data_8VA9
# 
_entry.id   8VA9 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8VA9         pdb_00008va9 10.2210/pdb8va9/pdb 
WWPDB D_1000279823 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume' 
2 2 'Structure model' '_citation.page_first'     
3 2 'Structure model' '_citation.page_last'      
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8VA9 
_pdbx_database_status.recvd_initial_deposition_date   2023-12-11 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              tmmakris@ncsu.edu 
_pdbx_contact_author.name_first         Thomas 
_pdbx_contact_author.name_last          Makris 
_pdbx_contact_author.name_mi            M 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7927-620X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Phan, H.N.'   1 0000-0002-2949-8944 
'Swartz, P.D.' 2 ?                   
'Makris, T.M.' 3 0000-0001-7927-620X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochemistry 
_citation.journal_id_ASTM           BICHAW 
_citation.journal_id_CSD            0033 
_citation.journal_id_ISSN           0006-2960 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            63 
_citation.language                  ? 
_citation.page_first                3020 
_citation.page_last                 3029 
_citation.title                     
;Assembly of a Heterobimetallic Fe/Mn Cofactor in the para -Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.biochem.4c00326 
_citation.pdbx_database_id_PubMed   39471288 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Phan, H.N.'       1 0000-0002-2949-8944 
primary 'Swartz, P.D.'     2 ?                   
primary 'Gangopadhyay, M.' 3 0009-0006-4739-6833 
primary 'Guo, Y.'          4 0000-0002-4132-3565 
primary 'Smirnov, A.I.'    5 0000-0002-0037-2555 
primary 'Makris, T.M.'     6 0000-0001-7927-620X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '4-aminobenzoate synthase' 27769.285 2  ? ? ? ? 
2 non-polymer syn 'FE (II) ION'              55.845    2  ? ? ? ? 
3 non-polymer syn 'MANGANESE (II) ION'       54.938    2  ? ? ? ? 
4 non-polymer syn GLYCEROL                   92.094    1  ? ? ? ? 
5 water       nat water                      18.015    65 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMMEVFMNFLDQLDLIIQNKHMLEHTFYVKWSKGELTKEQLQAYAKDYYLHIKAFPKYLSA
IHSRCDDLEARKLLLDNLMDEENGYPNHIDLWKQFVFALGVTPEELEAHEPSEAAKAKVATFMRWCTGDSLAAGVAALYS
YESQIPRIAREKIRGLTEYFGFSNPEDYAYFTEHEEADVRHAREEKALIEMLLKDDADKVLEASQEVTQSLYGFLDSFLD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMMEVFMNFLDQLDLIIQNKHMLEHTFYVKWSKGELTKEQLQAYAKDYYLHIKAFPKYLSA
IHSRCDDLEARKLLLDNLMDEENGYPNHIDLWKQFVFALGVTPEELEAHEPSEAAKAKVATFMRWCTGDSLAAGVAALYS
YESQIPRIAREKIRGLTEYFGFSNPEDYAYFTEHEEADVRHAREEKALIEMLLKDDADKVLEASQEVTQSLYGFLDSFLD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'FE (II) ION'        FE2 
3 'MANGANESE (II) ION' MN  
4 GLYCEROL             GOL 
5 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  MET n 
1 23  GLU n 
1 24  VAL n 
1 25  PHE n 
1 26  MET n 
1 27  ASN n 
1 28  PHE n 
1 29  LEU n 
1 30  ASP n 
1 31  GLN n 
1 32  LEU n 
1 33  ASP n 
1 34  LEU n 
1 35  ILE n 
1 36  ILE n 
1 37  GLN n 
1 38  ASN n 
1 39  LYS n 
1 40  HIS n 
1 41  MET n 
1 42  LEU n 
1 43  GLU n 
1 44  HIS n 
1 45  THR n 
1 46  PHE n 
1 47  TYR n 
1 48  VAL n 
1 49  LYS n 
1 50  TRP n 
1 51  SER n 
1 52  LYS n 
1 53  GLY n 
1 54  GLU n 
1 55  LEU n 
1 56  THR n 
1 57  LYS n 
1 58  GLU n 
1 59  GLN n 
1 60  LEU n 
1 61  GLN n 
1 62  ALA n 
1 63  TYR n 
1 64  ALA n 
1 65  LYS n 
1 66  ASP n 
1 67  TYR n 
1 68  TYR n 
1 69  LEU n 
1 70  HIS n 
1 71  ILE n 
1 72  LYS n 
1 73  ALA n 
1 74  PHE n 
1 75  PRO n 
1 76  LYS n 
1 77  TYR n 
1 78  LEU n 
1 79  SER n 
1 80  ALA n 
1 81  ILE n 
1 82  HIS n 
1 83  SER n 
1 84  ARG n 
1 85  CYS n 
1 86  ASP n 
1 87  ASP n 
1 88  LEU n 
1 89  GLU n 
1 90  ALA n 
1 91  ARG n 
1 92  LYS n 
1 93  LEU n 
1 94  LEU n 
1 95  LEU n 
1 96  ASP n 
1 97  ASN n 
1 98  LEU n 
1 99  MET n 
1 100 ASP n 
1 101 GLU n 
1 102 GLU n 
1 103 ASN n 
1 104 GLY n 
1 105 TYR n 
1 106 PRO n 
1 107 ASN n 
1 108 HIS n 
1 109 ILE n 
1 110 ASP n 
1 111 LEU n 
1 112 TRP n 
1 113 LYS n 
1 114 GLN n 
1 115 PHE n 
1 116 VAL n 
1 117 PHE n 
1 118 ALA n 
1 119 LEU n 
1 120 GLY n 
1 121 VAL n 
1 122 THR n 
1 123 PRO n 
1 124 GLU n 
1 125 GLU n 
1 126 LEU n 
1 127 GLU n 
1 128 ALA n 
1 129 HIS n 
1 130 GLU n 
1 131 PRO n 
1 132 SER n 
1 133 GLU n 
1 134 ALA n 
1 135 ALA n 
1 136 LYS n 
1 137 ALA n 
1 138 LYS n 
1 139 VAL n 
1 140 ALA n 
1 141 THR n 
1 142 PHE n 
1 143 MET n 
1 144 ARG n 
1 145 TRP n 
1 146 CYS n 
1 147 THR n 
1 148 GLY n 
1 149 ASP n 
1 150 SER n 
1 151 LEU n 
1 152 ALA n 
1 153 ALA n 
1 154 GLY n 
1 155 VAL n 
1 156 ALA n 
1 157 ALA n 
1 158 LEU n 
1 159 TYR n 
1 160 SER n 
1 161 TYR n 
1 162 GLU n 
1 163 SER n 
1 164 GLN n 
1 165 ILE n 
1 166 PRO n 
1 167 ARG n 
1 168 ILE n 
1 169 ALA n 
1 170 ARG n 
1 171 GLU n 
1 172 LYS n 
1 173 ILE n 
1 174 ARG n 
1 175 GLY n 
1 176 LEU n 
1 177 THR n 
1 178 GLU n 
1 179 TYR n 
1 180 PHE n 
1 181 GLY n 
1 182 PHE n 
1 183 SER n 
1 184 ASN n 
1 185 PRO n 
1 186 GLU n 
1 187 ASP n 
1 188 TYR n 
1 189 ALA n 
1 190 TYR n 
1 191 PHE n 
1 192 THR n 
1 193 GLU n 
1 194 HIS n 
1 195 GLU n 
1 196 GLU n 
1 197 ALA n 
1 198 ASP n 
1 199 VAL n 
1 200 ARG n 
1 201 HIS n 
1 202 ALA n 
1 203 ARG n 
1 204 GLU n 
1 205 GLU n 
1 206 LYS n 
1 207 ALA n 
1 208 LEU n 
1 209 ILE n 
1 210 GLU n 
1 211 MET n 
1 212 LEU n 
1 213 LEU n 
1 214 LYS n 
1 215 ASP n 
1 216 ASP n 
1 217 ALA n 
1 218 ASP n 
1 219 LYS n 
1 220 VAL n 
1 221 LEU n 
1 222 GLU n 
1 223 ALA n 
1 224 SER n 
1 225 GLN n 
1 226 GLU n 
1 227 VAL n 
1 228 THR n 
1 229 GLN n 
1 230 SER n 
1 231 LEU n 
1 232 TYR n 
1 233 GLY n 
1 234 PHE n 
1 235 LEU n 
1 236 ASP n 
1 237 SER n 
1 238 PHE n 
1 239 LEU n 
1 240 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   240 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CT_610 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    'Strain D/UW-3/Cx' 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Chlamydia trachomatis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     813 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE              ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE             ?                               'C3 H7 N O2 S'   121.158 
FE2 non-polymer         . 'FE (II) ION'        ?                               'Fe 2'           55.845  
GLN 'L-peptide linking' y GLUTAMINE            ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL             'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE            ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE              ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ?                               'C5 H11 N O2 S'  149.211 
MN  non-polymer         . 'MANGANESE (II) ION' ?                               'Mn 2'           54.938  
PHE 'L-peptide linking' y PHENYLALANINE        ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE            ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -19 ?   ?   ?   A . n 
A 1 2   GLY 2   -18 ?   ?   ?   A . n 
A 1 3   SER 3   -17 ?   ?   ?   A . n 
A 1 4   SER 4   -16 ?   ?   ?   A . n 
A 1 5   HIS 5   -15 ?   ?   ?   A . n 
A 1 6   HIS 6   -14 ?   ?   ?   A . n 
A 1 7   HIS 7   -13 ?   ?   ?   A . n 
A 1 8   HIS 8   -12 ?   ?   ?   A . n 
A 1 9   HIS 9   -11 ?   ?   ?   A . n 
A 1 10  HIS 10  -10 ?   ?   ?   A . n 
A 1 11  SER 11  -9  ?   ?   ?   A . n 
A 1 12  SER 12  -8  ?   ?   ?   A . n 
A 1 13  GLY 13  -7  ?   ?   ?   A . n 
A 1 14  LEU 14  -6  ?   ?   ?   A . n 
A 1 15  VAL 15  -5  ?   ?   ?   A . n 
A 1 16  PRO 16  -4  ?   ?   ?   A . n 
A 1 17  ARG 17  -3  ?   ?   ?   A . n 
A 1 18  GLY 18  -2  ?   ?   ?   A . n 
A 1 19  SER 19  -1  ?   ?   ?   A . n 
A 1 20  HIS 20  0   ?   ?   ?   A . n 
A 1 21  MET 21  1   ?   ?   ?   A . n 
A 1 22  MET 22  2   ?   ?   ?   A . n 
A 1 23  GLU 23  3   ?   ?   ?   A . n 
A 1 24  VAL 24  4   ?   ?   ?   A . n 
A 1 25  PHE 25  5   ?   ?   ?   A . n 
A 1 26  MET 26  6   6   MET MET A . n 
A 1 27  ASN 27  7   7   ASN ASN A . n 
A 1 28  PHE 28  8   8   PHE PHE A . n 
A 1 29  LEU 29  9   9   LEU LEU A . n 
A 1 30  ASP 30  10  10  ASP ASP A . n 
A 1 31  GLN 31  11  11  GLN GLN A . n 
A 1 32  LEU 32  12  12  LEU LEU A . n 
A 1 33  ASP 33  13  13  ASP ASP A . n 
A 1 34  LEU 34  14  14  LEU LEU A . n 
A 1 35  ILE 35  15  15  ILE ILE A . n 
A 1 36  ILE 36  16  16  ILE ILE A . n 
A 1 37  GLN 37  17  17  GLN GLN A . n 
A 1 38  ASN 38  18  18  ASN ASN A . n 
A 1 39  LYS 39  19  19  LYS LYS A . n 
A 1 40  HIS 40  20  20  HIS HIS A . n 
A 1 41  MET 41  21  21  MET MET A . n 
A 1 42  LEU 42  22  22  LEU LEU A . n 
A 1 43  GLU 43  23  23  GLU GLU A . n 
A 1 44  HIS 44  24  24  HIS HIS A . n 
A 1 45  THR 45  25  25  THR THR A . n 
A 1 46  PHE 46  26  26  PHE PHE A . n 
A 1 47  TYR 47  27  27  TYR TYR A . n 
A 1 48  VAL 48  28  28  VAL VAL A . n 
A 1 49  LYS 49  29  29  LYS LYS A . n 
A 1 50  TRP 50  30  30  TRP TRP A . n 
A 1 51  SER 51  31  31  SER SER A . n 
A 1 52  LYS 52  32  32  LYS LYS A . n 
A 1 53  GLY 53  33  33  GLY GLY A . n 
A 1 54  GLU 54  34  34  GLU GLU A . n 
A 1 55  LEU 55  35  35  LEU LEU A . n 
A 1 56  THR 56  36  36  THR THR A . n 
A 1 57  LYS 57  37  37  LYS LYS A . n 
A 1 58  GLU 58  38  38  GLU GLU A . n 
A 1 59  GLN 59  39  39  GLN GLN A . n 
A 1 60  LEU 60  40  40  LEU LEU A . n 
A 1 61  GLN 61  41  41  GLN GLN A . n 
A 1 62  ALA 62  42  42  ALA ALA A . n 
A 1 63  TYR 63  43  43  TYR TYR A . n 
A 1 64  ALA 64  44  44  ALA ALA A . n 
A 1 65  LYS 65  45  45  LYS LYS A . n 
A 1 66  ASP 66  46  46  ASP ASP A . n 
A 1 67  TYR 67  47  47  TYR TYR A . n 
A 1 68  TYR 68  48  48  TYR TYR A . n 
A 1 69  LEU 69  49  49  LEU LEU A . n 
A 1 70  HIS 70  50  50  HIS HIS A . n 
A 1 71  ILE 71  51  51  ILE ILE A . n 
A 1 72  LYS 72  52  52  LYS LYS A . n 
A 1 73  ALA 73  53  53  ALA ALA A . n 
A 1 74  PHE 74  54  54  PHE PHE A . n 
A 1 75  PRO 75  55  55  PRO PRO A . n 
A 1 76  LYS 76  56  56  LYS LYS A . n 
A 1 77  TYR 77  57  57  TYR TYR A . n 
A 1 78  LEU 78  58  58  LEU LEU A . n 
A 1 79  SER 79  59  59  SER SER A . n 
A 1 80  ALA 80  60  60  ALA ALA A . n 
A 1 81  ILE 81  61  61  ILE ILE A . n 
A 1 82  HIS 82  62  62  HIS HIS A . n 
A 1 83  SER 83  63  63  SER SER A . n 
A 1 84  ARG 84  64  64  ARG ARG A . n 
A 1 85  CYS 85  65  65  CYS CYS A . n 
A 1 86  ASP 86  66  66  ASP ASP A . n 
A 1 87  ASP 87  67  67  ASP ASP A . n 
A 1 88  LEU 88  68  68  LEU LEU A . n 
A 1 89  GLU 89  69  69  GLU GLU A . n 
A 1 90  ALA 90  70  70  ALA ALA A . n 
A 1 91  ARG 91  71  71  ARG ARG A . n 
A 1 92  LYS 92  72  72  LYS LYS A . n 
A 1 93  LEU 93  73  73  LEU LEU A . n 
A 1 94  LEU 94  74  74  LEU LEU A . n 
A 1 95  LEU 95  75  75  LEU LEU A . n 
A 1 96  ASP 96  76  76  ASP ASP A . n 
A 1 97  ASN 97  77  77  ASN ASN A . n 
A 1 98  LEU 98  78  78  LEU LEU A . n 
A 1 99  MET 99  79  79  MET MET A . n 
A 1 100 ASP 100 80  80  ASP ASP A . n 
A 1 101 GLU 101 81  81  GLU GLU A . n 
A 1 102 GLU 102 82  82  GLU GLU A . n 
A 1 103 ASN 103 83  83  ASN ASN A . n 
A 1 104 GLY 104 84  84  GLY GLY A . n 
A 1 105 TYR 105 85  85  TYR TYR A . n 
A 1 106 PRO 106 86  86  PRO PRO A . n 
A 1 107 ASN 107 87  87  ASN ASN A . n 
A 1 108 HIS 108 88  88  HIS HIS A . n 
A 1 109 ILE 109 89  89  ILE ILE A . n 
A 1 110 ASP 110 90  90  ASP ASP A . n 
A 1 111 LEU 111 91  91  LEU LEU A . n 
A 1 112 TRP 112 92  92  TRP TRP A . n 
A 1 113 LYS 113 93  93  LYS LYS A . n 
A 1 114 GLN 114 94  94  GLN GLN A . n 
A 1 115 PHE 115 95  95  PHE PHE A . n 
A 1 116 VAL 116 96  96  VAL VAL A . n 
A 1 117 PHE 117 97  97  PHE PHE A . n 
A 1 118 ALA 118 98  98  ALA ALA A . n 
A 1 119 LEU 119 99  99  LEU LEU A . n 
A 1 120 GLY 120 100 100 GLY GLY A . n 
A 1 121 VAL 121 101 101 VAL VAL A . n 
A 1 122 THR 122 102 102 THR THR A . n 
A 1 123 PRO 123 103 103 PRO PRO A . n 
A 1 124 GLU 124 104 104 GLU GLU A . n 
A 1 125 GLU 125 105 105 GLU GLU A . n 
A 1 126 LEU 126 106 106 LEU LEU A . n 
A 1 127 GLU 127 107 107 GLU GLU A . n 
A 1 128 ALA 128 108 108 ALA ALA A . n 
A 1 129 HIS 129 109 109 HIS HIS A . n 
A 1 130 GLU 130 110 110 GLU GLU A . n 
A 1 131 PRO 131 111 111 PRO PRO A . n 
A 1 132 SER 132 112 112 SER SER A . n 
A 1 133 GLU 133 113 113 GLU GLU A . n 
A 1 134 ALA 134 114 114 ALA ALA A . n 
A 1 135 ALA 135 115 115 ALA ALA A . n 
A 1 136 LYS 136 116 116 LYS LYS A . n 
A 1 137 ALA 137 117 117 ALA ALA A . n 
A 1 138 LYS 138 118 118 LYS LYS A . n 
A 1 139 VAL 139 119 119 VAL VAL A . n 
A 1 140 ALA 140 120 120 ALA ALA A . n 
A 1 141 THR 141 121 121 THR THR A . n 
A 1 142 PHE 142 122 122 PHE PHE A . n 
A 1 143 MET 143 123 123 MET MET A . n 
A 1 144 ARG 144 124 124 ARG ARG A . n 
A 1 145 TRP 145 125 125 TRP TRP A . n 
A 1 146 CYS 146 126 126 CYS CYS A . n 
A 1 147 THR 147 127 127 THR THR A . n 
A 1 148 GLY 148 128 128 GLY GLY A . n 
A 1 149 ASP 149 129 129 ASP ASP A . n 
A 1 150 SER 150 130 130 SER SER A . n 
A 1 151 LEU 151 131 131 LEU LEU A . n 
A 1 152 ALA 152 132 132 ALA ALA A . n 
A 1 153 ALA 153 133 133 ALA ALA A . n 
A 1 154 GLY 154 134 134 GLY GLY A . n 
A 1 155 VAL 155 135 135 VAL VAL A . n 
A 1 156 ALA 156 136 136 ALA ALA A . n 
A 1 157 ALA 157 137 137 ALA ALA A . n 
A 1 158 LEU 158 138 138 LEU LEU A . n 
A 1 159 TYR 159 139 139 TYR TYR A . n 
A 1 160 SER 160 140 140 SER SER A . n 
A 1 161 TYR 161 141 141 TYR TYR A . n 
A 1 162 GLU 162 142 142 GLU GLU A . n 
A 1 163 SER 163 143 143 SER SER A . n 
A 1 164 GLN 164 144 144 GLN GLN A . n 
A 1 165 ILE 165 145 145 ILE ILE A . n 
A 1 166 PRO 166 146 146 PRO PRO A . n 
A 1 167 ARG 167 147 147 ARG ARG A . n 
A 1 168 ILE 168 148 148 ILE ILE A . n 
A 1 169 ALA 169 149 149 ALA ALA A . n 
A 1 170 ARG 170 150 150 ARG ARG A . n 
A 1 171 GLU 171 151 151 GLU GLU A . n 
A 1 172 LYS 172 152 152 LYS LYS A . n 
A 1 173 ILE 173 153 153 ILE ILE A . n 
A 1 174 ARG 174 154 154 ARG ARG A . n 
A 1 175 GLY 175 155 155 GLY GLY A . n 
A 1 176 LEU 176 156 156 LEU LEU A . n 
A 1 177 THR 177 157 157 THR THR A . n 
A 1 178 GLU 178 158 158 GLU GLU A . n 
A 1 179 TYR 179 159 159 TYR TYR A . n 
A 1 180 PHE 180 160 160 PHE PHE A . n 
A 1 181 GLY 181 161 161 GLY GLY A . n 
A 1 182 PHE 182 162 162 PHE PHE A . n 
A 1 183 SER 183 163 163 SER SER A . n 
A 1 184 ASN 184 164 164 ASN ASN A . n 
A 1 185 PRO 185 165 165 PRO PRO A . n 
A 1 186 GLU 186 166 166 GLU GLU A . n 
A 1 187 ASP 187 167 167 ASP ASP A . n 
A 1 188 TYR 188 168 168 TYR TYR A . n 
A 1 189 ALA 189 169 169 ALA ALA A . n 
A 1 190 TYR 190 170 170 TYR TYR A . n 
A 1 191 PHE 191 171 171 PHE PHE A . n 
A 1 192 THR 192 172 172 THR THR A . n 
A 1 193 GLU 193 173 173 GLU GLU A . n 
A 1 194 HIS 194 174 174 HIS HIS A . n 
A 1 195 GLU 195 175 175 GLU GLU A . n 
A 1 196 GLU 196 176 176 GLU GLU A . n 
A 1 197 ALA 197 177 177 ALA ALA A . n 
A 1 198 ASP 198 178 178 ASP ASP A . n 
A 1 199 VAL 199 179 179 VAL VAL A . n 
A 1 200 ARG 200 180 180 ARG ARG A . n 
A 1 201 HIS 201 181 181 HIS HIS A . n 
A 1 202 ALA 202 182 182 ALA ALA A . n 
A 1 203 ARG 203 183 183 ARG ARG A . n 
A 1 204 GLU 204 184 184 GLU GLU A . n 
A 1 205 GLU 205 185 185 GLU GLU A . n 
A 1 206 LYS 206 186 186 LYS LYS A . n 
A 1 207 ALA 207 187 187 ALA ALA A . n 
A 1 208 LEU 208 188 188 LEU LEU A . n 
A 1 209 ILE 209 189 189 ILE ILE A . n 
A 1 210 GLU 210 190 190 GLU GLU A . n 
A 1 211 MET 211 191 191 MET MET A . n 
A 1 212 LEU 212 192 192 LEU LEU A . n 
A 1 213 LEU 213 193 193 LEU LEU A . n 
A 1 214 LYS 214 194 194 LYS LYS A . n 
A 1 215 ASP 215 195 195 ASP ASP A . n 
A 1 216 ASP 216 196 196 ASP ASP A . n 
A 1 217 ALA 217 197 197 ALA ALA A . n 
A 1 218 ASP 218 198 198 ASP ASP A . n 
A 1 219 LYS 219 199 199 LYS LYS A . n 
A 1 220 VAL 220 200 200 VAL VAL A . n 
A 1 221 LEU 221 201 201 LEU LEU A . n 
A 1 222 GLU 222 202 202 GLU GLU A . n 
A 1 223 ALA 223 203 203 ALA ALA A . n 
A 1 224 SER 224 204 204 SER SER A . n 
A 1 225 GLN 225 205 205 GLN GLN A . n 
A 1 226 GLU 226 206 206 GLU GLU A . n 
A 1 227 VAL 227 207 207 VAL VAL A . n 
A 1 228 THR 228 208 208 THR THR A . n 
A 1 229 GLN 229 209 209 GLN GLN A . n 
A 1 230 SER 230 210 210 SER SER A . n 
A 1 231 LEU 231 211 211 LEU LEU A . n 
A 1 232 TYR 232 212 212 TYR TYR A . n 
A 1 233 GLY 233 213 213 GLY GLY A . n 
A 1 234 PHE 234 214 214 PHE PHE A . n 
A 1 235 LEU 235 215 215 LEU LEU A . n 
A 1 236 ASP 236 216 216 ASP ASP A . n 
A 1 237 SER 237 217 217 SER SER A . n 
A 1 238 PHE 238 218 218 PHE PHE A . n 
A 1 239 LEU 239 219 219 LEU LEU A . n 
A 1 240 ASP 240 220 ?   ?   ?   A . n 
B 1 1   MET 1   -19 ?   ?   ?   B . n 
B 1 2   GLY 2   -18 ?   ?   ?   B . n 
B 1 3   SER 3   -17 ?   ?   ?   B . n 
B 1 4   SER 4   -16 ?   ?   ?   B . n 
B 1 5   HIS 5   -15 ?   ?   ?   B . n 
B 1 6   HIS 6   -14 ?   ?   ?   B . n 
B 1 7   HIS 7   -13 ?   ?   ?   B . n 
B 1 8   HIS 8   -12 ?   ?   ?   B . n 
B 1 9   HIS 9   -11 ?   ?   ?   B . n 
B 1 10  HIS 10  -10 ?   ?   ?   B . n 
B 1 11  SER 11  -9  ?   ?   ?   B . n 
B 1 12  SER 12  -8  ?   ?   ?   B . n 
B 1 13  GLY 13  -7  ?   ?   ?   B . n 
B 1 14  LEU 14  -6  ?   ?   ?   B . n 
B 1 15  VAL 15  -5  ?   ?   ?   B . n 
B 1 16  PRO 16  -4  ?   ?   ?   B . n 
B 1 17  ARG 17  -3  ?   ?   ?   B . n 
B 1 18  GLY 18  -2  ?   ?   ?   B . n 
B 1 19  SER 19  -1  ?   ?   ?   B . n 
B 1 20  HIS 20  0   ?   ?   ?   B . n 
B 1 21  MET 21  1   ?   ?   ?   B . n 
B 1 22  MET 22  2   ?   ?   ?   B . n 
B 1 23  GLU 23  3   ?   ?   ?   B . n 
B 1 24  VAL 24  4   ?   ?   ?   B . n 
B 1 25  PHE 25  5   ?   ?   ?   B . n 
B 1 26  MET 26  6   6   MET MET B . n 
B 1 27  ASN 27  7   7   ASN ASN B . n 
B 1 28  PHE 28  8   8   PHE PHE B . n 
B 1 29  LEU 29  9   9   LEU LEU B . n 
B 1 30  ASP 30  10  10  ASP ASP B . n 
B 1 31  GLN 31  11  11  GLN GLN B . n 
B 1 32  LEU 32  12  12  LEU LEU B . n 
B 1 33  ASP 33  13  13  ASP ASP B . n 
B 1 34  LEU 34  14  14  LEU LEU B . n 
B 1 35  ILE 35  15  15  ILE ILE B . n 
B 1 36  ILE 36  16  16  ILE ILE B . n 
B 1 37  GLN 37  17  17  GLN GLN B . n 
B 1 38  ASN 38  18  18  ASN ASN B . n 
B 1 39  LYS 39  19  19  LYS LYS B . n 
B 1 40  HIS 40  20  20  HIS HIS B . n 
B 1 41  MET 41  21  21  MET MET B . n 
B 1 42  LEU 42  22  22  LEU LEU B . n 
B 1 43  GLU 43  23  23  GLU GLU B . n 
B 1 44  HIS 44  24  24  HIS HIS B . n 
B 1 45  THR 45  25  25  THR THR B . n 
B 1 46  PHE 46  26  26  PHE PHE B . n 
B 1 47  TYR 47  27  27  TYR TYR B . n 
B 1 48  VAL 48  28  28  VAL VAL B . n 
B 1 49  LYS 49  29  29  LYS LYS B . n 
B 1 50  TRP 50  30  30  TRP TRP B . n 
B 1 51  SER 51  31  31  SER SER B . n 
B 1 52  LYS 52  32  32  LYS LYS B . n 
B 1 53  GLY 53  33  33  GLY GLY B . n 
B 1 54  GLU 54  34  34  GLU GLU B . n 
B 1 55  LEU 55  35  35  LEU LEU B . n 
B 1 56  THR 56  36  36  THR THR B . n 
B 1 57  LYS 57  37  37  LYS LYS B . n 
B 1 58  GLU 58  38  38  GLU GLU B . n 
B 1 59  GLN 59  39  39  GLN GLN B . n 
B 1 60  LEU 60  40  40  LEU LEU B . n 
B 1 61  GLN 61  41  41  GLN GLN B . n 
B 1 62  ALA 62  42  42  ALA ALA B . n 
B 1 63  TYR 63  43  43  TYR TYR B . n 
B 1 64  ALA 64  44  44  ALA ALA B . n 
B 1 65  LYS 65  45  45  LYS LYS B . n 
B 1 66  ASP 66  46  46  ASP ASP B . n 
B 1 67  TYR 67  47  47  TYR TYR B . n 
B 1 68  TYR 68  48  48  TYR TYR B . n 
B 1 69  LEU 69  49  49  LEU LEU B . n 
B 1 70  HIS 70  50  50  HIS HIS B . n 
B 1 71  ILE 71  51  51  ILE ILE B . n 
B 1 72  LYS 72  52  52  LYS LYS B . n 
B 1 73  ALA 73  53  53  ALA ALA B . n 
B 1 74  PHE 74  54  54  PHE PHE B . n 
B 1 75  PRO 75  55  55  PRO PRO B . n 
B 1 76  LYS 76  56  56  LYS LYS B . n 
B 1 77  TYR 77  57  57  TYR TYR B . n 
B 1 78  LEU 78  58  58  LEU LEU B . n 
B 1 79  SER 79  59  59  SER SER B . n 
B 1 80  ALA 80  60  60  ALA ALA B . n 
B 1 81  ILE 81  61  61  ILE ILE B . n 
B 1 82  HIS 82  62  62  HIS HIS B . n 
B 1 83  SER 83  63  63  SER SER B . n 
B 1 84  ARG 84  64  64  ARG ARG B . n 
B 1 85  CYS 85  65  65  CYS CYS B . n 
B 1 86  ASP 86  66  66  ASP ASP B . n 
B 1 87  ASP 87  67  67  ASP ASP B . n 
B 1 88  LEU 88  68  68  LEU LEU B . n 
B 1 89  GLU 89  69  69  GLU GLU B . n 
B 1 90  ALA 90  70  70  ALA ALA B . n 
B 1 91  ARG 91  71  71  ARG ARG B . n 
B 1 92  LYS 92  72  72  LYS LYS B . n 
B 1 93  LEU 93  73  73  LEU LEU B . n 
B 1 94  LEU 94  74  74  LEU LEU B . n 
B 1 95  LEU 95  75  75  LEU LEU B . n 
B 1 96  ASP 96  76  76  ASP ASP B . n 
B 1 97  ASN 97  77  77  ASN ASN B . n 
B 1 98  LEU 98  78  78  LEU LEU B . n 
B 1 99  MET 99  79  79  MET MET B . n 
B 1 100 ASP 100 80  80  ASP ASP B . n 
B 1 101 GLU 101 81  81  GLU GLU B . n 
B 1 102 GLU 102 82  82  GLU GLU B . n 
B 1 103 ASN 103 83  83  ASN ASN B . n 
B 1 104 GLY 104 84  84  GLY GLY B . n 
B 1 105 TYR 105 85  85  TYR TYR B . n 
B 1 106 PRO 106 86  86  PRO PRO B . n 
B 1 107 ASN 107 87  87  ASN ASN B . n 
B 1 108 HIS 108 88  88  HIS HIS B . n 
B 1 109 ILE 109 89  89  ILE ILE B . n 
B 1 110 ASP 110 90  90  ASP ASP B . n 
B 1 111 LEU 111 91  91  LEU LEU B . n 
B 1 112 TRP 112 92  92  TRP TRP B . n 
B 1 113 LYS 113 93  93  LYS LYS B . n 
B 1 114 GLN 114 94  94  GLN GLN B . n 
B 1 115 PHE 115 95  95  PHE PHE B . n 
B 1 116 VAL 116 96  96  VAL VAL B . n 
B 1 117 PHE 117 97  97  PHE PHE B . n 
B 1 118 ALA 118 98  98  ALA ALA B . n 
B 1 119 LEU 119 99  99  LEU LEU B . n 
B 1 120 GLY 120 100 100 GLY GLY B . n 
B 1 121 VAL 121 101 101 VAL VAL B . n 
B 1 122 THR 122 102 102 THR THR B . n 
B 1 123 PRO 123 103 103 PRO PRO B . n 
B 1 124 GLU 124 104 104 GLU GLU B . n 
B 1 125 GLU 125 105 105 GLU GLU B . n 
B 1 126 LEU 126 106 106 LEU LEU B . n 
B 1 127 GLU 127 107 107 GLU GLU B . n 
B 1 128 ALA 128 108 108 ALA ALA B . n 
B 1 129 HIS 129 109 109 HIS HIS B . n 
B 1 130 GLU 130 110 110 GLU GLU B . n 
B 1 131 PRO 131 111 111 PRO PRO B . n 
B 1 132 SER 132 112 112 SER SER B . n 
B 1 133 GLU 133 113 113 GLU GLU B . n 
B 1 134 ALA 134 114 114 ALA ALA B . n 
B 1 135 ALA 135 115 115 ALA ALA B . n 
B 1 136 LYS 136 116 116 LYS LYS B . n 
B 1 137 ALA 137 117 117 ALA ALA B . n 
B 1 138 LYS 138 118 118 LYS LYS B . n 
B 1 139 VAL 139 119 119 VAL VAL B . n 
B 1 140 ALA 140 120 120 ALA ALA B . n 
B 1 141 THR 141 121 121 THR THR B . n 
B 1 142 PHE 142 122 122 PHE PHE B . n 
B 1 143 MET 143 123 123 MET MET B . n 
B 1 144 ARG 144 124 124 ARG ARG B . n 
B 1 145 TRP 145 125 125 TRP TRP B . n 
B 1 146 CYS 146 126 126 CYS CYS B . n 
B 1 147 THR 147 127 127 THR THR B . n 
B 1 148 GLY 148 128 128 GLY GLY B . n 
B 1 149 ASP 149 129 129 ASP ASP B . n 
B 1 150 SER 150 130 130 SER SER B . n 
B 1 151 LEU 151 131 131 LEU LEU B . n 
B 1 152 ALA 152 132 132 ALA ALA B . n 
B 1 153 ALA 153 133 133 ALA ALA B . n 
B 1 154 GLY 154 134 134 GLY GLY B . n 
B 1 155 VAL 155 135 135 VAL VAL B . n 
B 1 156 ALA 156 136 136 ALA ALA B . n 
B 1 157 ALA 157 137 137 ALA ALA B . n 
B 1 158 LEU 158 138 138 LEU LEU B . n 
B 1 159 TYR 159 139 139 TYR TYR B . n 
B 1 160 SER 160 140 140 SER SER B . n 
B 1 161 TYR 161 141 141 TYR TYR B . n 
B 1 162 GLU 162 142 142 GLU GLU B . n 
B 1 163 SER 163 143 143 SER SER B . n 
B 1 164 GLN 164 144 144 GLN GLN B . n 
B 1 165 ILE 165 145 145 ILE ILE B . n 
B 1 166 PRO 166 146 146 PRO PRO B . n 
B 1 167 ARG 167 147 147 ARG ARG B . n 
B 1 168 ILE 168 148 148 ILE ILE B . n 
B 1 169 ALA 169 149 149 ALA ALA B . n 
B 1 170 ARG 170 150 150 ARG ARG B . n 
B 1 171 GLU 171 151 151 GLU GLU B . n 
B 1 172 LYS 172 152 152 LYS LYS B . n 
B 1 173 ILE 173 153 153 ILE ILE B . n 
B 1 174 ARG 174 154 154 ARG ARG B . n 
B 1 175 GLY 175 155 155 GLY GLY B . n 
B 1 176 LEU 176 156 156 LEU LEU B . n 
B 1 177 THR 177 157 157 THR THR B . n 
B 1 178 GLU 178 158 158 GLU GLU B . n 
B 1 179 TYR 179 159 159 TYR TYR B . n 
B 1 180 PHE 180 160 160 PHE PHE B . n 
B 1 181 GLY 181 161 161 GLY GLY B . n 
B 1 182 PHE 182 162 162 PHE PHE B . n 
B 1 183 SER 183 163 163 SER SER B . n 
B 1 184 ASN 184 164 164 ASN ASN B . n 
B 1 185 PRO 185 165 165 PRO PRO B . n 
B 1 186 GLU 186 166 166 GLU GLU B . n 
B 1 187 ASP 187 167 167 ASP ASP B . n 
B 1 188 TYR 188 168 168 TYR TYR B . n 
B 1 189 ALA 189 169 169 ALA ALA B . n 
B 1 190 TYR 190 170 170 TYR TYR B . n 
B 1 191 PHE 191 171 171 PHE PHE B . n 
B 1 192 THR 192 172 172 THR THR B . n 
B 1 193 GLU 193 173 173 GLU GLU B . n 
B 1 194 HIS 194 174 174 HIS HIS B . n 
B 1 195 GLU 195 175 175 GLU GLU B . n 
B 1 196 GLU 196 176 176 GLU GLU B . n 
B 1 197 ALA 197 177 177 ALA ALA B . n 
B 1 198 ASP 198 178 178 ASP ASP B . n 
B 1 199 VAL 199 179 179 VAL VAL B . n 
B 1 200 ARG 200 180 180 ARG ARG B . n 
B 1 201 HIS 201 181 181 HIS HIS B . n 
B 1 202 ALA 202 182 182 ALA ALA B . n 
B 1 203 ARG 203 183 183 ARG ARG B . n 
B 1 204 GLU 204 184 184 GLU GLU B . n 
B 1 205 GLU 205 185 185 GLU GLU B . n 
B 1 206 LYS 206 186 186 LYS LYS B . n 
B 1 207 ALA 207 187 187 ALA ALA B . n 
B 1 208 LEU 208 188 188 LEU LEU B . n 
B 1 209 ILE 209 189 189 ILE ILE B . n 
B 1 210 GLU 210 190 190 GLU GLU B . n 
B 1 211 MET 211 191 191 MET MET B . n 
B 1 212 LEU 212 192 192 LEU LEU B . n 
B 1 213 LEU 213 193 193 LEU LEU B . n 
B 1 214 LYS 214 194 194 LYS LYS B . n 
B 1 215 ASP 215 195 195 ASP ASP B . n 
B 1 216 ASP 216 196 196 ASP ASP B . n 
B 1 217 ALA 217 197 197 ALA ALA B . n 
B 1 218 ASP 218 198 198 ASP ASP B . n 
B 1 219 LYS 219 199 199 LYS LYS B . n 
B 1 220 VAL 220 200 200 VAL VAL B . n 
B 1 221 LEU 221 201 201 LEU LEU B . n 
B 1 222 GLU 222 202 202 GLU GLU B . n 
B 1 223 ALA 223 203 203 ALA ALA B . n 
B 1 224 SER 224 204 204 SER SER B . n 
B 1 225 GLN 225 205 205 GLN GLN B . n 
B 1 226 GLU 226 206 206 GLU GLU B . n 
B 1 227 VAL 227 207 207 VAL VAL B . n 
B 1 228 THR 228 208 208 THR THR B . n 
B 1 229 GLN 229 209 209 GLN GLN B . n 
B 1 230 SER 230 210 210 SER SER B . n 
B 1 231 LEU 231 211 211 LEU LEU B . n 
B 1 232 TYR 232 212 212 TYR TYR B . n 
B 1 233 GLY 233 213 213 GLY GLY B . n 
B 1 234 PHE 234 214 214 PHE PHE B . n 
B 1 235 LEU 235 215 215 LEU LEU B . n 
B 1 236 ASP 236 216 216 ASP ASP B . n 
B 1 237 SER 237 217 217 SER SER B . n 
B 1 238 PHE 238 218 218 PHE PHE B . n 
B 1 239 LEU 239 219 219 LEU LEU B . n 
B 1 240 ASP 240 220 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 FE2 ? ? FE2 ? ? 'SUBJECT OF INVESTIGATION' ? 
2 GOL ? ? GOL ? ? 'SUBJECT OF INVESTIGATION' ? 
3 MN  ? ? MN  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 FE2 1  301 1   FE2 FE2 A . 
D 3 MN  1  302 2   MN  MN  A . 
E 4 GOL 1  301 301 GOL GOL B . 
F 2 FE2 1  302 3   FE2 FE2 B . 
G 3 MN  1  303 4   MN  MN  B . 
H 5 HOH 1  401 32  HOH HOH A . 
H 5 HOH 2  402 28  HOH HOH A . 
H 5 HOH 3  403 35  HOH HOH A . 
H 5 HOH 4  404 14  HOH HOH A . 
H 5 HOH 5  405 41  HOH HOH A . 
H 5 HOH 6  406 40  HOH HOH A . 
H 5 HOH 7  407 6   HOH HOH A . 
H 5 HOH 8  408 42  HOH HOH A . 
H 5 HOH 9  409 55  HOH HOH A . 
H 5 HOH 10 410 62  HOH HOH A . 
H 5 HOH 11 411 5   HOH HOH A . 
H 5 HOH 12 412 7   HOH HOH A . 
H 5 HOH 13 413 16  HOH HOH A . 
H 5 HOH 14 414 24  HOH HOH A . 
H 5 HOH 15 415 10  HOH HOH A . 
H 5 HOH 16 416 2   HOH HOH A . 
H 5 HOH 17 417 33  HOH HOH A . 
H 5 HOH 18 418 9   HOH HOH A . 
H 5 HOH 19 419 39  HOH HOH A . 
H 5 HOH 20 420 13  HOH HOH A . 
H 5 HOH 21 421 58  HOH HOH A . 
H 5 HOH 22 422 15  HOH HOH A . 
H 5 HOH 23 423 17  HOH HOH A . 
H 5 HOH 24 424 1   HOH HOH A . 
H 5 HOH 25 425 31  HOH HOH A . 
H 5 HOH 26 426 36  HOH HOH A . 
H 5 HOH 27 427 38  HOH HOH A . 
H 5 HOH 28 428 65  HOH HOH A . 
H 5 HOH 29 429 8   HOH HOH A . 
H 5 HOH 30 430 47  HOH HOH A . 
I 5 HOH 1  401 46  HOH HOH B . 
I 5 HOH 2  402 49  HOH HOH B . 
I 5 HOH 3  403 30  HOH HOH B . 
I 5 HOH 4  404 51  HOH HOH B . 
I 5 HOH 5  405 61  HOH HOH B . 
I 5 HOH 6  406 21  HOH HOH B . 
I 5 HOH 7  407 4   HOH HOH B . 
I 5 HOH 8  408 20  HOH HOH B . 
I 5 HOH 9  409 11  HOH HOH B . 
I 5 HOH 10 410 12  HOH HOH B . 
I 5 HOH 11 411 37  HOH HOH B . 
I 5 HOH 12 412 27  HOH HOH B . 
I 5 HOH 13 413 26  HOH HOH B . 
I 5 HOH 14 414 54  HOH HOH B . 
I 5 HOH 15 415 60  HOH HOH B . 
I 5 HOH 16 416 59  HOH HOH B . 
I 5 HOH 17 417 34  HOH HOH B . 
I 5 HOH 18 418 63  HOH HOH B . 
I 5 HOH 19 419 3   HOH HOH B . 
I 5 HOH 20 420 23  HOH HOH B . 
I 5 HOH 21 421 44  HOH HOH B . 
I 5 HOH 22 422 19  HOH HOH B . 
I 5 HOH 23 423 25  HOH HOH B . 
I 5 HOH 24 424 18  HOH HOH B . 
I 5 HOH 25 425 48  HOH HOH B . 
I 5 HOH 26 426 43  HOH HOH B . 
I 5 HOH 27 427 22  HOH HOH B . 
I 5 HOH 28 428 57  HOH HOH B . 
I 5 HOH 29 429 45  HOH HOH B . 
I 5 HOH 30 430 50  HOH HOH B . 
I 5 HOH 31 431 52  HOH HOH B . 
I 5 HOH 32 432 56  HOH HOH B . 
I 5 HOH 33 433 64  HOH HOH B . 
I 5 HOH 34 434 29  HOH HOH B . 
I 5 HOH 35 435 53  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A MET 6   ? N   ? A MET 26  N   
2   1 Y 1 A MET 6   ? CB  ? A MET 26  CB  
3   1 Y 1 A MET 6   ? CG  ? A MET 26  CG  
4   1 Y 1 A MET 6   ? SD  ? A MET 26  SD  
5   1 Y 1 A MET 6   ? CE  ? A MET 26  CE  
6   1 Y 1 A GLN 11  ? CD  ? A GLN 31  CD  
7   1 Y 1 A GLN 11  ? OE1 ? A GLN 31  OE1 
8   1 Y 1 A GLN 11  ? NE2 ? A GLN 31  NE2 
9   1 Y 1 A VAL 28  ? CG1 ? A VAL 48  CG1 
10  1 Y 1 A VAL 28  ? CG2 ? A VAL 48  CG2 
11  1 Y 1 A LYS 29  ? NZ  ? A LYS 49  NZ  
12  1 Y 1 A SER 31  ? OG  ? A SER 51  OG  
13  1 Y 1 A LYS 32  ? CG  ? A LYS 52  CG  
14  1 Y 1 A LYS 32  ? CD  ? A LYS 52  CD  
15  1 Y 1 A LYS 32  ? CE  ? A LYS 52  CE  
16  1 Y 1 A LYS 32  ? NZ  ? A LYS 52  NZ  
17  1 Y 1 A GLU 34  ? CB  ? A GLU 54  CB  
18  1 Y 1 A GLU 34  ? CG  ? A GLU 54  CG  
19  1 Y 1 A GLU 34  ? CD  ? A GLU 54  CD  
20  1 Y 1 A GLU 34  ? OE1 ? A GLU 54  OE1 
21  1 Y 1 A GLU 34  ? OE2 ? A GLU 54  OE2 
22  1 Y 1 A LEU 35  ? CD1 ? A LEU 55  CD1 
23  1 Y 1 A LEU 35  ? CD2 ? A LEU 55  CD2 
24  1 Y 1 A THR 36  ? OG1 ? A THR 56  OG1 
25  1 Y 1 A LYS 37  ? CG  ? A LYS 57  CG  
26  1 Y 1 A LYS 37  ? CD  ? A LYS 57  CD  
27  1 Y 1 A LYS 37  ? CE  ? A LYS 57  CE  
28  1 Y 1 A LYS 37  ? NZ  ? A LYS 57  NZ  
29  1 Y 1 A GLU 38  ? CG  ? A GLU 58  CG  
30  1 Y 1 A GLU 38  ? CD  ? A GLU 58  CD  
31  1 Y 1 A GLU 38  ? OE1 ? A GLU 58  OE1 
32  1 Y 1 A GLU 38  ? OE2 ? A GLU 58  OE2 
33  1 Y 1 A LEU 40  ? CD1 ? A LEU 60  CD1 
34  1 Y 1 A LEU 40  ? CD2 ? A LEU 60  CD2 
35  1 Y 1 A LYS 45  ? NZ  ? A LYS 65  NZ  
36  1 Y 1 A LEU 49  ? CD2 ? A LEU 69  CD2 
37  1 Y 1 A LYS 52  ? NZ  ? A LYS 72  NZ  
38  1 Y 1 A LEU 68  ? CD1 ? A LEU 88  CD1 
39  1 Y 1 A LEU 68  ? CD2 ? A LEU 88  CD2 
40  1 Y 1 A LYS 72  ? CE  ? A LYS 92  CE  
41  1 Y 1 A LYS 72  ? NZ  ? A LYS 92  NZ  
42  1 Y 1 A ILE 89  ? CD1 ? A ILE 109 CD1 
43  1 Y 1 A VAL 96  ? CG1 ? A VAL 116 CG1 
44  1 Y 1 A LEU 99  ? CG  ? A LEU 119 CG  
45  1 Y 1 A LEU 99  ? CD1 ? A LEU 119 CD1 
46  1 Y 1 A LEU 99  ? CD2 ? A LEU 119 CD2 
47  1 Y 1 A THR 102 ? CG2 ? A THR 122 CG2 
48  1 Y 1 A GLU 104 ? CG  ? A GLU 124 CG  
49  1 Y 1 A GLU 104 ? CD  ? A GLU 124 CD  
50  1 Y 1 A GLU 104 ? OE1 ? A GLU 124 OE1 
51  1 Y 1 A GLU 104 ? OE2 ? A GLU 124 OE2 
52  1 Y 1 A ALA 108 ? CB  ? A ALA 128 CB  
53  1 Y 1 A ALA 114 ? CB  ? A ALA 134 CB  
54  1 Y 1 A ARG 147 ? CD  ? A ARG 167 CD  
55  1 Y 1 A ARG 147 ? NE  ? A ARG 167 NE  
56  1 Y 1 A ARG 147 ? CZ  ? A ARG 167 CZ  
57  1 Y 1 A ARG 147 ? NH1 ? A ARG 167 NH1 
58  1 Y 1 A ARG 147 ? NH2 ? A ARG 167 NH2 
59  1 Y 1 A ILE 148 ? CG2 ? A ILE 168 CG2 
60  1 Y 1 A ILE 148 ? CD1 ? A ILE 168 CD1 
61  1 Y 1 A LYS 152 ? CG  ? A LYS 172 CG  
62  1 Y 1 A LYS 152 ? CD  ? A LYS 172 CD  
63  1 Y 1 A LYS 152 ? CE  ? A LYS 172 CE  
64  1 Y 1 A LYS 152 ? NZ  ? A LYS 172 NZ  
65  1 Y 1 A GLU 158 ? CG  ? A GLU 178 CG  
66  1 Y 1 A GLU 158 ? CD  ? A GLU 178 CD  
67  1 Y 1 A GLU 158 ? OE1 ? A GLU 178 OE1 
68  1 Y 1 A GLU 158 ? OE2 ? A GLU 178 OE2 
69  1 Y 1 A SER 163 ? OG  ? A SER 183 OG  
70  1 Y 1 A GLU 166 ? CG  ? A GLU 186 CG  
71  1 Y 1 A GLU 166 ? CD  ? A GLU 186 CD  
72  1 Y 1 A GLU 166 ? OE1 ? A GLU 186 OE1 
73  1 Y 1 A GLU 166 ? OE2 ? A GLU 186 OE2 
74  1 Y 1 A GLU 175 ? CB  ? A GLU 195 CB  
75  1 Y 1 A GLU 175 ? CG  ? A GLU 195 CG  
76  1 Y 1 A GLU 175 ? CD  ? A GLU 195 CD  
77  1 Y 1 A GLU 175 ? OE1 ? A GLU 195 OE1 
78  1 Y 1 A GLU 175 ? OE2 ? A GLU 195 OE2 
79  1 Y 1 A GLU 176 ? CD  ? A GLU 196 CD  
80  1 Y 1 A GLU 176 ? OE1 ? A GLU 196 OE1 
81  1 Y 1 A GLU 176 ? OE2 ? A GLU 196 OE2 
82  1 Y 1 A LYS 194 ? CD  ? A LYS 214 CD  
83  1 Y 1 A LYS 194 ? CE  ? A LYS 214 CE  
84  1 Y 1 A LYS 194 ? NZ  ? A LYS 214 NZ  
85  1 Y 1 A LYS 199 ? CE  ? A LYS 219 CE  
86  1 Y 1 A LYS 199 ? NZ  ? A LYS 219 NZ  
87  1 Y 1 A LEU 201 ? CD2 ? A LEU 221 CD2 
88  1 Y 1 A SER 210 ? OG  ? A SER 230 OG  
89  1 Y 1 A LEU 219 ? O   ? A LEU 239 O   
90  1 Y 1 A LEU 219 ? CD1 ? A LEU 239 CD1 
91  1 Y 1 A LEU 219 ? CD2 ? A LEU 239 CD2 
92  1 Y 1 B MET 6   ? CB  ? B MET 26  CB  
93  1 Y 1 B MET 6   ? CG  ? B MET 26  CG  
94  1 Y 1 B MET 6   ? SD  ? B MET 26  SD  
95  1 Y 1 B MET 6   ? CE  ? B MET 26  CE  
96  1 Y 1 B GLN 11  ? CG  ? B GLN 31  CG  
97  1 Y 1 B GLN 11  ? CD  ? B GLN 31  CD  
98  1 Y 1 B GLN 11  ? OE1 ? B GLN 31  OE1 
99  1 Y 1 B GLN 11  ? NE2 ? B GLN 31  NE2 
100 1 Y 1 B LYS 19  ? CE  ? B LYS 39  CE  
101 1 Y 1 B LYS 19  ? NZ  ? B LYS 39  NZ  
102 1 Y 1 B LEU 22  ? CD1 ? B LEU 42  CD1 
103 1 Y 1 B LEU 22  ? CD2 ? B LEU 42  CD2 
104 1 Y 1 B VAL 28  ? CG1 ? B VAL 48  CG1 
105 1 Y 1 B VAL 28  ? CG2 ? B VAL 48  CG2 
106 1 Y 1 B LYS 29  ? CD  ? B LYS 49  CD  
107 1 Y 1 B LYS 29  ? CE  ? B LYS 49  CE  
108 1 Y 1 B LYS 29  ? NZ  ? B LYS 49  NZ  
109 1 Y 1 B SER 31  ? OG  ? B SER 51  OG  
110 1 Y 1 B LYS 32  ? CG  ? B LYS 52  CG  
111 1 Y 1 B LYS 32  ? CD  ? B LYS 52  CD  
112 1 Y 1 B LYS 32  ? CE  ? B LYS 52  CE  
113 1 Y 1 B LYS 32  ? NZ  ? B LYS 52  NZ  
114 1 Y 1 B GLU 34  ? CD  ? B GLU 54  CD  
115 1 Y 1 B GLU 34  ? OE1 ? B GLU 54  OE1 
116 1 Y 1 B GLU 34  ? OE2 ? B GLU 54  OE2 
117 1 Y 1 B LEU 35  ? CD1 ? B LEU 55  CD1 
118 1 Y 1 B LEU 35  ? CD2 ? B LEU 55  CD2 
119 1 Y 1 B LYS 37  ? CG  ? B LYS 57  CG  
120 1 Y 1 B LYS 37  ? CD  ? B LYS 57  CD  
121 1 Y 1 B LYS 37  ? CE  ? B LYS 57  CE  
122 1 Y 1 B LYS 37  ? NZ  ? B LYS 57  NZ  
123 1 Y 1 B LEU 40  ? CG  ? B LEU 60  CG  
124 1 Y 1 B LEU 40  ? CD1 ? B LEU 60  CD1 
125 1 Y 1 B LEU 40  ? CD2 ? B LEU 60  CD2 
126 1 Y 1 B LYS 45  ? CE  ? B LYS 65  CE  
127 1 Y 1 B LYS 45  ? NZ  ? B LYS 65  NZ  
128 1 Y 1 B SER 59  ? OG  ? B SER 79  OG  
129 1 Y 1 B LEU 99  ? CD1 ? B LEU 119 CD1 
130 1 Y 1 B LEU 99  ? CD2 ? B LEU 119 CD2 
131 1 Y 1 B LEU 106 ? CD1 ? B LEU 126 CD1 
132 1 Y 1 B LEU 106 ? CD2 ? B LEU 126 CD2 
133 1 Y 1 B GLU 110 ? OE1 ? B GLU 130 OE1 
134 1 Y 1 B GLU 110 ? OE2 ? B GLU 130 OE2 
135 1 Y 1 B ILE 145 ? CD1 ? B ILE 165 CD1 
136 1 Y 1 B ILE 148 ? CD1 ? B ILE 168 CD1 
137 1 Y 1 B LYS 152 ? CE  ? B LYS 172 CE  
138 1 Y 1 B LYS 152 ? NZ  ? B LYS 172 NZ  
139 1 Y 1 B ILE 153 ? CD1 ? B ILE 173 CD1 
140 1 Y 1 B ARG 154 ? CD  ? B ARG 174 CD  
141 1 Y 1 B ARG 154 ? NE  ? B ARG 174 NE  
142 1 Y 1 B ARG 154 ? CZ  ? B ARG 174 CZ  
143 1 Y 1 B ARG 154 ? NH1 ? B ARG 174 NH1 
144 1 Y 1 B ARG 154 ? NH2 ? B ARG 174 NH2 
145 1 Y 1 B LEU 156 ? CD1 ? B LEU 176 CD1 
146 1 Y 1 B LEU 156 ? CD2 ? B LEU 176 CD2 
147 1 Y 1 B GLU 158 ? CD  ? B GLU 178 CD  
148 1 Y 1 B GLU 158 ? OE1 ? B GLU 178 OE1 
149 1 Y 1 B GLU 158 ? OE2 ? B GLU 178 OE2 
150 1 Y 1 B GLU 166 ? OE1 ? B GLU 186 OE1 
151 1 Y 1 B GLU 166 ? OE2 ? B GLU 186 OE2 
152 1 Y 1 B GLU 176 ? CG  ? B GLU 196 CG  
153 1 Y 1 B GLU 176 ? CD  ? B GLU 196 CD  
154 1 Y 1 B GLU 176 ? OE1 ? B GLU 196 OE1 
155 1 Y 1 B GLU 176 ? OE2 ? B GLU 196 OE2 
156 1 Y 1 B ALA 177 ? CB  ? B ALA 197 CB  
157 1 Y 1 B ALA 182 ? CB  ? B ALA 202 CB  
158 1 Y 1 B LYS 194 ? CD  ? B LYS 214 CD  
159 1 Y 1 B LYS 194 ? CE  ? B LYS 214 CE  
160 1 Y 1 B LYS 194 ? NZ  ? B LYS 214 NZ  
161 1 Y 1 B LYS 199 ? CD  ? B LYS 219 CD  
162 1 Y 1 B LYS 199 ? CE  ? B LYS 219 CE  
163 1 Y 1 B LYS 199 ? NZ  ? B LYS 219 NZ  
164 1 Y 1 B SER 210 ? OG  ? B SER 230 OG  
165 1 Y 1 B LEU 215 ? CG  ? B LEU 235 CG  
166 1 Y 1 B LEU 215 ? CD1 ? B LEU 235 CD1 
167 1 Y 1 B LEU 215 ? CD2 ? B LEU 235 CD2 
168 1 Y 1 B LEU 219 ? CD1 ? B LEU 239 CD1 
169 1 Y 1 B LEU 219 ? CD2 ? B LEU 239 CD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? 1.12.15     3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8VA9 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     93.124 
_cell.length_a_esd                 ? 
_cell.length_b                     93.124 
_cell.length_b_esd                 ? 
_cell.length_c                     121.046 
_cell.length_c_esd                 ? 
_cell.volume                       909084.637 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8VA9 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            
;P 32 2"
;
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8VA9 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.73 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.91 
_exptl_crystal.description                  'Hexagonal plates' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.3 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M Lithium citrate tribasic tetrahydrate, 20% w/v PEG-3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    M 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
loop_
_diffrn_radiation_wavelength.id 
_diffrn_radiation_wavelength.wavelength 
_diffrn_radiation_wavelength.wt 
1 1.000 1.0 
2 1.729 1.0 
3 1.860 1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        '1.000, 1.729, 1.860' 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.2 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          60.64 
_reflns.entry_id                                       8VA9 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.35 
_reflns.d_resolution_low                               48.41 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25830 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.87 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.53 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.07961 
_reflns.pdbx_Rpim_I_all                                0.026 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.07512 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.35 
_reflns_shell.d_res_low                                     2.434 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.25 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             ? 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               9.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.8414 
_reflns_shell.pdbx_Rpim_I_all                               0.2652 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.97 
_reflns_shell.pdbx_CC_star                                  0.992 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.84 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.7978 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               70.10 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8VA9 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.35 
_refine.ls_d_res_low                             46.56 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25807 
_refine.ls_number_reflns_R_free                  1998 
_refine.ls_number_reflns_R_work                  23809 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.90 
_refine.ls_percent_reflns_R_free                 7.74 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2502 
_refine.ls_R_factor_R_free                       0.3074 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2455 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 41.6894 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.5444 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.35 
_refine_hist.d_res_low                        46.56 
_refine_hist.number_atoms_solvent             65 
_refine_hist.number_atoms_total               3408 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3333 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         10 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0088 ? 3432 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9112 ? 4652 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0471 ? 486  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0083 ? 613  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.7044 ? 468  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.35 2.41  . . 141 1665 99.78  . . . . 0.4207 . . . . . . . . . . . 0.5396 
'X-RAY DIFFRACTION' 2.41 2.47  . . 142 1685 100.00 . . . . 0.4142 . . . . . . . . . . . 0.5199 
'X-RAY DIFFRACTION' 2.47 2.55  . . 138 1667 99.89  . . . . 0.4187 . . . . . . . . . . . 0.4765 
'X-RAY DIFFRACTION' 2.55 2.63  . . 140 1668 99.72  . . . . 0.3931 . . . . . . . . . . . 0.4849 
'X-RAY DIFFRACTION' 2.63 2.72  . . 139 1690 99.95  . . . . 0.3733 . . . . . . . . . . . 0.4115 
'X-RAY DIFFRACTION' 2.72 2.83  . . 141 1704 99.89  . . . . 0.3517 . . . . . . . . . . . 0.3800 
'X-RAY DIFFRACTION' 2.83 2.96  . . 142 1658 99.83  . . . . 0.3815 . . . . . . . . . . . 0.4119 
'X-RAY DIFFRACTION' 2.96 3.12  . . 143 1701 99.95  . . . . 0.3787 . . . . . . . . . . . 0.4649 
'X-RAY DIFFRACTION' 3.12 3.31  . . 145 1690 99.89  . . . . 0.3290 . . . . . . . . . . . 0.4191 
'X-RAY DIFFRACTION' 3.31 3.57  . . 146 1701 99.89  . . . . 0.2479 . . . . . . . . . . . 0.3269 
'X-RAY DIFFRACTION' 3.57 3.92  . . 142 1694 99.95  . . . . 0.2392 . . . . . . . . . . . 0.2580 
'X-RAY DIFFRACTION' 3.93 4.49  . . 144 1728 100.00 . . . . 0.1848 . . . . . . . . . . . 0.2061 
'X-RAY DIFFRACTION' 4.50 5.66  . . 144 1728 99.89  . . . . 0.1865 . . . . . . . . . . . 0.2716 
'X-RAY DIFFRACTION' 5.66 46.56 . . 151 1830 99.95  . . . . 0.1763 . . . . . . . . . . . 0.2472 
# 
_struct.entry_id                     8VA9 
_struct.title                        'Crystal structure of FeII/MnII CtCADD from Chlamydia trachomatis' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8VA9 
_struct_keywords.text            'Fe/Mn reconstituted form, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 2 ? 
G N N 3 ? 
H N N 5 ? 
I N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CADD_CHLTR 
_struct_ref.pdbx_db_accession          O84616 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MMEVFMNFLDQLDLIIQNKHMLEHTFYVKWSKGELTKEQLQAYAKDYYLHIKAFPKYLSAIHSRCDDLEARKLLLDNLMD
EENGYPNHIDLWKQFVFALGVTPEELEAHEPSEAAKAKVATFMRWCTGDSLAAGVAALYSYESQIPRIAREKIRGLTEYF
GFSNPEDYAYFTEHEEADVRHAREEKALIEMLLKDDADKVLEASQEVTQSLYGFLDSFLD
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8VA9 A 21 ? 240 ? O84616 1 ? 220 ? 1 220 
2 1 8VA9 B 21 ? 240 ? O84616 1 ? 220 ? 1 220 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8VA9 MET A 1  ? UNP O84616 ? ? 'expression tag' -19 1  
1 8VA9 GLY A 2  ? UNP O84616 ? ? 'expression tag' -18 2  
1 8VA9 SER A 3  ? UNP O84616 ? ? 'expression tag' -17 3  
1 8VA9 SER A 4  ? UNP O84616 ? ? 'expression tag' -16 4  
1 8VA9 HIS A 5  ? UNP O84616 ? ? 'expression tag' -15 5  
1 8VA9 HIS A 6  ? UNP O84616 ? ? 'expression tag' -14 6  
1 8VA9 HIS A 7  ? UNP O84616 ? ? 'expression tag' -13 7  
1 8VA9 HIS A 8  ? UNP O84616 ? ? 'expression tag' -12 8  
1 8VA9 HIS A 9  ? UNP O84616 ? ? 'expression tag' -11 9  
1 8VA9 HIS A 10 ? UNP O84616 ? ? 'expression tag' -10 10 
1 8VA9 SER A 11 ? UNP O84616 ? ? 'expression tag' -9  11 
1 8VA9 SER A 12 ? UNP O84616 ? ? 'expression tag' -8  12 
1 8VA9 GLY A 13 ? UNP O84616 ? ? 'expression tag' -7  13 
1 8VA9 LEU A 14 ? UNP O84616 ? ? 'expression tag' -6  14 
1 8VA9 VAL A 15 ? UNP O84616 ? ? 'expression tag' -5  15 
1 8VA9 PRO A 16 ? UNP O84616 ? ? 'expression tag' -4  16 
1 8VA9 ARG A 17 ? UNP O84616 ? ? 'expression tag' -3  17 
1 8VA9 GLY A 18 ? UNP O84616 ? ? 'expression tag' -2  18 
1 8VA9 SER A 19 ? UNP O84616 ? ? 'expression tag' -1  19 
1 8VA9 HIS A 20 ? UNP O84616 ? ? 'expression tag' 0   20 
2 8VA9 MET B 1  ? UNP O84616 ? ? 'expression tag' -19 21 
2 8VA9 GLY B 2  ? UNP O84616 ? ? 'expression tag' -18 22 
2 8VA9 SER B 3  ? UNP O84616 ? ? 'expression tag' -17 23 
2 8VA9 SER B 4  ? UNP O84616 ? ? 'expression tag' -16 24 
2 8VA9 HIS B 5  ? UNP O84616 ? ? 'expression tag' -15 25 
2 8VA9 HIS B 6  ? UNP O84616 ? ? 'expression tag' -14 26 
2 8VA9 HIS B 7  ? UNP O84616 ? ? 'expression tag' -13 27 
2 8VA9 HIS B 8  ? UNP O84616 ? ? 'expression tag' -12 28 
2 8VA9 HIS B 9  ? UNP O84616 ? ? 'expression tag' -11 29 
2 8VA9 HIS B 10 ? UNP O84616 ? ? 'expression tag' -10 30 
2 8VA9 SER B 11 ? UNP O84616 ? ? 'expression tag' -9  31 
2 8VA9 SER B 12 ? UNP O84616 ? ? 'expression tag' -8  32 
2 8VA9 GLY B 13 ? UNP O84616 ? ? 'expression tag' -7  33 
2 8VA9 LEU B 14 ? UNP O84616 ? ? 'expression tag' -6  34 
2 8VA9 VAL B 15 ? UNP O84616 ? ? 'expression tag' -5  35 
2 8VA9 PRO B 16 ? UNP O84616 ? ? 'expression tag' -4  36 
2 8VA9 ARG B 17 ? UNP O84616 ? ? 'expression tag' -3  37 
2 8VA9 GLY B 18 ? UNP O84616 ? ? 'expression tag' -2  38 
2 8VA9 SER B 19 ? UNP O84616 ? ? 'expression tag' -1  39 
2 8VA9 HIS B 20 ? UNP O84616 ? ? 'expression tag' 0   40 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2500  ? 
1 MORE         -48   ? 
1 'SSA (A^2)'  17900 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,H   
1 2 B,E,F,G,I 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z              1.0000000000  0.0000000000  0.0000000000 0.0000000000   0.0000000000  
1.0000000000 0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 6_444 -x-1,-x+y-1,-z-1/3 -0.5000000000 -0.8660254038 0.0000000000 -46.5620000000 -0.8660254038 
0.5000000000 0.0000000000 -80.6477497020 0.0000000000 0.0000000000 -1.0000000000 -40.3486666667 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 MET A 26  ? LYS A 39  ? MET A 6   LYS A 19  1 ? 14 
HELX_P HELX_P2  AA2 HIS A 40  ? GLU A 43  ? HIS A 20  GLU A 23  5 ? 4  
HELX_P HELX_P3  AA3 HIS A 44  ? LYS A 52  ? HIS A 24  LYS A 32  1 ? 9  
HELX_P HELX_P4  AA4 THR A 56  ? SER A 83  ? THR A 36  SER A 63  1 ? 28 
HELX_P HELX_P5  AA5 ASP A 87  ? ASN A 103 ? ASP A 67  ASN A 83  1 ? 17 
HELX_P HELX_P6  AA6 ASN A 107 ? LEU A 119 ? ASN A 87  LEU A 99  1 ? 13 
HELX_P HELX_P7  AA7 THR A 122 ? ALA A 128 ? THR A 102 ALA A 108 1 ? 7  
HELX_P HELX_P8  AA8 SER A 132 ? GLY A 148 ? SER A 112 GLY A 128 1 ? 17 
HELX_P HELX_P9  AA9 SER A 150 ? SER A 163 ? SER A 130 SER A 143 1 ? 14 
HELX_P HELX_P10 AB1 GLN A 164 ? GLU A 178 ? GLN A 144 GLU A 158 1 ? 15 
HELX_P HELX_P11 AB2 ASN A 184 ? ASP A 187 ? ASN A 164 ASP A 167 5 ? 4  
HELX_P HELX_P12 AB3 TYR A 188 ? LEU A 213 ? TYR A 168 LEU A 193 1 ? 26 
HELX_P HELX_P13 AB4 ASP A 216 ? SER A 237 ? ASP A 196 SER A 217 1 ? 22 
HELX_P HELX_P14 AB5 ASN B 27  ? LYS B 39  ? ASN B 7   LYS B 19  1 ? 13 
HELX_P HELX_P15 AB6 HIS B 40  ? GLU B 43  ? HIS B 20  GLU B 23  5 ? 4  
HELX_P HELX_P16 AB7 HIS B 44  ? LYS B 52  ? HIS B 24  LYS B 32  1 ? 9  
HELX_P HELX_P17 AB8 THR B 56  ? ARG B 84  ? THR B 36  ARG B 64  1 ? 29 
HELX_P HELX_P18 AB9 ASP B 87  ? ASN B 103 ? ASP B 67  ASN B 83  1 ? 17 
HELX_P HELX_P19 AC1 ASN B 107 ? ALA B 118 ? ASN B 87  ALA B 98  1 ? 12 
HELX_P HELX_P20 AC2 THR B 122 ? HIS B 129 ? THR B 102 HIS B 109 1 ? 8  
HELX_P HELX_P21 AC3 SER B 132 ? THR B 147 ? SER B 112 THR B 127 1 ? 16 
HELX_P HELX_P22 AC4 SER B 150 ? SER B 163 ? SER B 130 SER B 143 1 ? 14 
HELX_P HELX_P23 AC5 GLN B 164 ? PHE B 180 ? GLN B 144 PHE B 160 1 ? 17 
HELX_P HELX_P24 AC6 TYR B 188 ? LEU B 213 ? TYR B 168 LEU B 193 1 ? 26 
HELX_P HELX_P25 AC7 ASP B 216 ? SER B 237 ? ASP B 196 SER B 217 1 ? 22 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A GLU 101 OE1 ? ? ? 1_555 C FE2 . FE ? ? A GLU 81  A FE2 301 1_555 ? ? ? ? ? ? ? 2.293 ? ? 
metalc2  metalc ? ? A GLU 101 OE2 ? ? ? 1_555 C FE2 . FE ? ? A GLU 81  A FE2 301 1_555 ? ? ? ? ? ? ? 2.437 ? ? 
metalc3  metalc ? ? A HIS 108 ND1 ? ? ? 1_555 C FE2 . FE ? ? A HIS 88  A FE2 301 1_555 ? ? ? ? ? ? ? 2.403 ? ? 
metalc4  metalc ? ? A GLU 162 OE1 ? ? ? 1_555 D MN  . MN ? ? A GLU 142 A MN  302 1_555 ? ? ? ? ? ? ? 1.978 ? ? 
metalc5  metalc ? ? A HIS 194 NE2 ? ? ? 1_555 C FE2 . FE ? ? A HIS 174 A FE2 301 1_555 ? ? ? ? ? ? ? 1.979 ? ? 
metalc6  metalc ? ? A ASP 198 OD1 ? ? ? 1_555 D MN  . MN ? ? A ASP 178 A MN  302 1_555 ? ? ? ? ? ? ? 1.928 ? ? 
metalc7  metalc ? ? A HIS 201 ND1 ? ? ? 1_555 D MN  . MN ? ? A HIS 181 A MN  302 1_555 ? ? ? ? ? ? ? 2.244 ? ? 
metalc8  metalc ? ? C FE2 .   FE  ? ? ? 1_555 H HOH . O  ? ? A FE2 301 A HOH 411 1_555 ? ? ? ? ? ? ? 2.260 ? ? 
metalc9  metalc ? ? D MN  .   MN  ? ? ? 1_555 H HOH . O  ? ? A MN  302 A HOH 411 1_555 ? ? ? ? ? ? ? 2.252 ? ? 
metalc10 metalc ? ? D MN  .   MN  ? ? ? 1_555 H HOH . O  ? ? A MN  302 A HOH 416 1_555 ? ? ? ? ? ? ? 1.963 ? ? 
metalc11 metalc ? ? D MN  .   MN  ? ? ? 1_555 H HOH . O  ? ? A MN  302 A HOH 424 1_555 ? ? ? ? ? ? ? 2.405 ? ? 
metalc12 metalc ? ? B GLU 101 OE2 ? ? ? 1_555 F FE2 . FE ? ? B GLU 81  B FE2 302 1_555 ? ? ? ? ? ? ? 1.979 ? ? 
metalc13 metalc ? ? B HIS 108 ND1 ? ? ? 1_555 F FE2 . FE ? ? B HIS 88  B FE2 302 1_555 ? ? ? ? ? ? ? 2.376 ? ? 
metalc14 metalc ? ? B GLU 162 OE2 ? ? ? 1_555 G MN  . MN ? ? B GLU 142 B MN  303 1_555 ? ? ? ? ? ? ? 2.271 ? ? 
metalc15 metalc ? ? B HIS 194 NE2 ? ? ? 1_555 F FE2 . FE ? ? B HIS 174 B FE2 302 1_555 ? ? ? ? ? ? ? 2.095 ? ? 
metalc16 metalc ? ? B ASP 198 OD1 ? ? ? 1_555 G MN  . MN ? ? B ASP 178 B MN  303 1_555 ? ? ? ? ? ? ? 2.005 ? ? 
metalc17 metalc ? ? B HIS 201 ND1 ? ? ? 1_555 G MN  . MN ? ? B HIS 181 B MN  303 1_555 ? ? ? ? ? ? ? 2.218 ? ? 
metalc18 metalc ? ? G MN  .   MN  ? ? ? 1_555 I HOH . O  ? ? B MN  303 B HOH 407 1_555 ? ? ? ? ? ? ? 2.018 ? ? 
metalc19 metalc ? ? G MN  .   MN  ? ? ? 1_555 I HOH . O  ? ? B MN  303 B HOH 419 1_555 ? ? ? ? ? ? ? 2.547 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 OE2 ? A GLU 101 ? A GLU 81  ? 1_555 55.3  ? 
2  OE1 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 ND1 ? A HIS 108 ? A HIS 88  ? 1_555 84.5  ? 
3  OE2 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 ND1 ? A HIS 108 ? A HIS 88  ? 1_555 91.1  ? 
4  OE1 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 NE2 ? A HIS 194 ? A HIS 174 ? 1_555 149.8 ? 
5  OE2 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 NE2 ? A HIS 194 ? A HIS 174 ? 1_555 152.9 ? 
6  ND1 ? A HIS 108 ? A HIS 88  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 NE2 ? A HIS 194 ? A HIS 174 ? 1_555 84.4  ? 
7  OE1 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 75.5  ? 
8  OE2 ? A GLU 101 ? A GLU 81  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 130.8 ? 
9  ND1 ? A HIS 108 ? A HIS 88  ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 81.7  ? 
10 NE2 ? A HIS 194 ? A HIS 174 ? 1_555 FE ? C FE2 . ? A FE2 301 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 75.1  ? 
11 OE1 ? A GLU 162 ? A GLU 142 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 OD1 ? A ASP 198 ? A ASP 178 ? 1_555 78.8  ? 
12 OE1 ? A GLU 162 ? A GLU 142 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 ND1 ? A HIS 201 ? A HIS 181 ? 1_555 99.5  ? 
13 OD1 ? A ASP 198 ? A ASP 178 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 ND1 ? A HIS 201 ? A HIS 181 ? 1_555 81.6  ? 
14 OE1 ? A GLU 162 ? A GLU 142 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 159.0 ? 
15 OD1 ? A ASP 198 ? A ASP 178 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 101.1 ? 
16 ND1 ? A HIS 201 ? A HIS 181 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 411 ? 1_555 101.3 ? 
17 OE1 ? A GLU 162 ? A GLU 142 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 416 ? 1_555 99.3  ? 
18 OD1 ? A ASP 198 ? A ASP 178 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 416 ? 1_555 170.8 ? 
19 ND1 ? A HIS 201 ? A HIS 181 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 416 ? 1_555 107.6 ? 
20 O   ? H HOH .   ? A HOH 411 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 416 ? 1_555 77.4  ? 
21 OE1 ? A GLU 162 ? A GLU 142 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 424 ? 1_555 88.2  ? 
22 OD1 ? A ASP 198 ? A ASP 178 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 424 ? 1_555 103.4 ? 
23 ND1 ? A HIS 201 ? A HIS 181 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 424 ? 1_555 171.6 ? 
24 O   ? H HOH .   ? A HOH 411 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 424 ? 1_555 71.3  ? 
25 O   ? H HOH .   ? A HOH 416 ? 1_555 MN ? D MN  . ? A MN  302 ? 1_555 O   ? H HOH .   ? A HOH 424 ? 1_555 67.4  ? 
26 OE2 ? B GLU 101 ? B GLU 81  ? 1_555 FE ? F FE2 . ? B FE2 302 ? 1_555 ND1 ? B HIS 108 ? B HIS 88  ? 1_555 77.6  ? 
27 OE2 ? B GLU 101 ? B GLU 81  ? 1_555 FE ? F FE2 . ? B FE2 302 ? 1_555 NE2 ? B HIS 194 ? B HIS 174 ? 1_555 121.8 ? 
28 ND1 ? B HIS 108 ? B HIS 88  ? 1_555 FE ? F FE2 . ? B FE2 302 ? 1_555 NE2 ? B HIS 194 ? B HIS 174 ? 1_555 84.5  ? 
29 OE2 ? B GLU 162 ? B GLU 142 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 OD1 ? B ASP 198 ? B ASP 178 ? 1_555 91.3  ? 
30 OE2 ? B GLU 162 ? B GLU 142 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 ND1 ? B HIS 201 ? B HIS 181 ? 1_555 88.5  ? 
31 OD1 ? B ASP 198 ? B ASP 178 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 ND1 ? B HIS 201 ? B HIS 181 ? 1_555 73.6  ? 
32 OE2 ? B GLU 162 ? B GLU 142 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 407 ? 1_555 69.5  ? 
33 OD1 ? B ASP 198 ? B ASP 178 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 407 ? 1_555 158.7 ? 
34 ND1 ? B HIS 201 ? B HIS 181 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 407 ? 1_555 96.0  ? 
35 OE2 ? B GLU 162 ? B GLU 142 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 419 ? 1_555 92.7  ? 
36 OD1 ? B ASP 198 ? B ASP 178 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 419 ? 1_555 115.4 ? 
37 ND1 ? B HIS 201 ? B HIS 181 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 419 ? 1_555 170.9 ? 
38 O   ? I HOH .   ? B HOH 407 ? 1_555 MN ? G MN  . ? B MN  303 ? 1_555 O   ? I HOH .   ? B HOH 419 ? 1_555 76.0  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TYR 105 A . ? TYR 85 A PRO 106 A ? PRO 86 A 1 -4.81 
2 TYR 105 B . ? TYR 85 B PRO 106 B ? PRO 86 B 1 -7.39 
# 
_pdbx_entry_details.entry_id                   8VA9 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 67  ? ? -69.54  98.17   
2 1 GLU A 158 ? ? -68.27  -103.30 
3 1 TYR A 168 ? ? -93.82  41.60   
4 1 LYS B 19  ? ? -104.50 54.16   
5 1 GLU B 34  ? ? -59.63  51.39   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+2/3   
3 -x+y,-x,z+1/3  
4 x-y,-y,-z+1/3  
5 -x,-x+y,-z+2/3 
6 y,x,-z         
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       435 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   7.00 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -19 ? A MET 1   
2  1 Y 1 A GLY -18 ? A GLY 2   
3  1 Y 1 A SER -17 ? A SER 3   
4  1 Y 1 A SER -16 ? A SER 4   
5  1 Y 1 A HIS -15 ? A HIS 5   
6  1 Y 1 A HIS -14 ? A HIS 6   
7  1 Y 1 A HIS -13 ? A HIS 7   
8  1 Y 1 A HIS -12 ? A HIS 8   
9  1 Y 1 A HIS -11 ? A HIS 9   
10 1 Y 1 A HIS -10 ? A HIS 10  
11 1 Y 1 A SER -9  ? A SER 11  
12 1 Y 1 A SER -8  ? A SER 12  
13 1 Y 1 A GLY -7  ? A GLY 13  
14 1 Y 1 A LEU -6  ? A LEU 14  
15 1 Y 1 A VAL -5  ? A VAL 15  
16 1 Y 1 A PRO -4  ? A PRO 16  
17 1 Y 1 A ARG -3  ? A ARG 17  
18 1 Y 1 A GLY -2  ? A GLY 18  
19 1 Y 1 A SER -1  ? A SER 19  
20 1 Y 1 A HIS 0   ? A HIS 20  
21 1 Y 1 A MET 1   ? A MET 21  
22 1 Y 1 A MET 2   ? A MET 22  
23 1 Y 1 A GLU 3   ? A GLU 23  
24 1 Y 1 A VAL 4   ? A VAL 24  
25 1 Y 1 A PHE 5   ? A PHE 25  
26 1 Y 1 A ASP 220 ? A ASP 240 
27 1 Y 1 B MET -19 ? B MET 1   
28 1 Y 1 B GLY -18 ? B GLY 2   
29 1 Y 1 B SER -17 ? B SER 3   
30 1 Y 1 B SER -16 ? B SER 4   
31 1 Y 1 B HIS -15 ? B HIS 5   
32 1 Y 1 B HIS -14 ? B HIS 6   
33 1 Y 1 B HIS -13 ? B HIS 7   
34 1 Y 1 B HIS -12 ? B HIS 8   
35 1 Y 1 B HIS -11 ? B HIS 9   
36 1 Y 1 B HIS -10 ? B HIS 10  
37 1 Y 1 B SER -9  ? B SER 11  
38 1 Y 1 B SER -8  ? B SER 12  
39 1 Y 1 B GLY -7  ? B GLY 13  
40 1 Y 1 B LEU -6  ? B LEU 14  
41 1 Y 1 B VAL -5  ? B VAL 15  
42 1 Y 1 B PRO -4  ? B PRO 16  
43 1 Y 1 B ARG -3  ? B ARG 17  
44 1 Y 1 B GLY -2  ? B GLY 18  
45 1 Y 1 B SER -1  ? B SER 19  
46 1 Y 1 B HIS 0   ? B HIS 20  
47 1 Y 1 B MET 1   ? B MET 21  
48 1 Y 1 B MET 2   ? B MET 22  
49 1 Y 1 B GLU 3   ? B GLU 23  
50 1 Y 1 B VAL 4   ? B VAL 24  
51 1 Y 1 B PHE 5   ? B PHE 25  
52 1 Y 1 B ASP 220 ? B ASP 240 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
FE2 FE   FE N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
GOL C1   C  N N 138 
GOL O1   O  N N 139 
GOL C2   C  N N 140 
GOL O2   O  N N 141 
GOL C3   C  N N 142 
GOL O3   O  N N 143 
GOL H11  H  N N 144 
GOL H12  H  N N 145 
GOL HO1  H  N N 146 
GOL H2   H  N N 147 
GOL HO2  H  N N 148 
GOL H31  H  N N 149 
GOL H32  H  N N 150 
GOL HO3  H  N N 151 
HIS N    N  N N 152 
HIS CA   C  N S 153 
HIS C    C  N N 154 
HIS O    O  N N 155 
HIS CB   C  N N 156 
HIS CG   C  Y N 157 
HIS ND1  N  Y N 158 
HIS CD2  C  Y N 159 
HIS CE1  C  Y N 160 
HIS NE2  N  Y N 161 
HIS OXT  O  N N 162 
HIS H    H  N N 163 
HIS H2   H  N N 164 
HIS HA   H  N N 165 
HIS HB2  H  N N 166 
HIS HB3  H  N N 167 
HIS HD1  H  N N 168 
HIS HD2  H  N N 169 
HIS HE1  H  N N 170 
HIS HE2  H  N N 171 
HIS HXT  H  N N 172 
HOH O    O  N N 173 
HOH H1   H  N N 174 
HOH H2   H  N N 175 
ILE N    N  N N 176 
ILE CA   C  N S 177 
ILE C    C  N N 178 
ILE O    O  N N 179 
ILE CB   C  N S 180 
ILE CG1  C  N N 181 
ILE CG2  C  N N 182 
ILE CD1  C  N N 183 
ILE OXT  O  N N 184 
ILE H    H  N N 185 
ILE H2   H  N N 186 
ILE HA   H  N N 187 
ILE HB   H  N N 188 
ILE HG12 H  N N 189 
ILE HG13 H  N N 190 
ILE HG21 H  N N 191 
ILE HG22 H  N N 192 
ILE HG23 H  N N 193 
ILE HD11 H  N N 194 
ILE HD12 H  N N 195 
ILE HD13 H  N N 196 
ILE HXT  H  N N 197 
LEU N    N  N N 198 
LEU CA   C  N S 199 
LEU C    C  N N 200 
LEU O    O  N N 201 
LEU CB   C  N N 202 
LEU CG   C  N N 203 
LEU CD1  C  N N 204 
LEU CD2  C  N N 205 
LEU OXT  O  N N 206 
LEU H    H  N N 207 
LEU H2   H  N N 208 
LEU HA   H  N N 209 
LEU HB2  H  N N 210 
LEU HB3  H  N N 211 
LEU HG   H  N N 212 
LEU HD11 H  N N 213 
LEU HD12 H  N N 214 
LEU HD13 H  N N 215 
LEU HD21 H  N N 216 
LEU HD22 H  N N 217 
LEU HD23 H  N N 218 
LEU HXT  H  N N 219 
LYS N    N  N N 220 
LYS CA   C  N S 221 
LYS C    C  N N 222 
LYS O    O  N N 223 
LYS CB   C  N N 224 
LYS CG   C  N N 225 
LYS CD   C  N N 226 
LYS CE   C  N N 227 
LYS NZ   N  N N 228 
LYS OXT  O  N N 229 
LYS H    H  N N 230 
LYS H2   H  N N 231 
LYS HA   H  N N 232 
LYS HB2  H  N N 233 
LYS HB3  H  N N 234 
LYS HG2  H  N N 235 
LYS HG3  H  N N 236 
LYS HD2  H  N N 237 
LYS HD3  H  N N 238 
LYS HE2  H  N N 239 
LYS HE3  H  N N 240 
LYS HZ1  H  N N 241 
LYS HZ2  H  N N 242 
LYS HZ3  H  N N 243 
LYS HXT  H  N N 244 
MET N    N  N N 245 
MET CA   C  N S 246 
MET C    C  N N 247 
MET O    O  N N 248 
MET CB   C  N N 249 
MET CG   C  N N 250 
MET SD   S  N N 251 
MET CE   C  N N 252 
MET OXT  O  N N 253 
MET H    H  N N 254 
MET H2   H  N N 255 
MET HA   H  N N 256 
MET HB2  H  N N 257 
MET HB3  H  N N 258 
MET HG2  H  N N 259 
MET HG3  H  N N 260 
MET HE1  H  N N 261 
MET HE2  H  N N 262 
MET HE3  H  N N 263 
MET HXT  H  N N 264 
MN  MN   MN N N 265 
PHE N    N  N N 266 
PHE CA   C  N S 267 
PHE C    C  N N 268 
PHE O    O  N N 269 
PHE CB   C  N N 270 
PHE CG   C  Y N 271 
PHE CD1  C  Y N 272 
PHE CD2  C  Y N 273 
PHE CE1  C  Y N 274 
PHE CE2  C  Y N 275 
PHE CZ   C  Y N 276 
PHE OXT  O  N N 277 
PHE H    H  N N 278 
PHE H2   H  N N 279 
PHE HA   H  N N 280 
PHE HB2  H  N N 281 
PHE HB3  H  N N 282 
PHE HD1  H  N N 283 
PHE HD2  H  N N 284 
PHE HE1  H  N N 285 
PHE HE2  H  N N 286 
PHE HZ   H  N N 287 
PHE HXT  H  N N 288 
PRO N    N  N N 289 
PRO CA   C  N S 290 
PRO C    C  N N 291 
PRO O    O  N N 292 
PRO CB   C  N N 293 
PRO CG   C  N N 294 
PRO CD   C  N N 295 
PRO OXT  O  N N 296 
PRO H    H  N N 297 
PRO HA   H  N N 298 
PRO HB2  H  N N 299 
PRO HB3  H  N N 300 
PRO HG2  H  N N 301 
PRO HG3  H  N N 302 
PRO HD2  H  N N 303 
PRO HD3  H  N N 304 
PRO HXT  H  N N 305 
SER N    N  N N 306 
SER CA   C  N S 307 
SER C    C  N N 308 
SER O    O  N N 309 
SER CB   C  N N 310 
SER OG   O  N N 311 
SER OXT  O  N N 312 
SER H    H  N N 313 
SER H2   H  N N 314 
SER HA   H  N N 315 
SER HB2  H  N N 316 
SER HB3  H  N N 317 
SER HG   H  N N 318 
SER HXT  H  N N 319 
THR N    N  N N 320 
THR CA   C  N S 321 
THR C    C  N N 322 
THR O    O  N N 323 
THR CB   C  N R 324 
THR OG1  O  N N 325 
THR CG2  C  N N 326 
THR OXT  O  N N 327 
THR H    H  N N 328 
THR H2   H  N N 329 
THR HA   H  N N 330 
THR HB   H  N N 331 
THR HG1  H  N N 332 
THR HG21 H  N N 333 
THR HG22 H  N N 334 
THR HG23 H  N N 335 
THR HXT  H  N N 336 
TRP N    N  N N 337 
TRP CA   C  N S 338 
TRP C    C  N N 339 
TRP O    O  N N 340 
TRP CB   C  N N 341 
TRP CG   C  Y N 342 
TRP CD1  C  Y N 343 
TRP CD2  C  Y N 344 
TRP NE1  N  Y N 345 
TRP CE2  C  Y N 346 
TRP CE3  C  Y N 347 
TRP CZ2  C  Y N 348 
TRP CZ3  C  Y N 349 
TRP CH2  C  Y N 350 
TRP OXT  O  N N 351 
TRP H    H  N N 352 
TRP H2   H  N N 353 
TRP HA   H  N N 354 
TRP HB2  H  N N 355 
TRP HB3  H  N N 356 
TRP HD1  H  N N 357 
TRP HE1  H  N N 358 
TRP HE3  H  N N 359 
TRP HZ2  H  N N 360 
TRP HZ3  H  N N 361 
TRP HH2  H  N N 362 
TRP HXT  H  N N 363 
TYR N    N  N N 364 
TYR CA   C  N S 365 
TYR C    C  N N 366 
TYR O    O  N N 367 
TYR CB   C  N N 368 
TYR CG   C  Y N 369 
TYR CD1  C  Y N 370 
TYR CD2  C  Y N 371 
TYR CE1  C  Y N 372 
TYR CE2  C  Y N 373 
TYR CZ   C  Y N 374 
TYR OH   O  N N 375 
TYR OXT  O  N N 376 
TYR H    H  N N 377 
TYR H2   H  N N 378 
TYR HA   H  N N 379 
TYR HB2  H  N N 380 
TYR HB3  H  N N 381 
TYR HD1  H  N N 382 
TYR HD2  H  N N 383 
TYR HE1  H  N N 384 
TYR HE2  H  N N 385 
TYR HH   H  N N 386 
TYR HXT  H  N N 387 
VAL N    N  N N 388 
VAL CA   C  N S 389 
VAL C    C  N N 390 
VAL O    O  N N 391 
VAL CB   C  N N 392 
VAL CG1  C  N N 393 
VAL CG2  C  N N 394 
VAL OXT  O  N N 395 
VAL H    H  N N 396 
VAL H2   H  N N 397 
VAL HA   H  N N 398 
VAL HB   H  N N 399 
VAL HG11 H  N N 400 
VAL HG12 H  N N 401 
VAL HG13 H  N N 402 
VAL HG21 H  N N 403 
VAL HG22 H  N N 404 
VAL HG23 H  N N 405 
VAL HXT  H  N N 406 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           GM135315 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8VA8 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 32 2 1' 
_space_group.name_Hall        
;P 32 2"
;
_space_group.IT_number        154 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8VA9 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010738 
_atom_sites.fract_transf_matrix[1][2]   0.006200 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012400 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008261 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
FE ? ? 20.90327 4.99816 ? ? 2.55100  38.46870 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MN ? ? 20.23591 4.67902 ? ? 2.76514  44.01191 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    C  CA  . MET A 1 26  ? -61.22541 23.19322 -11.09145 1.000 31.63000  ? 6   MET A CA  1 
ATOM   2    C  C   . MET A 1 26  ? -60.10382 24.08200 -10.53944 1.000 31.63000  ? 6   MET A C   1 
ATOM   3    O  O   . MET A 1 26  ? -58.89737 23.92207 -10.96140 1.000 31.63000  ? 6   MET A O   1 
ATOM   4    N  N   . ASN A 1 27  ? -60.48437 25.01500 -9.65320  1.000 69.98000  ? 7   ASN A N   1 
ATOM   5    C  CA  . ASN A 1 27  ? -59.59733 25.88603 -8.88930  1.000 66.59000  ? 7   ASN A CA  1 
ATOM   6    C  C   . ASN A 1 27  ? -58.38480 25.11578 -8.36607  1.000 63.53000  ? 7   ASN A C   1 
ATOM   7    O  O   . ASN A 1 27  ? -57.29204 25.68372 -8.24860  1.000 67.17000  ? 7   ASN A O   1 
ATOM   8    C  CB  . ASN A 1 27  ? -60.41965 26.53131 -7.73515  1.000 75.41000  ? 7   ASN A CB  1 
ATOM   9    C  CG  . ASN A 1 27  ? -59.66319 27.64331 -6.92616  1.000 83.77000  ? 7   ASN A CG  1 
ATOM   10   O  OD1 . ASN A 1 27  ? -58.43078 27.71796 -6.88986  1.000 90.34000  ? 7   ASN A OD1 1 
ATOM   11   N  ND2 . ASN A 1 27  ? -60.44141 28.49452 -6.25566  1.000 84.71000  ? 7   ASN A ND2 1 
ATOM   12   N  N   . PHE A 1 28  ? -58.54938 23.82805 -8.03757  1.000 53.94000  ? 8   PHE A N   1 
ATOM   13   C  CA  . PHE A 1 28  ? -57.45800 23.11964 -7.36309  1.000 59.28000  ? 8   PHE A CA  1 
ATOM   14   C  C   . PHE A 1 28  ? -56.32678 22.80488 -8.32440  1.000 61.92000  ? 8   PHE A C   1 
ATOM   15   O  O   . PHE A 1 28  ? -55.14668 22.88040 -7.95532  1.000 59.11000  ? 8   PHE A O   1 
ATOM   16   C  CB  . PHE A 1 28  ? -57.98598 21.85772 -6.68122  1.000 56.98000  ? 8   PHE A CB  1 
ATOM   17   C  CG  . PHE A 1 28  ? -58.02622 20.65229 -7.54646  1.000 60.66000  ? 8   PHE A CG  1 
ATOM   18   C  CD1 . PHE A 1 28  ? -56.92201 19.83571 -7.67206  1.000 61.43000  ? 8   PHE A CD1 1 
ATOM   19   C  CD2 . PHE A 1 28  ? -59.20416 20.30186 -8.20887  1.000 61.36000  ? 8   PHE A CD2 1 
ATOM   20   C  CE1 . PHE A 1 28  ? -56.97462 18.69984 -8.46171  1.000 55.17000  ? 8   PHE A CE1 1 
ATOM   21   C  CE2 . PHE A 1 28  ? -59.27041 19.16398 -9.01646  1.000 63.30000  ? 8   PHE A CE2 1 
ATOM   22   C  CZ  . PHE A 1 28  ? -58.15374 18.36533 -9.14572  1.000 64.74000  ? 8   PHE A CZ  1 
ATOM   23   N  N   . LEU A 1 29  ? -56.68409 22.48189 -9.56776  1.000 60.57000  ? 9   LEU A N   1 
ATOM   24   C  CA  . LEU A 1 29  ? -55.70350 22.38800 -10.63706 1.000 60.31000  ? 9   LEU A CA  1 
ATOM   25   C  C   . LEU A 1 29  ? -54.86194 23.65319 -10.71686 1.000 54.44000  ? 9   LEU A C   1 
ATOM   26   O  O   . LEU A 1 29  ? -53.63359 23.58467 -10.81778 1.000 53.75000  ? 9   LEU A O   1 
ATOM   27   C  CB  . LEU A 1 29  ? -56.43090 22.11263 -11.94560 1.000 55.80000  ? 9   LEU A CB  1 
ATOM   28   C  CG  . LEU A 1 29  ? -57.00737 20.70864 -11.92716 1.000 61.23000  ? 9   LEU A CG  1 
ATOM   29   C  CD1 . LEU A 1 29  ? -57.58628 20.32974 -13.27711 1.000 62.27000  ? 9   LEU A CD1 1 
ATOM   30   C  CD2 . LEU A 1 29  ? -55.90122 19.75879 -11.50647 1.000 53.41000  ? 9   LEU A CD2 1 
ATOM   31   N  N   . ASP A 1 30  ? -55.50653 24.82193 -10.61534 1.000 51.85000  ? 10  ASP A N   1 
ATOM   32   C  CA  . ASP A 1 30  ? -54.76254 26.07969 -10.56534 1.000 52.15000  ? 10  ASP A CA  1 
ATOM   33   C  C   . ASP A 1 30  ? -53.94489 26.21726 -9.27684  1.000 58.76000  ? 10  ASP A C   1 
ATOM   34   O  O   . ASP A 1 30  ? -52.85347 26.80601 -9.28380  1.000 58.77000  ? 10  ASP A O   1 
ATOM   35   C  CB  . ASP A 1 30  ? -55.71952 27.26555 -10.72901 1.000 58.29000  ? 10  ASP A CB  1 
ATOM   36   C  CG  . ASP A 1 30  ? -56.61823 27.13636 -11.95974 1.000 62.09000  ? 10  ASP A CG  1 
ATOM   37   O  OD1 . ASP A 1 30  ? -56.14802 26.62761 -13.00698 1.000 65.91000  ? 10  ASP A OD1 1 
ATOM   38   O  OD2 . ASP A 1 30  ? -57.79686 27.54562 -11.88348 1.000 64.08000  ? 10  ASP A OD2 1 
ATOM   39   N  N   . GLN A 1 31  ? -54.45953 25.71234 -8.14853  1.000 59.09000  ? 11  GLN A N   1 
ATOM   40   C  CA  . GLN A 1 31  ? -53.64805 25.76986 -6.93489  1.000 60.56000  ? 11  GLN A CA  1 
ATOM   41   C  C   . GLN A 1 31  ? -52.45948 24.83204 -7.04850  1.000 61.77000  ? 11  GLN A C   1 
ATOM   42   O  O   . GLN A 1 31  ? -51.34657 25.15830 -6.59348  1.000 52.17000  ? 11  GLN A O   1 
ATOM   43   C  CB  . GLN A 1 31  ? -54.47024 25.42360 -5.69252  1.000 59.55000  ? 11  GLN A CB  1 
ATOM   44   C  CG  . GLN A 1 31  ? -54.16629 26.31793 -4.47862  1.000 76.60000  ? 11  GLN A CG  1 
ATOM   45   N  N   . LEU A 1 32  ? -52.67603 23.66148 -7.66508  1.000 54.89000  ? 12  LEU A N   1 
ATOM   46   C  CA  . LEU A 1 32  ? -51.57193 22.72299 -7.82586  1.000 62.32000  ? 12  LEU A CA  1 
ATOM   47   C  C   . LEU A 1 32  ? -50.44123 23.35687 -8.63028  1.000 61.30000  ? 12  LEU A C   1 
ATOM   48   O  O   . LEU A 1 32  ? -49.26866 23.24200 -8.25074  1.000 60.55000  ? 12  LEU A O   1 
ATOM   49   C  CB  . LEU A 1 32  ? -52.07772 21.42922 -8.45906  1.000 54.07000  ? 12  LEU A CB  1 
ATOM   50   C  CG  . LEU A 1 32  ? -51.07068 20.54643 -9.19109  1.000 53.21000  ? 12  LEU A CG  1 
ATOM   51   C  CD1 . LEU A 1 32  ? -49.99344 20.05474 -8.25272  1.000 52.65000  ? 12  LEU A CD1 1 
ATOM   52   C  CD2 . LEU A 1 32  ? -51.74942 19.37267 -9.92945  1.000 54.31000  ? 12  LEU A CD2 1 
ATOM   53   N  N   . ASP A 1 33  ? -50.78821 24.10325 -9.69173  1.000 51.13000  ? 13  ASP A N   1 
ATOM   54   C  CA  . ASP A 1 33  ? -49.78846 24.75371 -10.53701 1.000 56.30000  ? 13  ASP A CA  1 
ATOM   55   C  C   . ASP A 1 33  ? -49.08518 25.88392 -9.80491  1.000 60.41000  ? 13  ASP A C   1 
ATOM   56   O  O   . ASP A 1 33  ? -47.90483 26.14807 -10.05462 1.000 63.09000  ? 13  ASP A O   1 
ATOM   57   C  CB  . ASP A 1 33  ? -50.44325 25.29360 -11.82514 1.000 60.07000  ? 13  ASP A CB  1 
ATOM   58   C  CG  . ASP A 1 33  ? -50.46654 24.26232 -12.94811 1.000 65.54000  ? 13  ASP A CG  1 
ATOM   59   O  OD1 . ASP A 1 33  ? -49.45420 23.56082 -13.11398 1.000 67.34000  ? 13  ASP A OD1 1 
ATOM   60   O  OD2 . ASP A 1 33  ? -51.49550 24.12900 -13.64514 1.000 59.54000  ? 13  ASP A OD2 1 
ATOM   61   N  N   . LEU A 1 34  ? -49.80223 26.57635 -8.92356  1.000 62.50000  ? 14  LEU A N   1 
ATOM   62   C  CA  . LEU A 1 34  ? -49.20986 27.67428 -8.16964  1.000 60.34000  ? 14  LEU A CA  1 
ATOM   63   C  C   . LEU A 1 34  ? -48.24160 27.16189 -7.11336  1.000 62.28000  ? 14  LEU A C   1 
ATOM   64   O  O   . LEU A 1 34  ? -47.22707 27.81579 -6.82125  1.000 61.62000  ? 14  LEU A O   1 
ATOM   65   C  CB  . LEU A 1 34  ? -50.32192 28.49803 -7.53881  1.000 63.04000  ? 14  LEU A CB  1 
ATOM   66   C  CG  . LEU A 1 34  ? -50.78473 29.65453 -8.41056  1.000 66.88000  ? 14  LEU A CG  1 
ATOM   67   C  CD1 . LEU A 1 34  ? -51.89944 30.39767 -7.72473  1.000 71.63000  ? 14  LEU A CD1 1 
ATOM   68   C  CD2 . LEU A 1 34  ? -49.60365 30.58199 -8.67811  1.000 58.36000  ? 14  LEU A CD2 1 
ATOM   69   N  N   . ILE A 1 35  ? -48.52801 25.99852 -6.52101  1.000 55.88000  ? 15  ILE A N   1 
ATOM   70   C  CA  . ILE A 1 35  ? -47.53673 25.39458 -5.62913  1.000 58.27000  ? 15  ILE A CA  1 
ATOM   71   C  C   . ILE A 1 35  ? -46.22527 25.23688 -6.37452  1.000 63.45000  ? 15  ILE A C   1 
ATOM   72   O  O   . ILE A 1 35  ? -45.17549 25.72628 -5.93900  1.000 65.02000  ? 15  ILE A O   1 
ATOM   73   C  CB  . ILE A 1 35  ? -48.03419 24.04132 -5.08026  1.000 66.31000  ? 15  ILE A CB  1 
ATOM   74   C  CG1 . ILE A 1 35  ? -49.06467 24.21926 -3.98153  1.000 61.58000  ? 15  ILE A CG1 1 
ATOM   75   C  CG2 . ILE A 1 35  ? -46.89757 23.21993 -4.52152  1.000 61.90000  ? 15  ILE A CG2 1 
ATOM   76   C  CD1 . ILE A 1 35  ? -49.74160 22.94142 -3.62087  1.000 61.41000  ? 15  ILE A CD1 1 
ATOM   77   N  N   . ILE A 1 36  ? -46.30240 24.65017 -7.57341  1.000 59.56000  ? 16  ILE A N   1 
ATOM   78   C  CA  . ILE A 1 36  ? -45.11301 24.27829 -8.32792  1.000 53.63000  ? 16  ILE A CA  1 
ATOM   79   C  C   . ILE A 1 36  ? -44.32130 25.51823 -8.71467  1.000 61.24000  ? 16  ILE A C   1 
ATOM   80   O  O   . ILE A 1 36  ? -43.11457 25.60067 -8.45573  1.000 61.44000  ? 16  ILE A O   1 
ATOM   81   C  CB  . ILE A 1 36  ? -45.52260 23.44865 -9.55119  1.000 61.79000  ? 16  ILE A CB  1 
ATOM   82   C  CG1 . ILE A 1 36  ? -46.23482 22.18754 -9.07995  1.000 55.89000  ? 16  ILE A CG1 1 
ATOM   83   C  CG2 . ILE A 1 36  ? -44.28913 23.05115 -10.34226 1.000 55.84000  ? 16  ILE A CG2 1 
ATOM   84   C  CD1 . ILE A 1 36  ? -46.76060 21.32389 -10.18503 1.000 55.23000  ? 16  ILE A CD1 1 
ATOM   85   N  N   . GLN A 1 37  ? -44.98706 26.48847 -9.36011  1.000 56.42000  ? 17  GLN A N   1 
ATOM   86   C  CA  . GLN A 1 37  ? -44.40390 27.81246 -9.58900  1.000 64.38000  ? 17  GLN A CA  1 
ATOM   87   C  C   . GLN A 1 37  ? -43.64572 28.36151 -8.38203  1.000 70.99000  ? 17  GLN A C   1 
ATOM   88   O  O   . GLN A 1 37  ? -42.47972 28.75545 -8.49688  1.000 74.27000  ? 17  GLN A O   1 
ATOM   89   C  CB  . GLN A 1 37  ? -45.50236 28.80416 -9.98076  1.000 65.52000  ? 17  GLN A CB  1 
ATOM   90   C  CG  . GLN A 1 37  ? -45.05709 29.84847 -10.98345 1.000 77.79000  ? 17  GLN A CG  1 
ATOM   91   C  CD  . GLN A 1 37  ? -46.17961 30.34773 -11.88899 1.000 87.28000  ? 17  GLN A CD  1 
ATOM   92   O  OE1 . GLN A 1 37  ? -47.03009 31.15651 -11.47425 1.000 77.78000  ? 17  GLN A OE1 1 
ATOM   93   N  NE2 . GLN A 1 37  ? -46.15666 29.90462 -13.15074 1.000 84.53000  ? 17  GLN A NE2 1 
ATOM   94   N  N   . ASN A 1 38  ? -44.30463 28.43060 -7.21760  1.000 65.07000  ? 18  ASN A N   1 
ATOM   95   C  CA  . ASN A 1 38  ? -43.67222 29.10655 -6.08826  1.000 75.96000  ? 18  ASN A CA  1 
ATOM   96   C  C   . ASN A 1 38  ? -42.50241 28.31004 -5.51805  1.000 75.15000  ? 18  ASN A C   1 
ATOM   97   O  O   . ASN A 1 38  ? -41.66488 28.87218 -4.79901  1.000 80.91000  ? 18  ASN A O   1 
ATOM   98   C  CB  . ASN A 1 38  ? -44.70114 29.39777 -4.99427  1.000 73.67000  ? 18  ASN A CB  1 
ATOM   99   C  CG  . ASN A 1 38  ? -45.43289 30.71530 -5.21453  1.000 76.88000  ? 18  ASN A CG  1 
ATOM   100  O  OD1 . ASN A 1 38  ? -44.99253 31.78322 -4.75960  1.000 82.43000  ? 18  ASN A OD1 1 
ATOM   101  N  ND2 . ASN A 1 38  ? -46.57151 30.64208 -5.89674  1.000 71.30000  ? 18  ASN A ND2 1 
ATOM   102  N  N   . LYS A 1 39  ? -42.41689 27.02248 -5.83890  1.000 70.20000  ? 19  LYS A N   1 
ATOM   103  C  CA  . LYS A 1 39  ? -41.30772 26.18465 -5.41486  1.000 68.82000  ? 19  LYS A CA  1 
ATOM   104  C  C   . LYS A 1 39  ? -40.73663 25.45640 -6.64050  1.000 68.79000  ? 19  LYS A C   1 
ATOM   105  O  O   . LYS A 1 39  ? -40.74782 24.23204 -6.73967  1.000 67.02000  ? 19  LYS A O   1 
ATOM   106  C  CB  . LYS A 1 39  ? -41.79324 25.24079 -4.32336  1.000 65.90000  ? 19  LYS A CB  1 
ATOM   107  C  CG  . LYS A 1 39  ? -40.75907 24.29090 -3.79294  1.000 71.07000  ? 19  LYS A CG  1 
ATOM   108  C  CD  . LYS A 1 39  ? -39.82960 25.01087 -2.84024  1.000 76.84000  ? 19  LYS A CD  1 
ATOM   109  C  CE  . LYS A 1 39  ? -39.75484 24.31793 -1.51751  1.000 79.81000  ? 19  LYS A CE  1 
ATOM   110  N  NZ  . LYS A 1 39  ? -39.57106 25.37157 -0.50685  1.000 80.94000  ? 19  LYS A NZ  1 
ATOM   111  N  N   . HIS A 1 40  ? -40.25477 26.22795 -7.60798  1.000 70.21000  ? 20  HIS A N   1 
ATOM   112  C  CA  . HIS A 1 40  ? -39.78833 25.66091 -8.86861  1.000 73.91000  ? 20  HIS A CA  1 
ATOM   113  C  C   . HIS A 1 40  ? -38.29843 25.34667 -8.78491  1.000 73.29000  ? 20  HIS A C   1 
ATOM   114  O  O   . HIS A 1 40  ? -37.52141 26.10681 -8.19468  1.000 75.48000  ? 20  HIS A O   1 
ATOM   115  C  CB  . HIS A 1 40  ? -40.06607 26.61619 -10.03668 1.000 69.82000  ? 20  HIS A CB  1 
ATOM   116  C  CG  . HIS A 1 40  ? -39.91598 25.98582 -11.39050 1.000 73.85000  ? 20  HIS A CG  1 
ATOM   117  N  ND1 . HIS A 1 40  ? -38.69230 25.63359 -11.92013 1.000 73.77000  ? 20  HIS A ND1 1 
ATOM   118  C  CD2 . HIS A 1 40  ? -40.83805 25.63847 -12.32072 1.000 74.61000  ? 20  HIS A CD2 1 
ATOM   119  C  CE1 . HIS A 1 40  ? -38.86643 25.10110 -13.11562 1.000 77.60000  ? 20  HIS A CE1 1 
ATOM   120  N  NE2 . HIS A 1 40  ? -40.15940 25.09307 -13.38456 1.000 73.72000  ? 20  HIS A NE2 1 
ATOM   121  N  N   . MET A 1 41  ? -37.90779 24.21542 -9.38256  1.000 69.93000  ? 21  MET A N   1 
ATOM   122  C  CA  . MET A 1 41  ? -36.51656 23.78111 -9.30887  1.000 74.29000  ? 21  MET A CA  1 
ATOM   123  C  C   . MET A 1 41  ? -35.58385 24.76069 -10.01732 1.000 75.98000  ? 21  MET A C   1 
ATOM   124  O  O   . MET A 1 41  ? -34.43916 24.96029 -9.59018  1.000 74.84000  ? 21  MET A O   1 
ATOM   125  C  CB  . MET A 1 41  ? -36.37421 22.38856 -9.90868  1.000 67.72000  ? 21  MET A CB  1 
ATOM   126  C  CG  . MET A 1 41  ? -36.27812 21.27760 -8.89545  1.000 72.46000  ? 21  MET A CG  1 
ATOM   127  S  SD  . MET A 1 41  ? -36.25683 19.59470 -9.57529  1.000 72.05000  ? 21  MET A SD  1 
ATOM   128  C  CE  . MET A 1 41  ? -37.54763 19.66464 -10.82093 1.000 61.47000  ? 21  MET A CE  1 
ATOM   129  N  N   . LEU A 1 42  ? -36.05136 25.38755 -11.09866 1.000 68.24000  ? 22  LEU A N   1 
ATOM   130  C  CA  . LEU A 1 42  ? -35.17915 26.29753 -11.83594 1.000 82.34000  ? 22  LEU A CA  1 
ATOM   131  C  C   . LEU A 1 42  ? -34.78697 27.51903 -11.02409 1.000 81.90000  ? 22  LEU A C   1 
ATOM   132  O  O   . LEU A 1 42  ? -33.85537 28.22248 -11.42756 1.000 78.13000  ? 22  LEU A O   1 
ATOM   133  C  CB  . LEU A 1 42  ? -35.83368 26.75414 -13.15502 1.000 37.17000  ? 22  LEU A CB  1 
ATOM   134  C  CG  . LEU A 1 42  ? -35.22356 26.05293 -14.37338 1.000 37.17000  ? 22  LEU A CG  1 
ATOM   135  C  CD1 . LEU A 1 42  ? -36.11098 26.16391 -15.63803 1.000 37.17000  ? 22  LEU A CD1 1 
ATOM   136  C  CD2 . LEU A 1 42  ? -33.83814 26.66041 -14.62994 1.000 37.17000  ? 22  LEU A CD2 1 
ATOM   137  N  N   . GLU A 1 43  ? -35.47269 27.79236 -9.90605  1.000 77.02000  ? 23  GLU A N   1 
ATOM   138  C  CA  . GLU A 1 43  ? -35.12587 28.89104 -9.00950  1.000 76.84000  ? 23  GLU A CA  1 
ATOM   139  C  C   . GLU A 1 43  ? -34.16645 28.46878 -7.90136  1.000 75.44000  ? 23  GLU A C   1 
ATOM   140  O  O   . GLU A 1 43  ? -33.64758 29.33736 -7.19127  1.000 63.59000  ? 23  GLU A O   1 
ATOM   141  C  CB  . GLU A 1 43  ? -36.39730 29.50471 -8.39376  1.000 79.65000  ? 23  GLU A CB  1 
ATOM   142  C  CG  . GLU A 1 43  ? -37.18885 30.37767 -9.35296  1.000 81.91000  ? 23  GLU A CG  1 
ATOM   143  C  CD  . GLU A 1 43  ? -38.25290 31.22757 -8.66999  1.000 90.11000  ? 23  GLU A CD  1 
ATOM   144  O  OE1 . GLU A 1 43  ? -38.34098 31.23920 -7.41854  1.000 84.14000  ? 23  GLU A OE1 1 
ATOM   145  O  OE2 . GLU A 1 43  ? -39.00185 31.91006 -9.39809  1.000 84.20000  ? 23  GLU A OE2 1 
ATOM   146  N  N   . HIS A 1 44  ? -33.91099 27.16892 -7.75405  1.000 75.54000  ? 24  HIS A N   1 
ATOM   147  C  CA  . HIS A 1 44  ? -32.96192 26.68646 -6.76078  1.000 72.25000  ? 24  HIS A CA  1 
ATOM   148  C  C   . HIS A 1 44  ? -31.57877 27.29175 -6.99436  1.000 78.40000  ? 24  HIS A C   1 
ATOM   149  O  O   . HIS A 1 44  ? -31.18032 27.56104 -8.12980  1.000 85.93000  ? 24  HIS A O   1 
ATOM   150  C  CB  . HIS A 1 44  ? -32.89556 25.16109 -6.81224  1.000 73.53000  ? 24  HIS A CB  1 
ATOM   151  C  CG  . HIS A 1 44  ? -32.21688 24.54913 -5.63384  1.000 75.99000  ? 24  HIS A CG  1 
ATOM   152  N  ND1 . HIS A 1 44  ? -30.86233 24.65515 -5.42230  1.000 78.39000  ? 24  HIS A ND1 1 
ATOM   153  C  CD2 . HIS A 1 44  ? -32.70527 23.83287 -4.59376  1.000 80.84000  ? 24  HIS A CD2 1 
ATOM   154  C  CE1 . HIS A 1 44  ? -30.54057 24.02964 -4.30289  1.000 80.16000  ? 24  HIS A CE1 1 
ATOM   155  N  NE2 . HIS A 1 44  ? -31.64121 23.52629 -3.77680  1.000 71.59000  ? 24  HIS A NE2 1 
ATOM   156  N  N   . THR A 1 45  ? -30.83998 27.52182 -5.90297  1.000 79.46000  ? 25  THR A N   1 
ATOM   157  C  CA  . THR A 1 45  ? -29.50064 28.09030 -6.05328  1.000 80.98000  ? 25  THR A CA  1 
ATOM   158  C  C   . THR A 1 45  ? -28.60303 27.16673 -6.87000  1.000 86.60000  ? 25  THR A C   1 
ATOM   159  O  O   . THR A 1 45  ? -27.66606 27.63076 -7.52698  1.000 88.96000  ? 25  THR A O   1 
ATOM   160  C  CB  . THR A 1 45  ? -28.85228 28.37059 -4.68753  1.000 82.38000  ? 25  THR A CB  1 
ATOM   161  O  OG1 . THR A 1 45  ? -28.14246 27.20991 -4.24231  1.000 86.32000  ? 25  THR A OG1 1 
ATOM   162  C  CG2 . THR A 1 45  ? -29.91488 28.71198 -3.63851  1.000 81.26000  ? 25  THR A CG2 1 
ATOM   163  N  N   . PHE A 1 46  ? -28.87881 25.86169 -6.84292  1.000 85.34000  ? 26  PHE A N   1 
ATOM   164  C  CA  . PHE A 1 46  ? -28.10811 24.90884 -7.62959  1.000 83.25000  ? 26  PHE A CA  1 
ATOM   165  C  C   . PHE A 1 46  ? -28.22728 25.21855 -9.11421  1.000 85.93000  ? 26  PHE A C   1 
ATOM   166  O  O   . PHE A 1 46  ? -27.23154 25.49516 -9.78976  1.000 87.67000  ? 26  PHE A O   1 
ATOM   167  C  CB  . PHE A 1 46  ? -28.58361 23.48085 -7.34469  1.000 79.62000  ? 26  PHE A CB  1 
ATOM   168  C  CG  . PHE A 1 46  ? -27.81355 22.43015 -8.09469  1.000 80.67000  ? 26  PHE A CG  1 
ATOM   169  C  CD1 . PHE A 1 46  ? -26.56598 22.01487 -7.65351  1.000 83.21000  ? 26  PHE A CD1 1 
ATOM   170  C  CD2 . PHE A 1 46  ? -28.31070 21.90180 -9.27754  1.000 84.21000  ? 26  PHE A CD2 1 
ATOM   171  C  CE1 . PHE A 1 46  ? -25.85070 21.06083 -8.35681  1.000 84.46000  ? 26  PHE A CE1 1 
ATOM   172  C  CE2 . PHE A 1 46  ? -27.60101 20.95672 -9.99327  1.000 77.20000  ? 26  PHE A CE2 1 
ATOM   173  C  CZ  . PHE A 1 46  ? -26.37168 20.53466 -9.53525  1.000 79.64000  ? 26  PHE A CZ  1 
ATOM   174  N  N   . TYR A 1 47  ? -29.44965 25.17870 -9.64111  1.000 83.37000  ? 27  TYR A N   1 
ATOM   175  C  CA  . TYR A 1 47  ? -29.64387 25.48566 -11.04668 1.000 84.63000  ? 27  TYR A CA  1 
ATOM   176  C  C   . TYR A 1 47  ? -29.37029 26.94790 -11.35739 1.000 91.22000  ? 27  TYR A C   1 
ATOM   177  O  O   . TYR A 1 47  ? -29.06674 27.27498 -12.50926 1.000 89.77000  ? 27  TYR A O   1 
ATOM   178  C  CB  . TYR A 1 47  ? -31.05973 25.11010 -11.46732 1.000 86.35000  ? 27  TYR A CB  1 
ATOM   179  C  CG  . TYR A 1 47  ? -31.24593 23.63216 -11.68716 1.000 87.93000  ? 27  TYR A CG  1 
ATOM   180  C  CD1 . TYR A 1 47  ? -30.16806 22.81093 -11.98355 1.000 92.75000  ? 27  TYR A CD1 1 
ATOM   181  C  CD2 . TYR A 1 47  ? -32.49829 23.05344 -11.59472 1.000 79.24000  ? 27  TYR A CD2 1 
ATOM   182  C  CE1 . TYR A 1 47  ? -30.34248 21.44615 -12.19096 1.000 86.92000  ? 27  TYR A CE1 1 
ATOM   183  C  CE2 . TYR A 1 47  ? -32.68139 21.69859 -11.79774 1.000 82.73000  ? 27  TYR A CE2 1 
ATOM   184  C  CZ  . TYR A 1 47  ? -31.60480 20.89865 -12.09383 1.000 85.95000  ? 27  TYR A CZ  1 
ATOM   185  O  OH  . TYR A 1 47  ? -31.80360 19.54814 -12.28613 1.000 85.48000  ? 27  TYR A OH  1 
ATOM   186  N  N   . VAL A 1 48  ? -29.48016 27.83537 -10.36699 1.000 91.29000  ? 28  VAL A N   1 
ATOM   187  C  CA  . VAL A 1 48  ? -29.01039 29.20680 -10.55268 1.000 91.52000  ? 28  VAL A CA  1 
ATOM   188  C  C   . VAL A 1 48  ? -27.54439 29.19175 -10.97097 1.000 91.20000  ? 28  VAL A C   1 
ATOM   189  O  O   . VAL A 1 48  ? -27.19385 29.57151 -12.09679 1.000 88.72000  ? 28  VAL A O   1 
ATOM   190  C  CB  . VAL A 1 48  ? -29.22445 30.03541 -9.27411  1.000 85.59000  ? 28  VAL A CB  1 
ATOM   191  N  N   . LYS A 1 49  ? -26.67137 28.70655 -10.07569 1.000 89.06000  ? 29  LYS A N   1 
ATOM   192  C  CA  . LYS A 1 49  ? -25.24388 28.62836 -10.38244 1.000 90.46000  ? 29  LYS A CA  1 
ATOM   193  C  C   . LYS A 1 49  ? -25.00036 27.95099 -11.72930 1.000 93.18000  ? 29  LYS A C   1 
ATOM   194  O  O   . LYS A 1 49  ? -24.14352 28.38661 -12.50652 1.000 96.74000  ? 29  LYS A O   1 
ATOM   195  C  CB  . LYS A 1 49  ? -24.50421 27.88725 -9.26426  1.000 87.68000  ? 29  LYS A CB  1 
ATOM   196  C  CG  . LYS A 1 49  ? -24.42144 28.64759 -7.94324  1.000 89.53000  ? 29  LYS A CG  1 
ATOM   197  C  CD  . LYS A 1 49  ? -23.06470 28.48065 -7.25392  1.000 86.13000  ? 29  LYS A CD  1 
ATOM   198  C  CE  . LYS A 1 49  ? -23.10901 27.40332 -6.17230  1.000 87.35000  ? 29  LYS A CE  1 
ATOM   199  N  N   . TRP A 1 50  ? -25.76201 26.89487 -12.03144 1.000 90.95000  ? 30  TRP A N   1 
ATOM   200  C  CA  . TRP A 1 50  ? -25.61008 26.21440 -13.31469 1.000 90.25000  ? 30  TRP A CA  1 
ATOM   201  C  C   . TRP A 1 50  ? -25.99239 27.13219 -14.46635 1.000 89.70000  ? 30  TRP A C   1 
ATOM   202  O  O   . TRP A 1 50  ? -25.31186 27.14982 -15.49479 1.000 93.01000  ? 30  TRP A O   1 
ATOM   203  C  CB  . TRP A 1 50  ? -26.44571 24.92708 -13.31895 1.000 92.59000  ? 30  TRP A CB  1 
ATOM   204  C  CG  . TRP A 1 50  ? -26.55907 24.13915 -14.64264 1.000 90.27000  ? 30  TRP A CG  1 
ATOM   205  C  CD1 . TRP A 1 50  ? -26.76831 24.63846 -15.90234 1.000 90.07000  ? 30  TRP A CD1 1 
ATOM   206  C  CD2 . TRP A 1 50  ? -26.51109 22.71001 -14.79187 1.000 90.39000  ? 30  TRP A CD2 1 
ATOM   207  N  NE1 . TRP A 1 50  ? -26.83303 23.61723 -16.82284 1.000 89.33000  ? 30  TRP A NE1 1 
ATOM   208  C  CE2 . TRP A 1 50  ? -26.67837 22.42437 -16.17012 1.000 85.99000  ? 30  TRP A CE2 1 
ATOM   209  C  CE3 . TRP A 1 50  ? -26.33651 21.64509 -13.89533 1.000 80.28000  ? 30  TRP A CE3 1 
ATOM   210  C  CZ2 . TRP A 1 50  ? -26.67901 21.12233 -16.66949 1.000 83.97000  ? 30  TRP A CZ2 1 
ATOM   211  C  CZ3 . TRP A 1 50  ? -26.34093 20.35110 -14.38940 1.000 90.20000  ? 30  TRP A CZ3 1 
ATOM   212  C  CH2 . TRP A 1 50  ? -26.51006 20.10027 -15.76776 1.000 87.16000  ? 30  TRP A CH2 1 
ATOM   213  N  N   . SER A 1 51  ? -27.07731 27.89938 -14.31350 1.000 93.45000  ? 31  SER A N   1 
ATOM   214  C  CA  . SER A 1 51  ? -27.49584 28.82346 -15.36825 1.000 97.36000  ? 31  SER A CA  1 
ATOM   215  C  C   . SER A 1 51  ? -26.40369 29.83758 -15.67082 1.000 97.89000  ? 31  SER A C   1 
ATOM   216  O  O   . SER A 1 51  ? -26.13360 30.14504 -16.83807 1.000 88.25000  ? 31  SER A O   1 
ATOM   217  C  CB  . SER A 1 51  ? -28.78592 29.54055 -14.96043 1.000 90.07000  ? 31  SER A CB  1 
ATOM   218  N  N   . LYS A 1 52  ? -25.76946 30.36446 -14.62447 1.000 96.19000  ? 32  LYS A N   1 
ATOM   219  C  CA  . LYS A 1 52  ? -24.63081 31.26364 -14.72323 1.000 98.32000  ? 32  LYS A CA  1 
ATOM   220  C  C   . LYS A 1 52  ? -23.29793 30.52249 -14.78360 1.000 98.01000  ? 32  LYS A C   1 
ATOM   221  O  O   . LYS A 1 52  ? -22.24499 31.14792 -14.62512 1.000 97.21000  ? 32  LYS A O   1 
ATOM   222  C  CB  . LYS A 1 52  ? -24.63490 32.23561 -13.53642 1.000 31.63000  ? 32  LYS A CB  1 
ATOM   223  N  N   . GLY A 1 53  ? -23.32093 29.20591 -14.97221 1.000 96.34000  ? 33  GLY A N   1 
ATOM   224  C  CA  . GLY A 1 53  ? -22.12100 28.43203 -15.21113 1.000 93.73000  ? 33  GLY A CA  1 
ATOM   225  C  C   . GLY A 1 53  ? -21.15805 28.30929 -14.05653 1.000 92.85000  ? 33  GLY A C   1 
ATOM   226  O  O   . GLY A 1 53  ? -20.12149 27.65567 -14.21338 1.000 92.46000  ? 33  GLY A O   1 
ATOM   227  N  N   . GLU A 1 54  ? -21.45654 28.91000 -12.90537 1.000 91.74000  ? 34  GLU A N   1 
ATOM   228  C  CA  . GLU A 1 54  ? -20.60145 28.79909 -11.72870 1.000 84.55000  ? 34  GLU A CA  1 
ATOM   229  C  C   . GLU A 1 54  ? -20.91041 27.51540 -10.95352 1.000 91.96000  ? 34  GLU A C   1 
ATOM   230  O  O   . GLU A 1 54  ? -21.35898 27.53305 -9.81054  1.000 95.54000  ? 34  GLU A O   1 
ATOM   231  N  N   . LEU A 1 55  ? -20.66928 26.38035 -11.60573 1.000 91.60000  ? 35  LEU A N   1 
ATOM   232  C  CA  . LEU A 1 55  ? -20.69245 25.08323 -10.94442 1.000 90.40000  ? 35  LEU A CA  1 
ATOM   233  C  C   . LEU A 1 55  ? -19.47268 24.28989 -11.39289 1.000 93.50000  ? 35  LEU A C   1 
ATOM   234  O  O   . LEU A 1 55  ? -18.93839 24.52129 -12.48100 1.000 96.67000  ? 35  LEU A O   1 
ATOM   235  C  CB  . LEU A 1 55  ? -21.98011 24.31225 -11.24858 1.000 95.72000  ? 35  LEU A CB  1 
ATOM   236  C  CG  . LEU A 1 55  ? -22.96252 24.11048 -10.09357 1.000 90.18000  ? 35  LEU A CG  1 
ATOM   237  N  N   . THR A 1 56  ? -19.02219 23.36217 -10.54639 1.000 93.85000  ? 36  THR A N   1 
ATOM   238  C  CA  . THR A 1 56  ? -17.77737 22.64494 -10.79134 1.000 91.03000  ? 36  THR A CA  1 
ATOM   239  C  C   . THR A 1 56  ? -18.04172 21.22860 -11.27330 1.000 96.20000  ? 36  THR A C   1 
ATOM   240  O  O   . THR A 1 56  ? -19.01420 20.58676 -10.86851 1.000 97.96000  ? 36  THR A O   1 
ATOM   241  C  CB  . THR A 1 56  ? -16.89708 22.60171 -9.53810  1.000 31.63000  ? 36  THR A CB  1 
ATOM   242  C  CG2 . THR A 1 56  ? -17.16275 21.30488 -8.65447  1.000 31.63000  ? 36  THR A CG2 1 
ATOM   243  N  N   . LYS A 1 57  ? -17.14596 20.74364 -12.13993 1.000 90.44000  ? 37  LYS A N   1 
ATOM   244  C  CA  . LYS A 1 57  ? -17.31998 19.41975 -12.73228 1.000 92.38000  ? 37  LYS A CA  1 
ATOM   245  C  C   . LYS A 1 57  ? -17.35799 18.32412 -11.67117 1.000 92.57000  ? 37  LYS A C   1 
ATOM   246  O  O   . LYS A 1 57  ? -18.00286 17.28683 -11.87664 1.000 90.73000  ? 37  LYS A O   1 
ATOM   247  C  CB  . LYS A 1 57  ? -16.21007 19.14173 -13.75144 1.000 89.42000  ? 37  LYS A CB  1 
ATOM   248  N  N   . GLU A 1 58  ? -16.68741 18.53155 -10.53086 1.000 91.77000  ? 38  GLU A N   1 
ATOM   249  C  CA  . GLU A 1 58  ? -16.78040 17.54868 -9.45936  1.000 95.42000  ? 38  GLU A CA  1 
ATOM   250  C  C   . GLU A 1 58  ? -18.20419 17.46552 -8.92596  1.000 92.60000  ? 38  GLU A C   1 
ATOM   251  O  O   . GLU A 1 58  ? -18.66001 16.38506 -8.52381  1.000 87.74000  ? 38  GLU A O   1 
ATOM   252  C  CB  . GLU A 1 58  ? -15.79341 17.89116 -8.34202  1.000 92.60000  ? 38  GLU A CB  1 
ATOM   253  N  N   . GLN A 1 59  ? -18.92296 18.59152 -8.94807  1.000 93.15000  ? 39  GLN A N   1 
ATOM   254  C  CA  . GLN A 1 59  ? -20.30653 18.62477 -8.48243  1.000 92.90000  ? 39  GLN A CA  1 
ATOM   255  C  C   . GLN A 1 59  ? -21.23631 17.94348 -9.47873  1.000 92.32000  ? 39  GLN A C   1 
ATOM   256  O  O   . GLN A 1 59  ? -22.13288 17.18216 -9.08668  1.000 87.91000  ? 39  GLN A O   1 
ATOM   257  C  CB  . GLN A 1 59  ? -20.75175 20.07125 -8.26217  1.000 93.40000  ? 39  GLN A CB  1 
ATOM   258  C  CG  . GLN A 1 59  ? -20.35864 20.69696 -6.93859  1.000 90.23000  ? 39  GLN A CG  1 
ATOM   259  C  CD  . GLN A 1 59  ? -20.62334 22.18698 -6.93509  1.000 95.68000  ? 39  GLN A CD  1 
ATOM   260  O  OE1 . GLN A 1 59  ? -20.33362 22.87318 -7.91544  1.000 99.29000  ? 39  GLN A OE1 1 
ATOM   261  N  NE2 . GLN A 1 59  ? -21.18829 22.69610 -5.84142  1.000 86.63000  ? 39  GLN A NE2 1 
ATOM   262  N  N   . LEU A 1 60  ? -21.04423 18.21948 -10.77620 1.000 90.40000  ? 40  LEU A N   1 
ATOM   263  C  CA  . LEU A 1 60  ? -21.88570 17.60900 -11.80274 1.000 84.51000  ? 40  LEU A CA  1 
ATOM   264  C  C   . LEU A 1 60  ? -21.76273 16.09133 -11.78503 1.000 85.12000  ? 40  LEU A C   1 
ATOM   265  O  O   . LEU A 1 60  ? -22.75071 15.37742 -11.98873 1.000 86.51000  ? 40  LEU A O   1 
ATOM   266  C  CB  . LEU A 1 60  ? -21.52737 18.16139 -13.18541 1.000 87.73000  ? 40  LEU A CB  1 
ATOM   267  C  CG  . LEU A 1 60  ? -21.62751 19.66817 -13.42039 1.000 88.18000  ? 40  LEU A CG  1 
ATOM   268  N  N   . GLN A 1 61  ? -20.55805 15.57825 -11.53964 1.000 86.51000  ? 41  GLN A N   1 
ATOM   269  C  CA  . GLN A 1 61  ? -20.39783 14.13611 -11.40506 1.000 83.25000  ? 41  GLN A CA  1 
ATOM   270  C  C   . GLN A 1 61  ? -21.23393 13.60394 -10.25049 1.000 79.94000  ? 41  GLN A C   1 
ATOM   271  O  O   . GLN A 1 61  ? -21.86458 12.54707 -10.36501 1.000 73.34000  ? 41  GLN A O   1 
ATOM   272  C  CB  . GLN A 1 61  ? -18.92178 13.79402 -11.21253 1.000 88.63000  ? 41  GLN A CB  1 
ATOM   273  C  CG  . GLN A 1 61  ? -18.07158 14.15121 -12.42964 1.000 97.67000  ? 41  GLN A CG  1 
ATOM   274  C  CD  . GLN A 1 61  ? -16.65239 13.62799 -12.33827 1.000 101.89000 ? 41  GLN A CD  1 
ATOM   275  O  OE1 . GLN A 1 61  ? -16.03856 13.62756 -11.26341 1.000 98.47000  ? 41  GLN A OE1 1 
ATOM   276  N  NE2 . GLN A 1 61  ? -16.09833 13.23241 -13.48703 1.000 98.66000  ? 41  GLN A NE2 1 
ATOM   277  N  N   . ALA A 1 62  ? -21.27235 14.33790 -9.13831  1.000 82.01000  ? 42  ALA A N   1 
ATOM   278  C  CA  . ALA A 1 62  ? -22.03942 13.89225 -7.98123  1.000 73.77000  ? 42  ALA A CA  1 
ATOM   279  C  C   . ALA A 1 62  ? -23.52965 13.91124 -8.28042  1.000 78.74000  ? 42  ALA A C   1 
ATOM   280  O  O   . ALA A 1 62  ? -24.24472 12.94406 -7.99080  1.000 65.02000  ? 42  ALA A O   1 
ATOM   281  C  CB  . ALA A 1 62  ? -21.72211 14.77477 -6.77041  1.000 31.63000  ? 42  ALA A CB  1 
ATOM   282  N  N   . TYR A 1 63  ? -24.01359 15.02266 -8.83858  1.000 80.10000  ? 43  TYR A N   1 
ATOM   283  C  CA  . TYR A 1 63  ? -25.39320 15.11408 -9.30334  1.000 76.32000  ? 43  TYR A CA  1 
ATOM   284  C  C   . TYR A 1 63  ? -25.73702 13.91607 -10.17133 1.000 76.98000  ? 43  TYR A C   1 
ATOM   285  O  O   . TYR A 1 63  ? -26.58522 13.08530 -9.82360  1.000 75.21000  ? 43  TYR A O   1 
ATOM   286  C  CB  . TYR A 1 63  ? -25.57252 16.43779 -10.06877 1.000 76.58000  ? 43  TYR A CB  1 
ATOM   287  C  CG  . TYR A 1 63  ? -26.88249 16.67493 -10.81282 1.000 80.00000  ? 43  TYR A CG  1 
ATOM   288  C  CD1 . TYR A 1 63  ? -27.14076 16.07914 -12.03087 1.000 83.21000  ? 43  TYR A CD1 1 
ATOM   289  C  CD2 . TYR A 1 63  ? -27.85969 17.51005 -10.28818 1.000 79.83000  ? 43  TYR A CD2 1 
ATOM   290  C  CE1 . TYR A 1 63  ? -28.33888 16.32115 -12.71162 1.000 79.97000  ? 43  TYR A CE1 1 
ATOM   291  C  CE2 . TYR A 1 63  ? -29.05288 17.74238 -10.95072 1.000 83.08000  ? 43  TYR A CE2 1 
ATOM   292  C  CZ  . TYR A 1 63  ? -29.28490 17.14495 -12.16131 1.000 80.66000  ? 43  TYR A CZ  1 
ATOM   293  O  OH  . TYR A 1 63  ? -30.46396 17.37150 -12.82639 1.000 80.44000  ? 43  TYR A OH  1 
ATOM   294  N  N   . ALA A 1 64  ? -25.02805 13.79489 -11.28645 1.000 80.90000  ? 44  ALA A N   1 
ATOM   295  C  CA  . ALA A 1 64  ? -25.28334 12.73291 -12.24029 1.000 70.98000  ? 44  ALA A CA  1 
ATOM   296  C  C   . ALA A 1 64  ? -25.22558 11.36167 -11.57940 1.000 67.68000  ? 44  ALA A C   1 
ATOM   297  O  O   . ALA A 1 64  ? -26.10785 10.52536 -11.79352 1.000 78.14000  ? 44  ALA A O   1 
ATOM   298  C  CB  . ALA A 1 64  ? -24.26988 12.85416 -13.37050 1.000 31.63000  ? 44  ALA A CB  1 
ATOM   299  N  N   . LYS A 1 65  ? -24.18883 11.10846 -10.77752 1.000 68.60000  ? 45  LYS A N   1 
ATOM   300  C  CA  . LYS A 1 65  ? -24.08959 9.83224  -10.07022 1.000 72.00000  ? 45  LYS A CA  1 
ATOM   301  C  C   . LYS A 1 65  ? -25.32187 9.60239  -9.19802  1.000 75.31000  ? 45  LYS A C   1 
ATOM   302  O  O   . LYS A 1 65  ? -25.88323 8.50303  -9.16456  1.000 77.50000  ? 45  LYS A O   1 
ATOM   303  C  CB  . LYS A 1 65  ? -22.80544 9.79707  -9.21017  0.498 31.63000  ? 45  LYS A CB  1 
ATOM   304  C  CG  . LYS A 1 65  ? -21.51257 9.28664  -9.88748  0.646 31.63000  ? 45  LYS A CG  1 
ATOM   305  C  CD  . LYS A 1 65  ? -20.23144 10.11597 -9.54488  0.582 31.63000  ? 45  LYS A CD  1 
ATOM   306  C  CE  . LYS A 1 65  ? -19.57786 9.76161  -8.16791  0.774 31.63000  ? 45  LYS A CE  1 
ATOM   307  N  N   . ASP A 1 66  ? -25.76738 10.64172 -8.49753  1.000 72.66000  ? 46  ASP A N   1 
ATOM   308  C  CA  . ASP A 1 66  ? -26.80461 10.47710 -7.49007  1.000 76.99000  ? 46  ASP A CA  1 
ATOM   309  C  C   . ASP A 1 66  ? -28.19664 10.40704 -8.09844  1.000 73.73000  ? 46  ASP A C   1 
ATOM   310  O  O   . ASP A 1 66  ? -29.07904 9.75818  -7.52663  1.000 70.81000  ? 46  ASP A O   1 
ATOM   311  C  CB  . ASP A 1 66  ? -26.72484 11.62838 -6.48377  1.000 75.75000  ? 46  ASP A CB  1 
ATOM   312  C  CG  . ASP A 1 66  ? -27.01312 11.19819 -5.06581  1.000 76.98000  ? 46  ASP A CG  1 
ATOM   313  O  OD1 . ASP A 1 66  ? -27.02835 9.97620  -4.78287  1.000 85.30000  ? 46  ASP A OD1 1 
ATOM   314  O  OD2 . ASP A 1 66  ? -27.21177 12.10219 -4.22363  1.000 78.13000  ? 46  ASP A OD2 1 
ATOM   315  N  N   . TYR A 1 67  ? -28.41930 11.07375 -9.23477  1.000 66.16000  ? 47  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 67  ? -29.73410 11.03272 -9.85372  1.000 72.89000  ? 47  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 67  ? -30.11506 9.63531  -10.31885 1.000 72.81000  ? 47  TYR A C   1 
ATOM   318  O  O   . TYR A 1 67  ? -31.29967 9.38484  -10.58328 1.000 70.01000  ? 47  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 67  ? -29.78368 11.98251 -11.03765 1.000 77.32000  ? 47  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 67  ? -31.00400 12.86777 -11.08854 1.000 78.02000  ? 47  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 67  ? -31.04409 14.09136 -10.43605 1.000 77.98000  ? 47  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 67  ? -32.12778 12.46166 -11.78340 1.000 80.41000  ? 47  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 67  ? -32.17453 14.89108 -10.49109 1.000 76.13000  ? 47  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 67  ? -33.25002 13.24821 -11.84390 1.000 88.01000  ? 47  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 67  ? -33.27295 14.46437 -11.19922 1.000 80.22000  ? 47  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 67  ? -34.42148 15.22963 -11.28930 1.000 82.62000  ? 47  TYR A OH  1 
ATOM   327  N  N   . TYR A 1 68  ? -29.13601 8.72795  -10.41482 1.000 74.25000  ? 48  TYR A N   1 
ATOM   328  C  CA  . TYR A 1 68  ? -29.35455 7.41103  -11.00820 1.000 77.03000  ? 48  TYR A CA  1 
ATOM   329  C  C   . TYR A 1 68  ? -30.51879 6.68714  -10.35447 1.000 67.39000  ? 48  TYR A C   1 
ATOM   330  O  O   . TYR A 1 68  ? -31.36586 6.11178  -11.04545 1.000 69.07000  ? 48  TYR A O   1 
ATOM   331  C  CB  . TYR A 1 68  ? -28.07334 6.57493  -10.91150 1.000 78.33000  ? 48  TYR A CB  1 
ATOM   332  C  CG  . TYR A 1 68  ? -28.00808 5.34459  -11.80847 1.000 83.68000  ? 48  TYR A CG  1 
ATOM   333  C  CD1 . TYR A 1 68  ? -28.52888 5.35095  -13.10801 1.000 79.05000  ? 48  TYR A CD1 1 
ATOM   334  C  CD2 . TYR A 1 68  ? -27.41443 4.17040  -11.34970 1.000 84.74000  ? 48  TYR A CD2 1 
ATOM   335  C  CE1 . TYR A 1 68  ? -28.46313 4.21127  -13.91428 1.000 82.44000  ? 48  TYR A CE1 1 
ATOM   336  C  CE2 . TYR A 1 68  ? -27.33947 3.03763  -12.14689 1.000 76.19000  ? 48  TYR A CE2 1 
ATOM   337  C  CZ  . TYR A 1 68  ? -27.86390 3.06152  -13.42223 1.000 86.17000  ? 48  TYR A CZ  1 
ATOM   338  O  OH  . TYR A 1 68  ? -27.78717 1.91951  -14.19092 1.000 84.67000  ? 48  TYR A OH  1 
ATOM   339  N  N   . LEU A 1 69  ? -30.58436 6.71463  -9.01927  1.000 72.75000  ? 49  LEU A N   1 
ATOM   340  C  CA  . LEU A 1 69  ? -31.61719 5.95880  -8.30852  1.000 67.15000  ? 49  LEU A CA  1 
ATOM   341  C  C   . LEU A 1 69  ? -33.00879 6.38954  -8.75046  1.000 63.47000  ? 49  LEU A C   1 
ATOM   342  O  O   . LEU A 1 69  ? -33.88365 5.54991  -9.00148  1.000 63.93000  ? 49  LEU A O   1 
ATOM   343  C  CB  . LEU A 1 69  ? -31.43963 6.13778  -6.79543  1.000 67.96000  ? 49  LEU A CB  1 
ATOM   344  C  CG  . LEU A 1 69  ? -32.48630 5.61946  -5.79658  1.000 70.56000  ? 49  LEU A CG  1 
ATOM   345  C  CD1 . LEU A 1 69  ? -32.36138 4.12969  -5.49596  1.000 59.99000  ? 49  LEU A CD1 1 
ATOM   346  N  N   . HIS A 1 70  ? -33.21260 7.70533  -8.85195  1.000 68.61000  ? 50  HIS A N   1 
ATOM   347  C  CA  . HIS A 1 70  ? -34.45623 8.27841  -9.35612  1.000 62.79000  ? 50  HIS A CA  1 
ATOM   348  C  C   . HIS A 1 70  ? -34.74728 7.81136  -10.78054 1.000 61.20000  ? 50  HIS A C   1 
ATOM   349  O  O   . HIS A 1 70  ? -35.86001 7.35592  -11.08324 1.000 61.19000  ? 50  HIS A O   1 
ATOM   350  C  CB  . HIS A 1 70  ? -34.34629 9.80177  -9.29225  1.000 64.45000  ? 50  HIS A CB  1 
ATOM   351  C  CG  . HIS A 1 70  ? -35.60910 10.52586 -9.62922  1.000 64.39000  ? 50  HIS A CG  1 
ATOM   352  N  ND1 . HIS A 1 70  ? -36.83160 10.18349 -9.09307  1.000 63.61000  ? 50  HIS A ND1 1 
ATOM   353  C  CD2 . HIS A 1 70  ? -35.83265 11.59683 -10.42824 1.000 65.36000  ? 50  HIS A CD2 1 
ATOM   354  C  CE1 . HIS A 1 70  ? -37.75764 11.00347 -9.56141  1.000 63.20000  ? 50  HIS A CE1 1 
ATOM   355  N  NE2 . HIS A 1 70  ? -37.17634 11.87167 -10.36907 1.000 67.03000  ? 50  HIS A NE2 1 
ATOM   356  N  N   . ILE A 1 71  ? -33.74633 7.91243  -11.66470 1.000 63.17000  ? 51  ILE A N   1 
ATOM   357  C  CA  . ILE A 1 71  ? -33.91682 7.52070  -13.06309 1.000 64.73000  ? 51  ILE A CA  1 
ATOM   358  C  C   . ILE A 1 71  ? -34.40475 6.08849  -13.17209 1.000 60.79000  ? 51  ILE A C   1 
ATOM   359  O  O   . ILE A 1 71  ? -35.30445 5.78598  -13.96436 1.000 62.86000  ? 51  ILE A O   1 
ATOM   360  C  CB  . ILE A 1 71  ? -32.60190 7.70602  -13.83935 1.000 37.17000  ? 51  ILE A CB  1 
ATOM   361  C  CG1 . ILE A 1 71  ? -32.13320 9.17455  -13.78711 1.000 37.17000  ? 51  ILE A CG1 1 
ATOM   362  C  CG2 . ILE A 1 71  ? -32.76977 7.18286  -15.30319 1.000 37.17000  ? 51  ILE A CG2 1 
ATOM   363  C  CD1 . ILE A 1 71  ? -32.90553 10.12967 -14.77186 1.000 37.17000  ? 51  ILE A CD1 1 
ATOM   364  N  N   . LYS A 1 72  ? -33.80391 5.18139  -12.39812 1.000 59.71000  ? 52  LYS A N   1 
ATOM   365  C  CA  . LYS A 1 72  ? -34.15456 3.77081  -12.48037 1.000 62.47000  ? 52  LYS A CA  1 
ATOM   366  C  C   . LYS A 1 72  ? -35.49586 3.49543  -11.84053 1.000 57.18000  ? 52  LYS A C   1 
ATOM   367  O  O   . LYS A 1 72  ? -36.15251 2.50467  -12.17303 1.000 61.61000  ? 52  LYS A O   1 
ATOM   368  C  CB  . LYS A 1 72  ? -33.09201 2.91573  -11.78521 1.000 58.06000  ? 52  LYS A CB  1 
ATOM   369  C  CG  . LYS A 1 72  ? -31.73728 2.83170  -12.48822 1.000 64.23000  ? 52  LYS A CG  1 
ATOM   370  C  CD  . LYS A 1 72  ? -30.60697 2.69186  -11.46888 1.000 74.47000  ? 52  LYS A CD  1 
ATOM   371  C  CE  . LYS A 1 72  ? -30.43724 1.25856  -10.99926 1.000 74.04000  ? 52  LYS A CE  1 
ATOM   372  N  N   . ALA A 1 73  ? -35.89890 4.32663  -10.88627 1.000 55.71000  ? 53  ALA A N   1 
ATOM   373  C  CA  . ALA A 1 73  ? -37.12590 4.07159  -10.15264 1.000 62.68000  ? 53  ALA A CA  1 
ATOM   374  C  C   . ALA A 1 73  ? -38.34949 4.58432  -10.88658 1.000 62.74000  ? 53  ALA A C   1 
ATOM   375  O  O   . ALA A 1 73  ? -39.44447 4.04001  -10.69872 1.000 55.80000  ? 53  ALA A O   1 
ATOM   376  C  CB  . ALA A 1 73  ? -37.04828 4.70977  -8.75144  1.000 57.95000  ? 53  ALA A CB  1 
ATOM   377  N  N   . PHE A 1 74  ? -38.17467 5.59956  -11.72858 1.000 62.66000  ? 54  PHE A N   1 
ATOM   378  C  CA  . PHE A 1 74  ? -39.32017 6.29125  -12.30398 1.000 59.37000  ? 54  PHE A CA  1 
ATOM   379  C  C   . PHE A 1 74  ? -40.31109 5.37051  -12.99451 1.000 62.16000  ? 54  PHE A C   1 
ATOM   380  O  O   . PHE A 1 74  ? -41.52205 5.59229  -12.83273 1.000 57.69000  ? 54  PHE A O   1 
ATOM   381  C  CB  . PHE A 1 74  ? -38.85007 7.40008  -13.26038 1.000 56.77000  ? 54  PHE A CB  1 
ATOM   382  C  CG  . PHE A 1 74  ? -39.83407 8.51381  -13.38094 1.000 61.19000  ? 54  PHE A CG  1 
ATOM   383  C  CD1 . PHE A 1 74  ? -40.95594 8.37762  -14.19831 1.000 60.09000  ? 54  PHE A CD1 1 
ATOM   384  C  CD2 . PHE A 1 74  ? -39.67341 9.68278  -12.64262 1.000 59.47000  ? 54  PHE A CD2 1 
ATOM   385  C  CE1 . PHE A 1 74  ? -41.88791 9.39594  -14.29399 1.000 62.12000  ? 54  PHE A CE1 1 
ATOM   386  C  CE2 . PHE A 1 74  ? -40.60762 10.70832 -12.72315 1.000 62.11000  ? 54  PHE A CE2 1 
ATOM   387  C  CZ  . PHE A 1 74  ? -41.71823 10.56964 -13.54505 1.000 64.03000  ? 54  PHE A CZ  1 
ATOM   388  N  N   . PRO A 1 75  ? -39.90317 4.36860  -13.77312 1.000 61.10000  ? 55  PRO A N   1 
ATOM   389  C  CA  . PRO A 1 75  ? -40.89437 3.42199  -14.29395 1.000 57.54000  ? 55  PRO A CA  1 
ATOM   390  C  C   . PRO A 1 75  ? -41.79100 2.83695  -13.21728 1.000 54.39000  ? 55  PRO A C   1 
ATOM   391  O  O   . PRO A 1 75  ? -43.00656 2.73018  -13.41191 1.000 59.56000  ? 55  PRO A O   1 
ATOM   392  C  CB  . PRO A 1 75  ? -40.01973 2.34713  -14.93652 1.000 57.37000  ? 55  PRO A CB  1 
ATOM   393  C  CG  . PRO A 1 75  ? -38.81551 3.04120  -15.32134 1.000 53.37000  ? 55  PRO A CG  1 
ATOM   394  C  CD  . PRO A 1 75  ? -38.57802 4.14640  -14.37243 1.000 61.17000  ? 55  PRO A CD  1 
ATOM   395  N  N   . LYS A 1 76  ? -41.21820 2.44791  -12.07982 1.000 57.95000  ? 56  LYS A N   1 
ATOM   396  C  CA  . LYS A 1 76  ? -42.02622 1.83385  -11.03232 1.000 57.99000  ? 56  LYS A CA  1 
ATOM   397  C  C   . LYS A 1 76  ? -43.10105 2.78066  -10.50993 1.000 54.41000  ? 56  LYS A C   1 
ATOM   398  O  O   . LYS A 1 76  ? -44.20278 2.33075  -10.18842 1.000 58.44000  ? 56  LYS A O   1 
ATOM   399  C  CB  . LYS A 1 76  ? -41.13660 1.35623  -9.88734  1.000 60.96000  ? 56  LYS A CB  1 
ATOM   400  C  CG  . LYS A 1 76  ? -39.90947 0.61700  -10.33752 1.000 63.10000  ? 56  LYS A CG  1 
ATOM   401  C  CD  . LYS A 1 76  ? -38.87494 0.55278  -9.21932  1.000 67.38000  ? 56  LYS A CD  1 
ATOM   402  C  CE  . LYS A 1 76  ? -39.43828 -0.12034 -7.97826  1.000 59.88000  ? 56  LYS A CE  1 
ATOM   403  N  NZ  . LYS A 1 76  ? -38.42743 -0.24723 -6.91068  1.000 62.77000  ? 56  LYS A NZ  1 
ATOM   404  N  N   . TYR A 1 77  ? -42.81375 4.08444  -10.43652 1.000 58.10000  ? 57  TYR A N   1 
ATOM   405  C  CA  . TYR A 1 77  ? -43.85139 5.04079  -10.05602 1.000 57.31000  ? 57  TYR A CA  1 
ATOM   406  C  C   . TYR A 1 77  ? -45.09133 4.86589  -10.92342 1.000 60.44000  ? 57  TYR A C   1 
ATOM   407  O  O   . TYR A 1 77  ? -46.21707 4.82893  -10.41253 1.000 53.06000  ? 57  TYR A O   1 
ATOM   408  C  CB  . TYR A 1 77  ? -43.35610 6.48297  -10.17917 1.000 50.56000  ? 57  TYR A CB  1 
ATOM   409  C  CG  . TYR A 1 77  ? -42.04209 6.84871  -9.48103  1.000 52.22000  ? 57  TYR A CG  1 
ATOM   410  C  CD1 . TYR A 1 77  ? -41.50687 6.08703  -8.44502  1.000 56.14000  ? 57  TYR A CD1 1 
ATOM   411  C  CD2 . TYR A 1 77  ? -41.34425 7.98485  -9.87611  1.000 48.33000  ? 57  TYR A CD2 1 
ATOM   412  C  CE1 . TYR A 1 77  ? -40.30872 6.46453  -7.84014  1.000 55.16000  ? 57  TYR A CE1 1 
ATOM   413  C  CE2 . TYR A 1 77  ? -40.16877 8.36138  -9.29557  1.000 54.04000  ? 57  TYR A CE2 1 
ATOM   414  C  CZ  . TYR A 1 77  ? -39.64727 7.61578  -8.27823  1.000 56.11000  ? 57  TYR A CZ  1 
ATOM   415  O  OH  . TYR A 1 77  ? -38.45134 8.05327  -7.73322  1.000 63.43000  ? 57  TYR A OH  1 
ATOM   416  N  N   . LEU A 1 78  ? -44.89872 4.73306  -12.25051 1.000 54.02000  ? 58  LEU A N   1 
ATOM   417  C  CA  . LEU A 1 78  ? -46.04309 4.65265  -13.14141 1.000 48.67000  ? 58  LEU A CA  1 
ATOM   418  C  C   . LEU A 1 78  ? -46.72296 3.31022  -13.02317 1.000 49.71000  ? 58  LEU A C   1 
ATOM   419  O  O   . LEU A 1 78  ? -47.95334 3.25327  -12.94720 1.000 51.93000  ? 58  LEU A O   1 
ATOM   420  C  CB  . LEU A 1 78  ? -45.62222 4.91564  -14.58124 1.000 53.54000  ? 58  LEU A CB  1 
ATOM   421  C  CG  . LEU A 1 78  ? -45.02061 6.30435  -14.70682 1.000 58.14000  ? 58  LEU A CG  1 
ATOM   422  C  CD1 . LEU A 1 78  ? -43.72841 6.20984  -15.48674 1.000 55.32000  ? 58  LEU A CD1 1 
ATOM   423  C  CD2 . LEU A 1 78  ? -45.99871 7.33288  -15.31702 1.000 46.52000  ? 58  LEU A CD2 1 
ATOM   424  N  N   . SER A 1 79  ? -45.95483 2.21586  -12.99919 1.000 47.90000  ? 59  SER A N   1 
ATOM   425  C  CA  . SER A 1 79  ? -46.59568 0.90621  -12.88231 1.000 53.87000  ? 59  SER A CA  1 
ATOM   426  C  C   . SER A 1 79  ? -47.39315 0.81023  -11.59224 1.000 50.86000  ? 59  SER A C   1 
ATOM   427  O  O   . SER A 1 79  ? -48.48543 0.22381  -11.57424 1.000 53.47000  ? 59  SER A O   1 
ATOM   428  C  CB  . SER A 1 79  ? -45.56803 -0.21836 -12.93547 1.000 50.06000  ? 59  SER A CB  1 
ATOM   429  O  OG  . SER A 1 79  ? -44.45573 0.07625  -12.11625 1.000 55.96000  ? 59  SER A OG  1 
ATOM   430  N  N   . ALA A 1 80  ? -46.84137 1.37306  -10.50110 1.000 53.08000  ? 60  ALA A N   1 
ATOM   431  C  CA  . ALA A 1 80  ? -47.51161 1.36986  -9.20544  1.000 58.46000  ? 60  ALA A CA  1 
ATOM   432  C  C   . ALA A 1 80  ? -48.91274 1.92738  -9.31886  1.000 57.04000  ? 60  ALA A C   1 
ATOM   433  O  O   . ALA A 1 80  ? -49.88231 1.30993  -8.86336  1.000 63.70000  ? 60  ALA A O   1 
ATOM   434  C  CB  . ALA A 1 80  ? -46.70282 2.18771  -8.19204  1.000 51.62000  ? 60  ALA A CB  1 
ATOM   435  N  N   . ILE A 1 81  ? -49.02336 3.10957  -9.92242  1.000 53.45000  ? 61  ILE A N   1 
ATOM   436  C  CA  . ILE A 1 81  ? -50.30594 3.78268  -10.05849 1.000 49.62000  ? 61  ILE A CA  1 
ATOM   437  C  C   . ILE A 1 81  ? -51.21131 2.93941  -10.93275 1.000 57.66000  ? 61  ILE A C   1 
ATOM   438  O  O   . ILE A 1 81  ? -52.31156 2.53929  -10.53290 1.000 54.36000  ? 61  ILE A O   1 
ATOM   439  C  CB  . ILE A 1 81  ? -50.10277 5.17497  -10.67803 1.000 55.95000  ? 61  ILE A CB  1 
ATOM   440  C  CG1 . ILE A 1 81  ? -49.38570 6.09678  -9.71175  1.000 51.48000  ? 61  ILE A CG1 1 
ATOM   441  C  CG2 . ILE A 1 81  ? -51.43576 5.79856  -10.99717 1.000 55.26000  ? 61  ILE A CG2 1 
ATOM   442  C  CD1 . ILE A 1 81  ? -48.96819 7.40141  -10.34158 1.000 53.85000  ? 61  ILE A CD1 1 
ATOM   443  N  N   . HIS A 1 82  ? -50.74391 2.68026  -12.15648 1.000 58.85000  ? 62  HIS A N   1 
ATOM   444  C  CA  . HIS A 1 82  ? -51.35363 1.74057  -13.07685 1.000 51.93000  ? 62  HIS A CA  1 
ATOM   445  C  C   . HIS A 1 82  ? -51.86378 0.47196  -12.40622 1.000 56.52000  ? 62  HIS A C   1 
ATOM   446  O  O   . HIS A 1 82  ? -53.01077 0.07547  -12.62138 1.000 58.85000  ? 62  HIS A O   1 
ATOM   447  C  CB  . HIS A 1 82  ? -50.31452 1.39136  -14.14417 1.000 54.11000  ? 62  HIS A CB  1 
ATOM   448  C  CG  . HIS A 1 82  ? -50.81913 0.47435  -15.20985 1.000 56.42000  ? 62  HIS A CG  1 
ATOM   449  N  ND1 . HIS A 1 82  ? -51.09697 -0.85382 -14.97537 1.000 53.72000  ? 62  HIS A ND1 1 
ATOM   450  C  CD2 . HIS A 1 82  ? -51.07821 0.69457  -16.52362 1.000 54.91000  ? 62  HIS A CD2 1 
ATOM   451  C  CE1 . HIS A 1 82  ? -51.51223 -1.41293 -16.10178 1.000 54.69000  ? 62  HIS A CE1 1 
ATOM   452  N  NE2 . HIS A 1 82  ? -51.51014 -0.49530 -17.05293 1.000 56.78000  ? 62  HIS A NE2 1 
ATOM   453  N  N   . SER A 1 83  ? -51.02766 -0.20117 -11.60860 1.000 54.11000  ? 63  SER A N   1 
ATOM   454  C  CA  . SER A 1 83  ? -51.47083 -1.45579 -10.99955 1.000 55.80000  ? 63  SER A CA  1 
ATOM   455  C  C   . SER A 1 83  ? -52.65329 -1.28341 -10.05296 1.000 58.74000  ? 63  SER A C   1 
ATOM   456  O  O   . SER A 1 83  ? -53.25095 -2.29305 -9.65818  1.000 57.87000  ? 63  SER A O   1 
ATOM   457  C  CB  . SER A 1 83  ? -50.34337 -2.13401 -10.22525 1.000 54.74000  ? 63  SER A CB  1 
ATOM   458  O  OG  . SER A 1 83  ? -50.07394 -1.45591 -9.01208  1.000 61.23000  ? 63  SER A OG  1 
ATOM   459  N  N   . ARG A 1 84  ? -53.01492 -0.05242 -9.67886  1.000 60.30000  ? 64  ARG A N   1 
ATOM   460  C  CA  . ARG A 1 84  ? -54.10000 0.16152  -8.72378  1.000 62.64000  ? 64  ARG A CA  1 
ATOM   461  C  C   . ARG A 1 84  ? -55.36602 0.68605  -9.36655  1.000 64.98000  ? 64  ARG A C   1 
ATOM   462  O  O   . ARG A 1 84  ? -56.34590 0.94736  -8.65713  1.000 59.12000  ? 64  ARG A O   1 
ATOM   463  C  CB  . ARG A 1 84  ? -53.66286 1.12167  -7.61945  1.000 60.37000  ? 64  ARG A CB  1 
ATOM   464  C  CG  . ARG A 1 84  ? -52.72899 0.48340  -6.61621  1.000 64.15000  ? 64  ARG A CG  1 
ATOM   465  C  CD  . ARG A 1 84  ? -51.84779 1.53594  -5.92410  1.000 66.75000  ? 64  ARG A CD  1 
ATOM   466  N  NE  . ARG A 1 84  ? -50.44899 1.12740  -5.95686  1.000 77.36000  ? 64  ARG A NE  1 
ATOM   467  C  CZ  . ARG A 1 84  ? -49.92398 0.19966  -5.16554  1.000 68.50000  ? 64  ARG A CZ  1 
ATOM   468  N  NH1 . ARG A 1 84  ? -50.64514 -0.40958 -4.23952  1.000 71.51000  ? 64  ARG A NH1 1 
ATOM   469  N  NH2 . ARG A 1 84  ? -48.64942 -0.14160 -5.32341  1.000 69.86000  ? 64  ARG A NH2 1 
ATOM   470  N  N   . CYS A 1 85  ? -55.38054 0.80270  -10.69032 1.000 61.50000  ? 65  CYS A N   1 
ATOM   471  C  CA  . CYS A 1 85  ? -56.31968 1.64715  -11.40152 1.000 57.71000  ? 65  CYS A CA  1 
ATOM   472  C  C   . CYS A 1 85  ? -57.29961 0.79933  -12.18899 1.000 60.36000  ? 65  CYS A C   1 
ATOM   473  O  O   . CYS A 1 85  ? -56.89418 -0.12040 -12.90333 1.000 65.36000  ? 65  CYS A O   1 
ATOM   474  C  CB  . CYS A 1 85  ? -55.56819 2.57985  -12.33736 1.000 58.78000  ? 65  CYS A CB  1 
ATOM   475  S  SG  . CYS A 1 85  ? -56.67334 3.64152  -13.21528 1.000 62.88000  ? 65  CYS A SG  1 
ATOM   476  N  N   . ASP A 1 86  ? -58.58301 1.10641  -12.06729 1.000 63.61000  ? 66  ASP A N   1 
ATOM   477  C  CA  . ASP A 1 86  ? -59.56980 0.37746  -12.83546 1.000 57.43000  ? 66  ASP A CA  1 
ATOM   478  C  C   . ASP A 1 86  ? -60.15964 1.18709  -13.99169 1.000 61.10000  ? 66  ASP A C   1 
ATOM   479  O  O   . ASP A 1 86  ? -60.89066 0.61703  -14.81099 1.000 60.91000  ? 66  ASP A O   1 
ATOM   480  C  CB  . ASP A 1 86  ? -60.67927 -0.13307 -11.91517 1.000 61.63000  ? 66  ASP A CB  1 
ATOM   481  C  CG  . ASP A 1 86  ? -60.23502 -1.33820 -11.08439 1.000 65.95000  ? 66  ASP A CG  1 
ATOM   482  O  OD1 . ASP A 1 86  ? -59.56609 -2.21845 -11.66268 1.000 67.87000  ? 66  ASP A OD1 1 
ATOM   483  O  OD2 . ASP A 1 86  ? -60.56470 -1.40880 -9.87059  1.000 65.26000  ? 66  ASP A OD2 1 
ATOM   484  N  N   . ASP A 1 87  ? -59.83543 2.47548  -14.10317 1.000 54.21000  ? 67  ASP A N   1 
ATOM   485  C  CA  . ASP A 1 87  ? -60.22362 3.29277  -15.25131 1.000 55.77000  ? 67  ASP A CA  1 
ATOM   486  C  C   . ASP A 1 87  ? -59.43458 2.81517  -16.46114 1.000 55.31000  ? 67  ASP A C   1 
ATOM   487  O  O   . ASP A 1 87  ? -58.27934 3.19057  -16.64205 1.000 56.88000  ? 67  ASP A O   1 
ATOM   488  C  CB  . ASP A 1 87  ? -59.94478 4.75726  -14.94514 1.000 59.73000  ? 67  ASP A CB  1 
ATOM   489  C  CG  . ASP A 1 87  ? -60.57456 5.71042  -15.94060 1.000 65.29000  ? 67  ASP A CG  1 
ATOM   490  O  OD1 . ASP A 1 87  ? -60.66931 5.38229  -17.14298 1.000 70.71000  ? 67  ASP A OD1 1 
ATOM   491  O  OD2 . ASP A 1 87  ? -60.96799 6.81288  -15.52234 1.000 67.87000  ? 67  ASP A OD2 1 
ATOM   492  N  N   . LEU A 1 88  ? -60.04674 1.97717  -17.29574 1.000 60.90000  ? 68  LEU A N   1 
ATOM   493  C  CA  . LEU A 1 88  ? -59.29801 1.36798  -18.39625 1.000 57.74000  ? 68  LEU A CA  1 
ATOM   494  C  C   . LEU A 1 88  ? -58.69153 2.42446  -19.31363 1.000 58.55000  ? 68  LEU A C   1 
ATOM   495  O  O   . LEU A 1 88  ? -57.56170 2.27170  -19.78927 1.000 64.63000  ? 68  LEU A O   1 
ATOM   496  C  CB  . LEU A 1 88  ? -60.19774 0.41417  -19.17709 1.000 58.58000  ? 68  LEU A CB  1 
ATOM   497  C  CG  . LEU A 1 88  ? -60.22880 -0.99316 -18.58368 1.000 62.40000  ? 68  LEU A CG  1 
ATOM   498  N  N   . GLU A 1 89  ? -59.40486 3.52328  -19.54632 1.000 65.83000  ? 69  GLU A N   1 
ATOM   499  C  CA  . GLU A 1 89  ? -58.86058 4.57555  -20.39751 1.000 55.11000  ? 69  GLU A CA  1 
ATOM   500  C  C   . GLU A 1 89  ? -57.69888 5.28166  -19.71412 1.000 58.84000  ? 69  GLU A C   1 
ATOM   501  O  O   . GLU A 1 89  ? -56.74648 5.70812  -20.37356 1.000 64.92000  ? 69  GLU A O   1 
ATOM   502  C  CB  . GLU A 1 89  ? -59.96537 5.56491  -20.75661 1.000 69.01000  ? 69  GLU A CB  1 
ATOM   503  C  CG  . GLU A 1 89  ? -59.73982 6.32583  -22.04416 1.000 77.43000  ? 69  GLU A CG  1 
ATOM   504  C  CD  . GLU A 1 89  ? -59.49786 5.41004  -23.23961 1.000 82.67000  ? 69  GLU A CD  1 
ATOM   505  O  OE1 . GLU A 1 89  ? -60.38499 4.57643  -23.55142 1.000 78.10000  ? 69  GLU A OE1 1 
ATOM   506  O  OE2 . GLU A 1 89  ? -58.42714 5.53643  -23.87822 1.000 84.00000  ? 69  GLU A OE2 1 
ATOM   507  N  N   . ALA A 1 90  ? -57.75869 5.40728  -18.38664 1.000 62.22000  ? 70  ALA A N   1 
ATOM   508  C  CA  . ALA A 1 90  ? -56.67925 6.05105  -17.64518 1.000 60.79000  ? 70  ALA A CA  1 
ATOM   509  C  C   . ALA A 1 90  ? -55.40281 5.23228  -17.70346 1.000 55.17000  ? 70  ALA A C   1 
ATOM   510  O  O   . ALA A 1 90  ? -54.30453 5.79473  -17.70930 1.000 57.20000  ? 70  ALA A O   1 
ATOM   511  C  CB  . ALA A 1 90  ? -57.09208 6.25288  -16.18770 1.000 57.98000  ? 70  ALA A CB  1 
ATOM   512  N  N   . ARG A 1 91  ? -55.52840 3.90692  -17.73875 1.000 49.80000  ? 71  ARG A N   1 
ATOM   513  C  CA  . ARG A 1 91  ? -54.34946 3.04706  -17.76565 1.000 61.44000  ? 71  ARG A CA  1 
ATOM   514  C  C   . ARG A 1 91  ? -53.62699 3.12806  -19.11716 1.000 60.15000  ? 71  ARG A C   1 
ATOM   515  O  O   . ARG A 1 91  ? -52.38923 3.08622  -19.16994 1.000 54.36000  ? 71  ARG A O   1 
ATOM   516  C  CB  . ARG A 1 91  ? -54.76142 1.60683  -17.43964 1.000 57.92000  ? 71  ARG A CB  1 
ATOM   517  C  CG  . ARG A 1 91  ? -55.19416 1.40438  -16.00123 1.000 60.55000  ? 71  ARG A CG  1 
ATOM   518  C  CD  . ARG A 1 91  ? -54.94167 -0.00535 -15.48698 1.000 57.33000  ? 71  ARG A CD  1 
ATOM   519  N  NE  . ARG A 1 91  ? -55.40233 -1.05912 -16.38562 1.000 54.81000  ? 71  ARG A NE  1 
ATOM   520  C  CZ  . ARG A 1 91  ? -56.39042 -1.90540 -16.12438 1.000 61.58000  ? 71  ARG A CZ  1 
ATOM   521  N  NH1 . ARG A 1 91  ? -57.08340 -1.83591 -15.00534 1.000 62.22000  ? 71  ARG A NH1 1 
ATOM   522  N  NH2 . ARG A 1 91  ? -56.69096 -2.84709 -17.01235 1.000 57.07000  ? 71  ARG A NH2 1 
ATOM   523  N  N   . LYS A 1 92  ? -54.37545 3.25931  -20.21773 1.000 56.37000  ? 72  LYS A N   1 
ATOM   524  C  CA  . LYS A 1 92  ? -53.72633 3.37481  -21.52304 1.000 58.70000  ? 72  LYS A CA  1 
ATOM   525  C  C   . LYS A 1 92  ? -52.75335 4.53511  -21.53580 1.000 55.18000  ? 72  LYS A C   1 
ATOM   526  O  O   . LYS A 1 92  ? -51.62906 4.39733  -22.02328 1.000 65.35000  ? 72  LYS A O   1 
ATOM   527  C  CB  . LYS A 1 92  ? -54.76426 3.53737  -22.63812 1.000 56.79000  ? 72  LYS A CB  1 
ATOM   528  C  CG  . LYS A 1 92  ? -55.25981 2.22605  -23.21143 1.000 57.12000  ? 72  LYS A CG  1 
ATOM   529  C  CD  . LYS A 1 92  ? -56.69990 2.33098  -23.68706 1.000 75.42000  ? 72  LYS A CD  1 
ATOM   530  N  N   . LEU A 1 93  ? -53.14386 5.66452  -20.93748 1.000 57.03000  ? 73  LEU A N   1 
ATOM   531  C  CA  . LEU A 1 93  ? -52.28879 6.84579  -20.92599 1.000 54.23000  ? 73  LEU A CA  1 
ATOM   532  C  C   . LEU A 1 93  ? -51.05715 6.64265  -20.06076 1.000 56.38000  ? 73  LEU A C   1 
ATOM   533  O  O   . LEU A 1 93  ? -49.98573 7.17246  -20.36907 1.000 60.08000  ? 73  LEU A O   1 
ATOM   534  C  CB  . LEU A 1 93  ? -53.06327 8.05356  -20.41562 1.000 56.15000  ? 73  LEU A CB  1 
ATOM   535  C  CG  . LEU A 1 93  ? -54.21570 8.65171  -21.19758 1.000 64.39000  ? 73  LEU A CG  1 
ATOM   536  C  CD1 . LEU A 1 93  ? -54.91817 9.66649  -20.33463 1.000 60.83000  ? 73  LEU A CD1 1 
ATOM   537  C  CD2 . LEU A 1 93  ? -53.73022 9.27062  -22.50758 1.000 66.39000  ? 73  LEU A CD2 1 
ATOM   538  N  N   . LEU A 1 94  ? -51.20642 5.93308  -18.93837 1.000 61.25000  ? 74  LEU A N   1 
ATOM   539  C  CA  . LEU A 1 94  ? -50.06940 5.67052  -18.06259 1.000 58.92000  ? 74  LEU A CA  1 
ATOM   540  C  C   . LEU A 1 94  ? -49.08355 4.72762  -18.73711 1.000 56.85000  ? 74  LEU A C   1 
ATOM   541  O  O   . LEU A 1 94  ? -47.87232 4.95922  -18.73195 1.000 58.71000  ? 74  LEU A O   1 
ATOM   542  C  CB  . LEU A 1 94  ? -50.55575 5.08406  -16.73257 1.000 59.41000  ? 74  LEU A CB  1 
ATOM   543  C  CG  . LEU A 1 94  ? -51.31325 5.96456  -15.73723 1.000 59.62000  ? 74  LEU A CG  1 
ATOM   544  C  CD1 . LEU A 1 94  ? -52.20023 5.11530  -14.87066 1.000 54.64000  ? 74  LEU A CD1 1 
ATOM   545  C  CD2 . LEU A 1 94  ? -50.33399 6.73402  -14.88258 1.000 54.24000  ? 74  LEU A CD2 1 
ATOM   546  N  N   . LEU A 1 95  ? -49.59492 3.64802  -19.30685 1.000 57.49000  ? 75  LEU A N   1 
ATOM   547  C  CA  . LEU A 1 95  ? -48.78256 2.76306  -20.12991 1.000 59.21000  ? 75  LEU A CA  1 
ATOM   548  C  C   . LEU A 1 95  ? -48.02198 3.52401  -21.23137 1.000 61.31000  ? 75  LEU A C   1 
ATOM   549  O  O   . LEU A 1 95  ? -46.85314 3.22497  -21.50714 1.000 60.50000  ? 75  LEU A O   1 
ATOM   550  C  CB  . LEU A 1 95  ? -49.70430 1.69715  -20.71609 1.000 60.12000  ? 75  LEU A CB  1 
ATOM   551  C  CG  . LEU A 1 95  ? -49.12988 0.58707  -21.57252 1.000 58.84000  ? 75  LEU A CG  1 
ATOM   552  C  CD1 . LEU A 1 95  ? -47.90168 -0.01932 -20.93074 1.000 53.84000  ? 75  LEU A CD1 1 
ATOM   553  C  CD2 . LEU A 1 95  ? -50.19946 -0.46297 -21.88136 1.000 52.98000  ? 75  LEU A CD2 1 
ATOM   554  N  N   . ASP A 1 96  ? -48.66014 4.53049  -21.84970 1.000 59.43000  ? 76  ASP A N   1 
ATOM   555  C  CA  . ASP A 1 96  ? -47.98384 5.36572  -22.84456 1.000 56.50000  ? 76  ASP A CA  1 
ATOM   556  C  C   . ASP A 1 96  ? -46.76208 6.06363  -22.27684 1.000 57.82000  ? 76  ASP A C   1 
ATOM   557  O  O   . ASP A 1 96  ? -45.73130 6.16084  -22.95347 1.000 59.50000  ? 76  ASP A O   1 
ATOM   558  C  CB  . ASP A 1 96  ? -48.93626 6.42181  -23.39595 1.000 63.21000  ? 76  ASP A CB  1 
ATOM   559  C  CG  . ASP A 1 96  ? -50.04151 5.83405  -24.23205 1.000 67.64000  ? 76  ASP A CG  1 
ATOM   560  O  OD1 . ASP A 1 96  ? -49.84832 4.70547  -24.74793 1.000 70.70000  ? 76  ASP A OD1 1 
ATOM   561  O  OD2 . ASP A 1 96  ? -51.10954 6.48784  -24.33907 1.000 75.55000  ? 76  ASP A OD2 1 
ATOM   562  N  N   . ASN A 1 97  ? -46.88459 6.63219  -21.06674 1.000 58.80000  ? 77  ASN A N   1 
ATOM   563  C  CA  . ASN A 1 97  ? -45.73953 7.25242  -20.40291 1.000 60.68000  ? 77  ASN A CA  1 
ATOM   564  C  C   . ASN A 1 97  ? -44.66406 6.21515  -20.12355 1.000 57.39000  ? 77  ASN A C   1 
ATOM   565  O  O   . ASN A 1 97  ? -43.48218 6.44878  -20.37859 1.000 65.14000  ? 77  ASN A O   1 
ATOM   566  C  CB  . ASN A 1 97  ? -46.19806 7.92680  -19.10025 1.000 60.21000  ? 77  ASN A CB  1 
ATOM   567  C  CG  . ASN A 1 97  ? -45.16186 8.91783  -18.49978 1.000 59.18000  ? 77  ASN A CG  1 
ATOM   568  O  OD1 . ASN A 1 97  ? -43.94602 8.76814  -18.64111 1.000 61.95000  ? 77  ASN A OD1 1 
ATOM   569  N  ND2 . ASN A 1 97  ? -45.67207 9.93822  -17.81590 1.000 58.93000  ? 77  ASN A ND2 1 
ATOM   570  N  N   . LEU A 1 98  ? -45.06371 5.04666  -19.63666 1.000 55.46000  ? 78  LEU A N   1 
ATOM   571  C  CA  . LEU A 1 98  ? -44.09569 4.04601  -19.21043 1.000 60.38000  ? 78  LEU A CA  1 
ATOM   572  C  C   . LEU A 1 98  ? -43.35111 3.46181  -20.40206 1.000 62.96000  ? 78  LEU A C   1 
ATOM   573  O  O   . LEU A 1 98  ? -42.13600 3.22841  -20.33391 1.000 61.61000  ? 78  LEU A O   1 
ATOM   574  C  CB  . LEU A 1 98  ? -44.82244 2.97397  -18.42140 1.000 49.25000  ? 78  LEU A CB  1 
ATOM   575  C  CG  . LEU A 1 98  ? -44.05768 1.70748  -18.11151 1.000 64.16000  ? 78  LEU A CG  1 
ATOM   576  C  CD1 . LEU A 1 98  ? -42.83132 2.01435  -17.23592 1.000 50.65000  ? 78  LEU A CD1 1 
ATOM   577  C  CD2 . LEU A 1 98  ? -45.02791 0.72882  -17.45000 1.000 54.42000  ? 78  LEU A CD2 1 
ATOM   578  N  N   . MET A 1 99  ? -44.06722 3.23558  -21.50768 1.000 59.92000  ? 79  MET A N   1 
ATOM   579  C  CA  . MET A 1 99  ? -43.42587 2.89788  -22.77616 1.000 63.70000  ? 79  MET A CA  1 
ATOM   580  C  C   . MET A 1 99  ? -42.35380 3.90574  -23.12514 1.000 64.16000  ? 79  MET A C   1 
ATOM   581  O  O   . MET A 1 99  ? -41.20980 3.53924  -23.40873 1.000 61.08000  ? 79  MET A O   1 
ATOM   582  C  CB  . MET A 1 99  ? -44.45993 2.86152  -23.88952 1.000 58.94000  ? 79  MET A CB  1 
ATOM   583  C  CG  . MET A 1 99  ? -45.34335 1.68715  -23.79789 1.000 59.36000  ? 79  MET A CG  1 
ATOM   584  S  SD  . MET A 1 99  ? -46.43519 1.57201  -25.19056 1.000 73.53000  ? 79  MET A SD  1 
ATOM   585  C  CE  . MET A 1 99  ? -47.62451 0.51725  -24.49301 1.000 70.21000  ? 79  MET A CE  1 
ATOM   586  N  N   . ASP A 1 100 ? -42.71217 5.19157  -23.10828 1.000 60.31000  ? 80  ASP A N   1 
ATOM   587  C  CA  . ASP A 1 100 ? -41.73722 6.22576  -23.42100 1.000 66.42000  ? 80  ASP A CA  1 
ATOM   588  C  C   . ASP A 1 100 ? -40.53060 6.13114  -22.51154 1.000 64.47000  ? 80  ASP A C   1 
ATOM   589  O  O   . ASP A 1 100 ? -39.40624 6.41910  -22.93474 1.000 71.58000  ? 80  ASP A O   1 
ATOM   590  C  CB  . ASP A 1 100 ? -42.37150 7.61071  -23.30520 1.000 65.31000  ? 80  ASP A CB  1 
ATOM   591  C  CG  . ASP A 1 100 ? -43.32522 7.91376  -24.44282 1.000 67.30000  ? 80  ASP A CG  1 
ATOM   592  O  OD1 . ASP A 1 100 ? -43.42129 7.10666  -25.39510 1.000 77.26000  ? 80  ASP A OD1 1 
ATOM   593  O  OD2 . ASP A 1 100 ? -43.97275 8.97323  -24.38755 1.000 66.24000  ? 80  ASP A OD2 1 
ATOM   594  N  N   . GLU A 1 101 ? -40.74402 5.70062  -21.26947 1.000 64.82000  ? 81  GLU A N   1 
ATOM   595  C  CA  . GLU A 1 101 ? -39.68520 5.69983  -20.27123 1.000 60.09000  ? 81  GLU A CA  1 
ATOM   596  C  C   . GLU A 1 101 ? -38.78980 4.47424  -20.42932 1.000 59.68000  ? 81  GLU A C   1 
ATOM   597  O  O   . GLU A 1 101 ? -37.56512 4.58273  -20.33801 1.000 62.68000  ? 81  GLU A O   1 
ATOM   598  C  CB  . GLU A 1 101 ? -40.31864 5.77583  -18.86470 1.000 60.28000  ? 81  GLU A CB  1 
ATOM   599  C  CG  . GLU A 1 101 ? -39.36799 6.17121  -17.74014 1.000 62.13000  ? 81  GLU A CG  1 
ATOM   600  C  CD  . GLU A 1 101 ? -38.91169 7.62468  -17.83199 1.000 70.52000  ? 81  GLU A CD  1 
ATOM   601  O  OE1 . GLU A 1 101 ? -39.69678 8.45606  -18.33976 1.000 80.28000  ? 81  GLU A OE1 1 
ATOM   602  O  OE2 . GLU A 1 101 ? -37.77677 7.94788  -17.39684 1.000 75.24000  ? 81  GLU A OE2 1 
ATOM   603  N  N   . GLU A 1 102 ? -39.37403 3.32001  -20.71393 1.000 58.72000  ? 82  GLU A N   1 
ATOM   604  C  CA  . GLU A 1 102 ? -38.64796 2.06165  -20.62267 1.000 59.05000  ? 82  GLU A CA  1 
ATOM   605  C  C   . GLU A 1 102 ? -38.49871 1.29692  -21.93294 1.000 57.63000  ? 82  GLU A C   1 
ATOM   606  O  O   . GLU A 1 102 ? -37.45400 0.70514  -22.15694 1.000 59.47000  ? 82  GLU A O   1 
ATOM   607  C  CB  . GLU A 1 102 ? -39.31624 1.14325  -19.58273 1.000 52.15000  ? 82  GLU A CB  1 
ATOM   608  C  CG  . GLU A 1 102 ? -38.27273 0.53781  -18.64610 1.000 63.30000  ? 82  GLU A CG  1 
ATOM   609  C  CD  . GLU A 1 102 ? -38.82154 -0.20762 -17.43726 1.000 59.28000  ? 82  GLU A CD  1 
ATOM   610  O  OE1 . GLU A 1 102 ? -40.02703 -0.55523 -17.37274 1.000 54.77000  ? 82  GLU A OE1 1 
ATOM   611  O  OE2 . GLU A 1 102 ? -37.99495 -0.45442 -16.54651 1.000 57.62000  ? 82  GLU A OE2 1 
ATOM   612  N  N   . ASN A 1 103 ? -39.51204 1.25961  -22.79593 1.000 60.88000  ? 83  ASN A N   1 
ATOM   613  C  CA  . ASN A 1 103 ? -39.47074 0.37368  -23.95837 1.000 67.05000  ? 83  ASN A CA  1 
ATOM   614  C  C   . ASN A 1 103 ? -38.40499 0.80553  -24.95818 1.000 63.86000  ? 83  ASN A C   1 
ATOM   615  O  O   . ASN A 1 103 ? -38.15881 1.99946  -25.15955 1.000 61.16000  ? 83  ASN A O   1 
ATOM   616  C  CB  . ASN A 1 103 ? -40.82700 0.32483  -24.65776 1.000 60.80000  ? 83  ASN A CB  1 
ATOM   617  C  CG  . ASN A 1 103 ? -40.90485 -0.77955 -25.72105 1.000 67.18000  ? 83  ASN A CG  1 
ATOM   618  O  OD1 . ASN A 1 103 ? -40.60284 -1.94527 -25.45285 1.000 66.87000  ? 83  ASN A OD1 1 
ATOM   619  N  ND2 . ASN A 1 103 ? -41.33359 -0.41296 -26.92749 1.000 55.75000  ? 83  ASN A ND2 1 
ATOM   620  N  N   . GLY A 1 104 ? -37.76833 -0.18638 -25.58604 1.000 72.57000  ? 84  GLY A N   1 
ATOM   621  C  CA  . GLY A 1 104 ? -36.81922 0.05689  -26.65061 1.000 57.74000  ? 84  GLY A CA  1 
ATOM   622  C  C   . GLY A 1 104 ? -35.43509 0.41070  -26.13979 1.000 62.43000  ? 84  GLY A C   1 
ATOM   623  O  O   . GLY A 1 104 ? -35.10448 0.27864  -24.95871 1.000 63.74000  ? 84  GLY A O   1 
ATOM   624  N  N   . TYR A 1 105 ? -34.60526 0.86699  -27.08039 1.000 68.26000  ? 85  TYR A N   1 
ATOM   625  C  CA  . TYR A 1 105 ? -33.23201 1.28028  -26.85530 1.000 64.93000  ? 85  TYR A CA  1 
ATOM   626  C  C   . TYR A 1 105 ? -32.93195 2.43795  -27.80175 1.000 66.65000  ? 85  TYR A C   1 
ATOM   627  O  O   . TYR A 1 105 ? -33.34029 2.40073  -28.97387 1.000 77.74000  ? 85  TYR A O   1 
ATOM   628  C  CB  . TYR A 1 105 ? -32.23190 0.13659  -27.05878 1.000 64.18000  ? 85  TYR A CB  1 
ATOM   629  C  CG  . TYR A 1 105 ? -30.77801 0.48120  -26.77257 1.000 74.76000  ? 85  TYR A CG  1 
ATOM   630  C  CD1 . TYR A 1 105 ? -30.23233 0.27870  -25.50995 1.000 72.70000  ? 85  TYR A CD1 1 
ATOM   631  C  CD2 . TYR A 1 105 ? -29.93557 0.96666  -27.78334 1.000 77.27000  ? 85  TYR A CD2 1 
ATOM   632  C  CE1 . TYR A 1 105 ? -28.90319 0.58760  -25.24052 1.000 74.96000  ? 85  TYR A CE1 1 
ATOM   633  C  CE2 . TYR A 1 105 ? -28.59638 1.27990  -27.52425 1.000 78.30000  ? 85  TYR A CE2 1 
ATOM   634  C  CZ  . TYR A 1 105 ? -28.08899 1.08567  -26.25265 1.000 86.91000  ? 85  TYR A CZ  1 
ATOM   635  O  OH  . TYR A 1 105 ? -26.76839 1.38831  -25.98986 1.000 97.08000  ? 85  TYR A OH  1 
ATOM   636  N  N   . PRO A 1 106 ? -32.30144 3.48894  -27.30812 1.000 66.96000  ? 86  PRO A N   1 
ATOM   637  C  CA  . PRO A 1 106 ? -31.95286 3.67890  -25.90156 1.000 73.93000  ? 86  PRO A CA  1 
ATOM   638  C  C   . PRO A 1 106 ? -33.19156 4.15410  -25.10843 1.000 68.79000  ? 86  PRO A C   1 
ATOM   639  O  O   . PRO A 1 106 ? -33.88576 5.06881  -25.55931 1.000 65.55000  ? 86  PRO A O   1 
ATOM   640  C  CB  . PRO A 1 106 ? -30.80997 4.70201  -25.98430 1.000 65.36000  ? 86  PRO A CB  1 
ATOM   641  C  CG  . PRO A 1 106 ? -31.10834 5.51082  -27.20363 1.000 71.01000  ? 86  PRO A CG  1 
ATOM   642  C  CD  . PRO A 1 106 ? -31.88636 4.62214  -28.14756 1.000 67.71000  ? 86  PRO A CD  1 
ATOM   643  N  N   . ASN A 1 107 ? -33.53706 3.54851  -23.96622 1.000 66.41000  ? 87  ASN A N   1 
ATOM   644  C  CA  . ASN A 1 107 ? -34.63270 4.09743  -23.17105 1.000 61.34000  ? 87  ASN A CA  1 
ATOM   645  C  C   . ASN A 1 107 ? -34.11660 5.20803  -22.25633 1.000 63.99000  ? 87  ASN A C   1 
ATOM   646  O  O   . ASN A 1 107 ? -32.93542 5.56631  -22.27466 1.000 65.84000  ? 87  ASN A O   1 
ATOM   647  C  CB  . ASN A 1 107 ? -35.36746 2.99793  -22.40242 1.000 53.16000  ? 87  ASN A CB  1 
ATOM   648  C  CG  . ASN A 1 107 ? -34.52011 2.31728  -21.35196 1.000 60.98000  ? 87  ASN A CG  1 
ATOM   649  O  OD1 . ASN A 1 107 ? -33.54321 2.86754  -20.86276 1.000 60.04000  ? 87  ASN A OD1 1 
ATOM   650  N  ND2 . ASN A 1 107 ? -34.91599 1.10678  -20.98269 1.000 55.63000  ? 87  ASN A ND2 1 
ATOM   651  N  N   . HIS A 1 108 ? -35.01850 5.78313  -21.45933 1.000 68.77000  ? 88  HIS A N   1 
ATOM   652  C  CA  . HIS A 1 108 ? -34.64523 6.96819  -20.69715 1.000 62.83000  ? 88  HIS A CA  1 
ATOM   653  C  C   . HIS A 1 108 ? -33.55056 6.66703  -19.68367 1.000 58.33000  ? 88  HIS A C   1 
ATOM   654  O  O   . HIS A 1 108 ? -32.75887 7.55258  -19.35074 1.000 69.69000  ? 88  HIS A O   1 
ATOM   655  C  CB  . HIS A 1 108 ? -35.87051 7.57257  -20.01284 1.000 70.85000  ? 88  HIS A CB  1 
ATOM   656  C  CG  . HIS A 1 108 ? -36.79702 8.27914  -20.95894 1.000 73.23000  ? 88  HIS A CG  1 
ATOM   657  N  ND1 . HIS A 1 108 ? -37.62710 9.30859  -20.56969 1.000 80.55000  ? 88  HIS A ND1 1 
ATOM   658  C  CD2 . HIS A 1 108 ? -37.03182 8.09125  -22.28004 1.000 76.91000  ? 88  HIS A CD2 1 
ATOM   659  C  CE1 . HIS A 1 108 ? -38.32850 9.72640  -21.60930 1.000 77.38000  ? 88  HIS A CE1 1 
ATOM   660  N  NE2 . HIS A 1 108 ? -37.98457 9.00673  -22.66067 1.000 75.01000  ? 88  HIS A NE2 1 
ATOM   661  N  N   . ILE A 1 109 ? -33.46824 5.43175  -19.20207 1.000 59.57000  ? 89  ILE A N   1 
ATOM   662  C  CA  . ILE A 1 109 ? -32.34506 5.04381  -18.36112 1.000 54.57000  ? 89  ILE A CA  1 
ATOM   663  C  C   . ILE A 1 109 ? -31.05786 5.05467  -19.16793 1.000 64.95000  ? 89  ILE A C   1 
ATOM   664  O  O   . ILE A 1 109 ? -30.07562 5.70529  -18.78830 1.000 66.23000  ? 89  ILE A O   1 
ATOM   665  C  CB  . ILE A 1 109 ? -32.60486 3.67018  -17.71867 1.000 63.25000  ? 89  ILE A CB  1 
ATOM   666  C  CG1 . ILE A 1 109 ? -33.89646 3.70610  -16.88284 1.000 58.22000  ? 89  ILE A CG1 1 
ATOM   667  C  CG2 . ILE A 1 109 ? -31.39815 3.24506  -16.88936 1.000 61.78000  ? 89  ILE A CG2 1 
ATOM   668  N  N   . ASP A 1 110 ? -31.05239 4.33396  -20.29737 1.000 61.75000  ? 90  ASP A N   1 
ATOM   669  C  CA  . ASP A 1 110 ? -29.92206 4.36009  -21.22617 1.000 63.01000  ? 90  ASP A CA  1 
ATOM   670  C  C   . ASP A 1 110 ? -29.45996 5.78278  -21.52879 1.000 65.42000  ? 90  ASP A C   1 
ATOM   671  O  O   . ASP A 1 110 ? -28.25533 6.07032  -21.52836 1.000 69.04000  ? 90  ASP A O   1 
ATOM   672  C  CB  . ASP A 1 110 ? -30.30350 3.67141  -22.53517 1.000 57.46000  ? 90  ASP A CB  1 
ATOM   673  C  CG  . ASP A 1 110 ? -30.52678 2.19361  -22.38070 1.000 54.23000  ? 90  ASP A CG  1 
ATOM   674  O  OD1 . ASP A 1 110 ? -29.71687 1.52881  -21.69672 1.000 62.74000  ? 90  ASP A OD1 1 
ATOM   675  O  OD2 . ASP A 1 110 ? -31.51782 1.70112  -22.96518 1.000 59.44000  ? 90  ASP A OD2 1 
ATOM   676  N  N   . LEU A 1 111 ? -30.40095 6.68619  -21.81260 1.000 64.49000  ? 91  LEU A N   1 
ATOM   677  C  CA  . LEU A 1 111 ? -30.00061 8.04494  -22.15488 1.000 65.06000  ? 91  LEU A CA  1 
ATOM   678  C  C   . LEU A 1 111 ? -29.42438 8.77352  -20.94582 1.000 72.36000  ? 91  LEU A C   1 
ATOM   679  O  O   . LEU A 1 111 ? -28.57467 9.65801  -21.10481 1.000 72.94000  ? 91  LEU A O   1 
ATOM   680  C  CB  . LEU A 1 111 ? -31.18061 8.81870  -22.74186 1.000 67.48000  ? 91  LEU A CB  1 
ATOM   681  C  CG  . LEU A 1 111 ? -31.66240 8.46861  -24.16169 1.000 67.96000  ? 91  LEU A CG  1 
ATOM   682  C  CD1 . LEU A 1 111 ? -32.73067 9.44357  -24.61627 1.000 60.11000  ? 91  LEU A CD1 1 
ATOM   683  C  CD2 . LEU A 1 111 ? -30.52618 8.43405  -25.17274 1.000 69.30000  ? 91  LEU A CD2 1 
ATOM   684  N  N   . TRP A 1 112 ? -29.85209 8.41260  -19.72899 1.000 70.17000  ? 92  TRP A N   1 
ATOM   685  C  CA  . TRP A 1 112 ? -29.22361 9.01619  -18.56414 1.000 69.82000  ? 92  TRP A CA  1 
ATOM   686  C  C   . TRP A 1 112 ? -27.80207 8.49965  -18.38445 1.000 74.57000  ? 92  TRP A C   1 
ATOM   687  O  O   . TRP A 1 112 ? -26.88677 9.27761  -18.07633 1.000 71.50000  ? 92  TRP A O   1 
ATOM   688  C  CB  . TRP A 1 112 ? -30.02956 8.76702  -17.29734 1.000 68.51000  ? 92  TRP A CB  1 
ATOM   689  C  CG  . TRP A 1 112 ? -29.39600 9.52227  -16.18922 1.000 64.43000  ? 92  TRP A CG  1 
ATOM   690  C  CD1 . TRP A 1 112 ? -28.53206 9.03946  -15.24831 1.000 66.22000  ? 92  TRP A CD1 1 
ATOM   691  C  CD2 . TRP A 1 112 ? -29.51805 10.92486 -15.93611 1.000 70.46000  ? 92  TRP A CD2 1 
ATOM   692  N  NE1 . TRP A 1 112 ? -28.12226 10.05306 -14.41405 1.000 68.04000  ? 92  TRP A NE1 1 
ATOM   693  C  CE2 . TRP A 1 112 ? -28.71481 11.22017 -14.81639 1.000 66.15000  ? 92  TRP A CE2 1 
ATOM   694  C  CE3 . TRP A 1 112 ? -30.24276 11.95588 -16.53671 1.000 72.73000  ? 92  TRP A CE3 1 
ATOM   695  C  CZ2 . TRP A 1 112 ? -28.61698 12.50100 -14.28857 1.000 71.58000  ? 92  TRP A CZ2 1 
ATOM   696  C  CZ3 . TRP A 1 112 ? -30.14299 13.22126 -16.01694 1.000 67.38000  ? 92  TRP A CZ3 1 
ATOM   697  C  CH2 . TRP A 1 112 ? -29.33550 13.48745 -14.90010 1.000 73.59000  ? 92  TRP A CH2 1 
ATOM   698  N  N   . LYS A 1 113 ? -27.59945 7.18742  -18.56528 1.000 74.51000  ? 93  LYS A N   1 
ATOM   699  C  CA  . LYS A 1 113 ? -26.25341 6.62871  -18.48862 1.000 75.76000  ? 93  LYS A CA  1 
ATOM   700  C  C   . LYS A 1 113 ? -25.32087 7.30008  -19.49234 1.000 79.53000  ? 93  LYS A C   1 
ATOM   701  O  O   . LYS A 1 113 ? -24.16593 7.60629  -19.17059 1.000 81.95000  ? 93  LYS A O   1 
ATOM   702  C  CB  . LYS A 1 113 ? -26.29489 5.12160  -18.71613 1.000 74.55000  ? 93  LYS A CB  1 
ATOM   703  C  CG  . LYS A 1 113 ? -26.76470 4.33316  -17.52738 1.000 74.13000  ? 93  LYS A CG  1 
ATOM   704  C  CD  . LYS A 1 113 ? -27.19446 2.94221  -17.92729 1.000 76.24000  ? 93  LYS A CD  1 
ATOM   705  C  CE  . LYS A 1 113 ? -26.08881 2.24169  -18.70317 1.000 84.71000  ? 93  LYS A CE  1 
ATOM   706  N  NZ  . LYS A 1 113 ? -26.30785 0.77360  -18.80980 1.000 84.12000  ? 93  LYS A NZ  1 
ATOM   707  N  N   . GLN A 1 114 ? -25.80371 7.54846  -20.70987 1.000 70.92000  ? 94  GLN A N   1 
ATOM   708  C  CA  . GLN A 1 114 ? -24.96525 8.22311  -21.69801 1.000 77.89000  ? 94  GLN A CA  1 
ATOM   709  C  C   . GLN A 1 114 ? -24.49929 9.56931  -21.17094 1.000 80.06000  ? 94  GLN A C   1 
ATOM   710  O  O   . GLN A 1 114 ? -23.31231 9.90335  -21.24740 1.000 84.14000  ? 94  GLN A O   1 
ATOM   711  C  CB  . GLN A 1 114 ? -25.71629 8.41613  -23.02121 1.000 68.53000  ? 94  GLN A CB  1 
ATOM   712  C  CG  . GLN A 1 114 ? -25.79942 7.21651  -23.92735 1.000 67.89000  ? 94  GLN A CG  1 
ATOM   713  C  CD  . GLN A 1 114 ? -26.70071 7.47941  -25.14802 1.000 76.03000  ? 94  GLN A CD  1 
ATOM   714  O  OE1 . GLN A 1 114 ? -26.82982 8.62345  -25.61665 1.000 79.04000  ? 94  GLN A OE1 1 
ATOM   715  N  NE2 . GLN A 1 114 ? -27.32785 6.41832  -25.66106 1.000 71.33000  ? 94  GLN A NE2 1 
ATOM   716  N  N   . PHE A 1 115 ? -25.43206 10.35861 -20.63447 1.000 82.53000  ? 95  PHE A N   1 
ATOM   717  C  CA  . PHE A 1 115 ? -25.08244 11.66511 -20.09103 1.000 80.14000  ? 95  PHE A CA  1 
ATOM   718  C  C   . PHE A 1 115 ? -24.07841 11.53207 -18.95903 1.000 76.49000  ? 95  PHE A C   1 
ATOM   719  O  O   . PHE A 1 115 ? -23.10741 12.29374 -18.88938 1.000 78.24000  ? 95  PHE A O   1 
ATOM   720  C  CB  . PHE A 1 115 ? -26.34568 12.38417 -19.61272 1.000 83.35000  ? 95  PHE A CB  1 
ATOM   721  C  CG  . PHE A 1 115 ? -26.08056 13.54057 -18.68285 1.000 73.26000  ? 95  PHE A CG  1 
ATOM   722  C  CD1 . PHE A 1 115 ? -25.53600 14.72597 -19.16287 1.000 73.65000  ? 95  PHE A CD1 1 
ATOM   723  C  CD2 . PHE A 1 115 ? -26.37748 13.44212 -17.33002 1.000 75.42000  ? 95  PHE A CD2 1 
ATOM   724  C  CE1 . PHE A 1 115 ? -25.28328 15.78928 -18.30750 1.000 79.32000  ? 95  PHE A CE1 1 
ATOM   725  C  CE2 . PHE A 1 115 ? -26.13540 14.50691 -16.46787 1.000 74.96000  ? 95  PHE A CE2 1 
ATOM   726  C  CZ  . PHE A 1 115 ? -25.58889 15.68074 -16.95485 1.000 73.70000  ? 95  PHE A CZ  1 
ATOM   727  N  N   . VAL A 1 116 ? -24.28710 10.55462 -18.07492 1.000 77.72000  ? 96  VAL A N   1 
ATOM   728  C  CA  . VAL A 1 116 ? -23.36504 10.33779 -16.96412 1.000 75.64000  ? 96  VAL A CA  1 
ATOM   729  C  C   . VAL A 1 116 ? -21.94393 10.15040 -17.48357 1.000 82.00000  ? 96  VAL A C   1 
ATOM   730  O  O   . VAL A 1 116 ? -21.02033 10.88106 -17.11020 1.000 80.96000  ? 96  VAL A O   1 
ATOM   731  C  CB  . VAL A 1 116 ? -23.82763 9.13584  -16.12315 1.000 71.37000  ? 96  VAL A CB  1 
ATOM   732  C  CG2 . VAL A 1 116 ? -22.69039 8.60317  -15.30444 1.000 75.28000  ? 96  VAL A CG2 1 
ATOM   733  N  N   . PHE A 1 117 ? -21.75807 9.19197  -18.39003 1.000 82.75000  ? 97  PHE A N   1 
ATOM   734  C  CA  . PHE A 1 117 ? -20.41078 8.85643  -18.83868 1.000 80.43000  ? 97  PHE A CA  1 
ATOM   735  C  C   . PHE A 1 117 ? -19.74533 10.02667 -19.54419 1.000 82.68000  ? 97  PHE A C   1 
ATOM   736  O  O   . PHE A 1 117 ? -18.54702 10.27131 -19.35686 1.000 85.07000  ? 97  PHE A O   1 
ATOM   737  C  CB  . PHE A 1 117 ? -20.45465 7.64014  -19.74970 1.000 73.40000  ? 97  PHE A CB  1 
ATOM   738  C  CG  . PHE A 1 117 ? -21.05002 6.45268  -19.10350 1.000 71.20000  ? 97  PHE A CG  1 
ATOM   739  C  CD1 . PHE A 1 117 ? -21.81114 5.57633  -19.81854 1.000 70.79000  ? 97  PHE A CD1 1 
ATOM   740  C  CD2 . PHE A 1 117 ? -20.85295 6.23109  -17.75236 1.000 75.36000  ? 97  PHE A CD2 1 
ATOM   741  C  CE1 . PHE A 1 117 ? -22.35728 4.48157  -19.21849 1.000 76.37000  ? 97  PHE A CE1 1 
ATOM   742  C  CE2 . PHE A 1 117 ? -21.39981 5.14146  -17.13486 1.000 80.42000  ? 97  PHE A CE2 1 
ATOM   743  C  CZ  . PHE A 1 117 ? -22.15863 4.25684  -17.87259 1.000 80.29000  ? 97  PHE A CZ  1 
ATOM   744  N  N   . ALA A 1 118 ? -20.50864 10.78084 -20.33586 1.000 86.28000  ? 98  ALA A N   1 
ATOM   745  C  CA  . ALA A 1 118 ? -19.94498 11.92729 -21.03779 1.000 79.69000  ? 98  ALA A CA  1 
ATOM   746  C  C   . ALA A 1 118 ? -19.48163 13.03469 -20.10008 1.000 80.82000  ? 98  ALA A C   1 
ATOM   747  O  O   . ALA A 1 118 ? -18.76906 13.93553 -20.55622 1.000 89.07000  ? 98  ALA A O   1 
ATOM   748  C  CB  . ALA A 1 118 ? -20.95818 12.49673 -22.02299 1.000 75.36000  ? 98  ALA A CB  1 
ATOM   749  N  N   . LEU A 1 119 ? -19.87911 13.01537 -18.82353 1.000 85.14000  ? 99  LEU A N   1 
ATOM   750  C  CA  . LEU A 1 119 ? -19.28964 13.89910 -17.82269 1.000 85.37000  ? 99  LEU A CA  1 
ATOM   751  C  C   . LEU A 1 119 ? -18.04483 13.28609 -17.18140 1.000 85.87000  ? 99  LEU A C   1 
ATOM   752  O  O   . LEU A 1 119 ? -17.54360 13.81637 -16.18300 1.000 83.82000  ? 99  LEU A O   1 
ATOM   753  C  CB  . LEU A 1 119 ? -20.32704 14.28176 -16.73662 1.000 34.08000  ? 99  LEU A CB  1 
ATOM   754  N  N   . GLY A 1 120 ? -17.54960 12.17576 -17.71952 1.000 82.13000  ? 100 GLY A N   1 
ATOM   755  C  CA  . GLY A 1 120 ? -16.27923 11.63427 -17.29011 1.000 86.18000  ? 100 GLY A CA  1 
ATOM   756  C  C   . GLY A 1 120 ? -16.34921 10.56235 -16.23247 1.000 83.84000  ? 100 GLY A C   1 
ATOM   757  O  O   . GLY A 1 120 ? -15.33765 10.30500 -15.56753 1.000 85.16000  ? 100 GLY A O   1 
ATOM   758  N  N   . VAL A 1 121 ? -17.49829 9.91917  -16.06235 1.000 84.21000  ? 101 VAL A N   1 
ATOM   759  C  CA  . VAL A 1 121 ? -17.66659 8.86741  -15.07222 1.000 80.84000  ? 101 VAL A CA  1 
ATOM   760  C  C   . VAL A 1 121 ? -17.46319 7.51629  -15.73995 1.000 85.34000  ? 101 VAL A C   1 
ATOM   761  O  O   . VAL A 1 121 ? -17.88001 7.29831  -16.88820 1.000 86.32000  ? 101 VAL A O   1 
ATOM   762  C  CB  . VAL A 1 121 ? -19.05037 8.96261  -14.40004 1.000 83.17000  ? 101 VAL A CB  1 
ATOM   763  C  CG1 . VAL A 1 121 ? -19.31547 7.76182  -13.49396 1.000 81.05000  ? 101 VAL A CG1 1 
ATOM   764  C  CG2 . VAL A 1 121 ? -19.15926 10.25399 -13.62082 1.000 84.09000  ? 101 VAL A CG2 1 
ATOM   765  N  N   . THR A 1 122 ? -16.80723 6.60636  -15.02162 1.000 82.63000  ? 102 THR A N   1 
ATOM   766  C  CA  . THR A 1 122 ? -16.63272 5.26558  -15.55822 1.000 84.14000  ? 102 THR A CA  1 
ATOM   767  C  C   . THR A 1 122 ? -17.80033 4.37164  -15.13640 1.000 87.77000  ? 102 THR A C   1 
ATOM   768  O  O   . THR A 1 122 ? -18.34661 4.54137  -14.04322 1.000 84.01000  ? 102 THR A O   1 
ATOM   769  C  CB  . THR A 1 122 ? -15.31298 4.66484  -15.08083 1.000 87.07000  ? 102 THR A CB  1 
ATOM   770  O  OG1 . THR A 1 122 ? -15.48288 4.10619  -13.77805 1.000 86.25000  ? 102 THR A OG1 1 
ATOM   771  N  N   . PRO A 1 123 ? -18.21691 3.44965  -16.01063 1.000 85.08000  ? 103 PRO A N   1 
ATOM   772  C  CA  . PRO A 1 123 ? -19.33864 2.55666  -15.67289 1.000 85.71000  ? 103 PRO A CA  1 
ATOM   773  C  C   . PRO A 1 123 ? -19.21972 1.88053  -14.31738 1.000 85.32000  ? 103 PRO A C   1 
ATOM   774  O  O   . PRO A 1 123 ? -20.24189 1.66780  -13.64924 1.000 83.12000  ? 103 PRO A O   1 
ATOM   775  C  CB  . PRO A 1 123 ? -19.30697 1.53239  -16.81449 1.000 82.37000  ? 103 PRO A CB  1 
ATOM   776  C  CG  . PRO A 1 123 ? -18.75684 2.27785  -17.97285 1.000 80.75000  ? 103 PRO A CG  1 
ATOM   777  C  CD  . PRO A 1 123 ? -17.89296 3.40393  -17.44841 1.000 85.08000  ? 103 PRO A CD  1 
ATOM   778  N  N   . GLU A 1 124 ? -18.00577 1.52449  -13.88939 1.000 85.33000  ? 104 GLU A N   1 
ATOM   779  C  CA  . GLU A 1 124 ? -17.85226 0.90749  -12.57567 1.000 84.36000  ? 104 GLU A CA  1 
ATOM   780  C  C   . GLU A 1 124 ? -18.06519 1.92170  -11.46157 1.000 87.09000  ? 104 GLU A C   1 
ATOM   781  O  O   . GLU A 1 124 ? -18.52045 1.55257  -10.37107 1.000 86.21000  ? 104 GLU A O   1 
ATOM   782  C  CB  . GLU A 1 124 ? -16.47318 0.25618  -12.44494 1.000 83.33000  ? 104 GLU A CB  1 
ATOM   783  N  N   . GLU A 1 125 ? -17.74165 3.19643  -11.71734 1.000 87.73000  ? 105 GLU A N   1 
ATOM   784  C  CA  . GLU A 1 125 ? -18.01377 4.25558  -10.74823 1.000 84.69000  ? 105 GLU A CA  1 
ATOM   785  C  C   . GLU A 1 125 ? -19.51412 4.41959  -10.54692 1.000 86.61000  ? 105 GLU A C   1 
ATOM   786  O  O   . GLU A 1 125 ? -20.02298 4.26913  -9.42914  1.000 87.33000  ? 105 GLU A O   1 
ATOM   787  C  CB  . GLU A 1 125 ? -17.38166 5.57231  -11.21042 1.000 82.88000  ? 105 GLU A CB  1 
ATOM   788  C  CG  . GLU A 1 125 ? -15.91568 5.75374  -10.82081 1.000 83.01000  ? 105 GLU A CG  1 
ATOM   789  C  CD  . GLU A 1 125 ? -15.21284 6.85774  -11.61364 1.000 89.63000  ? 105 GLU A CD  1 
ATOM   790  O  OE1 . GLU A 1 125 ? -15.79874 7.35935  -12.59946 1.000 84.31000  ? 105 GLU A OE1 1 
ATOM   791  O  OE2 . GLU A 1 125 ? -14.08253 7.23948  -11.23861 1.000 89.28000  ? 105 GLU A OE2 1 
ATOM   792  N  N   . LEU A 1 126 ? -20.23897 4.70735  -11.63463 1.000 82.19000  ? 106 LEU A N   1 
ATOM   793  C  CA  . LEU A 1 126 ? -21.69678 4.82051  -11.59163 1.000 81.69000  ? 106 LEU A CA  1 
ATOM   794  C  C   . LEU A 1 126 ? -22.34555 3.61452  -10.92727 1.000 79.25000  ? 106 LEU A C   1 
ATOM   795  O  O   . LEU A 1 126 ? -23.13477 3.75081  -9.98589  1.000 88.96000  ? 106 LEU A O   1 
ATOM   796  C  CB  . LEU A 1 126 ? -22.25156 4.99652  -13.00625 1.000 80.84000  ? 106 LEU A CB  1 
ATOM   797  C  CG  . LEU A 1 126 ? -23.77719 4.98386  -13.09809 1.000 76.58000  ? 106 LEU A CG  1 
ATOM   798  C  CD1 . LEU A 1 126 ? -24.34897 6.04887  -12.18677 1.000 76.48000  ? 106 LEU A CD1 1 
ATOM   799  C  CD2 . LEU A 1 126 ? -24.24466 5.18088  -14.51154 1.000 71.78000  ? 106 LEU A CD2 1 
ATOM   800  N  N   A GLU A 1 127 ? -22.02931 2.41286  -11.40918 0.567 84.13000  ? 107 GLU A N   1 
ATOM   801  N  N   B GLU A 1 127 ? -22.03093 2.41353  -11.41528 0.433 84.13000  ? 107 GLU A N   1 
ATOM   802  C  CA  A GLU A 1 127 ? -22.61406 1.21811  -10.81949 0.567 84.47000  ? 107 GLU A CA  1 
ATOM   803  C  CA  B GLU A 1 127 ? -22.60331 1.20879  -10.83333 0.433 84.47000  ? 107 GLU A CA  1 
ATOM   804  C  C   A GLU A 1 127 ? -22.08757 0.96593  -9.41847  0.567 88.33000  ? 107 GLU A C   1 
ATOM   805  C  C   B GLU A 1 127 ? -22.07997 0.95523  -9.42896  0.433 88.33000  ? 107 GLU A C   1 
ATOM   806  O  O   A GLU A 1 127 ? -22.72355 0.23574  -8.65205  0.567 90.85000  ? 107 GLU A O   1 
ATOM   807  O  O   B GLU A 1 127 ? -22.71534 0.21950  -8.66708  0.433 90.85000  ? 107 GLU A O   1 
ATOM   808  C  CB  A GLU A 1 127 ? -22.34902 -0.00108 -11.70757 0.567 88.67000  ? 107 GLU A CB  1 
ATOM   809  C  CB  B GLU A 1 127 ? -22.32020 0.00386  -11.73624 0.433 88.67000  ? 107 GLU A CB  1 
ATOM   810  C  CG  A GLU A 1 127 ? -23.58344 -0.54968 -12.40170 0.567 85.18000  ? 107 GLU A CG  1 
ATOM   811  C  CG  B GLU A 1 127 ? -23.52354 -0.89143 -12.00327 0.433 85.18000  ? 107 GLU A CG  1 
ATOM   812  C  CD  A GLU A 1 127 ? -24.13223 0.40008  -13.44196 0.567 88.61000  ? 107 GLU A CD  1 
ATOM   813  C  CD  B GLU A 1 127 ? -23.96384 -1.66212 -10.77356 0.433 88.61000  ? 107 GLU A CD  1 
ATOM   814  O  OE1 A GLU A 1 127 ? -23.37501 1.27498  -13.90957 0.567 90.04000  ? 107 GLU A OE1 1 
ATOM   815  O  OE1 B GLU A 1 127 ? -23.12763 -2.38166 -10.19684 0.433 86.21000  ? 107 GLU A OE1 1 
ATOM   816  O  OE2 A GLU A 1 127 ? -25.31811 0.26666  -13.80005 0.567 86.21000  ? 107 GLU A OE2 1 
ATOM   817  O  OE2 B GLU A 1 127 ? -25.14506 -1.55322 -10.38696 0.433 90.04000  ? 107 GLU A OE2 1 
ATOM   818  N  N   . ALA A 1 128 ? -20.94508 1.55231  -9.07277  1.000 90.15000  ? 108 ALA A N   1 
ATOM   819  C  CA  . ALA A 1 128 ? -20.37238 1.42401  -7.74437  1.000 85.08000  ? 108 ALA A CA  1 
ATOM   820  C  C   . ALA A 1 128 ? -20.77617 2.55926  -6.81403  1.000 88.93000  ? 108 ALA A C   1 
ATOM   821  O  O   . ALA A 1 128 ? -20.32552 2.58687  -5.66030  1.000 90.85000  ? 108 ALA A O   1 
ATOM   822  N  N   . HIS A 1 129 ? -21.61936 3.48302  -7.27134  1.000 79.30000  ? 109 HIS A N   1 
ATOM   823  C  CA  . HIS A 1 129 ? -21.96150 4.63619  -6.45502  1.000 82.29000  ? 109 HIS A CA  1 
ATOM   824  C  C   . HIS A 1 129 ? -22.98899 4.28976  -5.37883  1.000 84.41000  ? 109 HIS A C   1 
ATOM   825  O  O   . HIS A 1 129 ? -23.97266 3.58482  -5.62979  1.000 80.96000  ? 109 HIS A O   1 
ATOM   826  C  CB  . HIS A 1 129 ? -22.48774 5.77411  -7.32130  1.000 82.88000  ? 109 HIS A CB  1 
ATOM   827  C  CG  . HIS A 1 129 ? -22.90255 6.97127  -6.52729  1.000 86.18000  ? 109 HIS A CG  1 
ATOM   828  N  ND1 . HIS A 1 129 ? -22.04309 8.01115  -6.24660  1.000 86.87000  ? 109 HIS A ND1 1 
ATOM   829  C  CD2 . HIS A 1 129 ? -24.07628 7.27772  -5.92381  1.000 82.26000  ? 109 HIS A CD2 1 
ATOM   830  C  CE1 . HIS A 1 129 ? -22.67387 8.91318  -5.51693  1.000 82.40000  ? 109 HIS A CE1 1 
ATOM   831  N  NE2 . HIS A 1 129 ? -23.90751 8.49153  -5.30547  1.000 84.37000  ? 109 HIS A NE2 1 
ATOM   832  N  N   . GLU A 1 130 ? -22.73860 4.79430  -4.16896  1.000 83.33000  ? 110 GLU A N   1 
ATOM   833  C  CA  . GLU A 1 130 ? -23.66961 4.67879  -3.05076  1.000 82.28000  ? 110 GLU A CA  1 
ATOM   834  C  C   . GLU A 1 130 ? -24.58542 5.89089  -3.03629  1.000 86.54000  ? 110 GLU A C   1 
ATOM   835  O  O   . GLU A 1 130 ? -24.09313 7.02413  -2.94927  1.000 83.97000  ? 110 GLU A O   1 
ATOM   836  C  CB  . GLU A 1 130 ? -22.92074 4.58058  -1.72308  1.000 88.37000  ? 110 GLU A CB  1 
ATOM   837  C  CG  . GLU A 1 130 ? -23.43678 3.52397  -0.71191  1.000 94.26000  ? 110 GLU A CG  1 
ATOM   838  C  CD  . GLU A 1 130 ? -23.85977 2.19701  -1.33882  1.000 103.07000 ? 110 GLU A CD  1 
ATOM   839  O  OE1 . GLU A 1 130 ? -24.95421 1.69347  -0.98036  1.000 101.54000 ? 110 GLU A OE1 1 
ATOM   840  O  OE2 . GLU A 1 130 ? -23.09541 1.64174  -2.16189  1.000 99.19000  ? 110 GLU A OE2 1 
ATOM   841  N  N   . PRO A 1 131 ? -25.90186 5.71029  -3.11032  1.000 85.10000  ? 111 PRO A N   1 
ATOM   842  C  CA  . PRO A 1 131 ? -26.79281 6.86784  -3.24552  1.000 82.94000  ? 111 PRO A CA  1 
ATOM   843  C  C   . PRO A 1 131 ? -27.06905 7.53734  -1.90644  1.000 78.80000  ? 111 PRO A C   1 
ATOM   844  O  O   . PRO A 1 131 ? -27.27395 6.88263  -0.87801  1.000 73.52000  ? 111 PRO A O   1 
ATOM   845  C  CB  . PRO A 1 131 ? -28.06789 6.26732  -3.85051  1.000 77.35000  ? 111 PRO A CB  1 
ATOM   846  C  CG  . PRO A 1 131 ? -27.89035 4.75288  -3.78511  1.000 84.45000  ? 111 PRO A CG  1 
ATOM   847  C  CD  . PRO A 1 131 ? -26.64053 4.44383  -3.03118  1.000 81.25000  ? 111 PRO A CD  1 
ATOM   848  N  N   . SER A 1 132 ? -27.08972 8.86692  -1.95442  1.000 75.65000  ? 112 SER A N   1 
ATOM   849  C  CA  . SER A 1 132 ? -27.21940 9.72352  -0.78943  1.000 71.05000  ? 112 SER A CA  1 
ATOM   850  C  C   . SER A 1 132 ? -28.57098 9.55245  -0.10912  1.000 71.97000  ? 112 SER A C   1 
ATOM   851  O  O   . SER A 1 132 ? -29.55608 9.13532  -0.71522  1.000 69.66000  ? 112 SER A O   1 
ATOM   852  C  CB  . SER A 1 132 ? -27.05971 11.17390 -1.21285  1.000 67.56000  ? 112 SER A CB  1 
ATOM   853  O  OG  . SER A 1 132 ? -28.21831 11.59648 -1.91246  1.000 71.11000  ? 112 SER A OG  1 
ATOM   854  N  N   . GLU A 1 133 ? -28.61772 9.91213  1.17524   1.000 69.49000  ? 113 GLU A N   1 
ATOM   855  C  CA  . GLU A 1 133 ? -29.89305 9.86080  1.88419   1.000 72.88000  ? 113 GLU A CA  1 
ATOM   856  C  C   . GLU A 1 133 ? -30.86864 10.88614 1.32353   1.000 70.20000  ? 113 GLU A C   1 
ATOM   857  O  O   . GLU A 1 133 ? -32.08326 10.67410 1.38131   1.000 65.16000  ? 113 GLU A O   1 
ATOM   858  C  CB  . GLU A 1 133 ? -29.68785 10.07608 3.39235   1.000 76.25000  ? 113 GLU A CB  1 
ATOM   859  C  CG  . GLU A 1 133 ? -28.98922 8.91830  4.13086   1.000 80.17000  ? 113 GLU A CG  1 
ATOM   860  C  CD  . GLU A 1 133 ? -29.86740 7.67651  4.29388   1.000 87.85000  ? 113 GLU A CD  1 
ATOM   861  O  OE1 . GLU A 1 133 ? -31.10913 7.78345  4.15049   1.000 94.27000  ? 113 GLU A OE1 1 
ATOM   862  O  OE2 . GLU A 1 133 ? -29.30938 6.58849  4.56194   1.000 90.32000  ? 113 GLU A OE2 1 
ATOM   863  N  N   . ALA A 1 134 ? -30.34766 11.99091 0.77330   1.000 72.48000  ? 114 ALA A N   1 
ATOM   864  C  CA  . ALA A 1 134 ? -31.18434 12.96960 0.08595   1.000 64.24000  ? 114 ALA A CA  1 
ATOM   865  C  C   . ALA A 1 134 ? -31.91832 12.33754 -1.09171  1.000 72.92000  ? 114 ALA A C   1 
ATOM   866  O  O   . ALA A 1 134 ? -33.11416 12.58514 -1.28878  1.000 68.77000  ? 114 ALA A O   1 
ATOM   867  N  N   . ALA A 1 135 ? -31.22084 11.50496 -1.87775  1.000 73.39000  ? 115 ALA A N   1 
ATOM   868  C  CA  . ALA A 1 135 ? -31.84677 10.84977 -3.02704  1.000 71.12000  ? 115 ALA A CA  1 
ATOM   869  C  C   . ALA A 1 135 ? -32.81031 9.75324  -2.59035  1.000 67.36000  ? 115 ALA A C   1 
ATOM   870  O  O   . ALA A 1 135 ? -33.90406 9.61966  -3.14994  1.000 64.07000  ? 115 ALA A O   1 
ATOM   871  C  CB  . ALA A 1 135 ? -30.77552 10.27502 -3.95637  1.000 71.47000  ? 115 ALA A CB  1 
ATOM   872  N  N   . LYS A 1 136 ? -32.41643 8.95211  -1.60204  1.000 62.99000  ? 116 LYS A N   1 
ATOM   873  C  CA  . LYS A 1 136 ? -33.29779 7.90160  -1.11469  1.000 67.50000  ? 116 LYS A CA  1 
ATOM   874  C  C   . LYS A 1 136 ? -34.60493 8.48352  -0.58826  1.000 70.47000  ? 116 LYS A C   1 
ATOM   875  O  O   . LYS A 1 136 ? -35.67961 7.91072  -0.81079  1.000 69.66000  ? 116 LYS A O   1 
ATOM   876  C  CB  . LYS A 1 136 ? -32.57508 7.08728  -0.04018  1.000 70.26000  ? 116 LYS A CB  1 
ATOM   877  C  CG  . LYS A 1 136 ? -31.28382 6.42310  -0.54199  1.000 76.38000  ? 116 LYS A CG  1 
ATOM   878  C  CD  . LYS A 1 136 ? -30.29679 6.13149  0.59254   1.000 76.36000  ? 116 LYS A CD  1 
ATOM   879  C  CE  . LYS A 1 136 ? -30.74781 5.00093  1.51033   1.000 84.76000  ? 116 LYS A CE  1 
ATOM   880  N  NZ  . LYS A 1 136 ? -30.01353 3.73180  1.26772   1.000 88.83000  ? 116 LYS A NZ  1 
ATOM   881  N  N   . ALA A 1 137 ? -34.53983 9.64113  0.08115   1.000 62.58000  ? 117 ALA A N   1 
ATOM   882  C  CA  . ALA A 1 137 ? -35.75597 10.25453 0.61050   1.000 65.10000  ? 117 ALA A CA  1 
ATOM   883  C  C   . ALA A 1 137 ? -36.63520 10.80977 -0.50444  1.000 60.90000  ? 117 ALA A C   1 
ATOM   884  O  O   . ALA A 1 137 ? -37.86527 10.71044 -0.43679  1.000 63.98000  ? 117 ALA A O   1 
ATOM   885  C  CB  . ALA A 1 137 ? -35.40986 11.36434 1.60120   1.000 69.85000  ? 117 ALA A CB  1 
ATOM   886  N  N   . LYS A 1 138 ? -36.02781 11.42597 -1.52133  1.000 71.46000  ? 118 LYS A N   1 
ATOM   887  C  CA  . LYS A 1 138 ? -36.79811 11.90299 -2.66981  1.000 62.43000  ? 118 LYS A CA  1 
ATOM   888  C  C   . LYS A 1 138 ? -37.55516 10.75646 -3.32717  1.000 64.73000  ? 118 LYS A C   1 
ATOM   889  O  O   . LYS A 1 138 ? -38.76706 10.83371 -3.52853  1.000 66.37000  ? 118 LYS A O   1 
ATOM   890  C  CB  . LYS A 1 138 ? -35.87008 12.58544 -3.67450  0.965 37.17000  ? 118 LYS A CB  1 
ATOM   891  C  CG  . LYS A 1 138 ? -36.45330 12.75575 -5.04653  0.661 37.17000  ? 118 LYS A CG  1 
ATOM   892  C  CD  . LYS A 1 138 ? -35.39165 13.21926 -6.03451  0.541 37.17000  ? 118 LYS A CD  1 
ATOM   893  C  CE  . LYS A 1 138 ? -34.52458 12.06719 -6.47481  0.761 37.17000  ? 118 LYS A CE  1 
ATOM   894  N  NZ  . LYS A 1 138 ? -33.47476 12.53519 -7.41076  0.795 37.17000  ? 118 LYS A NZ  1 
ATOM   895  N  N   . VAL A 1 139 ? -36.86006 9.66229  -3.62429  1.000 63.74000  ? 119 VAL A N   1 
ATOM   896  C  CA  . VAL A 1 139 ? -37.52281 8.50639  -4.21441  1.000 62.20000  ? 119 VAL A CA  1 
ATOM   897  C  C   . VAL A 1 139 ? -38.58555 7.95718  -3.27273  1.000 61.18000  ? 119 VAL A C   1 
ATOM   898  O  O   . VAL A 1 139 ? -39.68206 7.57125  -3.70619  1.000 66.98000  ? 119 VAL A O   1 
ATOM   899  C  CB  . VAL A 1 139 ? -36.48223 7.43632  -4.59903  1.000 68.62000  ? 119 VAL A CB  1 
ATOM   900  C  CG1 . VAL A 1 139 ? -37.13250 6.04722  -4.75394  1.000 57.21000  ? 119 VAL A CG1 1 
ATOM   901  C  CG2 . VAL A 1 139 ? -35.76441 7.86264  -5.86911  1.000 60.74000  ? 119 VAL A CG2 1 
ATOM   902  N  N   . ALA A 1 140 ? -38.29521 7.93728  -1.97101  1.000 65.05000  ? 120 ALA A N   1 
ATOM   903  C  CA  . ALA A 1 140 ? -39.26728 7.42188  -1.00787  1.000 58.22000  ? 120 ALA A CA  1 
ATOM   904  C  C   . ALA A 1 140 ? -40.54754 8.25451  -0.99310  1.000 52.63000  ? 120 ALA A C   1 
ATOM   905  O  O   . ALA A 1 140 ? -41.64655 7.70177  -0.88554  1.000 55.25000  ? 120 ALA A O   1 
ATOM   906  C  CB  . ALA A 1 140 ? -38.63622 7.34761  0.37760   1.000 56.64000  ? 120 ALA A CB  1 
ATOM   907  N  N   . THR A 1 141 ? -40.43533 9.57533  -1.14548  1.000 56.81000  ? 121 THR A N   1 
ATOM   908  C  CA  . THR A 1 141 ? -41.63155 10.41409 -1.24136  1.000 62.15000  ? 121 THR A CA  1 
ATOM   909  C  C   . THR A 1 141 ? -42.46332 10.06213 -2.47872  1.000 65.54000  ? 121 THR A C   1 
ATOM   910  O  O   . THR A 1 141 ? -43.69540 9.94991  -2.39863  1.000 62.42000  ? 121 THR A O   1 
ATOM   911  C  CB  . THR A 1 141 ? -41.25947 11.89562 -1.29486  1.000 64.76000  ? 121 THR A CB  1 
ATOM   912  O  OG1 . THR A 1 141 ? -40.30668 12.20322 -0.28185  1.000 62.31000  ? 121 THR A OG1 1 
ATOM   913  C  CG2 . THR A 1 141 ? -42.50067 12.71985 -1.02646  1.000 66.03000  ? 121 THR A CG2 1 
ATOM   914  N  N   . PHE A 1 142 ? -41.80525 9.92860  -3.64524  1.000 62.66000  ? 122 PHE A N   1 
ATOM   915  C  CA  . PHE A 1 142 ? -42.50785 9.56329  -4.87534  1.000 57.89000  ? 122 PHE A CA  1 
ATOM   916  C  C   . PHE A 1 142 ? -43.21759 8.23137  -4.71416  1.000 56.69000  ? 122 PHE A C   1 
ATOM   917  O  O   . PHE A 1 142 ? -44.39746 8.08760  -5.06789  1.000 57.07000  ? 122 PHE A O   1 
ATOM   918  C  CB  . PHE A 1 142 ? -41.52708 9.47998  -6.04827  1.000 60.68000  ? 122 PHE A CB  1 
ATOM   919  C  CG  . PHE A 1 142 ? -41.21049 10.78387 -6.65898  1.000 55.05000  ? 122 PHE A CG  1 
ATOM   920  C  CD1 . PHE A 1 142 ? -42.15422 11.44554 -7.40995  1.000 61.73000  ? 122 PHE A CD1 1 
ATOM   921  C  CD2 . PHE A 1 142 ? -39.96704 11.34963 -6.49578  1.000 58.04000  ? 122 PHE A CD2 1 
ATOM   922  C  CE1 . PHE A 1 142 ? -41.87786 12.66428 -7.96228  1.000 60.67000  ? 122 PHE A CE1 1 
ATOM   923  C  CE2 . PHE A 1 142 ? -39.68167 12.56397 -7.04558  1.000 53.99000  ? 122 PHE A CE2 1 
ATOM   924  C  CZ  . PHE A 1 142 ? -40.64518 13.22481 -7.77859  1.000 60.59000  ? 122 PHE A CZ  1 
ATOM   925  N  N   . MET A 1 143 ? -42.49844 7.23789  -4.16617  1.000 31.63000  ? 123 MET A N   1 
ATOM   926  C  CA  . MET A 1 143 ? -43.06108 5.89918  -4.04669  1.000 31.63000  ? 123 MET A CA  1 
ATOM   927  C  C   . MET A 1 143 ? -44.24324 5.93809  -3.10078  1.000 31.63000  ? 123 MET A C   1 
ATOM   928  O  O   . MET A 1 143 ? -45.29548 5.32426  -3.38209  1.000 31.63000  ? 123 MET A O   1 
ATOM   929  C  CB  . MET A 1 143 ? -41.98282 4.92177  -3.57328  1.000 31.63000  ? 123 MET A CB  1 
ATOM   930  C  CG  . MET A 1 143 ? -41.28818 4.12196  -4.75881  0.774 31.63000  ? 123 MET A CG  1 
ATOM   931  S  SD  . MET A 1 143 ? -42.47364 3.65594  -6.03696  0.396 31.63000  ? 123 MET A SD  1 
ATOM   932  C  CE  . MET A 1 143 ? -42.99707 2.01440  -5.53801  1.000 31.63000  ? 123 MET A CE  1 
ATOM   933  N  N   . ARG A 1 144 ? -44.10415 6.70106  -2.00083  1.000 56.24000  ? 124 ARG A N   1 
ATOM   934  C  CA  . ARG A 1 144 ? -45.16800 6.86626  -1.01312  1.000 57.91000  ? 124 ARG A CA  1 
ATOM   935  C  C   . ARG A 1 144 ? -46.47595 7.28937  -1.67102  1.000 57.66000  ? 124 ARG A C   1 
ATOM   936  O  O   . ARG A 1 144 ? -47.52964 6.68076  -1.46050  1.000 57.39000  ? 124 ARG A O   1 
ATOM   937  C  CB  . ARG A 1 144 ? -44.71673 7.90879  0.01882   1.000 66.02000  ? 124 ARG A CB  1 
ATOM   938  C  CG  . ARG A 1 144 ? -45.71195 8.25178  1.14138   1.000 69.33000  ? 124 ARG A CG  1 
ATOM   939  C  CD  . ARG A 1 144 ? -44.98164 8.45192  2.49837   1.000 71.98000  ? 124 ARG A CD  1 
ATOM   940  N  NE  . ARG A 1 144 ? -43.95647 9.48911  2.43693   1.000 70.56000  ? 124 ARG A NE  1 
ATOM   941  C  CZ  . ARG A 1 144 ? -44.21176 10.77889 2.26296   1.000 71.92000  ? 124 ARG A CZ  1 
ATOM   942  N  NH1 . ARG A 1 144 ? -45.45491 11.23440 2.20689   1.000 68.34000  ? 124 ARG A NH1 1 
ATOM   943  N  NH2 . ARG A 1 144 ? -43.19634 11.63580 2.16225   1.000 72.04000  ? 124 ARG A NH2 1 
ATOM   944  N  N   . TRP A 1 145 ? -46.41850 8.32559  -2.50058  1.000 55.90000  ? 125 TRP A N   1 
ATOM   945  C  CA  . TRP A 1 145 ? -47.63349 8.81652  -3.12893  1.000 53.16000  ? 125 TRP A CA  1 
ATOM   946  C  C   . TRP A 1 145 ? -48.14402 7.85570  -4.19152  1.000 56.96000  ? 125 TRP A C   1 
ATOM   947  O  O   . TRP A 1 145 ? -49.35593 7.63526  -4.29069  1.000 55.56000  ? 125 TRP A O   1 
ATOM   948  C  CB  . TRP A 1 145 ? -47.38073 10.20736 -3.68059  1.000 55.74000  ? 125 TRP A CB  1 
ATOM   949  C  CG  . TRP A 1 145 ? -47.48870 11.18083 -2.58443  1.000 66.65000  ? 125 TRP A CG  1 
ATOM   950  C  CD1 . TRP A 1 145 ? -46.48563 11.92371 -2.03122  1.000 66.17000  ? 125 TRP A CD1 1 
ATOM   951  C  CD2 . TRP A 1 145 ? -48.66892 11.47639 -1.83567  1.000 66.18000  ? 125 TRP A CD2 1 
ATOM   952  N  NE1 . TRP A 1 145 ? -46.97996 12.69512 -1.00724  1.000 65.25000  ? 125 TRP A NE1 1 
ATOM   953  C  CE2 . TRP A 1 145 ? -48.31896 12.43652 -0.86823  1.000 61.26000  ? 125 TRP A CE2 1 
ATOM   954  C  CE3 . TRP A 1 145 ? -49.99762 11.03958 -1.91007  1.000 60.39000  ? 125 TRP A CE3 1 
ATOM   955  C  CZ2 . TRP A 1 145 ? -49.24662 12.97024 0.01683   1.000 64.21000  ? 125 TRP A CZ2 1 
ATOM   956  C  CZ3 . TRP A 1 145 ? -50.91096 11.55633 -1.02848  1.000 65.97000  ? 125 TRP A CZ3 1 
ATOM   957  C  CH2 . TRP A 1 145 ? -50.53344 12.51849 -0.07874  1.000 59.89000  ? 125 TRP A CH2 1 
ATOM   958  N  N   . CYS A 1 146 ? -47.24846 7.23371  -4.96717  1.000 54.89000  ? 126 CYS A N   1 
ATOM   959  C  CA  . CYS A 1 146 ? -47.74183 6.38523  -6.05238  1.000 54.44000  ? 126 CYS A CA  1 
ATOM   960  C  C   . CYS A 1 146 ? -48.25791 5.04681  -5.54784  1.000 56.22000  ? 126 CYS A C   1 
ATOM   961  O  O   . CYS A 1 146 ? -49.08386 4.41881  -6.22741  1.000 58.86000  ? 126 CYS A O   1 
ATOM   962  C  CB  . CYS A 1 146 ? -46.66293 6.18307  -7.12050  1.000 49.51000  ? 126 CYS A CB  1 
ATOM   963  S  SG  . CYS A 1 146 ? -46.09626 7.75159  -7.80348  1.000 58.30000  ? 126 CYS A SG  1 
ATOM   964  N  N   . THR A 1 147 ? -47.81129 4.60831  -4.37167  1.000 58.30000  ? 127 THR A N   1 
ATOM   965  C  CA  . THR A 1 147 ? -48.35229 3.42191  -3.72126  1.000 62.74000  ? 127 THR A CA  1 
ATOM   966  C  C   . THR A 1 147 ? -49.35670 3.76827  -2.63631  1.000 66.10000  ? 127 THR A C   1 
ATOM   967  O  O   . THR A 1 147 ? -49.91844 2.86046  -2.00913  1.000 58.63000  ? 127 THR A O   1 
ATOM   968  C  CB  . THR A 1 147 ? -47.21945 2.56193  -3.14098  1.000 66.42000  ? 127 THR A CB  1 
ATOM   969  O  OG1 . THR A 1 147 ? -46.46917 3.32043  -2.18585  1.000 54.83000  ? 127 THR A OG1 1 
ATOM   970  C  CG2 . THR A 1 147 ? -46.29122 2.10049  -4.23728  1.000 60.77000  ? 127 THR A CG2 1 
ATOM   971  N  N   . GLY A 1 148 ? -49.58628 5.06012  -2.40059  1.000 62.82000  ? 128 GLY A N   1 
ATOM   972  C  CA  . GLY A 1 148 ? -50.67033 5.52353  -1.56664  1.000 51.05000  ? 128 GLY A CA  1 
ATOM   973  C  C   . GLY A 1 148 ? -52.02243 5.01091  -2.01549  1.000 65.13000  ? 128 GLY A C   1 
ATOM   974  O  O   . GLY A 1 148 ? -52.12585 4.19448  -2.93783  1.000 63.01000  ? 128 GLY A O   1 
ATOM   975  N  N   . ASP A 1 149 ? -53.07795 5.48766  -1.37381  1.000 64.34000  ? 129 ASP A N   1 
ATOM   976  C  CA  . ASP A 1 149 ? -54.43342 5.05989  -1.69334  1.000 69.11000  ? 129 ASP A CA  1 
ATOM   977  C  C   . ASP A 1 149 ? -55.20254 6.06159  -2.55819  1.000 68.13000  ? 129 ASP A C   1 
ATOM   978  O  O   . ASP A 1 149 ? -56.37453 5.81805  -2.86453  1.000 69.88000  ? 129 ASP A O   1 
ATOM   979  C  CB  . ASP A 1 149 ? -55.20676 4.79745  -0.39617  1.000 74.30000  ? 129 ASP A CB  1 
ATOM   980  C  CG  . ASP A 1 149 ? -55.32725 6.04620  0.45754   1.000 83.27000  ? 129 ASP A CG  1 
ATOM   981  O  OD1 . ASP A 1 149 ? -56.44339 6.60280  0.53430   1.000 98.23000  ? 129 ASP A OD1 1 
ATOM   982  O  OD2 . ASP A 1 149 ? -54.30013 6.48202  1.03381   1.000 88.32000  ? 129 ASP A OD2 1 
ATOM   983  N  N   . SER A 1 150 ? -54.58656 7.17903  -2.94900  1.000 70.18000  ? 130 SER A N   1 
ATOM   984  C  CA  . SER A 1 150 ? -55.21321 8.18150  -3.81415  1.000 65.86000  ? 130 SER A CA  1 
ATOM   985  C  C   . SER A 1 150 ? -54.54031 8.14198  -5.19004  1.000 64.11000  ? 130 SER A C   1 
ATOM   986  O  O   . SER A 1 150 ? -53.40437 8.60294  -5.34406  1.000 53.93000  ? 130 SER A O   1 
ATOM   987  C  CB  . SER A 1 150 ? -55.10594 9.57379  -3.18842  1.000 56.84000  ? 130 SER A CB  1 
ATOM   988  O  OG  . SER A 1 150 ? -55.50142 10.60835 -4.07434  1.000 61.55000  ? 130 SER A OG  1 
ATOM   989  N  N   . LEU A 1 151 ? -55.24668 7.60494  -6.18960  1.000 64.64000  ? 131 LEU A N   1 
ATOM   990  C  CA  . LEU A 1 151 ? -54.70461 7.58848  -7.54674  1.000 51.32000  ? 131 LEU A CA  1 
ATOM   991  C  C   . LEU A 1 151 ? -54.38340 8.99492  -8.02613  1.000 57.82000  ? 131 LEU A C   1 
ATOM   992  O  O   . LEU A 1 151 ? -53.30045 9.23625  -8.56599  1.000 57.04000  ? 131 LEU A O   1 
ATOM   993  C  CB  . LEU A 1 151 ? -55.68160 6.90891  -8.49922  1.000 53.35000  ? 131 LEU A CB  1 
ATOM   994  C  CG  . LEU A 1 151 ? -55.75046 5.38810  -8.34914  1.000 52.97000  ? 131 LEU A CG  1 
ATOM   995  C  CD1 . LEU A 1 151 ? -56.82299 4.80647  -9.24624  1.000 57.32000  ? 131 LEU A CD1 1 
ATOM   996  C  CD2 . LEU A 1 151 ? -54.39580 4.74781  -8.64125  1.000 55.68000  ? 131 LEU A CD2 1 
ATOM   997  N  N   . ALA A 1 152 ? -55.28317 9.95028  -7.77713  1.000 54.20000  ? 132 ALA A N   1 
ATOM   998  C  CA  . ALA A 1 152 ? -55.06118 11.30902 -8.25555  1.000 51.43000  ? 132 ALA A CA  1 
ATOM   999  C  C   . ALA A 1 152 ? -53.82662 11.93363 -7.63131  1.000 49.96000  ? 132 ALA A C   1 
ATOM   1000 O  O   . ALA A 1 152 ? -53.11011 12.69461 -8.28505  1.000 52.23000  ? 132 ALA A O   1 
ATOM   1001 C  CB  . ALA A 1 152 ? -56.29105 12.16677 -7.97490  1.000 60.86000  ? 132 ALA A CB  1 
ATOM   1002 N  N   . ALA A 1 153 ? -53.56843 11.64676 -6.35504  1.000 58.44000  ? 133 ALA A N   1 
ATOM   1003 C  CA  . ALA A 1 153 ? -52.39586 12.22443 -5.70257  1.000 51.11000  ? 133 ALA A CA  1 
ATOM   1004 C  C   . ALA A 1 153 ? -51.12237 11.57131 -6.20884  1.000 50.66000  ? 133 ALA A C   1 
ATOM   1005 O  O   . ALA A 1 153 ? -50.08866 12.23844 -6.35243  1.000 53.76000  ? 133 ALA A O   1 
ATOM   1006 C  CB  . ALA A 1 153 ? -52.50494 12.07268 -4.18842  1.000 55.51000  ? 133 ALA A CB  1 
ATOM   1007 N  N   . GLY A 1 154 ? -51.17642 10.26047 -6.45098  1.000 54.52000  ? 134 GLY A N   1 
ATOM   1008 C  CA  . GLY A 1 154 ? -50.10016 9.56772  -7.11994  1.000 58.26000  ? 134 GLY A CA  1 
ATOM   1009 C  C   . GLY A 1 154 ? -49.71037 10.30815 -8.38149  1.000 52.44000  ? 134 GLY A C   1 
ATOM   1010 O  O   . GLY A 1 154 ? -48.56978 10.75459 -8.52689  1.000 57.31000  ? 134 GLY A O   1 
ATOM   1011 N  N   . VAL A 1 155 ? -50.68020 10.49167 -9.27507  1.000 55.25000  ? 135 VAL A N   1 
ATOM   1012 C  CA  . VAL A 1 155 ? -50.41440 11.15685 -10.55318 1.000 52.37000  ? 135 VAL A CA  1 
ATOM   1013 C  C   . VAL A 1 155 ? -49.90499 12.56752 -10.31191 1.000 52.42000  ? 135 VAL A C   1 
ATOM   1014 O  O   . VAL A 1 155 ? -48.87562 12.97646 -10.85915 1.000 57.59000  ? 135 VAL A O   1 
ATOM   1015 C  CB  . VAL A 1 155 ? -51.67322 11.14012 -11.43691 1.000 50.55000  ? 135 VAL A CB  1 
ATOM   1016 C  CG1 . VAL A 1 155 ? -51.44706 11.92478 -12.70223 1.000 52.75000  ? 135 VAL A CG1 1 
ATOM   1017 C  CG2 . VAL A 1 155 ? -52.07387 9.71242  -11.74863 1.000 46.43000  ? 135 VAL A CG2 1 
ATOM   1018 N  N   . ALA A 1 156 ? -50.58189 13.30450 -9.42418  1.000 55.74000  ? 136 ALA A N   1 
ATOM   1019 C  CA  . ALA A 1 156 ? -50.18479 14.66875 -9.10202  1.000 56.24000  ? 136 ALA A CA  1 
ATOM   1020 C  C   . ALA A 1 156 ? -48.74224 14.75068 -8.61986  1.000 53.64000  ? 136 ALA A C   1 
ATOM   1021 O  O   . ALA A 1 156 ? -48.06644 15.75544 -8.87468  1.000 52.31000  ? 136 ALA A O   1 
ATOM   1022 C  CB  . ALA A 1 156 ? -51.13668 15.24169 -8.04387  1.000 54.09000  ? 136 ALA A CB  1 
ATOM   1023 N  N   . ALA A 1 157 ? -48.26064 13.71822 -7.90952  1.000 50.41000  ? 137 ALA A N   1 
ATOM   1024 C  CA  . ALA A 1 157 ? -46.88634 13.72795 -7.41376  1.000 57.16000  ? 137 ALA A CA  1 
ATOM   1025 C  C   . ALA A 1 157 ? -45.89452 13.63374 -8.56445  1.000 58.13000  ? 137 ALA A C   1 
ATOM   1026 O  O   . ALA A 1 157 ? -44.88978 14.35291 -8.59136  1.000 59.28000  ? 137 ALA A O   1 
ATOM   1027 C  CB  . ALA A 1 157 ? -46.67128 12.58404 -6.43026  1.000 49.92000  ? 137 ALA A CB  1 
ATOM   1028 N  N   . LEU A 1 158 ? -46.16056 12.74692 -9.52264  1.000 57.15000  ? 138 LEU A N   1 
ATOM   1029 C  CA  . LEU A 1 158 ? -45.37647 12.72817 -10.74432 1.000 56.56000  ? 138 LEU A CA  1 
ATOM   1030 C  C   . LEU A 1 158 ? -45.54814 14.02868 -11.51090 1.000 56.37000  ? 138 LEU A C   1 
ATOM   1031 O  O   . LEU A 1 158 ? -44.56558 14.60369 -11.98780 1.000 54.85000  ? 138 LEU A O   1 
ATOM   1032 C  CB  . LEU A 1 158 ? -45.79050 11.53089 -11.59476 1.000 52.32000  ? 138 LEU A CB  1 
ATOM   1033 C  CG  . LEU A 1 158 ? -45.67266 10.17093 -10.89133 1.000 59.19000  ? 138 LEU A CG  1 
ATOM   1034 C  CD1 . LEU A 1 158 ? -46.15490 9.05593  -11.79925 1.000 48.65000  ? 138 LEU A CD1 1 
ATOM   1035 C  CD2 . LEU A 1 158 ? -44.25775 9.91520  -10.48408 1.000 52.14000  ? 138 LEU A CD2 1 
ATOM   1036 N  N   . TYR A 1 159 ? -46.78350 14.52995 -11.60476 1.000 55.16000  ? 139 TYR A N   1 
ATOM   1037 C  CA  . TYR A 1 159 ? -47.03150 15.73976 -12.38540 1.000 51.32000  ? 139 TYR A CA  1 
ATOM   1038 C  C   . TYR A 1 159 ? -46.20919 16.92258 -11.88073 1.000 57.03000  ? 139 TYR A C   1 
ATOM   1039 O  O   . TYR A 1 159 ? -45.78138 17.76639 -12.68031 1.000 56.37000  ? 139 TYR A O   1 
ATOM   1040 C  CB  . TYR A 1 159 ? -48.52322 16.08242 -12.37119 1.000 49.10000  ? 139 TYR A CB  1 
ATOM   1041 C  CG  . TYR A 1 159 ? -48.84400 17.41980 -13.00696 1.000 54.20000  ? 139 TYR A CG  1 
ATOM   1042 C  CD1 . TYR A 1 159 ? -48.70351 18.61052 -12.30013 1.000 58.91000  ? 139 TYR A CD1 1 
ATOM   1043 C  CD2 . TYR A 1 159 ? -49.27539 17.49643 -14.33116 1.000 58.98000  ? 139 TYR A CD2 1 
ATOM   1044 C  CE1 . TYR A 1 159 ? -48.97962 19.82751 -12.87527 1.000 54.16000  ? 139 TYR A CE1 1 
ATOM   1045 C  CE2 . TYR A 1 159 ? -49.57065 18.72212 -14.92067 1.000 61.70000  ? 139 TYR A CE2 1 
ATOM   1046 C  CZ  . TYR A 1 159 ? -49.41678 19.87799 -14.17987 1.000 61.90000  ? 139 TYR A CZ  1 
ATOM   1047 O  OH  . TYR A 1 159 ? -49.69485 21.09633 -14.73276 1.000 53.24000  ? 139 TYR A OH  1 
ATOM   1048 N  N   . SER A 1 160 ? -46.02507 17.03348 -10.55107 1.000 58.82000  ? 140 SER A N   1 
ATOM   1049 C  CA  . SER A 1 160 ? -45.23203 18.12174 -9.98410  1.000 57.03000  ? 140 SER A CA  1 
ATOM   1050 C  C   . SER A 1 160 ? -43.75612 17.97086 -10.29863 1.000 57.37000  ? 140 SER A C   1 
ATOM   1051 O  O   . SER A 1 160 ? -42.99317 18.92222 -10.11160 1.000 58.26000  ? 140 SER A O   1 
ATOM   1052 C  CB  . SER A 1 160 ? -45.40144 18.20685 -8.45351  1.000 55.28000  ? 140 SER A CB  1 
ATOM   1053 O  OG  . SER A 1 160 ? -46.75311 18.13052 -8.05427  1.000 56.41000  ? 140 SER A OG  1 
ATOM   1054 N  N   . TYR A 1 161 ? -43.32923 16.77800 -10.70200 1.000 55.51000  ? 141 TYR A N   1 
ATOM   1055 C  CA  . TYR A 1 161 ? -41.98629 16.60767 -11.24225 1.000 61.67000  ? 141 TYR A CA  1 
ATOM   1056 C  C   . TYR A 1 161 ? -41.94799 16.93554 -12.73588 1.000 57.56000  ? 141 TYR A C   1 
ATOM   1057 O  O   . TYR A 1 161 ? -41.19005 17.81338 -13.16811 1.000 59.52000  ? 141 TYR A O   1 
ATOM   1058 C  CB  . TYR A 1 161 ? -41.49247 15.17855 -10.98096 1.000 65.13000  ? 141 TYR A CB  1 
ATOM   1059 C  CG  . TYR A 1 161 ? -40.09025 14.93631 -11.49668 1.000 69.57000  ? 141 TYR A CG  1 
ATOM   1060 C  CD1 . TYR A 1 161 ? -38.99619 15.53960 -10.88978 1.000 67.24000  ? 141 TYR A CD1 1 
ATOM   1061 C  CD2 . TYR A 1 161 ? -39.85823 14.10554 -12.58513 1.000 66.22000  ? 141 TYR A CD2 1 
ATOM   1062 C  CE1 . TYR A 1 161 ? -37.71216 15.33408 -11.34530 1.000 67.60000  ? 141 TYR A CE1 1 
ATOM   1063 C  CE2 . TYR A 1 161 ? -38.56710 13.88473 -13.04366 1.000 72.95000  ? 141 TYR A CE2 1 
ATOM   1064 C  CZ  . TYR A 1 161 ? -37.50252 14.50291 -12.41500 1.000 73.21000  ? 141 TYR A CZ  1 
ATOM   1065 O  OH  . TYR A 1 161 ? -36.22598 14.29830 -12.86572 1.000 79.13000  ? 141 TYR A OH  1 
ATOM   1066 N  N   . GLU A 1 162 ? -42.81067 16.28564 -13.52490 1.000 57.44000  ? 142 GLU A N   1 
ATOM   1067 C  CA  . GLU A 1 162 ? -42.66584 16.32622 -14.97852 1.000 62.93000  ? 142 GLU A CA  1 
ATOM   1068 C  C   . GLU A 1 162 ? -42.92658 17.72050 -15.54869 1.000 67.70000  ? 142 GLU A C   1 
ATOM   1069 O  O   . GLU A 1 162 ? -42.19391 18.14706 -16.44117 1.000 67.85000  ? 142 GLU A O   1 
ATOM   1070 C  CB  . GLU A 1 162 ? -43.56944 15.27997 -15.62786 1.000 59.51000  ? 142 GLU A CB  1 
ATOM   1071 C  CG  . GLU A 1 162 ? -43.35677 13.85482 -15.10623 1.000 61.34000  ? 142 GLU A CG  1 
ATOM   1072 C  CD  . GLU A 1 162 ? -43.43372 12.78156 -16.18457 1.000 63.18000  ? 142 GLU A CD  1 
ATOM   1073 O  OE1 . GLU A 1 162 ? -42.84401 12.95917 -17.25998 1.000 73.01000  ? 142 GLU A OE1 1 
ATOM   1074 O  OE2 . GLU A 1 162 ? -44.09807 11.75608 -15.96194 1.000 64.00000  ? 142 GLU A OE2 1 
ATOM   1075 N  N   . SER A 1 163 ? -43.92490 18.46912 -15.03006 1.000 62.15000  ? 143 SER A N   1 
ATOM   1076 C  CA  . SER A 1 163 ? -44.22127 19.78623 -15.60928 1.000 59.98000  ? 143 SER A CA  1 
ATOM   1077 C  C   . SER A 1 163 ? -43.05707 20.75675 -15.45499 1.000 59.96000  ? 143 SER A C   1 
ATOM   1078 O  O   . SER A 1 163 ? -42.98364 21.73727 -16.19936 1.000 60.78000  ? 143 SER A O   1 
ATOM   1079 C  CB  . SER A 1 163 ? -45.49850 20.41778 -15.00714 0.826 31.63000  ? 143 SER A CB  1 
ATOM   1080 O  OG  . SER A 1 163 ? -45.23363 21.15052 -13.80830 0.450 31.63000  ? 143 SER A OG  1 
ATOM   1081 N  N   . GLN A 1 164 ? -42.13771 20.50116 -14.51982 1.000 65.27000  ? 144 GLN A N   1 
ATOM   1082 C  CA  . GLN A 1 164 ? -40.94644 21.33485 -14.39244 1.000 61.02000  ? 144 GLN A CA  1 
ATOM   1083 C  C   . GLN A 1 164 ? -39.90870 21.03193 -15.47046 1.000 66.22000  ? 144 GLN A C   1 
ATOM   1084 O  O   . GLN A 1 164 ? -39.09538 21.89755 -15.81013 1.000 65.26000  ? 144 GLN A O   1 
ATOM   1085 C  CB  . GLN A 1 164 ? -40.32247 21.12990 -13.00725 1.000 64.53000  ? 144 GLN A CB  1 
ATOM   1086 C  CG  . GLN A 1 164 ? -41.19331 21.59434 -11.85637 1.000 63.72000  ? 144 GLN A CG  1 
ATOM   1087 C  CD  . GLN A 1 164 ? -40.46688 21.58498 -10.51746 1.000 68.22000  ? 144 GLN A CD  1 
ATOM   1088 O  OE1 . GLN A 1 164 ? -39.51176 22.33125 -10.31782 1.000 68.91000  ? 144 GLN A OE1 1 
ATOM   1089 N  NE2 . GLN A 1 164 ? -40.93359 20.74743 -9.58504  1.000 56.26000  ? 144 GLN A NE2 1 
ATOM   1090 N  N   . ILE A 1 165 ? -39.91053 19.81615 -16.00376 1.000 69.05000  ? 145 ILE A N   1 
ATOM   1091 C  CA  . ILE A 1 165 ? -38.77239 19.31110 -16.77119 1.000 71.00000  ? 145 ILE A CA  1 
ATOM   1092 C  C   . ILE A 1 165 ? -38.60924 19.99208 -18.13042 1.000 67.34000  ? 145 ILE A C   1 
ATOM   1093 O  O   . ILE A 1 165 ? -37.48361 20.39187 -18.45499 1.000 71.39000  ? 145 ILE A O   1 
ATOM   1094 C  CB  . ILE A 1 165 ? -38.84858 17.78664 -16.93765 1.000 70.04000  ? 145 ILE A CB  1 
ATOM   1095 C  CG1 . ILE A 1 165 ? -38.55345 17.06969 -15.61725 1.000 66.31000  ? 145 ILE A CG1 1 
ATOM   1096 C  CG2 . ILE A 1 165 ? -37.85718 17.33544 -17.99335 1.000 77.09000  ? 145 ILE A CG2 1 
ATOM   1097 C  CD1 . ILE A 1 165 ? -37.60758 17.81453 -14.70580 1.000 67.04000  ? 145 ILE A CD1 1 
ATOM   1098 N  N   . PRO A 1 166 ? -39.65748 20.15827 -18.95197 1.000 70.56000  ? 146 PRO A N   1 
ATOM   1099 C  CA  . PRO A 1 166 ? -39.45277 20.84358 -20.24127 1.000 68.28000  ? 146 PRO A CA  1 
ATOM   1100 C  C   . PRO A 1 166 ? -38.66516 22.13351 -20.12850 1.000 75.16000  ? 146 PRO A C   1 
ATOM   1101 O  O   . PRO A 1 166 ? -37.71233 22.33775 -20.88579 1.000 75.68000  ? 146 PRO A O   1 
ATOM   1102 C  CB  . PRO A 1 166 ? -40.88616 21.08694 -20.72448 1.000 65.81000  ? 146 PRO A CB  1 
ATOM   1103 C  CG  . PRO A 1 166 ? -41.65493 19.98678 -20.15172 1.000 67.10000  ? 146 PRO A CG  1 
ATOM   1104 C  CD  . PRO A 1 166 ? -41.07687 19.79295 -18.78154 1.000 69.85000  ? 146 PRO A CD  1 
ATOM   1105 N  N   . ARG A 1 167 ? -39.02127 23.00266 -19.18732 1.000 74.14000  ? 147 ARG A N   1 
ATOM   1106 C  CA  . ARG A 1 167 ? -38.25774 24.23071 -18.99852 1.000 74.92000  ? 147 ARG A CA  1 
ATOM   1107 C  C   . ARG A 1 167 ? -36.84514 23.94114 -18.48003 1.000 75.59000  ? 147 ARG A C   1 
ATOM   1108 O  O   . ARG A 1 167 ? -35.88110 24.57543 -18.92320 1.000 75.31000  ? 147 ARG A O   1 
ATOM   1109 C  CB  . ARG A 1 167 ? -39.02002 25.16737 -18.05410 1.000 83.77000  ? 147 ARG A CB  1 
ATOM   1110 C  CG  . ARG A 1 167 ? -39.00017 26.63483 -18.46454 1.000 87.04000  ? 147 ARG A CG  1 
ATOM   1111 N  N   . ILE A 1 168 ? -36.69795 22.97739 -17.55684 1.000 76.93000  ? 148 ILE A N   1 
ATOM   1112 C  CA  . ILE A 1 168 ? -35.38423 22.67658 -16.97707 1.000 74.64000  ? 148 ILE A CA  1 
ATOM   1113 C  C   . ILE A 1 168 ? -34.42900 22.16834 -18.04627 1.000 76.31000  ? 148 ILE A C   1 
ATOM   1114 O  O   . ILE A 1 168 ? -33.26644 22.58249 -18.11378 1.000 78.04000  ? 148 ILE A O   1 
ATOM   1115 C  CB  . ILE A 1 168 ? -35.50463 21.65907 -15.82511 1.000 78.64000  ? 148 ILE A CB  1 
ATOM   1116 C  CG1 . ILE A 1 168 ? -36.15586 22.28944 -14.59378 1.000 77.65000  ? 148 ILE A CG1 1 
ATOM   1117 N  N   . ALA A 1 169 ? -34.90013 21.24071 -18.88115 1.000 77.57000  ? 149 ALA A N   1 
ATOM   1118 C  CA  . ALA A 1 169 ? -34.04589 20.64825 -19.90921 1.000 82.70000  ? 149 ALA A CA  1 
ATOM   1119 C  C   . ALA A 1 169 ? -33.42956 21.71066 -20.81482 1.000 80.16000  ? 149 ALA A C   1 
ATOM   1120 O  O   . ALA A 1 169 ? -32.22732 21.67050 -21.10527 1.000 83.73000  ? 149 ALA A O   1 
ATOM   1121 C  CB  . ALA A 1 169 ? -34.84908 19.64332 -20.73778 1.000 75.59000  ? 149 ALA A CB  1 
ATOM   1122 N  N   . ARG A 1 170 ? -34.24037 22.66680 -21.26416 1.000 74.76000  ? 150 ARG A N   1 
ATOM   1123 C  CA  . ARG A 1 170 ? -33.74872 23.75050 -22.10603 1.000 81.88000  ? 150 ARG A CA  1 
ATOM   1124 C  C   . ARG A 1 170 ? -32.58549 24.48481 -21.44896 1.000 84.36000  ? 150 ARG A C   1 
ATOM   1125 O  O   . ARG A 1 170 ? -31.51445 24.63953 -22.04526 1.000 81.19000  ? 150 ARG A O   1 
ATOM   1126 C  CB  . ARG A 1 170 ? -34.89151 24.71565 -22.39919 0.475 30.00000  ? 150 ARG A CB  1 
ATOM   1127 C  CG  . ARG A 1 170 ? -34.90511 25.26646 -23.78977 0.578 30.00000  ? 150 ARG A CG  1 
ATOM   1128 C  CD  . ARG A 1 170 ? -36.16432 26.07921 -23.97471 0.638 30.00000  ? 150 ARG A CD  1 
ATOM   1129 N  NE  . ARG A 1 170 ? -35.91454 27.27002 -24.77285 0.474 30.00000  ? 150 ARG A NE  1 
ATOM   1130 C  CZ  . ARG A 1 170 ? -35.52892 28.42200 -24.25525 0.401 30.00000  ? 150 ARG A CZ  1 
ATOM   1131 N  NH1 . ARG A 1 170 ? -35.32182 28.55586 -22.95365 0.228 30.00000  ? 150 ARG A NH1 1 
ATOM   1132 N  NH2 . ARG A 1 170 ? -35.34781 29.46827 -25.05733 0.509 30.00000  ? 150 ARG A NH2 1 
ATOM   1133 N  N   . GLU A 1 171 ? -32.78587 24.96569 -20.22329 1.000 87.49000  ? 151 GLU A N   1 
ATOM   1134 C  CA  . GLU A 1 171 ? -31.70210 25.63812 -19.51351 1.000 89.31000  ? 151 GLU A CA  1 
ATOM   1135 C  C   . GLU A 1 171 ? -30.52453 24.69098 -19.27784 1.000 88.63000  ? 151 GLU A C   1 
ATOM   1136 O  O   . GLU A 1 171 ? -29.36298 25.10296 -19.36819 1.000 88.66000  ? 151 GLU A O   1 
ATOM   1137 C  CB  . GLU A 1 171 ? -32.22714 26.21670 -18.19288 1.000 82.46000  ? 151 GLU A CB  1 
ATOM   1138 C  CG  . GLU A 1 171 ? -31.30021 27.22660 -17.47876 1.000 93.33000  ? 151 GLU A CG  1 
ATOM   1139 C  CD  . GLU A 1 171 ? -30.82480 28.38767 -18.36260 1.000 98.64000  ? 151 GLU A CD  1 
ATOM   1140 O  OE1 . GLU A 1 171 ? -31.63044 28.93518 -19.15124 1.000 92.27000  ? 151 GLU A OE1 1 
ATOM   1141 O  OE2 . GLU A 1 171 ? -29.63902 28.76504 -18.24439 1.000 99.35000  ? 151 GLU A OE2 1 
ATOM   1142 N  N   . LYS A 1 172 ? -30.80063 23.41305 -18.99860 1.000 85.81000  ? 152 LYS A N   1 
ATOM   1143 C  CA  . LYS A 1 172 ? -29.72061 22.45498 -18.77557 1.000 83.35000  ? 152 LYS A CA  1 
ATOM   1144 C  C   . LYS A 1 172 ? -28.80419 22.36395 -19.99172 1.000 84.98000  ? 152 LYS A C   1 
ATOM   1145 O  O   . LYS A 1 172 ? -27.58077 22.49154 -19.87040 1.000 82.45000  ? 152 LYS A O   1 
ATOM   1146 C  CB  . LYS A 1 172 ? -30.29956 21.08389 -18.42288 1.000 83.76000  ? 152 LYS A CB  1 
ATOM   1147 N  N   . ILE A 1 173 ? -29.38718 22.16549 -21.17707 1.000 82.90000  ? 153 ILE A N   1 
ATOM   1148 C  CA  . ILE A 1 173 ? -28.60244 22.07159 -22.40476 1.000 78.54000  ? 153 ILE A CA  1 
ATOM   1149 C  C   . ILE A 1 173 ? -27.84189 23.36590 -22.66279 1.000 88.68000  ? 153 ILE A C   1 
ATOM   1150 O  O   . ILE A 1 173 ? -26.67222 23.34490 -23.06410 1.000 88.74000  ? 153 ILE A O   1 
ATOM   1151 C  CB  . ILE A 1 173 ? -29.51046 21.72847 -23.59756 1.000 77.72000  ? 153 ILE A CB  1 
ATOM   1152 C  CG1 . ILE A 1 173 ? -29.95592 20.28035 -23.55420 1.000 72.82000  ? 153 ILE A CG1 1 
ATOM   1153 C  CG2 . ILE A 1 173 ? -28.78390 21.97698 -24.90707 1.000 87.88000  ? 153 ILE A CG2 1 
ATOM   1154 C  CD1 . ILE A 1 173 ? -31.29709 20.07155 -24.20835 1.000 73.48000  ? 153 ILE A CD1 1 
ATOM   1155 N  N   . ARG A 1 174 ? -28.49643 24.51121 -22.46271 1.000 87.00000  ? 154 ARG A N   1 
ATOM   1156 C  CA  . ARG A 1 174 ? -27.85135 25.79338 -22.73016 1.000 88.98000  ? 154 ARG A CA  1 
ATOM   1157 C  C   . ARG A 1 174 ? -26.56539 25.94247 -21.92929 1.000 87.39000  ? 154 ARG A C   1 
ATOM   1158 O  O   . ARG A 1 174 ? -25.49331 26.20359 -22.48574 1.000 93.85000  ? 154 ARG A O   1 
ATOM   1159 C  CB  . ARG A 1 174 ? -28.80147 26.94315 -22.40751 1.000 92.14000  ? 154 ARG A CB  1 
ATOM   1160 C  CG  . ARG A 1 174 ? -28.12085 28.29670 -22.48390 1.000 93.84000  ? 154 ARG A CG  1 
ATOM   1161 C  CD  . ARG A 1 174 ? -28.95375 29.39443 -21.84171 1.000 95.40000  ? 154 ARG A CD  1 
ATOM   1162 N  NE  . ARG A 1 174 ? -28.11122 30.39254 -21.19260 1.000 99.00000  ? 154 ARG A NE  1 
ATOM   1163 C  CZ  . ARG A 1 174 ? -27.40119 30.17697 -20.09243 1.000 96.54000  ? 154 ARG A CZ  1 
ATOM   1164 N  NH1 . ARG A 1 174 ? -27.42675 29.01076 -19.47021 1.000 95.87000  ? 154 ARG A NH1 1 
ATOM   1165 N  NH2 . ARG A 1 174 ? -26.64808 31.15848 -19.60141 1.000 99.95000  ? 154 ARG A NH2 1 
ATOM   1166 N  N   . GLY A 1 175 ? -26.65714 25.78560 -20.61177 1.000 87.06000  ? 155 GLY A N   1 
ATOM   1167 C  CA  . GLY A 1 175 ? -25.47652 25.89462 -19.77896 1.000 91.35000  ? 155 GLY A CA  1 
ATOM   1168 C  C   . GLY A 1 175 ? -24.42808 24.85034 -20.08023 1.000 95.63000  ? 155 GLY A C   1 
ATOM   1169 O  O   . GLY A 1 175 ? -23.25830 25.04160 -19.74285 1.000 99.81000  ? 155 GLY A O   1 
ATOM   1170 N  N   . LEU A 1 176 ? -24.81689 23.75472 -20.72745 1.000 95.46000  ? 156 LEU A N   1 
ATOM   1171 C  CA  . LEU A 1 176 ? -23.86817 22.68713 -21.02343 1.000 96.20000  ? 156 LEU A CA  1 
ATOM   1172 C  C   . LEU A 1 176 ? -22.87984 23.11160 -22.10622 1.000 96.70000  ? 156 LEU A C   1 
ATOM   1173 O  O   . LEU A 1 176 ? -21.66993 22.88959 -21.97899 1.000 100.92000 ? 156 LEU A O   1 
ATOM   1174 C  CB  . LEU A 1 176 ? -24.62823 21.43284 -21.44717 1.000 92.35000  ? 156 LEU A CB  1 
ATOM   1175 C  CG  . LEU A 1 176 ? -25.04915 20.47231 -20.33696 1.000 90.22000  ? 156 LEU A CG  1 
ATOM   1176 C  CD1 . LEU A 1 176 ? -25.64308 19.21670 -20.95225 1.000 88.84000  ? 156 LEU A CD1 1 
ATOM   1177 C  CD2 . LEU A 1 176 ? -23.89942 20.14819 -19.39611 1.000 86.23000  ? 156 LEU A CD2 1 
ATOM   1178 N  N   . THR A 1 177 ? -23.37572 23.73610 -23.17220 1.000 90.18000  ? 157 THR A N   1 
ATOM   1179 C  CA  . THR A 1 177 ? -22.53782 24.12376 -24.29777 1.000 94.36000  ? 157 THR A CA  1 
ATOM   1180 C  C   . THR A 1 177 ? -21.93130 25.51792 -24.13509 1.000 93.67000  ? 157 THR A C   1 
ATOM   1181 O  O   . THR A 1 177 ? -20.96644 25.84784 -24.83615 1.000 96.19000  ? 157 THR A O   1 
ATOM   1182 C  CB  . THR A 1 177 ? -23.35461 24.04522 -25.59275 1.000 101.09000 ? 157 THR A CB  1 
ATOM   1183 O  OG1 . THR A 1 177 ? -24.54837 24.81927 -25.44626 1.000 95.18000  ? 157 THR A OG1 1 
ATOM   1184 C  CG2 . THR A 1 177 ? -23.76659 22.60334 -25.88395 1.000 98.25000  ? 157 THR A CG2 1 
ATOM   1185 N  N   . GLU A 1 178 ? -22.49022 26.35125 -23.24449 1.000 30.00000  ? 158 GLU A N   1 
ATOM   1186 C  CA  . GLU A 1 178 ? -21.76423 27.49362 -22.68161 1.000 30.00000  ? 158 GLU A CA  1 
ATOM   1187 C  C   . GLU A 1 178 ? -20.66456 26.93162 -21.79265 1.000 30.00000  ? 158 GLU A C   1 
ATOM   1188 O  O   . GLU A 1 178 ? -19.68743 26.38042 -22.33166 1.000 30.00000  ? 158 GLU A O   1 
ATOM   1189 C  CB  . GLU A 1 178 ? -22.69764 28.44971 -21.88193 1.000 30.00000  ? 158 GLU A CB  1 
ATOM   1190 N  N   . TYR A 1 179 ? -20.83728 26.96142 -20.47942 1.000 94.79000  ? 159 TYR A N   1 
ATOM   1191 C  CA  . TYR A 1 179 ? -19.70243 26.96180 -19.57071 1.000 99.85000  ? 159 TYR A CA  1 
ATOM   1192 C  C   . TYR A 1 179 ? -19.03086 25.59988 -19.40558 1.000 99.18000  ? 159 TYR A C   1 
ATOM   1193 O  O   . TYR A 1 179 ? -17.90568 25.54971 -18.89252 1.000 101.06000 ? 159 TYR A O   1 
ATOM   1194 C  CB  . TYR A 1 179 ? -20.14864 27.48724 -18.20373 1.000 98.20000  ? 159 TYR A CB  1 
ATOM   1195 C  CG  . TYR A 1 179 ? -21.19771 28.58418 -18.27817 1.000 102.04000 ? 159 TYR A CG  1 
ATOM   1196 C  CD1 . TYR A 1 179 ? -22.52774 28.28940 -18.58292 1.000 99.85000  ? 159 TYR A CD1 1 
ATOM   1197 C  CD2 . TYR A 1 179 ? -20.85638 29.91615 -18.08298 1.000 102.01000 ? 159 TYR A CD2 1 
ATOM   1198 C  CE1 . TYR A 1 179 ? -23.48285 29.27777 -18.66370 1.000 101.31000 ? 159 TYR A CE1 1 
ATOM   1199 C  CE2 . TYR A 1 179 ? -21.81057 30.91594 -18.17028 1.000 103.96000 ? 159 TYR A CE2 1 
ATOM   1200 C  CZ  . TYR A 1 179 ? -23.11839 30.58876 -18.45840 1.000 105.67000 ? 159 TYR A CZ  1 
ATOM   1201 O  OH  . TYR A 1 179 ? -24.06785 31.57779 -18.54255 1.000 108.06000 ? 159 TYR A OH  1 
ATOM   1202 N  N   . PHE A 1 180 ? -19.67408 24.49867 -19.81168 1.000 95.73000  ? 160 PHE A N   1 
ATOM   1203 C  CA  . PHE A 1 180 ? -19.08391 23.16966 -19.64905 1.000 96.62000  ? 160 PHE A CA  1 
ATOM   1204 C  C   . PHE A 1 180 ? -18.78491 22.48844 -20.97827 1.000 97.80000  ? 160 PHE A C   1 
ATOM   1205 O  O   . PHE A 1 180 ? -18.61596 21.26326 -21.01180 1.000 93.87000  ? 160 PHE A O   1 
ATOM   1206 C  CB  . PHE A 1 180 ? -19.96174 22.26032 -18.78434 1.000 98.00000  ? 160 PHE A CB  1 
ATOM   1207 C  CG  . PHE A 1 180 ? -20.51815 22.93288 -17.55876 1.000 100.75000 ? 160 PHE A CG  1 
ATOM   1208 C  CD1 . PHE A 1 180 ? -21.68882 23.66648 -17.62261 1.000 100.73000 ? 160 PHE A CD1 1 
ATOM   1209 C  CD2 . PHE A 1 180 ? -19.85474 22.84139 -16.33788 1.000 99.25000  ? 160 PHE A CD2 1 
ATOM   1210 C  CE1 . PHE A 1 180 ? -22.19443 24.29254 -16.49887 1.000 97.53000  ? 160 PHE A CE1 1 
ATOM   1211 C  CE2 . PHE A 1 180 ? -20.35523 23.46997 -15.20834 1.000 98.38000  ? 160 PHE A CE2 1 
ATOM   1212 C  CZ  . PHE A 1 180 ? -21.52450 24.19719 -15.29000 1.000 97.32000  ? 160 PHE A CZ  1 
ATOM   1213 N  N   . GLY A 1 181 ? -18.71371 23.26354 -22.06437 1.000 99.22000  ? 161 GLY A N   1 
ATOM   1214 C  CA  . GLY A 1 181 ? -18.24096 22.80391 -23.35753 1.000 91.96000  ? 161 GLY A CA  1 
ATOM   1215 C  C   . GLY A 1 181 ? -18.69612 21.41943 -23.76598 1.000 98.99000  ? 161 GLY A C   1 
ATOM   1216 O  O   . GLY A 1 181 ? -18.01530 20.42626 -23.48352 1.000 97.75000  ? 161 GLY A O   1 
ATOM   1217 N  N   . PHE A 1 182 ? -19.84538 21.34298 -24.43126 1.000 96.63000  ? 162 PHE A N   1 
ATOM   1218 C  CA  . PHE A 1 182 ? -20.40500 20.08389 -24.91173 1.000 93.39000  ? 162 PHE A CA  1 
ATOM   1219 C  C   . PHE A 1 182 ? -20.48377 20.19835 -26.42483 1.000 96.92000  ? 162 PHE A C   1 
ATOM   1220 O  O   . PHE A 1 182 ? -21.41014 20.80599 -26.97215 1.000 95.20000  ? 162 PHE A O   1 
ATOM   1221 C  CB  . PHE A 1 182 ? -21.76655 19.81211 -24.29116 1.000 94.02000  ? 162 PHE A CB  1 
ATOM   1222 C  CG  . PHE A 1 182 ? -21.74632 18.76991 -23.20446 1.000 91.30000  ? 162 PHE A CG  1 
ATOM   1223 C  CD1 . PHE A 1 182 ? -21.44121 19.12416 -21.89815 1.000 86.47000  ? 162 PHE A CD1 1 
ATOM   1224 C  CD2 . PHE A 1 182 ? -22.09218 17.46298 -23.46316 1.000 93.74000  ? 162 PHE A CD2 1 
ATOM   1225 C  CE1 . PHE A 1 182 ? -21.43091 18.18197 -20.88283 1.000 84.46000  ? 162 PHE A CE1 1 
ATOM   1226 C  CE2 . PHE A 1 182 ? -22.09584 16.51938 -22.43519 1.000 90.56000  ? 162 PHE A CE2 1 
ATOM   1227 C  CZ  . PHE A 1 182 ? -21.76549 16.87812 -21.15959 1.000 87.85000  ? 162 PHE A CZ  1 
ATOM   1228 N  N   . SER A 1 183 ? -19.48050 19.64034 -27.09018 1.000 100.58000 ? 163 SER A N   1 
ATOM   1229 C  CA  . SER A 1 183 ? -19.46563 19.65828 -28.54260 1.000 97.06000  ? 163 SER A CA  1 
ATOM   1230 C  C   . SER A 1 183 ? -20.57712 18.78474 -29.10268 1.000 99.46000  ? 163 SER A C   1 
ATOM   1231 O  O   . SER A 1 183 ? -21.38090 19.24219 -29.91912 1.000 94.62000  ? 163 SER A O   1 
ATOM   1232 C  CB  . SER A 1 183 ? -18.10346 19.19292 -29.05499 1.000 95.89000  ? 163 SER A CB  1 
ATOM   1233 N  N   . ASN A 1 184 ? -20.65564 17.52977 -28.65272 1.000 100.77000 ? 164 ASN A N   1 
ATOM   1234 C  CA  . ASN A 1 184 ? -21.47175 16.52732 -29.32700 1.000 97.00000  ? 164 ASN A CA  1 
ATOM   1235 C  C   . ASN A 1 184 ? -22.86398 16.53509 -28.70520 1.000 97.42000  ? 164 ASN A C   1 
ATOM   1236 O  O   . ASN A 1 184 ? -22.98382 16.37435 -27.48308 1.000 92.12000  ? 164 ASN A O   1 
ATOM   1237 C  CB  . ASN A 1 184 ? -20.83108 15.15251 -29.18107 1.000 94.24000  ? 164 ASN A CB  1 
ATOM   1238 C  CG  . ASN A 1 184 ? -21.75821 14.00302 -29.58306 1.000 97.79000  ? 164 ASN A CG  1 
ATOM   1239 O  OD1 . ASN A 1 184 ? -22.84832 14.21179 -30.12616 1.000 96.01000  ? 164 ASN A OD1 1 
ATOM   1240 N  ND2 . ASN A 1 184 ? -21.35664 12.77992 -29.23376 1.000 98.71000  ? 164 ASN A ND2 1 
ATOM   1241 N  N   . PRO A 1 185 ? -23.92926 16.75087 -29.48193 1.000 93.40000  ? 165 PRO A N   1 
ATOM   1242 C  CA  . PRO A 1 185 ? -25.27794 16.71179 -28.89196 1.000 93.13000  ? 165 PRO A CA  1 
ATOM   1243 C  C   . PRO A 1 185 ? -25.67280 15.35552 -28.33378 1.000 94.45000  ? 165 PRO A C   1 
ATOM   1244 O  O   . PRO A 1 185 ? -26.36661 15.29482 -27.31305 1.000 91.68000  ? 165 PRO A O   1 
ATOM   1245 C  CB  . PRO A 1 185 ? -26.19131 17.10841 -30.06150 1.000 92.99000  ? 165 PRO A CB  1 
ATOM   1246 C  CG  . PRO A 1 185 ? -25.29352 17.63416 -31.14385 1.000 105.04000 ? 165 PRO A CG  1 
ATOM   1247 C  CD  . PRO A 1 185 ? -23.87779 17.61486 -30.66864 1.000 99.44000  ? 165 PRO A CD  1 
ATOM   1248 N  N   . GLU A 1 186 ? -25.27717 14.26137 -28.98112 1.000 89.78000  ? 166 GLU A N   1 
ATOM   1249 C  CA  . GLU A 1 186 ? -25.66717 12.94320 -28.49868 1.000 90.66000  ? 166 GLU A CA  1 
ATOM   1250 C  C   . GLU A 1 186 ? -25.23503 12.70359 -27.06046 1.000 90.68000  ? 166 GLU A C   1 
ATOM   1251 O  O   . GLU A 1 186 ? -25.69871 11.74370 -26.43573 1.000 90.30000  ? 166 GLU A O   1 
ATOM   1252 C  CB  . GLU A 1 186 ? -25.08936 11.86379 -29.41817 1.000 87.50000  ? 166 GLU A CB  1 
ATOM   1253 N  N   . ASP A 1 187 ? -24.36129 13.55083 -26.52552 1.000 88.51000  ? 167 ASP A N   1 
ATOM   1254 C  CA  . ASP A 1 187 ? -24.02523 13.48354 -25.10996 1.000 88.07000  ? 167 ASP A CA  1 
ATOM   1255 C  C   . ASP A 1 187 ? -25.23030 13.83102 -24.23962 1.000 86.77000  ? 167 ASP A C   1 
ATOM   1256 O  O   . ASP A 1 187 ? -25.58365 13.08313 -23.31970 1.000 80.47000  ? 167 ASP A O   1 
ATOM   1257 C  CB  . ASP A 1 187 ? -22.86715 14.43078 -24.82589 1.000 91.84000  ? 167 ASP A CB  1 
ATOM   1258 C  CG  . ASP A 1 187 ? -21.53359 13.85193 -25.20798 1.000 89.99000  ? 167 ASP A CG  1 
ATOM   1259 O  OD1 . ASP A 1 187 ? -21.41578 12.60767 -25.25264 1.000 93.24000  ? 167 ASP A OD1 1 
ATOM   1260 O  OD2 . ASP A 1 187 ? -20.60567 14.64791 -25.46053 1.000 86.01000  ? 167 ASP A OD2 1 
ATOM   1261 N  N   . TYR A 1 188 ? -25.87263 14.96700 -24.51620 1.000 81.92000  ? 168 TYR A N   1 
ATOM   1262 C  CA  . TYR A 1 188 ? -27.05126 15.41010 -23.77502 1.000 81.60000  ? 168 TYR A CA  1 
ATOM   1263 C  C   . TYR A 1 188 ? -28.35532 14.98137 -24.42843 1.000 79.29000  ? 168 TYR A C   1 
ATOM   1264 O  O   . TYR A 1 188 ? -29.32091 15.74819 -24.46002 1.000 76.77000  ? 168 TYR A O   1 
ATOM   1265 C  CB  . TYR A 1 188 ? -27.01067 16.92432 -23.57875 1.000 84.12000  ? 168 TYR A CB  1 
ATOM   1266 C  CG  . TYR A 1 188 ? -26.80810 17.77266 -24.82226 1.000 83.74000  ? 168 TYR A CG  1 
ATOM   1267 C  CD1 . TYR A 1 188 ? -27.86177 18.02296 -25.70583 1.000 86.32000  ? 168 TYR A CD1 1 
ATOM   1268 C  CD2 . TYR A 1 188 ? -25.57528 18.36687 -25.09076 1.000 88.20000  ? 168 TYR A CD2 1 
ATOM   1269 C  CE1 . TYR A 1 188 ? -27.68463 18.81820 -26.83873 1.000 84.59000  ? 168 TYR A CE1 1 
ATOM   1270 C  CE2 . TYR A 1 188 ? -25.38819 19.16312 -26.21999 1.000 91.14000  ? 168 TYR A CE2 1 
ATOM   1271 C  CZ  . TYR A 1 188 ? -26.44863 19.38465 -27.08793 1.000 87.28000  ? 168 TYR A CZ  1 
ATOM   1272 O  OH  . TYR A 1 188 ? -26.26953 20.16685 -28.20624 1.000 93.53000  ? 168 TYR A OH  1 
ATOM   1273 N  N   . ALA A 1 189 ? -28.41995 13.74284 -24.92616 1.000 83.71000  ? 169 ALA A N   1 
ATOM   1274 C  CA  . ALA A 1 189 ? -29.63105 13.26938 -25.59170 1.000 82.45000  ? 169 ALA A CA  1 
ATOM   1275 C  C   . ALA A 1 189 ? -30.76827 13.05618 -24.59964 1.000 76.68000  ? 169 ALA A C   1 
ATOM   1276 O  O   . ALA A 1 189 ? -31.94709 13.18033 -24.97162 1.000 78.01000  ? 169 ALA A O   1 
ATOM   1277 C  CB  . ALA A 1 189 ? -29.34380 11.97763 -26.36163 1.000 77.08000  ? 169 ALA A CB  1 
ATOM   1278 N  N   . TYR A 1 190 ? -30.43553 12.72649 -23.34355 1.000 76.84000  ? 170 TYR A N   1 
ATOM   1279 C  CA  . TYR A 1 190 ? -31.46681 12.61055 -22.31769 1.000 72.53000  ? 170 TYR A CA  1 
ATOM   1280 C  C   . TYR A 1 190 ? -32.26347 13.89953 -22.20275 1.000 71.14000  ? 170 TYR A C   1 
ATOM   1281 O  O   . TYR A 1 190 ? -33.49475 13.87555 -22.10732 1.000 70.59000  ? 170 TYR A O   1 
ATOM   1282 C  CB  . TYR A 1 190 ? -30.84233 12.26037 -20.96551 1.000 78.25000  ? 170 TYR A CB  1 
ATOM   1283 C  CG  . TYR A 1 190 ? -31.87976 12.07599 -19.88166 1.000 76.07000  ? 170 TYR A CG  1 
ATOM   1284 C  CD1 . TYR A 1 190 ? -32.49190 10.84524 -19.69386 1.000 69.81000  ? 170 TYR A CD1 1 
ATOM   1285 C  CD2 . TYR A 1 190 ? -32.27774 13.14351 -19.08214 1.000 72.36000  ? 170 TYR A CD2 1 
ATOM   1286 C  CE1 . TYR A 1 190 ? -33.44794 10.67102 -18.73322 1.000 70.20000  ? 170 TYR A CE1 1 
ATOM   1287 C  CE2 . TYR A 1 190 ? -33.24233 12.98389 -18.12839 1.000 71.18000  ? 170 TYR A CE2 1 
ATOM   1288 C  CZ  . TYR A 1 190 ? -33.82409 11.74341 -17.94819 1.000 74.71000  ? 170 TYR A CZ  1 
ATOM   1289 O  OH  . TYR A 1 190 ? -34.78814 11.56507 -16.98403 1.000 78.46000  ? 170 TYR A OH  1 
ATOM   1290 N  N   . PHE A 1 191 ? -31.57547 15.03541 -22.24027 1.000 69.38000  ? 171 PHE A N   1 
ATOM   1291 C  CA  . PHE A 1 191 ? -32.24837 16.31911 -22.11402 1.000 73.56000  ? 171 PHE A CA  1 
ATOM   1292 C  C   . PHE A 1 191 ? -32.97000 16.71759 -23.38955 1.000 77.19000  ? 171 PHE A C   1 
ATOM   1293 O  O   . PHE A 1 191 ? -34.07276 17.27021 -23.33331 1.000 76.06000  ? 171 PHE A O   1 
ATOM   1294 C  CB  . PHE A 1 191 ? -31.24094 17.38445 -21.72755 1.000 72.46000  ? 171 PHE A CB  1 
ATOM   1295 C  CG  . PHE A 1 191 ? -30.58878 17.12338 -20.41897 1.000 77.65000  ? 171 PHE A CG  1 
ATOM   1296 C  CD1 . PHE A 1 191 ? -31.34856 17.02656 -19.26916 1.000 73.56000  ? 171 PHE A CD1 1 
ATOM   1297 C  CD2 . PHE A 1 191 ? -29.22807 16.98128 -20.33136 1.000 74.35000  ? 171 PHE A CD2 1 
ATOM   1298 C  CE1 . PHE A 1 191 ? -30.76372 16.78780 -18.04433 1.000 76.92000  ? 171 PHE A CE1 1 
ATOM   1299 C  CE2 . PHE A 1 191 ? -28.62772 16.74668 -19.11751 1.000 78.08000  ? 171 PHE A CE2 1 
ATOM   1300 C  CZ  . PHE A 1 191 ? -29.39970 16.65100 -17.96114 1.000 81.85000  ? 171 PHE A CZ  1 
ATOM   1301 N  N   . THR A 1 192 ? -32.36008 16.46779 -24.54580 1.000 76.07000  ? 172 THR A N   1 
ATOM   1302 C  CA  . THR A 1 192 ? -33.05263 16.75004 -25.79928 1.000 70.91000  ? 172 THR A CA  1 
ATOM   1303 C  C   . THR A 1 192 ? -34.33598 15.93565 -25.91583 1.000 68.34000  ? 172 THR A C   1 
ATOM   1304 O  O   . THR A 1 192 ? -35.33576 16.42715 -26.45130 1.000 63.65000  ? 172 THR A O   1 
ATOM   1305 C  CB  . THR A 1 192 ? -32.10457 16.50955 -26.99297 1.000 71.01000  ? 172 THR A CB  1 
ATOM   1306 O  OG1 . THR A 1 192 ? -30.86896 17.21414 -26.78100 1.000 63.09000  ? 172 THR A OG1 1 
ATOM   1307 C  CG2 . THR A 1 192 ? -32.72385 16.92770 -28.31329 1.000 60.96000  ? 172 THR A CG2 1 
ATOM   1308 N  N   . GLU A 1 193 ? -34.34385 14.70653 -25.39632 1.000 71.91000  ? 173 GLU A N   1 
ATOM   1309 C  CA  . GLU A 1 193 ? -35.57866 13.92943 -25.40968 1.000 75.80000  ? 173 GLU A CA  1 
ATOM   1310 C  C   . GLU A 1 193 ? -36.59049 14.51796 -24.43167 1.000 75.63000  ? 173 GLU A C   1 
ATOM   1311 O  O   . GLU A 1 193 ? -37.74853 14.77375 -24.78588 1.000 70.48000  ? 173 GLU A O   1 
ATOM   1312 C  CB  . GLU A 1 193 ? -35.28827 12.46456 -25.07261 1.000 75.97000  ? 173 GLU A CB  1 
ATOM   1313 C  CG  . GLU A 1 193 ? -36.49707 11.52595 -25.21751 1.000 79.75000  ? 173 GLU A CG  1 
ATOM   1314 C  CD  . GLU A 1 193 ? -36.78523 11.13398 -26.67900 1.000 98.69000  ? 173 GLU A CD  1 
ATOM   1315 O  OE1 . GLU A 1 193 ? -35.96722 10.37658 -27.26242 1.000 101.15000 ? 173 GLU A OE1 1 
ATOM   1316 O  OE2 . GLU A 1 193 ? -37.82860 11.56801 -27.23847 1.000 95.78000  ? 173 GLU A OE2 1 
ATOM   1317 N  N   . HIS A 1 194 ? -36.15723 14.77167 -23.19788 1.000 74.94000  ? 174 HIS A N   1 
ATOM   1318 C  CA  . HIS A 1 194 ? -37.09896 15.18546 -22.16795 1.000 79.87000  ? 174 HIS A CA  1 
ATOM   1319 C  C   . HIS A 1 194 ? -37.57206 16.62118 -22.36594 1.000 76.03000  ? 174 HIS A C   1 
ATOM   1320 O  O   . HIS A 1 194 ? -38.66168 16.96546 -21.89469 1.000 71.74000  ? 174 HIS A O   1 
ATOM   1321 C  CB  . HIS A 1 194 ? -36.47528 14.97760 -20.78639 1.000 69.41000  ? 174 HIS A CB  1 
ATOM   1322 C  CG  . HIS A 1 194 ? -36.76418 13.63106 -20.19769 1.000 73.94000  ? 174 HIS A CG  1 
ATOM   1323 N  ND1 . HIS A 1 194 ? -36.06191 12.49762 -20.55201 1.000 75.20000  ? 174 HIS A ND1 1 
ATOM   1324 C  CD2 . HIS A 1 194 ? -37.69119 13.23151 -19.28988 1.000 79.83000  ? 174 HIS A CD2 1 
ATOM   1325 C  CE1 . HIS A 1 194 ? -36.53539 11.46356 -19.87664 1.000 83.17000  ? 174 HIS A CE1 1 
ATOM   1326 N  NE2 . HIS A 1 194 ? -37.52707 11.88012 -19.10506 1.000 69.35000  ? 174 HIS A NE2 1 
ATOM   1327 N  N   . GLU A 1 195 ? -36.80577 17.44250 -23.09405 1.000 73.89000  ? 175 GLU A N   1 
ATOM   1328 C  CA  . GLU A 1 195 ? -37.24677 18.78710 -23.45069 1.000 70.89000  ? 175 GLU A CA  1 
ATOM   1329 C  C   . GLU A 1 195 ? -38.56994 18.78431 -24.20045 1.000 71.79000  ? 175 GLU A C   1 
ATOM   1330 O  O   . GLU A 1 195 ? -39.29287 19.78298 -24.16555 1.000 68.63000  ? 175 GLU A O   1 
ATOM   1331 N  N   . GLU A 1 196 ? -38.91923 17.68624 -24.84847 1.000 72.62000  ? 176 GLU A N   1 
ATOM   1332 C  CA  . GLU A 1 196 ? -40.12680 17.62159 -25.66170 1.000 66.15000  ? 176 GLU A CA  1 
ATOM   1333 C  C   . GLU A 1 196 ? -41.10547 16.55914 -25.19355 1.000 65.29000  ? 176 GLU A C   1 
ATOM   1334 O  O   . GLU A 1 196 ? -42.31471 16.75668 -25.28139 1.000 66.89000  ? 176 GLU A O   1 
ATOM   1335 C  CB  . GLU A 1 196 ? -39.75083 17.35619 -27.14397 1.000 31.63000  ? 176 GLU A CB  1 
ATOM   1336 C  CG  . GLU A 1 196 ? -39.35693 18.61862 -27.92612 1.000 31.63000  ? 176 GLU A CG  1 
ATOM   1337 N  N   . ALA A 1 197 ? -40.61003 15.42156 -24.72023 1.000 64.81000  ? 177 ALA A N   1 
ATOM   1338 C  CA  . ALA A 1 197 ? -41.50480 14.36526 -24.27520 1.000 63.99000  ? 177 ALA A CA  1 
ATOM   1339 C  C   . ALA A 1 197 ? -42.29720 14.78430 -23.03368 1.000 64.39000  ? 177 ALA A C   1 
ATOM   1340 O  O   . ALA A 1 197 ? -43.50238 14.52511 -22.94799 1.000 61.52000  ? 177 ALA A O   1 
ATOM   1341 C  CB  . ALA A 1 197 ? -40.70036 13.09274 -24.00287 1.000 61.61000  ? 177 ALA A CB  1 
ATOM   1342 N  N   . ASP A 1 198 ? -41.64286 15.43078 -22.06411 1.000 58.20000  ? 178 ASP A N   1 
ATOM   1343 C  CA  . ASP A 1 198 ? -42.32673 15.74692 -20.81514 1.000 68.63000  ? 178 ASP A CA  1 
ATOM   1344 C  C   . ASP A 1 198 ? -43.38015 16.83346 -20.98623 1.000 65.44000  ? 178 ASP A C   1 
ATOM   1345 O  O   . ASP A 1 198 ? -44.27046 16.93608 -20.14159 1.000 60.27000  ? 178 ASP A O   1 
ATOM   1346 C  CB  . ASP A 1 198 ? -41.30393 16.09371 -19.71737 1.000 62.56000  ? 178 ASP A CB  1 
ATOM   1347 C  CG  . ASP A 1 198 ? -40.90767 14.85755 -18.90574 1.000 70.40000  ? 178 ASP A CG  1 
ATOM   1348 O  OD1 . ASP A 1 198 ? -41.50548 13.79781 -19.17103 1.000 69.54000  ? 178 ASP A OD1 1 
ATOM   1349 O  OD2 . ASP A 1 198 ? -39.99594 14.89833 -18.05236 1.000 72.48000  ? 178 ASP A OD2 1 
ATOM   1350 N  N   . VAL A 1 199 ? -43.34236 17.60409 -22.07683 1.000 64.52000  ? 179 VAL A N   1 
ATOM   1351 C  CA  . VAL A 1 199 ? -44.48091 18.46140 -22.40353 1.000 58.58000  ? 179 VAL A CA  1 
ATOM   1352 C  C   . VAL A 1 199 ? -45.75309 17.63807 -22.52086 1.000 62.98000  ? 179 VAL A C   1 
ATOM   1353 O  O   . VAL A 1 199 ? -46.81332 18.02660 -22.01953 1.000 65.07000  ? 179 VAL A O   1 
ATOM   1354 C  CB  . VAL A 1 199 ? -44.21098 19.26374 -23.69115 1.000 69.01000  ? 179 VAL A CB  1 
ATOM   1355 C  CG1 . VAL A 1 199 ? -45.45530 20.03391 -24.11960 1.000 65.67000  ? 179 VAL A CG1 1 
ATOM   1356 C  CG2 . VAL A 1 199 ? -43.08007 20.25622 -23.44757 1.000 67.04000  ? 179 VAL A CG2 1 
ATOM   1357 N  N   . ARG A 1 200 ? -45.67249 16.49376 -23.19047 1.000 64.90000  ? 180 ARG A N   1 
ATOM   1358 C  CA  . ARG A 1 200 ? -46.84975 15.65248 -23.34711 1.000 62.10000  ? 180 ARG A CA  1 
ATOM   1359 C  C   . ARG A 1 200 ? -47.20420 14.95214 -22.03820 1.000 61.10000  ? 180 ARG A C   1 
ATOM   1360 O  O   . ARG A 1 200 ? -48.38377 14.79143 -21.71078 1.000 64.18000  ? 180 ARG A O   1 
ATOM   1361 C  CB  . ARG A 1 200 ? -46.60333 14.65090 -24.47652 1.000 60.20000  ? 180 ARG A CB  1 
ATOM   1362 C  CG  . ARG A 1 200 ? -47.65601 13.56368 -24.64335 1.000 66.61000  ? 180 ARG A CG  1 
ATOM   1363 C  CD  . ARG A 1 200 ? -47.22916 12.54992 -25.73480 1.000 72.83000  ? 180 ARG A CD  1 
ATOM   1364 N  NE  . ARG A 1 200 ? -45.91565 11.96173 -25.47175 1.000 74.61000  ? 180 ARG A NE  1 
ATOM   1365 C  CZ  . ARG A 1 200 ? -44.86136 12.08733 -26.27129 1.000 78.89000  ? 180 ARG A CZ  1 
ATOM   1366 N  NH1 . ARG A 1 200 ? -44.93617 12.75799 -27.41439 1.000 86.64000  ? 180 ARG A NH1 1 
ATOM   1367 N  NH2 . ARG A 1 200 ? -43.69986 11.54177 -25.90679 1.000 70.37000  ? 180 ARG A NH2 1 
ATOM   1368 N  N   . HIS A 1 201 ? -46.19826 14.55305 -21.26262 1.000 61.96000  ? 181 HIS A N   1 
ATOM   1369 C  CA  . HIS A 1 201 ? -46.45909 13.79113 -20.04618 1.000 64.96000  ? 181 HIS A CA  1 
ATOM   1370 C  C   . HIS A 1 201 ? -47.18754 14.63816 -19.00973 1.000 57.30000  ? 181 HIS A C   1 
ATOM   1371 O  O   . HIS A 1 201 ? -48.21625 14.21708 -18.46806 1.000 57.90000  ? 181 HIS A O   1 
ATOM   1372 C  CB  . HIS A 1 201 ? -45.15274 13.25923 -19.48597 1.000 63.34000  ? 181 HIS A CB  1 
ATOM   1373 C  CG  . HIS A 1 201 ? -44.52264 12.21320 -20.33598 1.000 64.31000  ? 181 HIS A CG  1 
ATOM   1374 N  ND1 . HIS A 1 201 ? -43.17072 11.94574 -20.30508 1.000 65.18000  ? 181 HIS A ND1 1 
ATOM   1375 C  CD2 . HIS A 1 201 ? -45.06025 11.35703 -21.23509 1.000 59.82000  ? 181 HIS A CD2 1 
ATOM   1376 C  CE1 . HIS A 1 201 ? -42.90395 10.97121 -21.15511 1.000 75.83000  ? 181 HIS A CE1 1 
ATOM   1377 N  NE2 . HIS A 1 201 ? -44.03308 10.59769 -21.73191 1.000 59.38000  ? 181 HIS A NE2 1 
ATOM   1378 N  N   . ALA A 1 202 ? -46.67073 15.84281 -18.74077 1.000 59.09000  ? 182 ALA A N   1 
ATOM   1379 C  CA  . ALA A 1 202 ? -47.38688 16.82180 -17.93037 1.000 58.00000  ? 182 ALA A CA  1 
ATOM   1380 C  C   . ALA A 1 202 ? -48.84247 16.94845 -18.35617 1.000 62.65000  ? 182 ALA A C   1 
ATOM   1381 O  O   . ALA A 1 202 ? -49.75579 16.83366 -17.52703 1.000 58.64000  ? 182 ALA A O   1 
ATOM   1382 C  CB  . ALA A 1 202 ? -46.69803 18.18009 -18.03181 1.000 52.67000  ? 182 ALA A CB  1 
ATOM   1383 N  N   . ARG A 1 203 ? -49.07887 17.15502 -19.66356 1.000 57.66000  ? 183 ARG A N   1 
ATOM   1384 C  CA  . ARG A 1 203 ? -50.43184 17.43412 -20.12428 1.000 56.35000  ? 183 ARG A CA  1 
ATOM   1385 C  C   . ARG A 1 203 ? -51.34403 16.24323 -19.90383 1.000 56.83000  ? 183 ARG A C   1 
ATOM   1386 O  O   . ARG A 1 203 ? -52.49150 16.41317 -19.48040 1.000 61.22000  ? 183 ARG A O   1 
ATOM   1387 C  CB  . ARG A 1 203 ? -50.43373 17.85962 -21.60377 1.000 54.78000  ? 183 ARG A CB  1 
ATOM   1388 C  CG  . ARG A 1 203 ? -51.82781 17.79079 -22.26835 1.000 51.45000  ? 183 ARG A CG  1 
ATOM   1389 C  CD  . ARG A 1 203 ? -51.82270 18.29387 -23.75275 1.000 69.32000  ? 183 ARG A CD  1 
ATOM   1390 N  NE  . ARG A 1 203 ? -51.18741 17.36343 -24.68161 1.000 51.06000  ? 183 ARG A NE  1 
ATOM   1391 C  CZ  . ARG A 1 203 ? -51.72932 16.22127 -25.07814 1.000 58.74000  ? 183 ARG A CZ  1 
ATOM   1392 N  NH1 . ARG A 1 203 ? -52.96817 15.89468 -24.75775 1.000 58.89000  ? 183 ARG A NH1 1 
ATOM   1393 N  NH2 . ARG A 1 203 ? -51.00489 15.37497 -25.79753 1.000 69.27000  ? 183 ARG A NH2 1 
ATOM   1394 N  N   . GLU A 1 204 ? -50.86574 15.03194 -20.17946 1.000 61.46000  ? 184 GLU A N   1 
ATOM   1395 C  CA  . GLU A 1 204 ? -51.73697 13.87483 -19.99451 1.000 63.09000  ? 184 GLU A CA  1 
ATOM   1396 C  C   . GLU A 1 204 ? -51.87270 13.51530 -18.52530 1.000 56.26000  ? 184 GLU A C   1 
ATOM   1397 O  O   . GLU A 1 204 ? -52.88228 12.92800 -18.12062 1.000 56.39000  ? 184 GLU A O   1 
ATOM   1398 C  CB  . GLU A 1 204 ? -51.22053 12.67922 -20.79890 1.000 59.28000  ? 184 GLU A CB  1 
ATOM   1399 C  CG  . GLU A 1 204 ? -50.82145 13.05314 -22.22198 1.000 67.91000  ? 184 GLU A CG  1 
ATOM   1400 C  CD  . GLU A 1 204 ? -50.90589 11.89761 -23.20788 1.000 76.68000  ? 184 GLU A CD  1 
ATOM   1401 O  OE1 . GLU A 1 204 ? -50.22545 10.86806 -22.96967 1.000 74.24000  ? 184 GLU A OE1 1 
ATOM   1402 O  OE2 . GLU A 1 204 ? -51.62798 12.04277 -24.22949 1.000 85.81000  ? 184 GLU A OE2 1 
ATOM   1403 N  N   . GLU A 1 205 ? -50.86851 13.86125 -17.72516 1.000 52.47000  ? 185 GLU A N   1 
ATOM   1404 C  CA  . GLU A 1 205 ? -50.97391 13.67855 -16.28697 1.000 60.20000  ? 185 GLU A CA  1 
ATOM   1405 C  C   . GLU A 1 205 ? -52.04869 14.58703 -15.70183 1.000 63.51000  ? 185 GLU A C   1 
ATOM   1406 O  O   . GLU A 1 205 ? -52.84315 14.14935 -14.86176 1.000 58.30000  ? 185 GLU A O   1 
ATOM   1407 C  CB  . GLU A 1 205 ? -49.61056 13.92469 -15.63622 1.000 52.89000  ? 185 GLU A CB  1 
ATOM   1408 C  CG  . GLU A 1 205 ? -48.90689 12.63573 -15.26244 1.000 55.61000  ? 185 GLU A CG  1 
ATOM   1409 C  CD  . GLU A 1 205 ? -47.38711 12.69745 -15.35297 1.000 56.14000  ? 185 GLU A CD  1 
ATOM   1410 O  OE1 . GLU A 1 205 ? -46.78424 13.78593 -15.26862 1.000 58.42000  ? 185 GLU A OE1 1 
ATOM   1411 O  OE2 . GLU A 1 205 ? -46.77500 11.62561 -15.46157 1.000 54.98000  ? 185 GLU A OE2 1 
ATOM   1412 N  N   . LYS A 1 206 ? -52.09645 15.84862 -16.15001 1.000 59.83000  ? 186 LYS A N   1 
ATOM   1413 C  CA  . LYS A 1 206 ? -53.10429 16.77335 -15.65266 1.000 58.30000  ? 186 LYS A CA  1 
ATOM   1414 C  C   . LYS A 1 206 ? -54.49826 16.29798 -16.00725 1.000 65.15000  ? 186 LYS A C   1 
ATOM   1415 O  O   . LYS A 1 206 ? -55.44655 16.50633 -15.24274 1.000 61.63000  ? 186 LYS A O   1 
ATOM   1416 C  CB  . LYS A 1 206 ? -52.85772 18.16724 -16.21775 1.000 68.55000  ? 186 LYS A CB  1 
ATOM   1417 C  CG  . LYS A 1 206 ? -53.67836 19.25454 -15.54764 1.000 71.15000  ? 186 LYS A CG  1 
ATOM   1418 C  CD  . LYS A 1 206 ? -52.84377 20.47212 -15.23202 1.000 70.20000  ? 186 LYS A CD  1 
ATOM   1419 C  CE  . LYS A 1 206 ? -53.26392 21.61789 -16.12285 1.000 66.46000  ? 186 LYS A CE  1 
ATOM   1420 N  NZ  . LYS A 1 206 ? -52.78249 22.92249 -15.61237 1.000 68.71000  ? 186 LYS A NZ  1 
ATOM   1421 N  N   . ALA A 1 207 ? -54.62859 15.64305 -17.15094 1.000 53.48000  ? 187 ALA A N   1 
ATOM   1422 C  CA  . ALA A 1 207 ? -55.87767 14.99993 -17.52084 1.000 59.37000  ? 187 ALA A CA  1 
ATOM   1423 C  C   . ALA A 1 207 ? -56.14530 13.78336 -16.64363 1.000 57.67000  ? 187 ALA A C   1 
ATOM   1424 O  O   . ALA A 1 207 ? -57.29103 13.51284 -16.28227 1.000 60.57000  ? 187 ALA A O   1 
ATOM   1425 C  CB  . ALA A 1 207 ? -55.82628 14.60820 -19.00857 1.000 56.14000  ? 187 ALA A CB  1 
ATOM   1426 N  N   . LEU A 1 208 ? -55.10116 13.02221 -16.31988 1.000 56.86000  ? 188 LEU A N   1 
ATOM   1427 C  CA  . LEU A 1 208 ? -55.25770 11.86658 -15.43846 1.000 62.68000  ? 188 LEU A CA  1 
ATOM   1428 C  C   . LEU A 1 208 ? -55.77105 12.28545 -14.06181 1.000 58.66000  ? 188 LEU A C   1 
ATOM   1429 O  O   . LEU A 1 208 ? -56.68347 11.66439 -13.50714 1.000 60.63000  ? 188 LEU A O   1 
ATOM   1430 C  CB  . LEU A 1 208 ? -53.92359 11.14400 -15.29240 1.000 55.64000  ? 188 LEU A CB  1 
ATOM   1431 C  CG  . LEU A 1 208 ? -53.52588 10.19646 -16.41228 1.000 61.03000  ? 188 LEU A CG  1 
ATOM   1432 C  CD1 . LEU A 1 208 ? -52.09588 9.66153  -16.17352 1.000 56.60000  ? 188 LEU A CD1 1 
ATOM   1433 C  CD2 . LEU A 1 208 ? -54.54713 9.07477  -16.56909 1.000 51.52000  ? 188 LEU A CD2 1 
ATOM   1434 N  N   . ILE A 1 209 ? -55.17496 13.33481 -13.49657 1.000 53.23000  ? 189 ILE A N   1 
ATOM   1435 C  CA  . ILE A 1 209 ? -55.62239 13.87125 -12.21493 1.000 61.23000  ? 189 ILE A CA  1 
ATOM   1436 C  C   . ILE A 1 209 ? -57.12155 14.12720 -12.24229 1.000 64.80000  ? 189 ILE A C   1 
ATOM   1437 O  O   . ILE A 1 209 ? -57.85735 13.73926 -11.32958 1.000 64.38000  ? 189 ILE A O   1 
ATOM   1438 C  CB  . ILE A 1 209 ? -54.84349 15.15422 -11.87664 1.000 59.15000  ? 189 ILE A CB  1 
ATOM   1439 C  CG1 . ILE A 1 209 ? -53.35100 14.84435 -11.76385 1.000 52.61000  ? 189 ILE A CG1 1 
ATOM   1440 C  CG2 . ILE A 1 209 ? -55.39284 15.78768 -10.59003 1.000 58.81000  ? 189 ILE A CG2 1 
ATOM   1441 C  CD1 . ILE A 1 209 ? -52.48571 16.03123 -11.54366 1.000 54.84000  ? 189 ILE A CD1 1 
ATOM   1442 N  N   . GLU A 1 210 ? -57.59809 14.76507 -13.30458 1.000 65.85000  ? 190 GLU A N   1 
ATOM   1443 C  CA  . GLU A 1 210 ? -59.01241 15.09145 -13.38955 1.000 67.18000  ? 190 GLU A CA  1 
ATOM   1444 C  C   . GLU A 1 210 ? -59.85878 13.83210 -13.53465 1.000 66.10000  ? 190 GLU A C   1 
ATOM   1445 O  O   . GLU A 1 210 ? -60.84620 13.66501 -12.81192 1.000 71.58000  ? 190 GLU A O   1 
ATOM   1446 C  CB  . GLU A 1 210 ? -59.24905 16.06607 -14.54158 1.000 62.96000  ? 190 GLU A CB  1 
ATOM   1447 C  CG  . GLU A 1 210 ? -60.59549 16.77424 -14.48247 1.000 78.20000  ? 190 GLU A CG  1 
ATOM   1448 C  CD  . GLU A 1 210 ? -60.48918 18.29607 -14.62330 1.000 91.63000  ? 190 GLU A CD  1 
ATOM   1449 O  OE1 . GLU A 1 210 ? -59.75474 18.76108 -15.53138 1.000 85.30000  ? 190 GLU A OE1 1 
ATOM   1450 O  OE2 . GLU A 1 210 ? -61.14109 19.02013 -13.81805 1.000 87.76000  ? 190 GLU A OE2 1 
ATOM   1451 N  N   . MET A 1 211 ? -59.48051 12.91678 -14.44704 1.000 58.72000  ? 191 MET A N   1 
ATOM   1452 C  CA  . MET A 1 211 ? -60.24255 11.67107 -14.60381 1.000 56.94000  ? 191 MET A CA  1 
ATOM   1453 C  C   . MET A 1 211 ? -60.26551 10.81884 -13.34298 1.000 58.98000  ? 191 MET A C   1 
ATOM   1454 O  O   . MET A 1 211 ? -61.22880 10.07841 -13.11515 1.000 49.94000  ? 191 MET A O   1 
ATOM   1455 C  CB  . MET A 1 211 ? -59.70035 10.76848 -15.71956 1.000 64.46000  ? 191 MET A CB  1 
ATOM   1456 C  CG  . MET A 1 211 ? -59.24823 11.34854 -17.04038 1.000 70.34000  ? 191 MET A CG  1 
ATOM   1457 S  SD  . MET A 1 211 ? -58.20899 10.09197 -17.85616 1.000 70.39000  ? 191 MET A SD  1 
ATOM   1458 C  CE  . MET A 1 211 ? -59.40143 8.83779  -18.27863 1.000 55.13000  ? 191 MET A CE  1 
ATOM   1459 N  N   . LEU A 1 212 ? -59.18849 10.81199 -12.57635 1.000 58.84000  ? 192 LEU A N   1 
ATOM   1460 C  CA  . LEU A 1 212 ? -59.09053 9.84932  -11.48755 1.000 63.69000  ? 192 LEU A CA  1 
ATOM   1461 C  C   . LEU A 1 212 ? -59.57761 10.40780 -10.15250 1.000 65.59000  ? 192 LEU A C   1 
ATOM   1462 O  O   . LEU A 1 212 ? -59.65430 9.65248  -9.17563  1.000 63.92000  ? 192 LEU A O   1 
ATOM   1463 C  CB  . LEU A 1 212 ? -57.64806 9.33865  -11.36753 1.000 50.24000  ? 192 LEU A CB  1 
ATOM   1464 C  CG  . LEU A 1 212 ? -57.11097 8.54253  -12.56205 1.000 54.23000  ? 192 LEU A CG  1 
ATOM   1465 C  CD1 . LEU A 1 212 ? -55.62126 8.46096  -12.50224 1.000 47.97000  ? 192 LEU A CD1 1 
ATOM   1466 C  CD2 . LEU A 1 212 ? -57.69541 7.16505  -12.63958 1.000 57.88000  ? 192 LEU A CD2 1 
ATOM   1467 N  N   . LEU A 1 213 ? -59.93075 11.69631 -10.10766 1.000 66.63000  ? 193 LEU A N   1 
ATOM   1468 C  CA  . LEU A 1 213 ? -60.26593 12.36706 -8.85724  1.000 65.63000  ? 193 LEU A CA  1 
ATOM   1469 C  C   . LEU A 1 213 ? -61.46083 11.72196 -8.18188  1.000 60.00000  ? 193 LEU A C   1 
ATOM   1470 O  O   . LEU A 1 213 ? -62.45340 11.37603 -8.82362  1.000 64.75000  ? 193 LEU A O   1 
ATOM   1471 C  CB  . LEU A 1 213 ? -60.57947 13.82769 -9.12002  1.000 64.78000  ? 193 LEU A CB  1 
ATOM   1472 C  CG  . LEU A 1 213 ? -60.62026 14.68940 -7.87950  1.000 66.99000  ? 193 LEU A CG  1 
ATOM   1473 C  CD1 . LEU A 1 213 ? -59.24660 15.26768 -7.63113  1.000 65.99000  ? 193 LEU A CD1 1 
ATOM   1474 C  CD2 . LEU A 1 213 ? -61.62160 15.77360 -8.07581  1.000 62.10000  ? 193 LEU A CD2 1 
ATOM   1475 N  N   . LYS A 1 214 ? -61.35948 11.56097 -6.87750  1.000 61.85000  ? 194 LYS A N   1 
ATOM   1476 C  CA  . LYS A 1 214 ? -62.44719 11.02626 -6.09770  1.000 67.75000  ? 194 LYS A CA  1 
ATOM   1477 C  C   . LYS A 1 214 ? -62.34299 11.70737 -4.73114  1.000 72.69000  ? 194 LYS A C   1 
ATOM   1478 O  O   . LYS A 1 214 ? -61.90511 11.13213 -3.73976  1.000 76.44000  ? 194 LYS A O   1 
ATOM   1479 C  CB  . LYS A 1 214 ? -62.39403 9.49701  -6.01723  1.000 31.63000  ? 194 LYS A CB  1 
ATOM   1480 C  CG  . LYS A 1 214 ? -62.97516 8.73415  -7.29798  1.000 31.63000  ? 194 LYS A CG  1 
ATOM   1481 N  N   . ASP A 1 215 ? -62.71583 12.98835 -4.71702  1.000 68.19000  ? 195 ASP A N   1 
ATOM   1482 C  CA  . ASP A 1 215 ? -62.75916 13.82203 -3.51288  1.000 73.63000  ? 195 ASP A CA  1 
ATOM   1483 C  C   . ASP A 1 215 ? -61.43975 13.86204 -2.75261  1.000 72.99000  ? 195 ASP A C   1 
ATOM   1484 O  O   . ASP A 1 215 ? -61.42721 14.05790 -1.53851  1.000 82.27000  ? 195 ASP A O   1 
ATOM   1485 C  CB  . ASP A 1 215 ? -63.86832 13.39073 -2.55094  0.538 31.63000  ? 195 ASP A CB  1 
ATOM   1486 C  CG  . ASP A 1 215 ? -65.13637 14.15496 -2.77158  0.213 31.63000  ? 195 ASP A CG  1 
ATOM   1487 O  OD1 . ASP A 1 215 ? -65.19744 15.33742 -2.35957  0.493 31.63000  ? 195 ASP A OD1 1 
ATOM   1488 O  OD2 . ASP A 1 215 ? -66.07671 13.55715 -3.33929  0.369 31.63000  ? 195 ASP A OD2 1 
ATOM   1489 N  N   . ASP A 1 216 ? -60.31788 13.71593 -3.43692  1.000 68.29000  ? 196 ASP A N   1 
ATOM   1490 C  CA  . ASP A 1 216 ? -59.01548 13.78574 -2.79466  1.000 68.41000  ? 196 ASP A CA  1 
ATOM   1491 C  C   . ASP A 1 216 ? -58.21908 15.01114 -3.22585  1.000 67.67000  ? 196 ASP A C   1 
ATOM   1492 O  O   . ASP A 1 216 ? -56.98360 14.98960 -3.21309  1.000 62.78000  ? 196 ASP A O   1 
ATOM   1493 C  CB  . ASP A 1 216 ? -58.21378 12.52754 -3.08718  1.000 68.79000  ? 196 ASP A CB  1 
ATOM   1494 C  CG  . ASP A 1 216 ? -58.67993 11.83909 -4.31274  1.000 67.79000  ? 196 ASP A CG  1 
ATOM   1495 O  OD1 . ASP A 1 216 ? -59.10252 12.53180 -5.27141  1.000 68.67000  ? 196 ASP A OD1 1 
ATOM   1496 O  OD2 . ASP A 1 216 ? -58.62547 10.59921 -4.29944  1.000 62.85000  ? 196 ASP A OD2 1 
ATOM   1497 N  N   . ALA A 1 217 ? -58.90775 16.08823 -3.60671  1.000 67.04000  ? 197 ALA A N   1 
ATOM   1498 C  CA  . ALA A 1 217 ? -58.19689 17.28290 -4.05350  1.000 62.47000  ? 197 ALA A CA  1 
ATOM   1499 C  C   . ALA A 1 217 ? -57.17178 17.73515 -3.03135  1.000 63.16000  ? 197 ALA A C   1 
ATOM   1500 O  O   . ALA A 1 217 ? -56.13000 18.29512 -3.38895  1.000 59.88000  ? 197 ALA A O   1 
ATOM   1501 C  CB  . ALA A 1 217 ? -59.18291 18.40672 -4.33696  1.000 63.60000  ? 197 ALA A CB  1 
ATOM   1502 N  N   . ASP A 1 218 ? -57.45072 17.49599 -1.75679  1.000 65.99000  ? 198 ASP A N   1 
ATOM   1503 C  CA  . ASP A 1 218 ? -56.51728 17.88506 -0.71658  1.000 63.43000  ? 198 ASP A CA  1 
ATOM   1504 C  C   . ASP A 1 218 ? -55.25822 17.03765 -0.78649  1.000 56.27000  ? 198 ASP A C   1 
ATOM   1505 O  O   . ASP A 1 218 ? -54.14805 17.54565 -0.56194  1.000 54.45000  ? 198 ASP A O   1 
ATOM   1506 C  CB  . ASP A 1 218 ? -57.20494 17.75719 0.64237   1.000 69.85000  ? 198 ASP A CB  1 
ATOM   1507 C  CG  . ASP A 1 218 ? -58.09943 16.52208 0.71761   1.000 78.84000  ? 198 ASP A CG  1 
ATOM   1508 O  OD1 . ASP A 1 218 ? -58.84083 16.27368 -0.27129  1.000 82.62000  ? 198 ASP A OD1 1 
ATOM   1509 O  OD2 . ASP A 1 218 ? -58.04875 15.79625 1.73965   1.000 85.82000  ? 198 ASP A OD2 1 
ATOM   1510 N  N   . LYS A 1 219 ? -55.42015 15.74029 -1.08520  1.000 57.92000  ? 199 LYS A N   1 
ATOM   1511 C  CA  . LYS A 1 219 ? -54.27079 14.85422 -1.23854  1.000 60.59000  ? 199 LYS A CA  1 
ATOM   1512 C  C   . LYS A 1 219 ? -53.38143 15.31081 -2.39142  1.000 60.37000  ? 199 LYS A C   1 
ATOM   1513 O  O   . LYS A 1 219 ? -52.15540 15.42523 -2.23924  1.000 58.80000  ? 199 LYS A O   1 
ATOM   1514 C  CB  . LYS A 1 219 ? -54.74974 13.42301 -1.46206  1.000 62.94000  ? 199 LYS A CB  1 
ATOM   1515 C  CG  . LYS A 1 219 ? -55.83655 12.97563 -0.50733  1.000 64.04000  ? 199 LYS A CG  1 
ATOM   1516 C  CD  . LYS A 1 219 ? -55.28786 12.00164 0.55360   1.000 65.21000  ? 199 LYS A CD  1 
ATOM   1517 N  N   . VAL A 1 220 ? -54.00446 15.57998 -3.55350  1.000 60.25000  ? 200 VAL A N   1 
ATOM   1518 C  CA  . VAL A 1 220 ? -53.31596 16.11931 -4.72842  1.000 57.19000  ? 200 VAL A CA  1 
ATOM   1519 C  C   . VAL A 1 220 ? -52.44782 17.30477 -4.32633  1.000 62.87000  ? 200 VAL A C   1 
ATOM   1520 O  O   . VAL A 1 220 ? -51.24664 17.35580 -4.62657  1.000 57.30000  ? 200 VAL A O   1 
ATOM   1521 C  CB  . VAL A 1 220 ? -54.35266 16.51366 -5.80606  1.000 57.11000  ? 200 VAL A CB  1 
ATOM   1522 C  CG1 . VAL A 1 220 ? -53.81014 17.55281 -6.77116  1.000 48.85000  ? 200 VAL A CG1 1 
ATOM   1523 C  CG2 . VAL A 1 220 ? -54.92622 15.29232 -6.52911  1.000 51.08000  ? 200 VAL A CG2 1 
ATOM   1524 N  N   . LEU A 1 221 ? -53.04543 18.26570 -3.60948  1.000 64.72000  ? 201 LEU A N   1 
ATOM   1525 C  CA  . LEU A 1 221 ? -52.29561 19.44244 -3.17955  1.000 61.32000  ? 201 LEU A CA  1 
ATOM   1526 C  C   . LEU A 1 221 ? -51.18968 19.07038 -2.20390  1.000 58.69000  ? 201 LEU A C   1 
ATOM   1527 O  O   . LEU A 1 221 ? -50.15371 19.73248 -2.15583  1.000 60.80000  ? 201 LEU A O   1 
ATOM   1528 C  CB  . LEU A 1 221 ? -53.24253 20.47269 -2.54919  1.000 59.20000  ? 201 LEU A CB  1 
ATOM   1529 C  CG  . LEU A 1 221 ? -54.34600 21.12876 -3.39270  1.000 68.10000  ? 201 LEU A CG  1 
ATOM   1530 C  CD1 . LEU A 1 221 ? -53.83674 21.52244 -4.80036  1.000 57.08000  ? 201 LEU A CD1 1 
ATOM   1531 N  N   . GLU A 1 222 ? -51.38178 18.01685 -1.42278  1.000 66.01000  ? 202 GLU A N   1 
ATOM   1532 C  CA  . GLU A 1 222 ? -50.38031 17.70885 -0.40861  1.000 65.07000  ? 202 GLU A CA  1 
ATOM   1533 C  C   . GLU A 1 222 ? -49.21326 16.95320 -1.01547  1.000 57.14000  ? 202 GLU A C   1 
ATOM   1534 O  O   . GLU A 1 222 ? -48.05692 17.22111 -0.67051  1.000 58.39000  ? 202 GLU A O   1 
ATOM   1535 C  CB  . GLU A 1 222 ? -51.00993 16.91646 0.74010   1.000 63.96000  ? 202 GLU A CB  1 
ATOM   1536 C  CG  . GLU A 1 222 ? -50.09306 16.73323 1.91978   1.000 69.10000  ? 202 GLU A CG  1 
ATOM   1537 C  CD  . GLU A 1 222 ? -50.60445 15.69950 2.91568   1.000 81.15000  ? 202 GLU A CD  1 
ATOM   1538 O  OE1 . GLU A 1 222 ? -51.71375 15.15058 2.69056   1.000 75.33000  ? 202 GLU A OE1 1 
ATOM   1539 O  OE2 . GLU A 1 222 ? -49.88721 15.43286 3.91562   1.000 73.04000  ? 202 GLU A OE2 1 
ATOM   1540 N  N   . ALA A 1 223 ? -49.51479 16.01489 -1.92584  1.000 61.77000  ? 203 ALA A N   1 
ATOM   1541 C  CA  . ALA A 1 223 ? -48.47789 15.33391 -2.69669  1.000 60.06000  ? 203 ALA A CA  1 
ATOM   1542 C  C   . ALA A 1 223 ? -47.56584 16.34176 -3.36584  1.000 60.64000  ? 203 ALA A C   1 
ATOM   1543 O  O   . ALA A 1 223 ? -46.33667 16.20892 -3.34045  1.000 61.58000  ? 203 ALA A O   1 
ATOM   1544 C  CB  . ALA A 1 223 ? -49.12596 14.42005 -3.73218  1.000 60.66000  ? 203 ALA A CB  1 
ATOM   1545 N  N   . SER A 1 224 ? -48.15882 17.39394 -3.91463  1.000 59.51000  ? 204 SER A N   1 
ATOM   1546 C  CA  . SER A 1 224 ? -47.38498 18.40915 -4.60510  1.000 59.37000  ? 204 SER A CA  1 
ATOM   1547 C  C   . SER A 1 224 ? -46.47605 19.16156 -3.64239  1.000 57.12000  ? 204 SER A C   1 
ATOM   1548 O  O   . SER A 1 224 ? -45.28813 19.35672 -3.91515  1.000 63.37000  ? 204 SER A O   1 
ATOM   1549 C  CB  . SER A 1 224 ? -48.33652 19.36202 -5.31478  1.000 54.62000  ? 204 SER A CB  1 
ATOM   1550 O  OG  . SER A 1 224 ? -47.60918 20.17070 -6.20157  1.000 64.21000  ? 204 SER A OG  1 
ATOM   1551 N  N   . GLN A 1 225 ? -47.02488 19.61386 -2.51567  1.000 64.46000  ? 205 GLN A N   1 
ATOM   1552 C  CA  . GLN A 1 225 ? -46.19700 20.26346 -1.49850  1.000 64.61000  ? 205 GLN A CA  1 
ATOM   1553 C  C   . GLN A 1 225 ? -45.02354 19.37622 -1.09055  1.000 62.42000  ? 205 GLN A C   1 
ATOM   1554 O  O   . GLN A 1 225 ? -43.88595 19.84369 -0.99877  1.000 57.50000  ? 205 GLN A O   1 
ATOM   1555 C  CB  . GLN A 1 225 ? -47.04630 20.62549 -0.27121  1.000 64.09000  ? 205 GLN A CB  1 
ATOM   1556 C  CG  . GLN A 1 225 ? -48.21155 21.56808 -0.56627  1.000 71.99000  ? 205 GLN A CG  1 
ATOM   1557 C  CD  . GLN A 1 225 ? -48.85694 22.19646 0.67241   1.000 82.38000  ? 205 GLN A CD  1 
ATOM   1558 O  OE1 . GLN A 1 225 ? -48.81584 21.63555 1.77316   1.000 81.03000  ? 205 GLN A OE1 1 
ATOM   1559 N  NE2 . GLN A 1 225 ? -49.49405 23.35440 0.47984   1.000 83.52000  ? 205 GLN A NE2 1 
ATOM   1560 N  N   . GLU A 1 226 ? -45.28088 18.09027 -0.84675  1.000 56.75000  ? 206 GLU A N   1 
ATOM   1561 C  CA  . GLU A 1 226 ? -44.21676 17.21595 -0.38071  1.000 59.20000  ? 206 GLU A CA  1 
ATOM   1562 C  C   . GLU A 1 226 ? -43.17686 16.98891 -1.45654  1.000 66.74000  ? 206 GLU A C   1 
ATOM   1563 O  O   . GLU A 1 226 ? -41.97412 17.03923 -1.17462  1.000 64.04000  ? 206 GLU A O   1 
ATOM   1564 C  CB  . GLU A 1 226 ? -44.78617 15.88037 0.05669   1.000 67.66000  ? 206 GLU A CB  1 
ATOM   1565 C  CG  . GLU A 1 226 ? -45.20706 15.84439 1.49948   1.000 76.36000  ? 206 GLU A CG  1 
ATOM   1566 C  CD  . GLU A 1 226 ? -45.71594 14.48273 1.90637   1.000 76.07000  ? 206 GLU A CD  1 
ATOM   1567 O  OE1 . GLU A 1 226 ? -45.25495 13.47874 1.30690   1.000 76.78000  ? 206 GLU A OE1 1 
ATOM   1568 O  OE2 . GLU A 1 226 ? -46.57474 14.43070 2.82424   1.000 72.27000  ? 206 GLU A OE2 1 
ATOM   1569 N  N   . VAL A 1 227 ? -43.62168 16.73674 -2.70006  1.000 60.79000  ? 207 VAL A N   1 
ATOM   1570 C  CA  . VAL A 1 227 ? -42.68778 16.34906 -3.74515  1.000 54.02000  ? 207 VAL A CA  1 
ATOM   1571 C  C   . VAL A 1 227 ? -41.75527 17.50041 -4.06682  1.000 62.69000  ? 207 VAL A C   1 
ATOM   1572 O  O   . VAL A 1 227 ? -40.53731 17.32092 -4.16630  1.000 66.39000  ? 207 VAL A O   1 
ATOM   1573 C  CB  . VAL A 1 227 ? -43.45398 15.84856 -4.98038  1.000 62.64000  ? 207 VAL A CB  1 
ATOM   1574 C  CG1 . VAL A 1 227 ? -42.64450 16.09252 -6.29101  1.000 61.18000  ? 207 VAL A CG1 1 
ATOM   1575 C  CG2 . VAL A 1 227 ? -43.80767 14.37020 -4.80570  1.000 57.77000  ? 207 VAL A CG2 1 
ATOM   1576 N  N   . THR A 1 228 ? -42.30085 18.70793 -4.16959  1.000 65.29000  ? 208 THR A N   1 
ATOM   1577 C  CA  . THR A 1 228 ? -41.48467 19.87306 -4.50225  1.000 68.06000  ? 208 THR A CA  1 
ATOM   1578 C  C   . THR A 1 228 ? -40.44138 20.17055 -3.42221  1.000 66.96000  ? 208 THR A C   1 
ATOM   1579 O  O   . THR A 1 228 ? -39.30433 20.54476 -3.73713  1.000 61.24000  ? 208 THR A O   1 
ATOM   1580 C  CB  . THR A 1 228 ? -42.39961 21.07269 -4.72762  1.000 75.35000  ? 208 THR A CB  1 
ATOM   1581 O  OG1 . THR A 1 228 ? -43.50384 21.00420 -3.80608  1.000 66.42000  ? 208 THR A OG1 1 
ATOM   1582 C  CG2 . THR A 1 228 ? -42.93470 21.05884 -6.12583  1.000 53.93000  ? 208 THR A CG2 1 
ATOM   1583 N  N   . GLN A 1 229 ? -40.80803 20.01084 -2.14311  1.000 69.65000  ? 209 GLN A N   1 
ATOM   1584 C  CA  . GLN A 1 229 ? -39.83610 20.17836 -1.05975  1.000 67.84000  ? 209 GLN A CA  1 
ATOM   1585 C  C   . GLN A 1 229 ? -38.80273 19.05690 -1.05846  1.000 64.70000  ? 209 GLN A C   1 
ATOM   1586 O  O   . GLN A 1 229 ? -37.61694 19.30047 -0.80573  1.000 60.38000  ? 209 GLN A O   1 
ATOM   1587 C  CB  . GLN A 1 229 ? -40.53830 20.21606 0.29540   1.000 69.80000  ? 209 GLN A CB  1 
ATOM   1588 C  CG  . GLN A 1 229 ? -41.47936 21.38590 0.53435   1.000 79.47000  ? 209 GLN A CG  1 
ATOM   1589 C  CD  . GLN A 1 229 ? -41.97974 21.41712 1.97070   1.000 74.75000  ? 209 GLN A CD  1 
ATOM   1590 O  OE1 . GLN A 1 229 ? -41.18823 21.59467 2.90731   1.000 79.61000  ? 209 GLN A OE1 1 
ATOM   1591 N  NE2 . GLN A 1 229 ? -43.28935 21.19772 2.15841   1.000 69.29000  ? 209 GLN A NE2 1 
ATOM   1592 N  N   . SER A 1 230 ? -39.23783 17.81661 -1.31821  1.000 68.41000  ? 210 SER A N   1 
ATOM   1593 C  CA  . SER A 1 230 ? -38.29122 16.70920 -1.40835  1.000 73.52000  ? 210 SER A CA  1 
ATOM   1594 C  C   . SER A 1 230 ? -37.33084 16.90375 -2.57906  1.000 74.78000  ? 210 SER A C   1 
ATOM   1595 O  O   . SER A 1 230 ? -36.15237 16.55017 -2.48063  1.000 77.75000  ? 210 SER A O   1 
ATOM   1596 C  CB  . SER A 1 230 ? -39.04272 15.37741 -1.51270  1.000 58.94000  ? 210 SER A CB  1 
ATOM   1597 N  N   . LEU A 1 231 ? -37.79532 17.50942 -3.67115  1.000 60.41000  ? 211 LEU A N   1 
ATOM   1598 C  CA  . LEU A 1 231 ? -36.88415 17.79965 -4.77438  1.000 67.52000  ? 211 LEU A CA  1 
ATOM   1599 C  C   . LEU A 1 231 ? -35.92588 18.91755 -4.40214  1.000 73.63000  ? 211 LEU A C   1 
ATOM   1600 O  O   . LEU A 1 231 ? -34.73872 18.86213 -4.74223  1.000 73.38000  ? 211 LEU A O   1 
ATOM   1601 C  CB  . LEU A 1 231 ? -37.65445 18.16358 -6.04529  1.000 61.03000  ? 211 LEU A CB  1 
ATOM   1602 C  CG  . LEU A 1 231 ? -38.34218 17.01793 -6.80110  1.000 70.46000  ? 211 LEU A CG  1 
ATOM   1603 C  CD1 . LEU A 1 231 ? -39.20022 17.53743 -7.96637  1.000 66.40000  ? 211 LEU A CD1 1 
ATOM   1604 C  CD2 . LEU A 1 231 ? -37.34207 15.95467 -7.28637  1.000 65.62000  ? 211 LEU A CD2 1 
ATOM   1605 N  N   . TYR A 1 232 ? -36.41903 19.94309 -3.70211  1.000 71.77000  ? 212 TYR A N   1 
ATOM   1606 C  CA  . TYR A 1 232 ? -35.53290 21.02021 -3.27765  1.000 74.71000  ? 212 TYR A CA  1 
ATOM   1607 C  C   . TYR A 1 232 ? -34.47977 20.50167 -2.31870  1.000 71.40000  ? 212 TYR A C   1 
ATOM   1608 O  O   . TYR A 1 232 ? -33.31616 20.91169 -2.38534  1.000 72.65000  ? 212 TYR A O   1 
ATOM   1609 C  CB  . TYR A 1 232 ? -36.33437 22.14544 -2.63719  1.000 74.02000  ? 212 TYR A CB  1 
ATOM   1610 C  CG  . TYR A 1 232 ? -36.43796 23.39549 -3.48575  1.000 69.19000  ? 212 TYR A CG  1 
ATOM   1611 C  CD1 . TYR A 1 232 ? -37.17538 23.40106 -4.66366  1.000 65.25000  ? 212 TYR A CD1 1 
ATOM   1612 C  CD2 . TYR A 1 232 ? -35.83414 24.57559 -3.08918  1.000 65.82000  ? 212 TYR A CD2 1 
ATOM   1613 C  CE1 . TYR A 1 232 ? -37.28794 24.54879 -5.43051  1.000 70.23000  ? 212 TYR A CE1 1 
ATOM   1614 C  CE2 . TYR A 1 232 ? -35.93964 25.72450 -3.85285  1.000 70.86000  ? 212 TYR A CE2 1 
ATOM   1615 C  CZ  . TYR A 1 232 ? -36.66734 25.70709 -5.02009  1.000 71.21000  ? 212 TYR A CZ  1 
ATOM   1616 O  OH  . TYR A 1 232 ? -36.78302 26.84870 -5.77065  1.000 70.73000  ? 212 TYR A OH  1 
ATOM   1617 N  N   . GLY A 1 233 ? -34.86475 19.57666 -1.43486  1.000 71.28000  ? 213 GLY A N   1 
ATOM   1618 C  CA  . GLY A 1 233 ? -33.90067 18.99079 -0.51792  1.000 71.41000  ? 213 GLY A CA  1 
ATOM   1619 C  C   . GLY A 1 233 ? -32.80889 18.21308 -1.22336  1.000 73.03000  ? 213 GLY A C   1 
ATOM   1620 O  O   . GLY A 1 233 ? -31.65575 18.20341 -0.77411  1.000 67.90000  ? 213 GLY A O   1 
ATOM   1621 N  N   . PHE A 1 234 ? -33.14884 17.56584 -2.34504  1.000 75.04000  ? 214 PHE A N   1 
ATOM   1622 C  CA  . PHE A 1 234 ? -32.14869 16.81523 -3.09418  1.000 69.64000  ? 214 PHE A CA  1 
ATOM   1623 C  C   . PHE A 1 234 ? -31.11332 17.74994 -3.70048  1.000 71.21000  ? 214 PHE A C   1 
ATOM   1624 O  O   . PHE A 1 234 ? -29.90910 17.49592 -3.62366  1.000 76.70000  ? 214 PHE A O   1 
ATOM   1625 C  CB  . PHE A 1 234 ? -32.81958 15.96445 -4.16898  1.000 75.29000  ? 214 PHE A CB  1 
ATOM   1626 C  CG  . PHE A 1 234 ? -31.84540 15.23169 -5.04266  1.000 73.95000  ? 214 PHE A CG  1 
ATOM   1627 C  CD1 . PHE A 1 234 ? -31.25964 14.05362 -4.61507  1.000 74.41000  ? 214 PHE A CD1 1 
ATOM   1628 C  CD2 . PHE A 1 234 ? -31.50234 15.72541 -6.28324  1.000 73.33000  ? 214 PHE A CD2 1 
ATOM   1629 C  CE1 . PHE A 1 234 ? -30.34969 13.38512 -5.40157  1.000 73.96000  ? 214 PHE A CE1 1 
ATOM   1630 C  CE2 . PHE A 1 234 ? -30.59202 15.05559 -7.07188  1.000 78.47000  ? 214 PHE A CE2 1 
ATOM   1631 C  CZ  . PHE A 1 234 ? -30.01427 13.88411 -6.62386  1.000 76.38000  ? 214 PHE A CZ  1 
ATOM   1632 N  N   . LEU A 1 235 ? -31.56066 18.86167 -4.26918  1.000 71.01000  ? 215 LEU A N   1 
ATOM   1633 C  CA  . LEU A 1 235 ? -30.62933 19.80651 -4.86544  1.000 74.70000  ? 215 LEU A CA  1 
ATOM   1634 C  C   . LEU A 1 235 ? -29.72620 20.45550 -3.81957  1.000 77.53000  ? 215 LEU A C   1 
ATOM   1635 O  O   . LEU A 1 235 ? -28.65127 20.95730 -4.16876  1.000 79.02000  ? 215 LEU A O   1 
ATOM   1636 C  CB  . LEU A 1 235 ? -31.42050 20.85042 -5.66578  1.000 72.90000  ? 215 LEU A CB  1 
ATOM   1637 C  CG  . LEU A 1 235 ? -31.70138 20.52312 -7.13813  1.000 72.90000  ? 215 LEU A CG  1 
ATOM   1638 C  CD1 . LEU A 1 235 ? -32.07572 19.06482 -7.34623  1.000 77.31000  ? 215 LEU A CD1 1 
ATOM   1639 C  CD2 . LEU A 1 235 ? -32.80193 21.41435 -7.72298  1.000 79.07000  ? 215 LEU A CD2 1 
ATOM   1640 N  N   . ASP A 1 236 ? -30.12185 20.43291 -2.53839  1.000 80.69000  ? 216 ASP A N   1 
ATOM   1641 C  CA  . ASP A 1 236 ? -29.32078 21.07366 -1.49212  1.000 83.04000  ? 216 ASP A CA  1 
ATOM   1642 C  C   . ASP A 1 236 ? -28.06692 20.28078 -1.14289  1.000 83.35000  ? 216 ASP A C   1 
ATOM   1643 O  O   . ASP A 1 236 ? -27.07658 20.87253 -0.70269  1.000 86.81000  ? 216 ASP A O   1 
ATOM   1644 C  CB  . ASP A 1 236 ? -30.13150 21.26785 -0.20229  1.000 73.14000  ? 216 ASP A CB  1 
ATOM   1645 C  CG  . ASP A 1 236 ? -31.40769 22.07829 -0.40226  1.000 76.05000  ? 216 ASP A CG  1 
ATOM   1646 O  OD1 . ASP A 1 236 ? -31.45254 22.91209 -1.33873  1.000 80.82000  ? 216 ASP A OD1 1 
ATOM   1647 O  OD2 . ASP A 1 236 ? -32.37048 21.87217 0.38472   1.000 73.40000  ? 216 ASP A OD2 1 
ATOM   1648 N  N   . SER A 1 237 ? -28.08656 18.95738 -1.31102  1.000 75.44000  ? 217 SER A N   1 
ATOM   1649 C  CA  . SER A 1 237 ? -26.96512 18.13714 -0.87144  1.000 82.07000  ? 217 SER A CA  1 
ATOM   1650 C  C   . SER A 1 237 ? -25.68065 18.35396 -1.67197  1.000 85.93000  ? 217 SER A C   1 
ATOM   1651 O  O   . SER A 1 237 ? -24.65468 17.76738 -1.30648  1.000 85.30000  ? 217 SER A O   1 
ATOM   1652 C  CB  . SER A 1 237 ? -27.35004 16.66133 -0.91250  1.000 82.84000  ? 217 SER A CB  1 
ATOM   1653 O  OG  . SER A 1 237 ? -28.23480 16.39683 -1.98181  1.000 82.82000  ? 217 SER A OG  1 
ATOM   1654 N  N   . PHE A 1 238 ? -25.68750 19.17436 -2.72758  1.000 81.57000  ? 218 PHE A N   1 
ATOM   1655 C  CA  . PHE A 1 238 ? -24.46957 19.48184 -3.47562  1.000 86.88000  ? 218 PHE A CA  1 
ATOM   1656 C  C   . PHE A 1 238 ? -24.08579 20.95734 -3.38704  1.000 91.48000  ? 218 PHE A C   1 
ATOM   1657 O  O   . PHE A 1 238 ? -23.63459 21.55299 -4.36983  1.000 88.44000  ? 218 PHE A O   1 
ATOM   1658 C  CB  . PHE A 1 238 ? -24.59131 19.07747 -4.94313  1.000 83.38000  ? 218 PHE A CB  1 
ATOM   1659 C  CG  . PHE A 1 238 ? -25.46954 17.88680 -5.18579  1.000 85.48000  ? 218 PHE A CG  1 
ATOM   1660 C  CD1 . PHE A 1 238 ? -24.93756 16.60972 -5.18948  1.000 81.72000  ? 218 PHE A CD1 1 
ATOM   1661 C  CD2 . PHE A 1 238 ? -26.82183 18.04225 -5.44851  1.000 81.28000  ? 218 PHE A CD2 1 
ATOM   1662 C  CE1 . PHE A 1 238 ? -25.74637 15.49755 -5.42404  1.000 83.03000  ? 218 PHE A CE1 1 
ATOM   1663 C  CE2 . PHE A 1 238 ? -27.63456 16.93922 -5.69118  1.000 81.56000  ? 218 PHE A CE2 1 
ATOM   1664 C  CZ  . PHE A 1 238 ? -27.09430 15.66322 -5.67611  1.000 83.16000  ? 218 PHE A CZ  1 
ATOM   1665 N  N   . LEU A 1 239 ? -24.23163 21.55851 -2.20851  1.000 90.17000  ? 219 LEU A N   1 
ATOM   1666 C  CA  . LEU A 1 239 ? -23.92489 22.97447 -2.03984  1.000 90.19000  ? 219 LEU A CA  1 
ATOM   1667 C  C   . LEU A 1 239 ? -23.63944 23.29496 -0.57500  1.000 89.64000  ? 219 LEU A C   1 
ATOM   1668 C  CB  . LEU A 1 239 ? -25.08276 23.83795 -2.56931  1.000 84.91000  ? 219 LEU A CB  1 
ATOM   1669 C  CG  . LEU A 1 239 ? -25.07222 24.28335 -4.03622  1.000 87.03000  ? 219 LEU A CG  1 
ATOM   1670 N  N   . MET B 1 26  ? -45.57357 15.75816 -32.20128 1.000 85.73000  ? 6   MET B N   1 
ATOM   1671 C  CA  . MET B 1 26  ? -46.56896 14.92898 -31.53087 1.000 90.61000  ? 6   MET B CA  1 
ATOM   1672 C  C   . MET B 1 26  ? -47.97409 15.54583 -31.59688 1.000 88.02000  ? 6   MET B C   1 
ATOM   1673 O  O   . MET B 1 26  ? -48.46375 15.85782 -32.68531 1.000 83.18000  ? 6   MET B O   1 
ATOM   1674 N  N   . ASN B 1 27  ? -48.61870 15.70933 -30.43420 1.000 86.70000  ? 7   ASN B N   1 
ATOM   1675 C  CA  . ASN B 1 27  ? -49.94070 16.33045 -30.36193 1.000 72.94000  ? 7   ASN B CA  1 
ATOM   1676 C  C   . ASN B 1 27  ? -49.81733 17.85116 -30.44440 1.000 62.50000  ? 7   ASN B C   1 
ATOM   1677 O  O   . ASN B 1 27  ? -48.81892 18.44639 -30.02142 1.000 65.08000  ? 7   ASN B O   1 
ATOM   1678 C  CB  . ASN B 1 27  ? -50.67156 15.90436 -29.07758 1.000 71.37000  ? 7   ASN B CB  1 
ATOM   1679 C  CG  . ASN B 1 27  ? -52.09538 16.45078 -28.98740 1.000 64.71000  ? 7   ASN B CG  1 
ATOM   1680 O  OD1 . ASN B 1 27  ? -52.30004 17.65494 -28.88872 1.000 67.04000  ? 7   ASN B OD1 1 
ATOM   1681 N  ND2 . ASN B 1 27  ? -53.07584 15.56616 -28.99567 1.000 66.17000  ? 7   ASN B ND2 1 
ATOM   1682 N  N   . PHE B 1 28  ? -50.85033 18.47651 -31.00841 1.000 65.67000  ? 8   PHE B N   1 
ATOM   1683 C  CA  . PHE B 1 28  ? -50.72884 19.86249 -31.44641 1.000 67.42000  ? 8   PHE B CA  1 
ATOM   1684 C  C   . PHE B 1 28  ? -50.75578 20.85498 -30.28985 1.000 66.61000  ? 8   PHE B C   1 
ATOM   1685 O  O   . PHE B 1 28  ? -50.08938 21.89410 -30.37268 1.000 67.50000  ? 8   PHE B O   1 
ATOM   1686 C  CB  . PHE B 1 28  ? -51.81452 20.18728 -32.47945 1.000 68.38000  ? 8   PHE B CB  1 
ATOM   1687 C  CG  . PHE B 1 28  ? -53.14684 20.53727 -31.89568 1.000 68.16000  ? 8   PHE B CG  1 
ATOM   1688 C  CD1 . PHE B 1 28  ? -54.08270 19.56180 -31.65118 1.000 64.50000  ? 8   PHE B CD1 1 
ATOM   1689 C  CD2 . PHE B 1 28  ? -53.47592 21.85160 -31.62392 1.000 63.25000  ? 8   PHE B CD2 1 
ATOM   1690 C  CE1 . PHE B 1 28  ? -55.31895 19.89236 -31.12200 1.000 64.68000  ? 8   PHE B CE1 1 
ATOM   1691 C  CE2 . PHE B 1 28  ? -54.70348 22.18137 -31.09975 1.000 55.48000  ? 8   PHE B CE2 1 
ATOM   1692 C  CZ  . PHE B 1 28  ? -55.62128 21.20702 -30.84397 1.000 58.68000  ? 8   PHE B CZ  1 
ATOM   1693 N  N   . LEU B 1 29  ? -51.51038 20.55999 -29.22124 1.000 61.21000  ? 9   LEU B N   1 
ATOM   1694 C  CA  . LEU B 1 29  ? -51.38396 21.33536 -27.99275 1.000 64.28000  ? 9   LEU B CA  1 
ATOM   1695 C  C   . LEU B 1 29  ? -49.95341 21.29449 -27.47952 1.000 64.25000  ? 9   LEU B C   1 
ATOM   1696 O  O   . LEU B 1 29  ? -49.39697 22.32233 -27.06720 1.000 65.58000  ? 9   LEU B O   1 
ATOM   1697 C  CB  . LEU B 1 29  ? -52.35194 20.80910 -26.93295 1.000 60.00000  ? 9   LEU B CB  1 
ATOM   1698 C  CG  . LEU B 1 29  ? -53.79902 20.71115 -27.41355 1.000 59.56000  ? 9   LEU B CG  1 
ATOM   1699 C  CD1 . LEU B 1 29  ? -54.59848 19.76352 -26.53491 1.000 66.19000  ? 9   LEU B CD1 1 
ATOM   1700 C  CD2 . LEU B 1 29  ? -54.46283 22.08236 -27.49327 1.000 58.85000  ? 9   LEU B CD2 1 
ATOM   1701 N  N   . ASP B 1 30  ? -49.33030 20.12072 -27.52317 1.000 58.33000  ? 10  ASP B N   1 
ATOM   1702 C  CA  . ASP B 1 30  ? -47.93501 20.06041 -27.13297 1.000 53.68000  ? 10  ASP B CA  1 
ATOM   1703 C  C   . ASP B 1 30  ? -47.06622 20.84834 -28.09741 1.000 65.06000  ? 10  ASP B C   1 
ATOM   1704 O  O   . ASP B 1 30  ? -46.08391 21.46745 -27.68266 1.000 65.73000  ? 10  ASP B O   1 
ATOM   1705 C  CB  . ASP B 1 30  ? -47.47780 18.61202 -27.02797 1.000 55.46000  ? 10  ASP B CB  1 
ATOM   1706 C  CG  . ASP B 1 30  ? -48.40341 17.77972 -26.16815 1.000 68.29000  ? 10  ASP B CG  1 
ATOM   1707 O  OD1 . ASP B 1 30  ? -48.89511 18.27865 -25.11353 1.000 69.03000  ? 10  ASP B OD1 1 
ATOM   1708 O  OD2 . ASP B 1 30  ? -48.66078 16.62634 -26.56048 1.000 73.05000  ? 10  ASP B OD2 1 
ATOM   1709 N  N   . GLN B 1 31  ? -47.40161 20.86051 -29.38601 1.000 60.50000  ? 11  GLN B N   1 
ATOM   1710 C  CA  . GLN B 1 31  ? -46.60890 21.71599 -30.25774 1.000 67.77000  ? 11  GLN B CA  1 
ATOM   1711 C  C   . GLN B 1 31  ? -46.87829 23.17839 -29.93397 1.000 65.91000  ? 11  GLN B C   1 
ATOM   1712 O  O   . GLN B 1 31  ? -45.94166 23.98344 -29.84154 1.000 65.57000  ? 11  GLN B O   1 
ATOM   1713 C  CB  . GLN B 1 31  ? -46.87553 21.39848 -31.73444 1.000 62.91000  ? 11  GLN B CB  1 
ATOM   1714 N  N   . LEU B 1 32  ? -48.14700 23.52231 -29.69898 1.000 59.63000  ? 12  LEU B N   1 
ATOM   1715 C  CA  . LEU B 1 32  ? -48.50353 24.88144 -29.29268 1.000 64.00000  ? 12  LEU B CA  1 
ATOM   1716 C  C   . LEU B 1 32  ? -47.66614 25.35308 -28.10382 1.000 65.86000  ? 12  LEU B C   1 
ATOM   1717 O  O   . LEU B 1 32  ? -47.06904 26.43667 -28.14342 1.000 67.66000  ? 12  LEU B O   1 
ATOM   1718 C  CB  . LEU B 1 32  ? -50.00127 24.94820 -28.97976 1.000 64.77000  ? 12  LEU B CB  1 
ATOM   1719 C  CG  . LEU B 1 32  ? -50.55281 26.23806 -28.37817 1.000 61.78000  ? 12  LEU B CG  1 
ATOM   1720 C  CD1 . LEU B 1 32  ? -50.48876 27.41657 -29.33533 1.000 64.83000  ? 12  LEU B CD1 1 
ATOM   1721 C  CD2 . LEU B 1 32  ? -51.98102 26.01227 -27.93665 1.000 59.88000  ? 12  LEU B CD2 1 
ATOM   1722 N  N   . ASP B 1 33  ? -47.58390 24.53579 -27.04679 1.000 64.16000  ? 13  ASP B N   1 
ATOM   1723 C  CA  . ASP B 1 33  ? -46.76978 24.91421 -25.89235 1.000 65.89000  ? 13  ASP B CA  1 
ATOM   1724 C  C   . ASP B 1 33  ? -45.30075 25.08239 -26.26651 1.000 66.60000  ? 13  ASP B C   1 
ATOM   1725 O  O   . ASP B 1 33  ? -44.59511 25.88778 -25.65081 1.000 69.45000  ? 13  ASP B O   1 
ATOM   1726 C  CB  . ASP B 1 33  ? -46.93450 23.87988 -24.76961 1.000 63.54000  ? 13  ASP B CB  1 
ATOM   1727 C  CG  . ASP B 1 33  ? -48.23796 24.06080 -23.98811 1.000 71.54000  ? 13  ASP B CG  1 
ATOM   1728 O  OD1 . ASP B 1 33  ? -48.71220 25.20891 -23.86657 1.000 73.91000  ? 13  ASP B OD1 1 
ATOM   1729 O  OD2 . ASP B 1 33  ? -48.80016 23.05290 -23.50399 1.000 66.69000  ? 13  ASP B OD2 1 
ATOM   1730 N  N   . LEU B 1 34  ? -44.82586 24.35745 -27.28925 1.000 73.36000  ? 14  LEU B N   1 
ATOM   1731 C  CA  . LEU B 1 34  ? -43.40587 24.40785 -27.64694 1.000 72.45000  ? 14  LEU B CA  1 
ATOM   1732 C  C   . LEU B 1 34  ? -43.02288 25.69284 -28.37582 1.000 70.96000  ? 14  LEU B C   1 
ATOM   1733 O  O   . LEU B 1 34  ? -41.96628 26.27169 -28.08383 1.000 67.16000  ? 14  LEU B O   1 
ATOM   1734 C  CB  . LEU B 1 34  ? -43.01699 23.18704 -28.47940 1.000 64.32000  ? 14  LEU B CB  1 
ATOM   1735 C  CG  . LEU B 1 34  ? -42.80053 21.93845 -27.62481 1.000 69.33000  ? 14  LEU B CG  1 
ATOM   1736 C  CD1 . LEU B 1 34  ? -42.57831 20.71752 -28.49266 1.000 70.60000  ? 14  LEU B CD1 1 
ATOM   1737 C  CD2 . LEU B 1 34  ? -41.64506 22.14898 -26.60633 1.000 60.11000  ? 14  LEU B CD2 1 
ATOM   1738 N  N   . ILE B 1 35  ? -43.85220 26.14473 -29.32254 1.000 67.26000  ? 15  ILE B N   1 
ATOM   1739 C  CA  . ILE B 1 35  ? -43.64371 27.46172 -29.92550 1.000 73.09000  ? 15  ILE B CA  1 
ATOM   1740 C  C   . ILE B 1 35  ? -43.52532 28.52459 -28.83772 1.000 79.91000  ? 15  ILE B C   1 
ATOM   1741 O  O   . ILE B 1 35  ? -42.68553 29.43332 -28.91102 1.000 80.81000  ? 15  ILE B O   1 
ATOM   1742 C  CB  . ILE B 1 35  ? -44.78370 27.78906 -30.91007 1.000 76.73000  ? 15  ILE B CB  1 
ATOM   1743 C  CG1 . ILE B 1 35  ? -44.83116 26.76640 -32.04211 1.000 65.93000  ? 15  ILE B CG1 1 
ATOM   1744 C  CG2 . ILE B 1 35  ? -44.64988 29.21025 -31.45040 1.000 69.52000  ? 15  ILE B CG2 1 
ATOM   1745 C  CD1 . ILE B 1 35  ? -46.13140 26.77136 -32.82393 1.000 66.37000  ? 15  ILE B CD1 1 
ATOM   1746 N  N   . ILE B 1 36  ? -44.34728 28.40218 -27.79297 1.000 73.51000  ? 16  ILE B N   1 
ATOM   1747 C  CA  . ILE B 1 36  ? -44.37760 29.40022 -26.73300 1.000 70.14000  ? 16  ILE B CA  1 
ATOM   1748 C  C   . ILE B 1 36  ? -43.10146 29.31644 -25.90605 1.000 77.94000  ? 16  ILE B C   1 
ATOM   1749 O  O   . ILE B 1 36  ? -42.51454 30.33932 -25.52179 1.000 74.11000  ? 16  ILE B O   1 
ATOM   1750 C  CB  . ILE B 1 36  ? -45.63808 29.18223 -25.87273 1.000 72.71000  ? 16  ILE B CB  1 
ATOM   1751 C  CG1 . ILE B 1 36  ? -46.88871 29.64289 -26.62526 1.000 73.20000  ? 16  ILE B CG1 1 
ATOM   1752 C  CG2 . ILE B 1 36  ? -45.50441 29.91379 -24.53499 1.000 64.53000  ? 16  ILE B CG2 1 
ATOM   1753 C  CD1 . ILE B 1 36  ? -48.16453 29.50579 -25.85276 1.000 62.37000  ? 16  ILE B CD1 1 
ATOM   1754 N  N   . GLN B 1 37  ? -42.65433 28.09000 -25.62504 1.000 77.59000  ? 17  GLN B N   1 
ATOM   1755 C  CA  . GLN B 1 37  ? -41.46180 27.88634 -24.81643 1.000 78.04000  ? 17  GLN B CA  1 
ATOM   1756 C  C   . GLN B 1 37  ? -40.24898 28.57991 -25.42574 1.000 83.52000  ? 17  GLN B C   1 
ATOM   1757 O  O   . GLN B 1 37  ? -39.43119 29.16188 -24.70547 1.000 86.54000  ? 17  GLN B O   1 
ATOM   1758 C  CB  . GLN B 1 37  ? -41.20714 26.38829 -24.65628 0.915 37.17000  ? 17  GLN B CB  1 
ATOM   1759 C  CG  . GLN B 1 37  ? -40.25354 26.07352 -23.52890 0.584 37.17000  ? 17  GLN B CG  1 
ATOM   1760 C  CD  . GLN B 1 37  ? -40.41801 24.66746 -23.03864 0.344 37.17000  ? 17  GLN B CD  1 
ATOM   1761 O  OE1 . GLN B 1 37  ? -39.84072 23.73865 -23.60508 0.523 37.17000  ? 17  GLN B OE1 1 
ATOM   1762 N  NE2 . GLN B 1 37  ? -41.22725 24.48954 -21.99817 0.484 37.17000  ? 17  GLN B NE2 1 
ATOM   1763 N  N   . ASN B 1 38  ? -40.12986 28.56565 -26.75223 1.000 81.56000  ? 18  ASN B N   1 
ATOM   1764 C  CA  . ASN B 1 38  ? -38.92618 29.10922 -27.36581 1.000 88.29000  ? 18  ASN B CA  1 
ATOM   1765 C  C   . ASN B 1 38  ? -39.04640 30.56980 -27.79344 1.000 86.46000  ? 18  ASN B C   1 
ATOM   1766 O  O   . ASN B 1 38  ? -38.02830 31.27059 -27.84616 1.000 90.14000  ? 18  ASN B O   1 
ATOM   1767 C  CB  . ASN B 1 38  ? -38.50382 28.22388 -28.54196 1.000 87.34000  ? 18  ASN B CB  1 
ATOM   1768 C  CG  . ASN B 1 38  ? -37.96416 26.86710 -28.07211 1.000 91.80000  ? 18  ASN B CG  1 
ATOM   1769 O  OD1 . ASN B 1 38  ? -36.95167 26.79841 -27.35894 1.000 88.43000  ? 18  ASN B OD1 1 
ATOM   1770 N  ND2 . ASN B 1 38  ? -38.65149 25.79127 -28.44374 1.000 94.02000  ? 18  ASN B ND2 1 
ATOM   1771 N  N   . LYS B 1 39  ? -40.24736 31.06666 -28.05711 1.000 78.00000  ? 19  LYS B N   1 
ATOM   1772 C  CA  . LYS B 1 39  ? -40.44946 32.51010 -28.20781 1.000 77.70000  ? 19  LYS B CA  1 
ATOM   1773 C  C   . LYS B 1 39  ? -41.12825 33.11469 -26.97224 1.000 73.50000  ? 19  LYS B C   1 
ATOM   1774 O  O   . LYS B 1 39  ? -42.15610 33.78898 -27.06770 1.000 64.76000  ? 19  LYS B O   1 
ATOM   1775 C  CB  . LYS B 1 39  ? -41.24546 32.79934 -29.48115 0.566 31.63000  ? 19  LYS B CB  1 
ATOM   1776 C  CG  . LYS B 1 39  ? -40.94168 34.18187 -30.10475 0.642 31.63000  ? 19  LYS B CG  1 
ATOM   1777 C  CD  . LYS B 1 39  ? -40.40486 34.04966 -31.55650 0.778 31.63000  ? 19  LYS B CD  1 
ATOM   1778 N  N   . HIS B 1 40  ? -40.55242 32.88811 -25.79009 1.000 80.24000  ? 20  HIS B N   1 
ATOM   1779 C  CA  . HIS B 1 40  ? -41.15313 33.31934 -24.52682 1.000 78.94000  ? 20  HIS B CA  1 
ATOM   1780 C  C   . HIS B 1 40  ? -40.58661 34.66307 -24.08157 1.000 79.94000  ? 20  HIS B C   1 
ATOM   1781 O  O   . HIS B 1 40  ? -39.37229 34.87138 -24.09378 1.000 82.67000  ? 20  HIS B O   1 
ATOM   1782 C  CB  . HIS B 1 40  ? -40.91546 32.26914 -23.44189 1.000 78.22000  ? 20  HIS B CB  1 
ATOM   1783 C  CG  . HIS B 1 40  ? -41.62091 32.54143 -22.13963 1.000 86.98000  ? 20  HIS B CG  1 
ATOM   1784 N  ND1 . HIS B 1 40  ? -41.36466 33.65173 -21.36220 1.000 86.51000  ? 20  HIS B ND1 1 
ATOM   1785 C  CD2 . HIS B 1 40  ? -42.52977 31.80844 -21.44939 1.000 80.90000  ? 20  HIS B CD2 1 
ATOM   1786 C  CE1 . HIS B 1 40  ? -42.10517 33.60740 -20.26851 1.000 84.89000  ? 20  HIS B CE1 1 
ATOM   1787 N  NE2 . HIS B 1 40  ? -42.81867 32.49664 -20.29562 1.000 85.36000  ? 20  HIS B NE2 1 
ATOM   1788 N  N   . MET B 1 41  ? -41.48212 35.55922 -23.65332 1.000 84.16000  ? 21  MET B N   1 
ATOM   1789 C  CA  . MET B 1 41  ? -41.09734 36.93660 -23.33749 1.000 87.60000  ? 21  MET B CA  1 
ATOM   1790 C  C   . MET B 1 41  ? -39.98184 37.01354 -22.30567 1.000 84.32000  ? 21  MET B C   1 
ATOM   1791 O  O   . MET B 1 41  ? -39.14092 37.91505 -22.35828 1.000 86.34000  ? 21  MET B O   1 
ATOM   1792 C  CB  . MET B 1 41  ? -42.30058 37.71528 -22.82386 1.000 77.65000  ? 21  MET B CB  1 
ATOM   1793 C  CG  . MET B 1 41  ? -43.54492 37.53265 -23.62394 1.000 74.03000  ? 21  MET B CG  1 
ATOM   1794 S  SD  . MET B 1 41  ? -44.65245 38.92532 -23.38434 1.000 72.52000  ? 21  MET B SD  1 
ATOM   1795 C  CE  . MET B 1 41  ? -43.46559 40.27351 -23.35338 1.000 75.91000  ? 21  MET B CE  1 
ATOM   1796 N  N   . LEU B 1 42  ? -39.97639 36.11095 -21.33584 1.000 85.56000  ? 22  LEU B N   1 
ATOM   1797 C  CA  . LEU B 1 42  ? -39.06878 36.27445 -20.21086 1.000 85.10000  ? 22  LEU B CA  1 
ATOM   1798 C  C   . LEU B 1 42  ? -37.61438 36.09281 -20.61850 1.000 91.38000  ? 22  LEU B C   1 
ATOM   1799 O  O   . LEU B 1 42  ? -36.71209 36.32809 -19.79929 1.000 84.59000  ? 22  LEU B O   1 
ATOM   1800 C  CB  . LEU B 1 42  ? -39.46804 35.30000 -19.09821 1.000 31.63000  ? 22  LEU B CB  1 
ATOM   1801 C  CG  . LEU B 1 42  ? -40.19811 35.95901 -17.90131 1.000 31.63000  ? 22  LEU B CG  1 
ATOM   1802 N  N   . GLU B 1 43  ? -37.38276 35.70507 -21.87366 1.000 86.33000  ? 23  GLU B N   1 
ATOM   1803 C  CA  . GLU B 1 43  ? -36.05999 35.54746 -22.45276 1.000 87.03000  ? 23  GLU B CA  1 
ATOM   1804 C  C   . GLU B 1 43  ? -35.62734 36.73777 -23.30222 1.000 88.02000  ? 23  GLU B C   1 
ATOM   1805 O  O   . GLU B 1 43  ? -34.44455 36.83884 -23.63747 1.000 94.64000  ? 23  GLU B O   1 
ATOM   1806 C  CB  . GLU B 1 43  ? -36.02483 34.27226 -23.29314 1.000 86.35000  ? 23  GLU B CB  1 
ATOM   1807 C  CG  . GLU B 1 43  ? -35.74170 33.05676 -22.46505 1.000 83.43000  ? 23  GLU B CG  1 
ATOM   1808 C  CD  . GLU B 1 43  ? -35.75393 31.77300 -23.26141 1.000 99.51000  ? 23  GLU B CD  1 
ATOM   1809 O  OE1 . GLU B 1 43  ? -35.99446 31.80153 -24.49282 1.000 105.40000 ? 23  GLU B OE1 1 
ATOM   1810 O  OE2 . GLU B 1 43  ? -35.50754 30.72025 -22.63827 1.000 97.68000  ? 23  GLU B OE2 1 
ATOM   1811 N  N   . HIS B 1 44  ? -36.54595 37.63109 -23.65899 1.000 86.08000  ? 24  HIS B N   1 
ATOM   1812 C  CA  . HIS B 1 44  ? -36.18504 38.86302 -24.34454 1.000 90.86000  ? 24  HIS B CA  1 
ATOM   1813 C  C   . HIS B 1 44  ? -35.17692 39.65512 -23.51779 1.000 93.08000  ? 24  HIS B C   1 
ATOM   1814 O  O   . HIS B 1 44  ? -35.05206 39.48412 -22.29870 1.000 98.88000  ? 24  HIS B O   1 
ATOM   1815 C  CB  . HIS B 1 44  ? -37.42919 39.71214 -24.59708 1.000 85.33000  ? 24  HIS B CB  1 
ATOM   1816 C  CG  . HIS B 1 44  ? -37.37732 40.51465 -25.85608 1.000 87.71000  ? 24  HIS B CG  1 
ATOM   1817 N  ND1 . HIS B 1 44  ? -36.96923 41.83078 -25.88139 1.000 91.03000  ? 24  HIS B ND1 1 
ATOM   1818 C  CD2 . HIS B 1 44  ? -37.69729 40.19382 -27.13576 1.000 88.79000  ? 24  HIS B CD2 1 
ATOM   1819 C  CE1 . HIS B 1 44  ? -37.03976 42.28515 -27.12204 1.000 94.37000  ? 24  HIS B CE1 1 
ATOM   1820 N  NE2 . HIS B 1 44  ? -37.47301 41.31092 -27.90414 1.000 91.35000  ? 24  HIS B NE2 1 
ATOM   1821 N  N   . THR B 1 45  ? -34.44838 40.53883 -24.19902 1.000 95.93000  ? 25  THR B N   1 
ATOM   1822 C  CA  . THR B 1 45  ? -33.43587 41.32504 -23.50479 1.000 90.42000  ? 25  THR B CA  1 
ATOM   1823 C  C   . THR B 1 45  ? -34.07422 42.28813 -22.50920 1.000 94.98000  ? 25  THR B C   1 
ATOM   1824 O  O   . THR B 1 45  ? -33.47651 42.59576 -21.46818 1.000 90.39000  ? 25  THR B O   1 
ATOM   1825 C  CB  . THR B 1 45  ? -32.57687 42.07491 -24.52527 1.000 87.97000  ? 25  THR B CB  1 
ATOM   1826 O  OG1 . THR B 1 45  ? -31.86970 41.12238 -25.32351 1.000 91.90000  ? 25  THR B OG1 1 
ATOM   1827 C  CG2 . THR B 1 45  ? -31.56638 42.99321 -23.83899 1.000 86.30000  ? 25  THR B CG2 1 
ATOM   1828 N  N   . PHE B 1 46  ? -35.29651 42.74601 -22.79439 1.000 93.15000  ? 26  PHE B N   1 
ATOM   1829 C  CA  . PHE B 1 46  ? -35.95089 43.71041 -21.91692 1.000 91.08000  ? 26  PHE B CA  1 
ATOM   1830 C  C   . PHE B 1 46  ? -36.14489 43.12750 -20.52003 1.000 95.55000  ? 26  PHE B C   1 
ATOM   1831 O  O   . PHE B 1 46  ? -35.80920 43.76603 -19.51599 1.000 94.20000  ? 26  PHE B O   1 
ATOM   1832 C  CB  . PHE B 1 46  ? -37.28023 44.15432 -22.54749 1.000 92.12000  ? 26  PHE B CB  1 
ATOM   1833 C  CG  . PHE B 1 46  ? -38.13090 45.05174 -21.66788 1.000 94.48000  ? 26  PHE B CG  1 
ATOM   1834 C  CD1 . PHE B 1 46  ? -38.71770 44.58198 -20.48695 1.000 97.54000  ? 26  PHE B CD1 1 
ATOM   1835 C  CD2 . PHE B 1 46  ? -38.31580 46.38205 -22.00845 1.000 94.91000  ? 26  PHE B CD2 1 
ATOM   1836 C  CE1 . PHE B 1 46  ? -39.49017 45.41129 -19.68977 1.000 95.07000  ? 26  PHE B CE1 1 
ATOM   1837 C  CE2 . PHE B 1 46  ? -39.07927 47.21491 -21.21182 1.000 94.43000  ? 26  PHE B CE2 1 
ATOM   1838 C  CZ  . PHE B 1 46  ? -39.66629 46.73037 -20.05354 1.000 95.81000  ? 26  PHE B CZ  1 
ATOM   1839 N  N   . TYR B 1 47  ? -36.69191 41.91395 -20.43520 1.000 92.42000  ? 27  TYR B N   1 
ATOM   1840 C  CA  . TYR B 1 47  ? -36.90270 41.30474 -19.12923 1.000 92.68000  ? 27  TYR B CA  1 
ATOM   1841 C  C   . TYR B 1 47  ? -35.61610 40.70640 -18.58562 1.000 91.96000  ? 27  TYR B C   1 
ATOM   1842 O  O   . TYR B 1 47  ? -35.46901 40.56964 -17.36708 1.000 92.13000  ? 27  TYR B O   1 
ATOM   1843 C  CB  . TYR B 1 47  ? -38.01184 40.25367 -19.21309 1.000 89.87000  ? 27  TYR B CB  1 
ATOM   1844 C  CG  . TYR B 1 47  ? -39.39320 40.85857 -19.35803 1.000 89.88000  ? 27  TYR B CG  1 
ATOM   1845 C  CD1 . TYR B 1 47  ? -39.85326 41.81271 -18.46424 1.000 94.77000  ? 27  TYR B CD1 1 
ATOM   1846 C  CD2 . TYR B 1 47  ? -40.21831 40.50467 -20.40722 1.000 88.68000  ? 27  TYR B CD2 1 
ATOM   1847 C  CE1 . TYR B 1 47  ? -41.11200 42.37304 -18.59849 1.000 97.30000  ? 27  TYR B CE1 1 
ATOM   1848 C  CE2 . TYR B 1 47  ? -41.47091 41.06407 -20.54956 1.000 90.09000  ? 27  TYR B CE2 1 
ATOM   1849 C  CZ  . TYR B 1 47  ? -41.91197 41.99458 -19.64620 1.000 91.19000  ? 27  TYR B CZ  1 
ATOM   1850 O  OH  . TYR B 1 47  ? -43.15908 42.54661 -19.79524 1.000 92.66000  ? 27  TYR B OH  1 
ATOM   1851 N  N   . VAL B 1 48  ? -34.67484 40.35264 -19.46458 1.000 93.26000  ? 28  VAL B N   1 
ATOM   1852 C  CA  . VAL B 1 48  ? -33.31693 40.07955 -19.00374 1.000 97.09000  ? 28  VAL B CA  1 
ATOM   1853 C  C   . VAL B 1 48  ? -32.74086 41.32024 -18.33469 1.000 94.05000  ? 28  VAL B C   1 
ATOM   1854 O  O   . VAL B 1 48  ? -32.25334 41.26545 -17.20243 1.000 94.00000  ? 28  VAL B O   1 
ATOM   1855 C  CB  . VAL B 1 48  ? -32.43312 39.60001 -20.16718 1.000 94.51000  ? 28  VAL B CB  1 
ATOM   1856 N  N   . LYS B 1 49  ? -32.81520 42.46698 -19.01772 1.000 94.68000  ? 29  LYS B N   1 
ATOM   1857 C  CA  . LYS B 1 49  ? -32.42825 43.73120 -18.39573 1.000 91.90000  ? 29  LYS B CA  1 
ATOM   1858 C  C   . LYS B 1 49  ? -33.22431 43.98092 -17.11642 1.000 94.83000  ? 29  LYS B C   1 
ATOM   1859 O  O   . LYS B 1 49  ? -32.73818 44.65490 -16.20030 1.000 96.11000  ? 29  LYS B O   1 
ATOM   1860 C  CB  . LYS B 1 49  ? -32.61573 44.90152 -19.38994 1.000 31.63000  ? 29  LYS B CB  1 
ATOM   1861 C  CG  . LYS B 1 49  ? -31.59385 44.96979 -20.65384 1.000 31.63000  ? 29  LYS B CG  1 
ATOM   1862 N  N   . TRP B 1 50  ? -34.43982 43.43300 -17.02845 1.000 93.23000  ? 30  TRP B N   1 
ATOM   1863 C  CA  . TRP B 1 50  ? -35.26066 43.60734 -15.83498 1.000 93.59000  ? 30  TRP B CA  1 
ATOM   1864 C  C   . TRP B 1 50  ? -34.81495 42.67504 -14.71214 1.000 95.49000  ? 30  TRP B C   1 
ATOM   1865 O  O   . TRP B 1 50  ? -34.63007 43.10803 -13.56464 1.000 91.97000  ? 30  TRP B O   1 
ATOM   1866 C  CB  . TRP B 1 50  ? -36.73329 43.37224 -16.18203 1.000 92.20000  ? 30  TRP B CB  1 
ATOM   1867 C  CG  . TRP B 1 50  ? -37.70508 43.65328 -15.05908 1.000 87.05000  ? 30  TRP B CG  1 
ATOM   1868 C  CD1 . TRP B 1 50  ? -37.63718 43.19664 -13.76956 1.000 88.09000  ? 30  TRP B CD1 1 
ATOM   1869 C  CD2 . TRP B 1 50  ? -38.88093 44.46579 -15.12877 1.000 89.40000  ? 30  TRP B CD2 1 
ATOM   1870 N  NE1 . TRP B 1 50  ? -38.69690 43.66613 -13.04452 1.000 89.66000  ? 30  TRP B NE1 1 
ATOM   1871 C  CE2 . TRP B 1 50  ? -39.47538 44.45126 -13.85169 1.000 91.78000  ? 30  TRP B CE2 1 
ATOM   1872 C  CE3 . TRP B 1 50  ? -39.49876 45.19544 -16.15089 1.000 95.16000  ? 30  TRP B CE3 1 
ATOM   1873 C  CZ2 . TRP B 1 50  ? -40.64829 45.14978 -13.56528 1.000 92.50000  ? 30  TRP B CZ2 1 
ATOM   1874 C  CZ3 . TRP B 1 50  ? -40.67424 45.88727 -15.86280 1.000 92.20000  ? 30  TRP B CZ3 1 
ATOM   1875 C  CH2 . TRP B 1 50  ? -41.23153 45.85872 -14.58355 1.000 93.51000  ? 30  TRP B CH2 1 
ATOM   1876 N  N   . SER B 1 51  ? -34.65450 41.38647 -15.02660 1.000 93.88000  ? 31  SER B N   1 
ATOM   1877 C  CA  . SER B 1 51  ? -34.25035 40.41336 -14.01709 1.000 95.16000  ? 31  SER B CA  1 
ATOM   1878 C  C   . SER B 1 51  ? -32.98632 40.84795 -13.28274 1.000 98.54000  ? 31  SER B C   1 
ATOM   1879 O  O   . SER B 1 51  ? -32.80955 40.52244 -12.10286 1.000 103.86000 ? 31  SER B O   1 
ATOM   1880 C  CB  . SER B 1 51  ? -34.04335 39.04389 -14.67246 1.000 92.47000  ? 31  SER B CB  1 
ATOM   1881 N  N   . LYS B 1 52  ? -32.10716 41.59270 -13.95576 1.000 97.67000  ? 32  LYS B N   1 
ATOM   1882 C  CA  . LYS B 1 52  ? -30.84153 42.04677 -13.39516 1.000 100.29000 ? 32  LYS B CA  1 
ATOM   1883 C  C   . LYS B 1 52  ? -30.85548 43.53106 -13.02777 1.000 100.52000 ? 32  LYS B C   1 
ATOM   1884 O  O   . LYS B 1 52  ? -29.80137 44.08859 -12.70572 1.000 101.51000 ? 32  LYS B O   1 
ATOM   1885 C  CB  . LYS B 1 52  ? -29.70023 41.75129 -14.37631 1.000 87.76000  ? 32  LYS B CB  1 
ATOM   1886 N  N   . GLY B 1 53  ? -32.01831 44.18276 -13.07131 1.000 100.96000 ? 33  GLY B N   1 
ATOM   1887 C  CA  . GLY B 1 53  ? -32.12400 45.57935 -12.68523 1.000 94.87000  ? 33  GLY B CA  1 
ATOM   1888 C  C   . GLY B 1 53  ? -31.66763 46.56869 -13.74086 1.000 98.16000  ? 33  GLY B C   1 
ATOM   1889 O  O   . GLY B 1 53  ? -32.09433 47.72691 -13.73906 1.000 103.59000 ? 33  GLY B O   1 
ATOM   1890 N  N   . GLU B 1 54  ? -30.80291 46.11606 -14.65114 1.000 97.00000  ? 34  GLU B N   1 
ATOM   1891 C  CA  . GLU B 1 54  ? -30.20388 46.92994 -15.70926 1.000 95.19000  ? 34  GLU B CA  1 
ATOM   1892 C  C   . GLU B 1 54  ? -31.24487 47.55440 -16.65065 1.000 96.07000  ? 34  GLU B C   1 
ATOM   1893 O  O   . GLU B 1 54  ? -31.14166 47.41743 -17.87597 1.000 96.35000  ? 34  GLU B O   1 
ATOM   1894 C  CB  . GLU B 1 54  ? -29.20022 46.06369 -16.51064 1.000 34.08000  ? 34  GLU B CB  1 
ATOM   1895 C  CG  . GLU B 1 54  ? -27.71620 46.04806 -16.00384 1.000 34.08000  ? 34  GLU B CG  1 
ATOM   1896 N  N   . LEU B 1 55  ? -32.25213 48.23179 -16.09061 1.000 92.28000  ? 35  LEU B N   1 
ATOM   1897 C  CA  . LEU B 1 55  ? -33.24423 49.00435 -16.83367 1.000 92.35000  ? 35  LEU B CA  1 
ATOM   1898 C  C   . LEU B 1 55  ? -33.32961 50.38611 -16.20363 1.000 94.04000  ? 35  LEU B C   1 
ATOM   1899 O  O   . LEU B 1 55  ? -32.69493 50.65804 -15.18046 1.000 96.87000  ? 35  LEU B O   1 
ATOM   1900 C  CB  . LEU B 1 55  ? -34.63036 48.33179 -16.83400 1.000 34.08000  ? 35  LEU B CB  1 
ATOM   1901 C  CG  . LEU B 1 55  ? -35.45241 48.34243 -18.16217 1.000 34.08000  ? 35  LEU B CG  1 
ATOM   1902 N  N   . THR B 1 56  ? -34.10505 51.28048 -16.81619 1.000 95.12000  ? 36  THR B N   1 
ATOM   1903 C  CA  . THR B 1 56  ? -34.22398 52.63461 -16.29033 1.000 98.49000  ? 36  THR B CA  1 
ATOM   1904 C  C   . THR B 1 56  ? -35.68269 53.02936 -16.11049 1.000 98.07000  ? 36  THR B C   1 
ATOM   1905 O  O   . THR B 1 56  ? -36.58708 52.48878 -16.75426 1.000 98.07000  ? 36  THR B O   1 
ATOM   1906 C  CB  . THR B 1 56  ? -33.52573 53.67576 -17.18049 1.000 101.69000 ? 36  THR B CB  1 
ATOM   1907 O  OG1 . THR B 1 56  ? -34.43084 54.13130 -18.19387 1.000 105.15000 ? 36  THR B OG1 1 
ATOM   1908 C  CG2 . THR B 1 56  ? -32.27222 53.09965 -17.80976 1.000 94.97000  ? 36  THR B CG2 1 
ATOM   1909 N  N   . LYS B 1 57  ? -35.88976 53.99848 -15.21418 1.000 96.59000  ? 37  LYS B N   1 
ATOM   1910 C  CA  . LYS B 1 57  ? -37.22516 54.53999 -14.99423 1.000 103.87000 ? 37  LYS B CA  1 
ATOM   1911 C  C   . LYS B 1 57  ? -37.82632 55.05651 -16.29489 1.000 99.15000  ? 37  LYS B C   1 
ATOM   1912 O  O   . LYS B 1 57  ? -38.94843 54.68968 -16.66188 1.000 99.01000  ? 37  LYS B O   1 
ATOM   1913 C  CB  . LYS B 1 57  ? -37.17311 55.65065 -13.94716 1.000 102.54000 ? 37  LYS B CB  1 
ATOM   1914 N  N   . GLU B 1 58  ? -37.08184 55.89828 -17.01629 1.000 102.15000 ? 38  GLU B N   1 
ATOM   1915 C  CA  . GLU B 1 58  ? -37.58945 56.44849 -18.26882 1.000 99.70000  ? 38  GLU B CA  1 
ATOM   1916 C  C   . GLU B 1 58  ? -37.99155 55.34951 -19.24064 1.000 98.91000  ? 38  GLU B C   1 
ATOM   1917 O  O   . GLU B 1 58  ? -38.92780 55.53049 -20.02992 1.000 95.89000  ? 38  GLU B O   1 
ATOM   1918 C  CB  . GLU B 1 58  ? -36.54153 57.37079 -18.89453 1.000 103.11000 ? 38  GLU B CB  1 
ATOM   1919 C  CG  . GLU B 1 58  ? -36.08597 58.49150 -17.96912 1.000 103.45000 ? 38  GLU B CG  1 
ATOM   1920 C  CD  . GLU B 1 58  ? -34.74810 58.21375 -17.32060 1.000 104.62000 ? 38  GLU B CD  1 
ATOM   1921 O  OE1 . GLU B 1 58  ? -34.55640 57.09933 -16.78747 1.000 101.59000 ? 38  GLU B OE1 1 
ATOM   1922 O  OE2 . GLU B 1 58  ? -33.89342 59.12252 -17.33434 1.000 110.47000 ? 38  GLU B OE2 1 
ATOM   1923 N  N   . GLN B 1 59  ? -37.31243 54.20194 -19.18654 1.000 96.31000  ? 39  GLN B N   1 
ATOM   1924 C  CA  . GLN B 1 59  ? -37.70540 53.06676 -20.01393 1.000 94.41000  ? 39  GLN B CA  1 
ATOM   1925 C  C   . GLN B 1 59  ? -39.03057 52.47321 -19.54363 1.000 94.36000  ? 39  GLN B C   1 
ATOM   1926 O  O   . GLN B 1 59  ? -39.94490 52.24489 -20.34558 1.000 85.71000  ? 39  GLN B O   1 
ATOM   1927 C  CB  . GLN B 1 59  ? -36.60767 52.00247 -19.99708 1.000 96.31000  ? 39  GLN B CB  1 
ATOM   1928 C  CG  . GLN B 1 59  ? -35.62582 52.08157 -21.15876 1.000 94.56000  ? 39  GLN B CG  1 
ATOM   1929 C  CD  . GLN B 1 59  ? -34.21295 51.63291 -20.78534 1.000 98.91000  ? 39  GLN B CD  1 
ATOM   1930 O  OE1 . GLN B 1 59  ? -33.97507 50.46311 -20.47482 1.000 103.16000 ? 39  GLN B OE1 1 
ATOM   1931 N  NE2 . GLN B 1 59  ? -33.26989 52.56955 -20.81707 1.000 90.18000  ? 39  GLN B NE2 1 
ATOM   1932 N  N   . LEU B 1 60  ? -39.15792 52.21078 -18.24223 1.000 95.29000  ? 40  LEU B N   1 
ATOM   1933 C  CA  . LEU B 1 60  ? -40.36158 51.53458 -17.77119 1.000 90.41000  ? 40  LEU B CA  1 
ATOM   1934 C  C   . LEU B 1 60  ? -41.57336 52.45133 -17.84793 1.000 87.33000  ? 40  LEU B C   1 
ATOM   1935 O  O   . LEU B 1 60  ? -42.69414 51.97211 -18.03892 1.000 82.29000  ? 40  LEU B O   1 
ATOM   1936 C  CB  . LEU B 1 60  ? -40.15050 50.98631 -16.34968 1.000 37.17000  ? 40  LEU B CB  1 
ATOM   1937 N  N   . GLN B 1 61  ? -41.37255 53.76428 -17.72889 1.000 85.26000  ? 41  GLN B N   1 
ATOM   1938 C  CA  . GLN B 1 61  ? -42.46932 54.69353 -17.99043 1.000 86.77000  ? 41  GLN B CA  1 
ATOM   1939 C  C   . GLN B 1 61  ? -42.89501 54.65274 -19.45170 1.000 86.36000  ? 41  GLN B C   1 
ATOM   1940 O  O   . GLN B 1 61  ? -44.07976 54.82006 -19.76095 1.000 84.86000  ? 41  GLN B O   1 
ATOM   1941 C  CB  . GLN B 1 61  ? -42.07215 56.12040 -17.61022 1.000 85.69000  ? 41  GLN B CB  1 
ATOM   1942 C  CG  . GLN B 1 61  ? -41.89032 56.37312 -16.12446 1.000 87.74000  ? 41  GLN B CG  1 
ATOM   1943 C  CD  . GLN B 1 61  ? -41.26853 57.72549 -15.85510 1.000 90.24000  ? 41  GLN B CD  1 
ATOM   1944 O  OE1 . GLN B 1 61  ? -41.93852 58.75773 -15.94578 1.000 89.98000  ? 41  GLN B OE1 1 
ATOM   1945 N  NE2 . GLN B 1 61  ? -39.97376 57.72986 -15.52904 1.000 92.01000  ? 41  GLN B NE2 1 
ATOM   1946 N  N   . ALA B 1 62  ? -41.94164 54.45706 -20.36234 1.000 88.59000  ? 42  ALA B N   1 
ATOM   1947 C  CA  . ALA B 1 62  ? -42.28982 54.25456 -21.75872 1.000 83.60000  ? 42  ALA B CA  1 
ATOM   1948 C  C   . ALA B 1 62  ? -42.97226 52.91105 -21.95693 1.000 81.25000  ? 42  ALA B C   1 
ATOM   1949 O  O   . ALA B 1 62  ? -43.82964 52.77085 -22.83748 1.000 82.35000  ? 42  ALA B O   1 
ATOM   1950 C  CB  . ALA B 1 62  ? -41.03445 54.35949 -22.62306 1.000 84.47000  ? 42  ALA B CB  1 
ATOM   1951 N  N   . TYR B 1 63  ? -42.61019 51.91853 -21.14282 1.000 81.33000  ? 43  TYR B N   1 
ATOM   1952 C  CA  . TYR B 1 63  ? -43.23235 50.60572 -21.25481 1.000 80.47000  ? 43  TYR B CA  1 
ATOM   1953 C  C   . TYR B 1 63  ? -44.65983 50.62962 -20.72929 1.000 78.11000  ? 43  TYR B C   1 
ATOM   1954 O  O   . TYR B 1 63  ? -45.57347 50.09830 -21.37407 1.000 74.15000  ? 43  TYR B O   1 
ATOM   1955 C  CB  . TYR B 1 63  ? -42.37723 49.57544 -20.52097 1.000 85.27000  ? 43  TYR B CB  1 
ATOM   1956 C  CG  . TYR B 1 63  ? -43.07314 48.29076 -20.12570 1.000 87.09000  ? 43  TYR B CG  1 
ATOM   1957 C  CD1 . TYR B 1 63  ? -43.33916 47.28957 -21.06229 1.000 83.81000  ? 43  TYR B CD1 1 
ATOM   1958 C  CD2 . TYR B 1 63  ? -43.40179 48.05039 -18.79634 1.000 86.36000  ? 43  TYR B CD2 1 
ATOM   1959 C  CE1 . TYR B 1 63  ? -43.95658 46.10186 -20.67958 1.000 88.37000  ? 43  TYR B CE1 1 
ATOM   1960 C  CE2 . TYR B 1 63  ? -44.01670 46.87655 -18.40332 1.000 84.82000  ? 43  TYR B CE2 1 
ATOM   1961 C  CZ  . TYR B 1 63  ? -44.29276 45.90381 -19.33636 1.000 90.85000  ? 43  TYR B CZ  1 
ATOM   1962 O  OH  . TYR B 1 63  ? -44.90559 44.74342 -18.90247 1.000 92.23000  ? 43  TYR B OH  1 
ATOM   1963 N  N   . ALA B 1 64  ? -44.88000 51.28952 -19.58960 1.000 79.63000  ? 44  ALA B N   1 
ATOM   1964 C  CA  . ALA B 1 64  ? -46.20805 51.30298 -18.98350 1.000 73.44000  ? 44  ALA B CA  1 
ATOM   1965 C  C   . ALA B 1 64  ? -47.20634 52.07571 -19.83580 1.000 73.52000  ? 44  ALA B C   1 
ATOM   1966 O  O   . ALA B 1 64  ? -48.36705 51.66583 -19.96473 1.000 74.43000  ? 44  ALA B O   1 
ATOM   1967 C  CB  . ALA B 1 64  ? -46.13912 51.89298 -17.57841 1.000 71.61000  ? 44  ALA B CB  1 
ATOM   1968 N  N   . LYS B 1 65  ? -46.77924 53.19827 -20.42143 1.000 75.77000  ? 45  LYS B N   1 
ATOM   1969 C  CA  . LYS B 1 65  ? -47.69853 53.99625 -21.22270 1.000 75.99000  ? 45  LYS B CA  1 
ATOM   1970 C  C   . LYS B 1 65  ? -48.04123 53.28995 -22.52607 1.000 73.78000  ? 45  LYS B C   1 
ATOM   1971 O  O   . LYS B 1 65  ? -49.21300 53.23881 -22.91992 1.000 71.46000  ? 45  LYS B O   1 
ATOM   1972 C  CB  . LYS B 1 65  ? -47.10076 55.37910 -21.49342 0.441 82.36000  ? 45  LYS B CB  1 
ATOM   1973 C  CG  . LYS B 1 65  ? -46.88278 56.23986 -20.25020 1.000 78.98000  ? 45  LYS B CG  1 
ATOM   1974 C  CD  . LYS B 1 65  ? -46.40174 57.64580 -20.61684 1.000 82.60000  ? 45  LYS B CD  1 
ATOM   1975 N  N   . ASP B 1 66  ? -47.02939 52.71988 -23.19351 1.000 74.26000  ? 46  ASP B N   1 
ATOM   1976 C  CA  . ASP B 1 66  ? -47.23020 52.06399 -24.48541 1.000 76.44000  ? 46  ASP B CA  1 
ATOM   1977 C  C   . ASP B 1 66  ? -48.11490 50.82481 -24.35847 1.000 76.39000  ? 46  ASP B C   1 
ATOM   1978 O  O   . ASP B 1 66  ? -48.89019 50.51764 -25.27380 1.000 71.68000  ? 46  ASP B O   1 
ATOM   1979 C  CB  . ASP B 1 66  ? -45.87153 51.69515 -25.08897 1.000 80.33000  ? 46  ASP B CB  1 
ATOM   1980 C  CG  . ASP B 1 66  ? -45.73666 52.12107 -26.54401 1.000 81.79000  ? 46  ASP B CG  1 
ATOM   1981 O  OD1 . ASP B 1 66  ? -46.65013 52.79559 -27.06152 1.000 81.66000  ? 46  ASP B OD1 1 
ATOM   1982 O  OD2 . ASP B 1 66  ? -44.71301 51.77033 -27.17349 1.000 89.35000  ? 46  ASP B OD2 1 
ATOM   1983 N  N   . TYR B 1 67  ? -47.99791 50.09372 -23.23344 1.000 73.58000  ? 47  TYR B N   1 
ATOM   1984 C  CA  . TYR B 1 67  ? -48.82664 48.91327 -22.97151 1.000 71.58000  ? 47  TYR B CA  1 
ATOM   1985 C  C   . TYR B 1 67  ? -50.30014 49.25614 -22.84039 1.000 68.06000  ? 47  TYR B C   1 
ATOM   1986 O  O   . TYR B 1 67  ? -51.15453 48.37701 -23.00525 1.000 68.92000  ? 47  TYR B O   1 
ATOM   1987 C  CB  . TYR B 1 67  ? -48.37890 48.21703 -21.68051 1.000 74.28000  ? 47  TYR B CB  1 
ATOM   1988 C  CG  . TYR B 1 67  ? -48.24939 46.70701 -21.75912 1.000 72.27000  ? 47  TYR B CG  1 
ATOM   1989 C  CD1 . TYR B 1 67  ? -47.06161 46.11700 -22.12643 1.000 73.77000  ? 47  TYR B CD1 1 
ATOM   1990 C  CD2 . TYR B 1 67  ? -49.30169 45.87745 -21.43744 1.000 73.64000  ? 47  TYR B CD2 1 
ATOM   1991 C  CE1 . TYR B 1 67  ? -46.93270 44.74466 -22.19534 1.000 72.95000  ? 47  TYR B CE1 1 
ATOM   1992 C  CE2 . TYR B 1 67  ? -49.18426 44.50665 -21.49711 1.000 77.73000  ? 47  TYR B CE2 1 
ATOM   1993 C  CZ  . TYR B 1 67  ? -47.99353 43.94614 -21.87999 1.000 77.75000  ? 47  TYR B CZ  1 
ATOM   1994 O  OH  . TYR B 1 67  ? -47.84243 42.58335 -21.94333 1.000 79.84000  ? 47  TYR B OH  1 
ATOM   1995 N  N   . TYR B 1 68  ? -50.61523 50.51732 -22.56012 1.000 69.84000  ? 48  TYR B N   1 
ATOM   1996 C  CA  . TYR B 1 68  ? -51.97433 50.87370 -22.17580 1.000 71.51000  ? 48  TYR B CA  1 
ATOM   1997 C  C   . TYR B 1 68  ? -52.97935 50.63848 -23.29344 1.000 71.12000  ? 48  TYR B C   1 
ATOM   1998 O  O   . TYR B 1 68  ? -54.15798 50.37582 -23.02752 1.000 61.66000  ? 48  TYR B O   1 
ATOM   1999 C  CB  . TYR B 1 68  ? -52.01408 52.32661 -21.72345 1.000 77.45000  ? 48  TYR B CB  1 
ATOM   2000 C  CG  . TYR B 1 68  ? -53.27971 52.67676 -21.00058 1.000 79.79000  ? 48  TYR B CG  1 
ATOM   2001 C  CD1 . TYR B 1 68  ? -53.80343 51.82900 -20.03471 1.000 70.01000  ? 48  TYR B CD1 1 
ATOM   2002 C  CD2 . TYR B 1 68  ? -53.94752 53.85921 -21.28077 1.000 81.17000  ? 48  TYR B CD2 1 
ATOM   2003 C  CE1 . TYR B 1 68  ? -54.96981 52.14537 -19.37433 1.000 77.15000  ? 48  TYR B CE1 1 
ATOM   2004 C  CE2 . TYR B 1 68  ? -55.10756 54.19335 -20.62751 1.000 80.07000  ? 48  TYR B CE2 1 
ATOM   2005 C  CZ  . TYR B 1 68  ? -55.61820 53.33805 -19.66607 1.000 84.81000  ? 48  TYR B CZ  1 
ATOM   2006 O  OH  . TYR B 1 68  ? -56.78735 53.68379 -19.01184 1.000 81.46000  ? 48  TYR B OH  1 
ATOM   2007 N  N   . LEU B 1 69  ? -52.54425 50.73299 -24.54246 1.000 67.18000  ? 49  LEU B N   1 
ATOM   2008 C  CA  . LEU B 1 69  ? -53.44808 50.43727 -25.63969 1.000 64.58000  ? 49  LEU B CA  1 
ATOM   2009 C  C   . LEU B 1 69  ? -53.94665 49.00203 -25.55897 1.000 65.07000  ? 49  LEU B C   1 
ATOM   2010 O  O   . LEU B 1 69  ? -55.14000 48.72640 -25.76899 1.000 63.28000  ? 49  LEU B O   1 
ATOM   2011 C  CB  . LEU B 1 69  ? -52.72876 50.69225 -26.95737 1.000 66.94000  ? 49  LEU B CB  1 
ATOM   2012 C  CG  . LEU B 1 69  ? -53.48091 50.27589 -28.20056 1.000 58.72000  ? 49  LEU B CG  1 
ATOM   2013 C  CD1 . LEU B 1 69  ? -54.54647 51.29395 -28.49209 1.000 60.61000  ? 49  LEU B CD1 1 
ATOM   2014 C  CD2 . LEU B 1 69  ? -52.48740 50.18869 -29.30527 1.000 65.12000  ? 49  LEU B CD2 1 
ATOM   2015 N  N   . HIS B 1 70  ? -53.03882 48.08410 -25.22289 1.000 65.07000  ? 50  HIS B N   1 
ATOM   2016 C  CA  . HIS B 1 70  ? -53.34795 46.66164 -25.14597 1.000 66.20000  ? 50  HIS B CA  1 
ATOM   2017 C  C   . HIS B 1 70  ? -54.30144 46.36374 -23.99982 1.000 61.42000  ? 50  HIS B C   1 
ATOM   2018 O  O   . HIS B 1 70  ? -55.29115 45.63729 -24.16420 1.000 60.79000  ? 50  HIS B O   1 
ATOM   2019 C  CB  . HIS B 1 70  ? -52.03922 45.89921 -24.97174 1.000 66.20000  ? 50  HIS B CB  1 
ATOM   2020 C  CG  . HIS B 1 70  ? -52.18847 44.41285 -24.92891 1.000 63.93000  ? 50  HIS B CG  1 
ATOM   2021 N  ND1 . HIS B 1 70  ? -52.80187 43.69379 -25.93605 1.000 69.26000  ? 50  HIS B ND1 1 
ATOM   2022 C  CD2 . HIS B 1 70  ? -51.76192 43.50532 -24.01967 1.000 61.02000  ? 50  HIS B CD2 1 
ATOM   2023 C  CE1 . HIS B 1 70  ? -52.75755 42.40763 -25.64222 1.000 67.63000  ? 50  HIS B CE1 1 
ATOM   2024 N  NE2 . HIS B 1 70  ? -52.13243 42.26646 -24.48375 1.000 69.94000  ? 50  HIS B NE2 1 
ATOM   2025 N  N   . ILE B 1 71  ? -53.99902 46.90991 -22.82155 1.000 63.08000  ? 51  ILE B N   1 
ATOM   2026 C  CA  . ILE B 1 71  ? -54.85880 46.73956 -21.65243 1.000 64.50000  ? 51  ILE B CA  1 
ATOM   2027 C  C   . ILE B 1 71  ? -56.28451 47.17312 -21.95448 1.000 59.75000  ? 51  ILE B C   1 
ATOM   2028 O  O   . ILE B 1 71  ? -57.23954 46.48844 -21.58382 1.000 54.95000  ? 51  ILE B O   1 
ATOM   2029 C  CB  . ILE B 1 71  ? -54.26853 47.50047 -20.44775 1.000 66.88000  ? 51  ILE B CB  1 
ATOM   2030 C  CG1 . ILE B 1 71  ? -53.03783 46.76492 -19.91647 1.000 61.06000  ? 51  ILE B CG1 1 
ATOM   2031 C  CG2 . ILE B 1 71  ? -55.29475 47.70599 -19.35287 1.000 63.07000  ? 51  ILE B CG2 1 
ATOM   2032 C  CD1 . ILE B 1 71  ? -51.77714 47.50371 -20.17958 1.000 61.86000  ? 51  ILE B CD1 1 
ATOM   2033 N  N   . LYS B 1 72  ? -56.46063 48.30058 -22.64374 1.000 68.48000  ? 52  LYS B N   1 
ATOM   2034 C  CA  . LYS B 1 72  ? -57.81921 48.73157 -22.96008 1.000 59.82000  ? 52  LYS B CA  1 
ATOM   2035 C  C   . LYS B 1 72  ? -58.48564 47.79375 -23.96357 1.000 64.17000  ? 52  LYS B C   1 
ATOM   2036 O  O   . LYS B 1 72  ? -59.71770 47.67073 -23.98805 1.000 63.01000  ? 52  LYS B O   1 
ATOM   2037 C  CB  . LYS B 1 72  ? -57.80478 50.14236 -23.53270 1.000 58.01000  ? 52  LYS B CB  1 
ATOM   2038 C  CG  . LYS B 1 72  ? -57.38265 51.24179 -22.59877 1.000 64.38000  ? 52  LYS B CG  1 
ATOM   2039 C  CD  . LYS B 1 72  ? -57.71481 52.53042 -23.24693 1.000 61.29000  ? 52  LYS B CD  1 
ATOM   2040 C  CE  . LYS B 1 72  ? -56.47935 53.36715 -23.48526 1.000 68.63000  ? 52  LYS B CE  1 
ATOM   2041 N  NZ  . LYS B 1 72  ? -56.71856 54.45049 -24.50340 1.000 71.19000  ? 52  LYS B NZ  1 
ATOM   2042 N  N   . ALA B 1 73  ? -57.68539 47.12748 -24.79477 1.000 57.17000  ? 53  ALA B N   1 
ATOM   2043 C  CA  . ALA B 1 73  ? -58.21134 46.36452 -25.91052 1.000 60.96000  ? 53  ALA B CA  1 
ATOM   2044 C  C   . ALA B 1 73  ? -58.52085 44.93212 -25.53525 1.000 58.98000  ? 53  ALA B C   1 
ATOM   2045 O  O   . ALA B 1 73  ? -59.42732 44.33555 -26.12354 1.000 57.68000  ? 53  ALA B O   1 
ATOM   2046 C  CB  . ALA B 1 73  ? -57.21785 46.40080 -27.07283 1.000 58.79000  ? 53  ALA B CB  1 
ATOM   2047 N  N   . PHE B 1 74  ? -57.83062 44.38923 -24.53286 1.000 61.20000  ? 54  PHE B N   1 
ATOM   2048 C  CA  . PHE B 1 74  ? -57.99762 42.97577 -24.19296 1.000 57.11000  ? 54  PHE B CA  1 
ATOM   2049 C  C   . PHE B 1 74  ? -59.44734 42.51145 -24.02194 1.000 59.08000  ? 54  PHE B C   1 
ATOM   2050 O  O   . PHE B 1 74  ? -59.76343 41.40442 -24.49144 1.000 56.10000  ? 54  PHE B O   1 
ATOM   2051 C  CB  . PHE B 1 74  ? -57.18988 42.61820 -22.93591 1.000 58.37000  ? 54  PHE B CB  1 
ATOM   2052 C  CG  . PHE B 1 74  ? -56.72205 41.20112 -22.94038 1.000 64.05000  ? 54  PHE B CG  1 
ATOM   2053 C  CD1 . PHE B 1 74  ? -57.53843 40.18529 -22.45287 1.000 66.00000  ? 54  PHE B CD1 1 
ATOM   2054 C  CD2 . PHE B 1 74  ? -55.49497 40.86400 -23.48717 1.000 63.37000  ? 54  PHE B CD2 1 
ATOM   2055 C  CE1 . PHE B 1 74  ? -57.12564 38.86050 -22.48856 1.000 62.42000  ? 54  PHE B CE1 1 
ATOM   2056 C  CE2 . PHE B 1 74  ? -55.06904 39.53734 -23.53588 1.000 67.84000  ? 54  PHE B CE2 1 
ATOM   2057 C  CZ  . PHE B 1 74  ? -55.88053 38.54077 -23.03825 1.000 67.40000  ? 54  PHE B CZ  1 
ATOM   2058 N  N   . PRO B 1 75  ? -60.35771 43.25472 -23.37981 1.000 58.03000  ? 55  PRO B N   1 
ATOM   2059 C  CA  . PRO B 1 75  ? -61.74386 42.77044 -23.31250 1.000 54.68000  ? 55  PRO B CA  1 
ATOM   2060 C  C   . PRO B 1 75  ? -62.39014 42.58082 -24.67274 1.000 58.27000  ? 55  PRO B C   1 
ATOM   2061 O  O   . PRO B 1 75  ? -63.25986 41.71046 -24.80489 1.000 59.88000  ? 55  PRO B O   1 
ATOM   2062 C  CB  . PRO B 1 75  ? -62.45906 43.85882 -22.50684 1.000 57.51000  ? 55  PRO B CB  1 
ATOM   2063 C  CG  . PRO B 1 75  ? -61.38792 44.52689 -21.74458 1.000 63.58000  ? 55  PRO B CG  1 
ATOM   2064 C  CD  . PRO B 1 75  ? -60.18555 44.50439 -22.61996 1.000 58.07000  ? 55  PRO B CD  1 
ATOM   2065 N  N   . LYS B 1 76  ? -62.01914 43.39356 -25.67621 1.000 58.59000  ? 56  LYS B N   1 
ATOM   2066 C  CA  . LYS B 1 76  ? -62.55329 43.21033 -27.03062 1.000 59.14000  ? 56  LYS B CA  1 
ATOM   2067 C  C   . LYS B 1 76  ? -62.13593 41.86840 -27.62123 1.000 56.82000  ? 56  LYS B C   1 
ATOM   2068 O  O   . LYS B 1 76  ? -62.94292 41.21604 -28.29430 1.000 55.05000  ? 56  LYS B O   1 
ATOM   2069 C  CB  . LYS B 1 76  ? -62.11384 44.34569 -27.96672 1.000 63.93000  ? 56  LYS B CB  1 
ATOM   2070 C  CG  . LYS B 1 76  ? -62.64456 45.73263 -27.62113 1.000 63.04000  ? 56  LYS B CG  1 
ATOM   2071 C  CD  . LYS B 1 76  ? -61.78993 46.84556 -28.21863 1.000 66.85000  ? 56  LYS B CD  1 
ATOM   2072 C  CE  . LYS B 1 76  ? -62.32270 47.33535 -29.54813 1.000 68.01000  ? 56  LYS B CE  1 
ATOM   2073 N  NZ  . LYS B 1 76  ? -61.23704 48.03577 -30.26908 1.000 61.26000  ? 56  LYS B NZ  1 
ATOM   2074 N  N   . TYR B 1 77  ? -60.88791 41.43568 -27.37206 1.000 58.24000  ? 57  TYR B N   1 
ATOM   2075 C  CA  . TYR B 1 77  ? -60.44019 40.14284 -27.88811 1.000 60.02000  ? 57  TYR B CA  1 
ATOM   2076 C  C   . TYR B 1 77  ? -61.42218 39.04806 -27.50331 1.000 55.25000  ? 57  TYR B C   1 
ATOM   2077 O  O   . TYR B 1 77  ? -61.82945 38.23461 -28.34008 1.000 60.90000  ? 57  TYR B O   1 
ATOM   2078 C  CB  . TYR B 1 77  ? -59.04102 39.77662 -27.38295 1.000 50.18000  ? 57  TYR B CB  1 
ATOM   2079 C  CG  . TYR B 1 77  ? -57.94623 40.81224 -27.52246 1.000 55.11000  ? 57  TYR B CG  1 
ATOM   2080 C  CD1 . TYR B 1 77  ? -57.97776 41.80522 -28.50248 1.000 57.38000  ? 57  TYR B CD1 1 
ATOM   2081 C  CD2 . TYR B 1 77  ? -56.85139 40.78323 -26.66528 1.000 57.13000  ? 57  TYR B CD2 1 
ATOM   2082 C  CE1 . TYR B 1 77  ? -56.94320 42.73869 -28.60349 1.000 53.61000  ? 57  TYR B CE1 1 
ATOM   2083 C  CE2 . TYR B 1 77  ? -55.83261 41.70380 -26.75590 1.000 52.27000  ? 57  TYR B CE2 1 
ATOM   2084 C  CZ  . TYR B 1 77  ? -55.88371 42.67922 -27.71191 1.000 57.55000  ? 57  TYR B CZ  1 
ATOM   2085 O  OH  . TYR B 1 77  ? -54.84065 43.57121 -27.75620 1.000 64.48000  ? 57  TYR B OH  1 
ATOM   2086 N  N   . LEU B 1 78  ? -61.84591 39.04421 -26.23995 1.000 58.21000  ? 58  LEU B N   1 
ATOM   2087 C  CA  . LEU B 1 78  ? -62.72947 37.99683 -25.75475 1.000 58.03000  ? 58  LEU B CA  1 
ATOM   2088 C  C   . LEU B 1 78  ? -64.15264 38.18546 -26.26055 1.000 55.34000  ? 58  LEU B C   1 
ATOM   2089 O  O   . LEU B 1 78  ? -64.82739 37.20572 -26.58979 1.000 54.80000  ? 58  LEU B O   1 
ATOM   2090 C  CB  . LEU B 1 78  ? -62.68825 37.95794 -24.21767 1.000 57.00000  ? 58  LEU B CB  1 
ATOM   2091 C  CG  . LEU B 1 78  ? -61.31482 37.68958 -23.58781 1.000 62.35000  ? 58  LEU B CG  1 
ATOM   2092 C  CD1 . LEU B 1 78  ? -61.09737 38.45248 -22.28920 1.000 53.29000  ? 58  LEU B CD1 1 
ATOM   2093 C  CD2 . LEU B 1 78  ? -61.10921 36.19654 -23.37254 1.000 56.76000  ? 58  LEU B CD2 1 
ATOM   2094 N  N   . SER B 1 79  ? -64.63269 39.43160 -26.30039 1.000 57.49000  ? 59  SER B N   1 
ATOM   2095 C  CA  . SER B 1 79  ? -65.92955 39.71709 -26.91020 1.000 54.84000  ? 59  SER B CA  1 
ATOM   2096 C  C   . SER B 1 79  ? -65.96688 39.24467 -28.35676 1.000 55.08000  ? 59  SER B C   1 
ATOM   2097 O  O   . SER B 1 79  ? -66.97202 38.68993 -28.81068 1.000 60.45000  ? 59  SER B O   1 
ATOM   2098 C  CB  . SER B 1 79  ? -66.22355 41.21785 -26.83584 1.000 45.26000  ? 59  SER B CB  1 
ATOM   2099 N  N   . ALA B 1 80  ? -64.87057 39.45481 -29.08841 1.000 52.31000  ? 60  ALA B N   1 
ATOM   2100 C  CA  . ALA B 1 80  ? -64.82991 39.11982 -30.51124 1.000 59.10000  ? 60  ALA B CA  1 
ATOM   2101 C  C   . ALA B 1 80  ? -65.10487 37.64298 -30.74171 1.000 60.63000  ? 60  ALA B C   1 
ATOM   2102 O  O   . ALA B 1 80  ? -65.89059 37.27687 -31.63255 1.000 57.56000  ? 60  ALA B O   1 
ATOM   2103 C  CB  . ALA B 1 80  ? -63.46919 39.49264 -31.11415 1.000 52.12000  ? 60  ALA B CB  1 
ATOM   2104 N  N   . ILE B 1 81  ? -64.45053 36.78081 -29.95574 1.000 59.16000  ? 61  ILE B N   1 
ATOM   2105 C  CA  . ILE B 1 81  ? -64.61993 35.34533 -30.11188 1.000 53.56000  ? 61  ILE B CA  1 
ATOM   2106 C  C   . ILE B 1 81  ? -66.00933 34.94291 -29.66677 1.000 55.60000  ? 61  ILE B C   1 
ATOM   2107 O  O   . ILE B 1 81  ? -66.69397 34.17031 -30.33303 1.000 57.58000  ? 61  ILE B O   1 
ATOM   2108 C  CB  . ILE B 1 81  ? -63.52686 34.60470 -29.32759 1.000 62.22000  ? 61  ILE B CB  1 
ATOM   2109 C  CG1 . ILE B 1 81  ? -62.15451 35.18763 -29.64293 1.000 56.95000  ? 61  ILE B CG1 1 
ATOM   2110 C  CG2 . ILE B 1 81  ? -63.52017 33.14581 -29.66517 1.000 56.32000  ? 61  ILE B CG2 1 
ATOM   2111 C  CD1 . ILE B 1 81  ? -61.02700 34.39782 -29.05526 1.000 55.05000  ? 61  ILE B CD1 1 
ATOM   2112 N  N   . HIS B 1 82  ? -66.45381 35.48097 -28.54602 1.000 56.72000  ? 62  HIS B N   1 
ATOM   2113 C  CA  . HIS B 1 82  ? -67.76138 35.12291 -28.01795 1.000 59.26000  ? 62  HIS B CA  1 
ATOM   2114 C  C   . HIS B 1 82  ? -68.84153 35.45905 -29.02995 1.000 57.40000  ? 62  HIS B C   1 
ATOM   2115 O  O   . HIS B 1 82  ? -69.74299 34.65285 -29.29048 1.000 56.87000  ? 62  HIS B O   1 
ATOM   2116 C  CB  . HIS B 1 82  ? -67.95902 35.85417 -26.68139 1.000 50.31000  ? 62  HIS B CB  1 
ATOM   2117 C  CG  . HIS B 1 82  ? -69.30466 35.69444 -26.06989 1.000 55.34000  ? 62  HIS B CG  1 
ATOM   2118 N  ND1 . HIS B 1 82  ? -70.41549 36.34636 -26.54437 1.000 55.02000  ? 62  HIS B ND1 1 
ATOM   2119 C  CD2 . HIS B 1 82  ? -69.70986 35.00251 -24.97889 1.000 51.24000  ? 62  HIS B CD2 1 
ATOM   2120 C  CE1 . HIS B 1 82  ? -71.46103 36.04308 -25.79288 1.000 56.15000  ? 62  HIS B CE1 1 
ATOM   2121 N  NE2 . HIS B 1 82  ? -71.05721 35.23090 -24.83254 1.000 54.93000  ? 62  HIS B NE2 1 
ATOM   2122 N  N   . SER B 1 83  ? -68.73571 36.63766 -29.64436 1.000 53.15000  ? 63  SER B N   1 
ATOM   2123 C  CA  . SER B 1 83  ? -69.75348 37.09596 -30.59200 1.000 62.60000  ? 63  SER B CA  1 
ATOM   2124 C  C   . SER B 1 83  ? -69.96465 36.14069 -31.76148 1.000 58.54000  ? 63  SER B C   1 
ATOM   2125 O  O   . SER B 1 83  ? -71.05012 36.12307 -32.34830 1.000 56.18000  ? 63  SER B O   1 
ATOM   2126 C  CB  . SER B 1 83  ? -69.38629 38.46995 -31.14250 1.000 56.53000  ? 63  SER B CB  1 
ATOM   2127 O  OG  . SER B 1 83  ? -68.23912 38.36005 -31.94926 1.000 56.54000  ? 63  SER B OG  1 
ATOM   2128 N  N   . ARG B 1 84  ? -68.95688 35.33306 -32.10428 1.000 59.79000  ? 64  ARG B N   1 
ATOM   2129 C  CA  . ARG B 1 84  ? -69.03390 34.39966 -33.22371 1.000 61.89000  ? 64  ARG B CA  1 
ATOM   2130 C  C   . ARG B 1 84  ? -69.22692 32.94926 -32.79012 1.000 62.94000  ? 64  ARG B C   1 
ATOM   2131 O  O   . ARG B 1 84  ? -69.15540 32.04573 -33.62897 1.000 55.00000  ? 64  ARG B O   1 
ATOM   2132 C  CB  . ARG B 1 84  ? -67.77110 34.50582 -34.08624 1.000 64.93000  ? 64  ARG B CB  1 
ATOM   2133 C  CG  . ARG B 1 84  ? -67.61255 35.83794 -34.80415 1.000 61.11000  ? 64  ARG B CG  1 
ATOM   2134 C  CD  . ARG B 1 84  ? -66.14798 36.15622 -35.04455 1.000 61.90000  ? 64  ARG B CD  1 
ATOM   2135 N  NE  . ARG B 1 84  ? -66.03265 37.35600 -35.85981 1.000 61.48000  ? 64  ARG B NE  1 
ATOM   2136 C  CZ  . ARG B 1 84  ? -65.77114 38.56542 -35.37773 1.000 64.90000  ? 64  ARG B CZ  1 
ATOM   2137 N  NH1 . ARG B 1 84  ? -65.56085 38.76744 -34.07942 1.000 69.59000  ? 64  ARG B NH1 1 
ATOM   2138 N  NH2 . ARG B 1 84  ? -65.71508 39.59782 -36.21516 1.000 61.77000  ? 64  ARG B NH2 1 
ATOM   2139 N  N   . CYS B 1 85  ? -69.46363 32.69868 -31.51049 1.000 62.40000  ? 65  CYS B N   1 
ATOM   2140 C  CA  . CYS B 1 85  ? -69.49609 31.34044 -30.99693 1.000 51.14000  ? 65  CYS B CA  1 
ATOM   2141 C  C   . CYS B 1 85  ? -70.92231 30.85685 -30.77750 1.000 59.63000  ? 65  CYS B C   1 
ATOM   2142 O  O   . CYS B 1 85  ? -71.76011 31.59080 -30.24168 1.000 63.40000  ? 65  CYS B O   1 
ATOM   2143 C  CB  . CYS B 1 85  ? -68.71942 31.25097 -29.68984 1.000 63.35000  ? 65  CYS B CB  1 
ATOM   2144 S  SG  . CYS B 1 85  ? -68.40947 29.56456 -29.23234 1.000 63.98000  ? 65  CYS B SG  1 
ATOM   2145 N  N   . ASP B 1 86  ? -71.18941 29.61246 -31.18671 1.000 60.07000  ? 66  ASP B N   1 
ATOM   2146 C  CA  . ASP B 1 86  ? -72.45746 28.95249 -30.89653 1.000 57.02000  ? 66  ASP B CA  1 
ATOM   2147 C  C   . ASP B 1 86  ? -72.32514 27.78950 -29.92050 1.000 57.72000  ? 66  ASP B C   1 
ATOM   2148 O  O   . ASP B 1 86  ? -73.34208 27.18179 -29.57132 1.000 58.40000  ? 66  ASP B O   1 
ATOM   2149 C  CB  . ASP B 1 86  ? -73.11974 28.44236 -32.17488 1.000 62.45000  ? 66  ASP B CB  1 
ATOM   2150 C  CG  . ASP B 1 86  ? -73.49641 29.55177 -33.12758 1.000 66.14000  ? 66  ASP B CG  1 
ATOM   2151 O  OD1 . ASP B 1 86  ? -73.87612 30.64350 -32.66463 1.000 67.44000  ? 66  ASP B OD1 1 
ATOM   2152 O  OD2 . ASP B 1 86  ? -73.43128 29.31356 -34.34458 1.000 63.02000  ? 66  ASP B OD2 1 
ATOM   2153 N  N   . ASP B 1 87  ? -71.11149 27.44166 -29.49669 1.000 54.17000  ? 67  ASP B N   1 
ATOM   2154 C  CA  . ASP B 1 87  ? -70.90862 26.49779 -28.38678 1.000 61.80000  ? 67  ASP B CA  1 
ATOM   2155 C  C   . ASP B 1 87  ? -71.27898 27.19337 -27.08008 1.000 55.77000  ? 67  ASP B C   1 
ATOM   2156 O  O   . ASP B 1 87  ? -70.48358 27.94849 -26.52058 1.000 58.93000  ? 67  ASP B O   1 
ATOM   2157 C  CB  . ASP B 1 87  ? -69.45567 26.02732 -28.35127 1.000 58.13000  ? 67  ASP B CB  1 
ATOM   2158 C  CG  . ASP B 1 87  ? -69.23242 24.80474 -27.46080 1.000 66.39000  ? 67  ASP B CG  1 
ATOM   2159 O  OD1 . ASP B 1 87  ? -69.74647 24.73786 -26.30608 1.000 69.79000  ? 67  ASP B OD1 1 
ATOM   2160 O  OD2 . ASP B 1 87  ? -68.49160 23.91334 -27.91740 1.000 68.67000  ? 67  ASP B OD2 1 
ATOM   2161 N  N   . LEU B 1 88  ? -72.48756 26.93670 -26.58477 1.000 59.13000  ? 68  LEU B N   1 
ATOM   2162 C  CA  . LEU B 1 88  ? -72.96301 27.62800 -25.39350 1.000 54.85000  ? 68  LEU B CA  1 
ATOM   2163 C  C   . LEU B 1 88  ? -71.97865 27.50124 -24.22679 1.000 66.00000  ? 68  LEU B C   1 
ATOM   2164 O  O   . LEU B 1 88  ? -71.66107 28.49500 -23.56187 1.000 61.82000  ? 68  LEU B O   1 
ATOM   2165 C  CB  . LEU B 1 88  ? -74.33421 27.08238 -25.00289 1.000 57.25000  ? 68  LEU B CB  1 
ATOM   2166 C  CG  . LEU B 1 88  ? -75.52514 27.40050 -25.90695 1.000 58.24000  ? 68  LEU B CG  1 
ATOM   2167 C  CD1 . LEU B 1 88  ? -76.78479 26.85469 -25.27041 1.000 53.19000  ? 68  LEU B CD1 1 
ATOM   2168 C  CD2 . LEU B 1 88  ? -75.67698 28.89940 -26.15386 1.000 56.02000  ? 68  LEU B CD2 1 
ATOM   2169 N  N   . GLU B 1 89  ? -71.46103 26.29042 -23.98697 1.000 66.15000  ? 69  GLU B N   1 
ATOM   2170 C  CA  . GLU B 1 89  ? -70.55223 26.07692 -22.86587 1.000 59.87000  ? 69  GLU B CA  1 
ATOM   2171 C  C   . GLU B 1 89  ? -69.24592 26.81520 -23.06635 1.000 62.51000  ? 69  GLU B C   1 
ATOM   2172 O  O   . GLU B 1 89  ? -68.61460 27.23478 -22.08792 1.000 65.84000  ? 69  GLU B O   1 
ATOM   2173 C  CB  . GLU B 1 89  ? -70.28787 24.57854 -22.65084 1.000 62.69000  ? 69  GLU B CB  1 
ATOM   2174 C  CG  . GLU B 1 89  ? -71.52372 23.78085 -22.21920 1.000 64.95000  ? 69  GLU B CG  1 
ATOM   2175 C  CD  . GLU B 1 89  ? -72.23636 24.41584 -21.00803 1.000 78.81000  ? 69  GLU B CD  1 
ATOM   2176 O  OE1 . GLU B 1 89  ? -71.53412 24.84374 -20.05749 1.000 81.49000  ? 69  GLU B OE1 1 
ATOM   2177 O  OE2 . GLU B 1 89  ? -73.49229 24.50241 -21.01215 1.000 79.02000  ? 69  GLU B OE2 1 
ATOM   2178 N  N   . ALA B 1 90  ? -68.82546 26.98591 -24.31391 1.000 57.65000  ? 70  ALA B N   1 
ATOM   2179 C  CA  . ALA B 1 90  ? -67.61514 27.75437 -24.56840 1.000 61.55000  ? 70  ALA B CA  1 
ATOM   2180 C  C   . ALA B 1 90  ? -67.80916 29.21165 -24.17910 1.000 56.05000  ? 70  ALA B C   1 
ATOM   2181 O  O   . ALA B 1 90  ? -66.91252 29.83018 -23.60063 1.000 59.62000  ? 70  ALA B O   1 
ATOM   2182 C  CB  . ALA B 1 90  ? -67.20362 27.62089 -26.03935 1.000 53.33000  ? 70  ALA B CB  1 
ATOM   2183 N  N   . ARG B 1 91  ? -68.97700 29.77635 -24.48259 1.000 60.09000  ? 71  ARG B N   1 
ATOM   2184 C  CA  . ARG B 1 91  ? -69.18407 31.19741 -24.22886 1.000 60.13000  ? 71  ARG B CA  1 
ATOM   2185 C  C   . ARG B 1 91  ? -69.12633 31.49996 -22.73103 1.000 62.26000  ? 71  ARG B C   1 
ATOM   2186 O  O   . ARG B 1 91  ? -68.54127 32.51124 -22.31999 1.000 59.25000  ? 71  ARG B O   1 
ATOM   2187 C  CB  . ARG B 1 91  ? -70.50538 31.65775 -24.85457 1.000 54.10000  ? 71  ARG B CB  1 
ATOM   2188 C  CG  . ARG B 1 91  ? -70.49632 31.62317 -26.39146 1.000 60.29000  ? 71  ARG B CG  1 
ATOM   2189 C  CD  . ARG B 1 91  ? -71.42060 32.65190 -27.06718 1.000 60.08000  ? 71  ARG B CD  1 
ATOM   2190 N  NE  . ARG B 1 91  ? -72.74747 32.72324 -26.46556 1.000 55.46000  ? 71  ARG B NE  1 
ATOM   2191 C  CZ  . ARG B 1 91  ? -73.86775 32.29037 -27.02775 1.000 52.33000  ? 71  ARG B CZ  1 
ATOM   2192 N  NH1 . ARG B 1 91  ? -73.87077 31.74014 -28.23133 1.000 62.09000  ? 71  ARG B NH1 1 
ATOM   2193 N  NH2 . ARG B 1 91  ? -75.01126 32.40323 -26.36007 1.000 52.90000  ? 71  ARG B NH2 1 
ATOM   2194 N  N   . LYS B 1 92  ? -69.69312 30.61074 -21.89832 1.000 58.44000  ? 72  LYS B N   1 
ATOM   2195 C  CA  . LYS B 1 92  ? -69.58929 30.76740 -20.45012 1.000 59.54000  ? 72  LYS B CA  1 
ATOM   2196 C  C   . LYS B 1 92  ? -68.13932 30.91137 -20.02019 1.000 57.13000  ? 72  LYS B C   1 
ATOM   2197 O  O   . LYS B 1 92  ? -67.80065 31.80776 -19.23986 1.000 61.91000  ? 72  LYS B O   1 
ATOM   2198 C  CB  . LYS B 1 92  ? -70.24133 29.58849 -19.73011 1.000 66.29000  ? 72  LYS B CB  1 
ATOM   2199 C  CG  . LYS B 1 92  ? -71.74432 29.42394 -19.95987 0.954 69.12000  ? 72  LYS B CG  1 
ATOM   2200 C  CD  . LYS B 1 92  ? -72.46624 29.14156 -18.62127 1.000 81.07000  ? 72  LYS B CD  1 
ATOM   2201 C  CE  . LYS B 1 92  ? -73.74975 28.33197 -18.77783 1.000 79.90000  ? 72  LYS B CE  1 
ATOM   2202 N  NZ  . LYS B 1 92  ? -73.52723 26.96456 -19.34942 1.000 83.49000  ? 72  LYS B NZ  1 
ATOM   2203 N  N   . LEU B 1 93  ? -67.25429 30.07323 -20.54470 1.000 54.37000  ? 73  LEU B N   1 
ATOM   2204 C  CA  . LEU B 1 93  ? -65.86251 30.21233 -20.14623 1.000 52.49000  ? 73  LEU B CA  1 
ATOM   2205 C  C   . LEU B 1 93  ? -65.25541 31.50662 -20.68423 1.000 54.39000  ? 73  LEU B C   1 
ATOM   2206 O  O   . LEU B 1 93  ? -64.44853 32.15044 -20.00216 1.000 58.97000  ? 73  LEU B O   1 
ATOM   2207 C  CB  . LEU B 1 93  ? -65.06020 28.99132 -20.58337 1.000 51.22000  ? 73  LEU B CB  1 
ATOM   2208 C  CG  . LEU B 1 93  ? -65.32860 27.74216 -19.72429 1.000 62.98000  ? 73  LEU B CG  1 
ATOM   2209 C  CD1 . LEU B 1 93  ? -65.13577 26.46211 -20.51876 1.000 53.54000  ? 73  LEU B CD1 1 
ATOM   2210 C  CD2 . LEU B 1 93  ? -64.46113 27.71267 -18.45388 1.000 54.90000  ? 73  LEU B CD2 1 
ATOM   2211 N  N   . LEU B 1 94  ? -65.65127 31.93416 -21.88831 1.000 57.61000  ? 74  LEU B N   1 
ATOM   2212 C  CA  . LEU B 1 94  ? -65.14033 33.20730 -22.39931 1.000 58.05000  ? 74  LEU B CA  1 
ATOM   2213 C  C   . LEU B 1 94  ? -65.70216 34.38078 -21.60284 1.000 54.46000  ? 74  LEU B C   1 
ATOM   2214 O  O   . LEU B 1 94  ? -64.98194 35.32738 -21.29278 1.000 50.28000  ? 74  LEU B O   1 
ATOM   2215 C  CB  . LEU B 1 94  ? -65.47010 33.36213 -23.89599 1.000 60.77000  ? 74  LEU B CB  1 
ATOM   2216 C  CG  . LEU B 1 94  ? -64.78596 32.46562 -24.93251 1.000 51.56000  ? 74  LEU B CG  1 
ATOM   2217 C  CD1 . LEU B 1 94  ? -65.67079 32.27610 -26.10549 1.000 57.25000  ? 74  LEU B CD1 1 
ATOM   2218 C  CD2 . LEU B 1 94  ? -63.44303 33.03880 -25.36238 1.000 54.57000  ? 74  LEU B CD2 1 
ATOM   2219 N  N   . LEU B 1 95  ? -66.99246 34.33472 -21.28042 1.000 57.84000  ? 75  LEU B N   1 
ATOM   2220 C  CA  . LEU B 1 95  ? -67.58370 35.34053 -20.41193 1.000 58.79000  ? 75  LEU B CA  1 
ATOM   2221 C  C   . LEU B 1 95  ? -66.91318 35.36398 -19.04376 1.000 58.58000  ? 75  LEU B C   1 
ATOM   2222 O  O   . LEU B 1 95  ? -66.76636 36.44514 -18.46206 1.000 57.21000  ? 75  LEU B O   1 
ATOM   2223 C  CB  . LEU B 1 95  ? -69.08147 35.08230 -20.27764 1.000 53.91000  ? 75  LEU B CB  1 
ATOM   2224 C  CG  . LEU B 1 95  ? -69.92151 36.06970 -19.47465 1.000 56.88000  ? 75  LEU B CG  1 
ATOM   2225 C  CD1 . LEU B 1 95  ? -69.71869 37.47213 -20.01904 1.000 49.23000  ? 75  LEU B CD1 1 
ATOM   2226 C  CD2 . LEU B 1 95  ? -71.38021 35.65575 -19.53214 1.000 54.67000  ? 75  LEU B CD2 1 
ATOM   2227 N  N   . ASP B 1 96  ? -66.47841 34.20085 -18.52810 1.000 54.83000  ? 76  ASP B N   1 
ATOM   2228 C  CA  . ASP B 1 96  ? -65.78357 34.17958 -17.23914 1.000 58.54000  ? 76  ASP B CA  1 
ATOM   2229 C  C   . ASP B 1 96  ? -64.50970 35.00529 -17.28667 1.000 60.86000  ? 76  ASP B C   1 
ATOM   2230 O  O   . ASP B 1 96  ? -64.24068 35.79664 -16.37445 1.000 55.05000  ? 76  ASP B O   1 
ATOM   2231 C  CB  . ASP B 1 96  ? -65.46359 32.74288 -16.80885 1.000 60.00000  ? 76  ASP B CB  1 
ATOM   2232 C  CG  . ASP B 1 96  ? -66.62844 32.07061 -16.10561 1.000 64.66000  ? 76  ASP B CG  1 
ATOM   2233 O  OD1 . ASP B 1 96  ? -67.46065 32.80256 -15.51093 1.000 76.55000  ? 76  ASP B OD1 1 
ATOM   2234 O  OD2 . ASP B 1 96  ? -66.73450 30.81941 -16.17190 1.000 69.37000  ? 76  ASP B OD2 1 
ATOM   2235 N  N   . ASN B 1 97  ? -63.70845 34.83248 -18.34767 1.000 61.46000  ? 77  ASN B N   1 
ATOM   2236 C  CA  . ASN B 1 97  ? -62.47237 35.60119 -18.47215 1.000 58.51000  ? 77  ASN B CA  1 
ATOM   2237 C  C   . ASN B 1 97  ? -62.77851 37.07648 -18.61842 1.000 55.01000  ? 77  ASN B C   1 
ATOM   2238 O  O   . ASN B 1 97  ? -62.15356 37.91486 -17.97248 1.000 54.96000  ? 77  ASN B O   1 
ATOM   2239 C  CB  . ASN B 1 97  ? -61.63769 35.11004 -19.66328 1.000 56.48000  ? 77  ASN B CB  1 
ATOM   2240 C  CG  . ASN B 1 97  ? -60.18363 35.65478 -19.65683 1.000 64.14000  ? 77  ASN B CG  1 
ATOM   2241 O  OD1 . ASN B 1 97  ? -59.92093 36.82660 -19.38858 1.000 61.54000  ? 77  ASN B OD1 1 
ATOM   2242 N  ND2 . ASN B 1 97  ? -59.24395 34.78554 -19.98254 1.000 63.20000  ? 77  ASN B ND2 1 
ATOM   2243 N  N   . LEU B 1 98  ? -63.72883 37.41136 -19.47900 1.000 60.79000  ? 78  LEU B N   1 
ATOM   2244 C  CA  . LEU B 1 98  ? -64.00578 38.81692 -19.73549 1.000 58.88000  ? 78  LEU B CA  1 
ATOM   2245 C  C   . LEU B 1 98  ? -64.55912 39.49097 -18.48774 1.000 64.10000  ? 78  LEU B C   1 
ATOM   2246 O  O   . LEU B 1 98  ? -64.25712 40.66010 -18.22683 1.000 58.20000  ? 78  LEU B O   1 
ATOM   2247 C  CB  . LEU B 1 98  ? -64.95974 38.95190 -20.92000 1.000 55.42000  ? 78  LEU B CB  1 
ATOM   2248 C  CG  . LEU B 1 98  ? -65.81621 40.20254 -21.08159 1.000 57.95000  ? 78  LEU B CG  1 
ATOM   2249 C  CD1 . LEU B 1 98  ? -64.96469 41.37834 -21.46375 1.000 54.69000  ? 78  LEU B CD1 1 
ATOM   2250 C  CD2 . LEU B 1 98  ? -66.90121 39.94849 -22.12998 1.000 50.16000  ? 78  LEU B CD2 1 
ATOM   2251 N  N   . MET B 1 99  ? -65.33989 38.76385 -17.69301 1.000 54.81000  ? 79  MET B N   1 
ATOM   2252 C  CA  . MET B 1 99  ? -65.72137 39.28520 -16.38539 1.000 57.24000  ? 79  MET B CA  1 
ATOM   2253 C  C   . MET B 1 99  ? -64.49787 39.58711 -15.53238 1.000 59.12000  ? 79  MET B C   1 
ATOM   2254 O  O   . MET B 1 99  ? -64.42350 40.64849 -14.91033 1.000 54.57000  ? 79  MET B O   1 
ATOM   2255 C  CB  . MET B 1 99  ? -66.63803 38.30011 -15.68014 1.000 62.27000  ? 79  MET B CB  1 
ATOM   2256 C  CG  . MET B 1 99  ? -68.05704 38.55444 -16.03080 1.000 59.85000  ? 79  MET B CG  1 
ATOM   2257 S  SD  . MET B 1 99  ? -69.16400 37.21369 -15.65369 1.000 60.11000  ? 79  MET B SD  1 
ATOM   2258 C  CE  . MET B 1 99  ? -69.68910 37.69228 -14.00605 1.000 72.01000  ? 79  MET B CE  1 
ATOM   2259 N  N   . ASP B 1 100 ? -63.52160 38.67479 -15.49921 1.000 60.42000  ? 80  ASP B N   1 
ATOM   2260 C  CA  . ASP B 1 100 ? -62.32370 38.92167 -14.69926 1.000 61.28000  ? 80  ASP B CA  1 
ATOM   2261 C  C   . ASP B 1 100 ? -61.61490 40.18178 -15.16775 1.000 62.39000  ? 80  ASP B C   1 
ATOM   2262 O  O   . ASP B 1 100 ? -61.08821 40.94927 -14.35488 1.000 65.02000  ? 80  ASP B O   1 
ATOM   2263 C  CB  . ASP B 1 100 ? -61.35095 37.73203 -14.75902 1.000 65.04000  ? 80  ASP B CB  1 
ATOM   2264 C  CG  . ASP B 1 100 ? -61.84287 36.50495 -13.98986 1.000 68.48000  ? 80  ASP B CG  1 
ATOM   2265 O  OD1 . ASP B 1 100 ? -62.73168 36.64324 -13.11598 1.000 70.71000  ? 80  ASP B OD1 1 
ATOM   2266 O  OD2 . ASP B 1 100 ? -61.32915 35.39840 -14.27384 1.000 66.64000  ? 80  ASP B OD2 1 
ATOM   2267 N  N   . GLU B 1 101 ? -61.59684 40.41544 -16.47859 1.000 64.64000  ? 81  GLU B N   1 
ATOM   2268 C  CA  . GLU B 1 101 ? -60.84435 41.53441 -17.02148 1.000 62.35000  ? 81  GLU B CA  1 
ATOM   2269 C  C   . GLU B 1 101 ? -61.53148 42.86674 -16.75954 1.000 66.33000  ? 81  GLU B C   1 
ATOM   2270 O  O   . GLU B 1 101 ? -60.86729 43.85195 -16.42067 1.000 63.33000  ? 81  GLU B O   1 
ATOM   2271 C  CB  . GLU B 1 101 ? -60.62921 41.33989 -18.52518 1.000 68.18000  ? 81  GLU B CB  1 
ATOM   2272 C  CG  . GLU B 1 101 ? -59.59337 40.29124 -18.86196 1.000 67.92000  ? 81  GLU B CG  1 
ATOM   2273 C  CD  . GLU B 1 101 ? -58.18315 40.80289 -18.66527 1.000 71.48000  ? 81  GLU B CD  1 
ATOM   2274 O  OE1 . GLU B 1 101 ? -57.90842 41.96452 -19.02670 1.000 66.01000  ? 81  GLU B OE1 1 
ATOM   2275 O  OE2 . GLU B 1 101 ? -57.35271 40.04777 -18.12998 1.000 78.09000  ? 81  GLU B OE2 1 
ATOM   2276 N  N   . GLU B 1 102 ? -62.84472 42.93100 -16.91797 1.000 64.71000  ? 82  GLU B N   1 
ATOM   2277 C  CA  . GLU B 1 102 ? -63.49508 44.22648 -17.02322 1.000 66.27000  ? 82  GLU B CA  1 
ATOM   2278 C  C   . GLU B 1 102 ? -64.46585 44.53835 -15.89777 1.000 62.16000  ? 82  GLU B C   1 
ATOM   2279 O  O   . GLU B 1 102 ? -64.58185 45.69867 -15.51082 1.000 61.53000  ? 82  GLU B O   1 
ATOM   2280 C  CB  . GLU B 1 102 ? -64.23437 44.34766 -18.36017 1.000 56.94000  ? 82  GLU B CB  1 
ATOM   2281 C  CG  . GLU B 1 102 ? -64.36623 45.78839 -18.85947 1.000 68.81000  ? 82  GLU B CG  1 
ATOM   2282 C  CD  . GLU B 1 102 ? -64.68138 45.90040 -20.37528 1.000 65.20000  ? 82  GLU B CD  1 
ATOM   2283 O  OE1 . GLU B 1 102 ? -65.56533 45.17594 -20.88276 1.000 62.38000  ? 82  GLU B OE1 1 
ATOM   2284 O  OE2 . GLU B 1 102 ? -64.04729 46.73380 -21.04709 1.000 61.37000  ? 82  GLU B OE2 1 
ATOM   2285 N  N   . ASN B 1 103 ? -65.17478 43.54899 -15.37489 1.000 61.19000  ? 83  ASN B N   1 
ATOM   2286 C  CA  . ASN B 1 103 ? -66.27632 43.82739 -14.46594 1.000 69.62000  ? 83  ASN B CA  1 
ATOM   2287 C  C   . ASN B 1 103 ? -65.80830 44.39368 -13.12893 1.000 67.49000  ? 83  ASN B C   1 
ATOM   2288 O  O   . ASN B 1 103 ? -64.73459 44.05662 -12.61954 1.000 71.01000  ? 83  ASN B O   1 
ATOM   2289 C  CB  . ASN B 1 103 ? -67.07824 42.57381 -14.18941 1.000 63.52000  ? 83  ASN B CB  1 
ATOM   2290 C  CG  . ASN B 1 103 ? -68.32305 42.86305 -13.38066 1.000 72.92000  ? 83  ASN B CG  1 
ATOM   2291 O  OD1 . ASN B 1 103 ? -68.63239 42.15807 -12.43094 1.000 70.54000  ? 83  ASN B OD1 1 
ATOM   2292 N  ND2 . ASN B 1 103 ? -69.04129 43.91871 -13.75140 1.000 71.70000  ? 83  ASN B ND2 1 
ATOM   2293 N  N   . GLY B 1 104 ? -66.65603 45.24573 -12.55253 1.000 69.82000  ? 84  GLY B N   1 
ATOM   2294 C  CA  . GLY B 1 104 ? -66.43751 45.79854 -11.23584 1.000 69.59000  ? 84  GLY B CA  1 
ATOM   2295 C  C   . GLY B 1 104 ? -65.35102 46.86005 -11.18150 1.000 76.32000  ? 84  GLY B C   1 
ATOM   2296 O  O   . GLY B 1 104 ? -64.88499 47.40507 -12.19571 1.000 73.43000  ? 84  GLY B O   1 
ATOM   2297 N  N   . TYR B 1 105 ? -64.94976 47.15701 -9.93634  1.000 76.32000  ? 85  TYR B N   1 
ATOM   2298 C  CA  . TYR B 1 105 ? -63.92170 48.13623 -9.62584  1.000 76.16000  ? 85  TYR B CA  1 
ATOM   2299 C  C   . TYR B 1 105 ? -63.06412 47.54841 -8.50811  1.000 71.92000  ? 85  TYR B C   1 
ATOM   2300 O  O   . TYR B 1 105 ? -63.61091 46.99663 -7.54159  1.000 75.71000  ? 85  TYR B O   1 
ATOM   2301 C  CB  . TYR B 1 105 ? -64.51334 49.48403 -9.19968  1.000 76.34000  ? 85  TYR B CB  1 
ATOM   2302 C  CG  . TYR B 1 105 ? -63.48754 50.58260 -9.04069  1.000 79.98000  ? 85  TYR B CG  1 
ATOM   2303 C  CD1 . TYR B 1 105 ? -62.70225 50.66901 -7.88980  1.000 78.34000  ? 85  TYR B CD1 1 
ATOM   2304 C  CD2 . TYR B 1 105 ? -63.30813 51.53621 -10.02827 1.000 83.76000  ? 85  TYR B CD2 1 
ATOM   2305 C  CE1 . TYR B 1 105 ? -61.75370 51.66830 -7.73918  1.000 86.85000  ? 85  TYR B CE1 1 
ATOM   2306 C  CE2 . TYR B 1 105 ? -62.36723 52.54301 -9.88828  1.000 83.00000  ? 85  TYR B CE2 1 
ATOM   2307 C  CZ  . TYR B 1 105 ? -61.58995 52.60615 -8.74440  1.000 89.21000  ? 85  TYR B CZ  1 
ATOM   2308 O  OH  . TYR B 1 105 ? -60.65302 53.60956 -8.61091  1.000 98.70000  ? 85  TYR B OH  1 
ATOM   2309 N  N   . PRO B 1 106 ? -61.73636 47.60148 -8.63191  1.000 73.37000  ? 86  PRO B N   1 
ATOM   2310 C  CA  . PRO B 1 106 ? -60.98623 48.03770 -9.81205  1.000 76.36000  ? 86  PRO B CA  1 
ATOM   2311 C  C   . PRO B 1 106 ? -60.88246 46.89054 -10.82266 1.000 72.60000  ? 86  PRO B C   1 
ATOM   2312 O  O   . PRO B 1 106 ? -60.62524 45.75066 -10.41437 1.000 66.86000  ? 86  PRO B O   1 
ATOM   2313 C  CB  . PRO B 1 106 ? -59.63395 48.44833 -9.21905  1.000 70.78000  ? 86  PRO B CB  1 
ATOM   2314 C  CG  . PRO B 1 106 ? -59.46789 47.55875 -7.99256  1.000 73.39000  ? 86  PRO B CG  1 
ATOM   2315 C  CD  . PRO B 1 106 ? -60.84606 47.11838 -7.56140  1.000 66.49000  ? 86  PRO B CD  1 
ATOM   2316 N  N   . ASN B 1 107 ? -61.11221 47.11806 -12.12045 1.000 69.91000  ? 87  ASN B N   1 
ATOM   2317 C  CA  . ASN B 1 107 ? -60.84986 46.06130 -13.09102 1.000 60.64000  ? 87  ASN B CA  1 
ATOM   2318 C  C   . ASN B 1 107 ? -59.36868 46.07500 -13.43829 1.000 67.43000  ? 87  ASN B C   1 
ATOM   2319 O  O   . ASN B 1 107 ? -58.59573 46.88884 -12.91818 1.000 70.39000  ? 87  ASN B O   1 
ATOM   2320 C  CB  . ASN B 1 107 ? -61.74493 46.19288 -14.32908 1.000 63.94000  ? 87  ASN B CB  1 
ATOM   2321 C  CG  . ASN B 1 107 ? -61.63764 47.53856 -15.01396 1.000 65.85000  ? 87  ASN B CG  1 
ATOM   2322 O  OD1 . ASN B 1 107 ? -60.57721 48.14619 -15.06875 1.000 60.68000  ? 87  ASN B OD1 1 
ATOM   2323 N  ND2 . ASN B 1 107 ? -62.74301 47.99476 -15.56797 1.000 57.44000  ? 87  ASN B ND2 1 
ATOM   2324 N  N   . HIS B 1 108 ? -58.96009 45.15380 -14.31981 1.000 65.73000  ? 88  HIS B N   1 
ATOM   2325 C  CA  . HIS B 1 108 ? -57.55707 45.09120 -14.71044 1.000 64.78000  ? 88  HIS B CA  1 
ATOM   2326 C  C   . HIS B 1 108 ? -57.09179 46.39301 -15.33716 1.000 66.11000  ? 88  HIS B C   1 
ATOM   2327 O  O   . HIS B 1 108 ? -55.90938 46.73172 -15.23814 1.000 70.14000  ? 88  HIS B O   1 
ATOM   2328 C  CB  . HIS B 1 108 ? -57.31194 43.93685 -15.67790 1.000 68.52000  ? 88  HIS B CB  1 
ATOM   2329 C  CG  . HIS B 1 108 ? -57.52516 42.58676 -15.07270 1.000 68.54000  ? 88  HIS B CG  1 
ATOM   2330 N  ND1 . HIS B 1 108 ? -57.26102 41.41775 -15.75191 1.000 74.48000  ? 88  HIS B ND1 1 
ATOM   2331 C  CD2 . HIS B 1 108 ? -57.99385 42.21840 -13.85602 1.000 73.41000  ? 88  HIS B CD2 1 
ATOM   2332 C  CE1 . HIS B 1 108 ? -57.55278 40.38714 -14.97675 1.000 77.64000  ? 88  HIS B CE1 1 
ATOM   2333 N  NE2 . HIS B 1 108 ? -57.99810 40.84510 -13.82103 1.000 70.94000  ? 88  HIS B NE2 1 
ATOM   2334 N  N   . ILE B 1 109 ? -57.98870 47.13037 -15.99921 1.000 65.53000  ? 89  ILE B N   1 
ATOM   2335 C  CA  . ILE B 1 109 ? -57.59822 48.41818 -16.57145 1.000 67.79000  ? 89  ILE B CA  1 
ATOM   2336 C  C   . ILE B 1 109 ? -57.28640 49.41393 -15.46239 1.000 70.26000  ? 89  ILE B C   1 
ATOM   2337 O  O   . ILE B 1 109 ? -56.18482 49.96952 -15.39917 1.000 71.65000  ? 89  ILE B O   1 
ATOM   2338 C  CB  . ILE B 1 109 ? -58.68951 48.95942 -17.50355 1.000 69.04000  ? 89  ILE B CB  1 
ATOM   2339 C  CG1 . ILE B 1 109 ? -59.06103 47.90522 -18.55906 1.000 72.14000  ? 89  ILE B CG1 1 
ATOM   2340 C  CG2 . ILE B 1 109 ? -58.21773 50.26389 -18.08887 1.000 64.68000  ? 89  ILE B CG2 1 
ATOM   2341 C  CD1 . ILE B 1 109 ? -59.94896 48.41558 -19.69639 1.000 59.84000  ? 89  ILE B CD1 1 
ATOM   2342 N  N   . ASP B 1 110 ? -58.26257 49.65389 -14.57429 1.000 67.23000  ? 90  ASP B N   1 
ATOM   2343 C  CA  . ASP B 1 110 ? -58.02347 50.47849 -13.39161 1.000 69.27000  ? 90  ASP B CA  1 
ATOM   2344 C  C   . ASP B 1 110 ? -56.76770 50.03118 -12.65364 1.000 72.76000  ? 90  ASP B C   1 
ATOM   2345 O  O   . ASP B 1 110 ? -56.00752 50.86018 -12.13076 1.000 72.15000  ? 90  ASP B O   1 
ATOM   2346 C  CB  . ASP B 1 110 ? -59.22086 50.42141 -12.43985 1.000 66.86000  ? 90  ASP B CB  1 
ATOM   2347 C  CG  . ASP B 1 110 ? -60.53793 50.77321 -13.10785 1.000 75.22000  ? 90  ASP B CG  1 
ATOM   2348 O  OD1 . ASP B 1 110 ? -60.54103 51.58277 -14.07480 1.000 77.09000  ? 90  ASP B OD1 1 
ATOM   2349 O  OD2 . ASP B 1 110 ? -61.57575 50.22677 -12.65057 1.000 73.83000  ? 90  ASP B OD2 1 
ATOM   2350 N  N   . LEU B 1 111 ? -56.53734 48.71712 -12.59494 1.000 69.66000  ? 91  LEU B N   1 
ATOM   2351 C  CA  . LEU B 1 111 ? -55.32763 48.21946 -11.95738 1.000 68.18000  ? 91  LEU B CA  1 
ATOM   2352 C  C   . LEU B 1 111 ? -54.07985 48.58517 -12.75417 1.000 66.41000  ? 91  LEU B C   1 
ATOM   2353 O  O   . LEU B 1 111 ? -53.00578 48.76871 -12.16872 1.000 64.64000  ? 91  LEU B O   1 
ATOM   2354 C  CB  . LEU B 1 111 ? -55.41695 46.70734 -11.76901 1.000 63.71000  ? 91  LEU B CB  1 
ATOM   2355 C  CG  . LEU B 1 111 ? -56.11692 46.20097 -10.51004 1.000 69.80000  ? 91  LEU B CG  1 
ATOM   2356 C  CD1 . LEU B 1 111 ? -56.06556 44.69846 -10.44044 1.000 63.98000  ? 91  LEU B CD1 1 
ATOM   2357 C  CD2 . LEU B 1 111 ? -55.48669 46.82456 -9.28305  1.000 64.10000  ? 91  LEU B CD2 1 
ATOM   2358 N  N   . TRP B 1 112 ? -54.18281 48.69403 -14.08031 1.000 63.44000  ? 92  TRP B N   1 
ATOM   2359 C  CA  . TRP B 1 112 ? -52.99666 49.08472 -14.83160 1.000 68.72000  ? 92  TRP B CA  1 
ATOM   2360 C  C   . TRP B 1 112 ? -52.71915 50.57394 -14.68351 1.000 65.57000  ? 92  TRP B C   1 
ATOM   2361 O  O   . TRP B 1 112 ? -51.55779 50.98382 -14.56103 1.000 70.13000  ? 92  TRP B O   1 
ATOM   2362 C  CB  . TRP B 1 112 ? -53.13418 48.71696 -16.31337 1.000 69.15000  ? 92  TRP B CB  1 
ATOM   2363 C  CG  . TRP B 1 112 ? -51.85708 48.95782 -17.03999 1.000 65.13000  ? 92  TRP B CG  1 
ATOM   2364 C  CD1 . TRP B 1 112 ? -51.51428 50.07331 -17.73538 1.000 66.38000  ? 92  TRP B CD1 1 
ATOM   2365 C  CD2 . TRP B 1 112 ? -50.72008 48.09174 -17.08753 1.000 62.10000  ? 92  TRP B CD2 1 
ATOM   2366 N  NE1 . TRP B 1 112 ? -50.25038 49.94141 -18.25213 1.000 70.31000  ? 92  TRP B NE1 1 
ATOM   2367 C  CE2 . TRP B 1 112 ? -49.73925 48.73213 -17.86153 1.000 67.09000  ? 92  TRP B CE2 1 
ATOM   2368 C  CE3 . TRP B 1 112 ? -50.44848 46.82342 -16.58048 1.000 58.45000  ? 92  TRP B CE3 1 
ATOM   2369 C  CZ2 . TRP B 1 112 ? -48.50216 48.14954 -18.13136 1.000 64.45000  ? 92  TRP B CZ2 1 
ATOM   2370 C  CZ3 . TRP B 1 112 ? -49.21772 46.24582 -16.85351 1.000 62.45000  ? 92  TRP B CZ3 1 
ATOM   2371 C  CH2 . TRP B 1 112 ? -48.26409 46.90757 -17.61754 1.000 63.91000  ? 92  TRP B CH2 1 
ATOM   2372 N  N   . LYS B 1 113 ? -53.77573 51.38703 -14.69862 1.000 62.93000  ? 93  LYS B N   1 
ATOM   2373 C  CA  . LYS B 1 113 ? -53.62452 52.81976 -14.47738 1.000 69.76000  ? 93  LYS B CA  1 
ATOM   2374 C  C   . LYS B 1 113 ? -52.88111 53.07475 -13.18198 1.000 78.93000  ? 93  LYS B C   1 
ATOM   2375 O  O   . LYS B 1 113 ? -51.86832 53.78344 -13.16802 1.000 77.81000  ? 93  LYS B O   1 
ATOM   2376 C  CB  . LYS B 1 113 ? -54.99323 53.50078 -14.44768 1.000 68.31000  ? 93  LYS B CB  1 
ATOM   2377 C  CG  . LYS B 1 113 ? -55.56397 53.87220 -15.81046 1.000 68.72000  ? 93  LYS B CG  1 
ATOM   2378 C  CD  . LYS B 1 113 ? -57.07933 53.86628 -15.76496 1.000 68.61000  ? 93  LYS B CD  1 
ATOM   2379 C  CE  . LYS B 1 113 ? -57.60469 55.17420 -15.20623 1.000 67.61000  ? 93  LYS B CE  1 
ATOM   2380 N  NZ  . LYS B 1 113 ? -58.97747 55.45415 -15.68505 1.000 82.82000  ? 93  LYS B NZ  1 
ATOM   2381 N  N   . GLN B 1 114 ? -53.37382 52.48489 -12.08358 1.000 68.75000  ? 94  GLN B N   1 
ATOM   2382 C  CA  . GLN B 1 114 ? -52.66793 52.49501 -10.80663 1.000 72.04000  ? 94  GLN B CA  1 
ATOM   2383 C  C   . GLN B 1 114 ? -51.16580 52.32816 -10.99155 1.000 77.32000  ? 94  GLN B C   1 
ATOM   2384 O  O   . GLN B 1 114 ? -50.37075 53.14089 -10.50935 1.000 79.67000  ? 94  GLN B O   1 
ATOM   2385 C  CB  . GLN B 1 114 ? -53.21533 51.38133 -9.89875  1.000 76.38000  ? 94  GLN B CB  1 
ATOM   2386 C  CG  . GLN B 1 114 ? -54.57589 51.67657 -9.27220  1.000 83.40000  ? 94  GLN B CG  1 
ATOM   2387 C  CD  . GLN B 1 114 ? -54.93204 50.73464 -8.12081  1.000 84.61000  ? 94  GLN B CD  1 
ATOM   2388 O  OE1 . GLN B 1 114 ? -54.05807 50.22223 -7.40967  1.000 82.83000  ? 94  GLN B OE1 1 
ATOM   2389 N  NE2 . GLN B 1 114 ? -56.22637 50.50872 -7.93302  1.000 71.05000  ? 94  GLN B NE2 1 
ATOM   2390 N  N   . PHE B 1 115 ? -50.76307 51.28896 -11.71877 1.000 73.76000  ? 95  PHE B N   1 
ATOM   2391 C  CA  . PHE B 1 115 ? -49.34164 50.98749 -11.85742 1.000 74.54000  ? 95  PHE B CA  1 
ATOM   2392 C  C   . PHE B 1 115 ? -48.60527 52.11060 -12.57185 1.000 78.15000  ? 95  PHE B C   1 
ATOM   2393 O  O   . PHE B 1 115 ? -47.56070 52.57525 -12.09816 1.000 72.92000  ? 95  PHE B O   1 
ATOM   2394 C  CB  . PHE B 1 115 ? -49.16798 49.66844 -12.60218 1.000 75.82000  ? 95  PHE B CB  1 
ATOM   2395 C  CG  . PHE B 1 115 ? -47.75858 49.38669 -13.02448 1.000 75.16000  ? 95  PHE B CG  1 
ATOM   2396 C  CD1 . PHE B 1 115 ? -47.46042 49.10838 -14.35764 1.000 74.67000  ? 95  PHE B CD1 1 
ATOM   2397 C  CD2 . PHE B 1 115 ? -46.72949 49.38730 -12.09258 1.000 76.28000  ? 95  PHE B CD2 1 
ATOM   2398 C  CE1 . PHE B 1 115 ? -46.15114 48.83585 -14.75027 1.000 76.70000  ? 95  PHE B CE1 1 
ATOM   2399 C  CE2 . PHE B 1 115 ? -45.42075 49.11302 -12.47261 1.000 72.25000  ? 95  PHE B CE2 1 
ATOM   2400 C  CZ  . PHE B 1 115 ? -45.12972 48.83751 -13.80149 1.000 66.19000  ? 95  PHE B CZ  1 
ATOM   2401 N  N   . VAL B 1 116 ? -49.14450 52.55542 -13.71496 1.000 70.87000  ? 96  VAL B N   1 
ATOM   2402 C  CA  . VAL B 1 116 ? -48.57633 53.68885 -14.44733 1.000 75.89000  ? 96  VAL B CA  1 
ATOM   2403 C  C   . VAL B 1 116 ? -48.34819 54.87159 -13.50917 1.000 80.67000  ? 96  VAL B C   1 
ATOM   2404 O  O   . VAL B 1 116 ? -47.28674 55.50569 -13.53177 1.000 82.69000  ? 96  VAL B O   1 
ATOM   2405 C  CB  . VAL B 1 116 ? -49.49095 54.07052 -15.63230 1.000 74.62000  ? 96  VAL B CB  1 
ATOM   2406 C  CG1 . VAL B 1 116 ? -48.99300 55.34364 -16.34512 1.000 76.06000  ? 96  VAL B CG1 1 
ATOM   2407 C  CG2 . VAL B 1 116 ? -49.64150 52.90709 -16.60968 1.000 72.20000  ? 96  VAL B CG2 1 
ATOM   2408 N  N   . PHE B 1 117 ? -49.32209 55.15746 -12.63885 1.000 76.25000  ? 97  PHE B N   1 
ATOM   2409 C  CA  . PHE B 1 117 ? -49.23361 56.33277 -11.77901 1.000 75.25000  ? 97  PHE B CA  1 
ATOM   2410 C  C   . PHE B 1 117 ? -48.16282 56.17610 -10.70572 1.000 78.22000  ? 97  PHE B C   1 
ATOM   2411 O  O   . PHE B 1 117 ? -47.39272 57.10885 -10.45277 1.000 80.32000  ? 97  PHE B O   1 
ATOM   2412 C  CB  . PHE B 1 117 ? -50.58799 56.61175 -11.15099 1.000 72.62000  ? 97  PHE B CB  1 
ATOM   2413 C  CG  . PHE B 1 117 ? -51.64769 56.94216 -12.14999 1.000 72.15000  ? 97  PHE B CG  1 
ATOM   2414 C  CD1 . PHE B 1 117 ? -51.30449 57.38989 -13.41360 1.000 68.28000  ? 97  PHE B CD1 1 
ATOM   2415 C  CD2 . PHE B 1 117 ? -52.98473 56.81402 -11.82985 1.000 70.82000  ? 97  PHE B CD2 1 
ATOM   2416 C  CE1 . PHE B 1 117 ? -52.27395 57.69598 -14.34956 1.000 76.01000  ? 97  PHE B CE1 1 
ATOM   2417 C  CE2 . PHE B 1 117 ? -53.95951 57.12671 -12.75526 1.000 76.12000  ? 97  PHE B CE2 1 
ATOM   2418 C  CZ  . PHE B 1 117 ? -53.60135 57.56813 -14.02523 1.000 79.41000  ? 97  PHE B CZ  1 
ATOM   2419 N  N   . ALA B 1 118 ? -48.07774 55.01097 -10.06947 1.000 74.04000  ? 98  ALA B N   1 
ATOM   2420 C  CA  . ALA B 1 118 ? -47.00577 54.84277 -9.09029  1.000 74.71000  ? 98  ALA B CA  1 
ATOM   2421 C  C   . ALA B 1 118 ? -45.62689 54.85533 -9.72532  1.000 82.89000  ? 98  ALA B C   1 
ATOM   2422 O  O   . ALA B 1 118 ? -44.63027 54.74598 -8.99820  1.000 79.68000  ? 98  ALA B O   1 
ATOM   2423 C  CB  . ALA B 1 118 ? -47.17623 53.54897 -8.29724  1.000 75.77000  ? 98  ALA B CB  1 
ATOM   2424 N  N   . LEU B 1 119 ? -45.54657 54.95654 -11.05054 1.000 76.24000  ? 99  LEU B N   1 
ATOM   2425 C  CA  . LEU B 1 119 ? -44.28585 55.14784 -11.74293 1.000 86.73000  ? 99  LEU B CA  1 
ATOM   2426 C  C   . LEU B 1 119 ? -43.99898 56.62176 -12.00041 1.000 89.26000  ? 99  LEU B C   1 
ATOM   2427 O  O   . LEU B 1 119 ? -43.11569 56.94360 -12.80498 1.000 90.27000  ? 99  LEU B O   1 
ATOM   2428 C  CB  . LEU B 1 119 ? -44.28671 54.36066 -13.06040 1.000 80.56000  ? 99  LEU B CB  1 
ATOM   2429 C  CG  . LEU B 1 119 ? -43.71723 52.93652 -13.04221 1.000 79.31000  ? 99  LEU B CG  1 
ATOM   2430 N  N   . GLY B 1 120 ? -44.73874 57.52046 -11.35254 1.000 83.92000  ? 100 GLY B N   1 
ATOM   2431 C  CA  . GLY B 1 120 ? -44.52794 58.94068 -11.52028 1.000 87.41000  ? 100 GLY B CA  1 
ATOM   2432 C  C   . GLY B 1 120 ? -45.15994 59.57233 -12.74439 1.000 89.85000  ? 100 GLY B C   1 
ATOM   2433 O  O   . GLY B 1 120 ? -44.87977 60.74518 -13.02053 1.000 89.55000  ? 100 GLY B O   1 
ATOM   2434 N  N   . VAL B 1 121 ? -45.99920 58.85055 -13.48887 1.000 89.90000  ? 101 VAL B N   1 
ATOM   2435 C  CA  . VAL B 1 121 ? -46.67418 59.40924 -14.65738 1.000 86.80000  ? 101 VAL B CA  1 
ATOM   2436 C  C   . VAL B 1 121 ? -48.01139 59.98824 -14.22726 1.000 88.36000  ? 101 VAL B C   1 
ATOM   2437 O  O   . VAL B 1 121 ? -48.69743 59.42154 -13.36615 1.000 84.96000  ? 101 VAL B O   1 
ATOM   2438 C  CB  . VAL B 1 121 ? -46.85996 58.34666 -15.75548 1.000 84.49000  ? 101 VAL B CB  1 
ATOM   2439 C  CG1 . VAL B 1 121 ? -47.09456 59.01450 -17.08464 1.000 85.41000  ? 101 VAL B CG1 1 
ATOM   2440 C  CG2 . VAL B 1 121 ? -45.64731 57.45880 -15.83175 1.000 82.22000  ? 101 VAL B CG2 1 
ATOM   2441 N  N   . THR B 1 122 ? -48.41109 61.19123 -14.86817 1.000 88.57000  ? 102 THR B N   1 
ATOM   2442 C  CA  . THR B 1 122 ? -49.66866 61.85785 -14.55461 1.000 89.88000  ? 102 THR B CA  1 
ATOM   2443 C  C   . THR B 1 122 ? -50.80859 61.28019 -15.38360 1.000 88.58000  ? 102 THR B C   1 
ATOM   2444 O  O   . THR B 1 122 ? -50.57944 60.70826 -16.45313 1.000 82.94000  ? 102 THR B O   1 
ATOM   2445 C  CB  . THR B 1 122 ? -49.57636 63.36902 -14.81386 1.000 92.80000  ? 102 THR B CB  1 
ATOM   2446 O  OG1 . THR B 1 122 ? -49.93844 63.66361 -16.17582 1.000 94.38000  ? 102 THR B OG1 1 
ATOM   2447 C  CG2 . THR B 1 122 ? -48.17534 63.89779 -14.51813 1.000 87.01000  ? 102 THR B CG2 1 
ATOM   2448 N  N   . PRO B 1 123 ? -52.03767 61.40772 -14.87716 1.000 92.66000  ? 103 PRO B N   1 
ATOM   2449 C  CA  . PRO B 1 123 ? -53.20216 60.97984 -15.66888 1.000 87.46000  ? 103 PRO B CA  1 
ATOM   2450 C  C   . PRO B 1 123 ? -53.30499 61.68598 -17.00458 1.000 88.50000  ? 103 PRO B C   1 
ATOM   2451 O  O   . PRO B 1 123 ? -53.78529 61.09465 -17.97816 1.000 90.96000  ? 103 PRO B O   1 
ATOM   2452 C  CB  . PRO B 1 123 ? -54.39598 61.32982 -14.76871 1.000 92.33000  ? 103 PRO B CB  1 
ATOM   2453 C  CG  . PRO B 1 123 ? -53.84408 61.52820 -13.39339 1.000 88.41000  ? 103 PRO B CG  1 
ATOM   2454 C  CD  . PRO B 1 123 ? -52.35044 61.56598 -13.44491 1.000 82.41000  ? 103 PRO B CD  1 
ATOM   2455 N  N   . GLU B 1 124 ? -52.88283 62.94722 -17.07613 1.000 91.39000  ? 104 GLU B N   1 
ATOM   2456 C  CA  . GLU B 1 124 ? -52.91391 63.66201 -18.34530 1.000 91.34000  ? 104 GLU B CA  1 
ATOM   2457 C  C   . GLU B 1 124 ? -51.81738 63.17006 -19.27934 1.000 83.87000  ? 104 GLU B C   1 
ATOM   2458 O  O   . GLU B 1 124 ? -52.01494 63.13430 -20.49808 1.000 85.83000  ? 104 GLU B O   1 
ATOM   2459 C  CB  . GLU B 1 124 ? -52.79199 65.16814 -18.10047 1.000 88.43000  ? 104 GLU B CB  1 
ATOM   2460 C  CG  . GLU B 1 124 ? -53.97576 65.77811 -17.35966 1.000 93.49000  ? 104 GLU B CG  1 
ATOM   2461 C  CD  . GLU B 1 124 ? -53.98363 65.42502 -15.87242 1.000 97.38000  ? 104 GLU B CD  1 
ATOM   2462 O  OE1 . GLU B 1 124 ? -52.88089 65.34526 -15.28170 1.000 98.90000  ? 104 GLU B OE1 1 
ATOM   2463 O  OE2 . GLU B 1 124 ? -55.08041 65.21985 -15.29903 1.000 86.87000  ? 104 GLU B OE2 1 
ATOM   2464 N  N   . GLU B 1 125 ? -50.66638 62.77223 -18.73021 1.000 84.31000  ? 105 GLU B N   1 
ATOM   2465 C  CA  . GLU B 1 125 ? -49.60855 62.20024 -19.56130 1.000 86.55000  ? 105 GLU B CA  1 
ATOM   2466 C  C   . GLU B 1 125 ? -50.01265 60.83792 -20.11400 1.000 88.52000  ? 105 GLU B C   1 
ATOM   2467 O  O   . GLU B 1 125 ? -49.66363 60.49387 -21.24758 1.000 84.19000  ? 105 GLU B O   1 
ATOM   2468 C  CB  . GLU B 1 125 ? -48.31341 62.07871 -18.76241 1.000 88.24000  ? 105 GLU B CB  1 
ATOM   2469 C  CG  . GLU B 1 125 ? -47.70393 63.38954 -18.36518 1.000 89.94000  ? 105 GLU B CG  1 
ATOM   2470 C  CD  . GLU B 1 125 ? -46.48091 63.19362 -17.49988 1.000 99.52000  ? 105 GLU B CD  1 
ATOM   2471 O  OE1 . GLU B 1 125 ? -46.52908 62.31854 -16.61130 1.000 104.37000 ? 105 GLU B OE1 1 
ATOM   2472 O  OE2 . GLU B 1 125 ? -45.46665 63.89461 -17.71626 1.000 91.83000  ? 105 GLU B OE2 1 
ATOM   2473 N  N   . LEU B 1 126 ? -50.73321 60.04198 -19.32056 1.000 88.07000  ? 106 LEU B N   1 
ATOM   2474 C  CA  . LEU B 1 126 ? -51.18357 58.73187 -19.78237 1.000 86.29000  ? 106 LEU B CA  1 
ATOM   2475 C  C   . LEU B 1 126 ? -52.26096 58.86579 -20.85455 1.000 81.38000  ? 106 LEU B C   1 
ATOM   2476 O  O   . LEU B 1 126 ? -52.18924 58.21418 -21.90283 1.000 78.43000  ? 106 LEU B O   1 
ATOM   2477 C  CB  . LEU B 1 126 ? -51.69163 57.91378 -18.58840 1.000 80.24000  ? 106 LEU B CB  1 
ATOM   2478 C  CG  . LEU B 1 126 ? -52.49142 56.61884 -18.78763 1.000 89.79000  ? 106 LEU B CG  1 
ATOM   2479 N  N   . GLU B 1 127 ? -53.25555 59.73073 -20.61357 1.000 82.47000  ? 107 GLU B N   1 
ATOM   2480 C  CA  . GLU B 1 127 ? -54.38046 59.89278 -21.53275 1.000 88.27000  ? 107 GLU B CA  1 
ATOM   2481 C  C   . GLU B 1 127 ? -53.95704 60.48904 -22.86444 1.000 87.67000  ? 107 GLU B C   1 
ATOM   2482 O  O   . GLU B 1 127 ? -54.59433 60.21877 -23.88965 1.000 84.45000  ? 107 GLU B O   1 
ATOM   2483 C  CB  . GLU B 1 127 ? -55.45652 60.78475 -20.91293 1.000 86.40000  ? 107 GLU B CB  1 
ATOM   2484 C  CG  . GLU B 1 127 ? -56.29489 60.11216 -19.85074 1.000 89.90000  ? 107 GLU B CG  1 
ATOM   2485 C  CD  . GLU B 1 127 ? -56.87725 58.79922 -20.32719 1.000 92.11000  ? 107 GLU B CD  1 
ATOM   2486 O  OE1 . GLU B 1 127 ? -57.34102 58.73755 -21.49294 1.000 97.98000  ? 107 GLU B OE1 1 
ATOM   2487 O  OE2 . GLU B 1 127 ? -56.87236 57.83272 -19.53062 1.000 91.17000  ? 107 GLU B OE2 1 
ATOM   2488 N  N   . ALA B 1 128 ? -52.91290 61.31597 -22.86603 1.000 79.62000  ? 108 ALA B N   1 
ATOM   2489 C  CA  . ALA B 1 128 ? -52.49612 62.02121 -24.06962 1.000 86.34000  ? 108 ALA B CA  1 
ATOM   2490 C  C   . ALA B 1 128 ? -51.50739 61.23293 -24.91430 1.000 82.72000  ? 108 ALA B C   1 
ATOM   2491 O  O   . ALA B 1 128 ? -51.40632 61.49179 -26.12101 1.000 81.37000  ? 108 ALA B O   1 
ATOM   2492 C  CB  . ALA B 1 128 ? -51.88442 63.37394 -23.69789 1.000 82.77000  ? 108 ALA B CB  1 
ATOM   2493 N  N   . HIS B 1 129 ? -50.80055 60.28061 -24.30346 1.000 78.10000  ? 109 HIS B N   1 
ATOM   2494 C  CA  . HIS B 1 129 ? -49.80262 59.45319 -24.97696 1.000 81.98000  ? 109 HIS B CA  1 
ATOM   2495 C  C   . HIS B 1 129 ? -50.32420 58.87918 -26.28973 1.000 72.87000  ? 109 HIS B C   1 
ATOM   2496 O  O   . HIS B 1 129 ? -51.42615 58.32576 -26.35545 1.000 68.96000  ? 109 HIS B O   1 
ATOM   2497 C  CB  . HIS B 1 129 ? -49.38763 58.32761 -24.02916 1.000 76.50000  ? 109 HIS B CB  1 
ATOM   2498 C  CG  . HIS B 1 129 ? -48.44495 57.33170 -24.62318 1.000 77.27000  ? 109 HIS B CG  1 
ATOM   2499 N  ND1 . HIS B 1 129 ? -47.07759 57.40405 -24.44932 1.000 71.36000  ? 109 HIS B ND1 1 
ATOM   2500 C  CD2 . HIS B 1 129 ? -48.67363 56.21397 -25.35248 1.000 71.16000  ? 109 HIS B CD2 1 
ATOM   2501 C  CE1 . HIS B 1 129 ? -46.50416 56.38502 -25.06140 1.000 74.69000  ? 109 HIS B CE1 1 
ATOM   2502 N  NE2 . HIS B 1 129 ? -47.45021 55.64472 -25.61285 1.000 76.15000  ? 109 HIS B NE2 1 
ATOM   2503 N  N   . GLU B 1 130 ? -49.54009 59.05207 -27.34342 1.000 73.40000  ? 110 GLU B N   1 
ATOM   2504 C  CA  . GLU B 1 130 ? -49.86455 58.46987 -28.63249 1.000 73.93000  ? 110 GLU B CA  1 
ATOM   2505 C  C   . GLU B 1 130 ? -49.29731 57.05855 -28.69108 1.000 73.66000  ? 110 GLU B C   1 
ATOM   2506 O  O   . GLU B 1 130 ? -48.07541 56.89408 -28.55738 1.000 75.45000  ? 110 GLU B O   1 
ATOM   2507 C  CB  . GLU B 1 130 ? -49.29838 59.31379 -29.76220 0.601 31.63000  ? 110 GLU B CB  1 
ATOM   2508 C  CG  . GLU B 1 130 ? -50.13137 59.25125 -31.04560 0.562 31.63000  ? 110 GLU B CG  1 
ATOM   2509 C  CD  . GLU B 1 130 ? -51.59153 59.65160 -30.80507 0.847 31.63000  ? 110 GLU B CD  1 
ATOM   2510 N  N   . PRO B 1 131 ? -50.12690 56.02604 -28.83077 1.000 77.53000  ? 111 PRO B N   1 
ATOM   2511 C  CA  . PRO B 1 131 ? -49.59642 54.65772 -28.90578 1.000 79.08000  ? 111 PRO B CA  1 
ATOM   2512 C  C   . PRO B 1 131 ? -48.56702 54.54357 -30.01768 1.000 76.13000  ? 111 PRO B C   1 
ATOM   2513 O  O   . PRO B 1 131 ? -48.71950 55.14629 -31.07995 1.000 76.22000  ? 111 PRO B O   1 
ATOM   2514 C  CB  . PRO B 1 131 ? -50.83584 53.80666 -29.20230 1.000 74.61000  ? 111 PRO B CB  1 
ATOM   2515 C  CG  . PRO B 1 131 ? -51.98381 54.58315 -28.65420 1.000 81.60000  ? 111 PRO B CG  1 
ATOM   2516 C  CD  . PRO B 1 131 ? -51.59599 56.05120 -28.69144 1.000 83.09000  ? 111 PRO B CD  1 
ATOM   2517 N  N   . SER B 1 132 ? -47.51056 53.77309 -29.75755 1.000 75.47000  ? 112 SER B N   1 
ATOM   2518 C  CA  . SER B 1 132 ? -46.43950 53.61019 -30.72698 1.000 80.64000  ? 112 SER B CA  1 
ATOM   2519 C  C   . SER B 1 132 ? -46.90668 52.78611 -31.93202 1.000 77.36000  ? 112 SER B C   1 
ATOM   2520 O  O   . SER B 1 132 ? -47.99920 52.21468 -31.95351 1.000 79.41000  ? 112 SER B O   1 
ATOM   2521 C  CB  . SER B 1 132 ? -45.23662 52.93101 -30.08163 1.000 79.23000  ? 112 SER B CB  1 
ATOM   2522 O  OG  . SER B 1 132 ? -45.27393 51.52817 -30.31393 1.000 79.29000  ? 112 SER B OG  1 
ATOM   2523 N  N   . GLU B 1 133 ? -46.05151 52.71952 -32.95065 1.000 75.94000  ? 113 GLU B N   1 
ATOM   2524 C  CA  . GLU B 1 133 ? -46.35736 51.85406 -34.08202 1.000 80.01000  ? 113 GLU B CA  1 
ATOM   2525 C  C   . GLU B 1 133 ? -46.26808 50.38587 -33.68297 1.000 74.92000  ? 113 GLU B C   1 
ATOM   2526 O  O   . GLU B 1 133 ? -47.11744 49.57465 -34.07262 1.000 68.48000  ? 113 GLU B O   1 
ATOM   2527 C  CB  . GLU B 1 133 ? -45.42033 52.16005 -35.25370 1.000 85.14000  ? 113 GLU B CB  1 
ATOM   2528 C  CG  . GLU B 1 133 ? -45.85749 53.33892 -36.13628 1.000 89.43000  ? 113 GLU B CG  1 
ATOM   2529 C  CD  . GLU B 1 133 ? -47.33092 53.27823 -36.56630 1.000 94.99000  ? 113 GLU B CD  1 
ATOM   2530 O  OE1 . GLU B 1 133 ? -47.86842 52.16356 -36.77113 1.000 99.30000  ? 113 GLU B OE1 1 
ATOM   2531 O  OE2 . GLU B 1 133 ? -47.95156 54.35814 -36.71207 1.000 94.85000  ? 113 GLU B OE2 1 
ATOM   2532 N  N   . ALA B 1 134 ? -45.25534 50.02962 -32.88956 1.000 73.28000  ? 114 ALA B N   1 
ATOM   2533 C  CA  . ALA B 1 134 ? -45.14877 48.66055 -32.39769 1.000 78.67000  ? 114 ALA B CA  1 
ATOM   2534 C  C   . ALA B 1 134 ? -46.31622 48.29628 -31.48241 1.000 78.67000  ? 114 ALA B C   1 
ATOM   2535 O  O   . ALA B 1 134 ? -46.75992 47.13997 -31.47616 1.000 80.18000  ? 114 ALA B O   1 
ATOM   2536 C  CB  . ALA B 1 134 ? -43.81824 48.47138 -31.67107 1.000 68.44000  ? 114 ALA B CB  1 
ATOM   2537 N  N   . ALA B 1 135 ? -46.83515 49.26505 -30.71870 1.000 76.75000  ? 115 ALA B N   1 
ATOM   2538 C  CA  . ALA B 1 135 ? -47.99721 49.00109 -29.87790 1.000 76.03000  ? 115 ALA B CA  1 
ATOM   2539 C  C   . ALA B 1 135 ? -49.24569 48.75675 -30.71851 1.000 70.91000  ? 115 ALA B C   1 
ATOM   2540 O  O   . ALA B 1 135 ? -49.96052 47.77230 -30.50406 1.000 71.64000  ? 115 ALA B O   1 
ATOM   2541 C  CB  . ALA B 1 135 ? -48.21908 50.15634 -28.89618 1.000 75.36000  ? 115 ALA B CB  1 
ATOM   2542 N  N   . LYS B 1 136 ? -49.54048 49.64307 -31.67631 1.000 69.45000  ? 116 LYS B N   1 
ATOM   2543 C  CA  . LYS B 1 136 ? -50.70632 49.39893 -32.52194 1.000 72.31000  ? 116 LYS B CA  1 
ATOM   2544 C  C   . LYS B 1 136 ? -50.55534 48.09275 -33.28591 1.000 71.74000  ? 116 LYS B C   1 
ATOM   2545 O  O   . LYS B 1 136 ? -51.55626 47.46332 -33.65133 1.000 70.54000  ? 116 LYS B O   1 
ATOM   2546 C  CB  . LYS B 1 136 ? -50.93658 50.55999 -33.49061 0.749 34.08000  ? 116 LYS B CB  1 
ATOM   2547 C  CG  . LYS B 1 136 ? -50.97089 51.92943 -32.83615 0.739 34.08000  ? 116 LYS B CG  1 
ATOM   2548 C  CD  . LYS B 1 136 ? -51.04808 53.06719 -33.88411 0.653 34.08000  ? 116 LYS B CD  1 
ATOM   2549 C  CE  . LYS B 1 136 ? -49.97636 54.10951 -33.58067 0.476 34.08000  ? 116 LYS B CE  1 
ATOM   2550 N  NZ  . LYS B 1 136 ? -49.78093 55.19354 -34.58976 0.619 34.08000  ? 116 LYS B NZ  1 
ATOM   2551 N  N   . ALA B 1 137 ? -49.31212 47.65287 -33.49583 1.000 71.43000  ? 117 ALA B N   1 
ATOM   2552 C  CA  . ALA B 1 137 ? -49.06509 46.43048 -34.25074 1.000 73.85000  ? 117 ALA B CA  1 
ATOM   2553 C  C   . ALA B 1 137 ? -49.37110 45.20127 -33.40599 1.000 67.18000  ? 117 ALA B C   1 
ATOM   2554 O  O   . ALA B 1 137 ? -50.00629 44.24532 -33.87294 1.000 61.81000  ? 117 ALA B O   1 
ATOM   2555 C  CB  . ALA B 1 137 ? -47.61292 46.40863 -34.72578 1.000 75.22000  ? 117 ALA B CB  1 
ATOM   2556 N  N   . LYS B 1 138 ? -48.90457 45.20678 -32.15660 1.000 70.36000  ? 118 LYS B N   1 
ATOM   2557 C  CA  . LYS B 1 138 ? -49.22192 44.11236 -31.24946 1.000 63.74000  ? 118 LYS B CA  1 
ATOM   2558 C  C   . LYS B 1 138 ? -50.73279 43.92663 -31.13236 1.000 63.44000  ? 118 LYS B C   1 
ATOM   2559 O  O   . LYS B 1 138 ? -51.22918 42.79687 -31.17851 1.000 61.78000  ? 118 LYS B O   1 
ATOM   2560 C  CB  . LYS B 1 138 ? -48.56725 44.36901 -29.89172 1.000 71.11000  ? 118 LYS B CB  1 
ATOM   2561 C  CG  . LYS B 1 138 ? -48.86179 43.34060 -28.82007 1.000 70.12000  ? 118 LYS B CG  1 
ATOM   2562 C  CD  . LYS B 1 138 ? -48.53320 43.88357 -27.45087 1.000 72.58000  ? 118 LYS B CD  1 
ATOM   2563 C  CE  . LYS B 1 138 ? -49.23214 45.19967 -27.19350 1.000 74.54000  ? 118 LYS B CE  1 
ATOM   2564 N  NZ  . LYS B 1 138 ? -49.01708 45.63436 -25.77967 1.000 72.54000  ? 118 LYS B NZ  1 
ATOM   2565 N  N   . VAL B 1 139 ? -51.49239 45.02181 -31.09315 1.000 65.11000  ? 119 VAL B N   1 
ATOM   2566 C  CA  . VAL B 1 139 ? -52.93098 44.86397 -30.91704 1.000 63.35000  ? 119 VAL B CA  1 
ATOM   2567 C  C   . VAL B 1 139 ? -53.59460 44.30408 -32.17522 1.000 67.25000  ? 119 VAL B C   1 
ATOM   2568 O  O   . VAL B 1 139 ? -54.57113 43.55399 -32.07981 1.000 67.88000  ? 119 VAL B O   1 
ATOM   2569 C  CB  . VAL B 1 139 ? -53.55826 46.20012 -30.47012 1.000 62.03000  ? 119 VAL B CB  1 
ATOM   2570 C  CG1 . VAL B 1 139 ? -55.06758 46.11339 -30.45492 1.000 54.22000  ? 119 VAL B CG1 1 
ATOM   2571 C  CG2 . VAL B 1 139 ? -53.05455 46.57057 -29.09435 1.000 65.21000  ? 119 VAL B CG2 1 
ATOM   2572 N  N   . ALA B 1 140 ? -53.10182 44.63921 -33.37084 1.000 68.71000  ? 120 ALA B N   1 
ATOM   2573 C  CA  . ALA B 1 140 ? -53.80504 44.16717 -34.57075 1.000 66.04000  ? 120 ALA B CA  1 
ATOM   2574 C  C   . ALA B 1 140 ? -53.59230 42.66999 -34.80800 1.000 64.22000  ? 120 ALA B C   1 
ATOM   2575 O  O   . ALA B 1 140 ? -54.45819 42.00853 -35.39074 1.000 70.57000  ? 120 ALA B O   1 
ATOM   2576 C  CB  . ALA B 1 140 ? -53.39111 44.97900 -35.81228 1.000 58.61000  ? 120 ALA B CB  1 
ATOM   2577 N  N   . THR B 1 141 ? -52.46421 42.11345 -34.36798 1.000 63.01000  ? 121 THR B N   1 
ATOM   2578 C  CA  . THR B 1 141 ? -52.29806 40.66564 -34.45955 1.000 64.08000  ? 121 THR B CA  1 
ATOM   2579 C  C   . THR B 1 141 ? -53.31620 39.93390 -33.59560 1.000 67.82000  ? 121 THR B C   1 
ATOM   2580 O  O   . THR B 1 141 ? -53.98618 39.00895 -34.06364 1.000 67.95000  ? 121 THR B O   1 
ATOM   2581 C  CB  . THR B 1 141 ? -50.88582 40.25521 -34.06153 1.000 66.41000  ? 121 THR B CB  1 
ATOM   2582 O  OG1 . THR B 1 141 ? -49.93843 41.20419 -34.57115 1.000 67.62000  ? 121 THR B OG1 1 
ATOM   2583 C  CG2 . THR B 1 141 ? -50.59469 38.86818 -34.58091 1.000 69.02000  ? 121 THR B CG2 1 
ATOM   2584 N  N   . PHE B 1 142 ? -53.42797 40.31833 -32.32214 1.000 69.28000  ? 122 PHE B N   1 
ATOM   2585 C  CA  . PHE B 1 142 ? -54.46367 39.74639 -31.47430 1.000 61.73000  ? 122 PHE B CA  1 
ATOM   2586 C  C   . PHE B 1 142 ? -55.81208 39.90715 -32.13342 1.000 61.90000  ? 122 PHE B C   1 
ATOM   2587 O  O   . PHE B 1 142 ? -56.56991 38.94587 -32.28355 1.000 64.27000  ? 122 PHE B O   1 
ATOM   2588 C  CB  . PHE B 1 142 ? -54.46678 40.42078 -30.09587 1.000 59.45000  ? 122 PHE B CB  1 
ATOM   2589 C  CG  . PHE B 1 142 ? -53.35997 39.96927 -29.20247 1.000 61.24000  ? 122 PHE B CG  1 
ATOM   2590 C  CD1 . PHE B 1 142 ? -53.34215 38.68272 -28.70275 1.000 57.51000  ? 122 PHE B CD1 1 
ATOM   2591 C  CD2 . PHE B 1 142 ? -52.32294 40.81723 -28.89004 1.000 60.37000  ? 122 PHE B CD2 1 
ATOM   2592 C  CE1 . PHE B 1 142 ? -52.31442 38.25619 -27.90750 1.000 57.73000  ? 122 PHE B CE1 1 
ATOM   2593 C  CE2 . PHE B 1 142 ? -51.29551 40.40186 -28.08398 1.000 65.25000  ? 122 PHE B CE2 1 
ATOM   2594 C  CZ  . PHE B 1 142 ? -51.28843 39.11722 -27.58639 1.000 56.58000  ? 122 PHE B CZ  1 
ATOM   2595 N  N   . MET B 1 143 ? -56.10953 41.12568 -32.56441 1.000 62.27000  ? 123 MET B N   1 
ATOM   2596 C  CA  . MET B 1 143 ? -57.43940 41.42271 -33.06181 1.000 61.22000  ? 123 MET B CA  1 
ATOM   2597 C  C   . MET B 1 143 ? -57.72363 40.67501 -34.34817 1.000 63.57000  ? 123 MET B C   1 
ATOM   2598 O  O   . MET B 1 143 ? -58.86021 40.25195 -34.57092 1.000 64.02000  ? 123 MET B O   1 
ATOM   2599 C  CB  . MET B 1 143 ? -57.58044 42.92238 -33.27103 1.000 67.67000  ? 123 MET B CB  1 
ATOM   2600 C  CG  . MET B 1 143 ? -59.00878 43.36348 -33.40382 1.000 74.14000  ? 123 MET B CG  1 
ATOM   2601 S  SD  . MET B 1 143 ? -59.83873 43.38812 -31.80801 1.000 85.32000  ? 123 MET B SD  1 
ATOM   2602 C  CE  . MET B 1 143 ? -61.29683 42.40079 -32.16286 1.000 66.66000  ? 123 MET B CE  1 
ATOM   2603 N  N   . ARG B 1 144 ? -56.69759 40.51048 -35.19192 1.000 61.21000  ? 124 ARG B N   1 
ATOM   2604 C  CA  . ARG B 1 144 ? -56.83284 39.76948 -36.44129 1.000 72.02000  ? 124 ARG B CA  1 
ATOM   2605 C  C   . ARG B 1 144 ? -57.34005 38.35880 -36.18593 1.000 62.51000  ? 124 ARG B C   1 
ATOM   2606 O  O   . ARG B 1 144 ? -58.27965 37.88471 -36.84286 1.000 61.54000  ? 124 ARG B O   1 
ATOM   2607 C  CB  . ARG B 1 144 ? -55.48236 39.72405 -37.16968 1.000 69.96000  ? 124 ARG B CB  1 
ATOM   2608 C  CG  . ARG B 1 144 ? -55.64148 39.69944 -38.65716 1.000 75.64000  ? 124 ARG B CG  1 
ATOM   2609 C  CD  . ARG B 1 144 ? -54.32943 39.78136 -39.47060 1.000 73.96000  ? 124 ARG B CD  1 
ATOM   2610 N  NE  . ARG B 1 144 ? -53.10088 39.38581 -38.78962 1.000 74.27000  ? 124 ARG B NE  1 
ATOM   2611 C  CZ  . ARG B 1 144 ? -52.23205 40.23932 -38.26122 1.000 74.96000  ? 124 ARG B CZ  1 
ATOM   2612 N  NH1 . ARG B 1 144 ? -52.50028 41.53491 -38.17364 1.000 74.56000  ? 124 ARG B NH1 1 
ATOM   2613 N  NH2 . ARG B 1 144 ? -51.07145 39.78110 -37.79636 1.000 70.72000  ? 124 ARG B NH2 1 
ATOM   2614 N  N   . TRP B 1 145 ? -56.71731 37.67453 -35.22884 1.000 60.75000  ? 125 TRP B N   1 
ATOM   2615 C  CA  . TRP B 1 145 ? -57.04017 36.28254 -34.95369 1.000 61.08000  ? 125 TRP B CA  1 
ATOM   2616 C  C   . TRP B 1 145 ? -58.37058 36.13407 -34.23298 1.000 62.79000  ? 125 TRP B C   1 
ATOM   2617 O  O   . TRP B 1 145 ? -59.13462 35.20817 -34.52106 1.000 59.09000  ? 125 TRP B O   1 
ATOM   2618 C  CB  . TRP B 1 145 ? -55.91652 35.67163 -34.14715 1.000 60.99000  ? 125 TRP B CB  1 
ATOM   2619 C  CG  . TRP B 1 145 ? -54.76297 35.39448 -34.98877 1.000 58.19000  ? 125 TRP B CG  1 
ATOM   2620 C  CD1 . TRP B 1 145 ? -53.56402 36.02869 -34.96725 1.000 58.19000  ? 125 TRP B CD1 1 
ATOM   2621 C  CD2 . TRP B 1 145 ? -54.68316 34.40416 -36.01609 1.000 65.05000  ? 125 TRP B CD2 1 
ATOM   2622 N  NE1 . TRP B 1 145 ? -52.72421 35.47558 -35.90335 1.000 67.33000  ? 125 TRP B NE1 1 
ATOM   2623 C  CE2 . TRP B 1 145 ? -53.39291 34.47994 -36.56618 1.000 69.56000  ? 125 TRP B CE2 1 
ATOM   2624 C  CE3 . TRP B 1 145 ? -55.57881 33.44904 -36.51874 1.000 66.60000  ? 125 TRP B CE3 1 
ATOM   2625 C  CZ2 . TRP B 1 145 ? -52.97069 33.63818 -37.59899 1.000 73.90000  ? 125 TRP B CZ2 1 
ATOM   2626 C  CZ3 . TRP B 1 145 ? -55.15940 32.61501 -37.55222 1.000 60.71000  ? 125 TRP B CZ3 1 
ATOM   2627 C  CH2 . TRP B 1 145 ? -53.86616 32.71335 -38.07021 1.000 67.66000  ? 125 TRP B CH2 1 
ATOM   2628 N  N   . CYS B 1 146 ? -58.67854 37.05277 -33.32098 1.000 60.12000  ? 126 CYS B N   1 
ATOM   2629 C  CA  . CYS B 1 146 ? -59.92222 36.94564 -32.57768 1.000 58.44000  ? 126 CYS B CA  1 
ATOM   2630 C  C   . CYS B 1 146 ? -61.13755 37.23826 -33.42940 1.000 61.07000  ? 126 CYS B C   1 
ATOM   2631 O  O   . CYS B 1 146 ? -62.23278 36.80312 -33.06313 1.000 62.54000  ? 126 CYS B O   1 
ATOM   2632 C  CB  . CYS B 1 146 ? -59.90357 37.87396 -31.35393 1.000 65.30000  ? 126 CYS B CB  1 
ATOM   2633 S  SG  . CYS B 1 146 ? -58.69314 37.40726 -30.08307 1.000 62.24000  ? 126 CYS B SG  1 
ATOM   2634 N  N   . THR B 1 147 ? -60.97342 37.96563 -34.54038 1.000 68.47000  ? 127 THR B N   1 
ATOM   2635 C  CA  . THR B 1 147 ? -62.03900 38.21692 -35.50965 1.000 69.60000  ? 127 THR B CA  1 
ATOM   2636 C  C   . THR B 1 147 ? -61.94439 37.33269 -36.74104 1.000 71.75000  ? 127 THR B C   1 
ATOM   2637 O  O   . THR B 1 147 ? -62.75907 37.48935 -37.66062 1.000 68.94000  ? 127 THR B O   1 
ATOM   2638 C  CB  . THR B 1 147 ? -62.04248 39.68394 -35.97771 1.000 70.37000  ? 127 THR B CB  1 
ATOM   2639 O  OG1 . THR B 1 147 ? -60.73600 40.06373 -36.42536 1.000 60.64000  ? 127 THR B OG1 1 
ATOM   2640 C  CG2 . THR B 1 147 ? -62.50846 40.61268 -34.89766 1.000 69.22000  ? 127 THR B CG2 1 
ATOM   2641 N  N   . GLY B 1 148 ? -60.96227 36.43336 -36.79074 1.000 72.38000  ? 128 GLY B N   1 
ATOM   2642 C  CA  . GLY B 1 148 ? -60.77521 35.55213 -37.92138 1.000 66.37000  ? 128 GLY B CA  1 
ATOM   2643 C  C   . GLY B 1 148 ? -61.88687 34.54003 -38.08560 1.000 69.67000  ? 128 GLY B C   1 
ATOM   2644 O  O   . GLY B 1 148 ? -63.00296 34.71266 -37.59091 1.000 70.04000  ? 128 GLY B O   1 
ATOM   2645 N  N   . ASP B 1 149 ? -61.58792 33.47229 -38.80167 1.000 71.55000  ? 129 ASP B N   1 
ATOM   2646 C  CA  . ASP B 1 149 ? -62.56883 32.44056 -39.07568 1.000 76.29000  ? 129 ASP B CA  1 
ATOM   2647 C  C   . ASP B 1 149 ? -62.36753 31.21694 -38.20287 1.000 67.33000  ? 129 ASP B C   1 
ATOM   2648 O  O   . ASP B 1 149 ? -63.24464 30.35330 -38.16150 1.000 69.66000  ? 129 ASP B O   1 
ATOM   2649 C  CB  . ASP B 1 149 ? -62.51238 32.04663 -40.56672 1.000 79.58000  ? 129 ASP B CB  1 
ATOM   2650 C  CG  . ASP B 1 149 ? -61.10048 31.66283 -41.02936 0.563 92.19000  ? 129 ASP B CG  1 
ATOM   2651 O  OD1 . ASP B 1 149 ? -60.28706 31.18896 -40.20296 0.947 100.17000 ? 129 ASP B OD1 1 
ATOM   2652 O  OD2 . ASP B 1 149 ? -60.78369 31.86624 -42.22239 0.895 97.71000  ? 129 ASP B OD2 1 
ATOM   2653 N  N   . SER B 1 150 ? -61.23127 31.11508 -37.53099 1.000 67.51000  ? 130 SER B N   1 
ATOM   2654 C  CA  . SER B 1 150 ? -60.92503 29.95913 -36.69161 1.000 74.15000  ? 130 SER B CA  1 
ATOM   2655 C  C   . SER B 1 150 ? -61.13421 30.35321 -35.23047 1.000 64.76000  ? 130 SER B C   1 
ATOM   2656 O  O   . SER B 1 150 ? -60.31461 31.05983 -34.63893 1.000 64.56000  ? 130 SER B O   1 
ATOM   2657 C  CB  . SER B 1 150 ? -59.50713 29.46180 -36.94954 1.000 67.07000  ? 130 SER B CB  1 
ATOM   2658 O  OG  . SER B 1 150 ? -59.19132 28.35510 -36.11232 1.000 68.85000  ? 130 SER B OG  1 
ATOM   2659 N  N   . LEU B 1 151 ? -62.25124 29.90453 -34.66037 1.000 58.55000  ? 131 LEU B N   1 
ATOM   2660 C  CA  . LEU B 1 151 ? -62.50334 30.15110 -33.24323 1.000 58.39000  ? 131 LEU B CA  1 
ATOM   2661 C  C   . LEU B 1 151 ? -61.39156 29.56623 -32.38522 1.000 59.33000  ? 131 LEU B C   1 
ATOM   2662 O  O   . LEU B 1 151 ? -60.91301 30.21490 -31.44300 1.000 57.72000  ? 131 LEU B O   1 
ATOM   2663 C  CB  . LEU B 1 151 ? -63.85562 29.56650 -32.83680 1.000 57.55000  ? 131 LEU B CB  1 
ATOM   2664 C  CG  . LEU B 1 151 ? -65.13101 30.36829 -33.13286 1.000 53.79000  ? 131 LEU B CG  1 
ATOM   2665 C  CD1 . LEU B 1 151 ? -66.36180 29.65323 -32.66018 1.000 52.42000  ? 131 LEU B CD1 1 
ATOM   2666 C  CD2 . LEU B 1 151 ? -65.09423 31.73213 -32.49881 1.000 61.53000  ? 131 LEU B CD2 1 
ATOM   2667 N  N   . ALA B 1 152 ? -60.94605 28.34539 -32.70816 1.000 57.86000  ? 132 ALA B N   1 
ATOM   2668 C  CA  . ALA B 1 152 ? -59.84079 27.75507 -31.95742 1.000 59.75000  ? 132 ALA B CA  1 
ATOM   2669 C  C   . ALA B 1 152 ? -58.57566 28.61218 -32.05561 1.000 52.31000  ? 132 ALA B C   1 
ATOM   2670 O  O   . ALA B 1 152 ? -57.85493 28.78242 -31.06727 1.000 60.23000  ? 132 ALA B O   1 
ATOM   2671 C  CB  . ALA B 1 152 ? -59.59327 26.32851 -32.44554 1.000 59.96000  ? 132 ALA B CB  1 
ATOM   2672 N  N   . ALA B 1 153 ? -58.31871 29.20521 -33.22697 1.000 54.07000  ? 133 ALA B N   1 
ATOM   2673 C  CA  . ALA B 1 153 ? -57.10479 29.99124 -33.41306 1.000 54.22000  ? 133 ALA B CA  1 
ATOM   2674 C  C   . ALA B 1 153 ? -57.18145 31.33201 -32.70978 1.000 54.19000  ? 133 ALA B C   1 
ATOM   2675 O  O   . ALA B 1 153 ? -56.14761 31.86684 -32.29961 1.000 53.19000  ? 133 ALA B O   1 
ATOM   2676 C  CB  . ALA B 1 153 ? -56.82790 30.21507 -34.90209 1.000 59.97000  ? 133 ALA B CB  1 
ATOM   2677 N  N   . GLY B 1 154 ? -58.37680 31.90805 -32.58796 1.000 63.04000  ? 134 GLY B N   1 
ATOM   2678 C  CA  . GLY B 1 154 ? -58.55251 33.09863 -31.77531 1.000 59.39000  ? 134 GLY B CA  1 
ATOM   2679 C  C   . GLY B 1 154 ? -58.13979 32.88084 -30.33115 1.000 58.63000  ? 134 GLY B C   1 
ATOM   2680 O  O   . GLY B 1 154 ? -57.27882 33.59314 -29.79391 1.000 56.62000  ? 134 GLY B O   1 
ATOM   2681 N  N   . VAL B 1 155 ? -58.74983 31.88125 -29.69175 1.000 61.72000  ? 135 VAL B N   1 
ATOM   2682 C  CA  . VAL B 1 155 ? -58.36052 31.51364 -28.32762 1.000 50.34000  ? 135 VAL B CA  1 
ATOM   2683 C  C   . VAL B 1 155 ? -56.85791 31.29539 -28.26366 1.000 56.27000  ? 135 VAL B C   1 
ATOM   2684 O  O   . VAL B 1 155 ? -56.15748 31.88443 -27.42908 1.000 58.72000  ? 135 VAL B O   1 
ATOM   2685 C  CB  . VAL B 1 155 ? -59.13784 30.26370 -27.86734 1.000 52.27000  ? 135 VAL B CB  1 
ATOM   2686 C  CG1 . VAL B 1 155 ? -58.74461 29.85302 -26.45887 1.000 55.90000  ? 135 VAL B CG1 1 
ATOM   2687 C  CG2 . VAL B 1 155 ? -60.62659 30.49841 -27.96185 1.000 48.48000  ? 135 VAL B CG2 1 
ATOM   2688 N  N   . ALA B 1 156 ? -56.33578 30.47554 -29.18610 1.000 58.19000  ? 136 ALA B N   1 
ATOM   2689 C  CA  . ALA B 1 156 ? -54.91629 30.14498 -29.18612 1.000 57.59000  ? 136 ALA B CA  1 
ATOM   2690 C  C   . ALA B 1 156 ? -54.04311 31.39161 -29.21128 1.000 56.54000  ? 136 ALA B C   1 
ATOM   2691 O  O   . ALA B 1 156 ? -52.94203 31.38855 -28.64761 1.000 59.40000  ? 136 ALA B O   1 
ATOM   2692 C  CB  . ALA B 1 156 ? -54.59751 29.22806 -30.37184 1.000 52.56000  ? 136 ALA B CB  1 
ATOM   2693 N  N   . ALA B 1 157 ? -54.52152 32.47064 -29.83416 1.000 57.28000  ? 137 ALA B N   1 
ATOM   2694 C  CA  . ALA B 1 157 ? -53.75058 33.70676 -29.84410 1.000 53.71000  ? 137 ALA B CA  1 
ATOM   2695 C  C   . ALA B 1 157 ? -53.67505 34.29378 -28.44128 1.000 59.17000  ? 137 ALA B C   1 
ATOM   2696 O  O   . ALA B 1 157 ? -52.61144 34.72671 -27.98458 1.000 58.49000  ? 137 ALA B O   1 
ATOM   2697 C  CB  . ALA B 1 157 ? -54.37095 34.71050 -30.82201 1.000 54.45000  ? 137 ALA B CB  1 
ATOM   2698 N  N   . LEU B 1 158 ? -54.80690 34.32821 -27.75146 1.000 53.08000  ? 138 LEU B N   1 
ATOM   2699 C  CA  . LEU B 1 158 ? -54.81013 34.77156 -26.37475 1.000 57.92000  ? 138 LEU B CA  1 
ATOM   2700 C  C   . LEU B 1 158 ? -53.95046 33.85550 -25.52017 1.000 58.19000  ? 138 LEU B C   1 
ATOM   2701 O  O   . LEU B 1 158 ? -53.08704 34.32570 -24.76860 1.000 57.62000  ? 138 LEU B O   1 
ATOM   2702 C  CB  . LEU B 1 158 ? -56.24633 34.82950 -25.86995 1.000 55.58000  ? 138 LEU B CB  1 
ATOM   2703 C  CG  . LEU B 1 158 ? -57.05812 35.73664 -26.78024 1.000 59.90000  ? 138 LEU B CG  1 
ATOM   2704 C  CD1 . LEU B 1 158 ? -58.51220 35.82881 -26.33402 1.000 60.02000  ? 138 LEU B CD1 1 
ATOM   2705 C  CD2 . LEU B 1 158 ? -56.38748 37.10787 -26.83008 1.000 61.21000  ? 138 LEU B CD2 1 
ATOM   2706 N  N   . TYR B 1 159 ? -54.13335 32.53656 -25.67201 1.000 59.59000  ? 139 TYR B N   1 
ATOM   2707 C  CA  . TYR B 1 159 ? -53.40100 31.57917 -24.84402 1.000 58.80000  ? 139 TYR B CA  1 
ATOM   2708 C  C   . TYR B 1 159 ? -51.90060 31.81428 -24.93252 1.000 58.72000  ? 139 TYR B C   1 
ATOM   2709 O  O   . TYR B 1 159 ? -51.17334 31.65884 -23.94725 1.000 60.07000  ? 139 TYR B O   1 
ATOM   2710 C  CB  . TYR B 1 159 ? -53.76176 30.14637 -25.26416 1.000 56.86000  ? 139 TYR B CB  1 
ATOM   2711 C  CG  . TYR B 1 159 ? -52.99880 29.05757 -24.54325 1.000 63.23000  ? 139 TYR B CG  1 
ATOM   2712 C  CD1 . TYR B 1 159 ? -53.48499 28.49922 -23.36455 1.000 58.14000  ? 139 TYR B CD1 1 
ATOM   2713 C  CD2 . TYR B 1 159 ? -51.78772 28.59775 -25.02609 1.000 64.15000  ? 139 TYR B CD2 1 
ATOM   2714 C  CE1 . TYR B 1 159 ? -52.77757 27.50231 -22.68466 1.000 65.29000  ? 139 TYR B CE1 1 
ATOM   2715 C  CE2 . TYR B 1 159 ? -51.07476 27.61797 -24.36033 1.000 59.21000  ? 139 TYR B CE2 1 
ATOM   2716 C  CZ  . TYR B 1 159 ? -51.57255 27.06826 -23.18898 1.000 69.63000  ? 139 TYR B CZ  1 
ATOM   2717 O  OH  . TYR B 1 159 ? -50.86367 26.08495 -22.53830 1.000 62.34000  ? 139 TYR B OH  1 
ATOM   2718 N  N   . SER B 1 160 ? -51.42196 32.20774 -26.11030 1.000 61.65000  ? 140 SER B N   1 
ATOM   2719 C  CA  . SER B 1 160 ? -49.99871 32.43730 -26.31038 1.000 62.39000  ? 140 SER B CA  1 
ATOM   2720 C  C   . SER B 1 160 ? -49.48529 33.60369 -25.47711 1.000 67.26000  ? 140 SER B C   1 
ATOM   2721 O  O   . SER B 1 160 ? -48.28093 33.67620 -25.20107 1.000 65.11000  ? 140 SER B O   1 
ATOM   2722 C  CB  . SER B 1 160 ? -49.72779 32.67487 -27.79872 1.000 60.80000  ? 140 SER B CB  1 
ATOM   2723 O  OG  . SER B 1 160 ? -50.52370 31.81290 -28.58747 1.000 62.53000  ? 140 SER B OG  1 
ATOM   2724 N  N   . TYR B 1 161 ? -50.36518 34.51933 -25.08293 1.000 62.11000  ? 141 TYR B N   1 
ATOM   2725 C  CA  . TYR B 1 161 ? -49.96979 35.62845 -24.23485 1.000 60.58000  ? 141 TYR B CA  1 
ATOM   2726 C  C   . TYR B 1 161 ? -50.17648 35.28898 -22.77043 1.000 59.69000  ? 141 TYR B C   1 
ATOM   2727 O  O   . TYR B 1 161 ? -49.27501 35.46238 -21.94609 1.000 56.04000  ? 141 TYR B O   1 
ATOM   2728 C  CB  . TYR B 1 161 ? -50.78621 36.86553 -24.59366 1.000 66.38000  ? 141 TYR B CB  1 
ATOM   2729 C  CG  . TYR B 1 161 ? -50.59341 38.05716 -23.66554 1.000 67.37000  ? 141 TYR B CG  1 
ATOM   2730 C  CD1 . TYR B 1 161 ? -49.37366 38.72225 -23.59646 1.000 70.04000  ? 141 TYR B CD1 1 
ATOM   2731 C  CD2 . TYR B 1 161 ? -51.63901 38.53106 -22.87848 1.000 61.56000  ? 141 TYR B CD2 1 
ATOM   2732 C  CE1 . TYR B 1 161 ? -49.19959 39.81598 -22.77973 1.000 66.66000  ? 141 TYR B CE1 1 
ATOM   2733 C  CE2 . TYR B 1 161 ? -51.47289 39.63885 -22.06449 1.000 70.58000  ? 141 TYR B CE2 1 
ATOM   2734 C  CZ  . TYR B 1 161 ? -50.24813 40.27238 -22.02088 1.000 67.46000  ? 141 TYR B CZ  1 
ATOM   2735 O  OH  . TYR B 1 161 ? -50.06931 41.36932 -21.21447 1.000 76.30000  ? 141 TYR B OH  1 
ATOM   2736 N  N   . GLU B 1 162 ? -51.36283 34.77642 -22.45706 1.000 61.87000  ? 142 GLU B N   1 
ATOM   2737 C  CA  . GLU B 1 162 ? -51.76540 34.63117 -21.07385 1.000 60.42000  ? 142 GLU B CA  1 
ATOM   2738 C  C   . GLU B 1 162 ? -50.98265 33.52220 -20.38105 1.000 61.94000  ? 142 GLU B C   1 
ATOM   2739 O  O   . GLU B 1 162 ? -50.61618 33.66640 -19.20705 1.000 66.86000  ? 142 GLU B O   1 
ATOM   2740 C  CB  . GLU B 1 162 ? -53.27007 34.40546 -21.02135 1.000 66.56000  ? 142 GLU B CB  1 
ATOM   2741 C  CG  . GLU B 1 162 ? -54.04371 35.72002 -20.89634 1.000 56.12000  ? 142 GLU B CG  1 
ATOM   2742 C  CD  . GLU B 1 162 ? -55.53122 35.55314 -21.10969 1.000 69.19000  ? 142 GLU B CD  1 
ATOM   2743 O  OE1 . GLU B 1 162 ? -55.92665 35.16487 -22.22989 1.000 64.30000  ? 142 GLU B OE1 1 
ATOM   2744 O  OE2 . GLU B 1 162 ? -56.31145 35.81885 -20.17488 1.000 63.64000  ? 142 GLU B OE2 1 
ATOM   2745 N  N   . SER B 1 163 ? -50.64051 32.44713 -21.10831 1.000 64.36000  ? 143 SER B N   1 
ATOM   2746 C  CA  . SER B 1 163 ? -49.90323 31.32820 -20.51039 1.000 58.89000  ? 143 SER B CA  1 
ATOM   2747 C  C   . SER B 1 163 ? -48.54400 31.74002 -19.94146 1.000 66.42000  ? 143 SER B C   1 
ATOM   2748 O  O   . SER B 1 163 ? -48.01068 31.03750 -19.07364 1.000 66.80000  ? 143 SER B O   1 
ATOM   2749 C  CB  . SER B 1 163 ? -49.70907 30.18058 -21.52405 1.000 64.79000  ? 143 SER B CB  1 
ATOM   2750 O  OG  . SER B 1 163 ? -49.20466 30.61984 -22.78944 1.000 65.53000  ? 143 SER B OG  1 
ATOM   2751 N  N   . GLN B 1 164 ? -47.97789 32.85990 -20.39661 1.000 61.58000  ? 144 GLN B N   1 
ATOM   2752 C  CA  . GLN B 1 164 ? -46.69028 33.34150 -19.90397 1.000 61.59000  ? 144 GLN B CA  1 
ATOM   2753 C  C   . GLN B 1 164 ? -46.81168 34.29678 -18.72754 1.000 69.31000  ? 144 GLN B C   1 
ATOM   2754 O  O   . GLN B 1 164 ? -45.82109 34.51680 -18.00986 1.000 70.07000  ? 144 GLN B O   1 
ATOM   2755 C  CB  . GLN B 1 164 ? -45.93262 34.06889 -21.01456 1.000 72.16000  ? 144 GLN B CB  1 
ATOM   2756 C  CG  . GLN B 1 164 ? -45.91588 33.33792 -22.33419 1.000 67.70000  ? 144 GLN B CG  1 
ATOM   2757 C  CD  . GLN B 1 164 ? -45.28736 34.16895 -23.41921 1.000 73.56000  ? 144 GLN B CD  1 
ATOM   2758 O  OE1 . GLN B 1 164 ? -44.16552 34.65431 -23.27592 1.000 74.32000  ? 144 GLN B OE1 1 
ATOM   2759 N  NE2 . GLN B 1 164 ? -46.01609 34.35762 -24.51097 1.000 62.97000  ? 144 GLN B NE2 1 
ATOM   2760 N  N   . ILE B 1 165 ? -47.98723 34.87929 -18.53081 1.000 60.14000  ? 145 ILE B N   1 
ATOM   2761 C  CA  . ILE B 1 165 ? -48.13491 36.01928 -17.63260 1.000 71.64000  ? 145 ILE B CA  1 
ATOM   2762 C  C   . ILE B 1 165 ? -47.91628 35.63929 -16.16486 1.000 65.82000  ? 145 ILE B C   1 
ATOM   2763 O  O   . ILE B 1 165 ? -47.28433 36.42449 -15.44534 1.000 70.55000  ? 145 ILE B O   1 
ATOM   2764 C  CB  . ILE B 1 165 ? -49.48903 36.71018 -17.88093 1.000 69.04000  ? 145 ILE B CB  1 
ATOM   2765 C  CG1 . ILE B 1 165 ? -49.36811 37.64811 -19.09038 1.000 65.73000  ? 145 ILE B CG1 1 
ATOM   2766 C  CG2 . ILE B 1 165 ? -49.94522 37.49645 -16.68195 1.000 70.22000  ? 145 ILE B CG2 1 
ATOM   2767 N  N   . PRO B 1 166 ? -48.36088 34.47207 -15.66282 1.000 66.99000  ? 146 PRO B N   1 
ATOM   2768 C  CA  . PRO B 1 166 ? -48.08219 34.17114 -14.24240 1.000 70.92000  ? 146 PRO B CA  1 
ATOM   2769 C  C   . PRO B 1 166 ? -46.59795 34.14468 -13.92861 1.000 75.21000  ? 146 PRO B C   1 
ATOM   2770 O  O   . PRO B 1 166 ? -46.16598 34.60089 -12.85620 1.000 72.51000  ? 146 PRO B O   1 
ATOM   2771 C  CB  . PRO B 1 166 ? -48.72115 32.78994 -14.02178 1.000 64.19000  ? 146 PRO B CB  1 
ATOM   2772 C  CG  . PRO B 1 166 ? -49.59099 32.54452 -15.15104 1.000 70.58000  ? 146 PRO B CG  1 
ATOM   2773 C  CD  . PRO B 1 166 ? -49.19268 33.42885 -16.29086 1.000 65.32000  ? 146 PRO B CD  1 
ATOM   2774 N  N   . ARG B 1 167 ? -45.79447 33.62314 -14.85123 1.000 75.88000  ? 147 ARG B N   1 
ATOM   2775 C  CA  . ARG B 1 167 ? -44.36337 33.59820 -14.60414 1.000 78.07000  ? 147 ARG B CA  1 
ATOM   2776 C  C   . ARG B 1 167 ? -43.73307 34.97275 -14.80436 1.000 72.47000  ? 147 ARG B C   1 
ATOM   2777 O  O   . ARG B 1 167 ? -42.84318 35.36486 -14.04142 1.000 78.00000  ? 147 ARG B O   1 
ATOM   2778 C  CB  . ARG B 1 167 ? -43.70424 32.57226 -15.50532 1.000 77.53000  ? 147 ARG B CB  1 
ATOM   2779 C  CG  . ARG B 1 167 ? -42.28825 32.34507 -15.13675 1.000 82.86000  ? 147 ARG B CG  1 
ATOM   2780 C  CD  . ARG B 1 167 ? -41.96076 30.90426 -15.36830 1.000 85.17000  ? 147 ARG B CD  1 
ATOM   2781 N  NE  . ARG B 1 167 ? -41.42559 30.72264 -16.70818 1.000 76.16000  ? 147 ARG B NE  1 
ATOM   2782 C  CZ  . ARG B 1 167 ? -40.22979 31.15452 -17.08296 1.000 83.35000  ? 147 ARG B CZ  1 
ATOM   2783 N  NH1 . ARG B 1 167 ? -39.41512 31.76655 -16.23360 1.000 85.37000  ? 147 ARG B NH1 1 
ATOM   2784 N  NH2 . ARG B 1 167 ? -39.84154 30.97185 -18.33984 1.000 88.26000  ? 147 ARG B NH2 1 
ATOM   2785 N  N   . ILE B 1 168 ? -44.18936 35.71943 -15.81151 1.000 74.84000  ? 148 ILE B N   1 
ATOM   2786 C  CA  . ILE B 1 168 ? -43.67325 37.06571 -16.03389 1.000 73.60000  ? 148 ILE B CA  1 
ATOM   2787 C  C   . ILE B 1 168 ? -44.01439 37.95837 -14.84871 1.000 75.85000  ? 148 ILE B C   1 
ATOM   2788 O  O   . ILE B 1 168 ? -43.14317 38.62844 -14.28108 1.000 73.45000  ? 148 ILE B O   1 
ATOM   2789 C  CB  . ILE B 1 168 ? -44.22368 37.65020 -17.35102 1.000 73.67000  ? 148 ILE B CB  1 
ATOM   2790 C  CG1 . ILE B 1 168 ? -43.49263 37.07679 -18.57306 1.000 71.78000  ? 148 ILE B CG1 1 
ATOM   2791 C  CG2 . ILE B 1 168 ? -44.13556 39.17940 -17.34518 1.000 72.23000  ? 148 ILE B CG2 1 
ATOM   2792 N  N   . ALA B 1 169 ? -45.29472 37.98113 -14.45924 1.000 74.99000  ? 149 ALA B N   1 
ATOM   2793 C  CA  . ALA B 1 169 ? -45.72994 38.81969 -13.34508 1.000 72.60000  ? 149 ALA B CA  1 
ATOM   2794 C  C   . ALA B 1 169 ? -44.98094 38.48797 -12.06417 1.000 79.84000  ? 149 ALA B C   1 
ATOM   2795 O  O   . ALA B 1 169 ? -44.74930 39.37403 -11.23543 1.000 80.67000  ? 149 ALA B O   1 
ATOM   2796 C  CB  . ALA B 1 169 ? -47.23714 38.66300 -13.12151 1.000 31.63000  ? 149 ALA B CB  1 
ATOM   2797 N  N   . ARG B 1 170 ? -44.61555 37.21746 -11.87869 1.000 81.84000  ? 150 ARG B N   1 
ATOM   2798 C  CA  . ARG B 1 170 ? -43.81463 36.82817 -10.72497 1.000 81.92000  ? 150 ARG B CA  1 
ATOM   2799 C  C   . ARG B 1 170 ? -42.49909 37.59650 -10.69333 1.000 79.37000  ? 150 ARG B C   1 
ATOM   2800 O  O   . ARG B 1 170 ? -42.15235 38.21112 -9.67943  1.000 80.36000  ? 150 ARG B O   1 
ATOM   2801 C  CB  . ARG B 1 170 ? -43.56055 35.32104 -10.76406 1.000 83.55000  ? 150 ARG B CB  1 
ATOM   2802 C  CG  . ARG B 1 170 ? -43.11903 34.71622 -9.45813  1.000 83.80000  ? 150 ARG B CG  1 
ATOM   2803 C  CD  . ARG B 1 170 ? -43.01548 33.20918 -9.57732  1.000 82.13000  ? 150 ARG B CD  1 
ATOM   2804 N  NE  . ARG B 1 170 ? -41.98775 32.67694 -8.69623  1.000 82.99000  ? 150 ARG B NE  1 
ATOM   2805 C  CZ  . ARG B 1 170 ? -42.12352 32.52742 -7.38501  1.000 80.85000  ? 150 ARG B CZ  1 
ATOM   2806 N  NH1 . ARG B 1 170 ? -43.24983 32.84672 -6.76003  1.000 84.43000  ? 150 ARG B NH1 1 
ATOM   2807 N  NH2 . ARG B 1 170 ? -41.10912 32.03210 -6.68498  1.000 79.99000  ? 150 ARG B NH2 1 
ATOM   2808 N  N   . GLU B 1 171 ? -41.75420 37.58692 -11.80465 1.000 79.15000  ? 151 GLU B N   1 
ATOM   2809 C  CA  . GLU B 1 171 ? -40.45273 38.24748 -11.79784 1.000 77.37000  ? 151 GLU B CA  1 
ATOM   2810 C  C   . GLU B 1 171 ? -40.58596 39.76232 -11.85037 1.000 79.16000  ? 151 GLU B C   1 
ATOM   2811 O  O   . GLU B 1 171 ? -39.71978 40.47325 -11.32951 1.000 77.48000  ? 151 GLU B O   1 
ATOM   2812 C  CB  . GLU B 1 171 ? -39.58890 37.74048 -12.95668 0.692 89.04000  ? 151 GLU B CB  1 
ATOM   2813 C  CG  . GLU B 1 171 ? -38.21971 38.42395 -13.08409 0.582 94.52000  ? 151 GLU B CG  1 
ATOM   2814 C  CD  . GLU B 1 171 ? -37.26759 38.07250 -11.94109 0.983 94.61000  ? 151 GLU B CD  1 
ATOM   2815 O  OE1 . GLU B 1 171 ? -37.45258 37.01071 -11.30756 1.000 89.74000  ? 151 GLU B OE1 1 
ATOM   2816 O  OE2 . GLU B 1 171 ? -36.32584 38.85586 -11.68752 1.000 99.18000  ? 151 GLU B OE2 1 
ATOM   2817 N  N   . LYS B 1 172 ? -41.65934 40.26655 -12.45832 1.000 81.80000  ? 152 LYS B N   1 
ATOM   2818 C  CA  . LYS B 1 172 ? -41.93928 41.69932 -12.43311 1.000 81.98000  ? 152 LYS B CA  1 
ATOM   2819 C  C   . LYS B 1 172 ? -42.05590 42.21364 -10.99912 1.000 83.26000  ? 152 LYS B C   1 
ATOM   2820 O  O   . LYS B 1 172 ? -41.51131 43.26955 -10.65548 1.000 82.65000  ? 152 LYS B O   1 
ATOM   2821 C  CB  . LYS B 1 172 ? -43.22606 41.97534 -13.21473 1.000 81.57000  ? 152 LYS B CB  1 
ATOM   2822 C  CG  . LYS B 1 172 ? -43.20543 43.18980 -14.10866 1.000 84.88000  ? 152 LYS B CG  1 
ATOM   2823 C  CD  . LYS B 1 172 ? -43.10197 42.82443 -15.58088 1.000 88.57000  ? 152 LYS B CD  1 
ATOM   2824 N  N   . ILE B 1 173 ? -42.77713 41.48208 -10.14564 1.000 78.52000  ? 153 ILE B N   1 
ATOM   2825 C  CA  . ILE B 1 173 ? -42.88019 41.87617 -8.74454  1.000 78.72000  ? 153 ILE B CA  1 
ATOM   2826 C  C   . ILE B 1 173 ? -41.50633 41.82493 -8.07713  1.000 80.69000  ? 153 ILE B C   1 
ATOM   2827 O  O   . ILE B 1 173 ? -41.14451 42.72062 -7.30065  1.000 77.43000  ? 153 ILE B O   1 
ATOM   2828 C  CB  . ILE B 1 173 ? -43.91694 40.99810 -8.01387  1.000 78.57000  ? 153 ILE B CB  1 
ATOM   2829 C  CG1 . ILE B 1 173 ? -45.33334 41.35210 -8.46025  1.000 76.44000  ? 153 ILE B CG1 1 
ATOM   2830 C  CG2 . ILE B 1 173 ? -43.78802 41.12842 -6.49878  1.000 76.60000  ? 153 ILE B CG2 1 
ATOM   2831 N  N   . ARG B 1 174 ? -40.70875 40.79313 -8.38417  1.000 81.98000  ? 154 ARG B N   1 
ATOM   2832 C  CA  . ARG B 1 174 ? -39.35693 40.71858 -7.83154  1.000 83.28000  ? 154 ARG B CA  1 
ATOM   2833 C  C   . ARG B 1 174 ? -38.51890 41.91235 -8.27678  1.000 82.95000  ? 154 ARG B C   1 
ATOM   2834 O  O   . ARG B 1 174 ? -37.85647 42.55955 -7.45501  1.000 83.37000  ? 154 ARG B O   1 
ATOM   2835 C  CB  . ARG B 1 174 ? -38.68180 39.40403 -8.23799  1.000 79.35000  ? 154 ARG B CB  1 
ATOM   2836 C  CG  . ARG B 1 174 ? -37.52761 38.97944 -7.33642  1.000 80.01000  ? 154 ARG B CG  1 
ATOM   2837 N  N   . GLY B 1 175 ? -38.56909 42.24776 -9.56540  1.000 84.01000  ? 155 GLY B N   1 
ATOM   2838 C  CA  . GLY B 1 175 ? -37.77789 43.36086 -10.05500 1.000 86.45000  ? 155 GLY B CA  1 
ATOM   2839 C  C   . GLY B 1 175 ? -38.28039 44.71853 -9.60853  1.000 81.90000  ? 155 GLY B C   1 
ATOM   2840 O  O   . GLY B 1 175 ? -37.48636 45.63900 -9.40945  1.000 81.57000  ? 155 GLY B O   1 
ATOM   2841 N  N   . LEU B 1 176 ? -39.59322 44.86869 -9.44375  1.000 81.62000  ? 156 LEU B N   1 
ATOM   2842 C  CA  . LEU B 1 176 ? -40.13516 46.17157 -9.06829  1.000 84.93000  ? 156 LEU B CA  1 
ATOM   2843 C  C   . LEU B 1 176 ? -39.71095 46.57973 -7.65420  1.000 87.02000  ? 156 LEU B C   1 
ATOM   2844 O  O   . LEU B 1 176 ? -39.31087 47.72964 -7.42819  1.000 89.15000  ? 156 LEU B O   1 
ATOM   2845 C  CB  . LEU B 1 176 ? -41.65977 46.15654 -9.20086  1.000 83.69000  ? 156 LEU B CB  1 
ATOM   2846 C  CG  . LEU B 1 176 ? -42.26104 46.69950 -10.49923 1.000 84.61000  ? 156 LEU B CG  1 
ATOM   2847 N  N   . THR B 1 177 ? -39.78361 45.65943 -6.69036  1.000 85.89000  ? 157 THR B N   1 
ATOM   2848 C  CA  . THR B 1 177 ? -39.49646 45.99440 -5.29729  1.000 85.31000  ? 157 THR B CA  1 
ATOM   2849 C  C   . THR B 1 177 ? -38.02197 45.88596 -4.93231  1.000 87.64000  ? 157 THR B C   1 
ATOM   2850 O  O   . THR B 1 177 ? -37.60199 46.50615 -3.95015  1.000 88.24000  ? 157 THR B O   1 
ATOM   2851 C  CB  . THR B 1 177 ? -40.31078 45.10560 -4.33445  1.000 82.88000  ? 157 THR B CB  1 
ATOM   2852 O  OG1 . THR B 1 177 ? -39.60559 43.88640 -4.06573  1.000 78.14000  ? 157 THR B OG1 1 
ATOM   2853 C  CG2 . THR B 1 177 ? -41.69797 44.78685 -4.88339  1.000 81.26000  ? 157 THR B CG2 1 
ATOM   2854 N  N   . GLU B 1 178 ? -37.23441 45.11690 -5.68530  1.000 87.40000  ? 158 GLU B N   1 
ATOM   2855 C  CA  . GLU B 1 178 ? -35.80593 45.01774 -5.40596  1.000 92.30000  ? 158 GLU B CA  1 
ATOM   2856 C  C   . GLU B 1 178 ? -35.04922 46.26307 -5.87106  1.000 96.81000  ? 158 GLU B C   1 
ATOM   2857 O  O   . GLU B 1 178 ? -34.20738 46.78674 -5.13264  1.000 96.29000  ? 158 GLU B O   1 
ATOM   2858 C  CB  . GLU B 1 178 ? -35.23293 43.75516 -6.06329  1.000 91.16000  ? 158 GLU B CB  1 
ATOM   2859 C  CG  . GLU B 1 178 ? -33.94056 43.23289 -5.45251  1.000 87.60000  ? 158 GLU B CG  1 
ATOM   2860 N  N   . TYR B 1 179 ? -35.35056 46.76792 -7.07203  1.000 85.88000  ? 159 TYR B N   1 
ATOM   2861 C  CA  . TYR B 1 179 ? -34.54459 47.80148 -7.71150  1.000 93.53000  ? 159 TYR B CA  1 
ATOM   2862 C  C   . TYR B 1 179 ? -35.24799 49.14194 -7.86847  1.000 94.25000  ? 159 TYR B C   1 
ATOM   2863 O  O   . TYR B 1 179 ? -34.58367 50.17958 -7.80451  1.000 94.07000  ? 159 TYR B O   1 
ATOM   2864 C  CB  . TYR B 1 179 ? -34.07594 47.31662 -9.09287  1.000 94.36000  ? 159 TYR B CB  1 
ATOM   2865 C  CG  . TYR B 1 179 ? -33.38902 45.97201 -9.01793  1.000 94.92000  ? 159 TYR B CG  1 
ATOM   2866 C  CD1 . TYR B 1 179 ? -32.14685 45.84122 -8.40265  1.000 97.82000  ? 159 TYR B CD1 1 
ATOM   2867 C  CD2 . TYR B 1 179 ? -33.99476 44.82629 -9.52321  1.000 97.70000  ? 159 TYR B CD2 1 
ATOM   2868 C  CE1 . TYR B 1 179 ? -31.51112 44.60516 -8.31036  1.000 99.89000  ? 159 TYR B CE1 1 
ATOM   2869 C  CE2 . TYR B 1 179 ? -33.37239 43.58298 -9.43423  1.000 97.99000  ? 159 TYR B CE2 1 
ATOM   2870 C  CZ  . TYR B 1 179 ? -32.13019 43.47804 -8.82565  1.000 101.05000 ? 159 TYR B CZ  1 
ATOM   2871 O  OH  . TYR B 1 179 ? -31.50611 42.24824 -8.73472  1.000 102.60000 ? 159 TYR B OH  1 
ATOM   2872 N  N   . PHE B 1 180 ? -36.56657 49.15763 -8.06972  1.000 93.18000  ? 160 PHE B N   1 
ATOM   2873 C  CA  . PHE B 1 180 ? -37.28245 50.39446 -8.35364  1.000 90.74000  ? 160 PHE B CA  1 
ATOM   2874 C  C   . PHE B 1 180 ? -38.07885 50.89937 -7.15424  1.000 88.39000  ? 160 PHE B C   1 
ATOM   2875 O  O   . PHE B 1 180 ? -39.02459 51.67083 -7.32847  1.000 89.11000  ? 160 PHE B O   1 
ATOM   2876 C  CB  . PHE B 1 180 ? -38.19429 50.22259 -9.57357  1.000 84.61000  ? 160 PHE B CB  1 
ATOM   2877 C  CG  . PHE B 1 180 ? -37.49821 49.64488 -10.79321 1.000 89.43000  ? 160 PHE B CG  1 
ATOM   2878 C  CD1 . PHE B 1 180 ? -37.38595 48.27359 -10.97026 1.000 88.65000  ? 160 PHE B CD1 1 
ATOM   2879 C  CD2 . PHE B 1 180 ? -36.96803 50.47801 -11.76960 1.000 88.60000  ? 160 PHE B CD2 1 
ATOM   2880 C  CE1 . PHE B 1 180 ? -36.74757 47.74627 -12.08703 1.000 81.13000  ? 160 PHE B CE1 1 
ATOM   2881 C  CE2 . PHE B 1 180 ? -36.33030 49.95494 -12.89045 1.000 89.33000  ? 160 PHE B CE2 1 
ATOM   2882 C  CZ  . PHE B 1 180 ? -36.21867 48.58915 -13.04684 1.000 86.93000  ? 160 PHE B CZ  1 
ATOM   2883 N  N   . GLY B 1 181 ? -37.72303 50.47316 -5.94448  1.000 92.93000  ? 161 GLY B N   1 
ATOM   2884 C  CA  . GLY B 1 181 ? -38.20159 51.13091 -4.73148  1.000 88.36000  ? 161 GLY B CA  1 
ATOM   2885 C  C   . GLY B 1 181 ? -39.69273 51.06126 -4.48128  1.000 89.61000  ? 161 GLY B C   1 
ATOM   2886 O  O   . GLY B 1 181 ? -40.28431 52.02127 -3.96672  1.000 84.17000  ? 161 GLY B O   1 
ATOM   2887 N  N   . PHE B 1 182 ? -40.31605 49.93922 -4.81564  1.000 88.81000  ? 162 PHE B N   1 
ATOM   2888 C  CA  . PHE B 1 182 ? -41.74917 49.76417 -4.61947  1.000 87.74000  ? 162 PHE B CA  1 
ATOM   2889 C  C   . PHE B 1 182 ? -41.99273 49.19284 -3.22792  1.000 85.69000  ? 162 PHE B C   1 
ATOM   2890 O  O   . PHE B 1 182 ? -41.71509 48.01638 -2.97416  1.000 84.78000  ? 162 PHE B O   1 
ATOM   2891 C  CB  . PHE B 1 182 ? -42.32006 48.85417 -5.70133  1.000 91.88000  ? 162 PHE B CB  1 
ATOM   2892 C  CG  . PHE B 1 182 ? -42.76910 49.59056 -6.93036  1.000 87.33000  ? 162 PHE B CG  1 
ATOM   2893 C  CD1 . PHE B 1 182 ? -41.84118 50.17100 -7.77972  1.000 91.56000  ? 162 PHE B CD1 1 
ATOM   2894 C  CD2 . PHE B 1 182 ? -44.11638 49.70430 -7.23678  1.000 85.74000  ? 162 PHE B CD2 1 
ATOM   2895 C  CE1 . PHE B 1 182 ? -42.24975 50.85612 -8.91613  1.000 87.93000  ? 162 PHE B CE1 1 
ATOM   2896 C  CE2 . PHE B 1 182 ? -44.53240 50.38747 -8.37040  1.000 84.59000  ? 162 PHE B CE2 1 
ATOM   2897 C  CZ  . PHE B 1 182 ? -43.59618 50.96426 -9.21011  1.000 81.88000  ? 162 PHE B CZ  1 
ATOM   2898 N  N   . SER B 1 183 ? -42.50950 50.02580 -2.32620  1.000 85.80000  ? 163 SER B N   1 
ATOM   2899 C  CA  . SER B 1 183 ? -42.84229 49.58877 -0.97490  1.000 84.11000  ? 163 SER B CA  1 
ATOM   2900 C  C   . SER B 1 183 ? -44.32709 49.29279 -0.79501  1.000 86.64000  ? 163 SER B C   1 
ATOM   2901 O  O   . SER B 1 183 ? -44.68165 48.31363 -0.13005  1.000 81.95000  ? 163 SER B O   1 
ATOM   2902 C  CB  . SER B 1 183 ? -42.39870 50.63834 0.05363   1.000 80.97000  ? 163 SER B CB  1 
ATOM   2903 O  OG  . SER B 1 183 ? -42.17195 51.89855 -0.54853  1.000 80.32000  ? 163 SER B OG  1 
ATOM   2904 N  N   . ASN B 1 184 ? -45.20579 50.10496 -1.37776  1.000 84.86000  ? 164 ASN B N   1 
ATOM   2905 C  CA  . ASN B 1 184 ? -46.63660 49.89369 -1.21839  1.000 83.35000  ? 164 ASN B CA  1 
ATOM   2906 C  C   . ASN B 1 184 ? -47.10709 48.84608 -2.22678  1.000 86.90000  ? 164 ASN B C   1 
ATOM   2907 O  O   . ASN B 1 184 ? -47.00739 49.09427 -3.43905  1.000 82.75000  ? 164 ASN B O   1 
ATOM   2908 C  CB  . ASN B 1 184 ? -47.40812 51.19575 -1.39929  1.000 78.14000  ? 164 ASN B CB  1 
ATOM   2909 C  CG  . ASN B 1 184 ? -48.85153 51.07573 -0.96903  1.000 86.86000  ? 164 ASN B CG  1 
ATOM   2910 O  OD1 . ASN B 1 184 ? -49.77436 51.53705 -1.64729  1.000 84.04000  ? 164 ASN B OD1 1 
ATOM   2911 N  ND2 . ASN B 1 184 ? -49.05532 50.45514 0.18138   1.000 99.05000  ? 164 ASN B ND2 1 
ATOM   2912 N  N   . PRO B 1 185 ? -47.61977 47.70658 -1.79148  1.000 85.64000  ? 165 PRO B N   1 
ATOM   2913 C  CA  . PRO B 1 185 ? -47.96785 46.63105 -2.72847  1.000 84.28000  ? 165 PRO B CA  1 
ATOM   2914 C  C   . PRO B 1 185 ? -49.27135 46.84957 -3.47851  1.000 82.30000  ? 165 PRO B C   1 
ATOM   2915 O  O   . PRO B 1 185 ? -49.66260 45.97102 -4.25209  1.000 76.95000  ? 165 PRO B O   1 
ATOM   2916 C  CB  . PRO B 1 185 ? -48.06657 45.38953 -1.82459  1.000 88.44000  ? 165 PRO B CB  1 
ATOM   2917 C  CG  . PRO B 1 185 ? -48.09454 45.90512 -0.39180  1.000 91.16000  ? 165 PRO B CG  1 
ATOM   2918 C  CD  . PRO B 1 185 ? -48.07595 47.40737 -0.42339  1.000 86.26000  ? 165 PRO B CD  1 
ATOM   2919 N  N   . GLU B 1 186 ? -49.98336 47.95469 -3.24897  1.000 79.58000  ? 166 GLU B N   1 
ATOM   2920 C  CA  . GLU B 1 186 ? -51.06863 48.29614 -4.15353  1.000 79.47000  ? 166 GLU B CA  1 
ATOM   2921 C  C   . GLU B 1 186 ? -50.52594 48.83670 -5.46612  1.000 81.79000  ? 166 GLU B C   1 
ATOM   2922 O  O   . GLU B 1 186 ? -51.24719 48.85820 -6.46993  1.000 83.49000  ? 166 GLU B O   1 
ATOM   2923 C  CB  . GLU B 1 186 ? -51.99269 49.33944 -3.53148  1.000 37.17000  ? 166 GLU B CB  1 
ATOM   2924 C  CG  . GLU B 1 186 ? -53.50257 48.94962 -3.47597  1.000 37.17000  ? 166 GLU B CG  1 
ATOM   2925 C  CD  . GLU B 1 186 ? -53.78721 47.89245 -2.38292  1.000 37.17000  ? 166 GLU B CD  1 
ATOM   2926 N  N   . ASP B 1 187 ? -49.26955 49.27828 -5.46887  1.000 77.52000  ? 167 ASP B N   1 
ATOM   2927 C  CA  . ASP B 1 187 ? -48.66947 49.80721 -6.68302  1.000 80.44000  ? 167 ASP B CA  1 
ATOM   2928 C  C   . ASP B 1 187 ? -48.51065 48.71482 -7.73782  1.000 83.78000  ? 167 ASP B C   1 
ATOM   2929 O  O   . ASP B 1 187 ? -48.77950 48.94559 -8.92480  1.000 78.74000  ? 167 ASP B O   1 
ATOM   2930 C  CB  . ASP B 1 187 ? -47.32495 50.46351 -6.35112  1.000 83.52000  ? 167 ASP B CB  1 
ATOM   2931 C  CG  . ASP B 1 187 ? -47.45151 51.60110 -5.33807  1.000 85.27000  ? 167 ASP B CG  1 
ATOM   2932 O  OD1 . ASP B 1 187 ? -48.59309 52.01459 -5.04326  1.000 81.45000  ? 167 ASP B OD1 1 
ATOM   2933 O  OD2 . ASP B 1 187 ? -46.40534 52.08024 -4.83816  1.000 92.19000  ? 167 ASP B OD2 1 
ATOM   2934 N  N   . TYR B 1 188 ? -48.09542 47.51404 -7.32662  1.000 78.58000  ? 168 TYR B N   1 
ATOM   2935 C  CA  . TYR B 1 188 ? -47.97943 46.37878 -8.23278  1.000 71.10000  ? 168 TYR B CA  1 
ATOM   2936 C  C   . TYR B 1 188 ? -49.13583 45.39225 -8.07026  1.000 73.92000  ? 168 TYR B C   1 
ATOM   2937 O  O   . TYR B 1 188 ? -48.98760 44.20158 -8.36533  1.000 74.12000  ? 168 TYR B O   1 
ATOM   2938 C  CB  . TYR B 1 188 ? -46.62253 45.68532 -8.05752  1.000 70.38000  ? 168 TYR B CB  1 
ATOM   2939 C  CG  . TYR B 1 188 ? -46.33774 45.11702 -6.68043  1.000 74.67000  ? 168 TYR B CG  1 
ATOM   2940 C  CD1 . TYR B 1 188 ? -46.83681 43.87945 -6.29926  1.000 74.10000  ? 168 TYR B CD1 1 
ATOM   2941 C  CD2 . TYR B 1 188 ? -45.54875 45.80743 -5.77242  1.000 82.86000  ? 168 TYR B CD2 1 
ATOM   2942 C  CE1 . TYR B 1 188 ? -46.58494 43.34953 -5.04961  1.000 80.02000  ? 168 TYR B CE1 1 
ATOM   2943 C  CE2 . TYR B 1 188 ? -45.28163 45.28372 -4.51535  1.000 82.63000  ? 168 TYR B CE2 1 
ATOM   2944 C  CZ  . TYR B 1 188 ? -45.80339 44.05256 -4.16080  1.000 83.88000  ? 168 TYR B CZ  1 
ATOM   2945 O  OH  . TYR B 1 188 ? -45.54497 43.51889 -2.91864  1.000 84.71000  ? 168 TYR B OH  1 
ATOM   2946 N  N   . ALA B 1 189 ? -50.30190 45.87968 -7.63576  1.000 70.46000  ? 169 ALA B N   1 
ATOM   2947 C  CA  . ALA B 1 189 ? -51.47286 45.01759 -7.51340  1.000 70.64000  ? 169 ALA B CA  1 
ATOM   2948 C  C   . ALA B 1 189 ? -51.86637 44.38289 -8.84589  1.000 70.26000  ? 169 ALA B C   1 
ATOM   2949 O  O   . ALA B 1 189 ? -52.43641 43.28463 -8.85453  1.000 70.23000  ? 169 ALA B O   1 
ATOM   2950 C  CB  . ALA B 1 189 ? -52.65175 45.80335 -6.93332  1.000 63.37000  ? 169 ALA B CB  1 
ATOM   2951 N  N   . TYR B 1 190 ? -51.58029 45.04816 -9.97510  1.000 68.86000  ? 170 TYR B N   1 
ATOM   2952 C  CA  . TYR B 1 190 ? -51.88127 44.45576 -11.27835 1.000 67.39000  ? 170 TYR B CA  1 
ATOM   2953 C  C   . TYR B 1 190 ? -51.15927 43.12466 -11.44795 1.000 72.91000  ? 170 TYR B C   1 
ATOM   2954 O  O   . TYR B 1 190 ? -51.76245 42.11314 -11.82815 1.000 70.24000  ? 170 TYR B O   1 
ATOM   2955 C  CB  . TYR B 1 190 ? -51.49790 45.41109 -12.42059 1.000 71.33000  ? 170 TYR B CB  1 
ATOM   2956 C  CG  . TYR B 1 190 ? -51.74763 44.82610 -13.81107 1.000 63.69000  ? 170 TYR B CG  1 
ATOM   2957 C  CD1 . TYR B 1 190 ? -52.97889 44.97436 -14.43009 1.000 64.50000  ? 170 TYR B CD1 1 
ATOM   2958 C  CD2 . TYR B 1 190 ? -50.76348 44.11697 -14.48973 1.000 66.85000  ? 170 TYR B CD2 1 
ATOM   2959 C  CE1 . TYR B 1 190 ? -53.22436 44.44976 -15.68873 1.000 66.24000  ? 170 TYR B CE1 1 
ATOM   2960 C  CE2 . TYR B 1 190 ? -51.00893 43.57345 -15.76486 1.000 64.65000  ? 170 TYR B CE2 1 
ATOM   2961 C  CZ  . TYR B 1 190 ? -52.24077 43.75171 -16.34943 1.000 68.35000  ? 170 TYR B CZ  1 
ATOM   2962 O  OH  . TYR B 1 190 ? -52.51426 43.22877 -17.59368 1.000 64.09000  ? 170 TYR B OH  1 
ATOM   2963 N  N   . PHE B 1 191 ? -49.85832 43.10830 -11.17081 1.000 72.97000  ? 171 PHE B N   1 
ATOM   2964 C  CA  . PHE B 1 191 ? -49.10124 41.87608 -11.30600 1.000 72.23000  ? 171 PHE B CA  1 
ATOM   2965 C  C   . PHE B 1 191 ? -49.42914 40.87678 -10.20811 1.000 74.69000  ? 171 PHE B C   1 
ATOM   2966 O  O   . PHE B 1 191 ? -49.31991 39.66912 -10.43478 1.000 73.01000  ? 171 PHE B O   1 
ATOM   2967 C  CB  . PHE B 1 191 ? -47.62174 42.22570 -11.36022 1.000 75.27000  ? 171 PHE B CB  1 
ATOM   2968 C  CG  . PHE B 1 191 ? -47.29971 43.20718 -12.45476 1.000 72.19000  ? 171 PHE B CG  1 
ATOM   2969 C  CD1 . PHE B 1 191 ? -47.25180 42.79975 -13.76522 1.000 70.27000  ? 171 PHE B CD1 1 
ATOM   2970 C  CD2 . PHE B 1 191 ? -47.09269 44.53583 -12.17673 1.000 73.93000  ? 171 PHE B CD2 1 
ATOM   2971 C  CE1 . PHE B 1 191 ? -46.98788 43.70211 -14.77770 1.000 77.09000  ? 171 PHE B CE1 1 
ATOM   2972 C  CE2 . PHE B 1 191 ? -46.82036 45.43808 -13.18276 1.000 74.69000  ? 171 PHE B CE2 1 
ATOM   2973 C  CZ  . PHE B 1 191 ? -46.77082 45.02483 -14.47551 1.000 75.44000  ? 171 PHE B CZ  1 
ATOM   2974 N  N   . THR B 1 192 ? -49.89912 41.34302 -9.05359  1.000 65.97000  ? 172 THR B N   1 
ATOM   2975 C  CA  . THR B 1 192 ? -50.33649 40.41022 -8.02507  1.000 68.34000  ? 172 THR B CA  1 
ATOM   2976 C  C   . THR B 1 192 ? -51.57833 39.65040 -8.47571  1.000 65.76000  ? 172 THR B C   1 
ATOM   2977 O  O   . THR B 1 192 ? -51.63543 38.42014 -8.36528  1.000 77.05000  ? 172 THR B O   1 
ATOM   2978 C  CB  . THR B 1 192 ? -50.56879 41.15101 -6.69999  1.000 68.72000  ? 172 THR B CB  1 
ATOM   2979 O  OG1 . THR B 1 192 ? -49.29960 41.41742 -6.10448  1.000 64.46000  ? 172 THR B OG1 1 
ATOM   2980 C  CG2 . THR B 1 192 ? -51.39843 40.31575 -5.72424  1.000 53.95000  ? 172 THR B CG2 1 
ATOM   2981 N  N   . GLU B 1 193 ? -52.57265 40.35563 -9.01438  1.000 62.53000  ? 173 GLU B N   1 
ATOM   2982 C  CA  . GLU B 1 193 ? -53.76153 39.66013 -9.50041  1.000 69.27000  ? 173 GLU B CA  1 
ATOM   2983 C  C   . GLU B 1 193 ? -53.42216 38.65907 -10.61464 1.000 70.12000  ? 173 GLU B C   1 
ATOM   2984 O  O   . GLU B 1 193 ? -53.95273 37.53806 -10.63359 1.000 68.80000  ? 173 GLU B O   1 
ATOM   2985 C  CB  . GLU B 1 193 ? -54.81288 40.66772 -9.97076  1.000 67.02000  ? 173 GLU B CB  1 
ATOM   2986 C  CG  . GLU B 1 193 ? -56.09376 40.01872 -10.50650 1.000 77.86000  ? 173 GLU B CG  1 
ATOM   2987 C  CD  . GLU B 1 193 ? -56.92504 39.32793 -9.43107  1.000 83.59000  ? 173 GLU B CD  1 
ATOM   2988 O  OE1 . GLU B 1 193 ? -57.73756 40.01289 -8.76584  1.000 91.42000  ? 173 GLU B OE1 1 
ATOM   2989 O  OE2 . GLU B 1 193 ? -56.76735 38.09710 -9.25242  1.000 89.21000  ? 173 GLU B OE2 1 
ATOM   2990 N  N   . HIS B 1 194 ? -52.52562 39.02726 -11.53876 1.000 65.42000  ? 174 HIS B N   1 
ATOM   2991 C  CA  . HIS B 1 194 ? -52.27681 38.14886 -12.68179 1.000 74.90000  ? 174 HIS B CA  1 
ATOM   2992 C  C   . HIS B 1 194 ? -51.32386 37.00975 -12.34992 1.000 71.14000  ? 174 HIS B C   1 
ATOM   2993 O  O   . HIS B 1 194 ? -51.30503 36.01374 -13.07937 1.000 69.97000  ? 174 HIS B O   1 
ATOM   2994 C  CB  . HIS B 1 194 ? -51.75395 38.94652 -13.89398 1.000 68.76000  ? 174 HIS B CB  1 
ATOM   2995 C  CG  . HIS B 1 194 ? -52.83828 39.62439 -14.67733 1.000 72.18000  ? 174 HIS B CG  1 
ATOM   2996 N  ND1 . HIS B 1 194 ? -53.12389 40.96886 -14.55125 1.000 68.23000  ? 174 HIS B ND1 1 
ATOM   2997 C  CD2 . HIS B 1 194 ? -53.72949 39.13595 -15.57463 1.000 77.74000  ? 174 HIS B CD2 1 
ATOM   2998 C  CE1 . HIS B 1 194 ? -54.13828 41.27880 -15.34002 1.000 80.13000  ? 174 HIS B CE1 1 
ATOM   2999 N  NE2 . HIS B 1 194 ? -54.52084 40.18621 -15.97802 1.000 72.83000  ? 174 HIS B NE2 1 
ATOM   3000 N  N   . GLU B 1 195 ? -50.54571 37.12874 -11.26794 1.000 68.99000  ? 175 GLU B N   1 
ATOM   3001 C  CA  . GLU B 1 195 ? -49.80891 35.97812 -10.75266 1.000 78.06000  ? 175 GLU B CA  1 
ATOM   3002 C  C   . GLU B 1 195 ? -50.70570 34.75078 -10.65473 1.000 68.39000  ? 175 GLU B C   1 
ATOM   3003 O  O   . GLU B 1 195 ? -50.28503 33.63775 -10.98125 1.000 67.19000  ? 175 GLU B O   1 
ATOM   3004 C  CB  . GLU B 1 195 ? -49.20302 36.31126 -9.38663  1.000 73.77000  ? 175 GLU B CB  1 
ATOM   3005 C  CG  . GLU B 1 195 ? -47.67946 36.38371 -9.35498  1.000 86.54000  ? 175 GLU B CG  1 
ATOM   3006 C  CD  . GLU B 1 195 ? -47.09701 36.09409 -7.96243  1.000 90.89000  ? 175 GLU B CD  1 
ATOM   3007 O  OE1 . GLU B 1 195 ? -47.21244 36.96594 -7.05939  1.000 87.87000  ? 175 GLU B OE1 1 
ATOM   3008 O  OE2 . GLU B 1 195 ? -46.54742 34.97504 -7.77403  1.000 82.80000  ? 175 GLU B OE2 1 
ATOM   3009 N  N   . GLU B 1 196 ? -51.95470 34.94081 -10.23892 1.000 62.68000  ? 176 GLU B N   1 
ATOM   3010 C  CA  . GLU B 1 196 ? -52.89979 33.85463 -10.03940 1.000 62.44000  ? 176 GLU B CA  1 
ATOM   3011 C  C   . GLU B 1 196 ? -54.00455 33.81158 -11.07751 1.000 59.87000  ? 176 GLU B C   1 
ATOM   3012 O  O   . GLU B 1 196 ? -54.50113 32.73328 -11.38106 1.000 59.08000  ? 176 GLU B O   1 
ATOM   3013 C  CB  . GLU B 1 196 ? -53.54549 33.96158 -8.65403  1.000 53.64000  ? 176 GLU B CB  1 
ATOM   3014 N  N   . ALA B 1 197 ? -54.43769 34.96850 -11.59077 1.000 66.43000  ? 177 ALA B N   1 
ATOM   3015 C  CA  . ALA B 1 197 ? -55.57012 35.00349 -12.51256 1.000 59.35000  ? 177 ALA B CA  1 
ATOM   3016 C  C   . ALA B 1 197 ? -55.27539 34.20699 -13.77929 1.000 60.36000  ? 177 ALA B C   1 
ATOM   3017 O  O   . ALA B 1 197 ? -56.12858 33.45201 -14.26385 1.000 61.08000  ? 177 ALA B O   1 
ATOM   3018 N  N   . ASP B 1 198 ? -54.06830 34.32929 -14.31231 1.000 61.40000  ? 178 ASP B N   1 
ATOM   3019 C  CA  . ASP B 1 198 ? -53.82974 33.78315 -15.63871 1.000 63.94000  ? 178 ASP B CA  1 
ATOM   3020 C  C   . ASP B 1 198 ? -53.37850 32.32978 -15.62244 1.000 66.24000  ? 178 ASP B C   1 
ATOM   3021 O  O   . ASP B 1 198 ? -53.27959 31.72185 -16.69281 1.000 58.32000  ? 178 ASP B O   1 
ATOM   3022 C  CB  . ASP B 1 198 ? -52.84431 34.67011 -16.39812 1.000 67.53000  ? 178 ASP B CB  1 
ATOM   3023 C  CG  . ASP B 1 198 ? -53.56877 35.72059 -17.26580 1.000 69.98000  ? 178 ASP B CG  1 
ATOM   3024 O  OD1 . ASP B 1 198 ? -54.78868 35.56183 -17.53067 1.000 70.14000  ? 178 ASP B OD1 1 
ATOM   3025 O  OD2 . ASP B 1 198 ? -52.91511 36.69349 -17.69422 1.000 74.79000  ? 178 ASP B OD2 1 
ATOM   3026 N  N   . VAL B 1 199 ? -53.16061 31.74479 -14.43726 1.000 62.71000  ? 179 VAL B N   1 
ATOM   3027 C  CA  . VAL B 1 199 ? -53.10939 30.28883 -14.33654 1.000 57.85000  ? 179 VAL B CA  1 
ATOM   3028 C  C   . VAL B 1 199 ? -54.45490 29.70247 -14.72971 1.000 60.40000  ? 179 VAL B C   1 
ATOM   3029 O  O   . VAL B 1 199 ? -54.53447 28.70245 -15.45882 1.000 58.38000  ? 179 VAL B O   1 
ATOM   3030 C  CB  . VAL B 1 199 ? -52.69698 29.86417 -12.91393 1.000 65.64000  ? 179 VAL B CB  1 
ATOM   3031 C  CG1 . VAL B 1 199 ? -52.79794 28.34666 -12.74958 1.000 56.77000  ? 179 VAL B CG1 1 
ATOM   3032 C  CG2 . VAL B 1 199 ? -51.29861 30.35008 -12.61893 1.000 52.03000  ? 179 VAL B CG2 1 
ATOM   3033 N  N   . ARG B 1 200 ? -55.53219 30.33762 -14.27186 1.000 55.39000  ? 180 ARG B N   1 
ATOM   3034 C  CA  . ARG B 1 200 ? -56.87299 29.87771 -14.59479 1.000 59.35000  ? 180 ARG B CA  1 
ATOM   3035 C  C   . ARG B 1 200 ? -57.21543 30.15766 -16.05131 1.000 58.90000  ? 180 ARG B C   1 
ATOM   3036 O  O   . ARG B 1 200 ? -57.83731 29.32650 -16.72234 1.000 56.60000  ? 180 ARG B O   1 
ATOM   3037 C  CB  . ARG B 1 200 ? -57.87746 30.54456 -13.65349 1.000 60.64000  ? 180 ARG B CB  1 
ATOM   3038 C  CG  . ARG B 1 200 ? -59.34937 30.34295 -13.98733 1.000 62.41000  ? 180 ARG B CG  1 
ATOM   3039 C  CD  . ARG B 1 200 ? -60.34045 30.77835 -12.86238 1.000 59.60000  ? 180 ARG B CD  1 
ATOM   3040 N  NE  . ARG B 1 200 ? -60.32529 32.20944 -12.53861 1.000 80.17000  ? 180 ARG B NE  1 
ATOM   3041 C  CZ  . ARG B 1 200 ? -59.46582 32.81039 -11.71458 1.000 79.70000  ? 180 ARG B CZ  1 
ATOM   3042 N  NH1 . ARG B 1 200 ? -58.55121 32.12905 -11.04637 1.000 83.97000  ? 180 ARG B NH1 1 
ATOM   3043 N  NH2 . ARG B 1 200 ? -59.53033 34.12997 -11.55303 1.000 68.71000  ? 180 ARG B NH2 1 
ATOM   3044 N  N   . HIS B 1 201 ? -56.82004 31.32515 -16.55416 1.000 60.56000  ? 181 HIS B N   1 
ATOM   3045 C  CA  . HIS B 1 201 ? -57.17918 31.71080 -17.91591 1.000 58.85000  ? 181 HIS B CA  1 
ATOM   3046 C  C   . HIS B 1 201 ? -56.47022 30.82188 -18.93611 1.000 56.89000  ? 181 HIS B C   1 
ATOM   3047 O  O   . HIS B 1 201 ? -57.10534 30.29512 -19.85800 1.000 55.80000  ? 181 HIS B O   1 
ATOM   3048 C  CB  . HIS B 1 201 ? -56.82677 33.17652 -18.15323 1.000 64.16000  ? 181 HIS B CB  1 
ATOM   3049 C  CG  . HIS B 1 201 ? -57.65820 34.14183 -17.37763 1.000 60.66000  ? 181 HIS B CG  1 
ATOM   3050 N  ND1 . HIS B 1 201 ? -57.30471 35.46590 -17.22391 1.000 62.28000  ? 181 HIS B ND1 1 
ATOM   3051 C  CD2 . HIS B 1 201 ? -58.84187 33.99204 -16.74210 1.000 58.91000  ? 181 HIS B CD2 1 
ATOM   3052 C  CE1 . HIS B 1 201 ? -58.22047 36.08155 -16.49987 1.000 68.23000  ? 181 HIS B CE1 1 
ATOM   3053 N  NE2 . HIS B 1 201 ? -59.15879 35.20678 -16.18363 1.000 64.09000  ? 181 HIS B NE2 1 
ATOM   3054 N  N   . ALA B 1 202 ? -55.14825 30.64163 -18.76502 1.000 60.59000  ? 182 ALA B N   1 
ATOM   3055 C  CA  . ALA B 1 202 ? -54.37402 29.68327 -19.55455 1.000 59.99000  ? 182 ALA B CA  1 
ATOM   3056 C  C   . ALA B 1 202 ? -55.02367 28.30040 -19.54656 1.000 58.03000  ? 182 ALA B C   1 
ATOM   3057 O  O   . ALA B 1 202 ? -55.25311 27.70937 -20.60404 1.000 62.89000  ? 182 ALA B O   1 
ATOM   3058 N  N   . ARG B 1 203 ? -55.36979 27.78592 -18.36218 1.000 54.24000  ? 183 ARG B N   1 
ATOM   3059 C  CA  . ARG B 1 203 ? -55.95547 26.45430 -18.28334 1.000 54.12000  ? 183 ARG B CA  1 
ATOM   3060 C  C   . ARG B 1 203 ? -57.31262 26.40579 -18.94783 1.000 56.97000  ? 183 ARG B C   1 
ATOM   3061 O  O   . ARG B 1 203 ? -57.61762 25.45485 -19.67265 1.000 64.92000  ? 183 ARG B O   1 
ATOM   3062 C  CB  . ARG B 1 203 ? -56.09339 26.00184 -16.82841 1.000 54.28000  ? 183 ARG B CB  1 
ATOM   3063 C  CG  . ARG B 1 203 ? -56.90476 24.70529 -16.66236 1.000 51.44000  ? 183 ARG B CG  1 
ATOM   3064 C  CD  . ARG B 1 203 ? -56.92519 24.24923 -15.19846 1.000 65.82000  ? 183 ARG B CD  1 
ATOM   3065 N  NE  . ARG B 1 203 ? -57.61945 25.18912 -14.32469 1.000 56.89000  ? 183 ARG B NE  1 
ATOM   3066 C  CZ  . ARG B 1 203 ? -58.93001 25.35479 -14.33677 1.000 60.40000  ? 183 ARG B CZ  1 
ATOM   3067 N  NH1 . ARG B 1 203 ? -59.71393 24.58628 -15.07872 1.000 58.16000  ? 183 ARG B NH1 1 
ATOM   3068 N  NH2 . ARG B 1 203 ? -59.46578 26.31515 -13.59393 1.000 61.53000  ? 183 ARG B NH2 1 
ATOM   3069 N  N   . GLU B 1 204 ? -58.15066 27.40548 -18.69227 1.000 59.94000  ? 184 GLU B N   1 
ATOM   3070 C  CA  . GLU B 1 204 ? -59.47259 27.41201 -19.30042 1.000 61.28000  ? 184 GLU B CA  1 
ATOM   3071 C  C   . GLU B 1 204 ? -59.38415 27.60442 -20.80302 1.000 53.82000  ? 184 GLU B C   1 
ATOM   3072 O  O   . GLU B 1 204 ? -60.21246 27.07441 -21.53710 1.000 59.88000  ? 184 GLU B O   1 
ATOM   3073 C  CB  . GLU B 1 204 ? -60.32620 28.50234 -18.66783 1.000 56.35000  ? 184 GLU B CB  1 
ATOM   3074 C  CG  . GLU B 1 204 ? -61.03013 28.03248 -17.37928 1.000 63.89000  ? 184 GLU B CG  1 
ATOM   3075 C  CD  . GLU B 1 204 ? -61.86519 29.12896 -16.72499 1.000 72.33000  ? 184 GLU B CD  1 
ATOM   3076 O  OE1 . GLU B 1 204 ? -61.86618 30.27243 -17.24086 1.000 67.27000  ? 184 GLU B OE1 1 
ATOM   3077 O  OE2 . GLU B 1 204 ? -62.52301 28.83795 -15.69674 1.000 74.94000  ? 184 GLU B OE2 1 
ATOM   3078 N  N   . GLU B 1 205 ? -58.37102 28.32426 -21.27720 1.000 56.36000  ? 185 GLU B N   1 
ATOM   3079 C  CA  . GLU B 1 205 ? -58.24292 28.56265 -22.70385 1.000 58.56000  ? 185 GLU B CA  1 
ATOM   3080 C  C   . GLU B 1 205 ? -57.75154 27.31861 -23.42622 1.000 57.34000  ? 185 GLU B C   1 
ATOM   3081 O  O   . GLU B 1 205 ? -58.18954 27.03284 -24.54791 1.000 58.45000  ? 185 GLU B O   1 
ATOM   3082 C  CB  . GLU B 1 205 ? -57.30619 29.73032 -22.94318 1.000 56.14000  ? 185 GLU B CB  1 
ATOM   3083 C  CG  . GLU B 1 205 ? -58.03506 31.02751 -22.95921 1.000 57.59000  ? 185 GLU B CG  1 
ATOM   3084 C  CD  . GLU B 1 205 ? -57.12041 32.16824 -22.71171 1.000 57.96000  ? 185 GLU B CD  1 
ATOM   3085 O  OE1 . GLU B 1 205 ? -55.92037 31.93066 -22.47087 1.000 63.84000  ? 185 GLU B OE1 1 
ATOM   3086 O  OE2 . GLU B 1 205 ? -57.61271 33.30277 -22.77162 1.000 62.97000  ? 185 GLU B OE2 1 
ATOM   3087 N  N   . LYS B 1 206 ? -56.84197 26.57016 -22.79403 1.000 61.29000  ? 186 LYS B N   1 
ATOM   3088 C  CA  . LYS B 1 206 ? -56.44282 25.28233 -23.33875 1.000 58.64000  ? 186 LYS B CA  1 
ATOM   3089 C  C   . LYS B 1 206 ? -57.66704 24.42036 -23.61816 1.000 60.47000  ? 186 LYS B C   1 
ATOM   3090 O  O   . LYS B 1 206 ? -57.82730 23.87949 -24.71974 1.000 62.42000  ? 186 LYS B O   1 
ATOM   3091 C  CB  . LYS B 1 206 ? -55.47603 24.59054 -22.38501 1.000 58.21000  ? 186 LYS B CB  1 
ATOM   3092 C  CG  . LYS B 1 206 ? -54.61032 23.53919 -23.03566 1.000 61.48000  ? 186 LYS B CG  1 
ATOM   3093 C  CD  . LYS B 1 206 ? -53.12968 23.72662 -22.72541 1.000 65.05000  ? 186 LYS B CD  1 
ATOM   3094 C  CE  . LYS B 1 206 ? -52.39705 22.39114 -22.64225 1.000 62.88000  ? 186 LYS B CE  1 
ATOM   3095 N  NZ  . LYS B 1 206 ? -51.03749 22.56086 -22.07326 1.000 66.05000  ? 186 LYS B NZ  1 
ATOM   3096 N  N   . ALA B 1 207 ? -58.57282 24.32388 -22.64642 1.000 58.10000  ? 187 ALA B N   1 
ATOM   3097 C  CA  . ALA B 1 207 ? -59.80951 23.57772 -22.86340 1.000 54.68000  ? 187 ALA B CA  1 
ATOM   3098 C  C   . ALA B 1 207 ? -60.60967 24.15060 -24.02487 1.000 56.91000  ? 187 ALA B C   1 
ATOM   3099 O  O   . ALA B 1 207 ? -61.27181 23.41501 -24.76871 1.000 63.35000  ? 187 ALA B O   1 
ATOM   3100 C  CB  . ALA B 1 207 ? -60.66422 23.59972 -21.59987 1.000 54.92000  ? 187 ALA B CB  1 
ATOM   3101 N  N   . LEU B 1 208 ? -60.60537 25.47353 -24.15671 1.000 56.54000  ? 188 LEU B N   1 
ATOM   3102 C  CA  . LEU B 1 208 ? -61.45148 26.11851 -25.15027 1.000 60.02000  ? 188 LEU B CA  1 
ATOM   3103 C  C   . LEU B 1 208 ? -60.98441 25.76841 -26.55625 1.000 59.54000  ? 188 LEU B C   1 
ATOM   3104 O  O   . LEU B 1 208 ? -61.80463 25.51846 -27.45166 1.000 61.38000  ? 188 LEU B O   1 
ATOM   3105 C  CB  . LEU B 1 208 ? -61.44485 27.62793 -24.92758 1.000 59.18000  ? 188 LEU B CB  1 
ATOM   3106 C  CG  . LEU B 1 208 ? -62.46160 28.23937 -23.96274 1.000 57.66000  ? 188 LEU B CG  1 
ATOM   3107 C  CD1 . LEU B 1 208 ? -62.10790 29.68879 -23.73717 1.000 52.72000  ? 188 LEU B CD1 1 
ATOM   3108 C  CD2 . LEU B 1 208 ? -63.87637 28.11636 -24.52384 1.000 59.26000  ? 188 LEU B CD2 1 
ATOM   3109 N  N   . ILE B 1 209 ? -59.66351 25.71141 -26.74406 1.000 52.86000  ? 189 ILE B N   1 
ATOM   3110 C  CA  . ILE B 1 209 ? -59.09318 25.29166 -28.01572 1.000 61.69000  ? 189 ILE B CA  1 
ATOM   3111 C  C   . ILE B 1 209 ? -59.63487 23.92580 -28.41002 1.000 60.17000  ? 189 ILE B C   1 
ATOM   3112 O  O   . ILE B 1 209 ? -60.24198 23.77116 -29.46818 1.000 64.64000  ? 189 ILE B O   1 
ATOM   3113 C  CB  . ILE B 1 209 ? -57.55608 25.31737 -27.95179 1.000 58.43000  ? 189 ILE B CB  1 
ATOM   3114 C  CG1 . ILE B 1 209 ? -57.05901 26.76749 -28.03920 1.000 58.98000  ? 189 ILE B CG1 1 
ATOM   3115 C  CG2 . ILE B 1 209 ? -56.97696 24.50615 -29.05632 1.000 60.18000  ? 189 ILE B CG2 1 
ATOM   3116 C  CD1 . ILE B 1 209 ? -55.70205 26.99871 -27.50015 1.000 53.96000  ? 189 ILE B CD1 1 
ATOM   3117 N  N   . GLU B 1 210 ? -59.47770 22.93359 -27.54193 1.000 66.98000  ? 190 GLU B N   1 
ATOM   3118 C  CA  . GLU B 1 210 ? -60.05869 21.61830 -27.79193 1.000 65.32000  ? 190 GLU B CA  1 
ATOM   3119 C  C   . GLU B 1 210 ? -61.52849 21.70459 -28.17442 1.000 65.25000  ? 190 GLU B C   1 
ATOM   3120 O  O   . GLU B 1 210 ? -61.93034 21.20412 -29.21884 1.000 69.70000  ? 190 GLU B O   1 
ATOM   3121 C  CB  . GLU B 1 210 ? -59.90583 20.74283 -26.55294 1.000 70.62000  ? 190 GLU B CB  1 
ATOM   3122 C  CG  . GLU B 1 210 ? -58.54180 20.16410 -26.35209 1.000 80.77000  ? 190 GLU B CG  1 
ATOM   3123 C  CD  . GLU B 1 210 ? -58.60198 18.67600 -26.22830 1.000 92.33000  ? 190 GLU B CD  1 
ATOM   3124 O  OE1 . GLU B 1 210 ? -59.72679 18.15083 -26.09642 1.000 105.48000 ? 190 GLU B OE1 1 
ATOM   3125 O  OE2 . GLU B 1 210 ? -57.53404 18.03163 -26.26977 1.000 103.33000 ? 190 GLU B OE2 1 
ATOM   3126 N  N   . MET B 1 211 ? -62.35361 22.30721 -27.31391 1.000 65.23000  ? 191 MET B N   1 
ATOM   3127 C  CA  . MET B 1 211 ? -63.79923 22.33927 -27.54029 1.000 63.78000  ? 191 MET B CA  1 
ATOM   3128 C  C   . MET B 1 211 ? -64.15281 22.88104 -28.91286 1.000 59.03000  ? 191 MET B C   1 
ATOM   3129 O  O   . MET B 1 211 ? -65.14060 22.45262 -29.51733 1.000 57.65000  ? 191 MET B O   1 
ATOM   3130 C  CB  . MET B 1 211 ? -64.49411 23.21844 -26.49939 1.000 65.86000  ? 191 MET B CB  1 
ATOM   3131 C  CG  . MET B 1 211 ? -64.96889 22.56874 -25.20904 1.000 70.09000  ? 191 MET B CG  1 
ATOM   3132 S  SD  . MET B 1 211 ? -65.70504 23.84720 -24.13138 1.000 64.70000  ? 191 MET B SD  1 
ATOM   3133 C  CE  . MET B 1 211 ? -64.19791 24.63588 -23.61512 1.000 62.39000  ? 191 MET B CE  1 
ATOM   3134 N  N   . LEU B 1 212 ? -63.39676 23.86702 -29.39674 1.000 58.56000  ? 192 LEU B N   1 
ATOM   3135 C  CA  . LEU B 1 212 ? -63.77367 24.61817 -30.59234 1.000 63.76000  ? 192 LEU B CA  1 
ATOM   3136 C  C   . LEU B 1 212 ? -62.97018 24.23005 -31.83835 1.000 66.17000  ? 192 LEU B C   1 
ATOM   3137 O  O   . LEU B 1 212 ? -63.18181 24.82291 -32.90407 1.000 62.57000  ? 192 LEU B O   1 
ATOM   3138 C  CB  . LEU B 1 212 ? -63.62809 26.12404 -30.32759 1.000 54.66000  ? 192 LEU B CB  1 
ATOM   3139 C  CG  . LEU B 1 212 ? -64.47128 26.76158 -29.21245 1.000 58.43000  ? 192 LEU B CG  1 
ATOM   3140 C  CD1 . LEU B 1 212 ? -63.95189 28.13892 -28.88219 1.000 59.70000  ? 192 LEU B CD1 1 
ATOM   3141 C  CD2 . LEU B 1 212 ? -65.94429 26.82152 -29.53490 1.000 46.91000  ? 192 LEU B CD2 1 
ATOM   3142 N  N   . LEU B 1 213 ? -62.04324 23.27264 -31.71843 1.000 63.98000  ? 193 LEU B N   1 
ATOM   3143 C  CA  . LEU B 1 213 ? -61.27958 22.78211 -32.85713 1.000 63.77000  ? 193 LEU B CA  1 
ATOM   3144 C  C   . LEU B 1 213 ? -62.21258 22.27521 -33.94648 1.000 64.97000  ? 193 LEU B C   1 
ATOM   3145 O  O   . LEU B 1 213 ? -63.11115 21.47142 -33.69478 1.000 65.72000  ? 193 LEU B O   1 
ATOM   3146 C  CB  . LEU B 1 213 ? -60.33632 21.66763 -32.41230 1.000 65.79000  ? 193 LEU B CB  1 
ATOM   3147 C  CG  . LEU B 1 213 ? -59.13662 21.26968 -33.27983 1.000 65.68000  ? 193 LEU B CG  1 
ATOM   3148 C  CD1 . LEU B 1 213 ? -58.01971 22.32174 -33.24664 1.000 54.58000  ? 193 LEU B CD1 1 
ATOM   3149 C  CD2 . LEU B 1 213 ? -58.60870 19.91870 -32.82388 1.000 60.22000  ? 193 LEU B CD2 1 
ATOM   3150 N  N   . LYS B 1 214 ? -62.01196 22.77413 -35.15998 1.000 64.06000  ? 194 LYS B N   1 
ATOM   3151 C  CA  . LYS B 1 214 ? -62.78470 22.34631 -36.31801 1.000 73.60000  ? 194 LYS B CA  1 
ATOM   3152 C  C   . LYS B 1 214 ? -61.81983 22.06409 -37.47341 1.000 71.34000  ? 194 LYS B C   1 
ATOM   3153 O  O   . LYS B 1 214 ? -61.90023 22.68404 -38.52932 1.000 82.44000  ? 194 LYS B O   1 
ATOM   3154 C  CB  . LYS B 1 214 ? -63.83756 23.40130 -36.68091 1.000 71.08000  ? 194 LYS B CB  1 
ATOM   3155 C  CG  . LYS B 1 214 ? -65.21260 23.22047 -36.00625 1.000 64.53000  ? 194 LYS B CG  1 
ATOM   3156 N  N   . ASP B 1 215 ? -60.87798 21.13215 -37.24986 1.000 72.30000  ? 195 ASP B N   1 
ATOM   3157 C  CA  . ASP B 1 215 ? -59.83683 20.72833 -38.20838 1.000 76.94000  ? 195 ASP B CA  1 
ATOM   3158 C  C   . ASP B 1 215 ? -58.82934 21.84849 -38.51164 1.000 76.42000  ? 195 ASP B C   1 
ATOM   3159 O  O   . ASP B 1 215 ? -58.09629 21.79481 -39.51034 1.000 66.20000  ? 195 ASP B O   1 
ATOM   3160 C  CB  . ASP B 1 215 ? -60.45350 20.17593 -39.51303 1.000 77.98000  ? 195 ASP B CB  1 
ATOM   3161 C  CG  . ASP B 1 215 ? -59.39670 19.62462 -40.49343 1.000 84.72000  ? 195 ASP B CG  1 
ATOM   3162 O  OD1 . ASP B 1 215 ? -58.34864 19.12530 -40.01319 1.000 86.28000  ? 195 ASP B OD1 1 
ATOM   3163 O  OD2 . ASP B 1 215 ? -59.60372 19.70234 -41.73619 1.000 74.53000  ? 195 ASP B OD2 1 
ATOM   3164 N  N   . ASP B 1 216 ? -58.71544 22.84138 -37.64410 1.000 68.01000  ? 196 ASP B N   1 
ATOM   3165 C  CA  . ASP B 1 216 ? -57.86703 24.00106 -37.89822 1.000 69.10000  ? 196 ASP B CA  1 
ATOM   3166 C  C   . ASP B 1 216 ? -56.64502 24.04885 -36.97717 1.000 67.57000  ? 196 ASP B C   1 
ATOM   3167 O  O   . ASP B 1 216 ? -56.20898 25.12439 -36.54693 1.000 65.21000  ? 196 ASP B O   1 
ATOM   3168 C  CB  . ASP B 1 216 ? -58.68473 25.28028 -37.77389 1.000 68.80000  ? 196 ASP B CB  1 
ATOM   3169 C  CG  . ASP B 1 216 ? -59.72596 25.19804 -36.67371 1.000 72.01000  ? 196 ASP B CG  1 
ATOM   3170 O  OD1 . ASP B 1 216 ? -60.60393 26.09026 -36.62952 1.000 63.52000  ? 196 ASP B OD1 1 
ATOM   3171 O  OD2 . ASP B 1 216 ? -59.65510 24.25066 -35.85031 1.000 68.22000  ? 196 ASP B OD2 1 
ATOM   3172 N  N   . ALA B 1 217 ? -56.06827 22.87700 -36.69007 1.000 60.12000  ? 197 ALA B N   1 
ATOM   3173 C  CA  . ALA B 1 217 ? -54.82882 22.81730 -35.92094 1.000 58.96000  ? 197 ALA B CA  1 
ATOM   3174 C  C   . ALA B 1 217 ? -53.75978 23.72415 -36.50447 1.000 59.80000  ? 197 ALA B C   1 
ATOM   3175 O  O   . ALA B 1 217 ? -52.95744 24.30880 -35.76517 1.000 64.44000  ? 197 ALA B O   1 
ATOM   3176 C  CB  . ALA B 1 217 ? -54.31113 21.38391 -35.86133 1.000 57.66000  ? 197 ALA B CB  1 
ATOM   3177 N  N   . ASP B 1 218 ? -53.73005 23.84843 -37.83760 1.000 64.10000  ? 198 ASP B N   1 
ATOM   3178 C  CA  . ASP B 1 218 ? -52.69063 24.63286 -38.50444 1.000 68.43000  ? 198 ASP B CA  1 
ATOM   3179 C  C   . ASP B 1 218 ? -52.83739 26.12327 -38.18881 1.000 60.25000  ? 198 ASP B C   1 
ATOM   3180 O  O   . ASP B 1 218 ? -51.84728 26.81133 -37.88288 1.000 51.10000  ? 198 ASP B O   1 
ATOM   3181 C  CB  . ASP B 1 218 ? -52.71584 24.35355 -40.02661 1.000 65.19000  ? 198 ASP B CB  1 
ATOM   3182 C  CG  . ASP B 1 218 ? -54.08057 24.67828 -40.69691 1.000 80.95000  ? 198 ASP B CG  1 
ATOM   3183 O  OD1 . ASP B 1 218 ? -55.14569 24.22556 -40.21239 1.000 75.51000  ? 198 ASP B OD1 1 
ATOM   3184 O  OD2 . ASP B 1 218 ? -54.09261 25.37097 -41.74397 1.000 89.69000  ? 198 ASP B OD2 1 
ATOM   3185 N  N   . LYS B 1 219 ? -54.07582 26.62210 -38.23763 1.000 62.42000  ? 199 LYS B N   1 
ATOM   3186 C  CA  . LYS B 1 219 ? -54.35813 27.99736 -37.84723 1.000 63.73000  ? 199 LYS B CA  1 
ATOM   3187 C  C   . LYS B 1 219 ? -53.99125 28.24673 -36.38802 1.000 65.67000  ? 199 LYS B C   1 
ATOM   3188 O  O   . LYS B 1 219 ? -53.40670 29.28971 -36.05771 1.000 64.95000  ? 199 LYS B O   1 
ATOM   3189 C  CB  . LYS B 1 219 ? -55.83193 28.30445 -38.11623 1.000 64.00000  ? 199 LYS B CB  1 
ATOM   3190 C  CG  . LYS B 1 219 ? -56.15463 28.56393 -39.60829 1.000 63.57000  ? 199 LYS B CG  1 
ATOM   3191 N  N   . VAL B 1 220 ? -54.29350 27.28303 -35.50517 1.000 61.76000  ? 200 VAL B N   1 
ATOM   3192 C  CA  . VAL B 1 220 ? -53.94112 27.39511 -34.08628 1.000 56.92000  ? 200 VAL B CA  1 
ATOM   3193 C  C   . VAL B 1 220 ? -52.45494 27.70998 -33.93209 1.000 61.06000  ? 200 VAL B C   1 
ATOM   3194 O  O   . VAL B 1 220 ? -52.06724 28.69684 -33.29839 1.000 57.59000  ? 200 VAL B O   1 
ATOM   3195 C  CB  . VAL B 1 220 ? -54.31892 26.10366 -33.33929 1.000 57.19000  ? 200 VAL B CB  1 
ATOM   3196 C  CG1 . VAL B 1 220 ? -53.58699 26.00893 -32.01997 1.000 53.75000  ? 200 VAL B CG1 1 
ATOM   3197 C  CG2 . VAL B 1 220 ? -55.80757 26.01383 -33.13092 1.000 55.84000  ? 200 VAL B CG2 1 
ATOM   3198 N  N   . LEU B 1 221 ? -51.59631 26.87496 -34.52622 1.000 61.62000  ? 201 LEU B N   1 
ATOM   3199 C  CA  . LEU B 1 221 ? -50.14858 27.09124 -34.41940 1.000 59.59000  ? 201 LEU B CA  1 
ATOM   3200 C  C   . LEU B 1 221 ? -49.69308 28.33023 -35.19322 1.000 65.01000  ? 201 LEU B C   1 
ATOM   3201 O  O   . LEU B 1 221 ? -48.72317 28.98758 -34.79228 1.000 63.42000  ? 201 LEU B O   1 
ATOM   3202 C  CB  . LEU B 1 221 ? -49.41191 25.86398 -34.93938 1.000 60.56000  ? 201 LEU B CB  1 
ATOM   3203 C  CG  . LEU B 1 221 ? -49.78030 24.52463 -34.30986 1.000 70.16000  ? 201 LEU B CG  1 
ATOM   3204 C  CD1 . LEU B 1 221 ? -48.71767 23.50037 -34.63996 1.000 70.28000  ? 201 LEU B CD1 1 
ATOM   3205 C  CD2 . LEU B 1 221 ? -49.94679 24.65461 -32.78683 1.000 63.13000  ? 201 LEU B CD2 1 
ATOM   3206 N  N   . GLU B 1 222 ? -50.35935 28.63444 -36.31762 1.000 63.10000  ? 202 GLU B N   1 
ATOM   3207 C  CA  . GLU B 1 222 ? -50.09985 29.87294 -37.04808 1.000 69.35000  ? 202 GLU B CA  1 
ATOM   3208 C  C   . GLU B 1 222 ? -50.34992 31.08893 -36.16305 1.000 72.94000  ? 202 GLU B C   1 
ATOM   3209 O  O   . GLU B 1 222 ? -49.52809 32.01252 -36.11999 1.000 69.83000  ? 202 GLU B O   1 
ATOM   3210 C  CB  . GLU B 1 222 ? -50.97355 29.93030 -38.31540 1.000 65.93000  ? 202 GLU B CB  1 
ATOM   3211 C  CG  . GLU B 1 222 ? -50.40296 30.76001 -39.48078 1.000 79.12000  ? 202 GLU B CG  1 
ATOM   3212 C  CD  . GLU B 1 222 ? -51.43275 31.06149 -40.59868 1.000 76.48000  ? 202 GLU B CD  1 
ATOM   3213 O  OE1 . GLU B 1 222 ? -52.17874 30.13049 -40.99763 1.000 69.43000  ? 202 GLU B OE1 1 
ATOM   3214 O  OE2 . GLU B 1 222 ? -51.47837 32.22674 -41.08086 1.000 74.77000  ? 202 GLU B OE2 1 
ATOM   3215 N  N   . ALA B 1 223 ? -51.47661 31.09897 -35.43833 1.000 66.25000  ? 203 ALA B N   1 
ATOM   3216 C  CA  . ALA B 1 223 ? -51.75389 32.18901 -34.50750 1.000 65.19000  ? 203 ALA B CA  1 
ATOM   3217 C  C   . ALA B 1 223 ? -50.65236 32.31310 -33.46878 1.000 60.93000  ? 203 ALA B C   1 
ATOM   3218 O  O   . ALA B 1 223 ? -50.17932 33.41434 -33.17484 1.000 66.94000  ? 203 ALA B O   1 
ATOM   3219 C  CB  . ALA B 1 223 ? -53.10701 31.96768 -33.82748 1.000 67.01000  ? 203 ALA B CB  1 
ATOM   3220 N  N   . SER B 1 224 ? -50.24320 31.18205 -32.89251 1.000 66.14000  ? 204 SER B N   1 
ATOM   3221 C  CA  . SER B 1 224 ? -49.18695 31.17803 -31.89253 1.000 59.58000  ? 204 SER B CA  1 
ATOM   3222 C  C   . SER B 1 224 ? -47.93167 31.84549 -32.42146 1.000 64.12000  ? 204 SER B C   1 
ATOM   3223 O  O   . SER B 1 224 ? -47.27224 32.61120 -31.71078 1.000 61.57000  ? 204 SER B O   1 
ATOM   3224 C  CB  . SER B 1 224 ? -48.89767 29.73980 -31.48332 1.000 60.48000  ? 204 SER B CB  1 
ATOM   3225 O  OG  . SER B 1 224 ? -47.93488 29.68340 -30.44822 1.000 70.72000  ? 204 SER B OG  1 
ATOM   3226 N  N   . GLN B 1 225 ? -47.60341 31.57573 -33.68792 1.000 76.91000  ? 205 GLN B N   1 
ATOM   3227 C  CA  . GLN B 1 225 ? -46.41066 32.13735 -34.31139 1.000 69.29000  ? 205 GLN B CA  1 
ATOM   3228 C  C   . GLN B 1 225 ? -46.45254 33.65818 -34.31689 1.000 69.35000  ? 205 GLN B C   1 
ATOM   3229 O  O   . GLN B 1 225 ? -45.52107 34.32933 -33.84963 1.000 66.27000  ? 205 GLN B O   1 
ATOM   3230 C  CB  . GLN B 1 225 ? -46.29725 31.59752 -35.73571 1.000 72.96000  ? 205 GLN B CB  1 
ATOM   3231 C  CG  . GLN B 1 225 ? -45.99441 30.11500 -35.81503 1.000 76.18000  ? 205 GLN B CG  1 
ATOM   3232 C  CD  . GLN B 1 225 ? -44.52712 29.80800 -35.58322 1.000 82.63000  ? 205 GLN B CD  1 
ATOM   3233 O  OE1 . GLN B 1 225 ? -43.88947 30.36046 -34.67200 1.000 76.19000  ? 205 GLN B OE1 1 
ATOM   3234 N  NE2 . GLN B 1 225 ? -43.97977 28.91590 -36.40520 1.000 86.59000  ? 205 GLN B NE2 1 
ATOM   3235 N  N   . GLU B 1 226 ? -47.53547 34.21788 -34.84722 1.000 65.35000  ? 206 GLU B N   1 
ATOM   3236 C  CA  . GLU B 1 226 ? -47.64121 35.66738 -34.96365 1.000 64.52000  ? 206 GLU B CA  1 
ATOM   3237 C  C   . GLU B 1 226 ? -47.59775 36.33575 -33.59392 1.000 69.23000  ? 206 GLU B C   1 
ATOM   3238 O  O   . GLU B 1 226 ? -46.84959 37.29746 -33.39061 1.000 71.21000  ? 206 GLU B O   1 
ATOM   3239 C  CB  . GLU B 1 226 ? -48.91843 36.03014 -35.73055 1.000 68.47000  ? 206 GLU B CB  1 
ATOM   3240 C  CG  . GLU B 1 226 ? -49.04633 35.27054 -37.05701 1.000 64.03000  ? 206 GLU B CG  1 
ATOM   3241 C  CD  . GLU B 1 226 ? -49.86986 35.98838 -38.10555 1.000 73.73000  ? 206 GLU B CD  1 
ATOM   3242 O  OE1 . GLU B 1 226 ? -50.59615 36.93961 -37.77604 1.000 71.20000  ? 206 GLU B OE1 1 
ATOM   3243 O  OE2 . GLU B 1 226 ? -49.78834 35.59644 -39.28933 1.000 76.70000  ? 206 GLU B OE2 1 
ATOM   3244 N  N   . VAL B 1 227 ? -48.37763 35.83028 -32.63199 1.000 64.03000  ? 207 VAL B N   1 
ATOM   3245 C  CA  . VAL B 1 227 ? -48.47254 36.50829 -31.34194 1.000 65.98000  ? 207 VAL B CA  1 
ATOM   3246 C  C   . VAL B 1 227 ? -47.12790 36.48604 -30.62590 1.000 66.09000  ? 207 VAL B C   1 
ATOM   3247 O  O   . VAL B 1 227 ? -46.64884 37.52051 -30.14805 1.000 65.49000  ? 207 VAL B O   1 
ATOM   3248 C  CB  . VAL B 1 227 ? -49.58757 35.89366 -30.47791 1.000 66.66000  ? 207 VAL B CB  1 
ATOM   3249 C  CG1 . VAL B 1 227 ? -49.42752 36.32127 -29.03158 1.000 62.89000  ? 207 VAL B CG1 1 
ATOM   3250 C  CG2 . VAL B 1 227 ? -50.92362 36.33207 -30.98152 1.000 70.65000  ? 207 VAL B CG2 1 
ATOM   3251 N  N   . THR B 1 228 ? -46.48660 35.31593 -30.56468 1.000 64.82000  ? 208 THR B N   1 
ATOM   3252 C  CA  . THR B 1 228 ? -45.17761 35.23248 -29.92534 1.000 65.31000  ? 208 THR B CA  1 
ATOM   3253 C  C   . THR B 1 228 ? -44.21420 36.24548 -30.52908 1.000 69.39000  ? 208 THR B C   1 
ATOM   3254 O  O   . THR B 1 228 ? -43.52882 36.97364 -29.80047 1.000 64.66000  ? 208 THR B O   1 
ATOM   3255 C  CB  . THR B 1 228 ? -44.62184 33.81183 -30.03284 1.000 62.61000  ? 208 THR B CB  1 
ATOM   3256 O  OG1 . THR B 1 228 ? -45.00195 33.23234 -31.28367 1.000 70.46000  ? 208 THR B OG1 1 
ATOM   3257 C  CG2 . THR B 1 228 ? -45.15439 32.93346 -28.90092 1.000 66.56000  ? 208 THR B CG2 1 
ATOM   3258 N  N   . GLN B 1 229 ? -44.19208 36.34676 -31.86214 1.000 71.45000  ? 209 GLN B N   1 
ATOM   3259 C  CA  . GLN B 1 229 ? -43.33197 37.32670 -32.51346 1.000 71.52000  ? 209 GLN B CA  1 
ATOM   3260 C  C   . GLN B 1 229 ? -43.85055 38.74280 -32.31294 1.000 63.96000  ? 209 GLN B C   1 
ATOM   3261 O  O   . GLN B 1 229 ? -43.08522 39.63816 -31.94436 1.000 65.93000  ? 209 GLN B O   1 
ATOM   3262 C  CB  . GLN B 1 229 ? -43.19177 37.01556 -34.00847 1.000 71.20000  ? 209 GLN B CB  1 
ATOM   3263 C  CG  . GLN B 1 229 ? -42.34921 38.05176 -34.76258 1.000 64.47000  ? 209 GLN B CG  1 
ATOM   3264 C  CD  . GLN B 1 229 ? -40.96105 38.27501 -34.14646 1.000 76.51000  ? 209 GLN B CD  1 
ATOM   3265 O  OE1 . GLN B 1 229 ? -40.24982 37.32059 -33.79200 1.000 76.28000  ? 209 GLN B OE1 1 
ATOM   3266 N  NE2 . GLN B 1 229 ? -40.57133 39.54855 -34.02140 1.000 74.37000  ? 209 GLN B NE2 1 
ATOM   3267 N  N   . SER B 1 230 ? -45.14411 38.96816 -32.56244 1.000 59.98000  ? 210 SER B N   1 
ATOM   3268 C  CA  . SER B 1 230 ? -45.69771 40.31342 -32.44598 1.000 68.70000  ? 210 SER B CA  1 
ATOM   3269 C  C   . SER B 1 230 ? -45.39359 40.92362 -31.08655 1.000 77.68000  ? 210 SER B C   1 
ATOM   3270 O  O   . SER B 1 230 ? -45.21975 42.14373 -30.97301 1.000 81.78000  ? 210 SER B O   1 
ATOM   3271 C  CB  . SER B 1 230 ? -47.20343 40.29289 -32.68430 1.000 64.58000  ? 210 SER B CB  1 
ATOM   3272 N  N   . LEU B 1 231 ? -45.31052 40.08869 -30.04786 1.000 72.30000  ? 211 LEU B N   1 
ATOM   3273 C  CA  . LEU B 1 231 ? -44.87299 40.57066 -28.74948 1.000 74.76000  ? 211 LEU B CA  1 
ATOM   3274 C  C   . LEU B 1 231 ? -43.38378 40.89059 -28.75402 1.000 77.51000  ? 211 LEU B C   1 
ATOM   3275 O  O   . LEU B 1 231 ? -42.95951 41.90615 -28.18598 1.000 73.38000  ? 211 LEU B O   1 
ATOM   3276 C  CB  . LEU B 1 231 ? -45.19124 39.53146 -27.67801 1.000 72.41000  ? 211 LEU B CB  1 
ATOM   3277 C  CG  . LEU B 1 231 ? -46.65504 39.18917 -27.44741 1.000 69.91000  ? 211 LEU B CG  1 
ATOM   3278 C  CD1 . LEU B 1 231 ? -46.71165 37.79775 -26.85151 1.000 57.85000  ? 211 LEU B CD1 1 
ATOM   3279 C  CD2 . LEU B 1 231 ? -47.32988 40.22257 -26.54369 1.000 67.15000  ? 211 LEU B CD2 1 
ATOM   3280 N  N   . TYR B 1 232 ? -42.57055 40.01737 -29.35290 1.000 72.17000  ? 212 TYR B N   1 
ATOM   3281 C  CA  . TYR B 1 232 ? -41.13608 40.27427 -29.39682 1.000 77.29000  ? 212 TYR B CA  1 
ATOM   3282 C  C   . TYR B 1 232 ? -40.84631 41.57729 -30.12246 1.000 78.01000  ? 212 TYR B C   1 
ATOM   3283 O  O   . TYR B 1 232 ? -39.95933 42.33967 -29.72267 1.000 78.07000  ? 212 TYR B O   1 
ATOM   3284 C  CB  . TYR B 1 232 ? -40.40865 39.11301 -30.07118 1.000 79.43000  ? 212 TYR B CB  1 
ATOM   3285 C  CG  . TYR B 1 232 ? -39.77795 38.14558 -29.09446 1.000 82.42000  ? 212 TYR B CG  1 
ATOM   3286 C  CD1 . TYR B 1 232 ? -40.43780 37.77934 -27.92829 1.000 78.92000  ? 212 TYR B CD1 1 
ATOM   3287 C  CD2 . TYR B 1 232 ? -38.52017 37.59938 -29.33843 1.000 81.70000  ? 212 TYR B CD2 1 
ATOM   3288 C  CE1 . TYR B 1 232 ? -39.86533 36.88311 -27.03110 1.000 79.12000  ? 212 TYR B CE1 1 
ATOM   3289 C  CE2 . TYR B 1 232 ? -37.93756 36.71122 -28.44833 1.000 77.11000  ? 212 TYR B CE2 1 
ATOM   3290 C  CZ  . TYR B 1 232 ? -38.61338 36.35431 -27.29236 1.000 83.88000  ? 212 TYR B CZ  1 
ATOM   3291 O  OH  . TYR B 1 232 ? -38.04123 35.46980 -26.40031 1.000 84.38000  ? 212 TYR B OH  1 
ATOM   3292 N  N   . GLY B 1 233 ? -41.60032 41.85914 -31.18048 1.000 75.76000  ? 213 GLY B N   1 
ATOM   3293 C  CA  . GLY B 1 233 ? -41.45928 43.14112 -31.84423 1.000 80.45000  ? 213 GLY B CA  1 
ATOM   3294 C  C   . GLY B 1 233 ? -41.81790 44.29769 -30.93062 1.000 83.38000  ? 213 GLY B C   1 
ATOM   3295 O  O   . GLY B 1 233 ? -41.13947 45.33025 -30.92218 1.000 79.47000  ? 213 GLY B O   1 
ATOM   3296 N  N   . PHE B 1 234 ? -42.87679 44.12448 -30.12942 1.000 83.57000  ? 214 PHE B N   1 
ATOM   3297 C  CA  . PHE B 1 234 ? -43.30580 45.18540 -29.22168 1.000 76.46000  ? 214 PHE B CA  1 
ATOM   3298 C  C   . PHE B 1 234 ? -42.24917 45.46358 -28.16117 1.000 77.01000  ? 214 PHE B C   1 
ATOM   3299 O  O   . PHE B 1 234 ? -42.00574 46.62301 -27.80299 1.000 77.94000  ? 214 PHE B O   1 
ATOM   3300 C  CB  . PHE B 1 234 ? -44.64107 44.81812 -28.57402 1.000 68.66000  ? 214 PHE B CB  1 
ATOM   3301 C  CG  . PHE B 1 234 ? -44.98293 45.64831 -27.36441 1.000 73.71000  ? 214 PHE B CG  1 
ATOM   3302 C  CD1 . PHE B 1 234 ? -45.60592 46.87529 -27.50736 1.000 75.91000  ? 214 PHE B CD1 1 
ATOM   3303 C  CD2 . PHE B 1 234 ? -44.72492 45.18035 -26.08472 1.000 70.07000  ? 214 PHE B CD2 1 
ATOM   3304 C  CE1 . PHE B 1 234 ? -45.93091 47.63265 -26.40501 1.000 77.33000  ? 214 PHE B CE1 1 
ATOM   3305 C  CE2 . PHE B 1 234 ? -45.05017 45.92752 -24.97540 1.000 69.76000  ? 214 PHE B CE2 1 
ATOM   3306 C  CZ  . PHE B 1 234 ? -45.65182 47.15748 -25.13158 1.000 76.62000  ? 214 PHE B CZ  1 
ATOM   3307 N  N   . LEU B 1 235 ? -41.60438 44.42210 -27.65015 1.000 79.52000  ? 215 LEU B N   1 
ATOM   3308 C  CA  . LEU B 1 235 ? -40.61421 44.64487 -26.61020 1.000 78.02000  ? 215 LEU B CA  1 
ATOM   3309 C  C   . LEU B 1 235 ? -39.30981 45.19737 -27.16753 1.000 83.63000  ? 215 LEU B C   1 
ATOM   3310 O  O   . LEU B 1 235 ? -38.57380 45.85861 -26.42602 1.000 79.09000  ? 215 LEU B O   1 
ATOM   3311 C  CB  . LEU B 1 235 ? -40.37323 43.34068 -25.83660 1.000 31.63000  ? 215 LEU B CB  1 
ATOM   3312 N  N   . ASP B 1 236 ? -39.02079 44.93971 -28.45181 1.000 81.87000  ? 216 ASP B N   1 
ATOM   3313 C  CA  . ASP B 1 236 ? -37.86500 45.53073 -29.12471 1.000 82.32000  ? 216 ASP B CA  1 
ATOM   3314 C  C   . ASP B 1 236 ? -37.86263 47.05259 -28.98779 1.000 85.11000  ? 216 ASP B C   1 
ATOM   3315 O  O   . ASP B 1 236 ? -36.85136 47.66359 -28.61834 1.000 87.96000  ? 216 ASP B O   1 
ATOM   3316 C  CB  . ASP B 1 236 ? -37.87725 45.13296 -30.61043 1.000 82.05000  ? 216 ASP B CB  1 
ATOM   3317 C  CG  . ASP B 1 236 ? -37.41620 43.68304 -30.85739 1.000 87.75000  ? 216 ASP B CG  1 
ATOM   3318 O  OD1 . ASP B 1 236 ? -36.67276 43.13573 -30.00743 1.000 89.37000  ? 216 ASP B OD1 1 
ATOM   3319 O  OD2 . ASP B 1 236 ? -37.79654 43.09185 -31.90220 1.000 84.14000  ? 216 ASP B OD2 1 
ATOM   3320 N  N   . SER B 1 237 ? -39.02129 47.66612 -29.24644 1.000 80.54000  ? 217 SER B N   1 
ATOM   3321 C  CA  . SER B 1 237 ? -39.17307 49.11557 -29.35691 1.000 80.88000  ? 217 SER B CA  1 
ATOM   3322 C  C   . SER B 1 237 ? -38.54677 49.89789 -28.20806 1.000 84.83000  ? 217 SER B C   1 
ATOM   3323 O  O   . SER B 1 237 ? -38.19035 51.06967 -28.37968 1.000 86.72000  ? 217 SER B O   1 
ATOM   3324 C  CB  . SER B 1 237 ? -40.66062 49.45657 -29.44325 1.000 80.38000  ? 217 SER B CB  1 
ATOM   3325 O  OG  . SER B 1 237 ? -41.14868 49.89604 -28.18209 1.000 85.18000  ? 217 SER B OG  1 
ATOM   3326 N  N   . PHE B 1 238 ? -38.42485 49.29595 -27.03234 1.000 80.34000  ? 218 PHE B N   1 
ATOM   3327 C  CA  . PHE B 1 238 ? -37.87890 50.00529 -25.88438 1.000 89.34000  ? 218 PHE B CA  1 
ATOM   3328 C  C   . PHE B 1 238 ? -36.35954 49.91964 -25.80961 1.000 89.68000  ? 218 PHE B C   1 
ATOM   3329 O  O   . PHE B 1 238 ? -35.77706 50.30811 -24.78843 1.000 89.48000  ? 218 PHE B O   1 
ATOM   3330 C  CB  . PHE B 1 238 ? -38.50786 49.47688 -24.58768 1.000 87.77000  ? 218 PHE B CB  1 
ATOM   3331 C  CG  . PHE B 1 238 ? -40.00851 49.48314 -24.60355 1.000 82.57000  ? 218 PHE B CG  1 
ATOM   3332 C  CD1 . PHE B 1 238 ? -40.70717 50.67368 -24.49903 1.000 81.51000  ? 218 PHE B CD1 1 
ATOM   3333 C  CD2 . PHE B 1 238 ? -40.71981 48.30506 -24.76010 1.000 78.49000  ? 218 PHE B CD2 1 
ATOM   3334 C  CE1 . PHE B 1 238 ? -42.08214 50.68919 -24.53266 1.000 79.19000  ? 218 PHE B CE1 1 
ATOM   3335 C  CE2 . PHE B 1 238 ? -42.10279 48.31699 -24.79940 1.000 80.65000  ? 218 PHE B CE2 1 
ATOM   3336 C  CZ  . PHE B 1 238 ? -42.78247 49.51099 -24.68794 1.000 77.82000  ? 218 PHE B CZ  1 
ATOM   3337 N  N   . LEU B 1 239 ? -35.70800 49.43632 -26.86418 1.000 81.93000  ? 219 LEU B N   1 
ATOM   3338 C  CA  . LEU B 1 239 ? -34.27080 49.21462 -26.82274 1.000 87.75000  ? 219 LEU B CA  1 
ATOM   3339 C  C   . LEU B 1 239 ? -33.62708 49.54131 -28.17151 1.000 90.37000  ? 219 LEU B C   1 
ATOM   3340 O  O   . LEU B 1 239 ? -33.55626 50.70783 -28.57589 1.000 93.35000  ? 219 LEU B O   1 
ATOM   3341 C  CB  . LEU B 1 239 ? -33.97676 47.76062 -26.39563 0.435 31.63000  ? 219 LEU B CB  1 
ATOM   3342 C  CG  . LEU B 1 239 ? -34.21370 47.48416 -24.88589 0.864 31.63000  ? 219 LEU B CG  1 
HETATM 3343 FE FE  . FE2 C 2 .   ? -38.14866 10.14729 -18.37905 0.850 72.23589  ? 301 FE2 A FE  1 
HETATM 3344 MN MN  . MN  D 3 .   ? -41.74066 11.97855 -18.57662 0.850 61.60482  ? 302 MN  A MN  1 
HETATM 3345 C  C1  . GOL E 4 .   ? -53.12714 21.93280 -43.87478 0.732 34.08000  ? 301 GOL B C1  1 
HETATM 3346 O  O1  . GOL E 4 .   ? -51.84140 22.48285 -43.65219 0.732 34.08000  ? 301 GOL B O1  1 
HETATM 3347 C  C2  . GOL E 4 .   ? -54.03282 23.18274 -43.91923 0.732 34.08000  ? 301 GOL B C2  1 
HETATM 3348 O  O2  . GOL E 4 .   ? -54.37732 23.60587 -45.27864 0.732 34.08000  ? 301 GOL B O2  1 
HETATM 3349 C  C3  . GOL E 4 .   ? -55.26996 22.76137 -43.10790 0.732 34.08000  ? 301 GOL B C3  1 
HETATM 3350 O  O3  . GOL E 4 .   ? -56.12953 23.85423 -43.32092 0.732 34.08000  ? 301 GOL B O3  1 
HETATM 3351 FE FE  . FE2 F 2 .   ? -55.71967 40.97350 -17.50464 0.950 85.77705  ? 302 FE2 B FE  1 
HETATM 3352 MN MN  . MN  G 3 .   ? -56.02786 36.97008 -18.23781 0.950 63.04859  ? 303 MN  B MN  1 
HETATM 3353 O  O   . HOH H 5 .   ? -40.39538 29.33325 -7.74197  0.760 31.63000  ? 401 HOH A O   1 
HETATM 3354 O  O   . HOH H 5 .   ? -47.62554 28.49417 -14.21609 1.000 34.08000  ? 402 HOH A O   1 
HETATM 3355 O  O   . HOH H 5 .   ? -45.42091 6.09659  -26.28293 1.000 31.63000  ? 403 HOH A O   1 
HETATM 3356 O  O   . HOH H 5 .   ? -51.87185 8.95963  -3.48080  1.000 37.17000  ? 404 HOH A O   1 
HETATM 3357 O  O   . HOH H 5 .   ? -49.34903 9.63879  -21.05098 0.510 31.63000  ? 405 HOH A O   1 
HETATM 3358 O  O   . HOH H 5 .   ? -44.89466 7.97809  -27.14564 0.519 31.63000  ? 406 HOH A O   1 
HETATM 3359 O  O   . HOH H 5 .   ? -46.45024 -1.02790 -6.08172  1.000 37.17000  ? 407 HOH A O   1 
HETATM 3360 O  O   . HOH H 5 .   ? -59.73911 7.16713  -9.05964  1.000 31.63000  ? 408 HOH A O   1 
HETATM 3361 O  O   . HOH H 5 .   ? -24.99336 3.35994  -8.37189  0.645 30.00000  ? 409 HOH A O   1 
HETATM 3362 O  O   . HOH H 5 .   ? -59.56300 -3.44588 -13.94003 1.000 30.00000  ? 410 HOH A O   1 
HETATM 3363 O  O   . HOH H 5 .   ? -39.93228 10.98934 -19.48277 0.850 37.17000  ? 411 HOH A O   1 
HETATM 3364 O  O   . HOH H 5 .   ? -34.00517 3.01294  -8.47929  1.000 37.17000  ? 412 HOH A O   1 
HETATM 3365 O  O   . HOH H 5 .   ? -50.31175 -2.99610 -6.89326  1.000 37.17000  ? 413 HOH A O   1 
HETATM 3366 O  O   . HOH H 5 .   ? -57.87148 9.46314  -6.56136  1.000 34.08000  ? 414 HOH A O   1 
HETATM 3367 O  O   . HOH H 5 .   ? -57.74757 6.78142  -5.94651  1.000 37.17000  ? 415 HOH A O   1 
HETATM 3368 O  O   . HOH H 5 .   ? -41.76699 10.19769 -17.75023 0.850 37.17000  ? 416 HOH A O   1 
HETATM 3369 O  O   . HOH H 5 .   ? -54.32010 24.70702 -13.81745 0.594 31.63000  ? 417 HOH A O   1 
HETATM 3370 O  O   . HOH H 5 .   ? -56.09090 29.35349 -6.89008  1.000 37.17000  ? 418 HOH A O   1 
HETATM 3371 O  O   . HOH H 5 .   ? -62.95723 1.92858  -17.48156 1.000 31.63000  ? 419 HOH A O   1 
HETATM 3372 O  O   . HOH H 5 .   ? -44.59496 26.31939 -3.13918  1.000 37.17000  ? 420 HOH A O   1 
HETATM 3373 O  O   . HOH H 5 .   ? -60.34436 3.12869  -10.87179 0.715 30.00000  ? 421 HOH A O   1 
HETATM 3374 O  O   . HOH H 5 .   ? -32.03087 9.88586  -7.11899  1.000 37.17000  ? 422 HOH A O   1 
HETATM 3375 O  O   . HOH H 5 .   ? -53.87573 19.11326 -19.61357 1.000 37.17000  ? 423 HOH A O   1 
HETATM 3376 O  O   . HOH H 5 .   ? -40.06413 11.72750 -16.87002 0.850 37.17000  ? 424 HOH A O   1 
HETATM 3377 O  O   . HOH H 5 .   ? -26.79117 2.79812  -22.71670 1.000 34.08000  ? 425 HOH A O   1 
HETATM 3378 O  O   . HOH H 5 .   ? -41.67100 4.40896  -27.04354 1.000 31.63000  ? 426 HOH A O   1 
HETATM 3379 O  O   . HOH H 5 .   ? -19.51319 7.46353  -3.54109  0.582 31.63000  ? 427 HOH A O   1 
HETATM 3380 O  O   . HOH H 5 .   ? -64.07263 25.00691 -10.91776 1.000 30.00000  ? 428 HOH A O   1 
HETATM 3381 O  O   . HOH H 5 .   ? -21.87772 31.97297 -10.63799 1.000 37.17000  ? 429 HOH A O   1 
HETATM 3382 O  O   . HOH H 5 .   ? -60.67596 5.38180  -10.66918 1.000 30.00000  ? 430 HOH A O   1 
HETATM 3383 O  O   . HOH I 5 .   ? -50.90782 50.27900 1.16783   0.480 31.63000  ? 401 HOH B O   1 
HETATM 3384 O  O   . HOH I 5 .   ? -64.55969 35.58227 -13.24330 0.638 30.00000  ? 402 HOH B O   1 
HETATM 3385 O  O   . HOH I 5 .   ? -35.56229 39.54734 -9.70457  0.528 34.08000  ? 403 HOH B O   1 
HETATM 3386 O  O   . HOH I 5 .   ? -59.87592 40.69628 -8.22109  0.536 30.00000  ? 404 HOH B O   1 
HETATM 3387 O  O   . HOH I 5 .   ? -50.43085 48.83965 -25.91770 0.441 30.00000  ? 405 HOH B O   1 
HETATM 3388 O  O   . HOH I 5 .   ? -64.63641 49.61729 -13.06217 0.547 37.17000  ? 406 HOH B O   1 
HETATM 3389 O  O   . HOH I 5 .   ? -57.50502 37.79305 -19.33842 0.950 37.17000  ? 407 HOH B O   1 
HETATM 3390 O  O   . HOH I 5 .   ? -58.72626 47.35608 -30.41231 1.000 37.17000  ? 408 HOH B O   1 
HETATM 3391 O  O   . HOH I 5 .   ? -62.44228 26.76667 -34.89073 1.000 37.17000  ? 409 HOH B O   1 
HETATM 3392 O  O   . HOH I 5 .   ? -68.98988 29.45036 -16.12318 1.000 37.17000  ? 410 HOH B O   1 
HETATM 3393 O  O   . HOH I 5 .   ? -43.46995 36.13723 -26.78011 0.605 31.63000  ? 411 HOH B O   1 
HETATM 3394 O  O   . HOH I 5 .   ? -42.29334 31.95336 -4.21484  1.000 34.08000  ? 412 HOH B O   1 
HETATM 3395 O  O   . HOH I 5 .   ? -75.809   30.950   -30.673   1.000 34.08000  ? 413 HOH B O   1 
HETATM 3396 O  O   . HOH I 5 .   ? -36.03931 52.85329 -28.28302 1.000 30.00000  ? 414 HOH B O   1 
HETATM 3397 O  O   . HOH I 5 .   ? -69.70218 27.66220 -32.53905 1.000 30.00000  ? 415 HOH B O   1 
HETATM 3398 O  O   . HOH I 5 .   ? -73.87289 24.51514 -27.27964 0.607 30.00000  ? 416 HOH B O   1 
HETATM 3399 O  O   . HOH I 5 .   ? -64.27069 28.09394 -35.61569 0.761 31.63000  ? 417 HOH B O   1 
HETATM 3400 O  O   . HOH I 5 .   ? -73.58057 24.31609 -29.77847 1.000 30.00000  ? 418 HOH B O   1 
HETATM 3401 O  O   . HOH I 5 .   ? -54.89837 38.92170 -19.42249 0.950 37.17000  ? 419 HOH B O   1 
HETATM 3402 O  O   . HOH I 5 .   ? -36.76174 40.25415 -31.85930 1.000 37.17000  ? 420 HOH B O   1 
HETATM 3403 O  O   . HOH I 5 .   ? -45.62861 26.69821 -22.88654 1.000 31.63000  ? 421 HOH B O   1 
HETATM 3404 O  O   . HOH I 5 .   ? -57.78423 49.85245 -26.94380 1.000 37.17000  ? 422 HOH B O   1 
HETATM 3405 O  O   . HOH I 5 .   ? -55.26951 61.03819 -26.81814 1.000 34.08000  ? 423 HOH B O   1 
HETATM 3406 O  O   . HOH I 5 .   ? -51.79730 27.28836 -16.21035 1.000 37.17000  ? 424 HOH B O   1 
HETATM 3407 O  O   . HOH I 5 .   ? -59.96162 22.06581 -17.08110 1.000 30.00000  ? 425 HOH B O   1 
HETATM 3408 O  O   . HOH I 5 .   ? -49.36685 24.30359 -19.83961 0.769 31.63000  ? 426 HOH B O   1 
HETATM 3409 O  O   . HOH I 5 .   ? -62.74125 50.63277 -17.54810 1.000 37.17000  ? 427 HOH B O   1 
HETATM 3410 O  O   . HOH I 5 .   ? -38.90987 40.57469 -36.71754 1.000 30.00000  ? 428 HOH B O   1 
HETATM 3411 O  O   . HOH I 5 .   ? -42.25042 51.31328 -32.01009 1.000 31.63000  ? 429 HOH B O   1 
HETATM 3412 O  O   . HOH I 5 .   ? -60.02238 38.72473 -6.45989  0.633 30.00000  ? 430 HOH B O   1 
HETATM 3413 O  O   . HOH I 5 .   ? -66.10340 37.87436 -12.02436 0.690 30.00000  ? 431 HOH B O   1 
HETATM 3414 O  O   . HOH I 5 .   ? -32.33493 47.52344 -30.19362 1.000 30.00000  ? 432 HOH B O   1 
HETATM 3415 O  O   . HOH I 5 .   ? -70.71401 20.46689 -27.46457 1.000 30.00000  ? 433 HOH B O   1 
HETATM 3416 O  O   . HOH I 5 .   ? -55.57082 35.28111 -39.49019 1.000 34.08000  ? 434 HOH B O   1 
HETATM 3417 O  O   . HOH I 5 .   ? -63.46770 39.65380 -4.76892  0.613 30.00000  ? 435 HOH B O   1 
# 
loop_
_atom_site_anisotrop.id 
_atom_site_anisotrop.type_symbol 
_atom_site_anisotrop.pdbx_label_atom_id 
_atom_site_anisotrop.pdbx_label_alt_id 
_atom_site_anisotrop.pdbx_label_comp_id 
_atom_site_anisotrop.pdbx_label_asym_id 
_atom_site_anisotrop.pdbx_label_seq_id 
_atom_site_anisotrop.pdbx_PDB_ins_code 
_atom_site_anisotrop.U[1][1] 
_atom_site_anisotrop.U[2][2] 
_atom_site_anisotrop.U[3][3] 
_atom_site_anisotrop.U[1][2] 
_atom_site_anisotrop.U[1][3] 
_atom_site_anisotrop.U[2][3] 
_atom_site_anisotrop.pdbx_auth_seq_id 
_atom_site_anisotrop.pdbx_auth_comp_id 
_atom_site_anisotrop.pdbx_auth_asym_id 
_atom_site_anisotrop.pdbx_auth_atom_id 
3343 FE FE . FE2 C . ? 0.90878 0.89198 0.94388 0.37617 0.20395  0.15946  301 FE2 A FE 
3344 MN MN . MN  D . ? 0.81019 0.76517 0.76534 0.41215 0.24456  0.06178  302 MN  A MN 
3351 FE FE . FE2 F . ? 1.02406 1.08491 1.15018 0.35127 -0.10179 -0.11626 302 FE2 B FE 
3352 MN MN . MN  G . ? 0.79495 0.75003 0.85058 0.27036 -0.06961 0.08107  303 MN  B MN 
# 
