data_8V2S
# 
_entry.id   8V2S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8V2S         pdb_00008v2s 10.2210/pdb8v2s/pdb 
WWPDB D_1000279392 ?            ?                   
EMDB  EMD-42932    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8V2S 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'CHMP1B/IST1 dsDNA bound copolymer' 
_pdbx_database_related.db_id          EMD-42932 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 afrost@altoslabs.com          Adam   Frost          ? 'principal investigator/group leader' 0000-0003-2231-2577 
3 wes@biochem.utah.edu          Wesley Sundquist      I 'principal investigator/group leader' 0000-0001-9988-6021 
4 juan.martin_serrano@kcl.ac.uk Juan   Martin-Serrano ? 'principal investigator/group leader' 0000-0002-8183-3914 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Talledge, N.'   1 0000-0002-4603-0120 
'Laughlin, T.G.' 2 0000-0001-8943-1330 
'Alian, A.'      3 0000-0003-1901-3832 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'ESCRT-III Assembles Around Mis-segregated DNA to Engage NoCut' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Talledge, N.'       1  0000-0002-4603-0120 
primary 'Glover, J.'         2  ?                   
primary 'McCullough, J.'     3  0000-0001-6836-4394 
primary 'Alian, A.'          4  0000-0003-1901-3832 
primary 'Sadler, J.B.A.'     5  ?                   
primary 'Dempsey, N.'        6  ?                   
primary 'Laughlin, T.G.'     7  0000-0001-8943-1330 
primary 'Nguyen, H.C.'       8  0000-0002-6142-8807 
primary 'Wenzel, D.'         9  0000-0002-3605-6220 
primary 'Lalonde, M.S.'      10 ?                   
primary 'Ventimiglia, L.N.'  11 ?                   
primary 'LaJoie, D.'         12 ?                   
primary 'Iwasa, J.'          13 0000-0002-4949-7607 
primary 'Starling, T.'       14 ?                   
primary 'Padilla-Parra, S.'  15 ?                   
primary 'Ullman, K.S.'       16 0000-0003-3693-2830 
primary 'Frost, A.'          17 0000-0003-2231-2577 
primary 'Sundquist, W.I.'    18 0000-0001-9988-6021 
primary 'Martin-Serrano, J.' 19 0000-0002-8183-3914 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Charged multivesicular body protein 1b' 22108.355 1 ? M136V ? ? 
2 polymer man 'IST1 homolog'                           39796.402 1 ? ?     ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        'hIST1,Charged multivesicular body protein 8,CHMP8,Putative MAPK-activating protein PM28' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQ
TAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTVSSTTTLTTPQNQVDMLLQEMADEA
GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
;
;MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQ
TAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTVSSTTTLTTPQNQVDMLLQEMADEA
GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
;
A ? 
2 'polypeptide(L)' no no 
;MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLL
ARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKI
LVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDN
FVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
;
;MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLL
ARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKI
LVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDN
FVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
;
B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   ASN n 
1 4   MET n 
1 5   GLU n 
1 6   LYS n 
1 7   HIS n 
1 8   LEU n 
1 9   PHE n 
1 10  ASN n 
1 11  LEU n 
1 12  LYS n 
1 13  PHE n 
1 14  ALA n 
1 15  ALA n 
1 16  LYS n 
1 17  GLU n 
1 18  LEU n 
1 19  SER n 
1 20  ARG n 
1 21  SER n 
1 22  ALA n 
1 23  LYS n 
1 24  LYS n 
1 25  CYS n 
1 26  ASP n 
1 27  LYS n 
1 28  GLU n 
1 29  GLU n 
1 30  LYS n 
1 31  ALA n 
1 32  GLU n 
1 33  LYS n 
1 34  ALA n 
1 35  LYS n 
1 36  ILE n 
1 37  LYS n 
1 38  LYS n 
1 39  ALA n 
1 40  ILE n 
1 41  GLN n 
1 42  LYS n 
1 43  GLY n 
1 44  ASN n 
1 45  MET n 
1 46  GLU n 
1 47  VAL n 
1 48  ALA n 
1 49  ARG n 
1 50  ILE n 
1 51  HIS n 
1 52  ALA n 
1 53  GLU n 
1 54  ASN n 
1 55  ALA n 
1 56  ILE n 
1 57  ARG n 
1 58  GLN n 
1 59  LYS n 
1 60  ASN n 
1 61  GLN n 
1 62  ALA n 
1 63  VAL n 
1 64  ASN n 
1 65  PHE n 
1 66  LEU n 
1 67  ARG n 
1 68  MET n 
1 69  SER n 
1 70  ALA n 
1 71  ARG n 
1 72  VAL n 
1 73  ASP n 
1 74  ALA n 
1 75  VAL n 
1 76  ALA n 
1 77  ALA n 
1 78  ARG n 
1 79  VAL n 
1 80  GLN n 
1 81  THR n 
1 82  ALA n 
1 83  VAL n 
1 84  THR n 
1 85  MET n 
1 86  GLY n 
1 87  LYS n 
1 88  VAL n 
1 89  THR n 
1 90  LYS n 
1 91  SER n 
1 92  MET n 
1 93  ALA n 
1 94  GLY n 
1 95  VAL n 
1 96  VAL n 
1 97  LYS n 
1 98  SER n 
1 99  MET n 
1 100 ASP n 
1 101 ALA n 
1 102 THR n 
1 103 LEU n 
1 104 LYS n 
1 105 THR n 
1 106 MET n 
1 107 ASN n 
1 108 LEU n 
1 109 GLU n 
1 110 LYS n 
1 111 ILE n 
1 112 SER n 
1 113 ALA n 
1 114 LEU n 
1 115 MET n 
1 116 ASP n 
1 117 LYS n 
1 118 PHE n 
1 119 GLU n 
1 120 HIS n 
1 121 GLN n 
1 122 PHE n 
1 123 GLU n 
1 124 THR n 
1 125 LEU n 
1 126 ASP n 
1 127 VAL n 
1 128 GLN n 
1 129 THR n 
1 130 GLN n 
1 131 GLN n 
1 132 MET n 
1 133 GLU n 
1 134 ASP n 
1 135 THR n 
1 136 VAL n 
1 137 SER n 
1 138 SER n 
1 139 THR n 
1 140 THR n 
1 141 THR n 
1 142 LEU n 
1 143 THR n 
1 144 THR n 
1 145 PRO n 
1 146 GLN n 
1 147 ASN n 
1 148 GLN n 
1 149 VAL n 
1 150 ASP n 
1 151 MET n 
1 152 LEU n 
1 153 LEU n 
1 154 GLN n 
1 155 GLU n 
1 156 MET n 
1 157 ALA n 
1 158 ASP n 
1 159 GLU n 
1 160 ALA n 
1 161 GLY n 
1 162 LEU n 
1 163 ASP n 
1 164 LEU n 
1 165 ASN n 
1 166 MET n 
1 167 GLU n 
1 168 LEU n 
1 169 PRO n 
1 170 GLN n 
1 171 GLY n 
1 172 GLN n 
1 173 THR n 
1 174 GLY n 
1 175 SER n 
1 176 VAL n 
1 177 GLY n 
1 178 THR n 
1 179 SER n 
1 180 VAL n 
1 181 ALA n 
1 182 SER n 
1 183 ALA n 
1 184 GLU n 
1 185 GLN n 
1 186 ASP n 
1 187 GLU n 
1 188 LEU n 
1 189 SER n 
1 190 GLN n 
1 191 ARG n 
1 192 LEU n 
1 193 ALA n 
1 194 ARG n 
1 195 LEU n 
1 196 ARG n 
1 197 ASP n 
1 198 GLN n 
1 199 VAL n 
2 1   MET n 
2 2   LEU n 
2 3   GLY n 
2 4   SER n 
2 5   GLY n 
2 6   PHE n 
2 7   LYS n 
2 8   ALA n 
2 9   GLU n 
2 10  ARG n 
2 11  LEU n 
2 12  ARG n 
2 13  VAL n 
2 14  ASN n 
2 15  LEU n 
2 16  ARG n 
2 17  LEU n 
2 18  VAL n 
2 19  ILE n 
2 20  ASN n 
2 21  ARG n 
2 22  LEU n 
2 23  LYS n 
2 24  LEU n 
2 25  LEU n 
2 26  GLU n 
2 27  LYS n 
2 28  LYS n 
2 29  LYS n 
2 30  THR n 
2 31  GLU n 
2 32  LEU n 
2 33  ALA n 
2 34  GLN n 
2 35  LYS n 
2 36  ALA n 
2 37  ARG n 
2 38  LYS n 
2 39  GLU n 
2 40  ILE n 
2 41  ALA n 
2 42  ASP n 
2 43  TYR n 
2 44  LEU n 
2 45  ALA n 
2 46  ALA n 
2 47  GLY n 
2 48  LYS n 
2 49  ASP n 
2 50  GLU n 
2 51  ARG n 
2 52  ALA n 
2 53  ARG n 
2 54  ILE n 
2 55  ARG n 
2 56  VAL n 
2 57  GLU n 
2 58  HIS n 
2 59  ILE n 
2 60  ILE n 
2 61  ARG n 
2 62  GLU n 
2 63  ASP n 
2 64  TYR n 
2 65  LEU n 
2 66  VAL n 
2 67  GLU n 
2 68  ALA n 
2 69  MET n 
2 70  GLU n 
2 71  ILE n 
2 72  LEU n 
2 73  GLU n 
2 74  LEU n 
2 75  TYR n 
2 76  CYS n 
2 77  ASP n 
2 78  LEU n 
2 79  LEU n 
2 80  LEU n 
2 81  ALA n 
2 82  ARG n 
2 83  PHE n 
2 84  GLY n 
2 85  LEU n 
2 86  ILE n 
2 87  GLN n 
2 88  SER n 
2 89  MET n 
2 90  LYS n 
2 91  GLU n 
2 92  LEU n 
2 93  ASP n 
2 94  SER n 
2 95  GLY n 
2 96  LEU n 
2 97  ALA n 
2 98  GLU n 
2 99  SER n 
2 100 VAL n 
2 101 SER n 
2 102 THR n 
2 103 LEU n 
2 104 ILE n 
2 105 TRP n 
2 106 ALA n 
2 107 ALA n 
2 108 PRO n 
2 109 ARG n 
2 110 LEU n 
2 111 GLN n 
2 112 SER n 
2 113 GLU n 
2 114 VAL n 
2 115 ALA n 
2 116 GLU n 
2 117 LEU n 
2 118 LYS n 
2 119 ILE n 
2 120 VAL n 
2 121 ALA n 
2 122 ASP n 
2 123 GLN n 
2 124 LEU n 
2 125 CYS n 
2 126 ALA n 
2 127 LYS n 
2 128 TYR n 
2 129 SER n 
2 130 LYS n 
2 131 GLU n 
2 132 TYR n 
2 133 GLY n 
2 134 LYS n 
2 135 LEU n 
2 136 CYS n 
2 137 ARG n 
2 138 THR n 
2 139 ASN n 
2 140 GLN n 
2 141 ILE n 
2 142 GLY n 
2 143 THR n 
2 144 VAL n 
2 145 ASN n 
2 146 ASP n 
2 147 ARG n 
2 148 LEU n 
2 149 MET n 
2 150 HIS n 
2 151 LYS n 
2 152 LEU n 
2 153 SER n 
2 154 VAL n 
2 155 GLU n 
2 156 ALA n 
2 157 PRO n 
2 158 PRO n 
2 159 LYS n 
2 160 ILE n 
2 161 LEU n 
2 162 VAL n 
2 163 GLU n 
2 164 ARG n 
2 165 TYR n 
2 166 LEU n 
2 167 ILE n 
2 168 GLU n 
2 169 ILE n 
2 170 ALA n 
2 171 LYS n 
2 172 ASN n 
2 173 TYR n 
2 174 ASN n 
2 175 VAL n 
2 176 PRO n 
2 177 TYR n 
2 178 GLU n 
2 179 PRO n 
2 180 ASP n 
2 181 SER n 
2 182 VAL n 
2 183 VAL n 
2 184 MET n 
2 185 ALA n 
2 186 GLU n 
2 187 ALA n 
2 188 PRO n 
2 189 PRO n 
2 190 GLY n 
2 191 VAL n 
2 192 GLU n 
2 193 THR n 
2 194 ASP n 
2 195 LEU n 
2 196 ILE n 
2 197 ASP n 
2 198 VAL n 
2 199 GLY n 
2 200 PHE n 
2 201 THR n 
2 202 ASP n 
2 203 ASP n 
2 204 VAL n 
2 205 LYS n 
2 206 LYS n 
2 207 GLY n 
2 208 GLY n 
2 209 PRO n 
2 210 GLY n 
2 211 ARG n 
2 212 GLY n 
2 213 GLY n 
2 214 SER n 
2 215 GLY n 
2 216 GLY n 
2 217 PHE n 
2 218 THR n 
2 219 ALA n 
2 220 PRO n 
2 221 VAL n 
2 222 GLY n 
2 223 GLY n 
2 224 PRO n 
2 225 ASP n 
2 226 GLY n 
2 227 THR n 
2 228 VAL n 
2 229 PRO n 
2 230 MET n 
2 231 PRO n 
2 232 MET n 
2 233 PRO n 
2 234 MET n 
2 235 PRO n 
2 236 MET n 
2 237 PRO n 
2 238 SER n 
2 239 ALA n 
2 240 ASN n 
2 241 THR n 
2 242 PRO n 
2 243 PHE n 
2 244 SER n 
2 245 TYR n 
2 246 PRO n 
2 247 LEU n 
2 248 PRO n 
2 249 LYS n 
2 250 GLY n 
2 251 PRO n 
2 252 SER n 
2 253 ASP n 
2 254 PHE n 
2 255 ASN n 
2 256 GLY n 
2 257 LEU n 
2 258 PRO n 
2 259 MET n 
2 260 GLY n 
2 261 THR n 
2 262 TYR n 
2 263 GLN n 
2 264 ALA n 
2 265 PHE n 
2 266 PRO n 
2 267 ASN n 
2 268 ILE n 
2 269 HIS n 
2 270 PRO n 
2 271 PRO n 
2 272 GLN n 
2 273 ILE n 
2 274 PRO n 
2 275 ALA n 
2 276 THR n 
2 277 PRO n 
2 278 PRO n 
2 279 SER n 
2 280 TYR n 
2 281 GLU n 
2 282 SER n 
2 283 VAL n 
2 284 ASP n 
2 285 ASP n 
2 286 ILE n 
2 287 ASN n 
2 288 ALA n 
2 289 ASP n 
2 290 LYS n 
2 291 ASN n 
2 292 ILE n 
2 293 SER n 
2 294 SER n 
2 295 ALA n 
2 296 GLN n 
2 297 ILE n 
2 298 VAL n 
2 299 GLY n 
2 300 PRO n 
2 301 GLY n 
2 302 PRO n 
2 303 LYS n 
2 304 PRO n 
2 305 GLU n 
2 306 ALA n 
2 307 SER n 
2 308 ALA n 
2 309 LYS n 
2 310 LEU n 
2 311 PRO n 
2 312 SER n 
2 313 ARG n 
2 314 PRO n 
2 315 ALA n 
2 316 ASP n 
2 317 ASN n 
2 318 TYR n 
2 319 ASP n 
2 320 ASN n 
2 321 PHE n 
2 322 VAL n 
2 323 LEU n 
2 324 PRO n 
2 325 GLU n 
2 326 LEU n 
2 327 PRO n 
2 328 SER n 
2 329 VAL n 
2 330 PRO n 
2 331 ASP n 
2 332 THR n 
2 333 LEU n 
2 334 PRO n 
2 335 THR n 
2 336 ALA n 
2 337 SER n 
2 338 ALA n 
2 339 GLY n 
2 340 ALA n 
2 341 SER n 
2 342 THR n 
2 343 SER n 
2 344 ALA n 
2 345 SER n 
2 346 GLU n 
2 347 ASP n 
2 348 ILE n 
2 349 ASP n 
2 350 PHE n 
2 351 ASP n 
2 352 ASP n 
2 353 LEU n 
2 354 SER n 
2 355 ARG n 
2 356 ARG n 
2 357 PHE n 
2 358 GLU n 
2 359 GLU n 
2 360 LEU n 
2 361 LYS n 
2 362 LYS n 
2 363 LYS n 
2 364 THR n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 199 human ? CHMP1B           ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? Plasmid ? 6xHIS-SUMO_CHMP1B ? 'pET28a(+)' ? ? 
2 1 sample 'Biological sequence' 1 364 human ? 'IST1, KIAA0174' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? Plasmid ? 6xHIS-SUMO_IST1   ? 'pET28c(+)' ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   SER 2   2   2   SER SER A . n 
A 1 3   ASN 3   3   3   ASN ASN A . n 
A 1 4   MET 4   4   4   MET MET A . n 
A 1 5   GLU 5   5   5   GLU GLU A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   HIS 7   7   7   HIS HIS A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   PHE 9   9   9   PHE PHE A . n 
A 1 10  ASN 10  10  10  ASN ASN A . n 
A 1 11  LEU 11  11  11  LEU LEU A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  PHE 13  13  13  PHE PHE A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  ALA 15  15  15  ALA ALA A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  GLU 17  17  17  GLU GLU A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  SER 19  19  19  SER SER A . n 
A 1 20  ARG 20  20  20  ARG ARG A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  LYS 23  23  23  LYS LYS A . n 
A 1 24  LYS 24  24  24  LYS LYS A . n 
A 1 25  CYS 25  25  25  CYS CYS A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  LYS 27  27  27  LYS LYS A . n 
A 1 28  GLU 28  28  28  GLU GLU A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  LYS 30  30  30  LYS LYS A . n 
A 1 31  ALA 31  31  31  ALA ALA A . n 
A 1 32  GLU 32  32  32  GLU GLU A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  ALA 34  34  34  ALA ALA A . n 
A 1 35  LYS 35  35  35  LYS LYS A . n 
A 1 36  ILE 36  36  36  ILE ILE A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  LYS 38  38  38  LYS LYS A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  GLN 41  41  41  GLN GLN A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  GLY 43  43  43  GLY GLY A . n 
A 1 44  ASN 44  44  44  ASN ASN A . n 
A 1 45  MET 45  45  45  MET MET A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  VAL 47  47  47  VAL VAL A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  GLU 53  53  53  GLU GLU A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  ILE 56  56  56  ILE ILE A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  LYS 59  59  59  LYS LYS A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  GLN 61  61  61  GLN GLN A . n 
A 1 62  ALA 62  62  62  ALA ALA A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  PHE 65  65  65  PHE PHE A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  MET 68  68  68  MET MET A . n 
A 1 69  SER 69  69  69  SER SER A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  ARG 71  71  71  ARG ARG A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  ASP 73  73  73  ASP ASP A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  VAL 75  75  75  VAL VAL A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  GLN 80  80  80  GLN GLN A . n 
A 1 81  THR 81  81  81  THR THR A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  THR 84  84  84  THR THR A . n 
A 1 85  MET 85  85  85  MET MET A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  LYS 87  87  87  LYS LYS A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  MET 92  92  92  MET MET A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  GLY 94  94  94  GLY GLY A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  SER 98  98  98  SER SER A . n 
A 1 99  MET 99  99  99  MET MET A . n 
A 1 100 ASP 100 100 100 ASP ASP A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 LYS 104 104 104 LYS LYS A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 MET 106 106 106 MET MET A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 LYS 110 110 110 LYS LYS A . n 
A 1 111 ILE 111 111 111 ILE ILE A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 MET 115 115 115 MET MET A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 LYS 117 117 117 LYS LYS A . n 
A 1 118 PHE 118 118 118 PHE PHE A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 HIS 120 120 120 HIS HIS A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 LEU 125 125 125 LEU LEU A . n 
A 1 126 ASP 126 126 126 ASP ASP A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 GLN 128 128 128 GLN GLN A . n 
A 1 129 THR 129 129 129 THR THR A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 GLN 131 131 131 GLN GLN A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 ASP 134 134 134 ASP ASP A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 VAL 136 136 136 VAL VAL A . n 
A 1 137 SER 137 137 137 SER SER A . n 
A 1 138 SER 138 138 138 SER SER A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 THR 140 140 140 THR THR A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 PRO 145 145 145 PRO PRO A . n 
A 1 146 GLN 146 146 146 GLN GLN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 VAL 149 149 149 VAL VAL A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 MET 151 151 151 MET MET A . n 
A 1 152 LEU 152 152 152 LEU LEU A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 GLN 154 154 154 GLN GLN A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 MET 156 156 156 MET MET A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 ASP 158 158 158 ASP ASP A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 LEU 162 162 162 LEU LEU A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 LEU 164 164 164 LEU LEU A . n 
A 1 165 ASN 165 165 165 ASN ASN A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 GLU 167 167 167 GLU GLU A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 PRO 169 169 169 PRO PRO A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 GLY 171 171 ?   ?   ?   A . n 
A 1 172 GLN 172 172 ?   ?   ?   A . n 
A 1 173 THR 173 173 ?   ?   ?   A . n 
A 1 174 GLY 174 174 ?   ?   ?   A . n 
A 1 175 SER 175 175 ?   ?   ?   A . n 
A 1 176 VAL 176 176 ?   ?   ?   A . n 
A 1 177 GLY 177 177 ?   ?   ?   A . n 
A 1 178 THR 178 178 ?   ?   ?   A . n 
A 1 179 SER 179 179 ?   ?   ?   A . n 
A 1 180 VAL 180 180 ?   ?   ?   A . n 
A 1 181 ALA 181 181 ?   ?   ?   A . n 
A 1 182 SER 182 182 ?   ?   ?   A . n 
A 1 183 ALA 183 183 ?   ?   ?   A . n 
A 1 184 GLU 184 184 ?   ?   ?   A . n 
A 1 185 GLN 185 185 ?   ?   ?   A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 GLU 187 187 187 GLU GLU A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 SER 189 189 189 SER SER A . n 
A 1 190 GLN 190 190 190 GLN GLN A . n 
A 1 191 ARG 191 191 191 ARG ARG A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 ARG 196 196 196 ARG ARG A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 GLN 198 198 198 GLN GLN A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   LEU 2   2   ?   ?   ?   B . n 
B 2 3   GLY 3   3   ?   ?   ?   B . n 
B 2 4   SER 4   4   4   SER SER B . n 
B 2 5   GLY 5   5   5   GLY GLY B . n 
B 2 6   PHE 6   6   6   PHE PHE B . n 
B 2 7   LYS 7   7   7   LYS LYS B . n 
B 2 8   ALA 8   8   8   ALA ALA B . n 
B 2 9   GLU 9   9   9   GLU GLU B . n 
B 2 10  ARG 10  10  10  ARG ARG B . n 
B 2 11  LEU 11  11  11  LEU LEU B . n 
B 2 12  ARG 12  12  12  ARG ARG B . n 
B 2 13  VAL 13  13  13  VAL VAL B . n 
B 2 14  ASN 14  14  14  ASN ASN B . n 
B 2 15  LEU 15  15  15  LEU LEU B . n 
B 2 16  ARG 16  16  16  ARG ARG B . n 
B 2 17  LEU 17  17  17  LEU LEU B . n 
B 2 18  VAL 18  18  18  VAL VAL B . n 
B 2 19  ILE 19  19  19  ILE ILE B . n 
B 2 20  ASN 20  20  20  ASN ASN B . n 
B 2 21  ARG 21  21  21  ARG ARG B . n 
B 2 22  LEU 22  22  22  LEU LEU B . n 
B 2 23  LYS 23  23  23  LYS LYS B . n 
B 2 24  LEU 24  24  24  LEU LEU B . n 
B 2 25  LEU 25  25  25  LEU LEU B . n 
B 2 26  GLU 26  26  26  GLU GLU B . n 
B 2 27  LYS 27  27  27  LYS LYS B . n 
B 2 28  LYS 28  28  28  LYS LYS B . n 
B 2 29  LYS 29  29  29  LYS LYS B . n 
B 2 30  THR 30  30  30  THR THR B . n 
B 2 31  GLU 31  31  31  GLU GLU B . n 
B 2 32  LEU 32  32  32  LEU LEU B . n 
B 2 33  ALA 33  33  33  ALA ALA B . n 
B 2 34  GLN 34  34  34  GLN GLN B . n 
B 2 35  LYS 35  35  35  LYS LYS B . n 
B 2 36  ALA 36  36  36  ALA ALA B . n 
B 2 37  ARG 37  37  37  ARG ARG B . n 
B 2 38  LYS 38  38  38  LYS LYS B . n 
B 2 39  GLU 39  39  39  GLU GLU B . n 
B 2 40  ILE 40  40  40  ILE ILE B . n 
B 2 41  ALA 41  41  41  ALA ALA B . n 
B 2 42  ASP 42  42  42  ASP ASP B . n 
B 2 43  TYR 43  43  43  TYR TYR B . n 
B 2 44  LEU 44  44  44  LEU LEU B . n 
B 2 45  ALA 45  45  45  ALA ALA B . n 
B 2 46  ALA 46  46  46  ALA ALA B . n 
B 2 47  GLY 47  47  47  GLY GLY B . n 
B 2 48  LYS 48  48  48  LYS LYS B . n 
B 2 49  ASP 49  49  49  ASP ASP B . n 
B 2 50  GLU 50  50  50  GLU GLU B . n 
B 2 51  ARG 51  51  51  ARG ARG B . n 
B 2 52  ALA 52  52  52  ALA ALA B . n 
B 2 53  ARG 53  53  53  ARG ARG B . n 
B 2 54  ILE 54  54  54  ILE ILE B . n 
B 2 55  ARG 55  55  55  ARG ARG B . n 
B 2 56  VAL 56  56  56  VAL VAL B . n 
B 2 57  GLU 57  57  57  GLU GLU B . n 
B 2 58  HIS 58  58  58  HIS HIS B . n 
B 2 59  ILE 59  59  59  ILE ILE B . n 
B 2 60  ILE 60  60  60  ILE ILE B . n 
B 2 61  ARG 61  61  61  ARG ARG B . n 
B 2 62  GLU 62  62  62  GLU GLU B . n 
B 2 63  ASP 63  63  63  ASP ASP B . n 
B 2 64  TYR 64  64  64  TYR TYR B . n 
B 2 65  LEU 65  65  65  LEU LEU B . n 
B 2 66  VAL 66  66  66  VAL VAL B . n 
B 2 67  GLU 67  67  67  GLU GLU B . n 
B 2 68  ALA 68  68  68  ALA ALA B . n 
B 2 69  MET 69  69  69  MET MET B . n 
B 2 70  GLU 70  70  70  GLU GLU B . n 
B 2 71  ILE 71  71  71  ILE ILE B . n 
B 2 72  LEU 72  72  72  LEU LEU B . n 
B 2 73  GLU 73  73  73  GLU GLU B . n 
B 2 74  LEU 74  74  74  LEU LEU B . n 
B 2 75  TYR 75  75  75  TYR TYR B . n 
B 2 76  CYS 76  76  76  CYS CYS B . n 
B 2 77  ASP 77  77  77  ASP ASP B . n 
B 2 78  LEU 78  78  78  LEU LEU B . n 
B 2 79  LEU 79  79  79  LEU LEU B . n 
B 2 80  LEU 80  80  80  LEU LEU B . n 
B 2 81  ALA 81  81  81  ALA ALA B . n 
B 2 82  ARG 82  82  82  ARG ARG B . n 
B 2 83  PHE 83  83  83  PHE PHE B . n 
B 2 84  GLY 84  84  84  GLY GLY B . n 
B 2 85  LEU 85  85  85  LEU LEU B . n 
B 2 86  ILE 86  86  86  ILE ILE B . n 
B 2 87  GLN 87  87  87  GLN GLN B . n 
B 2 88  SER 88  88  88  SER SER B . n 
B 2 89  MET 89  89  89  MET MET B . n 
B 2 90  LYS 90  90  90  LYS LYS B . n 
B 2 91  GLU 91  91  91  GLU GLU B . n 
B 2 92  LEU 92  92  92  LEU LEU B . n 
B 2 93  ASP 93  93  93  ASP ASP B . n 
B 2 94  SER 94  94  94  SER SER B . n 
B 2 95  GLY 95  95  95  GLY GLY B . n 
B 2 96  LEU 96  96  96  LEU LEU B . n 
B 2 97  ALA 97  97  97  ALA ALA B . n 
B 2 98  GLU 98  98  98  GLU GLU B . n 
B 2 99  SER 99  99  99  SER SER B . n 
B 2 100 VAL 100 100 100 VAL VAL B . n 
B 2 101 SER 101 101 101 SER SER B . n 
B 2 102 THR 102 102 102 THR THR B . n 
B 2 103 LEU 103 103 103 LEU LEU B . n 
B 2 104 ILE 104 104 104 ILE ILE B . n 
B 2 105 TRP 105 105 105 TRP TRP B . n 
B 2 106 ALA 106 106 106 ALA ALA B . n 
B 2 107 ALA 107 107 107 ALA ALA B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 ARG 109 109 109 ARG ARG B . n 
B 2 110 LEU 110 110 110 LEU LEU B . n 
B 2 111 GLN 111 111 111 GLN GLN B . n 
B 2 112 SER 112 112 112 SER SER B . n 
B 2 113 GLU 113 113 113 GLU GLU B . n 
B 2 114 VAL 114 114 114 VAL VAL B . n 
B 2 115 ALA 115 115 115 ALA ALA B . n 
B 2 116 GLU 116 116 116 GLU GLU B . n 
B 2 117 LEU 117 117 117 LEU LEU B . n 
B 2 118 LYS 118 118 118 LYS LYS B . n 
B 2 119 ILE 119 119 119 ILE ILE B . n 
B 2 120 VAL 120 120 120 VAL VAL B . n 
B 2 121 ALA 121 121 121 ALA ALA B . n 
B 2 122 ASP 122 122 122 ASP ASP B . n 
B 2 123 GLN 123 123 123 GLN GLN B . n 
B 2 124 LEU 124 124 124 LEU LEU B . n 
B 2 125 CYS 125 125 125 CYS CYS B . n 
B 2 126 ALA 126 126 126 ALA ALA B . n 
B 2 127 LYS 127 127 127 LYS LYS B . n 
B 2 128 TYR 128 128 128 TYR TYR B . n 
B 2 129 SER 129 129 129 SER SER B . n 
B 2 130 LYS 130 130 130 LYS LYS B . n 
B 2 131 GLU 131 131 131 GLU GLU B . n 
B 2 132 TYR 132 132 132 TYR TYR B . n 
B 2 133 GLY 133 133 133 GLY GLY B . n 
B 2 134 LYS 134 134 134 LYS LYS B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 CYS 136 136 136 CYS CYS B . n 
B 2 137 ARG 137 137 137 ARG ARG B . n 
B 2 138 THR 138 138 138 THR THR B . n 
B 2 139 ASN 139 139 139 ASN ASN B . n 
B 2 140 GLN 140 140 140 GLN GLN B . n 
B 2 141 ILE 141 141 141 ILE ILE B . n 
B 2 142 GLY 142 142 142 GLY GLY B . n 
B 2 143 THR 143 143 143 THR THR B . n 
B 2 144 VAL 144 144 144 VAL VAL B . n 
B 2 145 ASN 145 145 145 ASN ASN B . n 
B 2 146 ASP 146 146 146 ASP ASP B . n 
B 2 147 ARG 147 147 147 ARG ARG B . n 
B 2 148 LEU 148 148 148 LEU LEU B . n 
B 2 149 MET 149 149 149 MET MET B . n 
B 2 150 HIS 150 150 150 HIS HIS B . n 
B 2 151 LYS 151 151 151 LYS LYS B . n 
B 2 152 LEU 152 152 152 LEU LEU B . n 
B 2 153 SER 153 153 153 SER SER B . n 
B 2 154 VAL 154 154 154 VAL VAL B . n 
B 2 155 GLU 155 155 155 GLU GLU B . n 
B 2 156 ALA 156 156 156 ALA ALA B . n 
B 2 157 PRO 157 157 157 PRO PRO B . n 
B 2 158 PRO 158 158 158 PRO PRO B . n 
B 2 159 LYS 159 159 159 LYS LYS B . n 
B 2 160 ILE 160 160 160 ILE ILE B . n 
B 2 161 LEU 161 161 161 LEU LEU B . n 
B 2 162 VAL 162 162 162 VAL VAL B . n 
B 2 163 GLU 163 163 163 GLU GLU B . n 
B 2 164 ARG 164 164 164 ARG ARG B . n 
B 2 165 TYR 165 165 165 TYR TYR B . n 
B 2 166 LEU 166 166 166 LEU LEU B . n 
B 2 167 ILE 167 167 167 ILE ILE B . n 
B 2 168 GLU 168 168 168 GLU GLU B . n 
B 2 169 ILE 169 169 169 ILE ILE B . n 
B 2 170 ALA 170 170 170 ALA ALA B . n 
B 2 171 LYS 171 171 171 LYS LYS B . n 
B 2 172 ASN 172 172 172 ASN ASN B . n 
B 2 173 TYR 173 173 173 TYR TYR B . n 
B 2 174 ASN 174 174 174 ASN ASN B . n 
B 2 175 VAL 175 175 175 VAL VAL B . n 
B 2 176 PRO 176 176 176 PRO PRO B . n 
B 2 177 TYR 177 177 177 TYR TYR B . n 
B 2 178 GLU 178 178 178 GLU GLU B . n 
B 2 179 PRO 179 179 179 PRO PRO B . n 
B 2 180 ASP 180 180 180 ASP ASP B . n 
B 2 181 SER 181 181 181 SER SER B . n 
B 2 182 VAL 182 182 182 VAL VAL B . n 
B 2 183 VAL 183 183 183 VAL VAL B . n 
B 2 184 MET 184 184 184 MET MET B . n 
B 2 185 ALA 185 185 185 ALA ALA B . n 
B 2 186 GLU 186 186 186 GLU GLU B . n 
B 2 187 ALA 187 187 187 ALA ALA B . n 
B 2 188 PRO 188 188 ?   ?   ?   B . n 
B 2 189 PRO 189 189 ?   ?   ?   B . n 
B 2 190 GLY 190 190 ?   ?   ?   B . n 
B 2 191 VAL 191 191 ?   ?   ?   B . n 
B 2 192 GLU 192 192 ?   ?   ?   B . n 
B 2 193 THR 193 193 ?   ?   ?   B . n 
B 2 194 ASP 194 194 ?   ?   ?   B . n 
B 2 195 LEU 195 195 ?   ?   ?   B . n 
B 2 196 ILE 196 196 ?   ?   ?   B . n 
B 2 197 ASP 197 197 ?   ?   ?   B . n 
B 2 198 VAL 198 198 ?   ?   ?   B . n 
B 2 199 GLY 199 199 ?   ?   ?   B . n 
B 2 200 PHE 200 200 ?   ?   ?   B . n 
B 2 201 THR 201 201 ?   ?   ?   B . n 
B 2 202 ASP 202 202 ?   ?   ?   B . n 
B 2 203 ASP 203 203 ?   ?   ?   B . n 
B 2 204 VAL 204 204 ?   ?   ?   B . n 
B 2 205 LYS 205 205 ?   ?   ?   B . n 
B 2 206 LYS 206 206 ?   ?   ?   B . n 
B 2 207 GLY 207 207 ?   ?   ?   B . n 
B 2 208 GLY 208 208 ?   ?   ?   B . n 
B 2 209 PRO 209 209 ?   ?   ?   B . n 
B 2 210 GLY 210 210 ?   ?   ?   B . n 
B 2 211 ARG 211 211 ?   ?   ?   B . n 
B 2 212 GLY 212 212 ?   ?   ?   B . n 
B 2 213 GLY 213 213 ?   ?   ?   B . n 
B 2 214 SER 214 214 ?   ?   ?   B . n 
B 2 215 GLY 215 215 ?   ?   ?   B . n 
B 2 216 GLY 216 216 ?   ?   ?   B . n 
B 2 217 PHE 217 217 ?   ?   ?   B . n 
B 2 218 THR 218 218 ?   ?   ?   B . n 
B 2 219 ALA 219 219 ?   ?   ?   B . n 
B 2 220 PRO 220 220 ?   ?   ?   B . n 
B 2 221 VAL 221 221 ?   ?   ?   B . n 
B 2 222 GLY 222 222 ?   ?   ?   B . n 
B 2 223 GLY 223 223 ?   ?   ?   B . n 
B 2 224 PRO 224 224 ?   ?   ?   B . n 
B 2 225 ASP 225 225 ?   ?   ?   B . n 
B 2 226 GLY 226 226 ?   ?   ?   B . n 
B 2 227 THR 227 227 ?   ?   ?   B . n 
B 2 228 VAL 228 228 ?   ?   ?   B . n 
B 2 229 PRO 229 229 ?   ?   ?   B . n 
B 2 230 MET 230 230 ?   ?   ?   B . n 
B 2 231 PRO 231 231 ?   ?   ?   B . n 
B 2 232 MET 232 232 ?   ?   ?   B . n 
B 2 233 PRO 233 233 ?   ?   ?   B . n 
B 2 234 MET 234 234 ?   ?   ?   B . n 
B 2 235 PRO 235 235 ?   ?   ?   B . n 
B 2 236 MET 236 236 ?   ?   ?   B . n 
B 2 237 PRO 237 237 ?   ?   ?   B . n 
B 2 238 SER 238 238 ?   ?   ?   B . n 
B 2 239 ALA 239 239 ?   ?   ?   B . n 
B 2 240 ASN 240 240 ?   ?   ?   B . n 
B 2 241 THR 241 241 ?   ?   ?   B . n 
B 2 242 PRO 242 242 ?   ?   ?   B . n 
B 2 243 PHE 243 243 ?   ?   ?   B . n 
B 2 244 SER 244 244 ?   ?   ?   B . n 
B 2 245 TYR 245 245 ?   ?   ?   B . n 
B 2 246 PRO 246 246 ?   ?   ?   B . n 
B 2 247 LEU 247 247 ?   ?   ?   B . n 
B 2 248 PRO 248 248 ?   ?   ?   B . n 
B 2 249 LYS 249 249 ?   ?   ?   B . n 
B 2 250 GLY 250 250 ?   ?   ?   B . n 
B 2 251 PRO 251 251 ?   ?   ?   B . n 
B 2 252 SER 252 252 ?   ?   ?   B . n 
B 2 253 ASP 253 253 ?   ?   ?   B . n 
B 2 254 PHE 254 254 ?   ?   ?   B . n 
B 2 255 ASN 255 255 ?   ?   ?   B . n 
B 2 256 GLY 256 256 ?   ?   ?   B . n 
B 2 257 LEU 257 257 ?   ?   ?   B . n 
B 2 258 PRO 258 258 ?   ?   ?   B . n 
B 2 259 MET 259 259 ?   ?   ?   B . n 
B 2 260 GLY 260 260 ?   ?   ?   B . n 
B 2 261 THR 261 261 ?   ?   ?   B . n 
B 2 262 TYR 262 262 ?   ?   ?   B . n 
B 2 263 GLN 263 263 ?   ?   ?   B . n 
B 2 264 ALA 264 264 ?   ?   ?   B . n 
B 2 265 PHE 265 265 ?   ?   ?   B . n 
B 2 266 PRO 266 266 ?   ?   ?   B . n 
B 2 267 ASN 267 267 ?   ?   ?   B . n 
B 2 268 ILE 268 268 ?   ?   ?   B . n 
B 2 269 HIS 269 269 ?   ?   ?   B . n 
B 2 270 PRO 270 270 ?   ?   ?   B . n 
B 2 271 PRO 271 271 ?   ?   ?   B . n 
B 2 272 GLN 272 272 ?   ?   ?   B . n 
B 2 273 ILE 273 273 ?   ?   ?   B . n 
B 2 274 PRO 274 274 ?   ?   ?   B . n 
B 2 275 ALA 275 275 ?   ?   ?   B . n 
B 2 276 THR 276 276 ?   ?   ?   B . n 
B 2 277 PRO 277 277 ?   ?   ?   B . n 
B 2 278 PRO 278 278 ?   ?   ?   B . n 
B 2 279 SER 279 279 ?   ?   ?   B . n 
B 2 280 TYR 280 280 ?   ?   ?   B . n 
B 2 281 GLU 281 281 ?   ?   ?   B . n 
B 2 282 SER 282 282 ?   ?   ?   B . n 
B 2 283 VAL 283 283 ?   ?   ?   B . n 
B 2 284 ASP 284 284 ?   ?   ?   B . n 
B 2 285 ASP 285 285 ?   ?   ?   B . n 
B 2 286 ILE 286 286 ?   ?   ?   B . n 
B 2 287 ASN 287 287 ?   ?   ?   B . n 
B 2 288 ALA 288 288 ?   ?   ?   B . n 
B 2 289 ASP 289 289 ?   ?   ?   B . n 
B 2 290 LYS 290 290 ?   ?   ?   B . n 
B 2 291 ASN 291 291 ?   ?   ?   B . n 
B 2 292 ILE 292 292 ?   ?   ?   B . n 
B 2 293 SER 293 293 ?   ?   ?   B . n 
B 2 294 SER 294 294 ?   ?   ?   B . n 
B 2 295 ALA 295 295 ?   ?   ?   B . n 
B 2 296 GLN 296 296 ?   ?   ?   B . n 
B 2 297 ILE 297 297 ?   ?   ?   B . n 
B 2 298 VAL 298 298 ?   ?   ?   B . n 
B 2 299 GLY 299 299 ?   ?   ?   B . n 
B 2 300 PRO 300 300 ?   ?   ?   B . n 
B 2 301 GLY 301 301 ?   ?   ?   B . n 
B 2 302 PRO 302 302 ?   ?   ?   B . n 
B 2 303 LYS 303 303 ?   ?   ?   B . n 
B 2 304 PRO 304 304 ?   ?   ?   B . n 
B 2 305 GLU 305 305 ?   ?   ?   B . n 
B 2 306 ALA 306 306 ?   ?   ?   B . n 
B 2 307 SER 307 307 ?   ?   ?   B . n 
B 2 308 ALA 308 308 ?   ?   ?   B . n 
B 2 309 LYS 309 309 ?   ?   ?   B . n 
B 2 310 LEU 310 310 ?   ?   ?   B . n 
B 2 311 PRO 311 311 ?   ?   ?   B . n 
B 2 312 SER 312 312 ?   ?   ?   B . n 
B 2 313 ARG 313 313 ?   ?   ?   B . n 
B 2 314 PRO 314 314 ?   ?   ?   B . n 
B 2 315 ALA 315 315 ?   ?   ?   B . n 
B 2 316 ASP 316 316 ?   ?   ?   B . n 
B 2 317 ASN 317 317 ?   ?   ?   B . n 
B 2 318 TYR 318 318 ?   ?   ?   B . n 
B 2 319 ASP 319 319 ?   ?   ?   B . n 
B 2 320 ASN 320 320 ?   ?   ?   B . n 
B 2 321 PHE 321 321 ?   ?   ?   B . n 
B 2 322 VAL 322 322 ?   ?   ?   B . n 
B 2 323 LEU 323 323 ?   ?   ?   B . n 
B 2 324 PRO 324 324 ?   ?   ?   B . n 
B 2 325 GLU 325 325 ?   ?   ?   B . n 
B 2 326 LEU 326 326 ?   ?   ?   B . n 
B 2 327 PRO 327 327 ?   ?   ?   B . n 
B 2 328 SER 328 328 ?   ?   ?   B . n 
B 2 329 VAL 329 329 ?   ?   ?   B . n 
B 2 330 PRO 330 330 ?   ?   ?   B . n 
B 2 331 ASP 331 331 ?   ?   ?   B . n 
B 2 332 THR 332 332 ?   ?   ?   B . n 
B 2 333 LEU 333 333 ?   ?   ?   B . n 
B 2 334 PRO 334 334 ?   ?   ?   B . n 
B 2 335 THR 335 335 ?   ?   ?   B . n 
B 2 336 ALA 336 336 ?   ?   ?   B . n 
B 2 337 SER 337 337 ?   ?   ?   B . n 
B 2 338 ALA 338 338 ?   ?   ?   B . n 
B 2 339 GLY 339 339 ?   ?   ?   B . n 
B 2 340 ALA 340 340 ?   ?   ?   B . n 
B 2 341 SER 341 341 ?   ?   ?   B . n 
B 2 342 THR 342 342 ?   ?   ?   B . n 
B 2 343 SER 343 343 ?   ?   ?   B . n 
B 2 344 ALA 344 344 ?   ?   ?   B . n 
B 2 345 SER 345 345 ?   ?   ?   B . n 
B 2 346 GLU 346 346 ?   ?   ?   B . n 
B 2 347 ASP 347 347 ?   ?   ?   B . n 
B 2 348 ILE 348 348 ?   ?   ?   B . n 
B 2 349 ASP 349 349 ?   ?   ?   B . n 
B 2 350 PHE 350 350 ?   ?   ?   B . n 
B 2 351 ASP 351 351 ?   ?   ?   B . n 
B 2 352 ASP 352 352 ?   ?   ?   B . n 
B 2 353 LEU 353 353 ?   ?   ?   B . n 
B 2 354 SER 354 354 ?   ?   ?   B . n 
B 2 355 ARG 355 355 ?   ?   ?   B . n 
B 2 356 ARG 356 356 ?   ?   ?   B . n 
B 2 357 PHE 357 357 ?   ?   ?   B . n 
B 2 358 GLU 358 358 ?   ?   ?   B . n 
B 2 359 GLU 359 359 ?   ?   ?   B . n 
B 2 360 LEU 360 360 ?   ?   ?   B . n 
B 2 361 LYS 361 361 ?   ?   ?   B . n 
B 2 362 LYS 362 362 ?   ?   ?   B . n 
B 2 363 LYS 363 363 ?   ?   ?   B . n 
B 2 364 THR 364 364 ?   ?   ?   B . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8V2S 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8V2S 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8V2S 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8V2S 
_struct.title                        'CHMP1B/IST1 dsDNA bound copolymer' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8V2S 
_struct_keywords.text            'nucleic acid binding, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CHM1B_HUMAN Q7LBR1 ? 1 
;MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQ
TAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEA
GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
;
1 
2 UNP IST1_HUMAN  P53990 ? 2 
;MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLL
ARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKI
LVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDN
FVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
;
1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8V2S A 1 ? 199 ? Q7LBR1 1 ? 199 ? 1 199 
2 2 8V2S B 1 ? 364 ? P53990 1 ? 364 ? 1 364 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8V2S 
_struct_ref_seq_dif.mon_id                       VAL 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      136 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q7LBR1 
_struct_ref_seq_dif.db_mon_id                    MET 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          136 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            136 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   192-meric 
_pdbx_struct_assembly.oligomeric_count     192 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96
;
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                
'Models are deposited as asymmetric units with the helical copies stored in the BIOMTX records.' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'point symmetry operation' ?     ?     -0.93788900 -0.34693600 0.00000000 408.34385 0.34693600  -0.93788900 0.00000000 
284.33517 0.00000000 0.00000000 1.00000000 -30.26000 
2  'point symmetry operation' ?     ?     -0.99998900 -0.00471200 0.00000000 358.28021 0.00471200  -0.99998900 0.00000000 
356.59582 0.00000000 0.00000000 1.00000000 -27.23400 
3  'point symmetry operation' ?     ?     -0.94111700 0.33808100  0.00000000 286.49460 -0.33808100 -0.94111700 0.00000000 
407.33827 0.00000000 0.00000000 1.00000000 -24.20800 
4  'point symmetry operation' ?     ?     -0.76839500 0.63997600  0.00000000 201.67116 -0.63997600 -0.76839500 0.00000000 
430.42403 0.00000000 0.00000000 1.00000000 -21.18200 
5  'point symmetry operation' ?     ?     -0.50271800 0.86445000  0.00000000 114.07124 -0.86445000 -0.50271800 0.00000000 
423.06037 0.00000000 0.00000000 1.00000000 -18.15600 
6  'point symmetry operation' ?     ?     -0.17622600 0.98435000  0.00000000 34.29208  -0.98435000 -0.17622600 0.00000000 
386.13807 0.00000000 0.00000000 1.00000000 -15.13000 
7  'point symmetry operation' ?     ?     0.17158500  0.98516900  0.00000000 -28.01516 -0.98516900 0.17158500  0.00000000 
324.12374 0.00000000 0.00000000 1.00000000 -12.10400 
8  'point symmetry operation' ?     ?     0.49863900  0.86681000  0.00000000 -65.31300 -0.86681000 0.49863900  0.00000000 
244.51947 0.00000000 0.00000000 1.00000000 -9.07800  
9  'point symmetry operation' ?     ?     0.76537100  0.64358900  0.00000000 -73.08939 -0.64358900 0.76537100  0.00000000 
156.95522 0.00000000 0.00000000 1.00000000 -6.05200  
10 'point symmetry operation' ?     ?     0.93951300  0.34251200  0.00000000 -50.40360 -0.34251200 0.93951300  0.00000000 72.02393 
0.00000000 0.00000000 1.00000000 -3.02600  
11 'identity operation'       1_555 x,y,z 1.00000000  0.00000000  0.00000000 0.00000   0.00000000  1.00000000  0.00000000 0.00000 
0.00000000 0.00000000 1.00000000 0.00000   
12 'point symmetry operation' ?     ?     0.93951300  -0.34251200 0.00000000 72.02393  0.34251200  0.93951300  0.00000000 
-50.40360 0.00000000 0.00000000 1.00000000 3.02600   
13 'point symmetry operation' ?     ?     0.76537100  -0.64358900 0.00000000 156.95522 0.64358900  0.76537100  0.00000000 
-73.08939 0.00000000 0.00000000 1.00000000 6.05200   
14 'point symmetry operation' ?     ?     0.49863900  -0.86681000 0.00000000 244.51947 0.86681000  0.49863900  0.00000000 
-65.31300 0.00000000 0.00000000 1.00000000 9.07800   
15 'point symmetry operation' ?     ?     0.17158500  -0.98516900 0.00000000 324.12374 0.98516900  0.17158500  0.00000000 
-28.01516 0.00000000 0.00000000 1.00000000 12.10400  
16 'point symmetry operation' ?     ?     -0.17622600 -0.98435000 0.00000000 386.13807 0.98435000  -0.17622600 0.00000000 34.29208 
0.00000000 0.00000000 1.00000000 15.13000  
17 'point symmetry operation' ?     ?     -0.50271800 -0.86445000 0.00000000 423.06037 0.86445000  -0.50271800 0.00000000 
114.07124 0.00000000 0.00000000 1.00000000 18.15600  
18 'point symmetry operation' ?     ?     -0.76839500 -0.63997600 0.00000000 430.42403 0.63997600  -0.76839500 0.00000000 
201.67116 0.00000000 0.00000000 1.00000000 21.18200  
19 'point symmetry operation' ?     ?     -0.94111700 -0.33808100 0.00000000 407.33827 0.33808100  -0.94111700 0.00000000 
286.49460 0.00000000 0.00000000 1.00000000 24.20800  
20 'point symmetry operation' ?     ?     -0.99998900 0.00471200  0.00000000 356.59582 -0.00471200 -0.99998900 0.00000000 
358.28021 0.00000000 0.00000000 1.00000000 27.23400  
21 'point symmetry operation' ?     ?     -0.93788900 0.34693600  0.00000000 284.33517 -0.34693600 -0.93788900 0.00000000 
408.34385 0.00000000 0.00000000 1.00000000 30.26000  
22 'point symmetry operation' ?     ?     -0.76233000 0.64718900  0.00000000 199.29792 -0.64718900 -0.76233000 0.00000000 
430.62916 0.00000000 0.00000000 1.00000000 33.28600  
23 'point symmetry operation' ?     ?     -0.49454900 0.86915000  0.00000000 111.77129 -0.86915000 -0.49454900 0.00000000 
422.44022 0.00000000 0.00000000 1.00000000 36.31200  
24 'point symmetry operation' ?     ?     -0.16694100 0.98596700  0.00000000 32.34366  -0.98596700 -0.16694100 0.00000000 
384.76767 0.00000000 0.00000000 1.00000000 39.33800  
25 'point symmetry operation' ?     ?     0.18086200  0.98350800  0.00000000 -29.37636 -0.98350800 0.18086200  0.00000000 
322.16888 0.00000000 0.00000000 1.00000000 42.36400  
26 'point symmetry operation' ?     ?     0.50678600  0.86207200  0.00000000 -65.92230 -0.86207200 0.50678600  0.00000000 
242.21662 0.00000000 0.00000000 1.00000000 45.39000  
27 'point symmetry operation' ?     ?     0.77140300  0.63634800  0.00000000 -72.87309 -0.63634800 0.77140300  0.00000000 
154.58298 0.00000000 0.00000000 1.00000000 48.41600  
28 'point symmetry operation' ?     ?     0.94270000  0.33364200  0.00000000 -49.38785 -0.33364200 0.94270000  0.00000000 69.86926 
0.00000000 0.00000000 1.00000000 51.44200  
29 'point symmetry operation' ?     ?     0.99995600  -0.00942500 0.00000000 1.69231   0.00942500  0.99995600  0.00000000 -1.67643 
0.00000000 0.00000000 1.00000000 54.46800  
30 'point symmetry operation' ?     ?     0.93624400  -0.35135100 0.00000000 74.18807  0.35135100  0.93624400  0.00000000 
-51.39900 0.00000000 0.00000000 1.00000000 57.49400  
31 'point symmetry operation' ?     ?     0.75927100  -0.65077400 0.00000000 159.32940 0.65077400  0.75927100  0.00000000 
-73.28334 0.00000000 0.00000000 1.00000000 60.52000  
32 'point symmetry operation' ?     ?     0.49044800  -0.87147100 0.00000000 246.81647 0.87147100  0.49044800  0.00000000 
-64.68203 0.00000000 0.00000000 1.00000000 63.54600  
33 'point symmetry operation' ?     ?     0.16229300  -0.98674300 0.00000000 326.06569 0.98674300  0.16229300  0.00000000 
-26.63561 0.00000000 0.00000000 1.00000000 66.57200  
34 'point symmetry operation' ?     ?     -0.18549500 -0.98264500 0.00000000 387.49003 0.98264500  -0.18549500 0.00000000 36.25334 
0.00000000 0.00000000 1.00000000 69.59800  
35 'point symmetry operation' ?     ?     -0.51084300 -0.85967400 0.00000000 423.65881 0.85967400  -0.51084300 0.00000000 
116.37693 0.00000000 0.00000000 1.00000000 72.62400  
36 'point symmetry operation' ?     ?     -0.77439300 -0.63270500 0.00000000 430.19655 0.63270500  -0.77439300 0.00000000 
204.04236 0.00000000 0.00000000 1.00000000 75.65000  
37 'point symmetry operation' ?     ?     -0.94426200 -0.32919600 0.00000000 406.31238 0.32919600  -0.94426200 0.00000000 
288.64446 0.00000000 0.00000000 1.00000000 78.67600  
38 'point symmetry operation' ?     ?     -0.99990000 0.01413700  0.00000000 354.89563 -0.01413700 -0.99990000 0.00000000 
359.94865 0.00000000 0.00000000 1.00000000 81.70200  
39 'point symmetry operation' ?     ?     -0.93457800 0.35576000  0.00000000 282.16636 -0.35576000 -0.93457800 0.00000000 
409.32904 0.00000000 0.00000000 1.00000000 84.72800  
40 'point symmetry operation' ?     ?     -0.75619600 0.65434500  0.00000000 196.92285 -0.65434500 -0.75619600 0.00000000 
430.81191 0.00000000 0.00000000 1.00000000 87.75400  
41 'point symmetry operation' ?     ?     -0.48633500 0.87377200  0.00000000 109.47729 -0.87377200 -0.48633500 0.00000000 
421.79843 0.00000000 0.00000000 1.00000000 90.78000  
42 'point symmetry operation' ?     ?     -0.15764100 0.98749600  0.00000000 30.40823  -0.98749600 -0.15764100 0.00000000 
383.37898 0.00000000 0.00000000 1.00000000 93.80600  
43 'point symmetry operation' ?     ?     0.19012400  0.98176000  0.00000000 -30.71907 -0.98176000 0.19012400  0.00000000 
320.20128 0.00000000 0.00000000 1.00000000 96.83200  
44 'point symmetry operation' ?     ?     0.51488800  0.85725700  0.00000000 -66.50987 -0.85725700 0.51488800  0.00000000 
239.90814 0.00000000 0.00000000 1.00000000 99.85800  
45 'point symmetry operation' ?     ?     0.77736600  0.62904900  0.00000000 -72.63443 -0.62904900 0.77736600  0.00000000 
152.21287 0.00000000 0.00000000 1.00000000 102.88400 
46 'point symmetry operation' ?     ?     0.94580200  0.32474300  0.00000000 -48.35184 -0.32474300 0.94580200  0.00000000 67.72426 
0.00000000 0.00000000 1.00000000 105.91000 
47 'point symmetry operation' ?     ?     0.99982200  -0.01884800 0.00000000 3.40034   0.01884800  0.99982200  0.00000000 -3.33684 
0.00000000 0.00000000 1.00000000 108.93600 
48 'point symmetry operation' ?     ?     0.93289100  -0.36016000 0.00000000 76.36151  0.36016000  0.93289100  0.00000000 
-52.37395 0.00000000 0.00000000 1.00000000 111.96200 
49 'point symmetry operation' ?     ?     0.75310400  -0.65790100 0.00000000 161.70530 0.65790100  0.75310400  0.00000000 
-73.45489 0.00000000 0.00000000 1.00000000 114.98800 
50 'point symmetry operation' ?     ?     0.48221200  -0.87605400 0.00000000 249.10742 0.87605400  0.48221200  0.00000000 
-64.02943 0.00000000 0.00000000 1.00000000 118.01400 
51 'point symmetry operation' ?     ?     0.15298600  -0.98822800 0.00000000 327.99455 0.98822800  0.15298600  0.00000000 
-25.23780 0.00000000 0.00000000 1.00000000 121.04000 
52 'point symmetry operation' ?     ?     -0.19474800 -0.98085300 0.00000000 388.82346 0.98085300  -0.19474800 0.00000000 38.22725 
0.00000000 0.00000000 1.00000000 124.06600 
53 'point symmetry operation' ?     ?     -0.51892200 -0.85482100 0.00000000 424.23549 0.85482100  -0.51892200 0.00000000 
118.68816 0.00000000 0.00000000 1.00000000 127.09200 
54 'point symmetry operation' ?     ?     -0.78032100 -0.62537900 0.00000000 429.94673 0.62537900  -0.78032100 0.00000000 
206.41131 0.00000000 0.00000000 1.00000000 130.11800 
55 'point symmetry operation' ?     ?     -0.94732200 -0.32028200 0.00000000 405.26627 0.32028200  -0.94732200 0.00000000 
290.78455 0.00000000 0.00000000 1.00000000 133.14400 
56 'point symmetry operation' ?     ?     -0.99972200 0.02356000  0.00000000 353.17979 -0.02356000 -0.99972200 0.00000000 
361.60099 0.00000000 0.00000000 1.00000000 136.17000 
57 'point symmetry operation' ?     ?     -0.93118300 0.36455200  0.00000000 279.98836 -0.36455200 -0.93118300 0.00000000 
410.29374 0.00000000 0.00000000 1.00000000 139.19600 
58 'point symmetry operation' ?     ?     -0.74999600 0.66144300  0.00000000 194.54617 -0.66144300 -0.74999600 0.00000000 
430.97227 0.00000000 0.00000000 1.00000000 142.22200 
59 'point symmetry operation' ?     ?     -0.47807900 0.87831700  0.00000000 107.18944 -0.87831700 -0.47807900 0.00000000 
421.13505 0.00000000 0.00000000 1.00000000 145.24800 
60 'point symmetry operation' ?     ?     -0.14832700 0.98893800  0.00000000 28.48598  -0.98893800 -0.14832700 0.00000000 
381.97210 0.00000000 0.00000000 1.00000000 148.27400 
61 'point symmetry operation' ?     ?     0.19936800  0.97992500  0.00000000 -32.04318 -0.97992500 0.19936800  0.00000000 
318.22111 0.00000000 0.00000000 1.00000000 151.30000 
62 'point symmetry operation' ?     ?     0.52294500  0.85236600  0.00000000 -67.07565 -0.85236600 0.52294500  0.00000000 
237.59422 0.00000000 0.00000000 1.00000000 154.32600 
63 'point symmetry operation' ?     ?     0.78326000  0.62169500  0.00000000 -72.37345 -0.62169500 0.78326000  0.00000000 
149.84513 0.00000000 0.00000000 1.00000000 157.35200 
64 'point symmetry operation' ?     ?     0.94882100  0.31581500  0.00000000 -47.29567 -0.31581500 0.94882100  0.00000000 65.58912 
0.00000000 0.00000000 1.00000000 160.37800 
65 'point symmetry operation' ?     ?     0.99960000  -0.02827100 0.00000000 5.12395   0.02827100  0.99960000  0.00000000 -4.98108 
0.00000000 0.00000000 1.00000000 163.40400 
66 'point symmetry operation' ?     ?     0.92945500  -0.36893600 0.00000000 78.54403  0.36893600  0.92945500  0.00000000 
-53.32838 0.00000000 0.00000000 1.00000000 166.43000 
67 'point symmetry operation' ?     ?     0.74687000  -0.66497000 0.00000000 164.08271 0.66497000  0.74687000  0.00000000 
-73.60405 0.00000000 0.00000000 1.00000000 169.45600 
68 'point symmetry operation' ?     ?     0.47393500  -0.88056000 0.00000000 251.39212 0.88056000  0.47393500  0.00000000 
-63.35528 0.00000000 0.00000000 1.00000000 172.48200 
69 'point symmetry operation' ?     ?     0.14366500  -0.98962600 0.00000000 329.91015 0.98962600  0.14366500  0.00000000 
-23.82189 0.00000000 0.00000000 1.00000000 175.50800 
70 'point symmetry operation' ?     ?     -0.20398300 -0.97897400 0.00000000 390.13822 0.97897400  -0.20398300 0.00000000 40.21364 
0.00000000 0.00000000 1.00000000 178.53400 
71 'point symmetry operation' ?     ?     -0.52695600 -0.84989300 0.00000000 424.79036 0.84989300  -0.52695600 0.00000000 
121.00472 0.00000000 0.00000000 1.00000000 181.56000 
72 'point symmetry operation' ?     ?     -0.78618100 -0.61799700 0.00000000 429.67459 0.61799700  -0.78618100 0.00000000 
208.77780 0.00000000 0.00000000 1.00000000 184.58600 
73 'point symmetry operation' ?     ?     -0.95029900 -0.31134000 0.00000000 404.20004 0.31134000  -0.95029900 0.00000000 
292.91469 0.00000000 0.00000000 1.00000000 187.61200 
74 'point symmetry operation' ?     ?     -0.99945600 0.03298100  0.00000000 351.44846 -0.03298100 -0.99945600 0.00000000 
363.23709 0.00000000 0.00000000 1.00000000 190.63800 
75 'point symmetry operation' ?     ?     -0.92770600 0.37331200  0.00000000 277.80136 -0.37331200 -0.92770600 0.00000000 
411.23787 0.00000000 0.00000000 1.00000000 193.66400 
76 'point symmetry operation' ?     ?     -0.74372800 0.66848200  0.00000000 192.16808 -0.66848200 -0.74372800 0.00000000 
431.11023 0.00000000 0.00000000 1.00000000 196.69000 
77 'point symmetry operation' ?     ?     -0.46978000 0.88278400  0.00000000 104.90794 -0.88278400 -0.46978000 0.00000000 
420.45013 0.00000000 0.00000000 1.00000000 199.71600 
78 'point symmetry operation' ?     ?     -0.13900000 0.99029200  0.00000000 26.57708  -0.99029200 -0.13900000 0.00000000 
380.54717 0.00000000 0.00000000 1.00000000 202.74200 
79 'point symmetry operation' ?     ?     0.20859500  0.97800200  0.00000000 -33.34857 -0.97800200 0.20859500  0.00000000 
316.22854 0.00000000 0.00000000 1.00000000 205.76800 
80 'point symmetry operation' ?     ?     0.53095500  0.84740000  0.00000000 -67.61961 -0.84740000 0.53095500  0.00000000 
235.27507 0.00000000 0.00000000 1.00000000 208.79400 
81 'point symmetry operation' ?     ?     0.78908400  0.61428500  0.00000000 -72.09016 -0.61428500 0.78908400  0.00000000 
147.47994 0.00000000 0.00000000 1.00000000 211.82000 
82 'point symmetry operation' ?     ?     0.95175500  0.30685800  0.00000000 -46.21941 -0.30685800 0.95175500  0.00000000 63.46403 
0.00000000 0.00000000 1.00000000 214.84600 
83 'point symmetry operation' ?     ?     0.99928900  -0.03769000 0.00000000 6.86297   0.03769000  0.99928900  0.00000000 -6.60900 
0.00000000 0.00000000 1.00000000 217.87200 
84 'point symmetry operation' ?     ?     0.92593700  -0.37767900 0.00000000 80.73545  0.37767900  0.92593700  0.00000000 
-54.26220 0.00000000 0.00000000 1.00000000 220.89800 
85 'point symmetry operation' ?     ?     0.74057000  -0.67197900 0.00000000 166.46143 0.67197900  0.74057000  0.00000000 
-73.73080 0.00000000 0.00000000 1.00000000 223.92400 
86 'point symmetry operation' ?     ?     0.46561500  -0.88498800 0.00000000 253.67036 0.88498800  0.46561500  0.00000000 
-62.65962 0.00000000 0.00000000 1.00000000 226.95000 
87 'point symmetry operation' ?     ?     0.13433200  -0.99093600 0.00000000 331.81232 0.99093600  0.13433200  0.00000000 
-22.38798 0.00000000 0.00000000 1.00000000 229.97600 
88 'point symmetry operation' ?     ?     -0.21320100 -0.97700800 0.00000000 391.43420 0.97700800  -0.21320100 0.00000000 42.21233 
0.00000000 0.00000000 1.00000000 233.00200 
89 'point symmetry operation' ?     ?     -0.53494200 -0.84488900 0.00000000 425.32338 0.84488900  -0.53494200 0.00000000 
123.32641 0.00000000 0.00000000 1.00000000 236.02800 
90 'point symmetry operation' ?     ?     -0.79197000 -0.61056000 0.00000000 429.38016 0.61056000  -0.79197000 0.00000000 
211.14162 0.00000000 0.00000000 1.00000000 239.05400 
91 'point symmetry operation' ?     ?     -0.95319100 -0.30237000 0.00000000 403.11378 0.30237000  -0.95319100 0.00000000 
295.03469 0.00000000 0.00000000 1.00000000 242.08000 
92 'point symmetry operation' ?     ?     -0.99910100 0.04239900  0.00000000 349.70178 -0.04239900 -0.99910100 0.00000000 
364.85680 0.00000000 0.00000000 1.00000000 245.10600 
93 'point symmetry operation' ?     ?     -0.92414600 0.38203800  0.00000000 275.60556 -0.38203800 -0.92414600 0.00000000 
412.16135 0.00000000 0.00000000 1.00000000 248.13200 
94 'point symmetry operation' ?     ?     -0.73739500 0.67546200  0.00000000 189.78879 -0.67546200 -0.73739500 0.00000000 
431.22576 0.00000000 0.00000000 1.00000000 251.15800 
95 'point symmetry operation' ?     ?     -0.46143900 0.88717200  0.00000000 102.63300 -0.88717200 -0.46143900 0.00000000 
419.74374 0.00000000 0.00000000 1.00000000 254.18400 
96 'point symmetry operation' ?     ?     -0.12966100 0.99155800  0.00000000 24.68169  -0.99155800 -0.12966100 0.00000000 
379.10432 0.00000000 0.00000000 1.00000000 257.21000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 2   ? LYS A 42  ? SER A 2   LYS A 42  1 ? 41 
HELX_P HELX_P2  AA2 ASN A 44  ? MET A 106 ? ASN A 44  MET A 106 1 ? 63 
HELX_P HELX_P3  AA3 ASN A 107 ? THR A 140 ? ASN A 107 THR A 140 1 ? 34 
HELX_P HELX_P4  AA4 THR A 141 ? THR A 144 ? THR A 141 THR A 144 5 ? 4  
HELX_P HELX_P5  AA5 PRO A 145 ? GLY A 161 ? PRO A 145 GLY A 161 1 ? 17 
HELX_P HELX_P6  AA6 GLU A 187 ? VAL A 199 ? GLU A 187 VAL A 199 1 ? 13 
HELX_P HELX_P7  AA7 LYS B 7   ? ALA B 45  ? LYS B 7   ALA B 45  1 ? 39 
HELX_P HELX_P8  AA8 LYS B 48  ? ARG B 82  ? LYS B 48  ARG B 82  1 ? 35 
HELX_P HELX_P9  AA9 ARG B 82  ? GLN B 87  ? ARG B 82  GLN B 87  1 ? 6  
HELX_P HELX_P10 AB1 LEU B 96  ? GLN B 111 ? LEU B 96  GLN B 111 1 ? 16 
HELX_P HELX_P11 AB2 VAL B 114 ? TYR B 128 ? VAL B 114 TYR B 128 1 ? 15 
HELX_P HELX_P12 AB3 SER B 129 ? THR B 138 ? SER B 129 THR B 138 1 ? 10 
HELX_P HELX_P13 AB4 ASN B 145 ? LYS B 151 ? ASN B 145 LYS B 151 1 ? 7  
HELX_P HELX_P14 AB5 PRO B 158 ? TYR B 173 ? PRO B 158 TYR B 173 1 ? 16 
HELX_P HELX_P15 AB6 ASP B 180 ? ALA B 187 ? ASP B 180 ALA B 187 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8V2S 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 140 ? ? -99.32 33.38  
2 1 SER B 129 ? ? 81.50  142.05 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 78 ? ? 0.091 'SIDE CHAIN' 
2 1 ARG B 53 ? ? 0.102 'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8V2S 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      OTHER 
# 
loop_
_em_3d_fitting_list.id 
_em_3d_fitting_list.3d_fitting_id 
_em_3d_fitting_list.pdb_entry_id 
_em_3d_fitting_list.pdb_chain_id 
_em_3d_fitting_list.pdb_chain_residue_range 
_em_3d_fitting_list.details 
_em_3d_fitting_list.chain_id 
_em_3d_fitting_list.chain_residue_range 
_em_3d_fitting_list.source_name 
_em_3d_fitting_list.type 
_em_3d_fitting_list.accession_code 
_em_3d_fitting_list.initial_refinement_model_id 
1 1 6TZ4 A ? 'Isolated CHMP1B monomer for each biological unit used as initial model' A ? PDB 'experimental model' 6TZ4 1 
2 1 3FRR B ? 'Isolated IST1 monomer for each biological unit used as initial model'   B ? PDB 'experimental model' 3FRR 2 
# 
_em_3d_reconstruction.entry_id                    8V2S 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'FOURIER SPACE' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.72 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               451289 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          10 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               HELICAL 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 RECOMBINANT COMPLEX 'CHMP1B/IST1 copolymer bound to a 60-mer oligonucleotide of ssDNA' 
;Complex assembly formed my mixing protein and oligonucleotide at a 1:20 molar ratio (protein to base) by dialysis into physiological buffer conditions
;
? ? '1, 2' 
2 1 RECOMBINANT COMPLEX 'Charged multivesicular body protein 1B (CHMP1B)'                  
'CHMP1B component of the nucleic acid templated helical assembly' ? ? 1      
3 1 RECOMBINANT COMPLEX 'Increased sodium tolerance 1 (IST1)'                              
'IST1 component of the nucleic acid templated assembly' ? ? 2      
# 
_em_imaging.entry_id                        8V2S 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS GLACIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           OTHER 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            200 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1800 
_em_imaging.calibrated_defocus_min          100 
_em_imaging.calibrated_defocus_max          4000 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            50.0 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.citation_id      ? 
_em_sample_support.details          ? 
_em_sample_support.film_material    ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R0.6/1' 
_em_sample_support.id               1 
_em_sample_support.method           ? 
_em_sample_support.specimen_id      1 
# 
_em_vitrification.entry_id              8V2S 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   292.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8V2S 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.aggregation_state       FILAMENT 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 171 ? A GLY 171 
2   1 Y 1 A GLN 172 ? A GLN 172 
3   1 Y 1 A THR 173 ? A THR 173 
4   1 Y 1 A GLY 174 ? A GLY 174 
5   1 Y 1 A SER 175 ? A SER 175 
6   1 Y 1 A VAL 176 ? A VAL 176 
7   1 Y 1 A GLY 177 ? A GLY 177 
8   1 Y 1 A THR 178 ? A THR 178 
9   1 Y 1 A SER 179 ? A SER 179 
10  1 Y 1 A VAL 180 ? A VAL 180 
11  1 Y 1 A ALA 181 ? A ALA 181 
12  1 Y 1 A SER 182 ? A SER 182 
13  1 Y 1 A ALA 183 ? A ALA 183 
14  1 Y 1 A GLU 184 ? A GLU 184 
15  1 Y 1 A GLN 185 ? A GLN 185 
16  1 Y 1 B MET 1   ? B MET 1   
17  1 Y 1 B LEU 2   ? B LEU 2   
18  1 Y 1 B GLY 3   ? B GLY 3   
19  1 Y 1 B PRO 188 ? B PRO 188 
20  1 Y 1 B PRO 189 ? B PRO 189 
21  1 Y 1 B GLY 190 ? B GLY 190 
22  1 Y 1 B VAL 191 ? B VAL 191 
23  1 Y 1 B GLU 192 ? B GLU 192 
24  1 Y 1 B THR 193 ? B THR 193 
25  1 Y 1 B ASP 194 ? B ASP 194 
26  1 Y 1 B LEU 195 ? B LEU 195 
27  1 Y 1 B ILE 196 ? B ILE 196 
28  1 Y 1 B ASP 197 ? B ASP 197 
29  1 Y 1 B VAL 198 ? B VAL 198 
30  1 Y 1 B GLY 199 ? B GLY 199 
31  1 Y 1 B PHE 200 ? B PHE 200 
32  1 Y 1 B THR 201 ? B THR 201 
33  1 Y 1 B ASP 202 ? B ASP 202 
34  1 Y 1 B ASP 203 ? B ASP 203 
35  1 Y 1 B VAL 204 ? B VAL 204 
36  1 Y 1 B LYS 205 ? B LYS 205 
37  1 Y 1 B LYS 206 ? B LYS 206 
38  1 Y 1 B GLY 207 ? B GLY 207 
39  1 Y 1 B GLY 208 ? B GLY 208 
40  1 Y 1 B PRO 209 ? B PRO 209 
41  1 Y 1 B GLY 210 ? B GLY 210 
42  1 Y 1 B ARG 211 ? B ARG 211 
43  1 Y 1 B GLY 212 ? B GLY 212 
44  1 Y 1 B GLY 213 ? B GLY 213 
45  1 Y 1 B SER 214 ? B SER 214 
46  1 Y 1 B GLY 215 ? B GLY 215 
47  1 Y 1 B GLY 216 ? B GLY 216 
48  1 Y 1 B PHE 217 ? B PHE 217 
49  1 Y 1 B THR 218 ? B THR 218 
50  1 Y 1 B ALA 219 ? B ALA 219 
51  1 Y 1 B PRO 220 ? B PRO 220 
52  1 Y 1 B VAL 221 ? B VAL 221 
53  1 Y 1 B GLY 222 ? B GLY 222 
54  1 Y 1 B GLY 223 ? B GLY 223 
55  1 Y 1 B PRO 224 ? B PRO 224 
56  1 Y 1 B ASP 225 ? B ASP 225 
57  1 Y 1 B GLY 226 ? B GLY 226 
58  1 Y 1 B THR 227 ? B THR 227 
59  1 Y 1 B VAL 228 ? B VAL 228 
60  1 Y 1 B PRO 229 ? B PRO 229 
61  1 Y 1 B MET 230 ? B MET 230 
62  1 Y 1 B PRO 231 ? B PRO 231 
63  1 Y 1 B MET 232 ? B MET 232 
64  1 Y 1 B PRO 233 ? B PRO 233 
65  1 Y 1 B MET 234 ? B MET 234 
66  1 Y 1 B PRO 235 ? B PRO 235 
67  1 Y 1 B MET 236 ? B MET 236 
68  1 Y 1 B PRO 237 ? B PRO 237 
69  1 Y 1 B SER 238 ? B SER 238 
70  1 Y 1 B ALA 239 ? B ALA 239 
71  1 Y 1 B ASN 240 ? B ASN 240 
72  1 Y 1 B THR 241 ? B THR 241 
73  1 Y 1 B PRO 242 ? B PRO 242 
74  1 Y 1 B PHE 243 ? B PHE 243 
75  1 Y 1 B SER 244 ? B SER 244 
76  1 Y 1 B TYR 245 ? B TYR 245 
77  1 Y 1 B PRO 246 ? B PRO 246 
78  1 Y 1 B LEU 247 ? B LEU 247 
79  1 Y 1 B PRO 248 ? B PRO 248 
80  1 Y 1 B LYS 249 ? B LYS 249 
81  1 Y 1 B GLY 250 ? B GLY 250 
82  1 Y 1 B PRO 251 ? B PRO 251 
83  1 Y 1 B SER 252 ? B SER 252 
84  1 Y 1 B ASP 253 ? B ASP 253 
85  1 Y 1 B PHE 254 ? B PHE 254 
86  1 Y 1 B ASN 255 ? B ASN 255 
87  1 Y 1 B GLY 256 ? B GLY 256 
88  1 Y 1 B LEU 257 ? B LEU 257 
89  1 Y 1 B PRO 258 ? B PRO 258 
90  1 Y 1 B MET 259 ? B MET 259 
91  1 Y 1 B GLY 260 ? B GLY 260 
92  1 Y 1 B THR 261 ? B THR 261 
93  1 Y 1 B TYR 262 ? B TYR 262 
94  1 Y 1 B GLN 263 ? B GLN 263 
95  1 Y 1 B ALA 264 ? B ALA 264 
96  1 Y 1 B PHE 265 ? B PHE 265 
97  1 Y 1 B PRO 266 ? B PRO 266 
98  1 Y 1 B ASN 267 ? B ASN 267 
99  1 Y 1 B ILE 268 ? B ILE 268 
100 1 Y 1 B HIS 269 ? B HIS 269 
101 1 Y 1 B PRO 270 ? B PRO 270 
102 1 Y 1 B PRO 271 ? B PRO 271 
103 1 Y 1 B GLN 272 ? B GLN 272 
104 1 Y 1 B ILE 273 ? B ILE 273 
105 1 Y 1 B PRO 274 ? B PRO 274 
106 1 Y 1 B ALA 275 ? B ALA 275 
107 1 Y 1 B THR 276 ? B THR 276 
108 1 Y 1 B PRO 277 ? B PRO 277 
109 1 Y 1 B PRO 278 ? B PRO 278 
110 1 Y 1 B SER 279 ? B SER 279 
111 1 Y 1 B TYR 280 ? B TYR 280 
112 1 Y 1 B GLU 281 ? B GLU 281 
113 1 Y 1 B SER 282 ? B SER 282 
114 1 Y 1 B VAL 283 ? B VAL 283 
115 1 Y 1 B ASP 284 ? B ASP 284 
116 1 Y 1 B ASP 285 ? B ASP 285 
117 1 Y 1 B ILE 286 ? B ILE 286 
118 1 Y 1 B ASN 287 ? B ASN 287 
119 1 Y 1 B ALA 288 ? B ALA 288 
120 1 Y 1 B ASP 289 ? B ASP 289 
121 1 Y 1 B LYS 290 ? B LYS 290 
122 1 Y 1 B ASN 291 ? B ASN 291 
123 1 Y 1 B ILE 292 ? B ILE 292 
124 1 Y 1 B SER 293 ? B SER 293 
125 1 Y 1 B SER 294 ? B SER 294 
126 1 Y 1 B ALA 295 ? B ALA 295 
127 1 Y 1 B GLN 296 ? B GLN 296 
128 1 Y 1 B ILE 297 ? B ILE 297 
129 1 Y 1 B VAL 298 ? B VAL 298 
130 1 Y 1 B GLY 299 ? B GLY 299 
131 1 Y 1 B PRO 300 ? B PRO 300 
132 1 Y 1 B GLY 301 ? B GLY 301 
133 1 Y 1 B PRO 302 ? B PRO 302 
134 1 Y 1 B LYS 303 ? B LYS 303 
135 1 Y 1 B PRO 304 ? B PRO 304 
136 1 Y 1 B GLU 305 ? B GLU 305 
137 1 Y 1 B ALA 306 ? B ALA 306 
138 1 Y 1 B SER 307 ? B SER 307 
139 1 Y 1 B ALA 308 ? B ALA 308 
140 1 Y 1 B LYS 309 ? B LYS 309 
141 1 Y 1 B LEU 310 ? B LEU 310 
142 1 Y 1 B PRO 311 ? B PRO 311 
143 1 Y 1 B SER 312 ? B SER 312 
144 1 Y 1 B ARG 313 ? B ARG 313 
145 1 Y 1 B PRO 314 ? B PRO 314 
146 1 Y 1 B ALA 315 ? B ALA 315 
147 1 Y 1 B ASP 316 ? B ASP 316 
148 1 Y 1 B ASN 317 ? B ASN 317 
149 1 Y 1 B TYR 318 ? B TYR 318 
150 1 Y 1 B ASP 319 ? B ASP 319 
151 1 Y 1 B ASN 320 ? B ASN 320 
152 1 Y 1 B PHE 321 ? B PHE 321 
153 1 Y 1 B VAL 322 ? B VAL 322 
154 1 Y 1 B LEU 323 ? B LEU 323 
155 1 Y 1 B PRO 324 ? B PRO 324 
156 1 Y 1 B GLU 325 ? B GLU 325 
157 1 Y 1 B LEU 326 ? B LEU 326 
158 1 Y 1 B PRO 327 ? B PRO 327 
159 1 Y 1 B SER 328 ? B SER 328 
160 1 Y 1 B VAL 329 ? B VAL 329 
161 1 Y 1 B PRO 330 ? B PRO 330 
162 1 Y 1 B ASP 331 ? B ASP 331 
163 1 Y 1 B THR 332 ? B THR 332 
164 1 Y 1 B LEU 333 ? B LEU 333 
165 1 Y 1 B PRO 334 ? B PRO 334 
166 1 Y 1 B THR 335 ? B THR 335 
167 1 Y 1 B ALA 336 ? B ALA 336 
168 1 Y 1 B SER 337 ? B SER 337 
169 1 Y 1 B ALA 338 ? B ALA 338 
170 1 Y 1 B GLY 339 ? B GLY 339 
171 1 Y 1 B ALA 340 ? B ALA 340 
172 1 Y 1 B SER 341 ? B SER 341 
173 1 Y 1 B THR 342 ? B THR 342 
174 1 Y 1 B SER 343 ? B SER 343 
175 1 Y 1 B ALA 344 ? B ALA 344 
176 1 Y 1 B SER 345 ? B SER 345 
177 1 Y 1 B GLU 346 ? B GLU 346 
178 1 Y 1 B ASP 347 ? B ASP 347 
179 1 Y 1 B ILE 348 ? B ILE 348 
180 1 Y 1 B ASP 349 ? B ASP 349 
181 1 Y 1 B PHE 350 ? B PHE 350 
182 1 Y 1 B ASP 351 ? B ASP 351 
183 1 Y 1 B ASP 352 ? B ASP 352 
184 1 Y 1 B LEU 353 ? B LEU 353 
185 1 Y 1 B SER 354 ? B SER 354 
186 1 Y 1 B ARG 355 ? B ARG 355 
187 1 Y 1 B ARG 356 ? B ARG 356 
188 1 Y 1 B PHE 357 ? B PHE 357 
189 1 Y 1 B GLU 358 ? B GLU 358 
190 1 Y 1 B GLU 359 ? B GLU 359 
191 1 Y 1 B LEU 360 ? B LEU 360 
192 1 Y 1 B LYS 361 ? B LYS 361 
193 1 Y 1 B LYS 362 ? B LYS 362 
194 1 Y 1 B LYS 363 ? B LYS 363 
195 1 Y 1 B THR 364 ? B THR 364 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-11-23 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8V2S 
_em_admin.last_update        2024-11-27 
_em_admin.map_release_date   2024-11-27 
_em_admin.title              'CHMP1B/IST1 dsDNA bound copolymer' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 50  mM Tris-HCl 1 'Tris Hydrochloride' 
1 125 mM NaCl     2 'Sodium Chloride'    
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
loop_
_em_entity_assembly_molwt.entity_assembly_id 
_em_entity_assembly_molwt.experimental_flag 
_em_entity_assembly_molwt.id 
_em_entity_assembly_molwt.units 
_em_entity_assembly_molwt.value 
1 NO  1 ?           ?        
1 YES 2 MEGADALTONS 0.220762 
1 YES 3 MEGADALTONS 0.397494 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 1 2 9606 'Homo sapiens' ? ? ? ? ? 
? ? 2 3 9606 'Homo sapiens' ? ? ? ? ? 
? ? 3 4 9606 'Homo sapiens' ? ? ? ? ? 
# 
loop_
_em_entity_assembly_recombinant.cell 
_em_entity_assembly_recombinant.entity_assembly_id 
_em_entity_assembly_recombinant.id 
_em_entity_assembly_recombinant.ncbi_tax_id 
_em_entity_assembly_recombinant.organism 
_em_entity_assembly_recombinant.plasmid 
_em_entity_assembly_recombinant.strain 
? 1 2 469008 'Escherichia coli BL21(DE3)' pET28 ? 
? 2 3 469008 'Escherichia coli BL21(DE3)' pET28 ? 
? 3 4 469008 'Escherichia coli BL21(DE3)' pET28 ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.details                        ? 
_em_helical_entity.axial_symmetry                 C1 
_em_helical_entity.angular_rotation_per_subunit   3.025 
_em_helical_entity.axial_rise_per_subunit         2.72 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    10 
_em_imaging_optics.energyfilter_name          'TFS Selectris' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   511337 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? cryoSPARC 4.2.1  
'IMAGE ACQUISITION'        ? 2  ? ? 1 EPU       3.4    
MASKING                    ? 3  ? ? ? ?         ?      
'CTF CORRECTION'           ? 4  1 ? ? cryoSPARC 4.2.1  
'LAYERLINE INDEXING'       ? 5  ? ? ? ?         ?      
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?         ?      
'MODEL FITTING'            ? 7  ? 1 ? ISOLDE    1.6.0  
OTHER                      ? 8  ? ? ? ?         ?      
'MODEL REFINEMENT'         ? 9  ? 1 ? ISOLDE    1.6.0  
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? cryoSPARC 4.2.1  
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? cryoSPARC V4.2.1 
CLASSIFICATION             ? 12 1 ? ? cryoSPARC 4.2.1  
RECONSTRUCTION             ? 13 1 ? ? cryoSPARC 4.2.1  
# 
_em_specimen.concentration           ? 
_em_specimen.details                 'Sample is at 16 micromolar protein concentration.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/Office of the Director'                                     'United States' S10OD020054     1 
'National Institutes of Health/Office of the Director'                                     'United States' 1S10OD021741    2 
'National Institutes of Health/Office of the Director'                                     'United States' 1S10OD021596-01 3 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 1DP2GM110772-01 4 
'Howard Hughes Medical Institute (HHMI)'                                                   'United States' ?               5 
'Chan Zuckerberg Initiative'                                                               'United States' ?               6 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
1 'experimental model' PDB 6TZ4 
2 'experimental model' PDB 3FRR 
# 
_atom_sites.entry_id                    8V2S 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . MET A 1 1   ? 153.672 236.562 86.040 1.00 84.97  ? 1   MET A N   1 
ATOM 2    C CA  . MET A 1 1   ? 152.272 236.956 85.721 1.00 80.57  ? 1   MET A CA  1 
ATOM 3    C C   . MET A 1 1   ? 151.814 237.959 86.773 1.00 75.82  ? 1   MET A C   1 
ATOM 4    O O   . MET A 1 1   ? 151.384 237.578 87.861 1.00 76.90  ? 1   MET A O   1 
ATOM 5    C CB  . MET A 1 1   ? 151.335 235.739 85.697 1.00 82.47  ? 1   MET A CB  1 
ATOM 6    C CG  . MET A 1 1   ? 149.885 236.067 85.360 1.00 80.33  ? 1   MET A CG  1 
ATOM 7    S SD  . MET A 1 1   ? 149.524 236.319 83.607 1.00 84.41  ? 1   MET A SD  1 
ATOM 8    C CE  . MET A 1 1   ? 149.234 234.613 83.101 1.00 90.92  ? 1   MET A CE  1 
ATOM 9    N N   . SER A 1 2   ? 151.932 239.238 86.410 1.00 75.33  ? 2   SER A N   1 
ATOM 10   C CA  . SER A 1 2   ? 151.389 240.348 87.166 1.00 69.70  ? 2   SER A CA  1 
ATOM 11   C C   . SER A 1 2   ? 149.885 240.197 87.392 1.00 71.33  ? 2   SER A C   1 
ATOM 12   O O   . SER A 1 2   ? 149.195 239.442 86.718 1.00 72.12  ? 2   SER A O   1 
ATOM 13   C CB  . SER A 1 2   ? 151.670 241.611 86.424 1.00 72.40  ? 2   SER A CB  1 
ATOM 14   O OG  . SER A 1 2   ? 150.893 242.692 86.928 1.00 71.38  ? 2   SER A OG  1 
ATOM 15   N N   . ASN A 1 3   ? 149.347 241.007 88.293 1.00 73.48  ? 3   ASN A N   1 
ATOM 16   C CA  . ASN A 1 3   ? 147.919 241.069 88.535 1.00 69.80  ? 3   ASN A CA  1 
ATOM 17   C C   . ASN A 1 3   ? 147.163 241.537 87.291 1.00 68.79  ? 3   ASN A C   1 
ATOM 18   O O   . ASN A 1 3   ? 146.124 240.979 86.971 1.00 68.50  ? 3   ASN A O   1 
ATOM 19   C CB  . ASN A 1 3   ? 147.663 242.011 89.698 1.00 73.89  ? 3   ASN A CB  1 
ATOM 20   C CG  . ASN A 1 3   ? 146.510 241.569 90.551 1.00 76.21  ? 3   ASN A CG  1 
ATOM 21   O OD1 . ASN A 1 3   ? 146.505 240.416 91.006 1.00 78.76  ? 3   ASN A OD1 1 
ATOM 22   N ND2 . ASN A 1 3   ? 145.566 242.469 90.808 1.00 78.46  ? 3   ASN A ND2 1 
ATOM 23   N N   . MET A 1 4   ? 147.647 242.574 86.603 1.00 66.15  ? 4   MET A N   1 
ATOM 24   C CA  . MET A 1 4   ? 146.989 243.058 85.404 1.00 61.26  ? 4   MET A CA  1 
ATOM 25   C C   . MET A 1 4   ? 147.229 242.125 84.233 1.00 65.43  ? 4   MET A C   1 
ATOM 26   O O   . MET A 1 4   ? 146.428 242.125 83.301 1.00 62.84  ? 4   MET A O   1 
ATOM 27   C CB  . MET A 1 4   ? 147.504 244.409 84.928 1.00 56.74  ? 4   MET A CB  1 
ATOM 28   C CG  . MET A 1 4   ? 146.937 245.510 85.707 1.00 60.44  ? 4   MET A CG  1 
ATOM 29   S SD  . MET A 1 4   ? 145.451 246.188 84.962 1.00 61.32  ? 4   MET A SD  1 
ATOM 30   C CE  . MET A 1 4   ? 146.184 247.230 83.700 1.00 58.13  ? 4   MET A CE  1 
ATOM 31   N N   . GLU A 1 5   ? 148.337 241.392 84.235 1.00 66.21  ? 5   GLU A N   1 
ATOM 32   C CA  . GLU A 1 5   ? 148.557 240.420 83.185 1.00 67.72  ? 5   GLU A CA  1 
ATOM 33   C C   . GLU A 1 5   ? 147.571 239.266 83.347 1.00 67.78  ? 5   GLU A C   1 
ATOM 34   O O   . GLU A 1 5   ? 147.010 238.805 82.362 1.00 65.77  ? 5   GLU A O   1 
ATOM 35   C CB  . GLU A 1 5   ? 149.995 239.929 83.158 1.00 70.81  ? 5   GLU A CB  1 
ATOM 36   C CG  . GLU A 1 5   ? 150.929 241.001 82.616 1.00 72.26  ? 5   GLU A CG  1 
ATOM 37   C CD  . GLU A 1 5   ? 152.387 240.569 82.655 1.00 82.05  ? 5   GLU A CD  1 
ATOM 38   O OE1 . GLU A 1 5   ? 152.826 239.991 83.701 1.00 79.14  ? 5   GLU A OE1 1 
ATOM 39   O OE2 . GLU A 1 5   ? 153.076 240.818 81.624 1.00 81.46  ? 5   GLU A OE2 1 
ATOM 40   N N   . LYS A 1 6   ? 147.356 238.815 84.578 1.00 68.44  ? 6   LYS A N   1 
ATOM 41   C CA  . LYS A 1 6   ? 146.344 237.814 84.856 1.00 70.36  ? 6   LYS A CA  1 
ATOM 42   C C   . LYS A 1 6   ? 144.973 238.289 84.368 1.00 62.48  ? 6   LYS A C   1 
ATOM 43   O O   . LYS A 1 6   ? 144.276 237.519 83.726 1.00 62.83  ? 6   LYS A O   1 
ATOM 44   C CB  . LYS A 1 6   ? 146.393 237.468 86.349 1.00 72.82  ? 6   LYS A CB  1 
ATOM 45   C CG  . LYS A 1 6   ? 145.222 236.681 86.902 1.00 77.28  ? 6   LYS A CG  1 
ATOM 46   C CD  . LYS A 1 6   ? 145.046 236.817 88.416 1.00 85.86  ? 6   LYS A CD  1 
ATOM 47   C CE  . LYS A 1 6   ? 143.812 236.100 88.931 1.00 89.70  ? 6   LYS A CE  1 
ATOM 48   N NZ  . LYS A 1 6   ? 143.660 236.150 90.396 1.00 92.80  ? 6   LYS A NZ  1 
ATOM 49   N N   . HIS A 1 7   ? 144.570 239.523 84.663 1.00 63.67  ? 7   HIS A N   1 
ATOM 50   C CA  . HIS A 1 7   ? 143.284 240.028 84.207 1.00 59.30  ? 7   HIS A CA  1 
ATOM 51   C C   . HIS A 1 7   ? 143.213 240.083 82.688 1.00 57.48  ? 7   HIS A C   1 
ATOM 52   O O   . HIS A 1 7   ? 142.182 239.763 82.129 1.00 57.14  ? 7   HIS A O   1 
ATOM 53   C CB  . HIS A 1 7   ? 142.985 241.417 84.775 1.00 58.25  ? 7   HIS A CB  1 
ATOM 54   C CG  . HIS A 1 7   ? 142.799 241.410 86.242 1.00 61.30  ? 7   HIS A CG  1 
ATOM 55   N ND1 . HIS A 1 7   ? 142.158 240.407 86.932 1.00 61.50  ? 7   HIS A ND1 1 
ATOM 56   C CD2 . HIS A 1 7   ? 143.163 242.306 87.153 1.00 66.38  ? 7   HIS A CD2 1 
ATOM 57   C CE1 . HIS A 1 7   ? 142.131 240.707 88.214 1.00 61.32  ? 7   HIS A CE1 1 
ATOM 58   N NE2 . HIS A 1 7   ? 142.751 241.849 88.374 1.00 68.13  ? 7   HIS A NE2 1 
ATOM 59   N N   . LEU A 1 8   ? 144.279 240.535 82.032 1.00 60.20  ? 8   LEU A N   1 
ATOM 60   C CA  . LEU A 1 8   ? 144.324 240.613 80.583 1.00 59.32  ? 8   LEU A CA  1 
ATOM 61   C C   . LEU A 1 8   ? 144.126 239.218 79.997 1.00 59.47  ? 8   LEU A C   1 
ATOM 62   O O   . LEU A 1 8   ? 143.381 239.034 79.050 1.00 60.34  ? 8   LEU A O   1 
ATOM 63   C CB  . LEU A 1 8   ? 145.674 241.193 80.169 1.00 57.70  ? 8   LEU A CB  1 
ATOM 64   C CG  . LEU A 1 8   ? 145.986 241.236 78.669 1.00 58.62  ? 8   LEU A CG  1 
ATOM 65   C CD1 . LEU A 1 8   ? 145.069 242.154 77.905 1.00 57.62  ? 8   LEU A CD1 1 
ATOM 66   C CD2 . LEU A 1 8   ? 147.425 241.646 78.417 1.00 62.34  ? 8   LEU A CD2 1 
ATOM 67   N N   . PHE A 1 9   ? 144.810 238.230 80.553 1.00 59.28  ? 9   PHE A N   1 
ATOM 68   C CA  . PHE A 1 9   ? 144.683 236.871 80.080 1.00 60.54  ? 9   PHE A CA  1 
ATOM 69   C C   . PHE A 1 9   ? 143.240 236.389 80.157 1.00 60.69  ? 9   PHE A C   1 
ATOM 70   O O   . PHE A 1 9   ? 142.735 235.853 79.181 1.00 63.05  ? 9   PHE A O   1 
ATOM 71   C CB  . PHE A 1 9   ? 145.603 236.015 80.935 1.00 61.95  ? 9   PHE A CB  1 
ATOM 72   C CG  . PHE A 1 9   ? 145.619 234.555 80.542 1.00 65.83  ? 9   PHE A CG  1 
ATOM 73   C CD1 . PHE A 1 9   ? 146.511 234.092 79.582 1.00 68.84  ? 9   PHE A CD1 1 
ATOM 74   C CD2 . PHE A 1 9   ? 144.748 233.652 81.148 1.00 68.60  ? 9   PHE A CD2 1 
ATOM 75   C CE1 . PHE A 1 9   ? 146.559 232.746 79.277 1.00 72.50  ? 9   PHE A CE1 1 
ATOM 76   C CE2 . PHE A 1 9   ? 144.779 232.309 80.811 1.00 70.68  ? 9   PHE A CE2 1 
ATOM 77   C CZ  . PHE A 1 9   ? 145.692 231.859 79.887 1.00 72.74  ? 9   PHE A CZ  1 
ATOM 78   N N   . ASN A 1 10  ? 142.593 236.576 81.309 1.00 60.06  ? 10  ASN A N   1 
ATOM 79   C CA  . ASN A 1 10  ? 141.195 236.239 81.494 1.00 54.86  ? 10  ASN A CA  1 
ATOM 80   C C   . ASN A 1 10  ? 140.269 236.971 80.524 1.00 54.83  ? 10  ASN A C   1 
ATOM 81   O O   . ASN A 1 10  ? 139.257 236.421 80.136 1.00 61.26  ? 10  ASN A O   1 
ATOM 82   C CB  . ASN A 1 10  ? 140.733 236.542 82.905 1.00 51.25  ? 10  ASN A CB  1 
ATOM 83   C CG  . ASN A 1 10  ? 141.391 235.651 83.916 1.00 54.01  ? 10  ASN A CG  1 
ATOM 84   O OD1 . ASN A 1 10  ? 141.946 234.614 83.564 1.00 62.92  ? 10  ASN A OD1 1 
ATOM 85   N ND2 . ASN A 1 10  ? 141.359 236.043 85.179 1.00 62.47  ? 10  ASN A ND2 1 
ATOM 86   N N   . LEU A 1 11  ? 140.543 238.213 80.178 1.00 54.95  ? 11  LEU A N   1 
ATOM 87   C CA  . LEU A 1 11  ? 139.618 238.953 79.346 1.00 55.24  ? 11  LEU A CA  1 
ATOM 88   C C   . LEU A 1 11  ? 139.779 238.507 77.901 1.00 60.42  ? 11  LEU A C   1 
ATOM 89   O O   . LEU A 1 11  ? 138.808 238.478 77.163 1.00 61.11  ? 11  LEU A O   1 
ATOM 90   C CB  . LEU A 1 11  ? 139.882 240.444 79.451 1.00 54.70  ? 11  LEU A CB  1 
ATOM 91   C CG  . LEU A 1 11  ? 139.358 241.134 80.699 1.00 51.67  ? 11  LEU A CG  1 
ATOM 92   C CD1 . LEU A 1 11  ? 140.221 242.342 80.987 1.00 53.74  ? 11  LEU A CD1 1 
ATOM 93   C CD2 . LEU A 1 11  ? 137.908 241.545 80.443 1.00 54.70  ? 11  LEU A CD2 1 
ATOM 94   N N   . LYS A 1 12  ? 141.017 238.251 77.481 1.00 60.67  ? 12  LYS A N   1 
ATOM 95   C CA  . LYS A 1 12  ? 141.268 237.756 76.145 1.00 63.02  ? 12  LYS A CA  1 
ATOM 96   C C   . LYS A 1 12  ? 140.588 236.400 75.955 1.00 64.54  ? 12  LYS A C   1 
ATOM 97   O O   . LYS A 1 12  ? 140.121 236.098 74.860 1.00 64.83  ? 12  LYS A O   1 
ATOM 98   C CB  . LYS A 1 12  ? 142.764 237.611 75.868 1.00 63.91  ? 12  LYS A CB  1 
ATOM 99   C CG  . LYS A 1 12  ? 143.467 238.842 75.348 1.00 64.15  ? 12  LYS A CG  1 
ATOM 100  C CD  . LYS A 1 12  ? 144.899 238.465 74.977 1.00 70.69  ? 12  LYS A CD  1 
ATOM 101  C CE  . LYS A 1 12  ? 145.863 239.622 74.834 1.00 77.90  ? 12  LYS A CE  1 
ATOM 102  N NZ  . LYS A 1 12  ? 145.374 240.732 73.987 1.00 80.40  ? 12  LYS A NZ  1 
ATOM 103  N N   . PHE A 1 13  ? 140.579 235.581 77.008 1.00 64.15  ? 13  PHE A N   1 
ATOM 104  C CA  . PHE A 1 13  ? 139.957 234.272 76.961 1.00 64.77  ? 13  PHE A CA  1 
ATOM 105  C C   . PHE A 1 13  ? 138.438 234.400 76.927 1.00 63.45  ? 13  PHE A C   1 
ATOM 106  O O   . PHE A 1 13  ? 137.803 233.780 76.109 1.00 69.04  ? 13  PHE A O   1 
ATOM 107  C CB  . PHE A 1 13  ? 140.422 233.479 78.168 1.00 65.87  ? 13  PHE A CB  1 
ATOM 108  C CG  . PHE A 1 13  ? 139.821 232.095 78.292 1.00 71.49  ? 13  PHE A CG  1 
ATOM 109  C CD1 . PHE A 1 13  ? 140.455 230.986 77.734 1.00 75.88  ? 13  PHE A CD1 1 
ATOM 110  C CD2 . PHE A 1 13  ? 138.651 231.898 79.007 1.00 73.74  ? 13  PHE A CD2 1 
ATOM 111  C CE1 . PHE A 1 13  ? 139.931 229.718 77.899 1.00 75.15  ? 13  PHE A CE1 1 
ATOM 112  C CE2 . PHE A 1 13  ? 138.134 230.619 79.173 1.00 79.26  ? 13  PHE A CE2 1 
ATOM 113  C CZ  . PHE A 1 13  ? 138.776 229.537 78.620 1.00 78.77  ? 13  PHE A CZ  1 
ATOM 114  N N   . ALA A 1 14  ? 137.834 235.221 77.774 1.00 65.39  ? 14  ALA A N   1 
ATOM 115  C CA  . ALA A 1 14  ? 136.397 235.458 77.713 1.00 62.26  ? 14  ALA A CA  1 
ATOM 116  C C   . ALA A 1 14  ? 135.959 235.915 76.327 1.00 65.15  ? 14  ALA A C   1 
ATOM 117  O O   . ALA A 1 14  ? 134.843 235.618 75.924 1.00 66.90  ? 14  ALA A O   1 
ATOM 118  C CB  . ALA A 1 14  ? 135.989 236.512 78.707 1.00 60.71  ? 14  ALA A CB  1 
ATOM 119  N N   . ALA A 1 15  ? 136.782 236.698 75.635 1.00 61.35  ? 15  ALA A N   1 
ATOM 120  C CA  . ALA A 1 15  ? 136.390 237.166 74.328 1.00 62.72  ? 15  ALA A CA  1 
ATOM 121  C C   . ALA A 1 15  ? 136.388 235.986 73.354 1.00 67.51  ? 15  ALA A C   1 
ATOM 122  O O   . ALA A 1 15  ? 135.518 235.923 72.485 1.00 66.66  ? 15  ALA A O   1 
ATOM 123  C CB  . ALA A 1 15  ? 137.278 238.303 73.858 1.00 63.78  ? 15  ALA A CB  1 
ATOM 124  N N   . LYS A 1 16  ? 137.329 235.050 73.495 1.00 64.90  ? 16  LYS A N   1 
ATOM 125  C CA  . LYS A 1 16  ? 137.382 233.908 72.597 1.00 70.73  ? 16  LYS A CA  1 
ATOM 126  C C   . LYS A 1 16  ? 136.236 232.937 72.888 1.00 71.66  ? 16  LYS A C   1 
ATOM 127  O O   . LYS A 1 16  ? 135.628 232.398 71.968 1.00 70.81  ? 16  LYS A O   1 
ATOM 128  C CB  . LYS A 1 16  ? 138.714 233.152 72.646 1.00 72.17  ? 16  LYS A CB  1 
ATOM 129  C CG  . LYS A 1 16  ? 139.723 233.753 71.681 1.00 77.43  ? 16  LYS A CG  1 
ATOM 130  C CD  . LYS A 1 16  ? 140.995 232.919 71.584 1.00 85.48  ? 16  LYS A CD  1 
ATOM 131  C CE  . LYS A 1 16  ? 142.069 233.548 70.724 1.00 89.94  ? 16  LYS A CE  1 
ATOM 132  N NZ  . LYS A 1 16  ? 141.683 233.726 69.315 1.00 91.90  ? 16  LYS A NZ  1 
ATOM 133  N N   . GLU A 1 17  ? 135.940 232.741 74.164 1.00 69.96  ? 17  GLU A N   1 
ATOM 134  C CA  . GLU A 1 17  ? 134.861 231.880 74.586 1.00 71.71  ? 17  GLU A CA  1 
ATOM 135  C C   . GLU A 1 17  ? 133.550 232.378 73.986 1.00 68.31  ? 17  GLU A C   1 
ATOM 136  O O   . GLU A 1 17  ? 132.724 231.579 73.579 1.00 72.32  ? 17  GLU A O   1 
ATOM 137  C CB  . GLU A 1 17  ? 134.838 231.908 76.111 1.00 72.76  ? 17  GLU A CB  1 
ATOM 138  C CG  . GLU A 1 17  ? 134.124 230.744 76.782 1.00 77.90  ? 17  GLU A CG  1 
ATOM 139  C CD  . GLU A 1 17  ? 135.015 229.507 76.934 1.00 90.61  ? 17  GLU A CD  1 
ATOM 140  O OE1 . GLU A 1 17  ? 135.732 229.161 75.947 1.00 88.83  ? 17  GLU A OE1 1 
ATOM 141  O OE2 . GLU A 1 17  ? 134.981 228.868 78.028 1.00 85.38  ? 17  GLU A OE2 1 
ATOM 142  N N   . LEU A 1 18  ? 133.337 233.683 73.952 1.00 67.15  ? 18  LEU A N   1 
ATOM 143  C CA  . LEU A 1 18  ? 132.125 234.254 73.404 1.00 65.71  ? 18  LEU A CA  1 
ATOM 144  C C   . LEU A 1 18  ? 132.115 234.073 71.893 1.00 67.28  ? 18  LEU A C   1 
ATOM 145  O O   . LEU A 1 18  ? 131.058 233.907 71.307 1.00 66.69  ? 18  LEU A O   1 
ATOM 146  C CB  . LEU A 1 18  ? 132.024 235.734 73.776 1.00 63.03  ? 18  LEU A CB  1 
ATOM 147  C CG  . LEU A 1 18  ? 131.638 236.021 75.230 1.00 65.12  ? 18  LEU A CG  1 
ATOM 148  C CD1 . LEU A 1 18  ? 132.032 237.431 75.596 1.00 61.92  ? 18  LEU A CD1 1 
ATOM 149  C CD2 . LEU A 1 18  ? 130.145 235.828 75.492 1.00 64.19  ? 18  LEU A CD2 1 
ATOM 150  N N   . SER A 1 19  ? 133.281 234.146 71.263 1.00 68.06  ? 19  SER A N   1 
ATOM 151  C CA  . SER A 1 19  ? 133.367 234.051 69.820 1.00 68.82  ? 19  SER A CA  1 
ATOM 152  C C   . SER A 1 19  ? 133.033 232.618 69.370 1.00 70.16  ? 19  SER A C   1 
ATOM 153  O O   . SER A 1 19  ? 132.388 232.404 68.344 1.00 68.70  ? 19  SER A O   1 
ATOM 154  C CB  . SER A 1 19  ? 134.740 234.482 69.366 1.00 68.23  ? 19  SER A CB  1 
ATOM 155  O OG  . SER A 1 19  ? 134.707 234.964 68.027 1.00 74.01  ? 19  SER A OG  1 
ATOM 156  N N   . ARG A 1 20  ? 133.494 231.644 70.156 1.00 68.83  ? 20  ARG A N   1 
ATOM 157  C CA  . ARG A 1 20  ? 133.173 230.248 69.956 1.00 70.59  ? 20  ARG A CA  1 
ATOM 158  C C   . ARG A 1 20  ? 131.678 230.004 70.151 1.00 69.83  ? 20  ARG A C   1 
ATOM 159  O O   . ARG A 1 20  ? 131.067 229.283 69.374 1.00 69.85  ? 20  ARG A O   1 
ATOM 160  C CB  . ARG A 1 20  ? 134.000 229.355 70.886 1.00 72.49  ? 20  ARG A CB  1 
ATOM 161  C CG  . ARG A 1 20  ? 135.421 229.206 70.354 1.00 78.04  ? 20  ARG A CG  1 
ATOM 162  C CD  . ARG A 1 20  ? 136.171 228.112 71.085 1.00 86.61  ? 20  ARG A CD  1 
ATOM 163  N NE  . ARG A 1 20  ? 136.419 228.444 72.495 1.00 89.35  ? 20  ARG A NE  1 
ATOM 164  C CZ  . ARG A 1 20  ? 137.581 228.894 72.967 1.00 89.66  ? 20  ARG A CZ  1 
ATOM 165  N NH1 . ARG A 1 20  ? 137.678 229.179 74.262 1.00 87.89  ? 20  ARG A NH1 1 
ATOM 166  N NH2 . ARG A 1 20  ? 138.619 229.083 72.149 1.00 86.07  ? 20  ARG A NH2 1 
ATOM 167  N N   . SER A 1 21  ? 131.079 230.604 71.169 1.00 68.02  ? 21  SER A N   1 
ATOM 168  C CA  . SER A 1 21  ? 129.647 230.481 71.358 1.00 66.77  ? 21  SER A CA  1 
ATOM 169  C C   . SER A 1 21  ? 128.863 231.007 70.153 1.00 66.51  ? 21  SER A C   1 
ATOM 170  O O   . SER A 1 21  ? 127.774 230.528 69.873 1.00 68.57  ? 21  SER A O   1 
ATOM 171  C CB  . SER A 1 21  ? 129.230 231.171 72.617 1.00 67.28  ? 21  SER A CB  1 
ATOM 172  O OG  . SER A 1 21  ? 129.839 230.513 73.719 1.00 70.06  ? 21  SER A OG  1 
ATOM 173  N N   . ALA A 1 22  ? 129.372 232.013 69.461 1.00 64.95  ? 22  ALA A N   1 
ATOM 174  C CA  . ALA A 1 22  ? 128.640 232.557 68.341 1.00 63.50  ? 22  ALA A CA  1 
ATOM 175  C C   . ALA A 1 22  ? 128.779 231.615 67.152 1.00 69.56  ? 22  ALA A C   1 
ATOM 176  O O   . ALA A 1 22  ? 127.880 231.536 66.323 1.00 69.94  ? 22  ALA A O   1 
ATOM 177  C CB  . ALA A 1 22  ? 129.123 233.951 68.021 1.00 63.56  ? 22  ALA A CB  1 
ATOM 178  N N   . LYS A 1 23  ? 129.911 230.909 67.060 1.00 70.36  ? 23  LYS A N   1 
ATOM 179  C CA  . LYS A 1 23  ? 130.124 229.955 65.989 1.00 69.87  ? 23  LYS A CA  1 
ATOM 180  C C   . LYS A 1 23  ? 129.229 228.741 66.206 1.00 71.67  ? 23  LYS A C   1 
ATOM 181  O O   . LYS A 1 23  ? 128.621 228.240 65.261 1.00 74.43  ? 23  LYS A O   1 
ATOM 182  C CB  . LYS A 1 23  ? 131.587 229.527 65.862 1.00 70.33  ? 23  LYS A CB  1 
ATOM 183  C CG  . LYS A 1 23  ? 132.361 230.458 64.957 1.00 74.30  ? 23  LYS A CG  1 
ATOM 184  C CD  . LYS A 1 23  ? 133.849 230.136 64.874 1.00 82.93  ? 23  LYS A CD  1 
ATOM 185  C CE  . LYS A 1 23  ? 134.694 231.290 64.343 1.00 86.36  ? 23  LYS A CE  1 
ATOM 186  N NZ  . LYS A 1 23  ? 134.869 232.411 65.282 1.00 82.28  ? 23  LYS A NZ  1 
ATOM 187  N N   . LYS A 1 24  ? 129.125 228.288 67.444 1.00 68.97  ? 24  LYS A N   1 
ATOM 188  C CA  . LYS A 1 24  ? 128.280 227.153 67.735 1.00 69.34  ? 24  LYS A CA  1 
ATOM 189  C C   . LYS A 1 24  ? 126.826 227.495 67.430 1.00 69.38  ? 24  LYS A C   1 
ATOM 190  O O   . LYS A 1 24  ? 126.082 226.653 66.959 1.00 75.41  ? 24  LYS A O   1 
ATOM 191  C CB  . LYS A 1 24  ? 128.503 226.713 69.180 1.00 70.43  ? 24  LYS A CB  1 
ATOM 192  C CG  . LYS A 1 24  ? 127.841 225.416 69.495 1.00 77.39  ? 24  LYS A CG  1 
ATOM 193  C CD  . LYS A 1 24  ? 128.372 224.781 70.771 1.00 85.39  ? 24  LYS A CD  1 
ATOM 194  C CE  . LYS A 1 24  ? 127.784 223.398 70.975 1.00 89.86  ? 24  LYS A CE  1 
ATOM 195  N NZ  . LYS A 1 24  ? 126.332 223.428 71.234 1.00 88.90  ? 24  LYS A NZ  1 
ATOM 196  N N   . CYS A 1 25  ? 126.405 228.715 67.705 1.00 68.52  ? 25  CYS A N   1 
ATOM 197  C CA  . CYS A 1 25  ? 125.040 229.114 67.443 1.00 68.43  ? 25  CYS A CA  1 
ATOM 198  C C   . CYS A 1 25  ? 124.765 229.182 65.951 1.00 71.77  ? 25  CYS A C   1 
ATOM 199  O O   . CYS A 1 25  ? 123.642 228.930 65.541 1.00 71.89  ? 25  CYS A O   1 
ATOM 200  C CB  . CYS A 1 25  ? 124.732 230.470 68.072 1.00 67.78  ? 25  CYS A CB  1 
ATOM 201  S SG  . CYS A 1 25  ? 124.338 230.346 69.836 1.00 67.61  ? 25  CYS A SG  1 
ATOM 202  N N   . ASP A 1 26  ? 125.764 229.567 65.158 1.00 72.48  ? 26  ASP A N   1 
ATOM 203  C CA  . ASP A 1 26  ? 125.644 229.673 63.713 1.00 75.15  ? 26  ASP A CA  1 
ATOM 204  C C   . ASP A 1 26  ? 125.542 228.275 63.076 1.00 78.01  ? 26  ASP A C   1 
ATOM 205  O O   . ASP A 1 26  ? 124.785 228.053 62.126 1.00 77.37  ? 26  ASP A O   1 
ATOM 206  C CB  . ASP A 1 26  ? 126.806 230.501 63.190 1.00 78.03  ? 26  ASP A CB  1 
ATOM 207  C CG  . ASP A 1 26  ? 126.916 230.583 61.666 1.00 88.94  ? 26  ASP A CG  1 
ATOM 208  O OD1 . ASP A 1 26  ? 127.518 229.637 61.054 1.00 88.84  ? 26  ASP A OD1 1 
ATOM 209  O OD2 . ASP A 1 26  ? 126.376 231.570 61.080 1.00 87.73  ? 26  ASP A OD2 1 
ATOM 210  N N   . LYS A 1 27  ? 126.335 227.340 63.597 1.00 76.10  ? 27  LYS A N   1 
ATOM 211  C CA  . LYS A 1 27  ? 126.320 225.946 63.188 1.00 75.11  ? 27  LYS A CA  1 
ATOM 212  C C   . LYS A 1 27  ? 124.971 225.309 63.487 1.00 75.76  ? 27  LYS A C   1 
ATOM 213  O O   . LYS A 1 27  ? 124.465 224.519 62.693 1.00 77.01  ? 27  LYS A O   1 
ATOM 214  C CB  . LYS A 1 27  ? 127.433 225.212 63.942 1.00 79.06  ? 27  LYS A CB  1 
ATOM 215  C CG  . LYS A 1 27  ? 127.633 223.765 63.600 1.00 81.37  ? 27  LYS A CG  1 
ATOM 216  C CD  . LYS A 1 27  ? 128.703 223.110 64.462 1.00 86.36  ? 27  LYS A CD  1 
ATOM 217  C CE  . LYS A 1 27  ? 128.875 221.639 64.192 1.00 93.38  ? 27  LYS A CE  1 
ATOM 218  N NZ  . LYS A 1 27  ? 129.538 221.395 62.897 1.00 98.53  ? 27  LYS A NZ  1 
ATOM 219  N N   . GLU A 1 28  ? 124.377 225.630 64.632 1.00 76.24  ? 28  GLU A N   1 
ATOM 220  C CA  . GLU A 1 28  ? 123.094 225.051 65.023 1.00 74.27  ? 28  GLU A CA  1 
ATOM 221  C C   . GLU A 1 28  ? 121.909 225.740 64.356 1.00 69.05  ? 28  GLU A C   1 
ATOM 222  O O   . GLU A 1 28  ? 120.880 225.113 64.217 1.00 70.40  ? 28  GLU A O   1 
ATOM 223  C CB  . GLU A 1 28  ? 122.961 225.005 66.544 1.00 73.14  ? 28  GLU A CB  1 
ATOM 224  C CG  . GLU A 1 28  ? 123.885 223.915 67.062 1.00 78.10  ? 28  GLU A CG  1 
ATOM 225  C CD  . GLU A 1 28  ? 123.928 223.735 68.560 1.00 86.62  ? 28  GLU A CD  1 
ATOM 226  O OE1 . GLU A 1 28  ? 123.097 224.377 69.248 1.00 85.03  ? 28  GLU A OE1 1 
ATOM 227  O OE2 . GLU A 1 28  ? 124.814 222.964 69.036 1.00 89.20  ? 28  GLU A OE2 1 
ATOM 228  N N   . GLU A 1 29  ? 122.029 226.984 63.919 1.00 70.62  ? 29  GLU A N   1 
ATOM 229  C CA  . GLU A 1 29  ? 121.013 227.553 63.054 1.00 71.04  ? 29  GLU A CA  1 
ATOM 230  C C   . GLU A 1 29  ? 120.909 226.713 61.773 1.00 71.49  ? 29  GLU A C   1 
ATOM 231  O O   . GLU A 1 29  ? 119.804 226.407 61.331 1.00 70.73  ? 29  GLU A O   1 
ATOM 232  C CB  . GLU A 1 29  ? 121.278 229.038 62.787 1.00 70.74  ? 29  GLU A CB  1 
ATOM 233  C CG  . GLU A 1 29  ? 120.147 229.704 62.010 1.00 69.77  ? 29  GLU A CG  1 
ATOM 234  C CD  . GLU A 1 29  ? 120.475 231.045 61.365 1.00 78.13  ? 29  GLU A CD  1 
ATOM 235  O OE1 . GLU A 1 29  ? 121.593 231.603 61.574 1.00 77.96  ? 29  GLU A OE1 1 
ATOM 236  O OE2 . GLU A 1 29  ? 119.589 231.551 60.615 1.00 77.80  ? 29  GLU A OE2 1 
ATOM 237  N N   . LYS A 1 30  ? 122.052 226.351 61.170 1.00 73.72  ? 30  LYS A N   1 
ATOM 238  C CA  . LYS A 1 30  ? 122.095 225.573 59.938 1.00 73.62  ? 30  LYS A CA  1 
ATOM 239  C C   . LYS A 1 30  ? 121.503 224.182 60.169 1.00 74.56  ? 30  LYS A C   1 
ATOM 240  O O   . LYS A 1 30  ? 120.720 223.694 59.345 1.00 72.52  ? 30  LYS A O   1 
ATOM 241  C CB  . LYS A 1 30  ? 123.522 225.473 59.384 1.00 74.60  ? 30  LYS A CB  1 
ATOM 242  C CG  . LYS A 1 30  ? 124.023 226.777 58.774 1.00 83.26  ? 30  LYS A CG  1 
ATOM 243  C CD  . LYS A 1 30  ? 125.510 226.740 58.411 1.00 89.53  ? 30  LYS A CD  1 
ATOM 244  C CE  . LYS A 1 30  ? 126.036 228.038 57.802 1.00 94.58  ? 30  LYS A CE  1 
ATOM 245  N NZ  . LYS A 1 30  ? 126.078 229.197 58.724 1.00 91.61  ? 30  LYS A NZ  1 
ATOM 246  N N   . ALA A 1 31  ? 121.882 223.540 61.276 1.00 70.81  ? 31  ALA A N   1 
ATOM 247  C CA  . ALA A 1 31  ? 121.379 222.214 61.607 1.00 68.14  ? 31  ALA A CA  1 
ATOM 248  C C   . ALA A 1 31  ? 119.872 222.216 61.870 1.00 68.67  ? 31  ALA A C   1 
ATOM 249  O O   . ALA A 1 31  ? 119.193 221.287 61.459 1.00 72.71  ? 31  ALA A O   1 
ATOM 250  C CB  . ALA A 1 31  ? 122.133 221.662 62.787 1.00 71.83  ? 31  ALA A CB  1 
ATOM 251  N N   . GLU A 1 32  ? 119.328 223.225 62.543 1.00 69.56  ? 32  GLU A N   1 
ATOM 252  C CA  . GLU A 1 32  ? 117.901 223.293 62.804 1.00 67.51  ? 32  GLU A CA  1 
ATOM 253  C C   . GLU A 1 32  ? 117.136 223.611 61.525 1.00 67.89  ? 32  GLU A C   1 
ATOM 254  O O   . GLU A 1 32  ? 116.017 223.131 61.380 1.00 70.13  ? 32  GLU A O   1 
ATOM 255  C CB  . GLU A 1 32  ? 117.559 224.277 63.934 1.00 67.17  ? 32  GLU A CB  1 
ATOM 256  C CG  . GLU A 1 32  ? 118.054 223.808 65.302 1.00 68.40  ? 32  GLU A CG  1 
ATOM 257  C CD  . GLU A 1 32  ? 117.399 222.533 65.850 1.00 73.44  ? 32  GLU A CD  1 
ATOM 258  O OE1 . GLU A 1 32  ? 116.172 222.552 66.173 1.00 67.71  ? 32  GLU A OE1 1 
ATOM 259  O OE2 . GLU A 1 32  ? 118.120 221.498 65.951 1.00 74.55  ? 32  GLU A OE2 1 
ATOM 260  N N   . LYS A 1 33  ? 117.678 224.436 60.623 1.00 70.96  ? 33  LYS A N   1 
ATOM 261  C CA  . LYS A 1 33  ? 117.025 224.733 59.350 1.00 70.75  ? 33  LYS A CA  1 
ATOM 262  C C   . LYS A 1 33  ? 116.849 223.449 58.538 1.00 70.02  ? 33  LYS A C   1 
ATOM 263  O O   . LYS A 1 33  ? 115.824 223.265 57.890 1.00 71.94  ? 33  LYS A O   1 
ATOM 264  C CB  . LYS A 1 33  ? 117.803 225.807 58.578 1.00 72.20  ? 33  LYS A CB  1 
ATOM 265  C CG  . LYS A 1 33  ? 117.356 227.238 58.872 1.00 72.05  ? 33  LYS A CG  1 
ATOM 266  C CD  . LYS A 1 33  ? 118.277 228.265 58.205 1.00 78.21  ? 33  LYS A CD  1 
ATOM 267  C CE  . LYS A 1 33  ? 117.700 229.633 57.993 1.00 81.50  ? 33  LYS A CE  1 
ATOM 268  N NZ  . LYS A 1 33  ? 117.484 230.376 59.242 1.00 82.05  ? 33  LYS A NZ  1 
ATOM 269  N N   . ALA A 1 34  ? 117.852 222.569 58.565 1.00 70.04  ? 34  ALA A N   1 
ATOM 270  C CA  . ALA A 1 34  ? 117.788 221.301 57.858 1.00 69.68  ? 34  ALA A CA  1 
ATOM 271  C C   . ALA A 1 34  ? 116.626 220.441 58.372 1.00 71.32  ? 34  ALA A C   1 
ATOM 272  O O   . ALA A 1 34  ? 115.958 219.769 57.588 1.00 76.45  ? 34  ALA A O   1 
ATOM 273  C CB  . ALA A 1 34  ? 119.128 220.583 57.983 1.00 71.89  ? 34  ALA A CB  1 
ATOM 274  N N   . LYS A 1 35  ? 116.370 220.468 59.683 1.00 69.70  ? 35  LYS A N   1 
ATOM 275  C CA  . LYS A 1 35  ? 115.277 219.733 60.304 1.00 64.60  ? 35  LYS A CA  1 
ATOM 276  C C   . LYS A 1 35  ? 113.901 220.328 59.989 1.00 67.91  ? 35  LYS A C   1 
ATOM 277  O O   . LYS A 1 35  ? 112.929 219.591 59.992 1.00 73.26  ? 35  LYS A O   1 
ATOM 278  C CB  . LYS A 1 35  ? 115.492 219.664 61.815 1.00 63.21  ? 35  LYS A CB  1 
ATOM 279  C CG  . LYS A 1 35  ? 116.717 218.880 62.207 1.00 68.76  ? 35  LYS A CG  1 
ATOM 280  C CD  . LYS A 1 35  ? 117.016 218.954 63.691 1.00 68.74  ? 35  LYS A CD  1 
ATOM 281  C CE  . LYS A 1 35  ? 118.424 218.525 63.994 1.00 74.37  ? 35  LYS A CE  1 
ATOM 282  N NZ  . LYS A 1 35  ? 118.801 218.837 65.385 1.00 77.38  ? 35  LYS A NZ  1 
ATOM 283  N N   . ILE A 1 36  ? 113.777 221.629 59.741 1.00 68.50  ? 36  ILE A N   1 
ATOM 284  C CA  . ILE A 1 36  ? 112.495 222.188 59.335 1.00 71.11  ? 36  ILE A CA  1 
ATOM 285  C C   . ILE A 1 36  ? 112.098 221.566 57.993 1.00 74.55  ? 36  ILE A C   1 
ATOM 286  O O   . ILE A 1 36  ? 110.949 221.178 57.831 1.00 77.14  ? 36  ILE A O   1 
ATOM 287  C CB  . ILE A 1 36  ? 112.498 223.732 59.256 1.00 72.59  ? 36  ILE A CB  1 
ATOM 288  C CG1 . ILE A 1 36  ? 112.937 224.425 60.559 1.00 67.83  ? 36  ILE A CG1 1 
ATOM 289  C CG2 . ILE A 1 36  ? 111.127 224.247 58.820 1.00 69.41  ? 36  ILE A CG2 1 
ATOM 290  C CD1 . ILE A 1 36  ? 113.337 225.882 60.356 1.00 70.06  ? 36  ILE A CD1 1 
ATOM 291  N N   . LYS A 1 37  ? 113.027 221.470 57.031 1.00 75.54  ? 37  LYS A N   1 
ATOM 292  C CA  . LYS A 1 37  ? 112.730 220.925 55.710 1.00 81.94  ? 37  LYS A CA  1 
ATOM 293  C C   . LYS A 1 37  ? 112.200 219.490 55.821 1.00 81.21  ? 37  LYS A C   1 
ATOM 294  O O   . LYS A 1 37  ? 111.157 219.174 55.245 1.00 82.21  ? 37  LYS A O   1 
ATOM 295  C CB  . LYS A 1 37  ? 113.967 221.002 54.801 1.00 86.77  ? 37  LYS A CB  1 
ATOM 296  C CG  . LYS A 1 37  ? 114.301 222.424 54.385 1.00 92.25  ? 37  LYS A CG  1 
ATOM 297  C CD  . LYS A 1 37  ? 115.431 222.530 53.368 1.00 99.86  ? 37  LYS A CD  1 
ATOM 298  C CE  . LYS A 1 37  ? 115.706 223.964 52.970 1.00 102.67 ? 37  LYS A CE  1 
ATOM 299  N NZ  . LYS A 1 37  ? 116.684 224.046 51.875 1.00 105.17 ? 37  LYS A NZ  1 
ATOM 300  N N   . LYS A 1 38  ? 112.918 218.638 56.568 1.00 77.04  ? 38  LYS A N   1 
ATOM 301  C CA  . LYS A 1 38  ? 112.538 217.250 56.766 1.00 75.70  ? 38  LYS A CA  1 
ATOM 302  C C   . LYS A 1 38  ? 111.159 217.139 57.411 1.00 75.93  ? 38  LYS A C   1 
ATOM 303  O O   . LYS A 1 38  ? 110.382 216.279 57.027 1.00 83.96  ? 38  LYS A O   1 
ATOM 304  C CB  . LYS A 1 38  ? 113.626 216.522 57.554 1.00 76.43  ? 38  LYS A CB  1 
ATOM 305  C CG  . LYS A 1 38  ? 114.933 216.424 56.795 1.00 83.23  ? 38  LYS A CG  1 
ATOM 306  C CD  . LYS A 1 38  ? 116.095 215.873 57.618 1.00 89.67  ? 38  LYS A CD  1 
ATOM 307  C CE  . LYS A 1 38  ? 116.100 214.372 57.789 1.00 94.06  ? 38  LYS A CE  1 
ATOM 308  N NZ  . LYS A 1 38  ? 116.642 213.677 56.609 1.00 97.65  ? 38  LYS A NZ  1 
ATOM 309  N N   . ALA A 1 39  ? 110.845 217.993 58.377 1.00 76.86  ? 39  ALA A N   1 
ATOM 310  C CA  . ALA A 1 39  ? 109.554 217.989 59.050 1.00 77.65  ? 39  ALA A CA  1 
ATOM 311  C C   . ALA A 1 39  ? 108.425 218.470 58.132 1.00 79.16  ? 39  ALA A C   1 
ATOM 312  O O   . ALA A 1 39  ? 107.343 217.908 58.201 1.00 82.42  ? 39  ALA A O   1 
ATOM 313  C CB  . ALA A 1 39  ? 109.643 218.829 60.321 1.00 76.00  ? 39  ALA A CB  1 
ATOM 314  N N   . ILE A 1 40  ? 108.647 219.511 57.317 1.00 80.45  ? 40  ILE A N   1 
ATOM 315  C CA  . ILE A 1 40  ? 107.661 219.997 56.349 1.00 83.27  ? 40  ILE A CA  1 
ATOM 316  C C   . ILE A 1 40  ? 107.324 218.893 55.333 1.00 84.13  ? 40  ILE A C   1 
ATOM 317  O O   . ILE A 1 40  ? 106.151 218.684 55.031 1.00 84.61  ? 40  ILE A O   1 
ATOM 318  C CB  . ILE A 1 40  ? 108.161 221.278 55.640 1.00 83.91  ? 40  ILE A CB  1 
ATOM 319  C CG1 . ILE A 1 40  ? 108.256 222.494 56.568 1.00 81.16  ? 40  ILE A CG1 1 
ATOM 320  C CG2 . ILE A 1 40  ? 107.328 221.608 54.396 1.00 86.54  ? 40  ILE A CG2 1 
ATOM 321  C CD1 . ILE A 1 40  ? 106.930 223.101 56.982 1.00 84.31  ? 40  ILE A CD1 1 
ATOM 322  N N   . GLN A 1 41  ? 108.333 218.175 54.819 1.00 84.13  ? 41  GLN A N   1 
ATOM 323  C CA  . GLN A 1 41  ? 108.120 217.080 53.870 1.00 87.67  ? 41  GLN A CA  1 
ATOM 324  C C   . GLN A 1 41  ? 107.210 215.987 54.451 1.00 87.44  ? 41  GLN A C   1 
ATOM 325  O O   . GLN A 1 41  ? 106.290 215.533 53.763 1.00 87.97  ? 41  GLN A O   1 
ATOM 326  C CB  . GLN A 1 41  ? 109.463 216.504 53.406 1.00 89.46  ? 41  GLN A CB  1 
ATOM 327  C CG  . GLN A 1 41  ? 110.187 217.426 52.426 1.00 92.23  ? 41  GLN A CG  1 
ATOM 328  C CD  . GLN A 1 41  ? 111.626 217.020 52.147 1.00 96.68  ? 41  GLN A CD  1 
ATOM 329  O OE1 . GLN A 1 41  ? 112.193 216.126 52.797 1.00 91.94  ? 41  GLN A OE1 1 
ATOM 330  N NE2 . GLN A 1 41  ? 112.242 217.698 51.180 1.00 101.69 ? 41  GLN A NE2 1 
ATOM 331  N N   . LYS A 1 42  ? 107.442 215.593 55.712 1.00 84.38  ? 42  LYS A N   1 
ATOM 332  C CA  . LYS A 1 42  ? 106.617 214.620 56.423 1.00 84.51  ? 42  LYS A CA  1 
ATOM 333  C C   . LYS A 1 42  ? 105.289 215.186 56.940 1.00 83.93  ? 42  LYS A C   1 
ATOM 334  O O   . LYS A 1 42  ? 104.518 214.444 57.549 1.00 86.12  ? 42  LYS A O   1 
ATOM 335  C CB  . LYS A 1 42  ? 107.379 214.074 57.632 1.00 86.14  ? 42  LYS A CB  1 
ATOM 336  C CG  . LYS A 1 42  ? 108.528 213.178 57.232 1.00 89.27  ? 42  LYS A CG  1 
ATOM 337  C CD  . LYS A 1 42  ? 109.349 212.708 58.429 1.00 92.16  ? 42  LYS A CD  1 
ATOM 338  C CE  . LYS A 1 42  ? 110.285 211.581 58.085 1.00 96.56  ? 42  LYS A CE  1 
ATOM 339  N NZ  . LYS A 1 42  ? 111.277 211.932 57.056 1.00 100.45 ? 42  LYS A NZ  1 
ATOM 340  N N   . GLY A 1 43  ? 105.017 216.480 56.734 1.00 83.24  ? 43  GLY A N   1 
ATOM 341  C CA  . GLY A 1 43  ? 103.787 217.102 57.212 1.00 84.81  ? 43  GLY A CA  1 
ATOM 342  C C   . GLY A 1 43  ? 103.672 217.186 58.745 1.00 85.69  ? 43  GLY A C   1 
ATOM 343  O O   . GLY A 1 43  ? 102.565 217.374 59.260 1.00 85.42  ? 43  GLY A O   1 
ATOM 344  N N   . ASN A 1 44  ? 104.812 217.104 59.440 1.00 83.53  ? 44  ASN A N   1 
ATOM 345  C CA  . ASN A 1 44  ? 104.841 217.276 60.919 1.00 82.14  ? 44  ASN A CA  1 
ATOM 346  C C   . ASN A 1 44  ? 104.972 218.779 61.169 1.00 78.91  ? 44  ASN A C   1 
ATOM 347  O O   . ASN A 1 44  ? 106.115 219.241 61.301 1.00 73.79  ? 44  ASN A O   1 
ATOM 348  C CB  . ASN A 1 44  ? 105.961 216.465 61.563 1.00 81.08  ? 44  ASN A CB  1 
ATOM 349  C CG  . ASN A 1 44  ? 105.683 214.982 61.531 1.00 88.16  ? 44  ASN A CG  1 
ATOM 350  O OD1 . ASN A 1 44  ? 104.523 214.568 61.430 1.00 90.47  ? 44  ASN A OD1 1 
ATOM 351  N ND2 . ASN A 1 44  ? 106.726 214.172 61.621 1.00 90.87  ? 44  ASN A ND2 1 
ATOM 352  N N   . MET A 1 45  ? 103.863 219.523 61.131 1.00 80.45  ? 45  MET A N   1 
ATOM 353  C CA  . MET A 1 45  ? 103.925 220.975 61.270 1.00 79.37  ? 45  MET A CA  1 
ATOM 354  C C   . MET A 1 45  ? 104.233 221.439 62.706 1.00 75.98  ? 45  MET A C   1 
ATOM 355  O O   . MET A 1 45  ? 104.753 222.536 62.899 1.00 71.43  ? 45  MET A O   1 
ATOM 356  C CB  . MET A 1 45  ? 102.621 221.614 60.779 1.00 81.65  ? 45  MET A CB  1 
ATOM 357  C CG  . MET A 1 45  ? 102.354 221.334 59.318 1.00 89.28  ? 45  MET A CG  1 
ATOM 358  S SD  . MET A 1 45  ? 103.724 221.801 58.240 1.00 99.07  ? 45  MET A SD  1 
ATOM 359  C CE  . MET A 1 45  ? 103.022 221.164 56.698 1.00 111.88 ? 45  MET A CE  1 
ATOM 360  N N   . GLU A 1 46  ? 103.915 220.633 63.716 1.00 74.78  ? 46  GLU A N   1 
ATOM 361  C CA  . GLU A 1 46  ? 104.247 220.940 65.098 1.00 73.98  ? 46  GLU A CA  1 
ATOM 362  C C   . GLU A 1 46  ? 105.751 220.796 65.360 1.00 69.76  ? 46  GLU A C   1 
ATOM 363  O O   . GLU A 1 46  ? 106.335 221.633 66.059 1.00 69.13  ? 46  GLU A O   1 
ATOM 364  C CB  . GLU A 1 46  ? 103.412 220.031 65.999 1.00 78.31  ? 46  GLU A CB  1 
ATOM 365  C CG  . GLU A 1 46  ? 103.614 220.276 67.491 1.00 80.00  ? 46  GLU A CG  1 
ATOM 366  C CD  . GLU A 1 46  ? 102.559 219.628 68.376 1.00 89.18  ? 46  GLU A CD  1 
ATOM 367  O OE1 . GLU A 1 46  ? 102.115 218.499 68.039 1.00 93.79  ? 46  GLU A OE1 1 
ATOM 368  O OE2 . GLU A 1 46  ? 102.193 220.235 69.418 1.00 90.96  ? 46  GLU A OE2 1 
ATOM 369  N N   . VAL A 1 47  ? 106.380 219.763 64.816 1.00 66.18  ? 47  VAL A N   1 
ATOM 370  C CA  . VAL A 1 47  ? 107.822 219.608 64.900 1.00 66.31  ? 47  VAL A CA  1 
ATOM 371  C C   . VAL A 1 47  ? 108.534 220.670 64.052 1.00 67.84  ? 47  VAL A C   1 
ATOM 372  O O   . VAL A 1 47  ? 109.594 221.157 64.438 1.00 63.59  ? 47  VAL A O   1 
ATOM 373  C CB  . VAL A 1 47  ? 108.216 218.180 64.488 1.00 64.24  ? 47  VAL A CB  1 
ATOM 374  C CG1 . VAL A 1 47  ? 109.708 217.967 64.330 1.00 64.20  ? 47  VAL A CG1 1 
ATOM 375  C CG2 . VAL A 1 47  ? 107.699 217.186 65.505 1.00 66.18  ? 47  VAL A CG2 1 
ATOM 376  N N   . ALA A 1 48  ? 107.956 221.051 62.907 1.00 69.67  ? 48  ALA A N   1 
ATOM 377  C CA  . ALA A 1 48  ? 108.528 222.093 62.073 1.00 68.08  ? 48  ALA A CA  1 
ATOM 378  C C   . ALA A 1 48  ? 108.587 223.407 62.855 1.00 64.05  ? 48  ALA A C   1 
ATOM 379  O O   . ALA A 1 48  ? 109.592 224.104 62.788 1.00 63.77  ? 48  ALA A O   1 
ATOM 380  C CB  . ALA A 1 48  ? 107.749 222.215 60.774 1.00 67.87  ? 48  ALA A CB  1 
ATOM 381  N N   . ARG A 1 49  ? 107.543 223.739 63.614 1.00 63.61  ? 49  ARG A N   1 
ATOM 382  C CA  . ARG A 1 49  ? 107.517 224.981 64.370 1.00 59.74  ? 49  ARG A CA  1 
ATOM 383  C C   . ARG A 1 49  ? 108.523 224.941 65.526 1.00 59.36  ? 49  ARG A C   1 
ATOM 384  O O   . ARG A 1 49  ? 109.143 225.945 65.847 1.00 62.75  ? 49  ARG A O   1 
ATOM 385  C CB  . ARG A 1 49  ? 106.100 225.311 64.821 1.00 60.72  ? 49  ARG A CB  1 
ATOM 386  C CG  . ARG A 1 49  ? 106.023 226.620 65.593 1.00 65.51  ? 49  ARG A CG  1 
ATOM 387  C CD  . ARG A 1 49  ? 104.593 227.074 65.817 1.00 73.10  ? 49  ARG A CD  1 
ATOM 388  N NE  . ARG A 1 49  ? 103.957 227.591 64.599 1.00 72.86  ? 49  ARG A NE  1 
ATOM 389  C CZ  . ARG A 1 49  ? 104.044 228.834 64.150 1.00 77.61  ? 49  ARG A CZ  1 
ATOM 390  N NH1 . ARG A 1 49  ? 103.424 229.162 63.028 1.00 85.07  ? 49  ARG A NH1 1 
ATOM 391  N NH2 . ARG A 1 49  ? 104.740 229.757 64.798 1.00 77.84  ? 49  ARG A NH2 1 
ATOM 392  N N   . ILE A 1 50  ? 108.729 223.809 66.158 1.00 58.90  ? 50  ILE A N   1 
ATOM 393  C CA  . ILE A 1 50  ? 109.742 223.703 67.191 1.00 53.12  ? 50  ILE A CA  1 
ATOM 394  C C   . ILE A 1 50  ? 111.131 223.969 66.605 1.00 59.22  ? 50  ILE A C   1 
ATOM 395  O O   . ILE A 1 50  ? 111.921 224.675 67.222 1.00 61.47  ? 50  ILE A O   1 
ATOM 396  C CB  . ILE A 1 50  ? 109.654 222.332 67.883 1.00 56.17  ? 50  ILE A CB  1 
ATOM 397  C CG1 . ILE A 1 50  ? 108.398 222.249 68.731 1.00 59.95  ? 50  ILE A CG1 1 
ATOM 398  C CG2 . ILE A 1 50  ? 110.892 221.997 68.714 1.00 57.95  ? 50  ILE A CG2 1 
ATOM 399  C CD1 . ILE A 1 50  ? 107.958 220.836 69.070 1.00 61.28  ? 50  ILE A CD1 1 
ATOM 400  N N   . HIS A 1 51  ? 111.474 223.415 65.448 1.00 60.50  ? 51  HIS A N   1 
ATOM 401  C CA  . HIS A 1 51  ? 112.762 223.680 64.836 1.00 60.40  ? 51  HIS A CA  1 
ATOM 402  C C   . HIS A 1 51  ? 112.845 225.119 64.340 1.00 56.25  ? 51  HIS A C   1 
ATOM 403  O O   . HIS A 1 51  ? 113.915 225.682 64.390 1.00 58.84  ? 51  HIS A O   1 
ATOM 404  C CB  . HIS A 1 51  ? 113.034 222.650 63.730 1.00 65.02  ? 51  HIS A CB  1 
ATOM 405  C CG  . HIS A 1 51  ? 113.187 221.272 64.269 1.00 61.07  ? 51  HIS A CG  1 
ATOM 406  N ND1 . HIS A 1 51  ? 114.129 220.889 65.194 1.00 63.75  ? 51  HIS A ND1 1 
ATOM 407  C CD2 . HIS A 1 51  ? 112.476 220.188 63.981 1.00 62.52  ? 51  HIS A CD2 1 
ATOM 408  C CE1 . HIS A 1 51  ? 113.972 219.600 65.453 1.00 66.10  ? 51  HIS A CE1 1 
ATOM 409  N NE2 . HIS A 1 51  ? 112.970 219.153 64.728 1.00 65.23  ? 51  HIS A NE2 1 
ATOM 410  N N   . ALA A 1 52  ? 111.760 225.698 63.834 1.00 57.65  ? 52  ALA A N   1 
ATOM 411  C CA  . ALA A 1 52  ? 111.780 227.074 63.371 1.00 58.66  ? 52  ALA A CA  1 
ATOM 412  C C   . ALA A 1 52  ? 112.106 228.012 64.527 1.00 58.50  ? 52  ALA A C   1 
ATOM 413  O O   . ALA A 1 52  ? 112.896 228.930 64.367 1.00 58.65  ? 52  ALA A O   1 
ATOM 414  C CB  . ALA A 1 52  ? 110.466 227.427 62.727 1.00 59.08  ? 52  ALA A CB  1 
ATOM 415  N N   . GLU A 1 53  ? 111.512 227.775 65.691 1.00 60.03  ? 53  GLU A N   1 
ATOM 416  C CA  . GLU A 1 53  ? 111.763 228.561 66.885 1.00 57.77  ? 53  GLU A CA  1 
ATOM 417  C C   . GLU A 1 53  ? 113.198 228.378 67.355 1.00 55.85  ? 53  GLU A C   1 
ATOM 418  O O   . GLU A 1 53  ? 113.797 229.351 67.788 1.00 57.89  ? 53  GLU A O   1 
ATOM 419  C CB  . GLU A 1 53  ? 110.728 228.200 67.946 1.00 58.76  ? 53  GLU A CB  1 
ATOM 420  C CG  . GLU A 1 53  ? 109.373 228.785 67.585 1.00 63.48  ? 53  GLU A CG  1 
ATOM 421  C CD  . GLU A 1 53  ? 108.207 228.378 68.475 1.00 75.77  ? 53  GLU A CD  1 
ATOM 422  O OE1 . GLU A 1 53  ? 108.438 227.577 69.437 1.00 77.59  ? 53  GLU A OE1 1 
ATOM 423  O OE2 . GLU A 1 53  ? 107.063 228.894 68.230 1.00 75.73  ? 53  GLU A OE2 1 
ATOM 424  N N   . ASN A 1 54  ? 113.750 227.175 67.297 1.00 54.16  ? 54  ASN A N   1 
ATOM 425  C CA  . ASN A 1 54  ? 115.143 226.964 67.635 1.00 52.18  ? 54  ASN A CA  1 
ATOM 426  C C   . ASN A 1 54  ? 116.046 227.707 66.658 1.00 55.05  ? 54  ASN A C   1 
ATOM 427  O O   . ASN A 1 54  ? 117.041 228.278 67.059 1.00 59.84  ? 54  ASN A O   1 
ATOM 428  C CB  . ASN A 1 54  ? 115.547 225.496 67.604 1.00 58.88  ? 54  ASN A CB  1 
ATOM 429  C CG  . ASN A 1 54  ? 115.017 224.676 68.753 1.00 60.57  ? 54  ASN A CG  1 
ATOM 430  O OD1 . ASN A 1 54  ? 114.603 225.213 69.783 1.00 65.51  ? 54  ASN A OD1 1 
ATOM 431  N ND2 . ASN A 1 54  ? 115.072 223.361 68.626 1.00 65.74  ? 54  ASN A ND2 1 
ATOM 432  N N   . ALA A 1 55  ? 115.760 227.681 65.362 1.00 58.56  ? 55  ALA A N   1 
ATOM 433  C CA  . ALA A 1 55  ? 116.635 228.280 64.377 1.00 56.20  ? 55  ALA A CA  1 
ATOM 434  C C   . ALA A 1 55  ? 116.677 229.785 64.613 1.00 52.06  ? 55  ALA A C   1 
ATOM 435  O O   . ALA A 1 55  ? 117.756 230.340 64.618 1.00 58.17  ? 55  ALA A O   1 
ATOM 436  C CB  . ALA A 1 55  ? 116.162 227.878 62.977 1.00 54.73  ? 55  ALA A CB  1 
ATOM 437  N N   . ILE A 1 56  ? 115.526 230.431 64.793 1.00 52.19  ? 56  ILE A N   1 
ATOM 438  C CA  . ILE A 1 56  ? 115.466 231.865 65.028 1.00 50.32  ? 56  ILE A CA  1 
ATOM 439  C C   . ILE A 1 56  ? 116.131 232.222 66.359 1.00 54.27  ? 56  ILE A C   1 
ATOM 440  O O   . ILE A 1 56  ? 116.855 233.201 66.407 1.00 55.64  ? 56  ILE A O   1 
ATOM 441  C CB  . ILE A 1 56  ? 114.019 232.336 64.949 1.00 50.95  ? 56  ILE A CB  1 
ATOM 442  C CG1 . ILE A 1 56  ? 113.497 232.220 63.517 1.00 56.55  ? 56  ILE A CG1 1 
ATOM 443  C CG2 . ILE A 1 56  ? 113.837 233.746 65.504 1.00 51.93  ? 56  ILE A CG2 1 
ATOM 444  C CD1 . ILE A 1 56  ? 114.242 233.045 62.484 1.00 55.14  ? 56  ILE A CD1 1 
ATOM 445  N N   . ARG A 1 57  ? 115.967 231.414 67.409 1.00 54.26  ? 57  ARG A N   1 
ATOM 446  C CA  . ARG A 1 57  ? 116.650 231.630 68.668 1.00 54.14  ? 57  ARG A CA  1 
ATOM 447  C C   . ARG A 1 57  ? 118.160 231.542 68.492 1.00 54.63  ? 57  ARG A C   1 
ATOM 448  O O   . ARG A 1 57  ? 118.875 232.392 68.997 1.00 58.59  ? 57  ARG A O   1 
ATOM 449  C CB  . ARG A 1 57  ? 116.192 230.637 69.741 1.00 57.67  ? 57  ARG A CB  1 
ATOM 450  C CG  . ARG A 1 57  ? 116.899 230.727 71.088 1.00 57.23  ? 57  ARG A CG  1 
ATOM 451  C CD  . ARG A 1 57  ? 116.243 229.931 72.164 1.00 56.77  ? 57  ARG A CD  1 
ATOM 452  N NE  . ARG A 1 57  ? 116.194 228.519 71.805 1.00 61.52  ? 57  ARG A NE  1 
ATOM 453  C CZ  . ARG A 1 57  ? 117.191 227.675 71.951 1.00 67.32  ? 57  ARG A CZ  1 
ATOM 454  N NH1 . ARG A 1 57  ? 117.005 226.413 71.551 1.00 66.10  ? 57  ARG A NH1 1 
ATOM 455  N NH2 . ARG A 1 57  ? 118.357 228.077 72.476 1.00 65.12  ? 57  ARG A NH2 1 
ATOM 456  N N   . GLN A 1 58  ? 118.667 230.522 67.833 1.00 55.43  ? 58  GLN A N   1 
ATOM 457  C CA  . GLN A 1 58  ? 120.110 230.341 67.683 1.00 58.45  ? 58  GLN A CA  1 
ATOM 458  C C   . GLN A 1 58  ? 120.680 231.489 66.849 1.00 55.49  ? 58  GLN A C   1 
ATOM 459  O O   . GLN A 1 58  ? 121.768 231.944 67.122 1.00 58.94  ? 58  GLN A O   1 
ATOM 460  C CB  . GLN A 1 58  ? 120.408 228.986 67.038 1.00 59.79  ? 58  GLN A CB  1 
ATOM 461  C CG  . GLN A 1 58  ? 119.935 227.804 67.867 1.00 61.46  ? 58  GLN A CG  1 
ATOM 462  C CD  . GLN A 1 58  ? 120.975 227.286 68.825 1.00 70.94  ? 58  GLN A CD  1 
ATOM 463  O OE1 . GLN A 1 58  ? 121.928 227.976 69.175 1.00 69.26  ? 58  GLN A OE1 1 
ATOM 464  N NE2 . GLN A 1 58  ? 120.830 226.030 69.224 1.00 79.84  ? 58  GLN A NE2 1 
ATOM 465  N N   . LYS A 1 59  ? 119.957 231.969 65.842 1.00 55.34  ? 59  LYS A N   1 
ATOM 466  C CA  . LYS A 1 59  ? 120.393 233.090 65.027 1.00 57.80  ? 59  LYS A CA  1 
ATOM 467  C C   . LYS A 1 59  ? 120.614 234.321 65.914 1.00 58.21  ? 59  LYS A C   1 
ATOM 468  O O   . LYS A 1 59  ? 121.694 234.895 65.936 1.00 59.80  ? 59  LYS A O   1 
ATOM 469  C CB  . LYS A 1 59  ? 119.346 233.358 63.939 1.00 61.37  ? 59  LYS A CB  1 
ATOM 470  C CG  . LYS A 1 59  ? 119.759 234.408 62.959 1.00 64.35  ? 59  LYS A CG  1 
ATOM 471  C CD  . LYS A 1 59  ? 118.726 234.681 61.881 1.00 70.37  ? 59  LYS A CD  1 
ATOM 472  C CE  . LYS A 1 59  ? 119.352 235.190 60.590 1.00 79.36  ? 59  LYS A CE  1 
ATOM 473  N NZ  . LYS A 1 59  ? 120.285 234.224 59.956 1.00 79.27  ? 59  LYS A NZ  1 
ATOM 474  N N   . ASN A 1 60  ? 119.576 234.723 66.636 1.00 57.08  ? 60  ASN A N   1 
ATOM 475  C CA  . ASN A 1 60  ? 119.606 235.885 67.479 1.00 52.66  ? 60  ASN A CA  1 
ATOM 476  C C   . ASN A 1 60  ? 120.597 235.734 68.632 1.00 55.47  ? 60  ASN A C   1 
ATOM 477  O O   . ASN A 1 60  ? 121.209 236.714 69.030 1.00 59.16  ? 60  ASN A O   1 
ATOM 478  C CB  . ASN A 1 60  ? 118.207 236.158 67.969 1.00 50.53  ? 60  ASN A CB  1 
ATOM 479  C CG  . ASN A 1 60  ? 117.373 236.746 66.867 1.00 56.57  ? 60  ASN A CG  1 
ATOM 480  O OD1 . ASN A 1 60  ? 117.713 237.804 66.329 1.00 62.85  ? 60  ASN A OD1 1 
ATOM 481  N ND2 . ASN A 1 60  ? 116.254 236.122 66.536 1.00 57.10  ? 60  ASN A ND2 1 
ATOM 482  N N   . GLN A 1 61  ? 120.744 234.552 69.201 1.00 54.13  ? 61  GLN A N   1 
ATOM 483  C CA  . GLN A 1 61  ? 121.762 234.355 70.205 1.00 56.41  ? 61  GLN A CA  1 
ATOM 484  C C   . GLN A 1 61  ? 123.137 234.633 69.613 1.00 57.81  ? 61  GLN A C   1 
ATOM 485  O O   . GLN A 1 61  ? 124.002 235.115 70.322 1.00 60.68  ? 61  GLN A O   1 
ATOM 486  C CB  . GLN A 1 61  ? 121.865 232.938 70.775 1.00 56.50  ? 61  GLN A CB  1 
ATOM 487  C CG  . GLN A 1 61  ? 120.837 232.663 71.854 1.00 57.19  ? 61  GLN A CG  1 
ATOM 488  C CD  . GLN A 1 61  ? 120.728 231.218 72.300 1.00 66.47  ? 61  GLN A CD  1 
ATOM 489  O OE1 . GLN A 1 61  ? 119.768 230.863 73.006 1.00 64.46  ? 61  GLN A OE1 1 
ATOM 490  N NE2 . GLN A 1 61  ? 121.670 230.362 71.904 1.00 65.65  ? 61  GLN A NE2 1 
ATOM 491  N N   . ALA A 1 62  ? 123.392 234.281 68.359 1.00 57.11  ? 62  ALA A N   1 
ATOM 492  C CA  . ALA A 1 62  ? 124.751 234.381 67.862 1.00 58.14  ? 62  ALA A CA  1 
ATOM 493  C C   . ALA A 1 62  ? 125.115 235.864 67.736 1.00 55.46  ? 62  ALA A C   1 
ATOM 494  O O   . ALA A 1 62  ? 126.220 236.253 68.044 1.00 56.75  ? 62  ALA A O   1 
ATOM 495  C CB  . ALA A 1 62  ? 124.912 233.611 66.555 1.00 58.25  ? 62  ALA A CB  1 
ATOM 496  N N   . VAL A 1 63  ? 124.185 236.697 67.303 1.00 56.31  ? 63  VAL A N   1 
ATOM 497  C CA  . VAL A 1 63  ? 124.439 238.120 67.227 1.00 55.66  ? 63  VAL A CA  1 
ATOM 498  C C   . VAL A 1 63  ? 124.768 238.674 68.609 1.00 58.75  ? 63  VAL A C   1 
ATOM 499  O O   . VAL A 1 63  ? 125.545 239.614 68.715 1.00 59.63  ? 63  VAL A O   1 
ATOM 500  C CB  . VAL A 1 63  ? 123.225 238.872 66.676 1.00 56.96  ? 63  VAL A CB  1 
ATOM 501  C CG1 . VAL A 1 63  ? 123.392 240.381 66.736 1.00 57.54  ? 63  VAL A CG1 1 
ATOM 502  C CG2 . VAL A 1 63  ? 122.934 238.450 65.256 1.00 64.56  ? 63  VAL A CG2 1 
ATOM 503  N N   . ASN A 1 64  ? 124.145 238.161 69.666 1.00 57.35  ? 64  ASN A N   1 
ATOM 504  C CA  . ASN A 1 64  ? 124.467 238.638 70.996 1.00 57.10  ? 64  ASN A CA  1 
ATOM 505  C C   . ASN A 1 64  ? 125.858 238.162 71.402 1.00 54.90  ? 64  ASN A C   1 
ATOM 506  O O   . ASN A 1 64  ? 126.616 238.932 71.964 1.00 57.74  ? 64  ASN A O   1 
ATOM 507  C CB  . ASN A 1 64  ? 123.413 238.262 72.019 1.00 51.34  ? 64  ASN A CB  1 
ATOM 508  C CG  . ASN A 1 64  ? 122.104 238.932 71.727 1.00 54.88  ? 64  ASN A CG  1 
ATOM 509  O OD1 . ASN A 1 64  ? 121.989 239.708 70.778 1.00 61.67  ? 64  ASN A OD1 1 
ATOM 510  N ND2 . ASN A 1 64  ? 121.076 238.578 72.479 1.00 68.33  ? 64  ASN A ND2 1 
ATOM 511  N N   . PHE A 1 65  ? 126.192 236.905 71.187 1.00 55.85  ? 65  PHE A N   1 
ATOM 512  C CA  . PHE A 1 65  ? 127.514 236.457 71.575 1.00 59.88  ? 65  PHE A CA  1 
ATOM 513  C C   . PHE A 1 65  ? 128.583 237.238 70.809 1.00 56.14  ? 65  PHE A C   1 
ATOM 514  O O   . PHE A 1 65  ? 129.671 237.473 71.305 1.00 57.11  ? 65  PHE A O   1 
ATOM 515  C CB  . PHE A 1 65  ? 127.703 234.958 71.359 1.00 59.76  ? 65  PHE A CB  1 
ATOM 516  C CG  . PHE A 1 65  ? 126.948 234.098 72.353 1.00 64.74  ? 65  PHE A CG  1 
ATOM 517  C CD1 . PHE A 1 65  ? 127.119 234.266 73.717 1.00 68.39  ? 65  PHE A CD1 1 
ATOM 518  C CD2 . PHE A 1 65  ? 126.069 233.109 71.927 1.00 66.70  ? 65  PHE A CD2 1 
ATOM 519  C CE1 . PHE A 1 65  ? 126.451 233.460 74.627 1.00 71.31  ? 65  PHE A CE1 1 
ATOM 520  C CE2 . PHE A 1 65  ? 125.399 232.313 72.841 1.00 67.52  ? 65  PHE A CE2 1 
ATOM 521  C CZ  . PHE A 1 65  ? 125.590 232.488 74.184 1.00 72.66  ? 65  PHE A CZ  1 
ATOM 522  N N   . LEU A 1 66  ? 128.278 237.630 69.593 1.00 56.51  ? 66  LEU A N   1 
ATOM 523  C CA  . LEU A 1 66  ? 129.289 238.166 68.723 1.00 54.27  ? 66  LEU A CA  1 
ATOM 524  C C   . LEU A 1 66  ? 129.580 239.574 69.193 1.00 55.90  ? 66  LEU A C   1 
ATOM 525  O O   . LEU A 1 66  ? 130.743 239.964 69.241 1.00 54.41  ? 66  LEU A O   1 
ATOM 526  C CB  . LEU A 1 66  ? 128.739 238.159 67.302 1.00 54.93  ? 66  LEU A CB  1 
ATOM 527  C CG  . LEU A 1 66  ? 129.736 238.466 66.198 1.00 53.39  ? 66  LEU A CG  1 
ATOM 528  C CD1 . LEU A 1 66  ? 130.574 237.233 65.997 1.00 55.06  ? 66  LEU A CD1 1 
ATOM 529  C CD2 . LEU A 1 66  ? 129.062 238.919 64.942 1.00 58.31  ? 66  LEU A CD2 1 
ATOM 530  N N   . ARG A 1 67  ? 128.508 240.313 69.487 1.00 55.93  ? 67  ARG A N   1 
ATOM 531  C CA  . ARG A 1 67  ? 128.601 241.683 69.948 1.00 54.99  ? 67  ARG A CA  1 
ATOM 532  C C   . ARG A 1 67  ? 129.273 241.748 71.315 1.00 52.63  ? 67  ARG A C   1 
ATOM 533  O O   . ARG A 1 67  ? 130.126 242.592 71.511 1.00 53.67  ? 67  ARG A O   1 
ATOM 534  C CB  . ARG A 1 67  ? 127.221 242.325 70.020 1.00 58.53  ? 67  ARG A CB  1 
ATOM 535  C CG  . ARG A 1 67  ? 127.270 243.746 70.533 1.00 61.71  ? 67  ARG A CG  1 
ATOM 536  C CD  . ARG A 1 67  ? 125.941 244.455 70.485 1.00 71.52  ? 67  ARG A CD  1 
ATOM 537  N NE  . ARG A 1 67  ? 124.779 243.595 70.744 1.00 74.59  ? 67  ARG A NE  1 
ATOM 538  C CZ  . ARG A 1 67  ? 123.820 243.346 69.846 1.00 79.51  ? 67  ARG A CZ  1 
ATOM 539  N NH1 . ARG A 1 67  ? 122.813 242.556 70.206 1.00 81.88  ? 67  ARG A NH1 1 
ATOM 540  N NH2 . ARG A 1 67  ? 123.834 243.885 68.614 1.00 76.64  ? 67  ARG A NH2 1 
ATOM 541  N N   . MET A 1 68  ? 128.934 240.885 72.258 1.00 54.31  ? 68  MET A N   1 
ATOM 542  C CA  . MET A 1 68  ? 129.661 240.878 73.512 1.00 52.52  ? 68  MET A CA  1 
ATOM 543  C C   . MET A 1 68  ? 131.104 240.481 73.285 1.00 51.69  ? 68  MET A C   1 
ATOM 544  O O   . MET A 1 68  ? 131.955 240.934 74.019 1.00 53.63  ? 68  MET A O   1 
ATOM 545  C CB  . MET A 1 68  ? 129.122 239.913 74.575 1.00 60.97  ? 68  MET A CB  1 
ATOM 546  C CG  . MET A 1 68  ? 127.825 240.402 75.176 1.00 71.70  ? 68  MET A CG  1 
ATOM 547  S SD  . MET A 1 68  ? 127.064 239.277 76.367 1.00 98.04  ? 68  MET A SD  1 
ATOM 548  C CE  . MET A 1 68  ? 125.329 239.593 75.978 1.00 101.65 ? 68  MET A CE  1 
ATOM 549  N N   . SER A 1 69  ? 131.424 239.643 72.321 1.00 53.02  ? 69  SER A N   1 
ATOM 550  C CA  . SER A 1 69  ? 132.832 239.347 72.107 1.00 52.92  ? 69  SER A CA  1 
ATOM 551  C C   . SER A 1 69  ? 133.567 240.618 71.671 1.00 51.69  ? 69  SER A C   1 
ATOM 552  O O   . SER A 1 69  ? 134.721 240.826 72.000 1.00 57.22  ? 69  SER A O   1 
ATOM 553  C CB  . SER A 1 69  ? 133.022 238.245 71.116 1.00 54.17  ? 69  SER A CB  1 
ATOM 554  O OG  . SER A 1 69  ? 134.319 237.695 71.232 1.00 59.28  ? 69  SER A OG  1 
ATOM 555  N N   . ALA A 1 70  ? 132.904 241.478 70.929 1.00 48.89  ? 70  ALA A N   1 
ATOM 556  C CA  . ALA A 1 70  ? 133.533 242.655 70.399 1.00 47.51  ? 70  ALA A CA  1 
ATOM 557  C C   . ALA A 1 70  ? 133.852 243.599 71.540 1.00 53.74  ? 70  ALA A C   1 
ATOM 558  O O   . ALA A 1 70  ? 134.795 244.383 71.453 1.00 53.36  ? 70  ALA A O   1 
ATOM 559  C CB  . ALA A 1 70  ? 132.624 243.335 69.393 1.00 47.46  ? 70  ALA A CB  1 
ATOM 560  N N   . ARG A 1 71  ? 132.966 243.603 72.531 1.00 52.98  ? 71  ARG A N   1 
ATOM 561  C CA  . ARG A 1 71  ? 133.073 244.509 73.646 1.00 47.05  ? 71  ARG A CA  1 
ATOM 562  C C   . ARG A 1 71  ? 134.205 244.018 74.527 1.00 48.77  ? 71  ARG A C   1 
ATOM 563  O O   . ARG A 1 71  ? 135.065 244.787 74.918 1.00 51.79  ? 71  ARG A O   1 
ATOM 564  C CB  . ARG A 1 71  ? 131.717 244.572 74.327 1.00 50.22  ? 71  ARG A CB  1 
ATOM 565  C CG  . ARG A 1 71  ? 130.684 245.300 73.483 1.00 54.51  ? 71  ARG A CG  1 
ATOM 566  C CD  . ARG A 1 71  ? 131.015 246.745 73.320 1.00 54.01  ? 71  ARG A CD  1 
ATOM 567  N NE  . ARG A 1 71  ? 129.918 247.457 72.679 1.00 60.78  ? 71  ARG A NE  1 
ATOM 568  C CZ  . ARG A 1 71  ? 129.530 247.284 71.420 1.00 70.88  ? 71  ARG A CZ  1 
ATOM 569  N NH1 . ARG A 1 71  ? 128.359 247.786 71.031 1.00 68.86  ? 71  ARG A NH1 1 
ATOM 570  N NH2 . ARG A 1 71  ? 130.266 246.558 70.578 1.00 66.74  ? 71  ARG A NH2 1 
ATOM 571  N N   . VAL A 1 72  ? 134.249 242.734 74.796 1.00 48.75  ? 72  VAL A N   1 
ATOM 572  C CA  . VAL A 1 72  ? 135.277 242.238 75.678 1.00 46.88  ? 72  VAL A CA  1 
ATOM 573  C C   . VAL A 1 72  ? 136.621 242.359 74.981 1.00 50.77  ? 72  VAL A C   1 
ATOM 574  O O   . VAL A 1 72  ? 137.611 242.601 75.631 1.00 53.75  ? 72  VAL A O   1 
ATOM 575  C CB  . VAL A 1 72  ? 134.969 240.811 76.143 1.00 46.28  ? 72  VAL A CB  1 
ATOM 576  C CG1 . VAL A 1 72  ? 136.029 240.247 77.071 1.00 51.58  ? 72  VAL A CG1 1 
ATOM 577  C CG2 . VAL A 1 72  ? 133.599 240.740 76.805 1.00 47.18  ? 72  VAL A CG2 1 
ATOM 578  N N   . ASP A 1 73  ? 136.681 242.230 73.668 1.00 55.95  ? 73  ASP A N   1 
ATOM 579  C CA  . ASP A 1 73  ? 137.923 242.445 72.958 1.00 56.14  ? 73  ASP A CA  1 
ATOM 580  C C   . ASP A 1 73  ? 138.396 243.886 73.106 1.00 53.70  ? 73  ASP A C   1 
ATOM 581  O O   . ASP A 1 73  ? 139.588 244.116 73.252 1.00 52.40  ? 73  ASP A O   1 
ATOM 582  C CB  . ASP A 1 73  ? 137.759 242.132 71.482 1.00 58.08  ? 73  ASP A CB  1 
ATOM 583  C CG  . ASP A 1 73  ? 138.375 240.808 71.067 1.00 71.47  ? 73  ASP A CG  1 
ATOM 584  O OD1 . ASP A 1 73  ? 139.370 240.383 71.756 1.00 69.76  ? 73  ASP A OD1 1 
ATOM 585  O OD2 . ASP A 1 73  ? 137.837 240.192 70.085 1.00 77.93  ? 73  ASP A OD2 1 
ATOM 586  N N   . ALA A 1 74  ? 137.492 244.854 72.960 1.00 48.91  ? 74  ALA A N   1 
ATOM 587  C CA  . ALA A 1 74  ? 137.893 246.241 73.072 1.00 47.83  ? 74  ALA A CA  1 
ATOM 588  C C   . ALA A 1 74  ? 138.514 246.505 74.445 1.00 50.93  ? 74  ALA A C   1 
ATOM 589  O O   . ALA A 1 74  ? 139.569 247.106 74.536 1.00 52.29  ? 74  ALA A O   1 
ATOM 590  C CB  . ALA A 1 74  ? 136.750 247.145 72.848 1.00 47.32  ? 74  ALA A CB  1 
ATOM 591  N N   . VAL A 1 75  ? 137.873 246.043 75.505 1.00 51.72  ? 75  VAL A N   1 
ATOM 592  C CA  . VAL A 1 75  ? 138.412 246.183 76.833 1.00 48.53  ? 75  VAL A CA  1 
ATOM 593  C C   . VAL A 1 75  ? 139.801 245.566 76.871 1.00 48.99  ? 75  VAL A C   1 
ATOM 594  O O   . VAL A 1 75  ? 140.704 246.155 77.436 1.00 51.59  ? 75  VAL A O   1 
ATOM 595  C CB  . VAL A 1 75  ? 137.489 245.530 77.872 1.00 51.04  ? 75  VAL A CB  1 
ATOM 596  C CG1 . VAL A 1 75  ? 138.178 245.260 79.213 1.00 56.72  ? 75  VAL A CG1 1 
ATOM 597  C CG2 . VAL A 1 75  ? 136.249 246.361 78.079 1.00 51.08  ? 75  VAL A CG2 1 
ATOM 598  N N   . ALA A 1 76  ? 139.974 244.365 76.357 1.00 51.29  ? 76  ALA A N   1 
ATOM 599  C CA  . ALA A 1 76  ? 141.251 243.688 76.497 1.00 49.94  ? 76  ALA A CA  1 
ATOM 600  C C   . ALA A 1 76  ? 142.339 244.444 75.740 1.00 49.77  ? 76  ALA A C   1 
ATOM 601  O O   . ALA A 1 76  ? 143.515 244.298 76.021 1.00 52.27  ? 76  ALA A O   1 
ATOM 602  C CB  . ALA A 1 76  ? 141.140 242.283 76.004 1.00 48.79  ? 76  ALA A CB  1 
ATOM 603  N N   . ALA A 1 77  ? 141.952 245.237 74.754 1.00 51.65  ? 77  ALA A N   1 
ATOM 604  C CA  . ALA A 1 77  ? 142.927 245.966 73.972 1.00 52.85  ? 77  ALA A CA  1 
ATOM 605  C C   . ALA A 1 77  ? 143.481 247.101 74.822 1.00 53.22  ? 77  ALA A C   1 
ATOM 606  O O   . ALA A 1 77  ? 144.659 247.429 74.757 1.00 55.64  ? 77  ALA A O   1 
ATOM 607  C CB  . ALA A 1 77  ? 142.275 246.507 72.728 1.00 54.00  ? 77  ALA A CB  1 
ATOM 608  N N   . ARG A 1 78  ? 142.589 247.705 75.586 1.00 51.96  ? 78  ARG A N   1 
ATOM 609  C CA  . ARG A 1 78  ? 142.888 248.834 76.424 1.00 50.53  ? 78  ARG A CA  1 
ATOM 610  C C   . ARG A 1 78  ? 143.740 248.348 77.599 1.00 51.99  ? 78  ARG A C   1 
ATOM 611  O O   . ARG A 1 78  ? 144.657 249.033 78.037 1.00 53.41  ? 78  ARG A O   1 
ATOM 612  C CB  . ARG A 1 78  ? 141.516 249.359 76.842 1.00 49.18  ? 78  ARG A CB  1 
ATOM 613  C CG  . ARG A 1 78  ? 141.339 250.859 76.846 1.00 56.16  ? 78  ARG A CG  1 
ATOM 614  C CD  . ARG A 1 78  ? 141.231 251.463 75.493 1.00 62.27  ? 78  ARG A CD  1 
ATOM 615  N NE  . ARG A 1 78  ? 140.917 252.882 75.664 1.00 62.80  ? 78  ARG A NE  1 
ATOM 616  C CZ  . ARG A 1 78  ? 141.769 253.799 76.111 1.00 70.37  ? 78  ARG A CZ  1 
ATOM 617  N NH1 . ARG A 1 78  ? 141.291 254.937 76.587 1.00 74.70  ? 78  ARG A NH1 1 
ATOM 618  N NH2 . ARG A 1 78  ? 143.077 253.570 76.164 1.00 68.88  ? 78  ARG A NH2 1 
ATOM 619  N N   . VAL A 1 79  ? 143.434 247.182 78.145 1.00 48.07  ? 79  VAL A N   1 
ATOM 620  C CA  . VAL A 1 79  ? 144.208 246.665 79.248 1.00 43.60  ? 79  VAL A CA  1 
ATOM 621  C C   . VAL A 1 79  ? 145.594 246.287 78.746 1.00 51.45  ? 79  VAL A C   1 
ATOM 622  O O   . VAL A 1 79  ? 146.516 246.163 79.541 1.00 51.95  ? 79  VAL A O   1 
ATOM 623  C CB  . VAL A 1 79  ? 143.501 245.463 79.896 1.00 42.82  ? 79  VAL A CB  1 
ATOM 624  C CG1 . VAL A 1 79  ? 144.378 244.712 80.890 1.00 46.23  ? 79  VAL A CG1 1 
ATOM 625  C CG2 . VAL A 1 79  ? 142.184 245.875 80.551 1.00 42.05  ? 79  VAL A CG2 1 
ATOM 626  N N   . GLN A 1 80  ? 145.754 246.020 77.450 1.00 52.97  ? 80  GLN A N   1 
ATOM 627  C CA  . GLN A 1 80  ? 147.069 245.701 76.920 1.00 54.81  ? 80  GLN A CA  1 
ATOM 628  C C   . GLN A 1 80  ? 147.895 246.984 76.895 1.00 54.03  ? 80  GLN A C   1 
ATOM 629  O O   . GLN A 1 80  ? 149.096 246.959 77.137 1.00 53.97  ? 80  GLN A O   1 
ATOM 630  C CB  . GLN A 1 80  ? 146.995 245.164 75.490 1.00 57.59  ? 80  GLN A CB  1 
ATOM 631  C CG  . GLN A 1 80  ? 148.331 244.750 74.887 1.00 55.94  ? 80  GLN A CG  1 
ATOM 632  C CD  . GLN A 1 80  ? 148.916 243.547 75.583 1.00 59.45  ? 80  GLN A CD  1 
ATOM 633  O OE1 . GLN A 1 80  ? 148.545 242.403 75.295 1.00 67.23  ? 80  GLN A OE1 1 
ATOM 634  N NE2 . GLN A 1 80  ? 149.854 243.791 76.490 1.00 60.62  ? 80  GLN A NE2 1 
ATOM 635  N N   . THR A 1 81  ? 147.259 248.121 76.589 1.00 50.90  ? 81  THR A N   1 
ATOM 636  C CA  . THR A 1 81  ? 147.938 249.438 76.517 1.00 51.76  ? 81  THR A CA  1 
ATOM 637  C C   . THR A 1 81  ? 148.389 249.836 77.899 1.00 53.38  ? 81  THR A C   1 
ATOM 638  O O   . THR A 1 81  ? 149.399 250.540 77.993 1.00 56.38  ? 81  THR A O   1 
ATOM 639  C CB  . THR A 1 81  ? 146.971 250.464 75.933 1.00 53.36  ? 81  THR A CB  1 
ATOM 640  O OG1 . THR A 1 81  ? 146.679 250.000 74.619 1.00 55.71  ? 81  THR A OG1 1 
ATOM 641  C CG2 . THR A 1 81  ? 147.574 251.855 75.888 1.00 58.68  ? 81  THR A CG2 1 
ATOM 642  N N   . ALA A 1 82  ? 147.608 249.507 78.924 1.00 54.06  ? 82  ALA A N   1 
ATOM 643  C CA  . ALA A 1 82  ? 147.964 249.747 80.297 1.00 48.72  ? 82  ALA A CA  1 
ATOM 644  C C   . ALA A 1 82  ? 149.069 248.792 80.725 1.00 45.85  ? 82  ALA A C   1 
ATOM 645  O O   . ALA A 1 82  ? 149.946 249.200 81.454 1.00 54.09  ? 82  ALA A O   1 
ATOM 646  C CB  . ALA A 1 82  ? 146.725 249.621 81.160 1.00 50.04  ? 82  ALA A CB  1 
ATOM 647  N N   . VAL A 1 83  ? 149.057 247.539 80.318 1.00 49.69  ? 83  VAL A N   1 
ATOM 648  C CA  . VAL A 1 83  ? 150.114 246.641 80.760 1.00 50.60  ? 83  VAL A CA  1 
ATOM 649  C C   . VAL A 1 83  ? 151.450 247.075 80.166 1.00 53.59  ? 83  VAL A C   1 
ATOM 650  O O   . VAL A 1 83  ? 152.442 247.123 80.877 1.00 55.94  ? 83  VAL A O   1 
ATOM 651  C CB  . VAL A 1 83  ? 149.842 245.160 80.472 1.00 46.28  ? 83  VAL A CB  1 
ATOM 652  C CG1 . VAL A 1 83  ? 151.089 244.309 80.457 1.00 54.92  ? 83  VAL A CG1 1 
ATOM 653  C CG2 . VAL A 1 83  ? 148.881 244.582 81.480 1.00 50.68  ? 83  VAL A CG2 1 
ATOM 654  N N   . THR A 1 84  ? 151.479 247.414 78.886 1.00 55.36  ? 84  THR A N   1 
ATOM 655  C CA  . THR A 1 84  ? 152.725 247.759 78.229 1.00 54.51  ? 84  THR A CA  1 
ATOM 656  C C   . THR A 1 84  ? 153.191 249.135 78.690 1.00 56.37  ? 84  THR A C   1 
ATOM 657  O O   . THR A 1 84  ? 154.369 249.289 78.964 1.00 56.97  ? 84  THR A O   1 
ATOM 658  C CB  . THR A 1 84  ? 152.571 247.687 76.712 1.00 54.92  ? 84  THR A CB  1 
ATOM 659  O OG1 . THR A 1 84  ? 152.229 246.327 76.473 1.00 60.29  ? 84  THR A OG1 1 
ATOM 660  C CG2 . THR A 1 84  ? 153.873 247.802 75.956 1.00 60.49  ? 84  THR A CG2 1 
ATOM 661  N N   . MET A 1 85  ? 152.326 250.136 78.793 1.00 56.79  ? 85  MET A N   1 
ATOM 662  C CA  . MET A 1 85  ? 152.864 251.432 79.149 1.00 57.00  ? 85  MET A CA  1 
ATOM 663  C C   . MET A 1 85  ? 153.292 251.444 80.606 1.00 55.18  ? 85  MET A C   1 
ATOM 664  O O   . MET A 1 85  ? 154.159 252.214 80.981 1.00 56.02  ? 85  MET A O   1 
ATOM 665  C CB  . MET A 1 85  ? 151.894 252.580 78.876 1.00 60.06  ? 85  MET A CB  1 
ATOM 666  C CG  . MET A 1 85  ? 151.658 252.752 77.375 1.00 69.82  ? 85  MET A CG  1 
ATOM 667  S SD  . MET A 1 85  ? 153.081 252.611 76.256 1.00 78.51  ? 85  MET A SD  1 
ATOM 668  C CE  . MET A 1 85  ? 153.816 254.168 76.795 1.00 72.81  ? 85  MET A CE  1 
ATOM 669  N N   . GLY A 1 86  ? 152.709 250.592 81.423 1.00 53.91  ? 86  GLY A N   1 
ATOM 670  C CA  . GLY A 1 86  ? 153.199 250.430 82.770 1.00 50.64  ? 86  GLY A CA  1 
ATOM 671  C C   . GLY A 1 86  ? 154.624 249.882 82.792 1.00 53.90  ? 86  GLY A C   1 
ATOM 672  O O   . GLY A 1 86  ? 155.416 250.310 83.618 1.00 56.33  ? 86  GLY A O   1 
ATOM 673  N N   . LYS A 1 87  ? 154.937 248.913 81.932 1.00 53.94  ? 87  LYS A N   1 
ATOM 674  C CA  . LYS A 1 87  ? 156.288 248.393 81.829 1.00 55.18  ? 87  LYS A CA  1 
ATOM 675  C C   . LYS A 1 87  ? 157.271 249.452 81.323 1.00 53.63  ? 87  LYS A C   1 
ATOM 676  O O   . LYS A 1 87  ? 158.426 249.445 81.712 1.00 54.83  ? 87  LYS A O   1 
ATOM 677  C CB  . LYS A 1 87  ? 156.319 247.197 80.881 1.00 54.15  ? 87  LYS A CB  1 
ATOM 678  C CG  . LYS A 1 87  ? 155.993 245.936 81.598 1.00 59.04  ? 87  LYS A CG  1 
ATOM 679  C CD  . LYS A 1 87  ? 155.561 244.811 80.675 1.00 65.63  ? 87  LYS A CD  1 
ATOM 680  C CE  . LYS A 1 87  ? 155.191 243.592 81.481 1.00 75.76  ? 87  LYS A CE  1 
ATOM 681  N NZ  . LYS A 1 87  ? 155.145 242.409 80.610 1.00 80.40  ? 87  LYS A NZ  1 
ATOM 682  N N   . VAL A 1 88  ? 156.849 250.270 80.379 1.00 52.04  ? 88  VAL A N   1 
ATOM 683  C CA  . VAL A 1 88  ? 157.729 251.252 79.797 1.00 53.40  ? 88  VAL A CA  1 
ATOM 684  C C   . VAL A 1 88  ? 157.978 252.316 80.862 1.00 54.15  ? 88  VAL A C   1 
ATOM 685  O O   . VAL A 1 88  ? 159.087 252.799 81.020 1.00 53.30  ? 88  VAL A O   1 
ATOM 686  C CB  . VAL A 1 88  ? 157.141 251.835 78.493 1.00 52.77  ? 88  VAL A CB  1 
ATOM 687  C CG1 . VAL A 1 88  ? 157.795 253.132 78.058 1.00 54.60  ? 88  VAL A CG1 1 
ATOM 688  C CG2 . VAL A 1 88  ? 157.222 250.832 77.363 1.00 54.45  ? 88  VAL A CG2 1 
ATOM 689  N N   . THR A 1 89  ? 156.950 252.686 81.608 1.00 56.22  ? 89  THR A N   1 
ATOM 690  C CA  . THR A 1 89  ? 157.112 253.737 82.594 1.00 55.18  ? 89  THR A CA  1 
ATOM 691  C C   . THR A 1 89  ? 158.074 253.234 83.658 1.00 52.91  ? 89  THR A C   1 
ATOM 692  O O   . THR A 1 89  ? 158.932 253.958 84.124 1.00 53.63  ? 89  THR A O   1 
ATOM 693  C CB  . THR A 1 89  ? 155.768 254.136 83.189 1.00 55.53  ? 89  THR A CB  1 
ATOM 694  O OG1 . THR A 1 89  ? 154.944 254.656 82.148 1.00 54.75  ? 89  THR A OG1 1 
ATOM 695  C CG2 . THR A 1 89  ? 155.907 255.265 84.183 1.00 59.68  ? 89  THR A CG2 1 
ATOM 696  N N   . LYS A 1 90  ? 157.966 251.979 84.035 1.00 54.97  ? 90  LYS A N   1 
ATOM 697  C CA  . LYS A 1 90  ? 158.886 251.486 85.032 1.00 53.67  ? 90  LYS A CA  1 
ATOM 698  C C   . LYS A 1 90  ? 160.305 251.520 84.494 1.00 54.92  ? 90  LYS A C   1 
ATOM 699  O O   . LYS A 1 90  ? 161.197 251.878 85.250 1.00 57.19  ? 90  LYS A O   1 
ATOM 700  C CB  . LYS A 1 90  ? 158.525 250.107 85.570 1.00 55.02  ? 90  LYS A CB  1 
ATOM 701  C CG  . LYS A 1 90  ? 157.432 250.289 86.596 1.00 63.63  ? 90  LYS A CG  1 
ATOM 702  C CD  . LYS A 1 90  ? 157.182 249.111 87.531 1.00 73.53  ? 90  LYS A CD  1 
ATOM 703  C CE  . LYS A 1 90  ? 156.158 249.529 88.582 1.00 79.75  ? 90  LYS A CE  1 
ATOM 704  N NZ  . LYS A 1 90  ? 155.531 248.399 89.297 1.00 84.29  ? 90  LYS A NZ  1 
ATOM 705  N N   . SER A 1 91  ? 160.532 251.146 83.240 1.00 53.21  ? 91  SER A N   1 
ATOM 706  C CA  . SER A 1 91  ? 161.884 251.097 82.721 1.00 52.27  ? 91  SER A CA  1 
ATOM 707  C C   . SER A 1 91  ? 162.458 252.500 82.572 1.00 52.04  ? 91  SER A C   1 
ATOM 708  O O   . SER A 1 91  ? 163.640 252.684 82.788 1.00 53.15  ? 91  SER A O   1 
ATOM 709  C CB  . SER A 1 91  ? 161.960 250.363 81.429 1.00 51.74  ? 91  SER A CB  1 
ATOM 710  O OG  . SER A 1 91  ? 162.052 248.977 81.730 1.00 58.45  ? 91  SER A OG  1 
ATOM 711  N N   . MET A 1 92  ? 161.650 253.468 82.182 1.00 49.71  ? 92  MET A N   1 
ATOM 712  C CA  . MET A 1 92  ? 162.148 254.817 82.066 1.00 48.63  ? 92  MET A CA  1 
ATOM 713  C C   . MET A 1 92  ? 162.509 255.342 83.449 1.00 51.03  ? 92  MET A C   1 
ATOM 714  O O   . MET A 1 92  ? 163.512 256.013 83.620 1.00 51.48  ? 92  MET A O   1 
ATOM 715  C CB  . MET A 1 92  ? 161.128 255.752 81.406 1.00 49.11  ? 92  MET A CB  1 
ATOM 716  C CG  . MET A 1 92  ? 161.067 255.481 79.942 1.00 49.98  ? 92  MET A CG  1 
ATOM 717  S SD  . MET A 1 92  ? 159.973 256.538 78.994 1.00 58.14  ? 92  MET A SD  1 
ATOM 718  C CE  . MET A 1 92  ? 160.679 258.188 79.116 1.00 59.60  ? 92  MET A CE  1 
ATOM 719  N N   . ALA A 1 93  ? 161.679 255.064 84.436 1.00 53.70  ? 93  ALA A N   1 
ATOM 720  C CA  . ALA A 1 93  ? 161.962 255.534 85.769 1.00 50.90  ? 93  ALA A CA  1 
ATOM 721  C C   . ALA A 1 93  ? 163.277 254.940 86.235 1.00 49.43  ? 93  ALA A C   1 
ATOM 722  O O   . ALA A 1 93  ? 163.988 255.585 86.989 1.00 54.77  ? 93  ALA A O   1 
ATOM 723  C CB  . ALA A 1 93  ? 160.845 255.177 86.695 1.00 52.96  ? 93  ALA A CB  1 
ATOM 724  N N   . GLY A 1 94  ? 163.600 253.741 85.791 1.00 50.45  ? 94  GLY A N   1 
ATOM 725  C CA  . GLY A 1 94  ? 164.848 253.112 86.165 1.00 52.47  ? 94  GLY A CA  1 
ATOM 726  C C   . GLY A 1 94  ? 166.038 253.723 85.431 1.00 51.41  ? 94  GLY A C   1 
ATOM 727  O O   . GLY A 1 94  ? 167.109 253.868 85.992 1.00 55.42  ? 94  GLY A O   1 
ATOM 728  N N   . VAL A 1 95  ? 165.871 254.042 84.165 1.00 51.74  ? 95  VAL A N   1 
ATOM 729  C CA  . VAL A 1 95  ? 166.922 254.686 83.416 1.00 51.68  ? 95  VAL A CA  1 
ATOM 730  C C   . VAL A 1 95  ? 167.197 256.046 84.040 1.00 50.63  ? 95  VAL A C   1 
ATOM 731  O O   . VAL A 1 95  ? 168.341 256.437 84.153 1.00 53.60  ? 95  VAL A O   1 
ATOM 732  C CB  . VAL A 1 95  ? 166.499 254.799 81.944 1.00 49.04  ? 95  VAL A CB  1 
ATOM 733  C CG1 . VAL A 1 95  ? 167.269 255.864 81.194 1.00 53.61  ? 95  VAL A CG1 1 
ATOM 734  C CG2 . VAL A 1 95  ? 166.637 253.463 81.250 1.00 51.31  ? 95  VAL A CG2 1 
ATOM 735  N N   . VAL A 1 96  ? 166.154 256.755 84.437 1.00 49.76  ? 96  VAL A N   1 
ATOM 736  C CA  . VAL A 1 96  ? 166.311 258.083 84.984 1.00 49.04  ? 96  VAL A CA  1 
ATOM 737  C C   . VAL A 1 96  ? 167.099 257.985 86.272 1.00 51.68  ? 96  VAL A C   1 
ATOM 738  O O   . VAL A 1 96  ? 167.940 258.831 86.537 1.00 54.08  ? 96  VAL A O   1 
ATOM 739  C CB  . VAL A 1 96  ? 164.974 258.784 85.246 1.00 47.50  ? 96  VAL A CB  1 
ATOM 740  C CG1 . VAL A 1 96  ? 165.096 259.945 86.215 1.00 49.53  ? 96  VAL A CG1 1 
ATOM 741  C CG2 . VAL A 1 96  ? 164.375 259.250 83.942 1.00 49.97  ? 96  VAL A CG2 1 
ATOM 742  N N   . LYS A 1 97  ? 166.857 256.955 87.064 1.00 51.63  ? 97  LYS A N   1 
ATOM 743  C CA  . LYS A 1 97  ? 167.525 256.940 88.345 1.00 54.98  ? 97  LYS A CA  1 
ATOM 744  C C   . LYS A 1 97  ? 168.949 256.423 88.201 1.00 54.57  ? 97  LYS A C   1 
ATOM 745  O O   . LYS A 1 97  ? 169.813 256.839 88.974 1.00 57.38  ? 97  LYS A O   1 
ATOM 746  C CB  . LYS A 1 97  ? 166.819 256.152 89.446 1.00 54.30  ? 97  LYS A CB  1 
ATOM 747  C CG  . LYS A 1 97  ? 167.265 254.767 89.576 1.00 54.86  ? 97  LYS A CG  1 
ATOM 748  C CD  . LYS A 1 97  ? 166.676 254.212 90.859 1.00 66.04  ? 97  LYS A CD  1 
ATOM 749  C CE  . LYS A 1 97  ? 167.516 254.384 92.068 1.00 71.29  ? 97  LYS A CE  1 
ATOM 750  N NZ  . LYS A 1 97  ? 167.014 253.529 93.154 1.00 73.64  ? 97  LYS A NZ  1 
ATOM 751  N N   . SER A 1 98  ? 169.219 255.527 87.264 1.00 51.51  ? 98  SER A N   1 
ATOM 752  C CA  . SER A 1 98  ? 170.589 255.074 87.143 1.00 53.64  ? 98  SER A CA  1 
ATOM 753  C C   . SER A 1 98  ? 171.450 256.173 86.504 1.00 56.45  ? 98  SER A C   1 
ATOM 754  O O   . SER A 1 98  ? 172.635 256.275 86.789 1.00 56.69  ? 98  SER A O   1 
ATOM 755  C CB  . SER A 1 98  ? 170.681 253.803 86.379 1.00 51.42  ? 98  SER A CB  1 
ATOM 756  O OG  . SER A 1 98  ? 170.394 254.138 85.033 1.00 56.85  ? 98  SER A OG  1 
ATOM 757  N N   . MET A 1 99  ? 170.887 257.000 85.633 1.00 52.53  ? 99  MET A N   1 
ATOM 758  C CA  . MET A 1 99  ? 171.703 258.042 85.060 1.00 52.70  ? 99  MET A CA  1 
ATOM 759  C C   . MET A 1 99  ? 171.921 259.174 86.062 1.00 57.22  ? 99  MET A C   1 
ATOM 760  O O   . MET A 1 99  ? 172.862 259.950 85.958 1.00 55.92  ? 99  MET A O   1 
ATOM 761  C CB  . MET A 1 99  ? 171.076 258.587 83.784 1.00 52.96  ? 99  MET A CB  1 
ATOM 762  C CG  . MET A 1 99  ? 171.368 257.715 82.631 1.00 53.76  ? 99  MET A CG  1 
ATOM 763  S SD  . MET A 1 99  ? 170.534 258.341 81.179 1.00 57.53  ? 99  MET A SD  1 
ATOM 764  C CE  . MET A 1 99  ? 171.558 259.702 80.603 1.00 58.44  ? 99  MET A CE  1 
ATOM 765  N N   . ASP A 1 100 ? 171.006 259.312 87.007 1.00 58.91  ? 100 ASP A N   1 
ATOM 766  C CA  . ASP A 1 100 ? 171.136 260.344 88.009 1.00 58.31  ? 100 ASP A CA  1 
ATOM 767  C C   . ASP A 1 100 ? 172.341 259.994 88.863 1.00 58.68  ? 100 ASP A C   1 
ATOM 768  O O   . ASP A 1 100 ? 173.027 260.892 89.330 1.00 60.34  ? 100 ASP A O   1 
ATOM 769  C CB  . ASP A 1 100 ? 169.881 260.424 88.848 1.00 57.92  ? 100 ASP A CB  1 
ATOM 770  C CG  . ASP A 1 100 ? 169.921 261.405 90.002 1.00 64.62  ? 100 ASP A CG  1 
ATOM 771  O OD1 . ASP A 1 100 ? 169.892 262.633 89.735 1.00 69.38  ? 100 ASP A OD1 1 
ATOM 772  O OD2 . ASP A 1 100 ? 169.983 260.932 91.157 1.00 66.37  ? 100 ASP A OD2 1 
ATOM 773  N N   . ALA A 1 101 ? 172.557 258.688 89.060 1.00 56.49  ? 101 ALA A N   1 
ATOM 774  C CA  . ALA A 1 101 ? 173.682 258.207 89.840 1.00 53.05  ? 101 ALA A CA  1 
ATOM 775  C C   . ALA A 1 101 ? 174.976 258.483 89.092 1.00 57.26  ? 101 ALA A C   1 
ATOM 776  O O   . ALA A 1 101 ? 175.835 259.164 89.626 1.00 59.26  ? 101 ALA A O   1 
ATOM 777  C CB  . ALA A 1 101 ? 173.572 256.741 90.143 1.00 52.92  ? 101 ALA A CB  1 
ATOM 778  N N   . THR A 1 102 ? 175.084 257.922 87.881 1.00 57.22  ? 102 THR A N   1 
ATOM 779  C CA  . THR A 1 102 ? 176.296 257.993 87.039 1.00 53.15  ? 102 THR A CA  1 
ATOM 780  C C   . THR A 1 102 ? 176.699 259.413 86.744 1.00 52.89  ? 102 THR A C   1 
ATOM 781  O O   . THR A 1 102 ? 177.907 259.632 86.575 1.00 58.98  ? 102 THR A O   1 
ATOM 782  C CB  . THR A 1 102 ? 175.993 257.240 85.746 1.00 56.77  ? 102 THR A CB  1 
ATOM 783  O OG1 . THR A 1 102 ? 176.045 255.861 86.098 1.00 58.38  ? 102 THR A OG1 1 
ATOM 784  C CG2 . THR A 1 102 ? 176.992 257.546 84.645 1.00 60.33  ? 102 THR A CG2 1 
ATOM 785  N N   . LEU A 1 103 ? 175.746 260.333 86.589 1.00 54.87  ? 103 LEU A N   1 
ATOM 786  C CA  . LEU A 1 103 ? 176.121 261.677 86.218 1.00 54.65  ? 103 LEU A CA  1 
ATOM 787  C C   . LEU A 1 103 ? 176.629 262.397 87.454 1.00 57.85  ? 103 LEU A C   1 
ATOM 788  O O   . LEU A 1 103 ? 177.041 263.552 87.340 1.00 59.74  ? 103 LEU A O   1 
ATOM 789  C CB  . LEU A 1 103 ? 174.966 262.482 85.621 1.00 57.33  ? 103 LEU A CB  1 
ATOM 790  C CG  . LEU A 1 103 ? 174.317 261.975 84.322 1.00 59.64  ? 103 LEU A CG  1 
ATOM 791  C CD1 . LEU A 1 103 ? 173.134 262.872 84.001 1.00 58.07  ? 103 LEU A CD1 1 
ATOM 792  C CD2 . LEU A 1 103 ? 175.232 261.933 83.111 1.00 64.76  ? 103 LEU A CD2 1 
ATOM 793  N N   . LYS A 1 104 ? 176.466 261.795 88.636 1.00 57.15  ? 104 LYS A N   1 
ATOM 794  C CA  . LYS A 1 104 ? 176.967 262.391 89.860 1.00 55.95  ? 104 LYS A CA  1 
ATOM 795  C C   . LYS A 1 104 ? 178.396 261.923 90.055 1.00 56.12  ? 104 LYS A C   1 
ATOM 796  O O   . LYS A 1 104 ? 179.307 262.741 90.135 1.00 60.94  ? 104 LYS A O   1 
ATOM 797  C CB  . LYS A 1 104 ? 176.159 261.991 91.092 1.00 60.93  ? 104 LYS A CB  1 
ATOM 798  C CG  . LYS A 1 104 ? 175.244 263.073 91.582 1.00 64.29  ? 104 LYS A CG  1 
ATOM 799  C CD  . LYS A 1 104 ? 174.521 262.653 92.851 1.00 70.71  ? 104 LYS A CD  1 
ATOM 800  C CE  . LYS A 1 104 ? 173.139 263.275 92.941 1.00 78.22  ? 104 LYS A CE  1 
ATOM 801  N NZ  . LYS A 1 104 ? 172.128 262.667 92.052 1.00 73.38  ? 104 LYS A NZ  1 
ATOM 802  N N   . THR A 1 105 ? 178.613 260.618 90.064 1.00 50.46  ? 105 THR A N   1 
ATOM 803  C CA  . THR A 1 105 ? 179.963 260.160 90.244 1.00 51.97  ? 105 THR A CA  1 
ATOM 804  C C   . THR A 1 105 ? 180.867 260.481 89.046 1.00 60.84  ? 105 THR A C   1 
ATOM 805  O O   . THR A 1 105 ? 182.083 260.429 89.197 1.00 63.69  ? 105 THR A O   1 
ATOM 806  C CB  . THR A 1 105 ? 179.963 258.679 90.551 1.00 58.09  ? 105 THR A CB  1 
ATOM 807  O OG1 . THR A 1 105 ? 179.250 258.031 89.513 1.00 61.99  ? 105 THR A OG1 1 
ATOM 808  C CG2 . THR A 1 105 ? 179.246 258.404 91.850 1.00 65.26  ? 105 THR A CG2 1 
ATOM 809  N N   . MET A 1 106 ? 180.332 260.818 87.876 1.00 56.25  ? 106 MET A N   1 
ATOM 810  C CA  . MET A 1 106 ? 181.152 261.318 86.797 1.00 54.17  ? 106 MET A CA  1 
ATOM 811  C C   . MET A 1 106 ? 180.533 262.575 86.220 1.00 54.79  ? 106 MET A C   1 
ATOM 812  O O   . MET A 1 106 ? 180.024 262.552 85.113 1.00 60.41  ? 106 MET A O   1 
ATOM 813  C CB  . MET A 1 106 ? 181.215 260.292 85.665 1.00 63.18  ? 106 MET A CB  1 
ATOM 814  C CG  . MET A 1 106 ? 182.466 259.470 85.621 1.00 67.58  ? 106 MET A CG  1 
ATOM 815  S SD  . MET A 1 106 ? 183.810 260.499 85.007 1.00 75.66  ? 106 MET A SD  1 
ATOM 816  C CE  . MET A 1 106 ? 185.137 259.325 85.296 1.00 81.80  ? 106 MET A CE  1 
ATOM 817  N N   . ASN A 1 107 ? 180.578 263.675 86.937 1.00 53.56  ? 107 ASN A N   1 
ATOM 818  C CA  . ASN A 1 107 ? 179.956 264.875 86.429 1.00 53.53  ? 107 ASN A CA  1 
ATOM 819  C C   . ASN A 1 107 ? 180.812 265.497 85.323 1.00 53.23  ? 107 ASN A C   1 
ATOM 820  O O   . ASN A 1 107 ? 181.880 265.015 85.011 1.00 53.16  ? 107 ASN A O   1 
ATOM 821  C CB  . ASN A 1 107 ? 179.606 265.810 87.577 1.00 55.83  ? 107 ASN A CB  1 
ATOM 822  C CG  . ASN A 1 107 ? 180.820 266.248 88.350 1.00 56.05  ? 107 ASN A CG  1 
ATOM 823  O OD1 . ASN A 1 107 ? 181.485 267.207 87.962 1.00 55.77  ? 107 ASN A OD1 1 
ATOM 824  N ND2 . ASN A 1 107 ? 181.138 265.549 89.427 1.00 64.18  ? 107 ASN A ND2 1 
ATOM 825  N N   . LEU A 1 108 ? 180.320 266.591 84.737 1.00 52.47  ? 108 LEU A N   1 
ATOM 826  C CA  . LEU A 1 108 ? 180.949 267.188 83.576 1.00 50.63  ? 108 LEU A CA  1 
ATOM 827  C C   . LEU A 1 108 ? 182.303 267.789 83.908 1.00 55.48  ? 108 LEU A C   1 
ATOM 828  O O   . LEU A 1 108 ? 183.185 267.821 83.054 1.00 56.03  ? 108 LEU A O   1 
ATOM 829  C CB  . LEU A 1 108 ? 180.041 268.256 82.971 1.00 53.52  ? 108 LEU A CB  1 
ATOM 830  C CG  . LEU A 1 108 ? 178.748 267.742 82.316 1.00 50.81  ? 108 LEU A CG  1 
ATOM 831  C CD1 . LEU A 1 108 ? 178.098 268.847 81.541 1.00 50.87  ? 108 LEU A CD1 1 
ATOM 832  C CD2 . LEU A 1 108 ? 178.968 266.560 81.407 1.00 47.90  ? 108 LEU A CD2 1 
ATOM 833  N N   . GLU A 1 109 ? 182.450 268.323 85.115 1.00 56.55  ? 109 GLU A N   1 
ATOM 834  C CA  . GLU A 1 109 ? 183.703 268.913 85.513 1.00 53.95  ? 109 GLU A CA  1 
ATOM 835  C C   . GLU A 1 109 ? 184.749 267.823 85.672 1.00 54.10  ? 109 GLU A C   1 
ATOM 836  O O   . GLU A 1 109 ? 185.936 268.045 85.429 1.00 57.00  ? 109 GLU A O   1 
ATOM 837  C CB  . GLU A 1 109 ? 183.557 269.615 86.851 1.00 59.93  ? 109 GLU A CB  1 
ATOM 838  C CG  . GLU A 1 109 ? 182.954 271.003 86.737 1.00 62.32  ? 109 GLU A CG  1 
ATOM 839  C CD  . GLU A 1 109 ? 183.166 271.841 87.997 1.00 76.58  ? 109 GLU A CD  1 
ATOM 840  O OE1 . GLU A 1 109 ? 184.030 271.481 88.849 1.00 75.51  ? 109 GLU A OE1 1 
ATOM 841  O OE2 . GLU A 1 109 ? 182.438 272.874 88.138 1.00 78.90  ? 109 GLU A OE2 1 
ATOM 842  N N   . LYS A 1 110 ? 184.331 266.659 86.130 1.00 52.63  ? 110 LYS A N   1 
ATOM 843  C CA  . LYS A 1 110 ? 185.287 265.586 86.307 1.00 51.55  ? 110 LYS A CA  1 
ATOM 844  C C   . LYS A 1 110 ? 185.678 264.963 84.971 1.00 50.69  ? 110 LYS A C   1 
ATOM 845  O O   . LYS A 1 110 ? 186.777 264.479 84.862 1.00 55.24  ? 110 LYS A O   1 
ATOM 846  C CB  . LYS A 1 110 ? 184.637 264.662 87.324 1.00 52.98  ? 110 LYS A CB  1 
ATOM 847  C CG  . LYS A 1 110 ? 185.257 263.322 87.616 1.00 55.06  ? 110 LYS A CG  1 
ATOM 848  C CD  . LYS A 1 110 ? 184.859 263.031 89.066 1.00 61.41  ? 110 LYS A CD  1 
ATOM 849  C CE  . LYS A 1 110 ? 185.219 261.686 89.583 1.00 68.29  ? 110 LYS A CE  1 
ATOM 850  N NZ  . LYS A 1 110 ? 184.307 261.310 90.680 1.00 70.18  ? 110 LYS A NZ  1 
ATOM 851  N N   . ILE A 1 111 ? 184.780 264.935 83.983 1.00 55.72  ? 111 ILE A N   1 
ATOM 852  C CA  . ILE A 1 111 ? 185.039 264.454 82.633 1.00 52.96  ? 111 ILE A CA  1 
ATOM 853  C C   . ILE A 1 111 ? 185.984 265.460 81.996 1.00 50.63  ? 111 ILE A C   1 
ATOM 854  O O   . ILE A 1 111 ? 186.942 265.081 81.352 1.00 53.74  ? 111 ILE A O   1 
ATOM 855  C CB  . ILE A 1 111 ? 183.709 264.292 81.842 1.00 56.66  ? 111 ILE A CB  1 
ATOM 856  C CG1 . ILE A 1 111 ? 182.850 263.129 82.335 1.00 59.01  ? 111 ILE A CG1 1 
ATOM 857  C CG2 . ILE A 1 111 ? 183.890 264.181 80.326 1.00 58.77  ? 111 ILE A CG2 1 
ATOM 858  C CD1 . ILE A 1 111 ? 183.322 261.762 81.923 1.00 60.72  ? 111 ILE A CD1 1 
ATOM 859  N N   . SER A 1 112 ? 185.712 266.742 82.190 1.00 53.10  ? 112 SER A N   1 
ATOM 860  C CA  . SER A 1 112 ? 186.581 267.780 81.675 1.00 52.88  ? 112 SER A CA  1 
ATOM 861  C C   . SER A 1 112 ? 188.015 267.472 82.050 1.00 55.21  ? 112 SER A C   1 
ATOM 862  O O   . SER A 1 112 ? 188.912 267.619 81.233 1.00 59.65  ? 112 SER A O   1 
ATOM 863  C CB  . SER A 1 112 ? 186.238 269.146 82.190 1.00 54.51  ? 112 SER A CB  1 
ATOM 864  O OG  . SER A 1 112 ? 185.240 269.749 81.387 1.00 58.95  ? 112 SER A OG  1 
ATOM 865  N N   . ALA A 1 113 ? 188.203 267.099 83.310 1.00 55.08  ? 113 ALA A N   1 
ATOM 866  C CA  . ALA A 1 113 ? 189.520 266.902 83.858 1.00 50.60  ? 113 ALA A CA  1 
ATOM 867  C C   . ALA A 1 113 ? 190.125 265.636 83.282 1.00 51.85  ? 113 ALA A C   1 
ATOM 868  O O   . ALA A 1 113 ? 191.262 265.654 82.819 1.00 57.20  ? 113 ALA A O   1 
ATOM 869  C CB  . ALA A 1 113 ? 189.405 266.851 85.342 1.00 56.94  ? 113 ALA A CB  1 
ATOM 870  N N   . LEU A 1 114 ? 189.379 264.546 83.317 1.00 53.33  ? 114 LEU A N   1 
ATOM 871  C CA  . LEU A 1 114 ? 189.840 263.282 82.763 1.00 54.06  ? 114 LEU A CA  1 
ATOM 872  C C   . LEU A 1 114 ? 190.247 263.398 81.302 1.00 55.01  ? 114 LEU A C   1 
ATOM 873  O O   . LEU A 1 114 ? 191.135 262.690 80.871 1.00 56.68  ? 114 LEU A O   1 
ATOM 874  C CB  . LEU A 1 114 ? 188.716 262.273 82.869 1.00 54.11  ? 114 LEU A CB  1 
ATOM 875  C CG  . LEU A 1 114 ? 189.070 260.858 82.439 1.00 59.20  ? 114 LEU A CG  1 
ATOM 876  C CD1 . LEU A 1 114 ? 189.903 260.325 83.590 1.00 65.09  ? 114 LEU A CD1 1 
ATOM 877  C CD2 . LEU A 1 114 ? 187.868 259.962 82.170 1.00 65.21  ? 114 LEU A CD2 1 
ATOM 878  N N   . MET A 1 115 ? 189.536 264.205 80.521 1.00 56.68  ? 115 MET A N   1 
ATOM 879  C CA  . MET A 1 115 ? 189.800 264.318 79.103 1.00 55.99  ? 115 MET A CA  1 
ATOM 880  C C   . MET A 1 115 ? 191.078 265.105 78.908 1.00 54.95  ? 115 MET A C   1 
ATOM 881  O O   . MET A 1 115 ? 191.903 264.737 78.088 1.00 56.75  ? 115 MET A O   1 
ATOM 882  C CB  . MET A 1 115 ? 188.681 265.081 78.378 1.00 59.84  ? 115 MET A CB  1 
ATOM 883  C CG  . MET A 1 115 ? 187.378 264.322 78.159 1.00 56.14  ? 115 MET A CG  1 
ATOM 884  S SD  . MET A 1 115 ? 187.580 262.728 77.354 1.00 57.45  ? 115 MET A SD  1 
ATOM 885  C CE  . MET A 1 115 ? 187.563 261.600 78.750 1.00 65.69  ? 115 MET A CE  1 
ATOM 886  N N   . ASP A 1 116 ? 191.213 266.194 79.661 1.00 57.78  ? 116 ASP A N   1 
ATOM 887  C CA  . ASP A 1 116 ? 192.404 267.015 79.614 1.00 57.72  ? 116 ASP A CA  1 
ATOM 888  C C   . ASP A 1 116 ? 193.635 266.180 79.901 1.00 57.76  ? 116 ASP A C   1 
ATOM 889  O O   . ASP A 1 116 ? 194.654 266.364 79.252 1.00 58.85  ? 116 ASP A O   1 
ATOM 890  C CB  . ASP A 1 116 ? 192.342 268.130 80.629 1.00 56.12  ? 116 ASP A CB  1 
ATOM 891  C CG  . ASP A 1 116 ? 191.619 269.371 80.128 1.00 69.93  ? 116 ASP A CG  1 
ATOM 892  O OD1 . ASP A 1 116 ? 191.169 269.362 78.942 1.00 70.41  ? 116 ASP A OD1 1 
ATOM 893  O OD2 . ASP A 1 116 ? 191.508 270.347 80.922 1.00 74.82  ? 116 ASP A OD2 1 
ATOM 894  N N   . LYS A 1 117 ? 193.518 265.317 80.905 1.00 55.15  ? 117 LYS A N   1 
ATOM 895  C CA  . LYS A 1 117 ? 194.618 264.507 81.348 1.00 53.47  ? 117 LYS A CA  1 
ATOM 896  C C   . LYS A 1 117 ? 194.968 263.500 80.268 1.00 53.50  ? 117 LYS A C   1 
ATOM 897  O O   . LYS A 1 117 ? 196.136 263.361 79.957 1.00 57.09  ? 117 LYS A O   1 
ATOM 898  C CB  . LYS A 1 117 ? 194.279 263.829 82.680 1.00 57.28  ? 117 LYS A CB  1 
ATOM 899  C CG  . LYS A 1 117 ? 195.467 263.180 83.373 1.00 54.72  ? 117 LYS A CG  1 
ATOM 900  C CD  . LYS A 1 117 ? 195.225 262.810 84.823 1.00 57.65  ? 117 LYS A CD  1 
ATOM 901  C CE  . LYS A 1 117 ? 196.327 262.000 85.459 1.00 57.84  ? 117 LYS A CE  1 
ATOM 902  N NZ  . LYS A 1 117 ? 195.846 261.224 86.606 1.00 57.15  ? 117 LYS A NZ  1 
ATOM 903  N N   . PHE A 1 118 ? 193.976 262.794 79.732 1.00 55.49  ? 118 PHE A N   1 
ATOM 904  C CA  . PHE A 1 118 ? 194.145 261.855 78.625 1.00 55.76  ? 118 PHE A CA  1 
ATOM 905  C C   . PHE A 1 118 ? 194.928 262.487 77.479 1.00 53.48  ? 118 PHE A C   1 
ATOM 906  O O   . PHE A 1 118 ? 195.829 261.895 76.922 1.00 53.92  ? 118 PHE A O   1 
ATOM 907  C CB  . PHE A 1 118 ? 192.745 261.454 78.139 1.00 54.65  ? 118 PHE A CB  1 
ATOM 908  C CG  . PHE A 1 118 ? 192.731 260.530 76.943 1.00 52.25  ? 118 PHE A CG  1 
ATOM 909  C CD1 . PHE A 1 118 ? 192.769 261.051 75.656 1.00 54.29  ? 118 PHE A CD1 1 
ATOM 910  C CD2 . PHE A 1 118 ? 192.658 259.155 77.118 1.00 50.16  ? 118 PHE A CD2 1 
ATOM 911  C CE1 . PHE A 1 118 ? 192.791 260.199 74.568 1.00 55.56  ? 118 PHE A CE1 1 
ATOM 912  C CE2 . PHE A 1 118 ? 192.698 258.307 76.033 1.00 51.45  ? 118 PHE A CE2 1 
ATOM 913  C CZ  . PHE A 1 118 ? 192.757 258.829 74.765 1.00 55.43  ? 118 PHE A CZ  1 
ATOM 914  N N   . GLU A 1 119 ? 194.532 263.688 77.108 1.00 56.03  ? 119 GLU A N   1 
ATOM 915  C CA  . GLU A 1 119 ? 195.191 264.401 76.043 1.00 58.97  ? 119 GLU A CA  1 
ATOM 916  C C   . GLU A 1 119 ? 196.647 264.650 76.414 1.00 59.17  ? 119 GLU A C   1 
ATOM 917  O O   . GLU A 1 119 ? 197.536 264.455 75.600 1.00 60.95  ? 119 GLU A O   1 
ATOM 918  C CB  . GLU A 1 119 ? 194.404 265.687 75.895 1.00 62.22  ? 119 GLU A CB  1 
ATOM 919  C CG  . GLU A 1 119 ? 195.150 266.795 75.166 1.00 67.47  ? 119 GLU A CG  1 
ATOM 920  C CD  . GLU A 1 119 ? 194.702 266.954 73.742 1.00 76.90  ? 119 GLU A CD  1 
ATOM 921  O OE1 . GLU A 1 119 ? 194.287 265.899 73.204 1.00 77.64  ? 119 GLU A OE1 1 
ATOM 922  O OE2 . GLU A 1 119 ? 194.713 268.099 73.203 1.00 77.13  ? 119 GLU A OE2 1 
ATOM 923  N N   . HIS A 1 120 ? 196.895 265.140 77.623 1.00 60.37  ? 120 HIS A N   1 
ATOM 924  C CA  . HIS A 1 120 ? 198.220 265.602 77.982 1.00 62.25  ? 120 HIS A CA  1 
ATOM 925  C C   . HIS A 1 120 ? 199.126 264.393 78.139 1.00 58.96  ? 120 HIS A C   1 
ATOM 926  O O   . HIS A 1 120 ? 200.279 264.448 77.753 1.00 62.92  ? 120 HIS A O   1 
ATOM 927  C CB  . HIS A 1 120 ? 198.192 266.501 79.222 1.00 65.25  ? 120 HIS A CB  1 
ATOM 928  C CG  . HIS A 1 120 ? 199.535 266.588 79.886 1.00 72.12  ? 120 HIS A CG  1 
ATOM 929  N ND1 . HIS A 1 120 ? 200.596 267.319 79.369 1.00 73.65  ? 120 HIS A ND1 1 
ATOM 930  C CD2 . HIS A 1 120 ? 200.008 265.981 81.017 1.00 70.23  ? 120 HIS A CD2 1 
ATOM 931  C CE1 . HIS A 1 120 ? 201.655 267.185 80.167 1.00 75.34  ? 120 HIS A CE1 1 
ATOM 932  N NE2 . HIS A 1 120 ? 201.323 266.374 81.174 1.00 74.87  ? 120 HIS A NE2 1 
ATOM 933  N N   . GLN A 1 121 ? 198.603 263.296 78.650 1.00 56.39  ? 121 GLN A N   1 
ATOM 934  C CA  . GLN A 1 121 ? 199.419 262.111 78.791 1.00 52.25  ? 121 GLN A CA  1 
ATOM 935  C C   . GLN A 1 121 ? 199.867 261.541 77.456 1.00 55.83  ? 121 GLN A C   1 
ATOM 936  O O   . GLN A 1 121 ? 200.956 260.988 77.403 1.00 60.60  ? 121 GLN A O   1 
ATOM 937  C CB  . GLN A 1 121 ? 198.727 260.985 79.536 1.00 51.86  ? 121 GLN A CB  1 
ATOM 938  C CG  . GLN A 1 121 ? 198.541 261.323 81.009 1.00 49.47  ? 121 GLN A CG  1 
ATOM 939  C CD  . GLN A 1 121 ? 197.982 260.148 81.754 1.00 53.68  ? 121 GLN A CD  1 
ATOM 940  O OE1 . GLN A 1 121 ? 197.664 259.108 81.173 1.00 59.76  ? 121 GLN A OE1 1 
ATOM 941  N NE2 . GLN A 1 121 ? 197.892 260.281 83.059 1.00 60.40  ? 121 GLN A NE2 1 
ATOM 942  N N   . PHE A 1 122 ? 199.069 261.635 76.395 1.00 55.37  ? 122 PHE A N   1 
ATOM 943  C CA  . PHE A 1 122 ? 199.465 261.053 75.122 1.00 52.70  ? 122 PHE A CA  1 
ATOM 944  C C   . PHE A 1 122 ? 200.444 261.995 74.450 1.00 54.12  ? 122 PHE A C   1 
ATOM 945  O O   . PHE A 1 122 ? 201.173 261.583 73.565 1.00 61.15  ? 122 PHE A O   1 
ATOM 946  C CB  . PHE A 1 122 ? 198.310 260.729 74.166 1.00 54.87  ? 122 PHE A CB  1 
ATOM 947  C CG  . PHE A 1 122 ? 197.736 259.354 74.428 1.00 50.29  ? 122 PHE A CG  1 
ATOM 948  C CD1 . PHE A 1 122 ? 198.401 258.235 73.974 1.00 54.01  ? 122 PHE A CD1 1 
ATOM 949  C CD2 . PHE A 1 122 ? 196.598 259.178 75.188 1.00 53.41  ? 122 PHE A CD2 1 
ATOM 950  C CE1 . PHE A 1 122 ? 197.925 256.970 74.230 1.00 53.00  ? 122 PHE A CE1 1 
ATOM 951  C CE2 . PHE A 1 122 ? 196.151 257.901 75.474 1.00 59.18  ? 122 PHE A CE2 1 
ATOM 952  C CZ  . PHE A 1 122 ? 196.803 256.798 74.977 1.00 53.24  ? 122 PHE A CZ  1 
ATOM 953  N N   . GLU A 1 123 ? 200.461 263.253 74.858 1.00 55.71  ? 123 GLU A N   1 
ATOM 954  C CA  . GLU A 1 123 ? 201.519 264.129 74.405 1.00 60.52  ? 123 GLU A CA  1 
ATOM 955  C C   . GLU A 1 123 ? 202.839 263.666 75.003 1.00 58.23  ? 123 GLU A C   1 
ATOM 956  O O   . GLU A 1 123 ? 203.843 263.721 74.320 1.00 60.82  ? 123 GLU A O   1 
ATOM 957  C CB  . GLU A 1 123 ? 201.291 265.599 74.748 1.00 63.67  ? 123 GLU A CB  1 
ATOM 958  C CG  . GLU A 1 123 ? 200.174 266.256 73.947 1.00 66.72  ? 123 GLU A CG  1 
ATOM 959  C CD  . GLU A 1 123 ? 199.705 267.632 74.434 1.00 79.16  ? 123 GLU A CD  1 
ATOM 960  O OE1 . GLU A 1 123 ? 200.315 268.169 75.400 1.00 82.97  ? 123 GLU A OE1 1 
ATOM 961  O OE2 . GLU A 1 123 ? 198.724 268.198 73.863 1.00 78.16  ? 123 GLU A OE2 1 
ATOM 962  N N   . THR A 1 124 ? 202.856 263.212 76.261 1.00 58.91  ? 124 THR A N   1 
ATOM 963  C CA  . THR A 1 124 ? 204.128 262.806 76.828 1.00 60.78  ? 124 THR A CA  1 
ATOM 964  C C   . THR A 1 124 ? 204.554 261.505 76.162 1.00 59.31  ? 124 THR A C   1 
ATOM 965  O O   . THR A 1 124 ? 205.741 261.315 75.969 1.00 61.05  ? 124 THR A O   1 
ATOM 966  C CB  . THR A 1 124 ? 204.186 262.662 78.350 1.00 61.26  ? 124 THR A CB  1 
ATOM 967  O OG1 . THR A 1 124 ? 203.671 261.376 78.668 1.00 63.17  ? 124 THR A OG1 1 
ATOM 968  C CG2 . THR A 1 124 ? 203.490 263.796 79.080 1.00 65.92  ? 124 THR A CG2 1 
ATOM 969  N N   . LEU A 1 125 ? 203.624 260.633 75.808 1.00 56.06  ? 125 LEU A N   1 
ATOM 970  C CA  . LEU A 1 125 ? 203.998 259.409 75.142 1.00 57.70  ? 125 LEU A CA  1 
ATOM 971  C C   . LEU A 1 125 ? 204.577 259.680 73.757 1.00 59.99  ? 125 LEU A C   1 
ATOM 972  O O   . LEU A 1 125 ? 205.414 258.917 73.293 1.00 62.90  ? 125 LEU A O   1 
ATOM 973  C CB  . LEU A 1 125 ? 202.796 258.486 75.027 1.00 62.61  ? 125 LEU A CB  1 
ATOM 974  C CG  . LEU A 1 125 ? 203.105 257.095 74.466 1.00 62.24  ? 125 LEU A CG  1 
ATOM 975  C CD1 . LEU A 1 125 ? 203.895 256.278 75.463 1.00 64.63  ? 125 LEU A CD1 1 
ATOM 976  C CD2 . LEU A 1 125 ? 201.851 256.366 74.081 1.00 65.82  ? 125 LEU A CD2 1 
ATOM 977  N N   . ASP A 1 126 ? 204.102 260.710 73.073 1.00 60.12  ? 126 ASP A N   1 
ATOM 978  C CA  . ASP A 1 126 ? 204.655 261.076 71.790 1.00 61.86  ? 126 ASP A CA  1 
ATOM 979  C C   . ASP A 1 126 ? 206.067 261.623 71.951 1.00 61.49  ? 126 ASP A C   1 
ATOM 980  O O   . ASP A 1 126 ? 206.888 261.469 71.060 1.00 63.62  ? 126 ASP A O   1 
ATOM 981  C CB  . ASP A 1 126 ? 203.777 262.093 71.084 1.00 66.32  ? 126 ASP A CB  1 
ATOM 982  C CG  . ASP A 1 126 ? 202.508 261.526 70.445 1.00 74.58  ? 126 ASP A CG  1 
ATOM 983  O OD1 . ASP A 1 126 ? 202.404 260.272 70.341 1.00 71.71  ? 126 ASP A OD1 1 
ATOM 984  O OD2 . ASP A 1 126 ? 201.625 262.342 70.024 1.00 77.60  ? 126 ASP A OD2 1 
ATOM 985  N N   . VAL A 1 127 ? 206.324 262.324 73.052 1.00 62.77  ? 127 VAL A N   1 
ATOM 986  C CA  . VAL A 1 127 ? 207.642 262.864 73.307 1.00 61.10  ? 127 VAL A CA  1 
ATOM 987  C C   . VAL A 1 127 ? 208.559 261.685 73.553 1.00 57.97  ? 127 VAL A C   1 
ATOM 988  O O   . VAL A 1 127 ? 209.673 261.683 73.062 1.00 64.50  ? 127 VAL A O   1 
ATOM 989  C CB  . VAL A 1 127 ? 207.652 263.872 74.468 1.00 59.75  ? 127 VAL A CB  1 
ATOM 990  C CG1 . VAL A 1 127 ? 209.060 264.143 74.979 1.00 64.70  ? 127 VAL A CG1 1 
ATOM 991  C CG2 . VAL A 1 127 ? 207.020 265.186 74.052 1.00 62.23  ? 127 VAL A CG2 1 
ATOM 992  N N   . GLN A 1 128 ? 208.054 260.687 74.263 1.00 58.37  ? 128 GLN A N   1 
ATOM 993  C CA  . GLN A 1 128 ? 208.821 259.513 74.611 1.00 56.26  ? 128 GLN A CA  1 
ATOM 994  C C   . GLN A 1 128 ? 209.168 258.688 73.383 1.00 59.10  ? 128 GLN A C   1 
ATOM 995  O O   . GLN A 1 128 ? 210.272 258.200 73.297 1.00 64.66  ? 128 GLN A O   1 
ATOM 996  C CB  . GLN A 1 128 ? 208.078 258.639 75.609 1.00 58.79  ? 128 GLN A CB  1 
ATOM 997  C CG  . GLN A 1 128 ? 208.634 257.226 75.728 1.00 60.45  ? 128 GLN A CG  1 
ATOM 998  C CD  . GLN A 1 128 ? 207.974 256.452 76.841 1.00 59.12  ? 128 GLN A CD  1 
ATOM 999  O OE1 . GLN A 1 128 ? 207.378 257.038 77.751 1.00 67.21  ? 128 GLN A OE1 1 
ATOM 1000 N NE2 . GLN A 1 128 ? 208.084 255.134 76.799 1.00 65.30  ? 128 GLN A NE2 1 
ATOM 1001 N N   . THR A 1 129 ? 208.258 258.491 72.434 1.00 63.65  ? 129 THR A N   1 
ATOM 1002 C CA  . THR A 1 129 ? 208.579 257.628 71.306 1.00 64.78  ? 129 THR A CA  1 
ATOM 1003 C C   . THR A 1 129 ? 209.542 258.345 70.372 1.00 61.15  ? 129 THR A C   1 
ATOM 1004 O O   . THR A 1 129 ? 210.294 257.696 69.679 1.00 66.08  ? 129 THR A O   1 
ATOM 1005 C CB  . THR A 1 129 ? 207.325 257.170 70.558 1.00 67.77  ? 129 THR A CB  1 
ATOM 1006 O OG1 . THR A 1 129 ? 206.663 258.325 70.052 1.00 64.42  ? 129 THR A OG1 1 
ATOM 1007 C CG2 . THR A 1 129 ? 206.391 256.380 71.459 1.00 70.02  ? 129 THR A CG2 1 
ATOM 1008 N N   . GLN A 1 130 ? 209.523 259.665 70.346 1.00 61.86  ? 130 GLN A N   1 
ATOM 1009 C CA  . GLN A 1 130 ? 210.423 260.390 69.476 1.00 67.45  ? 130 GLN A CA  1 
ATOM 1010 C C   . GLN A 1 130 ? 211.853 260.169 69.949 1.00 69.69  ? 130 GLN A C   1 
ATOM 1011 O O   . GLN A 1 130 ? 212.775 260.007 69.156 1.00 70.26  ? 130 GLN A O   1 
ATOM 1012 C CB  . GLN A 1 130 ? 210.096 261.881 69.491 1.00 68.61  ? 130 GLN A CB  1 
ATOM 1013 C CG  . GLN A 1 130 ? 210.955 262.710 68.549 1.00 71.04  ? 130 GLN A CG  1 
ATOM 1014 C CD  . GLN A 1 130 ? 210.814 262.262 67.109 1.00 78.23  ? 130 GLN A CD  1 
ATOM 1015 O OE1 . GLN A 1 130 ? 209.704 262.184 66.561 1.00 79.92  ? 130 GLN A OE1 1 
ATOM 1016 N NE2 . GLN A 1 130 ? 211.939 261.947 66.479 1.00 78.41  ? 130 GLN A NE2 1 
ATOM 1017 N N   . GLN A 1 131 ? 212.043 260.160 71.261 1.00 67.22  ? 131 GLN A N   1 
ATOM 1018 C CA  . GLN A 1 131 ? 213.392 260.092 71.768 1.00 70.15  ? 131 GLN A CA  1 
ATOM 1019 C C   . GLN A 1 131 ? 213.882 258.652 71.792 1.00 66.30  ? 131 GLN A C   1 
ATOM 1020 O O   . GLN A 1 131 ? 215.092 258.430 71.793 1.00 69.93  ? 131 GLN A O   1 
ATOM 1021 C CB  . GLN A 1 131 ? 213.493 260.813 73.107 1.00 73.18  ? 131 GLN A CB  1 
ATOM 1022 C CG  . GLN A 1 131 ? 212.783 260.158 74.275 1.00 67.70  ? 131 GLN A CG  1 
ATOM 1023 C CD  . GLN A 1 131 ? 213.087 260.959 75.523 1.00 80.46  ? 131 GLN A CD  1 
ATOM 1024 O OE1 . GLN A 1 131 ? 213.796 261.976 75.455 1.00 77.10  ? 131 GLN A OE1 1 
ATOM 1025 N NE2 . GLN A 1 131 ? 212.573 260.515 76.666 1.00 81.90  ? 131 GLN A NE2 1 
ATOM 1026 N N   . MET A 1 132 ? 212.975 257.688 71.785 1.00 63.59  ? 132 MET A N   1 
ATOM 1027 C CA  . MET A 1 132 ? 213.386 256.315 71.574 1.00 65.60  ? 132 MET A CA  1 
ATOM 1028 C C   . MET A 1 132 ? 213.828 256.132 70.129 1.00 66.93  ? 132 MET A C   1 
ATOM 1029 O O   . MET A 1 132 ? 214.868 255.533 69.882 1.00 66.74  ? 132 MET A O   1 
ATOM 1030 C CB  . MET A 1 132 ? 212.284 255.319 71.939 1.00 65.95  ? 132 MET A CB  1 
ATOM 1031 C CG  . MET A 1 132 ? 212.076 255.316 73.444 1.00 70.10  ? 132 MET A CG  1 
ATOM 1032 S SD  . MET A 1 132 ? 210.738 254.318 74.126 1.00 81.79  ? 132 MET A SD  1 
ATOM 1033 C CE  . MET A 1 132 ? 211.256 252.694 73.535 1.00 84.31  ? 132 MET A CE  1 
ATOM 1034 N N   . GLU A 1 133 ? 213.067 256.672 69.187 1.00 66.81  ? 133 GLU A N   1 
ATOM 1035 C CA  . GLU A 1 133 ? 213.384 256.517 67.783 1.00 67.37  ? 133 GLU A CA  1 
ATOM 1036 C C   . GLU A 1 133 ? 214.674 257.238 67.435 1.00 62.83  ? 133 GLU A C   1 
ATOM 1037 O O   . GLU A 1 133 ? 215.425 256.724 66.627 1.00 64.51  ? 133 GLU A O   1 
ATOM 1038 C CB  . GLU A 1 133 ? 212.221 257.031 66.935 1.00 70.37  ? 133 GLU A CB  1 
ATOM 1039 C CG  . GLU A 1 133 ? 211.010 256.104 67.004 1.00 70.67  ? 133 GLU A CG  1 
ATOM 1040 C CD  . GLU A 1 133 ? 209.863 256.470 66.075 1.00 78.31  ? 133 GLU A CD  1 
ATOM 1041 O OE1 . GLU A 1 133 ? 209.985 257.433 65.267 1.00 82.82  ? 133 GLU A OE1 1 
ATOM 1042 O OE2 . GLU A 1 133 ? 208.833 255.759 66.161 1.00 81.87  ? 133 GLU A OE2 1 
ATOM 1043 N N   . ASP A 1 134 ? 214.895 258.422 68.006 1.00 66.38  ? 134 ASP A N   1 
ATOM 1044 C CA  . ASP A 1 134 ? 216.125 259.165 67.797 1.00 69.15  ? 134 ASP A CA  1 
ATOM 1045 C C   . ASP A 1 134 ? 217.350 258.384 68.272 1.00 65.38  ? 134 ASP A C   1 
ATOM 1046 O O   . ASP A 1 134 ? 218.413 258.488 67.668 1.00 65.95  ? 134 ASP A O   1 
ATOM 1047 C CB  . ASP A 1 134 ? 216.114 260.496 68.530 1.00 73.15  ? 134 ASP A CB  1 
ATOM 1048 C CG  . ASP A 1 134 ? 215.226 261.590 67.939 1.00 80.44  ? 134 ASP A CG  1 
ATOM 1049 O OD1 . ASP A 1 134 ? 214.661 261.369 66.826 1.00 78.36  ? 134 ASP A OD1 1 
ATOM 1050 O OD2 . ASP A 1 134 ? 215.094 262.665 68.604 1.00 82.62  ? 134 ASP A OD2 1 
ATOM 1051 N N   . THR A 1 135 ? 217.205 257.653 69.372 1.00 64.25  ? 135 THR A N   1 
ATOM 1052 C CA  . THR A 1 135 ? 218.293 256.888 69.950 1.00 64.41  ? 135 THR A CA  1 
ATOM 1053 C C   . THR A 1 135 ? 218.634 255.687 69.079 1.00 64.75  ? 135 THR A C   1 
ATOM 1054 O O   . THR A 1 135 ? 219.814 255.399 68.927 1.00 66.67  ? 135 THR A O   1 
ATOM 1055 C CB  . THR A 1 135 ? 217.916 256.467 71.369 1.00 67.80  ? 135 THR A CB  1 
ATOM 1056 O OG1 . THR A 1 135 ? 217.727 257.702 72.057 1.00 71.06  ? 135 THR A OG1 1 
ATOM 1057 C CG2 . THR A 1 135 ? 218.997 255.682 72.089 1.00 67.36  ? 135 THR A CG2 1 
ATOM 1058 N N   . VAL A 1 136 ? 217.634 254.962 68.581 1.00 62.45  ? 136 VAL A N   1 
ATOM 1059 C CA  . VAL A 1 136 ? 217.864 253.838 67.695 1.00 59.65  ? 136 VAL A CA  1 
ATOM 1060 C C   . VAL A 1 136 ? 218.495 254.340 66.406 1.00 62.62  ? 136 VAL A C   1 
ATOM 1061 O O   . VAL A 1 136 ? 219.330 253.684 65.813 1.00 64.43  ? 136 VAL A O   1 
ATOM 1062 C CB  . VAL A 1 136 ? 216.557 253.083 67.413 1.00 60.57  ? 136 VAL A CB  1 
ATOM 1063 C CG1 . VAL A 1 136 ? 216.723 252.025 66.332 1.00 61.94  ? 136 VAL A CG1 1 
ATOM 1064 C CG2 . VAL A 1 136 ? 215.994 252.473 68.693 1.00 59.28  ? 136 VAL A CG2 1 
ATOM 1065 N N   . SER A 1 137 ? 218.068 255.510 65.963 1.00 65.90  ? 137 SER A N   1 
ATOM 1066 C CA  . SER A 1 137 ? 218.578 256.087 64.737 1.00 65.67  ? 137 SER A CA  1 
ATOM 1067 C C   . SER A 1 137 ? 220.083 256.321 64.835 1.00 65.07  ? 137 SER A C   1 
ATOM 1068 O O   . SER A 1 137 ? 220.788 256.073 63.872 1.00 67.55  ? 137 SER A O   1 
ATOM 1069 C CB  . SER A 1 137 ? 217.829 257.345 64.426 1.00 67.37  ? 137 SER A CB  1 
ATOM 1070 O OG  . SER A 1 137 ? 218.398 258.035 63.320 1.00 73.71  ? 137 SER A OG  1 
ATOM 1071 N N   . SER A 1 138 ? 220.574 256.830 65.970 1.00 67.55  ? 138 SER A N   1 
ATOM 1072 C CA  . SER A 1 138 ? 221.992 257.143 66.115 1.00 67.22  ? 138 SER A CA  1 
ATOM 1073 C C   . SER A 1 138 ? 222.768 255.868 66.435 1.00 67.08  ? 138 SER A C   1 
ATOM 1074 O O   . SER A 1 138 ? 223.886 255.691 65.973 1.00 67.75  ? 138 SER A O   1 
ATOM 1075 C CB  . SER A 1 138 ? 222.250 258.196 67.156 1.00 65.54  ? 138 SER A CB  1 
ATOM 1076 O OG  . SER A 1 138 ? 221.741 257.760 68.406 1.00 67.32  ? 138 SER A OG  1 
ATOM 1077 N N   . THR A 1 139 ? 222.172 254.969 67.214 1.00 64.58  ? 139 THR A N   1 
ATOM 1078 C CA  . THR A 1 139 ? 222.830 253.713 67.515 1.00 62.51  ? 139 THR A CA  1 
ATOM 1079 C C   . THR A 1 139 ? 223.179 252.971 66.236 1.00 66.16  ? 139 THR A C   1 
ATOM 1080 O O   . THR A 1 139 ? 224.293 252.470 66.116 1.00 70.59  ? 139 THR A O   1 
ATOM 1081 C CB  . THR A 1 139 ? 221.954 252.830 68.390 1.00 64.26  ? 139 THR A CB  1 
ATOM 1082 O OG1 . THR A 1 139 ? 221.797 253.531 69.617 1.00 67.07  ? 139 THR A OG1 1 
ATOM 1083 C CG2 . THR A 1 139 ? 222.615 251.515 68.728 1.00 67.57  ? 139 THR A CG2 1 
ATOM 1084 N N   . THR A 1 140 ? 222.244 252.913 65.290 1.00 66.00  ? 140 THR A N   1 
ATOM 1085 C CA  . THR A 1 140 ? 222.444 252.204 64.048 1.00 60.16  ? 140 THR A CA  1 
ATOM 1086 C C   . THR A 1 140 ? 222.827 253.141 62.908 1.00 62.46  ? 140 THR A C   1 
ATOM 1087 O O   . THR A 1 140 ? 222.590 252.804 61.758 1.00 69.74  ? 140 THR A O   1 
ATOM 1088 C CB  . THR A 1 140 ? 221.163 251.447 63.740 1.00 68.36  ? 140 THR A CB  1 
ATOM 1089 O OG1 . THR A 1 140 ? 220.162 252.427 63.467 1.00 69.74  ? 140 THR A OG1 1 
ATOM 1090 C CG2 . THR A 1 140 ? 220.744 250.544 64.886 1.00 70.01  ? 140 THR A CG2 1 
ATOM 1091 N N   . THR A 1 141 ? 223.563 254.215 63.190 1.00 65.64  ? 141 THR A N   1 
ATOM 1092 C CA  . THR A 1 141 ? 223.821 255.224 62.172 1.00 67.14  ? 141 THR A CA  1 
ATOM 1093 C C   . THR A 1 141 ? 224.765 254.736 61.065 1.00 67.08  ? 141 THR A C   1 
ATOM 1094 O O   . THR A 1 141 ? 224.658 255.201 59.937 1.00 73.01  ? 141 THR A O   1 
ATOM 1095 C CB  . THR A 1 141 ? 224.330 256.514 62.826 1.00 69.58  ? 141 THR A CB  1 
ATOM 1096 O OG1 . THR A 1 141 ? 224.080 257.590 61.925 1.00 72.30  ? 141 THR A OG1 1 
ATOM 1097 C CG2 . THR A 1 141 ? 225.819 256.524 63.110 1.00 69.95  ? 141 THR A CG2 1 
ATOM 1098 N N   . LEU A 1 142 ? 225.695 253.825 61.348 1.00 70.19  ? 142 LEU A N   1 
ATOM 1099 C CA  . LEU A 1 142 ? 226.686 253.437 60.349 1.00 71.68  ? 142 LEU A CA  1 
ATOM 1100 C C   . LEU A 1 142 ? 226.124 252.354 59.431 1.00 71.34  ? 142 LEU A C   1 
ATOM 1101 O O   . LEU A 1 142 ? 226.642 252.137 58.335 1.00 72.00  ? 142 LEU A O   1 
ATOM 1102 C CB  . LEU A 1 142 ? 227.984 252.987 61.015 1.00 70.49  ? 142 LEU A CB  1 
ATOM 1103 C CG  . LEU A 1 142 ? 228.780 254.104 61.691 1.00 72.59  ? 142 LEU A CG  1 
ATOM 1104 C CD1 . LEU A 1 142 ? 229.826 253.539 62.636 1.00 78.59  ? 142 LEU A CD1 1 
ATOM 1105 C CD2 . LEU A 1 142 ? 229.416 254.990 60.644 1.00 72.84  ? 142 LEU A CD2 1 
ATOM 1106 N N   . THR A 1 143 ? 225.036 251.718 59.857 1.00 71.48  ? 143 THR A N   1 
ATOM 1107 C CA  . THR A 1 143 ? 224.310 250.745 59.029 1.00 70.04  ? 143 THR A CA  1 
ATOM 1108 C C   . THR A 1 143 ? 223.389 251.467 58.045 1.00 73.95  ? 143 THR A C   1 
ATOM 1109 O O   . THR A 1 143 ? 222.997 250.809 57.085 1.00 76.56  ? 143 THR A O   1 
ATOM 1110 C CB  . THR A 1 143 ? 223.560 249.795 59.952 1.00 70.73  ? 143 THR A CB  1 
ATOM 1111 O OG1 . THR A 1 143 ? 224.571 249.189 60.745 1.00 74.90  ? 143 THR A OG1 1 
ATOM 1112 C CG2 . THR A 1 143 ? 222.808 248.716 59.199 1.00 77.91  ? 143 THR A CG2 1 
ATOM 1113 N N   . THR A 1 144 ? 223.051 252.751 58.230 1.00 72.30  ? 144 THR A N   1 
ATOM 1114 C CA  . THR A 1 144 ? 222.280 253.466 57.219 1.00 74.53  ? 144 THR A CA  1 
ATOM 1115 C C   . THR A 1 144 ? 222.933 254.804 56.906 1.00 78.08  ? 144 THR A C   1 
ATOM 1116 O O   . THR A 1 144 ? 222.460 255.840 57.359 1.00 79.70  ? 144 THR A O   1 
ATOM 1117 C CB  . THR A 1 144 ? 220.836 253.723 57.655 1.00 76.40  ? 144 THR A CB  1 
ATOM 1118 O OG1 . THR A 1 144 ? 220.974 254.396 58.901 1.00 79.66  ? 144 THR A OG1 1 
ATOM 1119 C CG2 . THR A 1 144 ? 220.003 252.478 57.889 1.00 77.08  ? 144 THR A CG2 1 
ATOM 1120 N N   . PRO A 1 145 ? 224.013 254.858 56.104 1.00 78.13  ? 145 PRO A N   1 
ATOM 1121 C CA  . PRO A 1 145 ? 224.560 256.147 55.692 1.00 80.53  ? 145 PRO A CA  1 
ATOM 1122 C C   . PRO A 1 145 ? 223.555 256.945 54.874 1.00 84.43  ? 145 PRO A C   1 
ATOM 1123 O O   . PRO A 1 145 ? 222.858 256.386 54.036 1.00 85.14  ? 145 PRO A O   1 
ATOM 1124 C CB  . PRO A 1 145 ? 225.782 255.784 54.872 1.00 81.05  ? 145 PRO A CB  1 
ATOM 1125 C CG  . PRO A 1 145 ? 226.103 254.392 55.342 1.00 81.44  ? 145 PRO A CG  1 
ATOM 1126 C CD  . PRO A 1 145 ? 224.779 253.718 55.591 1.00 77.53  ? 145 PRO A CD  1 
ATOM 1127 N N   . GLN A 1 146 ? 223.534 258.264 55.101 1.00 86.38  ? 146 GLN A N   1 
ATOM 1128 C CA  . GLN A 1 146 ? 222.627 259.158 54.401 1.00 89.46  ? 146 GLN A CA  1 
ATOM 1129 C C   . GLN A 1 146 ? 222.815 259.026 52.893 1.00 89.47  ? 146 GLN A C   1 
ATOM 1130 O O   . GLN A 1 146 ? 221.838 258.866 52.177 1.00 92.17  ? 146 GLN A O   1 
ATOM 1131 C CB  . GLN A 1 146 ? 222.827 260.617 54.822 1.00 91.00  ? 146 GLN A CB  1 
ATOM 1132 C CG  . GLN A 1 146 ? 221.663 261.531 54.458 1.00 91.37  ? 146 GLN A CG  1 
ATOM 1133 C CD  . GLN A 1 146 ? 220.332 260.959 54.909 1.00 95.48  ? 146 GLN A CD  1 
ATOM 1134 O OE1 . GLN A 1 146 ? 220.144 260.627 56.090 1.00 95.71  ? 146 GLN A OE1 1 
ATOM 1135 N NE2 . GLN A 1 146 ? 219.407 260.784 53.971 1.00 95.36  ? 146 GLN A NE2 1 
ATOM 1136 N N   . ASN A 1 147 ? 224.063 259.096 52.420 1.00 90.17  ? 147 ASN A N   1 
ATOM 1137 C CA  . ASN A 1 147 ? 224.348 259.163 50.996 1.00 92.44  ? 147 ASN A CA  1 
ATOM 1138 C C   . ASN A 1 147 ? 223.874 257.896 50.283 1.00 90.72  ? 147 ASN A C   1 
ATOM 1139 O O   . ASN A 1 147 ? 223.469 257.965 49.128 1.00 95.23  ? 147 ASN A O   1 
ATOM 1140 C CB  . ASN A 1 147 ? 225.821 259.487 50.744 1.00 93.55  ? 147 ASN A CB  1 
ATOM 1141 C CG  . ASN A 1 147 ? 226.762 258.485 51.379 1.00 98.12  ? 147 ASN A CG  1 
ATOM 1142 O OD1 . ASN A 1 147 ? 226.915 257.361 50.875 1.00 95.40  ? 147 ASN A OD1 1 
ATOM 1143 N ND2 . ASN A 1 147 ? 227.418 258.864 52.471 1.00 99.96  ? 147 ASN A ND2 1 
ATOM 1144 N N   . GLN A 1 148 ? 223.894 256.752 50.962 1.00 89.46  ? 148 GLN A N   1 
ATOM 1145 C CA  . GLN A 1 148 ? 223.483 255.509 50.334 1.00 90.56  ? 148 GLN A CA  1 
ATOM 1146 C C   . GLN A 1 148 ? 221.968 255.462 50.167 1.00 90.85  ? 148 GLN A C   1 
ATOM 1147 O O   . GLN A 1 148 ? 221.483 254.869 49.209 1.00 92.86  ? 148 GLN A O   1 
ATOM 1148 C CB  . GLN A 1 148 ? 223.910 254.279 51.137 1.00 90.78  ? 148 GLN A CB  1 
ATOM 1149 C CG  . GLN A 1 148 ? 225.415 254.028 51.168 1.00 89.78  ? 148 GLN A CG  1 
ATOM 1150 C CD  . GLN A 1 148 ? 225.767 252.708 51.816 1.00 87.21  ? 148 GLN A CD  1 
ATOM 1151 O OE1 . GLN A 1 148 ? 225.017 251.728 51.734 1.00 89.18  ? 148 GLN A OE1 1 
ATOM 1152 N NE2 . GLN A 1 148 ? 226.933 252.656 52.447 1.00 86.76  ? 148 GLN A NE2 1 
ATOM 1153 N N   . VAL A 1 149 ? 221.237 256.043 51.126 1.00 90.45  ? 149 VAL A N   1 
ATOM 1154 C CA  . VAL A 1 149 ? 219.782 256.055 51.105 1.00 89.57  ? 149 VAL A CA  1 
ATOM 1155 C C   . VAL A 1 149 ? 219.317 256.991 49.992 1.00 91.44  ? 149 VAL A C   1 
ATOM 1156 O O   . VAL A 1 149 ? 218.410 256.649 49.246 1.00 93.98  ? 149 VAL A O   1 
ATOM 1157 C CB  . VAL A 1 149 ? 219.189 256.462 52.466 1.00 88.00  ? 149 VAL A CB  1 
ATOM 1158 C CG1 . VAL A 1 149 ? 217.674 256.577 52.418 1.00 91.94  ? 149 VAL A CG1 1 
ATOM 1159 C CG2 . VAL A 1 149 ? 219.580 255.496 53.568 1.00 88.69  ? 149 VAL A CG2 1 
ATOM 1160 N N   . ASP A 1 150 ? 219.958 258.160 49.888 1.00 92.74  ? 150 ASP A N   1 
ATOM 1161 C CA  . ASP A 1 150 ? 219.676 259.145 48.857 1.00 93.57  ? 150 ASP A CA  1 
ATOM 1162 C C   . ASP A 1 150 ? 219.898 258.561 47.459 1.00 96.15  ? 150 ASP A C   1 
ATOM 1163 O O   . ASP A 1 150 ? 219.067 258.768 46.576 1.00 100.88 ? 150 ASP A O   1 
ATOM 1164 C CB  . ASP A 1 150 ? 220.511 260.402 49.063 1.00 95.96  ? 150 ASP A CB  1 
ATOM 1165 C CG  . ASP A 1 150 ? 220.270 261.179 50.359 1.00 98.93  ? 150 ASP A CG  1 
ATOM 1166 O OD1 . ASP A 1 150 ? 219.271 260.876 51.068 1.00 100.35 ? 150 ASP A OD1 1 
ATOM 1167 O OD2 . ASP A 1 150 ? 221.090 262.090 50.667 1.00 101.81 ? 150 ASP A OD2 1 
ATOM 1168 N N   . MET A 1 151 ? 221.007 257.839 47.248 1.00 94.75  ? 151 MET A N   1 
ATOM 1169 C CA  . MET A 1 151 ? 221.299 257.247 45.950 1.00 95.58  ? 151 MET A CA  1 
ATOM 1170 C C   . MET A 1 151 ? 220.304 256.140 45.590 1.00 96.61  ? 151 MET A C   1 
ATOM 1171 O O   . MET A 1 151 ? 219.927 256.031 44.427 1.00 102.48 ? 151 MET A O   1 
ATOM 1172 C CB  . MET A 1 151 ? 222.733 256.715 45.907 1.00 98.85  ? 151 MET A CB  1 
ATOM 1173 C CG  . MET A 1 151 ? 223.759 257.833 45.824 1.00 102.77 ? 151 MET A CG  1 
ATOM 1174 S SD  . MET A 1 151 ? 225.472 257.254 45.808 1.00 115.17 ? 151 MET A SD  1 
ATOM 1175 C CE  . MET A 1 151 ? 225.560 256.490 44.179 1.00 113.82 ? 151 MET A CE  1 
ATOM 1176 N N   . LEU A 1 152 ? 219.876 255.325 46.551 1.00 93.53  ? 152 LEU A N   1 
ATOM 1177 C CA  . LEU A 1 152 ? 218.883 254.295 46.280 1.00 94.05  ? 152 LEU A CA  1 
ATOM 1178 C C   . LEU A 1 152 ? 217.538 254.931 45.926 1.00 98.45  ? 152 LEU A C   1 
ATOM 1179 O O   . LEU A 1 152 ? 216.869 254.454 45.016 1.00 101.88 ? 152 LEU A O   1 
ATOM 1180 C CB  . LEU A 1 152 ? 218.770 253.326 47.457 1.00 92.20  ? 152 LEU A CB  1 
ATOM 1181 C CG  . LEU A 1 152 ? 217.721 252.219 47.323 1.00 90.19  ? 152 LEU A CG  1 
ATOM 1182 C CD1 . LEU A 1 152 ? 217.956 251.323 46.123 1.00 92.29  ? 152 LEU A CD1 1 
ATOM 1183 C CD2 . LEU A 1 152 ? 217.682 251.373 48.576 1.00 89.42  ? 152 LEU A CD2 1 
ATOM 1184 N N   . LEU A 1 153 ? 217.143 256.011 46.613 1.00 98.71  ? 153 LEU A N   1 
ATOM 1185 C CA  . LEU A 1 153 ? 215.926 256.736 46.265 1.00 99.67  ? 153 LEU A CA  1 
ATOM 1186 C C   . LEU A 1 153 ? 216.030 257.339 44.867 1.00 104.32 ? 153 LEU A C   1 
ATOM 1187 O O   . LEU A 1 153 ? 215.066 257.266 44.118 1.00 107.49 ? 153 LEU A O   1 
ATOM 1188 C CB  . LEU A 1 153 ? 215.589 257.810 47.298 1.00 102.77 ? 153 LEU A CB  1 
ATOM 1189 C CG  . LEU A 1 153 ? 214.965 257.305 48.603 1.00 97.94  ? 153 LEU A CG  1 
ATOM 1190 C CD1 . LEU A 1 153 ? 214.836 258.449 49.591 1.00 99.27  ? 153 LEU A CD1 1 
ATOM 1191 C CD2 . LEU A 1 153 ? 213.603 256.660 48.404 1.00 95.84  ? 153 LEU A CD2 1 
ATOM 1192 N N   . GLN A 1 154 ? 217.175 257.921 44.506 1.00 105.55 ? 154 GLN A N   1 
ATOM 1193 C CA  . GLN A 1 154 ? 217.346 258.486 43.176 1.00 109.03 ? 154 GLN A CA  1 
ATOM 1194 C C   . GLN A 1 154 ? 217.236 257.400 42.099 1.00 108.44 ? 154 GLN A C   1 
ATOM 1195 O O   . GLN A 1 154 ? 216.558 257.602 41.102 1.00 111.35 ? 154 GLN A O   1 
ATOM 1196 C CB  . GLN A 1 154 ? 218.667 259.246 43.081 1.00 109.66 ? 154 GLN A CB  1 
ATOM 1197 C CG  . GLN A 1 154 ? 218.771 260.095 41.818 1.00 112.45 ? 154 GLN A CG  1 
ATOM 1198 C CD  . GLN A 1 154 ? 217.771 261.233 41.813 1.00 118.10 ? 154 GLN A CD  1 
ATOM 1199 O OE1 . GLN A 1 154 ? 217.835 262.130 42.660 1.00 125.43 ? 154 GLN A OE1 1 
ATOM 1200 N NE2 . GLN A 1 154 ? 216.825 261.215 40.883 1.00 117.28 ? 154 GLN A NE2 1 
ATOM 1201 N N   . GLU A 1 155 ? 217.901 256.258 42.295 1.00 107.53 ? 155 GLU A N   1 
ATOM 1202 C CA  . GLU A 1 155 ? 217.828 255.120 41.387 1.00 108.40 ? 155 GLU A CA  1 
ATOM 1203 C C   . GLU A 1 155 ? 216.379 254.663 41.195 1.00 108.78 ? 155 GLU A C   1 
ATOM 1204 O O   . GLU A 1 155 ? 215.956 254.428 40.067 1.00 112.67 ? 155 GLU A O   1 
ATOM 1205 C CB  . GLU A 1 155 ? 218.718 254.002 41.943 1.00 110.86 ? 155 GLU A CB  1 
ATOM 1206 C CG  . GLU A 1 155 ? 218.696 252.700 41.142 1.00 113.43 ? 155 GLU A CG  1 
ATOM 1207 C CD  . GLU A 1 155 ? 219.499 251.566 41.770 1.00 118.72 ? 155 GLU A CD  1 
ATOM 1208 O OE1 . GLU A 1 155 ? 220.629 251.833 42.260 1.00 120.21 ? 155 GLU A OE1 1 
ATOM 1209 O OE2 . GLU A 1 155 ? 219.002 250.410 41.755 1.00 116.73 ? 155 GLU A OE2 1 
ATOM 1210 N N   . MET A 1 156 ? 215.623 254.515 42.286 1.00 108.51 ? 156 MET A N   1 
ATOM 1211 C CA  . MET A 1 156 ? 214.244 254.049 42.219 1.00 107.33 ? 156 MET A CA  1 
ATOM 1212 C C   . MET A 1 156 ? 213.334 255.088 41.556 1.00 109.72 ? 156 MET A C   1 
ATOM 1213 O O   . MET A 1 156 ? 212.392 254.714 40.867 1.00 113.38 ? 156 MET A O   1 
ATOM 1214 C CB  . MET A 1 156 ? 213.735 253.714 43.625 1.00 107.69 ? 156 MET A CB  1 
ATOM 1215 C CG  . MET A 1 156 ? 214.419 252.526 44.274 1.00 104.67 ? 156 MET A CG  1 
ATOM 1216 S SD  . MET A 1 156 ? 213.986 250.938 43.547 1.00 105.78 ? 156 MET A SD  1 
ATOM 1217 C CE  . MET A 1 156 ? 215.425 250.684 42.494 1.00 111.11 ? 156 MET A CE  1 
ATOM 1218 N N   . ALA A 1 157 ? 213.600 256.382 41.770 1.00 110.41 ? 157 ALA A N   1 
ATOM 1219 C CA  . ALA A 1 157 ? 212.860 257.461 41.128 1.00 109.78 ? 157 ALA A CA  1 
ATOM 1220 C C   . ALA A 1 157 ? 213.134 257.497 39.624 1.00 112.42 ? 157 ALA A C   1 
ATOM 1221 O O   . ALA A 1 157 ? 212.197 257.613 38.842 1.00 117.53 ? 157 ALA A O   1 
ATOM 1222 C CB  . ALA A 1 157 ? 213.205 258.781 41.788 1.00 111.67 ? 157 ALA A CB  1 
ATOM 1223 N N   . ASP A 1 158 ? 214.402 257.343 39.232 1.00 112.27 ? 158 ASP A N   1 
ATOM 1224 C CA  . ASP A 1 158 ? 214.800 257.358 37.797 1.00 113.82 ? 158 ASP A CA  1 
ATOM 1225 C C   . ASP A 1 158 ? 214.124 256.197 37.064 1.00 114.91 ? 158 ASP A C   1 
ATOM 1226 O O   . ASP A 1 158 ? 213.666 256.411 35.923 1.00 116.48 ? 158 ASP A O   1 
ATOM 1227 C CB  . ASP A 1 158 ? 216.310 257.279 37.664 1.00 114.63 ? 158 ASP A CB  1 
ATOM 1228 C CG  . ASP A 1 158 ? 217.075 258.469 38.222 1.00 116.57 ? 158 ASP A CG  1 
ATOM 1229 O OD1 . ASP A 1 158 ? 216.619 259.611 38.002 1.00 114.82 ? 158 ASP A OD1 1 
ATOM 1230 O OD2 . ASP A 1 158 ? 218.117 258.243 38.870 1.00 117.73 ? 158 ASP A OD2 1 
ATOM 1231 N N   . GLU A 1 159 ? 214.099 255.011 37.676 1.00 114.18 ? 159 GLU A N   1 
ATOM 1232 C CA  . GLU A 1 159 ? 213.465 253.839 37.079 1.00 117.35 ? 159 GLU A CA  1 
ATOM 1233 C C   . GLU A 1 159 ? 211.944 253.999 36.971 1.00 116.31 ? 159 GLU A C   1 
ATOM 1234 O O   . GLU A 1 159 ? 211.335 253.413 36.078 1.00 117.61 ? 159 GLU A O   1 
ATOM 1235 C CB  . GLU A 1 159 ? 213.813 252.570 37.869 1.00 119.18 ? 159 GLU A CB  1 
ATOM 1236 C CG  . GLU A 1 159 ? 215.262 252.095 37.716 1.00 121.20 ? 159 GLU A CG  1 
ATOM 1237 C CD  . GLU A 1 159 ? 215.613 251.411 36.391 1.00 126.57 ? 159 GLU A CD  1 
ATOM 1238 O OE1 . GLU A 1 159 ? 214.833 251.513 35.409 1.00 125.32 ? 159 GLU A OE1 1 
ATOM 1239 O OE2 . GLU A 1 159 ? 216.682 250.749 36.339 1.00 126.24 ? 159 GLU A OE2 1 
ATOM 1240 N N   . ALA A 1 160 ? 211.328 254.770 37.879 1.00 116.05 ? 160 ALA A N   1 
ATOM 1241 C CA  . ALA A 1 160 ? 209.896 255.056 37.851 1.00 116.78 ? 160 ALA A CA  1 
ATOM 1242 C C   . ALA A 1 160 ? 209.537 256.212 36.908 1.00 118.21 ? 160 ALA A C   1 
ATOM 1243 O O   . ALA A 1 160 ? 208.357 256.457 36.671 1.00 119.06 ? 160 ALA A O   1 
ATOM 1244 C CB  . ALA A 1 160 ? 209.431 255.368 39.256 1.00 116.61 ? 160 ALA A CB  1 
ATOM 1245 N N   . GLY A 1 161 ? 210.543 256.943 36.407 1.00 118.70 ? 161 GLY A N   1 
ATOM 1246 C CA  . GLY A 1 161 ? 210.340 258.128 35.582 1.00 120.27 ? 161 GLY A CA  1 
ATOM 1247 C C   . GLY A 1 161 ? 209.923 259.367 36.379 1.00 123.36 ? 161 GLY A C   1 
ATOM 1248 O O   . GLY A 1 161 ? 209.483 260.351 35.784 1.00 126.05 ? 161 GLY A O   1 
ATOM 1249 N N   . LEU A 1 162 ? 210.078 259.331 37.709 1.00 123.19 ? 162 LEU A N   1 
ATOM 1250 C CA  . LEU A 1 162 ? 209.724 260.446 38.579 1.00 125.54 ? 162 LEU A CA  1 
ATOM 1251 C C   . LEU A 1 162 ? 210.794 261.542 38.510 1.00 129.51 ? 162 LEU A C   1 
ATOM 1252 O O   . LEU A 1 162 ? 211.956 261.305 38.837 1.00 127.79 ? 162 LEU A O   1 
ATOM 1253 C CB  . LEU A 1 162 ? 209.543 259.922 40.003 1.00 125.11 ? 162 LEU A CB  1 
ATOM 1254 C CG  . LEU A 1 162 ? 209.321 260.982 41.086 1.00 127.65 ? 162 LEU A CG  1 
ATOM 1255 C CD1 . LEU A 1 162 ? 208.037 261.775 40.876 1.00 129.16 ? 162 LEU A CD1 1 
ATOM 1256 C CD2 . LEU A 1 162 ? 209.312 260.318 42.441 1.00 127.82 ? 162 LEU A CD2 1 
ATOM 1257 N N   . ASP A 1 163 ? 210.382 262.755 38.108 1.00 130.58 ? 163 ASP A N   1 
ATOM 1258 C CA  . ASP A 1 163 ? 211.279 263.896 37.952 1.00 134.07 ? 163 ASP A CA  1 
ATOM 1259 C C   . ASP A 1 163 ? 211.481 264.603 39.300 1.00 134.96 ? 163 ASP A C   1 
ATOM 1260 O O   . ASP A 1 163 ? 210.851 265.626 39.576 1.00 136.39 ? 163 ASP A O   1 
ATOM 1261 C CB  . ASP A 1 163 ? 210.773 264.829 36.856 1.00 136.06 ? 163 ASP A CB  1 
ATOM 1262 C CG  . ASP A 1 163 ? 211.698 265.987 36.491 1.00 137.31 ? 163 ASP A CG  1 
ATOM 1263 O OD1 . ASP A 1 163 ? 212.858 265.995 36.973 1.00 136.69 ? 163 ASP A OD1 1 
ATOM 1264 O OD2 . ASP A 1 163 ? 211.251 266.880 35.729 1.00 137.85 ? 163 ASP A OD2 1 
ATOM 1265 N N   . LEU A 1 164 ? 212.375 264.048 40.136 1.00 135.05 ? 164 LEU A N   1 
ATOM 1266 C CA  . LEU A 1 164 ? 212.690 264.585 41.457 1.00 137.31 ? 164 LEU A CA  1 
ATOM 1267 C C   . LEU A 1 164 ? 214.156 264.289 41.809 1.00 137.42 ? 164 LEU A C   1 
ATOM 1268 O O   . LEU A 1 164 ? 214.706 263.281 41.361 1.00 131.56 ? 164 LEU A O   1 
ATOM 1269 C CB  . LEU A 1 164 ? 211.714 263.971 42.468 1.00 136.83 ? 164 LEU A CB  1 
ATOM 1270 C CG  . LEU A 1 164 ? 211.785 264.484 43.914 1.00 139.14 ? 164 LEU A CG  1 
ATOM 1271 C CD1 . LEU A 1 164 ? 211.507 265.985 44.026 1.00 142.09 ? 164 LEU A CD1 1 
ATOM 1272 C CD2 . LEU A 1 164 ? 210.791 263.724 44.796 1.00 138.00 ? 164 LEU A CD2 1 
ATOM 1273 N N   . ASN A 1 165 ? 214.786 265.169 42.612 1.00 137.29 ? 165 ASN A N   1 
ATOM 1274 C CA  . ASN A 1 165 ? 216.156 264.982 43.088 1.00 135.42 ? 165 ASN A CA  1 
ATOM 1275 C C   . ASN A 1 165 ? 216.141 264.711 44.600 1.00 133.96 ? 165 ASN A C   1 
ATOM 1276 O O   . ASN A 1 165 ? 215.635 265.522 45.375 1.00 139.19 ? 165 ASN A O   1 
ATOM 1277 C CB  . ASN A 1 165 ? 217.035 266.167 42.679 1.00 136.28 ? 165 ASN A CB  1 
ATOM 1278 C CG  . ASN A 1 165 ? 218.508 266.009 43.011 1.00 136.30 ? 165 ASN A CG  1 
ATOM 1279 O OD1 . ASN A 1 165 ? 219.177 267.000 43.326 1.00 140.72 ? 165 ASN A OD1 1 
ATOM 1280 N ND2 . ASN A 1 165 ? 219.070 264.811 42.900 1.00 134.05 ? 165 ASN A ND2 1 
ATOM 1281 N N   . MET A 1 166 ? 216.723 263.571 45.017 1.00 134.06 ? 166 MET A N   1 
ATOM 1282 C CA  . MET A 1 166 ? 216.497 263.000 46.347 1.00 134.11 ? 166 MET A CA  1 
ATOM 1283 C C   . MET A 1 166 ? 217.563 263.397 47.385 1.00 137.28 ? 166 MET A C   1 
ATOM 1284 O O   . MET A 1 166 ? 217.332 263.214 48.581 1.00 135.39 ? 166 MET A O   1 
ATOM 1285 C CB  . MET A 1 166 ? 216.399 261.471 46.222 1.00 125.02 ? 166 MET A CB  1 
ATOM 1286 C CG  . MET A 1 166 ? 215.209 261.008 45.375 1.00 121.85 ? 166 MET A CG  1 
ATOM 1287 S SD  . MET A 1 166 ? 213.606 261.373 46.125 1.00 132.60 ? 166 MET A SD  1 
ATOM 1288 C CE  . MET A 1 166 ? 212.524 260.302 45.169 1.00 129.15 ? 166 MET A CE  1 
ATOM 1289 N N   . GLU A 1 167 ? 218.710 263.952 46.949 1.00 139.14 ? 167 GLU A N   1 
ATOM 1290 C CA  . GLU A 1 167 ? 219.773 264.412 47.845 1.00 139.43 ? 167 GLU A CA  1 
ATOM 1291 C C   . GLU A 1 167 ? 219.443 265.783 48.460 1.00 144.08 ? 167 GLU A C   1 
ATOM 1292 O O   . GLU A 1 167 ? 219.829 266.050 49.600 1.00 144.29 ? 167 GLU A O   1 
ATOM 1293 C CB  . GLU A 1 167 ? 221.098 264.411 47.072 1.00 144.53 ? 167 GLU A CB  1 
ATOM 1294 C CG  . GLU A 1 167 ? 222.315 264.890 47.866 1.00 145.38 ? 167 GLU A CG  1 
ATOM 1295 C CD  . GLU A 1 167 ? 223.658 264.746 47.151 1.00 148.64 ? 167 GLU A CD  1 
ATOM 1296 O OE1 . GLU A 1 167 ? 223.719 264.096 46.077 1.00 149.16 ? 167 GLU A OE1 1 
ATOM 1297 O OE2 . GLU A 1 167 ? 224.658 265.301 47.670 1.00 149.20 ? 167 GLU A OE2 1 
ATOM 1298 N N   . LEU A 1 168 ? 218.737 266.649 47.711 1.00 144.77 ? 168 LEU A N   1 
ATOM 1299 C CA  . LEU A 1 168 ? 218.339 267.977 48.176 1.00 147.36 ? 168 LEU A CA  1 
ATOM 1300 C C   . LEU A 1 168 ? 217.174 267.899 49.169 1.00 149.12 ? 168 LEU A C   1 
ATOM 1301 O O   . LEU A 1 168 ? 216.393 266.945 49.141 1.00 147.93 ? 168 LEU A O   1 
ATOM 1302 C CB  . LEU A 1 168 ? 217.951 268.844 46.974 1.00 147.61 ? 168 LEU A CB  1 
ATOM 1303 C CG  . LEU A 1 168 ? 219.070 269.191 45.983 1.00 147.04 ? 168 LEU A CG  1 
ATOM 1304 C CD1 . LEU A 1 168 ? 218.512 269.954 44.786 1.00 146.36 ? 168 LEU A CD1 1 
ATOM 1305 C CD2 . LEU A 1 168 ? 220.174 269.997 46.626 1.00 146.74 ? 168 LEU A CD2 1 
ATOM 1306 N N   . PRO A 1 169 ? 216.986 268.921 50.047 1.00 150.12 ? 169 PRO A N   1 
ATOM 1307 C CA  . PRO A 1 169 ? 215.775 269.025 50.863 1.00 150.81 ? 169 PRO A CA  1 
ATOM 1308 C C   . PRO A 1 169 ? 214.554 269.351 50.006 1.00 151.97 ? 169 PRO A C   1 
ATOM 1309 O O   . PRO A 1 169 ? 214.663 270.097 49.029 1.00 151.33 ? 169 PRO A O   1 
ATOM 1310 C CB  . PRO A 1 169 ? 216.100 270.148 51.864 1.00 150.60 ? 169 PRO A CB  1 
ATOM 1311 C CG  . PRO A 1 169 ? 217.088 271.024 51.134 1.00 150.35 ? 169 PRO A CG  1 
ATOM 1312 C CD  . PRO A 1 169 ? 217.902 270.049 50.293 1.00 149.68 ? 169 PRO A CD  1 
ATOM 1313 N N   . GLN A 1 170 ? 213.397 268.784 50.393 1.00 152.55 ? 170 GLN A N   1 
ATOM 1314 C CA  . GLN A 1 170 ? 212.141 268.922 49.660 1.00 153.81 ? 170 GLN A CA  1 
ATOM 1315 C C   . GLN A 1 170 ? 210.991 269.261 50.637 1.00 155.70 ? 170 GLN A C   1 
ATOM 1316 O O   . GLN A 1 170 ? 210.955 268.643 51.734 1.00 155.50 ? 170 GLN A O   1 
ATOM 1317 C CB  . GLN A 1 170 ? 211.824 267.652 48.858 1.00 153.60 ? 170 GLN A CB  1 
ATOM 1318 C CG  . GLN A 1 170 ? 212.879 267.237 47.826 1.00 153.11 ? 170 GLN A CG  1 
ATOM 1319 C CD  . GLN A 1 170 ? 213.047 268.187 46.649 1.00 151.16 ? 170 GLN A CD  1 
ATOM 1320 O OE1 . GLN A 1 170 ? 212.290 269.150 46.465 1.00 153.42 ? 170 GLN A OE1 1 
ATOM 1321 N NE2 . GLN A 1 170 ? 214.036 267.919 45.803 1.00 149.61 ? 170 GLN A NE2 1 
ATOM 1322 N N   . ASP A 1 186 ? 200.576 277.411 54.402 1.00 130.89 ? 186 ASP A N   1 
ATOM 1323 C CA  . ASP A 1 186 ? 200.090 277.799 53.045 1.00 131.71 ? 186 ASP A CA  1 
ATOM 1324 C C   . ASP A 1 186 ? 200.199 279.319 52.898 1.00 131.59 ? 186 ASP A C   1 
ATOM 1325 O O   . ASP A 1 186 ? 200.795 279.980 53.750 1.00 130.91 ? 186 ASP A O   1 
ATOM 1326 C CB  . ASP A 1 186 ? 198.688 277.252 52.795 1.00 132.32 ? 186 ASP A CB  1 
ATOM 1327 C CG  . ASP A 1 186 ? 197.609 277.687 53.781 1.00 130.38 ? 186 ASP A CG  1 
ATOM 1328 O OD1 . ASP A 1 186 ? 197.957 278.332 54.802 1.00 128.67 ? 186 ASP A OD1 1 
ATOM 1329 O OD2 . ASP A 1 186 ? 196.421 277.380 53.519 1.00 129.18 ? 186 ASP A OD2 1 
ATOM 1330 N N   . GLU A 1 187 ? 199.621 279.862 51.814 1.00 131.77 ? 187 GLU A N   1 
ATOM 1331 C CA  . GLU A 1 187 ? 199.644 281.295 51.562 1.00 132.68 ? 187 GLU A CA  1 
ATOM 1332 C C   . GLU A 1 187 ? 198.916 282.041 52.684 1.00 131.20 ? 187 GLU A C   1 
ATOM 1333 O O   . GLU A 1 187 ? 199.380 283.100 53.106 1.00 131.25 ? 187 GLU A O   1 
ATOM 1334 C CB  . GLU A 1 187 ? 199.070 281.621 50.178 1.00 133.98 ? 187 GLU A CB  1 
ATOM 1335 C CG  . GLU A 1 187 ? 199.227 283.086 49.761 1.00 134.63 ? 187 GLU A CG  1 
ATOM 1336 C CD  . GLU A 1 187 ? 200.651 283.619 49.623 1.00 135.28 ? 187 GLU A CD  1 
ATOM 1337 O OE1 . GLU A 1 187 ? 201.603 282.817 49.452 1.00 136.43 ? 187 GLU A OE1 1 
ATOM 1338 O OE2 . GLU A 1 187 ? 200.809 284.861 49.710 1.00 135.63 ? 187 GLU A OE2 1 
ATOM 1339 N N   . LEU A 1 188 ? 197.792 281.488 53.168 1.00 129.67 ? 188 LEU A N   1 
ATOM 1340 C CA  . LEU A 1 188 ? 197.017 282.121 54.229 1.00 128.02 ? 188 LEU A CA  1 
ATOM 1341 C C   . LEU A 1 188 ? 197.879 282.294 55.482 1.00 128.76 ? 188 LEU A C   1 
ATOM 1342 O O   . LEU A 1 188 ? 197.850 283.354 56.107 1.00 127.07 ? 188 LEU A O   1 
ATOM 1343 C CB  . LEU A 1 188 ? 195.754 281.308 54.524 1.00 127.51 ? 188 LEU A CB  1 
ATOM 1344 C CG  . LEU A 1 188 ? 194.867 281.785 55.685 1.00 125.89 ? 188 LEU A CG  1 
ATOM 1345 C CD1 . LEU A 1 188 ? 194.361 283.211 55.506 1.00 124.62 ? 188 LEU A CD1 1 
ATOM 1346 C CD2 . LEU A 1 188 ? 193.693 280.829 55.896 1.00 120.80 ? 188 LEU A CD2 1 
ATOM 1347 N N   . SER A 1 189 ? 198.637 281.248 55.840 1.00 128.96 ? 189 SER A N   1 
ATOM 1348 C CA  . SER A 1 189 ? 199.511 281.280 57.003 1.00 128.90 ? 189 SER A CA  1 
ATOM 1349 C C   . SER A 1 189 ? 200.585 282.359 56.847 1.00 129.30 ? 189 SER A C   1 
ATOM 1350 O O   . SER A 1 189 ? 200.907 283.043 57.816 1.00 127.15 ? 189 SER A O   1 
ATOM 1351 C CB  . SER A 1 189 ? 200.126 279.925 57.251 1.00 129.02 ? 189 SER A CB  1 
ATOM 1352 O OG  . SER A 1 189 ? 199.117 278.935 57.401 1.00 126.15 ? 189 SER A OG  1 
ATOM 1353 N N   . GLN A 1 190 ? 201.127 282.503 55.628 1.00 130.16 ? 190 GLN A N   1 
ATOM 1354 C CA  . GLN A 1 190 ? 202.158 283.491 55.343 1.00 131.54 ? 190 GLN A CA  1 
ATOM 1355 C C   . GLN A 1 190 ? 201.576 284.904 55.371 1.00 129.84 ? 190 GLN A C   1 
ATOM 1356 O O   . GLN A 1 190 ? 202.272 285.842 55.759 1.00 129.44 ? 190 GLN A O   1 
ATOM 1357 C CB  . GLN A 1 190 ? 202.824 283.214 53.991 1.00 133.48 ? 190 GLN A CB  1 
ATOM 1358 C CG  . GLN A 1 190 ? 203.724 281.980 53.968 1.00 135.17 ? 190 GLN A CG  1 
ATOM 1359 C CD  . GLN A 1 190 ? 205.021 282.148 54.738 1.00 139.02 ? 190 GLN A CD  1 
ATOM 1360 O OE1 . GLN A 1 190 ? 205.378 283.247 55.186 1.00 137.38 ? 190 GLN A OE1 1 
ATOM 1361 N NE2 . GLN A 1 190 ? 205.754 281.050 54.891 1.00 139.82 ? 190 GLN A NE2 1 
ATOM 1362 N N   . ARG A 1 191 ? 200.317 285.054 54.933 1.00 129.31 ? 191 ARG A N   1 
ATOM 1363 C CA  . ARG A 1 191 ? 199.630 286.337 54.978 1.00 129.80 ? 191 ARG A CA  1 
ATOM 1364 C C   . ARG A 1 191 ? 199.441 286.768 56.432 1.00 126.93 ? 191 ARG A C   1 
ATOM 1365 O O   . ARG A 1 191 ? 199.753 287.902 56.786 1.00 127.99 ? 191 ARG A O   1 
ATOM 1366 C CB  . ARG A 1 191 ? 198.284 286.273 54.240 1.00 130.56 ? 191 ARG A CB  1 
ATOM 1367 C CG  . ARG A 1 191 ? 198.315 286.196 52.715 1.00 131.89 ? 191 ARG A CG  1 
ATOM 1368 C CD  . ARG A 1 191 ? 198.743 287.500 52.032 1.00 133.78 ? 191 ARG A CD  1 
ATOM 1369 N NE  . ARG A 1 191 ? 197.848 288.638 52.293 1.00 133.00 ? 191 ARG A NE  1 
ATOM 1370 C CZ  . ARG A 1 191 ? 198.140 289.941 52.159 1.00 134.62 ? 191 ARG A CZ  1 
ATOM 1371 N NH1 . ARG A 1 191 ? 197.196 290.852 52.365 1.00 134.28 ? 191 ARG A NH1 1 
ATOM 1372 N NH2 . ARG A 1 191 ? 199.356 290.343 51.804 1.00 136.48 ? 191 ARG A NH2 1 
ATOM 1373 N N   . LEU A 1 192 ? 198.950 285.847 57.272 1.00 126.33 ? 192 LEU A N   1 
ATOM 1374 C CA  . LEU A 1 192 ? 198.669 286.132 58.673 1.00 123.98 ? 192 LEU A CA  1 
ATOM 1375 C C   . LEU A 1 192 ? 199.960 286.380 59.450 1.00 123.67 ? 192 LEU A C   1 
ATOM 1376 O O   . LEU A 1 192 ? 199.973 287.202 60.366 1.00 125.30 ? 192 LEU A O   1 
ATOM 1377 C CB  . LEU A 1 192 ? 197.856 284.986 59.278 1.00 120.96 ? 192 LEU A CB  1 
ATOM 1378 C CG  . LEU A 1 192 ? 196.326 285.102 59.207 1.00 118.52 ? 192 LEU A CG  1 
ATOM 1379 C CD1 . LEU A 1 192 ? 195.788 285.657 57.893 1.00 122.81 ? 192 LEU A CD1 1 
ATOM 1380 C CD2 . LEU A 1 192 ? 195.703 283.737 59.486 1.00 112.43 ? 192 LEU A CD2 1 
ATOM 1381 N N   . ALA A 1 193 ? 201.035 285.667 59.090 1.00 124.73 ? 193 ALA A N   1 
ATOM 1382 C CA  . ALA A 1 193 ? 202.351 285.928 59.653 1.00 124.22 ? 193 ALA A CA  1 
ATOM 1383 C C   . ALA A 1 193 ? 202.783 287.363 59.348 1.00 128.23 ? 193 ALA A C   1 
ATOM 1384 O O   . ALA A 1 193 ? 203.302 288.040 60.233 1.00 129.52 ? 193 ALA A O   1 
ATOM 1385 C CB  . ALA A 1 193 ? 203.351 284.923 59.126 1.00 125.42 ? 193 ALA A CB  1 
ATOM 1386 N N   . ARG A 1 194 ? 202.559 287.821 58.104 1.00 127.87 ? 194 ARG A N   1 
ATOM 1387 C CA  . ARG A 1 194 ? 202.947 289.165 57.695 1.00 129.71 ? 194 ARG A CA  1 
ATOM 1388 C C   . ARG A 1 194 ? 202.113 290.210 58.440 1.00 129.77 ? 194 ARG A C   1 
ATOM 1389 O O   . ARG A 1 194 ? 202.627 291.279 58.762 1.00 132.12 ? 194 ARG A O   1 
ATOM 1390 C CB  . ARG A 1 194 ? 202.885 289.322 56.168 1.00 131.10 ? 194 ARG A CB  1 
ATOM 1391 C CG  . ARG A 1 194 ? 204.097 288.759 55.432 1.00 132.05 ? 194 ARG A CG  1 
ATOM 1392 C CD  . ARG A 1 194 ? 203.910 288.690 53.912 1.00 133.56 ? 194 ARG A CD  1 
ATOM 1393 N NE  . ARG A 1 194 ? 203.100 287.544 53.474 1.00 132.78 ? 194 ARG A NE  1 
ATOM 1394 C CZ  . ARG A 1 194 ? 202.736 287.244 52.220 1.00 134.29 ? 194 ARG A CZ  1 
ATOM 1395 N NH1 . ARG A 1 194 ? 202.085 286.114 51.976 1.00 133.20 ? 194 ARG A NH1 1 
ATOM 1396 N NH2 . ARG A 1 194 ? 203.033 288.044 51.206 1.00 135.51 ? 194 ARG A NH2 1 
ATOM 1397 N N   . LEU A 1 195 ? 200.841 289.900 58.724 1.00 128.50 ? 195 LEU A N   1 
ATOM 1398 C CA  . LEU A 1 195 ? 199.983 290.778 59.512 1.00 128.51 ? 195 LEU A CA  1 
ATOM 1399 C C   . LEU A 1 195 ? 200.517 290.916 60.936 1.00 128.70 ? 195 LEU A C   1 
ATOM 1400 O O   . LEU A 1 195 ? 200.463 292.005 61.506 1.00 131.31 ? 195 LEU A O   1 
ATOM 1401 C CB  . LEU A 1 195 ? 198.546 290.252 59.520 1.00 128.67 ? 195 LEU A CB  1 
ATOM 1402 C CG  . LEU A 1 195 ? 197.579 290.813 58.466 1.00 127.67 ? 195 LEU A CG  1 
ATOM 1403 C CD1 . LEU A 1 195 ? 198.098 290.860 57.025 1.00 128.35 ? 195 LEU A CD1 1 
ATOM 1404 C CD2 . LEU A 1 195 ? 196.312 289.971 58.545 1.00 124.22 ? 195 LEU A CD2 1 
ATOM 1405 N N   . ARG A 1 196 ? 201.003 289.801 61.502 1.00 128.22 ? 196 ARG A N   1 
ATOM 1406 C CA  . ARG A 1 196 ? 201.552 289.766 62.851 1.00 127.28 ? 196 ARG A CA  1 
ATOM 1407 C C   . ARG A 1 196 ? 202.860 290.560 62.940 1.00 130.81 ? 196 ARG A C   1 
ATOM 1408 O O   . ARG A 1 196 ? 203.181 291.089 64.004 1.00 131.97 ? 196 ARG A O   1 
ATOM 1409 C CB  . ARG A 1 196 ? 201.791 288.317 63.298 1.00 125.80 ? 196 ARG A CB  1 
ATOM 1410 C CG  . ARG A 1 196 ? 200.568 287.540 63.768 1.00 119.40 ? 196 ARG A CG  1 
ATOM 1411 C CD  . ARG A 1 196 ? 200.884 286.089 64.138 1.00 112.21 ? 196 ARG A CD  1 
ATOM 1412 N NE  . ARG A 1 196 ? 200.295 285.118 63.207 1.00 114.08 ? 196 ARG A NE  1 
ATOM 1413 C CZ  . ARG A 1 196 ? 200.887 284.097 62.584 1.00 114.26 ? 196 ARG A CZ  1 
ATOM 1414 N NH1 . ARG A 1 196 ? 200.151 283.236 61.892 1.00 112.30 ? 196 ARG A NH1 1 
ATOM 1415 N NH2 . ARG A 1 196 ? 202.191 283.898 62.668 1.00 113.86 ? 196 ARG A NH2 1 
ATOM 1416 N N   . ASP A 1 197 ? 203.619 290.616 61.834 1.00 131.75 ? 197 ASP A N   1 
ATOM 1417 C CA  . ASP A 1 197 ? 204.818 291.438 61.742 1.00 133.17 ? 197 ASP A CA  1 
ATOM 1418 C C   . ASP A 1 197 ? 204.440 292.917 61.637 1.00 134.52 ? 197 ASP A C   1 
ATOM 1419 O O   . ASP A 1 197 ? 205.049 293.757 62.300 1.00 135.06 ? 197 ASP A O   1 
ATOM 1420 C CB  . ASP A 1 197 ? 205.688 291.024 60.562 1.00 133.64 ? 197 ASP A CB  1 
ATOM 1421 C CG  . ASP A 1 197 ? 206.380 289.670 60.668 1.00 135.58 ? 197 ASP A CG  1 
ATOM 1422 O OD1 . ASP A 1 197 ? 206.502 289.150 61.805 1.00 135.37 ? 197 ASP A OD1 1 
ATOM 1423 O OD2 . ASP A 1 197 ? 206.787 289.134 59.608 1.00 135.25 ? 197 ASP A OD2 1 
ATOM 1424 N N   . GLN A 1 198 ? 203.431 293.217 60.802 1.00 134.03 ? 198 GLN A N   1 
ATOM 1425 C CA  . GLN A 1 198 ? 203.124 294.577 60.376 1.00 135.78 ? 198 GLN A CA  1 
ATOM 1426 C C   . GLN A 1 198 ? 202.454 295.387 61.487 1.00 136.43 ? 198 GLN A C   1 
ATOM 1427 O O   . GLN A 1 198 ? 202.466 296.617 61.429 1.00 137.00 ? 198 GLN A O   1 
ATOM 1428 C CB  . GLN A 1 198 ? 202.208 294.583 59.147 1.00 136.57 ? 198 GLN A CB  1 
ATOM 1429 C CG  . GLN A 1 198 ? 202.911 294.299 57.820 1.00 137.84 ? 198 GLN A CG  1 
ATOM 1430 C CD  . GLN A 1 198 ? 201.957 294.091 56.657 1.00 139.08 ? 198 GLN A CD  1 
ATOM 1431 O OE1 . GLN A 1 198 ? 200.735 294.251 56.782 1.00 139.97 ? 198 GLN A OE1 1 
ATOM 1432 N NE2 . GLN A 1 198 ? 202.507 293.735 55.501 1.00 139.78 ? 198 GLN A NE2 1 
ATOM 1433 N N   . VAL A 1 199 ? 201.863 294.707 62.484 1.00 136.21 ? 199 VAL A N   1 
ATOM 1434 C CA  . VAL A 1 199 ? 201.001 295.367 63.458 1.00 137.25 ? 199 VAL A CA  1 
ATOM 1435 C C   . VAL A 1 199 ? 201.835 296.357 64.300 1.00 138.14 ? 199 VAL A C   1 
ATOM 1436 O O   . VAL A 1 199 ? 202.967 295.980 64.703 1.00 136.97 ? 199 VAL A O   1 
ATOM 1437 C CB  . VAL A 1 199 ? 200.213 294.367 64.341 1.00 136.58 ? 199 VAL A CB  1 
ATOM 1438 C CG1 . VAL A 1 199 ? 201.096 293.602 65.330 1.00 136.77 ? 199 VAL A CG1 1 
ATOM 1439 C CG2 . VAL A 1 199 ? 199.051 295.043 65.069 1.00 135.28 ? 199 VAL A CG2 1 
ATOM 1440 O OXT . VAL A 1 199 ? 201.324 297.489 64.513 1.00 137.73 ? 199 VAL A OXT 1 
ATOM 1441 N N   . SER B 2 4   ? 223.458 274.257 96.568 1.00 111.04 ? 4   SER B N   1 
ATOM 1442 C CA  . SER B 2 4   ? 222.605 274.994 95.587 1.00 110.99 ? 4   SER B CA  1 
ATOM 1443 C C   . SER B 2 4   ? 221.515 274.083 95.011 1.00 108.90 ? 4   SER B C   1 
ATOM 1444 O O   . SER B 2 4   ? 220.441 274.560 94.635 1.00 107.48 ? 4   SER B O   1 
ATOM 1445 C CB  . SER B 2 4   ? 223.434 275.613 94.479 1.00 108.83 ? 4   SER B CB  1 
ATOM 1446 O OG  . SER B 2 4   ? 224.198 274.622 93.802 1.00 107.67 ? 4   SER B OG  1 
ATOM 1447 N N   . GLY B 2 5   ? 221.789 272.772 94.948 1.00 107.49 ? 5   GLY B N   1 
ATOM 1448 C CA  . GLY B 2 5   ? 220.868 271.822 94.352 1.00 105.77 ? 5   GLY B CA  1 
ATOM 1449 C C   . GLY B 2 5   ? 221.029 271.784 92.835 1.00 102.06 ? 5   GLY B C   1 
ATOM 1450 O O   . GLY B 2 5   ? 220.238 271.125 92.163 1.00 98.56  ? 5   GLY B O   1 
ATOM 1451 N N   . PHE B 2 6   ? 222.052 272.479 92.312 1.00 100.39 ? 6   PHE B N   1 
ATOM 1452 C CA  . PHE B 2 6   ? 222.291 272.528 90.881 1.00 96.63  ? 6   PHE B CA  1 
ATOM 1453 C C   . PHE B 2 6   ? 222.953 271.231 90.443 1.00 96.69  ? 6   PHE B C   1 
ATOM 1454 O O   . PHE B 2 6   ? 223.930 270.801 91.048 1.00 99.53  ? 6   PHE B O   1 
ATOM 1455 C CB  . PHE B 2 6   ? 223.179 273.702 90.480 1.00 98.53  ? 6   PHE B CB  1 
ATOM 1456 C CG  . PHE B 2 6   ? 223.656 273.645 89.037 1.00 97.85  ? 6   PHE B CG  1 
ATOM 1457 C CD1 . PHE B 2 6   ? 222.769 273.861 87.988 1.00 97.21  ? 6   PHE B CD1 1 
ATOM 1458 C CD2 . PHE B 2 6   ? 224.991 273.405 88.731 1.00 96.56  ? 6   PHE B CD2 1 
ATOM 1459 C CE1 . PHE B 2 6   ? 223.208 273.828 86.673 1.00 98.77  ? 6   PHE B CE1 1 
ATOM 1460 C CE2 . PHE B 2 6   ? 225.424 273.385 87.414 1.00 96.39  ? 6   PHE B CE2 1 
ATOM 1461 C CZ  . PHE B 2 6   ? 224.536 273.596 86.389 1.00 94.65  ? 6   PHE B CZ  1 
ATOM 1462 N N   . LYS B 2 7   ? 222.405 270.611 89.396 1.00 95.54  ? 7   LYS B N   1 
ATOM 1463 C CA  . LYS B 2 7   ? 223.012 269.435 88.795 1.00 96.18  ? 7   LYS B CA  1 
ATOM 1464 C C   . LYS B 2 7   ? 223.106 269.665 87.297 1.00 89.77  ? 7   LYS B C   1 
ATOM 1465 O O   . LYS B 2 7   ? 222.092 269.882 86.651 1.00 86.82  ? 7   LYS B O   1 
ATOM 1466 C CB  . LYS B 2 7   ? 222.181 268.182 89.063 1.00 95.26  ? 7   LYS B CB  1 
ATOM 1467 C CG  . LYS B 2 7   ? 222.035 267.841 90.532 1.00 101.98 ? 7   LYS B CG  1 
ATOM 1468 C CD  . LYS B 2 7   ? 221.509 266.426 90.775 1.00 108.87 ? 7   LYS B CD  1 
ATOM 1469 C CE  . LYS B 2 7   ? 221.611 265.988 92.220 1.00 111.75 ? 7   LYS B CE  1 
ATOM 1470 N NZ  . LYS B 2 7   ? 221.201 264.591 92.411 1.00 112.87 ? 7   LYS B NZ  1 
ATOM 1471 N N   . ALA B 2 8   ? 224.319 269.662 86.754 1.00 89.94  ? 8   ALA B N   1 
ATOM 1472 C CA  . ALA B 2 8   ? 224.474 269.992 85.352 1.00 88.41  ? 8   ALA B CA  1 
ATOM 1473 C C   . ALA B 2 8   ? 223.792 268.937 84.476 1.00 84.68  ? 8   ALA B C   1 
ATOM 1474 O O   . ALA B 2 8   ? 223.322 269.256 83.394 1.00 84.24  ? 8   ALA B O   1 
ATOM 1475 C CB  . ALA B 2 8   ? 225.934 270.153 85.015 1.00 89.82  ? 8   ALA B CB  1 
ATOM 1476 N N   . GLU B 2 9   ? 223.676 267.693 84.922 1.00 84.70  ? 9   GLU B N   1 
ATOM 1477 C CA  . GLU B 2 9   ? 223.075 266.715 84.035 1.00 84.98  ? 9   GLU B CA  1 
ATOM 1478 C C   . GLU B 2 9   ? 221.553 266.794 84.079 1.00 81.89  ? 9   GLU B C   1 
ATOM 1479 O O   . GLU B 2 9   ? 220.917 266.441 83.093 1.00 79.78  ? 9   GLU B O   1 
ATOM 1480 C CB  . GLU B 2 9   ? 223.614 265.302 84.261 1.00 87.87  ? 9   GLU B CB  1 
ATOM 1481 C CG  . GLU B 2 9   ? 225.057 265.146 83.770 1.00 90.50  ? 9   GLU B CG  1 
ATOM 1482 C CD  . GLU B 2 9   ? 225.423 265.819 82.443 1.00 91.22  ? 9   GLU B CD  1 
ATOM 1483 O OE1 . GLU B 2 9   ? 224.892 265.373 81.391 1.00 91.34  ? 9   GLU B OE1 1 
ATOM 1484 O OE2 . GLU B 2 9   ? 226.230 266.792 82.451 1.00 88.92  ? 9   GLU B OE2 1 
ATOM 1485 N N   . ARG B 2 10  ? 220.963 267.237 85.192 1.00 83.49  ? 10  ARG B N   1 
ATOM 1486 C CA  . ARG B 2 10  ? 219.549 267.574 85.210 1.00 80.28  ? 10  ARG B CA  1 
ATOM 1487 C C   . ARG B 2 10  ? 219.274 268.691 84.212 1.00 78.18  ? 10  ARG B C   1 
ATOM 1488 O O   . ARG B 2 10  ? 218.328 268.621 83.441 1.00 76.49  ? 10  ARG B O   1 
ATOM 1489 C CB  . ARG B 2 10  ? 219.072 268.058 86.576 1.00 82.16  ? 10  ARG B CB  1 
ATOM 1490 C CG  . ARG B 2 10  ? 218.760 266.907 87.516 1.00 87.47  ? 10  ARG B CG  1 
ATOM 1491 C CD  . ARG B 2 10  ? 217.293 266.545 87.529 1.00 88.19  ? 10  ARG B CD  1 
ATOM 1492 N NE  . ARG B 2 10  ? 216.553 267.499 88.357 1.00 87.29  ? 10  ARG B NE  1 
ATOM 1493 C CZ  . ARG B 2 10  ? 215.256 267.443 88.630 1.00 92.52  ? 10  ARG B CZ  1 
ATOM 1494 N NH1 . ARG B 2 10  ? 214.767 268.224 89.581 1.00 97.13  ? 10  ARG B NH1 1 
ATOM 1495 N NH2 . ARG B 2 10  ? 214.448 266.591 88.009 1.00 94.60  ? 10  ARG B NH2 1 
ATOM 1496 N N   . LEU B 2 11  ? 220.104 269.723 84.216 1.00 78.86  ? 11  LEU B N   1 
ATOM 1497 C CA  . LEU B 2 11  ? 219.866 270.814 83.303 1.00 79.26  ? 11  LEU B CA  1 
ATOM 1498 C C   . LEU B 2 11  ? 219.890 270.298 81.867 1.00 76.80  ? 11  LEU B C   1 
ATOM 1499 O O   . LEU B 2 11  ? 218.977 270.587 81.101 1.00 75.37  ? 11  LEU B O   1 
ATOM 1500 C CB  . LEU B 2 11  ? 220.866 271.948 83.502 1.00 79.67  ? 11  LEU B CB  1 
ATOM 1501 C CG  . LEU B 2 11  ? 220.581 273.195 82.660 1.00 78.92  ? 11  LEU B CG  1 
ATOM 1502 C CD1 . LEU B 2 11  ? 219.166 273.677 82.895 1.00 78.13  ? 11  LEU B CD1 1 
ATOM 1503 C CD2 . LEU B 2 11  ? 221.587 274.297 82.924 1.00 82.49  ? 11  LEU B CD2 1 
ATOM 1504 N N   . ARG B 2 12  ? 220.935 269.557 81.505 1.00 78.26  ? 12  ARG B N   1 
ATOM 1505 C CA  . ARG B 2 12  ? 221.120 269.118 80.132 1.00 78.87  ? 12  ARG B CA  1 
ATOM 1506 C C   . ARG B 2 12  ? 219.963 268.210 79.678 1.00 73.41  ? 12  ARG B C   1 
ATOM 1507 O O   . ARG B 2 12  ? 219.460 268.371 78.574 1.00 73.98  ? 12  ARG B O   1 
ATOM 1508 C CB  . ARG B 2 12  ? 222.484 268.435 79.972 1.00 80.03  ? 12  ARG B CB  1 
ATOM 1509 C CG  . ARG B 2 12  ? 222.991 268.392 78.540 1.00 79.55  ? 12  ARG B CG  1 
ATOM 1510 C CD  . ARG B 2 12  ? 223.891 267.192 78.302 1.00 86.21  ? 12  ARG B CD  1 
ATOM 1511 N NE  . ARG B 2 12  ? 225.083 267.269 79.154 1.00 89.90  ? 12  ARG B NE  1 
ATOM 1512 C CZ  . ARG B 2 12  ? 226.141 268.084 79.007 1.00 89.51  ? 12  ARG B CZ  1 
ATOM 1513 N NH1 . ARG B 2 12  ? 227.055 268.123 79.972 1.00 91.83  ? 12  ARG B NH1 1 
ATOM 1514 N NH2 . ARG B 2 12  ? 226.290 268.854 77.930 1.00 85.68  ? 12  ARG B NH2 1 
ATOM 1515 N N   . VAL B 2 13  ? 219.537 267.261 80.506 1.00 72.93  ? 13  VAL B N   1 
ATOM 1516 C CA  . VAL B 2 13  ? 218.488 266.333 80.114 1.00 71.94  ? 13  VAL B CA  1 
ATOM 1517 C C   . VAL B 2 13  ? 217.165 267.070 79.905 1.00 70.89  ? 13  VAL B C   1 
ATOM 1518 O O   . VAL B 2 13  ? 216.444 266.761 78.964 1.00 70.78  ? 13  VAL B O   1 
ATOM 1519 C CB  . VAL B 2 13  ? 218.342 265.196 81.145 1.00 70.78  ? 13  VAL B CB  1 
ATOM 1520 C CG1 . VAL B 2 13  ? 217.015 264.460 81.042 1.00 73.39  ? 13  VAL B CG1 1 
ATOM 1521 C CG2 . VAL B 2 13  ? 219.477 264.198 81.032 1.00 72.84  ? 13  VAL B CG2 1 
ATOM 1522 N N   . ASN B 2 14  ? 216.844 268.028 80.779 1.00 72.75  ? 14  ASN B N   1 
ATOM 1523 C CA  . ASN B 2 14  ? 215.576 268.733 80.712 1.00 69.41  ? 14  ASN B CA  1 
ATOM 1524 C C   . ASN B 2 14  ? 215.598 269.755 79.590 1.00 68.99  ? 14  ASN B C   1 
ATOM 1525 O O   . ASN B 2 14  ? 214.554 269.971 79.008 1.00 71.08  ? 14  ASN B O   1 
ATOM 1526 C CB  . ASN B 2 14  ? 215.163 269.314 82.057 1.00 68.07  ? 14  ASN B CB  1 
ATOM 1527 C CG  . ASN B 2 14  ? 214.662 268.221 82.968 1.00 69.87  ? 14  ASN B CG  1 
ATOM 1528 O OD1 . ASN B 2 14  ? 213.480 267.868 82.949 1.00 71.47  ? 14  ASN B OD1 1 
ATOM 1529 N ND2 . ASN B 2 14  ? 215.546 267.634 83.755 1.00 74.06  ? 14  ASN B ND2 1 
ATOM 1530 N N   . LEU B 2 15  ? 216.732 270.368 79.256 1.00 69.72  ? 15  LEU B N   1 
ATOM 1531 C CA  . LEU B 2 15  ? 216.769 271.235 78.091 1.00 68.93  ? 15  LEU B CA  1 
ATOM 1532 C C   . LEU B 2 15  ? 216.394 270.444 76.836 1.00 70.32  ? 15  LEU B C   1 
ATOM 1533 O O   . LEU B 2 15  ? 215.725 270.970 75.954 1.00 71.62  ? 15  LEU B O   1 
ATOM 1534 C CB  . LEU B 2 15  ? 218.143 271.874 77.929 1.00 71.62  ? 15  LEU B CB  1 
ATOM 1535 C CG  . LEU B 2 15  ? 218.472 273.068 78.827 1.00 74.00  ? 15  LEU B CG  1 
ATOM 1536 C CD1 . LEU B 2 15  ? 219.957 273.370 78.733 1.00 77.45  ? 15  LEU B CD1 1 
ATOM 1537 C CD2 . LEU B 2 15  ? 217.690 274.327 78.483 1.00 75.46  ? 15  LEU B CD2 1 
ATOM 1538 N N   . ARG B 2 16  ? 216.874 269.206 76.721 1.00 70.94  ? 16  ARG B N   1 
ATOM 1539 C CA  . ARG B 2 16  ? 216.619 268.383 75.558 1.00 70.96  ? 16  ARG B CA  1 
ATOM 1540 C C   . ARG B 2 16  ? 215.132 268.034 75.520 1.00 71.43  ? 16  ARG B C   1 
ATOM 1541 O O   . ARG B 2 16  ? 214.529 268.008 74.450 1.00 72.18  ? 16  ARG B O   1 
ATOM 1542 C CB  . ARG B 2 16  ? 217.440 267.088 75.614 1.00 77.61  ? 16  ARG B CB  1 
ATOM 1543 C CG  . ARG B 2 16  ? 218.958 267.161 75.500 1.00 82.43  ? 16  ARG B CG  1 
ATOM 1544 C CD  . ARG B 2 16  ? 219.424 267.006 74.075 1.00 91.29  ? 16  ARG B CD  1 
ATOM 1545 N NE  . ARG B 2 16  ? 220.867 267.225 73.917 1.00 93.38  ? 16  ARG B NE  1 
ATOM 1546 C CZ  . ARG B 2 16  ? 221.477 267.446 72.745 1.00 101.40 ? 16  ARG B CZ  1 
ATOM 1547 N NH1 . ARG B 2 16  ? 222.761 267.797 72.733 1.00 104.21 ? 16  ARG B NH1 1 
ATOM 1548 N NH2 . ARG B 2 16  ? 220.803 267.370 71.596 1.00 101.81 ? 16  ARG B NH2 1 
ATOM 1549 N N   . LEU B 2 17  ? 214.543 267.737 76.685 1.00 70.75  ? 17  LEU B N   1 
ATOM 1550 C CA  . LEU B 2 17  ? 213.128 267.400 76.776 1.00 67.02  ? 17  LEU B CA  1 
ATOM 1551 C C   . LEU B 2 17  ? 212.265 268.608 76.420 1.00 67.04  ? 17  LEU B C   1 
ATOM 1552 O O   . LEU B 2 17  ? 211.250 268.455 75.760 1.00 69.71  ? 17  LEU B O   1 
ATOM 1553 C CB  . LEU B 2 17  ? 212.780 266.885 78.165 1.00 64.73  ? 17  LEU B CB  1 
ATOM 1554 C CG  . LEU B 2 17  ? 213.325 265.498 78.512 1.00 64.44  ? 17  LEU B CG  1 
ATOM 1555 C CD1 . LEU B 2 17  ? 213.040 265.209 79.965 1.00 66.65  ? 17  LEU B CD1 1 
ATOM 1556 C CD2 . LEU B 2 17  ? 212.775 264.373 77.669 1.00 66.65  ? 17  LEU B CD2 1 
ATOM 1557 N N   . VAL B 2 18  ? 212.641 269.803 76.852 1.00 67.75  ? 18  VAL B N   1 
ATOM 1558 C CA  . VAL B 2 18  ? 211.883 270.992 76.510 1.00 68.90  ? 18  VAL B CA  1 
ATOM 1559 C C   . VAL B 2 18  ? 211.890 271.167 74.994 1.00 67.84  ? 18  VAL B C   1 
ATOM 1560 O O   . VAL B 2 18  ? 210.866 271.496 74.421 1.00 69.66  ? 18  VAL B O   1 
ATOM 1561 C CB  . VAL B 2 18  ? 212.403 272.253 77.234 1.00 68.68  ? 18  VAL B CB  1 
ATOM 1562 C CG1 . VAL B 2 18  ? 211.851 273.542 76.642 1.00 70.57  ? 18  VAL B CG1 1 
ATOM 1563 C CG2 . VAL B 2 18  ? 212.107 272.193 78.719 1.00 70.60  ? 18  VAL B CG2 1 
ATOM 1564 N N   . ILE B 2 19  ? 213.032 270.949 74.346 1.00 69.42  ? 19  ILE B N   1 
ATOM 1565 C CA  . ILE B 2 19  ? 213.109 271.126 72.904 1.00 71.97  ? 19  ILE B CA  1 
ATOM 1566 C C   . ILE B 2 19  ? 212.181 270.136 72.200 1.00 69.41  ? 19  ILE B C   1 
ATOM 1567 O O   . ILE B 2 19  ? 211.462 270.526 71.289 1.00 72.69  ? 19  ILE B O   1 
ATOM 1568 C CB  . ILE B 2 19  ? 214.563 271.025 72.409 1.00 69.46  ? 19  ILE B CB  1 
ATOM 1569 C CG1 . ILE B 2 19  ? 215.330 272.259 72.808 1.00 72.20  ? 19  ILE B CG1 1 
ATOM 1570 C CG2 . ILE B 2 19  ? 214.613 270.792 70.901 1.00 73.44  ? 19  ILE B CG2 1 
ATOM 1571 C CD1 . ILE B 2 19  ? 216.807 272.199 72.516 1.00 78.68  ? 19  ILE B CD1 1 
ATOM 1572 N N   . ASN B 2 20  ? 212.175 268.880 72.629 1.00 67.98  ? 20  ASN B N   1 
ATOM 1573 C CA  . ASN B 2 20  ? 211.311 267.900 72.010 1.00 70.09  ? 20  ASN B CA  1 
ATOM 1574 C C   . ASN B 2 20  ? 209.848 268.252 72.214 1.00 70.99  ? 20  ASN B C   1 
ATOM 1575 O O   . ASN B 2 20  ? 209.059 268.095 71.286 1.00 72.63  ? 20  ASN B O   1 
ATOM 1576 C CB  . ASN B 2 20  ? 211.526 266.496 72.546 1.00 72.33  ? 20  ASN B CB  1 
ATOM 1577 C CG  . ASN B 2 20  ? 212.837 265.935 72.076 1.00 75.39  ? 20  ASN B CG  1 
ATOM 1578 O OD1 . ASN B 2 20  ? 213.415 266.441 71.103 1.00 74.82  ? 20  ASN B OD1 1 
ATOM 1579 N ND2 . ASN B 2 20  ? 213.311 264.898 72.758 1.00 82.10  ? 20  ASN B ND2 1 
ATOM 1580 N N   . ARG B 2 21  ? 209.486 268.692 73.419 1.00 70.09  ? 21  ARG B N   1 
ATOM 1581 C CA  . ARG B 2 21  ? 208.094 268.952 73.718 1.00 67.50  ? 21  ARG B CA  1 
ATOM 1582 C C   . ARG B 2 21  ? 207.639 270.164 72.918 1.00 68.01  ? 21  ARG B C   1 
ATOM 1583 O O   . ARG B 2 21  ? 206.558 270.139 72.365 1.00 73.19  ? 21  ARG B O   1 
ATOM 1584 C CB  . ARG B 2 21  ? 207.824 269.065 75.222 1.00 67.72  ? 21  ARG B CB  1 
ATOM 1585 C CG  . ARG B 2 21  ? 206.355 268.781 75.499 1.00 69.61  ? 21  ARG B CG  1 
ATOM 1586 C CD  . ARG B 2 21  ? 205.917 268.939 76.928 1.00 72.80  ? 21  ARG B CD  1 
ATOM 1587 N NE  . ARG B 2 21  ? 206.459 267.873 77.772 1.00 72.77  ? 21  ARG B NE  1 
ATOM 1588 C CZ  . ARG B 2 21  ? 205.890 266.701 77.958 1.00 68.11  ? 21  ARG B CZ  1 
ATOM 1589 N NH1 . ARG B 2 21  ? 206.418 265.833 78.790 1.00 70.37  ? 21  ARG B NH1 1 
ATOM 1590 N NH2 . ARG B 2 21  ? 204.782 266.390 77.335 1.00 65.43  ? 21  ARG B NH2 1 
ATOM 1591 N N   . LEU B 2 22  ? 208.451 271.209 72.832 1.00 70.70  ? 22  LEU B N   1 
ATOM 1592 C CA  . LEU B 2 22  ? 208.059 272.409 72.112 1.00 71.96  ? 22  LEU B CA  1 
ATOM 1593 C C   . LEU B 2 22  ? 207.870 272.105 70.628 1.00 73.17  ? 22  LEU B C   1 
ATOM 1594 O O   . LEU B 2 22  ? 206.966 272.648 70.014 1.00 75.13  ? 22  LEU B O   1 
ATOM 1595 C CB  . LEU B 2 22  ? 209.090 273.518 72.309 1.00 71.11  ? 22  LEU B CB  1 
ATOM 1596 C CG  . LEU B 2 22  ? 209.159 274.166 73.696 1.00 72.84  ? 22  LEU B CG  1 
ATOM 1597 C CD1 . LEU B 2 22  ? 210.349 275.122 73.755 1.00 78.47  ? 22  LEU B CD1 1 
ATOM 1598 C CD2 . LEU B 2 22  ? 207.899 274.899 74.080 1.00 77.22  ? 22  LEU B CD2 1 
ATOM 1599 N N   . LYS B 2 23  ? 208.717 271.243 70.055 1.00 73.26  ? 23  LYS B N   1 
ATOM 1600 C CA  . LYS B 2 23  ? 208.616 270.884 68.646 1.00 75.85  ? 23  LYS B CA  1 
ATOM 1601 C C   . LYS B 2 23  ? 207.308 270.141 68.372 1.00 74.93  ? 23  LYS B C   1 
ATOM 1602 O O   . LYS B 2 23  ? 206.695 270.326 67.325 1.00 75.50  ? 23  LYS B O   1 
ATOM 1603 C CB  . LYS B 2 23  ? 209.856 270.103 68.188 1.00 75.43  ? 23  LYS B CB  1 
ATOM 1604 C CG  . LYS B 2 23  ? 211.038 271.051 67.984 1.00 80.63  ? 23  LYS B CG  1 
ATOM 1605 C CD  . LYS B 2 23  ? 212.431 270.439 67.887 1.00 84.43  ? 23  LYS B CD  1 
ATOM 1606 C CE  . LYS B 2 23  ? 212.622 269.514 66.725 1.00 89.93  ? 23  LYS B CE  1 
ATOM 1607 N NZ  . LYS B 2 23  ? 213.954 268.901 66.768 1.00 92.03  ? 23  LYS B NZ  1 
ATOM 1608 N N   . LEU B 2 24  ? 206.887 269.312 69.319 1.00 73.75  ? 24  LEU B N   1 
ATOM 1609 C CA  . LEU B 2 24  ? 205.688 268.510 69.178 1.00 73.60  ? 24  LEU B CA  1 
ATOM 1610 C C   . LEU B 2 24  ? 204.455 269.386 69.350 1.00 74.77  ? 24  LEU B C   1 
ATOM 1611 O O   . LEU B 2 24  ? 203.481 269.199 68.633 1.00 77.11  ? 24  LEU B O   1 
ATOM 1612 C CB  . LEU B 2 24  ? 205.821 267.412 70.230 1.00 74.69  ? 24  LEU B CB  1 
ATOM 1613 C CG  . LEU B 2 24  ? 204.908 266.184 70.170 1.00 79.20  ? 24  LEU B CG  1 
ATOM 1614 C CD1 . LEU B 2 24  ? 203.559 266.418 70.857 1.00 81.50  ? 24  LEU B CD1 1 
ATOM 1615 C CD2 . LEU B 2 24  ? 204.727 265.674 68.746 1.00 82.56  ? 24  LEU B CD2 1 
ATOM 1616 N N   . LEU B 2 25  ? 204.507 270.357 70.268 1.00 74.74  ? 25  LEU B N   1 
ATOM 1617 C CA  . LEU B 2 25  ? 203.426 271.310 70.477 1.00 73.06  ? 25  LEU B CA  1 
ATOM 1618 C C   . LEU B 2 25  ? 203.294 272.288 69.316 1.00 73.56  ? 25  LEU B C   1 
ATOM 1619 O O   . LEU B 2 25  ? 202.181 272.609 68.954 1.00 75.94  ? 25  LEU B O   1 
ATOM 1620 C CB  . LEU B 2 25  ? 203.599 272.097 71.773 1.00 75.00  ? 25  LEU B CB  1 
ATOM 1621 C CG  . LEU B 2 25  ? 203.393 271.303 73.068 1.00 76.30  ? 25  LEU B CG  1 
ATOM 1622 C CD1 . LEU B 2 25  ? 203.683 272.158 74.293 1.00 76.72  ? 25  LEU B CD1 1 
ATOM 1623 C CD2 . LEU B 2 25  ? 202.000 270.711 73.170 1.00 79.41  ? 25  LEU B CD2 1 
ATOM 1624 N N   . GLU B 2 26  ? 204.391 272.811 68.771 1.00 75.15  ? 26  GLU B N   1 
ATOM 1625 C CA  . GLU B 2 26  ? 204.302 273.750 67.664 1.00 76.34  ? 26  GLU B CA  1 
ATOM 1626 C C   . GLU B 2 26  ? 203.526 273.125 66.510 1.00 75.41  ? 26  GLU B C   1 
ATOM 1627 O O   . GLU B 2 26  ? 202.700 273.795 65.905 1.00 76.99  ? 26  GLU B O   1 
ATOM 1628 C CB  . GLU B 2 26  ? 205.661 274.182 67.115 1.00 78.11  ? 26  GLU B CB  1 
ATOM 1629 C CG  . GLU B 2 26  ? 206.428 275.140 68.025 1.00 82.06  ? 26  GLU B CG  1 
ATOM 1630 C CD  . GLU B 2 26  ? 207.928 275.184 67.724 1.00 88.77  ? 26  GLU B CD  1 
ATOM 1631 O OE1 . GLU B 2 26  ? 208.267 275.163 66.510 1.00 92.88  ? 26  GLU B OE1 1 
ATOM 1632 O OE2 . GLU B 2 26  ? 208.760 275.252 68.674 1.00 84.34  ? 26  GLU B OE2 1 
ATOM 1633 N N   . LYS B 2 27  ? 203.818 271.861 66.201 1.00 74.60  ? 27  LYS B N   1 
ATOM 1634 C CA  . LYS B 2 27  ? 203.170 271.166 65.110 1.00 75.50  ? 27  LYS B CA  1 
ATOM 1635 C C   . LYS B 2 27  ? 201.679 271.045 65.388 1.00 76.09  ? 27  LYS B C   1 
ATOM 1636 O O   . LYS B 2 27  ? 200.872 271.363 64.521 1.00 76.76  ? 27  LYS B O   1 
ATOM 1637 C CB  . LYS B 2 27  ? 203.721 269.754 64.909 1.00 79.25  ? 27  LYS B CB  1 
ATOM 1638 C CG  . LYS B 2 27  ? 204.983 269.695 64.088 1.00 83.76  ? 27  LYS B CG  1 
ATOM 1639 C CD  . LYS B 2 27  ? 205.418 268.264 63.791 1.00 90.80  ? 27  LYS B CD  1 
ATOM 1640 C CE  . LYS B 2 27  ? 206.727 268.216 63.020 1.00 97.43  ? 27  LYS B CE  1 
ATOM 1641 N NZ  . LYS B 2 27  ? 207.915 268.545 63.830 1.00 99.29  ? 27  LYS B NZ  1 
ATOM 1642 N N   . LYS B 2 28  ? 201.336 270.573 66.589 1.00 75.45  ? 28  LYS B N   1 
ATOM 1643 C CA  . LYS B 2 28  ? 199.955 270.327 66.965 1.00 73.15  ? 28  LYS B CA  1 
ATOM 1644 C C   . LYS B 2 28  ? 199.147 271.621 66.955 1.00 72.71  ? 28  LYS B C   1 
ATOM 1645 O O   . LYS B 2 28  ? 198.076 271.662 66.377 1.00 75.63  ? 28  LYS B O   1 
ATOM 1646 C CB  . LYS B 2 28  ? 199.930 269.643 68.329 1.00 72.68  ? 28  LYS B CB  1 
ATOM 1647 C CG  . LYS B 2 28  ? 198.566 269.302 68.826 1.00 72.26  ? 28  LYS B CG  1 
ATOM 1648 C CD  . LYS B 2 28  ? 198.576 268.372 70.023 1.00 75.24  ? 28  LYS B CD  1 
ATOM 1649 C CE  . LYS B 2 28  ? 197.260 268.365 70.751 1.00 77.87  ? 28  LYS B CE  1 
ATOM 1650 N NZ  . LYS B 2 28  ? 197.162 267.233 71.687 1.00 76.57  ? 28  LYS B NZ  1 
ATOM 1651 N N   . LYS B 2 29  ? 199.653 272.680 67.574 1.00 73.64  ? 29  LYS B N   1 
ATOM 1652 C CA  . LYS B 2 29  ? 198.939 273.941 67.610 1.00 73.98  ? 29  LYS B CA  1 
ATOM 1653 C C   . LYS B 2 29  ? 198.782 274.529 66.213 1.00 77.08  ? 29  LYS B C   1 
ATOM 1654 O O   . LYS B 2 29  ? 197.801 275.217 65.957 1.00 78.63  ? 29  LYS B O   1 
ATOM 1655 C CB  . LYS B 2 29  ? 199.638 274.963 68.506 1.00 75.82  ? 29  LYS B CB  1 
ATOM 1656 C CG  . LYS B 2 29  ? 199.524 274.628 69.966 1.00 79.45  ? 29  LYS B CG  1 
ATOM 1657 C CD  . LYS B 2 29  ? 200.139 275.653 70.903 1.00 82.38  ? 29  LYS B CD  1 
ATOM 1658 C CE  . LYS B 2 29  ? 199.992 275.205 72.322 1.00 87.21  ? 29  LYS B CE  1 
ATOM 1659 N NZ  . LYS B 2 29  ? 198.617 275.281 72.811 1.00 89.19  ? 29  LYS B NZ  1 
ATOM 1660 N N   . THR B 2 30  ? 199.744 274.290 65.321 1.00 75.83  ? 30  THR B N   1 
ATOM 1661 C CA  . THR B 2 30  ? 199.645 274.824 63.974 1.00 76.75  ? 30  THR B CA  1 
ATOM 1662 C C   . THR B 2 30  ? 198.522 274.117 63.216 1.00 77.89  ? 30  THR B C   1 
ATOM 1663 O O   . THR B 2 30  ? 197.781 274.749 62.477 1.00 82.00  ? 30  THR B O   1 
ATOM 1664 C CB  . THR B 2 30  ? 201.003 274.697 63.287 1.00 79.28  ? 30  THR B CB  1 
ATOM 1665 O OG1 . THR B 2 30  ? 201.807 275.717 63.872 1.00 77.82  ? 30  THR B OG1 1 
ATOM 1666 C CG2 . THR B 2 30  ? 200.960 274.953 61.792 1.00 81.75  ? 30  THR B CG2 1 
ATOM 1667 N N   . GLU B 2 31  ? 198.400 272.804 63.402 1.00 78.65  ? 31  GLU B N   1 
ATOM 1668 C CA  . GLU B 2 31  ? 197.347 272.021 62.783 1.00 78.59  ? 31  GLU B CA  1 
ATOM 1669 C C   . GLU B 2 31  ? 195.975 272.473 63.268 1.00 80.97  ? 31  GLU B C   1 
ATOM 1670 O O   . GLU B 2 31  ? 195.063 272.609 62.458 1.00 84.21  ? 31  GLU B O   1 
ATOM 1671 C CB  . GLU B 2 31  ? 197.518 270.543 63.114 1.00 79.08  ? 31  GLU B CB  1 
ATOM 1672 C CG  . GLU B 2 31  ? 196.548 269.633 62.367 1.00 83.79  ? 31  GLU B CG  1 
ATOM 1673 C CD  . GLU B 2 31  ? 196.398 269.966 60.880 1.00 87.90  ? 31  GLU B CD  1 
ATOM 1674 O OE1 . GLU B 2 31  ? 197.449 270.060 60.184 1.00 86.27  ? 31  GLU B OE1 1 
ATOM 1675 O OE2 . GLU B 2 31  ? 195.239 270.146 60.406 1.00 86.25  ? 31  GLU B OE2 1 
ATOM 1676 N N   . LEU B 2 32  ? 195.831 272.684 64.583 1.00 79.37  ? 32  LEU B N   1 
ATOM 1677 C CA  . LEU B 2 32  ? 194.557 273.048 65.177 1.00 76.90  ? 32  LEU B CA  1 
ATOM 1678 C C   . LEU B 2 32  ? 194.157 274.446 64.722 1.00 80.51  ? 32  LEU B C   1 
ATOM 1679 O O   . LEU B 2 32  ? 192.976 274.753 64.705 1.00 85.84  ? 32  LEU B O   1 
ATOM 1680 C CB  . LEU B 2 32  ? 194.585 272.987 66.702 1.00 76.97  ? 32  LEU B CB  1 
ATOM 1681 C CG  . LEU B 2 32  ? 194.839 271.621 67.342 1.00 74.57  ? 32  LEU B CG  1 
ATOM 1682 C CD1 . LEU B 2 32  ? 195.129 271.775 68.822 1.00 73.15  ? 32  LEU B CD1 1 
ATOM 1683 C CD2 . LEU B 2 32  ? 193.709 270.649 67.129 1.00 77.86  ? 32  LEU B CD2 1 
ATOM 1684 N N   . ALA B 2 33  ? 195.123 275.295 64.383 1.00 80.85  ? 33  ALA B N   1 
ATOM 1685 C CA  . ALA B 2 33  ? 194.817 276.643 63.929 1.00 84.87  ? 33  ALA B CA  1 
ATOM 1686 C C   . ALA B 2 33  ? 194.145 276.594 62.563 1.00 86.21  ? 33  ALA B C   1 
ATOM 1687 O O   . ALA B 2 33  ? 193.285 277.418 62.281 1.00 90.15  ? 33  ALA B O   1 
ATOM 1688 C CB  . ALA B 2 33  ? 196.067 277.504 63.880 1.00 87.27  ? 33  ALA B CB  1 
ATOM 1689 N N   . GLN B 2 34  ? 194.549 275.635 61.728 1.00 87.95  ? 34  GLN B N   1 
ATOM 1690 C CA  . GLN B 2 34  ? 193.946 275.466 60.417 1.00 92.03  ? 34  GLN B CA  1 
ATOM 1691 C C   . GLN B 2 34  ? 192.466 275.114 60.578 1.00 91.03  ? 34  GLN B C   1 
ATOM 1692 O O   . GLN B 2 34  ? 191.616 275.691 59.900 1.00 90.42  ? 34  GLN B O   1 
ATOM 1693 C CB  . GLN B 2 34  ? 194.719 274.437 59.583 1.00 94.36  ? 34  GLN B CB  1 
ATOM 1694 C CG  . GLN B 2 34  ? 196.083 274.934 59.111 1.00 96.18  ? 34  GLN B CG  1 
ATOM 1695 C CD  . GLN B 2 34  ? 195.992 276.128 58.173 1.00 104.28 ? 34  GLN B CD  1 
ATOM 1696 O OE1 . GLN B 2 34  ? 196.036 277.294 58.600 1.00 102.77 ? 34  GLN B OE1 1 
ATOM 1697 N NE2 . GLN B 2 34  ? 195.830 275.853 56.882 1.00 114.92 ? 34  GLN B NE2 1 
ATOM 1698 N N   . LYS B 2 35  ? 192.163 274.181 61.488 1.00 87.24  ? 35  LYS B N   1 
ATOM 1699 C CA  . LYS B 2 35  ? 190.789 273.788 61.752 1.00 87.37  ? 35  LYS B CA  1 
ATOM 1700 C C   . LYS B 2 35  ? 189.976 274.958 62.318 1.00 88.89  ? 35  LYS B C   1 
ATOM 1701 O O   . LYS B 2 35  ? 188.801 275.102 62.008 1.00 92.75  ? 35  LYS B O   1 
ATOM 1702 C CB  . LYS B 2 35  ? 190.790 272.569 62.676 1.00 86.25  ? 35  LYS B CB  1 
ATOM 1703 C CG  . LYS B 2 35  ? 191.240 271.280 62.013 1.00 86.13  ? 35  LYS B CG  1 
ATOM 1704 C CD  . LYS B 2 35  ? 191.720 270.225 63.001 1.00 87.87  ? 35  LYS B CD  1 
ATOM 1705 C CE  . LYS B 2 35  ? 191.899 268.831 62.460 1.00 88.48  ? 35  LYS B CE  1 
ATOM 1706 N NZ  . LYS B 2 35  ? 193.010 268.668 61.522 1.00 87.30  ? 35  LYS B NZ  1 
ATOM 1707 N N   . ALA B 2 36  ? 190.595 275.793 63.146 1.00 88.72  ? 36  ALA B N   1 
ATOM 1708 C CA  . ALA B 2 36  ? 189.912 276.908 63.770 1.00 87.74  ? 36  ALA B CA  1 
ATOM 1709 C C   . ALA B 2 36  ? 189.621 278.007 62.756 1.00 92.53  ? 36  ALA B C   1 
ATOM 1710 O O   . ALA B 2 36  ? 188.632 278.716 62.905 1.00 95.83  ? 36  ALA B O   1 
ATOM 1711 C CB  . ALA B 2 36  ? 190.755 277.434 64.904 1.00 90.81  ? 36  ALA B CB  1 
ATOM 1712 N N   . ARG B 2 37  ? 190.498 278.178 61.757 1.00 93.90  ? 37  ARG B N   1 
ATOM 1713 C CA  . ARG B 2 37  ? 190.315 279.204 60.735 1.00 94.84  ? 37  ARG B CA  1 
ATOM 1714 C C   . ARG B 2 37  ? 189.088 278.877 59.884 1.00 95.78  ? 37  ARG B C   1 
ATOM 1715 O O   . ARG B 2 37  ? 188.462 279.783 59.352 1.00 100.97 ? 37  ARG B O   1 
ATOM 1716 C CB  . ARG B 2 37  ? 191.541 279.360 59.821 1.00 95.57  ? 37  ARG B CB  1 
ATOM 1717 C CG  . ARG B 2 37  ? 192.785 279.987 60.435 1.00 96.59  ? 37  ARG B CG  1 
ATOM 1718 C CD  . ARG B 2 37  ? 193.936 280.126 59.436 1.00 100.61 ? 37  ARG B CD  1 
ATOM 1719 N NE  . ARG B 2 37  ? 195.266 279.743 59.928 1.00 99.41  ? 37  ARG B NE  1 
ATOM 1720 C CZ  . ARG B 2 37  ? 195.963 280.264 60.948 1.00 103.74 ? 37  ARG B CZ  1 
ATOM 1721 N NH1 . ARG B 2 37  ? 197.148 279.749 61.253 1.00 102.20 ? 37  ARG B NH1 1 
ATOM 1722 N NH2 . ARG B 2 37  ? 195.507 281.273 61.678 1.00 101.24 ? 37  ARG B NH2 1 
ATOM 1723 N N   . LYS B 2 38  ? 188.778 277.585 59.737 1.00 95.87  ? 38  LYS B N   1 
ATOM 1724 C CA  . LYS B 2 38  ? 187.610 277.122 59.007 1.00 97.78  ? 38  LYS B CA  1 
ATOM 1725 C C   . LYS B 2 38  ? 186.337 277.459 59.785 1.00 100.77 ? 38  LYS B C   1 
ATOM 1726 O O   . LYS B 2 38  ? 185.351 277.896 59.196 1.00 103.16 ? 38  LYS B O   1 
ATOM 1727 C CB  . LYS B 2 38  ? 187.773 275.620 58.741 1.00 100.72 ? 38  LYS B CB  1 
ATOM 1728 C CG  . LYS B 2 38  ? 186.628 274.879 58.057 1.00 104.15 ? 38  LYS B CG  1 
ATOM 1729 C CD  . LYS B 2 38  ? 186.233 275.427 56.687 1.00 108.82 ? 38  LYS B CD  1 
ATOM 1730 C CE  . LYS B 2 38  ? 185.125 274.655 56.005 1.00 112.70 ? 38  LYS B CE  1 
ATOM 1731 N NZ  . LYS B 2 38  ? 183.811 274.691 56.666 1.00 111.37 ? 38  LYS B NZ  1 
ATOM 1732 N N   . GLU B 2 39  ? 186.365 277.261 61.106 1.00 98.54  ? 39  GLU B N   1 
ATOM 1733 C CA  . GLU B 2 39  ? 185.273 277.654 61.979 1.00 97.76  ? 39  GLU B CA  1 
ATOM 1734 C C   . GLU B 2 39  ? 184.979 279.148 61.826 1.00 99.73  ? 39  GLU B C   1 
ATOM 1735 O O   . GLU B 2 39  ? 183.818 279.527 61.800 1.00 103.14 ? 39  GLU B O   1 
ATOM 1736 C CB  . GLU B 2 39  ? 185.620 277.274 63.419 1.00 100.31 ? 39  GLU B CB  1 
ATOM 1737 C CG  . GLU B 2 39  ? 184.430 277.206 64.372 1.00 103.42 ? 39  GLU B CG  1 
ATOM 1738 C CD  . GLU B 2 39  ? 184.717 277.347 65.870 1.00 104.86 ? 39  GLU B CD  1 
ATOM 1739 O OE1 . GLU B 2 39  ? 185.880 277.604 66.289 1.00 101.02 ? 39  GLU B OE1 1 
ATOM 1740 O OE2 . GLU B 2 39  ? 183.727 277.215 66.640 1.00 105.50 ? 39  GLU B OE2 1 
ATOM 1741 N N   . ILE B 2 40  ? 186.005 280.001 61.723 1.00 99.42  ? 40  ILE B N   1 
ATOM 1742 C CA  . ILE B 2 40  ? 185.795 281.430 61.519 1.00 100.48 ? 40  ILE B CA  1 
ATOM 1743 C C   . ILE B 2 40  ? 185.002 281.653 60.236 1.00 102.74 ? 40  ILE B C   1 
ATOM 1744 O O   . ILE B 2 40  ? 184.098 282.485 60.213 1.00 104.44 ? 40  ILE B O   1 
ATOM 1745 C CB  . ILE B 2 40  ? 187.118 282.222 61.460 1.00 101.27 ? 40  ILE B CB  1 
ATOM 1746 C CG1 . ILE B 2 40  ? 187.943 282.103 62.742 1.00 98.52  ? 40  ILE B CG1 1 
ATOM 1747 C CG2 . ILE B 2 40  ? 186.876 283.690 61.084 1.00 103.20 ? 40  ILE B CG2 1 
ATOM 1748 C CD1 . ILE B 2 40  ? 187.205 282.449 64.014 1.00 97.02  ? 40  ILE B CD1 1 
ATOM 1749 N N   . ALA B 2 41  ? 185.383 280.944 59.170 1.00 101.89 ? 41  ALA B N   1 
ATOM 1750 C CA  . ALA B 2 41  ? 184.762 281.116 57.869 1.00 103.48 ? 41  ALA B CA  1 
ATOM 1751 C C   . ALA B 2 41  ? 183.283 280.743 57.940 1.00 105.66 ? 41  ALA B C   1 
ATOM 1752 O O   . ALA B 2 41  ? 182.452 281.416 57.336 1.00 107.42 ? 41  ALA B O   1 
ATOM 1753 C CB  . ALA B 2 41  ? 185.498 280.285 56.844 1.00 108.25 ? 41  ALA B CB  1 
ATOM 1754 N N   . ASP B 2 42  ? 182.967 279.695 58.714 1.00 105.29 ? 42  ASP B N   1 
ATOM 1755 C CA  . ASP B 2 42  ? 181.610 279.193 58.868 1.00 104.99 ? 42  ASP B CA  1 
ATOM 1756 C C   . ASP B 2 42  ? 180.754 280.111 59.740 1.00 105.44 ? 42  ASP B C   1 
ATOM 1757 O O   . ASP B 2 42  ? 179.533 280.045 59.652 1.00 108.15 ? 42  ASP B O   1 
ATOM 1758 C CB  . ASP B 2 42  ? 181.602 277.787 59.446 1.00 105.59 ? 42  ASP B CB  1 
ATOM 1759 C CG  . ASP B 2 42  ? 182.346 276.742 58.626 1.00 108.78 ? 42  ASP B CG  1 
ATOM 1760 O OD1 . ASP B 2 42  ? 182.763 277.075 57.498 1.00 108.98 ? 42  ASP B OD1 1 
ATOM 1761 O OD2 . ASP B 2 42  ? 182.520 275.606 59.126 1.00 109.56 ? 42  ASP B OD2 1 
ATOM 1762 N N   . TYR B 2 43  ? 181.367 280.907 60.621 1.00 104.64 ? 43  TYR B N   1 
ATOM 1763 C CA  . TYR B 2 43  ? 180.642 281.928 61.363 1.00 104.90 ? 43  TYR B CA  1 
ATOM 1764 C C   . TYR B 2 43  ? 180.383 283.114 60.439 1.00 106.59 ? 43  TYR B C   1 
ATOM 1765 O O   . TYR B 2 43  ? 179.312 283.707 60.495 1.00 107.83 ? 43  TYR B O   1 
ATOM 1766 C CB  . TYR B 2 43  ? 181.355 282.457 62.614 1.00 104.62 ? 43  TYR B CB  1 
ATOM 1767 C CG  . TYR B 2 43  ? 181.343 281.529 63.821 1.00 104.30 ? 43  TYR B CG  1 
ATOM 1768 C CD1 . TYR B 2 43  ? 180.186 281.328 64.566 1.00 104.76 ? 43  TYR B CD1 1 
ATOM 1769 C CD2 . TYR B 2 43  ? 182.500 280.883 64.239 1.00 103.51 ? 43  TYR B CD2 1 
ATOM 1770 C CE1 . TYR B 2 43  ? 180.170 280.486 65.667 1.00 104.27 ? 43  TYR B CE1 1 
ATOM 1771 C CE2 . TYR B 2 43  ? 182.499 280.041 65.337 1.00 103.06 ? 43  TYR B CE2 1 
ATOM 1772 C CZ  . TYR B 2 43  ? 181.332 279.836 66.052 1.00 105.07 ? 43  TYR B CZ  1 
ATOM 1773 O OH  . TYR B 2 43  ? 181.365 278.993 67.129 1.00 103.23 ? 43  TYR B OH  1 
ATOM 1774 N N   . LEU B 2 44  ? 181.378 283.471 59.617 1.00 106.66 ? 44  LEU B N   1 
ATOM 1775 C CA  . LEU B 2 44  ? 181.234 284.566 58.674 1.00 107.52 ? 44  LEU B CA  1 
ATOM 1776 C C   . LEU B 2 44  ? 180.229 284.201 57.582 1.00 109.26 ? 44  LEU B C   1 
ATOM 1777 O O   . LEU B 2 44  ? 179.447 285.054 57.165 1.00 109.20 ? 44  LEU B O   1 
ATOM 1778 C CB  . LEU B 2 44  ? 182.592 284.938 58.079 1.00 108.13 ? 44  LEU B CB  1 
ATOM 1779 C CG  . LEU B 2 44  ? 183.565 285.689 58.995 1.00 107.02 ? 44  LEU B CG  1 
ATOM 1780 C CD1 . LEU B 2 44  ? 184.829 286.002 58.224 1.00 106.71 ? 44  LEU B CD1 1 
ATOM 1781 C CD2 . LEU B 2 44  ? 182.998 286.973 59.591 1.00 110.52 ? 44  LEU B CD2 1 
ATOM 1782 N N   . ALA B 2 45  ? 180.248 282.937 57.130 1.00 108.95 ? 45  ALA B N   1 
ATOM 1783 C CA  . ALA B 2 45  ? 179.371 282.488 56.058 1.00 110.24 ? 45  ALA B CA  1 
ATOM 1784 C C   . ALA B 2 45  ? 177.912 282.543 56.503 1.00 109.74 ? 45  ALA B C   1 
ATOM 1785 O O   . ALA B 2 45  ? 177.011 282.493 55.663 1.00 112.30 ? 45  ALA B O   1 
ATOM 1786 C CB  . ALA B 2 45  ? 179.755 281.088 55.603 1.00 110.40 ? 45  ALA B CB  1 
ATOM 1787 N N   . ALA B 2 46  ? 177.690 282.641 57.819 1.00 108.55 ? 46  ALA B N   1 
ATOM 1788 C CA  . ALA B 2 46  ? 176.350 282.702 58.374 1.00 109.34 ? 46  ALA B CA  1 
ATOM 1789 C C   . ALA B 2 46  ? 176.189 283.915 59.292 1.00 106.24 ? 46  ALA B C   1 
ATOM 1790 O O   . ALA B 2 46  ? 175.420 283.871 60.247 1.00 108.07 ? 46  ALA B O   1 
ATOM 1791 C CB  . ALA B 2 46  ? 176.069 281.393 59.081 1.00 109.87 ? 46  ALA B CB  1 
ATOM 1792 N N   . GLY B 2 47  ? 176.939 284.986 59.003 1.00 107.54 ? 47  GLY B N   1 
ATOM 1793 C CA  . GLY B 2 47  ? 176.618 286.329 59.461 1.00 107.89 ? 47  GLY B CA  1 
ATOM 1794 C C   . GLY B 2 47  ? 176.856 286.572 60.952 1.00 107.65 ? 47  GLY B C   1 
ATOM 1795 O O   . GLY B 2 47  ? 176.409 287.596 61.478 1.00 106.92 ? 47  GLY B O   1 
ATOM 1796 N N   . LYS B 2 48  ? 177.587 285.663 61.619 1.00 108.28 ? 48  LYS B N   1 
ATOM 1797 C CA  . LYS B 2 48  ? 177.882 285.790 63.042 1.00 108.12 ? 48  LYS B CA  1 
ATOM 1798 C C   . LYS B 2 48  ? 179.173 286.583 63.243 1.00 106.16 ? 48  LYS B C   1 
ATOM 1799 O O   . LYS B 2 48  ? 180.057 286.152 63.973 1.00 104.68 ? 48  LYS B O   1 
ATOM 1800 C CB  . LYS B 2 48  ? 177.995 284.403 63.685 1.00 108.35 ? 48  LYS B CB  1 
ATOM 1801 C CG  . LYS B 2 48  ? 176.814 283.464 63.504 1.00 108.79 ? 48  LYS B CG  1 
ATOM 1802 C CD  . LYS B 2 48  ? 175.508 284.001 64.071 1.00 110.54 ? 48  LYS B CD  1 
ATOM 1803 C CE  . LYS B 2 48  ? 174.435 282.960 64.145 1.00 113.29 ? 48  LYS B CE  1 
ATOM 1804 N NZ  . LYS B 2 48  ? 174.701 281.931 65.161 1.00 112.93 ? 48  LYS B NZ  1 
ATOM 1805 N N   . ASP B 2 49  ? 179.256 287.766 62.628 1.00 107.27 ? 49  ASP B N   1 
ATOM 1806 C CA  . ASP B 2 49  ? 180.501 288.509 62.522 1.00 107.91 ? 49  ASP B CA  1 
ATOM 1807 C C   . ASP B 2 49  ? 180.990 288.940 63.906 1.00 106.99 ? 49  ASP B C   1 
ATOM 1808 O O   . ASP B 2 49  ? 182.187 288.930 64.175 1.00 104.62 ? 49  ASP B O   1 
ATOM 1809 C CB  . ASP B 2 49  ? 180.342 289.675 61.557 1.00 109.05 ? 49  ASP B CB  1 
ATOM 1810 C CG  . ASP B 2 49  ? 179.513 290.848 62.066 1.00 112.43 ? 49  ASP B CG  1 
ATOM 1811 O OD1 . ASP B 2 49  ? 178.440 290.604 62.675 1.00 111.38 ? 49  ASP B OD1 1 
ATOM 1812 O OD2 . ASP B 2 49  ? 179.938 292.007 61.842 1.00 114.52 ? 49  ASP B OD2 1 
ATOM 1813 N N   . GLU B 2 50  ? 180.055 289.285 64.791 1.00 108.07 ? 50  GLU B N   1 
ATOM 1814 C CA  . GLU B 2 50  ? 180.383 289.773 66.121 1.00 108.29 ? 50  GLU B CA  1 
ATOM 1815 C C   . GLU B 2 50  ? 180.957 288.643 66.977 1.00 104.47 ? 50  GLU B C   1 
ATOM 1816 O O   . GLU B 2 50  ? 181.724 288.911 67.903 1.00 104.61 ? 50  GLU B O   1 
ATOM 1817 C CB  . GLU B 2 50  ? 179.124 290.420 66.705 1.00 108.90 ? 50  GLU B CB  1 
ATOM 1818 C CG  . GLU B 2 50  ? 179.351 291.226 67.982 1.00 110.54 ? 50  GLU B CG  1 
ATOM 1819 C CD  . GLU B 2 50  ? 180.170 292.513 67.877 1.00 115.16 ? 50  GLU B CD  1 
ATOM 1820 O OE1 . GLU B 2 50  ? 180.846 292.787 66.844 1.00 114.77 ? 50  GLU B OE1 1 
ATOM 1821 O OE2 . GLU B 2 50  ? 180.105 293.280 68.876 1.00 114.66 ? 50  GLU B OE2 1 
ATOM 1822 N N   . ARG B 2 51  ? 180.605 287.388 66.667 1.00 103.27 ? 51  ARG B N   1 
ATOM 1823 C CA  . ARG B 2 51  ? 181.225 286.255 67.332 1.00 100.40 ? 51  ARG B CA  1 
ATOM 1824 C C   . ARG B 2 51  ? 182.529 285.879 66.637 1.00 100.63 ? 51  ARG B C   1 
ATOM 1825 O O   . ARG B 2 51  ? 183.469 285.462 67.304 1.00 98.87  ? 51  ARG B O   1 
ATOM 1826 C CB  . ARG B 2 51  ? 180.356 284.999 67.437 1.00 99.84  ? 51  ARG B CB  1 
ATOM 1827 C CG  . ARG B 2 51  ? 181.055 283.970 68.313 1.00 100.85 ? 51  ARG B CG  1 
ATOM 1828 C CD  . ARG B 2 51  ? 180.149 283.012 69.047 1.00 100.32 ? 51  ARG B CD  1 
ATOM 1829 N NE  . ARG B 2 51  ? 180.934 282.231 70.008 1.00 95.65  ? 51  ARG B NE  1 
ATOM 1830 C CZ  . ARG B 2 51  ? 180.970 280.905 70.085 1.00 98.93  ? 51  ARG B CZ  1 
ATOM 1831 N NH1 . ARG B 2 51  ? 181.752 280.317 70.979 1.00 98.43  ? 51  ARG B NH1 1 
ATOM 1832 N NH2 . ARG B 2 51  ? 180.217 280.150 69.291 1.00 103.55 ? 51  ARG B NH2 1 
ATOM 1833 N N   . ALA B 2 52  ? 182.600 286.015 65.310 1.00 102.15 ? 52  ALA B N   1 
ATOM 1834 C CA  . ALA B 2 52  ? 183.834 285.731 64.591 1.00 99.84  ? 52  ALA B CA  1 
ATOM 1835 C C   . ALA B 2 52  ? 184.971 286.601 65.130 1.00 98.20  ? 52  ALA B C   1 
ATOM 1836 O O   . ALA B 2 52  ? 186.097 286.136 65.225 1.00 97.61  ? 52  ALA B O   1 
ATOM 1837 C CB  . ALA B 2 52  ? 183.631 285.925 63.109 1.00 101.06 ? 52  ALA B CB  1 
ATOM 1838 N N   . ARG B 2 53  ? 184.670 287.853 65.491 1.00 99.47  ? 53  ARG B N   1 
ATOM 1839 C CA  . ARG B 2 53  ? 185.651 288.752 66.071 1.00 100.04 ? 53  ARG B CA  1 
ATOM 1840 C C   . ARG B 2 53  ? 186.268 288.148 67.330 1.00 96.92  ? 53  ARG B C   1 
ATOM 1841 O O   . ARG B 2 53  ? 187.482 288.198 67.498 1.00 98.06  ? 53  ARG B O   1 
ATOM 1842 C CB  . ARG B 2 53  ? 185.021 290.116 66.369 1.00 102.36 ? 53  ARG B CB  1 
ATOM 1843 C CG  . ARG B 2 53  ? 184.806 290.955 65.120 1.00 106.63 ? 53  ARG B CG  1 
ATOM 1844 C CD  . ARG B 2 53  ? 184.126 292.289 65.368 1.00 112.01 ? 53  ARG B CD  1 
ATOM 1845 N NE  . ARG B 2 53  ? 183.866 292.871 64.046 1.00 114.77 ? 53  ARG B NE  1 
ATOM 1846 C CZ  . ARG B 2 53  ? 182.689 292.916 63.427 1.00 116.53 ? 53  ARG B CZ  1 
ATOM 1847 N NH1 . ARG B 2 53  ? 182.662 293.053 62.110 1.00 118.24 ? 53  ARG B NH1 1 
ATOM 1848 N NH2 . ARG B 2 53  ? 181.551 292.724 64.086 1.00 112.53 ? 53  ARG B NH2 1 
ATOM 1849 N N   . ILE B 2 54  ? 185.441 287.591 68.213 1.00 97.05  ? 54  ILE B N   1 
ATOM 1850 C CA  . ILE B 2 54  ? 185.916 287.044 69.473 1.00 94.81  ? 54  ILE B CA  1 
ATOM 1851 C C   . ILE B 2 54  ? 186.599 285.702 69.233 1.00 94.08  ? 54  ILE B C   1 
ATOM 1852 O O   . ILE B 2 54  ? 187.579 285.374 69.892 1.00 94.82  ? 54  ILE B O   1 
ATOM 1853 C CB  . ILE B 2 54  ? 184.749 286.963 70.473 1.00 94.33  ? 54  ILE B CB  1 
ATOM 1854 C CG1 . ILE B 2 54  ? 184.512 288.361 71.035 1.00 95.65  ? 54  ILE B CG1 1 
ATOM 1855 C CG2 . ILE B 2 54  ? 184.973 285.922 71.574 1.00 93.99  ? 54  ILE B CG2 1 
ATOM 1856 C CD1 . ILE B 2 54  ? 183.203 288.549 71.763 1.00 97.99  ? 54  ILE B CD1 1 
ATOM 1857 N N   . ARG B 2 55  ? 186.107 284.943 68.266 1.00 94.72  ? 55  ARG B N   1 
ATOM 1858 C CA  . ARG B 2 55  ? 186.659 283.634 67.975 1.00 93.54  ? 55  ARG B CA  1 
ATOM 1859 C C   . ARG B 2 55  ? 188.046 283.763 67.346 1.00 92.90  ? 55  ARG B C   1 
ATOM 1860 O O   . ARG B 2 55  ? 188.858 282.855 67.463 1.00 93.77  ? 55  ARG B O   1 
ATOM 1861 C CB  . ARG B 2 55  ? 185.630 282.943 67.075 1.00 94.98  ? 55  ARG B CB  1 
ATOM 1862 C CG  . ARG B 2 55  ? 185.612 281.424 67.057 1.00 95.59  ? 55  ARG B CG  1 
ATOM 1863 C CD  . ARG B 2 55  ? 184.776 280.844 68.167 1.00 94.10  ? 55  ARG B CD  1 
ATOM 1864 N NE  . ARG B 2 55  ? 185.537 280.764 69.412 1.00 92.69  ? 55  ARG B NE  1 
ATOM 1865 C CZ  . ARG B 2 55  ? 186.135 279.667 69.849 1.00 94.48  ? 55  ARG B CZ  1 
ATOM 1866 N NH1 . ARG B 2 55  ? 186.794 279.693 70.991 1.00 93.31  ? 55  ARG B NH1 1 
ATOM 1867 N NH2 . ARG B 2 55  ? 186.082 278.539 69.159 1.00 99.26  ? 55  ARG B NH2 1 
ATOM 1868 N N   . VAL B 2 56  ? 188.314 284.893 66.681 1.00 95.33  ? 56  VAL B N   1 
ATOM 1869 C CA  . VAL B 2 56  ? 189.615 285.189 66.093 1.00 94.39  ? 56  VAL B CA  1 
ATOM 1870 C C   . VAL B 2 56  ? 190.635 285.525 67.183 1.00 93.58  ? 56  VAL B C   1 
ATOM 1871 O O   . VAL B 2 56  ? 191.816 285.233 67.016 1.00 94.15  ? 56  VAL B O   1 
ATOM 1872 C CB  . VAL B 2 56  ? 189.489 286.298 65.022 1.00 95.29  ? 56  VAL B CB  1 
ATOM 1873 C CG1 . VAL B 2 56  ? 190.812 286.770 64.427 1.00 98.03  ? 56  VAL B CG1 1 
ATOM 1874 C CG2 . VAL B 2 56  ? 188.565 285.850 63.896 1.00 99.39  ? 56  VAL B CG2 1 
ATOM 1875 N N   . GLU B 2 57  ? 190.206 286.115 68.299 1.00 92.84  ? 57  GLU B N   1 
ATOM 1876 C CA  . GLU B 2 57  ? 191.132 286.395 69.382 1.00 92.59  ? 57  GLU B CA  1 
ATOM 1877 C C   . GLU B 2 57  ? 191.788 285.123 69.936 1.00 92.04  ? 57  GLU B C   1 
ATOM 1878 O O   . GLU B 2 57  ? 192.924 285.184 70.394 1.00 92.86  ? 57  GLU B O   1 
ATOM 1879 C CB  . GLU B 2 57  ? 190.458 287.155 70.518 1.00 92.91  ? 57  GLU B CB  1 
ATOM 1880 C CG  . GLU B 2 57  ? 190.033 288.557 70.113 1.00 94.68  ? 57  GLU B CG  1 
ATOM 1881 C CD  . GLU B 2 57  ? 189.661 289.472 71.271 1.00 98.45  ? 57  GLU B CD  1 
ATOM 1882 O OE1 . GLU B 2 57  ? 190.141 289.275 72.416 1.00 100.52 ? 57  GLU B OE1 1 
ATOM 1883 O OE2 . GLU B 2 57  ? 188.848 290.391 71.011 1.00 99.08  ? 57  GLU B OE2 1 
ATOM 1884 N N   . HIS B 2 58  ? 191.090 283.987 69.933 1.00 90.63  ? 58  HIS B N   1 
ATOM 1885 C CA  . HIS B 2 58  ? 191.708 282.731 70.313 1.00 90.06  ? 58  HIS B CA  1 
ATOM 1886 C C   . HIS B 2 58  ? 192.803 282.344 69.322 1.00 90.07  ? 58  HIS B C   1 
ATOM 1887 O O   . HIS B 2 58  ? 193.825 281.805 69.726 1.00 91.34  ? 58  HIS B O   1 
ATOM 1888 C CB  . HIS B 2 58  ? 190.671 281.606 70.402 1.00 91.32  ? 58  HIS B CB  1 
ATOM 1889 C CG  . HIS B 2 58  ? 189.772 281.737 71.568 1.00 89.22  ? 58  HIS B CG  1 
ATOM 1890 N ND1 . HIS B 2 58  ? 188.590 282.439 71.529 1.00 92.04  ? 58  HIS B ND1 1 
ATOM 1891 C CD2 . HIS B 2 58  ? 189.900 281.281 72.813 1.00 90.47  ? 58  HIS B CD2 1 
ATOM 1892 C CE1 . HIS B 2 58  ? 188.025 282.386 72.725 1.00 91.41  ? 58  HIS B CE1 1 
ATOM 1893 N NE2 . HIS B 2 58  ? 188.804 281.687 73.521 1.00 90.21  ? 58  HIS B NE2 1 
ATOM 1894 N N   . ILE B 2 59  ? 192.574 282.574 68.027 1.00 91.76  ? 59  ILE B N   1 
ATOM 1895 C CA  . ILE B 2 59  ? 193.506 282.141 66.995 1.00 91.75  ? 59  ILE B CA  1 
ATOM 1896 C C   . ILE B 2 59  ? 194.743 283.031 67.024 1.00 89.98  ? 59  ILE B C   1 
ATOM 1897 O O   . ILE B 2 59  ? 195.842 282.530 66.838 1.00 92.25  ? 59  ILE B O   1 
ATOM 1898 C CB  . ILE B 2 59  ? 192.819 282.114 65.613 1.00 93.59  ? 59  ILE B CB  1 
ATOM 1899 C CG1 . ILE B 2 59  ? 191.772 281.008 65.564 1.00 93.99  ? 59  ILE B CG1 1 
ATOM 1900 C CG2 . ILE B 2 59  ? 193.811 281.961 64.459 1.00 96.55  ? 59  ILE B CG2 1 
ATOM 1901 C CD1 . ILE B 2 59  ? 190.946 281.009 64.290 1.00 97.00  ? 59  ILE B CD1 1 
ATOM 1902 N N   . ILE B 2 60  ? 194.572 284.331 67.280 1.00 92.54  ? 60  ILE B N   1 
ATOM 1903 C CA  . ILE B 2 60  ? 195.709 285.238 67.344 1.00 92.91  ? 60  ILE B CA  1 
ATOM 1904 C C   . ILE B 2 60  ? 196.611 284.841 68.516 1.00 90.82  ? 60  ILE B C   1 
ATOM 1905 O O   . ILE B 2 60  ? 197.829 284.852 68.355 1.00 91.69  ? 60  ILE B O   1 
ATOM 1906 C CB  . ILE B 2 60  ? 195.264 286.713 67.405 1.00 94.50  ? 60  ILE B CB  1 
ATOM 1907 C CG1 . ILE B 2 60  ? 194.581 287.143 66.097 1.00 102.14 ? 60  ILE B CG1 1 
ATOM 1908 C CG2 . ILE B 2 60  ? 196.437 287.636 67.745 1.00 96.11  ? 60  ILE B CG2 1 
ATOM 1909 C CD1 . ILE B 2 60  ? 193.810 288.451 66.183 1.00 100.00 ? 60  ILE B CD1 1 
ATOM 1910 N N   . ARG B 2 61  ? 196.039 284.468 69.666 1.00 89.82  ? 61  ARG B N   1 
ATOM 1911 C CA  . ARG B 2 61  ? 196.844 284.005 70.781 1.00 87.55  ? 61  ARG B CA  1 
ATOM 1912 C C   . ARG B 2 61  ? 197.589 282.715 70.442 1.00 88.73  ? 61  ARG B C   1 
ATOM 1913 O O   . ARG B 2 61  ? 198.761 282.607 70.785 1.00 89.02  ? 61  ARG B O   1 
ATOM 1914 C CB  . ARG B 2 61  ? 196.102 283.791 72.103 1.00 89.85  ? 61  ARG B CB  1 
ATOM 1915 C CG  . ARG B 2 61  ? 196.054 285.070 72.922 1.00 96.33  ? 61  ARG B CG  1 
ATOM 1916 C CD  . ARG B 2 61  ? 195.793 284.903 74.419 1.00 97.46  ? 61  ARG B CD  1 
ATOM 1917 N NE  . ARG B 2 61  ? 195.642 286.223 75.052 1.00 98.74  ? 61  ARG B NE  1 
ATOM 1918 C CZ  . ARG B 2 61  ? 194.630 287.085 74.853 1.00 105.77 ? 61  ARG B CZ  1 
ATOM 1919 N NH1 . ARG B 2 61  ? 194.550 288.185 75.585 1.00 106.43 ? 61  ARG B NH1 1 
ATOM 1920 N NH2 . ARG B 2 61  ? 193.653 286.848 73.975 1.00 105.37 ? 61  ARG B NH2 1 
ATOM 1921 N N   . GLU B 2 62  ? 196.957 281.727 69.813 1.00 88.48  ? 62  GLU B N   1 
ATOM 1922 C CA  . GLU B 2 62  ? 197.667 280.487 69.539 1.00 88.46  ? 62  GLU B CA  1 
ATOM 1923 C C   . GLU B 2 62  ? 198.750 280.690 68.481 1.00 88.29  ? 62  GLU B C   1 
ATOM 1924 O O   . GLU B 2 62  ? 199.768 280.021 68.520 1.00 86.69  ? 62  GLU B O   1 
ATOM 1925 C CB  . GLU B 2 62  ? 196.744 279.356 69.096 1.00 90.72  ? 62  GLU B CB  1 
ATOM 1926 C CG  . GLU B 2 62  ? 195.834 278.871 70.217 1.00 92.89  ? 62  GLU B CG  1 
ATOM 1927 C CD  . GLU B 2 62  ? 196.583 278.264 71.391 1.00 94.17  ? 62  GLU B CD  1 
ATOM 1928 O OE1 . GLU B 2 62  ? 197.094 277.137 71.192 1.00 89.29  ? 62  GLU B OE1 1 
ATOM 1929 O OE2 . GLU B 2 62  ? 196.658 278.907 72.476 1.00 92.10  ? 62  GLU B OE2 1 
ATOM 1930 N N   . ASP B 2 63  ? 198.544 281.591 67.522 1.00 90.99  ? 63  ASP B N   1 
ATOM 1931 C CA  . ASP B 2 63  ? 199.564 281.878 66.525 1.00 91.80  ? 63  ASP B CA  1 
ATOM 1932 C C   . ASP B 2 63  ? 200.736 282.610 67.169 1.00 90.01  ? 63  ASP B C   1 
ATOM 1933 O O   . ASP B 2 63  ? 201.870 282.417 66.749 1.00 90.14  ? 63  ASP B O   1 
ATOM 1934 C CB  . ASP B 2 63  ? 199.002 282.658 65.350 1.00 98.38  ? 63  ASP B CB  1 
ATOM 1935 C CG  . ASP B 2 63  ? 198.068 281.886 64.422 1.00 99.88  ? 63  ASP B CG  1 
ATOM 1936 O OD1 . ASP B 2 63  ? 198.017 280.639 64.526 1.00 96.03  ? 63  ASP B OD1 1 
ATOM 1937 O OD2 . ASP B 2 63  ? 197.398 282.538 63.591 1.00 103.79 ? 63  ASP B OD2 1 
ATOM 1938 N N   . TYR B 2 64  ? 200.467 283.461 68.162 1.00 90.53  ? 64  TYR B N   1 
ATOM 1939 C CA  . TYR B 2 64  ? 201.540 284.100 68.904 1.00 88.83  ? 64  TYR B CA  1 
ATOM 1940 C C   . TYR B 2 64  ? 202.268 283.086 69.774 1.00 85.37  ? 64  TYR B C   1 
ATOM 1941 O O   . TYR B 2 64  ? 203.477 283.187 69.929 1.00 87.58  ? 64  TYR B O   1 
ATOM 1942 C CB  . TYR B 2 64  ? 201.069 285.230 69.822 1.00 90.05  ? 64  TYR B CB  1 
ATOM 1943 C CG  . TYR B 2 64  ? 200.821 286.579 69.168 1.00 91.82  ? 64  TYR B CG  1 
ATOM 1944 C CD1 . TYR B 2 64  ? 201.410 286.934 67.962 1.00 97.95  ? 64  TYR B CD1 1 
ATOM 1945 C CD2 . TYR B 2 64  ? 200.031 287.531 69.798 1.00 96.18  ? 64  TYR B CD2 1 
ATOM 1946 C CE1 . TYR B 2 64  ? 201.193 288.173 67.383 1.00 101.01 ? 64  TYR B CE1 1 
ATOM 1947 C CE2 . TYR B 2 64  ? 199.807 288.774 69.230 1.00 97.33  ? 64  TYR B CE2 1 
ATOM 1948 C CZ  . TYR B 2 64  ? 200.391 289.095 68.017 1.00 97.92  ? 64  TYR B CZ  1 
ATOM 1949 O OH  . TYR B 2 64  ? 200.204 290.306 67.421 1.00 103.28 ? 64  TYR B OH  1 
ATOM 1950 N N   . LEU B 2 65  ? 201.547 282.148 70.383 1.00 84.94  ? 65  LEU B N   1 
ATOM 1951 C CA  . LEU B 2 65  ? 202.171 281.223 71.312 1.00 82.03  ? 65  LEU B CA  1 
ATOM 1952 C C   . LEU B 2 65  ? 203.103 280.276 70.565 1.00 83.03  ? 65  LEU B C   1 
ATOM 1953 O O   . LEU B 2 65  ? 204.111 279.859 71.120 1.00 83.78  ? 65  LEU B O   1 
ATOM 1954 C CB  . LEU B 2 65  ? 201.109 280.450 72.085 1.00 82.96  ? 65  LEU B CB  1 
ATOM 1955 C CG  . LEU B 2 65  ? 201.597 279.369 73.051 1.00 81.89  ? 65  LEU B CG  1 
ATOM 1956 C CD1 . LEU B 2 65  ? 202.369 279.956 74.218 1.00 83.80  ? 65  LEU B CD1 1 
ATOM 1957 C CD2 . LEU B 2 65  ? 200.435 278.543 73.556 1.00 85.48  ? 65  LEU B CD2 1 
ATOM 1958 N N   . VAL B 2 66  ? 202.780 279.927 69.318 1.00 83.64  ? 66  VAL B N   1 
ATOM 1959 C CA  . VAL B 2 66  ? 203.661 279.081 68.532 1.00 82.18  ? 66  VAL B CA  1 
ATOM 1960 C C   . VAL B 2 66  ? 204.945 279.849 68.233 1.00 82.34  ? 66  VAL B C   1 
ATOM 1961 O O   . VAL B 2 66  ? 206.020 279.273 68.284 1.00 84.97  ? 66  VAL B O   1 
ATOM 1962 C CB  . VAL B 2 66  ? 202.978 278.536 67.261 1.00 83.05  ? 66  VAL B CB  1 
ATOM 1963 C CG1 . VAL B 2 66  ? 203.946 278.171 66.143 1.00 82.03  ? 66  VAL B CG1 1 
ATOM 1964 C CG2 . VAL B 2 66  ? 202.102 277.333 67.596 1.00 82.58  ? 66  VAL B CG2 1 
ATOM 1965 N N   . GLU B 2 67  ? 204.844 281.147 67.972 1.00 83.51  ? 67  GLU B N   1 
ATOM 1966 C CA  . GLU B 2 67  ? 206.020 281.961 67.726 1.00 86.27  ? 67  GLU B CA  1 
ATOM 1967 C C   . GLU B 2 67  ? 206.867 282.090 68.993 1.00 84.91  ? 67  GLU B C   1 
ATOM 1968 O O   . GLU B 2 67  ? 208.094 282.118 68.923 1.00 86.22  ? 67  GLU B O   1 
ATOM 1969 C CB  . GLU B 2 67  ? 205.605 283.331 67.197 1.00 90.28  ? 67  GLU B CB  1 
ATOM 1970 C CG  . GLU B 2 67  ? 205.050 283.283 65.775 1.00 91.08  ? 67  GLU B CG  1 
ATOM 1971 C CD  . GLU B 2 67  ? 204.509 284.616 65.278 1.00 100.92 ? 67  GLU B CD  1 
ATOM 1972 O OE1 . GLU B 2 67  ? 204.397 285.556 66.105 1.00 100.94 ? 67  GLU B OE1 1 
ATOM 1973 O OE2 . GLU B 2 67  ? 204.211 284.728 64.059 1.00 106.58 ? 67  GLU B OE2 1 
ATOM 1974 N N   . ALA B 2 68  ? 206.208 282.173 70.144 1.00 83.56  ? 68  ALA B N   1 
ATOM 1975 C CA  . ALA B 2 68  ? 206.907 282.208 71.414 1.00 84.24  ? 68  ALA B CA  1 
ATOM 1976 C C   . ALA B 2 68  ? 207.620 280.882 71.697 1.00 84.36  ? 68  ALA B C   1 
ATOM 1977 O O   . ALA B 2 68  ? 208.640 280.866 72.374 1.00 85.19  ? 68  ALA B O   1 
ATOM 1978 C CB  . ALA B 2 68  ? 205.932 282.537 72.515 1.00 84.68  ? 68  ALA B CB  1 
ATOM 1979 N N   . MET B 2 69  ? 207.051 279.762 71.255 1.00 83.47  ? 69  MET B N   1 
ATOM 1980 C CA  . MET B 2 69  ? 207.631 278.461 71.525 1.00 83.29  ? 69  MET B CA  1 
ATOM 1981 C C   . MET B 2 69  ? 208.847 278.286 70.625 1.00 85.13  ? 69  MET B C   1 
ATOM 1982 O O   . MET B 2 69  ? 209.871 277.768 71.049 1.00 84.39  ? 69  MET B O   1 
ATOM 1983 C CB  . MET B 2 69  ? 206.609 277.343 71.286 1.00 83.12  ? 69  MET B CB  1 
ATOM 1984 C CG  . MET B 2 69  ? 205.579 277.217 72.380 1.00 81.04  ? 69  MET B CG  1 
ATOM 1985 S SD  . MET B 2 69  ? 204.395 275.900 72.036 1.00 83.27  ? 69  MET B SD  1 
ATOM 1986 C CE  . MET B 2 69  ? 203.587 275.879 73.647 1.00 85.78  ? 69  MET B CE  1 
ATOM 1987 N N   . GLU B 2 70  ? 208.724 278.758 69.385 1.00 86.64  ? 70  GLU B N   1 
ATOM 1988 C CA  . GLU B 2 70  ? 209.819 278.756 68.435 1.00 86.56  ? 70  GLU B CA  1 
ATOM 1989 C C   . GLU B 2 70  ? 210.999 279.575 68.964 1.00 85.98  ? 70  GLU B C   1 
ATOM 1990 O O   . GLU B 2 70  ? 212.137 279.259 68.643 1.00 87.84  ? 70  GLU B O   1 
ATOM 1991 C CB  . GLU B 2 70  ? 209.270 279.271 67.106 1.00 91.59  ? 70  GLU B CB  1 
ATOM 1992 C CG  . GLU B 2 70  ? 210.248 279.142 65.940 1.00 97.56  ? 70  GLU B CG  1 
ATOM 1993 C CD  . GLU B 2 70  ? 209.653 279.382 64.553 1.00 104.57 ? 70  GLU B CD  1 
ATOM 1994 O OE1 . GLU B 2 70  ? 208.533 278.853 64.307 1.00 105.98 ? 70  GLU B OE1 1 
ATOM 1995 O OE2 . GLU B 2 70  ? 210.310 280.070 63.720 1.00 101.93 ? 70  GLU B OE2 1 
ATOM 1996 N N   . ILE B 2 71  ? 210.742 280.633 69.746 1.00 86.61  ? 71  ILE B N   1 
ATOM 1997 C CA  . ILE B 2 71  ? 211.801 281.447 70.324 1.00 84.53  ? 71  ILE B CA  1 
ATOM 1998 C C   . ILE B 2 71  ? 212.463 280.695 71.475 1.00 84.18  ? 71  ILE B C   1 
ATOM 1999 O O   . ILE B 2 71  ? 213.682 280.696 71.581 1.00 86.45  ? 71  ILE B O   1 
ATOM 2000 C CB  . ILE B 2 71  ? 211.275 282.818 70.779 1.00 85.05  ? 71  ILE B CB  1 
ATOM 2001 C CG1 . ILE B 2 71  ? 210.979 283.736 69.586 1.00 89.81  ? 71  ILE B CG1 1 
ATOM 2002 C CG2 . ILE B 2 71  ? 212.246 283.473 71.761 1.00 87.14  ? 71  ILE B CG2 1 
ATOM 2003 C CD1 . ILE B 2 71  ? 210.173 284.980 69.933 1.00 93.77  ? 71  ILE B CD1 1 
ATOM 2004 N N   . LEU B 2 72  ? 211.680 280.073 72.345 1.00 83.93  ? 72  LEU B N   1 
ATOM 2005 C CA  . LEU B 2 72  ? 212.225 279.411 73.517 1.00 83.11  ? 72  LEU B CA  1 
ATOM 2006 C C   . LEU B 2 72  ? 212.974 278.137 73.141 1.00 83.19  ? 72  LEU B C   1 
ATOM 2007 O O   . LEU B 2 72  ? 213.897 277.752 73.844 1.00 83.74  ? 72  LEU B O   1 
ATOM 2008 C CB  . LEU B 2 72  ? 211.097 279.090 74.496 1.00 84.32  ? 72  LEU B CB  1 
ATOM 2009 C CG  . LEU B 2 72  ? 210.433 280.286 75.183 1.00 84.54  ? 72  LEU B CG  1 
ATOM 2010 C CD1 . LEU B 2 72  ? 209.141 279.819 75.849 1.00 86.96  ? 72  LEU B CD1 1 
ATOM 2011 C CD2 . LEU B 2 72  ? 211.347 280.966 76.194 1.00 85.20  ? 72  LEU B CD2 1 
ATOM 2012 N N   . GLU B 2 73  ? 212.545 277.452 72.079 1.00 85.20  ? 73  GLU B N   1 
ATOM 2013 C CA  . GLU B 2 73  ? 213.215 276.257 71.583 1.00 84.43  ? 73  GLU B CA  1 
ATOM 2014 C C   . GLU B 2 73  ? 214.608 276.636 71.091 1.00 84.03  ? 73  GLU B C   1 
ATOM 2015 O O   . GLU B 2 73  ? 215.549 275.891 71.305 1.00 84.14  ? 73  GLU B O   1 
ATOM 2016 C CB  . GLU B 2 73  ? 212.278 275.620 70.556 1.00 86.46  ? 73  GLU B CB  1 
ATOM 2017 C CG  . GLU B 2 73  ? 212.814 274.414 69.797 1.00 89.61  ? 73  GLU B CG  1 
ATOM 2018 C CD  . GLU B 2 73  ? 213.636 274.845 68.590 1.00 95.61  ? 73  GLU B CD  1 
ATOM 2019 O OE1 . GLU B 2 73  ? 213.115 275.665 67.771 1.00 92.80  ? 73  GLU B OE1 1 
ATOM 2020 O OE2 . GLU B 2 73  ? 214.802 274.359 68.474 1.00 92.71  ? 73  GLU B OE2 1 
ATOM 2021 N N   . LEU B 2 74  ? 214.750 277.824 70.507 1.00 85.96  ? 74  LEU B N   1 
ATOM 2022 C CA  . LEU B 2 74  ? 216.044 278.341 70.085 1.00 84.94  ? 74  LEU B CA  1 
ATOM 2023 C C   . LEU B 2 74  ? 216.941 278.643 71.285 1.00 83.15  ? 74  LEU B C   1 
ATOM 2024 O O   . LEU B 2 74  ? 218.139 278.404 71.213 1.00 83.47  ? 74  LEU B O   1 
ATOM 2025 C CB  . LEU B 2 74  ? 215.811 279.580 69.220 1.00 84.85  ? 74  LEU B CB  1 
ATOM 2026 C CG  . LEU B 2 74  ? 217.055 280.294 68.678 1.00 85.51  ? 74  LEU B CG  1 
ATOM 2027 C CD1 . LEU B 2 74  ? 216.820 280.863 67.281 1.00 90.10  ? 74  LEU B CD1 1 
ATOM 2028 C CD2 . LEU B 2 74  ? 217.514 281.413 69.599 1.00 86.74  ? 74  LEU B CD2 1 
ATOM 2029 N N   . TYR B 2 75  ? 216.390 279.206 72.361 1.00 83.81  ? 75  TYR B N   1 
ATOM 2030 C CA  . TYR B 2 75  ? 217.198 279.569 73.513 1.00 83.55  ? 75  TYR B CA  1 
ATOM 2031 C C   . TYR B 2 75  ? 217.638 278.320 74.273 1.00 82.17  ? 75  TYR B C   1 
ATOM 2032 O O   . TYR B 2 75  ? 218.714 278.313 74.861 1.00 82.57  ? 75  TYR B O   1 
ATOM 2033 C CB  . TYR B 2 75  ? 216.485 280.528 74.469 1.00 85.02  ? 75  TYR B CB  1 
ATOM 2034 C CG  . TYR B 2 75  ? 216.316 281.936 73.923 1.00 86.49  ? 75  TYR B CG  1 
ATOM 2035 C CD1 . TYR B 2 75  ? 217.239 282.512 73.056 1.00 90.71  ? 75  TYR B CD1 1 
ATOM 2036 C CD2 . TYR B 2 75  ? 215.241 282.710 74.313 1.00 89.15  ? 75  TYR B CD2 1 
ATOM 2037 C CE1 . TYR B 2 75  ? 217.079 283.801 72.573 1.00 92.01  ? 75  TYR B CE1 1 
ATOM 2038 C CE2 . TYR B 2 75  ? 215.072 284.000 73.843 1.00 91.51  ? 75  TYR B CE2 1 
ATOM 2039 C CZ  . TYR B 2 75  ? 215.984 284.545 72.959 1.00 95.08  ? 75  TYR B CZ  1 
ATOM 2040 O OH  . TYR B 2 75  ? 215.815 285.815 72.482 1.00 98.09  ? 75  TYR B OH  1 
ATOM 2041 N N   . CYS B 2 76  ? 216.810 277.282 74.285 1.00 80.54  ? 76  CYS B N   1 
ATOM 2042 C CA  . CYS B 2 76  ? 217.226 276.022 74.856 1.00 79.83  ? 76  CYS B CA  1 
ATOM 2043 C C   . CYS B 2 76  ? 218.370 275.426 74.048 1.00 80.47  ? 76  CYS B C   1 
ATOM 2044 O O   . CYS B 2 76  ? 219.333 274.941 74.625 1.00 81.63  ? 76  CYS B O   1 
ATOM 2045 C CB  . CYS B 2 76  ? 216.071 275.035 74.889 1.00 81.55  ? 76  CYS B CB  1 
ATOM 2046 S SG  . CYS B 2 76  ? 214.888 275.394 76.207 1.00 81.38  ? 76  CYS B SG  1 
ATOM 2047 N N   . ASP B 2 77  ? 218.243 275.450 72.719 1.00 82.11  ? 77  ASP B N   1 
ATOM 2048 C CA  . ASP B 2 77  ? 219.239 274.886 71.820 1.00 82.58  ? 77  ASP B CA  1 
ATOM 2049 C C   . ASP B 2 77  ? 220.545 275.660 71.932 1.00 82.41  ? 77  ASP B C   1 
ATOM 2050 O O   . ASP B 2 77  ? 221.611 275.085 71.793 1.00 83.42  ? 77  ASP B O   1 
ATOM 2051 C CB  . ASP B 2 77  ? 218.731 274.878 70.391 1.00 81.34  ? 77  ASP B CB  1 
ATOM 2052 C CG  . ASP B 2 77  ? 219.438 273.919 69.450 1.00 85.64  ? 77  ASP B CG  1 
ATOM 2053 O OD1 . ASP B 2 77  ? 219.671 272.758 69.861 1.00 86.48  ? 77  ASP B OD1 1 
ATOM 2054 O OD2 . ASP B 2 77  ? 219.689 274.312 68.288 1.00 90.22  ? 77  ASP B OD2 1 
ATOM 2055 N N   . LEU B 2 78  ? 220.447 276.961 72.198 1.00 82.36  ? 78  LEU B N   1 
ATOM 2056 C CA  . LEU B 2 78  ? 221.606 277.799 72.415 1.00 82.68  ? 78  LEU B CA  1 
ATOM 2057 C C   . LEU B 2 78  ? 222.322 277.410 73.701 1.00 82.52  ? 78  LEU B C   1 
ATOM 2058 O O   . LEU B 2 78  ? 223.544 277.367 73.703 1.00 85.64  ? 78  LEU B O   1 
ATOM 2059 C CB  . LEU B 2 78  ? 221.177 279.261 72.464 1.00 83.90  ? 78  LEU B CB  1 
ATOM 2060 C CG  . LEU B 2 78  ? 222.301 280.290 72.606 1.00 85.02  ? 78  LEU B CG  1 
ATOM 2061 C CD1 . LEU B 2 78  ? 223.378 280.072 71.550 1.00 90.52  ? 78  LEU B CD1 1 
ATOM 2062 C CD2 . LEU B 2 78  ? 221.731 281.682 72.459 1.00 88.92  ? 78  LEU B CD2 1 
ATOM 2063 N N   . LEU B 2 79  ? 221.591 277.158 74.788 1.00 81.75  ? 79  LEU B N   1 
ATOM 2064 C CA  . LEU B 2 79  ? 222.236 276.778 76.033 1.00 79.49  ? 79  LEU B CA  1 
ATOM 2065 C C   . LEU B 2 79  ? 222.891 275.413 75.854 1.00 81.26  ? 79  LEU B C   1 
ATOM 2066 O O   . LEU B 2 79  ? 223.929 275.177 76.453 1.00 85.15  ? 79  LEU B O   1 
ATOM 2067 C CB  . LEU B 2 79  ? 221.318 276.737 77.252 1.00 80.51  ? 79  LEU B CB  1 
ATOM 2068 C CG  . LEU B 2 79  ? 220.690 278.059 77.708 1.00 82.41  ? 79  LEU B CG  1 
ATOM 2069 C CD1 . LEU B 2 79  ? 220.013 277.862 79.056 1.00 82.02  ? 79  LEU B CD1 1 
ATOM 2070 C CD2 . LEU B 2 79  ? 221.666 279.214 77.784 1.00 86.55  ? 79  LEU B CD2 1 
ATOM 2071 N N   . LEU B 2 80  ? 222.299 274.516 75.056 1.00 81.91  ? 80  LEU B N   1 
ATOM 2072 C CA  . LEU B 2 80  ? 222.864 273.189 74.842 1.00 80.13  ? 80  LEU B CA  1 
ATOM 2073 C C   . LEU B 2 80  ? 224.144 273.263 74.015 1.00 81.54  ? 80  LEU B C   1 
ATOM 2074 O O   . LEU B 2 80  ? 225.066 272.498 74.252 1.00 83.53  ? 80  LEU B O   1 
ATOM 2075 C CB  . LEU B 2 80  ? 221.849 272.269 74.180 1.00 78.67  ? 80  LEU B CB  1 
ATOM 2076 C CG  . LEU B 2 80  ? 220.779 271.670 75.096 1.00 79.61  ? 80  LEU B CG  1 
ATOM 2077 C CD1 . LEU B 2 80  ? 219.814 270.829 74.281 1.00 83.38  ? 80  LEU B CD1 1 
ATOM 2078 C CD2 . LEU B 2 80  ? 221.344 270.821 76.229 1.00 79.82  ? 80  LEU B CD2 1 
ATOM 2079 N N   . ALA B 2 81  ? 224.206 274.176 73.049 1.00 83.40  ? 81  ALA B N   1 
ATOM 2080 C CA  . ALA B 2 81  ? 225.398 274.353 72.233 1.00 84.62  ? 81  ALA B CA  1 
ATOM 2081 C C   . ALA B 2 81  ? 226.542 274.938 73.054 1.00 85.52  ? 81  ALA B C   1 
ATOM 2082 O O   . ALA B 2 81  ? 227.700 274.659 72.770 1.00 85.83  ? 81  ALA B O   1 
ATOM 2083 C CB  . ALA B 2 81  ? 225.087 275.255 71.061 1.00 85.98  ? 81  ALA B CB  1 
ATOM 2084 N N   . ARG B 2 82  ? 226.208 275.787 74.032 1.00 85.65  ? 82  ARG B N   1 
ATOM 2085 C CA  . ARG B 2 82  ? 227.199 276.500 74.818 1.00 86.18  ? 82  ARG B CA  1 
ATOM 2086 C C   . ARG B 2 82  ? 227.226 275.947 76.234 1.00 85.83  ? 82  ARG B C   1 
ATOM 2087 O O   . ARG B 2 82  ? 227.487 276.680 77.181 1.00 89.14  ? 82  ARG B O   1 
ATOM 2088 C CB  . ARG B 2 82  ? 226.844 277.984 74.902 1.00 87.93  ? 82  ARG B CB  1 
ATOM 2089 C CG  . ARG B 2 82  ? 226.949 278.779 73.610 1.00 89.97  ? 82  ARG B CG  1 
ATOM 2090 C CD  . ARG B 2 82  ? 226.458 280.173 73.916 1.00 96.32  ? 82  ARG B CD  1 
ATOM 2091 N NE  . ARG B 2 82  ? 226.467 281.053 72.746 1.00 97.40  ? 82  ARG B NE  1 
ATOM 2092 C CZ  . ARG B 2 82  ? 227.109 282.200 72.677 1.00 101.88 ? 82  ARG B CZ  1 
ATOM 2093 N NH1 . ARG B 2 82  ? 227.045 282.872 71.542 1.00 105.42 ? 82  ARG B NH1 1 
ATOM 2094 N NH2 . ARG B 2 82  ? 227.836 282.650 73.703 1.00 102.11 ? 82  ARG B NH2 1 
ATOM 2095 N N   . PHE B 2 83  ? 226.969 274.647 76.374 1.00 84.89  ? 83  PHE B N   1 
ATOM 2096 C CA  . PHE B 2 83  ? 226.812 274.054 77.690 1.00 85.65  ? 83  PHE B CA  1 
ATOM 2097 C C   . PHE B 2 83  ? 228.130 274.021 78.456 1.00 89.04  ? 83  PHE B C   1 
ATOM 2098 O O   . PHE B 2 83  ? 228.127 273.995 79.682 1.00 92.48  ? 83  PHE B O   1 
ATOM 2099 C CB  . PHE B 2 83  ? 226.281 272.628 77.585 1.00 85.17  ? 83  PHE B CB  1 
ATOM 2100 C CG  . PHE B 2 83  ? 225.572 272.213 78.858 1.00 84.37  ? 83  PHE B CG  1 
ATOM 2101 C CD1 . PHE B 2 83  ? 224.327 272.748 79.175 1.00 86.39  ? 83  PHE B CD1 1 
ATOM 2102 C CD2 . PHE B 2 83  ? 226.152 271.319 79.738 1.00 86.79  ? 83  PHE B CD2 1 
ATOM 2103 C CE1 . PHE B 2 83  ? 223.680 272.381 80.342 1.00 86.79  ? 83  PHE B CE1 1 
ATOM 2104 C CE2 . PHE B 2 83  ? 225.491 270.934 80.888 1.00 87.05  ? 83  PHE B CE2 1 
ATOM 2105 C CZ  . PHE B 2 83  ? 224.261 271.469 81.193 1.00 85.29  ? 83  PHE B CZ  1 
ATOM 2106 N N   . GLY B 2 84  ? 229.247 273.998 77.715 1.00 91.47  ? 84  GLY B N   1 
ATOM 2107 C CA  . GLY B 2 84  ? 230.583 274.054 78.281 1.00 91.64  ? 84  GLY B CA  1 
ATOM 2108 C C   . GLY B 2 84  ? 230.863 275.358 79.024 1.00 94.45  ? 84  GLY B C   1 
ATOM 2109 O O   . GLY B 2 84  ? 231.634 275.336 79.978 1.00 97.72  ? 84  GLY B O   1 
ATOM 2110 N N   . LEU B 2 85  ? 230.282 276.481 78.573 1.00 92.68  ? 85  LEU B N   1 
ATOM 2111 C CA  . LEU B 2 85  ? 230.442 277.743 79.279 1.00 93.93  ? 85  LEU B CA  1 
ATOM 2112 C C   . LEU B 2 85  ? 229.679 277.677 80.593 1.00 95.94  ? 85  LEU B C   1 
ATOM 2113 O O   . LEU B 2 85  ? 230.139 278.216 81.592 1.00 100.46 ? 85  LEU B O   1 
ATOM 2114 C CB  . LEU B 2 85  ? 229.979 278.953 78.476 1.00 93.19  ? 85  LEU B CB  1 
ATOM 2115 C CG  . LEU B 2 85  ? 230.791 279.289 77.224 1.00 96.05  ? 85  LEU B CG  1 
ATOM 2116 C CD1 . LEU B 2 85  ? 230.042 280.283 76.342 1.00 101.19 ? 85  LEU B CD1 1 
ATOM 2117 C CD2 . LEU B 2 85  ? 232.174 279.833 77.573 1.00 97.81  ? 85  LEU B CD2 1 
ATOM 2118 N N   . ILE B 2 86  ? 228.506 277.048 80.582 1.00 94.10  ? 86  ILE B N   1 
ATOM 2119 C CA  . ILE B 2 86  ? 227.676 277.021 81.773 1.00 96.27  ? 86  ILE B CA  1 
ATOM 2120 C C   . ILE B 2 86  ? 228.442 276.307 82.882 1.00 98.42  ? 86  ILE B C   1 
ATOM 2121 O O   . ILE B 2 86  ? 228.497 276.820 83.999 1.00 100.36 ? 86  ILE B O   1 
ATOM 2122 C CB  . ILE B 2 86  ? 226.305 276.371 81.496 1.00 96.05  ? 86  ILE B CB  1 
ATOM 2123 C CG1 . ILE B 2 86  ? 225.461 277.267 80.579 1.00 97.31  ? 86  ILE B CG1 1 
ATOM 2124 C CG2 . ILE B 2 86  ? 225.570 276.018 82.793 1.00 96.09  ? 86  ILE B CG2 1 
ATOM 2125 C CD1 . ILE B 2 86  ? 224.226 276.595 80.002 1.00 96.04  ? 86  ILE B CD1 1 
ATOM 2126 N N   . GLN B 2 87  ? 229.039 275.146 82.570 1.00 97.66  ? 87  GLN B N   1 
ATOM 2127 C CA  . GLN B 2 87  ? 229.519 274.258 83.620 1.00 98.84  ? 87  GLN B CA  1 
ATOM 2128 C C   . GLN B 2 87  ? 231.035 274.406 83.804 1.00 101.86 ? 87  GLN B C   1 
ATOM 2129 O O   . GLN B 2 87  ? 231.643 273.606 84.515 1.00 102.70 ? 87  GLN B O   1 
ATOM 2130 C CB  . GLN B 2 87  ? 229.003 272.831 83.395 1.00 97.10  ? 87  GLN B CB  1 
ATOM 2131 C CG  . GLN B 2 87  ? 229.650 272.056 82.251 1.00 98.14  ? 87  GLN B CG  1 
ATOM 2132 C CD  . GLN B 2 87  ? 229.149 270.629 82.133 1.00 95.33  ? 87  GLN B CD  1 
ATOM 2133 O OE1 . GLN B 2 87  ? 229.127 270.044 81.041 1.00 94.39  ? 87  GLN B OE1 1 
ATOM 2134 N NE2 . GLN B 2 87  ? 228.797 270.020 83.259 1.00 96.16  ? 87  GLN B NE2 1 
ATOM 2135 N N   . SER B 2 88  ? 231.641 275.438 83.197 1.00 101.01 ? 88  SER B N   1 
ATOM 2136 C CA  . SER B 2 88  ? 233.011 275.818 83.514 1.00 102.83 ? 88  SER B CA  1 
ATOM 2137 C C   . SER B 2 88  ? 232.998 276.987 84.497 1.00 105.32 ? 88  SER B C   1 
ATOM 2138 O O   . SER B 2 88  ? 233.512 276.864 85.605 1.00 106.89 ? 88  SER B O   1 
ATOM 2139 C CB  . SER B 2 88  ? 233.823 276.148 82.277 1.00 102.61 ? 88  SER B CB  1 
ATOM 2140 O OG  . SER B 2 88  ? 233.298 277.265 81.573 1.00 99.57  ? 88  SER B OG  1 
ATOM 2141 N N   . MET B 2 89  ? 232.372 278.099 84.097 1.00 105.03 ? 89  MET B N   1 
ATOM 2142 C CA  . MET B 2 89  ? 232.375 279.331 84.872 1.00 108.62 ? 89  MET B CA  1 
ATOM 2143 C C   . MET B 2 89  ? 231.411 279.230 86.055 1.00 110.46 ? 89  MET B C   1 
ATOM 2144 O O   . MET B 2 89  ? 230.540 278.366 86.072 1.00 108.37 ? 89  MET B O   1 
ATOM 2145 C CB  . MET B 2 89  ? 231.942 280.498 83.981 1.00 109.07 ? 89  MET B CB  1 
ATOM 2146 C CG  . MET B 2 89  ? 232.865 280.754 82.811 1.00 108.02 ? 89  MET B CG  1 
ATOM 2147 S SD  . MET B 2 89  ? 232.037 281.577 81.435 1.00 115.22 ? 89  MET B SD  1 
ATOM 2148 C CE  . MET B 2 89  ? 231.549 283.172 82.110 1.00 112.20 ? 89  MET B CE  1 
ATOM 2149 N N   . LYS B 2 90  ? 231.586 280.109 87.052 1.00 112.80 ? 90  LYS B N   1 
ATOM 2150 C CA  . LYS B 2 90  ? 230.551 280.386 88.041 1.00 114.10 ? 90  LYS B CA  1 
ATOM 2151 C C   . LYS B 2 90  ? 229.816 281.671 87.657 1.00 114.26 ? 90  LYS B C   1 
ATOM 2152 O O   . LYS B 2 90  ? 228.775 281.997 88.228 1.00 114.37 ? 90  LYS B O   1 
ATOM 2153 C CB  . LYS B 2 90  ? 231.112 280.521 89.463 1.00 117.03 ? 90  LYS B CB  1 
ATOM 2154 C CG  . LYS B 2 90  ? 232.065 281.696 89.690 1.00 118.52 ? 90  LYS B CG  1 
ATOM 2155 C CD  . LYS B 2 90  ? 232.866 281.633 90.992 1.00 122.33 ? 90  LYS B CD  1 
ATOM 2156 C CE  . LYS B 2 90  ? 233.961 282.679 91.106 1.00 123.89 ? 90  LYS B CE  1 
ATOM 2157 N NZ  . LYS B 2 90  ? 235.023 282.578 90.090 1.00 123.32 ? 90  LYS B NZ  1 
ATOM 2158 N N   . GLU B 2 91  ? 230.381 282.392 86.684 1.00 114.35 ? 91  GLU B N   1 
ATOM 2159 C CA  . GLU B 2 91  ? 229.818 283.627 86.170 1.00 114.50 ? 91  GLU B CA  1 
ATOM 2160 C C   . GLU B 2 91  ? 228.805 283.282 85.082 1.00 113.14 ? 91  GLU B C   1 
ATOM 2161 O O   . GLU B 2 91  ? 228.764 282.139 84.622 1.00 111.79 ? 91  GLU B O   1 
ATOM 2162 C CB  . GLU B 2 91  ? 230.933 284.494 85.580 1.00 116.04 ? 91  GLU B CB  1 
ATOM 2163 C CG  . GLU B 2 91  ? 232.063 284.826 86.558 1.00 119.10 ? 91  GLU B CG  1 
ATOM 2164 C CD  . GLU B 2 91  ? 233.015 283.704 86.976 1.00 119.12 ? 91  GLU B CD  1 
ATOM 2165 O OE1 . GLU B 2 91  ? 232.990 282.573 86.418 1.00 114.94 ? 91  GLU B OE1 1 
ATOM 2166 O OE2 . GLU B 2 91  ? 233.803 283.989 87.912 1.00 120.71 ? 91  GLU B OE2 1 
ATOM 2167 N N   . LEU B 2 92  ? 228.006 284.272 84.664 1.00 110.75 ? 92  LEU B N   1 
ATOM 2168 C CA  . LEU B 2 92  ? 227.087 284.085 83.557 1.00 108.80 ? 92  LEU B CA  1 
ATOM 2169 C C   . LEU B 2 92  ? 227.660 284.770 82.318 1.00 108.07 ? 92  LEU B C   1 
ATOM 2170 O O   . LEU B 2 92  ? 227.855 285.985 82.323 1.00 108.11 ? 92  LEU B O   1 
ATOM 2171 C CB  . LEU B 2 92  ? 225.705 284.615 83.939 1.00 109.54 ? 92  LEU B CB  1 
ATOM 2172 C CG  . LEU B 2 92  ? 224.639 284.614 82.835 1.00 108.70 ? 92  LEU B CG  1 
ATOM 2173 C CD1 . LEU B 2 92  ? 224.434 283.236 82.213 1.00 105.86 ? 92  LEU B CD1 1 
ATOM 2174 C CD2 . LEU B 2 92  ? 223.325 285.172 83.369 1.00 108.47 ? 92  LEU B CD2 1 
ATOM 2175 N N   . ASP B 2 93  ? 227.901 283.972 81.265 1.00 108.53 ? 93  ASP B N   1 
ATOM 2176 C CA  . ASP B 2 93  ? 228.472 284.458 80.017 1.00 107.66 ? 93  ASP B CA  1 
ATOM 2177 C C   . ASP B 2 93  ? 227.598 285.586 79.475 1.00 107.25 ? 93  ASP B C   1 
ATOM 2178 O O   . ASP B 2 93  ? 226.395 285.612 79.726 1.00 106.10 ? 93  ASP B O   1 
ATOM 2179 C CB  . ASP B 2 93  ? 228.622 283.344 78.990 1.00 106.95 ? 93  ASP B CB  1 
ATOM 2180 C CG  . ASP B 2 93  ? 229.524 283.649 77.801 1.00 108.74 ? 93  ASP B CG  1 
ATOM 2181 O OD1 . ASP B 2 93  ? 230.754 283.754 78.024 1.00 109.03 ? 93  ASP B OD1 1 
ATOM 2182 O OD2 . ASP B 2 93  ? 228.998 283.780 76.663 1.00 106.14 ? 93  ASP B OD2 1 
ATOM 2183 N N   . SER B 2 94  ? 228.215 286.511 78.731 1.00 107.85 ? 94  SER B N   1 
ATOM 2184 C CA  . SER B 2 94  ? 227.491 287.630 78.146 1.00 108.36 ? 94  SER B CA  1 
ATOM 2185 C C   . SER B 2 94  ? 226.582 287.137 77.018 1.00 107.81 ? 94  SER B C   1 
ATOM 2186 O O   . SER B 2 94  ? 225.529 287.731 76.778 1.00 107.07 ? 94  SER B O   1 
ATOM 2187 C CB  . SER B 2 94  ? 228.437 288.710 77.654 1.00 109.74 ? 94  SER B CB  1 
ATOM 2188 O OG  . SER B 2 94  ? 229.214 288.262 76.547 1.00 110.61 ? 94  SER B OG  1 
ATOM 2189 N N   . GLY B 2 95  ? 227.001 286.057 76.336 1.00 106.56 ? 95  GLY B N   1 
ATOM 2190 C CA  . GLY B 2 95  ? 226.231 285.468 75.251 1.00 105.18 ? 95  GLY B CA  1 
ATOM 2191 C C   . GLY B 2 95  ? 225.237 284.428 75.763 1.00 103.38 ? 95  GLY B C   1 
ATOM 2192 O O   . GLY B 2 95  ? 224.655 283.692 74.972 1.00 102.32 ? 95  GLY B O   1 
ATOM 2193 N N   . LEU B 2 96  ? 225.056 284.370 77.085 1.00 102.37 ? 96  LEU B N   1 
ATOM 2194 C CA  . LEU B 2 96  ? 224.105 283.452 77.680 1.00 101.47 ? 96  LEU B CA  1 
ATOM 2195 C C   . LEU B 2 96  ? 222.980 284.190 78.404 1.00 101.05 ? 96  LEU B C   1 
ATOM 2196 O O   . LEU B 2 96  ? 221.941 283.592 78.671 1.00 97.64  ? 96  LEU B O   1 
ATOM 2197 C CB  . LEU B 2 96  ? 224.862 282.529 78.632 1.00 102.35 ? 96  LEU B CB  1 
ATOM 2198 C CG  . LEU B 2 96  ? 225.717 281.427 77.994 1.00 101.61 ? 96  LEU B CG  1 
ATOM 2199 C CD1 . LEU B 2 96  ? 226.319 280.565 79.101 1.00 102.38 ? 96  LEU B CD1 1 
ATOM 2200 C CD2 . LEU B 2 96  ? 224.959 280.553 77.024 1.00 98.43  ? 96  LEU B CD2 1 
ATOM 2201 N N   . ALA B 2 97  ? 223.168 285.480 78.705 1.00 101.95 ? 97  ALA B N   1 
ATOM 2202 C CA  . ALA B 2 97  ? 222.300 286.166 79.649 1.00 101.26 ? 97  ALA B CA  1 
ATOM 2203 C C   . ALA B 2 97  ? 220.892 286.336 79.088 1.00 99.32  ? 97  ALA B C   1 
ATOM 2204 O O   . ALA B 2 97  ? 219.927 286.260 79.846 1.00 99.60  ? 97  ALA B O   1 
ATOM 2205 C CB  . ALA B 2 97  ? 222.887 287.502 80.030 1.00 103.41 ? 97  ALA B CB  1 
ATOM 2206 N N   . GLU B 2 98  ? 220.772 286.577 77.777 1.00 100.24 ? 98  GLU B N   1 
ATOM 2207 C CA  . GLU B 2 98  ? 219.457 286.703 77.166 1.00 98.53  ? 98  GLU B CA  1 
ATOM 2208 C C   . GLU B 2 98  ? 218.694 285.393 77.338 1.00 95.67  ? 98  GLU B C   1 
ATOM 2209 O O   . GLU B 2 98  ? 217.585 285.401 77.852 1.00 97.15  ? 98  GLU B O   1 
ATOM 2210 C CB  . GLU B 2 98  ? 219.535 287.115 75.696 1.00 99.64  ? 98  GLU B CB  1 
ATOM 2211 C CG  . GLU B 2 98  ? 218.167 287.331 75.048 1.00 99.97  ? 98  GLU B CG  1 
ATOM 2212 C CD  . GLU B 2 98  ? 218.189 287.952 73.658 1.00 101.94 ? 98  GLU B CD  1 
ATOM 2213 O OE1 . GLU B 2 98  ? 219.278 288.343 73.180 1.00 105.50 ? 98  GLU B OE1 1 
ATOM 2214 O OE2 . GLU B 2 98  ? 217.106 288.059 73.043 1.00 101.04 ? 98  GLU B OE2 1 
ATOM 2215 N N   . SER B 2 99  ? 219.314 284.281 76.937 1.00 96.00  ? 99  SER B N   1 
ATOM 2216 C CA  . SER B 2 99  ? 218.702 282.968 77.020 1.00 93.59  ? 99  SER B CA  1 
ATOM 2217 C C   . SER B 2 99  ? 218.381 282.589 78.461 1.00 94.15  ? 99  SER B C   1 
ATOM 2218 O O   . SER B 2 99  ? 217.329 282.014 78.718 1.00 93.56  ? 99  SER B O   1 
ATOM 2219 C CB  . SER B 2 99  ? 219.583 281.939 76.395 1.00 91.82  ? 99  SER B CB  1 
ATOM 2220 O OG  . SER B 2 99  ? 219.947 282.361 75.090 1.00 91.50  ? 99  SER B OG  1 
ATOM 2221 N N   . VAL B 2 100 ? 219.282 282.882 79.396 1.00 94.98  ? 100 VAL B N   1 
ATOM 2222 C CA  . VAL B 2 100 ? 219.087 282.414 80.756 1.00 94.68  ? 100 VAL B CA  1 
ATOM 2223 C C   . VAL B 2 100 ? 217.965 283.221 81.408 1.00 97.14  ? 100 VAL B C   1 
ATOM 2224 O O   . VAL B 2 100 ? 217.075 282.636 82.028 1.00 96.19  ? 100 VAL B O   1 
ATOM 2225 C CB  . VAL B 2 100 ? 220.393 282.434 81.573 1.00 95.40  ? 100 VAL B CB  1 
ATOM 2226 C CG1 . VAL B 2 100 ? 220.149 282.246 83.068 1.00 98.70  ? 100 VAL B CG1 1 
ATOM 2227 C CG2 . VAL B 2 100 ? 221.370 281.377 81.068 1.00 95.26  ? 100 VAL B CG2 1 
ATOM 2228 N N   . SER B 2 101 ? 217.987 284.551 81.250 1.00 97.41  ? 101 SER B N   1 
ATOM 2229 C CA  . SER B 2 101 ? 216.968 285.385 81.866 1.00 97.94  ? 101 SER B CA  1 
ATOM 2230 C C   . SER B 2 101 ? 215.598 285.085 81.262 1.00 96.18  ? 101 SER B C   1 
ATOM 2231 O O   . SER B 2 101 ? 214.610 285.010 81.995 1.00 96.64  ? 101 SER B O   1 
ATOM 2232 C CB  . SER B 2 101 ? 217.306 286.842 81.756 1.00 100.48 ? 101 SER B CB  1 
ATOM 2233 O OG  . SER B 2 101 ? 217.479 287.221 80.400 1.00 101.43 ? 101 SER B OG  1 
ATOM 2234 N N   . THR B 2 102 ? 215.546 284.884 79.936 1.00 95.43  ? 102 THR B N   1 
ATOM 2235 C CA  . THR B 2 102 ? 214.283 284.713 79.228 1.00 92.81  ? 102 THR B CA  1 
ATOM 2236 C C   . THR B 2 102 ? 213.607 283.391 79.598 1.00 90.12  ? 102 THR B C   1 
ATOM 2237 O O   . THR B 2 102 ? 212.400 283.353 79.766 1.00 91.87  ? 102 THR B O   1 
ATOM 2238 C CB  . THR B 2 102 ? 214.510 284.826 77.726 1.00 92.40  ? 102 THR B CB  1 
ATOM 2239 O OG1 . THR B 2 102 ? 215.020 286.133 77.484 1.00 97.84  ? 102 THR B OG1 1 
ATOM 2240 C CG2 . THR B 2 102 ? 213.227 284.712 76.934 1.00 92.74  ? 102 THR B CG2 1 
ATOM 2241 N N   . LEU B 2 103 ? 214.368 282.312 79.743 1.00 91.66  ? 103 LEU B N   1 
ATOM 2242 C CA  . LEU B 2 103 ? 213.794 281.035 80.140 1.00 89.14  ? 103 LEU B CA  1 
ATOM 2243 C C   . LEU B 2 103 ? 213.282 281.101 81.579 1.00 89.96  ? 103 LEU B C   1 
ATOM 2244 O O   . LEU B 2 103 ? 212.321 280.416 81.906 1.00 90.46  ? 103 LEU B O   1 
ATOM 2245 C CB  . LEU B 2 103 ? 214.812 279.907 79.959 1.00 88.83  ? 103 LEU B CB  1 
ATOM 2246 C CG  . LEU B 2 103 ? 215.183 279.538 78.516 1.00 87.86  ? 103 LEU B CG  1 
ATOM 2247 C CD1 . LEU B 2 103 ? 216.490 278.774 78.455 1.00 88.44  ? 103 LEU B CD1 1 
ATOM 2248 C CD2 . LEU B 2 103 ? 214.105 278.715 77.849 1.00 86.83  ? 103 LEU B CD2 1 
ATOM 2249 N N   . ILE B 2 104 ? 213.914 281.900 82.447 1.00 93.50  ? 104 ILE B N   1 
ATOM 2250 C CA  . ILE B 2 104 ? 213.467 282.025 83.832 1.00 93.65  ? 104 ILE B CA  1 
ATOM 2251 C C   . ILE B 2 104 ? 212.158 282.818 83.875 1.00 94.41  ? 104 ILE B C   1 
ATOM 2252 O O   . ILE B 2 104 ? 211.264 282.487 84.653 1.00 94.83  ? 104 ILE B O   1 
ATOM 2253 C CB  . ILE B 2 104 ? 214.565 282.640 84.725 1.00 96.11  ? 104 ILE B CB  1 
ATOM 2254 C CG1 . ILE B 2 104 ? 215.743 281.671 84.897 1.00 96.86  ? 104 ILE B CG1 1 
ATOM 2255 C CG2 . ILE B 2 104 ? 214.004 283.067 86.081 1.00 100.18 ? 104 ILE B CG2 1 
ATOM 2256 C CD1 . ILE B 2 104 ? 217.015 282.285 85.458 1.00 100.67 ? 104 ILE B CD1 1 
ATOM 2257 N N   . TRP B 2 105 ? 212.047 283.843 83.025 1.00 93.36  ? 105 TRP B N   1 
ATOM 2258 C CA  . TRP B 2 105 ? 210.846 284.654 82.934 1.00 94.38  ? 105 TRP B CA  1 
ATOM 2259 C C   . TRP B 2 105 ? 209.670 283.862 82.363 1.00 93.91  ? 105 TRP B C   1 
ATOM 2260 O O   . TRP B 2 105 ? 208.538 284.074 82.787 1.00 95.41  ? 105 TRP B O   1 
ATOM 2261 C CB  . TRP B 2 105 ? 211.123 285.890 82.072 1.00 98.59  ? 105 TRP B CB  1 
ATOM 2262 C CG  . TRP B 2 105 ? 209.995 286.886 82.002 1.00 99.43  ? 105 TRP B CG  1 
ATOM 2263 C CD1 . TRP B 2 105 ? 209.818 287.975 82.799 1.00 103.92 ? 105 TRP B CD1 1 
ATOM 2264 C CD2 . TRP B 2 105 ? 208.904 286.905 81.059 1.00 99.38  ? 105 TRP B CD2 1 
ATOM 2265 N NE1 . TRP B 2 105 ? 208.702 288.668 82.421 1.00 102.79 ? 105 TRP B NE1 1 
ATOM 2266 C CE2 . TRP B 2 105 ? 208.120 288.035 81.360 1.00 100.72 ? 105 TRP B CE2 1 
ATOM 2267 C CE3 . TRP B 2 105 ? 208.512 286.083 79.999 1.00 98.68  ? 105 TRP B CE3 1 
ATOM 2268 C CZ2 . TRP B 2 105 ? 206.972 288.356 80.646 1.00 101.80 ? 105 TRP B CZ2 1 
ATOM 2269 C CZ3 . TRP B 2 105 ? 207.379 286.404 79.288 1.00 100.32 ? 105 TRP B CZ3 1 
ATOM 2270 C CH2 . TRP B 2 105 ? 206.622 287.526 79.608 1.00 100.93 ? 105 TRP B CH2 1 
ATOM 2271 N N   . ALA B 2 106 ? 209.920 282.990 81.379 1.00 92.31  ? 106 ALA B N   1 
ATOM 2272 C CA  . ALA B 2 106 ? 208.845 282.323 80.660 1.00 89.77  ? 106 ALA B CA  1 
ATOM 2273 C C   . ALA B 2 106 ? 208.315 281.113 81.429 1.00 89.12  ? 106 ALA B C   1 
ATOM 2274 O O   . ALA B 2 106 ? 207.150 280.773 81.297 1.00 90.97  ? 106 ALA B O   1 
ATOM 2275 C CB  . ALA B 2 106 ? 209.309 281.923 79.287 1.00 89.24  ? 106 ALA B CB  1 
ATOM 2276 N N   . ALA B 2 107 ? 209.139 280.482 82.255 1.00 88.88  ? 107 ALA B N   1 
ATOM 2277 C CA  . ALA B 2 107 ? 208.746 279.241 82.895 1.00 87.58  ? 107 ALA B CA  1 
ATOM 2278 C C   . ALA B 2 107 ? 207.415 279.361 83.634 1.00 90.67  ? 107 ALA B C   1 
ATOM 2279 O O   . ALA B 2 107 ? 206.588 278.462 83.499 1.00 92.91  ? 107 ALA B O   1 
ATOM 2280 C CB  . ALA B 2 107 ? 209.823 278.770 83.835 1.00 89.63  ? 107 ALA B CB  1 
ATOM 2281 N N   . PRO B 2 108 ? 207.146 280.386 84.480 1.00 91.99  ? 108 PRO B N   1 
ATOM 2282 C CA  . PRO B 2 108 ? 205.849 280.457 85.159 1.00 92.76  ? 108 PRO B CA  1 
ATOM 2283 C C   . PRO B 2 108 ? 204.658 280.624 84.218 1.00 91.74  ? 108 PRO B C   1 
ATOM 2284 O O   . PRO B 2 108 ? 203.574 280.147 84.538 1.00 93.75  ? 108 PRO B O   1 
ATOM 2285 C CB  . PRO B 2 108 ? 206.002 281.650 86.112 1.00 93.29  ? 108 PRO B CB  1 
ATOM 2286 C CG  . PRO B 2 108 ? 207.087 282.491 85.490 1.00 93.67  ? 108 PRO B CG  1 
ATOM 2287 C CD  . PRO B 2 108 ? 208.046 281.476 84.890 1.00 92.68  ? 108 PRO B CD  1 
ATOM 2288 N N   . ARG B 2 109 ? 204.867 281.269 83.061 1.00 91.78  ? 109 ARG B N   1 
ATOM 2289 C CA  . ARG B 2 109 ? 203.821 281.431 82.064 1.00 90.81  ? 109 ARG B CA  1 
ATOM 2290 C C   . ARG B 2 109 ? 203.511 280.125 81.327 1.00 91.95  ? 109 ARG B C   1 
ATOM 2291 O O   . ARG B 2 109 ? 202.352 279.872 81.015 1.00 93.54  ? 109 ARG B O   1 
ATOM 2292 C CB  . ARG B 2 109 ? 204.194 282.470 81.004 1.00 92.87  ? 109 ARG B CB  1 
ATOM 2293 C CG  . ARG B 2 109 ? 204.014 283.922 81.421 1.00 97.24  ? 109 ARG B CG  1 
ATOM 2294 C CD  . ARG B 2 109 ? 205.184 284.510 82.174 1.00 98.09  ? 109 ARG B CD  1 
ATOM 2295 N NE  . ARG B 2 109 ? 204.906 285.886 82.599 1.00 99.52  ? 109 ARG B NE  1 
ATOM 2296 C CZ  . ARG B 2 109 ? 205.650 286.599 83.449 1.00 102.28 ? 109 ARG B CZ  1 
ATOM 2297 N NH1 . ARG B 2 109 ? 205.203 287.770 83.880 1.00 103.31 ? 109 ARG B NH1 1 
ATOM 2298 N NH2 . ARG B 2 109 ? 206.811 286.138 83.910 1.00 101.67 ? 109 ARG B NH2 1 
ATOM 2299 N N   . LEU B 2 110 ? 204.533 279.307 81.044 1.00 90.76  ? 110 LEU B N   1 
ATOM 2300 C CA  . LEU B 2 110 ? 204.423 278.205 80.102 1.00 90.30  ? 110 LEU B CA  1 
ATOM 2301 C C   . LEU B 2 110 ? 204.305 276.842 80.796 1.00 92.00  ? 110 LEU B C   1 
ATOM 2302 O O   . LEU B 2 110 ? 204.167 275.820 80.119 1.00 88.09  ? 110 LEU B O   1 
ATOM 2303 C CB  . LEU B 2 110 ? 205.678 278.274 79.233 1.00 89.87  ? 110 LEU B CB  1 
ATOM 2304 C CG  . LEU B 2 110 ? 205.612 279.000 77.887 1.00 90.15  ? 110 LEU B CG  1 
ATOM 2305 C CD1 . LEU B 2 110 ? 204.856 278.161 76.862 1.00 94.11  ? 110 LEU B CD1 1 
ATOM 2306 C CD2 . LEU B 2 110 ? 205.024 280.380 78.001 1.00 91.14  ? 110 LEU B CD2 1 
ATOM 2307 N N   . GLN B 2 111 ? 204.377 276.799 82.135 1.00 91.67  ? 111 GLN B N   1 
ATOM 2308 C CA  . GLN B 2 111 ? 204.567 275.525 82.821 1.00 92.31  ? 111 GLN B CA  1 
ATOM 2309 C C   . GLN B 2 111 ? 203.253 274.750 82.908 1.00 90.30  ? 111 GLN B C   1 
ATOM 2310 O O   . GLN B 2 111 ? 203.224 273.636 83.420 1.00 92.70  ? 111 GLN B O   1 
ATOM 2311 C CB  . GLN B 2 111 ? 205.230 275.669 84.199 1.00 94.82  ? 111 GLN B CB  1 
ATOM 2312 C CG  . GLN B 2 111 ? 204.349 276.320 85.261 1.00 96.40  ? 111 GLN B CG  1 
ATOM 2313 C CD  . GLN B 2 111 ? 205.103 276.803 86.485 1.00 98.44  ? 111 GLN B CD  1 
ATOM 2314 O OE1 . GLN B 2 111 ? 206.304 276.551 86.679 1.00 95.18  ? 111 GLN B OE1 1 
ATOM 2315 N NE2 . GLN B 2 111 ? 204.382 277.525 87.332 1.00 99.06  ? 111 GLN B NE2 1 
ATOM 2316 N N   . SER B 2 112 ? 202.158 275.344 82.440 1.00 92.75  ? 112 SER B N   1 
ATOM 2317 C CA  . SER B 2 112 ? 200.953 274.582 82.149 1.00 94.36  ? 112 SER B CA  1 
ATOM 2318 C C   . SER B 2 112 ? 201.228 273.600 81.003 1.00 91.73  ? 112 SER B C   1 
ATOM 2319 O O   . SER B 2 112 ? 200.988 272.403 81.152 1.00 90.54  ? 112 SER B O   1 
ATOM 2320 C CB  . SER B 2 112 ? 199.787 275.515 81.844 1.00 94.86  ? 112 SER B CB  1 
ATOM 2321 O OG  . SER B 2 112 ? 200.120 276.457 80.825 1.00 94.42  ? 112 SER B OG  1 
ATOM 2322 N N   . GLU B 2 113 ? 201.777 274.123 79.893 1.00 90.06  ? 113 GLU B N   1 
ATOM 2323 C CA  . GLU B 2 113 ? 202.023 273.376 78.672 1.00 89.57  ? 113 GLU B CA  1 
ATOM 2324 C C   . GLU B 2 113 ? 203.290 272.523 78.767 1.00 88.27  ? 113 GLU B C   1 
ATOM 2325 O O   . GLU B 2 113 ? 203.297 271.371 78.334 1.00 85.71  ? 113 GLU B O   1 
ATOM 2326 C CB  . GLU B 2 113 ? 202.203 274.357 77.511 1.00 91.72  ? 113 GLU B CB  1 
ATOM 2327 C CG  . GLU B 2 113 ? 200.929 275.080 77.074 1.00 94.67  ? 113 GLU B CG  1 
ATOM 2328 C CD  . GLU B 2 113 ? 199.984 274.279 76.169 1.00 97.68  ? 113 GLU B CD  1 
ATOM 2329 O OE1 . GLU B 2 113 ? 200.079 273.017 76.061 1.00 95.93  ? 113 GLU B OE1 1 
ATOM 2330 O OE2 . GLU B 2 113 ? 199.119 274.956 75.551 1.00 96.47  ? 113 GLU B OE2 1 
ATOM 2331 N N   . VAL B 2 114 ? 204.371 273.111 79.301 1.00 88.18  ? 114 VAL B N   1 
ATOM 2332 C CA  . VAL B 2 114 ? 205.694 272.514 79.254 1.00 82.69  ? 114 VAL B CA  1 
ATOM 2333 C C   . VAL B 2 114 ? 206.220 272.354 80.678 1.00 81.20  ? 114 VAL B C   1 
ATOM 2334 O O   . VAL B 2 114 ? 206.920 273.221 81.195 1.00 82.75  ? 114 VAL B O   1 
ATOM 2335 C CB  . VAL B 2 114 ? 206.632 273.403 78.418 1.00 83.93  ? 114 VAL B CB  1 
ATOM 2336 C CG1 . VAL B 2 114 ? 207.920 272.667 78.083 1.00 84.47  ? 114 VAL B CG1 1 
ATOM 2337 C CG2 . VAL B 2 114 ? 205.974 273.966 77.161 1.00 85.89  ? 114 VAL B CG2 1 
ATOM 2338 N N   . ALA B 2 115 ? 205.920 271.219 81.306 1.00 82.90  ? 115 ALA B N   1 
ATOM 2339 C CA  . ALA B 2 115 ? 206.319 270.967 82.689 1.00 81.24  ? 115 ALA B CA  1 
ATOM 2340 C C   . ALA B 2 115 ? 207.830 271.044 82.906 1.00 78.41  ? 115 ALA B C   1 
ATOM 2341 O O   . ALA B 2 115 ? 208.265 271.426 83.986 1.00 80.21  ? 115 ALA B O   1 
ATOM 2342 C CB  . ALA B 2 115 ? 205.830 269.607 83.125 1.00 81.71  ? 115 ALA B CB  1 
ATOM 2343 N N   . GLU B 2 116 ? 208.627 270.632 81.914 1.00 79.58  ? 116 GLU B N   1 
ATOM 2344 C CA  . GLU B 2 116 ? 210.064 270.498 82.091 1.00 76.25  ? 116 GLU B CA  1 
ATOM 2345 C C   . GLU B 2 116 ? 210.711 271.869 82.127 1.00 75.75  ? 116 GLU B C   1 
ATOM 2346 O O   . GLU B 2 116 ? 211.822 271.998 82.624 1.00 76.38  ? 116 GLU B O   1 
ATOM 2347 C CB  . GLU B 2 116 ? 210.710 269.690 80.968 1.00 74.92  ? 116 GLU B CB  1 
ATOM 2348 C CG  . GLU B 2 116 ? 210.314 268.214 80.981 1.00 76.91  ? 116 GLU B CG  1 
ATOM 2349 C CD  . GLU B 2 116 ? 208.945 267.840 80.408 1.00 81.18  ? 116 GLU B CD  1 
ATOM 2350 O OE1 . GLU B 2 116 ? 208.212 268.707 79.827 1.00 76.53  ? 116 GLU B OE1 1 
ATOM 2351 O OE2 . GLU B 2 116 ? 208.617 266.628 80.569 1.00 77.83  ? 116 GLU B OE2 1 
ATOM 2352 N N   . LEU B 2 117 ? 210.016 272.880 81.600 1.00 77.45  ? 117 LEU B N   1 
ATOM 2353 C CA  . LEU B 2 117 ? 210.598 274.204 81.491 1.00 77.42  ? 117 LEU B CA  1 
ATOM 2354 C C   . LEU B 2 117 ? 210.747 274.799 82.888 1.00 77.28  ? 117 LEU B C   1 
ATOM 2355 O O   . LEU B 2 117 ? 211.638 275.598 83.141 1.00 79.83  ? 117 LEU B O   1 
ATOM 2356 C CB  . LEU B 2 117 ? 209.749 275.053 80.550 1.00 78.40  ? 117 LEU B CB  1 
ATOM 2357 C CG  . LEU B 2 117 ? 210.236 276.486 80.310 1.00 81.36  ? 117 LEU B CG  1 
ATOM 2358 C CD1 . LEU B 2 117 ? 211.638 276.566 79.705 1.00 82.48  ? 117 LEU B CD1 1 
ATOM 2359 C CD2 . LEU B 2 117 ? 209.241 277.214 79.410 1.00 85.43  ? 117 LEU B CD2 1 
ATOM 2360 N N   . LYS B 2 118 ? 209.920 274.350 83.819 1.00 77.37  ? 118 LYS B N   1 
ATOM 2361 C CA  . LYS B 2 118 ? 210.050 274.737 85.210 1.00 80.84  ? 118 LYS B CA  1 
ATOM 2362 C C   . LYS B 2 118 ? 211.327 274.172 85.831 1.00 79.88  ? 118 LYS B C   1 
ATOM 2363 O O   . LYS B 2 118 ? 212.043 274.877 86.538 1.00 83.44  ? 118 LYS B O   1 
ATOM 2364 C CB  . LYS B 2 118 ? 208.832 274.211 85.966 1.00 85.63  ? 118 LYS B CB  1 
ATOM 2365 C CG  . LYS B 2 118 ? 208.845 274.474 87.452 1.00 88.34  ? 118 LYS B CG  1 
ATOM 2366 C CD  . LYS B 2 118 ? 207.680 273.824 88.186 1.00 92.07  ? 118 LYS B CD  1 
ATOM 2367 C CE  . LYS B 2 118 ? 207.847 273.962 89.671 1.00 96.30  ? 118 LYS B CE  1 
ATOM 2368 N NZ  . LYS B 2 118 ? 207.986 275.362 90.104 1.00 99.55  ? 118 LYS B NZ  1 
ATOM 2369 N N   . ILE B 2 119 ? 211.606 272.895 85.572 1.00 78.73  ? 119 ILE B N   1 
ATOM 2370 C CA  . ILE B 2 119 ? 212.849 272.281 86.022 1.00 78.35  ? 119 ILE B CA  1 
ATOM 2371 C C   . ILE B 2 119 ? 214.055 273.035 85.460 1.00 77.77  ? 119 ILE B C   1 
ATOM 2372 O O   . ILE B 2 119 ? 214.965 273.371 86.201 1.00 82.38  ? 119 ILE B O   1 
ATOM 2373 C CB  . ILE B 2 119 ? 212.906 270.793 85.644 1.00 75.75  ? 119 ILE B CB  1 
ATOM 2374 C CG1 . ILE B 2 119 ? 211.824 270.004 86.344 1.00 72.34  ? 119 ILE B CG1 1 
ATOM 2375 C CG2 . ILE B 2 119 ? 214.285 270.211 85.939 1.00 77.58  ? 119 ILE B CG2 1 
ATOM 2376 C CD1 . ILE B 2 119 ? 211.553 268.669 85.696 1.00 77.56  ? 119 ILE B CD1 1 
ATOM 2377 N N   . VAL B 2 120 ? 214.044 273.344 84.170 1.00 77.01  ? 120 VAL B N   1 
ATOM 2378 C CA  . VAL B 2 120 ? 215.170 274.013 83.550 1.00 77.31  ? 120 VAL B CA  1 
ATOM 2379 C C   . VAL B 2 120 ? 215.513 275.303 84.303 1.00 81.41  ? 120 VAL B C   1 
ATOM 2380 O O   . VAL B 2 120 ? 216.703 275.586 84.464 1.00 84.93  ? 120 VAL B O   1 
ATOM 2381 C CB  . VAL B 2 120 ? 214.960 274.260 82.041 1.00 76.44  ? 120 VAL B CB  1 
ATOM 2382 C CG1 . VAL B 2 120 ? 216.064 275.120 81.435 1.00 78.96  ? 120 VAL B CG1 1 
ATOM 2383 C CG2 . VAL B 2 120 ? 214.848 272.951 81.271 1.00 72.79  ? 120 VAL B CG2 1 
ATOM 2384 N N   . ALA B 2 121 ? 214.523 276.085 84.762 1.00 81.72  ? 121 ALA B N   1 
ATOM 2385 C CA  . ALA B 2 121 ? 214.797 277.384 85.388 1.00 86.65  ? 121 ALA B CA  1 
ATOM 2386 C C   . ALA B 2 121 ? 214.978 277.287 86.903 1.00 87.50  ? 121 ALA B C   1 
ATOM 2387 O O   . ALA B 2 121 ? 215.482 278.227 87.509 1.00 92.24  ? 121 ALA B O   1 
ATOM 2388 C CB  . ALA B 2 121 ? 213.699 278.373 85.096 1.00 88.05  ? 121 ALA B CB  1 
ATOM 2389 N N   . ASP B 2 122 ? 214.498 276.211 87.522 1.00 86.09  ? 122 ASP B N   1 
ATOM 2390 C CA  . ASP B 2 122 ? 214.817 275.955 88.913 1.00 87.81  ? 122 ASP B CA  1 
ATOM 2391 C C   . ASP B 2 122 ? 216.292 275.612 88.956 1.00 88.64  ? 122 ASP B C   1 
ATOM 2392 O O   . ASP B 2 122 ? 216.970 275.855 89.951 1.00 93.03  ? 122 ASP B O   1 
ATOM 2393 C CB  . ASP B 2 122 ? 213.990 274.833 89.519 1.00 89.03  ? 122 ASP B CB  1 
ATOM 2394 C CG  . ASP B 2 122 ? 212.636 275.244 90.098 1.00 96.75  ? 122 ASP B CG  1 
ATOM 2395 O OD1 . ASP B 2 122 ? 212.108 276.343 89.720 1.00 94.81  ? 122 ASP B OD1 1 
ATOM 2396 O OD2 . ASP B 2 122 ? 212.107 274.467 90.940 1.00 100.19 ? 122 ASP B OD2 1 
ATOM 2397 N N   . GLN B 2 123 ? 216.764 275.049 87.849 1.00 87.32  ? 123 GLN B N   1 
ATOM 2398 C CA  . GLN B 2 123 ? 218.152 274.664 87.744 1.00 85.32  ? 123 GLN B CA  1 
ATOM 2399 C C   . GLN B 2 123 ? 218.996 275.885 87.439 1.00 88.59  ? 123 GLN B C   1 
ATOM 2400 O O   . GLN B 2 123 ? 220.159 275.913 87.809 1.00 95.87  ? 123 GLN B O   1 
ATOM 2401 C CB  . GLN B 2 123 ? 218.376 273.642 86.635 1.00 85.09  ? 123 GLN B CB  1 
ATOM 2402 C CG  . GLN B 2 123 ? 217.976 272.225 87.008 1.00 83.57  ? 123 GLN B CG  1 
ATOM 2403 C CD  . GLN B 2 123 ? 218.805 271.673 88.140 1.00 85.73  ? 123 GLN B CD  1 
ATOM 2404 O OE1 . GLN B 2 123 ? 219.873 272.203 88.455 1.00 91.82  ? 123 GLN B OE1 1 
ATOM 2405 N NE2 . GLN B 2 123 ? 218.338 270.596 88.755 1.00 87.12  ? 123 GLN B NE2 1 
ATOM 2406 N N   . LEU B 2 124 ? 218.443 276.855 86.717 1.00 88.35  ? 124 LEU B N   1 
ATOM 2407 C CA  . LEU B 2 124 ? 219.222 278.011 86.321 1.00 90.26  ? 124 LEU B CA  1 
ATOM 2408 C C   . LEU B 2 124 ? 219.265 279.012 87.470 1.00 95.26  ? 124 LEU B C   1 
ATOM 2409 O O   . LEU B 2 124 ? 220.258 279.717 87.634 1.00 99.70  ? 124 LEU B O   1 
ATOM 2410 C CB  . LEU B 2 124 ? 218.659 278.625 85.042 1.00 91.23  ? 124 LEU B CB  1 
ATOM 2411 C CG  . LEU B 2 124 ? 218.947 277.869 83.738 1.00 88.92  ? 124 LEU B CG  1 
ATOM 2412 C CD1 . LEU B 2 124 ? 218.109 278.456 82.618 1.00 89.72  ? 124 LEU B CD1 1 
ATOM 2413 C CD2 . LEU B 2 124 ? 220.411 277.905 83.337 1.00 87.12  ? 124 LEU B CD2 1 
ATOM 2414 N N   . CYS B 2 125 ? 218.201 279.060 88.274 1.00 95.79  ? 125 CYS B N   1 
ATOM 2415 C CA  . CYS B 2 125 ? 218.188 279.883 89.472 1.00 98.87  ? 125 CYS B CA  1 
ATOM 2416 C C   . CYS B 2 125 ? 219.116 279.305 90.538 1.00 101.84 ? 125 CYS B C   1 
ATOM 2417 O O   . CYS B 2 125 ? 219.572 280.033 91.410 1.00 105.79 ? 125 CYS B O   1 
ATOM 2418 C CB  . CYS B 2 125 ? 216.779 279.997 90.042 1.00 101.03 ? 125 CYS B CB  1 
ATOM 2419 S SG  . CYS B 2 125 ? 215.650 280.918 88.967 1.00 106.88 ? 125 CYS B SG  1 
ATOM 2420 N N   . ALA B 2 126 ? 219.358 277.991 90.501 1.00 98.16  ? 126 ALA B N   1 
ATOM 2421 C CA  . ALA B 2 126 ? 220.308 277.370 91.409 1.00 98.47  ? 126 ALA B CA  1 
ATOM 2422 C C   . ALA B 2 126 ? 221.725 277.749 90.990 1.00 100.64 ? 126 ALA B C   1 
ATOM 2423 O O   . ALA B 2 126 ? 222.532 278.156 91.819 1.00 103.60 ? 126 ALA B O   1 
ATOM 2424 C CB  . ALA B 2 126 ? 220.121 275.865 91.442 1.00 98.77  ? 126 ALA B CB  1 
ATOM 2425 N N   . LYS B 2 127 ? 222.012 277.610 89.699 1.00 99.28  ? 127 LYS B N   1 
ATOM 2426 C CA  . LYS B 2 127 ? 223.333 277.878 89.171 1.00 99.82  ? 127 LYS B CA  1 
ATOM 2427 C C   . LYS B 2 127 ? 223.701 279.344 89.352 1.00 102.06 ? 127 LYS B C   1 
ATOM 2428 O O   . LYS B 2 127 ? 224.852 279.644 89.647 1.00 103.75 ? 127 LYS B O   1 
ATOM 2429 C CB  . LYS B 2 127 ? 223.374 277.511 87.687 1.00 102.09 ? 127 LYS B CB  1 
ATOM 2430 C CG  . LYS B 2 127 ? 224.615 277.920 86.909 1.00 103.29 ? 127 LYS B CG  1 
ATOM 2431 C CD  . LYS B 2 127 ? 225.874 277.147 87.255 1.00 100.69 ? 127 LYS B CD  1 
ATOM 2432 C CE  . LYS B 2 127 ? 227.069 277.812 86.649 1.00 104.72 ? 127 LYS B CE  1 
ATOM 2433 N NZ  . LYS B 2 127 ? 228.292 277.039 86.875 1.00 106.04 ? 127 LYS B NZ  1 
ATOM 2434 N N   . TYR B 2 128 ? 222.739 280.250 89.167 1.00 103.29 ? 128 TYR B N   1 
ATOM 2435 C CA  . TYR B 2 128 ? 223.056 281.666 89.098 1.00 104.07 ? 128 TYR B CA  1 
ATOM 2436 C C   . TYR B 2 128 ? 222.339 282.459 90.189 1.00 107.27 ? 128 TYR B C   1 
ATOM 2437 O O   . TYR B 2 128 ? 222.157 283.661 90.032 1.00 111.56 ? 128 TYR B O   1 
ATOM 2438 C CB  . TYR B 2 128 ? 222.723 282.133 87.679 1.00 104.32 ? 128 TYR B CB  1 
ATOM 2439 C CG  . TYR B 2 128 ? 223.674 281.628 86.603 1.00 103.88 ? 128 TYR B CG  1 
ATOM 2440 C CD1 . TYR B 2 128 ? 225.043 281.817 86.717 1.00 105.16 ? 128 TYR B CD1 1 
ATOM 2441 C CD2 . TYR B 2 128 ? 223.212 280.963 85.473 1.00 104.62 ? 128 TYR B CD2 1 
ATOM 2442 C CE1 . TYR B 2 128 ? 225.920 281.379 85.741 1.00 107.38 ? 128 TYR B CE1 1 
ATOM 2443 C CE2 . TYR B 2 128 ? 224.081 280.507 84.493 1.00 104.71 ? 128 TYR B CE2 1 
ATOM 2444 C CZ  . TYR B 2 128 ? 225.439 280.721 84.626 1.00 106.50 ? 128 TYR B CZ  1 
ATOM 2445 O OH  . TYR B 2 128 ? 226.306 280.292 83.663 1.00 107.76 ? 128 TYR B OH  1 
ATOM 2446 N N   . SER B 2 129 ? 221.973 281.793 91.297 1.00 108.15 ? 129 SER B N   1 
ATOM 2447 C CA  . SER B 2 129 ? 221.446 282.422 92.510 1.00 111.25 ? 129 SER B CA  1 
ATOM 2448 C C   . SER B 2 129 ? 219.949 282.733 92.383 1.00 114.06 ? 129 SER B C   1 
ATOM 2449 O O   . SER B 2 129 ? 219.482 283.150 91.323 1.00 114.47 ? 129 SER B O   1 
ATOM 2450 C CB  . SER B 2 129 ? 222.224 283.666 92.910 1.00 112.10 ? 129 SER B CB  1 
ATOM 2451 O OG  . SER B 2 129 ? 221.723 284.841 92.286 1.00 114.40 ? 129 SER B OG  1 
ATOM 2452 N N   . LYS B 2 130 ? 219.213 282.545 93.494 1.00 117.37 ? 130 LYS B N   1 
ATOM 2453 C CA  . LYS B 2 130 ? 217.773 282.777 93.571 1.00 119.16 ? 130 LYS B CA  1 
ATOM 2454 C C   . LYS B 2 130 ? 217.444 284.265 93.411 1.00 121.78 ? 130 LYS B C   1 
ATOM 2455 O O   . LYS B 2 130 ? 216.357 284.613 92.944 1.00 122.08 ? 130 LYS B O   1 
ATOM 2456 C CB  . LYS B 2 130 ? 217.185 282.321 94.915 1.00 122.56 ? 130 LYS B CB  1 
ATOM 2457 C CG  . LYS B 2 130 ? 217.417 280.867 95.325 1.00 124.86 ? 130 LYS B CG  1 
ATOM 2458 C CD  . LYS B 2 130 ? 216.715 279.793 94.495 1.00 125.98 ? 130 LYS B CD  1 
ATOM 2459 C CE  . LYS B 2 130 ? 216.935 278.409 95.064 1.00 130.37 ? 130 LYS B CE  1 
ATOM 2460 N NZ  . LYS B 2 130 ? 216.256 277.336 94.326 1.00 131.90 ? 130 LYS B NZ  1 
ATOM 2461 N N   . GLU B 2 131 ? 218.385 285.130 93.815 1.00 121.27 ? 131 GLU B N   1 
ATOM 2462 C CA  . GLU B 2 131 ? 218.216 286.572 93.743 1.00 123.55 ? 131 GLU B CA  1 
ATOM 2463 C C   . GLU B 2 131 ? 218.150 287.024 92.284 1.00 121.84 ? 131 GLU B C   1 
ATOM 2464 O O   . GLU B 2 131 ? 217.256 287.789 91.915 1.00 122.67 ? 131 GLU B O   1 
ATOM 2465 C CB  . GLU B 2 131 ? 219.349 287.246 94.518 1.00 124.57 ? 131 GLU B CB  1 
ATOM 2466 C CG  . GLU B 2 131 ? 219.343 286.908 96.009 1.00 126.68 ? 131 GLU B CG  1 
ATOM 2467 C CD  . GLU B 2 131 ? 217.998 287.093 96.707 1.00 128.35 ? 131 GLU B CD  1 
ATOM 2468 O OE1 . GLU B 2 131 ? 217.455 288.224 96.641 1.00 127.46 ? 131 GLU B OE1 1 
ATOM 2469 O OE2 . GLU B 2 131 ? 217.491 286.112 97.312 1.00 127.15 ? 131 GLU B OE2 1 
ATOM 2470 N N   . TYR B 2 132 ? 219.093 286.543 91.465 1.00 119.51 ? 132 TYR B N   1 
ATOM 2471 C CA  . TYR B 2 132 ? 219.074 286.809 90.037 1.00 118.42 ? 132 TYR B CA  1 
ATOM 2472 C C   . TYR B 2 132 ? 217.812 286.218 89.407 1.00 120.18 ? 132 TYR B C   1 
ATOM 2473 O O   . TYR B 2 132 ? 217.225 286.838 88.518 1.00 120.50 ? 132 TYR B O   1 
ATOM 2474 C CB  . TYR B 2 132 ? 220.347 286.258 89.397 1.00 116.72 ? 132 TYR B CB  1 
ATOM 2475 C CG  . TYR B 2 132 ? 220.294 286.217 87.878 1.00 117.54 ? 132 TYR B CG  1 
ATOM 2476 C CD1 . TYR B 2 132 ? 220.621 287.339 87.123 1.00 117.96 ? 132 TYR B CD1 1 
ATOM 2477 C CD2 . TYR B 2 132 ? 219.918 285.060 87.198 1.00 115.61 ? 132 TYR B CD2 1 
ATOM 2478 C CE1 . TYR B 2 132 ? 220.588 287.309 85.737 1.00 117.59 ? 132 TYR B CE1 1 
ATOM 2479 C CE2 . TYR B 2 132 ? 219.887 285.016 85.813 1.00 110.85 ? 132 TYR B CE2 1 
ATOM 2480 C CZ  . TYR B 2 132 ? 220.222 286.145 85.083 1.00 113.65 ? 132 TYR B CZ  1 
ATOM 2481 O OH  . TYR B 2 132 ? 220.198 286.149 83.720 1.00 107.33 ? 132 TYR B OH  1 
ATOM 2482 N N   . GLY B 2 133 ? 217.394 285.031 89.880 1.00 119.86 ? 133 GLY B N   1 
ATOM 2483 C CA  . GLY B 2 133 ? 216.178 284.370 89.420 1.00 119.64 ? 133 GLY B CA  1 
ATOM 2484 C C   . GLY B 2 133 ? 214.906 285.196 89.648 1.00 121.96 ? 133 GLY B C   1 
ATOM 2485 O O   . GLY B 2 133 ? 213.959 285.097 88.866 1.00 120.01 ? 133 GLY B O   1 
ATOM 2486 N N   . LYS B 2 134 ? 214.876 285.989 90.728 1.00 122.12 ? 134 LYS B N   1 
ATOM 2487 C CA  . LYS B 2 134 ? 213.763 286.889 90.998 1.00 123.20 ? 134 LYS B CA  1 
ATOM 2488 C C   . LYS B 2 134 ? 213.829 288.114 90.083 1.00 122.18 ? 134 LYS B C   1 
ATOM 2489 O O   . LYS B 2 134 ? 212.796 288.546 89.572 1.00 122.22 ? 134 LYS B O   1 
ATOM 2490 C CB  . LYS B 2 134 ? 213.712 287.246 92.490 1.00 123.92 ? 134 LYS B CB  1 
ATOM 2491 C CG  . LYS B 2 134 ? 213.126 286.128 93.357 1.00 125.65 ? 134 LYS B CG  1 
ATOM 2492 C CD  . LYS B 2 134 ? 213.225 286.316 94.870 1.00 127.72 ? 134 LYS B CD  1 
ATOM 2493 C CE  . LYS B 2 134 ? 214.629 286.166 95.412 1.00 127.05 ? 134 LYS B CE  1 
ATOM 2494 N NZ  . LYS B 2 134 ? 214.676 286.183 96.878 1.00 128.35 ? 134 LYS B NZ  1 
ATOM 2495 N N   . LEU B 2 135 ? 215.036 288.659 89.867 1.00 122.40 ? 135 LEU B N   1 
ATOM 2496 C CA  . LEU B 2 135 ? 215.230 289.814 88.995 1.00 123.84 ? 135 LEU B CA  1 
ATOM 2497 C C   . LEU B 2 135 ? 214.850 289.482 87.549 1.00 121.58 ? 135 LEU B C   1 
ATOM 2498 O O   . LEU B 2 135 ? 214.475 290.374 86.787 1.00 121.35 ? 135 LEU B O   1 
ATOM 2499 C CB  . LEU B 2 135 ? 216.675 290.313 89.079 1.00 123.63 ? 135 LEU B CB  1 
ATOM 2500 C CG  . LEU B 2 135 ? 217.100 290.957 90.407 1.00 125.80 ? 135 LEU B CG  1 
ATOM 2501 C CD1 . LEU B 2 135 ? 218.616 291.175 90.432 1.00 127.28 ? 135 LEU B CD1 1 
ATOM 2502 C CD2 . LEU B 2 135 ? 216.363 292.275 90.692 1.00 126.02 ? 135 LEU B CD2 1 
ATOM 2503 N N   . CYS B 2 136 ? 214.963 288.202 87.177 1.00 120.56 ? 136 CYS B N   1 
ATOM 2504 C CA  . CYS B 2 136 ? 214.577 287.745 85.851 1.00 119.82 ? 136 CYS B CA  1 
ATOM 2505 C C   . CYS B 2 136 ? 213.058 287.691 85.711 1.00 120.01 ? 136 CYS B C   1 
ATOM 2506 O O   . CYS B 2 136 ? 212.532 288.204 84.728 1.00 115.65 ? 136 CYS B O   1 
ATOM 2507 C CB  . CYS B 2 136 ? 215.236 286.408 85.543 1.00 114.38 ? 136 CYS B CB  1 
ATOM 2508 S SG  . CYS B 2 136 ? 217.029 286.577 85.363 1.00 116.18 ? 136 CYS B SG  1 
ATOM 2509 N N   . ARG B 2 137 ? 212.367 287.101 86.699 1.00 120.02 ? 137 ARG B N   1 
ATOM 2510 C CA  . ARG B 2 137 ? 210.921 286.904 86.642 1.00 120.63 ? 137 ARG B CA  1 
ATOM 2511 C C   . ARG B 2 137 ? 210.149 288.229 86.573 1.00 120.35 ? 137 ARG B C   1 
ATOM 2512 O O   . ARG B 2 137 ? 209.043 288.253 86.030 1.00 116.38 ? 137 ARG B O   1 
ATOM 2513 C CB  . ARG B 2 137 ? 210.440 286.039 87.815 1.00 120.37 ? 137 ARG B CB  1 
ATOM 2514 C CG  . ARG B 2 137 ? 210.406 284.558 87.464 1.00 119.56 ? 137 ARG B CG  1 
ATOM 2515 C CD  . ARG B 2 137 ? 210.193 283.636 88.660 1.00 122.25 ? 137 ARG B CD  1 
ATOM 2516 N NE  . ARG B 2 137 ? 211.411 283.494 89.470 1.00 122.46 ? 137 ARG B NE  1 
ATOM 2517 C CZ  . ARG B 2 137 ? 211.627 282.578 90.412 1.00 124.20 ? 137 ARG B CZ  1 
ATOM 2518 N NH1 . ARG B 2 137 ? 212.788 282.571 91.059 1.00 122.43 ? 137 ARG B NH1 1 
ATOM 2519 N NH2 . ARG B 2 137 ? 210.703 281.668 90.707 1.00 125.28 ? 137 ARG B NH2 1 
ATOM 2520 N N   . THR B 2 138 ? 210.719 289.319 87.117 1.00 121.39 ? 138 THR B N   1 
ATOM 2521 C CA  . THR B 2 138 ? 210.107 290.646 87.073 1.00 122.55 ? 138 THR B CA  1 
ATOM 2522 C C   . THR B 2 138 ? 210.636 291.463 85.886 1.00 121.55 ? 138 THR B C   1 
ATOM 2523 O O   . THR B 2 138 ? 210.119 292.547 85.610 1.00 121.97 ? 138 THR B O   1 
ATOM 2524 C CB  . THR B 2 138 ? 210.382 291.383 88.389 1.00 124.83 ? 138 THR B CB  1 
ATOM 2525 O OG1 . THR B 2 138 ? 211.802 291.419 88.528 1.00 123.72 ? 138 THR B OG1 1 
ATOM 2526 C CG2 . THR B 2 138 ? 209.771 290.709 89.609 1.00 124.77 ? 138 THR B CG2 1 
ATOM 2527 N N   . ASN B 2 139 ? 211.671 290.938 85.208 1.00 120.56 ? 139 ASN B N   1 
ATOM 2528 C CA  . ASN B 2 139 ? 212.506 291.654 84.246 1.00 120.63 ? 139 ASN B CA  1 
ATOM 2529 C C   . ASN B 2 139 ? 213.071 292.958 84.828 1.00 121.64 ? 139 ASN B C   1 
ATOM 2530 O O   . ASN B 2 139 ? 213.322 293.910 84.083 1.00 120.48 ? 139 ASN B O   1 
ATOM 2531 C CB  . ASN B 2 139 ? 211.802 291.860 82.903 1.00 120.42 ? 139 ASN B CB  1 
ATOM 2532 C CG  . ASN B 2 139 ? 212.761 292.272 81.802 1.00 117.55 ? 139 ASN B CG  1 
ATOM 2533 O OD1 . ASN B 2 139 ? 213.935 291.875 81.810 1.00 114.96 ? 139 ASN B OD1 1 
ATOM 2534 N ND2 . ASN B 2 139 ? 212.300 293.076 80.852 1.00 117.92 ? 139 ASN B ND2 1 
ATOM 2535 N N   . GLN B 2 140 ? 213.348 292.983 86.144 1.00 122.60 ? 140 GLN B N   1 
ATOM 2536 C CA  . GLN B 2 140 ? 214.146 294.051 86.736 1.00 123.51 ? 140 GLN B CA  1 
ATOM 2537 C C   . GLN B 2 140 ? 215.590 293.953 86.231 1.00 122.54 ? 140 GLN B C   1 
ATOM 2538 O O   . GLN B 2 140 ? 216.322 294.942 86.262 1.00 122.34 ? 140 GLN B O   1 
ATOM 2539 C CB  . GLN B 2 140 ? 214.055 294.014 88.266 1.00 125.03 ? 140 GLN B CB  1 
ATOM 2540 C CG  . GLN B 2 140 ? 212.729 294.530 88.823 1.00 126.43 ? 140 GLN B CG  1 
ATOM 2541 C CD  . GLN B 2 140 ? 212.495 294.163 90.278 1.00 128.30 ? 140 GLN B CD  1 
ATOM 2542 O OE1 . GLN B 2 140 ? 212.397 292.983 90.641 1.00 126.91 ? 140 GLN B OE1 1 
ATOM 2543 N NE2 . GLN B 2 140 ? 212.382 295.172 91.134 1.00 130.18 ? 140 GLN B NE2 1 
ATOM 2544 N N   . ILE B 2 141 ? 215.980 292.754 85.760 1.00 121.84 ? 141 ILE B N   1 
ATOM 2545 C CA  . ILE B 2 141 ? 217.297 292.494 85.186 1.00 121.85 ? 141 ILE B CA  1 
ATOM 2546 C C   . ILE B 2 141 ? 217.428 293.131 83.794 1.00 119.40 ? 141 ILE B C   1 
ATOM 2547 O O   . ILE B 2 141 ? 218.544 293.264 83.288 1.00 118.11 ? 141 ILE B O   1 
ATOM 2548 C CB  . ILE B 2 141 ? 217.572 290.969 85.161 1.00 121.39 ? 141 ILE B CB  1 
ATOM 2549 C CG1 . ILE B 2 141 ? 219.080 290.632 85.053 1.00 121.78 ? 141 ILE B CG1 1 
ATOM 2550 C CG2 . ILE B 2 141 ? 216.760 290.266 84.065 1.00 119.66 ? 141 ILE B CG2 1 
ATOM 2551 C CD1 . ILE B 2 141 ? 219.904 290.950 86.293 1.00 121.78 ? 141 ILE B CD1 1 
ATOM 2552 N N   . GLY B 2 142 ? 216.298 293.490 83.163 1.00 119.16 ? 142 GLY B N   1 
ATOM 2553 C CA  . GLY B 2 142 ? 216.287 294.283 81.939 1.00 117.92 ? 142 GLY B CA  1 
ATOM 2554 C C   . GLY B 2 142 ? 216.874 293.557 80.725 1.00 114.90 ? 142 GLY B C   1 
ATOM 2555 O O   . GLY B 2 142 ? 217.280 294.214 79.766 1.00 115.53 ? 142 GLY B O   1 
ATOM 2556 N N   . THR B 2 143 ? 216.893 292.214 80.756 1.00 114.49 ? 143 THR B N   1 
ATOM 2557 C CA  . THR B 2 143 ? 217.627 291.415 79.778 1.00 112.44 ? 143 THR B CA  1 
ATOM 2558 C C   . THR B 2 143 ? 216.701 290.422 79.059 1.00 108.75 ? 143 THR B C   1 
ATOM 2559 O O   . THR B 2 143 ? 217.090 289.869 78.030 1.00 106.34 ? 143 THR B O   1 
ATOM 2560 C CB  . THR B 2 143 ? 218.790 290.712 80.492 1.00 111.40 ? 143 THR B CB  1 
ATOM 2561 O OG1 . THR B 2 143 ? 219.578 291.704 81.144 1.00 114.44 ? 143 THR B OG1 1 
ATOM 2562 C CG2 . THR B 2 143 ? 219.732 289.977 79.551 1.00 108.24 ? 143 THR B CG2 1 
ATOM 2563 N N   . VAL B 2 144 ? 215.478 290.216 79.577 1.00 107.18 ? 144 VAL B N   1 
ATOM 2564 C CA  . VAL B 2 144 ? 214.508 289.300 78.990 1.00 104.29 ? 144 VAL B CA  1 
ATOM 2565 C C   . VAL B 2 144 ? 214.109 289.811 77.606 1.00 102.49 ? 144 VAL B C   1 
ATOM 2566 O O   . VAL B 2 144 ? 213.978 291.017 77.404 1.00 104.55 ? 144 VAL B O   1 
ATOM 2567 C CB  . VAL B 2 144 ? 213.272 289.127 79.897 1.00 104.93 ? 144 VAL B CB  1 
ATOM 2568 C CG1 . VAL B 2 144 ? 212.186 288.270 79.251 1.00 103.00 ? 144 VAL B CG1 1 
ATOM 2569 C CG2 . VAL B 2 144 ? 213.635 288.558 81.262 1.00 104.16 ? 144 VAL B CG2 1 
ATOM 2570 N N   . ASN B 2 145 ? 213.895 288.877 76.672 1.00 101.12 ? 145 ASN B N   1 
ATOM 2571 C CA  . ASN B 2 145 ? 213.692 289.192 75.266 1.00 101.35 ? 145 ASN B CA  1 
ATOM 2572 C C   . ASN B 2 145 ? 212.329 289.861 75.053 1.00 102.00 ? 145 ASN B C   1 
ATOM 2573 O O   . ASN B 2 145 ? 211.296 289.258 75.338 1.00 100.31 ? 145 ASN B O   1 
ATOM 2574 C CB  . ASN B 2 145 ? 213.846 287.926 74.430 1.00 100.17 ? 145 ASN B CB  1 
ATOM 2575 C CG  . ASN B 2 145 ? 213.582 288.176 72.971 1.00 99.29  ? 145 ASN B CG  1 
ATOM 2576 O OD1 . ASN B 2 145 ? 212.462 287.955 72.509 1.00 100.01 ? 145 ASN B OD1 1 
ATOM 2577 N ND2 . ASN B 2 145 ? 214.567 288.676 72.242 1.00 101.97 ? 145 ASN B ND2 1 
ATOM 2578 N N   . ASP B 2 146 ? 212.321 291.085 74.499 1.00 103.79 ? 146 ASP B N   1 
ATOM 2579 C CA  . ASP B 2 146 ? 211.102 291.881 74.397 1.00 104.40 ? 146 ASP B CA  1 
ATOM 2580 C C   . ASP B 2 146 ? 210.109 291.314 73.382 1.00 102.37 ? 146 ASP B C   1 
ATOM 2581 O O   . ASP B 2 146 ? 208.905 291.526 73.528 1.00 101.04 ? 146 ASP B O   1 
ATOM 2582 C CB  . ASP B 2 146 ? 211.396 293.330 74.047 1.00 106.44 ? 146 ASP B CB  1 
ATOM 2583 C CG  . ASP B 2 146 ? 212.041 294.141 75.164 1.00 111.66 ? 146 ASP B CG  1 
ATOM 2584 O OD1 . ASP B 2 146 ? 211.509 294.102 76.303 1.00 111.09 ? 146 ASP B OD1 1 
ATOM 2585 O OD2 . ASP B 2 146 ? 213.069 294.813 74.889 1.00 111.88 ? 146 ASP B OD2 1 
ATOM 2586 N N   . ARG B 2 147 ? 210.602 290.622 72.349 1.00 100.94 ? 147 ARG B N   1 
ATOM 2587 C CA  . ARG B 2 147 ? 209.725 289.994 71.376 1.00 100.06 ? 147 ARG B CA  1 
ATOM 2588 C C   . ARG B 2 147 ? 208.949 288.841 72.019 1.00 98.16  ? 147 ARG B C   1 
ATOM 2589 O O   . ARG B 2 147 ? 207.799 288.616 71.660 1.00 99.30  ? 147 ARG B O   1 
ATOM 2590 C CB  . ARG B 2 147 ? 210.533 289.547 70.153 1.00 101.43 ? 147 ARG B CB  1 
ATOM 2591 C CG  . ARG B 2 147 ? 209.737 288.793 69.095 1.00 101.66 ? 147 ARG B CG  1 
ATOM 2592 C CD  . ARG B 2 147 ? 210.551 288.501 67.838 1.00 106.07 ? 147 ARG B CD  1 
ATOM 2593 N NE  . ARG B 2 147 ? 209.797 287.671 66.887 1.00 107.19 ? 147 ARG B NE  1 
ATOM 2594 C CZ  . ARG B 2 147 ? 210.071 286.413 66.490 1.00 107.09 ? 147 ARG B CZ  1 
ATOM 2595 N NH1 . ARG B 2 147 ? 209.129 285.729 65.841 1.00 108.40 ? 147 ARG B NH1 1 
ATOM 2596 N NH2 . ARG B 2 147 ? 211.234 285.820 66.777 1.00 103.28 ? 147 ARG B NH2 1 
ATOM 2597 N N   . LEU B 2 148 ? 209.563 288.112 72.955 1.00 97.78  ? 148 LEU B N   1 
ATOM 2598 C CA  . LEU B 2 148 ? 208.909 286.969 73.567 1.00 96.00  ? 148 LEU B CA  1 
ATOM 2599 C C   . LEU B 2 148 ? 207.838 287.457 74.535 1.00 97.34  ? 148 LEU B C   1 
ATOM 2600 O O   . LEU B 2 148 ? 206.813 286.795 74.708 1.00 96.22  ? 148 LEU B O   1 
ATOM 2601 C CB  . LEU B 2 148 ? 209.863 286.040 74.311 1.00 95.80  ? 148 LEU B CB  1 
ATOM 2602 C CG  . LEU B 2 148 ? 209.191 284.794 74.906 1.00 94.24  ? 148 LEU B CG  1 
ATOM 2603 C CD1 . LEU B 2 148 ? 209.319 283.611 73.965 1.00 88.99  ? 148 LEU B CD1 1 
ATOM 2604 C CD2 . LEU B 2 148 ? 209.695 284.465 76.291 1.00 92.80  ? 148 LEU B CD2 1 
ATOM 2605 N N   . MET B 2 149 ? 208.106 288.582 75.202 1.00 98.34  ? 149 MET B N   1 
ATOM 2606 C CA  . MET B 2 149 ? 207.200 289.113 76.207 1.00 98.41  ? 149 MET B CA  1 
ATOM 2607 C C   . MET B 2 149 ? 205.932 289.642 75.537 1.00 98.18  ? 149 MET B C   1 
ATOM 2608 O O   . MET B 2 149 ? 204.841 289.499 76.088 1.00 97.29  ? 149 MET B O   1 
ATOM 2609 C CB  . MET B 2 149 ? 207.877 290.223 77.017 1.00 99.92  ? 149 MET B CB  1 
ATOM 2610 C CG  . MET B 2 149 ? 208.952 289.711 77.956 1.00 100.78 ? 149 MET B CG  1 
ATOM 2611 S SD  . MET B 2 149 ? 209.867 291.016 78.797 1.00 107.37 ? 149 MET B SD  1 
ATOM 2612 C CE  . MET B 2 149 ? 208.654 291.655 79.957 1.00 105.36 ? 149 MET B CE  1 
ATOM 2613 N N   . HIS B 2 150 ? 206.081 290.253 74.357 1.00 98.12  ? 150 HIS B N   1 
ATOM 2614 C CA  . HIS B 2 150 ? 204.929 290.696 73.594 1.00 98.90  ? 150 HIS B CA  1 
ATOM 2615 C C   . HIS B 2 150 ? 204.091 289.487 73.183 1.00 98.07  ? 150 HIS B C   1 
ATOM 2616 O O   . HIS B 2 150 ? 202.863 289.513 73.259 1.00 99.18  ? 150 HIS B O   1 
ATOM 2617 C CB  . HIS B 2 150 ? 205.336 291.523 72.371 1.00 100.06 ? 150 HIS B CB  1 
ATOM 2618 C CG  . HIS B 2 150 ? 204.225 291.636 71.386 1.00 101.47 ? 150 HIS B CG  1 
ATOM 2619 N ND1 . HIS B 2 150 ? 204.196 290.943 70.192 1.00 103.41 ? 150 HIS B ND1 1 
ATOM 2620 C CD2 . HIS B 2 150 ? 203.075 292.336 71.439 1.00 104.17 ? 150 HIS B CD2 1 
ATOM 2621 C CE1 . HIS B 2 150 ? 203.068 291.228 69.544 1.00 105.21 ? 150 HIS B CE1 1 
ATOM 2622 N NE2 . HIS B 2 150 ? 202.369 292.072 70.285 1.00 104.70 ? 150 HIS B NE2 1 
ATOM 2623 N N   . LYS B 2 151 ? 204.763 288.423 72.754 1.00 97.05  ? 151 LYS B N   1 
ATOM 2624 C CA  . LYS B 2 151 ? 204.067 287.250 72.263 1.00 94.12  ? 151 LYS B CA  1 
ATOM 2625 C C   . LYS B 2 151 ? 203.475 286.429 73.400 1.00 93.28  ? 151 LYS B C   1 
ATOM 2626 O O   . LYS B 2 151 ? 202.791 285.450 73.137 1.00 93.15  ? 151 LYS B O   1 
ATOM 2627 C CB  . LYS B 2 151 ? 204.994 286.371 71.425 1.00 94.45  ? 151 LYS B CB  1 
ATOM 2628 C CG  . LYS B 2 151 ? 205.364 287.021 70.115 1.00 96.88  ? 151 LYS B CG  1 
ATOM 2629 C CD  . LYS B 2 151 ? 206.376 286.214 69.320 1.00 98.28  ? 151 LYS B CD  1 
ATOM 2630 C CE  . LYS B 2 151 ? 206.911 286.971 68.148 1.00 103.62 ? 151 LYS B CE  1 
ATOM 2631 N NZ  . LYS B 2 151 ? 205.891 287.510 67.235 1.00 105.14 ? 151 LYS B NZ  1 
ATOM 2632 N N   . LEU B 2 152 ? 203.710 286.813 74.653 1.00 94.55  ? 152 LEU B N   1 
ATOM 2633 C CA  . LEU B 2 152 ? 203.054 286.140 75.757 1.00 91.83  ? 152 LEU B CA  1 
ATOM 2634 C C   . LEU B 2 152 ? 202.343 287.151 76.643 1.00 93.53  ? 152 LEU B C   1 
ATOM 2635 O O   . LEU B 2 152 ? 202.149 286.884 77.825 1.00 95.72  ? 152 LEU B O   1 
ATOM 2636 C CB  . LEU B 2 152 ? 204.091 285.348 76.545 1.00 92.43  ? 152 LEU B CB  1 
ATOM 2637 C CG  . LEU B 2 152 ? 204.739 284.152 75.839 1.00 92.47  ? 152 LEU B CG  1 
ATOM 2638 C CD1 . LEU B 2 152 ? 205.796 283.559 76.768 1.00 93.48  ? 152 LEU B CD1 1 
ATOM 2639 C CD2 . LEU B 2 152 ? 203.757 283.066 75.409 1.00 89.66  ? 152 LEU B CD2 1 
ATOM 2640 N N   . SER B 2 153 ? 201.949 288.298 76.074 1.00 96.08  ? 153 SER B N   1 
ATOM 2641 C CA  . SER B 2 153 ? 201.167 289.289 76.802 1.00 97.13  ? 153 SER B CA  1 
ATOM 2642 C C   . SER B 2 153 ? 199.796 288.724 77.144 1.00 97.97  ? 153 SER B C   1 
ATOM 2643 O O   . SER B 2 153 ? 199.295 287.860 76.431 1.00 98.81  ? 153 SER B O   1 
ATOM 2644 C CB  . SER B 2 153 ? 201.008 290.554 76.013 1.00 99.29  ? 153 SER B CB  1 
ATOM 2645 O OG  . SER B 2 153 ? 202.247 291.234 75.871 1.00 100.89 ? 153 SER B OG  1 
ATOM 2646 N N   . VAL B 2 154 ? 199.174 289.241 78.206 1.00 100.20 ? 154 VAL B N   1 
ATOM 2647 C CA  . VAL B 2 154 ? 197.816 288.836 78.544 1.00 100.51 ? 154 VAL B CA  1 
ATOM 2648 C C   . VAL B 2 154 ? 196.809 289.797 77.914 1.00 102.19 ? 154 VAL B C   1 
ATOM 2649 O O   . VAL B 2 154 ? 195.625 289.484 77.871 1.00 105.69 ? 154 VAL B O   1 
ATOM 2650 C CB  . VAL B 2 154 ? 197.547 288.702 80.052 1.00 100.36 ? 154 VAL B CB  1 
ATOM 2651 C CG1 . VAL B 2 154 ? 198.349 287.555 80.655 1.00 99.16  ? 154 VAL B CG1 1 
ATOM 2652 C CG2 . VAL B 2 154 ? 197.770 290.021 80.788 1.00 103.86 ? 154 VAL B CG2 1 
ATOM 2653 N N   . GLU B 2 155 ? 197.282 290.918 77.375 1.00 102.32 ? 155 GLU B N   1 
ATOM 2654 C CA  . GLU B 2 155 ? 196.422 291.946 76.822 1.00 103.51 ? 155 GLU B CA  1 
ATOM 2655 C C   . GLU B 2 155 ? 195.738 291.458 75.550 1.00 107.88 ? 155 GLU B C   1 
ATOM 2656 O O   . GLU B 2 155 ? 196.190 290.499 74.925 1.00 108.07 ? 155 GLU B O   1 
ATOM 2657 C CB  . GLU B 2 155 ? 197.248 293.182 76.472 1.00 106.94 ? 155 GLU B CB  1 
ATOM 2658 C CG  . GLU B 2 155 ? 197.732 293.982 77.681 1.00 108.69 ? 155 GLU B CG  1 
ATOM 2659 C CD  . GLU B 2 155 ? 198.514 293.233 78.765 1.00 109.31 ? 155 GLU B CD  1 
ATOM 2660 O OE1 . GLU B 2 155 ? 199.324 292.311 78.445 1.00 104.10 ? 155 GLU B OE1 1 
ATOM 2661 O OE2 . GLU B 2 155 ? 198.332 293.613 79.956 1.00 108.45 ? 155 GLU B OE2 1 
ATOM 2662 N N   . ALA B 2 156 ? 194.650 292.152 75.178 1.00 108.39 ? 156 ALA B N   1 
ATOM 2663 C CA  . ALA B 2 156 ? 193.868 291.833 73.997 1.00 108.48 ? 156 ALA B CA  1 
ATOM 2664 C C   . ALA B 2 156 ? 194.619 292.270 72.745 1.00 110.28 ? 156 ALA B C   1 
ATOM 2665 O O   . ALA B 2 156 ? 195.360 293.251 72.797 1.00 111.22 ? 156 ALA B O   1 
ATOM 2666 C CB  . ALA B 2 156 ? 192.524 292.519 74.086 1.00 111.17 ? 156 ALA B CB  1 
ATOM 2667 N N   . PRO B 2 157 ? 194.448 291.582 71.590 1.00 110.72 ? 157 PRO B N   1 
ATOM 2668 C CA  . PRO B 2 157 ? 194.989 292.071 70.321 1.00 112.00 ? 157 PRO B CA  1 
ATOM 2669 C C   . PRO B 2 157 ? 194.460 293.461 69.979 1.00 114.51 ? 157 PRO B C   1 
ATOM 2670 O O   . PRO B 2 157 ? 193.377 293.830 70.418 1.00 114.83 ? 157 PRO B O   1 
ATOM 2671 C CB  . PRO B 2 157 ? 194.539 291.037 69.282 1.00 112.16 ? 157 PRO B CB  1 
ATOM 2672 C CG  . PRO B 2 157 ? 194.216 289.801 70.078 1.00 109.76 ? 157 PRO B CG  1 
ATOM 2673 C CD  . PRO B 2 157 ? 193.759 290.291 71.441 1.00 110.01 ? 157 PRO B CD  1 
ATOM 2674 N N   . PRO B 2 158 ? 195.198 294.282 69.195 1.00 116.81 ? 158 PRO B N   1 
ATOM 2675 C CA  . PRO B 2 158 ? 194.624 295.494 68.612 1.00 118.59 ? 158 PRO B CA  1 
ATOM 2676 C C   . PRO B 2 158 ? 193.450 295.096 67.725 1.00 120.97 ? 158 PRO B C   1 
ATOM 2677 O O   . PRO B 2 158 ? 193.562 294.140 66.958 1.00 119.54 ? 158 PRO B O   1 
ATOM 2678 C CB  . PRO B 2 158 ? 195.770 296.123 67.801 1.00 120.19 ? 158 PRO B CB  1 
ATOM 2679 C CG  . PRO B 2 158 ? 197.028 295.502 68.371 1.00 121.25 ? 158 PRO B CG  1 
ATOM 2680 C CD  . PRO B 2 158 ? 196.619 294.112 68.844 1.00 118.69 ? 158 PRO B CD  1 
ATOM 2681 N N   . LYS B 2 159 ? 192.341 295.844 67.805 1.00 121.31 ? 159 LYS B N   1 
ATOM 2682 C CA  . LYS B 2 159 ? 191.132 295.460 67.088 1.00 124.19 ? 159 LYS B CA  1 
ATOM 2683 C C   . LYS B 2 159 ? 191.339 295.577 65.577 1.00 123.29 ? 159 LYS B C   1 
ATOM 2684 O O   . LYS B 2 159 ? 190.641 294.905 64.818 1.00 121.39 ? 159 LYS B O   1 
ATOM 2685 C CB  . LYS B 2 159 ? 189.857 296.167 67.570 1.00 128.49 ? 159 LYS B CB  1 
ATOM 2686 C CG  . LYS B 2 159 ? 189.913 297.634 67.989 1.00 131.31 ? 159 LYS B CG  1 
ATOM 2687 C CD  . LYS B 2 159 ? 188.677 298.021 68.803 1.00 133.36 ? 159 LYS B CD  1 
ATOM 2688 C CE  . LYS B 2 159 ? 188.740 299.378 69.452 1.00 136.57 ? 159 LYS B CE  1 
ATOM 2689 N NZ  . LYS B 2 159 ? 188.613 300.507 68.519 1.00 139.10 ? 159 LYS B NZ  1 
ATOM 2690 N N   . ILE B 2 160 ? 192.309 296.394 65.150 1.00 124.26 ? 160 ILE B N   1 
ATOM 2691 C CA  . ILE B 2 160 ? 192.693 296.473 63.746 1.00 124.08 ? 160 ILE B CA  1 
ATOM 2692 C C   . ILE B 2 160 ? 193.298 295.143 63.286 1.00 121.28 ? 160 ILE B C   1 
ATOM 2693 O O   . ILE B 2 160 ? 193.137 294.772 62.126 1.00 121.49 ? 160 ILE B O   1 
ATOM 2694 C CB  . ILE B 2 160 ? 193.623 297.684 63.485 1.00 124.98 ? 160 ILE B CB  1 
ATOM 2695 C CG1 . ILE B 2 160 ? 194.034 297.810 61.995 1.00 130.24 ? 160 ILE B CG1 1 
ATOM 2696 C CG2 . ILE B 2 160 ? 194.854 297.678 64.400 1.00 124.58 ? 160 ILE B CG2 1 
ATOM 2697 C CD1 . ILE B 2 160 ? 192.881 298.000 61.020 1.00 130.71 ? 160 ILE B CD1 1 
ATOM 2698 N N   . LEU B 2 161 ? 193.983 294.423 64.185 1.00 120.30 ? 161 LEU B N   1 
ATOM 2699 C CA  . LEU B 2 161 ? 194.592 293.150 63.828 1.00 118.61 ? 161 LEU B CA  1 
ATOM 2700 C C   . LEU B 2 161 ? 193.504 292.085 63.704 1.00 117.42 ? 161 LEU B C   1 
ATOM 2701 O O   . LEU B 2 161 ? 193.577 291.234 62.820 1.00 117.52 ? 161 LEU B O   1 
ATOM 2702 C CB  . LEU B 2 161 ? 195.681 292.746 64.826 1.00 118.28 ? 161 LEU B CB  1 
ATOM 2703 C CG  . LEU B 2 161 ? 196.368 291.392 64.593 1.00 117.12 ? 161 LEU B CG  1 
ATOM 2704 C CD1 . LEU B 2 161 ? 197.118 291.316 63.266 1.00 119.36 ? 161 LEU B CD1 1 
ATOM 2705 C CD2 . LEU B 2 161 ? 197.307 291.054 65.739 1.00 113.99 ? 161 LEU B CD2 1 
ATOM 2706 N N   . VAL B 2 162 ? 192.503 292.140 64.590 1.00 117.40 ? 162 VAL B N   1 
ATOM 2707 C CA  . VAL B 2 162 ? 191.359 291.241 64.531 1.00 116.34 ? 162 VAL B CA  1 
ATOM 2708 C C   . VAL B 2 162 ? 190.663 291.417 63.180 1.00 116.08 ? 162 VAL B C   1 
ATOM 2709 O O   . VAL B 2 162 ? 190.354 290.436 62.509 1.00 115.37 ? 162 VAL B O   1 
ATOM 2710 C CB  . VAL B 2 162 ? 190.400 291.469 65.721 1.00 114.68 ? 162 VAL B CB  1 
ATOM 2711 C CG1 . VAL B 2 162 ? 189.115 290.647 65.618 1.00 110.68 ? 162 VAL B CG1 1 
ATOM 2712 C CG2 . VAL B 2 162 ? 191.081 291.203 67.059 1.00 112.71 ? 162 VAL B CG2 1 
ATOM 2713 N N   . GLU B 2 163 ? 190.436 292.673 62.777 1.00 118.08 ? 163 GLU B N   1 
ATOM 2714 C CA  . GLU B 2 163 ? 189.795 292.961 61.503 1.00 119.65 ? 163 GLU B CA  1 
ATOM 2715 C C   . GLU B 2 163 ? 190.648 292.446 60.344 1.00 119.01 ? 163 GLU B C   1 
ATOM 2716 O O   . GLU B 2 163 ? 190.123 291.791 59.447 1.00 118.75 ? 163 GLU B O   1 
ATOM 2717 C CB  . GLU B 2 163 ? 189.464 294.448 61.355 1.00 121.28 ? 163 GLU B CB  1 
ATOM 2718 C CG  . GLU B 2 163 ? 188.289 294.893 62.224 1.00 122.66 ? 163 GLU B CG  1 
ATOM 2719 C CD  . GLU B 2 163 ? 186.955 294.225 61.929 1.00 122.73 ? 163 GLU B CD  1 
ATOM 2720 O OE1 . GLU B 2 163 ? 186.762 293.754 60.785 1.00 124.90 ? 163 GLU B OE1 1 
ATOM 2721 O OE2 . GLU B 2 163 ? 186.112 294.150 62.854 1.00 122.51 ? 163 GLU B OE2 1 
ATOM 2722 N N   . ARG B 2 164 ? 191.956 292.718 60.369 1.00 118.21 ? 164 ARG B N   1 
ATOM 2723 C CA  . ARG B 2 164 ? 192.844 292.281 59.302 1.00 118.78 ? 164 ARG B CA  1 
ATOM 2724 C C   . ARG B 2 164 ? 192.858 290.754 59.187 1.00 118.09 ? 164 ARG B C   1 
ATOM 2725 O O   . ARG B 2 164 ? 192.884 290.231 58.074 1.00 119.46 ? 164 ARG B O   1 
ATOM 2726 C CB  . ARG B 2 164 ? 194.232 292.894 59.511 1.00 121.04 ? 164 ARG B CB  1 
ATOM 2727 C CG  . ARG B 2 164 ? 194.307 294.325 58.999 1.00 123.44 ? 164 ARG B CG  1 
ATOM 2728 C CD  . ARG B 2 164 ? 195.625 295.006 59.300 1.00 126.76 ? 164 ARG B CD  1 
ATOM 2729 N NE  . ARG B 2 164 ? 195.636 296.360 58.734 1.00 129.01 ? 164 ARG B NE  1 
ATOM 2730 C CZ  . ARG B 2 164 ? 196.399 297.379 59.134 1.00 131.78 ? 164 ARG B CZ  1 
ATOM 2731 N NH1 . ARG B 2 164 ? 196.302 298.545 58.512 1.00 134.22 ? 164 ARG B NH1 1 
ATOM 2732 N NH2 . ARG B 2 164 ? 197.251 297.247 60.146 1.00 132.04 ? 164 ARG B NH2 1 
ATOM 2733 N N   . TYR B 2 165 ? 192.771 290.077 60.339 1.00 116.86 ? 165 TYR B N   1 
ATOM 2734 C CA  . TYR B 2 165 ? 192.707 288.593 60.394 1.00 114.57 ? 165 TYR B CA  1 
ATOM 2735 C C   . TYR B 2 165 ? 191.429 288.109 59.732 1.00 117.04 ? 165 TYR B C   1 
ATOM 2736 O O   . TYR B 2 165 ? 191.483 287.094 59.031 1.00 118.62 ? 165 TYR B O   1 
ATOM 2737 C CB  . TYR B 2 165 ? 192.689 288.129 61.850 1.00 112.36 ? 165 TYR B CB  1 
ATOM 2738 C CG  . TYR B 2 165 ? 193.902 287.345 62.323 1.00 111.61 ? 165 TYR B CG  1 
ATOM 2739 C CD1 . TYR B 2 165 ? 195.140 287.955 62.466 1.00 112.20 ? 165 TYR B CD1 1 
ATOM 2740 C CD2 . TYR B 2 165 ? 193.795 286.000 62.649 1.00 110.24 ? 165 TYR B CD2 1 
ATOM 2741 C CE1 . TYR B 2 165 ? 196.244 287.244 62.904 1.00 110.93 ? 165 TYR B CE1 1 
ATOM 2742 C CE2 . TYR B 2 165 ? 194.889 285.279 63.090 1.00 108.22 ? 165 TYR B CE2 1 
ATOM 2743 C CZ  . TYR B 2 165 ? 196.115 285.903 63.217 1.00 111.06 ? 165 TYR B CZ  1 
ATOM 2744 O OH  . TYR B 2 165 ? 197.187 285.189 63.658 1.00 110.03 ? 165 TYR B OH  1 
ATOM 2745 N N   . LEU B 2 166 ? 190.302 288.776 59.999 1.00 116.82 ? 166 LEU B N   1 
ATOM 2746 C CA  . LEU B 2 166 ? 189.022 288.379 59.429 1.00 115.95 ? 166 LEU B CA  1 
ATOM 2747 C C   . LEU B 2 166 ? 189.018 288.612 57.920 1.00 118.16 ? 166 LEU B C   1 
ATOM 2748 O O   . LEU B 2 166 ? 188.505 287.778 57.181 1.00 118.94 ? 166 LEU B O   1 
ATOM 2749 C CB  . LEU B 2 166 ? 187.878 289.118 60.125 1.00 116.62 ? 166 LEU B CB  1 
ATOM 2750 C CG  . LEU B 2 166 ? 187.512 288.628 61.533 1.00 112.17 ? 166 LEU B CG  1 
ATOM 2751 C CD1 . LEU B 2 166 ? 186.586 289.591 62.262 1.00 114.53 ? 166 LEU B CD1 1 
ATOM 2752 C CD2 . LEU B 2 166 ? 186.881 287.248 61.506 1.00 106.51 ? 166 LEU B CD2 1 
ATOM 2753 N N   . ILE B 2 167 ? 189.607 289.731 57.476 1.00 119.38 ? 167 ILE B N   1 
ATOM 2754 C CA  . ILE B 2 167 ? 189.642 290.093 56.065 1.00 120.23 ? 167 ILE B CA  1 
ATOM 2755 C C   . ILE B 2 167 ? 190.403 289.028 55.272 1.00 120.15 ? 167 ILE B C   1 
ATOM 2756 O O   . ILE B 2 167 ? 189.973 288.645 54.186 1.00 121.92 ? 167 ILE B O   1 
ATOM 2757 C CB  . ILE B 2 167 ? 190.247 291.501 55.886 1.00 121.00 ? 167 ILE B CB  1 
ATOM 2758 C CG1 . ILE B 2 167 ? 189.309 292.587 56.443 1.00 121.31 ? 167 ILE B CG1 1 
ATOM 2759 C CG2 . ILE B 2 167 ? 190.619 291.771 54.425 1.00 123.43 ? 167 ILE B CG2 1 
ATOM 2760 C CD1 . ILE B 2 167 ? 189.989 293.904 56.780 1.00 124.34 ? 167 ILE B CD1 1 
ATOM 2761 N N   . GLU B 2 168 ? 191.530 288.559 55.818 1.00 120.81 ? 168 GLU B N   1 
ATOM 2762 C CA  . GLU B 2 168 ? 192.376 287.600 55.125 1.00 122.87 ? 168 GLU B CA  1 
ATOM 2763 C C   . GLU B 2 168 ? 191.752 286.207 55.140 1.00 120.93 ? 168 GLU B C   1 
ATOM 2764 O O   . GLU B 2 168 ? 191.893 285.473 54.165 1.00 122.49 ? 168 GLU B O   1 
ATOM 2765 C CB  . GLU B 2 168 ? 193.782 287.558 55.726 1.00 123.61 ? 168 GLU B CB  1 
ATOM 2766 C CG  . GLU B 2 168 ? 194.624 288.799 55.435 1.00 124.60 ? 168 GLU B CG  1 
ATOM 2767 C CD  . GLU B 2 168 ? 194.894 289.038 53.961 1.00 129.38 ? 168 GLU B CD  1 
ATOM 2768 O OE1 . GLU B 2 168 ? 195.350 288.088 53.277 1.00 130.79 ? 168 GLU B OE1 1 
ATOM 2769 O OE2 . GLU B 2 168 ? 194.648 290.177 53.499 1.00 129.84 ? 168 GLU B OE2 1 
ATOM 2770 N N   . ILE B 2 169 ? 191.083 285.839 56.241 1.00 119.38 ? 169 ILE B N   1 
ATOM 2771 C CA  . ILE B 2 169 ? 190.427 284.541 56.327 1.00 118.91 ? 169 ILE B CA  1 
ATOM 2772 C C   . ILE B 2 169 ? 189.236 284.532 55.367 1.00 120.23 ? 169 ILE B C   1 
ATOM 2773 O O   . ILE B 2 169 ? 189.009 283.536 54.686 1.00 120.62 ? 169 ILE B O   1 
ATOM 2774 C CB  . ILE B 2 169 ? 190.032 284.199 57.780 1.00 117.72 ? 169 ILE B CB  1 
ATOM 2775 C CG1 . ILE B 2 169 ? 191.270 283.960 58.654 1.00 116.79 ? 169 ILE B CG1 1 
ATOM 2776 C CG2 . ILE B 2 169 ? 189.075 283.005 57.834 1.00 115.26 ? 169 ILE B CG2 1 
ATOM 2777 C CD1 . ILE B 2 169 ? 191.012 283.990 60.150 1.00 115.79 ? 169 ILE B CD1 1 
ATOM 2778 N N   . ALA B 2 170 ? 188.506 285.651 55.282 1.00 120.18 ? 170 ALA B N   1 
ATOM 2779 C CA  . ALA B 2 170 ? 187.349 285.749 54.404 1.00 121.17 ? 170 ALA B CA  1 
ATOM 2780 C C   . ALA B 2 170 ? 187.735 285.536 52.938 1.00 122.74 ? 170 ALA B C   1 
ATOM 2781 O O   . ALA B 2 170 ? 186.978 284.917 52.196 1.00 122.74 ? 170 ALA B O   1 
ATOM 2782 C CB  . ALA B 2 170 ? 186.667 287.086 54.597 1.00 121.93 ? 170 ALA B CB  1 
ATOM 2783 N N   . LYS B 2 171 ? 188.895 286.059 52.514 1.00 122.48 ? 171 LYS B N   1 
ATOM 2784 C CA  . LYS B 2 171 ? 189.347 285.906 51.139 1.00 123.46 ? 171 LYS B CA  1 
ATOM 2785 C C   . LYS B 2 171 ? 189.590 284.437 50.803 1.00 123.35 ? 171 LYS B C   1 
ATOM 2786 O O   . LYS B 2 171 ? 189.196 283.983 49.730 1.00 124.51 ? 171 LYS B O   1 
ATOM 2787 C CB  . LYS B 2 171 ? 190.656 286.652 50.857 1.00 124.68 ? 171 LYS B CB  1 
ATOM 2788 C CG  . LYS B 2 171 ? 190.548 288.171 50.811 1.00 127.06 ? 171 LYS B CG  1 
ATOM 2789 C CD  . LYS B 2 171 ? 191.893 288.893 50.890 1.00 128.51 ? 171 LYS B CD  1 
ATOM 2790 C CE  . LYS B 2 171 ? 191.755 290.381 51.090 1.00 129.00 ? 171 LYS B CE  1 
ATOM 2791 N NZ  . LYS B 2 171 ? 193.015 291.066 51.406 1.00 129.15 ? 171 LYS B NZ  1 
ATOM 2792 N N   . ASN B 2 172 ? 190.248 283.708 51.713 1.00 122.40 ? 172 ASN B N   1 
ATOM 2793 C CA  . ASN B 2 172 ? 190.746 282.376 51.408 1.00 123.23 ? 172 ASN B CA  1 
ATOM 2794 C C   . ASN B 2 172 ? 189.619 281.348 51.394 1.00 122.50 ? 172 ASN B C   1 
ATOM 2795 O O   . ASN B 2 172 ? 189.758 280.312 50.745 1.00 123.16 ? 172 ASN B O   1 
ATOM 2796 C CB  . ASN B 2 172 ? 191.881 281.972 52.341 1.00 123.47 ? 172 ASN B CB  1 
ATOM 2797 C CG  . ASN B 2 172 ? 193.198 282.539 51.860 1.00 126.36 ? 172 ASN B CG  1 
ATOM 2798 O OD1 . ASN B 2 172 ? 193.975 281.817 51.222 1.00 128.32 ? 172 ASN B OD1 1 
ATOM 2799 N ND2 . ASN B 2 172 ? 193.453 283.822 52.096 1.00 126.10 ? 172 ASN B ND2 1 
ATOM 2800 N N   . TYR B 2 173 ? 188.517 281.635 52.096 1.00 121.61 ? 173 TYR B N   1 
ATOM 2801 C CA  . TYR B 2 173 ? 187.364 280.750 52.104 1.00 121.22 ? 173 TYR B CA  1 
ATOM 2802 C C   . TYR B 2 173 ? 186.234 281.328 51.248 1.00 122.90 ? 173 TYR B C   1 
ATOM 2803 O O   . TYR B 2 173 ? 185.135 280.771 51.234 1.00 122.82 ? 173 TYR B O   1 
ATOM 2804 C CB  . TYR B 2 173 ? 186.972 280.486 53.559 1.00 118.93 ? 173 TYR B CB  1 
ATOM 2805 C CG  . TYR B 2 173 ? 187.952 279.573 54.282 1.00 117.19 ? 173 TYR B CG  1 
ATOM 2806 C CD1 . TYR B 2 173 ? 187.913 278.193 54.104 1.00 116.10 ? 173 TYR B CD1 1 
ATOM 2807 C CD2 . TYR B 2 173 ? 188.923 280.093 55.129 1.00 116.16 ? 173 TYR B CD2 1 
ATOM 2808 C CE1 . TYR B 2 173 ? 188.801 277.354 54.756 1.00 114.22 ? 173 TYR B CE1 1 
ATOM 2809 C CE2 . TYR B 2 173 ? 189.824 279.264 55.780 1.00 114.74 ? 173 TYR B CE2 1 
ATOM 2810 C CZ  . TYR B 2 173 ? 189.759 277.892 55.596 1.00 114.81 ? 173 TYR B CZ  1 
ATOM 2811 O OH  . TYR B 2 173 ? 190.633 277.058 56.231 1.00 112.25 ? 173 TYR B OH  1 
ATOM 2812 N N   . ASN B 2 174 ? 186.516 282.422 50.522 1.00 123.49 ? 174 ASN B N   1 
ATOM 2813 C CA  . ASN B 2 174 ? 185.598 283.026 49.559 1.00 124.33 ? 174 ASN B CA  1 
ATOM 2814 C C   . ASN B 2 174 ? 184.263 283.356 50.225 1.00 122.45 ? 174 ASN B C   1 
ATOM 2815 O O   . ASN B 2 174 ? 183.202 283.071 49.675 1.00 124.06 ? 174 ASN B O   1 
ATOM 2816 C CB  . ASN B 2 174 ? 185.431 282.164 48.308 1.00 125.02 ? 174 ASN B CB  1 
ATOM 2817 C CG  . ASN B 2 174 ? 186.725 282.030 47.537 1.00 126.82 ? 174 ASN B CG  1 
ATOM 2818 O OD1 . ASN B 2 174 ? 187.015 282.866 46.673 1.00 127.24 ? 174 ASN B OD1 1 
ATOM 2819 N ND2 . ASN B 2 174 ? 187.541 281.032 47.852 1.00 125.77 ? 174 ASN B ND2 1 
ATOM 2820 N N   . VAL B 2 175 ? 184.337 283.972 51.406 1.00 121.59 ? 175 VAL B N   1 
ATOM 2821 C CA  . VAL B 2 175 ? 183.161 284.357 52.161 1.00 121.65 ? 175 VAL B CA  1 
ATOM 2822 C C   . VAL B 2 175 ? 183.081 285.879 52.110 1.00 122.21 ? 175 VAL B C   1 
ATOM 2823 O O   . VAL B 2 175 ? 184.079 286.556 52.342 1.00 122.23 ? 175 VAL B O   1 
ATOM 2824 C CB  . VAL B 2 175 ? 183.214 283.824 53.610 1.00 120.42 ? 175 VAL B CB  1 
ATOM 2825 C CG1 . VAL B 2 175 ? 182.075 284.356 54.474 1.00 117.18 ? 175 VAL B CG1 1 
ATOM 2826 C CG2 . VAL B 2 175 ? 183.247 282.296 53.660 1.00 119.93 ? 175 VAL B CG2 1 
ATOM 2827 N N   . PRO B 2 176 ? 181.920 286.474 51.756 1.00 122.87 ? 176 PRO B N   1 
ATOM 2828 C CA  . PRO B 2 176 ? 181.736 287.920 51.903 1.00 124.05 ? 176 PRO B CA  1 
ATOM 2829 C C   . PRO B 2 176 ? 181.951 288.365 53.346 1.00 124.22 ? 176 PRO B C   1 
ATOM 2830 O O   . PRO B 2 176 ? 181.438 287.740 54.273 1.00 123.47 ? 176 PRO B O   1 
ATOM 2831 C CB  . PRO B 2 176 ? 180.294 288.172 51.440 1.00 123.99 ? 176 PRO B CB  1 
ATOM 2832 C CG  . PRO B 2 176 ? 179.980 286.985 50.554 1.00 125.09 ? 176 PRO B CG  1 
ATOM 2833 C CD  . PRO B 2 176 ? 180.757 285.814 51.140 1.00 123.38 ? 176 PRO B CD  1 
ATOM 2834 N N   . TYR B 2 177 ? 182.717 289.446 53.518 1.00 124.74 ? 177 TYR B N   1 
ATOM 2835 C CA  . TYR B 2 177 ? 182.882 290.071 54.819 1.00 125.37 ? 177 TYR B CA  1 
ATOM 2836 C C   . TYR B 2 177 ? 182.991 291.580 54.622 1.00 127.76 ? 177 TYR B C   1 
ATOM 2837 O O   . TYR B 2 177 ? 183.667 292.035 53.698 1.00 129.64 ? 177 TYR B O   1 
ATOM 2838 C CB  . TYR B 2 177 ? 184.112 289.521 55.552 1.00 124.86 ? 177 TYR B CB  1 
ATOM 2839 C CG  . TYR B 2 177 ? 184.365 290.180 56.902 1.00 124.23 ? 177 TYR B CG  1 
ATOM 2840 C CD1 . TYR B 2 177 ? 183.388 290.176 57.889 1.00 123.57 ? 177 TYR B CD1 1 
ATOM 2841 C CD2 . TYR B 2 177 ? 185.550 290.855 57.171 1.00 123.29 ? 177 TYR B CD2 1 
ATOM 2842 C CE1 . TYR B 2 177 ? 183.593 290.796 59.110 1.00 122.84 ? 177 TYR B CE1 1 
ATOM 2843 C CE2 . TYR B 2 177 ? 185.764 291.489 58.385 1.00 123.46 ? 177 TYR B CE2 1 
ATOM 2844 C CZ  . TYR B 2 177 ? 184.782 291.458 59.358 1.00 122.41 ? 177 TYR B CZ  1 
ATOM 2845 O OH  . TYR B 2 177 ? 184.969 292.073 60.562 1.00 121.00 ? 177 TYR B OH  1 
ATOM 2846 N N   . GLU B 2 178 ? 182.317 292.339 55.496 1.00 128.01 ? 178 GLU B N   1 
ATOM 2847 C CA  . GLU B 2 178 ? 182.480 293.782 55.554 1.00 131.54 ? 178 GLU B CA  1 
ATOM 2848 C C   . GLU B 2 178 ? 183.083 294.148 56.908 1.00 131.59 ? 178 GLU B C   1 
ATOM 2849 O O   . GLU B 2 178 ? 182.441 293.952 57.942 1.00 129.70 ? 178 GLU B O   1 
ATOM 2850 C CB  . GLU B 2 178 ? 181.165 294.538 55.341 1.00 133.31 ? 178 GLU B CB  1 
ATOM 2851 C CG  . GLU B 2 178 ? 180.605 294.427 53.924 1.00 134.11 ? 178 GLU B CG  1 
ATOM 2852 C CD  . GLU B 2 178 ? 179.518 295.452 53.623 1.00 138.62 ? 178 GLU B CD  1 
ATOM 2853 O OE1 . GLU B 2 178 ? 178.526 295.506 54.390 1.00 138.67 ? 178 GLU B OE1 1 
ATOM 2854 O OE2 . GLU B 2 178 ? 179.660 296.201 52.624 1.00 138.74 ? 178 GLU B OE2 1 
ATOM 2855 N N   . PRO B 2 179 ? 184.325 294.686 56.955 1.00 130.58 ? 179 PRO B N   1 
ATOM 2856 C CA  . PRO B 2 179 ? 184.942 295.060 58.228 1.00 129.56 ? 179 PRO B CA  1 
ATOM 2857 C C   . PRO B 2 179 ? 184.387 296.360 58.805 1.00 133.88 ? 179 PRO B C   1 
ATOM 2858 O O   . PRO B 2 179 ? 183.825 297.174 58.072 1.00 134.23 ? 179 PRO B O   1 
ATOM 2859 C CB  . PRO B 2 179 ? 186.424 295.172 57.847 1.00 131.24 ? 179 PRO B CB  1 
ATOM 2860 C CG  . PRO B 2 179 ? 186.404 295.656 56.415 1.00 133.39 ? 179 PRO B CG  1 
ATOM 2861 C CD  . PRO B 2 179 ? 185.200 294.960 55.801 1.00 131.67 ? 179 PRO B CD  1 
ATOM 2862 N N   . ASP B 2 180 ? 184.561 296.537 60.122 1.00 132.36 ? 180 ASP B N   1 
ATOM 2863 C CA  . ASP B 2 180 ? 184.065 297.714 60.820 1.00 137.46 ? 180 ASP B CA  1 
ATOM 2864 C C   . ASP B 2 180 ? 184.888 298.935 60.410 1.00 139.40 ? 180 ASP B C   1 
ATOM 2865 O O   . ASP B 2 180 ? 186.087 298.994 60.692 1.00 139.25 ? 180 ASP B O   1 
ATOM 2866 C CB  . ASP B 2 180 ? 184.070 297.517 62.329 1.00 136.89 ? 180 ASP B CB  1 
ATOM 2867 C CG  . ASP B 2 180 ? 183.592 298.706 63.156 1.00 140.18 ? 180 ASP B CG  1 
ATOM 2868 O OD1 . ASP B 2 180 ? 183.056 299.675 62.560 1.00 140.45 ? 180 ASP B OD1 1 
ATOM 2869 O OD2 . ASP B 2 180 ? 183.768 298.664 64.397 1.00 141.95 ? 180 ASP B OD2 1 
ATOM 2870 N N   . SER B 2 181 ? 184.218 299.917 59.782 1.00 138.68 ? 181 SER B N   1 
ATOM 2871 C CA  . SER B 2 181 ? 184.871 301.099 59.236 1.00 140.94 ? 181 SER B CA  1 
ATOM 2872 C C   . SER B 2 181 ? 185.581 301.899 60.331 1.00 141.30 ? 181 SER B C   1 
ATOM 2873 O O   . SER B 2 181 ? 186.614 302.510 60.064 1.00 141.03 ? 181 SER B O   1 
ATOM 2874 C CB  . SER B 2 181 ? 183.885 301.964 58.479 1.00 142.05 ? 181 SER B CB  1 
ATOM 2875 O OG  . SER B 2 181 ? 184.548 303.002 57.766 1.00 142.17 ? 181 SER B OG  1 
ATOM 2876 N N   . VAL B 2 182 ? 185.030 301.888 61.555 1.00 140.97 ? 182 VAL B N   1 
ATOM 2877 C CA  . VAL B 2 182 ? 185.629 302.582 62.687 1.00 141.44 ? 182 VAL B CA  1 
ATOM 2878 C C   . VAL B 2 182 ? 187.059 302.076 62.877 1.00 141.21 ? 182 VAL B C   1 
ATOM 2879 O O   . VAL B 2 182 ? 188.006 302.856 62.786 1.00 141.76 ? 182 VAL B O   1 
ATOM 2880 C CB  . VAL B 2 182 ? 184.792 302.418 63.977 1.00 141.66 ? 182 VAL B CB  1 
ATOM 2881 C CG1 . VAL B 2 182 ? 185.520 302.933 65.221 1.00 141.61 ? 182 VAL B CG1 1 
ATOM 2882 C CG2 . VAL B 2 182 ? 183.414 303.065 63.844 1.00 142.20 ? 182 VAL B CG2 1 
ATOM 2883 N N   . VAL B 2 183 ? 187.192 300.766 63.134 1.00 140.16 ? 183 VAL B N   1 
ATOM 2884 C CA  . VAL B 2 183 ? 188.472 300.145 63.443 1.00 140.72 ? 183 VAL B CA  1 
ATOM 2885 C C   . VAL B 2 183 ? 189.398 300.229 62.227 1.00 140.25 ? 183 VAL B C   1 
ATOM 2886 O O   . VAL B 2 183 ? 190.587 300.514 62.373 1.00 140.66 ? 183 VAL B O   1 
ATOM 2887 C CB  . VAL B 2 183 ? 188.258 298.691 63.918 1.00 138.79 ? 183 VAL B CB  1 
ATOM 2888 C CG1 . VAL B 2 183 ? 189.532 297.859 63.829 1.00 133.55 ? 183 VAL B CG1 1 
ATOM 2889 C CG2 . VAL B 2 183 ? 187.672 298.639 65.328 1.00 136.93 ? 183 VAL B CG2 1 
ATOM 2890 N N   . MET B 2 184 ? 188.845 299.969 61.034 1.00 139.78 ? 184 MET B N   1 
ATOM 2891 C CA  . MET B 2 184 ? 189.602 300.017 59.793 1.00 140.14 ? 184 MET B CA  1 
ATOM 2892 C C   . MET B 2 184 ? 190.074 301.441 59.497 1.00 142.08 ? 184 MET B C   1 
ATOM 2893 O O   . MET B 2 184 ? 191.114 301.621 58.867 1.00 142.00 ? 184 MET B O   1 
ATOM 2894 C CB  . MET B 2 184 ? 188.762 299.526 58.606 1.00 139.99 ? 184 MET B CB  1 
ATOM 2895 C CG  . MET B 2 184 ? 188.503 298.029 58.591 1.00 138.38 ? 184 MET B CG  1 
ATOM 2896 S SD  . MET B 2 184 ? 189.961 296.991 58.840 1.00 136.58 ? 184 MET B SD  1 
ATOM 2897 C CE  . MET B 2 184 ? 191.180 297.672 57.704 1.00 138.30 ? 184 MET B CE  1 
ATOM 2898 N N   . ALA B 2 185 ? 189.278 302.438 59.916 1.00 142.19 ? 185 ALA B N   1 
ATOM 2899 C CA  . ALA B 2 185 ? 189.642 303.843 59.786 1.00 142.87 ? 185 ALA B CA  1 
ATOM 2900 C C   . ALA B 2 185 ? 190.829 304.159 60.696 1.00 143.37 ? 185 ALA B C   1 
ATOM 2901 O O   . ALA B 2 185 ? 191.778 304.810 60.256 1.00 143.02 ? 185 ALA B O   1 
ATOM 2902 C CB  . ALA B 2 185 ? 188.456 304.738 60.098 1.00 142.92 ? 185 ALA B CB  1 
ATOM 2903 N N   . GLU B 2 186 ? 190.762 303.704 61.960 1.00 142.97 ? 186 GLU B N   1 
ATOM 2904 C CA  . GLU B 2 186 ? 191.915 303.753 62.850 1.00 143.58 ? 186 GLU B CA  1 
ATOM 2905 C C   . GLU B 2 186 ? 193.124 303.265 62.051 1.00 143.48 ? 186 GLU B C   1 
ATOM 2906 O O   . GLU B 2 186 ? 194.141 303.958 61.981 1.00 143.14 ? 186 GLU B O   1 
ATOM 2907 C CB  . GLU B 2 186 ? 191.815 302.903 64.124 1.00 143.81 ? 186 GLU B CB  1 
ATOM 2908 C CG  . GLU B 2 186 ? 190.515 303.040 64.917 1.00 143.94 ? 186 GLU B CG  1 
ATOM 2909 C CD  . GLU B 2 186 ? 190.465 302.149 66.151 1.00 143.60 ? 186 GLU B CD  1 
ATOM 2910 O OE1 . GLU B 2 186 ? 190.646 300.914 66.012 1.00 139.58 ? 186 GLU B OE1 1 
ATOM 2911 O OE2 . GLU B 2 186 ? 190.246 302.691 67.260 1.00 143.64 ? 186 GLU B OE2 1 
ATOM 2912 N N   . ALA B 2 187 ? 192.973 302.079 61.431 1.00 142.91 ? 187 ALA B N   1 
ATOM 2913 C CA  . ALA B 2 187 ? 193.960 301.519 60.517 1.00 141.64 ? 187 ALA B CA  1 
ATOM 2914 C C   . ALA B 2 187 ? 195.327 301.388 61.211 1.00 142.76 ? 187 ALA B C   1 
ATOM 2915 O O   . ALA B 2 187 ? 196.346 301.342 60.474 1.00 142.90 ? 187 ALA B O   1 
ATOM 2916 C CB  . ALA B 2 187 ? 194.035 302.364 59.252 1.00 143.11 ? 187 ALA B CB  1 
# 
