588 ? 8   PRO   B O   1 
ATOM   1185 C CB  . PRO   B 1 11  ? 36.87807  11.28859  15.85932  1.000 44.85296 ? 8   PRO   B CB  1 
ATOM   1186 C CG  . PRO   B 1 11  ? 38.19228  11.88416  15.46198  1.000 46.14541 ? 8   PRO   B CG  1 
ATOM   1187 C CD  . PRO   B 1 11  ? 39.16660  11.42606  16.51079  1.000 44.65050 ? 8   PRO   B CD  1 
ATOM   1188 N N   . PRO   B 1 12  ? 34.84856  10.17355  18.08573  1.000 44.81321 ? 9   PRO   B N   1 
ATOM   1189 C CA  . PRO   B 1 12  ? 34.11007  9.10728   18.77616  1.000 42.95224 ? 9   PRO   B CA  1 
ATOM   1190 C C   . PRO   B 1 12  ? 34.40418  7.71791   18.22974  1.000 36.28540 ? 9   PRO   B C   1 
ATOM   1191 O O   . PRO   B 1 12  ? 34.26469  7.45100   17.03137  1.000 36.08770 ? 9   PRO   B O   1 
ATOM   1192 C CB  . PRO   B 1 12  ? 32.64528  9.49652   18.54873  1.000 43.85737 ? 9   PRO   B CB  1 
ATOM   1193 C CG  . PRO   B 1 12  ? 32.67436  10.97616  18.41872  1.000 43.53029 ? 9   PRO   B CG  1 
ATOM   1194 C CD  . PRO   B 1 12  ? 33.97365  11.30699  17.73043  1.000 41.78540 ? 9   PRO   B CD  1 
ATOM   1195 N N   . GLY   B 1 13  ? 34.80618  6.82396   19.13221  1.000 38.22582 ? 10  GLY   B N   1 
ATOM   1196 C CA  . GLY   B 1 13  ? 34.95736  5.41877   18.83208  1.000 33.50102 ? 10  GLY   B CA  1 
ATOM   1197 C C   . GLY   B 1 13  ? 36.36339  4.97726   18.48987  1.000 23.94489 ? 10  GLY   B C   1 
ATOM   1198 O O   . GLY   B 1 13  ? 36.60619  3.76897   18.40897  1.000 23.39055 ? 10  GLY   B O   1 
ATOM   1199 N N   . TRP   B 1 14  ? 37.29384  5.91188   18.29772  1.000 32.75643 ? 11  TRP   B N   1 
ATOM   1200 C CA  . TRP   B 1 14  ? 38.63916  5.58938   17.83757  1.000 30.33014 ? 11  TRP   B CA  1 
ATOM   1201 C C   . TRP   B 1 14  ? 39.55069  5.22927   19.00989  1.000 31.76169 ? 11  TRP   B C   1 
ATOM   1202 O O   . TRP   B 1 14  ? 39.48487  5.84492   20.07822  1.000 36.18382 ? 11  TRP   B O   1 
ATOM   1203 C CB  . TRP   B 1 14  ? 39.22930  6.76616   17.05412  1.000 28.64707 ? 11  TRP   B CB  1 
ATOM   1204 C CG  . TRP   B 1 14  ? 38.70341  6.92388   15.63976  1.000 27.23035 ? 11  TRP   B CG  1 
ATOM   1205 C CD1 . TRP   B 1 14  ? 37.81541  7.86027   15.19105  1.000 25.73918 ? 11  TRP   B CD1 1 
ATOM   1206 C CD2 . TRP   B 1 14  ? 39.05581  6.13151   14.49702  1.000 27.51003 ? 11  TRP   B CD2 1 
ATOM   1207 N NE1 . TRP   B 1 14  ? 37.58895  7.69500   13.84812  1.000 29.77450 ? 11  TRP   B NE1 1 
ATOM   1208 C CE2 . TRP   B 1 14  ? 38.33355  6.63568   13.39800  1.000 24.12836 ? 11  TRP   B CE2 1 
ATOM   1209 C CE3 . TRP   B 1 14  ? 39.90072  5.03869   14.30105  1.000 21.65168 ? 11  TRP   B CE3 1 
ATOM   1210 C CZ2 . TRP   B 1 14  ? 38.44391  6.09500   12.11932  1.000 26.11866 ? 11  TRP   B CZ2 1 
ATOM   1211 C CZ3 . TRP   B 1 14  ? 40.00381  4.49825   13.03706  1.000 21.81034 ? 11  TRP   B CZ3 1 
ATOM   1212 C CH2 . TRP   B 1 14  ? 39.27478  5.02484   11.95822  1.000 23.84917 ? 11  TRP   B CH2 1 
ATOM   1213 N N   . GLU   B 1 15  ? 40.40245  4.22303   18.79903  1.000 24.47767 ? 12  GLU   B N   1 
ATOM   1214 C CA  . GLU   B 1 15  ? 41.37393  3.77995   19.79162  1.000 28.14642 ? 12  GLU   B CA  1 
ATOM   1215 C C   . GLU   B 1 15  ? 42.71030  3.51752   19.11154  1.000 28.30743 ? 12  GLU   B C   1 
ATOM   1216 O O   . GLU   B 1 15  ? 42.77774  3.26126   17.90905  1.000 26.52996 ? 12  GLU   B O   1 
ATOM   1217 C CB  . GLU   B 1 15  ? 40.91502  2.50582   20.51630  1.000 38.02107 ? 12  GLU   B CB  1 
ATOM   1218 C CG  . GLU   B 1 15  ? 39.89011  2.73675   21.60930  1.000 55.70703 ? 12  GLU   B CG  1 
ATOM   1219 C CD  . GLU   B 1 15  ? 39.03825  1.51095   21.87495  1.000 67.06026 ? 12  GLU   B CD  1 
ATOM   1220 O OE1 . GLU   B 1 15  ? 38.93466  0.64658   20.97686  1.000 56.80485 ? 12  GLU   B OE1 1 
ATOM   1221 O OE2 . GLU   B 1 15  ? 38.46778  1.41484   22.98145  1.000 79.87598 ? 12  GLU   B OE2 1 
ATOM   1222 N N   . LYS   B 1 16  ? 43.77703  3.57296   19.90569  1.000 32.96068 ? 13  LYS   B N   1 
ATOM   1223 C CA  . LYS   B 1 16  ? 45.11758  3.22734   19.44985  1.000 32.36202 ? 13  LYS   B CA  1 
ATOM   1224 C C   . LYS   B 1 16  ? 45.37921  1.73570   19.63514  1.000 29.12913 ? 13  LYS   B C   1 
ATOM   1225 O O   . LYS   B 1 16  ? 44.93784  1.13286   20.61675  1.000 37.14608 ? 13  LYS   B O   1 
ATOM   1226 C CB  . LYS   B 1 16  ? 46.15946  4.03890   20.22255  1.000 40.41097 ? 13  LYS   B CB  1 
ATOM   1227 C CG  . LYS   B 1 16  ? 47.00767  4.94653   19.35889  1.000 44.09539 ? 13  LYS   B CG  1 
ATOM   1228 C CD  . LYS   B 1 16  ? 47.68469  6.02174   20.19435  1.000 45.36895 ? 13  LYS   B CD  1 
ATOM   1229 C CE  . LYS   B 1 16  ? 49.11836  5.65565   20.53224  1.000 45.07696 ? 13  LYS   B CE  1 
ATOM   1230 N NZ  . LYS   B 1 16  ? 49.23906  4.36418   21.26404  1.000 50.01337 ? 13  LYS   B NZ  1 
ATOM   1231 N N   . ALA   B 1 17  ? 46.10352  1.14159   18.68622  1.000 27.86281 ? 14  ALA   B N   1 
ATOM   1232 C CA  . ALA   B 1 17  ? 46.45199  -0.27346  18.76021  1.000 32.74614 ? 14  ALA   B CA  1 
ATOM   1233 C C   . ALA   B 1 17  ? 47.81680  -0.48131  18.11553  1.000 28.09589 ? 14  ALA   B C   1 
ATOM   1234 O O   . ALA   B 1 17  ? 48.39251  0.43827   17.53148  1.000 28.78605 ? 14  ALA   B O   1 
ATOM   1235 C CB  . ALA   B 1 17  ? 45.39149  -1.14870  18.08317  1.000 35.29444 ? 14  ALA   B CB  1 
ATOM   1236 N N   . MET   B 1 18  ? 48.33030  -1.70858  18.21204  1.000 32.25979 ? 15  MET   B N   1 
ATOM   1237 C CA  . MET   B 1 18  ? 49.64124  -2.04448  17.66242  1.000 34.73311 ? 15  MET   B CA  1 
ATOM   1238 C C   . MET   B 1 18  ? 49.54384  -3.34866  16.88280  1.000 38.84450 ? 15  MET   B C   1 
ATOM   1239 O O   . MET   B 1 18  ? 49.11086  -4.36915  17.42631  1.000 36.81772 ? 15  MET   B O   1 
ATOM   1240 C CB  . MET   B 1 18  ? 50.69626  -2.14646  18.76934  1.000 41.23480 ? 15  MET   B CB  1 
ATOM   1241 C CG  . MET   B 1 18  ? 52.12917  -1.90338  18.28473  1.000 48.06336 ? 15  MET   B CG  1 
ATOM   1242 S SD  . MET   B 1 18  ? 53.36397  -1.81005  19.60524  1.000 80.18495 ? 15  MET   B SD  1 
ATOM   1243 C CE  . MET   B 1 18  ? 52.82954  -0.34336  20.48408  1.000 45.89475 ? 15  MET   B CE  1 
ATOM   1244 N N   . SER   B 1 19  ? 49.94295  -3.31092  15.61252  1.000 38.06070 ? 16  SER   B N   1 
ATOM   1245 C CA  . SER   B 1 19  ? 49.88774  -4.49151  14.76064  1.000 34.45913 ? 16  SER   B CA  1 
ATOM   1246 C C   . SER   B 1 19  ? 50.99592  -5.46989  15.12826  1.000 45.38124 ? 16  SER   B C   1 
ATOM   1247 O O   . SER   B 1 19  ? 52.15401  -5.07958  15.30251  1.000 46.88512 ? 16  SER   B O   1 
ATOM   1248 C CB  . SER   B 1 19  ? 50.00744  -4.08421  13.29358  1.000 33.49040 ? 16  SER   B CB  1 
ATOM   1249 O OG  . SER   B 1 19  ? 50.36598  -5.18818  12.47737  1.000 40.51992 ? 16  SER   B OG  1 
ATOM   1250 N N   . ARG   B 1 20  ? 50.63847  -6.74936  15.25003  1.000 37.37291 ? 17  ARG   B N   1 
ATOM   1251 C CA  . ARG   B 1 20  ? 51.61571  -7.77921  15.57332  1.000 38.72828 ? 17  ARG   B CA  1 
ATOM   1252 C C   . ARG   B 1 20  ? 52.28987  -8.35438  14.33843  1.000 37.08617 ? 17  ARG   B C   1 
ATOM   1253 O O   . ARG   B 1 20  ? 53.38326  -8.91684  14.45172  1.000 31.85469 ? 17  ARG   B O   1 
ATOM   1254 C CB  . ARG   B 1 20  ? 50.95322  -8.91475  16.36451  1.000 40.03147 ? 17  ARG   B CB  1 
ATOM   1255 C CG  . ARG   B 1 20  ? 50.14904  -8.43964  17.56476  1.000 45.10310 ? 17  ARG   B CG  1 
ATOM   1256 C CD  . ARG   B 1 20  ? 50.98106  -7.53140  18.45170  1.000 53.46116 ? 17  ARG   B CD  1 
ATOM   1257 N NE  . ARG   B 1 20  ? 50.15538  -6.73258  19.34915  1.000 59.25656 ? 17  ARG   B NE  1 
ATOM   1258 C CZ  . ARG   B 1 20  ? 49.82354  -7.09314  20.58075  1.000 53.74792 ? 17  ARG   B CZ  1 
ATOM   1259 N NH1 . ARG   B 1 20  ? 50.21711  -8.24725  21.09201  1.000 55.78958 ? 17  ARG   B NH1 1 
ATOM   1260 N NH2 . ARG   B 1 20  ? 49.07784  -6.27496  21.31793  1.000 58.47846 ? 17  ARG   B NH2 1 
ATOM   1261 N N   . SER   B 1 21  ? 51.67024  -8.22172  13.16780  1.000 29.91815 ? 18  SER   B N   1 
ATOM   1262 C CA  . SER   B 1 21  ? 52.26457  -8.73264  11.94241  1.000 32.11920 ? 18  SER   B CA  1 
ATOM   1263 C C   . SER   B 1 21  ? 53.29366  -7.78514  11.34420  1.000 37.87233 ? 18  SER   B C   1 
ATOM   1264 O O   . SER   B 1 21  ? 54.09148  -8.21935  10.50652  1.000 31.51545 ? 18  SER   B O   1 
ATOM   1265 C CB  . SER   B 1 21  ? 51.17671  -9.01503  10.90266  1.000 40.09101 ? 18  SER   B CB  1 
ATOM   1266 O OG  . SER   B 1 21  ? 51.75894  -9.37178  9.65907   1.000 42.13160 ? 18  SER   B OG  1 
ATOM   1267 N N   . SER   B 1 22  ? 53.29209  -6.50859  11.74716  1.000 29.99872 ? 19  SER   B N   1 
ATOM   1268 C CA  . SER   B 1 22  ? 54.23673  -5.54323  11.20188  1.000 35.43709 ? 19  SER   B CA  1 
ATOM   1269 C C   . SER   B 1 22  ? 54.90164  -4.66176  12.25049  1.000 32.58052 ? 19  SER   B C   1 
ATOM   1270 O O   . SER   B 1 22  ? 55.77935  -3.86919  11.88649  1.000 32.47431 ? 19  SER   B O   1 
ATOM   1271 C CB  . SER   B 1 22  ? 53.54440  -4.64341  10.16551  1.000 37.03872 ? 19  SER   B CB  1 
ATOM   1272 O OG  . SER   B 1 22  ? 52.54375  -3.85111  10.77880  1.000 32.19785 ? 19  SER   B OG  1 
ATOM   1273 N N   . GLY   B 1 23  ? 54.51772  -4.76227  13.52124  1.000 32.96170 ? 20  GLY   B N   1 
ATOM   1274 C CA  . GLY   B 1 23  ? 55.13207  -3.96118  14.56817  1.000 34.87484 ? 20  GLY   B CA  1 
ATOM   1275 C C   . GLY   B 1 23  ? 54.84870  -2.47818  14.47855  1.000 38.81170 ? 20  GLY   B C   1 
ATOM   1276 O O   . GLY   B 1 23  ? 55.70940  -1.66379  14.82903  1.000 33.60349 ? 20  GLY   B O   1 
ATOM   1277 N N   . ARG   B 1 24  ? 53.65786  -2.10062  14.03754  1.000 35.74916 ? 21  ARG   B N   1 
ATOM   1278 C CA  . ARG   B 1 24  ? 53.37368  -0.72195  13.67847  1.000 25.12355 ? 21  ARG   B CA  1 
ATOM   1279 C C   . ARG   B 1 24  ? 52.08332  -0.25979  14.34059  1.000 31.28948 ? 21  ARG   B C   1 
ATOM   1280 O O   . ARG   B 1 24  ? 51.11122  -1.01882  14.41897  1.000 33.18304 ? 21  ARG   B O   1 
ATOM   1281 C CB  . ARG   B 1 24  ? 53.27885  -0.60587  12.17114  1.000 25.69755 ? 21  ARG   B CB  1 
ATOM   1282 C CG  . ARG   B 1 24  ? 53.08244  0.77502   11.63954  1.000 22.20731 ? 21  ARG   B CG  1 
ATOM   1283 C CD  . ARG   B 1 24  ? 53.05941  0.67587   10.14692  1.000 22.36734 ? 21  ARG   B CD  1 
ATOM   1284 N NE  . ARG   B 1 24  ? 52.59518  1.89365   9.50580   1.000 24.00348 ? 21  ARG   B NE  1 
ATOM   1285 C CZ  . ARG   B 1 24  ? 52.28241  1.97782   8.22210   1.000 20.50889 ? 21  ARG   B CZ  1 
ATOM   1286 N NH1 . ARG   B 1 24  ? 52.35134  0.92232   7.42559   1.000 30.10735 ? 21  ARG   B NH1 1 
ATOM   1287 N NH2 . ARG   B 1 24  ? 51.89916  3.14644   7.72211   1.000 23.94651 ? 21  ARG   B NH2 1 
ATOM   1288 N N   . VAL   B 1 25  ? 52.08751  0.99070   14.81448  1.000 21.31084 ? 22  VAL   B N   1 
ATOM   1289 C CA  . VAL   B 1 25  ? 50.91299  1.59092   15.44525  1.000 26.88764 ? 22  VAL   B CA  1 
ATOM   1290 C C   . VAL   B 1 25  ? 49.82979  1.84575   14.40218  1.000 26.34860 ? 22  VAL   B C   1 
ATOM   1291 O O   . VAL   B 1 25  ? 50.11448  2.30739   13.28789  1.000 25.41970 ? 22  VAL   B O   1 
ATOM   1292 C CB  . VAL   B 1 25  ? 51.31069  2.90338   16.14902  1.000 21.99094 ? 22  VAL   B CB  1 
ATOM   1293 C CG1 . VAL   B 1 25  ? 50.07424  3.66415   16.64254  1.000 26.70656 ? 22  VAL   B CG1 1 
ATOM   1294 C CG2 . VAL   B 1 25  ? 52.28346  2.64063   17.29337  1.000 26.58283 ? 22  VAL   B CG2 1 
ATOM   1295 N N   . TYR   B 1 26  ? 48.56800  1.55876   14.76048  1.000 24.83469 ? 23  TYR   B N   1 
ATOM   1296 C CA  . TYR   B 1 26  ? 47.42276  1.90484   13.91682  1.000 23.74503 ? 23  TYR   B CA  1 
ATOM   1297 C C   . TYR   B 1 26  ? 46.25166  2.32211   14.80355  1.000 22.43808 ? 23  TYR   B C   1 
ATOM   1298 O O   . TYR   B 1 26  ? 46.33637  2.31399   16.03672  1.000 23.64419 ? 23  TYR   B O   1 
ATOM   1299 C CB  . TYR   B 1 26  ? 47.03640  0.75093   12.98005  1.000 27.11322 ? 23  TYR   B CB  1 
ATOM   1300 C CG  . TYR   B 1 26  ? 46.37828  -0.43675  13.65209  1.000 28.72263 ? 23  TYR   B CG  1 
ATOM   1301 C CD1 . TYR   B 1 26  ? 47.13876  -1.43375  14.25708  1.000 30.50516 ? 23  TYR   B CD1 1 
ATOM   1302 C CD2 . TYR   B 1 26  ? 44.99356  -0.57377  13.65631  1.000 30.65383 ? 23  TYR   B CD2 1 
ATOM   1303 C CE1 . TYR   B 1 26  ? 46.53305  -2.52881  14.86521  1.000 36.85934 ? 23  TYR   B CE1 1 
ATOM   1304 C CE2 . TYR   B 1 26  ? 44.38499  -1.65842  14.25924  1.000 31.78736 ? 23  TYR   B CE2 1 
ATOM   1305 C CZ  . TYR   B 1 26  ? 45.15454  -2.63052  14.86061  1.000 33.76676 ? 23  TYR   B CZ  1 
ATOM   1306 O OH  . TYR   B 1 26  ? 44.53747  -3.70802  15.45678  1.000 37.97569 ? 23  TYR   B OH  1 
ATOM   1307 N N   . TYR   B 1 27  ? 45.14666  2.70568   14.15969  1.000 24.01487 ? 24  TYR   B N   1 
ATOM   1308 C CA  . TYR   B 1 27  ? 43.96270  3.18775   14.85542  1.000 27.38535 ? 24  TYR   B CA  1 
ATOM   1309 C C   . TYR   B 1 27  ? 42.75459  2.36773   14.43346  1.000 21.20187 ? 24  TYR   B C   1 
ATOM   1310 O O   . TYR   B 1 27  ? 42.61522  2.00598   13.25978  1.000 22.72602 ? 24  TYR   B O   1 
ATOM   1311 C CB  . TYR   B 1 27  ? 43.71798  4.67154   14.57238  1.000 25.53634 ? 24  TYR   B CB  1 
ATOM   1312 C CG  . TYR   B 1 27  ? 44.89166  5.52441   14.97154  1.000 26.58374 ? 24  TYR   B CG  1 
ATOM   1313 C CD1 . TYR   B 1 27  ? 45.96121  5.70418   14.10450  1.000 29.47137 ? 24  TYR   B CD1 1 
ATOM   1314 C CD2 . TYR   B 1 27  ? 44.94419  6.12424   16.21974  1.000 31.16781 ? 24  TYR   B CD2 1 
ATOM   1315 C CE1 . TYR   B 1 27  ? 47.05350  6.46546   14.46727  1.000 33.98966 ? 24  TYR   B CE1 1 
ATOM   1316 C CE2 . TYR   B 1 27  ? 46.03727  6.89549   16.59159  1.000 36.75856 ? 24  TYR   B CE2 1 
ATOM   1317 C CZ  . TYR   B 1 27  ? 47.08275  7.06073   15.70724  1.000 38.62415 ? 24  TYR   B CZ  1 
ATOM   1318 O OH  . TYR   B 1 27  ? 48.17190  7.82300   16.06040  1.000 40.80974 ? 24  TYR   B OH  1 
ATOM   1319 N N   . PHE   B 1 28  ? 41.88750  2.08139   15.40474  1.000 23.06673 ? 25  PHE   B N   1 
ATOM   1320 C CA  . PHE   B 1 28  ? 40.71763  1.23752   15.21788  1.000 24.45456 ? 25  PHE   B CA  1 
ATOM   1321 C C   . PHE   B 1 28  ? 39.50142  1.93676   15.80911  1.000 23.50272 ? 25  PHE   B C   1 
ATOM   1322 O O   . PHE   B 1 28  ? 39.59395  2.57761   16.85824  1.000 23.55965 ? 25  PHE   B O   1 
ATOM   1323 C CB  . PHE   B 1 28  ? 40.92810  -0.12966  15.88224  1.000 23.93276 ? 25  PHE   B CB  1 
ATOM   1324 C CG  . PHE   B 1 28  ? 39.71092  -1.00105  15.87337  1.000 29.98891 ? 25  PHE   B CG  1 
ATOM   1325 C CD1 . PHE   B 1 28  ? 39.33853  -1.67742  14.72202  1.000 31.85397 ? 25  PHE   B CD1 1 
ATOM   1326 C CD2 . PHE   B 1 28  ? 38.94004  -1.14547  17.01673  1.000 28.31924 ? 25  PHE   B CD2 1 
ATOM   1327 C CE1 . PHE   B 1 28  ? 38.21152  -2.48023  14.70320  1.000 30.15355 ? 25  PHE   B CE1 1 
ATOM   1328 C CE2 . PHE   B 1 28  ? 37.80829  -1.94702  17.00841  1.000 32.50744 ? 25  PHE   B CE2 1 
ATOM   1329 C CZ  . PHE   B 1 28  ? 37.44597  -2.61705  15.85086  1.000 27.88970 ? 25  PHE   B CZ  1 
ATOM   1330 N N   . ASN   B 1 29  ? 38.36396  1.83606   15.12610  1.000 24.06838 ? 26  ASN   B N   1 
ATOM   1331 C CA  . ASN   B 1 29  ? 37.12670  2.44888   15.59348  1.000 21.73451 ? 26  ASN   B CA  1 
ATOM   1332 C C   . ASN   B 1 29  ? 36.16316  1.34151   15.98921  1.000 21.70021 ? 26  ASN   B C   1 
ATOM   1333 O O   . ASN   B 1 29  ? 35.79692  0.51672   15.15135  1.000 21.44081 ? 26  ASN   B O   1 
ATOM   1334 C CB  . ASN   B 1 29  ? 36.50696  3.33784   14.51667  1.000 22.02991 ? 26  ASN   B CB  1 
ATOM   1335 C CG  . ASN   B 1 29  ? 35.34171  4.14486   15.03684  1.000 23.85036 ? 26  ASN   B CG  1 
ATOM   1336 O OD1 . ASN   B 1 29  ? 34.33401  3.58784   15.48258  1.000 23.33923 ? 26  ASN   B OD1 1 
ATOM   1337 N ND2 . ASN   B 1 29  ? 35.46514  5.46076   14.97983  1.000 26.58743 ? 26  ASN   B ND2 1 
ATOM   1338 N N   . HIS   B 1 30  ? 35.74477  1.32672   17.25554  1.000 22.59420 ? 27  HIS   B N   1 
ATOM   1339 C CA  . HIS   B 1 30  ? 34.91227  0.21959   17.71060  1.000 25.35084 ? 27  HIS   B CA  1 
ATOM   1340 C C   . HIS   B 1 30  ? 33.44745  0.35813   17.30415  1.000 20.24222 ? 27  HIS   B C   1 
ATOM   1341 O O   . HIS   B 1 30  ? 32.72388  -0.64367  17.36194  1.000 25.34704 ? 27  HIS   B O   1 
ATOM   1342 C CB  . HIS   B 1 30  ? 35.03373  0.04507   19.23222  1.000 27.24248 ? 27  HIS   B CB  1 
ATOM   1343 C CG  . HIS   B 1 30  ? 34.36021  1.11509   20.03093  1.000 26.25312 ? 27  HIS   B CG  1 
ATOM   1344 N ND1 . HIS   B 1 30  ? 33.03421  1.04056   20.40214  1.000 32.06589 ? 27  HIS   B ND1 1 
ATOM   1345 C CD2 . HIS   B 1 30  ? 34.83020  2.27766   20.54415  1.000 34.36893 ? 27  HIS   B CD2 1 
ATOM   1346 C CE1 . HIS   B 1 30  ? 32.71346  2.11771   21.09585  1.000 29.78784 ? 27  HIS   B CE1 1 
ATOM   1347 N NE2 . HIS   B 1 30  ? 33.78494  2.88280   21.19955  1.000 31.42218 ? 27  HIS   B NE2 1 
ATOM   1348 N N   . ILE   B 1 31  ? 33.01102  1.54239   16.87084  1.000 23.51830 ? 28  ILE   B N   1 
ATOM   1349 C CA  . ILE   B 1 31  ? 31.63532  1.74263   16.40595  1.000 22.64895 ? 28  ILE   B CA  1 
ATOM   1350 C C   . ILE   B 1 31  ? 31.48918  1.38531   14.92788  1.000 25.01341 ? 28  ILE   B C   1 
ATOM   1351 O O   . ILE   B 1 31  ? 30.48511  0.79200   14.52390  1.000 24.87168 ? 28  ILE   B O   1 
ATOM   1352 C CB  . ILE   B 1 31  ? 31.19119  3.19545   16.66935  1.000 24.75670 ? 28  ILE   B CB  1 
ATOM   1353 C CG1 . ILE   B 1 31  ? 31.46980  3.60356   18.11988  1.000 22.07285 ? 28  ILE   B CG1 1 
ATOM   1354 C CG2 . ILE   B 1 31  ? 29.70359  3.36662   16.33899  1.000 21.92105 ? 28  ILE   B CG2 1 
ATOM   1355 C CD1 . ILE   B 1 31  ? 31.34797  5.08969   18.37551  1.000 26.87364 ? 28  ILE   B CD1 1 
ATOM   1356 N N   . THR   B 1 32  ? 32.47454  1.74872   14.09744  1.000 22.10509 ? 29  THR   B N   1 
ATOM   1357 C CA  . THR   B 1 32  ? 32.43196  1.45287   12.66613  1.000 21.57725 ? 29  THR   B CA  1 
ATOM   1358 C C   . THR   B 1 32  ? 33.22378  0.21638   12.28407  1.000 23.37907 ? 29  THR   B C   1 
ATOM   1359 O O   . THR   B 1 32  ? 33.04663  -0.29284  11.16729  1.000 20.16631 ? 29  THR   B O   1 
ATOM   1360 C CB  . THR   B 1 32  ? 32.99202  2.62052   11.85125  1.000 23.33482 ? 29  THR   B CB  1 
ATOM   1361 O OG1 . THR   B 1 32  ? 34.39708  2.74210   12.12933  1.000 20.59354 ? 29  THR   B OG1 1 
ATOM   1362 C CG2 . THR   B 1 32  ? 32.29200  3.91433   12.20135  1.000 20.61485 ? 29  THR   B CG2 1 
ATOM   1363 N N   . ASN   B 1 33  ? 34.10900  -0.24280  13.17500  1.000 20.56454 ? 30  ASN   B N   1 
ATOM   1364 C CA  . ASN   B 1 33  ? 35.01383  -1.37036  12.96701  1.000 21.07878 ? 30  ASN   B CA  1 
ATOM   1365 C C   . ASN   B 1 33  ? 36.03224  -1.10308  11.86617  1.000 17.94981 ? 30  ASN   B C   1 
ATOM   1366 O O   . ASN   B 1 33  ? 36.61317  -2.04021  11.31090  1.000 23.19003 ? 30  ASN   B O   1 
ATOM   1367 C CB  . ASN   B 1 33  ? 34.22755  -2.65492  12.72302  1.000 21.46406 ? 30  ASN   B CB  1 
ATOM   1368 C CG  . ASN   B 1 33  ? 33.34812  -2.99535  13.91172  1.000 25.01708 ? 30  ASN   B CG  1 
ATOM   1369 O OD1 . ASN   B 1 33  ? 33.71954  -2.71850  15.05317  1.000 27.26938 ? 30  ASN   B OD1 1 
ATOM   1370 N ND2 . ASN   B 1 33  ? 32.17252  -3.55092  13.65712  1.000 24.34181 ? 30  ASN   B ND2 1 
ATOM   1371 N N   . ALA   B 1 34  ? 36.26945  0.17403   11.58229  1.000 22.80508 ? 31  ALA   B N   1 
ATOM   1372 C CA  . ALA   B 1 34  ? 37.30556  0.58123   10.64793  1.000 22.00698 ? 31  ALA   B CA  1 
ATOM   1373 C C   . ALA   B 1 34  ? 38.67768  0.54405   11.31021  1.000 24.05393 ? 31  ALA   B C   1 
ATOM   1374 O O   . ALA   B 1 34  ? 38.81571  0.74870   12.51611  1.000 25.34918 ? 31  ALA   B O   1 
ATOM   1375 C CB  . ALA   B 1 34  ? 37.02431  1.98969   10.13018  1.000 22.08827 ? 31  ALA   B CB  1 
ATOM   1376 N N   . SER   B 1 35  ? 39.70238  0.29236   10.50217  1.000 22.83927 ? 32  SER   B N   1 
ATOM   1377 C CA  . SER   B 1 35  ? 41.07253  0.39170   10.98448  1.000 18.95048 ? 32  SER   B CA  1 
ATOM   1378 C C   . SER   B 1 35  ? 41.92058  1.03514   9.89789   1.000 27.95189 ? 32  SER   B C   1 
ATOM   1379 O O   . SER   B 1 35  ? 41.68405  0.81454   8.70614   1.000 27.15300 ? 32  SER   B O   1 
ATOM   1380 C CB  . SER   B 1 35  ? 41.61836  -0.98277  11.37777  1.000 27.79748 ? 32  SER   B CB  1 
ATOM   1381 O OG  . SER   B 1 35  ? 41.46000  -1.89990  10.31930  1.000 35.51851 ? 32  SER   B OG  1 
ATOM   1382 N N   . GLN   B 1 36  ? 42.90380  1.83047   10.31475  1.000 27.77306 ? 33  GLN   B N   1 
ATOM   1383 C CA  . GLN   B 1 36  ? 43.71401  2.59285   9.37345   1.000 28.39863 ? 33  GLN   B CA  1 
ATOM   1384 C C   . GLN   B 1 36  ? 45.03624  2.94948   10.03503  1.000 28.10269 ? 33  GLN   B C   1 
ATOM   1385 O O   . GLN   B 1 36  ? 45.14310  3.00635   11.26395  1.000 26.16192 ? 33  GLN   B O   1 
ATOM   1386 C CB  . GLN   B 1 36  ? 42.99879  3.86417   8.91249   1.000 29.66406 ? 33  GLN   B CB  1 
ATOM   1387 C CG  . GLN   B 1 36  ? 42.66301  4.79997   10.05553  1.000 26.31478 ? 33  GLN   B CG  1 
ATOM   1388 C CD  . GLN   B 1 36  ? 41.82960  5.98488   9.62211   1.000 31.73482 ? 33  GLN   B CD  1 
ATOM   1389 O OE1 . GLN   B 1 36  ? 40.83150  5.83351   8.91434   1.000 34.34458 ? 33  GLN   B OE1 1 
ATOM   1390 N NE2 . GLN   B 1 36  ? 42.22912  7.17305   10.04833  1.000 30.30280 ? 33  GLN   B NE2 1 
ATOM   1391 N N   . TRP   B 1 37  ? 46.04746  3.18624   9.19287   1.000 32.61386 ? 34  TRP   B N   1 
ATOM   1392 C CA  . TRP   B 1 37  ? 47.34401  3.62229   9.69831   1.000 32.99055 ? 34  TRP   B CA  1 
ATOM   1393 C C   . TRP   B 1 37  ? 47.29943  5.07715   10.13844  1.000 33.72944 ? 34  TRP   B C   1 
ATOM   1394 O O   . TRP   B 1 37  ? 47.96530  5.46391   11.10523  1.000 26.43713 ? 34  TRP   B O   1 
ATOM   1395 C CB  . TRP   B 1 37  ? 48.42178  3.44748   8.62774   1.000 24.95720 ? 34  TRP   B CB  1 
ATOM   1396 C CG  . TRP   B 1 37  ? 48.65998  2.04238   8.16234   1.000 27.62883 ? 34  TRP   B CG  1 
ATOM   1397 C CD1 . TRP   B 1 37  ? 48.53072  1.57008   6.89226   1.000 25.56601 ? 34  TRP   B CD1 1 
ATOM   1398 C CD2 . TRP   B 1 37  ? 49.08181  0.93383   8.96273   1.000 22.02466 ? 34  TRP   B CD2 1 
ATOM   1399 N NE1 . TRP   B 1 37  ? 48.83882  0.23071   6.85176   1.000 31.12529 ? 34  TRP   B NE1 1 
ATOM   1400 C CE2 . TRP   B 1 37  ? 49.18534  -0.18061  8.11100   1.000 23.45860 ? 34  TRP   B CE2 1 
ATOM   1401 C CE3 . TRP   B 1 37  ? 49.37767  0.77452   10.32197  1.000 22.29122 ? 34  TRP   B CE3 1 
ATOM   1402 C CZ2 . TRP   B 1 37  ? 49.57104  -1.43365  8.57153   1.000 29.13711 ? 34  TRP   B CZ2 1 
ATOM   1403 C CZ3 . TRP   B 1 37  ? 49.75902  -0.46245  10.77653  1.000 24.51562 ? 34  TRP   B CZ3 1 
ATOM   1404 C CH2 . TRP   B 1 37  ? 49.86111  -1.55490  9.90137   1.000 25.39068 ? 34  TRP   B CH2 1 
ATOM   1405 N N   . GLU   B 1 38  ? 46.52461  5.89487   9.43697   1.000 35.31250 ? 35  GLU   B N   1 
ATOM   1406 C CA  . GLU   B 1 38  ? 46.53541  7.33019   9.65216   1.000 28.05944 ? 35  GLU   B CA  1 
ATOM   1407 C C   . GLU   B 1 38  ? 45.72720  7.68444   10.89192  1.000 38.97520 ? 35  GLU   B C   1 
ATOM   1408 O O   . GLU   B 1 38  ? 44.65158  7.12654   11.13218  1.000 30.25607 ? 35  GLU   B O   1 
ATOM   1409 C CB  . GLU   B 1 38  ? 45.96859  8.05060   8.42577   1.000 32.73977 ? 35  GLU   B CB  1 
ATOM   1410 C CG  . GLU   B 1 38  ? 46.73049  7.79736   7.11749   1.000 41.70357 ? 35  GLU   B CG  1 
ATOM   1411 C CD  . GLU   B 1 38  ? 46.56806  6.38151   6.56152   1.000 46.96484 ? 35  GLU   B CD  1 
ATOM   1412 O OE1 . GLU   B 1 38  ? 45.56545  5.69989   6.87805   1.000 42.68824 ? 35  GLU   B OE1 1 
ATOM   1413 O OE2 . GLU   B 1 38  ? 47.46018  5.94488   5.80323   1.000 52.61909 ? 35  GLU   B OE2 1 
ATOM   1414 N N   . ARG   B 1 39  ? 46.24859  8.60985   11.68108  1.000 28.43787 ? 36  ARG   B N   1 
ATOM   1415 C CA  . ARG   B 1 39  ? 45.51129  9.07377   12.84510  1.000 28.63054 ? 36  ARG   B CA  1 
ATOM   1416 C C   . ARG   B 1 39  ? 44.28840  9.86268   12.39165  1.000 40.04989 ? 36  ARG   B C   1 
ATOM   1417 O O   . ARG   B 1 39  ? 44.41050  10.74571  11.53336  1.000 36.94385 ? 36  ARG   B O   1 
ATOM   1418 C CB  . ARG   B 1 39  ? 46.39428  9.93719   13.74395  1.000 39.49775 ? 36  ARG   B CB  1 
ATOM   1419 C CG  . ARG   B 1 39  ? 45.67712  10.47873  14.97538  1.000 40.33937 ? 36  ARG   B CG  1 
ATOM   1420 C CD  . ARG   B 1 39  ? 46.54190  11.48911  15.71260  1.000 43.97208 ? 36  ARG   B CD  1 
ATOM   1421 N NE  . ARG   B 1 39  ? 45.81593  12.16778  16.78085  1.000 49.99011 ? 36  ARG   B NE  1 
ATOM   1422 C CZ  . ARG   B 1 39  ? 45.78803  11.76681  18.04479  1.000 53.71290 ? 36  ARG   B CZ  1 
ATOM   1423 N NH1 . ARG   B 1 39  ? 46.43288  10.68028  18.44073  1.000 53.38626 ? 36  ARG   B NH1 1 
ATOM   1424 N NH2 . ARG   B 1 39  ? 45.09764  12.47500  18.93496  1.000 48.28697 ? 36  ARG   B NH2 1 
ATOM   1425 N N   . PRO   B 1 40  ? 43.10216  9.57038   12.92206  1.000 40.61721 ? 37  PRO   B N   1 
ATOM   1426 C CA  . PRO   B 1 40  ? 41.91570  10.34428  12.54220  1.000 43.01308 ? 37  PRO   B CA  1 
ATOM   1427 C C   . PRO   B 1 40  ? 41.92800  11.73485  13.15930  1.000 44.16146 ? 37  PRO   B C   1 
ATOM   1428 O O   . PRO   B 1 40  ? 42.40672  11.94430  14.27683  1.000 49.74485 ? 37  PRO   B O   1 
ATOM   1429 C CB  . PRO   B 1 40  ? 40.75698  9.50357   13.08924  1.000 35.32617 ? 37  PRO   B CB  1 
ATOM   1430 C CG  . PRO   B 1 40  ? 41.35180  8.76734   14.24240  1.000 37.20625 ? 37  PRO   B CG  1 
ATOM   1431 C CD  . PRO   B 1 40  ? 42.77973  8.48189   13.86211  1.000 34.62995 ? 37  PRO   B CD  1 
ATOM   1432 N N   . SER   B 1 41  ? 41.38721  12.69167  12.41145  1.000 47.74954 ? 38  SER   B N   1 
ATOM   1433 C CA  . SER   B 1 41  ? 41.31795  14.07958  12.86643  1.000 53.63315 ? 38  SER   B CA  1 
ATOM   1434 C C   . SER   B 1 41  ? 40.00377  14.36551  13.58661  1.000 51.55188 ? 38  SER   B C   1 
ATOM   1435 O O   . SER   B 1 41  ? 38.92264  14.15571  13.03436  1.000 58.38144 ? 38  SER   B O   1 
ATOM   1436 C CB  . SER   B 1 41  ? 41.49060  15.04079  11.68601  1.000 56.70577 ? 38  SER   B CB  1 
ATOM   1437 O OG  . SER   B 1 41  ? 40.61164  14.71320  10.62120  1.000 65.45163 ? 38  SER   B OG  1 
ATOM   1438 N N   . GLU   B 1 54  ? 26.35846  16.61750  15.69044  1.000 47.55965 ? 51  GLU   B N   1 
ATOM   1439 C CA  . GLU   B 1 54  ? 25.87002  15.51939  14.86009  1.000 41.35014 ? 51  GLU   B CA  1 
ATOM   1440 C C   . GLU   B 1 54  ? 24.72620  15.99355  13.97173  1.000 42.58443 ? 51  GLU   B C   1 
ATOM   1441 O O   . GLU   B 1 54  ? 23.78144  16.62373  14.44864  1.000 43.40636 ? 51  GLU   B O   1 
ATOM   1442 C CB  . GLU   B 1 54  ? 25.42382  14.33999  15.73463  1.000 43.13380 ? 51  GLU   B CB  1 
ATOM   1443 C CG  . GLU   B 1 54  ? 24.65980  13.24751  14.99018  1.000 38.48970 ? 51  GLU   B CG  1 
ATOM   1444 C CD  . GLU   B 1 54  ? 24.31073  12.05978  15.87574  1.000 36.59156 ? 51  GLU   B CD  1 
ATOM   1445 O OE1 . GLU   B 1 54  ? 25.23084  11.46406  16.47332  1.000 36.72868 ? 51  GLU   B OE1 1 
ATOM   1446 O OE2 . GLU   B 1 54  ? 23.11005  11.72545  15.97574  1.000 33.65831 ? 51  GLU   B OE2 1 
ATOM   1447 N N   . PRO   B 1 55  ? 24.81029  15.69828  12.67743  1.000 38.21241 ? 52  PRO   B N   1 
ATOM   1448 C CA  . PRO   B 1 55  ? 23.76807  16.15078  11.75052  1.000 35.05938 ? 52  PRO   B CA  1 
ATOM   1449 C C   . PRO   B 1 55  ? 22.44636  15.44079  12.00140  1.000 32.13663 ? 52  PRO   B C   1 
ATOM   1450 O O   . PRO   B 1 55  ? 22.38567  14.35462  12.58151  1.000 33.01413 ? 52  PRO   B O   1 
ATOM   1451 C CB  . PRO   B 1 55  ? 24.34024  15.79491  10.37326  1.000 28.90342 ? 52  PRO   B CB  1 
ATOM   1452 C CG  . PRO   B 1 55  ? 25.28767  14.67668  10.64143  1.000 30.83244 ? 52  PRO   B CG  1 
ATOM   1453 C CD  . PRO   B 1 55  ? 25.87410  14.94245  11.99470  1.000 39.98691 ? 52  PRO   B CD  1 
ATOM   1454 N N   . ALA   B 1 56  ? 21.36450  16.08542  11.55818  1.000 32.33230 ? 53  ALA   B N   1 
ATOM   1455 C CA  . ALA   B 1 56  ? 20.05173  15.46104  11.67962  1.000 30.44571 ? 53  ALA   B CA  1 
ATOM   1456 C C   . ALA   B 1 56  ? 19.97748  14.18570  10.85120  1.000 31.59675 ? 53  ALA   B C   1 
ATOM   1457 O O   . ALA   B 1 56  ? 19.38111  13.19121  11.28191  1.000 30.62557 ? 53  ALA   B O   1 
ATOM   1458 C CB  . ALA   B 1 56  ? 18.95634  16.44000  11.25814  1.000 38.60352 ? 53  ALA   B CB  1 
ATOM   1459 N N   . ARG   B 1 57  ? 20.59220  14.19269  9.66421   1.000 30.10951 ? 54  ARG   B N   1 
ATOM   1460 C CA  . ARG   B 1 57  ? 20.56620  13.06233  8.74539   1.000 23.51030 ? 54  ARG   B CA  1 
ATOM   1461 C C   . ARG   B 1 57  ? 21.97166  12.77878  8.22241   1.000 20.94127 ? 54  ARG   B C   1 
ATOM   1462 O O   . ARG   B 1 57  ? 22.83681  13.65610  8.17914   1.000 23.36074 ? 54  ARG   B O   1 
ATOM   1463 C CB  . ARG   B 1 57  ? 19.63725  13.31692  7.54715   1.000 28.58451 ? 54  ARG   B CB  1 
ATOM   1464 C CG  . ARG   B 1 57  ? 18.23824  13.81354  7.89251   1.000 37.21859 ? 54  ARG   B CG  1 
ATOM   1465 C CD  . ARG   B 1 57  ? 17.40620  14.08426  6.63931   1.000 33.98030 ? 54  ARG   B CD  1 
ATOM   1466 N NE  . ARG   B 1 57  ? 16.81667  12.87863  6.06709   1.000 40.41671 ? 54  ARG   B NE  1 
ATOM   1467 C CZ  . ARG   B 1 57  ? 15.80510  12.20732  6.60624   1.000 44.23530 ? 54  ARG   B CZ  1 
ATOM   1468 N NH1 . ARG   B 1 57  ? 15.28111  12.55815  7.77210   1.000 41.30825 ? 54  ARG   B NH1 1 
ATOM   1469 N NH2 . ARG   B 1 57  ? 15.30785  11.15328  5.96320   1.000 40.94015 ? 54  ARG   B NH2 1 
ATOM   1470 N N   . VAL   B 1 58  ? 22.18362  11.53021  7.80858   1.000 18.73039 ? 55  VAL   B N   1 
ATOM   1471 C CA  . VAL   B 1 58  ? 23.33860  11.14810  7.00291   1.000 19.27987 ? 55  VAL   B CA  1 
ATOM   1472 C C   . VAL   B 1 58  ? 22.81783  10.35568  5.81479   1.000 17.32844 ? 55  VAL   B C   1 
ATOM   1473 O O   . VAL   B 1 58  ? 21.70440  9.82858   5.83254   1.000 21.32399 ? 55  VAL   B O   1 
ATOM   1474 C CB  . VAL   B 1 58  ? 24.37793  10.31713  7.78522   1.000 17.73255 ? 55  VAL   B CB  1 
ATOM   1475 C CG1 . VAL   B 1 58  ? 24.95478  11.12889  8.95503   1.000 18.05568 ? 55  VAL   B CG1 1 
ATOM   1476 C CG2 . VAL   B 1 58  ? 23.75671  9.01680   8.28200   1.000 20.42815 ? 55  VAL   B CG2 1 
ATOM   1477 N N   . ARG   B 1 59  ? 23.64075  10.26440  4.77261   1.000 16.10268 ? 56  ARG   B N   1 
ATOM   1478 C CA  . ARG   B 1 59  ? 23.33078  9.41809   3.62866   1.000 18.48216 ? 56  ARG   B CA  1 
ATOM   1479 C C   . ARG   B 1 59  ? 24.41934  8.37152   3.50032   1.000 14.87813 ? 56  ARG   B C   1 
ATOM   1480 O O   . ARG   B 1 59  ? 25.60790  8.67999   3.64467   1.000 16.38121 ? 56  ARG   B O   1 
ATOM   1481 C CB  . ARG   B 1 59  ? 23.23163  10.22368  2.32735   1.000 17.31188 ? 56  ARG   B CB  1 
ATOM   1482 C CG  . ARG   B 1 59  ? 22.83589  9.41171   1.11745   1.000 17.17546 ? 56  ARG   B CG  1 
ATOM   1483 C CD  . ARG   B 1 59  ? 22.71628  10.32259  -0.10077  1.000 17.31618 ? 56  ARG   B CD  1 
ATOM   1484 N NE  . ARG   B 1 59  ? 22.25502  9.61278   -1.28762  1.000 19.82352 ? 56  ARG   B NE  1 
ATOM   1485 C CZ  . ARG   B 1 59  ? 22.11159  10.19169  -2.47369  1.000 25.71023 ? 56  ARG   B CZ  1 
ATOM   1486 N NH1 . ARG   B 1 59  ? 22.39093  11.47368  -2.65222  1.000 24.40738 ? 56  ARG   B NH1 1 
ATOM   1487 N NH2 . ARG   B 1 59  ? 21.67952  9.46894   -3.50358  1.000 26.08636 ? 56  ARG   B NH2 1 
ATOM   1488 N N   . CYS   B 1 60  ? 24.01965  7.13450   3.23620   1.000 15.51821 ? 57  CYS   B N   1 
ATOM   1489 C CA  . CYS   B 1 60  ? 24.98965  6.05646   3.10807   1.000 16.77038 ? 57  CYS   B CA  1 
ATOM   1490 C C   . CYS   B 1 60  ? 24.65012  5.14897   1.93946   1.000 16.50007 ? 57  CYS   B C   1 
ATOM   1491 O O   . CYS   B 1 60  ? 23.48902  5.01599   1.54228   1.000 19.89589 ? 57  CYS   B O   1 
ATOM   1492 C CB  . CYS   B 1 60  ? 25.06341  5.20826   4.38167   1.000 17.64312 ? 57  CYS   B CB  1 
ATOM   1493 S SG  . CYS   B 1 60  ? 25.64593  6.11313   5.79447   1.000 19.23331 ? 57  CYS   B SG  1 
ATOM   1494 N N   . SER   B 1 61  ? 25.69302  4.52190   1.40102   1.000 15.08005 ? 58  SER   B N   1 
ATOM   1495 C CA  . SER   B 1 61  ? 25.58786  3.34229   0.56602   1.000 14.57674 ? 58  SER   B CA  1 
ATOM   1496 C C   . SER   B 1 61  ? 26.09155  2.15460   1.36441   1.000 14.49610 ? 58  SER   B C   1 
ATOM   1497 O O   . SER   B 1 61  ? 26.81877  2.31909   2.34888   1.000 15.99911 ? 58  SER   B O   1 
ATOM   1498 C CB  . SER   B 1 61  ? 26.40781  3.49050   -0.71411  1.000 16.59419 ? 58  SER   B CB  1 
ATOM   1499 O OG  . SER   B 1 61  ? 25.84341  4.50478   -1.52138  1.000 18.50970 ? 58  SER   B OG  1 
ATOM   1500 N N   . HIS   B 1 62  ? 25.70618  0.95151   0.94604   1.000 15.69178 ? 59  HIS   B N   1 
ATOM   1501 C CA  . HIS   B 1 62  ? 26.23732  -0.21053  1.63942   1.000 14.15638 ? 59  HIS   B CA  1 
ATOM   1502 C C   . HIS   B 1 62  ? 26.29988  -1.41201  0.71262   1.000 15.90591 ? 59  HIS   B C   1 
ATOM   1503 O O   . HIS   B 1 62  ? 25.62174  -1.47899  -0.31906  1.000 17.33966 ? 59  HIS   B O   1 
ATOM   1504 C CB  . HIS   B 1 62  ? 25.43481  -0.55456  2.91434   1.000 15.10166 ? 59  HIS   B CB  1 
ATOM   1505 C CG  . HIS   B 1 62  ? 24.09510  -1.18651  2.66485   1.000 14.95305 ? 59  HIS   B CG  1 
ATOM   1506 N ND1 . HIS   B 1 62  ? 23.63517  -2.25894  3.40187   1.000 15.23929 ? 59  HIS   B ND1 1 
ATOM   1507 C CD2 . HIS   B 1 62  ? 23.10732  -0.88426  1.78892   1.000 24.97707 ? 59  HIS   B CD2 1 
ATOM   1508 C CE1 . HIS   B 1 62  ? 22.42790  -2.59610  2.98430   1.000 18.96679 ? 59  HIS   B CE1 1 
ATOM   1509 N NE2 . HIS   B 1 62  ? 22.08051  -1.77528  2.00800   1.000 21.32927 ? 59  HIS   B NE2 1 
ATOM   1510 N N   . LEU   B 1 63  ? 27.14192  -2.36084  1.10942   1.000 13.09694 ? 60  LEU   B N   1 
ATOM   1511 C CA  . LEU   B 1 63  ? 27.21033  -3.68621  0.50712   1.000 15.66584 ? 60  LEU   B CA  1 
ATOM   1512 C C   . LEU   B 1 63  ? 26.84249  -4.67336  1.60397   1.000 14.01062 ? 60  LEU   B C   1 
ATOM   1513 O O   . LEU   B 1 63  ? 27.49635  -4.71255  2.65161   1.000 15.72670 ? 60  LEU   B O   1 
ATOM   1514 C CB  . LEU   B 1 63  ? 28.60976  -3.96941  -0.06348  1.000 16.91883 ? 60  LEU   B CB  1 
ATOM   1515 C CG  . LEU   B 1 63  ? 28.83005  -5.20127  -0.95224  1.000 17.20145 ? 60  LEU   B CG  1 
ATOM   1516 C CD1 . LEU   B 1 63  ? 30.16825  -5.07923  -1.68709  1.000 17.79556 ? 60  LEU   B CD1 1 
ATOM   1517 C CD2 . LEU   B 1 63  ? 28.76840  -6.52233  -0.19428  1.000 17.70559 ? 60  LEU   B CD2 1 
ATOM   1518 N N   . LEU   B 1 64  ? 25.79289  -5.44896  1.37014   1.000 14.67971 ? 61  LEU   B N   1 
ATOM   1519 C CA  . LEU   B 1 64  ? 25.29844  -6.42006  2.33849   1.000 16.68388 ? 61  LEU   B CA  1 
ATOM   1520 C C   . LEU   B 1 64  ? 25.60289  -7.83070  1.86002   1.000 15.04826 ? 61  LEU   B C   1 
ATOM   1521 O O   . LEU   B 1 64  ? 25.25214  -8.19534  0.73396   1.000 16.26160 ? 61  LEU   B O   1 
ATOM   1522 C CB  . LEU   B 1 64  ? 23.78882  -6.26460  2.53959   1.000 15.91965 ? 61  LEU   B CB  1 
ATOM   1523 C CG  . LEU   B 1 64  ? 23.12551  -7.33985  3.40991   1.000 13.04541 ? 61  LEU   B CG  1 
ATOM   1524 C CD1 . LEU   B 1 64  ? 23.59002  -7.18883  4.84592   1.000 14.37451 ? 61  LEU   B CD1 1 
ATOM   1525 C CD2 . LEU   B 1 64  ? 21.60362  -7.22295  3.32444   1.000 17.69850 ? 61  LEU   B CD2 1 
ATOM   1526 N N   . VAL   B 1 65  ? 26.20846  -8.63611  2.72681   1.000 17.40731 ? 62  VAL   B N   1 
ATOM   1527 C CA  . VAL   B 1 65  ? 26.31896  -10.06887 2.50168   1.000 17.34169 ? 62  VAL   B CA  1 
ATOM   1528 C C   . VAL   B 1 65  ? 25.45744  -10.75223 3.55360   1.000 14.14537 ? 62  VAL   B C   1 
ATOM   1529 O O   . VAL   B 1 65  ? 25.73225  -10.65159 4.75527   1.000 17.04405 ? 62  VAL   B O   1 
ATOM   1530 C CB  . VAL   B 1 65  ? 27.77325  -10.55359 2.56599   1.000 16.29764 ? 62  VAL   B CB  1 
ATOM   1531 C CG1 . VAL   B 1 65  ? 27.84810  -12.05635 2.31062   1.000 17.72619 ? 62  VAL   B CG1 1 
ATOM   1532 C CG2 . VAL   B 1 65  ? 28.60195  -9.82921  1.52883   1.000 19.08560 ? 62  VAL   B CG2 1 
ATOM   1533 N N   . LYS   B 1 66  ? 24.39896  -11.41058 3.10144   1.000 15.55956 ? 63  LYS   B N   1 
ATOM   1534 C CA  . LYS   B 1 66  ? 23.49522  -12.11822 3.99612   1.000 16.87022 ? 63  LYS   B CA  1 
ATOM   1535 C C   . LYS   B 1 66  ? 24.04916  -13.49812 4.32549   1.000 20.62601 ? 63  LYS   B C   1 
ATOM   1536 O O   . LYS   B 1 66  ? 24.96782  -14.00466 3.67528   1.000 20.21266 ? 63  LYS   B O   1 
ATOM   1537 C CB  . LYS   B 1 66  ? 22.10989  -12.25280 3.36626   1.000 19.28495 ? 63  LYS   B CB  1 
ATOM   1538 C CG  . LYS   B 1 66  ? 21.35846  -10.93788 3.18105   1.000 17.52630 ? 63  LYS   B CG  1 
ATOM   1539 C CD  . LYS   B 1 66  ? 19.94998  -11.18335 2.64655   1.000 18.99540 ? 63  LYS   B CD  1 
ATOM   1540 C CE  . LYS   B 1 66  ? 19.18910  -9.86422  2.53570   1.000 20.75439 ? 63  LYS   B CE  1 
ATOM   1541 N NZ  . LYS   B 1 66  ? 17.79354  -10.05286 2.04567   1.000 25.85631 ? 63  LYS   B NZ  1 
ATOM   1542 N N   . HIS   B 1 67  ? 23.48684  -14.10883 5.36547   1.000 19.96191 ? 64  HIS   B N   1 
ATOM   1543 C CA  . HIS   B 1 67  ? 23.85123  -15.46648 5.74375   1.000 20.51660 ? 64  HIS   B CA  1 
ATOM   1544 C C   . HIS   B 1 67  ? 22.58985  -16.18774 6.19681   1.000 23.19273 ? 64  HIS   B C   1 
ATOM   1545 O O   . HIS   B 1 67  ? 21.48962  -15.62493 6.18333   1.000 20.86671 ? 64  HIS   B O   1 
ATOM   1546 C CB  . HIS   B 1 67  ? 24.94344  -15.47941 6.81816   1.000 21.10078 ? 64  HIS   B CB  1 
ATOM   1547 C CG  . HIS   B 1 67  ? 24.62440  -14.64354 8.01488   1.000 23.13892 ? 64  HIS   B CG  1 
ATOM   1548 N ND1 . HIS   B 1 67  ? 23.76461  -15.06434 9.00745   1.000 25.17865 ? 64  HIS   B ND1 1 
ATOM   1549 C CD2 . HIS   B 1 67  ? 25.03971  -13.40706 8.37479   1.000 25.79322 ? 64  HIS   B CD2 1 
ATOM   1550 C CE1 . HIS   B 1 67  ? 23.67075  -14.12420 9.93060   1.000 31.00809 ? 64  HIS   B CE1 1 
ATOM   1551 N NE2 . HIS   B 1 67  ? 24.43164  -13.10705 9.56878   1.000 24.61011 ? 64  HIS   B NE2 1 
ATOM   1552 N N   . SER   B 1 68  ? 22.74971  -17.46225 6.56882   1.000 22.97795 ? 65  SER   B N   1 
ATOM   1553 C CA  . SER   B 1 68  ? 21.59360  -18.31999 6.81551   1.000 20.35703 ? 65  SER   B CA  1 
ATOM   1554 C C   . SER   B 1 68  ? 20.74736  -17.86093 7.99217   1.000 23.55801 ? 65  SER   B C   1 
ATOM   1555 O O   . SER   B 1 68  ? 19.56744  -18.22238 8.06339   1.000 28.04752 ? 65  SER   B O   1 
ATOM   1556 C CB  . SER   B 1 68  ? 22.05194  -19.76101 7.05602   1.000 24.03491 ? 65  SER   B CB  1 
ATOM   1557 O OG  . SER   B 1 68  ? 22.86487  -19.84079 8.21806   1.000 27.08400 ? 65  SER   B OG  1 
ATOM   1558 N N   . GLN   B 1 69  ? 21.30720  -17.08377 8.91320   1.000 23.27631 ? 66  GLN   B N   1 
ATOM   1559 C CA  . GLN   B 1 69  ? 20.56973  -16.61811 10.07884  1.000 27.35769 ? 66  GLN   B CA  1 
ATOM   1560 C C   . GLN   B 1 69  ? 20.07145  -15.18642 9.92969   1.000 25.18262 ? 66  GLN   B C   1 
ATOM   1561 O O   . GLN   B 1 69  ? 19.59336  -14.60547 10.90952  1.000 24.03180 ? 66  GLN   B O   1 
ATOM   1562 C CB  . GLN   B 1 69  ? 21.43506  -16.74451 11.33221  1.000 28.42245 ? 66  GLN   B CB  1 
ATOM   1563 C CG  . GLN   B 1 69  ? 21.96658  -18.15647 11.56227  1.000 32.93086 ? 66  GLN   B CG  1 
ATOM   1564 C CD  . GLN   B 1 69  ? 22.85501  -18.24686 12.78319  1.000 43.60975 ? 66  GLN   B CD  1 
ATOM   1565 O OE1 . GLN   B 1 69  ? 24.08009  -18.14520 12.68521  1.000 44.71699 ? 66  GLN   B OE1 1 
ATOM   1566 N NE2 . GLN   B 1 69  ? 22.24200  -18.43923 13.94574  1.000 51.94785 ? 66  GLN   B NE2 1 
ATOM   1567 N N   . SER   B 1 70  ? 20.17390  -14.60988 8.73228   1.000 23.13005 ? 67  SER   B N   1 
ATOM   1568 C CA  . SER   B 1 70  ? 19.65541  -13.27737 8.46313   1.000 24.07515 ? 67  SER   B CA  1 
ATOM   1569 C C   . SER   B 1 70  ? 18.12734  -13.27539 8.46038   1.000 18.16101 ? 67  SER   B C   1 
ATOM   1570 O O   . SER   B 1 70  ? 17.48077  -14.28892 8.18884   1.000 22.72680 ? 67  SER   B O   1 
ATOM   1571 C CB  . SER   B 1 70  ? 20.17248  -12.76901 7.11708   1.000 23.29040 ? 67  SER   B CB  1 
ATOM   1572 O OG  . SER   B 1 70  ? 21.58675  -12.64882 7.15401   1.000 28.78058 ? 67  SER   B OG  1 
ATOM   1573 N N   . ARG   B 1 71  ? 17.56064  -12.09237 8.72568   1.000 19.05280 ? 68  ARG   B N   1 
ATOM   1574 C CA  . ARG   B 1 71  ? 16.10778  -11.93100 8.83312   1.000 20.58371 ? 68  ARG   B CA  1 
ATOM   1575 C C   . ARG   B 1 71  ? 15.37709  -12.37062 7.56878   1.000 27.69055 ? 68  ARG   B C   1 
ATOM   1576 O O   . ARG   B 1 71  ? 14.31561  -13.00353 7.63689   1.000 31.64289 ? 68  ARG   B O   1 
ATOM   1577 C CB  . ARG   B 1 71  ? 15.76416  -10.47296 9.13121   1.000 25.06125 ? 68  ARG   B CB  1 
ATOM   1578 C CG  . ARG   B 1 71  ? 15.64581  -10.13444 10.58933  1.000 30.94579 ? 68  ARG   B CG  1 
ATOM   1579 C CD  . ARG   B 1 71  ? 14.54015  -9.11931  10.79053  1.000 29.47632 ? 68  ARG   B CD  1 
ATOM   1580 N NE  . ARG   B 1 71  ? 14.81248  -7.86523  10.10110  1.000 38.63598 ? 68  ARG   B NE  1 
ATOM   1581 C CZ  . ARG   B 1 71  ? 15.20615  -6.75179  10.70531  1.000 35.63579 ? 68  ARG   B CZ  1 
ATOM   1582 N NH1 . ARG   B 1 71  ? 15.36156  -6.69613  12.01953  1.000 36.24209 ? 68  ARG   B NH1 1 
ATOM   1583 N NH2 . ARG   B 1 71  ? 15.43883  -5.66411  9.97450   1.000 33.31087 ? 68  ARG   B NH2 1 
ATOM   1584 N N   . ARG   B 1 72  ? 15.88787  -11.98826 6.40642   1.000 25.65351 ? 69  ARG   B N   1 
ATOM   1585 C CA  . ARG   B 1 72  ? 15.27573  -12.31382 5.12070   1.000 24.14924 ? 69  ARG   B CA  1 
ATOM   1586 C C   . ARG   B 1 72  ? 16.33983  -13.04790 4.31220   1.000 21.94307 ? 69  ARG   B C   1 
ATOM   1587 O O   . ARG   B 1 72  ? 17.06209  -12.43554 3.51274   1.000 23.24201 ? 69  ARG   B O   1 
ATOM   1588 C CB  . ARG   B 1 72  ? 14.77508  -11.05256 4.41799   1.000 22.78780 ? 69  ARG   B CB  1 
ATOM   1589 C CG  . ARG   B 1 72  ? 14.23364  -11.26322 3.00681   1.000 30.74746 ? 69  ARG   B CG  1 
ATOM   1590 C CD  . ARG   B 1 72  ? 13.95130  -9.92887  2.32009   1.000 34.49653 ? 69  ARG   B CD  1 
ATOM   1591 N NE  . ARG   B 1 72  ? 12.72583  -9.29701  2.79799   1.000 49.62249 ? 69  ARG   B NE  1 
ATOM   1592 C CZ  . ARG   B 1 72  ? 12.66735  -8.40381  3.77730   1.000 46.15039 ? 69  ARG   B CZ  1 
ATOM   1593 N NH1 . ARG   B 1 72  ? 13.75315  -8.01608  4.42721   1.000 46.74131 ? 69  ARG   B NH1 1 
ATOM   1594 N NH2 . ARG   B 1 72  ? 11.48782  -7.88836  4.11538   1.000 48.20765 ? 69  ARG   B NH2 1 
ATOM   1595 N N   . PRO   B 1 73  ? 16.47391  -14.36113 4.50327   1.000 19.83686 ? 70  PRO   B N   1 
ATOM   1596 C CA  . PRO   B 1 73  ? 17.57869  -15.12106 3.89266   1.000 18.13795 ? 70  PRO   B CA  1 
ATOM   1597 C C   . PRO   B 1 73  ? 17.31169  -15.46681 2.43049   1.000 19.66494 ? 70  PRO   B C   1 
ATOM   1598 O O   . PRO   B 1 73  ? 17.22898  -16.63683 2.03565   1.000 21.66918 ? 70  PRO   B O   1 
ATOM   1599 C CB  . PRO   B 1 73  ? 17.65440  -16.35882 4.79339   1.000 21.99153 ? 70  PRO   B CB  1 
ATOM   1600 C CG  . PRO   B 1 73  ? 16.23411  -16.57759 5.20027   1.000 20.50281 ? 70  PRO   B CG  1 
ATOM   1601 C CD  . PRO   B 1 73  ? 15.66554  -15.19797 5.41017   1.000 21.87998 ? 70  PRO   B CD  1 
ATOM   1602 N N   . SER   B 1 74  ? 17.14247  -14.42471 1.62236   1.000 21.11811 ? 71  SER   B N   1 
ATOM   1603 C CA  . SER   B 1 74  ? 16.98025  -14.52915 0.18037   1.000 18.60573 ? 71  SER   B CA  1 
ATOM   1604 C C   . SER   B 1 74  ? 17.44170  -13.21203 -0.41905  1.000 21.22321 ? 71  SER   B C   1 
ATOM   1605 O O   . SER   B 1 74  ? 17.51972  -12.19501 0.27026   1.000 23.21532 ? 71  SER   B O   1 
ATOM   1606 C CB  . SER   B 1 74  ? 15.53002  -14.81612 -0.21443  1.000 24.88969 ? 71  SER   B CB  1 
ATOM   1607 O OG  . SER   B 1 74  ? 14.69975  -13.72800 0.14615   1.000 31.48821 ? 71  SER   B OG  1 
ATOM   1608 N N   . SER   B 1 75  ? 17.74937  -13.23588 -1.71471  1.000 23.37521 ? 72  SER   B N   1 
ATOM   1609 C CA  . SER   B 1 75  ? 18.11306  -12.01104 -2.41532  1.000 20.31232 ? 72  SER   B CA  1 
ATOM   1610 C C   . SER   B 1 75  ? 17.92669  -12.24559 -3.90614  1.000 19.06973 ? 72  SER   B C   1 
ATOM   1611 O O   . SER   B 1 75  ? 17.60273  -13.35505 -4.34462  1.000 21.84860 ? 72  SER   B O   1 
ATOM   1612 C CB  . SER   B 1 75  ? 19.55203  -11.58550 -2.10603  1.000 23.81890 ? 72  SER   B CB  1 
ATOM   1613 O OG  . SER   B 1 75  ? 20.47403  -12.39810 -2.81137  1.000 23.69516 ? 72  SER   B OG  1 
ATOM   1614 N N   . TRP   B 1 76  ? 18.12336  -11.17832 -4.68676  1.000 22.32400 ? 73  TRP   B N   1 
ATOM   1615 C CA  . TRP   B 1 76  ? 18.09166  -11.32521 -6.14093  1.000 21.40581 ? 73  TRP   B CA  1 
ATOM   1616 C C   . TRP   B 1 76  ? 19.08352  -12.38055 -6.62514  1.000 20.84275 ? 73  TRP   B C   1 
ATOM   1617 O O   . TRP   B 1 76  ? 18.87338  -12.98525 -7.68260  1.000 21.66013 ? 73  TRP   B O   1 
ATOM   1618 C CB  . TRP   B 1 76  ? 18.37566  -9.97966  -6.81407  1.000 22.91717 ? 73  TRP   B CB  1 
ATOM   1619 C CG  . TRP   B 1 76  ? 19.76635  -9.44180  -6.55923  1.000 21.82229 ? 73  TRP   B CG  1 
ATOM   1620 C CD1 . TRP   B 1 76  ? 20.15985  -8.63295  -5.52222  1.000 23.41735 ? 73  TRP   B CD1 1 
ATOM   1621 C CD2 . TRP   B 1 76  ? 20.94281  -9.66896  -7.35289  1.000 23.70695 ? 73  TRP   B CD2 1 
ATOM   1622 N NE1 . TRP   B 1 76  ? 21.50492  -8.35330  -5.61943  1.000 21.55227 ? 73  TRP   B NE1 1 
ATOM   1623 C CE2 . TRP   B 1 76  ? 22.00755  -8.97494  -6.73285  1.000 21.25614 ? 73  TRP   B CE2 1 
ATOM   1624 C CE3 . TRP   B 1 76  ? 21.20145  -10.39601 -8.52420  1.000 23.33736 ? 73  TRP   B CE3 1 
ATOM   1625 C CZ2 . TRP   B 1 76  ? 23.30610  -8.98215  -7.24632  1.000 22.41519 ? 73  TRP   B CZ2 1 
ATOM   1626 C CZ3 . TRP   B 1 76  ? 22.49427  -10.40652 -9.02431  1.000 25.18612 ? 73  TRP   B CZ3 1 
ATOM   1627 C CH2 . TRP   B 1 76  ? 23.52587  -9.70045  -8.38765  1.000 22.34499 ? 73  TRP   B CH2 1 
ATOM   1628 N N   . ARG   B 1 77  ? 20.15123  -12.63652 -5.86006  1.000 19.28255 ? 74  ARG   B N   1 
ATOM   1629 C CA  . ARG   B 1 77  ? 21.18358  -13.58495 -6.27821  1.000 22.17074 ? 74  ARG   B CA  1 
ATOM   1630 C C   . ARG   B 1 77  ? 20.75277  -15.03227 -6.08044  1.000 24.50460 ? 74  ARG   B C   1 
ATOM   1631 O O   . ARG   B 1 77  ? 21.00161  -15.88080 -6.94670  1.000 23.64760 ? 74  ARG   B O   1 
ATOM   1632 C CB  . ARG   B 1 77  ? 22.48190  -13.34125 -5.50256  1.000 21.29186 ? 74  ARG   B CB  1 
ATOM   1633 C CG  . ARG   B 1 77  ? 23.07062  -11.94975 -5.64519  1.000 21.13909 ? 74  ARG   B CG  1 
ATOM   1634 C CD  . ARG   B 1 77  ? 24.44992  -11.86275 -5.00804  1.000 25.37053 ? 74  ARG   B CD  1 
ATOM   1635 N NE  . ARG   B 1 77  ? 25.45364  -12.60348 -5.76629  1.000 22.19800 ? 74  ARG   B NE  1 
ATOM   1636 C CZ  . ARG   B 1 77  ? 26.54108  -13.14451 -5.23877  1.000 24.88159 ? 74  ARG   B CZ  1 
ATOM   1637 N NH1 . ARG   B 1 77  ? 26.78865  -13.07716 -3.93937  1.000 27.42929 ? 74  ARG   B NH1 1 
ATOM   1638 N NH2 . ARG   B 1 77  ? 27.39454  -13.78768 -6.03160  1.000 27.35623 ? 74  ARG   B NH2 1 
ATOM   1639 N N   . GLN   B 1 78  ? 20.12782  -15.33157 -4.93955  1.000 25.59417 ? 75  GLN   B N   1 
ATOM   1640 C CA  . GLN   B 1 78  ? 19.78195  -16.68848 -4.54259  1.000 24.01899 ? 75  GLN   B CA  1 
ATOM   1641 C C   . GLN   B 1 78  ? 18.40416  -16.68759 -3.90878  1.000 27.63432 ? 75  GLN   B C   1 
ATOM   1642 O O   . GLN   B 1 78  ? 18.11917  -15.84631 -3.05309  1.000 25.90385 ? 75  GLN   B O   1 
ATOM   1643 C CB  . GLN   B 1 78  ? 20.76721  -17.26032 -3.51405  1.000 26.78434 ? 75  GLN   B CB  1 
ATOM   1644 C CG  . GLN   B 1 78  ? 22.20182  -17.41701 -3.96280  1.000 32.42795 ? 75  GLN   B CG  1 
ATOM   1645 C CD  . GLN   B 1 78  ? 23.07941  -17.89342 -2.82475  1.000 29.60820 ? 75  GLN   B CD  1 
ATOM   1646 O OE1 . GLN   B 1 78  ? 23.45024  -17.11470 -1.94924  1.000 26.64983 ? 75  GLN   B OE1 1 
ATOM   1647 N NE2 . GLN   B 1 78  ? 23.38900  -19.18834 -2.81190  1.000 32.14487 ? 75  GLN   B NE2 1 
ATOM   1648 N N   . GLU   B 1 79  ? 17.56882  -17.65937 -4.28785  1.000 27.91422 ? 76  GLU   B N   1 
ATOM   1649 C CA  . GLU   B 1 79  ? 16.25587  -17.75842 -3.65409  1.000 25.89586 ? 76  GLU   B CA  1 
ATOM   1650 C C   . GLU   B 1 79  ? 16.37042  -18.13491 -2.18006  1.000 27.28268 ? 76  GLU   B C   1 
ATOM   1651 O O   . GLU   B 1 79  ? 15.51237  -17.75038 -1.37636  1.000 27.21478 ? 76  GLU   B O   1 
ATOM   1652 C CB  . GLU   B 1 79  ? 15.37940  -18.76202 -4.40733  1.000 33.54354 ? 76  GLU   B CB  1 
ATOM   1653 C CG  . GLU   B 1 79  ? 15.19358  -18.40932 -5.87903  1.000 32.17808 ? 76  GLU   B CG  1 
ATOM   1654 C CD  . GLU   B 1 79  ? 14.05499  -19.16607 -6.52675  1.000 46.12712 ? 76  GLU   B CD  1 
ATOM   1655 O OE1 . GLU   B 1 79  ? 12.89538  -18.97036 -6.10426  1.000 46.55600 ? 76  GLU   B OE1 1 
ATOM   1656 O OE2 . GLU   B 1 79  ? 14.31928  -19.96103 -7.45530  1.000 44.06532 ? 76  GLU   B OE2 1 
ATOM   1657 N N   . LYS   B 1 80  ? 17.42149  -18.85991 -1.80401  1.000 24.62356 ? 77  LYS   B N   1 
ATOM   1658 C CA  . LYS   B 1 80  ? 17.66005  -19.23522 -0.41380  1.000 25.61325 ? 77  LYS   B CA  1 
ATOM   1659 C C   . LYS   B 1 80  ? 19.13346  -19.04157 -0.09495  1.000 28.43747 ? 77  LYS   B C   1 
ATOM   1660 O O   . LYS   B 1 80  ? 19.98800  -19.70653 -0.68876  1.000 28.71265 ? 77  LYS   B O   1 
ATOM   1661 C CB  . LYS   B 1 80  ? 17.24402  -20.68802 -0.15894  1.000 31.43957 ? 77  LYS   B CB  1 
ATOM   1662 C CG  . LYS   B 1 80  ? 17.51562  -21.19299 1.25467   1.000 39.04555 ? 77  LYS   B CG  1 
ATOM   1663 C CD  . LYS   B 1 80  ? 17.54285  -22.71871 1.28129   1.000 50.72012 ? 77  LYS   B CD  1 
ATOM   1664 C CE  . LYS   B 1 80  ? 17.80244  -23.26201 2.67747   1.000 57.10547 ? 77  LYS   B CE  1 
ATOM   1665 N NZ  . LYS   B 1 80  ? 16.61876  -23.10563 3.56820   1.000 58.50558 ? 77  LYS   B NZ  1 
ATOM   1666 N N   . ILE   B 1 81  ? 19.42904  -18.14079 0.84103   1.000 23.22623 ? 78  ILE   B N   1 
ATOM   1667 C CA  . ILE   B 1 81  ? 20.80294  -17.91097 1.28295   1.000 22.43816 ? 78  ILE   B CA  1 
ATOM   1668 C C   . ILE   B 1 81  ? 21.20462  -19.00032 2.26652   1.000 28.70757 ? 78  ILE   B C   1 
ATOM   1669 O O   . ILE   B 1 81  ? 20.54405  -19.19955 3.29358   1.000 27.40729 ? 78  ILE   B O   1 
ATOM   1670 C CB  . ILE   B 1 81  ? 20.94650  -16.52449 1.92641   1.000 22.96183 ? 78  ILE   B CB  1 
ATOM   1671 C CG1 . ILE   B 1 81  ? 20.53469  -15.43129 0.94358   1.000 30.40376 ? 78  ILE   B CG1 1 
ATOM   1672 C CG2 . ILE   B 1 81  ? 22.38006  -16.31105 2.40496   1.000 26.19629 ? 78  ILE   B CG2 1 
ATOM   1673 C CD1 . ILE   B 1 81  ? 21.59334  -15.07530 -0.06555  1.000 27.66331 ? 78  ILE   B CD1 1 
ATOM   1674 N N   . THR   B 1 82  ? 22.31052  -19.68894 1.97298   1.000 25.31930 ? 79  THR   B N   1 
ATOM   1675 C CA  . THR   B 1 82  ? 22.75201  -20.81448 2.78016   1.000 25.47567 ? 79  THR   B CA  1 
ATOM   1676 C C   . THR   B 1 82  ? 24.10594  -20.62580 3.45249   1.000 27.40700 ? 79  THR   B C   1 
ATOM   1677 O O   . THR   B 1 82  ? 24.46389  -21.44427 4.30721   1.000 28.22998 ? 79  THR   B O   1 
ATOM   1678 C CB  . THR   B 1 82  ? 22.81401  -22.08261 1.92071   1.000 32.24527 ? 79  THR   B CB  1 
ATOM   1679 O OG1 . THR   B 1 82  ? 23.70014  -21.85242 0.82189   1.000 33.38100 ? 79  THR   B OG1 1 
ATOM   1680 C CG2 . THR   B 1 82  ? 21.43572  -22.42879 1.39337   1.000 31.98034 ? 79  THR   B CG2 1 
ATOM   1681 N N   . ARG   B 1 83  ? 24.86752  -19.59191 3.10578   1.000 25.11294 ? 80  ARG   B N   1 
ATOM   1682 C CA  . ARG   B 1 83  ? 26.20250  -19.44189 3.66817   1.000 22.02270 ? 80  ARG   B CA  1 
ATOM   1683 C C   . ARG   B 1 83  ? 26.12966  -19.13104 5.15981   1.000 24.15696 ? 80  ARG   B C   1 
ATOM   1684 O O   . ARG   B 1 83  ? 25.13785  -18.59251 5.65749   1.000 26.48719 ? 80  ARG   B O   1 
ATOM   1685 C CB  . ARG   B 1 83  ? 26.97088  -18.33754 2.93263   1.000 24.74343 ? 80  ARG   B CB  1 
ATOM   1686 C CG  . ARG   B 1 83  ? 26.49707  -16.91361 3.24009   1.000 26.04916 ? 80  ARG   B CG  1 
ATOM   1687 C CD  . ARG   B 1 83  ? 27.35572  -15.85111 2.54028   1.000 25.80993 ? 80  ARG   B CD  1 
ATOM   1688 N NE  . ARG   B 1 83  ? 27.26503  -15.90833 1.08399   1.000 23.31215 ? 80  ARG   B NE  1 
ATOM   1689 C CZ  . ARG   B 1 83  ? 26.39191  -15.23564 0.34561   1.000 24.82558 ? 80  ARG   B CZ  1 
ATOM   1690 N NH1 . ARG   B 1 83  ? 25.47073  -14.45211 0.89548   1.000 21.23581 ? 80  ARG   B NH1 1 
ATOM   1691 N NH2 . ARG   B 1 83  ? 26.44089  -15.34872 -0.98078  1.000 20.56151 ? 80  ARG   B NH2 1 
ATOM   1692 N N   . THR   B 1 84  ? 27.18782  -19.49509 5.88103   1.000 24.75295 ? 81  THR   B N   1 
ATOM   1693 C CA  . THR   B 1 84  ? 27.23214  -19.23111 7.31152   1.000 28.62462 ? 81  THR   B CA  1 
ATOM   1694 C C   . THR   B 1 84  ? 27.65255  -17.78763 7.57671   1.000 23.71031 ? 81  THR   B C   1 
ATOM   1695 O O   . THR   B 1 84  ? 28.10218  -17.06561 6.68159   1.000 25.66739 ? 81  THR   B O   1 
ATOM   1696 C CB  . THR   B 1 84  ? 28.19537  -20.18719 8.02147   1.000 31.28045 ? 81  THR   B CB  1 
ATOM   1697 O OG1 . THR   B 1 84  ? 29.54433  -19.86007 7.66495   1.000 30.94835 ? 81  THR   B OG1 1 
ATOM   1698 C CG2 . THR   B 1 84  ? 27.89985  -21.63152 7.64432   1.000 33.17433 ? 81  THR   B CG2 1 
ATOM   1699 N N   . LYS   B 1 85  ? 27.49500  -17.36717 8.83520   1.000 24.30316 ? 82  LYS   B N   1 
ATOM   1700 C CA  . LYS   B 1 85  ? 27.94986  -16.03898 9.22880   1.000 24.21928 ? 82  LYS   B CA  1 
ATOM   1701 C C   . LYS   B 1 85  ? 29.46033  -15.89605 9.05540   1.000 28.88209 ? 82  LYS   B C   1 
ATOM   1702 O O   . LYS   B 1 85  ? 29.94364  -14.84274 8.62772   1.000 25.54156 ? 82  LYS   B O   1 
ATOM   1703 C CB  . LYS   B 1 85  ? 27.53504  -15.74856 10.67046  1.000 30.08394 ? 82  LYS   B CB  1 
ATOM   1704 C CG  . LYS   B 1 85  ? 27.90289  -14.36093 11.16450  1.000 34.89314 ? 82  LYS   B CG  1 
ATOM   1705 C CD  . LYS   B 1 85  ? 27.06046  -13.96816 12.37735  1.000 37.76693 ? 82  LYS   B CD  1 
ATOM   1706 C CE  . LYS   B 1 85  ? 27.11091  -15.01878 13.47489  1.000 44.41915 ? 82  LYS   B CE  1 
ATOM   1707 N NZ  . LYS   B 1 85  ? 28.31505  -14.87058 14.33562  1.000 57.17621 ? 82  LYS   B NZ  1 
ATOM   1708 N N   . GLU   B 1 86  ? 30.22607  -16.94528 9.36855   1.000 28.47265 ? 83  GLU   B N   1 
ATOM   1709 C CA  . GLU   B 1 86  ? 31.67118  -16.86213 9.16512   1.000 29.74078 ? 83  GLU   B CA  1 
ATOM   1710 C C   . GLU   B 1 86  ? 32.01687  -16.78663 7.68023   1.000 25.36424 ? 83  GLU   B C   1 
ATOM   1711 O O   . GLU   B 1 86  ? 32.94395  -16.06628 7.29268   1.000 31.66741 ? 83  GLU   B O   1 
ATOM   1712 C CB  . GLU   B 1 86  ? 32.37751  -18.05173 9.82228   1.000 35.53938 ? 83  GLU   B CB  1 
ATOM   1713 C CG  . GLU   B 1 86  ? 33.90660  -17.98838 9.73799   1.000 44.91510 ? 83  GLU   B CG  1 
ATOM   1714 C CD  . GLU   B 1 86  ? 34.50021  -16.81028 10.50604  1.000 52.00917 ? 83  GLU   B CD  1 
ATOM   1715 O OE1 . GLU   B 1 86  ? 34.24537  -16.69245 11.72486  1.000 53.00959 ? 83  GLU   B OE1 1 
ATOM   1716 O OE2 . GLU   B 1 86  ? 35.22145  -15.99817 9.88696   1.000 50.91517 ? 83  GLU   B OE2 1 
ATOM   1717 N N   . GLU   B 1 87  ? 31.28701  -17.52516 6.83827   1.000 27.78144 ? 84  GLU   B N   1 
ATOM   1718 C CA  . GLU   B 1 87  ? 31.48182  -17.42657 5.39392   1.000 26.46091 ? 84  GLU   B CA  1 
ATOM   1719 C C   . GLU   B 1 87  ? 31.18192  -16.02052 4.89434   1.000 25.23573 ? 84  GLU   B C   1 
ATOM   1720 O O   . GLU   B 1 87  ? 31.90229  -15.48602 4.04455   1.000 26.27176 ? 84  GLU   B O   1 
ATOM   1721 C CB  . GLU   B 1 87  ? 30.58490  -18.42383 4.66028   1.000 28.28568 ? 84  GLU   B CB  1 
ATOM   1722 C CG  . GLU   B 1 87  ? 30.97676  -19.88674 4.76408   1.000 33.51625 ? 84  GLU   B CG  1 
ATOM   1723 C CD  . GLU   B 1 87  ? 29.99699  -20.77905 4.01971   1.000 34.80283 ? 84  GLU   B CD  1 
ATOM   1724 O OE1 . GLU   B 1 87  ? 30.16264  -20.97580 2.79769   1.000 43.96685 ? 84  GLU   B OE1 1 
ATOM   1725 O OE2 . GLU   B 1 87  ? 29.04410  -21.26879 4.65317   1.000 39.16654 ? 84  GLU   B OE2 1 
ATOM   1726 N N   . ALA   B 1 88  ? 30.09568  -15.42104 5.38462   1.000 22.45925 ? 85  ALA   B N   1 
ATOM   1727 C CA  . ALA   B 1 88  ? 29.75323  -14.06749 4.96206   1.000 21.17446 ? 85  ALA   B CA  1 
ATOM   1728 C C   . ALA   B 1 88  ? 30.81945  -13.07345 5.39852   1.000 21.67823 ? 85  ALA   B C   1 
ATOM   1729 O O   . ALA   B 1 88  ? 31.13507  -12.12532 4.66765   1.000 21.67750 ? 85  ALA   B O   1 
ATOM   1730 C CB  . ALA   B 1 88  ? 28.38298  -13.67831 5.52602   1.000 21.42516 ? 85  ALA   B CB  1 
ATOM   1731 N N   . LEU   B 1 89  ? 31.39551  -13.27807 6.58609   1.000 22.65333 ? 86  LEU   B N   1 
ATOM   1732 C CA  . LEU   B 1 89  ? 32.44000  -12.37841 7.06345   1.000 18.32778 ? 86  LEU   B CA  1 
ATOM   1733 C C   . LEU   B 1 89  ? 33.69712  -12.49675 6.20878   1.000 22.30098 ? 86  LEU   B C   1 
ATOM   1734 O O   . LEU   B 1 89  ? 34.36004  -11.49186 5.93524   1.000 21.88279 ? 86  LEU   B O   1 
ATOM   1735 C CB  . LEU   B 1 89  ? 32.75407  -12.66511 8.53314   1.000 23.08711 ? 86  LEU   B CB  1 
ATOM   1736 C CG  . LEU   B 1 89  ? 33.84355  -11.79742 9.17730   1.000 20.12406 ? 86  LEU   B CG  1 
ATOM   1737 C CD1 . LEU   B 1 89  ? 33.49807  -10.31206 9.14457   1.000 21.98829 ? 86  LEU   B CD1 1 
ATOM   1738 C CD2 . LEU   B 1 89  ? 34.10822  -12.24010 10.60816  1.000 25.41672 ? 86  LEU   B CD2 1 
ATOM   1739 N N   . GLU   B 1 90  ? 34.03070  -13.71628 5.77171   1.000 23.57886 ? 87  GLU   B N   1 
ATOM   1740 C CA  . GLU   B 1 90  ? 35.17804  -13.90718 4.88346   1.000 24.73396 ? 87  GLU   B CA  1 
ATOM   1741 C C   . GLU   B 1 90  ? 34.99663  -13.14389 3.57726   1.000 25.30778 ? 87  GLU   B C   1 
ATOM   1742 O O   . GLU   B 1 90  ? 35.94054  -12.52293 3.07201   1.000 26.16698 ? 87  GLU   B O   1 
ATOM   1743 C CB  . GLU   B 1 90  ? 35.37849  -15.39905 4.60100   1.000 28.25821 ? 87  GLU   B CB  1 
ATOM   1744 C CG  . GLU   B 1 90  ? 36.00439  -16.18196 5.74823   1.000 45.75781 ? 87  GLU   B CG  1 
ATOM   1745 C CD  . GLU   B 1 90  ? 35.76866  -17.68225 5.64268   1.000 53.24537 ? 87  GLU   B CD  1 
ATOM   1746 O OE1 . GLU   B 1 90  ? 35.27752  -18.14652 4.58996   1.000 49.87716 ? 87  GLU   B OE1 1 
ATOM   1747 O OE2 . GLU   B 1 90  ? 36.06923  -18.39700 6.62305   1.000 58.93560 ? 87  GLU   B OE2 1 
ATOM   1748 N N   . LEU   B 1 91  ? 33.78530  -13.18391 3.01531   1.000 24.09253 ? 88  LEU   B N   1 
ATOM   1749 C CA  . LEU   B 1 91  ? 33.50283  -12.45494 1.78430   1.000 23.10195 ? 88  LEU   B CA  1 
ATOM   1750 C C   . LEU   B 1 91  ? 33.61079  -10.95317 2.00053   1.000 20.11900 ? 88  LEU   B C   1 
ATOM   1751 O O   . LEU   B 1 91  ? 34.20016  -10.23428 1.18404   1.000 20.44788 ? 88  LEU   B O   1 
ATOM   1752 C CB  . LEU   B 1 91  ? 32.10732  -12.82198 1.27999   1.000 21.48629 ? 88  LEU   B CB  1 
ATOM   1753 C CG  . LEU   B 1 91  ? 31.98512  -14.22549 0.69626   1.000 17.81475 ? 88  LEU   B CG  1 
ATOM   1754 C CD1 . LEU   B 1 91  ? 30.56980  -14.75393 0.84033   1.000 22.69118 ? 88  LEU   B CD1 1 
ATOM   1755 C CD2 . LEU   B 1 91  ? 32.38348  -14.16343 -0.75705  1.000 21.03378 ? 88  LEU   B CD2 1 
ATOM   1756 N N   . ILE   B 1 92  ? 33.02980  -10.46138 3.09983   1.000 18.66778 ? 89  ILE   B N   1 
ATOM   1757 C CA  . ILE   B 1 92  ? 33.08813  -9.04105  3.42722   1.000 19.47997 ? 89  ILE   B CA  1 
ATOM   1758 C C   . ILE   B 1 92  ? 34.53136  -8.58856  3.57652   1.000 23.84074 ? 89  ILE   B C   1 
ATOM   1759 O O   . ILE   B 1 92  ? 34.92561  -7.53551  3.06107   1.000 21.10024 ? 89  ILE   B O   1 
ATOM   1760 C CB  . ILE   B 1 92  ? 32.27364  -8.77426  4.70877   1.000 18.69460 ? 89  ILE   B CB  1 
ATOM   1761 C CG1 . ILE   B 1 92  ? 30.77107  -8.83224  4.40457   1.000 19.13667 ? 89  ILE   B CG1 1 
ATOM   1762 C CG2 . ILE   B 1 92  ? 32.65866  -7.44605  5.32888   1.000 19.56450 ? 89  ILE   B CG2 1 
ATOM   1763 C CD1 . ILE   B 1 92  ? 30.23711  -7.58790  3.70923   1.000 17.62211 ? 89  ILE   B CD1 1 
ATOM   1764 N N   . ASN   B 1 93  ? 35.34367  -9.38250  4.27587   1.000 22.12618 ? 90  ASN   B N   1 
ATOM   1765 C CA  . ASN   B 1 93  ? 36.73678  -9.00470  4.47401   1.000 22.63410 ? 90  ASN   B CA  1 
ATOM   1766 C C   . ASN   B 1 93  ? 37.48346  -8.95542  3.14617   1.000 21.68302 ? 90  ASN   B C   1 
ATOM   1767 O O   . ASN   B 1 93  ? 38.32703  -8.07406  2.93583   1.000 22.79520 ? 90  ASN   B O   1 
ATOM   1768 C CB  . ASN   B 1 93  ? 37.40060  -9.97442  5.45067   1.000 24.66291 ? 90  ASN   B CB  1 
ATOM   1769 C CG  . ASN   B 1 93  ? 37.05699  -9.66443  6.89670   1.000 23.24102 ? 90  ASN   B CG  1 
ATOM   1770 O OD1 . ASN   B 1 93  ? 36.82027  -8.51297  7.25396   1.000 31.02117 ? 90  ASN   B OD1 1 
ATOM   1771 N ND2 . ASN   B 1 93  ? 37.04166  -10.68617 7.73312   1.000 30.97319 ? 90  ASN   B ND2 1 
ATOM   1772 N N   . GLY   B 1 94  ? 37.15902  -9.86908  2.22704   1.000 21.41800 ? 91  GLY   B N   1 
ATOM   1773 C CA  . GLY   B 1 94  ? 37.76216  -9.82090  0.90247   1.000 25.60167 ? 91  GLY   B CA  1 
ATOM   1774 C C   . GLY   B 1 94  ? 37.40503  -8.56159  0.13619   1.000 28.16678 ? 91  GLY   B C   1 
ATOM   1775 O O   . GLY   B 1 94  ? 38.26717  -7.92956  -0.47877  1.000 26.25687 ? 91  GLY   B O   1 
ATOM   1776 N N   . TYR   B 1 95  ? 36.12691  -8.17527  0.16166   1.000 21.21789 ? 92  TYR   B N   1 
ATOM   1777 C CA  . TYR   B 1 95  ? 35.71360  -6.96216  -0.53787  1.000 20.12701 ? 92  TYR   B CA  1 
ATOM   1778 C C   . TYR   B 1 95  ? 36.39805  -5.72737  0.03105   1.000 21.41456 ? 92  TYR   B C   1 
ATOM   1779 O O   . TYR   B 1 95  ? 36.81029  -4.84210  -0.72318  1.000 23.95047 ? 92  TYR   B O   1 
ATOM   1780 C CB  . TYR   B 1 95  ? 34.19427  -6.79095  -0.46394  1.000 16.53537 ? 92  TYR   B CB  1 
ATOM   1781 C CG  . TYR   B 1 95  ? 33.39995  -7.91831  -1.08057  1.000 17.48932 ? 92  TYR   B CG  1 
ATOM   1782 C CD1 . TYR   B 1 95  ? 33.84571  -8.58213  -2.21627  1.000 18.73629 ? 92  TYR   B CD1 1 
ATOM   1783 C CD2 . TYR   B 1 95  ? 32.19123  -8.32244  -0.52379  1.000 15.90366 ? 92  TYR   B CD2 1 
ATOM   1784 C CE1 . TYR   B 1 95  ? 33.11584  -9.62139  -2.78042  1.000 20.59294 ? 92  TYR   B CE1 1 
ATOM   1785 C CE2 . TYR   B 1 95  ? 31.45724  -9.35021  -1.07746  1.000 17.23362 ? 92  TYR   B CE2 1 
ATOM   1786 C CZ  . TYR   B 1 95  ? 31.92267  -10.00830 -2.19926  1.000 19.95682 ? 92  TYR   B CZ  1 
ATOM   1787 O OH  . TYR   B 1 95  ? 31.18966  -11.03393 -2.73976  1.000 19.81155 ? 92  TYR   B OH  1 
ATOM   1788 N N   . ILE   B 1 96  ? 36.50631  -5.63490  1.36051   1.000 22.07478 ? 93  ILE   B N   1 
ATOM   1789 C CA  . ILE   B 1 96  ? 37.17076  -4.48582  1.97252   1.000 19.08795 ? 93  ILE   B CA  1 
ATOM   1790 C C   . ILE   B 1 96  ? 38.61293  -4.37947  1.48735   1.000 21.07100 ? 93  ILE   B C   1 
ATOM   1791 O O   . ILE   B 1 96  ? 39.08968  -3.29019  1.15296   1.000 24.04201 ? 93  ILE   B O   1 
ATOM   1792 C CB  . ILE   B 1 96  ? 37.10272  -4.57628  3.50783   1.000 22.54916 ? 93  ILE   B CB  1 
ATOM   1793 C CG1 . ILE   B 1 96  ? 35.65827  -4.41279  3.99085   1.000 18.25697 ? 93  ILE   B CG1 1 
ATOM   1794 C CG2 . ILE   B 1 96  ? 37.98489  -3.50982  4.13908   1.000 24.86899 ? 93  ILE   B CG2 1 
ATOM   1795 C CD1 . ILE   B 1 96  ? 35.49554  -4.64279  5.48117   1.000 23.21108 ? 93  ILE   B CD1 1 
ATOM   1796 N N   . GLN   B 1 97  ? 39.32566  -5.50644  1.44319   1.000 24.45834 ? 94  GLN   B N   1 
ATOM   1797 C CA  . GLN   B 1 97  ? 40.72112  -5.48077  1.01365   1.000 27.52315 ? 94  GLN   B CA  1 
ATOM   1798 C C   . GLN   B 1 97  ? 40.83978  -5.05102  -0.44376  1.000 32.41588 ? 94  GLN   B C   1 
ATOM   1799 O O   . GLN   B 1 97  ? 41.72695  -4.26333  -0.79748  1.000 33.68641 ? 94  GLN   B O   1 
ATOM   1800 C CB  . GLN   B 1 97  ? 41.35234  -6.85587  1.23725   1.000 29.10227 ? 94  GLN   B CB  1 
ATOM   1801 C CG  . GLN   B 1 97  ? 42.87540  -6.86385  1.24248   1.000 45.95128 ? 94  GLN   B CG  1 
ATOM   1802 C CD  . GLN   B 1 97  ? 43.46875  -7.38219  -0.05549  1.000 55.33768 ? 94  GLN   B CD  1 
ATOM   1803 O OE1 . GLN   B 1 97  ? 42.98001  -7.07763  -1.14241  1.000 51.09799 ? 94  GLN   B OE1 1 
ATOM   1804 N NE2 . GLN   B 1 97  ? 44.52743  -8.17729  0.05534   1.000 54.79151 ? 94  GLN   B NE2 1 
ATOM   1805 N N   . LYS   B 1 98  ? 39.94934  -5.55246  -1.30393  1.000 29.33178 ? 95  LYS   B N   1 
ATOM   1806 C CA  . LYS   B 1 98  ? 39.95306  -5.14024  -2.70311  1.000 27.75086 ? 95  LYS   B CA  1 
ATOM   1807 C C   . LYS   B 1 98  ? 39.62654  -3.66025  -2.85720  1.000 32.04772 ? 95  LYS   B C   1 
ATOM   1808 O O   . LYS   B 1 98  ? 40.14142  -3.00427  -3.77137  1.000 33.72216 ? 95  LYS   B O   1 
ATOM   1809 C CB  . LYS   B 1 98  ? 38.96257  -5.98816  -3.49998  1.000 33.30865 ? 95  LYS   B CB  1 
ATOM   1810 C CG  . LYS   B 1 98  ? 39.30229  -7.46952  -3.54042  1.000 35.12166 ? 95  LYS   B CG  1 
ATOM   1811 C CD  . LYS   B 1 98  ? 39.83925  -7.87279  -4.90374  1.000 48.75355 ? 95  LYS   B CD  1 
ATOM   1812 C CE  . LYS   B 1 98  ? 40.34305  -9.30844  -4.90719  1.000 55.06476 ? 95  LYS   B CE  1 
ATOM   1813 N NZ  . LYS   B 1 98  ? 40.90187  -9.69078  -6.23545  1.000 56.73566 ? 95  LYS   B NZ  1 
ATOM   1814 N N   . ILE   B 1 99  ? 38.78049  -3.11172  -1.98461  1.000 23.97536 ? 96  ILE   B N   1 
ATOM   1815 C CA  . ILE   B 1 99  ? 38.42688  -1.70006  -2.09956  1.000 25.28205 ? 96  ILE   B CA  1 
ATOM   1816 C C   . ILE   B 1 99  ? 39.59117  -0.82433  -1.65681  1.000 31.92318 ? 96  ILE   B C   1 
ATOM   1817 O O   . ILE   B 1 99  ? 39.94700  0.15341   -2.32677  1.000 31.93185 ? 96  ILE   B O   1 
ATOM   1818 C CB  . ILE   B 1 99  ? 37.14984  -1.39688  -1.29153  1.000 23.09686 ? 96  ILE   B CB  1 
ATOM   1819 C CG1 . ILE   B 1 99  ? 35.93316  -2.02283  -1.97095  1.000 20.37060 ? 96  ILE   B CG1 1 
ATOM   1820 C CG2 . ILE   B 1 99  ? 36.93304  0.09660   -1.17400  1.000 24.46327 ? 96  ILE   B CG2 1 
ATOM   1821 C CD1 . ILE   B 1 99  ? 34.72222  -2.07173  -1.05812  1.000 23.36228 ? 96  ILE   B CD1 1 
ATOM   1822 N N   . LYS   B 1 100 ? 40.21087  -1.17207  -0.52808  1.000 32.03605 ? 97  LYS   B N   1 
ATOM   1823 C CA  . LYS   B 1 100 ? 41.30074  -0.35816  0.00207   1.000 32.10191 ? 97  LYS   B CA  1 
ATOM   1824 C C   . LYS   B 1 100 ? 42.50508  -0.36296  -0.92733  1.000 33.50378 ? 97  LYS   B C   1 
ATOM   1825 O O   . LYS   B 1 100 ? 43.19041  0.65552   -1.06707  1.000 39.92930 ? 97  LYS   B O   1 
ATOM   1826 C CB  . LYS   B 1 100 ? 41.70296  -0.86536  1.38034   1.000 32.67197 ? 97  LYS   B CB  1 
ATOM   1827 C CG  . LYS   B 1 100 ? 40.69592  -0.58775  2.45999   1.000 31.00558 ? 97  LYS   B CG  1 
ATOM   1828 C CD  . LYS   B 1 100 ? 41.21719  -1.10814  3.76418   1.000 36.64627 ? 97  LYS   B CD  1 
ATOM   1829 C CE  . LYS   B 1 100 ? 40.93298  -0.12842  4.86791   1.000 37.58471 ? 97  LYS   B CE  1 
ATOM   1830 N NZ  . LYS   B 1 100 ? 41.43816  -0.58433  6.18497   1.000 29.53819 ? 97  LYS   B NZ  1 
ATOM   1831 N N   . SER   B 1 101 ? 42.77399  -1.49673  -1.57084  1.000 33.12304 ? 98  SER   B N   1 
ATOM   1832 C CA  . SER   B 1 101 ? 43.92987  -1.62856  -2.44627  1.000 41.37424 ? 98  SER   B CA  1 
ATOM   1833 C C   . SER   B 1 101 ? 43.74706  -0.93686  -3.78812  1.000 39.76879 ? 98  SER   B C   1 
ATOM   1834 O O   . SER   B 1 101 ? 44.73187  -0.77538  -4.51684  1.000 40.28262 ? 98  SER   B O   1 
ATOM   1835 C CB  . SER   B 1 101 ? 44.23715  -3.10513  -2.68851  1.000 34.19491 ? 98  SER   B CB  1 
ATOM   1836 O OG  . SER   B 1 101 ? 43.26698  -3.68479  -3.54646  1.000 37.21228 ? 98  SER   B OG  1 
ATOM   1837 N N   . GLY   B 1 102 ? 42.52886  -0.53298  -4.13514  1.000 36.08670 ? 99  GLY   B N   1 
ATOM   1838 C CA  . GLY   B 1 102 ? 42.25891  0.02800   -5.43968  1.000 31.79275 ? 99  GLY   B CA  1 
ATOM   1839 C C   . GLY   B 1 102 ? 41.98454  -0.97977  -6.53419  1.000 35.91894 ? 99  GLY   B C   1 
ATOM   1840 O O   . GLY   B 1 102 ? 41.75029  -0.56957  -7.67567  1.000 34.72613 ? 99  GLY   B O   1 
ATOM   1841 N N   . GLU   B 1 103 ? 42.01482  -2.28244  -6.23234  1.000 33.51560 ? 100 GLU   B N   1 
ATOM   1842 C CA  . GLU   B 1 103 ? 41.69610  -3.28331  -7.24701  1.000 39.47611 ? 100 GLU   B CA  1 
ATOM   1843 C C   . GLU   B 1 103 ? 40.27989  -3.10420  -7.77279  1.000 38.49284 ? 100 GLU   B C   1 
ATOM   1844 O O   . GLU   B 1 103 ? 40.04543  -3.16366  -8.98538  1.000 37.79582 ? 100 GLU   B O   1 
ATOM   1845 C CB  . GLU   B 1 103 ? 41.85964  -4.69306  -6.67996  1.000 39.19024 ? 100 GLU   B CB  1 
ATOM   1846 C CG  . GLU   B 1 103 ? 43.28303  -5.11508  -6.39218  1.000 47.55114 ? 100 GLU   B CG  1 
ATOM   1847 C CD  . GLU   B 1 103 ? 43.33535  -6.38757  -5.57218  1.000 51.05447 ? 100 GLU   B CD  1 
ATOM   1848 O OE1 . GLU   B 1 103 ? 42.99172  -7.46297  -6.11015  1.000 56.43186 ? 100 GLU   B OE1 1 
ATOM   1849 O OE2 . GLU   B 1 103 ? 43.69788  -6.30594  -4.37903  1.000 54.54781 ? 100 GLU   B OE2 1 
ATOM   1850 N N   . GLU   B 1 104 ? 39.31952  -2.89920  -6.87591  1.000 34.09516 ? 101 GLU   B N   1 
ATOM   1851 C CA  . GLU   B 1 104 ? 37.92146  -2.77755  -7.24993  1.000 30.30188 ? 101 GLU   B CA  1 
ATOM   1852 C C   . GLU   B 1 104 ? 37.31964  -1.55900  -6.56540  1.000 26.55684 ? 101 GLU   B C   1 
ATOM   1853 O O   . GLU   B 1 104 ? 37.82643  -1.07675  -5.54763  1.000 29.38920 ? 101 GLU   B O   1 
ATOM   1854 C CB  . GLU   B 1 104 ? 37.13377  -4.04550  -6.88811  1.000 33.85555 ? 101 GLU   B CB  1 
ATOM   1855 C CG  . GLU   B 1 104 ? 37.08253  -5.09247  -8.00277  1.000 42.71066 ? 101 GLU   B CG  1 
ATOM   1856 C CD  . GLU   B 1 104 ? 35.87568  -4.91533  -8.90963  1.000 45.42880 ? 101 GLU   B CD  1 
ATOM   1857 O OE1 . GLU   B 1 104 ? 35.45859  -3.75247  -9.12465  1.000 41.35172 ? 101 GLU   B OE1 1 
ATOM   1858 O OE2 . GLU   B 1 104 ? 35.33061  -5.93755  -9.39261  1.000 43.28655 ? 101 GLU   B OE2 1 
ATOM   1859 N N   . ASP   B 1 105 ? 36.23686  -1.05865  -7.14755  1.000 26.94136 ? 102 ASP   B N   1 
ATOM   1860 C CA  . ASP   B 1 105 ? 35.53506  0.10254   -6.63084  1.000 28.66169 ? 102 ASP   B CA  1 
ATOM   1861 C C   . ASP   B 1 105 ? 34.36120  -0.34987  -5.77083  1.000 23.50864 ? 102 ASP   B C   1 
ATOM   1862 O O   . ASP   B 1 105 ? 33.79026  -1.42156  -5.98691  1.000 24.99615 ? 102 ASP   B O   1 
ATOM   1863 C CB  . ASP   B 1 105 ? 35.03536  0.99805   -7.76723  1.000 34.53478 ? 102 ASP   B CB  1 
ATOM   1864 C CG  . ASP   B 1 105 ? 36.16866  1.62978   -8.55396  1.000 45.98021 ? 102 ASP   B CG  1 
ATOM   1865 O OD1 . ASP   B 1 105 ? 37.27816  1.76498   -7.99735  1.000 39.77327 ? 102 ASP   B OD1 1 
ATOM   1866 O OD2 . ASP   B 1 105 ? 35.94963  1.99590   -9.72996  1.000 55.90576 ? 102 ASP   B OD2 1 
ATOM   1867 N N   . PHE   B 1 106 ? 34.00608  0.48269   -4.78830  1.000 21.95734 ? 103 PHE   B N   1 
ATOM   1868 C CA  . PHE   B 1 106 ? 32.89464  0.13868   -3.90320  1.000 26.19872 ? 103 PHE   B CA  1 
ATOM   1869 C C   . PHE   B 1 106 ? 31.60092  -0.04971  -4.68596  1.000 20.73196 ? 103 PHE   B C   1 
ATOM   1870 O O   . PHE   B 1 106 ? 30.89031  -1.04631  -4.50010  1.000 19.44127 ? 103 PHE   B O   1 
ATOM   1871 C CB  . PHE   B 1 106 ? 32.71593  1.21368   -2.82789  1.000 25.45520 ? 103 PHE   B CB  1 
ATOM   1872 C CG  . PHE   B 1 106 ? 31.49396  1.00868   -1.97707  1.000 20.84976 ? 103 PHE   B CG  1 
ATOM   1873 C CD1 . PHE   B 1 106 ? 30.27033  1.53562   -2.35953  1.000 22.32453 ? 103 PHE   B CD1 1 
ATOM   1874 C CD2 . PHE   B 1 106 ? 31.56408  0.27057   -0.81068  1.000 23.59448 ? 103 PHE   B CD2 1 
ATOM   1875 C CE1 . PHE   B 1 106 ? 29.14031  1.33877   -1.58964  1.000 22.30643 ? 103 PHE   B CE1 1 
ATOM   1876 C CE2 . PHE   B 1 106 ? 30.42784  0.07212   -0.03562  1.000 22.51795 ? 103 PHE   B CE2 1 
ATOM   1877 C CZ  . PHE   B 1 106 ? 29.22516  0.60410   -0.43359  1.000 24.86973 ? 103 PHE   B CZ  1 
ATOM   1878 N N   . GLU   B 1 107 ? 31.26103  0.91466   -5.55155  1.000 21.56786 ? 104 GLU   B N   1 
ATOM   1879 C CA  . GLU   B 1 107 ? 29.99493  0.84890   -6.27693  1.000 21.12965 ? 104 GLU   B CA  1 
ATOM   1880 C C   . GLU   B 1 107 ? 29.91836  -0.40172  -7.14614  1.000 21.68601 ? 104 GLU   B C   1 
ATOM   1881 O O   . GLU   B 1 107 ? 28.85238  -1.00970  -7.28389  1.000 21.51311 ? 104 GLU   B O   1 
ATOM   1882 C CB  . GLU   B 1 107 ? 29.80680  2.10199   -7.14150  1.000 19.73999 ? 104 GLU   B CB  1 
ATOM   1883 C CG  . GLU   B 1 107 ? 29.63470  3.40317   -6.36684  1.000 27.30638 ? 104 GLU   B CG  1 
ATOM   1884 C CD  . GLU   B 1 107 ? 29.20923  4.56418   -7.25798  1.000 34.09488 ? 104 GLU   B CD  1 
ATOM   1885 O OE1 . GLU   B 1 107 ? 29.10551  4.37462   -8.48804  1.000 35.61769 ? 104 GLU   B OE1 1 
ATOM   1886 O OE2 . GLU   B 1 107 ? 28.96895  5.66814   -6.72766  1.000 37.77514 ? 104 GLU   B OE2 1 
ATOM   1887 N N   . SER   B 1 108 ? 31.04049  -0.79134  -7.74979  1.000 23.02857 ? 105 SER   B N   1 
ATOM   1888 C CA  . SER   B 1 108 ? 31.06472  -1.98016  -8.59597  1.000 20.71183 ? 105 SER   B CA  1 
ATOM   1889 C C   . SER   B 1 108 ? 30.81200  -3.24775  -7.78750  1.000 17.90053 ? 105 SER   B C   1 
ATOM   1890 O O   . SER   B 1 108 ? 30.00779  -4.10097  -8.18400  1.000 20.36495 ? 105 SER   B O   1 
ATOM   1891 C CB  . SER   B 1 108 ? 32.40830  -2.06719  -9.31213  1.000 21.54964 ? 105 SER   B CB  1 
ATOM   1892 O OG  . SER   B 1 108 ? 32.48980  -3.27050  -10.05090 1.000 21.64367 ? 105 SER   B OG  1 
ATOM   1893 N N   . LEU   B 1 109 ? 31.51352  -3.39972  -6.66495  1.000 21.29415 ? 106 LEU   B N   1 
ATOM   1894 C CA  . LEU   B 1 109 ? 31.29732  -4.56884  -5.81793  1.000 17.44659 ? 106 LEU   B CA  1 
ATOM   1895 C C   . LEU   B 1 109 ? 29.88090  -4.59189  -5.25431  1.000 19.14907 ? 106 LEU   B C   1 
ATOM   1896 O O   . LEU   B 1 109 ? 29.26477  -5.65868  -5.16495  1.000 19.33325 ? 106 LEU   B O   1 
ATOM   1897 C CB  . LEU   B 1 109 ? 32.32599  -4.60368  -4.69765  1.000 18.51619 ? 106 LEU   B CB  1 
ATOM   1898 C CG  . LEU   B 1 109 ? 33.74637  -4.89731  -5.18800  1.000 20.98272 ? 106 LEU   B CG  1 
ATOM   1899 C CD1 . LEU   B 1 109 ? 34.73157  -4.91178  -4.03537  1.000 21.55785 ? 106 LEU   B CD1 1 
ATOM   1900 C CD2 . LEU   B 1 109 ? 33.75806  -6.21996  -5.93029  1.000 21.86685 ? 106 LEU   B CD2 1 
ATOM   1901 N N   . ALA   B 1 110 ? 29.34213  -3.42933  -4.86794  1.000 17.62574 ? 107 ALA   B N   1 
ATOM   1902 C CA  . ALA   B 1 110 ? 27.95757  -3.40682  -4.39352  1.000 17.54199 ? 107 ALA   B CA  1 
ATOM   1903 C C   . ALA   B 1 110 ? 26.98862  -3.84597  -5.48845  1.000 18.28879 ? 107 ALA   B C   1 
ATOM   1904 O O   . ALA   B 1 110 ? 26.06528  -4.62721  -5.22883  1.000 19.30001 ? 107 ALA   B O   1 
ATOM   1905 C CB  . ALA   B 1 110 ? 27.59113  -2.01364  -3.87245  1.000 17.14517 ? 107 ALA   B CB  1 
ATOM   1906 N N   . SER   B 1 111 ? 27.19455  -3.37082  -6.72662  1.000 18.35549 ? 108 SER   B N   1 
ATOM   1907 C CA  . SER   B 1 111 ? 26.30851  -3.74440  -7.82725  1.000 20.11052 ? 108 SER   B CA  1 
ATOM   1908 C C   . SER   B 1 111 ? 26.35953  -5.23825  -8.09860  1.000 19.55198 ? 108 SER   B C   1 
ATOM   1909 O O   . SER   B 1 111 ? 25.35333  -5.83793  -8.49412  1.000 24.46647 ? 108 SER   B O   1 
ATOM   1910 C CB  . SER   B 1 111 ? 26.69563  -2.98074  -9.10211  1.000 20.97058 ? 108 SER   B CB  1 
ATOM   1911 O OG  . SER   B 1 111 ? 26.56693  -1.57891  -8.93472  1.000 35.00039 ? 108 SER   B OG  1 
ATOM   1912 N N   . GLN   B 1 112 ? 27.52208  -5.85075  -7.89171  1.000 20.89876 ? 109 GLN   B N   1 
ATOM   1913 C CA  . GLN   B 1 112 ? 27.69287  -7.25091  -8.24478  1.000 17.97812 ? 109 GLN   B CA  1 
ATOM   1914 C C   . GLN   B 1 112 ? 27.21030  -8.18570  -7.14711  1.000 17.76681 ? 109 GLN   B C   1 
ATOM   1915 O O   . GLN   B 1 112 ? 26.67345  -9.25551  -7.44601  1.000 20.34239 ? 109 GLN   B O   1 
ATOM   1916 C CB  . GLN   B 1 112 ? 29.15942  -7.53791  -8.53678  1.000 19.33875 ? 109 GLN   B CB  1 
ATOM   1917 C CG  . GLN   B 1 112 ? 29.66354  -6.94405  -9.83549  1.000 19.92486 ? 109 GLN   B CG  1 
ATOM   1918 C CD  . GLN   B 1 112 ? 31.13772  -7.17987  -9.99386  1.000 18.63379 ? 109 GLN   B CD  1 
ATOM   1919 O OE1 . GLN   B 1 112 ? 31.95354  -6.25753  -9.84345  1.000 23.89398 ? 109 GLN   B OE1 1 
ATOM   1920 N NE2 . GLN   B 1 112 ? 31.50207  -8.42551  -10.26315 1.000 16.24924 ? 109 GLN   B NE2 1 
ATOM   1921 N N   . PHE   B 1 113 ? 27.41116  -7.81774  -5.87593  1.000 19.24393 ? 110 PHE   B N   1 
ATOM   1922 C CA  . PHE   B 1 113 ? 27.37887  -8.80769  -4.80482  1.000 17.87750 ? 110 PHE   B CA  1 
ATOM   1923 C C   . PHE   B 1 113 ? 26.50980  -8.45476  -3.61015  1.000 21.84114 ? 110 PHE   B C   1 
ATOM   1924 O O   . PHE   B 1 113 ? 26.25729  -9.33901  -2.78309  1.000 23.17030 ? 110 PHE   B O   1 
ATOM   1925 C CB  . PHE   B 1 113 ? 28.80622  -9.09079  -4.30594  1.000 18.58345 ? 110 PHE   B CB  1 
ATOM   1926 C CG  . PHE   B 1 113 ? 29.73243  -9.58112  -5.38458  1.000 21.99843 ? 110 PHE   B CG  1 
ATOM   1927 C CD1 . PHE   B 1 113 ? 29.43310  -10.73132 -6.09343  1.000 21.51104 ? 110 PHE   B CD1 1 
ATOM   1928 C CD2 . PHE   B 1 113 ? 30.89862  -8.89407  -5.68767  1.000 20.26641 ? 110 PHE   B CD2 1 
ATOM   1929 C CE1 . PHE   B 1 113 ? 30.28523  -11.19438 -7.09037  1.000 21.90089 ? 110 PHE   B CE1 1 
ATOM   1930 C CE2 . PHE   B 1 113 ? 31.75106  -9.34795  -6.69048  1.000 21.04960 ? 110 PHE   B CE2 1 
ATOM   1931 C CZ  . PHE   B 1 113 ? 31.43537  -10.50092 -7.38666  1.000 21.39268 ? 110 PHE   B CZ  1 
ATOM   1932 N N   . SER   B 1 114 ? 26.05694  -7.21384  -3.47359  1.000 20.40793 ? 111 SER   B N   1 
ATOM   1933 C CA  . SER   B 1 114 ? 25.19619  -6.88615  -2.34316  1.000 17.76362 ? 111 SER   B CA  1 
ATOM   1934 C C   . SER   B 1 114 ? 23.88054  -7.64574  -2.44181  1.000 19.13308 ? 111 SER   B C   1 
ATOM   1935 O O   . SER   B 1 114 ? 23.19806  -7.59740  -3.46908  1.000 22.37322 ? 111 SER   B O   1 
ATOM   1936 C CB  . SER   B 1 114 ? 24.92325  -5.38697  -2.28435  1.000 17.70419 ? 111 SER   B CB  1 
ATOM   1937 O OG  . SER   B 1 114 ? 24.14863  -5.10770  -1.12126  1.000 16.19168 ? 111 SER   B OG  1 
ATOM   1938 N N   . ASP   B 1 115 ? 23.51552  -8.33161  -1.35951  1.000 18.62186 ? 112 ASP   B N   1 
ATOM   1939 C CA  . ASP   B 1 115 ? 22.29193  -9.12608  -1.31137  1.000 18.57321 ? 112 ASP   B CA  1 
ATOM   1940 C C   . ASP   B 1 115 ? 21.07292  -8.23889  -1.07228  1.000 24.32782 ? 112 ASP   B C   1 
ATOM   1941 O O   . ASP   B 1 115 ? 20.27921  -8.48531  -0.15991  1.000 30.00955 ? 112 ASP   B O   1 
ATOM   1942 C CB  . ASP   B 1 115 ? 22.42156  -10.18344 -0.21566  1.000 14.63373 ? 112 ASP   B CB  1 
ATOM   1943 C CG  . ASP   B 1 115 ? 23.19367  -11.41456 -0.67505  1.000 18.42901 ? 112 ASP   B CG  1 
ATOM   1944 O OD1 . ASP   B 1 115 ? 22.87516  -11.93622 -1.76742  1.000 21.44339 ? 112 ASP   B OD1 1 
ATOM   1945 O OD2 . ASP   B 1 115 ? 24.10583  -11.86814 0.06170   1.000 20.18555 ? 112 ASP   B OD2 1 
ATOM   1946 N N   . CYS   B 1 116 ? 20.90947  -7.21372  -1.90820  1.000 24.69421 ? 113 CYS   B N   1 
ATOM   1947 C CA  . CYS   B 1 116 ? 19.98459  -6.12794  -1.62743  1.000 25.57821 ? 113 CYS   B CA  1 
ATOM   1948 C C   . CYS   B 1 116 ? 19.44086  -5.54857  -2.92584  1.000 25.97080 ? 113 CYS   B C   1 
ATOM   1949 O O   . CYS   B 1 116 ? 20.15438  -5.48064  -3.92594  1.000 27.39845 ? 113 CYS   B O   1 
ATOM   1950 C CB  . CYS   B 1 116 ? 20.70195  -5.03415  -0.84932  1.000 29.37267 ? 113 CYS   B CB  1 
ATOM   1951 S SG  . CYS   B 1 116 ? 19.61547  -3.89070  -0.11728  1.000 37.15880 ? 113 CYS   B SG  1 
ATOM   1952 N N   . SER   B 1 117 ? 18.18566  -5.08439  -2.88981  1.000 29.58115 ? 114 SER   B N   1 
ATOM   1953 C CA  . SER   B 1 117 ? 17.59280  -4.44502  -4.06655  1.000 27.76253 ? 114 SER   B CA  1 
ATOM   1954 C C   . SER   B 1 117 ? 18.29763  -3.13964  -4.42048  1.000 32.29035 ? 114 SER   B C   1 
ATOM   1955 O O   . SER   B 1 117 ? 18.27254  -2.71502  -5.58299  1.000 32.84707 ? 114 SER   B O   1 
ATOM   1956 C CB  . SER   B 1 117 ? 16.10672  -4.18351  -3.83835  1.000 38.61358 ? 114 SER   B CB  1 
ATOM   1957 O OG  . SER   B 1 117 ? 15.92954  -3.30417  -2.74196  1.000 46.37011 ? 114 SER   B OG  1 
ATOM   1958 N N   . SER   B 1 118 ? 18.92747  -2.48828  -3.44433  1.000 30.75957 ? 115 SER   B N   1 
ATOM   1959 C CA  . SER   B 1 118 ? 19.67272  -1.27263  -3.73935  1.000 29.61550 ? 115 SER   B CA  1 
ATOM   1960 C C   . SER   B 1 118 ? 20.97988  -1.54513  -4.47620  1.000 26.13681 ? 115 SER   B C   1 
ATOM   1961 O O   . SER   B 1 118 ? 21.67139  -0.58516  -4.84617  1.000 27.43181 ? 115 SER   B O   1 
ATOM   1962 C CB  . SER   B 1 118 ? 19.93968  -0.49648  -2.44670  1.000 24.72637 ? 115 SER   B CB  1 
ATOM   1963 O OG  . SER   B 1 118 ? 20.75982  -1.23649  -1.55800  1.000 27.30800 ? 115 SER   B OG  1 
ATOM   1964 N N   . ALA   B 1 119 ? 21.33303  -2.81225  -4.71512  1.000 24.71009 ? 116 ALA   B N   1 
ATOM   1965 C CA  . ALA   B 1 119 ? 22.49349  -3.08716  -5.55778  1.000 27.16268 ? 116 ALA   B CA  1 
ATOM   1966 C C   . ALA   B 1 119 ? 22.32236  -2.46893  -6.93781  1.000 31.65459 ? 116 ALA   B C   1 
ATOM   1967 O O   . ALA   B 1 119 ? 23.30985  -2.07938  -7.57078  1.000 30.14461 ? 116 ALA   B O   1 
ATOM   1968 C CB  . ALA   B 1 119 ? 22.72905  -4.59414  -5.67408  1.000 29.64478 ? 116 ALA   B CB  1 
ATOM   1969 N N   . LYS   B 1 120 ? 21.07745  -2.35313  -7.40932  1.000 27.61925 ? 117 LYS   B N   1 
ATOM   1970 C CA  . LYS   B 1 120 ? 20.78993  -1.70543  -8.68388  1.000 33.45653 ? 117 LYS   B CA  1 
ATOM   1971 C C   . LYS   B 1 120 ? 20.99659  -0.19984  -8.63951  1.000 36.39556 ? 117 LYS   B C   1 
ATOM   1972 O O   . LYS   B 1 120 ? 20.92029  0.44948   -9.68895  1.000 35.54172 ? 117 LYS   B O   1 
ATOM   1973 C CB  . LYS   B 1 120 ? 19.35119  -2.00623  -9.11616  1.000 35.52239 ? 117 LYS   B CB  1 
ATOM   1974 C CG  . LYS   B 1 120 ? 19.09120  -3.47278  -9.39098  1.000 40.91791 ? 117 LYS   B CG  1 
ATOM   1975 C CD  . LYS   B 1 120 ? 17.77873  -3.68813  -10.12677 1.000 39.58419 ? 117 LYS   B CD  1 
ATOM   1976 C CE  . LYS   B 1 120 ? 16.57854  -3.42103  -9.23632  1.000 42.42977 ? 117 LYS   B CE  1 
ATOM   1977 N NZ  . LYS   B 1 120 ? 15.29685  -3.70612  -9.95502  1.000 43.83181 ? 117 LYS   B NZ  1 
ATOM   1978 N N   . ALA   B 1 121 ? 21.24887  0.36516   -7.46393  1.000 28.54289 ? 118 ALA   B N   1 
ATOM   1979 C CA  . ALA   B 1 121 ? 21.42616  1.79948   -7.28970  1.000 32.33506 ? 118 ALA   B CA  1 
ATOM   1980 C C   . ALA   B 1 121 ? 22.74368  2.08808   -6.59845  1.000 29.50237 ? 118 ALA   B C   1 
ATOM   1981 O O   . ALA   B 1 121 ? 22.80128  2.90419   -5.67712  1.000 32.62443 ? 118 ALA   B O   1 
ATOM   1982 C CB  . ALA   B 1 121 ? 20.26980  2.40906   -6.49994  1.000 30.00221 ? 118 ALA   B CB  1 
ATOM   1983 N N   . ARG   B 1 122 ? 23.81084  1.39361   -7.02882  1.000 24.49863 ? 119 ARG   B N   1 
ATOM   1984 C CA  . ARG   B 1 122 ? 25.18528  1.49688   -6.50967  1.000 25.23640 ? 119 ARG   B CA  1 
ATOM   1985 C C   . ARG   B 1 122 ? 25.26227  1.32792   -4.99245  1.000 23.61036 ? 119 ARG   B C   1 
ATOM   1986 O O   . ARG   B 1 122 ? 26.24569  1.74326   -4.36988  1.000 26.66260 ? 119 ARG   B O   1 
ATOM   1987 C CB  . ARG   B 1 122 ? 25.86294  2.81304   -6.93059  1.000 29.25279 ? 119 ARG   B CB  1 
ATOM   1988 C CG  . ARG   B 1 122 ? 25.39204  4.04169   -6.17550  1.000 28.82488 ? 119 ARG   B CG  1 
ATOM   1989 C CD  . ARG   B 1 122 ? 25.88759  5.34552   -6.76512  1.000 39.43219 ? 119 ARG   B CD  1 
ATOM   1990 N NE  . ARG   B 1 122 ? 25.24383  6.45937   -6.08469  1.000 35.82350 ? 119 ARG   B NE  1 
ATOM   1991 C CZ  . ARG   B 1 122 ? 24.01131  6.86641   -6.35154  1.000 29.89916 ? 119 ARG   B CZ  1 
ATOM   1992 N NH1 . ARG   B 1 122 ? 23.30229  6.32367   -7.33068  1.000 34.39974 ? 119 ARG   B NH1 1 
ATOM   1993 N NH2 . ARG   B 1 122 ? 23.47216  7.83146   -5.61285  1.000 29.00555 ? 119 ARG   B NH2 1 
ATOM   1994 N N   . GLY   B 1 123 ? 24.26455  0.68483   -4.38723  1.000 21.35897 ? 120 GLY   B N   1 
ATOM   1995 C CA  . GLY   B 1 123 ? 24.25037  0.47191   -2.95290  1.000 20.92306 ? 120 GLY   B CA  1 
ATOM   1996 C C   . GLY   B 1 123 ? 23.62027  1.58377   -2.14112  1.000 18.23807 ? 120 GLY   B C   1 
ATOM   1997 O O   . GLY   B 1 123 ? 23.56614  1.47877   -0.90698  1.000 16.75630 ? 120 GLY   B O   1 
ATOM   1998 N N   . ASP   B 1 124 ? 23.14253  2.63929   -2.79386  1.000 19.19428 ? 121 ASP   B N   1 
ATOM   1999 C CA  . ASP   B 1 124 ? 22.62664  3.81014   -2.10166  1.000 18.71151 ? 121 ASP   B CA  1 
ATOM   2000 C C   . ASP   B 1 124 ? 21.37378  3.47384   -1.30115  1.000 19.54571 ? 121 ASP   B C   1 
ATOM   2001 O O   . ASP   B 1 124 ? 20.42887  2.87643   -1.82664  1.000 22.55922 ? 121 ASP   B O   1 
ATOM   2002 C CB  . ASP   B 1 124 ? 22.33008  4.90262   -3.13555  1.000 19.91888 ? 121 ASP   B CB  1 
ATOM   2003 C CG  . ASP   B 1 124 ? 21.76448  6.16850   -2.52025  1.000 19.10342 ? 121 ASP   B CG  1 
ATOM   2004 O OD1 . ASP   B 1 124 ? 22.23605  6.58025   -1.43778  1.000 17.27098 ? 121 ASP   B OD1 1 
ATOM   2005 O OD2 . ASP   B 1 124 ? 20.86476  6.77302   -3.15003  1.000 20.14569 ? 121 ASP   B OD2 1 
ATOM   2006 N N   . LEU   B 1 125 ? 21.37485  3.86888   -0.02065  1.000 18.91640 ? 122 LEU   B N   1 
ATOM   2007 C CA  . LEU   B 1 125 ? 20.22118  3.74703   0.86446   1.000 18.14059 ? 122 LEU   B CA  1 
ATOM   2008 C C   . LEU   B 1 125 ? 19.44577  5.04570   1.01414   1.000 20.82625 ? 122 LEU   B C   1 
ATOM   2009 O O   . LEU   B 1 125 ? 18.35637  5.03528   1.59844   1.000 23.31402 ? 122 LEU   B O   1 
ATOM   2010 C CB  . LEU   B 1 125 ? 20.65875  3.28641   2.26261   1.000 24.81437 ? 122 LEU   B CB  1 
ATOM   2011 C CG  . LEU   B 1 125 ? 21.27519  1.90454   2.35615   1.000 30.47755 ? 122 LEU   B CG  1 
ATOM   2012 C CD1 . LEU   B 1 125 ? 21.40883  1.48168   3.80716   1.000 31.42036 ? 122 LEU   B CD1 1 
ATOM   2013 C CD2 . LEU   B 1 125 ? 20.38805  0.96072   1.61052   1.000 30.34271 ? 122 LEU   B CD2 1 
ATOM   2014 N N   . GLY   B 1 126 ? 19.97744  6.15562   0.50940   1.000 19.61519 ? 123 GLY   B N   1 
ATOM   2015 C CA  . GLY   B 1 126 ? 19.38261  7.45002   0.74563   1.000 19.16470 ? 123 GLY   B CA  1 
ATOM   2016 C C   . GLY   B 1 126 ? 19.71016  7.95884   2.13387   1.000 19.36495 ? 123 GLY   B C   1 
ATOM   2017 O O   . GLY   B 1 126 ? 20.45233  7.34735   2.90794   1.000 19.13387 ? 123 GLY   B O   1 
ATOM   2018 N N   . ALA   B 1 127 ? 19.13150  9.11253   2.44789   1.000 23.81215 ? 124 ALA   B N   1 
ATOM   2019 C CA  . ALA   B 1 127 ? 19.36843  9.79398   3.70986   1.000 22.96480 ? 124 ALA   B CA  1 
ATOM   2020 C C   . ALA   B 1 127 ? 18.42761  9.27285   4.78768   1.000 23.18875 ? 124 ALA   B C   1 
ATOM   2021 O O   . ALA   B 1 127 ? 17.30097  8.84908   4.50599   1.000 27.13135 ? 124 ALA   B O   1 
ATOM   2022 C CB  . ALA   B 1 127 ? 19.18823  11.30259  3.54191   1.000 23.30542 ? 124 ALA   B CB  1 
ATOM   2023 N N   . PHE   B 1 128 ? 18.89731  9.30838   6.03276   1.000 20.69655 ? 125 PHE   B N   1 
ATOM   2024 C CA  . PHE   B 1 128 ? 18.08670  8.83651   7.14744   1.000 22.14150 ? 125 PHE   B CA  1 
ATOM   2025 C C   . PHE   B 1 128 ? 18.55016  9.48667   8.44139   1.000 22.63105 ? 125 PHE   B C   1 
ATOM   2026 O O   . PHE   B 1 128 ? 19.68605  9.95491   8.55991   1.000 21.63198 ? 125 PHE   B O   1 
ATOM   2027 C CB  . PHE   B 1 128 ? 18.13346  7.30786   7.27708   1.000 22.25764 ? 125 PHE   B CB  1 
ATOM   2028 C CG  . PHE   B 1 128 ? 19.52241  6.75270   7.43802   1.000 20.26322 ? 125 PHE   B CG  1 
ATOM   2029 C CD1 . PHE   B 1 128 ? 20.28296  6.42051   6.32144   1.000 21.83891 ? 125 PHE   B CD1 1 
ATOM   2030 C CD2 . PHE   B 1 128 ? 20.06713  6.56563   8.69744   1.000 19.26983 ? 125 PHE   B CD2 1 
ATOM   2031 C CE1 . PHE   B 1 128 ? 21.57054  5.90248   6.46286   1.000 19.35755 ? 125 PHE   B CE1 1 
ATOM   2032 C CE2 . PHE   B 1 128 ? 21.34482  6.05874   8.84455   1.000 19.55918 ? 125 PHE   B CE2 1 
ATOM   2033 C CZ  . PHE   B 1 128 ? 22.09394  5.71283   7.72171   1.000 20.72861 ? 125 PHE   B CZ  1 
ATOM   2034 N N   . SER   B 1 129 ? 17.65245  9.50169   9.41618   1.000 19.85932 ? 126 SER   B N   1 
ATOM   2035 C CA  . SER   B 1 129 ? 17.95656  10.01136  10.74232  1.000 20.29665 ? 126 SER   B CA  1 
ATOM   2036 C C   . SER   B 1 129 ? 18.04481  8.84484   11.71623  1.000 17.06338 ? 126 SER   B C   1 
ATOM   2037 O O   . SER   B 1 129 ? 17.86481  7.67766   11.35026  1.000 20.10894 ? 126 SER   B O   1 
ATOM   2038 C CB  . SER   B 1 129 ? 16.89556  11.01743  11.18886  1.000 23.52517 ? 126 SER   B CB  1 
ATOM   2039 O OG  . SER   B 1 129 ? 15.65743  10.36059  11.37205  1.000 30.16814 ? 126 SER   B OG  1 
ATOM   2040 N N   . ARG   B 1 130 ? 18.32735  9.15789   12.97630  1.000 18.66109 ? 127 ARG   B N   1 
ATOM   2041 C CA  . ARG   B 1 130 ? 18.32572  8.10742   13.97985  1.000 19.96025 ? 127 ARG   B CA  1 
ATOM   2042 C C   . ARG   B 1 130 ? 16.91580  7.55684   14.17070  1.000 17.97267 ? 127 ARG   B C   1 
ATOM   2043 O O   . ARG   B 1 130 ? 15.91121  8.24383   13.94862  1.000 25.13389 ? 127 ARG   B O   1 
ATOM   2044 C CB  . ARG   B 1 130 ? 18.89499  8.61824   15.30621  1.000 22.00340 ? 127 ARG   B CB  1 
ATOM   2045 C CG  . ARG   B 1 130 ? 20.41292  8.80982   15.23973  1.000 21.75187 ? 127 ARG   B CG  1 
ATOM   2046 C CD  . ARG   B 1 130 ? 21.06449  8.83354   16.60838  1.000 26.93666 ? 127 ARG   B CD  1 
ATOM   2047 N NE  . ARG   B 1 130 ? 22.50804  9.03449   16.52350  1.000 24.82625 ? 127 ARG   B NE  1 
ATOM   2048 C CZ  . ARG   B 1 130 ? 23.40677  8.05746   16.53440  1.000 24.85817 ? 127 ARG   B CZ  1 
ATOM   2049 N NH1 . ARG   B 1 130 ? 23.04712  6.78504   16.58908  1.000 26.05317 ? 127 ARG   B NH1 1 
ATOM   2050 N NH2 . ARG   B 1 130 ? 24.70233  8.36610   16.50109  1.000 26.39396 ? 127 ARG   B NH2 1 
ATOM   2051 N N   . GLY   B 1 131 ? 16.85680  6.29420   14.56520  1.000 20.03622 ? 128 GLY   B N   1 
ATOM   2052 C CA  . GLY   B 1 131 ? 15.59776  5.62927   14.82981  1.000 18.52408 ? 128 GLY   B CA  1 
ATOM   2053 C C   . GLY   B 1 131 ? 14.93039  4.99269   13.63585  1.000 19.38843 ? 128 GLY   B C   1 
ATOM   2054 O O   . GLY   B 1 131 ? 13.72525  4.70994   13.69973  1.000 19.54479 ? 128 GLY   B O   1 
ATOM   2055 N N   . GLN   B 1 132 ? 15.65841  4.76575   12.54005  1.000 16.46401 ? 129 GLN   B N   1 
ATOM   2056 C CA  . GLN   B 1 132 ? 15.10745  4.05432   11.39157  1.000 14.87009 ? 129 GLN   B CA  1 
ATOM   2057 C C   . GLN   B 1 132 ? 15.87019  2.78054   11.06740  1.000 16.02034 ? 129 GLN   B C   1 
ATOM   2058 O O   . GLN   B 1 132 ? 15.25769  1.71915   10.91967  1.000 19.35408 ? 129 GLN   B O   1 
ATOM   2059 C CB  . GLN   B 1 132 ? 15.08037  4.93867   10.13328  1.000 16.71630 ? 129 GLN   B CB  1 
ATOM   2060 C CG  . GLN   B 1 132 ? 14.59861  4.12738   8.91142   1.000 22.37977 ? 129 GLN   B CG  1 
ATOM   2061 C CD  . GLN   B 1 132 ? 14.27352  4.97428   7.70908   1.000 28.46590 ? 129 GLN   B CD  1 
ATOM   2062 O OE1 . GLN   B 1 132 ? 15.05033  5.84452   7.31933   1.000 26.65124 ? 129 GLN   B OE1 1 
ATOM   2063 N NE2 . GLN   B 1 132 ? 13.11204  4.72296   7.10553   1.000 30.06381 ? 129 GLN   B NE2 1 
ATOM   2064 N N   . MET   B 1 133 ? 17.19102  2.86082   10.91505  1.000 16.55453 ? 130 MET   B N   1 
ATOM   2065 C CA  . MET   B 1 133 ? 18.00873  1.68855   10.64087  1.000 17.74203 ? 130 MET   B CA  1 
ATOM   2066 C C   . MET   B 1 133 ? 18.36303  0.98232   11.94269  1.000 17.47670 ? 130 MET   B C   1 
ATOM   2067 O O   . MET   B 1 133 ? 18.41232  1.60061   13.00730  1.000 20.99927 ? 130 MET   B O   1 
ATOM   2068 C CB  . MET   B 1 133 ? 19.29878  2.09421   9.92605   1.000 15.82369 ? 130 MET   B CB  1 
ATOM   2069 C CG  . MET   B 1 133 ? 19.07037  3.03202   8.77640   1.000 18.84518 ? 130 MET   B CG  1 
ATOM   2070 S SD  . MET   B 1 133 ? 18.05489  2.25380   7.52309   1.000 19.72816 ? 130 MET   B SD  1 
ATOM   2071 C CE  . MET   B 1 133 ? 17.98380  3.58271   6.32018   1.000 25.22151 ? 130 MET   B CE  1 
ATOM   2072 N N   . GLN   B 1 134 ? 18.65094  -0.31630  11.84772  1.000 15.97847 ? 131 GLN   B N   1 
ATOM   2073 C CA  . GLN   B 1 134 ? 19.00512  -1.06525  13.04917  1.000 16.97399 ? 131 GLN   B CA  1 
ATOM   2074 C C   . GLN   B 1 134 ? 20.22533  -0.44304  13.71979  1.000 18.40838 ? 131 GLN   B C   1 
ATOM   2075 O O   . GLN   B 1 134 ? 21.13677  0.04746   13.05006  1.000 17.76941 ? 131 GLN   B O   1 
ATOM   2076 C CB  . GLN   B 1 134 ? 19.28002  -2.52750  12.71835  1.000 18.02654 ? 131 GLN   B CB  1 
ATOM   2077 C CG  . GLN   B 1 134 ? 19.28891  -3.39603  13.96520  1.000 25.66448 ? 131 GLN   B CG  1 
ATOM   2078 C CD  . GLN   B 1 134 ? 19.69435  -4.82088  13.68511  1.000 22.80308 ? 131 GLN   B CD  1 
ATOM   2079 O OE1 . GLN   B 1 134 ? 19.37316  -5.37559  12.64040  1.000 22.61951 ? 131 GLN   B OE1 1 
ATOM   2080 N NE2 . GLN   B 1 134 ? 20.40964  -5.42534  14.62671  1.000 33.25689 ? 131 GLN   B NE2 1 
ATOM   2081 N N   . LYS   B 1 135 ? 20.22912  -0.47002  15.05601  1.000 19.06951 ? 132 LYS   B N   1 
ATOM   2082 C CA  . LYS   B 1 135 ? 21.19320  0.28303   15.86268  1.000 17.75679 ? 132 LYS   B CA  1 
ATOM   2083 C C   . LYS   B 1 135 ? 22.65004  0.12580   15.43309  1.000 17.91335 ? 132 LYS   B C   1 
ATOM   2084 O O   . LYS   B 1 135 ? 23.34021  1.15031   15.31747  1.000 18.45616 ? 132 LYS   B O   1 
ATOM   2085 C CB  . LYS   B 1 135 ? 21.01503  -0.11183  17.33755  1.000 22.18758 ? 132 LYS   B CB  1 
ATOM   2086 C CG  . LYS   B 1 135 ? 21.88255  0.66704   18.30465  1.000 31.33440 ? 132 LYS   B CG  1 
ATOM   2087 C CD  . LYS   B 1 135 ? 21.46479  2.12391   18.35364  1.000 34.06570 ? 132 LYS   B CD  1 
ATOM   2088 C CE  . LYS   B 1 135 ? 21.76599  2.72620   19.72225  1.000 39.50256 ? 132 LYS   B CE  1 
ATOM   2089 N NZ  . LYS   B 1 135 ? 23.12737  2.35192   20.20923  1.000 36.87592 ? 132 LYS   B NZ  1 
ATOM   2090 N N   . PRO   B 1 136 ? 23.18884  -1.08183  15.20065  1.000 19.33070 ? 133 PRO   B N   1 
ATOM   2091 C CA  . PRO   B 1 136 ? 24.61045  -1.15575  14.81345  1.000 16.85770 ? 133 PRO   B CA  1 
ATOM   2092 C C   . PRO   B 1 136 ? 24.88287  -0.42549  13.51550  1.000 17.74520 ? 133 PRO   B C   1 
ATOM   2093 O O   . PRO   B 1 136 ? 25.91057  0.25185   13.38179  1.000 18.05931 ? 133 PRO   B O   1 
ATOM   2094 C CB  . PRO   B 1 136 ? 24.86685  -2.66326  14.68703  1.000 18.20499 ? 133 PRO   B CB  1 
ATOM   2095 C CG  . PRO   B 1 136 ? 23.79227  -3.31299  15.48208  1.000 20.88511 ? 133 PRO   B CG  1 
ATOM   2096 C CD  . PRO   B 1 136 ? 22.59295  -2.42586  15.31098  1.000 16.38374 ? 133 PRO   B CD  1 
ATOM   2097 N N   . PHE   B 1 137 ? 23.95428  -0.51938  12.56268  1.000 15.43076 ? 134 PHE   B N   1 
ATOM   2098 C CA  . PHE   B 1 137 ? 24.11484  0.18027   11.29139  1.000 14.49075 ? 134 PHE   B CA  1 
ATOM   2099 C C   . PHE   B 1 137 ? 24.00319  1.68682   11.48157  1.000 16.62842 ? 134 PHE   B C   1 
ATOM   2100 O O   . PHE   B 1 137 ? 24.80917  2.45331   10.94012  1.000 16.65564 ? 134 PHE   B O   1 
ATOM   2101 C CB  . PHE   B 1 137 ? 23.07315  -0.33207  10.29095  1.000 14.54551 ? 134 PHE   B CB  1 
ATOM   2102 C CG  . PHE   B 1 137 ? 23.29867  0.14414   8.88024   1.000 14.85515 ? 134 PHE   B CG  1 
ATOM   2103 C CD1 . PHE   B 1 137 ? 22.91881  1.42521   8.49160   1.000 16.90918 ? 134 PHE   B CD1 1 
ATOM   2104 C CD2 . PHE   B 1 137 ? 23.89130  -0.69244  7.94043   1.000 15.00706 ? 134 PHE   B CD2 1 
ATOM   2105 C CE1 . PHE   B 1 137 ? 23.13273  1.86467   7.19672   1.000 14.62525 ? 134 PHE   B CE1 1 
ATOM   2106 C CE2 . PHE   B 1 137 ? 24.10568  -0.25789  6.64192   1.000 15.20686 ? 134 PHE   B CE2 1 
ATOM   2107 C CZ  . PHE   B 1 137 ? 23.73000  1.01528   6.27142   1.000 15.56672 ? 134 PHE   B CZ  1 
ATOM   2108 N N   . GLU   B 1 138 ? 23.00927  2.12711   12.25817  1.000 16.39224 ? 135 GLU   B N   1 
ATOM   2109 C CA  . GLU   B 1 138 ? 22.84643  3.54155   12.56062  1.000 16.73964 ? 135 GLU   B CA  1 
ATOM   2110 C C   . GLU   B 1 138 ? 24.07212  4.09949   13.27289  1.000 16.96875 ? 135 GLU   B C   1 
ATOM   2111 O O   . GLU   B 1 138 ? 24.59865  5.15341   12.89472  1.000 18.12977 ? 135 GLU   B O   1 
ATOM   2112 C CB  . GLU   B 1 138 ? 21.58966  3.72995   13.41704  1.000 18.97079 ? 135 GLU   B CB  1 
ATOM   2113 C CG  . GLU   B 1 138 ? 21.51134  5.06376   14.10235  1.000 24.58779 ? 135 GLU   B CG  1 
ATOM   2114 C CD  . GLU   B 1 138 ? 20.31145  5.13814   15.01699  1.000 21.95623 ? 135 GLU   B CD  1 
ATOM   2115 O OE1 . GLU   B 1 138 ? 19.20806  4.83375   14.53568  1.000 19.72516 ? 135 GLU   B OE1 1 
ATOM   2116 O OE2 . GLU   B 1 138 ? 20.48612  5.47651   16.20660  1.000 25.03700 ? 135 GLU   B OE2 1 
ATOM   2117 N N   . ASP   B 1 139 ? 24.54860  3.39394   14.30253  1.000 17.55641 ? 136 ASP   B N   1 
ATOM   2118 C CA  . ASP   B 1 139 ? 25.68520  3.88701   15.07116  1.000 16.34106 ? 136 ASP   B CA  1 
ATOM   2119 C C   . ASP   B 1 139 ? 26.92621  4.00594   14.19666  1.000 17.52302 ? 136 ASP   B C   1 
ATOM   2120 O O   . ASP   B 1 139 ? 27.63648  5.01751   14.24988  1.000 20.26262 ? 136 ASP   B O   1 
ATOM   2121 C CB  . ASP   B 1 139 ? 25.95535  2.96562   16.26032  1.000 16.49399 ? 136 ASP   B CB  1 
ATOM   2122 C CG  . ASP   B 1 139 ? 24.97273  3.16360   17.39859  1.000 23.08405 ? 136 ASP   B CG  1 
ATOM   2123 O OD1 . ASP   B 1 139 ? 24.22166  4.15756   17.38406  1.000 22.29133 ? 136 ASP   B OD1 1 
ATOM   2124 O OD2 . ASP   B 1 139 ? 24.96704  2.31294   18.30913  1.000 23.76677 ? 136 ASP   B OD2 1 
ATOM   2125 N N   . ALA   B 1 140 ? 27.20158  2.99019   13.37914  1.000 15.98029 ? 137 ALA   B N   1 
ATOM   2126 C CA  . ALA   B 1 140 ? 28.35377  3.08660   12.48317  1.000 16.78265 ? 137 ALA   B CA  1 
ATOM   2127 C C   . ALA   B 1 140 ? 28.20117  4.24489   11.49995  1.000 17.80720 ? 137 ALA   B C   1 
ATOM   2128 O O   . ALA   B 1 140 ? 29.14742  5.01515   11.28428  1.000 20.68244 ? 137 ALA   B O   1 
ATOM   2129 C CB  . ALA   B 1 140 ? 28.56539  1.76651   11.74776  1.000 15.07787 ? 137 ALA   B CB  1 
ATOM   2130 N N   . SER   B 1 141 ? 27.00888  4.40359   10.91156  1.000 15.34166 ? 138 SER   B N   1 
ATOM   2131 C CA  . SER   B 1 141 ? 26.80379  5.43207   9.89290   1.000 17.49763 ? 138 SER   B CA  1 
ATOM   2132 C C   . SER   B 1 141 ? 27.07625  6.82287   10.44426  1.000 19.70610 ? 138 SER   B C   1 
ATOM   2133 O O   . SER   B 1 141 ? 27.73427  7.64346   9.79334   1.000 20.14712 ? 138 SER   B O   1 
ATOM   2134 C CB  . SER   B 1 141 ? 25.37622  5.34732   9.34791   1.000 14.51100 ? 138 SER   B CB  1 
ATOM   2135 O OG  . SER   B 1 141 ? 25.13871  4.12573   8.68092   1.000 16.20837 ? 138 SER   B OG  1 
ATOM   2136 N N   . PHE   B 1 142 ? 26.56413  7.11560   11.64186  1.000 19.29132 ? 139 PHE   B N   1 
ATOM   2137 C CA  . PHE   B 1 142 ? 26.75326  8.44602   12.20723  1.000 16.94163 ? 139 PHE   B CA  1 
ATOM   2138 C C   . PHE   B 1 142 ? 28.16492  8.65230   12.73886  1.000 18.47370 ? 139 PHE   B C   1 
ATOM   2139 O O   . PHE   B 1 142 ? 28.59794  9.80216   12.86695  1.000 24.62516 ? 139 PHE   B O   1 
ATOM   2140 C CB  . PHE   B 1 142 ? 25.71463  8.70532   13.30456  1.000 22.07713 ? 139 PHE   B CB  1 
ATOM   2141 C CG  . PHE   B 1 142 ? 24.38129  9.13912   12.76803  1.000 18.33499 ? 139 PHE   B CG  1 
ATOM   2142 C CD1 . PHE   B 1 142 ? 23.41399  8.20807   12.43843  1.000 16.99167 ? 139 PHE   B CD1 1 
ATOM   2143 C CD2 . PHE   B 1 142 ? 24.10315  10.48007  12.57590  1.000 23.08511 ? 139 PHE   B CD2 1 
ATOM   2144 C CE1 . PHE   B 1 142 ? 22.18731  8.60498   11.92609  1.000 19.53212 ? 139 PHE   B CE1 1 
ATOM   2145 C CE2 . PHE   B 1 142 ? 22.87869  10.88167  12.06939  1.000 20.58537 ? 139 PHE   B CE2 1 
ATOM   2146 C CZ  . PHE   B 1 142 ? 21.92245  9.94227   11.74611  1.000 19.37023 ? 139 PHE   B CZ  1 
ATOM   2147 N N   . ALA   B 1 143 ? 28.89357  7.57584   13.03531  1.000 18.41595 ? 140 ALA   B N   1 
ATOM   2148 C CA  . ALA   B 1 143 ? 30.27102  7.71652   13.49182  1.000 18.59034 ? 140 ALA   B CA  1 
ATOM   2149 C C   . ALA   B 1 143 ? 31.26009  7.84436   12.34429  1.000 27.13955 ? 140 ALA   B C   1 
ATOM   2150 O O   . ALA   B 1 143 ? 32.41033  8.23265   12.58548  1.000 23.96301 ? 140 ALA   B O   1 
ATOM   2151 C CB  . ALA   B 1 143 ? 30.66121  6.53536   14.37557  1.000 20.51685 ? 140 ALA   B CB  1 
ATOM   2152 N N   . LEU   B 1 144 ? 30.85054  7.52459   11.11714  1.000 21.10759 ? 141 LEU   B N   1 
ATOM   2153 C CA  . LEU   B 1 144 ? 31.70590  7.74381   9.95757   1.000 16.78178 ? 141 LEU   B CA  1 
ATOM   2154 C C   . LEU   B 1 144 ? 31.77340  9.22406   9.60636   1.000 20.02080 ? 141 LEU   B C   1 
ATOM   2155 O O   . LEU   B 1 144 ? 30.81935  9.97584   9.80521   1.000 22.12620 ? 141 LEU   B O   1 
ATOM   2156 C CB  . LEU   B 1 144 ? 31.18643  6.96659   8.74556   1.000 16.95969 ? 141 LEU   B CB  1 
ATOM   2157 C CG  . LEU   B 1 144 ? 31.28357  5.44294   8.79774   1.000 16.17146 ? 141 LEU   B CG  1 
ATOM   2158 C CD1 . LEU   B 1 144 ? 30.40453  4.80774   7.71550   1.000 16.57090 ? 141 LEU   B CD1 1 
ATOM   2159 C CD2 . LEU   B 1 144 ? 32.73374  4.98837   8.63873   1.000 16.82383 ? 141 LEU   B CD2 1 
ATOM   2160 N N   . ARG   B 1 145 ? 32.92000  9.64370   9.07735   1.000 23.02049 ? 142 ARG   B N   1 
ATOM   2161 C CA  . ARG   B 1 145 ? 32.97771  10.93712  8.41702   1.000 25.07077 ? 142 ARG   B CA  1 
ATOM   2162 C C   . ARG   B 1 145 ? 32.54735  10.76865  6.96400   1.000 20.50274 ? 142 ARG   B C   1 
ATOM   2163 O O   . ARG   B 1 145 ? 32.60972  9.67211   6.39701   1.000 20.42877 ? 142 ARG   B O   1 
ATOM   2164 C CB  . ARG   B 1 145 ? 34.38479  11.54582  8.48758   1.000 30.27795 ? 142 ARG   B CB  1 
ATOM   2165 C CG  . ARG   B 1 145 ? 34.98021  11.61129  9.89043   1.000 38.61896 ? 142 ARG   B CG  1 
ATOM   2166 C CD  . ARG   B 1 145 ? 34.96509  13.02262  10.45373  1.000 46.53643 ? 142 ARG   B CD  1 
ATOM   2167 N NE  . ARG   B 1 145 ? 35.71923  13.94753  9.61507   1.000 58.72872 ? 142 ARG   B NE  1 
ATOM   2168 C CZ  . ARG   B 1 145 ? 36.37980  15.00485  10.06835  1.000 62.73830 ? 142 ARG   B CZ  1 
ATOM   2169 N NH1 . ARG   B 1 145 ? 36.43072  15.28734  11.36003  1.000 68.37286 ? 142 ARG   B NH1 1 
ATOM   2170 N NH2 . ARG   B 1 145 ? 37.01286  15.79386  9.20461   1.000 65.94666 ? 142 ARG   B NH2 1 
ATOM   2171 N N   . THR   B 1 146 ? 32.09248  11.86700  6.36391   1.000 20.52230 ? 143 THR   B N   1 
ATOM   2172 C CA  . THR   B 1 146 ? 31.68947  11.82420  4.96374   1.000 18.89952 ? 143 THR   B CA  1 
ATOM   2173 C C   . THR   B 1 146 ? 32.84351  11.32684  4.10310   1.000 24.13638 ? 143 THR   B C   1 
ATOM   2174 O O   . THR   B 1 146 ? 33.97913  11.78326  4.24910   1.000 24.37248 ? 143 THR   B O   1 
ATOM   2175 C CB  . THR   B 1 146 ? 31.23750  13.20618  4.49699   1.000 28.69138 ? 143 THR   B CB  1 
ATOM   2176 O OG1 . THR   B 1 146 ? 30.09297  13.61038  5.25732   1.000 30.70718 ? 143 THR   B OG1 1 
ATOM   2177 C CG2 . THR   B 1 146 ? 30.85859  13.17061  3.03084   1.000 27.23142 ? 143 THR   B CG2 1 
ATOM   2178 N N   . GLY   B 1 147 ? 32.55291  10.37147  3.22029   1.000 20.44168 ? 144 GLY   B N   1 
ATOM   2179 C CA  . GLY   B 1 147 ? 33.55779  9.75263   2.38192   1.000 22.88673 ? 144 GLY   B CA  1 
ATOM   2180 C C   . GLY   B 1 147 ? 34.26941  8.56350   2.99187   1.000 23.74519 ? 144 GLY   B C   1 
ATOM   2181 O O   . GLY   B 1 147 ? 35.04268  7.90407   2.28721   1.000 28.31240 ? 144 GLY   B O   1 
ATOM   2182 N N   . GLU   B 1 148 ? 34.05642  8.28505   4.27857   1.000 23.05657 ? 145 GLU   B N   1 
ATOM   2183 C CA  . GLU   B 1 148 ? 34.71858  7.19139   4.97698   1.000 22.79137 ? 145 GLU   B CA  1 
ATOM   2184 C C   . GLU   B 1 148 ? 33.91151  5.90284   4.86836   1.000 18.93829 ? 145 GLU   B C   1 
ATOM   2185 O O   . GLU   B 1 148 ? 32.68752  5.91373   4.70487   1.000 20.37625 ? 145 GLU   B O   1 
ATOM   2186 C CB  . GLU   B 1 148 ? 34.92428  7.51005   6.45998   1.000 28.31163 ? 145 GLU   B CB  1 
ATOM   2187 C CG  . GLU   B 1 148 ? 36.06177  8.45485   6.79002   1.000 33.70307 ? 145 GLU   B CG  1 
ATOM   2188 C CD  . GLU   B 1 148 ? 36.21059  8.66975   8.29024   1.000 40.21485 ? 145 GLU   B CD  1 
ATOM   2189 O OE1 . GLU   B 1 148 ? 35.40823  8.09511   9.06985   1.000 28.57867 ? 145 GLU   B OE1 1 
ATOM   2190 O OE2 . GLU   B 1 148 ? 37.12817  9.41669   8.69103   1.000 44.96110 ? 145 GLU   B OE2 1 
ATOM   2191 N N   . MET   B 1 149 ? 34.61459  4.78476   5.01364   1.000 20.61655 ? 146 MET   B N   1 
ATOM   2192 C CA  . MET   B 1 149 ? 34.03837  3.45680   4.88670   1.000 17.89879 ? 146 MET   B CA  1 
ATOM   2193 C C   . MET   B 1 149 ? 34.21804  2.69630   6.19395   1.000 20.39474 ? 146 MET   B C   1 
ATOM   2194 O O   . MET   B 1 149 ? 35.25038  2.81672   6.86203   1.000 20.58178 ? 146 MET   B O   1 
ATOM   2195 C CB  . MET   B 1 149 ? 34.69689  2.68085   3.74070   1.000 19.51182 ? 146 MET   B CB  1 
ATOM   2196 C CG  . MET   B 1 149 ? 33.99452  1.40461   3.37707   1.000 19.08476 ? 146 MET   B CG  1 
ATOM   2197 S SD  . MET   B 1 149 ? 34.81329  0.59526   1.98386   1.000 22.79230 ? 146 MET   B SD  1 
ATOM   2198 C CE  . MET   B 1 149 ? 36.31457  0.02148   2.76392   1.000 25.83603 ? 146 MET   B CE  1 
ATOM   2199 N N   . SER   B 1 150 ? 33.20841  1.91289   6.55752   1.000 17.51478 ? 147 SER   B N   1 
ATOM   2200 C CA  . SER   B 1 150 ? 33.28617  1.11620   7.76928   1.000 18.43948 ? 147 SER   B CA  1 
ATOM   2201 C C   . SER   B 1 150 ? 34.09731  -0.15639  7.54265   1.000 17.60679 ? 147 SER   B C   1 
ATOM   2202 O O   . SER   B 1 150 ? 34.47455  -0.50223  6.41792   1.000 17.92601 ? 147 SER   B O   1 
ATOM   2203 C CB  . SER   B 1 150 ? 31.88042  0.73823   8.24615   1.000 16.94153 ? 147 SER   B CB  1 
ATOM   2204 O OG  . SER   B 1 150 ? 31.32707  -0.25679  7.40805   1.000 18.07351 ? 147 SER   B OG  1 
ATOM   2205 N N   . GLY   B 1 151 ? 34.35470  -0.86514  8.64673   1.000 17.65701 ? 148 GLY   B N   1 
ATOM   2206 C CA  . GLY   B 1 151 ? 34.69971  -2.27044  8.59567   1.000 18.36946 ? 148 GLY   B CA  1 
ATOM   2207 C C   . GLY   B 1 151 ? 33.43208  -3.10680  8.59611   1.000 20.09191 ? 148 GLY   B C   1 
ATOM   2208 O O   . GLY   B 1 151 ? 32.33984  -2.59519  8.33643   1.000 19.46690 ? 148 GLY   B O   1 
ATOM   2209 N N   . PRO   B 1 152 ? 33.54084  -4.40364  8.87951   1.000 17.19237 ? 149 PRO   B N   1 
ATOM   2210 C CA  . PRO   B 1 152 ? 32.33505  -5.25038  8.91731   1.000 17.26428 ? 149 PRO   B CA  1 
ATOM   2211 C C   . PRO   B 1 152 ? 31.39694  -4.81255  10.03564  1.000 18.73717 ? 149 PRO   B C   1 
ATOM   2212 O O   . PRO   B 1 152 ? 31.79650  -4.70879  11.19412  1.000 19.61875 ? 149 PRO   B O   1 
ATOM   2213 C CB  . PRO   B 1 152 ? 32.89240  -6.65618  9.16753   1.000 17.99814 ? 149 PRO   B CB  1 
ATOM   2214 C CG  . PRO   B 1 152 ? 34.36881  -6.55459  8.78434   1.000 21.52932 ? 149 PRO   B CG  1 
ATOM   2215 C CD  . PRO   B 1 152 ? 34.77073  -5.17134  9.14536   1.000 19.04891 ? 149 PRO   B CD  1 
ATOM   2216 N N   . VAL   B 1 153 ? 30.13574  -4.55072  9.68082   1.000 15.46280 ? 150 VAL   B N   1 
ATOM   2217 C CA  . VAL   B 1 153 ? 29.11649  -4.15574  10.64868  1.000 15.17138 ? 150 VAL   B CA  1 
ATOM   2218 C C   . VAL   B 1 153 ? 28.01989  -5.21232  10.63751  1.000 15.64028 ? 150 VAL   B C   1 
ATOM   2219 O O   . VAL   B 1 153 ? 27.48843  -5.55389  9.57705   1.000 16.10047 ? 150 VAL   B O   1 
ATOM   2220 C CB  . VAL   B 1 153 ? 28.55009  -2.75575  10.34335  1.000 14.57504 ? 150 VAL   B CB  1 
ATOM   2221 C CG1 . VAL   B 1 153 ? 27.34768  -2.44304  11.23634  1.000 17.74468 ? 150 VAL   B CG1 1 
ATOM   2222 C CG2 . VAL   B 1 153 ? 29.61842  -1.69944  10.55287  1.000 16.25478 ? 150 VAL   B CG2 1 
ATOM   2223 N N   . PHE   B 1 154 ? 27.70272  -5.74726  11.81464  1.000 19.41109 ? 151 PHE   B N   1 
ATOM   2224 C CA  . PHE   B 1 154 ? 26.79236  -6.87616  11.95016  1.000 15.97919 ? 151 PHE   B CA  1 
ATOM   2225 C C   . PHE   B 1 154 ? 25.41138  -6.37469  12.34609  1.000 16.64250 ? 151 PHE   B C   1 
ATOM   2226 O O   . PHE   B 1 154 ? 25.27925  -5.61215  13.30826  1.000 18.13225 ? 151 PHE   B O   1 
ATOM   2227 C CB  . PHE   B 1 154 ? 27.30101  -7.86729  13.00544  1.000 16.68282 ? 151 PHE   B CB  1 
ATOM   2228 C CG  . PHE   B 1 154 ? 28.56322  -8.58864  12.61718  1.000 22.19768 ? 151 PHE   B CG  1 
ATOM   2229 C CD1 . PHE   B 1 154 ? 29.79599  -7.98567  12.76834  1.000 25.44423 ? 151 PHE   B CD1 1 
ATOM   2230 C CD2 . PHE   B 1 154 ? 28.50725  -9.88668  12.13762  1.000 23.89249 ? 151 PHE   B CD2 1 
ATOM   2231 C CE1 . PHE   B 1 154 ? 30.95677  -8.65424  12.41746  1.000 24.95035 ? 151 PHE   B CE1 1 
ATOM   2232 C CE2 . PHE   B 1 154 ? 29.66445  -10.56163 11.79100  1.000 26.94948 ? 151 PHE   B CE2 1 
ATOM   2233 C CZ  . PHE   B 1 154 ? 30.88538  -9.93850  11.92869  1.000 21.61819 ? 151 PHE   B CZ  1 
ATOM   2234 N N   . THR   B 1 155 ? 24.39195  -6.78901  11.59667  1.000 15.63323 ? 152 THR   B N   1 
ATOM   2235 C CA  . THR   B 1 155 ? 23.00167  -6.50918  11.95617  1.000 15.36890 ? 152 THR   B CA  1 
ATOM   2236 C C   . THR   B 1 155 ? 22.19466  -7.78682  11.82257  1.000 17.31578 ? 152 THR   B C   1 
ATOM   2237 O O   . THR   B 1 155 ? 22.68886  -8.82972  11.38631  1.000 17.37073 ? 152 THR   B O   1 
ATOM   2238 C CB  . THR   B 1 155 ? 22.34363  -5.43981  11.06764  1.000 16.22200 ? 152 THR   B CB  1 
ATOM   2239 O OG1 . THR   B 1 155 ? 22.11040  -5.99471  9.75912   1.000 17.11530 ? 152 THR   B OG1 1 
ATOM   2240 C CG2 . THR   B 1 155 ? 23.16747  -4.14676  10.99660  1.000 18.65380 ? 152 THR   B CG2 1 
ATOM   2241 N N   . ASP   B 1 156 ? 20.90662  -7.68696  12.13276  1.000 16.39588 ? 153 ASP   B N   1 
ATOM   2242 C CA  . ASP   B 1 156 ? 20.07169  -8.84719  11.90039  1.000 16.04428 ? 153 ASP   B CA  1 
ATOM   2243 C C   . ASP   B 1 156 ? 19.78241  -9.08180  10.42700  1.000 16.71308 ? 153 ASP   B C   1 
ATOM   2244 O O   . ASP   B 1 156 ? 19.21494  -10.12253 10.09554  1.000 18.24443 ? 153 ASP   B O   1 
ATOM   2245 C CB  . ASP   B 1 156 ? 18.76298  -8.72079  12.67623  1.000 19.38387 ? 153 ASP   B CB  1 
ATOM   2246 C CG  . ASP   B 1 156 ? 18.94605  -9.02602  14.14551  1.000 24.56908 ? 153 ASP   B CG  1 
ATOM   2247 O OD1 . ASP   B 1 156 ? 19.34059  -8.12215  14.89958  1.000 32.44545 ? 153 ASP   B OD1 1 
ATOM   2248 O OD2 . ASP   B 1 156 ? 18.73213  -10.19004 14.54189  1.000 40.49436 ? 153 ASP   B OD2 1 
ATOM   2249 N N   . SER   B 1 157 ? 20.17460  -8.16088  9.53909   1.000 15.70400 ? 154 SER   B N   1 
ATOM   2250 C CA  . SER   B 1 157 ? 20.02775  -8.37070  8.10525   1.000 17.27206 ? 154 SER   B CA  1 
ATOM   2251 C C   . SER   B 1 157 ? 21.20394  -9.10256  7.47959   1.000 17.90347 ? 154 SER   B C   1 
ATOM   2252 O O   . SER   B 1 157 ? 21.05330  -9.67738  6.39632   1.000 18.36786 ? 154 SER   B O   1 
ATOM   2253 C CB  . SER   B 1 157 ? 19.85061  -7.02620  7.38793   1.000 18.53539 ? 154 SER   B CB  1 
ATOM   2254 O OG  . SER   B 1 157 ? 18.57034  -6.47652  7.64523   1.000 22.35037 ? 154 SER   B OG  1 
ATOM   2255 N N   . GLY   B 1 158 ? 22.35666  -9.08326  8.12230   1.000 17.21592 ? 155 GLY   B N   1 
ATOM   2256 C CA  . GLY   B 1 158 ? 23.57286  -9.68627  7.57119   1.000 17.41242 ? 155 GLY   B CA  1 
ATOM   2257 C C   . GLY   B 1 158 ? 24.79491  -8.90325  8.02903   1.000 18.07281 ? 155 GLY   B C   1 
ATOM   2258 O O   . GLY   B 1 158 ? 24.79128  -8.29311  9.09847   1.000 19.51724 ? 155 GLY   B O   1 
ATOM   2259 N N   . ILE   B 1 159 ? 25.84483  -8.92682  7.21345   1.000 17.08657 ? 156 ILE   B N   1 
ATOM   2260 C CA  . ILE   B 1 159 ? 27.06263  -8.15857  7.47711   1.000 14.52040 ? 156 ILE   B CA  1 
ATOM   2261 C C   . ILE   B 1 159 ? 27.21492  -7.10032  6.39338   1.000 15.32907 ? 156 ILE   B C   1 
ATOM   2262 O O   . ILE   B 1 159 ? 27.05781  -7.40446  5.20262   1.000 15.68108 ? 156 ILE   B O   1 
ATOM   2263 C CB  . ILE   B 1 159 ? 28.30382  -9.06414  7.53192   1.000 15.91493 ? 156 ILE   B CB  1 
ATOM   2264 C CG1 . ILE   B 1 159 ? 28.04104  -10.26631 8.43579   1.000 18.63823 ? 156 ILE   B CG1 1 
ATOM   2265 C CG2 . ILE   B 1 159 ? 29.49063  -8.28807  8.05003   1.000 18.93902 ? 156 ILE   B CG2 1 
ATOM   2266 C CD1 . ILE   B 1 159 ? 29.16307  -11.28632 8.39268   1.000 18.51629 ? 156 ILE   B CD1 1 
ATOM   2267 N N   . HIS   B 1 160 ? 27.52766  -5.86661  6.80565   1.000 15.44478 ? 157 HIS   B N   1 
ATOM   2268 C CA  . HIS   B 1 160 ? 27.55107  -4.71064  5.91661   1.000 13.80896 ? 157 HIS   B CA  1 
ATOM   2269 C C   . HIS   B 1 160 ? 28.93759  -4.08966  5.82875   1.000 16.08305 ? 157 HIS   B C   1 
ATOM   2270 O O   . HIS   B 1 160 ? 29.69033  -4.05860  6.81204   1.000 17.23710 ? 157 HIS   B O   1 
ATOM   2271 C CB  . HIS   B 1 160 ? 26.61604  -3.58178  6.38944   1.000 16.43958 ? 157 HIS   B CB  1 
ATOM   2272 C CG  . HIS   B 1 160 ? 25.22062  -4.01480  6.70174   1.000 16.80100 ? 157 HIS   B CG  1 
ATOM   2273 N ND1 . HIS   B 1 160 ? 24.15144  -3.69062  5.89411   1.000 13.89023 ? 157 HIS   B ND1 1 
ATOM   2274 C CD2 . HIS   B 1 160 ? 24.70777  -4.70295  7.75092   1.000 16.52870 ? 157 HIS   B CD2 1 
ATOM   2275 C CE1 . HIS   B 1 160 ? 23.04077  -4.17967  6.42154   1.000 15.68523 ? 157 HIS   B CE1 1 
ATOM   2276 N NE2 . HIS   B 1 160 ? 23.35088  -4.79494  7.54874   1.000 16.47340 ? 157 HIS   B NE2 1 
ATOM   2277 N N   . ILE   B 1 161 ? 29.24232  -3.56051  4.64283   1.000 15.25614 ? 158 ILE   B N   1 
ATOM   2278 C CA  . ILE   B 1 161 ? 30.25462  -2.52340  4.44017   1.000 15.26495 ? 158 ILE   B CA  1 
ATOM   2279 C C   . ILE   B 1 161 ? 29.49389  -1.23379  4.15923   1.000 13.79100 ? 158 ILE   B C   1 
ATOM   2280 O O   . ILE   B 1 161 ? 28.67353  -1.19683  3.23541   1.000 17.00919 ? 158 ILE   B O   1 
ATOM   2281 C CB  . ILE   B 1 161 ? 31.18712  -2.85563  3.26329   1.000 14.49180 ? 158 ILE   B CB  1 
ATOM   2282 C CG1 . ILE   B 1 161 ? 31.91291  -4.17973  3.50510   1.000 19.38303 ? 158 ILE   B CG1 1 
ATOM   2283 C CG2 . ILE   B 1 161 ? 32.19695  -1.73154  3.06150   1.000 18.80790 ? 158 ILE   B CG2 1 
ATOM   2284 C CD1 . ILE   B 1 161 ? 32.48739  -4.78176  2.21545   1.000 20.20881 ? 158 ILE   B CD1 1 
ATOM   2285 N N   . ILE   B 1 162 ? 29.74435  -0.18901  4.95257   1.000 14.08423 ? 159 ILE   B N   1 
ATOM   2286 C CA  . ILE   B 1 162 ? 29.00391  1.07000   4.87592   1.000 14.45417 ? 159 ILE   B CA  1 
ATOM   2287 C C   . ILE   B 1 162 ? 29.92476  2.16256   4.35726   1.000 17.78791 ? 159 ILE   B C   1 
ATOM   2288 O O   . ILE   B 1 162 ? 31.04550  2.32311   4.85042   1.000 16.81314 ? 159 ILE   B O   1 
ATOM   2289 C CB  . ILE   B 1 162 ? 28.42979  1.47378   6.24327   1.000 14.37608 ? 159 ILE   B CB  1 
ATOM   2290 C CG1 . ILE   B 1 162 ? 27.65186  0.30617   6.84902   1.000 13.72441 ? 159 ILE   B CG1 1 
ATOM   2291 C CG2 . ILE   B 1 162 ? 27.55333  2.70183   6.09818   1.000 15.80635 ? 159 ILE   B CG2 1 
ATOM   2292 C CD1 . ILE   B 1 162 ? 27.15091  0.60251   8.25583   1.000 18.21768 ? 159 ILE   B CD1 1 
ATOM   2293 N N   . LEU   B 1 163 ? 29.43643  2.94177   3.39324   1.000 14.21360 ? 160 LEU   B N   1 
ATOM   2294 C CA  . LEU   B 1 163 ? 30.13987  4.11518   2.89272   1.000 15.30503 ? 160 LEU   B CA  1 
ATOM   2295 C C   . LEU   B 1 163 ? 29.25423  5.32947   3.14168   1.000 17.81645 ? 160 LEU   B C   1 
ATOM   2296 O O   . LEU   B 1 163 ? 28.15164  5.41165   2.59214   1.000 17.52405 ? 160 LEU   B O   1 
ATOM   2297 C CB  . LEU   B 1 163 ? 30.45242  3.95728   1.40298   1.000 16.92960 ? 160 LEU   B CB  1 
ATOM   2298 C CG  . LEU   B 1 163 ? 31.11942  5.16563   0.74471   1.000 18.74289 ? 160 LEU   B CG  1 
ATOM   2299 C CD1 . LEU   B 1 163 ? 32.56076  5.29208   1.19844   1.000 20.75503 ? 160 LEU   B CD1 1 
ATOM   2300 C CD2 . LEU   B 1 163 ? 31.00670  5.10863   -0.77406  1.000 21.19346 ? 160 LEU   B CD2 1 
ATOM   2301 N N   . ARG   B 1 164 ? 29.70698  6.25458   3.98395   1.000 15.45753 ? 161 ARG   B N   1 
ATOM   2302 C CA  . ARG   B 1 164 ? 28.92948  7.47061   4.20886   1.000 14.81269 ? 161 ARG   B CA  1 
ATOM   2303 C C   . ARG   B 1 164 ? 29.17660  8.46154   3.07935   1.000 17.16905 ? 161 ARG   B C   1 
ATOM   2304 O O   . ARG   B 1 164 ? 30.32521  8.79964   2.78506   1.000 18.60040 ? 161 ARG   B O   1 
ATOM   2305 C CB  . ARG   B 1 164 ? 29.26998  8.11950   5.55052   1.000 18.15262 ? 161 ARG   B CB  1 
ATOM   2306 C CG  . ARG   B 1 164 ? 28.47460  9.39503   5.78052   1.000 17.20030 ? 161 ARG   B CG  1 
ATOM   2307 C CD  . ARG   B 1 164 ? 28.70290  10.05522  7.13249   1.000 19.43805 ? 161 ARG   B CD  1 
ATOM   2308 N NE  . ARG   B 1 164 ? 28.03401  11.35321  7.16330   1.000 20.03465 ? 161 ARG   B NE  1 
ATOM   2309 C CZ  . ARG   B 1 164 ? 28.31193  12.33090  8.01692   1.000 23.71598 ? 161 ARG   B CZ  1 
ATOM   2310 N NH1 . ARG   B 1 164 ? 29.19752  12.17195  8.98746   1.000 21.04103 ? 161 ARG   B NH1 1 
ATOM   2311 N NH2 . ARG   B 1 164 ? 27.68477  13.49984  7.89344   1.000 22.76180 ? 161 ARG   B NH2 1 
ATOM   2312 N N   . THR   B 1 165 ? 28.09766  8.92178   2.43834   1.000 15.14979 ? 162 THR   B N   1 
ATOM   2313 C CA  . THR   B 1 165 ? 28.23790  9.81448   1.29418   1.000 16.25184 ? 162 THR   B CA  1 
ATOM   2314 C C   . THR   B 1 165 ? 27.74241  11.23602  1.53666   1.000 19.05756 ? 162 THR   B C   1 
ATOM   2315 O O   . THR   B 1 165 ? 28.11142  12.13177  0.77112   1.000 20.47490 ? 162 THR   B O   1 
ATOM   2316 C CB  . THR   B 1 165 ? 27.50751  9.23114   0.08279   1.000 18.05795 ? 162 THR   B CB  1 
ATOM   2317 O OG1 . THR   B 1 165 ? 26.10584  9.14792   0.37176   1.000 19.59780 ? 162 THR   B OG1 1 
ATOM   2318 C CG2 . THR   B 1 165 ? 28.04917  7.83142   -0.23697  1.000 17.88469 ? 162 THR   B CG2 1 
ATOM   2319 N N   A GLU   B 1 166 ? 26.92621  11.46325  2.56407   0.490 17.48264 ? 163 GLU   B N   1 
ATOM   2320 N N   B GLU   B 1 166 ? 26.89753  11.45652  2.54269   0.510 17.47605 ? 163 GLU   B N   1 
ATOM   2321 C CA  A GLU   B 1 166 ? 26.56038  12.81621  2.98666   0.490 16.08837 ? 163 GLU   B CA  1 
ATOM   2322 C CA  B GLU   B 1 166 ? 26.50875  12.80428  2.96426   0.510 16.09214 ? 163 GLU   B CA  1 
ATOM   2323 C C   A GLU   B 1 166 ? 26.54922  12.89244  4.51230   0.490 16.59116 ? 163 GLU   B C   1 
ATOM   2324 C C   B GLU   B 1 166 ? 26.45376  12.85015  4.48909   0.510 16.62442 ? 163 GLU   B C   1 
ATOM   2325 O O   A GLU   B 1 166 ? 26.70766  13.96296  5.09376   0.490 11.38046 ? 163 GLU   B O   1 
ATOM   2326 O O   B GLU   B 1 166 ? 26.26897  11.81643  5.13545   0.510 12.05987 ? 163 GLU   B O   1 
ATOM   2327 C CB  A GLU   B 1 166 ? 25.19369  13.22847  2.42888   0.490 17.93050 ? 163 GLU   B CB  1 
ATOM   2328 C CB  B GLU   B 1 166 ? 25.15325  13.21619  2.37364   0.510 17.95700 ? 163 GLU   B CB  1 
ATOM   2329 C CG  A GLU   B 1 166 ? 25.12709  13.29943  0.91168   0.490 17.56354 ? 163 GLU   B CG  1 
ATOM   2330 C CG  B GLU   B 1 166 ? 25.11497  13.29337  0.85315   0.510 17.59283 ? 163 GLU   B CG  1 
ATOM   2331 C CD  A GLU   B 1 166 ? 23.73455  13.60584  0.38686   0.490 19.96755 ? 163 GLU   B CD  1 
ATOM   2332 C CD  B GLU   B 1 166 ? 23.71762  13.53822  0.29308   0.510 19.99327 ? 163 GLU   B CD  1 
ATOM   2333 O OE1 A GLU   B 1 166 ? 22.82134  13.85077  1.20840   0.490 22.57597 ? 163 GLU   B OE1 1 
ATOM   2334 O OE1 B GLU   B 1 166 ? 22.75846  13.67885  1.08711   0.510 22.45300 ? 163 GLU   B OE1 1 
ATOM   2335 O OE2 A GLU   B 1 166 ? 23.54737  13.58910  -0.85099  0.490 18.10571 ? 163 GLU   B OE2 1 
ATOM   2336 O OE2 B GLU   B 1 166 ? 23.57066  13.57231  -0.94978  0.510 18.03331 ? 163 GLU   B OE2 1 
HETATM 2337 C C   . ACE   C 2 1   ? 5.01994   18.00870  21.92453  1.000 20.07832 ? 1   ACE   C C   1 
HETATM 2338 O O   . ACE   C 2 1   ? 5.23283   16.99269  21.34917  1.000 19.30204 ? 1   ACE   C O   1 
HETATM 2339 C CH3 . ACE   C 2 1   ? 4.75504   18.02241  23.41349  1.000 18.62092 ? 1   ACE   C CH3 1 
ATOM   2340 N N   . PHE   C 2 2   ? 4.93825   19.25218  21.22228  1.000 16.40003 ? 2   PHE   C N   1 
ATOM   2341 C CA  . PHE   C 2 2   ? 5.09307   19.25168  19.79245  1.000 14.70458 ? 2   PHE   C CA  1 
ATOM   2342 C C   . PHE   C 2 2   ? 6.54897   19.17913  19.36955  1.000 16.36234 ? 2   PHE   C C   1 
ATOM   2343 O O   . PHE   C 2 2   ? 7.43990   19.67096  19.98320  1.000 17.94294 ? 2   PHE   C O   1 
ATOM   2344 C CB  . PHE   C 2 2   ? 4.45302   20.52734  19.24800  1.000 14.94936 ? 2   PHE   C CB  1 
ATOM   2345 C CG  . PHE   C 2 2   ? 2.91848   20.53337  19.25617  1.000 13.43738 ? 2   PHE   C CG  1 
ATOM   2346 C CD1 . PHE   C 2 2   ? 2.20346   20.44364  18.06933  1.000 14.42529 ? 2   PHE   C CD1 1 
ATOM   2347 C CD2 . PHE   C 2 2   ? 2.23886   20.67797  20.46704  1.000 15.20437 ? 2   PHE   C CD2 1 
ATOM   2348 C CE1 . PHE   C 2 2   ? 0.80819   20.46002  18.08263  1.000 15.20275 ? 2   PHE   C CE1 1 
ATOM   2349 C CE2 . PHE   C 2 2   ? 0.84791   20.69826  20.47741  1.000 14.85026 ? 2   PHE   C CE2 1 
ATOM   2350 C CZ  . PHE   C 2 2   ? 0.13597   20.58698  19.29312  1.000 15.36568 ? 2   PHE   C CZ  1 
HETATM 2351 C C   . YCP   C 2 3   ? 8.28882   19.05034  16.33389  1.000 14.47088 ? 3   YCP   C C   1 
HETATM 2352 N N   . YCP   C 2 3   ? 6.81858   18.44713  18.17057  1.000 13.54879 ? 3   YCP   C N   1 
HETATM 2353 O O   . YCP   C 2 3   ? 8.26053   18.56415  15.25286  1.000 16.41272 ? 3   YCP   C O   1 
HETATM 2354 C CA  . YCP   C 2 3   ? 8.19126   18.25410  17.62868  1.000 12.09334 ? 3   YCP   C CA  1 
HETATM 2355 C CB  . YCP   C 2 3   ? 8.48325   16.76430  17.44915  1.000 14.24629 ? 3   YCP   C CB  1 
HETATM 2356 C CD  . YCP   C 2 3   ? 6.04199   16.26679  17.31372  1.000 13.02863 ? 3   YCP   C CD  1 
HETATM 2357 C CE  . YCP   C 2 3   ? 5.77323   17.76557  17.35218  1.000 14.20070 ? 3   YCP   C CE  1 
HETATM 2358 C CG  . YCP   C 2 3   ? 7.39956   15.99818  16.78141  1.000 15.14353 ? 3   YCP   C CG  1 
HETATM 2359 N N   . A1A2Y C 2 4   ? 8.40984   20.47715  16.46727  1.000 15.85795 ? 4   A1A2Y C N   1 
HETATM 2360 C CA  . A1A2Y C 2 4   ? 8.44901   21.32583  15.29699  1.000 14.54751 ? 4   A1A2Y C CA  1 
HETATM 2361 C C   . A1A2Y C 2 4   ? 9.68902   21.10573  14.44141  1.000 16.50438 ? 4   A1A2Y C C   1 
HETATM 2362 C CB  . A1A2Y C 2 4   ? 8.40048   22.78254  15.78326  1.000 17.09037 ? 4   A1A2Y C CB  1 
HETATM 2363 C CG  . A1A2Y C 2 4   ? 7.20245   23.08540  16.69151  1.000 15.43074 ? 4   A1A2Y C CG  1 
HETATM 2364 C CD1 . A1A2Y C 2 4   ? 7.25830   23.43604  18.04403  1.000 15.80864 ? 4   A1A2Y C CD1 1 
HETATM 2365 C CE2 . A1A2Y C 2 4   ? 5.13001   23.41974  17.44753  1.000 15.23743 ? 4   A1A2Y C CE2 1 
HETATM 2366 C CD2 . A1A2Y C 2 4   ? 5.83554   23.08365  16.32317  1.000 15.76371 ? 4   A1A2Y C CD2 1 
HETATM 2367 C CE3 . A1A2Y C 2 4   ? 5.13651   22.83171  15.11943  1.000 18.50764 ? 4   A1A2Y C CE3 1 
HETATM 2368 C CZ3 . A1A2Y C 2 4   ? 3.74836   22.91233  15.06319  1.000 19.60169 ? 4   A1A2Y C CZ3 1 
HETATM 2369 O O23 . A1A2Y C 2 4   ? 3.10203   22.63670  13.85557  1.000 21.15976 ? 4   A1A2Y C O23 1 
HETATM 2370 C C24 . A1A2Y C 2 4   ? 1.70030   22.65373  13.87645  1.000 23.91998 ? 4   A1A2Y C C24 1 
HETATM 2371 C CZ2 . A1A2Y C 2 4   ? 3.71289   23.49705  17.38934  1.000 15.88569 ? 4   A1A2Y C CZ2 1 
HETATM 2372 N NE1 . A1A2Y C 2 4   ? 6.01292   23.62829  18.46137  1.000 15.60216 ? 4   A1A2Y C NE1 1 
HETATM 2373 C CH2 . A1A2Y C 2 4   ? 3.01926   23.24521  16.21138  1.000 19.50726 ? 4   A1A2Y C CH2 1 
HETATM 2374 O O   . A1A2Y C 2 4   ? 9.61667   21.24444  13.25203  1.000 20.19690 ? 4   A1A2Y C O   1 
HETATM 2375 N N   . NH2   C 2 5   ? 10.91151  20.75750  15.10577  1.000 17.32488 ? 5   NH2   C N   1 
HETATM 2376 C C   . ACE   D 2 1   ? 18.91680  -4.03124  2.68933   1.000 25.97019 ? 1   ACE   D C   1 
HETATM 2377 O O   . ACE   D 2 1   ? 19.74812  -3.93381  3.53090   1.000 24.58895 ? 1   ACE   D O   1 
HETATM 2378 C CH3 . ACE   D 2 1   ? 19.08012  -4.86259  1.45102   1.000 22.47400 ? 1   ACE   D CH3 1 
ATOM   2379 N N   . PHE   D 2 2   ? 17.68959  -3.30048  2.70082   1.000 22.73617 ? 2   PHE   D N   1 
ATOM   2380 C CA  . PHE   D 2 2   ? 17.38681  -2.40174  3.76578   1.000 21.62728 ? 2   PHE   D CA  1 
ATOM   2381 C C   . PHE   D 2 2   ? 17.47709  -3.12478  5.09385   1.000 17.90874 ? 2   PHE   D C   1 
ATOM   2382 O O   . PHE   D 2 2   ? 17.02221  -4.20640  5.27483   1.000 20.29440 ? 2   PHE   D O   1 
ATOM   2383 C CB  . PHE   D 2 2   ? 15.96779  -1.93104  3.49294   1.000 26.36162 ? 2   PHE   D CB  1 
ATOM   2384 C CG  . PHE   D 2 2   ? 15.63704  -0.59450  4.14449   1.000 24.88589 ? 2   PHE   D CG  1 
ATOM   2385 C CD1 . PHE   D 2 2   ? 14.97049  -0.58347  5.35766   1.000 28.99004 ? 2   PHE   D CD1 1 
ATOM   2386 C CD2 . PHE   D 2 2   ? 16.00487  0.59125   3.52772   1.000 29.46763 ? 2   PHE   D CD2 1 
ATOM   2387 C CE1 . PHE   D 2 2   ? 14.64872  0.62018   5.96783   1.000 25.11327 ? 2   PHE   D CE1 1 
ATOM   2388 C CE2 . PHE   D 2 2   ? 15.68650  1.79521   4.13746   1.000 28.17430 ? 2   PHE   D CE2 1 
ATOM   2389 C CZ  . PHE   D 2 2   ? 15.01063  1.80696   5.35114   1.000 34.06090 ? 2   PHE   D CZ  1 
HETATM 2390 C C   . YCP   D 2 3   ? 17.48001  -2.24353  8.48310   1.000 17.91556 ? 3   YCP   D C   1 
HETATM 2391 N N   . YCP   D 2 3   ? 18.14399  -2.43573  6.15610   1.000 16.92800 ? 3   YCP   D N   1 
HETATM 2392 O O   . YCP   D 2 3   ? 17.95498  -1.56418  9.31483   1.000 18.76538 ? 3   YCP   D O   1 
HETATM 2393 C CA  . YCP   D 2 3   ? 18.31017  -3.04622  7.49928   1.000 14.81667 ? 3   YCP   D CA  1 
HETATM 2394 C CB  . YCP   D 2 3   ? 19.76491  -3.12523  7.92466   1.000 13.65704 ? 3   YCP   D CB  1 
HETATM 2395 C CD  . YCP   D 2 3   ? 20.25845  -1.13062  6.46726   1.000 18.34434 ? 3   YCP   D CD  1 
HETATM 2396 C CE  . YCP   D 2 3   ? 18.78863  -1.08558  6.04424   1.000 17.17376 ? 3   YCP   D CE  1 
HETATM 2397 C CG  . YCP   D 2 3   ? 20.53039  -1.87398  7.72127   1.000 18.38443 ? 3   YCP   D CG  1 
HETATM 2398 N N   . A1A2Y D 2 4   ? 16.05135  -2.34894  8.37505   1.000 19.53186 ? 4   A1A2Y D N   1 
HETATM 2399 C CA  . A1A2Y D 2 4   ? 15.22467  -1.59989  9.29823   1.000 17.40622 ? 4   A1A2Y D CA  1 
HETATM 2400 C C   . A1A2Y D 2 4   ? 15.44336  -2.12381  10.71691  1.000 23.61056 ? 4   A1A2Y D C   1 
HETATM 2401 C CB  . A1A2Y D 2 4   ? 13.78605  -1.82410  8.85454   1.000 21.53031 ? 4   A1A2Y D CB  1 
HETATM 2402 C CG  . A1A2Y D 2 4   ? 12.73866  -1.37634  9.87019   1.000 19.55135 ? 4   A1A2Y D CG  1 
HETATM 2403 C CD1 . A1A2Y D 2 4   ? 12.36057  -0.05296  10.06553  1.000 25.15791 ? 4   A1A2Y D CD1 1 
HETATM 2404 C CE2 . A1A2Y D 2 4   ? 11.18612  -1.31149  11.45062  1.000 26.00923 ? 4   A1A2Y D CE2 1 
HETATM 2405 C CD2 . A1A2Y D 2 4   ? 11.98724  -2.18782  10.76236  1.000 23.32859 ? 4   A1A2Y D CD2 1 
HETATM 2406 C CE3 . A1A2Y D 2 4   ? 11.90257  -3.58110  11.04946  1.000 26.17638 ? 4   A1A2Y D CE3 1 
HETATM 2407 C CZ3 . A1A2Y D 2 4   ? 11.01604  -4.04462  12.02733  1.000 25.58570 ? 4   A1A2Y D CZ3 1 
HETATM 2408 O O23 . A1A2Y D 2 4   ? 10.90999  -5.40785  12.33861  1.000 26.58699 ? 4   A1A2Y D O23 1 
HETATM 2409 C C24 . A1A2Y D 2 4   ? 11.91170  -6.22523  11.79882  1.000 26.72620 ? 4   A1A2Y D C24 1 
HETATM 2410 C CZ2 . A1A2Y D 2 4   ? 10.28615  -1.78803  12.44129  1.000 20.61362 ? 4   A1A2Y D CZ2 1 
HETATM 2411 N NE1 . A1A2Y D 2 4   ? 11.43443  -0.03695  11.01859  1.000 21.15618 ? 4   A1A2Y D NE1 1 
HETATM 2412 C CH2 . A1A2Y D 2 4   ? 10.20797  -3.14394  12.72455  1.000 23.81272 ? 4   A1A2Y D CH2 1 
HETATM 2413 O O   . A1A2Y D 2 4   ? 15.58284  -3.28992  10.92121  1.000 27.49928 ? 4   A1A2Y D O   1 
HETATM 2414 N N   . NH2   D 2 5   ? 15.50016  -1.19074  11.82893  1.000 19.70252 ? 5   NH2   D N   1 
HETATM 2415 O O22 . P33   E 3 .   ? 10.73462  -6.86798  15.86905  1.000 38.43920 ? 201 P33   A O22 1 
HETATM 2416 C C21 . P33   E 3 .   ? 10.39639  -7.65183  14.75207  1.000 35.41531 ? 201 P33   A C21 1 
HETATM 2417 C C20 . P33   E 3 .   ? 9.52820   -8.76738  15.35503  1.000 35.53003 ? 201 P33   A C20 1 
HETATM 2418 O O19 . P33   E 3 .   ? 8.19696   -8.39461  15.12526  1.000 32.51813 ? 201 P33   A O19 1 
HETATM 2419 C C18 . P33   E 3 .   ? 7.35638   -9.51914  14.86516  1.000 31.38744 ? 201 P33   A C18 1 
HETATM 2420 C C17 . P33   E 3 .   ? 5.88890   -8.99112  14.83708  1.000 28.01038 ? 201 P33   A C17 1 
HETATM 2421 O O16 . P33   E 3 .   ? 5.53145   -8.60120  16.15232  1.000 30.31236 ? 201 P33   A O16 1 
HETATM 2422 C C15 . P33   E 3 .   ? 4.19690   -8.14995  16.30710  1.000 25.39934 ? 201 P33   A C15 1 
HETATM 2423 C C14 . P33   E 3 .   ? 4.13302   -7.37747  17.65933  1.000 36.39332 ? 201 P33   A C14 1 
HETATM 2424 O O13 . P33   E 3 .   ? 5.22957   -6.46008  17.67230  1.000 46.88352 ? 201 P33   A O13 1 
HETATM 2425 C C12 . P33   E 3 .   ? 5.14889   -5.37492  18.60181  1.000 37.29778 ? 201 P33   A C12 1 
HETATM 2426 C C11 . P33   E 3 .   ? 4.52278   -4.10328  17.92925  1.000 32.53128 ? 201 P33   A C11 1 
HETATM 2427 O O10 . P33   E 3 .   ? 5.55677   -3.18505  17.53163  1.000 44.83467 ? 201 P33   A O10 1 
HETATM 2428 C C9  . P33   E 3 .   ? 5.14690   -1.85588  17.11849  1.000 26.97052 ? 201 P33   A C9  1 
HETATM 2429 C C8  . P33   E 3 .   ? 3.78918   -1.83686  16.33724  1.000 17.95754 ? 201 P33   A C8  1 
HETATM 2430 O O7  . P33   E 3 .   ? 3.27974   -0.48776  16.23068  1.000 43.27509 ? 201 P33   A O7  1 
HETATM 2431 C C6  . P33   E 3 .   ? 2.04258   -0.21189  16.90978  1.000 19.24516 ? 201 P33   A C6  1 
HETATM 2432 C C5  . P33   E 3 .   ? 0.81768   -0.48600  15.92193  1.000 24.35030 ? 201 P33   A C5  1 
HETATM 2433 O O4  . P33   E 3 .   ? -0.36596  -0.77542  16.67812  1.000 45.13836 ? 201 P33   A O4  1 
HETATM 2434 C C3  . P33   E 3 .   ? -1.32722  -1.63844  16.05722  1.000 38.36978 ? 201 P33   A C3  1 
HETATM 2435 C C2  . P33   E 3 .   ? -2.21058  -2.32471  17.15439  1.000 42.09483 ? 201 P33   A C2  1 
HETATM 2436 O O1  . P33   E 3 .   ? -2.84556  -1.28978  17.88151  1.000 46.90840 ? 201 P33   A O1  1 
HETATM 2437 S S   . SO4   F 4 .   ? 13.06895  -12.36938 14.38071  1.000 31.26270 ? 202 SO4   A S   1 
HETATM 2438 O O1  . SO4   F 4 .   ? 13.98772  -11.26627 14.61764  1.000 36.96626 ? 202 SO4   A O1  1 
HETATM 2439 O O2  . SO4   F 4 .   ? 13.27299  -13.40298 15.40170  1.000 34.53684 ? 202 SO4   A O2  1 
HETATM 2440 O O3  . SO4   F 4 .   ? 11.69537  -11.87250 14.43678  1.000 32.13503 ? 202 SO4   A O3  1 
HETATM 2441 O O4  . SO4   F 4 .   ? 13.31708  -12.92805 13.05759  1.000 26.80362 ? 202 SO4   A O4  1 
HETATM 2442 S S   . SO4   G 4 .   ? -5.27791  8.69185   3.57070   1.000 58.89879 ? 203 SO4   A S   1 
HETATM 2443 O O1  . SO4   G 4 .   ? -3.99632  9.03238   4.18131   1.000 45.14699 ? 203 SO4   A O1  1 
HETATM 2444 O O2  . SO4   G 4 .   ? -5.07779  8.57315   2.12963   1.000 46.52341 ? 203 SO4   A O2  1 
HETATM 2445 O O3  . SO4   G 4 .   ? -5.73741  7.42173   4.12657   1.000 50.71531 ? 203 SO4   A O3  1 
HETATM 2446 O O4  . SO4   G 4 .   ? -6.27299  9.73068   3.84705   1.000 35.06077 ? 203 SO4   A O4  1 
HETATM 2447 S S   . SO4   H 4 .   ? 13.17745  7.86748   36.40234  1.000 41.43846 ? 204 SO4   A S   1 
HETATM 2448 O O1  . SO4   H 4 .   ? 14.10756  7.72226   35.28784  1.000 38.89088 ? 204 SO4   A O1  1 
HETATM 2449 O O2  . SO4   H 4 .   ? 12.04978  6.95332   36.23401  1.000 44.89054 ? 204 SO4   A O2  1 
HETATM 2450 O O3  . SO4   H 4 .   ? 13.85544  7.57890   37.66057  1.000 49.78472 ? 204 SO4   A O3  1 
HETATM 2451 O O4  . SO4   H 4 .   ? 12.68336  9.23706   36.41762  1.000 39.95280 ? 204 SO4   A O4  1 
HETATM 2452 S S   . SO4   I 4 .   ? -8.62943  19.84034  6.71145   1.000 42.99110 ? 205 SO4   A S   1 
HETATM 2453 O O1  . SO4   I 4 .   ? -7.40421  19.81806  5.92348   1.000 42.55918 ? 205 SO4   A O1  1 
HETATM 2454 O O2  . SO4   I 4 .   ? -9.56981  18.90338  6.10935   1.000 42.62903 ? 205 SO4   A O2  1 
HETATM 2455 O O3  . SO4   I 4 .   ? -8.33500  19.46263  8.09008   1.000 50.23086 ? 205 SO4   A O3  1 
HETATM 2456 O O4  . SO4   I 4 .   ? -9.17737  21.19587  6.70156   1.000 49.66139 ? 205 SO4   A O4  1 
HETATM 2457 S S   . SO4   J 4 .   ? 14.13654  17.71693  10.52313  1.000 60.52527 ? 206 SO4   A S   1 
HETATM 2458 O O1  . SO4   J 4 .   ? 15.09863  18.07793  9.49045   1.000 61.32322 ? 206 SO4   A O1  1 
HETATM 2459 O O2  . SO4   J 4 .   ? 12.78635  17.96118  10.01387  1.000 26.29593 ? 206 SO4   A O2  1 
HETATM 2460 O O3  . SO4   J 4 .   ? 14.30829  16.31124  10.87358  1.000 44.83727 ? 206 SO4   A O3  1 
HETATM 2461 O O4  . SO4   J 4 .   ? 14.38234  18.52347  11.71313  1.000 54.33002 ? 206 SO4   A O4  1 
HETATM 2462 S S   . SO4   K 4 .   ? -8.60061  15.82283  26.57535  1.000 30.20578 ? 207 SO4   A S   1 
HETATM 2463 O O1  . SO4   K 4 .   ? -7.39593  15.15162  26.12338  1.000 24.65394 ? 207 SO4   A O1  1 
HETATM 2464 O O2  . SO4   K 4 .   ? -9.56446  15.85083  25.48257  1.000 33.07278 ? 207 SO4   A O2  1 
HETATM 2465 O O3  . SO4   K 4 .   ? -9.16950  15.06072  27.69467  1.000 32.14511 ? 207 SO4   A O3  1 
HETATM 2466 O O4  . SO4   K 4 .   ? -8.25712  17.16877  27.00699  1.000 38.20758 ? 207 SO4   A O4  1 
HETATM 2467 O O22 . P33   L 3 .   ? 43.64975  -3.68735  9.54511   1.000 49.01533 ? 301 P33   B O22 1 
HETATM 2468 C C21 . P33   L 3 .   ? 43.56913  -4.21790  10.84726  1.000 48.33628 ? 301 P33   B C21 1 
HETATM 2469 C C20 . P33   L 3 .   ? 44.99747  -4.05883  11.42596  1.000 40.46343 ? 301 P33   B C20 1 
HETATM 2470 O O19 . P33   L 3 .   ? 45.37311  -2.71031  11.25925  1.000 45.81301 ? 301 P33   B O19 1 
HETATM 2471 C C18 . P33   L 3 .   ? 46.50648  -2.54005  10.41610  1.000 40.07573 ? 301 P33   B C18 1 
HETATM 2472 C C17 . P33   L 3 .   ? 46.21935  -1.29962  9.54374   1.000 34.17610 ? 301 P33   B C17 1 
HETATM 2473 O O16 . P33   L 3 .   ? 45.49883  -1.70507  8.39524   1.000 46.62090 ? 301 P33   B O16 1 
HETATM 2474 C C15 . P33   L 3 .   ? 45.50971  -0.75363  7.33814   1.000 38.61881 ? 301 P33   B C15 1 
HETATM 2475 C C14 . P33   L 3 .   ? 45.27784  -1.52774  5.99924   1.000 45.23621 ? 301 P33   B C14 1 
HETATM 2476 O O13 . P33   L 3 .   ? 43.92633  -1.97780  5.95258   1.000 52.74430 ? 301 P33   B O13 1 
HETATM 2477 C C12 . P33   L 3 .   ? 43.71214  -3.36877  6.24295   1.000 49.53903 ? 301 P33   B C12 1 
HETATM 2478 C C11 . P33   L 3 .   ? 42.27970  -3.79870  5.72184   1.000 50.34972 ? 301 P33   B C11 1 
HETATM 2479 O O10 . P33   L 3 .   ? 41.47393  -4.31877  6.78938   1.000 52.24161 ? 301 P33   B O10 1 
HETATM 2480 C C9  . P33   L 3 .   ? 40.87821  -3.34995  7.65803   1.000 42.84689 ? 301 P33   B C9  1 
HETATM 2481 C C8  . P33   L 3 .   ? 39.38637  -3.11964  7.26362   1.000 37.98341 ? 301 P33   B C8  1 
HETATM 2482 O O7  . P33   L 3 .   ? 38.85086  -1.99499  7.96654   1.000 41.62822 ? 301 P33   B O7  1 
HETATM 2483 C C6  . P33   L 3 .   ? 38.14613  -1.05469  7.16962   1.000 28.78427 ? 301 P33   B C6  1 
HETATM 2484 C C5  . P33   L 3 .   ? 38.73280  0.34836   7.45269   1.000 28.31631 ? 301 P33   B C5  1 
HETATM 2485 O O4  . P33   L 3 .   ? 37.81674  1.35357   6.98494   1.000 39.26044 ? 301 P33   B O4  1 
HETATM 2486 C C3  . P33   L 3 .   ? 37.92020  1.65518   5.60853   1.000 35.40398 ? 301 P33   B C3  1 
HETATM 2487 C C2  . P33   L 3 .   ? 39.03292  2.71528   5.42362   1.000 46.89873 ? 301 P33   B C2  1 
HETATM 2488 O O1  . P33   L 3 .   ? 38.92249  3.09640   4.06817   1.000 44.25599 ? 301 P33   B O1  1 
HETATM 2489 S S   . SO4   M 4 .   ? 29.65446  -15.80164 -3.35492  1.000 47.27264 ? 302 SO4   B S   1 
HETATM 2490 O O1  . SO4   M 4 .   ? 31.08741  -15.74571 -3.64452  1.000 37.61045 ? 302 SO4   B O1  1 
HETATM 2491 O O2  . SO4   M 4 .   ? 29.24873  -14.55772 -2.70654  1.000 33.06188 ? 302 SO4   B O2  1 
HETATM 2492 O O3  . SO4   M 4 .   ? 28.92580  -15.95026 -4.60771  1.000 42.57928 ? 302 SO4   B O3  1 
HETATM 2493 O O4  . SO4   M 4 .   ? 29.34613  -16.94720 -2.49444  1.000 47.60029 ? 302 SO4   B O4  1 
HETATM 2494 S S   . SO4   N 4 .   ? 15.43884  -5.77901  -0.01361  1.000 50.28887 ? 303 SO4   B S   1 
HETATM 2495 O O1  . SO4   N 4 .   ? 16.57890  -5.56450  -0.89357  1.000 39.14321 ? 303 SO4   B O1  1 
HETATM 2496 O O2  . SO4   N 4 .   ? 14.22526  -5.82516  -0.81916  1.000 54.27296 ? 303 SO4   B O2  1 
HETATM 2497 O O3  . SO4   N 4 .   ? 15.63947  -7.04910  0.68674   1.000 44.92452 ? 303 SO4   B O3  1 
HETATM 2498 O O4  . SO4   N 4 .   ? 15.34812  -4.68077  0.94607   1.000 42.51573 ? 303 SO4   B O4  1 
HETATM 2499 S S   . SO4   O 4 .   ? 31.96004  15.29933  8.18255   1.000 61.78480 ? 304 SO4   B S   1 
HETATM 2500 O O1  . SO4   O 4 .   ? 33.26662  15.94899  8.13849   1.000 55.83492 ? 304 SO4   B O1  1 
HETATM 2501 O O2  . SO4   O 4 .   ? 31.32704  15.36155  6.87089   1.000 53.77517 ? 304 SO4   B O2  1 
HETATM 2502 O O3  . SO4   O 4 .   ? 32.13876  13.90432  8.55362   1.000 47.72522 ? 304 SO4   B O3  1 
HETATM 2503 O O4  . SO4   O 4 .   ? 31.10391  15.96228  9.16279   1.000 60.85575 ? 304 SO4   B O4  1 
HETATM 2504 O O   . HOH   P 5 .   ? -8.64007  17.09064  11.45798  1.000 34.29472 ? 301 HOH   A O   1 
HETATM 2505 O O   . HOH   P 5 .   ? -6.86579  6.74336   6.06661   1.000 27.61359 ? 302 HOH   A O   1 
HETATM 2506 O O   . HOH   P 5 .   ? -7.59183  8.62195   20.66560  1.000 34.04305 ? 303 HOH   A O   1 
HETATM 2507 O O   . HOH   P 5 .   ? 0.528     -5.144    34.435    1.000 35.43554 ? 304 HOH   A O   1 
HETATM 2508 O O   . HOH   P 5 .   ? 15.70597  16.38542  7.79872   1.000 46.51292 ? 305 HOH   A O   1 
HETATM 2509 O O   . HOH   P 5 .   ? -7.91850  4.78642   20.57296  1.000 28.23293 ? 306 HOH   A O   1 
HETATM 2510 O O   . HOH   P 5 .   ? 1.17631   -2.66656  13.96985  1.000 38.29657 ? 307 HOH   A O   1 
HETATM 2511 O O   . HOH   P 5 .   ? 11.61619  19.02465  19.33015  1.000 32.20986 ? 308 HOH   A O   1 
HETATM 2512 O O   . HOH   P 5 .   ? 11.643    6.185     33.813    1.000 31.99948 ? 309 HOH   A O   1 
HETATM 2513 O O   . HOH   P 5 .   ? 14.11156  14.78301  14.42382  1.000 35.36438 ? 310 HOH   A O   1 
HETATM 2514 O O   . HOH   P 5 .   ? 0.63496   18.46665  3.52404   1.000 21.73150 ? 311 HOH   A O   1 
HETATM 2515 O O   . HOH   P 5 .   ? -2.936    21.545    22.732    1.000 22.20635 ? 312 HOH   A O   1 
HETATM 2516 O O   . HOH   P 5 .   ? 2.16879   1.66361   9.95333   1.000 17.41968 ? 313 HOH   A O   1 
HETATM 2517 O O   . HOH   P 5 .   ? 1.05045   13.68019  24.52769  1.000 13.88593 ? 314 HOH   A O   1 
HETATM 2518 O O   . HOH   P 5 .   ? 4.52042   -1.23053  0.45649   1.000 34.86528 ? 315 HOH   A O   1 
HETATM 2519 O O   . HOH   P 5 .   ? -1.49200  -0.97911  11.53484  1.000 21.30547 ? 316 HOH   A O   1 
HETATM 2520 O O   . HOH   P 5 .   ? 14.998    5.448     34.342    1.000 36.44932 ? 317 HOH   A O   1 
HETATM 2521 O O   . HOH   P 5 .   ? -7.10459  14.28080  7.05824   1.000 24.37914 ? 318 HOH   A O   1 
HETATM 2522 O O   . HOH   P 5 .   ? 0.80174   9.30547   2.29206   1.000 34.33989 ? 319 HOH   A O   1 
HETATM 2523 O O   . HOH   P 5 .   ? 18.41544  15.64989  32.78345  1.000 31.94111 ? 320 HOH   A O   1 
HETATM 2524 O O   . HOH   P 5 .   ? -1.31248  20.79001  15.05276  1.000 23.82443 ? 321 HOH   A O   1 
HETATM 2525 O O   . HOH   P 5 .   ? 0.98466   3.42282   4.52695   1.000 27.30152 ? 322 HOH   A O   1 
HETATM 2526 O O   . HOH   P 5 .   ? 12.38896  -11.46438 11.06816  1.000 26.69086 ? 323 HOH   A O   1 
HETATM 2527 O O   . HOH   P 5 .   ? 7.75421   -6.47533  16.89173  1.000 34.15595 ? 324 HOH   A O   1 
HETATM 2528 O O   . HOH   P 5 .   ? 7.17786   -2.16905  20.04882  1.000 30.51922 ? 325 HOH   A O   1 
HETATM 2529 O O   . HOH   P 5 .   ? 20.35336  2.70978   29.73057  1.000 29.72280 ? 326 HOH   A O   1 
HETATM 2530 O O   . HOH   P 5 .   ? 8.07684   -14.22561 16.68798  1.000 32.96727 ? 327 HOH   A O   1 
HETATM 2531 O O   . HOH   P 5 .   ? -0.50839  16.76020  27.30662  1.000 15.39034 ? 328 HOH   A O   1 
HETATM 2532 O O   . HOH   P 5 .   ? -1.70735  2.69950   34.07159  1.000 24.83779 ? 329 HOH   A O   1 
HETATM 2533 O O   . HOH   P 5 .   ? 9.22160   17.97023  7.85811   1.000 28.46758 ? 330 HOH   A O   1 
HETATM 2534 O O   . HOH   P 5 .   ? -6.23862  10.89122  21.51406  1.000 20.20337 ? 331 HOH   A O   1 
HETATM 2535 O O   . HOH   P 5 .   ? -6.00074  13.26751  17.51018  1.000 15.83602 ? 332 HOH   A O   1 
HETATM 2536 O O   . HOH   P 5 .   ? 8.02773   -2.33635  15.61431  1.000 30.00339 ? 333 HOH   A O   1 
HETATM 2537 O O   . HOH   P 5 .   ? 9.69648   -2.80440  26.87567  1.000 31.25441 ? 334 HOH   A O   1 
HETATM 2538 O O   . HOH   P 5 .   ? -0.176    -6.278    28.494    1.000 23.21632 ? 335 HOH   A O   1 
HETATM 2539 O O   . HOH   P 5 .   ? 5.392     21.791    22.592    1.000 18.40118 ? 336 HOH   A O   1 
HETATM 2540 O O   . HOH   P 5 .   ? 7.13556   9.59664   30.53263  1.000 18.86938 ? 337 HOH   A O   1 
HETATM 2541 O O   . HOH   P 5 .   ? 4.78318   18.11404  9.18505   1.000 16.01634 ? 338 HOH   A O   1 
HETATM 2542 O O   . HOH   P 5 .   ? 4.37765   12.94592  38.02261  1.000 22.89885 ? 339 HOH   A O   1 
HETATM 2543 O O   . HOH   P 5 .   ? 9.50089   8.23654   9.80960   1.000 16.03093 ? 340 HOH   A O   1 
HETATM 2544 O O   . HOH   P 5 .   ? 0.71731   -13.25645 9.91193   1.000 23.21553 ? 341 HOH   A O   1 
HETATM 2545 O O   . HOH   P 5 .   ? 0.54354   16.22899  1.96384   1.000 26.67538 ? 342 HOH   A O   1 
HETATM 2546 O O   . HOH   P 5 .   ? 11.29876  21.04465  43.24092  1.000 29.89173 ? 343 HOH   A O   1 
HETATM 2547 O O   . HOH   P 5 .   ? 12.98749  -1.71129  23.98138  1.000 32.98871 ? 344 HOH   A O   1 
HETATM 2548 O O   . HOH   P 5 .   ? 0.389     10.387    35.853    1.000 20.55355 ? 345 HOH   A O   1 
HETATM 2549 O O   . HOH   P 5 .   ? -6.84371  19.82629  18.60202  1.000 32.25513 ? 346 HOH   A O   1 
HETATM 2550 O O   . HOH   P 5 .   ? -5.91494  -0.76689  24.09265  1.000 22.26439 ? 347 HOH   A O   1 
HETATM 2551 O O   . HOH   P 5 .   ? 5.05725   3.60452   33.17908  1.000 27.99681 ? 348 HOH   A O   1 
HETATM 2552 O O   . HOH   P 5 .   ? -10.06739 10.94715  8.15213   1.000 33.45559 ? 349 HOH   A O   1 
HETATM 2553 O O   . HOH   P 5 .   ? 11.06693  9.12684   7.56199   1.000 21.86970 ? 350 HOH   A O   1 
HETATM 2554 O O   . HOH   P 5 .   ? 17.32215  10.54360  18.95068  1.000 38.06858 ? 351 HOH   A O   1 
HETATM 2555 O O   . HOH   P 5 .   ? 17.47540  15.76284  21.35033  1.000 32.63045 ? 352 HOH   A O   1 
HETATM 2556 O O   . HOH   P 5 .   ? 11.73611  4.54164   10.54367  1.000 19.04424 ? 353 HOH   A O   1 
HETATM 2557 O O   . HOH   P 5 .   ? 8.96139   11.54576  32.72986  1.000 18.73173 ? 354 HOH   A O   1 
HETATM 2558 O O   . HOH   P 5 .   ? 12.90139  1.81637   30.93464  1.000 23.10534 ? 355 HOH   A O   1 
HETATM 2559 O O   . HOH   P 5 .   ? -4.41113  -0.15263  35.01078  1.000 40.95873 ? 356 HOH   A O   1 
HETATM 2560 O O   . HOH   P 5 .   ? -3.54060  19.89566  20.50506  1.000 21.83209 ? 357 HOH   A O   1 
HETATM 2561 O O   . HOH   P 5 .   ? -1.45707  10.14157  3.75405   1.000 29.47681 ? 358 HOH   A O   1 
HETATM 2562 O O   . HOH   P 5 .   ? -6.65955  17.40320  4.81956   1.000 27.45576 ? 359 HOH   A O   1 
HETATM 2563 O O   . HOH   P 5 .   ? 4.45315   -19.10011 8.70752   1.000 25.44869 ? 360 HOH   A O   1 
HETATM 2564 O O   . HOH   P 5 .   ? -0.91052  -1.30306  33.43673  1.000 32.26812 ? 361 HOH   A O   1 
HETATM 2565 O O   . HOH   P 5 .   ? -1.11863  22.88802  12.11206  1.000 29.70251 ? 362 HOH   A O   1 
HETATM 2566 O O   . HOH   P 5 .   ? 12.64321  27.92280  25.14492  1.000 40.98376 ? 363 HOH   A O   1 
HETATM 2567 O O   . HOH   P 5 .   ? 7.97108   17.98028  3.95898   1.000 26.97304 ? 364 HOH   A O   1 
HETATM 2568 O O   . HOH   P 5 .   ? -5.35149  3.18932   33.51340  1.000 28.70365 ? 365 HOH   A O   1 
HETATM 2569 O O   . HOH   P 5 .   ? 7.64910   -20.82731 9.15884   1.000 27.27361 ? 366 HOH   A O   1 
HETATM 2570 O O   . HOH   P 5 .   ? 6.44346   -4.34710  0.16598   1.000 34.23260 ? 367 HOH   A O   1 
HETATM 2571 O O   . HOH   P 5 .   ? 0.84633   -7.13501  16.41951  1.000 25.05319 ? 368 HOH   A O   1 
HETATM 2572 O O   . HOH   P 5 .   ? 0.50327   2.34839   7.73552   1.000 16.29322 ? 369 HOH   A O   1 
HETATM 2573 O O   . HOH   P 5 .   ? -11.16791 9.89234   10.85133  1.000 29.39242 ? 370 HOH   A O   1 
HETATM 2574 O O   . HOH   P 5 .   ? 4.057     -4.179    28.714    1.000 30.15215 ? 371 HOH   A O   1 
HETATM 2575 O O   . HOH   P 5 .   ? -3.93295  -2.11457  9.48168   1.000 25.28854 ? 372 HOH   A O   1 
HETATM 2576 O O   . HOH   P 5 .   ? 6.02212   -3.72876  22.06902  1.000 23.61996 ? 373 HOH   A O   1 
HETATM 2577 O O   . HOH   P 5 .   ? 7.40577   6.94111   31.09144  1.000 21.70263 ? 374 HOH   A O   1 
HETATM 2578 O O   . HOH   P 5 .   ? 5.13344   9.49796   4.71756   1.000 16.92742 ? 375 HOH   A O   1 
HETATM 2579 O O   . HOH   P 5 .   ? 13.52182  10.31719  33.83656  1.000 19.15976 ? 376 HOH   A O   1 
HETATM 2580 O O   . HOH   P 5 .   ? 7.02002   24.40772  12.07414  1.000 30.38376 ? 377 HOH   A O   1 
HETATM 2581 O O   . HOH   P 5 .   ? 0.40829   0.95294   11.89317  1.000 17.25399 ? 378 HOH   A O   1 
HETATM 2582 O O   . HOH   P 5 .   ? 11.60039  18.70883  17.13939  1.000 35.11097 ? 379 HOH   A O   1 
HETATM 2583 O O   . HOH   P 5 .   ? 12.07422  7.08292   14.08987  1.000 16.61013 ? 380 HOH   A O   1 
HETATM 2584 O O   . HOH   P 5 .   ? -1.68777  22.38009  3.71930   1.000 25.91538 ? 381 HOH   A O   1 
HETATM 2585 O O   . HOH   P 5 .   ? -4.37979  1.30962   16.26844  1.000 22.43778 ? 382 HOH   A O   1 
HETATM 2586 O O   . HOH   P 5 .   ? -6.24248  2.01579   22.97800  1.000 20.99642 ? 383 HOH   A O   1 
HETATM 2587 O O   . HOH   P 5 .   ? -0.69683  14.01810  26.59558  1.000 14.41032 ? 384 HOH   A O   1 
HETATM 2588 O O   . HOH   P 5 .   ? -3.55628  -6.18610  19.14370  1.000 37.50374 ? 385 HOH   A O   1 
HETATM 2589 O O   . HOH   P 5 .   ? -3.77067  10.97064  34.10907  1.000 26.07800 ? 386 HOH   A O   1 
HETATM 2590 O O   . HOH   P 5 .   ? -8.33118  -4.39464  30.23139  1.000 33.79749 ? 387 HOH   A O   1 
HETATM 2591 O O   . HOH   P 5 .   ? 15.10192  10.63068  20.71870  1.000 23.69174 ? 388 HOH   A O   1 
HETATM 2592 O O   . HOH   P 5 .   ? -6.80436  2.26235   30.16974  1.000 24.72461 ? 389 HOH   A O   1 
HETATM 2593 O O   . HOH   P 5 .   ? 2.53274   -17.33144 9.52013   1.000 21.08975 ? 390 HOH   A O   1 
HETATM 2594 O O   . HOH   P 5 .   ? -0.565    23.976    23.838    1.000 25.80975 ? 391 HOH   A O   1 
HETATM 2595 O O   . HOH   P 5 .   ? 19.95402  16.31279  30.69236  1.000 37.96953 ? 392 HOH   A O   1 
HETATM 2596 O O   . HOH   P 5 .   ? 6.22627   0.45552   29.55872  1.000 19.44664 ? 393 HOH   A O   1 
HETATM 2597 O O   . HOH   P 5 .   ? -7.44153  16.77762  8.90213   1.000 34.37665 ? 394 HOH   A O   1 
HETATM 2598 O O   . HOH   P 5 .   ? 3.40105   23.78684  6.24559   1.000 37.09876 ? 395 HOH   A O   1 
HETATM 2599 O O   . HOH   P 5 .   ? 15.71672  -0.32262  24.83000  1.000 31.25549 ? 396 HOH   A O   1 
HETATM 2600 O O   . HOH   P 5 .   ? 0.96531   -10.61091 2.37683   1.000 38.17619 ? 397 HOH   A O   1 
HETATM 2601 O O   . HOH   P 5 .   ? 8.32563   18.36415  22.51207  1.000 30.45486 ? 398 HOH   A O   1 
HETATM 2602 O O   . HOH   P 5 .   ? 7.88594   8.05230   35.25686  1.000 29.84592 ? 399 HOH   A O   1 
HETATM 2603 O O   . HOH   P 5 .   ? -6.14556  21.47993  14.54521  1.000 35.28632 ? 400 HOH   A O   1 
HETATM 2604 O O   . HOH   P 5 .   ? -7.61415  6.56964   15.74575  1.000 22.42416 ? 401 HOH   A O   1 
HETATM 2605 O O   . HOH   P 5 .   ? 7.23894   -9.57213  18.45542  1.000 43.88258 ? 402 HOH   A O   1 
HETATM 2606 O O   . HOH   P 5 .   ? -5.60638  -2.77487  33.51203  1.000 35.88664 ? 403 HOH   A O   1 
HETATM 2607 O O   . HOH   P 5 .   ? -1.79428  6.79095   4.77786   1.000 24.89944 ? 404 HOH   A O   1 
HETATM 2608 O O   . HOH   P 5 .   ? 9.40285   6.67155   37.72016  1.000 33.08634 ? 405 HOH   A O   1 
HETATM 2609 O O   . HOH   P 5 .   ? -6.65767  14.11565  23.18631  1.000 21.71177 ? 406 HOH   A O   1 
HETATM 2610 O O   . HOH   P 5 .   ? 12.23780  17.80899  24.44827  1.000 25.37714 ? 407 HOH   A O   1 
HETATM 2611 O O   . HOH   P 5 .   ? -5.73611  -11.52438 6.97043   1.000 37.00510 ? 408 HOH   A O   1 
HETATM 2612 O O   . HOH   P 5 .   ? -10.58650 8.50068   25.60377  1.000 40.31334 ? 409 HOH   A O   1 
HETATM 2613 O O   . HOH   P 5 .   ? -3.86485  2.84634   1.86699   1.000 34.39090 ? 410 HOH   A O   1 
HETATM 2614 O O   . HOH   P 5 .   ? -7.13108  23.89519  12.51152  1.000 50.39326 ? 411 HOH   A O   1 
HETATM 2615 O O   . HOH   P 5 .   ? -0.835    22.926    27.685    1.000 28.60846 ? 412 HOH   A O   1 
HETATM 2616 O O   . HOH   P 5 .   ? -0.88006  -9.39659  2.19002   1.000 34.79458 ? 413 HOH   A O   1 
HETATM 2617 O O   . HOH   P 5 .   ? 12.55221  -0.86972  19.33505  1.000 26.37972 ? 414 HOH   A O   1 
HETATM 2618 O O   . HOH   P 5 .   ? 15.98084  -1.81473  27.78943  1.000 41.25631 ? 415 HOH   A O   1 
HETATM 2619 O O   . HOH   P 5 .   ? 11.697    22.966    33.836    1.000 41.04285 ? 416 HOH   A O   1 
HETATM 2620 O O   . HOH   P 5 .   ? -5.65919  8.64151   34.52195  1.000 31.21268 ? 417 HOH   A O   1 
HETATM 2621 O O   . HOH   P 5 .   ? 14.05448  20.81447  17.17502  1.000 37.85075 ? 418 HOH   A O   1 
HETATM 2622 O O   . HOH   P 5 .   ? 8.28576   6.20547   33.63732  1.000 29.77993 ? 419 HOH   A O   1 
HETATM 2623 O O   . HOH   P 5 .   ? -3.96756  1.83214   18.97839  1.000 23.82151 ? 420 HOH   A O   1 
HETATM 2624 O O   . HOH   P 5 .   ? 3.81325   -4.70976  21.25585  1.000 35.44413 ? 421 HOH   A O   1 
HETATM 2625 O O   . HOH   P 5 .   ? 1.888     23.384    28.302    1.000 32.41947 ? 422 HOH   A O   1 
HETATM 2626 O O   . HOH   P 5 .   ? 8.97312   -12.88324 3.78651   1.000 37.97658 ? 423 HOH   A O   1 
HETATM 2627 O O   . HOH   P 5 .   ? -8.37856  6.98174   18.51005  1.000 27.68205 ? 424 HOH   A O   1 
HETATM 2628 O O   . HOH   P 5 .   ? -1.69888  11.98387  35.45530  1.000 31.49308 ? 425 HOH   A O   1 
HETATM 2629 O O   . HOH   P 5 .   ? 7.54337   9.14926   3.40496   1.000 30.40782 ? 426 HOH   A O   1 
HETATM 2630 O O   . HOH   P 5 .   ? -6.89409  -4.90038  32.52627  1.000 37.94018 ? 427 HOH   A O   1 
HETATM 2631 O O   . HOH   P 5 .   ? -0.52276  5.22102   3.12487   1.000 33.34554 ? 428 HOH   A O   1 
HETATM 2632 O O   . HOH   P 5 .   ? 11.42733  -13.96776 4.82066   1.000 44.27778 ? 429 HOH   A O   1 
HETATM 2633 O O   . HOH   P 5 .   ? -8.61472  13.29402  18.60645  1.000 28.13864 ? 430 HOH   A O   1 
HETATM 2634 O O   . HOH   P 5 .   ? -2.412    23.861    25.819    1.000 35.99196 ? 431 HOH   A O   1 
HETATM 2635 O O   . HOH   P 5 .   ? -2.26938  -0.26168  -1.11735  1.000 43.00655 ? 432 HOH   A O   1 
HETATM 2636 O O   . HOH   P 5 .   ? 0.78029   1.81948   34.74332  1.000 37.18309 ? 433 HOH   A O   1 
HETATM 2637 O O   . HOH   P 5 .   ? 11.83718  -3.60932  25.27549  1.000 40.63804 ? 434 HOH   A O   1 
HETATM 2638 O O   . HOH   P 5 .   ? 5.32407   0.97521   32.19411  1.000 39.13808 ? 435 HOH   A O   1 
HETATM 2639 O O   . HOH   P 5 .   ? -5.147    22.637    24.414    1.000 35.12955 ? 436 HOH   A O   1 
HETATM 2640 O O   . HOH   P 5 .   ? 0.27792   21.17042  2.35156   1.000 29.92972 ? 437 HOH   A O   1 
HETATM 2641 O O   . HOH   P 5 .   ? 3.82805   7.72210   3.06462   1.000 27.80260 ? 438 HOH   A O   1 
HETATM 2642 O O   . HOH   P 5 .   ? 17.85334  4.06918   19.66490  1.000 33.18345 ? 439 HOH   A O   1 
HETATM 2643 O O   . HOH   P 5 .   ? -8.26886  12.71279  21.77606  1.000 37.01960 ? 440 HOH   A O   1 
HETATM 2644 O O   . HOH   P 5 .   ? 5.21954   -9.80514  20.34568  1.000 38.23781 ? 441 HOH   A O   1 
HETATM 2645 O O   . HOH   P 5 .   ? 7.42317   16.44932  1.15621   1.000 43.37956 ? 442 HOH   A O   1 
HETATM 2646 O O   . HOH   P 5 .   ? -5.99762  2.87695   20.48957  1.000 29.10791 ? 443 HOH   A O   1 
HETATM 2647 O O   . HOH   P 5 .   ? 7.36884   3.75240   34.74689  1.000 34.55146 ? 444 HOH   A O   1 
HETATM 2648 O O   . HOH   P 5 .   ? 18.22562  0.67273   23.12719  1.000 39.92465 ? 445 HOH   A O   1 
HETATM 2649 O O   . HOH   P 5 .   ? -1.88088  -7.48955  1.53868   1.000 33.85432 ? 446 HOH   A O   1 
HETATM 2650 O O   . HOH   P 5 .   ? 4.845     -19.153   6.092     1.000 31.33881 ? 447 HOH   A O   1 
HETATM 2651 O O   . HOH   P 5 .   ? 20.27297  -0.17788  27.17443  1.000 43.36642 ? 448 HOH   A O   1 
HETATM 2652 O O   . HOH   P 5 .   ? -8.69511  23.61944  18.12607  1.000 47.80941 ? 449 HOH   A O   1 
HETATM 2653 O O   . HOH   Q 5 .   ? 13.25010  -14.91636 8.18448   1.000 32.17163 ? 401 HOH   B O   1 
HETATM 2654 O O   . HOH   Q 5 .   ? 14.97382  -8.22846  13.65844  1.000 38.91444 ? 402 HOH   B O   1 
HETATM 2655 O O   . HOH   Q 5 .   ? 35.919    -1.890    -10.649   1.000 41.73747 ? 403 HOH   B O   1 
HETATM 2656 O O   . HOH   Q 5 .   ? 49.954    4.994     12.576    1.000 27.26181 ? 404 HOH   B O   1 
HETATM 2657 O O   . HOH   Q 5 .   ? 26.44872  0.29619   18.01525  1.000 36.35210 ? 405 HOH   B O   1 
HETATM 2658 O O   . HOH   Q 5 .   ? 17.18049  -8.73655  -0.37910  1.000 32.47468 ? 406 HOH   B O   1 
HETATM 2659 O O   . HOH   Q 5 .   ? 17.29790  -2.42504  -0.80960  1.000 33.31163 ? 407 HOH   B O   1 
HETATM 2660 O O   . HOH   Q 5 .   ? 35.39162  4.88886   11.19683  1.000 22.14872 ? 408 HOH   B O   1 
HETATM 2661 O O   . HOH   Q 5 .   ? 21.92245  15.09860  -2.17347  1.000 32.11082 ? 409 HOH   B O   1 
HETATM 2662 O O   . HOH   Q 5 .   ? 14.08473  8.33857   11.32777  1.000 23.15824 ? 410 HOH   B O   1 
HETATM 2663 O O   . HOH   Q 5 .   ? 38.77693  -3.38635  10.99971  1.000 35.03852 ? 411 HOH   B O   1 
HETATM 2664 O O   . HOH   Q 5 .   ? 20.28393  13.63625  0.36654   1.000 29.51152 ? 412 HOH   B O   1 
HETATM 2665 O O   . HOH   Q 5 .   ? 24.03177  -0.26126  -9.25930  1.000 34.12300 ? 413 HOH   B O   1 
HETATM 2666 O O   . HOH   Q 5 .   ? 18.54382  5.21882   11.76901  1.000 17.15621 ? 414 HOH   B O   1 
HETATM 2667 O O   . HOH   Q 5 .   ? 26.41613  -11.56826 -1.47898  1.000 21.26314 ? 415 HOH   B O   1 
HETATM 2668 O O   . HOH   Q 5 .   ? 15.08286  10.68756  14.24753  1.000 26.19549 ? 416 HOH   B O   1 
HETATM 2669 O O   . HOH   Q 5 .   ? 27.26144  4.34757   -3.70482  1.000 26.78734 ? 417 HOH   B O   1 
HETATM 2670 O O   . HOH   Q 5 .   ? 38.87263  1.14065   -4.50643  1.000 33.76768 ? 418 HOH   B O   1 
HETATM 2671 O O   . HOH   Q 5 .   ? 31.38664  -21.71096 7.91575   1.000 36.84128 ? 419 HOH   B O   1 
HETATM 2672 O O   . HOH   Q 5 .   ? 37.47487  5.21542   4.61877   1.000 31.05647 ? 420 HOH   B O   1 
HETATM 2673 O O   . HOH   Q 5 .   ? 38.48230  -13.07418 3.42509   1.000 36.74886 ? 421 HOH   B O   1 
HETATM 2674 O O   . HOH   Q 5 .   ? 28.61335  7.69108   -8.37368  1.000 28.73071 ? 422 HOH   B O   1 
HETATM 2675 O O   . HOH   Q 5 .   ? 32.40588  -12.63674 -4.45540  1.000 31.35334 ? 423 HOH   B O   1 
HETATM 2676 O O   . HOH   Q 5 .   ? 18.19358  -5.07549  10.28632  1.000 28.36302 ? 424 HOH   B O   1 
HETATM 2677 O O   . HOH   Q 5 .   ? 54.65986  -8.50164  16.74525  1.000 34.64759 ? 425 HOH   B O   1 
HETATM 2678 O O   . HOH   Q 5 .   ? 21.18360  12.97693  14.63948  1.000 37.85793 ? 426 HOH   B O   1 
HETATM 2679 O O   . HOH   Q 5 .   ? 18.63686  5.68974   18.10555  1.000 37.70886 ? 427 HOH   B O   1 
HETATM 2680 O O   . HOH   Q 5 .   ? 16.77097  -7.84296  6.23458   1.000 30.13043 ? 428 HOH   B O   1 
HETATM 2681 O O   . HOH   Q 5 .   ? 16.88394  6.38137   3.36948   1.000 33.27831 ? 429 HOH   B O   1 
HETATM 2682 O O   . HOH   Q 5 .   ? 15.12870  8.07497   8.79427   1.000 23.93764 ? 430 HOH   B O   1 
HETATM 2683 O O   . HOH   Q 5 .   ? 28.82666  14.70251  0.51014   1.000 26.85676 ? 431 HOH   B O   1 
HETATM 2684 O O   . HOH   Q 5 .   ? 29.399    5.792     -4.076    1.000 32.20844 ? 432 HOH   B O   1 
HETATM 2685 O O   . HOH   Q 5 .   ? 28.01915  0.02636   15.30510  1.000 22.22442 ? 433 HOH   B O   1 
HETATM 2686 O O   . HOH   Q 5 .   ? 21.76816  13.85070  3.69802   1.000 27.51460 ? 434 HOH   B O   1 
HETATM 2687 O O   . HOH   Q 5 .   ? 23.34694  -2.55369  -1.50058  1.000 19.72709 ? 435 HOH   B O   1 
HETATM 2688 O O   . HOH   Q 5 .   ? 17.12910  -16.91030 8.83678   1.000 28.40255 ? 436 HOH   B O   1 
HETATM 2689 O O   . HOH   Q 5 .   ? 17.89279  3.34493   -2.73813  1.000 34.29040 ? 437 HOH   B O   1 
HETATM 2690 O O   . HOH   Q 5 .   ? 27.07556  -10.68926 -9.74125  1.000 21.69085 ? 438 HOH   B O   1 
HETATM 2691 O O   . HOH   Q 5 .   ? 29.866    -17.575   -6.600    1.000 27.73066 ? 439 HOH   B O   1 
HETATM 2692 O O   . HOH   Q 5 .   ? 52.508    -11.985   9.985     1.000 25.40417 ? 440 HOH   B O   1 
HETATM 2693 O O   . HOH   Q 5 .   ? 35.07717  7.66022   11.75334  1.000 22.56959 ? 441 HOH   B O   1 
HETATM 2694 O O   . HOH   Q 5 .   ? 24.90547  7.04431   -1.00121  1.000 18.05958 ? 442 HOH   B O   1 
HETATM 2695 O O   . HOH   Q 5 .   ? 24.09871  -14.35641 -2.26077  1.000 20.82359 ? 443 HOH   B O   1 
HETATM 2696 O O   . HOH   Q 5 .   ? 34.03360  -9.40556  -9.77467  1.000 35.26323 ? 444 HOH   B O   1 
HETATM 2697 O O   . HOH   Q 5 .   ? 15.75801  -14.74179 -5.85570  1.000 29.78783 ? 445 HOH   B O   1 
HETATM 2698 O O   . HOH   Q 5 .   ? 26.05413  -5.92111  15.93789  1.000 26.54301 ? 446 HOH   B O   1 
HETATM 2699 O O   . HOH   Q 5 .   ? 23.22299  -17.14423 -7.98904  1.000 28.63867 ? 447 HOH   B O   1 
HETATM 2700 O O   . HOH   Q 5 .   ? 24.28499  14.95357  6.21395   1.000 33.87878 ? 448 HOH   B O   1 
HETATM 2701 O O   . HOH   Q 5 .   ? 17.74697  -15.52204 -7.82831  1.000 20.95785 ? 449 HOH   B O   1 
HETATM 2702 O O   . HOH   Q 5 .   ? 27.24380  6.68282   16.44871  1.000 25.94605 ? 450 HOH   B O   1 
HETATM 2703 O O   . HOH   Q 5 .   ? 33.93521  -3.70004  17.68511  1.000 35.19798 ? 451 HOH   B O   1 
HETATM 2704 O O   . HOH   Q 5 .   ? 17.00636  9.93245   0.78726   1.000 36.35049 ? 452 HOH   B O   1 
HETATM 2705 O O   . HOH   Q 5 .   ? 57.623    0.225     13.953    1.000 21.67220 ? 453 HOH   B O   1 
HETATM 2706 O O   . HOH   Q 5 .   ? 19.03768  -1.44262  0.67712   1.000 29.31431 ? 454 HOH   B O   1 
HETATM 2707 O O   . HOH   Q 5 .   ? 22.81913  -4.96252  -9.40631  1.000 32.44743 ? 455 HOH   B O   1 
HETATM 2708 O O   . HOH   Q 5 .   ? 17.87033  -1.32903  16.41382  1.000 31.02781 ? 456 HOH   B O   1 
HETATM 2709 O O   . HOH   Q 5 .   ? 24.50040  -18.37518 0.39618   1.000 24.58286 ? 457 HOH   B O   1 
HETATM 2710 O O   . HOH   Q 5 .   ? 29.40243  14.71798  11.10102  1.000 45.41913 ? 458 HOH   B O   1 
HETATM 2711 O O   . HOH   Q 5 .   ? 35.75684  2.65455   -4.10305  1.000 29.22266 ? 459 HOH   B O   1 
HETATM 2712 O O   . HOH   Q 5 .   ? 32.90289  3.26818   -5.73113  1.000 29.83921 ? 460 HOH   B O   1 
HETATM 2713 O O   . HOH   Q 5 .   ? 55.479    -10.580   9.626     1.000 28.16045 ? 461 HOH   B O   1 
HETATM 2714 O O   . HOH   Q 5 .   ? 29.75943  -18.96808 11.37247  1.000 34.24949 ? 462 HOH   B O   1 
HETATM 2715 O O   . HOH   Q 5 .   ? 17.77435  2.41994   15.70414  1.000 28.68962 ? 463 HOH   B O   1 
HETATM 2716 O O   . HOH   Q 5 .   ? 30.46511  11.91287  -0.89773  1.000 39.83234 ? 464 HOH   B O   1 
HETATM 2717 O O   . HOH   Q 5 .   ? 25.08251  -10.70327 11.08295  1.000 21.41100 ? 465 HOH   B O   1 
HETATM 2718 O O   . HOH   Q 5 .   ? 29.14255  -4.77233  14.15514  1.000 22.71680 ? 466 HOH   B O   1 
HETATM 2719 O O   . HOH   Q 5 .   ? 18.98455  11.85331  13.88995  1.000 27.41391 ? 467 HOH   B O   1 
HETATM 2720 O O   . HOH   Q 5 .   ? 39.86676  -6.84274  5.10134   1.000 35.19506 ? 468 HOH   B O   1 
HETATM 2721 O O   . HOH   Q 5 .   ? 18.21634  -9.95397  5.70395   1.000 29.30345 ? 469 HOH   B O   1 
HETATM 2722 O O   . HOH   Q 5 .   ? 47.02679  -4.09273  7.60290   1.000 44.72457 ? 470 HOH   B O   1 
HETATM 2723 O O   . HOH   Q 5 .   ? 33.29550  -17.32670 2.17795   1.000 33.06539 ? 471 HOH   B O   1 
HETATM 2724 O O   . HOH   Q 5 .   ? 35.42737  -11.59931 -1.15032  1.000 23.92681 ? 472 HOH   B O   1 
HETATM 2725 O O   . HOH   Q 5 .   ? 36.36810  4.97599   8.57867   1.000 27.99290 ? 473 HOH   B O   1 
HETATM 2726 O O   . HOH   Q 5 .   ? 50.302    7.381     14.012    1.000 29.72169 ? 474 HOH   B O   1 
HETATM 2727 O O   . HOH   Q 5 .   ? 36.97990  -9.23356  10.37186  1.000 34.60656 ? 475 HOH   B O   1 
HETATM 2728 O O   . HOH   Q 5 .   ? 25.62579  8.12515   -3.48522  1.000 22.38265 ? 476 HOH   B O   1 
HETATM 2729 O O   . HOH   Q 5 .   ? 17.69641  -8.48284  -3.31243  1.000 27.45889 ? 477 HOH   B O   1 
HETATM 2730 O O   . HOH   Q 5 .   ? 31.48897  -18.44121 1.54173   1.000 42.69105 ? 478 HOH   B O   1 
HETATM 2731 O O   . HOH   Q 5 .   ? 21.52599  -1.09948  -12.36016 1.000 34.75098 ? 479 HOH   B O   1 
HETATM 2732 O O   . HOH   Q 5 .   ? 31.06713  -3.31487  16.91025  1.000 34.42711 ? 480 HOH   B O   1 
HETATM 2733 O O   . HOH   Q 5 .   ? 33.72174  6.74175   22.12021  1.000 48.41452 ? 481 HOH   B O   1 
HETATM 2734 O O   . HOH   Q 5 .   ? 25.44477  -15.86456 -7.49985  1.000 34.91114 ? 482 HOH   B O   1 
HETATM 2735 O O   . HOH   Q 5 .   ? 41.55421  -4.06914  16.71998  1.000 48.85348 ? 483 HOH   B O   1 
HETATM 2736 O O   . HOH   Q 5 .   ? 19.41999  -3.69268  17.25275  1.000 41.29425 ? 484 HOH   B O   1 
HETATM 2737 O O   . HOH   Q 5 .   ? 32.55503  1.47334   -9.82713  1.000 37.62774 ? 485 HOH   B O   1 
HETATM 2738 O O   . HOH   Q 5 .   ? 19.505    13.411    -2.868    1.000 42.88129 ? 486 HOH   B O   1 
HETATM 2739 O O   . HOH   Q 5 .   ? 26.65988  -1.84306  -12.49394 1.000 34.60104 ? 487 HOH   B O   1 
HETATM 2740 O O   . HOH   Q 5 .   ? 29.97080  0.72539   -10.80514 1.000 36.12171 ? 488 HOH   B O   1 
HETATM 2741 O O   . HOH   Q 5 .   ? 52.664    -10.901   21.233    1.000 41.11432 ? 489 HOH   B O   1 
HETATM 2742 O O   . HOH   Q 5 .   ? 39.58174  -7.04903  -8.40791  1.000 60.46472 ? 490 HOH   B O   1 
HETATM 2743 O O   . HOH   Q 5 .   ? 24.75934  -10.86904 13.75274  1.000 31.47720 ? 491 HOH   B O   1 
HETATM 2744 O O   . HOH   Q 5 .   ? 15.88072  -7.38272  -4.80584  1.000 40.60743 ? 492 HOH   B O   1 
HETATM 2745 O O   . HOH   Q 5 .   ? 30.22155  -14.98192 -8.23622  1.000 28.20599 ? 493 HOH   B O   1 
HETATM 2746 O O   . HOH   Q 5 .   ? 27.45805  5.44916   18.89115  1.000 31.67887 ? 494 HOH   B O   1 
HETATM 2747 O O   . HOH   Q 5 .   ? 17.54628  -18.12034 11.29693  1.000 33.41346 ? 495 HOH   B O   1 
HETATM 2748 O O   . HOH   Q 5 .   ? 28.94006  9.01760   16.59010  1.000 32.13881 ? 496 HOH   B O   1 
HETATM 2749 O O   . HOH   Q 5 .   ? 11.52935  7.07666   11.40645  1.000 18.81414 ? 497 HOH   B O   1 
HETATM 2750 O O   . HOH   Q 5 .   ? 23.19477  -14.38151 13.82321  1.000 47.30614 ? 498 HOH   B O   1 
HETATM 2751 O O   . HOH   Q 5 .   ? 36.89511  -10.46749 -3.32096  1.000 36.83820 ? 499 HOH   B O   1 
HETATM 2752 O O   . HOH   Q 5 .   ? 25.26848  -2.19157  18.50233  1.000 41.03401 ? 500 HOH   B O   1 
HETATM 2753 O O   . HOH   Q 5 .   ? 34.53032  -13.23521 -3.72306  1.000 36.19300 ? 501 HOH   B O   1 
HETATM 2754 O O   . HOH   Q 5 .   ? 32.970    12.749    -0.157    1.000 36.29997 ? 502 HOH   B O   1 
HETATM 2755 O O   . HOH   Q 5 .   ? 28.63642  -2.71378  15.91384  1.000 31.26083 ? 503 HOH   B O   1 
HETATM 2756 O O   . HOH   Q 5 .   ? 14.40863  -17.52926 8.42915   1.000 33.39718 ? 504 HOH   B O   1 
HETATM 2757 O O   . HOH   Q 5 .   ? 27.15264  -10.64032 15.36141  1.000 41.56909 ? 505 HOH   B O   1 
HETATM 2758 O O   . HOH   Q 5 .   ? 16.87701  1.98818   17.75481  1.000 34.61043 ? 506 HOH   B O   1 
HETATM 2759 O O   . HOH   Q 5 .   ? 26.94008  -3.86167  17.60373  1.000 32.47933 ? 507 HOH   B O   1 
HETATM 2760 O O   . HOH   Q 5 .   ? 35.98863  -9.77472  -5.44043  1.000 36.54582 ? 508 HOH   B O   1 
HETATM 2761 O O   . HOH   Q 5 .   ? 16.95449  -0.40535  19.03997  1.000 35.87330 ? 509 HOH   B O   1 
HETATM 2762 O O   . HOH   R 5 .   ? 8.51221   21.91624  20.96335  1.000 28.90501 ? 101 HOH   C O   1 
HETATM 2763 O O   . HOH   R 5 .   ? 11.63645  20.70807  11.10812  1.000 31.38923 ? 102 HOH   C O   1 
HETATM 2764 O O   . HOH   R 5 .   ? 9.99606   21.27161  19.07913  1.000 26.88924 ? 103 HOH   C O   1 
HETATM 2765 O O   . HOH   S 5 .   ? 14.61943  -4.35993  6.49478   1.000 27.06653 ? 101 HOH   D O   1 
HETATM 2766 O O   . HOH   S 5 .   ? 15.73900  -1.45203  14.84327  1.000 28.90081 ? 102 HOH   D O   1 
HETATM 2767 O O   . HOH   S 5 .   ? 13.43835  0.54085   14.52705  1.000 39.18328 ? 103 HOH   D O   1 
HETATM 2768 O O   . HOH   S 5 .   ? 12.28953  -1.85571  15.33392  1.000 44.54046 ? 104 HOH   D O   1 
# 
