data_8V2R
# 
_entry.id   8V2R 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8V2R         pdb_00008v2r 10.2210/pdb8v2r/pdb 
WWPDB D_1000279388 ?            ?                   
EMDB  EMD-42931    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8V2R 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'CryoEM of ssDNA bound CHMP1B/IST1 copolymer assembly' 
_pdbx_database_related.db_id          EMD-42931 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 afrost@altoslabs.com          Adam   Frost          ? 'principal investigator/group leader' 0000-0003-2231-2577 
3 wes@biochem.utah.edu          Wesley Sundquist      I 'principal investigator/group leader' 0000-0001-9988-6021 
4 juan.martin_serrano@kcl.ac.uk Juan   Martin-Serrano ? 'principal investigator/group leader' 0000-0002-8183-3914 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Talledge, N.'   1 0000-0002-4603-0120 
'Laughlin, T.G.' 2 0000-0001-8943-1330 
'Alian, A.'      3 0000-0003-1901-3832 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'ESCRT-III Assembles Around Mis-segregated DNA to Engage NoCut' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Talledge, N.'       1  0000-0002-4603-0120 
primary 'Glover, J.'         2  ?                   
primary 'McCullough, J.'     3  0000-0001-6836-4394 
primary 'Alian, A.'          4  0000-0003-1901-3832 
primary 'Sadler, J.B.A.'     5  ?                   
primary 'Dempsey, N.'        6  ?                   
primary 'Laughlin, T.G.'     7  0000-0001-8943-1330 
primary 'Nguyen, H.C.'       8  0000-0002-6142-8807 
primary 'Wenzel, D.'         9  0000-0002-3605-6220 
primary 'Lalonde, M.S.'      10 ?                   
primary 'Ventimiglia, L.N.'  11 ?                   
primary 'LaJoie, D.'         12 ?                   
primary 'Iwasa, J.'          13 0000-0002-4949-7607 
primary 'Starling, T.'       14 ?                   
primary 'Padilla-Parra, S.'  15 ?                   
primary 'Ullman, K.S.'       16 0000-0003-3693-2830 
primary 'Frost, A.'          17 0000-0003-2231-2577 
primary 'Sundquist, W.I.'    18 0000-0001-9988-6021 
primary 'Martin-Serrano, J.' 19 0000-0002-8183-3914 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Charged multivesicular body protein 1b' 22108.355 1 ? M136V ? ? 
2 polymer man 'IST1 homolog'                           39796.402 1 ? ?     ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'CHMP1.5,Chromatin-modifying protein 1b,CHMP1b,Vacuolar protein sorting-associated protein 46-2,Vps46-2,hVps46-2' 
2 'hIST1,Charged multivesicular body protein 8,CHMP8,Putative MAPK-activating protein PM28'                         
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQ
TAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTVSSTTTLTTPQNQVDMLLQEMADEA
GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
;
;MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQ
TAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTVSSTTTLTTPQNQVDMLLQEMADEA
GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
;
A ? 
2 'polypeptide(L)' no no 
;MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLL
ARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKI
LVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDN
FVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
;
;MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLL
ARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKI
LVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDN
FVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
;
B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   ASN n 
1 4   MET n 
1 5   GLU n 
1 6   LYS n 
1 7   HIS n 
1 8   LEU n 
1 9   PHE n 
1 10  ASN n 
1 11  LEU n 
1 12  LYS n 
1 13  PHE n 
1 14  ALA n 
1 15  ALA n 
1 16  LYS n 
1 17  GLU n 
1 18  LEU n 
1 19  SER n 
1 20  ARG n 
1 21  SER n 
1 22  ALA n 
1 23  LYS n 
1 24  LYS n 
1 25  CYS n 
1 26  ASP n 
1 27  LYS n 
1 28  GLU n 
1 29  GLU n 
1 30  LYS n 
1 31  ALA n 
1 32  GLU n 
1 33  LYS n 
1 34  ALA n 
1 35  LYS n 
1 36  ILE n 
1 37  LYS n 
1 38  LYS n 
1 39  ALA n 
1 40  ILE n 
1 41  GLN n 
1 42  LYS n 
1 43  GLY n 
1 44  ASN n 
1 45  MET n 
1 46  GLU n 
1 47  VAL n 
1 48  ALA n 
1 49  ARG n 
1 50  ILE n 
1 51  HIS n 
1 52  ALA n 
1 53  GLU n 
1 54  ASN n 
1 55  ALA n 
1 56  ILE n 
1 57  ARG n 
1 58  GLN n 
1 59  LYS n 
1 60  ASN n 
1 61  GLN n 
1 62  ALA n 
1 63  VAL n 
1 64  ASN n 
1 65  PHE n 
1 66  LEU n 
1 67  ARG n 
1 68  MET n 
1 69  SER n 
1 70  ALA n 
1 71  ARG n 
1 72  VAL n 
1 73  ASP n 
1 74  ALA n 
1 75  VAL n 
1 76  ALA n 
1 77  ALA n 
1 78  ARG n 
1 79  VAL n 
1 80  GLN n 
1 81  THR n 
1 82  ALA n 
1 83  VAL n 
1 84  THR n 
1 85  MET n 
1 86  GLY n 
1 87  LYS n 
1 88  VAL n 
1 89  THR n 
1 90  LYS n 
1 91  SER n 
1 92  MET n 
1 93  ALA n 
1 94  GLY n 
1 95  VAL n 
1 96  VAL n 
1 97  LYS n 
1 98  SER n 
1 99  MET n 
1 100 ASP n 
1 101 ALA n 
1 102 THR n 
1 103 LEU n 
1 104 LYS n 
1 105 THR n 
1 106 MET n 
1 107 ASN n 
1 108 LEU n 
1 109 GLU n 
1 110 LYS n 
1 111 ILE n 
1 112 SER n 
1 113 ALA n 
1 114 LEU n 
1 115 MET n 
1 116 ASP n 
1 117 LYS n 
1 118 PHE n 
1 119 GLU n 
1 120 HIS n 
1 121 GLN n 
1 122 PHE n 
1 123 GLU n 
1 124 THR n 
1 125 LEU n 
1 126 ASP n 
1 127 VAL n 
1 128 GLN n 
1 129 THR n 
1 130 GLN n 
1 131 GLN n 
1 132 MET n 
1 133 GLU n 
1 134 ASP n 
1 135 THR n 
1 136 VAL n 
1 137 SER n 
1 138 SER n 
1 139 THR n 
1 140 THR n 
1 141 THR n 
1 142 LEU n 
1 143 THR n 
1 144 THR n 
1 145 PRO n 
1 146 GLN n 
1 147 ASN n 
1 148 GLN n 
1 149 VAL n 
1 150 ASP n 
1 151 MET n 
1 152 LEU n 
1 153 LEU n 
1 154 GLN n 
1 155 GLU n 
1 156 MET n 
1 157 ALA n 
1 158 ASP n 
1 159 GLU n 
1 160 ALA n 
1 161 GLY n 
1 162 LEU n 
1 163 ASP n 
1 164 LEU n 
1 165 ASN n 
1 166 MET n 
1 167 GLU n 
1 168 LEU n 
1 169 PRO n 
1 170 GLN n 
1 171 GLY n 
1 172 GLN n 
1 173 THR n 
1 174 GLY n 
1 175 SER n 
1 176 VAL n 
1 177 GLY n 
1 178 THR n 
1 179 SER n 
1 180 VAL n 
1 181 ALA n 
1 182 SER n 
1 183 ALA n 
1 184 GLU n 
1 185 GLN n 
1 186 ASP n 
1 187 GLU n 
1 188 LEU n 
1 189 SER n 
1 190 GLN n 
1 191 ARG n 
1 192 LEU n 
1 193 ALA n 
1 194 ARG n 
1 195 LEU n 
1 196 ARG n 
1 197 ASP n 
1 198 GLN n 
1 199 VAL n 
2 1   MET n 
2 2   LEU n 
2 3   GLY n 
2 4   SER n 
2 5   GLY n 
2 6   PHE n 
2 7   LYS n 
2 8   ALA n 
2 9   GLU n 
2 10  ARG n 
2 11  LEU n 
2 12  ARG n 
2 13  VAL n 
2 14  ASN n 
2 15  LEU n 
2 16  ARG n 
2 17  LEU n 
2 18  VAL n 
2 19  ILE n 
2 20  ASN n 
2 21  ARG n 
2 22  LEU n 
2 23  LYS n 
2 24  LEU n 
2 25  LEU n 
2 26  GLU n 
2 27  LYS n 
2 28  LYS n 
2 29  LYS n 
2 30  THR n 
2 31  GLU n 
2 32  LEU n 
2 33  ALA n 
2 34  GLN n 
2 35  LYS n 
2 36  ALA n 
2 37  ARG n 
2 38  LYS n 
2 39  GLU n 
2 40  ILE n 
2 41  ALA n 
2 42  ASP n 
2 43  TYR n 
2 44  LEU n 
2 45  ALA n 
2 46  ALA n 
2 47  GLY n 
2 48  LYS n 
2 49  ASP n 
2 50  GLU n 
2 51  ARG n 
2 52  ALA n 
2 53  ARG n 
2 54  ILE n 
2 55  ARG n 
2 56  VAL n 
2 57  GLU n 
2 58  HIS n 
2 59  ILE n 
2 60  ILE n 
2 61  ARG n 
2 62  GLU n 
2 63  ASP n 
2 64  TYR n 
2 65  LEU n 
2 66  VAL n 
2 67  GLU n 
2 68  ALA n 
2 69  MET n 
2 70  GLU n 
2 71  ILE n 
2 72  LEU n 
2 73  GLU n 
2 74  LEU n 
2 75  TYR n 
2 76  CYS n 
2 77  ASP n 
2 78  LEU n 
2 79  LEU n 
2 80  LEU n 
2 81  ALA n 
2 82  ARG n 
2 83  PHE n 
2 84  GLY n 
2 85  LEU n 
2 86  ILE n 
2 87  GLN n 
2 88  SER n 
2 89  MET n 
2 90  LYS n 
2 91  GLU n 
2 92  LEU n 
2 93  ASP n 
2 94  SER n 
2 95  GLY n 
2 96  LEU n 
2 97  ALA n 
2 98  GLU n 
2 99  SER n 
2 100 VAL n 
2 101 SER n 
2 102 THR n 
2 103 LEU n 
2 104 ILE n 
2 105 TRP n 
2 106 ALA n 
2 107 ALA n 
2 108 PRO n 
2 109 ARG n 
2 110 LEU n 
2 111 GLN n 
2 112 SER n 
2 113 GLU n 
2 114 VAL n 
2 115 ALA n 
2 116 GLU n 
2 117 LEU n 
2 118 LYS n 
2 119 ILE n 
2 120 VAL n 
2 121 ALA n 
2 122 ASP n 
2 123 GLN n 
2 124 LEU n 
2 125 CYS n 
2 126 ALA n 
2 127 LYS n 
2 128 TYR n 
2 129 SER n 
2 130 LYS n 
2 131 GLU n 
2 132 TYR n 
2 133 GLY n 
2 134 LYS n 
2 135 LEU n 
2 136 CYS n 
2 137 ARG n 
2 138 THR n 
2 139 ASN n 
2 140 GLN n 
2 141 ILE n 
2 142 GLY n 
2 143 THR n 
2 144 VAL n 
2 145 ASN n 
2 146 ASP n 
2 147 ARG n 
2 148 LEU n 
2 149 MET n 
2 150 HIS n 
2 151 LYS n 
2 152 LEU n 
2 153 SER n 
2 154 VAL n 
2 155 GLU n 
2 156 ALA n 
2 157 PRO n 
2 158 PRO n 
2 159 LYS n 
2 160 ILE n 
2 161 LEU n 
2 162 VAL n 
2 163 GLU n 
2 164 ARG n 
2 165 TYR n 
2 166 LEU n 
2 167 ILE n 
2 168 GLU n 
2 169 ILE n 
2 170 ALA n 
2 171 LYS n 
2 172 ASN n 
2 173 TYR n 
2 174 ASN n 
2 175 VAL n 
2 176 PRO n 
2 177 TYR n 
2 178 GLU n 
2 179 PRO n 
2 180 ASP n 
2 181 SER n 
2 182 VAL n 
2 183 VAL n 
2 184 MET n 
2 185 ALA n 
2 186 GLU n 
2 187 ALA n 
2 188 PRO n 
2 189 PRO n 
2 190 GLY n 
2 191 VAL n 
2 192 GLU n 
2 193 THR n 
2 194 ASP n 
2 195 LEU n 
2 196 ILE n 
2 197 ASP n 
2 198 VAL n 
2 199 GLY n 
2 200 PHE n 
2 201 THR n 
2 202 ASP n 
2 203 ASP n 
2 204 VAL n 
2 205 LYS n 
2 206 LYS n 
2 207 GLY n 
2 208 GLY n 
2 209 PRO n 
2 210 GLY n 
2 211 ARG n 
2 212 GLY n 
2 213 GLY n 
2 214 SER n 
2 215 GLY n 
2 216 GLY n 
2 217 PHE n 
2 218 THR n 
2 219 ALA n 
2 220 PRO n 
2 221 VAL n 
2 222 GLY n 
2 223 GLY n 
2 224 PRO n 
2 225 ASP n 
2 226 GLY n 
2 227 THR n 
2 228 VAL n 
2 229 PRO n 
2 230 MET n 
2 231 PRO n 
2 232 MET n 
2 233 PRO n 
2 234 MET n 
2 235 PRO n 
2 236 MET n 
2 237 PRO n 
2 238 SER n 
2 239 ALA n 
2 240 ASN n 
2 241 THR n 
2 242 PRO n 
2 243 PHE n 
2 244 SER n 
2 245 TYR n 
2 246 PRO n 
2 247 LEU n 
2 248 PRO n 
2 249 LYS n 
2 250 GLY n 
2 251 PRO n 
2 252 SER n 
2 253 ASP n 
2 254 PHE n 
2 255 ASN n 
2 256 GLY n 
2 257 LEU n 
2 258 PRO n 
2 259 MET n 
2 260 GLY n 
2 261 THR n 
2 262 TYR n 
2 263 GLN n 
2 264 ALA n 
2 265 PHE n 
2 266 PRO n 
2 267 ASN n 
2 268 ILE n 
2 269 HIS n 
2 270 PRO n 
2 271 PRO n 
2 272 GLN n 
2 273 ILE n 
2 274 PRO n 
2 275 ALA n 
2 276 THR n 
2 277 PRO n 
2 278 PRO n 
2 279 SER n 
2 280 TYR n 
2 281 GLU n 
2 282 SER n 
2 283 VAL n 
2 284 ASP n 
2 285 ASP n 
2 286 ILE n 
2 287 ASN n 
2 288 ALA n 
2 289 ASP n 
2 290 LYS n 
2 291 ASN n 
2 292 ILE n 
2 293 SER n 
2 294 SER n 
2 295 ALA n 
2 296 GLN n 
2 297 ILE n 
2 298 VAL n 
2 299 GLY n 
2 300 PRO n 
2 301 GLY n 
2 302 PRO n 
2 303 LYS n 
2 304 PRO n 
2 305 GLU n 
2 306 ALA n 
2 307 SER n 
2 308 ALA n 
2 309 LYS n 
2 310 LEU n 
2 311 PRO n 
2 312 SER n 
2 313 ARG n 
2 314 PRO n 
2 315 ALA n 
2 316 ASP n 
2 317 ASN n 
2 318 TYR n 
2 319 ASP n 
2 320 ASN n 
2 321 PHE n 
2 322 VAL n 
2 323 LEU n 
2 324 PRO n 
2 325 GLU n 
2 326 LEU n 
2 327 PRO n 
2 328 SER n 
2 329 VAL n 
2 330 PRO n 
2 331 ASP n 
2 332 THR n 
2 333 LEU n 
2 334 PRO n 
2 335 THR n 
2 336 ALA n 
2 337 SER n 
2 338 ALA n 
2 339 GLY n 
2 340 ALA n 
2 341 SER n 
2 342 THR n 
2 343 SER n 
2 344 ALA n 
2 345 SER n 
2 346 GLU n 
2 347 ASP n 
2 348 ILE n 
2 349 ASP n 
2 350 PHE n 
2 351 ASP n 
2 352 ASP n 
2 353 LEU n 
2 354 SER n 
2 355 ARG n 
2 356 ARG n 
2 357 PHE n 
2 358 GLU n 
2 359 GLU n 
2 360 LEU n 
2 361 LYS n 
2 362 LYS n 
2 363 LYS n 
2 364 THR n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 199 human ? 'CHMP1B, C18orf2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? Plasmid ? 6xHIS-SUMO_CHMP1B ? 'pET28a(+)' ? ? 
2 1 sample 'Biological sequence' 1 364 human ? 'IST1, KIAA0174'  ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? Plasmid ? 6xHIS-SUMO_IST1   ? 'pET28c(+)' ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   SER 2   2   2   SER SER A . n 
A 1 3   ASN 3   3   3   ASN ASN A . n 
A 1 4   MET 4   4   4   MET MET A . n 
A 1 5   GLU 5   5   5   GLU GLU A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   HIS 7   7   7   HIS HIS A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   PHE 9   9   9   PHE PHE A . n 
A 1 10  ASN 10  10  10  ASN ASN A . n 
A 1 11  LEU 11  11  11  LEU LEU A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  PHE 13  13  13  PHE PHE A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  ALA 15  15  15  ALA ALA A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  GLU 17  17  17  GLU GLU A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  SER 19  19  19  SER SER A . n 
A 1 20  ARG 20  20  20  ARG ARG A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  LYS 23  23  23  LYS LYS A . n 
A 1 24  LYS 24  24  24  LYS LYS A . n 
A 1 25  CYS 25  25  25  CYS CYS A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  LYS 27  27  27  LYS LYS A . n 
A 1 28  GLU 28  28  28  GLU GLU A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  LYS 30  30  30  LYS LYS A . n 
A 1 31  ALA 31  31  31  ALA ALA A . n 
A 1 32  GLU 32  32  32  GLU GLU A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  ALA 34  34  34  ALA ALA A . n 
A 1 35  LYS 35  35  35  LYS LYS A . n 
A 1 36  ILE 36  36  36  ILE ILE A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  LYS 38  38  38  LYS LYS A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  GLN 41  41  41  GLN GLN A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  GLY 43  43  43  GLY GLY A . n 
A 1 44  ASN 44  44  44  ASN ASN A . n 
A 1 45  MET 45  45  45  MET MET A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  VAL 47  47  47  VAL VAL A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  GLU 53  53  53  GLU GLU A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  ILE 56  56  56  ILE ILE A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  LYS 59  59  59  LYS LYS A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  GLN 61  61  61  GLN GLN A . n 
A 1 62  ALA 62  62  62  ALA ALA A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  PHE 65  65  65  PHE PHE A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  MET 68  68  68  MET MET A . n 
A 1 69  SER 69  69  69  SER SER A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  ARG 71  71  71  ARG ARG A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  ASP 73  73  73  ASP ASP A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  VAL 75  75  75  VAL VAL A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  GLN 80  80  80  GLN GLN A . n 
A 1 81  THR 81  81  81  THR THR A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  THR 84  84  84  THR THR A . n 
A 1 85  MET 85  85  85  MET MET A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  LYS 87  87  87  LYS LYS A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  SER 91  91  91  SER SER A . n 
A 1 92  MET 92  92  92  MET MET A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  GLY 94  94  94  GLY GLY A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  SER 98  98  98  SER SER A . n 
A 1 99  MET 99  99  99  MET MET A . n 
A 1 100 ASP 100 100 100 ASP ASP A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 LYS 104 104 104 LYS LYS A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 MET 106 106 106 MET MET A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 LYS 110 110 110 LYS LYS A . n 
A 1 111 ILE 111 111 111 ILE ILE A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 MET 115 115 115 MET MET A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 LYS 117 117 117 LYS LYS A . n 
A 1 118 PHE 118 118 118 PHE PHE A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 HIS 120 120 120 HIS HIS A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 LEU 125 125 125 LEU LEU A . n 
A 1 126 ASP 126 126 126 ASP ASP A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 GLN 128 128 128 GLN GLN A . n 
A 1 129 THR 129 129 129 THR THR A . n 
A 1 130 GLN 130 130 130 GLN GLN A . n 
A 1 131 GLN 131 131 131 GLN GLN A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 ASP 134 134 134 ASP ASP A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 VAL 136 136 136 VAL VAL A . n 
A 1 137 SER 137 137 137 SER SER A . n 
A 1 138 SER 138 138 138 SER SER A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 THR 140 140 140 THR THR A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 PRO 145 145 145 PRO PRO A . n 
A 1 146 GLN 146 146 146 GLN GLN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 VAL 149 149 149 VAL VAL A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 MET 151 151 151 MET MET A . n 
A 1 152 LEU 152 152 152 LEU LEU A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 GLN 154 154 154 GLN GLN A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 MET 156 156 156 MET MET A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 ASP 158 158 158 ASP ASP A . n 
A 1 159 GLU 159 159 159 GLU GLU A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 LEU 162 162 162 LEU LEU A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 LEU 164 164 164 LEU LEU A . n 
A 1 165 ASN 165 165 165 ASN ASN A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 GLU 167 167 167 GLU GLU A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 PRO 169 169 169 PRO PRO A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 GLY 171 171 ?   ?   ?   A . n 
A 1 172 GLN 172 172 ?   ?   ?   A . n 
A 1 173 THR 173 173 ?   ?   ?   A . n 
A 1 174 GLY 174 174 ?   ?   ?   A . n 
A 1 175 SER 175 175 ?   ?   ?   A . n 
A 1 176 VAL 176 176 ?   ?   ?   A . n 
A 1 177 GLY 177 177 ?   ?   ?   A . n 
A 1 178 THR 178 178 ?   ?   ?   A . n 
A 1 179 SER 179 179 ?   ?   ?   A . n 
A 1 180 VAL 180 180 ?   ?   ?   A . n 
A 1 181 ALA 181 181 ?   ?   ?   A . n 
A 1 182 SER 182 182 ?   ?   ?   A . n 
A 1 183 ALA 183 183 ?   ?   ?   A . n 
A 1 184 GLU 184 184 ?   ?   ?   A . n 
A 1 185 GLN 185 185 ?   ?   ?   A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 GLU 187 187 187 GLU GLU A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 SER 189 189 189 SER SER A . n 
A 1 190 GLN 190 190 190 GLN GLN A . n 
A 1 191 ARG 191 191 191 ARG ARG A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 ARG 196 196 196 ARG ARG A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 GLN 198 198 198 GLN GLN A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   LEU 2   2   ?   ?   ?   B . n 
B 2 3   GLY 3   3   ?   ?   ?   B . n 
B 2 4   SER 4   4   4   SER SER B . n 
B 2 5   GLY 5   5   5   GLY GLY B . n 
B 2 6   PHE 6   6   6   PHE PHE B . n 
B 2 7   LYS 7   7   7   LYS LYS B . n 
B 2 8   ALA 8   8   8   ALA ALA B . n 
B 2 9   GLU 9   9   9   GLU GLU B . n 
B 2 10  ARG 10  10  10  ARG ARG B . n 
B 2 11  LEU 11  11  11  LEU LEU B . n 
B 2 12  ARG 12  12  12  ARG ARG B . n 
B 2 13  VAL 13  13  13  VAL VAL B . n 
B 2 14  ASN 14  14  14  ASN ASN B . n 
B 2 15  LEU 15  15  15  LEU LEU B . n 
B 2 16  ARG 16  16  16  ARG ARG B . n 
B 2 17  LEU 17  17  17  LEU LEU B . n 
B 2 18  VAL 18  18  18  VAL VAL B . n 
B 2 19  ILE 19  19  19  ILE ILE B . n 
B 2 20  ASN 20  20  20  ASN ASN B . n 
B 2 21  ARG 21  21  21  ARG ARG B . n 
B 2 22  LEU 22  22  22  LEU LEU B . n 
B 2 23  LYS 23  23  23  LYS LYS B . n 
B 2 24  LEU 24  24  24  LEU LEU B . n 
B 2 25  LEU 25  25  25  LEU LEU B . n 
B 2 26  GLU 26  26  26  GLU GLU B . n 
B 2 27  LYS 27  27  27  LYS LYS B . n 
B 2 28  LYS 28  28  28  LYS LYS B . n 
B 2 29  LYS 29  29  29  LYS LYS B . n 
B 2 30  THR 30  30  30  THR THR B . n 
B 2 31  GLU 31  31  31  GLU GLU B . n 
B 2 32  LEU 32  32  32  LEU LEU B . n 
B 2 33  ALA 33  33  33  ALA ALA B . n 
B 2 34  GLN 34  34  34  GLN GLN B . n 
B 2 35  LYS 35  35  35  LYS LYS B . n 
B 2 36  ALA 36  36  36  ALA ALA B . n 
B 2 37  ARG 37  37  37  ARG ARG B . n 
B 2 38  LYS 38  38  38  LYS LYS B . n 
B 2 39  GLU 39  39  39  GLU GLU B . n 
B 2 40  ILE 40  40  40  ILE ILE B . n 
B 2 41  ALA 41  41  41  ALA ALA B . n 
B 2 42  ASP 42  42  42  ASP ASP B . n 
B 2 43  TYR 43  43  43  TYR TYR B . n 
B 2 44  LEU 44  44  44  LEU LEU B . n 
B 2 45  ALA 45  45  45  ALA ALA B . n 
B 2 46  ALA 46  46  46  ALA ALA B . n 
B 2 47  GLY 47  47  47  GLY GLY B . n 
B 2 48  LYS 48  48  48  LYS LYS B . n 
B 2 49  ASP 49  49  49  ASP ASP B . n 
B 2 50  GLU 50  50  50  GLU GLU B . n 
B 2 51  ARG 51  51  51  ARG ARG B . n 
B 2 52  ALA 52  52  52  ALA ALA B . n 
B 2 53  ARG 53  53  53  ARG ARG B . n 
B 2 54  ILE 54  54  54  ILE ILE B . n 
B 2 55  ARG 55  55  55  ARG ARG B . n 
B 2 56  VAL 56  56  56  VAL VAL B . n 
B 2 57  GLU 57  57  57  GLU GLU B . n 
B 2 58  HIS 58  58  58  HIS HIS B . n 
B 2 59  ILE 59  59  59  ILE ILE B . n 
B 2 60  ILE 60  60  60  ILE ILE B . n 
B 2 61  ARG 61  61  61  ARG ARG B . n 
B 2 62  GLU 62  62  62  GLU GLU B . n 
B 2 63  ASP 63  63  63  ASP ASP B . n 
B 2 64  TYR 64  64  64  TYR TYR B . n 
B 2 65  LEU 65  65  65  LEU LEU B . n 
B 2 66  VAL 66  66  66  VAL VAL B . n 
B 2 67  GLU 67  67  67  GLU GLU B . n 
B 2 68  ALA 68  68  68  ALA ALA B . n 
B 2 69  MET 69  69  69  MET MET B . n 
B 2 70  GLU 70  70  70  GLU GLU B . n 
B 2 71  ILE 71  71  71  ILE ILE B . n 
B 2 72  LEU 72  72  72  LEU LEU B . n 
B 2 73  GLU 73  73  73  GLU GLU B . n 
B 2 74  LEU 74  74  74  LEU LEU B . n 
B 2 75  TYR 75  75  75  TYR TYR B . n 
B 2 76  CYS 76  76  76  CYS CYS B . n 
B 2 77  ASP 77  77  77  ASP ASP B . n 
B 2 78  LEU 78  78  78  LEU LEU B . n 
B 2 79  LEU 79  79  79  LEU LEU B . n 
B 2 80  LEU 80  80  80  LEU LEU B . n 
B 2 81  ALA 81  81  81  ALA ALA B . n 
B 2 82  ARG 82  82  82  ARG ARG B . n 
B 2 83  PHE 83  83  83  PHE PHE B . n 
B 2 84  GLY 84  84  84  GLY GLY B . n 
B 2 85  LEU 85  85  85  LEU LEU B . n 
B 2 86  ILE 86  86  86  ILE ILE B . n 
B 2 87  GLN 87  87  87  GLN GLN B . n 
B 2 88  SER 88  88  88  SER SER B . n 
B 2 89  MET 89  89  89  MET MET B . n 
B 2 90  LYS 90  90  90  LYS LYS B . n 
B 2 91  GLU 91  91  91  GLU GLU B . n 
B 2 92  LEU 92  92  92  LEU LEU B . n 
B 2 93  ASP 93  93  93  ASP ASP B . n 
B 2 94  SER 94  94  94  SER SER B . n 
B 2 95  GLY 95  95  95  GLY GLY B . n 
B 2 96  LEU 96  96  96  LEU LEU B . n 
B 2 97  ALA 97  97  97  ALA ALA B . n 
B 2 98  GLU 98  98  98  GLU GLU B . n 
B 2 99  SER 99  99  99  SER SER B . n 
B 2 100 VAL 100 100 100 VAL VAL B . n 
B 2 101 SER 101 101 101 SER SER B . n 
B 2 102 THR 102 102 102 THR THR B . n 
B 2 103 LEU 103 103 103 LEU LEU B . n 
B 2 104 ILE 104 104 104 ILE ILE B . n 
B 2 105 TRP 105 105 105 TRP TRP B . n 
B 2 106 ALA 106 106 106 ALA ALA B . n 
B 2 107 ALA 107 107 107 ALA ALA B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 ARG 109 109 109 ARG ARG B . n 
B 2 110 LEU 110 110 110 LEU LEU B . n 
B 2 111 GLN 111 111 111 GLN GLN B . n 
B 2 112 SER 112 112 112 SER SER B . n 
B 2 113 GLU 113 113 113 GLU GLU B . n 
B 2 114 VAL 114 114 114 VAL VAL B . n 
B 2 115 ALA 115 115 115 ALA ALA B . n 
B 2 116 GLU 116 116 116 GLU GLU B . n 
B 2 117 LEU 117 117 117 LEU LEU B . n 
B 2 118 LYS 118 118 118 LYS LYS B . n 
B 2 119 ILE 119 119 119 ILE ILE B . n 
B 2 120 VAL 120 120 120 VAL VAL B . n 
B 2 121 ALA 121 121 121 ALA ALA B . n 
B 2 122 ASP 122 122 122 ASP ASP B . n 
B 2 123 GLN 123 123 123 GLN GLN B . n 
B 2 124 LEU 124 124 124 LEU LEU B . n 
B 2 125 CYS 125 125 125 CYS CYS B . n 
B 2 126 ALA 126 126 126 ALA ALA B . n 
B 2 127 LYS 127 127 127 LYS LYS B . n 
B 2 128 TYR 128 128 128 TYR TYR B . n 
B 2 129 SER 129 129 129 SER SER B . n 
B 2 130 LYS 130 130 130 LYS LYS B . n 
B 2 131 GLU 131 131 131 GLU GLU B . n 
B 2 132 TYR 132 132 132 TYR TYR B . n 
B 2 133 GLY 133 133 133 GLY GLY B . n 
B 2 134 LYS 134 134 134 LYS LYS B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 CYS 136 136 136 CYS CYS B . n 
B 2 137 ARG 137 137 137 ARG ARG B . n 
B 2 138 THR 138 138 138 THR THR B . n 
B 2 139 ASN 139 139 139 ASN ASN B . n 
B 2 140 GLN 140 140 140 GLN GLN B . n 
B 2 141 ILE 141 141 141 ILE ILE B . n 
B 2 142 GLY 142 142 142 GLY GLY B . n 
B 2 143 THR 143 143 143 THR THR B . n 
B 2 144 VAL 144 144 144 VAL VAL B . n 
B 2 145 ASN 145 145 145 ASN ASN B . n 
B 2 146 ASP 146 146 146 ASP ASP B . n 
B 2 147 ARG 147 147 147 ARG ARG B . n 
B 2 148 LEU 148 148 148 LEU LEU B . n 
B 2 149 MET 149 149 149 MET MET B . n 
B 2 150 HIS 150 150 150 HIS HIS B . n 
B 2 151 LYS 151 151 151 LYS LYS B . n 
B 2 152 LEU 152 152 152 LEU LEU B . n 
B 2 153 SER 153 153 153 SER SER B . n 
B 2 154 VAL 154 154 154 VAL VAL B . n 
B 2 155 GLU 155 155 155 GLU GLU B . n 
B 2 156 ALA 156 156 156 ALA ALA B . n 
B 2 157 PRO 157 157 157 PRO PRO B . n 
B 2 158 PRO 158 158 158 PRO PRO B . n 
B 2 159 LYS 159 159 159 LYS LYS B . n 
B 2 160 ILE 160 160 160 ILE ILE B . n 
B 2 161 LEU 161 161 161 LEU LEU B . n 
B 2 162 VAL 162 162 162 VAL VAL B . n 
B 2 163 GLU 163 163 163 GLU GLU B . n 
B 2 164 ARG 164 164 164 ARG ARG B . n 
B 2 165 TYR 165 165 165 TYR TYR B . n 
B 2 166 LEU 166 166 166 LEU LEU B . n 
B 2 167 ILE 167 167 167 ILE ILE B . n 
B 2 168 GLU 168 168 168 GLU GLU B . n 
B 2 169 ILE 169 169 169 ILE ILE B . n 
B 2 170 ALA 170 170 170 ALA ALA B . n 
B 2 171 LYS 171 171 171 LYS LYS B . n 
B 2 172 ASN 172 172 172 ASN ASN B . n 
B 2 173 TYR 173 173 173 TYR TYR B . n 
B 2 174 ASN 174 174 174 ASN ASN B . n 
B 2 175 VAL 175 175 175 VAL VAL B . n 
B 2 176 PRO 176 176 176 PRO PRO B . n 
B 2 177 TYR 177 177 177 TYR TYR B . n 
B 2 178 GLU 178 178 178 GLU GLU B . n 
B 2 179 PRO 179 179 179 PRO PRO B . n 
B 2 180 ASP 180 180 180 ASP ASP B . n 
B 2 181 SER 181 181 181 SER SER B . n 
B 2 182 VAL 182 182 182 VAL VAL B . n 
B 2 183 VAL 183 183 183 VAL VAL B . n 
B 2 184 MET 184 184 184 MET MET B . n 
B 2 185 ALA 185 185 185 ALA ALA B . n 
B 2 186 GLU 186 186 186 GLU GLU B . n 
B 2 187 ALA 187 187 187 ALA ALA B . n 
B 2 188 PRO 188 188 ?   ?   ?   B . n 
B 2 189 PRO 189 189 ?   ?   ?   B . n 
B 2 190 GLY 190 190 ?   ?   ?   B . n 
B 2 191 VAL 191 191 ?   ?   ?   B . n 
B 2 192 GLU 192 192 ?   ?   ?   B . n 
B 2 193 THR 193 193 ?   ?   ?   B . n 
B 2 194 ASP 194 194 ?   ?   ?   B . n 
B 2 195 LEU 195 195 ?   ?   ?   B . n 
B 2 196 ILE 196 196 ?   ?   ?   B . n 
B 2 197 ASP 197 197 ?   ?   ?   B . n 
B 2 198 VAL 198 198 ?   ?   ?   B . n 
B 2 199 GLY 199 199 ?   ?   ?   B . n 
B 2 200 PHE 200 200 ?   ?   ?   B . n 
B 2 201 THR 201 201 ?   ?   ?   B . n 
B 2 202 ASP 202 202 ?   ?   ?   B . n 
B 2 203 ASP 203 203 ?   ?   ?   B . n 
B 2 204 VAL 204 204 ?   ?   ?   B . n 
B 2 205 LYS 205 205 ?   ?   ?   B . n 
B 2 206 LYS 206 206 ?   ?   ?   B . n 
B 2 207 GLY 207 207 ?   ?   ?   B . n 
B 2 208 GLY 208 208 ?   ?   ?   B . n 
B 2 209 PRO 209 209 ?   ?   ?   B . n 
B 2 210 GLY 210 210 ?   ?   ?   B . n 
B 2 211 ARG 211 211 ?   ?   ?   B . n 
B 2 212 GLY 212 212 ?   ?   ?   B . n 
B 2 213 GLY 213 213 ?   ?   ?   B . n 
B 2 214 SER 214 214 ?   ?   ?   B . n 
B 2 215 GLY 215 215 ?   ?   ?   B . n 
B 2 216 GLY 216 216 ?   ?   ?   B . n 
B 2 217 PHE 217 217 ?   ?   ?   B . n 
B 2 218 THR 218 218 ?   ?   ?   B . n 
B 2 219 ALA 219 219 ?   ?   ?   B . n 
B 2 220 PRO 220 220 ?   ?   ?   B . n 
B 2 221 VAL 221 221 ?   ?   ?   B . n 
B 2 222 GLY 222 222 ?   ?   ?   B . n 
B 2 223 GLY 223 223 ?   ?   ?   B . n 
B 2 224 PRO 224 224 ?   ?   ?   B . n 
B 2 225 ASP 225 225 ?   ?   ?   B . n 
B 2 226 GLY 226 226 ?   ?   ?   B . n 
B 2 227 THR 227 227 ?   ?   ?   B . n 
B 2 228 VAL 228 228 ?   ?   ?   B . n 
B 2 229 PRO 229 229 ?   ?   ?   B . n 
B 2 230 MET 230 230 ?   ?   ?   B . n 
B 2 231 PRO 231 231 ?   ?   ?   B . n 
B 2 232 MET 232 232 ?   ?   ?   B . n 
B 2 233 PRO 233 233 ?   ?   ?   B . n 
B 2 234 MET 234 234 ?   ?   ?   B . n 
B 2 235 PRO 235 235 ?   ?   ?   B . n 
B 2 236 MET 236 236 ?   ?   ?   B . n 
B 2 237 PRO 237 237 ?   ?   ?   B . n 
B 2 238 SER 238 238 ?   ?   ?   B . n 
B 2 239 ALA 239 239 ?   ?   ?   B . n 
B 2 240 ASN 240 240 ?   ?   ?   B . n 
B 2 241 THR 241 241 ?   ?   ?   B . n 
B 2 242 PRO 242 242 ?   ?   ?   B . n 
B 2 243 PHE 243 243 ?   ?   ?   B . n 
B 2 244 SER 244 244 ?   ?   ?   B . n 
B 2 245 TYR 245 245 ?   ?   ?   B . n 
B 2 246 PRO 246 246 ?   ?   ?   B . n 
B 2 247 LEU 247 247 ?   ?   ?   B . n 
B 2 248 PRO 248 248 ?   ?   ?   B . n 
B 2 249 LYS 249 249 ?   ?   ?   B . n 
B 2 250 GLY 250 250 ?   ?   ?   B . n 
B 2 251 PRO 251 251 ?   ?   ?   B . n 
B 2 252 SER 252 252 ?   ?   ?   B . n 
B 2 253 ASP 253 253 ?   ?   ?   B . n 
B 2 254 PHE 254 254 ?   ?   ?   B . n 
B 2 255 ASN 255 255 ?   ?   ?   B . n 
B 2 256 GLY 256 256 ?   ?   ?   B . n 
B 2 257 LEU 257 257 ?   ?   ?   B . n 
B 2 258 PRO 258 258 ?   ?   ?   B . n 
B 2 259 MET 259 259 ?   ?   ?   B . n 
B 2 260 GLY 260 260 ?   ?   ?   B . n 
B 2 261 THR 261 261 ?   ?   ?   B . n 
B 2 262 TYR 262 262 ?   ?   ?   B . n 
B 2 263 GLN 263 263 ?   ?   ?   B . n 
B 2 264 ALA 264 264 ?   ?   ?   B . n 
B 2 265 PHE 265 265 ?   ?   ?   B . n 
B 2 266 PRO 266 266 ?   ?   ?   B . n 
B 2 267 ASN 267 267 ?   ?   ?   B . n 
B 2 268 ILE 268 268 ?   ?   ?   B . n 
B 2 269 HIS 269 269 ?   ?   ?   B . n 
B 2 270 PRO 270 270 ?   ?   ?   B . n 
B 2 271 PRO 271 271 ?   ?   ?   B . n 
B 2 272 GLN 272 272 ?   ?   ?   B . n 
B 2 273 ILE 273 273 ?   ?   ?   B . n 
B 2 274 PRO 274 274 ?   ?   ?   B . n 
B 2 275 ALA 275 275 ?   ?   ?   B . n 
B 2 276 THR 276 276 ?   ?   ?   B . n 
B 2 277 PRO 277 277 ?   ?   ?   B . n 
B 2 278 PRO 278 278 ?   ?   ?   B . n 
B 2 279 SER 279 279 ?   ?   ?   B . n 
B 2 280 TYR 280 280 ?   ?   ?   B . n 
B 2 281 GLU 281 281 ?   ?   ?   B . n 
B 2 282 SER 282 282 ?   ?   ?   B . n 
B 2 283 VAL 283 283 ?   ?   ?   B . n 
B 2 284 ASP 284 284 ?   ?   ?   B . n 
B 2 285 ASP 285 285 ?   ?   ?   B . n 
B 2 286 ILE 286 286 ?   ?   ?   B . n 
B 2 287 ASN 287 287 ?   ?   ?   B . n 
B 2 288 ALA 288 288 ?   ?   ?   B . n 
B 2 289 ASP 289 289 ?   ?   ?   B . n 
B 2 290 LYS 290 290 ?   ?   ?   B . n 
B 2 291 ASN 291 291 ?   ?   ?   B . n 
B 2 292 ILE 292 292 ?   ?   ?   B . n 
B 2 293 SER 293 293 ?   ?   ?   B . n 
B 2 294 SER 294 294 ?   ?   ?   B . n 
B 2 295 ALA 295 295 ?   ?   ?   B . n 
B 2 296 GLN 296 296 ?   ?   ?   B . n 
B 2 297 ILE 297 297 ?   ?   ?   B . n 
B 2 298 VAL 298 298 ?   ?   ?   B . n 
B 2 299 GLY 299 299 ?   ?   ?   B . n 
B 2 300 PRO 300 300 ?   ?   ?   B . n 
B 2 301 GLY 301 301 ?   ?   ?   B . n 
B 2 302 PRO 302 302 ?   ?   ?   B . n 
B 2 303 LYS 303 303 ?   ?   ?   B . n 
B 2 304 PRO 304 304 ?   ?   ?   B . n 
B 2 305 GLU 305 305 ?   ?   ?   B . n 
B 2 306 ALA 306 306 ?   ?   ?   B . n 
B 2 307 SER 307 307 ?   ?   ?   B . n 
B 2 308 ALA 308 308 ?   ?   ?   B . n 
B 2 309 LYS 309 309 ?   ?   ?   B . n 
B 2 310 LEU 310 310 ?   ?   ?   B . n 
B 2 311 PRO 311 311 ?   ?   ?   B . n 
B 2 312 SER 312 312 ?   ?   ?   B . n 
B 2 313 ARG 313 313 ?   ?   ?   B . n 
B 2 314 PRO 314 314 ?   ?   ?   B . n 
B 2 315 ALA 315 315 ?   ?   ?   B . n 
B 2 316 ASP 316 316 ?   ?   ?   B . n 
B 2 317 ASN 317 317 ?   ?   ?   B . n 
B 2 318 TYR 318 318 ?   ?   ?   B . n 
B 2 319 ASP 319 319 ?   ?   ?   B . n 
B 2 320 ASN 320 320 ?   ?   ?   B . n 
B 2 321 PHE 321 321 ?   ?   ?   B . n 
B 2 322 VAL 322 322 ?   ?   ?   B . n 
B 2 323 LEU 323 323 ?   ?   ?   B . n 
B 2 324 PRO 324 324 ?   ?   ?   B . n 
B 2 325 GLU 325 325 ?   ?   ?   B . n 
B 2 326 LEU 326 326 ?   ?   ?   B . n 
B 2 327 PRO 327 327 ?   ?   ?   B . n 
B 2 328 SER 328 328 ?   ?   ?   B . n 
B 2 329 VAL 329 329 ?   ?   ?   B . n 
B 2 330 PRO 330 330 ?   ?   ?   B . n 
B 2 331 ASP 331 331 ?   ?   ?   B . n 
B 2 332 THR 332 332 ?   ?   ?   B . n 
B 2 333 LEU 333 333 ?   ?   ?   B . n 
B 2 334 PRO 334 334 ?   ?   ?   B . n 
B 2 335 THR 335 335 ?   ?   ?   B . n 
B 2 336 ALA 336 336 ?   ?   ?   B . n 
B 2 337 SER 337 337 ?   ?   ?   B . n 
B 2 338 ALA 338 338 ?   ?   ?   B . n 
B 2 339 GLY 339 339 ?   ?   ?   B . n 
B 2 340 ALA 340 340 ?   ?   ?   B . n 
B 2 341 SER 341 341 ?   ?   ?   B . n 
B 2 342 THR 342 342 ?   ?   ?   B . n 
B 2 343 SER 343 343 ?   ?   ?   B . n 
B 2 344 ALA 344 344 ?   ?   ?   B . n 
B 2 345 SER 345 345 ?   ?   ?   B . n 
B 2 346 GLU 346 346 ?   ?   ?   B . n 
B 2 347 ASP 347 347 ?   ?   ?   B . n 
B 2 348 ILE 348 348 ?   ?   ?   B . n 
B 2 349 ASP 349 349 ?   ?   ?   B . n 
B 2 350 PHE 350 350 ?   ?   ?   B . n 
B 2 351 ASP 351 351 ?   ?   ?   B . n 
B 2 352 ASP 352 352 ?   ?   ?   B . n 
B 2 353 LEU 353 353 ?   ?   ?   B . n 
B 2 354 SER 354 354 ?   ?   ?   B . n 
B 2 355 ARG 355 355 ?   ?   ?   B . n 
B 2 356 ARG 356 356 ?   ?   ?   B . n 
B 2 357 PHE 357 357 ?   ?   ?   B . n 
B 2 358 GLU 358 358 ?   ?   ?   B . n 
B 2 359 GLU 359 359 ?   ?   ?   B . n 
B 2 360 LEU 360 360 ?   ?   ?   B . n 
B 2 361 LYS 361 361 ?   ?   ?   B . n 
B 2 362 LYS 362 362 ?   ?   ?   B . n 
B 2 363 LYS 363 363 ?   ?   ?   B . n 
B 2 364 THR 364 364 ?   ?   ?   B . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8V2R 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8V2R 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8V2R 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8V2R 
_struct.title                        'CryoEM of ssDNA bound CHMP1B/IST1 copolymer assembly' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8V2R 
_struct_keywords.text            'nucleic acid binding protein in vitro, RNA BINDING PROTEIN, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CHM1B_HUMAN Q7LBR1 ? 1 
;MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQ
TAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEA
GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
;
1 
2 UNP IST1_HUMAN  P53990 ? 2 
;MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLL
ARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKI
LVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDN
FVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
;
1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8V2R A 1 ? 199 ? Q7LBR1 1 ? 199 ? 1 199 
2 2 8V2R B 1 ? 364 ? P53990 1 ? 364 ? 1 364 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8V2R 
_struct_ref_seq_dif.mon_id                       VAL 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      136 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q7LBR1 
_struct_ref_seq_dif.db_mon_id                    MET 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          136 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            136 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   192-meric 
_pdbx_struct_assembly.oligomeric_count     192 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96
;
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                
'Models are deposited as asymmetric units with the helical copies stored in the BIOMTX records.' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'point symmetry operation' ?     ?     -0.12819000 -0.99175000 0.00000000 378.87558 0.99175000  -0.12819000 0.00000000 24.38458 
0.00000000 0.00000000 1.00000000 -257.12500 
2  'point symmetry operation' ?     ?     -0.46013800 -0.88784800 0.00000000 419.63194 0.88784800  -0.46013800 0.00000000 
102.27972 0.00000000 0.00000000 1.00000000 -254.10000 
3  'point symmetry operation' ?     ?     -0.73641600 -0.67652900 0.00000000 431.24153 0.67652900  -0.73641600 0.00000000 
189.42300 0.00000000 0.00000000 1.00000000 -251.07500 
4  'point symmetry operation' ?     ?     -0.92359900 -0.38336100 0.00000000 412.29977 0.38336100  -0.92359900 0.00000000 
275.27137 0.00000000 0.00000000 1.00000000 -248.05000 
5  'point symmetry operation' ?     ?     -0.99904000 -0.04381100 0.00000000 365.09833 0.04381100  -0.99904000 0.00000000 
349.43846 0.00000000 0.00000000 1.00000000 -245.02500 
6  'point symmetry operation' ?     ?     -0.95361200 0.30103900  0.00000000 295.34789 -0.30103900 -0.95361200 0.00000000 
402.95116 0.00000000 0.00000000 1.00000000 -242.00000 
7  'point symmetry operation' ?     ?     -0.79281100 0.60946700  0.00000000 211.48720 -0.60946700 -0.79281100 0.00000000 
429.33522 0.00000000 0.00000000 1.00000000 -238.97500 
8  'point symmetry operation' ?     ?     -0.53609200 0.84416000  0.00000000 123.66217 -0.84416000 -0.53609200 0.00000000 
425.39856 0.00000000 0.00000000 1.00000000 -235.95000 
9  'point symmetry operation' ?     ?     -0.21451400 0.97672100  0.00000000 42.49832  -0.97672100 -0.21451400 0.00000000 
391.61747 0.00000000 0.00000000 1.00000000 -232.92500 
10 'point symmetry operation' ?     ?     0.13301800  0.99111400  0.00000000 -22.18473 -0.99111400 0.13301800  0.00000000 
332.07894 0.00000000 0.00000000 1.00000000 -229.90000 
11 'point symmetry operation' ?     ?     0.46445600  0.88559600  0.00000000 -62.56130 -0.88559600 0.46445600  0.00000000 
253.98626 0.00000000 0.00000000 1.00000000 -226.87500 
12 'point symmetry operation' ?     ?     0.73970200  0.67293500  0.00000000 -73.74642 -0.67293500 0.73970200  0.00000000 
166.78749 0.00000000 0.00000000 1.00000000 -223.85000 
13 'point symmetry operation' ?     ?     0.92545500  0.37885900  0.00000000 -54.38685 -0.37885900 0.92545500  0.00000000 81.03237 
0.00000000 0.00000000 1.00000000 -220.82500 
14 'point symmetry operation' ?     ?     0.99924100  0.03894600  0.00000000 -6.82482  -0.03894600 0.99924100  0.00000000 7.09600 
0.00000000 0.00000000 1.00000000 -217.80000 
15 'point symmetry operation' ?     ?     0.95213500  -0.30567900 0.00000000 63.18538  0.30567900  0.95213500  0.00000000 
-46.07641 0.00000000 0.00000000 1.00000000 -214.77500 
16 'point symmetry operation' ?     ?     0.78983400  -0.61332100 0.00000000 147.17354 0.61332100  0.78983400  0.00000000 
-72.05180 0.00000000 0.00000000 1.00000000 -211.75000 
17 'point symmetry operation' ?     ?     0.53197500  -0.84676000 0.00000000 234.97836 0.84676000  0.53197500  0.00000000 
-67.68753 0.00000000 0.00000000 1.00000000 -208.72500 
18 'point symmetry operation' ?     ?     0.20975500  -0.97775400 0.00000000 315.97676 0.97775400  0.20975500  0.00000000 
-33.51162 0.00000000 0.00000000 1.00000000 -205.70000 
19 'point symmetry operation' ?     ?     -0.13784200 -0.99045400 0.00000000 380.36913 0.99045400  -0.13784200 0.00000000 26.34117 
0.00000000 0.00000000 1.00000000 -202.67500 
20 'point symmetry operation' ?     ?     -0.46876300 -0.88332400 0.00000000 420.36495 0.88332400  -0.46876300 0.00000000 
104.62954 0.00000000 0.00000000 1.00000000 -199.65000 
21 'point symmetry operation' ?     ?     -0.74297000 -0.66932500 0.00000000 431.12532 0.66932500  -0.74297000 0.00000000 
191.88174 0.00000000 0.00000000 1.00000000 -196.62500 
22 'point symmetry operation' ?     ?     -0.92728800 -0.37434800 0.00000000 411.34840 0.37434800  -0.92728800 0.00000000 
277.54157 0.00000000 0.00000000 1.00000000 -193.60000 
23 'point symmetry operation' ?     ?     -0.99941900 -0.03408000 0.00000000 363.42691 0.03408000  -0.99941900 0.00000000 
351.24546 0.00000000 0.00000000 1.00000000 -190.57500 
24 'point symmetry operation' ?     ?     -0.95063500 0.31031100  0.00000000 293.15862 -0.31031100 -0.95063500 0.00000000 
404.07634 0.00000000 0.00000000 1.00000000 -187.55000 
25 'point symmetry operation' ?     ?     -0.78683800 0.61715900  0.00000000 209.04496 -0.61715900 -0.78683800 0.00000000 
429.64245 0.00000000 0.00000000 1.00000000 -184.52500 
26 'point symmetry operation' ?     ?     -0.52784600 0.84934000  0.00000000 121.26243 -0.84934000 -0.52784600 0.00000000 
424.85067 0.00000000 0.00000000 1.00000000 -181.50000 
27 'point symmetry operation' ?     ?     -0.20499100 0.97876400  0.00000000 40.43142  -0.97876400 -0.20499100 0.00000000 
390.28074 0.00000000 0.00000000 1.00000000 -178.47500 
28 'point symmetry operation' ?     ?     0.14266300  0.98977100  0.00000000 -23.66874 -0.98977100 0.14266300  0.00000000 
330.11510 0.00000000 0.00000000 1.00000000 -175.45000 
29 'point symmetry operation' ?     ?     0.47305800  0.88103100  0.00000000 -63.28286 -0.88103100 0.47305800  0.00000000 
251.63291 0.00000000 0.00000000 1.00000000 -172.42500 
30 'point symmetry operation' ?     ?     0.74622000  0.66569900  0.00000000 -73.61824 -0.66569900 0.74622000  0.00000000 
164.32934 0.00000000 0.00000000 1.00000000 -169.40000 
31 'point symmetry operation' ?     ?     0.92910000  0.36982800  0.00000000 -53.42444 -0.36982800 0.92910000  0.00000000 78.76683 
0.00000000 0.00000000 1.00000000 -166.37500 
32 'point symmetry operation' ?     ?     0.99957300  0.02921300  0.00000000 -5.14461  -0.02921300 0.99957300  0.00000000 5.29716 
0.00000000 0.00000000 1.00000000 -163.35000 
33 'point symmetry operation' ?     ?     0.94911300  -0.31493700 0.00000000 65.38010  0.31493700  0.94911300  0.00000000 
-47.19092 0.00000000 0.00000000 1.00000000 -160.32500 
34 'point symmetry operation' ?     ?     0.78382400  -0.62098400 0.00000000 149.61725 0.62098400  0.78382400  0.00000000 
-72.34714 0.00000000 0.00000000 1.00000000 -157.30000 
35 'point symmetry operation' ?     ?     0.52370300  -0.85190100 0.00000000 237.37541 0.85190100  0.52370300  0.00000000 
-67.12796 0.00000000 0.00000000 1.00000000 -154.27500 
36 'point symmetry operation' ?     ?     0.20022300  -0.97975000 0.00000000 318.03713 0.97975000  0.20022300  0.00000000 
-32.16484 0.00000000 0.00000000 1.00000000 -151.25000 
37 'point symmetry operation' ?     ?     -0.14748100 -0.98906500 0.00000000 381.84355 0.98906500  -0.14748100 0.00000000 28.31222 
0.00000000 0.00000000 1.00000000 -148.22500 
38 'point symmetry operation' ?     ?     -0.47734300 -0.87871700 0.00000000 421.07504 0.87871700  -0.47734300 0.00000000 
106.98638 0.00000000 0.00000000 1.00000000 -145.20000 
39 'point symmetry operation' ?     ?     -0.74945300 -0.66205800 0.00000000 430.98517 0.66205800  -0.74945300 0.00000000 
194.33924 0.00000000 0.00000000 1.00000000 -142.17500 
40 'point symmetry operation' ?     ?     -0.93089000 -0.36529900 0.00000000 410.37497 0.36529900  -0.93089000 0.00000000 
279.80241 0.00000000 0.00000000 1.00000000 -139.15000 
41 'point symmetry operation' ?     ?     -0.99970400 -0.02434500 0.00000000 361.73796 0.02434500  -0.99970400 0.00000000 
353.03610 0.00000000 0.00000000 1.00000000 -136.12500 
42 'point symmetry operation' ?     ?     -0.94756800 0.31955500  0.00000000 290.95850 -0.31955500 -0.94756800 0.00000000 
405.18014 0.00000000 0.00000000 1.00000000 -133.10000 
43 'point symmetry operation' ?     ?     -0.78079000 0.62479300  0.00000000 206.59984 -0.62479300 -0.78079000 0.00000000 
429.92587 0.00000000 0.00000000 1.00000000 -130.07500 
44 'point symmetry operation' ?     ?     -0.51954900 0.85444100  0.00000000 118.86815 -0.85444100 -0.51954900 0.00000000 
424.27943 0.00000000 0.00000000 1.00000000 -127.05000 
45 'point symmetry operation' ?     ?     -0.19545000 0.98071400  0.00000000 38.37763  -0.98071400 -0.19545000 0.00000000 
388.92394 0.00000000 0.00000000 1.00000000 -124.02500 
46 'point symmetry operation' ?     ?     0.15229600  0.98833500  0.00000000 -25.13354 -0.98833500 0.15229600  0.00000000 
328.13690 0.00000000 0.00000000 1.00000000 -121.00000 
47 'point symmetry operation' ?     ?     0.48161600  0.87638200  0.00000000 -63.98147 -0.87638200 0.48161600  0.00000000 
249.27264 0.00000000 0.00000000 1.00000000 -117.97500 
48 'point symmetry operation' ?     ?     0.75266800  0.65840100  0.00000000 -73.46612 -0.65840100 0.75266800  0.00000000 
161.87255 0.00000000 0.00000000 1.00000000 -114.95000 
49 'point symmetry operation' ?     ?     0.93265800  0.36076200  0.00000000 -52.44001 -0.36076200 0.93265800  0.00000000 76.51076 
0.00000000 0.00000000 1.00000000 -111.92500 
50 'point symmetry operation' ?     ?     0.99981000  0.01947700  0.00000000 -3.44696  -0.01947700 0.99981000  0.00000000 3.51477 
0.00000000 0.00000000 1.00000000 -108.90000 
51 'point symmetry operation' ?     ?     0.94600100  -0.32416500 0.00000000 67.58557  0.32416500  0.94600100  0.00000000 
-48.28400 0.00000000 0.00000000 1.00000000 -105.87500 
52 'point symmetry operation' ?     ?     0.77773900  -0.62858800 0.00000000 152.06372 0.62858800  0.77773900  0.00000000 
-72.61866 0.00000000 0.00000000 1.00000000 -102.85000 
53 'point symmetry operation' ?     ?     0.51538200  -0.85696000 0.00000000 239.76688 0.85696000  0.51538200  0.00000000 
-66.54507 0.00000000 0.00000000 1.00000000 -99.82500  
54 'point symmetry operation' ?     ?     0.19067200  -0.98165400 0.00000000 320.08428 0.98165400  0.19067200  0.00000000 
-30.79806 0.00000000 0.00000000 1.00000000 -96.80000  
55 'point symmetry operation' ?     ?     -0.15710700 -0.98758200 0.00000000 383.29870 0.98758200  -0.15710700 0.00000000 30.29753 
0.00000000 0.00000000 1.00000000 -93.77500  
56 'point symmetry operation' ?     ?     -0.48587800 -0.87402700 0.00000000 421.76214 0.87402700  -0.48587800 0.00000000 
109.35002 0.00000000 0.00000000 1.00000000 -90.75000  
57 'point symmetry operation' ?     ?     -0.75586500 -0.65472800 0.00000000 430.82109 0.65472800  -0.75586500 0.00000000 
196.79525 0.00000000 0.00000000 1.00000000 -87.72500  
58 'point symmetry operation' ?     ?     -0.93440400 -0.35621600 0.00000000 409.37956 0.35621600  -0.93440400 0.00000000 
282.05365 0.00000000 0.00000000 1.00000000 -84.70000  
59 'point symmetry operation' ?     ?     -0.99989300 -0.01460800 0.00000000 360.03165 0.01460800  -0.99989300 0.00000000 
354.81021 0.00000000 0.00000000 1.00000000 -81.67500  
60 'point symmetry operation' ?     ?     -0.94441100 0.32876800  0.00000000 288.74773 -0.32876800 -0.94441100 0.00000000 
406.26247 0.00000000 0.00000000 1.00000000 -78.65000  
61 'point symmetry operation' ?     ?     -0.77466900 0.63236700  0.00000000 204.15208 -0.63236700 -0.77466900 0.00000000 
430.18548 0.00000000 0.00000000 1.00000000 -75.62500  
62 'point symmetry operation' ?     ?     -0.51120300 0.85946000  0.00000000 116.47953 -0.85946000 -0.51120300 0.00000000 
423.68490 0.00000000 0.00000000 1.00000000 -72.60000  
63 'point symmetry operation' ?     ?     -0.18589000 0.98257100  0.00000000 36.33716  -0.98257100 -0.18589000 0.00000000 
387.54721 0.00000000 0.00000000 1.00000000 -69.57500  
64 'point symmetry operation' ?     ?     0.16191400  0.98680500  0.00000000 -26.57901 -0.98680500 0.16191400  0.00000000 
326.14453 0.00000000 0.00000000 1.00000000 -66.55000  
65 'point symmetry operation' ?     ?     0.49012800  0.87165000  0.00000000 -64.65705 -0.87165000 0.49012800  0.00000000 
246.90567 0.00000000 0.00000000 1.00000000 -63.52500  
66 'point symmetry operation' ?     ?     0.75904400  0.65103900  0.00000000 -73.29009 -0.65103900 0.75904400  0.00000000 
159.41737 0.00000000 0.00000000 1.00000000 -60.50000  
67 'point symmetry operation' ?     ?     0.93612700  0.35166200  0.00000000 -51.43365 -0.35166200 0.93612700  0.00000000 74.26439 
0.00000000 0.00000000 1.00000000 -57.47500  
68 'point symmetry operation' ?     ?     0.99995300  0.00973900  0.00000000 -1.73204  -0.00973900 0.99995300  0.00000000 1.74899 
0.00000000 0.00000000 1.00000000 -54.45000  
69 'point symmetry operation' ?     ?     0.94279900  -0.33336300 0.00000000 69.80158  0.33336300  0.94279900  0.00000000 
-49.35555 0.00000000 0.00000000 1.00000000 -51.42500  
70 'point symmetry operation' ?     ?     0.77158000  -0.63613200 0.00000000 154.51272 0.63613200  0.77158000  0.00000000 
-72.86634 0.00000000 0.00000000 1.00000000 -48.40000  
71 'point symmetry operation' ?     ?     0.50701200  -0.86193900 0.00000000 242.15257 0.86193900  0.50701200  0.00000000 
-65.93892 0.00000000 0.00000000 1.00000000 -45.37500  
72 'point symmetry operation' ?     ?     0.18110300  -0.98346400 0.00000000 322.11803 0.98346400  0.18110300  0.00000000 
-29.41141 0.00000000 0.00000000 1.00000000 -42.35000  
73 'point symmetry operation' ?     ?     -0.16671700 -0.98600500 0.00000000 384.73446 0.98600500  -0.16671700 0.00000000 32.29691 
0.00000000 0.00000000 1.00000000 -39.32500  
74 'point symmetry operation' ?     ?     -0.49436700 -0.86925300 0.00000000 422.42620 0.86925300  -0.49436700 0.00000000 
111.72025 0.00000000 0.00000000 1.00000000 -36.30000  
75 'point symmetry operation' ?     ?     -0.76220500 -0.64733500 0.00000000 430.63311 0.64733500  -0.76220500 0.00000000 
199.24955 0.00000000 0.00000000 1.00000000 -33.27500  
76 'point symmetry operation' ?     ?     -0.93782800 -0.34709900 0.00000000 408.36228 0.34709900  -0.93782800 0.00000000 
284.29509 0.00000000 0.00000000 1.00000000 -30.25000  
77 'point symmetry operation' ?     ?     -0.99998800 -0.00486900 0.00000000 358.30815 0.00486900  -0.99998800 0.00000000 
356.56761 0.00000000 0.00000000 1.00000000 -27.22500  
78 'point symmetry operation' ?     ?     -0.94116400 0.33795000  0.00000000 286.52652 -0.33795000 -0.94116400 0.00000000 
407.32322 0.00000000 0.00000000 1.00000000 -24.20000  
79 'point symmetry operation' ?     ?     -0.76847300 0.63988200  0.00000000 201.70191 -0.63988200 -0.76847300 0.00000000 
430.42123 0.00000000 0.00000000 1.00000000 -21.17500  
80 'point symmetry operation' ?     ?     -0.50280900 0.86439800  0.00000000 114.09683 -0.86439800 -0.50280900 0.00000000 
423.06713 0.00000000 0.00000000 1.00000000 -18.15000  
81 'point symmetry operation' ?     ?     -0.17631200 0.98433400  0.00000000 34.31019  -0.98433400 -0.17631200 0.00000000 
386.15067 0.00000000 0.00000000 1.00000000 -15.12500  
82 'point symmetry operation' ?     ?     0.17151600  0.98518100  0.00000000 -28.00501 -0.98518100 0.17151600  0.00000000 
324.13818 0.00000000 0.00000000 1.00000000 -12.10000  
83 'point symmetry operation' ?     ?     0.49859400  0.86683600  0.00000000 -65.30956 -0.86683600 0.49859400  0.00000000 
244.53224 0.00000000 0.00000000 1.00000000 -9.07500   
84 'point symmetry operation' ?     ?     0.76534800  0.64361600  0.00000000 -73.09015 -0.64361600 0.76534800  0.00000000 
156.96401 0.00000000 0.00000000 1.00000000 -6.05000   
85 'point symmetry operation' ?     ?     0.93950700  0.34252900  0.00000000 -50.40546 -0.34252900 0.93950700  0.00000000 72.02793 
0.00000000 0.00000000 1.00000000 -3.02500   
86 'identity operation'       1_555 x,y,z 1.00000000  0.00000000  0.00000000 0.00000   0.00000000  1.00000000  0.00000000 0.00000 
0.00000000 0.00000000 1.00000000 0.00000    
87 'point symmetry operation' ?     ?     0.93950700  -0.34252900 0.00000000 72.02793  0.34252900  0.93950700  0.00000000 
-50.40546 0.00000000 0.00000000 1.00000000 3.02500    
88 'point symmetry operation' ?     ?     0.76534800  -0.64361600 0.00000000 156.96401 0.64361600  0.76534800  0.00000000 
-73.09015 0.00000000 0.00000000 1.00000000 6.05000    
89 'point symmetry operation' ?     ?     0.49859400  -0.86683600 0.00000000 244.53224 0.86683600  0.49859400  0.00000000 
-65.30956 0.00000000 0.00000000 1.00000000 9.07500    
90 'point symmetry operation' ?     ?     0.17151600  -0.98518100 0.00000000 324.13818 0.98518100  0.17151600  0.00000000 
-28.00501 0.00000000 0.00000000 1.00000000 12.10000   
91 'point symmetry operation' ?     ?     -0.17631200 -0.98433400 0.00000000 386.15067 0.98433400  -0.17631200 0.00000000 34.31019 
0.00000000 0.00000000 1.00000000 15.12500   
92 'point symmetry operation' ?     ?     -0.50280900 -0.86439800 0.00000000 423.06713 0.86439800  -0.50280900 0.00000000 
114.09683 0.00000000 0.00000000 1.00000000 18.15000   
93 'point symmetry operation' ?     ?     -0.76847300 -0.63988200 0.00000000 430.42123 0.63988200  -0.76847300 0.00000000 
201.70191 0.00000000 0.00000000 1.00000000 21.17500   
94 'point symmetry operation' ?     ?     -0.94116400 -0.33795000 0.00000000 407.32322 0.33795000  -0.94116400 0.00000000 
286.52652 0.00000000 0.00000000 1.00000000 24.20000   
95 'point symmetry operation' ?     ?     -0.99998800 0.00486900  0.00000000 356.56761 -0.00486900 -0.99998800 0.00000000 
358.30815 0.00000000 0.00000000 1.00000000 27.22500   
96 'point symmetry operation' ?     ?     -0.93782800 0.34709900  0.00000000 284.29509 -0.34709900 -0.93782800 0.00000000 
408.36228 0.00000000 0.00000000 1.00000000 30.25000   
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 2   ? LYS A 42  ? SER A 2   LYS A 42  1 ? 41 
HELX_P HELX_P2  AA2 ASN A 44  ? MET A 106 ? ASN A 44  MET A 106 1 ? 63 
HELX_P HELX_P3  AA3 ASN A 107 ? THR A 140 ? ASN A 107 THR A 140 1 ? 34 
HELX_P HELX_P4  AA4 PRO A 145 ? GLY A 161 ? PRO A 145 GLY A 161 1 ? 17 
HELX_P HELX_P5  AA5 GLU A 187 ? VAL A 199 ? GLU A 187 VAL A 199 1 ? 13 
HELX_P HELX_P6  AA6 LYS B 7   ? ALA B 46  ? LYS B 7   ALA B 46  1 ? 40 
HELX_P HELX_P7  AA7 LYS B 48  ? ARG B 82  ? LYS B 48  ARG B 82  1 ? 35 
HELX_P HELX_P8  AA8 ARG B 82  ? MET B 89  ? ARG B 82  MET B 89  1 ? 8  
HELX_P HELX_P9  AA9 LEU B 96  ? GLN B 111 ? LEU B 96  GLN B 111 1 ? 16 
HELX_P HELX_P10 AB1 ALA B 115 ? TYR B 128 ? ALA B 115 TYR B 128 1 ? 14 
HELX_P HELX_P11 AB2 SER B 129 ? THR B 138 ? SER B 129 THR B 138 1 ? 10 
HELX_P HELX_P12 AB3 ASN B 145 ? LEU B 152 ? ASN B 145 LEU B 152 1 ? 8  
HELX_P HELX_P13 AB4 PRO B 158 ? TYR B 173 ? PRO B 158 TYR B 173 1 ? 16 
HELX_P HELX_P14 AB5 ASP B 180 ? ALA B 185 ? ASP B 180 ALA B 185 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8V2R 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    LYS 
_pdbx_validate_torsion.auth_asym_id    B 
_pdbx_validate_torsion.auth_seq_id     48 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -93.11 
_pdbx_validate_torsion.psi             57.58 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8V2R 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      OTHER 
# 
loop_
_em_3d_fitting_list.id 
_em_3d_fitting_list.3d_fitting_id 
_em_3d_fitting_list.pdb_entry_id 
_em_3d_fitting_list.pdb_chain_id 
_em_3d_fitting_list.pdb_chain_residue_range 
_em_3d_fitting_list.details 
_em_3d_fitting_list.chain_id 
_em_3d_fitting_list.chain_residue_range 
_em_3d_fitting_list.source_name 
_em_3d_fitting_list.type 
_em_3d_fitting_list.accession_code 
_em_3d_fitting_list.initial_refinement_model_id 
1 1 6TZ4 A ? 'Isolated CHMP1B monomer for each biological unit used as initial model' A ? PDB 'experimental model' 6TZ4 1 
2 1 3FRR B ? 'Isolated IST1 monomer for each biological unit used as initial model'   B ? PDB 'experimental model' 3FRR 2 
# 
_em_3d_reconstruction.entry_id                    8V2R 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'FOURIER SPACE' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.01 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               259006 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          10 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               HELICAL 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 RECOMBINANT COMPLEX 'CHMP1B/IST1 copolymer bound to a 60-mer oligonucleotide of ssDNA' 
;Complex assembly formed my mixing protein and oligonucleotide at a 1:20 molar ratio (protein to base) by dialysis into physiological buffer conditions
;
? ? '1, 2' 
2 1 RECOMBINANT COMPLEX 'Charged multivesicular body protein 1B (CHMP1B)'                  
'CHMP1B component of the nucleic acid templated helical assembly' ? ? 1      
3 1 RECOMBINANT COMPLEX IST1                                                               
'IST1 component of the nucleic acid templated assembly' ? ? 2      
# 
_em_imaging.entry_id                        8V2R 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS GLACIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           OTHER 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            200 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1800 
_em_imaging.calibrated_defocus_min          100 
_em_imaging.calibrated_defocus_max          4000 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            50.0 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R0.6/1' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8V2R 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   292.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8V2R 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.aggregation_state       FILAMENT 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 171 ? A GLY 171 
2   1 Y 1 A GLN 172 ? A GLN 172 
3   1 Y 1 A THR 173 ? A THR 173 
4   1 Y 1 A GLY 174 ? A GLY 174 
5   1 Y 1 A SER 175 ? A SER 175 
6   1 Y 1 A VAL 176 ? A VAL 176 
7   1 Y 1 A GLY 177 ? A GLY 177 
8   1 Y 1 A THR 178 ? A THR 178 
9   1 Y 1 A SER 179 ? A SER 179 
10  1 Y 1 A VAL 180 ? A VAL 180 
11  1 Y 1 A ALA 181 ? A ALA 181 
12  1 Y 1 A SER 182 ? A SER 182 
13  1 Y 1 A ALA 183 ? A ALA 183 
14  1 Y 1 A GLU 184 ? A GLU 184 
15  1 Y 1 A GLN 185 ? A GLN 185 
16  1 Y 1 B MET 1   ? B MET 1   
17  1 Y 1 B LEU 2   ? B LEU 2   
18  1 Y 1 B GLY 3   ? B GLY 3   
19  1 Y 1 B PRO 188 ? B PRO 188 
20  1 Y 1 B PRO 189 ? B PRO 189 
21  1 Y 1 B GLY 190 ? B GLY 190 
22  1 Y 1 B VAL 191 ? B VAL 191 
23  1 Y 1 B GLU 192 ? B GLU 192 
24  1 Y 1 B THR 193 ? B THR 193 
25  1 Y 1 B ASP 194 ? B ASP 194 
26  1 Y 1 B LEU 195 ? B LEU 195 
27  1 Y 1 B ILE 196 ? B ILE 196 
28  1 Y 1 B ASP 197 ? B ASP 197 
29  1 Y 1 B VAL 198 ? B VAL 198 
30  1 Y 1 B GLY 199 ? B GLY 199 
31  1 Y 1 B PHE 200 ? B PHE 200 
32  1 Y 1 B THR 201 ? B THR 201 
33  1 Y 1 B ASP 202 ? B ASP 202 
34  1 Y 1 B ASP 203 ? B ASP 203 
35  1 Y 1 B VAL 204 ? B VAL 204 
36  1 Y 1 B LYS 205 ? B LYS 205 
37  1 Y 1 B LYS 206 ? B LYS 206 
38  1 Y 1 B GLY 207 ? B GLY 207 
39  1 Y 1 B GLY 208 ? B GLY 208 
40  1 Y 1 B PRO 209 ? B PRO 209 
41  1 Y 1 B GLY 210 ? B GLY 210 
42  1 Y 1 B ARG 211 ? B ARG 211 
43  1 Y 1 B GLY 212 ? B GLY 212 
44  1 Y 1 B GLY 213 ? B GLY 213 
45  1 Y 1 B SER 214 ? B SER 214 
46  1 Y 1 B GLY 215 ? B GLY 215 
47  1 Y 1 B GLY 216 ? B GLY 216 
48  1 Y 1 B PHE 217 ? B PHE 217 
49  1 Y 1 B THR 218 ? B THR 218 
50  1 Y 1 B ALA 219 ? B ALA 219 
51  1 Y 1 B PRO 220 ? B PRO 220 
52  1 Y 1 B VAL 221 ? B VAL 221 
53  1 Y 1 B GLY 222 ? B GLY 222 
54  1 Y 1 B GLY 223 ? B GLY 223 
55  1 Y 1 B PRO 224 ? B PRO 224 
56  1 Y 1 B ASP 225 ? B ASP 225 
57  1 Y 1 B GLY 226 ? B GLY 226 
58  1 Y 1 B THR 227 ? B THR 227 
59  1 Y 1 B VAL 228 ? B VAL 228 
60  1 Y 1 B PRO 229 ? B PRO 229 
61  1 Y 1 B MET 230 ? B MET 230 
62  1 Y 1 B PRO 231 ? B PRO 231 
63  1 Y 1 B MET 232 ? B MET 232 
64  1 Y 1 B PRO 233 ? B PRO 233 
65  1 Y 1 B MET 234 ? B MET 234 
66  1 Y 1 B PRO 235 ? B PRO 235 
67  1 Y 1 B MET 236 ? B MET 236 
68  1 Y 1 B PRO 237 ? B PRO 237 
69  1 Y 1 B SER 238 ? B SER 238 
70  1 Y 1 B ALA 239 ? B ALA 239 
71  1 Y 1 B ASN 240 ? B ASN 240 
72  1 Y 1 B THR 241 ? B THR 241 
73  1 Y 1 B PRO 242 ? B PRO 242 
74  1 Y 1 B PHE 243 ? B PHE 243 
75  1 Y 1 B SER 244 ? B SER 244 
76  1 Y 1 B TYR 245 ? B TYR 245 
77  1 Y 1 B PRO 246 ? B PRO 246 
78  1 Y 1 B LEU 247 ? B LEU 247 
79  1 Y 1 B PRO 248 ? B PRO 248 
80  1 Y 1 B LYS 249 ? B LYS 249 
81  1 Y 1 B GLY 250 ? B GLY 250 
82  1 Y 1 B PRO 251 ? B PRO 251 
83  1 Y 1 B SER 252 ? B SER 252 
84  1 Y 1 B ASP 253 ? B ASP 253 
85  1 Y 1 B PHE 254 ? B PHE 254 
86  1 Y 1 B ASN 255 ? B ASN 255 
87  1 Y 1 B GLY 256 ? B GLY 256 
88  1 Y 1 B LEU 257 ? B LEU 257 
89  1 Y 1 B PRO 258 ? B PRO 258 
90  1 Y 1 B MET 259 ? B MET 259 
91  1 Y 1 B GLY 260 ? B GLY 260 
92  1 Y 1 B THR 261 ? B THR 261 
93  1 Y 1 B TYR 262 ? B TYR 262 
94  1 Y 1 B GLN 263 ? B GLN 263 
95  1 Y 1 B ALA 264 ? B ALA 264 
96  1 Y 1 B PHE 265 ? B PHE 265 
97  1 Y 1 B PRO 266 ? B PRO 266 
98  1 Y 1 B ASN 267 ? B ASN 267 
99  1 Y 1 B ILE 268 ? B ILE 268 
100 1 Y 1 B HIS 269 ? B HIS 269 
101 1 Y 1 B PRO 270 ? B PRO 270 
102 1 Y 1 B PRO 271 ? B PRO 271 
103 1 Y 1 B GLN 272 ? B GLN 272 
104 1 Y 1 B ILE 273 ? B ILE 273 
105 1 Y 1 B PRO 274 ? B PRO 274 
106 1 Y 1 B ALA 275 ? B ALA 275 
107 1 Y 1 B THR 276 ? B THR 276 
108 1 Y 1 B PRO 277 ? B PRO 277 
109 1 Y 1 B PRO 278 ? B PRO 278 
110 1 Y 1 B SER 279 ? B SER 279 
111 1 Y 1 B TYR 280 ? B TYR 280 
112 1 Y 1 B GLU 281 ? B GLU 281 
113 1 Y 1 B SER 282 ? B SER 282 
114 1 Y 1 B VAL 283 ? B VAL 283 
115 1 Y 1 B ASP 284 ? B ASP 284 
116 1 Y 1 B ASP 285 ? B ASP 285 
117 1 Y 1 B ILE 286 ? B ILE 286 
118 1 Y 1 B ASN 287 ? B ASN 287 
119 1 Y 1 B ALA 288 ? B ALA 288 
120 1 Y 1 B ASP 289 ? B ASP 289 
121 1 Y 1 B LYS 290 ? B LYS 290 
122 1 Y 1 B ASN 291 ? B ASN 291 
123 1 Y 1 B ILE 292 ? B ILE 292 
124 1 Y 1 B SER 293 ? B SER 293 
125 1 Y 1 B SER 294 ? B SER 294 
126 1 Y 1 B ALA 295 ? B ALA 295 
127 1 Y 1 B GLN 296 ? B GLN 296 
128 1 Y 1 B ILE 297 ? B ILE 297 
129 1 Y 1 B VAL 298 ? B VAL 298 
130 1 Y 1 B GLY 299 ? B GLY 299 
131 1 Y 1 B PRO 300 ? B PRO 300 
132 1 Y 1 B GLY 301 ? B GLY 301 
133 1 Y 1 B PRO 302 ? B PRO 302 
134 1 Y 1 B LYS 303 ? B LYS 303 
135 1 Y 1 B PRO 304 ? B PRO 304 
136 1 Y 1 B GLU 305 ? B GLU 305 
137 1 Y 1 B ALA 306 ? B ALA 306 
138 1 Y 1 B SER 307 ? B SER 307 
139 1 Y 1 B ALA 308 ? B ALA 308 
140 1 Y 1 B LYS 309 ? B LYS 309 
141 1 Y 1 B LEU 310 ? B LEU 310 
142 1 Y 1 B PRO 311 ? B PRO 311 
143 1 Y 1 B SER 312 ? B SER 312 
144 1 Y 1 B ARG 313 ? B ARG 313 
145 1 Y 1 B PRO 314 ? B PRO 314 
146 1 Y 1 B ALA 315 ? B ALA 315 
147 1 Y 1 B ASP 316 ? B ASP 316 
148 1 Y 1 B ASN 317 ? B ASN 317 
149 1 Y 1 B TYR 318 ? B TYR 318 
150 1 Y 1 B ASP 319 ? B ASP 319 
151 1 Y 1 B ASN 320 ? B ASN 320 
152 1 Y 1 B PHE 321 ? B PHE 321 
153 1 Y 1 B VAL 322 ? B VAL 322 
154 1 Y 1 B LEU 323 ? B LEU 323 
155 1 Y 1 B PRO 324 ? B PRO 324 
156 1 Y 1 B GLU 325 ? B GLU 325 
157 1 Y 1 B LEU 326 ? B LEU 326 
158 1 Y 1 B PRO 327 ? B PRO 327 
159 1 Y 1 B SER 328 ? B SER 328 
160 1 Y 1 B VAL 329 ? B VAL 329 
161 1 Y 1 B PRO 330 ? B PRO 330 
162 1 Y 1 B ASP 331 ? B ASP 331 
163 1 Y 1 B THR 332 ? B THR 332 
164 1 Y 1 B LEU 333 ? B LEU 333 
165 1 Y 1 B PRO 334 ? B PRO 334 
166 1 Y 1 B THR 335 ? B THR 335 
167 1 Y 1 B ALA 336 ? B ALA 336 
168 1 Y 1 B SER 337 ? B SER 337 
169 1 Y 1 B ALA 338 ? B ALA 338 
170 1 Y 1 B GLY 339 ? B GLY 339 
171 1 Y 1 B ALA 340 ? B ALA 340 
172 1 Y 1 B SER 341 ? B SER 341 
173 1 Y 1 B THR 342 ? B THR 342 
174 1 Y 1 B SER 343 ? B SER 343 
175 1 Y 1 B ALA 344 ? B ALA 344 
176 1 Y 1 B SER 345 ? B SER 345 
177 1 Y 1 B GLU 346 ? B GLU 346 
178 1 Y 1 B ASP 347 ? B ASP 347 
179 1 Y 1 B ILE 348 ? B ILE 348 
180 1 Y 1 B ASP 349 ? B ASP 349 
181 1 Y 1 B PHE 350 ? B PHE 350 
182 1 Y 1 B ASP 351 ? B ASP 351 
183 1 Y 1 B ASP 352 ? B ASP 352 
184 1 Y 1 B LEU 353 ? B LEU 353 
185 1 Y 1 B SER 354 ? B SER 354 
186 1 Y 1 B ARG 355 ? B ARG 355 
187 1 Y 1 B ARG 356 ? B ARG 356 
188 1 Y 1 B PHE 357 ? B PHE 357 
189 1 Y 1 B GLU 358 ? B GLU 358 
190 1 Y 1 B GLU 359 ? B GLU 359 
191 1 Y 1 B LEU 360 ? B LEU 360 
192 1 Y 1 B LYS 361 ? B LYS 361 
193 1 Y 1 B LYS 362 ? B LYS 362 
194 1 Y 1 B LYS 363 ? B LYS 363 
195 1 Y 1 B THR 364 ? B THR 364 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-11-23 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8V2R 
_em_admin.last_update        2024-11-27 
_em_admin.map_release_date   2024-11-27 
_em_admin.title              'CryoEM of ssDNA bound CHMP1B/IST1 copolymer assembly' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 50  mM Tris-HCl 1 'Tris Hydrochloride' 
1 125 mM NaCl     2 'Sodium Chloride'    
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
loop_
_em_entity_assembly_molwt.entity_assembly_id 
_em_entity_assembly_molwt.experimental_flag 
_em_entity_assembly_molwt.id 
_em_entity_assembly_molwt.units 
_em_entity_assembly_molwt.value 
1 NO  1 ?           ?        
1 YES 2 MEGADALTONS 0.220762 
1 YES 3 MEGADALTONS 0.397494 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 1 2 9606 'Homo sapiens' ? ? ? ? ? 
? ? 2 3 9606 'Homo sapiens' ? ? ? ? ? 
? ? 3 4 9606 'Homo sapiens' ? ? ? ? ? 
# 
loop_
_em_entity_assembly_recombinant.cell 
_em_entity_assembly_recombinant.entity_assembly_id 
_em_entity_assembly_recombinant.id 
_em_entity_assembly_recombinant.ncbi_tax_id 
_em_entity_assembly_recombinant.organism 
_em_entity_assembly_recombinant.plasmid 
_em_entity_assembly_recombinant.strain 
? 1 2 469008 'Escherichia coli BL21(DE3)' pET28 ? 
? 2 3 469008 'Escherichia coli BL21(DE3)' pET28 ? 
? 3 4 469008 'Escherichia coli BL21(DE3)' pET28 ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.details                        ? 
_em_helical_entity.axial_symmetry                 C1 
_em_helical_entity.angular_rotation_per_subunit   20.047 
_em_helical_entity.axial_rise_per_subunit         3.028 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    10 
_em_imaging_optics.energyfilter_name          'TFS Selectris' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   591872 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? cryoSPARC 4.2.1  
'IMAGE ACQUISITION'        ? 2  ? ? 1 EPU       3.4    
MASKING                    ? 3  ? ? ? ?         ?      
'CTF CORRECTION'           ? 4  1 ? ? cryoSPARC 4.2.1  
'LAYERLINE INDEXING'       ? 5  ? ? ? ?         ?      
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?         ?      
'MODEL FITTING'            ? 7  ? 1 ? ISOLDE    1.6.0  
OTHER                      ? 8  ? ? ? ?         ?      
'INITIAL EULER ASSIGNMENT' ? 9  1 ? ? cryoSPARC 4.2.1  
'FINAL EULER ASSIGNMENT'   ? 10 1 ? ? cryoSPARC V4.2.1 
CLASSIFICATION             ? 11 1 ? ? cryoSPARC 4.2.1  
RECONSTRUCTION             ? 12 1 ? ? cryoSPARC 4.2.1  
'MODEL REFINEMENT'         ? 13 ? 1 ? ISOLDE    1.6.0  
# 
_em_specimen.concentration           ? 
_em_specimen.details                 'Sample is at 16 micromolar protein concentration.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/Office of the Director'                                     'United States' S10OD020054     1 
'National Institutes of Health/Office of the Director'                                     'United States' 1S10OD021741    2 
'National Institutes of Health/Office of the Director'                                     'United States' 1S10OD021596-01 3 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 1DP2GM110772-01 4 
'Howard Hughes Medical Institute (HHMI)'                                                   'United States' ?               5 
'Chan Zuckerberg Initiative'                                                               'United States' ?               6 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
1 'experimental model' PDB 6TZ4 
2 'experimental model' PDB 3FRR 
# 
_atom_sites.entry_id                    8V2R 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . MET A 1 1   ? 192.154 117.716 271.573 1.00 109.37 ? 1   MET A N   1 
ATOM 2    C CA  . MET A 1 1   ? 191.721 116.500 272.319 1.00 106.30 ? 1   MET A CA  1 
ATOM 3    C C   . MET A 1 1   ? 191.844 115.276 271.410 1.00 97.75  ? 1   MET A C   1 
ATOM 4    O O   . MET A 1 1   ? 191.252 115.238 270.330 1.00 91.40  ? 1   MET A O   1 
ATOM 5    C CB  . MET A 1 1   ? 190.278 116.656 272.819 1.00 109.21 ? 1   MET A CB  1 
ATOM 6    C CG  . MET A 1 1   ? 189.784 115.509 273.685 1.00 112.42 ? 1   MET A CG  1 
ATOM 7    S SD  . MET A 1 1   ? 188.081 115.733 274.252 1.00 118.88 ? 1   MET A SD  1 
ATOM 8    C CE  . MET A 1 1   ? 188.279 116.821 275.674 1.00 119.47 ? 1   MET A CE  1 
ATOM 9    N N   . SER A 1 2   ? 192.621 114.286 271.881 1.00 95.17  ? 2   SER A N   1 
ATOM 10   C CA  . SER A 1 2   ? 192.869 113.044 271.162 1.00 93.45  ? 2   SER A CA  1 
ATOM 11   C C   . SER A 1 2   ? 191.569 112.286 270.932 1.00 91.60  ? 2   SER A C   1 
ATOM 12   O O   . SER A 1 2   ? 190.597 112.485 271.654 1.00 99.30  ? 2   SER A O   1 
ATOM 13   C CB  . SER A 1 2   ? 193.833 112.166 271.912 1.00 94.08  ? 2   SER A CB  1 
ATOM 14   O OG  . SER A 1 2   ? 193.857 110.855 271.349 1.00 94.22  ? 2   SER A OG  1 
ATOM 15   N N   . ASN A 1 3   ? 191.581 111.374 269.966 1.00 87.67  ? 3   ASN A N   1 
ATOM 16   C CA  . ASN A 1 3   ? 190.391 110.624 269.608 1.00 84.19  ? 3   ASN A CA  1 
ATOM 17   C C   . ASN A 1 3   ? 189.974 109.676 270.735 1.00 78.42  ? 3   ASN A C   1 
ATOM 18   O O   . ASN A 1 3   ? 188.787 109.430 270.897 1.00 80.81  ? 3   ASN A O   1 
ATOM 19   C CB  . ASN A 1 3   ? 190.642 109.893 268.299 1.00 93.23  ? 3   ASN A CB  1 
ATOM 20   C CG  . ASN A 1 3   ? 189.379 109.624 267.521 1.00 99.86  ? 3   ASN A CG  1 
ATOM 21   O OD1 . ASN A 1 3   ? 188.616 110.563 267.222 1.00 102.67 ? 3   ASN A OD1 1 
ATOM 22   N ND2 . ASN A 1 3   ? 189.163 108.366 267.143 1.00 105.10 ? 3   ASN A ND2 1 
ATOM 23   N N   . MET A 1 4   ? 190.934 109.130 271.495 1.00 75.83  ? 4   MET A N   1 
ATOM 24   C CA  . MET A 1 4   ? 190.631 108.347 272.684 1.00 68.96  ? 4   MET A CA  1 
ATOM 25   C C   . MET A 1 4   ? 190.179 109.247 273.819 1.00 67.35  ? 4   MET A C   1 
ATOM 26   O O   . MET A 1 4   ? 189.393 108.820 274.642 1.00 77.34  ? 4   MET A O   1 
ATOM 27   C CB  . MET A 1 4   ? 191.839 107.591 273.230 1.00 68.81  ? 4   MET A CB  1 
ATOM 28   C CG  . MET A 1 4   ? 192.170 106.356 272.473 1.00 73.43  ? 4   MET A CG  1 
ATOM 29   S SD  . MET A 1 4   ? 191.315 104.922 273.132 1.00 75.03  ? 4   MET A SD  1 
ATOM 30   C CE  . MET A 1 4   ? 192.458 104.504 274.450 1.00 74.19  ? 4   MET A CE  1 
ATOM 31   N N   . GLU A 1 5   ? 190.695 110.463 273.913 1.00 69.73  ? 5   GLU A N   1 
ATOM 32   C CA  . GLU A 1 5   ? 190.285 111.336 274.993 1.00 76.10  ? 5   GLU A CA  1 
ATOM 33   C C   . GLU A 1 5   ? 188.837 111.776 274.807 1.00 73.80  ? 5   GLU A C   1 
ATOM 34   O O   . GLU A 1 5   ? 188.148 112.069 275.780 1.00 75.80  ? 5   GLU A O   1 
ATOM 35   C CB  . GLU A 1 5   ? 191.179 112.565 275.077 1.00 85.52  ? 5   GLU A CB  1 
ATOM 36   C CG  . GLU A 1 5   ? 192.579 112.237 275.588 1.00 98.15  ? 5   GLU A CG  1 
ATOM 37   C CD  . GLU A 1 5   ? 193.506 113.450 275.671 1.00 110.73 ? 5   GLU A CD  1 
ATOM 38   O OE1 . GLU A 1 5   ? 193.732 114.115 274.614 1.00 114.04 ? 5   GLU A OE1 1 
ATOM 39   O OE2 . GLU A 1 5   ? 194.010 113.737 276.796 1.00 112.95 ? 5   GLU A OE2 1 
ATOM 40   N N   . LYS A 1 6   ? 188.395 111.859 273.557 1.00 74.02  ? 6   LYS A N   1 
ATOM 41   C CA  . LYS A 1 6   ? 187.007 112.135 273.259 1.00 74.33  ? 6   LYS A CA  1 
ATOM 42   C C   . LYS A 1 6   ? 186.159 110.961 273.735 1.00 70.61  ? 6   LYS A C   1 
ATOM 43   O O   . LYS A 1 6   ? 185.132 111.168 274.361 1.00 78.03  ? 6   LYS A O   1 
ATOM 44   C CB  . LYS A 1 6   ? 186.860 112.408 271.763 1.00 84.53  ? 6   LYS A CB  1 
ATOM 45   C CG  . LYS A 1 6   ? 185.435 112.531 271.248 1.00 99.02  ? 6   LYS A CG  1 
ATOM 46   C CD  . LYS A 1 6   ? 185.297 112.289 269.740 1.00 108.45 ? 6   LYS A CD  1 
ATOM 47   C CE  . LYS A 1 6   ? 183.864 112.145 269.245 1.00 111.61 ? 6   LYS A CE  1 
ATOM 48   N NZ  . LYS A 1 6   ? 183.806 111.797 267.817 1.00 114.36 ? 6   LYS A NZ  1 
ATOM 49   N N   . HIS A 1 7   ? 186.574 109.730 273.454 1.00 66.77  ? 7   HIS A N   1 
ATOM 50   C CA  . HIS A 1 7   ? 185.846 108.578 273.950 1.00 63.93  ? 7   HIS A CA  1 
ATOM 51   C C   . HIS A 1 7   ? 185.886 108.514 275.472 1.00 59.07  ? 7   HIS A C   1 
ATOM 52   O O   . HIS A 1 7   ? 184.903 108.149 276.089 1.00 68.35  ? 7   HIS A O   1 
ATOM 53   C CB  . HIS A 1 7   ? 186.386 107.286 273.339 1.00 66.77  ? 7   HIS A CB  1 
ATOM 54   C CG  . HIS A 1 7   ? 186.196 107.224 271.873 1.00 70.68  ? 7   HIS A CG  1 
ATOM 55   N ND1 . HIS A 1 7   ? 185.141 107.820 271.207 1.00 74.50  ? 7   HIS A ND1 1 
ATOM 56   C CD2 . HIS A 1 7   ? 186.928 106.601 270.955 1.00 74.52  ? 7   HIS A CD2 1 
ATOM 57   C CE1 . HIS A 1 7   ? 185.252 107.558 269.915 1.00 78.07  ? 7   HIS A CE1 1 
ATOM 58   N NE2 . HIS A 1 7   ? 186.334 106.825 269.738 1.00 78.85  ? 7   HIS A NE2 1 
ATOM 59   N N   . LEU A 1 8   ? 187.013 108.823 276.090 1.00 58.29  ? 8   LEU A N   1 
ATOM 60   C CA  . LEU A 1 8   ? 187.102 108.751 277.534 1.00 60.30  ? 8   LEU A CA  1 
ATOM 61   C C   . LEU A 1 8   ? 186.118 109.728 278.153 1.00 64.53  ? 8   LEU A C   1 
ATOM 62   O O   . LEU A 1 8   ? 185.470 109.421 279.146 1.00 72.19  ? 8   LEU A O   1 
ATOM 63   C CB  . LEU A 1 8   ? 188.514 109.075 277.994 1.00 59.99  ? 8   LEU A CB  1 
ATOM 64   C CG  . LEU A 1 8   ? 188.738 109.117 279.505 1.00 60.16  ? 8   LEU A CG  1 
ATOM 65   C CD1 . LEU A 1 8   ? 188.456 107.803 280.173 1.00 61.86  ? 8   LEU A CD1 1 
ATOM 66   C CD2 . LEU A 1 8   ? 190.160 109.509 279.802 1.00 67.57  ? 8   LEU A CD2 1 
ATOM 67   N N   . PHE A 1 9   ? 186.041 110.924 277.587 1.00 68.15  ? 9   PHE A N   1 
ATOM 68   C CA  . PHE A 1 9   ? 185.151 111.940 278.106 1.00 71.29  ? 9   PHE A CA  1 
ATOM 69   C C   . PHE A 1 9   ? 183.698 111.493 277.980 1.00 69.37  ? 9   PHE A C   1 
ATOM 70   O O   . PHE A 1 9   ? 182.927 111.678 278.913 1.00 77.77  ? 9   PHE A O   1 
ATOM 71   C CB  . PHE A 1 9   ? 185.443 113.228 277.347 1.00 75.73  ? 9   PHE A CB  1 
ATOM 72   C CG  . PHE A 1 9   ? 184.511 114.355 277.744 1.00 82.47  ? 9   PHE A CG  1 
ATOM 73   C CD1 . PHE A 1 9   ? 184.777 115.133 278.863 1.00 88.25  ? 9   PHE A CD1 1 
ATOM 74   C CD2 . PHE A 1 9   ? 183.374 114.622 276.996 1.00 85.13  ? 9   PHE A CD2 1 
ATOM 75   C CE1 . PHE A 1 9   ? 183.929 116.168 279.211 1.00 93.33  ? 9   PHE A CE1 1 
ATOM 76   C CE2 . PHE A 1 9   ? 182.532 115.660 277.349 1.00 89.30  ? 9   PHE A CE2 1 
ATOM 77   C CZ  . PHE A 1 9   ? 182.813 116.433 278.449 1.00 92.69  ? 9   PHE A CZ  1 
ATOM 78   N N   . ASN A 1 10  ? 183.331 110.912 276.840 1.00 61.62  ? 10  ASN A N   1 
ATOM 79   C CA  . ASN A 1 10  ? 181.990 110.407 276.636 1.00 58.78  ? 10  ASN A CA  1 
ATOM 80   C C   . ASN A 1 10  ? 181.649 109.274 277.602 1.00 56.78  ? 10  ASN A C   1 
ATOM 81   O O   . ASN A 1 10  ? 180.524 109.202 278.065 1.00 65.12  ? 10  ASN A O   1 
ATOM 82   C CB  . ASN A 1 10  ? 181.792 109.945 275.201 1.00 63.75  ? 10  ASN A CB  1 
ATOM 83   C CG  . ASN A 1 10  ? 181.769 111.095 274.227 1.00 64.48  ? 10  ASN A CG  1 
ATOM 84   O OD1 . ASN A 1 10  ? 181.766 112.259 274.645 1.00 71.07  ? 10  ASN A OD1 1 
ATOM 85   N ND2 . ASN A 1 10  ? 181.761 110.801 272.933 1.00 65.01  ? 10  ASN A ND2 1 
ATOM 86   N N   . LEU A 1 11  ? 182.579 108.383 277.912 1.00 55.67  ? 11  LEU A N   1 
ATOM 87   C CA  . LEU A 1 11  ? 182.278 107.309 278.839 1.00 57.04  ? 11  LEU A CA  1 
ATOM 88   C C   . LEU A 1 11  ? 182.144 107.861 280.247 1.00 61.71  ? 11  LEU A C   1 
ATOM 89   O O   . LEU A 1 11  ? 181.283 107.407 280.981 1.00 70.98  ? 11  LEU A O   1 
ATOM 90   C CB  . LEU A 1 11  ? 183.322 106.199 278.800 1.00 58.83  ? 11  LEU A CB  1 
ATOM 91   C CG  . LEU A 1 11  ? 183.334 105.363 277.518 1.00 59.23  ? 11  LEU A CG  1 
ATOM 92   C CD1 . LEU A 1 11  ? 184.675 104.723 277.317 1.00 65.47  ? 11  LEU A CD1 1 
ATOM 93   C CD2 . LEU A 1 11  ? 182.263 104.313 277.528 1.00 58.74  ? 11  LEU A CD2 1 
ATOM 94   N N   . LYS A 1 12  ? 182.989 108.809 280.644 1.00 65.19  ? 12  LYS A N   1 
ATOM 95   C CA  . LYS A 1 12  ? 182.909 109.320 281.997 1.00 68.46  ? 12  LYS A CA  1 
ATOM 96   C C   . LYS A 1 12  ? 181.574 110.023 282.187 1.00 68.77  ? 12  LYS A C   1 
ATOM 97   O O   . LYS A 1 12  ? 180.986 109.934 283.257 1.00 74.03  ? 12  LYS A O   1 
ATOM 98   C CB  . LYS A 1 12  ? 184.041 110.292 282.315 1.00 73.54  ? 12  LYS A CB  1 
ATOM 99   C CG  . LYS A 1 12  ? 185.368 109.682 282.707 1.00 76.88  ? 12  LYS A CG  1 
ATOM 100  C CD  . LYS A 1 12  ? 186.362 110.793 283.026 1.00 81.28  ? 12  LYS A CD  1 
ATOM 101  C CE  . LYS A 1 12  ? 187.754 110.332 283.301 1.00 88.97  ? 12  LYS A CE  1 
ATOM 102  N NZ  . LYS A 1 12  ? 187.926 109.706 284.618 1.00 93.36  ? 12  LYS A NZ  1 
ATOM 103  N N   . PHE A 1 13  ? 181.121 110.714 281.141 1.00 69.51  ? 13  PHE A N   1 
ATOM 104  C CA  . PHE A 1 13  ? 179.866 111.438 281.176 1.00 74.75  ? 13  PHE A CA  1 
ATOM 105  C C   . PHE A 1 13  ? 178.705 110.464 281.291 1.00 71.85  ? 13  PHE A C   1 
ATOM 106  O O   . PHE A 1 13  ? 177.785 110.699 282.065 1.00 78.24  ? 13  PHE A O   1 
ATOM 107  C CB  . PHE A 1 13  ? 179.694 112.288 279.922 1.00 79.22  ? 13  PHE A CB  1 
ATOM 108  C CG  . PHE A 1 13  ? 178.396 113.073 279.852 1.00 88.59  ? 13  PHE A CG  1 
ATOM 109  C CD1 . PHE A 1 13  ? 178.254 114.284 280.519 1.00 93.28  ? 13  PHE A CD1 1 
ATOM 110  C CD2 . PHE A 1 13  ? 177.335 112.610 279.084 1.00 97.89  ? 13  PHE A CD2 1 
ATOM 111  C CE1 . PHE A 1 13  ? 177.072 114.999 280.430 1.00 98.88  ? 13  PHE A CE1 1 
ATOM 112  C CE2 . PHE A 1 13  ? 176.155 113.339 278.986 1.00 99.48  ? 13  PHE A CE2 1 
ATOM 113  C CZ  . PHE A 1 13  ? 176.025 114.525 279.664 1.00 100.12 ? 13  PHE A CZ  1 
ATOM 114  N N   . ALA A 1 14  ? 178.748 109.390 280.510 1.00 68.98  ? 14  ALA A N   1 
ATOM 115  C CA  . ALA A 1 14  ? 177.690 108.397 280.528 1.00 68.29  ? 14  ALA A CA  1 
ATOM 116  C C   . ALA A 1 14  ? 177.613 107.687 281.875 1.00 65.64  ? 14  ALA A C   1 
ATOM 117  O O   . ALA A 1 14  ? 176.542 107.228 282.267 1.00 72.18  ? 14  ALA A O   1 
ATOM 118  C CB  . ALA A 1 14  ? 177.894 107.397 279.422 1.00 66.16  ? 14  ALA A CB  1 
ATOM 119  N N   . ALA A 1 15  ? 178.729 107.559 282.572 1.00 65.36  ? 15  ALA A N   1 
ATOM 120  C CA  . ALA A 1 15  ? 178.684 106.900 283.861 1.00 70.94  ? 15  ALA A CA  1 
ATOM 121  C C   . ALA A 1 15  ? 177.959 107.788 284.859 1.00 75.99  ? 15  ALA A C   1 
ATOM 122  O O   . ALA A 1 15  ? 177.279 107.276 285.746 1.00 77.68  ? 15  ALA A O   1 
ATOM 123  C CB  . ALA A 1 15  ? 180.072 106.575 284.344 1.00 75.62  ? 15  ALA A CB  1 
ATOM 124  N N   . LYS A 1 16  ? 178.134 109.107 284.722 1.00 80.27  ? 16  LYS A N   1 
ATOM 125  C CA  . LYS A 1 16  ? 177.529 110.048 285.649 1.00 85.03  ? 16  LYS A CA  1 
ATOM 126  C C   . LYS A 1 16  ? 176.047 110.155 285.341 1.00 82.09  ? 16  LYS A C   1 
ATOM 127  O O   . LYS A 1 16  ? 175.226 110.187 286.250 1.00 88.34  ? 16  LYS A O   1 
ATOM 128  C CB  . LYS A 1 16  ? 178.175 111.436 285.606 1.00 90.96  ? 16  LYS A CB  1 
ATOM 129  C CG  . LYS A 1 16  ? 179.453 111.514 286.410 1.00 99.22  ? 16  LYS A CG  1 
ATOM 130  C CD  . LYS A 1 16  ? 180.081 112.907 286.420 1.00 108.90 ? 16  LYS A CD  1 
ATOM 131  C CE  . LYS A 1 16  ? 181.378 112.962 287.211 1.00 114.50 ? 16  LYS A CE  1 
ATOM 132  N NZ  . LYS A 1 16  ? 181.227 112.704 288.654 1.00 114.16 ? 16  LYS A NZ  1 
ATOM 133  N N   . GLU A 1 17  ? 175.719 110.199 284.057 1.00 79.86  ? 17  GLU A N   1 
ATOM 134  C CA  . GLU A 1 17  ? 174.337 110.281 283.641 1.00 80.90  ? 17  GLU A CA  1 
ATOM 135  C C   . GLU A 1 17  ? 173.562 109.095 284.200 1.00 76.24  ? 17  GLU A C   1 
ATOM 136  O O   . GLU A 1 17  ? 172.445 109.267 284.670 1.00 81.73  ? 17  GLU A O   1 
ATOM 137  C CB  . GLU A 1 17  ? 174.294 110.367 282.122 1.00 87.72  ? 17  GLU A CB  1 
ATOM 138  C CG  . GLU A 1 17  ? 172.893 110.605 281.579 1.00 99.92  ? 17  GLU A CG  1 
ATOM 139  C CD  . GLU A 1 17  ? 172.886 111.007 280.106 1.00 112.16 ? 17  GLU A CD  1 
ATOM 140  O OE1 . GLU A 1 17  ? 173.288 110.181 279.223 1.00 118.90 ? 17  GLU A OE1 1 
ATOM 141  O OE2 . GLU A 1 17  ? 172.484 112.174 279.842 1.00 114.49 ? 17  GLU A OE2 1 
ATOM 142  N N   . LEU A 1 18  ? 174.166 107.912 284.193 1.00 72.72  ? 18  LEU A N   1 
ATOM 143  C CA  . LEU A 1 18  ? 173.525 106.753 284.778 1.00 69.17  ? 18  LEU A CA  1 
ATOM 144  C C   . LEU A 1 18  ? 173.442 106.905 286.289 1.00 68.26  ? 18  LEU A C   1 
ATOM 145  O O   . LEU A 1 18  ? 172.469 106.472 286.877 1.00 77.08  ? 18  LEU A O   1 
ATOM 146  C CB  . LEU A 1 18  ? 174.265 105.481 284.385 1.00 70.92  ? 18  LEU A CB  1 
ATOM 147  C CG  . LEU A 1 18  ? 174.064 105.022 282.940 1.00 70.26  ? 18  LEU A CG  1 
ATOM 148  C CD1 . LEU A 1 18  ? 175.220 104.152 282.482 1.00 73.27  ? 18  LEU A CD1 1 
ATOM 149  C CD2 . LEU A 1 18  ? 172.757 104.275 282.788 1.00 69.57  ? 18  LEU A CD2 1 
ATOM 150  N N   . SER A 1 19  ? 174.450 107.477 286.934 1.00 71.34  ? 19  SER A N   1 
ATOM 151  C CA  . SER A 1 19  ? 174.411 107.560 288.382 1.00 78.34  ? 19  SER A CA  1 
ATOM 152  C C   . SER A 1 19  ? 173.319 108.535 288.812 1.00 79.69  ? 19  SER A C   1 
ATOM 153  O O   . SER A 1 19  ? 172.642 108.306 289.811 1.00 78.56  ? 19  SER A O   1 
ATOM 154  C CB  . SER A 1 19  ? 175.758 107.941 288.945 1.00 84.29  ? 19  SER A CB  1 
ATOM 155  O OG  . SER A 1 19  ? 175.880 107.540 290.310 1.00 89.41  ? 19  SER A OG  1 
ATOM 156  N N   . ARG A 1 20  ? 173.167 109.623 288.049 1.00 85.08  ? 20  ARG A N   1 
ATOM 157  C CA  . ARG A 1 20  ? 172.109 110.591 288.283 1.00 88.99  ? 20  ARG A CA  1 
ATOM 158  C C   . ARG A 1 20  ? 170.749 109.932 288.083 1.00 80.88  ? 20  ARG A C   1 
ATOM 159  O O   . ARG A 1 20  ? 169.854 110.133 288.897 1.00 88.58  ? 20  ARG A O   1 
ATOM 160  C CB  . ARG A 1 20  ? 172.237 111.843 287.407 1.00 93.92  ? 20  ARG A CB  1 
ATOM 161  C CG  . ARG A 1 20  ? 173.351 112.766 287.891 1.00 101.06 ? 20  ARG A CG  1 
ATOM 162  C CD  . ARG A 1 20  ? 173.241 114.167 287.298 1.00 109.99 ? 20  ARG A CD  1 
ATOM 163  N NE  . ARG A 1 20  ? 173.294 114.137 285.829 1.00 115.21 ? 20  ARG A NE  1 
ATOM 164  C CZ  . ARG A 1 20  ? 174.390 114.302 285.079 1.00 119.35 ? 20  ARG A CZ  1 
ATOM 165  N NH1 . ARG A 1 20  ? 174.298 114.163 283.759 1.00 122.22 ? 20  ARG A NH1 1 
ATOM 166  N NH2 . ARG A 1 20  ? 175.569 114.576 285.636 1.00 118.43 ? 20  ARG A NH2 1 
ATOM 167  N N   . SER A 1 21  ? 170.606 109.127 287.036 1.00 75.79  ? 21  SER A N   1 
ATOM 168  C CA  . SER A 1 21  ? 169.357 108.417 286.799 1.00 74.71  ? 21  SER A CA  1 
ATOM 169  C C   . SER A 1 21  ? 168.998 107.529 287.981 1.00 71.91  ? 21  SER A C   1 
ATOM 170  O O   . SER A 1 21  ? 167.826 107.326 288.249 1.00 76.43  ? 21  SER A O   1 
ATOM 171  C CB  . SER A 1 21  ? 169.387 107.587 285.547 1.00 77.16  ? 21  SER A CB  1 
ATOM 172  O OG  . SER A 1 21  ? 169.454 108.420 284.380 1.00 84.29  ? 21  SER A OG  1 
ATOM 173  N N   . ALA A 1 22  ? 169.986 106.960 288.660 1.00 73.54  ? 22  ALA A N   1 
ATOM 174  C CA  . ALA A 1 22  ? 169.683 106.097 289.785 1.00 75.89  ? 22  ALA A CA  1 
ATOM 175  C C   . ALA A 1 22  ? 169.205 106.939 290.963 1.00 81.64  ? 22  ALA A C   1 
ATOM 176  O O   . ALA A 1 22  ? 168.314 106.515 291.695 1.00 84.89  ? 22  ALA A O   1 
ATOM 177  C CB  . ALA A 1 22  ? 170.885 105.262 290.147 1.00 76.96  ? 22  ALA A CB  1 
ATOM 178  N N   . LYS A 1 23  ? 169.815 108.111 291.166 1.00 86.45  ? 23  LYS A N   1 
ATOM 179  C CA  . LYS A 1 23  ? 169.425 108.964 292.274 1.00 89.85  ? 23  LYS A CA  1 
ATOM 180  C C   . LYS A 1 23  ? 167.995 109.445 292.054 1.00 83.00  ? 23  LYS A C   1 
ATOM 181  O O   . LYS A 1 23  ? 167.198 109.446 292.992 1.00 84.04  ? 23  LYS A O   1 
ATOM 182  C CB  . LYS A 1 23  ? 170.399 110.132 292.466 1.00 97.80  ? 23  LYS A CB  1 
ATOM 183  C CG  . LYS A 1 23  ? 171.677 109.756 293.204 1.00 105.18 ? 23  LYS A CG  1 
ATOM 184  C CD  . LYS A 1 23  ? 172.655 110.922 293.336 1.00 111.49 ? 23  LYS A CD  1 
ATOM 185  C CE  . LYS A 1 23  ? 173.943 110.570 294.057 1.00 115.02 ? 23  LYS A CE  1 
ATOM 186  N NZ  . LYS A 1 23  ? 174.841 109.677 293.307 1.00 114.92 ? 23  LYS A NZ  1 
ATOM 187  N N   . LYS A 1 24  ? 167.676 109.817 290.817 1.00 79.97  ? 24  LYS A N   1 
ATOM 188  C CA  . LYS A 1 24  ? 166.351 110.305 290.486 1.00 83.12  ? 24  LYS A CA  1 
ATOM 189  C C   . LYS A 1 24  ? 165.298 109.232 290.753 1.00 84.35  ? 24  LYS A C   1 
ATOM 190  O O   . LYS A 1 24  ? 164.188 109.551 291.164 1.00 89.56  ? 24  LYS A O   1 
ATOM 191  C CB  . LYS A 1 24  ? 166.259 110.743 289.026 1.00 88.57  ? 24  LYS A CB  1 
ATOM 192  C CG  . LYS A 1 24  ? 164.968 111.453 288.663 1.00 96.94  ? 24  LYS A CG  1 
ATOM 193  C CD  . LYS A 1 24  ? 165.058 112.170 287.320 1.00 105.86 ? 24  LYS A CD  1 
ATOM 194  C CE  . LYS A 1 24  ? 163.851 113.013 286.996 1.00 110.66 ? 24  LYS A CE  1 
ATOM 195  N NZ  . LYS A 1 24  ? 162.684 112.222 286.575 1.00 113.26 ? 24  LYS A NZ  1 
ATOM 196  N N   . CYS A 1 25  ? 165.629 107.964 290.515 1.00 82.83  ? 25  CYS A N   1 
ATOM 197  C CA  . CYS A 1 25  ? 164.724 106.873 290.833 1.00 83.10  ? 25  CYS A CA  1 
ATOM 198  C C   . CYS A 1 25  ? 164.552 106.697 292.338 1.00 81.90  ? 25  CYS A C   1 
ATOM 199  O O   . CYS A 1 25  ? 163.452 106.388 292.772 1.00 91.41  ? 25  CYS A O   1 
ATOM 200  C CB  . CYS A 1 25  ? 165.185 105.567 290.202 1.00 89.18  ? 25  CYS A CB  1 
ATOM 201  S SG  . CYS A 1 25  ? 164.880 105.515 288.410 1.00 99.20  ? 25  CYS A SG  1 
ATOM 202  N N   . ASP A 1 26  ? 165.600 106.882 293.136 1.00 85.89  ? 26  ASP A N   1 
ATOM 203  C CA  . ASP A 1 26  ? 165.465 106.833 294.585 1.00 92.96  ? 26  ASP A CA  1 
ATOM 204  C C   . ASP A 1 26  ? 164.559 107.956 295.090 1.00 87.16  ? 26  ASP A C   1 
ATOM 205  O O   . ASP A 1 26  ? 163.743 107.737 295.977 1.00 84.04  ? 26  ASP A O   1 
ATOM 206  C CB  . ASP A 1 26  ? 166.832 106.870 295.252 1.00 103.60 ? 26  ASP A CB  1 
ATOM 207  C CG  . ASP A 1 26  ? 167.680 105.611 295.084 1.00 112.96 ? 26  ASP A CG  1 
ATOM 208  O OD1 . ASP A 1 26  ? 167.093 104.540 294.755 1.00 113.92 ? 26  ASP A OD1 1 
ATOM 209  O OD2 . ASP A 1 26  ? 168.924 105.703 295.272 1.00 118.16 ? 26  ASP A OD2 1 
ATOM 210  N N   . LYS A 1 27  ? 164.723 109.157 294.535 1.00 87.74  ? 27  LYS A N   1 
ATOM 211  C CA  . LYS A 1 27  ? 163.908 110.300 294.905 1.00 92.11  ? 27  LYS A CA  1 
ATOM 212  C C   . LYS A 1 27  ? 162.435 109.997 294.626 1.00 90.28  ? 27  LYS A C   1 
ATOM 213  O O   . LYS A 1 27  ? 161.584 110.215 295.493 1.00 92.74  ? 27  LYS A O   1 
ATOM 214  C CB  . LYS A 1 27  ? 164.429 111.545 294.179 1.00 95.81  ? 27  LYS A CB  1 
ATOM 215  C CG  . LYS A 1 27  ? 163.742 112.852 294.531 1.00 102.17 ? 27  LYS A CG  1 
ATOM 216  C CD  . LYS A 1 27  ? 164.285 114.040 293.740 1.00 108.49 ? 27  LYS A CD  1 
ATOM 217  C CE  . LYS A 1 27  ? 163.538 115.327 293.995 1.00 112.55 ? 27  LYS A CE  1 
ATOM 218  N NZ  . LYS A 1 27  ? 163.741 115.858 295.353 1.00 114.59 ? 27  LYS A NZ  1 
ATOM 219  N N   . GLU A 1 28  ? 162.137 109.466 293.439 1.00 89.91  ? 28  GLU A N   1 
ATOM 220  C CA  . GLU A 1 28  ? 160.756 109.254 293.018 1.00 89.90  ? 28  GLU A CA  1 
ATOM 221  C C   . GLU A 1 28  ? 160.138 108.033 293.692 1.00 83.91  ? 28  GLU A C   1 
ATOM 222  O O   . GLU A 1 28  ? 158.934 108.005 293.900 1.00 92.71  ? 28  GLU A O   1 
ATOM 223  C CB  . GLU A 1 28  ? 160.643 109.156 291.499 1.00 92.14  ? 28  GLU A CB  1 
ATOM 224  C CG  . GLU A 1 28  ? 160.814 110.524 290.850 1.00 104.47 ? 28  GLU A CG  1 
ATOM 225  C CD  . GLU A 1 28  ? 160.756 110.544 289.328 1.00 115.91 ? 28  GLU A CD  1 
ATOM 226  O OE1 . GLU A 1 28  ? 160.504 109.463 288.696 1.00 121.31 ? 28  GLU A OE1 1 
ATOM 227  O OE2 . GLU A 1 28  ? 160.961 111.666 288.774 1.00 120.57 ? 28  GLU A OE2 1 
ATOM 228  N N   . GLU A 1 29  ? 160.926 107.028 294.040 1.00 81.54  ? 29  GLU A N   1 
ATOM 229  C CA  . GLU A 1 29  ? 160.412 105.891 294.779 1.00 84.01  ? 29  GLU A CA  1 
ATOM 230  C C   . GLU A 1 29  ? 160.004 106.287 296.194 1.00 87.27  ? 29  GLU A C   1 
ATOM 231  O O   . GLU A 1 29  ? 159.039 105.734 296.741 1.00 92.13  ? 29  GLU A O   1 
ATOM 232  C CB  . GLU A 1 29  ? 161.479 104.805 294.795 1.00 91.69  ? 29  GLU A CB  1 
ATOM 233  C CG  . GLU A 1 29  ? 161.039 103.485 295.425 1.00 99.26  ? 29  GLU A CG  1 
ATOM 234  C CD  . GLU A 1 29  ? 161.694 103.100 296.741 1.00 108.65 ? 29  GLU A CD  1 
ATOM 235  O OE1 . GLU A 1 29  ? 162.764 103.673 297.066 1.00 113.12 ? 29  GLU A OE1 1 
ATOM 236  O OE2 . GLU A 1 29  ? 161.151 102.193 297.421 1.00 112.95 ? 29  GLU A OE2 1 
ATOM 237  N N   . LYS A 1 30  ? 160.748 107.214 296.800 1.00 94.09  ? 30  LYS A N   1 
ATOM 238  C CA  . LYS A 1 30  ? 160.386 107.790 298.087 1.00 95.89  ? 30  LYS A CA  1 
ATOM 239  C C   . LYS A 1 30  ? 159.093 108.606 297.974 1.00 88.87  ? 30  LYS A C   1 
ATOM 240  O O   . LYS A 1 30  ? 158.269 108.581 298.882 1.00 87.92  ? 30  LYS A O   1 
ATOM 241  C CB  . LYS A 1 30  ? 161.588 108.608 298.575 1.00 101.82 ? 30  LYS A CB  1 
ATOM 242  C CG  . LYS A 1 30  ? 161.442 109.216 299.955 1.00 110.35 ? 30  LYS A CG  1 
ATOM 243  C CD  . LYS A 1 30  ? 162.678 109.982 300.419 1.00 114.76 ? 30  LYS A CD  1 
ATOM 244  C CE  . LYS A 1 30  ? 162.460 110.624 301.772 1.00 118.87 ? 30  LYS A CE  1 
ATOM 245  N NZ  . LYS A 1 30  ? 163.632 111.375 302.238 1.00 120.40 ? 30  LYS A NZ  1 
ATOM 246  N N   . ALA A 1 31  ? 158.918 109.323 296.864 1.00 84.90  ? 31  ALA A N   1 
ATOM 247  C CA  . ALA A 1 31  ? 157.728 110.133 296.653 1.00 86.43  ? 31  ALA A CA  1 
ATOM 248  C C   . ALA A 1 31  ? 156.495 109.254 296.447 1.00 85.17  ? 31  ALA A C   1 
ATOM 249  O O   . ALA A 1 31  ? 155.451 109.544 297.017 1.00 94.69  ? 31  ALA A O   1 
ATOM 250  C CB  . ALA A 1 31  ? 157.936 111.086 295.489 1.00 87.58  ? 31  ALA A CB  1 
ATOM 251  N N   . GLU A 1 32  ? 156.599 108.194 295.648 1.00 81.34  ? 32  GLU A N   1 
ATOM 252  C CA  . GLU A 1 32  ? 155.467 107.317 295.402 1.00 83.16  ? 32  GLU A CA  1 
ATOM 253  C C   . GLU A 1 32  ? 155.049 106.605 296.690 1.00 82.41  ? 32  GLU A C   1 
ATOM 254  O O   . GLU A 1 32  ? 153.863 106.376 296.899 1.00 89.11  ? 32  GLU A O   1 
ATOM 255  C CB  . GLU A 1 32  ? 155.750 106.325 294.269 1.00 87.68  ? 32  GLU A CB  1 
ATOM 256  C CG  . GLU A 1 32  ? 155.923 106.975 292.896 1.00 95.54  ? 32  GLU A CG  1 
ATOM 257  C CD  . GLU A 1 32  ? 154.683 107.607 292.261 1.00 106.67 ? 32  GLU A CD  1 
ATOM 258  O OE1 . GLU A 1 32  ? 153.646 106.867 292.136 1.00 106.53 ? 32  GLU A OE1 1 
ATOM 259  O OE2 . GLU A 1 32  ? 154.770 108.834 291.844 1.00 112.83 ? 32  GLU A OE2 1 
ATOM 260  N N   . LYS A 1 33  ? 155.991 106.255 297.561 1.00 82.73  ? 33  LYS A N   1 
ATOM 261  C CA  . LYS A 1 33  ? 155.654 105.663 298.849 1.00 85.61  ? 33  LYS A CA  1 
ATOM 262  C C   . LYS A 1 33  ? 154.769 106.591 299.681 1.00 85.40  ? 33  LYS A C   1 
ATOM 263  O O   . LYS A 1 33  ? 153.879 106.115 300.381 1.00 87.99  ? 33  LYS A O   1 
ATOM 264  C CB  . LYS A 1 33  ? 156.930 105.315 299.621 1.00 92.41  ? 33  LYS A CB  1 
ATOM 265  C CG  . LYS A 1 33  ? 157.416 103.891 299.418 1.00 97.34  ? 33  LYS A CG  1 
ATOM 266  C CD  . LYS A 1 33  ? 158.721 103.616 300.160 1.00 103.42 ? 33  LYS A CD  1 
ATOM 267  C CE  . LYS A 1 33  ? 159.000 102.166 300.446 1.00 105.83 ? 33  LYS A CE  1 
ATOM 268  N NZ  . LYS A 1 33  ? 159.192 101.365 299.233 1.00 108.23 ? 33  LYS A NZ  1 
ATOM 269  N N   . ALA A 1 34  ? 155.020 107.902 299.623 1.00 82.37  ? 34  ALA A N   1 
ATOM 270  C CA  . ALA A 1 34  ? 154.195 108.860 300.333 1.00 85.27  ? 34  ALA A CA  1 
ATOM 271  C C   . ALA A 1 34  ? 152.765 108.866 299.775 1.00 85.68  ? 34  ALA A C   1 
ATOM 272  O O   . ALA A 1 34  ? 151.817 109.047 300.536 1.00 92.55  ? 34  ALA A O   1 
ATOM 273  C CB  . ALA A 1 34  ? 154.854 110.226 300.275 1.00 89.18  ? 34  ALA A CB  1 
ATOM 274  N N   . LYS A 1 35  ? 152.606 108.637 298.467 1.00 80.98  ? 35  LYS A N   1 
ATOM 275  C CA  . LYS A 1 35  ? 151.304 108.664 297.823 1.00 78.88  ? 35  LYS A CA  1 
ATOM 276  C C   . LYS A 1 35  ? 150.511 107.400 298.131 1.00 76.53  ? 35  LYS A C   1 
ATOM 277  O O   . LYS A 1 35  ? 149.285 107.457 298.144 1.00 83.79  ? 35  LYS A O   1 
ATOM 278  C CB  . LYS A 1 35  ? 151.456 108.873 296.316 1.00 79.76  ? 35  LYS A CB  1 
ATOM 279  C CG  . LYS A 1 35  ? 152.054 110.218 295.939 1.00 82.28  ? 35  LYS A CG  1 
ATOM 280  C CD  . LYS A 1 35  ? 152.273 110.339 294.440 1.00 84.48  ? 35  LYS A CD  1 
ATOM 281  C CE  . LYS A 1 35  ? 153.112 111.527 294.067 1.00 90.17  ? 35  LYS A CE  1 
ATOM 282  N NZ  . LYS A 1 35  ? 153.501 111.503 292.650 1.00 92.04  ? 35  LYS A NZ  1 
ATOM 283  N N   . ILE A 1 36  ? 151.180 106.271 298.356 1.00 77.00  ? 36  ILE A N   1 
ATOM 284  C CA  . ILE A 1 36  ? 150.487 105.057 298.752 1.00 81.40  ? 36  ILE A CA  1 
ATOM 285  C C   . ILE A 1 36  ? 149.818 105.329 300.092 1.00 87.45  ? 36  ILE A C   1 
ATOM 286  O O   . ILE A 1 36  ? 148.649 105.001 300.272 1.00 91.82  ? 36  ILE A O   1 
ATOM 287  C CB  . ILE A 1 36  ? 151.421 103.832 298.841 1.00 87.30  ? 36  ILE A CB  1 
ATOM 288  C CG1 . ILE A 1 36  ? 152.136 103.510 297.522 1.00 86.88  ? 36  ILE A CG1 1 
ATOM 289  C CG2 . ILE A 1 36  ? 150.660 102.598 299.341 1.00 89.51  ? 36  ILE A CG2 1 
ATOM 290  C CD1 . ILE A 1 36  ? 153.336 102.592 297.697 1.00 90.17  ? 36  ILE A CD1 1 
ATOM 291  N N   . LYS A 1 37  ? 150.562 105.927 301.026 1.00 94.71  ? 37  LYS A N   1 
ATOM 292  C CA  . LYS A 1 37  ? 150.053 106.175 302.367 1.00 102.08 ? 37  LYS A CA  1 
ATOM 293  C C   . LYS A 1 37  ? 148.752 106.979 302.293 1.00 99.85  ? 37  LYS A C   1 
ATOM 294  O O   . LYS A 1 37  ? 147.742 106.563 302.858 1.00 100.57 ? 37  LYS A O   1 
ATOM 295  C CB  . LYS A 1 37  ? 151.160 106.843 303.193 1.00 109.29 ? 37  LYS A CB  1 
ATOM 296  C CG  . LYS A 1 37  ? 150.844 106.972 304.679 1.00 115.70 ? 37  LYS A CG  1 
ATOM 297  C CD  . LYS A 1 37  ? 151.996 107.569 305.481 1.00 118.85 ? 37  LYS A CD  1 
ATOM 298  C CE  . LYS A 1 37  ? 151.674 107.682 306.947 1.00 120.47 ? 37  LYS A CE  1 
ATOM 299  N NZ  . LYS A 1 37  ? 152.789 108.252 307.714 1.00 121.70 ? 37  LYS A NZ  1 
ATOM 300  N N   . LYS A 1 38  ? 148.772 108.099 301.562 1.00 96.67  ? 38  LYS A N   1 
ATOM 301  C CA  . LYS A 1 38  ? 147.603 108.949 301.409 1.00 98.92  ? 38  LYS A CA  1 
ATOM 302  C C   . LYS A 1 38  ? 146.432 108.187 300.791 1.00 98.48  ? 38  LYS A C   1 
ATOM 303  O O   . LYS A 1 38  ? 145.307 108.311 301.265 1.00 106.72 ? 38  LYS A O   1 
ATOM 304  C CB  . LYS A 1 38  ? 147.970 110.195 300.601 1.00 101.82 ? 38  LYS A CB  1 
ATOM 305  C CG  . LYS A 1 38  ? 148.819 111.184 301.384 1.00 107.81 ? 38  LYS A CG  1 
ATOM 306  C CD  . LYS A 1 38  ? 149.130 112.459 300.604 1.00 113.85 ? 38  LYS A CD  1 
ATOM 307  C CE  . LYS A 1 38  ? 149.843 113.523 301.421 1.00 118.37 ? 38  LYS A CE  1 
ATOM 308  N NZ  . LYS A 1 38  ? 151.232 113.171 301.771 1.00 120.08 ? 38  LYS A NZ  1 
ATOM 309  N N   . ALA A 1 39  ? 146.687 107.400 299.750 1.00 96.09  ? 39  ALA A N   1 
ATOM 310  C CA  . ALA A 1 39  ? 145.634 106.670 299.059 1.00 94.97  ? 39  ALA A CA  1 
ATOM 311  C C   . ALA A 1 39  ? 145.015 105.594 299.952 1.00 92.65  ? 39  ALA A C   1 
ATOM 312  O O   . ALA A 1 39  ? 143.822 105.334 299.832 1.00 99.13  ? 39  ALA A O   1 
ATOM 313  C CB  . ALA A 1 39  ? 146.185 106.077 297.777 1.00 96.55  ? 39  ALA A CB  1 
ATOM 314  N N   . ILE A 1 40  ? 145.804 104.956 300.819 1.00 94.62  ? 40  ILE A N   1 
ATOM 315  C CA  . ILE A 1 40  ? 145.278 103.956 301.742 1.00 100.68 ? 40  ILE A CA  1 
ATOM 316  C C   . ILE A 1 40  ? 144.351 104.629 302.762 1.00 104.32 ? 40  ILE A C   1 
ATOM 317  O O   . ILE A 1 40  ? 143.283 104.093 303.073 1.00 103.39 ? 40  ILE A O   1 
ATOM 318  C CB  . ILE A 1 40  ? 146.429 103.179 302.422 1.00 103.20 ? 40  ILE A CB  1 
ATOM 319  C CG1 . ILE A 1 40  ? 147.204 102.272 301.450 1.00 103.02 ? 40  ILE A CG1 1 
ATOM 320  C CG2 . ILE A 1 40  ? 145.934 102.368 303.622 1.00 105.81 ? 40  ILE A CG2 1 
ATOM 321  C CD1 . ILE A 1 40  ? 146.435 101.060 300.940 1.00 104.82 ? 40  ILE A CD1 1 
ATOM 322  N N   . GLN A 1 41  ? 144.751 105.797 303.283 1.00 107.57 ? 41  GLN A N   1 
ATOM 323  C CA  . GLN A 1 41  ? 143.954 106.521 304.270 1.00 111.85 ? 41  GLN A CA  1 
ATOM 324  C C   . GLN A 1 41  ? 142.598 106.954 303.701 1.00 110.70 ? 41  GLN A C   1 
ATOM 325  O O   . GLN A 1 41  ? 141.616 106.991 304.440 1.00 114.81 ? 41  GLN A O   1 
ATOM 326  C CB  . GLN A 1 41  ? 144.754 107.695 304.838 1.00 115.34 ? 41  GLN A CB  1 
ATOM 327  C CG  . GLN A 1 41  ? 145.859 107.242 305.791 1.00 120.86 ? 41  GLN A CG  1 
ATOM 328  C CD  . GLN A 1 41  ? 146.697 108.378 306.343 1.00 127.28 ? 41  GLN A CD  1 
ATOM 329  O OE1 . GLN A 1 41  ? 146.706 109.498 305.808 1.00 129.01 ? 41  GLN A OE1 1 
ATOM 330  N NE2 . GLN A 1 41  ? 147.435 108.098 307.412 1.00 129.44 ? 41  GLN A NE2 1 
ATOM 331  N N   . LYS A 1 42  ? 142.543 107.263 302.399 1.00 106.84 ? 42  LYS A N   1 
ATOM 332  C CA  . LYS A 1 42  ? 141.305 107.634 301.718 1.00 107.86 ? 42  LYS A CA  1 
ATOM 333  C C   . LYS A 1 42  ? 140.527 106.431 301.171 1.00 106.75 ? 42  LYS A C   1 
ATOM 334  O O   . LYS A 1 42  ? 139.478 106.615 300.547 1.00 110.07 ? 42  LYS A O   1 
ATOM 335  C CB  . LYS A 1 42  ? 141.611 108.567 300.545 1.00 110.19 ? 42  LYS A CB  1 
ATOM 336  C CG  . LYS A 1 42  ? 142.034 109.957 300.980 1.00 116.07 ? 42  LYS A CG  1 
ATOM 337  C CD  . LYS A 1 42  ? 142.329 110.877 299.797 1.00 120.98 ? 42  LYS A CD  1 
ATOM 338  C CE  . LYS A 1 42  ? 142.450 112.332 300.184 1.00 125.47 ? 42  LYS A CE  1 
ATOM 339  N NZ  . LYS A 1 42  ? 143.597 112.618 301.058 1.00 127.84 ? 42  LYS A NZ  1 
ATOM 340  N N   . GLY A 1 43  ? 141.045 105.212 301.367 1.00 105.36 ? 43  GLY A N   1 
ATOM 341  C CA  . GLY A 1 43  ? 140.409 104.000 300.868 1.00 106.91 ? 43  GLY A CA  1 
ATOM 342  C C   . GLY A 1 43  ? 140.432 103.852 299.339 1.00 109.20 ? 43  GLY A C   1 
ATOM 343  O O   . GLY A 1 43  ? 139.719 102.998 298.811 1.00 112.68 ? 43  GLY A O   1 
ATOM 344  N N   . ASN A 1 44  ? 141.247 104.650 298.626 1.00 107.43 ? 44  ASN A N   1 
ATOM 345  C CA  . ASN A 1 44  ? 141.378 104.575 297.173 1.00 106.38 ? 44  ASN A CA  1 
ATOM 346  C C   . ASN A 1 44  ? 142.298 103.419 296.764 1.00 105.05 ? 44  ASN A C   1 
ATOM 347  O O   . ASN A 1 44  ? 143.395 103.664 296.269 1.00 110.23 ? 44  ASN A O   1 
ATOM 348  C CB  . ASN A 1 44  ? 141.932 105.880 296.594 1.00 108.56 ? 44  ASN A CB  1 
ATOM 349  C CG  . ASN A 1 44  ? 141.078 107.111 296.830 1.00 116.86 ? 44  ASN A CG  1 
ATOM 350  O OD1 . ASN A 1 44  ? 141.627 108.209 297.005 1.00 118.41 ? 44  ASN A OD1 1 
ATOM 351  N ND2 . ASN A 1 44  ? 139.755 106.994 296.770 1.00 120.52 ? 44  ASN A ND2 1 
ATOM 352  N N   . MET A 1 45  ? 141.855 102.165 296.923 1.00 102.17 ? 45  MET A N   1 
ATOM 353  C CA  . MET A 1 45  ? 142.731 101.001 296.813 1.00 101.06 ? 45  MET A CA  1 
ATOM 354  C C   . MET A 1 45  ? 143.273 100.786 295.399 1.00 96.98  ? 45  MET A C   1 
ATOM 355  O O   . MET A 1 45  ? 144.341 100.205 295.248 1.00 99.67  ? 45  MET A O   1 
ATOM 356  C CB  . MET A 1 45  ? 142.004 99.738  297.287 1.00 107.59 ? 45  MET A CB  1 
ATOM 357  C CG  . MET A 1 45  ? 141.785 99.742  298.784 1.00 115.58 ? 45  MET A CG  1 
ATOM 358  S SD  . MET A 1 45  ? 143.356 99.694  299.670 1.00 127.00 ? 45  MET A SD  1 
ATOM 359  C CE  . MET A 1 45  ? 142.753 100.226 301.281 1.00 131.62 ? 45  MET A CE  1 
ATOM 360  N N   . GLU A 1 46  ? 142.576 101.265 294.370 1.00 96.14  ? 46  GLU A N   1 
ATOM 361  C CA  . GLU A 1 46  ? 143.070 101.174 293.005 1.00 96.09  ? 46  GLU A CA  1 
ATOM 362  C C   . GLU A 1 46  ? 144.242 102.134 292.805 1.00 85.58  ? 46  GLU A C   1 
ATOM 363  O O   . GLU A 1 46  ? 145.203 101.779 292.145 1.00 87.81  ? 46  GLU A O   1 
ATOM 364  C CB  . GLU A 1 46  ? 141.885 101.420 292.068 1.00 105.38 ? 46  GLU A CB  1 
ATOM 365  C CG  . GLU A 1 46  ? 142.236 101.386 290.583 1.00 111.90 ? 46  GLU A CG  1 
ATOM 366  C CD  . GLU A 1 46  ? 141.055 101.211 289.634 1.00 119.87 ? 46  GLU A CD  1 
ATOM 367  O OE1 . GLU A 1 46  ? 139.926 100.958 290.127 1.00 125.20 ? 46  GLU A OE1 1 
ATOM 368  O OE2 . GLU A 1 46  ? 141.267 101.321 288.397 1.00 122.89 ? 46  GLU A OE2 1 
ATOM 369  N N   . VAL A 1 47  ? 144.159 103.337 293.372 1.00 81.63  ? 47  VAL A N   1 
ATOM 370  C CA  . VAL A 1 47  ? 145.226 104.323 293.292 1.00 80.04  ? 47  VAL A CA  1 
ATOM 371  C C   . VAL A 1 47  ? 146.399 103.883 294.160 1.00 79.54  ? 47  VAL A C   1 
ATOM 372  O O   . VAL A 1 47  ? 147.547 104.092 293.782 1.00 81.81  ? 47  VAL A O   1 
ATOM 373  C CB  . VAL A 1 47  ? 144.697 105.711 293.704 1.00 84.23  ? 47  VAL A CB  1 
ATOM 374  C CG1 . VAL A 1 47  ? 145.772 106.782 293.797 1.00 83.76  ? 47  VAL A CG1 1 
ATOM 375  C CG2 . VAL A 1 47  ? 143.621 106.193 292.749 1.00 88.40  ? 47  VAL A CG2 1 
ATOM 376  N N   . ALA A 1 48  ? 146.120 103.289 295.319 1.00 80.32  ? 48  ALA A N   1 
ATOM 377  C CA  . ALA A 1 48  ? 147.176 102.772 296.167 1.00 84.20  ? 48  ALA A CA  1 
ATOM 378  C C   . ALA A 1 48  ? 148.016 101.768 295.372 1.00 83.91  ? 48  ALA A C   1 
ATOM 379  O O   . ALA A 1 48  ? 149.247 101.886 295.328 1.00 87.66  ? 48  ALA A O   1 
ATOM 380  C CB  . ALA A 1 48  ? 146.582 102.184 297.430 1.00 85.56  ? 48  ALA A CB  1 
ATOM 381  N N   . ARG A 1 49  ? 147.353 100.856 294.659 1.00 80.16  ? 49  ARG A N   1 
ATOM 382  C CA  . ARG A 1 49  ? 148.051 99.856  293.864 1.00 79.35  ? 49  ARG A CA  1 
ATOM 383  C C   . ARG A 1 49  ? 148.871 100.491 292.737 1.00 73.21  ? 49  ARG A C   1 
ATOM 384  O O   . ARG A 1 49  ? 149.983 100.053 292.476 1.00 76.91  ? 49  ARG A O   1 
ATOM 385  C CB  . ARG A 1 49  ? 147.053 98.819  293.352 1.00 83.95  ? 49  ARG A CB  1 
ATOM 386  C CG  . ARG A 1 49  ? 147.626 97.955  292.243 1.00 90.00  ? 49  ARG A CG  1 
ATOM 387  C CD  . ARG A 1 49  ? 146.743 96.749  291.992 1.00 99.53  ? 49  ARG A CD  1 
ATOM 388  N NE  . ARG A 1 49  ? 146.917 95.739  293.044 1.00 102.59 ? 49  ARG A NE  1 
ATOM 389  C CZ  . ARG A 1 49  ? 147.929 94.876  293.127 1.00 106.62 ? 49  ARG A CZ  1 
ATOM 390  N NH1 . ARG A 1 49  ? 147.959 94.015  294.133 1.00 107.10 ? 49  ARG A NH1 1 
ATOM 391  N NH2 . ARG A 1 49  ? 148.900 94.855  292.216 1.00 105.42 ? 49  ARG A NH2 1 
ATOM 392  N N   . ILE A 1 50  ? 148.348 101.501 292.050 1.00 70.28  ? 50  ILE A N   1 
ATOM 393  C CA  . ILE A 1 50  ? 149.100 102.147 290.984 1.00 69.46  ? 50  ILE A CA  1 
ATOM 394  C C   . ILE A 1 50  ? 150.400 102.719 291.549 1.00 72.05  ? 50  ILE A C   1 
ATOM 395  O O   . ILE A 1 50  ? 151.450 102.561 290.942 1.00 75.55  ? 50  ILE A O   1 
ATOM 396  C CB  . ILE A 1 50  ? 148.238 103.204 290.269 1.00 73.05  ? 50  ILE A CB  1 
ATOM 397  C CG1 . ILE A 1 50  ? 147.151 102.528 289.435 1.00 77.68  ? 50  ILE A CG1 1 
ATOM 398  C CG2 . ILE A 1 50  ? 149.065 104.159 289.406 1.00 73.92  ? 50  ILE A CG2 1 
ATOM 399  C CD1 . ILE A 1 50  ? 145.999 103.442 289.050 1.00 84.03  ? 50  ILE A CD1 1 
ATOM 400  N N   . HIS A 1 51  ? 150.350 103.384 292.703 1.00 75.63  ? 51  HIS A N   1 
ATOM 401  C CA  . HIS A 1 51  ? 151.557 103.944 293.288 1.00 74.95  ? 51  HIS A CA  1 
ATOM 402  C C   . HIS A 1 51  ? 152.473 102.826 293.780 1.00 73.01  ? 51  HIS A C   1 
ATOM 403  O O   . HIS A 1 51  ? 153.685 102.969 293.707 1.00 76.32  ? 51  HIS A O   1 
ATOM 404  C CB  . HIS A 1 51  ? 151.214 104.957 294.382 1.00 74.79  ? 51  HIS A CB  1 
ATOM 405  C CG  . HIS A 1 51  ? 150.540 106.173 293.866 1.00 68.88  ? 51  HIS A CG  1 
ATOM 406  N ND1 . HIS A 1 51  ? 151.089 107.046 292.960 1.00 69.07  ? 51  HIS A ND1 1 
ATOM 407  C CD2 . HIS A 1 51  ? 149.330 106.628 294.139 1.00 71.51  ? 51  HIS A CD2 1 
ATOM 408  C CE1 . HIS A 1 51  ? 150.223 108.012 292.718 1.00 73.57  ? 51  HIS A CE1 1 
ATOM 409  N NE2 . HIS A 1 51  ? 149.148 107.782 293.429 1.00 75.69  ? 51  HIS A NE2 1 
ATOM 410  N N   . ALA A 1 52  ? 151.906 101.723 294.274 1.00 71.77  ? 52  ALA A N   1 
ATOM 411  C CA  . ALA A 1 52  ? 152.728 100.621 294.744 1.00 70.61  ? 52  ALA A CA  1 
ATOM 412  C C   . ALA A 1 52  ? 153.561 100.116 293.581 1.00 71.56  ? 52  ALA A C   1 
ATOM 413  O O   . ALA A 1 52  ? 154.782 100.009 293.718 1.00 80.23  ? 52  ALA A O   1 
ATOM 414  C CB  . ALA A 1 52  ? 151.884 99.543  295.376 1.00 73.00  ? 52  ALA A CB  1 
ATOM 415  N N   . GLU A 1 53  ? 152.935 99.923  292.418 1.00 76.38  ? 53  GLU A N   1 
ATOM 416  C CA  . GLU A 1 53  ? 153.641 99.406  291.251 1.00 78.31  ? 53  GLU A CA  1 
ATOM 417  C C   . GLU A 1 53  ? 154.721 100.404 290.835 1.00 68.65  ? 53  GLU A C   1 
ATOM 418  O O   . GLU A 1 53  ? 155.835 100.003 290.568 1.00 72.54  ? 53  GLU A O   1 
ATOM 419  C CB  . GLU A 1 53  ? 152.682 99.034  290.117 1.00 83.52  ? 53  GLU A CB  1 
ATOM 420  C CG  . GLU A 1 53  ? 151.780 97.849  290.467 1.00 93.90  ? 53  GLU A CG  1 
ATOM 421  C CD  . GLU A 1 53  ? 150.569 97.593  289.557 1.00 105.88 ? 53  GLU A CD  1 
ATOM 422  O OE1 . GLU A 1 53  ? 150.366 98.349  288.565 1.00 106.88 ? 53  GLU A OE1 1 
ATOM 423  O OE2 . GLU A 1 53  ? 149.803 96.619  289.833 1.00 110.87 ? 53  GLU A OE2 1 
ATOM 424  N N   . ASN A 1 54  ? 154.431 101.699 290.834 1.00 67.31  ? 54  ASN A N   1 
ATOM 425  C CA  . ASN A 1 54  ? 155.449 102.684 290.530 1.00 67.50  ? 54  ASN A CA  1 
ATOM 426  C C   . ASN A 1 54  ? 156.617 102.546 291.504 1.00 71.85  ? 54  ASN A C   1 
ATOM 427  O O   . ASN A 1 54  ? 157.765 102.588 291.089 1.00 81.91  ? 54  ASN A O   1 
ATOM 428  C CB  . ASN A 1 54  ? 154.900 104.103 290.579 1.00 72.50  ? 54  ASN A CB  1 
ATOM 429  C CG  . ASN A 1 54  ? 153.942 104.406 289.455 1.00 79.28  ? 54  ASN A CG  1 
ATOM 430  O OD1 . ASN A 1 54  ? 153.893 103.679 288.454 1.00 83.88  ? 54  ASN A OD1 1 
ATOM 431  N ND2 . ASN A 1 54  ? 153.186 105.487 289.583 1.00 84.09  ? 54  ASN A ND2 1 
ATOM 432  N N   . ALA A 1 55  ? 156.340 102.436 292.800 1.00 71.69  ? 55  ALA A N   1 
ATOM 433  C CA  . ALA A 1 55  ? 157.394 102.459 293.789 1.00 66.08  ? 55  ALA A CA  1 
ATOM 434  C C   . ALA A 1 55  ? 158.308 101.262 293.562 1.00 62.73  ? 55  ALA A C   1 
ATOM 435  O O   . ALA A 1 55  ? 159.520 101.431 293.563 1.00 62.79  ? 55  ALA A O   1 
ATOM 436  C CB  . ALA A 1 55  ? 156.771 102.485 295.164 1.00 73.79  ? 55  ALA A CB  1 
ATOM 437  N N   . ILE A 1 56  ? 157.739 100.074 293.329 1.00 63.38  ? 56  ILE A N   1 
ATOM 438  C CA  . ILE A 1 56  ? 158.539 98.867  293.138 1.00 63.10  ? 56  ILE A CA  1 
ATOM 439  C C   . ILE A 1 56  ? 159.298 98.935  291.811 1.00 58.82  ? 56  ILE A C   1 
ATOM 440  O O   . ILE A 1 56  ? 160.411 98.441  291.716 1.00 63.30  ? 56  ILE A O   1 
ATOM 441  C CB  . ILE A 1 56  ? 157.650 97.617  293.238 1.00 64.81  ? 56  ILE A CB  1 
ATOM 442  C CG1 . ILE A 1 56  ? 157.107 97.406  294.651 1.00 70.41  ? 56  ILE A CG1 1 
ATOM 443  C CG2 . ILE A 1 56  ? 158.369 96.369  292.748 1.00 69.95  ? 56  ILE A CG2 1 
ATOM 444  C CD1 . ILE A 1 56  ? 158.151 97.229  295.738 1.00 75.60  ? 56  ILE A CD1 1 
ATOM 445  N N   . ARG A 1 57  ? 158.734 99.579  290.793 1.00 60.59  ? 57  ARG A N   1 
ATOM 446  C CA  . ARG A 1 57  ? 159.388 99.700  289.497 1.00 63.34  ? 57  ARG A CA  1 
ATOM 447  C C   . ARG A 1 57  ? 160.562 100.678 289.534 1.00 65.23  ? 57  ARG A C   1 
ATOM 448  O O   . ARG A 1 57  ? 161.470 100.592 288.721 1.00 74.92  ? 57  ARG A O   1 
ATOM 449  C CB  . ARG A 1 57  ? 158.471 100.250 288.402 1.00 66.88  ? 57  ARG A CB  1 
ATOM 450  C CG  . ARG A 1 57  ? 159.147 100.580 287.083 1.00 70.71  ? 57  ARG A CG  1 
ATOM 451  C CD  . ARG A 1 57  ? 158.169 100.757 285.971 1.00 72.46  ? 57  ARG A CD  1 
ATOM 452  N NE  . ARG A 1 57  ? 157.346 101.933 286.241 1.00 75.69  ? 57  ARG A NE  1 
ATOM 453  C CZ  . ARG A 1 57  ? 157.776 103.185 286.161 1.00 81.04  ? 57  ARG A CZ  1 
ATOM 454  N NH1 . ARG A 1 57  ? 156.950 104.170 286.487 1.00 84.98  ? 57  ARG A NH1 1 
ATOM 455  N NH2 . ARG A 1 57  ? 159.010 103.466 285.758 1.00 78.71  ? 57  ARG A NH2 1 
ATOM 456  N N   . GLN A 1 58  ? 160.537 101.655 290.422 1.00 66.17  ? 58  GLN A N   1 
ATOM 457  C CA  . GLN A 1 58  ? 161.622 102.616 290.504 1.00 69.59  ? 58  GLN A CA  1 
ATOM 458  C C   . GLN A 1 58  ? 162.684 102.126 291.479 1.00 67.23  ? 58  GLN A C   1 
ATOM 459  O O   . GLN A 1 58  ? 163.854 102.432 291.303 1.00 70.12  ? 58  GLN A O   1 
ATOM 460  C CB  . GLN A 1 58  ? 161.038 103.996 290.787 1.00 70.97  ? 58  GLN A CB  1 
ATOM 461  C CG  . GLN A 1 58  ? 160.219 104.451 289.589 1.00 81.51  ? 58  GLN A CG  1 
ATOM 462  C CD  . GLN A 1 58  ? 160.048 105.943 289.474 1.00 86.98  ? 58  GLN A CD  1 
ATOM 463  O OE1 . GLN A 1 58  ? 159.015 106.490 289.873 1.00 97.93  ? 58  GLN A OE1 1 
ATOM 464  N NE2 . GLN A 1 58  ? 161.036 106.613 288.894 1.00 86.70  ? 58  GLN A NE2 1 
ATOM 465  N N   . LYS A 1 59  ? 162.286 101.344 292.471 1.00 66.28  ? 59  LYS A N   1 
ATOM 466  C CA  . LYS A 1 59  ? 163.246 100.660 293.309 1.00 70.25  ? 59  LYS A CA  1 
ATOM 467  C C   . LYS A 1 59  ? 164.162 99.817  292.433 1.00 72.89  ? 59  LYS A C   1 
ATOM 468  O O   . LYS A 1 59  ? 165.381 99.887  292.591 1.00 78.45  ? 59  LYS A O   1 
ATOM 469  C CB  . LYS A 1 59  ? 162.506 99.812  294.345 1.00 77.47  ? 59  LYS A CB  1 
ATOM 470  C CG  . LYS A 1 59  ? 163.368 98.937  295.230 1.00 77.91  ? 59  LYS A CG  1 
ATOM 471  C CD  . LYS A 1 59  ? 162.504 98.092  296.152 1.00 90.94  ? 59  LYS A CD  1 
ATOM 472  C CE  . LYS A 1 59  ? 163.288 97.209  297.085 1.00 100.24 ? 59  LYS A CE  1 
ATOM 473  N NZ  . LYS A 1 59  ? 163.924 96.080  296.390 1.00 105.24 ? 59  LYS A NZ  1 
ATOM 474  N N   . ASN A 1 60  ? 163.587 99.070  291.483 1.00 70.87  ? 60  ASN A N   1 
ATOM 475  C CA  . ASN A 1 60  ? 164.360 98.129  290.686 1.00 68.87  ? 60  ASN A CA  1 
ATOM 476  C C   . ASN A 1 60  ? 165.070 98.826  289.531 1.00 65.53  ? 60  ASN A C   1 
ATOM 477  O O   . ASN A 1 60  ? 166.165 98.421  289.195 1.00 70.71  ? 60  ASN A O   1 
ATOM 478  C CB  . ASN A 1 60  ? 163.487 96.984  290.204 1.00 71.44  ? 60  ASN A CB  1 
ATOM 479  C CG  . ASN A 1 60  ? 163.032 96.117  291.349 1.00 73.82  ? 60  ASN A CG  1 
ATOM 480  O OD1 . ASN A 1 60  ? 163.703 96.058  292.392 1.00 76.62  ? 60  ASN A OD1 1 
ATOM 481  N ND2 . ASN A 1 60  ? 161.914 95.425  291.173 1.00 78.18  ? 60  ASN A ND2 1 
ATOM 482  N N   . GLN A 1 61  ? 164.467 99.844  288.916 1.00 65.75  ? 61  GLN A N   1 
ATOM 483  C CA  . GLN A 1 61  ? 165.170 100.642 287.929 1.00 67.49  ? 61  GLN A CA  1 
ATOM 484  C C   . GLN A 1 61  ? 166.435 101.227 288.545 1.00 71.07  ? 61  GLN A C   1 
ATOM 485  O O   . GLN A 1 61  ? 167.468 101.248 287.889 1.00 77.99  ? 61  GLN A O   1 
ATOM 486  C CB  . GLN A 1 61  ? 164.360 101.812 287.372 1.00 75.32  ? 61  GLN A CB  1 
ATOM 487  C CG  . GLN A 1 61  ? 163.326 101.391 286.336 1.00 78.10  ? 61  GLN A CG  1 
ATOM 488  C CD  . GLN A 1 61  ? 162.406 102.497 285.854 1.00 81.01  ? 61  GLN A CD  1 
ATOM 489  O OE1 . GLN A 1 61  ? 161.376 102.215 285.225 1.00 86.58  ? 61  GLN A OE1 1 
ATOM 490  N NE2 . GLN A 1 61  ? 162.739 103.753 286.128 1.00 80.00  ? 61  GLN A NE2 1 
ATOM 491  N N   . ALA A 1 62  ? 166.363 101.720 289.785 1.00 71.71  ? 62  ALA A N   1 
ATOM 492  C CA  . ALA A 1 62  ? 167.524 102.338 290.398 1.00 69.91  ? 62  ALA A CA  1 
ATOM 493  C C   . ALA A 1 62  ? 168.674 101.342 290.405 1.00 65.66  ? 62  ALA A C   1 
ATOM 494  O O   . ALA A 1 62  ? 169.786 101.707 290.053 1.00 69.88  ? 62  ALA A O   1 
ATOM 495  C CB  . ALA A 1 62  ? 167.206 102.829 291.791 1.00 73.33  ? 62  ALA A CB  1 
ATOM 496  N N   . VAL A 1 63  ? 168.405 100.100 290.794 1.00 63.25  ? 63  VAL A N   1 
ATOM 497  C CA  . VAL A 1 63  ? 169.466 99.120  290.925 1.00 62.62  ? 63  VAL A CA  1 
ATOM 498  C C   . VAL A 1 63  ? 170.073 98.868  289.553 1.00 62.70  ? 63  VAL A C   1 
ATOM 499  O O   . VAL A 1 63  ? 171.274 98.678  289.439 1.00 71.78  ? 63  VAL A O   1 
ATOM 500  C CB  . VAL A 1 63  ? 168.968 97.813  291.560 1.00 67.00  ? 63  VAL A CB  1 
ATOM 501  C CG1 . VAL A 1 63  ? 169.982 96.681  291.478 1.00 68.34  ? 63  VAL A CG1 1 
ATOM 502  C CG2 . VAL A 1 63  ? 168.540 98.044  292.998 1.00 71.76  ? 63  VAL A CG2 1 
ATOM 503  N N   . ASN A 1 64  ? 169.265 98.863  288.505 1.00 61.71  ? 64  ASN A N   1 
ATOM 504  C CA  . ASN A 1 64  ? 169.806 98.619  287.186 1.00 62.85  ? 64  ASN A CA  1 
ATOM 505  C C   . ASN A 1 64  ? 170.695 99.787  286.787 1.00 61.96  ? 64  ASN A C   1 
ATOM 506  O O   . ASN A 1 64  ? 171.802 99.569  286.332 1.00 72.01  ? 64  ASN A O   1 
ATOM 507  C CB  . ASN A 1 64  ? 168.718 98.363  286.151 1.00 64.40  ? 64  ASN A CB  1 
ATOM 508  C CG  . ASN A 1 64  ? 168.037 97.033  286.348 1.00 65.90  ? 64  ASN A CG  1 
ATOM 509  O OD1 . ASN A 1 64  ? 168.524 96.159  287.083 1.00 66.59  ? 64  ASN A OD1 1 
ATOM 510  N ND2 . ASN A 1 64  ? 166.899 96.864  285.696 1.00 72.80  ? 64  ASN A ND2 1 
ATOM 511  N N   . PHE A 1 65  ? 170.221 101.018 286.938 1.00 62.55  ? 65  PHE A N   1 
ATOM 512  C CA  . PHE A 1 65  ? 171.013 102.167 286.555 1.00 63.79  ? 65  PHE A CA  1 
ATOM 513  C C   . PHE A 1 65  ? 172.313 102.184 287.341 1.00 62.00  ? 65  PHE A C   1 
ATOM 514  O O   . PHE A 1 65  ? 173.332 102.606 286.822 1.00 71.81  ? 65  PHE A O   1 
ATOM 515  C CB  . PHE A 1 65  ? 170.284 103.481 286.822 1.00 70.03  ? 65  PHE A CB  1 
ATOM 516  C CG  . PHE A 1 65  ? 169.186 103.814 285.834 1.00 74.25  ? 65  PHE A CG  1 
ATOM 517  C CD1 . PHE A 1 65  ? 169.405 103.743 284.470 1.00 82.66  ? 65  PHE A CD1 1 
ATOM 518  C CD2 . PHE A 1 65  ? 167.933 104.187 286.273 1.00 81.39  ? 65  PHE A CD2 1 
ATOM 519  C CE1 . PHE A 1 65  ? 168.404 104.051 283.564 1.00 87.64  ? 65  PHE A CE1 1 
ATOM 520  C CE2 . PHE A 1 65  ? 166.926 104.474 285.363 1.00 88.91  ? 65  PHE A CE2 1 
ATOM 521  C CZ  . PHE A 1 65  ? 167.165 104.416 284.012 1.00 88.90  ? 65  PHE A CZ  1 
ATOM 522  N N   . LEU A 1 66  ? 172.258 101.778 288.598 1.00 60.50  ? 66  LEU A N   1 
ATOM 523  C CA  . LEU A 1 66  ? 173.408 101.859 289.463 1.00 59.92  ? 66  LEU A CA  1 
ATOM 524  C C   . LEU A 1 66  ? 174.424 100.819 289.031 1.00 62.42  ? 66  LEU A C   1 
ATOM 525  O O   . LEU A 1 66  ? 175.619 101.091 289.019 1.00 70.82  ? 66  LEU A O   1 
ATOM 526  C CB  . LEU A 1 66  ? 172.906 101.632 290.879 1.00 64.07  ? 66  LEU A CB  1 
ATOM 527  C CG  . LEU A 1 66  ? 173.935 101.716 291.997 1.00 69.51  ? 66  LEU A CG  1 
ATOM 528  C CD1 . LEU A 1 66  ? 174.297 103.169 292.234 1.00 73.74  ? 66  LEU A CD1 1 
ATOM 529  C CD2 . LEU A 1 66  ? 173.392 101.070 293.253 1.00 76.39  ? 66  LEU A CD2 1 
ATOM 530  N N   . ARG A 1 67  ? 173.955 99.634  288.666 1.00 62.60  ? 67  ARG A N   1 
ATOM 531  C CA  . ARG A 1 67  ? 174.860 98.597  288.211 1.00 67.56  ? 67  ARG A CA  1 
ATOM 532  C C   . ARG A 1 67  ? 175.453 98.990  286.855 1.00 66.13  ? 67  ARG A C   1 
ATOM 533  O O   . ARG A 1 67  ? 176.650 98.843  286.661 1.00 72.63  ? 67  ARG A O   1 
ATOM 534  C CB  . ARG A 1 67  ? 174.161 97.235  288.246 1.00 71.05  ? 67  ARG A CB  1 
ATOM 535  C CG  . ARG A 1 67  ? 174.934 96.115  287.570 1.00 75.55  ? 67  ARG A CG  1 
ATOM 536  C CD  . ARG A 1 67  ? 174.287 94.748  287.694 1.00 83.77  ? 67  ARG A CD  1 
ATOM 537  N NE  . ARG A 1 67  ? 172.837 94.766  287.465 1.00 87.24  ? 67  ARG A NE  1 
ATOM 538  C CZ  . ARG A 1 67  ? 171.937 94.381  288.376 1.00 97.04  ? 67  ARG A CZ  1 
ATOM 539  N NH1 . ARG A 1 67  ? 170.653 94.619  288.153 1.00 101.10 ? 67  ARG A NH1 1 
ATOM 540  N NH2 . ARG A 1 67  ? 172.301 93.788  289.517 1.00 97.54  ? 67  ARG A NH2 1 
ATOM 541  N N   . MET A 1 68  ? 174.674 99.515  285.915 1.00 66.08  ? 68  MET A N   1 
ATOM 542  C CA  . MET A 1 68  ? 175.279 99.913  284.658 1.00 70.64  ? 68  MET A CA  1 
ATOM 543  C C   . MET A 1 68  ? 176.273 101.032 284.916 1.00 65.04  ? 68  MET A C   1 
ATOM 544  O O   . MET A 1 68  ? 177.346 101.033 284.344 1.00 71.63  ? 68  MET A O   1 
ATOM 545  C CB  . MET A 1 68  ? 174.282 100.406 283.603 1.00 83.65  ? 68  MET A CB  1 
ATOM 546  C CG  . MET A 1 68  ? 173.502 99.285  282.944 1.00 96.89  ? 68  MET A CG  1 
ATOM 547  S SD  . MET A 1 68  ? 172.165 99.888  281.890 1.00 113.76 ? 68  MET A SD  1 
ATOM 548  C CE  . MET A 1 68  ? 170.979 98.537  282.075 1.00 116.57 ? 68  MET A CE  1 
ATOM 549  N N   . SER A 1 69  ? 175.936 101.996 285.753 1.00 64.25  ? 69  SER A N   1 
ATOM 550  C CA  . SER A 1 69  ? 176.883 103.053 286.045 1.00 65.82  ? 69  SER A CA  1 
ATOM 551  C C   . SER A 1 69  ? 178.220 102.451 286.485 1.00 66.20  ? 69  SER A C   1 
ATOM 552  O O   . SER A 1 69  ? 179.280 102.906 286.060 1.00 69.55  ? 69  SER A O   1 
ATOM 553  C CB  . SER A 1 69  ? 176.344 103.997 287.076 1.00 66.05  ? 69  SER A CB  1 
ATOM 554  O OG  . SER A 1 69  ? 177.307 104.985 287.404 1.00 70.57  ? 69  SER A OG  1 
ATOM 555  N N   . ALA A 1 70  ? 178.177 101.429 287.332 1.00 61.16  ? 70  ALA A N   1 
ATOM 556  C CA  . ALA A 1 70  ? 179.397 100.824 287.829 1.00 58.56  ? 70  ALA A CA  1 
ATOM 557  C C   . ALA A 1 70  ? 180.197 100.222 286.690 1.00 60.42  ? 70  ALA A C   1 
ATOM 558  O O   . ALA A 1 70  ? 181.415 100.285 286.717 1.00 68.65  ? 70  ALA A O   1 
ATOM 559  C CB  . ALA A 1 70  ? 179.073 99.766  288.841 1.00 66.06  ? 70  ALA A CB  1 
ATOM 560  N N   . ARG A 1 71  ? 179.522 99.587  285.728 1.00 64.61  ? 71  ARG A N   1 
ATOM 561  C CA  . ARG A 1 71  ? 180.208 98.931  284.628 1.00 59.37  ? 71  ARG A CA  1 
ATOM 562  C C   . ARG A 1 71  ? 180.828 99.980  283.718 1.00 49.56  ? 71  ARG A C   1 
ATOM 563  O O   . ARG A 1 71  ? 181.989 99.879  283.389 1.00 57.23  ? 71  ARG A O   1 
ATOM 564  C CB  . ARG A 1 71  ? 179.289 98.004  283.831 1.00 61.81  ? 71  ARG A CB  1 
ATOM 565  C CG  . ARG A 1 71  ? 178.808 96.788  284.602 1.00 63.27  ? 71  ARG A CG  1 
ATOM 566  C CD  . ARG A 1 71  ? 179.935 95.892  284.992 1.00 70.75  ? 71  ARG A CD  1 
ATOM 567  N NE  . ARG A 1 71  ? 179.393 94.627  285.484 1.00 78.18  ? 71  ARG A NE  1 
ATOM 568  C CZ  . ARG A 1 71  ? 179.089 94.381  286.751 1.00 89.05  ? 71  ARG A CZ  1 
ATOM 569  N NH1 . ARG A 1 71  ? 178.835 93.132  287.115 1.00 92.84  ? 71  ARG A NH1 1 
ATOM 570  N NH2 . ARG A 1 71  ? 179.095 95.353  287.662 1.00 92.06  ? 71  ARG A NH2 1 
ATOM 571  N N   . VAL A 1 72  ? 180.084 101.003 283.349 1.00 50.41  ? 72  VAL A N   1 
ATOM 572  C CA  . VAL A 1 72  ? 180.629 102.034 282.492 1.00 55.92  ? 72  VAL A CA  1 
ATOM 573  C C   . VAL A 1 72  ? 181.798 102.720 283.188 1.00 62.36  ? 72  VAL A C   1 
ATOM 574  O O   . VAL A 1 72  ? 182.772 103.029 282.525 1.00 69.04  ? 72  VAL A O   1 
ATOM 575  C CB  . VAL A 1 72  ? 179.554 103.043 282.059 1.00 60.69  ? 72  VAL A CB  1 
ATOM 576  C CG1 . VAL A 1 72  ? 180.099 104.212 281.251 1.00 58.42  ? 72  VAL A CG1 1 
ATOM 577  C CG2 . VAL A 1 72  ? 178.462 102.343 281.262 1.00 65.17  ? 72  VAL A CG2 1 
ATOM 578  N N   . ASP A 1 73  ? 181.736 102.958 284.498 1.00 66.59  ? 73  ASP A N   1 
ATOM 579  C CA  . ASP A 1 73  ? 182.889 103.510 285.183 1.00 69.55  ? 73  ASP A CA  1 
ATOM 580  C C   . ASP A 1 73  ? 184.095 102.591 285.030 1.00 65.37  ? 73  ASP A C   1 
ATOM 581  O O   . ASP A 1 73  ? 185.192 103.090 284.711 1.00 70.05  ? 73  ASP A O   1 
ATOM 582  C CB  . ASP A 1 73  ? 182.614 103.806 286.648 1.00 85.83  ? 73  ASP A CB  1 
ATOM 583  C CG  . ASP A 1 73  ? 182.479 105.289 286.977 1.00 109.05 ? 73  ASP A CG  1 
ATOM 584  O OD1 . ASP A 1 73  ? 183.109 106.125 286.242 1.00 108.31 ? 73  ASP A OD1 1 
ATOM 585  O OD2 . ASP A 1 73  ? 181.714 105.609 287.949 1.00 118.30 ? 73  ASP A OD2 1 
ATOM 586  N N   . ALA A 1 74  ? 183.925 101.280 285.257 1.00 56.09  ? 74  ALA A N   1 
ATOM 587  C CA  . ALA A 1 74  ? 185.085 100.411 285.231 1.00 59.64  ? 74  ALA A CA  1 
ATOM 588  C C   . ALA A 1 74  ? 185.757 100.510 283.863 1.00 62.46  ? 74  ALA A C   1 
ATOM 589  O O   . ALA A 1 74  ? 186.995 100.629 283.789 1.00 64.74  ? 74  ALA A O   1 
ATOM 590  C CB  . ALA A 1 74  ? 184.727 98.987  285.579 1.00 64.04  ? 74  ALA A CB  1 
ATOM 591  N N   . VAL A 1 75  ? 184.950 100.516 282.797 1.00 59.80  ? 75  VAL A N   1 
ATOM 592  C CA  . VAL A 1 75  ? 185.484 100.695 281.464 1.00 55.38  ? 75  VAL A CA  1 
ATOM 593  C C   . VAL A 1 75  ? 186.237 102.016 281.398 1.00 56.32  ? 75  VAL A C   1 
ATOM 594  O O   . VAL A 1 75  ? 187.375 102.053 280.965 1.00 61.68  ? 75  VAL A O   1 
ATOM 595  C CB  . VAL A 1 75  ? 184.363 100.624 280.421 1.00 57.95  ? 75  VAL A CB  1 
ATOM 596  C CG1 . VAL A 1 75  ? 184.723 101.290 279.096 1.00 62.32  ? 75  VAL A CG1 1 
ATOM 597  C CG2 . VAL A 1 75  ? 183.965 99.175  280.216 1.00 64.33  ? 75  VAL A CG2 1 
ATOM 598  N N   . ALA A 1 76  ? 185.619 103.099 281.830 1.00 56.61  ? 76  ALA A N   1 
ATOM 599  C CA  . ALA A 1 76  ? 186.256 104.388 281.699 1.00 58.40  ? 76  ALA A CA  1 
ATOM 600  C C   . ALA A 1 76  ? 187.582 104.372 282.454 1.00 57.11  ? 76  ALA A C   1 
ATOM 601  O O   . ALA A 1 76  ? 188.541 104.989 282.026 1.00 62.50  ? 76  ALA A O   1 
ATOM 602  C CB  . ALA A 1 76  ? 185.321 105.461 282.200 1.00 65.61  ? 76  ALA A CB  1 
ATOM 603  N N   . ALA A 1 77  ? 187.656 103.656 283.566 1.00 59.67  ? 77  ALA A N   1 
ATOM 604  C CA  . ALA A 1 77  ? 188.887 103.637 284.337 1.00 65.57  ? 77  ALA A CA  1 
ATOM 605  C C   . ALA A 1 77  ? 189.988 102.971 283.535 1.00 63.32  ? 77  ALA A C   1 
ATOM 606  O O   . ALA A 1 77  ? 191.168 103.242 283.739 1.00 63.83  ? 77  ALA A O   1 
ATOM 607  C CB  . ALA A 1 77  ? 188.687 102.902 285.643 1.00 72.90  ? 77  ALA A CB  1 
ATOM 608  N N   . ARG A 1 78  ? 189.589 102.073 282.640 1.00 65.75  ? 78  ARG A N   1 
ATOM 609  C CA  . ARG A 1 78  ? 190.566 101.283 281.917 1.00 64.83  ? 78  ARG A CA  1 
ATOM 610  C C   . ARG A 1 78  ? 190.972 101.996 280.631 1.00 60.64  ? 78  ARG A C   1 
ATOM 611  O O   . ARG A 1 78  ? 192.123 101.938 280.232 1.00 69.32  ? 78  ARG A O   1 
ATOM 612  C CB  . ARG A 1 78  ? 190.015 99.883  281.678 1.00 61.69  ? 78  ARG A CB  1 
ATOM 613  C CG  . ARG A 1 78  ? 191.121 98.877  281.908 1.00 68.73  ? 78  ARG A CG  1 
ATOM 614  C CD  . ARG A 1 78  ? 190.519 97.542  281.748 1.00 77.25  ? 78  ARG A CD  1 
ATOM 615  N NE  . ARG A 1 78  ? 191.580 96.544  281.603 1.00 87.59  ? 78  ARG A NE  1 
ATOM 616  C CZ  . ARG A 1 78  ? 192.258 95.980  282.593 1.00 96.57  ? 78  ARG A CZ  1 
ATOM 617  N NH1 . ARG A 1 78  ? 192.998 94.912  282.328 1.00 101.59 ? 78  ARG A NH1 1 
ATOM 618  N NH2 . ARG A 1 78  ? 192.123 96.398  283.848 1.00 98.15  ? 78  ARG A NH2 1 
ATOM 619  N N   . VAL A 1 79  ? 190.052 102.707 280.005 1.00 55.64  ? 79  VAL A N   1 
ATOM 620  C CA  . VAL A 1 79  ? 190.408 103.580 278.912 1.00 49.30  ? 79  VAL A CA  1 
ATOM 621  C C   . VAL A 1 79  ? 191.285 104.699 279.436 1.00 56.59  ? 79  VAL A C   1 
ATOM 622  O O   . VAL A 1 79  ? 192.121 105.192 278.696 1.00 65.36  ? 79  VAL A O   1 
ATOM 623  C CB  . VAL A 1 79  ? 189.159 104.145 278.226 1.00 56.05  ? 79  VAL A CB  1 
ATOM 624  C CG1 . VAL A 1 79  ? 189.467 105.270 277.254 1.00 57.38  ? 79  VAL A CG1 1 
ATOM 625  C CG2 . VAL A 1 79  ? 188.386 103.048 277.505 1.00 60.67  ? 79  VAL A CG2 1 
ATOM 626  N N   . GLN A 1 80  ? 191.115 105.122 280.689 1.00 62.89  ? 80  GLN A N   1 
ATOM 627  C CA  . GLN A 1 80  ? 191.993 106.145 281.236 1.00 64.19  ? 80  GLN A CA  1 
ATOM 628  C C   . GLN A 1 80  ? 193.422 105.612 281.232 1.00 63.91  ? 80  GLN A C   1 
ATOM 629  O O   . GLN A 1 80  ? 194.342 106.348 280.853 1.00 73.39  ? 80  GLN A O   1 
ATOM 630  C CB  . GLN A 1 80  ? 191.587 106.548 282.651 1.00 71.28  ? 80  GLN A CB  1 
ATOM 631  C CG  . GLN A 1 80  ? 192.484 107.582 283.315 1.00 73.38  ? 80  GLN A CG  1 
ATOM 632  C CD  . GLN A 1 80  ? 192.434 108.921 282.610 1.00 79.10  ? 80  GLN A CD  1 
ATOM 633  O OE1 . GLN A 1 80  ? 191.510 109.723 282.809 1.00 82.31  ? 80  GLN A OE1 1 
ATOM 634  N NE2 . GLN A 1 80  ? 193.447 109.197 281.799 1.00 78.49  ? 80  GLN A NE2 1 
ATOM 635  N N   . THR A 1 81  ? 193.610 104.345 281.622 1.00 60.40  ? 81  THR A N   1 
ATOM 636  C CA  . THR A 1 81  ? 194.946 103.783 281.685 1.00 64.01  ? 81  THR A CA  1 
ATOM 637  C C   . THR A 1 81  ? 195.573 103.833 280.298 1.00 59.04  ? 81  THR A C   1 
ATOM 638  O O   . THR A 1 81  ? 196.734 104.189 280.160 1.00 63.72  ? 81  THR A O   1 
ATOM 639  C CB  . THR A 1 81  ? 194.890 102.362 282.252 1.00 72.91  ? 81  THR A CB  1 
ATOM 640  O OG1 . THR A 1 81  ? 194.606 102.557 283.637 1.00 74.10  ? 81  THR A OG1 1 
ATOM 641  C CG2 . THR A 1 81  ? 196.204 101.604 282.150 1.00 76.44  ? 81  THR A CG2 1 
ATOM 642  N N   . ALA A 1 82  ? 194.803 103.472 279.275 1.00 57.54  ? 82  ALA A N   1 
ATOM 643  C CA  . ALA A 1 82  ? 195.297 103.464 277.910 1.00 53.71  ? 82  ALA A CA  1 
ATOM 644  C C   . ALA A 1 82  ? 195.688 104.857 277.466 1.00 52.86  ? 82  ALA A C   1 
ATOM 645  O O   . ALA A 1 82  ? 196.612 104.997 276.688 1.00 62.28  ? 82  ALA A O   1 
ATOM 646  C CB  . ALA A 1 82  ? 194.263 102.924 276.970 1.00 54.85  ? 82  ALA A CB  1 
ATOM 647  N N   . VAL A 1 83  ? 194.957 105.873 277.897 1.00 57.15  ? 83  VAL A N   1 
ATOM 648  C CA  . VAL A 1 83  ? 195.254 107.218 277.452 1.00 54.42  ? 83  VAL A CA  1 
ATOM 649  C C   . VAL A 1 83  ? 196.576 107.641 278.060 1.00 55.73  ? 83  VAL A C   1 
ATOM 650  O O   . VAL A 1 83  ? 197.405 108.189 277.350 1.00 60.08  ? 83  VAL A O   1 
ATOM 651  C CB  . VAL A 1 83  ? 194.139 108.212 277.795 1.00 59.94  ? 83  VAL A CB  1 
ATOM 652  C CG1 . VAL A 1 83  ? 194.602 109.663 277.756 1.00 65.93  ? 83  VAL A CG1 1 
ATOM 653  C CG2 . VAL A 1 83  ? 192.950 108.019 276.869 1.00 63.22  ? 83  VAL A CG2 1 
ATOM 654  N N   . THR A 1 84  ? 196.736 107.378 279.360 1.00 59.11  ? 84  THR A N   1 
ATOM 655  C CA  . THR A 1 84  ? 197.935 107.763 280.123 1.00 60.43  ? 84  THR A CA  1 
ATOM 656  C C   . THR A 1 84  ? 199.142 107.016 279.622 1.00 59.16  ? 84  THR A C   1 
ATOM 657  O O   . THR A 1 84  ? 200.165 107.677 279.442 1.00 65.50  ? 84  THR A O   1 
ATOM 658  C CB  . THR A 1 84  ? 197.685 107.454 281.598 1.00 67.86  ? 84  THR A CB  1 
ATOM 659  O OG1 . THR A 1 84  ? 196.565 108.253 281.963 1.00 63.38  ? 84  THR A OG1 1 
ATOM 660  C CG2 . THR A 1 84  ? 198.887 107.779 282.466 1.00 73.00  ? 84  THR A CG2 1 
ATOM 661  N N   . MET A 1 85  ? 199.054 105.691 279.465 1.00 62.19  ? 85  MET A N   1 
ATOM 662  C CA  . MET A 1 85  ? 200.223 104.909 279.095 1.00 67.15  ? 85  MET A CA  1 
ATOM 663  C C   . MET A 1 85  ? 200.502 105.071 277.616 1.00 62.88  ? 85  MET A C   1 
ATOM 664  O O   . MET A 1 85  ? 201.585 104.730 277.175 1.00 73.37  ? 85  MET A O   1 
ATOM 665  C CB  . MET A 1 85  ? 200.087 103.422 279.433 1.00 76.07  ? 85  MET A CB  1 
ATOM 666  C CG  . MET A 1 85  ? 199.967 103.208 280.939 1.00 88.38  ? 85  MET A CG  1 
ATOM 667  S SD  . MET A 1 85  ? 201.177 104.108 281.942 1.00 98.26  ? 85  MET A SD  1 
ATOM 668  C CE  . MET A 1 85  ? 202.600 103.057 281.579 1.00 100.39 ? 85  MET A CE  1 
ATOM 669  N N   . GLY A 1 86  ? 199.557 105.603 276.857 1.00 61.70  ? 86  GLY A N   1 
ATOM 670  C CA  . GLY A 1 86  ? 199.876 106.052 275.514 1.00 65.88  ? 86  GLY A CA  1 
ATOM 671  C C   . GLY A 1 86  ? 200.852 107.220 275.564 1.00 63.65  ? 86  GLY A C   1 
ATOM 672  O O   . GLY A 1 86  ? 201.906 107.168 274.958 1.00 68.58  ? 86  GLY A O   1 
ATOM 673  N N   . LYS A 1 87  ? 200.486 108.252 276.316 1.00 63.57  ? 87  LYS A N   1 
ATOM 674  C CA  . LYS A 1 87  ? 201.279 109.452 276.444 1.00 61.45  ? 87  LYS A CA  1 
ATOM 675  C C   . LYS A 1 87  ? 202.658 109.095 276.985 1.00 60.74  ? 87  LYS A C   1 
ATOM 676  O O   . LYS A 1 87  ? 203.655 109.640 276.515 1.00 67.41  ? 87  LYS A O   1 
ATOM 677  C CB  . LYS A 1 87  ? 200.519 110.453 277.320 1.00 66.82  ? 87  LYS A CB  1 
ATOM 678  C CG  . LYS A 1 87  ? 199.300 111.059 276.636 1.00 72.10  ? 87  LYS A CG  1 
ATOM 679  C CD  . LYS A 1 87  ? 198.603 112.098 277.497 1.00 81.55  ? 87  LYS A CD  1 
ATOM 680  C CE  . LYS A 1 87  ? 197.419 112.714 276.808 1.00 90.81  ? 87  LYS A CE  1 
ATOM 681  N NZ  . LYS A 1 87  ? 196.607 113.488 277.761 1.00 96.62  ? 87  LYS A NZ  1 
ATOM 682  N N   . VAL A 1 88  ? 202.725 108.194 277.959 1.00 56.27  ? 88  VAL A N   1 
ATOM 683  C CA  . VAL A 1 88  ? 203.998 107.863 278.564 1.00 55.05  ? 88  VAL A CA  1 
ATOM 684  C C   . VAL A 1 88  ? 204.860 107.172 277.520 1.00 55.28  ? 88  VAL A C   1 
ATOM 685  O O   . VAL A 1 88  ? 206.062 107.408 277.476 1.00 60.33  ? 88  VAL A O   1 
ATOM 686  C CB  . VAL A 1 88  ? 203.850 106.992 279.823 1.00 56.90  ? 88  VAL A CB  1 
ATOM 687  C CG1 . VAL A 1 88  ? 205.169 106.350 280.239 1.00 58.88  ? 88  VAL A CG1 1 
ATOM 688  C CG2 . VAL A 1 88  ? 203.249 107.775 280.976 1.00 58.96  ? 88  VAL A CG2 1 
ATOM 689  N N   . THR A 1 89  ? 204.267 106.280 276.729 1.00 56.89  ? 89  THR A N   1 
ATOM 690  C CA  . THR A 1 89  ? 205.031 105.512 275.760 1.00 58.22  ? 89  THR A CA  1 
ATOM 691  C C   . THR A 1 89  ? 205.550 106.438 274.666 1.00 51.24  ? 89  THR A C   1 
ATOM 692  O O   . THR A 1 89  ? 206.664 106.280 274.212 1.00 51.90  ? 89  THR A O   1 
ATOM 693  C CB  . THR A 1 89  ? 204.181 104.370 275.200 1.00 62.39  ? 89  THR A CB  1 
ATOM 694  O OG1 . THR A 1 89  ? 204.064 103.469 276.297 1.00 61.54  ? 89  THR A OG1 1 
ATOM 695  C CG2 . THR A 1 89  ? 204.846 103.600 274.075 1.00 67.54  ? 89  THR A CG2 1 
ATOM 696  N N   . LYS A 1 90  ? 204.754 107.402 274.239 1.00 58.35  ? 90  LYS A N   1 
ATOM 697  C CA  . LYS A 1 90  ? 205.207 108.331 273.225 1.00 64.58  ? 90  LYS A CA  1 
ATOM 698  C C   . LYS A 1 90  ? 206.286 109.252 273.770 1.00 65.74  ? 90  LYS A C   1 
ATOM 699  O O   . LYS A 1 90  ? 207.197 109.600 273.032 1.00 72.07  ? 90  LYS A O   1 
ATOM 700  C CB  . LYS A 1 90  ? 204.115 109.245 272.667 1.00 73.75  ? 90  LYS A CB  1 
ATOM 701  C CG  . LYS A 1 90  ? 203.269 108.529 271.637 1.00 83.51  ? 90  LYS A CG  1 
ATOM 702  C CD  . LYS A 1 90  ? 202.465 109.440 270.714 1.00 92.74  ? 90  LYS A CD  1 
ATOM 703  C CE  . LYS A 1 90  ? 202.018 108.665 269.488 1.00 99.59  ? 90  LYS A CE  1 
ATOM 704  N NZ  . LYS A 1 90  ? 201.216 109.460 268.544 1.00 101.99 ? 90  LYS A NZ  1 
ATOM 705  N N   . SER A 1 91  ? 206.182 109.672 275.028 1.00 62.79  ? 91  SER A N   1 
ATOM 706  C CA  . SER A 1 91  ? 207.245 110.481 275.591 1.00 58.36  ? 91  SER A CA  1 
ATOM 707  C C   . SER A 1 91  ? 208.522 109.673 275.658 1.00 52.16  ? 91  SER A C   1 
ATOM 708  O O   . SER A 1 91  ? 209.565 110.194 275.323 1.00 60.28  ? 91  SER A O   1 
ATOM 709  C CB  . SER A 1 91  ? 206.892 111.030 276.926 1.00 68.24  ? 91  SER A CB  1 
ATOM 710  O OG  . SER A 1 91  ? 205.971 112.103 276.744 1.00 77.29  ? 91  SER A OG  1 
ATOM 711  N N   . MET A 1 92  ? 208.453 108.411 276.057 1.00 56.70  ? 92  MET A N   1 
ATOM 712  C CA  . MET A 1 92  ? 209.672 107.632 276.189 1.00 59.80  ? 92  MET A CA  1 
ATOM 713  C C   . MET A 1 92  ? 210.242 107.278 274.824 1.00 58.21  ? 92  MET A C   1 
ATOM 714  O O   . MET A 1 92  ? 211.446 107.078 274.703 1.00 63.02  ? 92  MET A O   1 
ATOM 715  C CB  . MET A 1 92  ? 209.453 106.333 276.961 1.00 61.58  ? 92  MET A CB  1 
ATOM 716  C CG  . MET A 1 92  ? 209.370 106.547 278.433 1.00 65.73  ? 92  MET A CG  1 
ATOM 717  S SD  . MET A 1 92  ? 208.973 104.961 279.181 1.00 82.76  ? 92  MET A SD  1 
ATOM 718  C CE  . MET A 1 92  ? 210.436 103.924 279.030 1.00 79.29  ? 92  MET A CE  1 
ATOM 719  N N   . ALA A 1 93  ? 209.404 107.178 273.798 1.00 59.98  ? 93  ALA A N   1 
ATOM 720  C CA  . ALA A 1 93  ? 209.937 106.963 272.463 1.00 63.08  ? 93  ALA A CA  1 
ATOM 721  C C   . ALA A 1 93  ? 210.651 108.216 271.985 1.00 65.19  ? 93  ALA A C   1 
ATOM 722  O O   . ALA A 1 93  ? 211.605 108.132 271.225 1.00 75.43  ? 93  ALA A O   1 
ATOM 723  C CB  . ALA A 1 93  ? 208.856 106.604 271.490 1.00 66.00  ? 93  ALA A CB  1 
ATOM 724  N N   . GLY A 1 94  ? 210.170 109.372 272.417 1.00 61.83  ? 94  GLY A N   1 
ATOM 725  C CA  . GLY A 1 94  ? 210.796 110.618 272.049 1.00 58.74  ? 94  GLY A CA  1 
ATOM 726  C C   . GLY A 1 94  ? 212.148 110.720 272.726 1.00 57.14  ? 94  GLY A C   1 
ATOM 727  O O   . GLY A 1 94  ? 213.137 111.068 272.092 1.00 76.25  ? 94  GLY A O   1 
ATOM 728  N N   . VAL A 1 95  ? 212.189 110.407 274.003 1.00 51.86  ? 95  VAL A N   1 
ATOM 729  C CA  . VAL A 1 95  ? 213.425 110.481 274.743 1.00 51.89  ? 95  VAL A CA  1 
ATOM 730  C C   . VAL A 1 95  ? 214.447 109.583 274.068 1.00 56.23  ? 95  VAL A C   1 
ATOM 731  O O   . VAL A 1 95  ? 215.595 109.973 273.912 1.00 65.21  ? 95  VAL A O   1 
ATOM 732  C CB  . VAL A 1 95  ? 213.141 110.093 276.201 1.00 55.71  ? 95  VAL A CB  1 
ATOM 733  C CG1 . VAL A 1 95  ? 214.361 109.564 276.939 1.00 55.74  ? 95  VAL A CG1 1 
ATOM 734  C CG2 . VAL A 1 95  ? 212.501 111.265 276.935 1.00 60.08  ? 95  VAL A CG2 1 
ATOM 735  N N   . VAL A 1 96  ? 214.037 108.401 273.631 1.00 58.53  ? 96  VAL A N   1 
ATOM 736  C CA  . VAL A 1 96  ? 214.995 107.429 273.153 1.00 57.35  ? 96  VAL A CA  1 
ATOM 737  C C   . VAL A 1 96  ? 215.627 107.973 271.889 1.00 57.96  ? 96  VAL A C   1 
ATOM 738  O O   . VAL A 1 96  ? 216.809 107.720 271.685 1.00 65.82  ? 96  VAL A O   1 
ATOM 739  C CB  . VAL A 1 96  ? 214.365 106.041 272.941 1.00 57.93  ? 96  VAL A CB  1 
ATOM 740  C CG1 . VAL A 1 96  ? 215.179 105.148 272.015 1.00 62.65  ? 96  VAL A CG1 1 
ATOM 741  C CG2 . VAL A 1 96  ? 214.165 105.329 274.266 1.00 58.84  ? 96  VAL A CG2 1 
ATOM 742  N N   . LYS A 1 97  ? 214.866 108.692 271.058 1.00 57.27  ? 97  LYS A N   1 
ATOM 743  C CA  . LYS A 1 97  ? 215.431 109.129 269.795 1.00 65.63  ? 97  LYS A CA  1 
ATOM 744  C C   . LYS A 1 97  ? 216.246 110.403 269.983 1.00 64.26  ? 97  LYS A C   1 
ATOM 745  O O   . LYS A 1 97  ? 217.239 110.591 269.295 1.00 69.51  ? 97  LYS A O   1 
ATOM 746  C CB  . LYS A 1 97  ? 214.421 109.312 268.665 1.00 69.80  ? 97  LYS A CB  1 
ATOM 747  C CG  . LYS A 1 97  ? 213.658 110.602 268.724 1.00 78.86  ? 97  LYS A CG  1 
ATOM 748  C CD  . LYS A 1 97  ? 212.772 110.793 267.499 1.00 88.43  ? 97  LYS A CD  1 
ATOM 749  C CE  . LYS A 1 97  ? 213.489 111.330 266.295 1.00 90.21  ? 97  LYS A CE  1 
ATOM 750  N NZ  . LYS A 1 97  ? 212.549 111.662 265.219 1.00 92.91  ? 97  LYS A NZ  1 
ATOM 751  N N   . SER A 1 98  ? 215.862 111.274 270.904 1.00 64.45  ? 98  SER A N   1 
ATOM 752  C CA  . SER A 1 98  ? 216.665 112.466 271.096 1.00 64.19  ? 98  SER A CA  1 
ATOM 753  C C   . SER A 1 98  ? 217.960 112.107 271.808 1.00 59.72  ? 98  SER A C   1 
ATOM 754  O O   . SER A 1 98  ? 218.950 112.795 271.641 1.00 69.85  ? 98  SER A O   1 
ATOM 755  C CB  . SER A 1 98  ? 215.928 113.533 271.834 1.00 66.85  ? 98  SER A CB  1 
ATOM 756  O OG  . SER A 1 98  ? 215.830 113.173 273.206 1.00 69.53  ? 98  SER A OG  1 
ATOM 757  N N   . MET A 1 99  ? 217.972 111.057 272.611 1.00 59.27  ? 99  MET A N   1 
ATOM 758  C CA  . MET A 1 99  ? 219.225 110.684 273.238 1.00 63.11  ? 99  MET A CA  1 
ATOM 759  C C   . MET A 1 99  ? 220.084 109.944 272.219 1.00 62.66  ? 99  MET A C   1 
ATOM 760  O O   . MET A 1 99  ? 221.303 109.965 272.313 1.00 70.17  ? 99  MET A O   1 
ATOM 761  C CB  . MET A 1 99  ? 219.012 109.831 274.494 1.00 67.49  ? 99  MET A CB  1 
ATOM 762  C CG  . MET A 1 99  ? 218.567 110.648 275.691 1.00 70.92  ? 99  MET A CG  1 
ATOM 763  S SD  . MET A 1 99  ? 218.545 109.720 277.239 1.00 82.19  ? 99  MET A SD  1 
ATOM 764  C CE  . MET A 1 99  ? 220.278 109.271 277.386 1.00 78.12  ? 99  MET A CE  1 
ATOM 765  N N   . ASP A 1 100 ? 219.460 109.277 271.256 1.00 67.07  ? 100 ASP A N   1 
ATOM 766  C CA  . ASP A 1 100 ? 220.197 108.529 270.259 1.00 75.58  ? 100 ASP A CA  1 
ATOM 767  C C   . ASP A 1 100 ? 220.993 109.466 269.365 1.00 69.25  ? 100 ASP A C   1 
ATOM 768  O O   . ASP A 1 100 ? 222.089 109.114 268.906 1.00 69.96  ? 100 ASP A O   1 
ATOM 769  C CB  . ASP A 1 100 ? 219.272 107.741 269.344 1.00 86.40  ? 100 ASP A CB  1 
ATOM 770  C CG  . ASP A 1 100 ? 219.986 106.858 268.325 1.00 100.14 ? 100 ASP A CG  1 
ATOM 771  O OD1 . ASP A 1 100 ? 220.886 106.062 268.745 1.00 101.74 ? 100 ASP A OD1 1 
ATOM 772  O OD2 . ASP A 1 100 ? 219.647 106.976 267.118 1.00 105.40 ? 100 ASP A OD2 1 
ATOM 773  N N   . ALA A 1 101 ? 220.396 110.618 269.077 1.00 64.74  ? 101 ALA A N   1 
ATOM 774  C CA  . ALA A 1 101 ? 221.034 111.636 268.271 1.00 63.38  ? 101 ALA A CA  1 
ATOM 775  C C   . ALA A 1 101 ? 222.235 112.206 269.014 1.00 64.18  ? 101 ALA A C   1 
ATOM 776  O O   . ALA A 1 101 ? 223.334 112.219 268.469 1.00 74.52  ? 101 ALA A O   1 
ATOM 777  C CB  . ALA A 1 101 ? 220.045 112.713 267.948 1.00 67.72  ? 101 ALA A CB  1 
ATOM 778  N N   . THR A 1 102 ? 222.013 112.634 270.260 1.00 57.25  ? 102 THR A N   1 
ATOM 779  C CA  . THR A 1 102 ? 223.047 113.272 271.097 1.00 59.56  ? 102 THR A CA  1 
ATOM 780  C C   . THR A 1 102 ? 224.182 112.321 271.382 1.00 57.59  ? 102 THR A C   1 
ATOM 781  O O   . THR A 1 102 ? 225.306 112.822 271.574 1.00 68.84  ? 102 THR A O   1 
ATOM 782  C CB  . THR A 1 102 ? 222.383 113.726 272.395 1.00 67.50  ? 102 THR A CB  1 
ATOM 783  O OG1 . THR A 1 102 ? 221.487 114.764 272.013 1.00 70.09  ? 102 THR A OG1 1 
ATOM 784  C CG2 . THR A 1 102 ? 223.389 114.236 273.409 1.00 75.07  ? 102 THR A CG2 1 
ATOM 785  N N   . LEU A 1 103 ? 223.926 111.011 271.450 1.00 57.08  ? 103 LEU A N   1 
ATOM 786  C CA  . LEU A 1 103 ? 224.988 110.103 271.834 1.00 64.82  ? 103 LEU A CA  1 
ATOM 787  C C   . LEU A 1 103 ? 225.795 109.778 270.592 1.00 70.46  ? 103 LEU A C   1 
ATOM 788  O O   . LEU A 1 103 ? 226.875 109.203 270.709 1.00 76.43  ? 103 LEU A O   1 
ATOM 789  C CB  . LEU A 1 103 ? 224.484 108.824 272.498 1.00 70.54  ? 103 LEU A CB  1 
ATOM 790  C CG  . LEU A 1 103 ? 223.864 108.979 273.890 1.00 76.22  ? 103 LEU A CG  1 
ATOM 791  C CD1 . LEU A 1 103 ? 222.798 107.914 274.092 1.00 78.90  ? 103 LEU A CD1 1 
ATOM 792  C CD2 . LEU A 1 103 ? 224.913 108.898 274.990 1.00 81.34  ? 103 LEU A CD2 1 
ATOM 793  N N   . LYS A 1 104 ? 225.249 110.097 269.413 1.00 73.80  ? 104 LYS A N   1 
ATOM 794  C CA  . LYS A 1 104 ? 226.015 109.989 268.180 1.00 75.51  ? 104 LYS A CA  1 
ATOM 795  C C   . LYS A 1 104 ? 226.948 111.188 268.078 1.00 70.00  ? 104 LYS A C   1 
ATOM 796  O O   . LYS A 1 104 ? 228.150 111.009 267.957 1.00 78.29  ? 104 LYS A O   1 
ATOM 797  C CB  . LYS A 1 104 ? 225.166 109.897 266.906 1.00 81.85  ? 104 LYS A CB  1 
ATOM 798  C CG  . LYS A 1 104 ? 224.725 108.495 266.507 1.00 89.82  ? 104 LYS A CG  1 
ATOM 799  C CD  . LYS A 1 104 ? 223.619 108.520 265.453 1.00 97.77  ? 104 LYS A CD  1 
ATOM 800  C CE  . LYS A 1 104 ? 223.083 107.153 265.041 1.00 105.41 ? 104 LYS A CE  1 
ATOM 801  N NZ  . LYS A 1 104 ? 222.214 106.456 266.011 1.00 104.66 ? 104 LYS A NZ  1 
ATOM 802  N N   . THR A 1 105 ? 226.414 112.401 268.173 1.00 61.88  ? 105 THR A N   1 
ATOM 803  C CA  . THR A 1 105 ? 227.228 113.572 267.915 1.00 64.83  ? 105 THR A CA  1 
ATOM 804  C C   . THR A 1 105 ? 228.144 113.904 269.093 1.00 68.35  ? 105 THR A C   1 
ATOM 805  O O   . THR A 1 105 ? 228.952 114.828 268.992 1.00 71.41  ? 105 THR A O   1 
ATOM 806  C CB  . THR A 1 105 ? 226.348 114.773 267.594 1.00 72.90  ? 105 THR A CB  1 
ATOM 807  O OG1 . THR A 1 105 ? 225.690 115.181 268.794 1.00 77.83  ? 105 THR A OG1 1 
ATOM 808  C CG2 . THR A 1 105 ? 225.334 114.453 266.516 1.00 78.55  ? 105 THR A CG2 1 
ATOM 809  N N   . MET A 1 106 ? 227.981 113.229 270.230 1.00 70.64  ? 106 MET A N   1 
ATOM 810  C CA  . MET A 1 106 ? 228.925 113.371 271.321 1.00 71.39  ? 106 MET A CA  1 
ATOM 811  C C   . MET A 1 106 ? 229.226 112.005 271.901 1.00 69.43  ? 106 MET A C   1 
ATOM 812  O O   . MET A 1 106 ? 228.786 111.712 273.007 1.00 86.62  ? 106 MET A O   1 
ATOM 813  C CB  . MET A 1 106 ? 228.351 114.268 272.423 1.00 76.70  ? 106 MET A CB  1 
ATOM 814  C CG  . MET A 1 106 ? 228.937 115.647 272.409 1.00 85.99  ? 106 MET A CG  1 
ATOM 815  S SD  . MET A 1 106 ? 230.679 115.595 272.894 1.00 88.95  ? 106 MET A SD  1 
ATOM 816  C CE  . MET A 1 106 ? 230.935 117.362 272.653 1.00 93.65  ? 106 MET A CE  1 
ATOM 817  N N   . ASN A 1 107 ? 229.955 111.169 271.178 1.00 56.15  ? 107 ASN A N   1 
ATOM 818  C CA  . ASN A 1 107 ? 230.088 109.815 271.666 1.00 58.73  ? 107 ASN A CA  1 
ATOM 819  C C   . ASN A 1 107 ? 231.104 109.794 272.799 1.00 52.79  ? 107 ASN A C   1 
ATOM 820  O O   . ASN A 1 107 ? 231.686 110.801 273.122 1.00 57.72  ? 107 ASN A O   1 
ATOM 821  C CB  . ASN A 1 107 ? 230.347 108.841 270.533 1.00 65.63  ? 107 ASN A CB  1 
ATOM 822  C CG  . ASN A 1 107 ? 231.560 109.213 269.737 1.00 66.44  ? 107 ASN A CG  1 
ATOM 823  O OD1 . ASN A 1 107 ? 232.691 108.911 270.166 1.00 77.40  ? 107 ASN A OD1 1 
ATOM 824  N ND2 . ASN A 1 107 ? 231.350 109.802 268.568 1.00 68.92  ? 107 ASN A ND2 1 
ATOM 825  N N   . LEU A 1 108 ? 231.277 108.645 273.427 1.00 57.23  ? 108 LEU A N   1 
ATOM 826  C CA  . LEU A 1 108 ? 232.098 108.574 274.607 1.00 60.93  ? 108 LEU A CA  1 
ATOM 827  C C   . LEU A 1 108 ? 233.557 108.852 274.268 1.00 66.99  ? 108 LEU A C   1 
ATOM 828  O O   . LEU A 1 108 ? 234.300 109.283 275.146 1.00 70.70  ? 108 LEU A O   1 
ATOM 829  C CB  . LEU A 1 108 ? 231.949 107.192 275.235 1.00 66.53  ? 108 LEU A CB  1 
ATOM 830  C CG  . LEU A 1 108 ? 230.624 106.881 275.925 1.00 65.82  ? 108 LEU A CG  1 
ATOM 831  C CD1 . LEU A 1 108 ? 230.737 105.479 276.488 1.00 72.22  ? 108 LEU A CD1 1 
ATOM 832  C CD2 . LEU A 1 108 ? 230.290 107.861 277.015 1.00 68.57  ? 108 LEU A CD2 1 
ATOM 833  N N   . GLU A 1 109 ? 233.991 108.536 273.041 1.00 67.91  ? 109 GLU A N   1 
ATOM 834  C CA  . GLU A 1 109 ? 235.365 108.791 272.650 1.00 69.39  ? 109 GLU A CA  1 
ATOM 835  C C   . GLU A 1 109 ? 235.565 110.290 272.511 1.00 62.89  ? 109 GLU A C   1 
ATOM 836  O O   . GLU A 1 109 ? 236.564 110.837 272.970 1.00 68.06  ? 109 GLU A O   1 
ATOM 837  C CB  . GLU A 1 109 ? 235.755 108.107 271.345 1.00 77.25  ? 109 GLU A CB  1 
ATOM 838  C CG  . GLU A 1 109 ? 235.901 106.598 271.506 1.00 88.58  ? 109 GLU A CG  1 
ATOM 839  C CD  . GLU A 1 109 ? 236.656 105.893 270.384 1.00 99.08  ? 109 GLU A CD  1 
ATOM 840  O OE1 . GLU A 1 109 ? 237.195 106.598 269.484 1.00 100.54 ? 109 GLU A OE1 1 
ATOM 841  O OE2 . GLU A 1 109 ? 236.677 104.616 270.401 1.00 100.13 ? 109 GLU A OE2 1 
ATOM 842  N N   . LYS A 1 110 ? 234.598 110.943 271.899 1.00 53.54  ? 110 LYS A N   1 
ATOM 843  C CA  . LYS A 1 110 ? 234.668 112.373 271.742 1.00 57.46  ? 110 LYS A CA  1 
ATOM 844  C C   . LYS A 1 110 ? 234.586 113.085 273.096 1.00 59.01  ? 110 LYS A C   1 
ATOM 845  O O   . LYS A 1 110 ? 235.204 114.127 273.268 1.00 67.30  ? 110 LYS A O   1 
ATOM 846  C CB  . LYS A 1 110 ? 233.588 112.699 270.718 1.00 64.03  ? 110 LYS A CB  1 
ATOM 847  C CG  . LYS A 1 110 ? 233.429 114.148 270.363 1.00 74.28  ? 110 LYS A CG  1 
ATOM 848  C CD  . LYS A 1 110 ? 232.624 114.347 269.084 1.00 78.76  ? 110 LYS A CD  1 
ATOM 849  C CE  . LYS A 1 110 ? 232.344 115.801 268.860 1.00 89.23  ? 110 LYS A CE  1 
ATOM 850  N NZ  . LYS A 1 110 ? 231.377 116.014 267.773 1.00 94.88  ? 110 LYS A NZ  1 
ATOM 851  N N   . ILE A 1 111 ? 233.834 112.538 274.051 1.00 60.21  ? 111 ILE A N   1 
ATOM 852  C CA  . ILE A 1 111 ? 233.755 113.066 275.403 1.00 59.37  ? 111 ILE A CA  1 
ATOM 853  C C   . ILE A 1 111 ? 235.090 112.832 276.096 1.00 56.38  ? 111 ILE A C   1 
ATOM 854  O O   . ILE A 1 111 ? 235.568 113.704 276.799 1.00 64.60  ? 111 ILE A O   1 
ATOM 855  C CB  . ILE A 1 111 ? 232.592 112.429 276.202 1.00 63.51  ? 111 ILE A CB  1 
ATOM 856  C CG1 . ILE A 1 111 ? 231.202 112.867 275.715 1.00 64.89  ? 111 ILE A CG1 1 
ATOM 857  C CG2 . ILE A 1 111 ? 232.733 112.680 277.700 1.00 66.93  ? 111 ILE A CG2 1 
ATOM 858  C CD1 . ILE A 1 111 ? 230.805 114.276 276.102 1.00 69.80  ? 111 ILE A CD1 1 
ATOM 859  N N   . SER A 1 112 ? 235.685 111.660 275.937 1.00 56.92  ? 112 SER A N   1 
ATOM 860  C CA  . SER A 1 112 ? 236.954 111.398 276.590 1.00 64.31  ? 112 SER A CA  1 
ATOM 861  C C   . SER A 1 112 ? 237.979 112.441 276.163 1.00 69.07  ? 112 SER A C   1 
ATOM 862  O O   . SER A 1 112 ? 238.740 112.949 276.982 1.00 74.53  ? 112 SER A O   1 
ATOM 863  C CB  . SER A 1 112 ? 237.478 110.026 276.286 1.00 68.28  ? 112 SER A CB  1 
ATOM 864  O OG  . SER A 1 112 ? 236.656 109.026 276.862 1.00 78.47  ? 112 SER A OG  1 
ATOM 865  N N   . ALA A 1 113 ? 237.995 112.726 274.862 1.00 68.91  ? 113 ALA A N   1 
ATOM 866  C CA  . ALA A 1 113 ? 238.913 113.688 274.291 1.00 67.32  ? 113 ALA A CA  1 
ATOM 867  C C   . ALA A 1 113 ? 238.674 115.060 274.901 1.00 62.44  ? 113 ALA A C   1 
ATOM 868  O O   . ALA A 1 113 ? 239.614 115.703 275.350 1.00 68.37  ? 113 ALA A O   1 
ATOM 869  C CB  . ALA A 1 113 ? 238.735 113.703 272.793 1.00 73.41  ? 113 ALA A CB  1 
ATOM 870  N N   . LEU A 1 114 ? 237.414 115.488 274.912 1.00 63.11  ? 114 LEU A N   1 
ATOM 871  C CA  . LEU A 1 114 ? 237.030 116.792 275.425 1.00 63.44  ? 114 LEU A CA  1 
ATOM 872  C C   . LEU A 1 114 ? 237.459 116.951 276.876 1.00 63.07  ? 114 LEU A C   1 
ATOM 873  O O   . LEU A 1 114 ? 237.927 118.003 277.276 1.00 66.67  ? 114 LEU A O   1 
ATOM 874  C CB  . LEU A 1 114 ? 235.522 116.928 275.290 1.00 64.93  ? 114 LEU A CB  1 
ATOM 875  C CG  . LEU A 1 114 ? 234.901 118.172 275.916 1.00 70.99  ? 114 LEU A CG  1 
ATOM 876  C CD1 . LEU A 1 114 ? 235.302 119.383 275.115 1.00 75.65  ? 114 LEU A CD1 1 
ATOM 877  C CD2 . LEU A 1 114 ? 233.384 118.097 276.003 1.00 77.83  ? 114 LEU A CD2 1 
ATOM 878  N N   . MET A 1 115 ? 237.284 115.905 277.669 1.00 68.09  ? 115 MET A N   1 
ATOM 879  C CA  . MET A 1 115 ? 237.604 115.968 279.079 1.00 69.44  ? 115 MET A CA  1 
ATOM 880  C C   . MET A 1 115 ? 239.108 116.081 279.257 1.00 68.86  ? 115 MET A C   1 
ATOM 881  O O   . MET A 1 115 ? 239.554 116.809 280.130 1.00 75.11  ? 115 MET A O   1 
ATOM 882  C CB  . MET A 1 115 ? 237.103 114.722 279.819 1.00 72.59  ? 115 MET A CB  1 
ATOM 883  C CG  . MET A 1 115 ? 235.592 114.623 279.965 1.00 73.42  ? 115 MET A CG  1 
ATOM 884  S SD  . MET A 1 115 ? 234.841 116.018 280.825 1.00 79.51  ? 115 MET A SD  1 
ATOM 885  C CE  . MET A 1 115 ? 234.229 116.973 279.428 1.00 83.38  ? 115 MET A CE  1 
ATOM 886  N N   . ASP A 1 116 ? 239.886 115.333 278.480 1.00 71.13  ? 116 ASP A N   1 
ATOM 887  C CA  . ASP A 1 116 ? 241.326 115.392 278.628 1.00 75.64  ? 116 ASP A CA  1 
ATOM 888  C C   . ASP A 1 116 ? 241.815 116.780 278.262 1.00 74.52  ? 116 ASP A C   1 
ATOM 889  O O   . ASP A 1 116 ? 242.666 117.336 278.948 1.00 82.56  ? 116 ASP A O   1 
ATOM 890  C CB  . ASP A 1 116 ? 242.034 114.351 277.787 1.00 86.68  ? 116 ASP A CB  1 
ATOM 891  C CG  . ASP A 1 116 ? 241.826 112.914 278.261 1.00 101.74 ? 116 ASP A CG  1 
ATOM 892  O OD1 . ASP A 1 116 ? 241.096 112.719 279.288 1.00 104.81 ? 116 ASP A OD1 1 
ATOM 893  O OD2 . ASP A 1 116 ? 242.380 111.992 277.592 1.00 107.97 ? 116 ASP A OD2 1 
ATOM 894  N N   . LYS A 1 117 ? 241.260 117.335 277.189 1.00 70.39  ? 117 LYS A N   1 
ATOM 895  C CA  . LYS A 1 117 ? 241.642 118.660 276.751 1.00 68.21  ? 117 LYS A CA  1 
ATOM 896  C C   . LYS A 1 117 ? 241.316 119.661 277.851 1.00 68.50  ? 117 LYS A C   1 
ATOM 897  O O   . LYS A 1 117 ? 242.180 120.432 278.252 1.00 78.77  ? 117 LYS A O   1 
ATOM 898  C CB  . LYS A 1 117 ? 240.928 119.008 275.448 1.00 69.92  ? 117 LYS A CB  1 
ATOM 899  C CG  . LYS A 1 117 ? 241.383 120.296 274.827 1.00 73.35  ? 117 LYS A CG  1 
ATOM 900  C CD  . LYS A 1 117 ? 241.022 120.457 273.358 1.00 78.93  ? 117 LYS A CD  1 
ATOM 901  C CE  . LYS A 1 117 ? 241.572 121.740 272.827 1.00 84.88  ? 117 LYS A CE  1 
ATOM 902  N NZ  . LYS A 1 117 ? 241.011 122.129 271.531 1.00 89.72  ? 117 LYS A NZ  1 
ATOM 903  N N   . PHE A 1 118 ? 240.087 119.623 278.361 1.00 67.22  ? 118 PHE A N   1 
ATOM 904  C CA  . PHE A 1 118 ? 239.665 120.485 279.451 1.00 62.58  ? 118 PHE A CA  1 
ATOM 905  C C   . PHE A 1 118 ? 240.683 120.486 280.576 1.00 56.58  ? 118 PHE A C   1 
ATOM 906  O O   . PHE A 1 118 ? 241.001 121.539 281.104 1.00 63.16  ? 118 PHE A O   1 
ATOM 907  C CB  . PHE A 1 118 ? 238.315 119.980 279.957 1.00 62.88  ? 118 PHE A CB  1 
ATOM 908  C CG  . PHE A 1 118 ? 237.765 120.690 281.175 1.00 57.47  ? 118 PHE A CG  1 
ATOM 909  C CD1 . PHE A 1 118 ? 238.146 120.294 282.446 1.00 61.14  ? 118 PHE A CD1 1 
ATOM 910  C CD2 . PHE A 1 118 ? 236.845 121.717 281.038 1.00 55.73  ? 118 PHE A CD2 1 
ATOM 911  C CE1 . PHE A 1 118 ? 237.643 120.943 283.559 1.00 64.24  ? 118 PHE A CE1 1 
ATOM 912  C CE2 . PHE A 1 118 ? 236.346 122.361 282.147 1.00 59.98  ? 118 PHE A CE2 1 
ATOM 913  C CZ  . PHE A 1 118 ? 236.744 121.975 283.405 1.00 64.74  ? 118 PHE A CZ  1 
ATOM 914  N N   . GLU A 1 119 ? 241.155 119.320 280.968 1.00 58.13  ? 119 GLU A N   1 
ATOM 915  C CA  . GLU A 1 119 ? 242.039 119.240 282.105 1.00 69.98  ? 119 GLU A CA  1 
ATOM 916  C C   . GLU A 1 119 ? 243.398 119.831 281.772 1.00 71.83  ? 119 GLU A C   1 
ATOM 917  O O   . GLU A 1 119 ? 243.991 120.506 282.607 1.00 73.85  ? 119 GLU A O   1 
ATOM 918  C CB  . GLU A 1 119 ? 242.237 117.793 282.539 1.00 80.67  ? 119 GLU A CB  1 
ATOM 919  C CG  . GLU A 1 119 ? 243.238 117.627 283.681 1.00 89.94  ? 119 GLU A CG  1 
ATOM 920  C CD  . GLU A 1 119 ? 243.272 116.216 284.241 1.00 102.46 ? 119 GLU A CD  1 
ATOM 921  O OE1 . GLU A 1 119 ? 242.704 115.309 283.579 1.00 111.40 ? 119 GLU A OE1 1 
ATOM 922  O OE2 . GLU A 1 119 ? 243.837 116.012 285.346 1.00 108.81 ? 119 GLU A OE2 1 
ATOM 923  N N   . HIS A 1 120 ? 243.903 119.524 280.576 1.00 76.40  ? 120 HIS A N   1 
ATOM 924  C CA  . HIS A 1 120 ? 245.221 119.971 280.151 1.00 78.13  ? 120 HIS A CA  1 
ATOM 925  C C   . HIS A 1 120 ? 245.258 121.493 280.020 1.00 62.78  ? 120 HIS A C   1 
ATOM 926  O O   . HIS A 1 120 ? 246.259 122.104 280.350 1.00 65.66  ? 120 HIS A O   1 
ATOM 927  C CB  . HIS A 1 120 ? 245.631 119.226 278.874 1.00 89.19  ? 120 HIS A CB  1 
ATOM 928  C CG  . HIS A 1 120 ? 246.893 119.742 278.279 1.00 105.85 ? 120 HIS A CG  1 
ATOM 929  N ND1 . HIS A 1 120 ? 248.141 119.462 278.808 1.00 112.91 ? 120 HIS A ND1 1 
ATOM 930  C CD2 . HIS A 1 120 ? 247.096 120.577 277.230 1.00 113.20 ? 120 HIS A CD2 1 
ATOM 931  C CE1 . HIS A 1 120 ? 249.068 120.095 278.085 1.00 119.11 ? 120 HIS A CE1 1 
ATOM 932  N NE2 . HIS A 1 120 ? 248.457 120.776 277.118 1.00 118.21 ? 120 HIS A NE2 1 
ATOM 933  N N   . GLN A 1 121 ? 244.171 122.099 279.570 1.00 54.72  ? 121 GLN A N   1 
ATOM 934  C CA  . GLN A 1 121 ? 244.112 123.539 279.449 1.00 54.49  ? 121 GLN A CA  1 
ATOM 935  C C   . GLN A 1 121 ? 244.048 124.241 280.796 1.00 55.09  ? 121 GLN A C   1 
ATOM 936  O O   . GLN A 1 121 ? 244.383 125.413 280.868 1.00 62.16  ? 121 GLN A O   1 
ATOM 937  C CB  . GLN A 1 121 ? 242.880 123.977 278.681 1.00 59.08  ? 121 GLN A CB  1 
ATOM 938  C CG  . GLN A 1 121 ? 242.929 123.572 277.219 1.00 61.95  ? 121 GLN A CG  1 
ATOM 939  C CD  . GLN A 1 121 ? 241.729 124.079 276.462 1.00 72.80  ? 121 GLN A CD  1 
ATOM 940  O OE1 . GLN A 1 121 ? 240.697 124.446 277.044 1.00 80.01  ? 121 GLN A OE1 1 
ATOM 941  N NE2 . GLN A 1 121 ? 241.861 124.110 275.146 1.00 73.97  ? 121 GLN A NE2 1 
ATOM 942  N N   . PHE A 1 122 ? 243.557 123.581 281.836 1.00 58.34  ? 122 PHE A N   1 
ATOM 943  C CA  . PHE A 1 122 ? 243.512 124.195 283.145 1.00 57.30  ? 122 PHE A CA  1 
ATOM 944  C C   . PHE A 1 122 ? 244.855 123.996 283.826 1.00 59.45  ? 122 PHE A C   1 
ATOM 945  O O   . PHE A 1 122 ? 245.196 124.755 284.725 1.00 69.30  ? 122 PHE A O   1 
ATOM 946  C CB  . PHE A 1 122 ? 242.327 123.683 283.959 1.00 60.08  ? 122 PHE A CB  1 
ATOM 947  C CG  . PHE A 1 122 ? 241.099 124.529 283.690 1.00 59.51  ? 122 PHE A CG  1 
ATOM 948  C CD1 . PHE A 1 122 ? 241.021 125.810 284.207 1.00 65.30  ? 122 PHE A CD1 1 
ATOM 949  C CD2 . PHE A 1 122 ? 240.047 124.063 282.924 1.00 61.60  ? 122 PHE A CD2 1 
ATOM 950  C CE1 . PHE A 1 122 ? 239.929 126.615 283.951 1.00 66.18  ? 122 PHE A CE1 1 
ATOM 951  C CE2 . PHE A 1 122 ? 238.948 124.866 282.681 1.00 65.84  ? 122 PHE A CE2 1 
ATOM 952  C CZ  . PHE A 1 122 ? 238.897 126.142 283.189 1.00 68.01  ? 122 PHE A CZ  1 
ATOM 953  N N   . GLU A 1 123 ? 245.610 122.990 283.408 1.00 61.34  ? 123 GLU A N   1 
ATOM 954  C CA  . GLU A 1 123 ? 246.979 122.885 283.861 1.00 70.60  ? 123 GLU A CA  1 
ATOM 955  C C   . GLU A 1 123 ? 247.779 124.041 283.283 1.00 72.38  ? 123 GLU A C   1 
ATOM 956  O O   . GLU A 1 123 ? 248.649 124.582 283.955 1.00 81.01  ? 123 GLU A O   1 
ATOM 957  C CB  . GLU A 1 123 ? 247.648 121.580 283.443 1.00 82.78  ? 123 GLU A CB  1 
ATOM 958  C CG  . GLU A 1 123 ? 247.165 120.351 284.213 1.00 93.48  ? 123 GLU A CG  1 
ATOM 959  C CD  . GLU A 1 123 ? 247.796 119.039 283.746 1.00 102.06 ? 123 GLU A CD  1 
ATOM 960  O OE1 . GLU A 1 123 ? 248.534 119.071 282.721 1.00 108.59 ? 123 GLU A OE1 1 
ATOM 961  O OE2 . GLU A 1 123 ? 247.566 117.978 284.390 1.00 104.24 ? 123 GLU A OE2 1 
ATOM 962  N N   . THR A 1 124 ? 247.496 124.411 282.034 1.00 69.48  ? 124 THR A N   1 
ATOM 963  C CA  . THR A 1 124 ? 248.181 125.528 281.406 1.00 65.52  ? 124 THR A CA  1 
ATOM 964  C C   . THR A 1 124 ? 247.840 126.819 282.145 1.00 65.13  ? 124 THR A C   1 
ATOM 965  O O   . THR A 1 124 ? 248.759 127.555 282.519 1.00 69.40  ? 124 THR A O   1 
ATOM 966  C CB  . THR A 1 124 ? 247.823 125.593 279.924 1.00 68.00  ? 124 THR A CB  1 
ATOM 967  O OG1 . THR A 1 124 ? 248.409 124.455 279.299 1.00 71.36  ? 124 THR A OG1 1 
ATOM 968  C CG2 . THR A 1 124 ? 248.415 126.797 279.231 1.00 72.98  ? 124 THR A CG2 1 
ATOM 969  N N   . LEU A 1 125 ? 246.556 127.082 282.415 1.00 66.70  ? 125 LEU A N   1 
ATOM 970  C CA  . LEU A 1 125 ? 246.133 128.344 282.994 1.00 68.08  ? 125 LEU A CA  1 
ATOM 971  C C   . LEU A 1 125 ? 246.592 128.460 284.445 1.00 72.62  ? 125 LEU A C   1 
ATOM 972  O O   . LEU A 1 125 ? 246.385 129.492 285.084 1.00 80.31  ? 125 LEU A O   1 
ATOM 973  C CB  . LEU A 1 125 ? 244.618 128.461 282.864 1.00 71.03  ? 125 LEU A CB  1 
ATOM 974  C CG  . LEU A 1 125 ? 243.952 129.658 283.559 1.00 80.29  ? 125 LEU A CG  1 
ATOM 975  C CD1 . LEU A 1 125 ? 244.506 131.031 283.118 1.00 83.31  ? 125 LEU A CD1 1 
ATOM 976  C CD2 . LEU A 1 125 ? 242.465 129.629 283.324 1.00 82.22  ? 125 LEU A CD2 1 
ATOM 977  N N   . ASP A 1 126 ? 247.189 127.385 284.984 1.00 72.57  ? 126 ASP A N   1 
ATOM 978  C CA  . ASP A 1 126 ? 247.762 127.379 286.361 1.00 79.90  ? 126 ASP A CA  1 
ATOM 979  C C   . ASP A 1 126 ? 249.246 127.725 286.250 1.00 79.68  ? 126 ASP A C   1 
ATOM 980  O O   . ASP A 1 126 ? 249.769 128.352 287.188 1.00 87.47  ? 126 ASP A O   1 
ATOM 981  C CB  . ASP A 1 126 ? 247.549 126.030 287.024 1.00 92.41  ? 126 ASP A CB  1 
ATOM 982  C CG  . ASP A 1 126 ? 247.847 125.976 288.515 1.00 111.65 ? 126 ASP A CG  1 
ATOM 983  O OD1 . ASP A 1 126 ? 248.058 127.052 289.113 1.00 115.55 ? 126 ASP A OD1 1 
ATOM 984  O OD2 . ASP A 1 126 ? 247.872 124.855 289.064 1.00 117.94 ? 126 ASP A OD2 1 
ATOM 985  N N   . VAL A 1 127 ? 249.909 127.277 285.182 1.00 76.96  ? 127 VAL A N   1 
ATOM 986  C CA  . VAL A 1 127 ? 251.286 127.644 284.908 1.00 71.09  ? 127 VAL A CA  1 
ATOM 987  C C   . VAL A 1 127 ? 251.306 129.140 284.626 1.00 67.99  ? 127 VAL A C   1 
ATOM 988  O O   . VAL A 1 127 ? 252.250 129.828 285.009 1.00 71.86  ? 127 VAL A O   1 
ATOM 989  C CB  . VAL A 1 127 ? 251.841 126.806 283.739 1.00 71.63  ? 127 VAL A CB  1 
ATOM 990  C CG1 . VAL A 1 127 ? 252.962 127.493 282.981 1.00 74.06  ? 127 VAL A CG1 1 
ATOM 991  C CG2 . VAL A 1 127 ? 252.314 125.443 284.216 1.00 78.08  ? 127 VAL A CG2 1 
ATOM 992  N N   . GLN A 1 128 ? 250.244 129.632 283.989 1.00 67.34  ? 128 GLN A N   1 
ATOM 993  C CA  . GLN A 1 128 ? 250.182 131.018 283.586 1.00 66.21  ? 128 GLN A CA  1 
ATOM 994  C C   . GLN A 1 128 ? 250.006 131.892 284.820 1.00 70.04  ? 128 GLN A C   1 
ATOM 995  O O   . GLN A 1 128 ? 250.699 132.891 284.950 1.00 75.36  ? 128 GLN A O   1 
ATOM 996  C CB  . GLN A 1 128 ? 249.072 131.247 282.563 1.00 69.18  ? 128 GLN A CB  1 
ATOM 997  C CG  . GLN A 1 128 ? 248.650 132.702 282.429 1.00 72.73  ? 128 GLN A CG  1 
ATOM 998  C CD  . GLN A 1 128 ? 247.644 132.916 281.329 1.00 76.98  ? 128 GLN A CD  1 
ATOM 999  O OE1 . GLN A 1 128 ? 247.334 131.994 280.565 1.00 81.48  ? 128 GLN A OE1 1 
ATOM 1000 N NE2 . GLN A 1 128 ? 247.128 134.137 281.238 1.00 79.10  ? 128 GLN A NE2 1 
ATOM 1001 N N   . THR A 1 129 ? 249.081 131.547 285.721 1.00 74.36  ? 129 THR A N   1 
ATOM 1002 C CA  . THR A 1 129 ? 248.851 132.402 286.880 1.00 78.39  ? 129 THR A CA  1 
ATOM 1003 C C   . THR A 1 129 ? 250.059 132.339 287.802 1.00 72.94  ? 129 THR A C   1 
ATOM 1004 O O   . THR A 1 129 ? 250.332 133.302 288.499 1.00 76.28  ? 129 THR A O   1 
ATOM 1005 C CB  . THR A 1 129 ? 247.576 132.061 287.658 1.00 82.40  ? 129 THR A CB  1 
ATOM 1006 O OG1 . THR A 1 129 ? 247.723 130.738 288.169 1.00 81.38  ? 129 THR A OG1 1 
ATOM 1007 C CG2 . THR A 1 129 ? 246.334 132.230 286.796 1.00 85.64  ? 129 THR A CG2 1 
ATOM 1008 N N   . GLN A 1 130 ? 250.764 131.216 287.816 1.00 74.11  ? 130 GLN A N   1 
ATOM 1009 C CA  . GLN A 1 130 ? 251.941 131.116 288.652 1.00 80.53  ? 130 GLN A CA  1 
ATOM 1010 C C   . GLN A 1 130 ? 252.956 132.160 288.220 1.00 81.21  ? 130 GLN A C   1 
ATOM 1011 O O   . GLN A 1 130 ? 253.513 132.851 289.068 1.00 84.59  ? 130 GLN A O   1 
ATOM 1012 C CB  . GLN A 1 130 ? 252.598 129.744 288.570 1.00 89.13  ? 130 GLN A CB  1 
ATOM 1013 C CG  . GLN A 1 130 ? 253.834 129.586 289.449 1.00 93.10  ? 130 GLN A CG  1 
ATOM 1014 C CD  . GLN A 1 130 ? 253.539 129.832 290.916 1.00 99.04  ? 130 GLN A CD  1 
ATOM 1015 O OE1 . GLN A 1 130 ? 252.543 129.337 291.464 1.00 102.85 ? 130 GLN A OE1 1 
ATOM 1016 N NE2 . GLN A 1 130 ? 254.393 130.610 291.567 1.00 98.77  ? 130 GLN A NE2 1 
ATOM 1017 N N   . GLN A 1 131 ? 253.175 132.290 286.908 1.00 83.24  ? 131 GLN A N   1 
ATOM 1018 C CA  . GLN A 1 131 ? 254.229 133.166 286.417 1.00 82.53  ? 131 GLN A CA  1 
ATOM 1019 C C   . GLN A 1 131 ? 253.778 134.624 286.400 1.00 75.38  ? 131 GLN A C   1 
ATOM 1020 O O   . GLN A 1 131 ? 254.639 135.500 286.373 1.00 84.71  ? 131 GLN A O   1 
ATOM 1021 C CB  . GLN A 1 131 ? 254.806 132.746 285.066 1.00 84.15  ? 131 GLN A CB  1 
ATOM 1022 C CG  . GLN A 1 131 ? 253.878 132.932 283.875 1.00 84.68  ? 131 GLN A CG  1 
ATOM 1023 C CD  . GLN A 1 131 ? 254.519 132.446 282.596 1.00 89.06  ? 131 GLN A CD  1 
ATOM 1024 O OE1 . GLN A 1 131 ? 255.677 132.005 282.595 1.00 92.83  ? 131 GLN A OE1 1 
ATOM 1025 N NE2 . GLN A 1 131 ? 253.776 132.507 281.498 1.00 88.72  ? 131 GLN A NE2 1 
ATOM 1026 N N   . MET A 1 132 ? 252.477 134.902 286.420 1.00 73.42  ? 132 MET A N   1 
ATOM 1027 C CA  . MET A 1 132 ? 252.017 136.255 286.693 1.00 77.73  ? 132 MET A CA  1 
ATOM 1028 C C   . MET A 1 132 ? 252.236 136.621 288.155 1.00 76.71  ? 132 MET A C   1 
ATOM 1029 O O   . MET A 1 132 ? 252.642 137.732 288.456 1.00 77.86  ? 132 MET A O   1 
ATOM 1030 C CB  . MET A 1 132 ? 250.533 136.424 286.367 1.00 86.70  ? 132 MET A CB  1 
ATOM 1031 C CG  . MET A 1 132 ? 250.277 136.452 284.865 1.00 97.54  ? 132 MET A CG  1 
ATOM 1032 S SD  . MET A 1 132 ? 248.542 136.319 284.382 1.00 112.87 ? 132 MET A SD  1 
ATOM 1033 C CE  . MET A 1 132 ? 247.903 137.833 285.125 1.00 113.73 ? 132 MET A CE  1 
ATOM 1034 N N   . GLU A 1 133 ? 252.009 135.676 289.059 1.00 82.11  ? 133 GLU A N   1 
ATOM 1035 C CA  . GLU A 1 133 ? 252.139 135.929 290.483 1.00 87.80  ? 133 GLU A CA  1 
ATOM 1036 C C   . GLU A 1 133 ? 253.605 136.102 290.871 1.00 84.72  ? 133 GLU A C   1 
ATOM 1037 O O   . GLU A 1 133 ? 253.892 136.819 291.827 1.00 87.00  ? 133 GLU A O   1 
ATOM 1038 C CB  . GLU A 1 133 ? 251.476 134.794 291.266 1.00 97.96  ? 133 GLU A CB  1 
ATOM 1039 C CG  . GLU A 1 133 ? 249.950 134.822 291.174 1.00 106.90 ? 133 GLU A CG  1 
ATOM 1040 C CD  . GLU A 1 133 ? 249.224 133.657 291.841 1.00 120.14 ? 133 GLU A CD  1 
ATOM 1041 O OE1 . GLU A 1 133 ? 249.276 132.502 291.325 1.00 128.01 ? 133 GLU A OE1 1 
ATOM 1042 O OE2 . GLU A 1 133 ? 248.582 133.926 292.894 1.00 122.43 ? 133 GLU A OE2 1 
ATOM 1043 N N   . ASP A 1 134 ? 254.518 135.444 290.152 1.00 83.75  ? 134 ASP A N   1 
ATOM 1044 C CA  . ASP A 1 134 ? 255.943 135.609 290.392 1.00 90.09  ? 134 ASP A CA  1 
ATOM 1045 C C   . ASP A 1 134 ? 256.453 136.889 289.734 1.00 86.02  ? 134 ASP A C   1 
ATOM 1046 O O   . ASP A 1 134 ? 257.457 137.448 290.161 1.00 85.79  ? 134 ASP A O   1 
ATOM 1047 C CB  . ASP A 1 134 ? 256.733 134.416 289.889 1.00 101.47 ? 134 ASP A CB  1 
ATOM 1048 C CG  . ASP A 1 134 ? 256.297 133.079 290.469 1.00 115.83 ? 134 ASP A CG  1 
ATOM 1049 O OD1 . ASP A 1 134 ? 255.959 133.055 291.693 1.00 117.03 ? 134 ASP A OD1 1 
ATOM 1050 O OD2 . ASP A 1 134 ? 256.325 132.068 289.695 1.00 123.56 ? 134 ASP A OD2 1 
ATOM 1051 N N   . THR A 1 135 ? 255.819 137.371 288.681 1.00 84.55  ? 135 THR A N   1 
ATOM 1052 C CA  . THR A 1 135 ? 256.196 138.635 288.049 1.00 80.72  ? 135 THR A CA  1 
ATOM 1053 C C   . THR A 1 135 ? 255.799 139.749 288.989 1.00 79.07  ? 135 THR A C   1 
ATOM 1054 O O   . THR A 1 135 ? 256.564 140.697 289.089 1.00 84.48  ? 135 THR A O   1 
ATOM 1055 C CB  . THR A 1 135 ? 255.524 138.779 286.692 1.00 86.65  ? 135 THR A CB  1 
ATOM 1056 O OG1 . THR A 1 135 ? 256.326 137.995 285.818 1.00 92.39  ? 135 THR A OG1 1 
ATOM 1057 C CG2 . THR A 1 135 ? 255.479 140.219 286.223 1.00 86.86  ? 135 THR A CG2 1 
ATOM 1058 N N   . VAL A 1 136 ? 254.642 139.658 289.644 1.00 74.99  ? 136 VAL A N   1 
ATOM 1059 C CA  . VAL A 1 136 ? 254.221 140.741 290.517 1.00 69.91  ? 136 VAL A CA  1 
ATOM 1060 C C   . VAL A 1 136 ? 255.063 140.711 291.786 1.00 69.98  ? 136 VAL A C   1 
ATOM 1061 O O   . VAL A 1 136 ? 255.387 141.761 292.319 1.00 74.55  ? 136 VAL A O   1 
ATOM 1062 C CB  . VAL A 1 136 ? 252.717 140.655 290.831 1.00 70.63  ? 136 VAL A CB  1 
ATOM 1063 C CG1 . VAL A 1 136 ? 252.238 141.769 291.754 1.00 73.05  ? 136 VAL A CG1 1 
ATOM 1064 C CG2 . VAL A 1 136 ? 251.889 140.637 289.558 1.00 72.43  ? 136 VAL A CG2 1 
ATOM 1065 N N   . SER A 1 137 ? 255.405 139.517 292.264 1.00 76.57  ? 137 SER A N   1 
ATOM 1066 C CA  . SER A 1 137 ? 256.173 139.371 293.486 1.00 85.15  ? 137 SER A CA  1 
ATOM 1067 C C   . SER A 1 137 ? 257.560 139.991 293.332 1.00 86.89  ? 137 SER A C   1 
ATOM 1068 O O   . SER A 1 137 ? 258.059 140.594 294.279 1.00 90.93  ? 137 SER A O   1 
ATOM 1069 C CB  . SER A 1 137 ? 256.269 137.916 293.904 1.00 90.87  ? 137 SER A CB  1 
ATOM 1070 O OG  . SER A 1 137 ? 256.910 137.764 295.166 1.00 96.78  ? 137 SER A OG  1 
ATOM 1071 N N   . SER A 1 138 ? 258.199 139.825 292.168 1.00 88.16  ? 138 SER A N   1 
ATOM 1072 C CA  . SER A 1 138 ? 259.538 140.373 291.981 1.00 93.31  ? 138 SER A CA  1 
ATOM 1073 C C   . SER A 1 138 ? 259.464 141.860 291.644 1.00 87.25  ? 138 SER A C   1 
ATOM 1074 O O   . SER A 1 138 ? 260.363 142.615 291.993 1.00 87.56  ? 138 SER A O   1 
ATOM 1075 C CB  . SER A 1 138 ? 260.342 139.637 290.928 1.00 98.64  ? 138 SER A CB  1 
ATOM 1076 O OG  . SER A 1 138 ? 259.935 140.038 289.616 1.00 100.50 ? 138 SER A OG  1 
ATOM 1077 N N   . THR A 1 139 ? 258.420 142.315 290.976 1.00 86.64  ? 139 THR A N   1 
ATOM 1078 C CA  . THR A 1 139 ? 258.251 143.734 290.623 1.00 85.87  ? 139 THR A CA  1 
ATOM 1079 C C   . THR A 1 139 ? 258.063 144.519 291.894 1.00 85.37  ? 139 THR A C   1 
ATOM 1080 O O   . THR A 1 139 ? 258.560 145.645 291.927 1.00 89.94  ? 139 THR A O   1 
ATOM 1081 C CB  . THR A 1 139 ? 257.079 143.889 289.667 1.00 85.83  ? 139 THR A CB  1 
ATOM 1082 O OG1 . THR A 1 139 ? 257.603 143.524 288.398 1.00 88.13  ? 139 THR A OG1 1 
ATOM 1083 C CG2 . THR A 1 139 ? 256.544 145.307 289.638 1.00 87.59  ? 139 THR A CG2 1 
ATOM 1084 N N   . THR A 1 140 ? 257.369 143.982 292.901 1.00 84.00  ? 140 THR A N   1 
ATOM 1085 C CA  . THR A 1 140 ? 257.100 144.743 294.108 1.00 85.33  ? 140 THR A CA  1 
ATOM 1086 C C   . THR A 1 140 ? 257.994 144.253 295.249 1.00 84.46  ? 140 THR A C   1 
ATOM 1087 O O   . THR A 1 140 ? 257.602 144.303 296.423 1.00 84.45  ? 140 THR A O   1 
ATOM 1088 C CB  . THR A 1 140 ? 255.617 144.624 294.460 1.00 89.34  ? 140 THR A CB  1 
ATOM 1089 O OG1 . THR A 1 140 ? 255.390 143.273 294.855 1.00 92.22  ? 140 THR A OG1 1 
ATOM 1090 C CG2 . THR A 1 140 ? 254.706 145.006 293.305 1.00 90.92  ? 140 THR A CG2 1 
ATOM 1091 N N   . THR A 1 141 ? 259.206 143.801 294.924 1.00 84.44  ? 141 THR A N   1 
ATOM 1092 C CA  . THR A 1 141 ? 260.021 143.114 295.914 1.00 87.93  ? 141 THR A CA  1 
ATOM 1093 C C   . THR A 1 141 ? 260.502 144.061 297.013 1.00 92.34  ? 141 THR A C   1 
ATOM 1094 O O   . THR A 1 141 ? 260.820 143.577 298.097 1.00 95.67  ? 141 THR A O   1 
ATOM 1095 C CB  . THR A 1 141 ? 261.200 142.412 295.240 1.00 90.92  ? 141 THR A CB  1 
ATOM 1096 O OG1 . THR A 1 141 ? 261.838 141.632 296.246 1.00 94.19  ? 141 THR A OG1 1 
ATOM 1097 C CG2 . THR A 1 141 ? 262.254 143.350 294.687 1.00 92.18  ? 141 THR A CG2 1 
ATOM 1098 N N   . LEU A 1 142 ? 260.574 145.380 296.754 1.00 93.57  ? 142 LEU A N   1 
ATOM 1099 C CA  . LEU A 1 142 ? 261.144 146.305 297.725 1.00 91.65  ? 142 LEU A CA  1 
ATOM 1100 C C   . LEU A 1 142 ? 260.070 146.804 298.679 1.00 91.17  ? 142 LEU A C   1 
ATOM 1101 O O   . LEU A 1 142 ? 260.390 147.334 299.738 1.00 93.91  ? 142 LEU A O   1 
ATOM 1102 C CB  . LEU A 1 142 ? 261.836 147.470 297.028 1.00 93.39  ? 142 LEU A CB  1 
ATOM 1103 C CG  . LEU A 1 142 ? 263.173 147.146 296.354 1.00 95.20  ? 142 LEU A CG  1 
ATOM 1104 C CD1 . LEU A 1 142 ? 263.692 148.368 295.617 1.00 99.48  ? 142 LEU A CD1 1 
ATOM 1105 C CD2 . LEU A 1 142 ? 264.222 146.636 297.334 1.00 96.74  ? 142 LEU A CD2 1 
ATOM 1106 N N   . THR A 1 143 ? 258.808 146.622 298.299 1.00 92.09  ? 143 THR A N   1 
ATOM 1107 C CA  . THR A 1 143 ? 257.702 147.088 299.106 1.00 93.90  ? 143 THR A CA  1 
ATOM 1108 C C   . THR A 1 143 ? 257.428 146.079 300.225 1.00 100.65 ? 143 THR A C   1 
ATOM 1109 O O   . THR A 1 143 ? 256.983 146.491 301.294 1.00 106.10 ? 143 THR A O   1 
ATOM 1110 C CB  . THR A 1 143 ? 256.505 147.320 298.189 1.00 94.79  ? 143 THR A CB  1 
ATOM 1111 O OG1 . THR A 1 143 ? 256.943 148.236 297.191 1.00 95.70  ? 143 THR A OG1 1 
ATOM 1112 C CG2 . THR A 1 143 ? 255.338 147.974 298.894 1.00 98.74  ? 143 THR A CG2 1 
ATOM 1113 N N   . THR A 1 144 ? 257.700 144.778 300.001 1.00 100.87 ? 144 THR A N   1 
ATOM 1114 C CA  . THR A 1 144 ? 257.565 143.764 301.042 1.00 99.91  ? 144 THR A CA  1 
ATOM 1115 C C   . THR A 1 144 ? 258.904 143.069 301.238 1.00 100.56 ? 144 THR A C   1 
ATOM 1116 O O   . THR A 1 144 ? 259.141 142.018 300.648 1.00 103.06 ? 144 THR A O   1 
ATOM 1117 C CB  . THR A 1 144 ? 256.492 142.724 300.712 1.00 102.13 ? 144 THR A CB  1 
ATOM 1118 O OG1 . THR A 1 144 ? 256.881 142.071 299.507 1.00 104.56 ? 144 THR A OG1 1 
ATOM 1119 C CG2 . THR A 1 144 ? 255.113 143.330 300.536 1.00 105.66 ? 144 THR A CG2 1 
ATOM 1120 N N   . PRO A 1 145 ? 259.816 143.614 302.070 1.00 101.71 ? 145 PRO A N   1 
ATOM 1121 C CA  . PRO A 1 145 ? 261.020 142.881 302.455 1.00 105.14 ? 145 PRO A CA  1 
ATOM 1122 C C   . PRO A 1 145 ? 260.690 141.669 303.325 1.00 107.48 ? 145 PRO A C   1 
ATOM 1123 O O   . PRO A 1 145 ? 259.789 141.732 304.156 1.00 106.73 ? 145 PRO A O   1 
ATOM 1124 C CB  . PRO A 1 145 ? 261.862 143.912 303.206 1.00 106.51 ? 145 PRO A CB  1 
ATOM 1125 C CG  . PRO A 1 145 ? 261.238 145.237 302.830 1.00 106.32 ? 145 PRO A CG  1 
ATOM 1126 C CD  . PRO A 1 145 ? 259.765 144.960 302.651 1.00 101.57 ? 145 PRO A CD  1 
ATOM 1127 N N   . GLN A 1 146 ? 261.446 140.581 303.138 1.00 112.09 ? 146 GLN A N   1 
ATOM 1128 C CA  . GLN A 1 146 ? 261.173 139.317 303.802 1.00 115.73 ? 146 GLN A CA  1 
ATOM 1129 C C   . GLN A 1 146 ? 261.218 139.495 305.321 1.00 115.90 ? 146 GLN A C   1 
ATOM 1130 O O   . GLN A 1 146 ? 260.320 139.024 306.015 1.00 119.01 ? 146 GLN A O   1 
ATOM 1131 C CB  . GLN A 1 146 ? 262.153 138.245 303.315 1.00 119.83 ? 146 GLN A CB  1 
ATOM 1132 C CG  . GLN A 1 146 ? 261.842 136.827 303.789 1.00 123.72 ? 146 GLN A CG  1 
ATOM 1133 C CD  . GLN A 1 146 ? 260.513 136.304 303.281 1.00 127.75 ? 146 GLN A CD  1 
ATOM 1134 O OE1 . GLN A 1 146 ? 260.258 136.274 302.069 1.00 129.67 ? 146 GLN A OE1 1 
ATOM 1135 N NE2 . GLN A 1 146 ? 259.649 135.884 304.199 1.00 128.83 ? 146 GLN A NE2 1 
ATOM 1136 N N   . ASN A 1 147 ? 262.237 140.193 305.834 1.00 115.32 ? 147 ASN A N   1 
ATOM 1137 C CA  . ASN A 1 147 ? 262.472 140.290 307.267 1.00 117.15 ? 147 ASN A CA  1 
ATOM 1138 C C   . ASN A 1 147 ? 261.348 141.040 307.985 1.00 114.20 ? 147 ASN A C   1 
ATOM 1139 O O   . ASN A 1 147 ? 261.096 140.760 309.154 1.00 117.71 ? 147 ASN A O   1 
ATOM 1140 C CB  . ASN A 1 147 ? 263.835 140.906 307.560 1.00 122.50 ? 147 ASN A CB  1 
ATOM 1141 C CG  . ASN A 1 147 ? 263.928 142.353 307.127 1.00 130.01 ? 147 ASN A CG  1 
ATOM 1142 O OD1 . ASN A 1 147 ? 263.875 142.651 305.927 1.00 131.22 ? 147 ASN A OD1 1 
ATOM 1143 N ND2 . ASN A 1 147 ? 264.078 143.271 308.074 1.00 133.34 ? 147 ASN A ND2 1 
ATOM 1144 N N   . GLN A 1 148 ? 260.687 141.991 307.318 1.00 112.53 ? 148 GLN A N   1 
ATOM 1145 C CA  . GLN A 1 148 ? 259.584 142.727 307.925 1.00 114.00 ? 148 GLN A CA  1 
ATOM 1146 C C   . GLN A 1 148 ? 258.331 141.857 308.047 1.00 113.10 ? 148 GLN A C   1 
ATOM 1147 O O   . GLN A 1 148 ? 257.579 142.016 309.009 1.00 114.43 ? 148 GLN A O   1 
ATOM 1148 C CB  . GLN A 1 148 ? 259.267 144.001 307.143 1.00 115.75 ? 148 GLN A CB  1 
ATOM 1149 C CG  . GLN A 1 148 ? 260.408 145.015 307.136 1.00 117.56 ? 148 GLN A CG  1 
ATOM 1150 C CD  . GLN A 1 148 ? 260.012 146.370 306.582 1.00 118.29 ? 148 GLN A CD  1 
ATOM 1151 O OE1 . GLN A 1 148 ? 258.838 146.646 306.310 1.00 115.14 ? 148 GLN A OE1 1 
ATOM 1152 N NE2 . GLN A 1 148 ? 260.992 147.247 306.418 1.00 121.43 ? 148 GLN A NE2 1 
ATOM 1153 N N   . VAL A 1 149 ? 258.101 140.962 307.075 1.00 111.21 ? 149 VAL A N   1 
ATOM 1154 C CA  . VAL A 1 149 ? 256.986 140.028 307.126 1.00 109.84 ? 149 VAL A CA  1 
ATOM 1155 C C   . VAL A 1 149 ? 257.254 139.001 308.223 1.00 111.82 ? 149 VAL A C   1 
ATOM 1156 O O   . VAL A 1 149 ? 256.374 138.749 309.039 1.00 114.52 ? 149 VAL A O   1 
ATOM 1157 C CB  . VAL A 1 149 ? 256.702 139.358 305.768 1.00 109.61 ? 149 VAL A CB  1 
ATOM 1158 C CG1 . VAL A 1 149 ? 255.538 138.380 305.836 1.00 111.12 ? 149 VAL A CG1 1 
ATOM 1159 C CG2 . VAL A 1 149 ? 256.411 140.383 304.680 1.00 110.62 ? 149 VAL A CG2 1 
ATOM 1160 N N   . ASP A 1 150 ? 258.478 138.467 308.278 1.00 113.94 ? 150 ASP A N   1 
ATOM 1161 C CA  . ASP A 1 150 ? 258.858 137.453 309.300 1.00 117.43 ? 150 ASP A CA  1 
ATOM 1162 C C   . ASP A 1 150 ? 258.689 138.027 310.708 1.00 119.06 ? 150 ASP A C   1 
ATOM 1163 O O   . ASP A 1 150 ? 258.263 137.264 311.588 1.00 122.67 ? 150 ASP A O   1 
ATOM 1164 C CB  . ASP A 1 150 ? 260.296 136.999 309.123 1.00 120.80 ? 150 ASP A CB  1 
ATOM 1165 C CG  . ASP A 1 150 ? 260.592 136.245 307.836 1.00 125.88 ? 150 ASP A CG  1 
ATOM 1166 O OD1 . ASP A 1 150 ? 259.851 135.287 307.535 1.00 126.90 ? 150 ASP A OD1 1 
ATOM 1167 O OD2 . ASP A 1 150 ? 261.565 136.623 307.154 1.00 128.66 ? 150 ASP A OD2 1 
ATOM 1168 N N   . MET A 1 151 ? 259.085 139.285 310.923 1.00 119.55 ? 151 MET A N   1 
ATOM 1169 C CA  . MET A 1 151 ? 258.988 139.925 312.230 1.00 120.82 ? 151 MET A CA  1 
ATOM 1170 C C   . MET A 1 151 ? 257.541 140.234 312.605 1.00 117.81 ? 151 MET A C   1 
ATOM 1171 O O   . MET A 1 151 ? 257.193 140.129 313.779 1.00 121.89 ? 151 MET A O   1 
ATOM 1172 C CB  . MET A 1 151 ? 259.816 141.212 312.273 1.00 126.54 ? 151 MET A CB  1 
ATOM 1173 C CG  . MET A 1 151 ? 261.313 140.943 312.372 1.00 133.08 ? 151 MET A CG  1 
ATOM 1174 S SD  . MET A 1 151 ? 262.356 142.408 312.200 1.00 143.06 ? 151 MET A SD  1 
ATOM 1175 C CE  . MET A 1 151 ? 261.915 143.331 313.681 1.00 142.09 ? 151 MET A CE  1 
ATOM 1176 N N   . LEU A 1 152 ? 256.706 140.628 311.641 1.00 114.81 ? 152 LEU A N   1 
ATOM 1177 C CA  . LEU A 1 152 ? 255.302 140.882 311.921 1.00 113.11 ? 152 LEU A CA  1 
ATOM 1178 C C   . LEU A 1 152 ? 254.588 139.573 312.265 1.00 117.15 ? 152 LEU A C   1 
ATOM 1179 O O   . LEU A 1 152 ? 253.791 139.547 313.198 1.00 119.51 ? 152 LEU A O   1 
ATOM 1180 C CB  . LEU A 1 152 ? 254.642 141.604 310.749 1.00 110.41 ? 152 LEU A CB  1 
ATOM 1181 C CG  . LEU A 1 152 ? 253.140 141.876 310.885 1.00 110.24 ? 152 LEU A CG  1 
ATOM 1182 C CD1 . LEU A 1 152 ? 252.800 142.722 312.102 1.00 111.54 ? 152 LEU A CD1 1 
ATOM 1183 C CD2 . LEU A 1 152 ? 252.606 142.546 309.632 1.00 110.20 ? 152 LEU A CD2 1 
ATOM 1184 N N   . LEU A 1 153 ? 254.873 138.490 311.530 1.00 120.79 ? 153 LEU A N   1 
ATOM 1185 C CA  . LEU A 1 153 ? 254.285 137.192 311.836 1.00 121.80 ? 153 LEU A CA  1 
ATOM 1186 C C   . LEU A 1 153 ? 254.688 136.763 313.245 1.00 124.69 ? 153 LEU A C   1 
ATOM 1187 O O   . LEU A 1 153 ? 253.840 136.297 313.998 1.00 127.79 ? 153 LEU A O   1 
ATOM 1188 C CB  . LEU A 1 153 ? 254.669 136.139 310.796 1.00 121.75 ? 153 LEU A CB  1 
ATOM 1189 C CG  . LEU A 1 153 ? 253.914 136.201 309.464 1.00 120.95 ? 153 LEU A CG  1 
ATOM 1190 C CD1 . LEU A 1 153 ? 254.541 135.247 308.454 1.00 122.06 ? 153 LEU A CD1 1 
ATOM 1191 C CD2 . LEU A 1 153 ? 252.435 135.884 309.625 1.00 120.43 ? 153 LEU A CD2 1 
ATOM 1192 N N   . GLN A 1 154 ? 255.961 136.934 313.615 1.00 127.84 ? 154 GLN A N   1 
ATOM 1193 C CA  . GLN A 1 154 ? 256.413 136.558 314.948 1.00 131.35 ? 154 GLN A CA  1 
ATOM 1194 C C   . GLN A 1 154 ? 255.709 137.400 316.018 1.00 132.33 ? 154 GLN A C   1 
ATOM 1195 O O   . GLN A 1 154 ? 255.289 136.860 317.037 1.00 135.37 ? 154 GLN A O   1 
ATOM 1196 C CB  . GLN A 1 154 ? 257.936 136.640 315.060 1.00 133.47 ? 154 GLN A CB  1 
ATOM 1197 C CG  . GLN A 1 154 ? 258.494 136.043 316.349 1.00 137.02 ? 154 GLN A CG  1 
ATOM 1198 C CD  . GLN A 1 154 ? 258.233 134.555 316.488 1.00 141.25 ? 154 GLN A CD  1 
ATOM 1199 O OE1 . GLN A 1 154 ? 258.665 133.750 315.647 1.00 142.82 ? 154 GLN A OE1 1 
ATOM 1200 N NE2 . GLN A 1 154 ? 257.538 134.160 317.550 1.00 143.08 ? 154 GLN A NE2 1 
ATOM 1201 N N   . GLU A 1 155 ? 255.573 138.710 315.790 1.00 133.71 ? 155 GLU A N   1 
ATOM 1202 C CA  . GLU A 1 155 ? 254.887 139.604 316.715 1.00 135.55 ? 155 GLU A CA  1 
ATOM 1203 C C   . GLU A 1 155 ? 253.430 139.180 316.918 1.00 135.11 ? 155 GLU A C   1 
ATOM 1204 O O   . GLU A 1 155 ? 252.959 139.153 318.052 1.00 137.25 ? 155 GLU A O   1 
ATOM 1205 C CB  . GLU A 1 155 ? 255.008 141.032 316.180 1.00 140.06 ? 155 GLU A CB  1 
ATOM 1206 C CG  . GLU A 1 155 ? 254.293 142.098 317.009 1.00 144.12 ? 155 GLU A CG  1 
ATOM 1207 C CD  . GLU A 1 155 ? 254.381 143.491 316.400 1.00 148.18 ? 155 GLU A CD  1 
ATOM 1208 O OE1 . GLU A 1 155 ? 255.489 143.880 315.952 1.00 150.13 ? 155 GLU A OE1 1 
ATOM 1209 O OE2 . GLU A 1 155 ? 253.341 144.197 316.385 1.00 149.42 ? 155 GLU A OE2 1 
ATOM 1210 N N   . MET A 1 156 ? 252.715 138.871 315.831 1.00 134.76 ? 156 MET A N   1 
ATOM 1211 C CA  . MET A 1 156 ? 251.323 138.447 315.912 1.00 134.93 ? 156 MET A CA  1 
ATOM 1212 C C   . MET A 1 156 ? 251.210 137.078 316.586 1.00 135.23 ? 156 MET A C   1 
ATOM 1213 O O   . MET A 1 156 ? 250.234 136.841 317.291 1.00 136.17 ? 156 MET A O   1 
ATOM 1214 C CB  . MET A 1 156 ? 250.695 138.408 314.513 1.00 136.93 ? 156 MET A CB  1 
ATOM 1215 C CG  . MET A 1 156 ? 250.572 139.773 313.836 1.00 137.26 ? 156 MET A CG  1 
ATOM 1216 S SD  . MET A 1 156 ? 249.328 140.880 314.533 1.00 139.70 ? 156 MET A SD  1 
ATOM 1217 C CE  . MET A 1 156 ? 250.371 141.897 315.588 1.00 140.25 ? 156 MET A CE  1 
ATOM 1218 N N   . ALA A 1 157 ? 252.192 136.189 316.365 1.00 136.47 ? 157 ALA A N   1 
ATOM 1219 C CA  . ALA A 1 157 ? 252.230 134.882 317.007 1.00 138.30 ? 157 ALA A CA  1 
ATOM 1220 C C   . ALA A 1 157 ? 252.477 135.017 318.515 1.00 139.46 ? 157 ALA A C   1 
ATOM 1221 O O   . ALA A 1 157 ? 251.849 134.307 319.299 1.00 141.79 ? 157 ALA A O   1 
ATOM 1222 C CB  . ALA A 1 157 ? 253.272 134.007 316.333 1.00 138.81 ? 157 ALA A CB  1 
ATOM 1223 N N   . ASP A 1 158 ? 253.376 135.925 318.921 1.00 139.82 ? 158 ASP A N   1 
ATOM 1224 C CA  . ASP A 1 158 ? 253.627 136.205 320.331 1.00 142.32 ? 158 ASP A CA  1 
ATOM 1225 C C   . ASP A 1 158 ? 252.355 136.692 321.037 1.00 140.77 ? 158 ASP A C   1 
ATOM 1226 O O   . ASP A 1 158 ? 252.058 136.232 322.137 1.00 140.69 ? 158 ASP A O   1 
ATOM 1227 C CB  . ASP A 1 158 ? 254.780 137.186 320.514 1.00 145.59 ? 158 ASP A CB  1 
ATOM 1228 C CG  . ASP A 1 158 ? 256.173 136.674 320.154 1.00 148.39 ? 158 ASP A CG  1 
ATOM 1229 O OD1 . ASP A 1 158 ? 256.304 135.463 319.845 1.00 147.41 ? 158 ASP A OD1 1 
ATOM 1230 O OD2 . ASP A 1 158 ? 257.123 137.491 320.187 1.00 150.66 ? 158 ASP A OD2 1 
ATOM 1231 N N   . GLU A 1 159 ? 251.612 137.620 320.419 1.00 141.61 ? 159 GLU A N   1 
ATOM 1232 C CA  . GLU A 1 159 ? 250.358 138.115 320.981 1.00 143.84 ? 159 GLU A CA  1 
ATOM 1233 C C   . GLU A 1 159 ? 249.280 137.027 321.037 1.00 143.34 ? 159 GLU A C   1 
ATOM 1234 O O   . GLU A 1 159 ? 248.431 137.056 321.927 1.00 143.01 ? 159 GLU A O   1 
ATOM 1235 C CB  . GLU A 1 159 ? 249.832 139.318 320.193 1.00 148.15 ? 159 GLU A CB  1 
ATOM 1236 C CG  . GLU A 1 159 ? 250.643 140.594 320.412 1.00 151.80 ? 159 GLU A CG  1 
ATOM 1237 C CD  . GLU A 1 159 ? 249.945 141.862 319.940 1.00 156.50 ? 159 GLU A CD  1 
ATOM 1238 O OE1 . GLU A 1 159 ? 249.054 141.782 319.055 1.00 157.36 ? 159 GLU A OE1 1 
ATOM 1239 O OE2 . GLU A 1 159 ? 250.279 142.940 320.490 1.00 159.70 ? 159 GLU A OE2 1 
ATOM 1240 N N   . ALA A 1 160 ? 249.298 136.085 320.083 1.00 143.62 ? 160 ALA A N   1 
ATOM 1241 C CA  . ALA A 1 160 ? 248.369 134.958 320.058 1.00 143.45 ? 160 ALA A CA  1 
ATOM 1242 C C   . ALA A 1 160 ? 248.754 133.853 321.050 1.00 144.46 ? 160 ALA A C   1 
ATOM 1243 O O   . ALA A 1 160 ? 247.954 132.949 321.294 1.00 145.58 ? 160 ALA A O   1 
ATOM 1244 C CB  . ALA A 1 160 ? 248.305 134.412 318.650 1.00 142.98 ? 160 ALA A CB  1 
ATOM 1245 N N   . GLY A 1 161 ? 249.970 133.912 321.616 1.00 144.56 ? 161 GLY A N   1 
ATOM 1246 C CA  . GLY A 1 161 ? 250.474 132.881 322.516 1.00 145.73 ? 161 GLY A CA  1 
ATOM 1247 C C   . GLY A 1 161 ? 250.888 131.594 321.795 1.00 148.83 ? 161 GLY A C   1 
ATOM 1248 O O   . GLY A 1 161 ? 250.827 130.514 322.384 1.00 151.12 ? 161 GLY A O   1 
ATOM 1249 N N   . LEU A 1 162 ? 251.344 131.717 320.540 1.00 150.71 ? 162 LEU A N   1 
ATOM 1250 C CA  . LEU A 1 162 ? 251.704 130.584 319.698 1.00 152.53 ? 162 LEU A CA  1 
ATOM 1251 C C   . LEU A 1 162 ? 253.229 130.457 319.629 1.00 156.07 ? 162 LEU A C   1 
ATOM 1252 O O   . LEU A 1 162 ? 253.920 131.432 319.326 1.00 156.02 ? 162 LEU A O   1 
ATOM 1253 C CB  . LEU A 1 162 ? 251.064 130.812 318.327 1.00 152.03 ? 162 LEU A CB  1 
ATOM 1254 C CG  . LEU A 1 162 ? 251.470 129.849 317.206 1.00 152.29 ? 162 LEU A CG  1 
ATOM 1255 C CD1 . LEU A 1 162 ? 251.064 128.406 317.476 1.00 154.32 ? 162 LEU A CD1 1 
ATOM 1256 C CD2 . LEU A 1 162 ? 250.867 130.312 315.912 1.00 151.15 ? 162 LEU A CD2 1 
ATOM 1257 N N   . ASP A 1 163 ? 253.752 129.248 319.897 1.00 161.78 ? 163 ASP A N   1 
ATOM 1258 C CA  . ASP A 1 163 ? 255.190 129.017 320.042 1.00 166.72 ? 163 ASP A CA  1 
ATOM 1259 C C   . ASP A 1 163 ? 255.897 128.786 318.696 1.00 166.79 ? 163 ASP A C   1 
ATOM 1260 O O   . ASP A 1 163 ? 257.126 128.698 318.672 1.00 167.46 ? 163 ASP A O   1 
ATOM 1261 C CB  . ASP A 1 163 ? 255.460 127.872 321.016 1.00 170.88 ? 163 ASP A CB  1 
ATOM 1262 C CG  . ASP A 1 163 ? 255.108 128.125 322.481 1.00 173.85 ? 163 ASP A CG  1 
ATOM 1263 O OD1 . ASP A 1 163 ? 254.862 129.305 322.843 1.00 174.27 ? 163 ASP A OD1 1 
ATOM 1264 O OD2 . ASP A 1 163 ? 255.081 127.137 323.259 1.00 175.57 ? 163 ASP A OD2 1 
ATOM 1265 N N   . LEU A 1 164 ? 255.144 128.692 317.587 1.00 166.59 ? 164 LEU A N   1 
ATOM 1266 C CA  . LEU A 1 164 ? 255.701 128.395 316.269 1.00 167.57 ? 164 LEU A CA  1 
ATOM 1267 C C   . LEU A 1 164 ? 256.614 129.534 315.801 1.00 167.86 ? 164 LEU A C   1 
ATOM 1268 O O   . LEU A 1 164 ? 256.166 130.678 315.718 1.00 167.05 ? 164 LEU A O   1 
ATOM 1269 C CB  . LEU A 1 164 ? 254.550 128.153 315.285 1.00 168.51 ? 164 LEU A CB  1 
ATOM 1270 C CG  . LEU A 1 164 ? 254.926 127.650 313.881 1.00 169.86 ? 164 LEU A CG  1 
ATOM 1271 C CD1 . LEU A 1 164 ? 255.542 126.248 313.915 1.00 170.55 ? 164 LEU A CD1 1 
ATOM 1272 C CD2 . LEU A 1 164 ? 253.717 127.648 312.946 1.00 170.12 ? 164 LEU A CD2 1 
ATOM 1273 N N   . ASN A 1 165 ? 257.886 129.211 315.490 1.00 168.54 ? 165 ASN A N   1 
ATOM 1274 C CA  . ASN A 1 165 ? 258.878 130.178 315.025 1.00 169.74 ? 165 ASN A CA  1 
ATOM 1275 C C   . ASN A 1 165 ? 258.567 130.588 313.578 1.00 169.18 ? 165 ASN A C   1 
ATOM 1276 O O   . ASN A 1 165 ? 258.394 129.720 312.715 1.00 169.64 ? 165 ASN A O   1 
ATOM 1277 C CB  . ASN A 1 165 ? 260.290 129.611 315.191 1.00 170.99 ? 165 ASN A CB  1 
ATOM 1278 C CG  . ASN A 1 165 ? 261.390 130.602 314.868 1.00 172.20 ? 165 ASN A CG  1 
ATOM 1279 O OD1 . ASN A 1 165 ? 261.396 131.207 313.790 1.00 171.93 ? 165 ASN A OD1 1 
ATOM 1280 N ND2 . ASN A 1 165 ? 262.345 130.783 315.773 1.00 172.42 ? 165 ASN A ND2 1 
ATOM 1281 N N   . MET A 1 166 ? 258.519 131.911 313.313 1.00 167.98 ? 166 MET A N   1 
ATOM 1282 C CA  . MET A 1 166 ? 258.066 132.432 312.020 1.00 167.35 ? 166 MET A CA  1 
ATOM 1283 C C   . MET A 1 166 ? 259.230 132.894 311.128 1.00 168.87 ? 166 MET A C   1 
ATOM 1284 O O   . MET A 1 166 ? 259.009 133.163 309.948 1.00 168.32 ? 166 MET A O   1 
ATOM 1285 C CB  . MET A 1 166 ? 257.052 133.570 312.225 1.00 165.14 ? 166 MET A CB  1 
ATOM 1286 C CG  . MET A 1 166 ? 255.792 133.133 312.977 1.00 163.64 ? 166 MET A CG  1 
ATOM 1287 S SD  . MET A 1 166 ? 254.841 131.832 312.159 1.00 163.76 ? 166 MET A SD  1 
ATOM 1288 C CE  . MET A 1 166 ? 253.466 131.691 313.309 1.00 162.27 ? 166 MET A CE  1 
ATOM 1289 N N   . GLU A 1 167 ? 260.460 132.965 311.666 1.00 171.56 ? 167 GLU A N   1 
ATOM 1290 C CA  . GLU A 1 167 ? 261.653 133.243 310.867 1.00 173.99 ? 167 GLU A CA  1 
ATOM 1291 C C   . GLU A 1 167 ? 262.094 131.968 310.137 1.00 174.62 ? 167 GLU A C   1 
ATOM 1292 O O   . GLU A 1 167 ? 262.473 132.030 308.967 1.00 173.95 ? 167 GLU A O   1 
ATOM 1293 C CB  . GLU A 1 167 ? 262.761 133.839 311.747 1.00 176.07 ? 167 GLU A CB  1 
ATOM 1294 C CG  . GLU A 1 167 ? 264.055 134.192 311.009 1.00 177.89 ? 167 GLU A CG  1 
ATOM 1295 C CD  . GLU A 1 167 ? 265.180 134.736 311.885 1.00 180.20 ? 167 GLU A CD  1 
ATOM 1296 O OE1 . GLU A 1 167 ? 264.897 135.508 312.838 1.00 180.75 ? 167 GLU A OE1 1 
ATOM 1297 O OE2 . GLU A 1 167 ? 266.357 134.402 311.593 1.00 180.75 ? 167 GLU A OE2 1 
ATOM 1298 N N   . LEU A 1 168 ? 262.041 130.821 310.837 1.00 175.17 ? 168 LEU A N   1 
ATOM 1299 C CA  . LEU A 1 168 ? 262.433 129.522 310.292 1.00 175.09 ? 168 LEU A CA  1 
ATOM 1300 C C   . LEU A 1 168 ? 261.387 129.008 309.298 1.00 175.74 ? 168 LEU A C   1 
ATOM 1301 O O   . LEU A 1 168 ? 260.223 129.411 309.365 1.00 174.96 ? 168 LEU A O   1 
ATOM 1302 C CB  . LEU A 1 168 ? 262.636 128.525 311.439 1.00 174.26 ? 168 LEU A CB  1 
ATOM 1303 C CG  . LEU A 1 168 ? 263.782 128.822 312.419 1.00 173.96 ? 168 LEU A CG  1 
ATOM 1304 C CD1 . LEU A 1 168 ? 263.809 127.791 313.544 1.00 173.74 ? 168 LEU A CD1 1 
ATOM 1305 C CD2 . LEU A 1 168 ? 265.143 128.869 311.730 1.00 172.91 ? 168 LEU A CD2 1 
ATOM 1306 N N   . PRO A 1 169 ? 261.758 128.102 308.350 1.00 176.64 ? 169 PRO A N   1 
ATOM 1307 C CA  . PRO A 1 169 ? 260.776 127.440 307.486 1.00 177.82 ? 169 PRO A CA  1 
ATOM 1308 C C   . PRO A 1 169 ? 259.924 126.421 308.250 1.00 179.65 ? 169 PRO A C   1 
ATOM 1309 O O   . PRO A 1 169 ? 260.419 125.754 309.162 1.00 179.35 ? 169 PRO A O   1 
ATOM 1310 C CB  . PRO A 1 169 ? 261.639 126.777 306.392 1.00 176.88 ? 169 PRO A CB  1 
ATOM 1311 C CG  . PRO A 1 169 ? 262.965 126.508 307.074 1.00 175.95 ? 169 PRO A CG  1 
ATOM 1312 C CD  . PRO A 1 169 ? 263.135 127.671 308.042 1.00 175.93 ? 169 PRO A CD  1 
ATOM 1313 N N   . GLN A 1 170 ? 258.645 126.310 307.851 1.00 181.06 ? 170 GLN A N   1 
ATOM 1314 C CA  . GLN A 1 170 ? 257.666 125.441 308.498 1.00 182.17 ? 170 GLN A CA  1 
ATOM 1315 C C   . GLN A 1 170 ? 256.858 124.684 307.421 1.00 183.51 ? 170 GLN A C   1 
ATOM 1316 O O   . GLN A 1 170 ? 256.432 125.348 306.442 1.00 183.82 ? 170 GLN A O   1 
ATOM 1317 C CB  . GLN A 1 170 ? 256.725 126.227 309.424 1.00 181.34 ? 170 GLN A CB  1 
ATOM 1318 C CG  . GLN A 1 170 ? 257.406 127.053 310.521 1.00 181.04 ? 170 GLN A CG  1 
ATOM 1319 C CD  . GLN A 1 170 ? 258.153 126.244 311.569 1.00 181.36 ? 170 GLN A CD  1 
ATOM 1320 O OE1 . GLN A 1 170 ? 258.082 125.009 311.615 1.00 182.94 ? 170 GLN A OE1 1 
ATOM 1321 N NE2 . GLN A 1 170 ? 258.863 126.931 312.456 1.00 180.24 ? 170 GLN A NE2 1 
ATOM 1322 N N   . ASP A 1 186 ? 252.489 110.303 303.816 1.00 158.34 ? 186 ASP A N   1 
ATOM 1323 C CA  . ASP A 1 186 ? 253.482 110.916 304.748 1.00 159.90 ? 186 ASP A CA  1 
ATOM 1324 C C   . ASP A 1 186 ? 254.593 109.904 305.026 1.00 157.96 ? 186 ASP A C   1 
ATOM 1325 O O   . ASP A 1 186 ? 255.599 109.903 304.318 1.00 158.51 ? 186 ASP A O   1 
ATOM 1326 C CB  . ASP A 1 186 ? 252.817 111.483 306.001 1.00 162.96 ? 186 ASP A CB  1 
ATOM 1327 C CG  . ASP A 1 186 ? 251.695 110.649 306.616 1.00 165.68 ? 186 ASP A CG  1 
ATOM 1328 O OD1 . ASP A 1 186 ? 250.820 110.169 305.854 1.00 167.05 ? 186 ASP A OD1 1 
ATOM 1329 O OD2 . ASP A 1 186 ? 251.689 110.499 307.860 1.00 166.05 ? 186 ASP A OD2 1 
ATOM 1330 N N   . GLU A 1 187 ? 254.416 109.059 306.055 1.00 155.17 ? 187 GLU A N   1 
ATOM 1331 C CA  . GLU A 1 187 ? 255.371 108.000 306.342 1.00 153.82 ? 187 GLU A CA  1 
ATOM 1332 C C   . GLU A 1 187 ? 255.241 106.897 305.287 1.00 150.81 ? 187 GLU A C   1 
ATOM 1333 O O   . GLU A 1 187 ? 256.248 106.301 304.906 1.00 150.28 ? 187 GLU A O   1 
ATOM 1334 C CB  . GLU A 1 187 ? 255.214 107.478 307.775 1.00 156.28 ? 187 GLU A CB  1 
ATOM 1335 C CG  . GLU A 1 187 ? 256.301 106.490 308.207 1.00 158.68 ? 187 GLU A CG  1 
ATOM 1336 C CD  . GLU A 1 187 ? 257.742 106.994 308.243 1.00 161.49 ? 187 GLU A CD  1 
ATOM 1337 O OE1 . GLU A 1 187 ? 257.976 108.228 308.285 1.00 163.22 ? 187 GLU A OE1 1 
ATOM 1338 O OE2 . GLU A 1 187 ? 258.648 106.126 308.224 1.00 161.79 ? 187 GLU A OE2 1 
ATOM 1339 N N   . LEU A 1 188 ? 254.012 106.642 304.810 1.00 147.52 ? 188 LEU A N   1 
ATOM 1340 C CA  . LEU A 1 188 ? 253.778 105.657 303.761 1.00 144.07 ? 188 LEU A CA  1 
ATOM 1341 C C   . LEU A 1 188 ? 254.552 106.046 302.499 1.00 144.27 ? 188 LEU A C   1 
ATOM 1342 O O   . LEU A 1 188 ? 255.146 105.182 301.857 1.00 144.79 ? 188 LEU A O   1 
ATOM 1343 C CB  . LEU A 1 188 ? 252.279 105.510 303.488 1.00 141.53 ? 188 LEU A CB  1 
ATOM 1344 C CG  . LEU A 1 188 ? 251.868 104.545 302.365 1.00 140.02 ? 188 LEU A CG  1 
ATOM 1345 C CD1 . LEU A 1 188 ? 252.288 103.101 302.626 1.00 140.14 ? 188 LEU A CD1 1 
ATOM 1346 C CD2 . LEU A 1 188 ? 250.363 104.620 302.131 1.00 139.63 ? 188 LEU A CD2 1 
ATOM 1347 N N   . SER A 1 189 ? 254.539 107.341 302.150 1.00 143.89 ? 189 SER A N   1 
ATOM 1348 C CA  . SER A 1 189 ? 255.286 107.851 301.009 1.00 144.36 ? 189 SER A CA  1 
ATOM 1349 C C   . SER A 1 189 ? 256.781 107.574 301.172 1.00 144.10 ? 189 SER A C   1 
ATOM 1350 O O   . SER A 1 189 ? 257.446 107.199 300.209 1.00 143.42 ? 189 SER A O   1 
ATOM 1351 C CB  . SER A 1 189 ? 255.026 109.329 300.800 1.00 145.33 ? 189 SER A CB  1 
ATOM 1352 O OG  . SER A 1 189 ? 253.635 109.593 300.668 1.00 146.39 ? 189 SER A OG  1 
ATOM 1353 N N   . GLN A 1 190 ? 257.299 107.757 302.394 1.00 145.64 ? 190 GLN A N   1 
ATOM 1354 C CA  . GLN A 1 190 ? 258.719 107.585 302.671 1.00 147.52 ? 190 GLN A CA  1 
ATOM 1355 C C   . GLN A 1 190 ? 259.090 106.101 302.630 1.00 145.06 ? 190 GLN A C   1 
ATOM 1356 O O   . GLN A 1 190 ? 260.192 105.764 302.197 1.00 144.44 ? 190 GLN A O   1 
ATOM 1357 C CB  . GLN A 1 190 ? 259.111 108.241 304.001 1.00 150.88 ? 190 GLN A CB  1 
ATOM 1358 C CG  . GLN A 1 190 ? 258.915 109.758 304.049 1.00 154.73 ? 190 GLN A CG  1 
ATOM 1359 C CD  . GLN A 1 190 ? 259.798 110.541 303.093 1.00 158.47 ? 190 GLN A CD  1 
ATOM 1360 O OE1 . GLN A 1 190 ? 260.789 110.033 302.550 1.00 160.25 ? 190 GLN A OE1 1 
ATOM 1361 N NE2 . GLN A 1 190 ? 259.455 111.807 302.887 1.00 159.30 ? 190 GLN A NE2 1 
ATOM 1362 N N   . ARG A 1 191 ? 258.177 105.227 303.086 1.00 143.54 ? 191 ARG A N   1 
ATOM 1363 C CA  . ARG A 1 191 ? 258.394 103.788 303.050 1.00 143.58 ? 191 ARG A CA  1 
ATOM 1364 C C   . ARG A 1 191 ? 258.516 103.330 301.597 1.00 140.12 ? 191 ARG A C   1 
ATOM 1365 O O   . ARG A 1 191 ? 259.454 102.614 301.254 1.00 138.83 ? 191 ARG A O   1 
ATOM 1366 C CB  . ARG A 1 191 ? 257.276 103.026 303.779 1.00 147.72 ? 191 ARG A CB  1 
ATOM 1367 C CG  . ARG A 1 191 ? 257.261 103.090 305.304 1.00 150.45 ? 191 ARG A CG  1 
ATOM 1368 C CD  . ARG A 1 191 ? 258.395 102.306 305.974 1.00 154.21 ? 191 ARG A CD  1 
ATOM 1369 N NE  . ARG A 1 191 ? 258.320 100.854 305.760 1.00 158.24 ? 191 ARG A NE  1 
ATOM 1370 C CZ  . ARG A 1 191 ? 259.310 99.967  305.930 1.00 162.34 ? 191 ARG A CZ  1 
ATOM 1371 N NH1 . ARG A 1 191 ? 259.070 98.672  305.758 1.00 163.12 ? 191 ARG A NH1 1 
ATOM 1372 N NH2 . ARG A 1 191 ? 260.530 100.356 306.285 1.00 162.85 ? 191 ARG A NH2 1 
ATOM 1373 N N   . LEU A 1 192 ? 257.565 103.760 300.757 1.00 138.28 ? 192 LEU A N   1 
ATOM 1374 C CA  . LEU A 1 192 ? 257.524 103.376 299.353 1.00 137.12 ? 192 LEU A CA  1 
ATOM 1375 C C   . LEU A 1 192 ? 258.736 103.934 298.605 1.00 137.71 ? 192 LEU A C   1 
ATOM 1376 O O   . LEU A 1 192 ? 259.273 103.253 297.735 1.00 137.78 ? 192 LEU A O   1 
ATOM 1377 C CB  . LEU A 1 192 ? 256.192 103.822 298.742 1.00 136.54 ? 192 LEU A CB  1 
ATOM 1378 C CG  . LEU A 1 192 ? 255.026 102.825 298.826 1.00 135.84 ? 192 LEU A CG  1 
ATOM 1379 C CD1 . LEU A 1 192 ? 254.866 102.140 300.185 1.00 137.01 ? 192 LEU A CD1 1 
ATOM 1380 C CD2 . LEU A 1 192 ? 253.721 103.521 298.449 1.00 133.28 ? 192 LEU A CD2 1 
ATOM 1381 N N   . ALA A 1 193 ? 259.177 105.151 298.954 1.00 139.21 ? 193 ALA A N   1 
ATOM 1382 C CA  . ALA A 1 193 ? 260.392 105.729 298.391 1.00 139.50 ? 193 ALA A CA  1 
ATOM 1383 C C   . ALA A 1 193 ? 261.602 104.831 298.657 1.00 140.04 ? 193 ALA A C   1 
ATOM 1384 O O   . ALA A 1 193 ? 262.389 104.585 297.744 1.00 139.96 ? 193 ALA A O   1 
ATOM 1385 C CB  . ALA A 1 193 ? 260.610 107.122 298.948 1.00 140.29 ? 193 ALA A CB  1 
ATOM 1386 N N   . ARG A 1 194 ? 261.747 104.360 299.905 1.00 142.17 ? 194 ARG A N   1 
ATOM 1387 C CA  . ARG A 1 194 ? 262.847 103.485 300.289 1.00 144.65 ? 194 ARG A CA  1 
ATOM 1388 C C   . ARG A 1 194 ? 262.787 102.177 299.493 1.00 142.45 ? 194 ARG A C   1 
ATOM 1389 O O   . ARG A 1 194 ? 263.820 101.706 299.021 1.00 141.09 ? 194 ARG A O   1 
ATOM 1390 C CB  . ARG A 1 194 ? 262.859 103.290 301.814 1.00 147.67 ? 194 ARG A CB  1 
ATOM 1391 C CG  . ARG A 1 194 ? 263.489 104.452 302.574 1.00 150.48 ? 194 ARG A CG  1 
ATOM 1392 C CD  . ARG A 1 194 ? 263.283 104.394 304.089 1.00 152.86 ? 194 ARG A CD  1 
ATOM 1393 N NE  . ARG A 1 194 ? 261.938 104.822 304.501 1.00 155.03 ? 194 ARG A NE  1 
ATOM 1394 C CZ  . ARG A 1 194 ? 261.467 104.897 305.752 1.00 157.28 ? 194 ARG A CZ  1 
ATOM 1395 N NH1 . ARG A 1 194 ? 260.241 105.356 305.968 1.00 157.56 ? 194 ARG A NH1 1 
ATOM 1396 N NH2 . ARG A 1 194 ? 262.209 104.530 306.787 1.00 157.86 ? 194 ARG A NH2 1 
ATOM 1397 N N   . LEU A 1 195 ? 261.581 101.616 299.321 1.00 141.03 ? 195 LEU A N   1 
ATOM 1398 C CA  . LEU A 1 195 ? 261.377 100.401 298.538 1.00 141.66 ? 195 LEU A CA  1 
ATOM 1399 C C   . LEU A 1 195 ? 261.898 100.567 297.108 1.00 140.87 ? 195 LEU A C   1 
ATOM 1400 O O   . LEU A 1 195 ? 262.541 99.655  296.590 1.00 140.87 ? 195 LEU A O   1 
ATOM 1401 C CB  . LEU A 1 195 ? 259.896 100.010 298.534 1.00 141.90 ? 195 LEU A CB  1 
ATOM 1402 C CG  . LEU A 1 195 ? 259.415 98.998  299.584 1.00 141.83 ? 195 LEU A CG  1 
ATOM 1403 C CD1 . LEU A 1 195 ? 259.883 99.240  301.023 1.00 143.47 ? 195 LEU A CD1 1 
ATOM 1404 C CD2 . LEU A 1 195 ? 257.888 98.965  299.542 1.00 141.33 ? 195 LEU A CD2 1 
ATOM 1405 N N   . ARG A 1 196 ? 261.584 101.704 296.466 1.00 140.05 ? 196 ARG A N   1 
ATOM 1406 C CA  . ARG A 1 196 ? 261.962 101.958 295.080 1.00 140.24 ? 196 ARG A CA  1 
ATOM 1407 C C   . ARG A 1 196 ? 263.482 101.917 294.907 1.00 146.00 ? 196 ARG A C   1 
ATOM 1408 O O   . ARG A 1 196 ? 263.968 101.414 293.893 1.00 146.54 ? 196 ARG A O   1 
ATOM 1409 C CB  . ARG A 1 196 ? 261.491 103.328 294.574 1.00 136.70 ? 196 ARG A CB  1 
ATOM 1410 C CG  . ARG A 1 196 ? 259.991 103.555 294.447 1.00 132.51 ? 196 ARG A CG  1 
ATOM 1411 C CD  . ARG A 1 196 ? 259.659 105.016 294.163 1.00 127.74 ? 196 ARG A CD  1 
ATOM 1412 N NE  . ARG A 1 196 ? 258.404 105.426 294.803 1.00 126.42 ? 196 ARG A NE  1 
ATOM 1413 C CZ  . ARG A 1 196 ? 258.177 106.546 295.498 1.00 126.81 ? 196 ARG A CZ  1 
ATOM 1414 N NH1 . ARG A 1 196 ? 256.999 106.735 296.079 1.00 126.83 ? 196 ARG A NH1 1 
ATOM 1415 N NH2 . ARG A 1 196 ? 259.102 107.485 295.622 1.00 127.21 ? 196 ARG A NH2 1 
ATOM 1416 N N   . ASP A 1 197 ? 264.217 102.473 295.887 1.00 150.63 ? 197 ASP A N   1 
ATOM 1417 C CA  . ASP A 1 197 ? 265.673 102.558 295.842 1.00 154.36 ? 197 ASP A CA  1 
ATOM 1418 C C   . ASP A 1 197 ? 266.317 101.214 296.193 1.00 155.37 ? 197 ASP A C   1 
ATOM 1419 O O   . ASP A 1 197 ? 267.398 100.904 295.688 1.00 156.68 ? 197 ASP A O   1 
ATOM 1420 C CB  . ASP A 1 197 ? 266.189 103.677 296.739 1.00 157.39 ? 197 ASP A CB  1 
ATOM 1421 C CG  . ASP A 1 197 ? 265.945 105.102 296.237 1.00 161.63 ? 197 ASP A CG  1 
ATOM 1422 O OD1 . ASP A 1 197 ? 265.500 105.267 295.035 1.00 163.50 ? 197 ASP A OD1 1 
ATOM 1423 O OD2 . ASP A 1 197 ? 266.181 106.041 297.060 1.00 163.84 ? 197 ASP A OD2 1 
ATOM 1424 N N   . GLN A 1 198 ? 265.648 100.420 297.044 1.00 155.61 ? 198 GLN A N   1 
ATOM 1425 C CA  . GLN A 1 198 ? 266.212 99.187  297.583 1.00 157.56 ? 198 GLN A CA  1 
ATOM 1426 C C   . GLN A 1 198 ? 266.225 98.057  296.546 1.00 158.72 ? 198 GLN A C   1 
ATOM 1427 O O   . GLN A 1 198 ? 267.083 97.177  296.627 1.00 159.99 ? 198 GLN A O   1 
ATOM 1428 C CB  . GLN A 1 198 ? 265.454 98.763  298.847 1.00 158.84 ? 198 GLN A CB  1 
ATOM 1429 C CG  . GLN A 1 198 ? 265.877 99.514  300.108 1.00 159.91 ? 198 GLN A CG  1 
ATOM 1430 C CD  . GLN A 1 198 ? 264.920 99.356  301.275 1.00 161.84 ? 198 GLN A CD  1 
ATOM 1431 O OE1 . GLN A 1 198 ? 263.884 98.681  301.186 1.00 161.33 ? 198 GLN A OE1 1 
ATOM 1432 N NE2 . GLN A 1 198 ? 265.259 99.988  302.393 1.00 162.63 ? 198 GLN A NE2 1 
ATOM 1433 N N   . VAL A 1 199 ? 265.282 98.070  295.588 1.00 158.98 ? 199 VAL A N   1 
ATOM 1434 C CA  . VAL A 1 199 ? 265.148 96.988  294.614 1.00 160.33 ? 199 VAL A CA  1 
ATOM 1435 C C   . VAL A 1 199 ? 266.233 97.137  293.527 1.00 163.15 ? 199 VAL A C   1 
ATOM 1436 O O   . VAL A 1 199 ? 266.620 98.305  293.248 1.00 163.72 ? 199 VAL A O   1 
ATOM 1437 C CB  . VAL A 1 199 ? 263.742 96.867  293.976 1.00 158.38 ? 199 VAL A CB  1 
ATOM 1438 C CG1 . VAL A 1 199 ? 262.714 96.329  294.975 1.00 157.72 ? 199 VAL A CG1 1 
ATOM 1439 C CG2 . VAL A 1 199 ? 263.257 98.167  293.325 1.00 156.84 ? 199 VAL A CG2 1 
ATOM 1440 O OXT . VAL A 1 199 ? 266.655 96.076  292.995 1.00 163.72 ? 199 VAL A OXT 1 
ATOM 1441 N N   . SER B 2 4   ? 271.084 127.606 261.233 1.00 135.59 ? 4   SER B N   1 
ATOM 1442 C CA  . SER B 2 4   ? 270.942 126.833 262.505 1.00 136.60 ? 4   SER B CA  1 
ATOM 1443 C C   . SER B 2 4   ? 269.490 126.861 263.002 1.00 131.95 ? 4   SER B C   1 
ATOM 1444 O O   . SER B 2 4   ? 268.889 125.804 263.219 1.00 130.81 ? 4   SER B O   1 
ATOM 1445 C CB  . SER B 2 4   ? 271.922 127.318 263.586 1.00 136.01 ? 4   SER B CB  1 
ATOM 1446 O OG  . SER B 2 4   ? 271.731 128.695 263.904 1.00 135.73 ? 4   SER B OG  1 
ATOM 1447 N N   . GLY B 2 5   ? 268.942 128.075 263.183 1.00 126.38 ? 5   GLY B N   1 
ATOM 1448 C CA  . GLY B 2 5   ? 267.589 128.263 263.688 1.00 123.15 ? 5   GLY B CA  1 
ATOM 1449 C C   . GLY B 2 5   ? 267.559 128.388 265.212 1.00 119.39 ? 5   GLY B C   1 
ATOM 1450 O O   . GLY B 2 5   ? 266.482 128.511 265.798 1.00 118.93 ? 5   GLY B O   1 
ATOM 1451 N N   . PHE B 2 6   ? 268.744 128.380 265.840 1.00 113.80 ? 6   PHE B N   1 
ATOM 1452 C CA  . PHE B 2 6   ? 268.865 128.485 267.283 1.00 108.91 ? 6   PHE B CA  1 
ATOM 1453 C C   . PHE B 2 6   ? 268.636 129.926 267.723 1.00 108.99 ? 6   PHE B C   1 
ATOM 1454 O O   . PHE B 2 6   ? 269.254 130.845 267.191 1.00 110.91 ? 6   PHE B O   1 
ATOM 1455 C CB  . PHE B 2 6   ? 270.248 128.018 267.733 1.00 108.18 ? 6   PHE B CB  1 
ATOM 1456 C CG  . PHE B 2 6   ? 270.551 128.359 269.181 1.00 108.75 ? 6   PHE B CG  1 
ATOM 1457 C CD1 . PHE B 2 6   ? 269.935 127.664 270.213 1.00 112.42 ? 6   PHE B CD1 1 
ATOM 1458 C CD2 . PHE B 2 6   ? 271.457 129.356 269.510 1.00 110.35 ? 6   PHE B CD2 1 
ATOM 1459 C CE1 . PHE B 2 6   ? 270.220 127.963 271.537 1.00 113.98 ? 6   PHE B CE1 1 
ATOM 1460 C CE2 . PHE B 2 6   ? 271.740 129.650 270.837 1.00 111.95 ? 6   PHE B CE2 1 
ATOM 1461 C CZ  . PHE B 2 6   ? 271.124 128.954 271.847 1.00 111.31 ? 6   PHE B CZ  1 
ATOM 1462 N N   . LYS B 2 7   ? 267.736 130.101 268.696 1.00 110.91 ? 7   LYS B N   1 
ATOM 1463 C CA  . LYS B 2 7   ? 267.470 131.394 269.306 1.00 110.75 ? 7   LYS B CA  1 
ATOM 1464 C C   . LYS B 2 7   ? 267.628 131.249 270.815 1.00 106.84 ? 7   LYS B C   1 
ATOM 1465 O O   . LYS B 2 7   ? 266.876 130.513 271.447 1.00 107.29 ? 7   LYS B O   1 
ATOM 1466 C CB  . LYS B 2 7   ? 266.064 131.892 268.953 1.00 110.63 ? 7   LYS B CB  1 
ATOM 1467 C CG  . LYS B 2 7   ? 265.879 132.253 267.492 1.00 115.16 ? 7   LYS B CG  1 
ATOM 1468 C CD  . LYS B 2 7   ? 264.488 132.764 267.128 1.00 121.48 ? 7   LYS B CD  1 
ATOM 1469 C CE  . LYS B 2 7   ? 264.355 133.083 265.658 1.00 125.87 ? 7   LYS B CE  1 
ATOM 1470 N NZ  . LYS B 2 7   ? 263.001 133.509 265.279 1.00 128.15 ? 7   LYS B NZ  1 
ATOM 1471 N N   . ALA B 2 8   ? 268.600 131.959 271.385 1.00 102.20 ? 8   ALA B N   1 
ATOM 1472 C CA  . ALA B 2 8   ? 268.921 131.780 272.787 1.00 100.41 ? 8   ALA B CA  1 
ATOM 1473 C C   . ALA B 2 8   ? 267.723 132.126 273.669 1.00 99.11  ? 8   ALA B C   1 
ATOM 1474 O O   . ALA B 2 8   ? 267.514 131.466 274.679 1.00 102.47 ? 8   ALA B O   1 
ATOM 1475 C CB  . ALA B 2 8   ? 270.131 132.611 273.152 1.00 106.50 ? 8   ALA B CB  1 
ATOM 1476 N N   . GLU B 2 9   ? 266.930 133.139 273.311 1.00 100.55 ? 9   GLU B N   1 
ATOM 1477 C CA  . GLU B 2 9   ? 265.824 133.528 274.174 1.00 104.97 ? 9   GLU B CA  1 
ATOM 1478 C C   . GLU B 2 9   ? 264.639 132.573 274.044 1.00 102.31 ? 9   GLU B C   1 
ATOM 1479 O O   . GLU B 2 9   ? 263.832 132.499 274.961 1.00 107.99 ? 9   GLU B O   1 
ATOM 1480 C CB  . GLU B 2 9   ? 265.402 134.979 273.955 1.00 112.22 ? 9   GLU B CB  1 
ATOM 1481 C CG  . GLU B 2 9   ? 266.503 135.966 274.348 1.00 120.86 ? 9   GLU B CG  1 
ATOM 1482 C CD  . GLU B 2 9   ? 267.188 135.718 275.694 1.00 126.14 ? 9   GLU B CD  1 
ATOM 1483 O OE1 . GLU B 2 9   ? 266.481 135.493 276.723 1.00 125.59 ? 9   GLU B OE1 1 
ATOM 1484 O OE2 . GLU B 2 9   ? 268.450 135.759 275.700 1.00 127.07 ? 9   GLU B OE2 1 
ATOM 1485 N N   . ARG B 2 10  ? 264.524 131.836 272.939 1.00 95.47  ? 10  ARG B N   1 
ATOM 1486 C CA  . ARG B 2 10  ? 263.562 130.751 272.892 1.00 93.20  ? 10  ARG B CA  1 
ATOM 1487 C C   . ARG B 2 10  ? 263.960 129.674 273.896 1.00 87.85  ? 10  ARG B C   1 
ATOM 1488 O O   . ARG B 2 10  ? 263.099 129.164 274.605 1.00 90.15  ? 10  ARG B O   1 
ATOM 1489 C CB  . ARG B 2 10  ? 263.440 130.135 271.497 1.00 97.90  ? 10  ARG B CB  1 
ATOM 1490 C CG  . ARG B 2 10  ? 262.589 130.959 270.547 1.00 102.91 ? 10  ARG B CG  1 
ATOM 1491 C CD  . ARG B 2 10  ? 261.134 130.558 270.589 1.00 105.36 ? 10  ARG B CD  1 
ATOM 1492 N NE  . ARG B 2 10  ? 260.905 129.278 269.908 1.00 106.73 ? 10  ARG B NE  1 
ATOM 1493 C CZ  . ARG B 2 10  ? 259.713 128.700 269.753 1.00 112.42 ? 10  ARG B CZ  1 
ATOM 1494 N NH1 . ARG B 2 10  ? 259.613 127.583 269.055 1.00 112.37 ? 10  ARG B NH1 1 
ATOM 1495 N NH2 . ARG B 2 10  ? 258.611 129.233 270.271 1.00 115.29 ? 10  ARG B NH2 1 
ATOM 1496 N N   . LEU B 2 11  ? 265.246 129.320 273.941 1.00 82.31  ? 11  LEU B N   1 
ATOM 1497 C CA  . LEU B 2 11  ? 265.700 128.261 274.820 1.00 80.22  ? 11  LEU B CA  1 
ATOM 1498 C C   . LEU B 2 11  ? 265.529 128.708 276.268 1.00 82.95  ? 11  LEU B C   1 
ATOM 1499 O O   . LEU B 2 11  ? 265.112 127.913 277.106 1.00 89.72  ? 11  LEU B O   1 
ATOM 1500 C CB  . LEU B 2 11  ? 267.141 127.865 274.512 1.00 80.53  ? 11  LEU B CB  1 
ATOM 1501 C CG  . LEU B 2 11  ? 267.769 126.813 275.429 1.00 85.21  ? 11  LEU B CG  1 
ATOM 1502 C CD1 . LEU B 2 11  ? 267.047 125.479 275.349 1.00 87.61  ? 11  LEU B CD1 1 
ATOM 1503 C CD2 . LEU B 2 11  ? 269.246 126.609 275.131 1.00 88.07  ? 11  LEU B CD2 1 
ATOM 1504 N N   . ARG B 2 12  ? 265.837 129.970 276.572 1.00 85.71  ? 12  ARG B N   1 
ATOM 1505 C CA  . ARG B 2 12  ? 265.784 130.448 277.945 1.00 87.66  ? 12  ARG B CA  1 
ATOM 1506 C C   . ARG B 2 12  ? 264.339 130.494 278.427 1.00 81.88  ? 12  ARG B C   1 
ATOM 1507 O O   . ARG B 2 12  ? 264.057 130.094 279.551 1.00 85.84  ? 12  ARG B O   1 
ATOM 1508 C CB  . ARG B 2 12  ? 266.401 131.841 278.120 1.00 94.47  ? 12  ARG B CB  1 
ATOM 1509 C CG  . ARG B 2 12  ? 266.740 132.209 279.561 1.00 99.99  ? 12  ARG B CG  1 
ATOM 1510 C CD  . ARG B 2 12  ? 266.828 133.708 279.804 1.00 104.12 ? 12  ARG B CD  1 
ATOM 1511 N NE  . ARG B 2 12  ? 267.835 134.326 278.935 1.00 110.85 ? 12  ARG B NE  1 
ATOM 1512 C CZ  . ARG B 2 12  ? 269.165 134.328 279.097 1.00 115.48 ? 12  ARG B CZ  1 
ATOM 1513 N NH1 . ARG B 2 12  ? 269.934 134.790 278.113 1.00 116.08 ? 12  ARG B NH1 1 
ATOM 1514 N NH2 . ARG B 2 12  ? 269.729 133.863 280.210 1.00 114.78 ? 12  ARG B NH2 1 
ATOM 1515 N N   . VAL B 2 13  ? 263.431 130.998 277.594 1.00 78.09  ? 13  VAL B N   1 
ATOM 1516 C CA  . VAL B 2 13  ? 262.044 131.127 278.002 1.00 76.63  ? 13  VAL B CA  1 
ATOM 1517 C C   . VAL B 2 13  ? 261.448 129.746 278.223 1.00 77.77  ? 13  VAL B C   1 
ATOM 1518 O O   . VAL B 2 13  ? 260.764 129.543 279.216 1.00 82.99  ? 13  VAL B O   1 
ATOM 1519 C CB  . VAL B 2 13  ? 261.225 131.941 276.993 1.00 78.40  ? 13  VAL B CB  1 
ATOM 1520 C CG1 . VAL B 2 13  ? 259.725 131.732 277.137 1.00 80.58  ? 13  VAL B CG1 1 
ATOM 1521 C CG2 . VAL B 2 13  ? 261.564 133.421 277.110 1.00 83.99  ? 13  VAL B CG2 1 
ATOM 1522 N N   . ASN B 2 14  ? 261.722 128.802 277.320 1.00 77.62  ? 14  ASN B N   1 
ATOM 1523 C CA  . ASN B 2 14  ? 261.113 127.490 277.404 1.00 75.38  ? 14  ASN B CA  1 
ATOM 1524 C C   . ASN B 2 14  ? 261.698 126.688 278.562 1.00 76.20  ? 14  ASN B C   1 
ATOM 1525 O O   . ASN B 2 14  ? 260.959 125.935 279.191 1.00 81.29  ? 14  ASN B O   1 
ATOM 1526 C CB  . ASN B 2 14  ? 261.155 126.779 276.064 1.00 76.06  ? 14  ASN B CB  1 
ATOM 1527 C CG  . ASN B 2 14  ? 260.066 127.308 275.168 1.00 78.17  ? 14  ASN B CG  1 
ATOM 1528 O OD1 . ASN B 2 14  ? 258.902 126.910 275.282 1.00 77.68  ? 14  ASN B OD1 1 
ATOM 1529 N ND2 . ASN B 2 14  ? 260.420 128.220 274.281 1.00 83.09  ? 14  ASN B ND2 1 
ATOM 1530 N N   . LEU B 2 15  ? 262.978 126.859 278.891 1.00 74.13  ? 15  LEU B N   1 
ATOM 1531 C CA  . LEU B 2 15  ? 263.512 126.171 280.054 1.00 77.04  ? 15  LEU B CA  1 
ATOM 1532 C C   . LEU B 2 15  ? 262.770 126.614 281.312 1.00 81.09  ? 15  LEU B C   1 
ATOM 1533 O O   . LEU B 2 15  ? 262.552 125.798 282.197 1.00 89.13  ? 15  LEU B O   1 
ATOM 1534 C CB  . LEU B 2 15  ? 265.011 126.383 280.221 1.00 75.78  ? 15  LEU B CB  1 
ATOM 1535 C CG  . LEU B 2 15  ? 265.913 125.585 279.279 1.00 77.58  ? 15  LEU B CG  1 
ATOM 1536 C CD1 . LEU B 2 15  ? 267.315 126.153 279.307 1.00 83.14  ? 15  LEU B CD1 1 
ATOM 1537 C CD2 . LEU B 2 15  ? 265.955 124.108 279.619 1.00 81.56  ? 15  LEU B CD2 1 
ATOM 1538 N N   . ARG B 2 16  ? 262.401 127.891 281.409 1.00 82.57  ? 16  ARG B N   1 
ATOM 1539 C CA  . ARG B 2 16  ? 261.678 128.370 282.573 1.00 86.66  ? 16  ARG B CA  1 
ATOM 1540 C C   . ARG B 2 16  ? 260.279 127.762 282.608 1.00 80.58  ? 16  ARG B C   1 
ATOM 1541 O O   . ARG B 2 16  ? 259.816 127.339 283.669 1.00 84.67  ? 16  ARG B O   1 
ATOM 1542 C CB  . ARG B 2 16  ? 261.604 129.899 282.597 1.00 95.65  ? 16  ARG B CB  1 
ATOM 1543 C CG  . ARG B 2 16  ? 262.916 130.559 282.992 1.00 102.42 ? 16  ARG B CG  1 
ATOM 1544 C CD  . ARG B 2 16  ? 262.761 132.066 283.016 1.00 110.93 ? 16  ARG B CD  1 
ATOM 1545 N NE  . ARG B 2 16  ? 264.042 132.703 283.352 1.00 119.81 ? 16  ARG B NE  1 
ATOM 1546 C CZ  . ARG B 2 16  ? 264.628 133.734 282.719 1.00 126.43 ? 16  ARG B CZ  1 
ATOM 1547 N NH1 . ARG B 2 16  ? 265.806 134.166 283.158 1.00 128.17 ? 16  ARG B NH1 1 
ATOM 1548 N NH2 . ARG B 2 16  ? 264.056 134.342 281.675 1.00 126.22 ? 16  ARG B NH2 1 
ATOM 1549 N N   . LEU B 2 17  ? 259.623 127.719 281.449 1.00 77.82  ? 17  LEU B N   1 
ATOM 1550 C CA  . LEU B 2 17  ? 258.292 127.154 281.349 1.00 75.85  ? 17  LEU B CA  1 
ATOM 1551 C C   . LEU B 2 17  ? 258.321 125.678 281.735 1.00 76.37  ? 17  LEU B C   1 
ATOM 1552 O O   . LEU B 2 17  ? 257.443 125.232 282.464 1.00 80.97  ? 17  LEU B O   1 
ATOM 1553 C CB  . LEU B 2 17  ? 257.730 127.364 279.947 1.00 74.04  ? 17  LEU B CB  1 
ATOM 1554 C CG  . LEU B 2 17  ? 257.305 128.796 279.620 1.00 76.01  ? 17  LEU B CG  1 
ATOM 1555 C CD1 . LEU B 2 17  ? 256.868 128.920 278.169 1.00 79.25  ? 17  LEU B CD1 1 
ATOM 1556 C CD2 . LEU B 2 17  ? 256.189 129.298 280.522 1.00 79.21  ? 17  LEU B CD2 1 
ATOM 1557 N N   . VAL B 2 18  ? 259.328 124.929 281.276 1.00 73.87  ? 18  VAL B N   1 
ATOM 1558 C CA  . VAL B 2 18  ? 259.430 123.517 281.611 1.00 74.88  ? 18  VAL B CA  1 
ATOM 1559 C C   . VAL B 2 18  ? 259.507 123.342 283.125 1.00 75.76  ? 18  VAL B C   1 
ATOM 1560 O O   . VAL B 2 18  ? 258.860 122.458 283.671 1.00 79.70  ? 18  VAL B O   1 
ATOM 1561 C CB  . VAL B 2 18  ? 260.613 122.816 280.917 1.00 76.29  ? 18  VAL B CB  1 
ATOM 1562 C CG1 . VAL B 2 18  ? 260.997 121.512 281.598 1.00 75.38  ? 18  VAL B CG1 1 
ATOM 1563 C CG2 . VAL B 2 18  ? 260.332 122.570 279.438 1.00 79.46  ? 18  VAL B CG2 1 
ATOM 1564 N N   . ILE B 2 19  ? 260.286 124.178 283.804 1.00 78.62  ? 19  ILE B N   1 
ATOM 1565 C CA  . ILE B 2 19  ? 260.445 124.047 285.241 1.00 80.95  ? 19  ILE B CA  1 
ATOM 1566 C C   . ILE B 2 19  ? 259.109 124.303 285.935 1.00 79.50  ? 19  ILE B C   1 
ATOM 1567 O O   . ILE B 2 19  ? 258.753 123.562 286.840 1.00 81.98  ? 19  ILE B O   1 
ATOM 1568 C CB  . ILE B 2 19  ? 261.570 124.968 285.741 1.00 82.74  ? 19  ILE B CB  1 
ATOM 1569 C CG1 . ILE B 2 19  ? 262.925 124.381 285.379 1.00 81.84  ? 19  ILE B CG1 1 
ATOM 1570 C CG2 . ILE B 2 19  ? 261.459 125.241 287.243 1.00 88.65  ? 19  ILE B CG2 1 
ATOM 1571 C CD1 . ILE B 2 19  ? 264.082 125.346 285.523 1.00 86.14  ? 19  ILE B CD1 1 
ATOM 1572 N N   . ASN B 2 20  ? 258.372 125.334 285.525 1.00 80.08  ? 20  ASN B N   1 
ATOM 1573 C CA  . ASN B 2 20  ? 257.106 125.640 286.172 1.00 86.01  ? 20  ASN B CA  1 
ATOM 1574 C C   . ASN B 2 20  ? 256.100 124.512 285.973 1.00 84.63  ? 20  ASN B C   1 
ATOM 1575 O O   . ASN B 2 20  ? 255.373 124.156 286.895 1.00 87.27  ? 20  ASN B O   1 
ATOM 1576 C CB  . ASN B 2 20  ? 256.513 126.955 285.690 1.00 91.04  ? 20  ASN B CB  1 
ATOM 1577 C CG  . ASN B 2 20  ? 257.260 128.141 286.250 1.00 98.96  ? 20  ASN B CG  1 
ATOM 1578 O OD1 . ASN B 2 20  ? 258.194 127.975 287.048 1.00 102.92 ? 20  ASN B OD1 1 
ATOM 1579 N ND2 . ASN B 2 20  ? 256.863 129.345 285.854 1.00 103.28 ? 20  ASN B ND2 1 
ATOM 1580 N N   . ARG B 2 21  ? 256.063 123.953 284.769 1.00 81.59  ? 21  ARG B N   1 
ATOM 1581 C CA  . ARG B 2 21  ? 255.119 122.900 284.470 1.00 80.11  ? 21  ARG B CA  1 
ATOM 1582 C C   . ARG B 2 21  ? 255.488 121.623 285.225 1.00 80.02  ? 21  ARG B C   1 
ATOM 1583 O O   . ARG B 2 21  ? 254.602 120.992 285.790 1.00 88.39  ? 21  ARG B O   1 
ATOM 1584 C CB  . ARG B 2 21  ? 255.009 122.777 282.951 1.00 79.67  ? 21  ARG B CB  1 
ATOM 1585 C CG  . ARG B 2 21  ? 254.143 121.599 282.553 1.00 82.23  ? 21  ARG B CG  1 
ATOM 1586 C CD  . ARG B 2 21  ? 253.626 121.725 281.147 1.00 82.59  ? 21  ARG B CD  1 
ATOM 1587 N NE  . ARG B 2 21  ? 252.313 122.368 281.135 1.00 79.83  ? 21  ARG B NE  1 
ATOM 1588 C CZ  . ARG B 2 21  ? 251.925 123.353 280.352 1.00 78.43  ? 21  ARG B CZ  1 
ATOM 1589 N NH1 . ARG B 2 21  ? 250.648 123.670 280.318 1.00 79.55  ? 21  ARG B NH1 1 
ATOM 1590 N NH2 . ARG B 2 21  ? 252.764 123.980 279.558 1.00 78.96  ? 21  ARG B NH2 1 
ATOM 1591 N N   . LEU B 2 22  ? 256.766 121.244 285.273 1.00 77.77  ? 22  LEU B N   1 
ATOM 1592 C CA  . LEU B 2 22  ? 257.167 120.058 286.020 1.00 79.99  ? 22  LEU B CA  1 
ATOM 1593 C C   . LEU B 2 22  ? 256.874 120.219 287.512 1.00 80.63  ? 22  LEU B C   1 
ATOM 1594 O O   . LEU B 2 22  ? 256.526 119.239 288.165 1.00 85.45  ? 22  LEU B O   1 
ATOM 1595 C CB  . LEU B 2 22  ? 258.641 119.714 285.808 1.00 82.38  ? 22  LEU B CB  1 
ATOM 1596 C CG  . LEU B 2 22  ? 259.034 119.223 284.410 1.00 82.21  ? 22  LEU B CG  1 
ATOM 1597 C CD1 . LEU B 2 22  ? 260.547 119.070 284.324 1.00 84.76  ? 22  LEU B CD1 1 
ATOM 1598 C CD2 . LEU B 2 22  ? 258.358 117.932 284.014 1.00 79.70  ? 22  LEU B CD2 1 
ATOM 1599 N N   . LYS B 2 23  ? 257.026 121.425 288.060 1.00 82.44  ? 23  LYS B N   1 
ATOM 1600 C CA  . LYS B 2 23  ? 256.761 121.657 289.470 1.00 86.79  ? 23  LYS B CA  1 
ATOM 1601 C C   . LYS B 2 23  ? 255.277 121.492 289.784 1.00 88.99  ? 23  LYS B C   1 
ATOM 1602 O O   . LYS B 2 23  ? 254.939 121.070 290.891 1.00 97.12  ? 23  LYS B O   1 
ATOM 1603 C CB  . LYS B 2 23  ? 257.272 123.032 289.908 1.00 93.11  ? 23  LYS B CB  1 
ATOM 1604 C CG  . LYS B 2 23  ? 258.795 123.050 290.092 1.00 101.07 ? 23  LYS B CG  1 
ATOM 1605 C CD  . LYS B 2 23  ? 259.448 124.424 290.194 1.00 103.81 ? 23  LYS B CD  1 
ATOM 1606 C CE  . LYS B 2 23  ? 259.142 125.163 291.462 1.00 107.68 ? 23  LYS B CE  1 
ATOM 1607 N NZ  . LYS B 2 23  ? 259.879 126.429 291.508 1.00 110.82 ? 23  LYS B NZ  1 
ATOM 1608 N N   . LEU B 2 24  ? 254.396 121.800 288.828 1.00 85.05  ? 24  LEU B N   1 
ATOM 1609 C CA  . LEU B 2 24  ? 252.979 121.551 289.020 1.00 82.71  ? 24  LEU B CA  1 
ATOM 1610 C C   . LEU B 2 24  ? 252.690 120.066 288.891 1.00 85.46  ? 24  LEU B C   1 
ATOM 1611 O O   . LEU B 2 24  ? 251.917 119.540 289.680 1.00 96.04  ? 24  LEU B O   1 
ATOM 1612 C CB  . LEU B 2 24  ? 252.114 122.330 288.043 1.00 85.79  ? 24  LEU B CB  1 
ATOM 1613 C CG  . LEU B 2 24  ? 251.548 123.647 288.576 1.00 93.22  ? 24  LEU B CG  1 
ATOM 1614 C CD1 . LEU B 2 24  ? 252.621 124.689 288.924 1.00 98.73  ? 24  LEU B CD1 1 
ATOM 1615 C CD2 . LEU B 2 24  ? 250.568 124.196 287.550 1.00 95.51  ? 24  LEU B CD2 1 
ATOM 1616 N N   . LEU B 2 25  ? 253.271 119.393 287.899 1.00 83.33  ? 25  LEU B N   1 
ATOM 1617 C CA  . LEU B 2 25  ? 252.952 117.992 287.688 1.00 85.01  ? 25  LEU B CA  1 
ATOM 1618 C C   . LEU B 2 25  ? 253.445 117.144 288.860 1.00 88.45  ? 25  LEU B C   1 
ATOM 1619 O O   . LEU B 2 25  ? 252.752 116.228 289.276 1.00 95.47  ? 25  LEU B O   1 
ATOM 1620 C CB  . LEU B 2 25  ? 253.499 117.502 286.352 1.00 86.06  ? 25  LEU B CB  1 
ATOM 1621 C CG  . LEU B 2 25  ? 252.831 118.110 285.112 1.00 89.67  ? 25  LEU B CG  1 
ATOM 1622 C CD1 . LEU B 2 25  ? 253.575 117.707 283.842 1.00 90.26  ? 25  LEU B CD1 1 
ATOM 1623 C CD2 . LEU B 2 25  ? 251.352 117.745 284.995 1.00 91.68  ? 25  LEU B CD2 1 
ATOM 1624 N N   . GLU B 2 26  ? 254.605 117.455 289.429 1.00 91.10  ? 26  GLU B N   1 
ATOM 1625 C CA  . GLU B 2 26  ? 255.053 116.736 290.606 1.00 94.12  ? 26  GLU B CA  1 
ATOM 1626 C C   . GLU B 2 26  ? 253.982 116.818 291.691 1.00 89.25  ? 26  GLU B C   1 
ATOM 1627 O O   . GLU B 2 26  ? 253.619 115.798 292.267 1.00 90.98  ? 26  GLU B O   1 
ATOM 1628 C CB  . GLU B 2 26  ? 256.369 117.281 291.161 1.00 103.43 ? 26  GLU B CB  1 
ATOM 1629 C CG  . GLU B 2 26  ? 257.587 117.056 290.262 1.00 110.60 ? 26  GLU B CG  1 
ATOM 1630 C CD  . GLU B 2 26  ? 258.703 118.084 290.490 1.00 120.11 ? 26  GLU B CD  1 
ATOM 1631 O OE1 . GLU B 2 26  ? 258.740 118.700 291.592 1.00 122.08 ? 26  GLU B OE1 1 
ATOM 1632 O OE2 . GLU B 2 26  ? 259.517 118.321 289.554 1.00 120.54 ? 26  GLU B OE2 1 
ATOM 1633 N N   . LYS B 2 27  ? 253.490 118.026 291.975 1.00 88.37  ? 27  LYS B N   1 
ATOM 1634 C CA  . LYS B 2 27  ? 252.530 118.216 293.050 1.00 93.09  ? 27  LYS B CA  1 
ATOM 1635 C C   . LYS B 2 27  ? 251.246 117.452 292.767 1.00 92.69  ? 27  LYS B C   1 
ATOM 1636 O O   . LYS B 2 27  ? 250.728 116.769 293.644 1.00 99.29  ? 27  LYS B O   1 
ATOM 1637 C CB  . LYS B 2 27  ? 252.131 119.679 293.245 1.00 97.03  ? 27  LYS B CB  1 
ATOM 1638 C CG  . LYS B 2 27  ? 253.109 120.484 294.060 1.00 104.26 ? 27  LYS B CG  1 
ATOM 1639 C CD  . LYS B 2 27  ? 252.719 121.955 294.173 1.00 109.56 ? 27  LYS B CD  1 
ATOM 1640 C CE  . LYS B 2 27  ? 253.727 122.775 294.945 1.00 116.36 ? 27  LYS B CE  1 
ATOM 1641 N NZ  . LYS B 2 27  ? 255.082 122.815 294.363 1.00 118.53 ? 27  LYS B NZ  1 
ATOM 1642 N N   . LYS B 2 28  ? 250.740 117.591 291.545 1.00 87.96  ? 28  LYS B N   1 
ATOM 1643 C CA  . LYS B 2 28  ? 249.475 117.003 291.170 1.00 83.65  ? 28  LYS B CA  1 
ATOM 1644 C C   . LYS B 2 28  ? 249.572 115.485 291.209 1.00 80.30  ? 28  LYS B C   1 
ATOM 1645 O O   . LYS B 2 28  ? 248.689 114.845 291.754 1.00 88.92  ? 28  LYS B O   1 
ATOM 1646 C CB  . LYS B 2 28  ? 249.105 117.562 289.800 1.00 87.00  ? 28  LYS B CB  1 
ATOM 1647 C CG  . LYS B 2 28  ? 247.828 116.999 289.231 1.00 89.98  ? 28  LYS B CG  1 
ATOM 1648 C CD  . LYS B 2 28  ? 247.345 117.731 287.992 1.00 90.83  ? 28  LYS B CD  1 
ATOM 1649 C CE  . LYS B 2 28  ? 246.175 117.049 287.379 1.00 90.38  ? 28  LYS B CE  1 
ATOM 1650 N NZ  . LYS B 2 28  ? 245.493 117.916 286.416 1.00 90.54  ? 28  LYS B NZ  1 
ATOM 1651 N N   . LYS B 2 29  ? 250.639 114.914 290.657 1.00 79.50  ? 29  LYS B N   1 
ATOM 1652 C CA  . LYS B 2 29  ? 250.776 113.470 290.600 1.00 81.56  ? 29  LYS B CA  1 
ATOM 1653 C C   . LYS B 2 29  ? 251.068 112.877 291.973 1.00 83.51  ? 29  LYS B C   1 
ATOM 1654 O O   . LYS B 2 29  ? 250.791 111.702 292.199 1.00 89.11  ? 29  LYS B O   1 
ATOM 1655 C CB  . LYS B 2 29  ? 251.872 113.053 289.622 1.00 84.43  ? 29  LYS B CB  1 
ATOM 1656 C CG  . LYS B 2 29  ? 251.506 113.298 288.176 1.00 88.18  ? 29  LYS B CG  1 
ATOM 1657 C CD  . LYS B 2 29  ? 252.566 112.821 287.196 1.00 90.49  ? 29  LYS B CD  1 
ATOM 1658 C CE  . LYS B 2 29  ? 252.169 113.118 285.792 1.00 93.20  ? 29  LYS B CE  1 
ATOM 1659 N NZ  . LYS B 2 29  ? 251.026 112.316 285.340 1.00 96.44  ? 29  LYS B NZ  1 
ATOM 1660 N N   . THR B 2 30  ? 251.645 113.659 292.879 1.00 85.91  ? 30  THR B N   1 
ATOM 1661 C CA  . THR B 2 30  ? 251.845 113.193 294.240 1.00 89.24  ? 30  THR B CA  1 
ATOM 1662 C C   . THR B 2 30  ? 250.494 113.083 294.941 1.00 89.36  ? 30  THR B C   1 
ATOM 1663 O O   . THR B 2 30  ? 250.265 112.128 295.675 1.00 93.85  ? 30  THR B O   1 
ATOM 1664 C CB  . THR B 2 30  ? 252.797 114.134 294.976 1.00 92.98  ? 30  THR B CB  1 
ATOM 1665 O OG1 . THR B 2 30  ? 254.058 113.970 294.333 1.00 91.95  ? 30  THR B OG1 1 
ATOM 1666 C CG2 . THR B 2 30  ? 252.950 113.802 296.451 1.00 96.74  ? 30  THR B CG2 1 
ATOM 1667 N N   . GLU B 2 31  ? 249.616 114.063 294.730 1.00 90.34  ? 31  GLU B N   1 
ATOM 1668 C CA  . GLU B 2 31  ? 248.309 114.061 295.360 1.00 92.86  ? 31  GLU B CA  1 
ATOM 1669 C C   . GLU B 2 31  ? 247.446 112.946 294.782 1.00 92.24  ? 31  GLU B C   1 
ATOM 1670 O O   . GLU B 2 31  ? 246.671 112.349 295.517 1.00 98.93  ? 31  GLU B O   1 
ATOM 1671 C CB  . GLU B 2 31  ? 247.621 115.414 295.184 1.00 100.32 ? 31  GLU B CB  1 
ATOM 1672 C CG  . GLU B 2 31  ? 246.205 115.466 295.754 1.00 108.91 ? 31  GLU B CG  1 
ATOM 1673 C CD  . GLU B 2 31  ? 246.043 115.186 297.248 1.00 116.78 ? 31  GLU B CD  1 
ATOM 1674 O OE1 . GLU B 2 31  ? 246.973 115.488 298.052 1.00 121.60 ? 31  GLU B OE1 1 
ATOM 1675 O OE2 . GLU B 2 31  ? 244.968 114.639 297.610 1.00 117.39 ? 31  GLU B OE2 1 
ATOM 1676 N N   . LEU B 2 32  ? 247.553 112.684 293.477 1.00 89.34  ? 32  LEU B N   1 
ATOM 1677 C CA  . LEU B 2 32  ? 246.761 111.640 292.856 1.00 87.53  ? 32  LEU B CA  1 
ATOM 1678 C C   . LEU B 2 32  ? 247.212 110.265 293.340 1.00 90.36  ? 32  LEU B C   1 
ATOM 1679 O O   . LEU B 2 32  ? 246.400 109.342 293.339 1.00 96.96  ? 32  LEU B O   1 
ATOM 1680 C CB  . LEU B 2 32  ? 246.819 111.745 291.337 1.00 88.97  ? 32  LEU B CB  1 
ATOM 1681 C CG  . LEU B 2 32  ? 246.071 112.934 290.720 1.00 90.72  ? 32  LEU B CG  1 
ATOM 1682 C CD1 . LEU B 2 32  ? 246.408 113.051 289.240 1.00 92.92  ? 32  LEU B CD1 1 
ATOM 1683 C CD2 . LEU B 2 32  ? 244.558 112.874 290.895 1.00 92.14  ? 32  LEU B CD2 1 
ATOM 1684 N N   . ALA B 2 33  ? 248.474 110.121 293.753 1.00 89.98  ? 33  ALA B N   1 
ATOM 1685 C CA  . ALA B 2 33  ? 248.941 108.871 294.337 1.00 94.22  ? 33  ALA B CA  1 
ATOM 1686 C C   . ALA B 2 33  ? 248.340 108.644 295.724 1.00 94.65  ? 33  ALA B C   1 
ATOM 1687 O O   . ALA B 2 33  ? 248.124 107.503 296.115 1.00 98.02  ? 33  ALA B O   1 
ATOM 1688 C CB  . ALA B 2 33  ? 250.453 108.847 294.399 1.00 99.29  ? 33  ALA B CB  1 
ATOM 1689 N N   . GLN B 2 34  ? 248.095 109.711 296.485 1.00 98.92  ? 34  GLN B N   1 
ATOM 1690 C CA  . GLN B 2 34  ? 247.439 109.575 297.776 1.00 104.08 ? 34  GLN B CA  1 
ATOM 1691 C C   . GLN B 2 34  ? 246.044 108.985 297.582 1.00 101.80 ? 34  GLN B C   1 
ATOM 1692 O O   . GLN B 2 34  ? 245.654 108.072 298.301 1.00 104.97 ? 34  GLN B O   1 
ATOM 1693 C CB  . GLN B 2 34  ? 247.336 110.912 298.516 1.00 109.59 ? 34  GLN B CB  1 
ATOM 1694 C CG  . GLN B 2 34  ? 248.662 111.454 299.036 1.00 114.65 ? 34  GLN B CG  1 
ATOM 1695 C CD  . GLN B 2 34  ? 249.084 110.818 300.345 1.00 123.03 ? 34  GLN B CD  1 
ATOM 1696 O OE1 . GLN B 2 34  ? 249.148 109.588 300.478 1.00 124.10 ? 34  GLN B OE1 1 
ATOM 1697 N NE2 . GLN B 2 34  ? 249.374 111.653 301.337 1.00 127.55 ? 34  GLN B NE2 1 
ATOM 1698 N N   . LYS B 2 35  ? 245.300 109.529 296.618 1.00 99.89  ? 35  LYS B N   1 
ATOM 1699 C CA  . LYS B 2 35  ? 243.958 109.067 296.318 1.00 101.88 ? 35  LYS B CA  1 
ATOM 1700 C C   . LYS B 2 35  ? 243.985 107.633 295.791 1.00 101.00 ? 35  LYS B C   1 
ATOM 1701 O O   . LYS B 2 35  ? 243.052 106.876 296.045 1.00 103.92 ? 35  LYS B O   1 
ATOM 1702 C CB  . LYS B 2 35  ? 243.308 110.041 295.328 1.00 104.07 ? 35  LYS B CB  1 
ATOM 1703 C CG  . LYS B 2 35  ? 242.810 111.354 295.936 1.00 108.34 ? 35  LYS B CG  1 
ATOM 1704 C CD  . LYS B 2 35  ? 242.721 112.504 294.933 1.00 112.34 ? 35  LYS B CD  1 
ATOM 1705 C CE  . LYS B 2 35  ? 241.897 113.709 295.333 1.00 113.65 ? 35  LYS B CE  1 
ATOM 1706 N NZ  . LYS B 2 35  ? 242.361 114.409 296.537 1.00 113.88 ? 35  LYS B NZ  1 
ATOM 1707 N N   . ALA B 2 36  ? 245.040 107.270 295.054 1.00 100.66 ? 36  ALA B N   1 
ATOM 1708 C CA  . ALA B 2 36  ? 245.120 105.968 294.410 1.00 101.02 ? 36  ALA B CA  1 
ATOM 1709 C C   . ALA B 2 36  ? 245.477 104.875 295.406 1.00 102.83 ? 36  ALA B C   1 
ATOM 1710 O O   . ALA B 2 36  ? 245.087 103.727 295.200 1.00 108.76 ? 36  ALA B O   1 
ATOM 1711 C CB  . ALA B 2 36  ? 246.127 105.989 293.290 1.00 103.09 ? 36  ALA B CB  1 
ATOM 1712 N N   . ARG B 2 37  ? 246.247 105.202 296.447 1.00 106.43 ? 37  ARG B N   1 
ATOM 1713 C CA  . ARG B 2 37  ? 246.660 104.198 297.417 1.00 109.53 ? 37  ARG B CA  1 
ATOM 1714 C C   . ARG B 2 37  ? 245.478 103.756 298.273 1.00 109.31 ? 37  ARG B C   1 
ATOM 1715 O O   . ARG B 2 37  ? 245.443 102.605 298.701 1.00 111.09 ? 37  ARG B O   1 
ATOM 1716 C CB  . ARG B 2 37  ? 247.840 104.686 298.265 1.00 112.85 ? 37  ARG B CB  1 
ATOM 1717 C CG  . ARG B 2 37  ? 249.140 104.655 297.473 1.00 115.25 ? 37  ARG B CG  1 
ATOM 1718 C CD  . ARG B 2 37  ? 250.378 104.951 298.284 1.00 118.78 ? 37  ARG B CD  1 
ATOM 1719 N NE  . ARG B 2 37  ? 250.374 106.288 298.889 1.00 122.54 ? 37  ARG B NE  1 
ATOM 1720 C CZ  . ARG B 2 37  ? 251.331 107.212 298.793 1.00 125.52 ? 37  ARG B CZ  1 
ATOM 1721 N NH1 . ARG B 2 37  ? 251.250 108.298 299.547 1.00 124.31 ? 37  ARG B NH1 1 
ATOM 1722 N NH2 . ARG B 2 37  ? 252.384 107.043 298.000 1.00 126.65 ? 37  ARG B NH2 1 
ATOM 1723 N N   . LYS B 2 38  ? 244.511 104.651 298.505 1.00 110.13 ? 38  LYS B N   1 
ATOM 1724 C CA  . LYS B 2 38  ? 243.307 104.282 299.228 1.00 112.68 ? 38  LYS B CA  1 
ATOM 1725 C C   . LYS B 2 38  ? 242.495 103.290 298.395 1.00 112.44 ? 38  LYS B C   1 
ATOM 1726 O O   . LYS B 2 38  ? 241.923 102.355 298.947 1.00 115.95 ? 38  LYS B O   1 
ATOM 1727 C CB  . LYS B 2 38  ? 242.473 105.506 299.622 1.00 117.27 ? 38  LYS B CB  1 
ATOM 1728 C CG  . LYS B 2 38  ? 241.527 105.239 300.794 1.00 124.07 ? 38  LYS B CG  1 
ATOM 1729 C CD  . LYS B 2 38  ? 240.574 106.366 301.184 1.00 127.37 ? 38  LYS B CD  1 
ATOM 1730 C CE  . LYS B 2 38  ? 239.412 106.509 300.230 1.00 130.59 ? 38  LYS B CE  1 
ATOM 1731 N NZ  . LYS B 2 38  ? 238.406 107.474 300.689 1.00 130.67 ? 38  LYS B NZ  1 
ATOM 1732 N N   . GLU B 2 39  ? 242.460 103.481 297.074 1.00 112.12 ? 39  GLU B N   1 
ATOM 1733 C CA  . GLU B 2 39  ? 241.774 102.562 296.177 1.00 113.49 ? 39  GLU B CA  1 
ATOM 1734 C C   . GLU B 2 39  ? 242.395 101.165 296.261 1.00 111.63 ? 39  GLU B C   1 
ATOM 1735 O O   . GLU B 2 39  ? 241.672 100.180 296.142 1.00 115.73 ? 39  GLU B O   1 
ATOM 1736 C CB  . GLU B 2 39  ? 241.789 103.116 294.750 1.00 117.88 ? 39  GLU B CB  1 
ATOM 1737 C CG  . GLU B 2 39  ? 240.800 102.457 293.788 1.00 122.95 ? 39  GLU B CG  1 
ATOM 1738 C CD  . GLU B 2 39  ? 241.061 102.706 292.303 1.00 128.08 ? 39  GLU B CD  1 
ATOM 1739 O OE1 . GLU B 2 39  ? 241.464 103.839 291.949 1.00 132.02 ? 39  GLU B OE1 1 
ATOM 1740 O OE2 . GLU B 2 39  ? 240.818 101.788 291.478 1.00 129.91 ? 39  GLU B OE2 1 
ATOM 1741 N N   . ILE B 2 40  ? 243.715 101.066 296.459 1.00 111.11 ? 40  ILE B N   1 
ATOM 1742 C CA  . ILE B 2 40  ? 244.368 99.769  296.598 1.00 113.53 ? 40  ILE B CA  1 
ATOM 1743 C C   . ILE B 2 40  ? 243.870 99.097  297.875 1.00 117.58 ? 40  ILE B C   1 
ATOM 1744 O O   . ILE B 2 40  ? 243.584 97.902  297.870 1.00 121.40 ? 40  ILE B O   1 
ATOM 1745 C CB  . ILE B 2 40  ? 245.908 99.880  296.610 1.00 114.81 ? 40  ILE B CB  1 
ATOM 1746 C CG1 . ILE B 2 40  ? 246.477 100.545 295.345 1.00 113.98 ? 40  ILE B CG1 1 
ATOM 1747 C CG2 . ILE B 2 40  ? 246.567 98.520  296.870 1.00 113.50 ? 40  ILE B CG2 1 
ATOM 1748 C CD1 . ILE B 2 40  ? 246.140 99.850  294.041 1.00 114.79 ? 40  ILE B CD1 1 
ATOM 1749 N N   . ALA B 2 41  ? 243.789 99.860  298.970 1.00 118.61 ? 41  ALA B N   1 
ATOM 1750 C CA  . ALA B 2 41  ? 243.307 99.322  300.233 1.00 120.24 ? 41  ALA B CA  1 
ATOM 1751 C C   . ALA B 2 41  ? 241.872 98.803  300.090 1.00 120.64 ? 41  ALA B C   1 
ATOM 1752 O O   . ALA B 2 41  ? 241.533 97.781  300.681 1.00 121.23 ? 41  ALA B O   1 
ATOM 1753 C CB  . ALA B 2 41  ? 243.428 100.376 301.313 1.00 120.88 ? 41  ALA B CB  1 
ATOM 1754 N N   . ASP B 2 42  ? 241.045 99.487  299.289 1.00 121.32 ? 42  ASP B N   1 
ATOM 1755 C CA  . ASP B 2 42  ? 239.673 99.067  299.049 1.00 124.72 ? 42  ASP B CA  1 
ATOM 1756 C C   . ASP B 2 42  ? 239.622 97.714  298.340 1.00 122.49 ? 42  ASP B C   1 
ATOM 1757 O O   . ASP B 2 42  ? 238.767 96.897  298.675 1.00 123.62 ? 42  ASP B O   1 
ATOM 1758 C CB  . ASP B 2 42  ? 238.892 100.122 298.279 1.00 129.96 ? 42  ASP B CB  1 
ATOM 1759 C CG  . ASP B 2 42  ? 238.587 101.402 299.047 1.00 136.62 ? 42  ASP B CG  1 
ATOM 1760 O OD1 . ASP B 2 42  ? 238.780 101.403 300.285 1.00 138.96 ? 42  ASP B OD1 1 
ATOM 1761 O OD2 . ASP B 2 42  ? 238.174 102.398 298.397 1.00 140.63 ? 42  ASP B OD2 1 
ATOM 1762 N N   . TYR B 2 43  ? 240.502 97.483  297.356 1.00 119.57 ? 43  TYR B N   1 
ATOM 1763 C CA  . TYR B 2 43  ? 240.538 96.198  296.674 1.00 119.73 ? 43  TYR B CA  1 
ATOM 1764 C C   . TYR B 2 43  ? 241.032 95.111  297.623 1.00 121.55 ? 43  TYR B C   1 
ATOM 1765 O O   . TYR B 2 43  ? 240.570 93.974  297.531 1.00 125.89 ? 43  TYR B O   1 
ATOM 1766 C CB  . TYR B 2 43  ? 241.412 96.122  295.420 1.00 119.84 ? 43  TYR B CB  1 
ATOM 1767 C CG  . TYR B 2 43  ? 240.899 96.987  294.279 1.00 120.91 ? 43  TYR B CG  1 
ATOM 1768 C CD1 . TYR B 2 43  ? 239.746 96.657  293.573 1.00 121.78 ? 43  TYR B CD1 1 
ATOM 1769 C CD2 . TYR B 2 43  ? 241.575 98.138  293.908 1.00 121.27 ? 43  TYR B CD2 1 
ATOM 1770 C CE1 . TYR B 2 43  ? 239.277 97.455  292.543 1.00 121.47 ? 43  TYR B CE1 1 
ATOM 1771 C CE2 . TYR B 2 43  ? 241.121 98.938  292.876 1.00 121.18 ? 43  TYR B CE2 1 
ATOM 1772 C CZ  . TYR B 2 43  ? 239.968 98.600  292.191 1.00 120.98 ? 43  TYR B CZ  1 
ATOM 1773 O OH  . TYR B 2 43  ? 239.512 99.389  291.171 1.00 120.18 ? 43  TYR B OH  1 
ATOM 1774 N N   . LEU B 2 44  ? 241.981 95.441  298.503 1.00 121.50 ? 44  LEU B N   1 
ATOM 1775 C CA  . LEU B 2 44  ? 242.501 94.462  299.445 1.00 122.99 ? 44  LEU B CA  1 
ATOM 1776 C C   . LEU B 2 44  ? 241.439 94.089  300.480 1.00 124.58 ? 44  LEU B C   1 
ATOM 1777 O O   . LEU B 2 44  ? 241.329 92.918  300.842 1.00 126.55 ? 44  LEU B O   1 
ATOM 1778 C CB  . LEU B 2 44  ? 243.771 94.996  300.105 1.00 122.90 ? 44  LEU B CB  1 
ATOM 1779 C CG  . LEU B 2 44  ? 245.024 95.044  299.223 1.00 122.42 ? 44  LEU B CG  1 
ATOM 1780 C CD1 . LEU B 2 44  ? 246.148 95.724  299.990 1.00 123.43 ? 44  LEU B CD1 1 
ATOM 1781 C CD2 . LEU B 2 44  ? 245.462 93.666  298.732 1.00 121.62 ? 44  LEU B CD2 1 
ATOM 1782 N N   . ALA B 2 45  ? 240.663 95.076  300.947 1.00 124.92 ? 45  ALA B N   1 
ATOM 1783 C CA  . ALA B 2 45  ? 239.572 94.827  301.880 1.00 127.28 ? 45  ALA B CA  1 
ATOM 1784 C C   . ALA B 2 45  ? 238.518 93.914  301.250 1.00 129.43 ? 45  ALA B C   1 
ATOM 1785 O O   . ALA B 2 45  ? 237.946 93.070  301.939 1.00 132.79 ? 45  ALA B O   1 
ATOM 1786 C CB  . ALA B 2 45  ? 238.967 96.140  302.336 1.00 128.29 ? 45  ALA B CB  1 
ATOM 1787 N N   . ALA B 2 46  ? 238.281 94.081  299.939 1.00 128.29 ? 46  ALA B N   1 
ATOM 1788 C CA  . ALA B 2 46  ? 237.325 93.275  299.189 1.00 127.29 ? 46  ALA B CA  1 
ATOM 1789 C C   . ALA B 2 46  ? 237.911 91.916  298.798 1.00 125.86 ? 46  ALA B C   1 
ATOM 1790 O O   . ALA B 2 46  ? 237.214 91.096  298.198 1.00 126.91 ? 46  ALA B O   1 
ATOM 1791 C CB  . ALA B 2 46  ? 236.876 94.037  297.957 1.00 128.14 ? 46  ALA B CB  1 
ATOM 1792 N N   . GLY B 2 47  ? 239.197 91.690  299.100 1.00 126.24 ? 47  GLY B N   1 
ATOM 1793 C CA  . GLY B 2 47  ? 239.853 90.419  298.832 1.00 128.91 ? 47  GLY B CA  1 
ATOM 1794 C C   . GLY B 2 47  ? 240.219 90.236  297.356 1.00 130.49 ? 47  GLY B C   1 
ATOM 1795 O O   . GLY B 2 47  ? 240.537 89.120  296.942 1.00 130.50 ? 47  GLY B O   1 
ATOM 1796 N N   . LYS B 2 48  ? 240.200 91.332  296.581 1.00 130.49 ? 48  LYS B N   1 
ATOM 1797 C CA  . LYS B 2 48  ? 240.429 91.291  295.143 1.00 129.95 ? 48  LYS B CA  1 
ATOM 1798 C C   . LYS B 2 48  ? 241.911 91.534  294.857 1.00 129.21 ? 48  LYS B C   1 
ATOM 1799 O O   . LYS B 2 48  ? 242.264 92.441  294.106 1.00 131.25 ? 48  LYS B O   1 
ATOM 1800 C CB  . LYS B 2 48  ? 239.523 92.324  294.460 1.00 131.16 ? 48  LYS B CB  1 
ATOM 1801 C CG  . LYS B 2 48  ? 238.028 92.045  294.562 1.00 133.20 ? 48  LYS B CG  1 
ATOM 1802 C CD  . LYS B 2 48  ? 237.152 93.077  293.857 1.00 134.91 ? 48  LYS B CD  1 
ATOM 1803 C CE  . LYS B 2 48  ? 235.691 92.738  293.901 1.00 137.37 ? 48  LYS B CE  1 
ATOM 1804 N NZ  . LYS B 2 48  ? 234.843 93.757  293.271 1.00 139.02 ? 48  LYS B NZ  1 
ATOM 1805 N N   . ASP B 2 49  ? 242.766 90.684  295.436 1.00 128.54 ? 49  ASP B N   1 
ATOM 1806 C CA  . ASP B 2 49  ? 244.198 90.927  295.511 1.00 129.71 ? 49  ASP B CA  1 
ATOM 1807 C C   . ASP B 2 49  ? 244.847 90.913  294.128 1.00 126.78 ? 49  ASP B C   1 
ATOM 1808 O O   . ASP B 2 49  ? 245.822 91.626  293.905 1.00 127.61 ? 49  ASP B O   1 
ATOM 1809 C CB  . ASP B 2 49  ? 244.875 89.935  296.444 1.00 134.08 ? 49  ASP B CB  1 
ATOM 1810 C CG  . ASP B 2 49  ? 244.919 88.495  295.952 1.00 139.95 ? 49  ASP B CG  1 
ATOM 1811 O OD1 . ASP B 2 49  ? 243.902 88.033  295.382 1.00 143.91 ? 49  ASP B OD1 1 
ATOM 1812 O OD2 . ASP B 2 49  ? 245.963 87.836  296.162 1.00 142.87 ? 49  ASP B OD2 1 
ATOM 1813 N N   . GLU B 2 50  ? 244.324 90.102  293.206 1.00 126.48 ? 50  GLU B N   1 
ATOM 1814 C CA  . GLU B 2 50  ? 244.940 89.965  291.897 1.00 127.74 ? 50  GLU B CA  1 
ATOM 1815 C C   . GLU B 2 50  ? 244.784 91.258  291.097 1.00 122.29 ? 50  GLU B C   1 
ATOM 1816 O O   . GLU B 2 50  ? 245.655 91.583  290.297 1.00 121.53 ? 50  GLU B O   1 
ATOM 1817 C CB  . GLU B 2 50  ? 244.371 88.737  291.181 1.00 134.60 ? 50  GLU B CB  1 
ATOM 1818 C CG  . GLU B 2 50  ? 245.082 88.386  289.874 1.00 140.69 ? 50  GLU B CG  1 
ATOM 1819 C CD  . GLU B 2 50  ? 246.596 88.195  289.938 1.00 148.82 ? 50  GLU B CD  1 
ATOM 1820 O OE1 . GLU B 2 50  ? 247.152 87.923  291.036 1.00 150.12 ? 50  GLU B OE1 1 
ATOM 1821 O OE2 . GLU B 2 50  ? 247.232 88.346  288.860 1.00 152.85 ? 50  GLU B OE2 1 
ATOM 1822 N N   . ARG B 2 51  ? 243.685 91.990  291.304 1.00 119.69 ? 51  ARG B N   1 
ATOM 1823 C CA  . ARG B 2 51  ? 243.528 93.281  290.659 1.00 119.01 ? 51  ARG B CA  1 
ATOM 1824 C C   . ARG B 2 51  ? 244.343 94.334  291.404 1.00 116.52 ? 51  ARG B C   1 
ATOM 1825 O O   . ARG B 2 51  ? 244.876 95.246  290.781 1.00 117.76 ? 51  ARG B O   1 
ATOM 1826 C CB  . ARG B 2 51  ? 242.074 93.745  290.543 1.00 122.50 ? 51  ARG B CB  1 
ATOM 1827 C CG  . ARG B 2 51  ? 242.004 94.901  289.556 1.00 124.34 ? 51  ARG B CG  1 
ATOM 1828 C CD  . ARG B 2 51  ? 240.633 95.429  289.281 1.00 124.93 ? 51  ARG B CD  1 
ATOM 1829 N NE  . ARG B 2 51  ? 240.789 96.534  288.331 1.00 124.56 ? 51  ARG B NE  1 
ATOM 1830 C CZ  . ARG B 2 51  ? 239.968 97.574  288.208 1.00 130.06 ? 51  ARG B CZ  1 
ATOM 1831 N NH1 . ARG B 2 51  ? 240.296 98.562  287.384 1.00 129.17 ? 51  ARG B NH1 1 
ATOM 1832 N NH2 . ARG B 2 51  ? 238.823 97.637  288.894 1.00 132.79 ? 51  ARG B NH2 1 
ATOM 1833 N N   . ALA B 2 52  ? 244.444 94.210  292.728 1.00 115.11 ? 52  ALA B N   1 
ATOM 1834 C CA  . ALA B 2 52  ? 245.257 95.130  293.507 1.00 113.02 ? 52  ALA B CA  1 
ATOM 1835 C C   . ALA B 2 52  ? 246.699 95.139  292.993 1.00 111.32 ? 52  ALA B C   1 
ATOM 1836 O O   . ALA B 2 52  ? 247.306 96.203  292.937 1.00 112.40 ? 52  ALA B O   1 
ATOM 1837 C CB  . ALA B 2 52  ? 245.179 94.783  294.978 1.00 114.18 ? 52  ALA B CB  1 
ATOM 1838 N N   . ARG B 2 53  ? 247.239 93.978  292.597 1.00 110.74 ? 53  ARG B N   1 
ATOM 1839 C CA  . ARG B 2 53  ? 248.574 93.905  292.019 1.00 110.80 ? 53  ARG B CA  1 
ATOM 1840 C C   . ARG B 2 53  ? 248.674 94.774  290.766 1.00 109.55 ? 53  ARG B C   1 
ATOM 1841 O O   . ARG B 2 53  ? 249.634 95.521  290.620 1.00 113.18 ? 53  ARG B O   1 
ATOM 1842 C CB  . ARG B 2 53  ? 248.987 92.470  291.674 1.00 114.78 ? 53  ARG B CB  1 
ATOM 1843 C CG  . ARG B 2 53  ? 249.304 91.627  292.899 1.00 118.06 ? 53  ARG B CG  1 
ATOM 1844 C CD  . ARG B 2 53  ? 249.593 90.165  292.618 1.00 122.07 ? 53  ARG B CD  1 
ATOM 1845 N NE  . ARG B 2 53  ? 249.636 89.471  293.911 1.00 125.70 ? 53  ARG B NE  1 
ATOM 1846 C CZ  . ARG B 2 53  ? 248.678 88.715  294.457 1.00 128.78 ? 53  ARG B CZ  1 
ATOM 1847 N NH1 . ARG B 2 53  ? 248.759 88.397  295.740 1.00 129.38 ? 53  ARG B NH1 1 
ATOM 1848 N NH2 . ARG B 2 53  ? 247.615 88.328  293.764 1.00 129.92 ? 53  ARG B NH2 1 
ATOM 1849 N N   . ILE B 2 54  ? 247.697 94.681  289.861 1.00 108.51 ? 54  ILE B N   1 
ATOM 1850 C CA  . ILE B 2 54  ? 247.761 95.403  288.597 1.00 107.78 ? 54  ILE B CA  1 
ATOM 1851 C C   . ILE B 2 54  ? 247.524 96.895  288.822 1.00 105.82 ? 54  ILE B C   1 
ATOM 1852 O O   . ILE B 2 54  ? 248.095 97.709  288.107 1.00 109.26 ? 54  ILE B O   1 
ATOM 1853 C CB  . ILE B 2 54  ? 246.785 94.778  287.582 1.00 111.42 ? 54  ILE B CB  1 
ATOM 1854 C CG1 . ILE B 2 54  ? 247.391 93.475  287.039 1.00 114.40 ? 54  ILE B CG1 1 
ATOM 1855 C CG2 . ILE B 2 54  ? 246.394 95.737  286.453 1.00 110.53 ? 54  ILE B CG2 1 
ATOM 1856 C CD1 . ILE B 2 54  ? 246.385 92.489  286.482 1.00 116.76 ? 54  ILE B CD1 1 
ATOM 1857 N N   . ARG B 2 55  ? 246.705 97.268  289.806 1.00 105.55 ? 55  ARG B N   1 
ATOM 1858 C CA  . ARG B 2 55  ? 246.505 98.677  290.110 1.00 105.65 ? 55  ARG B CA  1 
ATOM 1859 C C   . ARG B 2 55  ? 247.750 99.266  290.773 1.00 104.89 ? 55  ARG B C   1 
ATOM 1860 O O   . ARG B 2 55  ? 247.967 100.473 290.688 1.00 105.44 ? 55  ARG B O   1 
ATOM 1861 C CB  . ARG B 2 55  ? 245.255 98.905  290.969 1.00 106.47 ? 55  ARG B CB  1 
ATOM 1862 C CG  . ARG B 2 55  ? 243.924 98.688  290.270 1.00 109.01 ? 55  ARG B CG  1 
ATOM 1863 C CD  . ARG B 2 55  ? 243.584 99.703  289.202 1.00 111.04 ? 55  ARG B CD  1 
ATOM 1864 N NE  . ARG B 2 55  ? 243.342 101.037 289.752 1.00 116.50 ? 55  ARG B NE  1 
ATOM 1865 C CZ  . ARG B 2 55  ? 243.576 102.177 289.113 1.00 122.64 ? 55  ARG B CZ  1 
ATOM 1866 N NH1 . ARG B 2 55  ? 243.440 103.328 289.759 1.00 126.02 ? 55  ARG B NH1 1 
ATOM 1867 N NH2 . ARG B 2 55  ? 243.954 102.179 287.842 1.00 121.24 ? 55  ARG B NH2 1 
ATOM 1868 N N   . VAL B 2 56  ? 248.558 98.436  291.441 1.00 105.32 ? 56  VAL B N   1 
ATOM 1869 C CA  . VAL B 2 56  ? 249.783 98.912  292.071 1.00 106.19 ? 56  VAL B CA  1 
ATOM 1870 C C   . VAL B 2 56  ? 250.834 99.231  291.006 1.00 106.66 ? 56  VAL B C   1 
ATOM 1871 O O   . VAL B 2 56  ? 251.609 100.165 291.187 1.00 110.28 ? 56  VAL B O   1 
ATOM 1872 C CB  . VAL B 2 56  ? 250.294 97.926  293.144 1.00 106.83 ? 56  VAL B CB  1 
ATOM 1873 C CG1 . VAL B 2 56  ? 251.637 98.322  293.746 1.00 107.58 ? 56  VAL B CG1 1 
ATOM 1874 C CG2 . VAL B 2 56  ? 249.257 97.737  294.246 1.00 108.18 ? 56  VAL B CG2 1 
ATOM 1875 N N   . GLU B 2 57  ? 250.850 98.502  289.885 1.00 106.57 ? 57  GLU B N   1 
ATOM 1876 C CA  . GLU B 2 57  ? 251.794 98.801  288.817 1.00 107.46 ? 57  GLU B CA  1 
ATOM 1877 C C   . GLU B 2 57  ? 251.583 100.214 288.274 1.00 105.90 ? 57  GLU B C   1 
ATOM 1878 O O   . GLU B 2 57  ? 252.537 100.850 287.847 1.00 106.93 ? 57  GLU B O   1 
ATOM 1879 C CB  . GLU B 2 57  ? 251.709 97.831  287.640 1.00 110.66 ? 57  GLU B CB  1 
ATOM 1880 C CG  . GLU B 2 57  ? 252.261 96.439  287.933 1.00 114.69 ? 57  GLU B CG  1 
ATOM 1881 C CD  . GLU B 2 57  ? 252.554 95.617  286.684 1.00 120.08 ? 57  GLU B CD  1 
ATOM 1882 O OE1 . GLU B 2 57  ? 252.153 96.019  285.564 1.00 121.90 ? 57  GLU B OE1 1 
ATOM 1883 O OE2 . GLU B 2 57  ? 253.210 94.560  286.831 1.00 123.47 ? 57  GLU B OE2 1 
ATOM 1884 N N   . HIS B 2 58  ? 250.338 100.695 288.256 1.00 106.41 ? 58  HIS B N   1 
ATOM 1885 C CA  . HIS B 2 58  ? 250.060 102.069 287.869 1.00 106.64 ? 58  HIS B CA  1 
ATOM 1886 C C   . HIS B 2 58  ? 250.695 103.056 288.841 1.00 104.88 ? 58  HIS B C   1 
ATOM 1887 O O   . HIS B 2 58  ? 251.187 104.096 288.414 1.00 105.46 ? 58  HIS B O   1 
ATOM 1888 C CB  . HIS B 2 58  ? 248.554 102.329 287.792 1.00 108.47 ? 58  HIS B CB  1 
ATOM 1889 C CG  . HIS B 2 58  ? 247.930 101.795 286.559 1.00 111.75 ? 58  HIS B CG  1 
ATOM 1890 N ND1 . HIS B 2 58  ? 246.582 101.564 286.415 1.00 116.73 ? 58  HIS B ND1 1 
ATOM 1891 C CD2 . HIS B 2 58  ? 248.483 101.481 285.392 1.00 115.99 ? 58  HIS B CD2 1 
ATOM 1892 C CE1 . HIS B 2 58  ? 246.348 101.105 285.195 1.00 117.97 ? 58  HIS B CE1 1 
ATOM 1893 N NE2 . HIS B 2 58  ? 247.489 101.048 284.557 1.00 116.80 ? 58  HIS B NE2 1 
ATOM 1894 N N   . ILE B 2 59  ? 250.632 102.750 290.139 1.00 104.11 ? 59  ILE B N   1 
ATOM 1895 C CA  . ILE B 2 59  ? 251.130 103.651 291.162 1.00 103.62 ? 59  ILE B CA  1 
ATOM 1896 C C   . ILE B 2 59  ? 252.655 103.662 291.116 1.00 101.58 ? 59  ILE B C   1 
ATOM 1897 O O   . ILE B 2 59  ? 253.249 104.725 291.271 1.00 103.57 ? 59  ILE B O   1 
ATOM 1898 C CB  . ILE B 2 59  ? 250.572 103.273 292.547 1.00 107.54 ? 59  ILE B CB  1 
ATOM 1899 C CG1 . ILE B 2 59  ? 249.065 103.517 292.596 1.00 112.45 ? 59  ILE B CG1 1 
ATOM 1900 C CG2 . ILE B 2 59  ? 251.291 104.011 293.677 1.00 110.10 ? 59  ILE B CG2 1 
ATOM 1901 C CD1 . ILE B 2 59  ? 248.403 103.163 293.918 1.00 116.50 ? 59  ILE B CD1 1 
ATOM 1902 N N   . ILE B 2 60  ? 253.286 102.506 290.884 1.00 100.56 ? 60  ILE B N   1 
ATOM 1903 C CA  . ILE B 2 60  ? 254.740 102.447 290.802 1.00 100.92 ? 60  ILE B CA  1 
ATOM 1904 C C   . ILE B 2 60  ? 255.231 103.279 289.613 1.00 99.29  ? 60  ILE B C   1 
ATOM 1905 O O   . ILE B 2 60  ? 256.213 104.003 289.740 1.00 99.94  ? 60  ILE B O   1 
ATOM 1906 C CB  . ILE B 2 60  ? 255.240 100.991 290.731 1.00 104.10 ? 60  ILE B CB  1 
ATOM 1907 C CG1 . ILE B 2 60  ? 255.020 100.263 292.062 1.00 105.59 ? 60  ILE B CG1 1 
ATOM 1908 C CG2 . ILE B 2 60  ? 256.703 100.923 290.280 1.00 105.64 ? 60  ILE B CG2 1 
ATOM 1909 C CD1 . ILE B 2 60  ? 255.143 98.752  291.982 1.00 107.63 ? 60  ILE B CD1 1 
ATOM 1910 N N   . ARG B 2 61  ? 254.566 103.176 288.460 1.00 100.27 ? 61  ARG B N   1 
ATOM 1911 C CA  . ARG B 2 61  ? 254.977 103.912 287.272 1.00 100.45 ? 61  ARG B CA  1 
ATOM 1912 C C   . ARG B 2 61  ? 254.820 105.418 287.490 1.00 98.38  ? 61  ARG B C   1 
ATOM 1913 O O   . ARG B 2 61  ? 255.698 106.166 287.088 1.00 100.49 ? 61  ARG B O   1 
ATOM 1914 C CB  . ARG B 2 61  ? 254.238 103.401 286.029 1.00 104.49 ? 61  ARG B CB  1 
ATOM 1915 C CG  . ARG B 2 61  ? 254.328 104.260 284.777 1.00 107.80 ? 61  ARG B CG  1 
ATOM 1916 C CD  . ARG B 2 61  ? 254.164 103.464 283.490 1.00 109.26 ? 61  ARG B CD  1 
ATOM 1917 N NE  . ARG B 2 61  ? 255.450 102.852 283.144 1.00 113.31 ? 61  ARG B NE  1 
ATOM 1918 C CZ  . ARG B 2 61  ? 255.760 101.565 283.184 1.00 118.65 ? 61  ARG B CZ  1 
ATOM 1919 N NH1 . ARG B 2 61  ? 257.018 101.193 283.003 1.00 120.43 ? 61  ARG B NH1 1 
ATOM 1920 N NH2 . ARG B 2 61  ? 254.843 100.646 283.444 1.00 122.85 ? 61  ARG B NH2 1 
ATOM 1921 N N   . GLU B 2 62  ? 253.725 105.872 288.111 1.00 99.66  ? 62  GLU B N   1 
ATOM 1922 C CA  . GLU B 2 62  ? 253.543 107.294 288.365 1.00 99.91  ? 62  GLU B CA  1 
ATOM 1923 C C   . GLU B 2 62  ? 254.536 107.788 289.411 1.00 96.73  ? 62  GLU B C   1 
ATOM 1924 O O   . GLU B 2 62  ? 254.932 108.941 289.356 1.00 98.25  ? 62  GLU B O   1 
ATOM 1925 C CB  . GLU B 2 62  ? 252.135 107.665 288.828 1.00 106.62 ? 62  GLU B CB  1 
ATOM 1926 C CG  . GLU B 2 62  ? 251.087 107.549 287.724 1.00 113.41 ? 62  GLU B CG  1 
ATOM 1927 C CD  . GLU B 2 62  ? 251.229 108.543 286.577 1.00 118.37 ? 62  GLU B CD  1 
ATOM 1928 O OE1 . GLU B 2 62  ? 251.097 109.758 286.858 1.00 119.88 ? 62  GLU B OE1 1 
ATOM 1929 O OE2 . GLU B 2 62  ? 251.454 108.121 285.412 1.00 119.62 ? 62  GLU B OE2 1 
ATOM 1930 N N   . ASP B 2 63  ? 254.924 106.941 290.366 1.00 98.67  ? 63  ASP B N   1 
ATOM 1931 C CA  . ASP B 2 63  ? 255.923 107.316 291.358 1.00 101.99 ? 63  ASP B CA  1 
ATOM 1932 C C   . ASP B 2 63  ? 257.299 107.481 290.715 1.00 99.31  ? 63  ASP B C   1 
ATOM 1933 O O   . ASP B 2 63  ? 258.004 108.432 291.036 1.00 100.19 ? 63  ASP B O   1 
ATOM 1934 C CB  . ASP B 2 63  ? 255.986 106.325 292.511 1.00 107.08 ? 63  ASP B CB  1 
ATOM 1935 C CG  . ASP B 2 63  ? 254.874 106.428 293.548 1.00 110.83 ? 63  ASP B CG  1 
ATOM 1936 O OD1 . ASP B 2 63  ? 254.027 107.341 293.420 1.00 115.03 ? 63  ASP B OD1 1 
ATOM 1937 O OD2 . ASP B 2 63  ? 254.859 105.592 294.480 1.00 111.67 ? 63  ASP B OD2 1 
ATOM 1938 N N   . TYR B 2 64  ? 257.693 106.539 289.848 1.00 99.41  ? 64  TYR B N   1 
ATOM 1939 C CA  . TYR B 2 64  ? 258.925 106.659 289.082 1.00 97.94  ? 64  TYR B CA  1 
ATOM 1940 C C   . TYR B 2 64  ? 258.887 107.912 288.210 1.00 93.77  ? 64  TYR B C   1 
ATOM 1941 O O   . TYR B 2 64  ? 259.889 108.607 288.113 1.00 97.64  ? 64  TYR B O   1 
ATOM 1942 C CB  . TYR B 2 64  ? 259.193 105.461 288.165 1.00 99.79  ? 64  TYR B CB  1 
ATOM 1943 C CG  . TYR B 2 64  ? 259.784 104.196 288.774 1.00 102.49 ? 64  TYR B CG  1 
ATOM 1944 C CD1 . TYR B 2 64  ? 260.311 104.158 290.063 1.00 106.28 ? 64  TYR B CD1 1 
ATOM 1945 C CD2 . TYR B 2 64  ? 259.867 103.039 288.010 1.00 105.61 ? 64  TYR B CD2 1 
ATOM 1946 C CE1 . TYR B 2 64  ? 260.863 103.000 290.587 1.00 109.16 ? 64  TYR B CE1 1 
ATOM 1947 C CE2 . TYR B 2 64  ? 260.425 101.877 288.519 1.00 111.33 ? 64  TYR B CE2 1 
ATOM 1948 C CZ  . TYR B 2 64  ? 260.924 101.859 289.812 1.00 112.05 ? 64  TYR B CZ  1 
ATOM 1949 O OH  . TYR B 2 64  ? 261.480 100.732 290.349 1.00 115.63 ? 64  TYR B OH  1 
ATOM 1950 N N   . LEU B 2 65  ? 257.745 108.201 287.582 1.00 90.89  ? 65  LEU B N   1 
ATOM 1951 C CA  . LEU B 2 65  ? 257.622 109.354 286.705 1.00 88.70  ? 65  LEU B CA  1 
ATOM 1952 C C   . LEU B 2 65  ? 257.871 110.643 287.483 1.00 88.70  ? 65  LEU B C   1 
ATOM 1953 O O   . LEU B 2 65  ? 258.524 111.548 286.982 1.00 88.98  ? 65  LEU B O   1 
ATOM 1954 C CB  . LEU B 2 65  ? 256.244 109.374 286.047 1.00 89.26  ? 65  LEU B CB  1 
ATOM 1955 C CG  . LEU B 2 65  ? 255.922 110.560 285.136 1.00 87.61  ? 65  LEU B CG  1 
ATOM 1956 C CD1 . LEU B 2 65  ? 256.877 110.635 283.965 1.00 90.01  ? 65  LEU B CD1 1 
ATOM 1957 C CD2 . LEU B 2 65  ? 254.496 110.494 284.640 1.00 88.64  ? 65  LEU B CD2 1 
ATOM 1958 N N   . VAL B 2 66  ? 257.333 110.733 288.698 1.00 89.87  ? 66  VAL B N   1 
ATOM 1959 C CA  . VAL B 2 66  ? 257.513 111.917 289.514 1.00 88.63  ? 66  VAL B CA  1 
ATOM 1960 C C   . VAL B 2 66  ? 258.991 112.058 289.851 1.00 90.71  ? 66  VAL B C   1 
ATOM 1961 O O   . VAL B 2 66  ? 259.499 113.171 289.859 1.00 97.23  ? 66  VAL B O   1 
ATOM 1962 C CB  . VAL B 2 66  ? 256.613 111.880 290.765 1.00 91.66  ? 66  VAL B CB  1 
ATOM 1963 C CG1 . VAL B 2 66  ? 257.084 112.814 291.874 1.00 94.89  ? 66  VAL B CG1 1 
ATOM 1964 C CG2 . VAL B 2 66  ? 255.159 112.177 290.404 1.00 92.86  ? 66  VAL B CG2 1 
ATOM 1965 N N   . GLU B 2 67  ? 259.691 110.950 290.103 1.00 94.78  ? 67  GLU B N   1 
ATOM 1966 C CA  . GLU B 2 67  ? 261.117 111.011 290.393 1.00 97.54  ? 67  GLU B CA  1 
ATOM 1967 C C   . GLU B 2 67  ? 261.909 111.410 289.148 1.00 94.14  ? 67  GLU B C   1 
ATOM 1968 O O   . GLU B 2 67  ? 262.960 112.028 289.270 1.00 96.03  ? 67  GLU B O   1 
ATOM 1969 C CB  . GLU B 2 67  ? 261.644 109.693 290.960 1.00 104.54 ? 67  GLU B CB  1 
ATOM 1970 C CG  . GLU B 2 67  ? 261.248 109.456 292.417 1.00 111.78 ? 67  GLU B CG  1 
ATOM 1971 C CD  . GLU B 2 67  ? 261.741 108.149 293.036 1.00 117.08 ? 67  GLU B CD  1 
ATOM 1972 O OE1 . GLU B 2 67  ? 262.311 107.300 292.310 1.00 118.09 ? 67  GLU B OE1 1 
ATOM 1973 O OE2 . GLU B 2 67  ? 261.567 107.984 294.268 1.00 119.63 ? 67  GLU B OE2 1 
ATOM 1974 N N   . ALA B 2 68  ? 261.425 111.045 287.959 1.00 93.51  ? 68  ALA B N   1 
ATOM 1975 C CA  . ALA B 2 68  ? 262.080 111.447 286.723 1.00 93.13  ? 68  ALA B CA  1 
ATOM 1976 C C   . ALA B 2 68  ? 261.861 112.938 286.478 1.00 93.41  ? 68  ALA B C   1 
ATOM 1977 O O   . ALA B 2 68  ? 262.767 113.631 286.029 1.00 96.51  ? 68  ALA B O   1 
ATOM 1978 C CB  . ALA B 2 68  ? 261.582 110.622 285.556 1.00 93.49  ? 68  ALA B CB  1 
ATOM 1979 N N   . MET B 2 69  ? 260.661 113.438 286.775 1.00 95.57  ? 69  MET B N   1 
ATOM 1980 C CA  . MET B 2 69  ? 260.364 114.849 286.596 1.00 93.26  ? 69  MET B CA  1 
ATOM 1981 C C   . MET B 2 69  ? 261.286 115.675 287.485 1.00 93.72  ? 69  MET B C   1 
ATOM 1982 O O   . MET B 2 69  ? 261.786 116.697 287.040 1.00 98.34  ? 69  MET B O   1 
ATOM 1983 C CB  . MET B 2 69  ? 258.895 115.153 286.908 1.00 93.51  ? 69  MET B CB  1 
ATOM 1984 C CG  . MET B 2 69  ? 257.947 114.634 285.848 1.00 92.77  ? 69  MET B CG  1 
ATOM 1985 S SD  . MET B 2 69  ? 256.223 115.039 286.188 1.00 94.89  ? 69  MET B SD  1 
ATOM 1986 C CE  . MET B 2 69  ? 255.575 114.638 284.557 1.00 94.41  ? 69  MET B CE  1 
ATOM 1987 N N   . GLU B 2 70  ? 261.528 115.229 288.720 1.00 96.11  ? 70  GLU B N   1 
ATOM 1988 C CA  . GLU B 2 70  ? 262.432 115.931 289.616 1.00 100.54 ? 70  GLU B CA  1 
ATOM 1989 C C   . GLU B 2 70  ? 263.845 115.997 289.034 1.00 98.44  ? 70  GLU B C   1 
ATOM 1990 O O   . GLU B 2 70  ? 264.545 116.973 289.277 1.00 103.00 ? 70  GLU B O   1 
ATOM 1991 C CB  . GLU B 2 70  ? 262.458 115.304 291.011 1.00 109.53 ? 70  GLU B CB  1 
ATOM 1992 C CG  . GLU B 2 70  ? 261.195 115.609 291.815 1.00 117.67 ? 70  GLU B CG  1 
ATOM 1993 C CD  . GLU B 2 70  ? 261.177 115.137 293.262 1.00 128.07 ? 70  GLU B CD  1 
ATOM 1994 O OE1 . GLU B 2 70  ? 262.182 114.535 293.732 1.00 133.40 ? 70  GLU B OE1 1 
ATOM 1995 O OE2 . GLU B 2 70  ? 260.140 115.408 293.926 1.00 131.01 ? 70  GLU B OE2 1 
ATOM 1996 N N   . ILE B 2 71  ? 264.269 114.989 288.266 1.00 94.86  ? 71  ILE B N   1 
ATOM 1997 C CA  . ILE B 2 71  ? 265.602 115.008 287.679 1.00 93.21  ? 71  ILE B CA  1 
ATOM 1998 C C   . ILE B 2 71  ? 265.645 115.986 286.500 1.00 89.30  ? 71  ILE B C   1 
ATOM 1999 O O   . ILE B 2 71  ? 266.604 116.734 286.364 1.00 89.21  ? 71  ILE B O   1 
ATOM 2000 C CB  . ILE B 2 71  ? 266.056 113.588 287.285 1.00 94.95  ? 71  ILE B CB  1 
ATOM 2001 C CG1 . ILE B 2 71  ? 266.317 112.734 288.537 1.00 99.64  ? 71  ILE B CG1 1 
ATOM 2002 C CG2 . ILE B 2 71  ? 267.269 113.622 286.354 1.00 92.31  ? 71  ILE B CG2 1 
ATOM 2003 C CD1 . ILE B 2 71  ? 266.469 111.243 288.274 1.00 103.25 ? 71  ILE B CD1 1 
ATOM 2004 N N   . LEU B 2 72  ? 264.617 116.001 285.652 1.00 89.46  ? 72  LEU B N   1 
ATOM 2005 C CA  . LEU B 2 72  ? 264.615 116.892 284.503 1.00 89.24  ? 72  LEU B CA  1 
ATOM 2006 C C   . LEU B 2 72  ? 264.497 118.348 284.945 1.00 90.83  ? 72  LEU B C   1 
ATOM 2007 O O   . LEU B 2 72  ? 265.032 119.238 284.300 1.00 90.85  ? 72  LEU B O   1 
ATOM 2008 C CB  . LEU B 2 72  ? 263.477 116.537 283.549 1.00 89.56  ? 72  LEU B CB  1 
ATOM 2009 C CG  . LEU B 2 72  ? 263.591 115.189 282.833 1.00 89.85  ? 72  LEU B CG  1 
ATOM 2010 C CD1 . LEU B 2 72  ? 262.345 114.947 282.006 1.00 93.75  ? 72  LEU B CD1 1 
ATOM 2011 C CD2 . LEU B 2 72  ? 264.820 115.090 281.962 1.00 90.26  ? 72  LEU B CD2 1 
ATOM 2012 N N   . GLU B 2 73  ? 263.757 118.589 286.030 1.00 95.66  ? 73  GLU B N   1 
ATOM 2013 C CA  . GLU B 2 73  ? 263.609 119.965 286.567 1.00 95.70  ? 73  GLU B CA  1 
ATOM 2014 C C   . GLU B 2 73  ? 264.986 120.425 287.066 1.00 91.25  ? 73  GLU B C   1 
ATOM 2015 O O   . GLU B 2 73  ? 265.265 121.637 286.969 1.00 91.77  ? 73  GLU B O   1 
ATOM 2016 C CB  . GLU B 2 73  ? 262.542 119.997 287.660 1.00 105.64 ? 73  GLU B CB  1 
ATOM 2017 C CG  . GLU B 2 73  ? 262.076 121.411 287.995 1.00 115.44 ? 73  GLU B CG  1 
ATOM 2018 C CD  . GLU B 2 73  ? 262.861 122.077 289.112 1.00 126.57 ? 73  GLU B CD  1 
ATOM 2019 O OE1 . GLU B 2 73  ? 263.946 121.571 289.467 1.00 128.31 ? 73  GLU B OE1 1 
ATOM 2020 O OE2 . GLU B 2 73  ? 262.385 123.106 289.630 1.00 132.43 ? 73  GLU B OE2 1 
ATOM 2021 N N   . LEU B 2 74  ? 265.800 119.502 287.591 1.00 93.79  ? 74  LEU B N   1 
ATOM 2022 C CA  . LEU B 2 74  ? 267.144 119.837 288.038 1.00 94.11  ? 74  LEU B CA  1 
ATOM 2023 C C   . LEU B 2 74  ? 268.060 120.145 286.851 1.00 90.87  ? 74  LEU B C   1 
ATOM 2024 O O   . LEU B 2 74  ? 268.860 121.064 286.939 1.00 91.32  ? 74  LEU B O   1 
ATOM 2025 C CB  . LEU B 2 74  ? 267.673 118.700 288.911 1.00 97.74  ? 74  LEU B CB  1 
ATOM 2026 C CG  . LEU B 2 74  ? 269.118 118.827 289.402 1.00 102.45 ? 74  LEU B CG  1 
ATOM 2027 C CD1 . LEU B 2 74  ? 269.293 118.299 290.825 1.00 106.44 ? 74  LEU B CD1 1 
ATOM 2028 C CD2 . LEU B 2 74  ? 270.083 118.117 288.454 1.00 103.47 ? 74  LEU B CD2 1 
ATOM 2029 N N   . TYR B 2 75  ? 267.960 119.396 285.749 1.00 92.13  ? 75  TYR B N   1 
ATOM 2030 C CA  . TYR B 2 75  ? 268.812 119.646 284.595 1.00 91.96  ? 75  TYR B CA  1 
ATOM 2031 C C   . TYR B 2 75  ? 268.386 120.908 283.849 1.00 90.01  ? 75  TYR B C   1 
ATOM 2032 O O   . TYR B 2 75  ? 269.242 121.587 283.297 1.00 93.17  ? 75  TYR B O   1 
ATOM 2033 C CB  . TYR B 2 75  ? 268.873 118.477 283.608 1.00 94.85  ? 75  TYR B CB  1 
ATOM 2034 C CG  . TYR B 2 75  ? 269.644 117.271 284.120 1.00 96.96  ? 75  TYR B CG  1 
ATOM 2035 C CD1 . TYR B 2 75  ? 270.724 117.408 284.981 1.00 97.31  ? 75  TYR B CD1 1 
ATOM 2036 C CD2 . TYR B 2 75  ? 269.279 115.985 283.742 1.00 102.26 ? 75  TYR B CD2 1 
ATOM 2037 C CE1 . TYR B 2 75  ? 271.413 116.303 285.450 1.00 101.41 ? 75  TYR B CE1 1 
ATOM 2038 C CE2 . TYR B 2 75  ? 269.962 114.872 284.208 1.00 102.22 ? 75  TYR B CE2 1 
ATOM 2039 C CZ  . TYR B 2 75  ? 271.031 115.032 285.067 1.00 100.48 ? 75  TYR B CZ  1 
ATOM 2040 O OH  . TYR B 2 75  ? 271.703 113.941 285.530 1.00 100.72 ? 75  TYR B OH  1 
ATOM 2041 N N   . CYS B 2 76  ? 267.094 121.231 283.810 1.00 88.01  ? 76  CYS B N   1 
ATOM 2042 C CA  . CYS B 2 76  ? 266.688 122.515 283.265 1.00 89.17  ? 76  CYS B CA  1 
ATOM 2043 C C   . CYS B 2 76  ? 267.279 123.649 284.097 1.00 87.54  ? 76  CYS B C   1 
ATOM 2044 O O   . CYS B 2 76  ? 267.773 124.624 283.544 1.00 87.00  ? 76  CYS B O   1 
ATOM 2045 C CB  . CYS B 2 76  ? 265.176 122.671 283.219 1.00 93.26  ? 76  CYS B CB  1 
ATOM 2046 S SG  . CYS B 2 76  ? 264.419 121.672 281.913 1.00 102.49 ? 76  CYS B SG  1 
ATOM 2047 N N   . ASP B 2 77  ? 267.180 123.572 285.414 1.00 88.83  ? 77  ASP B N   1 
ATOM 2048 C CA  . ASP B 2 77  ? 267.707 124.642 286.292 1.00 91.54  ? 77  ASP B CA  1 
ATOM 2049 C C   . ASP B 2 77  ? 269.234 124.692 286.182 1.00 89.86  ? 77  ASP B C   1 
ATOM 2050 O O   . ASP B 2 77  ? 269.771 125.758 286.444 1.00 91.68  ? 77  ASP B O   1 
ATOM 2051 C CB  . ASP B 2 77  ? 267.225 124.476 287.720 1.00 99.96  ? 77  ASP B CB  1 
ATOM 2052 C CG  . ASP B 2 77  ? 266.923 125.762 288.472 1.00 108.93 ? 77  ASP B CG  1 
ATOM 2053 O OD1 . ASP B 2 77  ? 266.421 126.714 287.840 1.00 112.08 ? 77  ASP B OD1 1 
ATOM 2054 O OD2 . ASP B 2 77  ? 267.185 125.798 289.688 1.00 116.39 ? 77  ASP B OD2 1 
ATOM 2055 N N   . LEU B 2 78  ? 269.911 123.597 285.846 1.00 90.58  ? 78  LEU B N   1 
ATOM 2056 C CA  . LEU B 2 78  ? 271.351 123.653 285.666 1.00 90.64  ? 78  LEU B CA  1 
ATOM 2057 C C   . LEU B 2 78  ? 271.684 124.398 284.372 1.00 89.40  ? 78  LEU B C   1 
ATOM 2058 O O   . LEU B 2 78  ? 272.593 125.216 284.357 1.00 91.30  ? 78  LEU B O   1 
ATOM 2059 C CB  . LEU B 2 78  ? 271.944 122.248 285.691 1.00 93.07  ? 78  LEU B CB  1 
ATOM 2060 C CG  . LEU B 2 78  ? 273.472 122.165 285.620 1.00 96.26  ? 78  LEU B CG  1 
ATOM 2061 C CD1 . LEU B 2 78  ? 273.985 120.929 286.343 1.00 100.45 ? 78  LEU B CD1 1 
ATOM 2062 C CD2 . LEU B 2 78  ? 273.959 122.158 284.180 1.00 97.98  ? 78  LEU B CD2 1 
ATOM 2063 N N   . LEU B 2 79  ? 270.963 124.135 283.281 1.00 89.75  ? 79  LEU B N   1 
ATOM 2064 C CA  . LEU B 2 79  ? 271.218 124.859 282.043 1.00 88.89  ? 79  LEU B CA  1 
ATOM 2065 C C   . LEU B 2 79  ? 270.910 126.342 282.239 1.00 89.85  ? 79  LEU B C   1 
ATOM 2066 O O   . LEU B 2 79  ? 271.563 127.175 281.634 1.00 95.01  ? 79  LEU B O   1 
ATOM 2067 C CB  . LEU B 2 79  ? 270.441 124.334 280.835 1.00 89.89  ? 79  LEU B CB  1 
ATOM 2068 C CG  . LEU B 2 79  ? 270.757 122.913 280.352 1.00 91.61  ? 79  LEU B CG  1 
ATOM 2069 C CD1 . LEU B 2 79  ? 270.127 122.702 278.982 1.00 88.59  ? 79  LEU B CD1 1 
ATOM 2070 C CD2 . LEU B 2 79  ? 272.244 122.569 280.321 1.00 93.63  ? 79  LEU B CD2 1 
ATOM 2071 N N   . LEU B 2 80  ? 269.910 126.689 283.052 1.00 91.23  ? 80  LEU B N   1 
ATOM 2072 C CA  . LEU B 2 80  ? 269.615 128.091 283.308 1.00 87.62  ? 80  LEU B CA  1 
ATOM 2073 C C   . LEU B 2 80  ? 270.740 128.709 284.133 1.00 90.88  ? 80  LEU B C   1 
ATOM 2074 O O   . LEU B 2 80  ? 271.072 129.872 283.928 1.00 94.23  ? 80  LEU B O   1 
ATOM 2075 C CB  . LEU B 2 80  ? 268.261 128.266 283.995 1.00 86.68  ? 80  LEU B CB  1 
ATOM 2076 C CG  . LEU B 2 80  ? 267.033 128.121 283.089 1.00 89.74  ? 80  LEU B CG  1 
ATOM 2077 C CD1 . LEU B 2 80  ? 265.741 128.273 283.882 1.00 95.47  ? 80  LEU B CD1 1 
ATOM 2078 C CD2 . LEU B 2 80  ? 267.023 129.102 281.928 1.00 88.66  ? 80  LEU B CD2 1 
ATOM 2079 N N   . ALA B 2 81  ? 271.324 127.936 285.057 1.00 91.56  ? 81  ALA B N   1 
ATOM 2080 C CA  . ALA B 2 81  ? 272.365 128.450 285.935 1.00 91.68  ? 81  ALA B CA  1 
ATOM 2081 C C   . ALA B 2 81  ? 273.655 128.697 285.162 1.00 90.80  ? 81  ALA B C   1 
ATOM 2082 O O   . ALA B 2 81  ? 274.413 129.599 285.502 1.00 95.21  ? 81  ALA B O   1 
ATOM 2083 C CB  . ALA B 2 81  ? 272.600 127.501 287.093 1.00 94.13  ? 81  ALA B CB  1 
ATOM 2084 N N   . ARG B 2 82  ? 273.904 127.887 284.135 1.00 90.38  ? 82  ARG B N   1 
ATOM 2085 C CA  . ARG B 2 82  ? 275.128 127.987 283.362 1.00 91.00  ? 82  ARG B CA  1 
ATOM 2086 C C   . ARG B 2 82  ? 274.778 128.361 281.930 1.00 90.17  ? 82  ARG B C   1 
ATOM 2087 O O   . ARG B 2 82  ? 275.362 127.812 280.983 1.00 90.49  ? 82  ARG B O   1 
ATOM 2088 C CB  . ARG B 2 82  ? 275.887 126.660 283.360 1.00 92.80  ? 82  ARG B CB  1 
ATOM 2089 C CG  . ARG B 2 82  ? 276.244 126.199 284.762 1.00 97.36  ? 82  ARG B CG  1 
ATOM 2090 C CD  . ARG B 2 82  ? 277.010 124.904 284.758 1.00 102.27 ? 82  ARG B CD  1 
ATOM 2091 N NE  . ARG B 2 82  ? 277.120 124.415 286.134 1.00 107.94 ? 82  ARG B NE  1 
ATOM 2092 C CZ  . ARG B 2 82  ? 277.704 123.278 286.496 1.00 115.89 ? 82  ARG B CZ  1 
ATOM 2093 N NH1 . ARG B 2 82  ? 277.650 122.895 287.764 1.00 118.80 ? 82  ARG B NH1 1 
ATOM 2094 N NH2 . ARG B 2 82  ? 278.314 122.512 285.599 1.00 117.00 ? 82  ARG B NH2 1 
ATOM 2095 N N   . PHE B 2 83  ? 273.815 129.279 281.782 1.00 91.53  ? 83  PHE B N   1 
ATOM 2096 C CA  . PHE B 2 83  ? 273.288 129.616 280.471 1.00 93.30  ? 83  PHE B CA  1 
ATOM 2097 C C   . PHE B 2 83  ? 274.308 130.427 279.685 1.00 95.30  ? 83  PHE B C   1 
ATOM 2098 O O   . PHE B 2 83  ? 274.303 130.406 278.458 1.00 96.27  ? 83  PHE B O   1 
ATOM 2099 C CB  . PHE B 2 83  ? 271.977 130.389 280.604 1.00 94.97  ? 83  PHE B CB  1 
ATOM 2100 C CG  . PHE B 2 83  ? 271.206 130.446 279.299 1.00 95.04  ? 83  PHE B CG  1 
ATOM 2101 C CD1 . PHE B 2 83  ? 270.425 129.373 278.888 1.00 99.20  ? 83  PHE B CD1 1 
ATOM 2102 C CD2 . PHE B 2 83  ? 271.262 131.565 278.489 1.00 96.75  ? 83  PHE B CD2 1 
ATOM 2103 C CE1 . PHE B 2 83  ? 269.710 129.426 277.703 1.00 99.81  ? 83  PHE B CE1 1 
ATOM 2104 C CE2 . PHE B 2 83  ? 270.547 131.613 277.305 1.00 98.79  ? 83  PHE B CE2 1 
ATOM 2105 C CZ  . PHE B 2 83  ? 269.774 130.543 276.915 1.00 99.50  ? 83  PHE B CZ  1 
ATOM 2106 N N   . GLY B 2 84  ? 275.164 131.154 280.412 1.00 99.81  ? 84  GLY B N   1 
ATOM 2107 C CA  . GLY B 2 84  ? 276.281 131.876 279.826 1.00 102.60 ? 84  GLY B CA  1 
ATOM 2108 C C   . GLY B 2 84  ? 277.146 130.988 278.935 1.00 100.45 ? 84  GLY B C   1 
ATOM 2109 O O   . GLY B 2 84  ? 277.443 131.378 277.811 1.00 104.02 ? 84  GLY B O   1 
ATOM 2110 N N   . LEU B 2 85  ? 277.514 129.796 279.422 1.00 99.29  ? 85  LEU B N   1 
ATOM 2111 C CA  . LEU B 2 85  ? 278.336 128.869 278.657 1.00 99.24  ? 85  LEU B CA  1 
ATOM 2112 C C   . LEU B 2 85  ? 277.641 128.446 277.366 1.00 101.15 ? 85  LEU B C   1 
ATOM 2113 O O   . LEU B 2 85  ? 278.311 128.254 276.358 1.00 102.12 ? 85  LEU B O   1 
ATOM 2114 C CB  . LEU B 2 85  ? 278.682 127.630 279.476 1.00 102.34 ? 85  LEU B CB  1 
ATOM 2115 C CG  . LEU B 2 85  ? 279.556 127.849 280.711 1.00 107.24 ? 85  LEU B CG  1 
ATOM 2116 C CD1 . LEU B 2 85  ? 279.707 126.557 281.503 1.00 108.90 ? 85  LEU B CD1 1 
ATOM 2117 C CD2 . LEU B 2 85  ? 280.925 128.395 280.344 1.00 110.98 ? 85  LEU B CD2 1 
ATOM 2118 N N   . ILE B 2 86  ? 276.318 128.252 277.404 1.00 104.25 ? 86  ILE B N   1 
ATOM 2119 C CA  . ILE B 2 86  ? 275.589 127.821 276.222 1.00 106.50 ? 86  ILE B CA  1 
ATOM 2120 C C   . ILE B 2 86  ? 275.770 128.883 275.137 1.00 109.72 ? 86  ILE B C   1 
ATOM 2121 O O   . ILE B 2 86  ? 276.198 128.556 274.031 1.00 113.07 ? 86  ILE B O   1 
ATOM 2122 C CB  . ILE B 2 86  ? 274.103 127.533 276.525 1.00 107.47 ? 86  ILE B CB  1 
ATOM 2123 C CG1 . ILE B 2 86  ? 273.956 126.370 277.523 1.00 108.41 ? 86  ILE B CG1 1 
ATOM 2124 C CG2 . ILE B 2 86  ? 273.310 127.292 275.233 1.00 107.11 ? 86  ILE B CG2 1 
ATOM 2125 C CD1 . ILE B 2 86  ? 272.526 126.058 277.941 1.00 110.50 ? 86  ILE B CD1 1 
ATOM 2126 N N   . GLN B 2 87  ? 275.480 130.152 275.455 1.00 110.72 ? 87  GLN B N   1 
ATOM 2127 C CA  . GLN B 2 87  ? 275.409 131.172 274.418 1.00 111.84 ? 87  GLN B CA  1 
ATOM 2128 C C   . GLN B 2 87  ? 276.814 131.702 274.113 1.00 113.42 ? 87  GLN B C   1 
ATOM 2129 O O   . GLN B 2 87  ? 276.992 132.385 273.107 1.00 116.35 ? 87  GLN B O   1 
ATOM 2130 C CB  . GLN B 2 87  ? 274.344 132.234 274.722 1.00 113.46 ? 87  GLN B CB  1 
ATOM 2131 C CG  . GLN B 2 87  ? 274.579 133.082 275.971 1.00 117.67 ? 87  GLN B CG  1 
ATOM 2132 C CD  . GLN B 2 87  ? 273.499 134.120 276.214 1.00 121.67 ? 87  GLN B CD  1 
ATOM 2133 O OE1 . GLN B 2 87  ? 273.073 134.343 277.357 1.00 123.31 ? 87  GLN B OE1 1 
ATOM 2134 N NE2 . GLN B 2 87  ? 273.066 134.800 275.155 1.00 122.23 ? 87  GLN B NE2 1 
ATOM 2135 N N   . SER B 2 88  ? 277.811 131.354 274.945 1.00 114.30 ? 88  SER B N   1 
ATOM 2136 C CA  . SER B 2 88  ? 279.194 131.768 274.736 1.00 115.22 ? 88  SER B CA  1 
ATOM 2137 C C   . SER B 2 88  ? 279.880 130.868 273.709 1.00 117.72 ? 88  SER B C   1 
ATOM 2138 O O   . SER B 2 88  ? 280.235 131.330 272.627 1.00 119.07 ? 88  SER B O   1 
ATOM 2139 C CB  . SER B 2 88  ? 279.970 131.789 276.037 1.00 114.97 ? 88  SER B CB  1 
ATOM 2140 O OG  . SER B 2 88  ? 281.364 131.945 275.811 1.00 115.49 ? 88  SER B OG  1 
ATOM 2141 N N   . MET B 2 89  ? 280.049 129.584 274.049 1.00 122.79 ? 89  MET B N   1 
ATOM 2142 C CA  . MET B 2 89  ? 280.859 128.661 273.265 1.00 127.29 ? 89  MET B CA  1 
ATOM 2143 C C   . MET B 2 89  ? 280.055 128.155 272.069 1.00 129.71 ? 89  MET B C   1 
ATOM 2144 O O   . MET B 2 89  ? 278.841 128.366 271.999 1.00 129.87 ? 89  MET B O   1 
ATOM 2145 C CB  . MET B 2 89  ? 281.295 127.464 274.121 1.00 129.90 ? 89  MET B CB  1 
ATOM 2146 C CG  . MET B 2 89  ? 282.118 127.838 275.349 1.00 134.19 ? 89  MET B CG  1 
ATOM 2147 S SD  . MET B 2 89  ? 282.178 126.529 276.592 1.00 139.68 ? 89  MET B SD  1 
ATOM 2148 C CE  . MET B 2 89  ? 283.101 125.241 275.739 1.00 140.11 ? 89  MET B CE  1 
ATOM 2149 N N   . LYS B 2 90  ? 280.748 127.513 271.117 1.00 131.47 ? 90  LYS B N   1 
ATOM 2150 C CA  . LYS B 2 90  ? 280.091 126.762 270.055 1.00 133.91 ? 90  LYS B CA  1 
ATOM 2151 C C   . LYS B 2 90  ? 280.257 125.261 270.296 1.00 132.37 ? 90  LYS B C   1 
ATOM 2152 O O   . LYS B 2 90  ? 279.509 124.461 269.732 1.00 130.72 ? 90  LYS B O   1 
ATOM 2153 C CB  . LYS B 2 90  ? 280.612 127.168 268.671 1.00 137.65 ? 90  LYS B CB  1 
ATOM 2154 C CG  . LYS B 2 90  ? 282.058 126.793 268.361 1.00 140.30 ? 90  LYS B CG  1 
ATOM 2155 C CD  . LYS B 2 90  ? 282.581 127.383 267.052 1.00 144.51 ? 90  LYS B CD  1 
ATOM 2156 C CE  . LYS B 2 90  ? 284.009 127.003 266.721 1.00 146.09 ? 90  LYS B CE  1 
ATOM 2157 N NZ  . LYS B 2 90  ? 285.008 127.442 267.708 1.00 145.88 ? 90  LYS B NZ  1 
ATOM 2158 N N   . GLU B 2 91  ? 281.249 124.893 271.120 1.00 133.47 ? 91  GLU B N   1 
ATOM 2159 C CA  . GLU B 2 91  ? 281.460 123.516 271.543 1.00 136.11 ? 91  GLU B CA  1 
ATOM 2160 C C   . GLU B 2 91  ? 280.569 123.234 272.749 1.00 134.06 ? 91  GLU B C   1 
ATOM 2161 O O   . GLU B 2 91  ? 280.155 124.157 273.447 1.00 136.85 ? 91  GLU B O   1 
ATOM 2162 C CB  . GLU B 2 91  ? 282.910 123.245 271.953 1.00 139.39 ? 91  GLU B CB  1 
ATOM 2163 C CG  . GLU B 2 91  ? 283.950 123.652 270.910 1.00 145.20 ? 91  GLU B CG  1 
ATOM 2164 C CD  . GLU B 2 91  ? 284.204 125.151 270.745 1.00 152.28 ? 91  GLU B CD  1 
ATOM 2165 O OE1 . GLU B 2 91  ? 283.642 125.973 271.523 1.00 154.05 ? 91  GLU B OE1 1 
ATOM 2166 O OE2 . GLU B 2 91  ? 284.975 125.500 269.813 1.00 153.96 ? 91  GLU B OE2 1 
ATOM 2167 N N   . LEU B 2 92  ? 280.290 121.952 272.995 1.00 130.53 ? 92  LEU B N   1 
ATOM 2168 C CA  . LEU B 2 92  ? 279.536 121.549 274.168 1.00 128.31 ? 92  LEU B CA  1 
ATOM 2169 C C   . LEU B 2 92  ? 280.495 121.415 275.349 1.00 127.73 ? 92  LEU B C   1 
ATOM 2170 O O   . LEU B 2 92  ? 281.472 120.669 275.278 1.00 126.04 ? 92  LEU B O   1 
ATOM 2171 C CB  . LEU B 2 92  ? 278.812 120.238 273.866 1.00 128.44 ? 92  LEU B CB  1 
ATOM 2172 C CG  . LEU B 2 92  ? 278.075 119.577 275.037 1.00 127.14 ? 92  LEU B CG  1 
ATOM 2173 C CD1 . LEU B 2 92  ? 276.885 120.395 275.515 1.00 123.43 ? 92  LEU B CD1 1 
ATOM 2174 C CD2 . LEU B 2 92  ? 277.661 118.159 274.646 1.00 129.92 ? 92  LEU B CD2 1 
ATOM 2175 N N   . ASP B 2 93  ? 280.196 122.140 276.433 1.00 128.22 ? 93  ASP B N   1 
ATOM 2176 C CA  . ASP B 2 93  ? 280.978 122.038 277.653 1.00 129.90 ? 93  ASP B CA  1 
ATOM 2177 C C   . ASP B 2 93  ? 280.686 120.692 278.312 1.00 127.95 ? 93  ASP B C   1 
ATOM 2178 O O   . ASP B 2 93  ? 279.536 120.243 278.324 1.00 128.47 ? 93  ASP B O   1 
ATOM 2179 C CB  . ASP B 2 93  ? 280.731 123.216 278.586 1.00 132.48 ? 93  ASP B CB  1 
ATOM 2180 C CG  . ASP B 2 93  ? 281.514 123.160 279.893 1.00 135.41 ? 93  ASP B CG  1 
ATOM 2181 O OD1 . ASP B 2 93  ? 281.015 122.535 280.856 1.00 134.80 ? 93  ASP B OD1 1 
ATOM 2182 O OD2 . ASP B 2 93  ? 282.647 123.690 279.922 1.00 139.08 ? 93  ASP B OD2 1 
ATOM 2183 N N   . SER B 2 94  ? 281.734 120.070 278.872 1.00 126.58 ? 94  SER B N   1 
ATOM 2184 C CA  . SER B 2 94  ? 281.640 118.744 279.468 1.00 127.39 ? 94  SER B CA  1 
ATOM 2185 C C   . SER B 2 94  ? 280.722 118.718 280.697 1.00 125.22 ? 94  SER B C   1 
ATOM 2186 O O   . SER B 2 94  ? 280.145 117.674 280.999 1.00 125.83 ? 94  SER B O   1 
ATOM 2187 C CB  . SER B 2 94  ? 283.016 118.220 279.812 1.00 129.17 ? 94  SER B CB  1 
ATOM 2188 O OG  . SER B 2 94  ? 283.658 119.056 280.767 1.00 131.13 ? 94  SER B OG  1 
ATOM 2189 N N   . GLY B 2 95  ? 280.587 119.851 281.401 1.00 122.78 ? 95  GLY B N   1 
ATOM 2190 C CA  . GLY B 2 95  ? 279.685 119.956 282.539 1.00 120.97 ? 95  GLY B CA  1 
ATOM 2191 C C   . GLY B 2 95  ? 278.210 119.960 282.130 1.00 118.09 ? 95  GLY B C   1 
ATOM 2192 O O   . GLY B 2 95  ? 277.351 119.637 282.948 1.00 119.70 ? 95  GLY B O   1 
ATOM 2193 N N   . LEU B 2 96  ? 277.920 120.329 280.876 1.00 114.26 ? 96  LEU B N   1 
ATOM 2194 C CA  . LEU B 2 96  ? 276.553 120.384 280.383 1.00 113.01 ? 96  LEU B CA  1 
ATOM 2195 C C   . LEU B 2 96  ? 276.176 119.105 279.635 1.00 114.06 ? 96  LEU B C   1 
ATOM 2196 O O   . LEU B 2 96  ? 275.018 118.942 279.248 1.00 116.28 ? 96  LEU B O   1 
ATOM 2197 C CB  . LEU B 2 96  ? 276.369 121.581 279.454 1.00 112.70 ? 96  LEU B CB  1 
ATOM 2198 C CG  . LEU B 2 96  ? 276.717 122.974 279.993 1.00 111.69 ? 96  LEU B CG  1 
ATOM 2199 C CD1 . LEU B 2 96  ? 276.344 123.994 278.913 1.00 111.97 ? 96  LEU B CD1 1 
ATOM 2200 C CD2 . LEU B 2 96  ? 276.050 123.327 281.314 1.00 109.94 ? 96  LEU B CD2 1 
ATOM 2201 N N   . ALA B 2 97  ? 277.140 118.212 279.397 1.00 114.62 ? 97  ALA B N   1 
ATOM 2202 C CA  . ALA B 2 97  ? 276.919 117.110 278.470 1.00 116.16 ? 97  ALA B CA  1 
ATOM 2203 C C   . ALA B 2 97  ? 275.797 116.199 278.966 1.00 115.15 ? 97  ALA B C   1 
ATOM 2204 O O   . ALA B 2 97  ? 274.908 115.848 278.190 1.00 115.58 ? 97  ALA B O   1 
ATOM 2205 C CB  . ALA B 2 97  ? 278.208 116.345 278.251 1.00 118.21 ? 97  ALA B CB  1 
ATOM 2206 N N   . GLU B 2 98  ? 275.832 115.838 280.256 1.00 114.33 ? 98  GLU B N   1 
ATOM 2207 C CA  . GLU B 2 98  ? 274.807 114.977 280.824 1.00 113.36 ? 98  GLU B CA  1 
ATOM 2208 C C   . GLU B 2 98  ? 273.452 115.660 280.676 1.00 109.34 ? 98  GLU B C   1 
ATOM 2209 O O   . GLU B 2 98  ? 272.506 115.051 280.178 1.00 112.51 ? 98  GLU B O   1 
ATOM 2210 C CB  . GLU B 2 98  ? 275.093 114.629 282.286 1.00 116.55 ? 98  GLU B CB  1 
ATOM 2211 C CG  . GLU B 2 98  ? 274.095 113.646 282.894 1.00 119.34 ? 98  GLU B CG  1 
ATOM 2212 C CD  . GLU B 2 98  ? 274.410 113.291 284.341 1.00 124.36 ? 98  GLU B CD  1 
ATOM 2213 O OE1 . GLU B 2 98  ? 274.392 114.214 285.192 1.00 127.05 ? 98  GLU B OE1 1 
ATOM 2214 O OE2 . GLU B 2 98  ? 274.699 112.092 284.622 1.00 127.15 ? 98  GLU B OE2 1 
ATOM 2215 N N   . SER B 2 99  ? 273.387 116.934 281.072 1.00 105.74 ? 99  SER B N   1 
ATOM 2216 C CA  . SER B 2 99  ? 272.137 117.673 281.110 1.00 104.71 ? 99  SER B CA  1 
ATOM 2217 C C   . SER B 2 99  ? 271.531 117.796 279.716 1.00 102.13 ? 99  SER B C   1 
ATOM 2218 O O   . SER B 2 99  ? 270.340 117.553 279.543 1.00 103.10 ? 99  SER B O   1 
ATOM 2219 C CB  . SER B 2 99  ? 272.349 119.020 281.733 1.00 104.54 ? 99  SER B CB  1 
ATOM 2220 O OG  . SER B 2 99  ? 273.079 118.886 282.948 1.00 107.39 ? 99  SER B OG  1 
ATOM 2221 N N   . VAL B 2 100 ? 272.360 118.146 278.730 1.00 102.12 ? 100 VAL B N   1 
ATOM 2222 C CA  . VAL B 2 100 ? 271.876 118.412 277.385 1.00 103.26 ? 100 VAL B CA  1 
ATOM 2223 C C   . VAL B 2 100 ? 271.450 117.097 276.735 1.00 104.37 ? 100 VAL B C   1 
ATOM 2224 O O   . VAL B 2 100 ? 270.378 117.032 276.135 1.00 106.65 ? 100 VAL B O   1 
ATOM 2225 C CB  . VAL B 2 100 ? 272.919 119.169 276.541 1.00 102.63 ? 100 VAL B CB  1 
ATOM 2226 C CG1 . VAL B 2 100 ? 272.577 119.185 275.053 1.00 102.28 ? 100 VAL B CG1 1 
ATOM 2227 C CG2 . VAL B 2 100 ? 273.119 120.593 277.055 1.00 103.17 ? 100 VAL B CG2 1 
ATOM 2228 N N   . SER B 2 101 ? 272.270 116.048 276.862 1.00 102.09 ? 101 SER B N   1 
ATOM 2229 C CA  . SER B 2 101 ? 271.934 114.775 276.242 1.00 102.33 ? 101 SER B CA  1 
ATOM 2230 C C   . SER B 2 101 ? 270.665 114.197 276.873 1.00 101.27 ? 101 SER B C   1 
ATOM 2231 O O   . SER B 2 101 ? 269.778 113.742 276.152 1.00 101.75 ? 101 SER B O   1 
ATOM 2232 C CB  . SER B 2 101 ? 273.088 113.804 276.293 1.00 102.59 ? 101 SER B CB  1 
ATOM 2233 O OG  . SER B 2 101 ? 273.511 113.577 277.629 1.00 103.50 ? 101 SER B OG  1 
ATOM 2234 N N   . THR B 2 102 ? 270.558 114.257 278.207 1.00 98.59  ? 102 THR B N   1 
ATOM 2235 C CA  . THR B 2 102 ? 269.404 113.714 278.904 1.00 93.73  ? 102 THR B CA  1 
ATOM 2236 C C   . THR B 2 102 ? 268.138 114.441 278.447 1.00 93.01  ? 102 THR B C   1 
ATOM 2237 O O   . THR B 2 102 ? 267.156 113.784 278.109 1.00 97.66  ? 102 THR B O   1 
ATOM 2238 C CB  . THR B 2 102 ? 269.612 113.801 280.416 1.00 92.43  ? 102 THR B CB  1 
ATOM 2239 O OG1 . THR B 2 102 ? 270.753 112.998 280.695 1.00 90.28  ? 102 THR B OG1 1 
ATOM 2240 C CG2 . THR B 2 102 ? 268.436 113.256 281.200 1.00 94.27  ? 102 THR B CG2 1 
ATOM 2241 N N   . LEU B 2 103 ? 268.156 115.777 278.403 1.00 92.01  ? 103 LEU B N   1 
ATOM 2242 C CA  . LEU B 2 103 ? 266.970 116.525 278.024 1.00 91.32  ? 103 LEU B CA  1 
ATOM 2243 C C   . LEU B 2 103 ? 266.555 116.173 276.599 1.00 92.39  ? 103 LEU B C   1 
ATOM 2244 O O   . LEU B 2 103 ? 265.369 116.204 276.300 1.00 95.45  ? 103 LEU B O   1 
ATOM 2245 C CB  . LEU B 2 103 ? 267.182 118.030 278.179 1.00 91.93  ? 103 LEU B CB  1 
ATOM 2246 C CG  . LEU B 2 103 ? 267.117 118.579 279.609 1.00 93.03  ? 103 LEU B CG  1 
ATOM 2247 C CD1 . LEU B 2 103 ? 267.758 119.951 279.691 1.00 96.59  ? 103 LEU B CD1 1 
ATOM 2248 C CD2 . LEU B 2 103 ? 265.692 118.653 280.132 1.00 93.15  ? 103 LEU B CD2 1 
ATOM 2249 N N   . ILE B 2 104 ? 267.513 115.860 275.720 1.00 95.02  ? 104 ILE B N   1 
ATOM 2250 C CA  . ILE B 2 104 ? 267.181 115.517 274.344 1.00 98.81  ? 104 ILE B CA  1 
ATOM 2251 C C   . ILE B 2 104 ? 266.574 114.114 274.312 1.00 98.66  ? 104 ILE B C   1 
ATOM 2252 O O   . ILE B 2 104 ? 265.639 113.873 273.552 1.00 96.85  ? 104 ILE B O   1 
ATOM 2253 C CB  . ILE B 2 104 ? 268.407 115.648 273.415 1.00 102.18 ? 104 ILE B CB  1 
ATOM 2254 C CG1 . ILE B 2 104 ? 268.794 117.117 273.197 1.00 102.22 ? 104 ILE B CG1 1 
ATOM 2255 C CG2 . ILE B 2 104 ? 268.166 114.938 272.078 1.00 103.59 ? 104 ILE B CG2 1 
ATOM 2256 C CD1 . ILE B 2 104 ? 270.177 117.332 272.606 1.00 102.28 ? 104 ILE B CD1 1 
ATOM 2257 N N   . TRP B 2 105 ? 267.110 113.205 275.140 1.00 99.18  ? 105 TRP B N   1 
ATOM 2258 C CA  . TRP B 2 105 ? 266.641 111.830 275.210 1.00 98.88  ? 105 TRP B CA  1 
ATOM 2259 C C   . TRP B 2 105 ? 265.219 111.776 275.766 1.00 96.89  ? 105 TRP B C   1 
ATOM 2260 O O   . TRP B 2 105 ? 264.390 111.026 275.265 1.00 99.28  ? 105 TRP B O   1 
ATOM 2261 C CB  . TRP B 2 105 ? 267.603 110.995 276.066 1.00 102.61 ? 105 TRP B CB  1 
ATOM 2262 C CG  . TRP B 2 105 ? 267.252 109.534 276.154 1.00 107.17 ? 105 TRP B CG  1 
ATOM 2263 C CD1 . TRP B 2 105 ? 267.697 108.530 275.347 1.00 108.41 ? 105 TRP B CD1 1 
ATOM 2264 C CD2 . TRP B 2 105 ? 266.369 108.915 277.111 1.00 109.76 ? 105 TRP B CD2 1 
ATOM 2265 N NE1 . TRP B 2 105 ? 267.161 107.332 275.734 1.00 109.34 ? 105 TRP B NE1 1 
ATOM 2266 C CE2 . TRP B 2 105 ? 266.342 107.536 276.808 1.00 110.90 ? 105 TRP B CE2 1 
ATOM 2267 C CE3 . TRP B 2 105 ? 265.603 109.389 278.178 1.00 109.97 ? 105 TRP B CE3 1 
ATOM 2268 C CZ2 . TRP B 2 105 ? 265.577 106.632 277.534 1.00 115.28 ? 105 TRP B CZ2 1 
ATOM 2269 C CZ3 . TRP B 2 105 ? 264.847 108.492 278.895 1.00 114.20 ? 105 TRP B CZ3 1 
ATOM 2270 C CH2 . TRP B 2 105 ? 264.832 107.135 278.574 1.00 116.89 ? 105 TRP B CH2 1 
ATOM 2271 N N   . ALA B 2 106 ? 264.951 112.572 276.803 1.00 94.59  ? 106 ALA B N   1 
ATOM 2272 C CA  . ALA B 2 106 ? 263.685 112.533 277.517 1.00 92.27  ? 106 ALA B CA  1 
ATOM 2273 C C   . ALA B 2 106 ? 262.552 113.155 276.706 1.00 91.29  ? 106 ALA B C   1 
ATOM 2274 O O   . ALA B 2 106 ? 261.396 112.800 276.905 1.00 96.11  ? 106 ALA B O   1 
ATOM 2275 C CB  . ALA B 2 106 ? 263.832 113.237 278.842 1.00 92.52  ? 106 ALA B CB  1 
ATOM 2276 N N   . ALA B 2 107 ? 262.864 114.098 275.820 1.00 89.94  ? 107 ALA B N   1 
ATOM 2277 C CA  . ALA B 2 107 ? 261.830 114.916 275.211 1.00 91.26  ? 107 ALA B CA  1 
ATOM 2278 C C   . ALA B 2 107 ? 260.791 114.064 274.486 1.00 95.65  ? 107 ALA B C   1 
ATOM 2279 O O   . ALA B 2 107 ? 259.601 114.267 274.705 1.00 97.49  ? 107 ALA B O   1 
ATOM 2280 C CB  . ALA B 2 107 ? 262.447 115.921 274.281 1.00 94.41  ? 107 ALA B CB  1 
ATOM 2281 N N   . PRO B 2 108 ? 261.154 113.104 273.602 1.00 100.57 ? 108 PRO B N   1 
ATOM 2282 C CA  . PRO B 2 108 ? 260.130 112.306 272.923 1.00 102.05 ? 108 PRO B CA  1 
ATOM 2283 C C   . PRO B 2 108 ? 259.310 111.393 273.840 1.00 103.64 ? 108 PRO B C   1 
ATOM 2284 O O   . PRO B 2 108 ? 258.210 110.993 273.456 1.00 103.56 ? 108 PRO B O   1 
ATOM 2285 C CB  . PRO B 2 108 ? 260.940 111.533 271.867 1.00 101.85 ? 108 PRO B CB  1 
ATOM 2286 C CG  . PRO B 2 108 ? 262.325 111.438 272.451 1.00 101.87 ? 108 PRO B CG  1 
ATOM 2287 C CD  . PRO B 2 108 ? 262.517 112.759 273.166 1.00 101.06 ? 108 PRO B CD  1 
ATOM 2288 N N   . ARG B 2 109 ? 259.817 111.096 275.049 1.00 103.11 ? 109 ARG B N   1 
ATOM 2289 C CA  . ARG B 2 109 ? 259.044 110.371 276.046 1.00 103.48 ? 109 ARG B CA  1 
ATOM 2290 C C   . ARG B 2 109 ? 258.039 111.304 276.721 1.00 104.12 ? 109 ARG B C   1 
ATOM 2291 O O   . ARG B 2 109 ? 256.866 110.948 276.840 1.00 108.48 ? 109 ARG B O   1 
ATOM 2292 C CB  . ARG B 2 109 ? 259.892 109.714 277.138 1.00 105.62 ? 109 ARG B CB  1 
ATOM 2293 C CG  . ARG B 2 109 ? 260.623 108.442 276.737 1.00 110.13 ? 109 ARG B CG  1 
ATOM 2294 C CD  . ARG B 2 109 ? 261.927 108.664 275.994 1.00 113.31 ? 109 ARG B CD  1 
ATOM 2295 N NE  . ARG B 2 109 ? 262.525 107.377 275.620 1.00 116.99 ? 109 ARG B NE  1 
ATOM 2296 C CZ  . ARG B 2 109 ? 263.523 107.201 274.751 1.00 121.60 ? 109 ARG B CZ  1 
ATOM 2297 N NH1 . ARG B 2 109 ? 263.788 105.978 274.314 1.00 123.54 ? 109 ARG B NH1 1 
ATOM 2298 N NH2 . ARG B 2 109 ? 264.205 108.230 274.256 1.00 120.97 ? 109 ARG B NH2 1 
ATOM 2299 N N   . LEU B 2 110 ? 258.484 112.499 277.135 1.00 99.30  ? 110 LEU B N   1 
ATOM 2300 C CA  . LEU B 2 110 ? 257.694 113.349 278.013 1.00 97.91  ? 110 LEU B CA  1 
ATOM 2301 C C   . LEU B 2 110 ? 256.819 114.337 277.239 1.00 97.93  ? 110 LEU B C   1 
ATOM 2302 O O   . LEU B 2 110 ? 255.970 114.982 277.848 1.00 98.68  ? 110 LEU B O   1 
ATOM 2303 C CB  . LEU B 2 110 ? 258.625 114.097 278.967 1.00 99.23  ? 110 LEU B CB  1 
ATOM 2304 C CG  . LEU B 2 110 ? 259.011 113.430 280.295 1.00 101.48 ? 110 LEU B CG  1 
ATOM 2305 C CD1 . LEU B 2 110 ? 257.813 113.330 281.239 1.00 105.86 ? 110 LEU B CD1 1 
ATOM 2306 C CD2 . LEU B 2 110 ? 259.658 112.074 280.112 1.00 101.50 ? 110 LEU B CD2 1 
ATOM 2307 N N   . GLN B 2 111 ? 256.988 114.450 275.917 1.00 102.07 ? 111 GLN B N   1 
ATOM 2308 C CA  . GLN B 2 111 ? 256.406 115.564 275.174 1.00 108.88 ? 111 GLN B CA  1 
ATOM 2309 C C   . GLN B 2 111 ? 254.876 115.503 275.147 1.00 110.66 ? 111 GLN B C   1 
ATOM 2310 O O   . GLN B 2 111 ? 254.231 116.474 274.750 1.00 110.90 ? 111 GLN B O   1 
ATOM 2311 C CB  . GLN B 2 111 ? 256.925 115.673 273.738 1.00 113.61 ? 111 GLN B CB  1 
ATOM 2312 C CG  . GLN B 2 111 ? 256.594 114.474 272.854 1.00 120.05 ? 111 GLN B CG  1 
ATOM 2313 C CD  . GLN B 2 111 ? 257.222 114.548 271.478 1.00 124.11 ? 111 GLN B CD  1 
ATOM 2314 O OE1 . GLN B 2 111 ? 258.005 115.457 271.170 1.00 121.75 ? 111 GLN B OE1 1 
ATOM 2315 N NE2 . GLN B 2 111 ? 256.896 113.569 270.643 1.00 127.54 ? 111 GLN B NE2 1 
ATOM 2316 N N   . SER B 2 112 ? 254.299 114.362 275.537 1.00 112.12 ? 112 SER B N   1 
ATOM 2317 C CA  . SER B 2 112 ? 252.858 114.246 275.687 1.00 115.01 ? 112 SER B CA  1 
ATOM 2318 C C   . SER B 2 112 ? 252.361 115.174 276.795 1.00 112.84 ? 112 SER B C   1 
ATOM 2319 O O   . SER B 2 112 ? 251.343 115.845 276.625 1.00 113.09 ? 112 SER B O   1 
ATOM 2320 C CB  . SER B 2 112 ? 252.462 112.811 275.954 1.00 120.01 ? 112 SER B CB  1 
ATOM 2321 O OG  . SER B 2 112 ? 253.183 112.269 277.059 1.00 120.94 ? 112 SER B OG  1 
ATOM 2322 N N   . GLU B 2 113 ? 253.099 115.212 277.914 1.00 110.04 ? 113 GLU B N   1 
ATOM 2323 C CA  . GLU B 2 113 ? 252.694 115.958 279.094 1.00 109.55 ? 113 GLU B CA  1 
ATOM 2324 C C   . GLU B 2 113 ? 253.309 117.353 279.116 1.00 104.45 ? 113 GLU B C   1 
ATOM 2325 O O   . GLU B 2 113 ? 252.633 118.319 279.469 1.00 104.09 ? 113 GLU B O   1 
ATOM 2326 C CB  . GLU B 2 113 ? 253.100 115.189 280.347 1.00 114.56 ? 113 GLU B CB  1 
ATOM 2327 C CG  . GLU B 2 113 ? 252.149 114.039 280.667 1.00 122.28 ? 113 GLU B CG  1 
ATOM 2328 C CD  . GLU B 2 113 ? 252.147 113.658 282.140 1.00 126.12 ? 113 GLU B CD  1 
ATOM 2329 O OE1 . GLU B 2 113 ? 253.192 113.091 282.603 1.00 126.43 ? 113 GLU B OE1 1 
ATOM 2330 O OE2 . GLU B 2 113 ? 251.110 113.954 282.816 1.00 125.29 ? 113 GLU B OE2 1 
ATOM 2331 N N   . VAL B 2 114 ? 254.594 117.441 278.766 1.00 99.11  ? 114 VAL B N   1 
ATOM 2332 C CA  . VAL B 2 114 ? 255.320 118.692 278.862 1.00 93.26  ? 114 VAL B CA  1 
ATOM 2333 C C   . VAL B 2 114 ? 255.652 119.145 277.447 1.00 89.68  ? 114 VAL B C   1 
ATOM 2334 O O   . VAL B 2 114 ? 256.702 118.807 276.907 1.00 86.92  ? 114 VAL B O   1 
ATOM 2335 C CB  . VAL B 2 114 ? 256.571 118.523 279.741 1.00 93.21  ? 114 VAL B CB  1 
ATOM 2336 C CG1 . VAL B 2 114 ? 257.222 119.862 280.053 1.00 95.65  ? 114 VAL B CG1 1 
ATOM 2337 C CG2 . VAL B 2 114 ? 256.255 117.782 281.032 1.00 96.72  ? 114 VAL B CG2 1 
ATOM 2338 N N   . ALA B 2 115 ? 254.729 119.904 276.856 1.00 91.06  ? 115 ALA B N   1 
ATOM 2339 C CA  . ALA B 2 115 ? 254.834 120.292 275.459 1.00 95.18  ? 115 ALA B CA  1 
ATOM 2340 C C   . ALA B 2 115 ? 256.073 121.150 275.209 1.00 94.46  ? 115 ALA B C   1 
ATOM 2341 O O   . ALA B 2 115 ? 256.664 121.073 274.136 1.00 94.96  ? 115 ALA B O   1 
ATOM 2342 C CB  . ALA B 2 115 ? 253.580 121.022 275.038 1.00 98.53  ? 115 ALA B CB  1 
ATOM 2343 N N   . GLU B 2 116 ? 256.467 121.961 276.195 1.00 92.67  ? 116 GLU B N   1 
ATOM 2344 C CA  . GLU B 2 116 ? 257.593 122.863 276.027 1.00 90.88  ? 116 GLU B CA  1 
ATOM 2345 C C   . GLU B 2 116 ? 258.908 122.099 275.909 1.00 85.88  ? 116 GLU B C   1 
ATOM 2346 O O   . GLU B 2 116 ? 259.869 122.619 275.360 1.00 87.59  ? 116 GLU B O   1 
ATOM 2347 C CB  . GLU B 2 116 ? 257.679 123.858 277.182 1.00 96.45  ? 116 GLU B CB  1 
ATOM 2348 C CG  . GLU B 2 116 ? 256.597 124.934 277.119 1.00 104.45 ? 116 GLU B CG  1 
ATOM 2349 C CD  . GLU B 2 116 ? 255.199 124.488 277.537 1.00 112.97 ? 116 GLU B CD  1 
ATOM 2350 O OE1 . GLU B 2 116 ? 255.042 123.341 278.055 1.00 111.20 ? 116 GLU B OE1 1 
ATOM 2351 O OE2 . GLU B 2 116 ? 254.253 125.303 277.344 1.00 118.66 ? 116 GLU B OE2 1 
ATOM 2352 N N   . LEU B 2 117 ? 258.956 120.873 276.421 1.00 85.11  ? 117 LEU B N   1 
ATOM 2353 C CA  . LEU B 2 117 ? 260.194 120.125 276.448 1.00 83.40  ? 117 LEU B CA  1 
ATOM 2354 C C   . LEU B 2 117 ? 260.565 119.687 275.036 1.00 82.66  ? 117 LEU B C   1 
ATOM 2355 O O   . LEU B 2 117 ? 261.727 119.416 274.764 1.00 84.23  ? 117 LEU B O   1 
ATOM 2356 C CB  . LEU B 2 117 ? 260.009 118.958 277.414 1.00 85.00  ? 117 LEU B CB  1 
ATOM 2357 C CG  . LEU B 2 117 ? 261.242 118.105 277.714 1.00 87.05  ? 117 LEU B CG  1 
ATOM 2358 C CD1 . LEU B 2 117 ? 262.456 118.898 278.172 1.00 86.99  ? 117 LEU B CD1 1 
ATOM 2359 C CD2 . LEU B 2 117 ? 260.852 117.089 278.768 1.00 89.12  ? 117 LEU B CD2 1 
ATOM 2360 N N   . LYS B 2 118 ? 259.576 119.632 274.141 1.00 86.49  ? 118 LYS B N   1 
ATOM 2361 C CA  . LYS B 2 118 ? 259.821 119.417 272.723 1.00 91.67  ? 118 LYS B CA  1 
ATOM 2362 C C   . LYS B 2 118 ? 260.655 120.569 272.174 1.00 89.59  ? 118 LYS B C   1 
ATOM 2363 O O   . LYS B 2 118 ? 261.623 120.336 271.459 1.00 91.61  ? 118 LYS B O   1 
ATOM 2364 C CB  . LYS B 2 118 ? 258.486 119.286 271.971 1.00 99.84  ? 118 LYS B CB  1 
ATOM 2365 C CG  . LYS B 2 118 ? 258.517 119.161 270.443 1.00 106.28 ? 118 LYS B CG  1 
ATOM 2366 C CD  . LYS B 2 118 ? 259.437 118.047 269.942 1.00 114.28 ? 118 LYS B CD  1 
ATOM 2367 C CE  . LYS B 2 118 ? 259.299 117.667 268.488 1.00 118.22 ? 118 LYS B CE  1 
ATOM 2368 N NZ  . LYS B 2 118 ? 259.826 118.672 267.550 1.00 118.83 ? 118 LYS B NZ  1 
ATOM 2369 N N   . ILE B 2 119 ? 260.276 121.800 272.537 1.00 87.28  ? 119 ILE B N   1 
ATOM 2370 C CA  . ILE B 2 119 ? 260.917 123.005 272.039 1.00 84.37  ? 119 ILE B CA  1 
ATOM 2371 C C   . ILE B 2 119 ? 262.333 123.107 272.602 1.00 86.15  ? 119 ILE B C   1 
ATOM 2372 O O   . ILE B 2 119 ? 263.247 123.503 271.889 1.00 89.89  ? 119 ILE B O   1 
ATOM 2373 C CB  . ILE B 2 119 ? 260.073 124.248 272.375 1.00 84.61  ? 119 ILE B CB  1 
ATOM 2374 C CG1 . ILE B 2 119 ? 258.722 124.191 271.664 1.00 88.33  ? 119 ILE B CG1 1 
ATOM 2375 C CG2 . ILE B 2 119 ? 260.830 125.536 272.052 1.00 86.85  ? 119 ILE B CG2 1 
ATOM 2376 C CD1 . ILE B 2 119 ? 257.694 125.191 272.162 1.00 92.68  ? 119 ILE B CD1 1 
ATOM 2377 N N   . VAL B 2 120 ? 262.519 122.755 273.875 1.00 85.87  ? 120 VAL B N   1 
ATOM 2378 C CA  . VAL B 2 120 ? 263.840 122.785 274.479 1.00 84.08  ? 120 VAL B CA  1 
ATOM 2379 C C   . VAL B 2 120 ? 264.762 121.851 273.705 1.00 85.93  ? 120 VAL B C   1 
ATOM 2380 O O   . VAL B 2 120 ? 265.870 122.247 273.364 1.00 89.67  ? 120 VAL B O   1 
ATOM 2381 C CB  . VAL B 2 120 ? 263.791 122.440 275.979 1.00 85.07  ? 120 VAL B CB  1 
ATOM 2382 C CG1 . VAL B 2 120 ? 265.152 122.059 276.567 1.00 84.34  ? 120 VAL B CG1 1 
ATOM 2383 C CG2 . VAL B 2 120 ? 263.163 123.582 276.771 1.00 84.26  ? 120 VAL B CG2 1 
ATOM 2384 N N   . ALA B 2 121 ? 264.308 120.631 273.408 1.00 90.40  ? 121 ALA B N   1 
ATOM 2385 C CA  . ALA B 2 121 ? 265.141 119.676 272.692 1.00 95.21  ? 121 ALA B CA  1 
ATOM 2386 C C   . ALA B 2 121 ? 265.435 120.148 271.269 1.00 95.26  ? 121 ALA B C   1 
ATOM 2387 O O   . ALA B 2 121 ? 266.523 119.891 270.759 1.00 94.44  ? 121 ALA B O   1 
ATOM 2388 C CB  . ALA B 2 121 ? 264.483 118.321 272.674 1.00 99.34  ? 121 ALA B CB  1 
ATOM 2389 N N   . ASP B 2 122 ? 264.471 120.817 270.625 1.00 98.16  ? 122 ASP B N   1 
ATOM 2390 C CA  . ASP B 2 122 ? 264.663 121.329 269.275 1.00 103.02 ? 122 ASP B CA  1 
ATOM 2391 C C   . ASP B 2 122 ? 265.778 122.365 269.251 1.00 101.60 ? 122 ASP B C   1 
ATOM 2392 O O   . ASP B 2 122 ? 266.598 122.369 268.330 1.00 101.61 ? 122 ASP B O   1 
ATOM 2393 C CB  . ASP B 2 122 ? 263.419 121.996 268.718 1.00 109.76 ? 122 ASP B CB  1 
ATOM 2394 C CG  . ASP B 2 122 ? 262.292 121.047 268.333 1.00 120.72 ? 122 ASP B CG  1 
ATOM 2395 O OD1 . ASP B 2 122 ? 262.347 119.855 268.753 1.00 122.80 ? 122 ASP B OD1 1 
ATOM 2396 O OD2 . ASP B 2 122 ? 261.383 121.492 267.584 1.00 127.81 ? 122 ASP B OD2 1 
ATOM 2397 N N   . GLN B 2 123 ? 265.769 123.246 270.256 1.00 98.29  ? 123 GLN B N   1 
ATOM 2398 C CA  . GLN B 2 123 ? 266.743 124.313 270.343 1.00 95.40  ? 123 GLN B CA  1 
ATOM 2399 C C   . GLN B 2 123 ? 268.119 123.738 270.656 1.00 94.09  ? 123 GLN B C   1 
ATOM 2400 O O   . GLN B 2 123 ? 269.102 124.203 270.094 1.00 98.60  ? 123 GLN B O   1 
ATOM 2401 C CB  . GLN B 2 123 ? 266.332 125.348 271.384 1.00 98.53  ? 123 GLN B CB  1 
ATOM 2402 C CG  . GLN B 2 123 ? 265.124 126.184 270.977 1.00 100.30 ? 123 GLN B CG  1 
ATOM 2403 C CD  . GLN B 2 123 ? 265.390 127.027 269.755 1.00 101.37 ? 123 GLN B CD  1 
ATOM 2404 O OE1 . GLN B 2 123 ? 266.419 127.707 269.665 1.00 102.48 ? 123 GLN B OE1 1 
ATOM 2405 N NE2 . GLN B 2 123 ? 264.474 126.981 268.797 1.00 105.20 ? 123 GLN B NE2 1 
ATOM 2406 N N   . LEU B 2 124 ? 268.203 122.733 271.527 1.00 91.92  ? 124 LEU B N   1 
ATOM 2407 C CA  . LEU B 2 124 ? 269.491 122.129 271.831 1.00 92.44  ? 124 LEU B CA  1 
ATOM 2408 C C   . LEU B 2 124 ? 270.026 121.372 270.619 1.00 95.99  ? 124 LEU B C   1 
ATOM 2409 O O   . LEU B 2 124 ? 271.234 121.296 270.427 1.00 98.70  ? 124 LEU B O   1 
ATOM 2410 C CB  . LEU B 2 124 ? 269.373 121.215 273.043 1.00 93.86  ? 124 LEU B CB  1 
ATOM 2411 C CG  . LEU B 2 124 ? 269.105 121.909 274.380 1.00 95.75  ? 124 LEU B CG  1 
ATOM 2412 C CD1 . LEU B 2 124 ? 268.730 120.878 275.431 1.00 97.08  ? 124 LEU B CD1 1 
ATOM 2413 C CD2 . LEU B 2 124 ? 270.284 122.750 274.849 1.00 98.39  ? 124 LEU B CD2 1 
ATOM 2414 N N   . CYS B 2 125 ? 269.132 120.801 269.807 1.00 103.61 ? 125 CYS B N   1 
ATOM 2415 C CA  . CYS B 2 125 ? 269.526 120.138 268.571 1.00 108.61 ? 125 CYS B CA  1 
ATOM 2416 C C   . CYS B 2 125 ? 269.821 121.145 267.458 1.00 108.31 ? 125 CYS B C   1 
ATOM 2417 O O   . CYS B 2 125 ? 270.311 120.758 266.396 1.00 110.74 ? 125 CYS B O   1 
ATOM 2418 C CB  . CYS B 2 125 ? 268.444 119.180 268.082 1.00 113.97 ? 125 CYS B CB  1 
ATOM 2419 S SG  . CYS B 2 125 ? 268.130 117.784 269.198 1.00 121.91 ? 125 CYS B SG  1 
ATOM 2420 N N   . ALA B 2 126 ? 269.508 122.427 267.681 1.00 107.61 ? 126 ALA B N   1 
ATOM 2421 C CA  . ALA B 2 126 ? 269.880 123.474 266.741 1.00 107.00 ? 126 ALA B CA  1 
ATOM 2422 C C   . ALA B 2 126 ? 271.251 124.032 267.121 1.00 107.44 ? 126 ALA B C   1 
ATOM 2423 O O   . ALA B 2 126 ? 272.088 124.262 266.242 1.00 109.76 ? 126 ALA B O   1 
ATOM 2424 C CB  . ALA B 2 126 ? 268.814 124.552 266.695 1.00 107.68 ? 126 ALA B CB  1 
ATOM 2425 N N   . LYS B 2 127 ? 271.483 124.212 268.427 1.00 107.30 ? 127 LYS B N   1 
ATOM 2426 C CA  . LYS B 2 127 ? 272.725 124.768 268.940 1.00 107.74 ? 127 LYS B CA  1 
ATOM 2427 C C   . LYS B 2 127 ? 273.877 123.811 268.659 1.00 107.42 ? 127 LYS B C   1 
ATOM 2428 O O   . LYS B 2 127 ? 274.892 124.222 268.111 1.00 110.77 ? 127 LYS B O   1 
ATOM 2429 C CB  . LYS B 2 127 ? 272.584 125.040 270.441 1.00 110.59 ? 127 LYS B CB  1 
ATOM 2430 C CG  . LYS B 2 127 ? 273.839 125.457 271.183 1.00 112.99 ? 127 LYS B CG  1 
ATOM 2431 C CD  . LYS B 2 127 ? 274.359 126.827 270.778 1.00 116.11 ? 127 LYS B CD  1 
ATOM 2432 C CE  . LYS B 2 127 ? 275.700 127.097 271.379 1.00 117.42 ? 127 LYS B CE  1 
ATOM 2433 N NZ  . LYS B 2 127 ? 276.181 128.446 271.063 1.00 118.19 ? 127 LYS B NZ  1 
ATOM 2434 N N   . TYR B 2 128 ? 273.722 122.548 269.064 1.00 109.63 ? 128 TYR B N   1 
ATOM 2435 C CA  . TYR B 2 128 ? 274.658 121.499 268.697 1.00 113.09 ? 128 TYR B CA  1 
ATOM 2436 C C   . TYR B 2 128 ? 274.131 120.882 267.407 1.00 118.52 ? 128 TYR B C   1 
ATOM 2437 O O   . TYR B 2 128 ? 273.119 121.349 266.884 1.00 118.70 ? 128 TYR B O   1 
ATOM 2438 C CB  . TYR B 2 128 ? 274.827 120.575 269.906 1.00 112.86 ? 128 TYR B CB  1 
ATOM 2439 C CG  . TYR B 2 128 ? 275.092 121.398 271.159 1.00 113.09 ? 128 TYR B CG  1 
ATOM 2440 C CD1 . TYR B 2 128 ? 276.321 122.011 271.353 1.00 113.63 ? 128 TYR B CD1 1 
ATOM 2441 C CD2 . TYR B 2 128 ? 274.102 121.611 272.114 1.00 113.99 ? 128 TYR B CD2 1 
ATOM 2442 C CE1 . TYR B 2 128 ? 276.570 122.792 272.467 1.00 115.40 ? 128 TYR B CE1 1 
ATOM 2443 C CE2 . TYR B 2 128 ? 274.338 122.392 273.233 1.00 115.03 ? 128 TYR B CE2 1 
ATOM 2444 C CZ  . TYR B 2 128 ? 275.576 122.986 273.409 1.00 116.69 ? 128 TYR B CZ  1 
ATOM 2445 O OH  . TYR B 2 128 ? 275.844 123.758 274.505 1.00 117.58 ? 128 TYR B OH  1 
ATOM 2446 N N   . SER B 2 129 ? 274.824 119.863 266.883 1.00 123.02 ? 129 SER B N   1 
ATOM 2447 C CA  . SER B 2 129 ? 274.486 119.327 265.572 1.00 127.10 ? 129 SER B CA  1 
ATOM 2448 C C   . SER B 2 129 ? 273.246 118.432 265.649 1.00 128.20 ? 129 SER B C   1 
ATOM 2449 O O   . SER B 2 129 ? 272.984 117.816 266.680 1.00 129.06 ? 129 SER B O   1 
ATOM 2450 C CB  . SER B 2 129 ? 275.664 118.587 264.968 1.00 130.17 ? 129 SER B CB  1 
ATOM 2451 O OG  . SER B 2 129 ? 276.064 117.485 265.776 1.00 132.57 ? 129 SER B OG  1 
ATOM 2452 N N   . LYS B 2 130 ? 272.509 118.349 264.530 1.00 130.87 ? 130 LYS B N   1 
ATOM 2453 C CA  . LYS B 2 130 ? 271.411 117.402 264.361 1.00 134.10 ? 130 LYS B CA  1 
ATOM 2454 C C   . LYS B 2 130 ? 271.885 115.965 264.575 1.00 134.24 ? 130 LYS B C   1 
ATOM 2455 O O   . LYS B 2 130 ? 271.106 115.121 265.014 1.00 134.87 ? 130 LYS B O   1 
ATOM 2456 C CB  . LYS B 2 130 ? 270.817 117.452 262.947 1.00 136.48 ? 130 LYS B CB  1 
ATOM 2457 C CG  . LYS B 2 130 ? 270.168 118.769 262.537 1.00 139.98 ? 130 LYS B CG  1 
ATOM 2458 C CD  . LYS B 2 130 ? 268.833 119.056 263.221 1.00 141.74 ? 130 LYS B CD  1 
ATOM 2459 C CE  . LYS B 2 130 ? 268.207 120.349 262.763 1.00 143.57 ? 130 LYS B CE  1 
ATOM 2460 N NZ  . LYS B 2 130 ? 266.917 120.613 263.413 1.00 143.93 ? 130 LYS B NZ  1 
ATOM 2461 N N   . GLU B 2 131 ? 273.150 115.699 264.224 1.00 134.29 ? 131 GLU B N   1 
ATOM 2462 C CA  . GLU B 2 131 ? 273.746 114.383 264.370 1.00 138.08 ? 131 GLU B CA  1 
ATOM 2463 C C   . GLU B 2 131 ? 273.883 114.033 265.850 1.00 135.40 ? 131 GLU B C   1 
ATOM 2464 O O   . GLU B 2 131 ? 273.519 112.928 266.257 1.00 138.00 ? 131 GLU B O   1 
ATOM 2465 C CB  . GLU B 2 131 ? 275.101 114.338 263.662 1.00 144.82 ? 131 GLU B CB  1 
ATOM 2466 C CG  . GLU B 2 131 ? 275.000 114.544 262.150 1.00 151.31 ? 131 GLU B CG  1 
ATOM 2467 C CD  . GLU B 2 131 ? 276.312 114.396 261.390 1.00 158.62 ? 131 GLU B CD  1 
ATOM 2468 O OE1 . GLU B 2 131 ? 277.381 114.181 262.023 1.00 161.62 ? 131 GLU B OE1 1 
ATOM 2469 O OE2 . GLU B 2 131 ? 276.252 114.496 260.139 1.00 161.47 ? 131 GLU B OE2 1 
ATOM 2470 N N   . TYR B 2 132 ? 274.413 114.971 266.643 1.00 128.66 ? 132 TYR B N   1 
ATOM 2471 C CA  . TYR B 2 132 ? 274.503 114.799 268.084 1.00 125.61 ? 132 TYR B CA  1 
ATOM 2472 C C   . TYR B 2 132 ? 273.100 114.602 268.658 1.00 125.58 ? 132 TYR B C   1 
ATOM 2473 O O   . TYR B 2 132 ? 272.905 113.801 269.570 1.00 125.76 ? 132 TYR B O   1 
ATOM 2474 C CB  . TYR B 2 132 ? 275.244 116.000 268.676 1.00 123.50 ? 132 TYR B CB  1 
ATOM 2475 C CG  . TYR B 2 132 ? 275.206 116.067 270.194 1.00 120.56 ? 132 TYR B CG  1 
ATOM 2476 C CD1 . TYR B 2 132 ? 276.105 115.348 270.973 1.00 120.47 ? 132 TYR B CD1 1 
ATOM 2477 C CD2 . TYR B 2 132 ? 274.261 116.849 270.843 1.00 120.12 ? 132 TYR B CD2 1 
ATOM 2478 C CE1 . TYR B 2 132 ? 276.067 115.407 272.356 1.00 120.91 ? 132 TYR B CE1 1 
ATOM 2479 C CE2 . TYR B 2 132 ? 274.216 116.922 272.225 1.00 120.44 ? 132 TYR B CE2 1 
ATOM 2480 C CZ  . TYR B 2 132 ? 275.122 116.199 272.983 1.00 121.02 ? 132 TYR B CZ  1 
ATOM 2481 O OH  . TYR B 2 132 ? 275.090 116.253 274.347 1.00 120.51 ? 132 TYR B OH  1 
ATOM 2482 N N   . GLY B 2 133 ? 272.130 115.336 268.101 1.00 125.72 ? 133 GLY B N   1 
ATOM 2483 C CA  . GLY B 2 133 ? 270.728 115.195 268.459 1.00 126.06 ? 133 GLY B CA  1 
ATOM 2484 C C   . GLY B 2 133 ? 270.178 113.787 268.218 1.00 127.67 ? 133 GLY B C   1 
ATOM 2485 O O   . GLY B 2 133 ? 269.222 113.396 268.885 1.00 131.45 ? 133 GLY B O   1 
ATOM 2486 N N   . LYS B 2 134 ? 270.755 113.034 267.268 1.00 127.48 ? 134 LYS B N   1 
ATOM 2487 C CA  . LYS B 2 134 ? 270.350 111.652 267.036 1.00 128.02 ? 134 LYS B CA  1 
ATOM 2488 C C   . LYS B 2 134 ? 271.070 110.703 267.992 1.00 126.52 ? 134 LYS B C   1 
ATOM 2489 O O   . LYS B 2 134 ? 270.447 109.785 268.519 1.00 126.47 ? 134 LYS B O   1 
ATOM 2490 C CB  . LYS B 2 134 ? 270.571 111.215 265.586 1.00 130.89 ? 134 LYS B CB  1 
ATOM 2491 C CG  . LYS B 2 134 ? 269.556 111.813 264.613 1.00 135.81 ? 134 LYS B CG  1 
ATOM 2492 C CD  . LYS B 2 134 ? 269.655 111.309 263.175 1.00 139.46 ? 134 LYS B CD  1 
ATOM 2493 C CE  . LYS B 2 134 ? 270.908 111.733 262.451 1.00 140.83 ? 134 LYS B CE  1 
ATOM 2494 N NZ  . LYS B 2 134 ? 270.966 111.204 261.084 1.00 142.02 ? 134 LYS B NZ  1 
ATOM 2495 N N   . LEU B 2 135 ? 272.370 110.928 268.218 1.00 126.25 ? 135 LEU B N   1 
ATOM 2496 C CA  . LEU B 2 135 ? 273.151 110.105 269.134 1.00 127.16 ? 135 LEU B CA  1 
ATOM 2497 C C   . LEU B 2 135 ? 272.593 110.188 270.555 1.00 125.50 ? 135 LEU B C   1 
ATOM 2498 O O   . LEU B 2 135 ? 272.790 109.267 271.346 1.00 124.64 ? 135 LEU B O   1 
ATOM 2499 C CB  . LEU B 2 135 ? 274.621 110.523 269.121 1.00 129.44 ? 135 LEU B CB  1 
ATOM 2500 C CG  . LEU B 2 135 ? 275.390 110.336 267.806 1.00 130.68 ? 135 LEU B CG  1 
ATOM 2501 C CD1 . LEU B 2 135 ? 276.745 111.044 267.890 1.00 132.96 ? 135 LEU B CD1 1 
ATOM 2502 C CD2 . LEU B 2 135 ? 275.577 108.864 267.441 1.00 131.11 ? 135 LEU B CD2 1 
ATOM 2503 N N   . CYS B 2 136 ? 271.930 111.304 270.884 1.00 124.98 ? 136 CYS B N   1 
ATOM 2504 C CA  . CYS B 2 136 ? 271.328 111.482 272.197 1.00 123.71 ? 136 CYS B CA  1 
ATOM 2505 C C   . CYS B 2 136 ? 270.075 110.616 272.319 1.00 121.92 ? 136 CYS B C   1 
ATOM 2506 O O   . CYS B 2 136 ? 269.934 109.884 273.295 1.00 121.14 ? 136 CYS B O   1 
ATOM 2507 C CB  . CYS B 2 136 ? 271.055 112.958 272.467 1.00 122.89 ? 136 CYS B CB  1 
ATOM 2508 S SG  . CYS B 2 136 ? 272.571 113.944 272.626 1.00 124.42 ? 136 CYS B SG  1 
ATOM 2509 N N   . ARG B 2 137 ? 269.194 110.673 271.312 1.00 121.71 ? 137 ARG B N   1 
ATOM 2510 C CA  . ARG B 2 137 ? 267.903 110.002 271.371 1.00 122.23 ? 137 ARG B CA  1 
ATOM 2511 C C   . ARG B 2 137 ? 268.057 108.484 271.500 1.00 125.02 ? 137 ARG B C   1 
ATOM 2512 O O   . ARG B 2 137 ? 267.181 107.836 272.074 1.00 128.09 ? 137 ARG B O   1 
ATOM 2513 C CB  . ARG B 2 137 ? 267.044 110.417 270.170 1.00 120.52 ? 137 ARG B CB  1 
ATOM 2514 C CG  . ARG B 2 137 ? 266.288 111.703 270.466 1.00 121.96 ? 137 ARG B CG  1 
ATOM 2515 C CD  . ARG B 2 137 ? 265.503 112.264 269.302 1.00 123.55 ? 137 ARG B CD  1 
ATOM 2516 N NE  . ARG B 2 137 ? 266.376 112.991 268.376 1.00 124.78 ? 137 ARG B NE  1 
ATOM 2517 C CZ  . ARG B 2 137 ? 265.970 113.731 267.352 1.00 128.61 ? 137 ARG B CZ  1 
ATOM 2518 N NH1 . ARG B 2 137 ? 266.871 114.354 266.609 1.00 129.06 ? 137 ARG B NH1 1 
ATOM 2519 N NH2 . ARG B 2 137 ? 264.678 113.854 267.066 1.00 130.47 ? 137 ARG B NH2 1 
ATOM 2520 N N   . THR B 2 138 ? 269.162 107.924 270.986 1.00 124.97 ? 138 THR B N   1 
ATOM 2521 C CA  . THR B 2 138 ? 269.430 106.491 271.050 1.00 124.76 ? 138 THR B CA  1 
ATOM 2522 C C   . THR B 2 138 ? 270.366 106.148 272.213 1.00 124.62 ? 138 THR B C   1 
ATOM 2523 O O   . THR B 2 138 ? 270.601 104.972 272.484 1.00 127.12 ? 138 THR B O   1 
ATOM 2524 C CB  . THR B 2 138 ? 270.052 106.026 269.733 1.00 126.24 ? 138 THR B CB  1 
ATOM 2525 O OG1 . THR B 2 138 ? 271.254 106.786 269.641 1.00 126.38 ? 138 THR B OG1 1 
ATOM 2526 C CG2 . THR B 2 138 ? 269.165 106.259 268.520 1.00 128.75 ? 138 THR B CG2 1 
ATOM 2527 N N   . ASN B 2 139 ? 270.909 107.177 272.879 1.00 123.70 ? 139 ASN B N   1 
ATOM 2528 C CA  . ASN B 2 139 ? 272.001 107.061 273.840 1.00 124.32 ? 139 ASN B CA  1 
ATOM 2529 C C   . ASN B 2 139 ? 273.194 106.299 273.250 1.00 127.03 ? 139 ASN B C   1 
ATOM 2530 O O   . ASN B 2 139 ? 273.914 105.607 273.980 1.00 127.43 ? 139 ASN B O   1 
ATOM 2531 C CB  . ASN B 2 139 ? 271.558 106.479 275.182 1.00 123.62 ? 139 ASN B CB  1 
ATOM 2532 C CG  . ASN B 2 139 ? 272.602 106.689 276.261 1.00 124.70 ? 139 ASN B CG  1 
ATOM 2533 O OD1 . ASN B 2 139 ? 273.330 107.689 276.238 1.00 124.79 ? 139 ASN B OD1 1 
ATOM 2534 N ND2 . ASN B 2 139 ? 272.723 105.757 277.198 1.00 125.10 ? 139 ASN B ND2 1 
ATOM 2535 N N   . GLN B 2 140 ? 273.437 106.465 271.940 1.00 129.89 ? 140 GLN B N   1 
ATOM 2536 C CA  . GLN B 2 140 ? 274.711 106.086 271.340 1.00 131.40 ? 140 GLN B CA  1 
ATOM 2537 C C   . GLN B 2 140 ? 275.818 107.006 271.863 1.00 131.71 ? 140 GLN B C   1 
ATOM 2538 O O   . GLN B 2 140 ? 276.988 106.623 271.880 1.00 133.86 ? 140 GLN B O   1 
ATOM 2539 C CB  . GLN B 2 140 ? 274.635 106.121 269.811 1.00 132.33 ? 140 GLN B CB  1 
ATOM 2540 C CG  . GLN B 2 140 ? 273.884 104.941 269.197 1.00 135.00 ? 140 GLN B CG  1 
ATOM 2541 C CD  . GLN B 2 140 ? 273.515 105.163 267.743 1.00 138.20 ? 140 GLN B CD  1 
ATOM 2542 O OE1 . GLN B 2 140 ? 272.682 106.018 267.410 1.00 138.55 ? 140 GLN B OE1 1 
ATOM 2543 N NE2 . GLN B 2 140 ? 274.130 104.392 266.855 1.00 139.21 ? 140 GLN B NE2 1 
ATOM 2544 N N   . ILE B 2 141 ? 275.425 108.207 272.313 1.00 130.77 ? 141 ILE B N   1 
ATOM 2545 C CA  . ILE B 2 141 ? 276.333 109.201 272.876 1.00 130.40 ? 141 ILE B CA  1 
ATOM 2546 C C   . ILE B 2 141 ? 276.914 108.737 274.221 1.00 128.19 ? 141 ILE B C   1 
ATOM 2547 O O   . ILE B 2 141 ? 277.912 109.301 274.672 1.00 124.85 ? 141 ILE B O   1 
ATOM 2548 C CB  . ILE B 2 141 ? 275.608 110.566 272.984 1.00 131.39 ? 141 ILE B CB  1 
ATOM 2549 C CG1 . ILE B 2 141 ? 276.580 111.756 273.164 1.00 133.35 ? 141 ILE B CG1 1 
ATOM 2550 C CG2 . ILE B 2 141 ? 274.539 110.560 274.084 1.00 131.19 ? 141 ILE B CG2 1 
ATOM 2551 C CD1 . ILE B 2 141 ? 277.523 112.002 271.994 1.00 134.57 ? 141 ILE B CD1 1 
ATOM 2552 N N   . GLY B 2 142 ? 276.296 107.729 274.860 1.00 127.66 ? 142 GLY B N   1 
ATOM 2553 C CA  . GLY B 2 142 ? 276.821 107.132 276.083 1.00 128.13 ? 142 GLY B CA  1 
ATOM 2554 C C   . GLY B 2 142 ? 276.937 108.130 277.239 1.00 126.49 ? 142 GLY B C   1 
ATOM 2555 O O   . GLY B 2 142 ? 277.852 108.018 278.057 1.00 125.58 ? 142 GLY B O   1 
ATOM 2556 N N   . THR B 2 143 ? 275.998 109.088 277.310 1.00 125.21 ? 143 THR B N   1 
ATOM 2557 C CA  . THR B 2 143 ? 276.097 110.202 278.246 1.00 124.35 ? 143 THR B CA  1 
ATOM 2558 C C   . THR B 2 143 ? 274.767 110.469 278.966 1.00 120.74 ? 143 THR B C   1 
ATOM 2559 O O   . THR B 2 143 ? 274.765 111.153 279.990 1.00 121.06 ? 143 THR B O   1 
ATOM 2560 C CB  . THR B 2 143 ? 276.598 111.432 277.478 1.00 126.41 ? 143 THR B CB  1 
ATOM 2561 O OG1 . THR B 2 143 ? 277.811 111.045 276.832 1.00 130.31 ? 143 THR B OG1 1 
ATOM 2562 C CG2 . THR B 2 143 ? 276.906 112.624 278.371 1.00 127.04 ? 143 THR B CG2 1 
ATOM 2563 N N   . VAL B 2 144 ? 273.645 109.922 278.472 1.00 114.24 ? 144 VAL B N   1 
ATOM 2564 C CA  . VAL B 2 144 ? 272.345 110.137 279.091 1.00 109.26 ? 144 VAL B CA  1 
ATOM 2565 C C   . VAL B 2 144 ? 272.374 109.532 280.492 1.00 110.80 ? 144 VAL B C   1 
ATOM 2566 O O   . VAL B 2 144 ? 273.004 108.496 280.703 1.00 113.58 ? 144 VAL B O   1 
ATOM 2567 C CB  . VAL B 2 144 ? 271.211 109.534 278.240 1.00 107.88 ? 144 VAL B CB  1 
ATOM 2568 C CG1 . VAL B 2 144 ? 269.847 109.643 278.911 1.00 108.82 ? 144 VAL B CG1 1 
ATOM 2569 C CG2 . VAL B 2 144 ? 271.153 110.148 276.848 1.00 107.65 ? 144 VAL B CG2 1 
ATOM 2570 N N   . ASN B 2 145 ? 271.695 110.192 281.438 1.00 111.00 ? 145 ASN B N   1 
ATOM 2571 C CA  . ASN B 2 145 ? 271.703 109.792 282.835 1.00 113.37 ? 145 ASN B CA  1 
ATOM 2572 C C   . ASN B 2 145 ? 270.993 108.448 282.987 1.00 117.84 ? 145 ASN B C   1 
ATOM 2573 O O   . ASN B 2 145 ? 269.818 108.330 282.628 1.00 121.49 ? 145 ASN B O   1 
ATOM 2574 C CB  . ASN B 2 145 ? 271.063 110.872 283.701 1.00 113.81 ? 145 ASN B CB  1 
ATOM 2575 C CG  . ASN B 2 145 ? 271.067 110.519 285.169 1.00 115.00 ? 145 ASN B CG  1 
ATOM 2576 O OD1 . ASN B 2 145 ? 270.017 110.161 285.720 1.00 116.39 ? 145 ASN B OD1 1 
ATOM 2577 N ND2 . ASN B 2 145 ? 272.216 110.614 285.827 1.00 117.07 ? 145 ASN B ND2 1 
ATOM 2578 N N   . ASP B 2 146 ? 271.706 107.448 283.529 1.00 120.84 ? 146 ASP B N   1 
ATOM 2579 C CA  . ASP B 2 146 ? 271.202 106.083 283.615 1.00 124.05 ? 146 ASP B CA  1 
ATOM 2580 C C   . ASP B 2 146 ? 269.974 106.007 284.519 1.00 119.90 ? 146 ASP B C   1 
ATOM 2581 O O   . ASP B 2 146 ? 268.984 105.377 284.144 1.00 120.47 ? 146 ASP B O   1 
ATOM 2582 C CB  . ASP B 2 146 ? 272.276 105.110 284.082 1.00 128.76 ? 146 ASP B CB  1 
ATOM 2583 C CG  . ASP B 2 146 ? 273.384 104.821 283.075 1.00 133.03 ? 146 ASP B CG  1 
ATOM 2584 O OD1 . ASP B 2 146 ? 273.058 104.517 281.898 1.00 133.99 ? 146 ASP B OD1 1 
ATOM 2585 O OD2 . ASP B 2 146 ? 274.568 104.881 283.481 1.00 134.96 ? 146 ASP B OD2 1 
ATOM 2586 N N   . ARG B 2 147 ? 270.043 106.653 285.688 1.00 117.09 ? 147 ARG B N   1 
ATOM 2587 C CA  . ARG B 2 147 ? 268.989 106.546 286.682 1.00 116.86 ? 147 ARG B CA  1 
ATOM 2588 C C   . ARG B 2 147 ? 267.675 107.083 286.110 1.00 111.66 ? 147 ARG B C   1 
ATOM 2589 O O   . ARG B 2 147 ? 266.615 106.572 286.457 1.00 113.79 ? 147 ARG B O   1 
ATOM 2590 C CB  . ARG B 2 147 ? 269.416 107.220 287.991 1.00 121.52 ? 147 ARG B CB  1 
ATOM 2591 C CG  . ARG B 2 147 ? 268.402 107.117 289.124 1.00 127.85 ? 147 ARG B CG  1 
ATOM 2592 C CD  . ARG B 2 147 ? 268.918 107.643 290.456 1.00 133.31 ? 147 ARG B CD  1 
ATOM 2593 N NE  . ARG B 2 147 ? 267.819 107.882 291.402 1.00 139.23 ? 147 ARG B NE  1 
ATOM 2594 C CZ  . ARG B 2 147 ? 267.368 107.049 292.354 1.00 144.28 ? 147 ARG B CZ  1 
ATOM 2595 N NH1 . ARG B 2 147 ? 266.460 107.484 293.222 1.00 145.88 ? 147 ARG B NH1 1 
ATOM 2596 N NH2 . ARG B 2 147 ? 267.827 105.805 292.462 1.00 143.97 ? 147 ARG B NH2 1 
ATOM 2597 N N   . LEU B 2 148 ? 267.738 108.091 285.235 1.00 107.82 ? 148 LEU B N   1 
ATOM 2598 C CA  . LEU B 2 148 ? 266.539 108.604 284.594 1.00 107.43 ? 148 LEU B CA  1 
ATOM 2599 C C   . LEU B 2 148 ? 266.039 107.633 283.523 1.00 111.26 ? 148 LEU B C   1 
ATOM 2600 O O   . LEU B 2 148 ? 264.826 107.498 283.354 1.00 113.99 ? 148 LEU B O   1 
ATOM 2601 C CB  . LEU B 2 148 ? 266.770 109.994 284.013 1.00 105.25 ? 148 LEU B CB  1 
ATOM 2602 C CG  . LEU B 2 148 ? 265.600 110.560 283.201 1.00 104.49 ? 148 LEU B CG  1 
ATOM 2603 C CD1 . LEU B 2 148 ? 265.369 112.019 283.509 1.00 104.57 ? 148 LEU B CD1 1 
ATOM 2604 C CD2 . LEU B 2 148 ? 265.817 110.373 281.711 1.00 104.84 ? 148 LEU B CD2 1 
ATOM 2605 N N   . MET B 2 149 ? 266.945 106.990 282.776 1.00 113.03 ? 149 MET B N   1 
ATOM 2606 C CA  . MET B 2 149 ? 266.528 106.041 281.749 1.00 114.93 ? 149 MET B CA  1 
ATOM 2607 C C   . MET B 2 149 ? 265.792 104.855 282.376 1.00 115.13 ? 149 MET B C   1 
ATOM 2608 O O   . MET B 2 149 ? 264.840 104.347 281.788 1.00 115.87 ? 149 MET B O   1 
ATOM 2609 C CB  . MET B 2 149 ? 267.722 105.516 280.947 1.00 116.57 ? 149 MET B CB  1 
ATOM 2610 C CG  . MET B 2 149 ? 268.296 106.527 279.981 1.00 117.52 ? 149 MET B CG  1 
ATOM 2611 S SD  . MET B 2 149 ? 269.685 105.874 279.034 1.00 119.08 ? 149 MET B SD  1 
ATOM 2612 C CE  . MET B 2 149 ? 268.849 104.817 277.844 1.00 122.04 ? 149 MET B CE  1 
ATOM 2613 N N   . HIS B 2 150 ? 266.246 104.418 283.557 1.00 113.88 ? 150 HIS B N   1 
ATOM 2614 C CA  . HIS B 2 150 ? 265.590 103.358 284.304 1.00 114.08 ? 150 HIS B CA  1 
ATOM 2615 C C   . HIS B 2 150 ? 264.159 103.765 284.658 1.00 108.76 ? 150 HIS B C   1 
ATOM 2616 O O   . HIS B 2 150 ? 263.232 102.979 284.489 1.00 109.97 ? 150 HIS B O   1 
ATOM 2617 C CB  . HIS B 2 150 ? 266.427 102.995 285.537 1.00 119.28 ? 150 HIS B CB  1 
ATOM 2618 C CG  . HIS B 2 150 ? 265.773 101.981 286.414 1.00 128.38 ? 150 HIS B CG  1 
ATOM 2619 N ND1 . HIS B 2 150 ? 264.912 102.318 287.441 1.00 131.52 ? 150 HIS B ND1 1 
ATOM 2620 C CD2 . HIS B 2 150 ? 265.831 100.634 286.399 1.00 131.32 ? 150 HIS B CD2 1 
ATOM 2621 C CE1 . HIS B 2 150 ? 264.475 101.209 288.029 1.00 132.26 ? 150 HIS B CE1 1 
ATOM 2622 N NE2 . HIS B 2 150 ? 265.022 100.174 287.412 1.00 132.39 ? 150 HIS B NE2 1 
ATOM 2623 N N   . LYS B 2 151 ? 263.983 104.996 285.141 1.00 105.58 ? 151 LYS B N   1 
ATOM 2624 C CA  . LYS B 2 151 ? 262.699 105.463 285.642 1.00 104.52 ? 151 LYS B CA  1 
ATOM 2625 C C   . LYS B 2 151 ? 261.695 105.721 284.523 1.00 102.83 ? 151 LYS B C   1 
ATOM 2626 O O   . LYS B 2 151 ? 260.491 105.757 284.789 1.00 107.84 ? 151 LYS B O   1 
ATOM 2627 C CB  . LYS B 2 151 ? 262.872 106.731 286.480 1.00 105.34 ? 151 LYS B CB  1 
ATOM 2628 C CG  . LYS B 2 151 ? 263.562 106.434 287.787 1.00 109.49 ? 151 LYS B CG  1 
ATOM 2629 C CD  . LYS B 2 151 ? 263.835 107.618 288.702 1.00 113.24 ? 151 LYS B CD  1 
ATOM 2630 C CE  . LYS B 2 151 ? 264.650 107.197 289.899 1.00 118.37 ? 151 LYS B CE  1 
ATOM 2631 N NZ  . LYS B 2 151 ? 264.036 106.138 290.714 1.00 120.89 ? 151 LYS B NZ  1 
ATOM 2632 N N   . LEU B 2 152 ? 262.164 105.916 283.290 1.00 100.65 ? 152 LEU B N   1 
ATOM 2633 C CA  . LEU B 2 152 ? 261.249 106.092 282.176 1.00 102.12 ? 152 LEU B CA  1 
ATOM 2634 C C   . LEU B 2 152 ? 261.263 104.872 281.253 1.00 105.65 ? 152 LEU B C   1 
ATOM 2635 O O   . LEU B 2 152 ? 260.862 104.972 280.094 1.00 107.03 ? 152 LEU B O   1 
ATOM 2636 C CB  . LEU B 2 152 ? 261.603 107.376 281.433 1.00 101.97 ? 152 LEU B CB  1 
ATOM 2637 C CG  . LEU B 2 152 ? 261.378 108.681 282.200 1.00 103.95 ? 152 LEU B CG  1 
ATOM 2638 C CD1 . LEU B 2 152 ? 262.000 109.837 281.428 1.00 105.40 ? 152 LEU B CD1 1 
ATOM 2639 C CD2 . LEU B 2 152 ? 259.914 108.970 282.485 1.00 103.41 ? 152 LEU B CD2 1 
ATOM 2640 N N   . SER B 2 153 ? 261.673 103.709 281.779 1.00 109.43 ? 153 SER B N   1 
ATOM 2641 C CA  . SER B 2 153 ? 261.595 102.457 281.038 1.00 113.21 ? 153 SER B CA  1 
ATOM 2642 C C   . SER B 2 153 ? 260.143 102.000 280.928 1.00 115.01 ? 153 SER B C   1 
ATOM 2643 O O   . SER B 2 153 ? 259.330 102.303 281.800 1.00 114.83 ? 153 SER B O   1 
ATOM 2644 C CB  . SER B 2 153 ? 262.439 101.374 281.666 1.00 116.26 ? 153 SER B CB  1 
ATOM 2645 O OG  . SER B 2 153 ? 263.824 101.614 281.462 1.00 121.52 ? 153 SER B OG  1 
ATOM 2646 N N   . VAL B 2 154 ? 259.852 101.234 279.866 1.00 115.80 ? 154 VAL B N   1 
ATOM 2647 C CA  . VAL B 2 154 ? 258.495 100.813 279.548 1.00 115.81 ? 154 VAL B CA  1 
ATOM 2648 C C   . VAL B 2 154 ? 258.197 99.448  280.173 1.00 119.81 ? 154 VAL B C   1 
ATOM 2649 O O   . VAL B 2 154 ? 257.041 99.018  280.178 1.00 122.74 ? 154 VAL B O   1 
ATOM 2650 C CB  . VAL B 2 154 ? 258.223 100.792 278.029 1.00 115.31 ? 154 VAL B CB  1 
ATOM 2651 C CG1 . VAL B 2 154 ? 258.207 102.197 277.437 1.00 116.06 ? 154 VAL B CG1 1 
ATOM 2652 C CG2 . VAL B 2 154 ? 259.194 99.893  277.269 1.00 116.77 ? 154 VAL B CG2 1 
ATOM 2653 N N   . GLU B 2 155 ? 259.229 98.781  280.709 1.00 120.95 ? 155 GLU B N   1 
ATOM 2654 C CA  . GLU B 2 155 ? 259.099 97.457  281.297 1.00 125.36 ? 155 GLU B CA  1 
ATOM 2655 C C   . GLU B 2 155 ? 258.215 97.466  282.542 1.00 126.88 ? 155 GLU B C   1 
ATOM 2656 O O   . GLU B 2 155 ? 258.131 98.474  283.244 1.00 126.62 ? 155 GLU B O   1 
ATOM 2657 C CB  . GLU B 2 155 ? 260.465 96.909  281.705 1.00 130.13 ? 155 GLU B CB  1 
ATOM 2658 C CG  . GLU B 2 155 ? 261.221 96.263  280.547 1.00 136.00 ? 155 GLU B CG  1 
ATOM 2659 C CD  . GLU B 2 155 ? 261.610 97.197  279.408 1.00 141.03 ? 155 GLU B CD  1 
ATOM 2660 O OE1 . GLU B 2 155 ? 261.628 98.441  279.606 1.00 143.06 ? 155 GLU B OE1 1 
ATOM 2661 O OE2 . GLU B 2 155 ? 261.872 96.665  278.300 1.00 142.57 ? 155 GLU B OE2 1 
ATOM 2662 N N   . ALA B 2 156 ? 257.605 96.302  282.821 1.00 127.89 ? 156 ALA B N   1 
ATOM 2663 C CA  . ALA B 2 156 ? 256.784 96.111  284.005 1.00 127.90 ? 156 ALA B CA  1 
ATOM 2664 C C   . ALA B 2 156 ? 257.673 96.082  285.247 1.00 126.47 ? 156 ALA B C   1 
ATOM 2665 O O   . ALA B 2 156 ? 258.803 95.596  285.190 1.00 124.92 ? 156 ALA B O   1 
ATOM 2666 C CB  . ALA B 2 156 ? 255.964 94.841  283.874 1.00 130.10 ? 156 ALA B CB  1 
ATOM 2667 N N   . PRO B 2 157 ? 257.210 96.614  286.403 1.00 127.11 ? 157 PRO B N   1 
ATOM 2668 C CA  . PRO B 2 157 ? 257.981 96.541  287.643 1.00 128.06 ? 157 PRO B CA  1 
ATOM 2669 C C   . PRO B 2 157 ? 258.370 95.112  288.008 1.00 131.40 ? 157 PRO B C   1 
ATOM 2670 O O   . PRO B 2 157 ? 257.690 94.169  287.605 1.00 132.61 ? 157 PRO B O   1 
ATOM 2671 C CB  . PRO B 2 157 ? 257.042 97.146  288.698 1.00 127.31 ? 157 PRO B CB  1 
ATOM 2672 C CG  . PRO B 2 157 ? 256.121 98.046  287.912 1.00 128.28 ? 157 PRO B CG  1 
ATOM 2673 C CD  . PRO B 2 157 ? 255.950 97.357  286.571 1.00 127.66 ? 157 PRO B CD  1 
ATOM 2674 N N   . PRO B 2 158 ? 259.456 94.903  288.789 1.00 135.51 ? 158 PRO B N   1 
ATOM 2675 C CA  . PRO B 2 158 ? 259.732 93.596  289.388 1.00 137.58 ? 158 PRO B CA  1 
ATOM 2676 C C   . PRO B 2 158 ? 258.587 93.198  290.317 1.00 139.24 ? 158 PRO B C   1 
ATOM 2677 O O   . PRO B 2 158 ? 258.131 94.012  291.119 1.00 138.85 ? 158 PRO B O   1 
ATOM 2678 C CB  . PRO B 2 158 ? 261.051 93.778  290.160 1.00 138.56 ? 158 PRO B CB  1 
ATOM 2679 C CG  . PRO B 2 158 ? 261.638 95.072  289.636 1.00 138.38 ? 158 PRO B CG  1 
ATOM 2680 C CD  . PRO B 2 158 ? 260.471 95.907  289.144 1.00 137.70 ? 158 PRO B CD  1 
ATOM 2681 N N   . LYS B 2 159 ? 258.145 91.938  290.220 1.00 140.30 ? 159 LYS B N   1 
ATOM 2682 C CA  . LYS B 2 159 ? 256.967 91.484  290.948 1.00 141.64 ? 159 LYS B CA  1 
ATOM 2683 C C   . LYS B 2 159 ? 257.226 91.491  292.457 1.00 139.82 ? 159 LYS B C   1 
ATOM 2684 O O   . LYS B 2 159 ? 256.270 91.553  293.234 1.00 140.01 ? 159 LYS B O   1 
ATOM 2685 C CB  . LYS B 2 159 ? 256.434 90.146  290.411 1.00 144.76 ? 159 LYS B CB  1 
ATOM 2686 C CG  . LYS B 2 159 ? 257.440 89.041  290.109 1.00 148.67 ? 159 LYS B CG  1 
ATOM 2687 C CD  . LYS B 2 159 ? 256.855 87.906  289.269 1.00 152.37 ? 159 LYS B CD  1 
ATOM 2688 C CE  . LYS B 2 159 ? 257.877 86.907  288.782 1.00 155.09 ? 159 LYS B CE  1 
ATOM 2689 N NZ  . LYS B 2 159 ? 258.403 86.017  289.824 1.00 155.94 ? 159 LYS B NZ  1 
ATOM 2690 N N   . ILE B 2 160 ? 258.503 91.452  292.870 1.00 138.45 ? 160 ILE B N   1 
ATOM 2691 C CA  . ILE B 2 160 ? 258.864 91.581  294.279 1.00 137.83 ? 160 ILE B CA  1 
ATOM 2692 C C   . ILE B 2 160 ? 258.585 93.004  294.773 1.00 134.75 ? 160 ILE B C   1 
ATOM 2693 O O   . ILE B 2 160 ? 258.222 93.177  295.936 1.00 134.05 ? 160 ILE B O   1 
ATOM 2694 C CB  . ILE B 2 160 ? 260.323 91.130  294.540 1.00 139.29 ? 160 ILE B CB  1 
ATOM 2695 C CG1 . ILE B 2 160 ? 260.701 91.175  296.043 1.00 140.65 ? 160 ILE B CG1 1 
ATOM 2696 C CG2 . ILE B 2 160 ? 261.332 91.914  293.695 1.00 139.48 ? 160 ILE B CG2 1 
ATOM 2697 C CD1 . ILE B 2 160 ? 259.873 90.274  296.949 1.00 141.37 ? 160 ILE B CD1 1 
ATOM 2698 N N   . LEU B 2 161 ? 258.728 94.012  293.901 1.00 132.87 ? 161 LEU B N   1 
ATOM 2699 C CA  . LEU B 2 161 ? 258.402 95.385  294.264 1.00 131.35 ? 161 LEU B CA  1 
ATOM 2700 C C   . LEU B 2 161 ? 256.887 95.534  294.430 1.00 130.57 ? 161 LEU B C   1 
ATOM 2701 O O   . LEU B 2 161 ? 256.435 96.221  295.344 1.00 132.14 ? 161 LEU B O   1 
ATOM 2702 C CB  . LEU B 2 161 ? 258.960 96.373  293.236 1.00 129.72 ? 161 LEU B CB  1 
ATOM 2703 C CG  . LEU B 2 161 ? 258.710 97.864  293.503 1.00 128.84 ? 161 LEU B CG  1 
ATOM 2704 C CD1 . LEU B 2 161 ? 259.338 98.367  294.800 1.00 130.06 ? 161 LEU B CD1 1 
ATOM 2705 C CD2 . LEU B 2 161 ? 259.192 98.692  292.318 1.00 127.86 ? 161 LEU B CD2 1 
ATOM 2706 N N   . VAL B 2 162 ? 256.114 94.890  293.547 1.00 128.62 ? 162 VAL B N   1 
ATOM 2707 C CA  . VAL B 2 162 ? 254.662 94.967  293.585 1.00 128.56 ? 162 VAL B CA  1 
ATOM 2708 C C   . VAL B 2 162 ? 254.177 94.408  294.921 1.00 129.60 ? 162 VAL B C   1 
ATOM 2709 O O   . VAL B 2 162 ? 253.341 95.025  295.575 1.00 130.43 ? 162 VAL B O   1 
ATOM 2710 C CB  . VAL B 2 162 ? 254.013 94.240  292.387 1.00 129.00 ? 162 VAL B CB  1 
ATOM 2711 C CG1 . VAL B 2 162 ? 252.489 94.221  292.464 1.00 128.74 ? 162 VAL B CG1 1 
ATOM 2712 C CG2 . VAL B 2 162 ? 254.458 94.827  291.049 1.00 129.76 ? 162 VAL B CG2 1 
ATOM 2713 N N   . GLU B 2 163 ? 254.712 93.248  295.323 1.00 131.45 ? 163 GLU B N   1 
ATOM 2714 C CA  . GLU B 2 163 ? 254.333 92.624  296.582 1.00 133.75 ? 163 GLU B CA  1 
ATOM 2715 C C   . GLU B 2 163 ? 254.677 93.538  297.757 1.00 132.58 ? 163 GLU B C   1 
ATOM 2716 O O   . GLU B 2 163 ? 253.863 93.706  298.662 1.00 133.78 ? 163 GLU B O   1 
ATOM 2717 C CB  . GLU B 2 163 ? 254.984 91.247  296.728 1.00 136.76 ? 163 GLU B CB  1 
ATOM 2718 C CG  . GLU B 2 163 ? 254.349 90.169  295.848 1.00 139.90 ? 163 GLU B CG  1 
ATOM 2719 C CD  . GLU B 2 163 ? 252.855 89.933  296.034 1.00 141.14 ? 163 GLU B CD  1 
ATOM 2720 O OE1 . GLU B 2 163 ? 252.404 89.807  297.196 1.00 141.39 ? 163 GLU B OE1 1 
ATOM 2721 O OE2 . GLU B 2 163 ? 252.141 89.860  295.005 1.00 140.26 ? 163 GLU B OE2 1 
ATOM 2722 N N   . ARG B 2 164 ? 255.870 94.138  297.728 1.00 132.13 ? 164 ARG B N   1 
ATOM 2723 C CA  . ARG B 2 164 ? 256.329 94.995  298.811 1.00 131.11 ? 164 ARG B CA  1 
ATOM 2724 C C   . ARG B 2 164 ? 255.466 96.250  298.932 1.00 127.68 ? 164 ARG B C   1 
ATOM 2725 O O   . ARG B 2 164 ? 255.216 96.702  300.047 1.00 126.34 ? 164 ARG B O   1 
ATOM 2726 C CB  . ARG B 2 164 ? 257.808 95.333  298.610 1.00 133.34 ? 164 ARG B CB  1 
ATOM 2727 C CG  . ARG B 2 164 ? 258.720 94.192  299.035 1.00 135.93 ? 164 ARG B CG  1 
ATOM 2728 C CD  . ARG B 2 164 ? 260.172 94.444  298.691 1.00 139.30 ? 164 ARG B CD  1 
ATOM 2729 N NE  . ARG B 2 164 ? 261.032 93.367  299.194 1.00 142.52 ? 164 ARG B NE  1 
ATOM 2730 C CZ  . ARG B 2 164 ? 262.327 93.206  298.927 1.00 146.34 ? 164 ARG B CZ  1 
ATOM 2731 N NH1 . ARG B 2 164 ? 262.977 92.186  299.464 1.00 147.46 ? 164 ARG B NH1 1 
ATOM 2732 N NH2 . ARG B 2 164 ? 262.977 94.049  298.134 1.00 147.77 ? 164 ARG B NH2 1 
ATOM 2733 N N   . TYR B 2 165 ? 255.033 96.809  297.794 1.00 126.08 ? 165 TYR B N   1 
ATOM 2734 C CA  . TYR B 2 165 ? 254.103 97.930  297.788 1.00 126.03 ? 165 TYR B CA  1 
ATOM 2735 C C   . TYR B 2 165 ? 252.800 97.551  298.492 1.00 127.34 ? 165 TYR B C   1 
ATOM 2736 O O   . TYR B 2 165 ? 252.319 98.306  299.336 1.00 127.59 ? 165 TYR B O   1 
ATOM 2737 C CB  . TYR B 2 165 ? 253.840 98.410  296.357 1.00 124.60 ? 165 TYR B CB  1 
ATOM 2738 C CG  . TYR B 2 165 ? 254.498 99.731  295.988 1.00 123.98 ? 165 TYR B CG  1 
ATOM 2739 C CD1 . TYR B 2 165 ? 255.881 99.851  295.891 1.00 123.84 ? 165 TYR B CD1 1 
ATOM 2740 C CD2 . TYR B 2 165 ? 253.726 100.851 295.701 1.00 123.39 ? 165 TYR B CD2 1 
ATOM 2741 C CE1 . TYR B 2 165 ? 256.476 101.053 295.545 1.00 122.40 ? 165 TYR B CE1 1 
ATOM 2742 C CE2 . TYR B 2 165 ? 254.309 102.056 295.347 1.00 123.19 ? 165 TYR B CE2 1 
ATOM 2743 C CZ  . TYR B 2 165 ? 255.686 102.156 295.273 1.00 122.32 ? 165 TYR B CZ  1 
ATOM 2744 O OH  . TYR B 2 165 ? 256.255 103.343 294.923 1.00 122.99 ? 165 TYR B OH  1 
ATOM 2745 N N   . LEU B 2 166 ? 252.236 96.387  298.138 1.00 126.72 ? 166 LEU B N   1 
ATOM 2746 C CA  . LEU B 2 166 ? 250.974 95.940  298.705 1.00 125.33 ? 166 LEU B CA  1 
ATOM 2747 C C   . LEU B 2 166 ? 251.117 95.740  300.211 1.00 125.86 ? 166 LEU B C   1 
ATOM 2748 O O   . LEU B 2 166 ? 250.240 96.163  300.960 1.00 126.96 ? 166 LEU B O   1 
ATOM 2749 C CB  . LEU B 2 166 ? 250.502 94.671  297.996 1.00 125.60 ? 166 LEU B CB  1 
ATOM 2750 C CG  . LEU B 2 166 ? 249.917 94.865  296.592 1.00 124.61 ? 166 LEU B CG  1 
ATOM 2751 C CD1 . LEU B 2 166 ? 249.775 93.540  295.865 1.00 125.57 ? 166 LEU B CD1 1 
ATOM 2752 C CD2 . LEU B 2 166 ? 248.573 95.576  296.647 1.00 124.20 ? 166 LEU B CD2 1 
ATOM 2753 N N   . ILE B 2 167 ? 252.226 95.127  300.643 1.00 128.02 ? 167 ILE B N   1 
ATOM 2754 C CA  . ILE B 2 167 ? 252.481 94.868  302.055 1.00 130.88 ? 167 ILE B CA  1 
ATOM 2755 C C   . ILE B 2 167 ? 252.434 96.180  302.841 1.00 131.76 ? 167 ILE B C   1 
ATOM 2756 O O   . ILE B 2 167 ? 251.805 96.240  303.896 1.00 130.74 ? 167 ILE B O   1 
ATOM 2757 C CB  . ILE B 2 167 ? 253.820 94.121  302.244 1.00 133.16 ? 167 ILE B CB  1 
ATOM 2758 C CG1 . ILE B 2 167 ? 253.733 92.669  301.736 1.00 134.54 ? 167 ILE B CG1 1 
ATOM 2759 C CG2 . ILE B 2 167 ? 254.289 94.180  303.702 1.00 134.53 ? 167 ILE B CG2 1 
ATOM 2760 C CD1 . ILE B 2 167 ? 255.073 92.005  301.463 1.00 135.68 ? 167 ILE B CD1 1 
ATOM 2761 N N   . GLU B 2 168 ? 253.101 97.221  302.325 1.00 132.50 ? 168 GLU B N   1 
ATOM 2762 C CA  . GLU B 2 168 ? 253.234 98.481  303.039 1.00 133.55 ? 168 GLU B CA  1 
ATOM 2763 C C   . GLU B 2 168 ? 251.918 99.257  303.023 1.00 130.63 ? 168 GLU B C   1 
ATOM 2764 O O   . GLU B 2 168 ? 251.596 99.916  304.010 1.00 131.34 ? 168 GLU B O   1 
ATOM 2765 C CB  . GLU B 2 168 ? 254.394 99.304  302.474 1.00 137.53 ? 168 GLU B CB  1 
ATOM 2766 C CG  . GLU B 2 168 ? 255.772 98.742  302.823 1.00 141.40 ? 168 GLU B CG  1 
ATOM 2767 C CD  . GLU B 2 168 ? 256.085 98.667  304.312 1.00 144.09 ? 168 GLU B CD  1 
ATOM 2768 O OE1 . GLU B 2 168 ? 255.847 99.662  305.039 1.00 145.24 ? 168 GLU B OE1 1 
ATOM 2769 O OE2 . GLU B 2 168 ? 256.587 97.605  304.746 1.00 144.58 ? 168 GLU B OE2 1 
ATOM 2770 N N   . ILE B 2 169 ? 251.173 99.190  301.913 1.00 128.23 ? 169 ILE B N   1 
ATOM 2771 C CA  . ILE B 2 169 ? 249.875 99.847  301.832 1.00 127.14 ? 169 ILE B CA  1 
ATOM 2772 C C   . ILE B 2 169 ? 248.915 99.146  302.791 1.00 128.05 ? 169 ILE B C   1 
ATOM 2773 O O   . ILE B 2 169 ? 248.159 99.810  303.496 1.00 128.82 ? 169 ILE B O   1 
ATOM 2774 C CB  . ILE B 2 169 ? 249.355 99.886  300.379 1.00 126.54 ? 169 ILE B CB  1 
ATOM 2775 C CG1 . ILE B 2 169 ? 250.211 100.822 299.509 1.00 125.29 ? 169 ILE B CG1 1 
ATOM 2776 C CG2 . ILE B 2 169 ? 247.872 100.266 300.325 1.00 127.22 ? 169 ILE B CG2 1 
ATOM 2777 C CD1 . ILE B 2 169 ? 250.024 100.661 298.010 1.00 124.26 ? 169 ILE B CD1 1 
ATOM 2778 N N   . ALA B 2 170 ? 248.965 97.808  302.821 1.00 130.40 ? 170 ALA B N   1 
ATOM 2779 C CA  . ALA B 2 170 ? 248.136 97.016  303.717 1.00 132.92 ? 170 ALA B CA  1 
ATOM 2780 C C   . ALA B 2 170 ? 248.368 97.422  305.175 1.00 134.82 ? 170 ALA B C   1 
ATOM 2781 O O   . ALA B 2 170 ? 247.404 97.582  305.925 1.00 135.93 ? 170 ALA B O   1 
ATOM 2782 C CB  . ALA B 2 170 ? 248.404 95.541  303.490 1.00 134.05 ? 170 ALA B CB  1 
ATOM 2783 N N   . LYS B 2 171 ? 249.638 97.595  305.568 1.00 135.72 ? 171 LYS B N   1 
ATOM 2784 C CA  . LYS B 2 171 ? 249.982 97.998  306.925 1.00 137.74 ? 171 LYS B CA  1 
ATOM 2785 C C   . LYS B 2 171 ? 249.361 99.353  307.260 1.00 137.46 ? 171 LYS B C   1 
ATOM 2786 O O   . LYS B 2 171 ? 248.735 99.498  308.308 1.00 137.77 ? 171 LYS B O   1 
ATOM 2787 C CB  . LYS B 2 171 ? 251.498 98.087  307.134 1.00 140.45 ? 171 LYS B CB  1 
ATOM 2788 C CG  . LYS B 2 171 ? 252.240 96.758  307.225 1.00 143.85 ? 171 LYS B CG  1 
ATOM 2789 C CD  . LYS B 2 171 ? 253.759 96.918  307.230 1.00 147.02 ? 171 LYS B CD  1 
ATOM 2790 C CE  . LYS B 2 171 ? 254.526 95.619  307.244 1.00 148.98 ? 171 LYS B CE  1 
ATOM 2791 N NZ  . LYS B 2 171 ? 255.977 95.795  307.079 1.00 149.28 ? 171 LYS B NZ  1 
ATOM 2792 N N   . ASN B 2 172 ? 249.539 100.337 306.368 1.00 137.15 ? 172 ASN B N   1 
ATOM 2793 C CA  . ASN B 2 172 ? 249.158 101.714 306.644 1.00 137.57 ? 172 ASN B CA  1 
ATOM 2794 C C   . ASN B 2 172 ? 247.641 101.843 306.811 1.00 137.67 ? 172 ASN B C   1 
ATOM 2795 O O   . ASN B 2 172 ? 247.190 102.641 307.633 1.00 139.34 ? 172 ASN B O   1 
ATOM 2796 C CB  . ASN B 2 172 ? 249.684 102.663 305.572 1.00 137.07 ? 172 ASN B CB  1 
ATOM 2797 C CG  . ASN B 2 172 ? 249.425 104.111 305.915 1.00 138.63 ? 172 ASN B CG  1 
ATOM 2798 O OD1 . ASN B 2 172 ? 248.481 104.712 305.388 1.00 137.37 ? 172 ASN B OD1 1 
ATOM 2799 N ND2 . ASN B 2 172 ? 250.229 104.679 306.806 1.00 140.75 ? 172 ASN B ND2 1 
ATOM 2800 N N   . TYR B 2 173 ? 246.860 101.072 306.037 1.00 136.46 ? 173 TYR B N   1 
ATOM 2801 C CA  . TYR B 2 173 ? 245.404 101.140 306.097 1.00 136.80 ? 173 TYR B CA  1 
ATOM 2802 C C   . TYR B 2 173 ? 244.815 100.029 306.976 1.00 138.24 ? 173 TYR B C   1 
ATOM 2803 O O   . TYR B 2 173 ? 243.595 99.864  307.008 1.00 137.07 ? 173 TYR B O   1 
ATOM 2804 C CB  . TYR B 2 173 ? 244.851 101.109 304.668 1.00 135.07 ? 173 TYR B CB  1 
ATOM 2805 C CG  . TYR B 2 173 ? 245.042 102.433 303.942 1.00 134.13 ? 173 TYR B CG  1 
ATOM 2806 C CD1 . TYR B 2 173 ? 244.107 103.459 304.065 1.00 134.32 ? 173 TYR B CD1 1 
ATOM 2807 C CD2 . TYR B 2 173 ? 246.164 102.668 303.155 1.00 132.88 ? 173 TYR B CD2 1 
ATOM 2808 C CE1 . TYR B 2 173 ? 244.277 104.673 303.418 1.00 132.92 ? 173 TYR B CE1 1 
ATOM 2809 C CE2 . TYR B 2 173 ? 246.345 103.878 302.505 1.00 132.54 ? 173 TYR B CE2 1 
ATOM 2810 C CZ  . TYR B 2 173 ? 245.400 104.882 302.639 1.00 132.46 ? 173 TYR B CZ  1 
ATOM 2811 O OH  . TYR B 2 173 ? 245.560 106.082 302.011 1.00 133.90 ? 173 TYR B OH  1 
ATOM 2812 N N   . ASN B 2 174 ? 245.673 99.276  307.686 1.00 140.11 ? 174 ASN B N   1 
ATOM 2813 C CA  . ASN B 2 174 ? 245.264 98.248  308.640 1.00 142.49 ? 174 ASN B CA  1 
ATOM 2814 C C   . ASN B 2 174 ? 244.335 97.229  307.974 1.00 140.71 ? 174 ASN B C   1 
ATOM 2815 O O   . ASN B 2 174 ? 243.338 96.816  308.566 1.00 140.57 ? 174 ASN B O   1 
ATOM 2816 C CB  . ASN B 2 174 ? 244.652 98.849  309.907 1.00 145.83 ? 174 ASN B CB  1 
ATOM 2817 C CG  . ASN B 2 174 ? 245.662 99.618  310.735 1.00 149.64 ? 174 ASN B CG  1 
ATOM 2818 O OD1 . ASN B 2 174 ? 246.636 99.027  311.219 1.00 150.46 ? 174 ASN B OD1 1 
ATOM 2819 N ND2 . ASN B 2 174 ? 245.457 100.917 310.927 1.00 149.69 ? 174 ASN B ND2 1 
ATOM 2820 N N   . VAL B 2 175 ? 244.689 96.818  306.749 1.00 138.82 ? 175 VAL B N   1 
ATOM 2821 C CA  . VAL B 2 175 ? 243.928 95.835  305.995 1.00 138.32 ? 175 VAL B CA  1 
ATOM 2822 C C   . VAL B 2 175 ? 244.738 94.539  305.962 1.00 138.71 ? 175 VAL B C   1 
ATOM 2823 O O   . VAL B 2 175 ? 245.935 94.574  305.689 1.00 136.94 ? 175 VAL B O   1 
ATOM 2824 C CB  . VAL B 2 175 ? 243.592 96.342  304.575 1.00 138.49 ? 175 VAL B CB  1 
ATOM 2825 C CG1 . VAL B 2 175 ? 242.915 95.278  303.713 1.00 138.95 ? 175 VAL B CG1 1 
ATOM 2826 C CG2 . VAL B 2 175 ? 242.739 97.609  304.605 1.00 138.52 ? 175 VAL B CG2 1 
ATOM 2827 N N   . PRO B 2 176 ? 244.138 93.363  306.272 1.00 142.08 ? 176 PRO B N   1 
ATOM 2828 C CA  . PRO B 2 176 ? 244.837 92.083  306.116 1.00 142.82 ? 176 PRO B CA  1 
ATOM 2829 C C   . PRO B 2 176 ? 245.307 91.854  304.682 1.00 142.28 ? 176 PRO B C   1 
ATOM 2830 O O   . PRO B 2 176 ? 244.546 92.074  303.739 1.00 143.31 ? 176 PRO B O   1 
ATOM 2831 C CB  . PRO B 2 176 ? 243.796 91.029  306.545 1.00 143.92 ? 176 PRO B CB  1 
ATOM 2832 C CG  . PRO B 2 176 ? 242.815 91.794  307.415 1.00 144.82 ? 176 PRO B CG  1 
ATOM 2833 C CD  . PRO B 2 176 ? 242.785 93.198  306.835 1.00 143.74 ? 176 PRO B CD  1 
ATOM 2834 N N   . TYR B 2 177 ? 246.566 91.422  304.536 1.00 141.22 ? 177 TYR B N   1 
ATOM 2835 C CA  . TYR B 2 177 ? 247.090 90.987  303.251 1.00 141.18 ? 177 TYR B CA  1 
ATOM 2836 C C   . TYR B 2 177 ? 248.106 89.872  303.481 1.00 143.62 ? 177 TYR B C   1 
ATOM 2837 O O   . TYR B 2 177 ? 248.913 89.951  304.410 1.00 143.72 ? 177 TYR B O   1 
ATOM 2838 C CB  . TYR B 2 177 ? 247.746 92.128  302.463 1.00 138.04 ? 177 TYR B CB  1 
ATOM 2839 C CG  . TYR B 2 177 ? 248.336 91.710  301.122 1.00 135.47 ? 177 TYR B CG  1 
ATOM 2840 C CD1 . TYR B 2 177 ? 247.544 91.141  300.133 1.00 136.03 ? 177 TYR B CD1 1 
ATOM 2841 C CD2 . TYR B 2 177 ? 249.697 91.824  300.865 1.00 135.11 ? 177 TYR B CD2 1 
ATOM 2842 C CE1 . TYR B 2 177 ? 248.078 90.737  298.921 1.00 135.97 ? 177 TYR B CE1 1 
ATOM 2843 C CE2 . TYR B 2 177 ? 250.245 91.422  299.657 1.00 134.26 ? 177 TYR B CE2 1 
ATOM 2844 C CZ  . TYR B 2 177 ? 249.434 90.875  298.682 1.00 134.09 ? 177 TYR B CZ  1 
ATOM 2845 O OH  . TYR B 2 177 ? 249.971 90.478  297.492 1.00 133.29 ? 177 TYR B OH  1 
ATOM 2846 N N   . GLU B 2 178 ? 248.058 88.847  302.616 1.00 146.19 ? 178 GLU B N   1 
ATOM 2847 C CA  . GLU B 2 178 ? 249.064 87.798  302.599 1.00 149.75 ? 178 GLU B CA  1 
ATOM 2848 C C   . GLU B 2 178 ? 249.753 87.799  301.238 1.00 148.21 ? 178 GLU B C   1 
ATOM 2849 O O   . GLU B 2 178 ? 249.107 87.562  300.218 1.00 148.28 ? 178 GLU B O   1 
ATOM 2850 C CB  . GLU B 2 178 ? 248.469 86.425  302.919 1.00 154.24 ? 178 GLU B CB  1 
ATOM 2851 C CG  . GLU B 2 178 ? 248.008 86.287  304.371 1.00 158.68 ? 178 GLU B CG  1 
ATOM 2852 C CD  . GLU B 2 178 ? 247.767 84.864  304.860 1.00 163.45 ? 178 GLU B CD  1 
ATOM 2853 O OE1 . GLU B 2 178 ? 248.023 83.893  304.101 1.00 165.64 ? 178 GLU B OE1 1 
ATOM 2854 O OE2 . GLU B 2 178 ? 247.316 84.731  306.026 1.00 165.54 ? 178 GLU B OE2 1 
ATOM 2855 N N   . PRO B 2 179 ? 251.078 88.071  301.174 1.00 148.21 ? 179 PRO B N   1 
ATOM 2856 C CA  . PRO B 2 179 ? 251.775 88.162  299.890 1.00 149.10 ? 179 PRO B CA  1 
ATOM 2857 C C   . PRO B 2 179 ? 252.018 86.806  299.236 1.00 150.91 ? 179 PRO B C   1 
ATOM 2858 O O   . PRO B 2 179 ? 251.982 85.774  299.904 1.00 151.64 ? 179 PRO B O   1 
ATOM 2859 C CB  . PRO B 2 179 ? 253.088 88.871  300.264 1.00 148.44 ? 179 PRO B CB  1 
ATOM 2860 C CG  . PRO B 2 179 ? 253.352 88.432  301.686 1.00 148.17 ? 179 PRO B CG  1 
ATOM 2861 C CD  . PRO B 2 179 ? 251.973 88.321  302.319 1.00 148.18 ? 179 PRO B CD  1 
ATOM 2862 N N   . ASP B 2 180 ? 252.278 86.840  297.923 1.00 153.46 ? 180 ASP B N   1 
ATOM 2863 C CA  . ASP B 2 180 ? 252.490 85.638  297.135 1.00 156.34 ? 180 ASP B CA  1 
ATOM 2864 C C   . ASP B 2 180 ? 253.829 85.011  297.526 1.00 157.11 ? 180 ASP B C   1 
ATOM 2865 O O   . ASP B 2 180 ? 254.886 85.583  297.255 1.00 156.21 ? 180 ASP B O   1 
ATOM 2866 C CB  . ASP B 2 180 ? 252.391 85.928  295.643 1.00 157.66 ? 180 ASP B CB  1 
ATOM 2867 C CG  . ASP B 2 180 ? 252.503 84.722  294.717 1.00 160.59 ? 180 ASP B CG  1 
ATOM 2868 O OD1 . ASP B 2 180 ? 252.644 83.582  295.226 1.00 161.33 ? 180 ASP B OD1 1 
ATOM 2869 O OD2 . ASP B 2 180 ? 252.442 84.930  293.485 1.00 162.07 ? 180 ASP B OD2 1 
ATOM 2870 N N   . SER B 2 181 ? 253.759 83.822  298.145 1.00 158.20 ? 181 SER B N   1 
ATOM 2871 C CA  . SER B 2 181 ? 254.932 83.108  298.632 1.00 159.82 ? 181 SER B CA  1 
ATOM 2872 C C   . SER B 2 181 ? 255.899 82.777  297.491 1.00 159.58 ? 181 SER B C   1 
ATOM 2873 O O   . SER B 2 181 ? 257.111 82.761  297.705 1.00 158.90 ? 181 SER B O   1 
ATOM 2874 C CB  . SER B 2 181 ? 254.521 81.860  299.389 1.00 161.35 ? 181 SER B CB  1 
ATOM 2875 O OG  . SER B 2 181 ? 255.642 81.231  299.997 1.00 162.41 ? 181 SER B OG  1 
ATOM 2876 N N   . VAL B 2 182 ? 255.360 82.524  296.287 1.00 159.75 ? 182 VAL B N   1 
ATOM 2877 C CA  . VAL B 2 182 ? 256.163 82.173  295.119 1.00 160.99 ? 182 VAL B CA  1 
ATOM 2878 C C   . VAL B 2 182 ? 257.047 83.365  294.729 1.00 160.48 ? 182 VAL B C   1 
ATOM 2879 O O   . VAL B 2 182 ? 258.164 83.170  294.245 1.00 158.76 ? 182 VAL B O   1 
ATOM 2880 C CB  . VAL B 2 182 ? 255.279 81.692  293.941 1.00 162.18 ? 182 VAL B CB  1 
ATOM 2881 C CG1 . VAL B 2 182 ? 256.078 81.416  292.663 1.00 162.46 ? 182 VAL B CG1 1 
ATOM 2882 C CG2 . VAL B 2 182 ? 254.441 80.465  294.313 1.00 162.36 ? 182 VAL B CG2 1 
ATOM 2883 N N   . VAL B 2 183 ? 256.547 84.593  294.953 1.00 159.17 ? 183 VAL B N   1 
ATOM 2884 C CA  . VAL B 2 183 ? 257.287 85.812  294.652 1.00 157.02 ? 183 VAL B CA  1 
ATOM 2885 C C   . VAL B 2 183 ? 258.231 86.147  295.810 1.00 156.54 ? 183 VAL B C   1 
ATOM 2886 O O   . VAL B 2 183 ? 259.377 86.523  295.570 1.00 155.35 ? 183 VAL B O   1 
ATOM 2887 C CB  . VAL B 2 183 ? 256.340 86.990  294.330 1.00 155.31 ? 183 VAL B CB  1 
ATOM 2888 C CG1 . VAL B 2 183 ? 257.074 88.328  294.253 1.00 154.19 ? 183 VAL B CG1 1 
ATOM 2889 C CG2 . VAL B 2 183 ? 255.541 86.747  293.049 1.00 155.02 ? 183 VAL B CG2 1 
ATOM 2890 N N   . MET B 2 184 ? 257.752 86.018  297.057 1.00 157.47 ? 184 MET B N   1 
ATOM 2891 C CA  . MET B 2 184 ? 258.525 86.421  298.228 1.00 159.02 ? 184 MET B CA  1 
ATOM 2892 C C   . MET B 2 184 ? 259.741 85.509  298.436 1.00 161.77 ? 184 MET B C   1 
ATOM 2893 O O   . MET B 2 184 ? 260.687 85.901  299.126 1.00 160.87 ? 184 MET B O   1 
ATOM 2894 C CB  . MET B 2 184 ? 257.658 86.422  299.496 1.00 158.91 ? 184 MET B CB  1 
ATOM 2895 C CG  . MET B 2 184 ? 256.538 87.462  299.497 1.00 159.08 ? 184 MET B CG  1 
ATOM 2896 S SD  . MET B 2 184 ? 257.070 89.163  299.199 1.00 159.67 ? 184 MET B SD  1 
ATOM 2897 C CE  . MET B 2 184 ? 258.011 89.550  300.683 1.00 158.46 ? 184 MET B CE  1 
ATOM 2898 N N   . ALA B 2 185 ? 259.713 84.298  297.853 1.00 164.30 ? 185 ALA B N   1 
ATOM 2899 C CA  . ALA B 2 185 ? 260.849 83.380  297.876 1.00 165.85 ? 185 ALA B CA  1 
ATOM 2900 C C   . ALA B 2 185 ? 262.037 83.916  297.068 1.00 167.92 ? 185 ALA B C   1 
ATOM 2901 O O   . ALA B 2 185 ? 263.172 83.497  297.303 1.00 168.86 ? 185 ALA B O   1 
ATOM 2902 C CB  . ALA B 2 185 ? 260.414 82.018  297.364 1.00 165.20 ? 185 ALA B CB  1 
ATOM 2903 N N   . GLU B 2 186 ? 261.780 84.842  296.127 1.00 169.15 ? 186 GLU B N   1 
ATOM 2904 C CA  . GLU B 2 186 ? 262.811 85.396  295.255 1.00 170.65 ? 186 GLU B CA  1 
ATOM 2905 C C   . GLU B 2 186 ? 263.544 86.570  295.918 1.00 172.34 ? 186 GLU B C   1 
ATOM 2906 O O   . GLU B 2 186 ? 264.494 87.098  295.336 1.00 172.71 ? 186 GLU B O   1 
ATOM 2907 C CB  . GLU B 2 186 ? 262.218 85.868  293.923 1.00 171.50 ? 186 GLU B CB  1 
ATOM 2908 C CG  . GLU B 2 186 ? 261.471 84.789  293.139 1.00 173.01 ? 186 GLU B CG  1 
ATOM 2909 C CD  . GLU B 2 186 ? 260.932 85.252  291.793 1.00 174.56 ? 186 GLU B CD  1 
ATOM 2910 O OE1 . GLU B 2 186 ? 260.361 86.371  291.730 1.00 175.06 ? 186 GLU B OE1 1 
ATOM 2911 O OE2 . GLU B 2 186 ? 261.073 84.480  290.808 1.00 174.84 ? 186 GLU B OE2 1 
ATOM 2912 N N   . ALA B 2 187 ? 263.102 86.983  297.121 1.00 172.92 ? 187 ALA B N   1 
ATOM 2913 C CA  . ALA B 2 187 ? 263.715 88.082  297.860 1.00 173.64 ? 187 ALA B CA  1 
ATOM 2914 C C   . ALA B 2 187 ? 265.172 87.744  298.218 1.00 176.02 ? 187 ALA B C   1 
ATOM 2915 O O   . ALA B 2 187 ? 265.384 87.051  299.251 1.00 177.02 ? 187 ALA B O   1 
ATOM 2916 C CB  . ALA B 2 187 ? 262.890 88.399  299.100 1.00 172.37 ? 187 ALA B CB  1 
# 
