data_9VAO
# 
_entry.id   9VAO 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9VAO         pdb_00009vao 10.2210/pdb9vao/pdb 
WWPDB D_1300060062 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9VAO 
_pdbx_database_status.recvd_initial_deposition_date   2025-06-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              mukeshk@barc.gov.in 
_pdbx_contact_author.name_first         Mukesh 
_pdbx_contact_author.name_last          Kumar 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3392-7481 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Arya, R.'    1 0000-0002-0105-8410 
'Ganesh, J.'  2 0009-0001-8099-461X 
'Prashar, V.' 3 0000-0002-3327-891X 
'Kumar, M.'   4 0000-0002-3392-7481 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of Papain-like protease (PLpro) from SARS-CoV-2' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Arya, R.'    1 0000-0002-0105-8410 
primary 'Ganesh, J.'  2 0009-0001-8099-461X 
primary 'Prashar, V.' 3 0000-0002-3327-891X 
primary 'Kumar, M.'   4 0000-0002-3392-7481 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Papain-like protease nsp3' 35898.738 1   3.4.19.12,3.4.22.- ? ? ? 
2 non-polymer syn 'ZINC ION'                  65.409    1   ?                  ? ? ? 
3 non-polymer syn 'PHOSPHATE ION'             94.971    2   ?                  ? ? ? 
4 non-polymer syn GLYCEROL                    92.094    5   ?                  ? ? ? 
5 water       nat water                       18.015    313 ?                  ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SHMEVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDP
SFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNK
TVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQ
ESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SHMEVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDP
SFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNK
TVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQ
ESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'      ZN  
3 'PHOSPHATE ION' PO4 
4 GLYCEROL        GOL 
5 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   HIS n 
1 3   MET n 
1 4   GLU n 
1 5   VAL n 
1 6   ARG n 
1 7   THR n 
1 8   ILE n 
1 9   LYS n 
1 10  VAL n 
1 11  PHE n 
1 12  THR n 
1 13  THR n 
1 14  VAL n 
1 15  ASP n 
1 16  ASN n 
1 17  ILE n 
1 18  ASN n 
1 19  LEU n 
1 20  HIS n 
1 21  THR n 
1 22  GLN n 
1 23  VAL n 
1 24  VAL n 
1 25  ASP n 
1 26  MET n 
1 27  SER n 
1 28  MET n 
1 29  THR n 
1 30  TYR n 
1 31  GLY n 
1 32  GLN n 
1 33  GLN n 
1 34  PHE n 
1 35  GLY n 
1 36  PRO n 
1 37  THR n 
1 38  TYR n 
1 39  LEU n 
1 40  ASP n 
1 41  GLY n 
1 42  ALA n 
1 43  ASP n 
1 44  VAL n 
1 45  THR n 
1 46  LYS n 
1 47  ILE n 
1 48  LYS n 
1 49  PRO n 
1 50  HIS n 
1 51  ASN n 
1 52  SER n 
1 53  HIS n 
1 54  GLU n 
1 55  GLY n 
1 56  LYS n 
1 57  THR n 
1 58  PHE n 
1 59  TYR n 
1 60  VAL n 
1 61  LEU n 
1 62  PRO n 
1 63  ASN n 
1 64  ASP n 
1 65  ASP n 
1 66  THR n 
1 67  LEU n 
1 68  ARG n 
1 69  VAL n 
1 70  GLU n 
1 71  ALA n 
1 72  PHE n 
1 73  GLU n 
1 74  TYR n 
1 75  TYR n 
1 76  HIS n 
1 77  THR n 
1 78  THR n 
1 79  ASP n 
1 80  PRO n 
1 81  SER n 
1 82  PHE n 
1 83  LEU n 
1 84  GLY n 
1 85  ARG n 
1 86  TYR n 
1 87  MET n 
1 88  SER n 
1 89  ALA n 
1 90  LEU n 
1 91  ASN n 
1 92  HIS n 
1 93  THR n 
1 94  LYS n 
1 95  LYS n 
1 96  TRP n 
1 97  LYS n 
1 98  TYR n 
1 99  PRO n 
1 100 GLN n 
1 101 VAL n 
1 102 ASN n 
1 103 GLY n 
1 104 LEU n 
1 105 THR n 
1 106 SER n 
1 107 ILE n 
1 108 LYS n 
1 109 TRP n 
1 110 ALA n 
1 111 ASP n 
1 112 ASN n 
1 113 ASN n 
1 114 CYS n 
1 115 TYR n 
1 116 LEU n 
1 117 ALA n 
1 118 THR n 
1 119 ALA n 
1 120 LEU n 
1 121 LEU n 
1 122 THR n 
1 123 LEU n 
1 124 GLN n 
1 125 GLN n 
1 126 ILE n 
1 127 GLU n 
1 128 LEU n 
1 129 LYS n 
1 130 PHE n 
1 131 ASN n 
1 132 PRO n 
1 133 PRO n 
1 134 ALA n 
1 135 LEU n 
1 136 GLN n 
1 137 ASP n 
1 138 ALA n 
1 139 TYR n 
1 140 TYR n 
1 141 ARG n 
1 142 ALA n 
1 143 ARG n 
1 144 ALA n 
1 145 GLY n 
1 146 GLU n 
1 147 ALA n 
1 148 ALA n 
1 149 ASN n 
1 150 PHE n 
1 151 CYS n 
1 152 ALA n 
1 153 LEU n 
1 154 ILE n 
1 155 LEU n 
1 156 ALA n 
1 157 TYR n 
1 158 CYS n 
1 159 ASN n 
1 160 LYS n 
1 161 THR n 
1 162 VAL n 
1 163 GLY n 
1 164 GLU n 
1 165 LEU n 
1 166 GLY n 
1 167 ASP n 
1 168 VAL n 
1 169 ARG n 
1 170 GLU n 
1 171 THR n 
1 172 MET n 
1 173 SER n 
1 174 TYR n 
1 175 LEU n 
1 176 PHE n 
1 177 GLN n 
1 178 HIS n 
1 179 ALA n 
1 180 ASN n 
1 181 LEU n 
1 182 ASP n 
1 183 SER n 
1 184 CYS n 
1 185 LYS n 
1 186 ARG n 
1 187 VAL n 
1 188 LEU n 
1 189 ASN n 
1 190 VAL n 
1 191 VAL n 
1 192 CYS n 
1 193 LYS n 
1 194 THR n 
1 195 CYS n 
1 196 GLY n 
1 197 GLN n 
1 198 GLN n 
1 199 GLN n 
1 200 THR n 
1 201 THR n 
1 202 LEU n 
1 203 LYS n 
1 204 GLY n 
1 205 VAL n 
1 206 GLU n 
1 207 ALA n 
1 208 VAL n 
1 209 MET n 
1 210 TYR n 
1 211 MET n 
1 212 GLY n 
1 213 THR n 
1 214 LEU n 
1 215 SER n 
1 216 TYR n 
1 217 GLU n 
1 218 GLN n 
1 219 PHE n 
1 220 LYS n 
1 221 LYS n 
1 222 GLY n 
1 223 VAL n 
1 224 GLN n 
1 225 ILE n 
1 226 PRO n 
1 227 CYS n 
1 228 THR n 
1 229 CYS n 
1 230 GLY n 
1 231 LYS n 
1 232 GLN n 
1 233 ALA n 
1 234 THR n 
1 235 LYS n 
1 236 TYR n 
1 237 LEU n 
1 238 VAL n 
1 239 GLN n 
1 240 GLN n 
1 241 GLU n 
1 242 SER n 
1 243 PRO n 
1 244 PHE n 
1 245 VAL n 
1 246 MET n 
1 247 MET n 
1 248 SER n 
1 249 ALA n 
1 250 PRO n 
1 251 PRO n 
1 252 ALA n 
1 253 GLN n 
1 254 TYR n 
1 255 GLU n 
1 256 LEU n 
1 257 LYS n 
1 258 HIS n 
1 259 GLY n 
1 260 THR n 
1 261 PHE n 
1 262 THR n 
1 263 CYS n 
1 264 ALA n 
1 265 SER n 
1 266 GLU n 
1 267 TYR n 
1 268 THR n 
1 269 GLY n 
1 270 ASN n 
1 271 TYR n 
1 272 GLN n 
1 273 CYS n 
1 274 GLY n 
1 275 HIS n 
1 276 TYR n 
1 277 LYS n 
1 278 HIS n 
1 279 ILE n 
1 280 THR n 
1 281 SER n 
1 282 LYS n 
1 283 GLU n 
1 284 THR n 
1 285 LEU n 
1 286 TYR n 
1 287 CYS n 
1 288 ILE n 
1 289 ASP n 
1 290 GLY n 
1 291 ALA n 
1 292 LEU n 
1 293 LEU n 
1 294 THR n 
1 295 LYS n 
1 296 SER n 
1 297 SER n 
1 298 GLU n 
1 299 TYR n 
1 300 LYS n 
1 301 GLY n 
1 302 PRO n 
1 303 ILE n 
1 304 THR n 
1 305 ASP n 
1 306 VAL n 
1 307 PHE n 
1 308 TYR n 
1 309 LYS n 
1 310 GLU n 
1 311 ASN n 
1 312 SER n 
1 313 TYR n 
1 314 THR n 
1 315 THR n 
1 316 THR n 
1 317 ILE n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   317 
_entity_src_gen.gene_src_common_name               '2019-nCoV, SARS-CoV-2' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION' ?                               'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ?                               'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   -2  -2  SER SER A . n 
A 1 2   HIS 2   -1  -1  HIS HIS A . n 
A 1 3   MET 3   0   0   MET MET A . n 
A 1 4   GLU 4   1   1   GLU GLU A . n 
A 1 5   VAL 5   2   2   VAL VAL A . n 
A 1 6   ARG 6   3   3   ARG ARG A . n 
A 1 7   THR 7   4   4   THR THR A . n 
A 1 8   ILE 8   5   5   ILE ILE A . n 
A 1 9   LYS 9   6   6   LYS LYS A . n 
A 1 10  VAL 10  7   7   VAL VAL A . n 
A 1 11  PHE 11  8   8   PHE PHE A . n 
A 1 12  THR 12  9   9   THR THR A . n 
A 1 13  THR 13  10  10  THR THR A . n 
A 1 14  VAL 14  11  11  VAL VAL A . n 
A 1 15  ASP 15  12  12  ASP ASP A . n 
A 1 16  ASN 16  13  13  ASN ASN A . n 
A 1 17  ILE 17  14  14  ILE ILE A . n 
A 1 18  ASN 18  15  15  ASN ASN A . n 
A 1 19  LEU 19  16  16  LEU LEU A . n 
A 1 20  HIS 20  17  17  HIS HIS A . n 
A 1 21  THR 21  18  18  THR THR A . n 
A 1 22  GLN 22  19  19  GLN GLN A . n 
A 1 23  VAL 23  20  20  VAL VAL A . n 
A 1 24  VAL 24  21  21  VAL VAL A . n 
A 1 25  ASP 25  22  22  ASP ASP A . n 
A 1 26  MET 26  23  23  MET MET A . n 
A 1 27  SER 27  24  24  SER SER A . n 
A 1 28  MET 28  25  25  MET MET A . n 
A 1 29  THR 29  26  26  THR THR A . n 
A 1 30  TYR 30  27  27  TYR TYR A . n 
A 1 31  GLY 31  28  28  GLY GLY A . n 
A 1 32  GLN 32  29  29  GLN GLN A . n 
A 1 33  GLN 33  30  30  GLN GLN A . n 
A 1 34  PHE 34  31  31  PHE PHE A . n 
A 1 35  GLY 35  32  32  GLY GLY A . n 
A 1 36  PRO 36  33  33  PRO PRO A . n 
A 1 37  THR 37  34  34  THR THR A . n 
A 1 38  TYR 38  35  35  TYR TYR A . n 
A 1 39  LEU 39  36  36  LEU LEU A . n 
A 1 40  ASP 40  37  37  ASP ASP A . n 
A 1 41  GLY 41  38  38  GLY GLY A . n 
A 1 42  ALA 42  39  39  ALA ALA A . n 
A 1 43  ASP 43  40  40  ASP ASP A . n 
A 1 44  VAL 44  41  41  VAL VAL A . n 
A 1 45  THR 45  42  42  THR THR A . n 
A 1 46  LYS 46  43  43  LYS LYS A . n 
A 1 47  ILE 47  44  44  ILE ILE A . n 
A 1 48  LYS 48  45  45  LYS LYS A . n 
A 1 49  PRO 49  46  46  PRO PRO A . n 
A 1 50  HIS 50  47  47  HIS HIS A . n 
A 1 51  ASN 51  48  48  ASN ASN A . n 
A 1 52  SER 52  49  49  SER SER A . n 
A 1 53  HIS 53  50  50  HIS HIS A . n 
A 1 54  GLU 54  51  51  GLU GLU A . n 
A 1 55  GLY 55  52  52  GLY GLY A . n 
A 1 56  LYS 56  53  53  LYS LYS A . n 
A 1 57  THR 57  54  54  THR THR A . n 
A 1 58  PHE 58  55  55  PHE PHE A . n 
A 1 59  TYR 59  56  56  TYR TYR A . n 
A 1 60  VAL 60  57  57  VAL VAL A . n 
A 1 61  LEU 61  58  58  LEU LEU A . n 
A 1 62  PRO 62  59  59  PRO PRO A . n 
A 1 63  ASN 63  60  60  ASN ASN A . n 
A 1 64  ASP 64  61  61  ASP ASP A . n 
A 1 65  ASP 65  62  62  ASP ASP A . n 
A 1 66  THR 66  63  63  THR THR A . n 
A 1 67  LEU 67  64  64  LEU LEU A . n 
A 1 68  ARG 68  65  65  ARG ARG A . n 
A 1 69  VAL 69  66  66  VAL VAL A . n 
A 1 70  GLU 70  67  67  GLU GLU A . n 
A 1 71  ALA 71  68  68  ALA ALA A . n 
A 1 72  PHE 72  69  69  PHE PHE A . n 
A 1 73  GLU 73  70  70  GLU GLU A . n 
A 1 74  TYR 74  71  71  TYR TYR A . n 
A 1 75  TYR 75  72  72  TYR TYR A . n 
A 1 76  HIS 76  73  73  HIS HIS A . n 
A 1 77  THR 77  74  74  THR THR A . n 
A 1 78  THR 78  75  75  THR THR A . n 
A 1 79  ASP 79  76  76  ASP ASP A . n 
A 1 80  PRO 80  77  77  PRO PRO A . n 
A 1 81  SER 81  78  78  SER SER A . n 
A 1 82  PHE 82  79  79  PHE PHE A . n 
A 1 83  LEU 83  80  80  LEU LEU A . n 
A 1 84  GLY 84  81  81  GLY GLY A . n 
A 1 85  ARG 85  82  82  ARG ARG A . n 
A 1 86  TYR 86  83  83  TYR TYR A . n 
A 1 87  MET 87  84  84  MET MET A . n 
A 1 88  SER 88  85  85  SER SER A . n 
A 1 89  ALA 89  86  86  ALA ALA A . n 
A 1 90  LEU 90  87  87  LEU LEU A . n 
A 1 91  ASN 91  88  88  ASN ASN A . n 
A 1 92  HIS 92  89  89  HIS HIS A . n 
A 1 93  THR 93  90  90  THR THR A . n 
A 1 94  LYS 94  91  91  LYS LYS A . n 
A 1 95  LYS 95  92  92  LYS LYS A . n 
A 1 96  TRP 96  93  93  TRP TRP A . n 
A 1 97  LYS 97  94  94  LYS LYS A . n 
A 1 98  TYR 98  95  95  TYR TYR A . n 
A 1 99  PRO 99  96  96  PRO PRO A . n 
A 1 100 GLN 100 97  97  GLN GLN A . n 
A 1 101 VAL 101 98  98  VAL VAL A . n 
A 1 102 ASN 102 99  99  ASN ASN A . n 
A 1 103 GLY 103 100 100 GLY GLY A . n 
A 1 104 LEU 104 101 101 LEU LEU A . n 
A 1 105 THR 105 102 102 THR THR A . n 
A 1 106 SER 106 103 103 SER SER A . n 
A 1 107 ILE 107 104 104 ILE ILE A . n 
A 1 108 LYS 108 105 105 LYS LYS A . n 
A 1 109 TRP 109 106 106 TRP TRP A . n 
A 1 110 ALA 110 107 107 ALA ALA A . n 
A 1 111 ASP 111 108 108 ASP ASP A . n 
A 1 112 ASN 112 109 109 ASN ASN A . n 
A 1 113 ASN 113 110 110 ASN ASN A . n 
A 1 114 CYS 114 111 111 CYS CYS A . n 
A 1 115 TYR 115 112 112 TYR TYR A . n 
A 1 116 LEU 116 113 113 LEU LEU A . n 
A 1 117 ALA 117 114 114 ALA ALA A . n 
A 1 118 THR 118 115 115 THR THR A . n 
A 1 119 ALA 119 116 116 ALA ALA A . n 
A 1 120 LEU 120 117 117 LEU LEU A . n 
A 1 121 LEU 121 118 118 LEU LEU A . n 
A 1 122 THR 122 119 119 THR THR A . n 
A 1 123 LEU 123 120 120 LEU LEU A . n 
A 1 124 GLN 124 121 121 GLN GLN A . n 
A 1 125 GLN 125 122 122 GLN GLN A . n 
A 1 126 ILE 126 123 123 ILE ILE A . n 
A 1 127 GLU 127 124 124 GLU GLU A . n 
A 1 128 LEU 128 125 125 LEU LEU A . n 
A 1 129 LYS 129 126 126 LYS LYS A . n 
A 1 130 PHE 130 127 127 PHE PHE A . n 
A 1 131 ASN 131 128 128 ASN ASN A . n 
A 1 132 PRO 132 129 129 PRO PRO A . n 
A 1 133 PRO 133 130 130 PRO PRO A . n 
A 1 134 ALA 134 131 131 ALA ALA A . n 
A 1 135 LEU 135 132 132 LEU LEU A . n 
A 1 136 GLN 136 133 133 GLN GLN A . n 
A 1 137 ASP 137 134 134 ASP ASP A . n 
A 1 138 ALA 138 135 135 ALA ALA A . n 
A 1 139 TYR 139 136 136 TYR TYR A . n 
A 1 140 TYR 140 137 137 TYR TYR A . n 
A 1 141 ARG 141 138 138 ARG ARG A . n 
A 1 142 ALA 142 139 139 ALA ALA A . n 
A 1 143 ARG 143 140 140 ARG ARG A . n 
A 1 144 ALA 144 141 141 ALA ALA A . n 
A 1 145 GLY 145 142 142 GLY GLY A . n 
A 1 146 GLU 146 143 143 GLU GLU A . n 
A 1 147 ALA 147 144 144 ALA ALA A . n 
A 1 148 ALA 148 145 145 ALA ALA A . n 
A 1 149 ASN 149 146 146 ASN ASN A . n 
A 1 150 PHE 150 147 147 PHE PHE A . n 
A 1 151 CYS 151 148 148 CYS CYS A . n 
A 1 152 ALA 152 149 149 ALA ALA A . n 
A 1 153 LEU 153 150 150 LEU LEU A . n 
A 1 154 ILE 154 151 151 ILE ILE A . n 
A 1 155 LEU 155 152 152 LEU LEU A . n 
A 1 156 ALA 156 153 153 ALA ALA A . n 
A 1 157 TYR 157 154 154 TYR TYR A . n 
A 1 158 CYS 158 155 155 CYS CYS A . n 
A 1 159 ASN 159 156 156 ASN ASN A . n 
A 1 160 LYS 160 157 157 LYS LYS A . n 
A 1 161 THR 161 158 158 THR THR A . n 
A 1 162 VAL 162 159 159 VAL VAL A . n 
A 1 163 GLY 163 160 160 GLY GLY A . n 
A 1 164 GLU 164 161 161 GLU GLU A . n 
A 1 165 LEU 165 162 162 LEU LEU A . n 
A 1 166 GLY 166 163 163 GLY GLY A . n 
A 1 167 ASP 167 164 164 ASP ASP A . n 
A 1 168 VAL 168 165 165 VAL VAL A . n 
A 1 169 ARG 169 166 166 ARG ARG A . n 
A 1 170 GLU 170 167 167 GLU GLU A . n 
A 1 171 THR 171 168 168 THR THR A . n 
A 1 172 MET 172 169 169 MET MET A . n 
A 1 173 SER 173 170 170 SER SER A . n 
A 1 174 TYR 174 171 171 TYR TYR A . n 
A 1 175 LEU 175 172 172 LEU LEU A . n 
A 1 176 PHE 176 173 173 PHE PHE A . n 
A 1 177 GLN 177 174 174 GLN GLN A . n 
A 1 178 HIS 178 175 175 HIS HIS A . n 
A 1 179 ALA 179 176 176 ALA ALA A . n 
A 1 180 ASN 180 177 177 ASN ASN A . n 
A 1 181 LEU 181 178 178 LEU LEU A . n 
A 1 182 ASP 182 179 179 ASP ASP A . n 
A 1 183 SER 183 180 180 SER SER A . n 
A 1 184 CYS 184 181 181 CYS CYS A . n 
A 1 185 LYS 185 182 182 LYS LYS A . n 
A 1 186 ARG 186 183 183 ARG ARG A . n 
A 1 187 VAL 187 184 184 VAL VAL A . n 
A 1 188 LEU 188 185 185 LEU LEU A . n 
A 1 189 ASN 189 186 186 ASN ASN A . n 
A 1 190 VAL 190 187 187 VAL VAL A . n 
A 1 191 VAL 191 188 188 VAL VAL A . n 
A 1 192 CYS 192 189 189 CYS CYS A . n 
A 1 193 LYS 193 190 190 LYS LYS A . n 
A 1 194 THR 194 191 191 THR THR A . n 
A 1 195 CYS 195 192 192 CYS CYS A . n 
A 1 196 GLY 196 193 193 GLY GLY A . n 
A 1 197 GLN 197 194 194 GLN GLN A . n 
A 1 198 GLN 198 195 195 GLN GLN A . n 
A 1 199 GLN 199 196 196 GLN GLN A . n 
A 1 200 THR 200 197 197 THR THR A . n 
A 1 201 THR 201 198 198 THR THR A . n 
A 1 202 LEU 202 199 199 LEU LEU A . n 
A 1 203 LYS 203 200 200 LYS LYS A . n 
A 1 204 GLY 204 201 201 GLY GLY A . n 
A 1 205 VAL 205 202 202 VAL VAL A . n 
A 1 206 GLU 206 203 203 GLU GLU A . n 
A 1 207 ALA 207 204 204 ALA ALA A . n 
A 1 208 VAL 208 205 205 VAL VAL A . n 
A 1 209 MET 209 206 206 MET MET A . n 
A 1 210 TYR 210 207 207 TYR TYR A . n 
A 1 211 MET 211 208 208 MET MET A . n 
A 1 212 GLY 212 209 209 GLY GLY A . n 
A 1 213 THR 213 210 210 THR THR A . n 
A 1 214 LEU 214 211 211 LEU LEU A . n 
A 1 215 SER 215 212 212 SER SER A . n 
A 1 216 TYR 216 213 213 TYR TYR A . n 
A 1 217 GLU 217 214 214 GLU GLU A . n 
A 1 218 GLN 218 215 215 GLN GLN A . n 
A 1 219 PHE 219 216 216 PHE PHE A . n 
A 1 220 LYS 220 217 217 LYS LYS A . n 
A 1 221 LYS 221 218 218 LYS LYS A . n 
A 1 222 GLY 222 219 219 GLY GLY A . n 
A 1 223 VAL 223 220 220 VAL VAL A . n 
A 1 224 GLN 224 221 221 GLN GLN A . n 
A 1 225 ILE 225 222 222 ILE ILE A . n 
A 1 226 PRO 226 223 223 PRO PRO A . n 
A 1 227 CYS 227 224 224 CYS CYS A . n 
A 1 228 THR 228 225 225 THR THR A . n 
A 1 229 CYS 229 226 226 CYS CYS A . n 
A 1 230 GLY 230 227 227 GLY GLY A . n 
A 1 231 LYS 231 228 228 LYS LYS A . n 
A 1 232 GLN 232 229 229 GLN GLN A . n 
A 1 233 ALA 233 230 230 ALA ALA A . n 
A 1 234 THR 234 231 231 THR THR A . n 
A 1 235 LYS 235 232 232 LYS LYS A . n 
A 1 236 TYR 236 233 233 TYR TYR A . n 
A 1 237 LEU 237 234 234 LEU LEU A . n 
A 1 238 VAL 238 235 235 VAL VAL A . n 
A 1 239 GLN 239 236 236 GLN GLN A . n 
A 1 240 GLN 240 237 237 GLN GLN A . n 
A 1 241 GLU 241 238 238 GLU GLU A . n 
A 1 242 SER 242 239 239 SER SER A . n 
A 1 243 PRO 243 240 240 PRO PRO A . n 
A 1 244 PHE 244 241 241 PHE PHE A . n 
A 1 245 VAL 245 242 242 VAL VAL A . n 
A 1 246 MET 246 243 243 MET MET A . n 
A 1 247 MET 247 244 244 MET MET A . n 
A 1 248 SER 248 245 245 SER SER A . n 
A 1 249 ALA 249 246 246 ALA ALA A . n 
A 1 250 PRO 250 247 247 PRO PRO A . n 
A 1 251 PRO 251 248 248 PRO PRO A . n 
A 1 252 ALA 252 249 249 ALA ALA A . n 
A 1 253 GLN 253 250 250 GLN GLN A . n 
A 1 254 TYR 254 251 251 TYR TYR A . n 
A 1 255 GLU 255 252 252 GLU GLU A . n 
A 1 256 LEU 256 253 253 LEU LEU A . n 
A 1 257 LYS 257 254 254 LYS LYS A . n 
A 1 258 HIS 258 255 255 HIS HIS A . n 
A 1 259 GLY 259 256 256 GLY GLY A . n 
A 1 260 THR 260 257 257 THR THR A . n 
A 1 261 PHE 261 258 258 PHE PHE A . n 
A 1 262 THR 262 259 259 THR THR A . n 
A 1 263 CYS 263 260 260 CYS CYS A . n 
A 1 264 ALA 264 261 261 ALA ALA A . n 
A 1 265 SER 265 262 262 SER SER A . n 
A 1 266 GLU 266 263 263 GLU GLU A . n 
A 1 267 TYR 267 264 264 TYR TYR A . n 
A 1 268 THR 268 265 265 THR THR A . n 
A 1 269 GLY 269 266 266 GLY GLY A . n 
A 1 270 ASN 270 267 267 ASN ASN A . n 
A 1 271 TYR 271 268 268 TYR TYR A . n 
A 1 272 GLN 272 269 269 GLN GLN A . n 
A 1 273 CYS 273 270 270 CYS CYS A . n 
A 1 274 GLY 274 271 271 GLY GLY A . n 
A 1 275 HIS 275 272 272 HIS HIS A . n 
A 1 276 TYR 276 273 273 TYR TYR A . n 
A 1 277 LYS 277 274 274 LYS LYS A . n 
A 1 278 HIS 278 275 275 HIS HIS A . n 
A 1 279 ILE 279 276 276 ILE ILE A . n 
A 1 280 THR 280 277 277 THR THR A . n 
A 1 281 SER 281 278 278 SER SER A . n 
A 1 282 LYS 282 279 279 LYS LYS A . n 
A 1 283 GLU 283 280 280 GLU GLU A . n 
A 1 284 THR 284 281 281 THR THR A . n 
A 1 285 LEU 285 282 282 LEU LEU A . n 
A 1 286 TYR 286 283 283 TYR TYR A . n 
A 1 287 CYS 287 284 284 CYS CYS A . n 
A 1 288 ILE 288 285 285 ILE ILE A . n 
A 1 289 ASP 289 286 286 ASP ASP A . n 
A 1 290 GLY 290 287 287 GLY GLY A . n 
A 1 291 ALA 291 288 288 ALA ALA A . n 
A 1 292 LEU 292 289 289 LEU LEU A . n 
A 1 293 LEU 293 290 290 LEU LEU A . n 
A 1 294 THR 294 291 291 THR THR A . n 
A 1 295 LYS 295 292 292 LYS LYS A . n 
A 1 296 SER 296 293 293 SER SER A . n 
A 1 297 SER 297 294 294 SER SER A . n 
A 1 298 GLU 298 295 295 GLU GLU A . n 
A 1 299 TYR 299 296 296 TYR TYR A . n 
A 1 300 LYS 300 297 297 LYS LYS A . n 
A 1 301 GLY 301 298 298 GLY GLY A . n 
A 1 302 PRO 302 299 299 PRO PRO A . n 
A 1 303 ILE 303 300 300 ILE ILE A . n 
A 1 304 THR 304 301 301 THR THR A . n 
A 1 305 ASP 305 302 302 ASP ASP A . n 
A 1 306 VAL 306 303 303 VAL VAL A . n 
A 1 307 PHE 307 304 304 PHE PHE A . n 
A 1 308 TYR 308 305 305 TYR TYR A . n 
A 1 309 LYS 309 306 306 LYS LYS A . n 
A 1 310 GLU 310 307 307 GLU GLU A . n 
A 1 311 ASN 311 308 308 ASN ASN A . n 
A 1 312 SER 312 309 309 SER SER A . n 
A 1 313 TYR 313 310 310 TYR TYR A . n 
A 1 314 THR 314 311 311 THR THR A . n 
A 1 315 THR 315 312 312 THR THR A . n 
A 1 316 THR 316 313 313 THR THR A . n 
A 1 317 ILE 317 314 314 ILE ILE A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   401 1   ZN  ZN  A . 
C 3 PO4 1   402 2   PO4 PO4 A . 
D 3 PO4 1   403 3   PO4 PO4 A . 
E 4 GOL 1   404 1   GOL GOL A . 
F 4 GOL 1   405 2   GOL GOL A . 
G 4 GOL 1   406 3   GOL GOL A . 
H 4 GOL 1   407 4   GOL GOL A . 
I 4 GOL 1   408 5   GOL GOL A . 
J 5 HOH 1   501 628 HOH HOH A . 
J 5 HOH 2   502 543 HOH HOH A . 
J 5 HOH 3   503 176 HOH HOH A . 
J 5 HOH 4   504 23  HOH HOH A . 
J 5 HOH 5   505 585 HOH HOH A . 
J 5 HOH 6   506 172 HOH HOH A . 
J 5 HOH 7   507 200 HOH HOH A . 
J 5 HOH 8   508 556 HOH HOH A . 
J 5 HOH 9   509 88  HOH HOH A . 
J 5 HOH 10  510 573 HOH HOH A . 
J 5 HOH 11  511 552 HOH HOH A . 
J 5 HOH 12  512 571 HOH HOH A . 
J 5 HOH 13  513 182 HOH HOH A . 
J 5 HOH 14  514 28  HOH HOH A . 
J 5 HOH 15  515 144 HOH HOH A . 
J 5 HOH 16  516 222 HOH HOH A . 
J 5 HOH 17  517 63  HOH HOH A . 
J 5 HOH 18  518 564 HOH HOH A . 
J 5 HOH 19  519 226 HOH HOH A . 
J 5 HOH 20  520 590 HOH HOH A . 
J 5 HOH 21  521 53  HOH HOH A . 
J 5 HOH 22  522 71  HOH HOH A . 
J 5 HOH 23  523 97  HOH HOH A . 
J 5 HOH 24  524 70  HOH HOH A . 
J 5 HOH 25  525 202 HOH HOH A . 
J 5 HOH 26  526 243 HOH HOH A . 
J 5 HOH 27  527 224 HOH HOH A . 
J 5 HOH 28  528 119 HOH HOH A . 
J 5 HOH 29  529 163 HOH HOH A . 
J 5 HOH 30  530 32  HOH HOH A . 
J 5 HOH 31  531 233 HOH HOH A . 
J 5 HOH 32  532 117 HOH HOH A . 
J 5 HOH 33  533 553 HOH HOH A . 
J 5 HOH 34  534 40  HOH HOH A . 
J 5 HOH 35  535 520 HOH HOH A . 
J 5 HOH 36  536 154 HOH HOH A . 
J 5 HOH 37  537 27  HOH HOH A . 
J 5 HOH 38  538 116 HOH HOH A . 
J 5 HOH 39  539 100 HOH HOH A . 
J 5 HOH 40  540 207 HOH HOH A . 
J 5 HOH 41  541 127 HOH HOH A . 
J 5 HOH 42  542 610 HOH HOH A . 
J 5 HOH 43  543 69  HOH HOH A . 
J 5 HOH 44  544 4   HOH HOH A . 
J 5 HOH 45  545 103 HOH HOH A . 
J 5 HOH 46  546 386 HOH HOH A . 
J 5 HOH 47  547 74  HOH HOH A . 
J 5 HOH 48  548 146 HOH HOH A . 
J 5 HOH 49  549 19  HOH HOH A . 
J 5 HOH 50  550 55  HOH HOH A . 
J 5 HOH 51  551 14  HOH HOH A . 
J 5 HOH 52  552 524 HOH HOH A . 
J 5 HOH 53  553 130 HOH HOH A . 
J 5 HOH 54  554 620 HOH HOH A . 
J 5 HOH 55  555 165 HOH HOH A . 
J 5 HOH 56  556 217 HOH HOH A . 
J 5 HOH 57  557 108 HOH HOH A . 
J 5 HOH 58  558 371 HOH HOH A . 
J 5 HOH 59  559 82  HOH HOH A . 
J 5 HOH 60  560 77  HOH HOH A . 
J 5 HOH 61  561 153 HOH HOH A . 
J 5 HOH 62  562 51  HOH HOH A . 
J 5 HOH 63  563 136 HOH HOH A . 
J 5 HOH 64  564 229 HOH HOH A . 
J 5 HOH 65  565 72  HOH HOH A . 
J 5 HOH 66  566 316 HOH HOH A . 
J 5 HOH 67  567 186 HOH HOH A . 
J 5 HOH 68  568 75  HOH HOH A . 
J 5 HOH 69  569 38  HOH HOH A . 
J 5 HOH 70  570 16  HOH HOH A . 
J 5 HOH 71  571 156 HOH HOH A . 
J 5 HOH 72  572 92  HOH HOH A . 
J 5 HOH 73  573 142 HOH HOH A . 
J 5 HOH 74  574 190 HOH HOH A . 
J 5 HOH 75  575 140 HOH HOH A . 
J 5 HOH 76  576 193 HOH HOH A . 
J 5 HOH 77  577 174 HOH HOH A . 
J 5 HOH 78  578 13  HOH HOH A . 
J 5 HOH 79  579 567 HOH HOH A . 
J 5 HOH 80  580 10  HOH HOH A . 
J 5 HOH 81  581 531 HOH HOH A . 
J 5 HOH 82  582 24  HOH HOH A . 
J 5 HOH 83  583 185 HOH HOH A . 
J 5 HOH 84  584 134 HOH HOH A . 
J 5 HOH 85  585 364 HOH HOH A . 
J 5 HOH 86  586 377 HOH HOH A . 
J 5 HOH 87  587 80  HOH HOH A . 
J 5 HOH 88  588 466 HOH HOH A . 
J 5 HOH 89  589 1   HOH HOH A . 
J 5 HOH 90  590 21  HOH HOH A . 
J 5 HOH 91  591 141 HOH HOH A . 
J 5 HOH 92  592 517 HOH HOH A . 
J 5 HOH 93  593 401 HOH HOH A . 
J 5 HOH 94  594 537 HOH HOH A . 
J 5 HOH 95  595 379 HOH HOH A . 
J 5 HOH 96  596 159 HOH HOH A . 
J 5 HOH 97  597 471 HOH HOH A . 
J 5 HOH 98  598 152 HOH HOH A . 
J 5 HOH 99  599 168 HOH HOH A . 
J 5 HOH 100 600 68  HOH HOH A . 
J 5 HOH 101 601 58  HOH HOH A . 
J 5 HOH 102 602 533 HOH HOH A . 
J 5 HOH 103 603 535 HOH HOH A . 
J 5 HOH 104 604 627 HOH HOH A . 
J 5 HOH 105 605 65  HOH HOH A . 
J 5 HOH 106 606 50  HOH HOH A . 
J 5 HOH 107 607 12  HOH HOH A . 
J 5 HOH 108 608 35  HOH HOH A . 
J 5 HOH 109 609 2   HOH HOH A . 
J 5 HOH 110 610 123 HOH HOH A . 
J 5 HOH 111 611 114 HOH HOH A . 
J 5 HOH 112 612 64  HOH HOH A . 
J 5 HOH 113 613 67  HOH HOH A . 
J 5 HOH 114 614 311 HOH HOH A . 
J 5 HOH 115 615 118 HOH HOH A . 
J 5 HOH 116 616 109 HOH HOH A . 
J 5 HOH 117 617 241 HOH HOH A . 
J 5 HOH 118 618 62  HOH HOH A . 
J 5 HOH 119 619 6   HOH HOH A . 
J 5 HOH 120 620 33  HOH HOH A . 
J 5 HOH 121 621 101 HOH HOH A . 
J 5 HOH 122 622 394 HOH HOH A . 
J 5 HOH 123 623 122 HOH HOH A . 
J 5 HOH 124 624 132 HOH HOH A . 
J 5 HOH 125 625 15  HOH HOH A . 
J 5 HOH 126 626 34  HOH HOH A . 
J 5 HOH 127 627 110 HOH HOH A . 
J 5 HOH 128 628 175 HOH HOH A . 
J 5 HOH 129 629 20  HOH HOH A . 
J 5 HOH 130 630 235 HOH HOH A . 
J 5 HOH 131 631 626 HOH HOH A . 
J 5 HOH 132 632 197 HOH HOH A . 
J 5 HOH 133 633 131 HOH HOH A . 
J 5 HOH 134 634 45  HOH HOH A . 
J 5 HOH 135 635 557 HOH HOH A . 
J 5 HOH 136 636 17  HOH HOH A . 
J 5 HOH 137 637 526 HOH HOH A . 
J 5 HOH 138 638 151 HOH HOH A . 
J 5 HOH 139 639 614 HOH HOH A . 
J 5 HOH 140 640 575 HOH HOH A . 
J 5 HOH 141 641 584 HOH HOH A . 
J 5 HOH 142 642 42  HOH HOH A . 
J 5 HOH 143 643 208 HOH HOH A . 
J 5 HOH 144 644 43  HOH HOH A . 
J 5 HOH 145 645 120 HOH HOH A . 
J 5 HOH 146 646 167 HOH HOH A . 
J 5 HOH 147 647 568 HOH HOH A . 
J 5 HOH 148 648 587 HOH HOH A . 
J 5 HOH 149 649 373 HOH HOH A . 
J 5 HOH 150 650 29  HOH HOH A . 
J 5 HOH 151 651 492 HOH HOH A . 
J 5 HOH 152 652 126 HOH HOH A . 
J 5 HOH 153 653 315 HOH HOH A . 
J 5 HOH 154 654 79  HOH HOH A . 
J 5 HOH 155 655 188 HOH HOH A . 
J 5 HOH 156 656 606 HOH HOH A . 
J 5 HOH 157 657 11  HOH HOH A . 
J 5 HOH 158 658 91  HOH HOH A . 
J 5 HOH 159 659 60  HOH HOH A . 
J 5 HOH 160 660 618 HOH HOH A . 
J 5 HOH 161 661 518 HOH HOH A . 
J 5 HOH 162 662 621 HOH HOH A . 
J 5 HOH 163 663 230 HOH HOH A . 
J 5 HOH 164 664 530 HOH HOH A . 
J 5 HOH 165 665 166 HOH HOH A . 
J 5 HOH 166 666 245 HOH HOH A . 
J 5 HOH 167 667 588 HOH HOH A . 
J 5 HOH 168 668 113 HOH HOH A . 
J 5 HOH 169 669 284 HOH HOH A . 
J 5 HOH 170 670 576 HOH HOH A . 
J 5 HOH 171 671 26  HOH HOH A . 
J 5 HOH 172 672 191 HOH HOH A . 
J 5 HOH 173 673 52  HOH HOH A . 
J 5 HOH 174 674 87  HOH HOH A . 
J 5 HOH 175 675 138 HOH HOH A . 
J 5 HOH 176 676 8   HOH HOH A . 
J 5 HOH 177 677 458 HOH HOH A . 
J 5 HOH 178 678 171 HOH HOH A . 
J 5 HOH 179 679 25  HOH HOH A . 
J 5 HOH 180 680 73  HOH HOH A . 
J 5 HOH 181 681 66  HOH HOH A . 
J 5 HOH 182 682 124 HOH HOH A . 
J 5 HOH 183 683 36  HOH HOH A . 
J 5 HOH 184 684 413 HOH HOH A . 
J 5 HOH 185 685 198 HOH HOH A . 
J 5 HOH 186 686 220 HOH HOH A . 
J 5 HOH 187 687 48  HOH HOH A . 
J 5 HOH 188 688 9   HOH HOH A . 
J 5 HOH 189 689 219 HOH HOH A . 
J 5 HOH 190 690 49  HOH HOH A . 
J 5 HOH 191 691 31  HOH HOH A . 
J 5 HOH 192 692 3   HOH HOH A . 
J 5 HOH 193 693 570 HOH HOH A . 
J 5 HOH 194 694 591 HOH HOH A . 
J 5 HOH 195 695 39  HOH HOH A . 
J 5 HOH 196 696 583 HOH HOH A . 
J 5 HOH 197 697 608 HOH HOH A . 
J 5 HOH 198 698 18  HOH HOH A . 
J 5 HOH 199 699 47  HOH HOH A . 
J 5 HOH 200 700 547 HOH HOH A . 
J 5 HOH 201 701 7   HOH HOH A . 
J 5 HOH 202 702 534 HOH HOH A . 
J 5 HOH 203 703 133 HOH HOH A . 
J 5 HOH 204 704 461 HOH HOH A . 
J 5 HOH 205 705 46  HOH HOH A . 
J 5 HOH 206 706 611 HOH HOH A . 
J 5 HOH 207 707 353 HOH HOH A . 
J 5 HOH 208 708 41  HOH HOH A . 
J 5 HOH 209 709 271 HOH HOH A . 
J 5 HOH 210 710 94  HOH HOH A . 
J 5 HOH 211 711 59  HOH HOH A . 
J 5 HOH 212 712 210 HOH HOH A . 
J 5 HOH 213 713 83  HOH HOH A . 
J 5 HOH 214 714 95  HOH HOH A . 
J 5 HOH 215 715 613 HOH HOH A . 
J 5 HOH 216 716 538 HOH HOH A . 
J 5 HOH 217 717 215 HOH HOH A . 
J 5 HOH 218 718 544 HOH HOH A . 
J 5 HOH 219 719 44  HOH HOH A . 
J 5 HOH 220 720 37  HOH HOH A . 
J 5 HOH 221 721 485 HOH HOH A . 
J 5 HOH 222 722 453 HOH HOH A . 
J 5 HOH 223 723 351 HOH HOH A . 
J 5 HOH 224 724 498 HOH HOH A . 
J 5 HOH 225 725 292 HOH HOH A . 
J 5 HOH 226 726 254 HOH HOH A . 
J 5 HOH 227 727 617 HOH HOH A . 
J 5 HOH 228 728 623 HOH HOH A . 
J 5 HOH 229 729 129 HOH HOH A . 
J 5 HOH 230 730 612 HOH HOH A . 
J 5 HOH 231 731 474 HOH HOH A . 
J 5 HOH 232 732 347 HOH HOH A . 
J 5 HOH 233 733 574 HOH HOH A . 
J 5 HOH 234 734 57  HOH HOH A . 
J 5 HOH 235 735 512 HOH HOH A . 
J 5 HOH 236 736 462 HOH HOH A . 
J 5 HOH 237 737 589 HOH HOH A . 
J 5 HOH 238 738 128 HOH HOH A . 
J 5 HOH 239 739 276 HOH HOH A . 
J 5 HOH 240 740 625 HOH HOH A . 
J 5 HOH 241 741 559 HOH HOH A . 
J 5 HOH 242 742 409 HOH HOH A . 
J 5 HOH 243 743 546 HOH HOH A . 
J 5 HOH 244 744 251 HOH HOH A . 
J 5 HOH 245 745 519 HOH HOH A . 
J 5 HOH 246 746 539 HOH HOH A . 
J 5 HOH 247 747 581 HOH HOH A . 
J 5 HOH 248 748 5   HOH HOH A . 
J 5 HOH 249 749 343 HOH HOH A . 
J 5 HOH 250 750 550 HOH HOH A . 
J 5 HOH 251 751 145 HOH HOH A . 
J 5 HOH 252 752 598 HOH HOH A . 
J 5 HOH 253 753 456 HOH HOH A . 
J 5 HOH 254 754 225 HOH HOH A . 
J 5 HOH 255 755 467 HOH HOH A . 
J 5 HOH 256 756 115 HOH HOH A . 
J 5 HOH 257 757 389 HOH HOH A . 
J 5 HOH 258 758 616 HOH HOH A . 
J 5 HOH 259 759 555 HOH HOH A . 
J 5 HOH 260 760 599 HOH HOH A . 
J 5 HOH 261 761 205 HOH HOH A . 
J 5 HOH 262 762 162 HOH HOH A . 
J 5 HOH 263 763 545 HOH HOH A . 
J 5 HOH 264 764 541 HOH HOH A . 
J 5 HOH 265 765 125 HOH HOH A . 
J 5 HOH 266 766 194 HOH HOH A . 
J 5 HOH 267 767 561 HOH HOH A . 
J 5 HOH 268 768 365 HOH HOH A . 
J 5 HOH 269 769 502 HOH HOH A . 
J 5 HOH 270 770 149 HOH HOH A . 
J 5 HOH 271 771 558 HOH HOH A . 
J 5 HOH 272 772 147 HOH HOH A . 
J 5 HOH 273 773 356 HOH HOH A . 
J 5 HOH 274 774 527 HOH HOH A . 
J 5 HOH 275 775 155 HOH HOH A . 
J 5 HOH 276 776 540 HOH HOH A . 
J 5 HOH 277 777 548 HOH HOH A . 
J 5 HOH 278 778 148 HOH HOH A . 
J 5 HOH 279 779 493 HOH HOH A . 
J 5 HOH 280 780 586 HOH HOH A . 
J 5 HOH 281 781 212 HOH HOH A . 
J 5 HOH 282 782 495 HOH HOH A . 
J 5 HOH 283 783 187 HOH HOH A . 
J 5 HOH 284 784 314 HOH HOH A . 
J 5 HOH 285 785 560 HOH HOH A . 
J 5 HOH 286 786 170 HOH HOH A . 
J 5 HOH 287 787 594 HOH HOH A . 
J 5 HOH 288 788 223 HOH HOH A . 
J 5 HOH 289 789 184 HOH HOH A . 
J 5 HOH 290 790 363 HOH HOH A . 
J 5 HOH 291 791 86  HOH HOH A . 
J 5 HOH 292 792 505 HOH HOH A . 
J 5 HOH 293 793 500 HOH HOH A . 
J 5 HOH 294 794 78  HOH HOH A . 
J 5 HOH 295 795 593 HOH HOH A . 
J 5 HOH 296 796 624 HOH HOH A . 
J 5 HOH 297 797 325 HOH HOH A . 
J 5 HOH 298 798 619 HOH HOH A . 
J 5 HOH 299 799 528 HOH HOH A . 
J 5 HOH 300 800 551 HOH HOH A . 
J 5 HOH 301 801 554 HOH HOH A . 
J 5 HOH 302 802 569 HOH HOH A . 
J 5 HOH 303 803 514 HOH HOH A . 
J 5 HOH 304 804 177 HOH HOH A . 
J 5 HOH 305 805 169 HOH HOH A . 
J 5 HOH 306 806 160 HOH HOH A . 
J 5 HOH 307 807 218 HOH HOH A . 
J 5 HOH 308 808 181 HOH HOH A . 
J 5 HOH 309 809 532 HOH HOH A . 
J 5 HOH 310 810 158 HOH HOH A . 
J 5 HOH 311 811 106 HOH HOH A . 
J 5 HOH 312 812 301 HOH HOH A . 
J 5 HOH 313 813 237 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 ? 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           ? 2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           ? 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           ? 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9VAO 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     81.821 
_cell.length_a_esd                 ? 
_cell.length_b                     81.821 
_cell.length_b_esd                 ? 
_cell.length_c                     133.733 
_cell.length_c_esd                 ? 
_cell.volume                       775351.774 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9VAO 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            
;P 32 2"
;
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9VAO 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.60 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          65.83 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Tris buffer pH 8.0, Sodium dihydrogen phosphate/Potassium hydrogen phosphate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 R 1M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-19 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.3477 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'LIQUID ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'Excillum MetalJet D2+ 70 kV' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.3477 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          25.01 
_reflns.entry_id                                       9VAO 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.82 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     46912 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.05 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          27 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.82 
_reflns_shell.d_res_low                                     1.93 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             7375 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.81 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.1 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.36 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9VAO 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.82 
_refine.ls_d_res_low                             48.63 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     46907 
_refine.ls_number_reflns_R_free                  2006 
_refine.ls_number_reflns_R_work                  44901 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.04 
_refine.ls_percent_reflns_R_free                 4.28 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1901 
_refine.ls_R_factor_R_free                       0.2239 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1886 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.1515 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3212 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.82 
_refine_hist.d_res_low                        48.63 
_refine_hist.number_atoms_solvent             313 
_refine_hist.number_atoms_total               2870 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2516 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         41 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0083  ? 2666 ? f_bond_d           ? ? ? 
'X-RAY DIFFRACTION' ? 0.9190  ? 3619 ? f_angle_d          ? ? ? 
'X-RAY DIFFRACTION' ? 0.0537  ? 395  ? f_chiral_restr     ? ? ? 
'X-RAY DIFFRACTION' ? 0.0089  ? 460  ? f_plane_restr      ? ? ? 
'X-RAY DIFFRACTION' ? 15.6233 ? 972  ? f_dihedral_angle_d ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.82 1.86  . . 129 2848 89.94  . . . . 0.4754 . . . . . . . . . . . . . . . 0.4887 
'X-RAY DIFFRACTION' 1.86 1.91  . . 141 3197 99.67  . . . . 0.3723 . . . . . . . . . . . . . . . 0.3749 
'X-RAY DIFFRACTION' 1.91 1.97  . . 140 3184 99.64  . . . . 0.3133 . . . . . . . . . . . . . . . 0.3008 
'X-RAY DIFFRACTION' 1.97 2.03  . . 140 3187 99.61  . . . . 0.2822 . . . . . . . . . . . . . . . 0.3167 
'X-RAY DIFFRACTION' 2.03 2.10  . . 145 3183 99.82  . . . . 0.2711 . . . . . . . . . . . . . . . 0.3272 
'X-RAY DIFFRACTION' 2.10 2.19  . . 142 3185 99.31  . . . . 0.2199 . . . . . . . . . . . . . . . 0.2663 
'X-RAY DIFFRACTION' 2.19 2.29  . . 145 3211 99.85  . . . . 0.2110 . . . . . . . . . . . . . . . 0.2637 
'X-RAY DIFFRACTION' 2.29 2.41  . . 147 3234 99.94  . . . . 0.1903 . . . . . . . . . . . . . . . 0.2451 
'X-RAY DIFFRACTION' 2.41 2.56  . . 144 3208 99.97  . . . . 0.1825 . . . . . . . . . . . . . . . 0.2534 
'X-RAY DIFFRACTION' 2.56 2.76  . . 143 3222 99.97  . . . . 0.1735 . . . . . . . . . . . . . . . 0.2191 
'X-RAY DIFFRACTION' 2.76 3.04  . . 147 3262 100.00 . . . . 0.1765 . . . . . . . . . . . . . . . 0.2158 
'X-RAY DIFFRACTION' 3.04 3.47  . . 146 3258 99.85  . . . . 0.1470 . . . . . . . . . . . . . . . 0.1633 
'X-RAY DIFFRACTION' 3.47 4.38  . . 147 3285 99.59  . . . . 0.1392 . . . . . . . . . . . . . . . 0.1605 
'X-RAY DIFFRACTION' 4.38 48.63 . . 150 3437 99.31  . . . . 0.1546 . . . . . . . . . . . . . . . 0.1948 
# 
_struct.entry_id                     9VAO 
_struct.title                        'Crystal structure of Papain-like protease (PLpro) from SARS-CoV-2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9VAO 
_struct_keywords.text            'Cysteine Protease, PLpro, SARS-CoV-2, Ubl domain, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;EVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFL
GRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVG
ELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESP
FVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI
;
_struct_ref.pdbx_align_begin           1564 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9VAO 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 4 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 317 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  1564 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1877 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       314 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9VAO SER A 1 ? UNP P0DTD1 ? ? 'expression tag' -2 1 
1 9VAO HIS A 2 ? UNP P0DTD1 ? ? 'expression tag' -1 2 
1 9VAO MET A 3 ? UNP P0DTD1 ? ? 'expression tag' 0  3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 110   ? 
1 MORE         -3    ? 
1 'SSA (A^2)'  15720 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 29  ? GLY A 35  ? THR A 26  GLY A 32  1 ? 7  
HELX_P HELX_P2  AA2 HIS A 50  ? GLU A 54  ? HIS A 47  GLU A 51  5 ? 5  
HELX_P HELX_P3  AA3 ASP A 64  ? HIS A 76  ? ASP A 61  HIS A 73  1 ? 13 
HELX_P HELX_P4  AA4 SER A 81  ? LYS A 94  ? SER A 78  LYS A 91  1 ? 14 
HELX_P HELX_P5  AA5 ASN A 113 ? GLN A 124 ? ASN A 110 GLN A 121 1 ? 12 
HELX_P HELX_P6  AA6 PRO A 132 ? GLY A 145 ? PRO A 129 GLY A 142 1 ? 14 
HELX_P HELX_P7  AA7 ALA A 147 ? ASN A 159 ? ALA A 144 ASN A 156 1 ? 13 
HELX_P HELX_P8  AA8 ASP A 167 ? HIS A 178 ? ASP A 164 HIS A 175 1 ? 12 
HELX_P HELX_P9  AA9 GLY A 204 ? VAL A 208 ? GLY A 201 VAL A 205 1 ? 5  
HELX_P HELX_P10 AB1 SER A 215 ? GLY A 222 ? SER A 212 GLY A 219 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 192 SG ? ? ? 1_555 B ZN . ZN ? ? A CYS 189 A ZN 401 1_555 ? ? ? ? ? ? ? 2.296 ? ? 
metalc2 metalc ? ? A CYS 195 SG ? ? ? 1_555 B ZN . ZN ? ? A CYS 192 A ZN 401 1_555 ? ? ? ? ? ? ? 2.323 ? ? 
metalc3 metalc ? ? A CYS 227 SG ? ? ? 1_555 B ZN . ZN ? ? A CYS 224 A ZN 401 1_555 ? ? ? ? ? ? ? 2.342 ? ? 
metalc4 metalc ? ? A CYS 229 SG ? ? ? 1_555 B ZN . ZN ? ? A CYS 226 A ZN 401 1_555 ? ? ? ? ? ? ? 2.353 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 SG ? A CYS 192 ? A CYS 189 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 SG ? A CYS 195 ? A CYS 192 ? 1_555 115.4 ? 
2 SG ? A CYS 192 ? A CYS 189 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 SG ? A CYS 227 ? A CYS 224 ? 1_555 111.9 ? 
3 SG ? A CYS 195 ? A CYS 192 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 SG ? A CYS 227 ? A CYS 224 ? 1_555 106.1 ? 
4 SG ? A CYS 192 ? A CYS 189 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 SG ? A CYS 229 ? A CYS 226 ? 1_555 106.7 ? 
5 SG ? A CYS 195 ? A CYS 192 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 SG ? A CYS 229 ? A CYS 226 ? 1_555 109.7 ? 
6 SG ? A CYS 227 ? A CYS 224 ? 1_555 ZN ? B ZN . ? A ZN 401 ? 1_555 SG ? A CYS 229 ? A CYS 226 ? 1_555 106.8 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 HIS A 20  ? ASP A 25  ? HIS A 17  ASP A 22  
AA1 2 THR A 7   ? THR A 13  ? THR A 4   THR A 10  
AA1 3 THR A 57  ? VAL A 60  ? THR A 54  VAL A 57  
AA1 4 THR A 37  ? LEU A 39  ? THR A 34  LEU A 36  
AA1 5 ALA A 42  ? ASP A 43  ? ALA A 39  ASP A 40  
AA2 1 GLN A 100 ? VAL A 101 ? GLN A 97  VAL A 98  
AA2 2 LEU A 104 ? THR A 105 ? LEU A 101 THR A 102 
AA3 1 GLY A 196 ? LYS A 203 ? GLY A 193 LYS A 200 
AA3 2 LYS A 185 ? CYS A 192 ? LYS A 182 CYS A 189 
AA3 3 GLN A 232 ? GLU A 241 ? GLN A 229 GLU A 238 
AA3 4 VAL A 223 ? PRO A 226 ? VAL A 220 PRO A 223 
AA4 1 GLY A 196 ? LYS A 203 ? GLY A 193 LYS A 200 
AA4 2 LYS A 185 ? CYS A 192 ? LYS A 182 CYS A 189 
AA4 3 GLN A 232 ? GLU A 241 ? GLN A 229 GLU A 238 
AA4 4 SER A 312 ? THR A 314 ? SER A 309 THR A 311 
AA5 1 MET A 209 ? MET A 211 ? MET A 206 MET A 208 
AA5 2 PHE A 244 ? LYS A 257 ? PHE A 241 LYS A 254 
AA5 3 GLU A 298 ? LYS A 309 ? GLU A 295 LYS A 306 
AA5 4 CYS A 263 ? GLY A 269 ? CYS A 260 GLY A 266 
AA5 5 GLY A 274 ? SER A 281 ? GLY A 271 SER A 278 
AA5 6 LEU A 285 ? ASP A 289 ? LEU A 282 ASP A 286 
AA5 7 LEU A 292 ? SER A 296 ? LEU A 289 SER A 293 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 24  ? O VAL A 21  N ILE A 8   ? N ILE A 5   
AA1 2 3 N PHE A 11  ? N PHE A 8   O PHE A 58  ? O PHE A 55  
AA1 3 4 O TYR A 59  ? O TYR A 56  N TYR A 38  ? N TYR A 35  
AA1 4 5 N LEU A 39  ? N LEU A 36  O ALA A 42  ? O ALA A 39  
AA2 1 2 N VAL A 101 ? N VAL A 98  O LEU A 104 ? O LEU A 101 
AA3 1 2 O GLY A 196 ? O GLY A 193 N CYS A 192 ? N CYS A 189 
AA3 2 3 N VAL A 187 ? N VAL A 184 O VAL A 238 ? O VAL A 235 
AA3 3 4 O ALA A 233 ? O ALA A 230 N ILE A 225 ? N ILE A 222 
AA4 1 2 O GLY A 196 ? O GLY A 193 N CYS A 192 ? N CYS A 189 
AA4 2 3 N VAL A 187 ? N VAL A 184 O VAL A 238 ? O VAL A 235 
AA4 3 4 N GLN A 240 ? N GLN A 237 O TYR A 313 ? O TYR A 310 
AA5 1 2 N TYR A 210 ? N TYR A 207 O SER A 248 ? O SER A 245 
AA5 2 3 N LEU A 256 ? N LEU A 253 O TYR A 299 ? O TYR A 296 
AA5 3 4 O PHE A 307 ? O PHE A 304 N CYS A 263 ? N CYS A 260 
AA5 4 5 N THR A 268 ? N THR A 265 O HIS A 275 ? O HIS A 272 
AA5 5 6 N THR A 280 ? N THR A 277 O TYR A 286 ? O TYR A 283 
AA5 6 7 N CYS A 287 ? N CYS A 284 O THR A 294 ? O THR A 291 
# 
_pdbx_entry_details.entry_id                   9VAO 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_1              162 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_2              162 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_3              162 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                129.82 
_pdbx_validate_rmsd_angle.angle_target_value         115.30 
_pdbx_validate_rmsd_angle.angle_deviation            14.52 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.30 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ILE A 14  ? ? -123.05 -60.46  
2 1 PRO A 59  ? ? -68.37  98.34   
3 1 SER A 103 ? ? -113.56 -164.82 
4 1 LYS A 279 ? ? -117.47 -126.92 
5 1 ASN A 308 ? ? -141.39 -67.73  
6 1 ASN A 308 ? ? -140.32 -69.66  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+2/3   
3 -x+y,-x,z+1/3  
4 x-y,-y,-z+1/3  
5 -x,-x+y,-z+2/3 
6 y,x,-z         
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
GOL C1   C  N N 137 
GOL O1   O  N N 138 
GOL C2   C  N N 139 
GOL O2   O  N N 140 
GOL C3   C  N N 141 
GOL O3   O  N N 142 
GOL H11  H  N N 143 
GOL H12  H  N N 144 
GOL HO1  H  N N 145 
GOL H2   H  N N 146 
GOL HO2  H  N N 147 
GOL H31  H  N N 148 
GOL H32  H  N N 149 
GOL HO3  H  N N 150 
HIS N    N  N N 151 
HIS CA   C  N S 152 
HIS C    C  N N 153 
HIS O    O  N N 154 
HIS CB   C  N N 155 
HIS CG   C  Y N 156 
HIS ND1  N  Y N 157 
HIS CD2  C  Y N 158 
HIS CE1  C  Y N 159 
HIS NE2  N  Y N 160 
HIS OXT  O  N N 161 
HIS H    H  N N 162 
HIS H2   H  N N 163 
HIS HA   H  N N 164 
HIS HB2  H  N N 165 
HIS HB3  H  N N 166 
HIS HD1  H  N N 167 
HIS HD2  H  N N 168 
HIS HE1  H  N N 169 
HIS HE2  H  N N 170 
HIS HXT  H  N N 171 
HOH O    O  N N 172 
HOH H1   H  N N 173 
HOH H2   H  N N 174 
ILE N    N  N N 175 
ILE CA   C  N S 176 
ILE C    C  N N 177 
ILE O    O  N N 178 
ILE CB   C  N S 179 
ILE CG1  C  N N 180 
ILE CG2  C  N N 181 
ILE CD1  C  N N 182 
ILE OXT  O  N N 183 
ILE H    H  N N 184 
ILE H2   H  N N 185 
ILE HA   H  N N 186 
ILE HB   H  N N 187 
ILE HG12 H  N N 188 
ILE HG13 H  N N 189 
ILE HG21 H  N N 190 
ILE HG22 H  N N 191 
ILE HG23 H  N N 192 
ILE HD11 H  N N 193 
ILE HD12 H  N N 194 
ILE HD13 H  N N 195 
ILE HXT  H  N N 196 
LEU N    N  N N 197 
LEU CA   C  N S 198 
LEU C    C  N N 199 
LEU O    O  N N 200 
LEU CB   C  N N 201 
LEU CG   C  N N 202 
LEU CD1  C  N N 203 
LEU CD2  C  N N 204 
LEU OXT  O  N N 205 
LEU H    H  N N 206 
LEU H2   H  N N 207 
LEU HA   H  N N 208 
LEU HB2  H  N N 209 
LEU HB3  H  N N 210 
LEU HG   H  N N 211 
LEU HD11 H  N N 212 
LEU HD12 H  N N 213 
LEU HD13 H  N N 214 
LEU HD21 H  N N 215 
LEU HD22 H  N N 216 
LEU HD23 H  N N 217 
LEU HXT  H  N N 218 
LYS N    N  N N 219 
LYS CA   C  N S 220 
LYS C    C  N N 221 
LYS O    O  N N 222 
LYS CB   C  N N 223 
LYS CG   C  N N 224 
LYS CD   C  N N 225 
LYS CE   C  N N 226 
LYS NZ   N  N N 227 
LYS OXT  O  N N 228 
LYS H    H  N N 229 
LYS H2   H  N N 230 
LYS HA   H  N N 231 
LYS HB2  H  N N 232 
LYS HB3  H  N N 233 
LYS HG2  H  N N 234 
LYS HG3  H  N N 235 
LYS HD2  H  N N 236 
LYS HD3  H  N N 237 
LYS HE2  H  N N 238 
LYS HE3  H  N N 239 
LYS HZ1  H  N N 240 
LYS HZ2  H  N N 241 
LYS HZ3  H  N N 242 
LYS HXT  H  N N 243 
MET N    N  N N 244 
MET CA   C  N S 245 
MET C    C  N N 246 
MET O    O  N N 247 
MET CB   C  N N 248 
MET CG   C  N N 249 
MET SD   S  N N 250 
MET CE   C  N N 251 
MET OXT  O  N N 252 
MET H    H  N N 253 
MET H2   H  N N 254 
MET HA   H  N N 255 
MET HB2  H  N N 256 
MET HB3  H  N N 257 
MET HG2  H  N N 258 
MET HG3  H  N N 259 
MET HE1  H  N N 260 
MET HE2  H  N N 261 
MET HE3  H  N N 262 
MET HXT  H  N N 263 
PHE N    N  N N 264 
PHE CA   C  N S 265 
PHE C    C  N N 266 
PHE O    O  N N 267 
PHE CB   C  N N 268 
PHE CG   C  Y N 269 
PHE CD1  C  Y N 270 
PHE CD2  C  Y N 271 
PHE CE1  C  Y N 272 
PHE CE2  C  Y N 273 
PHE CZ   C  Y N 274 
PHE OXT  O  N N 275 
PHE H    H  N N 276 
PHE H2   H  N N 277 
PHE HA   H  N N 278 
PHE HB2  H  N N 279 
PHE HB3  H  N N 280 
PHE HD1  H  N N 281 
PHE HD2  H  N N 282 
PHE HE1  H  N N 283 
PHE HE2  H  N N 284 
PHE HZ   H  N N 285 
PHE HXT  H  N N 286 
PO4 P    P  N N 287 
PO4 O1   O  N N 288 
PO4 O2   O  N N 289 
PO4 O3   O  N N 290 
PO4 O4   O  N N 291 
PRO N    N  N N 292 
PRO CA   C  N S 293 
PRO C    C  N N 294 
PRO O    O  N N 295 
PRO CB   C  N N 296 
PRO CG   C  N N 297 
PRO CD   C  N N 298 
PRO OXT  O  N N 299 
PRO H    H  N N 300 
PRO HA   H  N N 301 
PRO HB2  H  N N 302 
PRO HB3  H  N N 303 
PRO HG2  H  N N 304 
PRO HG3  H  N N 305 
PRO HD2  H  N N 306 
PRO HD3  H  N N 307 
PRO HXT  H  N N 308 
SER N    N  N N 309 
SER CA   C  N S 310 
SER C    C  N N 311 
SER O    O  N N 312 
SER CB   C  N N 313 
SER OG   O  N N 314 
SER OXT  O  N N 315 
SER H    H  N N 316 
SER H2   H  N N 317 
SER HA   H  N N 318 
SER HB2  H  N N 319 
SER HB3  H  N N 320 
SER HG   H  N N 321 
SER HXT  H  N N 322 
THR N    N  N N 323 
THR CA   C  N S 324 
THR C    C  N N 325 
THR O    O  N N 326 
THR CB   C  N R 327 
THR OG1  O  N N 328 
THR CG2  C  N N 329 
THR OXT  O  N N 330 
THR H    H  N N 331 
THR H2   H  N N 332 
THR HA   H  N N 333 
THR HB   H  N N 334 
THR HG1  H  N N 335 
THR HG21 H  N N 336 
THR HG22 H  N N 337 
THR HG23 H  N N 338 
THR HXT  H  N N 339 
TRP N    N  N N 340 
TRP CA   C  N S 341 
TRP C    C  N N 342 
TRP O    O  N N 343 
TRP CB   C  N N 344 
TRP CG   C  Y N 345 
TRP CD1  C  Y N 346 
TRP CD2  C  Y N 347 
TRP NE1  N  Y N 348 
TRP CE2  C  Y N 349 
TRP CE3  C  Y N 350 
TRP CZ2  C  Y N 351 
TRP CZ3  C  Y N 352 
TRP CH2  C  Y N 353 
TRP OXT  O  N N 354 
TRP H    H  N N 355 
TRP H2   H  N N 356 
TRP HA   H  N N 357 
TRP HB2  H  N N 358 
TRP HB3  H  N N 359 
TRP HD1  H  N N 360 
TRP HE1  H  N N 361 
TRP HE3  H  N N 362 
TRP HZ2  H  N N 363 
TRP HZ3  H  N N 364 
TRP HH2  H  N N 365 
TRP HXT  H  N N 366 
TYR N    N  N N 367 
TYR CA   C  N S 368 
TYR C    C  N N 369 
TYR O    O  N N 370 
TYR CB   C  N N 371 
TYR CG   C  Y N 372 
TYR CD1  C  Y N 373 
TYR CD2  C  Y N 374 
TYR CE1  C  Y N 375 
TYR CE2  C  Y N 376 
TYR CZ   C  Y N 377 
TYR OH   O  N N 378 
TYR OXT  O  N N 379 
TYR H    H  N N 380 
TYR H2   H  N N 381 
TYR HA   H  N N 382 
TYR HB2  H  N N 383 
TYR HB3  H  N N 384 
TYR HD1  H  N N 385 
TYR HD2  H  N N 386 
TYR HE1  H  N N 387 
TYR HE2  H  N N 388 
TYR HH   H  N N 389 
TYR HXT  H  N N 390 
VAL N    N  N N 391 
VAL CA   C  N S 392 
VAL C    C  N N 393 
VAL O    O  N N 394 
VAL CB   C  N N 395 
VAL CG1  C  N N 396 
VAL CG2  C  N N 397 
VAL OXT  O  N N 398 
VAL H    H  N N 399 
VAL H2   H  N N 400 
VAL HA   H  N N 401 
VAL HB   H  N N 402 
VAL HG11 H  N N 403 
VAL HG12 H  N N 404 
VAL HG13 H  N N 405 
VAL HG21 H  N N 406 
VAL HG22 H  N N 407 
VAL HG23 H  N N 408 
VAL HXT  H  N N 409 
ZN  ZN   ZN N N 410 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PO4 P   O1   doub N N 273 
PO4 P   O2   sing N N 274 
PO4 P   O3   sing N N 275 
PO4 P   O4   sing N N 276 
PRO N   CA   sing N N 277 
PRO N   CD   sing N N 278 
PRO N   H    sing N N 279 
PRO CA  C    sing N N 280 
PRO CA  CB   sing N N 281 
PRO CA  HA   sing N N 282 
PRO C   O    doub N N 283 
PRO C   OXT  sing N N 284 
PRO CB  CG   sing N N 285 
PRO CB  HB2  sing N N 286 
PRO CB  HB3  sing N N 287 
PRO CG  CD   sing N N 288 
PRO CG  HG2  sing N N 289 
PRO CG  HG3  sing N N 290 
PRO CD  HD2  sing N N 291 
PRO CD  HD3  sing N N 292 
PRO OXT HXT  sing N N 293 
SER N   CA   sing N N 294 
SER N   H    sing N N 295 
SER N   H2   sing N N 296 
SER CA  C    sing N N 297 
SER CA  CB   sing N N 298 
SER CA  HA   sing N N 299 
SER C   O    doub N N 300 
SER C   OXT  sing N N 301 
SER CB  OG   sing N N 302 
SER CB  HB2  sing N N 303 
SER CB  HB3  sing N N 304 
SER OG  HG   sing N N 305 
SER OXT HXT  sing N N 306 
THR N   CA   sing N N 307 
THR N   H    sing N N 308 
THR N   H2   sing N N 309 
THR CA  C    sing N N 310 
THR CA  CB   sing N N 311 
THR CA  HA   sing N N 312 
THR C   O    doub N N 313 
THR C   OXT  sing N N 314 
THR CB  OG1  sing N N 315 
THR CB  CG2  sing N N 316 
THR CB  HB   sing N N 317 
THR OG1 HG1  sing N N 318 
THR CG2 HG21 sing N N 319 
THR CG2 HG22 sing N N 320 
THR CG2 HG23 sing N N 321 
THR OXT HXT  sing N N 322 
TRP N   CA   sing N N 323 
TRP N   H    sing N N 324 
TRP N   H2   sing N N 325 
TRP CA  C    sing N N 326 
TRP CA  CB   sing N N 327 
TRP CA  HA   sing N N 328 
TRP C   O    doub N N 329 
TRP C   OXT  sing N N 330 
TRP CB  CG   sing N N 331 
TRP CB  HB2  sing N N 332 
TRP CB  HB3  sing N N 333 
TRP CG  CD1  doub Y N 334 
TRP CG  CD2  sing Y N 335 
TRP CD1 NE1  sing Y N 336 
TRP CD1 HD1  sing N N 337 
TRP CD2 CE2  doub Y N 338 
TRP CD2 CE3  sing Y N 339 
TRP NE1 CE2  sing Y N 340 
TRP NE1 HE1  sing N N 341 
TRP CE2 CZ2  sing Y N 342 
TRP CE3 CZ3  doub Y N 343 
TRP CE3 HE3  sing N N 344 
TRP CZ2 CH2  doub Y N 345 
TRP CZ2 HZ2  sing N N 346 
TRP CZ3 CH2  sing Y N 347 
TRP CZ3 HZ3  sing N N 348 
TRP CH2 HH2  sing N N 349 
TRP OXT HXT  sing N N 350 
TYR N   CA   sing N N 351 
TYR N   H    sing N N 352 
TYR N   H2   sing N N 353 
TYR CA  C    sing N N 354 
TYR CA  CB   sing N N 355 
TYR CA  HA   sing N N 356 
TYR C   O    doub N N 357 
TYR C   OXT  sing N N 358 
TYR CB  CG   sing N N 359 
TYR CB  HB2  sing N N 360 
TYR CB  HB3  sing N N 361 
TYR CG  CD1  doub Y N 362 
TYR CG  CD2  sing Y N 363 
TYR CD1 CE1  sing Y N 364 
TYR CD1 HD1  sing N N 365 
TYR CD2 CE2  doub Y N 366 
TYR CD2 HD2  sing N N 367 
TYR CE1 CZ   doub Y N 368 
TYR CE1 HE1  sing N N 369 
TYR CE2 CZ   sing Y N 370 
TYR CE2 HE2  sing N N 371 
TYR CZ  OH   sing N N 372 
TYR OH  HH   sing N N 373 
TYR OXT HXT  sing N N 374 
VAL N   CA   sing N N 375 
VAL N   H    sing N N 376 
VAL N   H2   sing N N 377 
VAL CA  C    sing N N 378 
VAL CA  CB   sing N N 379 
VAL CA  HA   sing N N 380 
VAL C   O    doub N N 381 
VAL C   OXT  sing N N 382 
VAL CB  CG1  sing N N 383 
VAL CB  CG2  sing N N 384 
VAL CB  HB   sing N N 385 
VAL CG1 HG11 sing N N 386 
VAL CG1 HG12 sing N N 387 
VAL CG1 HG13 sing N N 388 
VAL CG2 HG21 sing N N 389 
VAL CG2 HG22 sing N N 390 
VAL CG2 HG23 sing N N 391 
VAL OXT HXT  sing N N 392 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                India 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6wrh 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 32 2 1' 
_space_group.name_Hall        
;P 32 2"
;
_space_group.IT_number        154 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9VAO 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012222 
_atom_sites.fract_transf_matrix[1][2]   0.007056 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014113 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007478 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? ?        ?       ? ? ?        ?        ? ? ?   ? ? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P  ? ? 9.51135  5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 1   ? -75.51193 22.03305  -8.82161  1.000 49.46356 ? -2  SER A N   1 
ATOM   2    C  CA  . SER A 1 1   ? -74.98808 20.73965  -8.38864  1.000 56.24837 ? -2  SER A CA  1 
ATOM   3    C  C   . SER A 1 1   ? -73.59821 20.87724  -7.75047  1.000 53.31316 ? -2  SER A C   1 
ATOM   4    O  O   . SER A 1 1   ? -73.46478 20.80757  -6.52137  1.000 57.26289 ? -2  SER A O   1 
ATOM   5    C  CB  . SER A 1 1   ? -74.93384 19.75865  -9.56205  1.000 54.65021 ? -2  SER A CB  1 
ATOM   6    O  OG  . SER A 1 1   ? -75.04825 18.41979  -9.10662  1.000 58.57117 ? -2  SER A OG  1 
ATOM   7    N  N   A HIS A 1 2   ? -72.56828 21.08339  -8.57129  0.572 48.88575 ? -1  HIS A N   1 
ATOM   8    N  N   B HIS A 1 2   ? -72.57801 21.07681  -8.58248  0.428 48.88627 ? -1  HIS A N   1 
ATOM   9    C  CA  A HIS A 1 2   ? -71.19809 21.08989  -8.06953  0.572 48.76050 ? -1  HIS A CA  1 
ATOM   10   C  CA  B HIS A 1 2   ? -71.21006 21.13667  -8.08889  0.428 48.74403 ? -1  HIS A CA  1 
ATOM   11   C  C   A HIS A 1 2   ? -70.83065 22.44906  -7.47746  0.572 45.96745 ? -1  HIS A C   1 
ATOM   12   C  C   B HIS A 1 2   ? -70.94252 22.47557  -7.41096  0.428 45.92275 ? -1  HIS A C   1 
ATOM   13   O  O   A HIS A 1 2   ? -71.08044 23.49831  -8.08233  0.572 44.07360 ? -1  HIS A O   1 
ATOM   14   O  O   B HIS A 1 2   ? -71.38581 23.53173  -7.87482  0.428 43.57181 ? -1  HIS A O   1 
ATOM   15   C  CB  A HIS A 1 2   ? -70.21850 20.70097  -9.17827  0.572 48.79406 ? -1  HIS A CB  1 
ATOM   16   C  CB  B HIS A 1 2   ? -70.21145 20.89933  -9.22704  0.428 48.59270 ? -1  HIS A CB  1 
ATOM   17   C  CG  A HIS A 1 2   ? -70.02448 19.22045  -9.31388  0.572 51.33587 ? -1  HIS A CG  1 
ATOM   18   C  CG  B HIS A 1 2   ? -69.77101 22.14585  -9.92886  0.428 43.75184 ? -1  HIS A CG  1 
ATOM   19   N  ND1 A HIS A 1 2   ? -70.68351 18.30825  -8.51559  0.572 51.23984 ? -1  HIS A ND1 1 
ATOM   20   N  ND1 B HIS A 1 2   ? -70.53760 22.77247  -10.88767 0.428 45.32598 ? -1  HIS A ND1 1 
ATOM   21   C  CD2 A HIS A 1 2   ? -69.24301 18.49405  -10.14831 0.572 51.04170 ? -1  HIS A CD2 1 
ATOM   22   C  CD2 B HIS A 1 2   ? -68.63357 22.87287  -9.82214  0.428 43.69159 ? -1  HIS A CD2 1 
ATOM   23   C  CE1 A HIS A 1 2   ? -70.31949 17.08466  -8.85503  0.572 54.75464 ? -1  HIS A CE1 1 
ATOM   24   C  CE1 B HIS A 1 2   ? -69.89560 23.83636  -11.33612 0.428 46.12457 ? -1  HIS A CE1 1 
ATOM   25   N  NE2 A HIS A 1 2   ? -69.44546 17.16935  -9.84248  0.572 59.52599 ? -1  HIS A NE2 1 
ATOM   26   N  NE2 B HIS A 1 2   ? -68.73748 23.92045  -10.70486 0.428 44.16144 ? -1  HIS A NE2 1 
ATOM   27   N  N   . MET A 1 3   ? -70.23950 22.41901  -6.28598  1.000 42.95785 ? 0   MET A N   1 
ATOM   28   C  CA  . MET A 1 3   ? -69.81728 23.62538  -5.60031  1.000 34.90149 ? 0   MET A CA  1 
ATOM   29   C  C   . MET A 1 3   ? -68.49366 24.12581  -6.17270  1.000 37.62264 ? 0   MET A C   1 
ATOM   30   O  O   . MET A 1 3   ? -67.59380 23.33540  -6.47043  1.000 38.16640 ? 0   MET A O   1 
ATOM   31   C  CB  . MET A 1 3   ? -69.68063 23.33779  -4.11421  1.000 34.29428 ? 0   MET A CB  1 
ATOM   32   C  CG  . MET A 1 3   ? -69.42471 24.55425  -3.27787  1.000 36.48206 ? 0   MET A CG  1 
ATOM   33   S  SD  . MET A 1 3   ? -69.21859 24.01620  -1.58082  1.000 43.12396 ? 0   MET A SD  1 
ATOM   34   C  CE  . MET A 1 3   ? -67.68440 23.11318  -1.81904  1.000 41.57958 ? 0   MET A CE  1 
ATOM   35   N  N   . GLU A 1 4   ? -68.38596 25.44433  -6.34369  1.000 32.57596 ? 1   GLU A N   1 
ATOM   36   C  CA  . GLU A 1 4   ? -67.15285 26.03914  -6.84371  1.000 26.15532 ? 1   GLU A CA  1 
ATOM   37   C  C   . GLU A 1 4   ? -65.98071 25.64467  -5.94505  1.000 27.98573 ? 1   GLU A C   1 
ATOM   38   O  O   . GLU A 1 4   ? -66.08268 25.66749  -4.72001  1.000 27.76671 ? 1   GLU A O   1 
ATOM   39   C  CB  . GLU A 1 4   ? -67.29405 27.55988  -6.89480  1.000 30.81072 ? 1   GLU A CB  1 
ATOM   40   C  CG  . GLU A 1 4   ? -66.05094 28.30169  -7.33467  1.000 28.95760 ? 1   GLU A CG  1 
ATOM   41   C  CD  . GLU A 1 4   ? -66.30064 29.78980  -7.52283  1.000 35.44212 ? 1   GLU A CD  1 
ATOM   42   O  OE1 . GLU A 1 4   ? -66.62629 30.47056  -6.52576  1.000 34.57832 ? 1   GLU A OE1 1 
ATOM   43   O  OE2 . GLU A 1 4   ? -66.18674 30.27067  -8.66910  1.000 36.65715 ? 1   GLU A OE2 1 
ATOM   44   N  N   . VAL A 1 5   ? -64.86146 25.29107  -6.55490  1.000 28.84678 ? 2   VAL A N   1 
ATOM   45   C  CA  . VAL A 1 5   ? -63.74733 24.73218  -5.79862  1.000 34.69594 ? 2   VAL A CA  1 
ATOM   46   C  C   . VAL A 1 5   ? -63.04283 25.85059  -5.04655  1.000 32.93853 ? 2   VAL A C   1 
ATOM   47   O  O   . VAL A 1 5   ? -62.73225 26.90259  -5.61469  1.000 37.71968 ? 2   VAL A O   1 
ATOM   48   C  CB  . VAL A 1 5   ? -62.77434 23.98663  -6.72747  1.000 33.94418 ? 2   VAL A CB  1 
ATOM   49   C  CG1 . VAL A 1 5   ? -61.50260 23.61434  -5.97732  1.000 29.18893 ? 2   VAL A CG1 1 
ATOM   50   C  CG2 . VAL A 1 5   ? -63.44991 22.74669  -7.29129  1.000 33.40580 ? 2   VAL A CG2 1 
ATOM   51   N  N   A ARG A 1 6   ? -62.82585 25.65835  -3.75796  0.607 32.20523 ? 3   ARG A N   1 
ATOM   52   N  N   B ARG A 1 6   ? -62.77951 25.61336  -3.76415  0.393 32.20078 ? 3   ARG A N   1 
ATOM   53   C  CA  A ARG A 1 6   ? -61.96449 26.56951  -3.02625  0.607 32.62351 ? 3   ARG A CA  1 
ATOM   54   C  CA  B ARG A 1 6   ? -62.02996 26.52454  -2.91040  0.393 32.54488 ? 3   ARG A CA  1 
ATOM   55   C  C   A ARG A 1 6   ? -60.78395 25.78116  -2.48102  0.607 30.41952 ? 3   ARG A C   1 
ATOM   56   C  C   B ARG A 1 6   ? -60.79903 25.79072  -2.38380  0.393 30.41253 ? 3   ARG A C   1 
ATOM   57   O  O   A ARG A 1 6   ? -60.91798 24.61457  -2.09899  0.607 26.38648 ? 3   ARG A O   1 
ATOM   58   O  O   B ARG A 1 6   ? -60.91251 24.65909  -1.90143  0.393 26.89265 ? 3   ARG A O   1 
ATOM   59   C  CB  A ARG A 1 6   ? -62.70371 27.30733  -1.90749  0.607 33.55693 ? 3   ARG A CB  1 
ATOM   60   C  CB  B ARG A 1 6   ? -62.91967 27.03791  -1.76531  0.393 33.79329 ? 3   ARG A CB  1 
ATOM   61   C  CG  A ARG A 1 6   ? -61.76872 28.14463  -1.04004  0.607 36.51161 ? 3   ARG A CG  1 
ATOM   62   C  CG  B ARG A 1 6   ? -63.85085 25.97786  -1.14570  0.393 34.35871 ? 3   ARG A CG  1 
ATOM   63   C  CD  A ARG A 1 6   ? -62.15736 29.59986  -0.93859  0.607 41.36591 ? 3   ARG A CD  1 
ATOM   64   C  CD  B ARG A 1 6   ? -65.31426 26.43728  -1.05936  0.393 33.87934 ? 3   ARG A CD  1 
ATOM   65   N  NE  A ARG A 1 6   ? -63.44039 29.79107  -0.28084  0.607 36.75369 ? 3   ARG A NE  1 
ATOM   66   N  NE  B ARG A 1 6   ? -65.76726 26.67644  0.30945   0.393 33.69399 ? 3   ARG A NE  1 
ATOM   67   C  CZ  A ARG A 1 6   ? -63.61850 29.88359  1.03087   0.607 36.87431 ? 3   ARG A CZ  1 
ATOM   68   C  CZ  B ARG A 1 6   ? -67.03254 26.88167  0.66468   0.393 34.39707 ? 3   ARG A CZ  1 
ATOM   69   N  NH1 A ARG A 1 6   ? -62.61132 29.76350  1.87840   0.607 36.40034 ? 3   ARG A NH1 1 
ATOM   70   N  NH1 B ARG A 1 6   ? -68.01605 26.85797  -0.22070  0.393 32.43659 ? 3   ARG A NH1 1 
ATOM   71   N  NH2 A ARG A 1 6   ? -64.84074 30.11625  1.50326   0.607 37.23093 ? 3   ARG A NH2 1 
ATOM   72   N  NH2 B ARG A 1 6   ? -67.32065 27.10746  1.94420   0.393 33.45691 ? 3   ARG A NH2 1 
ATOM   73   N  N   . THR A 1 7   ? -59.62053 26.40959  -2.51213  1.000 31.76751 ? 4   THR A N   1 
ATOM   74   C  CA  . THR A 1 7   ? -58.38724 25.81023  -2.02131  1.000 28.89993 ? 4   THR A CA  1 
ATOM   75   C  C   . THR A 1 7   ? -57.65806 26.79801  -1.12901  1.000 30.44510 ? 4   THR A C   1 
ATOM   76   O  O   . THR A 1 7   ? -57.86312 28.01175  -1.21653  1.000 30.42751 ? 4   THR A O   1 
ATOM   77   C  CB  . THR A 1 7   ? -57.44777 25.41543  -3.14578  1.000 28.14703 ? 4   THR A CB  1 
ATOM   78   O  OG1 . THR A 1 7   ? -57.02063 26.60408  -3.80745  1.000 33.13975 ? 4   THR A OG1 1 
ATOM   79   C  CG2 . THR A 1 7   ? -58.12030 24.48484  -4.11957  1.000 30.16844 ? 4   THR A CG2 1 
ATOM   80   N  N   . ILE A 1 8   ? -56.79564 26.25676  -0.26391  1.000 25.74278 ? 5   ILE A N   1 
ATOM   81   C  CA  . ILE A 1 8   ? -55.81522 27.03832  0.47935   1.000 23.89384 ? 5   ILE A CA  1 
ATOM   82   C  C   . ILE A 1 8   ? -54.47272 26.33470  0.33662   1.000 24.29391 ? 5   ILE A C   1 
ATOM   83   O  O   . ILE A 1 8   ? -54.40321 25.12980  0.08180   1.000 22.59924 ? 5   ILE A O   1 
ATOM   84   C  CB  . ILE A 1 8   ? -56.14869 27.21132  1.98516   1.000 26.23984 ? 5   ILE A CB  1 
ATOM   85   C  CG1 . ILE A 1 8   ? -56.30816 25.85083  2.66604   1.000 21.77331 ? 5   ILE A CG1 1 
ATOM   86   C  CG2 . ILE A 1 8   ? -57.36867 28.10656  2.21396   1.000 28.00596 ? 5   ILE A CG2 1 
ATOM   87   C  CD1 . ILE A 1 8   ? -56.47876 25.92408  4.16429   1.000 30.45808 ? 5   ILE A CD1 1 
ATOM   88   N  N   . LYS A 1 9   ? -53.40474 27.10570  0.51191   1.000 23.54081 ? 6   LYS A N   1 
ATOM   89   C  CA  . LYS A 1 9   ? -52.05429 26.55592  0.60668   1.000 23.21771 ? 6   LYS A CA  1 
ATOM   90   C  C   . LYS A 1 9   ? -51.78212 26.18303  2.05414   1.000 24.42797 ? 6   LYS A C   1 
ATOM   91   O  O   . LYS A 1 9   ? -52.05870 26.97102  2.96719   1.000 23.90348 ? 6   LYS A O   1 
ATOM   92   C  CB  . LYS A 1 9   ? -51.01016 27.57099  0.12464   1.000 24.16168 ? 6   LYS A CB  1 
ATOM   93   C  CG  . LYS A 1 9   ? -49.54922 27.14869  0.39262   1.000 24.08810 ? 6   LYS A CG  1 
ATOM   94   C  CD  . LYS A 1 9   ? -48.56144 28.28354  0.12209   1.000 21.88655 ? 6   LYS A CD  1 
ATOM   95   C  CE  . LYS A 1 9   ? -48.62708 29.36752  1.18092   1.000 24.02662 ? 6   LYS A CE  1 
ATOM   96   N  NZ  . LYS A 1 9   ? -47.75428 30.52173  0.84987   1.000 28.53579 ? 6   LYS A NZ  1 
ATOM   97   N  N   . VAL A 1 10  ? -51.24049 24.98392  2.27141   1.000 23.63885 ? 7   VAL A N   1 
ATOM   98   C  CA  . VAL A 1 10  ? -50.75517 24.57311  3.58507   1.000 21.92706 ? 7   VAL A CA  1 
ATOM   99   C  C   . VAL A 1 10  ? -49.40451 23.90050  3.37458   1.000 18.60693 ? 7   VAL A C   1 
ATOM   100  O  O   . VAL A 1 10  ? -49.01382 23.59198  2.24994   1.000 24.07607 ? 7   VAL A O   1 
ATOM   101  C  CB  . VAL A 1 10  ? -51.72724 23.62606  4.34309   1.000 22.47152 ? 7   VAL A CB  1 
ATOM   102  C  CG1 . VAL A 1 10  ? -53.13262 24.27207  4.53371   1.000 22.08566 ? 7   VAL A CG1 1 
ATOM   103  C  CG2 . VAL A 1 10  ? -51.83660 22.33048  3.64939   1.000 20.03089 ? 7   VAL A CG2 1 
ATOM   104  N  N   . PHE A 1 11  ? -48.68657 23.67188  4.47564   1.000 21.75681 ? 8   PHE A N   1 
ATOM   105  C  CA  . PHE A 1 11  ? -47.43373 22.93412  4.42061   1.000 16.29809 ? 8   PHE A CA  1 
ATOM   106  C  C   . PHE A 1 11  ? -47.55932 21.64601  5.22132   1.000 19.14760 ? 8   PHE A C   1 
ATOM   107  O  O   . PHE A 1 11  ? -48.17010 21.62700  6.29153   1.000 18.58966 ? 8   PHE A O   1 
ATOM   108  C  CB  . PHE A 1 11  ? -46.28539 23.78381  4.95430   1.000 15.46345 ? 8   PHE A CB  1 
ATOM   109  C  CG  . PHE A 1 11  ? -46.10415 25.06476  4.18994   1.000 16.53590 ? 8   PHE A CG  1 
ATOM   110  C  CD1 . PHE A 1 11  ? -45.49676 25.06250  2.94107   1.000 19.99804 ? 8   PHE A CD1 1 
ATOM   111  C  CD2 . PHE A 1 11  ? -46.58492 26.25666  4.69796   1.000 19.59026 ? 8   PHE A CD2 1 
ATOM   112  C  CE1 . PHE A 1 11  ? -45.34523 26.25641  2.20667   1.000 19.88974 ? 8   PHE A CE1 1 
ATOM   113  C  CE2 . PHE A 1 11  ? -46.43726 27.44598  3.97736   1.000 23.05601 ? 8   PHE A CE2 1 
ATOM   114  C  CZ  . PHE A 1 11  ? -45.81365 27.43548  2.73214   1.000 19.76119 ? 8   PHE A CZ  1 
ATOM   115  N  N   . THR A 1 12  ? -47.00936 20.56494  4.68868   1.000 19.06028 ? 9   THR A N   1 
ATOM   116  C  CA  . THR A 1 12  ? -46.91092 19.33254  5.45649   1.000 18.46907 ? 9   THR A CA  1 
ATOM   117  C  C   . THR A 1 12  ? -45.46360 19.10020  5.85110   1.000 18.49394 ? 9   THR A C   1 
ATOM   118  O  O   . THR A 1 12  ? -44.53423 19.65315  5.25724   1.000 17.71137 ? 9   THR A O   1 
ATOM   119  C  CB  . THR A 1 12  ? -47.42847 18.13032  4.67004   1.000 20.72488 ? 9   THR A CB  1 
ATOM   120  O  OG1 . THR A 1 12  ? -46.72619 18.06670  3.42809   1.000 19.66805 ? 9   THR A OG1 1 
ATOM   121  C  CG2 . THR A 1 12  ? -48.95469 18.24760  4.43959   1.000 21.87511 ? 9   THR A CG2 1 
ATOM   122  N  N   . THR A 1 13  ? -45.28805 18.26958  6.86715   1.000 15.66635 ? 10  THR A N   1 
ATOM   123  C  CA  . THR A 1 13  ? -43.96655 18.06297  7.43447   1.000 18.42957 ? 10  THR A CA  1 
ATOM   124  C  C   . THR A 1 13  ? -43.98511 16.74692  8.19545   1.000 17.80195 ? 10  THR A C   1 
ATOM   125  O  O   . THR A 1 13  ? -45.04830 16.22252  8.54405   1.000 19.22518 ? 10  THR A O   1 
ATOM   126  C  CB  . THR A 1 13  ? -43.59293 19.22694  8.35040   1.000 15.37269 ? 10  THR A CB  1 
ATOM   127  O  OG1 . THR A 1 13  ? -42.19503 19.18599  8.62578   1.000 20.02849 ? 10  THR A OG1 1 
ATOM   128  C  CG2 . THR A 1 13  ? -44.38055 19.14842  9.67034   1.000 17.85181 ? 10  THR A CG2 1 
ATOM   129  N  N   . VAL A 1 14  ? -42.79926 16.20606  8.43881   1.000 19.19167 ? 11  VAL A N   1 
ATOM   130  C  CA  . VAL A 1 14  ? -42.62980 15.20122  9.47982   1.000 19.43667 ? 11  VAL A CA  1 
ATOM   131  C  C   . VAL A 1 14  ? -41.66675 15.65140  10.56029  1.000 20.99004 ? 11  VAL A C   1 
ATOM   132  O  O   . VAL A 1 14  ? -41.63739 15.03062  11.63124  1.000 20.40549 ? 11  VAL A O   1 
ATOM   133  C  CB  . VAL A 1 14  ? -42.17549 13.84006  8.90751   1.000 16.65008 ? 11  VAL A CB  1 
ATOM   134  C  CG1 . VAL A 1 14  ? -43.25908 13.26056  7.97537   1.000 19.55939 ? 11  VAL A CG1 1 
ATOM   135  C  CG2 . VAL A 1 14  ? -40.84222 13.99069  8.19193   1.000 18.85975 ? 11  VAL A CG2 1 
ATOM   136  N  N   . ASP A 1 15  ? -40.90319 16.72837  10.34435  1.000 20.71110 ? 12  ASP A N   1 
ATOM   137  C  CA  . ASP A 1 15  ? -39.96499 17.17762  11.35743  1.000 17.74473 ? 12  ASP A CA  1 
ATOM   138  C  C   . ASP A 1 15  ? -40.17842 18.61367  11.81904  1.000 24.81630 ? 12  ASP A C   1 
ATOM   139  O  O   . ASP A 1 15  ? -39.46312 19.05937  12.71934  1.000 21.60361 ? 12  ASP A O   1 
ATOM   140  C  CB  . ASP A 1 15  ? -38.52115 16.97935  10.87190  1.000 22.14570 ? 12  ASP A CB  1 
ATOM   141  C  CG  . ASP A 1 15  ? -38.19064 17.76505  9.58694   1.000 17.18010 ? 12  ASP A CG  1 
ATOM   142  O  OD1 . ASP A 1 15  ? -38.92060 18.72390  9.22104   1.000 22.06612 ? 12  ASP A OD1 1 
ATOM   143  O  OD2 . ASP A 1 15  ? -37.17171 17.40573  8.94691   1.000 21.76852 ? 12  ASP A OD2 1 
ATOM   144  N  N   . ASN A 1 16  ? -41.16383 19.32386  11.27045  1.000 19.94724 ? 13  ASN A N   1 
ATOM   145  C  CA  . ASN A 1 16  ? -41.44825 20.72783  11.57367  1.000 21.04732 ? 13  ASN A CA  1 
ATOM   146  C  C   . ASN A 1 16  ? -40.32638 21.66220  11.12595  1.000 21.38253 ? 13  ASN A C   1 
ATOM   147  O  O   . ASN A 1 16  ? -40.26289 22.81387  11.56076  1.000 21.79644 ? 13  ASN A O   1 
ATOM   148  C  CB  . ASN A 1 16  ? -41.74719 20.95448  13.05271  1.000 20.15781 ? 13  ASN A CB  1 
ATOM   149  C  CG  . ASN A 1 16  ? -42.77086 22.03389  13.25945  1.000 27.00499 ? 13  ASN A CG  1 
ATOM   150  O  OD1 . ASN A 1 16  ? -43.54331 22.32056  12.36187  1.000 24.70809 ? 13  ASN A OD1 1 
ATOM   151  N  ND2 . ASN A 1 16  ? -42.79216 22.63640  14.44798  1.000 28.80644 ? 13  ASN A ND2 1 
ATOM   152  N  N   . ILE A 1 17  ? -39.44544 21.20187  10.24867  1.000 18.78770 ? 14  ILE A N   1 
ATOM   153  C  CA  . ILE A 1 17  ? -38.36341 22.04854  9.75798   1.000 22.78691 ? 14  ILE A CA  1 
ATOM   154  C  C   . ILE A 1 17  ? -38.46552 22.10262  8.24458   1.000 23.38787 ? 14  ILE A C   1 
ATOM   155  O  O   . ILE A 1 17  ? -38.63390 23.17319  7.65577   1.000 21.94045 ? 14  ILE A O   1 
ATOM   156  C  CB  . ILE A 1 17  ? -36.98442 21.52076  10.19482  1.000 25.81573 ? 14  ILE A CB  1 
ATOM   157  C  CG1 . ILE A 1 17  ? -36.83758 21.58316  11.71552  1.000 23.82608 ? 14  ILE A CG1 1 
ATOM   158  C  CG2 . ILE A 1 17  ? -35.88399 22.26515  9.48557   1.000 22.44774 ? 14  ILE A CG2 1 
ATOM   159  C  CD1 . ILE A 1 17  ? -35.65879 20.79442  12.24112  1.000 25.64259 ? 14  ILE A CD1 1 
ATOM   160  N  N   . ASN A 1 18  ? -38.35746 20.93925  7.61376   1.000 21.30452 ? 15  ASN A N   1 
ATOM   161  C  CA  . ASN A 1 18  ? -38.54194 20.79592  6.17954   1.000 21.05048 ? 15  ASN A CA  1 
ATOM   162  C  C   . ASN A 1 18  ? -40.03079 20.84530  5.87518   1.000 22.08010 ? 15  ASN A C   1 
ATOM   163  O  O   . ASN A 1 18  ? -40.78089 19.94056  6.25465   1.000 20.98121 ? 15  ASN A O   1 
ATOM   164  C  CB  . ASN A 1 18  ? -37.90270 19.49433  5.71718   1.000 22.98061 ? 15  ASN A CB  1 
ATOM   165  C  CG  . ASN A 1 18  ? -36.39928 19.55416  5.82079   1.000 30.07288 ? 15  ASN A CG  1 
ATOM   166  O  OD1 . ASN A 1 18  ? -35.76917 20.28091  5.06419   1.000 36.14657 ? 15  ASN A OD1 1 
ATOM   167  N  ND2 . ASN A 1 18  ? -35.81613 18.83724  6.78467   1.000 30.30879 ? 15  ASN A ND2 1 
ATOM   168  N  N   . LEU A 1 19  ? -40.45889 21.92081  5.22652   1.000 19.73329 ? 16  LEU A N   1 
ATOM   169  C  CA  . LEU A 1 19  ? -41.85161 22.10871  4.85380   1.000 16.58760 ? 16  LEU A CA  1 
ATOM   170  C  C   . LEU A 1 19  ? -42.10451 21.64944  3.42143   1.000 22.55628 ? 16  LEU A C   1 
ATOM   171  O  O   . LEU A 1 19  ? -41.23049 21.73508  2.55741   1.000 24.17909 ? 16  LEU A O   1 
ATOM   172  C  CB  . LEU A 1 19  ? -42.22549 23.58023  5.00234   1.000 18.38679 ? 16  LEU A CB  1 
ATOM   173  C  CG  . LEU A 1 19  ? -41.93335 24.08946  6.42208   1.000 21.79308 ? 16  LEU A CG  1 
ATOM   174  C  CD1 . LEU A 1 19  ? -42.38504 25.52940  6.59084   1.000 21.49241 ? 16  LEU A CD1 1 
ATOM   175  C  CD2 . LEU A 1 19  ? -42.63486 23.21021  7.44165   1.000 19.43020 ? 16  LEU A CD2 1 
ATOM   176  N  N   . HIS A 1 20  ? -43.32713 21.19010  3.16100   1.000 18.58783 ? 17  HIS A N   1 
ATOM   177  C  CA  . HIS A 1 20  ? -43.69749 20.71320  1.83410   1.000 16.36702 ? 17  HIS A CA  1 
ATOM   178  C  C   . HIS A 1 20  ? -45.00313 21.37077  1.41951   1.000 15.58059 ? 17  HIS A C   1 
ATOM   179  O  O   . HIS A 1 20  ? -46.04732 21.12379  2.03477   1.000 18.06527 ? 17  HIS A O   1 
ATOM   180  C  CB  . HIS A 1 20  ? -43.82409 19.18612  1.80956   1.000 19.82112 ? 17  HIS A CB  1 
ATOM   181  C  CG  . HIS A 1 20  ? -42.58224 18.48196  2.25189   1.000 21.34391 ? 17  HIS A CG  1 
ATOM   182  N  ND1 . HIS A 1 20  ? -41.51266 18.26678  1.41182   1.000 23.28537 ? 17  HIS A ND1 1 
ATOM   183  C  CD2 . HIS A 1 20  ? -42.23835 17.93870  3.44877   1.000 20.83255 ? 17  HIS A CD2 1 
ATOM   184  C  CE1 . HIS A 1 20  ? -40.55815 17.63014  2.06890   1.000 22.29567 ? 17  HIS A CE1 1 
ATOM   185  N  NE2 . HIS A 1 20  ? -40.97038 17.42595  3.30890   1.000 21.20433 ? 17  HIS A NE2 1 
ATOM   186  N  N   . THR A 1 21  ? -44.93360 22.19336  0.37292   1.000 18.73434 ? 18  THR A N   1 
ATOM   187  C  CA  . THR A 1 21  ? -46.08163 22.97079  -0.08665  1.000 19.45457 ? 18  THR A CA  1 
ATOM   188  C  C   . THR A 1 21  ? -47.16693 22.04789  -0.60324  1.000 17.51059 ? 18  THR A C   1 
ATOM   189  O  O   . THR A 1 21  ? -46.88696 21.11373  -1.35417  1.000 21.73273 ? 18  THR A O   1 
ATOM   190  C  CB  . THR A 1 21  ? -45.65480 23.93465  -1.19844  1.000 21.43907 ? 18  THR A CB  1 
ATOM   191  O  OG1 . THR A 1 21  ? -44.46701 24.65914  -0.79869  1.000 16.81738 ? 18  THR A OG1 1 
ATOM   192  C  CG2 . THR A 1 21  ? -46.78913 24.91894  -1.51495  1.000 23.96975 ? 18  THR A CG2 1 
ATOM   193  N  N   . GLN A 1 22  ? -48.40645 22.31586  -0.20033  1.000 18.71040 ? 19  GLN A N   1 
ATOM   194  C  CA  . GLN A 1 22  ? -49.57590 21.58801  -0.66802  1.000 18.44659 ? 19  GLN A CA  1 
ATOM   195  C  C   . GLN A 1 22  ? -50.69670 22.57012  -0.95564  1.000 21.01593 ? 19  GLN A C   1 
ATOM   196  O  O   . GLN A 1 22  ? -50.76964 23.65275  -0.36026  1.000 22.47334 ? 19  GLN A O   1 
ATOM   197  C  CB  . GLN A 1 22  ? -50.07865 20.55601  0.35934   1.000 19.73736 ? 19  GLN A CB  1 
ATOM   198  C  CG  . GLN A 1 22  ? -48.99153 19.67734  0.96405   1.000 20.87209 ? 19  GLN A CG  1 
ATOM   199  C  CD  . GLN A 1 22  ? -48.43590 18.68125  -0.00858  1.000 27.08220 ? 19  GLN A CD  1 
ATOM   200  O  OE1 . GLN A 1 22  ? -48.95810 18.51412  -1.11074  1.000 26.29217 ? 19  GLN A OE1 1 
ATOM   201  N  NE2 . GLN A 1 22  ? -47.35787 18.00416  0.38987   1.000 24.03023 ? 19  GLN A NE2 1 
ATOM   202  N  N   . VAL A 1 23  ? -51.58428 22.17833  -1.85775  1.000 20.55812 ? 20  VAL A N   1 
ATOM   203  C  CA  . VAL A 1 23  ? -52.83347 22.89644  -2.09463  1.000 28.74449 ? 20  VAL A CA  1 
ATOM   204  C  C   . VAL A 1 23  ? -53.95704 21.93492  -1.73147  1.000 23.70631 ? 20  VAL A C   1 
ATOM   205  O  O   . VAL A 1 23  ? -54.00647 20.81974  -2.25258  1.000 29.12254 ? 20  VAL A O   1 
ATOM   206  C  CB  . VAL A 1 23  ? -52.92736 23.39362  -3.55102  1.000 28.36457 ? 20  VAL A CB  1 
ATOM   207  C  CG1 . VAL A 1 23  ? -54.27624 24.06874  -3.85226  1.000 24.35130 ? 20  VAL A CG1 1 
ATOM   208  C  CG2 . VAL A 1 23  ? -51.80168 24.38617  -3.83349  1.000 32.50510 ? 20  VAL A CG2 1 
ATOM   209  N  N   . VAL A 1 24  ? -54.81559 22.32130  -0.79213  1.000 23.98456 ? 21  VAL A N   1 
ATOM   210  C  CA  . VAL A 1 24  ? -55.86992 21.43026  -0.32456  1.000 24.09253 ? 21  VAL A CA  1 
ATOM   211  C  C   . VAL A 1 24  ? -57.22653 21.95983  -0.75615  1.000 26.15525 ? 21  VAL A C   1 
ATOM   212  O  O   . VAL A 1 24  ? -57.46621 23.17019  -0.75851  1.000 26.67484 ? 21  VAL A O   1 
ATOM   213  C  CB  . VAL A 1 24  ? -55.84716 21.21449  1.20203   1.000 25.21698 ? 21  VAL A CB  1 
ATOM   214  C  CG1 . VAL A 1 24  ? -54.61852 20.41376  1.58347   1.000 28.06831 ? 21  VAL A CG1 1 
ATOM   215  C  CG2 . VAL A 1 24  ? -55.91012 22.52551  1.95671   1.000 22.86364 ? 21  VAL A CG2 1 
ATOM   216  N  N   . ASP A 1 25  ? -58.10925 21.03749  -1.10236  1.000 25.04615 ? 22  ASP A N   1 
ATOM   217  C  CA  . ASP A 1 25  ? -59.49064 21.34364  -1.43329  1.000 23.37791 ? 22  ASP A CA  1 
ATOM   218  C  C   . ASP A 1 25  ? -60.30093 21.48673  -0.14843  1.000 25.73018 ? 22  ASP A C   1 
ATOM   219  O  O   . ASP A 1 25  ? -60.39320 20.54189  0.64624   1.000 24.77735 ? 22  ASP A O   1 
ATOM   220  C  CB  . ASP A 1 25  ? -60.03826 20.22275  -2.30973  1.000 27.77041 ? 22  ASP A CB  1 
ATOM   221  C  CG  . ASP A 1 25  ? -61.42643 20.52184  -2.84764  1.000 33.96751 ? 22  ASP A CG  1 
ATOM   222  O  OD1 . ASP A 1 25  ? -62.30859 21.00056  -2.08638  1.000 26.84892 ? 22  ASP A OD1 1 
ATOM   223  O  OD2 . ASP A 1 25  ? -61.60604 20.27584  -4.04979  1.000 28.55714 ? 22  ASP A OD2 1 
ATOM   224  N  N   . MET A 1 26  ? -60.91253 22.65600  0.05085   1.000 25.14177 ? 23  MET A N   1 
ATOM   225  C  CA  . MET A 1 26  ? -61.60376 22.87389  1.31183   1.000 25.86146 ? 23  MET A CA  1 
ATOM   226  C  C   . MET A 1 26  ? -62.88888 22.06011  1.43141   1.000 26.75140 ? 23  MET A C   1 
ATOM   227  O  O   . MET A 1 26  ? -63.51158 22.07614  2.49694   1.000 26.01542 ? 23  MET A O   1 
ATOM   228  C  CB  . MET A 1 26  ? -61.87877 24.36441  1.49811   1.000 25.34706 ? 23  MET A CB  1 
ATOM   229  C  CG  . MET A 1 26  ? -60.58903 25.19183  1.43235   1.000 20.77565 ? 23  MET A CG  1 
ATOM   230  S  SD  . MET A 1 26  ? -60.88380 26.90032  1.88478   1.000 30.50082 ? 23  MET A SD  1 
ATOM   231  C  CE  . MET A 1 26  ? -60.81138 26.79251  3.67259   1.000 35.43238 ? 23  MET A CE  1 
ATOM   232  N  N   . SER A 1 27  ? -63.28127 21.32993  0.38916   1.000 25.04341 ? 24  SER A N   1 
ATOM   233  C  CA  . SER A 1 27  ? -64.44524 20.45759  0.47059   1.000 35.24923 ? 24  SER A CA  1 
ATOM   234  C  C   . SER A 1 27  ? -64.09214 19.01137  0.81763   1.000 35.01307 ? 24  SER A C   1 
ATOM   235  O  O   . SER A 1 27  ? -65.00206 18.20039  1.00309   1.000 33.38128 ? 24  SER A O   1 
ATOM   236  C  CB  . SER A 1 27  ? -65.21667 20.47491  -0.85325  1.000 31.63619 ? 24  SER A CB  1 
ATOM   237  O  OG  . SER A 1 27  ? -64.52720 19.71453  -1.83449  1.000 26.11273 ? 24  SER A OG  1 
ATOM   238  N  N   . MET A 1 28  ? -62.80999 18.66247  0.88644   1.000 33.50990 ? 25  MET A N   1 
ATOM   239  C  CA  . MET A 1 28  ? -62.37764 17.32503  1.27566   1.000 29.10372 ? 25  MET A CA  1 
ATOM   240  C  C   . MET A 1 28  ? -61.69116 17.37387  2.63789   1.000 29.11585 ? 25  MET A C   1 
ATOM   241  O  O   . MET A 1 28  ? -61.14017 18.40173  3.02951   1.000 23.14445 ? 25  MET A O   1 
ATOM   242  C  CB  . MET A 1 28  ? -61.43277 16.74109  0.23417   1.000 30.66465 ? 25  MET A CB  1 
ATOM   243  C  CG  . MET A 1 28  ? -62.09700 16.50803  -1.09732  1.000 34.43971 ? 25  MET A CG  1 
ATOM   244  S  SD  . MET A 1 28  ? -60.87796 16.32608  -2.38954  1.000 39.45044 ? 25  MET A SD  1 
ATOM   245  C  CE  . MET A 1 28  ? -60.40239 14.61265  -2.19865  1.000 39.77210 ? 25  MET A CE  1 
ATOM   246  N  N   . THR A 1 29  ? -61.74876 16.27220  3.38117   1.000 28.55860 ? 26  THR A N   1 
ATOM   247  C  CA  . THR A 1 29  ? -61.02865 16.27449  4.64575   1.000 27.07103 ? 26  THR A CA  1 
ATOM   248  C  C   . THR A 1 29  ? -59.52501 16.23799  4.39115   1.000 27.65579 ? 26  THR A C   1 
ATOM   249  O  O   . THR A 1 29  ? -59.06235 15.85015  3.31463   1.000 21.67766 ? 26  THR A O   1 
ATOM   250  C  CB  . THR A 1 29  ? -61.43134 15.08603  5.53014   1.000 29.67138 ? 26  THR A CB  1 
ATOM   251  O  OG1 . THR A 1 29  ? -61.02790 13.85694  4.91610   1.000 29.69899 ? 26  THR A OG1 1 
ATOM   252  C  CG2 . THR A 1 29  ? -62.94324 15.07695  5.74892   1.000 24.94949 ? 26  THR A CG2 1 
ATOM   253  N  N   . TYR A 1 30  ? -58.75714 16.65483  5.40732   1.000 23.51801 ? 27  TYR A N   1 
ATOM   254  C  CA  . TYR A 1 30  ? -57.32149 16.41287  5.35824   1.000 24.46014 ? 27  TYR A CA  1 
ATOM   255  C  C   . TYR A 1 30  ? -57.02921 14.94211  5.11885   1.000 23.67907 ? 27  TYR A C   1 
ATOM   256  O  O   . TYR A 1 30  ? -56.18406 14.60120  4.28636   1.000 20.87099 ? 27  TYR A O   1 
ATOM   257  C  CB  . TYR A 1 30  ? -56.64799 16.89032  6.64524   1.000 19.78978 ? 27  TYR A CB  1 
ATOM   258  C  CG  . TYR A 1 30  ? -56.56388 18.38895  6.68370   1.000 23.45872 ? 27  TYR A CG  1 
ATOM   259  C  CD1 . TYR A 1 30  ? -55.72164 19.06625  5.80955   1.000 18.73199 ? 27  TYR A CD1 1 
ATOM   260  C  CD2 . TYR A 1 30  ? -57.35143 19.12756  7.55290   1.000 19.71948 ? 27  TYR A CD2 1 
ATOM   261  C  CE1 . TYR A 1 30  ? -55.63834 20.44161  5.81105   1.000 20.31148 ? 27  TYR A CE1 1 
ATOM   262  C  CE2 . TYR A 1 30  ? -57.28083 20.52814  7.57142   1.000 23.49342 ? 27  TYR A CE2 1 
ATOM   263  C  CZ  . TYR A 1 30  ? -56.43816 21.17314  6.69013   1.000 19.71962 ? 27  TYR A CZ  1 
ATOM   264  O  OH  . TYR A 1 30  ? -56.34533 22.56078  6.68918   1.000 21.46840 ? 27  TYR A OH  1 
ATOM   265  N  N   . GLY A 1 31  ? -57.74092 14.05226  5.82399   1.000 24.56422 ? 28  GLY A N   1 
ATOM   266  C  CA  . GLY A 1 31  ? -57.45907 12.63066  5.68930   1.000 24.25623 ? 28  GLY A CA  1 
ATOM   267  C  C   . GLY A 1 31  ? -57.62400 12.14087  4.26788   1.000 25.14031 ? 28  GLY A C   1 
ATOM   268  O  O   . GLY A 1 31  ? -56.85143 11.30291  3.79388   1.000 23.10315 ? 28  GLY A O   1 
ATOM   269  N  N   . GLN A 1 32  ? -58.62967 12.66266  3.56051   1.000 24.52519 ? 29  GLN A N   1 
ATOM   270  C  CA  . GLN A 1 32  ? -58.80177 12.28212  2.16471   1.000 26.97088 ? 29  GLN A CA  1 
ATOM   271  C  C   . GLN A 1 32  ? -57.65204 12.74621  1.28445   1.000 27.54464 ? 29  GLN A C   1 
ATOM   272  O  O   . GLN A 1 32  ? -57.48829 12.23492  0.17980   1.000 28.49046 ? 29  GLN A O   1 
ATOM   273  C  CB  . GLN A 1 32  ? -60.09232 12.87044  1.60551   1.000 28.10581 ? 29  GLN A CB  1 
ATOM   274  C  CG  . GLN A 1 32  ? -61.35947 12.30883  2.18047   1.000 29.47160 ? 29  GLN A CG  1 
ATOM   275  C  CD  . GLN A 1 32  ? -62.55150 13.01995  1.59138   1.000 40.22597 ? 29  GLN A CD  1 
ATOM   276  O  OE1 . GLN A 1 32  ? -63.02583 14.02704  2.13160   1.000 32.07038 ? 29  GLN A OE1 1 
ATOM   277  N  NE2 . GLN A 1 32  ? -63.01798 12.52914  0.45111   1.000 43.79830 ? 29  GLN A NE2 1 
ATOM   278  N  N   . GLN A 1 33  ? -56.88137 13.73534  1.71553   1.000 26.16292 ? 30  GLN A N   1 
ATOM   279  C  CA  . GLN A 1 33  ? -55.85288 14.30855  0.86076   1.000 22.59289 ? 30  GLN A CA  1 
ATOM   280  C  C   . GLN A 1 33  ? -54.43467 13.96894  1.31788   1.000 24.28749 ? 30  GLN A C   1 
ATOM   281  O  O   . GLN A 1 33  ? -53.53292 13.86273  0.48581   1.000 24.56894 ? 30  GLN A O   1 
ATOM   282  C  CB  . GLN A 1 33  ? -56.03726 15.83359  0.79370   1.000 23.17006 ? 30  GLN A CB  1 
ATOM   283  C  CG  . GLN A 1 33  ? -57.48047 16.21749  0.34015   1.000 25.75725 ? 30  GLN A CG  1 
ATOM   284  C  CD  . GLN A 1 33  ? -57.76888 17.70928  0.34746   1.000 22.53057 ? 30  GLN A CD  1 
ATOM   285  O  OE1 . GLN A 1 33  ? -57.37543 18.43001  -0.56356  1.000 26.06175 ? 30  GLN A OE1 1 
ATOM   286  N  NE2 . GLN A 1 33  ? -58.47551 18.17859  1.38264   1.000 23.41303 ? 30  GLN A NE2 1 
ATOM   287  N  N   . PHE A 1 34  ? -54.21994 13.76002  2.60954   1.000 25.68058 ? 31  PHE A N   1 
ATOM   288  C  CA  . PHE A 1 34  ? -52.88208 13.50298  3.12742   1.000 21.65312 ? 31  PHE A CA  1 
ATOM   289  C  C   . PHE A 1 34  ? -52.74022 12.15066  3.81116   1.000 25.00056 ? 31  PHE A C   1 
ATOM   290  O  O   . PHE A 1 34  ? -51.61287 11.76422  4.13743   1.000 26.60819 ? 31  PHE A O   1 
ATOM   291  C  CB  . PHE A 1 34  ? -52.49087 14.57517  4.15381   1.000 22.10749 ? 31  PHE A CB  1 
ATOM   292  C  CG  . PHE A 1 34  ? -52.38873 15.96915  3.60569   1.000 24.05503 ? 31  PHE A CG  1 
ATOM   293  C  CD1 . PHE A 1 34  ? -52.06247 16.19864  2.28165   1.000 25.74211 ? 31  PHE A CD1 1 
ATOM   294  C  CD2 . PHE A 1 34  ? -52.55286 17.05383  4.45184   1.000 22.07872 ? 31  PHE A CD2 1 
ATOM   295  C  CE1 . PHE A 1 34  ? -51.94075 17.49073  1.79430   1.000 24.86317 ? 31  PHE A CE1 1 
ATOM   296  C  CE2 . PHE A 1 34  ? -52.43608 18.34965  3.98356   1.000 27.46476 ? 31  PHE A CE2 1 
ATOM   297  C  CZ  . PHE A 1 34  ? -52.11630 18.56866  2.64084   1.000 22.52042 ? 31  PHE A CZ  1 
ATOM   298  N  N   . GLY A 1 35  ? -53.83816 11.43800  4.06432   1.000 22.81791 ? 32  GLY A N   1 
ATOM   299  C  CA  . GLY A 1 35  ? -53.86589 10.43854  5.11224   1.000 22.08278 ? 32  GLY A CA  1 
ATOM   300  C  C   . GLY A 1 35  ? -53.94076 11.10851  6.47116   1.000 24.14327 ? 32  GLY A C   1 
ATOM   301  O  O   . GLY A 1 35  ? -54.28264 12.29406  6.58563   1.000 25.43271 ? 32  GLY A O   1 
ATOM   302  N  N   . PRO A 1 36  ? -53.62868 10.36891  7.53289   1.000 21.39246 ? 33  PRO A N   1 
ATOM   303  C  CA  . PRO A 1 36  ? -53.65139 10.95929  8.87867   1.000 22.19461 ? 33  PRO A CA  1 
ATOM   304  C  C   . PRO A 1 36  ? -52.84194 12.25398  8.95066   1.000 22.00330 ? 33  PRO A C   1 
ATOM   305  O  O   . PRO A 1 36  ? -51.68197 12.30680  8.52966   1.000 23.12023 ? 33  PRO A O   1 
ATOM   306  C  CB  . PRO A 1 36  ? -53.03488 9.85784   9.75090   1.000 23.97815 ? 33  PRO A CB  1 
ATOM   307  C  CG  . PRO A 1 36  ? -53.33593 8.58246   8.99584   1.000 23.85460 ? 33  PRO A CG  1 
ATOM   308  C  CD  . PRO A 1 36  ? -53.21323 8.94930   7.54637   1.000 24.87390 ? 33  PRO A CD  1 
ATOM   309  N  N   . THR A 1 37  ? -53.45841 13.29415  9.52293   1.000 21.03941 ? 34  THR A N   1 
ATOM   310  C  CA  . THR A 1 37  ? -52.93342 14.65787  9.51654   1.000 18.83309 ? 34  THR A CA  1 
ATOM   311  C  C   . THR A 1 37  ? -53.14330 15.27535  10.88594  1.000 21.37790 ? 34  THR A C   1 
ATOM   312  O  O   . THR A 1 37  ? -54.17723 15.04621  11.52570  1.000 20.90572 ? 34  THR A O   1 
ATOM   313  C  CB  . THR A 1 37  ? -53.64395 15.51427  8.45779   1.000 20.08526 ? 34  THR A CB  1 
ATOM   314  O  OG1 . THR A 1 37  ? -53.52392 14.87021  7.19212   1.000 21.61090 ? 34  THR A OG1 1 
ATOM   315  C  CG2 . THR A 1 37  ? -53.04030 16.92362  8.37352   1.000 21.22627 ? 34  THR A CG2 1 
ATOM   316  N  N   . TYR A 1 38  ? -52.16212 16.05409  11.33834  1.000 18.85179 ? 35  TYR A N   1 
ATOM   317  C  CA  . TYR A 1 38  ? -52.21630 16.63516  12.66928  1.000 20.28985 ? 35  TYR A CA  1 
ATOM   318  C  C   . TYR A 1 38  ? -51.80549 18.09341  12.61148  1.000 23.14042 ? 35  TYR A C   1 
ATOM   319  O  O   . TYR A 1 38  ? -50.95558 18.49191  11.81583  1.000 18.98331 ? 35  TYR A O   1 
ATOM   320  C  CB  . TYR A 1 38  ? -51.31691 15.89343  13.66303  1.000 20.67215 ? 35  TYR A CB  1 
ATOM   321  C  CG  . TYR A 1 38  ? -51.57381 14.40814  13.68317  1.000 23.13317 ? 35  TYR A CG  1 
ATOM   322  C  CD1 . TYR A 1 38  ? -50.95992 13.56730  12.75965  1.000 24.06232 ? 35  TYR A CD1 1 
ATOM   323  C  CD2 . TYR A 1 38  ? -52.43216 13.84209  14.62976  1.000 22.70265 ? 35  TYR A CD2 1 
ATOM   324  C  CE1 . TYR A 1 38  ? -51.20847 12.19975  12.77115  1.000 22.24476 ? 35  TYR A CE1 1 
ATOM   325  C  CE2 . TYR A 1 38  ? -52.68535 12.47732  14.64871  1.000 22.08002 ? 35  TYR A CE2 1 
ATOM   326  C  CZ  . TYR A 1 38  ? -52.07496 11.66735  13.72019  1.000 25.22964 ? 35  TYR A CZ  1 
ATOM   327  O  OH  . TYR A 1 38  ? -52.32244 10.31794  13.72978  1.000 25.84318 ? 35  TYR A OH  1 
ATOM   328  N  N   . LEU A 1 39  ? -52.43131 18.88301  13.45890  1.000 21.58384 ? 36  LEU A N   1 
ATOM   329  C  CA  . LEU A 1 39  ? -52.16798 20.31037  13.54563  1.000 17.28732 ? 36  LEU A CA  1 
ATOM   330  C  C   . LEU A 1 39  ? -51.76766 20.54181  14.99331  1.000 27.64952 ? 36  LEU A C   1 
ATOM   331  O  O   . LEU A 1 39  ? -52.62131 20.53382  15.88631  1.000 27.51637 ? 36  LEU A O   1 
ATOM   332  C  CB  . LEU A 1 39  ? -53.39058 21.12300  13.14358  1.000 20.45858 ? 36  LEU A CB  1 
ATOM   333  C  CG  . LEU A 1 39  ? -53.24861 22.63780  13.28763  1.000 25.29564 ? 36  LEU A CG  1 
ATOM   334  C  CD1 . LEU A 1 39  ? -52.06137 23.11030  12.46707  1.000 20.60230 ? 36  LEU A CD1 1 
ATOM   335  C  CD2 . LEU A 1 39  ? -54.51607 23.32732  12.82571  1.000 22.88012 ? 36  LEU A CD2 1 
ATOM   336  N  N   . ASP A 1 40  ? -50.46177 20.66794  15.22793  1.000 28.77013 ? 37  ASP A N   1 
ATOM   337  C  CA  . ASP A 1 40  ? -49.91407 20.85297  16.56917  1.000 33.32376 ? 37  ASP A CA  1 
ATOM   338  C  C   . ASP A 1 40  ? -50.45473 19.79944  17.53697  1.000 24.91118 ? 37  ASP A C   1 
ATOM   339  O  O   . ASP A 1 40  ? -50.90520 20.10628  18.64097  1.000 25.82578 ? 37  ASP A O   1 
ATOM   340  C  CB  . ASP A 1 40  ? -50.20004 22.26623  17.07117  1.000 33.35982 ? 37  ASP A CB  1 
ATOM   341  C  CG  . ASP A 1 40  ? -49.21657 22.71417  18.14383  1.000 48.20955 ? 37  ASP A CG  1 
ATOM   342  O  OD1 . ASP A 1 40  ? -48.00084 22.39170  18.03354  1.000 37.59596 ? 37  ASP A OD1 1 
ATOM   343  O  OD2 . ASP A 1 40  ? -49.65960 23.40445  19.09285  1.000 52.43477 ? 37  ASP A OD2 1 
ATOM   344  N  N   . GLY A 1 41  ? -50.43440 18.54326  17.09335  1.000 22.75465 ? 38  GLY A N   1 
ATOM   345  C  CA  . GLY A 1 41  ? -50.86726 17.40916  17.88828  1.000 28.97180 ? 38  GLY A CA  1 
ATOM   346  C  C   . GLY A 1 41  ? -52.32615 17.03559  17.72141  1.000 26.98417 ? 38  GLY A C   1 
ATOM   347  O  O   . GLY A 1 41  ? -52.69047 15.86830  17.90863  1.000 23.42777 ? 38  GLY A O   1 
ATOM   348  N  N   . ALA A 1 42  ? -53.16371 17.99322  17.35155  1.000 23.04748 ? 39  ALA A N   1 
ATOM   349  C  CA  . ALA A 1 42  ? -54.57491 17.70233  17.14200  1.000 24.05329 ? 39  ALA A CA  1 
ATOM   350  C  C   . ALA A 1 42  ? -54.76450 16.89457  15.86567  1.000 20.23411 ? 39  ALA A C   1 
ATOM   351  O  O   . ALA A 1 42  ? -54.21630 17.22597  14.81276  1.000 23.88609 ? 39  ALA A O   1 
ATOM   352  C  CB  . ALA A 1 42  ? -55.37311 19.00605  17.07801  1.000 24.70933 ? 39  ALA A CB  1 
ATOM   353  N  N   . ASP A 1 43  ? -55.56023 15.84243  15.95328  1.000 21.40570 ? 40  ASP A N   1 
ATOM   354  C  CA  . ASP A 1 43  ? -55.87752 15.01047  14.80237  1.000 20.32286 ? 40  ASP A CA  1 
ATOM   355  C  C   . ASP A 1 43  ? -56.92291 15.71768  13.94318  1.000 23.89873 ? 40  ASP A C   1 
ATOM   356  O  O   . ASP A 1 43  ? -58.08928 15.82737  14.33713  1.000 24.32180 ? 40  ASP A O   1 
ATOM   357  C  CB  . ASP A 1 43  ? -56.39423 13.66057  15.28028  1.000 22.94905 ? 40  ASP A CB  1 
ATOM   358  C  CG  . ASP A 1 43  ? -56.56402 12.68288  14.15223  1.000 24.18740 ? 40  ASP A CG  1 
ATOM   359  O  OD1 . ASP A 1 43  ? -56.51533 13.11322  12.98123  1.000 25.58517 ? 40  ASP A OD1 1 
ATOM   360  O  OD2 . ASP A 1 43  ? -56.72287 11.47442  14.43182  1.000 30.35711 ? 40  ASP A OD2 1 
ATOM   361  N  N   . VAL A 1 44  ? -56.52563 16.17959  12.76022  1.000 21.68235 ? 41  VAL A N   1 
ATOM   362  C  CA  . VAL A 1 44  ? -57.44903 16.85821  11.87107  1.000 21.65664 ? 41  VAL A CA  1 
ATOM   363  C  C   . VAL A 1 44  ? -57.76731 15.98765  10.66311  1.000 20.41423 ? 41  VAL A C   1 
ATOM   364  O  O   . VAL A 1 44  ? -58.26067 16.48147  9.65501   1.000 23.24606 ? 41  VAL A O   1 
ATOM   365  C  CB  . VAL A 1 44  ? -56.92166 18.23965  11.44730  1.000 20.83263 ? 41  VAL A CB  1 
ATOM   366  C  CG1 . VAL A 1 44  ? -56.73941 19.12918  12.65422  1.000 24.06238 ? 41  VAL A CG1 1 
ATOM   367  C  CG2 . VAL A 1 44  ? -55.61709 18.10234  10.66263  1.000 19.76165 ? 41  VAL A CG2 1 
ATOM   368  N  N   . THR A 1 45  ? -57.48431 14.68898  10.76844  1.000 20.06468 ? 42  THR A N   1 
ATOM   369  C  CA  . THR A 1 45  ? -57.72910 13.77276  9.66256   1.000 19.41988 ? 42  THR A CA  1 
ATOM   370  C  C   . THR A 1 45  ? -59.15400 13.90378  9.13001   1.000 24.56779 ? 42  THR A C   1 
ATOM   371  O  O   . THR A 1 45  ? -59.37559 13.88785  7.91640   1.000 23.41430 ? 42  THR A O   1 
ATOM   372  C  CB  . THR A 1 45  ? -57.45572 12.34269  10.12565  1.000 25.81734 ? 42  THR A CB  1 
ATOM   373  O  OG1 . THR A 1 45  ? -56.11615 12.26697  10.63410  1.000 20.17243 ? 42  THR A OG1 1 
ATOM   374  C  CG2 . THR A 1 45  ? -57.64156 11.34280  8.99277   1.000 23.43399 ? 42  THR A CG2 1 
ATOM   375  N  N   . LYS A 1 46  ? -60.12961 14.03287  10.02578  1.000 23.85800 ? 43  LYS A N   1 
ATOM   376  C  CA  . LYS A 1 46  ? -61.53688 14.07564  9.64593   1.000 30.53396 ? 43  LYS A CA  1 
ATOM   377  C  C   . LYS A 1 46  ? -62.06608 15.49894  9.54204   1.000 30.15575 ? 43  LYS A C   1 
ATOM   378  O  O   . LYS A 1 46  ? -63.28129 15.68718  9.42482   1.000 27.31013 ? 43  LYS A O   1 
ATOM   379  C  CB  . LYS A 1 46  ? -62.37558 13.28024  10.64881  1.000 26.37742 ? 43  LYS A CB  1 
ATOM   380  C  CG  . LYS A 1 46  ? -62.07679 11.78546  10.66931  1.000 31.16634 ? 43  LYS A CG  1 
ATOM   381  C  CD  . LYS A 1 46  ? -62.82658 11.13075  11.83027  1.000 40.04966 ? 43  LYS A CD  1 
ATOM   382  C  CE  . LYS A 1 46  ? -62.55510 9.64083   11.92944  1.000 43.60119 ? 43  LYS A CE  1 
ATOM   383  N  NZ  . LYS A 1 46  ? -63.42465 8.85694   11.00392  1.000 60.00438 ? 43  LYS A NZ  1 
ATOM   384  N  N   . ILE A 1 47  ? -61.17846 16.49738  9.57900   1.000 26.05012 ? 44  ILE A N   1 
ATOM   385  C  CA  . ILE A 1 47  ? -61.53150 17.91774  9.53636   1.000 26.48596 ? 44  ILE A CA  1 
ATOM   386  C  C   . ILE A 1 47  ? -61.38839 18.39455  8.09650   1.000 30.08422 ? 44  ILE A C   1 
ATOM   387  O  O   . ILE A 1 47  ? -60.47579 17.96957  7.37705   1.000 26.21531 ? 44  ILE A O   1 
ATOM   388  C  CB  . ILE A 1 47  ? -60.63158 18.73584  10.49545  1.000 28.81810 ? 44  ILE A CB  1 
ATOM   389  C  CG1 . ILE A 1 47  ? -60.87131 18.36365  11.96395  1.000 32.32986 ? 44  ILE A CG1 1 
ATOM   390  C  CG2 . ILE A 1 47  ? -60.77971 20.22622  10.30291  1.000 29.02373 ? 44  ILE A CG2 1 
ATOM   391  C  CD1 . ILE A 1 47  ? -62.29301 18.38327  12.37635  1.000 30.70678 ? 44  ILE A CD1 1 
ATOM   392  N  N   . LYS A 1 48  ? -62.31026 19.23676  7.65486   1.000 27.92916 ? 45  LYS A N   1 
ATOM   393  C  CA  . LYS A 1 48  ? -62.08819 19.85565  6.35672   1.000 24.56926 ? 45  LYS A CA  1 
ATOM   394  C  C   . LYS A 1 48  ? -61.44192 21.21378  6.55091   1.000 21.71148 ? 45  LYS A C   1 
ATOM   395  O  O   . LYS A 1 48  ? -61.72508 21.88872  7.53687   1.000 24.49134 ? 45  LYS A O   1 
ATOM   396  C  CB  . LYS A 1 48  ? -63.40534 20.02008  5.58724   1.000 29.20896 ? 45  LYS A CB  1 
ATOM   397  C  CG  . LYS A 1 48  ? -64.09815 18.70461  5.31432   1.000 26.42553 ? 45  LYS A CG  1 
ATOM   398  C  CD  . LYS A 1 48  ? -65.39767 18.88389  4.54773   1.000 30.08047 ? 45  LYS A CD  1 
ATOM   399  C  CE  . LYS A 1 48  ? -65.84889 17.54155  4.01766   1.000 29.60128 ? 45  LYS A CE  1 
ATOM   400  N  NZ  . LYS A 1 48  ? -67.29773 17.51070  3.70216   1.000 46.89050 ? 45  LYS A NZ  1 
ATOM   401  N  N   . PRO A 1 49  ? -60.57560 21.62771  5.62954   1.000 22.75035 ? 46  PRO A N   1 
ATOM   402  C  CA  . PRO A 1 49  ? -59.75202 22.82903  5.85108   1.000 23.69195 ? 46  PRO A CA  1 
ATOM   403  C  C   . PRO A 1 49  ? -60.55166 24.07708  6.20525   1.000 29.94141 ? 46  PRO A C   1 
ATOM   404  O  O   . PRO A 1 49  ? -61.61638 24.33418  5.64037   1.000 28.12267 ? 46  PRO A O   1 
ATOM   405  C  CB  . PRO A 1 49  ? -59.04103 23.01209  4.51002   1.000 24.83492 ? 46  PRO A CB  1 
ATOM   406  C  CG  . PRO A 1 49  ? -58.93770 21.60910  3.96183   1.000 21.94037 ? 46  PRO A CG  1 
ATOM   407  C  CD  . PRO A 1 49  ? -60.17253 20.88580  4.42943   1.000 20.01162 ? 46  PRO A CD  1 
ATOM   408  N  N   . HIS A 1 50  ? -59.99446 24.87459  7.12555   1.000 25.30172 ? 47  HIS A N   1 
ATOM   409  C  CA  . HIS A 1 50  ? -60.50881 26.18779  7.48617   1.000 30.98689 ? 47  HIS A CA  1 
ATOM   410  C  C   . HIS A 1 50  ? -59.64354 27.27080  6.85558   1.000 32.27216 ? 47  HIS A C   1 
ATOM   411  O  O   . HIS A 1 50  ? -58.44789 27.08382  6.61786   1.000 28.44660 ? 47  HIS A O   1 
ATOM   412  C  CB  . HIS A 1 50  ? -60.52120 26.40253  9.00391   1.000 28.01909 ? 47  HIS A CB  1 
ATOM   413  C  CG  . HIS A 1 50  ? -61.30598 25.38405  9.76930   1.000 32.97880 ? 47  HIS A CG  1 
ATOM   414  N  ND1 . HIS A 1 50  ? -61.50101 25.47562  11.13209  1.000 36.01120 ? 47  HIS A ND1 1 
ATOM   415  C  CD2 . HIS A 1 50  ? -61.93398 24.24986  9.37315   1.000 33.36729 ? 47  HIS A CD2 1 
ATOM   416  C  CE1 . HIS A 1 50  ? -62.21185 24.44006  11.54428  1.000 35.00282 ? 47  HIS A CE1 1 
ATOM   417  N  NE2 . HIS A 1 50  ? -62.49606 23.68698  10.49473  1.000 43.35314 ? 47  HIS A NE2 1 
ATOM   418  N  N   A ASN A 1 51  ? -60.25603 28.41984  6.58580   0.549 29.44755 ? 48  ASN A N   1 
ATOM   419  N  N   B ASN A 1 51  ? -60.26186 28.42089  6.60094   0.451 29.45255 ? 48  ASN A N   1 
ATOM   420  C  CA  A ASN A 1 51  ? -59.47814 29.54090  6.06737   0.549 29.53253 ? 48  ASN A CA  1 
ATOM   421  C  CA  B ASN A 1 51  ? -59.50767 29.55197  6.07272   0.451 29.54936 ? 48  ASN A CA  1 
ATOM   422  C  C   A ASN A 1 51  ? -58.32755 29.89466  7.00172   0.549 28.45672 ? 48  ASN A C   1 
ATOM   423  C  C   B ASN A 1 51  ? -58.35302 29.92566  6.99904   0.451 28.45897 ? 48  ASN A C   1 
ATOM   424  O  O   A ASN A 1 51  ? -57.23244 30.24451  6.54866   0.549 27.13276 ? 48  ASN A O   1 
ATOM   425  O  O   B ASN A 1 51  ? -57.27436 30.31239  6.53531   0.451 27.15082 ? 48  ASN A O   1 
ATOM   426  C  CB  A ASN A 1 51  ? -60.38282 30.75683  5.84773   0.549 30.77443 ? 48  ASN A CB  1 
ATOM   427  C  CB  B ASN A 1 51  ? -60.44561 30.74438  5.85323   0.451 30.76558 ? 48  ASN A CB  1 
ATOM   428  C  CG  A ASN A 1 51  ? -61.14855 30.67696  4.55278   0.549 30.15885 ? 48  ASN A CG  1 
ATOM   429  C  CG  B ASN A 1 51  ? -59.75452 31.91104  5.18620   0.451 29.43872 ? 48  ASN A CG  1 
ATOM   430  O  OD1 A ASN A 1 51  ? -60.60655 30.27346  3.51397   0.549 33.09196 ? 48  ASN A OD1 1 
ATOM   431  O  OD1 B ASN A 1 51  ? -59.56692 32.96245  5.79279   0.451 31.68756 ? 48  ASN A OD1 1 
ATOM   432  N  ND2 A ASN A 1 51  ? -62.41704 31.05528  4.59922   0.549 34.76369 ? 48  ASN A ND2 1 
ATOM   433  N  ND2 B ASN A 1 51  ? -59.34979 31.72269  3.93317   0.451 32.22760 ? 48  ASN A ND2 1 
ATOM   434  N  N   . SER A 1 52  ? -58.55285 29.79795  8.31215   1.000 23.74398 ? 49  SER A N   1 
ATOM   435  C  CA  . SER A 1 52  ? -57.49909 30.10058  9.27465   1.000 25.83074 ? 49  SER A CA  1 
ATOM   436  C  C   . SER A 1 52  ? -56.31994 29.14201  9.16846   1.000 28.45926 ? 49  SER A C   1 
ATOM   437  O  O   . SER A 1 52  ? -55.26924 29.40093  9.76957   1.000 29.80503 ? 49  SER A O   1 
ATOM   438  C  CB  . SER A 1 52  ? -58.05261 30.01600  10.68396  1.000 29.43774 ? 49  SER A CB  1 
ATOM   439  O  OG  . SER A 1 52  ? -58.20450 28.65158  11.01620  1.000 26.42689 ? 49  SER A OG  1 
ATOM   440  N  N   . HIS A 1 53  ? -56.48751 28.03103  8.45657   1.000 23.95897 ? 50  HIS A N   1 
ATOM   441  C  CA  . HIS A 1 53  ? -55.41792 27.06771  8.26393   1.000 28.00286 ? 50  HIS A CA  1 
ATOM   442  C  C   . HIS A 1 53  ? -54.41467 27.51322  7.21706   1.000 25.86695 ? 50  HIS A C   1 
ATOM   443  O  O   . HIS A 1 53  ? -53.33748 26.91235  7.12235   1.000 22.50669 ? 50  HIS A O   1 
ATOM   444  C  CB  . HIS A 1 53  ? -55.99126 25.71352  7.85190   1.000 22.61708 ? 50  HIS A CB  1 
ATOM   445  C  CG  . HIS A 1 53  ? -56.73250 25.00550  8.94313   1.000 24.55573 ? 50  HIS A CG  1 
ATOM   446  N  ND1 . HIS A 1 53  ? -57.58340 23.94903  8.69240   1.000 24.50539 ? 50  HIS A ND1 1 
ATOM   447  C  CD2 . HIS A 1 53  ? -56.74279 25.18877  10.28311  1.000 25.10185 ? 50  HIS A CD2 1 
ATOM   448  C  CE1 . HIS A 1 53  ? -58.09236 23.51832  9.83214   1.000 24.11568 ? 50  HIS A CE1 1 
ATOM   449  N  NE2 . HIS A 1 53  ? -57.59750 24.24943  10.81139  1.000 24.33044 ? 50  HIS A NE2 1 
ATOM   450  N  N   . GLU A 1 54  ? -54.74059 28.52740  6.42116   1.000 24.39607 ? 51  GLU A N   1 
ATOM   451  C  CA  . GLU A 1 54  ? -53.86915 28.89171  5.31830   1.000 23.82931 ? 51  GLU A CA  1 
ATOM   452  C  C   . GLU A 1 54  ? -52.47662 29.21385  5.82469   1.000 21.96158 ? 51  GLU A C   1 
ATOM   453  O  O   . GLU A 1 54  ? -52.32095 29.98550  6.77084   1.000 27.80366 ? 51  GLU A O   1 
ATOM   454  C  CB  . GLU A 1 54  ? -54.42007 30.09383  4.56212   1.000 26.41697 ? 51  GLU A CB  1 
ATOM   455  C  CG  . GLU A 1 54  ? -53.48390 30.48770  3.43731   1.000 24.90758 ? 51  GLU A CG  1 
ATOM   456  C  CD  . GLU A 1 54  ? -54.20806 30.79444  2.16253   1.000 44.70647 ? 51  GLU A CD  1 
ATOM   457  O  OE1 . GLU A 1 54  ? -54.94045 31.80558  2.17518   1.000 40.26010 ? 51  GLU A OE1 1 
ATOM   458  O  OE2 . GLU A 1 54  ? -54.06558 30.02284  1.16497   1.000 41.33845 ? 51  GLU A OE2 1 
ATOM   459  N  N   . GLY A 1 55  ? -51.46516 28.61051  5.19901   1.000 24.00110 ? 52  GLY A N   1 
ATOM   460  C  CA  . GLY A 1 55  ? -50.07775 28.83883  5.55475   1.000 22.21210 ? 52  GLY A CA  1 
ATOM   461  C  C   . GLY A 1 55  ? -49.57984 28.07454  6.76240   1.000 20.49856 ? 52  GLY A C   1 
ATOM   462  O  O   . GLY A 1 55  ? -48.39873 28.20800  7.11664   1.000 20.31977 ? 52  GLY A O   1 
ATOM   463  N  N   . LYS A 1 56  ? -50.44145 27.30890  7.42384   1.000 21.89611 ? 53  LYS A N   1 
ATOM   464  C  CA  . LYS A 1 56  ? -50.04064 26.58704  8.61189   1.000 21.53446 ? 53  LYS A CA  1 
ATOM   465  C  C   . LYS A 1 56  ? -49.37009 25.26110  8.24999   1.000 21.79616 ? 53  LYS A C   1 
ATOM   466  O  O   . LYS A 1 56  ? -49.50462 24.73659  7.14085   1.000 18.67795 ? 53  LYS A O   1 
ATOM   467  C  CB  . LYS A 1 56  ? -51.24669 26.35844  9.52838   1.000 21.15996 ? 53  LYS A CB  1 
ATOM   468  C  CG  . LYS A 1 56  ? -51.68536 27.65972  10.22608  1.000 21.41247 ? 53  LYS A CG  1 
ATOM   469  C  CD  . LYS A 1 56  ? -52.73590 27.39537  11.30104  1.000 26.74812 ? 53  LYS A CD  1 
ATOM   470  C  CE  . LYS A 1 56  ? -52.96833 28.65185  12.13626  1.000 28.31786 ? 53  LYS A CE  1 
ATOM   471  N  NZ  . LYS A 1 56  ? -54.08294 28.46289  13.12773  1.000 38.76364 ? 53  LYS A NZ  1 
ATOM   472  N  N   . THR A 1 57  ? -48.63994 24.72199  9.22225   1.000 19.38088 ? 54  THR A N   1 
ATOM   473  C  CA  . THR A 1 57  ? -47.89322 23.47944  9.06695   1.000 15.54931 ? 54  THR A CA  1 
ATOM   474  C  C   . THR A 1 57  ? -48.64262 22.32585  9.72464   1.000 16.40375 ? 54  THR A C   1 
ATOM   475  O  O   . THR A 1 57  ? -49.02319 22.41293  10.89150  1.000 22.05699 ? 54  THR A O   1 
ATOM   476  C  CB  . THR A 1 57  ? -46.50316 23.62679  9.69067   1.000 21.53736 ? 54  THR A CB  1 
ATOM   477  O  OG1 . THR A 1 57  ? -45.74248 24.58122  8.94081   1.000 19.49012 ? 54  THR A OG1 1 
ATOM   478  C  CG2 . THR A 1 57  ? -45.78192 22.30831  9.69006   1.000 20.28690 ? 54  THR A CG2 1 
ATOM   479  N  N   . PHE A 1 58  ? -48.81209 21.24041  8.98284   1.000 17.78097 ? 55  PHE A N   1 
ATOM   480  C  CA  . PHE A 1 58  ? -49.46809 20.02707  9.43811   1.000 19.93002 ? 55  PHE A CA  1 
ATOM   481  C  C   . PHE A 1 58  ? -48.47847 18.86494  9.41449   1.000 21.79450 ? 55  PHE A C   1 
ATOM   482  O  O   . PHE A 1 58  ? -47.70316 18.72365  8.46837   1.000 21.53343 ? 55  PHE A O   1 
ATOM   483  C  CB  . PHE A 1 58  ? -50.66467 19.70204  8.52919   1.000 17.87593 ? 55  PHE A CB  1 
ATOM   484  C  CG  . PHE A 1 58  ? -51.74893 20.73613  8.58157   1.000 20.35110 ? 55  PHE A CG  1 
ATOM   485  C  CD1 . PHE A 1 58  ? -51.63965 21.91935  7.86652   1.000 23.17184 ? 55  PHE A CD1 1 
ATOM   486  C  CD2 . PHE A 1 58  ? -52.87800 20.53201  9.36246   1.000 23.43896 ? 55  PHE A CD2 1 
ATOM   487  C  CE1 . PHE A 1 58  ? -52.65933 22.89418  7.93850   1.000 20.39513 ? 55  PHE A CE1 1 
ATOM   488  C  CE2 . PHE A 1 58  ? -53.87521 21.47791  9.43452   1.000 19.65501 ? 55  PHE A CE2 1 
ATOM   489  C  CZ  . PHE A 1 58  ? -53.77081 22.66150  8.72142   1.000 24.30054 ? 55  PHE A CZ  1 
ATOM   490  N  N   . TYR A 1 59  ? -48.49107 18.04037  10.45458  1.000 19.88908 ? 56  TYR A N   1 
ATOM   491  C  CA  . TYR A 1 59  ? -47.72706 16.80435  10.40468  1.000 18.61080 ? 56  TYR A CA  1 
ATOM   492  C  C   . TYR A 1 59  ? -48.51824 15.74865  9.65225   1.000 22.31661 ? 56  TYR A C   1 
ATOM   493  O  O   . TYR A 1 59  ? -49.74499 15.66375  9.77482   1.000 23.45290 ? 56  TYR A O   1 
ATOM   494  C  CB  . TYR A 1 59  ? -47.42928 16.27726  11.79331  1.000 18.94431 ? 56  TYR A CB  1 
ATOM   495  C  CG  . TYR A 1 59  ? -46.31111 16.93007  12.54353  1.000 21.28773 ? 56  TYR A CG  1 
ATOM   496  C  CD1 . TYR A 1 59  ? -46.42315 18.23025  13.02740  1.000 23.03874 ? 56  TYR A CD1 1 
ATOM   497  C  CD2 . TYR A 1 59  ? -45.15525 16.22086  12.82147  1.000 21.22026 ? 56  TYR A CD2 1 
ATOM   498  C  CE1 . TYR A 1 59  ? -45.39091 18.79999  13.77182  1.000 25.21660 ? 56  TYR A CE1 1 
ATOM   499  C  CE2 . TYR A 1 59  ? -44.13570 16.77509  13.54483  1.000 20.66820 ? 56  TYR A CE2 1 
ATOM   500  C  CZ  . TYR A 1 59  ? -44.25905 18.05570  14.02796  1.000 24.22006 ? 56  TYR A CZ  1 
ATOM   501  O  OH  . TYR A 1 59  ? -43.23181 18.58750  14.76079  1.000 22.93557 ? 56  TYR A OH  1 
ATOM   502  N  N   . VAL A 1 60  ? -47.81138 14.93147  8.88973   1.000 19.32795 ? 57  VAL A N   1 
ATOM   503  C  CA  . VAL A 1 60  ? -48.39683 13.79888  8.20221   1.000 18.63176 ? 57  VAL A CA  1 
ATOM   504  C  C   . VAL A 1 60  ? -47.51562 12.58736  8.47949   1.000 22.33428 ? 57  VAL A C   1 
ATOM   505  O  O   . VAL A 1 60  ? -46.45694 12.70184  9.09297   1.000 20.27016 ? 57  VAL A O   1 
ATOM   506  C  CB  . VAL A 1 60  ? -48.55038 14.04421  6.68887   1.000 20.16818 ? 57  VAL A CB  1 
ATOM   507  C  CG1 . VAL A 1 60  ? -49.49077 15.22663  6.42855   1.000 17.70632 ? 57  VAL A CG1 1 
ATOM   508  C  CG2 . VAL A 1 60  ? -47.15399 14.24730  6.02791   1.000 19.99340 ? 57  VAL A CG2 1 
ATOM   509  N  N   . LEU A 1 61  ? -47.95861 11.43744  8.02205   1.000 21.87447 ? 58  LEU A N   1 
ATOM   510  C  CA  . LEU A 1 61  ? -47.15623 10.23470  8.17278   1.000 24.03457 ? 58  LEU A CA  1 
ATOM   511  C  C   . LEU A 1 61  ? -46.21238 10.10218  6.98288   1.000 24.66367 ? 58  LEU A C   1 
ATOM   512  O  O   . LEU A 1 61  ? -46.50440 10.61306  5.89279   1.000 25.99671 ? 58  LEU A O   1 
ATOM   513  C  CB  . LEU A 1 61  ? -48.05769 9.00074   8.26839   1.000 23.62471 ? 58  LEU A CB  1 
ATOM   514  C  CG  . LEU A 1 61  ? -49.09594 9.03702   9.39498   1.000 21.62503 ? 58  LEU A CG  1 
ATOM   515  C  CD1 . LEU A 1 61  ? -49.79936 7.66973   9.49306   1.000 24.93407 ? 58  LEU A CD1 1 
ATOM   516  C  CD2 . LEU A 1 61  ? -48.42717 9.40400   10.70126  1.000 25.55060 ? 58  LEU A CD2 1 
ATOM   517  N  N   . PRO A 1 62  ? -45.03503 9.46611   7.17082   1.000 26.15219 ? 59  PRO A N   1 
ATOM   518  C  CA  . PRO A 1 62  ? -44.08937 9.34491   6.05210   1.000 27.02776 ? 59  PRO A CA  1 
ATOM   519  C  C   . PRO A 1 62  ? -44.65455 8.41311   4.99157   1.000 33.91383 ? 59  PRO A C   1 
ATOM   520  O  O   . PRO A 1 62  ? -44.58957 7.19106   5.12955   1.000 37.00833 ? 59  PRO A O   1 
ATOM   521  C  CB  . PRO A 1 62  ? -42.81759 8.78103   6.70191   1.000 29.19601 ? 59  PRO A CB  1 
ATOM   522  C  CG  . PRO A 1 62  ? -42.99585 8.97300   8.19608   1.000 28.24351 ? 59  PRO A CG  1 
ATOM   523  C  CD  . PRO A 1 62  ? -44.49460 8.92597   8.42869   1.000 26.43942 ? 59  PRO A CD  1 
ATOM   524  N  N   . ASN A 1 63  ? -45.24747 8.98306   3.94604   1.000 35.43279 ? 60  ASN A N   1 
ATOM   525  C  CA  . ASN A 1 63  ? -45.94991 8.21928   2.92268   1.000 38.61195 ? 60  ASN A CA  1 
ATOM   526  C  C   . ASN A 1 63  ? -45.22239 8.23825   1.58807   1.000 45.19363 ? 60  ASN A C   1 
ATOM   527  O  O   . ASN A 1 63  ? -45.76923 7.76648   0.58776   1.000 46.96420 ? 60  ASN A O   1 
ATOM   528  C  CB  . ASN A 1 63  ? -47.37894 8.75895   2.76472   1.000 48.74148 ? 60  ASN A CB  1 
ATOM   529  C  CG  . ASN A 1 63  ? -47.42749 10.30340  2.61872   1.000 50.19335 ? 60  ASN A CG  1 
ATOM   530  O  OD1 . ASN A 1 63  ? -46.92617 10.86161  1.63736   1.000 53.14948 ? 60  ASN A OD1 1 
ATOM   531  N  ND2 . ASN A 1 63  ? -48.04964 10.98254  3.58586   1.000 36.96956 ? 60  ASN A ND2 1 
ATOM   532  N  N   . ASP A 1 64  ? -44.00846 8.78630   1.54542   1.000 35.18744 ? 61  ASP A N   1 
ATOM   533  C  CA  . ASP A 1 64  ? -43.19482 8.78904   0.33980   1.000 34.21329 ? 61  ASP A CA  1 
ATOM   534  C  C   . ASP A 1 64  ? -41.73210 8.79847   0.76254   1.000 34.11305 ? 61  ASP A C   1 
ATOM   535  O  O   . ASP A 1 64  ? -41.40366 8.99336   1.93806   1.000 29.42171 ? 61  ASP A O   1 
ATOM   536  C  CB  . ASP A 1 64  ? -43.53682 9.97790   -0.58348  1.000 30.77597 ? 61  ASP A CB  1 
ATOM   537  C  CG  . ASP A 1 64  ? -43.31122 11.33367  0.07166   1.000 36.31373 ? 61  ASP A CG  1 
ATOM   538  O  OD1 . ASP A 1 64  ? -42.18207 11.60758  0.54243   1.000 31.71553 ? 61  ASP A OD1 1 
ATOM   539  O  OD2 . ASP A 1 64  ? -44.26661 12.14120  0.10486   1.000 40.03435 ? 61  ASP A OD2 1 
ATOM   540  N  N   . ASP A 1 65  ? -40.84663 8.60229   -0.21695  1.000 31.00629 ? 62  ASP A N   1 
ATOM   541  C  CA  . ASP A 1 65  ? -39.44249 8.38962   0.10897   1.000 29.40639 ? 62  ASP A CA  1 
ATOM   542  C  C   . ASP A 1 65  ? -38.81412 9.62263   0.74595   1.000 28.33490 ? 62  ASP A C   1 
ATOM   543  O  O   . ASP A 1 65  ? -37.94535 9.49927   1.61265   1.000 25.07208 ? 62  ASP A O   1 
ATOM   544  C  CB  . ASP A 1 65  ? -38.67286 7.97984   -1.13906  1.000 32.35964 ? 62  ASP A CB  1 
ATOM   545  C  CG  . ASP A 1 65  ? -39.12936 6.63559   -1.67458  1.000 35.00410 ? 62  ASP A CG  1 
ATOM   546  O  OD1 . ASP A 1 65  ? -39.88252 5.92382   -0.95635  1.000 38.63175 ? 62  ASP A OD1 1 
ATOM   547  O  OD2 . ASP A 1 65  ? -38.73361 6.29116   -2.80661  1.000 45.17067 ? 62  ASP A OD2 1 
ATOM   548  N  N   . THR A 1 66  ? -39.21922 10.81570  0.31924   1.000 27.85055 ? 63  THR A N   1 
ATOM   549  C  CA  . THR A 1 66  ? -38.65683 12.02808  0.90629   1.000 22.82065 ? 63  THR A CA  1 
ATOM   550  C  C   . THR A 1 66  ? -38.98814 12.12942  2.38484   1.000 23.89564 ? 63  THR A C   1 
ATOM   551  O  O   . THR A 1 66  ? -38.11153 12.42360  3.20563   1.000 22.87675 ? 63  THR A O   1 
ATOM   552  C  CB  . THR A 1 66  ? -39.16971 13.25154  0.16402   1.000 28.44763 ? 63  THR A CB  1 
ATOM   553  O  OG1 . THR A 1 66  ? -38.65221 13.22042  -1.15866  1.000 29.18617 ? 63  THR A OG1 1 
ATOM   554  C  CG2 . THR A 1 66  ? -38.69595 14.52507  0.84172   1.000 25.90113 ? 63  THR A CG2 1 
ATOM   555  N  N   . LEU A 1 67  ? -40.25594 11.87824  2.74290   1.000 17.67496 ? 64  LEU A N   1 
ATOM   556  C  CA  . LEU A 1 67  ? -40.68328 11.98752  4.13217   1.000 25.24283 ? 64  LEU A CA  1 
ATOM   557  C  C   . LEU A 1 67  ? -40.09395 10.86847  4.98276   1.000 21.37008 ? 64  LEU A C   1 
ATOM   558  O  O   . LEU A 1 67  ? -39.77097 11.07957  6.16151   1.000 18.31907 ? 64  LEU A O   1 
ATOM   559  C  CB  . LEU A 1 67  ? -42.20858 11.96834  4.20623   1.000 18.12237 ? 64  LEU A CB  1 
ATOM   560  C  CG  . LEU A 1 67  ? -42.90414 13.18573  3.58769   1.000 23.78744 ? 64  LEU A CG  1 
ATOM   561  C  CD1 . LEU A 1 67  ? -44.40109 13.03615  3.70736   1.000 24.65502 ? 64  LEU A CD1 1 
ATOM   562  C  CD2 . LEU A 1 67  ? -42.40516 14.47402  4.24291   1.000 22.71111 ? 64  LEU A CD2 1 
ATOM   563  N  N   . ARG A 1 68  ? -39.95855 9.67333   4.40514   1.000 20.16026 ? 65  ARG A N   1 
ATOM   564  C  CA  . ARG A 1 68  ? -39.32835 8.56841   5.12602   1.000 22.67109 ? 65  ARG A CA  1 
ATOM   565  C  C   . ARG A 1 68  ? -37.90685 8.94012   5.53816   1.000 17.31397 ? 65  ARG A C   1 
ATOM   566  O  O   . ARG A 1 68  ? -37.49463 8.71942   6.68162   1.000 23.05754 ? 65  ARG A O   1 
ATOM   567  C  CB  . ARG A 1 68  ? -39.32327 7.31959   4.25166   1.000 23.98820 ? 65  ARG A CB  1 
ATOM   568  C  CG  . ARG A 1 68  ? -40.67244 6.59622   4.15681   1.000 27.27777 ? 65  ARG A CG  1 
ATOM   569  C  CD  . ARG A 1 68  ? -40.55137 5.30653   3.33006   1.000 35.25033 ? 65  ARG A CD  1 
ATOM   570  N  NE  . ARG A 1 68  ? -41.84503 4.72355   2.97213   1.000 38.63238 ? 65  ARG A NE  1 
ATOM   571  C  CZ  . ARG A 1 68  ? -42.55002 3.92165   3.76527   1.000 48.86507 ? 65  ARG A CZ  1 
ATOM   572  N  NH1 . ARG A 1 68  ? -42.14988 3.64178   5.00302   1.000 41.32971 ? 65  ARG A NH1 1 
ATOM   573  N  NH2 . ARG A 1 68  ? -43.68234 3.38363   3.30757   1.000 36.54547 ? 65  ARG A NH2 1 
ATOM   574  N  N   . VAL A 1 69  ? -37.14624 9.52011   4.61425   1.000 20.24742 ? 66  VAL A N   1 
ATOM   575  C  CA  . VAL A 1 69  ? -35.77438 9.90101   4.92949   1.000 21.77648 ? 66  VAL A CA  1 
ATOM   576  C  C   . VAL A 1 69  ? -35.75422 11.03731  5.94426   1.000 23.58259 ? 66  VAL A C   1 
ATOM   577  O  O   . VAL A 1 69  ? -34.98592 11.01391  6.91394   1.000 21.15934 ? 66  VAL A O   1 
ATOM   578  C  CB  . VAL A 1 69  ? -35.01052 10.26728  3.64763   1.000 20.64670 ? 66  VAL A CB  1 
ATOM   579  C  CG1 . VAL A 1 69  ? -33.65435 10.86047  3.99710   1.000 22.51573 ? 66  VAL A CG1 1 
ATOM   580  C  CG2 . VAL A 1 69  ? -34.85980 9.03627   2.77288   1.000 22.84159 ? 66  VAL A CG2 1 
ATOM   581  N  N   . GLU A 1 70  ? -36.58116 12.05794  5.73243   1.000 18.53208 ? 67  GLU A N   1 
ATOM   582  C  CA  . GLU A 1 70  ? -36.61893 13.15151  6.68927   1.000 22.54833 ? 67  GLU A CA  1 
ATOM   583  C  C   . GLU A 1 70  ? -36.97580 12.64042  8.07140   1.000 20.50332 ? 67  GLU A C   1 
ATOM   584  O  O   . GLU A 1 70  ? -36.36617 13.04649  9.06379   1.000 18.33671 ? 67  GLU A O   1 
ATOM   585  C  CB  . GLU A 1 70  ? -37.60541 14.23111  6.22816   1.000 21.24322 ? 67  GLU A CB  1 
ATOM   586  C  CG  . GLU A 1 70  ? -37.03201 15.11264  5.13182   1.000 19.54566 ? 67  GLU A CG  1 
ATOM   587  C  CD  . GLU A 1 70  ? -38.08050 16.02539  4.46980   1.000 27.02055 ? 67  GLU A CD  1 
ATOM   588  O  OE1 . GLU A 1 70  ? -39.21914 16.08081  4.95177   1.000 19.87545 ? 67  GLU A OE1 1 
ATOM   589  O  OE2 . GLU A 1 70  ? -37.76669 16.68293  3.45979   1.000 23.11821 ? 67  GLU A OE2 1 
ATOM   590  N  N   . ALA A 1 71  ? -37.92803 11.70672  8.15185   1.000 19.32605 ? 68  ALA A N   1 
ATOM   591  C  CA  . ALA A 1 71  ? -38.37394 11.23766  9.45545   1.000 22.22250 ? 68  ALA A CA  1 
ATOM   592  C  C   . ALA A 1 71  ? -37.29543 10.39243  10.11952  1.000 18.64525 ? 68  ALA A C   1 
ATOM   593  O  O   . ALA A 1 71  ? -37.03983 10.53158  11.32013  1.000 18.07049 ? 68  ALA A O   1 
ATOM   594  C  CB  . ALA A 1 71  ? -39.67813 10.44739  9.32313   1.000 15.08432 ? 68  ALA A CB  1 
ATOM   595  N  N   . PHE A 1 72  ? -36.65306 9.50637   9.36324   1.000 17.66823 ? 69  PHE A N   1 
ATOM   596  C  CA  . PHE A 1 72  ? -35.57811 8.73900   9.97262   1.000 17.84655 ? 69  PHE A CA  1 
ATOM   597  C  C   . PHE A 1 72  ? -34.43983 9.65933   10.40462  1.000 17.55130 ? 69  PHE A C   1 
ATOM   598  O  O   . PHE A 1 72  ? -33.89156 9.51261   11.50503  1.000 20.09337 ? 69  PHE A O   1 
ATOM   599  C  CB  . PHE A 1 72  ? -35.04621 7.66312   9.03021   1.000 18.76524 ? 69  PHE A CB  1 
ATOM   600  C  CG  . PHE A 1 72  ? -33.92729 6.89861   9.63845   1.000 23.19666 ? 69  PHE A CG  1 
ATOM   601  C  CD1 . PHE A 1 72  ? -34.19471 5.93038   10.60068  1.000 19.04287 ? 69  PHE A CD1 1 
ATOM   602  C  CD2 . PHE A 1 72  ? -32.59749 7.21032   9.34277   1.000 22.31850 ? 69  PHE A CD2 1 
ATOM   603  C  CE1 . PHE A 1 72  ? -33.16173 5.23610   11.22948  1.000 19.97730 ? 69  PHE A CE1 1 
ATOM   604  C  CE2 . PHE A 1 72  ? -31.54518 6.50746   9.97205   1.000 22.04805 ? 69  PHE A CE2 1 
ATOM   605  C  CZ  . PHE A 1 72  ? -31.84358 5.51515   10.92126  1.000 19.45787 ? 69  PHE A CZ  1 
ATOM   606  N  N   . GLU A 1 73  ? -34.05919 10.60641  9.54793   1.000 17.71380 ? 70  GLU A N   1 
ATOM   607  C  CA  . GLU A 1 73  ? -32.93513 11.45901  9.90034   1.000 21.65806 ? 70  GLU A CA  1 
ATOM   608  C  C   . GLU A 1 73  ? -33.22354 12.24063  11.17301  1.000 16.57346 ? 70  GLU A C   1 
ATOM   609  O  O   . GLU A 1 73  ? -32.31819 12.46404  11.97949  1.000 20.41686 ? 70  GLU A O   1 
ATOM   610  C  CB  . GLU A 1 73  ? -32.57555 12.39983  8.73902   1.000 20.67190 ? 70  GLU A CB  1 
ATOM   611  C  CG  . GLU A 1 73  ? -31.92596 11.64999  7.56246   1.000 24.05404 ? 70  GLU A CG  1 
ATOM   612  C  CD  . GLU A 1 73  ? -30.68111 10.84426  7.98609   1.000 34.81692 ? 70  GLU A CD  1 
ATOM   613  O  OE1 . GLU A 1 73  ? -29.75045 11.44601  8.57509   1.000 38.14293 ? 70  GLU A OE1 1 
ATOM   614  O  OE2 . GLU A 1 73  ? -30.63578 9.61416   7.74800   1.000 29.25051 ? 70  GLU A OE2 1 
ATOM   615  N  N   . TYR A 1 74  ? -34.47658 12.59455  11.40202  1.000 17.64013 ? 71  TYR A N   1 
ATOM   616  C  CA  . TYR A 1 74  ? -34.80582 13.43953  12.54026  1.000 15.75681 ? 71  TYR A CA  1 
ATOM   617  C  C   . TYR A 1 74  ? -35.07791 12.61940  13.80570  1.000 18.30009 ? 71  TYR A C   1 
ATOM   618  O  O   . TYR A 1 74  ? -34.63185 13.00583  14.88651  1.000 17.89646 ? 71  TYR A O   1 
ATOM   619  C  CB  . TYR A 1 74  ? -35.99788 14.35431  12.18154  1.000 19.69175 ? 71  TYR A CB  1 
ATOM   620  C  CG  . TYR A 1 74  ? -36.17055 15.52820  13.13129  1.000 19.02812 ? 71  TYR A CG  1 
ATOM   621  C  CD1 . TYR A 1 74  ? -35.17811 16.49742  13.24337  1.000 18.58813 ? 71  TYR A CD1 1 
ATOM   622  C  CD2 . TYR A 1 74  ? -37.33004 15.66853  13.90396  1.000 18.65267 ? 71  TYR A CD2 1 
ATOM   623  C  CE1 . TYR A 1 74  ? -35.30523 17.57163  14.11799  1.000 20.82733 ? 71  TYR A CE1 1 
ATOM   624  C  CE2 . TYR A 1 74  ? -37.47553 16.73956  14.79271  1.000 19.82137 ? 71  TYR A CE2 1 
ATOM   625  C  CZ  . TYR A 1 74  ? -36.45377 17.69132  14.88710  1.000 21.71456 ? 71  TYR A CZ  1 
ATOM   626  O  OH  . TYR A 1 74  ? -36.54693 18.74293  15.76654  1.000 18.93011 ? 71  TYR A OH  1 
ATOM   627  N  N   . TYR A 1 75  ? -35.75170 11.46856  13.69189  1.000 17.38846 ? 72  TYR A N   1 
ATOM   628  C  CA  . TYR A 1 75  ? -36.16453 10.68617  14.85445  1.000 15.68932 ? 72  TYR A CA  1 
ATOM   629  C  C   . TYR A 1 75  ? -35.36836 9.41005   15.09217  1.000 16.19814 ? 72  TYR A C   1 
ATOM   630  O  O   . TYR A 1 75  ? -35.49176 8.83283   16.17441  1.000 20.80525 ? 72  TYR A O   1 
ATOM   631  C  CB  . TYR A 1 75  ? -37.64481 10.27790  14.74282  1.000 18.49946 ? 72  TYR A CB  1 
ATOM   632  C  CG  . TYR A 1 75  ? -38.58601 11.44437  14.57572  1.000 19.43986 ? 72  TYR A CG  1 
ATOM   633  C  CD1 . TYR A 1 75  ? -38.88321 12.27156  15.64390  1.000 15.11616 ? 72  TYR A CD1 1 
ATOM   634  C  CD2 . TYR A 1 75  ? -39.18383 11.70600  13.35483  1.000 13.98690 ? 72  TYR A CD2 1 
ATOM   635  C  CE1 . TYR A 1 75  ? -39.74721 13.32789  15.49852  1.000 22.31340 ? 72  TYR A CE1 1 
ATOM   636  C  CE2 . TYR A 1 75  ? -40.04810 12.76975  13.19990  1.000 14.31873 ? 72  TYR A CE2 1 
ATOM   637  C  CZ  . TYR A 1 75  ? -40.32571 13.57184  14.28155  1.000 16.11208 ? 72  TYR A CZ  1 
ATOM   638  O  OH  . TYR A 1 75  ? -41.16294 14.64385  14.14686  1.000 21.12825 ? 72  TYR A OH  1 
ATOM   639  N  N   . HIS A 1 76  ? -34.62726 8.92076   14.10081  1.000 18.73989 ? 73  HIS A N   1 
ATOM   640  C  CA  . HIS A 1 76  ? -33.89402 7.65167   14.19380  1.000 21.77719 ? 73  HIS A CA  1 
ATOM   641  C  C   . HIS A 1 76  ? -34.81186 6.46409   14.47568  1.000 21.86565 ? 73  HIS A C   1 
ATOM   642  O  O   . HIS A 1 76  ? -34.46436 5.56437   15.23697  1.000 20.85261 ? 73  HIS A O   1 
ATOM   643  C  CB  . HIS A 1 76  ? -32.79197 7.72861   15.24558  1.000 20.85892 ? 73  HIS A CB  1 
ATOM   644  C  CG  . HIS A 1 76  ? -31.69827 8.67092   14.87428  1.000 22.69127 ? 73  HIS A CG  1 
ATOM   645  N  ND1 . HIS A 1 76  ? -30.56775 8.85232   15.64493  1.000 21.68206 ? 73  HIS A ND1 1 
ATOM   646  C  CD2 . HIS A 1 76  ? -31.55411 9.47083   13.79286  1.000 20.47855 ? 73  HIS A CD2 1 
ATOM   647  C  CE1 . HIS A 1 76  ? -29.78146 9.73722   15.05636  1.000 25.92848 ? 73  HIS A CE1 1 
ATOM   648  N  NE2 . HIS A 1 76  ? -30.36922 10.14365  13.94359  1.000 21.49680 ? 73  HIS A NE2 1 
ATOM   649  N  N   . THR A 1 77  ? -35.98083 6.45358   13.85406  1.000 19.29829 ? 74  THR A N   1 
ATOM   650  C  CA  . THR A 1 77  ? -36.88870 5.32082   13.92471  1.000 22.50116 ? 74  THR A CA  1 
ATOM   651  C  C   . THR A 1 77  ? -37.58755 5.19463   12.57779  1.000 21.43402 ? 74  THR A C   1 
ATOM   652  O  O   . THR A 1 77  ? -37.77055 6.19200   11.85766  1.000 20.66822 ? 74  THR A O   1 
ATOM   653  C  CB  . THR A 1 77  ? -37.93095 5.48937   15.05308  1.000 24.24615 ? 74  THR A CB  1 
ATOM   654  O  OG1 . THR A 1 77  ? -38.91332 4.44325   14.97129  1.000 24.19454 ? 74  THR A OG1 1 
ATOM   655  C  CG2 . THR A 1 77  ? -38.63866 6.83133   14.89169  1.000 23.02999 ? 74  THR A CG2 1 
ATOM   656  N  N   . THR A 1 78  ? -37.95243 3.95338   12.22152  1.000 19.70021 ? 75  THR A N   1 
ATOM   657  C  CA  . THR A 1 78  ? -38.84020 3.69161   11.09276  1.000 22.23505 ? 75  THR A CA  1 
ATOM   658  C  C   . THR A 1 78  ? -40.10426 2.95271   11.53531  1.000 21.42378 ? 75  THR A C   1 
ATOM   659  O  O   . THR A 1 78  ? -40.72204 2.23426   10.74587  1.000 19.35777 ? 75  THR A O   1 
ATOM   660  C  CB  . THR A 1 78  ? -38.12079 2.90645   9.98517   1.000 20.94082 ? 75  THR A CB  1 
ATOM   661  O  OG1 . THR A 1 78  ? -37.53749 1.70907   10.53141  1.000 18.78343 ? 75  THR A OG1 1 
ATOM   662  C  CG2 . THR A 1 78  ? -37.00447 3.75303   9.38025   1.000 20.83319 ? 75  THR A CG2 1 
ATOM   663  N  N   . ASP A 1 79  ? -40.48799 3.09772   12.79620  1.000 21.75352 ? 76  ASP A N   1 
ATOM   664  C  CA  . ASP A 1 79  ? -41.72636 2.49018   13.27637  1.000 19.79258 ? 76  ASP A CA  1 
ATOM   665  C  C   . ASP A 1 79  ? -42.89531 3.17644   12.59843  1.000 22.85974 ? 76  ASP A C   1 
ATOM   666  O  O   . ASP A 1 79  ? -43.02261 4.39923   12.72654  1.000 21.47826 ? 76  ASP A O   1 
ATOM   667  C  CB  . ASP A 1 79  ? -41.86669 2.65046   14.78477  1.000 15.52017 ? 76  ASP A CB  1 
ATOM   668  C  CG  . ASP A 1 79  ? -43.08645 1.91799   15.32694  1.000 26.64738 ? 76  ASP A CG  1 
ATOM   669  O  OD1 . ASP A 1 79  ? -43.52728 0.95335   14.68758  1.000 35.47470 ? 76  ASP A OD1 1 
ATOM   670  O  OD2 . ASP A 1 79  ? -43.58765 2.28755   16.38851  1.000 34.99900 ? 76  ASP A OD2 1 
ATOM   671  N  N   . PRO A 1 80  ? -43.76442 2.45684   11.88213  1.000 24.10370 ? 77  PRO A N   1 
ATOM   672  C  CA  . PRO A 1 80  ? -44.83390 3.14550   11.13116  1.000 28.41533 ? 77  PRO A CA  1 
ATOM   673  C  C   . PRO A 1 80  ? -45.74395 4.01555   11.98696  1.000 27.14737 ? 77  PRO A C   1 
ATOM   674  O  O   . PRO A 1 80  ? -46.22156 5.05762   11.50967  1.000 28.67333 ? 77  PRO A O   1 
ATOM   675  C  CB  . PRO A 1 80  ? -45.62165 1.98886   10.49741  1.000 25.20441 ? 77  PRO A CB  1 
ATOM   676  C  CG  . PRO A 1 80  ? -44.65917 0.84668   10.45019  1.000 29.10580 ? 77  PRO A CG  1 
ATOM   677  C  CD  . PRO A 1 80  ? -43.78075 0.99727   11.65993  1.000 27.72630 ? 77  PRO A CD  1 
ATOM   678  N  N   . SER A 1 81  ? -46.01668 3.62814   13.22696  1.000 22.85782 ? 78  SER A N   1 
ATOM   679  C  CA  . SER A 1 81  ? -46.96893 4.38249   14.04092  1.000 24.55987 ? 78  SER A CA  1 
ATOM   680  C  C   . SER A 1 81  ? -46.31591 5.48646   14.86160  1.000 25.77492 ? 78  SER A C   1 
ATOM   681  O  O   . SER A 1 81  ? -47.01259 6.16053   15.63064  1.000 25.74013 ? 78  SER A O   1 
ATOM   682  C  CB  . SER A 1 81  ? -47.74515 3.44303   14.95816  1.000 26.22043 ? 78  SER A CB  1 
ATOM   683  O  OG  . SER A 1 81  ? -46.87046 2.71229   15.78893  1.000 30.22319 ? 78  SER A OG  1 
ATOM   684  N  N   . PHE A 1 82  ? -45.01536 5.72499   14.68160  1.000 20.04654 ? 79  PHE A N   1 
ATOM   685  C  CA  . PHE A 1 82  ? -44.30144 6.64996   15.56224  1.000 25.14915 ? 79  PHE A CA  1 
ATOM   686  C  C   . PHE A 1 82  ? -44.91130 8.05281   15.54565  1.000 25.35945 ? 79  PHE A C   1 
ATOM   687  O  O   . PHE A 1 82  ? -45.26134 8.59551   16.59910  1.000 20.83490 ? 79  PHE A O   1 
ATOM   688  C  CB  . PHE A 1 82  ? -42.82366 6.73604   15.19741  1.000 18.87290 ? 79  PHE A CB  1 
ATOM   689  C  CG  . PHE A 1 82  ? -42.03748 7.60681   16.15186  1.000 19.88182 ? 79  PHE A CG  1 
ATOM   690  C  CD1 . PHE A 1 82  ? -41.50741 7.06281   17.33605  1.000 21.80482 ? 79  PHE A CD1 1 
ATOM   691  C  CD2 . PHE A 1 82  ? -41.85978 8.97101   15.89485  1.000 16.98161 ? 79  PHE A CD2 1 
ATOM   692  C  CE1 . PHE A 1 82  ? -40.79848 7.85310   18.24362  1.000 16.70205 ? 79  PHE A CE1 1 
ATOM   693  C  CE2 . PHE A 1 82  ? -41.15163 9.77946   16.81699  1.000 15.02276 ? 79  PHE A CE2 1 
ATOM   694  C  CZ  . PHE A 1 82  ? -40.61879 9.21301   17.97843  1.000 17.54080 ? 79  PHE A CZ  1 
ATOM   695  N  N   . LEU A 1 83  ? -45.01805 8.66776   14.36002  1.000 22.13482 ? 80  LEU A N   1 
ATOM   696  C  CA  . LEU A 1 83  ? -45.50546 10.04392  14.29711  1.000 27.26094 ? 80  LEU A CA  1 
ATOM   697  C  C   . LEU A 1 83  ? -46.91907 10.16223  14.84685  1.000 23.54007 ? 80  LEU A C   1 
ATOM   698  O  O   . LEU A 1 83  ? -47.23062 11.12004  15.56013  1.000 24.24124 ? 80  LEU A O   1 
ATOM   699  C  CB  . LEU A 1 83  ? -45.45325 10.56959  12.86935  1.000 23.05597 ? 80  LEU A CB  1 
ATOM   700  C  CG  . LEU A 1 83  ? -44.09525 11.08872  12.40728  1.000 27.61439 ? 80  LEU A CG  1 
ATOM   701  C  CD1 . LEU A 1 83  ? -44.21228 11.38948  10.94796  1.000 32.72709 ? 80  LEU A CD1 1 
ATOM   702  C  CD2 . LEU A 1 83  ? -43.74347 12.34653  13.15664  1.000 27.31947 ? 80  LEU A CD2 1 
ATOM   703  N  N   . GLY A 1 84  ? -47.77982 9.19492   14.53819  1.000 22.07632 ? 81  GLY A N   1 
ATOM   704  C  CA  . GLY A 1 84  ? -49.11524 9.18480   15.12489  1.000 23.72570 ? 81  GLY A CA  1 
ATOM   705  C  C   . GLY A 1 84  ? -49.09211 9.15052   16.64266  1.000 25.03347 ? 81  GLY A C   1 
ATOM   706  O  O   . GLY A 1 84  ? -49.80534 9.90646   17.30563  1.000 25.26119 ? 81  GLY A O   1 
ATOM   707  N  N   . ARG A 1 85  ? -48.25949 8.27642   17.21635  1.000 24.80036 ? 82  ARG A N   1 
ATOM   708  C  CA  . ARG A 1 85  ? -48.14898 8.19536   18.66894  1.000 22.35815 ? 82  ARG A CA  1 
ATOM   709  C  C   . ARG A 1 85  ? -47.52673 9.45782   19.25886  1.000 23.57855 ? 82  ARG A C   1 
ATOM   710  O  O   . ARG A 1 85  ? -47.94075 9.91789   20.32987  1.000 20.76182 ? 82  ARG A O   1 
ATOM   711  C  CB  . ARG A 1 85  ? -47.35147 6.94560   19.05631  1.000 25.50380 ? 82  ARG A CB  1 
ATOM   712  C  CG  . ARG A 1 85  ? -48.14762 5.68245   18.72432  1.000 27.10968 ? 82  ARG A CG  1 
ATOM   713  C  CD  . ARG A 1 85  ? -47.46700 4.37687   19.09241  1.000 29.59967 ? 82  ARG A CD  1 
ATOM   714  N  NE  . ARG A 1 85  ? -46.22313 4.14178   18.37320  1.000 33.37462 ? 82  ARG A NE  1 
ATOM   715  C  CZ  . ARG A 1 85  ? -45.03463 4.42274   18.88283  1.000 25.78112 ? 82  ARG A CZ  1 
ATOM   716  N  NH1 . ARG A 1 85  ? -44.92256 4.97648   20.07669  1.000 30.50763 ? 82  ARG A NH1 1 
ATOM   717  N  NH2 . ARG A 1 85  ? -43.93642 4.12279   18.18839  1.000 27.33726 ? 82  ARG A NH2 1 
ATOM   718  N  N   . TYR A 1 86  ? -46.56286 10.05446  18.55789  1.000 20.29725 ? 83  TYR A N   1 
ATOM   719  C  CA  . TYR A 1 86  ? -45.96808 11.30583  19.01967  1.000 20.25952 ? 83  TYR A CA  1 
ATOM   720  C  C   . TYR A 1 86  ? -46.98998 12.44698  18.98954  1.000 22.79458 ? 83  TYR A C   1 
ATOM   721  O  O   . TYR A 1 86  ? -47.08847 13.22864  19.95055  1.000 20.70849 ? 83  TYR A O   1 
ATOM   722  C  CB  . TYR A 1 86  ? -44.74598 11.61596  18.14907  1.000 19.59433 ? 83  TYR A CB  1 
ATOM   723  C  CG  . TYR A 1 86  ? -44.15124 12.99631  18.33210  1.000 19.61184 ? 83  TYR A CG  1 
ATOM   724  C  CD1 . TYR A 1 86  ? -44.02852 13.56476  19.59764  1.000 19.11805 ? 83  TYR A CD1 1 
ATOM   725  C  CD2 . TYR A 1 86  ? -43.65328 13.70711  17.24105  1.000 23.25365 ? 83  TYR A CD2 1 
ATOM   726  C  CE1 . TYR A 1 86  ? -43.45847 14.84092  19.76136  1.000 23.20951 ? 83  TYR A CE1 1 
ATOM   727  C  CE2 . TYR A 1 86  ? -43.08282 14.97906  17.39468  1.000 26.19047 ? 83  TYR A CE2 1 
ATOM   728  C  CZ  . TYR A 1 86  ? -43.00230 15.54358  18.65227  1.000 25.31410 ? 83  TYR A CZ  1 
ATOM   729  O  OH  . TYR A 1 86  ? -42.42577 16.79461  18.81187  1.000 26.91627 ? 83  TYR A OH  1 
ATOM   730  N  N   . MET A 1 87  ? -47.77213 12.55421  17.90267  1.000 19.92468 ? 84  MET A N   1 
ATOM   731  C  CA  . MET A 1 87  ? -48.80991 13.59363  17.85545  1.000 21.01556 ? 84  MET A CA  1 
ATOM   732  C  C   . MET A 1 87  ? -49.88170 13.36759  18.92502  1.000 22.70803 ? 84  MET A C   1 
ATOM   733  O  O   . MET A 1 87  ? -50.31620 14.31554  19.58887  1.000 21.35119 ? 84  MET A O   1 
ATOM   734  C  CB  . MET A 1 87  ? -49.44753 13.64535  16.46551  1.000 24.65163 ? 84  MET A CB  1 
ATOM   735  C  CG  . MET A 1 87  ? -48.54857 14.27341  15.39491  1.000 22.26904 ? 84  MET A CG  1 
ATOM   736  S  SD  . MET A 1 87  ? -48.13669 15.98735  15.74531  1.000 24.49010 ? 84  MET A SD  1 
ATOM   737  C  CE  . MET A 1 87  ? -46.43224 15.89501  16.28341  1.000 22.39291 ? 84  MET A CE  1 
ATOM   738  N  N   . SER A 1 88  ? -50.31638 12.11866  19.11064  1.000 19.31558 ? 85  SER A N   1 
ATOM   739  C  CA  . SER A 1 88  ? -51.34959 11.83308  20.10394  1.000 23.88026 ? 85  SER A CA  1 
ATOM   740  C  C   . SER A 1 88  ? -50.89755 12.24429  21.49334  1.000 24.30284 ? 85  SER A C   1 
ATOM   741  O  O   . SER A 1 88  ? -51.66249 12.83524  22.25184  1.000 23.81438 ? 85  SER A O   1 
ATOM   742  C  CB  . SER A 1 88  ? -51.71642 10.35349  20.09091  1.000 27.11099 ? 85  SER A CB  1 
ATOM   743  O  OG  . SER A 1 88  ? -52.18554 9.97551   18.81250  1.000 32.25172 ? 85  SER A OG  1 
ATOM   744  N  N   . ALA A 1 89  ? -49.66056 11.90558  21.85672  1.000 19.80174 ? 86  ALA A N   1 
ATOM   745  C  CA  . ALA A 1 89  ? -49.11558 12.36711  23.12462  1.000 22.98013 ? 86  ALA A CA  1 
ATOM   746  C  C   . ALA A 1 89  ? -49.03317 13.89336  23.16784  1.000 22.77532 ? 86  ALA A C   1 
ATOM   747  O  O   . ALA A 1 89  ? -49.40189 14.52296  24.17457  1.000 23.49320 ? 86  ALA A O   1 
ATOM   748  C  CB  . ALA A 1 89  ? -47.73604 11.73877  23.34082  1.000 21.09804 ? 86  ALA A CB  1 
ATOM   749  N  N   . LEU A 1 90  ? -48.50469 14.50489  22.09609  1.000 19.06551 ? 87  LEU A N   1 
ATOM   750  C  CA  . LEU A 1 90  ? -48.27407 15.94925  22.10340  1.000 20.30792 ? 87  LEU A CA  1 
ATOM   751  C  C   . LEU A 1 90  ? -49.57471 16.71271  22.33728  1.000 22.29634 ? 87  LEU A C   1 
ATOM   752  O  O   . LEU A 1 90  ? -49.59625 17.73327  23.03371  1.000 18.57943 ? 87  LEU A O   1 
ATOM   753  C  CB  . LEU A 1 90  ? -47.61338 16.39121  20.78735  1.000 19.44083 ? 87  LEU A CB  1 
ATOM   754  C  CG  . LEU A 1 90  ? -47.31119 17.89405  20.68846  1.000 17.57334 ? 87  LEU A CG  1 
ATOM   755  C  CD1 . LEU A 1 90  ? -46.37431 18.32291  21.78629  1.000 23.51562 ? 87  LEU A CD1 1 
ATOM   756  C  CD2 . LEU A 1 90  ? -46.73364 18.27554  19.31376  1.000 23.29055 ? 87  LEU A CD2 1 
ATOM   757  N  N   . ASN A 1 91  ? -50.67609 16.21844  21.78190  1.000 19.84497 ? 88  ASN A N   1 
ATOM   758  C  CA  . ASN A 1 91  ? -51.96171 16.86232  22.01146  1.000 24.42840 ? 88  ASN A CA  1 
ATOM   759  C  C   . ASN A 1 91  ? -52.27456 16.97004  23.49763  1.000 24.56645 ? 88  ASN A C   1 
ATOM   760  O  O   . ASN A 1 91  ? -52.98193 17.89231  23.91814  1.000 27.81361 ? 88  ASN A O   1 
ATOM   761  C  CB  . ASN A 1 91  ? -53.06036 16.08660  21.30170  1.000 22.28437 ? 88  ASN A CB  1 
ATOM   762  C  CG  . ASN A 1 91  ? -54.26451 16.92892  21.05028  1.000 27.95883 ? 88  ASN A CG  1 
ATOM   763  O  OD1 . ASN A 1 91  ? -54.14596 18.10366  20.70357  1.000 27.87841 ? 88  ASN A OD1 1 
ATOM   764  N  ND2 . ASN A 1 91  ? -55.43297 16.35572  21.25543  1.000 31.42236 ? 88  ASN A ND2 1 
ATOM   765  N  N   . HIS A 1 92  ? -51.76399 16.03662  24.30498  1.000 19.62252 ? 89  HIS A N   1 
ATOM   766  C  CA  . HIS A 1 92  ? -51.90251 16.11234  25.74644  1.000 20.30314 ? 89  HIS A CA  1 
ATOM   767  C  C   . HIS A 1 92  ? -50.78435 16.91770  26.40049  1.000 17.31923 ? 89  HIS A C   1 
ATOM   768  O  O   . HIS A 1 92  ? -51.05194 17.78870  27.23585  1.000 22.62428 ? 89  HIS A O   1 
ATOM   769  C  CB  . HIS A 1 92  ? -51.92298 14.70946  26.33991  1.000 22.32741 ? 89  HIS A CB  1 
ATOM   770  C  CG  . HIS A 1 92  ? -53.11633 13.90252  25.95322  1.000 23.29257 ? 89  HIS A CG  1 
ATOM   771  N  ND1 . HIS A 1 92  ? -54.30271 13.96183  26.64491  1.000 25.12839 ? 89  HIS A ND1 1 
ATOM   772  C  CD2 . HIS A 1 92  ? -53.29709 12.98856  24.97282  1.000 27.34147 ? 89  HIS A CD2 1 
ATOM   773  C  CE1 . HIS A 1 92  ? -55.17609 13.13890  26.09156  1.000 27.15349 ? 89  HIS A CE1 1 
ATOM   774  N  NE2 . HIS A 1 92  ? -54.58788 12.52775  25.08056  1.000 25.85706 ? 89  HIS A NE2 1 
ATOM   775  N  N   . THR A 1 93  ? -49.52207 16.62029  26.06873  1.000 19.78036 ? 90  THR A N   1 
ATOM   776  C  CA  . THR A 1 93  ? -48.43864 17.23115  26.82647  1.000 17.96768 ? 90  THR A CA  1 
ATOM   777  C  C   . THR A 1 93  ? -48.34395 18.72826  26.58303  1.000 16.76992 ? 90  THR A C   1 
ATOM   778  O  O   . THR A 1 93  ? -47.76282 19.43585  27.41319  1.000 21.03035 ? 90  THR A O   1 
ATOM   779  C  CB  . THR A 1 93  ? -47.08026 16.60433  26.50326  1.000 19.32857 ? 90  THR A CB  1 
ATOM   780  O  OG1 . THR A 1 93  ? -46.73859 16.87899  25.14466  1.000 18.02163 ? 90  THR A OG1 1 
ATOM   781  C  CG2 . THR A 1 93  ? -47.06740 15.08549  26.76676  1.000 13.47607 ? 90  THR A CG2 1 
ATOM   782  N  N   . LYS A 1 94  ? -48.86123 19.22648  25.45747  1.000 20.23858 ? 91  LYS A N   1 
ATOM   783  C  CA  . LYS A 1 94  ? -48.83189 20.67434  25.26002  1.000 21.79514 ? 91  LYS A CA  1 
ATOM   784  C  C   . LYS A 1 94  ? -49.75698 21.39262  26.23007  1.000 24.09786 ? 91  LYS A C   1 
ATOM   785  O  O   . LYS A 1 94  ? -49.62870 22.61282  26.40662  1.000 22.50921 ? 91  LYS A O   1 
ATOM   786  C  CB  . LYS A 1 94  ? -49.19530 21.03239  23.81760  1.000 20.36515 ? 91  LYS A CB  1 
ATOM   787  C  CG  . LYS A 1 94  ? -50.64117 20.82421  23.47435  1.000 27.36187 ? 91  LYS A CG  1 
ATOM   788  C  CD  . LYS A 1 94  ? -50.91298 21.01143  21.97396  1.000 34.35328 ? 91  LYS A CD  1 
ATOM   789  C  CE  . LYS A 1 94  ? -52.42782 20.81990  21.69635  1.000 34.62403 ? 91  LYS A CE  1 
ATOM   790  N  NZ  . LYS A 1 94  ? -52.79247 20.93532  20.26184  1.000 33.80092 ? 91  LYS A NZ  1 
ATOM   791  N  N   . LYS A 1 95  ? -50.64961 20.65826  26.88528  1.000 19.72083 ? 92  LYS A N   1 
ATOM   792  C  CA  . LYS A 1 95  ? -51.52393 21.20204  27.91550  1.000 24.27488 ? 92  LYS A CA  1 
ATOM   793  C  C   . LYS A 1 95  ? -51.00581 20.97249  29.33097  1.000 28.22202 ? 92  LYS A C   1 
ATOM   794  O  O   . LYS A 1 95  ? -51.55541 21.53644  30.27410  1.000 22.71622 ? 92  LYS A O   1 
ATOM   795  C  CB  . LYS A 1 95  ? -52.91897 20.59668  27.77380  1.000 25.37780 ? 92  LYS A CB  1 
ATOM   796  C  CG  . LYS A 1 95  ? -53.60369 20.96985  26.46959  1.000 28.96069 ? 92  LYS A CG  1 
ATOM   797  C  CD  . LYS A 1 95  ? -54.89053 20.19574  26.30647  1.000 38.78437 ? 92  LYS A CD  1 
ATOM   798  C  CE  . LYS A 1 95  ? -55.57219 20.53806  24.98409  1.000 48.77557 ? 92  LYS A CE  1 
ATOM   799  N  NZ  . LYS A 1 95  ? -56.27946 19.33531  24.43012  1.000 51.94732 ? 92  LYS A NZ  1 
ATOM   800  N  N   . TRP A 1 96  ? -49.97985 20.15106  29.50718  1.000 23.65386 ? 93  TRP A N   1 
ATOM   801  C  CA  . TRP A 1 96  ? -49.33082 20.04991  30.79904  1.000 20.08985 ? 93  TRP A CA  1 
ATOM   802  C  C   . TRP A 1 96  ? -48.61627 21.35569  31.14233  1.000 22.50669 ? 93  TRP A C   1 
ATOM   803  O  O   . TRP A 1 96  ? -48.31888 22.17048  30.26560  1.000 22.38469 ? 93  TRP A O   1 
ATOM   804  C  CB  . TRP A 1 96  ? -48.32051 18.90965  30.78934  1.000 18.06594 ? 93  TRP A CB  1 
ATOM   805  C  CG  . TRP A 1 96  ? -48.92027 17.56232  30.63392  1.000 20.73065 ? 93  TRP A CG  1 
ATOM   806  C  CD1 . TRP A 1 96  ? -50.25177 17.23691  30.63148  1.000 19.15285 ? 93  TRP A CD1 1 
ATOM   807  C  CD2 . TRP A 1 96  ? -48.19861 16.32652  30.49175  1.000 18.36560 ? 93  TRP A CD2 1 
ATOM   808  N  NE1 . TRP A 1 96  ? -50.39836 15.87309  30.47418  1.000 20.84482 ? 93  TRP A NE1 1 
ATOM   809  C  CE2 . TRP A 1 96  ? -49.15466 15.29105  30.40062  1.000 22.99157 ? 93  TRP A CE2 1 
ATOM   810  C  CE3 . TRP A 1 96  ? -46.83823 15.99489  30.47240  1.000 20.06095 ? 93  TRP A CE3 1 
ATOM   811  C  CZ2 . TRP A 1 96  ? -48.79298 13.94307  30.26928  1.000 18.10703 ? 93  TRP A CZ2 1 
ATOM   812  C  CZ3 . TRP A 1 96  ? -46.47488 14.63611  30.32645  1.000 16.33716 ? 93  TRP A CZ3 1 
ATOM   813  C  CH2 . TRP A 1 96  ? -47.45203 13.64033  30.22842  1.000 20.41009 ? 93  TRP A CH2 1 
ATOM   814  N  N   . LYS A 1 97  ? -48.32766 21.53642  32.43832  1.000 21.07578 ? 94  LYS A N   1 
ATOM   815  C  CA  . LYS A 1 97  ? -47.54243 22.65195  32.94792  1.000 22.54545 ? 94  LYS A CA  1 
ATOM   816  C  C   . LYS A 1 97  ? -46.15243 22.17378  33.34232  1.000 21.43953 ? 94  LYS A C   1 
ATOM   817  O  O   . LYS A 1 97  ? -46.00519 21.10148  33.92314  1.000 21.26276 ? 94  LYS A O   1 
ATOM   818  C  CB  . LYS A 1 97  ? -48.19513 23.29747  34.17875  1.000 19.95429 ? 94  LYS A CB  1 
ATOM   819  C  CG  . LYS A 1 97  ? -49.60544 23.80349  33.91552  1.000 29.58870 ? 94  LYS A CG  1 
ATOM   820  C  CD  . LYS A 1 97  ? -49.56860 24.80337  32.76747  1.000 36.85529 ? 94  LYS A CD  1 
ATOM   821  C  CE  . LYS A 1 97  ? -50.92814 25.44730  32.53945  1.000 48.31897 ? 94  LYS A CE  1 
ATOM   822  N  NZ  . LYS A 1 97  ? -50.81766 26.49449  31.47342  1.000 56.54480 ? 94  LYS A NZ  1 
ATOM   823  N  N   . TYR A 1 98  ? -45.14708 23.00433  33.07351  1.000 19.45474 ? 95  TYR A N   1 
ATOM   824  C  CA  . TYR A 1 98  ? -43.74188 22.67724  33.31503  1.000 20.89982 ? 95  TYR A CA  1 
ATOM   825  C  C   . TYR A 1 98  ? -43.12567 23.74773  34.21020  1.000 24.65519 ? 95  TYR A C   1 
ATOM   826  O  O   . TYR A 1 98  ? -42.37244 24.62206  33.74833  1.000 22.05327 ? 95  TYR A O   1 
ATOM   827  C  CB  . TYR A 1 98  ? -42.98175 22.53652  31.99735  1.000 20.51682 ? 95  TYR A CB  1 
ATOM   828  C  CG  . TYR A 1 98  ? -43.66532 21.54197  31.09450  1.000 18.41288 ? 95  TYR A CG  1 
ATOM   829  C  CD1 . TYR A 1 98  ? -43.40432 20.17693  31.21739  1.000 17.72675 ? 95  TYR A CD1 1 
ATOM   830  C  CD2 . TYR A 1 98  ? -44.58375 21.95843  30.14087  1.000 17.36750 ? 95  TYR A CD2 1 
ATOM   831  C  CE1 . TYR A 1 98  ? -44.02495 19.25073  30.40081  1.000 19.64078 ? 95  TYR A CE1 1 
ATOM   832  C  CE2 . TYR A 1 98  ? -45.20513 21.03307  29.29890  1.000 18.08234 ? 95  TYR A CE2 1 
ATOM   833  C  CZ  . TYR A 1 98  ? -44.93152 19.67795  29.44934  1.000 17.29377 ? 95  TYR A CZ  1 
ATOM   834  O  OH  . TYR A 1 98  ? -45.56347 18.74810  28.65376  1.000 17.73120 ? 95  TYR A OH  1 
ATOM   835  N  N   . PRO A 1 99  ? -43.43927 23.71517  35.50013  1.000 19.18814 ? 96  PRO A N   1 
ATOM   836  C  CA  . PRO A 1 99  ? -42.86110 24.69728  36.42055  1.000 21.68845 ? 96  PRO A CA  1 
ATOM   837  C  C   . PRO A 1 99  ? -41.38146 24.44487  36.63783  1.000 21.05660 ? 96  PRO A C   1 
ATOM   838  O  O   . PRO A 1 99  ? -40.90698 23.30441  36.58555  1.000 21.69826 ? 96  PRO A O   1 
ATOM   839  C  CB  . PRO A 1 99  ? -43.65087 24.47366  37.71529  1.000 19.89604 ? 96  PRO A CB  1 
ATOM   840  C  CG  . PRO A 1 99  ? -44.00957 22.98998  37.64967  1.000 19.57875 ? 96  PRO A CG  1 
ATOM   841  C  CD  . PRO A 1 99  ? -44.29020 22.72594  36.18839  1.000 21.21979 ? 96  PRO A CD  1 
ATOM   842  N  N   . GLN A 1 100 ? -40.64786 25.53661  36.86668  1.000 23.55232 ? 97  GLN A N   1 
ATOM   843  C  CA  . GLN A 1 100 ? -39.25972 25.45374  37.31251  1.000 20.74207 ? 97  GLN A CA  1 
ATOM   844  C  C   . GLN A 1 100 ? -39.24275 25.19003  38.81358  1.000 20.03232 ? 97  GLN A C   1 
ATOM   845  O  O   . GLN A 1 100 ? -39.74828 26.00019  39.59775  1.000 18.89665 ? 97  GLN A O   1 
ATOM   846  C  CB  . GLN A 1 100 ? -38.51925 26.75852  37.01911  1.000 19.80862 ? 97  GLN A CB  1 
ATOM   847  C  CG  . GLN A 1 100 ? -38.40540 27.10821  35.56473  1.000 23.37718 ? 97  GLN A CG  1 
ATOM   848  C  CD  . GLN A 1 100 ? -37.53484 26.12682  34.83105  1.000 26.94951 ? 97  GLN A CD  1 
ATOM   849  O  OE1 . GLN A 1 100 ? -36.37062 25.94286  35.17557  1.000 26.91310 ? 97  GLN A OE1 1 
ATOM   850  N  NE2 . GLN A 1 100 ? -38.10199 25.46870  33.83443  1.000 24.21605 ? 97  GLN A NE2 1 
ATOM   851  N  N   . VAL A 1 101 ? -38.65520 24.08206  39.22534  1.000 18.94825 ? 98  VAL A N   1 
ATOM   852  C  CA  . VAL A 1 101 ? -38.59880 23.73651  40.62811  1.000 15.72303 ? 98  VAL A CA  1 
ATOM   853  C  C   . VAL A 1 101 ? -37.14139 23.57181  40.99292  1.000 18.87614 ? 98  VAL A C   1 
ATOM   854  O  O   . VAL A 1 101 ? -36.45079 22.72204  40.41698  1.000 16.91513 ? 98  VAL A O   1 
ATOM   855  C  CB  . VAL A 1 101 ? -39.38955 22.45927  40.94964  1.000 19.34304 ? 98  VAL A CB  1 
ATOM   856  C  CG1 . VAL A 1 101 ? -39.32465 22.19773  42.43925  1.000 15.18500 ? 98  VAL A CG1 1 
ATOM   857  C  CG2 . VAL A 1 101 ? -40.82532 22.58844  40.47603  1.000 17.98311 ? 98  VAL A CG2 1 
ATOM   858  N  N   . ASN A 1 102 ? -36.68559 24.36835  41.96357  1.000 19.75096 ? 99  ASN A N   1 
ATOM   859  C  CA  . ASN A 1 102 ? -35.27924 24.42449  42.34086  1.000 22.51152 ? 99  ASN A CA  1 
ATOM   860  C  C   . ASN A 1 102 ? -34.35997 24.53454  41.12413  1.000 21.89649 ? 99  ASN A C   1 
ATOM   861  O  O   . ASN A 1 102 ? -33.30679 23.89224  41.05152  1.000 18.58591 ? 99  ASN A O   1 
ATOM   862  C  CB  . ASN A 1 102 ? -34.88123 23.21950  43.18649  1.000 22.09499 ? 99  ASN A CB  1 
ATOM   863  C  CG  . ASN A 1 102 ? -33.61281 23.47638  43.95018  1.000 27.64513 ? 99  ASN A CG  1 
ATOM   864  O  OD1 . ASN A 1 102 ? -33.44847 24.54361  44.54142  1.000 24.12629 ? 99  ASN A OD1 1 
ATOM   865  N  ND2 . ASN A 1 102 ? -32.67592 22.53765  43.88400  1.000 28.54099 ? 99  ASN A ND2 1 
ATOM   866  N  N   . GLY A 1 103 ? -34.76280 25.34589  40.15881  1.000 20.81862 ? 100 GLY A N   1 
ATOM   867  C  CA  . GLY A 1 103 ? -33.94103 25.61933  39.00304  1.000 24.79049 ? 100 GLY A CA  1 
ATOM   868  C  C   . GLY A 1 103 ? -34.03321 24.60319  37.87788  1.000 23.78781 ? 100 GLY A C   1 
ATOM   869  O  O   . GLY A 1 103 ? -33.31435 24.75098  36.89093  1.000 23.62303 ? 100 GLY A O   1 
ATOM   870  N  N   . LEU A 1 104 ? -34.87733 23.57804  38.00566  1.000 21.75620 ? 101 LEU A N   1 
ATOM   871  C  CA  . LEU A 1 104 ? -35.00737 22.51638  37.01406  1.000 18.04526 ? 101 LEU A CA  1 
ATOM   872  C  C   . LEU A 1 104 ? -36.41267 22.52883  36.43587  1.000 19.43119 ? 101 LEU A C   1 
ATOM   873  O  O   . LEU A 1 104 ? -37.38331 22.85814  37.12893  1.000 24.41133 ? 101 LEU A O   1 
ATOM   874  C  CB  . LEU A 1 104 ? -34.73121 21.12741  37.62690  1.000 19.32569 ? 101 LEU A CB  1 
ATOM   875  C  CG  . LEU A 1 104 ? -33.34801 20.95046  38.25085  1.000 22.98807 ? 101 LEU A CG  1 
ATOM   876  C  CD1 . LEU A 1 104 ? -33.21389 19.60813  38.95529  1.000 22.69669 ? 101 LEU A CD1 1 
ATOM   877  C  CD2 . LEU A 1 104 ? -32.31917 21.09208  37.16702  1.000 19.53771 ? 101 LEU A CD2 1 
ATOM   878  N  N   . THR A 1 105 ? -36.52687 22.14608  35.17163  1.000 20.09278 ? 102 THR A N   1 
ATOM   879  C  CA  . THR A 1 105 ? -37.84971 21.98557  34.57894  1.000 22.86092 ? 102 THR A CA  1 
ATOM   880  C  C   . THR A 1 105 ? -38.48896 20.70458  35.11299  1.000 22.50417 ? 102 THR A C   1 
ATOM   881  O  O   . THR A 1 105 ? -37.94232 19.60899  34.94425  1.000 18.32179 ? 102 THR A O   1 
ATOM   882  C  CB  . THR A 1 105 ? -37.73906 21.94919  33.05825  1.000 24.78315 ? 102 THR A CB  1 
ATOM   883  O  OG1 . THR A 1 105 ? -37.02850 23.11767  32.61176  1.000 24.02894 ? 102 THR A OG1 1 
ATOM   884  C  CG2 . THR A 1 105 ? -39.11669 21.89503  32.40186  1.000 17.69442 ? 102 THR A CG2 1 
ATOM   885  N  N   . SER A 1 106 ? -39.64976 20.83821  35.74621  1.000 17.04743 ? 103 SER A N   1 
ATOM   886  C  CA  . SER A 1 106 ? -40.41764 19.69277  36.20058  1.000 17.88498 ? 103 SER A CA  1 
ATOM   887  C  C   . SER A 1 106 ? -41.71943 19.62419  35.40615  1.000 16.23348 ? 103 SER A C   1 
ATOM   888  O  O   . SER A 1 106 ? -41.86685 20.29981  34.37795  1.000 22.90079 ? 103 SER A O   1 
ATOM   889  C  CB  . SER A 1 106 ? -40.66014 19.80703  37.71133  1.000 17.25795 ? 103 SER A CB  1 
ATOM   890  O  OG  . SER A 1 106 ? -41.16456 18.57971  38.21723  1.000 18.92107 ? 103 SER A OG  1 
ATOM   891  N  N   . ILE A 1 107 ? -42.67584 18.83525  35.89423  1.000 16.38251 ? 104 ILE A N   1 
ATOM   892  C  CA  . ILE A 1 107 ? -43.96268 18.69383  35.23238  1.000 17.84501 ? 104 ILE A CA  1 
ATOM   893  C  C   . ILE A 1 107 ? -45.03516 18.65276  36.30477  1.000 20.03775 ? 104 ILE A C   1 
ATOM   894  O  O   . ILE A 1 107 ? -44.97344 17.81286  37.20914  1.000 18.31769 ? 104 ILE A O   1 
ATOM   895  C  CB  . ILE A 1 107 ? -44.08170 17.41535  34.37165  1.000 17.98930 ? 104 ILE A CB  1 
ATOM   896  C  CG1 . ILE A 1 107 ? -42.81529 17.11165  33.56954  1.000 19.04495 ? 104 ILE A CG1 1 
ATOM   897  C  CG2 . ILE A 1 107 ? -45.28592 17.53678  33.42225  1.000 17.36083 ? 104 ILE A CG2 1 
ATOM   898  C  CD1 . ILE A 1 107 ? -42.88013 15.74509  32.84747  1.000 18.36587 ? 104 ILE A CD1 1 
ATOM   899  N  N   . LYS A 1 108 ? -46.04096 19.51314  36.18157  1.000 18.02994 ? 105 LYS A N   1 
ATOM   900  C  CA  . LYS A 1 108 ? -47.18301 19.42009  37.08496  1.000 20.98254 ? 105 LYS A CA  1 
ATOM   901  C  C   . LYS A 1 108 ? -47.90262 18.10230  36.85066  1.000 15.62907 ? 105 LYS A C   1 
ATOM   902  O  O   . LYS A 1 108 ? -48.04206 17.65323  35.70976  1.000 25.34749 ? 105 LYS A O   1 
ATOM   903  C  CB  . LYS A 1 108 ? -48.12794 20.59534  36.87364  1.000 24.61932 ? 105 LYS A CB  1 
ATOM   904  C  CG  . LYS A 1 108 ? -49.31950 20.64816  37.85167  1.000 24.52370 ? 105 LYS A CG  1 
ATOM   905  C  CD  . LYS A 1 108 ? -50.27184 21.77611  37.42404  1.000 27.92360 ? 105 LYS A CD  1 
ATOM   906  C  CE  . LYS A 1 108 ? -51.67603 21.61788  38.02747  1.000 41.71106 ? 105 LYS A CE  1 
ATOM   907  N  NZ  . LYS A 1 108 ? -52.69303 22.18927  37.08467  1.000 48.29334 ? 105 LYS A NZ  1 
ATOM   908  N  N   . TRP A 1 109 ? -48.32933 17.45687  37.93468  1.000 22.32583 ? 106 TRP A N   1 
ATOM   909  C  CA  . TRP A 1 109 ? -48.88000 16.11516  37.79792  1.000 23.34229 ? 106 TRP A CA  1 
ATOM   910  C  C   . TRP A 1 109 ? -50.15026 16.12501  36.94632  1.000 28.50140 ? 106 TRP A C   1 
ATOM   911  O  O   . TRP A 1 109 ? -51.03110 16.97412  37.10645  1.000 24.01078 ? 106 TRP A O   1 
ATOM   912  C  CB  . TRP A 1 109 ? -49.16927 15.47313  39.16113  1.000 27.19182 ? 106 TRP A CB  1 
ATOM   913  C  CG  . TRP A 1 109 ? -49.56889 14.03964  38.95440  1.000 28.59412 ? 106 TRP A CG  1 
ATOM   914  C  CD1 . TRP A 1 109 ? -48.73535 12.93698  38.89084  1.000 27.45164 ? 106 TRP A CD1 1 
ATOM   915  C  CD2 . TRP A 1 109 ? -50.88545 13.56309  38.68582  1.000 25.76521 ? 106 TRP A CD2 1 
ATOM   916  N  NE1 . TRP A 1 109 ? -49.47640 11.80449  38.62213  1.000 28.71320 ? 106 TRP A NE1 1 
ATOM   917  C  CE2 . TRP A 1 109 ? -50.79734 12.16327  38.49078  1.000 29.49192 ? 106 TRP A CE2 1 
ATOM   918  C  CE3 . TRP A 1 109 ? -52.13940 14.18071  38.59928  1.000 30.44800 ? 106 TRP A CE3 1 
ATOM   919  C  CZ2 . TRP A 1 109 ? -51.92243 11.37505  38.22472  1.000 28.95441 ? 106 TRP A CZ2 1 
ATOM   920  C  CZ3 . TRP A 1 109 ? -53.26244 13.38389  38.32312  1.000 30.88669 ? 106 TRP A CZ3 1 
ATOM   921  C  CH2 . TRP A 1 109 ? -53.13544 12.00453  38.13772  1.000 28.33702 ? 106 TRP A CH2 1 
ATOM   922  N  N   . ALA A 1 110 ? -50.22554 15.16367  36.03576  1.000 19.97698 ? 107 ALA A N   1 
ATOM   923  C  CA  . ALA A 1 110 ? -51.38015 14.89943  35.19426  1.000 24.35773 ? 107 ALA A CA  1 
ATOM   924  C  C   . ALA A 1 110 ? -51.13787 13.53553  34.59029  1.000 24.09226 ? 107 ALA A C   1 
ATOM   925  O  O   . ALA A 1 110 ? -49.99093 13.17151  34.33784  1.000 22.70103 ? 107 ALA A O   1 
ATOM   926  C  CB  . ALA A 1 110 ? -51.54797 15.93817  34.07425  1.000 22.01882 ? 107 ALA A CB  1 
ATOM   927  N  N   . ASP A 1 111 ? -52.20566 12.78444  34.35439  1.000 21.55116 ? 108 ASP A N   1 
ATOM   928  C  CA  . ASP A 1 111 ? -52.11949 11.67669  33.40107  1.000 21.80069 ? 108 ASP A CA  1 
ATOM   929  C  C   . ASP A 1 111 ? -51.03655 10.66815  33.78692  1.000 28.71185 ? 108 ASP A C   1 
ATOM   930  O  O   . ASP A 1 111 ? -50.32325 10.15080  32.92430  1.000 27.29399 ? 108 ASP A O   1 
ATOM   931  C  CB  . ASP A 1 111 ? -51.83715 12.21328  31.98802  1.000 19.23248 ? 108 ASP A CB  1 
ATOM   932  C  CG  . ASP A 1 111 ? -52.97010 13.07514  31.43270  1.000 27.40762 ? 108 ASP A CG  1 
ATOM   933  O  OD1 . ASP A 1 111 ? -54.12282 12.64527  31.60929  1.000 30.57989 ? 108 ASP A OD1 1 
ATOM   934  O  OD2 . ASP A 1 111 ? -52.71133 14.14213  30.79732  1.000 23.59968 ? 108 ASP A OD2 1 
ATOM   935  N  N   . ASN A 1 112 ? -50.88230 10.40913  35.08191  1.000 25.57090 ? 109 ASN A N   1 
ATOM   936  C  CA  . ASN A 1 112 ? -49.85348 9.47870   35.57002  1.000 25.19581 ? 109 ASN A CA  1 
ATOM   937  C  C   . ASN A 1 112 ? -48.45425 9.82366   35.05220  1.000 24.10996 ? 109 ASN A C   1 
ATOM   938  O  O   . ASN A 1 112 ? -47.62941 8.93775   34.83310  1.000 25.35722 ? 109 ASN A O   1 
ATOM   939  C  CB  . ASN A 1 112 ? -50.19180 8.03039   35.20043  1.000 28.87043 ? 109 ASN A CB  1 
ATOM   940  C  CG  . ASN A 1 112 ? -51.39149 7.50665   35.92848  1.000 38.85724 ? 109 ASN A CG  1 
ATOM   941  O  OD1 . ASN A 1 112 ? -51.66412 7.89520   37.06271  1.000 42.67018 ? 109 ASN A OD1 1 
ATOM   942  N  ND2 . ASN A 1 112 ? -52.12825 6.61155   35.27879  1.000 40.06686 ? 109 ASN A ND2 1 
ATOM   943  N  N   . ASN A 1 113 ? -48.14861 11.11571  34.89385  1.000 19.97904 ? 110 ASN A N   1 
ATOM   944  C  CA  . ASN A 1 113 ? -46.85592 11.48946  34.31700  1.000 18.48528 ? 110 ASN A CA  1 
ATOM   945  C  C   . ASN A 1 113 ? -45.73406 11.61662  35.34977  1.000 22.88004 ? 110 ASN A C   1 
ATOM   946  O  O   . ASN A 1 113 ? -44.68308 12.18084  35.02906  1.000 19.94936 ? 110 ASN A O   1 
ATOM   947  C  CB  . ASN A 1 113 ? -46.96385 12.80280  33.52074  1.000 20.94996 ? 110 ASN A CB  1 
ATOM   948  C  CG  . ASN A 1 113 ? -47.29328 14.00168  34.39079  1.000 21.82821 ? 110 ASN A CG  1 
ATOM   949  O  OD1 . ASN A 1 113 ? -47.36845 13.89771  35.61445  1.000 20.70666 ? 110 ASN A OD1 1 
ATOM   950  N  ND2 . ASN A 1 113 ? -47.49360 15.16552  33.75089  1.000 17.08450 ? 110 ASN A ND2 1 
ATOM   951  N  N   . CYS A 1 114 ? -45.92018 11.10089  36.56583  1.000 20.43606 ? 111 CYS A N   1 
ATOM   952  C  CA  . CYS A 1 114 ? -44.87881 11.22920  37.59506  1.000 23.46743 ? 111 CYS A CA  1 
ATOM   953  C  C   . CYS A 1 114 ? -43.56411 10.58960  37.15710  1.000 23.91480 ? 111 CYS A C   1 
ATOM   954  O  O   . CYS A 1 114 ? -42.48081 11.10942  37.46049  1.000 19.94647 ? 111 CYS A O   1 
ATOM   955  C  CB  . CYS A 1 114 ? -45.34864 10.60587  38.90535  1.000 18.93963 ? 111 CYS A CB  1 
ATOM   956  S  SG  . CYS A 1 114 ? -45.87288 8.87539   38.72494  1.000 26.73741 ? 111 CYS A SG  1 
ATOM   957  N  N   . TYR A 1 115 ? -43.62888 9.45389   36.45120  1.000 18.16453 ? 112 TYR A N   1 
ATOM   958  C  CA  . TYR A 1 115 ? -42.37881 8.83141   36.01482  1.000 20.49673 ? 112 TYR A CA  1 
ATOM   959  C  C   . TYR A 1 115 ? -41.64428 9.72384   35.01970  1.000 18.20824 ? 112 TYR A C   1 
ATOM   960  O  O   . TYR A 1 115 ? -40.40249 9.78663   35.02039  1.000 19.93180 ? 112 TYR A O   1 
ATOM   961  C  CB  . TYR A 1 115 ? -42.65263 7.43897   35.43951  1.000 16.66452 ? 112 TYR A CB  1 
ATOM   962  C  CG  . TYR A 1 115 ? -43.23606 7.37510   34.05546  1.000 23.15875 ? 112 TYR A CG  1 
ATOM   963  C  CD1 . TYR A 1 115 ? -44.60137 7.58049   33.84031  1.000 21.95812 ? 112 TYR A CD1 1 
ATOM   964  C  CD2 . TYR A 1 115 ? -42.43824 7.05006   32.96196  1.000 19.11411 ? 112 TYR A CD2 1 
ATOM   965  C  CE1 . TYR A 1 115 ? -45.13748 7.49404   32.58400  1.000 20.36084 ? 112 TYR A CE1 1 
ATOM   966  C  CE2 . TYR A 1 115 ? -42.98059 6.95554   31.67375  1.000 16.62011 ? 112 TYR A CE2 1 
ATOM   967  C  CZ  . TYR A 1 115 ? -44.31730 7.17506   31.49591  1.000 21.24008 ? 112 TYR A CZ  1 
ATOM   968  O  OH  . TYR A 1 115 ? -44.84479 7.09321   30.23775  1.000 18.77136 ? 112 TYR A OH  1 
ATOM   969  N  N   . LEU A 1 116 ? -42.39743 10.43978  34.17393  1.000 18.33663 ? 113 LEU A N   1 
ATOM   970  C  CA  . LEU A 1 116 ? -41.78473 11.35400  33.21299  1.000 17.60632 ? 113 LEU A CA  1 
ATOM   971  C  C   . LEU A 1 116 ? -41.11939 12.53397  33.91519  1.000 22.12040 ? 113 LEU A C   1 
ATOM   972  O  O   . LEU A 1 116 ? -40.03654 12.98705  33.50660  1.000 22.05687 ? 113 LEU A O   1 
ATOM   973  C  CB  . LEU A 1 116 ? -42.83867 11.83921  32.21859  1.000 15.24542 ? 113 LEU A CB  1 
ATOM   974  C  CG  . LEU A 1 116 ? -43.37952 10.76654  31.27067  1.000 20.38428 ? 113 LEU A CG  1 
ATOM   975  C  CD1 . LEU A 1 116 ? -44.60492 11.28857  30.48948  1.000 17.01486 ? 113 LEU A CD1 1 
ATOM   976  C  CD2 . LEU A 1 116 ? -42.27585 10.28654  30.29599  1.000 19.91621 ? 113 LEU A CD2 1 
ATOM   977  N  N   . ALA A 1 117 ? -41.76290 13.05845  34.95585  1.000 17.56113 ? 114 ALA A N   1 
ATOM   978  C  CA  . ALA A 1 117 ? -41.19583 14.19290  35.67620  1.000 18.07278 ? 114 ALA A CA  1 
ATOM   979  C  C   . ALA A 1 117 ? -39.87686 13.81990  36.32451  1.000 20.40577 ? 114 ALA A C   1 
ATOM   980  O  O   . ALA A 1 117 ? -38.89578 14.56167  36.20942  1.000 16.60563 ? 114 ALA A O   1 
ATOM   981  C  CB  . ALA A 1 117 ? -42.19099 14.71656  36.71171  1.000 18.68935 ? 114 ALA A CB  1 
ATOM   982  N  N   . THR A 1 118 ? -39.80012 12.64743  36.95713  1.000 16.44544 ? 115 THR A N   1 
ATOM   983  C  CA  . THR A 1 118 ? -38.52675 12.33667  37.58610  1.000 19.71064 ? 115 THR A CA  1 
ATOM   984  C  C   . THR A 1 118 ? -37.47401 11.93447  36.55649  1.000 17.79705 ? 115 THR A C   1 
ATOM   985  O  O   . THR A 1 118 ? -36.29482 12.22462  36.75932  1.000 19.36913 ? 115 THR A O   1 
ATOM   986  C  CB  . THR A 1 118 ? -38.68479 11.27390  38.68776  1.000 21.07524 ? 115 THR A CB  1 
ATOM   987  O  OG1 . THR A 1 118 ? -37.40622 11.07861  39.30336  1.000 21.49799 ? 115 THR A OG1 1 
ATOM   988  C  CG2 . THR A 1 118 ? -39.16218 9.95180   38.14081  1.000 17.51419 ? 115 THR A CG2 1 
ATOM   989  N  N   . ALA A 1 119 ? -37.87041 11.32185  35.43294  1.000 18.44578 ? 116 ALA A N   1 
ATOM   990  C  CA  . ALA A 1 119 ? -36.92722 11.12348  34.32684  1.000 21.51739 ? 116 ALA A CA  1 
ATOM   991  C  C   . ALA A 1 119 ? -36.37898 12.46201  33.81389  1.000 20.00971 ? 116 ALA A C   1 
ATOM   992  O  O   . ALA A 1 119 ? -35.15934 12.65540  33.68897  1.000 15.85668 ? 116 ALA A O   1 
ATOM   993  C  CB  . ALA A 1 119 ? -37.61881 10.35112  33.19680  1.000 19.47581 ? 116 ALA A CB  1 
ATOM   994  N  N   . LEU A 1 120 ? -37.27330 13.40889  33.53959  1.000 18.26177 ? 117 LEU A N   1 
ATOM   995  C  CA  . LEU A 1 120 ? -36.85874 14.72596  33.05780  1.000 14.86229 ? 117 LEU A CA  1 
ATOM   996  C  C   . LEU A 1 120 ? -35.91813 15.41132  34.04210  1.000 18.13825 ? 117 LEU A C   1 
ATOM   997  O  O   . LEU A 1 120 ? -34.90595 16.00195  33.64708  1.000 19.61080 ? 117 LEU A O   1 
ATOM   998  C  CB  . LEU A 1 120 ? -38.09841 15.58635  32.81793  1.000 15.91003 ? 117 LEU A CB  1 
ATOM   999  C  CG  . LEU A 1 120 ? -37.84909 17.04759  32.42650  1.000 20.06973 ? 117 LEU A CG  1 
ATOM   1000 C  CD1 . LEU A 1 120 ? -36.96112 17.10413  31.19520  1.000 18.95296 ? 117 LEU A CD1 1 
ATOM   1001 C  CD2 . LEU A 1 120 ? -39.20718 17.69471  32.15433  1.000 20.21277 ? 117 LEU A CD2 1 
ATOM   1002 N  N   . LEU A 1 121 ? -36.28115 15.41382  35.32144  1.000 15.23848 ? 118 LEU A N   1 
ATOM   1003 C  CA  . LEU A 1 121 ? -35.43381 16.04350  36.33288  1.000 17.92194 ? 118 LEU A CA  1 
ATOM   1004 C  C   . LEU A 1 121 ? -34.05643 15.39972  36.39166  1.000 18.53193 ? 118 LEU A C   1 
ATOM   1005 O  O   . LEU A 1 121 ? -33.04854 16.09291  36.54433  1.000 16.67876 ? 118 LEU A O   1 
ATOM   1006 C  CB  . LEU A 1 121 ? -36.10196 15.93937  37.69092  1.000 17.76278 ? 118 LEU A CB  1 
ATOM   1007 C  CG  . LEU A 1 121 ? -37.33361 16.80750  37.78740  1.000 18.54793 ? 118 LEU A CG  1 
ATOM   1008 C  CD1 . LEU A 1 121 ? -38.19929 16.31460  38.95556  1.000 17.57067 ? 118 LEU A CD1 1 
ATOM   1009 C  CD2 . LEU A 1 121 ? -36.85063 18.22811  38.00421  1.000 17.11809 ? 118 LEU A CD2 1 
ATOM   1010 N  N   . THR A 1 122 ? -34.01416 14.06582  36.31454  1.000 17.55609 ? 119 THR A N   1 
ATOM   1011 C  CA  . THR A 1 122 ? -32.75742 13.32489  36.31027  1.000 19.74863 ? 119 THR A CA  1 
ATOM   1012 C  C   . THR A 1 122 ? -31.86084 13.75229  35.15396  1.000 19.46414 ? 119 THR A C   1 
ATOM   1013 O  O   . THR A 1 122 ? -30.66336 14.02226  35.33682  1.000 21.20227 ? 119 THR A O   1 
ATOM   1014 C  CB  . THR A 1 122 ? -33.06082 11.82616  36.21991  1.000 15.83106 ? 119 THR A CB  1 
ATOM   1015 O  OG1 . THR A 1 122 ? -33.79098 11.42837  37.38936  1.000 18.57138 ? 119 THR A OG1 1 
ATOM   1016 C  CG2 . THR A 1 122 ? -31.74096 11.02055  36.13944  1.000 16.08762 ? 119 THR A CG2 1 
ATOM   1017 N  N   . LEU A 1 123 ? -32.42650 13.80851  33.95423  1.000 18.61699 ? 120 LEU A N   1 
ATOM   1018 C  CA  . LEU A 1 123 ? -31.65742 14.16683  32.76886  1.000 18.12621 ? 120 LEU A CA  1 
ATOM   1019 C  C   . LEU A 1 123 ? -30.92303 15.48130  32.95305  1.000 21.68773 ? 120 LEU A C   1 
ATOM   1020 O  O   . LEU A 1 123 ? -29.79800 15.64886  32.46952  1.000 20.86383 ? 120 LEU A O   1 
ATOM   1021 C  CB  . LEU A 1 123 ? -32.59891 14.26128  31.56323  1.000 19.23106 ? 120 LEU A CB  1 
ATOM   1022 C  CG  . LEU A 1 123 ? -33.11979 12.93265  31.03731  1.000 18.43400 ? 120 LEU A CG  1 
ATOM   1023 C  CD1 . LEU A 1 123 ? -34.23870 13.18345  30.02308  1.000 19.11749 ? 120 LEU A CD1 1 
ATOM   1024 C  CD2 . LEU A 1 123 ? -31.97192 12.09566  30.41663  1.000 18.78497 ? 120 LEU A CD2 1 
ATOM   1025 N  N   . GLN A 1 124 ? -31.56017 16.44367  33.61717  1.000 18.60731 ? 121 GLN A N   1 
ATOM   1026 C  CA  . GLN A 1 124 ? -30.94983 17.75279  33.80211  1.000 20.67358 ? 121 GLN A CA  1 
ATOM   1027 C  C   . GLN A 1 124 ? -29.83868 17.75623  34.83816  1.000 23.07104 ? 121 GLN A C   1 
ATOM   1028 O  O   . GLN A 1 124 ? -29.27453 18.82259  35.07493  1.000 19.45513 ? 121 GLN A O   1 
ATOM   1029 C  CB  . GLN A 1 124 ? -32.02554 18.76855  34.19431  1.000 18.81043 ? 121 GLN A CB  1 
ATOM   1030 C  CG  . GLN A 1 124 ? -33.08147 18.96748  33.10584  1.000 24.48395 ? 121 GLN A CG  1 
ATOM   1031 C  CD  . GLN A 1 124 ? -34.27081 19.74626  33.61233  1.000 18.57198 ? 121 GLN A CD  1 
ATOM   1032 O  OE1 . GLN A 1 124 ? -34.21765 20.96453  33.70726  1.000 23.78664 ? 121 GLN A OE1 1 
ATOM   1033 N  NE2 . GLN A 1 124 ? -35.34340 19.04400  33.96176  1.000 16.15068 ? 121 GLN A NE2 1 
ATOM   1034 N  N   . GLN A 1 125 ? -29.51366 16.60956  35.43976  1.000 15.56224 ? 122 GLN A N   1 
ATOM   1035 C  CA  . GLN A 1 125 ? -28.44101 16.49002  36.40734  1.000 19.05882 ? 122 GLN A CA  1 
ATOM   1036 C  C   . GLN A 1 125 ? -27.34294 15.51753  36.00785  1.000 21.59459 ? 122 GLN A C   1 
ATOM   1037 O  O   . GLN A 1 125 ? -26.40336 15.32869  36.78159  1.000 22.08407 ? 122 GLN A O   1 
ATOM   1038 C  CB  . GLN A 1 125 ? -29.01657 16.06085  37.75385  1.000 17.60298 ? 122 GLN A CB  1 
ATOM   1039 C  CG  . GLN A 1 125 ? -30.07378 17.02258  38.23854  1.000 22.58706 ? 122 GLN A CG  1 
ATOM   1040 C  CD  . GLN A 1 125 ? -30.78007 16.48144  39.46116  1.000 20.55691 ? 122 GLN A CD  1 
ATOM   1041 O  OE1 . GLN A 1 125 ? -30.16502 16.28552  40.51509  1.000 20.63498 ? 122 GLN A OE1 1 
ATOM   1042 N  NE2 . GLN A 1 125 ? -32.06883 16.19898  39.31730  1.000 18.62298 ? 122 GLN A NE2 1 
ATOM   1043 N  N   . ILE A 1 126 ? -27.44028 14.88358  34.85095  1.000 18.70635 ? 123 ILE A N   1 
ATOM   1044 C  CA  . ILE A 1 126 ? -26.40173 13.98572  34.36952  1.000 22.91889 ? 123 ILE A CA  1 
ATOM   1045 C  C   . ILE A 1 126 ? -25.94263 14.44378  32.99380  1.000 18.13699 ? 123 ILE A C   1 
ATOM   1046 O  O   . ILE A 1 126 ? -26.68878 15.08148  32.24130  1.000 21.90891 ? 123 ILE A O   1 
ATOM   1047 C  CB  . ILE A 1 126 ? -26.88649 12.52066  34.32779  1.000 21.77377 ? 123 ILE A CB  1 
ATOM   1048 C  CG1 . ILE A 1 126 ? -28.04845 12.35031  33.35231  1.000 20.04018 ? 123 ILE A CG1 1 
ATOM   1049 C  CG2 . ILE A 1 126 ? -27.32619 12.05235  35.71592  1.000 21.76954 ? 123 ILE A CG2 1 
ATOM   1050 C  CD1 . ILE A 1 126 ? -28.49247 10.89679  33.20418  1.000 19.51393 ? 123 ILE A CD1 1 
ATOM   1051 N  N   . GLU A 1 127 ? -24.68602 14.12647  32.67540  1.000 22.03935 ? 124 GLU A N   1 
ATOM   1052 C  CA  . GLU A 1 127 ? -24.09833 14.47336  31.38475  1.000 21.75544 ? 124 GLU A CA  1 
ATOM   1053 C  C   . GLU A 1 127 ? -24.55429 13.45725  30.34177  1.000 23.23347 ? 124 GLU A C   1 
ATOM   1054 O  O   . GLU A 1 127 ? -24.18573 12.27385  30.39851  1.000 21.67734 ? 124 GLU A O   1 
ATOM   1055 C  CB  . GLU A 1 127 ? -22.57843 14.51851  31.49260  1.000 23.79889 ? 124 GLU A CB  1 
ATOM   1056 C  CG  . GLU A 1 127 ? -21.87560 14.87540  30.19799  1.000 33.82329 ? 124 GLU A CG  1 
ATOM   1057 C  CD  . GLU A 1 127 ? -20.35878 14.65451  30.29595  1.000 45.97988 ? 124 GLU A CD  1 
ATOM   1058 O  OE1 . GLU A 1 127 ? -19.80027 14.86577  31.39892  1.000 40.10212 ? 124 GLU A OE1 1 
ATOM   1059 O  OE2 . GLU A 1 127 ? -19.73940 14.24720  29.28207  1.000 50.10110 ? 124 GLU A OE2 1 
ATOM   1060 N  N   . LEU A 1 128 ? -25.33694 13.91923  29.37158  1.000 19.79758 ? 125 LEU A N   1 
ATOM   1061 C  CA  . LEU A 1 128 ? -25.91190 13.02510  28.37299  1.000 19.89998 ? 125 LEU A CA  1 
ATOM   1062 C  C   . LEU A 1 128 ? -26.25450 13.83201  27.12866  1.000 25.72643 ? 125 LEU A C   1 
ATOM   1063 O  O   . LEU A 1 128 ? -26.93289 14.85277  27.23343  1.000 28.75976 ? 125 LEU A O   1 
ATOM   1064 C  CB  . LEU A 1 128 ? -27.17662 12.35383  28.90925  1.000 20.06468 ? 125 LEU A CB  1 
ATOM   1065 C  CG  . LEU A 1 128 ? -27.71827 11.22229  28.04391  1.000 25.75791 ? 125 LEU A CG  1 
ATOM   1066 C  CD1 . LEU A 1 128 ? -26.98664 9.90575   28.35436  1.000 22.63139 ? 125 LEU A CD1 1 
ATOM   1067 C  CD2 . LEU A 1 128 ? -29.21773 11.07933  28.22791  1.000 23.00405 ? 125 LEU A CD2 1 
ATOM   1068 N  N   . LYS A 1 129 ? -25.80827 13.36831  25.96635  1.000 21.73836 ? 126 LYS A N   1 
ATOM   1069 C  CA  . LYS A 1 129 ? -26.12739 13.99437  24.68838  1.000 23.63562 ? 126 LYS A CA  1 
ATOM   1070 C  C   . LYS A 1 129 ? -26.93774 13.01562  23.85911  1.000 19.91011 ? 126 LYS A C   1 
ATOM   1071 O  O   . LYS A 1 129 ? -26.53267 11.86128  23.67909  1.000 21.95085 ? 126 LYS A O   1 
ATOM   1072 C  CB  . LYS A 1 129 ? -24.86883 14.40397  23.92275  1.000 24.21340 ? 126 LYS A CB  1 
ATOM   1073 C  CG  . LYS A 1 129 ? -24.42207 15.83179  24.21619  1.000 50.98671 ? 126 LYS A CG  1 
ATOM   1074 C  CD  . LYS A 1 129 ? -22.92239 16.03468  23.98714  1.000 61.85916 ? 126 LYS A CD  1 
ATOM   1075 C  CE  . LYS A 1 129 ? -22.54475 17.51615  24.05278  1.000 66.96439 ? 126 LYS A CE  1 
ATOM   1076 N  NZ  . LYS A 1 129 ? -23.11746 18.20103  25.25575  1.000 56.40659 ? 126 LYS A NZ  1 
ATOM   1077 N  N   . PHE A 1 130 ? -28.05960 13.48368  23.33605  1.000 18.49592 ? 127 PHE A N   1 
ATOM   1078 C  CA  . PHE A 1 130 ? -28.89438 12.63232  22.51401  1.000 18.86639 ? 127 PHE A CA  1 
ATOM   1079 C  C   . PHE A 1 130 ? -28.39243 12.61228  21.07511  1.000 23.16391 ? 127 PHE A C   1 
ATOM   1080 O  O   . PHE A 1 130 ? -27.81296 13.58131  20.57391  1.000 19.97185 ? 127 PHE A O   1 
ATOM   1081 C  CB  . PHE A 1 130 ? -30.34479 13.10397  22.56327  1.000 15.59601 ? 127 PHE A CB  1 
ATOM   1082 C  CG  . PHE A 1 130 ? -30.99502 12.89506  23.88642  1.000 15.45440 ? 127 PHE A CG  1 
ATOM   1083 C  CD1 . PHE A 1 130 ? -31.24387 11.61068  24.34892  1.000 17.91239 ? 127 PHE A CD1 1 
ATOM   1084 C  CD2 . PHE A 1 130 ? -31.36457 13.96779  24.66985  1.000 20.08268 ? 127 PHE A CD2 1 
ATOM   1085 C  CE1 . PHE A 1 130 ? -31.85599 11.39225  25.57437  1.000 20.23833 ? 127 PHE A CE1 1 
ATOM   1086 C  CE2 . PHE A 1 130 ? -31.98189 13.76152  25.90533  1.000 19.00028 ? 127 PHE A CE2 1 
ATOM   1087 C  CZ  . PHE A 1 130 ? -32.20963 12.46213  26.36291  1.000 19.33962 ? 127 PHE A CZ  1 
ATOM   1088 N  N   . ASN A 1 131 ? -28.62366 11.49481  20.41657  1.000 16.36124 ? 128 ASN A N   1 
ATOM   1089 C  CA  . ASN A 1 131 ? -28.24990 11.34749  19.02047  1.000 16.79621 ? 128 ASN A CA  1 
ATOM   1090 C  C   . ASN A 1 131 ? -29.32508 11.82666  18.05784  1.000 19.78276 ? 128 ASN A C   1 
ATOM   1091 O  O   . ASN A 1 131 ? -28.99555 12.54428  17.10541  1.000 22.24388 ? 128 ASN A O   1 
ATOM   1092 C  CB  . ASN A 1 131 ? -27.88317 9.89784   18.74972  1.000 19.89746 ? 128 ASN A CB  1 
ATOM   1093 C  CG  . ASN A 1 131 ? -26.59859 9.52056   19.44074  1.000 25.74608 ? 128 ASN A CG  1 
ATOM   1094 O  OD1 . ASN A 1 131 ? -25.72453 10.37652  19.63597  1.000 26.45930 ? 128 ASN A OD1 1 
ATOM   1095 N  ND2 . ASN A 1 131 ? -26.48643 8.27079   19.85367  1.000 24.49437 ? 128 ASN A ND2 1 
ATOM   1096 N  N   . PRO A 1 132 ? -30.59728 11.47548  18.23858  1.000 18.28894 ? 129 PRO A N   1 
ATOM   1097 C  CA  . PRO A 1 132 ? -31.62493 11.95497  17.28883  1.000 18.45474 ? 129 PRO A CA  1 
ATOM   1098 C  C   . PRO A 1 132 ? -31.77344 13.46134  17.37477  1.000 16.37075 ? 129 PRO A C   1 
ATOM   1099 O  O   . PRO A 1 132 ? -31.91340 14.00658  18.47552  1.000 19.65484 ? 129 PRO A O   1 
ATOM   1100 C  CB  . PRO A 1 132 ? -32.90268 11.25218  17.76416  1.000 22.50810 ? 129 PRO A CB  1 
ATOM   1101 C  CG  . PRO A 1 132 ? -32.42640 10.09711  18.55872  1.000 18.97372 ? 129 PRO A CG  1 
ATOM   1102 C  CD  . PRO A 1 132 ? -31.19516 10.58431  19.24711  1.000 17.80873 ? 129 PRO A CD  1 
ATOM   1103 N  N   . PRO A 1 133 ? -31.74112 14.16744  16.24429  1.000 18.29743 ? 130 PRO A N   1 
ATOM   1104 C  CA  . PRO A 1 133 ? -31.99279 15.62112  16.28814  1.000 17.93163 ? 130 PRO A CA  1 
ATOM   1105 C  C   . PRO A 1 133 ? -33.30572 15.98229  16.98098  1.000 15.66855 ? 130 PRO A C   1 
ATOM   1106 O  O   . PRO A 1 133 ? -33.36287 16.97686  17.70682  1.000 19.35394 ? 130 PRO A O   1 
ATOM   1107 C  CB  . PRO A 1 133 ? -31.98120 16.00596  14.79867  1.000 21.32978 ? 130 PRO A CB  1 
ATOM   1108 C  CG  . PRO A 1 133 ? -31.00128 14.99643  14.18524  1.000 19.48671 ? 130 PRO A CG  1 
ATOM   1109 C  CD  . PRO A 1 133 ? -31.33293 13.70915  14.90127  1.000 22.79364 ? 130 PRO A CD  1 
ATOM   1110 N  N   . ALA A 1 134 ? -34.35510 15.17118  16.80320  1.000 19.16104 ? 131 ALA A N   1 
ATOM   1111 C  CA  . ALA A 1 134 ? -35.62047 15.42015  17.49377  1.000 19.14656 ? 131 ALA A CA  1 
ATOM   1112 C  C   . ALA A 1 134 ? -35.43766 15.48346  19.00432  1.000 22.36257 ? 131 ALA A C   1 
ATOM   1113 O  O   . ALA A 1 134 ? -36.06359 16.31458  19.67514  1.000 18.08609 ? 131 ALA A O   1 
ATOM   1114 C  CB  . ALA A 1 134 ? -36.64884 14.33841  17.14218  1.000 18.21273 ? 131 ALA A CB  1 
ATOM   1115 N  N   . LEU A 1 135 ? -34.60457 14.59645  19.56750  1.000 15.72335 ? 132 LEU A N   1 
ATOM   1116 C  CA  . LEU A 1 135 ? -34.40479 14.64002  21.00608  1.000 18.02705 ? 132 LEU A CA  1 
ATOM   1117 C  C   . LEU A 1 135 ? -33.48341 15.78093  21.39990  1.000 20.32819 ? 132 LEU A C   1 
ATOM   1118 O  O   . LEU A 1 135 ? -33.72730 16.43573  22.41508  1.000 19.09098 ? 132 LEU A O   1 
ATOM   1119 C  CB  . LEU A 1 135 ? -33.86856 13.30544  21.51037  1.000 21.14916 ? 132 LEU A CB  1 
ATOM   1120 C  CG  . LEU A 1 135 ? -34.86810 12.15326  21.57626  1.000 20.58261 ? 132 LEU A CG  1 
ATOM   1121 C  CD1 . LEU A 1 135 ? -34.14825 10.84540  21.94033  1.000 20.32004 ? 132 LEU A CD1 1 
ATOM   1122 C  CD2 . LEU A 1 135 ? -35.99451 12.43216  22.61316  1.000 18.77439 ? 132 LEU A CD2 1 
ATOM   1123 N  N   . GLN A 1 136 ? -32.42316 16.03279  20.62107  1.000 14.81757 ? 133 GLN A N   1 
ATOM   1124 C  CA  . GLN A 1 136 ? -31.56175 17.18676  20.90037  1.000 19.50219 ? 133 GLN A CA  1 
ATOM   1125 C  C   . GLN A 1 136 ? -32.37042 18.47855  20.91577  1.000 21.48669 ? 133 GLN A C   1 
ATOM   1126 O  O   . GLN A 1 136 ? -32.25392 19.29917  21.84184  1.000 20.60828 ? 133 GLN A O   1 
ATOM   1127 C  CB  . GLN A 1 136 ? -30.47135 17.30532  19.84308  1.000 16.81280 ? 133 GLN A CB  1 
ATOM   1128 C  CG  . GLN A 1 136 ? -29.56206 16.09180  19.71286  1.000 18.21108 ? 133 GLN A CG  1 
ATOM   1129 C  CD  . GLN A 1 136 ? -28.60798 16.24807  18.54200  1.000 25.20090 ? 133 GLN A CD  1 
ATOM   1130 O  OE1 . GLN A 1 136 ? -28.73401 17.18688  17.76524  1.000 32.06019 ? 133 GLN A OE1 1 
ATOM   1131 N  NE2 . GLN A 1 136 ? -27.65356 15.34598  18.41697  1.000 25.36368 ? 133 GLN A NE2 1 
ATOM   1132 N  N   . ASP A 1 137 ? -33.16502 18.68713  19.85632  1.000 18.41108 ? 134 ASP A N   1 
ATOM   1133 C  CA  . ASP A 1 137 ? -33.94394 19.91433  19.72782  1.000 18.11190 ? 134 ASP A CA  1 
ATOM   1134 C  C   . ASP A 1 137 ? -34.95569 20.01342  20.85404  1.000 20.72402 ? 134 ASP A C   1 
ATOM   1135 O  O   . ASP A 1 137 ? -35.07653 21.05297  21.51128  1.000 20.97506 ? 134 ASP A O   1 
ATOM   1136 C  CB  . ASP A 1 137 ? -34.66243 19.94893  18.38646  1.000 19.69957 ? 134 ASP A CB  1 
ATOM   1137 C  CG  . ASP A 1 137 ? -33.74072 20.13653  17.20950  1.000 21.19449 ? 134 ASP A CG  1 
ATOM   1138 O  OD1 . ASP A 1 137 ? -32.52762 20.40555  17.39529  1.000 22.77780 ? 134 ASP A OD1 1 
ATOM   1139 O  OD2 . ASP A 1 137 ? -34.26823 20.02207  16.07512  1.000 23.08808 ? 134 ASP A OD2 1 
ATOM   1140 N  N   . ALA A 1 138 ? -35.68971 18.92713  21.10205  1.000 18.24739 ? 135 ALA A N   1 
ATOM   1141 C  CA  . ALA A 1 138 ? -36.72853 18.99586  22.11894  1.000 17.32337 ? 135 ALA A CA  1 
ATOM   1142 C  C   . ALA A 1 138 ? -36.13085 19.09334  23.52279  1.000 20.98804 ? 135 ALA A C   1 
ATOM   1143 O  O   . ALA A 1 138 ? -36.65728 19.81428  24.36859  1.000 23.50243 ? 135 ALA A O   1 
ATOM   1144 C  CB  . ALA A 1 138 ? -37.67279 17.80360  21.99209  1.000 16.61585 ? 135 ALA A CB  1 
ATOM   1145 N  N   . TYR A 1 139 ? -35.01688 18.40878  23.78578  1.000 19.42063 ? 136 TYR A N   1 
ATOM   1146 C  CA  . TYR A 1 139 ? -34.41860 18.50652  25.11599  1.000 19.32395 ? 136 TYR A CA  1 
ATOM   1147 C  C   . TYR A 1 139 ? -33.92724 19.91949  25.39558  1.000 19.30494 ? 136 TYR A C   1 
ATOM   1148 O  O   . TYR A 1 139 ? -34.06420 20.42185  26.51049  1.000 20.21673 ? 136 TYR A O   1 
ATOM   1149 C  CB  . TYR A 1 139 ? -33.27044 17.51683  25.25640  1.000 20.03883 ? 136 TYR A CB  1 
ATOM   1150 C  CG  . TYR A 1 139 ? -32.67472 17.45735  26.63654  1.000 23.74302 ? 136 TYR A CG  1 
ATOM   1151 C  CD1 . TYR A 1 139 ? -33.48005 17.31761  27.76643  1.000 22.89852 ? 136 TYR A CD1 1 
ATOM   1152 C  CD2 . TYR A 1 139 ? -31.30000 17.50094  26.81230  1.000 30.08858 ? 136 TYR A CD2 1 
ATOM   1153 C  CE1 . TYR A 1 139 ? -32.92008 17.24324  29.03554  1.000 23.48149 ? 136 TYR A CE1 1 
ATOM   1154 C  CE2 . TYR A 1 139 ? -30.74006 17.43142  28.05848  1.000 33.15202 ? 136 TYR A CE2 1 
ATOM   1155 C  CZ  . TYR A 1 139 ? -31.54476 17.30490  29.17103  1.000 31.31808 ? 136 TYR A CZ  1 
ATOM   1156 O  OH  . TYR A 1 139 ? -30.94682 17.23230  30.41528  1.000 32.42013 ? 136 TYR A OH  1 
ATOM   1157 N  N   . TYR A 1 140 ? -33.34727 20.57568  24.38657  1.000 20.59217 ? 137 TYR A N   1 
ATOM   1158 C  CA  . TYR A 1 140 ? -32.93274 21.96295  24.55377  1.000 23.60827 ? 137 TYR A CA  1 
ATOM   1159 C  C   . TYR A 1 140 ? -34.11590 22.83233  24.96477  1.000 23.82498 ? 137 TYR A C   1 
ATOM   1160 O  O   . TYR A 1 140 ? -34.01348 23.63295  25.89738  1.000 22.57871 ? 137 TYR A O   1 
ATOM   1161 C  CB  . TYR A 1 140 ? -32.30047 22.44941  23.25154  1.000 24.41971 ? 137 TYR A CB  1 
ATOM   1162 C  CG  . TYR A 1 140 ? -31.81878 23.87977  23.27225  1.000 27.52411 ? 137 TYR A CG  1 
ATOM   1163 C  CD1 . TYR A 1 140 ? -30.53334 24.18831  23.68895  1.000 29.66162 ? 137 TYR A CD1 1 
ATOM   1164 C  CD2 . TYR A 1 140 ? -32.64552 24.91931  22.84916  1.000 30.80840 ? 137 TYR A CD2 1 
ATOM   1165 C  CE1 . TYR A 1 140 ? -30.07432 25.49811  23.68833  1.000 38.54438 ? 137 TYR A CE1 1 
ATOM   1166 C  CE2 . TYR A 1 140 ? -32.19612 26.24008  22.85863  1.000 33.41156 ? 137 TYR A CE2 1 
ATOM   1167 C  CZ  . TYR A 1 140 ? -30.91115 26.51562  23.27577  1.000 32.46294 ? 137 TYR A CZ  1 
ATOM   1168 O  OH  . TYR A 1 140 ? -30.45429 27.81586  23.28209  1.000 50.04501 ? 137 TYR A OH  1 
ATOM   1169 N  N   . ARG A 1 141 ? -35.25959 22.65329  24.30599  1.000 18.39972 ? 138 ARG A N   1 
ATOM   1170 C  CA  . ARG A 1 141 ? -36.45156 23.40822  24.66803  1.000 20.74289 ? 138 ARG A CA  1 
ATOM   1171 C  C   . ARG A 1 141 ? -36.93926 23.04670  26.06520  1.000 26.23253 ? 138 ARG A C   1 
ATOM   1172 O  O   . ARG A 1 141 ? -37.46602 23.90189  26.78378  1.000 25.40985 ? 138 ARG A O   1 
ATOM   1173 C  CB  . ARG A 1 141 ? -37.55394 23.15653  23.63956  1.000 23.62871 ? 138 ARG A CB  1 
ATOM   1174 C  CG  . ARG A 1 141 ? -37.36670 23.99135  22.39031  1.000 27.27627 ? 138 ARG A CG  1 
ATOM   1175 C  CD  . ARG A 1 141 ? -38.22295 23.56573  21.19442  1.000 31.95230 ? 138 ARG A CD  1 
ATOM   1176 N  NE  . ARG A 1 141 ? -39.67273 23.46480  21.36295  1.000 41.39828 ? 138 ARG A NE  1 
ATOM   1177 C  CZ  . ARG A 1 141 ? -40.49693 24.43666  21.74363  1.000 45.37015 ? 138 ARG A CZ  1 
ATOM   1178 N  NH1 . ARG A 1 141 ? -40.05355 25.56205  22.28784  1.000 47.77735 ? 138 ARG A NH1 1 
ATOM   1179 N  NH2 . ARG A 1 141 ? -41.80685 24.26909  21.58804  1.000 44.23615 ? 138 ARG A NH2 1 
ATOM   1180 N  N   . ALA A 1 142 ? -36.80274 21.77372  26.45064  1.000 24.19994 ? 139 ALA A N   1 
ATOM   1181 C  CA  . ALA A 1 142 ? -37.26778 21.34886  27.76035  1.000 19.68977 ? 139 ALA A CA  1 
ATOM   1182 C  C   . ALA A 1 142 ? -36.41781 21.97227  28.85786  1.000 21.71106 ? 139 ALA A C   1 
ATOM   1183 O  O   . ALA A 1 142 ? -36.93569 22.36616  29.89840  1.000 25.57483 ? 139 ALA A O   1 
ATOM   1184 C  CB  . ALA A 1 142 ? -37.24144 19.82366  27.84969  1.000 17.18051 ? 139 ALA A CB  1 
ATOM   1185 N  N   . ARG A 1 143 ? -35.10974 22.06684  28.63434  1.000 18.65577 ? 140 ARG A N   1 
ATOM   1186 C  CA  . ARG A 1 143 ? -34.24118 22.70607  29.61172  1.000 23.68435 ? 140 ARG A CA  1 
ATOM   1187 C  C   . ARG A 1 143 ? -34.63990 24.15990  29.80109  1.000 27.48793 ? 140 ARG A C   1 
ATOM   1188 O  O   . ARG A 1 143 ? -34.58967 24.68586  30.91756  1.000 28.91570 ? 140 ARG A O   1 
ATOM   1189 C  CB  . ARG A 1 143 ? -32.78250 22.59539  29.16614  1.000 22.67479 ? 140 ARG A CB  1 
ATOM   1190 C  CG  . ARG A 1 143 ? -32.19537 21.18250  29.24464  1.000 26.44883 ? 140 ARG A CG  1 
ATOM   1191 C  CD  . ARG A 1 143 ? -30.67645 21.19476  28.96446  1.000 36.74921 ? 140 ARG A CD  1 
ATOM   1192 N  NE  . ARG A 1 143 ? -29.91748 21.43956  30.18916  1.000 53.00763 ? 140 ARG A NE  1 
ATOM   1193 C  CZ  . ARG A 1 143 ? -29.23910 20.51764  30.87083  1.000 48.57770 ? 140 ARG A CZ  1 
ATOM   1194 N  NH1 . ARG A 1 143 ? -29.09633 19.27312  30.41893  1.000 34.18191 ? 140 ARG A NH1 1 
ATOM   1195 N  NH2 . ARG A 1 143 ? -28.68843 20.85105  32.03850  1.000 49.54644 ? 140 ARG A NH2 1 
ATOM   1196 N  N   . ALA A 1 144 ? -35.05357 24.81974  28.71351  1.000 26.10132 ? 141 ALA A N   1 
ATOM   1197 C  CA  . ALA A 1 144 ? -35.51415 26.20397  28.75882  1.000 27.72947 ? 141 ALA A CA  1 
ATOM   1198 C  C   . ALA A 1 144 ? -36.87838 26.35678  29.40631  1.000 24.84789 ? 141 ALA A C   1 
ATOM   1199 O  O   . ALA A 1 144 ? -37.25442 27.48158  29.72950  1.000 31.10081 ? 141 ALA A O   1 
ATOM   1200 C  CB  . ALA A 1 144 ? -35.57344 26.79230  27.34490  1.000 20.46882 ? 141 ALA A CB  1 
ATOM   1201 N  N   . GLY A 1 145 ? -37.62982 25.27422  29.58810  1.000 28.04787 ? 142 GLY A N   1 
ATOM   1202 C  CA  . GLY A 1 145 ? -38.93897 25.31599  30.22678  1.000 21.85637 ? 142 GLY A CA  1 
ATOM   1203 C  C   . GLY A 1 145 ? -40.08835 24.83789  29.35560  1.000 27.67570 ? 142 GLY A C   1 
ATOM   1204 O  O   . GLY A 1 145 ? -41.20894 24.66728  29.85725  1.000 27.43669 ? 142 GLY A O   1 
ATOM   1205 N  N   . GLU A 1 146 ? -39.88370 24.62239  28.06506  1.000 18.88117 ? 143 GLU A N   1 
ATOM   1206 C  CA  . GLU A 1 146 ? -40.97000 24.24968  27.16473  1.000 24.52687 ? 143 GLU A CA  1 
ATOM   1207 C  C   . GLU A 1 146 ? -40.74691 22.79077  26.78261  1.000 21.52746 ? 143 GLU A C   1 
ATOM   1208 O  O   . GLU A 1 146 ? -40.18733 22.47244  25.73106  1.000 24.83167 ? 143 GLU A O   1 
ATOM   1209 C  CB  . GLU A 1 146 ? -41.02364 25.13733  25.97084  1.000 24.79837 ? 143 GLU A CB  1 
ATOM   1210 C  CG  . GLU A 1 146 ? -41.44662 26.55473  26.30917  1.000 40.06913 ? 143 GLU A CG  1 
ATOM   1211 C  CD  . GLU A 1 146 ? -40.84561 27.56027  25.35764  1.000 57.95144 ? 143 GLU A CD  1 
ATOM   1212 O  OE1 . GLU A 1 146 ? -40.43191 27.15953  24.23730  1.000 57.28639 ? 143 GLU A OE1 1 
ATOM   1213 O  OE2 . GLU A 1 146 ? -40.77500 28.74814  25.73869  1.000 71.39424 ? 143 GLU A OE2 1 
ATOM   1214 N  N   . ALA A 1 147 ? -41.20788 21.90473  27.66266  1.000 22.22833 ? 144 ALA A N   1 
ATOM   1215 C  CA  . ALA A 1 147 ? -40.88453 20.49271  27.61116  1.000 18.32377 ? 144 ALA A CA  1 
ATOM   1216 C  C   . ALA A 1 147 ? -41.98058 19.64958  26.98520  1.000 20.57960 ? 144 ALA A C   1 
ATOM   1217 O  O   . ALA A 1 147 ? -41.89662 18.42556  27.04569  1.000 20.30849 ? 144 ALA A O   1 
ATOM   1218 C  CB  . ALA A 1 147 ? -40.57350 19.98227  29.02501  1.000 19.53782 ? 144 ALA A CB  1 
ATOM   1219 N  N   . ALA A 1 148 ? -42.99742 20.26675  26.37753  1.000 17.63099 ? 145 ALA A N   1 
ATOM   1220 C  CA  . ALA A 1 148 ? -44.11147 19.50042  25.81357  1.000 18.74791 ? 145 ALA A CA  1 
ATOM   1221 C  C   . ALA A 1 148 ? -43.65384 18.53385  24.71355  1.000 17.05882 ? 145 ALA A C   1 
ATOM   1222 O  O   . ALA A 1 148 ? -44.03157 17.35886  24.70618  1.000 18.75382 ? 145 ALA A O   1 
ATOM   1223 C  CB  . ALA A 1 148 ? -45.17726 20.45767  25.27285  1.000 19.18494 ? 145 ALA A CB  1 
ATOM   1224 N  N   . ASN A 1 149 ? -42.87039 19.01533  23.74502  1.000 18.01834 ? 146 ASN A N   1 
ATOM   1225 C  CA  . ASN A 1 149 ? -42.44370 18.11605  22.67459  1.000 20.29187 ? 146 ASN A CA  1 
ATOM   1226 C  C   . ASN A 1 149 ? -41.52446 17.02582  23.20738  1.000 16.94059 ? 146 ASN A C   1 
ATOM   1227 O  O   . ASN A 1 149 ? -41.64707 15.85710  22.81126  1.000 16.03391 ? 146 ASN A O   1 
ATOM   1228 C  CB  . ASN A 1 149 ? -41.75722 18.90116  21.55141  1.000 22.85701 ? 146 ASN A CB  1 
ATOM   1229 C  CG  . ASN A 1 149 ? -42.75812 19.58202  20.65112  1.000 22.81058 ? 146 ASN A CG  1 
ATOM   1230 O  OD1 . ASN A 1 149 ? -43.19584 19.02082  19.65115  1.000 37.69928 ? 146 ASN A OD1 1 
ATOM   1231 N  ND2 . ASN A 1 149 ? -43.15695 20.76441  21.02110  1.000 21.12681 ? 146 ASN A ND2 1 
ATOM   1232 N  N   . PHE A 1 150 ? -40.59799 17.38963  24.10475  1.000 19.13226 ? 147 PHE A N   1 
ATOM   1233 C  CA  . PHE A 1 150 ? -39.70277 16.39392  24.68390  1.000 18.87468 ? 147 PHE A CA  1 
ATOM   1234 C  C   . PHE A 1 150 ? -40.48739 15.27967  25.36697  1.000 18.50650 ? 147 PHE A C   1 
ATOM   1235 O  O   . PHE A 1 150 ? -40.22109 14.09112  25.14041  1.000 19.23440 ? 147 PHE A O   1 
ATOM   1236 C  CB  . PHE A 1 150 ? -38.73778 17.05303  25.66762  1.000 18.17557 ? 147 PHE A CB  1 
ATOM   1237 C  CG  . PHE A 1 150 ? -37.65416 16.13025  26.13964  1.000 23.77045 ? 147 PHE A CG  1 
ATOM   1238 C  CD1 . PHE A 1 150 ? -36.71782 15.63391  25.24451  1.000 21.82823 ? 147 PHE A CD1 1 
ATOM   1239 C  CD2 . PHE A 1 150 ? -37.57554 15.74082  27.46764  1.000 20.29178 ? 147 PHE A CD2 1 
ATOM   1240 C  CE1 . PHE A 1 150 ? -35.71655 14.77828  25.66531  1.000 22.30631 ? 147 PHE A CE1 1 
ATOM   1241 C  CE2 . PHE A 1 150 ? -36.56693 14.86900  27.89379  1.000 25.37415 ? 147 PHE A CE2 1 
ATOM   1242 C  CZ  . PHE A 1 150 ? -35.64155 14.39249  26.98658  1.000 22.80635 ? 147 PHE A CZ  1 
ATOM   1243 N  N   . CYS A 1 151 ? -41.49521 15.64375  26.17398  1.000 15.00283 ? 148 CYS A N   1 
ATOM   1244 C  CA  . CYS A 1 151 ? -42.25661 14.63103  26.89695  1.000 18.63699 ? 148 CYS A CA  1 
ATOM   1245 C  C   . CYS A 1 151 ? -43.06675 13.76576  25.94925  1.000 22.96622 ? 148 CYS A C   1 
ATOM   1246 O  O   . CYS A 1 151 ? -43.20888 12.55848  26.17943  1.000 17.13247 ? 148 CYS A O   1 
ATOM   1247 C  CB  . CYS A 1 151 ? -43.17526 15.27240  27.94250  1.000 17.20381 ? 148 CYS A CB  1 
ATOM   1248 S  SG  . CYS A 1 151 ? -42.26836 16.03942  29.31966  1.000 21.86434 ? 148 CYS A SG  1 
ATOM   1249 N  N   . ALA A 1 152 ? -43.61887 14.36122  24.88906  1.000 18.35839 ? 149 ALA A N   1 
ATOM   1250 C  CA  . ALA A 1 152 ? -44.34205 13.55748  23.90705  1.000 17.72979 ? 149 ALA A CA  1 
ATOM   1251 C  C   . ALA A 1 152 ? -43.38508 12.63754  23.16609  1.000 20.09564 ? 149 ALA A C   1 
ATOM   1252 O  O   . ALA A 1 152 ? -43.72180 11.48936  22.86460  1.000 18.80941 ? 149 ALA A O   1 
ATOM   1253 C  CB  . ALA A 1 152 ? -45.08795 14.46671  22.92516  1.000 15.39908 ? 149 ALA A CB  1 
ATOM   1254 N  N   . LEU A 1 153 ? -42.16970 13.11042  22.89973  1.000 16.56978 ? 150 LEU A N   1 
ATOM   1255 C  CA  . LEU A 1 153 ? -41.17822 12.22275  22.29972  1.000 19.46378 ? 150 LEU A CA  1 
ATOM   1256 C  C   . LEU A 1 153 ? -40.83591 11.05744  23.23256  1.000 19.18019 ? 150 LEU A C   1 
ATOM   1257 O  O   . LEU A 1 153 ? -40.73761 9.91380   22.77387  1.000 20.64379 ? 150 LEU A O   1 
ATOM   1258 C  CB  . LEU A 1 153 ? -39.92507 13.01043  21.90105  1.000 17.54865 ? 150 LEU A CB  1 
ATOM   1259 C  CG  . LEU A 1 153 ? -40.05674 13.83629  20.61436  1.000 18.98638 ? 150 LEU A CG  1 
ATOM   1260 C  CD1 . LEU A 1 153 ? -38.78711 14.66386  20.33849  1.000 18.40361 ? 150 LEU A CD1 1 
ATOM   1261 C  CD2 . LEU A 1 153 ? -40.39583 12.94506  19.39407  1.000 14.24487 ? 150 LEU A CD2 1 
ATOM   1262 N  N   . ILE A 1 154 ? -40.64869 11.30994  24.53758  1.000 18.63751 ? 151 ILE A N   1 
ATOM   1263 C  CA  . ILE A 1 154 ? -40.33693 10.19207  25.44226  1.000 17.39810 ? 151 ILE A CA  1 
ATOM   1264 C  C   . ILE A 1 154 ? -41.43533 9.13481   25.36200  1.000 21.80686 ? 151 ILE A C   1 
ATOM   1265 O  O   . ILE A 1 154 ? -41.16187 7.92876   25.25391  1.000 17.76741 ? 151 ILE A O   1 
ATOM   1266 C  CB  . ILE A 1 154 ? -40.15194 10.66495  26.89519  1.000 20.74115 ? 151 ILE A CB  1 
ATOM   1267 C  CG1 . ILE A 1 154 ? -38.99725 11.65366  27.03038  1.000 22.90939 ? 151 ILE A CG1 1 
ATOM   1268 C  CG2 . ILE A 1 154 ? -39.93630 9.44492   27.83529  1.000 17.58633 ? 151 ILE A CG2 1 
ATOM   1269 C  CD1 . ILE A 1 154 ? -38.94383 12.29305  28.40873  1.000 19.02650 ? 151 ILE A CD1 1 
ATOM   1270 N  N   . LEU A 1 155 ? -42.69684 9.57827   25.37788  1.000 18.30424 ? 152 LEU A N   1 
ATOM   1271 C  CA  . LEU A 1 155 ? -43.81924 8.64237   25.30440  1.000 21.62658 ? 152 LEU A CA  1 
ATOM   1272 C  C   . LEU A 1 155 ? -43.78015 7.84246   24.00561  1.000 22.19633 ? 152 LEU A C   1 
ATOM   1273 O  O   . LEU A 1 155 ? -43.90750 6.61021   24.01672  1.000 21.36659 ? 152 LEU A O   1 
ATOM   1274 C  CB  . LEU A 1 155 ? -45.13834 9.41152   25.43126  1.000 16.18901 ? 152 LEU A CB  1 
ATOM   1275 C  CG  . LEU A 1 155 ? -45.40769 9.93867   26.83322  1.000 21.78496 ? 152 LEU A CG  1 
ATOM   1276 C  CD1 . LEU A 1 155 ? -46.43659 11.05002  26.78042  1.000 23.01103 ? 152 LEU A CD1 1 
ATOM   1277 C  CD2 . LEU A 1 155 ? -45.88416 8.78774   27.69504  1.000 16.35527 ? 152 LEU A CD2 1 
ATOM   1278 N  N   . ALA A 1 156 ? -43.57328 8.53258   22.87622  1.000 19.88549 ? 153 ALA A N   1 
ATOM   1279 C  CA  . ALA A 1 156 ? -43.47147 7.86745   21.57888  1.000 18.76934 ? 153 ALA A CA  1 
ATOM   1280 C  C   . ALA A 1 156 ? -42.31652 6.86709   21.54921  1.000 21.24262 ? 153 ALA A C   1 
ATOM   1281 O  O   . ALA A 1 156 ? -42.49664 5.71483   21.13714  1.000 24.55828 ? 153 ALA A O   1 
ATOM   1282 C  CB  . ALA A 1 156 ? -43.30926 8.90997   20.46598  1.000 25.02088 ? 153 ALA A CB  1 
ATOM   1283 N  N   . TYR A 1 157 ? -41.11802 7.29337   21.95878  1.000 19.02584 ? 154 TYR A N   1 
ATOM   1284 C  CA  . TYR A 1 157 ? -39.97532 6.37206   21.94735  1.000 20.42785 ? 154 TYR A CA  1 
ATOM   1285 C  C   . TYR A 1 157 ? -40.19960 5.16749   22.85985  1.000 23.92492 ? 154 TYR A C   1 
ATOM   1286 O  O   . TYR A 1 157 ? -39.78036 4.04811   22.53222  1.000 25.68941 ? 154 TYR A O   1 
ATOM   1287 C  CB  . TYR A 1 157 ? -38.69249 7.09761   22.33897  1.000 16.61857 ? 154 TYR A CB  1 
ATOM   1288 C  CG  . TYR A 1 157 ? -38.10476 7.92296   21.21929  1.000 15.92778 ? 154 TYR A CG  1 
ATOM   1289 C  CD1 . TYR A 1 157 ? -37.53380 7.30722   20.10397  1.000 19.69398 ? 154 TYR A CD1 1 
ATOM   1290 C  CD2 . TYR A 1 157 ? -38.11370 9.31667   21.27351  1.000 17.84629 ? 154 TYR A CD2 1 
ATOM   1291 C  CE1 . TYR A 1 157 ? -36.98737 8.05760   19.06223  1.000 18.71956 ? 154 TYR A CE1 1 
ATOM   1292 C  CE2 . TYR A 1 157 ? -37.55219 10.08448  20.23639  1.000 19.30026 ? 154 TYR A CE2 1 
ATOM   1293 C  CZ  . TYR A 1 157 ? -37.00169 9.44625   19.13709  1.000 18.57955 ? 154 TYR A CZ  1 
ATOM   1294 O  OH  . TYR A 1 157 ? -36.46702 10.20506  18.12749  1.000 17.19814 ? 154 TYR A OH  1 
ATOM   1295 N  N   . CYS A 1 158 ? -40.87569 5.35526   23.98805  1.000 21.21890 ? 155 CYS A N   1 
ATOM   1296 C  CA  . CYS A 1 158 ? -41.10288 4.23821   24.90838  1.000 22.48309 ? 155 CYS A CA  1 
ATOM   1297 C  C   . CYS A 1 158 ? -42.34031 3.42593   24.58709  1.000 25.01367 ? 155 CYS A C   1 
ATOM   1298 O  O   . CYS A 1 158 ? -42.61882 2.45401   25.29412  1.000 27.23915 ? 155 CYS A O   1 
ATOM   1299 C  CB  . CYS A 1 158 ? -41.20821 4.73863   26.33763  1.000 22.50316 ? 155 CYS A CB  1 
ATOM   1300 S  SG  . CYS A 1 158 ? -39.71871 5.51076   26.86753  1.000 24.69682 ? 155 CYS A SG  1 
ATOM   1301 N  N   . ASN A 1 159 ? -43.09896 3.80658   23.56148  1.000 23.03780 ? 156 ASN A N   1 
ATOM   1302 C  CA  . ASN A 1 159 ? -44.36887 3.16192   23.23958  1.000 24.70502 ? 156 ASN A CA  1 
ATOM   1303 C  C   . ASN A 1 159 ? -45.31416 3.17360   24.42439  1.000 28.91230 ? 156 ASN A C   1 
ATOM   1304 O  O   . ASN A 1 159 ? -45.97970 2.17883   24.72118  1.000 27.76996 ? 156 ASN A O   1 
ATOM   1305 C  CB  . ASN A 1 159 ? -44.16680 1.73266   22.75062  1.000 31.33013 ? 156 ASN A CB  1 
ATOM   1306 C  CG  . ASN A 1 159 ? -44.02335 1.66978   21.27518  1.000 41.75280 ? 156 ASN A CG  1 
ATOM   1307 O  OD1 . ASN A 1 159 ? -42.90537 1.75939   20.75218  1.000 34.34873 ? 156 ASN A OD1 1 
ATOM   1308 N  ND2 . ASN A 1 159 ? -45.16043 1.53971   20.57117  1.000 39.45936 ? 156 ASN A ND2 1 
ATOM   1309 N  N   . LYS A 1 160 ? -45.34967 4.29497   25.12390  1.000 23.83717 ? 157 LYS A N   1 
ATOM   1310 C  CA  . LYS A 1 160 ? -46.30192 4.50723   26.18942  1.000 22.39570 ? 157 LYS A CA  1 
ATOM   1311 C  C   . LYS A 1 160 ? -47.24646 5.58826   25.71761  1.000 23.86444 ? 157 LYS A C   1 
ATOM   1312 O  O   . LYS A 1 160 ? -46.81426 6.54951   25.08137  1.000 26.40250 ? 157 LYS A O   1 
ATOM   1313 C  CB  . LYS A 1 160 ? -45.61467 4.94169   27.48386  1.000 22.61206 ? 157 LYS A CB  1 
ATOM   1314 C  CG  . LYS A 1 160 ? -44.71421 3.87398   28.08233  1.000 24.14350 ? 157 LYS A CG  1 
ATOM   1315 C  CD  . LYS A 1 160 ? -45.58406 2.73940   28.63741  1.000 30.56741 ? 157 LYS A CD  1 
ATOM   1316 C  CE  . LYS A 1 160 ? -44.82252 1.43107   28.61223  1.000 36.50341 ? 157 LYS A CE  1 
ATOM   1317 N  NZ  . LYS A 1 160 ? -45.66752 0.31263   29.10524  1.000 36.68377 ? 157 LYS A NZ  1 
ATOM   1318 N  N   . THR A 1 161 ? -48.52332 5.43141   26.02289  1.000 20.51466 ? 158 THR A N   1 
ATOM   1319 C  CA  . THR A 1 161 ? -49.47799 6.49980   25.77727  1.000 19.95451 ? 158 THR A CA  1 
ATOM   1320 C  C   . THR A 1 161 ? -49.68224 7.31052   27.05015  1.000 23.45327 ? 158 THR A C   1 
ATOM   1321 O  O   . THR A 1 161 ? -49.39916 6.85859   28.16585  1.000 25.13512 ? 158 THR A O   1 
ATOM   1322 C  CB  . THR A 1 161 ? -50.81725 5.93958   25.28647  1.000 23.44514 ? 158 THR A CB  1 
ATOM   1323 O  OG1 . THR A 1 161 ? -51.35684 5.08654   26.28822  1.000 24.85840 ? 158 THR A OG1 1 
ATOM   1324 C  CG2 . THR A 1 161 ? -50.62571 5.13184   24.02755  1.000 31.44569 ? 158 THR A CG2 1 
ATOM   1325 N  N   . VAL A 1 162 ? -50.14017 8.54585   26.85912  1.000 23.38789 ? 159 VAL A N   1 
ATOM   1326 C  CA  . VAL A 1 162 ? -50.52043 9.39645   27.97394  1.000 22.92220 ? 159 VAL A CA  1 
ATOM   1327 C  C   . VAL A 1 162 ? -51.45087 8.63759   28.90525  1.000 28.31341 ? 159 VAL A C   1 
ATOM   1328 O  O   . VAL A 1 162 ? -52.45627 8.06829   28.46960  1.000 27.41196 ? 159 VAL A O   1 
ATOM   1329 C  CB  . VAL A 1 162 ? -51.20120 10.66470  27.43840  1.000 28.16987 ? 159 VAL A CB  1 
ATOM   1330 C  CG1 . VAL A 1 162 ? -51.77377 11.46388  28.56235  1.000 25.12791 ? 159 VAL A CG1 1 
ATOM   1331 C  CG2 . VAL A 1 162 ? -50.21753 11.47436  26.64712  1.000 21.49131 ? 159 VAL A CG2 1 
ATOM   1332 N  N   . GLY A 1 163 ? -51.13370 8.64341   30.19625  1.000 27.42465 ? 160 GLY A N   1 
ATOM   1333 C  CA  . GLY A 1 163 ? -51.95699 7.99135   31.18284  1.000 22.21515 ? 160 GLY A CA  1 
ATOM   1334 C  C   . GLY A 1 163 ? -51.54529 6.57592   31.50947  1.000 23.98632 ? 160 GLY A C   1 
ATOM   1335 O  O   . GLY A 1 163 ? -51.95414 6.05483   32.54487  1.000 28.32838 ? 160 GLY A O   1 
ATOM   1336 N  N   . GLU A 1 164 ? -50.74248 5.94574   30.65933  1.000 25.32801 ? 161 GLU A N   1 
ATOM   1337 C  CA  . GLU A 1 164 ? -50.22643 4.61212   30.93756  1.000 26.64458 ? 161 GLU A CA  1 
ATOM   1338 C  C   . GLU A 1 164 ? -49.17150 4.65213   32.03636  1.000 30.65787 ? 161 GLU A C   1 
ATOM   1339 O  O   . GLU A 1 164 ? -48.36933 5.58455   32.11131  1.000 26.27760 ? 161 GLU A O   1 
ATOM   1340 C  CB  . GLU A 1 164 ? -49.60170 4.02938   29.68478  1.000 25.89115 ? 161 GLU A CB  1 
ATOM   1341 C  CG  . GLU A 1 164 ? -50.42271 3.03157   28.97293  1.000 32.84786 ? 161 GLU A CG  1 
ATOM   1342 C  CD  . GLU A 1 164 ? -49.58839 2.29467   27.96097  1.000 35.00013 ? 161 GLU A CD  1 
ATOM   1343 O  OE1 . GLU A 1 164 ? -49.17567 2.93088   26.97114  1.000 28.20401 ? 161 GLU A OE1 1 
ATOM   1344 O  OE2 . GLU A 1 164 ? -49.31743 1.09533   28.17552  1.000 46.52664 ? 161 GLU A OE2 1 
ATOM   1345 N  N   . LEU A 1 165 ? -49.13845 3.60234   32.86365  1.000 27.15963 ? 162 LEU A N   1 
ATOM   1346 C  CA  . LEU A 1 165 ? -48.17279 3.56440   33.94930  1.000 28.51698 ? 162 LEU A CA  1 
ATOM   1347 C  C   . LEU A 1 165 ? -46.79955 3.21669   33.38266  1.000 26.22508 ? 162 LEU A C   1 
ATOM   1348 O  O   . LEU A 1 165 ? -46.66870 2.32756   32.53401  1.000 30.77391 ? 162 LEU A O   1 
ATOM   1349 C  CB  . LEU A 1 165 ? -48.61900 2.58592   35.04470  1.000 44.82522 ? 162 LEU A CB  1 
ATOM   1350 C  CG  . LEU A 1 165 ? -48.49429 1.05539   35.10754  1.000 44.70116 ? 162 LEU A CG  1 
ATOM   1351 C  CD1 . LEU A 1 165 ? -49.22811 0.53047   36.35484  1.000 52.66284 ? 162 LEU A CD1 1 
ATOM   1352 C  CD2 . LEU A 1 165 ? -49.00174 0.32271   33.87311  1.000 56.21749 ? 162 LEU A CD2 1 
ATOM   1353 N  N   . GLY A 1 166 ? -45.78823 3.98054   33.78781  1.000 22.67863 ? 163 GLY A N   1 
ATOM   1354 C  CA  . GLY A 1 166 ? -44.45566 3.80511   33.23384  1.000 20.80684 ? 163 GLY A CA  1 
ATOM   1355 C  C   . GLY A 1 166 ? -43.44592 3.44925   34.30631  1.000 25.34165 ? 163 GLY A C   1 
ATOM   1356 O  O   . GLY A 1 166 ? -43.67984 3.70347   35.48805  1.000 20.13205 ? 163 GLY A O   1 
ATOM   1357 N  N   . ASP A 1 167 ? -42.31983 2.86402   33.91418  1.000 21.62099 ? 164 ASP A N   1 
ATOM   1358 C  CA  . ASP A 1 167 ? -41.24930 2.50219   34.82723  1.000 20.02736 ? 164 ASP A CA  1 
ATOM   1359 C  C   . ASP A 1 167 ? -40.05105 3.39872   34.52561  1.000 21.42883 ? 164 ASP A C   1 
ATOM   1360 O  O   . ASP A 1 167 ? -39.71567 3.61318   33.35793  1.000 20.24306 ? 164 ASP A O   1 
ATOM   1361 C  CB  . ASP A 1 167 ? -40.91988 1.00747   34.67575  1.000 23.20430 ? 164 ASP A CB  1 
ATOM   1362 C  CG  . ASP A 1 167 ? -39.69135 0.58406   35.44625  1.000 27.59499 ? 164 ASP A CG  1 
ATOM   1363 O  OD1 . ASP A 1 167 ? -39.77764 0.38615   36.68629  1.000 25.02538 ? 164 ASP A OD1 1 
ATOM   1364 O  OD2 . ASP A 1 167 ? -38.62871 0.42654   34.79289  1.000 21.84890 ? 164 ASP A OD2 1 
ATOM   1365 N  N   . VAL A 1 168 ? -39.43342 3.95722   35.57463  1.000 18.96656 ? 165 VAL A N   1 
ATOM   1366 C  CA  . VAL A 1 168 ? -38.36109 4.92254   35.35239  1.000 19.03856 ? 165 VAL A CA  1 
ATOM   1367 C  C   . VAL A 1 168 ? -37.14013 4.23576   34.75559  1.000 16.50551 ? 165 VAL A C   1 
ATOM   1368 O  O   . VAL A 1 168 ? -36.54074 4.73649   33.80539  1.000 21.05466 ? 165 VAL A O   1 
ATOM   1369 C  CB  . VAL A 1 168 ? -38.03257 5.67147   36.65882  1.000 20.54718 ? 165 VAL A CB  1 
ATOM   1370 C  CG1 . VAL A 1 168 ? -36.68136 6.40831   36.55380  1.000 18.54489 ? 165 VAL A CG1 1 
ATOM   1371 C  CG2 . VAL A 1 168 ? -39.15244 6.67039   36.96986  1.000 19.45623 ? 165 VAL A CG2 1 
ATOM   1372 N  N   . ARG A 1 169 ? -36.77701 3.06165   35.27128  1.000 16.21992 ? 166 ARG A N   1 
ATOM   1373 C  CA  . ARG A 1 169 ? -35.60629 2.36800   34.75461  1.000 21.03875 ? 166 ARG A CA  1 
ATOM   1374 C  C   . ARG A 1 169 ? -35.78066 2.07699   33.27114  1.000 14.13228 ? 166 ARG A C   1 
ATOM   1375 O  O   . ARG A 1 169 ? -34.86516 2.29929   32.46654  1.000 19.13865 ? 166 ARG A O   1 
ATOM   1376 C  CB  . ARG A 1 169 ? -35.35783 1.06714   35.53915  1.000 17.68146 ? 166 ARG A CB  1 
ATOM   1377 C  CG  . ARG A 1 169 ? -34.04775 0.37916   35.12945  1.000 19.15185 ? 166 ARG A CG  1 
ATOM   1378 C  CD  . ARG A 1 169 ? -34.17553 -1.14512  35.07881  1.000 22.63587 ? 166 ARG A CD  1 
ATOM   1379 N  NE  . ARG A 1 169 ? -34.76646 -1.59339  33.82918  1.000 22.75858 ? 166 ARG A NE  1 
ATOM   1380 C  CZ  . ARG A 1 169 ? -34.07411 -1.78147  32.71911  1.000 23.64292 ? 166 ARG A CZ  1 
ATOM   1381 N  NH1 . ARG A 1 169 ? -32.75354 -1.70649  32.71752  1.000 21.74801 ? 166 ARG A NH1 1 
ATOM   1382 N  NH2 . ARG A 1 169 ? -34.72609 -2.01609  31.57709  1.000 26.10499 ? 166 ARG A NH2 1 
ATOM   1383 N  N   . GLU A 1 170 ? -36.95859 1.57715   32.89301  1.000 17.21950 ? 167 GLU A N   1 
ATOM   1384 C  CA  . GLU A 1 170 ? -37.21810 1.24851   31.49227  1.000 19.26397 ? 167 GLU A CA  1 
ATOM   1385 C  C   . GLU A 1 170 ? -37.17444 2.49408   30.61895  1.000 16.60600 ? 167 GLU A C   1 
ATOM   1386 O  O   . GLU A 1 170 ? -36.61663 2.47373   29.51058  1.000 15.85639 ? 167 GLU A O   1 
ATOM   1387 C  CB  . GLU A 1 170 ? -38.58121 0.56799   31.36530  1.000 16.37583 ? 167 GLU A CB  1 
ATOM   1388 C  CG  . GLU A 1 170 ? -38.88773 -0.01749  29.98096  1.000 20.12080 ? 167 GLU A CG  1 
ATOM   1389 C  CD  . GLU A 1 170 ? -38.19307 -1.35221  29.74394  1.000 20.68600 ? 167 GLU A CD  1 
ATOM   1390 O  OE1 . GLU A 1 170 ? -37.39842 -1.80252  30.61396  1.000 19.54787 ? 167 GLU A OE1 1 
ATOM   1391 O  OE2 . GLU A 1 170 ? -38.45076 -1.96593  28.68436  1.000 23.41335 ? 167 GLU A OE2 1 
ATOM   1392 N  N   . THR A 1 171 ? -37.77269 3.58319   31.10574  1.000 19.26701 ? 168 THR A N   1 
ATOM   1393 C  CA  . THR A 1 171 ? -37.75258 4.85149   30.37917  1.000 17.30853 ? 168 THR A CA  1 
ATOM   1394 C  C   . THR A 1 171 ? -36.32254 5.34759   30.15939  1.000 17.72791 ? 168 THR A C   1 
ATOM   1395 O  O   . THR A 1 171 ? -35.96341 5.76569   29.05196  1.000 19.05261 ? 168 THR A O   1 
ATOM   1396 C  CB  . THR A 1 171 ? -38.57897 5.89748   31.13068  1.000 17.26897 ? 168 THR A CB  1 
ATOM   1397 O  OG1 . THR A 1 171 ? -39.91149 5.40033   31.31560  1.000 18.25800 ? 168 THR A OG1 1 
ATOM   1398 C  CG2 . THR A 1 171 ? -38.69271 7.17776   30.29881  1.000 18.79649 ? 168 THR A CG2 1 
ATOM   1399 N  N   . MET A 1 172 ? -35.50082 5.33113   31.20725  1.000 18.06852 ? 169 MET A N   1 
ATOM   1400 C  CA  . MET A 1 172 ? -34.11178 5.74703   31.05245  1.000 19.16765 ? 169 MET A CA  1 
ATOM   1401 C  C   . MET A 1 172 ? -33.37914 4.83313   30.08053  1.000 17.33327 ? 169 MET A C   1 
ATOM   1402 O  O   . MET A 1 172 ? -32.51993 5.28898   29.31740  1.000 20.60513 ? 169 MET A O   1 
ATOM   1403 C  CB  . MET A 1 172 ? -33.39596 5.76193   32.40664  1.000 18.39928 ? 169 MET A CB  1 
ATOM   1404 C  CG  . MET A 1 172 ? -34.01101 6.69711   33.47029  1.000 19.27594 ? 169 MET A CG  1 
ATOM   1405 S  SD  . MET A 1 172 ? -34.19245 8.44201   32.94861  1.000 22.63942 ? 169 MET A SD  1 
ATOM   1406 C  CE  . MET A 1 172 ? -32.51080 8.98847   32.74153  1.000 19.75919 ? 169 MET A CE  1 
ATOM   1407 N  N   . SER A 1 173 ? -33.70398 3.53705   30.09038  1.000 17.18648 ? 170 SER A N   1 
ATOM   1408 C  CA  . SER A 1 173 ? -33.07424 2.63584   29.13093  1.000 17.56706 ? 170 SER A CA  1 
ATOM   1409 C  C   . SER A 1 173 ? -33.33337 3.09051   27.69637  1.000 20.28541 ? 170 SER A C   1 
ATOM   1410 O  O   . SER A 1 173 ? -32.40908 3.14895   26.88217  1.000 19.90987 ? 170 SER A O   1 
ATOM   1411 C  CB  . SER A 1 173 ? -33.57229 1.21608   29.34650  1.000 24.57196 ? 170 SER A CB  1 
ATOM   1412 O  OG  . SER A 1 173 ? -32.88028 0.36270   28.47339  1.000 31.03518 ? 170 SER A OG  1 
ATOM   1413 N  N   . TYR A 1 174 ? -34.57299 3.47857   27.38578  1.000 18.09733 ? 171 TYR A N   1 
ATOM   1414 C  CA  . TYR A 1 174 ? -34.89830 3.95248   26.04325  1.000 21.12245 ? 171 TYR A CA  1 
ATOM   1415 C  C   . TYR A 1 174 ? -34.15575 5.23387   25.71155  1.000 21.81003 ? 171 TYR A C   1 
ATOM   1416 O  O   . TYR A 1 174 ? -33.59294 5.37669   24.61983  1.000 25.27801 ? 171 TYR A O   1 
ATOM   1417 C  CB  . TYR A 1 174 ? -36.39701 4.18470   25.91912  1.000 20.17110 ? 171 TYR A CB  1 
ATOM   1418 C  CG  . TYR A 1 174 ? -37.17267 2.95401   25.58302  1.000 25.17387 ? 171 TYR A CG  1 
ATOM   1419 C  CD1 . TYR A 1 174 ? -37.19777 2.44975   24.28697  1.000 19.15974 ? 171 TYR A CD1 1 
ATOM   1420 C  CD2 . TYR A 1 174 ? -37.89321 2.30167   26.54616  1.000 23.61026 ? 171 TYR A CD2 1 
ATOM   1421 C  CE1 . TYR A 1 174 ? -37.93634 1.31248   23.97972  1.000 27.21712 ? 171 TYR A CE1 1 
ATOM   1422 C  CE2 . TYR A 1 174 ? -38.63304 1.17215   26.25118  1.000 29.12797 ? 171 TYR A CE2 1 
ATOM   1423 C  CZ  . TYR A 1 174 ? -38.64388 0.68154   24.97653  1.000 27.88381 ? 171 TYR A CZ  1 
ATOM   1424 O  OH  . TYR A 1 174 ? -39.38029 -0.44109  24.70961  1.000 28.54033 ? 171 TYR A OH  1 
ATOM   1425 N  N   . LEU A 1 175 ? -34.15578 6.18653   26.63635  1.000 21.53973 ? 172 LEU A N   1 
ATOM   1426 C  CA  . LEU A 1 175 ? -33.44090 7.43267   26.39432  1.000 18.23054 ? 172 LEU A CA  1 
ATOM   1427 C  C   . LEU A 1 175 ? -31.94552 7.18967   26.20360  1.000 22.62945 ? 172 LEU A C   1 
ATOM   1428 O  O   . LEU A 1 175 ? -31.33521 7.77185   25.29772  1.000 19.84384 ? 172 LEU A O   1 
ATOM   1429 C  CB  . LEU A 1 175 ? -33.69417 8.39881   27.54346  1.000 17.30644 ? 172 LEU A CB  1 
ATOM   1430 C  CG  . LEU A 1 175 ? -35.16233 8.83346   27.65233  1.000 23.93330 ? 172 LEU A CG  1 
ATOM   1431 C  CD1 . LEU A 1 175 ? -35.42339 9.53547   28.94318  1.000 17.69903 ? 172 LEU A CD1 1 
ATOM   1432 C  CD2 . LEU A 1 175 ? -35.53509 9.75324   26.50659  1.000 23.36709 ? 172 LEU A CD2 1 
ATOM   1433 N  N   . PHE A 1 176 ? -31.33979 6.31951   27.03247  1.000 18.70329 ? 173 PHE A N   1 
ATOM   1434 C  CA  . PHE A 1 176 ? -29.91303 6.01088   26.88036  1.000 16.95845 ? 173 PHE A CA  1 
ATOM   1435 C  C   . PHE A 1 176 ? -29.63001 5.32169   25.55393  1.000 19.60905 ? 173 PHE A C   1 
ATOM   1436 O  O   . PHE A 1 176 ? -28.55679 5.50735   24.95872  1.000 21.69585 ? 173 PHE A O   1 
ATOM   1437 C  CB  . PHE A 1 176 ? -29.43632 5.12105   28.03340  1.000 20.10855 ? 173 PHE A CB  1 
ATOM   1438 C  CG  . PHE A 1 176 ? -29.45185 5.80497   29.37197  1.000 20.61396 ? 173 PHE A CG  1 
ATOM   1439 C  CD1 . PHE A 1 176 ? -29.54033 7.18419   29.46366  1.000 22.20175 ? 173 PHE A CD1 1 
ATOM   1440 C  CD2 . PHE A 1 176 ? -29.38400 5.06780   30.54424  1.000 22.27772 ? 173 PHE A CD2 1 
ATOM   1441 C  CE1 . PHE A 1 176 ? -29.54843 7.82846   30.71399  1.000 19.59428 ? 173 PHE A CE1 1 
ATOM   1442 C  CE2 . PHE A 1 176 ? -29.38104 5.69612   31.77706  1.000 22.75541 ? 173 PHE A CE2 1 
ATOM   1443 C  CZ  . PHE A 1 176 ? -29.47014 7.07792   31.86435  1.000 21.94747 ? 173 PHE A CZ  1 
ATOM   1444 N  N   . GLN A 1 177 ? -30.56710 4.49481   25.10227  1.000 15.55287 ? 174 GLN A N   1 
ATOM   1445 C  CA  . GLN A 1 177 ? -30.45588 3.85572   23.80611  1.000 22.55356 ? 174 GLN A CA  1 
ATOM   1446 C  C   . GLN A 1 177 ? -30.23963 4.88328   22.71740  1.000 24.84645 ? 174 GLN A C   1 
ATOM   1447 O  O   . GLN A 1 177 ? -29.54504 4.61203   21.73559  1.000 23.27423 ? 174 GLN A O   1 
ATOM   1448 C  CB  . GLN A 1 177 ? -31.72827 3.05542   23.54196  1.000 22.40461 ? 174 GLN A CB  1 
ATOM   1449 C  CG  . GLN A 1 177 ? -31.53489 1.64526   23.09334  1.000 41.02712 ? 174 GLN A CG  1 
ATOM   1450 C  CD  . GLN A 1 177 ? -30.60409 0.87536   23.99984  1.000 48.75908 ? 174 GLN A CD  1 
ATOM   1451 O  OE1 . GLN A 1 177 ? -29.50932 0.48584   23.57598  1.000 45.34176 ? 174 GLN A OE1 1 
ATOM   1452 N  NE2 . GLN A 1 177 ? -31.02489 0.64780   25.26006  1.000 37.53233 ? 174 GLN A NE2 1 
ATOM   1453 N  N   . HIS A 1 178 ? -30.81726 6.07772   22.87694  1.000 21.16324 ? 175 HIS A N   1 
ATOM   1454 C  CA  . HIS A 1 178 ? -30.70633 7.13254   21.87667  1.000 19.97952 ? 175 HIS A CA  1 
ATOM   1455 C  C   . HIS A 1 178 ? -29.71082 8.21402   22.27419  1.000 21.82948 ? 175 HIS A C   1 
ATOM   1456 O  O   . HIS A 1 178 ? -29.80295 9.34980   21.79637  1.000 19.04035 ? 175 HIS A O   1 
ATOM   1457 C  CB  . HIS A 1 178 ? -32.08184 7.74014   21.62160  1.000 23.03547 ? 175 HIS A CB  1 
ATOM   1458 C  CG  . HIS A 1 178 ? -32.96737 6.86641   20.78917  1.000 24.71945 ? 175 HIS A CG  1 
ATOM   1459 N  ND1 . HIS A 1 178 ? -32.70603 6.59947   19.46057  1.000 26.51681 ? 175 HIS A ND1 1 
ATOM   1460 C  CD2 . HIS A 1 178 ? -34.10073 6.19032   21.09599  1.000 26.32411 ? 175 HIS A CD2 1 
ATOM   1461 C  CE1 . HIS A 1 178 ? -33.64704 5.80463   18.98256  1.000 26.61467 ? 175 HIS A CE1 1 
ATOM   1462 N  NE2 . HIS A 1 178 ? -34.50581 5.54530   19.95317  1.000 23.01635 ? 175 HIS A NE2 1 
ATOM   1463 N  N   . ALA A 1 179 ? -28.77418 7.89479   23.15185  1.000 22.19952 ? 176 ALA A N   1 
ATOM   1464 C  CA  . ALA A 1 179 ? -27.76287 8.85076   23.54926  1.000 17.46204 ? 176 ALA A CA  1 
ATOM   1465 C  C   . ALA A 1 179 ? -26.39294 8.32538   23.16809  1.000 20.35087 ? 176 ALA A C   1 
ATOM   1466 O  O   . ALA A 1 179 ? -26.21338 7.13361   22.90541  1.000 21.82088 ? 176 ALA A O   1 
ATOM   1467 C  CB  . ALA A 1 179 ? -27.81641 9.13995   25.04568  1.000 18.44335 ? 176 ALA A CB  1 
ATOM   1468 N  N   . ASN A 1 180 ? -25.42153 9.23321   23.15529  1.000 22.30190 ? 177 ASN A N   1 
ATOM   1469 C  CA  . ASN A 1 180 ? -24.03800 8.85332   22.87541  1.000 25.54476 ? 177 ASN A CA  1 
ATOM   1470 C  C   . ASN A 1 180 ? -23.39365 8.41590   24.17706  1.000 21.90177 ? 177 ASN A C   1 
ATOM   1471 O  O   . ASN A 1 180 ? -22.90699 9.23979   24.95303  1.000 22.49240 ? 177 ASN A O   1 
ATOM   1472 C  CB  . ASN A 1 180 ? -23.23999 9.98427   22.24741  1.000 25.19324 ? 177 ASN A CB  1 
ATOM   1473 C  CG  . ASN A 1 180 ? -21.85266 9.52557   21.81517  1.000 29.35003 ? 177 ASN A CG  1 
ATOM   1474 O  OD1 . ASN A 1 180 ? -21.42537 8.39533   22.12577  1.000 26.14103 ? 177 ASN A OD1 1 
ATOM   1475 N  ND2 . ASN A 1 180 ? -21.14658 10.38545  21.09261  1.000 34.32699 ? 177 ASN A ND2 1 
ATOM   1476 N  N   . LEU A 1 181 ? -23.37705 7.10717   24.39392  1.000 21.08858 ? 178 LEU A N   1 
ATOM   1477 C  CA  . LEU A 1 181 ? -22.69383 6.49203   25.51701  1.000 25.33959 ? 178 LEU A CA  1 
ATOM   1478 C  C   . LEU A 1 181 ? -21.55285 5.60557   25.03829  1.000 25.10924 ? 178 LEU A C   1 
ATOM   1479 O  O   . LEU A 1 181 ? -21.11576 4.71265   25.76710  1.000 22.61983 ? 178 LEU A O   1 
ATOM   1480 C  CB  . LEU A 1 181 ? -23.69320 5.70203   26.36157  1.000 26.40910 ? 178 LEU A CB  1 
ATOM   1481 C  CG  . LEU A 1 181 ? -24.77960 6.58604   27.00849  1.000 23.75150 ? 178 LEU A CG  1 
ATOM   1482 C  CD1 . LEU A 1 181 ? -25.84974 5.73032   27.66968  1.000 25.31094 ? 178 LEU A CD1 1 
ATOM   1483 C  CD2 . LEU A 1 181 ? -24.16555 7.56057   28.01405  1.000 21.61516 ? 178 LEU A CD2 1 
ATOM   1484 N  N   . ASP A 1 182 ? -21.03527 5.87590   23.83765  1.000 27.00508 ? 179 ASP A N   1 
ATOM   1485 C  CA  . ASP A 1 182 ? -20.10372 4.95159   23.19181  1.000 27.86935 ? 179 ASP A CA  1 
ATOM   1486 C  C   . ASP A 1 182 ? -18.82485 4.78122   24.00330  1.000 33.94117 ? 179 ASP A C   1 
ATOM   1487 O  O   . ASP A 1 182 ? -18.27372 3.67895   24.07976  1.000 42.88094 ? 179 ASP A O   1 
ATOM   1488 C  CB  . ASP A 1 182 ? -19.78152 5.43474   21.78048  1.000 32.00857 ? 179 ASP A CB  1 
ATOM   1489 C  CG  . ASP A 1 182 ? -20.93671 5.21036   20.80530  1.000 36.77489 ? 179 ASP A CG  1 
ATOM   1490 O  OD1 . ASP A 1 182 ? -21.99804 4.69779   21.22876  1.000 39.51098 ? 179 ASP A OD1 1 
ATOM   1491 O  OD2 . ASP A 1 182 ? -20.78360 5.55713   19.61821  1.000 40.63678 ? 179 ASP A OD2 1 
ATOM   1492 N  N   . SER A 1 183 ? -18.35755 5.84301   24.63928  1.000 34.29966 ? 180 SER A N   1 
ATOM   1493 C  CA  . SER A 1 183 ? -17.12373 5.78430   25.40592  1.000 38.01191 ? 180 SER A CA  1 
ATOM   1494 C  C   . SER A 1 183 ? -17.32772 5.32812   26.85602  1.000 35.28168 ? 180 SER A C   1 
ATOM   1495 O  O   . SER A 1 183 ? -16.40697 5.46265   27.66531  1.000 44.36924 ? 180 SER A O   1 
ATOM   1496 C  CB  . SER A 1 183 ? -16.43665 7.14808   25.36409  1.000 30.10586 ? 180 SER A CB  1 
ATOM   1497 O  OG  . SER A 1 183 ? -17.16528 8.09890   26.11265  1.000 38.78388 ? 180 SER A OG  1 
ATOM   1498 N  N   . CYS A 1 184 ? -18.49712 4.79133   27.20669  1.000 26.03583 ? 181 CYS A N   1 
ATOM   1499 C  CA  . CYS A 1 184 ? -18.71068 4.23132   28.53493  1.000 20.97575 ? 181 CYS A CA  1 
ATOM   1500 C  C   . CYS A 1 184 ? -18.29608 2.76545   28.56854  1.000 24.42228 ? 181 CYS A C   1 
ATOM   1501 O  O   . CYS A 1 184 ? -18.64743 1.97805   27.68744  1.000 22.99464 ? 181 CYS A O   1 
ATOM   1502 C  CB  . CYS A 1 184 ? -20.16567 4.36170   28.97299  1.000 20.42070 ? 181 CYS A CB  1 
ATOM   1503 S  SG  . CYS A 1 184 ? -20.68711 6.09241   29.15857  1.000 22.16244 ? 181 CYS A SG  1 
ATOM   1504 N  N   . LYS A 1 185 ? -17.56700 2.40429   29.61364  1.000 21.62931 ? 182 LYS A N   1 
ATOM   1505 C  CA  . LYS A 1 185 ? -16.99242 1.07546   29.73982  1.000 25.69095 ? 182 LYS A CA  1 
ATOM   1506 C  C   . LYS A 1 185 ? -17.09311 0.65699   31.19521  1.000 21.96391 ? 182 LYS A C   1 
ATOM   1507 O  O   . LYS A 1 185 ? -16.94816 1.48539   32.10016  1.000 26.58164 ? 182 LYS A O   1 
ATOM   1508 C  CB  . LYS A 1 185 ? -15.52371 1.06244   29.26854  1.000 27.45492 ? 182 LYS A CB  1 
ATOM   1509 C  CG  . LYS A 1 185 ? -14.79991 -0.27819  29.39737  1.000 30.46028 ? 182 LYS A CG  1 
ATOM   1510 C  CD  . LYS A 1 185 ? -13.35197 -0.12068  28.91123  1.000 35.91551 ? 182 LYS A CD  1 
ATOM   1511 C  CE  . LYS A 1 185 ? -12.53362 -1.38575  29.10438  1.000 48.44889 ? 182 LYS A CE  1 
ATOM   1512 N  NZ  . LYS A 1 185 ? -11.07549 -1.10832  28.91367  1.000 57.90897 ? 182 LYS A NZ  1 
ATOM   1513 N  N   . ARG A 1 186 ? -17.36879 -0.62227  31.40456  1.000 22.44109 ? 183 ARG A N   1 
ATOM   1514 C  CA  . ARG A 1 186 ? -17.48813 -1.21006  32.72576  1.000 24.03863 ? 183 ARG A CA  1 
ATOM   1515 C  C   . ARG A 1 186 ? -16.85531 -2.58917  32.67584  1.000 26.58988 ? 183 ARG A C   1 
ATOM   1516 O  O   . ARG A 1 186 ? -17.15766 -3.36470  31.76376  1.000 23.52304 ? 183 ARG A O   1 
ATOM   1517 C  CB  . ARG A 1 186 ? -18.95229 -1.33001  33.15084  1.000 18.32585 ? 183 ARG A CB  1 
ATOM   1518 C  CG  . ARG A 1 186 ? -19.17871 -2.32068  34.27500  1.000 20.41709 ? 183 ARG A CG  1 
ATOM   1519 C  CD  . ARG A 1 186 ? -20.57838 -2.17467  34.83536  1.000 22.33926 ? 183 ARG A CD  1 
ATOM   1520 N  NE  . ARG A 1 186 ? -20.76466 -0.86909  35.44721  1.000 21.87059 ? 183 ARG A NE  1 
ATOM   1521 C  CZ  . ARG A 1 186 ? -21.92938 -0.39759  35.86499  1.000 20.17218 ? 183 ARG A CZ  1 
ATOM   1522 N  NH1 . ARG A 1 186 ? -23.04353 -1.09720  35.72821  1.000 18.35842 ? 183 ARG A NH1 1 
ATOM   1523 N  NH2 . ARG A 1 186 ? -21.97411 0.80498   36.43460  1.000 22.02303 ? 183 ARG A NH2 1 
ATOM   1524 N  N   . VAL A 1 187 ? -15.99556 -2.88804  33.65056  1.000 25.25277 ? 184 VAL A N   1 
ATOM   1525 C  CA  . VAL A 1 187 ? -15.42814 -4.21965  33.82562  1.000 23.27517 ? 184 VAL A CA  1 
ATOM   1526 C  C   . VAL A 1 187 ? -15.90195 -4.77457  35.15749  1.000 22.39608 ? 184 VAL A C   1 
ATOM   1527 O  O   . VAL A 1 187 ? -15.71844 -4.14203  36.20346  1.000 23.51433 ? 184 VAL A O   1 
ATOM   1528 C  CB  . VAL A 1 187 ? -13.89326 -4.22043  33.76870  1.000 29.00711 ? 184 VAL A CB  1 
ATOM   1529 C  CG1 . VAL A 1 187 ? -13.39727 -5.66154  33.77658  1.000 25.48150 ? 184 VAL A CG1 1 
ATOM   1530 C  CG2 . VAL A 1 187 ? -13.40535 -3.48583  32.51766  1.000 23.80086 ? 184 VAL A CG2 1 
ATOM   1531 N  N   . LEU A 1 188 ? -16.48210 -5.96951  35.10709  1.000 26.17647 ? 185 LEU A N   1 
ATOM   1532 C  CA  . LEU A 1 188 ? -17.00521 -6.69302  36.25236  1.000 25.75340 ? 185 LEU A CA  1 
ATOM   1533 C  C   . LEU A 1 188 ? -16.18042 -7.95387  36.44081  1.000 27.11295 ? 185 LEU A C   1 
ATOM   1534 O  O   . LEU A 1 188 ? -15.63556 -8.50068  35.48261  1.000 26.73849 ? 185 LEU A O   1 
ATOM   1535 C  CB  . LEU A 1 188 ? -18.47667 -7.07363  36.05167  1.000 27.61480 ? 185 LEU A CB  1 
ATOM   1536 C  CG  . LEU A 1 188 ? -19.44645 -5.90102  35.87749  1.000 25.76674 ? 185 LEU A CG  1 
ATOM   1537 C  CD1 . LEU A 1 188 ? -20.88490 -6.37635  35.75396  1.000 23.45926 ? 185 LEU A CD1 1 
ATOM   1538 C  CD2 . LEU A 1 188 ? -19.30373 -4.93625  37.03779  1.000 27.72137 ? 185 LEU A CD2 1 
ATOM   1539 N  N   . ASN A 1 189 ? -16.06629 -8.39884  37.68054  1.000 25.86293 ? 186 ASN A N   1 
ATOM   1540 C  CA  . ASN A 1 189 ? -15.53350 -9.72364  37.96252  1.000 27.25908 ? 186 ASN A CA  1 
ATOM   1541 C  C   . ASN A 1 189 ? -16.56385 -10.47841 38.78059  1.000 31.35578 ? 186 ASN A C   1 
ATOM   1542 O  O   . ASN A 1 189 ? -17.16200 -9.90961  39.70076  1.000 31.69120 ? 186 ASN A O   1 
ATOM   1543 C  CB  . ASN A 1 189 ? -14.19978 -9.65537  38.69835  1.000 28.54052 ? 186 ASN A CB  1 
ATOM   1544 C  CG  . ASN A 1 189 ? -13.46633 -10.97086 38.64771  1.000 34.50033 ? 186 ASN A CG  1 
ATOM   1545 O  OD1 . ASN A 1 189 ? -13.68718 -11.76877 37.73772  1.000 34.48789 ? 186 ASN A OD1 1 
ATOM   1546 N  ND2 . ASN A 1 189 ? -12.60524 -11.21363 39.61947  1.000 30.75042 ? 186 ASN A ND2 1 
ATOM   1547 N  N   . VAL A 1 190 ? -16.80940 -11.73532 38.41083  1.000 26.55714 ? 187 VAL A N   1 
ATOM   1548 C  CA  . VAL A 1 190 ? -17.66660 -12.62945 39.17792  1.000 26.78537 ? 187 VAL A CA  1 
ATOM   1549 C  C   . VAL A 1 190 ? -16.80384 -13.76754 39.70037  1.000 35.48749 ? 187 VAL A C   1 
ATOM   1550 O  O   . VAL A 1 190 ? -16.01689 -14.35256 38.94829  1.000 29.89348 ? 187 VAL A O   1 
ATOM   1551 C  CB  . VAL A 1 190 ? -18.83748 -13.16477 38.33846  1.000 29.58539 ? 187 VAL A CB  1 
ATOM   1552 C  CG1 . VAL A 1 190 ? -19.70969 -14.06662 39.18495  1.000 27.92789 ? 187 VAL A CG1 1 
ATOM   1553 C  CG2 . VAL A 1 190 ? -19.65954 -11.98760 37.75274  1.000 32.02217 ? 187 VAL A CG2 1 
ATOM   1554 N  N   . VAL A 1 191 ? -16.93633 -14.05715 40.98676  1.000 33.17720 ? 188 VAL A N   1 
ATOM   1555 C  CA  . VAL A 1 191 ? -16.05059 -14.96180 41.71125  1.000 37.79483 ? 188 VAL A CA  1 
ATOM   1556 C  C   . VAL A 1 191 ? -16.92640 -16.00417 42.38794  1.000 36.76676 ? 188 VAL A C   1 
ATOM   1557 O  O   . VAL A 1 191 ? -17.70152 -15.66991 43.29501  1.000 31.02045 ? 188 VAL A O   1 
ATOM   1558 C  CB  . VAL A 1 191 ? -15.20304 -14.22010 42.75387  1.000 37.68392 ? 188 VAL A CB  1 
ATOM   1559 C  CG1 . VAL A 1 191 ? -14.54989 -15.20806 43.71056  1.000 39.79714 ? 188 VAL A CG1 1 
ATOM   1560 C  CG2 . VAL A 1 191 ? -14.17202 -13.34145 42.07089  1.000 33.00547 ? 188 VAL A CG2 1 
ATOM   1561 N  N   . CYS A 1 192 ? -16.80641 -17.25761 41.95969  1.000 37.74106 ? 189 CYS A N   1 
ATOM   1562 C  CA  . CYS A 1 192 ? -17.45664 -18.37816 42.62999  1.000 37.58504 ? 189 CYS A CA  1 
ATOM   1563 C  C   . CYS A 1 192 ? -16.40739 -19.19382 43.37191  1.000 33.81475 ? 189 CYS A C   1 
ATOM   1564 O  O   . CYS A 1 192 ? -15.34962 -19.50565 42.81099  1.000 31.99865 ? 189 CYS A O   1 
ATOM   1565 C  CB  . CYS A 1 192 ? -18.19776 -19.27420 41.64183  1.000 35.19828 ? 189 CYS A CB  1 
ATOM   1566 S  SG  . CYS A 1 192 ? -19.08315 -20.61729 42.48454  1.000 30.39814 ? 189 CYS A SG  1 
ATOM   1567 N  N   . LYS A 1 193 ? -16.70281 -19.55038 44.62501  1.000 33.45163 ? 190 LYS A N   1 
ATOM   1568 C  CA  . LYS A 1 193 ? -15.74293 -20.35341 45.38500  1.000 42.48006 ? 190 LYS A CA  1 
ATOM   1569 C  C   . LYS A 1 193 ? -15.49841 -21.71255 44.73233  1.000 34.90892 ? 190 LYS A C   1 
ATOM   1570 O  O   . LYS A 1 193 ? -14.40734 -22.27690 44.86380  1.000 38.60845 ? 190 LYS A O   1 
ATOM   1571 C  CB  . LYS A 1 193 ? -16.21028 -20.53361 46.82665  1.000 40.09992 ? 190 LYS A CB  1 
ATOM   1572 C  CG  . LYS A 1 193 ? -15.07788 -20.98137 47.73681  1.000 52.78819 ? 190 LYS A CG  1 
ATOM   1573 C  CD  . LYS A 1 193 ? -15.54242 -21.32368 49.14178  1.000 51.80312 ? 190 LYS A CD  1 
ATOM   1574 C  CE  . LYS A 1 193 ? -14.38724 -21.90465 49.94757  1.000 56.97102 ? 190 LYS A CE  1 
ATOM   1575 N  NZ  . LYS A 1 193 ? -14.83105 -23.02908 50.81789  1.000 58.43065 ? 190 LYS A NZ  1 
ATOM   1576 N  N   . THR A 1 194 ? -16.48254 -22.24166 44.00683  1.000 38.57266 ? 191 THR A N   1 
ATOM   1577 C  CA  . THR A 1 194 ? -16.29822 -23.48329 43.26394  1.000 37.23946 ? 191 THR A CA  1 
ATOM   1578 C  C   . THR A 1 194 ? -15.70813 -23.24589 41.88105  1.000 41.48158 ? 191 THR A C   1 
ATOM   1579 O  O   . THR A 1 194 ? -14.70485 -23.86861 41.52339  1.000 39.66489 ? 191 THR A O   1 
ATOM   1580 C  CB  . THR A 1 194 ? -17.63145 -24.23376 43.10750  1.000 34.07761 ? 191 THR A CB  1 
ATOM   1581 O  OG1 . THR A 1 194 ? -18.11817 -24.63868 44.38923  1.000 34.08556 ? 191 THR A OG1 1 
ATOM   1582 C  CG2 . THR A 1 194 ? -17.45082 -25.47411 42.21539  1.000 28.54810 ? 191 THR A CG2 1 
ATOM   1583 N  N   . CYS A 1 195 ? -16.32493 -22.35423 41.09435  1.000 37.07987 ? 192 CYS A N   1 
ATOM   1584 C  CA  . CYS A 1 195 ? -16.03912 -22.23225 39.66816  1.000 31.45225 ? 192 CYS A CA  1 
ATOM   1585 C  C   . CYS A 1 195 ? -14.90898 -21.26376 39.34279  1.000 37.94151 ? 192 CYS A C   1 
ATOM   1586 O  O   . CYS A 1 195 ? -14.45077 -21.23342 38.19491  1.000 38.09975 ? 192 CYS A O   1 
ATOM   1587 C  CB  . CYS A 1 195 ? -17.31050 -21.80889 38.92673  1.000 35.93669 ? 192 CYS A CB  1 
ATOM   1588 S  SG  . CYS A 1 195 ? -18.70614 -22.89348 39.33440  1.000 37.25755 ? 192 CYS A SG  1 
ATOM   1589 N  N   . GLY A 1 196 ? -14.44634 -20.48131 40.30647  1.000 33.57396 ? 193 GLY A N   1 
ATOM   1590 C  CA  . GLY A 1 196 ? -13.38515 -19.53936 40.02827  1.000 38.94390 ? 193 GLY A CA  1 
ATOM   1591 C  C   . GLY A 1 196 ? -13.92088 -18.18325 39.60874  1.000 44.72248 ? 193 GLY A C   1 
ATOM   1592 O  O   . GLY A 1 196 ? -15.03518 -17.80133 39.98634  1.000 36.98553 ? 193 GLY A O   1 
ATOM   1593 N  N   . GLN A 1 197 ? -13.14126 -17.47046 38.80144  1.000 34.76300 ? 194 GLN A N   1 
ATOM   1594 C  CA  . GLN A 1 197 ? -13.39491 -16.08481 38.43827  1.000 38.43687 ? 194 GLN A CA  1 
ATOM   1595 C  C   . GLN A 1 197 ? -13.73944 -15.97812 36.96207  1.000 38.39195 ? 194 GLN A C   1 
ATOM   1596 O  O   . GLN A 1 197 ? -13.20854 -16.72225 36.13234  1.000 34.75106 ? 194 GLN A O   1 
ATOM   1597 C  CB  . GLN A 1 197 ? -12.17520 -15.21182 38.72612  1.000 35.35374 ? 194 GLN A CB  1 
ATOM   1598 C  CG  . GLN A 1 197 ? -11.64575 -15.37562 40.12956  1.000 47.33615 ? 194 GLN A CG  1 
ATOM   1599 C  CD  . GLN A 1 197 ? -10.76063 -14.22498 40.55076  1.000 54.89553 ? 194 GLN A CD  1 
ATOM   1600 O  OE1 . GLN A 1 197 ? -10.24652 -13.48650 39.70984  1.000 58.13214 ? 194 GLN A OE1 1 
ATOM   1601 N  NE2 . GLN A 1 197 ? -10.58809 -14.05559 41.86198  1.000 63.41557 ? 194 GLN A NE2 1 
ATOM   1602 N  N   . GLN A 1 198 ? -14.62290 -15.03933 36.63856  1.000 34.31783 ? 195 GLN A N   1 
ATOM   1603 C  CA  . GLN A 1 198 ? -14.94049 -14.71612 35.25516  1.000 29.99254 ? 195 GLN A CA  1 
ATOM   1604 C  C   . GLN A 1 198 ? -15.10850 -13.20963 35.17867  1.000 37.43337 ? 195 GLN A C   1 
ATOM   1605 O  O   . GLN A 1 198 ? -15.90320 -12.63618 35.93238  1.000 32.42378 ? 195 GLN A O   1 
ATOM   1606 C  CB  . GLN A 1 198 ? -16.20732 -15.42775 34.78777  1.000 32.05496 ? 195 GLN A CB  1 
ATOM   1607 C  CG  . GLN A 1 198 ? -16.60073 -15.10588 33.35915  1.000 36.64176 ? 195 GLN A CG  1 
ATOM   1608 C  CD  . GLN A 1 198 ? -15.59070 -15.61616 32.35880  1.000 46.31695 ? 195 GLN A CD  1 
ATOM   1609 O  OE1 . GLN A 1 198 ? -15.39993 -16.82626 32.22188  1.000 57.44404 ? 195 GLN A OE1 1 
ATOM   1610 N  NE2 . GLN A 1 198 ? -14.91933 -14.69611 31.66235  1.000 42.88266 ? 195 GLN A NE2 1 
ATOM   1611 N  N   . GLN A 1 199 ? -14.34195 -12.57572 34.30201  1.000 30.55965 ? 196 GLN A N   1 
ATOM   1612 C  CA  . GLN A 1 199 ? -14.42206 -11.14063 34.09571  1.000 35.10189 ? 196 GLN A CA  1 
ATOM   1613 C  C   . GLN A 1 199 ? -15.26159 -10.85399 32.85580  1.000 33.79134 ? 196 GLN A C   1 
ATOM   1614 O  O   . GLN A 1 199 ? -15.25269 -11.61870 31.88433  1.000 35.88588 ? 196 GLN A O   1 
ATOM   1615 C  CB  . GLN A 1 199 ? -13.01851 -10.54273 33.96695  1.000 34.35075 ? 196 GLN A CB  1 
ATOM   1616 C  CG  . GLN A 1 199 ? -12.97104 -9.13620  33.42910  1.000 38.97229 ? 196 GLN A CG  1 
ATOM   1617 C  CD  . GLN A 1 199 ? -11.55241 -8.62282  33.27149  1.000 38.92247 ? 196 GLN A CD  1 
ATOM   1618 O  OE1 . GLN A 1 199 ? -10.79133 -8.55857  34.23577  1.000 39.64638 ? 196 GLN A OE1 1 
ATOM   1619 N  NE2 . GLN A 1 199 ? -11.19142 -8.25274  32.04828  1.000 34.11841 ? 196 GLN A NE2 1 
ATOM   1620 N  N   . THR A 1 200 ? -16.01119 -9.75232  32.90807  1.000 31.16271 ? 197 THR A N   1 
ATOM   1621 C  CA  . THR A 1 200 ? -16.91489 -9.36375  31.83417  1.000 27.36607 ? 197 THR A CA  1 
ATOM   1622 C  C   . THR A 1 200 ? -16.77052 -7.86690  31.59748  1.000 32.95950 ? 197 THR A C   1 
ATOM   1623 O  O   . THR A 1 200 ? -16.74445 -7.09164  32.55492  1.000 29.80524 ? 197 THR A O   1 
ATOM   1624 C  CB  . THR A 1 200 ? -18.37156 -9.70689  32.18887  1.000 36.75439 ? 197 THR A CB  1 
ATOM   1625 O  OG1 . THR A 1 200 ? -18.50050 -11.12791 32.35050  1.000 39.98572 ? 197 THR A OG1 1 
ATOM   1626 C  CG2 . THR A 1 200 ? -19.32500 -9.25860  31.09053  1.000 33.41044 ? 197 THR A CG2 1 
ATOM   1627 N  N   . THR A 1 201 ? -16.67061 -7.46456  30.33397  1.000 33.54858 ? 198 THR A N   1 
ATOM   1628 C  CA  . THR A 1 201 ? -16.65581 -6.05671  29.95961  1.000 28.71189 ? 198 THR A CA  1 
ATOM   1629 C  C   . THR A 1 201 ? -17.99601 -5.69418  29.34369  1.000 29.45808 ? 198 THR A C   1 
ATOM   1630 O  O   . THR A 1 201 ? -18.53012 -6.43625  28.51121  1.000 27.05539 ? 198 THR A O   1 
ATOM   1631 C  CB  . THR A 1 201 ? -15.53248 -5.75408  28.96263  1.000 27.89736 ? 198 THR A CB  1 
ATOM   1632 O  OG1 . THR A 1 201 ? -14.28027 -6.04853  29.56866  1.000 29.50596 ? 198 THR A OG1 1 
ATOM   1633 C  CG2 . THR A 1 201 ? -15.53807 -4.29342  28.54367  1.000 26.11155 ? 198 THR A CG2 1 
ATOM   1634 N  N   . LEU A 1 202 ? -18.53225 -4.55244  29.76224  1.000 29.99243 ? 199 LEU A N   1 
ATOM   1635 C  CA  . LEU A 1 202 ? -19.76909 -4.01922  29.22513  1.000 27.19395 ? 199 LEU A CA  1 
ATOM   1636 C  C   . LEU A 1 202 ? -19.49625 -2.63925  28.63835  1.000 24.18967 ? 199 LEU A C   1 
ATOM   1637 O  O   . LEU A 1 202 ? -18.60637 -1.92073  29.09964  1.000 23.01204 ? 199 LEU A O   1 
ATOM   1638 C  CB  . LEU A 1 202 ? -20.83629 -3.94939  30.31521  1.000 20.69872 ? 199 LEU A CB  1 
ATOM   1639 C  CG  . LEU A 1 202 ? -21.17738 -5.27077  31.02583  1.000 29.02528 ? 199 LEU A CG  1 
ATOM   1640 C  CD1 . LEU A 1 202 ? -22.02484 -5.06391  32.25573  1.000 30.80314 ? 199 LEU A CD1 1 
ATOM   1641 C  CD2 . LEU A 1 202 ? -21.88821 -6.23933  30.07743  1.000 31.66894 ? 199 LEU A CD2 1 
ATOM   1642 N  N   . LYS A 1 203 ? -20.27134 -2.27127  27.61864  1.000 26.72377 ? 200 LYS A N   1 
ATOM   1643 C  CA  . LYS A 1 203 ? -20.09744 -1.00316  26.91929  1.000 28.75584 ? 200 LYS A CA  1 
ATOM   1644 C  C   . LYS A 1 203 ? -21.44353 -0.30689  26.74491  1.000 27.88034 ? 200 LYS A C   1 
ATOM   1645 O  O   . LYS A 1 203 ? -22.50129 -0.93744  26.77842  1.000 25.80264 ? 200 LYS A O   1 
ATOM   1646 C  CB  . LYS A 1 203 ? -19.44284 -1.21711  25.54267  1.000 29.83186 ? 200 LYS A CB  1 
ATOM   1647 C  CG  . LYS A 1 203 ? -18.11509 -1.95192  25.57768  1.000 31.19998 ? 200 LYS A CG  1 
ATOM   1648 C  CD  . LYS A 1 203 ? -16.92666 -1.02509  25.31724  1.000 42.73787 ? 200 LYS A CD  1 
ATOM   1649 C  CE  . LYS A 1 203 ? -15.68564 -1.84252  24.96118  1.000 47.46544 ? 200 LYS A CE  1 
ATOM   1650 N  NZ  . LYS A 1 203 ? -14.46183 -1.00269  24.73664  1.000 59.57444 ? 200 LYS A NZ  1 
ATOM   1651 N  N   . GLY A 1 204 ? -21.39334 1.00981   26.54589  1.000 27.55006 ? 201 GLY A N   1 
ATOM   1652 C  CA  . GLY A 1 204 ? -22.59794 1.74023   26.18638  1.000 24.11279 ? 201 GLY A CA  1 
ATOM   1653 C  C   . GLY A 1 204 ? -23.61196 1.71601   27.31289  1.000 24.74227 ? 201 GLY A C   1 
ATOM   1654 O  O   . GLY A 1 204 ? -23.26202 1.87048   28.48857  1.000 27.90417 ? 201 GLY A O   1 
ATOM   1655 N  N   . VAL A 1 205 ? -24.88276 1.49381   26.95725  1.000 22.06435 ? 202 VAL A N   1 
ATOM   1656 C  CA  . VAL A 1 205 ? -25.95707 1.55518   27.95314  1.000 20.66991 ? 202 VAL A CA  1 
ATOM   1657 C  C   . VAL A 1 205 ? -25.72704 0.52669   29.04779  1.000 22.85077 ? 202 VAL A C   1 
ATOM   1658 O  O   . VAL A 1 205 ? -25.93051 0.80908   30.23070  1.000 21.17202 ? 202 VAL A O   1 
ATOM   1659 C  CB  . VAL A 1 205 ? -27.34236 1.37150   27.29795  1.000 25.85587 ? 202 VAL A CB  1 
ATOM   1660 C  CG1 . VAL A 1 205 ? -28.44242 1.37284   28.35261  1.000 24.25860 ? 202 VAL A CG1 1 
ATOM   1661 C  CG2 . VAL A 1 205 ? -27.60868 2.47838   26.30312  1.000 28.73387 ? 202 VAL A CG2 1 
ATOM   1662 N  N   . GLU A 1 206 ? -25.30234 -0.67912  28.67831  1.000 20.20654 ? 203 GLU A N   1 
ATOM   1663 C  CA  . GLU A 1 206 ? -25.07442 -1.69461  29.69978  1.000 18.76918 ? 203 GLU A CA  1 
ATOM   1664 C  C   . GLU A 1 206 ? -23.91155 -1.34200  30.61378  1.000 22.16099 ? 203 GLU A C   1 
ATOM   1665 O  O   . GLU A 1 206 ? -23.77756 -1.95166  31.67665  1.000 23.06281 ? 203 GLU A O   1 
ATOM   1666 C  CB  . GLU A 1 206 ? -24.83088 -3.05177  29.06484  1.000 22.98228 ? 203 GLU A CB  1 
ATOM   1667 C  CG  . GLU A 1 206 ? -26.08042 -3.65398  28.40619  1.000 31.83581 ? 203 GLU A CG  1 
ATOM   1668 C  CD  . GLU A 1 206 ? -26.38583 -3.06266  27.02193  1.000 41.73403 ? 203 GLU A CD  1 
ATOM   1669 O  OE1 . GLU A 1 206 ? -25.55825 -2.27426  26.49122  1.000 37.14154 ? 203 GLU A OE1 1 
ATOM   1670 O  OE2 . GLU A 1 206 ? -27.45867 -3.39492  26.45519  1.000 47.85709 ? 203 GLU A OE2 1 
ATOM   1671 N  N   . ALA A 1 207 ? -23.06424 -0.38446  30.22401  1.000 18.94924 ? 204 ALA A N   1 
ATOM   1672 C  CA  . ALA A 1 207 ? -21.97888 0.03740   31.10133  1.000 24.16006 ? 204 ALA A CA  1 
ATOM   1673 C  C   . ALA A 1 207 ? -22.44658 0.96974   32.21234  1.000 22.50307 ? 204 ALA A C   1 
ATOM   1674 O  O   . ALA A 1 207 ? -21.72812 1.13048   33.20813  1.000 21.60777 ? 204 ALA A O   1 
ATOM   1675 C  CB  . ALA A 1 207 ? -20.85738 0.72157   30.30050  1.000 21.68004 ? 204 ALA A CB  1 
ATOM   1676 N  N   . VAL A 1 208 ? -23.61478 1.59967   32.08598  1.000 19.72856 ? 205 VAL A N   1 
ATOM   1677 C  CA  . VAL A 1 208 ? -23.99966 2.62035   33.05532  1.000 18.02583 ? 205 VAL A CA  1 
ATOM   1678 C  C   . VAL A 1 208 ? -25.21854 2.24434   33.87825  1.000 18.53639 ? 205 VAL A C   1 
ATOM   1679 O  O   . VAL A 1 208 ? -25.56436 2.97945   34.80658  1.000 18.71730 ? 205 VAL A O   1 
ATOM   1680 C  CB  . VAL A 1 208 ? -24.21148 3.99125   32.38322  1.000 20.82150 ? 205 VAL A CB  1 
ATOM   1681 C  CG1 . VAL A 1 208 ? -22.89903 4.40601   31.64180  1.000 21.66189 ? 205 VAL A CG1 1 
ATOM   1682 C  CG2 . VAL A 1 208 ? -25.41457 3.95272   31.45778  1.000 20.02840 ? 205 VAL A CG2 1 
ATOM   1683 N  N   . MET A 1 209 ? -25.85862 1.11501   33.59114  1.000 20.33502 ? 206 MET A N   1 
ATOM   1684 C  CA  . MET A 1 209 ? -27.04663 0.65562   34.29943  1.000 18.72588 ? 206 MET A CA  1 
ATOM   1685 C  C   . MET A 1 209 ? -26.76925 -0.66454  34.98790  1.000 23.64725 ? 206 MET A C   1 
ATOM   1686 O  O   . MET A 1 209 ? -26.12564 -1.55294  34.41732  1.000 21.96230 ? 206 MET A O   1 
ATOM   1687 C  CB  . MET A 1 209 ? -28.22624 0.45943   33.33719  1.000 17.84801 ? 206 MET A CB  1 
ATOM   1688 C  CG  . MET A 1 209 ? -28.66859 1.74437   32.66782  1.000 21.84963 ? 206 MET A CG  1 
ATOM   1689 S  SD  . MET A 1 209 ? -30.08057 1.47602   31.58700  1.000 25.49125 ? 206 MET A SD  1 
ATOM   1690 C  CE  . MET A 1 209 ? -31.41315 1.64588   32.78768  1.000 21.00072 ? 206 MET A CE  1 
ATOM   1691 N  N   . TYR A 1 210 ? -27.26615 -0.80149  36.20813  1.000 19.42216 ? 207 TYR A N   1 
ATOM   1692 C  CA  . TYR A 1 210 ? -27.17102 -2.08274  36.88949  1.000 19.64045 ? 207 TYR A CA  1 
ATOM   1693 C  C   . TYR A 1 210 ? -28.46750 -2.29767  37.64219  1.000 22.43727 ? 207 TYR A C   1 
ATOM   1694 O  O   . TYR A 1 210 ? -29.01665 -1.36203  38.22067  1.000 20.28965 ? 207 TYR A O   1 
ATOM   1695 C  CB  . TYR A 1 210 ? -25.97406 -2.16507  37.85554  1.000 20.36575 ? 207 TYR A CB  1 
ATOM   1696 C  CG  . TYR A 1 210 ? -25.93353 -3.52436  38.52610  1.000 25.67140 ? 207 TYR A CG  1 
ATOM   1697 C  CD1 . TYR A 1 210 ? -25.40988 -4.62474  37.84812  1.000 24.11377 ? 207 TYR A CD1 1 
ATOM   1698 C  CD2 . TYR A 1 210 ? -26.44982 -3.71417  39.80584  1.000 22.74546 ? 207 TYR A CD2 1 
ATOM   1699 C  CE1 . TYR A 1 210 ? -25.39476 -5.86093  38.40899  1.000 24.66936 ? 207 TYR A CE1 1 
ATOM   1700 C  CE2 . TYR A 1 210 ? -26.43082 -4.98204  40.40523  1.000 25.19501 ? 207 TYR A CE2 1 
ATOM   1701 C  CZ  . TYR A 1 210 ? -25.90046 -6.05315  39.68490  1.000 31.60092 ? 207 TYR A CZ  1 
ATOM   1702 O  OH  . TYR A 1 210 ? -25.84965 -7.32904  40.21950  1.000 27.10621 ? 207 TYR A OH  1 
ATOM   1703 N  N   . MET A 1 211 ? -28.98378 -3.50992  37.58369  1.000 20.90778 ? 208 MET A N   1 
ATOM   1704 C  CA  . MET A 1 211 ? -30.22919 -3.85201  38.25027  1.000 24.27775 ? 208 MET A CA  1 
ATOM   1705 C  C   . MET A 1 211 ? -29.90954 -4.87399  39.33151  1.000 28.01037 ? 208 MET A C   1 
ATOM   1706 O  O   . MET A 1 211 ? -29.39298 -5.95650  39.02793  1.000 26.08374 ? 208 MET A O   1 
ATOM   1707 C  CB  . MET A 1 211 ? -31.24170 -4.39922  37.24846  1.000 24.05836 ? 208 MET A CB  1 
ATOM   1708 C  CG  . MET A 1 211 ? -32.41146 -5.12481  37.84687  1.000 33.20249 ? 208 MET A CG  1 
ATOM   1709 S  SD  . MET A 1 211 ? -33.31114 -4.11940  38.99717  1.000 39.35386 ? 208 MET A SD  1 
ATOM   1710 C  CE  . MET A 1 211 ? -34.00854 -2.88800  37.96955  1.000 28.49106 ? 208 MET A CE  1 
ATOM   1711 N  N   . GLY A 1 212 ? -30.17618 -4.51561  40.58526  1.000 23.65704 ? 209 GLY A N   1 
ATOM   1712 C  CA  . GLY A 1 212 ? -29.90994 -5.43460  41.66609  1.000 26.10400 ? 209 GLY A CA  1 
ATOM   1713 C  C   . GLY A 1 212 ? -29.59241 -4.75390  42.97264  1.000 26.11613 ? 209 GLY A C   1 
ATOM   1714 O  O   . GLY A 1 212 ? -29.92615 -5.26878  44.04029  1.000 24.60949 ? 209 GLY A O   1 
ATOM   1715 N  N   . THR A 1 213 ? -28.94099 -3.59958  42.91142  1.000 25.27179 ? 210 THR A N   1 
ATOM   1716 C  CA  . THR A 1 213 ? -28.64106 -2.86915  44.12992  1.000 25.62869 ? 210 THR A CA  1 
ATOM   1717 C  C   . THR A 1 213 ? -28.65614 -1.39057  43.81116  1.000 23.14713 ? 210 THR A C   1 
ATOM   1718 O  O   . THR A 1 213 ? -28.32443 -0.97816  42.69093  1.000 22.72095 ? 210 THR A O   1 
ATOM   1719 C  CB  . THR A 1 213 ? -27.28374 -3.24236  44.75397  1.000 26.38510 ? 210 THR A CB  1 
ATOM   1720 O  OG1 . THR A 1 213 ? -27.06852 -2.44091  45.92237  1.000 29.29351 ? 210 THR A OG1 1 
ATOM   1721 C  CG2 . THR A 1 213 ? -26.14933 -2.97049  43.79949  1.000 23.83815 ? 210 THR A CG2 1 
ATOM   1722 N  N   . LEU A 1 214 ? -29.08218 -0.60625  44.80245  1.000 21.41590 ? 211 LEU A N   1 
ATOM   1723 C  CA  . LEU A 1 214 ? -29.07395 0.85230   44.70131  1.000 22.51731 ? 211 LEU A CA  1 
ATOM   1724 C  C   . LEU A 1 214 ? -27.72775 1.45773   45.05591  1.000 21.34590 ? 211 LEU A C   1 
ATOM   1725 O  O   . LEU A 1 214 ? -27.46777 2.61449   44.70242  1.000 20.68276 ? 211 LEU A O   1 
ATOM   1726 C  CB  . LEU A 1 214 ? -30.11880 1.45799   45.62850  1.000 21.92317 ? 211 LEU A CB  1 
ATOM   1727 C  CG  . LEU A 1 214 ? -31.52898 0.96663   45.40338  1.000 21.43834 ? 211 LEU A CG  1 
ATOM   1728 C  CD1 . LEU A 1 214 ? -32.38991 1.52068   46.51535  1.000 23.45825 ? 211 LEU A CD1 1 
ATOM   1729 C  CD2 . LEU A 1 214 ? -32.05733 1.38740   44.03194  1.000 20.67454 ? 211 LEU A CD2 1 
ATOM   1730 N  N   . SER A 1 215 ? -26.88260 0.71012   45.75478  1.000 24.11532 ? 212 SER A N   1 
ATOM   1731 C  CA  . SER A 1 215 ? -25.67544 1.25418   46.34602  1.000 21.57661 ? 212 SER A CA  1 
ATOM   1732 C  C   . SER A 1 215 ? -24.50857 1.07366   45.38081  1.000 24.48804 ? 212 SER A C   1 
ATOM   1733 O  O   . SER A 1 215 ? -24.13735 -0.05974  45.04498  1.000 22.12001 ? 212 SER A O   1 
ATOM   1734 C  CB  . SER A 1 215 ? -25.38551 0.57315   47.68780  1.000 23.39683 ? 212 SER A CB  1 
ATOM   1735 O  OG  . SER A 1 215 ? -24.12017 0.97115   48.17221  1.000 26.28711 ? 212 SER A OG  1 
ATOM   1736 N  N   . TYR A 1 216 ? -23.92328 2.19160   44.94926  1.000 21.29986 ? 213 TYR A N   1 
ATOM   1737 C  CA  . TYR A 1 216 ? -22.70813 2.11598   44.13976  1.000 24.92270 ? 213 TYR A CA  1 
ATOM   1738 C  C   . TYR A 1 216 ? -21.55120 1.53539   44.95134  1.000 28.72840 ? 213 TYR A C   1 
ATOM   1739 O  O   . TYR A 1 216 ? -20.77407 0.71093   44.44577  1.000 26.13094 ? 213 TYR A O   1 
ATOM   1740 C  CB  . TYR A 1 216 ? -22.36951 3.50709   43.60959  1.000 19.27341 ? 213 TYR A CB  1 
ATOM   1741 C  CG  . TYR A 1 216 ? -21.42151 3.54494   42.43211  1.000 16.50647 ? 213 TYR A CG  1 
ATOM   1742 C  CD1 . TYR A 1 216 ? -21.32224 2.48122   41.54329  1.000 20.67092 ? 213 TYR A CD1 1 
ATOM   1743 C  CD2 . TYR A 1 216 ? -20.62665 4.66328   42.21339  1.000 23.23571 ? 213 TYR A CD2 1 
ATOM   1744 C  CE1 . TYR A 1 216 ? -20.43152 2.53543   40.45848  1.000 21.41222 ? 213 TYR A CE1 1 
ATOM   1745 C  CE2 . TYR A 1 216 ? -19.75424 4.73082   41.14756  1.000 26.54226 ? 213 TYR A CE2 1 
ATOM   1746 C  CZ  . TYR A 1 216 ? -19.66693 3.67681   40.26933  1.000 22.09663 ? 213 TYR A CZ  1 
ATOM   1747 O  OH  . TYR A 1 216 ? -18.79691 3.77225   39.20677  1.000 24.24536 ? 213 TYR A OH  1 
ATOM   1748 N  N   . GLU A 1 217 ? -21.45080 1.93018   46.22485  1.000 24.97530 ? 214 GLU A N   1 
ATOM   1749 C  CA  . GLU A 1 217 ? -20.45183 1.35881   47.12656  1.000 26.71283 ? 214 GLU A CA  1 
ATOM   1750 C  C   . GLU A 1 217 ? -20.58032 -0.16072  47.22235  1.000 27.76190 ? 214 GLU A C   1 
ATOM   1751 O  O   . GLU A 1 217 ? -19.58413 -0.88497  47.12808  1.000 30.29268 ? 214 GLU A O   1 
ATOM   1752 C  CB  . GLU A 1 217 ? -20.59248 1.99190   48.51109  1.000 32.72189 ? 214 GLU A CB  1 
ATOM   1753 C  CG  . GLU A 1 217 ? -19.69730 3.19712   48.71402  1.000 43.88018 ? 214 GLU A CG  1 
ATOM   1754 C  CD  . GLU A 1 217 ? -18.25720 2.86816   48.37469  1.000 51.71174 ? 214 GLU A CD  1 
ATOM   1755 O  OE1 . GLU A 1 217 ? -17.74357 1.83464   48.87407  1.000 50.13956 ? 214 GLU A OE1 1 
ATOM   1756 O  OE2 . GLU A 1 217 ? -17.65846 3.62517   47.57946  1.000 42.16876 ? 214 GLU A OE2 1 
ATOM   1757 N  N   . GLN A 1 218 ? -21.79738 -0.66175  47.44154  1.000 28.61517 ? 215 GLN A N   1 
ATOM   1758 C  CA  . GLN A 1 218 ? -21.98902 -2.11062  47.52383  1.000 27.89972 ? 215 GLN A CA  1 
ATOM   1759 C  C   . GLN A 1 218 ? -21.50001 -2.80337  46.25716  1.000 30.43948 ? 215 GLN A C   1 
ATOM   1760 O  O   . GLN A 1 218 ? -20.86451 -3.86101  46.32040  1.000 30.14362 ? 215 GLN A O   1 
ATOM   1761 C  CB  . GLN A 1 218 ? -23.46392 -2.44215  47.76816  1.000 28.68391 ? 215 GLN A CB  1 
ATOM   1762 C  CG  . GLN A 1 218 ? -23.67745 -3.87206  48.26512  1.000 35.11799 ? 215 GLN A CG  1 
ATOM   1763 C  CD  . GLN A 1 218 ? -22.78800 -4.17175  49.45277  1.000 43.07016 ? 215 GLN A CD  1 
ATOM   1764 O  OE1 . GLN A 1 218 ? -22.93162 -3.55619  50.51216  1.000 51.13190 ? 215 GLN A OE1 1 
ATOM   1765 N  NE2 . GLN A 1 218 ? -21.83052 -5.09384  49.27418  1.000 41.94304 ? 215 GLN A NE2 1 
ATOM   1766 N  N   . PHE A 1 219 ? -21.79457 -2.21145  45.09971  1.000 26.50219 ? 216 PHE A N   1 
ATOM   1767 C  CA  . PHE A 1 219 ? -21.38673 -2.74850  43.80602  1.000 26.12118 ? 216 PHE A CA  1 
ATOM   1768 C  C   . PHE A 1 219 ? -19.86620 -2.77855  43.67392  1.000 24.36659 ? 216 PHE A C   1 
ATOM   1769 O  O   . PHE A 1 219 ? -19.31310 -3.70033  43.06013  1.000 24.98988 ? 216 PHE A O   1 
ATOM   1770 C  CB  . PHE A 1 219 ? -22.04860 -1.88917  42.71959  1.000 22.29832 ? 216 PHE A CB  1 
ATOM   1771 C  CG  . PHE A 1 219 ? -22.02872 -2.47102  41.32635  1.000 24.84679 ? 216 PHE A CG  1 
ATOM   1772 C  CD1 . PHE A 1 219 ? -22.46901 -3.75419  41.07244  1.000 27.18699 ? 216 PHE A CD1 1 
ATOM   1773 C  CD2 . PHE A 1 219 ? -21.65156 -1.67643  40.25820  1.000 27.11710 ? 216 PHE A CD2 1 
ATOM   1774 C  CE1 . PHE A 1 219 ? -22.48046 -4.25130  39.77641  1.000 25.79854 ? 216 PHE A CE1 1 
ATOM   1775 C  CE2 . PHE A 1 219 ? -21.66372 -2.16069  38.96345  1.000 24.58933 ? 216 PHE A CE2 1 
ATOM   1776 C  CZ  . PHE A 1 219 ? -22.08381 -3.44950  38.72192  1.000 28.32122 ? 216 PHE A CZ  1 
ATOM   1777 N  N   . LYS A 1 220 ? -19.17554 -1.79775  44.25678  1.000 24.36952 ? 217 LYS A N   1 
ATOM   1778 C  CA  . LYS A 1 220 ? -17.71644 -1.84419  44.28431  1.000 26.32635 ? 217 LYS A CA  1 
ATOM   1779 C  C   . LYS A 1 220 ? -17.21606 -2.94081  45.21644  1.000 31.71469 ? 217 LYS A C   1 
ATOM   1780 O  O   . LYS A 1 220 ? -16.21859 -3.61339  44.91939  1.000 33.95178 ? 217 LYS A O   1 
ATOM   1781 C  CB  . LYS A 1 220 ? -17.15546 -0.48704  44.70258  1.000 23.54121 ? 217 LYS A CB  1 
ATOM   1782 C  CG  . LYS A 1 220 ? -17.41332 0.60353   43.66532  1.000 24.79709 ? 217 LYS A CG  1 
ATOM   1783 C  CD  . LYS A 1 220 ? -16.90968 1.93912   44.11758  1.000 23.76534 ? 217 LYS A CD  1 
ATOM   1784 C  CE  . LYS A 1 220 ? -17.24444 3.03019   43.10722  1.000 29.56096 ? 217 LYS A CE  1 
ATOM   1785 N  NZ  . LYS A 1 220 ? -16.95802 4.39009   43.62878  1.000 29.86755 ? 217 LYS A NZ  1 
ATOM   1786 N  N   . LYS A 1 221 ? -17.89846 -3.14067  46.34247  1.000 31.15254 ? 218 LYS A N   1 
ATOM   1787 C  CA  . LYS A 1 221 ? -17.49370 -4.17545  47.29216  1.000 28.58095 ? 218 LYS A CA  1 
ATOM   1788 C  C   . LYS A 1 221 ? -17.88908 -5.56521  46.81637  1.000 29.25973 ? 218 LYS A C   1 
ATOM   1789 O  O   . LYS A 1 221 ? -17.13659 -6.52135  47.00467  1.000 34.43647 ? 218 LYS A O   1 
ATOM   1790 C  CB  . LYS A 1 221 ? -18.09936 -3.89399  48.66722  1.000 30.76553 ? 218 LYS A CB  1 
ATOM   1791 C  CG  . LYS A 1 221 ? -17.58836 -2.62129  49.31007  1.000 36.28337 ? 218 LYS A CG  1 
ATOM   1792 C  CD  . LYS A 1 221 ? -18.29542 -2.31123  50.63341  1.000 44.88357 ? 218 LYS A CD  1 
ATOM   1793 C  CE  . LYS A 1 221 ? -17.81528 -0.98261  51.23029  1.000 52.91051 ? 218 LYS A CE  1 
ATOM   1794 N  NZ  . LYS A 1 221 ? -18.63623 -0.55303  52.41053  1.000 54.18336 ? 218 LYS A NZ  1 
ATOM   1795 N  N   . GLY A 1 222 ? -19.06026 -5.70704  46.21977  1.000 26.97170 ? 219 GLY A N   1 
ATOM   1796 C  CA  . GLY A 1 222 ? -19.48180 -7.00319  45.74647  1.000 30.16950 ? 219 GLY A CA  1 
ATOM   1797 C  C   . GLY A 1 222 ? -20.90682 -7.31433  46.13685  1.000 29.11900 ? 219 GLY A C   1 
ATOM   1798 O  O   . GLY A 1 222 ? -21.33078 -6.99760  47.24594  1.000 30.73783 ? 219 GLY A O   1 
ATOM   1799 N  N   . VAL A 1 223 ? -21.65884 -7.91537  45.22303  1.000 23.70978 ? 220 VAL A N   1 
ATOM   1800 C  CA  . VAL A 1 223 ? -23.03676 -8.30400  45.46348  1.000 29.98517 ? 220 VAL A CA  1 
ATOM   1801 C  C   . VAL A 1 223 ? -23.15832 -9.78352  45.13556  1.000 30.97045 ? 220 VAL A C   1 
ATOM   1802 O  O   . VAL A 1 223 ? -22.45263 -10.30377 44.26584  1.000 36.16241 ? 220 VAL A O   1 
ATOM   1803 C  CB  . VAL A 1 223 ? -24.02688 -7.45484  44.63077  1.000 28.72269 ? 220 VAL A CB  1 
ATOM   1804 C  CG1 . VAL A 1 223 ? -23.97311 -6.01554  45.08662  1.000 31.69608 ? 220 VAL A CG1 1 
ATOM   1805 C  CG2 . VAL A 1 223 ? -23.70050 -7.54044  43.12746  1.000 26.57959 ? 220 VAL A CG2 1 
ATOM   1806 N  N   . GLN A 1 224 ? -24.05013 -10.46183 45.84922  1.000 33.00043 ? 221 GLN A N   1 
ATOM   1807 C  CA  . GLN A 1 224 ? -24.25748 -11.89311 45.68851  1.000 31.18398 ? 221 GLN A CA  1 
ATOM   1808 C  C   . GLN A 1 224 ? -25.23256 -12.14300 44.55683  1.000 33.19329 ? 221 GLN A C   1 
ATOM   1809 O  O   . GLN A 1 224 ? -26.30805 -11.54308 44.51599  1.000 34.41760 ? 221 GLN A O   1 
ATOM   1810 C  CB  . GLN A 1 224 ? -24.79909 -12.50384 46.98310  1.000 39.34518 ? 221 GLN A CB  1 
ATOM   1811 C  CG  . GLN A 1 224 ? -23.88512 -12.30002 48.14545  1.000 33.07972 ? 221 GLN A CG  1 
ATOM   1812 C  CD  . GLN A 1 224 ? -22.49632 -12.75707 47.82502  1.000 41.77541 ? 221 GLN A CD  1 
ATOM   1813 O  OE1 . GLN A 1 224 ? -21.57123 -11.94656 47.71656  1.000 46.02732 ? 221 GLN A OE1 1 
ATOM   1814 N  NE2 . GLN A 1 224 ? -22.33202 -14.06901 47.65622  1.000 41.74449 ? 221 GLN A NE2 1 
ATOM   1815 N  N   . ILE A 1 225 ? -24.86108 -13.03462 43.64801  1.000 27.61562 ? 222 ILE A N   1 
ATOM   1816 C  CA  . ILE A 1 225 ? -25.73994 -13.43430 42.55254  1.000 37.45320 ? 222 ILE A CA  1 
ATOM   1817 C  C   . ILE A 1 225 ? -25.62621 -14.93802 42.36855  1.000 32.44092 ? 222 ILE A C   1 
ATOM   1818 O  O   . ILE A 1 225 ? -24.63247 -15.55283 42.77575  1.000 32.41091 ? 222 ILE A O   1 
ATOM   1819 C  CB  . ILE A 1 225 ? -25.38839 -12.71168 41.23467  1.000 34.81739 ? 222 ILE A CB  1 
ATOM   1820 C  CG1 . ILE A 1 225 ? -23.95001 -13.04344 40.81319  1.000 36.05731 ? 222 ILE A CG1 1 
ATOM   1821 C  CG2 . ILE A 1 225 ? -25.59979 -11.20154 41.36798  1.000 27.80997 ? 222 ILE A CG2 1 
ATOM   1822 C  CD1 . ILE A 1 225 ? -23.65802 -12.73293 39.36053  1.000 31.10808 ? 222 ILE A CD1 1 
ATOM   1823 N  N   . PRO A 1 226 ? -26.63703 -15.56164 41.77228  1.000 36.41017 ? 223 PRO A N   1 
ATOM   1824 C  CA  . PRO A 1 226 ? -26.54659 -17.00720 41.52252  1.000 37.07967 ? 223 PRO A CA  1 
ATOM   1825 C  C   . PRO A 1 226 ? -25.41323 -17.35639 40.56534  1.000 34.97638 ? 223 PRO A C   1 
ATOM   1826 O  O   . PRO A 1 226 ? -25.07028 -16.59546 39.66218  1.000 35.71991 ? 223 PRO A O   1 
ATOM   1827 C  CB  . PRO A 1 226 ? -27.91954 -17.36062 40.92281  1.000 32.74480 ? 223 PRO A CB  1 
ATOM   1828 C  CG  . PRO A 1 226 ? -28.59739 -16.06586 40.63560  1.000 38.32234 ? 223 PRO A CG  1 
ATOM   1829 C  CD  . PRO A 1 226 ? -27.99916 -15.04652 41.55430  1.000 31.64060 ? 223 PRO A CD  1 
ATOM   1830 N  N   . CYS A 1 227 ? -24.81253 -18.52178 40.79121  1.000 37.98178 ? 224 CYS A N   1 
ATOM   1831 C  CA  . CYS A 1 227 ? -23.89193 -19.13843 39.84677  1.000 28.16159 ? 224 CYS A CA  1 
ATOM   1832 C  C   . CYS A 1 227 ? -24.53999 -20.39348 39.26654  1.000 35.16286 ? 224 CYS A C   1 
ATOM   1833 O  O   . CYS A 1 227 ? -25.40315 -21.00732 39.90382  1.000 34.78999 ? 224 CYS A O   1 
ATOM   1834 C  CB  . CYS A 1 227 ? -22.56350 -19.48401 40.53031  1.000 28.51625 ? 224 CYS A CB  1 
ATOM   1835 S  SG  . CYS A 1 227 ? -21.40175 -20.31900 39.43447  1.000 33.76435 ? 224 CYS A SG  1 
ATOM   1836 N  N   . THR A 1 228 ? -24.12699 -20.78069 38.04989  1.000 35.04840 ? 225 THR A N   1 
ATOM   1837 C  CA  . THR A 1 228 ? -24.73634 -21.95207 37.41528  1.000 38.94989 ? 225 THR A CA  1 
ATOM   1838 C  C   . THR A 1 228 ? -24.51144 -23.22915 38.21395  1.000 44.52527 ? 225 THR A C   1 
ATOM   1839 O  O   . THR A 1 228 ? -25.26335 -24.19389 38.04232  1.000 42.08439 ? 225 THR A O   1 
ATOM   1840 C  CB  . THR A 1 228 ? -24.19754 -22.16728 35.99843  1.000 42.18497 ? 225 THR A CB  1 
ATOM   1841 O  OG1 . THR A 1 228 ? -22.76190 -22.19680 36.03451  1.000 45.27420 ? 225 THR A OG1 1 
ATOM   1842 C  CG2 . THR A 1 228 ? -24.66782 -21.06030 35.06805  1.000 46.41406 ? 225 THR A CG2 1 
ATOM   1843 N  N   . CYS A 1 229 ? -23.48714 -23.27028 39.06755  1.000 38.53202 ? 226 CYS A N   1 
ATOM   1844 C  CA  . CYS A 1 229 ? -23.26892 -24.44200 39.90647  1.000 36.41731 ? 226 CYS A CA  1 
ATOM   1845 C  C   . CYS A 1 229 ? -24.23620 -24.51311 41.07563  1.000 36.55706 ? 226 CYS A C   1 
ATOM   1846 O  O   . CYS A 1 229 ? -24.26921 -25.53272 41.77395  1.000 39.78220 ? 226 CYS A O   1 
ATOM   1847 C  CB  . CYS A 1 229 ? -21.84312 -24.44814 40.45242  1.000 34.73436 ? 226 CYS A CB  1 
ATOM   1848 S  SG  . CYS A 1 229 ? -21.62100 -23.25911 41.78206  1.000 34.48533 ? 226 CYS A SG  1 
ATOM   1849 N  N   . GLY A 1 230 ? -25.01509 -23.46488 41.31756  1.000 34.65996 ? 227 GLY A N   1 
ATOM   1850 C  CA  . GLY A 1 230 ? -25.95462 -23.44471 42.40923  1.000 32.07324 ? 227 GLY A CA  1 
ATOM   1851 C  C   . GLY A 1 230 ? -25.51578 -22.60950 43.59163  1.000 32.59795 ? 227 GLY A C   1 
ATOM   1852 O  O   . GLY A 1 230 ? -26.37201 -22.16992 44.36789  1.000 31.67909 ? 227 GLY A O   1 
ATOM   1853 N  N   . LYS A 1 231 ? -24.21005 -22.38417 43.75258  1.000 27.05904 ? 228 LYS A N   1 
ATOM   1854 C  CA  . LYS A 1 231 ? -23.74284 -21.50490 44.81021  1.000 33.30231 ? 228 LYS A CA  1 
ATOM   1855 C  C   . LYS A 1 231 ? -24.11854 -20.06272 44.47732  1.000 36.06962 ? 228 LYS A C   1 
ATOM   1856 O  O   . LYS A 1 231 ? -24.54745 -19.74062 43.36422  1.000 30.70615 ? 228 LYS A O   1 
ATOM   1857 C  CB  . LYS A 1 231 ? -22.22339 -21.62555 45.00420  1.000 33.21405 ? 228 LYS A CB  1 
ATOM   1858 C  CG  . LYS A 1 231 ? -21.73356 -23.02511 45.42540  1.000 37.18667 ? 228 LYS A CG  1 
ATOM   1859 C  CD  . LYS A 1 231 ? -20.34188 -22.99892 46.07401  1.000 35.51505 ? 228 LYS A CD  1 
ATOM   1860 C  CE  . LYS A 1 231 ? -20.32652 -22.09338 47.29311  1.000 39.33494 ? 228 LYS A CE  1 
ATOM   1861 N  NZ  . LYS A 1 231 ? -21.14611 -22.62267 48.43353  1.000 43.45679 ? 228 LYS A NZ  1 
ATOM   1862 N  N   . GLN A 1 232 ? -23.96283 -19.19166 45.46205  1.000 31.63253 ? 229 GLN A N   1 
ATOM   1863 C  CA  . GLN A 1 232 ? -23.96854 -17.76143 45.20995  1.000 36.53952 ? 229 GLN A CA  1 
ATOM   1864 C  C   . GLN A 1 232 ? -22.53988 -17.30361 44.95929  1.000 38.22464 ? 229 GLN A C   1 
ATOM   1865 O  O   . GLN A 1 232 ? -21.61905 -17.68774 45.68740  1.000 34.54775 ? 229 GLN A O   1 
ATOM   1866 C  CB  . GLN A 1 232 ? -24.60028 -16.99865 46.37532  1.000 36.74215 ? 229 GLN A CB  1 
ATOM   1867 C  CG  . GLN A 1 232 ? -26.11447 -17.18193 46.39050  1.000 39.39653 ? 229 GLN A CG  1 
ATOM   1868 C  CD  . GLN A 1 232 ? -26.80293 -16.39094 47.46898  1.000 49.28999 ? 229 GLN A CD  1 
ATOM   1869 O  OE1 . GLN A 1 232 ? -26.23304 -15.44554 48.02711  1.000 49.68144 ? 229 GLN A OE1 1 
ATOM   1870 N  NE2 . GLN A 1 232 ? -28.05002 -16.77273 47.77816  1.000 50.03051 ? 229 GLN A NE2 1 
ATOM   1871 N  N   . ALA A 1 233 ? -22.36074 -16.52768 43.89875  1.000 32.72165 ? 230 ALA A N   1 
ATOM   1872 C  CA  . ALA A 1 233 ? -21.08724 -15.92510 43.54377  1.000 30.26558 ? 230 ALA A CA  1 
ATOM   1873 C  C   . ALA A 1 233 ? -21.09640 -14.44273 43.90426  1.000 31.24532 ? 230 ALA A C   1 
ATOM   1874 O  O   . ALA A 1 233 ? -22.13205 -13.85766 44.23291  1.000 35.30091 ? 230 ALA A O   1 
ATOM   1875 C  CB  . ALA A 1 233 ? -20.81163 -16.11154 42.05274  1.000 31.27317 ? 230 ALA A CB  1 
ATOM   1876 N  N   . THR A 1 234 ? -19.92166 -13.83237 43.83845  1.000 30.05857 ? 231 THR A N   1 
ATOM   1877 C  CA  . THR A 1 234 ? -19.76623 -12.42567 44.17299  1.000 33.02601 ? 231 THR A CA  1 
ATOM   1878 C  C   . THR A 1 234 ? -19.41434 -11.66282 42.90973  1.000 32.68217 ? 231 THR A C   1 
ATOM   1879 O  O   . THR A 1 234 ? -18.44677 -12.00105 42.21461  1.000 27.84547 ? 231 THR A O   1 
ATOM   1880 C  CB  . THR A 1 234 ? -18.69608 -12.21547 45.23888  1.000 40.17672 ? 231 THR A CB  1 
ATOM   1881 O  OG1 . THR A 1 234 ? -19.09101 -12.88758 46.44113  1.000 34.20748 ? 231 THR A OG1 1 
ATOM   1882 C  CG2 . THR A 1 234 ? -18.53993 -10.72830 45.51833  1.000 37.53782 ? 231 THR A CG2 1 
ATOM   1883 N  N   . LYS A 1 235 ? -20.22217 -10.66347 42.59329  1.000 29.33387 ? 232 LYS A N   1 
ATOM   1884 C  CA  . LYS A 1 235 ? -19.98203 -9.80344  41.44719  1.000 30.29666 ? 232 LYS A CA  1 
ATOM   1885 C  C   . LYS A 1 235 ? -19.54451 -8.44941  41.97369  1.000 26.93268 ? 232 LYS A C   1 
ATOM   1886 O  O   . LYS A 1 235 ? -20.21874 -7.88078  42.83790  1.000 34.41559 ? 232 LYS A O   1 
ATOM   1887 C  CB  . LYS A 1 235 ? -21.24533 -9.67573  40.59312  1.000 25.05590 ? 232 LYS A CB  1 
ATOM   1888 C  CG  . LYS A 1 235 ? -21.19975 -8.57281  39.55128  1.000 26.51223 ? 232 LYS A CG  1 
ATOM   1889 C  CD  . LYS A 1 235 ? -22.52523 -8.52472  38.78304  1.000 28.42013 ? 232 LYS A CD  1 
ATOM   1890 C  CE  . LYS A 1 235 ? -22.47051 -9.43544  37.57368  1.000 28.51944 ? 232 LYS A CE  1 
ATOM   1891 N  NZ  . LYS A 1 235 ? -23.78193 -9.52492  36.87128  1.000 28.88165 ? 232 LYS A NZ  1 
ATOM   1892 N  N   . TYR A 1 236 ? -18.42267 -7.93541  41.46769  1.000 28.22189 ? 233 TYR A N   1 
ATOM   1893 C  CA  . TYR A 1 236 ? -17.97667 -6.61322  41.87703  1.000 24.14159 ? 233 TYR A CA  1 
ATOM   1894 C  C   . TYR A 1 236 ? -17.42417 -5.83377  40.68755  1.000 29.23220 ? 233 TYR A C   1 
ATOM   1895 O  O   . TYR A 1 236 ? -17.01402 -6.39034  39.66335  1.000 25.65814 ? 233 TYR A O   1 
ATOM   1896 C  CB  . TYR A 1 236 ? -16.94668 -6.67169  43.00532  1.000 34.28177 ? 233 TYR A CB  1 
ATOM   1897 C  CG  . TYR A 1 236 ? -15.62493 -7.27982  42.61810  1.000 31.57459 ? 233 TYR A CG  1 
ATOM   1898 C  CD1 . TYR A 1 236 ? -15.44342 -8.66426  42.62769  1.000 35.77885 ? 233 TYR A CD1 1 
ATOM   1899 C  CD2 . TYR A 1 236 ? -14.54763 -6.47899  42.28330  1.000 31.97674 ? 233 TYR A CD2 1 
ATOM   1900 C  CE1 . TYR A 1 236 ? -14.22443 -9.23333  42.27577  1.000 34.30577 ? 233 TYR A CE1 1 
ATOM   1901 C  CE2 . TYR A 1 236 ? -13.31660 -7.03930  41.93861  1.000 31.75132 ? 233 TYR A CE2 1 
ATOM   1902 C  CZ  . TYR A 1 236 ? -13.16920 -8.41451  41.93862  1.000 35.94296 ? 233 TYR A CZ  1 
ATOM   1903 O  OH  . TYR A 1 236 ? -11.96868 -8.96373  41.58878  1.000 35.29787 ? 233 TYR A OH  1 
ATOM   1904 N  N   . LEU A 1 237 ? -17.45229 -4.51867  40.84986  1.000 28.16523 ? 234 LEU A N   1 
ATOM   1905 C  CA  . LEU A 1 237 ? -17.00759 -3.57734  39.83520  1.000 23.46090 ? 234 LEU A CA  1 
ATOM   1906 C  C   . LEU A 1 237 ? -15.48924 -3.50784  39.81821  1.000 25.38076 ? 234 LEU A C   1 
ATOM   1907 O  O   . LEU A 1 237 ? -14.87841 -3.18688  40.84014  1.000 26.81299 ? 234 LEU A O   1 
ATOM   1908 C  CB  . LEU A 1 237 ? -17.58758 -2.20516  40.14085  1.000 25.38356 ? 234 LEU A CB  1 
ATOM   1909 C  CG  . LEU A 1 237 ? -17.21789 -1.07453  39.19795  1.000 28.27238 ? 234 LEU A CG  1 
ATOM   1910 C  CD1 . LEU A 1 237 ? -17.74113 -1.42823  37.85191  1.000 19.82144 ? 234 LEU A CD1 1 
ATOM   1911 C  CD2 . LEU A 1 237 ? -17.85538 0.20627   39.70829  1.000 18.83575 ? 234 LEU A CD2 1 
ATOM   1912 N  N   . VAL A 1 238 ? -14.88747 -3.80380  38.66930  1.000 23.75372 ? 235 VAL A N   1 
ATOM   1913 C  CA  . VAL A 1 238 ? -13.43172 -3.72110  38.51010  1.000 28.69324 ? 235 VAL A CA  1 
ATOM   1914 C  C   . VAL A 1 238 ? -13.01252 -2.36711  37.97290  1.000 31.01351 ? 235 VAL A C   1 
ATOM   1915 O  O   . VAL A 1 238 ? -12.03096 -1.77369  38.42627  1.000 29.34338 ? 235 VAL A O   1 
ATOM   1916 C  CB  . VAL A 1 238 ? -12.92472 -4.84813  37.57997  1.000 29.97361 ? 235 VAL A CB  1 
ATOM   1917 C  CG1 . VAL A 1 238 ? -11.43236 -4.65768  37.28586  1.000 29.39699 ? 235 VAL A CG1 1 
ATOM   1918 C  CG2 . VAL A 1 238 ? -13.19138 -6.21357  38.18258  1.000 30.50316 ? 235 VAL A CG2 1 
ATOM   1919 N  N   . GLN A 1 239 ? -13.71760 -1.87605  36.96030  1.000 25.85516 ? 236 GLN A N   1 
ATOM   1920 C  CA  . GLN A 1 239 ? -13.31895 -0.63868  36.31061  1.000 26.85274 ? 236 GLN A CA  1 
ATOM   1921 C  C   . GLN A 1 239 ? -14.56093 0.03661   35.74529  1.000 25.13624 ? 236 GLN A C   1 
ATOM   1922 O  O   . GLN A 1 239 ? -15.43729 -0.63073  35.18464  1.000 27.36356 ? 236 GLN A O   1 
ATOM   1923 C  CB  . GLN A 1 239 ? -12.31059 -0.91077  35.19211  1.000 23.01227 ? 236 GLN A CB  1 
ATOM   1924 C  CG  . GLN A 1 239 ? -11.11412 -0.00949  35.21488  1.000 45.20158 ? 236 GLN A CG  1 
ATOM   1925 C  CD  . GLN A 1 239 ? -11.15242 1.01036   34.11417  1.000 50.06344 ? 236 GLN A CD  1 
ATOM   1926 O  OE1 . GLN A 1 239 ? -11.12155 0.66302   32.93273  1.000 58.29426 ? 236 GLN A OE1 1 
ATOM   1927 N  NE2 . GLN A 1 239 ? -11.21971 2.28931   34.48985  1.000 53.67382 ? 236 GLN A NE2 1 
ATOM   1928 N  N   . GLN A 1 240 ? -14.62560 1.35951   35.88201  1.000 25.75227 ? 237 GLN A N   1 
ATOM   1929 C  CA  . GLN A 1 240 ? -15.75702 2.11298   35.36079  1.000 23.93787 ? 237 GLN A CA  1 
ATOM   1930 C  C   . GLN A 1 240 ? -15.25455 3.37595   34.68079  1.000 24.02003 ? 237 GLN A C   1 
ATOM   1931 O  O   . GLN A 1 240 ? -14.47078 4.11988   35.26986  1.000 28.38473 ? 237 GLN A O   1 
ATOM   1932 C  CB  . GLN A 1 240 ? -16.73279 2.47474   36.48336  1.000 20.63597 ? 237 GLN A CB  1 
ATOM   1933 C  CG  . GLN A 1 240 ? -17.95831 3.22463   36.01859  1.000 21.23744 ? 237 GLN A CG  1 
ATOM   1934 C  CD  . GLN A 1 240 ? -18.89611 2.31953   35.24943  1.000 24.33212 ? 237 GLN A CD  1 
ATOM   1935 O  OE1 . GLN A 1 240 ? -18.94592 1.10724   35.50053  1.000 22.93640 ? 237 GLN A OE1 1 
ATOM   1936 N  NE2 . GLN A 1 240 ? -19.64290 2.88953   34.30708  1.000 20.48125 ? 237 GLN A NE2 1 
ATOM   1937 N  N   . GLU A 1 241 ? -15.71136 3.61255   33.45443  1.000 21.93328 ? 238 GLU A N   1 
ATOM   1938 C  CA  . GLU A 1 241 ? -15.41652 4.82780   32.68739  1.000 23.04228 ? 238 GLU A CA  1 
ATOM   1939 C  C   . GLU A 1 241 ? -16.76656 5.32607   32.20055  1.000 22.70620 ? 238 GLU A C   1 
ATOM   1940 O  O   . GLU A 1 241 ? -17.31782 4.75218   31.26005  1.000 20.43166 ? 238 GLU A O   1 
ATOM   1941 C  CB  . GLU A 1 241 ? -14.49723 4.56040   31.49499  1.000 28.79128 ? 238 GLU A CB  1 
ATOM   1942 C  CG  . GLU A 1 241 ? -13.12656 4.01651   31.82367  1.000 35.87369 ? 238 GLU A CG  1 
ATOM   1943 C  CD  . GLU A 1 241 ? -12.24402 5.07181   32.44243  1.000 48.65937 ? 238 GLU A CD  1 
ATOM   1944 O  OE1 . GLU A 1 241 ? -12.35527 6.25297   32.03481  1.000 51.68661 ? 238 GLU A OE1 1 
ATOM   1945 O  OE2 . GLU A 1 241 ? -11.45342 4.72520   33.34582  1.000 54.01946 ? 238 GLU A OE2 1 
ATOM   1946 N  N   . SER A 1 242 ? -17.29767 6.35875   32.84125  1.000 18.77875 ? 239 SER A N   1 
ATOM   1947 C  CA  . SER A 1 242 ? -18.57562 6.94369   32.45111  1.000 20.59313 ? 239 SER A CA  1 
ATOM   1948 C  C   . SER A 1 242 ? -18.76005 8.22991   33.23988  1.000 23.61755 ? 239 SER A C   1 
ATOM   1949 O  O   . SER A 1 242 ? -18.16172 8.38585   34.30182  1.000 23.64359 ? 239 SER A O   1 
ATOM   1950 C  CB  . SER A 1 242 ? -19.74306 5.98112   32.72976  1.000 19.72568 ? 239 SER A CB  1 
ATOM   1951 O  OG  . SER A 1 242 ? -19.79586 5.67825   34.11781  1.000 18.16361 ? 239 SER A OG  1 
ATOM   1952 N  N   . PRO A 1 243 ? -19.57934 9.16290   32.73700  1.000 22.59227 ? 240 PRO A N   1 
ATOM   1953 C  CA  . PRO A 1 243 ? -19.84473 10.40101  33.49349  1.000 20.81573 ? 240 PRO A CA  1 
ATOM   1954 C  C   . PRO A 1 243 ? -20.89325 10.25381  34.57766  1.000 22.25538 ? 240 PRO A C   1 
ATOM   1955 O  O   . PRO A 1 243 ? -21.03374 11.16328  35.40619  1.000 23.03993 ? 240 PRO A O   1 
ATOM   1956 C  CB  . PRO A 1 243 ? -20.32061 11.38572  32.40354  1.000 22.71996 ? 240 PRO A CB  1 
ATOM   1957 C  CG  . PRO A 1 243 ? -20.94263 10.50094  31.36248  1.000 23.62778 ? 240 PRO A CG  1 
ATOM   1958 C  CD  . PRO A 1 243 ? -20.12041 9.21089   31.36594  1.000 18.20216 ? 240 PRO A CD  1 
ATOM   1959 N  N   . PHE A 1 244 ? -21.64240 9.15346   34.58728  1.000 16.49741 ? 241 PHE A N   1 
ATOM   1960 C  CA  . PHE A 1 244 ? -22.58542 8.86518   35.64543  1.000 17.53909 ? 241 PHE A CA  1 
ATOM   1961 C  C   . PHE A 1 244 ? -22.73204 7.35825   35.68690  1.000 18.79505 ? 241 PHE A C   1 
ATOM   1962 O  O   . PHE A 1 244 ? -22.28104 6.65609   34.78400  1.000 19.31730 ? 241 PHE A O   1 
ATOM   1963 C  CB  . PHE A 1 244 ? -23.94592 9.53626   35.39623  1.000 18.87561 ? 241 PHE A CB  1 
ATOM   1964 C  CG  . PHE A 1 244 ? -24.63017 9.05195   34.13671  1.000 18.64379 ? 241 PHE A CG  1 
ATOM   1965 C  CD1 . PHE A 1 244 ? -24.39455 9.67471   32.92336  1.000 20.57424 ? 241 PHE A CD1 1 
ATOM   1966 C  CD2 . PHE A 1 244 ? -25.51279 7.98153   34.17756  1.000 21.58438 ? 241 PHE A CD2 1 
ATOM   1967 C  CE1 . PHE A 1 244 ? -25.01163 9.22561   31.75309  1.000 17.69032 ? 241 PHE A CE1 1 
ATOM   1968 C  CE2 . PHE A 1 244 ? -26.12884 7.52213   33.02058  1.000 19.42637 ? 241 PHE A CE2 1 
ATOM   1969 C  CZ  . PHE A 1 244 ? -25.87592 8.14726   31.80125  1.000 17.49779 ? 241 PHE A CZ  1 
ATOM   1970 N  N   . VAL A 1 245 ? -23.36266 6.85603   36.74583  1.000 18.81218 ? 242 VAL A N   1 
ATOM   1971 C  CA  . VAL A 1 245 ? -23.86596 5.49007   36.74602  1.000 15.38888 ? 242 VAL A CA  1 
ATOM   1972 C  C   . VAL A 1 245 ? -25.27025 5.52707   37.33082  1.000 18.14192 ? 242 VAL A C   1 
ATOM   1973 O  O   . VAL A 1 245 ? -25.61646 6.42005   38.10097  1.000 21.23516 ? 242 VAL A O   1 
ATOM   1974 C  CB  . VAL A 1 245 ? -22.97061 4.50496   37.53436  1.000 21.18385 ? 242 VAL A CB  1 
ATOM   1975 C  CG1 . VAL A 1 245 ? -21.56788 4.39815   36.89894  1.000 21.79744 ? 242 VAL A CG1 1 
ATOM   1976 C  CG2 . VAL A 1 245 ? -22.86724 4.92278   39.00048  1.000 21.14012 ? 242 VAL A CG2 1 
ATOM   1977 N  N   . MET A 1 246 ? -26.06990 4.52996   36.96803  1.000 15.35216 ? 243 MET A N   1 
ATOM   1978 C  CA  . MET A 1 246 ? -27.44307 4.39204   37.43884  1.000 18.13323 ? 243 MET A CA  1 
ATOM   1979 C  C   . MET A 1 246 ? -27.58518 3.03454   38.10616  1.000 18.68235 ? 243 MET A C   1 
ATOM   1980 O  O   . MET A 1 246 ? -27.38498 2.00114   37.46186  1.000 19.96314 ? 243 MET A O   1 
ATOM   1981 C  CB  . MET A 1 246 ? -28.43186 4.54586   36.27441  1.000 16.36320 ? 243 MET A CB  1 
ATOM   1982 C  CG  . MET A 1 246 ? -29.89911 4.27522   36.64399  1.000 18.54512 ? 243 MET A CG  1 
ATOM   1983 S  SD  . MET A 1 246 ? -31.00285 4.41375   35.23356  1.000 21.67542 ? 243 MET A SD  1 
ATOM   1984 C  CE  . MET A 1 246 ? -32.61327 4.28954   36.05497  1.000 15.16115 ? 243 MET A CE  1 
ATOM   1985 N  N   . MET A 1 247 ? -27.91501 3.02880   39.39120  1.000 19.68889 ? 244 MET A N   1 
ATOM   1986 C  CA  . MET A 1 247 ? -28.07317 1.79252   40.14513  1.000 17.90324 ? 244 MET A CA  1 
ATOM   1987 C  C   . MET A 1 247 ? -29.55475 1.60101   40.44097  1.000 19.22444 ? 244 MET A C   1 
ATOM   1988 O  O   . MET A 1 247 ? -30.18591 2.49704   40.99168  1.000 20.97526 ? 244 MET A O   1 
ATOM   1989 C  CB  . MET A 1 247 ? -27.26844 1.84257   41.44855  1.000 16.06460 ? 244 MET A CB  1 
ATOM   1990 C  CG  . MET A 1 247 ? -25.78577 2.17946   41.26554  1.000 20.68511 ? 244 MET A CG  1 
ATOM   1991 S  SD  . MET A 1 247 ? -24.87416 0.89740   40.37628  1.000 23.43847 ? 244 MET A SD  1 
ATOM   1992 C  CE  . MET A 1 247 ? -25.24066 -0.47103  41.44268  1.000 17.74326 ? 244 MET A CE  1 
ATOM   1993 N  N   . SER A 1 248 ? -30.10710 0.44251   40.08760  1.000 19.30793 ? 245 SER A N   1 
ATOM   1994 C  CA  . SER A 1 248 ? -31.55213 0.26491   40.16490  1.000 19.71296 ? 245 SER A CA  1 
ATOM   1995 C  C   . SER A 1 248 ? -31.88089 -1.02260  40.90051  1.000 21.16243 ? 245 SER A C   1 
ATOM   1996 O  O   . SER A 1 248 ? -31.08418 -1.96646  40.91217  1.000 19.60333 ? 245 SER A O   1 
ATOM   1997 C  CB  . SER A 1 248 ? -32.20897 0.26711   38.75980  1.000 18.92569 ? 245 SER A CB  1 
ATOM   1998 O  OG  . SER A 1 248 ? -32.01909 1.51728   38.08266  1.000 20.52767 ? 245 SER A OG  1 
ATOM   1999 N  N   . ALA A 1 249 ? -33.06865 -1.05903  41.50472  1.000 20.86560 ? 246 ALA A N   1 
ATOM   2000 C  CA  . ALA A 1 249 ? -33.50799 -2.24702  42.23083  1.000 21.10096 ? 246 ALA A CA  1 
ATOM   2001 C  C   . ALA A 1 249 ? -35.02086 -2.16511  42.42458  1.000 29.33418 ? 246 ALA A C   1 
ATOM   2002 O  O   . ALA A 1 249 ? -35.60853 -1.07686  42.31709  1.000 22.64771 ? 246 ALA A O   1 
ATOM   2003 C  CB  . ALA A 1 249 ? -32.79034 -2.36648  43.58594  1.000 26.06100 ? 246 ALA A CB  1 
ATOM   2004 N  N   . PRO A 1 250 ? -35.68401 -3.29004  42.68983  1.000 23.86573 ? 247 PRO A N   1 
ATOM   2005 C  CA  . PRO A 1 250 ? -37.10150 -3.21991  43.09248  1.000 24.86195 ? 247 PRO A CA  1 
ATOM   2006 C  C   . PRO A 1 250 ? -37.25952 -2.29120  44.28445  1.000 24.26982 ? 247 PRO A C   1 
ATOM   2007 O  O   . PRO A 1 250 ? -36.34946 -2.18269  45.12222  1.000 26.82458 ? 247 PRO A O   1 
ATOM   2008 C  CB  . PRO A 1 250 ? -37.44936 -4.67390  43.45413  1.000 27.55459 ? 247 PRO A CB  1 
ATOM   2009 C  CG  . PRO A 1 250 ? -36.46760 -5.50995  42.66306  1.000 24.44907 ? 247 PRO A CG  1 
ATOM   2010 C  CD  . PRO A 1 250 ? -35.18271 -4.67971  42.64798  1.000 25.67312 ? 247 PRO A CD  1 
ATOM   2011 N  N   . PRO A 1 251 ? -38.39331 -1.59969  44.40001  1.000 24.55269 ? 248 PRO A N   1 
ATOM   2012 C  CA  . PRO A 1 251 ? -38.53949 -0.59805  45.46884  1.000 20.96159 ? 248 PRO A CA  1 
ATOM   2013 C  C   . PRO A 1 251 ? -38.31922 -1.20975  46.84252  1.000 28.14061 ? 248 PRO A C   1 
ATOM   2014 O  O   . PRO A 1 251 ? -38.92554 -2.21569  47.19780  1.000 25.93517 ? 248 PRO A O   1 
ATOM   2015 C  CB  . PRO A 1 251 ? -39.98038 -0.10424  45.31243  1.000 24.31555 ? 248 PRO A CB  1 
ATOM   2016 C  CG  . PRO A 1 251 ? -40.45844 -0.60360  44.01614  1.000 21.07082 ? 248 PRO A CG  1 
ATOM   2017 C  CD  . PRO A 1 251 ? -39.62435 -1.78372  43.61893  1.000 24.67559 ? 248 PRO A CD  1 
ATOM   2018 N  N   . ALA A 1 252 ? -37.45432 -0.58107  47.62058  1.000 26.29387 ? 249 ALA A N   1 
ATOM   2019 C  CA  . ALA A 1 252 ? -37.16339 -1.03989  48.96500  1.000 30.96342 ? 249 ALA A CA  1 
ATOM   2020 C  C   . ALA A 1 252 ? -36.86156 0.19108   49.80180  1.000 29.29480 ? 249 ALA A C   1 
ATOM   2021 O  O   . ALA A 1 252 ? -36.27085 1.15234   49.29273  1.000 25.97530 ? 249 ALA A O   1 
ATOM   2022 C  CB  . ALA A 1 252 ? -35.96840 -2.00719  48.98550  1.000 27.12168 ? 249 ALA A CB  1 
ATOM   2023 N  N   . GLN A 1 253 ? -37.27763 0.15841   51.07224  1.000 27.47165 ? 250 GLN A N   1 
ATOM   2024 C  CA  . GLN A 1 253 ? -36.87240 1.19306   52.01724  1.000 30.19795 ? 250 GLN A CA  1 
ATOM   2025 C  C   . GLN A 1 253 ? -35.36561 1.35219   51.99137  1.000 26.52655 ? 250 GLN A C   1 
ATOM   2026 O  O   . GLN A 1 253 ? -34.61672 0.37278   52.06689  1.000 26.48613 ? 250 GLN A O   1 
ATOM   2027 C  CB  . GLN A 1 253 ? -37.33649 0.85588   53.43153  1.000 30.21373 ? 250 GLN A CB  1 
ATOM   2028 C  CG  . GLN A 1 253 ? -38.82265 0.92538   53.57831  1.000 37.32096 ? 250 GLN A CG  1 
ATOM   2029 C  CD  . GLN A 1 253 ? -39.35982 2.29206   53.22426  1.000 34.62838 ? 250 GLN A CD  1 
ATOM   2030 O  OE1 . GLN A 1 253 ? -38.85071 3.31151   53.69531  1.000 36.99543 ? 250 GLN A OE1 1 
ATOM   2031 N  NE2 . GLN A 1 253 ? -40.38501 2.32339   52.37901  1.000 38.03963 ? 250 GLN A NE2 1 
ATOM   2032 N  N   . TYR A 1 254 ? -34.92843 2.59471   51.85215  1.000 27.96572 ? 251 TYR A N   1 
ATOM   2033 C  CA  . TYR A 1 254 ? -33.53593 2.88478   51.58411  1.000 22.66905 ? 251 TYR A CA  1 
ATOM   2034 C  C   . TYR A 1 254 ? -33.25536 4.29585   52.06681  1.000 26.13418 ? 251 TYR A C   1 
ATOM   2035 O  O   . TYR A 1 254 ? -34.08386 5.18720   51.88624  1.000 27.41861 ? 251 TYR A O   1 
ATOM   2036 C  CB  . TYR A 1 254 ? -33.23838 2.76353   50.09197  1.000 26.43243 ? 251 TYR A CB  1 
ATOM   2037 C  CG  . TYR A 1 254 ? -31.77711 2.84408   49.74602  1.000 25.74996 ? 251 TYR A CG  1 
ATOM   2038 C  CD1 . TYR A 1 254 ? -30.92288 1.74555   49.91665  1.000 28.05014 ? 251 TYR A CD1 1 
ATOM   2039 C  CD2 . TYR A 1 254 ? -31.24743 4.00156   49.22951  1.000 25.03422 ? 251 TYR A CD2 1 
ATOM   2040 C  CE1 . TYR A 1 254 ? -29.56595 1.82533   49.57134  1.000 24.31177 ? 251 TYR A CE1 1 
ATOM   2041 C  CE2 . TYR A 1 254 ? -29.91155 4.09793   48.90244  1.000 22.61113 ? 251 TYR A CE2 1 
ATOM   2042 C  CZ  . TYR A 1 254 ? -29.07386 3.01951   49.07353  1.000 28.28272 ? 251 TYR A CZ  1 
ATOM   2043 O  OH  . TYR A 1 254 ? -27.75494 3.16619   48.71656  1.000 31.36540 ? 251 TYR A OH  1 
ATOM   2044 N  N   . GLU A 1 255 ? -32.09430 4.49766   52.67060  1.000 22.90855 ? 252 GLU A N   1 
ATOM   2045 C  CA  . GLU A 1 255 ? -31.72521 5.80939   53.18453  1.000 32.41090 ? 252 GLU A CA  1 
ATOM   2046 C  C   . GLU A 1 255 ? -30.82450 6.52277   52.18227  1.000 28.66179 ? 252 GLU A C   1 
ATOM   2047 O  O   . GLU A 1 255 ? -29.79719 5.97480   51.77076  1.000 26.62955 ? 252 GLU A O   1 
ATOM   2048 C  CB  . GLU A 1 255 ? -31.02406 5.69310   54.53164  1.000 30.17950 ? 252 GLU A CB  1 
ATOM   2049 C  CG  . GLU A 1 255 ? -30.66972 7.04975   55.09285  1.000 41.77385 ? 252 GLU A CG  1 
ATOM   2050 C  CD  . GLU A 1 255 ? -29.91943 6.95377   56.40565  1.000 57.82572 ? 252 GLU A CD  1 
ATOM   2051 O  OE1 . GLU A 1 255 ? -29.77530 5.82266   56.92999  1.000 63.16769 ? 252 GLU A OE1 1 
ATOM   2052 O  OE2 . GLU A 1 255 ? -29.47925 8.01252   56.90994  1.000 65.37738 ? 252 GLU A OE2 1 
ATOM   2053 N  N   . LEU A 1 256 ? -31.22202 7.73034   51.77925  1.000 24.34978 ? 253 LEU A N   1 
ATOM   2054 C  CA  . LEU A 1 256 ? -30.42266 8.57850   50.89733  1.000 26.10792 ? 253 LEU A CA  1 
ATOM   2055 C  C   . LEU A 1 256 ? -29.63011 9.56922   51.73878  1.000 26.65920 ? 253 LEU A C   1 
ATOM   2056 O  O   . LEU A 1 256 ? -30.21018 10.28498  52.55813  1.000 29.43727 ? 253 LEU A O   1 
ATOM   2057 C  CB  . LEU A 1 256 ? -31.32744 9.32564   49.90050  1.000 24.21490 ? 253 LEU A CB  1 
ATOM   2058 C  CG  . LEU A 1 256 ? -31.98317 8.46729   48.80096  1.000 26.12784 ? 253 LEU A CG  1 
ATOM   2059 C  CD1 . LEU A 1 256 ? -32.95993 9.28757   47.94251  1.000 20.29933 ? 253 LEU A CD1 1 
ATOM   2060 C  CD2 . LEU A 1 256 ? -30.94224 7.82695   47.91914  1.000 19.03884 ? 253 LEU A CD2 1 
ATOM   2061 N  N   . LYS A 1 257 ? -28.31252 9.61669   51.54299  1.000 30.11806 ? 254 LYS A N   1 
ATOM   2062 C  CA  . LYS A 1 257 ? -27.43094 10.45650  52.35738  1.000 30.48621 ? 254 LYS A CA  1 
ATOM   2063 C  C   . LYS A 1 257 ? -26.94988 11.63942  51.53268  1.000 28.53857 ? 254 LYS A C   1 
ATOM   2064 O  O   . LYS A 1 257 ? -26.28346 11.46006  50.50822  1.000 24.26723 ? 254 LYS A O   1 
ATOM   2065 C  CB  . LYS A 1 257 ? -26.21981 9.68255   52.88558  1.000 28.95249 ? 254 LYS A CB  1 
ATOM   2066 C  CG  . LYS A 1 257 ? -26.55208 8.51989   53.80658  1.000 42.83676 ? 254 LYS A CG  1 
ATOM   2067 C  CD  . LYS A 1 257 ? -27.22519 9.00192   55.07757  1.000 47.38264 ? 254 LYS A CD  1 
ATOM   2068 C  CE  . LYS A 1 257 ? -26.24959 9.72494   56.00960  1.000 54.22547 ? 254 LYS A CE  1 
ATOM   2069 N  NZ  . LYS A 1 257 ? -26.89966 10.13408  57.30228  1.000 51.57429 ? 254 LYS A NZ  1 
ATOM   2070 N  N   . HIS A 1 258 ? -27.25776 12.83707  52.00652  1.000 31.22071 ? 255 HIS A N   1 
ATOM   2071 C  CA  . HIS A 1 258 ? -26.81404 14.07079  51.37853  1.000 27.65530 ? 255 HIS A CA  1 
ATOM   2072 C  C   . HIS A 1 258 ? -25.34660 14.00452  50.96600  1.000 29.13670 ? 255 HIS A C   1 
ATOM   2073 O  O   . HIS A 1 258 ? -24.48519 13.58728  51.74031  1.000 28.52340 ? 255 HIS A O   1 
ATOM   2074 C  CB  . HIS A 1 258 ? -27.05048 15.22093  52.35477  1.000 32.75717 ? 255 HIS A CB  1 
ATOM   2075 C  CG  . HIS A 1 258 ? -26.55379 16.53045  51.86201  1.000 27.87653 ? 255 HIS A CG  1 
ATOM   2076 N  ND1 . HIS A 1 258 ? -25.58073 17.24726  52.52077  1.000 37.61867 ? 255 HIS A ND1 1 
ATOM   2077 C  CD2 . HIS A 1 258 ? -26.86889 17.24598  50.75796  1.000 32.09416 ? 255 HIS A CD2 1 
ATOM   2078 C  CE1 . HIS A 1 258 ? -25.32841 18.35548  51.85185  1.000 34.05795 ? 255 HIS A CE1 1 
ATOM   2079 N  NE2 . HIS A 1 258 ? -26.09785 18.38111  50.77920  1.000 32.30566 ? 255 HIS A NE2 1 
ATOM   2080 N  N   . GLY A 1 259 ? -25.07034 14.37362  49.71921  1.000 27.63065 ? 256 GLY A N   1 
ATOM   2081 C  CA  . GLY A 1 259 ? -23.70418 14.42036  49.24625  1.000 23.25669 ? 256 GLY A CA  1 
ATOM   2082 C  C   . GLY A 1 259 ? -23.11160 13.10061  48.79715  1.000 25.75392 ? 256 GLY A C   1 
ATOM   2083 O  O   . GLY A 1 259 ? -21.94280 13.07988  48.39921  1.000 28.29616 ? 256 GLY A O   1 
ATOM   2084 N  N   . THR A 1 260 ? -23.86615 12.00189  48.82646  1.000 24.17616 ? 257 THR A N   1 
ATOM   2085 C  CA  . THR A 1 260 ? -23.33995 10.69835  48.42287  1.000 24.95616 ? 257 THR A CA  1 
ATOM   2086 C  C   . THR A 1 260 ? -23.93362 10.18213  47.11853  1.000 25.19663 ? 257 THR A C   1 
ATOM   2087 O  O   . THR A 1 260 ? -23.58769 9.07781   46.68190  1.000 20.01185 ? 257 THR A O   1 
ATOM   2088 C  CB  . THR A 1 260 ? -23.57442 9.65266   49.52603  1.000 25.59095 ? 257 THR A CB  1 
ATOM   2089 O  OG1 . THR A 1 260 ? -24.98753 9.47429   49.73038  1.000 29.68097 ? 257 THR A OG1 1 
ATOM   2090 C  CG2 . THR A 1 260 ? -22.88174 10.06795  50.82790  1.000 27.93627 ? 257 THR A CG2 1 
ATOM   2091 N  N   . PHE A 1 261 ? -24.83047 10.93566  46.49913  1.000 20.86835 ? 258 PHE A N   1 
ATOM   2092 C  CA  . PHE A 1 261 ? -25.43276 10.54599  45.23657  1.000 25.07405 ? 258 PHE A CA  1 
ATOM   2093 C  C   . PHE A 1 261 ? -25.84102 11.83105  44.55007  1.000 20.04348 ? 258 PHE A C   1 
ATOM   2094 O  O   . PHE A 1 261 ? -25.80647 12.90994  45.14996  1.000 23.41405 ? 258 PHE A O   1 
ATOM   2095 C  CB  . PHE A 1 261 ? -26.64160 9.63333   45.43043  1.000 19.29674 ? 258 PHE A CB  1 
ATOM   2096 C  CG  . PHE A 1 261 ? -27.78859 10.32858  46.07904  1.000 21.69048 ? 258 PHE A CG  1 
ATOM   2097 C  CD1 . PHE A 1 261 ? -27.71968 10.68651  47.42308  1.000 21.80397 ? 258 PHE A CD1 1 
ATOM   2098 C  CD2 . PHE A 1 261 ? -28.92566 10.65835  45.35165  1.000 21.20966 ? 258 PHE A CD2 1 
ATOM   2099 C  CE1 . PHE A 1 261 ? -28.77113 11.35990  48.04196  1.000 23.93160 ? 258 PHE A CE1 1 
ATOM   2100 C  CE2 . PHE A 1 261 ? -29.98974 11.33210  45.97022  1.000 20.41867 ? 258 PHE A CE2 1 
ATOM   2101 C  CZ  . PHE A 1 261 ? -29.90671 11.67808  47.31075  1.000 21.48333 ? 258 PHE A CZ  1 
ATOM   2102 N  N   . THR A 1 262 ? -26.23482 11.71118  43.29048  1.000 16.77432 ? 259 THR A N   1 
ATOM   2103 C  CA  . THR A 1 262 ? -26.70586 12.87216  42.53701  1.000 20.75248 ? 259 THR A CA  1 
ATOM   2104 C  C   . THR A 1 262 ? -28.21696 13.07254  42.68039  1.000 19.59195 ? 259 THR A C   1 
ATOM   2105 O  O   . THR A 1 262 ? -28.67909 14.12393  43.13333  1.000 18.15696 ? 259 THR A O   1 
ATOM   2106 C  CB  . THR A 1 262 ? -26.29678 12.70058  41.07356  1.000 23.07651 ? 259 THR A CB  1 
ATOM   2107 O  OG1 . THR A 1 262 ? -24.87361 12.67195  41.01439  1.000 25.77010 ? 259 THR A OG1 1 
ATOM   2108 C  CG2 . THR A 1 262 ? -26.83855 13.82810  40.17516  1.000 22.12908 ? 259 THR A CG2 1 
ATOM   2109 N  N   . CYS A 1 263 ? -28.99588 12.07449  42.30073  1.000 16.53222 ? 260 CYS A N   1 
ATOM   2110 C  CA  . CYS A 1 263 ? -30.43942 12.16846  42.42517  1.000 16.75183 ? 260 CYS A CA  1 
ATOM   2111 C  C   . CYS A 1 263 ? -30.98466 10.75314  42.44391  1.000 19.86732 ? 260 CYS A C   1 
ATOM   2112 O  O   . CYS A 1 263 ? -30.25289 9.78062   42.22059  1.000 18.19611 ? 260 CYS A O   1 
ATOM   2113 C  CB  . CYS A 1 263 ? -31.05710 12.99828  41.28304  1.000 18.09385 ? 260 CYS A CB  1 
ATOM   2114 S  SG  . CYS A 1 263 ? -30.66827 12.39467  39.61667  1.000 20.95311 ? 260 CYS A SG  1 
ATOM   2115 N  N   . ALA A 1 264 ? -32.27564 10.64025  42.71762  1.000 19.80136 ? 261 ALA A N   1 
ATOM   2116 C  CA  . ALA A 1 264 ? -32.83756 9.30588   42.88877  1.000 18.47760 ? 261 ALA A CA  1 
ATOM   2117 C  C   . ALA A 1 264 ? -34.32087 9.33764   42.59956  1.000 19.40023 ? 261 ALA A C   1 
ATOM   2118 O  O   . ALA A 1 264 ? -34.95227 10.39200  42.61096  1.000 17.31452 ? 261 ALA A O   1 
ATOM   2119 C  CB  . ALA A 1 264 ? -32.59980 8.75524   44.29425  1.000 21.01560 ? 261 ALA A CB  1 
ATOM   2120 N  N   . SER A 1 265 ? -34.87475 8.15919   42.36573  1.000 18.17589 ? 262 SER A N   1 
ATOM   2121 C  CA  . SER A 1 265 ? -36.30767 8.04272   42.17734  1.000 21.78486 ? 262 SER A CA  1 
ATOM   2122 C  C   . SER A 1 265 ? -36.89743 7.12047   43.23344  1.000 24.68691 ? 262 SER A C   1 
ATOM   2123 O  O   . SER A 1 265 ? -36.29041 6.11783   43.61665  1.000 19.82146 ? 262 SER A O   1 
ATOM   2124 C  CB  . SER A 1 265 ? -36.63281 7.57031   40.77205  1.000 18.79249 ? 262 SER A CB  1 
ATOM   2125 O  OG  . SER A 1 265 ? -36.24147 8.58741   39.86307  1.000 24.08281 ? 262 SER A OG  1 
ATOM   2126 N  N   . GLU A 1 266 ? -38.07154 7.49815   43.71609  1.000 20.66594 ? 263 GLU A N   1 
ATOM   2127 C  CA  . GLU A 1 266 ? -38.76889 6.80881   44.78687  1.000 18.59450 ? 263 GLU A CA  1 
ATOM   2128 C  C   . GLU A 1 266 ? -40.12353 6.37997   44.25493  1.000 22.25594 ? 263 GLU A C   1 
ATOM   2129 O  O   . GLU A 1 266 ? -40.80572 7.16537   43.58875  1.000 19.70155 ? 263 GLU A O   1 
ATOM   2130 C  CB  . GLU A 1 266 ? -38.93137 7.73665   45.98198  1.000 22.31073 ? 263 GLU A CB  1 
ATOM   2131 C  CG  . GLU A 1 266 ? -39.82135 7.19106   47.07711  1.000 22.34597 ? 263 GLU A CG  1 
ATOM   2132 C  CD  . GLU A 1 266 ? -40.29275 8.27385   48.02493  1.000 31.28273 ? 263 GLU A CD  1 
ATOM   2133 O  OE1 . GLU A 1 266 ? -41.29369 8.95430   47.71075  1.000 30.29737 ? 263 GLU A OE1 1 
ATOM   2134 O  OE2 . GLU A 1 266 ? -39.64740 8.44526   49.07285  1.000 30.14330 ? 263 GLU A OE2 1 
ATOM   2135 N  N   . TYR A 1 267 ? -40.52593 5.14153   44.53366  1.000 21.07753 ? 264 TYR A N   1 
ATOM   2136 C  CA  . TYR A 1 267 ? -41.79480 4.63672   44.01844  1.000 19.70715 ? 264 TYR A CA  1 
ATOM   2137 C  C   . TYR A 1 267 ? -42.63908 4.10835   45.16548  1.000 25.71807 ? 264 TYR A C   1 
ATOM   2138 O  O   . TYR A 1 267 ? -42.23440 3.16701   45.85874  1.000 22.79875 ? 264 TYR A O   1 
ATOM   2139 C  CB  . TYR A 1 267 ? -41.58849 3.54246   42.96048  1.000 22.20633 ? 264 TYR A CB  1 
ATOM   2140 C  CG  . TYR A 1 267 ? -42.90308 3.03511   42.37391  1.000 20.59308 ? 264 TYR A CG  1 
ATOM   2141 C  CD1 . TYR A 1 267 ? -43.57044 3.75871   41.38535  1.000 22.76711 ? 264 TYR A CD1 1 
ATOM   2142 C  CD2 . TYR A 1 267 ? -43.46992 1.84165   42.81823  1.000 25.58087 ? 264 TYR A CD2 1 
ATOM   2143 C  CE1 . TYR A 1 267 ? -44.75251 3.31007   40.85450  1.000 21.97144 ? 264 TYR A CE1 1 
ATOM   2144 C  CE2 . TYR A 1 267 ? -44.65634 1.38627   42.30537  1.000 23.48063 ? 264 TYR A CE2 1 
ATOM   2145 C  CZ  . TYR A 1 267 ? -45.29746 2.11983   41.31891  1.000 26.62651 ? 264 TYR A CZ  1 
ATOM   2146 O  OH  . TYR A 1 267 ? -46.48072 1.65729   40.78536  1.000 25.31960 ? 264 TYR A OH  1 
ATOM   2147 N  N   . THR A 1 268 ? -43.81197 4.70317   45.35396  1.000 23.26098 ? 265 THR A N   1 
ATOM   2148 C  CA  . THR A 1 268 ? -44.75493 4.26199   46.37454  1.000 24.18559 ? 265 THR A CA  1 
ATOM   2149 C  C   . THR A 1 268 ? -45.95917 3.64690   45.68433  1.000 27.60669 ? 265 THR A C   1 
ATOM   2150 O  O   . THR A 1 268 ? -46.63475 4.32080   44.89954  1.000 28.93226 ? 265 THR A O   1 
ATOM   2151 C  CB  . THR A 1 268 ? -45.19452 5.42050   47.26851  1.000 26.11816 ? 265 THR A CB  1 
ATOM   2152 O  OG1 . THR A 1 268 ? -44.03808 6.04756   47.85688  1.000 30.92887 ? 265 THR A OG1 1 
ATOM   2153 C  CG2 . THR A 1 268 ? -46.11348 4.89547   48.36391  1.000 28.25502 ? 265 THR A CG2 1 
ATOM   2154 N  N   . GLY A 1 269 ? -46.23118 2.37738   45.97557  1.000 26.97148 ? 266 GLY A N   1 
ATOM   2155 C  CA  . GLY A 1 269 ? -47.36348 1.72136   45.35377  1.000 26.72282 ? 266 GLY A CA  1 
ATOM   2156 C  C   . GLY A 1 269 ? -47.09401 0.26904   45.02970  1.000 29.21446 ? 266 GLY A C   1 
ATOM   2157 O  O   . GLY A 1 269 ? -46.31969 -0.38442  45.72655  1.000 28.73513 ? 266 GLY A O   1 
ATOM   2158 N  N   . ASN A 1 270 ? -47.70676 -0.24288  43.96761  1.000 26.80675 ? 267 ASN A N   1 
ATOM   2159 C  CA  . ASN A 1 270 ? -47.56931 -1.64559  43.61829  1.000 31.89988 ? 267 ASN A CA  1 
ATOM   2160 C  C   . ASN A 1 270 ? -47.51367 -1.75094  42.09446  1.000 38.74218 ? 267 ASN A C   1 
ATOM   2161 O  O   . ASN A 1 270 ? -47.47433 -0.74149  41.37889  1.000 28.65939 ? 267 ASN A O   1 
ATOM   2162 C  CB  . ASN A 1 270 ? -48.71559 -2.45095  44.25046  1.000 30.93780 ? 267 ASN A CB  1 
ATOM   2163 C  CG  . ASN A 1 270 ? -50.08903 -1.99687  43.76078  1.000 34.84731 ? 267 ASN A CG  1 
ATOM   2164 O  OD1 . ASN A 1 270 ? -50.32357 -1.84576  42.56126  1.000 33.83187 ? 267 ASN A OD1 1 
ATOM   2165 N  ND2 . ASN A 1 270 ? -50.99741 -1.74961  44.70365  1.000 46.54732 ? 267 ASN A ND2 1 
ATOM   2166 N  N   . TYR A 1 271 ? -47.53521 -2.98842  41.59024  1.000 31.16066 ? 268 TYR A N   1 
ATOM   2167 C  CA  . TYR A 1 271 ? -47.36378 -3.21334  40.15918  1.000 35.70323 ? 268 TYR A CA  1 
ATOM   2168 C  C   . TYR A 1 271 ? -48.48920 -2.62689  39.31659  1.000 42.39988 ? 268 TYR A C   1 
ATOM   2169 O  O   . TYR A 1 271 ? -48.31735 -2.48212  38.10046  1.000 38.80378 ? 268 TYR A O   1 
ATOM   2170 C  CB  . TYR A 1 271 ? -47.23621 -4.71541  39.85986  1.000 38.66629 ? 268 TYR A CB  1 
ATOM   2171 C  CG  . TYR A 1 271 ? -48.52368 -5.52369  39.97804  1.000 46.54351 ? 268 TYR A CG  1 
ATOM   2172 C  CD1 . TYR A 1 271 ? -49.41123 -5.33641  41.04648  1.000 37.53140 ? 268 TYR A CD1 1 
ATOM   2173 C  CD2 . TYR A 1 271 ? -48.84221 -6.49009  39.02728  1.000 42.07298 ? 268 TYR A CD2 1 
ATOM   2174 C  CE1 . TYR A 1 271 ? -50.57813 -6.08480  41.15732  1.000 40.68625 ? 268 TYR A CE1 1 
ATOM   2175 C  CE2 . TYR A 1 271 ? -50.01321 -7.24474  39.12816  1.000 42.43824 ? 268 TYR A CE2 1 
ATOM   2176 C  CZ  . TYR A 1 271 ? -50.87530 -7.03635  40.19487  1.000 50.12047 ? 268 TYR A CZ  1 
ATOM   2177 O  OH  . TYR A 1 271 ? -52.03085 -7.78512  40.29973  1.000 51.16284 ? 268 TYR A OH  1 
ATOM   2178 N  N   . GLN A 1 272 ? -49.64615 -2.30631  39.90898  1.000 33.62801 ? 269 GLN A N   1 
ATOM   2179 C  CA  . GLN A 1 272 ? -50.74374 -1.77868  39.10761  1.000 32.83337 ? 269 GLN A CA  1 
ATOM   2180 C  C   . GLN A 1 272 ? -51.01880 -0.30180  39.32330  1.000 32.33634 ? 269 GLN A C   1 
ATOM   2181 O  O   . GLN A 1 272 ? -51.71565 0.29927   38.50057  1.000 44.08225 ? 269 GLN A O   1 
ATOM   2182 C  CB  . GLN A 1 272 ? -52.03468 -2.57146  39.36402  1.000 37.02898 ? 269 GLN A CB  1 
ATOM   2183 C  CG  . GLN A 1 272 ? -52.01483 -3.89724  38.62353  1.000 48.56803 ? 269 GLN A CG  1 
ATOM   2184 C  CD  . GLN A 1 272 ? -53.21723 -4.76688  38.90789  1.000 52.05566 ? 269 GLN A CD  1 
ATOM   2185 O  OE1 . GLN A 1 272 ? -53.72898 -4.80949  40.03100  1.000 50.88559 ? 269 GLN A OE1 1 
ATOM   2186 N  NE2 . GLN A 1 272 ? -53.67919 -5.46630  37.88404  1.000 45.27669 ? 269 GLN A NE2 1 
ATOM   2187 N  N   . CYS A 1 273 ? -50.50501 0.29518   40.39150  1.000 35.15132 ? 270 CYS A N   1 
ATOM   2188 C  CA  . CYS A 1 273 ? -50.58529 1.74679   40.46263  1.000 37.04644 ? 270 CYS A CA  1 
ATOM   2189 C  C   . CYS A 1 273 ? -49.66765 2.23390   41.57190  1.000 33.45842 ? 270 CYS A C   1 
ATOM   2190 O  O   . CYS A 1 273 ? -49.40974 1.52134   42.54642  1.000 29.04178 ? 270 CYS A O   1 
ATOM   2191 C  CB  . CYS A 1 273 ? -52.02410 2.23306   40.68422  1.000 40.36281 ? 270 CYS A CB  1 
ATOM   2192 S  SG  . CYS A 1 273 ? -52.47702 2.45695   42.38736  1.000 61.25419 ? 270 CYS A SG  1 
ATOM   2193 N  N   . GLY A 1 274 ? -49.16846 3.44843   41.39894  1.000 26.40604 ? 271 GLY A N   1 
ATOM   2194 C  CA  . GLY A 1 274 ? -48.16347 3.94368   42.30669  1.000 22.77835 ? 271 GLY A CA  1 
ATOM   2195 C  C   . GLY A 1 274 ? -47.87382 5.39037   42.00264  1.000 26.92834 ? 271 GLY A C   1 
ATOM   2196 O  O   . GLY A 1 274 ? -48.55098 6.03054   41.19037  1.000 27.58390 ? 271 GLY A O   1 
ATOM   2197 N  N   . HIS A 1 275 ? -46.84958 5.89857   42.66058  1.000 21.19414 ? 272 HIS A N   1 
ATOM   2198 C  CA  . HIS A 1 275 ? -46.45631 7.27103   42.42398  1.000 21.14994 ? 272 HIS A CA  1 
ATOM   2199 C  C   . HIS A 1 275 ? -44.95411 7.38591   42.58009  1.000 19.05374 ? 272 HIS A C   1 
ATOM   2200 O  O   . HIS A 1 275 ? -44.39224 6.91734   43.57467  1.000 19.39493 ? 272 HIS A O   1 
ATOM   2201 C  CB  . HIS A 1 275 ? -47.16045 8.20750   43.40469  1.000 21.31842 ? 272 HIS A CB  1 
ATOM   2202 C  CG  . HIS A 1 275 ? -46.94302 9.65885   43.10555  1.000 24.28413 ? 272 HIS A CG  1 
ATOM   2203 N  ND1 . HIS A 1 275 ? -47.65215 10.32962  42.13339  1.000 26.09826 ? 272 HIS A ND1 1 
ATOM   2204 C  CD2 . HIS A 1 275 ? -46.10290 10.56705  43.65355  1.000 20.91813 ? 272 HIS A CD2 1 
ATOM   2205 C  CE1 . HIS A 1 275 ? -47.26105 11.59195  42.09726  1.000 23.54922 ? 272 HIS A CE1 1 
ATOM   2206 N  NE2 . HIS A 1 275 ? -46.31919 11.76120  43.00711  1.000 23.29898 ? 272 HIS A NE2 1 
ATOM   2207 N  N   . TYR A 1 276 ? -44.31291 8.01393   41.60621  1.000 19.00198 ? 273 TYR A N   1 
ATOM   2208 C  CA  . TYR A 1 276 ? -42.89619 8.31136   41.69690  1.000 17.35663 ? 273 TYR A CA  1 
ATOM   2209 C  C   . TYR A 1 276 ? -42.67936 9.71121   42.25669  1.000 18.61519 ? 273 TYR A C   1 
ATOM   2210 O  O   . TYR A 1 276 ? -43.42438 10.64392  41.94030  1.000 21.34287 ? 273 TYR A O   1 
ATOM   2211 C  CB  . TYR A 1 276 ? -42.23801 8.25642   40.32625  1.000 17.64948 ? 273 TYR A CB  1 
ATOM   2212 C  CG  . TYR A 1 276 ? -41.82290 6.89883   39.83688  1.000 17.12688 ? 273 TYR A CG  1 
ATOM   2213 C  CD1 . TYR A 1 276 ? -40.63645 6.30425   40.29512  1.000 19.27710 ? 273 TYR A CD1 1 
ATOM   2214 C  CD2 . TYR A 1 276 ? -42.58253 6.22134   38.88430  1.000 18.63776 ? 273 TYR A CD2 1 
ATOM   2215 C  CE1 . TYR A 1 276 ? -40.23570 5.07687   39.82939  1.000 18.06137 ? 273 TYR A CE1 1 
ATOM   2216 C  CE2 . TYR A 1 276 ? -42.17076 4.98776   38.39421  1.000 15.81708 ? 273 TYR A CE2 1 
ATOM   2217 C  CZ  . TYR A 1 276 ? -40.99823 4.43095   38.87174  1.000 24.36667 ? 273 TYR A CZ  1 
ATOM   2218 O  OH  . TYR A 1 276 ? -40.58040 3.21429   38.39285  1.000 19.88449 ? 273 TYR A OH  1 
ATOM   2219 N  N   . LYS A 1 277 ? -41.61233 9.85952   43.04009  1.000 17.35369 ? 274 LYS A N   1 
ATOM   2220 C  CA  . LYS A 1 277 ? -41.07573 11.16174  43.41637  1.000 18.50698 ? 274 LYS A CA  1 
ATOM   2221 C  C   . LYS A 1 277 ? -39.59098 11.18576  43.07926  1.000 22.24388 ? 274 LYS A C   1 
ATOM   2222 O  O   . LYS A 1 277 ? -38.96300 10.14548  42.87083  1.000 18.38713 ? 274 LYS A O   1 
ATOM   2223 C  CB  . LYS A 1 277 ? -41.27139 11.45625  44.91213  1.000 20.17323 ? 274 LYS A CB  1 
ATOM   2224 C  CG  . LYS A 1 277 ? -42.71595 11.58297  45.36331  1.000 22.83799 ? 274 LYS A CG  1 
ATOM   2225 C  CD  . LYS A 1 277 ? -42.80090 12.08797  46.82311  1.000 20.44559 ? 274 LYS A CD  1 
ATOM   2226 C  CE  . LYS A 1 277 ? -44.24239 12.01512  47.31271  1.000 23.95037 ? 274 LYS A CE  1 
ATOM   2227 N  NZ  . LYS A 1 277 ? -44.31495 12.26245  48.77616  1.000 25.40971 ? 274 LYS A NZ  1 
ATOM   2228 N  N   . HIS A 1 278 ? -39.03226 12.38976  43.05831  1.000 20.98825 ? 275 HIS A N   1 
ATOM   2229 C  CA  . HIS A 1 278 ? -37.63845 12.62083  42.72069  1.000 17.09234 ? 275 HIS A CA  1 
ATOM   2230 C  C   . HIS A 1 278 ? -36.92167 13.21825  43.92652  1.000 19.49226 ? 275 HIS A C   1 
ATOM   2231 O  O   . HIS A 1 278 ? -37.45236 14.11350  44.59732  1.000 19.94762 ? 275 HIS A O   1 
ATOM   2232 C  CB  . HIS A 1 278 ? -37.56095 13.57300  41.52691  1.000 17.28444 ? 275 HIS A CB  1 
ATOM   2233 C  CG  . HIS A 1 278 ? -36.17514 13.86847  41.07244  1.000 18.36800 ? 275 HIS A CG  1 
ATOM   2234 N  ND1 . HIS A 1 278 ? -35.55095 13.14683  40.07762  1.000 19.19778 ? 275 HIS A ND1 1 
ATOM   2235 C  CD2 . HIS A 1 278 ? -35.29276 14.81808  41.45990  1.000 18.60541 ? 275 HIS A CD2 1 
ATOM   2236 C  CE1 . HIS A 1 278 ? -34.33446 13.62831  39.88681  1.000 17.35222 ? 275 HIS A CE1 1 
ATOM   2237 N  NE2 . HIS A 1 278 ? -34.15466 14.64447  40.70923  1.000 20.97386 ? 275 HIS A NE2 1 
ATOM   2238 N  N   . ILE A 1 279 ? -35.72178 12.72931  44.21380  1.000 19.29914 ? 276 ILE A N   1 
ATOM   2239 C  CA  . ILE A 1 279 ? -34.88682 13.30134  45.26687  1.000 18.34861 ? 276 ILE A CA  1 
ATOM   2240 C  C   . ILE A 1 279 ? -33.56402 13.71196  44.63992  1.000 21.24305 ? 276 ILE A C   1 
ATOM   2241 O  O   . ILE A 1 279 ? -32.92047 12.90634  43.96021  1.000 18.71302 ? 276 ILE A O   1 
ATOM   2242 C  CB  . ILE A 1 279 ? -34.67266 12.32660  46.44237  1.000 20.71038 ? 276 ILE A CB  1 
ATOM   2243 C  CG1 . ILE A 1 279 ? -36.01708 11.93328  47.08937  1.000 24.44304 ? 276 ILE A CG1 1 
ATOM   2244 C  CG2 . ILE A 1 279 ? -33.83885 12.99533  47.52163  1.000 22.61367 ? 276 ILE A CG2 1 
ATOM   2245 C  CD1 . ILE A 1 279 ? -36.68288 10.74469  46.47030  1.000 26.24583 ? 276 ILE A CD1 1 
ATOM   2246 N  N   . THR A 1 280 ? -33.17124 14.96758  44.85210  1.000 17.95762 ? 277 THR A N   1 
ATOM   2247 C  CA  . THR A 1 280 ? -31.91855 15.50649  44.34186  1.000 17.64022 ? 277 THR A CA  1 
ATOM   2248 C  C   . THR A 1 280 ? -31.08554 15.98453  45.52594  1.000 22.99635 ? 277 THR A C   1 
ATOM   2249 O  O   . THR A 1 280 ? -31.62169 16.56436  46.47977  1.000 17.72136 ? 277 THR A O   1 
ATOM   2250 C  CB  . THR A 1 280 ? -32.15984 16.65401  43.32845  1.000 21.96396 ? 277 THR A CB  1 
ATOM   2251 O  OG1 . THR A 1 280 ? -30.90631 17.19456  42.89528  1.000 20.42821 ? 277 THR A OG1 1 
ATOM   2252 C  CG2 . THR A 1 280 ? -33.03205 17.78467  43.92638  1.000 22.44424 ? 277 THR A CG2 1 
ATOM   2253 N  N   . SER A 1 281 ? -29.77527 15.71232  45.48356  1.000 19.24446 ? 278 SER A N   1 
ATOM   2254 C  CA  . SER A 1 281 ? -28.87829 16.07609  46.57543  1.000 19.69277 ? 278 SER A CA  1 
ATOM   2255 C  C   . SER A 1 281 ? -28.12345 17.34361  46.16508  1.000 23.61667 ? 278 SER A C   1 
ATOM   2256 O  O   . SER A 1 281 ? -27.21193 17.29455  45.33768  1.000 25.09210 ? 278 SER A O   1 
ATOM   2257 C  CB  . SER A 1 281 ? -27.93774 14.92114  46.89559  1.000 18.17758 ? 278 SER A CB  1 
ATOM   2258 O  OG  . SER A 1 281 ? -27.01383 15.29037  47.90362  1.000 21.01350 ? 278 SER A OG  1 
ATOM   2259 N  N   . LYS A 1 282 ? -28.52304 18.48617  46.72158  1.000 22.98917 ? 279 LYS A N   1 
ATOM   2260 C  CA  . LYS A 1 282 ? -27.81520 19.74107  46.46759  1.000 20.64871 ? 279 LYS A CA  1 
ATOM   2261 C  C   . LYS A 1 282 ? -27.23418 20.28667  47.76422  1.000 26.06483 ? 279 LYS A C   1 
ATOM   2262 O  O   . LYS A 1 282 ? -26.52731 19.55751  48.46108  1.000 24.83417 ? 279 LYS A O   1 
ATOM   2263 C  CB  . LYS A 1 282 ? -28.75123 20.75927  45.80308  1.000 28.44153 ? 279 LYS A CB  1 
ATOM   2264 C  CG  . LYS A 1 282 ? -29.50235 20.18783  44.58690  1.000 23.19430 ? 279 LYS A CG  1 
ATOM   2265 C  CD  . LYS A 1 282 ? -28.54964 19.74503  43.46926  1.000 28.61533 ? 279 LYS A CD  1 
ATOM   2266 C  CE  . LYS A 1 282 ? -28.02882 20.92504  42.65931  1.000 31.77159 ? 279 LYS A CE  1 
ATOM   2267 N  NZ  . LYS A 1 282 ? -27.47450 20.47038  41.33637  1.000 40.88433 ? 279 LYS A NZ  1 
ATOM   2268 N  N   . GLU A 1 283 ? -27.52009 21.55234  48.11321  1.000 22.20560 ? 280 GLU A N   1 
ATOM   2269 C  CA  . GLU A 1 283 ? -27.12281 22.03770  49.43497  1.000 26.08804 ? 280 GLU A CA  1 
ATOM   2270 C  C   . GLU A 1 283 ? -27.87338 21.31882  50.54682  1.000 28.53093 ? 280 GLU A C   1 
ATOM   2271 O  O   . GLU A 1 283 ? -27.38383 21.26681  51.67892  1.000 28.94353 ? 280 GLU A O   1 
ATOM   2272 C  CB  . GLU A 1 283 ? -27.34457 23.55299  49.57017  1.000 24.10138 ? 280 GLU A CB  1 
ATOM   2273 C  CG  . GLU A 1 283 ? -28.81161 23.99221  49.47297  1.000 24.07049 ? 280 GLU A CG  1 
ATOM   2274 C  CD  . GLU A 1 283 ? -29.26471 24.27519  48.03118  1.000 34.14375 ? 280 GLU A CD  1 
ATOM   2275 O  OE1 . GLU A 1 283 ? -28.65319 23.70713  47.09147  1.000 34.67050 ? 280 GLU A OE1 1 
ATOM   2276 O  OE2 . GLU A 1 283 ? -30.22006 25.08142  47.83245  1.000 29.42626 ? 280 GLU A OE2 1 
ATOM   2277 N  N   . THR A 1 284 ? -29.05344 20.77930  50.25788  1.000 22.13647 ? 281 THR A N   1 
ATOM   2278 C  CA  . THR A 1 284 ? -29.70795 19.83684  51.14568  1.000 20.38118 ? 281 THR A CA  1 
ATOM   2279 C  C   . THR A 1 284 ? -30.41535 18.82026  50.25571  1.000 21.09707 ? 281 THR A C   1 
ATOM   2280 O  O   . THR A 1 284 ? -30.18228 18.78156  49.04769  1.000 21.01217 ? 281 THR A O   1 
ATOM   2281 C  CB  . THR A 1 284 ? -30.64767 20.56315  52.11813  1.000 24.03218 ? 281 THR A CB  1 
ATOM   2282 O  OG1 . THR A 1 284 ? -31.21257 19.61836  53.04065  1.000 26.03858 ? 281 THR A OG1 1 
ATOM   2283 C  CG2 . THR A 1 284 ? -31.74834 21.25482  51.35981  1.000 21.66020 ? 281 THR A CG2 1 
ATOM   2284 N  N   . LEU A 1 285 ? -31.28364 17.98715  50.83804  1.000 20.94356 ? 282 LEU A N   1 
ATOM   2285 C  CA  . LEU A 1 285 ? -32.03668 17.00949  50.05543  1.000 16.99068 ? 282 LEU A CA  1 
ATOM   2286 C  C   . LEU A 1 285 ? -33.37599 17.61094  49.67505  1.000 21.86119 ? 282 LEU A C   1 
ATOM   2287 O  O   . LEU A 1 285 ? -34.19691 17.91206  50.54738  1.000 25.24772 ? 282 LEU A O   1 
ATOM   2288 C  CB  . LEU A 1 285 ? -32.24663 15.69944  50.81262  1.000 19.81629 ? 282 LEU A CB  1 
ATOM   2289 C  CG  . LEU A 1 285 ? -30.97619 14.96108  51.22759  1.000 27.34179 ? 282 LEU A CG  1 
ATOM   2290 C  CD1 . LEU A 1 285 ? -31.32527 13.67750  51.98547  1.000 29.26586 ? 282 LEU A CD1 1 
ATOM   2291 C  CD2 . LEU A 1 285 ? -30.07805 14.66176  50.03179  1.000 23.62668 ? 282 LEU A CD2 1 
ATOM   2292 N  N   . TYR A 1 286 ? -33.59354 17.78901  48.37816  1.000 23.08124 ? 283 TYR A N   1 
ATOM   2293 C  CA  . TYR A 1 286 ? -34.85338 18.31599  47.87751  1.000 20.06784 ? 283 TYR A CA  1 
ATOM   2294 C  C   . TYR A 1 286 ? -35.67256 17.17764  47.29356  1.000 21.06842 ? 283 TYR A C   1 
ATOM   2295 O  O   . TYR A 1 286 ? -35.15930 16.38530  46.51322  1.000 22.31121 ? 283 TYR A O   1 
ATOM   2296 C  CB  . TYR A 1 286 ? -34.61624 19.39352  46.81751  1.000 20.99737 ? 283 TYR A CB  1 
ATOM   2297 C  CG  . TYR A 1 286 ? -34.03750 20.65441  47.39857  1.000 22.14860 ? 283 TYR A CG  1 
ATOM   2298 C  CD1 . TYR A 1 286 ? -34.77533 21.42116  48.28878  1.000 22.48624 ? 283 TYR A CD1 1 
ATOM   2299 C  CD2 . TYR A 1 286 ? -32.75950 21.08258  47.05824  1.000 23.49824 ? 283 TYR A CD2 1 
ATOM   2300 C  CE1 . TYR A 1 286 ? -34.25495 22.58269  48.84044  1.000 21.20504 ? 283 TYR A CE1 1 
ATOM   2301 C  CE2 . TYR A 1 286 ? -32.22582 22.24174  47.60060  1.000 22.86684 ? 283 TYR A CE2 1 
ATOM   2302 C  CZ  . TYR A 1 286 ? -32.97666 22.98386  48.49141  1.000 26.94097 ? 283 TYR A CZ  1 
ATOM   2303 O  OH  . TYR A 1 286 ? -32.45523 24.13021  49.02218  1.000 24.74783 ? 283 TYR A OH  1 
ATOM   2304 N  N   . CYS A 1 287 ? -36.93722 17.10043  47.66203  1.000 18.93081 ? 284 CYS A N   1 
ATOM   2305 C  CA  . CYS A 1 287 ? -37.84622 16.12683  47.06083  1.000 22.03418 ? 284 CYS A CA  1 
ATOM   2306 C  C   . CYS A 1 287 ? -38.77328 16.88648  46.12496  1.000 22.45145 ? 284 CYS A C   1 
ATOM   2307 O  O   . CYS A 1 287 ? -39.60953 17.67762  46.58153  1.000 20.12712 ? 284 CYS A O   1 
ATOM   2308 C  CB  . CYS A 1 287 ? -38.63455 15.37777  48.12966  1.000 21.04764 ? 284 CYS A CB  1 
ATOM   2309 S  SG  . CYS A 1 287 ? -39.82870 14.19260  47.47389  1.000 23.62605 ? 284 CYS A SG  1 
ATOM   2310 N  N   . ILE A 1 288 ? -38.61440 16.65906  44.82160  1.000 18.02855 ? 285 ILE A N   1 
ATOM   2311 C  CA  . ILE A 1 288 ? -39.45134 17.28349  43.81055  1.000 19.61828 ? 285 ILE A CA  1 
ATOM   2312 C  C   . ILE A 1 288 ? -40.52216 16.28052  43.40319  1.000 22.29880 ? 285 ILE A C   1 
ATOM   2313 O  O   . ILE A 1 288 ? -40.22434 15.18648  42.90776  1.000 20.68718 ? 285 ILE A O   1 
ATOM   2314 C  CB  . ILE A 1 288 ? -38.62369 17.75149  42.60799  1.000 16.83137 ? 285 ILE A CB  1 
ATOM   2315 C  CG1 . ILE A 1 288 ? -37.48140 18.66543  43.08731  1.000 17.40578 ? 285 ILE A CG1 1 
ATOM   2316 C  CG2 . ILE A 1 288 ? -39.53710 18.43761  41.59371  1.000 18.47223 ? 285 ILE A CG2 1 
ATOM   2317 C  CD1 . ILE A 1 288 ? -36.49857 19.10266  41.96318  1.000 18.41562 ? 285 ILE A CD1 1 
ATOM   2318 N  N   . ASP A 1 289 ? -41.76851 16.63052  43.65021  1.000 18.48016 ? 286 ASP A N   1 
ATOM   2319 C  CA  . ASP A 1 289 ? -42.89951 15.76473  43.34784  1.000 19.30087 ? 286 ASP A CA  1 
ATOM   2320 C  C   . ASP A 1 289 ? -43.78396 16.52919  42.37198  1.000 23.30605 ? 286 ASP A C   1 
ATOM   2321 O  O   . ASP A 1 289 ? -44.76738 17.15183  42.78072  1.000 20.52012 ? 286 ASP A O   1 
ATOM   2322 C  CB  . ASP A 1 289 ? -43.62454 15.40178  44.61116  1.000 20.55977 ? 286 ASP A CB  1 
ATOM   2323 C  CG  . ASP A 1 289 ? -44.79483 14.49418  44.36468  1.000 28.07354 ? 286 ASP A CG  1 
ATOM   2324 O  OD1 . ASP A 1 289 ? -44.95210 14.01339  43.22824  1.000 20.23086 ? 286 ASP A OD1 1 
ATOM   2325 O  OD2 . ASP A 1 289 ? -45.57047 14.26696  45.30957  1.000 30.51804 ? 286 ASP A OD2 1 
ATOM   2326 N  N   . GLY A 1 290 ? -43.40540 16.49758  41.09045  1.000 24.16509 ? 287 GLY A N   1 
ATOM   2327 C  CA  . GLY A 1 290 ? -44.04745 17.29291  40.05974  1.000 19.34836 ? 287 GLY A CA  1 
ATOM   2328 C  C   . GLY A 1 290 ? -43.83212 18.77397  40.30539  1.000 22.28852 ? 287 GLY A C   1 
ATOM   2329 O  O   . GLY A 1 290 ? -42.69860 19.27035  40.20611  1.000 17.02693 ? 287 GLY A O   1 
ATOM   2330 N  N   . ALA A 1 291 ? -44.91570 19.49110  40.64061  1.000 20.08305 ? 288 ALA A N   1 
ATOM   2331 C  CA  . ALA A 1 291 ? -44.84833 20.90903  40.99852  1.000 23.05855 ? 288 ALA A CA  1 
ATOM   2332 C  C   . ALA A 1 291 ? -44.52142 21.14152  42.46844  1.000 22.05007 ? 288 ALA A C   1 
ATOM   2333 O  O   . ALA A 1 291 ? -44.17527 22.27085  42.84372  1.000 19.10688 ? 288 ALA A O   1 
ATOM   2334 C  CB  . ALA A 1 291 ? -46.17108 21.60470  40.66941  1.000 18.77546 ? 288 ALA A CB  1 
ATOM   2335 N  N   . LEU A 1 292 ? -44.58060 20.09694  43.28993  1.000 19.77705 ? 289 LEU A N   1 
ATOM   2336 C  CA  . LEU A 1 292 ? -44.42818 20.20246  44.73277  1.000 21.28276 ? 289 LEU A CA  1 
ATOM   2337 C  C   . LEU A 1 292 ? -42.96625 20.08552  45.10748  1.000 21.40889 ? 289 LEU A C   1 
ATOM   2338 O  O   . LEU A 1 292 ? -42.20791 19.32297  44.49608  1.000 20.90534 ? 289 LEU A O   1 
ATOM   2339 C  CB  . LEU A 1 292 ? -45.20953 19.10256  45.46088  1.000 19.55829 ? 289 LEU A CB  1 
ATOM   2340 C  CG  . LEU A 1 292 ? -46.67526 18.95194  45.04298  1.000 25.40235 ? 289 LEU A CG  1 
ATOM   2341 C  CD1 . LEU A 1 292 ? -47.39070 17.87132  45.85180  1.000 24.63480 ? 289 LEU A CD1 1 
ATOM   2342 C  CD2 . LEU A 1 292 ? -47.37242 20.27641  45.16270  1.000 25.41601 ? 289 LEU A CD2 1 
ATOM   2343 N  N   . LEU A 1 293 ? -42.57830 20.82315  46.14328  1.000 16.23081 ? 290 LEU A N   1 
ATOM   2344 C  CA  . LEU A 1 293 ? -41.19995 20.75784  46.60067  1.000 16.33714 ? 290 LEU A CA  1 
ATOM   2345 C  C   . LEU A 1 293 ? -41.16617 20.73390  48.11846  1.000 19.51013 ? 290 LEU A C   1 
ATOM   2346 O  O   . LEU A 1 293 ? -41.80133 21.56700  48.77024  1.000 18.66414 ? 290 LEU A O   1 
ATOM   2347 C  CB  . LEU A 1 293 ? -40.39788 21.95147  46.06324  1.000 19.08319 ? 290 LEU A CB  1 
ATOM   2348 C  CG  . LEU A 1 293 ? -38.99594 22.15798  46.62925  1.000 24.31922 ? 290 LEU A CG  1 
ATOM   2349 C  CD1 . LEU A 1 293 ? -38.07121 21.00879  46.17741  1.000 16.50629 ? 290 LEU A CD1 1 
ATOM   2350 C  CD2 . LEU A 1 293 ? -38.45630 23.53195  46.24429  1.000 19.14194 ? 290 LEU A CD2 1 
ATOM   2351 N  N   . THR A 1 294 ? -40.43430 19.77374  48.67045  1.000 18.90542 ? 291 THR A N   1 
ATOM   2352 C  CA  . THR A 1 294 ? -40.13137 19.73996  50.09055  1.000 21.01657 ? 291 THR A CA  1 
ATOM   2353 C  C   . THR A 1 294 ? -38.63017 19.51723  50.25174  1.000 24.87119 ? 291 THR A C   1 
ATOM   2354 O  O   . THR A 1 294 ? -37.94151 19.11716  49.30915  1.000 19.96856 ? 291 THR A O   1 
ATOM   2355 C  CB  . THR A 1 294 ? -40.93143 18.63878  50.82026  1.000 21.12159 ? 291 THR A CB  1 
ATOM   2356 O  OG1 . THR A 1 294 ? -40.61143 17.34966  50.26319  1.000 21.68891 ? 291 THR A OG1 1 
ATOM   2357 C  CG2 . THR A 1 294 ? -42.44500 18.88710  50.68479  1.000 18.66642 ? 291 THR A CG2 1 
ATOM   2358 N  N   . LYS A 1 295 ? -38.10979 19.80746  51.44376  1.000 17.73197 ? 292 LYS A N   1 
ATOM   2359 C  CA  . LYS A 1 295 ? -36.70179 19.55857  51.72030  1.000 21.59659 ? 292 LYS A CA  1 
ATOM   2360 C  C   . LYS A 1 295 ? -36.55130 18.81597  53.04150  1.000 23.48841 ? 292 LYS A C   1 
ATOM   2361 O  O   . LYS A 1 295 ? -37.45180 18.80037  53.88395  1.000 24.45472 ? 292 LYS A O   1 
ATOM   2362 C  CB  . LYS A 1 295 ? -35.89782 20.86011  51.76629  1.000 23.26136 ? 292 LYS A CB  1 
ATOM   2363 C  CG  . LYS A 1 295 ? -36.16921 21.67710  53.02101  1.000 26.83997 ? 292 LYS A CG  1 
ATOM   2364 C  CD  . LYS A 1 295 ? -35.27110 22.90671  53.09720  1.000 31.28968 ? 292 LYS A CD  1 
ATOM   2365 C  CE  . LYS A 1 295 ? -35.52021 23.64770  54.39362  1.000 32.15910 ? 292 LYS A CE  1 
ATOM   2366 N  NZ  . LYS A 1 295 ? -34.43633 24.61246  54.73937  1.000 28.36816 ? 292 LYS A NZ  1 
ATOM   2367 N  N   . SER A 1 296 ? -35.38765 18.19802  53.21881  1.000 25.40475 ? 293 SER A N   1 
ATOM   2368 C  CA  . SER A 1 296 ? -35.07973 17.50750  54.45932  1.000 23.42071 ? 293 SER A CA  1 
ATOM   2369 C  C   . SER A 1 296 ? -33.58339 17.24764  54.50458  1.000 26.54805 ? 293 SER A C   1 
ATOM   2370 O  O   . SER A 1 296 ? -32.90216 17.24476  53.47302  1.000 26.35970 ? 293 SER A O   1 
ATOM   2371 C  CB  . SER A 1 296 ? -35.85498 16.19157  54.58874  1.000 28.58559 ? 293 SER A CB  1 
ATOM   2372 O  OG  . SER A 1 296 ? -35.39676 15.25874  53.63866  1.000 30.07257 ? 293 SER A OG  1 
ATOM   2373 N  N   . SER A 1 297 ? -33.07081 17.04346  55.71182  1.000 29.11928 ? 294 SER A N   1 
ATOM   2374 C  CA  . SER A 1 297 ? -31.64600 16.76594  55.79736  1.000 29.92803 ? 294 SER A CA  1 
ATOM   2375 C  C   . SER A 1 297 ? -31.35391 15.28807  55.56968  1.000 34.12825 ? 294 SER A C   1 
ATOM   2376 O  O   . SER A 1 297 ? -30.30157 14.95048  55.02172  1.000 31.59680 ? 294 SER A O   1 
ATOM   2377 C  CB  . SER A 1 297 ? -31.10556 17.23782  57.14078  1.000 32.07596 ? 294 SER A CB  1 
ATOM   2378 O  OG  . SER A 1 297 ? -31.91176 16.72270  58.16564  1.000 38.78534 ? 294 SER A OG  1 
ATOM   2379 N  N   A GLU A 1 298 ? -32.27203 14.41496  55.97546  0.534 31.69528 ? 295 GLU A N   1 
ATOM   2380 N  N   B GLU A 1 298 ? -32.26729 14.41005  55.96959  0.466 31.72184 ? 295 GLU A N   1 
ATOM   2381 C  CA  A GLU A 1 298 ? -32.21872 12.98168  55.73174  0.534 37.28345 ? 295 GLU A CA  1 
ATOM   2382 C  CA  B GLU A 1 298 ? -32.18971 12.98425  55.69625  0.466 37.26141 ? 295 GLU A CA  1 
ATOM   2383 C  C   A GLU A 1 298 ? -33.38581 12.58225  54.83675  0.534 33.05273 ? 295 GLU A C   1 
ATOM   2384 C  C   B GLU A 1 298 ? -33.38119 12.57629  54.84141  0.466 33.05913 ? 295 GLU A C   1 
ATOM   2385 O  O   A GLU A 1 298 ? -34.42028 13.25428  54.80639  0.534 30.84323 ? 295 GLU A O   1 
ATOM   2386 O  O   B GLU A 1 298 ? -34.42262 13.23833  54.84186  0.466 30.86565 ? 295 GLU A O   1 
ATOM   2387 C  CB  A GLU A 1 298 ? -32.28767 12.18778  57.05008  0.534 37.70385 ? 295 GLU A CB  1 
ATOM   2388 C  CB  B GLU A 1 298 ? -32.17776 12.16297  56.99625  0.466 37.75919 ? 295 GLU A CB  1 
ATOM   2389 C  CG  A GLU A 1 298 ? -30.95585 11.98855  57.77148  0.534 41.15782 ? 295 GLU A CG  1 
ATOM   2390 C  CG  B GLU A 1 298 ? -30.97883 12.42548  57.89674  0.466 40.86467 ? 295 GLU A CG  1 
ATOM   2391 C  CD  A GLU A 1 298 ? -30.37431 13.27068  58.34535  0.534 41.61477 ? 295 GLU A CD  1 
ATOM   2392 C  CD  B GLU A 1 298 ? -29.91520 11.35022  57.78609  0.466 43.22263 ? 295 GLU A CD  1 
ATOM   2393 O  OE1 A GLU A 1 298 ? -31.14934 14.10781  58.86877  0.534 41.15841 ? 295 GLU A OE1 1 
ATOM   2394 O  OE1 B GLU A 1 298 ? -30.07453 10.29312  58.43616  0.466 47.23682 ? 295 GLU A OE1 1 
ATOM   2395 O  OE2 A GLU A 1 298 ? -29.13322 13.43636  58.27192  0.534 41.75250 ? 295 GLU A OE2 1 
ATOM   2396 O  OE2 B GLU A 1 298 ? -28.92879 11.55679  57.04288  0.466 43.20987 ? 295 GLU A OE2 1 
ATOM   2397 N  N   . TYR A 1 299 ? -33.23195 11.46974  54.11522  1.000 29.71262 ? 296 TYR A N   1 
ATOM   2398 C  CA  . TYR A 1 299 ? -34.33907 10.94594  53.31753  1.000 29.22548 ? 296 TYR A CA  1 
ATOM   2399 C  C   . TYR A 1 299 ? -34.35439 9.43120   53.37473  1.000 36.22101 ? 296 TYR A C   1 
ATOM   2400 O  O   . TYR A 1 299 ? -33.35253 8.79029   53.05450  1.000 35.35680 ? 296 TYR A O   1 
ATOM   2401 C  CB  . TYR A 1 299 ? -34.28075 11.38941  51.85009  1.000 31.09045 ? 296 TYR A CB  1 
ATOM   2402 C  CG  . TYR A 1 299 ? -35.63017 11.26467  51.17857  1.000 27.33708 ? 296 TYR A CG  1 
ATOM   2403 C  CD1 . TYR A 1 299 ? -36.07698 10.04548  50.67931  1.000 25.63586 ? 296 TYR A CD1 1 
ATOM   2404 C  CD2 . TYR A 1 299 ? -36.48295 12.36641  51.08407  1.000 33.88546 ? 296 TYR A CD2 1 
ATOM   2405 C  CE1 . TYR A 1 299 ? -37.31304 9.92678   50.09108  1.000 27.05137 ? 296 TYR A CE1 1 
ATOM   2406 C  CE2 . TYR A 1 299 ? -37.73251 12.26335  50.49277  1.000 30.36582 ? 296 TYR A CE2 1 
ATOM   2407 C  CZ  . TYR A 1 299 ? -38.14727 11.03786  49.99119  1.000 29.42107 ? 296 TYR A CZ  1 
ATOM   2408 O  OH  . TYR A 1 299 ? -39.40874 10.94401  49.41214  1.000 28.03436 ? 296 TYR A OH  1 
ATOM   2409 N  N   . LYS A 1 300 ? -35.49511 8.86152   53.75488  1.000 28.54240 ? 297 LYS A N   1 
ATOM   2410 C  CA  . LYS A 1 300 ? -35.68083 7.41940   53.70134  1.000 32.74492 ? 297 LYS A CA  1 
ATOM   2411 C  C   . LYS A 1 300 ? -37.00669 7.13255   53.02032  1.000 38.53437 ? 297 LYS A C   1 
ATOM   2412 O  O   . LYS A 1 300 ? -38.01305 7.78355   53.31678  1.000 29.98599 ? 297 LYS A O   1 
ATOM   2413 C  CB  . LYS A 1 300 ? -35.63667 6.78574   55.09244  1.000 32.41341 ? 297 LYS A CB  1 
ATOM   2414 C  CG  . LYS A 1 300 ? -35.91597 5.30129   55.05560  1.000 41.33389 ? 297 LYS A CG  1 
ATOM   2415 C  CD  . LYS A 1 300 ? -35.61563 4.60141   56.37432  1.000 47.03524 ? 297 LYS A CD  1 
ATOM   2416 C  CE  . LYS A 1 300 ? -36.32633 3.24368   56.43144  1.000 44.82136 ? 297 LYS A CE  1 
ATOM   2417 N  NZ  . LYS A 1 300 ? -35.52884 2.21618   57.17134  1.000 55.93443 ? 297 LYS A NZ  1 
ATOM   2418 N  N   . GLY A 1 301 ? -36.99853 6.18656   52.08513  1.000 29.59256 ? 298 GLY A N   1 
ATOM   2419 C  CA  . GLY A 1 301 ? -38.19779 5.84200   51.36757  1.000 24.56941 ? 298 GLY A CA  1 
ATOM   2420 C  C   . GLY A 1 301 ? -37.96305 4.67588   50.43963  1.000 23.81223 ? 298 GLY A C   1 
ATOM   2421 O  O   . GLY A 1 301 ? -36.85465 4.11283   50.36533  1.000 24.45282 ? 298 GLY A O   1 
ATOM   2422 N  N   . PRO A 1 302 ? -39.02071 4.26625   49.73308  1.000 23.22414 ? 299 PRO A N   1 
ATOM   2423 C  CA  . PRO A 1 302 ? -38.93677 3.13834   48.78277  1.000 24.59118 ? 299 PRO A CA  1 
ATOM   2424 C  C   . PRO A 1 302 ? -38.26933 3.55942   47.47359  1.000 28.86735 ? 299 PRO A C   1 
ATOM   2425 O  O   . PRO A 1 302 ? -38.90316 3.88686   46.46774  1.000 25.71047 ? 299 PRO A O   1 
ATOM   2426 C  CB  . PRO A 1 302 ? -40.40518 2.75512   48.58884  1.000 24.08163 ? 299 PRO A CB  1 
ATOM   2427 C  CG  . PRO A 1 302 ? -41.13907 4.04507   48.75574  1.000 25.49157 ? 299 PRO A CG  1 
ATOM   2428 C  CD  . PRO A 1 302 ? -40.39581 4.80747   49.82735  1.000 22.31966 ? 299 PRO A CD  1 
ATOM   2429 N  N   . ILE A 1 303 ? -36.94893 3.54566   47.49936  1.000 23.23516 ? 300 ILE A N   1 
ATOM   2430 C  CA  . ILE A 1 303 ? -36.12356 4.00955   46.39277  1.000 24.24536 ? 300 ILE A CA  1 
ATOM   2431 C  C   . ILE A 1 303 ? -35.97909 2.89815   45.36137  1.000 24.10945 ? 300 ILE A C   1 
ATOM   2432 O  O   . ILE A 1 303 ? -35.81125 1.71914   45.71212  1.000 24.01268 ? 300 ILE A O   1 
ATOM   2433 C  CB  . ILE A 1 303 ? -34.75557 4.45518   46.93200  1.000 22.15741 ? 300 ILE A CB  1 
ATOM   2434 C  CG1 . ILE A 1 303 ? -34.95919 5.52582   47.99888  1.000 20.08863 ? 300 ILE A CG1 1 
ATOM   2435 C  CG2 . ILE A 1 303 ? -33.85623 4.95149   45.80754  1.000 20.32549 ? 300 ILE A CG2 1 
ATOM   2436 C  CD1 . ILE A 1 303 ? -35.87294 6.65236   47.56731  1.000 24.91621 ? 300 ILE A CD1 1 
ATOM   2437 N  N   A THR A 1 304 ? -36.07355 3.26958   44.07792  0.730 20.09843 ? 301 THR A N   1 
ATOM   2438 N  N   B THR A 1 304 ? -36.00774 3.26077   44.08651  0.270 20.21049 ? 301 THR A N   1 
ATOM   2439 C  CA  A THR A 1 304 ? -35.92744 2.34133   42.96066  0.730 23.25285 ? 301 THR A CA  1 
ATOM   2440 C  CA  B THR A 1 304 ? -35.84094 2.26063   43.05251  0.270 23.09204 ? 301 THR A CA  1 
ATOM   2441 C  C   A THR A 1 304 ? -34.68376 2.57882   42.12190  0.730 20.83202 ? 301 THR A C   1 
ATOM   2442 C  C   B THR A 1 304 ? -34.76882 2.60297   42.02474  0.270 20.87681 ? 301 THR A C   1 
ATOM   2443 O  O   A THR A 1 304 ? -34.17134 1.63610   41.52575  0.730 19.16800 ? 301 THR A O   1 
ATOM   2444 O  O   B THR A 1 304 ? -34.42320 1.72975   41.22316  0.270 20.08048 ? 301 THR A O   1 
ATOM   2445 C  CB  A THR A 1 304 ? -37.13775 2.41564   42.01653  0.730 20.53372 ? 301 THR A CB  1 
ATOM   2446 C  CB  B THR A 1 304 ? -37.18633 1.99434   42.35302  0.270 21.38267 ? 301 THR A CB  1 
ATOM   2447 O  OG1 A THR A 1 304 ? -37.29468 3.76288   41.53941  0.730 21.15244 ? 301 THR A OG1 1 
ATOM   2448 O  OG1 B THR A 1 304 ? -37.10190 0.79934   41.57258  0.270 22.62984 ? 301 THR A OG1 1 
ATOM   2449 C  CG2 A THR A 1 304 ? -38.39786 1.97554   42.72332  0.730 22.98999 ? 301 THR A CG2 1 
ATOM   2450 C  CG2 B THR A 1 304 ? -37.59674 3.16154   41.48147  0.270 21.72704 ? 301 THR A CG2 1 
ATOM   2451 N  N   . ASP A 1 305 ? -34.21242 3.81859   42.03869  1.000 18.79211 ? 302 ASP A N   1 
ATOM   2452 C  CA  . ASP A 1 305 ? -33.13825 4.19406   41.12856  1.000 16.90841 ? 302 ASP A CA  1 
ATOM   2453 C  C   . ASP A 1 305 ? -32.32292 5.28404   41.79650  1.000 24.46738 ? 302 ASP A C   1 
ATOM   2454 O  O   . ASP A 1 305 ? -32.89913 6.25896   42.28346  1.000 19.67283 ? 302 ASP A O   1 
ATOM   2455 C  CB  . ASP A 1 305 ? -33.66787 4.74962   39.79834  1.000 21.69227 ? 302 ASP A CB  1 
ATOM   2456 C  CG  . ASP A 1 305 ? -34.63674 3.81567   39.09975  1.000 23.37567 ? 302 ASP A CG  1 
ATOM   2457 O  OD1 . ASP A 1 305 ? -34.18298 2.81253   38.50085  1.000 23.02361 ? 302 ASP A OD1 1 
ATOM   2458 O  OD2 . ASP A 1 305 ? -35.85196 4.08685   39.17096  1.000 20.81602 ? 302 ASP A OD2 1 
ATOM   2459 N  N   . VAL A 1 306 ? -30.99914 5.15251   41.77253  1.000 20.55094 ? 303 VAL A N   1 
ATOM   2460 C  CA  . VAL A 1 306 ? -30.10534 6.18139   42.30129  1.000 23.14130 ? 303 VAL A CA  1 
ATOM   2461 C  C   . VAL A 1 306 ? -29.04119 6.46776   41.25820  1.000 18.14871 ? 303 VAL A C   1 
ATOM   2462 O  O   . VAL A 1 306 ? -28.48566 5.53666   40.67074  1.000 19.19002 ? 303 VAL A O   1 
ATOM   2463 C  CB  . VAL A 1 306 ? -29.44245 5.74857   43.62541  1.000 18.67533 ? 303 VAL A CB  1 
ATOM   2464 C  CG1 . VAL A 1 306 ? -28.54259 6.85700   44.12932  1.000 20.68539 ? 303 VAL A CG1 1 
ATOM   2465 C  CG2 . VAL A 1 306 ? -30.50784 5.33371   44.65215  1.000 18.36851 ? 303 VAL A CG2 1 
ATOM   2466 N  N   . PHE A 1 307 ? -28.74423 7.74814   41.04019  1.000 20.05072 ? 304 PHE A N   1 
ATOM   2467 C  CA  . PHE A 1 307 ? -27.77119 8.16825   40.04292  1.000 16.22579 ? 304 PHE A CA  1 
ATOM   2468 C  C   . PHE A 1 307 ? -26.54723 8.74586   40.73362  1.000 20.90514 ? 304 PHE A C   1 
ATOM   2469 O  O   . PHE A 1 307 ? -26.66821 9.49439   41.71485  1.000 22.68263 ? 304 PHE A O   1 
ATOM   2470 C  CB  . PHE A 1 307 ? -28.37652 9.19547   39.06848  1.000 18.55927 ? 304 PHE A CB  1 
ATOM   2471 C  CG  . PHE A 1 307 ? -29.47533 8.62666   38.20679  1.000 17.77961 ? 304 PHE A CG  1 
ATOM   2472 C  CD1 . PHE A 1 307 ? -30.74963 8.44553   38.72031  1.000 20.22342 ? 304 PHE A CD1 1 
ATOM   2473 C  CD2 . PHE A 1 307 ? -29.21724 8.23362   36.90005  1.000 20.34721 ? 304 PHE A CD2 1 
ATOM   2474 C  CE1 . PHE A 1 307 ? -31.76371 7.89453   37.93806  1.000 17.58341 ? 304 PHE A CE1 1 
ATOM   2475 C  CE2 . PHE A 1 307 ? -30.23970 7.69399   36.09008  1.000 17.51777 ? 304 PHE A CE2 1 
ATOM   2476 C  CZ  . PHE A 1 307 ? -31.50649 7.51523   36.62298  1.000 19.44731 ? 304 PHE A CZ  1 
ATOM   2477 N  N   . TYR A 1 308 ? -25.36668 8.39426   40.22409  1.000 17.23127 ? 305 TYR A N   1 
ATOM   2478 C  CA  . TYR A 1 308 ? -24.11833 8.82834   40.83839  1.000 23.39933 ? 305 TYR A CA  1 
ATOM   2479 C  C   . TYR A 1 308 ? -23.21978 9.45790   39.79354  1.000 21.87178 ? 305 TYR A C   1 
ATOM   2480 O  O   . TYR A 1 308 ? -23.22646 9.06093   38.62844  1.000 20.13283 ? 305 TYR A O   1 
ATOM   2481 C  CB  . TYR A 1 308 ? -23.35842 7.67315   41.50656  1.000 19.69349 ? 305 TYR A CB  1 
ATOM   2482 C  CG  . TYR A 1 308 ? -24.13560 6.89822   42.54343  1.000 20.49787 ? 305 TYR A CG  1 
ATOM   2483 C  CD1 . TYR A 1 308 ? -24.96212 5.84855   42.17814  1.000 20.86458 ? 305 TYR A CD1 1 
ATOM   2484 C  CD2 . TYR A 1 308 ? -23.99985 7.18366   43.89264  1.000 21.94146 ? 305 TYR A CD2 1 
ATOM   2485 C  CE1 . TYR A 1 308 ? -25.66023 5.12892   43.13261  1.000 19.76448 ? 305 TYR A CE1 1 
ATOM   2486 C  CE2 . TYR A 1 308 ? -24.69000 6.47084   44.85898  1.000 26.29957 ? 305 TYR A CE2 1 
ATOM   2487 C  CZ  . TYR A 1 308 ? -25.52017 5.44103   44.46977  1.000 25.97053 ? 305 TYR A CZ  1 
ATOM   2488 O  OH  . TYR A 1 308 ? -26.20714 4.73576   45.42509  1.000 26.42788 ? 305 TYR A OH  1 
ATOM   2489 N  N   . LYS A 1 309 ? -22.44476 10.44673  40.22365  1.000 25.46263 ? 306 LYS A N   1 
ATOM   2490 C  CA  . LYS A 1 309 ? -21.43922 11.03197  39.35581  1.000 25.36145 ? 306 LYS A CA  1 
ATOM   2491 C  C   . LYS A 1 309 ? -20.26134 10.06976  39.24753  1.000 28.93581 ? 306 LYS A C   1 
ATOM   2492 O  O   . LYS A 1 309 ? -19.96542 9.30208   40.16215  1.000 24.47598 ? 306 LYS A O   1 
ATOM   2493 C  CB  . LYS A 1 309 ? -20.99058 12.40388  39.88944  1.000 27.67218 ? 306 LYS A CB  1 
ATOM   2494 C  CG  . LYS A 1 309 ? -20.09237 13.20805  38.94775  1.000 42.99297 ? 306 LYS A CG  1 
ATOM   2495 C  CD  . LYS A 1 309 ? -20.73855 13.54101  37.58203  1.000 44.51210 ? 306 LYS A CD  1 
ATOM   2496 C  CE  . LYS A 1 309 ? -19.66426 13.69358  36.46826  1.000 36.45168 ? 306 LYS A CE  1 
ATOM   2497 N  NZ  . LYS A 1 309 ? -20.14907 14.33851  35.19552  1.000 49.22689 ? 306 LYS A NZ  1 
ATOM   2498 N  N   . GLU A 1 310 ? -19.59747 10.09861  38.10825  1.000 23.05032 ? 307 GLU A N   1 
ATOM   2499 C  CA  . GLU A 1 310 ? -18.44217 9.24175   37.90352  1.000 23.03508 ? 307 GLU A CA  1 
ATOM   2500 C  C   . GLU A 1 310 ? -17.54420 9.91838   36.88083  1.000 25.99350 ? 307 GLU A C   1 
ATOM   2501 O  O   . GLU A 1 310 ? -17.94967 10.86127  36.19576  1.000 25.18629 ? 307 GLU A O   1 
ATOM   2502 C  CB  . GLU A 1 310 ? -18.89690 7.83250   37.44839  1.000 22.74624 ? 307 GLU A CB  1 
ATOM   2503 C  CG  . GLU A 1 310 ? -17.80067 6.80174   37.19116  1.000 21.63206 ? 307 GLU A CG  1 
ATOM   2504 C  CD  . GLU A 1 310 ? -16.90711 6.62660   38.40253  1.000 30.31878 ? 307 GLU A CD  1 
ATOM   2505 O  OE1 . GLU A 1 310 ? -15.96709 7.43784   38.56273  1.000 25.58958 ? 307 GLU A OE1 1 
ATOM   2506 O  OE2 . GLU A 1 310 ? -17.17294 5.70438   39.20960  1.000 20.79572 ? 307 GLU A OE2 1 
ATOM   2507 N  N   . ASN A 1 311 ? -16.29608 9.46134   36.81775  1.000 25.27348 ? 308 ASN A N   1 
ATOM   2508 C  CA  A ASN A 1 311 ? -15.44481 9.77701   35.68073  0.449 25.69586 ? 308 ASN A CA  1 
ATOM   2509 C  CA  B ASN A 1 311 ? -15.42328 9.78769   35.70206  0.551 25.68356 ? 308 ASN A CA  1 
ATOM   2510 C  C   . ASN A 1 311 ? -14.62142 8.54653   35.34785  1.000 28.11070 ? 308 ASN A C   1 
ATOM   2511 O  O   . ASN A 1 311 ? -14.83468 7.92613   34.30252  1.000 25.62193 ? 308 ASN A O   1 
ATOM   2512 C  CB  A ASN A 1 311 ? -14.54057 10.98455  35.95265  0.449 25.58828 ? 308 ASN A CB  1 
ATOM   2513 C  CB  B ASN A 1 311 ? -14.50606 10.98562  36.02449  0.551 25.54212 ? 308 ASN A CB  1 
ATOM   2514 C  CG  A ASN A 1 311 ? -13.87734 11.51149  34.68223  0.449 29.76747 ? 308 ASN A CG  1 
ATOM   2515 C  CG  B ASN A 1 311 ? -13.97358 10.98460  37.46374  0.551 28.75299 ? 308 ASN A CG  1 
ATOM   2516 O  OD1 A ASN A 1 311 ? -13.30038 10.74949  33.90316  0.449 27.40038 ? 308 ASN A OD1 1 
ATOM   2517 O  OD1 B ASN A 1 311 ? -13.55153 9.96056   37.99819  0.551 29.18963 ? 308 ASN A OD1 1 
ATOM   2518 N  ND2 A ASN A 1 311 ? -13.97606 12.82027  34.46065  0.449 34.38622 ? 308 ASN A ND2 1 
ATOM   2519 N  ND2 B ASN A 1 311 ? -13.97587 12.15717  38.08353  0.551 34.43257 ? 308 ASN A ND2 1 
ATOM   2520 N  N   . SER A 1 312 ? -13.70518 8.17906   36.23812  1.000 27.69988 ? 309 SER A N   1 
ATOM   2521 C  CA  . SER A 1 312 ? -12.90997 6.97581   36.07990  1.000 30.52238 ? 309 SER A CA  1 
ATOM   2522 C  C   . SER A 1 312 ? -12.75371 6.32230   37.44048  1.000 29.86678 ? 309 SER A C   1 
ATOM   2523 O  O   . SER A 1 312 ? -12.36226 6.98412   38.40606  1.000 31.99359 ? 309 SER A O   1 
ATOM   2524 C  CB  . SER A 1 312 ? -11.54386 7.29672   35.47678  1.000 31.22942 ? 309 SER A CB  1 
ATOM   2525 O  OG  . SER A 1 312 ? -10.82138 6.09227   35.30383  1.000 38.89928 ? 309 SER A OG  1 
ATOM   2526 N  N   . TYR A 1 313 ? -13.07218 5.03472   37.51891  1.000 31.27335 ? 310 TYR A N   1 
ATOM   2527 C  CA  . TYR A 1 313 ? -12.91015 4.26533   38.74326  1.000 30.85500 ? 310 TYR A CA  1 
ATOM   2528 C  C   . TYR A 1 313 ? -12.15020 2.97566   38.45172  1.000 31.71396 ? 310 TYR A C   1 
ATOM   2529 O  O   . TYR A 1 313 ? -12.41225 2.29922   37.44805  1.000 28.24514 ? 310 TYR A O   1 
ATOM   2530 C  CB  . TYR A 1 313 ? -14.27222 3.93840   39.40049  1.000 30.99675 ? 310 TYR A CB  1 
ATOM   2531 C  CG  . TYR A 1 313 ? -14.16010 2.91644   40.53549  1.000 28.99329 ? 310 TYR A CG  1 
ATOM   2532 C  CD1 . TYR A 1 313 ? -13.79077 3.30636   41.83138  1.000 26.67911 ? 310 TYR A CD1 1 
ATOM   2533 C  CD2 . TYR A 1 313 ? -14.40255 1.56469   40.30006  1.000 25.78024 ? 310 TYR A CD2 1 
ATOM   2534 C  CE1 . TYR A 1 313 ? -13.68238 2.37160   42.86418  1.000 27.13640 ? 310 TYR A CE1 1 
ATOM   2535 C  CE2 . TYR A 1 313 ? -14.29968 0.63098   41.31503  1.000 30.25877 ? 310 TYR A CE2 1 
ATOM   2536 C  CZ  . TYR A 1 313 ? -13.93580 1.02861   42.59298  1.000 31.84955 ? 310 TYR A CZ  1 
ATOM   2537 O  OH  . TYR A 1 313 ? -13.84078 0.06623   43.57893  1.000 29.50230 ? 310 TYR A OH  1 
ATOM   2538 N  N   . THR A 1 314 ? -11.22057 2.62860   39.34843  1.000 33.13329 ? 311 THR A N   1 
ATOM   2539 C  CA  . THR A 1 314 ? -10.49147 1.36654   39.27912  1.000 32.65721 ? 311 THR A CA  1 
ATOM   2540 C  C   . THR A 1 314 ? -10.45741 0.72971   40.66168  1.000 32.31074 ? 311 THR A C   1 
ATOM   2541 O  O   . THR A 1 314 ? -10.09298 1.38714   41.64329  1.000 33.46260 ? 311 THR A O   1 
ATOM   2542 C  CB  . THR A 1 314 ? -9.06831  1.57269   38.76372  1.000 31.59049 ? 311 THR A CB  1 
ATOM   2543 O  OG1 . THR A 1 314 ? -9.11501  2.19722   37.47377  1.000 37.54170 ? 311 THR A OG1 1 
ATOM   2544 C  CG2 . THR A 1 314 ? -8.34392  0.22905   38.66547  1.000 36.16023 ? 311 THR A CG2 1 
ATOM   2545 N  N   . THR A 1 315 ? -10.84216 -0.54133  40.74083  1.000 29.92205 ? 312 THR A N   1 
ATOM   2546 C  CA  . THR A 1 315 ? -10.87993 -1.22560  42.02499  1.000 31.33935 ? 312 THR A CA  1 
ATOM   2547 C  C   . THR A 1 315 ? -9.47336  -1.37883  42.59853  1.000 38.31907 ? 312 THR A C   1 
ATOM   2548 O  O   . THR A 1 315 ? -8.47526  -1.39534  41.86643  1.000 32.01959 ? 312 THR A O   1 
ATOM   2549 C  CB  . THR A 1 315 ? -11.51287 -2.60938  41.88048  1.000 34.41739 ? 312 THR A CB  1 
ATOM   2550 O  OG1 . THR A 1 315 ? -11.75435 -3.15361  43.17418  1.000 32.12305 ? 312 THR A OG1 1 
ATOM   2551 C  CG2 . THR A 1 315 ? -10.58633 -3.55572  41.12368  1.000 39.58847 ? 312 THR A CG2 1 
ATOM   2552 N  N   . THR A 1 316 ? -9.40836  -1.46333  43.93062  1.000 42.19410 ? 313 THR A N   1 
ATOM   2553 C  CA  . THR A 1 316 ? -8.21356  -1.88985  44.65112  1.000 41.71300 ? 313 THR A CA  1 
ATOM   2554 C  C   . THR A 1 316 ? -8.27761  -3.36161  45.05737  1.000 47.16831 ? 313 THR A C   1 
ATOM   2555 O  O   . THR A 1 316 ? -7.30263  -3.88339  45.60614  1.000 48.69003 ? 313 THR A O   1 
ATOM   2556 C  CB  . THR A 1 316 ? -7.99726  -1.02492  45.90576  1.000 35.93357 ? 313 THR A CB  1 
ATOM   2557 O  OG1 . THR A 1 316 ? -9.04713  -1.27625  46.84032  1.000 44.11171 ? 313 THR A OG1 1 
ATOM   2558 C  CG2 . THR A 1 316 ? -7.99089  0.47586   45.57637  1.000 33.03893 ? 313 THR A CG2 1 
ATOM   2559 N  N   . ILE A 1 317 ? -9.39898  -4.03216  44.80681  1.000 40.73176 ? 314 ILE A N   1 
ATOM   2560 C  CA  . ILE A 1 317 ? -9.55203  -5.45524  45.06691  1.000 45.45900 ? 314 ILE A CA  1 
ATOM   2561 C  C   . ILE A 1 317 ? -8.56418  -6.27649  44.23849  1.000 44.57744 ? 314 ILE A C   1 
ATOM   2562 O  O   . ILE A 1 317 ? -8.55463  -6.19578  43.00360  1.000 40.08712 ? 314 ILE A O   1 
ATOM   2563 C  CB  . ILE A 1 317 ? -10.99929 -5.89505  44.78652  1.000 41.82289 ? 314 ILE A CB  1 
ATOM   2564 C  CG1 . ILE A 1 317 ? -11.93320 -5.35156  45.88338  1.000 41.49486 ? 314 ILE A CG1 1 
ATOM   2565 C  CG2 . ILE A 1 317 ? -11.07302 -7.40488  44.63420  1.000 35.15572 ? 314 ILE A CG2 1 
ATOM   2566 C  CD1 . ILE A 1 317 ? -13.41396 -5.67790  45.68962  1.000 36.25500 ? 314 ILE A CD1 1 
HETATM 2567 ZN ZN  . ZN  B 2 .   ? -20.12190 -21.74888 40.77757  1.000 36.77804 ? 401 ZN  A ZN  1 
HETATM 2568 P  P   . PO4 C 3 .   ? -61.35860 28.95369  13.07980  1.000 55.17301 ? 402 PO4 A P   1 
HETATM 2569 O  O1  . PO4 C 3 .   ? -60.65281 28.16542  12.00608  1.000 48.38961 ? 402 PO4 A O1  1 
HETATM 2570 O  O2  . PO4 C 3 .   ? -60.46816 29.01392  14.30073  1.000 61.77702 ? 402 PO4 A O2  1 
HETATM 2571 O  O3  . PO4 C 3 .   ? -61.61800 30.35467  12.58176  1.000 55.86052 ? 402 PO4 A O3  1 
HETATM 2572 O  O4  . PO4 C 3 .   ? -62.67187 28.27008  13.38427  1.000 52.88627 ? 402 PO4 A O4  1 
HETATM 2573 P  P   . PO4 D 3 .   ? -29.14175 6.48676   17.84490  1.000 47.23244 ? 403 PO4 A P   1 
HETATM 2574 O  O1  . PO4 D 3 .   ? -30.45498 7.25521   17.92853  1.000 28.80522 ? 403 PO4 A O1  1 
HETATM 2575 O  O2  . PO4 D 3 .   ? -29.47606 5.03316   17.59926  1.000 47.55758 ? 403 PO4 A O2  1 
HETATM 2576 O  O3  . PO4 D 3 .   ? -28.32459 7.00340   16.67104  1.000 46.86896 ? 403 PO4 A O3  1 
HETATM 2577 O  O4  . PO4 D 3 .   ? -28.32168 6.59580   19.13318  1.000 34.31522 ? 403 PO4 A O4  1 
HETATM 2578 C  C1  . GOL E 4 .   ? -56.76773 10.71431  22.69211  1.000 44.74010 ? 404 GOL A C1  1 
HETATM 2579 O  O1  . GOL E 4 .   ? -56.48664 10.34489  24.01087  1.000 48.33041 ? 404 GOL A O1  1 
HETATM 2580 C  C2  . GOL E 4 .   ? -55.41066 11.06483  22.04340  1.000 36.77873 ? 404 GOL A C2  1 
HETATM 2581 O  O2  . GOL E 4 .   ? -55.22719 10.42054  20.80957  1.000 52.18507 ? 404 GOL A O2  1 
HETATM 2582 C  C3  . GOL E 4 .   ? -55.43979 12.57443  21.85961  1.000 42.34817 ? 404 GOL A C3  1 
HETATM 2583 O  O3  . GOL E 4 .   ? -54.11234 12.95266  21.73829  1.000 28.92948 ? 404 GOL A O3  1 
HETATM 2584 C  C1  . GOL F 4 .   ? -38.47894 11.13335  54.37788  1.000 41.46166 ? 405 GOL A C1  1 
HETATM 2585 O  O1  . GOL F 4 .   ? -37.51943 10.37335  55.08592  1.000 37.86859 ? 405 GOL A O1  1 
HETATM 2586 C  C2  . GOL F 4 .   ? -37.99821 12.60892  54.54059  1.000 42.91563 ? 405 GOL A C2  1 
HETATM 2587 O  O2  . GOL F 4 .   ? -38.78279 13.49973  53.82566  1.000 57.79507 ? 405 GOL A O2  1 
HETATM 2588 C  C3  . GOL F 4 .   ? -38.02299 12.88130  56.08293  1.000 50.29457 ? 405 GOL A C3  1 
HETATM 2589 O  O3  . GOL F 4 .   ? -36.69071 12.80287  56.56369  1.000 55.67398 ? 405 GOL A O3  1 
HETATM 2590 C  C1  . GOL G 4 .   ? -47.53917 15.39745  2.29854   1.000 36.98783 ? 406 GOL A C1  1 
HETATM 2591 O  O1  . GOL G 4 .   ? -46.14968 15.56791  2.08965   1.000 46.23470 ? 406 GOL A O1  1 
HETATM 2592 C  C2  . GOL G 4 .   ? -47.95056 14.01840  1.77583   1.000 41.33340 ? 406 GOL A C2  1 
HETATM 2593 O  O2  . GOL G 4 .   ? -48.84813 13.40777  2.64254   1.000 45.93566 ? 406 GOL A O2  1 
HETATM 2594 C  C3  . GOL G 4 .   ? -48.58083 14.31087  0.39365   1.000 44.44279 ? 406 GOL A C3  1 
HETATM 2595 O  O3  . GOL G 4 .   ? -49.57282 13.35384  0.21904   1.000 50.36057 ? 406 GOL A O3  1 
HETATM 2596 C  C1  . GOL H 4 .   ? -15.01560 -11.22292 45.54798  1.000 46.81447 ? 407 GOL A C1  1 
HETATM 2597 O  O1  . GOL H 4 .   ? -14.17198 -12.28638 45.85809  1.000 64.34626 ? 407 GOL A O1  1 
HETATM 2598 C  C2  . GOL H 4 .   ? -14.86572 -10.21425 46.70073  1.000 62.27986 ? 407 GOL A C2  1 
HETATM 2599 O  O2  . GOL H 4 .   ? -15.58304 -9.02544  46.48070  1.000 57.10876 ? 407 GOL A O2  1 
HETATM 2600 C  C3  . GOL H 4 .   ? -13.33237 -10.00192 46.82425  1.000 55.00346 ? 407 GOL A C3  1 
HETATM 2601 O  O3  . GOL H 4 .   ? -13.11919 -9.44935  48.08945  1.000 62.29334 ? 407 GOL A O3  1 
HETATM 2602 C  C1  . GOL I 4 .   ? -43.60862 0.42033   38.65909  1.000 38.50384 ? 408 GOL A C1  1 
HETATM 2603 O  O1  . GOL I 4 .   ? -44.50415 -0.64856  38.53556  1.000 39.99659 ? 408 GOL A O1  1 
HETATM 2604 C  C2  . GOL I 4 .   ? -42.30541 -0.26013  38.99030  1.000 40.92976 ? 408 GOL A C2  1 
HETATM 2605 O  O2  . GOL I 4 .   ? -41.63202 -0.59966  37.82244  1.000 37.30556 ? 408 GOL A O2  1 
HETATM 2606 C  C3  . GOL I 4 .   ? -41.55387 0.71011   39.95579  1.000 34.13989 ? 408 GOL A C3  1 
HETATM 2607 O  O3  . GOL I 4 .   ? -40.27029 0.18796   40.23555  1.000 36.98814 ? 408 GOL A O3  1 
HETATM 2608 O  O   . HOH J 5 .   ? -68.58870 26.06949  -9.90814  1.000 42.63944 ? 501 HOH A O   1 
HETATM 2609 O  O   . HOH J 5 .   ? -27.76990 -21.20492 39.63032  1.000 46.15049 ? 502 HOH A O   1 
HETATM 2610 O  O   . HOH J 5 .   ? -18.30742 -11.79352 34.65610  1.000 34.01599 ? 503 HOH A O   1 
HETATM 2611 O  O   . HOH J 5 .   ? -14.44694 -2.25677  43.30401  1.000 29.26847 ? 504 HOH A O   1 
HETATM 2612 O  O   . HOH J 5 .   ? -22.55281 6.96151   47.27325  1.000 39.18062 ? 505 HOH A O   1 
HETATM 2613 O  O   . HOH J 5 .   ? -40.29946 -1.44948  26.73094  1.000 31.26081 ? 506 HOH A O   1 
HETATM 2614 O  O   . HOH J 5 .   ? -40.82206 26.28832  32.86737  1.000 30.64591 ? 507 HOH A O   1 
HETATM 2615 O  O   . HOH J 5 .   ? -18.72546 4.64185   45.62264  1.000 32.84880 ? 508 HOH A O   1 
HETATM 2616 O  O   . HOH J 5 .   ? -29.41765 20.72379  39.85767  1.000 34.49668 ? 509 HOH A O   1 
HETATM 2617 O  O   . HOH J 5 .   ? -47.58768 24.35686  29.39006  1.000 40.76048 ? 510 HOH A O   1 
HETATM 2618 O  O   . HOH J 5 .   ? -30.58520 10.18392  54.99666  1.000 42.86730 ? 511 HOH A O   1 
HETATM 2619 O  O   . HOH J 5 .   ? -49.50385 25.59757  29.57618  1.000 48.33816 ? 512 HOH A O   1 
HETATM 2620 O  O   . HOH J 5 .   ? -34.57684 -0.66557  45.98178  1.000 33.18207 ? 513 HOH A O   1 
HETATM 2621 O  O   . HOH J 5 .   ? -29.85205 12.04547  11.89049  1.000 24.60527 ? 514 HOH A O   1 
HETATM 2622 O  O   . HOH J 5 .   ? -66.198   32.666    -9.427    1.000 31.55298 ? 515 HOH A O   1 
HETATM 2623 O  O   . HOH J 5 .   ? -35.31746 27.84364  36.44708  1.000 34.34810 ? 516 HOH A O   1 
HETATM 2624 O  O   . HOH J 5 .   ? -48.89078 1.64401   24.82376  1.000 30.33615 ? 517 HOH A O   1 
HETATM 2625 O  O   . HOH J 5 .   ? -46.25157 0.66775   37.23101  1.000 39.71159 ? 518 HOH A O   1 
HETATM 2626 O  O   . HOH J 5 .   ? -42.66348 12.45822  40.31002  1.000 32.23033 ? 519 HOH A O   1 
HETATM 2627 O  O   . HOH J 5 .   ? -55.92811 16.83739  24.83878  1.000 41.53213 ? 520 HOH A O   1 
HETATM 2628 O  O   . HOH J 5 .   ? -41.01743 17.34357  15.06591  1.000 27.53212 ? 521 HOH A O   1 
HETATM 2629 O  O   . HOH J 5 .   ? -38.65329 20.16085  14.88662  1.000 25.79621 ? 522 HOH A O   1 
HETATM 2630 O  O   . HOH J 5 .   ? -26.93259 13.29528  15.76807  1.000 34.69719 ? 523 HOH A O   1 
HETATM 2631 O  O   . HOH J 5 .   ? -41.73190 2.77120   8.44355   1.000 27.39075 ? 524 HOH A O   1 
HETATM 2632 O  O   . HOH J 5 .   ? -48.12252 14.05179  45.03946  1.000 31.88600 ? 525 HOH A O   1 
HETATM 2633 O  O   . HOH J 5 .   ? -51.73377 8.04634   12.66772  1.000 33.21779 ? 526 HOH A O   1 
HETATM 2634 O  O   . HOH J 5 .   ? -14.31292 8.35174   40.31465  1.000 40.24453 ? 527 HOH A O   1 
HETATM 2635 O  O   . HOH J 5 .   ? -63.887   23.863    4.512     1.000 27.72137 ? 528 HOH A O   1 
HETATM 2636 O  O   . HOH J 5 .   ? -41.50301 3.86713   19.00461  1.000 35.98898 ? 529 HOH A O   1 
HETATM 2637 O  O   . HOH J 5 .   ? -35.99314 0.42822   39.26502  1.000 22.91678 ? 530 HOH A O   1 
HETATM 2638 O  O   . HOH J 5 .   ? -25.942   7.351     15.719    1.000 39.56396 ? 531 HOH A O   1 
HETATM 2639 O  O   . HOH J 5 .   ? -23.58317 -2.77045  24.88164  1.000 26.48077 ? 532 HOH A O   1 
HETATM 2640 O  O   . HOH J 5 .   ? -49.14867 18.59172  14.38796  1.000 33.89485 ? 533 HOH A O   1 
HETATM 2641 O  O   . HOH J 5 .   ? -49.12925 -3.88308  36.06689  1.000 37.07429 ? 534 HOH A O   1 
HETATM 2642 O  O   . HOH J 5 .   ? -10.14714 -7.36191  40.64245  1.000 36.73588 ? 535 HOH A O   1 
HETATM 2643 O  O   . HOH J 5 .   ? -47.56321 7.29292   30.31538  1.000 25.49617 ? 536 HOH A O   1 
HETATM 2644 O  O   . HOH J 5 .   ? -42.846   23.984    44.295    1.000 21.89273 ? 537 HOH A O   1 
HETATM 2645 O  O   . HOH J 5 .   ? -22.286   4.242     17.935    1.000 28.78121 ? 538 HOH A O   1 
HETATM 2646 O  O   . HOH J 5 .   ? -18.33161 5.75537   18.73710  1.000 37.70353 ? 539 HOH A O   1 
HETATM 2647 O  O   . HOH J 5 .   ? -56.48719 27.52125  12.67642  1.000 34.97731 ? 540 HOH A O   1 
HETATM 2648 O  O   . HOH J 5 .   ? -47.47913 0.34379   31.00266  1.000 41.92723 ? 541 HOH A O   1 
HETATM 2649 O  O   . HOH J 5 .   ? -32.06081 23.50040  54.83997  1.000 42.20330 ? 542 HOH A O   1 
HETATM 2650 O  O   . HOH J 5 .   ? -43.00103 9.67454   49.57737  1.000 33.12650 ? 543 HOH A O   1 
HETATM 2651 O  O   . HOH J 5 .   ? -23.74875 11.41004  26.18001  1.000 25.38778 ? 544 HOH A O   1 
HETATM 2652 O  O   . HOH J 5 .   ? -23.82099 -7.69776  34.97662  1.000 31.20132 ? 545 HOH A O   1 
HETATM 2653 O  O   . HOH J 5 .   ? -54.88115 10.12345  31.67138  1.000 36.75960 ? 546 HOH A O   1 
HETATM 2654 O  O   . HOH J 5 .   ? -43.24406 0.86888   46.65826  1.000 32.92736 ? 547 HOH A O   1 
HETATM 2655 O  O   . HOH J 5 .   ? -40.11708 17.05213  17.56795  1.000 33.49750 ? 548 HOH A O   1 
HETATM 2656 O  O   . HOH J 5 .   ? -46.39754 27.09056  8.46891   1.000 23.87205 ? 549 HOH A O   1 
HETATM 2657 O  O   . HOH J 5 .   ? -32.37003 25.15434  51.45842  1.000 27.71082 ? 550 HOH A O   1 
HETATM 2658 O  O   . HOH J 5 .   ? -40.56932 17.22060  6.91989   1.000 21.18544 ? 551 HOH A O   1 
HETATM 2659 O  O   . HOH J 5 .   ? -9.43993  4.96477   37.25799  1.000 36.46702 ? 552 HOH A O   1 
HETATM 2660 O  O   . HOH J 5 .   ? -26.67176 5.46904   47.97701  1.000 31.22609 ? 553 HOH A O   1 
HETATM 2661 O  O   . HOH J 5 .   ? -19.12910 -18.51747 46.06084  1.000 44.20384 ? 554 HOH A O   1 
HETATM 2662 O  O   . HOH J 5 .   ? -22.57770 11.28830  28.52194  1.000 27.30103 ? 555 HOH A O   1 
HETATM 2663 O  O   . HOH J 5 .   ? -53.30419 18.16882  36.40896  1.000 32.70020 ? 556 HOH A O   1 
HETATM 2664 O  O   . HOH J 5 .   ? -39.092   25.599    8.651     1.000 20.78694 ? 557 HOH A O   1 
HETATM 2665 O  O   . HOH J 5 .   ? -10.42437 2.81411   43.86730  1.000 36.07660 ? 558 HOH A O   1 
HETATM 2666 O  O   . HOH J 5 .   ? -23.96391 4.55027   23.02078  1.000 33.15990 ? 559 HOH A O   1 
HETATM 2667 O  O   . HOH J 5 .   ? -54.36366 13.95863  18.71979  1.000 31.85713 ? 560 HOH A O   1 
HETATM 2668 O  O   . HOH J 5 .   ? -48.54575 10.15203  30.93569  1.000 23.09930 ? 561 HOH A O   1 
HETATM 2669 O  O   . HOH J 5 .   ? -32.87739 20.57659  54.89506  1.000 28.79263 ? 562 HOH A O   1 
HETATM 2670 O  O   . HOH J 5 .   ? -35.23320 15.46600  9.04428   1.000 19.99140 ? 563 HOH A O   1 
HETATM 2671 O  O   . HOH J 5 .   ? -42.50299 5.44495   0.48463   1.000 42.63506 ? 564 HOH A O   1 
HETATM 2672 O  O   . HOH J 5 .   ? -32.16539 22.55660  33.07673  1.000 34.35869 ? 565 HOH A O   1 
HETATM 2673 O  O   . HOH J 5 .   ? -46.666   0.120     26.283    1.000 39.18069 ? 566 HOH A O   1 
HETATM 2674 O  O   . HOH J 5 .   ? -35.49290 16.35124  2.09275   1.000 32.98579 ? 567 HOH A O   1 
HETATM 2675 O  O   . HOH J 5 .   ? -30.07594 19.38790  23.39085  1.000 27.75260 ? 568 HOH A O   1 
HETATM 2676 O  O   . HOH J 5 .   ? -23.93239 -3.27599  34.45769  1.000 28.26633 ? 569 HOH A O   1 
HETATM 2677 O  O   . HOH J 5 .   ? -33.94348 9.98379   39.63828  1.000 19.07405 ? 570 HOH A O   1 
HETATM 2678 O  O   . HOH J 5 .   ? -61.55320 11.57601  6.22017   1.000 37.71332 ? 571 HOH A O   1 
HETATM 2679 O  O   . HOH J 5 .   ? -26.53641 16.47547  42.87262  1.000 28.20323 ? 572 HOH A O   1 
HETATM 2680 O  O   . HOH J 5 .   ? -66.12717 29.64463  -4.02067  1.000 32.10618 ? 573 HOH A O   1 
HETATM 2681 O  O   . HOH J 5 .   ? -43.17303 8.03101   46.01909  1.000 31.98980 ? 574 HOH A O   1 
HETATM 2682 O  O   . HOH J 5 .   ? -73.17140 24.78755  -9.45387  1.000 35.31680 ? 575 HOH A O   1 
HETATM 2683 O  O   . HOH J 5 .   ? -24.07570 14.90174  45.69497  1.000 36.69501 ? 576 HOH A O   1 
HETATM 2684 O  O   . HOH J 5 .   ? -20.566   -25.611   43.813    1.000 33.12404 ? 577 HOH A O   1 
HETATM 2685 O  O   . HOH J 5 .   ? -49.44182 19.27989  34.07502  1.000 22.73095 ? 578 HOH A O   1 
HETATM 2686 O  O   . HOH J 5 .   ? -74.38498 22.86679  -11.13113 1.000 46.54093 ? 579 HOH A O   1 
HETATM 2687 O  O   . HOH J 5 .   ? -50.44011 10.97234  6.53167   1.000 21.30899 ? 580 HOH A O   1 
HETATM 2688 O  O   . HOH J 5 .   ? -54.26309 30.99988  14.04904  1.000 45.16630 ? 581 HOH A O   1 
HETATM 2689 O  O   . HOH J 5 .   ? -25.19396 17.27104  47.61408  1.000 30.03977 ? 582 HOH A O   1 
HETATM 2690 O  O   . HOH J 5 .   ? -28.18122 16.31557  30.35214  1.000 30.73668 ? 583 HOH A O   1 
HETATM 2691 O  O   . HOH J 5 .   ? -16.41368 6.34202   41.83608  1.000 30.32931 ? 584 HOH A O   1 
HETATM 2692 O  O   . HOH J 5 .   ? -44.78749 19.55872  -2.06802  1.000 29.13509 ? 585 HOH A O   1 
HETATM 2693 O  O   . HOH J 5 .   ? -36.27603 -2.34250  27.11428  1.000 40.32166 ? 586 HOH A O   1 
HETATM 2694 O  O   . HOH J 5 .   ? -30.14333 19.02120  16.35208  1.000 30.38035 ? 587 HOH A O   1 
HETATM 2695 O  O   . HOH J 5 .   ? -45.49386 22.12294  20.81556  1.000 45.48583 ? 588 HOH A O   1 
HETATM 2696 O  O   . HOH J 5 .   ? -49.02818 8.09967   22.02782  1.000 20.57012 ? 589 HOH A O   1 
HETATM 2697 O  O   . HOH J 5 .   ? -48.54939 20.97638  13.14669  1.000 18.30186 ? 590 HOH A O   1 
HETATM 2698 O  O   . HOH J 5 .   ? -64.061   21.754    11.585    1.000 41.92614 ? 591 HOH A O   1 
HETATM 2699 O  O   . HOH J 5 .   ? -48.33578 9.34659   38.43384  1.000 36.13910 ? 592 HOH A O   1 
HETATM 2700 O  O   . HOH J 5 .   ? -20.77274 -9.54659  48.70873  1.000 42.85674 ? 593 HOH A O   1 
HETATM 2701 O  O   . HOH J 5 .   ? -54.48745 22.34103  16.68871  1.000 31.30515 ? 594 HOH A O   1 
HETATM 2702 O  O   . HOH J 5 .   ? -31.83033 24.74545  34.60917  1.000 43.45821 ? 595 HOH A O   1 
HETATM 2703 O  O   . HOH J 5 .   ? -42.62838 22.70958  -1.27992  1.000 22.86196 ? 596 HOH A O   1 
HETATM 2704 O  O   . HOH J 5 .   ? -54.23473 15.66914  29.12932  1.000 26.62004 ? 597 HOH A O   1 
HETATM 2705 O  O   . HOH J 5 .   ? -42.080   26.315    40.976    1.000 23.72321 ? 598 HOH A O   1 
HETATM 2706 O  O   . HOH J 5 .   ? -27.58048 17.28615  26.18565  1.000 31.03540 ? 599 HOH A O   1 
HETATM 2707 O  O   . HOH J 5 .   ? -65.72378 17.80272  -3.37343  1.000 38.27705 ? 600 HOH A O   1 
HETATM 2708 O  O   . HOH J 5 .   ? -39.79223 7.44735   10.51529  1.000 26.85019 ? 601 HOH A O   1 
HETATM 2709 O  O   . HOH J 5 .   ? -43.80634 24.83108  10.85544  1.000 25.00374 ? 602 HOH A O   1 
HETATM 2710 O  O   . HOH J 5 .   ? -27.69343 -7.96838  42.13559  1.000 30.12949 ? 603 HOH A O   1 
HETATM 2711 O  O   . HOH J 5 .   ? -64.93069 25.06194  -9.28071  1.000 40.28197 ? 604 HOH A O   1 
HETATM 2712 O  O   . HOH J 5 .   ? -34.41291 24.60411  33.80781  1.000 33.40472 ? 605 HOH A O   1 
HETATM 2713 O  O   . HOH J 5 .   ? -28.39730 13.01519  54.66145  1.000 32.23385 ? 606 HOH A O   1 
HETATM 2714 O  O   . HOH J 5 .   ? -39.54220 20.15812  24.41247  1.000 22.48189 ? 607 HOH A O   1 
HETATM 2715 O  O   . HOH J 5 .   ? -65.069   26.075    3.116     1.000 29.88096 ? 608 HOH A O   1 
HETATM 2716 O  O   . HOH J 5 .   ? -37.80869 17.99745  18.39589  1.000 21.17691 ? 609 HOH A O   1 
HETATM 2717 O  O   . HOH J 5 .   ? -42.20186 6.37256   11.00637  1.000 27.50527 ? 610 HOH A O   1 
HETATM 2718 O  O   . HOH J 5 .   ? -38.00271 -1.26491  37.98011  1.000 33.02514 ? 611 HOH A O   1 
HETATM 2719 O  O   . HOH J 5 .   ? -63.98042 23.07723  -2.75507  1.000 32.31990 ? 612 HOH A O   1 
HETATM 2720 O  O   . HOH J 5 .   ? -32.61738 -1.10296  50.87401  1.000 36.03254 ? 613 HOH A O   1 
HETATM 2721 O  O   . HOH J 5 .   ? -44.67348 4.20548   0.86817   1.000 42.78401 ? 614 HOH A O   1 
HETATM 2722 O  O   . HOH J 5 .   ? -50.48072 9.31704   24.23175  1.000 26.52089 ? 615 HOH A O   1 
HETATM 2723 O  O   . HOH J 5 .   ? -38.67086 15.99117  51.68247  1.000 30.70681 ? 616 HOH A O   1 
HETATM 2724 O  O   . HOH J 5 .   ? -38.93982 24.29307  13.48104  1.000 35.49092 ? 617 HOH A O   1 
HETATM 2725 O  O   . HOH J 5 .   ? -60.09825 14.38416  13.10221  1.000 30.53156 ? 618 HOH A O   1 
HETATM 2726 O  O   . HOH J 5 .   ? -37.82827 2.56612   37.97605  1.000 24.88121 ? 619 HOH A O   1 
HETATM 2727 O  O   . HOH J 5 .   ? -41.81404 19.01095  -1.23760  1.000 24.35390 ? 620 HOH A O   1 
HETATM 2728 O  O   . HOH J 5 .   ? -29.43687 27.69987  48.30816  1.000 34.26099 ? 621 HOH A O   1 
HETATM 2729 O  O   . HOH J 5 .   ? -12.84466 -18.59424 43.59333  1.000 40.43585 ? 622 HOH A O   1 
HETATM 2730 O  O   . HOH J 5 .   ? -44.71059 7.37815   11.73359  1.000 24.19949 ? 623 HOH A O   1 
HETATM 2731 O  O   . HOH J 5 .   ? -25.90374 17.27221  38.71078  1.000 23.21025 ? 624 HOH A O   1 
HETATM 2732 O  O   . HOH J 5 .   ? -30.10575 0.85530   36.17105  1.000 24.12755 ? 625 HOH A O   1 
HETATM 2733 O  O   . HOH J 5 .   ? -40.39166 11.55224  -2.55698  1.000 33.09682 ? 626 HOH A O   1 
HETATM 2734 O  O   . HOH J 5 .   ? -41.090   25.295    10.598    1.000 21.73504 ? 627 HOH A O   1 
HETATM 2735 O  O   . HOH J 5 .   ? -49.76197 9.12060   40.77003  1.000 34.92706 ? 628 HOH A O   1 
HETATM 2736 O  O   . HOH J 5 .   ? -24.77258 1.14681   36.99140  1.000 19.18128 ? 629 HOH A O   1 
HETATM 2737 O  O   . HOH J 5 .   ? -13.63339 -8.65582  30.31888  1.000 40.71020 ? 630 HOH A O   1 
HETATM 2738 O  O   . HOH J 5 .   ? -27.22068 -4.04393  48.20042  1.000 49.72846 ? 631 HOH A O   1 
HETATM 2739 O  O   . HOH J 5 .   ? -26.64556 4.39735   23.23559  1.000 20.69520 ? 632 HOH A O   1 
HETATM 2740 O  O   . HOH J 5 .   ? -26.83663 7.38666   49.88918  1.000 29.08461 ? 633 HOH A O   1 
HETATM 2741 O  O   . HOH J 5 .   ? -42.18402 21.80338  23.42551  1.000 25.61950 ? 634 HOH A O   1 
HETATM 2742 O  O   . HOH J 5 .   ? -20.07084 -15.65748 47.23656  1.000 44.10657 ? 635 HOH A O   1 
HETATM 2743 O  O   . HOH J 5 .   ? -41.97083 16.85122  47.82811  1.000 23.45543 ? 636 HOH A O   1 
HETATM 2744 O  O   . HOH J 5 .   ? -54.44671 11.37967  17.95630  1.000 34.89060 ? 637 HOH A O   1 
HETATM 2745 O  O   . HOH J 5 .   ? -44.034   24.665    41.405    1.000 23.69628 ? 638 HOH A O   1 
HETATM 2746 O  O   . HOH J 5 .   ? -53.445   -8.092    42.693    1.000 50.14532 ? 639 HOH A O   1 
HETATM 2747 O  O   . HOH J 5 .   ? -14.58080 4.83661   45.03729  1.000 40.69506 ? 640 HOH A O   1 
HETATM 2748 O  O   . HOH J 5 .   ? -24.20679 12.74519  54.39808  1.000 41.58390 ? 641 HOH A O   1 
HETATM 2749 O  O   . HOH J 5 .   ? -28.507   -7.704    37.023    1.000 30.96025 ? 642 HOH A O   1 
HETATM 2750 O  O   . HOH J 5 .   ? -26.73233 5.00928   20.81199  1.000 34.49401 ? 643 HOH A O   1 
HETATM 2751 O  O   . HOH J 5 .   ? -43.63072 26.09189  29.79561  1.000 35.27395 ? 644 HOH A O   1 
HETATM 2752 O  O   . HOH J 5 .   ? -26.23942 -9.27973  38.21559  1.000 30.05139 ? 645 HOH A O   1 
HETATM 2753 O  O   . HOH J 5 .   ? -19.89901 8.70972   25.86385  1.000 32.09493 ? 646 HOH A O   1 
HETATM 2754 O  O   . HOH J 5 .   ? -31.358   8.261     5.390     1.000 36.91614 ? 647 HOH A O   1 
HETATM 2755 O  O   . HOH J 5 .   ? -23.98854 15.10155  42.12556  1.000 44.51487 ? 648 HOH A O   1 
HETATM 2756 O  O   . HOH J 5 .   ? -58.41301 23.40920  13.37338  1.000 41.34609 ? 649 HOH A O   1 
HETATM 2757 O  O   . HOH J 5 .   ? -44.51964 22.60591  47.15384  1.000 24.69660 ? 650 HOH A O   1 
HETATM 2758 O  O   . HOH J 5 .   ? -28.32174 16.95737  54.87380  1.000 40.33487 ? 651 HOH A O   1 
HETATM 2759 O  O   . HOH J 5 .   ? -45.63534 15.05671  37.51969  1.000 21.16582 ? 652 HOH A O   1 
HETATM 2760 O  O   . HOH J 5 .   ? -59.12275 17.75677  16.12404  1.000 33.93171 ? 653 HOH A O   1 
HETATM 2761 O  O   . HOH J 5 .   ? -39.10117 6.79818   8.00114   1.000 26.23304 ? 654 HOH A O   1 
HETATM 2762 O  O   . HOH J 5 .   ? -54.05426 8.43666   26.16172  1.000 32.90587 ? 655 HOH A O   1 
HETATM 2763 O  O   . HOH J 5 .   ? -47.002   -5.226    43.244    1.000 42.80575 ? 656 HOH A O   1 
HETATM 2764 O  O   . HOH J 5 .   ? -22.94341 13.19646  34.90495  1.000 21.89306 ? 657 HOH A O   1 
HETATM 2765 O  O   . HOH J 5 .   ? -32.27577 19.96322  14.05995  1.000 29.08481 ? 658 HOH A O   1 
HETATM 2766 O  O   . HOH J 5 .   ? -54.72210 13.90585  35.02681  1.000 33.99947 ? 659 HOH A O   1 
HETATM 2767 O  O   . HOH J 5 .   ? -43.85681 15.12640  0.47236   1.000 31.99655 ? 660 HOH A O   1 
HETATM 2768 O  O   . HOH J 5 .   ? -30.70761 23.09603  40.20962  1.000 32.32798 ? 661 HOH A O   1 
HETATM 2769 O  O   . HOH J 5 .   ? -13.24995 -24.85394 45.22464  1.000 42.98513 ? 662 HOH A O   1 
HETATM 2770 O  O   . HOH J 5 .   ? -41.91804 7.97482   -2.78107  1.000 37.43959 ? 663 HOH A O   1 
HETATM 2771 O  O   . HOH J 5 .   ? -30.43229 21.25223  19.13078  1.000 38.54445 ? 664 HOH A O   1 
HETATM 2772 O  O   . HOH J 5 .   ? -15.70767 9.04877   31.82872  1.000 35.70015 ? 665 HOH A O   1 
HETATM 2773 O  O   . HOH J 5 .   ? -27.095   1.802     22.803    1.000 39.17446 ? 666 HOH A O   1 
HETATM 2774 O  O   . HOH J 5 .   ? -20.43339 15.50697  48.31949  1.000 43.41429 ? 667 HOH A O   1 
HETATM 2775 O  O   . HOH J 5 .   ? -30.06310 -1.78520  47.21568  1.000 26.53264 ? 668 HOH A O   1 
HETATM 2776 O  O   . HOH J 5 .   ? -44.13061 20.13283  17.18529  1.000 38.84737 ? 669 HOH A O   1 
HETATM 2777 O  O   . HOH J 5 .   ? -45.90244 4.94411   36.79681  1.000 37.37891 ? 670 HOH A O   1 
HETATM 2778 O  O   . HOH J 5 .   ? -43.67071 23.04633  26.21942  1.000 23.55095 ? 671 HOH A O   1 
HETATM 2779 O  O   . HOH J 5 .   ? -36.10198 15.75101  50.90501  1.000 27.38081 ? 672 HOH A O   1 
HETATM 2780 O  O   . HOH J 5 .   ? -42.01143 28.05760  36.95581  1.000 28.77834 ? 673 HOH A O   1 
HETATM 2781 O  O   . HOH J 5 .   ? -30.60096 2.15593   53.38866  1.000 30.98254 ? 674 HOH A O   1 
HETATM 2782 O  O   . HOH J 5 .   ? -23.98214 13.87819  37.29692  1.000 30.77703 ? 675 HOH A O   1 
HETATM 2783 O  O   . HOH J 5 .   ? -41.26838 14.75635  40.27010  1.000 19.03329 ? 676 HOH A O   1 
HETATM 2784 O  O   . HOH J 5 .   ? -17.49230 -15.58545 46.15719  1.000 42.55397 ? 677 HOH A O   1 
HETATM 2785 O  O   . HOH J 5 .   ? -47.02978 5.99397   22.27205  1.000 29.29911 ? 678 HOH A O   1 
HETATM 2786 O  O   . HOH J 5 .   ? -30.89553 -1.61612  34.90653  1.000 20.92203 ? 679 HOH A O   1 
HETATM 2787 O  O   . HOH J 5 .   ? -25.62593 -8.96040  47.72585  1.000 37.84961 ? 680 HOH A O   1 
HETATM 2788 O  O   . HOH J 5 .   ? -25.82844 16.74809  29.50674  1.000 25.75830 ? 681 HOH A O   1 
HETATM 2789 O  O   . HOH J 5 .   ? -47.17697 15.87670  41.86729  1.000 27.88268 ? 682 HOH A O   1 
HETATM 2790 O  O   . HOH J 5 .   ? -45.60919 25.48060  31.68403  1.000 26.64059 ? 683 HOH A O   1 
HETATM 2791 O  O   . HOH J 5 .   ? -10.30358 4.77907   41.03000  1.000 33.24045 ? 684 HOH A O   1 
HETATM 2792 O  O   . HOH J 5 .   ? -42.22482 1.55360   31.35107  1.000 31.27813 ? 685 HOH A O   1 
HETATM 2793 O  O   . HOH J 5 .   ? -45.10332 5.44039   7.36528   1.000 34.20412 ? 686 HOH A O   1 
HETATM 2794 O  O   . HOH J 5 .   ? -46.13804 22.27029  13.63322  1.000 25.36428 ? 687 HOH A O   1 
HETATM 2795 O  O   . HOH J 5 .   ? -51.60666 18.35246  39.58055  1.000 34.83254 ? 688 HOH A O   1 
HETATM 2796 O  O   . HOH J 5 .   ? -24.73160 11.51419  38.33983  1.000 34.18557 ? 689 HOH A O   1 
HETATM 2797 O  O   . HOH J 5 .   ? -47.53854 18.27057  40.77058  1.000 20.36474 ? 690 HOH A O   1 
HETATM 2798 O  O   . HOH J 5 .   ? -35.12766 -4.55114  46.26607  1.000 32.86351 ? 691 HOH A O   1 
HETATM 2799 O  O   . HOH J 5 .   ? -23.19032 4.07847   47.10432  1.000 24.32992 ? 692 HOH A O   1 
HETATM 2800 O  O   . HOH J 5 .   ? -41.18551 3.26662   29.81917  1.000 38.39262 ? 693 HOH A O   1 
HETATM 2801 O  O   . HOH J 5 .   ? -27.86915 19.35456  27.78324  1.000 43.70593 ? 694 HOH A O   1 
HETATM 2802 O  O   . HOH J 5 .   ? -31.98800 25.44680  26.93780  1.000 33.56756 ? 695 HOH A O   1 
HETATM 2803 O  O   . HOH J 5 .   ? -34.34708 15.03240  57.93486  1.000 44.58556 ? 696 HOH A O   1 
HETATM 2804 O  O   . HOH J 5 .   ? -24.893   -20.675   47.801    1.000 41.58931 ? 697 HOH A O   1 
HETATM 2805 O  O   . HOH J 5 .   ? -16.41956 -9.50413  28.25545  1.000 31.90589 ? 698 HOH A O   1 
HETATM 2806 O  O   . HOH J 5 .   ? -40.62939 8.58093   51.82509  1.000 39.18199 ? 699 HOH A O   1 
HETATM 2807 O  O   . HOH J 5 .   ? -28.27052 3.58144   52.48370  1.000 36.34899 ? 700 HOH A O   1 
HETATM 2808 O  O   . HOH J 5 .   ? -29.99783 23.65106  44.49073  1.000 25.33545 ? 701 HOH A O   1 
HETATM 2809 O  O   . HOH J 5 .   ? -31.53805 -1.71558  30.04771  1.000 32.41169 ? 702 HOH A O   1 
HETATM 2810 O  O   . HOH J 5 .   ? -27.52114 17.58660  40.79057  1.000 26.35687 ? 703 HOH A O   1 
HETATM 2811 O  O   . HOH J 5 .   ? -48.15433 26.44232  11.55124  1.000 26.44914 ? 704 HOH A O   1 
HETATM 2812 O  O   . HOH J 5 .   ? -36.66995 27.56291  39.83711  1.000 33.24549 ? 705 HOH A O   1 
HETATM 2813 O  O   . HOH J 5 .   ? -28.87610 19.14793  54.78295  1.000 41.06425 ? 706 HOH A O   1 
HETATM 2814 O  O   . HOH J 5 .   ? -29.52599 5.66131   14.32579  1.000 38.25027 ? 707 HOH A O   1 
HETATM 2815 O  O   . HOH J 5 .   ? -28.11167 -5.52522  35.58421  1.000 25.12713 ? 708 HOH A O   1 
HETATM 2816 O  O   . HOH J 5 .   ? -24.14339 6.45951   20.10122  1.000 38.36993 ? 709 HOH A O   1 
HETATM 2817 O  O   . HOH J 5 .   ? -28.41752 20.35385  37.48230  1.000 31.34396 ? 710 HOH A O   1 
HETATM 2818 O  O   . HOH J 5 .   ? -70.631   26.444    -8.138    1.000 34.99654 ? 711 HOH A O   1 
HETATM 2819 O  O   . HOH J 5 .   ? -48.28616 6.87051   12.69094  1.000 32.31975 ? 712 HOH A O   1 
HETATM 2820 O  O   . HOH J 5 .   ? -38.61494 -2.31268  52.10870  1.000 34.54927 ? 713 HOH A O   1 
HETATM 2821 O  O   . HOH J 5 .   ? -34.68803 23.58455  19.95272  1.000 31.29508 ? 714 HOH A O   1 
HETATM 2822 O  O   . HOH J 5 .   ? -55.97614 9.12103   1.92396   1.000 41.17510 ? 715 HOH A O   1 
HETATM 2823 O  O   . HOH J 5 .   ? -65.82096 21.92788  -4.48287  1.000 33.77050 ? 716 HOH A O   1 
HETATM 2824 O  O   . HOH J 5 .   ? -23.15293 -18.45456 36.40134  1.000 38.93806 ? 717 HOH A O   1 
HETATM 2825 O  O   . HOH J 5 .   ? -22.57442 -16.43050 37.97756  1.000 40.62977 ? 718 HOH A O   1 
HETATM 2826 O  O   . HOH J 5 .   ? -56.94260 15.00210  18.49847  1.000 31.19890 ? 719 HOH A O   1 
HETATM 2827 O  O   . HOH J 5 .   ? -24.82847 16.57897  55.36931  1.000 44.42970 ? 720 HOH A O   1 
HETATM 2828 O  O   . HOH J 5 .   ? -24.964   1.261     23.944    1.000 38.03751 ? 721 HOH A O   1 
HETATM 2829 O  O   . HOH J 5 .   ? -50.64628 4.66961   39.05855  1.000 40.27250 ? 722 HOH A O   1 
HETATM 2830 O  O   . HOH J 5 .   ? -36.92031 28.90605  32.37925  1.000 42.86442 ? 723 HOH A O   1 
HETATM 2831 O  O   . HOH J 5 .   ? -56.79823 10.62465  17.33688  1.000 38.75144 ? 724 HOH A O   1 
HETATM 2832 O  O   . HOH J 5 .   ? -37.82609 20.57667  56.31763  1.000 38.10938 ? 725 HOH A O   1 
HETATM 2833 O  O   . HOH J 5 .   ? -59.15571 28.88548  -4.20984  1.000 40.44357 ? 726 HOH A O   1 
HETATM 2834 O  O   . HOH J 5 .   ? -45.20389 16.39301  -1.02395  1.000 42.48803 ? 727 HOH A O   1 
HETATM 2835 O  O   . HOH J 5 .   ? -50.31723 31.07380  8.78529   1.000 36.46117 ? 728 HOH A O   1 
HETATM 2836 O  O   . HOH J 5 .   ? -17.16269 13.04904  34.22000  1.000 37.39563 ? 729 HOH A O   1 
HETATM 2837 O  O   . HOH J 5 .   ? -26.96006 -3.36604  32.10145  1.000 37.36654 ? 730 HOH A O   1 
HETATM 2838 O  O   . HOH J 5 .   ? -34.72293 -0.43359  26.16685  1.000 37.29736 ? 731 HOH A O   1 
HETATM 2839 O  O   . HOH J 5 .   ? -59.68415 11.51299  13.62019  1.000 42.75236 ? 732 HOH A O   1 
HETATM 2840 O  O   . HOH J 5 .   ? -44.37103 24.09143  19.88942  1.000 48.57738 ? 733 HOH A O   1 
HETATM 2841 O  O   . HOH J 5 .   ? -35.42303 13.57417  2.21360   1.000 32.45663 ? 734 HOH A O   1 
HETATM 2842 O  O   . HOH J 5 .   ? -51.32565 1.46710   32.41605  1.000 35.03264 ? 735 HOH A O   1 
HETATM 2843 O  O   . HOH J 5 .   ? -32.654   27.013    55.531    1.000 42.30742 ? 736 HOH A O   1 
HETATM 2844 O  O   . HOH J 5 .   ? -24.08334 17.33551  45.53308  1.000 43.23526 ? 737 HOH A O   1 
HETATM 2845 O  O   . HOH J 5 .   ? -22.46718 11.09404  43.29141  1.000 30.46979 ? 738 HOH A O   1 
HETATM 2846 O  O   . HOH J 5 .   ? -19.57782 1.17787   22.70701  1.000 38.89055 ? 739 HOH A O   1 
HETATM 2847 O  O   . HOH J 5 .   ? -26.45611 2.16842   51.39984  1.000 42.01123 ? 740 HOH A O   1 
HETATM 2848 O  O   . HOH J 5 .   ? -35.00226 17.44230  58.16421  1.000 41.81906 ? 741 HOH A O   1 
HETATM 2849 O  O   . HOH J 5 .   ? -56.62627 20.02449  21.08043  1.000 38.95662 ? 742 HOH A O   1 
HETATM 2850 O  O   . HOH J 5 .   ? -26.19955 -26.97746 39.24020  1.000 42.88448 ? 743 HOH A O   1 
HETATM 2851 O  O   . HOH J 5 .   ? -32.57985 -7.01079  43.97178  1.000 36.96371 ? 744 HOH A O   1 
HETATM 2852 O  O   . HOH J 5 .   ? -70.67541 19.62004  -4.83835  1.000 46.36746 ? 745 HOH A O   1 
HETATM 2853 O  O   . HOH J 5 .   ? -56.98621 30.09462  -3.45585  1.000 43.57833 ? 746 HOH A O   1 
HETATM 2854 O  O   . HOH J 5 .   ? -33.791   17.956    4.162     1.000 40.51664 ? 747 HOH A O   1 
HETATM 2855 O  O   . HOH J 5 .   ? -28.72936 16.59375  23.45902  1.000 14.16503 ? 748 HOH A O   1 
HETATM 2856 O  O   . HOH J 5 .   ? -43.91380 25.66048  14.77550  1.000 44.37544 ? 749 HOH A O   1 
HETATM 2857 O  O   . HOH J 5 .   ? -39.79802 16.57777  54.39229  1.000 44.23486 ? 750 HOH A O   1 
HETATM 2858 O  O   . HOH J 5 .   ? -36.343   25.850    57.106    1.000 37.52344 ? 751 HOH A O   1 
HETATM 2859 O  O   . HOH J 5 .   ? -16.10001 10.95502  40.28359  1.000 45.23255 ? 752 HOH A O   1 
HETATM 2860 O  O   . HOH J 5 .   ? -23.68232 20.43631  49.88269  1.000 36.86108 ? 753 HOH A O   1 
HETATM 2861 O  O   . HOH J 5 .   ? -44.46767 23.74239  23.51289  1.000 42.40345 ? 754 HOH A O   1 
HETATM 2862 O  O   . HOH J 5 .   ? -40.76661 21.00986  16.54554  1.000 35.44460 ? 755 HOH A O   1 
HETATM 2863 O  O   . HOH J 5 .   ? -28.92348 -3.38938  33.99855  1.000 20.31480 ? 756 HOH A O   1 
HETATM 2864 O  O   . HOH J 5 .   ? -43.45884 -2.06526  45.03839  1.000 42.56676 ? 757 HOH A O   1 
HETATM 2865 O  O   . HOH J 5 .   ? -50.38395 5.76191   15.84076  1.000 41.05431 ? 758 HOH A O   1 
HETATM 2866 O  O   . HOH J 5 .   ? -32.03459 26.29075  29.34080  1.000 38.72983 ? 759 HOH A O   1 
HETATM 2867 O  O   . HOH J 5 .   ? -16.46169 11.79990  32.33388  1.000 39.37791 ? 760 HOH A O   1 
HETATM 2868 O  O   . HOH J 5 .   ? -40.76062 18.75772  54.82046  1.000 32.13380 ? 761 HOH A O   1 
HETATM 2869 O  O   . HOH J 5 .   ? -53.26227 9.19070   23.68734  1.000 31.77136 ? 762 HOH A O   1 
HETATM 2870 O  O   . HOH J 5 .   ? -20.53033 -19.56951 35.71668  1.000 52.90251 ? 763 HOH A O   1 
HETATM 2871 O  O   . HOH J 5 .   ? -59.16189 9.57680   5.72535   1.000 41.70078 ? 764 HOH A O   1 
HETATM 2872 O  O   . HOH J 5 .   ? -45.96747 14.13881  39.88457  1.000 25.11333 ? 765 HOH A O   1 
HETATM 2873 O  O   . HOH J 5 .   ? -16.67886 8.35352   29.62269  1.000 33.94858 ? 766 HOH A O   1 
HETATM 2874 O  O   . HOH J 5 .   ? -67.76086 19.91894  -3.26099  1.000 41.50418 ? 767 HOH A O   1 
HETATM 2875 O  O   . HOH J 5 .   ? -38.641   3.907     5.707     1.000 44.73597 ? 768 HOH A O   1 
HETATM 2876 O  O   . HOH J 5 .   ? -25.14957 21.38911  45.40278  1.000 39.63304 ? 769 HOH A O   1 
HETATM 2877 O  O   . HOH J 5 .   ? -33.76490 15.83814  6.69235   1.000 31.23101 ? 770 HOH A O   1 
HETATM 2878 O  O   . HOH J 5 .   ? -25.49481 18.30639  34.89037  1.000 43.24888 ? 771 HOH A O   1 
HETATM 2879 O  O   . HOH J 5 .   ? -38.54410 20.44825  19.41788  1.000 29.93115 ? 772 HOH A O   1 
HETATM 2880 O  O   . HOH J 5 .   ? -60.80898 32.45320  9.52364   1.000 43.92915 ? 773 HOH A O   1 
HETATM 2881 O  O   . HOH J 5 .   ? -29.340   -20.888   46.149    1.000 35.71718 ? 774 HOH A O   1 
HETATM 2882 O  O   . HOH J 5 .   ? -20.56709 9.55983   27.81633  1.000 30.80541 ? 775 HOH A O   1 
HETATM 2883 O  O   . HOH J 5 .   ? -29.87552 -9.17925  40.83374  1.000 38.95271 ? 776 HOH A O   1 
HETATM 2884 O  O   . HOH J 5 .   ? -28.48088 -2.48030  49.41049  1.000 48.06997 ? 777 HOH A O   1 
HETATM 2885 O  O   . HOH J 5 .   ? -32.87407 15.96983  10.69834  1.000 25.64074 ? 778 HOH A O   1 
HETATM 2886 O  O   . HOH J 5 .   ? -42.14031 10.72202  52.05849  1.000 39.36368 ? 779 HOH A O   1 
HETATM 2887 O  O   . HOH J 5 .   ? -22.07997 13.05795  44.34435  1.000 38.42695 ? 780 HOH A O   1 
HETATM 2888 O  O   . HOH J 5 .   ? -53.36899 7.24629   21.91394  1.000 36.31345 ? 781 HOH A O   1 
HETATM 2889 O  O   . HOH J 5 .   ? -52.28321 19.85020  33.70075  1.000 41.14079 ? 782 HOH A O   1 
HETATM 2890 O  O   . HOH J 5 .   ? -51.17284 6.81126   20.84189  1.000 27.72680 ? 783 HOH A O   1 
HETATM 2891 O  O   . HOH J 5 .   ? -22.39889 -8.69279  33.32562  1.000 38.97199 ? 784 HOH A O   1 
HETATM 2892 O  O   . HOH J 5 .   ? -24.546   6.019     17.317    1.000 43.75005 ? 785 HOH A O   1 
HETATM 2893 O  O   . HOH J 5 .   ? -49.77457 19.34351  41.13660  1.000 31.01917 ? 786 HOH A O   1 
HETATM 2894 O  O   . HOH J 5 .   ? -23.14346 16.02767  39.00855  1.000 42.58425 ? 787 HOH A O   1 
HETATM 2895 O  O   . HOH J 5 .   ? -42.65463 5.10989   8.71247   1.000 34.67468 ? 788 HOH A O   1 
HETATM 2896 O  O   . HOH J 5 .   ? -29.48941 21.14125  25.59009  1.000 37.61045 ? 789 HOH A O   1 
HETATM 2897 O  O   . HOH J 5 .   ? -37.20162 22.68872  18.17935  1.000 36.36950 ? 790 HOH A O   1 
HETATM 2898 O  O   . HOH J 5 .   ? -25.37782 -5.63386  34.31736  1.000 31.52300 ? 791 HOH A O   1 
HETATM 2899 O  O   . HOH J 5 .   ? -9.57127  -8.00530  38.32932  1.000 37.46003 ? 792 HOH A O   1 
HETATM 2900 O  O   . HOH J 5 .   ? -49.00383 15.27697  47.48066  1.000 39.79176 ? 793 HOH A O   1 
HETATM 2901 O  O   . HOH J 5 .   ? -33.49232 14.55448  4.30888   1.000 36.42066 ? 794 HOH A O   1 
HETATM 2902 O  O   . HOH J 5 .   ? -25.65380 19.65207  37.57726  1.000 45.38331 ? 795 HOH A O   1 
HETATM 2903 O  O   . HOH J 5 .   ? -28.10994 24.91945  33.29006  1.000 49.55512 ? 796 HOH A O   1 
HETATM 2904 O  O   . HOH J 5 .   ? -26.142   5.934     13.104    1.000 38.34415 ? 797 HOH A O   1 
HETATM 2905 O  O   . HOH J 5 .   ? -12.90287 -17.42446 45.74829  1.000 50.56555 ? 798 HOH A O   1 
HETATM 2906 O  O   . HOH J 5 .   ? -28.94970 24.51225  42.05899  1.000 44.12219 ? 799 HOH A O   1 
HETATM 2907 O  O   . HOH J 5 .   ? -42.56298 16.36253  54.15365  1.000 43.11716 ? 800 HOH A O   1 
HETATM 2908 O  O   . HOH J 5 .   ? -30.87306 14.92551  6.01444   1.000 44.92509 ? 801 HOH A O   1 
HETATM 2909 O  O   . HOH J 5 .   ? -29.352   11.586    3.920     1.000 41.43213 ? 802 HOH A O   1 
HETATM 2910 O  O   . HOH J 5 .   ? -62.52771 15.22006  13.97137  1.000 35.02671 ? 803 HOH A O   1 
HETATM 2911 O  O   . HOH J 5 .   ? -20.05197 -17.59292 38.85841  1.000 33.46609 ? 804 HOH A O   1 
HETATM 2912 O  O   . HOH J 5 .   ? -45.17460 24.74873  27.72805  1.000 36.11657 ? 805 HOH A O   1 
HETATM 2913 O  O   . HOH J 5 .   ? -47.338   24.313    37.894    1.000 28.59458 ? 806 HOH A O   1 
HETATM 2914 O  O   . HOH J 5 .   ? -32.88222 -4.07828  47.63184  1.000 34.49901 ? 807 HOH A O   1 
HETATM 2915 O  O   . HOH J 5 .   ? -32.55724 -1.64974  47.95646  1.000 34.67152 ? 808 HOH A O   1 
HETATM 2916 O  O   . HOH J 5 .   ? -31.355   18.914    3.871     1.000 31.75307 ? 809 HOH A O   1 
HETATM 2917 O  O   . HOH J 5 .   ? -46.338   25.360    39.832    1.000 22.77972 ? 810 HOH A O   1 
HETATM 2918 O  O   . HOH J 5 .   ? -32.18625 18.32485  11.97299  1.000 33.35664 ? 811 HOH A O   1 
HETATM 2919 O  O   . HOH J 5 .   ? -22.31462 -14.40765 36.12464  1.000 36.35902 ? 812 HOH A O   1 
HETATM 2920 O  O   . HOH J 5 .   ? -50.76596 3.95107   20.73588  1.000 37.35447 ? 813 HOH A O   1 
# 
