data_8V2C
# 
_entry.id   8V2C 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8V2C         pdb_00008v2c 10.2210/pdb8v2c/pdb 
WWPDB D_1000278760 ?            ?                   
EMDB  EMD-42905    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8V2C 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region' 
_pdbx_database_related.db_id          EMD-42905 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              matthew.franklin@regeneron.com 
_pdbx_contact_author.name_first         Matthew 
_pdbx_contact_author.name_last          Franklin 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1482-0136 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhou, Y.'       1 ? 
'Franklin, M.C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9776 
_citation.page_last                 9776 
_citation.title                     
'Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54124-1 
_citation.pdbx_database_id_PubMed   39532904 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhou, Y.'       1 0000-0002-1650-4591 
primary 'Stevis, P.E.'   2 ?                   
primary 'Cao, J.'        3 ?                   
primary 'Ehrlich, G.'    4 ?                   
primary 'Jones, J.'      5 ?                   
primary 'Rafique, A.'    6 0000-0003-4078-7242 
primary 'Sleeman, M.W.'  7 ?                   
primary 'Olson, W.C.'    8 ?                   
primary 'Franklin, M.C.' 9 0000-0002-1482-0136 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Oncostatin-M                                                                              20645.201 1 ? ? ? ? 
2 polymer     man 'Interleukin-6 receptor subunit beta'                                                     70033.594 1 ? ? ? ? 
3 polymer     man 'Oncostatin-M-specific receptor subunit beta'                                             82357.742 1 ? ? ? ? 
4 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   5 ? ? ? ? 
5 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose                                                  221.208   3 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;ANRGCSNSSSQLLSQLQNQANLTGNTESLLEPYIRLQNLNTPDLRAACTQHSVAFPSEDTLRQLSKPHFLSTVYTTLDRV
LYQLDALRQKFLKTPAFPKLDSARHNILGIRNNVFCMARLLNHSLEIPEPTQTDSGASRSTTTPDVFNTKIGSCGFLWGY
HRFMGSVGRVFREWDDGSTRSRR
;
;ANRGCSNSSSQLLSQLQNQANLTGNTESLLEPYIRLQNLNTPDLRAACTQHSVAFPSEDTLRQLSKPHFLSTVYTTLDRV
LYQLDALRQKFLKTPAFPKLDSARHNILGIRNNVFCMARLLNHSLEIPEPTQTDSGASRSTTTPDVFNTKIGSCGFLWGY
HRFMGSVGRVFREWDDGSTRSRR
;
A ? 
2 'polypeptide(L)' no no 
;QLLEPCGYIYPEFPVVQRGSNFTAICVLKEACLQHYYVNASYIVWKTNHAAVPREQVTVINRTTSSVTFTDVVLPSVQLT
CNILSFGQIEQNVYGVTMLSGFPPDKPTNLTCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCQSKHGTSCMV
SYMPTYYVNIEVWVEAENALGKVSSESINFDPVDKVKPTPPYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTK
DASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYEDRPSRPPSFWYKTNPSHGQEY
RSVRLIWKALPLSEANGKILDYEVILTQSKSVSQTYTVTGTELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVTAA
YSVVNLKAFPKDNLLWVEWTPPPKPVSKYILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGP
GGSESLKAYLKQAAPARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVVHVDSSHTEYTLSSLSS
DTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEEQKLISEEDLGGEQKLISEEDLHHHHHH
;
;QLLEPCGYIYPEFPVVQRGSNFTAICVLKEACLQHYYVNASYIVWKTNHAAVPREQVTVINRTTSSVTFTDVVLPSVQLT
CNILSFGQIEQNVYGVTMLSGFPPDKPTNLTCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCQSKHGTSCMV
SYMPTYYVNIEVWVEAENALGKVSSESINFDPVDKVKPTPPYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTK
DASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYEDRPSRPPSFWYKTNPSHGQEY
RSVRLIWKALPLSEANGKILDYEVILTQSKSVSQTYTVTGTELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVTAA
YSVVNLKAFPKDNLLWVEWTPPPKPVSKYILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGP
GGSESLKAYLKQAAPARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVVHVDSSHTEYTLSSLSS
DTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEEQKLISEEDLGGEQKLISEEDLHHHHHH
;
B ? 
3 'polypeptide(L)' no no 
;EVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDIP
LECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDE
PIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLT
WRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQDVTLKIIGA
TKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTP
ETAPSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRI
TTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTI
TSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKS
KEMQCNQPWERTLLPDNSVLCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHML
;
;EVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDIP
LECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDE
PIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLT
WRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQDVTLKIIGA
TKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTP
ETAPSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRI
TTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTI
TSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKS
KEMQCNQPWERTLLPDNSVLCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHML
;
C ? 
# 
_pdbx_entity_nonpoly.entity_id   5 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   ASN n 
1 3   ARG n 
1 4   GLY n 
1 5   CYS n 
1 6   SER n 
1 7   ASN n 
1 8   SER n 
1 9   SER n 
1 10  SER n 
1 11  GLN n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  GLN n 
1 16  LEU n 
1 17  GLN n 
1 18  ASN n 
1 19  GLN n 
1 20  ALA n 
1 21  ASN n 
1 22  LEU n 
1 23  THR n 
1 24  GLY n 
1 25  ASN n 
1 26  THR n 
1 27  GLU n 
1 28  SER n 
1 29  LEU n 
1 30  LEU n 
1 31  GLU n 
1 32  PRO n 
1 33  TYR n 
1 34  ILE n 
1 35  ARG n 
1 36  LEU n 
1 37  GLN n 
1 38  ASN n 
1 39  LEU n 
1 40  ASN n 
1 41  THR n 
1 42  PRO n 
1 43  ASP n 
1 44  LEU n 
1 45  ARG n 
1 46  ALA n 
1 47  ALA n 
1 48  CYS n 
1 49  THR n 
1 50  GLN n 
1 51  HIS n 
1 52  SER n 
1 53  VAL n 
1 54  ALA n 
1 55  PHE n 
1 56  PRO n 
1 57  SER n 
1 58  GLU n 
1 59  ASP n 
1 60  THR n 
1 61  LEU n 
1 62  ARG n 
1 63  GLN n 
1 64  LEU n 
1 65  SER n 
1 66  LYS n 
1 67  PRO n 
1 68  HIS n 
1 69  PHE n 
1 70  LEU n 
1 71  SER n 
1 72  THR n 
1 73  VAL n 
1 74  TYR n 
1 75  THR n 
1 76  THR n 
1 77  LEU n 
1 78  ASP n 
1 79  ARG n 
1 80  VAL n 
1 81  LEU n 
1 82  TYR n 
1 83  GLN n 
1 84  LEU n 
1 85  ASP n 
1 86  ALA n 
1 87  LEU n 
1 88  ARG n 
1 89  GLN n 
1 90  LYS n 
1 91  PHE n 
1 92  LEU n 
1 93  LYS n 
1 94  THR n 
1 95  PRO n 
1 96  ALA n 
1 97  PHE n 
1 98  PRO n 
1 99  LYS n 
1 100 LEU n 
1 101 ASP n 
1 102 SER n 
1 103 ALA n 
1 104 ARG n 
1 105 HIS n 
1 106 ASN n 
1 107 ILE n 
1 108 LEU n 
1 109 GLY n 
1 110 ILE n 
1 111 ARG n 
1 112 ASN n 
1 113 ASN n 
1 114 VAL n 
1 115 PHE n 
1 116 CYS n 
1 117 MET n 
1 118 ALA n 
1 119 ARG n 
1 120 LEU n 
1 121 LEU n 
1 122 ASN n 
1 123 HIS n 
1 124 SER n 
1 125 LEU n 
1 126 GLU n 
1 127 ILE n 
1 128 PRO n 
1 129 GLU n 
1 130 PRO n 
1 131 THR n 
1 132 GLN n 
1 133 THR n 
1 134 ASP n 
1 135 SER n 
1 136 GLY n 
1 137 ALA n 
1 138 SER n 
1 139 ARG n 
1 140 SER n 
1 141 THR n 
1 142 THR n 
1 143 THR n 
1 144 PRO n 
1 145 ASP n 
1 146 VAL n 
1 147 PHE n 
1 148 ASN n 
1 149 THR n 
1 150 LYS n 
1 151 ILE n 
1 152 GLY n 
1 153 SER n 
1 154 CYS n 
1 155 GLY n 
1 156 PHE n 
1 157 LEU n 
1 158 TRP n 
1 159 GLY n 
1 160 TYR n 
1 161 HIS n 
1 162 ARG n 
1 163 PHE n 
1 164 MET n 
1 165 GLY n 
1 166 SER n 
1 167 VAL n 
1 168 GLY n 
1 169 ARG n 
1 170 VAL n 
1 171 PHE n 
1 172 ARG n 
1 173 GLU n 
1 174 TRP n 
1 175 ASP n 
1 176 ASP n 
1 177 GLY n 
1 178 SER n 
1 179 THR n 
1 180 ARG n 
1 181 SER n 
1 182 ARG n 
1 183 ARG n 
2 1   GLN n 
2 2   LEU n 
2 3   LEU n 
2 4   GLU n 
2 5   PRO n 
2 6   CYS n 
2 7   GLY n 
2 8   TYR n 
2 9   ILE n 
2 10  TYR n 
2 11  PRO n 
2 12  GLU n 
2 13  PHE n 
2 14  PRO n 
2 15  VAL n 
2 16  VAL n 
2 17  GLN n 
2 18  ARG n 
2 19  GLY n 
2 20  SER n 
2 21  ASN n 
2 22  PHE n 
2 23  THR n 
2 24  ALA n 
2 25  ILE n 
2 26  CYS n 
2 27  VAL n 
2 28  LEU n 
2 29  LYS n 
2 30  GLU n 
2 31  ALA n 
2 32  CYS n 
2 33  LEU n 
2 34  GLN n 
2 35  HIS n 
2 36  TYR n 
2 37  TYR n 
2 38  VAL n 
2 39  ASN n 
2 40  ALA n 
2 41  SER n 
2 42  TYR n 
2 43  ILE n 
2 44  VAL n 
2 45  TRP n 
2 46  LYS n 
2 47  THR n 
2 48  ASN n 
2 49  HIS n 
2 50  ALA n 
2 51  ALA n 
2 52  VAL n 
2 53  PRO n 
2 54  ARG n 
2 55  GLU n 
2 56  GLN n 
2 57  VAL n 
2 58  THR n 
2 59  VAL n 
2 60  ILE n 
2 61  ASN n 
2 62  ARG n 
2 63  THR n 
2 64  THR n 
2 65  SER n 
2 66  SER n 
2 67  VAL n 
2 68  THR n 
2 69  PHE n 
2 70  THR n 
2 71  ASP n 
2 72  VAL n 
2 73  VAL n 
2 74  LEU n 
2 75  PRO n 
2 76  SER n 
2 77  VAL n 
2 78  GLN n 
2 79  LEU n 
2 80  THR n 
2 81  CYS n 
2 82  ASN n 
2 83  ILE n 
2 84  LEU n 
2 85  SER n 
2 86  PHE n 
2 87  GLY n 
2 88  GLN n 
2 89  ILE n 
2 90  GLU n 
2 91  GLN n 
2 92  ASN n 
2 93  VAL n 
2 94  TYR n 
2 95  GLY n 
2 96  VAL n 
2 97  THR n 
2 98  MET n 
2 99  LEU n 
2 100 SER n 
2 101 GLY n 
2 102 PHE n 
2 103 PRO n 
2 104 PRO n 
2 105 ASP n 
2 106 LYS n 
2 107 PRO n 
2 108 THR n 
2 109 ASN n 
2 110 LEU n 
2 111 THR n 
2 112 CYS n 
2 113 ILE n 
2 114 VAL n 
2 115 ASN n 
2 116 GLU n 
2 117 GLY n 
2 118 LYS n 
2 119 ASN n 
2 120 MET n 
2 121 LEU n 
2 122 CYS n 
2 123 GLN n 
2 124 TRP n 
2 125 ASP n 
2 126 PRO n 
2 127 GLY n 
2 128 ARG n 
2 129 GLU n 
2 130 THR n 
2 131 TYR n 
2 132 LEU n 
2 133 GLU n 
2 134 THR n 
2 135 ASN n 
2 136 TYR n 
2 137 THR n 
2 138 LEU n 
2 139 LYS n 
2 140 SER n 
2 141 GLU n 
2 142 TRP n 
2 143 ALA n 
2 144 THR n 
2 145 GLU n 
2 146 LYS n 
2 147 PHE n 
2 148 PRO n 
2 149 ASP n 
2 150 CYS n 
2 151 GLN n 
2 152 SER n 
2 153 LYS n 
2 154 HIS n 
2 155 GLY n 
2 156 THR n 
2 157 SER n 
2 158 CYS n 
2 159 MET n 
2 160 VAL n 
2 161 SER n 
2 162 TYR n 
2 163 MET n 
2 164 PRO n 
2 165 THR n 
2 166 TYR n 
2 167 TYR n 
2 168 VAL n 
2 169 ASN n 
2 170 ILE n 
2 171 GLU n 
2 172 VAL n 
2 173 TRP n 
2 174 VAL n 
2 175 GLU n 
2 176 ALA n 
2 177 GLU n 
2 178 ASN n 
2 179 ALA n 
2 180 LEU n 
2 181 GLY n 
2 182 LYS n 
2 183 VAL n 
2 184 SER n 
2 185 SER n 
2 186 GLU n 
2 187 SER n 
2 188 ILE n 
2 189 ASN n 
2 190 PHE n 
2 191 ASP n 
2 192 PRO n 
2 193 VAL n 
2 194 ASP n 
2 195 LYS n 
2 196 VAL n 
2 197 LYS n 
2 198 PRO n 
2 199 THR n 
2 200 PRO n 
2 201 PRO n 
2 202 TYR n 
2 203 ASN n 
2 204 LEU n 
2 205 SER n 
2 206 VAL n 
2 207 THR n 
2 208 ASN n 
2 209 SER n 
2 210 GLU n 
2 211 GLU n 
2 212 LEU n 
2 213 SER n 
2 214 SER n 
2 215 ILE n 
2 216 LEU n 
2 217 LYS n 
2 218 LEU n 
2 219 SER n 
2 220 TRP n 
2 221 VAL n 
2 222 SER n 
2 223 SER n 
2 224 GLY n 
2 225 LEU n 
2 226 GLY n 
2 227 GLY n 
2 228 LEU n 
2 229 LEU n 
2 230 ASP n 
2 231 LEU n 
2 232 LYS n 
2 233 SER n 
2 234 ASP n 
2 235 ILE n 
2 236 GLN n 
2 237 TYR n 
2 238 ARG n 
2 239 THR n 
2 240 LYS n 
2 241 ASP n 
2 242 ALA n 
2 243 SER n 
2 244 THR n 
2 245 TRP n 
2 246 ILE n 
2 247 GLN n 
2 248 VAL n 
2 249 PRO n 
2 250 LEU n 
2 251 GLU n 
2 252 ASP n 
2 253 THR n 
2 254 MET n 
2 255 SER n 
2 256 PRO n 
2 257 ARG n 
2 258 THR n 
2 259 SER n 
2 260 PHE n 
2 261 THR n 
2 262 VAL n 
2 263 GLN n 
2 264 ASP n 
2 265 LEU n 
2 266 LYS n 
2 267 PRO n 
2 268 PHE n 
2 269 THR n 
2 270 GLU n 
2 271 TYR n 
2 272 VAL n 
2 273 PHE n 
2 274 ARG n 
2 275 ILE n 
2 276 ARG n 
2 277 SER n 
2 278 ILE n 
2 279 LYS n 
2 280 ASP n 
2 281 SER n 
2 282 GLY n 
2 283 LYS n 
2 284 GLY n 
2 285 TYR n 
2 286 TRP n 
2 287 SER n 
2 288 ASP n 
2 289 TRP n 
2 290 SER n 
2 291 GLU n 
2 292 GLU n 
2 293 ALA n 
2 294 SER n 
2 295 GLY n 
2 296 THR n 
2 297 THR n 
2 298 TYR n 
2 299 GLU n 
2 300 ASP n 
2 301 ARG n 
2 302 PRO n 
2 303 SER n 
2 304 ARG n 
2 305 PRO n 
2 306 PRO n 
2 307 SER n 
2 308 PHE n 
2 309 TRP n 
2 310 TYR n 
2 311 LYS n 
2 312 THR n 
2 313 ASN n 
2 314 PRO n 
2 315 SER n 
2 316 HIS n 
2 317 GLY n 
2 318 GLN n 
2 319 GLU n 
2 320 TYR n 
2 321 ARG n 
2 322 SER n 
2 323 VAL n 
2 324 ARG n 
2 325 LEU n 
2 326 ILE n 
2 327 TRP n 
2 328 LYS n 
2 329 ALA n 
2 330 LEU n 
2 331 PRO n 
2 332 LEU n 
2 333 SER n 
2 334 GLU n 
2 335 ALA n 
2 336 ASN n 
2 337 GLY n 
2 338 LYS n 
2 339 ILE n 
2 340 LEU n 
2 341 ASP n 
2 342 TYR n 
2 343 GLU n 
2 344 VAL n 
2 345 ILE n 
2 346 LEU n 
2 347 THR n 
2 348 GLN n 
2 349 SER n 
2 350 LYS n 
2 351 SER n 
2 352 VAL n 
2 353 SER n 
2 354 GLN n 
2 355 THR n 
2 356 TYR n 
2 357 THR n 
2 358 VAL n 
2 359 THR n 
2 360 GLY n 
2 361 THR n 
2 362 GLU n 
2 363 LEU n 
2 364 THR n 
2 365 VAL n 
2 366 ASN n 
2 367 LEU n 
2 368 THR n 
2 369 ASN n 
2 370 ASP n 
2 371 ARG n 
2 372 TYR n 
2 373 VAL n 
2 374 ALA n 
2 375 SER n 
2 376 LEU n 
2 377 ALA n 
2 378 ALA n 
2 379 ARG n 
2 380 ASN n 
2 381 LYS n 
2 382 VAL n 
2 383 GLY n 
2 384 LYS n 
2 385 SER n 
2 386 ALA n 
2 387 ALA n 
2 388 ALA n 
2 389 VAL n 
2 390 LEU n 
2 391 THR n 
2 392 ILE n 
2 393 PRO n 
2 394 SER n 
2 395 PRO n 
2 396 HIS n 
2 397 VAL n 
2 398 THR n 
2 399 ALA n 
2 400 ALA n 
2 401 TYR n 
2 402 SER n 
2 403 VAL n 
2 404 VAL n 
2 405 ASN n 
2 406 LEU n 
2 407 LYS n 
2 408 ALA n 
2 409 PHE n 
2 410 PRO n 
2 411 LYS n 
2 412 ASP n 
2 413 ASN n 
2 414 LEU n 
2 415 LEU n 
2 416 TRP n 
2 417 VAL n 
2 418 GLU n 
2 419 TRP n 
2 420 THR n 
2 421 PRO n 
2 422 PRO n 
2 423 PRO n 
2 424 LYS n 
2 425 PRO n 
2 426 VAL n 
2 427 SER n 
2 428 LYS n 
2 429 TYR n 
2 430 ILE n 
2 431 LEU n 
2 432 GLU n 
2 433 TRP n 
2 434 CYS n 
2 435 VAL n 
2 436 LEU n 
2 437 SER n 
2 438 GLU n 
2 439 ASN n 
2 440 ALA n 
2 441 PRO n 
2 442 CYS n 
2 443 VAL n 
2 444 GLU n 
2 445 ASP n 
2 446 TRP n 
2 447 GLN n 
2 448 GLN n 
2 449 GLU n 
2 450 ASP n 
2 451 ALA n 
2 452 THR n 
2 453 VAL n 
2 454 ASN n 
2 455 ARG n 
2 456 THR n 
2 457 HIS n 
2 458 LEU n 
2 459 ARG n 
2 460 GLY n 
2 461 ARG n 
2 462 LEU n 
2 463 LEU n 
2 464 GLU n 
2 465 SER n 
2 466 LYS n 
2 467 CYS n 
2 468 TYR n 
2 469 GLN n 
2 470 ILE n 
2 471 THR n 
2 472 VAL n 
2 473 THR n 
2 474 PRO n 
2 475 VAL n 
2 476 PHE n 
2 477 ALA n 
2 478 THR n 
2 479 GLY n 
2 480 PRO n 
2 481 GLY n 
2 482 GLY n 
2 483 SER n 
2 484 GLU n 
2 485 SER n 
2 486 LEU n 
2 487 LYS n 
2 488 ALA n 
2 489 TYR n 
2 490 LEU n 
2 491 LYS n 
2 492 GLN n 
2 493 ALA n 
2 494 ALA n 
2 495 PRO n 
2 496 ALA n 
2 497 ARG n 
2 498 GLY n 
2 499 PRO n 
2 500 THR n 
2 501 VAL n 
2 502 ARG n 
2 503 THR n 
2 504 LYS n 
2 505 LYS n 
2 506 VAL n 
2 507 GLY n 
2 508 LYS n 
2 509 ASN n 
2 510 GLU n 
2 511 ALA n 
2 512 VAL n 
2 513 LEU n 
2 514 ALA n 
2 515 TRP n 
2 516 ASP n 
2 517 GLN n 
2 518 ILE n 
2 519 PRO n 
2 520 VAL n 
2 521 ASP n 
2 522 ASP n 
2 523 GLN n 
2 524 ASN n 
2 525 GLY n 
2 526 PHE n 
2 527 ILE n 
2 528 ARG n 
2 529 ASN n 
2 530 TYR n 
2 531 SER n 
2 532 ILE n 
2 533 SER n 
2 534 TYR n 
2 535 ARG n 
2 536 THR n 
2 537 SER n 
2 538 VAL n 
2 539 GLY n 
2 540 LYS n 
2 541 GLU n 
2 542 MET n 
2 543 VAL n 
2 544 VAL n 
2 545 HIS n 
2 546 VAL n 
2 547 ASP n 
2 548 SER n 
2 549 SER n 
2 550 HIS n 
2 551 THR n 
2 552 GLU n 
2 553 TYR n 
2 554 THR n 
2 555 LEU n 
2 556 SER n 
2 557 SER n 
2 558 LEU n 
2 559 SER n 
2 560 SER n 
2 561 ASP n 
2 562 THR n 
2 563 LEU n 
2 564 TYR n 
2 565 MET n 
2 566 VAL n 
2 567 ARG n 
2 568 MET n 
2 569 ALA n 
2 570 ALA n 
2 571 TYR n 
2 572 THR n 
2 573 ASP n 
2 574 GLU n 
2 575 GLY n 
2 576 GLY n 
2 577 LYS n 
2 578 ASP n 
2 579 GLY n 
2 580 PRO n 
2 581 GLU n 
2 582 PHE n 
2 583 THR n 
2 584 PHE n 
2 585 THR n 
2 586 THR n 
2 587 PRO n 
2 588 LYS n 
2 589 PHE n 
2 590 ALA n 
2 591 GLN n 
2 592 GLY n 
2 593 GLU n 
2 594 ILE n 
2 595 GLU n 
2 596 GLU n 
2 597 GLN n 
2 598 LYS n 
2 599 LEU n 
2 600 ILE n 
2 601 SER n 
2 602 GLU n 
2 603 GLU n 
2 604 ASP n 
2 605 LEU n 
2 606 GLY n 
2 607 GLY n 
2 608 GLU n 
2 609 GLN n 
2 610 LYS n 
2 611 LEU n 
2 612 ILE n 
2 613 SER n 
2 614 GLU n 
2 615 GLU n 
2 616 ASP n 
2 617 LEU n 
2 618 HIS n 
2 619 HIS n 
2 620 HIS n 
2 621 HIS n 
2 622 HIS n 
2 623 HIS n 
3 1   GLU n 
3 2   VAL n 
3 3   LEU n 
3 4   GLU n 
3 5   GLU n 
3 6   PRO n 
3 7   LEU n 
3 8   PRO n 
3 9   LEU n 
3 10  THR n 
3 11  PRO n 
3 12  GLU n 
3 13  ILE n 
3 14  HIS n 
3 15  LYS n 
3 16  VAL n 
3 17  SER n 
3 18  PHE n 
3 19  GLN n 
3 20  LEU n 
3 21  LYS n 
3 22  LEU n 
3 23  GLN n 
3 24  GLU n 
3 25  VAL n 
3 26  ASN n 
3 27  LEU n 
3 28  GLU n 
3 29  TRP n 
3 30  THR n 
3 31  VAL n 
3 32  PRO n 
3 33  ALA n 
3 34  LEU n 
3 35  THR n 
3 36  HIS n 
3 37  GLU n 
3 38  GLU n 
3 39  LEU n 
3 40  ASN n 
3 41  MET n 
3 42  ILE n 
3 43  PHE n 
3 44  GLN n 
3 45  ILE n 
3 46  GLU n 
3 47  ILE n 
3 48  SER n 
3 49  ARG n 
3 50  LEU n 
3 51  ASN n 
3 52  ILE n 
3 53  SER n 
3 54  ASN n 
3 55  THR n 
3 56  ILE n 
3 57  TRP n 
3 58  VAL n 
3 59  GLU n 
3 60  ASN n 
3 61  TYR n 
3 62  SER n 
3 63  THR n 
3 64  THR n 
3 65  VAL n 
3 66  LYS n 
3 67  ARG n 
3 68  GLU n 
3 69  GLU n 
3 70  ALA n 
3 71  VAL n 
3 72  ARG n 
3 73  TRP n 
3 74  ASN n 
3 75  TRP n 
3 76  THR n 
3 77  SER n 
3 78  ASP n 
3 79  ILE n 
3 80  PRO n 
3 81  LEU n 
3 82  GLU n 
3 83  CYS n 
3 84  VAL n 
3 85  LYS n 
3 86  HIS n 
3 87  PHE n 
3 88  ILE n 
3 89  ARG n 
3 90  ILE n 
3 91  ARG n 
3 92  ALA n 
3 93  LEU n 
3 94  VAL n 
3 95  ASP n 
3 96  ASP n 
3 97  THR n 
3 98  LYS n 
3 99  SER n 
3 100 LEU n 
3 101 PRO n 
3 102 GLN n 
3 103 SER n 
3 104 SER n 
3 105 TRP n 
3 106 GLY n 
3 107 ASN n 
3 108 TRP n 
3 109 SER n 
3 110 SER n 
3 111 TRP n 
3 112 LYS n 
3 113 GLU n 
3 114 VAL n 
3 115 ASN n 
3 116 ALA n 
3 117 LYS n 
3 118 VAL n 
3 119 SER n 
3 120 VAL n 
3 121 GLU n 
3 122 PRO n 
3 123 ASP n 
3 124 LYS n 
3 125 SER n 
3 126 LEU n 
3 127 ILE n 
3 128 PHE n 
3 129 PRO n 
3 130 LYS n 
3 131 ASP n 
3 132 LYS n 
3 133 VAL n 
3 134 LEU n 
3 135 GLU n 
3 136 GLU n 
3 137 GLY n 
3 138 SER n 
3 139 ASN n 
3 140 VAL n 
3 141 THR n 
3 142 ILE n 
3 143 CYS n 
3 144 LEU n 
3 145 MET n 
3 146 TYR n 
3 147 GLY n 
3 148 GLN n 
3 149 ASN n 
3 150 VAL n 
3 151 TYR n 
3 152 ASN n 
3 153 VAL n 
3 154 SER n 
3 155 CYS n 
3 156 LYS n 
3 157 LEU n 
3 158 GLN n 
3 159 ASP n 
3 160 GLU n 
3 161 PRO n 
3 162 ILE n 
3 163 HIS n 
3 164 GLY n 
3 165 GLU n 
3 166 GLN n 
3 167 LEU n 
3 168 ASP n 
3 169 SER n 
3 170 HIS n 
3 171 VAL n 
3 172 SER n 
3 173 LEU n 
3 174 LEU n 
3 175 LYS n 
3 176 LEU n 
3 177 ASN n 
3 178 ASN n 
3 179 VAL n 
3 180 VAL n 
3 181 PHE n 
3 182 LEU n 
3 183 SER n 
3 184 ASP n 
3 185 THR n 
3 186 GLY n 
3 187 THR n 
3 188 ASN n 
3 189 ILE n 
3 190 ASN n 
3 191 CYS n 
3 192 GLN n 
3 193 ALA n 
3 194 THR n 
3 195 LYS n 
3 196 GLY n 
3 197 PRO n 
3 198 LYS n 
3 199 ARG n 
3 200 ILE n 
3 201 PHE n 
3 202 GLY n 
3 203 THR n 
3 204 VAL n 
3 205 LEU n 
3 206 PHE n 
3 207 VAL n 
3 208 SER n 
3 209 LYS n 
3 210 VAL n 
3 211 LEU n 
3 212 GLU n 
3 213 GLU n 
3 214 PRO n 
3 215 LYS n 
3 216 ASN n 
3 217 VAL n 
3 218 SER n 
3 219 CYS n 
3 220 GLU n 
3 221 THR n 
3 222 ARG n 
3 223 ASP n 
3 224 PHE n 
3 225 LYS n 
3 226 THR n 
3 227 LEU n 
3 228 ASP n 
3 229 CYS n 
3 230 SER n 
3 231 TRP n 
3 232 GLU n 
3 233 PRO n 
3 234 GLY n 
3 235 VAL n 
3 236 ASP n 
3 237 THR n 
3 238 THR n 
3 239 LEU n 
3 240 THR n 
3 241 TRP n 
3 242 ARG n 
3 243 LYS n 
3 244 GLN n 
3 245 ARG n 
3 246 PHE n 
3 247 GLN n 
3 248 ASN n 
3 249 TYR n 
3 250 THR n 
3 251 LEU n 
3 252 CYS n 
3 253 GLU n 
3 254 SER n 
3 255 PHE n 
3 256 SER n 
3 257 LYS n 
3 258 ARG n 
3 259 CYS n 
3 260 GLU n 
3 261 VAL n 
3 262 SER n 
3 263 ASN n 
3 264 TYR n 
3 265 ARG n 
3 266 ASN n 
3 267 SER n 
3 268 TYR n 
3 269 THR n 
3 270 TRP n 
3 271 GLN n 
3 272 ILE n 
3 273 THR n 
3 274 GLU n 
3 275 GLY n 
3 276 SER n 
3 277 GLN n 
3 278 GLU n 
3 279 MET n 
3 280 TYR n 
3 281 ASN n 
3 282 PHE n 
3 283 THR n 
3 284 LEU n 
3 285 THR n 
3 286 ALA n 
3 287 GLU n 
3 288 ASN n 
3 289 GLN n 
3 290 LEU n 
3 291 ARG n 
3 292 LYS n 
3 293 ARG n 
3 294 SER n 
3 295 VAL n 
3 296 ASN n 
3 297 ILE n 
3 298 ASN n 
3 299 PHE n 
3 300 ASN n 
3 301 LEU n 
3 302 THR n 
3 303 HIS n 
3 304 ARG n 
3 305 VAL n 
3 306 HIS n 
3 307 PRO n 
3 308 LYS n 
3 309 ALA n 
3 310 PRO n 
3 311 GLN n 
3 312 ASP n 
3 313 VAL n 
3 314 THR n 
3 315 LEU n 
3 316 LYS n 
3 317 ILE n 
3 318 ILE n 
3 319 GLY n 
3 320 ALA n 
3 321 THR n 
3 322 LYS n 
3 323 ALA n 
3 324 ASN n 
3 325 MET n 
3 326 THR n 
3 327 TRP n 
3 328 LYS n 
3 329 VAL n 
3 330 HIS n 
3 331 SER n 
3 332 HIS n 
3 333 GLY n 
3 334 ASN n 
3 335 ASN n 
3 336 TYR n 
3 337 THR n 
3 338 LEU n 
3 339 LEU n 
3 340 CYS n 
3 341 GLN n 
3 342 VAL n 
3 343 LYS n 
3 344 LEU n 
3 345 GLN n 
3 346 TYR n 
3 347 GLY n 
3 348 GLU n 
3 349 VAL n 
3 350 ILE n 
3 351 HIS n 
3 352 GLU n 
3 353 HIS n 
3 354 ASN n 
3 355 VAL n 
3 356 SER n 
3 357 VAL n 
3 358 HIS n 
3 359 MET n 
3 360 SER n 
3 361 ALA n 
3 362 ASN n 
3 363 TYR n 
3 364 LEU n 
3 365 PHE n 
3 366 SER n 
3 367 ASP n 
3 368 LEU n 
3 369 ASP n 
3 370 PRO n 
3 371 ASP n 
3 372 THR n 
3 373 LYS n 
3 374 TYR n 
3 375 LYS n 
3 376 ALA n 
3 377 PHE n 
3 378 VAL n 
3 379 ARG n 
3 380 CYS n 
3 381 ALA n 
3 382 SER n 
3 383 ALA n 
3 384 ASN n 
3 385 HIS n 
3 386 PHE n 
3 387 TRP n 
3 388 LYS n 
3 389 TRP n 
3 390 SER n 
3 391 ASP n 
3 392 TRP n 
3 393 THR n 
3 394 GLN n 
3 395 LYS n 
3 396 GLU n 
3 397 PHE n 
3 398 SER n 
3 399 THR n 
3 400 PRO n 
3 401 GLU n 
3 402 THR n 
3 403 ALA n 
3 404 PRO n 
3 405 SER n 
3 406 GLN n 
3 407 ALA n 
3 408 LEU n 
3 409 ASP n 
3 410 VAL n 
3 411 TRP n 
3 412 ARG n 
3 413 GLN n 
3 414 VAL n 
3 415 TRP n 
3 416 SER n 
3 417 GLU n 
3 418 ASN n 
3 419 GLY n 
3 420 ARG n 
3 421 ARG n 
3 422 ILE n 
3 423 VAL n 
3 424 THR n 
3 425 LEU n 
3 426 PHE n 
3 427 TRP n 
3 428 LYS n 
3 429 PRO n 
3 430 LEU n 
3 431 LEU n 
3 432 LYS n 
3 433 SER n 
3 434 GLN n 
3 435 ALA n 
3 436 ASN n 
3 437 GLY n 
3 438 LYS n 
3 439 ILE n 
3 440 ILE n 
3 441 SER n 
3 442 TYR n 
3 443 ASN n 
3 444 ILE n 
3 445 VAL n 
3 446 VAL n 
3 447 GLU n 
3 448 ASN n 
3 449 GLU n 
3 450 ALA n 
3 451 LYS n 
3 452 PRO n 
3 453 THR n 
3 454 GLU n 
3 455 SER n 
3 456 GLU n 
3 457 HIS n 
3 458 TYR n 
3 459 CYS n 
3 460 VAL n 
3 461 TRP n 
3 462 ALA n 
3 463 PRO n 
3 464 ALA n 
3 465 LEU n 
3 466 SER n 
3 467 THR n 
3 468 ASN n 
3 469 LEU n 
3 470 SER n 
3 471 LEU n 
3 472 ASP n 
3 473 LEU n 
3 474 GLN n 
3 475 PRO n 
3 476 TYR n 
3 477 LYS n 
3 478 ILE n 
3 479 ARG n 
3 480 ILE n 
3 481 THR n 
3 482 THR n 
3 483 ASN n 
3 484 ASN n 
3 485 SER n 
3 486 MET n 
3 487 GLY n 
3 488 ALA n 
3 489 SER n 
3 490 PRO n 
3 491 GLU n 
3 492 SER n 
3 493 LEU n 
3 494 MET n 
3 495 VAL n 
3 496 LEU n 
3 497 SER n 
3 498 ASN n 
3 499 ASP n 
3 500 SER n 
3 501 GLY n 
3 502 HIS n 
3 503 GLU n 
3 504 GLU n 
3 505 VAL n 
3 506 LYS n 
3 507 GLU n 
3 508 LYS n 
3 509 THR n 
3 510 ILE n 
3 511 LYS n 
3 512 GLY n 
3 513 ILE n 
3 514 LYS n 
3 515 ASP n 
3 516 ALA n 
3 517 PHE n 
3 518 ASN n 
3 519 ILE n 
3 520 SER n 
3 521 TRP n 
3 522 GLU n 
3 523 PRO n 
3 524 VAL n 
3 525 SER n 
3 526 GLY n 
3 527 ASP n 
3 528 THR n 
3 529 MET n 
3 530 GLY n 
3 531 TYR n 
3 532 VAL n 
3 533 VAL n 
3 534 ASP n 
3 535 TRP n 
3 536 CYS n 
3 537 ALA n 
3 538 HIS n 
3 539 SER n 
3 540 GLN n 
3 541 ASP n 
3 542 GLN n 
3 543 ARG n 
3 544 CYS n 
3 545 ASP n 
3 546 LEU n 
3 547 GLN n 
3 548 TRP n 
3 549 LYS n 
3 550 ASN n 
3 551 LEU n 
3 552 GLY n 
3 553 PRO n 
3 554 ASN n 
3 555 THR n 
3 556 THR n 
3 557 SER n 
3 558 THR n 
3 559 THR n 
3 560 ILE n 
3 561 THR n 
3 562 SER n 
3 563 ASP n 
3 564 ASP n 
3 565 PHE n 
3 566 LYS n 
3 567 PRO n 
3 568 GLY n 
3 569 VAL n 
3 570 ARG n 
3 571 TYR n 
3 572 ASN n 
3 573 PHE n 
3 574 ARG n 
3 575 ILE n 
3 576 PHE n 
3 577 GLU n 
3 578 ARG n 
3 579 SER n 
3 580 VAL n 
3 581 GLU n 
3 582 HIS n 
3 583 LYS n 
3 584 ALA n 
3 585 ARG n 
3 586 LEU n 
3 587 VAL n 
3 588 GLU n 
3 589 LYS n 
3 590 GLN n 
3 591 ARG n 
3 592 GLY n 
3 593 TYR n 
3 594 THR n 
3 595 GLN n 
3 596 GLU n 
3 597 LEU n 
3 598 ALA n 
3 599 PRO n 
3 600 LEU n 
3 601 VAL n 
3 602 ASN n 
3 603 PRO n 
3 604 LYS n 
3 605 VAL n 
3 606 GLU n 
3 607 ILE n 
3 608 PRO n 
3 609 TYR n 
3 610 SER n 
3 611 THR n 
3 612 PRO n 
3 613 ASN n 
3 614 SER n 
3 615 PHE n 
3 616 VAL n 
3 617 LEU n 
3 618 ARG n 
3 619 TRP n 
3 620 PRO n 
3 621 ASP n 
3 622 TYR n 
3 623 ASP n 
3 624 SER n 
3 625 ASP n 
3 626 PHE n 
3 627 GLN n 
3 628 ALA n 
3 629 GLY n 
3 630 PHE n 
3 631 ILE n 
3 632 LYS n 
3 633 GLY n 
3 634 TYR n 
3 635 LEU n 
3 636 VAL n 
3 637 TYR n 
3 638 VAL n 
3 639 LYS n 
3 640 SER n 
3 641 LYS n 
3 642 GLU n 
3 643 MET n 
3 644 GLN n 
3 645 CYS n 
3 646 ASN n 
3 647 GLN n 
3 648 PRO n 
3 649 TRP n 
3 650 GLU n 
3 651 ARG n 
3 652 THR n 
3 653 LEU n 
3 654 LEU n 
3 655 PRO n 
3 656 ASP n 
3 657 ASN n 
3 658 SER n 
3 659 VAL n 
3 660 LEU n 
3 661 CYS n 
3 662 LYS n 
3 663 TYR n 
3 664 ASP n 
3 665 ILE n 
3 666 ASN n 
3 667 GLY n 
3 668 SER n 
3 669 GLU n 
3 670 THR n 
3 671 LYS n 
3 672 THR n 
3 673 LEU n 
3 674 THR n 
3 675 VAL n 
3 676 GLU n 
3 677 ASN n 
3 678 LEU n 
3 679 GLN n 
3 680 PRO n 
3 681 GLU n 
3 682 SER n 
3 683 LEU n 
3 684 TYR n 
3 685 GLU n 
3 686 PHE n 
3 687 PHE n 
3 688 VAL n 
3 689 THR n 
3 690 PRO n 
3 691 TYR n 
3 692 THR n 
3 693 SER n 
3 694 ALA n 
3 695 GLY n 
3 696 PRO n 
3 697 GLY n 
3 698 PRO n 
3 699 ASN n 
3 700 GLU n 
3 701 THR n 
3 702 PHE n 
3 703 THR n 
3 704 LYS n 
3 705 VAL n 
3 706 THR n 
3 707 THR n 
3 708 PRO n 
3 709 ASP n 
3 710 ALA n 
3 711 ARG n 
3 712 SER n 
3 713 HIS n 
3 714 MET n 
3 715 LEU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 183 'house mouse' ? Osm   ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 'Escherichia coli'   
562   ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 623 'house mouse' ? Il6st ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 
10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 715 'house mouse' ? Osmr  ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 'Homo sapiens'       
9606  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   4 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 4 DGlcpNAcb1-4DGlcpNAcb1-                               'Glycam Condensed Sequence' GMML       1.0   
2 4 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 4 '[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}}'    LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  4 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   24  24  ALA ALA A . n 
A 1 2   ASN 2   25  25  ASN ASN A . n 
A 1 3   ARG 3   26  26  ARG ARG A . n 
A 1 4   GLY 4   27  27  GLY GLY A . n 
A 1 5   CYS 5   28  28  CYS CYS A . n 
A 1 6   SER 6   29  29  SER SER A . n 
A 1 7   ASN 7   30  30  ASN ASN A . n 
A 1 8   SER 8   31  31  SER SER A . n 
A 1 9   SER 9   32  32  SER SER A . n 
A 1 10  SER 10  33  33  SER SER A . n 
A 1 11  GLN 11  34  34  GLN GLN A . n 
A 1 12  LEU 12  35  35  LEU LEU A . n 
A 1 13  LEU 13  36  36  LEU LEU A . n 
A 1 14  SER 14  37  37  SER SER A . n 
A 1 15  GLN 15  38  38  GLN GLN A . n 
A 1 16  LEU 16  39  39  LEU LEU A . n 
A 1 17  GLN 17  40  40  GLN GLN A . n 
A 1 18  ASN 18  41  41  ASN ASN A . n 
A 1 19  GLN 19  42  42  GLN GLN A . n 
A 1 20  ALA 20  43  43  ALA ALA A . n 
A 1 21  ASN 21  44  44  ASN ASN A . n 
A 1 22  LEU 22  45  45  LEU LEU A . n 
A 1 23  THR 23  46  46  THR THR A . n 
A 1 24  GLY 24  47  47  GLY GLY A . n 
A 1 25  ASN 25  48  48  ASN ASN A . n 
A 1 26  THR 26  49  49  THR THR A . n 
A 1 27  GLU 27  50  50  GLU GLU A . n 
A 1 28  SER 28  51  51  SER SER A . n 
A 1 29  LEU 29  52  52  LEU LEU A . n 
A 1 30  LEU 30  53  53  LEU LEU A . n 
A 1 31  GLU 31  54  54  GLU GLU A . n 
A 1 32  PRO 32  55  55  PRO PRO A . n 
A 1 33  TYR 33  56  56  TYR TYR A . n 
A 1 34  ILE 34  57  57  ILE ILE A . n 
A 1 35  ARG 35  58  58  ARG ARG A . n 
A 1 36  LEU 36  59  59  LEU LEU A . n 
A 1 37  GLN 37  60  60  GLN GLN A . n 
A 1 38  ASN 38  61  61  ASN ASN A . n 
A 1 39  LEU 39  62  62  LEU LEU A . n 
A 1 40  ASN 40  63  63  ASN ASN A . n 
A 1 41  THR 41  64  64  THR THR A . n 
A 1 42  PRO 42  65  65  PRO PRO A . n 
A 1 43  ASP 43  66  66  ASP ASP A . n 
A 1 44  LEU 44  67  67  LEU LEU A . n 
A 1 45  ARG 45  68  68  ARG ARG A . n 
A 1 46  ALA 46  69  69  ALA ALA A . n 
A 1 47  ALA 47  70  70  ALA ALA A . n 
A 1 48  CYS 48  71  71  CYS CYS A . n 
A 1 49  THR 49  72  72  THR THR A . n 
A 1 50  GLN 50  73  73  GLN GLN A . n 
A 1 51  HIS 51  74  74  HIS HIS A . n 
A 1 52  SER 52  75  75  SER SER A . n 
A 1 53  VAL 53  76  76  VAL VAL A . n 
A 1 54  ALA 54  77  77  ALA ALA A . n 
A 1 55  PHE 55  78  78  PHE PHE A . n 
A 1 56  PRO 56  79  79  PRO PRO A . n 
A 1 57  SER 57  80  80  SER SER A . n 
A 1 58  GLU 58  81  81  GLU GLU A . n 
A 1 59  ASP 59  82  82  ASP ASP A . n 
A 1 60  THR 60  83  83  THR THR A . n 
A 1 61  LEU 61  84  84  LEU LEU A . n 
A 1 62  ARG 62  85  85  ARG ARG A . n 
A 1 63  GLN 63  86  86  GLN GLN A . n 
A 1 64  LEU 64  87  87  LEU LEU A . n 
A 1 65  SER 65  88  88  SER SER A . n 
A 1 66  LYS 66  89  89  LYS LYS A . n 
A 1 67  PRO 67  90  90  PRO PRO A . n 
A 1 68  HIS 68  91  91  HIS HIS A . n 
A 1 69  PHE 69  92  92  PHE PHE A . n 
A 1 70  LEU 70  93  93  LEU LEU A . n 
A 1 71  SER 71  94  94  SER SER A . n 
A 1 72  THR 72  95  95  THR THR A . n 
A 1 73  VAL 73  96  96  VAL VAL A . n 
A 1 74  TYR 74  97  97  TYR TYR A . n 
A 1 75  THR 75  98  98  THR THR A . n 
A 1 76  THR 76  99  99  THR THR A . n 
A 1 77  LEU 77  100 100 LEU LEU A . n 
A 1 78  ASP 78  101 101 ASP ASP A . n 
A 1 79  ARG 79  102 102 ARG ARG A . n 
A 1 80  VAL 80  103 103 VAL VAL A . n 
A 1 81  LEU 81  104 104 LEU LEU A . n 
A 1 82  TYR 82  105 105 TYR TYR A . n 
A 1 83  GLN 83  106 106 GLN GLN A . n 
A 1 84  LEU 84  107 107 LEU LEU A . n 
A 1 85  ASP 85  108 108 ASP ASP A . n 
A 1 86  ALA 86  109 109 ALA ALA A . n 
A 1 87  LEU 87  110 110 LEU LEU A . n 
A 1 88  ARG 88  111 111 ARG ARG A . n 
A 1 89  GLN 89  112 112 GLN GLN A . n 
A 1 90  LYS 90  113 113 LYS LYS A . n 
A 1 91  PHE 91  114 114 PHE PHE A . n 
A 1 92  LEU 92  115 115 LEU LEU A . n 
A 1 93  LYS 93  116 116 LYS LYS A . n 
A 1 94  THR 94  117 117 THR THR A . n 
A 1 95  PRO 95  118 118 PRO PRO A . n 
A 1 96  ALA 96  119 119 ALA ALA A . n 
A 1 97  PHE 97  120 120 PHE PHE A . n 
A 1 98  PRO 98  121 121 PRO PRO A . n 
A 1 99  LYS 99  122 122 LYS LYS A . n 
A 1 100 LEU 100 123 123 LEU LEU A . n 
A 1 101 ASP 101 124 124 ASP ASP A . n 
A 1 102 SER 102 125 125 SER SER A . n 
A 1 103 ALA 103 126 126 ALA ALA A . n 
A 1 104 ARG 104 127 127 ARG ARG A . n 
A 1 105 HIS 105 128 128 HIS HIS A . n 
A 1 106 ASN 106 129 129 ASN ASN A . n 
A 1 107 ILE 107 130 130 ILE ILE A . n 
A 1 108 LEU 108 131 131 LEU LEU A . n 
A 1 109 GLY 109 132 132 GLY GLY A . n 
A 1 110 ILE 110 133 133 ILE ILE A . n 
A 1 111 ARG 111 134 134 ARG ARG A . n 
A 1 112 ASN 112 135 135 ASN ASN A . n 
A 1 113 ASN 113 136 136 ASN ASN A . n 
A 1 114 VAL 114 137 137 VAL VAL A . n 
A 1 115 PHE 115 138 138 PHE PHE A . n 
A 1 116 CYS 116 139 139 CYS CYS A . n 
A 1 117 MET 117 140 140 MET MET A . n 
A 1 118 ALA 118 141 141 ALA ALA A . n 
A 1 119 ARG 119 142 142 ARG ARG A . n 
A 1 120 LEU 120 143 143 LEU LEU A . n 
A 1 121 LEU 121 144 144 LEU LEU A . n 
A 1 122 ASN 122 145 145 ASN ASN A . n 
A 1 123 HIS 123 146 146 HIS HIS A . n 
A 1 124 SER 124 147 147 SER SER A . n 
A 1 125 LEU 125 148 148 LEU LEU A . n 
A 1 126 GLU 126 149 149 GLU GLU A . n 
A 1 127 ILE 127 150 150 ILE ILE A . n 
A 1 128 PRO 128 151 151 PRO PRO A . n 
A 1 129 GLU 129 152 ?   ?   ?   A . n 
A 1 130 PRO 130 153 ?   ?   ?   A . n 
A 1 131 THR 131 154 ?   ?   ?   A . n 
A 1 132 GLN 132 155 ?   ?   ?   A . n 
A 1 133 THR 133 156 ?   ?   ?   A . n 
A 1 134 ASP 134 157 ?   ?   ?   A . n 
A 1 135 SER 135 158 ?   ?   ?   A . n 
A 1 136 GLY 136 159 ?   ?   ?   A . n 
A 1 137 ALA 137 160 ?   ?   ?   A . n 
A 1 138 SER 138 161 ?   ?   ?   A . n 
A 1 139 ARG 139 162 162 ARG ARG A . n 
A 1 140 SER 140 163 163 SER SER A . n 
A 1 141 THR 141 164 164 THR THR A . n 
A 1 142 THR 142 165 165 THR THR A . n 
A 1 143 THR 143 166 166 THR THR A . n 
A 1 144 PRO 144 167 167 PRO PRO A . n 
A 1 145 ASP 145 168 168 ASP ASP A . n 
A 1 146 VAL 146 169 169 VAL VAL A . n 
A 1 147 PHE 147 170 170 PHE PHE A . n 
A 1 148 ASN 148 171 171 ASN ASN A . n 
A 1 149 THR 149 172 172 THR THR A . n 
A 1 150 LYS 150 173 173 LYS LYS A . n 
A 1 151 ILE 151 174 174 ILE ILE A . n 
A 1 152 GLY 152 175 175 GLY GLY A . n 
A 1 153 SER 153 176 176 SER SER A . n 
A 1 154 CYS 154 177 177 CYS CYS A . n 
A 1 155 GLY 155 178 178 GLY GLY A . n 
A 1 156 PHE 156 179 179 PHE PHE A . n 
A 1 157 LEU 157 180 180 LEU LEU A . n 
A 1 158 TRP 158 181 181 TRP TRP A . n 
A 1 159 GLY 159 182 182 GLY GLY A . n 
A 1 160 TYR 160 183 183 TYR TYR A . n 
A 1 161 HIS 161 184 184 HIS HIS A . n 
A 1 162 ARG 162 185 185 ARG ARG A . n 
A 1 163 PHE 163 186 186 PHE PHE A . n 
A 1 164 MET 164 187 187 MET MET A . n 
A 1 165 GLY 165 188 188 GLY GLY A . n 
A 1 166 SER 166 189 189 SER SER A . n 
A 1 167 VAL 167 190 190 VAL VAL A . n 
A 1 168 GLY 168 191 191 GLY GLY A . n 
A 1 169 ARG 169 192 192 ARG ARG A . n 
A 1 170 VAL 170 193 193 VAL VAL A . n 
A 1 171 PHE 171 194 194 PHE PHE A . n 
A 1 172 ARG 172 195 195 ARG ARG A . n 
A 1 173 GLU 173 196 196 GLU GLU A . n 
A 1 174 TRP 174 197 197 TRP TRP A . n 
A 1 175 ASP 175 198 198 ASP ASP A . n 
A 1 176 ASP 176 199 199 ASP ASP A . n 
A 1 177 GLY 177 200 200 GLY GLY A . n 
A 1 178 SER 178 201 201 SER SER A . n 
A 1 179 THR 179 202 202 THR THR A . n 
A 1 180 ARG 180 203 ?   ?   ?   A . n 
A 1 181 SER 181 204 ?   ?   ?   A . n 
A 1 182 ARG 182 205 ?   ?   ?   A . n 
A 1 183 ARG 183 206 ?   ?   ?   A . n 
B 2 1   GLN 1   23  ?   ?   ?   B . n 
B 2 2   LEU 2   24  ?   ?   ?   B . n 
B 2 3   LEU 3   25  ?   ?   ?   B . n 
B 2 4   GLU 4   26  ?   ?   ?   B . n 
B 2 5   PRO 5   27  ?   ?   ?   B . n 
B 2 6   CYS 6   28  ?   ?   ?   B . n 
B 2 7   GLY 7   29  ?   ?   ?   B . n 
B 2 8   TYR 8   30  ?   ?   ?   B . n 
B 2 9   ILE 9   31  ?   ?   ?   B . n 
B 2 10  TYR 10  32  ?   ?   ?   B . n 
B 2 11  PRO 11  33  ?   ?   ?   B . n 
B 2 12  GLU 12  34  ?   ?   ?   B . n 
B 2 13  PHE 13  35  ?   ?   ?   B . n 
B 2 14  PRO 14  36  ?   ?   ?   B . n 
B 2 15  VAL 15  37  ?   ?   ?   B . n 
B 2 16  VAL 16  38  ?   ?   ?   B . n 
B 2 17  GLN 17  39  ?   ?   ?   B . n 
B 2 18  ARG 18  40  ?   ?   ?   B . n 
B 2 19  GLY 19  41  ?   ?   ?   B . n 
B 2 20  SER 20  42  ?   ?   ?   B . n 
B 2 21  ASN 21  43  ?   ?   ?   B . n 
B 2 22  PHE 22  44  ?   ?   ?   B . n 
B 2 23  THR 23  45  ?   ?   ?   B . n 
B 2 24  ALA 24  46  ?   ?   ?   B . n 
B 2 25  ILE 25  47  ?   ?   ?   B . n 
B 2 26  CYS 26  48  ?   ?   ?   B . n 
B 2 27  VAL 27  49  ?   ?   ?   B . n 
B 2 28  LEU 28  50  ?   ?   ?   B . n 
B 2 29  LYS 29  51  ?   ?   ?   B . n 
B 2 30  GLU 30  52  ?   ?   ?   B . n 
B 2 31  ALA 31  53  ?   ?   ?   B . n 
B 2 32  CYS 32  54  ?   ?   ?   B . n 
B 2 33  LEU 33  55  ?   ?   ?   B . n 
B 2 34  GLN 34  56  ?   ?   ?   B . n 
B 2 35  HIS 35  57  ?   ?   ?   B . n 
B 2 36  TYR 36  58  ?   ?   ?   B . n 
B 2 37  TYR 37  59  ?   ?   ?   B . n 
B 2 38  VAL 38  60  ?   ?   ?   B . n 
B 2 39  ASN 39  61  ?   ?   ?   B . n 
B 2 40  ALA 40  62  ?   ?   ?   B . n 
B 2 41  SER 41  63  ?   ?   ?   B . n 
B 2 42  TYR 42  64  ?   ?   ?   B . n 
B 2 43  ILE 43  65  ?   ?   ?   B . n 
B 2 44  VAL 44  66  ?   ?   ?   B . n 
B 2 45  TRP 45  67  ?   ?   ?   B . n 
B 2 46  LYS 46  68  ?   ?   ?   B . n 
B 2 47  THR 47  69  ?   ?   ?   B . n 
B 2 48  ASN 48  70  ?   ?   ?   B . n 
B 2 49  HIS 49  71  ?   ?   ?   B . n 
B 2 50  ALA 50  72  ?   ?   ?   B . n 
B 2 51  ALA 51  73  ?   ?   ?   B . n 
B 2 52  VAL 52  74  ?   ?   ?   B . n 
B 2 53  PRO 53  75  ?   ?   ?   B . n 
B 2 54  ARG 54  76  ?   ?   ?   B . n 
B 2 55  GLU 55  77  ?   ?   ?   B . n 
B 2 56  GLN 56  78  ?   ?   ?   B . n 
B 2 57  VAL 57  79  ?   ?   ?   B . n 
B 2 58  THR 58  80  ?   ?   ?   B . n 
B 2 59  VAL 59  81  ?   ?   ?   B . n 
B 2 60  ILE 60  82  ?   ?   ?   B . n 
B 2 61  ASN 61  83  ?   ?   ?   B . n 
B 2 62  ARG 62  84  ?   ?   ?   B . n 
B 2 63  THR 63  85  ?   ?   ?   B . n 
B 2 64  THR 64  86  ?   ?   ?   B . n 
B 2 65  SER 65  87  ?   ?   ?   B . n 
B 2 66  SER 66  88  ?   ?   ?   B . n 
B 2 67  VAL 67  89  ?   ?   ?   B . n 
B 2 68  THR 68  90  ?   ?   ?   B . n 
B 2 69  PHE 69  91  ?   ?   ?   B . n 
B 2 70  THR 70  92  ?   ?   ?   B . n 
B 2 71  ASP 71  93  ?   ?   ?   B . n 
B 2 72  VAL 72  94  ?   ?   ?   B . n 
B 2 73  VAL 73  95  ?   ?   ?   B . n 
B 2 74  LEU 74  96  ?   ?   ?   B . n 
B 2 75  PRO 75  97  ?   ?   ?   B . n 
B 2 76  SER 76  98  ?   ?   ?   B . n 
B 2 77  VAL 77  99  ?   ?   ?   B . n 
B 2 78  GLN 78  100 ?   ?   ?   B . n 
B 2 79  LEU 79  101 ?   ?   ?   B . n 
B 2 80  THR 80  102 ?   ?   ?   B . n 
B 2 81  CYS 81  103 ?   ?   ?   B . n 
B 2 82  ASN 82  104 ?   ?   ?   B . n 
B 2 83  ILE 83  105 ?   ?   ?   B . n 
B 2 84  LEU 84  106 ?   ?   ?   B . n 
B 2 85  SER 85  107 ?   ?   ?   B . n 
B 2 86  PHE 86  108 ?   ?   ?   B . n 
B 2 87  GLY 87  109 ?   ?   ?   B . n 
B 2 88  GLN 88  110 ?   ?   ?   B . n 
B 2 89  ILE 89  111 ?   ?   ?   B . n 
B 2 90  GLU 90  112 ?   ?   ?   B . n 
B 2 91  GLN 91  113 ?   ?   ?   B . n 
B 2 92  ASN 92  114 ?   ?   ?   B . n 
B 2 93  VAL 93  115 ?   ?   ?   B . n 
B 2 94  TYR 94  116 ?   ?   ?   B . n 
B 2 95  GLY 95  117 ?   ?   ?   B . n 
B 2 96  VAL 96  118 ?   ?   ?   B . n 
B 2 97  THR 97  119 ?   ?   ?   B . n 
B 2 98  MET 98  120 ?   ?   ?   B . n 
B 2 99  LEU 99  121 ?   ?   ?   B . n 
B 2 100 SER 100 122 ?   ?   ?   B . n 
B 2 101 GLY 101 123 ?   ?   ?   B . n 
B 2 102 PHE 102 124 124 PHE PHE B . n 
B 2 103 PRO 103 125 125 PRO PRO B . n 
B 2 104 PRO 104 126 126 PRO PRO B . n 
B 2 105 ASP 105 127 127 ASP ASP B . n 
B 2 106 LYS 106 128 128 LYS LYS B . n 
B 2 107 PRO 107 129 129 PRO PRO B . n 
B 2 108 THR 108 130 130 THR THR B . n 
B 2 109 ASN 109 131 131 ASN ASN B . n 
B 2 110 LEU 110 132 132 LEU LEU B . n 
B 2 111 THR 111 133 133 THR THR B . n 
B 2 112 CYS 112 134 134 CYS CYS B . n 
B 2 113 ILE 113 135 135 ILE ILE B . n 
B 2 114 VAL 114 136 136 VAL VAL B . n 
B 2 115 ASN 115 137 137 ASN ASN B . n 
B 2 116 GLU 116 138 138 GLU GLU B . n 
B 2 117 GLY 117 139 139 GLY GLY B . n 
B 2 118 LYS 118 140 140 LYS LYS B . n 
B 2 119 ASN 119 141 141 ASN ASN B . n 
B 2 120 MET 120 142 142 MET MET B . n 
B 2 121 LEU 121 143 143 LEU LEU B . n 
B 2 122 CYS 122 144 144 CYS CYS B . n 
B 2 123 GLN 123 145 145 GLN GLN B . n 
B 2 124 TRP 124 146 146 TRP TRP B . n 
B 2 125 ASP 125 147 147 ASP ASP B . n 
B 2 126 PRO 126 148 148 PRO PRO B . n 
B 2 127 GLY 127 149 149 GLY GLY B . n 
B 2 128 ARG 128 150 150 ARG ARG B . n 
B 2 129 GLU 129 151 151 GLU GLU B . n 
B 2 130 THR 130 152 152 THR THR B . n 
B 2 131 TYR 131 153 153 TYR TYR B . n 
B 2 132 LEU 132 154 154 LEU LEU B . n 
B 2 133 GLU 133 155 155 GLU GLU B . n 
B 2 134 THR 134 156 156 THR THR B . n 
B 2 135 ASN 135 157 157 ASN ASN B . n 
B 2 136 TYR 136 158 158 TYR TYR B . n 
B 2 137 THR 137 159 159 THR THR B . n 
B 2 138 LEU 138 160 160 LEU LEU B . n 
B 2 139 LYS 139 161 161 LYS LYS B . n 
B 2 140 SER 140 162 162 SER SER B . n 
B 2 141 GLU 141 163 163 GLU GLU B . n 
B 2 142 TRP 142 164 164 TRP TRP B . n 
B 2 143 ALA 143 165 165 ALA ALA B . n 
B 2 144 THR 144 166 166 THR THR B . n 
B 2 145 GLU 145 167 167 GLU GLU B . n 
B 2 146 LYS 146 168 168 LYS LYS B . n 
B 2 147 PHE 147 169 169 PHE PHE B . n 
B 2 148 PRO 148 170 170 PRO PRO B . n 
B 2 149 ASP 149 171 171 ASP ASP B . n 
B 2 150 CYS 150 172 172 CYS CYS B . n 
B 2 151 GLN 151 173 173 GLN GLN B . n 
B 2 152 SER 152 174 174 SER SER B . n 
B 2 153 LYS 153 175 175 LYS LYS B . n 
B 2 154 HIS 154 176 176 HIS HIS B . n 
B 2 155 GLY 155 177 177 GLY GLY B . n 
B 2 156 THR 156 178 178 THR THR B . n 
B 2 157 SER 157 179 179 SER SER B . n 
B 2 158 CYS 158 180 180 CYS CYS B . n 
B 2 159 MET 159 181 181 MET MET B . n 
B 2 160 VAL 160 182 182 VAL VAL B . n 
B 2 161 SER 161 183 183 SER SER B . n 
B 2 162 TYR 162 184 184 TYR TYR B . n 
B 2 163 MET 163 185 185 MET MET B . n 
B 2 164 PRO 164 186 186 PRO PRO B . n 
B 2 165 THR 165 187 187 THR THR B . n 
B 2 166 TYR 166 188 188 TYR TYR B . n 
B 2 167 TYR 167 189 189 TYR TYR B . n 
B 2 168 VAL 168 190 190 VAL VAL B . n 
B 2 169 ASN 169 191 191 ASN ASN B . n 
B 2 170 ILE 170 192 192 ILE ILE B . n 
B 2 171 GLU 171 193 193 GLU GLU B . n 
B 2 172 VAL 172 194 194 VAL VAL B . n 
B 2 173 TRP 173 195 195 TRP TRP B . n 
B 2 174 VAL 174 196 196 VAL VAL B . n 
B 2 175 GLU 175 197 197 GLU GLU B . n 
B 2 176 ALA 176 198 198 ALA ALA B . n 
B 2 177 GLU 177 199 199 GLU GLU B . n 
B 2 178 ASN 178 200 200 ASN ASN B . n 
B 2 179 ALA 179 201 201 ALA ALA B . n 
B 2 180 LEU 180 202 202 LEU LEU B . n 
B 2 181 GLY 181 203 203 GLY GLY B . n 
B 2 182 LYS 182 204 204 LYS LYS B . n 
B 2 183 VAL 183 205 205 VAL VAL B . n 
B 2 184 SER 184 206 206 SER SER B . n 
B 2 185 SER 185 207 207 SER SER B . n 
B 2 186 GLU 186 208 208 GLU GLU B . n 
B 2 187 SER 187 209 209 SER SER B . n 
B 2 188 ILE 188 210 210 ILE ILE B . n 
B 2 189 ASN 189 211 211 ASN ASN B . n 
B 2 190 PHE 190 212 212 PHE PHE B . n 
B 2 191 ASP 191 213 213 ASP ASP B . n 
B 2 192 PRO 192 214 214 PRO PRO B . n 
B 2 193 VAL 193 215 215 VAL VAL B . n 
B 2 194 ASP 194 216 216 ASP ASP B . n 
B 2 195 LYS 195 217 217 LYS LYS B . n 
B 2 196 VAL 196 218 218 VAL VAL B . n 
B 2 197 LYS 197 219 219 LYS LYS B . n 
B 2 198 PRO 198 220 220 PRO PRO B . n 
B 2 199 THR 199 221 221 THR THR B . n 
B 2 200 PRO 200 222 222 PRO PRO B . n 
B 2 201 PRO 201 223 223 PRO PRO B . n 
B 2 202 TYR 202 224 224 TYR TYR B . n 
B 2 203 ASN 203 225 225 ASN ASN B . n 
B 2 204 LEU 204 226 226 LEU LEU B . n 
B 2 205 SER 205 227 227 SER SER B . n 
B 2 206 VAL 206 228 228 VAL VAL B . n 
B 2 207 THR 207 229 229 THR THR B . n 
B 2 208 ASN 208 230 230 ASN ASN B . n 
B 2 209 SER 209 231 231 SER SER B . n 
B 2 210 GLU 210 232 232 GLU GLU B . n 
B 2 211 GLU 211 233 233 GLU GLU B . n 
B 2 212 LEU 212 234 234 LEU LEU B . n 
B 2 213 SER 213 235 235 SER SER B . n 
B 2 214 SER 214 236 236 SER SER B . n 
B 2 215 ILE 215 237 237 ILE ILE B . n 
B 2 216 LEU 216 238 238 LEU LEU B . n 
B 2 217 LYS 217 239 239 LYS LYS B . n 
B 2 218 LEU 218 240 240 LEU LEU B . n 
B 2 219 SER 219 241 241 SER SER B . n 
B 2 220 TRP 220 242 242 TRP TRP B . n 
B 2 221 VAL 221 243 243 VAL VAL B . n 
B 2 222 SER 222 244 244 SER SER B . n 
B 2 223 SER 223 245 245 SER SER B . n 
B 2 224 GLY 224 246 246 GLY GLY B . n 
B 2 225 LEU 225 247 247 LEU LEU B . n 
B 2 226 GLY 226 248 248 GLY GLY B . n 
B 2 227 GLY 227 249 249 GLY GLY B . n 
B 2 228 LEU 228 250 250 LEU LEU B . n 
B 2 229 LEU 229 251 251 LEU LEU B . n 
B 2 230 ASP 230 252 252 ASP ASP B . n 
B 2 231 LEU 231 253 253 LEU LEU B . n 
B 2 232 LYS 232 254 254 LYS LYS B . n 
B 2 233 SER 233 255 255 SER SER B . n 
B 2 234 ASP 234 256 256 ASP ASP B . n 
B 2 235 ILE 235 257 257 ILE ILE B . n 
B 2 236 GLN 236 258 258 GLN GLN B . n 
B 2 237 TYR 237 259 259 TYR TYR B . n 
B 2 238 ARG 238 260 260 ARG ARG B . n 
B 2 239 THR 239 261 261 THR THR B . n 
B 2 240 LYS 240 262 262 LYS LYS B . n 
B 2 241 ASP 241 263 263 ASP ASP B . n 
B 2 242 ALA 242 264 264 ALA ALA B . n 
B 2 243 SER 243 265 265 SER SER B . n 
B 2 244 THR 244 266 266 THR THR B . n 
B 2 245 TRP 245 267 267 TRP TRP B . n 
B 2 246 ILE 246 268 268 ILE ILE B . n 
B 2 247 GLN 247 269 269 GLN GLN B . n 
B 2 248 VAL 248 270 270 VAL VAL B . n 
B 2 249 PRO 249 271 271 PRO PRO B . n 
B 2 250 LEU 250 272 272 LEU LEU B . n 
B 2 251 GLU 251 273 273 GLU GLU B . n 
B 2 252 ASP 252 274 274 ASP ASP B . n 
B 2 253 THR 253 275 275 THR THR B . n 
B 2 254 MET 254 276 276 MET MET B . n 
B 2 255 SER 255 277 277 SER SER B . n 
B 2 256 PRO 256 278 278 PRO PRO B . n 
B 2 257 ARG 257 279 279 ARG ARG B . n 
B 2 258 THR 258 280 280 THR THR B . n 
B 2 259 SER 259 281 281 SER SER B . n 
B 2 260 PHE 260 282 282 PHE PHE B . n 
B 2 261 THR 261 283 283 THR THR B . n 
B 2 262 VAL 262 284 284 VAL VAL B . n 
B 2 263 GLN 263 285 285 GLN GLN B . n 
B 2 264 ASP 264 286 286 ASP ASP B . n 
B 2 265 LEU 265 287 287 LEU LEU B . n 
B 2 266 LYS 266 288 288 LYS LYS B . n 
B 2 267 PRO 267 289 289 PRO PRO B . n 
B 2 268 PHE 268 290 290 PHE PHE B . n 
B 2 269 THR 269 291 291 THR THR B . n 
B 2 270 GLU 270 292 292 GLU GLU B . n 
B 2 271 TYR 271 293 293 TYR TYR B . n 
B 2 272 VAL 272 294 294 VAL VAL B . n 
B 2 273 PHE 273 295 295 PHE PHE B . n 
B 2 274 ARG 274 296 296 ARG ARG B . n 
B 2 275 ILE 275 297 297 ILE ILE B . n 
B 2 276 ARG 276 298 298 ARG ARG B . n 
B 2 277 SER 277 299 299 SER SER B . n 
B 2 278 ILE 278 300 300 ILE ILE B . n 
B 2 279 LYS 279 301 301 LYS LYS B . n 
B 2 280 ASP 280 302 302 ASP ASP B . n 
B 2 281 SER 281 303 303 SER SER B . n 
B 2 282 GLY 282 304 304 GLY GLY B . n 
B 2 283 LYS 283 305 305 LYS LYS B . n 
B 2 284 GLY 284 306 306 GLY GLY B . n 
B 2 285 TYR 285 307 307 TYR TYR B . n 
B 2 286 TRP 286 308 308 TRP TRP B . n 
B 2 287 SER 287 309 309 SER SER B . n 
B 2 288 ASP 288 310 310 ASP ASP B . n 
B 2 289 TRP 289 311 311 TRP TRP B . n 
B 2 290 SER 290 312 312 SER SER B . n 
B 2 291 GLU 291 313 313 GLU GLU B . n 
B 2 292 GLU 292 314 314 GLU GLU B . n 
B 2 293 ALA 293 315 315 ALA ALA B . n 
B 2 294 SER 294 316 316 SER SER B . n 
B 2 295 GLY 295 317 317 GLY GLY B . n 
B 2 296 THR 296 318 318 THR THR B . n 
B 2 297 THR 297 319 319 THR THR B . n 
B 2 298 TYR 298 320 320 TYR TYR B . n 
B 2 299 GLU 299 321 321 GLU GLU B . n 
B 2 300 ASP 300 322 ?   ?   ?   B . n 
B 2 301 ARG 301 323 ?   ?   ?   B . n 
B 2 302 PRO 302 324 ?   ?   ?   B . n 
B 2 303 SER 303 325 ?   ?   ?   B . n 
B 2 304 ARG 304 326 ?   ?   ?   B . n 
B 2 305 PRO 305 327 ?   ?   ?   B . n 
B 2 306 PRO 306 328 ?   ?   ?   B . n 
B 2 307 SER 307 329 ?   ?   ?   B . n 
B 2 308 PHE 308 330 ?   ?   ?   B . n 
B 2 309 TRP 309 331 ?   ?   ?   B . n 
B 2 310 TYR 310 332 ?   ?   ?   B . n 
B 2 311 LYS 311 333 ?   ?   ?   B . n 
B 2 312 THR 312 334 ?   ?   ?   B . n 
B 2 313 ASN 313 335 ?   ?   ?   B . n 
B 2 314 PRO 314 336 ?   ?   ?   B . n 
B 2 315 SER 315 337 ?   ?   ?   B . n 
B 2 316 HIS 316 338 ?   ?   ?   B . n 
B 2 317 GLY 317 339 ?   ?   ?   B . n 
B 2 318 GLN 318 340 ?   ?   ?   B . n 
B 2 319 GLU 319 341 ?   ?   ?   B . n 
B 2 320 TYR 320 342 ?   ?   ?   B . n 
B 2 321 ARG 321 343 ?   ?   ?   B . n 
B 2 322 SER 322 344 ?   ?   ?   B . n 
B 2 323 VAL 323 345 ?   ?   ?   B . n 
B 2 324 ARG 324 346 ?   ?   ?   B . n 
B 2 325 LEU 325 347 ?   ?   ?   B . n 
B 2 326 ILE 326 348 ?   ?   ?   B . n 
B 2 327 TRP 327 349 ?   ?   ?   B . n 
B 2 328 LYS 328 350 ?   ?   ?   B . n 
B 2 329 ALA 329 351 ?   ?   ?   B . n 
B 2 330 LEU 330 352 ?   ?   ?   B . n 
B 2 331 PRO 331 353 ?   ?   ?   B . n 
B 2 332 LEU 332 354 ?   ?   ?   B . n 
B 2 333 SER 333 355 ?   ?   ?   B . n 
B 2 334 GLU 334 356 ?   ?   ?   B . n 
B 2 335 ALA 335 357 ?   ?   ?   B . n 
B 2 336 ASN 336 358 ?   ?   ?   B . n 
B 2 337 GLY 337 359 ?   ?   ?   B . n 
B 2 338 LYS 338 360 ?   ?   ?   B . n 
B 2 339 ILE 339 361 ?   ?   ?   B . n 
B 2 340 LEU 340 362 ?   ?   ?   B . n 
B 2 341 ASP 341 363 ?   ?   ?   B . n 
B 2 342 TYR 342 364 ?   ?   ?   B . n 
B 2 343 GLU 343 365 ?   ?   ?   B . n 
B 2 344 VAL 344 366 ?   ?   ?   B . n 
B 2 345 ILE 345 367 ?   ?   ?   B . n 
B 2 346 LEU 346 368 ?   ?   ?   B . n 
B 2 347 THR 347 369 ?   ?   ?   B . n 
B 2 348 GLN 348 370 ?   ?   ?   B . n 
B 2 349 SER 349 371 ?   ?   ?   B . n 
B 2 350 LYS 350 372 ?   ?   ?   B . n 
B 2 351 SER 351 373 ?   ?   ?   B . n 
B 2 352 VAL 352 374 ?   ?   ?   B . n 
B 2 353 SER 353 375 ?   ?   ?   B . n 
B 2 354 GLN 354 376 ?   ?   ?   B . n 
B 2 355 THR 355 377 ?   ?   ?   B . n 
B 2 356 TYR 356 378 ?   ?   ?   B . n 
B 2 357 THR 357 379 ?   ?   ?   B . n 
B 2 358 VAL 358 380 ?   ?   ?   B . n 
B 2 359 THR 359 381 ?   ?   ?   B . n 
B 2 360 GLY 360 382 ?   ?   ?   B . n 
B 2 361 THR 361 383 ?   ?   ?   B . n 
B 2 362 GLU 362 384 ?   ?   ?   B . n 
B 2 363 LEU 363 385 ?   ?   ?   B . n 
B 2 364 THR 364 386 ?   ?   ?   B . n 
B 2 365 VAL 365 387 ?   ?   ?   B . n 
B 2 366 ASN 366 388 ?   ?   ?   B . n 
B 2 367 LEU 367 389 ?   ?   ?   B . n 
B 2 368 THR 368 390 ?   ?   ?   B . n 
B 2 369 ASN 369 391 ?   ?   ?   B . n 
B 2 370 ASP 370 392 ?   ?   ?   B . n 
B 2 371 ARG 371 393 ?   ?   ?   B . n 
B 2 372 TYR 372 394 ?   ?   ?   B . n 
B 2 373 VAL 373 395 ?   ?   ?   B . n 
B 2 374 ALA 374 396 ?   ?   ?   B . n 
B 2 375 SER 375 397 ?   ?   ?   B . n 
B 2 376 LEU 376 398 ?   ?   ?   B . n 
B 2 377 ALA 377 399 ?   ?   ?   B . n 
B 2 378 ALA 378 400 ?   ?   ?   B . n 
B 2 379 ARG 379 401 ?   ?   ?   B . n 
B 2 380 ASN 380 402 ?   ?   ?   B . n 
B 2 381 LYS 381 403 ?   ?   ?   B . n 
B 2 382 VAL 382 404 ?   ?   ?   B . n 
B 2 383 GLY 383 405 ?   ?   ?   B . n 
B 2 384 LYS 384 406 ?   ?   ?   B . n 
B 2 385 SER 385 407 ?   ?   ?   B . n 
B 2 386 ALA 386 408 ?   ?   ?   B . n 
B 2 387 ALA 387 409 ?   ?   ?   B . n 
B 2 388 ALA 388 410 ?   ?   ?   B . n 
B 2 389 VAL 389 411 ?   ?   ?   B . n 
B 2 390 LEU 390 412 ?   ?   ?   B . n 
B 2 391 THR 391 413 ?   ?   ?   B . n 
B 2 392 ILE 392 414 ?   ?   ?   B . n 
B 2 393 PRO 393 415 ?   ?   ?   B . n 
B 2 394 SER 394 416 ?   ?   ?   B . n 
B 2 395 PRO 395 417 ?   ?   ?   B . n 
B 2 396 HIS 396 418 ?   ?   ?   B . n 
B 2 397 VAL 397 419 ?   ?   ?   B . n 
B 2 398 THR 398 420 ?   ?   ?   B . n 
B 2 399 ALA 399 421 ?   ?   ?   B . n 
B 2 400 ALA 400 422 ?   ?   ?   B . n 
B 2 401 TYR 401 423 ?   ?   ?   B . n 
B 2 402 SER 402 424 ?   ?   ?   B . n 
B 2 403 VAL 403 425 ?   ?   ?   B . n 
B 2 404 VAL 404 426 ?   ?   ?   B . n 
B 2 405 ASN 405 427 ?   ?   ?   B . n 
B 2 406 LEU 406 428 ?   ?   ?   B . n 
B 2 407 LYS 407 429 ?   ?   ?   B . n 
B 2 408 ALA 408 430 ?   ?   ?   B . n 
B 2 409 PHE 409 431 ?   ?   ?   B . n 
B 2 410 PRO 410 432 ?   ?   ?   B . n 
B 2 411 LYS 411 433 ?   ?   ?   B . n 
B 2 412 ASP 412 434 ?   ?   ?   B . n 
B 2 413 ASN 413 435 ?   ?   ?   B . n 
B 2 414 LEU 414 436 ?   ?   ?   B . n 
B 2 415 LEU 415 437 ?   ?   ?   B . n 
B 2 416 TRP 416 438 ?   ?   ?   B . n 
B 2 417 VAL 417 439 ?   ?   ?   B . n 
B 2 418 GLU 418 440 ?   ?   ?   B . n 
B 2 419 TRP 419 441 ?   ?   ?   B . n 
B 2 420 THR 420 442 ?   ?   ?   B . n 
B 2 421 PRO 421 443 ?   ?   ?   B . n 
B 2 422 PRO 422 444 ?   ?   ?   B . n 
B 2 423 PRO 423 445 ?   ?   ?   B . n 
B 2 424 LYS 424 446 ?   ?   ?   B . n 
B 2 425 PRO 425 447 ?   ?   ?   B . n 
B 2 426 VAL 426 448 ?   ?   ?   B . n 
B 2 427 SER 427 449 ?   ?   ?   B . n 
B 2 428 LYS 428 450 ?   ?   ?   B . n 
B 2 429 TYR 429 451 ?   ?   ?   B . n 
B 2 430 ILE 430 452 ?   ?   ?   B . n 
B 2 431 LEU 431 453 ?   ?   ?   B . n 
B 2 432 GLU 432 454 ?   ?   ?   B . n 
B 2 433 TRP 433 455 ?   ?   ?   B . n 
B 2 434 CYS 434 456 ?   ?   ?   B . n 
B 2 435 VAL 435 457 ?   ?   ?   B . n 
B 2 436 LEU 436 458 ?   ?   ?   B . n 
B 2 437 SER 437 459 ?   ?   ?   B . n 
B 2 438 GLU 438 460 ?   ?   ?   B . n 
B 2 439 ASN 439 461 ?   ?   ?   B . n 
B 2 440 ALA 440 462 ?   ?   ?   B . n 
B 2 441 PRO 441 463 ?   ?   ?   B . n 
B 2 442 CYS 442 464 ?   ?   ?   B . n 
B 2 443 VAL 443 465 ?   ?   ?   B . n 
B 2 444 GLU 444 466 ?   ?   ?   B . n 
B 2 445 ASP 445 467 ?   ?   ?   B . n 
B 2 446 TRP 446 468 ?   ?   ?   B . n 
B 2 447 GLN 447 469 ?   ?   ?   B . n 
B 2 448 GLN 448 470 ?   ?   ?   B . n 
B 2 449 GLU 449 471 ?   ?   ?   B . n 
B 2 450 ASP 450 472 ?   ?   ?   B . n 
B 2 451 ALA 451 473 ?   ?   ?   B . n 
B 2 452 THR 452 474 ?   ?   ?   B . n 
B 2 453 VAL 453 475 ?   ?   ?   B . n 
B 2 454 ASN 454 476 ?   ?   ?   B . n 
B 2 455 ARG 455 477 ?   ?   ?   B . n 
B 2 456 THR 456 478 ?   ?   ?   B . n 
B 2 457 HIS 457 479 ?   ?   ?   B . n 
B 2 458 LEU 458 480 ?   ?   ?   B . n 
B 2 459 ARG 459 481 ?   ?   ?   B . n 
B 2 460 GLY 460 482 ?   ?   ?   B . n 
B 2 461 ARG 461 483 ?   ?   ?   B . n 
B 2 462 LEU 462 484 ?   ?   ?   B . n 
B 2 463 LEU 463 485 ?   ?   ?   B . n 
B 2 464 GLU 464 486 ?   ?   ?   B . n 
B 2 465 SER 465 487 ?   ?   ?   B . n 
B 2 466 LYS 466 488 ?   ?   ?   B . n 
B 2 467 CYS 467 489 ?   ?   ?   B . n 
B 2 468 TYR 468 490 ?   ?   ?   B . n 
B 2 469 GLN 469 491 ?   ?   ?   B . n 
B 2 470 ILE 470 492 ?   ?   ?   B . n 
B 2 471 THR 471 493 ?   ?   ?   B . n 
B 2 472 VAL 472 494 ?   ?   ?   B . n 
B 2 473 THR 473 495 ?   ?   ?   B . n 
B 2 474 PRO 474 496 ?   ?   ?   B . n 
B 2 475 VAL 475 497 ?   ?   ?   B . n 
B 2 476 PHE 476 498 ?   ?   ?   B . n 
B 2 477 ALA 477 499 ?   ?   ?   B . n 
B 2 478 THR 478 500 ?   ?   ?   B . n 
B 2 479 GLY 479 501 ?   ?   ?   B . n 
B 2 480 PRO 480 502 ?   ?   ?   B . n 
B 2 481 GLY 481 503 ?   ?   ?   B . n 
B 2 482 GLY 482 504 ?   ?   ?   B . n 
B 2 483 SER 483 505 ?   ?   ?   B . n 
B 2 484 GLU 484 506 ?   ?   ?   B . n 
B 2 485 SER 485 507 ?   ?   ?   B . n 
B 2 486 LEU 486 508 ?   ?   ?   B . n 
B 2 487 LYS 487 509 ?   ?   ?   B . n 
B 2 488 ALA 488 510 ?   ?   ?   B . n 
B 2 489 TYR 489 511 ?   ?   ?   B . n 
B 2 490 LEU 490 512 ?   ?   ?   B . n 
B 2 491 LYS 491 513 ?   ?   ?   B . n 
B 2 492 GLN 492 514 ?   ?   ?   B . n 
B 2 493 ALA 493 515 ?   ?   ?   B . n 
B 2 494 ALA 494 516 ?   ?   ?   B . n 
B 2 495 PRO 495 517 ?   ?   ?   B . n 
B 2 496 ALA 496 518 ?   ?   ?   B . n 
B 2 497 ARG 497 519 ?   ?   ?   B . n 
B 2 498 GLY 498 520 ?   ?   ?   B . n 
B 2 499 PRO 499 521 ?   ?   ?   B . n 
B 2 500 THR 500 522 ?   ?   ?   B . n 
B 2 501 VAL 501 523 ?   ?   ?   B . n 
B 2 502 ARG 502 524 ?   ?   ?   B . n 
B 2 503 THR 503 525 ?   ?   ?   B . n 
B 2 504 LYS 504 526 ?   ?   ?   B . n 
B 2 505 LYS 505 527 ?   ?   ?   B . n 
B 2 506 VAL 506 528 ?   ?   ?   B . n 
B 2 507 GLY 507 529 ?   ?   ?   B . n 
B 2 508 LYS 508 530 ?   ?   ?   B . n 
B 2 509 ASN 509 531 ?   ?   ?   B . n 
B 2 510 GLU 510 532 ?   ?   ?   B . n 
B 2 511 ALA 511 533 ?   ?   ?   B . n 
B 2 512 VAL 512 534 ?   ?   ?   B . n 
B 2 513 LEU 513 535 ?   ?   ?   B . n 
B 2 514 ALA 514 536 ?   ?   ?   B . n 
B 2 515 TRP 515 537 ?   ?   ?   B . n 
B 2 516 ASP 516 538 ?   ?   ?   B . n 
B 2 517 GLN 517 539 ?   ?   ?   B . n 
B 2 518 ILE 518 540 ?   ?   ?   B . n 
B 2 519 PRO 519 541 ?   ?   ?   B . n 
B 2 520 VAL 520 542 ?   ?   ?   B . n 
B 2 521 ASP 521 543 ?   ?   ?   B . n 
B 2 522 ASP 522 544 ?   ?   ?   B . n 
B 2 523 GLN 523 545 ?   ?   ?   B . n 
B 2 524 ASN 524 546 ?   ?   ?   B . n 
B 2 525 GLY 525 547 ?   ?   ?   B . n 
B 2 526 PHE 526 548 ?   ?   ?   B . n 
B 2 527 ILE 527 549 ?   ?   ?   B . n 
B 2 528 ARG 528 550 ?   ?   ?   B . n 
B 2 529 ASN 529 551 ?   ?   ?   B . n 
B 2 530 TYR 530 552 ?   ?   ?   B . n 
B 2 531 SER 531 553 ?   ?   ?   B . n 
B 2 532 ILE 532 554 ?   ?   ?   B . n 
B 2 533 SER 533 555 ?   ?   ?   B . n 
B 2 534 TYR 534 556 ?   ?   ?   B . n 
B 2 535 ARG 535 557 ?   ?   ?   B . n 
B 2 536 THR 536 558 ?   ?   ?   B . n 
B 2 537 SER 537 559 ?   ?   ?   B . n 
B 2 538 VAL 538 560 ?   ?   ?   B . n 
B 2 539 GLY 539 561 ?   ?   ?   B . n 
B 2 540 LYS 540 562 ?   ?   ?   B . n 
B 2 541 GLU 541 563 ?   ?   ?   B . n 
B 2 542 MET 542 564 ?   ?   ?   B . n 
B 2 543 VAL 543 565 ?   ?   ?   B . n 
B 2 544 VAL 544 566 ?   ?   ?   B . n 
B 2 545 HIS 545 567 ?   ?   ?   B . n 
B 2 546 VAL 546 568 ?   ?   ?   B . n 
B 2 547 ASP 547 569 ?   ?   ?   B . n 
B 2 548 SER 548 570 ?   ?   ?   B . n 
B 2 549 SER 549 571 ?   ?   ?   B . n 
B 2 550 HIS 550 572 ?   ?   ?   B . n 
B 2 551 THR 551 573 ?   ?   ?   B . n 
B 2 552 GLU 552 574 ?   ?   ?   B . n 
B 2 553 TYR 553 575 ?   ?   ?   B . n 
B 2 554 THR 554 576 ?   ?   ?   B . n 
B 2 555 LEU 555 577 ?   ?   ?   B . n 
B 2 556 SER 556 578 ?   ?   ?   B . n 
B 2 557 SER 557 579 ?   ?   ?   B . n 
B 2 558 LEU 558 580 ?   ?   ?   B . n 
B 2 559 SER 559 581 ?   ?   ?   B . n 
B 2 560 SER 560 582 ?   ?   ?   B . n 
B 2 561 ASP 561 583 ?   ?   ?   B . n 
B 2 562 THR 562 584 ?   ?   ?   B . n 
B 2 563 LEU 563 585 ?   ?   ?   B . n 
B 2 564 TYR 564 586 ?   ?   ?   B . n 
B 2 565 MET 565 587 ?   ?   ?   B . n 
B 2 566 VAL 566 588 ?   ?   ?   B . n 
B 2 567 ARG 567 589 ?   ?   ?   B . n 
B 2 568 MET 568 590 ?   ?   ?   B . n 
B 2 569 ALA 569 591 ?   ?   ?   B . n 
B 2 570 ALA 570 592 ?   ?   ?   B . n 
B 2 571 TYR 571 593 ?   ?   ?   B . n 
B 2 572 THR 572 594 ?   ?   ?   B . n 
B 2 573 ASP 573 595 ?   ?   ?   B . n 
B 2 574 GLU 574 596 ?   ?   ?   B . n 
B 2 575 GLY 575 597 ?   ?   ?   B . n 
B 2 576 GLY 576 598 ?   ?   ?   B . n 
B 2 577 LYS 577 599 ?   ?   ?   B . n 
B 2 578 ASP 578 600 ?   ?   ?   B . n 
B 2 579 GLY 579 601 ?   ?   ?   B . n 
B 2 580 PRO 580 602 ?   ?   ?   B . n 
B 2 581 GLU 581 603 ?   ?   ?   B . n 
B 2 582 PHE 582 604 ?   ?   ?   B . n 
B 2 583 THR 583 605 ?   ?   ?   B . n 
B 2 584 PHE 584 606 ?   ?   ?   B . n 
B 2 585 THR 585 607 ?   ?   ?   B . n 
B 2 586 THR 586 608 ?   ?   ?   B . n 
B 2 587 PRO 587 609 ?   ?   ?   B . n 
B 2 588 LYS 588 610 ?   ?   ?   B . n 
B 2 589 PHE 589 611 ?   ?   ?   B . n 
B 2 590 ALA 590 612 ?   ?   ?   B . n 
B 2 591 GLN 591 613 ?   ?   ?   B . n 
B 2 592 GLY 592 614 ?   ?   ?   B . n 
B 2 593 GLU 593 615 ?   ?   ?   B . n 
B 2 594 ILE 594 616 ?   ?   ?   B . n 
B 2 595 GLU 595 617 ?   ?   ?   B . n 
B 2 596 GLU 596 618 ?   ?   ?   B . n 
B 2 597 GLN 597 619 ?   ?   ?   B . n 
B 2 598 LYS 598 620 ?   ?   ?   B . n 
B 2 599 LEU 599 621 ?   ?   ?   B . n 
B 2 600 ILE 600 622 ?   ?   ?   B . n 
B 2 601 SER 601 623 ?   ?   ?   B . n 
B 2 602 GLU 602 624 ?   ?   ?   B . n 
B 2 603 GLU 603 625 ?   ?   ?   B . n 
B 2 604 ASP 604 626 ?   ?   ?   B . n 
B 2 605 LEU 605 627 ?   ?   ?   B . n 
B 2 606 GLY 606 628 ?   ?   ?   B . n 
B 2 607 GLY 607 629 ?   ?   ?   B . n 
B 2 608 GLU 608 630 ?   ?   ?   B . n 
B 2 609 GLN 609 631 ?   ?   ?   B . n 
B 2 610 LYS 610 632 ?   ?   ?   B . n 
B 2 611 LEU 611 633 ?   ?   ?   B . n 
B 2 612 ILE 612 634 ?   ?   ?   B . n 
B 2 613 SER 613 635 ?   ?   ?   B . n 
B 2 614 GLU 614 636 ?   ?   ?   B . n 
B 2 615 GLU 615 637 ?   ?   ?   B . n 
B 2 616 ASP 616 638 ?   ?   ?   B . n 
B 2 617 LEU 617 639 ?   ?   ?   B . n 
B 2 618 HIS 618 640 ?   ?   ?   B . n 
B 2 619 HIS 619 641 ?   ?   ?   B . n 
B 2 620 HIS 620 642 ?   ?   ?   B . n 
B 2 621 HIS 621 643 ?   ?   ?   B . n 
B 2 622 HIS 622 644 ?   ?   ?   B . n 
B 2 623 HIS 623 645 ?   ?   ?   B . n 
C 3 1   GLU 1   24  ?   ?   ?   C . n 
C 3 2   VAL 2   25  ?   ?   ?   C . n 
C 3 3   LEU 3   26  ?   ?   ?   C . n 
C 3 4   GLU 4   27  ?   ?   ?   C . n 
C 3 5   GLU 5   28  ?   ?   ?   C . n 
C 3 6   PRO 6   29  ?   ?   ?   C . n 
C 3 7   LEU 7   30  ?   ?   ?   C . n 
C 3 8   PRO 8   31  ?   ?   ?   C . n 
C 3 9   LEU 9   32  ?   ?   ?   C . n 
C 3 10  THR 10  33  ?   ?   ?   C . n 
C 3 11  PRO 11  34  ?   ?   ?   C . n 
C 3 12  GLU 12  35  ?   ?   ?   C . n 
C 3 13  ILE 13  36  ?   ?   ?   C . n 
C 3 14  HIS 14  37  ?   ?   ?   C . n 
C 3 15  LYS 15  38  ?   ?   ?   C . n 
C 3 16  VAL 16  39  ?   ?   ?   C . n 
C 3 17  SER 17  40  ?   ?   ?   C . n 
C 3 18  PHE 18  41  ?   ?   ?   C . n 
C 3 19  GLN 19  42  ?   ?   ?   C . n 
C 3 20  LEU 20  43  ?   ?   ?   C . n 
C 3 21  LYS 21  44  ?   ?   ?   C . n 
C 3 22  LEU 22  45  ?   ?   ?   C . n 
C 3 23  GLN 23  46  ?   ?   ?   C . n 
C 3 24  GLU 24  47  ?   ?   ?   C . n 
C 3 25  VAL 25  48  ?   ?   ?   C . n 
C 3 26  ASN 26  49  ?   ?   ?   C . n 
C 3 27  LEU 27  50  ?   ?   ?   C . n 
C 3 28  GLU 28  51  ?   ?   ?   C . n 
C 3 29  TRP 29  52  ?   ?   ?   C . n 
C 3 30  THR 30  53  ?   ?   ?   C . n 
C 3 31  VAL 31  54  ?   ?   ?   C . n 
C 3 32  PRO 32  55  ?   ?   ?   C . n 
C 3 33  ALA 33  56  ?   ?   ?   C . n 
C 3 34  LEU 34  57  ?   ?   ?   C . n 
C 3 35  THR 35  58  ?   ?   ?   C . n 
C 3 36  HIS 36  59  ?   ?   ?   C . n 
C 3 37  GLU 37  60  ?   ?   ?   C . n 
C 3 38  GLU 38  61  ?   ?   ?   C . n 
C 3 39  LEU 39  62  ?   ?   ?   C . n 
C 3 40  ASN 40  63  ?   ?   ?   C . n 
C 3 41  MET 41  64  ?   ?   ?   C . n 
C 3 42  ILE 42  65  ?   ?   ?   C . n 
C 3 43  PHE 43  66  ?   ?   ?   C . n 
C 3 44  GLN 44  67  ?   ?   ?   C . n 
C 3 45  ILE 45  68  ?   ?   ?   C . n 
C 3 46  GLU 46  69  ?   ?   ?   C . n 
C 3 47  ILE 47  70  ?   ?   ?   C . n 
C 3 48  SER 48  71  ?   ?   ?   C . n 
C 3 49  ARG 49  72  ?   ?   ?   C . n 
C 3 50  LEU 50  73  ?   ?   ?   C . n 
C 3 51  ASN 51  74  ?   ?   ?   C . n 
C 3 52  ILE 52  75  ?   ?   ?   C . n 
C 3 53  SER 53  76  ?   ?   ?   C . n 
C 3 54  ASN 54  77  ?   ?   ?   C . n 
C 3 55  THR 55  78  ?   ?   ?   C . n 
C 3 56  ILE 56  79  ?   ?   ?   C . n 
C 3 57  TRP 57  80  ?   ?   ?   C . n 
C 3 58  VAL 58  81  ?   ?   ?   C . n 
C 3 59  GLU 59  82  ?   ?   ?   C . n 
C 3 60  ASN 60  83  ?   ?   ?   C . n 
C 3 61  TYR 61  84  ?   ?   ?   C . n 
C 3 62  SER 62  85  ?   ?   ?   C . n 
C 3 63  THR 63  86  ?   ?   ?   C . n 
C 3 64  THR 64  87  ?   ?   ?   C . n 
C 3 65  VAL 65  88  ?   ?   ?   C . n 
C 3 66  LYS 66  89  ?   ?   ?   C . n 
C 3 67  ARG 67  90  ?   ?   ?   C . n 
C 3 68  GLU 68  91  ?   ?   ?   C . n 
C 3 69  GLU 69  92  ?   ?   ?   C . n 
C 3 70  ALA 70  93  ?   ?   ?   C . n 
C 3 71  VAL 71  94  ?   ?   ?   C . n 
C 3 72  ARG 72  95  ?   ?   ?   C . n 
C 3 73  TRP 73  96  ?   ?   ?   C . n 
C 3 74  ASN 74  97  ?   ?   ?   C . n 
C 3 75  TRP 75  98  ?   ?   ?   C . n 
C 3 76  THR 76  99  ?   ?   ?   C . n 
C 3 77  SER 77  100 ?   ?   ?   C . n 
C 3 78  ASP 78  101 ?   ?   ?   C . n 
C 3 79  ILE 79  102 ?   ?   ?   C . n 
C 3 80  PRO 80  103 ?   ?   ?   C . n 
C 3 81  LEU 81  104 ?   ?   ?   C . n 
C 3 82  GLU 82  105 ?   ?   ?   C . n 
C 3 83  CYS 83  106 ?   ?   ?   C . n 
C 3 84  VAL 84  107 ?   ?   ?   C . n 
C 3 85  LYS 85  108 ?   ?   ?   C . n 
C 3 86  HIS 86  109 ?   ?   ?   C . n 
C 3 87  PHE 87  110 ?   ?   ?   C . n 
C 3 88  ILE 88  111 ?   ?   ?   C . n 
C 3 89  ARG 89  112 ?   ?   ?   C . n 
C 3 90  ILE 90  113 ?   ?   ?   C . n 
C 3 91  ARG 91  114 ?   ?   ?   C . n 
C 3 92  ALA 92  115 ?   ?   ?   C . n 
C 3 93  LEU 93  116 ?   ?   ?   C . n 
C 3 94  VAL 94  117 ?   ?   ?   C . n 
C 3 95  ASP 95  118 ?   ?   ?   C . n 
C 3 96  ASP 96  119 ?   ?   ?   C . n 
C 3 97  THR 97  120 ?   ?   ?   C . n 
C 3 98  LYS 98  121 ?   ?   ?   C . n 
C 3 99  SER 99  122 ?   ?   ?   C . n 
C 3 100 LEU 100 123 ?   ?   ?   C . n 
C 3 101 PRO 101 124 ?   ?   ?   C . n 
C 3 102 GLN 102 125 ?   ?   ?   C . n 
C 3 103 SER 103 126 ?   ?   ?   C . n 
C 3 104 SER 104 127 ?   ?   ?   C . n 
C 3 105 TRP 105 128 ?   ?   ?   C . n 
C 3 106 GLY 106 129 ?   ?   ?   C . n 
C 3 107 ASN 107 130 ?   ?   ?   C . n 
C 3 108 TRP 108 131 ?   ?   ?   C . n 
C 3 109 SER 109 132 ?   ?   ?   C . n 
C 3 110 SER 110 133 ?   ?   ?   C . n 
C 3 111 TRP 111 134 ?   ?   ?   C . n 
C 3 112 LYS 112 135 ?   ?   ?   C . n 
C 3 113 GLU 113 136 ?   ?   ?   C . n 
C 3 114 VAL 114 137 ?   ?   ?   C . n 
C 3 115 ASN 115 138 ?   ?   ?   C . n 
C 3 116 ALA 116 139 ?   ?   ?   C . n 
C 3 117 LYS 117 140 ?   ?   ?   C . n 
C 3 118 VAL 118 141 ?   ?   ?   C . n 
C 3 119 SER 119 142 ?   ?   ?   C . n 
C 3 120 VAL 120 143 ?   ?   ?   C . n 
C 3 121 GLU 121 144 144 GLU GLU C . n 
C 3 122 PRO 122 145 145 PRO PRO C . n 
C 3 123 ASP 123 146 146 ASP ASP C . n 
C 3 124 LYS 124 147 147 LYS LYS C . n 
C 3 125 SER 125 148 148 SER SER C . n 
C 3 126 LEU 126 149 149 LEU LEU C . n 
C 3 127 ILE 127 150 150 ILE ILE C . n 
C 3 128 PHE 128 151 151 PHE PHE C . n 
C 3 129 PRO 129 152 152 PRO PRO C . n 
C 3 130 LYS 130 153 153 LYS LYS C . n 
C 3 131 ASP 131 154 154 ASP ASP C . n 
C 3 132 LYS 132 155 155 LYS LYS C . n 
C 3 133 VAL 133 156 156 VAL VAL C . n 
C 3 134 LEU 134 157 157 LEU LEU C . n 
C 3 135 GLU 135 158 158 GLU GLU C . n 
C 3 136 GLU 136 159 159 GLU GLU C . n 
C 3 137 GLY 137 160 160 GLY GLY C . n 
C 3 138 SER 138 161 161 SER SER C . n 
C 3 139 ASN 139 162 162 ASN ASN C . n 
C 3 140 VAL 140 163 163 VAL VAL C . n 
C 3 141 THR 141 164 164 THR THR C . n 
C 3 142 ILE 142 165 165 ILE ILE C . n 
C 3 143 CYS 143 166 166 CYS CYS C . n 
C 3 144 LEU 144 167 167 LEU LEU C . n 
C 3 145 MET 145 168 168 MET MET C . n 
C 3 146 TYR 146 169 169 TYR TYR C . n 
C 3 147 GLY 147 170 170 GLY GLY C . n 
C 3 148 GLN 148 171 171 GLN GLN C . n 
C 3 149 ASN 149 172 172 ASN ASN C . n 
C 3 150 VAL 150 173 173 VAL VAL C . n 
C 3 151 TYR 151 174 174 TYR TYR C . n 
C 3 152 ASN 152 175 175 ASN ASN C . n 
C 3 153 VAL 153 176 176 VAL VAL C . n 
C 3 154 SER 154 177 177 SER SER C . n 
C 3 155 CYS 155 178 178 CYS CYS C . n 
C 3 156 LYS 156 179 179 LYS LYS C . n 
C 3 157 LEU 157 180 180 LEU LEU C . n 
C 3 158 GLN 158 181 181 GLN GLN C . n 
C 3 159 ASP 159 182 182 ASP ASP C . n 
C 3 160 GLU 160 183 183 GLU GLU C . n 
C 3 161 PRO 161 184 184 PRO PRO C . n 
C 3 162 ILE 162 185 185 ILE ILE C . n 
C 3 163 HIS 163 186 186 HIS HIS C . n 
C 3 164 GLY 164 187 187 GLY GLY C . n 
C 3 165 GLU 165 188 188 GLU GLU C . n 
C 3 166 GLN 166 189 189 GLN GLN C . n 
C 3 167 LEU 167 190 190 LEU LEU C . n 
C 3 168 ASP 168 191 191 ASP ASP C . n 
C 3 169 SER 169 192 192 SER SER C . n 
C 3 170 HIS 170 193 193 HIS HIS C . n 
C 3 171 VAL 171 194 194 VAL VAL C . n 
C 3 172 SER 172 195 195 SER SER C . n 
C 3 173 LEU 173 196 196 LEU LEU C . n 
C 3 174 LEU 174 197 197 LEU LEU C . n 
C 3 175 LYS 175 198 198 LYS LYS C . n 
C 3 176 LEU 176 199 199 LEU LEU C . n 
C 3 177 ASN 177 200 200 ASN ASN C . n 
C 3 178 ASN 178 201 201 ASN ASN C . n 
C 3 179 VAL 179 202 202 VAL VAL C . n 
C 3 180 VAL 180 203 203 VAL VAL C . n 
C 3 181 PHE 181 204 204 PHE PHE C . n 
C 3 182 LEU 182 205 205 LEU LEU C . n 
C 3 183 SER 183 206 206 SER SER C . n 
C 3 184 ASP 184 207 207 ASP ASP C . n 
C 3 185 THR 185 208 208 THR THR C . n 
C 3 186 GLY 186 209 209 GLY GLY C . n 
C 3 187 THR 187 210 210 THR THR C . n 
C 3 188 ASN 188 211 211 ASN ASN C . n 
C 3 189 ILE 189 212 212 ILE ILE C . n 
C 3 190 ASN 190 213 213 ASN ASN C . n 
C 3 191 CYS 191 214 214 CYS CYS C . n 
C 3 192 GLN 192 215 215 GLN GLN C . n 
C 3 193 ALA 193 216 216 ALA ALA C . n 
C 3 194 THR 194 217 217 THR THR C . n 
C 3 195 LYS 195 218 218 LYS LYS C . n 
C 3 196 GLY 196 219 219 GLY GLY C . n 
C 3 197 PRO 197 220 220 PRO PRO C . n 
C 3 198 LYS 198 221 221 LYS LYS C . n 
C 3 199 ARG 199 222 222 ARG ARG C . n 
C 3 200 ILE 200 223 223 ILE ILE C . n 
C 3 201 PHE 201 224 224 PHE PHE C . n 
C 3 202 GLY 202 225 225 GLY GLY C . n 
C 3 203 THR 203 226 226 THR THR C . n 
C 3 204 VAL 204 227 227 VAL VAL C . n 
C 3 205 LEU 205 228 228 LEU LEU C . n 
C 3 206 PHE 206 229 229 PHE PHE C . n 
C 3 207 VAL 207 230 230 VAL VAL C . n 
C 3 208 SER 208 231 231 SER SER C . n 
C 3 209 LYS 209 232 232 LYS LYS C . n 
C 3 210 VAL 210 233 233 VAL VAL C . n 
C 3 211 LEU 211 234 234 LEU LEU C . n 
C 3 212 GLU 212 235 235 GLU GLU C . n 
C 3 213 GLU 213 236 236 GLU GLU C . n 
C 3 214 PRO 214 237 237 PRO PRO C . n 
C 3 215 LYS 215 238 238 LYS LYS C . n 
C 3 216 ASN 216 239 239 ASN ASN C . n 
C 3 217 VAL 217 240 240 VAL VAL C . n 
C 3 218 SER 218 241 241 SER SER C . n 
C 3 219 CYS 219 242 242 CYS CYS C . n 
C 3 220 GLU 220 243 243 GLU GLU C . n 
C 3 221 THR 221 244 244 THR THR C . n 
C 3 222 ARG 222 245 245 ARG ARG C . n 
C 3 223 ASP 223 246 246 ASP ASP C . n 
C 3 224 PHE 224 247 247 PHE PHE C . n 
C 3 225 LYS 225 248 248 LYS LYS C . n 
C 3 226 THR 226 249 249 THR THR C . n 
C 3 227 LEU 227 250 250 LEU LEU C . n 
C 3 228 ASP 228 251 251 ASP ASP C . n 
C 3 229 CYS 229 252 252 CYS CYS C . n 
C 3 230 SER 230 253 253 SER SER C . n 
C 3 231 TRP 231 254 254 TRP TRP C . n 
C 3 232 GLU 232 255 255 GLU GLU C . n 
C 3 233 PRO 233 256 256 PRO PRO C . n 
C 3 234 GLY 234 257 257 GLY GLY C . n 
C 3 235 VAL 235 258 258 VAL VAL C . n 
C 3 236 ASP 236 259 259 ASP ASP C . n 
C 3 237 THR 237 260 260 THR THR C . n 
C 3 238 THR 238 261 261 THR THR C . n 
C 3 239 LEU 239 262 262 LEU LEU C . n 
C 3 240 THR 240 263 263 THR THR C . n 
C 3 241 TRP 241 264 264 TRP TRP C . n 
C 3 242 ARG 242 265 265 ARG ARG C . n 
C 3 243 LYS 243 266 266 LYS LYS C . n 
C 3 244 GLN 244 267 267 GLN GLN C . n 
C 3 245 ARG 245 268 268 ARG ARG C . n 
C 3 246 PHE 246 269 269 PHE PHE C . n 
C 3 247 GLN 247 270 270 GLN GLN C . n 
C 3 248 ASN 248 271 271 ASN ASN C . n 
C 3 249 TYR 249 272 272 TYR TYR C . n 
C 3 250 THR 250 273 273 THR THR C . n 
C 3 251 LEU 251 274 274 LEU LEU C . n 
C 3 252 CYS 252 275 275 CYS CYS C . n 
C 3 253 GLU 253 276 276 GLU GLU C . n 
C 3 254 SER 254 277 277 SER SER C . n 
C 3 255 PHE 255 278 278 PHE PHE C . n 
C 3 256 SER 256 279 279 SER SER C . n 
C 3 257 LYS 257 280 280 LYS LYS C . n 
C 3 258 ARG 258 281 281 ARG ARG C . n 
C 3 259 CYS 259 282 282 CYS CYS C . n 
C 3 260 GLU 260 283 283 GLU GLU C . n 
C 3 261 VAL 261 284 284 VAL VAL C . n 
C 3 262 SER 262 285 285 SER SER C . n 
C 3 263 ASN 263 286 286 ASN ASN C . n 
C 3 264 TYR 264 287 287 TYR TYR C . n 
C 3 265 ARG 265 288 288 ARG ARG C . n 
C 3 266 ASN 266 289 289 ASN ASN C . n 
C 3 267 SER 267 290 290 SER SER C . n 
C 3 268 TYR 268 291 291 TYR TYR C . n 
C 3 269 THR 269 292 292 THR THR C . n 
C 3 270 TRP 270 293 293 TRP TRP C . n 
C 3 271 GLN 271 294 294 GLN GLN C . n 
C 3 272 ILE 272 295 295 ILE ILE C . n 
C 3 273 THR 273 296 296 THR THR C . n 
C 3 274 GLU 274 297 297 GLU GLU C . n 
C 3 275 GLY 275 298 298 GLY GLY C . n 
C 3 276 SER 276 299 299 SER SER C . n 
C 3 277 GLN 277 300 300 GLN GLN C . n 
C 3 278 GLU 278 301 301 GLU GLU C . n 
C 3 279 MET 279 302 302 MET MET C . n 
C 3 280 TYR 280 303 303 TYR TYR C . n 
C 3 281 ASN 281 304 304 ASN ASN C . n 
C 3 282 PHE 282 305 305 PHE PHE C . n 
C 3 283 THR 283 306 306 THR THR C . n 
C 3 284 LEU 284 307 307 LEU LEU C . n 
C 3 285 THR 285 308 308 THR THR C . n 
C 3 286 ALA 286 309 309 ALA ALA C . n 
C 3 287 GLU 287 310 310 GLU GLU C . n 
C 3 288 ASN 288 311 311 ASN ASN C . n 
C 3 289 GLN 289 312 312 GLN GLN C . n 
C 3 290 LEU 290 313 313 LEU LEU C . n 
C 3 291 ARG 291 314 314 ARG ARG C . n 
C 3 292 LYS 292 315 315 LYS LYS C . n 
C 3 293 ARG 293 316 316 ARG ARG C . n 
C 3 294 SER 294 317 317 SER SER C . n 
C 3 295 VAL 295 318 318 VAL VAL C . n 
C 3 296 ASN 296 319 319 ASN ASN C . n 
C 3 297 ILE 297 320 320 ILE ILE C . n 
C 3 298 ASN 298 321 321 ASN ASN C . n 
C 3 299 PHE 299 322 322 PHE PHE C . n 
C 3 300 ASN 300 323 323 ASN ASN C . n 
C 3 301 LEU 301 324 324 LEU LEU C . n 
C 3 302 THR 302 325 325 THR THR C . n 
C 3 303 HIS 303 326 326 HIS HIS C . n 
C 3 304 ARG 304 327 327 ARG ARG C . n 
C 3 305 VAL 305 328 ?   ?   ?   C . n 
C 3 306 HIS 306 329 ?   ?   ?   C . n 
C 3 307 PRO 307 330 ?   ?   ?   C . n 
C 3 308 LYS 308 331 ?   ?   ?   C . n 
C 3 309 ALA 309 332 ?   ?   ?   C . n 
C 3 310 PRO 310 333 ?   ?   ?   C . n 
C 3 311 GLN 311 334 ?   ?   ?   C . n 
C 3 312 ASP 312 335 ?   ?   ?   C . n 
C 3 313 VAL 313 336 ?   ?   ?   C . n 
C 3 314 THR 314 337 ?   ?   ?   C . n 
C 3 315 LEU 315 338 ?   ?   ?   C . n 
C 3 316 LYS 316 339 ?   ?   ?   C . n 
C 3 317 ILE 317 340 ?   ?   ?   C . n 
C 3 318 ILE 318 341 ?   ?   ?   C . n 
C 3 319 GLY 319 342 ?   ?   ?   C . n 
C 3 320 ALA 320 343 ?   ?   ?   C . n 
C 3 321 THR 321 344 ?   ?   ?   C . n 
C 3 322 LYS 322 345 ?   ?   ?   C . n 
C 3 323 ALA 323 346 ?   ?   ?   C . n 
C 3 324 ASN 324 347 ?   ?   ?   C . n 
C 3 325 MET 325 348 ?   ?   ?   C . n 
C 3 326 THR 326 349 ?   ?   ?   C . n 
C 3 327 TRP 327 350 ?   ?   ?   C . n 
C 3 328 LYS 328 351 ?   ?   ?   C . n 
C 3 329 VAL 329 352 ?   ?   ?   C . n 
C 3 330 HIS 330 353 ?   ?   ?   C . n 
C 3 331 SER 331 354 ?   ?   ?   C . n 
C 3 332 HIS 332 355 ?   ?   ?   C . n 
C 3 333 GLY 333 356 ?   ?   ?   C . n 
C 3 334 ASN 334 357 ?   ?   ?   C . n 
C 3 335 ASN 335 358 ?   ?   ?   C . n 
C 3 336 TYR 336 359 ?   ?   ?   C . n 
C 3 337 THR 337 360 ?   ?   ?   C . n 
C 3 338 LEU 338 361 ?   ?   ?   C . n 
C 3 339 LEU 339 362 ?   ?   ?   C . n 
C 3 340 CYS 340 363 ?   ?   ?   C . n 
C 3 341 GLN 341 364 ?   ?   ?   C . n 
C 3 342 VAL 342 365 ?   ?   ?   C . n 
C 3 343 LYS 343 366 ?   ?   ?   C . n 
C 3 344 LEU 344 367 ?   ?   ?   C . n 
C 3 345 GLN 345 368 ?   ?   ?   C . n 
C 3 346 TYR 346 369 ?   ?   ?   C . n 
C 3 347 GLY 347 370 ?   ?   ?   C . n 
C 3 348 GLU 348 371 ?   ?   ?   C . n 
C 3 349 VAL 349 372 ?   ?   ?   C . n 
C 3 350 ILE 350 373 ?   ?   ?   C . n 
C 3 351 HIS 351 374 ?   ?   ?   C . n 
C 3 352 GLU 352 375 ?   ?   ?   C . n 
C 3 353 HIS 353 376 ?   ?   ?   C . n 
C 3 354 ASN 354 377 ?   ?   ?   C . n 
C 3 355 VAL 355 378 ?   ?   ?   C . n 
C 3 356 SER 356 379 ?   ?   ?   C . n 
C 3 357 VAL 357 380 ?   ?   ?   C . n 
C 3 358 HIS 358 381 ?   ?   ?   C . n 
C 3 359 MET 359 382 ?   ?   ?   C . n 
C 3 360 SER 360 383 ?   ?   ?   C . n 
C 3 361 ALA 361 384 ?   ?   ?   C . n 
C 3 362 ASN 362 385 ?   ?   ?   C . n 
C 3 363 TYR 363 386 ?   ?   ?   C . n 
C 3 364 LEU 364 387 ?   ?   ?   C . n 
C 3 365 PHE 365 388 ?   ?   ?   C . n 
C 3 366 SER 366 389 ?   ?   ?   C . n 
C 3 367 ASP 367 390 ?   ?   ?   C . n 
C 3 368 LEU 368 391 ?   ?   ?   C . n 
C 3 369 ASP 369 392 ?   ?   ?   C . n 
C 3 370 PRO 370 393 ?   ?   ?   C . n 
C 3 371 ASP 371 394 ?   ?   ?   C . n 
C 3 372 THR 372 395 ?   ?   ?   C . n 
C 3 373 LYS 373 396 ?   ?   ?   C . n 
C 3 374 TYR 374 397 ?   ?   ?   C . n 
C 3 375 LYS 375 398 ?   ?   ?   C . n 
C 3 376 ALA 376 399 ?   ?   ?   C . n 
C 3 377 PHE 377 400 ?   ?   ?   C . n 
C 3 378 VAL 378 401 ?   ?   ?   C . n 
C 3 379 ARG 379 402 ?   ?   ?   C . n 
C 3 380 CYS 380 403 ?   ?   ?   C . n 
C 3 381 ALA 381 404 ?   ?   ?   C . n 
C 3 382 SER 382 405 ?   ?   ?   C . n 
C 3 383 ALA 383 406 ?   ?   ?   C . n 
C 3 384 ASN 384 407 ?   ?   ?   C . n 
C 3 385 HIS 385 408 ?   ?   ?   C . n 
C 3 386 PHE 386 409 ?   ?   ?   C . n 
C 3 387 TRP 387 410 ?   ?   ?   C . n 
C 3 388 LYS 388 411 ?   ?   ?   C . n 
C 3 389 TRP 389 412 ?   ?   ?   C . n 
C 3 390 SER 390 413 ?   ?   ?   C . n 
C 3 391 ASP 391 414 ?   ?   ?   C . n 
C 3 392 TRP 392 415 ?   ?   ?   C . n 
C 3 393 THR 393 416 ?   ?   ?   C . n 
C 3 394 GLN 394 417 ?   ?   ?   C . n 
C 3 395 LYS 395 418 ?   ?   ?   C . n 
C 3 396 GLU 396 419 ?   ?   ?   C . n 
C 3 397 PHE 397 420 ?   ?   ?   C . n 
C 3 398 SER 398 421 ?   ?   ?   C . n 
C 3 399 THR 399 422 ?   ?   ?   C . n 
C 3 400 PRO 400 423 ?   ?   ?   C . n 
C 3 401 GLU 401 424 ?   ?   ?   C . n 
C 3 402 THR 402 425 ?   ?   ?   C . n 
C 3 403 ALA 403 426 ?   ?   ?   C . n 
C 3 404 PRO 404 427 ?   ?   ?   C . n 
C 3 405 SER 405 428 ?   ?   ?   C . n 
C 3 406 GLN 406 429 ?   ?   ?   C . n 
C 3 407 ALA 407 430 ?   ?   ?   C . n 
C 3 408 LEU 408 431 ?   ?   ?   C . n 
C 3 409 ASP 409 432 ?   ?   ?   C . n 
C 3 410 VAL 410 433 ?   ?   ?   C . n 
C 3 411 TRP 411 434 ?   ?   ?   C . n 
C 3 412 ARG 412 435 ?   ?   ?   C . n 
C 3 413 GLN 413 436 ?   ?   ?   C . n 
C 3 414 VAL 414 437 ?   ?   ?   C . n 
C 3 415 TRP 415 438 ?   ?   ?   C . n 
C 3 416 SER 416 439 ?   ?   ?   C . n 
C 3 417 GLU 417 440 ?   ?   ?   C . n 
C 3 418 ASN 418 441 ?   ?   ?   C . n 
C 3 419 GLY 419 442 ?   ?   ?   C . n 
C 3 420 ARG 420 443 ?   ?   ?   C . n 
C 3 421 ARG 421 444 ?   ?   ?   C . n 
C 3 422 ILE 422 445 ?   ?   ?   C . n 
C 3 423 VAL 423 446 ?   ?   ?   C . n 
C 3 424 THR 424 447 ?   ?   ?   C . n 
C 3 425 LEU 425 448 ?   ?   ?   C . n 
C 3 426 PHE 426 449 ?   ?   ?   C . n 
C 3 427 TRP 427 450 ?   ?   ?   C . n 
C 3 428 LYS 428 451 ?   ?   ?   C . n 
C 3 429 PRO 429 452 ?   ?   ?   C . n 
C 3 430 LEU 430 453 ?   ?   ?   C . n 
C 3 431 LEU 431 454 ?   ?   ?   C . n 
C 3 432 LYS 432 455 ?   ?   ?   C . n 
C 3 433 SER 433 456 ?   ?   ?   C . n 
C 3 434 GLN 434 457 ?   ?   ?   C . n 
C 3 435 ALA 435 458 ?   ?   ?   C . n 
C 3 436 ASN 436 459 ?   ?   ?   C . n 
C 3 437 GLY 437 460 ?   ?   ?   C . n 
C 3 438 LYS 438 461 ?   ?   ?   C . n 
C 3 439 ILE 439 462 ?   ?   ?   C . n 
C 3 440 ILE 440 463 ?   ?   ?   C . n 
C 3 441 SER 441 464 ?   ?   ?   C . n 
C 3 442 TYR 442 465 ?   ?   ?   C . n 
C 3 443 ASN 443 466 ?   ?   ?   C . n 
C 3 444 ILE 444 467 ?   ?   ?   C . n 
C 3 445 VAL 445 468 ?   ?   ?   C . n 
C 3 446 VAL 446 469 ?   ?   ?   C . n 
C 3 447 GLU 447 470 ?   ?   ?   C . n 
C 3 448 ASN 448 471 ?   ?   ?   C . n 
C 3 449 GLU 449 472 ?   ?   ?   C . n 
C 3 450 ALA 450 473 ?   ?   ?   C . n 
C 3 451 LYS 451 474 ?   ?   ?   C . n 
C 3 452 PRO 452 475 ?   ?   ?   C . n 
C 3 453 THR 453 476 ?   ?   ?   C . n 
C 3 454 GLU 454 477 ?   ?   ?   C . n 
C 3 455 SER 455 478 ?   ?   ?   C . n 
C 3 456 GLU 456 479 ?   ?   ?   C . n 
C 3 457 HIS 457 480 ?   ?   ?   C . n 
C 3 458 TYR 458 481 ?   ?   ?   C . n 
C 3 459 CYS 459 482 ?   ?   ?   C . n 
C 3 460 VAL 460 483 ?   ?   ?   C . n 
C 3 461 TRP 461 484 ?   ?   ?   C . n 
C 3 462 ALA 462 485 ?   ?   ?   C . n 
C 3 463 PRO 463 486 ?   ?   ?   C . n 
C 3 464 ALA 464 487 ?   ?   ?   C . n 
C 3 465 LEU 465 488 ?   ?   ?   C . n 
C 3 466 SER 466 489 ?   ?   ?   C . n 
C 3 467 THR 467 490 ?   ?   ?   C . n 
C 3 468 ASN 468 491 ?   ?   ?   C . n 
C 3 469 LEU 469 492 ?   ?   ?   C . n 
C 3 470 SER 470 493 ?   ?   ?   C . n 
C 3 471 LEU 471 494 ?   ?   ?   C . n 
C 3 472 ASP 472 495 ?   ?   ?   C . n 
C 3 473 LEU 473 496 ?   ?   ?   C . n 
C 3 474 GLN 474 497 ?   ?   ?   C . n 
C 3 475 PRO 475 498 ?   ?   ?   C . n 
C 3 476 TYR 476 499 ?   ?   ?   C . n 
C 3 477 LYS 477 500 ?   ?   ?   C . n 
C 3 478 ILE 478 501 ?   ?   ?   C . n 
C 3 479 ARG 479 502 ?   ?   ?   C . n 
C 3 480 ILE 480 503 ?   ?   ?   C . n 
C 3 481 THR 481 504 ?   ?   ?   C . n 
C 3 482 THR 482 505 ?   ?   ?   C . n 
C 3 483 ASN 483 506 ?   ?   ?   C . n 
C 3 484 ASN 484 507 ?   ?   ?   C . n 
C 3 485 SER 485 508 ?   ?   ?   C . n 
C 3 486 MET 486 509 ?   ?   ?   C . n 
C 3 487 GLY 487 510 ?   ?   ?   C . n 
C 3 488 ALA 488 511 ?   ?   ?   C . n 
C 3 489 SER 489 512 ?   ?   ?   C . n 
C 3 490 PRO 490 513 ?   ?   ?   C . n 
C 3 491 GLU 491 514 ?   ?   ?   C . n 
C 3 492 SER 492 515 ?   ?   ?   C . n 
C 3 493 LEU 493 516 ?   ?   ?   C . n 
C 3 494 MET 494 517 ?   ?   ?   C . n 
C 3 495 VAL 495 518 ?   ?   ?   C . n 
C 3 496 LEU 496 519 ?   ?   ?   C . n 
C 3 497 SER 497 520 ?   ?   ?   C . n 
C 3 498 ASN 498 521 ?   ?   ?   C . n 
C 3 499 ASP 499 522 ?   ?   ?   C . n 
C 3 500 SER 500 523 ?   ?   ?   C . n 
C 3 501 GLY 501 524 ?   ?   ?   C . n 
C 3 502 HIS 502 525 ?   ?   ?   C . n 
C 3 503 GLU 503 526 ?   ?   ?   C . n 
C 3 504 GLU 504 527 ?   ?   ?   C . n 
C 3 505 VAL 505 528 ?   ?   ?   C . n 
C 3 506 LYS 506 529 ?   ?   ?   C . n 
C 3 507 GLU 507 530 ?   ?   ?   C . n 
C 3 508 LYS 508 531 ?   ?   ?   C . n 
C 3 509 THR 509 532 ?   ?   ?   C . n 
C 3 510 ILE 510 533 ?   ?   ?   C . n 
C 3 511 LYS 511 534 ?   ?   ?   C . n 
C 3 512 GLY 512 535 ?   ?   ?   C . n 
C 3 513 ILE 513 536 ?   ?   ?   C . n 
C 3 514 LYS 514 537 ?   ?   ?   C . n 
C 3 515 ASP 515 538 ?   ?   ?   C . n 
C 3 516 ALA 516 539 ?   ?   ?   C . n 
C 3 517 PHE 517 540 ?   ?   ?   C . n 
C 3 518 ASN 518 541 ?   ?   ?   C . n 
C 3 519 ILE 519 542 ?   ?   ?   C . n 
C 3 520 SER 520 543 ?   ?   ?   C . n 
C 3 521 TRP 521 544 ?   ?   ?   C . n 
C 3 522 GLU 522 545 ?   ?   ?   C . n 
C 3 523 PRO 523 546 ?   ?   ?   C . n 
C 3 524 VAL 524 547 ?   ?   ?   C . n 
C 3 525 SER 525 548 ?   ?   ?   C . n 
C 3 526 GLY 526 549 ?   ?   ?   C . n 
C 3 527 ASP 527 550 ?   ?   ?   C . n 
C 3 528 THR 528 551 ?   ?   ?   C . n 
C 3 529 MET 529 552 ?   ?   ?   C . n 
C 3 530 GLY 530 553 ?   ?   ?   C . n 
C 3 531 TYR 531 554 ?   ?   ?   C . n 
C 3 532 VAL 532 555 ?   ?   ?   C . n 
C 3 533 VAL 533 556 ?   ?   ?   C . n 
C 3 534 ASP 534 557 ?   ?   ?   C . n 
C 3 535 TRP 535 558 ?   ?   ?   C . n 
C 3 536 CYS 536 559 ?   ?   ?   C . n 
C 3 537 ALA 537 560 ?   ?   ?   C . n 
C 3 538 HIS 538 561 ?   ?   ?   C . n 
C 3 539 SER 539 562 ?   ?   ?   C . n 
C 3 540 GLN 540 563 ?   ?   ?   C . n 
C 3 541 ASP 541 564 ?   ?   ?   C . n 
C 3 542 GLN 542 565 ?   ?   ?   C . n 
C 3 543 ARG 543 566 ?   ?   ?   C . n 
C 3 544 CYS 544 567 ?   ?   ?   C . n 
C 3 545 ASP 545 568 ?   ?   ?   C . n 
C 3 546 LEU 546 569 ?   ?   ?   C . n 
C 3 547 GLN 547 570 ?   ?   ?   C . n 
C 3 548 TRP 548 571 ?   ?   ?   C . n 
C 3 549 LYS 549 572 ?   ?   ?   C . n 
C 3 550 ASN 550 573 ?   ?   ?   C . n 
C 3 551 LEU 551 574 ?   ?   ?   C . n 
C 3 552 GLY 552 575 ?   ?   ?   C . n 
C 3 553 PRO 553 576 ?   ?   ?   C . n 
C 3 554 ASN 554 577 ?   ?   ?   C . n 
C 3 555 THR 555 578 ?   ?   ?   C . n 
C 3 556 THR 556 579 ?   ?   ?   C . n 
C 3 557 SER 557 580 ?   ?   ?   C . n 
C 3 558 THR 558 581 ?   ?   ?   C . n 
C 3 559 THR 559 582 ?   ?   ?   C . n 
C 3 560 ILE 560 583 ?   ?   ?   C . n 
C 3 561 THR 561 584 ?   ?   ?   C . n 
C 3 562 SER 562 585 ?   ?   ?   C . n 
C 3 563 ASP 563 586 ?   ?   ?   C . n 
C 3 564 ASP 564 587 ?   ?   ?   C . n 
C 3 565 PHE 565 588 ?   ?   ?   C . n 
C 3 566 LYS 566 589 ?   ?   ?   C . n 
C 3 567 PRO 567 590 ?   ?   ?   C . n 
C 3 568 GLY 568 591 ?   ?   ?   C . n 
C 3 569 VAL 569 592 ?   ?   ?   C . n 
C 3 570 ARG 570 593 ?   ?   ?   C . n 
C 3 571 TYR 571 594 ?   ?   ?   C . n 
C 3 572 ASN 572 595 ?   ?   ?   C . n 
C 3 573 PHE 573 596 ?   ?   ?   C . n 
C 3 574 ARG 574 597 ?   ?   ?   C . n 
C 3 575 ILE 575 598 ?   ?   ?   C . n 
C 3 576 PHE 576 599 ?   ?   ?   C . n 
C 3 577 GLU 577 600 ?   ?   ?   C . n 
C 3 578 ARG 578 601 ?   ?   ?   C . n 
C 3 579 SER 579 602 ?   ?   ?   C . n 
C 3 580 VAL 580 603 ?   ?   ?   C . n 
C 3 581 GLU 581 604 ?   ?   ?   C . n 
C 3 582 HIS 582 605 ?   ?   ?   C . n 
C 3 583 LYS 583 606 ?   ?   ?   C . n 
C 3 584 ALA 584 607 ?   ?   ?   C . n 
C 3 585 ARG 585 608 ?   ?   ?   C . n 
C 3 586 LEU 586 609 ?   ?   ?   C . n 
C 3 587 VAL 587 610 ?   ?   ?   C . n 
C 3 588 GLU 588 611 ?   ?   ?   C . n 
C 3 589 LYS 589 612 ?   ?   ?   C . n 
C 3 590 GLN 590 613 ?   ?   ?   C . n 
C 3 591 ARG 591 614 ?   ?   ?   C . n 
C 3 592 GLY 592 615 ?   ?   ?   C . n 
C 3 593 TYR 593 616 ?   ?   ?   C . n 
C 3 594 THR 594 617 ?   ?   ?   C . n 
C 3 595 GLN 595 618 ?   ?   ?   C . n 
C 3 596 GLU 596 619 ?   ?   ?   C . n 
C 3 597 LEU 597 620 ?   ?   ?   C . n 
C 3 598 ALA 598 621 ?   ?   ?   C . n 
C 3 599 PRO 599 622 ?   ?   ?   C . n 
C 3 600 LEU 600 623 ?   ?   ?   C . n 
C 3 601 VAL 601 624 ?   ?   ?   C . n 
C 3 602 ASN 602 625 ?   ?   ?   C . n 
C 3 603 PRO 603 626 ?   ?   ?   C . n 
C 3 604 LYS 604 627 ?   ?   ?   C . n 
C 3 605 VAL 605 628 ?   ?   ?   C . n 
C 3 606 GLU 606 629 ?   ?   ?   C . n 
C 3 607 ILE 607 630 ?   ?   ?   C . n 
C 3 608 PRO 608 631 ?   ?   ?   C . n 
C 3 609 TYR 609 632 ?   ?   ?   C . n 
C 3 610 SER 610 633 ?   ?   ?   C . n 
C 3 611 THR 611 634 ?   ?   ?   C . n 
C 3 612 PRO 612 635 ?   ?   ?   C . n 
C 3 613 ASN 613 636 ?   ?   ?   C . n 
C 3 614 SER 614 637 ?   ?   ?   C . n 
C 3 615 PHE 615 638 ?   ?   ?   C . n 
C 3 616 VAL 616 639 ?   ?   ?   C . n 
C 3 617 LEU 617 640 ?   ?   ?   C . n 
C 3 618 ARG 618 641 ?   ?   ?   C . n 
C 3 619 TRP 619 642 ?   ?   ?   C . n 
C 3 620 PRO 620 643 ?   ?   ?   C . n 
C 3 621 ASP 621 644 ?   ?   ?   C . n 
C 3 622 TYR 622 645 ?   ?   ?   C . n 
C 3 623 ASP 623 646 ?   ?   ?   C . n 
C 3 624 SER 624 647 ?   ?   ?   C . n 
C 3 625 ASP 625 648 ?   ?   ?   C . n 
C 3 626 PHE 626 649 ?   ?   ?   C . n 
C 3 627 GLN 627 650 ?   ?   ?   C . n 
C 3 628 ALA 628 651 ?   ?   ?   C . n 
C 3 629 GLY 629 652 ?   ?   ?   C . n 
C 3 630 PHE 630 653 ?   ?   ?   C . n 
C 3 631 ILE 631 654 ?   ?   ?   C . n 
C 3 632 LYS 632 655 ?   ?   ?   C . n 
C 3 633 GLY 633 656 ?   ?   ?   C . n 
C 3 634 TYR 634 657 ?   ?   ?   C . n 
C 3 635 LEU 635 658 ?   ?   ?   C . n 
C 3 636 VAL 636 659 ?   ?   ?   C . n 
C 3 637 TYR 637 660 ?   ?   ?   C . n 
C 3 638 VAL 638 661 ?   ?   ?   C . n 
C 3 639 LYS 639 662 ?   ?   ?   C . n 
C 3 640 SER 640 663 ?   ?   ?   C . n 
C 3 641 LYS 641 664 ?   ?   ?   C . n 
C 3 642 GLU 642 665 ?   ?   ?   C . n 
C 3 643 MET 643 666 ?   ?   ?   C . n 
C 3 644 GLN 644 667 ?   ?   ?   C . n 
C 3 645 CYS 645 668 ?   ?   ?   C . n 
C 3 646 ASN 646 669 ?   ?   ?   C . n 
C 3 647 GLN 647 670 ?   ?   ?   C . n 
C 3 648 PRO 648 671 ?   ?   ?   C . n 
C 3 649 TRP 649 672 ?   ?   ?   C . n 
C 3 650 GLU 650 673 ?   ?   ?   C . n 
C 3 651 ARG 651 674 ?   ?   ?   C . n 
C 3 652 THR 652 675 ?   ?   ?   C . n 
C 3 653 LEU 653 676 ?   ?   ?   C . n 
C 3 654 LEU 654 677 ?   ?   ?   C . n 
C 3 655 PRO 655 678 ?   ?   ?   C . n 
C 3 656 ASP 656 679 ?   ?   ?   C . n 
C 3 657 ASN 657 680 ?   ?   ?   C . n 
C 3 658 SER 658 681 ?   ?   ?   C . n 
C 3 659 VAL 659 682 ?   ?   ?   C . n 
C 3 660 LEU 660 683 ?   ?   ?   C . n 
C 3 661 CYS 661 684 ?   ?   ?   C . n 
C 3 662 LYS 662 685 ?   ?   ?   C . n 
C 3 663 TYR 663 686 ?   ?   ?   C . n 
C 3 664 ASP 664 687 ?   ?   ?   C . n 
C 3 665 ILE 665 688 ?   ?   ?   C . n 
C 3 666 ASN 666 689 ?   ?   ?   C . n 
C 3 667 GLY 667 690 ?   ?   ?   C . n 
C 3 668 SER 668 691 ?   ?   ?   C . n 
C 3 669 GLU 669 692 ?   ?   ?   C . n 
C 3 670 THR 670 693 ?   ?   ?   C . n 
C 3 671 LYS 671 694 ?   ?   ?   C . n 
C 3 672 THR 672 695 ?   ?   ?   C . n 
C 3 673 LEU 673 696 ?   ?   ?   C . n 
C 3 674 THR 674 697 ?   ?   ?   C . n 
C 3 675 VAL 675 698 ?   ?   ?   C . n 
C 3 676 GLU 676 699 ?   ?   ?   C . n 
C 3 677 ASN 677 700 ?   ?   ?   C . n 
C 3 678 LEU 678 701 ?   ?   ?   C . n 
C 3 679 GLN 679 702 ?   ?   ?   C . n 
C 3 680 PRO 680 703 ?   ?   ?   C . n 
C 3 681 GLU 681 704 ?   ?   ?   C . n 
C 3 682 SER 682 705 ?   ?   ?   C . n 
C 3 683 LEU 683 706 ?   ?   ?   C . n 
C 3 684 TYR 684 707 ?   ?   ?   C . n 
C 3 685 GLU 685 708 ?   ?   ?   C . n 
C 3 686 PHE 686 709 ?   ?   ?   C . n 
C 3 687 PHE 687 710 ?   ?   ?   C . n 
C 3 688 VAL 688 711 ?   ?   ?   C . n 
C 3 689 THR 689 712 ?   ?   ?   C . n 
C 3 690 PRO 690 713 ?   ?   ?   C . n 
C 3 691 TYR 691 714 ?   ?   ?   C . n 
C 3 692 THR 692 715 ?   ?   ?   C . n 
C 3 693 SER 693 716 ?   ?   ?   C . n 
C 3 694 ALA 694 717 ?   ?   ?   C . n 
C 3 695 GLY 695 718 ?   ?   ?   C . n 
C 3 696 PRO 696 719 ?   ?   ?   C . n 
C 3 697 GLY 697 720 ?   ?   ?   C . n 
C 3 698 PRO 698 721 ?   ?   ?   C . n 
C 3 699 ASN 699 722 ?   ?   ?   C . n 
C 3 700 GLU 700 723 ?   ?   ?   C . n 
C 3 701 THR 701 724 ?   ?   ?   C . n 
C 3 702 PHE 702 725 ?   ?   ?   C . n 
C 3 703 THR 703 726 ?   ?   ?   C . n 
C 3 704 LYS 704 727 ?   ?   ?   C . n 
C 3 705 VAL 705 728 ?   ?   ?   C . n 
C 3 706 THR 706 729 ?   ?   ?   C . n 
C 3 707 THR 707 730 ?   ?   ?   C . n 
C 3 708 PRO 708 731 ?   ?   ?   C . n 
C 3 709 ASP 709 732 ?   ?   ?   C . n 
C 3 710 ALA 710 733 ?   ?   ?   C . n 
C 3 711 ARG 711 734 ?   ?   ?   C . n 
C 3 712 SER 712 735 ?   ?   ?   C . n 
C 3 713 HIS 713 736 ?   ?   ?   C . n 
C 3 714 MET 714 737 ?   ?   ?   C . n 
C 3 715 LEU 715 738 ?   ?   ?   C . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
D 4 NAG 1 D NAG 1 B NAG 1022 n 
D 4 NAG 2 D NAG 2 B NAG 1023 n 
E 4 NAG 1 E NAG 1 C NAG 1013 n 
E 4 NAG 2 E NAG 2 C NAG 1014 n 
F 4 NAG 1 F NAG 1 C NAG 1016 n 
F 4 NAG 2 F NAG 2 C NAG 1017 n 
G 4 NAG 1 G NAG 1 C NAG 1018 n 
G 4 NAG 2 G NAG 2 C NAG 1019 n 
H 4 NAG 1 H NAG 1 C NAG 1020 n 
H 4 NAG 2 H NAG 2 C NAG 1021 n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
I 5 NAG 1 701 1003 NAG NAG B . 
J 5 NAG 1 702 1006 NAG NAG B . 
K 5 NAG 1 801 1015 NAG NAG C . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8V2C 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8V2C 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8V2C 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8V2C 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002  ? 4700 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.401  ? 6379 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 25.237 ? 672  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.040  ? 746  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.003  ? 802  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8V2C 
_struct.title                        'Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8V2C 
_struct_keywords.text            'cytokine signaling, OSM, gp130, OSMR, CYTOKINE, CYTOKINE-RECEPTOR complex' 
_struct_keywords.pdbx_keywords   CYTOKINE/RECEPTOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
K N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ONCM_MOUSE  P53347 ? 1 
;ANRGCSNSSSQLLSQLQNQANLTGNTESLLEPYIRLQNLNTPDLRAACTQHSVAFPSEDTLRQLSKPHFLSTVYTTLDRV
LYQLDALRQKFLKTPAFPKLDSARHNILGIRNNVFCMARLLNHSLEIPEPTQTDSGASRSTTTPDVFNTKIGSCGFLWGY
HRFMGSVGRVFREWDDGSTRSRR
;
24 
2 UNP IL6RB_MOUSE Q00560 ? 2 
;QLLEPCGYIYPEFPVVQRGSNFTAICVLKEACLQHYYVNASYIVWKTNHAAVPREQVTVINRTTSSVTFTDVVLPSVQLT
CNILSFGQIEQNVYGVTMLSGFPPDKPTNLTCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCQSKHGTSCMV
SYMPTYYVNIEVWVEAENALGKVSSESINFDPVDKVKPTPPYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTK
DASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYEDRPSRPPSFWYKTNPSHGQEY
RSVRLIWKALPLSEANGKILDYEVILTQSKSVSQTYTVTGTELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVTAA
YSVVNLKAFPKDNLLWVEWTPPPKPVSKYILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGP
GGSESLKAYLKQAAPARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVVHVDSSHTEYTLSSLSS
DTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIE
;
23 
3 UNP OSMR_MOUSE  O70458 ? 3 
;EVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDIP
LECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDE
PIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLT
WRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQDVTLKIIGA
TKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTP
ETAPSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRI
TTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTI
TSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKS
KEMQCNQPWERTLLPDNSVLCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHML
;
24 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8V2C A 1 ? 183 ? P53347 24 ? 206 ? 24 206 
2 2 8V2C B 1 ? 595 ? Q00560 23 ? 617 ? 23 617 
3 3 8V2C C 1 ? 715 ? O70458 24 ? 738 ? 24 738 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8V2C GLU B 596 ? UNP Q00560 ? ? 'expression tag' 618 1  
2 8V2C GLN B 597 ? UNP Q00560 ? ? 'expression tag' 619 2  
2 8V2C LYS B 598 ? UNP Q00560 ? ? 'expression tag' 620 3  
2 8V2C LEU B 599 ? UNP Q00560 ? ? 'expression tag' 621 4  
2 8V2C ILE B 600 ? UNP Q00560 ? ? 'expression tag' 622 5  
2 8V2C SER B 601 ? UNP Q00560 ? ? 'expression tag' 623 6  
2 8V2C GLU B 602 ? UNP Q00560 ? ? 'expression tag' 624 7  
2 8V2C GLU B 603 ? UNP Q00560 ? ? 'expression tag' 625 8  
2 8V2C ASP B 604 ? UNP Q00560 ? ? 'expression tag' 626 9  
2 8V2C LEU B 605 ? UNP Q00560 ? ? 'expression tag' 627 10 
2 8V2C GLY B 606 ? UNP Q00560 ? ? 'expression tag' 628 11 
2 8V2C GLY B 607 ? UNP Q00560 ? ? 'expression tag' 629 12 
2 8V2C GLU B 608 ? UNP Q00560 ? ? 'expression tag' 630 13 
2 8V2C GLN B 609 ? UNP Q00560 ? ? 'expression tag' 631 14 
2 8V2C LYS B 610 ? UNP Q00560 ? ? 'expression tag' 632 15 
2 8V2C LEU B 611 ? UNP Q00560 ? ? 'expression tag' 633 16 
2 8V2C ILE B 612 ? UNP Q00560 ? ? 'expression tag' 634 17 
2 8V2C SER B 613 ? UNP Q00560 ? ? 'expression tag' 635 18 
2 8V2C GLU B 614 ? UNP Q00560 ? ? 'expression tag' 636 19 
2 8V2C GLU B 615 ? UNP Q00560 ? ? 'expression tag' 637 20 
2 8V2C ASP B 616 ? UNP Q00560 ? ? 'expression tag' 638 21 
2 8V2C LEU B 617 ? UNP Q00560 ? ? 'expression tag' 639 22 
2 8V2C HIS B 618 ? UNP Q00560 ? ? 'expression tag' 640 23 
2 8V2C HIS B 619 ? UNP Q00560 ? ? 'expression tag' 641 24 
2 8V2C HIS B 620 ? UNP Q00560 ? ? 'expression tag' 642 25 
2 8V2C HIS B 621 ? UNP Q00560 ? ? 'expression tag' 643 26 
2 8V2C HIS B 622 ? UNP Q00560 ? ? 'expression tag' 644 27 
2 8V2C HIS B 623 ? UNP Q00560 ? ? 'expression tag' 645 28 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? GLY A 24  ? SER A 32  GLY A 47  1 ? 16 
HELX_P HELX_P2  AA2 LEU A 29  ? GLN A 37  ? LEU A 52  GLN A 60  1 ? 9  
HELX_P HELX_P3  AA3 THR A 41  ? HIS A 51  ? THR A 64  HIS A 74  1 ? 11 
HELX_P HELX_P4  AA4 SER A 57  ? LEU A 64  ? SER A 80  LEU A 87  1 ? 8  
HELX_P HELX_P5  AA5 SER A 65  ? LEU A 92  ? SER A 88  LEU A 115 1 ? 28 
HELX_P HELX_P6  AA6 PHE A 97  ? LEU A 121 ? PHE A 120 LEU A 144 1 ? 25 
HELX_P HELX_P7  AA7 VAL A 146 ? SER A 178 ? VAL A 169 SER A 201 1 ? 33 
HELX_P HELX_P8  AA8 ASP B 191 ? ASP B 194 ? ASP B 213 ASP B 216 5 ? 4  
HELX_P HELX_P9  AA9 SER B 223 ? LEU B 228 ? SER B 245 LEU B 250 1 ? 6  
HELX_P HELX_P10 AB1 PRO B 249 ? MET B 254 ? PRO B 271 MET B 276 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 5   SG  ? ? ? 1_555 A CYS 116 SG ? ? A CYS 28  A CYS 139 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf2  disulf ?    ? A CYS 48  SG  ? ? ? 1_555 A CYS 154 SG ? ? A CYS 71  A CYS 177 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf3  disulf ?    ? B CYS 112 SG  ? ? ? 1_555 B CYS 122 SG ? ? B CYS 134 B CYS 144 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf4  disulf ?    ? B CYS 150 SG  ? ? ? 1_555 B CYS 158 SG ? ? B CYS 172 B CYS 180 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf5  disulf ?    ? C CYS 155 SG  ? ? ? 1_555 C CYS 191 SG ? ? C CYS 178 C CYS 214 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf6  disulf ?    ? C CYS 219 SG  ? ? ? 1_555 C CYS 229 SG ? ? C CYS 242 C CYS 252 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf7  disulf ?    ? C CYS 252 SG  ? ? ? 1_555 C CYS 259 SG ? ? C CYS 275 C CYS 282 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
covale1  covale one  ? B ASN 109 ND2 ? ? ? 1_555 D NAG .   C1 ? ? B ASN 131 D NAG 1   1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation 
covale2  covale one  ? B ASN 135 ND2 ? ? ? 1_555 J NAG .   C1 ? ? B ASN 157 B NAG 702 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale3  covale one  ? B ASN 203 ND2 ? ? ? 1_555 I NAG .   C1 ? ? B ASN 225 B NAG 701 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale4  covale one  ? C ASN 139 ND2 ? ? ? 1_555 E NAG .   C1 ? ? C ASN 162 E NAG 1   1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale5  covale one  ? C ASN 216 ND2 ? ? ? 1_555 K NAG .   C1 ? ? C ASN 239 C NAG 801 1_555 ? ? ? ? ? ? ? 1.451 ? N-Glycosylation 
covale6  covale one  ? C ASN 248 ND2 ? ? ? 1_555 F NAG .   C1 ? ? C ASN 271 F NAG 1   1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
covale7  covale one  ? C ASN 281 ND2 ? ? ? 1_555 G NAG .   C1 ? ? C ASN 304 G NAG 1   1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale8  covale one  ? C ASN 300 ND2 ? ? ? 1_555 H NAG .   C1 ? ? C ASN 323 H NAG 1   1_555 ? ? ? ? ? ? ? 1.438 ? N-Glycosylation 
covale9  covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? D NAG 1   D NAG 2   1_555 ? ? ? ? ? ? ? 1.445 ? ?               
covale10 covale both ? E NAG .   O4  ? ? ? 1_555 E NAG .   C1 ? ? E NAG 1   E NAG 2   1_555 ? ? ? ? ? ? ? 1.441 ? ?               
covale11 covale both ? F NAG .   O4  ? ? ? 1_555 F NAG .   C1 ? ? F NAG 1   F NAG 2   1_555 ? ? ? ? ? ? ? 1.442 ? ?               
covale12 covale both ? G NAG .   O4  ? ? ? 1_555 G NAG .   C1 ? ? G NAG 1   G NAG 2   1_555 ? ? ? ? ? ? ? 1.442 ? ?               
covale13 covale both ? H NAG .   O4  ? ? ? 1_555 H NAG .   C1 ? ? H NAG 1   H NAG 2   1_555 ? ? ? ? ? ? ? 1.439 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG D .   ? ASN B 109 ? NAG D 1   ? 1_555 ASN B 131 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG E .   ? ASN C 139 ? NAG E 1   ? 1_555 ASN C 162 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG F .   ? ASN C 248 ? NAG F 1   ? 1_555 ASN C 271 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG G .   ? ASN C 281 ? NAG G 1   ? 1_555 ASN C 304 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG H .   ? ASN C 300 ? NAG H 1   ? 1_555 ASN C 323 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  NAG I .   ? ASN B 203 ? NAG B 701 ? 1_555 ASN B 225 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
7  NAG J .   ? ASN B 135 ? NAG B 702 ? 1_555 ASN B 157 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
8  NAG K .   ? ASN C 216 ? NAG C 801 ? 1_555 ASN C 239 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
9  CYS A 5   ? CYS A 116 ? CYS A 28  ? 1_555 CYS A 139 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS A 48  ? CYS A 154 ? CYS A 71  ? 1_555 CYS A 177 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS B 112 ? CYS B 122 ? CYS B 134 ? 1_555 CYS B 144 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS B 150 ? CYS B 158 ? CYS B 172 ? 1_555 CYS B 180 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
13 CYS C 155 ? CYS C 191 ? CYS C 178 ? 1_555 CYS C 214 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
14 CYS C 219 ? CYS C 229 ? CYS C 242 ? 1_555 CYS C 252 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
15 CYS C 252 ? CYS C 259 ? CYS C 275 ? 1_555 CYS C 282 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PHE 
_struct_mon_prot_cis.label_seq_id           128 
_struct_mon_prot_cis.label_asym_id          C 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PHE 
_struct_mon_prot_cis.auth_seq_id            151 
_struct_mon_prot_cis.auth_asym_id           C 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    129 
_struct_mon_prot_cis.pdbx_label_asym_id_2   C 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     152 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    C 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -1.63 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 3 ? 
AA5 ? 4 ? 
AA6 ? 3 ? 
AA7 ? 4 ? 
AA8 ? 3 ? 
AA9 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS B 158 ? MET B 159 ? CYS B 180 MET B 181 
AA1 2 MET B 120 ? ASP B 125 ? MET B 142 ASP B 147 
AA1 3 THR B 108 ? ASN B 115 ? THR B 130 ASN B 137 
AA1 4 VAL B 196 ? LYS B 197 ? VAL B 218 LYS B 219 
AA2 1 CYS B 150 ? GLN B 151 ? CYS B 172 GLN B 173 
AA2 2 ASN B 135 ? GLU B 141 ? ASN B 157 GLU B 163 
AA2 3 ILE B 170 ? GLU B 177 ? ILE B 192 GLU B 199 
AA2 4 LYS B 182 ? SER B 184 ? LYS B 204 SER B 206 
AA3 1 CYS B 150 ? GLN B 151 ? CYS B 172 GLN B 173 
AA3 2 ASN B 135 ? GLU B 141 ? ASN B 157 GLU B 163 
AA3 3 ILE B 170 ? GLU B 177 ? ILE B 192 GLU B 199 
AA3 4 ILE B 188 ? PHE B 190 ? ILE B 210 PHE B 212 
AA4 1 TYR B 202 ? THR B 207 ? TYR B 224 THR B 229 
AA4 2 LEU B 216 ? VAL B 221 ? LEU B 238 VAL B 243 
AA4 3 SER B 259 ? VAL B 262 ? SER B 281 VAL B 284 
AA5 1 ILE B 246 ? GLN B 247 ? ILE B 268 GLN B 269 
AA5 2 LEU B 231 ? ARG B 238 ? LEU B 253 ARG B 260 
AA5 3 GLU B 270 ? LYS B 279 ? GLU B 292 LYS B 301 
AA5 4 ALA B 293 ? THR B 296 ? ALA B 315 THR B 318 
AA6 1 SER C 125 ? PHE C 128 ? SER C 148 PHE C 151 
AA6 2 VAL C 140 ? TYR C 146 ? VAL C 163 TYR C 169 
AA6 3 VAL C 171 ? LEU C 176 ? VAL C 194 LEU C 199 
AA7 1 LYS C 132 ? GLU C 135 ? LYS C 155 GLU C 158 
AA7 2 ILE C 200 ? SER C 208 ? ILE C 223 SER C 231 
AA7 3 THR C 187 ? ALA C 193 ? THR C 210 ALA C 216 
AA7 4 VAL C 153 ? CYS C 155 ? VAL C 176 CYS C 178 
AA8 1 LYS C 215 ? SER C 218 ? LYS C 238 SER C 241 
AA8 2 THR C 226 ? GLU C 232 ? THR C 249 GLU C 255 
AA8 3 SER C 267 ? GLN C 271 ? SER C 290 GLN C 294 
AA9 1 ASN C 248 ? LEU C 251 ? ASN C 271 LEU C 274 
AA9 2 TYR C 280 ? GLU C 287 ? TYR C 303 GLU C 310 
AA9 3 LYS C 292 ? PHE C 299 ? LYS C 315 PHE C 322 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O CYS B 158 ? O CYS B 180 N CYS B 122 ? N CYS B 144 
AA1 2 3 O LEU B 121 ? O LEU B 143 N ILE B 113 ? N ILE B 135 
AA1 3 4 N VAL B 114 ? N VAL B 136 O LYS B 197 ? O LYS B 219 
AA2 1 2 O CYS B 150 ? O CYS B 172 N LEU B 138 ? N LEU B 160 
AA2 2 3 N LYS B 139 ? N LYS B 161 O TRP B 173 ? O TRP B 195 
AA2 3 4 N ALA B 176 ? N ALA B 198 O VAL B 183 ? O VAL B 205 
AA3 1 2 O CYS B 150 ? O CYS B 172 N LEU B 138 ? N LEU B 160 
AA3 2 3 N LYS B 139 ? N LYS B 161 O TRP B 173 ? O TRP B 195 
AA3 3 4 N ILE B 170 ? N ILE B 192 O PHE B 190 ? O PHE B 212 
AA4 1 2 N SER B 205 ? N SER B 227 O SER B 219 ? O SER B 241 
AA4 2 3 N LEU B 218 ? N LEU B 240 O PHE B 260 ? O PHE B 282 
AA5 1 2 O ILE B 246 ? O ILE B 268 N TYR B 237 ? N TYR B 259 
AA5 2 3 N LYS B 232 ? N LYS B 254 O ILE B 278 ? O ILE B 300 
AA5 3 4 N TYR B 271 ? N TYR B 293 O GLY B 295 ? O GLY B 317 
AA6 1 2 N LEU C 126 ? N LEU C 149 O MET C 145 ? O MET C 168 
AA6 2 3 N ILE C 142 ? N ILE C 165 O LEU C 174 ? O LEU C 197 
AA7 1 2 N LEU C 134 ? N LEU C 157 O PHE C 206 ? O PHE C 229 
AA7 2 3 O LEU C 205 ? O LEU C 228 N THR C 187 ? N THR C 210 
AA7 3 4 O GLN C 192 ? O GLN C 215 N SER C 154 ? N SER C 177 
AA8 1 2 N SER C 218 ? N SER C 241 O SER C 230 ? O SER C 253 
AA8 2 3 N LEU C 227 ? N LEU C 250 O TRP C 270 ? O TRP C 293 
AA9 1 2 N THR C 250 ? N THR C 273 O THR C 285 ? O THR C 308 
AA9 2 3 N ALA C 286 ? N ALA C 309 O ARG C 293 ? O ARG C 316 
# 
_pdbx_entry_details.entry_id                   8V2C 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 26  ? ? -96.61  30.37   
2 1 PHE A 120 ? ? -160.03 77.87   
3 1 TRP C 264 ? ? -79.77  -166.89 
4 1 MET C 302 ? ? -174.04 147.86  
5 1 ASN C 311 ? ? -126.70 -169.05 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8V2C 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8V2C 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.46 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               270829 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Mouse OSM in complex with gp130 and OSMR' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_imaging.entry_id                        8V2C 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1400 
_em_imaging.nominal_defocus_max             2600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8V2C 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8V2C 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLU 152 ? A GLU 129 
2   1 Y 1 A PRO 153 ? A PRO 130 
3   1 Y 1 A THR 154 ? A THR 131 
4   1 Y 1 A GLN 155 ? A GLN 132 
5   1 Y 1 A THR 156 ? A THR 133 
6   1 Y 1 A ASP 157 ? A ASP 134 
7   1 Y 1 A SER 158 ? A SER 135 
8   1 Y 1 A GLY 159 ? A GLY 136 
9   1 Y 1 A ALA 160 ? A ALA 137 
10  1 Y 1 A SER 161 ? A SER 138 
11  1 Y 1 A ARG 203 ? A ARG 180 
12  1 Y 1 A SER 204 ? A SER 181 
13  1 Y 1 A ARG 205 ? A ARG 182 
14  1 Y 1 A ARG 206 ? A ARG 183 
15  1 Y 1 B GLN 23  ? B GLN 1   
16  1 Y 1 B LEU 24  ? B LEU 2   
17  1 Y 1 B LEU 25  ? B LEU 3   
18  1 Y 1 B GLU 26  ? B GLU 4   
19  1 Y 1 B PRO 27  ? B PRO 5   
20  1 Y 1 B CYS 28  ? B CYS 6   
21  1 Y 1 B GLY 29  ? B GLY 7   
22  1 Y 1 B TYR 30  ? B TYR 8   
23  1 Y 1 B ILE 31  ? B ILE 9   
24  1 Y 1 B TYR 32  ? B TYR 10  
25  1 Y 1 B PRO 33  ? B PRO 11  
26  1 Y 1 B GLU 34  ? B GLU 12  
27  1 Y 1 B PHE 35  ? B PHE 13  
28  1 Y 1 B PRO 36  ? B PRO 14  
29  1 Y 1 B VAL 37  ? B VAL 15  
30  1 Y 1 B VAL 38  ? B VAL 16  
31  1 Y 1 B GLN 39  ? B GLN 17  
32  1 Y 1 B ARG 40  ? B ARG 18  
33  1 Y 1 B GLY 41  ? B GLY 19  
34  1 Y 1 B SER 42  ? B SER 20  
35  1 Y 1 B ASN 43  ? B ASN 21  
36  1 Y 1 B PHE 44  ? B PHE 22  
37  1 Y 1 B THR 45  ? B THR 23  
38  1 Y 1 B ALA 46  ? B ALA 24  
39  1 Y 1 B ILE 47  ? B ILE 25  
40  1 Y 1 B CYS 48  ? B CYS 26  
41  1 Y 1 B VAL 49  ? B VAL 27  
42  1 Y 1 B LEU 50  ? B LEU 28  
43  1 Y 1 B LYS 51  ? B LYS 29  
44  1 Y 1 B GLU 52  ? B GLU 30  
45  1 Y 1 B ALA 53  ? B ALA 31  
46  1 Y 1 B CYS 54  ? B CYS 32  
47  1 Y 1 B LEU 55  ? B LEU 33  
48  1 Y 1 B GLN 56  ? B GLN 34  
49  1 Y 1 B HIS 57  ? B HIS 35  
50  1 Y 1 B TYR 58  ? B TYR 36  
51  1 Y 1 B TYR 59  ? B TYR 37  
52  1 Y 1 B VAL 60  ? B VAL 38  
53  1 Y 1 B ASN 61  ? B ASN 39  
54  1 Y 1 B ALA 62  ? B ALA 40  
55  1 Y 1 B SER 63  ? B SER 41  
56  1 Y 1 B TYR 64  ? B TYR 42  
57  1 Y 1 B ILE 65  ? B ILE 43  
58  1 Y 1 B VAL 66  ? B VAL 44  
59  1 Y 1 B TRP 67  ? B TRP 45  
60  1 Y 1 B LYS 68  ? B LYS 46  
61  1 Y 1 B THR 69  ? B THR 47  
62  1 Y 1 B ASN 70  ? B ASN 48  
63  1 Y 1 B HIS 71  ? B HIS 49  
64  1 Y 1 B ALA 72  ? B ALA 50  
65  1 Y 1 B ALA 73  ? B ALA 51  
66  1 Y 1 B VAL 74  ? B VAL 52  
67  1 Y 1 B PRO 75  ? B PRO 53  
68  1 Y 1 B ARG 76  ? B ARG 54  
69  1 Y 1 B GLU 77  ? B GLU 55  
70  1 Y 1 B GLN 78  ? B GLN 56  
71  1 Y 1 B VAL 79  ? B VAL 57  
72  1 Y 1 B THR 80  ? B THR 58  
73  1 Y 1 B VAL 81  ? B VAL 59  
74  1 Y 1 B ILE 82  ? B ILE 60  
75  1 Y 1 B ASN 83  ? B ASN 61  
76  1 Y 1 B ARG 84  ? B ARG 62  
77  1 Y 1 B THR 85  ? B THR 63  
78  1 Y 1 B THR 86  ? B THR 64  
79  1 Y 1 B SER 87  ? B SER 65  
80  1 Y 1 B SER 88  ? B SER 66  
81  1 Y 1 B VAL 89  ? B VAL 67  
82  1 Y 1 B THR 90  ? B THR 68  
83  1 Y 1 B PHE 91  ? B PHE 69  
84  1 Y 1 B THR 92  ? B THR 70  
85  1 Y 1 B ASP 93  ? B ASP 71  
86  1 Y 1 B VAL 94  ? B VAL 72  
87  1 Y 1 B VAL 95  ? B VAL 73  
88  1 Y 1 B LEU 96  ? B LEU 74  
89  1 Y 1 B PRO 97  ? B PRO 75  
90  1 Y 1 B SER 98  ? B SER 76  
91  1 Y 1 B VAL 99  ? B VAL 77  
92  1 Y 1 B GLN 100 ? B GLN 78  
93  1 Y 1 B LEU 101 ? B LEU 79  
94  1 Y 1 B THR 102 ? B THR 80  
95  1 Y 1 B CYS 103 ? B CYS 81  
96  1 Y 1 B ASN 104 ? B ASN 82  
97  1 Y 1 B ILE 105 ? B ILE 83  
98  1 Y 1 B LEU 106 ? B LEU 84  
99  1 Y 1 B SER 107 ? B SER 85  
100 1 Y 1 B PHE 108 ? B PHE 86  
101 1 Y 1 B GLY 109 ? B GLY 87  
102 1 Y 1 B GLN 110 ? B GLN 88  
103 1 Y 1 B ILE 111 ? B ILE 89  
104 1 Y 1 B GLU 112 ? B GLU 90  
105 1 Y 1 B GLN 113 ? B GLN 91  
106 1 Y 1 B ASN 114 ? B ASN 92  
107 1 Y 1 B VAL 115 ? B VAL 93  
108 1 Y 1 B TYR 116 ? B TYR 94  
109 1 Y 1 B GLY 117 ? B GLY 95  
110 1 Y 1 B VAL 118 ? B VAL 96  
111 1 Y 1 B THR 119 ? B THR 97  
112 1 Y 1 B MET 120 ? B MET 98  
113 1 Y 1 B LEU 121 ? B LEU 99  
114 1 Y 1 B SER 122 ? B SER 100 
115 1 Y 1 B GLY 123 ? B GLY 101 
116 1 Y 1 B ASP 322 ? B ASP 300 
117 1 Y 1 B ARG 323 ? B ARG 301 
118 1 Y 1 B PRO 324 ? B PRO 302 
119 1 Y 1 B SER 325 ? B SER 303 
120 1 Y 1 B ARG 326 ? B ARG 304 
121 1 Y 1 B PRO 327 ? B PRO 305 
122 1 Y 1 B PRO 328 ? B PRO 306 
123 1 Y 1 B SER 329 ? B SER 307 
124 1 Y 1 B PHE 330 ? B PHE 308 
125 1 Y 1 B TRP 331 ? B TRP 309 
126 1 Y 1 B TYR 332 ? B TYR 310 
127 1 Y 1 B LYS 333 ? B LYS 311 
128 1 Y 1 B THR 334 ? B THR 312 
129 1 Y 1 B ASN 335 ? B ASN 313 
130 1 Y 1 B PRO 336 ? B PRO 314 
131 1 Y 1 B SER 337 ? B SER 315 
132 1 Y 1 B HIS 338 ? B HIS 316 
133 1 Y 1 B GLY 339 ? B GLY 317 
134 1 Y 1 B GLN 340 ? B GLN 318 
135 1 Y 1 B GLU 341 ? B GLU 319 
136 1 Y 1 B TYR 342 ? B TYR 320 
137 1 Y 1 B ARG 343 ? B ARG 321 
138 1 Y 1 B SER 344 ? B SER 322 
139 1 Y 1 B VAL 345 ? B VAL 323 
140 1 Y 1 B ARG 346 ? B ARG 324 
141 1 Y 1 B LEU 347 ? B LEU 325 
142 1 Y 1 B ILE 348 ? B ILE 326 
143 1 Y 1 B TRP 349 ? B TRP 327 
144 1 Y 1 B LYS 350 ? B LYS 328 
145 1 Y 1 B ALA 351 ? B ALA 329 
146 1 Y 1 B LEU 352 ? B LEU 330 
147 1 Y 1 B PRO 353 ? B PRO 331 
148 1 Y 1 B LEU 354 ? B LEU 332 
149 1 Y 1 B SER 355 ? B SER 333 
150 1 Y 1 B GLU 356 ? B GLU 334 
151 1 Y 1 B ALA 357 ? B ALA 335 
152 1 Y 1 B ASN 358 ? B ASN 336 
153 1 Y 1 B GLY 359 ? B GLY 337 
154 1 Y 1 B LYS 360 ? B LYS 338 
155 1 Y 1 B ILE 361 ? B ILE 339 
156 1 Y 1 B LEU 362 ? B LEU 340 
157 1 Y 1 B ASP 363 ? B ASP 341 
158 1 Y 1 B TYR 364 ? B TYR 342 
159 1 Y 1 B GLU 365 ? B GLU 343 
160 1 Y 1 B VAL 366 ? B VAL 344 
161 1 Y 1 B ILE 367 ? B ILE 345 
162 1 Y 1 B LEU 368 ? B LEU 346 
163 1 Y 1 B THR 369 ? B THR 347 
164 1 Y 1 B GLN 370 ? B GLN 348 
165 1 Y 1 B SER 371 ? B SER 349 
166 1 Y 1 B LYS 372 ? B LYS 350 
167 1 Y 1 B SER 373 ? B SER 351 
168 1 Y 1 B VAL 374 ? B VAL 352 
169 1 Y 1 B SER 375 ? B SER 353 
170 1 Y 1 B GLN 376 ? B GLN 354 
171 1 Y 1 B THR 377 ? B THR 355 
172 1 Y 1 B TYR 378 ? B TYR 356 
173 1 Y 1 B THR 379 ? B THR 357 
174 1 Y 1 B VAL 380 ? B VAL 358 
175 1 Y 1 B THR 381 ? B THR 359 
176 1 Y 1 B GLY 382 ? B GLY 360 
177 1 Y 1 B THR 383 ? B THR 361 
178 1 Y 1 B GLU 384 ? B GLU 362 
179 1 Y 1 B LEU 385 ? B LEU 363 
180 1 Y 1 B THR 386 ? B THR 364 
181 1 Y 1 B VAL 387 ? B VAL 365 
182 1 Y 1 B ASN 388 ? B ASN 366 
183 1 Y 1 B LEU 389 ? B LEU 367 
184 1 Y 1 B THR 390 ? B THR 368 
185 1 Y 1 B ASN 391 ? B ASN 369 
186 1 Y 1 B ASP 392 ? B ASP 370 
187 1 Y 1 B ARG 393 ? B ARG 371 
188 1 Y 1 B TYR 394 ? B TYR 372 
189 1 Y 1 B VAL 395 ? B VAL 373 
190 1 Y 1 B ALA 396 ? B ALA 374 
191 1 Y 1 B SER 397 ? B SER 375 
192 1 Y 1 B LEU 398 ? B LEU 376 
193 1 Y 1 B ALA 399 ? B ALA 377 
194 1 Y 1 B ALA 400 ? B ALA 378 
195 1 Y 1 B ARG 401 ? B ARG 379 
196 1 Y 1 B ASN 402 ? B ASN 380 
197 1 Y 1 B LYS 403 ? B LYS 381 
198 1 Y 1 B VAL 404 ? B VAL 382 
199 1 Y 1 B GLY 405 ? B GLY 383 
200 1 Y 1 B LYS 406 ? B LYS 384 
201 1 Y 1 B SER 407 ? B SER 385 
202 1 Y 1 B ALA 408 ? B ALA 386 
203 1 Y 1 B ALA 409 ? B ALA 387 
204 1 Y 1 B ALA 410 ? B ALA 388 
205 1 Y 1 B VAL 411 ? B VAL 389 
206 1 Y 1 B LEU 412 ? B LEU 390 
207 1 Y 1 B THR 413 ? B THR 391 
208 1 Y 1 B ILE 414 ? B ILE 392 
209 1 Y 1 B PRO 415 ? B PRO 393 
210 1 Y 1 B SER 416 ? B SER 394 
211 1 Y 1 B PRO 417 ? B PRO 395 
212 1 Y 1 B HIS 418 ? B HIS 396 
213 1 Y 1 B VAL 419 ? B VAL 397 
214 1 Y 1 B THR 420 ? B THR 398 
215 1 Y 1 B ALA 421 ? B ALA 399 
216 1 Y 1 B ALA 422 ? B ALA 400 
217 1 Y 1 B TYR 423 ? B TYR 401 
218 1 Y 1 B SER 424 ? B SER 402 
219 1 Y 1 B VAL 425 ? B VAL 403 
220 1 Y 1 B VAL 426 ? B VAL 404 
221 1 Y 1 B ASN 427 ? B ASN 405 
222 1 Y 1 B LEU 428 ? B LEU 406 
223 1 Y 1 B LYS 429 ? B LYS 407 
224 1 Y 1 B ALA 430 ? B ALA 408 
225 1 Y 1 B PHE 431 ? B PHE 409 
226 1 Y 1 B PRO 432 ? B PRO 410 
227 1 Y 1 B LYS 433 ? B LYS 411 
228 1 Y 1 B ASP 434 ? B ASP 412 
229 1 Y 1 B ASN 435 ? B ASN 413 
230 1 Y 1 B LEU 436 ? B LEU 414 
231 1 Y 1 B LEU 437 ? B LEU 415 
232 1 Y 1 B TRP 438 ? B TRP 416 
233 1 Y 1 B VAL 439 ? B VAL 417 
234 1 Y 1 B GLU 440 ? B GLU 418 
235 1 Y 1 B TRP 441 ? B TRP 419 
236 1 Y 1 B THR 442 ? B THR 420 
237 1 Y 1 B PRO 443 ? B PRO 421 
238 1 Y 1 B PRO 444 ? B PRO 422 
239 1 Y 1 B PRO 445 ? B PRO 423 
240 1 Y 1 B LYS 446 ? B LYS 424 
241 1 Y 1 B PRO 447 ? B PRO 425 
242 1 Y 1 B VAL 448 ? B VAL 426 
243 1 Y 1 B SER 449 ? B SER 427 
244 1 Y 1 B LYS 450 ? B LYS 428 
245 1 Y 1 B TYR 451 ? B TYR 429 
246 1 Y 1 B ILE 452 ? B ILE 430 
247 1 Y 1 B LEU 453 ? B LEU 431 
248 1 Y 1 B GLU 454 ? B GLU 432 
249 1 Y 1 B TRP 455 ? B TRP 433 
250 1 Y 1 B CYS 456 ? B CYS 434 
251 1 Y 1 B VAL 457 ? B VAL 435 
252 1 Y 1 B LEU 458 ? B LEU 436 
253 1 Y 1 B SER 459 ? B SER 437 
254 1 Y 1 B GLU 460 ? B GLU 438 
255 1 Y 1 B ASN 461 ? B ASN 439 
256 1 Y 1 B ALA 462 ? B ALA 440 
257 1 Y 1 B PRO 463 ? B PRO 441 
258 1 Y 1 B CYS 464 ? B CYS 442 
259 1 Y 1 B VAL 465 ? B VAL 443 
260 1 Y 1 B GLU 466 ? B GLU 444 
261 1 Y 1 B ASP 467 ? B ASP 445 
262 1 Y 1 B TRP 468 ? B TRP 446 
263 1 Y 1 B GLN 469 ? B GLN 447 
264 1 Y 1 B GLN 470 ? B GLN 448 
265 1 Y 1 B GLU 471 ? B GLU 449 
266 1 Y 1 B ASP 472 ? B ASP 450 
267 1 Y 1 B ALA 473 ? B ALA 451 
268 1 Y 1 B THR 474 ? B THR 452 
269 1 Y 1 B VAL 475 ? B VAL 453 
270 1 Y 1 B ASN 476 ? B ASN 454 
271 1 Y 1 B ARG 477 ? B ARG 455 
272 1 Y 1 B THR 478 ? B THR 456 
273 1 Y 1 B HIS 479 ? B HIS 457 
274 1 Y 1 B LEU 480 ? B LEU 458 
275 1 Y 1 B ARG 481 ? B ARG 459 
276 1 Y 1 B GLY 482 ? B GLY 460 
277 1 Y 1 B ARG 483 ? B ARG 461 
278 1 Y 1 B LEU 484 ? B LEU 462 
279 1 Y 1 B LEU 485 ? B LEU 463 
280 1 Y 1 B GLU 486 ? B GLU 464 
281 1 Y 1 B SER 487 ? B SER 465 
282 1 Y 1 B LYS 488 ? B LYS 466 
283 1 Y 1 B CYS 489 ? B CYS 467 
284 1 Y 1 B TYR 490 ? B TYR 468 
285 1 Y 1 B GLN 491 ? B GLN 469 
286 1 Y 1 B ILE 492 ? B ILE 470 
287 1 Y 1 B THR 493 ? B THR 471 
288 1 Y 1 B VAL 494 ? B VAL 472 
289 1 Y 1 B THR 495 ? B THR 473 
290 1 Y 1 B PRO 496 ? B PRO 474 
291 1 Y 1 B VAL 497 ? B VAL 475 
292 1 Y 1 B PHE 498 ? B PHE 476 
293 1 Y 1 B ALA 499 ? B ALA 477 
294 1 Y 1 B THR 500 ? B THR 478 
295 1 Y 1 B GLY 501 ? B GLY 479 
296 1 Y 1 B PRO 502 ? B PRO 480 
297 1 Y 1 B GLY 503 ? B GLY 481 
298 1 Y 1 B GLY 504 ? B GLY 482 
299 1 Y 1 B SER 505 ? B SER 483 
300 1 Y 1 B GLU 506 ? B GLU 484 
301 1 Y 1 B SER 507 ? B SER 485 
302 1 Y 1 B LEU 508 ? B LEU 486 
303 1 Y 1 B LYS 509 ? B LYS 487 
304 1 Y 1 B ALA 510 ? B ALA 488 
305 1 Y 1 B TYR 511 ? B TYR 489 
306 1 Y 1 B LEU 512 ? B LEU 490 
307 1 Y 1 B LYS 513 ? B LYS 491 
308 1 Y 1 B GLN 514 ? B GLN 492 
309 1 Y 1 B ALA 515 ? B ALA 493 
310 1 Y 1 B ALA 516 ? B ALA 494 
311 1 Y 1 B PRO 517 ? B PRO 495 
312 1 Y 1 B ALA 518 ? B ALA 496 
313 1 Y 1 B ARG 519 ? B ARG 497 
314 1 Y 1 B GLY 520 ? B GLY 498 
315 1 Y 1 B PRO 521 ? B PRO 499 
316 1 Y 1 B THR 522 ? B THR 500 
317 1 Y 1 B VAL 523 ? B VAL 501 
318 1 Y 1 B ARG 524 ? B ARG 502 
319 1 Y 1 B THR 525 ? B THR 503 
320 1 Y 1 B LYS 526 ? B LYS 504 
321 1 Y 1 B LYS 527 ? B LYS 505 
322 1 Y 1 B VAL 528 ? B VAL 506 
323 1 Y 1 B GLY 529 ? B GLY 507 
324 1 Y 1 B LYS 530 ? B LYS 508 
325 1 Y 1 B ASN 531 ? B ASN 509 
326 1 Y 1 B GLU 532 ? B GLU 510 
327 1 Y 1 B ALA 533 ? B ALA 511 
328 1 Y 1 B VAL 534 ? B VAL 512 
329 1 Y 1 B LEU 535 ? B LEU 513 
330 1 Y 1 B ALA 536 ? B ALA 514 
331 1 Y 1 B TRP 537 ? B TRP 515 
332 1 Y 1 B ASP 538 ? B ASP 516 
333 1 Y 1 B GLN 539 ? B GLN 517 
334 1 Y 1 B ILE 540 ? B ILE 518 
335 1 Y 1 B PRO 541 ? B PRO 519 
336 1 Y 1 B VAL 542 ? B VAL 520 
337 1 Y 1 B ASP 543 ? B ASP 521 
338 1 Y 1 B ASP 544 ? B ASP 522 
339 1 Y 1 B GLN 545 ? B GLN 523 
340 1 Y 1 B ASN 546 ? B ASN 524 
341 1 Y 1 B GLY 547 ? B GLY 525 
342 1 Y 1 B PHE 548 ? B PHE 526 
343 1 Y 1 B ILE 549 ? B ILE 527 
344 1 Y 1 B ARG 550 ? B ARG 528 
345 1 Y 1 B ASN 551 ? B ASN 529 
346 1 Y 1 B TYR 552 ? B TYR 530 
347 1 Y 1 B SER 553 ? B SER 531 
348 1 Y 1 B ILE 554 ? B ILE 532 
349 1 Y 1 B SER 555 ? B SER 533 
350 1 Y 1 B TYR 556 ? B TYR 534 
351 1 Y 1 B ARG 557 ? B ARG 535 
352 1 Y 1 B THR 558 ? B THR 536 
353 1 Y 1 B SER 559 ? B SER 537 
354 1 Y 1 B VAL 560 ? B VAL 538 
355 1 Y 1 B GLY 561 ? B GLY 539 
356 1 Y 1 B LYS 562 ? B LYS 540 
357 1 Y 1 B GLU 563 ? B GLU 541 
358 1 Y 1 B MET 564 ? B MET 542 
359 1 Y 1 B VAL 565 ? B VAL 543 
360 1 Y 1 B VAL 566 ? B VAL 544 
361 1 Y 1 B HIS 567 ? B HIS 545 
362 1 Y 1 B VAL 568 ? B VAL 546 
363 1 Y 1 B ASP 569 ? B ASP 547 
364 1 Y 1 B SER 570 ? B SER 548 
365 1 Y 1 B SER 571 ? B SER 549 
366 1 Y 1 B HIS 572 ? B HIS 550 
367 1 Y 1 B THR 573 ? B THR 551 
368 1 Y 1 B GLU 574 ? B GLU 552 
369 1 Y 1 B TYR 575 ? B TYR 553 
370 1 Y 1 B THR 576 ? B THR 554 
371 1 Y 1 B LEU 577 ? B LEU 555 
372 1 Y 1 B SER 578 ? B SER 556 
373 1 Y 1 B SER 579 ? B SER 557 
374 1 Y 1 B LEU 580 ? B LEU 558 
375 1 Y 1 B SER 581 ? B SER 559 
376 1 Y 1 B SER 582 ? B SER 560 
377 1 Y 1 B ASP 583 ? B ASP 561 
378 1 Y 1 B THR 584 ? B THR 562 
379 1 Y 1 B LEU 585 ? B LEU 563 
380 1 Y 1 B TYR 586 ? B TYR 564 
381 1 Y 1 B MET 587 ? B MET 565 
382 1 Y 1 B VAL 588 ? B VAL 566 
383 1 Y 1 B ARG 589 ? B ARG 567 
384 1 Y 1 B MET 590 ? B MET 568 
385 1 Y 1 B ALA 591 ? B ALA 569 
386 1 Y 1 B ALA 592 ? B ALA 570 
387 1 Y 1 B TYR 593 ? B TYR 571 
388 1 Y 1 B THR 594 ? B THR 572 
389 1 Y 1 B ASP 595 ? B ASP 573 
390 1 Y 1 B GLU 596 ? B GLU 574 
391 1 Y 1 B GLY 597 ? B GLY 575 
392 1 Y 1 B GLY 598 ? B GLY 576 
393 1 Y 1 B LYS 599 ? B LYS 577 
394 1 Y 1 B ASP 600 ? B ASP 578 
395 1 Y 1 B GLY 601 ? B GLY 579 
396 1 Y 1 B PRO 602 ? B PRO 580 
397 1 Y 1 B GLU 603 ? B GLU 581 
398 1 Y 1 B PHE 604 ? B PHE 582 
399 1 Y 1 B THR 605 ? B THR 583 
400 1 Y 1 B PHE 606 ? B PHE 584 
401 1 Y 1 B THR 607 ? B THR 585 
402 1 Y 1 B THR 608 ? B THR 586 
403 1 Y 1 B PRO 609 ? B PRO 587 
404 1 Y 1 B LYS 610 ? B LYS 588 
405 1 Y 1 B PHE 611 ? B PHE 589 
406 1 Y 1 B ALA 612 ? B ALA 590 
407 1 Y 1 B GLN 613 ? B GLN 591 
408 1 Y 1 B GLY 614 ? B GLY 592 
409 1 Y 1 B GLU 615 ? B GLU 593 
410 1 Y 1 B ILE 616 ? B ILE 594 
411 1 Y 1 B GLU 617 ? B GLU 595 
412 1 Y 1 B GLU 618 ? B GLU 596 
413 1 Y 1 B GLN 619 ? B GLN 597 
414 1 Y 1 B LYS 620 ? B LYS 598 
415 1 Y 1 B LEU 621 ? B LEU 599 
416 1 Y 1 B ILE 622 ? B ILE 600 
417 1 Y 1 B SER 623 ? B SER 601 
418 1 Y 1 B GLU 624 ? B GLU 602 
419 1 Y 1 B GLU 625 ? B GLU 603 
420 1 Y 1 B ASP 626 ? B ASP 604 
421 1 Y 1 B LEU 627 ? B LEU 605 
422 1 Y 1 B GLY 628 ? B GLY 606 
423 1 Y 1 B GLY 629 ? B GLY 607 
424 1 Y 1 B GLU 630 ? B GLU 608 
425 1 Y 1 B GLN 631 ? B GLN 609 
426 1 Y 1 B LYS 632 ? B LYS 610 
427 1 Y 1 B LEU 633 ? B LEU 611 
428 1 Y 1 B ILE 634 ? B ILE 612 
429 1 Y 1 B SER 635 ? B SER 613 
430 1 Y 1 B GLU 636 ? B GLU 614 
431 1 Y 1 B GLU 637 ? B GLU 615 
432 1 Y 1 B ASP 638 ? B ASP 616 
433 1 Y 1 B LEU 639 ? B LEU 617 
434 1 Y 1 B HIS 640 ? B HIS 618 
435 1 Y 1 B HIS 641 ? B HIS 619 
436 1 Y 1 B HIS 642 ? B HIS 620 
437 1 Y 1 B HIS 643 ? B HIS 621 
438 1 Y 1 B HIS 644 ? B HIS 622 
439 1 Y 1 B HIS 645 ? B HIS 623 
440 1 Y 1 C GLU 24  ? C GLU 1   
441 1 Y 1 C VAL 25  ? C VAL 2   
442 1 Y 1 C LEU 26  ? C LEU 3   
443 1 Y 1 C GLU 27  ? C GLU 4   
444 1 Y 1 C GLU 28  ? C GLU 5   
445 1 Y 1 C PRO 29  ? C PRO 6   
446 1 Y 1 C LEU 30  ? C LEU 7   
447 1 Y 1 C PRO 31  ? C PRO 8   
448 1 Y 1 C LEU 32  ? C LEU 9   
449 1 Y 1 C THR 33  ? C THR 10  
450 1 Y 1 C PRO 34  ? C PRO 11  
451 1 Y 1 C GLU 35  ? C GLU 12  
452 1 Y 1 C ILE 36  ? C ILE 13  
453 1 Y 1 C HIS 37  ? C HIS 14  
454 1 Y 1 C LYS 38  ? C LYS 15  
455 1 Y 1 C VAL 39  ? C VAL 16  
456 1 Y 1 C SER 40  ? C SER 17  
457 1 Y 1 C PHE 41  ? C PHE 18  
458 1 Y 1 C GLN 42  ? C GLN 19  
459 1 Y 1 C LEU 43  ? C LEU 20  
460 1 Y 1 C LYS 44  ? C LYS 21  
461 1 Y 1 C LEU 45  ? C LEU 22  
462 1 Y 1 C GLN 46  ? C GLN 23  
463 1 Y 1 C GLU 47  ? C GLU 24  
464 1 Y 1 C VAL 48  ? C VAL 25  
465 1 Y 1 C ASN 49  ? C ASN 26  
466 1 Y 1 C LEU 50  ? C LEU 27  
467 1 Y 1 C GLU 51  ? C GLU 28  
468 1 Y 1 C TRP 52  ? C TRP 29  
469 1 Y 1 C THR 53  ? C THR 30  
470 1 Y 1 C VAL 54  ? C VAL 31  
471 1 Y 1 C PRO 55  ? C PRO 32  
472 1 Y 1 C ALA 56  ? C ALA 33  
473 1 Y 1 C LEU 57  ? C LEU 34  
474 1 Y 1 C THR 58  ? C THR 35  
475 1 Y 1 C HIS 59  ? C HIS 36  
476 1 Y 1 C GLU 60  ? C GLU 37  
477 1 Y 1 C GLU 61  ? C GLU 38  
478 1 Y 1 C LEU 62  ? C LEU 39  
479 1 Y 1 C ASN 63  ? C ASN 40  
480 1 Y 1 C MET 64  ? C MET 41  
481 1 Y 1 C ILE 65  ? C ILE 42  
482 1 Y 1 C PHE 66  ? C PHE 43  
483 1 Y 1 C GLN 67  ? C GLN 44  
484 1 Y 1 C ILE 68  ? C ILE 45  
485 1 Y 1 C GLU 69  ? C GLU 46  
486 1 Y 1 C ILE 70  ? C ILE 47  
487 1 Y 1 C SER 71  ? C SER 48  
488 1 Y 1 C ARG 72  ? C ARG 49  
489 1 Y 1 C LEU 73  ? C LEU 50  
490 1 Y 1 C ASN 74  ? C ASN 51  
491 1 Y 1 C ILE 75  ? C ILE 52  
492 1 Y 1 C SER 76  ? C SER 53  
493 1 Y 1 C ASN 77  ? C ASN 54  
494 1 Y 1 C THR 78  ? C THR 55  
495 1 Y 1 C ILE 79  ? C ILE 56  
496 1 Y 1 C TRP 80  ? C TRP 57  
497 1 Y 1 C VAL 81  ? C VAL 58  
498 1 Y 1 C GLU 82  ? C GLU 59  
499 1 Y 1 C ASN 83  ? C ASN 60  
500 1 Y 1 C TYR 84  ? C TYR 61  
501 1 Y 1 C SER 85  ? C SER 62  
502 1 Y 1 C THR 86  ? C THR 63  
503 1 Y 1 C THR 87  ? C THR 64  
504 1 Y 1 C VAL 88  ? C VAL 65  
505 1 Y 1 C LYS 89  ? C LYS 66  
506 1 Y 1 C ARG 90  ? C ARG 67  
507 1 Y 1 C GLU 91  ? C GLU 68  
508 1 Y 1 C GLU 92  ? C GLU 69  
509 1 Y 1 C ALA 93  ? C ALA 70  
510 1 Y 1 C VAL 94  ? C VAL 71  
511 1 Y 1 C ARG 95  ? C ARG 72  
512 1 Y 1 C TRP 96  ? C TRP 73  
513 1 Y 1 C ASN 97  ? C ASN 74  
514 1 Y 1 C TRP 98  ? C TRP 75  
515 1 Y 1 C THR 99  ? C THR 76  
516 1 Y 1 C SER 100 ? C SER 77  
517 1 Y 1 C ASP 101 ? C ASP 78  
518 1 Y 1 C ILE 102 ? C ILE 79  
519 1 Y 1 C PRO 103 ? C PRO 80  
520 1 Y 1 C LEU 104 ? C LEU 81  
521 1 Y 1 C GLU 105 ? C GLU 82  
522 1 Y 1 C CYS 106 ? C CYS 83  
523 1 Y 1 C VAL 107 ? C VAL 84  
524 1 Y 1 C LYS 108 ? C LYS 85  
525 1 Y 1 C HIS 109 ? C HIS 86  
526 1 Y 1 C PHE 110 ? C PHE 87  
527 1 Y 1 C ILE 111 ? C ILE 88  
528 1 Y 1 C ARG 112 ? C ARG 89  
529 1 Y 1 C ILE 113 ? C ILE 90  
530 1 Y 1 C ARG 114 ? C ARG 91  
531 1 Y 1 C ALA 115 ? C ALA 92  
532 1 Y 1 C LEU 116 ? C LEU 93  
533 1 Y 1 C VAL 117 ? C VAL 94  
534 1 Y 1 C ASP 118 ? C ASP 95  
535 1 Y 1 C ASP 119 ? C ASP 96  
536 1 Y 1 C THR 120 ? C THR 97  
537 1 Y 1 C LYS 121 ? C LYS 98  
538 1 Y 1 C SER 122 ? C SER 99  
539 1 Y 1 C LEU 123 ? C LEU 100 
540 1 Y 1 C PRO 124 ? C PRO 101 
541 1 Y 1 C GLN 125 ? C GLN 102 
542 1 Y 1 C SER 126 ? C SER 103 
543 1 Y 1 C SER 127 ? C SER 104 
544 1 Y 1 C TRP 128 ? C TRP 105 
545 1 Y 1 C GLY 129 ? C GLY 106 
546 1 Y 1 C ASN 130 ? C ASN 107 
547 1 Y 1 C TRP 131 ? C TRP 108 
548 1 Y 1 C SER 132 ? C SER 109 
549 1 Y 1 C SER 133 ? C SER 110 
550 1 Y 1 C TRP 134 ? C TRP 111 
551 1 Y 1 C LYS 135 ? C LYS 112 
552 1 Y 1 C GLU 136 ? C GLU 113 
553 1 Y 1 C VAL 137 ? C VAL 114 
554 1 Y 1 C ASN 138 ? C ASN 115 
555 1 Y 1 C ALA 139 ? C ALA 116 
556 1 Y 1 C LYS 140 ? C LYS 117 
557 1 Y 1 C VAL 141 ? C VAL 118 
558 1 Y 1 C SER 142 ? C SER 119 
559 1 Y 1 C VAL 143 ? C VAL 120 
560 1 Y 1 C VAL 328 ? C VAL 305 
561 1 Y 1 C HIS 329 ? C HIS 306 
562 1 Y 1 C PRO 330 ? C PRO 307 
563 1 Y 1 C LYS 331 ? C LYS 308 
564 1 Y 1 C ALA 332 ? C ALA 309 
565 1 Y 1 C PRO 333 ? C PRO 310 
566 1 Y 1 C GLN 334 ? C GLN 311 
567 1 Y 1 C ASP 335 ? C ASP 312 
568 1 Y 1 C VAL 336 ? C VAL 313 
569 1 Y 1 C THR 337 ? C THR 314 
570 1 Y 1 C LEU 338 ? C LEU 315 
571 1 Y 1 C LYS 339 ? C LYS 316 
572 1 Y 1 C ILE 340 ? C ILE 317 
573 1 Y 1 C ILE 341 ? C ILE 318 
574 1 Y 1 C GLY 342 ? C GLY 319 
575 1 Y 1 C ALA 343 ? C ALA 320 
576 1 Y 1 C THR 344 ? C THR 321 
577 1 Y 1 C LYS 345 ? C LYS 322 
578 1 Y 1 C ALA 346 ? C ALA 323 
579 1 Y 1 C ASN 347 ? C ASN 324 
580 1 Y 1 C MET 348 ? C MET 325 
581 1 Y 1 C THR 349 ? C THR 326 
582 1 Y 1 C TRP 350 ? C TRP 327 
583 1 Y 1 C LYS 351 ? C LYS 328 
584 1 Y 1 C VAL 352 ? C VAL 329 
585 1 Y 1 C HIS 353 ? C HIS 330 
586 1 Y 1 C SER 354 ? C SER 331 
587 1 Y 1 C HIS 355 ? C HIS 332 
588 1 Y 1 C GLY 356 ? C GLY 333 
589 1 Y 1 C ASN 357 ? C ASN 334 
590 1 Y 1 C ASN 358 ? C ASN 335 
591 1 Y 1 C TYR 359 ? C TYR 336 
592 1 Y 1 C THR 360 ? C THR 337 
593 1 Y 1 C LEU 361 ? C LEU 338 
594 1 Y 1 C LEU 362 ? C LEU 339 
595 1 Y 1 C CYS 363 ? C CYS 340 
596 1 Y 1 C GLN 364 ? C GLN 341 
597 1 Y 1 C VAL 365 ? C VAL 342 
598 1 Y 1 C LYS 366 ? C LYS 343 
599 1 Y 1 C LEU 367 ? C LEU 344 
600 1 Y 1 C GLN 368 ? C GLN 345 
601 1 Y 1 C TYR 369 ? C TYR 346 
602 1 Y 1 C GLY 370 ? C GLY 347 
603 1 Y 1 C GLU 371 ? C GLU 348 
604 1 Y 1 C VAL 372 ? C VAL 349 
605 1 Y 1 C ILE 373 ? C ILE 350 
606 1 Y 1 C HIS 374 ? C HIS 351 
607 1 Y 1 C GLU 375 ? C GLU 352 
608 1 Y 1 C HIS 376 ? C HIS 353 
609 1 Y 1 C ASN 377 ? C ASN 354 
610 1 Y 1 C VAL 378 ? C VAL 355 
611 1 Y 1 C SER 379 ? C SER 356 
612 1 Y 1 C VAL 380 ? C VAL 357 
613 1 Y 1 C HIS 381 ? C HIS 358 
614 1 Y 1 C MET 382 ? C MET 359 
615 1 Y 1 C SER 383 ? C SER 360 
616 1 Y 1 C ALA 384 ? C ALA 361 
617 1 Y 1 C ASN 385 ? C ASN 362 
618 1 Y 1 C TYR 386 ? C TYR 363 
619 1 Y 1 C LEU 387 ? C LEU 364 
620 1 Y 1 C PHE 388 ? C PHE 365 
621 1 Y 1 C SER 389 ? C SER 366 
622 1 Y 1 C ASP 390 ? C ASP 367 
623 1 Y 1 C LEU 391 ? C LEU 368 
624 1 Y 1 C ASP 392 ? C ASP 369 
625 1 Y 1 C PRO 393 ? C PRO 370 
626 1 Y 1 C ASP 394 ? C ASP 371 
627 1 Y 1 C THR 395 ? C THR 372 
628 1 Y 1 C LYS 396 ? C LYS 373 
629 1 Y 1 C TYR 397 ? C TYR 374 
630 1 Y 1 C LYS 398 ? C LYS 375 
631 1 Y 1 C ALA 399 ? C ALA 376 
632 1 Y 1 C PHE 400 ? C PHE 377 
633 1 Y 1 C VAL 401 ? C VAL 378 
634 1 Y 1 C ARG 402 ? C ARG 379 
635 1 Y 1 C CYS 403 ? C CYS 380 
636 1 Y 1 C ALA 404 ? C ALA 381 
637 1 Y 1 C SER 405 ? C SER 382 
638 1 Y 1 C ALA 406 ? C ALA 383 
639 1 Y 1 C ASN 407 ? C ASN 384 
640 1 Y 1 C HIS 408 ? C HIS 385 
641 1 Y 1 C PHE 409 ? C PHE 386 
642 1 Y 1 C TRP 410 ? C TRP 387 
643 1 Y 1 C LYS 411 ? C LYS 388 
644 1 Y 1 C TRP 412 ? C TRP 389 
645 1 Y 1 C SER 413 ? C SER 390 
646 1 Y 1 C ASP 414 ? C ASP 391 
647 1 Y 1 C TRP 415 ? C TRP 392 
648 1 Y 1 C THR 416 ? C THR 393 
649 1 Y 1 C GLN 417 ? C GLN 394 
650 1 Y 1 C LYS 418 ? C LYS 395 
651 1 Y 1 C GLU 419 ? C GLU 396 
652 1 Y 1 C PHE 420 ? C PHE 397 
653 1 Y 1 C SER 421 ? C SER 398 
654 1 Y 1 C THR 422 ? C THR 399 
655 1 Y 1 C PRO 423 ? C PRO 400 
656 1 Y 1 C GLU 424 ? C GLU 401 
657 1 Y 1 C THR 425 ? C THR 402 
658 1 Y 1 C ALA 426 ? C ALA 403 
659 1 Y 1 C PRO 427 ? C PRO 404 
660 1 Y 1 C SER 428 ? C SER 405 
661 1 Y 1 C GLN 429 ? C GLN 406 
662 1 Y 1 C ALA 430 ? C ALA 407 
663 1 Y 1 C LEU 431 ? C LEU 408 
664 1 Y 1 C ASP 432 ? C ASP 409 
665 1 Y 1 C VAL 433 ? C VAL 410 
666 1 Y 1 C TRP 434 ? C TRP 411 
667 1 Y 1 C ARG 435 ? C ARG 412 
668 1 Y 1 C GLN 436 ? C GLN 413 
669 1 Y 1 C VAL 437 ? C VAL 414 
670 1 Y 1 C TRP 438 ? C TRP 415 
671 1 Y 1 C SER 439 ? C SER 416 
672 1 Y 1 C GLU 440 ? C GLU 417 
673 1 Y 1 C ASN 441 ? C ASN 418 
674 1 Y 1 C GLY 442 ? C GLY 419 
675 1 Y 1 C ARG 443 ? C ARG 420 
676 1 Y 1 C ARG 444 ? C ARG 421 
677 1 Y 1 C ILE 445 ? C ILE 422 
678 1 Y 1 C VAL 446 ? C VAL 423 
679 1 Y 1 C THR 447 ? C THR 424 
680 1 Y 1 C LEU 448 ? C LEU 425 
681 1 Y 1 C PHE 449 ? C PHE 426 
682 1 Y 1 C TRP 450 ? C TRP 427 
683 1 Y 1 C LYS 451 ? C LYS 428 
684 1 Y 1 C PRO 452 ? C PRO 429 
685 1 Y 1 C LEU 453 ? C LEU 430 
686 1 Y 1 C LEU 454 ? C LEU 431 
687 1 Y 1 C LYS 455 ? C LYS 432 
688 1 Y 1 C SER 456 ? C SER 433 
689 1 Y 1 C GLN 457 ? C GLN 434 
690 1 Y 1 C ALA 458 ? C ALA 435 
691 1 Y 1 C ASN 459 ? C ASN 436 
692 1 Y 1 C GLY 460 ? C GLY 437 
693 1 Y 1 C LYS 461 ? C LYS 438 
694 1 Y 1 C ILE 462 ? C ILE 439 
695 1 Y 1 C ILE 463 ? C ILE 440 
696 1 Y 1 C SER 464 ? C SER 441 
697 1 Y 1 C TYR 465 ? C TYR 442 
698 1 Y 1 C ASN 466 ? C ASN 443 
699 1 Y 1 C ILE 467 ? C ILE 444 
700 1 Y 1 C VAL 468 ? C VAL 445 
701 1 Y 1 C VAL 469 ? C VAL 446 
702 1 Y 1 C GLU 470 ? C GLU 447 
703 1 Y 1 C ASN 471 ? C ASN 448 
704 1 Y 1 C GLU 472 ? C GLU 449 
705 1 Y 1 C ALA 473 ? C ALA 450 
706 1 Y 1 C LYS 474 ? C LYS 451 
707 1 Y 1 C PRO 475 ? C PRO 452 
708 1 Y 1 C THR 476 ? C THR 453 
709 1 Y 1 C GLU 477 ? C GLU 454 
710 1 Y 1 C SER 478 ? C SER 455 
711 1 Y 1 C GLU 479 ? C GLU 456 
712 1 Y 1 C HIS 480 ? C HIS 457 
713 1 Y 1 C TYR 481 ? C TYR 458 
714 1 Y 1 C CYS 482 ? C CYS 459 
715 1 Y 1 C VAL 483 ? C VAL 460 
716 1 Y 1 C TRP 484 ? C TRP 461 
717 1 Y 1 C ALA 485 ? C ALA 462 
718 1 Y 1 C PRO 486 ? C PRO 463 
719 1 Y 1 C ALA 487 ? C ALA 464 
720 1 Y 1 C LEU 488 ? C LEU 465 
721 1 Y 1 C SER 489 ? C SER 466 
722 1 Y 1 C THR 490 ? C THR 467 
723 1 Y 1 C ASN 491 ? C ASN 468 
724 1 Y 1 C LEU 492 ? C LEU 469 
725 1 Y 1 C SER 493 ? C SER 470 
726 1 Y 1 C LEU 494 ? C LEU 471 
727 1 Y 1 C ASP 495 ? C ASP 472 
728 1 Y 1 C LEU 496 ? C LEU 473 
729 1 Y 1 C GLN 497 ? C GLN 474 
730 1 Y 1 C PRO 498 ? C PRO 475 
731 1 Y 1 C TYR 499 ? C TYR 476 
732 1 Y 1 C LYS 500 ? C LYS 477 
733 1 Y 1 C ILE 501 ? C ILE 478 
734 1 Y 1 C ARG 502 ? C ARG 479 
735 1 Y 1 C ILE 503 ? C ILE 480 
736 1 Y 1 C THR 504 ? C THR 481 
737 1 Y 1 C THR 505 ? C THR 482 
738 1 Y 1 C ASN 506 ? C ASN 483 
739 1 Y 1 C ASN 507 ? C ASN 484 
740 1 Y 1 C SER 508 ? C SER 485 
741 1 Y 1 C MET 509 ? C MET 486 
742 1 Y 1 C GLY 510 ? C GLY 487 
743 1 Y 1 C ALA 511 ? C ALA 488 
744 1 Y 1 C SER 512 ? C SER 489 
745 1 Y 1 C PRO 513 ? C PRO 490 
746 1 Y 1 C GLU 514 ? C GLU 491 
747 1 Y 1 C SER 515 ? C SER 492 
748 1 Y 1 C LEU 516 ? C LEU 493 
749 1 Y 1 C MET 517 ? C MET 494 
750 1 Y 1 C VAL 518 ? C VAL 495 
751 1 Y 1 C LEU 519 ? C LEU 496 
752 1 Y 1 C SER 520 ? C SER 497 
753 1 Y 1 C ASN 521 ? C ASN 498 
754 1 Y 1 C ASP 522 ? C ASP 499 
755 1 Y 1 C SER 523 ? C SER 500 
756 1 Y 1 C GLY 524 ? C GLY 501 
757 1 Y 1 C HIS 525 ? C HIS 502 
758 1 Y 1 C GLU 526 ? C GLU 503 
759 1 Y 1 C GLU 527 ? C GLU 504 
760 1 Y 1 C VAL 528 ? C VAL 505 
761 1 Y 1 C LYS 529 ? C LYS 506 
762 1 Y 1 C GLU 530 ? C GLU 507 
763 1 Y 1 C LYS 531 ? C LYS 508 
764 1 Y 1 C THR 532 ? C THR 509 
765 1 Y 1 C ILE 533 ? C ILE 510 
766 1 Y 1 C LYS 534 ? C LYS 511 
767 1 Y 1 C GLY 535 ? C GLY 512 
768 1 Y 1 C ILE 536 ? C ILE 513 
769 1 Y 1 C LYS 537 ? C LYS 514 
770 1 Y 1 C ASP 538 ? C ASP 515 
771 1 Y 1 C ALA 539 ? C ALA 516 
772 1 Y 1 C PHE 540 ? C PHE 517 
773 1 Y 1 C ASN 541 ? C ASN 518 
774 1 Y 1 C ILE 542 ? C ILE 519 
775 1 Y 1 C SER 543 ? C SER 520 
776 1 Y 1 C TRP 544 ? C TRP 521 
777 1 Y 1 C GLU 545 ? C GLU 522 
778 1 Y 1 C PRO 546 ? C PRO 523 
779 1 Y 1 C VAL 547 ? C VAL 524 
780 1 Y 1 C SER 548 ? C SER 525 
781 1 Y 1 C GLY 549 ? C GLY 526 
782 1 Y 1 C ASP 550 ? C ASP 527 
783 1 Y 1 C THR 551 ? C THR 528 
784 1 Y 1 C MET 552 ? C MET 529 
785 1 Y 1 C GLY 553 ? C GLY 530 
786 1 Y 1 C TYR 554 ? C TYR 531 
787 1 Y 1 C VAL 555 ? C VAL 532 
788 1 Y 1 C VAL 556 ? C VAL 533 
789 1 Y 1 C ASP 557 ? C ASP 534 
790 1 Y 1 C TRP 558 ? C TRP 535 
791 1 Y 1 C CYS 559 ? C CYS 536 
792 1 Y 1 C ALA 560 ? C ALA 537 
793 1 Y 1 C HIS 561 ? C HIS 538 
794 1 Y 1 C SER 562 ? C SER 539 
795 1 Y 1 C GLN 563 ? C GLN 540 
796 1 Y 1 C ASP 564 ? C ASP 541 
797 1 Y 1 C GLN 565 ? C GLN 542 
798 1 Y 1 C ARG 566 ? C ARG 543 
799 1 Y 1 C CYS 567 ? C CYS 544 
800 1 Y 1 C ASP 568 ? C ASP 545 
801 1 Y 1 C LEU 569 ? C LEU 546 
802 1 Y 1 C GLN 570 ? C GLN 547 
803 1 Y 1 C TRP 571 ? C TRP 548 
804 1 Y 1 C LYS 572 ? C LYS 549 
805 1 Y 1 C ASN 573 ? C ASN 550 
806 1 Y 1 C LEU 574 ? C LEU 551 
807 1 Y 1 C GLY 575 ? C GLY 552 
808 1 Y 1 C PRO 576 ? C PRO 553 
809 1 Y 1 C ASN 577 ? C ASN 554 
810 1 Y 1 C THR 578 ? C THR 555 
811 1 Y 1 C THR 579 ? C THR 556 
812 1 Y 1 C SER 580 ? C SER 557 
813 1 Y 1 C THR 581 ? C THR 558 
814 1 Y 1 C THR 582 ? C THR 559 
815 1 Y 1 C ILE 583 ? C ILE 560 
816 1 Y 1 C THR 584 ? C THR 561 
817 1 Y 1 C SER 585 ? C SER 562 
818 1 Y 1 C ASP 586 ? C ASP 563 
819 1 Y 1 C ASP 587 ? C ASP 564 
820 1 Y 1 C PHE 588 ? C PHE 565 
821 1 Y 1 C LYS 589 ? C LYS 566 
822 1 Y 1 C PRO 590 ? C PRO 567 
823 1 Y 1 C GLY 591 ? C GLY 568 
824 1 Y 1 C VAL 592 ? C VAL 569 
825 1 Y 1 C ARG 593 ? C ARG 570 
826 1 Y 1 C TYR 594 ? C TYR 571 
827 1 Y 1 C ASN 595 ? C ASN 572 
828 1 Y 1 C PHE 596 ? C PHE 573 
829 1 Y 1 C ARG 597 ? C ARG 574 
830 1 Y 1 C ILE 598 ? C ILE 575 
831 1 Y 1 C PHE 599 ? C PHE 576 
832 1 Y 1 C GLU 600 ? C GLU 577 
833 1 Y 1 C ARG 601 ? C ARG 578 
834 1 Y 1 C SER 602 ? C SER 579 
835 1 Y 1 C VAL 603 ? C VAL 580 
836 1 Y 1 C GLU 604 ? C GLU 581 
837 1 Y 1 C HIS 605 ? C HIS 582 
838 1 Y 1 C LYS 606 ? C LYS 583 
839 1 Y 1 C ALA 607 ? C ALA 584 
840 1 Y 1 C ARG 608 ? C ARG 585 
841 1 Y 1 C LEU 609 ? C LEU 586 
842 1 Y 1 C VAL 610 ? C VAL 587 
843 1 Y 1 C GLU 611 ? C GLU 588 
844 1 Y 1 C LYS 612 ? C LYS 589 
845 1 Y 1 C GLN 613 ? C GLN 590 
846 1 Y 1 C ARG 614 ? C ARG 591 
847 1 Y 1 C GLY 615 ? C GLY 592 
848 1 Y 1 C TYR 616 ? C TYR 593 
849 1 Y 1 C THR 617 ? C THR 594 
850 1 Y 1 C GLN 618 ? C GLN 595 
851 1 Y 1 C GLU 619 ? C GLU 596 
852 1 Y 1 C LEU 620 ? C LEU 597 
853 1 Y 1 C ALA 621 ? C ALA 598 
854 1 Y 1 C PRO 622 ? C PRO 599 
855 1 Y 1 C LEU 623 ? C LEU 600 
856 1 Y 1 C VAL 624 ? C VAL 601 
857 1 Y 1 C ASN 625 ? C ASN 602 
858 1 Y 1 C PRO 626 ? C PRO 603 
859 1 Y 1 C LYS 627 ? C LYS 604 
860 1 Y 1 C VAL 628 ? C VAL 605 
861 1 Y 1 C GLU 629 ? C GLU 606 
862 1 Y 1 C ILE 630 ? C ILE 607 
863 1 Y 1 C PRO 631 ? C PRO 608 
864 1 Y 1 C TYR 632 ? C TYR 609 
865 1 Y 1 C SER 633 ? C SER 610 
866 1 Y 1 C THR 634 ? C THR 611 
867 1 Y 1 C PRO 635 ? C PRO 612 
868 1 Y 1 C ASN 636 ? C ASN 613 
869 1 Y 1 C SER 637 ? C SER 614 
870 1 Y 1 C PHE 638 ? C PHE 615 
871 1 Y 1 C VAL 639 ? C VAL 616 
872 1 Y 1 C LEU 640 ? C LEU 617 
873 1 Y 1 C ARG 641 ? C ARG 618 
874 1 Y 1 C TRP 642 ? C TRP 619 
875 1 Y 1 C PRO 643 ? C PRO 620 
876 1 Y 1 C ASP 644 ? C ASP 621 
877 1 Y 1 C TYR 645 ? C TYR 622 
878 1 Y 1 C ASP 646 ? C ASP 623 
879 1 Y 1 C SER 647 ? C SER 624 
880 1 Y 1 C ASP 648 ? C ASP 625 
881 1 Y 1 C PHE 649 ? C PHE 626 
882 1 Y 1 C GLN 650 ? C GLN 627 
883 1 Y 1 C ALA 651 ? C ALA 628 
884 1 Y 1 C GLY 652 ? C GLY 629 
885 1 Y 1 C PHE 653 ? C PHE 630 
886 1 Y 1 C ILE 654 ? C ILE 631 
887 1 Y 1 C LYS 655 ? C LYS 632 
888 1 Y 1 C GLY 656 ? C GLY 633 
889 1 Y 1 C TYR 657 ? C TYR 634 
890 1 Y 1 C LEU 658 ? C LEU 635 
891 1 Y 1 C VAL 659 ? C VAL 636 
892 1 Y 1 C TYR 660 ? C TYR 637 
893 1 Y 1 C VAL 661 ? C VAL 638 
894 1 Y 1 C LYS 662 ? C LYS 639 
895 1 Y 1 C SER 663 ? C SER 640 
896 1 Y 1 C LYS 664 ? C LYS 641 
897 1 Y 1 C GLU 665 ? C GLU 642 
898 1 Y 1 C MET 666 ? C MET 643 
899 1 Y 1 C GLN 667 ? C GLN 644 
900 1 Y 1 C CYS 668 ? C CYS 645 
901 1 Y 1 C ASN 669 ? C ASN 646 
902 1 Y 1 C GLN 670 ? C GLN 647 
903 1 Y 1 C PRO 671 ? C PRO 648 
904 1 Y 1 C TRP 672 ? C TRP 649 
905 1 Y 1 C GLU 673 ? C GLU 650 
906 1 Y 1 C ARG 674 ? C ARG 651 
907 1 Y 1 C THR 675 ? C THR 652 
908 1 Y 1 C LEU 676 ? C LEU 653 
909 1 Y 1 C LEU 677 ? C LEU 654 
910 1 Y 1 C PRO 678 ? C PRO 655 
911 1 Y 1 C ASP 679 ? C ASP 656 
912 1 Y 1 C ASN 680 ? C ASN 657 
913 1 Y 1 C SER 681 ? C SER 658 
914 1 Y 1 C VAL 682 ? C VAL 659 
915 1 Y 1 C LEU 683 ? C LEU 660 
916 1 Y 1 C CYS 684 ? C CYS 661 
917 1 Y 1 C LYS 685 ? C LYS 662 
918 1 Y 1 C TYR 686 ? C TYR 663 
919 1 Y 1 C ASP 687 ? C ASP 664 
920 1 Y 1 C ILE 688 ? C ILE 665 
921 1 Y 1 C ASN 689 ? C ASN 666 
922 1 Y 1 C GLY 690 ? C GLY 667 
923 1 Y 1 C SER 691 ? C SER 668 
924 1 Y 1 C GLU 692 ? C GLU 669 
925 1 Y 1 C THR 693 ? C THR 670 
926 1 Y 1 C LYS 694 ? C LYS 671 
927 1 Y 1 C THR 695 ? C THR 672 
928 1 Y 1 C LEU 696 ? C LEU 673 
929 1 Y 1 C THR 697 ? C THR 674 
930 1 Y 1 C VAL 698 ? C VAL 675 
931 1 Y 1 C GLU 699 ? C GLU 676 
932 1 Y 1 C ASN 700 ? C ASN 677 
933 1 Y 1 C LEU 701 ? C LEU 678 
934 1 Y 1 C GLN 702 ? C GLN 679 
935 1 Y 1 C PRO 703 ? C PRO 680 
936 1 Y 1 C GLU 704 ? C GLU 681 
937 1 Y 1 C SER 705 ? C SER 682 
938 1 Y 1 C LEU 706 ? C LEU 683 
939 1 Y 1 C TYR 707 ? C TYR 684 
940 1 Y 1 C GLU 708 ? C GLU 685 
941 1 Y 1 C PHE 709 ? C PHE 686 
942 1 Y 1 C PHE 710 ? C PHE 687 
943 1 Y 1 C VAL 711 ? C VAL 688 
944 1 Y 1 C THR 712 ? C THR 689 
945 1 Y 1 C PRO 713 ? C PRO 690 
946 1 Y 1 C TYR 714 ? C TYR 691 
947 1 Y 1 C THR 715 ? C THR 692 
948 1 Y 1 C SER 716 ? C SER 693 
949 1 Y 1 C ALA 717 ? C ALA 694 
950 1 Y 1 C GLY 718 ? C GLY 695 
951 1 Y 1 C PRO 719 ? C PRO 696 
952 1 Y 1 C GLY 720 ? C GLY 697 
953 1 Y 1 C PRO 721 ? C PRO 698 
954 1 Y 1 C ASN 722 ? C ASN 699 
955 1 Y 1 C GLU 723 ? C GLU 700 
956 1 Y 1 C THR 724 ? C THR 701 
957 1 Y 1 C PHE 725 ? C PHE 702 
958 1 Y 1 C THR 726 ? C THR 703 
959 1 Y 1 C LYS 727 ? C LYS 704 
960 1 Y 1 C VAL 728 ? C VAL 705 
961 1 Y 1 C THR 729 ? C THR 706 
962 1 Y 1 C THR 730 ? C THR 707 
963 1 Y 1 C PRO 731 ? C PRO 708 
964 1 Y 1 C ASP 732 ? C ASP 709 
965 1 Y 1 C ALA 733 ? C ALA 710 
966 1 Y 1 C ARG 734 ? C ARG 711 
967 1 Y 1 C SER 735 ? C SER 712 
968 1 Y 1 C HIS 736 ? C HIS 713 
969 1 Y 1 C MET 737 ? C MET 714 
970 1 Y 1 C LEU 738 ? C LEU 715 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
NAG C1   C N R 247 
NAG C2   C N R 248 
NAG C3   C N R 249 
NAG C4   C N S 250 
NAG C5   C N R 251 
NAG C6   C N N 252 
NAG C7   C N N 253 
NAG C8   C N N 254 
NAG N2   N N N 255 
NAG O1   O N N 256 
NAG O3   O N N 257 
NAG O4   O N N 258 
NAG O5   O N N 259 
NAG O6   O N N 260 
NAG O7   O N N 261 
NAG H1   H N N 262 
NAG H2   H N N 263 
NAG H3   H N N 264 
NAG H4   H N N 265 
NAG H5   H N N 266 
NAG H61  H N N 267 
NAG H62  H N N 268 
NAG H81  H N N 269 
NAG H82  H N N 270 
NAG H83  H N N 271 
NAG HN2  H N N 272 
NAG HO1  H N N 273 
NAG HO3  H N N 274 
NAG HO4  H N N 275 
NAG HO6  H N N 276 
PHE N    N N N 277 
PHE CA   C N S 278 
PHE C    C N N 279 
PHE O    O N N 280 
PHE CB   C N N 281 
PHE CG   C Y N 282 
PHE CD1  C Y N 283 
PHE CD2  C Y N 284 
PHE CE1  C Y N 285 
PHE CE2  C Y N 286 
PHE CZ   C Y N 287 
PHE OXT  O N N 288 
PHE H    H N N 289 
PHE H2   H N N 290 
PHE HA   H N N 291 
PHE HB2  H N N 292 
PHE HB3  H N N 293 
PHE HD1  H N N 294 
PHE HD2  H N N 295 
PHE HE1  H N N 296 
PHE HE2  H N N 297 
PHE HZ   H N N 298 
PHE HXT  H N N 299 
PRO N    N N N 300 
PRO CA   C N S 301 
PRO C    C N N 302 
PRO O    O N N 303 
PRO CB   C N N 304 
PRO CG   C N N 305 
PRO CD   C N N 306 
PRO OXT  O N N 307 
PRO H    H N N 308 
PRO HA   H N N 309 
PRO HB2  H N N 310 
PRO HB3  H N N 311 
PRO HG2  H N N 312 
PRO HG3  H N N 313 
PRO HD2  H N N 314 
PRO HD3  H N N 315 
PRO HXT  H N N 316 
SER N    N N N 317 
SER CA   C N S 318 
SER C    C N N 319 
SER O    O N N 320 
SER CB   C N N 321 
SER OG   O N N 322 
SER OXT  O N N 323 
SER H    H N N 324 
SER H2   H N N 325 
SER HA   H N N 326 
SER HB2  H N N 327 
SER HB3  H N N 328 
SER HG   H N N 329 
SER HXT  H N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
VAL N    N N N 399 
VAL CA   C N S 400 
VAL C    C N N 401 
VAL O    O N N 402 
VAL CB   C N N 403 
VAL CG1  C N N 404 
VAL CG2  C N N 405 
VAL OXT  O N N 406 
VAL H    H N N 407 
VAL H2   H N N 408 
VAL HA   H N N 409 
VAL HB   H N N 410 
VAL HG11 H N N 411 
VAL HG12 H N N 412 
VAL HG13 H N N 413 
VAL HG21 H N N 414 
VAL HG22 H N N 415 
VAL HG23 H N N 416 
VAL HXT  H N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
SER N   CA   sing N N 305 
SER N   H    sing N N 306 
SER N   H2   sing N N 307 
SER CA  C    sing N N 308 
SER CA  CB   sing N N 309 
SER CA  HA   sing N N 310 
SER C   O    doub N N 311 
SER C   OXT  sing N N 312 
SER CB  OG   sing N N 313 
SER CB  HB2  sing N N 314 
SER CB  HB3  sing N N 315 
SER OG  HG   sing N N 316 
SER OXT HXT  sing N N 317 
THR N   CA   sing N N 318 
THR N   H    sing N N 319 
THR N   H2   sing N N 320 
THR CA  C    sing N N 321 
THR CA  CB   sing N N 322 
THR CA  HA   sing N N 323 
THR C   O    doub N N 324 
THR C   OXT  sing N N 325 
THR CB  OG1  sing N N 326 
THR CB  CG2  sing N N 327 
THR CB  HB   sing N N 328 
THR OG1 HG1  sing N N 329 
THR CG2 HG21 sing N N 330 
THR CG2 HG22 sing N N 331 
THR CG2 HG23 sing N N 332 
THR OXT HXT  sing N N 333 
TRP N   CA   sing N N 334 
TRP N   H    sing N N 335 
TRP N   H2   sing N N 336 
TRP CA  C    sing N N 337 
TRP CA  CB   sing N N 338 
TRP CA  HA   sing N N 339 
TRP C   O    doub N N 340 
TRP C   OXT  sing N N 341 
TRP CB  CG   sing N N 342 
TRP CB  HB2  sing N N 343 
TRP CB  HB3  sing N N 344 
TRP CG  CD1  doub Y N 345 
TRP CG  CD2  sing Y N 346 
TRP CD1 NE1  sing Y N 347 
TRP CD1 HD1  sing N N 348 
TRP CD2 CE2  doub Y N 349 
TRP CD2 CE3  sing Y N 350 
TRP NE1 CE2  sing Y N 351 
TRP NE1 HE1  sing N N 352 
TRP CE2 CZ2  sing Y N 353 
TRP CE3 CZ3  doub Y N 354 
TRP CE3 HE3  sing N N 355 
TRP CZ2 CH2  doub Y N 356 
TRP CZ2 HZ2  sing N N 357 
TRP CZ3 CH2  sing Y N 358 
TRP CZ3 HZ3  sing N N 359 
TRP CH2 HH2  sing N N 360 
TRP OXT HXT  sing N N 361 
TYR N   CA   sing N N 362 
TYR N   H    sing N N 363 
TYR N   H2   sing N N 364 
TYR CA  C    sing N N 365 
TYR CA  CB   sing N N 366 
TYR CA  HA   sing N N 367 
TYR C   O    doub N N 368 
TYR C   OXT  sing N N 369 
TYR CB  CG   sing N N 370 
TYR CB  HB2  sing N N 371 
TYR CB  HB3  sing N N 372 
TYR CG  CD1  doub Y N 373 
TYR CG  CD2  sing Y N 374 
TYR CD1 CE1  sing Y N 375 
TYR CD1 HD1  sing N N 376 
TYR CD2 CE2  doub Y N 377 
TYR CD2 HD2  sing N N 378 
TYR CE1 CZ   doub Y N 379 
TYR CE1 HE1  sing N N 380 
TYR CE2 CZ   sing Y N 381 
TYR CE2 HE2  sing N N 382 
TYR CZ  OH   sing N N 383 
TYR OH  HH   sing N N 384 
TYR OXT HXT  sing N N 385 
VAL N   CA   sing N N 386 
VAL N   H    sing N N 387 
VAL N   H2   sing N N 388 
VAL CA  C    sing N N 389 
VAL CA  CB   sing N N 390 
VAL CA  HA   sing N N 391 
VAL C   O    doub N N 392 
VAL C   OXT  sing N N 393 
VAL CB  CG1  sing N N 394 
VAL CB  CG2  sing N N 395 
VAL CB  HB   sing N N 396 
VAL CG1 HG11 sing N N 397 
VAL CG1 HG12 sing N N 398 
VAL CG1 HG13 sing N N 399 
VAL CG2 HG21 sing N N 400 
VAL CG2 HG22 sing N N 401 
VAL CG2 HG23 sing N N 402 
VAL OXT HXT  sing N N 403 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-11-22 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8V2C 
_em_admin.last_update        2024-11-20 
_em_admin.map_release_date   2024-11-20 
_em_admin.title              'Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         40 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
4 NAG 1 n 
4 NAG 2 n 
# 
_atom_sites.entry_id                    8V2C 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 1   ? 121.324 153.742 152.997 1.00 65.43  ? 24  ALA A N   1 
ATOM   2    C CA  . ALA A 1 1   ? 120.163 152.878 153.174 1.00 65.43  ? 24  ALA A CA  1 
ATOM   3    C C   . ALA A 1 1   ? 120.087 151.846 152.051 1.00 65.43  ? 24  ALA A C   1 
ATOM   4    O O   . ALA A 1 1   ? 120.535 150.711 152.210 1.00 65.43  ? 24  ALA A O   1 
ATOM   5    C CB  . ALA A 1 1   ? 118.888 153.708 153.229 1.00 65.43  ? 24  ALA A CB  1 
ATOM   6    N N   . ASN A 1 2   ? 119.522 152.251 150.914 1.00 70.40  ? 25  ASN A N   1 
ATOM   7    C CA  . ASN A 1 2   ? 119.397 151.400 149.735 1.00 70.40  ? 25  ASN A CA  1 
ATOM   8    C C   . ASN A 1 2   ? 120.624 151.484 148.825 1.00 70.40  ? 25  ASN A C   1 
ATOM   9    O O   . ASN A 1 2   ? 120.581 151.005 147.687 1.00 70.40  ? 25  ASN A O   1 
ATOM   10   C CB  . ASN A 1 2   ? 118.125 151.784 148.965 1.00 70.40  ? 25  ASN A CB  1 
ATOM   11   C CG  . ASN A 1 2   ? 117.721 150.757 147.914 1.00 70.40  ? 25  ASN A CG  1 
ATOM   12   O OD1 . ASN A 1 2   ? 118.281 149.662 147.836 1.00 70.40  ? 25  ASN A OD1 1 
ATOM   13   N ND2 . ASN A 1 2   ? 116.731 151.110 147.101 1.00 70.40  ? 25  ASN A ND2 1 
ATOM   14   N N   . ARG A 1 3   ? 121.721 152.083 149.294 1.00 61.17  ? 26  ARG A N   1 
ATOM   15   C CA  . ARG A 1 3   ? 122.937 152.207 148.498 1.00 61.17  ? 26  ARG A CA  1 
ATOM   16   C C   . ARG A 1 3   ? 123.950 151.110 148.804 1.00 61.17  ? 26  ARG A C   1 
ATOM   17   O O   . ARG A 1 3   ? 125.162 151.338 148.688 1.00 61.17  ? 26  ARG A O   1 
ATOM   18   C CB  . ARG A 1 3   ? 123.558 153.589 148.701 1.00 61.17  ? 26  ARG A CB  1 
ATOM   19   C CG  . ARG A 1 3   ? 122.568 154.735 148.561 1.00 61.17  ? 26  ARG A CG  1 
ATOM   20   C CD  . ARG A 1 3   ? 123.188 155.917 147.836 1.00 61.17  ? 26  ARG A CD  1 
ATOM   21   N NE  . ARG A 1 3   ? 123.400 155.627 146.422 1.00 61.17  ? 26  ARG A NE  1 
ATOM   22   C CZ  . ARG A 1 3   ? 123.858 156.509 145.540 1.00 61.17  ? 26  ARG A CZ  1 
ATOM   23   N NH1 . ARG A 1 3   ? 124.019 156.159 144.272 1.00 61.17  ? 26  ARG A NH1 1 
ATOM   24   N NH2 . ARG A 1 3   ? 124.154 157.741 145.926 1.00 61.17  ? 26  ARG A NH2 1 
ATOM   25   N N   . GLY A 1 4   ? 123.485 149.929 149.189 1.00 61.70  ? 27  GLY A N   1 
ATOM   26   C CA  . GLY A 1 4   ? 124.378 148.821 149.472 1.00 61.70  ? 27  GLY A CA  1 
ATOM   27   C C   . GLY A 1 4   ? 123.586 147.622 149.936 1.00 61.70  ? 27  GLY A C   1 
ATOM   28   O O   . GLY A 1 4   ? 122.367 147.689 150.131 1.00 61.70  ? 27  GLY A O   1 
ATOM   29   N N   . CYS A 1 5   ? 124.305 146.511 150.113 1.00 62.53  ? 28  CYS A N   1 
ATOM   30   C CA  . CYS A 1 5   ? 123.737 145.262 150.621 1.00 62.53  ? 28  CYS A CA  1 
ATOM   31   C C   . CYS A 1 5   ? 122.595 144.777 149.721 1.00 62.53  ? 28  CYS A C   1 
ATOM   32   O O   . CYS A 1 5   ? 121.423 144.749 150.102 1.00 62.53  ? 28  CYS A O   1 
ATOM   33   C CB  . CYS A 1 5   ? 123.269 145.430 152.071 1.00 62.53  ? 28  CYS A CB  1 
ATOM   34   S SG  . CYS A 1 5   ? 124.608 145.490 153.276 1.00 62.53  ? 28  CYS A SG  1 
ATOM   35   N N   . SER A 1 6   ? 122.982 144.406 148.502 1.00 62.00  ? 29  SER A N   1 
ATOM   36   C CA  . SER A 1 6   ? 122.031 143.979 147.486 1.00 62.00  ? 29  SER A CA  1 
ATOM   37   C C   . SER A 1 6   ? 121.215 142.777 147.968 1.00 62.00  ? 29  SER A C   1 
ATOM   38   O O   . SER A 1 6   ? 121.527 142.131 148.971 1.00 62.00  ? 29  SER A O   1 
ATOM   39   C CB  . SER A 1 6   ? 122.760 143.636 146.188 1.00 62.00  ? 29  SER A CB  1 
ATOM   40   O OG  . SER A 1 6   ? 123.058 144.806 145.446 1.00 62.00  ? 29  SER A OG  1 
ATOM   41   N N   . ASN A 1 7   ? 120.155 142.474 147.213 1.00 59.24  ? 30  ASN A N   1 
ATOM   42   C CA  . ASN A 1 7   ? 119.180 141.469 147.621 1.00 59.24  ? 30  ASN A CA  1 
ATOM   43   C C   . ASN A 1 7   ? 119.749 140.056 147.674 1.00 59.24  ? 30  ASN A C   1 
ATOM   44   O O   . ASN A 1 7   ? 119.017 139.131 148.044 1.00 59.24  ? 30  ASN A O   1 
ATOM   45   C CB  . ASN A 1 7   ? 117.977 141.502 146.676 1.00 59.24  ? 30  ASN A CB  1 
ATOM   46   C CG  . ASN A 1 7   ? 117.069 142.687 146.934 1.00 59.24  ? 30  ASN A CG  1 
ATOM   47   O OD1 . ASN A 1 7   ? 117.532 143.818 147.077 1.00 59.24  ? 30  ASN A OD1 1 
ATOM   48   N ND2 . ASN A 1 7   ? 115.766 142.435 146.994 1.00 59.24  ? 30  ASN A ND2 1 
ATOM   49   N N   . SER A 1 8   ? 121.015 139.860 147.314 1.00 56.39  ? 31  SER A N   1 
ATOM   50   C CA  . SER A 1 8   ? 121.617 138.537 147.393 1.00 56.39  ? 31  SER A CA  1 
ATOM   51   C C   . SER A 1 8   ? 121.711 138.089 148.846 1.00 56.39  ? 31  SER A C   1 
ATOM   52   O O   . SER A 1 8   ? 122.241 138.810 149.697 1.00 56.39  ? 31  SER A O   1 
ATOM   53   C CB  . SER A 1 8   ? 123.002 138.544 146.749 1.00 56.39  ? 31  SER A CB  1 
ATOM   54   O OG  . SER A 1 8   ? 123.995 138.928 147.684 1.00 56.39  ? 31  SER A OG  1 
ATOM   55   N N   . SER A 1 9   ? 121.193 136.895 149.130 1.00 49.44  ? 32  SER A N   1 
ATOM   56   C CA  . SER A 1 9   ? 121.193 136.340 150.478 1.00 49.44  ? 32  SER A CA  1 
ATOM   57   C C   . SER A 1 9   ? 122.273 135.288 150.687 1.00 49.44  ? 32  SER A C   1 
ATOM   58   O O   . SER A 1 9   ? 122.889 135.245 151.757 1.00 49.44  ? 32  SER A O   1 
ATOM   59   C CB  . SER A 1 9   ? 119.824 135.733 150.799 1.00 49.44  ? 32  SER A CB  1 
ATOM   60   O OG  . SER A 1 9   ? 119.920 134.787 151.848 1.00 49.44  ? 32  SER A OG  1 
ATOM   61   N N   . SER A 1 10  ? 122.516 134.437 149.688 1.00 47.49  ? 33  SER A N   1 
ATOM   62   C CA  . SER A 1 10  ? 123.557 133.424 149.821 1.00 47.49  ? 33  SER A CA  1 
ATOM   63   C C   . SER A 1 10  ? 124.935 134.063 149.929 1.00 47.49  ? 33  SER A C   1 
ATOM   64   O O   . SER A 1 10  ? 125.780 133.607 150.710 1.00 47.49  ? 33  SER A O   1 
ATOM   65   C CB  . SER A 1 10  ? 123.502 132.459 148.637 1.00 47.49  ? 33  SER A CB  1 
ATOM   66   O OG  . SER A 1 10  ? 122.168 132.072 148.359 1.00 47.49  ? 33  SER A OG  1 
ATOM   67   N N   . GLN A 1 11  ? 125.180 135.124 149.157 1.00 47.83  ? 34  GLN A N   1 
ATOM   68   C CA  . GLN A 1 11  ? 126.453 135.830 149.256 1.00 47.83  ? 34  GLN A CA  1 
ATOM   69   C C   . GLN A 1 11  ? 126.627 136.455 150.634 1.00 47.83  ? 34  GLN A C   1 
ATOM   70   O O   . GLN A 1 11  ? 127.720 136.415 151.210 1.00 47.83  ? 34  GLN A O   1 
ATOM   71   C CB  . GLN A 1 11  ? 126.548 136.897 148.166 1.00 47.83  ? 34  GLN A CB  1 
ATOM   72   C CG  . GLN A 1 11  ? 127.835 137.702 148.195 1.00 47.83  ? 34  GLN A CG  1 
ATOM   73   C CD  . GLN A 1 11  ? 127.851 138.814 147.165 1.00 47.83  ? 34  GLN A CD  1 
ATOM   74   O OE1 . GLN A 1 11  ? 126.863 139.044 146.469 1.00 47.83  ? 34  GLN A OE1 1 
ATOM   75   N NE2 . GLN A 1 11  ? 128.977 139.510 147.062 1.00 47.83  ? 34  GLN A NE2 1 
ATOM   76   N N   . LEU A 1 12  ? 125.554 137.028 151.182 1.00 45.51  ? 35  LEU A N   1 
ATOM   77   C CA  . LEU A 1 12  ? 125.630 137.621 152.513 1.00 45.51  ? 35  LEU A CA  1 
ATOM   78   C C   . LEU A 1 12  ? 125.901 136.559 153.572 1.00 45.51  ? 35  LEU A C   1 
ATOM   79   O O   . LEU A 1 12  ? 126.699 136.776 154.492 1.00 45.51  ? 35  LEU A O   1 
ATOM   80   C CB  . LEU A 1 12  ? 124.335 138.372 152.820 1.00 45.51  ? 35  LEU A CB  1 
ATOM   81   C CG  . LEU A 1 12  ? 124.431 139.559 153.777 1.00 45.51  ? 35  LEU A CG  1 
ATOM   82   C CD1 . LEU A 1 12  ? 125.440 140.571 153.263 1.00 45.51  ? 35  LEU A CD1 1 
ATOM   83   C CD2 . LEU A 1 12  ? 123.069 140.202 153.952 1.00 45.51  ? 35  LEU A CD2 1 
ATOM   84   N N   . LEU A 1 13  ? 125.254 135.398 153.452 1.00 44.45  ? 36  LEU A N   1 
ATOM   85   C CA  . LEU A 1 13  ? 125.489 134.318 154.405 1.00 44.45  ? 36  LEU A CA  1 
ATOM   86   C C   . LEU A 1 13  ? 126.921 133.804 154.313 1.00 44.45  ? 36  LEU A C   1 
ATOM   87   O O   . LEU A 1 13  ? 127.556 133.524 155.338 1.00 44.45  ? 36  LEU A O   1 
ATOM   88   C CB  . LEU A 1 13  ? 124.494 133.185 154.166 1.00 44.45  ? 36  LEU A CB  1 
ATOM   89   C CG  . LEU A 1 13  ? 124.526 132.028 155.164 1.00 44.45  ? 36  LEU A CG  1 
ATOM   90   C CD1 . LEU A 1 13  ? 124.234 132.531 156.567 1.00 44.45  ? 36  LEU A CD1 1 
ATOM   91   C CD2 . LEU A 1 13  ? 123.534 130.951 154.761 1.00 44.45  ? 36  LEU A CD2 1 
ATOM   92   N N   . SER A 1 14  ? 127.449 133.677 153.093 1.00 43.23  ? 37  SER A N   1 
ATOM   93   C CA  . SER A 1 14  ? 128.830 133.236 152.929 1.00 43.23  ? 37  SER A CA  1 
ATOM   94   C C   . SER A 1 14  ? 129.805 134.251 153.512 1.00 43.23  ? 37  SER A C   1 
ATOM   95   O O   . SER A 1 14  ? 130.792 133.876 154.157 1.00 43.23  ? 37  SER A O   1 
ATOM   96   C CB  . SER A 1 14  ? 129.130 132.988 151.452 1.00 43.23  ? 37  SER A CB  1 
ATOM   97   O OG  . SER A 1 14  ? 128.122 132.192 150.856 1.00 43.23  ? 37  SER A OG  1 
ATOM   98   N N   . GLN A 1 15  ? 129.543 135.543 153.299 1.00 41.02  ? 38  GLN A N   1 
ATOM   99   C CA  . GLN A 1 15  ? 130.393 136.575 153.883 1.00 41.02  ? 38  GLN A CA  1 
ATOM   100  C C   . GLN A 1 15  ? 130.355 136.521 155.404 1.00 41.02  ? 38  GLN A C   1 
ATOM   101  O O   . GLN A 1 15  ? 131.392 136.656 156.063 1.00 41.02  ? 38  GLN A O   1 
ATOM   102  C CB  . GLN A 1 15  ? 129.962 137.955 153.387 1.00 41.02  ? 38  GLN A CB  1 
ATOM   103  C CG  . GLN A 1 15  ? 130.309 138.236 151.938 1.00 41.02  ? 38  GLN A CG  1 
ATOM   104  C CD  . GLN A 1 15  ? 129.677 139.514 151.428 1.00 41.02  ? 38  GLN A CD  1 
ATOM   105  O OE1 . GLN A 1 15  ? 128.709 140.012 152.001 1.00 41.02  ? 38  GLN A OE1 1 
ATOM   106  N NE2 . GLN A 1 15  ? 130.224 140.054 150.347 1.00 41.02  ? 38  GLN A NE2 1 
ATOM   107  N N   . LEU A 1 16  ? 129.167 136.319 155.979 1.00 41.82  ? 39  LEU A N   1 
ATOM   108  C CA  . LEU A 1 16  ? 129.055 136.223 157.431 1.00 41.82  ? 39  LEU A CA  1 
ATOM   109  C C   . LEU A 1 16  ? 129.825 135.023 157.967 1.00 41.82  ? 39  LEU A C   1 
ATOM   110  O O   . LEU A 1 16  ? 130.544 135.135 158.968 1.00 41.82  ? 39  LEU A O   1 
ATOM   111  C CB  . LEU A 1 16  ? 127.585 136.143 157.840 1.00 41.82  ? 39  LEU A CB  1 
ATOM   112  C CG  . LEU A 1 16  ? 126.875 137.477 158.069 1.00 41.82  ? 39  LEU A CG  1 
ATOM   113  C CD1 . LEU A 1 16  ? 125.384 137.264 158.261 1.00 41.82  ? 39  LEU A CD1 1 
ATOM   114  C CD2 . LEU A 1 16  ? 127.472 138.194 159.267 1.00 41.82  ? 39  LEU A CD2 1 
ATOM   115  N N   . GLN A 1 17  ? 129.689 133.867 157.314 1.00 42.46  ? 40  GLN A N   1 
ATOM   116  C CA  . GLN A 1 17  ? 130.404 132.677 157.766 1.00 42.46  ? 40  GLN A CA  1 
ATOM   117  C C   . GLN A 1 17  ? 131.913 132.864 157.663 1.00 42.46  ? 40  GLN A C   1 
ATOM   118  O O   . GLN A 1 17  ? 132.659 132.470 158.569 1.00 42.46  ? 40  GLN A O   1 
ATOM   119  C CB  . GLN A 1 17  ? 129.955 131.458 156.963 1.00 42.46  ? 40  GLN A CB  1 
ATOM   120  C CG  . GLN A 1 17  ? 128.521 131.039 157.229 1.00 42.46  ? 40  GLN A CG  1 
ATOM   121  C CD  . GLN A 1 17  ? 128.119 129.808 156.444 1.00 42.46  ? 40  GLN A CD  1 
ATOM   122  O OE1 . GLN A 1 17  ? 127.666 129.904 155.305 1.00 42.46  ? 40  GLN A OE1 1 
ATOM   123  N NE2 . GLN A 1 17  ? 128.288 128.640 157.051 1.00 42.46  ? 40  GLN A NE2 1 
ATOM   124  N N   . ASN A 1 18  ? 132.383 133.473 156.571 1.00 40.85  ? 41  ASN A N   1 
ATOM   125  C CA  . ASN A 1 18  ? 133.817 133.692 156.415 1.00 40.85  ? 41  ASN A CA  1 
ATOM   126  C C   . ASN A 1 18  ? 134.342 134.677 157.451 1.00 40.85  ? 41  ASN A C   1 
ATOM   127  O O   . ASN A 1 18  ? 135.426 134.475 158.012 1.00 40.85  ? 41  ASN A O   1 
ATOM   128  C CB  . ASN A 1 18  ? 134.123 134.182 155.000 1.00 40.85  ? 41  ASN A CB  1 
ATOM   129  C CG  . ASN A 1 18  ? 133.900 133.110 153.953 1.00 40.85  ? 41  ASN A CG  1 
ATOM   130  O OD1 . ASN A 1 18  ? 133.265 132.089 154.217 1.00 40.85  ? 41  ASN A OD1 1 
ATOM   131  N ND2 . ASN A 1 18  ? 134.422 133.337 152.754 1.00 40.85  ? 41  ASN A ND2 1 
ATOM   132  N N   . GLN A 1 19  ? 133.587 135.744 157.728 1.00 38.83  ? 42  GLN A N   1 
ATOM   133  C CA  . GLN A 1 19  ? 134.013 136.702 158.742 1.00 38.83  ? 42  GLN A CA  1 
ATOM   134  C C   . GLN A 1 19  ? 134.049 136.062 160.123 1.00 38.83  ? 42  GLN A C   1 
ATOM   135  O O   . GLN A 1 19  ? 134.960 136.329 160.915 1.00 38.83  ? 42  GLN A O   1 
ATOM   136  C CB  . GLN A 1 19  ? 133.090 137.919 158.739 1.00 38.83  ? 42  GLN A CB  1 
ATOM   137  C CG  . GLN A 1 19  ? 133.368 138.901 157.617 1.00 38.83  ? 42  GLN A CG  1 
ATOM   138  C CD  . GLN A 1 19  ? 132.491 140.132 157.694 1.00 38.83  ? 42  GLN A CD  1 
ATOM   139  O OE1 . GLN A 1 19  ? 131.284 140.036 157.913 1.00 38.83  ? 42  GLN A OE1 1 
ATOM   140  N NE2 . GLN A 1 19  ? 133.096 141.300 157.518 1.00 38.83  ? 42  GLN A NE2 1 
ATOM   141  N N   . ALA A 1 20  ? 133.070 135.208 160.429 1.00 38.70  ? 43  ALA A N   1 
ATOM   142  C CA  . ALA A 1 20  ? 133.073 134.524 161.718 1.00 38.70  ? 43  ALA A CA  1 
ATOM   143  C C   . ALA A 1 20  ? 134.258 133.575 161.838 1.00 38.70  ? 43  ALA A C   1 
ATOM   144  O O   . ALA A 1 20  ? 134.914 133.522 162.885 1.00 38.70  ? 43  ALA A O   1 
ATOM   145  C CB  . ALA A 1 20  ? 131.758 133.773 161.915 1.00 38.70  ? 43  ALA A CB  1 
ATOM   146  N N   . ASN A 1 21  ? 134.553 132.819 160.775 1.00 42.87  ? 44  ASN A N   1 
ATOM   147  C CA  . ASN A 1 21  ? 135.702 131.919 160.808 1.00 42.87  ? 44  ASN A CA  1 
ATOM   148  C C   . ASN A 1 21  ? 137.016 132.683 160.914 1.00 42.87  ? 44  ASN A C   1 
ATOM   149  O O   . ASN A 1 21  ? 137.967 132.193 161.534 1.00 42.87  ? 44  ASN A O   1 
ATOM   150  C CB  . ASN A 1 21  ? 135.712 131.027 159.567 1.00 42.87  ? 44  ASN A CB  1 
ATOM   151  C CG  . ASN A 1 21  ? 134.601 129.996 159.580 1.00 42.87  ? 44  ASN A CG  1 
ATOM   152  O OD1 . ASN A 1 21  ? 133.656 130.094 160.361 1.00 42.87  ? 44  ASN A OD1 1 
ATOM   153  N ND2 . ASN A 1 21  ? 134.709 129.000 158.708 1.00 42.87  ? 44  ASN A ND2 1 
ATOM   154  N N   . LEU A 1 22  ? 137.091 133.875 160.319 1.00 43.42  ? 45  LEU A N   1 
ATOM   155  C CA  . LEU A 1 22  ? 138.319 134.660 160.395 1.00 43.42  ? 45  LEU A CA  1 
ATOM   156  C C   . LEU A 1 22  ? 138.486 135.300 161.768 1.00 43.42  ? 45  LEU A C   1 
ATOM   157  O O   . LEU A 1 22  ? 139.607 135.403 162.278 1.00 43.42  ? 45  LEU A O   1 
ATOM   158  C CB  . LEU A 1 22  ? 138.322 135.726 159.298 1.00 43.42  ? 45  LEU A CB  1 
ATOM   159  C CG  . LEU A 1 22  ? 139.499 136.701 159.258 1.00 43.42  ? 45  LEU A CG  1 
ATOM   160  C CD1 . LEU A 1 22  ? 139.993 136.876 157.833 1.00 43.42  ? 45  LEU A CD1 1 
ATOM   161  C CD2 . LEU A 1 22  ? 139.103 138.043 159.850 1.00 43.42  ? 45  LEU A CD2 1 
ATOM   162  N N   . THR A 1 23  ? 137.384 135.735 162.382 1.00 41.01  ? 46  THR A N   1 
ATOM   163  C CA  . THR A 1 23  ? 137.469 136.410 163.672 1.00 41.01  ? 46  THR A CA  1 
ATOM   164  C C   . THR A 1 23  ? 137.668 135.424 164.816 1.00 41.01  ? 46  THR A C   1 
ATOM   165  O O   . THR A 1 23  ? 138.415 135.708 165.759 1.00 41.01  ? 46  THR A O   1 
ATOM   166  C CB  . THR A 1 23  ? 136.214 137.250 163.906 1.00 41.01  ? 46  THR A CB  1 
ATOM   167  O OG1 . THR A 1 23  ? 136.021 138.141 162.800 1.00 41.01  ? 46  THR A OG1 1 
ATOM   168  C CG2 . THR A 1 23  ? 136.350 138.063 165.176 1.00 41.01  ? 46  THR A CG2 1 
ATOM   169  N N   . GLY A 1 24  ? 137.022 134.262 164.754 1.00 41.42  ? 47  GLY A N   1 
ATOM   170  C CA  . GLY A 1 24  ? 137.159 133.279 165.810 1.00 41.42  ? 47  GLY A CA  1 
ATOM   171  C C   . GLY A 1 24  ? 138.489 132.556 165.774 1.00 41.42  ? 47  GLY A C   1 
ATOM   172  O O   . GLY A 1 24  ? 138.539 131.340 165.565 1.00 41.42  ? 47  GLY A O   1 
ATOM   173  N N   . ASN A 1 25  ? 139.575 133.296 165.984 1.00 42.51  ? 48  ASN A N   1 
ATOM   174  C CA  . ASN A 1 25  ? 140.919 132.736 165.938 1.00 42.51  ? 48  ASN A CA  1 
ATOM   175  C C   . ASN A 1 25  ? 141.749 133.384 167.034 1.00 42.51  ? 48  ASN A C   1 
ATOM   176  O O   . ASN A 1 25  ? 141.819 134.614 167.115 1.00 42.51  ? 48  ASN A O   1 
ATOM   177  C CB  . ASN A 1 25  ? 141.566 132.963 164.567 1.00 42.51  ? 48  ASN A CB  1 
ATOM   178  C CG  . ASN A 1 25  ? 142.877 132.220 164.409 1.00 42.51  ? 48  ASN A CG  1 
ATOM   179  O OD1 . ASN A 1 25  ? 143.157 131.269 165.139 1.00 42.51  ? 48  ASN A OD1 1 
ATOM   180  N ND2 . ASN A 1 25  ? 143.688 132.649 163.449 1.00 42.51  ? 48  ASN A ND2 1 
ATOM   181  N N   . THR A 1 26  ? 142.374 132.554 167.873 1.00 41.96  ? 49  THR A N   1 
ATOM   182  C CA  . THR A 1 26  ? 143.134 133.065 169.008 1.00 41.96  ? 49  THR A CA  1 
ATOM   183  C C   . THR A 1 26  ? 144.334 133.899 168.577 1.00 41.96  ? 49  THR A C   1 
ATOM   184  O O   . THR A 1 26  ? 144.725 134.821 169.300 1.00 41.96  ? 49  THR A O   1 
ATOM   185  C CB  . THR A 1 26  ? 143.592 131.901 169.892 1.00 41.96  ? 49  THR A CB  1 
ATOM   186  O OG1 . THR A 1 26  ? 142.470 131.063 170.194 1.00 41.96  ? 49  THR A OG1 1 
ATOM   187  C CG2 . THR A 1 26  ? 144.187 132.410 171.194 1.00 41.96  ? 49  THR A CG2 1 
ATOM   188  N N   . GLU A 1 27  ? 144.914 133.613 167.411 1.00 46.02  ? 50  GLU A N   1 
ATOM   189  C CA  . GLU A 1 27  ? 146.068 134.364 166.934 1.00 46.02  ? 50  GLU A CA  1 
ATOM   190  C C   . GLU A 1 27  ? 145.705 135.765 166.461 1.00 46.02  ? 50  GLU A C   1 
ATOM   191  O O   . GLU A 1 27  ? 146.607 136.542 166.130 1.00 46.02  ? 50  GLU A O   1 
ATOM   192  C CB  . GLU A 1 27  ? 146.756 133.588 165.807 1.00 46.02  ? 50  GLU A CB  1 
ATOM   193  C CG  . GLU A 1 27  ? 148.277 133.679 165.800 1.00 46.02  ? 50  GLU A CG  1 
ATOM   194  C CD  . GLU A 1 27  ? 148.797 134.895 165.057 1.00 46.02  ? 50  GLU A CD  1 
ATOM   195  O OE1 . GLU A 1 27  ? 149.849 135.433 165.459 1.00 46.02  ? 50  GLU A OE1 1 
ATOM   196  O OE2 . GLU A 1 27  ? 148.156 135.310 164.069 1.00 46.02  ? 50  GLU A OE2 1 
ATOM   197  N N   . SER A 1 28  ? 144.419 136.112 166.428 1.00 41.93  ? 51  SER A N   1 
ATOM   198  C CA  . SER A 1 28  ? 144.008 137.416 165.920 1.00 41.93  ? 51  SER A CA  1 
ATOM   199  C C   . SER A 1 28  ? 144.321 138.531 166.913 1.00 41.93  ? 51  SER A C   1 
ATOM   200  O O   . SER A 1 28  ? 145.050 139.475 166.593 1.00 41.93  ? 51  SER A O   1 
ATOM   201  C CB  . SER A 1 28  ? 142.515 137.402 165.584 1.00 41.93  ? 51  SER A CB  1 
ATOM   202  O OG  . SER A 1 28  ? 142.079 138.679 165.151 1.00 41.93  ? 51  SER A OG  1 
ATOM   203  N N   . LEU A 1 29  ? 143.777 138.439 168.127 1.00 40.46  ? 52  LEU A N   1 
ATOM   204  C CA  . LEU A 1 29  ? 143.893 139.534 169.082 1.00 40.46  ? 52  LEU A CA  1 
ATOM   205  C C   . LEU A 1 29  ? 144.408 139.073 170.441 1.00 40.46  ? 52  LEU A C   1 
ATOM   206  O O   . LEU A 1 29  ? 145.069 139.840 171.148 1.00 40.46  ? 52  LEU A O   1 
ATOM   207  C CB  . LEU A 1 29  ? 142.540 140.229 169.242 1.00 40.46  ? 52  LEU A CB  1 
ATOM   208  C CG  . LEU A 1 29  ? 142.519 141.555 170.004 1.00 40.46  ? 52  LEU A CG  1 
ATOM   209  C CD1 . LEU A 1 29  ? 143.495 142.540 169.387 1.00 40.46  ? 52  LEU A CD1 1 
ATOM   210  C CD2 . LEU A 1 29  ? 141.116 142.132 170.017 1.00 40.46  ? 52  LEU A CD2 1 
ATOM   211  N N   . LEU A 1 30  ? 144.116 137.828 170.820 1.00 38.90  ? 53  LEU A N   1 
ATOM   212  C CA  . LEU A 1 30  ? 144.478 137.365 172.157 1.00 38.90  ? 53  LEU A CA  1 
ATOM   213  C C   . LEU A 1 30  ? 145.970 137.074 172.260 1.00 38.90  ? 53  LEU A C   1 
ATOM   214  O O   . LEU A 1 30  ? 146.627 137.486 173.224 1.00 38.90  ? 53  LEU A O   1 
ATOM   215  C CB  . LEU A 1 30  ? 143.662 136.127 172.525 1.00 38.90  ? 53  LEU A CB  1 
ATOM   216  C CG  . LEU A 1 30  ? 143.977 135.516 173.892 1.00 38.90  ? 53  LEU A CG  1 
ATOM   217  C CD1 . LEU A 1 30  ? 143.817 136.552 174.991 1.00 38.90  ? 53  LEU A CD1 1 
ATOM   218  C CD2 . LEU A 1 30  ? 143.093 134.310 174.160 1.00 38.90  ? 53  LEU A CD2 1 
ATOM   219  N N   . GLU A 1 31  ? 146.522 136.357 171.283 1.00 43.65  ? 54  GLU A N   1 
ATOM   220  C CA  . GLU A 1 31  ? 147.934 135.993 171.350 1.00 43.65  ? 54  GLU A CA  1 
ATOM   221  C C   . GLU A 1 31  ? 148.874 137.191 171.256 1.00 43.65  ? 54  GLU A C   1 
ATOM   222  O O   . GLU A 1 31  ? 149.853 137.227 172.023 1.00 43.65  ? 54  GLU A O   1 
ATOM   223  C CB  . GLU A 1 31  ? 148.255 134.957 170.264 1.00 43.65  ? 54  GLU A CB  1 
ATOM   224  C CG  . GLU A 1 31  ? 147.606 133.598 170.485 1.00 43.65  ? 54  GLU A CG  1 
ATOM   225  C CD  . GLU A 1 31  ? 148.239 132.816 171.622 1.00 43.65  ? 54  GLU A CD  1 
ATOM   226  O OE1 . GLU A 1 31  ? 147.999 133.164 172.797 1.00 43.65  ? 54  GLU A OE1 1 
ATOM   227  O OE2 . GLU A 1 31  ? 148.978 131.851 171.338 1.00 43.65  ? 54  GLU A OE2 1 
ATOM   228  N N   . PRO A 1 32  ? 148.672 138.172 170.364 1.00 41.85  ? 55  PRO A N   1 
ATOM   229  C CA  . PRO A 1 32  ? 149.542 139.360 170.409 1.00 41.85  ? 55  PRO A CA  1 
ATOM   230  C C   . PRO A 1 32  ? 149.437 140.125 171.715 1.00 41.85  ? 55  PRO A C   1 
ATOM   231  O O   . PRO A 1 32  ? 150.451 140.620 172.222 1.00 41.85  ? 55  PRO A O   1 
ATOM   232  C CB  . PRO A 1 32  ? 149.055 140.194 169.216 1.00 41.85  ? 55  PRO A CB  1 
ATOM   233  C CG  . PRO A 1 32  ? 148.434 139.209 168.299 1.00 41.85  ? 55  PRO A CG  1 
ATOM   234  C CD  . PRO A 1 32  ? 147.781 138.203 169.190 1.00 41.85  ? 55  PRO A CD  1 
ATOM   235  N N   . TYR A 1 33  ? 148.232 140.234 172.278 1.00 40.24  ? 56  TYR A N   1 
ATOM   236  C CA  . TYR A 1 33  ? 148.075 140.924 173.554 1.00 40.24  ? 56  TYR A CA  1 
ATOM   237  C C   . TYR A 1 33  ? 148.794 140.182 174.674 1.00 40.24  ? 56  TYR A C   1 
ATOM   238  O O   . TYR A 1 33  ? 149.373 140.810 175.567 1.00 40.24  ? 56  TYR A O   1 
ATOM   239  C CB  . TYR A 1 33  ? 146.593 141.088 173.884 1.00 40.24  ? 56  TYR A CB  1 
ATOM   240  C CG  . TYR A 1 33  ? 146.333 141.766 175.209 1.00 40.24  ? 56  TYR A CG  1 
ATOM   241  C CD1 . TYR A 1 33  ? 146.033 141.024 176.343 1.00 40.24  ? 56  TYR A CD1 1 
ATOM   242  C CD2 . TYR A 1 33  ? 146.386 143.147 175.327 1.00 40.24  ? 56  TYR A CD2 1 
ATOM   243  C CE1 . TYR A 1 33  ? 145.795 141.639 177.556 1.00 40.24  ? 56  TYR A CE1 1 
ATOM   244  C CE2 . TYR A 1 33  ? 146.149 143.771 176.536 1.00 40.24  ? 56  TYR A CE2 1 
ATOM   245  C CZ  . TYR A 1 33  ? 145.854 143.011 177.646 1.00 40.24  ? 56  TYR A CZ  1 
ATOM   246  O OH  . TYR A 1 33  ? 145.618 143.628 178.853 1.00 40.24  ? 56  TYR A OH  1 
ATOM   247  N N   . ILE A 1 34  ? 148.768 138.849 174.645 1.00 42.10  ? 57  ILE A N   1 
ATOM   248  C CA  . ILE A 1 34  ? 149.465 138.080 175.671 1.00 42.10  ? 57  ILE A CA  1 
ATOM   249  C C   . ILE A 1 34  ? 150.973 138.218 175.510 1.00 42.10  ? 57  ILE A C   1 
ATOM   250  O O   . ILE A 1 34  ? 151.702 138.395 176.494 1.00 42.10  ? 57  ILE A O   1 
ATOM   251  C CB  . ILE A 1 34  ? 149.018 136.607 175.634 1.00 42.10  ? 57  ILE A CB  1 
ATOM   252  C CG1 . ILE A 1 34  ? 147.622 136.461 176.240 1.00 42.10  ? 57  ILE A CG1 1 
ATOM   253  C CG2 . ILE A 1 34  ? 150.011 135.725 176.372 1.00 42.10  ? 57  ILE A CG2 1 
ATOM   254  C CD1 . ILE A 1 34  ? 147.153 135.028 176.354 1.00 42.10  ? 57  ILE A CD1 1 
ATOM   255  N N   . ARG A 1 35  ? 151.467 138.153 174.272 1.00 44.61  ? 58  ARG A N   1 
ATOM   256  C CA  . ARG A 1 35  ? 152.902 138.281 174.046 1.00 44.61  ? 58  ARG A CA  1 
ATOM   257  C C   . ARG A 1 35  ? 153.406 139.697 174.288 1.00 44.61  ? 58  ARG A C   1 
ATOM   258  O O   . ARG A 1 35  ? 154.607 139.882 174.510 1.00 44.61  ? 58  ARG A O   1 
ATOM   259  C CB  . ARG A 1 35  ? 153.256 137.844 172.624 1.00 44.61  ? 58  ARG A CB  1 
ATOM   260  C CG  . ARG A 1 35  ? 152.975 136.379 172.333 1.00 44.61  ? 58  ARG A CG  1 
ATOM   261  C CD  . ARG A 1 35  ? 153.774 135.896 171.136 1.00 44.61  ? 58  ARG A CD  1 
ATOM   262  N NE  . ARG A 1 35  ? 153.632 136.786 169.988 1.00 44.61  ? 58  ARG A NE  1 
ATOM   263  C CZ  . ARG A 1 35  ? 152.729 136.625 169.026 1.00 44.61  ? 58  ARG A CZ  1 
ATOM   264  N NH1 . ARG A 1 35  ? 151.884 135.605 169.072 1.00 44.61  ? 58  ARG A NH1 1 
ATOM   265  N NH2 . ARG A 1 35  ? 152.672 137.484 168.017 1.00 44.61  ? 58  ARG A NH2 1 
ATOM   266  N N   . LEU A 1 36  ? 152.524 140.697 174.251 1.00 43.99  ? 59  LEU A N   1 
ATOM   267  C CA  . LEU A 1 36  ? 152.957 142.075 174.454 1.00 43.99  ? 59  LEU A CA  1 
ATOM   268  C C   . LEU A 1 36  ? 153.010 142.441 175.933 1.00 43.99  ? 59  LEU A C   1 
ATOM   269  O O   . LEU A 1 36  ? 153.930 143.141 176.368 1.00 43.99  ? 59  LEU A O   1 
ATOM   270  C CB  . LEU A 1 36  ? 152.029 143.030 173.702 1.00 43.99  ? 59  LEU A CB  1 
ATOM   271  C CG  . LEU A 1 36  ? 152.280 144.526 173.888 1.00 43.99  ? 59  LEU A CG  1 
ATOM   272  C CD1 . LEU A 1 36  ? 153.684 144.892 173.437 1.00 43.99  ? 59  LEU A CD1 1 
ATOM   273  C CD2 . LEU A 1 36  ? 151.243 145.338 173.132 1.00 43.99  ? 59  LEU A CD2 1 
ATOM   274  N N   . GLN A 1 37  ? 152.040 141.977 176.718 1.00 42.61  ? 60  GLN A N   1 
ATOM   275  C CA  . GLN A 1 37  ? 151.956 142.317 178.132 1.00 42.61  ? 60  GLN A CA  1 
ATOM   276  C C   . GLN A 1 37  ? 152.844 141.443 179.011 1.00 42.61  ? 60  GLN A C   1 
ATOM   277  O O   . GLN A 1 37  ? 152.735 141.526 180.240 1.00 42.61  ? 60  GLN A O   1 
ATOM   278  C CB  . GLN A 1 37  ? 150.505 142.218 178.608 1.00 42.61  ? 60  GLN A CB  1 
ATOM   279  C CG  . GLN A 1 37  ? 149.528 143.062 177.808 1.00 42.61  ? 60  GLN A CG  1 
ATOM   280  C CD  . GLN A 1 37  ? 149.671 144.543 178.082 1.00 42.61  ? 60  GLN A CD  1 
ATOM   281  O OE1 . GLN A 1 37  ? 150.209 144.945 179.111 1.00 42.61  ? 60  GLN A OE1 1 
ATOM   282  N NE2 . GLN A 1 37  ? 149.188 145.365 177.159 1.00 42.61  ? 60  GLN A NE2 1 
ATOM   283  N N   . ASN A 1 38  ? 153.709 140.619 178.416 1.00 44.00  ? 61  ASN A N   1 
ATOM   284  C CA  . ASN A 1 38  ? 154.602 139.728 179.160 1.00 44.00  ? 61  ASN A CA  1 
ATOM   285  C C   . ASN A 1 38  ? 153.811 138.790 180.072 1.00 44.00  ? 61  ASN A C   1 
ATOM   286  O O   . ASN A 1 38  ? 154.050 138.708 181.278 1.00 44.00  ? 61  ASN A O   1 
ATOM   287  C CB  . ASN A 1 38  ? 155.638 140.525 179.958 1.00 44.00  ? 61  ASN A CB  1 
ATOM   288  C CG  . ASN A 1 38  ? 156.420 141.494 179.095 1.00 44.00  ? 61  ASN A CG  1 
ATOM   289  O OD1 . ASN A 1 38  ? 156.519 141.321 177.881 1.00 44.00  ? 61  ASN A OD1 1 
ATOM   290  N ND2 . ASN A 1 38  ? 156.984 142.520 179.720 1.00 44.00  ? 61  ASN A ND2 1 
ATOM   291  N N   . LEU A 1 39  ? 152.858 138.076 179.481 1.00 47.64  ? 62  LEU A N   1 
ATOM   292  C CA  . LEU A 1 39  ? 151.990 137.151 180.198 1.00 47.64  ? 62  LEU A CA  1 
ATOM   293  C C   . LEU A 1 39  ? 152.159 135.728 179.677 1.00 47.64  ? 62  LEU A C   1 
ATOM   294  O O   . LEU A 1 39  ? 151.186 134.995 179.491 1.00 47.64  ? 62  LEU A O   1 
ATOM   295  C CB  . LEU A 1 39  ? 150.531 137.587 180.099 1.00 47.64  ? 62  LEU A CB  1 
ATOM   296  C CG  . LEU A 1 39  ? 150.169 138.945 180.702 1.00 47.64  ? 62  LEU A CG  1 
ATOM   297  C CD1 . LEU A 1 39  ? 148.736 139.315 180.360 1.00 47.64  ? 62  LEU A CD1 1 
ATOM   298  C CD2 . LEU A 1 39  ? 150.372 138.932 182.205 1.00 47.64  ? 62  LEU A CD2 1 
ATOM   299  N N   . ASN A 1 40  ? 153.404 135.320 179.437 1.00 53.63  ? 63  ASN A N   1 
ATOM   300  C CA  . ASN A 1 40  ? 153.687 134.004 178.881 1.00 53.63  ? 63  ASN A CA  1 
ATOM   301  C C   . ASN A 1 40  ? 153.902 132.934 179.945 1.00 53.63  ? 63  ASN A C   1 
ATOM   302  O O   . ASN A 1 40  ? 154.083 131.763 179.594 1.00 53.63  ? 63  ASN A O   1 
ATOM   303  C CB  . ASN A 1 40  ? 154.916 134.072 177.970 1.00 53.63  ? 63  ASN A CB  1 
ATOM   304  C CG  . ASN A 1 40  ? 154.694 133.378 176.642 1.00 53.63  ? 63  ASN A CG  1 
ATOM   305  O OD1 . ASN A 1 40  ? 153.911 132.434 176.546 1.00 53.63  ? 63  ASN A OD1 1 
ATOM   306  N ND2 . ASN A 1 40  ? 155.383 133.846 175.608 1.00 53.63  ? 63  ASN A ND2 1 
ATOM   307  N N   . THR A 1 41  ? 153.892 133.302 181.222 1.00 58.76  ? 64  THR A N   1 
ATOM   308  C CA  . THR A 1 41  ? 154.041 132.317 182.282 1.00 58.76  ? 64  THR A CA  1 
ATOM   309  C C   . THR A 1 41  ? 152.791 131.441 182.359 1.00 58.76  ? 64  THR A C   1 
ATOM   310  O O   . THR A 1 41  ? 151.672 131.944 182.220 1.00 58.76  ? 64  THR A O   1 
ATOM   311  C CB  . THR A 1 41  ? 154.278 133.014 183.623 1.00 58.76  ? 64  THR A CB  1 
ATOM   312  O OG1 . THR A 1 41  ? 155.193 134.101 183.441 1.00 58.76  ? 64  THR A OG1 1 
ATOM   313  C CG2 . THR A 1 41  ? 154.855 132.048 184.646 1.00 58.76  ? 64  THR A CG2 1 
ATOM   314  N N   . PRO A 1 42  ? 152.946 130.128 182.560 1.00 58.25  ? 65  PRO A N   1 
ATOM   315  C CA  . PRO A 1 42  ? 151.760 129.262 182.678 1.00 58.25  ? 65  PRO A CA  1 
ATOM   316  C C   . PRO A 1 42  ? 150.804 129.677 183.784 1.00 58.25  ? 65  PRO A C   1 
ATOM   317  O O   . PRO A 1 42  ? 149.585 129.536 183.619 1.00 58.25  ? 65  PRO A O   1 
ATOM   318  C CB  . PRO A 1 42  ? 152.368 127.880 182.947 1.00 58.25  ? 65  PRO A CB  1 
ATOM   319  C CG  . PRO A 1 42  ? 153.708 127.938 182.308 1.00 58.25  ? 65  PRO A CG  1 
ATOM   320  C CD  . PRO A 1 42  ? 154.194 129.348 182.495 1.00 58.25  ? 65  PRO A CD  1 
ATOM   321  N N   . ASP A 1 43  ? 151.315 130.185 184.908 1.00 58.66  ? 66  ASP A N   1 
ATOM   322  C CA  . ASP A 1 43  ? 150.428 130.666 185.963 1.00 58.66  ? 66  ASP A CA  1 
ATOM   323  C C   . ASP A 1 43  ? 149.622 131.871 185.494 1.00 58.66  ? 66  ASP A C   1 
ATOM   324  O O   . ASP A 1 43  ? 148.434 131.997 185.816 1.00 58.66  ? 66  ASP A O   1 
ATOM   325  C CB  . ASP A 1 43  ? 151.237 131.014 187.212 1.00 58.66  ? 66  ASP A CB  1 
ATOM   326  C CG  . ASP A 1 43  ? 151.965 129.815 187.786 1.00 58.66  ? 66  ASP A CG  1 
ATOM   327  O OD1 . ASP A 1 43  ? 151.828 128.709 187.221 1.00 58.66  ? 66  ASP A OD1 1 
ATOM   328  O OD2 . ASP A 1 43  ? 152.673 129.977 188.801 1.00 58.66  ? 66  ASP A OD2 1 
ATOM   329  N N   . LEU A 1 44  ? 150.247 132.759 184.719 1.00 54.87  ? 67  LEU A N   1 
ATOM   330  C CA  . LEU A 1 44  ? 149.525 133.912 184.193 1.00 54.87  ? 67  LEU A CA  1 
ATOM   331  C C   . LEU A 1 44  ? 148.450 133.483 183.202 1.00 54.87  ? 67  LEU A C   1 
ATOM   332  O O   . LEU A 1 44  ? 147.360 134.063 183.172 1.00 54.87  ? 67  LEU A O   1 
ATOM   333  C CB  . LEU A 1 44  ? 150.504 134.892 183.551 1.00 54.87  ? 67  LEU A CB  1 
ATOM   334  C CG  . LEU A 1 44  ? 151.579 135.429 184.499 1.00 54.87  ? 67  LEU A CG  1 
ATOM   335  C CD1 . LEU A 1 44  ? 152.542 136.353 183.772 1.00 54.87  ? 67  LEU A CD1 1 
ATOM   336  C CD2 . LEU A 1 44  ? 150.942 136.139 185.682 1.00 54.87  ? 67  LEU A CD2 1 
ATOM   337  N N   . ARG A 1 45  ? 148.724 132.452 182.399 1.00 56.40  ? 68  ARG A N   1 
ATOM   338  C CA  . ARG A 1 45  ? 147.704 131.955 181.480 1.00 56.40  ? 68  ARG A CA  1 
ATOM   339  C C   . ARG A 1 45  ? 146.568 131.273 182.232 1.00 56.40  ? 68  ARG A C   1 
ATOM   340  O O   . ARG A 1 45  ? 145.401 131.372 181.832 1.00 56.40  ? 68  ARG A O   1 
ATOM   341  C CB  . ARG A 1 45  ? 148.331 131.002 180.464 1.00 56.40  ? 68  ARG A CB  1 
ATOM   342  C CG  . ARG A 1 45  ? 149.295 131.682 179.510 1.00 56.40  ? 68  ARG A CG  1 
ATOM   343  C CD  . ARG A 1 45  ? 149.490 130.873 178.241 1.00 56.40  ? 68  ARG A CD  1 
ATOM   344  N NE  . ARG A 1 45  ? 150.328 131.579 177.278 1.00 56.40  ? 68  ARG A NE  1 
ATOM   345  C CZ  . ARG A 1 45  ? 150.517 131.187 176.023 1.00 56.40  ? 68  ARG A CZ  1 
ATOM   346  N NH1 . ARG A 1 45  ? 149.925 130.090 175.573 1.00 56.40  ? 68  ARG A NH1 1 
ATOM   347  N NH2 . ARG A 1 45  ? 151.297 131.893 175.217 1.00 56.40  ? 68  ARG A NH2 1 
ATOM   348  N N   . ALA A 1 46  ? 146.885 130.579 183.328 1.00 57.87  ? 69  ALA A N   1 
ATOM   349  C CA  . ALA A 1 46  ? 145.833 129.998 184.154 1.00 57.87  ? 69  ALA A CA  1 
ATOM   350  C C   . ALA A 1 46  ? 144.961 131.085 184.769 1.00 57.87  ? 69  ALA A C   1 
ATOM   351  O O   . ALA A 1 46  ? 143.733 130.949 184.828 1.00 57.87  ? 69  ALA A O   1 
ATOM   352  C CB  . ALA A 1 46  ? 146.442 129.114 185.241 1.00 57.87  ? 69  ALA A CB  1 
ATOM   353  N N   . ALA A 1 47  ? 145.580 132.175 185.229 1.00 58.31  ? 70  ALA A N   1 
ATOM   354  C CA  . ALA A 1 47  ? 144.808 133.299 185.748 1.00 58.31  ? 70  ALA A CA  1 
ATOM   355  C C   . ALA A 1 47  ? 143.970 133.944 184.650 1.00 58.31  ? 70  ALA A C   1 
ATOM   356  O O   . ALA A 1 47  ? 142.861 134.428 184.907 1.00 58.31  ? 70  ALA A O   1 
ATOM   357  C CB  . ALA A 1 47  ? 145.739 134.327 186.388 1.00 58.31  ? 70  ALA A CB  1 
ATOM   358  N N   . CYS A 1 48  ? 144.491 133.970 183.422 1.00 60.18  ? 71  CYS A N   1 
ATOM   359  C CA  . CYS A 1 48  ? 143.717 134.467 182.288 1.00 60.18  ? 71  CYS A CA  1 
ATOM   360  C C   . CYS A 1 48  ? 142.460 133.633 182.078 1.00 60.18  ? 71  CYS A C   1 
ATOM   361  O O   . CYS A 1 48  ? 141.346 134.167 182.020 1.00 60.18  ? 71  CYS A O   1 
ATOM   362  C CB  . CYS A 1 48  ? 144.576 134.456 181.023 1.00 60.18  ? 71  CYS A CB  1 
ATOM   363  S SG  . CYS A 1 48  ? 145.586 135.927 180.754 1.00 60.18  ? 71  CYS A SG  1 
ATOM   364  N N   . THR A 1 49  ? 142.623 132.314 181.959 1.00 61.30  ? 72  THR A N   1 
ATOM   365  C CA  . THR A 1 49  ? 141.477 131.440 181.722 1.00 61.30  ? 72  THR A CA  1 
ATOM   366  C C   . THR A 1 49  ? 140.551 131.341 182.927 1.00 61.30  ? 72  THR A C   1 
ATOM   367  O O   . THR A 1 49  ? 139.398 130.925 182.770 1.00 61.30  ? 72  THR A O   1 
ATOM   368  C CB  . THR A 1 49  ? 141.939 130.037 181.319 1.00 61.30  ? 72  THR A CB  1 
ATOM   369  O OG1 . THR A 1 49  ? 142.412 129.335 182.475 1.00 61.30  ? 72  THR A OG1 1 
ATOM   370  C CG2 . THR A 1 49  ? 143.036 130.106 180.267 1.00 61.30  ? 72  THR A CG2 1 
ATOM   371  N N   . GLN A 1 50  ? 141.021 131.702 184.123 1.00 66.71  ? 73  GLN A N   1 
ATOM   372  C CA  . GLN A 1 50  ? 140.163 131.637 185.302 1.00 66.71  ? 73  GLN A CA  1 
ATOM   373  C C   . GLN A 1 50  ? 139.087 132.717 185.260 1.00 66.71  ? 73  GLN A C   1 
ATOM   374  O O   . GLN A 1 50  ? 137.888 132.417 185.245 1.00 66.71  ? 73  GLN A O   1 
ATOM   375  C CB  . GLN A 1 50  ? 141.006 131.761 186.572 1.00 66.71  ? 73  GLN A CB  1 
ATOM   376  C CG  . GLN A 1 50  ? 140.189 131.751 187.853 1.00 66.71  ? 73  GLN A CG  1 
ATOM   377  C CD  . GLN A 1 50  ? 141.045 131.913 189.093 1.00 66.71  ? 73  GLN A CD  1 
ATOM   378  O OE1 . GLN A 1 50  ? 142.266 132.050 189.006 1.00 66.71  ? 73  GLN A OE1 1 
ATOM   379  N NE2 . GLN A 1 50  ? 140.408 131.895 190.257 1.00 66.71  ? 73  GLN A NE2 1 
ATOM   380  N N   . HIS A 1 51  ? 139.498 133.983 185.238 1.00 67.03  ? 74  HIS A N   1 
ATOM   381  C CA  . HIS A 1 51  ? 138.553 135.095 185.171 1.00 67.03  ? 74  HIS A CA  1 
ATOM   382  C C   . HIS A 1 51  ? 137.948 135.155 183.775 1.00 67.03  ? 74  HIS A C   1 
ATOM   383  O O   . HIS A 1 51  ? 138.646 135.449 182.800 1.00 67.03  ? 74  HIS A O   1 
ATOM   384  C CB  . HIS A 1 51  ? 139.251 136.406 185.517 1.00 67.03  ? 74  HIS A CB  1 
ATOM   385  C CG  . HIS A 1 51  ? 139.831 136.437 186.897 1.00 67.03  ? 74  HIS A CG  1 
ATOM   386  N ND1 . HIS A 1 51  ? 140.911 135.664 187.267 1.00 67.03  ? 74  HIS A ND1 1 
ATOM   387  C CD2 . HIS A 1 51  ? 139.484 137.148 187.995 1.00 67.03  ? 74  HIS A CD2 1 
ATOM   388  C CE1 . HIS A 1 51  ? 141.202 135.895 188.534 1.00 67.03  ? 74  HIS A CE1 1 
ATOM   389  N NE2 . HIS A 1 51  ? 140.351 136.792 188.999 1.00 67.03  ? 74  HIS A NE2 1 
ATOM   390  N N   . SER A 1 52  ? 136.651 134.877 183.672 1.00 63.97  ? 75  SER A N   1 
ATOM   391  C CA  . SER A 1 52  ? 135.949 134.878 182.398 1.00 63.97  ? 75  SER A CA  1 
ATOM   392  C C   . SER A 1 52  ? 134.694 135.729 182.517 1.00 63.97  ? 75  SER A C   1 
ATOM   393  O O   . SER A 1 52  ? 133.926 135.586 183.473 1.00 63.97  ? 75  SER A O   1 
ATOM   394  C CB  . SER A 1 52  ? 135.580 133.450 181.963 1.00 63.97  ? 75  SER A CB  1 
ATOM   395  O OG  . SER A 1 52  ? 136.689 132.777 181.388 1.00 63.97  ? 75  SER A OG  1 
ATOM   396  N N   . VAL A 1 53  ? 134.494 136.614 181.548 1.00 55.71  ? 76  VAL A N   1 
ATOM   397  C CA  . VAL A 1 53  ? 133.303 137.454 181.517 1.00 55.71  ? 76  VAL A CA  1 
ATOM   398  C C   . VAL A 1 53  ? 132.137 136.636 180.982 1.00 55.71  ? 76  VAL A C   1 
ATOM   399  O O   . VAL A 1 53  ? 132.306 135.784 180.101 1.00 55.71  ? 76  VAL A O   1 
ATOM   400  C CB  . VAL A 1 53  ? 133.559 138.718 180.674 1.00 55.71  ? 76  VAL A CB  1 
ATOM   401  C CG1 . VAL A 1 53  ? 134.005 138.349 179.271 1.00 55.71  ? 76  VAL A CG1 1 
ATOM   402  C CG2 . VAL A 1 53  ? 132.336 139.627 180.656 1.00 55.71  ? 76  VAL A CG2 1 
ATOM   403  N N   . ALA A 1 54  ? 130.948 136.884 181.524 1.00 52.93  ? 77  ALA A N   1 
ATOM   404  C CA  . ALA A 1 54  ? 129.763 136.106 181.178 1.00 52.93  ? 77  ALA A CA  1 
ATOM   405  C C   . ALA A 1 54  ? 129.290 136.466 179.775 1.00 52.93  ? 77  ALA A C   1 
ATOM   406  O O   . ALA A 1 54  ? 128.792 137.572 179.544 1.00 52.93  ? 77  ALA A O   1 
ATOM   407  C CB  . ALA A 1 54  ? 128.662 136.349 182.205 1.00 52.93  ? 77  ALA A CB  1 
ATOM   408  N N   . PHE A 1 55  ? 129.444 135.528 178.834 1.00 44.07  ? 78  PHE A N   1 
ATOM   409  C CA  . PHE A 1 55  ? 128.943 135.639 177.473 1.00 44.07  ? 78  PHE A CA  1 
ATOM   410  C C   . PHE A 1 55  ? 127.838 134.614 177.233 1.00 44.07  ? 78  PHE A C   1 
ATOM   411  O O   . PHE A 1 55  ? 127.777 133.590 177.921 1.00 44.07  ? 78  PHE A O   1 
ATOM   412  C CB  . PHE A 1 55  ? 130.057 135.422 176.441 1.00 44.07  ? 78  PHE A CB  1 
ATOM   413  C CG  . PHE A 1 55  ? 130.748 136.686 176.018 1.00 44.07  ? 78  PHE A CG  1 
ATOM   414  C CD1 . PHE A 1 55  ? 130.132 137.571 175.153 1.00 44.07  ? 78  PHE A CD1 1 
ATOM   415  C CD2 . PHE A 1 55  ? 132.020 136.982 176.474 1.00 44.07  ? 78  PHE A CD2 1 
ATOM   416  C CE1 . PHE A 1 55  ? 130.767 138.731 174.762 1.00 44.07  ? 78  PHE A CE1 1 
ATOM   417  C CE2 . PHE A 1 55  ? 132.657 138.140 176.082 1.00 44.07  ? 78  PHE A CE2 1 
ATOM   418  C CZ  . PHE A 1 55  ? 132.029 139.015 175.225 1.00 44.07  ? 78  PHE A CZ  1 
ATOM   419  N N   . PRO A 1 56  ? 126.942 134.861 176.277 1.00 44.41  ? 79  PRO A N   1 
ATOM   420  C CA  . PRO A 1 56  ? 125.903 133.868 175.971 1.00 44.41  ? 79  PRO A CA  1 
ATOM   421  C C   . PRO A 1 56  ? 126.511 132.555 175.498 1.00 44.41  ? 79  PRO A C   1 
ATOM   422  O O   . PRO A 1 56  ? 127.412 132.533 174.657 1.00 44.41  ? 79  PRO A O   1 
ATOM   423  C CB  . PRO A 1 56  ? 125.082 134.544 174.867 1.00 44.41  ? 79  PRO A CB  1 
ATOM   424  C CG  . PRO A 1 56  ? 125.330 135.998 175.048 1.00 44.41  ? 79  PRO A CG  1 
ATOM   425  C CD  . PRO A 1 56  ? 126.747 136.111 175.523 1.00 44.41  ? 79  PRO A CD  1 
ATOM   426  N N   . SER A 1 57  ? 126.007 131.454 176.050 1.00 52.34  ? 80  SER A N   1 
ATOM   427  C CA  . SER A 1 57  ? 126.537 130.137 175.733 1.00 52.34  ? 80  SER A CA  1 
ATOM   428  C C   . SER A 1 57  ? 126.083 129.702 174.340 1.00 52.34  ? 80  SER A C   1 
ATOM   429  O O   . SER A 1 57  ? 125.346 130.404 173.643 1.00 52.34  ? 80  SER A O   1 
ATOM   430  C CB  . SER A 1 57  ? 126.103 129.124 176.790 1.00 52.34  ? 80  SER A CB  1 
ATOM   431  O OG  . SER A 1 57  ? 126.370 127.799 176.364 1.00 52.34  ? 80  SER A OG  1 
ATOM   432  N N   . GLU A 1 58  ? 126.536 128.515 173.933 1.00 54.80  ? 81  GLU A N   1 
ATOM   433  C CA  . GLU A 1 58  ? 126.194 128.000 172.612 1.00 54.80  ? 81  GLU A CA  1 
ATOM   434  C C   . GLU A 1 58  ? 124.781 127.430 172.576 1.00 54.80  ? 81  GLU A C   1 
ATOM   435  O O   . GLU A 1 58  ? 124.059 127.618 171.589 1.00 54.80  ? 81  GLU A O   1 
ATOM   436  C CB  . GLU A 1 58  ? 127.207 126.937 172.187 1.00 54.80  ? 81  GLU A CB  1 
ATOM   437  C CG  . GLU A 1 58  ? 127.013 126.430 170.770 1.00 54.80  ? 81  GLU A CG  1 
ATOM   438  C CD  . GLU A 1 58  ? 127.952 125.291 170.428 1.00 54.80  ? 81  GLU A CD  1 
ATOM   439  O OE1 . GLU A 1 58  ? 128.362 124.558 171.352 1.00 54.80  ? 81  GLU A OE1 1 
ATOM   440  O OE2 . GLU A 1 58  ? 128.278 125.129 169.234 1.00 54.80  ? 81  GLU A OE2 1 
ATOM   441  N N   . ASP A 1 59  ? 124.369 126.733 173.637 1.00 55.95  ? 82  ASP A N   1 
ATOM   442  C CA  . ASP A 1 59  ? 123.027 126.161 173.665 1.00 55.95  ? 82  ASP A CA  1 
ATOM   443  C C   . ASP A 1 59  ? 121.963 127.250 173.692 1.00 55.95  ? 82  ASP A C   1 
ATOM   444  O O   . ASP A 1 59  ? 120.896 127.099 173.085 1.00 55.95  ? 82  ASP A O   1 
ATOM   445  C CB  . ASP A 1 59  ? 122.877 125.231 174.868 1.00 55.95  ? 82  ASP A CB  1 
ATOM   446  C CG  . ASP A 1 59  ? 121.954 124.062 174.586 1.00 55.95  ? 82  ASP A CG  1 
ATOM   447  O OD1 . ASP A 1 59  ? 121.400 123.996 173.469 1.00 55.95  ? 82  ASP A OD1 1 
ATOM   448  O OD2 . ASP A 1 59  ? 121.783 123.208 175.482 1.00 55.95  ? 82  ASP A OD2 1 
ATOM   449  N N   . THR A 1 60  ? 122.237 128.357 174.387 1.00 55.43  ? 83  THR A N   1 
ATOM   450  C CA  . THR A 1 60  ? 121.291 129.467 174.406 1.00 55.43  ? 83  THR A CA  1 
ATOM   451  C C   . THR A 1 60  ? 121.127 130.071 173.017 1.00 55.43  ? 83  THR A C   1 
ATOM   452  O O   . THR A 1 60  ? 120.010 130.400 172.602 1.00 55.43  ? 83  THR A O   1 
ATOM   453  C CB  . THR A 1 60  ? 121.750 130.531 175.404 1.00 55.43  ? 83  THR A CB  1 
ATOM   454  O OG1 . THR A 1 60  ? 121.824 129.956 176.714 1.00 55.43  ? 83  THR A OG1 1 
ATOM   455  C CG2 . THR A 1 60  ? 120.777 131.699 175.427 1.00 55.43  ? 83  THR A CG2 1 
ATOM   456  N N   . LEU A 1 61  ? 122.230 130.213 172.277 1.00 49.86  ? 84  LEU A N   1 
ATOM   457  C CA  . LEU A 1 61  ? 122.144 130.747 170.922 1.00 49.86  ? 84  LEU A CA  1 
ATOM   458  C C   . LEU A 1 61  ? 121.449 129.768 169.983 1.00 49.86  ? 84  LEU A C   1 
ATOM   459  O O   . LEU A 1 61  ? 120.735 130.183 169.064 1.00 49.86  ? 84  LEU A O   1 
ATOM   460  C CB  . LEU A 1 61  ? 123.539 131.090 170.401 1.00 49.86  ? 84  LEU A CB  1 
ATOM   461  C CG  . LEU A 1 61  ? 124.233 132.286 171.052 1.00 49.86  ? 84  LEU A CG  1 
ATOM   462  C CD1 . LEU A 1 61  ? 125.594 132.524 170.420 1.00 49.86  ? 84  LEU A CD1 1 
ATOM   463  C CD2 . LEU A 1 61  ? 123.365 133.529 170.946 1.00 49.86  ? 84  LEU A CD2 1 
ATOM   464  N N   . ARG A 1 62  ? 121.646 128.465 170.197 1.00 55.58  ? 85  ARG A N   1 
ATOM   465  C CA  . ARG A 1 62  ? 121.005 127.478 169.334 1.00 55.58  ? 85  ARG A CA  1 
ATOM   466  C C   . ARG A 1 62  ? 119.520 127.336 169.640 1.00 55.58  ? 85  ARG A C   1 
ATOM   467  O O   . ARG A 1 62  ? 118.746 126.928 168.767 1.00 55.58  ? 85  ARG A O   1 
ATOM   468  C CB  . ARG A 1 62  ? 121.703 126.125 169.470 1.00 55.58  ? 85  ARG A CB  1 
ATOM   469  C CG  . ARG A 1 62  ? 123.047 126.050 168.766 1.00 55.58  ? 85  ARG A CG  1 
ATOM   470  C CD  . ARG A 1 62  ? 123.647 124.658 168.868 1.00 55.58  ? 85  ARG A CD  1 
ATOM   471  N NE  . ARG A 1 62  ? 124.909 124.557 168.142 1.00 55.58  ? 85  ARG A NE  1 
ATOM   472  C CZ  . ARG A 1 62  ? 125.673 123.470 168.120 1.00 55.58  ? 85  ARG A CZ  1 
ATOM   473  N NH1 . ARG A 1 62  ? 125.303 122.384 168.786 1.00 55.58  ? 85  ARG A NH1 1 
ATOM   474  N NH2 . ARG A 1 62  ? 126.806 123.467 167.433 1.00 55.58  ? 85  ARG A NH2 1 
ATOM   475  N N   . GLN A 1 63  ? 119.103 127.661 170.865 1.00 57.98  ? 86  GLN A N   1 
ATOM   476  C CA  . GLN A 1 63  ? 117.698 127.520 171.230 1.00 57.98  ? 86  GLN A CA  1 
ATOM   477  C C   . GLN A 1 63  ? 116.849 128.682 170.725 1.00 57.98  ? 86  GLN A C   1 
ATOM   478  O O   . GLN A 1 63  ? 115.645 128.511 170.502 1.00 57.98  ? 86  GLN A O   1 
ATOM   479  C CB  . GLN A 1 63  ? 117.564 127.392 172.748 1.00 57.98  ? 86  GLN A CB  1 
ATOM   480  C CG  . GLN A 1 63  ? 116.212 126.878 173.214 1.00 57.98  ? 86  GLN A CG  1 
ATOM   481  C CD  . GLN A 1 63  ? 116.175 126.608 174.705 1.00 57.98  ? 86  GLN A CD  1 
ATOM   482  O OE1 . GLN A 1 63  ? 117.145 126.860 175.418 1.00 57.98  ? 86  GLN A OE1 1 
ATOM   483  N NE2 . GLN A 1 63  ? 115.050 126.089 175.184 1.00 57.98  ? 86  GLN A NE2 1 
ATOM   484  N N   . LEU A 1 64  ? 117.447 129.855 170.534 1.00 56.16  ? 87  LEU A N   1 
ATOM   485  C CA  . LEU A 1 64  ? 116.691 131.025 170.114 1.00 56.16  ? 87  LEU A CA  1 
ATOM   486  C C   . LEU A 1 64  ? 116.284 130.920 168.646 1.00 56.16  ? 87  LEU A C   1 
ATOM   487  O O   . LEU A 1 64  ? 116.815 130.113 167.877 1.00 56.16  ? 87  LEU A O   1 
ATOM   488  C CB  . LEU A 1 64  ? 117.508 132.299 170.332 1.00 56.16  ? 87  LEU A CB  1 
ATOM   489  C CG  . LEU A 1 64  ? 117.797 132.690 171.781 1.00 56.16  ? 87  LEU A CG  1 
ATOM   490  C CD1 . LEU A 1 64  ? 118.625 133.963 171.834 1.00 56.16  ? 87  LEU A CD1 1 
ATOM   491  C CD2 . LEU A 1 64  ? 116.501 132.856 172.559 1.00 56.16  ? 87  LEU A CD2 1 
ATOM   492  N N   . SER A 1 65  ? 115.322 131.756 168.264 1.00 60.97  ? 88  SER A N   1 
ATOM   493  C CA  . SER A 1 65  ? 114.879 131.851 166.880 1.00 60.97  ? 88  SER A CA  1 
ATOM   494  C C   . SER A 1 65  ? 115.863 132.718 166.096 1.00 60.97  ? 88  SER A C   1 
ATOM   495  O O   . SER A 1 65  ? 116.926 133.099 166.593 1.00 60.97  ? 88  SER A O   1 
ATOM   496  C CB  . SER A 1 65  ? 113.454 132.394 166.816 1.00 60.97  ? 88  SER A CB  1 
ATOM   497  O OG  . SER A 1 65  ? 112.984 132.431 165.481 1.00 60.97  ? 88  SER A OG  1 
ATOM   498  N N   . LYS A 1 66  ? 115.516 133.048 164.848 1.00 60.19  ? 89  LYS A N   1 
ATOM   499  C CA  . LYS A 1 66  ? 116.440 133.822 164.018 1.00 60.19  ? 89  LYS A CA  1 
ATOM   500  C C   . LYS A 1 66  ? 116.456 135.304 164.380 1.00 60.19  ? 89  LYS A C   1 
ATOM   501  O O   . LYS A 1 66  ? 117.556 135.855 164.575 1.00 60.19  ? 89  LYS A O   1 
ATOM   502  C CB  . LYS A 1 66  ? 116.118 133.598 162.537 1.00 60.19  ? 89  LYS A CB  1 
ATOM   503  C CG  . LYS A 1 66  ? 116.126 132.137 162.123 1.00 60.19  ? 89  LYS A CG  1 
ATOM   504  C CD  . LYS A 1 66  ? 115.766 131.975 160.657 1.00 60.19  ? 89  LYS A CD  1 
ATOM   505  C CE  . LYS A 1 66  ? 115.824 130.517 160.233 1.00 60.19  ? 89  LYS A CE  1 
ATOM   506  N NZ  . LYS A 1 66  ? 115.579 130.353 158.773 1.00 60.19  ? 89  LYS A NZ  1 
ATOM   507  N N   . PRO A 1 67  ? 115.319 136.011 164.473 1.00 57.33  ? 90  PRO A N   1 
ATOM   508  C CA  . PRO A 1 67  ? 115.400 137.445 164.808 1.00 57.33  ? 90  PRO A CA  1 
ATOM   509  C C   . PRO A 1 67  ? 115.979 137.707 166.187 1.00 57.33  ? 90  PRO A C   1 
ATOM   510  O O   . PRO A 1 67  ? 116.760 138.654 166.359 1.00 57.33  ? 90  PRO A O   1 
ATOM   511  C CB  . PRO A 1 67  ? 113.940 137.912 164.705 1.00 57.33  ? 90  PRO A CB  1 
ATOM   512  C CG  . PRO A 1 67  ? 113.262 136.883 163.868 1.00 57.33  ? 90  PRO A CG  1 
ATOM   513  C CD  . PRO A 1 67  ? 113.926 135.599 164.227 1.00 57.33  ? 90  PRO A CD  1 
ATOM   514  N N   . HIS A 1 68  ? 115.616 136.892 167.179 1.00 53.54  ? 91  HIS A N   1 
ATOM   515  C CA  . HIS A 1 68  ? 116.202 137.046 168.506 1.00 53.54  ? 91  HIS A CA  1 
ATOM   516  C C   . HIS A 1 68  ? 117.704 136.803 168.469 1.00 53.54  ? 91  HIS A C   1 
ATOM   517  O O   . HIS A 1 68  ? 118.471 137.506 169.137 1.00 53.54  ? 91  HIS A O   1 
ATOM   518  C CB  . HIS A 1 68  ? 115.526 136.095 169.494 1.00 53.54  ? 91  HIS A CB  1 
ATOM   519  C CG  . HIS A 1 68  ? 114.036 136.227 169.538 1.00 53.54  ? 91  HIS A CG  1 
ATOM   520  N ND1 . HIS A 1 68  ? 113.211 135.681 168.578 1.00 53.54  ? 91  HIS A ND1 1 
ATOM   521  C CD2 . HIS A 1 68  ? 113.221 136.843 170.426 1.00 53.54  ? 91  HIS A CD2 1 
ATOM   522  C CE1 . HIS A 1 68  ? 111.953 135.955 168.873 1.00 53.54  ? 91  HIS A CE1 1 
ATOM   523  N NE2 . HIS A 1 68  ? 111.931 136.659 169.990 1.00 53.54  ? 91  HIS A NE2 1 
ATOM   524  N N   . PHE A 1 69  ? 118.143 135.815 167.686 1.00 49.43  ? 92  PHE A N   1 
ATOM   525  C CA  . PHE A 1 69  ? 119.572 135.552 167.553 1.00 49.43  ? 92  PHE A CA  1 
ATOM   526  C C   . PHE A 1 69  ? 120.293 136.745 166.940 1.00 49.43  ? 92  PHE A C   1 
ATOM   527  O O   . PHE A 1 69  ? 121.365 137.145 167.414 1.00 49.43  ? 92  PHE A O   1 
ATOM   528  C CB  . PHE A 1 69  ? 119.788 134.292 166.715 1.00 49.43  ? 92  PHE A CB  1 
ATOM   529  C CG  . PHE A 1 69  ? 121.209 134.075 166.290 1.00 49.43  ? 92  PHE A CG  1 
ATOM   530  C CD1 . PHE A 1 69  ? 121.572 134.201 164.961 1.00 49.43  ? 92  PHE A CD1 1 
ATOM   531  C CD2 . PHE A 1 69  ? 122.180 133.736 167.215 1.00 49.43  ? 92  PHE A CD2 1 
ATOM   532  C CE1 . PHE A 1 69  ? 122.876 133.998 164.563 1.00 49.43  ? 92  PHE A CE1 1 
ATOM   533  C CE2 . PHE A 1 69  ? 123.487 133.532 166.822 1.00 49.43  ? 92  PHE A CE2 1 
ATOM   534  C CZ  . PHE A 1 69  ? 123.835 133.663 165.494 1.00 49.43  ? 92  PHE A CZ  1 
ATOM   535  N N   . LEU A 1 70  ? 119.711 137.338 165.894 1.00 48.65  ? 93  LEU A N   1 
ATOM   536  C CA  . LEU A 1 70  ? 120.326 138.509 165.277 1.00 48.65  ? 93  LEU A CA  1 
ATOM   537  C C   . LEU A 1 70  ? 120.390 139.679 166.252 1.00 48.65  ? 93  LEU A C   1 
ATOM   538  O O   . LEU A 1 70  ? 121.401 140.391 166.316 1.00 48.65  ? 93  LEU A O   1 
ATOM   539  C CB  . LEU A 1 70  ? 119.559 138.901 164.015 1.00 48.65  ? 93  LEU A CB  1 
ATOM   540  C CG  . LEU A 1 70  ? 119.534 137.865 162.890 1.00 48.65  ? 93  LEU A CG  1 
ATOM   541  C CD1 . LEU A 1 70  ? 118.785 138.401 161.680 1.00 48.65  ? 93  LEU A CD1 1 
ATOM   542  C CD2 . LEU A 1 70  ? 120.944 137.446 162.508 1.00 48.65  ? 93  LEU A CD2 1 
ATOM   543  N N   . SER A 1 71  ? 119.325 139.887 167.031 1.00 48.34  ? 94  SER A N   1 
ATOM   544  C CA  . SER A 1 71  ? 119.317 140.986 167.993 1.00 48.34  ? 94  SER A CA  1 
ATOM   545  C C   . SER A 1 71  ? 120.363 140.781 169.085 1.00 48.34  ? 94  SER A C   1 
ATOM   546  O O   . SER A 1 71  ? 121.056 141.731 169.476 1.00 48.34  ? 94  SER A O   1 
ATOM   547  C CB  . SER A 1 71  ? 117.924 141.137 168.604 1.00 48.34  ? 94  SER A CB  1 
ATOM   548  O OG  . SER A 1 71  ? 117.066 141.862 167.742 1.00 48.34  ? 94  SER A OG  1 
ATOM   549  N N   . THR A 1 72  ? 120.488 139.552 169.595 1.00 43.21  ? 95  THR A N   1 
ATOM   550  C CA  . THR A 1 72  ? 121.497 139.286 170.614 1.00 43.21  ? 95  THR A CA  1 
ATOM   551  C C   . THR A 1 72  ? 122.904 139.460 170.058 1.00 43.21  ? 95  THR A C   1 
ATOM   552  O O   . THR A 1 72  ? 123.787 139.982 170.747 1.00 43.21  ? 95  THR A O   1 
ATOM   553  C CB  . THR A 1 72  ? 121.324 137.882 171.194 1.00 43.21  ? 95  THR A CB  1 
ATOM   554  O OG1 . THR A 1 72  ? 121.515 136.906 170.162 1.00 43.21  ? 95  THR A OG1 1 
ATOM   555  C CG2 . THR A 1 72  ? 119.949 137.719 171.824 1.00 43.21  ? 95  THR A CG2 1 
ATOM   556  N N   . VAL A 1 73  ? 123.134 139.030 168.814 1.00 41.23  ? 96  VAL A N   1 
ATOM   557  C CA  . VAL A 1 73  ? 124.441 139.243 168.197 1.00 41.23  ? 96  VAL A CA  1 
ATOM   558  C C   . VAL A 1 73  ? 124.734 140.733 168.076 1.00 41.23  ? 96  VAL A C   1 
ATOM   559  O O   . VAL A 1 73  ? 125.850 141.188 168.360 1.00 41.23  ? 96  VAL A O   1 
ATOM   560  C CB  . VAL A 1 73  ? 124.510 138.533 166.832 1.00 41.23  ? 96  VAL A CB  1 
ATOM   561  C CG1 . VAL A 1 73  ? 125.720 139.008 166.046 1.00 41.23  ? 96  VAL A CG1 1 
ATOM   562  C CG2 . VAL A 1 73  ? 124.563 137.028 167.024 1.00 41.23  ? 96  VAL A CG2 1 
ATOM   563  N N   . TYR A 1 74  ? 123.733 141.518 167.667 1.00 41.64  ? 97  TYR A N   1 
ATOM   564  C CA  . TYR A 1 74  ? 123.905 142.964 167.556 1.00 41.64  ? 97  TYR A CA  1 
ATOM   565  C C   . TYR A 1 74  ? 124.290 143.579 168.898 1.00 41.64  ? 97  TYR A C   1 
ATOM   566  O O   . TYR A 1 74  ? 125.258 144.347 168.994 1.00 41.64  ? 97  TYR A O   1 
ATOM   567  C CB  . TYR A 1 74  ? 122.615 143.589 167.024 1.00 41.64  ? 97  TYR A CB  1 
ATOM   568  C CG  . TYR A 1 74  ? 122.809 144.822 166.173 1.00 41.64  ? 97  TYR A CG  1 
ATOM   569  C CD1 . TYR A 1 74  ? 122.619 146.092 166.700 1.00 41.64  ? 97  TYR A CD1 1 
ATOM   570  C CD2 . TYR A 1 74  ? 123.170 144.717 164.837 1.00 41.64  ? 97  TYR A CD2 1 
ATOM   571  C CE1 . TYR A 1 74  ? 122.790 147.221 165.923 1.00 41.64  ? 97  TYR A CE1 1 
ATOM   572  C CE2 . TYR A 1 74  ? 123.344 145.840 164.053 1.00 41.64  ? 97  TYR A CE2 1 
ATOM   573  C CZ  . TYR A 1 74  ? 123.152 147.088 164.601 1.00 41.64  ? 97  TYR A CZ  1 
ATOM   574  O OH  . TYR A 1 74  ? 123.324 148.209 163.824 1.00 41.64  ? 97  TYR A OH  1 
ATOM   575  N N   . THR A 1 75  ? 123.542 143.241 169.952 1.00 41.42  ? 98  THR A N   1 
ATOM   576  C CA  . THR A 1 75  ? 123.806 143.822 171.266 1.00 41.42  ? 98  THR A CA  1 
ATOM   577  C C   . THR A 1 75  ? 125.173 143.401 171.798 1.00 41.42  ? 98  THR A C   1 
ATOM   578  O O   . THR A 1 75  ? 125.907 144.219 172.372 1.00 41.42  ? 98  THR A O   1 
ATOM   579  C CB  . THR A 1 75  ? 122.704 143.420 172.247 1.00 41.42  ? 98  THR A CB  1 
ATOM   580  O OG1 . THR A 1 75  ? 121.431 143.817 171.724 1.00 41.42  ? 98  THR A OG1 1 
ATOM   581  C CG2 . THR A 1 75  ? 122.920 144.088 173.595 1.00 41.42  ? 98  THR A CG2 1 
ATOM   582  N N   . THR A 1 76  ? 125.535 142.129 171.616 1.00 39.37  ? 99  THR A N   1 
ATOM   583  C CA  . THR A 1 76  ? 126.826 141.653 172.098 1.00 39.37  ? 99  THR A CA  1 
ATOM   584  C C   . THR A 1 76  ? 127.974 142.325 171.356 1.00 39.37  ? 99  THR A C   1 
ATOM   585  O O   . THR A 1 76  ? 128.987 142.684 171.967 1.00 39.37  ? 99  THR A O   1 
ATOM   586  C CB  . THR A 1 76  ? 126.908 140.135 171.957 1.00 39.37  ? 99  THR A CB  1 
ATOM   587  O OG1 . THR A 1 76  ? 125.752 139.537 172.557 1.00 39.37  ? 99  THR A OG1 1 
ATOM   588  C CG2 . THR A 1 76  ? 128.150 139.610 172.644 1.00 39.37  ? 99  THR A CG2 1 
ATOM   589  N N   . LEU A 1 77  ? 127.832 142.514 170.041 1.00 39.26  ? 100 LEU A N   1 
ATOM   590  C CA  . LEU A 1 77  ? 128.870 143.211 169.290 1.00 39.26  ? 100 LEU A CA  1 
ATOM   591  C C   . LEU A 1 77  ? 128.982 144.666 169.729 1.00 39.26  ? 100 LEU A C   1 
ATOM   592  O O   . LEU A 1 77  ? 130.087 145.219 169.784 1.00 39.26  ? 100 LEU A O   1 
ATOM   593  C CB  . LEU A 1 77  ? 128.589 143.116 167.792 1.00 39.26  ? 100 LEU A CB  1 
ATOM   594  C CG  . LEU A 1 77  ? 128.839 141.743 167.165 1.00 39.26  ? 100 LEU A CG  1 
ATOM   595  C CD1 . LEU A 1 77  ? 128.495 141.757 165.687 1.00 39.26  ? 100 LEU A CD1 1 
ATOM   596  C CD2 . LEU A 1 77  ? 130.279 141.311 167.380 1.00 39.26  ? 100 LEU A CD2 1 
ATOM   597  N N   . ASP A 1 78  ? 127.852 145.299 170.056 1.00 41.76  ? 101 ASP A N   1 
ATOM   598  C CA  . ASP A 1 78  ? 127.908 146.666 170.568 1.00 41.76  ? 101 ASP A CA  1 
ATOM   599  C C   . ASP A 1 78  ? 128.663 146.725 171.893 1.00 41.76  ? 101 ASP A C   1 
ATOM   600  O O   . ASP A 1 78  ? 129.504 147.611 172.103 1.00 41.76  ? 101 ASP A O   1 
ATOM   601  C CB  . ASP A 1 78  ? 126.491 147.221 170.726 1.00 41.76  ? 101 ASP A CB  1 
ATOM   602  C CG  . ASP A 1 78  ? 126.473 148.692 171.097 1.00 41.76  ? 101 ASP A CG  1 
ATOM   603  O OD1 . ASP A 1 78  ? 127.540 149.340 171.059 1.00 41.76  ? 101 ASP A OD1 1 
ATOM   604  O OD2 . ASP A 1 78  ? 125.382 149.205 171.422 1.00 41.76  ? 101 ASP A OD2 1 
ATOM   605  N N   . ARG A 1 79  ? 128.379 145.785 172.798 1.00 39.46  ? 102 ARG A N   1 
ATOM   606  C CA  . ARG A 1 79  ? 129.091 145.757 174.074 1.00 39.46  ? 102 ARG A CA  1 
ATOM   607  C C   . ARG A 1 79  ? 130.583 145.510 173.873 1.00 39.46  ? 102 ARG A C   1 
ATOM   608  O O   . ARG A 1 79  ? 131.420 146.113 174.558 1.00 39.46  ? 102 ARG A O   1 
ATOM   609  C CB  . ARG A 1 79  ? 128.493 144.693 174.994 1.00 39.46  ? 102 ARG A CB  1 
ATOM   610  C CG  . ARG A 1 79  ? 127.080 144.997 175.465 1.00 39.46  ? 102 ARG A CG  1 
ATOM   611  C CD  . ARG A 1 79  ? 126.789 144.356 176.816 1.00 39.46  ? 102 ARG A CD  1 
ATOM   612  N NE  . ARG A 1 79  ? 126.864 142.897 176.774 1.00 39.46  ? 102 ARG A NE  1 
ATOM   613  C CZ  . ARG A 1 79  ? 127.882 142.186 177.249 1.00 39.46  ? 102 ARG A CZ  1 
ATOM   614  N NH1 . ARG A 1 79  ? 128.920 142.797 177.802 1.00 39.46  ? 102 ARG A NH1 1 
ATOM   615  N NH2 . ARG A 1 79  ? 127.864 140.863 177.169 1.00 39.46  ? 102 ARG A NH2 1 
ATOM   616  N N   . VAL A 1 80  ? 130.935 144.626 172.936 1.00 36.30  ? 103 VAL A N   1 
ATOM   617  C CA  . VAL A 1 80  ? 132.344 144.353 172.669 1.00 36.30  ? 103 VAL A CA  1 
ATOM   618  C C   . VAL A 1 80  ? 133.034 145.593 172.114 1.00 36.30  ? 103 VAL A C   1 
ATOM   619  O O   . VAL A 1 80  ? 134.178 145.898 172.476 1.00 36.30  ? 103 VAL A O   1 
ATOM   620  C CB  . VAL A 1 80  ? 132.484 143.149 171.721 1.00 36.30  ? 103 VAL A CB  1 
ATOM   621  C CG1 . VAL A 1 80  ? 133.911 143.032 171.218 1.00 36.30  ? 103 VAL A CG1 1 
ATOM   622  C CG2 . VAL A 1 80  ? 132.066 141.871 172.426 1.00 36.30  ? 103 VAL A CG2 1 
ATOM   623  N N   . LEU A 1 81  ? 132.355 146.328 171.230 1.00 37.56  ? 104 LEU A N   1 
ATOM   624  C CA  . LEU A 1 81  ? 132.916 147.574 170.719 1.00 37.56  ? 104 LEU A CA  1 
ATOM   625  C C   . LEU A 1 81  ? 133.146 148.576 171.843 1.00 37.56  ? 104 LEU A C   1 
ATOM   626  O O   . LEU A 1 81  ? 134.186 149.245 171.887 1.00 37.56  ? 104 LEU A O   1 
ATOM   627  C CB  . LEU A 1 81  ? 131.995 148.170 169.656 1.00 37.56  ? 104 LEU A CB  1 
ATOM   628  C CG  . LEU A 1 81  ? 132.172 147.654 168.229 1.00 37.56  ? 104 LEU A CG  1 
ATOM   629  C CD1 . LEU A 1 81  ? 131.130 148.270 167.313 1.00 37.56  ? 104 LEU A CD1 1 
ATOM   630  C CD2 . LEU A 1 81  ? 133.575 147.950 167.726 1.00 37.56  ? 104 LEU A CD2 1 
ATOM   631  N N   . TYR A 1 82  ? 132.184 148.694 172.762 1.00 37.93  ? 105 TYR A N   1 
ATOM   632  C CA  . TYR A 1 82  ? 132.351 149.611 173.887 1.00 37.93  ? 105 TYR A CA  1 
ATOM   633  C C   . TYR A 1 82  ? 133.545 149.217 174.753 1.00 37.93  ? 105 TYR A C   1 
ATOM   634  O O   . TYR A 1 82  ? 134.343 150.075 175.157 1.00 37.93  ? 105 TYR A O   1 
ATOM   635  C CB  . TYR A 1 82  ? 131.071 149.656 174.721 1.00 37.93  ? 105 TYR A CB  1 
ATOM   636  C CG  . TYR A 1 82  ? 131.168 150.529 175.951 1.00 37.93  ? 105 TYR A CG  1 
ATOM   637  C CD1 . TYR A 1 82  ? 131.336 149.971 177.211 1.00 37.93  ? 105 TYR A CD1 1 
ATOM   638  C CD2 . TYR A 1 82  ? 131.090 151.912 175.853 1.00 37.93  ? 105 TYR A CD2 1 
ATOM   639  C CE1 . TYR A 1 82  ? 131.425 150.765 178.339 1.00 37.93  ? 105 TYR A CE1 1 
ATOM   640  C CE2 . TYR A 1 82  ? 131.178 152.714 176.975 1.00 37.93  ? 105 TYR A CE2 1 
ATOM   641  C CZ  . TYR A 1 82  ? 131.345 152.135 178.215 1.00 37.93  ? 105 TYR A CZ  1 
ATOM   642  O OH  . TYR A 1 82  ? 131.433 152.928 179.335 1.00 37.93  ? 105 TYR A OH  1 
ATOM   643  N N   . GLN A 1 83  ? 133.685 147.922 175.045 1.00 37.14  ? 106 GLN A N   1 
ATOM   644  C CA  . GLN A 1 83  ? 134.801 147.472 175.873 1.00 37.14  ? 106 GLN A CA  1 
ATOM   645  C C   . GLN A 1 83  ? 136.139 147.694 175.176 1.00 37.14  ? 106 GLN A C   1 
ATOM   646  O O   . GLN A 1 83  ? 137.126 148.072 175.820 1.00 37.14  ? 106 GLN A O   1 
ATOM   647  C CB  . GLN A 1 83  ? 134.625 145.999 176.240 1.00 37.14  ? 106 GLN A CB  1 
ATOM   648  C CG  . GLN A 1 83  ? 133.425 145.718 177.129 1.00 37.14  ? 106 GLN A CG  1 
ATOM   649  C CD  . GLN A 1 83  ? 133.609 146.231 178.542 1.00 37.14  ? 106 GLN A CD  1 
ATOM   650  O OE1 . GLN A 1 83  ? 134.729 146.493 178.980 1.00 37.14  ? 106 GLN A OE1 1 
ATOM   651  N NE2 . GLN A 1 83  ? 132.506 146.377 179.266 1.00 37.14  ? 106 GLN A NE2 1 
ATOM   652  N N   . LEU A 1 84  ? 136.194 147.470 173.860 1.00 38.39  ? 107 LEU A N   1 
ATOM   653  C CA  . LEU A 1 84  ? 137.433 147.717 173.129 1.00 38.39  ? 107 LEU A CA  1 
ATOM   654  C C   . LEU A 1 84  ? 137.774 149.201 173.113 1.00 38.39  ? 107 LEU A C   1 
ATOM   655  O O   . LEU A 1 84  ? 138.948 149.574 173.209 1.00 38.39  ? 107 LEU A O   1 
ATOM   656  C CB  . LEU A 1 84  ? 137.325 147.177 171.704 1.00 38.39  ? 107 LEU A CB  1 
ATOM   657  C CG  . LEU A 1 84  ? 137.388 145.657 171.543 1.00 38.39  ? 107 LEU A CG  1 
ATOM   658  C CD1 . LEU A 1 84  ? 137.381 145.277 170.072 1.00 38.39  ? 107 LEU A CD1 1 
ATOM   659  C CD2 . LEU A 1 84  ? 138.613 145.090 172.242 1.00 38.39  ? 107 LEU A CD2 1 
ATOM   660  N N   . ASP A 1 85  ? 136.760 150.063 172.995 1.00 41.19  ? 108 ASP A N   1 
ATOM   661  C CA  . ASP A 1 85  ? 137.006 151.500 173.063 1.00 41.19  ? 108 ASP A CA  1 
ATOM   662  C C   . ASP A 1 85  ? 137.557 151.892 174.428 1.00 41.19  ? 108 ASP A C   1 
ATOM   663  O O   . ASP A 1 85  ? 138.476 152.714 174.523 1.00 41.19  ? 108 ASP A O   1 
ATOM   664  C CB  . ASP A 1 85  ? 135.716 152.263 172.758 1.00 41.19  ? 108 ASP A CB  1 
ATOM   665  C CG  . ASP A 1 85  ? 135.927 153.763 172.655 1.00 41.19  ? 108 ASP A CG  1 
ATOM   666  O OD1 . ASP A 1 85  ? 137.092 154.212 172.631 1.00 41.19  ? 108 ASP A OD1 1 
ATOM   667  O OD2 . ASP A 1 85  ? 134.918 154.496 172.592 1.00 41.19  ? 108 ASP A OD2 1 
ATOM   668  N N   . ALA A 1 86  ? 137.012 151.306 175.497 1.00 40.22  ? 109 ALA A N   1 
ATOM   669  C CA  . ALA A 1 86  ? 137.529 151.590 176.833 1.00 40.22  ? 109 ALA A CA  1 
ATOM   670  C C   . ALA A 1 86  ? 138.975 151.127 176.979 1.00 40.22  ? 109 ALA A C   1 
ATOM   671  O O   . ALA A 1 86  ? 139.812 151.840 177.548 1.00 40.22  ? 109 ALA A O   1 
ATOM   672  C CB  . ALA A 1 86  ? 136.644 150.932 177.891 1.00 40.22  ? 109 ALA A CB  1 
ATOM   673  N N   . LEU A 1 87  ? 139.290 149.933 176.471 1.00 39.95  ? 110 LEU A N   1 
ATOM   674  C CA  . LEU A 1 87  ? 140.662 149.438 176.548 1.00 39.95  ? 110 LEU A CA  1 
ATOM   675  C C   . LEU A 1 87  ? 141.616 150.327 175.760 1.00 39.95  ? 110 LEU A C   1 
ATOM   676  O O   . LEU A 1 87  ? 142.748 150.577 176.193 1.00 39.95  ? 110 LEU A O   1 
ATOM   677  C CB  . LEU A 1 87  ? 140.732 147.997 176.044 1.00 39.95  ? 110 LEU A CB  1 
ATOM   678  C CG  . LEU A 1 87  ? 142.127 147.369 175.991 1.00 39.95  ? 110 LEU A CG  1 
ATOM   679  C CD1 . LEU A 1 87  ? 142.772 147.378 177.367 1.00 39.95  ? 110 LEU A CD1 1 
ATOM   680  C CD2 . LEU A 1 87  ? 142.063 145.956 175.434 1.00 39.95  ? 110 LEU A CD2 1 
ATOM   681  N N   . ARG A 1 88  ? 141.178 150.813 174.597 1.00 43.77  ? 111 ARG A N   1 
ATOM   682  C CA  . ARG A 1 88  ? 142.009 151.720 173.814 1.00 43.77  ? 111 ARG A CA  1 
ATOM   683  C C   . ARG A 1 88  ? 142.234 153.035 174.549 1.00 43.77  ? 111 ARG A C   1 
ATOM   684  O O   . ARG A 1 88  ? 143.352 153.562 174.563 1.00 43.77  ? 111 ARG A O   1 
ATOM   685  C CB  . ARG A 1 88  ? 141.368 151.973 172.450 1.00 43.77  ? 111 ARG A CB  1 
ATOM   686  C CG  . ARG A 1 88  ? 142.194 152.850 171.526 1.00 43.77  ? 111 ARG A CG  1 
ATOM   687  C CD  . ARG A 1 88  ? 141.560 152.940 170.149 1.00 43.77  ? 111 ARG A CD  1 
ATOM   688  N NE  . ARG A 1 88  ? 142.370 153.724 169.222 1.00 43.77  ? 111 ARG A NE  1 
ATOM   689  C CZ  . ARG A 1 88  ? 142.086 153.882 167.934 1.00 43.77  ? 111 ARG A CZ  1 
ATOM   690  N NH1 . ARG A 1 88  ? 142.878 154.614 167.162 1.00 43.77  ? 111 ARG A NH1 1 
ATOM   691  N NH2 . ARG A 1 88  ? 141.008 153.309 167.416 1.00 43.77  ? 111 ARG A NH2 1 
ATOM   692  N N   . GLN A 1 89  ? 141.183 153.579 175.167 1.00 47.16  ? 112 GLN A N   1 
ATOM   693  C CA  . GLN A 1 89  ? 141.314 154.823 175.914 1.00 47.16  ? 112 GLN A CA  1 
ATOM   694  C C   . GLN A 1 89  ? 142.071 154.651 177.223 1.00 47.16  ? 112 GLN A C   1 
ATOM   695  O O   . GLN A 1 89  ? 142.446 155.656 177.834 1.00 47.16  ? 112 GLN A O   1 
ATOM   696  C CB  . GLN A 1 89  ? 139.932 155.417 176.190 1.00 47.16  ? 112 GLN A CB  1 
ATOM   697  C CG  . GLN A 1 89  ? 139.396 156.279 175.060 1.00 47.16  ? 112 GLN A CG  1 
ATOM   698  C CD  . GLN A 1 89  ? 140.160 157.579 174.905 1.00 47.16  ? 112 GLN A CD  1 
ATOM   699  O OE1 . GLN A 1 89  ? 140.793 158.056 175.847 1.00 47.16  ? 112 GLN A OE1 1 
ATOM   700  N NE2 . GLN A 1 89  ? 140.108 158.157 173.711 1.00 47.16  ? 112 GLN A NE2 1 
ATOM   701  N N   . LYS A 1 90  ? 142.278 153.417 177.681 1.00 45.78  ? 113 LYS A N   1 
ATOM   702  C CA  . LYS A 1 90  ? 143.088 153.175 178.869 1.00 45.78  ? 113 LYS A CA  1 
ATOM   703  C C   . LYS A 1 90  ? 144.543 152.845 178.560 1.00 45.78  ? 113 LYS A C   1 
ATOM   704  O O   . LYS A 1 90  ? 145.417 153.142 179.380 1.00 45.78  ? 113 LYS A O   1 
ATOM   705  C CB  . LYS A 1 90  ? 142.490 152.034 179.700 1.00 45.78  ? 113 LYS A CB  1 
ATOM   706  C CG  . LYS A 1 90  ? 141.319 152.447 180.572 1.00 45.78  ? 113 LYS A CG  1 
ATOM   707  C CD  . LYS A 1 90  ? 140.888 151.309 181.478 1.00 45.78  ? 113 LYS A CD  1 
ATOM   708  C CE  . LYS A 1 90  ? 139.803 151.753 182.443 1.00 45.78  ? 113 LYS A CE  1 
ATOM   709  N NZ  . LYS A 1 90  ? 139.399 150.653 183.360 1.00 45.78  ? 113 LYS A NZ  1 
ATOM   710  N N   . PHE A 1 91  ? 144.827 152.236 177.406 1.00 46.61  ? 114 PHE A N   1 
ATOM   711  C CA  . PHE A 1 91  ? 146.194 151.817 177.109 1.00 46.61  ? 114 PHE A CA  1 
ATOM   712  C C   . PHE A 1 91  ? 147.088 152.994 176.730 1.00 46.61  ? 114 PHE A C   1 
ATOM   713  O O   . PHE A 1 91  ? 148.253 153.042 177.138 1.00 46.61  ? 114 PHE A O   1 
ATOM   714  C CB  . PHE A 1 91  ? 146.187 150.770 175.994 1.00 46.61  ? 114 PHE A CB  1 
ATOM   715  C CG  . PHE A 1 91  ? 147.513 150.100 175.781 1.00 46.61  ? 114 PHE A CG  1 
ATOM   716  C CD1 . PHE A 1 91  ? 148.079 149.324 176.777 1.00 46.61  ? 114 PHE A CD1 1 
ATOM   717  C CD2 . PHE A 1 91  ? 148.187 150.233 174.580 1.00 46.61  ? 114 PHE A CD2 1 
ATOM   718  C CE1 . PHE A 1 91  ? 149.297 148.703 176.582 1.00 46.61  ? 114 PHE A CE1 1 
ATOM   719  C CE2 . PHE A 1 91  ? 149.404 149.613 174.380 1.00 46.61  ? 114 PHE A CE2 1 
ATOM   720  C CZ  . PHE A 1 91  ? 149.959 148.846 175.382 1.00 46.61  ? 114 PHE A CZ  1 
ATOM   721  N N   . LEU A 1 92  ? 146.566 153.936 175.940 1.00 50.63  ? 115 LEU A N   1 
ATOM   722  C CA  . LEU A 1 92  ? 147.290 155.151 175.548 1.00 50.63  ? 115 LEU A CA  1 
ATOM   723  C C   . LEU A 1 92  ? 148.539 154.841 174.724 1.00 50.63  ? 115 LEU A C   1 
ATOM   724  O O   . LEU A 1 92  ? 149.596 155.443 174.921 1.00 50.63  ? 115 LEU A O   1 
ATOM   725  C CB  . LEU A 1 92  ? 147.653 156.007 176.764 1.00 50.63  ? 115 LEU A CB  1 
ATOM   726  C CG  . LEU A 1 92  ? 146.724 157.182 177.067 1.00 50.63  ? 115 LEU A CG  1 
ATOM   727  C CD1 . LEU A 1 92  ? 146.606 158.092 175.856 1.00 50.63  ? 115 LEU A CD1 1 
ATOM   728  C CD2 . LEU A 1 92  ? 145.365 156.675 177.488 1.00 50.63  ? 115 LEU A CD2 1 
ATOM   729  N N   . LYS A 1 93  ? 148.421 153.894 173.792 1.00 54.53  ? 116 LYS A N   1 
ATOM   730  C CA  . LYS A 1 93  ? 149.476 153.681 172.801 1.00 54.53  ? 116 LYS A CA  1 
ATOM   731  C C   . LYS A 1 93  ? 148.840 153.020 171.579 1.00 54.53  ? 116 LYS A C   1 
ATOM   732  O O   . LYS A 1 93  ? 148.601 151.810 171.583 1.00 54.53  ? 116 LYS A O   1 
ATOM   733  C CB  . LYS A 1 93  ? 150.613 152.845 173.364 1.00 54.53  ? 116 LYS A CB  1 
ATOM   734  C CG  . LYS A 1 93  ? 151.949 153.569 173.351 1.00 54.53  ? 116 LYS A CG  1 
ATOM   735  C CD  . LYS A 1 93  ? 153.099 152.649 173.718 1.00 54.53  ? 116 LYS A CD  1 
ATOM   736  C CE  . LYS A 1 93  ? 154.421 153.399 173.695 1.00 54.53  ? 116 LYS A CE  1 
ATOM   737  N NZ  . LYS A 1 93  ? 155.574 152.512 174.014 1.00 54.53  ? 116 LYS A NZ  1 
ATOM   738  N N   . THR A 1 94  ? 148.573 153.822 170.552 1.00 61.57  ? 117 THR A N   1 
ATOM   739  C CA  . THR A 1 94  ? 147.989 153.337 169.307 1.00 61.57  ? 117 THR A CA  1 
ATOM   740  C C   . THR A 1 94  ? 149.009 152.699 168.360 1.00 61.57  ? 117 THR A C   1 
ATOM   741  O O   . THR A 1 94  ? 148.699 151.658 167.766 1.00 61.57  ? 117 THR A O   1 
ATOM   742  C CB  . THR A 1 94  ? 147.240 154.469 168.593 1.00 61.57  ? 117 THR A CB  1 
ATOM   743  O OG1 . THR A 1 94  ? 148.153 155.269 167.833 1.00 61.57  ? 117 THR A OG1 1 
ATOM   744  C CG2 . THR A 1 94  ? 146.524 155.352 169.605 1.00 61.57  ? 117 THR A CG2 1 
ATOM   745  N N   . PRO A 1 95  ? 150.215 153.259 168.169 1.00 61.70  ? 118 PRO A N   1 
ATOM   746  C CA  . PRO A 1 95  ? 151.102 152.684 167.142 1.00 61.70  ? 118 PRO A CA  1 
ATOM   747  C C   . PRO A 1 95  ? 151.628 151.306 167.497 1.00 61.70  ? 118 PRO A C   1 
ATOM   748  O O   . PRO A 1 95  ? 151.956 150.531 166.590 1.00 61.70  ? 118 PRO A O   1 
ATOM   749  C CB  . PRO A 1 95  ? 152.243 153.709 167.038 1.00 61.70  ? 118 PRO A CB  1 
ATOM   750  C CG  . PRO A 1 95  ? 151.771 154.918 167.778 1.00 61.70  ? 118 PRO A CG  1 
ATOM   751  C CD  . PRO A 1 95  ? 150.878 154.390 168.841 1.00 61.70  ? 118 PRO A CD  1 
ATOM   752  N N   . ALA A 1 96  ? 151.722 150.973 168.781 1.00 56.94  ? 119 ALA A N   1 
ATOM   753  C CA  . ALA A 1 96  ? 152.243 149.682 169.206 1.00 56.94  ? 119 ALA A CA  1 
ATOM   754  C C   . ALA A 1 96  ? 151.183 148.587 169.232 1.00 56.94  ? 119 ALA A C   1 
ATOM   755  O O   . ALA A 1 96  ? 151.439 147.518 169.797 1.00 56.94  ? 119 ALA A O   1 
ATOM   756  C CB  . ALA A 1 96  ? 152.892 149.805 170.587 1.00 56.94  ? 119 ALA A CB  1 
ATOM   757  N N   . PHE A 1 97  ? 150.011 148.818 168.640 1.00 51.51  ? 120 PHE A N   1 
ATOM   758  C CA  . PHE A 1 97  ? 148.946 147.824 168.685 1.00 51.51  ? 120 PHE A CA  1 
ATOM   759  C C   . PHE A 1 97  ? 147.928 148.065 167.575 1.00 51.51  ? 120 PHE A C   1 
ATOM   760  O O   . PHE A 1 97  ? 146.846 148.607 167.833 1.00 51.51  ? 120 PHE A O   1 
ATOM   761  C CB  . PHE A 1 97  ? 148.265 147.849 170.055 1.00 51.51  ? 120 PHE A CB  1 
ATOM   762  C CG  . PHE A 1 97  ? 147.603 146.555 170.429 1.00 51.51  ? 120 PHE A CG  1 
ATOM   763  C CD1 . PHE A 1 97  ? 148.315 145.369 170.419 1.00 51.51  ? 120 PHE A CD1 1 
ATOM   764  C CD2 . PHE A 1 97  ? 146.272 146.527 170.809 1.00 51.51  ? 120 PHE A CD2 1 
ATOM   765  C CE1 . PHE A 1 97  ? 147.710 144.177 170.767 1.00 51.51  ? 120 PHE A CE1 1 
ATOM   766  C CE2 . PHE A 1 97  ? 145.661 145.338 171.159 1.00 51.51  ? 120 PHE A CE2 1 
ATOM   767  C CZ  . PHE A 1 97  ? 146.381 144.163 171.138 1.00 51.51  ? 120 PHE A CZ  1 
ATOM   768  N N   . PRO A 1 98  ? 148.233 147.683 166.330 1.00 51.57  ? 121 PRO A N   1 
ATOM   769  C CA  . PRO A 1 98  ? 147.251 147.835 165.246 1.00 51.57  ? 121 PRO A CA  1 
ATOM   770  C C   . PRO A 1 98  ? 146.209 146.729 165.196 1.00 51.57  ? 121 PRO A C   1 
ATOM   771  O O   . PRO A 1 98  ? 145.181 146.897 164.520 1.00 51.57  ? 121 PRO A O   1 
ATOM   772  C CB  . PRO A 1 98  ? 148.127 147.817 163.989 1.00 51.57  ? 121 PRO A CB  1 
ATOM   773  C CG  . PRO A 1 98  ? 149.276 146.942 164.367 1.00 51.57  ? 121 PRO A CG  1 
ATOM   774  C CD  . PRO A 1 98  ? 149.524 147.168 165.840 1.00 51.57  ? 121 PRO A CD  1 
ATOM   775  N N   . LYS A 1 99  ? 146.446 145.607 165.883 1.00 48.21  ? 122 LYS A N   1 
ATOM   776  C CA  . LYS A 1 99  ? 145.454 144.540 165.928 1.00 48.21  ? 122 LYS A CA  1 
ATOM   777  C C   . LYS A 1 99  ? 144.140 145.029 166.518 1.00 48.21  ? 122 LYS A C   1 
ATOM   778  O O   . LYS A 1 99  ? 143.072 144.529 166.149 1.00 48.21  ? 122 LYS A O   1 
ATOM   779  C CB  . LYS A 1 99  ? 145.991 143.358 166.734 1.00 48.21  ? 122 LYS A CB  1 
ATOM   780  C CG  . LYS A 1 99  ? 147.222 142.702 166.134 1.00 48.21  ? 122 LYS A CG  1 
ATOM   781  C CD  . LYS A 1 99  ? 146.910 142.066 164.790 1.00 48.21  ? 122 LYS A CD  1 
ATOM   782  C CE  . LYS A 1 99  ? 148.116 141.325 164.238 1.00 48.21  ? 122 LYS A CE  1 
ATOM   783  N NZ  . LYS A 1 99  ? 147.816 140.665 162.938 1.00 48.21  ? 122 LYS A NZ  1 
ATOM   784  N N   . LEU A 1 100 ? 144.196 146.012 167.418 1.00 47.60  ? 123 LEU A N   1 
ATOM   785  C CA  . LEU A 1 100 ? 142.974 146.580 167.975 1.00 47.60  ? 123 LEU A CA  1 
ATOM   786  C C   . LEU A 1 100 ? 142.139 147.249 166.889 1.00 47.60  ? 123 LEU A C   1 
ATOM   787  O O   . LEU A 1 100 ? 140.927 147.025 166.795 1.00 47.60  ? 123 LEU A O   1 
ATOM   788  C CB  . LEU A 1 100 ? 143.323 147.574 169.082 1.00 47.60  ? 123 LEU A CB  1 
ATOM   789  C CG  . LEU A 1 100 ? 142.176 148.056 169.968 1.00 47.60  ? 123 LEU A CG  1 
ATOM   790  C CD1 . LEU A 1 100 ? 141.362 146.879 170.472 1.00 47.60  ? 123 LEU A CD1 1 
ATOM   791  C CD2 . LEU A 1 100 ? 142.720 148.866 171.129 1.00 47.60  ? 123 LEU A CD2 1 
ATOM   792  N N   . ASP A 1 101 ? 142.778 148.067 166.049 1.00 48.33  ? 124 ASP A N   1 
ATOM   793  C CA  . ASP A 1 101 ? 142.058 148.718 164.959 1.00 48.33  ? 124 ASP A CA  1 
ATOM   794  C C   . ASP A 1 101 ? 141.550 147.699 163.947 1.00 48.33  ? 124 ASP A C   1 
ATOM   795  O O   . ASP A 1 101 ? 140.438 147.836 163.419 1.00 48.33  ? 124 ASP A O   1 
ATOM   796  C CB  . ASP A 1 101 ? 142.957 149.748 164.277 1.00 48.33  ? 124 ASP A CB  1 
ATOM   797  C CG  . ASP A 1 101 ? 143.090 151.025 165.079 1.00 48.33  ? 124 ASP A CG  1 
ATOM   798  O OD1 . ASP A 1 101 ? 142.062 151.701 165.296 1.00 48.33  ? 124 ASP A OD1 1 
ATOM   799  O OD2 . ASP A 1 101 ? 144.221 151.354 165.494 1.00 48.33  ? 124 ASP A OD2 1 
ATOM   800  N N   . SER A 1 102 ? 142.352 146.670 163.660 1.00 45.74  ? 125 SER A N   1 
ATOM   801  C CA  . SER A 1 102 ? 141.909 145.630 162.735 1.00 45.74  ? 125 SER A CA  1 
ATOM   802  C C   . SER A 1 102 ? 140.662 144.925 163.259 1.00 45.74  ? 125 SER A C   1 
ATOM   803  O O   . SER A 1 102 ? 139.685 144.729 162.524 1.00 45.74  ? 125 SER A O   1 
ATOM   804  C CB  . SER A 1 102 ? 143.037 144.628 162.495 1.00 45.74  ? 125 SER A CB  1 
ATOM   805  O OG  . SER A 1 102 ? 144.029 145.175 161.644 1.00 45.74  ? 125 SER A OG  1 
ATOM   806  N N   . ALA A 1 103 ? 140.676 144.544 164.539 1.00 44.56  ? 126 ALA A N   1 
ATOM   807  C CA  . ALA A 1 103 ? 139.520 143.880 165.130 1.00 44.56  ? 126 ALA A CA  1 
ATOM   808  C C   . ALA A 1 103 ? 138.314 144.808 165.177 1.00 44.56  ? 126 ALA A C   1 
ATOM   809  O O   . ALA A 1 103 ? 137.178 144.363 164.984 1.00 44.56  ? 126 ALA A O   1 
ATOM   810  C CB  . ALA A 1 103 ? 139.864 143.375 166.530 1.00 44.56  ? 126 ALA A CB  1 
ATOM   811  N N   . ARG A 1 104 ? 138.539 146.101 165.421 1.00 43.41  ? 127 ARG A N   1 
ATOM   812  C CA  . ARG A 1 104 ? 137.429 147.048 165.433 1.00 43.41  ? 127 ARG A CA  1 
ATOM   813  C C   . ARG A 1 104 ? 136.780 147.152 164.059 1.00 43.41  ? 127 ARG A C   1 
ATOM   814  O O   . ARG A 1 104 ? 135.547 147.148 163.942 1.00 43.41  ? 127 ARG A O   1 
ATOM   815  C CB  . ARG A 1 104 ? 137.915 148.418 165.904 1.00 43.41  ? 127 ARG A CB  1 
ATOM   816  C CG  . ARG A 1 104 ? 136.801 149.414 166.155 1.00 43.41  ? 127 ARG A CG  1 
ATOM   817  C CD  . ARG A 1 104 ? 137.334 150.689 166.782 1.00 43.41  ? 127 ARG A CD  1 
ATOM   818  N NE  . ARG A 1 104 ? 136.263 151.637 167.071 1.00 43.41  ? 127 ARG A NE  1 
ATOM   819  C CZ  . ARG A 1 104 ? 135.827 152.552 166.213 1.00 43.41  ? 127 ARG A CZ  1 
ATOM   820  N NH1 . ARG A 1 104 ? 134.846 153.375 166.559 1.00 43.41  ? 127 ARG A NH1 1 
ATOM   821  N NH2 . ARG A 1 104 ? 136.371 152.645 165.007 1.00 43.41  ? 127 ARG A NH2 1 
ATOM   822  N N   . HIS A 1 105 ? 137.594 147.240 163.005 1.00 43.52  ? 128 HIS A N   1 
ATOM   823  C CA  . HIS A 1 105 ? 137.041 147.298 161.655 1.00 43.52  ? 128 HIS A CA  1 
ATOM   824  C C   . HIS A 1 105 ? 136.307 146.010 161.305 1.00 43.52  ? 128 HIS A C   1 
ATOM   825  O O   . HIS A 1 105 ? 135.244 146.044 160.671 1.00 43.52  ? 128 HIS A O   1 
ATOM   826  C CB  . HIS A 1 105 ? 138.151 147.579 160.643 1.00 43.52  ? 128 HIS A CB  1 
ATOM   827  C CG  . HIS A 1 105 ? 138.537 149.022 160.557 1.00 43.52  ? 128 HIS A CG  1 
ATOM   828  N ND1 . HIS A 1 105 ? 137.765 149.961 159.909 1.00 43.52  ? 128 HIS A ND1 1 
ATOM   829  C CD2 . HIS A 1 105 ? 139.616 149.686 161.035 1.00 43.52  ? 128 HIS A CD2 1 
ATOM   830  C CE1 . HIS A 1 105 ? 138.350 151.143 159.993 1.00 43.52  ? 128 HIS A CE1 1 
ATOM   831  N NE2 . HIS A 1 105 ? 139.474 151.003 160.672 1.00 43.52  ? 128 HIS A NE2 1 
ATOM   832  N N   . ASN A 1 106 ? 136.853 144.862 161.716 1.00 41.54  ? 129 ASN A N   1 
ATOM   833  C CA  . ASN A 1 106 ? 136.180 143.594 161.445 1.00 41.54  ? 129 ASN A CA  1 
ATOM   834  C C   . ASN A 1 106 ? 134.837 143.514 162.164 1.00 41.54  ? 129 ASN A C   1 
ATOM   835  O O   . ASN A 1 106 ? 133.849 143.031 161.598 1.00 41.54  ? 129 ASN A O   1 
ATOM   836  C CB  . ASN A 1 106 ? 137.080 142.428 161.849 1.00 41.54  ? 129 ASN A CB  1 
ATOM   837  C CG  . ASN A 1 106 ? 138.305 142.309 160.967 1.00 41.54  ? 129 ASN A CG  1 
ATOM   838  O OD1 . ASN A 1 106 ? 138.627 143.220 160.205 1.00 41.54  ? 129 ASN A OD1 1 
ATOM   839  N ND2 . ASN A 1 106 ? 139.000 141.182 161.068 1.00 41.54  ? 129 ASN A ND2 1 
ATOM   840  N N   . ILE A 1 107 ? 134.780 143.987 163.410 1.00 38.51  ? 130 ILE A N   1 
ATOM   841  C CA  . ILE A 1 107 ? 133.525 143.964 164.155 1.00 38.51  ? 130 ILE A CA  1 
ATOM   842  C C   . ILE A 1 107 ? 132.511 144.908 163.522 1.00 38.51  ? 130 ILE A C   1 
ATOM   843  O O   . ILE A 1 107 ? 131.317 144.594 163.442 1.00 38.51  ? 130 ILE A O   1 
ATOM   844  C CB  . ILE A 1 107 ? 133.775 144.304 165.635 1.00 38.51  ? 130 ILE A CB  1 
ATOM   845  C CG1 . ILE A 1 107 ? 134.579 143.191 166.306 1.00 38.51  ? 130 ILE A CG1 1 
ATOM   846  C CG2 . ILE A 1 107 ? 132.462 144.506 166.367 1.00 38.51  ? 130 ILE A CG2 1 
ATOM   847  C CD1 . ILE A 1 107 ? 134.964 143.498 167.733 1.00 38.51  ? 130 ILE A CD1 1 
ATOM   848  N N   . LEU A 1 108 ? 132.965 146.074 163.054 1.00 38.84  ? 131 LEU A N   1 
ATOM   849  C CA  . LEU A 1 108 ? 132.060 146.984 162.358 1.00 38.84  ? 131 LEU A CA  1 
ATOM   850  C C   . LEU A 1 108 ? 131.512 146.348 161.085 1.00 38.84  ? 131 LEU A C   1 
ATOM   851  O O   . LEU A 1 108 ? 130.324 146.494 160.768 1.00 38.84  ? 131 LEU A O   1 
ATOM   852  C CB  . LEU A 1 108 ? 132.777 148.296 162.039 1.00 38.84  ? 131 LEU A CB  1 
ATOM   853  C CG  . LEU A 1 108 ? 133.055 149.223 163.222 1.00 38.84  ? 131 LEU A CG  1 
ATOM   854  C CD1 . LEU A 1 108 ? 133.839 150.443 162.773 1.00 38.84  ? 131 LEU A CD1 1 
ATOM   855  C CD2 . LEU A 1 108 ? 131.756 149.636 163.890 1.00 38.84  ? 131 LEU A CD2 1 
ATOM   856  N N   . GLY A 1 109 ? 132.364 145.635 160.345 1.00 37.47  ? 132 GLY A N   1 
ATOM   857  C CA  . GLY A 1 109 ? 131.891 144.945 159.156 1.00 37.47  ? 132 GLY A CA  1 
ATOM   858  C C   . GLY A 1 109 ? 130.871 143.867 159.472 1.00 37.47  ? 132 GLY A C   1 
ATOM   859  O O   . GLY A 1 109 ? 129.862 143.729 158.775 1.00 37.47  ? 132 GLY A O   1 
ATOM   860  N N   . ILE A 1 110 ? 131.122 143.086 160.525 1.00 37.01  ? 133 ILE A N   1 
ATOM   861  C CA  . ILE A 1 110 ? 130.170 142.051 160.926 1.00 37.01  ? 133 ILE A CA  1 
ATOM   862  C C   . ILE A 1 110 ? 128.846 142.680 161.341 1.00 37.01  ? 133 ILE A C   1 
ATOM   863  O O   . ILE A 1 110 ? 127.767 142.151 161.044 1.00 37.01  ? 133 ILE A O   1 
ATOM   864  C CB  . ILE A 1 110 ? 130.762 141.182 162.051 1.00 37.01  ? 133 ILE A CB  1 
ATOM   865  C CG1 . ILE A 1 110 ? 132.005 140.441 161.559 1.00 37.01  ? 133 ILE A CG1 1 
ATOM   866  C CG2 . ILE A 1 110 ? 129.732 140.187 162.556 1.00 37.01  ? 133 ILE A CG2 1 
ATOM   867  C CD1 . ILE A 1 110 ? 132.687 139.622 162.631 1.00 37.01  ? 133 ILE A CD1 1 
ATOM   868  N N   . ARG A 1 111 ? 128.907 143.823 162.028 1.00 39.25  ? 134 ARG A N   1 
ATOM   869  C CA  . ARG A 1 111 ? 127.687 144.511 162.437 1.00 39.25  ? 134 ARG A CA  1 
ATOM   870  C C   . ARG A 1 111 ? 126.899 144.999 161.228 1.00 39.25  ? 134 ARG A C   1 
ATOM   871  O O   . ARG A 1 111 ? 125.670 144.861 161.178 1.00 39.25  ? 134 ARG A O   1 
ATOM   872  C CB  . ARG A 1 111 ? 128.036 145.678 163.360 1.00 39.25  ? 134 ARG A CB  1 
ATOM   873  C CG  . ARG A 1 111 ? 127.005 145.965 164.433 1.00 39.25  ? 134 ARG A CG  1 
ATOM   874  C CD  . ARG A 1 111 ? 127.622 146.758 165.571 1.00 39.25  ? 134 ARG A CD  1 
ATOM   875  N NE  . ARG A 1 111 ? 126.652 147.070 166.615 1.00 39.25  ? 134 ARG A NE  1 
ATOM   876  C CZ  . ARG A 1 111 ? 126.071 148.256 166.760 1.00 39.25  ? 134 ARG A CZ  1 
ATOM   877  N NH1 . ARG A 1 111 ? 126.364 149.245 165.928 1.00 39.25  ? 134 ARG A NH1 1 
ATOM   878  N NH2 . ARG A 1 111 ? 125.199 148.454 167.739 1.00 39.25  ? 134 ARG A NH2 1 
ATOM   879  N N   . ASN A 1 112 ? 127.592 145.570 160.240 1.00 39.30  ? 135 ASN A N   1 
ATOM   880  C CA  . ASN A 1 112 ? 126.917 145.988 159.014 1.00 39.30  ? 135 ASN A CA  1 
ATOM   881  C C   . ASN A 1 112 ? 126.272 144.801 158.308 1.00 39.30  ? 135 ASN A C   1 
ATOM   882  O O   . ASN A 1 112 ? 125.129 144.891 157.840 1.00 39.30  ? 135 ASN A O   1 
ATOM   883  C CB  . ASN A 1 112 ? 127.908 146.690 158.086 1.00 39.30  ? 135 ASN A CB  1 
ATOM   884  C CG  . ASN A 1 112 ? 127.307 147.023 156.737 1.00 39.30  ? 135 ASN A CG  1 
ATOM   885  O OD1 . ASN A 1 112 ? 126.113 147.295 156.626 1.00 39.30  ? 135 ASN A OD1 1 
ATOM   886  N ND2 . ASN A 1 112 ? 128.135 147.003 155.700 1.00 39.30  ? 135 ASN A ND2 1 
ATOM   887  N N   . ASN A 1 113 ? 126.987 143.676 158.233 1.00 40.44  ? 136 ASN A N   1 
ATOM   888  C CA  . ASN A 1 113 ? 126.449 142.503 157.552 1.00 40.44  ? 136 ASN A CA  1 
ATOM   889  C C   . ASN A 1 113 ? 125.212 141.966 158.261 1.00 40.44  ? 136 ASN A C   1 
ATOM   890  O O   . ASN A 1 113 ? 124.222 141.610 157.611 1.00 40.44  ? 136 ASN A O   1 
ATOM   891  C CB  . ASN A 1 113 ? 127.518 141.416 157.448 1.00 40.44  ? 136 ASN A CB  1 
ATOM   892  C CG  . ASN A 1 113 ? 128.462 141.637 156.287 1.00 40.44  ? 136 ASN A CG  1 
ATOM   893  O OD1 . ASN A 1 113 ? 128.069 142.158 155.244 1.00 40.44  ? 136 ASN A OD1 1 
ATOM   894  N ND2 . ASN A 1 113 ? 129.716 141.240 156.461 1.00 40.44  ? 136 ASN A ND2 1 
ATOM   895  N N   . VAL A 1 114 ? 125.245 141.899 159.595 1.00 41.58  ? 137 VAL A N   1 
ATOM   896  C CA  . VAL A 1 114 ? 124.091 141.359 160.307 1.00 41.58  ? 137 VAL A CA  1 
ATOM   897  C C   . VAL A 1 114 ? 122.917 142.327 160.237 1.00 41.58  ? 137 VAL A C   1 
ATOM   898  O O   . VAL A 1 114 ? 121.758 141.899 160.161 1.00 41.58  ? 137 VAL A O   1 
ATOM   899  C CB  . VAL A 1 114 ? 124.453 140.994 161.762 1.00 41.58  ? 137 VAL A CB  1 
ATOM   900  C CG1 . VAL A 1 114 ? 124.888 142.214 162.547 1.00 41.58  ? 137 VAL A CG1 1 
ATOM   901  C CG2 . VAL A 1 114 ? 123.282 140.306 162.447 1.00 41.58  ? 137 VAL A CG2 1 
ATOM   902  N N   . PHE A 1 115 ? 123.181 143.638 160.222 1.00 44.05  ? 138 PHE A N   1 
ATOM   903  C CA  . PHE A 1 115 ? 122.093 144.593 160.035 1.00 44.05  ? 138 PHE A CA  1 
ATOM   904  C C   . PHE A 1 115 ? 121.449 144.428 158.665 1.00 44.05  ? 138 PHE A C   1 
ATOM   905  O O   . PHE A 1 115 ? 120.219 144.457 158.543 1.00 44.05  ? 138 PHE A O   1 
ATOM   906  C CB  . PHE A 1 115 ? 122.602 146.021 160.215 1.00 44.05  ? 138 PHE A CB  1 
ATOM   907  C CG  . PHE A 1 115 ? 121.682 147.065 159.647 1.00 44.05  ? 138 PHE A CG  1 
ATOM   908  C CD1 . PHE A 1 115 ? 122.010 147.737 158.482 1.00 44.05  ? 138 PHE A CD1 1 
ATOM   909  C CD2 . PHE A 1 115 ? 120.486 147.369 160.275 1.00 44.05  ? 138 PHE A CD2 1 
ATOM   910  C CE1 . PHE A 1 115 ? 121.164 148.694 157.956 1.00 44.05  ? 138 PHE A CE1 1 
ATOM   911  C CE2 . PHE A 1 115 ? 119.637 148.326 159.754 1.00 44.05  ? 138 PHE A CE2 1 
ATOM   912  C CZ  . PHE A 1 115 ? 119.977 148.989 158.593 1.00 44.05  ? 138 PHE A CZ  1 
ATOM   913  N N   . CYS A 1 116 ? 122.265 144.250 157.623 1.00 46.44  ? 139 CYS A N   1 
ATOM   914  C CA  . CYS A 1 116 ? 121.714 144.056 156.286 1.00 46.44  ? 139 CYS A CA  1 
ATOM   915  C C   . CYS A 1 116 ? 120.914 142.762 156.201 1.00 46.44  ? 139 CYS A C   1 
ATOM   916  O O   . CYS A 1 116 ? 119.840 142.725 155.588 1.00 46.44  ? 139 CYS A O   1 
ATOM   917  C CB  . CYS A 1 116 ? 122.838 144.061 155.253 1.00 46.44  ? 139 CYS A CB  1 
ATOM   918  S SG  . CYS A 1 116 ? 123.646 145.660 155.054 1.00 46.44  ? 139 CYS A SG  1 
ATOM   919  N N   . MET A 1 117 ? 121.422 141.690 156.815 1.00 46.06  ? 140 MET A N   1 
ATOM   920  C CA  . MET A 1 117 ? 120.699 140.422 156.811 1.00 46.06  ? 140 MET A CA  1 
ATOM   921  C C   . MET A 1 117 ? 119.370 140.541 157.546 1.00 46.06  ? 140 MET A C   1 
ATOM   922  O O   . MET A 1 117 ? 118.360 139.975 157.113 1.00 46.06  ? 140 MET A O   1 
ATOM   923  C CB  . MET A 1 117 ? 121.563 139.325 157.434 1.00 46.06  ? 140 MET A CB  1 
ATOM   924  C CG  . MET A 1 117 ? 120.849 137.996 157.621 1.00 46.06  ? 140 MET A CG  1 
ATOM   925  S SD  . MET A 1 117 ? 120.343 137.248 156.062 1.00 46.06  ? 140 MET A SD  1 
ATOM   926  C CE  . MET A 1 117 ? 121.937 136.868 155.342 1.00 46.06  ? 140 MET A CE  1 
ATOM   927  N N   . ALA A 1 118 ? 119.349 141.276 158.660 1.00 49.94  ? 141 ALA A N   1 
ATOM   928  C CA  . ALA A 1 118 ? 118.099 141.476 159.385 1.00 49.94  ? 141 ALA A CA  1 
ATOM   929  C C   . ALA A 1 118 ? 117.122 142.320 158.578 1.00 49.94  ? 141 ALA A C   1 
ATOM   930  O O   . ALA A 1 118 ? 115.909 142.089 158.623 1.00 49.94  ? 141 ALA A O   1 
ATOM   931  C CB  . ALA A 1 118 ? 118.375 142.122 160.742 1.00 49.94  ? 141 ALA A CB  1 
ATOM   932  N N   . ARG A 1 119 ? 117.632 143.309 157.839 1.00 54.48  ? 142 ARG A N   1 
ATOM   933  C CA  . ARG A 1 119 ? 116.762 144.111 156.985 1.00 54.48  ? 142 ARG A CA  1 
ATOM   934  C C   . ARG A 1 119 ? 116.195 143.291 155.834 1.00 54.48  ? 142 ARG A C   1 
ATOM   935  O O   . ARG A 1 119 ? 115.063 143.534 155.401 1.00 54.48  ? 142 ARG A O   1 
ATOM   936  C CB  . ARG A 1 119 ? 117.525 145.323 156.449 1.00 54.48  ? 142 ARG A CB  1 
ATOM   937  C CG  . ARG A 1 119 ? 116.661 146.320 155.691 1.00 54.48  ? 142 ARG A CG  1 
ATOM   938  C CD  . ARG A 1 119 ? 117.512 147.370 154.996 1.00 54.48  ? 142 ARG A CD  1 
ATOM   939  N NE  . ARG A 1 119 ? 118.257 146.815 153.870 1.00 54.48  ? 142 ARG A NE  1 
ATOM   940  C CZ  . ARG A 1 119 ? 119.068 147.521 153.089 1.00 54.48  ? 142 ARG A CZ  1 
ATOM   941  N NH1 . ARG A 1 119 ? 119.243 148.817 153.312 1.00 54.48  ? 142 ARG A NH1 1 
ATOM   942  N NH2 . ARG A 1 119 ? 119.706 146.934 152.086 1.00 54.48  ? 142 ARG A NH2 1 
ATOM   943  N N   . LEU A 1 120 ? 116.960 142.319 155.331 1.00 52.96  ? 143 LEU A N   1 
ATOM   944  C CA  . LEU A 1 120 ? 116.480 141.501 154.222 1.00 52.96  ? 143 LEU A CA  1 
ATOM   945  C C   . LEU A 1 120 ? 115.337 140.585 154.644 1.00 52.96  ? 143 LEU A C   1 
ATOM   946  O O   . LEU A 1 120 ? 114.477 140.252 153.821 1.00 52.96  ? 143 LEU A O   1 
ATOM   947  C CB  . LEU A 1 120 ? 117.631 140.680 153.642 1.00 52.96  ? 143 LEU A CB  1 
ATOM   948  C CG  . LEU A 1 120 ? 117.357 139.937 152.335 1.00 52.96  ? 143 LEU A CG  1 
ATOM   949  C CD1 . LEU A 1 120 ? 116.945 140.912 151.248 1.00 52.96  ? 143 LEU A CD1 1 
ATOM   950  C CD2 . LEU A 1 120 ? 118.578 139.141 151.910 1.00 52.96  ? 143 LEU A CD2 1 
ATOM   951  N N   . LEU A 1 121 ? 115.306 140.171 155.909 1.00 56.57  ? 144 LEU A N   1 
ATOM   952  C CA  . LEU A 1 121 ? 114.262 139.292 156.418 1.00 56.57  ? 144 LEU A CA  1 
ATOM   953  C C   . LEU A 1 121 ? 113.037 140.050 156.912 1.00 56.57  ? 144 LEU A C   1 
ATOM   954  O O   . LEU A 1 121 ? 112.183 139.451 157.575 1.00 56.57  ? 144 LEU A O   1 
ATOM   955  C CB  . LEU A 1 121 ? 114.811 138.414 157.545 1.00 56.57  ? 144 LEU A CB  1 
ATOM   956  C CG  . LEU A 1 121 ? 115.884 137.393 157.168 1.00 56.57  ? 144 LEU A CG  1 
ATOM   957  C CD1 . LEU A 1 121 ? 116.314 136.596 158.388 1.00 56.57  ? 144 LEU A CD1 1 
ATOM   958  C CD2 . LEU A 1 121 ? 115.381 136.469 156.072 1.00 56.57  ? 144 LEU A CD2 1 
ATOM   959  N N   . ASN A 1 122 ? 112.937 141.347 156.610 1.00 58.67  ? 145 ASN A N   1 
ATOM   960  C CA  . ASN A 1 122 ? 111.799 142.174 157.018 1.00 58.67  ? 145 ASN A CA  1 
ATOM   961  C C   . ASN A 1 122 ? 111.638 142.193 158.537 1.00 58.67  ? 145 ASN A C   1 
ATOM   962  O O   . ASN A 1 122 ? 110.524 142.142 159.063 1.00 58.67  ? 145 ASN A O   1 
ATOM   963  C CB  . ASN A 1 122 ? 110.507 141.714 156.339 1.00 58.67  ? 145 ASN A CB  1 
ATOM   964  C CG  . ASN A 1 122 ? 109.566 142.862 156.040 1.00 58.67  ? 145 ASN A CG  1 
ATOM   965  O OD1 . ASN A 1 122 ? 109.912 144.028 156.226 1.00 58.67  ? 145 ASN A OD1 1 
ATOM   966  N ND2 . ASN A 1 122 ? 108.366 142.537 155.572 1.00 58.67  ? 145 ASN A ND2 1 
ATOM   967  N N   . HIS A 1 123 ? 112.760 142.265 159.249 1.00 62.29  ? 146 HIS A N   1 
ATOM   968  C CA  . HIS A 1 123 ? 112.769 142.343 160.703 1.00 62.29  ? 146 HIS A CA  1 
ATOM   969  C C   . HIS A 1 123 ? 113.458 143.626 161.144 1.00 62.29  ? 146 HIS A C   1 
ATOM   970  O O   . HIS A 1 123 ? 114.455 144.044 160.548 1.00 62.29  ? 146 HIS A O   1 
ATOM   971  C CB  . HIS A 1 123 ? 113.474 141.134 161.324 1.00 62.29  ? 146 HIS A CB  1 
ATOM   972  C CG  . HIS A 1 123 ? 113.616 141.220 162.812 1.00 62.29  ? 146 HIS A CG  1 
ATOM   973  N ND1 . HIS A 1 123 ? 112.537 141.381 163.654 1.00 62.29  ? 146 HIS A ND1 1 
ATOM   974  C CD2 . HIS A 1 123 ? 114.711 141.173 163.607 1.00 62.29  ? 146 HIS A CD2 1 
ATOM   975  C CE1 . HIS A 1 123 ? 112.961 141.426 164.905 1.00 62.29  ? 146 HIS A CE1 1 
ATOM   976  N NE2 . HIS A 1 123 ? 114.276 141.302 164.904 1.00 62.29  ? 146 HIS A NE2 1 
ATOM   977  N N   . SER A 1 124 ? 112.921 144.246 162.192 1.00 63.76  ? 147 SER A N   1 
ATOM   978  C CA  . SER A 1 124 ? 113.453 145.489 162.733 1.00 63.76  ? 147 SER A CA  1 
ATOM   979  C C   . SER A 1 124 ? 114.295 145.180 163.965 1.00 63.76  ? 147 SER A C   1 
ATOM   980  O O   . SER A 1 124 ? 113.815 144.538 164.905 1.00 63.76  ? 147 SER A O   1 
ATOM   981  C CB  . SER A 1 124 ? 112.324 146.458 163.083 1.00 63.76  ? 147 SER A CB  1 
ATOM   982  O OG  . SER A 1 124 ? 111.797 146.180 164.368 1.00 63.76  ? 147 SER A OG  1 
ATOM   983  N N   . LEU A 1 125 ? 115.546 145.633 163.955 1.00 62.78  ? 148 LEU A N   1 
ATOM   984  C CA  . LEU A 1 125 ? 116.429 145.420 165.090 1.00 62.78  ? 148 LEU A CA  1 
ATOM   985  C C   . LEU A 1 125 ? 116.079 146.372 166.232 1.00 62.78  ? 148 LEU A C   1 
ATOM   986  O O   . LEU A 1 125 ? 115.479 147.432 166.035 1.00 62.78  ? 148 LEU A O   1 
ATOM   987  C CB  . LEU A 1 125 ? 117.888 145.609 164.678 1.00 62.78  ? 148 LEU A CB  1 
ATOM   988  C CG  . LEU A 1 125 ? 118.445 144.569 163.708 1.00 62.78  ? 148 LEU A CG  1 
ATOM   989  C CD1 . LEU A 1 125 ? 119.892 144.876 163.371 1.00 62.78  ? 148 LEU A CD1 1 
ATOM   990  C CD2 . LEU A 1 125 ? 118.311 143.174 164.292 1.00 62.78  ? 148 LEU A CD2 1 
ATOM   991  N N   . GLU A 1 126 ? 116.468 145.978 167.441 1.00 71.64  ? 149 GLU A N   1 
ATOM   992  C CA  . GLU A 1 126 ? 116.194 146.770 168.632 1.00 71.64  ? 149 GLU A CA  1 
ATOM   993  C C   . GLU A 1 126 ? 117.201 147.910 168.731 1.00 71.64  ? 149 GLU A C   1 
ATOM   994  O O   . GLU A 1 126 ? 118.415 147.676 168.731 1.00 71.64  ? 149 GLU A O   1 
ATOM   995  C CB  . GLU A 1 126 ? 116.246 145.892 169.879 1.00 71.64  ? 149 GLU A CB  1 
ATOM   996  C CG  . GLU A 1 126 ? 115.705 144.479 169.682 1.00 71.64  ? 149 GLU A CG  1 
ATOM   997  C CD  . GLU A 1 126 ? 114.188 144.422 169.603 1.00 71.64  ? 149 GLU A CD  1 
ATOM   998  O OE1 . GLU A 1 126 ? 113.642 143.301 169.541 1.00 71.64  ? 149 GLU A OE1 1 
ATOM   999  O OE2 . GLU A 1 126 ? 113.539 145.490 169.617 1.00 71.64  ? 149 GLU A OE2 1 
ATOM   1000 N N   . ILE A 1 127 ? 116.701 149.133 168.817 1.00 83.19  ? 150 ILE A N   1 
ATOM   1001 C CA  . ILE A 1 127 ? 117.526 150.336 168.907 1.00 83.19  ? 150 ILE A CA  1 
ATOM   1002 C C   . ILE A 1 127 ? 117.483 150.831 170.346 1.00 83.19  ? 150 ILE A C   1 
ATOM   1003 O O   . ILE A 1 127 ? 116.389 151.020 170.891 1.00 83.19  ? 150 ILE A O   1 
ATOM   1004 C CB  . ILE A 1 127 ? 117.043 151.437 167.942 1.00 83.19  ? 150 ILE A CB  1 
ATOM   1005 C CG1 . ILE A 1 127 ? 116.871 150.877 166.529 1.00 83.19  ? 150 ILE A CG1 1 
ATOM   1006 C CG2 . ILE A 1 127 ? 118.012 152.609 167.938 1.00 83.19  ? 150 ILE A CG2 1 
ATOM   1007 C CD1 . ILE A 1 127 ? 115.427 150.711 166.110 1.00 83.19  ? 150 ILE A CD1 1 
ATOM   1008 N N   . PRO A 1 128 ? 118.635 151.055 170.997 1.00 89.95  ? 151 PRO A N   1 
ATOM   1009 C CA  . PRO A 1 128 ? 118.674 151.534 172.382 1.00 89.95  ? 151 PRO A CA  1 
ATOM   1010 C C   . PRO A 1 128 ? 118.243 152.991 172.509 1.00 89.95  ? 151 PRO A C   1 
ATOM   1011 O O   . PRO A 1 128 ? 118.863 153.730 173.274 1.00 89.95  ? 151 PRO A O   1 
ATOM   1012 C CB  . PRO A 1 128 ? 120.145 151.366 172.766 1.00 89.95  ? 151 PRO A CB  1 
ATOM   1013 C CG  . PRO A 1 128 ? 120.877 151.487 171.477 1.00 89.95  ? 151 PRO A CG  1 
ATOM   1014 C CD  . PRO A 1 128 ? 119.986 150.856 170.443 1.00 89.95  ? 151 PRO A CD  1 
ATOM   1015 N N   . ARG A 1 139 ? 133.013 155.772 184.330 1.00 94.77  ? 162 ARG A N   1 
ATOM   1016 C CA  . ARG A 1 139 ? 133.919 156.178 183.262 1.00 94.77  ? 162 ARG A CA  1 
ATOM   1017 C C   . ARG A 1 139 ? 135.132 156.903 183.837 1.00 94.77  ? 162 ARG A C   1 
ATOM   1018 O O   . ARG A 1 139 ? 135.060 158.086 184.167 1.00 94.77  ? 162 ARG A O   1 
ATOM   1019 C CB  . ARG A 1 139 ? 133.193 157.072 182.252 1.00 94.77  ? 162 ARG A CB  1 
ATOM   1020 C CG  . ARG A 1 139 ? 133.740 156.998 180.830 1.00 94.77  ? 162 ARG A CG  1 
ATOM   1021 C CD  . ARG A 1 139 ? 134.963 157.885 180.643 1.00 94.77  ? 162 ARG A CD  1 
ATOM   1022 N NE  . ARG A 1 139 ? 134.625 159.303 180.704 1.00 94.77  ? 162 ARG A NE  1 
ATOM   1023 C CZ  . ARG A 1 139 ? 135.506 160.287 180.556 1.00 94.77  ? 162 ARG A CZ  1 
ATOM   1024 N NH1 . ARG A 1 139 ? 136.784 160.008 180.340 1.00 94.77  ? 162 ARG A NH1 1 
ATOM   1025 N NH2 . ARG A 1 139 ? 135.110 161.551 180.626 1.00 94.77  ? 162 ARG A NH2 1 
ATOM   1026 N N   . SER A 1 140 ? 136.247 156.184 183.953 1.00 86.61  ? 163 SER A N   1 
ATOM   1027 C CA  . SER A 1 140 ? 137.484 156.747 184.476 1.00 86.61  ? 163 SER A CA  1 
ATOM   1028 C C   . SER A 1 140 ? 138.639 156.317 183.588 1.00 86.61  ? 163 SER A C   1 
ATOM   1029 O O   . SER A 1 140 ? 138.827 155.122 183.344 1.00 86.61  ? 163 SER A O   1 
ATOM   1030 C CB  . SER A 1 140 ? 137.730 156.302 185.922 1.00 86.61  ? 163 SER A CB  1 
ATOM   1031 O OG  . SER A 1 140 ? 136.548 156.408 186.697 1.00 86.61  ? 163 SER A OG  1 
ATOM   1032 N N   . THR A 1 141 ? 139.410 157.295 183.106 1.00 77.87  ? 164 THR A N   1 
ATOM   1033 C CA  . THR A 1 141 ? 140.539 156.981 182.236 1.00 77.87  ? 164 THR A CA  1 
ATOM   1034 C C   . THR A 1 141 ? 141.700 156.390 183.027 1.00 77.87  ? 164 THR A C   1 
ATOM   1035 O O   . THR A 1 141 ? 142.318 155.410 182.594 1.00 77.87  ? 164 THR A O   1 
ATOM   1036 C CB  . THR A 1 141 ? 140.986 158.234 181.483 1.00 77.87  ? 164 THR A CB  1 
ATOM   1037 O OG1 . THR A 1 141 ? 139.908 158.714 180.670 1.00 77.87  ? 164 THR A OG1 1 
ATOM   1038 C CG2 . THR A 1 141 ? 142.178 157.924 180.594 1.00 77.87  ? 164 THR A CG2 1 
ATOM   1039 N N   . THR A 1 142 ? 142.007 156.965 184.186 1.00 75.66  ? 165 THR A N   1 
ATOM   1040 C CA  . THR A 1 142 ? 143.098 156.460 185.007 1.00 75.66  ? 165 THR A CA  1 
ATOM   1041 C C   . THR A 1 142 ? 142.745 155.099 185.596 1.00 75.66  ? 165 THR A C   1 
ATOM   1042 O O   . THR A 1 142 ? 141.572 154.741 185.742 1.00 75.66  ? 165 THR A O   1 
ATOM   1043 C CB  . THR A 1 142 ? 143.428 157.447 186.129 1.00 75.66  ? 165 THR A CB  1 
ATOM   1044 O OG1 . THR A 1 142 ? 144.602 157.009 186.824 1.00 75.66  ? 165 THR A OG1 1 
ATOM   1045 C CG2 . THR A 1 142 ? 142.270 157.551 187.111 1.00 75.66  ? 165 THR A CG2 1 
ATOM   1046 N N   . THR A 1 143 ? 143.780 154.331 185.928 1.00 66.04  ? 166 THR A N   1 
ATOM   1047 C CA  . THR A 1 143 ? 143.621 153.001 186.485 1.00 66.04  ? 166 THR A CA  1 
ATOM   1048 C C   . THR A 1 143 ? 144.385 152.894 187.798 1.00 66.04  ? 166 THR A C   1 
ATOM   1049 O O   . THR A 1 143 ? 145.593 153.168 187.829 1.00 66.04  ? 166 THR A O   1 
ATOM   1050 C CB  . THR A 1 143 ? 144.123 151.930 185.504 1.00 66.04  ? 166 THR A CB  1 
ATOM   1051 O OG1 . THR A 1 143 ? 145.362 152.354 184.923 1.00 66.04  ? 166 THR A OG1 1 
ATOM   1052 C CG2 . THR A 1 143 ? 143.104 151.699 184.402 1.00 66.04  ? 166 THR A CG2 1 
ATOM   1053 N N   . PRO A 1 144 ? 143.728 152.512 188.896 1.00 64.29  ? 167 PRO A N   1 
ATOM   1054 C CA  . PRO A 1 144 ? 144.471 152.343 190.158 1.00 64.29  ? 167 PRO A CA  1 
ATOM   1055 C C   . PRO A 1 144 ? 145.506 151.233 190.091 1.00 64.29  ? 167 PRO A C   1 
ATOM   1056 O O   . PRO A 1 144 ? 146.670 151.447 190.455 1.00 64.29  ? 167 PRO A O   1 
ATOM   1057 C CB  . PRO A 1 144 ? 143.361 152.042 191.176 1.00 64.29  ? 167 PRO A CB  1 
ATOM   1058 C CG  . PRO A 1 144 ? 142.098 152.535 190.538 1.00 64.29  ? 167 PRO A CG  1 
ATOM   1059 C CD  . PRO A 1 144 ? 142.282 152.312 189.072 1.00 64.29  ? 167 PRO A CD  1 
ATOM   1060 N N   . ASP A 1 145 ? 145.113 150.047 189.635 1.00 55.36  ? 168 ASP A N   1 
ATOM   1061 C CA  . ASP A 1 145 ? 146.016 148.916 189.501 1.00 55.36  ? 168 ASP A CA  1 
ATOM   1062 C C   . ASP A 1 145 ? 146.116 148.505 188.038 1.00 55.36  ? 168 ASP A C   1 
ATOM   1063 O O   . ASP A 1 145 ? 145.217 148.764 187.234 1.00 55.36  ? 168 ASP A O   1 
ATOM   1064 C CB  . ASP A 1 145 ? 145.548 147.729 190.352 1.00 55.36  ? 168 ASP A CB  1 
ATOM   1065 C CG  . ASP A 1 145 ? 146.702 146.925 190.913 1.00 55.36  ? 168 ASP A CG  1 
ATOM   1066 O OD1 . ASP A 1 145 ? 147.810 146.995 190.341 1.00 55.36  ? 168 ASP A OD1 1 
ATOM   1067 O OD2 . ASP A 1 145 ? 146.503 146.223 191.927 1.00 55.36  ? 168 ASP A OD2 1 
ATOM   1068 N N   . VAL A 1 146 ? 147.229 147.855 187.700 1.00 46.61  ? 169 VAL A N   1 
ATOM   1069 C CA  . VAL A 1 146 ? 147.475 147.412 186.339 1.00 46.61  ? 169 VAL A CA  1 
ATOM   1070 C C   . VAL A 1 146 ? 147.362 145.897 186.187 1.00 46.61  ? 169 VAL A C   1 
ATOM   1071 O O   . VAL A 1 146 ? 146.929 145.425 185.129 1.00 46.61  ? 169 VAL A O   1 
ATOM   1072 C CB  . VAL A 1 146 ? 148.851 147.908 185.848 1.00 46.61  ? 169 VAL A CB  1 
ATOM   1073 C CG1 . VAL A 1 146 ? 149.007 147.664 184.357 1.00 46.61  ? 169 VAL A CG1 1 
ATOM   1074 C CG2 . VAL A 1 146 ? 149.025 149.382 186.169 1.00 46.61  ? 169 VAL A CG2 1 
ATOM   1075 N N   . PHE A 1 147 ? 147.732 145.124 187.210 1.00 44.46  ? 170 PHE A N   1 
ATOM   1076 C CA  . PHE A 1 147 ? 147.638 143.670 187.122 1.00 44.46  ? 170 PHE A CA  1 
ATOM   1077 C C   . PHE A 1 147 ? 146.192 143.224 186.938 1.00 44.46  ? 170 PHE A C   1 
ATOM   1078 O O   . PHE A 1 147 ? 145.890 142.376 186.087 1.00 44.46  ? 170 PHE A O   1 
ATOM   1079 C CB  . PHE A 1 147 ? 148.246 143.042 188.377 1.00 44.46  ? 170 PHE A CB  1 
ATOM   1080 C CG  . PHE A 1 147 ? 148.769 141.651 188.171 1.00 44.46  ? 170 PHE A CG  1 
ATOM   1081 C CD1 . PHE A 1 147 ? 148.118 140.563 188.726 1.00 44.46  ? 170 PHE A CD1 1 
ATOM   1082 C CD2 . PHE A 1 147 ? 149.915 141.431 187.428 1.00 44.46  ? 170 PHE A CD2 1 
ATOM   1083 C CE1 . PHE A 1 147 ? 148.599 139.282 188.542 1.00 44.46  ? 170 PHE A CE1 1 
ATOM   1084 C CE2 . PHE A 1 147 ? 150.400 140.152 187.239 1.00 44.46  ? 170 PHE A CE2 1 
ATOM   1085 C CZ  . PHE A 1 147 ? 149.740 139.077 187.797 1.00 44.46  ? 170 PHE A CZ  1 
ATOM   1086 N N   . ASN A 1 148 ? 145.280 143.791 187.732 1.00 43.25  ? 171 ASN A N   1 
ATOM   1087 C CA  . ASN A 1 148 ? 143.870 143.438 187.609 1.00 43.25  ? 171 ASN A CA  1 
ATOM   1088 C C   . ASN A 1 148 ? 143.319 143.838 186.248 1.00 43.25  ? 171 ASN A C   1 
ATOM   1089 O O   . ASN A 1 148 ? 142.507 143.114 185.662 1.00 43.25  ? 171 ASN A O   1 
ATOM   1090 C CB  . ASN A 1 148 ? 143.066 144.096 188.729 1.00 43.25  ? 171 ASN A CB  1 
ATOM   1091 C CG  . ASN A 1 148 ? 143.545 143.688 190.107 1.00 43.25  ? 171 ASN A CG  1 
ATOM   1092 O OD1 . ASN A 1 148 ? 144.110 142.609 190.286 1.00 43.25  ? 171 ASN A OD1 1 
ATOM   1093 N ND2 . ASN A 1 148 ? 143.320 144.550 191.091 1.00 43.25  ? 171 ASN A ND2 1 
ATOM   1094 N N   . THR A 1 149 ? 143.756 144.986 185.723 1.00 41.71  ? 172 THR A N   1 
ATOM   1095 C CA  . THR A 1 149 ? 143.305 145.413 184.403 1.00 41.71  ? 172 THR A CA  1 
ATOM   1096 C C   . THR A 1 149 ? 143.790 144.456 183.321 1.00 41.71  ? 172 THR A C   1 
ATOM   1097 O O   . THR A 1 149 ? 143.033 144.104 182.407 1.00 41.71  ? 172 THR A O   1 
ATOM   1098 C CB  . THR A 1 149 ? 143.787 146.835 184.119 1.00 41.71  ? 172 THR A CB  1 
ATOM   1099 O OG1 . THR A 1 149 ? 143.304 147.716 185.140 1.00 41.71  ? 172 THR A OG1 1 
ATOM   1100 C CG2 . THR A 1 149 ? 143.279 147.311 182.768 1.00 41.71  ? 172 THR A CG2 1 
ATOM   1101 N N   . LYS A 1 150 ? 145.050 144.023 183.409 1.00 40.57  ? 173 LYS A N   1 
ATOM   1102 C CA  . LYS A 1 150 ? 145.572 143.053 182.452 1.00 40.57  ? 173 LYS A CA  1 
ATOM   1103 C C   . LYS A 1 150 ? 144.783 141.752 182.508 1.00 40.57  ? 173 LYS A C   1 
ATOM   1104 O O   . LYS A 1 150 ? 144.413 141.190 181.470 1.00 40.57  ? 173 LYS A O   1 
ATOM   1105 C CB  . LYS A 1 150 ? 147.053 142.790 182.724 1.00 40.57  ? 173 LYS A CB  1 
ATOM   1106 C CG  . LYS A 1 150 ? 147.973 143.956 182.417 1.00 40.57  ? 173 LYS A CG  1 
ATOM   1107 C CD  . LYS A 1 150 ? 149.421 143.580 182.682 1.00 40.57  ? 173 LYS A CD  1 
ATOM   1108 C CE  . LYS A 1 150 ? 150.367 144.716 182.341 1.00 40.57  ? 173 LYS A CE  1 
ATOM   1109 N NZ  . LYS A 1 150 ? 151.787 144.333 182.565 1.00 40.57  ? 173 LYS A NZ  1 
ATOM   1110 N N   . ILE A 1 151 ? 144.514 141.259 183.720 1.00 42.77  ? 174 ILE A N   1 
ATOM   1111 C CA  . ILE A 1 151 ? 143.775 140.005 183.863 1.00 42.77  ? 174 ILE A CA  1 
ATOM   1112 C C   . ILE A 1 151 ? 142.365 140.145 183.299 1.00 42.77  ? 174 ILE A C   1 
ATOM   1113 O O   . ILE A 1 151 ? 141.863 139.249 182.606 1.00 42.77  ? 174 ILE A O   1 
ATOM   1114 C CB  . ILE A 1 151 ? 143.756 139.561 185.337 1.00 42.77  ? 174 ILE A CB  1 
ATOM   1115 C CG1 . ILE A 1 151 ? 145.178 139.287 185.829 1.00 42.77  ? 174 ILE A CG1 1 
ATOM   1116 C CG2 . ILE A 1 151 ? 142.885 138.330 185.515 1.00 42.77  ? 174 ILE A CG2 1 
ATOM   1117 C CD1 . ILE A 1 151 ? 145.931 138.284 184.988 1.00 42.77  ? 174 ILE A CD1 1 
ATOM   1118 N N   . GLY A 1 152 ? 141.705 141.271 183.583 1.00 40.24  ? 175 GLY A N   1 
ATOM   1119 C CA  . GLY A 1 152 ? 140.364 141.482 183.067 1.00 40.24  ? 175 GLY A CA  1 
ATOM   1120 C C   . GLY A 1 152 ? 140.324 141.554 181.553 1.00 40.24  ? 175 GLY A C   1 
ATOM   1121 O O   . GLY A 1 152 ? 139.441 140.973 180.919 1.00 40.24  ? 175 GLY A O   1 
ATOM   1122 N N   . SER A 1 153 ? 141.282 142.265 180.953 1.00 38.95  ? 176 SER A N   1 
ATOM   1123 C CA  . SER A 1 153 ? 141.329 142.347 179.497 1.00 38.95  ? 176 SER A CA  1 
ATOM   1124 C C   . SER A 1 153 ? 141.606 140.983 178.878 1.00 38.95  ? 176 SER A C   1 
ATOM   1125 O O   . SER A 1 153 ? 141.024 140.631 177.844 1.00 38.95  ? 176 SER A O   1 
ATOM   1126 C CB  . SER A 1 153 ? 142.386 143.361 179.063 1.00 38.95  ? 176 SER A CB  1 
ATOM   1127 O OG  . SER A 1 153 ? 142.212 144.595 179.736 1.00 38.95  ? 176 SER A OG  1 
ATOM   1128 N N   . CYS A 1 154 ? 142.488 140.199 179.502 1.00 42.29  ? 177 CYS A N   1 
ATOM   1129 C CA  . CYS A 1 154 ? 142.769 138.852 179.015 1.00 42.29  ? 177 CYS A CA  1 
ATOM   1130 C C   . CYS A 1 154 ? 141.513 137.987 179.036 1.00 42.29  ? 177 CYS A C   1 
ATOM   1131 O O   . CYS A 1 154 ? 141.187 137.311 178.049 1.00 42.29  ? 177 CYS A O   1 
ATOM   1132 C CB  . CYS A 1 154 ? 143.873 138.228 179.867 1.00 42.29  ? 177 CYS A CB  1 
ATOM   1133 S SG  . CYS A 1 154 ? 144.728 136.821 179.144 1.00 42.29  ? 177 CYS A SG  1 
ATOM   1134 N N   . GLY A 1 155 ? 140.792 138.001 180.160 1.00 41.68  ? 178 GLY A N   1 
ATOM   1135 C CA  . GLY A 1 155 ? 139.565 137.226 180.247 1.00 41.68  ? 178 GLY A CA  1 
ATOM   1136 C C   . GLY A 1 155 ? 138.513 137.684 179.256 1.00 41.68  ? 178 GLY A C   1 
ATOM   1137 O O   . GLY A 1 155 ? 137.803 136.865 178.661 1.00 41.68  ? 178 GLY A O   1 
ATOM   1138 N N   . PHE A 1 156 ? 138.403 139.000 179.055 1.00 37.46  ? 179 PHE A N   1 
ATOM   1139 C CA  . PHE A 1 156 ? 137.436 139.520 178.096 1.00 37.46  ? 179 PHE A CA  1 
ATOM   1140 C C   . PHE A 1 156 ? 137.770 139.076 176.679 1.00 37.46  ? 179 PHE A C   1 
ATOM   1141 O O   . PHE A 1 156 ? 136.876 138.696 175.916 1.00 37.46  ? 179 PHE A O   1 
ATOM   1142 C CB  . PHE A 1 156 ? 137.377 141.044 178.179 1.00 37.46  ? 179 PHE A CB  1 
ATOM   1143 C CG  . PHE A 1 156 ? 136.653 141.681 177.031 1.00 37.46  ? 179 PHE A CG  1 
ATOM   1144 C CD1 . PHE A 1 156 ? 137.349 142.354 176.043 1.00 37.46  ? 179 PHE A CD1 1 
ATOM   1145 C CD2 . PHE A 1 156 ? 135.275 141.597 176.934 1.00 37.46  ? 179 PHE A CD2 1 
ATOM   1146 C CE1 . PHE A 1 156 ? 136.685 142.936 174.983 1.00 37.46  ? 179 PHE A CE1 1 
ATOM   1147 C CE2 . PHE A 1 156 ? 134.605 142.177 175.877 1.00 37.46  ? 179 PHE A CE2 1 
ATOM   1148 C CZ  . PHE A 1 156 ? 135.311 142.846 174.899 1.00 37.46  ? 179 PHE A CZ  1 
ATOM   1149 N N   . LEU A 1 157 ? 139.052 139.116 176.306 1.00 36.65  ? 180 LEU A N   1 
ATOM   1150 C CA  . LEU A 1 157 ? 139.439 138.674 174.969 1.00 36.65  ? 180 LEU A CA  1 
ATOM   1151 C C   . LEU A 1 157 ? 139.183 137.183 174.784 1.00 36.65  ? 180 LEU A C   1 
ATOM   1152 O O   . LEU A 1 157 ? 138.730 136.752 173.714 1.00 36.65  ? 180 LEU A O   1 
ATOM   1153 C CB  . LEU A 1 157 ? 140.907 139.008 174.709 1.00 36.65  ? 180 LEU A CB  1 
ATOM   1154 C CG  . LEU A 1 157 ? 141.239 140.497 174.607 1.00 36.65  ? 180 LEU A CG  1 
ATOM   1155 C CD1 . LEU A 1 157 ? 142.718 140.703 174.332 1.00 36.65  ? 180 LEU A CD1 1 
ATOM   1156 C CD2 . LEU A 1 157 ? 140.395 141.159 173.534 1.00 36.65  ? 180 LEU A CD2 1 
ATOM   1157 N N   . TRP A 1 158 ? 139.460 136.381 175.815 1.00 40.80  ? 181 TRP A N   1 
ATOM   1158 C CA  . TRP A 1 158 ? 139.179 134.950 175.732 1.00 40.80  ? 181 TRP A CA  1 
ATOM   1159 C C   . TRP A 1 158 ? 137.690 134.696 175.521 1.00 40.80  ? 181 TRP A C   1 
ATOM   1160 O O   . TRP A 1 158 ? 137.293 133.915 174.642 1.00 40.80  ? 181 TRP A O   1 
ATOM   1161 C CB  . TRP A 1 158 ? 139.676 134.252 176.998 1.00 40.80  ? 181 TRP A CB  1 
ATOM   1162 C CG  . TRP A 1 158 ? 139.762 132.764 176.883 1.00 40.80  ? 181 TRP A CG  1 
ATOM   1163 C CD1 . TRP A 1 158 ? 140.627 132.051 176.106 1.00 40.80  ? 181 TRP A CD1 1 
ATOM   1164 C CD2 . TRP A 1 158 ? 138.960 131.802 177.578 1.00 40.80  ? 181 TRP A CD2 1 
ATOM   1165 N NE1 . TRP A 1 158 ? 140.410 130.704 176.269 1.00 40.80  ? 181 TRP A NE1 1 
ATOM   1166 C CE2 . TRP A 1 158 ? 139.392 130.526 177.168 1.00 40.80  ? 181 TRP A CE2 1 
ATOM   1167 C CE3 . TRP A 1 158 ? 137.918 131.897 178.504 1.00 40.80  ? 181 TRP A CE3 1 
ATOM   1168 C CZ2 . TRP A 1 158 ? 138.817 129.353 177.653 1.00 40.80  ? 181 TRP A CZ2 1 
ATOM   1169 C CZ3 . TRP A 1 158 ? 137.348 130.732 178.983 1.00 40.80  ? 181 TRP A CZ3 1 
ATOM   1170 C CH2 . TRP A 1 158 ? 137.799 129.477 178.557 1.00 40.80  ? 181 TRP A CH2 1 
ATOM   1171 N N   . GLY A 1 159 ? 136.847 135.356 176.320 1.00 38.36  ? 182 GLY A N   1 
ATOM   1172 C CA  . GLY A 1 159 ? 135.412 135.193 176.158 1.00 38.36  ? 182 GLY A CA  1 
ATOM   1173 C C   . GLY A 1 159 ? 134.919 135.665 174.805 1.00 38.36  ? 182 GLY A C   1 
ATOM   1174 O O   . GLY A 1 159 ? 134.020 135.062 174.215 1.00 38.36  ? 182 GLY A O   1 
ATOM   1175 N N   . TYR A 1 160 ? 135.509 136.745 174.288 1.00 35.90  ? 183 TYR A N   1 
ATOM   1176 C CA  . TYR A 1 160 ? 135.116 137.258 172.981 1.00 35.90  ? 183 TYR A CA  1 
ATOM   1177 C C   . TYR A 1 160 ? 135.454 136.268 171.874 1.00 35.90  ? 183 TYR A C   1 
ATOM   1178 O O   . TYR A 1 160 ? 134.645 136.043 170.965 1.00 35.90  ? 183 TYR A O   1 
ATOM   1179 C CB  . TYR A 1 160 ? 135.793 138.606 172.735 1.00 35.90  ? 183 TYR A CB  1 
ATOM   1180 C CG  . TYR A 1 160 ? 135.808 139.054 171.294 1.00 35.90  ? 183 TYR A CG  1 
ATOM   1181 C CD1 . TYR A 1 160 ? 134.633 139.393 170.640 1.00 35.90  ? 183 TYR A CD1 1 
ATOM   1182 C CD2 . TYR A 1 160 ? 137.001 139.160 170.594 1.00 35.90  ? 183 TYR A CD2 1 
ATOM   1183 C CE1 . TYR A 1 160 ? 134.644 139.812 169.325 1.00 35.90  ? 183 TYR A CE1 1 
ATOM   1184 C CE2 . TYR A 1 160 ? 137.022 139.578 169.279 1.00 35.90  ? 183 TYR A CE2 1 
ATOM   1185 C CZ  . TYR A 1 160 ? 135.841 139.902 168.650 1.00 35.90  ? 183 TYR A CZ  1 
ATOM   1186 O OH  . TYR A 1 160 ? 135.856 140.320 167.341 1.00 35.90  ? 183 TYR A OH  1 
ATOM   1187 N N   . HIS A 1 161 ? 136.641 135.660 171.937 1.00 35.39  ? 184 HIS A N   1 
ATOM   1188 C CA  . HIS A 1 161 ? 137.001 134.662 170.934 1.00 35.39  ? 184 HIS A CA  1 
ATOM   1189 C C   . HIS A 1 161 ? 136.090 133.443 171.017 1.00 35.39  ? 184 HIS A C   1 
ATOM   1190 O O   . HIS A 1 161 ? 135.672 132.896 169.986 1.00 35.39  ? 184 HIS A O   1 
ATOM   1191 C CB  . HIS A 1 161 ? 138.465 134.256 171.095 1.00 35.39  ? 184 HIS A CB  1 
ATOM   1192 C CG  . HIS A 1 161 ? 139.431 135.271 170.572 1.00 35.39  ? 184 HIS A CG  1 
ATOM   1193 N ND1 . HIS A 1 161 ? 139.422 135.701 169.263 1.00 35.39  ? 184 HIS A ND1 1 
ATOM   1194 C CD2 . HIS A 1 161 ? 140.436 135.943 171.181 1.00 35.39  ? 184 HIS A CD2 1 
ATOM   1195 C CE1 . HIS A 1 161 ? 140.379 136.594 169.088 1.00 35.39  ? 184 HIS A CE1 1 
ATOM   1196 N NE2 . HIS A 1 161 ? 141.010 136.758 170.237 1.00 35.39  ? 184 HIS A NE2 1 
ATOM   1197 N N   . ARG A 1 162 ? 135.762 133.004 172.237 1.00 39.53  ? 185 ARG A N   1 
ATOM   1198 C CA  . ARG A 1 162 ? 134.846 131.874 172.377 1.00 39.53  ? 185 ARG A CA  1 
ATOM   1199 C C   . ARG A 1 162 ? 133.468 132.204 171.810 1.00 39.53  ? 185 ARG A C   1 
ATOM   1200 O O   . ARG A 1 162 ? 132.845 131.369 171.139 1.00 39.53  ? 185 ARG A O   1 
ATOM   1201 C CB  . ARG A 1 162 ? 134.740 131.459 173.844 1.00 39.53  ? 185 ARG A CB  1 
ATOM   1202 C CG  . ARG A 1 162 ? 135.961 130.721 174.368 1.00 39.53  ? 185 ARG A CG  1 
ATOM   1203 C CD  . ARG A 1 162 ? 135.585 129.763 175.485 1.00 39.53  ? 185 ARG A CD  1 
ATOM   1204 N NE  . ARG A 1 162 ? 134.842 130.431 176.549 1.00 39.53  ? 185 ARG A NE  1 
ATOM   1205 C CZ  . ARG A 1 162 ? 134.287 129.804 177.580 1.00 39.53  ? 185 ARG A CZ  1 
ATOM   1206 N NH1 . ARG A 1 162 ? 134.390 128.486 177.690 1.00 39.53  ? 185 ARG A NH1 1 
ATOM   1207 N NH2 . ARG A 1 162 ? 133.629 130.492 178.503 1.00 39.53  ? 185 ARG A NH2 1 
ATOM   1208 N N   . PHE A 1 163 ? 132.979 133.421 172.061 1.00 37.67  ? 186 PHE A N   1 
ATOM   1209 C CA  . PHE A 1 163 ? 131.679 133.820 171.531 1.00 37.67  ? 186 PHE A CA  1 
ATOM   1210 C C   . PHE A 1 163 ? 131.698 133.888 170.010 1.00 37.67  ? 186 PHE A C   1 
ATOM   1211 O O   . PHE A 1 163 ? 130.717 133.520 169.352 1.00 37.67  ? 186 PHE A O   1 
ATOM   1212 C CB  . PHE A 1 163 ? 131.260 135.165 172.123 1.00 37.67  ? 186 PHE A CB  1 
ATOM   1213 C CG  . PHE A 1 163 ? 130.051 135.765 171.467 1.00 37.67  ? 186 PHE A CG  1 
ATOM   1214 C CD1 . PHE A 1 163 ? 130.178 136.833 170.597 1.00 37.67  ? 186 PHE A CD1 1 
ATOM   1215 C CD2 . PHE A 1 163 ? 128.788 135.258 171.717 1.00 37.67  ? 186 PHE A CD2 1 
ATOM   1216 C CE1 . PHE A 1 163 ? 129.068 137.386 169.991 1.00 37.67  ? 186 PHE A CE1 1 
ATOM   1217 C CE2 . PHE A 1 163 ? 127.675 135.806 171.114 1.00 37.67  ? 186 PHE A CE2 1 
ATOM   1218 C CZ  . PHE A 1 163 ? 127.815 136.871 170.250 1.00 37.67  ? 186 PHE A CZ  1 
ATOM   1219 N N   . MET A 1 164 ? 132.803 134.364 169.431 1.00 38.54  ? 187 MET A N   1 
ATOM   1220 C CA  . MET A 1 164 ? 132.903 134.402 167.975 1.00 38.54  ? 187 MET A CA  1 
ATOM   1221 C C   . MET A 1 164 ? 132.903 132.997 167.389 1.00 38.54  ? 187 MET A C   1 
ATOM   1222 O O   . MET A 1 164 ? 132.256 132.742 166.366 1.00 38.54  ? 187 MET A O   1 
ATOM   1223 C CB  . MET A 1 164 ? 134.155 135.166 167.549 1.00 38.54  ? 187 MET A CB  1 
ATOM   1224 C CG  . MET A 1 164 ? 134.058 136.667 167.757 1.00 38.54  ? 187 MET A CG  1 
ATOM   1225 S SD  . MET A 1 164 ? 132.554 137.376 167.061 1.00 38.54  ? 187 MET A SD  1 
ATOM   1226 C CE  . MET A 1 164 ? 132.726 136.929 165.337 1.00 38.54  ? 187 MET A CE  1 
ATOM   1227 N N   . GLY A 1 165 ? 133.618 132.067 168.025 1.00 42.24  ? 188 GLY A N   1 
ATOM   1228 C CA  . GLY A 1 165 ? 133.563 130.685 167.575 1.00 42.24  ? 188 GLY A CA  1 
ATOM   1229 C C   . GLY A 1 165 ? 132.161 130.107 167.646 1.00 42.24  ? 188 GLY A C   1 
ATOM   1230 O O   . GLY A 1 165 ? 131.710 129.418 166.723 1.00 42.24  ? 188 GLY A O   1 
ATOM   1231 N N   . SER A 1 166 ? 131.447 130.393 168.738 1.00 43.67  ? 189 SER A N   1 
ATOM   1232 C CA  . SER A 1 166 ? 130.084 129.888 168.883 1.00 43.67  ? 189 SER A CA  1 
ATOM   1233 C C   . SER A 1 166 ? 129.160 130.459 167.814 1.00 43.67  ? 189 SER A C   1 
ATOM   1234 O O   . SER A 1 166 ? 128.349 129.729 167.228 1.00 43.67  ? 189 SER A O   1 
ATOM   1235 C CB  . SER A 1 166 ? 129.553 130.209 170.279 1.00 43.67  ? 189 SER A CB  1 
ATOM   1236 O OG  . SER A 1 166 ? 128.208 129.786 170.419 1.00 43.67  ? 189 SER A OG  1 
ATOM   1237 N N   . VAL A 1 167 ? 129.262 131.763 167.542 1.00 43.04  ? 190 VAL A N   1 
ATOM   1238 C CA  . VAL A 1 167 ? 128.383 132.368 166.545 1.00 43.04  ? 190 VAL A CA  1 
ATOM   1239 C C   . VAL A 1 167 ? 128.734 131.865 165.149 1.00 43.04  ? 190 VAL A C   1 
ATOM   1240 O O   . VAL A 1 167 ? 127.856 131.717 164.291 1.00 43.04  ? 190 VAL A O   1 
ATOM   1241 C CB  . VAL A 1 167 ? 128.423 133.906 166.637 1.00 43.04  ? 190 VAL A CB  1 
ATOM   1242 C CG1 . VAL A 1 167 ? 129.711 134.468 166.061 1.00 43.04  ? 190 VAL A CG1 1 
ATOM   1243 C CG2 . VAL A 1 167 ? 127.219 134.508 165.935 1.00 43.04  ? 190 VAL A CG2 1 
ATOM   1244 N N   . GLY A 1 168 ? 130.012 131.561 164.905 1.00 46.60  ? 191 GLY A N   1 
ATOM   1245 C CA  . GLY A 1 168 ? 130.378 130.951 163.637 1.00 46.60  ? 191 GLY A CA  1 
ATOM   1246 C C   . GLY A 1 168 ? 129.789 129.564 163.472 1.00 46.60  ? 191 GLY A C   1 
ATOM   1247 O O   . GLY A 1 168 ? 129.309 129.204 162.394 1.00 46.60  ? 191 GLY A O   1 
ATOM   1248 N N   . ARG A 1 169 ? 129.807 128.770 164.545 1.00 50.84  ? 192 ARG A N   1 
ATOM   1249 C CA  . ARG A 1 169 ? 129.193 127.447 164.481 1.00 50.84  ? 192 ARG A CA  1 
ATOM   1250 C C   . ARG A 1 169 ? 127.688 127.550 164.260 1.00 50.84  ? 192 ARG A C   1 
ATOM   1251 O O   . ARG A 1 169 ? 127.101 126.746 163.523 1.00 50.84  ? 192 ARG A O   1 
ATOM   1252 C CB  . ARG A 1 169 ? 129.498 126.664 165.758 1.00 50.84  ? 192 ARG A CB  1 
ATOM   1253 C CG  . ARG A 1 169 ? 129.317 125.163 165.622 1.00 50.84  ? 192 ARG A CG  1 
ATOM   1254 C CD  . ARG A 1 169 ? 130.108 124.410 166.680 1.00 50.84  ? 192 ARG A CD  1 
ATOM   1255 N NE  . ARG A 1 169 ? 131.540 124.684 166.596 1.00 50.84  ? 192 ARG A NE  1 
ATOM   1256 C CZ  . ARG A 1 169 ? 132.202 125.472 167.438 1.00 50.84  ? 192 ARG A CZ  1 
ATOM   1257 N NH1 . ARG A 1 169 ? 133.504 125.665 167.285 1.00 50.84  ? 192 ARG A NH1 1 
ATOM   1258 N NH2 . ARG A 1 169 ? 131.561 126.066 168.435 1.00 50.84  ? 192 ARG A NH2 1 
ATOM   1259 N N   . VAL A 1 170 ? 127.047 128.542 164.881 1.00 49.76  ? 193 VAL A N   1 
ATOM   1260 C CA  . VAL A 1 170 ? 125.611 128.725 164.686 1.00 49.76  ? 193 VAL A CA  1 
ATOM   1261 C C   . VAL A 1 170 ? 125.312 129.141 163.249 1.00 49.76  ? 193 VAL A C   1 
ATOM   1262 O O   . VAL A 1 170 ? 124.333 128.684 162.648 1.00 49.76  ? 193 VAL A O   1 
ATOM   1263 C CB  . VAL A 1 170 ? 125.056 129.740 165.702 1.00 49.76  ? 193 VAL A CB  1 
ATOM   1264 C CG1 . VAL A 1 170 ? 123.608 130.074 165.384 1.00 49.76  ? 193 VAL A CG1 1 
ATOM   1265 C CG2 . VAL A 1 170 ? 125.171 129.189 167.113 1.00 49.76  ? 193 VAL A CG2 1 
ATOM   1266 N N   . PHE A 1 171 ? 126.150 130.008 162.673 1.00 50.47  ? 194 PHE A N   1 
ATOM   1267 C CA  . PHE A 1 171 ? 125.975 130.381 161.271 1.00 50.47  ? 194 PHE A CA  1 
ATOM   1268 C C   . PHE A 1 171 ? 126.162 129.181 160.352 1.00 50.47  ? 194 PHE A C   1 
ATOM   1269 O O   . PHE A 1 171 ? 125.449 129.037 159.351 1.00 50.47  ? 194 PHE A O   1 
ATOM   1270 C CB  . PHE A 1 171 ? 126.948 131.498 160.896 1.00 50.47  ? 194 PHE A CB  1 
ATOM   1271 C CG  . PHE A 1 171 ? 126.451 132.873 161.230 1.00 50.47  ? 194 PHE A CG  1 
ATOM   1272 C CD1 . PHE A 1 171 ? 125.094 133.132 161.316 1.00 50.47  ? 194 PHE A CD1 1 
ATOM   1273 C CD2 . PHE A 1 171 ? 127.342 133.907 161.459 1.00 50.47  ? 194 PHE A CD2 1 
ATOM   1274 C CE1 . PHE A 1 171 ? 124.635 134.396 161.623 1.00 50.47  ? 194 PHE A CE1 1 
ATOM   1275 C CE2 . PHE A 1 171 ? 126.889 135.174 161.767 1.00 50.47  ? 194 PHE A CE2 1 
ATOM   1276 C CZ  . PHE A 1 171 ? 125.533 135.419 161.849 1.00 50.47  ? 194 PHE A CZ  1 
ATOM   1277 N N   . ARG A 1 172 ? 127.123 128.310 160.670 1.00 56.75  ? 195 ARG A N   1 
ATOM   1278 C CA  . ARG A 1 172 ? 127.315 127.107 159.865 1.00 56.75  ? 195 ARG A CA  1 
ATOM   1279 C C   . ARG A 1 172 ? 126.102 126.190 159.949 1.00 56.75  ? 195 ARG A C   1 
ATOM   1280 O O   . ARG A 1 172 ? 125.671 125.623 158.938 1.00 56.75  ? 195 ARG A O   1 
ATOM   1281 C CB  . ARG A 1 172 ? 128.577 126.368 160.310 1.00 56.75  ? 195 ARG A CB  1 
ATOM   1282 C CG  . ARG A 1 172 ? 129.084 125.356 159.296 1.00 56.75  ? 195 ARG A CG  1 
ATOM   1283 C CD  . ARG A 1 172 ? 130.362 124.685 159.773 1.00 56.75  ? 195 ARG A CD  1 
ATOM   1284 N NE  . ARG A 1 172 ? 131.269 125.628 160.420 1.00 56.75  ? 195 ARG A NE  1 
ATOM   1285 C CZ  . ARG A 1 172 ? 132.094 126.440 159.767 1.00 56.75  ? 195 ARG A CZ  1 
ATOM   1286 N NH1 . ARG A 1 172 ? 132.884 127.264 160.440 1.00 56.75  ? 195 ARG A NH1 1 
ATOM   1287 N NH2 . ARG A 1 172 ? 132.130 126.428 158.441 1.00 56.75  ? 195 ARG A NH2 1 
ATOM   1288 N N   . GLU A 1 173 ? 125.537 126.031 161.148 1.00 61.34  ? 196 GLU A N   1 
ATOM   1289 C CA  . GLU A 1 173 ? 124.327 125.225 161.288 1.00 61.34  ? 196 GLU A CA  1 
ATOM   1290 C C   . GLU A 1 173 ? 123.161 125.846 160.526 1.00 61.34  ? 196 GLU A C   1 
ATOM   1291 O O   . GLU A 1 173 ? 122.340 125.131 159.940 1.00 61.34  ? 196 GLU A O   1 
ATOM   1292 C CB  . GLU A 1 173 ? 123.975 125.054 162.766 1.00 61.34  ? 196 GLU A CB  1 
ATOM   1293 C CG  . GLU A 1 173 ? 124.951 124.182 163.536 1.00 61.34  ? 196 GLU A CG  1 
ATOM   1294 C CD  . GLU A 1 173 ? 124.833 122.715 163.174 1.00 61.34  ? 196 GLU A CD  1 
ATOM   1295 O OE1 . GLU A 1 173 ? 123.766 122.310 162.666 1.00 61.34  ? 196 GLU A OE1 1 
ATOM   1296 O OE2 . GLU A 1 173 ? 125.807 121.966 163.397 1.00 61.34  ? 196 GLU A OE2 1 
ATOM   1297 N N   . TRP A 1 174 ? 123.075 127.178 160.522 1.00 62.39  ? 197 TRP A N   1 
ATOM   1298 C CA  . TRP A 1 174 ? 122.025 127.854 159.766 1.00 62.39  ? 197 TRP A CA  1 
ATOM   1299 C C   . TRP A 1 174 ? 122.189 127.619 158.270 1.00 62.39  ? 197 TRP A C   1 
ATOM   1300 O O   . TRP A 1 174 ? 121.205 127.401 157.555 1.00 62.39  ? 197 TRP A O   1 
ATOM   1301 C CB  . TRP A 1 174 ? 122.041 129.351 160.082 1.00 62.39  ? 197 TRP A CB  1 
ATOM   1302 C CG  . TRP A 1 174 ? 120.826 130.100 159.617 1.00 62.39  ? 197 TRP A CG  1 
ATOM   1303 C CD1 . TRP A 1 174 ? 119.734 129.586 158.982 1.00 62.39  ? 197 TRP A CD1 1 
ATOM   1304 C CD2 . TRP A 1 174 ? 120.586 131.506 159.753 1.00 62.39  ? 197 TRP A CD2 1 
ATOM   1305 N NE1 . TRP A 1 174 ? 118.829 130.584 158.714 1.00 62.39  ? 197 TRP A NE1 1 
ATOM   1306 C CE2 . TRP A 1 174 ? 119.328 131.772 159.178 1.00 62.39  ? 197 TRP A CE2 1 
ATOM   1307 C CE3 . TRP A 1 174 ? 121.312 132.564 160.306 1.00 62.39  ? 197 TRP A CE3 1 
ATOM   1308 C CZ2 . TRP A 1 174 ? 118.782 133.052 159.140 1.00 62.39  ? 197 TRP A CZ2 1 
ATOM   1309 C CZ3 . TRP A 1 174 ? 120.768 133.833 160.267 1.00 62.39  ? 197 TRP A CZ3 1 
ATOM   1310 C CH2 . TRP A 1 174 ? 119.515 134.067 159.689 1.00 62.39  ? 197 TRP A CH2 1 
ATOM   1311 N N   . ASP A 1 175 ? 123.429 127.666 157.779 1.00 67.82  ? 198 ASP A N   1 
ATOM   1312 C CA  . ASP A 1 175 ? 123.673 127.398 156.365 1.00 67.82  ? 198 ASP A CA  1 
ATOM   1313 C C   . ASP A 1 175 ? 123.366 125.946 156.020 1.00 67.82  ? 198 ASP A C   1 
ATOM   1314 O O   . ASP A 1 175 ? 122.886 125.651 154.919 1.00 67.82  ? 198 ASP A O   1 
ATOM   1315 C CB  . ASP A 1 175 ? 125.118 127.742 156.005 1.00 67.82  ? 198 ASP A CB  1 
ATOM   1316 C CG  . ASP A 1 175 ? 125.468 127.366 154.580 1.00 67.82  ? 198 ASP A CG  1 
ATOM   1317 O OD1 . ASP A 1 175 ? 124.959 128.023 153.648 1.00 67.82  ? 198 ASP A OD1 1 
ATOM   1318 O OD2 . ASP A 1 175 ? 126.250 126.411 154.390 1.00 67.82  ? 198 ASP A OD2 1 
ATOM   1319 N N   . ASP A 1 176 ? 123.638 125.026 156.949 1.00 75.24  ? 199 ASP A N   1 
ATOM   1320 C CA  . ASP A 1 176 ? 123.308 123.623 156.720 1.00 75.24  ? 199 ASP A CA  1 
ATOM   1321 C C   . ASP A 1 176 ? 121.800 123.412 156.672 1.00 75.24  ? 199 ASP A C   1 
ATOM   1322 O O   . ASP A 1 176 ? 121.299 122.656 155.831 1.00 75.24  ? 199 ASP A O   1 
ATOM   1323 C CB  . ASP A 1 176 ? 123.939 122.753 157.809 1.00 75.24  ? 199 ASP A CB  1 
ATOM   1324 C CG  . ASP A 1 176 ? 124.146 121.316 157.365 1.00 75.24  ? 199 ASP A CG  1 
ATOM   1325 O OD1 . ASP A 1 176 ? 123.242 120.751 156.715 1.00 75.24  ? 199 ASP A OD1 1 
ATOM   1326 O OD2 . ASP A 1 176 ? 125.217 120.749 157.670 1.00 75.24  ? 199 ASP A OD2 1 
ATOM   1327 N N   . GLY A 1 177 ? 121.062 124.071 157.562 1.00 78.71  ? 200 GLY A N   1 
ATOM   1328 C CA  . GLY A 1 177 ? 119.617 123.957 157.582 1.00 78.71  ? 200 GLY A CA  1 
ATOM   1329 C C   . GLY A 1 177 ? 118.957 124.605 156.383 1.00 78.71  ? 200 GLY A C   1 
ATOM   1330 O O   . GLY A 1 177 ? 118.375 123.913 155.541 1.00 78.71  ? 200 GLY A O   1 
ATOM   1331 N N   . SER A 1 178 ? 119.047 125.934 156.298 1.00 80.11  ? 201 SER A N   1 
ATOM   1332 C CA  . SER A 1 178 ? 118.493 126.704 155.182 1.00 80.11  ? 201 SER A CA  1 
ATOM   1333 C C   . SER A 1 178 ? 117.004 126.416 154.993 1.00 80.11  ? 201 SER A C   1 
ATOM   1334 O O   . SER A 1 178 ? 116.531 126.153 153.885 1.00 80.11  ? 201 SER A O   1 
ATOM   1335 C CB  . SER A 1 178 ? 119.274 126.438 153.892 1.00 80.11  ? 201 SER A CB  1 
ATOM   1336 O OG  . SER A 1 178 ? 120.671 126.474 154.128 1.00 80.11  ? 201 SER A OG  1 
ATOM   1337 N N   . THR A 1 179 ? 116.261 126.468 156.094 1.00 87.44  ? 202 THR A N   1 
ATOM   1338 C CA  . THR A 1 179 ? 114.824 126.224 156.058 1.00 87.44  ? 202 THR A CA  1 
ATOM   1339 C C   . THR A 1 179 ? 114.079 127.429 155.491 1.00 87.44  ? 202 THR A C   1 
ATOM   1340 O O   . THR A 1 179 ? 113.015 127.286 154.890 1.00 87.44  ? 202 THR A O   1 
ATOM   1341 C CB  . THR A 1 179 ? 114.270 125.902 157.458 1.00 87.44  ? 202 THR A CB  1 
ATOM   1342 O OG1 . THR A 1 179 ? 112.902 125.492 157.351 1.00 87.44  ? 202 THR A OG1 1 
ATOM   1343 C CG2 . THR A 1 179 ? 114.359 127.123 158.360 1.00 87.44  ? 202 THR A CG2 1 
ATOM   1344 N N   . PHE B 2 102 ? 132.343 174.458 127.334 1.00 79.76  ? 124 PHE B N   1 
ATOM   1345 C CA  . PHE B 2 102 ? 131.094 173.730 127.522 1.00 79.76  ? 124 PHE B CA  1 
ATOM   1346 C C   . PHE B 2 102 ? 131.170 172.823 128.752 1.00 79.76  ? 124 PHE B C   1 
ATOM   1347 O O   . PHE B 2 102 ? 132.255 172.386 129.135 1.00 79.76  ? 124 PHE B O   1 
ATOM   1348 C CB  . PHE B 2 102 ? 130.752 172.916 126.267 1.00 79.76  ? 124 PHE B CB  1 
ATOM   1349 C CG  . PHE B 2 102 ? 131.952 172.387 125.533 1.00 79.76  ? 124 PHE B CG  1 
ATOM   1350 C CD1 . PHE B 2 102 ? 132.492 173.086 124.466 1.00 79.76  ? 124 PHE B CD1 1 
ATOM   1351 C CD2 . PHE B 2 102 ? 132.531 171.185 125.901 1.00 79.76  ? 124 PHE B CD2 1 
ATOM   1352 C CE1 . PHE B 2 102 ? 133.592 172.601 123.786 1.00 79.76  ? 124 PHE B CE1 1 
ATOM   1353 C CE2 . PHE B 2 102 ? 133.630 170.694 125.224 1.00 79.76  ? 124 PHE B CE2 1 
ATOM   1354 C CZ  . PHE B 2 102 ? 134.161 171.403 124.165 1.00 79.76  ? 124 PHE B CZ  1 
ATOM   1355 N N   . PRO B 2 103 ? 130.024 172.552 129.372 1.00 77.81  ? 125 PRO B N   1 
ATOM   1356 C CA  . PRO B 2 103 ? 130.007 171.723 130.585 1.00 77.81  ? 125 PRO B CA  1 
ATOM   1357 C C   . PRO B 2 103 ? 130.466 170.307 130.289 1.00 77.81  ? 125 PRO B C   1 
ATOM   1358 O O   . PRO B 2 103 ? 130.414 169.856 129.135 1.00 77.81  ? 125 PRO B O   1 
ATOM   1359 C CB  . PRO B 2 103 ? 128.531 171.755 131.013 1.00 77.81  ? 125 PRO B CB  1 
ATOM   1360 C CG  . PRO B 2 103 ? 127.782 172.101 129.772 1.00 77.81  ? 125 PRO B CG  1 
ATOM   1361 C CD  . PRO B 2 103 ? 128.677 173.038 129.025 1.00 77.81  ? 125 PRO B CD  1 
ATOM   1362 N N   . PRO B 2 104 ? 130.923 169.568 131.309 1.00 75.49  ? 126 PRO B N   1 
ATOM   1363 C CA  . PRO B 2 104 ? 131.421 168.208 131.066 1.00 75.49  ? 126 PRO B CA  1 
ATOM   1364 C C   . PRO B 2 104 ? 130.305 167.215 130.789 1.00 75.49  ? 126 PRO B C   1 
ATOM   1365 O O   . PRO B 2 104 ? 129.124 167.575 130.793 1.00 75.49  ? 126 PRO B O   1 
ATOM   1366 C CB  . PRO B 2 104 ? 132.156 167.872 132.368 1.00 75.49  ? 126 PRO B CB  1 
ATOM   1367 C CG  . PRO B 2 104 ? 131.433 168.661 133.402 1.00 75.49  ? 126 PRO B CG  1 
ATOM   1368 C CD  . PRO B 2 104 ? 131.023 169.945 132.730 1.00 75.49  ? 126 PRO B CD  1 
ATOM   1369 N N   . ASP B 2 105 ? 130.673 165.961 130.553 1.00 72.70  ? 127 ASP B N   1 
ATOM   1370 C CA  . ASP B 2 105 ? 129.728 164.890 130.279 1.00 72.70  ? 127 ASP B CA  1 
ATOM   1371 C C   . ASP B 2 105 ? 129.739 163.886 131.427 1.00 72.70  ? 127 ASP B C   1 
ATOM   1372 O O   . ASP B 2 105 ? 130.533 163.983 132.366 1.00 72.70  ? 127 ASP B O   1 
ATOM   1373 C CB  . ASP B 2 105 ? 130.055 164.214 128.946 1.00 72.70  ? 127 ASP B CB  1 
ATOM   1374 C CG  . ASP B 2 105 ? 128.815 163.772 128.198 1.00 72.70  ? 127 ASP B CG  1 
ATOM   1375 O OD1 . ASP B 2 105 ? 128.900 162.793 127.427 1.00 72.70  ? 127 ASP B OD1 1 
ATOM   1376 O OD2 . ASP B 2 105 ? 127.753 164.404 128.379 1.00 72.70  ? 127 ASP B OD2 1 
ATOM   1377 N N   . LYS B 2 106 ? 128.844 162.910 131.342 1.00 65.51  ? 128 LYS B N   1 
ATOM   1378 C CA  . LYS B 2 106 ? 128.715 161.907 132.392 1.00 65.51  ? 128 LYS B CA  1 
ATOM   1379 C C   . LYS B 2 106 ? 129.857 160.903 132.293 1.00 65.51  ? 128 LYS B C   1 
ATOM   1380 O O   . LYS B 2 106 ? 130.010 160.258 131.249 1.00 65.51  ? 128 LYS B O   1 
ATOM   1381 C CB  . LYS B 2 106 ? 127.375 161.194 132.281 1.00 65.51  ? 128 LYS B CB  1 
ATOM   1382 C CG  . LYS B 2 106 ? 126.816 160.710 133.606 1.00 65.51  ? 128 LYS B CG  1 
ATOM   1383 C CD  . LYS B 2 106 ? 125.337 160.386 133.488 1.00 65.51  ? 128 LYS B CD  1 
ATOM   1384 C CE  . LYS B 2 106 ? 124.719 160.123 134.851 1.00 65.51  ? 128 LYS B CE  1 
ATOM   1385 N NZ  . LYS B 2 106 ? 123.244 159.949 134.767 1.00 65.51  ? 128 LYS B NZ  1 
ATOM   1386 N N   . PRO B 2 107 ? 130.674 160.745 133.331 1.00 59.98  ? 129 PRO B N   1 
ATOM   1387 C CA  . PRO B 2 107 ? 131.781 159.786 133.258 1.00 59.98  ? 129 PRO B CA  1 
ATOM   1388 C C   . PRO B 2 107 ? 131.280 158.354 133.155 1.00 59.98  ? 129 PRO B C   1 
ATOM   1389 O O   . PRO B 2 107 ? 130.191 158.014 133.622 1.00 59.98  ? 129 PRO B O   1 
ATOM   1390 C CB  . PRO B 2 107 ? 132.539 160.013 134.572 1.00 59.98  ? 129 PRO B CB  1 
ATOM   1391 C CG  . PRO B 2 107 ? 132.096 161.360 135.050 1.00 59.98  ? 129 PRO B CG  1 
ATOM   1392 C CD  . PRO B 2 107 ? 130.682 161.504 134.591 1.00 59.98  ? 129 PRO B CD  1 
ATOM   1393 N N   . THR B 2 108 ? 132.096 157.511 132.526 1.00 64.99  ? 130 THR B N   1 
ATOM   1394 C CA  . THR B 2 108 ? 131.784 156.097 132.354 1.00 64.99  ? 130 THR B CA  1 
ATOM   1395 C C   . THR B 2 108 ? 133.043 155.292 132.661 1.00 64.99  ? 130 THR B C   1 
ATOM   1396 O O   . THR B 2 108 ? 134.048 155.833 133.134 1.00 64.99  ? 130 THR B O   1 
ATOM   1397 C CB  . THR B 2 108 ? 131.256 155.814 130.940 1.00 64.99  ? 130 THR B CB  1 
ATOM   1398 O OG1 . THR B 2 108 ? 132.183 156.318 129.971 1.00 64.99  ? 130 THR B OG1 1 
ATOM   1399 C CG2 . THR B 2 108 ? 129.895 156.462 130.726 1.00 64.99  ? 130 THR B CG2 1 
ATOM   1400 N N   . ASN B 2 109 ? 132.979 153.987 132.391 1.00 69.12  ? 131 ASN B N   1 
ATOM   1401 C CA  . ASN B 2 109 ? 134.109 153.076 132.574 1.00 69.12  ? 131 ASN B CA  1 
ATOM   1402 C C   . ASN B 2 109 ? 134.633 153.123 134.008 1.00 69.12  ? 131 ASN B C   1 
ATOM   1403 O O   . ASN B 2 109 ? 135.836 153.228 134.257 1.00 69.12  ? 131 ASN B O   1 
ATOM   1404 C CB  . ASN B 2 109 ? 135.227 153.382 131.576 1.00 69.12  ? 131 ASN B CB  1 
ATOM   1405 C CG  . ASN B 2 109 ? 134.786 153.213 130.134 1.00 69.12  ? 131 ASN B CG  1 
ATOM   1406 O OD1 . ASN B 2 109 ? 133.830 153.851 129.693 1.00 69.12  ? 131 ASN B OD1 1 
ATOM   1407 N ND2 . ASN B 2 109 ? 135.482 152.357 129.388 1.00 69.12  ? 131 ASN B ND2 1 
ATOM   1408 N N   . LEU B 2 110 ? 133.710 153.045 134.962 1.00 57.81  ? 132 LEU B N   1 
ATOM   1409 C CA  . LEU B 2 110 ? 134.059 153.106 136.380 1.00 57.81  ? 132 LEU B CA  1 
ATOM   1410 C C   . LEU B 2 110 ? 134.448 151.710 136.850 1.00 57.81  ? 132 LEU B C   1 
ATOM   1411 O O   . LEU B 2 110 ? 133.592 150.846 137.049 1.00 57.81  ? 132 LEU B O   1 
ATOM   1412 C CB  . LEU B 2 110 ? 132.898 153.663 137.195 1.00 57.81  ? 132 LEU B CB  1 
ATOM   1413 C CG  . LEU B 2 110 ? 133.154 153.827 138.693 1.00 57.81  ? 132 LEU B CG  1 
ATOM   1414 C CD1 . LEU B 2 110 ? 134.361 154.717 138.935 1.00 57.81  ? 132 LEU B CD1 1 
ATOM   1415 C CD2 . LEU B 2 110 ? 131.926 154.387 139.387 1.00 57.81  ? 132 LEU B CD2 1 
ATOM   1416 N N   . THR B 2 111 ? 135.748 151.486 137.026 1.00 58.60  ? 133 THR B N   1 
ATOM   1417 C CA  . THR B 2 111 ? 136.269 150.216 137.508 1.00 58.60  ? 133 THR B CA  1 
ATOM   1418 C C   . THR B 2 111 ? 137.287 150.470 138.609 1.00 58.60  ? 133 THR B C   1 
ATOM   1419 O O   . THR B 2 111 ? 137.929 151.523 138.652 1.00 58.60  ? 133 THR B O   1 
ATOM   1420 C CB  . THR B 2 111 ? 136.921 149.403 136.381 1.00 58.60  ? 133 THR B CB  1 
ATOM   1421 O OG1 . THR B 2 111 ? 137.779 150.253 135.610 1.00 58.60  ? 133 THR B OG1 1 
ATOM   1422 C CG2 . THR B 2 111 ? 135.858 148.803 135.472 1.00 58.60  ? 133 THR B CG2 1 
ATOM   1423 N N   . CYS B 2 112 ? 137.430 149.493 139.502 1.00 53.55  ? 134 CYS B N   1 
ATOM   1424 C CA  . CYS B 2 112 ? 138.347 149.600 140.628 1.00 53.55  ? 134 CYS B CA  1 
ATOM   1425 C C   . CYS B 2 112 ? 139.137 148.309 140.769 1.00 53.55  ? 134 CYS B C   1 
ATOM   1426 O O   . CYS B 2 112 ? 138.601 147.218 140.553 1.00 53.55  ? 134 CYS B O   1 
ATOM   1427 C CB  . CYS B 2 112 ? 137.598 149.902 141.932 1.00 53.55  ? 134 CYS B CB  1 
ATOM   1428 S SG  . CYS B 2 112 ? 136.671 151.454 141.920 1.00 53.55  ? 134 CYS B SG  1 
ATOM   1429 N N   . ILE B 2 113 ? 140.410 148.440 141.134 1.00 51.59  ? 135 ILE B N   1 
ATOM   1430 C CA  . ILE B 2 113 ? 141.307 147.306 141.317 1.00 51.59  ? 135 ILE B CA  1 
ATOM   1431 C C   . ILE B 2 113 ? 142.019 147.462 142.653 1.00 51.59  ? 135 ILE B C   1 
ATOM   1432 O O   . ILE B 2 113 ? 142.418 148.569 143.030 1.00 51.59  ? 135 ILE B O   1 
ATOM   1433 C CB  . ILE B 2 113 ? 142.322 147.193 140.157 1.00 51.59  ? 135 ILE B CB  1 
ATOM   1434 C CG1 . ILE B 2 113 ? 143.317 146.057 140.412 1.00 51.59  ? 135 ILE B CG1 1 
ATOM   1435 C CG2 . ILE B 2 113 ? 143.045 148.515 139.939 1.00 51.59  ? 135 ILE B CG2 1 
ATOM   1436 C CD1 . ILE B 2 113 ? 144.355 145.898 139.324 1.00 51.59  ? 135 ILE B CD1 1 
ATOM   1437 N N   . VAL B 2 114 ? 142.169 146.354 143.374 1.00 51.20  ? 136 VAL B N   1 
ATOM   1438 C CA  . VAL B 2 114 ? 142.807 146.338 144.685 1.00 51.20  ? 136 VAL B CA  1 
ATOM   1439 C C   . VAL B 2 114 ? 144.057 145.478 144.584 1.00 51.20  ? 136 VAL B C   1 
ATOM   1440 O O   . VAL B 2 114 ? 143.966 144.249 144.473 1.00 51.20  ? 136 VAL B O   1 
ATOM   1441 C CB  . VAL B 2 114 ? 141.867 145.810 145.777 1.00 51.20  ? 136 VAL B CB  1 
ATOM   1442 C CG1 . VAL B 2 114 ? 142.598 145.717 147.105 1.00 51.20  ? 136 VAL B CG1 1 
ATOM   1443 C CG2 . VAL B 2 114 ? 140.641 146.698 145.897 1.00 51.20  ? 136 VAL B CG2 1 
ATOM   1444 N N   . ASN B 2 115 ? 145.223 146.114 144.619 1.00 57.35  ? 137 ASN B N   1 
ATOM   1445 C CA  . ASN B 2 115 ? 146.475 145.377 144.634 1.00 57.35  ? 137 ASN B CA  1 
ATOM   1446 C C   . ASN B 2 115 ? 146.727 144.798 146.020 1.00 57.35  ? 137 ASN B C   1 
ATOM   1447 O O   . ASN B 2 115 ? 146.343 145.379 147.038 1.00 57.35  ? 137 ASN B O   1 
ATOM   1448 C CB  . ASN B 2 115 ? 147.639 146.280 144.228 1.00 57.35  ? 137 ASN B CB  1 
ATOM   1449 C CG  . ASN B 2 115 ? 147.460 146.876 142.849 1.00 57.35  ? 137 ASN B CG  1 
ATOM   1450 O OD1 . ASN B 2 115 ? 147.849 146.279 141.846 1.00 57.35  ? 137 ASN B OD1 1 
ATOM   1451 N ND2 . ASN B 2 115 ? 146.869 148.064 142.790 1.00 57.35  ? 137 ASN B ND2 1 
ATOM   1452 N N   . GLU B 2 116 ? 147.379 143.640 146.051 1.00 60.51  ? 138 GLU B N   1 
ATOM   1453 C CA  . GLU B 2 116 ? 147.684 142.989 147.318 1.00 60.51  ? 138 GLU B CA  1 
ATOM   1454 C C   . GLU B 2 116 ? 148.725 143.801 148.076 1.00 60.51  ? 138 GLU B C   1 
ATOM   1455 O O   . GLU B 2 116 ? 149.847 143.992 147.594 1.00 60.51  ? 138 GLU B O   1 
ATOM   1456 C CB  . GLU B 2 116 ? 148.179 141.566 147.080 1.00 60.51  ? 138 GLU B CB  1 
ATOM   1457 C CG  . GLU B 2 116 ? 148.665 140.869 148.340 1.00 60.51  ? 138 GLU B CG  1 
ATOM   1458 C CD  . GLU B 2 116 ? 148.889 139.386 148.137 1.00 60.51  ? 138 GLU B CD  1 
ATOM   1459 O OE1 . GLU B 2 116 ? 148.742 138.623 149.115 1.00 60.51  ? 138 GLU B OE1 1 
ATOM   1460 O OE2 . GLU B 2 116 ? 149.203 138.982 146.998 1.00 60.51  ? 138 GLU B OE2 1 
ATOM   1461 N N   . GLY B 2 117 ? 148.355 144.276 149.261 1.00 61.70  ? 139 GLY B N   1 
ATOM   1462 C CA  . GLY B 2 117 ? 149.235 145.095 150.066 1.00 61.70  ? 139 GLY B CA  1 
ATOM   1463 C C   . GLY B 2 117 ? 149.107 146.584 149.850 1.00 61.70  ? 139 GLY B C   1 
ATOM   1464 O O   . GLY B 2 117 ? 149.930 147.341 150.378 1.00 61.70  ? 139 GLY B O   1 
ATOM   1465 N N   . LYS B 2 118 ? 148.110 147.032 149.091 1.00 62.03  ? 140 LYS B N   1 
ATOM   1466 C CA  . LYS B 2 118 ? 147.902 148.448 148.836 1.00 62.03  ? 140 LYS B CA  1 
ATOM   1467 C C   . LYS B 2 118 ? 146.415 148.756 148.934 1.00 62.03  ? 140 LYS B C   1 
ATOM   1468 O O   . LYS B 2 118 ? 145.584 147.867 149.135 1.00 62.03  ? 140 LYS B O   1 
ATOM   1469 C CB  . LYS B 2 118 ? 148.451 148.861 147.464 1.00 62.03  ? 140 LYS B CB  1 
ATOM   1470 C CG  . LYS B 2 118 ? 149.953 148.685 147.314 1.00 62.03  ? 140 LYS B CG  1 
ATOM   1471 C CD  . LYS B 2 118 ? 150.403 149.004 145.900 1.00 62.03  ? 140 LYS B CD  1 
ATOM   1472 C CE  . LYS B 2 118 ? 151.891 148.749 145.722 1.00 62.03  ? 140 LYS B CE  1 
ATOM   1473 N NZ  . LYS B 2 118 ? 152.345 149.039 144.333 1.00 62.03  ? 140 LYS B NZ  1 
ATOM   1474 N N   . ASN B 2 119 ? 146.086 150.037 148.794 1.00 60.31  ? 141 ASN B N   1 
ATOM   1475 C CA  . ASN B 2 119 ? 144.703 150.477 148.872 1.00 60.31  ? 141 ASN B CA  1 
ATOM   1476 C C   . ASN B 2 119 ? 143.995 150.272 147.534 1.00 60.31  ? 141 ASN B C   1 
ATOM   1477 O O   . ASN B 2 119 ? 144.593 149.872 146.532 1.00 60.31  ? 141 ASN B O   1 
ATOM   1478 C CB  . ASN B 2 119 ? 144.630 151.945 149.289 1.00 60.31  ? 141 ASN B CB  1 
ATOM   1479 C CG  . ASN B 2 119 ? 145.154 152.179 150.689 1.00 60.31  ? 141 ASN B CG  1 
ATOM   1480 O OD1 . ASN B 2 119 ? 145.018 151.329 151.563 1.00 60.31  ? 141 ASN B OD1 1 
ATOM   1481 N ND2 . ASN B 2 119 ? 145.754 153.341 150.908 1.00 60.31  ? 141 ASN B ND2 1 
ATOM   1482 N N   . MET B 2 120 ? 142.696 150.554 147.531 1.00 56.55  ? 142 MET B N   1 
ATOM   1483 C CA  . MET B 2 120 ? 141.884 150.404 146.332 1.00 56.55  ? 142 MET B CA  1 
ATOM   1484 C C   . MET B 2 120 ? 142.149 151.555 145.370 1.00 56.55  ? 142 MET B C   1 
ATOM   1485 O O   . MET B 2 120 ? 142.165 152.722 145.771 1.00 56.55  ? 142 MET B O   1 
ATOM   1486 C CB  . MET B 2 120 ? 140.402 150.347 146.699 1.00 56.55  ? 142 MET B CB  1 
ATOM   1487 C CG  . MET B 2 120 ? 139.470 150.150 145.515 1.00 56.55  ? 142 MET B CG  1 
ATOM   1488 S SD  . MET B 2 120 ? 137.765 149.898 146.034 1.00 56.55  ? 142 MET B SD  1 
ATOM   1489 C CE  . MET B 2 120 ? 137.469 151.404 146.955 1.00 56.55  ? 142 MET B CE  1 
ATOM   1490 N N   . LEU B 2 121 ? 142.355 151.225 144.098 1.00 57.02  ? 143 LEU B N   1 
ATOM   1491 C CA  . LEU B 2 121 ? 142.614 152.208 143.056 1.00 57.02  ? 143 LEU B CA  1 
ATOM   1492 C C   . LEU B 2 121 ? 141.509 152.133 142.014 1.00 57.02  ? 143 LEU B C   1 
ATOM   1493 O O   . LEU B 2 121 ? 141.237 151.059 141.469 1.00 57.02  ? 143 LEU B O   1 
ATOM   1494 C CB  . LEU B 2 121 ? 143.978 151.972 142.403 1.00 57.02  ? 143 LEU B CB  1 
ATOM   1495 C CG  . LEU B 2 121 ? 144.319 152.858 141.204 1.00 57.02  ? 143 LEU B CG  1 
ATOM   1496 C CD1 . LEU B 2 121 ? 144.384 154.318 141.621 1.00 57.02  ? 143 LEU B CD1 1 
ATOM   1497 C CD2 . LEU B 2 121 ? 145.628 152.422 140.564 1.00 57.02  ? 143 LEU B CD2 1 
ATOM   1498 N N   . CYS B 2 122 ? 140.878 153.271 141.738 1.00 61.34  ? 144 CYS B N   1 
ATOM   1499 C CA  . CYS B 2 122 ? 139.783 153.348 140.783 1.00 61.34  ? 144 CYS B CA  1 
ATOM   1500 C C   . CYS B 2 122 ? 140.156 154.276 139.636 1.00 61.34  ? 144 CYS B C   1 
ATOM   1501 O O   . CYS B 2 122 ? 140.877 155.260 139.820 1.00 61.34  ? 144 CYS B O   1 
ATOM   1502 C CB  . CYS B 2 122 ? 138.494 153.836 141.454 1.00 61.34  ? 144 CYS B CB  1 
ATOM   1503 S SG  . CYS B 2 122 ? 137.920 152.786 142.809 1.00 61.34  ? 144 CYS B SG  1 
ATOM   1504 N N   . GLN B 2 123 ? 139.657 153.950 138.446 1.00 60.83  ? 145 GLN B N   1 
ATOM   1505 C CA  . GLN B 2 123 ? 139.946 154.723 137.248 1.00 60.83  ? 145 GLN B CA  1 
ATOM   1506 C C   . GLN B 2 123 ? 138.674 154.880 136.429 1.00 60.83  ? 145 GLN B C   1 
ATOM   1507 O O   . GLN B 2 123 ? 137.733 154.091 136.544 1.00 60.83  ? 145 GLN B O   1 
ATOM   1508 C CB  . GLN B 2 123 ? 141.045 154.065 136.403 1.00 60.83  ? 145 GLN B CB  1 
ATOM   1509 C CG  . GLN B 2 123 ? 140.686 152.682 135.888 1.00 60.83  ? 145 GLN B CG  1 
ATOM   1510 C CD  . GLN B 2 123 ? 141.436 151.579 136.608 1.00 60.83  ? 145 GLN B CD  1 
ATOM   1511 O OE1 . GLN B 2 123 ? 142.114 151.823 137.605 1.00 60.83  ? 145 GLN B OE1 1 
ATOM   1512 N NE2 . GLN B 2 123 ? 141.314 150.355 136.106 1.00 60.83  ? 145 GLN B NE2 1 
ATOM   1513 N N   . TRP B 2 124 ? 138.659 155.915 135.593 1.00 63.89  ? 146 TRP B N   1 
ATOM   1514 C CA  . TRP B 2 124 ? 137.517 156.199 134.735 1.00 63.89  ? 146 TRP B CA  1 
ATOM   1515 C C   . TRP B 2 124 ? 137.988 157.062 133.574 1.00 63.89  ? 146 TRP B C   1 
ATOM   1516 O O   . TRP B 2 124 ? 139.102 157.591 133.580 1.00 63.89  ? 146 TRP B O   1 
ATOM   1517 C CB  . TRP B 2 124 ? 136.389 156.890 135.510 1.00 63.89  ? 146 TRP B CB  1 
ATOM   1518 C CG  . TRP B 2 124 ? 136.768 158.231 136.069 1.00 63.89  ? 146 TRP B CG  1 
ATOM   1519 C CD1 . TRP B 2 124 ? 136.744 159.428 135.415 1.00 63.89  ? 146 TRP B CD1 1 
ATOM   1520 C CD2 . TRP B 2 124 ? 137.217 158.511 137.401 1.00 63.89  ? 146 TRP B CD2 1 
ATOM   1521 N NE1 . TRP B 2 124 ? 137.156 160.435 136.254 1.00 63.89  ? 146 TRP B NE1 1 
ATOM   1522 C CE2 . TRP B 2 124 ? 137.451 159.898 137.480 1.00 63.89  ? 146 TRP B CE2 1 
ATOM   1523 C CE3 . TRP B 2 124 ? 137.445 157.725 138.534 1.00 63.89  ? 146 TRP B CE3 1 
ATOM   1524 C CZ2 . TRP B 2 124 ? 137.901 160.514 138.645 1.00 63.89  ? 146 TRP B CZ2 1 
ATOM   1525 C CZ3 . TRP B 2 124 ? 137.892 158.339 139.690 1.00 63.89  ? 146 TRP B CZ3 1 
ATOM   1526 C CH2 . TRP B 2 124 ? 138.114 159.720 139.737 1.00 63.89  ? 146 TRP B CH2 1 
ATOM   1527 N N   . ASP B 2 125 ? 137.123 157.194 132.569 1.00 67.46  ? 147 ASP B N   1 
ATOM   1528 C CA  . ASP B 2 125 ? 137.542 158.100 131.509 1.00 67.46  ? 147 ASP B CA  1 
ATOM   1529 C C   . ASP B 2 125 ? 136.799 159.426 131.617 1.00 67.46  ? 147 ASP B C   1 
ATOM   1530 O O   . ASP B 2 125 ? 135.603 159.446 131.928 1.00 67.46  ? 147 ASP B O   1 
ATOM   1531 C CB  . ASP B 2 125 ? 137.293 157.485 130.130 1.00 67.46  ? 147 ASP B CB  1 
ATOM   1532 C CG  . ASP B 2 125 ? 135.823 157.255 129.847 1.00 67.46  ? 147 ASP B CG  1 
ATOM   1533 O OD1 . ASP B 2 125 ? 135.076 156.938 130.795 1.00 67.46  ? 147 ASP B OD1 1 
ATOM   1534 O OD2 . ASP B 2 125 ? 135.414 157.389 128.675 1.00 67.46  ? 147 ASP B OD2 1 
ATOM   1535 N N   . PRO B 2 126 ? 137.478 160.547 131.376 1.00 66.79  ? 148 PRO B N   1 
ATOM   1536 C CA  . PRO B 2 126 ? 136.823 161.852 131.540 1.00 66.79  ? 148 PRO B CA  1 
ATOM   1537 C C   . PRO B 2 126 ? 135.866 162.177 130.405 1.00 66.79  ? 148 PRO B C   1 
ATOM   1538 O O   . PRO B 2 126 ? 134.814 162.785 130.627 1.00 66.79  ? 148 PRO B O   1 
ATOM   1539 C CB  . PRO B 2 126 ? 138.004 162.828 131.580 1.00 66.79  ? 148 PRO B CB  1 
ATOM   1540 C CG  . PRO B 2 126 ? 139.064 162.158 130.776 1.00 66.79  ? 148 PRO B CG  1 
ATOM   1541 C CD  . PRO B 2 126 ? 138.894 160.677 130.989 1.00 66.79  ? 148 PRO B CD  1 
ATOM   1542 N N   . GLY B 2 127 ? 136.216 161.774 129.187 1.00 72.93  ? 149 GLY B N   1 
ATOM   1543 C CA  . GLY B 2 127 ? 135.392 162.065 128.031 1.00 72.93  ? 149 GLY B CA  1 
ATOM   1544 C C   . GLY B 2 127 ? 135.997 163.110 127.117 1.00 72.93  ? 149 GLY B C   1 
ATOM   1545 O O   . GLY B 2 127 ? 137.024 162.866 126.477 1.00 72.93  ? 149 GLY B O   1 
ATOM   1546 N N   . ARG B 2 128 ? 135.371 164.280 127.048 1.00 82.30  ? 150 ARG B N   1 
ATOM   1547 C CA  . ARG B 2 128 ? 135.822 165.363 126.188 1.00 82.30  ? 150 ARG B CA  1 
ATOM   1548 C C   . ARG B 2 128 ? 136.553 166.429 126.997 1.00 82.30  ? 150 ARG B C   1 
ATOM   1549 O O   . ARG B 2 128 ? 136.425 166.516 128.220 1.00 82.30  ? 150 ARG B O   1 
ATOM   1550 C CB  . ARG B 2 128 ? 134.640 165.992 125.446 1.00 82.30  ? 150 ARG B CB  1 
ATOM   1551 C CG  . ARG B 2 128 ? 133.636 166.682 126.354 1.00 82.30  ? 150 ARG B CG  1 
ATOM   1552 C CD  . ARG B 2 128 ? 132.478 167.256 125.557 1.00 82.30  ? 150 ARG B CD  1 
ATOM   1553 N NE  . ARG B 2 128 ? 131.794 166.231 124.775 1.00 82.30  ? 150 ARG B NE  1 
ATOM   1554 C CZ  . ARG B 2 128 ? 130.734 166.461 124.006 1.00 82.30  ? 150 ARG B CZ  1 
ATOM   1555 N NH1 . ARG B 2 128 ? 130.177 165.467 123.329 1.00 82.30  ? 150 ARG B NH1 1 
ATOM   1556 N NH2 . ARG B 2 128 ? 130.231 167.685 123.916 1.00 82.30  ? 150 ARG B NH2 1 
ATOM   1557 N N   . GLU B 2 129 ? 137.329 167.245 126.287 1.00 83.01  ? 151 GLU B N   1 
ATOM   1558 C CA  . GLU B 2 129 ? 138.053 168.343 126.911 1.00 83.01  ? 151 GLU B CA  1 
ATOM   1559 C C   . GLU B 2 129 ? 137.124 169.535 127.097 1.00 83.01  ? 151 GLU B C   1 
ATOM   1560 O O   . GLU B 2 129 ? 136.515 170.014 126.135 1.00 83.01  ? 151 GLU B O   1 
ATOM   1561 C CB  . GLU B 2 129 ? 139.261 168.736 126.062 1.00 83.01  ? 151 GLU B CB  1 
ATOM   1562 C CG  . GLU B 2 129 ? 140.066 169.905 126.611 1.00 83.01  ? 151 GLU B CG  1 
ATOM   1563 C CD  . GLU B 2 129 ? 140.956 169.514 127.777 1.00 83.01  ? 151 GLU B CD  1 
ATOM   1564 O OE1 . GLU B 2 129 ? 140.423 169.193 128.860 1.00 83.01  ? 151 GLU B OE1 1 
ATOM   1565 O OE2 . GLU B 2 129 ? 142.193 169.527 127.609 1.00 83.01  ? 151 GLU B OE2 1 
ATOM   1566 N N   . THR B 2 130 ? 137.017 170.015 128.335 1.00 80.55  ? 152 THR B N   1 
ATOM   1567 C CA  . THR B 2 130 ? 136.113 171.108 128.667 1.00 80.55  ? 152 THR B CA  1 
ATOM   1568 C C   . THR B 2 130 ? 136.776 172.478 128.615 1.00 80.55  ? 152 THR B C   1 
ATOM   1569 O O   . THR B 2 130 ? 136.069 173.489 128.675 1.00 80.55  ? 152 THR B O   1 
ATOM   1570 C CB  . THR B 2 130 ? 135.513 170.893 130.060 1.00 80.55  ? 152 THR B CB  1 
ATOM   1571 O OG1 . THR B 2 130 ? 134.502 171.879 130.304 1.00 80.55  ? 152 THR B OG1 1 
ATOM   1572 C CG2 . THR B 2 130 ? 136.591 171.004 131.125 1.00 80.55  ? 152 THR B CG2 1 
ATOM   1573 N N   . TYR B 2 131 ? 138.105 172.533 128.516 1.00 83.20  ? 153 TYR B N   1 
ATOM   1574 C CA  . TYR B 2 131 ? 138.871 173.778 128.454 1.00 83.20  ? 153 TYR B CA  1 
ATOM   1575 C C   . TYR B 2 131 ? 138.682 174.645 129.695 1.00 83.20  ? 153 TYR B C   1 
ATOM   1576 O O   . TYR B 2 131 ? 138.875 175.864 129.638 1.00 83.20  ? 153 TYR B O   1 
ATOM   1577 C CB  . TYR B 2 131 ? 138.530 174.586 127.195 1.00 83.20  ? 153 TYR B CB  1 
ATOM   1578 C CG  . TYR B 2 131 ? 138.580 173.785 125.914 1.00 83.20  ? 153 TYR B CG  1 
ATOM   1579 C CD1 . TYR B 2 131 ? 139.790 173.501 125.295 1.00 83.20  ? 153 TYR B CD1 1 
ATOM   1580 C CD2 . TYR B 2 131 ? 137.415 173.317 125.319 1.00 83.20  ? 153 TYR B CD2 1 
ATOM   1581 C CE1 . TYR B 2 131 ? 139.839 172.770 124.123 1.00 83.20  ? 153 TYR B CE1 1 
ATOM   1582 C CE2 . TYR B 2 131 ? 137.455 172.586 124.148 1.00 83.20  ? 153 TYR B CE2 1 
ATOM   1583 C CZ  . TYR B 2 131 ? 138.669 172.315 123.554 1.00 83.20  ? 153 TYR B CZ  1 
ATOM   1584 O OH  . TYR B 2 131 ? 138.711 171.588 122.388 1.00 83.20  ? 153 TYR B OH  1 
ATOM   1585 N N   . LEU B 2 132 ? 138.307 174.043 130.822 1.00 79.75  ? 154 LEU B N   1 
ATOM   1586 C CA  . LEU B 2 132 ? 138.115 174.771 132.068 1.00 79.75  ? 154 LEU B CA  1 
ATOM   1587 C C   . LEU B 2 132 ? 138.659 173.939 133.221 1.00 79.75  ? 154 LEU B C   1 
ATOM   1588 O O   . LEU B 2 132 ? 138.924 172.742 133.084 1.00 79.75  ? 154 LEU B O   1 
ATOM   1589 C CB  . LEU B 2 132 ? 136.638 175.112 132.303 1.00 79.75  ? 154 LEU B CB  1 
ATOM   1590 C CG  . LEU B 2 132 ? 136.030 176.191 131.405 1.00 79.75  ? 154 LEU B CG  1 
ATOM   1591 C CD1 . LEU B 2 132 ? 134.544 176.344 131.681 1.00 79.75  ? 154 LEU B CD1 1 
ATOM   1592 C CD2 . LEU B 2 132 ? 136.753 177.512 131.602 1.00 79.75  ? 154 LEU B CD2 1 
ATOM   1593 N N   . GLU B 2 133 ? 138.826 174.591 134.369 1.00 79.67  ? 155 GLU B N   1 
ATOM   1594 C CA  . GLU B 2 133 ? 139.297 173.904 135.565 1.00 79.67  ? 155 GLU B CA  1 
ATOM   1595 C C   . GLU B 2 133 ? 138.188 173.017 136.118 1.00 79.67  ? 155 GLU B C   1 
ATOM   1596 O O   . GLU B 2 133 ? 137.134 173.512 136.529 1.00 79.67  ? 155 GLU B O   1 
ATOM   1597 C CB  . GLU B 2 133 ? 139.749 174.917 136.613 1.00 79.67  ? 155 GLU B CB  1 
ATOM   1598 C CG  . GLU B 2 133 ? 140.281 174.293 137.893 1.00 79.67  ? 155 GLU B CG  1 
ATOM   1599 C CD  . GLU B 2 133 ? 141.769 174.001 137.830 1.00 79.67  ? 155 GLU B CD  1 
ATOM   1600 O OE1 . GLU B 2 133 ? 142.390 173.845 138.902 1.00 79.67  ? 155 GLU B OE1 1 
ATOM   1601 O OE2 . GLU B 2 133 ? 142.318 173.928 136.710 1.00 79.67  ? 155 GLU B OE2 1 
ATOM   1602 N N   . THR B 2 134 ? 138.427 171.707 136.131 1.00 73.01  ? 156 THR B N   1 
ATOM   1603 C CA  . THR B 2 134 ? 137.436 170.732 136.565 1.00 73.01  ? 156 THR B CA  1 
ATOM   1604 C C   . THR B 2 134 ? 138.055 169.820 137.613 1.00 73.01  ? 156 THR B C   1 
ATOM   1605 O O   . THR B 2 134 ? 139.166 169.315 137.421 1.00 73.01  ? 156 THR B O   1 
ATOM   1606 C CB  . THR B 2 134 ? 136.919 169.906 135.381 1.00 73.01  ? 156 THR B CB  1 
ATOM   1607 O OG1 . THR B 2 134 ? 136.327 170.778 134.410 1.00 73.01  ? 156 THR B OG1 1 
ATOM   1608 C CG2 . THR B 2 134 ? 135.881 168.898 135.843 1.00 73.01  ? 156 THR B CG2 1 
ATOM   1609 N N   . ASN B 2 135 ? 137.340 169.614 138.715 1.00 72.11  ? 157 ASN B N   1 
ATOM   1610 C CA  . ASN B 2 135 ? 137.777 168.735 139.789 1.00 72.11  ? 157 ASN B CA  1 
ATOM   1611 C C   . ASN B 2 135 ? 136.962 167.450 139.770 1.00 72.11  ? 157 ASN B C   1 
ATOM   1612 O O   . ASN B 2 135 ? 135.749 167.475 139.542 1.00 72.11  ? 157 ASN B O   1 
ATOM   1613 C CB  . ASN B 2 135 ? 137.638 169.413 141.154 1.00 72.11  ? 157 ASN B CB  1 
ATOM   1614 C CG  . ASN B 2 135 ? 138.563 170.601 141.314 1.00 72.11  ? 157 ASN B CG  1 
ATOM   1615 O OD1 . ASN B 2 135 ? 139.428 170.848 140.475 1.00 72.11  ? 157 ASN B OD1 1 
ATOM   1616 N ND2 . ASN B 2 135 ? 138.386 171.342 142.401 1.00 72.11  ? 157 ASN B ND2 1 
ATOM   1617 N N   . TYR B 2 136 ? 137.635 166.329 140.013 1.00 64.37  ? 158 TYR B N   1 
ATOM   1618 C CA  . TYR B 2 136 ? 137.005 165.016 140.047 1.00 64.37  ? 158 TYR B CA  1 
ATOM   1619 C C   . TYR B 2 136 ? 137.154 164.435 141.446 1.00 64.37  ? 158 TYR B C   1 
ATOM   1620 O O   . TYR B 2 136 ? 138.277 164.226 141.918 1.00 64.37  ? 158 TYR B O   1 
ATOM   1621 C CB  . TYR B 2 136 ? 137.623 164.085 139.005 1.00 64.37  ? 158 TYR B CB  1 
ATOM   1622 C CG  . TYR B 2 136 ? 137.221 164.409 137.584 1.00 64.37  ? 158 TYR B CG  1 
ATOM   1623 C CD1 . TYR B 2 136 ? 136.114 163.806 137.002 1.00 64.37  ? 158 TYR B CD1 1 
ATOM   1624 C CD2 . TYR B 2 136 ? 137.945 165.319 136.827 1.00 64.37  ? 158 TYR B CD2 1 
ATOM   1625 C CE1 . TYR B 2 136 ? 135.742 164.099 135.705 1.00 64.37  ? 158 TYR B CE1 1 
ATOM   1626 C CE2 . TYR B 2 136 ? 137.579 165.618 135.530 1.00 64.37  ? 158 TYR B CE2 1 
ATOM   1627 C CZ  . TYR B 2 136 ? 136.477 165.006 134.974 1.00 64.37  ? 158 TYR B CZ  1 
ATOM   1628 O OH  . TYR B 2 136 ? 136.108 165.300 133.682 1.00 64.37  ? 158 TYR B OH  1 
ATOM   1629 N N   . THR B 2 137 ? 136.026 164.178 142.103 1.00 57.96  ? 159 THR B N   1 
ATOM   1630 C CA  . THR B 2 137 ? 135.998 163.644 143.458 1.00 57.96  ? 159 THR B CA  1 
ATOM   1631 C C   . THR B 2 137 ? 135.323 162.280 143.444 1.00 57.96  ? 159 THR B C   1 
ATOM   1632 O O   . THR B 2 137 ? 134.223 162.135 142.902 1.00 57.96  ? 159 THR B O   1 
ATOM   1633 C CB  . THR B 2 137 ? 135.259 164.590 144.409 1.00 57.96  ? 159 THR B CB  1 
ATOM   1634 O OG1 . THR B 2 137 ? 135.967 165.832 144.497 1.00 57.96  ? 159 THR B OG1 1 
ATOM   1635 C CG2 . THR B 2 137 ? 135.149 163.978 145.795 1.00 57.96  ? 159 THR B CG2 1 
ATOM   1636 N N   . LEU B 2 138 ? 135.981 161.288 144.038 1.00 54.34  ? 160 LEU B N   1 
ATOM   1637 C CA  . LEU B 2 138 ? 135.456 159.931 144.111 1.00 54.34  ? 160 LEU B CA  1 
ATOM   1638 C C   . LEU B 2 138 ? 134.828 159.709 145.481 1.00 54.34  ? 160 LEU B C   1 
ATOM   1639 O O   . LEU B 2 138 ? 135.500 159.856 146.508 1.00 54.34  ? 160 LEU B O   1 
ATOM   1640 C CB  . LEU B 2 138 ? 136.557 158.903 143.854 1.00 54.34  ? 160 LEU B CB  1 
ATOM   1641 C CG  . LEU B 2 138 ? 136.153 157.438 144.026 1.00 54.34  ? 160 LEU B CG  1 
ATOM   1642 C CD1 . LEU B 2 138 ? 135.066 157.063 143.031 1.00 54.34  ? 160 LEU B CD1 1 
ATOM   1643 C CD2 . LEU B 2 138 ? 137.360 156.526 143.874 1.00 54.34  ? 160 LEU B CD2 1 
ATOM   1644 N N   . LYS B 2 139 ? 133.549 159.355 145.493 1.00 50.97  ? 161 LYS B N   1 
ATOM   1645 C CA  . LYS B 2 139 ? 132.820 159.078 146.720 1.00 50.97  ? 161 LYS B CA  1 
ATOM   1646 C C   . LYS B 2 139 ? 132.866 157.588 147.038 1.00 50.97  ? 161 LYS B C   1 
ATOM   1647 O O   . LYS B 2 139 ? 133.076 156.747 146.162 1.00 50.97  ? 161 LYS B O   1 
ATOM   1648 C CB  . LYS B 2 139 ? 131.368 159.546 146.606 1.00 50.97  ? 161 LYS B CB  1 
ATOM   1649 C CG  . LYS B 2 139 ? 131.215 161.047 146.438 1.00 50.97  ? 161 LYS B CG  1 
ATOM   1650 C CD  . LYS B 2 139 ? 131.719 161.790 147.663 1.00 50.97  ? 161 LYS B CD  1 
ATOM   1651 C CE  . LYS B 2 139 ? 131.516 163.288 147.523 1.00 50.97  ? 161 LYS B CE  1 
ATOM   1652 N NZ  . LYS B 2 139 ? 131.960 164.022 148.740 1.00 50.97  ? 161 LYS B NZ  1 
ATOM   1653 N N   . SER B 2 140 ? 132.666 157.271 148.315 1.00 50.31  ? 162 SER B N   1 
ATOM   1654 C CA  . SER B 2 140 ? 132.695 155.889 148.772 1.00 50.31  ? 162 SER B CA  1 
ATOM   1655 C C   . SER B 2 140 ? 131.960 155.796 150.099 1.00 50.31  ? 162 SER B C   1 
ATOM   1656 O O   . SER B 2 140 ? 132.110 156.669 150.956 1.00 50.31  ? 162 SER B O   1 
ATOM   1657 C CB  . SER B 2 140 ? 134.133 155.384 148.922 1.00 50.31  ? 162 SER B CB  1 
ATOM   1658 O OG  . SER B 2 140 ? 134.177 154.200 149.696 1.00 50.31  ? 162 SER B OG  1 
ATOM   1659 N N   . GLU B 2 141 ? 131.174 154.734 150.263 1.00 46.90  ? 163 GLU B N   1 
ATOM   1660 C CA  . GLU B 2 141 ? 130.411 154.545 151.488 1.00 46.90  ? 163 GLU B CA  1 
ATOM   1661 C C   . GLU B 2 141 ? 129.917 153.109 151.565 1.00 46.90  ? 163 GLU B C   1 
ATOM   1662 O O   . GLU B 2 141 ? 129.748 152.439 150.543 1.00 46.90  ? 163 GLU B O   1 
ATOM   1663 C CB  . GLU B 2 141 ? 129.224 155.512 151.565 1.00 46.90  ? 163 GLU B CB  1 
ATOM   1664 C CG  . GLU B 2 141 ? 128.135 155.238 150.542 1.00 46.90  ? 163 GLU B CG  1 
ATOM   1665 C CD  . GLU B 2 141 ? 126.875 156.040 150.801 1.00 46.90  ? 163 GLU B CD  1 
ATOM   1666 O OE1 . GLU B 2 141 ? 126.904 156.931 151.675 1.00 46.90  ? 163 GLU B OE1 1 
ATOM   1667 O OE2 . GLU B 2 141 ? 125.855 155.779 150.130 1.00 46.90  ? 163 GLU B OE2 1 
ATOM   1668 N N   . TRP B 2 142 ? 129.693 152.649 152.792 1.00 44.66  ? 164 TRP B N   1 
ATOM   1669 C CA  . TRP B 2 142 ? 129.062 151.365 153.049 1.00 44.66  ? 164 TRP B CA  1 
ATOM   1670 C C   . TRP B 2 142 ? 127.546 151.546 153.064 1.00 44.66  ? 164 TRP B C   1 
ATOM   1671 O O   . TRP B 2 142 ? 127.017 152.582 152.653 1.00 44.66  ? 164 TRP B O   1 
ATOM   1672 C CB  . TRP B 2 142 ? 129.557 150.774 154.367 1.00 44.66  ? 164 TRP B CB  1 
ATOM   1673 C CG  . TRP B 2 142 ? 130.888 150.104 154.290 1.00 44.66  ? 164 TRP B CG  1 
ATOM   1674 C CD1 . TRP B 2 142 ? 131.658 149.931 153.180 1.00 44.66  ? 164 TRP B CD1 1 
ATOM   1675 C CD2 . TRP B 2 142 ? 131.608 149.509 155.376 1.00 44.66  ? 164 TRP B CD2 1 
ATOM   1676 N NE1 . TRP B 2 142 ? 132.816 149.267 153.507 1.00 44.66  ? 164 TRP B NE1 1 
ATOM   1677 C CE2 . TRP B 2 142 ? 132.809 148.997 154.850 1.00 44.66  ? 164 TRP B CE2 1 
ATOM   1678 C CE3 . TRP B 2 142 ? 131.354 149.363 156.743 1.00 44.66  ? 164 TRP B CE3 1 
ATOM   1679 C CZ2 . TRP B 2 142 ? 133.753 148.349 155.642 1.00 44.66  ? 164 TRP B CZ2 1 
ATOM   1680 C CZ3 . TRP B 2 142 ? 132.292 148.720 157.526 1.00 44.66  ? 164 TRP B CZ3 1 
ATOM   1681 C CH2 . TRP B 2 142 ? 133.477 148.221 156.974 1.00 44.66  ? 164 TRP B CH2 1 
ATOM   1682 N N   . ALA B 2 143 ? 126.828 150.530 153.541 1.00 46.65  ? 165 ALA B N   1 
ATOM   1683 C CA  . ALA B 2 143 ? 125.390 150.659 153.733 1.00 46.65  ? 165 ALA B CA  1 
ATOM   1684 C C   . ALA B 2 143 ? 125.039 151.437 154.994 1.00 46.65  ? 165 ALA B C   1 
ATOM   1685 O O   . ALA B 2 143 ? 123.906 151.916 155.113 1.00 46.65  ? 165 ALA B O   1 
ATOM   1686 C CB  . ALA B 2 143 ? 124.737 149.277 153.783 1.00 46.65  ? 165 ALA B CB  1 
ATOM   1687 N N   . THR B 2 144 ? 125.978 151.570 155.934 1.00 47.77  ? 166 THR B N   1 
ATOM   1688 C CA  . THR B 2 144 ? 125.725 152.299 157.170 1.00 47.77  ? 166 THR B CA  1 
ATOM   1689 C C   . THR B 2 144 ? 126.844 153.252 157.564 1.00 47.77  ? 166 THR B C   1 
ATOM   1690 O O   . THR B 2 144 ? 126.730 153.901 158.609 1.00 47.77  ? 166 THR B O   1 
ATOM   1691 C CB  . THR B 2 144 ? 125.480 151.323 158.333 1.00 47.77  ? 166 THR B CB  1 
ATOM   1692 O OG1 . THR B 2 144 ? 126.541 150.362 158.386 1.00 47.77  ? 166 THR B OG1 1 
ATOM   1693 C CG2 . THR B 2 144 ? 124.153 150.603 158.165 1.00 47.77  ? 166 THR B CG2 1 
ATOM   1694 N N   . GLU B 2 145 ? 127.913 153.363 156.779 1.00 50.13  ? 167 GLU B N   1 
ATOM   1695 C CA  . GLU B 2 145 ? 129.039 154.214 157.131 1.00 50.13  ? 167 GLU B CA  1 
ATOM   1696 C C   . GLU B 2 145 ? 129.580 154.885 155.877 1.00 50.13  ? 167 GLU B C   1 
ATOM   1697 O O   . GLU B 2 145 ? 129.487 154.342 154.774 1.00 50.13  ? 167 GLU B O   1 
ATOM   1698 C CB  . GLU B 2 145 ? 130.152 153.414 157.823 1.00 50.13  ? 167 GLU B CB  1 
ATOM   1699 C CG  . GLU B 2 145 ? 131.139 154.265 158.605 1.00 50.13  ? 167 GLU B CG  1 
ATOM   1700 C CD  . GLU B 2 145 ? 132.250 153.445 159.230 1.00 50.13  ? 167 GLU B CD  1 
ATOM   1701 O OE1 . GLU B 2 145 ? 132.584 152.376 158.679 1.00 50.13  ? 167 GLU B OE1 1 
ATOM   1702 O OE2 . GLU B 2 145 ? 132.790 153.870 160.273 1.00 50.13  ? 167 GLU B OE2 1 
ATOM   1703 N N   . LYS B 2 146 ? 130.147 156.074 156.060 1.00 49.74  ? 168 LYS B N   1 
ATOM   1704 C CA  . LYS B 2 146 ? 130.729 156.848 154.976 1.00 49.74  ? 168 LYS B CA  1 
ATOM   1705 C C   . LYS B 2 146 ? 132.236 156.962 155.166 1.00 49.74  ? 168 LYS B C   1 
ATOM   1706 O O   . LYS B 2 146 ? 132.741 156.939 156.292 1.00 49.74  ? 168 LYS B O   1 
ATOM   1707 C CB  . LYS B 2 146 ? 130.105 158.244 154.899 1.00 49.74  ? 168 LYS B CB  1 
ATOM   1708 C CG  . LYS B 2 146 ? 128.599 158.237 154.700 1.00 49.74  ? 168 LYS B CG  1 
ATOM   1709 C CD  . LYS B 2 146 ? 128.044 159.649 154.640 1.00 49.74  ? 168 LYS B CD  1 
ATOM   1710 C CE  . LYS B 2 146 ? 126.536 159.641 154.452 1.00 49.74  ? 168 LYS B CE  1 
ATOM   1711 N NZ  . LYS B 2 146 ? 126.138 158.945 153.199 1.00 49.74  ? 168 LYS B NZ  1 
ATOM   1712 N N   . PHE B 2 147 ? 132.947 157.086 154.054 1.00 54.02  ? 169 PHE B N   1 
ATOM   1713 C CA  . PHE B 2 147 ? 134.398 157.133 154.025 1.00 54.02  ? 169 PHE B CA  1 
ATOM   1714 C C   . PHE B 2 147 ? 134.874 158.464 153.455 1.00 54.02  ? 169 PHE B C   1 
ATOM   1715 O O   . PHE B 2 147 ? 134.118 159.159 152.766 1.00 54.02  ? 169 PHE B O   1 
ATOM   1716 C CB  . PHE B 2 147 ? 134.955 155.973 153.187 1.00 54.02  ? 169 PHE B CB  1 
ATOM   1717 C CG  . PHE B 2 147 ? 134.874 154.639 153.872 1.00 54.02  ? 169 PHE B CG  1 
ATOM   1718 C CD1 . PHE B 2 147 ? 135.997 154.074 154.451 1.00 54.02  ? 169 PHE B CD1 1 
ATOM   1719 C CD2 . PHE B 2 147 ? 133.674 153.952 153.941 1.00 54.02  ? 169 PHE B CD2 1 
ATOM   1720 C CE1 . PHE B 2 147 ? 135.925 152.847 155.083 1.00 54.02  ? 169 PHE B CE1 1 
ATOM   1721 C CE2 . PHE B 2 147 ? 133.596 152.726 154.571 1.00 54.02  ? 169 PHE B CE2 1 
ATOM   1722 C CZ  . PHE B 2 147 ? 134.723 152.173 155.143 1.00 54.02  ? 169 PHE B CZ  1 
ATOM   1723 N N   . PRO B 2 148 ? 136.118 158.858 153.736 1.00 59.56  ? 170 PRO B N   1 
ATOM   1724 C CA  . PRO B 2 148 ? 136.638 160.115 153.183 1.00 59.56  ? 170 PRO B CA  1 
ATOM   1725 C C   . PRO B 2 148 ? 136.656 160.104 151.661 1.00 59.56  ? 170 PRO B C   1 
ATOM   1726 O O   . PRO B 2 148 ? 136.632 159.055 151.014 1.00 59.56  ? 170 PRO B O   1 
ATOM   1727 C CB  . PRO B 2 148 ? 138.058 160.195 153.755 1.00 59.56  ? 170 PRO B CB  1 
ATOM   1728 C CG  . PRO B 2 148 ? 138.007 159.378 154.997 1.00 59.56  ? 170 PRO B CG  1 
ATOM   1729 C CD  . PRO B 2 148 ? 137.049 158.261 154.710 1.00 59.56  ? 170 PRO B CD  1 
ATOM   1730 N N   . ASP B 2 149 ? 136.706 161.304 151.090 1.00 58.74  ? 171 ASP B N   1 
ATOM   1731 C CA  . ASP B 2 149 ? 136.631 161.482 149.649 1.00 58.74  ? 171 ASP B CA  1 
ATOM   1732 C C   . ASP B 2 149 ? 138.001 161.316 149.002 1.00 58.74  ? 171 ASP B C   1 
ATOM   1733 O O   . ASP B 2 149 ? 139.039 161.588 149.612 1.00 58.74  ? 171 ASP B O   1 
ATOM   1734 C CB  . ASP B 2 149 ? 136.062 162.858 149.303 1.00 58.74  ? 171 ASP B CB  1 
ATOM   1735 C CG  . ASP B 2 149 ? 134.774 163.157 150.040 1.00 58.74  ? 171 ASP B CG  1 
ATOM   1736 O OD1 . ASP B 2 149 ? 134.048 162.200 150.380 1.00 58.74  ? 171 ASP B OD1 1 
ATOM   1737 O OD2 . ASP B 2 149 ? 134.485 164.348 150.276 1.00 58.74  ? 171 ASP B OD2 1 
ATOM   1738 N N   . CYS B 2 150 ? 137.989 160.864 147.752 1.00 64.99  ? 172 CYS B N   1 
ATOM   1739 C CA  . CYS B 2 150 ? 139.193 160.676 146.946 1.00 64.99  ? 172 CYS B CA  1 
ATOM   1740 C C   . CYS B 2 150 ? 139.233 161.781 145.895 1.00 64.99  ? 172 CYS B C   1 
ATOM   1741 O O   . CYS B 2 150 ? 138.536 161.707 144.879 1.00 64.99  ? 172 CYS B O   1 
ATOM   1742 C CB  . CYS B 2 150 ? 139.203 159.295 146.300 1.00 64.99  ? 172 CYS B CB  1 
ATOM   1743 S SG  . CYS B 2 150 ? 140.808 158.762 145.659 1.00 64.99  ? 172 CYS B SG  1 
ATOM   1744 N N   . GLN B 2 151 ? 140.049 162.802 146.139 1.00 73.64  ? 173 GLN B N   1 
ATOM   1745 C CA  . GLN B 2 151 ? 140.181 163.922 145.216 1.00 73.64  ? 173 GLN B CA  1 
ATOM   1746 C C   . GLN B 2 151 ? 141.354 163.665 144.276 1.00 73.64  ? 173 GLN B C   1 
ATOM   1747 O O   . GLN B 2 151 ? 142.491 163.488 144.727 1.00 73.64  ? 173 GLN B O   1 
ATOM   1748 C CB  . GLN B 2 151 ? 140.372 165.233 145.977 1.00 73.64  ? 173 GLN B CB  1 
ATOM   1749 C CG  . GLN B 2 151 ? 140.309 166.465 145.095 1.00 73.64  ? 173 GLN B CG  1 
ATOM   1750 C CD  . GLN B 2 151 ? 140.264 167.751 145.894 1.00 73.64  ? 173 GLN B CD  1 
ATOM   1751 O OE1 . GLN B 2 151 ? 140.233 167.731 147.124 1.00 73.64  ? 173 GLN B OE1 1 
ATOM   1752 N NE2 . GLN B 2 151 ? 140.258 168.880 145.195 1.00 73.64  ? 173 GLN B NE2 1 
ATOM   1753 N N   . SER B 2 152 ? 141.074 163.643 142.975 1.00 78.99  ? 174 SER B N   1 
ATOM   1754 C CA  . SER B 2 152 ? 142.096 163.362 141.970 1.00 78.99  ? 174 SER B CA  1 
ATOM   1755 C C   . SER B 2 152 ? 143.080 164.523 141.900 1.00 78.99  ? 174 SER B C   1 
ATOM   1756 O O   . SER B 2 152 ? 142.714 165.635 141.504 1.00 78.99  ? 174 SER B O   1 
ATOM   1757 C CB  . SER B 2 152 ? 141.443 163.118 140.613 1.00 78.99  ? 174 SER B CB  1 
ATOM   1758 O OG  . SER B 2 152 ? 142.366 163.331 139.559 1.00 78.99  ? 174 SER B OG  1 
ATOM   1759 N N   . LYS B 2 153 ? 144.332 164.267 142.282 1.00 87.87  ? 175 LYS B N   1 
ATOM   1760 C CA  . LYS B 2 153 ? 145.344 165.317 142.236 1.00 87.87  ? 175 LYS B CA  1 
ATOM   1761 C C   . LYS B 2 153 ? 145.798 165.586 140.805 1.00 87.87  ? 175 LYS B C   1 
ATOM   1762 O O   . LYS B 2 153 ? 146.176 166.715 140.471 1.00 87.87  ? 175 LYS B O   1 
ATOM   1763 C CB  . LYS B 2 153 ? 146.531 164.946 143.128 1.00 87.87  ? 175 LYS B CB  1 
ATOM   1764 C CG  . LYS B 2 153 ? 147.435 163.856 142.570 1.00 87.87  ? 175 LYS B CG  1 
ATOM   1765 C CD  . LYS B 2 153 ? 148.852 163.985 143.108 1.00 87.87  ? 175 LYS B CD  1 
ATOM   1766 C CE  . LYS B 2 153 ? 149.547 165.220 142.560 1.00 87.87  ? 175 LYS B CE  1 
ATOM   1767 N NZ  . LYS B 2 153 ? 149.803 165.115 141.097 1.00 87.87  ? 175 LYS B NZ  1 
ATOM   1768 N N   . HIS B 2 154 ? 145.764 164.569 139.947 1.00 87.12  ? 176 HIS B N   1 
ATOM   1769 C CA  . HIS B 2 154 ? 146.192 164.727 138.566 1.00 87.12  ? 176 HIS B CA  1 
ATOM   1770 C C   . HIS B 2 154 ? 145.612 163.584 137.747 1.00 87.12  ? 176 HIS B C   1 
ATOM   1771 O O   . HIS B 2 154 ? 145.723 162.419 138.135 1.00 87.12  ? 176 HIS B O   1 
ATOM   1772 C CB  . HIS B 2 154 ? 147.722 164.740 138.463 1.00 87.12  ? 176 HIS B CB  1 
ATOM   1773 C CG  . HIS B 2 154 ? 148.242 165.104 137.106 1.00 87.12  ? 176 HIS B CG  1 
ATOM   1774 N ND1 . HIS B 2 154 ? 149.589 165.212 136.834 1.00 87.12  ? 176 HIS B ND1 1 
ATOM   1775 C CD2 . HIS B 2 154 ? 147.601 165.406 135.953 1.00 87.12  ? 176 HIS B CD2 1 
ATOM   1776 C CE1 . HIS B 2 154 ? 149.755 165.553 135.568 1.00 87.12  ? 176 HIS B CE1 1 
ATOM   1777 N NE2 . HIS B 2 154 ? 148.564 165.678 135.011 1.00 87.12  ? 176 HIS B NE2 1 
ATOM   1778 N N   . GLY B 2 155 ? 145.000 163.923 136.616 1.00 78.85  ? 177 GLY B N   1 
ATOM   1779 C CA  . GLY B 2 155 ? 144.463 162.913 135.727 1.00 78.85  ? 177 GLY B CA  1 
ATOM   1780 C C   . GLY B 2 155 ? 143.106 162.379 136.138 1.00 78.85  ? 177 GLY B C   1 
ATOM   1781 O O   . GLY B 2 155 ? 142.205 163.148 136.485 1.00 78.85  ? 177 GLY B O   1 
ATOM   1782 N N   . THR B 2 156 ? 142.949 161.054 136.103 1.00 70.26  ? 178 THR B N   1 
ATOM   1783 C CA  . THR B 2 156 ? 141.664 160.420 136.357 1.00 70.26  ? 178 THR B CA  1 
ATOM   1784 C C   . THR B 2 156 ? 141.676 159.404 137.487 1.00 70.26  ? 178 THR B C   1 
ATOM   1785 O O   . THR B 2 156 ? 140.615 159.145 138.063 1.00 70.26  ? 178 THR B O   1 
ATOM   1786 C CB  . THR B 2 156 ? 141.153 159.723 135.086 1.00 70.26  ? 178 THR B CB  1 
ATOM   1787 O OG1 . THR B 2 156 ? 142.097 158.728 134.672 1.00 70.26  ? 178 THR B OG1 1 
ATOM   1788 C CG2 . THR B 2 156 ? 140.970 160.732 133.967 1.00 70.26  ? 178 THR B CG2 1 
ATOM   1789 N N   . SER B 2 157 ? 142.821 158.815 137.814 1.00 69.88  ? 179 SER B N   1 
ATOM   1790 C CA  . SER B 2 157 ? 142.876 157.821 138.874 1.00 69.88  ? 179 SER B CA  1 
ATOM   1791 C C   . SER B 2 157 ? 143.361 158.445 140.177 1.00 69.88  ? 179 SER B C   1 
ATOM   1792 O O   . SER B 2 157 ? 144.220 159.331 140.187 1.00 69.88  ? 179 SER B O   1 
ATOM   1793 C CB  . SER B 2 157 ? 143.793 156.664 138.477 1.00 69.88  ? 179 SER B CB  1 
ATOM   1794 O OG  . SER B 2 157 ? 145.140 156.935 138.822 1.00 69.88  ? 179 SER B OG  1 
ATOM   1795 N N   . CYS B 2 158 ? 142.798 157.970 141.287 1.00 67.72  ? 180 CYS B N   1 
ATOM   1796 C CA  . CYS B 2 158 ? 143.213 158.413 142.612 1.00 67.72  ? 180 CYS B CA  1 
ATOM   1797 C C   . CYS B 2 158 ? 143.196 157.219 143.553 1.00 67.72  ? 180 CYS B C   1 
ATOM   1798 O O   . CYS B 2 158 ? 142.327 156.349 143.441 1.00 67.72  ? 180 CYS B O   1 
ATOM   1799 C CB  . CYS B 2 158 ? 142.303 159.523 143.153 1.00 67.72  ? 180 CYS B CB  1 
ATOM   1800 S SG  . CYS B 2 158 ? 140.651 158.987 143.644 1.00 67.72  ? 180 CYS B SG  1 
ATOM   1801 N N   . MET B 2 159 ? 144.159 157.176 144.468 1.00 64.02  ? 181 MET B N   1 
ATOM   1802 C CA  . MET B 2 159 ? 144.301 156.076 145.413 1.00 64.02  ? 181 MET B CA  1 
ATOM   1803 C C   . MET B 2 159 ? 143.672 156.474 146.744 1.00 64.02  ? 181 MET B C   1 
ATOM   1804 O O   . MET B 2 159 ? 143.986 157.538 147.288 1.00 64.02  ? 181 MET B O   1 
ATOM   1805 C CB  . MET B 2 159 ? 145.775 155.715 145.592 1.00 64.02  ? 181 MET B CB  1 
ATOM   1806 C CG  . MET B 2 159 ? 146.031 154.515 146.481 1.00 64.02  ? 181 MET B CG  1 
ATOM   1807 S SD  . MET B 2 159 ? 147.787 154.109 146.546 1.00 64.02  ? 181 MET B SD  1 
ATOM   1808 C CE  . MET B 2 159 ? 147.775 152.679 147.621 1.00 64.02  ? 181 MET B CE  1 
ATOM   1809 N N   . VAL B 2 160 ? 142.785 155.620 147.263 1.00 60.17  ? 182 VAL B N   1 
ATOM   1810 C CA  . VAL B 2 160 ? 142.120 155.923 148.528 1.00 60.17  ? 182 VAL B CA  1 
ATOM   1811 C C   . VAL B 2 160 ? 143.118 155.849 149.680 1.00 60.17  ? 182 VAL B C   1 
ATOM   1812 O O   . VAL B 2 160 ? 144.220 155.301 149.562 1.00 60.17  ? 182 VAL B O   1 
ATOM   1813 C CB  . VAL B 2 160 ? 140.928 154.982 148.767 1.00 60.17  ? 182 VAL B CB  1 
ATOM   1814 C CG1 . VAL B 2 160 ? 139.868 155.188 147.697 1.00 60.17  ? 182 VAL B CG1 1 
ATOM   1815 C CG2 . VAL B 2 160 ? 141.389 153.536 148.803 1.00 60.17  ? 182 VAL B CG2 1 
ATOM   1816 N N   . SER B 2 161 ? 142.713 156.410 150.821 1.00 60.95  ? 183 SER B N   1 
ATOM   1817 C CA  . SER B 2 161 ? 143.590 156.517 151.979 1.00 60.95  ? 183 SER B CA  1 
ATOM   1818 C C   . SER B 2 161 ? 143.324 155.473 153.056 1.00 60.95  ? 183 SER B C   1 
ATOM   1819 O O   . SER B 2 161 ? 144.219 155.208 153.866 1.00 60.95  ? 183 SER B O   1 
ATOM   1820 C CB  . SER B 2 161 ? 143.471 157.913 152.605 1.00 60.95  ? 183 SER B CB  1 
ATOM   1821 O OG  . SER B 2 161 ? 142.180 158.116 153.152 1.00 60.95  ? 183 SER B OG  1 
ATOM   1822 N N   . TYR B 2 162 ? 142.135 154.880 153.091 1.00 59.63  ? 184 TYR B N   1 
ATOM   1823 C CA  . TYR B 2 162 ? 141.788 153.932 154.140 1.00 59.63  ? 184 TYR B CA  1 
ATOM   1824 C C   . TYR B 2 162 ? 142.176 152.508 153.746 1.00 59.63  ? 184 TYR B C   1 
ATOM   1825 O O   . TYR B 2 162 ? 142.478 152.214 152.587 1.00 59.63  ? 184 TYR B O   1 
ATOM   1826 C CB  . TYR B 2 162 ? 140.293 154.001 154.462 1.00 59.63  ? 184 TYR B CB  1 
ATOM   1827 C CG  . TYR B 2 162 ? 139.382 153.926 153.256 1.00 59.63  ? 184 TYR B CG  1 
ATOM   1828 C CD1 . TYR B 2 162 ? 138.913 155.081 152.642 1.00 59.63  ? 184 TYR B CD1 1 
ATOM   1829 C CD2 . TYR B 2 162 ? 138.983 152.702 152.736 1.00 59.63  ? 184 TYR B CD2 1 
ATOM   1830 C CE1 . TYR B 2 162 ? 138.079 155.017 151.542 1.00 59.63  ? 184 TYR B CE1 1 
ATOM   1831 C CE2 . TYR B 2 162 ? 138.150 152.630 151.637 1.00 59.63  ? 184 TYR B CE2 1 
ATOM   1832 C CZ  . TYR B 2 162 ? 137.701 153.790 151.044 1.00 59.63  ? 184 TYR B CZ  1 
ATOM   1833 O OH  . TYR B 2 162 ? 136.871 153.721 149.950 1.00 59.63  ? 184 TYR B OH  1 
ATOM   1834 N N   . MET B 2 163 ? 142.168 151.618 154.746 1.00 62.32  ? 185 MET B N   1 
ATOM   1835 C CA  . MET B 2 163 ? 142.487 150.211 154.541 1.00 62.32  ? 185 MET B CA  1 
ATOM   1836 C C   . MET B 2 163 ? 141.278 149.475 153.965 1.00 62.32  ? 185 MET B C   1 
ATOM   1837 O O   . MET B 2 163 ? 140.146 149.707 154.398 1.00 62.32  ? 185 MET B O   1 
ATOM   1838 C CB  . MET B 2 163 ? 142.907 149.555 155.856 1.00 62.32  ? 185 MET B CB  1 
ATOM   1839 C CG  . MET B 2 163 ? 144.397 149.614 156.161 1.00 62.32  ? 185 MET B CG  1 
ATOM   1840 S SD  . MET B 2 163 ? 145.415 148.672 155.006 1.00 62.32  ? 185 MET B SD  1 
ATOM   1841 C CE  . MET B 2 163 ? 146.264 149.992 154.143 1.00 62.32  ? 185 MET B CE  1 
ATOM   1842 N N   . PRO B 2 164 ? 141.487 148.584 152.998 1.00 55.55  ? 186 PRO B N   1 
ATOM   1843 C CA  . PRO B 2 164 ? 140.355 147.850 152.423 1.00 55.55  ? 186 PRO B CA  1 
ATOM   1844 C C   . PRO B 2 164 ? 139.850 146.776 153.373 1.00 55.55  ? 186 PRO B C   1 
ATOM   1845 O O   . PRO B 2 164 ? 140.629 146.019 153.958 1.00 55.55  ? 186 PRO B O   1 
ATOM   1846 C CB  . PRO B 2 164 ? 140.943 147.238 151.148 1.00 55.55  ? 186 PRO B CB  1 
ATOM   1847 C CG  . PRO B 2 164 ? 142.393 147.079 151.456 1.00 55.55  ? 186 PRO B CG  1 
ATOM   1848 C CD  . PRO B 2 164 ? 142.765 148.229 152.356 1.00 55.55  ? 186 PRO B CD  1 
ATOM   1849 N N   . THR B 2 165 ? 138.531 146.719 153.526 1.00 49.45  ? 187 THR B N   1 
ATOM   1850 C CA  . THR B 2 165 ? 137.870 145.718 154.353 1.00 49.45  ? 187 THR B CA  1 
ATOM   1851 C C   . THR B 2 165 ? 137.127 144.742 153.453 1.00 49.45  ? 187 THR B C   1 
ATOM   1852 O O   . THR B 2 165 ? 136.358 145.159 152.580 1.00 49.45  ? 187 THR B O   1 
ATOM   1853 C CB  . THR B 2 165 ? 136.903 146.371 155.343 1.00 49.45  ? 187 THR B CB  1 
ATOM   1854 O OG1 . THR B 2 165 ? 137.618 147.301 156.165 1.00 49.45  ? 187 THR B OG1 1 
ATOM   1855 C CG2 . THR B 2 165 ? 136.260 145.317 156.229 1.00 49.45  ? 187 THR B CG2 1 
ATOM   1856 N N   . TYR B 2 166 ? 137.358 143.452 153.665 1.00 44.80  ? 188 TYR B N   1 
ATOM   1857 C CA  . TYR B 2 166 ? 136.799 142.419 152.807 1.00 44.80  ? 188 TYR B CA  1 
ATOM   1858 C C   . TYR B 2 166 ? 135.449 141.939 153.330 1.00 44.80  ? 188 TYR B C   1 
ATOM   1859 O O   . TYR B 2 166 ? 135.059 142.213 154.467 1.00 44.80  ? 188 TYR B O   1 
ATOM   1860 C CB  . TYR B 2 166 ? 137.768 141.243 152.692 1.00 44.80  ? 188 TYR B CB  1 
ATOM   1861 C CG  . TYR B 2 166 ? 139.151 141.644 152.236 1.00 44.80  ? 188 TYR B CG  1 
ATOM   1862 C CD1 . TYR B 2 166 ? 139.444 141.786 150.887 1.00 44.80  ? 188 TYR B CD1 1 
ATOM   1863 C CD2 . TYR B 2 166 ? 140.163 141.887 153.154 1.00 44.80  ? 188 TYR B CD2 1 
ATOM   1864 C CE1 . TYR B 2 166 ? 140.706 142.156 150.465 1.00 44.80  ? 188 TYR B CE1 1 
ATOM   1865 C CE2 . TYR B 2 166 ? 141.427 142.257 152.742 1.00 44.80  ? 188 TYR B CE2 1 
ATOM   1866 C CZ  . TYR B 2 166 ? 141.693 142.389 151.397 1.00 44.80  ? 188 TYR B CZ  1 
ATOM   1867 O OH  . TYR B 2 166 ? 142.950 142.759 150.980 1.00 44.80  ? 188 TYR B OH  1 
ATOM   1868 N N   . TYR B 2 167 ? 134.729 141.223 152.463 1.00 42.30  ? 189 TYR B N   1 
ATOM   1869 C CA  . TYR B 2 167 ? 133.448 140.596 152.797 1.00 42.30  ? 189 TYR B CA  1 
ATOM   1870 C C   . TYR B 2 167 ? 132.380 141.620 153.174 1.00 42.30  ? 189 TYR B C   1 
ATOM   1871 O O   . TYR B 2 167 ? 131.468 141.320 153.947 1.00 42.30  ? 189 TYR B O   1 
ATOM   1872 C CB  . TYR B 2 167 ? 133.608 139.561 153.915 1.00 42.30  ? 189 TYR B CB  1 
ATOM   1873 C CG  . TYR B 2 167 ? 134.640 138.498 153.621 1.00 42.30  ? 189 TYR B CG  1 
ATOM   1874 C CD1 . TYR B 2 167 ? 134.346 137.433 152.782 1.00 42.30  ? 189 TYR B CD1 1 
ATOM   1875 C CD2 . TYR B 2 167 ? 135.905 138.556 154.187 1.00 42.30  ? 189 TYR B CD2 1 
ATOM   1876 C CE1 . TYR B 2 167 ? 135.285 136.458 152.510 1.00 42.30  ? 189 TYR B CE1 1 
ATOM   1877 C CE2 . TYR B 2 167 ? 136.851 137.585 153.921 1.00 42.30  ? 189 TYR B CE2 1 
ATOM   1878 C CZ  . TYR B 2 167 ? 136.534 136.538 153.082 1.00 42.30  ? 189 TYR B CZ  1 
ATOM   1879 O OH  . TYR B 2 167 ? 137.471 135.568 152.813 1.00 42.30  ? 189 TYR B OH  1 
ATOM   1880 N N   . VAL B 2 168 ? 132.474 142.834 152.634 1.00 40.47  ? 190 VAL B N   1 
ATOM   1881 C CA  . VAL B 2 168 ? 131.475 143.873 152.865 1.00 40.47  ? 190 VAL B CA  1 
ATOM   1882 C C   . VAL B 2 168 ? 131.263 144.632 151.562 1.00 40.47  ? 190 VAL B C   1 
ATOM   1883 O O   . VAL B 2 168 ? 132.218 145.168 150.990 1.00 40.47  ? 190 VAL B O   1 
ATOM   1884 C CB  . VAL B 2 168 ? 131.881 144.839 153.991 1.00 40.47  ? 190 VAL B CB  1 
ATOM   1885 C CG1 . VAL B 2 168 ? 131.557 144.238 155.349 1.00 40.47  ? 190 VAL B CG1 1 
ATOM   1886 C CG2 . VAL B 2 168 ? 133.361 145.170 153.901 1.00 40.47  ? 190 VAL B CG2 1 
ATOM   1887 N N   . ASN B 2 169 ? 130.019 144.676 151.091 1.00 40.99  ? 191 ASN B N   1 
ATOM   1888 C CA  . ASN B 2 169 ? 129.712 145.379 149.853 1.00 40.99  ? 191 ASN B CA  1 
ATOM   1889 C C   . ASN B 2 169 ? 129.919 146.879 150.023 1.00 40.99  ? 191 ASN B C   1 
ATOM   1890 O O   . ASN B 2 169 ? 129.514 147.470 151.027 1.00 40.99  ? 191 ASN B O   1 
ATOM   1891 C CB  . ASN B 2 169 ? 128.274 145.096 149.422 1.00 40.99  ? 191 ASN B CB  1 
ATOM   1892 C CG  . ASN B 2 169 ? 128.062 143.655 149.009 1.00 40.99  ? 191 ASN B CG  1 
ATOM   1893 O OD1 . ASN B 2 169 ? 127.258 142.939 149.605 1.00 40.99  ? 191 ASN B OD1 1 
ATOM   1894 N ND2 . ASN B 2 169 ? 128.780 143.222 147.982 1.00 40.99  ? 191 ASN B ND2 1 
ATOM   1895 N N   . ILE B 2 170 ? 130.555 147.493 149.029 1.00 40.10  ? 192 ILE B N   1 
ATOM   1896 C CA  . ILE B 2 170 ? 130.854 148.919 149.040 1.00 40.10  ? 192 ILE B CA  1 
ATOM   1897 C C   . ILE B 2 170 ? 130.382 149.521 147.723 1.00 40.10  ? 192 ILE B C   1 
ATOM   1898 O O   . ILE B 2 170 ? 130.463 148.876 146.672 1.00 40.10  ? 192 ILE B O   1 
ATOM   1899 C CB  . ILE B 2 170 ? 132.360 149.176 149.268 1.00 40.10  ? 192 ILE B CB  1 
ATOM   1900 C CG1 . ILE B 2 170 ? 132.653 150.673 149.375 1.00 40.10  ? 192 ILE B CG1 1 
ATOM   1901 C CG2 . ILE B 2 170 ? 133.192 148.539 148.167 1.00 40.10  ? 192 ILE B CG2 1 
ATOM   1902 C CD1 . ILE B 2 170 ? 134.108 150.983 149.641 1.00 40.10  ? 192 ILE B CD1 1 
ATOM   1903 N N   . GLU B 2 171 ? 129.870 150.748 147.784 1.00 46.91  ? 193 GLU B N   1 
ATOM   1904 C CA  . GLU B 2 171 ? 129.352 151.448 146.614 1.00 46.91  ? 193 GLU B CA  1 
ATOM   1905 C C   . GLU B 2 171 ? 130.145 152.731 146.412 1.00 46.91  ? 193 GLU B C   1 
ATOM   1906 O O   . GLU B 2 171 ? 130.251 153.549 147.331 1.00 46.91  ? 193 GLU B O   1 
ATOM   1907 C CB  . GLU B 2 171 ? 127.862 151.756 146.774 1.00 46.91  ? 193 GLU B CB  1 
ATOM   1908 C CG  . GLU B 2 171 ? 127.302 152.656 145.689 1.00 46.91  ? 193 GLU B CG  1 
ATOM   1909 C CD  . GLU B 2 171 ? 125.790 152.599 145.607 1.00 46.91  ? 193 GLU B CD  1 
ATOM   1910 O OE1 . GLU B 2 171 ? 125.226 151.498 145.774 1.00 46.91  ? 193 GLU B OE1 1 
ATOM   1911 O OE2 . GLU B 2 171 ? 125.167 153.655 145.372 1.00 46.91  ? 193 GLU B OE2 1 
ATOM   1912 N N   . VAL B 2 172 ? 130.695 152.906 145.211 1.00 46.32  ? 194 VAL B N   1 
ATOM   1913 C CA  . VAL B 2 172 ? 131.507 154.069 144.883 1.00 46.32  ? 194 VAL B CA  1 
ATOM   1914 C C   . VAL B 2 172 ? 130.964 154.724 143.621 1.00 46.32  ? 194 VAL B C   1 
ATOM   1915 O O   . VAL B 2 172 ? 130.325 154.077 142.785 1.00 46.32  ? 194 VAL B O   1 
ATOM   1916 C CB  . VAL B 2 172 ? 132.996 153.698 144.699 1.00 46.32  ? 194 VAL B CB  1 
ATOM   1917 C CG1 . VAL B 2 172 ? 133.569 153.140 145.990 1.00 46.32  ? 194 VAL B CG1 1 
ATOM   1918 C CG2 . VAL B 2 172 ? 133.158 152.700 143.568 1.00 46.32  ? 194 VAL B CG2 1 
ATOM   1919 N N   . TRP B 2 173 ? 131.223 156.024 143.491 1.00 50.26  ? 195 TRP B N   1 
ATOM   1920 C CA  . TRP B 2 173 ? 130.835 156.783 142.311 1.00 50.26  ? 195 TRP B CA  1 
ATOM   1921 C C   . TRP B 2 173 ? 131.627 158.082 142.293 1.00 50.26  ? 195 TRP B C   1 
ATOM   1922 O O   . TRP B 2 173 ? 132.072 158.565 143.336 1.00 50.26  ? 195 TRP B O   1 
ATOM   1923 C CB  . TRP B 2 173 ? 129.328 157.067 142.283 1.00 50.26  ? 195 TRP B CB  1 
ATOM   1924 C CG  . TRP B 2 173 ? 128.868 158.043 143.320 1.00 50.26  ? 195 TRP B CG  1 
ATOM   1925 C CD1 . TRP B 2 173 ? 128.732 159.392 143.172 1.00 50.26  ? 195 TRP B CD1 1 
ATOM   1926 C CD2 . TRP B 2 173 ? 128.475 157.746 144.665 1.00 50.26  ? 195 TRP B CD2 1 
ATOM   1927 N NE1 . TRP B 2 173 ? 128.282 159.954 144.341 1.00 50.26  ? 195 TRP B NE1 1 
ATOM   1928 C CE2 . TRP B 2 173 ? 128.116 158.964 145.274 1.00 50.26  ? 195 TRP B CE2 1 
ATOM   1929 C CE3 . TRP B 2 173 ? 128.393 156.569 145.414 1.00 50.26  ? 195 TRP B CE3 1 
ATOM   1930 C CZ2 . TRP B 2 173 ? 127.683 159.039 146.595 1.00 50.26  ? 195 TRP B CZ2 1 
ATOM   1931 C CZ3 . TRP B 2 173 ? 127.963 156.646 146.725 1.00 50.26  ? 195 TRP B CZ3 1 
ATOM   1932 C CH2 . TRP B 2 173 ? 127.613 157.871 147.302 1.00 50.26  ? 195 TRP B CH2 1 
ATOM   1933 N N   . VAL B 2 174 ? 131.796 158.640 141.097 1.00 55.19  ? 196 VAL B N   1 
ATOM   1934 C CA  . VAL B 2 174 ? 132.606 159.833 140.887 1.00 55.19  ? 196 VAL B CA  1 
ATOM   1935 C C   . VAL B 2 174 ? 131.705 160.969 140.425 1.00 55.19  ? 196 VAL B C   1 
ATOM   1936 O O   . VAL B 2 174 ? 130.774 160.758 139.639 1.00 55.19  ? 196 VAL B O   1 
ATOM   1937 C CB  . VAL B 2 174 ? 133.736 159.571 139.868 1.00 55.19  ? 196 VAL B CB  1 
ATOM   1938 C CG1 . VAL B 2 174 ? 133.170 159.019 138.568 1.00 55.19  ? 196 VAL B CG1 1 
ATOM   1939 C CG2 . VAL B 2 174 ? 134.539 160.835 139.614 1.00 55.19  ? 196 VAL B CG2 1 
ATOM   1940 N N   . GLU B 2 175 ? 131.976 162.174 140.925 1.00 59.63  ? 197 GLU B N   1 
ATOM   1941 C CA  . GLU B 2 175 ? 131.231 163.372 140.563 1.00 59.63  ? 197 GLU B CA  1 
ATOM   1942 C C   . GLU B 2 175 ? 132.162 164.355 139.871 1.00 59.63  ? 197 GLU B C   1 
ATOM   1943 O O   . GLU B 2 175 ? 133.256 164.637 140.370 1.00 59.63  ? 197 GLU B O   1 
ATOM   1944 C CB  . GLU B 2 175 ? 130.599 164.023 141.796 1.00 59.63  ? 197 GLU B CB  1 
ATOM   1945 C CG  . GLU B 2 175 ? 129.982 163.039 142.772 1.00 59.63  ? 197 GLU B CG  1 
ATOM   1946 C CD  . GLU B 2 175 ? 129.155 163.723 143.840 1.00 59.63  ? 197 GLU B CD  1 
ATOM   1947 O OE1 . GLU B 2 175 ? 128.258 164.515 143.482 1.00 59.63  ? 197 GLU B OE1 1 
ATOM   1948 O OE2 . GLU B 2 175 ? 129.400 163.470 145.038 1.00 59.63  ? 197 GLU B OE2 1 
ATOM   1949 N N   . ALA B 2 176 ? 131.726 164.875 138.727 1.00 64.35  ? 198 ALA B N   1 
ATOM   1950 C CA  . ALA B 2 176 ? 132.489 165.849 137.959 1.00 64.35  ? 198 ALA B CA  1 
ATOM   1951 C C   . ALA B 2 176 ? 131.854 167.223 138.129 1.00 64.35  ? 198 ALA B C   1 
ATOM   1952 O O   . ALA B 2 176 ? 130.663 167.398 137.848 1.00 64.35  ? 198 ALA B O   1 
ATOM   1953 C CB  . ALA B 2 176 ? 132.543 165.460 136.482 1.00 64.35  ? 198 ALA B CB  1 
ATOM   1954 N N   . GLU B 2 177 ? 132.644 168.191 138.585 1.00 70.72  ? 199 GLU B N   1 
ATOM   1955 C CA  . GLU B 2 177 ? 132.160 169.540 138.835 1.00 70.72  ? 199 GLU B CA  1 
ATOM   1956 C C   . GLU B 2 177 ? 133.117 170.558 138.234 1.00 70.72  ? 199 GLU B C   1 
ATOM   1957 O O   . GLU B 2 177 ? 134.338 170.431 138.367 1.00 70.72  ? 199 GLU B O   1 
ATOM   1958 C CB  . GLU B 2 177 ? 131.999 169.805 140.337 1.00 70.72  ? 199 GLU B CB  1 
ATOM   1959 C CG  . GLU B 2 177 ? 131.316 171.123 140.663 1.00 70.72  ? 199 GLU B CG  1 
ATOM   1960 C CD  . GLU B 2 177 ? 131.394 171.470 142.136 1.00 70.72  ? 199 GLU B CD  1 
ATOM   1961 O OE1 . GLU B 2 177 ? 132.520 171.559 142.668 1.00 70.72  ? 199 GLU B OE1 1 
ATOM   1962 O OE2 . GLU B 2 177 ? 130.329 171.656 142.762 1.00 70.72  ? 199 GLU B OE2 1 
ATOM   1963 N N   . ASN B 2 178 ? 132.553 171.567 137.576 1.00 70.57  ? 200 ASN B N   1 
ATOM   1964 C CA  . ASN B 2 178 ? 133.322 172.668 137.013 1.00 70.57  ? 200 ASN B CA  1 
ATOM   1965 C C   . ASN B 2 178 ? 132.527 173.952 137.227 1.00 70.57  ? 200 ASN B C   1 
ATOM   1966 O O   . ASN B 2 178 ? 131.563 173.988 137.997 1.00 70.57  ? 200 ASN B O   1 
ATOM   1967 C CB  . ASN B 2 178 ? 133.646 172.412 135.534 1.00 70.57  ? 200 ASN B CB  1 
ATOM   1968 C CG  . ASN B 2 178 ? 132.424 172.505 134.642 1.00 70.57  ? 200 ASN B CG  1 
ATOM   1969 O OD1 . ASN B 2 178 ? 131.306 172.214 135.066 1.00 70.57  ? 200 ASN B OD1 1 
ATOM   1970 N ND2 . ASN B 2 178 ? 132.634 172.910 133.395 1.00 70.57  ? 200 ASN B ND2 1 
ATOM   1971 N N   . ALA B 2 179 ? 132.933 175.017 136.541 1.00 66.79  ? 201 ALA B N   1 
ATOM   1972 C CA  . ALA B 2 179 ? 132.290 176.316 136.680 1.00 66.79  ? 201 ALA B CA  1 
ATOM   1973 C C   . ALA B 2 179 ? 130.994 176.435 135.884 1.00 66.79  ? 201 ALA B C   1 
ATOM   1974 O O   . ALA B 2 179 ? 130.443 177.538 135.796 1.00 66.79  ? 201 ALA B O   1 
ATOM   1975 C CB  . ALA B 2 179 ? 133.256 177.427 136.260 1.00 66.79  ? 201 ALA B CB  1 
ATOM   1976 N N   . LEU B 2 180 ? 130.491 175.341 135.309 1.00 66.99  ? 202 LEU B N   1 
ATOM   1977 C CA  . LEU B 2 180 ? 129.273 175.386 134.512 1.00 66.99  ? 202 LEU B CA  1 
ATOM   1978 C C   . LEU B 2 180 ? 128.278 174.277 134.819 1.00 66.99  ? 202 LEU B C   1 
ATOM   1979 O O   . LEU B 2 180 ? 127.171 174.306 134.270 1.00 66.99  ? 202 LEU B O   1 
ATOM   1980 C CB  . LEU B 2 180 ? 129.608 175.343 133.013 1.00 66.99  ? 202 LEU B CB  1 
ATOM   1981 C CG  . LEU B 2 180 ? 129.929 176.687 132.358 1.00 66.99  ? 202 LEU B CG  1 
ATOM   1982 C CD1 . LEU B 2 180 ? 130.272 176.503 130.890 1.00 66.99  ? 202 LEU B CD1 1 
ATOM   1983 C CD2 . LEU B 2 180 ? 128.762 177.647 132.521 1.00 66.99  ? 202 LEU B CD2 1 
ATOM   1984 N N   . GLY B 2 181 ? 128.623 173.308 135.663 1.00 67.70  ? 203 GLY B N   1 
ATOM   1985 C CA  . GLY B 2 181 ? 127.696 172.243 135.993 1.00 67.70  ? 203 GLY B CA  1 
ATOM   1986 C C   . GLY B 2 181 ? 128.308 171.139 136.830 1.00 67.70  ? 203 GLY B C   1 
ATOM   1987 O O   . GLY B 2 181 ? 129.534 171.012 136.904 1.00 67.70  ? 203 GLY B O   1 
ATOM   1988 N N   . LYS B 2 182 ? 127.462 170.333 137.466 1.00 63.99  ? 204 LYS B N   1 
ATOM   1989 C CA  . LYS B 2 182 ? 127.909 169.219 138.294 1.00 63.99  ? 204 LYS B CA  1 
ATOM   1990 C C   . LYS B 2 182 ? 127.122 167.978 137.903 1.00 63.99  ? 204 LYS B C   1 
ATOM   1991 O O   . LYS B 2 182 ? 125.888 167.981 137.961 1.00 63.99  ? 204 LYS B O   1 
ATOM   1992 C CB  . LYS B 2 182 ? 127.727 169.527 139.783 1.00 63.99  ? 204 LYS B CB  1 
ATOM   1993 C CG  . LYS B 2 182 ? 128.243 168.437 140.707 1.00 63.99  ? 204 LYS B CG  1 
ATOM   1994 C CD  . LYS B 2 182 ? 128.090 168.833 142.166 1.00 63.99  ? 204 LYS B CD  1 
ATOM   1995 C CE  . LYS B 2 182 ? 128.714 167.796 143.085 1.00 63.99  ? 204 LYS B CE  1 
ATOM   1996 N NZ  . LYS B 2 182 ? 128.550 168.158 144.520 1.00 63.99  ? 204 LYS B NZ  1 
ATOM   1997 N N   . VAL B 2 183 ? 127.832 166.925 137.507 1.00 59.55  ? 205 VAL B N   1 
ATOM   1998 C CA  . VAL B 2 183 ? 127.214 165.672 137.092 1.00 59.55  ? 205 VAL B CA  1 
ATOM   1999 C C   . VAL B 2 183 ? 128.007 164.519 137.692 1.00 59.55  ? 205 VAL B C   1 
ATOM   2000 O O   . VAL B 2 183 ? 129.242 164.547 137.721 1.00 59.55  ? 205 VAL B O   1 
ATOM   2001 C CB  . VAL B 2 183 ? 127.136 165.563 135.553 1.00 59.55  ? 205 VAL B CB  1 
ATOM   2002 C CG1 . VAL B 2 183 ? 128.513 165.731 134.928 1.00 59.55  ? 205 VAL B CG1 1 
ATOM   2003 C CG2 . VAL B 2 183 ? 126.506 164.244 135.136 1.00 59.55  ? 205 VAL B CG2 1 
ATOM   2004 N N   . SER B 2 184 ? 127.294 163.511 138.187 1.00 57.18  ? 206 SER B N   1 
ATOM   2005 C CA  . SER B 2 184 ? 127.897 162.342 138.808 1.00 57.18  ? 206 SER B CA  1 
ATOM   2006 C C   . SER B 2 184 ? 127.594 161.100 137.982 1.00 57.18  ? 206 SER B C   1 
ATOM   2007 O O   . SER B 2 184 ? 126.502 160.968 137.420 1.00 57.18  ? 206 SER B O   1 
ATOM   2008 C CB  . SER B 2 184 ? 127.385 162.156 140.238 1.00 57.18  ? 206 SER B CB  1 
ATOM   2009 O OG  . SER B 2 184 ? 125.982 162.338 140.303 1.00 57.18  ? 206 SER B OG  1 
ATOM   2010 N N   . SER B 2 185 ? 128.563 160.192 137.914 1.00 56.03  ? 207 SER B N   1 
ATOM   2011 C CA  . SER B 2 185 ? 128.423 158.979 137.124 1.00 56.03  ? 207 SER B CA  1 
ATOM   2012 C C   . SER B 2 185 ? 127.548 157.963 137.855 1.00 56.03  ? 207 SER B C   1 
ATOM   2013 O O   . SER B 2 185 ? 127.021 158.217 138.941 1.00 56.03  ? 207 SER B O   1 
ATOM   2014 C CB  . SER B 2 185 ? 129.796 158.389 136.814 1.00 56.03  ? 207 SER B CB  1 
ATOM   2015 O OG  . SER B 2 185 ? 130.213 157.510 137.843 1.00 56.03  ? 207 SER B OG  1 
ATOM   2016 N N   . GLU B 2 186 ? 127.394 156.791 137.247 1.00 53.82  ? 208 GLU B N   1 
ATOM   2017 C CA  . GLU B 2 186 ? 126.627 155.717 137.856 1.00 53.82  ? 208 GLU B CA  1 
ATOM   2018 C C   . GLU B 2 186 ? 127.452 155.012 138.925 1.00 53.82  ? 208 GLU B C   1 
ATOM   2019 O O   . GLU B 2 186 ? 128.680 154.929 138.840 1.00 53.82  ? 208 GLU B O   1 
ATOM   2020 C CB  . GLU B 2 186 ? 126.173 154.710 136.798 1.00 53.82  ? 208 GLU B CB  1 
ATOM   2021 C CG  . GLU B 2 186 ? 125.333 155.308 135.681 1.00 53.82  ? 208 GLU B CG  1 
ATOM   2022 C CD  . GLU B 2 186 ? 123.881 155.500 136.074 1.00 53.82  ? 208 GLU B CD  1 
ATOM   2023 O OE1 . GLU B 2 186 ? 123.607 156.297 136.995 1.00 53.82  ? 208 GLU B OE1 1 
ATOM   2024 O OE2 . GLU B 2 186 ? 123.010 154.851 135.458 1.00 53.82  ? 208 GLU B OE2 1 
ATOM   2025 N N   . SER B 2 187 ? 126.762 154.501 139.939 1.00 48.73  ? 209 SER B N   1 
ATOM   2026 C CA  . SER B 2 187 ? 127.411 153.827 141.051 1.00 48.73  ? 209 SER B CA  1 
ATOM   2027 C C   . SER B 2 187 ? 127.473 152.324 140.809 1.00 48.73  ? 209 SER B C   1 
ATOM   2028 O O   . SER B 2 187 ? 126.579 151.735 140.196 1.00 48.73  ? 209 SER B O   1 
ATOM   2029 C CB  . SER B 2 187 ? 126.673 154.112 142.358 1.00 48.73  ? 209 SER B CB  1 
ATOM   2030 O OG  . SER B 2 187 ? 125.277 153.922 142.204 1.00 48.73  ? 209 SER B OG  1 
ATOM   2031 N N   . ILE B 2 188 ? 128.544 151.707 141.302 1.00 46.24  ? 210 ILE B N   1 
ATOM   2032 C CA  . ILE B 2 188 ? 128.754 150.270 141.189 1.00 46.24  ? 210 ILE B CA  1 
ATOM   2033 C C   . ILE B 2 188 ? 128.823 149.678 142.589 1.00 46.24  ? 210 ILE B C   1 
ATOM   2034 O O   . ILE B 2 188 ? 129.382 150.289 143.506 1.00 46.24  ? 210 ILE B O   1 
ATOM   2035 C CB  . ILE B 2 188 ? 130.033 149.936 140.392 1.00 46.24  ? 210 ILE B CB  1 
ATOM   2036 C CG1 . ILE B 2 188 ? 131.242 150.659 140.986 1.00 46.24  ? 210 ILE B CG1 1 
ATOM   2037 C CG2 . ILE B 2 188 ? 129.857 150.302 138.928 1.00 46.24  ? 210 ILE B CG2 1 
ATOM   2038 C CD1 . ILE B 2 188 ? 132.545 150.331 140.297 1.00 46.24  ? 210 ILE B CD1 1 
ATOM   2039 N N   . ASN B 2 189 ? 128.247 148.489 142.751 1.00 44.12  ? 211 ASN B N   1 
ATOM   2040 C CA  . ASN B 2 189 ? 128.225 147.781 144.027 1.00 44.12  ? 211 ASN B CA  1 
ATOM   2041 C C   . ASN B 2 189 ? 128.995 146.479 143.857 1.00 44.12  ? 211 ASN B C   1 
ATOM   2042 O O   . ASN B 2 189 ? 128.577 145.601 143.094 1.00 44.12  ? 211 ASN B O   1 
ATOM   2043 C CB  . ASN B 2 189 ? 126.790 147.520 144.483 1.00 44.12  ? 211 ASN B CB  1 
ATOM   2044 C CG  . ASN B 2 189 ? 126.692 147.243 145.967 1.00 44.12  ? 211 ASN B CG  1 
ATOM   2045 O OD1 . ASN B 2 189 ? 127.681 146.900 146.613 1.00 44.12  ? 211 ASN B OD1 1 
ATOM   2046 N ND2 . ASN B 2 189 ? 125.493 147.391 146.517 1.00 44.12  ? 211 ASN B ND2 1 
ATOM   2047 N N   . PHE B 2 190 ? 130.116 146.353 144.564 1.00 40.04  ? 212 PHE B N   1 
ATOM   2048 C CA  . PHE B 2 190 ? 130.993 145.202 144.421 1.00 40.04  ? 212 PHE B CA  1 
ATOM   2049 C C   . PHE B 2 190 ? 131.584 144.837 145.776 1.00 40.04  ? 212 PHE B C   1 
ATOM   2050 O O   . PHE B 2 190 ? 131.358 145.511 146.783 1.00 40.04  ? 212 PHE B O   1 
ATOM   2051 C CB  . PHE B 2 190 ? 132.110 145.474 143.406 1.00 40.04  ? 212 PHE B CB  1 
ATOM   2052 C CG  . PHE B 2 190 ? 133.098 146.511 143.856 1.00 40.04  ? 212 PHE B CG  1 
ATOM   2053 C CD1 . PHE B 2 190 ? 132.801 147.859 143.757 1.00 40.04  ? 212 PHE B CD1 1 
ATOM   2054 C CD2 . PHE B 2 190 ? 134.324 146.138 144.377 1.00 40.04  ? 212 PHE B CD2 1 
ATOM   2055 C CE1 . PHE B 2 190 ? 133.707 148.813 144.171 1.00 40.04  ? 212 PHE B CE1 1 
ATOM   2056 C CE2 . PHE B 2 190 ? 135.234 147.088 144.792 1.00 40.04  ? 212 PHE B CE2 1 
ATOM   2057 C CZ  . PHE B 2 190 ? 134.924 148.427 144.688 1.00 40.04  ? 212 PHE B CZ  1 
ATOM   2058 N N   . ASP B 2 191 ? 132.351 143.747 145.786 1.00 41.07  ? 213 ASP B N   1 
ATOM   2059 C CA  . ASP B 2 191 ? 133.029 143.247 146.970 1.00 41.07  ? 213 ASP B CA  1 
ATOM   2060 C C   . ASP B 2 191 ? 134.529 143.438 146.820 1.00 41.07  ? 213 ASP B C   1 
ATOM   2061 O O   . ASP B 2 191 ? 135.096 143.029 145.798 1.00 41.07  ? 213 ASP B O   1 
ATOM   2062 C CB  . ASP B 2 191 ? 132.707 141.762 147.180 1.00 41.07  ? 213 ASP B CB  1 
ATOM   2063 C CG  . ASP B 2 191 ? 132.987 141.293 148.595 1.00 41.07  ? 213 ASP B CG  1 
ATOM   2064 O OD1 . ASP B 2 191 ? 134.027 141.680 149.166 1.00 41.07  ? 213 ASP B OD1 1 
ATOM   2065 O OD2 . ASP B 2 191 ? 132.165 140.527 149.137 1.00 41.07  ? 213 ASP B OD2 1 
ATOM   2066 N N   . PRO B 2 192 ? 135.203 144.053 147.795 1.00 39.82  ? 214 PRO B N   1 
ATOM   2067 C CA  . PRO B 2 192 ? 136.657 144.250 147.672 1.00 39.82  ? 214 PRO B CA  1 
ATOM   2068 C C   . PRO B 2 192 ? 137.451 142.959 147.575 1.00 39.82  ? 214 PRO B C   1 
ATOM   2069 O O   . PRO B 2 192 ? 138.618 143.001 147.168 1.00 39.82  ? 214 PRO B O   1 
ATOM   2070 C CB  . PRO B 2 192 ? 137.014 145.029 148.944 1.00 39.82  ? 214 PRO B CB  1 
ATOM   2071 C CG  . PRO B 2 192 ? 135.747 145.702 149.341 1.00 39.82  ? 214 PRO B CG  1 
ATOM   2072 C CD  . PRO B 2 192 ? 134.649 144.754 148.965 1.00 39.82  ? 214 PRO B CD  1 
ATOM   2073 N N   . VAL B 2 193 ? 136.867 141.816 147.939 1.00 41.97  ? 215 VAL B N   1 
ATOM   2074 C CA  . VAL B 2 193 ? 137.589 140.553 147.837 1.00 41.97  ? 215 VAL B CA  1 
ATOM   2075 C C   . VAL B 2 193 ? 137.543 139.981 146.424 1.00 41.97  ? 215 VAL B C   1 
ATOM   2076 O O   . VAL B 2 193 ? 138.342 139.095 146.096 1.00 41.97  ? 215 VAL B O   1 
ATOM   2077 C CB  . VAL B 2 193 ? 137.038 139.535 148.851 1.00 41.97  ? 215 VAL B CB  1 
ATOM   2078 C CG1 . VAL B 2 193 ? 135.761 138.893 148.332 1.00 41.97  ? 215 VAL B CG1 1 
ATOM   2079 C CG2 . VAL B 2 193 ? 138.086 138.482 149.181 1.00 41.97  ? 215 VAL B CG2 1 
ATOM   2080 N N   . ASP B 2 194 ? 136.638 140.465 145.576 1.00 44.64  ? 216 ASP B N   1 
ATOM   2081 C CA  . ASP B 2 194 ? 136.529 139.996 144.202 1.00 44.64  ? 216 ASP B CA  1 
ATOM   2082 C C   . ASP B 2 194 ? 137.310 140.852 143.214 1.00 44.64  ? 216 ASP B C   1 
ATOM   2083 O O   . ASP B 2 194 ? 137.235 140.602 142.007 1.00 44.64  ? 216 ASP B O   1 
ATOM   2084 C CB  . ASP B 2 194 ? 135.057 139.941 143.779 1.00 44.64  ? 216 ASP B CB  1 
ATOM   2085 C CG  . ASP B 2 194 ? 134.282 138.865 144.510 1.00 44.64  ? 216 ASP B CG  1 
ATOM   2086 O OD1 . ASP B 2 194 ? 134.907 138.091 145.264 1.00 44.64  ? 216 ASP B OD1 1 
ATOM   2087 O OD2 . ASP B 2 194 ? 133.049 138.792 144.331 1.00 44.64  ? 216 ASP B OD2 1 
ATOM   2088 N N   . LYS B 2 195 ? 138.054 141.852 143.689 1.00 43.03  ? 217 LYS B N   1 
ATOM   2089 C CA  . LYS B 2 195 ? 138.848 142.719 142.827 1.00 43.03  ? 217 LYS B CA  1 
ATOM   2090 C C   . LYS B 2 195 ? 140.323 142.708 143.211 1.00 43.03  ? 217 LYS B C   1 
ATOM   2091 O O   . LYS B 2 195 ? 141.050 143.655 142.897 1.00 43.03  ? 217 LYS B O   1 
ATOM   2092 C CB  . LYS B 2 195 ? 138.307 144.150 142.858 1.00 43.03  ? 217 LYS B CB  1 
ATOM   2093 C CG  . LYS B 2 195 ? 136.823 144.269 142.559 1.00 43.03  ? 217 LYS B CG  1 
ATOM   2094 C CD  . LYS B 2 195 ? 136.502 143.808 141.149 1.00 43.03  ? 217 LYS B CD  1 
ATOM   2095 C CE  . LYS B 2 195 ? 135.025 143.988 140.836 1.00 43.03  ? 217 LYS B CE  1 
ATOM   2096 N NZ  . LYS B 2 195 ? 134.696 143.561 139.449 1.00 43.03  ? 217 LYS B NZ  1 
ATOM   2097 N N   . VAL B 2 196 ? 140.779 141.657 143.884 1.00 46.32  ? 218 VAL B N   1 
ATOM   2098 C CA  . VAL B 2 196 ? 142.146 141.606 144.388 1.00 46.32  ? 218 VAL B CA  1 
ATOM   2099 C C   . VAL B 2 196 ? 143.072 141.086 143.294 1.00 46.32  ? 218 VAL B C   1 
ATOM   2100 O O   . VAL B 2 196 ? 142.712 140.180 142.532 1.00 46.32  ? 218 VAL B O   1 
ATOM   2101 C CB  . VAL B 2 196 ? 142.225 140.741 145.658 1.00 46.32  ? 218 VAL B CB  1 
ATOM   2102 C CG1 . VAL B 2 196 ? 141.901 139.289 145.350 1.00 46.32  ? 218 VAL B CG1 1 
ATOM   2103 C CG2 . VAL B 2 196 ? 143.596 140.865 146.307 1.00 46.32  ? 218 VAL B CG2 1 
ATOM   2104 N N   . LYS B 2 197 ? 144.256 141.687 143.192 1.00 51.13  ? 219 LYS B N   1 
ATOM   2105 C CA  . LYS B 2 197 ? 145.296 141.238 142.272 1.00 51.13  ? 219 LYS B CA  1 
ATOM   2106 C C   . LYS B 2 197 ? 146.464 140.691 143.081 1.00 51.13  ? 219 LYS B C   1 
ATOM   2107 O O   . LYS B 2 197 ? 147.253 141.472 143.637 1.00 51.13  ? 219 LYS B O   1 
ATOM   2108 C CB  . LYS B 2 197 ? 145.757 142.382 141.366 1.00 51.13  ? 219 LYS B CB  1 
ATOM   2109 C CG  . LYS B 2 197 ? 146.809 141.977 140.348 1.00 51.13  ? 219 LYS B CG  1 
ATOM   2110 C CD  . LYS B 2 197 ? 147.162 143.129 139.423 1.00 51.13  ? 219 LYS B CD  1 
ATOM   2111 C CE  . LYS B 2 197 ? 148.198 142.707 138.394 1.00 51.13  ? 219 LYS B CE  1 
ATOM   2112 N NZ  . LYS B 2 197 ? 148.527 143.805 137.443 1.00 51.13  ? 219 LYS B NZ  1 
ATOM   2113 N N   . PRO B 2 198 ? 146.617 139.375 143.189 1.00 51.50  ? 220 PRO B N   1 
ATOM   2114 C CA  . PRO B 2 198 ? 147.670 138.820 144.044 1.00 51.50  ? 220 PRO B CA  1 
ATOM   2115 C C   . PRO B 2 198 ? 149.058 139.077 143.477 1.00 51.50  ? 220 PRO B C   1 
ATOM   2116 O O   . PRO B 2 198 ? 149.236 139.416 142.306 1.00 51.50  ? 220 PRO B O   1 
ATOM   2117 C CB  . PRO B 2 198 ? 147.357 137.318 144.072 1.00 51.50  ? 220 PRO B CB  1 
ATOM   2118 C CG  . PRO B 2 198 ? 145.952 137.195 143.559 1.00 51.50  ? 220 PRO B CG  1 
ATOM   2119 C CD  . PRO B 2 198 ? 145.773 138.323 142.602 1.00 51.50  ? 220 PRO B CD  1 
ATOM   2120 N N   . THR B 2 199 ? 150.052 138.915 144.343 1.00 56.71  ? 221 THR B N   1 
ATOM   2121 C CA  . THR B 2 199 ? 151.434 139.008 143.905 1.00 56.71  ? 221 THR B CA  1 
ATOM   2122 C C   . THR B 2 199 ? 151.897 137.665 143.341 1.00 56.71  ? 221 THR B C   1 
ATOM   2123 O O   . THR B 2 199 ? 151.427 136.608 143.774 1.00 56.71  ? 221 THR B O   1 
ATOM   2124 C CB  . THR B 2 199 ? 152.337 139.426 145.062 1.00 56.71  ? 221 THR B CB  1 
ATOM   2125 O OG1 . THR B 2 199 ? 152.552 138.309 145.933 1.00 56.71  ? 221 THR B OG1 1 
ATOM   2126 C CG2 . THR B 2 199 ? 151.708 140.569 145.847 1.00 56.71  ? 221 THR B CG2 1 
ATOM   2127 N N   . PRO B 2 200 ? 152.807 137.678 142.371 1.00 60.09  ? 222 PRO B N   1 
ATOM   2128 C CA  . PRO B 2 200 ? 153.260 136.425 141.758 1.00 60.09  ? 222 PRO B CA  1 
ATOM   2129 C C   . PRO B 2 200 ? 153.981 135.553 142.768 1.00 60.09  ? 222 PRO B C   1 
ATOM   2130 O O   . PRO B 2 200 ? 154.721 136.060 143.624 1.00 60.09  ? 222 PRO B O   1 
ATOM   2131 C CB  . PRO B 2 200 ? 154.213 136.898 140.649 1.00 60.09  ? 222 PRO B CB  1 
ATOM   2132 C CG  . PRO B 2 200 ? 154.655 138.253 141.085 1.00 60.09  ? 222 PRO B CG  1 
ATOM   2133 C CD  . PRO B 2 200 ? 153.471 138.851 141.778 1.00 60.09  ? 222 PRO B CD  1 
ATOM   2134 N N   . PRO B 2 201 ? 153.780 134.237 142.709 1.00 64.15  ? 223 PRO B N   1 
ATOM   2135 C CA  . PRO B 2 201 ? 154.462 133.345 143.652 1.00 64.15  ? 223 PRO B CA  1 
ATOM   2136 C C   . PRO B 2 201 ? 155.972 133.406 143.484 1.00 64.15  ? 223 PRO B C   1 
ATOM   2137 O O   . PRO B 2 201 ? 156.491 133.621 142.387 1.00 64.15  ? 223 PRO B O   1 
ATOM   2138 C CB  . PRO B 2 201 ? 153.915 131.958 143.291 1.00 64.15  ? 223 PRO B CB  1 
ATOM   2139 C CG  . PRO B 2 201 ? 152.631 132.228 142.571 1.00 64.15  ? 223 PRO B CG  1 
ATOM   2140 C CD  . PRO B 2 201 ? 152.852 133.508 141.830 1.00 64.15  ? 223 PRO B CD  1 
ATOM   2141 N N   . TYR B 2 202 ? 156.676 133.214 144.591 1.00 67.85  ? 224 TYR B N   1 
ATOM   2142 C CA  . TYR B 2 202 ? 158.129 133.286 144.629 1.00 67.85  ? 224 TYR B CA  1 
ATOM   2143 C C   . TYR B 2 202 ? 158.699 131.968 145.142 1.00 67.85  ? 224 TYR B C   1 
ATOM   2144 O O   . TYR B 2 202 ? 157.966 131.057 145.535 1.00 67.85  ? 224 TYR B O   1 
ATOM   2145 C CB  . TYR B 2 202 ? 158.593 134.462 145.494 1.00 67.85  ? 224 TYR B CB  1 
ATOM   2146 C CG  . TYR B 2 202 ? 157.889 134.568 146.828 1.00 67.85  ? 224 TYR B CG  1 
ATOM   2147 C CD1 . TYR B 2 202 ? 156.740 135.335 146.970 1.00 67.85  ? 224 TYR B CD1 1 
ATOM   2148 C CD2 . TYR B 2 202 ? 158.378 133.909 147.947 1.00 67.85  ? 224 TYR B CD2 1 
ATOM   2149 C CE1 . TYR B 2 202 ? 156.095 135.437 148.187 1.00 67.85  ? 224 TYR B CE1 1 
ATOM   2150 C CE2 . TYR B 2 202 ? 157.741 134.006 149.168 1.00 67.85  ? 224 TYR B CE2 1 
ATOM   2151 C CZ  . TYR B 2 202 ? 156.600 134.770 149.282 1.00 67.85  ? 224 TYR B CZ  1 
ATOM   2152 O OH  . TYR B 2 202 ? 155.962 134.868 150.497 1.00 67.85  ? 224 TYR B OH  1 
ATOM   2153 N N   . ASN B 2 203 ? 160.031 131.882 145.130 1.00 73.49  ? 225 ASN B N   1 
ATOM   2154 C CA  . ASN B 2 203 ? 160.759 130.684 145.552 1.00 73.49  ? 225 ASN B CA  1 
ATOM   2155 C C   . ASN B 2 203 ? 160.333 129.462 144.742 1.00 73.49  ? 225 ASN B C   1 
ATOM   2156 O O   . ASN B 2 203 ? 160.051 128.394 145.290 1.00 73.49  ? 225 ASN B O   1 
ATOM   2157 C CB  . ASN B 2 203 ? 160.598 130.436 147.054 1.00 73.49  ? 225 ASN B CB  1 
ATOM   2158 C CG  . ASN B 2 203 ? 161.374 131.432 147.888 1.00 73.49  ? 225 ASN B CG  1 
ATOM   2159 O OD1 . ASN B 2 203 ? 161.407 132.623 147.577 1.00 73.49  ? 225 ASN B OD1 1 
ATOM   2160 N ND2 . ASN B 2 203 ? 162.011 130.953 148.949 1.00 73.49  ? 225 ASN B ND2 1 
ATOM   2161 N N   . LEU B 2 204 ? 160.288 129.623 143.423 1.00 67.87  ? 226 LEU B N   1 
ATOM   2162 C CA  . LEU B 2 204 ? 159.935 128.526 142.532 1.00 67.87  ? 226 LEU B CA  1 
ATOM   2163 C C   . LEU B 2 204 ? 161.131 127.595 142.368 1.00 67.87  ? 226 LEU B C   1 
ATOM   2164 O O   . LEU B 2 204 ? 162.210 128.028 141.950 1.00 67.87  ? 226 LEU B O   1 
ATOM   2165 C CB  . LEU B 2 204 ? 159.485 129.079 141.181 1.00 67.87  ? 226 LEU B CB  1 
ATOM   2166 C CG  . LEU B 2 204 ? 158.491 128.277 140.336 1.00 67.87  ? 226 LEU B CG  1 
ATOM   2167 C CD1 . LEU B 2 204 ? 157.962 129.138 139.203 1.00 67.87  ? 226 LEU B CD1 1 
ATOM   2168 C CD2 . LEU B 2 204 ? 159.121 127.011 139.782 1.00 67.87  ? 226 LEU B CD2 1 
ATOM   2169 N N   . SER B 2 205 ? 160.942 126.319 142.694 1.00 63.33  ? 227 SER B N   1 
ATOM   2170 C CA  . SER B 2 205 ? 161.998 125.320 142.610 1.00 63.33  ? 227 SER B CA  1 
ATOM   2171 C C   . SER B 2 205 ? 161.520 124.126 141.797 1.00 63.33  ? 227 SER B C   1 
ATOM   2172 O O   . SER B 2 205 ? 160.387 123.663 141.962 1.00 63.33  ? 227 SER B O   1 
ATOM   2173 C CB  . SER B 2 205 ? 162.433 124.859 144.004 1.00 63.33  ? 227 SER B CB  1 
ATOM   2174 O OG  . SER B 2 205 ? 161.630 123.783 144.456 1.00 63.33  ? 227 SER B OG  1 
ATOM   2175 N N   . VAL B 2 206 ? 162.389 123.630 140.921 1.00 61.49  ? 228 VAL B N   1 
ATOM   2176 C CA  . VAL B 2 206 ? 162.099 122.478 140.075 1.00 61.49  ? 228 VAL B CA  1 
ATOM   2177 C C   . VAL B 2 206 ? 162.993 121.329 140.521 1.00 61.49  ? 228 VAL B C   1 
ATOM   2178 O O   . VAL B 2 206 ? 164.224 121.445 140.497 1.00 61.49  ? 228 VAL B O   1 
ATOM   2179 C CB  . VAL B 2 206 ? 162.312 122.797 138.588 1.00 61.49  ? 228 VAL B CB  1 
ATOM   2180 C CG1 . VAL B 2 206 ? 162.100 121.550 137.744 1.00 61.49  ? 228 VAL B CG1 1 
ATOM   2181 C CG2 . VAL B 2 206 ? 161.377 123.912 138.146 1.00 61.49  ? 228 VAL B CG2 1 
ATOM   2182 N N   . THR B 2 207 ? 162.376 120.222 140.925 1.00 64.63  ? 229 THR B N   1 
ATOM   2183 C CA  . THR B 2 207 ? 163.091 119.046 141.399 1.00 64.63  ? 229 THR B CA  1 
ATOM   2184 C C   . THR B 2 207 ? 162.798 117.864 140.487 1.00 64.63  ? 229 THR B C   1 
ATOM   2185 O O   . THR B 2 207 ? 161.658 117.668 140.055 1.00 64.63  ? 229 THR B O   1 
ATOM   2186 C CB  . THR B 2 207 ? 162.700 118.695 142.838 1.00 64.63  ? 229 THR B CB  1 
ATOM   2187 O OG1 . THR B 2 207 ? 161.463 117.971 142.835 1.00 64.63  ? 229 THR B OG1 1 
ATOM   2188 C CG2 . THR B 2 207 ? 162.538 119.957 143.671 1.00 64.63  ? 229 THR B CG2 1 
ATOM   2189 N N   . ASN B 2 208 ? 163.831 117.076 140.201 1.00 70.29  ? 230 ASN B N   1 
ATOM   2190 C CA  . ASN B 2 208 ? 163.698 115.908 139.347 1.00 70.29  ? 230 ASN B CA  1 
ATOM   2191 C C   . ASN B 2 208 ? 163.369 114.675 140.186 1.00 70.29  ? 230 ASN B C   1 
ATOM   2192 O O   . ASN B 2 208 ? 163.176 114.750 141.402 1.00 70.29  ? 230 ASN B O   1 
ATOM   2193 C CB  . ASN B 2 208 ? 164.974 115.698 138.534 1.00 70.29  ? 230 ASN B CB  1 
ATOM   2194 C CG  . ASN B 2 208 ? 166.228 115.810 139.377 1.00 70.29  ? 230 ASN B CG  1 
ATOM   2195 O OD1 . ASN B 2 208 ? 166.166 115.822 140.606 1.00 70.29  ? 230 ASN B OD1 1 
ATOM   2196 N ND2 . ASN B 2 208 ? 167.378 115.889 138.719 1.00 70.29  ? 230 ASN B ND2 1 
ATOM   2197 N N   . SER B 2 209 ? 163.301 113.520 139.528 1.00 75.96  ? 231 SER B N   1 
ATOM   2198 C CA  . SER B 2 209 ? 163.021 112.254 140.192 1.00 75.96  ? 231 SER B CA  1 
ATOM   2199 C C   . SER B 2 209 ? 163.933 111.177 139.626 1.00 75.96  ? 231 SER B C   1 
ATOM   2200 O O   . SER B 2 209 ? 164.034 111.023 138.405 1.00 75.96  ? 231 SER B O   1 
ATOM   2201 C CB  . SER B 2 209 ? 161.554 111.848 140.022 1.00 75.96  ? 231 SER B CB  1 
ATOM   2202 O OG  . SER B 2 209 ? 161.388 110.458 140.238 1.00 75.96  ? 231 SER B OG  1 
ATOM   2203 N N   . GLU B 2 210 ? 164.585 110.428 140.517 1.00 79.84  ? 232 GLU B N   1 
ATOM   2204 C CA  . GLU B 2 210 ? 165.530 109.408 140.076 1.00 79.84  ? 232 GLU B CA  1 
ATOM   2205 C C   . GLU B 2 210 ? 164.818 108.202 139.475 1.00 79.84  ? 232 GLU B C   1 
ATOM   2206 O O   . GLU B 2 210 ? 165.341 107.576 138.547 1.00 79.84  ? 232 GLU B O   1 
ATOM   2207 C CB  . GLU B 2 210 ? 166.427 109.000 141.252 1.00 79.84  ? 232 GLU B CB  1 
ATOM   2208 C CG  . GLU B 2 210 ? 167.354 107.806 141.018 1.00 79.84  ? 232 GLU B CG  1 
ATOM   2209 C CD  . GLU B 2 210 ? 166.677 106.465 141.239 1.00 79.84  ? 232 GLU B CD  1 
ATOM   2210 O OE1 . GLU B 2 210 ? 167.274 105.429 140.877 1.00 79.84  ? 232 GLU B OE1 1 
ATOM   2211 O OE2 . GLU B 2 210 ? 165.555 106.448 141.786 1.00 79.84  ? 232 GLU B OE2 1 
ATOM   2212 N N   . GLU B 2 211 ? 163.628 107.866 139.976 1.00 80.24  ? 233 GLU B N   1 
ATOM   2213 C CA  . GLU B 2 211 ? 162.925 106.687 139.482 1.00 80.24  ? 233 GLU B CA  1 
ATOM   2214 C C   . GLU B 2 211 ? 162.262 106.956 138.135 1.00 80.24  ? 233 GLU B C   1 
ATOM   2215 O O   . GLU B 2 211 ? 162.374 106.146 137.208 1.00 80.24  ? 233 GLU B O   1 
ATOM   2216 C CB  . GLU B 2 211 ? 161.892 106.223 140.511 1.00 80.24  ? 233 GLU B CB  1 
ATOM   2217 C CG  . GLU B 2 211 ? 161.159 107.354 141.213 1.00 80.24  ? 233 GLU B CG  1 
ATOM   2218 C CD  . GLU B 2 211 ? 160.436 106.893 142.462 1.00 80.24  ? 233 GLU B CD  1 
ATOM   2219 O OE1 . GLU B 2 211 ? 160.998 106.061 143.204 1.00 80.24  ? 233 GLU B OE1 1 
ATOM   2220 O OE2 . GLU B 2 211 ? 159.304 107.364 142.701 1.00 80.24  ? 233 GLU B OE2 1 
ATOM   2221 N N   . LEU B 2 212 ? 161.568 108.084 138.009 1.00 75.23  ? 234 LEU B N   1 
ATOM   2222 C CA  . LEU B 2 212 ? 160.900 108.470 136.770 1.00 75.23  ? 234 LEU B CA  1 
ATOM   2223 C C   . LEU B 2 212 ? 161.655 109.648 136.168 1.00 75.23  ? 234 LEU B C   1 
ATOM   2224 O O   . LEU B 2 212 ? 161.595 110.766 136.691 1.00 75.23  ? 234 LEU B O   1 
ATOM   2225 C CB  . LEU B 2 212 ? 159.437 108.825 137.026 1.00 75.23  ? 234 LEU B CB  1 
ATOM   2226 C CG  . LEU B 2 212 ? 158.413 107.727 136.731 1.00 75.23  ? 234 LEU B CG  1 
ATOM   2227 C CD1 . LEU B 2 212 ? 156.997 108.233 136.959 1.00 75.23  ? 234 LEU B CD1 1 
ATOM   2228 C CD2 . LEU B 2 212 ? 158.578 107.205 135.311 1.00 75.23  ? 234 LEU B CD2 1 
ATOM   2229 N N   . SER B 2 213 ? 162.370 109.395 135.072 1.00 68.90  ? 235 SER B N   1 
ATOM   2230 C CA  . SER B 2 213 ? 163.132 110.438 134.400 1.00 68.90  ? 235 SER B CA  1 
ATOM   2231 C C   . SER B 2 213 ? 162.273 111.328 133.512 1.00 68.90  ? 235 SER B C   1 
ATOM   2232 O O   . SER B 2 213 ? 162.773 112.343 133.014 1.00 68.90  ? 235 SER B O   1 
ATOM   2233 C CB  . SER B 2 213 ? 164.252 109.812 133.566 1.00 68.90  ? 235 SER B CB  1 
ATOM   2234 O OG  . SER B 2 213 ? 163.729 108.915 132.603 1.00 68.90  ? 235 SER B OG  1 
ATOM   2235 N N   . SER B 2 214 ? 161.003 110.981 133.303 1.00 66.22  ? 236 SER B N   1 
ATOM   2236 C CA  . SER B 2 214 ? 160.113 111.736 132.433 1.00 66.22  ? 236 SER B CA  1 
ATOM   2237 C C   . SER B 2 214 ? 159.176 112.664 133.200 1.00 66.22  ? 236 SER B C   1 
ATOM   2238 O O   . SER B 2 214 ? 158.170 113.112 132.639 1.00 66.22  ? 236 SER B O   1 
ATOM   2239 C CB  . SER B 2 214 ? 159.301 110.782 131.556 1.00 66.22  ? 236 SER B CB  1 
ATOM   2240 O OG  . SER B 2 214 ? 158.796 109.698 132.315 1.00 66.22  ? 236 SER B OG  1 
ATOM   2241 N N   . ILE B 2 215 ? 159.475 112.961 134.466 1.00 63.69  ? 237 ILE B N   1 
ATOM   2242 C CA  . ILE B 2 215 ? 158.635 113.832 135.275 1.00 63.69  ? 237 ILE B CA  1 
ATOM   2243 C C   . ILE B 2 215 ? 159.493 114.926 135.894 1.00 63.69  ? 237 ILE B C   1 
ATOM   2244 O O   . ILE B 2 215 ? 160.716 114.812 135.996 1.00 63.69  ? 237 ILE B O   1 
ATOM   2245 C CB  . ILE B 2 215 ? 157.876 113.064 136.379 1.00 63.69  ? 237 ILE B CB  1 
ATOM   2246 C CG1 . ILE B 2 215 ? 158.852 112.517 137.422 1.00 63.69  ? 237 ILE B CG1 1 
ATOM   2247 C CG2 . ILE B 2 215 ? 157.041 111.942 135.780 1.00 63.69  ? 237 ILE B CG2 1 
ATOM   2248 C CD1 . ILE B 2 215 ? 158.171 111.897 138.623 1.00 63.69  ? 237 ILE B CD1 1 
ATOM   2249 N N   . LEU B 2 216 ? 158.825 116.000 136.310 1.00 61.77  ? 238 LEU B N   1 
ATOM   2250 C CA  . LEU B 2 216 ? 159.483 117.121 136.979 1.00 61.77  ? 238 LEU B CA  1 
ATOM   2251 C C   . LEU B 2 216 ? 158.499 117.706 137.980 1.00 61.77  ? 238 LEU B C   1 
ATOM   2252 O O   . LEU B 2 216 ? 157.512 118.334 137.584 1.00 61.77  ? 238 LEU B O   1 
ATOM   2253 C CB  . LEU B 2 216 ? 159.936 118.179 135.978 1.00 61.77  ? 238 LEU B CB  1 
ATOM   2254 C CG  . LEU B 2 216 ? 161.264 117.952 135.255 1.00 61.77  ? 238 LEU B CG  1 
ATOM   2255 C CD1 . LEU B 2 216 ? 161.590 119.141 134.368 1.00 61.77  ? 238 LEU B CD1 1 
ATOM   2256 C CD2 . LEU B 2 216 ? 162.381 117.703 136.252 1.00 61.77  ? 238 LEU B CD2 1 
ATOM   2257 N N   . LYS B 2 217 ? 158.764 117.508 139.268 1.00 59.54  ? 239 LYS B N   1 
ATOM   2258 C CA  . LYS B 2 217 ? 157.874 118.002 140.308 1.00 59.54  ? 239 LYS B CA  1 
ATOM   2259 C C   . LYS B 2 217 ? 158.120 119.485 140.549 1.00 59.54  ? 239 LYS B C   1 
ATOM   2260 O O   . LYS B 2 217 ? 159.267 119.919 140.699 1.00 59.54  ? 239 LYS B O   1 
ATOM   2261 C CB  . LYS B 2 217 ? 158.074 117.212 141.601 1.00 59.54  ? 239 LYS B CB  1 
ATOM   2262 C CG  . LYS B 2 217 ? 157.205 117.687 142.753 1.00 59.54  ? 239 LYS B CG  1 
ATOM   2263 C CD  . LYS B 2 217 ? 157.441 116.857 144.003 1.00 59.54  ? 239 LYS B CD  1 
ATOM   2264 C CE  . LYS B 2 217 ? 156.587 117.348 145.158 1.00 59.54  ? 239 LYS B CE  1 
ATOM   2265 N NZ  . LYS B 2 217 ? 156.812 116.549 146.394 1.00 59.54  ? 239 LYS B NZ  1 
ATOM   2266 N N   . LEU B 2 218 ? 157.042 120.260 140.586 1.00 59.29  ? 240 LEU B N   1 
ATOM   2267 C CA  . LEU B 2 218 ? 157.111 121.695 140.815 1.00 59.29  ? 240 LEU B CA  1 
ATOM   2268 C C   . LEU B 2 218 ? 156.860 122.003 142.286 1.00 59.29  ? 240 LEU B C   1 
ATOM   2269 O O   . LEU B 2 218 ? 156.193 121.244 142.993 1.00 59.29  ? 240 LEU B O   1 
ATOM   2270 C CB  . LEU B 2 218 ? 156.093 122.439 139.947 1.00 59.29  ? 240 LEU B CB  1 
ATOM   2271 C CG  . LEU B 2 218 ? 156.512 122.873 138.539 1.00 59.29  ? 240 LEU B CG  1 
ATOM   2272 C CD1 . LEU B 2 218 ? 157.458 124.057 138.609 1.00 59.29  ? 240 LEU B CD1 1 
ATOM   2273 C CD2 . LEU B 2 218 ? 157.136 121.729 137.752 1.00 59.29  ? 240 LEU B CD2 1 
ATOM   2274 N N   . SER B 2 219 ? 157.404 123.128 142.741 1.00 60.85  ? 241 SER B N   1 
ATOM   2275 C CA  . SER B 2 219 ? 157.253 123.542 144.132 1.00 60.85  ? 241 SER B CA  1 
ATOM   2276 C C   . SER B 2 219 ? 157.321 125.058 144.202 1.00 60.85  ? 241 SER B C   1 
ATOM   2277 O O   . SER B 2 219 ? 158.275 125.659 143.699 1.00 60.85  ? 241 SER B O   1 
ATOM   2278 C CB  . SER B 2 219 ? 158.332 122.912 145.015 1.00 60.85  ? 241 SER B CB  1 
ATOM   2279 O OG  . SER B 2 219 ? 158.226 121.500 145.024 1.00 60.85  ? 241 SER B OG  1 
ATOM   2280 N N   . TRP B 2 220 ? 156.316 125.669 144.823 1.00 61.15  ? 242 TRP B N   1 
ATOM   2281 C CA  . TRP B 2 220 ? 156.278 127.114 144.986 1.00 61.15  ? 242 TRP B CA  1 
ATOM   2282 C C   . TRP B 2 220 ? 155.480 127.446 146.237 1.00 61.15  ? 242 TRP B C   1 
ATOM   2283 O O   . TRP B 2 220 ? 154.796 126.594 146.810 1.00 61.15  ? 242 TRP B O   1 
ATOM   2284 C CB  . TRP B 2 220 ? 155.676 127.802 143.756 1.00 61.15  ? 242 TRP B CB  1 
ATOM   2285 C CG  . TRP B 2 220 ? 154.206 127.571 143.601 1.00 61.15  ? 242 TRP B CG  1 
ATOM   2286 C CD1 . TRP B 2 220 ? 153.198 128.369 144.058 1.00 61.15  ? 242 TRP B CD1 1 
ATOM   2287 C CD2 . TRP B 2 220 ? 153.577 126.467 142.942 1.00 61.15  ? 242 TRP B CD2 1 
ATOM   2288 N NE1 . TRP B 2 220 ? 151.980 127.829 143.725 1.00 61.15  ? 242 TRP B NE1 1 
ATOM   2289 C CE2 . TRP B 2 220 ? 152.185 126.661 143.039 1.00 61.15  ? 242 TRP B CE2 1 
ATOM   2290 C CE3 . TRP B 2 220 ? 154.054 125.333 142.280 1.00 61.15  ? 242 TRP B CE3 1 
ATOM   2291 C CZ2 . TRP B 2 220 ? 151.267 125.764 142.499 1.00 61.15  ? 242 TRP B CZ2 1 
ATOM   2292 C CZ3 . TRP B 2 220 ? 153.141 124.444 141.745 1.00 61.15  ? 242 TRP B CZ3 1 
ATOM   2293 C CH2 . TRP B 2 220 ? 151.764 124.664 141.858 1.00 61.15  ? 242 TRP B CH2 1 
ATOM   2294 N N   . VAL B 2 221 ? 155.576 128.703 146.658 1.00 64.46  ? 243 VAL B N   1 
ATOM   2295 C CA  . VAL B 2 221 ? 154.838 129.205 147.809 1.00 64.46  ? 243 VAL B CA  1 
ATOM   2296 C C   . VAL B 2 221 ? 154.055 130.437 147.378 1.00 64.46  ? 243 VAL B C   1 
ATOM   2297 O O   . VAL B 2 221 ? 154.497 131.213 146.525 1.00 64.46  ? 243 VAL B O   1 
ATOM   2298 C CB  . VAL B 2 221 ? 155.777 129.519 148.997 1.00 64.46  ? 243 VAL B CB  1 
ATOM   2299 C CG1 . VAL B 2 221 ? 156.731 130.651 148.649 1.00 64.46  ? 243 VAL B CG1 1 
ATOM   2300 C CG2 . VAL B 2 221 ? 154.976 129.847 150.251 1.00 64.46  ? 243 VAL B CG2 1 
ATOM   2301 N N   . SER B 2 222 ? 152.872 130.603 147.963 1.00 63.85  ? 244 SER B N   1 
ATOM   2302 C CA  . SER B 2 222 ? 151.987 131.711 147.647 1.00 63.85  ? 244 SER B CA  1 
ATOM   2303 C C   . SER B 2 222 ? 151.645 132.480 148.915 1.00 63.85  ? 244 SER B C   1 
ATOM   2304 O O   . SER B 2 222 ? 151.549 131.904 150.003 1.00 63.85  ? 244 SER B O   1 
ATOM   2305 C CB  . SER B 2 222 ? 150.700 131.221 146.973 1.00 63.85  ? 244 SER B CB  1 
ATOM   2306 O OG  . SER B 2 222 ? 150.972 130.653 145.704 1.00 63.85  ? 244 SER B OG  1 
ATOM   2307 N N   . SER B 2 223 ? 151.461 133.792 148.764 1.00 65.49  ? 245 SER B N   1 
ATOM   2308 C CA  . SER B 2 223 ? 151.118 134.629 149.909 1.00 65.49  ? 245 SER B CA  1 
ATOM   2309 C C   . SER B 2 223 ? 149.682 134.381 150.353 1.00 65.49  ? 245 SER B C   1 
ATOM   2310 O O   . SER B 2 223 ? 149.432 133.959 151.488 1.00 65.49  ? 245 SER B O   1 
ATOM   2311 C CB  . SER B 2 223 ? 151.335 136.102 149.562 1.00 65.49  ? 245 SER B CB  1 
ATOM   2312 O OG  . SER B 2 223 ? 152.569 136.291 148.892 1.00 65.49  ? 245 SER B OG  1 
ATOM   2313 N N   . GLY B 2 224 ? 148.723 134.634 149.465 1.00 64.34  ? 246 GLY B N   1 
ATOM   2314 C CA  . GLY B 2 224 ? 147.326 134.395 149.776 1.00 64.34  ? 246 GLY B CA  1 
ATOM   2315 C C   . GLY B 2 224 ? 146.779 135.215 150.920 1.00 64.34  ? 246 GLY B C   1 
ATOM   2316 O O   . GLY B 2 224 ? 145.813 134.795 151.563 1.00 64.34  ? 246 GLY B O   1 
ATOM   2317 N N   . LEU B 2 225 ? 147.374 136.379 151.193 1.00 62.66  ? 247 LEU B N   1 
ATOM   2318 C CA  . LEU B 2 225 ? 146.940 137.259 152.282 1.00 62.66  ? 247 LEU B CA  1 
ATOM   2319 C C   . LEU B 2 225 ? 146.960 136.532 153.625 1.00 62.66  ? 247 LEU B C   1 
ATOM   2320 O O   . LEU B 2 225 ? 146.081 136.721 154.468 1.00 62.66  ? 247 LEU B O   1 
ATOM   2321 C CB  . LEU B 2 225 ? 145.555 137.849 152.006 1.00 62.66  ? 247 LEU B CB  1 
ATOM   2322 C CG  . LEU B 2 225 ? 145.448 139.007 151.010 1.00 62.66  ? 247 LEU B CG  1 
ATOM   2323 C CD1 . LEU B 2 225 ? 145.549 138.517 149.574 1.00 62.66  ? 247 LEU B CD1 1 
ATOM   2324 C CD2 . LEU B 2 225 ? 144.150 139.764 151.225 1.00 62.66  ? 247 LEU B CD2 1 
ATOM   2325 N N   . GLY B 2 226 ? 147.971 135.691 153.825 1.00 64.49  ? 248 GLY B N   1 
ATOM   2326 C CA  . GLY B 2 226 ? 148.076 134.937 155.057 1.00 64.49  ? 248 GLY B CA  1 
ATOM   2327 C C   . GLY B 2 226 ? 147.175 133.728 155.135 1.00 64.49  ? 248 GLY B C   1 
ATOM   2328 O O   . GLY B 2 226 ? 146.778 133.330 156.234 1.00 64.49  ? 248 GLY B O   1 
ATOM   2329 N N   . GLY B 2 227 ? 146.835 133.129 153.996 1.00 63.79  ? 249 GLY B N   1 
ATOM   2330 C CA  . GLY B 2 227 ? 145.971 131.968 153.987 1.00 63.79  ? 249 GLY B CA  1 
ATOM   2331 C C   . GLY B 2 227 ? 144.495 132.276 153.920 1.00 63.79  ? 249 GLY B C   1 
ATOM   2332 O O   . GLY B 2 227 ? 143.683 131.477 154.402 1.00 63.79  ? 249 GLY B O   1 
ATOM   2333 N N   . LEU B 2 228 ? 144.116 133.411 153.336 1.00 60.18  ? 250 LEU B N   1 
ATOM   2334 C CA  . LEU B 2 228 ? 142.720 133.820 153.260 1.00 60.18  ? 250 LEU B CA  1 
ATOM   2335 C C   . LEU B 2 228 ? 142.065 133.486 151.927 1.00 60.18  ? 250 LEU B C   1 
ATOM   2336 O O   . LEU B 2 228 ? 140.867 133.185 151.899 1.00 60.18  ? 250 LEU B O   1 
ATOM   2337 C CB  . LEU B 2 228 ? 142.601 135.326 153.517 1.00 60.18  ? 250 LEU B CB  1 
ATOM   2338 C CG  . LEU B 2 228 ? 141.197 135.934 153.540 1.00 60.18  ? 250 LEU B CG  1 
ATOM   2339 C CD1 . LEU B 2 228 ? 140.314 135.206 154.538 1.00 60.18  ? 250 LEU B CD1 1 
ATOM   2340 C CD2 . LEU B 2 228 ? 141.265 137.418 153.863 1.00 60.18  ? 250 LEU B CD2 1 
ATOM   2341 N N   . LEU B 2 229 ? 142.815 133.522 150.830 1.00 59.14  ? 251 LEU B N   1 
ATOM   2342 C CA  . LEU B 2 229 ? 142.275 133.308 149.494 1.00 59.14  ? 251 LEU B CA  1 
ATOM   2343 C C   . LEU B 2 229 ? 142.784 131.990 148.929 1.00 59.14  ? 251 LEU B C   1 
ATOM   2344 O O   . LEU B 2 229 ? 143.992 131.733 148.934 1.00 59.14  ? 251 LEU B O   1 
ATOM   2345 C CB  . LEU B 2 229 ? 142.660 134.457 148.561 1.00 59.14  ? 251 LEU B CB  1 
ATOM   2346 C CG  . LEU B 2 229 ? 142.020 135.814 148.847 1.00 59.14  ? 251 LEU B CG  1 
ATOM   2347 C CD1 . LEU B 2 229 ? 142.638 136.882 147.965 1.00 59.14  ? 251 LEU B CD1 1 
ATOM   2348 C CD2 . LEU B 2 229 ? 140.516 135.748 148.641 1.00 59.14  ? 251 LEU B CD2 1 
ATOM   2349 N N   . ASP B 2 230 ? 141.862 131.162 148.445 1.00 59.09  ? 252 ASP B N   1 
ATOM   2350 C CA  . ASP B 2 230 ? 142.220 129.942 147.729 1.00 59.09  ? 252 ASP B CA  1 
ATOM   2351 C C   . ASP B 2 230 ? 142.543 130.310 146.286 1.00 59.09  ? 252 ASP B C   1 
ATOM   2352 O O   . ASP B 2 230 ? 141.652 130.694 145.522 1.00 59.09  ? 252 ASP B O   1 
ATOM   2353 C CB  . ASP B 2 230 ? 141.085 128.924 147.800 1.00 59.09  ? 252 ASP B CB  1 
ATOM   2354 C CG  . ASP B 2 230 ? 140.817 128.451 149.214 1.00 59.09  ? 252 ASP B CG  1 
ATOM   2355 O OD1 . ASP B 2 230 ? 141.747 128.499 150.046 1.00 59.09  ? 252 ASP B OD1 1 
ATOM   2356 O OD2 . ASP B 2 230 ? 139.676 128.027 149.495 1.00 59.09  ? 252 ASP B OD2 1 
ATOM   2357 N N   . LEU B 2 231 ? 143.814 130.201 145.912 1.00 54.12  ? 253 LEU B N   1 
ATOM   2358 C CA  . LEU B 2 231 ? 144.289 130.655 144.612 1.00 54.12  ? 253 LEU B CA  1 
ATOM   2359 C C   . LEU B 2 231 ? 144.554 129.468 143.698 1.00 54.12  ? 253 LEU B C   1 
ATOM   2360 O O   . LEU B 2 231 ? 145.212 128.503 144.100 1.00 54.12  ? 253 LEU B O   1 
ATOM   2361 C CB  . LEU B 2 231 ? 145.563 131.489 144.764 1.00 54.12  ? 253 LEU B CB  1 
ATOM   2362 C CG  . LEU B 2 231 ? 145.496 132.688 145.710 1.00 54.12  ? 253 LEU B CG  1 
ATOM   2363 C CD1 . LEU B 2 231 ? 146.854 133.362 145.812 1.00 54.12  ? 253 LEU B CD1 1 
ATOM   2364 C CD2 . LEU B 2 231 ? 144.439 133.675 145.248 1.00 54.12  ? 253 LEU B CD2 1 
ATOM   2365 N N   . LYS B 2 232 ? 144.039 129.541 142.474 1.00 52.47  ? 254 LYS B N   1 
ATOM   2366 C CA  . LYS B 2 232 ? 144.386 128.600 141.421 1.00 52.47  ? 254 LYS B CA  1 
ATOM   2367 C C   . LYS B 2 232 ? 145.449 129.218 140.521 1.00 52.47  ? 254 LYS B C   1 
ATOM   2368 O O   . LYS B 2 232 ? 145.525 130.440 140.371 1.00 52.47  ? 254 LYS B O   1 
ATOM   2369 C CB  . LYS B 2 232 ? 143.155 128.203 140.603 1.00 52.47  ? 254 LYS B CB  1 
ATOM   2370 C CG  . LYS B 2 232 ? 142.588 129.308 139.730 1.00 52.47  ? 254 LYS B CG  1 
ATOM   2371 C CD  . LYS B 2 232 ? 141.449 128.788 138.869 1.00 52.47  ? 254 LYS B CD  1 
ATOM   2372 C CE  . LYS B 2 232 ? 140.932 129.859 137.924 1.00 52.47  ? 254 LYS B CE  1 
ATOM   2373 N NZ  . LYS B 2 232 ? 139.825 129.355 137.067 1.00 52.47  ? 254 LYS B NZ  1 
ATOM   2374 N N   . SER B 2 233 ? 146.276 128.364 139.926 1.00 53.94  ? 255 SER B N   1 
ATOM   2375 C CA  . SER B 2 233 ? 147.466 128.810 139.221 1.00 53.94  ? 255 SER B CA  1 
ATOM   2376 C C   . SER B 2 233 ? 147.432 128.387 137.758 1.00 53.94  ? 255 SER B C   1 
ATOM   2377 O O   . SER B 2 233 ? 146.657 127.517 137.353 1.00 53.94  ? 255 SER B O   1 
ATOM   2378 C CB  . SER B 2 233 ? 148.734 128.262 139.888 1.00 53.94  ? 255 SER B CB  1 
ATOM   2379 O OG  . SER B 2 233 ? 148.587 126.890 140.208 1.00 53.94  ? 255 SER B OG  1 
ATOM   2380 N N   . ASP B 2 234 ? 148.294 129.028 136.970 1.00 55.91  ? 256 ASP B N   1 
ATOM   2381 C CA  . ASP B 2 234 ? 148.480 128.715 135.558 1.00 55.91  ? 256 ASP B CA  1 
ATOM   2382 C C   . ASP B 2 234 ? 149.964 128.485 135.317 1.00 55.91  ? 256 ASP B C   1 
ATOM   2383 O O   . ASP B 2 234 ? 150.778 129.382 135.562 1.00 55.91  ? 256 ASP B O   1 
ATOM   2384 C CB  . ASP B 2 234 ? 147.956 129.842 134.665 1.00 55.91  ? 256 ASP B CB  1 
ATOM   2385 C CG  . ASP B 2 234 ? 147.991 129.485 133.192 1.00 55.91  ? 256 ASP B CG  1 
ATOM   2386 O OD1 . ASP B 2 234 ? 148.187 128.294 132.871 1.00 55.91  ? 256 ASP B OD1 1 
ATOM   2387 O OD2 . ASP B 2 234 ? 147.823 130.395 132.354 1.00 55.91  ? 256 ASP B OD2 1 
ATOM   2388 N N   . ILE B 2 235 ? 150.314 127.295 134.838 1.00 59.27  ? 257 ILE B N   1 
ATOM   2389 C CA  . ILE B 2 235 ? 151.703 126.879 134.677 1.00 59.27  ? 257 ILE B CA  1 
ATOM   2390 C C   . ILE B 2 235 ? 152.019 126.780 133.192 1.00 59.27  ? 257 ILE B C   1 
ATOM   2391 O O   . ILE B 2 235 ? 151.293 126.121 132.438 1.00 59.27  ? 257 ILE B O   1 
ATOM   2392 C CB  . ILE B 2 235 ? 151.971 125.539 135.383 1.00 59.27  ? 257 ILE B CB  1 
ATOM   2393 C CG1 . ILE B 2 235 ? 151.613 125.638 136.867 1.00 59.27  ? 257 ILE B CG1 1 
ATOM   2394 C CG2 . ILE B 2 235 ? 153.424 125.128 135.210 1.00 59.27  ? 257 ILE B CG2 1 
ATOM   2395 C CD1 . ILE B 2 235 ? 151.795 124.344 137.626 1.00 59.27  ? 257 ILE B CD1 1 
ATOM   2396 N N   . GLN B 2 236 ? 153.103 127.430 132.776 1.00 58.40  ? 258 GLN B N   1 
ATOM   2397 C CA  . GLN B 2 236 ? 153.602 127.352 131.411 1.00 58.40  ? 258 GLN B CA  1 
ATOM   2398 C C   . GLN B 2 236 ? 155.052 126.893 131.428 1.00 58.40  ? 258 GLN B C   1 
ATOM   2399 O O   . GLN B 2 236 ? 155.854 127.371 132.236 1.00 58.40  ? 258 GLN B O   1 
ATOM   2400 C CB  . GLN B 2 236 ? 153.491 128.702 130.696 1.00 58.40  ? 258 GLN B CB  1 
ATOM   2401 C CG  . GLN B 2 236 ? 152.074 129.091 130.316 1.00 58.40  ? 258 GLN B CG  1 
ATOM   2402 C CD  . GLN B 2 236 ? 152.025 130.350 129.474 1.00 58.40  ? 258 GLN B CD  1 
ATOM   2403 O OE1 . GLN B 2 236 ? 153.038 131.022 129.282 1.00 58.40  ? 258 GLN B OE1 1 
ATOM   2404 N NE2 . GLN B 2 236 ? 150.843 130.675 128.964 1.00 58.40  ? 258 GLN B NE2 1 
ATOM   2405 N N   . TYR B 2 237 ? 155.386 125.967 130.532 1.00 58.95  ? 259 TYR B N   1 
ATOM   2406 C CA  . TYR B 2 237 ? 156.725 125.405 130.455 1.00 58.95  ? 259 TYR B CA  1 
ATOM   2407 C C   . TYR B 2 237 ? 157.205 125.403 129.011 1.00 58.95  ? 259 TYR B C   1 
ATOM   2408 O O   . TYR B 2 237 ? 156.404 125.397 128.073 1.00 58.95  ? 259 TYR B O   1 
ATOM   2409 C CB  . TYR B 2 237 ? 156.773 123.978 131.019 1.00 58.95  ? 259 TYR B CB  1 
ATOM   2410 C CG  . TYR B 2 237 ? 156.131 122.936 130.130 1.00 58.95  ? 259 TYR B CG  1 
ATOM   2411 C CD1 . TYR B 2 237 ? 154.755 122.760 130.117 1.00 58.95  ? 259 TYR B CD1 1 
ATOM   2412 C CD2 . TYR B 2 237 ? 156.903 122.121 129.313 1.00 58.95  ? 259 TYR B CD2 1 
ATOM   2413 C CE1 . TYR B 2 237 ? 154.166 121.807 129.309 1.00 58.95  ? 259 TYR B CE1 1 
ATOM   2414 C CE2 . TYR B 2 237 ? 156.322 121.167 128.502 1.00 58.95  ? 259 TYR B CE2 1 
ATOM   2415 C CZ  . TYR B 2 237 ? 154.954 121.013 128.504 1.00 58.95  ? 259 TYR B CZ  1 
ATOM   2416 O OH  . TYR B 2 237 ? 154.371 120.063 127.698 1.00 58.95  ? 259 TYR B OH  1 
ATOM   2417 N N   . ARG B 2 238 ? 158.524 125.404 128.846 1.00 63.09  ? 260 ARG B N   1 
ATOM   2418 C CA  . ARG B 2 238 ? 159.138 125.369 127.527 1.00 63.09  ? 260 ARG B CA  1 
ATOM   2419 C C   . ARG B 2 238 ? 160.564 124.858 127.674 1.00 63.09  ? 260 ARG B C   1 
ATOM   2420 O O   . ARG B 2 238 ? 161.100 124.763 128.779 1.00 63.09  ? 260 ARG B O   1 
ATOM   2421 C CB  . ARG B 2 238 ? 159.121 126.747 126.861 1.00 63.09  ? 260 ARG B CB  1 
ATOM   2422 C CG  . ARG B 2 238 ? 160.129 127.717 127.449 1.00 63.09  ? 260 ARG B CG  1 
ATOM   2423 C CD  . ARG B 2 238 ? 160.382 128.895 126.523 1.00 63.09  ? 260 ARG B CD  1 
ATOM   2424 N NE  . ARG B 2 238 ? 161.476 129.734 127.005 1.00 63.09  ? 260 ARG B NE  1 
ATOM   2425 C CZ  . ARG B 2 238 ? 161.928 130.810 126.372 1.00 63.09  ? 260 ARG B CZ  1 
ATOM   2426 N NH1 . ARG B 2 238 ? 161.381 131.185 125.224 1.00 63.09  ? 260 ARG B NH1 1 
ATOM   2427 N NH2 . ARG B 2 238 ? 162.927 131.513 126.887 1.00 63.09  ? 260 ARG B NH2 1 
ATOM   2428 N N   . THR B 2 239 ? 161.172 124.531 126.538 1.00 66.88  ? 261 THR B N   1 
ATOM   2429 C CA  . THR B 2 239 ? 162.558 124.086 126.512 1.00 66.88  ? 261 THR B CA  1 
ATOM   2430 C C   . THR B 2 239 ? 163.464 125.318 126.583 1.00 66.88  ? 261 THR B C   1 
ATOM   2431 O O   . THR B 2 239 ? 163.005 126.440 126.812 1.00 66.88  ? 261 THR B O   1 
ATOM   2432 C CB  . THR B 2 239 ? 162.811 123.231 125.271 1.00 66.88  ? 261 THR B CB  1 
ATOM   2433 O OG1 . THR B 2 239 ? 161.642 122.453 124.986 1.00 66.88  ? 261 THR B OG1 1 
ATOM   2434 C CG2 . THR B 2 239 ? 163.977 122.273 125.497 1.00 66.88  ? 261 THR B CG2 1 
ATOM   2435 N N   . LYS B 2 240 ? 164.769 125.128 126.394 1.00 70.05  ? 262 LYS B N   1 
ATOM   2436 C CA  . LYS B 2 240 ? 165.712 126.236 126.436 1.00 70.05  ? 262 LYS B CA  1 
ATOM   2437 C C   . LYS B 2 240 ? 165.996 126.841 125.067 1.00 70.05  ? 262 LYS B C   1 
ATOM   2438 O O   . LYS B 2 240 ? 166.459 127.984 124.998 1.00 70.05  ? 262 LYS B O   1 
ATOM   2439 C CB  . LYS B 2 240 ? 167.033 125.784 127.069 1.00 70.05  ? 262 LYS B CB  1 
ATOM   2440 C CG  . LYS B 2 240 ? 167.843 126.915 127.679 1.00 70.05  ? 262 LYS B CG  1 
ATOM   2441 C CD  . LYS B 2 240 ? 169.108 126.396 128.336 1.00 70.05  ? 262 LYS B CD  1 
ATOM   2442 C CE  . LYS B 2 240 ? 169.772 127.474 129.174 1.00 70.05  ? 262 LYS B CE  1 
ATOM   2443 N NZ  . LYS B 2 240 ? 170.930 126.944 129.943 1.00 70.05  ? 262 LYS B NZ  1 
ATOM   2444 N N   . ASP B 2 241 ? 165.726 126.111 123.985 1.00 74.22  ? 263 ASP B N   1 
ATOM   2445 C CA  . ASP B 2 241 ? 165.993 126.604 122.640 1.00 74.22  ? 263 ASP B CA  1 
ATOM   2446 C C   . ASP B 2 241 ? 164.752 127.120 121.925 1.00 74.22  ? 263 ASP B C   1 
ATOM   2447 O O   . ASP B 2 241 ? 164.887 127.862 120.947 1.00 74.22  ? 263 ASP B O   1 
ATOM   2448 C CB  . ASP B 2 241 ? 166.637 125.503 121.790 1.00 74.22  ? 263 ASP B CB  1 
ATOM   2449 C CG  . ASP B 2 241 ? 165.979 124.152 121.990 1.00 74.22  ? 263 ASP B CG  1 
ATOM   2450 O OD1 . ASP B 2 241 ? 165.057 124.057 122.827 1.00 74.22  ? 263 ASP B OD1 1 
ATOM   2451 O OD2 . ASP B 2 241 ? 166.383 123.184 121.312 1.00 74.22  ? 263 ASP B OD2 1 
ATOM   2452 N N   . ALA B 2 242 ? 163.560 126.752 122.382 1.00 70.37  ? 264 ALA B N   1 
ATOM   2453 C CA  . ALA B 2 242 ? 162.327 127.176 121.739 1.00 70.37  ? 264 ALA B CA  1 
ATOM   2454 C C   . ALA B 2 242 ? 161.833 128.486 122.337 1.00 70.37  ? 264 ALA B C   1 
ATOM   2455 O O   . ALA B 2 242 ? 162.077 128.791 123.507 1.00 70.37  ? 264 ALA B O   1 
ATOM   2456 C CB  . ALA B 2 242 ? 161.248 126.100 121.875 1.00 70.37  ? 264 ALA B CB  1 
ATOM   2457 N N   . SER B 2 243 ? 161.130 129.264 121.514 1.00 70.03  ? 265 SER B N   1 
ATOM   2458 C CA  . SER B 2 243 ? 160.582 130.545 121.939 1.00 70.03  ? 265 SER B CA  1 
ATOM   2459 C C   . SER B 2 243 ? 159.113 130.471 122.327 1.00 70.03  ? 265 SER B C   1 
ATOM   2460 O O   . SER B 2 243 ? 158.660 131.276 123.147 1.00 70.03  ? 265 SER B O   1 
ATOM   2461 C CB  . SER B 2 243 ? 160.753 131.589 120.830 1.00 70.03  ? 265 SER B CB  1 
ATOM   2462 O OG  . SER B 2 243 ? 160.027 131.224 119.669 1.00 70.03  ? 265 SER B OG  1 
ATOM   2463 N N   . THR B 2 244 ? 158.363 129.531 121.761 1.00 68.77  ? 266 THR B N   1 
ATOM   2464 C CA  . THR B 2 244 ? 156.958 129.378 122.104 1.00 68.77  ? 266 THR B CA  1 
ATOM   2465 C C   . THR B 2 244 ? 156.810 128.686 123.453 1.00 68.77  ? 266 THR B C   1 
ATOM   2466 O O   . THR B 2 244 ? 157.649 127.875 123.857 1.00 68.77  ? 266 THR B O   1 
ATOM   2467 C CB  . THR B 2 244 ? 156.223 128.578 121.028 1.00 68.77  ? 266 THR B CB  1 
ATOM   2468 O OG1 . THR B 2 244 ? 156.484 127.180 121.208 1.00 68.77  ? 266 THR B OG1 1 
ATOM   2469 C CG2 . THR B 2 244 ? 156.688 128.999 119.643 1.00 68.77  ? 266 THR B CG2 1 
ATOM   2470 N N   . TRP B 2 245 ? 155.729 129.015 124.151 1.00 61.40  ? 267 TRP B N   1 
ATOM   2471 C CA  . TRP B 2 245 ? 155.435 128.460 125.464 1.00 61.40  ? 267 TRP B CA  1 
ATOM   2472 C C   . TRP B 2 245 ? 154.255 127.505 125.357 1.00 61.40  ? 267 TRP B C   1 
ATOM   2473 O O   . TRP B 2 245 ? 153.219 127.855 124.781 1.00 61.40  ? 267 TRP B O   1 
ATOM   2474 C CB  . TRP B 2 245 ? 155.129 129.569 126.472 1.00 61.40  ? 267 TRP B CB  1 
ATOM   2475 C CG  . TRP B 2 245 ? 156.288 130.477 126.735 1.00 61.40  ? 267 TRP B CG  1 
ATOM   2476 C CD1 . TRP B 2 245 ? 156.673 131.550 125.988 1.00 61.40  ? 267 TRP B CD1 1 
ATOM   2477 C CD2 . TRP B 2 245 ? 157.211 130.397 127.828 1.00 61.40  ? 267 TRP B CD2 1 
ATOM   2478 N NE1 . TRP B 2 245 ? 157.781 132.142 126.545 1.00 61.40  ? 267 TRP B NE1 1 
ATOM   2479 C CE2 . TRP B 2 245 ? 158.130 131.453 127.676 1.00 61.40  ? 267 TRP B CE2 1 
ATOM   2480 C CE3 . TRP B 2 245 ? 157.349 129.534 128.919 1.00 61.40  ? 267 TRP B CE3 1 
ATOM   2481 C CZ2 . TRP B 2 245 ? 159.173 131.669 128.573 1.00 61.40  ? 267 TRP B CZ2 1 
ATOM   2482 C CZ3 . TRP B 2 245 ? 158.385 129.751 129.809 1.00 61.40  ? 267 TRP B CZ3 1 
ATOM   2483 C CH2 . TRP B 2 245 ? 159.283 130.809 129.630 1.00 61.40  ? 267 TRP B CH2 1 
ATOM   2484 N N   . ILE B 2 246 ? 154.414 126.308 125.910 1.00 60.06  ? 268 ILE B N   1 
ATOM   2485 C CA  . ILE B 2 246 ? 153.362 125.299 125.927 1.00 60.06  ? 268 ILE B CA  1 
ATOM   2486 C C   . ILE B 2 246 ? 152.650 125.386 127.268 1.00 60.06  ? 268 ILE B C   1 
ATOM   2487 O O   . ILE B 2 246 ? 153.286 125.297 128.325 1.00 60.06  ? 268 ILE B O   1 
ATOM   2488 C CB  . ILE B 2 246 ? 153.928 123.891 125.689 1.00 60.06  ? 268 ILE B CB  1 
ATOM   2489 C CG1 . ILE B 2 246 ? 154.791 123.868 124.427 1.00 60.06  ? 268 ILE B CG1 1 
ATOM   2490 C CG2 . ILE B 2 246 ? 152.800 122.876 125.586 1.00 60.06  ? 268 ILE B CG2 1 
ATOM   2491 C CD1 . ILE B 2 246 ? 156.277 123.807 124.702 1.00 60.06  ? 268 ILE B CD1 1 
ATOM   2492 N N   . GLN B 2 247 ? 151.333 125.561 127.230 1.00 62.51  ? 269 GLN B N   1 
ATOM   2493 C CA  . GLN B 2 247 ? 150.529 125.708 128.434 1.00 62.51  ? 269 GLN B CA  1 
ATOM   2494 C C   . GLN B 2 247 ? 149.842 124.388 128.758 1.00 62.51  ? 269 GLN B C   1 
ATOM   2495 O O   . GLN B 2 247 ? 149.267 123.748 127.872 1.00 62.51  ? 269 GLN B O   1 
ATOM   2496 C CB  . GLN B 2 247 ? 149.489 126.817 128.266 1.00 62.51  ? 269 GLN B CB  1 
ATOM   2497 C CG  . GLN B 2 247 ? 148.649 127.068 129.506 1.00 62.51  ? 269 GLN B CG  1 
ATOM   2498 C CD  . GLN B 2 247 ? 147.651 128.192 129.316 1.00 62.51  ? 269 GLN B CD  1 
ATOM   2499 O OE1 . GLN B 2 247 ? 147.574 128.793 128.245 1.00 62.51  ? 269 GLN B OE1 1 
ATOM   2500 N NE2 . GLN B 2 247 ? 146.881 128.482 130.358 1.00 62.51  ? 269 GLN B NE2 1 
ATOM   2501 N N   . VAL B 2 248 ? 149.908 123.988 130.023 1.00 64.96  ? 270 VAL B N   1 
ATOM   2502 C CA  . VAL B 2 248 ? 149.255 122.770 130.494 1.00 64.96  ? 270 VAL B CA  1 
ATOM   2503 C C   . VAL B 2 248 ? 147.751 123.016 130.533 1.00 64.96  ? 270 VAL B C   1 
ATOM   2504 O O   . VAL B 2 248 ? 147.321 124.177 130.591 1.00 64.96  ? 270 VAL B O   1 
ATOM   2505 C CB  . VAL B 2 248 ? 149.794 122.349 131.870 1.00 64.96  ? 270 VAL B CB  1 
ATOM   2506 C CG1 . VAL B 2 248 ? 151.290 122.089 131.794 1.00 64.96  ? 270 VAL B CG1 1 
ATOM   2507 C CG2 . VAL B 2 248 ? 149.487 123.415 132.909 1.00 64.96  ? 270 VAL B CG2 1 
ATOM   2508 N N   . PRO B 2 249 ? 146.920 121.975 130.483 1.00 68.77  ? 271 PRO B N   1 
ATOM   2509 C CA  . PRO B 2 249 ? 145.469 122.189 130.574 1.00 68.77  ? 271 PRO B CA  1 
ATOM   2510 C C   . PRO B 2 249 ? 145.091 122.857 131.888 1.00 68.77  ? 271 PRO B C   1 
ATOM   2511 O O   . PRO B 2 249 ? 145.484 122.413 132.969 1.00 68.77  ? 271 PRO B O   1 
ATOM   2512 C CB  . PRO B 2 249 ? 144.896 120.771 130.472 1.00 68.77  ? 271 PRO B CB  1 
ATOM   2513 C CG  . PRO B 2 249 ? 145.942 119.995 129.747 1.00 68.77  ? 271 PRO B CG  1 
ATOM   2514 C CD  . PRO B 2 249 ? 147.253 120.569 130.196 1.00 68.77  ? 271 PRO B CD  1 
ATOM   2515 N N   . LEU B 2 250 ? 144.318 123.940 131.783 1.00 69.54  ? 272 LEU B N   1 
ATOM   2516 C CA  . LEU B 2 250 ? 143.959 124.723 132.959 1.00 69.54  ? 272 LEU B CA  1 
ATOM   2517 C C   . LEU B 2 250 ? 143.039 123.965 133.908 1.00 69.54  ? 272 LEU B C   1 
ATOM   2518 O O   . LEU B 2 250 ? 142.957 124.324 135.087 1.00 69.54  ? 272 LEU B O   1 
ATOM   2519 C CB  . LEU B 2 250 ? 143.304 126.037 132.530 1.00 69.54  ? 272 LEU B CB  1 
ATOM   2520 C CG  . LEU B 2 250 ? 143.259 127.155 133.573 1.00 69.54  ? 272 LEU B CG  1 
ATOM   2521 C CD1 . LEU B 2 250 ? 144.663 127.508 134.035 1.00 69.54  ? 272 LEU B CD1 1 
ATOM   2522 C CD2 . LEU B 2 250 ? 142.551 128.380 133.019 1.00 69.54  ? 272 LEU B CD2 1 
ATOM   2523 N N   . GLU B 2 251 ? 142.350 122.929 133.426 1.00 73.07  ? 273 GLU B N   1 
ATOM   2524 C CA  . GLU B 2 251 ? 141.466 122.164 134.301 1.00 73.07  ? 273 GLU B CA  1 
ATOM   2525 C C   . GLU B 2 251 ? 142.249 121.351 135.324 1.00 73.07  ? 273 GLU B C   1 
ATOM   2526 O O   . GLU B 2 251 ? 141.721 121.032 136.395 1.00 73.07  ? 273 GLU B O   1 
ATOM   2527 C CB  . GLU B 2 251 ? 140.566 121.249 133.472 1.00 73.07  ? 273 GLU B CB  1 
ATOM   2528 C CG  . GLU B 2 251 ? 141.271 120.561 132.316 1.00 73.07  ? 273 GLU B CG  1 
ATOM   2529 C CD  . GLU B 2 251 ? 141.103 121.303 131.005 1.00 73.07  ? 273 GLU B CD  1 
ATOM   2530 O OE1 . GLU B 2 251 ? 141.159 122.551 131.016 1.00 73.07  ? 273 GLU B OE1 1 
ATOM   2531 O OE2 . GLU B 2 251 ? 140.914 120.639 129.965 1.00 73.07  ? 273 GLU B OE2 1 
ATOM   2532 N N   . ASP B 2 252 ? 143.501 121.006 135.017 1.00 72.32  ? 274 ASP B N   1 
ATOM   2533 C CA  . ASP B 2 252 ? 144.308 120.201 135.925 1.00 72.32  ? 274 ASP B CA  1 
ATOM   2534 C C   . ASP B 2 252 ? 144.866 121.002 137.094 1.00 72.32  ? 274 ASP B C   1 
ATOM   2535 O O   . ASP B 2 252 ? 145.274 120.405 138.095 1.00 72.32  ? 274 ASP B O   1 
ATOM   2536 C CB  . ASP B 2 252 ? 145.459 119.542 135.163 1.00 72.32  ? 274 ASP B CB  1 
ATOM   2537 C CG  . ASP B 2 252 ? 144.977 118.661 134.028 1.00 72.32  ? 274 ASP B CG  1 
ATOM   2538 O OD1 . ASP B 2 252 ? 143.873 118.090 134.145 1.00 72.32  ? 274 ASP B OD1 1 
ATOM   2539 O OD2 . ASP B 2 252 ? 145.702 118.540 133.019 1.00 72.32  ? 274 ASP B OD2 1 
ATOM   2540 N N   . THR B 2 253 ? 144.897 122.328 136.993 1.00 67.69  ? 275 THR B N   1 
ATOM   2541 C CA  . THR B 2 253 ? 145.448 123.192 138.030 1.00 67.69  ? 275 THR B CA  1 
ATOM   2542 C C   . THR B 2 253 ? 144.370 124.092 138.623 1.00 67.69  ? 275 THR B C   1 
ATOM   2543 O O   . THR B 2 253 ? 144.591 125.281 138.864 1.00 67.69  ? 275 THR B O   1 
ATOM   2544 C CB  . THR B 2 253 ? 146.602 124.031 137.485 1.00 67.69  ? 275 THR B CB  1 
ATOM   2545 O OG1 . THR B 2 253 ? 146.108 124.938 136.492 1.00 67.69  ? 275 THR B OG1 1 
ATOM   2546 C CG2 . THR B 2 253 ? 147.660 123.137 136.860 1.00 67.69  ? 275 THR B CG2 1 
ATOM   2547 N N   . MET B 2 254 ? 143.186 123.533 138.866 1.00 67.51  ? 276 MET B N   1 
ATOM   2548 C CA  . MET B 2 254 ? 142.090 124.303 139.441 1.00 67.51  ? 276 MET B CA  1 
ATOM   2549 C C   . MET B 2 254 ? 142.020 124.192 140.957 1.00 67.51  ? 276 MET B C   1 
ATOM   2550 O O   . MET B 2 254 ? 141.553 125.128 141.617 1.00 67.51  ? 276 MET B O   1 
ATOM   2551 C CB  . MET B 2 254 ? 140.756 123.857 138.835 1.00 67.51  ? 276 MET B CB  1 
ATOM   2552 C CG  . MET B 2 254 ? 140.626 124.144 137.349 1.00 67.51  ? 276 MET B CG  1 
ATOM   2553 S SD  . MET B 2 254 ? 138.992 123.750 136.697 1.00 67.51  ? 276 MET B SD  1 
ATOM   2554 C CE  . MET B 2 254 ? 137.978 124.925 137.592 1.00 67.51  ? 276 MET B CE  1 
ATOM   2555 N N   . SER B 2 255 ? 142.469 123.077 141.524 1.00 65.22  ? 277 SER B N   1 
ATOM   2556 C CA  . SER B 2 255 ? 142.418 122.906 142.969 1.00 65.22  ? 277 SER B CA  1 
ATOM   2557 C C   . SER B 2 255 ? 143.547 123.689 143.636 1.00 65.22  ? 277 SER B C   1 
ATOM   2558 O O   . SER B 2 255 ? 144.652 123.769 143.093 1.00 65.22  ? 277 SER B O   1 
ATOM   2559 C CB  . SER B 2 255 ? 142.523 121.429 143.339 1.00 65.22  ? 277 SER B CB  1 
ATOM   2560 O OG  . SER B 2 255 ? 142.756 121.267 144.727 1.00 65.22  ? 277 SER B OG  1 
ATOM   2561 N N   . PRO B 2 256 ? 143.296 124.278 144.806 1.00 64.45  ? 278 PRO B N   1 
ATOM   2562 C CA  . PRO B 2 256 ? 144.358 125.004 145.522 1.00 64.45  ? 278 PRO B CA  1 
ATOM   2563 C C   . PRO B 2 256 ? 145.454 124.049 145.970 1.00 64.45  ? 278 PRO B C   1 
ATOM   2564 O O   . PRO B 2 256 ? 145.204 123.108 146.725 1.00 64.45  ? 278 PRO B O   1 
ATOM   2565 C CB  . PRO B 2 256 ? 143.623 125.625 146.717 1.00 64.45  ? 278 PRO B CB  1 
ATOM   2566 C CG  . PRO B 2 256 ? 142.172 125.599 146.340 1.00 64.45  ? 278 PRO B CG  1 
ATOM   2567 C CD  . PRO B 2 256 ? 141.999 124.382 145.492 1.00 64.45  ? 278 PRO B CD  1 
ATOM   2568 N N   . ARG B 2 257 ? 146.674 124.298 145.500 1.00 66.60  ? 279 ARG B N   1 
ATOM   2569 C CA  . ARG B 2 257 ? 147.804 123.437 145.816 1.00 66.60  ? 279 ARG B CA  1 
ATOM   2570 C C   . ARG B 2 257 ? 149.087 124.237 145.658 1.00 66.60  ? 279 ARG B C   1 
ATOM   2571 O O   . ARG B 2 257 ? 149.096 125.322 145.071 1.00 66.60  ? 279 ARG B O   1 
ATOM   2572 C CB  . ARG B 2 257 ? 147.829 122.195 144.919 1.00 66.60  ? 279 ARG B CB  1 
ATOM   2573 C CG  . ARG B 2 257 ? 147.974 122.513 143.441 1.00 66.60  ? 279 ARG B CG  1 
ATOM   2574 C CD  . ARG B 2 257 ? 147.802 121.272 142.583 1.00 66.60  ? 279 ARG B CD  1 
ATOM   2575 N NE  . ARG B 2 257 ? 146.456 120.719 142.682 1.00 66.60  ? 279 ARG B NE  1 
ATOM   2576 C CZ  . ARG B 2 257 ? 146.021 119.682 141.974 1.00 66.60  ? 279 ARG B CZ  1 
ATOM   2577 N NH1 . ARG B 2 257 ? 146.829 119.082 141.110 1.00 66.60  ? 279 ARG B NH1 1 
ATOM   2578 N NH2 . ARG B 2 257 ? 144.779 119.244 142.128 1.00 66.60  ? 279 ARG B NH2 1 
ATOM   2579 N N   . THR B 2 258 ? 150.175 123.685 146.195 1.00 62.90  ? 280 THR B N   1 
ATOM   2580 C CA  . THR B 2 258 ? 151.489 124.311 146.108 1.00 62.90  ? 280 THR B CA  1 
ATOM   2581 C C   . THR B 2 258 ? 152.509 123.435 145.392 1.00 62.90  ? 280 THR B C   1 
ATOM   2582 O O   . THR B 2 258 ? 153.714 123.689 145.503 1.00 62.90  ? 280 THR B O   1 
ATOM   2583 C CB  . THR B 2 258 ? 152.005 124.674 147.503 1.00 62.90  ? 280 THR B CB  1 
ATOM   2584 O OG1 . THR B 2 258 ? 152.088 123.490 148.306 1.00 62.90  ? 280 THR B OG1 1 
ATOM   2585 C CG2 . THR B 2 258 ? 151.075 125.673 148.172 1.00 62.90  ? 280 THR B CG2 1 
ATOM   2586 N N   . SER B 2 259 ? 152.064 122.413 144.665 1.00 61.79  ? 281 SER B N   1 
ATOM   2587 C CA  . SER B 2 259 ? 152.975 121.534 143.948 1.00 61.79  ? 281 SER B CA  1 
ATOM   2588 C C   . SER B 2 259 ? 152.229 120.885 142.794 1.00 61.79  ? 281 SER B C   1 
ATOM   2589 O O   . SER B 2 259 ? 151.020 120.652 142.872 1.00 61.79  ? 281 SER B O   1 
ATOM   2590 C CB  . SER B 2 259 ? 153.567 120.463 144.870 1.00 61.79  ? 281 SER B CB  1 
ATOM   2591 O OG  . SER B 2 259 ? 152.728 119.323 144.926 1.00 61.79  ? 281 SER B OG  1 
ATOM   2592 N N   . PHE B 2 260 ? 152.965 120.595 141.723 1.00 60.24  ? 282 PHE B N   1 
ATOM   2593 C CA  . PHE B 2 260 ? 152.397 119.949 140.550 1.00 60.24  ? 282 PHE B CA  1 
ATOM   2594 C C   . PHE B 2 260 ? 153.485 119.140 139.861 1.00 60.24  ? 282 PHE B C   1 
ATOM   2595 O O   . PHE B 2 260 ? 154.645 119.559 139.820 1.00 60.24  ? 282 PHE B O   1 
ATOM   2596 C CB  . PHE B 2 260 ? 151.797 120.976 139.583 1.00 60.24  ? 282 PHE B CB  1 
ATOM   2597 C CG  . PHE B 2 260 ? 151.164 120.366 138.367 1.00 60.24  ? 282 PHE B CG  1 
ATOM   2598 C CD1 . PHE B 2 260 ? 151.791 120.433 137.135 1.00 60.24  ? 282 PHE B CD1 1 
ATOM   2599 C CD2 . PHE B 2 260 ? 149.943 119.721 138.456 1.00 60.24  ? 282 PHE B CD2 1 
ATOM   2600 C CE1 . PHE B 2 260 ? 151.210 119.873 136.014 1.00 60.24  ? 282 PHE B CE1 1 
ATOM   2601 C CE2 . PHE B 2 260 ? 149.358 119.157 137.339 1.00 60.24  ? 282 PHE B CE2 1 
ATOM   2602 C CZ  . PHE B 2 260 ? 149.993 119.233 136.117 1.00 60.24  ? 282 PHE B CZ  1 
ATOM   2603 N N   . THR B 2 261 ? 153.105 117.985 139.322 1.00 61.71  ? 283 THR B N   1 
ATOM   2604 C CA  . THR B 2 261 ? 154.038 117.064 138.680 1.00 61.71  ? 283 THR B CA  1 
ATOM   2605 C C   . THR B 2 261 ? 153.768 117.058 137.180 1.00 61.71  ? 283 THR B C   1 
ATOM   2606 O O   . THR B 2 261 ? 152.752 116.517 136.729 1.00 61.71  ? 283 THR B O   1 
ATOM   2607 C CB  . THR B 2 261 ? 153.906 115.658 139.262 1.00 61.71  ? 283 THR B CB  1 
ATOM   2608 O OG1 . THR B 2 261 ? 154.187 115.691 140.667 1.00 61.71  ? 283 THR B OG1 1 
ATOM   2609 C CG2 . THR B 2 261 ? 154.877 114.708 138.579 1.00 61.71  ? 283 THR B CG2 1 
ATOM   2610 N N   . VAL B 2 262 ? 154.677 117.651 136.414 1.00 61.21  ? 284 VAL B N   1 
ATOM   2611 C CA  . VAL B 2 262 ? 154.553 117.684 134.961 1.00 61.21  ? 284 VAL B CA  1 
ATOM   2612 C C   . VAL B 2 262 ? 155.062 116.368 134.391 1.00 61.21  ? 284 VAL B C   1 
ATOM   2613 O O   . VAL B 2 262 ? 156.161 115.915 134.731 1.00 61.21  ? 284 VAL B O   1 
ATOM   2614 C CB  . VAL B 2 262 ? 155.324 118.877 134.376 1.00 61.21  ? 284 VAL B CB  1 
ATOM   2615 C CG1 . VAL B 2 262 ? 155.219 118.884 132.860 1.00 61.21  ? 284 VAL B CG1 1 
ATOM   2616 C CG2 . VAL B 2 262 ? 154.802 120.181 134.958 1.00 61.21  ? 284 VAL B CG2 1 
ATOM   2617 N N   . GLN B 2 263 ? 154.268 115.753 133.523 1.00 67.28  ? 285 GLN B N   1 
ATOM   2618 C CA  . GLN B 2 263 ? 154.598 114.470 132.924 1.00 67.28  ? 285 GLN B CA  1 
ATOM   2619 C C   . GLN B 2 263 ? 154.795 114.624 131.419 1.00 67.28  ? 285 GLN B C   1 
ATOM   2620 O O   . GLN B 2 263 ? 154.618 115.705 130.849 1.00 67.28  ? 285 GLN B O   1 
ATOM   2621 C CB  . GLN B 2 263 ? 153.511 113.438 133.232 1.00 67.28  ? 285 GLN B CB  1 
ATOM   2622 C CG  . GLN B 2 263 ? 153.389 113.088 134.704 1.00 67.28  ? 285 GLN B CG  1 
ATOM   2623 C CD  . GLN B 2 263 ? 152.371 111.996 134.955 1.00 67.28  ? 285 GLN B CD  1 
ATOM   2624 O OE1 . GLN B 2 263 ? 151.663 111.573 134.042 1.00 67.28  ? 285 GLN B OE1 1 
ATOM   2625 N NE2 . GLN B 2 263 ? 152.294 111.532 136.196 1.00 67.28  ? 285 GLN B NE2 1 
ATOM   2626 N N   . ASP B 2 264 ? 155.170 113.514 130.781 1.00 71.73  ? 286 ASP B N   1 
ATOM   2627 C CA  . ASP B 2 264 ? 155.418 113.453 129.341 1.00 71.73  ? 286 ASP B CA  1 
ATOM   2628 C C   . ASP B 2 264 ? 156.486 114.473 128.935 1.00 71.73  ? 286 ASP B C   1 
ATOM   2629 O O   . ASP B 2 264 ? 156.245 115.400 128.159 1.00 71.73  ? 286 ASP B O   1 
ATOM   2630 C CB  . ASP B 2 264 ? 154.114 113.655 128.557 1.00 71.73  ? 286 ASP B CB  1 
ATOM   2631 C CG  . ASP B 2 264 ? 154.263 113.365 127.071 1.00 71.73  ? 286 ASP B CG  1 
ATOM   2632 O OD1 . ASP B 2 264 ? 155.403 113.202 126.587 1.00 71.73  ? 286 ASP B OD1 1 
ATOM   2633 O OD2 . ASP B 2 264 ? 153.224 113.298 126.381 1.00 71.73  ? 286 ASP B OD2 1 
ATOM   2634 N N   . LEU B 2 265 ? 157.683 114.286 129.485 1.00 67.87  ? 287 LEU B N   1 
ATOM   2635 C CA  . LEU B 2 265 ? 158.829 115.127 129.180 1.00 67.87  ? 287 LEU B CA  1 
ATOM   2636 C C   . LEU B 2 265 ? 159.977 114.270 128.666 1.00 67.87  ? 287 LEU B C   1 
ATOM   2637 O O   . LEU B 2 265 ? 160.068 113.073 128.955 1.00 67.87  ? 287 LEU B O   1 
ATOM   2638 C CB  . LEU B 2 265 ? 159.285 115.924 130.408 1.00 67.87  ? 287 LEU B CB  1 
ATOM   2639 C CG  . LEU B 2 265 ? 158.258 116.874 131.022 1.00 67.87  ? 287 LEU B CG  1 
ATOM   2640 C CD1 . LEU B 2 265 ? 158.871 117.652 132.175 1.00 67.87  ? 287 LEU B CD1 1 
ATOM   2641 C CD2 . LEU B 2 265 ? 157.709 117.817 129.966 1.00 67.87  ? 287 LEU B CD2 1 
ATOM   2642 N N   . LYS B 2 266 ? 160.861 114.901 127.903 1.00 71.40  ? 288 LYS B N   1 
ATOM   2643 C CA  . LYS B 2 266 ? 161.979 114.188 127.302 1.00 71.40  ? 288 LYS B CA  1 
ATOM   2644 C C   . LYS B 2 266 ? 163.085 113.968 128.333 1.00 71.40  ? 288 LYS B C   1 
ATOM   2645 O O   . LYS B 2 266 ? 163.401 114.874 129.108 1.00 71.40  ? 288 LYS B O   1 
ATOM   2646 C CB  . LYS B 2 266 ? 162.529 114.964 126.106 1.00 71.40  ? 288 LYS B CB  1 
ATOM   2647 C CG  . LYS B 2 266 ? 161.726 114.787 124.822 1.00 71.40  ? 288 LYS B CG  1 
ATOM   2648 C CD  . LYS B 2 266 ? 161.596 113.323 124.422 1.00 71.40  ? 288 LYS B CD  1 
ATOM   2649 C CE  . LYS B 2 266 ? 162.957 112.675 124.219 1.00 71.40  ? 288 LYS B CE  1 
ATOM   2650 N NZ  . LYS B 2 266 ? 162.885 111.514 123.289 1.00 71.40  ? 288 LYS B NZ  1 
ATOM   2651 N N   . PRO B 2 267 ? 163.679 112.775 128.368 1.00 70.44  ? 289 PRO B N   1 
ATOM   2652 C CA  . PRO B 2 267 ? 164.751 112.515 129.336 1.00 70.44  ? 289 PRO B CA  1 
ATOM   2653 C C   . PRO B 2 267 ? 166.004 113.317 129.020 1.00 70.44  ? 289 PRO B C   1 
ATOM   2654 O O   . PRO B 2 267 ? 166.359 113.518 127.856 1.00 70.44  ? 289 PRO B O   1 
ATOM   2655 C CB  . PRO B 2 267 ? 165.006 111.009 129.190 1.00 70.44  ? 289 PRO B CB  1 
ATOM   2656 C CG  . PRO B 2 267 ? 163.786 110.468 128.509 1.00 70.44  ? 289 PRO B CG  1 
ATOM   2657 C CD  . PRO B 2 267 ? 163.305 111.565 127.619 1.00 70.44  ? 289 PRO B CD  1 
ATOM   2658 N N   . PHE B 2 268 ? 166.671 113.775 130.082 1.00 73.46  ? 290 PHE B N   1 
ATOM   2659 C CA  . PHE B 2 268 ? 167.936 114.508 129.982 1.00 73.46  ? 290 PHE B CA  1 
ATOM   2660 C C   . PHE B 2 268 ? 167.779 115.779 129.149 1.00 73.46  ? 290 PHE B C   1 
ATOM   2661 O O   . PHE B 2 268 ? 168.468 115.986 128.149 1.00 73.46  ? 290 PHE B O   1 
ATOM   2662 C CB  . PHE B 2 268 ? 169.046 113.615 129.424 1.00 73.46  ? 290 PHE B CB  1 
ATOM   2663 C CG  . PHE B 2 268 ? 170.429 114.106 129.736 1.00 73.46  ? 290 PHE B CG  1 
ATOM   2664 C CD1 . PHE B 2 268 ? 171.282 114.505 128.722 1.00 73.46  ? 290 PHE B CD1 1 
ATOM   2665 C CD2 . PHE B 2 268 ? 170.874 114.176 131.045 1.00 73.46  ? 290 PHE B CD2 1 
ATOM   2666 C CE1 . PHE B 2 268 ? 172.555 114.960 129.007 1.00 73.46  ? 290 PHE B CE1 1 
ATOM   2667 C CE2 . PHE B 2 268 ? 172.145 114.629 131.337 1.00 73.46  ? 290 PHE B CE2 1 
ATOM   2668 C CZ  . PHE B 2 268 ? 172.987 115.022 130.317 1.00 73.46  ? 290 PHE B CZ  1 
ATOM   2669 N N   . THR B 2 269 ? 166.856 116.640 129.574 1.00 69.88  ? 291 THR B N   1 
ATOM   2670 C CA  . THR B 2 269 ? 166.612 117.910 128.907 1.00 69.88  ? 291 THR B CA  1 
ATOM   2671 C C   . THR B 2 269 ? 166.259 118.962 129.948 1.00 69.88  ? 291 THR B C   1 
ATOM   2672 O O   . THR B 2 269 ? 165.548 118.673 130.914 1.00 69.88  ? 291 THR B O   1 
ATOM   2673 C CB  . THR B 2 269 ? 165.482 117.797 127.873 1.00 69.88  ? 291 THR B CB  1 
ATOM   2674 O OG1 . THR B 2 269 ? 165.616 116.571 127.144 1.00 69.88  ? 291 THR B OG1 1 
ATOM   2675 C CG2 . THR B 2 269 ? 165.532 118.963 126.896 1.00 69.88  ? 291 THR B CG2 1 
ATOM   2676 N N   . GLU B 2 270 ? 166.760 120.177 129.747 1.00 67.75  ? 292 GLU B N   1 
ATOM   2677 C CA  . GLU B 2 270 ? 166.487 121.283 130.652 1.00 67.75  ? 292 GLU B CA  1 
ATOM   2678 C C   . GLU B 2 270 ? 165.200 121.993 130.250 1.00 67.75  ? 292 GLU B C   1 
ATOM   2679 O O   . GLU B 2 270 ? 164.801 121.983 129.082 1.00 67.75  ? 292 GLU B O   1 
ATOM   2680 C CB  . GLU B 2 270 ? 167.651 122.275 130.660 1.00 67.75  ? 292 GLU B CB  1 
ATOM   2681 C CG  . GLU B 2 270 ? 167.820 123.015 131.976 1.00 67.75  ? 292 GLU B CG  1 
ATOM   2682 C CD  . GLU B 2 270 ? 168.940 124.035 131.936 1.00 67.75  ? 292 GLU B CD  1 
ATOM   2683 O OE1 . GLU B 2 270 ? 168.789 125.058 131.236 1.00 67.75  ? 292 GLU B OE1 1 
ATOM   2684 O OE2 . GLU B 2 270 ? 169.971 123.815 132.604 1.00 67.75  ? 292 GLU B OE2 1 
ATOM   2685 N N   . TYR B 2 271 ? 164.550 122.613 131.233 1.00 61.22  ? 293 TYR B N   1 
ATOM   2686 C CA  . TYR B 2 271 ? 163.283 123.293 131.008 1.00 61.22  ? 293 TYR B CA  1 
ATOM   2687 C C   . TYR B 2 271 ? 163.215 124.551 131.862 1.00 61.22  ? 293 TYR B C   1 
ATOM   2688 O O   . TYR B 2 271 ? 163.943 124.700 132.846 1.00 61.22  ? 293 TYR B O   1 
ATOM   2689 C CB  . TYR B 2 271 ? 162.091 122.378 131.318 1.00 61.22  ? 293 TYR B CB  1 
ATOM   2690 C CG  . TYR B 2 271 ? 161.930 121.230 130.348 1.00 61.22  ? 293 TYR B CG  1 
ATOM   2691 C CD1 . TYR B 2 271 ? 161.165 121.369 129.199 1.00 61.22  ? 293 TYR B CD1 1 
ATOM   2692 C CD2 . TYR B 2 271 ? 162.540 120.006 130.583 1.00 61.22  ? 293 TYR B CD2 1 
ATOM   2693 C CE1 . TYR B 2 271 ? 161.014 120.323 128.310 1.00 61.22  ? 293 TYR B CE1 1 
ATOM   2694 C CE2 . TYR B 2 271 ? 162.395 118.955 129.700 1.00 61.22  ? 293 TYR B CE2 1 
ATOM   2695 C CZ  . TYR B 2 271 ? 161.631 119.119 128.566 1.00 61.22  ? 293 TYR B CZ  1 
ATOM   2696 O OH  . TYR B 2 271 ? 161.484 118.073 127.685 1.00 61.22  ? 293 TYR B OH  1 
ATOM   2697 N N   . VAL B 2 272 ? 162.325 125.460 131.466 1.00 59.74  ? 294 VAL B N   1 
ATOM   2698 C CA  . VAL B 2 272 ? 162.095 126.716 132.168 1.00 59.74  ? 294 VAL B CA  1 
ATOM   2699 C C   . VAL B 2 272 ? 160.610 126.818 132.489 1.00 59.74  ? 294 VAL B C   1 
ATOM   2700 O O   . VAL B 2 272 ? 159.763 126.460 131.663 1.00 59.74  ? 294 VAL B O   1 
ATOM   2701 C CB  . VAL B 2 272 ? 162.559 127.930 131.335 1.00 59.74  ? 294 VAL B CB  1 
ATOM   2702 C CG1 . VAL B 2 272 ? 162.407 129.215 132.129 1.00 59.74  ? 294 VAL B CG1 1 
ATOM   2703 C CG2 . VAL B 2 272 ? 163.998 127.748 130.882 1.00 59.74  ? 294 VAL B CG2 1 
ATOM   2704 N N   . PHE B 2 273 ? 160.293 127.307 133.687 1.00 58.17  ? 295 PHE B N   1 
ATOM   2705 C CA  . PHE B 2 273 ? 158.918 127.371 134.160 1.00 58.17  ? 295 PHE B CA  1 
ATOM   2706 C C   . PHE B 2 273 ? 158.581 128.779 134.629 1.00 58.17  ? 295 PHE B C   1 
ATOM   2707 O O   . PHE B 2 273 ? 159.462 129.555 135.008 1.00 58.17  ? 295 PHE B O   1 
ATOM   2708 C CB  . PHE B 2 273 ? 158.675 126.376 135.303 1.00 58.17  ? 295 PHE B CB  1 
ATOM   2709 C CG  . PHE B 2 273 ? 158.765 124.935 134.887 1.00 58.17  ? 295 PHE B CG  1 
ATOM   2710 C CD1 . PHE B 2 273 ? 157.621 124.208 134.607 1.00 58.17  ? 295 PHE B CD1 1 
ATOM   2711 C CD2 . PHE B 2 273 ? 159.994 124.307 134.780 1.00 58.17  ? 295 PHE B CD2 1 
ATOM   2712 C CE1 . PHE B 2 273 ? 157.702 122.882 134.227 1.00 58.17  ? 295 PHE B CE1 1 
ATOM   2713 C CE2 . PHE B 2 273 ? 160.080 122.982 134.399 1.00 58.17  ? 295 PHE B CE2 1 
ATOM   2714 C CZ  . PHE B 2 273 ? 158.933 122.269 134.122 1.00 58.17  ? 295 PHE B CZ  1 
ATOM   2715 N N   . ARG B 2 274 ? 157.288 129.096 134.599 1.00 56.99  ? 296 ARG B N   1 
ATOM   2716 C CA  . ARG B 2 274 ? 156.769 130.356 135.113 1.00 56.99  ? 296 ARG B CA  1 
ATOM   2717 C C   . ARG B 2 274 ? 155.309 130.149 135.486 1.00 56.99  ? 296 ARG B C   1 
ATOM   2718 O O   . ARG B 2 274 ? 154.620 129.314 134.894 1.00 56.99  ? 296 ARG B O   1 
ATOM   2719 C CB  . ARG B 2 274 ? 156.913 131.492 134.093 1.00 56.99  ? 296 ARG B CB  1 
ATOM   2720 C CG  . ARG B 2 274 ? 156.224 131.231 132.767 1.00 56.99  ? 296 ARG B CG  1 
ATOM   2721 C CD  . ARG B 2 274 ? 156.320 132.437 131.849 1.00 56.99  ? 296 ARG B CD  1 
ATOM   2722 N NE  . ARG B 2 274 ? 155.605 132.224 130.595 1.00 56.99  ? 296 ARG B NE  1 
ATOM   2723 C CZ  . ARG B 2 274 ? 155.457 133.149 129.653 1.00 56.99  ? 296 ARG B CZ  1 
ATOM   2724 N NH1 . ARG B 2 274 ? 155.974 134.357 129.821 1.00 56.99  ? 296 ARG B NH1 1 
ATOM   2725 N NH2 . ARG B 2 274 ? 154.789 132.865 128.543 1.00 56.99  ? 296 ARG B NH2 1 
ATOM   2726 N N   . ILE B 2 275 ? 154.841 130.917 136.473 1.00 55.92  ? 297 ILE B N   1 
ATOM   2727 C CA  . ILE B 2 275 ? 153.522 130.706 137.055 1.00 55.92  ? 297 ILE B CA  1 
ATOM   2728 C C   . ILE B 2 275 ? 152.884 132.044 137.411 1.00 55.92  ? 297 ILE B C   1 
ATOM   2729 O O   . ILE B 2 275 ? 153.562 133.057 137.597 1.00 55.92  ? 297 ILE B O   1 
ATOM   2730 C CB  . ILE B 2 275 ? 153.592 129.792 138.301 1.00 55.92  ? 297 ILE B CB  1 
ATOM   2731 C CG1 . ILE B 2 275 ? 152.279 129.035 138.497 1.00 55.92  ? 297 ILE B CG1 1 
ATOM   2732 C CG2 . ILE B 2 275 ? 153.938 130.597 139.544 1.00 55.92  ? 297 ILE B CG2 1 
ATOM   2733 C CD1 . ILE B 2 275 ? 152.343 127.994 139.590 1.00 55.92  ? 297 ILE B CD1 1 
ATOM   2734 N N   . ARG B 2 276 ? 151.554 132.033 137.489 1.00 53.52  ? 298 ARG B N   1 
ATOM   2735 C CA  . ARG B 2 276 ? 150.773 133.178 137.935 1.00 53.52  ? 298 ARG B CA  1 
ATOM   2736 C C   . ARG B 2 276 ? 149.478 132.665 138.547 1.00 53.52  ? 298 ARG B C   1 
ATOM   2737 O O   . ARG B 2 276 ? 148.934 131.646 138.114 1.00 53.52  ? 298 ARG B O   1 
ATOM   2738 C CB  . ARG B 2 276 ? 150.482 134.155 136.789 1.00 53.52  ? 298 ARG B CB  1 
ATOM   2739 C CG  . ARG B 2 276 ? 149.665 133.565 135.653 1.00 53.52  ? 298 ARG B CG  1 
ATOM   2740 C CD  . ARG B 2 276 ? 149.339 134.618 134.605 1.00 53.52  ? 298 ARG B CD  1 
ATOM   2741 N NE  . ARG B 2 276 ? 148.517 134.080 133.526 1.00 53.52  ? 298 ARG B NE  1 
ATOM   2742 C CZ  . ARG B 2 276 ? 148.065 134.797 132.503 1.00 53.52  ? 298 ARG B CZ  1 
ATOM   2743 N NH1 . ARG B 2 276 ? 148.355 136.088 132.416 1.00 53.52  ? 298 ARG B NH1 1 
ATOM   2744 N NH2 . ARG B 2 276 ? 147.323 134.224 131.565 1.00 53.52  ? 298 ARG B NH2 1 
ATOM   2745 N N   . SER B 2 277 ? 148.987 133.378 139.557 1.00 51.69  ? 299 SER B N   1 
ATOM   2746 C CA  . SER B 2 277 ? 147.866 132.914 140.359 1.00 51.69  ? 299 SER B CA  1 
ATOM   2747 C C   . SER B 2 277 ? 146.672 133.851 140.228 1.00 51.69  ? 299 SER B C   1 
ATOM   2748 O O   . SER B 2 277 ? 146.809 135.030 139.890 1.00 51.69  ? 299 SER B O   1 
ATOM   2749 C CB  . SER B 2 277 ? 148.261 132.785 141.835 1.00 51.69  ? 299 SER B CB  1 
ATOM   2750 O OG  . SER B 2 277 ? 148.749 134.016 142.339 1.00 51.69  ? 299 SER B OG  1 
ATOM   2751 N N   . ILE B 2 278 ? 145.490 133.298 140.508 1.00 50.02  ? 300 ILE B N   1 
ATOM   2752 C CA  . ILE B 2 278 ? 144.238 134.046 140.505 1.00 50.02  ? 300 ILE B CA  1 
ATOM   2753 C C   . ILE B 2 278 ? 143.285 133.360 141.475 1.00 50.02  ? 300 ILE B C   1 
ATOM   2754 O O   . ILE B 2 278 ? 143.505 132.220 141.890 1.00 50.02  ? 300 ILE B O   1 
ATOM   2755 C CB  . ILE B 2 278 ? 143.614 134.140 139.091 1.00 50.02  ? 300 ILE B CB  1 
ATOM   2756 C CG1 . ILE B 2 278 ? 142.699 135.362 138.983 1.00 50.02  ? 300 ILE B CG1 1 
ATOM   2757 C CG2 . ILE B 2 278 ? 142.853 132.871 138.756 1.00 50.02  ? 300 ILE B CG2 1 
ATOM   2758 C CD1 . ILE B 2 278 ? 141.969 135.461 137.664 1.00 50.02  ? 300 ILE B CD1 1 
ATOM   2759 N N   . LYS B 2 279 ? 142.219 134.067 141.845 1.00 51.52  ? 301 LYS B N   1 
ATOM   2760 C CA  . LYS B 2 279 ? 141.253 133.530 142.794 1.00 51.52  ? 301 LYS B CA  1 
ATOM   2761 C C   . LYS B 2 279 ? 140.569 132.287 142.230 1.00 51.52  ? 301 LYS B C   1 
ATOM   2762 O O   . LYS B 2 279 ? 140.451 132.112 141.015 1.00 51.52  ? 301 LYS B O   1 
ATOM   2763 C CB  . LYS B 2 279 ? 140.211 134.592 143.148 1.00 51.52  ? 301 LYS B CB  1 
ATOM   2764 C CG  . LYS B 2 279 ? 139.438 134.310 144.425 1.00 51.52  ? 301 LYS B CG  1 
ATOM   2765 C CD  . LYS B 2 279 ? 138.482 135.442 144.754 1.00 51.52  ? 301 LYS B CD  1 
ATOM   2766 C CE  . LYS B 2 279 ? 137.705 135.151 146.025 1.00 51.52  ? 301 LYS B CE  1 
ATOM   2767 N NZ  . LYS B 2 279 ? 136.876 133.922 145.894 1.00 51.52  ? 301 LYS B NZ  1 
ATOM   2768 N N   . ASP B 2 280 ? 140.117 131.417 143.137 1.00 54.32  ? 302 ASP B N   1 
ATOM   2769 C CA  . ASP B 2 280 ? 139.516 130.150 142.726 1.00 54.32  ? 302 ASP B CA  1 
ATOM   2770 C C   . ASP B 2 280 ? 138.210 130.368 141.972 1.00 54.32  ? 302 ASP B C   1 
ATOM   2771 O O   . ASP B 2 280 ? 137.927 129.664 140.996 1.00 54.32  ? 302 ASP B O   1 
ATOM   2772 C CB  . ASP B 2 280 ? 139.284 129.262 143.949 1.00 54.32  ? 302 ASP B CB  1 
ATOM   2773 C CG  . ASP B 2 280 ? 139.227 127.787 143.600 1.00 54.32  ? 302 ASP B CG  1 
ATOM   2774 O OD1 . ASP B 2 280 ? 138.954 127.457 142.427 1.00 54.32  ? 302 ASP B OD1 1 
ATOM   2775 O OD2 . ASP B 2 280 ? 139.455 126.955 144.502 1.00 54.32  ? 302 ASP B OD2 1 
ATOM   2776 N N   . SER B 2 281 ? 137.403 131.337 142.403 1.00 54.11  ? 303 SER B N   1 
ATOM   2777 C CA  . SER B 2 281 ? 136.103 131.575 141.785 1.00 54.11  ? 303 SER B CA  1 
ATOM   2778 C C   . SER B 2 281 ? 136.202 132.179 140.391 1.00 54.11  ? 303 SER B C   1 
ATOM   2779 O O   . SER B 2 281 ? 135.161 132.462 139.788 1.00 54.11  ? 303 SER B O   1 
ATOM   2780 C CB  . SER B 2 281 ? 135.260 132.486 142.680 1.00 54.11  ? 303 SER B CB  1 
ATOM   2781 O OG  . SER B 2 281 ? 134.998 131.873 143.930 1.00 54.11  ? 303 SER B OG  1 
ATOM   2782 N N   . GLY B 2 282 ? 137.408 132.380 139.863 1.00 53.61  ? 304 GLY B N   1 
ATOM   2783 C CA  . GLY B 2 282 ? 137.579 132.964 138.552 1.00 53.61  ? 304 GLY B CA  1 
ATOM   2784 C C   . GLY B 2 282 ? 137.453 134.470 138.496 1.00 53.61  ? 304 GLY B C   1 
ATOM   2785 O O   . GLY B 2 282 ? 137.659 135.050 137.423 1.00 53.61  ? 304 GLY B O   1 
ATOM   2786 N N   . LYS B 2 283 ? 137.125 135.121 139.608 1.00 53.36  ? 305 LYS B N   1 
ATOM   2787 C CA  . LYS B 2 283 ? 137.005 136.568 139.646 1.00 53.36  ? 305 LYS B CA  1 
ATOM   2788 C C   . LYS B 2 283 ? 138.357 137.195 139.981 1.00 53.36  ? 305 LYS B C   1 
ATOM   2789 O O   . LYS B 2 283 ? 139.344 136.506 140.247 1.00 53.36  ? 305 LYS B O   1 
ATOM   2790 C CB  . LYS B 2 283 ? 135.932 136.985 140.649 1.00 53.36  ? 305 LYS B CB  1 
ATOM   2791 C CG  . LYS B 2 283 ? 134.564 136.385 140.368 1.00 53.36  ? 305 LYS B CG  1 
ATOM   2792 C CD  . LYS B 2 283 ? 133.559 136.769 141.440 1.00 53.36  ? 305 LYS B CD  1 
ATOM   2793 C CE  . LYS B 2 283 ? 132.202 136.138 141.174 1.00 53.36  ? 305 LYS B CE  1 
ATOM   2794 N NZ  . LYS B 2 283 ? 131.211 136.482 142.230 1.00 53.36  ? 305 LYS B NZ  1 
ATOM   2795 N N   . GLY B 2 284 ? 138.404 138.523 139.969 1.00 48.01  ? 306 GLY B N   1 
ATOM   2796 C CA  . GLY B 2 284 ? 139.643 139.230 140.220 1.00 48.01  ? 306 GLY B CA  1 
ATOM   2797 C C   . GLY B 2 284 ? 140.453 139.455 138.961 1.00 48.01  ? 306 GLY B C   1 
ATOM   2798 O O   . GLY B 2 284 ? 139.892 139.568 137.867 1.00 48.01  ? 306 GLY B O   1 
ATOM   2799 N N   . TYR B 2 285 ? 141.776 139.521 139.099 1.00 47.21  ? 307 TYR B N   1 
ATOM   2800 C CA  . TYR B 2 285 ? 142.660 139.755 137.968 1.00 47.21  ? 307 TYR B CA  1 
ATOM   2801 C C   . TYR B 2 285 ? 143.855 138.818 138.057 1.00 47.21  ? 307 TYR B C   1 
ATOM   2802 O O   . TYR B 2 285 ? 144.329 138.495 139.149 1.00 47.21  ? 307 TYR B O   1 
ATOM   2803 C CB  . TYR B 2 285 ? 143.139 141.212 137.914 1.00 47.21  ? 307 TYR B CB  1 
ATOM   2804 C CG  . TYR B 2 285 ? 142.021 142.230 137.951 1.00 47.21  ? 307 TYR B CG  1 
ATOM   2805 C CD1 . TYR B 2 285 ? 141.267 142.502 136.819 1.00 47.21  ? 307 TYR B CD1 1 
ATOM   2806 C CD2 . TYR B 2 285 ? 141.725 142.923 139.116 1.00 47.21  ? 307 TYR B CD2 1 
ATOM   2807 C CE1 . TYR B 2 285 ? 140.246 143.432 136.846 1.00 47.21  ? 307 TYR B CE1 1 
ATOM   2808 C CE2 . TYR B 2 285 ? 140.707 143.856 139.153 1.00 47.21  ? 307 TYR B CE2 1 
ATOM   2809 C CZ  . TYR B 2 285 ? 139.971 144.106 138.016 1.00 47.21  ? 307 TYR B CZ  1 
ATOM   2810 O OH  . TYR B 2 285 ? 138.956 145.033 138.046 1.00 47.21  ? 307 TYR B OH  1 
ATOM   2811 N N   . TRP B 2 286 ? 144.335 138.386 136.894 1.00 48.91  ? 308 TRP B N   1 
ATOM   2812 C CA  . TRP B 2 286 ? 145.498 137.511 136.843 1.00 48.91  ? 308 TRP B CA  1 
ATOM   2813 C C   . TRP B 2 286 ? 146.747 138.261 137.288 1.00 48.91  ? 308 TRP B C   1 
ATOM   2814 O O   . TRP B 2 286 ? 146.970 139.413 136.908 1.00 48.91  ? 308 TRP B O   1 
ATOM   2815 C CB  . TRP B 2 286 ? 145.696 136.966 135.429 1.00 48.91  ? 308 TRP B CB  1 
ATOM   2816 C CG  . TRP B 2 286 ? 144.708 135.914 135.035 1.00 48.91  ? 308 TRP B CG  1 
ATOM   2817 C CD1 . TRP B 2 286 ? 143.527 136.104 134.382 1.00 48.91  ? 308 TRP B CD1 1 
ATOM   2818 C CD2 . TRP B 2 286 ? 144.819 134.505 135.263 1.00 48.91  ? 308 TRP B CD2 1 
ATOM   2819 N NE1 . TRP B 2 286 ? 142.893 134.901 134.190 1.00 48.91  ? 308 TRP B NE1 1 
ATOM   2820 C CE2 . TRP B 2 286 ? 143.666 133.903 134.723 1.00 48.91  ? 308 TRP B CE2 1 
ATOM   2821 C CE3 . TRP B 2 286 ? 145.779 133.693 135.872 1.00 48.91  ? 308 TRP B CE3 1 
ATOM   2822 C CZ2 . TRP B 2 286 ? 143.447 132.529 134.774 1.00 48.91  ? 308 TRP B CZ2 1 
ATOM   2823 C CZ3 . TRP B 2 286 ? 145.561 132.329 135.922 1.00 48.91  ? 308 TRP B CZ3 1 
ATOM   2824 C CH2 . TRP B 2 286 ? 144.404 131.761 135.377 1.00 48.91  ? 308 TRP B CH2 1 
ATOM   2825 N N   . SER B 2 287 ? 147.565 137.598 138.100 1.00 52.41  ? 309 SER B N   1 
ATOM   2826 C CA  . SER B 2 287 ? 148.798 138.196 138.579 1.00 52.41  ? 309 SER B CA  1 
ATOM   2827 C C   . SER B 2 287 ? 149.851 138.212 137.474 1.00 52.41  ? 309 SER B C   1 
ATOM   2828 O O   . SER B 2 287 ? 149.696 137.597 136.415 1.00 52.41  ? 309 SER B O   1 
ATOM   2829 C CB  . SER B 2 287 ? 149.321 137.439 139.798 1.00 52.41  ? 309 SER B CB  1 
ATOM   2830 O OG  . SER B 2 287 ? 150.706 137.672 139.982 1.00 52.41  ? 309 SER B OG  1 
ATOM   2831 N N   . ASP B 2 288 ? 150.939 138.932 137.732 1.00 58.42  ? 310 ASP B N   1 
ATOM   2832 C CA  . ASP B 2 288 ? 152.043 138.975 136.789 1.00 58.42  ? 310 ASP B CA  1 
ATOM   2833 C C   . ASP B 2 288 ? 152.800 137.649 136.801 1.00 58.42  ? 310 ASP B C   1 
ATOM   2834 O O   . ASP B 2 288 ? 152.667 136.830 137.716 1.00 58.42  ? 310 ASP B O   1 
ATOM   2835 C CB  . ASP B 2 288 ? 152.986 140.131 137.119 1.00 58.42  ? 310 ASP B CB  1 
ATOM   2836 C CG  . ASP B 2 288 ? 152.571 141.429 136.456 1.00 58.42  ? 310 ASP B CG  1 
ATOM   2837 O OD1 . ASP B 2 288 ? 151.847 141.373 135.440 1.00 58.42  ? 310 ASP B OD1 1 
ATOM   2838 O OD2 . ASP B 2 288 ? 152.970 142.504 136.950 1.00 58.42  ? 310 ASP B OD2 1 
ATOM   2839 N N   . TRP B 2 289 ? 153.606 137.440 135.764 1.00 57.03  ? 311 TRP B N   1 
ATOM   2840 C CA  . TRP B 2 289 ? 154.375 136.209 135.659 1.00 57.03  ? 311 TRP B CA  1 
ATOM   2841 C C   . TRP B 2 289 ? 155.494 136.189 136.692 1.00 57.03  ? 311 TRP B C   1 
ATOM   2842 O O   . TRP B 2 289 ? 156.140 137.207 136.955 1.00 57.03  ? 311 TRP B O   1 
ATOM   2843 C CB  . TRP B 2 289 ? 154.952 136.060 134.252 1.00 57.03  ? 311 TRP B CB  1 
ATOM   2844 C CG  . TRP B 2 289 ? 153.911 135.819 133.205 1.00 57.03  ? 311 TRP B CG  1 
ATOM   2845 C CD1 . TRP B 2 289 ? 153.518 136.683 132.226 1.00 57.03  ? 311 TRP B CD1 1 
ATOM   2846 C CD2 . TRP B 2 289 ? 153.125 134.634 133.032 1.00 57.03  ? 311 TRP B CD2 1 
ATOM   2847 N NE1 . TRP B 2 289 ? 152.539 136.109 131.453 1.00 57.03  ? 311 TRP B NE1 1 
ATOM   2848 C CE2 . TRP B 2 289 ? 152.279 134.851 131.928 1.00 57.03  ? 311 TRP B CE2 1 
ATOM   2849 C CE3 . TRP B 2 289 ? 153.056 133.410 133.704 1.00 57.03  ? 311 TRP B CE3 1 
ATOM   2850 C CZ2 . TRP B 2 289 ? 151.375 133.891 131.481 1.00 57.03  ? 311 TRP B CZ2 1 
ATOM   2851 C CZ3 . TRP B 2 289 ? 152.159 132.459 133.259 1.00 57.03  ? 311 TRP B CZ3 1 
ATOM   2852 C CH2 . TRP B 2 289 ? 151.331 132.704 132.158 1.00 57.03  ? 311 TRP B CH2 1 
ATOM   2853 N N   . SER B 2 290 ? 155.720 135.017 137.280 1.00 62.36  ? 312 SER B N   1 
ATOM   2854 C CA  . SER B 2 290 ? 156.737 134.861 138.306 1.00 62.36  ? 312 SER B CA  1 
ATOM   2855 C C   . SER B 2 290 ? 158.126 134.799 137.674 1.00 62.36  ? 312 SER B C   1 
ATOM   2856 O O   . SER B 2 290 ? 158.294 134.887 136.455 1.00 62.36  ? 312 SER B O   1 
ATOM   2857 C CB  . SER B 2 290 ? 156.462 133.612 139.139 1.00 62.36  ? 312 SER B CB  1 
ATOM   2858 O OG  . SER B 2 290 ? 157.643 133.156 139.776 1.00 62.36  ? 312 SER B OG  1 
ATOM   2859 N N   . GLU B 2 291 ? 159.139 134.644 138.523 1.00 67.02  ? 313 GLU B N   1 
ATOM   2860 C CA  . GLU B 2 291 ? 160.509 134.539 138.042 1.00 67.02  ? 313 GLU B CA  1 
ATOM   2861 C C   . GLU B 2 291 ? 160.737 133.181 137.390 1.00 67.02  ? 313 GLU B C   1 
ATOM   2862 O O   . GLU B 2 291 ? 160.267 132.151 137.880 1.00 67.02  ? 313 GLU B O   1 
ATOM   2863 C CB  . GLU B 2 291 ? 161.503 134.743 139.188 1.00 67.02  ? 313 GLU B CB  1 
ATOM   2864 C CG  . GLU B 2 291 ? 161.632 136.178 139.700 1.00 67.02  ? 313 GLU B CG  1 
ATOM   2865 C CD  . GLU B 2 291 ? 160.330 136.756 140.221 1.00 67.02  ? 313 GLU B CD  1 
ATOM   2866 O OE1 . GLU B 2 291 ? 160.145 137.986 140.121 1.00 67.02  ? 313 GLU B OE1 1 
ATOM   2867 O OE2 . GLU B 2 291 ? 159.495 135.982 140.735 1.00 67.02  ? 313 GLU B OE2 1 
ATOM   2868 N N   . GLU B 2 292 ? 161.461 133.186 136.275 1.00 67.05  ? 314 GLU B N   1 
ATOM   2869 C CA  . GLU B 2 292 ? 161.741 131.952 135.552 1.00 67.05  ? 314 GLU B CA  1 
ATOM   2870 C C   . GLU B 2 292 ? 162.699 131.081 136.356 1.00 67.05  ? 314 GLU B C   1 
ATOM   2871 O O   . GLU B 2 292 ? 163.798 131.520 136.712 1.00 67.05  ? 314 GLU B O   1 
ATOM   2872 C CB  . GLU B 2 292 ? 162.324 132.267 134.177 1.00 67.05  ? 314 GLU B CB  1 
ATOM   2873 C CG  . GLU B 2 292 ? 161.366 132.989 133.244 1.00 67.05  ? 314 GLU B CG  1 
ATOM   2874 C CD  . GLU B 2 292 ? 161.929 133.153 131.845 1.00 67.05  ? 314 GLU B CD  1 
ATOM   2875 O OE1 . GLU B 2 292 ? 163.083 132.736 131.614 1.00 67.05  ? 314 GLU B OE1 1 
ATOM   2876 O OE2 . GLU B 2 292 ? 161.216 133.697 130.976 1.00 67.05  ? 314 GLU B OE2 1 
ATOM   2877 N N   . ALA B 2 293 ? 162.283 129.852 136.643 1.00 62.99  ? 315 ALA B N   1 
ATOM   2878 C CA  . ALA B 2 293 ? 163.106 128.881 137.348 1.00 62.99  ? 315 ALA B CA  1 
ATOM   2879 C C   . ALA B 2 293 ? 163.483 127.747 136.406 1.00 62.99  ? 315 ALA B C   1 
ATOM   2880 O O   . ALA B 2 293 ? 162.656 127.285 135.614 1.00 62.99  ? 315 ALA B O   1 
ATOM   2881 C CB  . ALA B 2 293 ? 162.378 128.324 138.573 1.00 62.99  ? 315 ALA B CB  1 
ATOM   2882 N N   . SER B 2 294 ? 164.731 127.301 136.495 1.00 61.33  ? 316 SER B N   1 
ATOM   2883 C CA  . SER B 2 294 ? 165.256 126.266 135.619 1.00 61.33  ? 316 SER B CA  1 
ATOM   2884 C C   . SER B 2 294 ? 165.229 124.908 136.310 1.00 61.33  ? 316 SER B C   1 
ATOM   2885 O O   . SER B 2 294 ? 165.198 124.815 137.539 1.00 61.33  ? 316 SER B O   1 
ATOM   2886 C CB  . SER B 2 294 ? 166.685 126.596 135.181 1.00 61.33  ? 316 SER B CB  1 
ATOM   2887 O OG  . SER B 2 294 ? 167.369 125.432 134.753 1.00 61.33  ? 316 SER B OG  1 
ATOM   2888 N N   . GLY B 2 295 ? 165.239 123.852 135.500 1.00 64.88  ? 317 GLY B N   1 
ATOM   2889 C CA  . GLY B 2 295 ? 165.231 122.496 136.011 1.00 64.88  ? 317 GLY B CA  1 
ATOM   2890 C C   . GLY B 2 295 ? 165.668 121.478 134.977 1.00 64.88  ? 317 GLY B C   1 
ATOM   2891 O O   . GLY B 2 295 ? 165.251 121.548 133.817 1.00 64.88  ? 317 GLY B O   1 
ATOM   2892 N N   . THR B 2 296 ? 166.507 120.529 135.381 1.00 66.74  ? 318 THR B N   1 
ATOM   2893 C CA  . THR B 2 296 ? 167.036 119.508 134.488 1.00 66.74  ? 318 THR B CA  1 
ATOM   2894 C C   . THR B 2 296 ? 166.465 118.149 134.868 1.00 66.74  ? 318 THR B C   1 
ATOM   2895 O O   . THR B 2 296 ? 166.494 117.765 136.042 1.00 66.74  ? 318 THR B O   1 
ATOM   2896 C CB  . THR B 2 296 ? 168.566 119.471 134.544 1.00 66.74  ? 318 THR B CB  1 
ATOM   2897 O OG1 . THR B 2 296 ? 169.092 120.734 134.115 1.00 66.74  ? 318 THR B OG1 1 
ATOM   2898 C CG2 . THR B 2 296 ? 169.109 118.372 133.643 1.00 66.74  ? 318 THR B CG2 1 
ATOM   2899 N N   . THR B 2 297 ? 165.949 117.427 133.876 1.00 68.52  ? 319 THR B N   1 
ATOM   2900 C CA  . THR B 2 297 ? 165.399 116.102 134.116 1.00 68.52  ? 319 THR B CA  1 
ATOM   2901 C C   . THR B 2 297 ? 166.510 115.109 134.449 1.00 68.52  ? 319 THR B C   1 
ATOM   2902 O O   . THR B 2 297 ? 167.690 115.330 134.163 1.00 68.52  ? 319 THR B O   1 
ATOM   2903 C CB  . THR B 2 297 ? 164.617 115.610 132.898 1.00 68.52  ? 319 THR B CB  1 
ATOM   2904 O OG1 . THR B 2 297 ? 165.474 115.594 131.751 1.00 68.52  ? 319 THR B OG1 1 
ATOM   2905 C CG2 . THR B 2 297 ? 163.433 116.518 132.621 1.00 68.52  ? 319 THR B CG2 1 
ATOM   2906 N N   . TYR B 2 298 ? 166.114 114.001 135.068 1.00 73.19  ? 320 TYR B N   1 
ATOM   2907 C CA  . TYR B 2 298 ? 167.053 112.947 135.410 1.00 73.19  ? 320 TYR B CA  1 
ATOM   2908 C C   . TYR B 2 298 ? 167.384 112.107 134.180 1.00 73.19  ? 320 TYR B C   1 
ATOM   2909 O O   . TYR B 2 298 ? 166.627 112.053 133.208 1.00 73.19  ? 320 TYR B O   1 
ATOM   2910 C CB  . TYR B 2 298 ? 166.482 112.061 136.518 1.00 73.19  ? 320 TYR B CB  1 
ATOM   2911 C CG  . TYR B 2 298 ? 167.516 111.234 137.248 1.00 73.19  ? 320 TYR B CG  1 
ATOM   2912 C CD1 . TYR B 2 298 ? 167.685 109.886 136.961 1.00 73.19  ? 320 TYR B CD1 1 
ATOM   2913 C CD2 . TYR B 2 298 ? 168.321 111.800 138.228 1.00 73.19  ? 320 TYR B CD2 1 
ATOM   2914 C CE1 . TYR B 2 298 ? 168.627 109.126 137.626 1.00 73.19  ? 320 TYR B CE1 1 
ATOM   2915 C CE2 . TYR B 2 298 ? 169.266 111.049 138.899 1.00 73.19  ? 320 TYR B CE2 1 
ATOM   2916 C CZ  . TYR B 2 298 ? 169.415 109.713 138.594 1.00 73.19  ? 320 TYR B CZ  1 
ATOM   2917 O OH  . TYR B 2 298 ? 170.354 108.960 139.259 1.00 73.19  ? 320 TYR B OH  1 
ATOM   2918 N N   . GLU B 2 299 ? 168.537 111.449 134.232 1.00 70.91  ? 321 GLU B N   1 
ATOM   2919 C CA  . GLU B 2 299 ? 168.992 110.615 133.124 1.00 70.91  ? 321 GLU B CA  1 
ATOM   2920 C C   . GLU B 2 299 ? 168.167 109.338 133.017 1.00 70.91  ? 321 GLU B C   1 
ATOM   2921 O O   . GLU B 2 299 ? 167.433 108.983 133.938 1.00 70.91  ? 321 GLU B O   1 
ATOM   2922 C CB  . GLU B 2 299 ? 170.473 110.270 133.284 1.00 70.91  ? 321 GLU B CB  1 
ATOM   2923 C CG  . GLU B 2 299 ? 171.388 111.480 133.334 1.00 70.91  ? 321 GLU B CG  1 
ATOM   2924 C CD  . GLU B 2 299 ? 172.855 111.104 133.275 1.00 70.91  ? 321 GLU B CD  1 
ATOM   2925 O OE1 . GLU B 2 299 ? 173.156 109.896 133.168 1.00 70.91  ? 321 GLU B OE1 1 
ATOM   2926 O OE2 . GLU B 2 299 ? 173.707 112.015 133.334 1.00 70.91  ? 321 GLU B OE2 1 
ATOM   2927 N N   . GLU C 3 121 ? 142.211 141.726 205.764 1.00 90.35  ? 144 GLU C N   1 
ATOM   2928 C CA  . GLU C 3 121 ? 141.169 140.707 205.772 1.00 90.35  ? 144 GLU C CA  1 
ATOM   2929 C C   . GLU C 3 121 ? 141.773 139.322 205.983 1.00 90.35  ? 144 GLU C C   1 
ATOM   2930 O O   . GLU C 3 121 ? 142.837 139.017 205.445 1.00 90.35  ? 144 GLU C O   1 
ATOM   2931 C CB  . GLU C 3 121 ? 140.368 140.742 204.469 1.00 90.35  ? 144 GLU C CB  1 
ATOM   2932 C CG  . GLU C 3 121 ? 139.601 142.035 204.240 1.00 90.35  ? 144 GLU C CG  1 
ATOM   2933 C CD  . GLU C 3 121 ? 140.461 143.124 203.629 1.00 90.35  ? 144 GLU C CD  1 
ATOM   2934 O OE1 . GLU C 3 121 ? 141.605 142.825 203.227 1.00 90.35  ? 144 GLU C OE1 1 
ATOM   2935 O OE2 . GLU C 3 121 ? 139.994 144.280 203.550 1.00 90.35  ? 144 GLU C OE2 1 
ATOM   2936 N N   . PRO C 3 122 ? 141.093 138.485 206.770 1.00 88.31  ? 145 PRO C N   1 
ATOM   2937 C CA  . PRO C 3 122 ? 141.627 137.141 207.044 1.00 88.31  ? 145 PRO C CA  1 
ATOM   2938 C C   . PRO C 3 122 ? 141.731 136.259 205.813 1.00 88.31  ? 145 PRO C C   1 
ATOM   2939 O O   . PRO C 3 122 ? 142.511 135.298 205.825 1.00 88.31  ? 145 PRO C O   1 
ATOM   2940 C CB  . PRO C 3 122 ? 140.628 136.566 208.059 1.00 88.31  ? 145 PRO C CB  1 
ATOM   2941 C CG  . PRO C 3 122 ? 139.949 137.761 208.652 1.00 88.31  ? 145 PRO C CG  1 
ATOM   2942 C CD  . PRO C 3 122 ? 139.874 138.765 207.545 1.00 88.31  ? 145 PRO C CD  1 
ATOM   2943 N N   . ASP C 3 123 ? 140.975 136.546 204.752 1.00 85.85  ? 146 ASP C N   1 
ATOM   2944 C CA  . ASP C 3 123 ? 140.999 135.740 203.536 1.00 85.85  ? 146 ASP C CA  1 
ATOM   2945 C C   . ASP C 3 123 ? 141.552 136.512 202.344 1.00 85.85  ? 146 ASP C C   1 
ATOM   2946 O O   . ASP C 3 123 ? 141.334 136.112 201.196 1.00 85.85  ? 146 ASP C O   1 
ATOM   2947 C CB  . ASP C 3 123 ? 139.599 135.210 203.216 1.00 85.85  ? 146 ASP C CB  1 
ATOM   2948 C CG  . ASP C 3 123 ? 139.142 134.141 204.189 1.00 85.85  ? 146 ASP C CG  1 
ATOM   2949 O OD1 . ASP C 3 123 ? 139.604 134.151 205.349 1.00 85.85  ? 146 ASP C OD1 1 
ATOM   2950 O OD2 . ASP C 3 123 ? 138.318 133.290 203.794 1.00 85.85  ? 146 ASP C OD2 1 
ATOM   2951 N N   . LYS C 3 124 ? 142.264 137.609 202.588 1.00 77.85  ? 147 LYS C N   1 
ATOM   2952 C CA  . LYS C 3 124 ? 142.831 138.428 201.526 1.00 77.85  ? 147 LYS C CA  1 
ATOM   2953 C C   . LYS C 3 124 ? 144.282 138.753 201.863 1.00 77.85  ? 147 LYS C C   1 
ATOM   2954 O O   . LYS C 3 124 ? 144.791 138.400 202.931 1.00 77.85  ? 147 LYS C O   1 
ATOM   2955 C CB  . LYS C 3 124 ? 142.013 139.709 201.318 1.00 77.85  ? 147 LYS C CB  1 
ATOM   2956 C CG  . LYS C 3 124 ? 141.899 140.143 199.866 1.00 77.85  ? 147 LYS C CG  1 
ATOM   2957 C CD  . LYS C 3 124 ? 141.848 141.656 199.742 1.00 77.85  ? 147 LYS C CD  1 
ATOM   2958 C CE  . LYS C 3 124 ? 141.718 142.085 198.290 1.00 77.85  ? 147 LYS C CE  1 
ATOM   2959 N NZ  . LYS C 3 124 ? 141.744 143.566 198.142 1.00 77.85  ? 147 LYS C NZ  1 
ATOM   2960 N N   . SER C 3 125 ? 144.950 139.436 200.937 1.00 66.75  ? 148 SER C N   1 
ATOM   2961 C CA  . SER C 3 125 ? 146.346 139.807 201.111 1.00 66.75  ? 148 SER C CA  1 
ATOM   2962 C C   . SER C 3 125 ? 146.626 141.071 200.314 1.00 66.75  ? 148 SER C C   1 
ATOM   2963 O O   . SER C 3 125 ? 145.997 141.325 199.284 1.00 66.75  ? 148 SER C O   1 
ATOM   2964 C CB  . SER C 3 125 ? 147.286 138.680 200.669 1.00 66.75  ? 148 SER C CB  1 
ATOM   2965 O OG  . SER C 3 125 ? 147.182 138.453 199.275 1.00 66.75  ? 148 SER C OG  1 
ATOM   2966 N N   . LEU C 3 126 ? 147.580 141.859 200.801 1.00 60.95  ? 149 LEU C N   1 
ATOM   2967 C CA  . LEU C 3 126 ? 147.950 143.121 200.184 1.00 60.95  ? 149 LEU C CA  1 
ATOM   2968 C C   . LEU C 3 126 ? 149.440 143.133 199.871 1.00 60.95  ? 149 LEU C C   1 
ATOM   2969 O O   . LEU C 3 126 ? 150.223 142.364 200.435 1.00 60.95  ? 149 LEU C O   1 
ATOM   2970 C CB  . LEU C 3 126 ? 147.594 144.307 201.090 1.00 60.95  ? 149 LEU C CB  1 
ATOM   2971 C CG  . LEU C 3 126 ? 146.131 144.403 201.524 1.00 60.95  ? 149 LEU C CG  1 
ATOM   2972 C CD1 . LEU C 3 126 ? 145.922 145.595 202.444 1.00 60.95  ? 149 LEU C CD1 1 
ATOM   2973 C CD2 . LEU C 3 126 ? 145.219 144.491 200.312 1.00 60.95  ? 149 LEU C CD2 1 
ATOM   2974 N N   . ILE C 3 127 ? 149.824 144.022 198.960 1.00 51.01  ? 150 ILE C N   1 
ATOM   2975 C CA  . ILE C 3 127 ? 151.212 144.141 198.526 1.00 51.01  ? 150 ILE C CA  1 
ATOM   2976 C C   . ILE C 3 127 ? 151.492 145.601 198.198 1.00 51.01  ? 150 ILE C C   1 
ATOM   2977 O O   . ILE C 3 127 ? 150.699 146.263 197.523 1.00 51.01  ? 150 ILE C O   1 
ATOM   2978 C CB  . ILE C 3 127 ? 151.502 143.217 197.323 1.00 51.01  ? 150 ILE C CB  1 
ATOM   2979 C CG1 . ILE C 3 127 ? 152.882 143.511 196.732 1.00 51.01  ? 150 ILE C CG1 1 
ATOM   2980 C CG2 . ILE C 3 127 ? 150.408 143.342 196.276 1.00 51.01  ? 150 ILE C CG2 1 
ATOM   2981 C CD1 . ILE C 3 127 ? 153.264 142.592 195.594 1.00 51.01  ? 150 ILE C CD1 1 
ATOM   2982 N N   . PHE C 3 128 ? 152.627 146.102 198.689 1.00 50.21  ? 151 PHE C N   1 
ATOM   2983 C CA  . PHE C 3 128 ? 153.047 147.479 198.484 1.00 50.21  ? 151 PHE C CA  1 
ATOM   2984 C C   . PHE C 3 128 ? 154.527 147.495 198.126 1.00 50.21  ? 151 PHE C C   1 
ATOM   2985 O O   . PHE C 3 128 ? 155.297 146.672 198.645 1.00 50.21  ? 151 PHE C O   1 
ATOM   2986 C CB  . PHE C 3 128 ? 152.811 148.337 199.735 1.00 50.21  ? 151 PHE C CB  1 
ATOM   2987 C CG  . PHE C 3 128 ? 151.421 148.234 200.290 1.00 50.21  ? 151 PHE C CG  1 
ATOM   2988 C CD1 . PHE C 3 128 ? 150.400 149.018 199.785 1.00 50.21  ? 151 PHE C CD1 1 
ATOM   2989 C CD2 . PHE C 3 128 ? 151.139 147.359 201.324 1.00 50.21  ? 151 PHE C CD2 1 
ATOM   2990 C CE1 . PHE C 3 128 ? 149.120 148.927 200.296 1.00 50.21  ? 151 PHE C CE1 1 
ATOM   2991 C CE2 . PHE C 3 128 ? 149.861 147.263 201.840 1.00 50.21  ? 151 PHE C CE2 1 
ATOM   2992 C CZ  . PHE C 3 128 ? 148.851 148.049 201.326 1.00 50.21  ? 151 PHE C CZ  1 
ATOM   2993 N N   . PRO C 3 129 ? 154.960 148.413 197.248 1.00 47.15  ? 152 PRO C N   1 
ATOM   2994 C CA  . PRO C 3 129 ? 154.123 149.400 196.562 1.00 47.15  ? 152 PRO C CA  1 
ATOM   2995 C C   . PRO C 3 129 ? 153.503 148.854 195.281 1.00 47.15  ? 152 PRO C C   1 
ATOM   2996 O O   . PRO C 3 129 ? 153.833 147.746 194.862 1.00 47.15  ? 152 PRO C O   1 
ATOM   2997 C CB  . PRO C 3 129 ? 155.109 150.521 196.249 1.00 47.15  ? 152 PRO C CB  1 
ATOM   2998 C CG  . PRO C 3 129 ? 156.392 149.803 196.018 1.00 47.15  ? 152 PRO C CG  1 
ATOM   2999 C CD  . PRO C 3 129 ? 156.388 148.607 196.942 1.00 47.15  ? 152 PRO C CD  1 
ATOM   3000 N N   . LYS C 3 130 ? 152.615 149.632 194.668 1.00 50.37  ? 153 LYS C N   1 
ATOM   3001 C CA  . LYS C 3 130 ? 151.923 149.234 193.451 1.00 50.37  ? 153 LYS C CA  1 
ATOM   3002 C C   . LYS C 3 130 ? 152.322 150.165 192.315 1.00 50.37  ? 153 LYS C C   1 
ATOM   3003 O O   . LYS C 3 130 ? 152.200 151.388 192.440 1.00 50.37  ? 153 LYS C O   1 
ATOM   3004 C CB  . LYS C 3 130 ? 150.405 149.257 193.650 1.00 50.37  ? 153 LYS C CB  1 
ATOM   3005 C CG  . LYS C 3 130 ? 149.925 148.406 194.813 1.00 50.37  ? 153 LYS C CG  1 
ATOM   3006 C CD  . LYS C 3 130 ? 148.433 148.570 195.045 1.00 50.37  ? 153 LYS C CD  1 
ATOM   3007 C CE  . LYS C 3 130 ? 147.978 147.776 196.258 1.00 50.37  ? 153 LYS C CE  1 
ATOM   3008 N NZ  . LYS C 3 130 ? 146.530 147.967 196.539 1.00 50.37  ? 153 LYS C NZ  1 
ATOM   3009 N N   . ASP C 3 131 ? 152.800 149.579 191.216 1.00 46.40  ? 154 ASP C N   1 
ATOM   3010 C CA  . ASP C 3 131 ? 153.184 150.317 190.013 1.00 46.40  ? 154 ASP C CA  1 
ATOM   3011 C C   . ASP C 3 131 ? 154.266 151.354 190.325 1.00 46.40  ? 154 ASP C C   1 
ATOM   3012 O O   . ASP C 3 131 ? 154.081 152.561 190.162 1.00 46.40  ? 154 ASP C O   1 
ATOM   3013 C CB  . ASP C 3 131 ? 151.962 150.969 189.360 1.00 46.40  ? 154 ASP C CB  1 
ATOM   3014 C CG  . ASP C 3 131 ? 150.797 150.011 189.223 1.00 46.40  ? 154 ASP C CG  1 
ATOM   3015 O OD1 . ASP C 3 131 ? 151.038 148.791 189.121 1.00 46.40  ? 154 ASP C OD1 1 
ATOM   3016 O OD2 . ASP C 3 131 ? 149.639 150.479 189.220 1.00 46.40  ? 154 ASP C OD2 1 
ATOM   3017 N N   . LYS C 3 132 ? 155.410 150.854 190.780 1.00 44.49  ? 155 LYS C N   1 
ATOM   3018 C CA  . LYS C 3 132 ? 156.547 151.698 191.120 1.00 44.49  ? 155 LYS C CA  1 
ATOM   3019 C C   . LYS C 3 132 ? 157.372 151.981 189.871 1.00 44.49  ? 155 LYS C C   1 
ATOM   3020 O O   . LYS C 3 132 ? 157.671 151.067 189.097 1.00 44.49  ? 155 LYS C O   1 
ATOM   3021 C CB  . LYS C 3 132 ? 157.413 151.027 192.186 1.00 44.49  ? 155 LYS C CB  1 
ATOM   3022 C CG  . LYS C 3 132 ? 158.609 151.850 192.631 1.00 44.49  ? 155 LYS C CG  1 
ATOM   3023 C CD  . LYS C 3 132 ? 158.174 153.101 193.373 1.00 44.49  ? 155 LYS C CD  1 
ATOM   3024 C CE  . LYS C 3 132 ? 159.374 153.874 193.895 1.00 44.49  ? 155 LYS C CE  1 
ATOM   3025 N NZ  . LYS C 3 132 ? 158.965 155.076 194.673 1.00 44.49  ? 155 LYS C NZ  1 
ATOM   3026 N N   . VAL C 3 133 ? 157.732 153.246 189.678 1.00 47.35  ? 156 VAL C N   1 
ATOM   3027 C CA  . VAL C 3 133 ? 158.574 153.666 188.564 1.00 47.35  ? 156 VAL C CA  1 
ATOM   3028 C C   . VAL C 3 133 ? 159.990 153.856 189.089 1.00 47.35  ? 156 VAL C C   1 
ATOM   3029 O O   . VAL C 3 133 ? 160.228 154.689 189.972 1.00 47.35  ? 156 VAL C O   1 
ATOM   3030 C CB  . VAL C 3 133 ? 158.047 154.954 187.914 1.00 47.35  ? 156 VAL C CB  1 
ATOM   3031 C CG1 . VAL C 3 133 ? 158.941 155.364 186.756 1.00 47.35  ? 156 VAL C CG1 1 
ATOM   3032 C CG2 . VAL C 3 133 ? 156.616 154.761 187.445 1.00 47.35  ? 156 VAL C CG2 1 
ATOM   3033 N N   . LEU C 3 134 ? 160.930 153.087 188.546 1.00 52.71  ? 157 LEU C N   1 
ATOM   3034 C CA  . LEU C 3 134 ? 162.317 153.102 188.986 1.00 52.71  ? 157 LEU C CA  1 
ATOM   3035 C C   . LEU C 3 134 ? 163.225 153.351 187.789 1.00 52.71  ? 157 LEU C C   1 
ATOM   3036 O O   . LEU C 3 134 ? 162.776 153.426 186.641 1.00 52.71  ? 157 LEU C O   1 
ATOM   3037 C CB  . LEU C 3 134 ? 162.693 151.786 189.680 1.00 52.71  ? 157 LEU C CB  1 
ATOM   3038 C CG  . LEU C 3 134 ? 161.998 151.471 191.003 1.00 52.71  ? 157 LEU C CG  1 
ATOM   3039 C CD1 . LEU C 3 134 ? 162.328 150.057 191.444 1.00 52.71  ? 157 LEU C CD1 1 
ATOM   3040 C CD2 . LEU C 3 134 ? 162.402 152.474 192.070 1.00 52.71  ? 157 LEU C CD2 1 
ATOM   3041 N N   . GLU C 3 135 ? 164.517 153.479 188.067 1.00 57.14  ? 158 GLU C N   1 
ATOM   3042 C CA  . GLU C 3 135 ? 165.536 153.634 187.043 1.00 57.14  ? 158 GLU C CA  1 
ATOM   3043 C C   . GLU C 3 135 ? 166.341 152.346 186.929 1.00 57.14  ? 158 GLU C C   1 
ATOM   3044 O O   . GLU C 3 135 ? 166.571 151.650 187.922 1.00 57.14  ? 158 GLU C O   1 
ATOM   3045 C CB  . GLU C 3 135 ? 166.463 154.811 187.361 1.00 57.14  ? 158 GLU C CB  1 
ATOM   3046 C CG  . GLU C 3 135 ? 167.302 155.281 186.185 1.00 57.14  ? 158 GLU C CG  1 
ATOM   3047 C CD  . GLU C 3 135 ? 168.011 156.591 186.465 1.00 57.14  ? 158 GLU C CD  1 
ATOM   3048 O OE1 . GLU C 3 135 ? 167.752 157.194 187.528 1.00 57.14  ? 158 GLU C OE1 1 
ATOM   3049 O OE2 . GLU C 3 135 ? 168.825 157.020 185.621 1.00 57.14  ? 158 GLU C OE2 1 
ATOM   3050 N N   . GLU C 3 136 ? 166.760 152.032 185.704 1.00 55.48  ? 159 GLU C N   1 
ATOM   3051 C CA  . GLU C 3 136 ? 167.485 150.796 185.436 1.00 55.48  ? 159 GLU C CA  1 
ATOM   3052 C C   . GLU C 3 136 ? 168.791 150.740 186.218 1.00 55.48  ? 159 GLU C C   1 
ATOM   3053 O O   . GLU C 3 136 ? 169.702 151.538 185.977 1.00 55.48  ? 159 GLU C O   1 
ATOM   3054 C CB  . GLU C 3 136 ? 167.758 150.657 183.937 1.00 55.48  ? 159 GLU C CB  1 
ATOM   3055 C CG  . GLU C 3 136 ? 168.664 149.495 183.575 1.00 55.48  ? 159 GLU C CG  1 
ATOM   3056 C CD  . GLU C 3 136 ? 168.952 149.426 182.088 1.00 55.48  ? 159 GLU C CD  1 
ATOM   3057 O OE1 . GLU C 3 136 ? 168.132 149.939 181.298 1.00 55.48  ? 159 GLU C OE1 1 
ATOM   3058 O OE2 . GLU C 3 136 ? 169.998 148.858 181.709 1.00 55.48  ? 159 GLU C OE2 1 
ATOM   3059 N N   . GLY C 3 137 ? 168.889 149.803 187.156 1.00 57.90  ? 160 GLY C N   1 
ATOM   3060 C CA  . GLY C 3 137 ? 170.082 149.634 187.958 1.00 57.90  ? 160 GLY C CA  1 
ATOM   3061 C C   . GLY C 3 137 ? 169.946 149.988 189.424 1.00 57.90  ? 160 GLY C C   1 
ATOM   3062 O O   . GLY C 3 137 ? 170.955 149.970 190.139 1.00 57.90  ? 160 GLY C O   1 
ATOM   3063 N N   . SER C 3 138 ? 168.745 150.307 189.897 1.00 59.99  ? 161 SER C N   1 
ATOM   3064 C CA  . SER C 3 138 ? 168.525 150.680 191.283 1.00 59.99  ? 161 SER C CA  1 
ATOM   3065 C C   . SER C 3 138 ? 167.990 149.487 192.073 1.00 59.99  ? 161 SER C C   1 
ATOM   3066 O O   . SER C 3 138 ? 167.771 148.397 191.538 1.00 59.99  ? 161 SER C O   1 
ATOM   3067 C CB  . SER C 3 138 ? 167.569 151.871 191.370 1.00 59.99  ? 161 SER C CB  1 
ATOM   3068 O OG  . SER C 3 138 ? 166.968 151.949 192.650 1.00 59.99  ? 161 SER C OG  1 
ATOM   3069 N N   . ASN C 3 139 ? 167.777 149.701 193.366 1.00 63.91  ? 162 ASN C N   1 
ATOM   3070 C CA  . ASN C 3 139 ? 167.259 148.683 194.267 1.00 63.91  ? 162 ASN C CA  1 
ATOM   3071 C C   . ASN C 3 139 ? 165.832 149.022 194.678 1.00 63.91  ? 162 ASN C C   1 
ATOM   3072 O O   . ASN C 3 139 ? 165.347 150.139 194.477 1.00 63.91  ? 162 ASN C O   1 
ATOM   3073 C CB  . ASN C 3 139 ? 168.150 148.550 195.507 1.00 63.91  ? 162 ASN C CB  1 
ATOM   3074 C CG  . ASN C 3 139 ? 169.528 148.015 195.181 1.00 63.91  ? 162 ASN C CG  1 
ATOM   3075 O OD1 . ASN C 3 139 ? 169.730 147.370 194.153 1.00 63.91  ? 162 ASN C OD1 1 
ATOM   3076 N ND2 . ASN C 3 139 ? 170.485 148.282 196.060 1.00 63.91  ? 162 ASN C ND2 1 
ATOM   3077 N N   . VAL C 3 140 ? 165.159 148.034 195.267 1.00 54.51  ? 163 VAL C N   1 
ATOM   3078 C CA  . VAL C 3 140 ? 163.783 148.203 195.719 1.00 54.51  ? 163 VAL C CA  1 
ATOM   3079 C C   . VAL C 3 140 ? 163.497 147.136 196.764 1.00 54.51  ? 163 VAL C C   1 
ATOM   3080 O O   . VAL C 3 140 ? 164.097 146.058 196.753 1.00 54.51  ? 163 VAL C O   1 
ATOM   3081 C CB  . VAL C 3 140 ? 162.790 148.133 194.530 1.00 54.51  ? 163 VAL C CB  1 
ATOM   3082 C CG1 . VAL C 3 140 ? 162.656 146.707 194.019 1.00 54.51  ? 163 VAL C CG1 1 
ATOM   3083 C CG2 . VAL C 3 140 ? 161.435 148.703 194.923 1.00 54.51  ? 163 VAL C CG2 1 
ATOM   3084 N N   . THR C 3 141 ? 162.585 147.448 197.683 1.00 47.80  ? 164 THR C N   1 
ATOM   3085 C CA  . THR C 3 141 ? 162.154 146.520 198.724 1.00 47.80  ? 164 THR C CA  1 
ATOM   3086 C C   . THR C 3 141 ? 160.633 146.497 198.733 1.00 47.80  ? 164 THR C C   1 
ATOM   3087 O O   . THR C 3 141 ? 159.997 147.488 199.105 1.00 47.80  ? 164 THR C O   1 
ATOM   3088 C CB  . THR C 3 141 ? 162.700 146.925 200.093 1.00 47.80  ? 164 THR C CB  1 
ATOM   3089 O OG1 . THR C 3 141 ? 164.132 146.926 200.058 1.00 47.80  ? 164 THR C OG1 1 
ATOM   3090 C CG2 . THR C 3 141 ? 162.225 145.954 201.162 1.00 47.80  ? 164 THR C CG2 1 
ATOM   3091 N N   . ILE C 3 142 ? 160.051 145.372 198.327 1.00 47.48  ? 165 ILE C N   1 
ATOM   3092 C CA  . ILE C 3 142 ? 158.605 145.226 198.215 1.00 47.48  ? 165 ILE C CA  1 
ATOM   3093 C C   . ILE C 3 142 ? 158.090 144.488 199.441 1.00 47.48  ? 165 ILE C C   1 
ATOM   3094 O O   . ILE C 3 142 ? 158.598 143.415 199.791 1.00 47.48  ? 165 ILE C O   1 
ATOM   3095 C CB  . ILE C 3 142 ? 158.219 144.486 196.924 1.00 47.48  ? 165 ILE C CB  1 
ATOM   3096 C CG1 . ILE C 3 142 ? 158.631 145.306 195.701 1.00 47.48  ? 165 ILE C CG1 1 
ATOM   3097 C CG2 . ILE C 3 142 ? 156.728 144.199 196.899 1.00 47.48  ? 165 ILE C CG2 1 
ATOM   3098 C CD1 . ILE C 3 142 ? 158.252 144.669 194.385 1.00 47.48  ? 165 ILE C CD1 1 
ATOM   3099 N N   . CYS C 3 143 ? 157.083 145.059 200.093 1.00 48.48  ? 166 CYS C N   1 
ATOM   3100 C CA  . CYS C 3 143 ? 156.471 144.470 201.273 1.00 48.48  ? 166 CYS C CA  1 
ATOM   3101 C C   . CYS C 3 143 ? 155.186 143.746 200.895 1.00 48.48  ? 166 CYS C C   1 
ATOM   3102 O O   . CYS C 3 143 ? 154.479 144.141 199.965 1.00 48.48  ? 166 CYS C O   1 
ATOM   3103 C CB  . CYS C 3 143 ? 156.175 145.540 202.326 1.00 48.48  ? 166 CYS C CB  1 
ATOM   3104 S SG  . CYS C 3 143 ? 155.037 145.017 203.626 1.00 48.48  ? 166 CYS C SG  1 
ATOM   3105 N N   . LEU C 3 144 ? 154.892 142.675 201.627 1.00 59.97  ? 167 LEU C N   1 
ATOM   3106 C CA  . LEU C 3 144 ? 153.697 141.873 201.401 1.00 59.97  ? 167 LEU C CA  1 
ATOM   3107 C C   . LEU C 3 144 ? 153.074 141.515 202.741 1.00 59.97  ? 167 LEU C C   1 
ATOM   3108 O O   . LEU C 3 144 ? 153.750 140.971 203.619 1.00 59.97  ? 167 LEU C O   1 
ATOM   3109 C CB  . LEU C 3 144 ? 154.022 140.604 200.607 1.00 59.97  ? 167 LEU C CB  1 
ATOM   3110 C CG  . LEU C 3 144 ? 152.820 139.759 200.188 1.00 59.97  ? 167 LEU C CG  1 
ATOM   3111 C CD1 . LEU C 3 144 ? 152.950 139.333 198.738 1.00 59.97  ? 167 LEU C CD1 1 
ATOM   3112 C CD2 . LEU C 3 144 ? 152.679 138.545 201.090 1.00 59.97  ? 167 LEU C CD2 1 
ATOM   3113 N N   . MET C 3 145 ? 151.785 141.816 202.891 1.00 64.39  ? 168 MET C N   1 
ATOM   3114 C CA  . MET C 3 145 ? 151.053 141.562 204.126 1.00 64.39  ? 168 MET C CA  1 
ATOM   3115 C C   . MET C 3 145 ? 149.827 140.724 203.806 1.00 64.39  ? 168 MET C C   1 
ATOM   3116 O O   . MET C 3 145 ? 148.948 141.169 203.061 1.00 64.39  ? 168 MET C O   1 
ATOM   3117 C CB  . MET C 3 145 ? 150.647 142.873 204.805 1.00 64.39  ? 168 MET C CB  1 
ATOM   3118 C CG  . MET C 3 145 ? 149.750 142.692 206.017 1.00 64.39  ? 168 MET C CG  1 
ATOM   3119 S SD  . MET C 3 145 ? 149.424 144.246 206.868 1.00 64.39  ? 168 MET C SD  1 
ATOM   3120 C CE  . MET C 3 145 ? 148.794 145.242 205.520 1.00 64.39  ? 168 MET C CE  1 
ATOM   3121 N N   . TYR C 3 146 ? 149.768 139.520 204.364 1.00 69.56  ? 169 TYR C N   1 
ATOM   3122 C CA  . TYR C 3 146 ? 148.650 138.612 204.165 1.00 69.56  ? 169 TYR C CA  1 
ATOM   3123 C C   . TYR C 3 146 ? 147.836 138.489 205.448 1.00 69.56  ? 169 TYR C C   1 
ATOM   3124 O O   . TYR C 3 146 ? 148.247 138.933 206.523 1.00 69.56  ? 169 TYR C O   1 
ATOM   3125 C CB  . TYR C 3 146 ? 149.141 137.234 203.703 1.00 69.56  ? 169 TYR C CB  1 
ATOM   3126 C CG  . TYR C 3 146 ? 150.282 136.669 204.521 1.00 69.56  ? 169 TYR C CG  1 
ATOM   3127 C CD1 . TYR C 3 146 ? 151.597 136.798 204.097 1.00 69.56  ? 169 TYR C CD1 1 
ATOM   3128 C CD2 . TYR C 3 146 ? 150.042 135.996 205.712 1.00 69.56  ? 169 TYR C CD2 1 
ATOM   3129 C CE1 . TYR C 3 146 ? 152.641 136.279 204.838 1.00 69.56  ? 169 TYR C CE1 1 
ATOM   3130 C CE2 . TYR C 3 146 ? 151.079 135.475 206.459 1.00 69.56  ? 169 TYR C CE2 1 
ATOM   3131 C CZ  . TYR C 3 146 ? 152.376 135.619 206.018 1.00 69.56  ? 169 TYR C CZ  1 
ATOM   3132 O OH  . TYR C 3 146 ? 153.411 135.100 206.760 1.00 69.56  ? 169 TYR C OH  1 
ATOM   3133 N N   . GLY C 3 147 ? 146.665 137.872 205.320 1.00 78.04  ? 170 GLY C N   1 
ATOM   3134 C CA  . GLY C 3 147 ? 145.758 137.704 206.435 1.00 78.04  ? 170 GLY C CA  1 
ATOM   3135 C C   . GLY C 3 147 ? 146.215 136.629 207.401 1.00 78.04  ? 170 GLY C C   1 
ATOM   3136 O O   . GLY C 3 147 ? 147.377 136.215 207.419 1.00 78.04  ? 170 GLY C O   1 
ATOM   3137 N N   . GLN C 3 148 ? 145.271 136.173 208.223 1.00 84.37  ? 171 GLN C N   1 
ATOM   3138 C CA  . GLN C 3 148 ? 145.555 135.149 209.221 1.00 84.37  ? 171 GLN C CA  1 
ATOM   3139 C C   . GLN C 3 148 ? 145.393 133.738 208.668 1.00 84.37  ? 171 GLN C C   1 
ATOM   3140 O O   . GLN C 3 148 ? 146.166 132.842 209.024 1.00 84.37  ? 171 GLN C O   1 
ATOM   3141 C CB  . GLN C 3 148 ? 144.648 135.337 210.440 1.00 84.37  ? 171 GLN C CB  1 
ATOM   3142 C CG  . GLN C 3 148 ? 144.943 134.384 211.587 1.00 84.37  ? 171 GLN C CG  1 
ATOM   3143 C CD  . GLN C 3 148 ? 144.079 134.650 212.804 1.00 84.37  ? 171 GLN C CD  1 
ATOM   3144 O OE1 . GLN C 3 148 ? 144.267 134.041 213.858 1.00 84.37  ? 171 GLN C OE1 1 
ATOM   3145 N NE2 . GLN C 3 148 ? 143.125 135.563 212.665 1.00 84.37  ? 171 GLN C NE2 1 
ATOM   3146 N N   . ASN C 3 149 ? 144.405 133.520 207.799 1.00 84.92  ? 172 ASN C N   1 
ATOM   3147 C CA  . ASN C 3 149 ? 144.176 132.188 207.252 1.00 84.92  ? 172 ASN C CA  1 
ATOM   3148 C C   . ASN C 3 149 ? 145.193 131.822 206.180 1.00 84.92  ? 172 ASN C C   1 
ATOM   3149 O O   . ASN C 3 149 ? 145.458 130.634 205.965 1.00 84.92  ? 172 ASN C O   1 
ATOM   3150 C CB  . ASN C 3 149 ? 142.759 132.091 206.686 1.00 84.92  ? 172 ASN C CB  1 
ATOM   3151 C CG  . ASN C 3 149 ? 141.701 132.451 207.709 1.00 84.92  ? 172 ASN C CG  1 
ATOM   3152 O OD1 . ASN C 3 149 ? 141.889 132.248 208.908 1.00 84.92  ? 172 ASN C OD1 1 
ATOM   3153 N ND2 . ASN C 3 149 ? 140.582 132.990 207.240 1.00 84.92  ? 172 ASN C ND2 1 
ATOM   3154 N N   . VAL C 3 150 ? 145.769 132.814 205.501 1.00 81.06  ? 173 VAL C N   1 
ATOM   3155 C CA  . VAL C 3 150 ? 146.758 132.538 204.468 1.00 81.06  ? 173 VAL C CA  1 
ATOM   3156 C C   . VAL C 3 150 ? 148.048 132.057 205.117 1.00 81.06  ? 173 VAL C C   1 
ATOM   3157 O O   . VAL C 3 150 ? 148.449 132.541 206.184 1.00 81.06  ? 173 VAL C O   1 
ATOM   3158 C CB  . VAL C 3 150 ? 146.991 133.788 203.604 1.00 81.06  ? 173 VAL C CB  1 
ATOM   3159 C CG1 . VAL C 3 150 ? 147.796 133.437 202.364 1.00 81.06  ? 173 VAL C CG1 1 
ATOM   3160 C CG2 . VAL C 3 150 ? 145.663 134.417 203.220 1.00 81.06  ? 173 VAL C CG2 1 
ATOM   3161 N N   . TYR C 3 151 ? 148.705 131.092 204.476 1.00 85.45  ? 174 TYR C N   1 
ATOM   3162 C CA  . TYR C 3 151 ? 149.901 130.483 205.037 1.00 85.45  ? 174 TYR C CA  1 
ATOM   3163 C C   . TYR C 3 151 ? 150.834 130.065 203.909 1.00 85.45  ? 174 TYR C C   1 
ATOM   3164 O O   . TYR C 3 151 ? 150.386 129.628 202.846 1.00 85.45  ? 174 TYR C O   1 
ATOM   3165 C CB  . TYR C 3 151 ? 149.543 129.277 205.915 1.00 85.45  ? 174 TYR C CB  1 
ATOM   3166 C CG  . TYR C 3 151 ? 150.725 128.634 206.603 1.00 85.45  ? 174 TYR C CG  1 
ATOM   3167 C CD1 . TYR C 3 151 ? 151.330 129.239 207.696 1.00 85.45  ? 174 TYR C CD1 1 
ATOM   3168 C CD2 . TYR C 3 151 ? 151.229 127.417 206.165 1.00 85.45  ? 174 TYR C CD2 1 
ATOM   3169 C CE1 . TYR C 3 151 ? 152.408 128.653 208.329 1.00 85.45  ? 174 TYR C CE1 1 
ATOM   3170 C CE2 . TYR C 3 151 ? 152.306 126.823 206.792 1.00 85.45  ? 174 TYR C CE2 1 
ATOM   3171 C CZ  . TYR C 3 151 ? 152.892 127.445 207.873 1.00 85.45  ? 174 TYR C CZ  1 
ATOM   3172 O OH  . TYR C 3 151 ? 153.966 126.856 208.500 1.00 85.45  ? 174 TYR C OH  1 
ATOM   3173 N N   . ASN C 3 152 ? 152.137 130.208 204.157 1.00 82.40  ? 175 ASN C N   1 
ATOM   3174 C CA  . ASN C 3 152 ? 153.188 129.833 203.208 1.00 82.40  ? 175 ASN C CA  1 
ATOM   3175 C C   . ASN C 3 152 ? 153.011 130.554 201.868 1.00 82.40  ? 175 ASN C C   1 
ATOM   3176 O O   . ASN C 3 152 ? 152.784 129.943 200.822 1.00 82.40  ? 175 ASN C O   1 
ATOM   3177 C CB  . ASN C 3 152 ? 153.238 128.314 203.015 1.00 82.40  ? 175 ASN C CB  1 
ATOM   3178 C CG  . ASN C 3 152 ? 154.195 127.633 203.973 1.00 82.40  ? 175 ASN C CG  1 
ATOM   3179 O OD1 . ASN C 3 152 ? 155.040 128.281 204.590 1.00 82.40  ? 175 ASN C OD1 1 
ATOM   3180 N ND2 . ASN C 3 152 ? 154.075 126.316 204.091 1.00 82.40  ? 175 ASN C ND2 1 
ATOM   3181 N N   . VAL C 3 153 ? 153.119 131.877 201.921 1.00 73.47  ? 176 VAL C N   1 
ATOM   3182 C CA  . VAL C 3 153 ? 153.040 132.699 200.720 1.00 73.47  ? 176 VAL C CA  1 
ATOM   3183 C C   . VAL C 3 153 ? 154.368 132.617 199.981 1.00 73.47  ? 176 VAL C C   1 
ATOM   3184 O O   . VAL C 3 153 ? 155.438 132.738 200.587 1.00 73.47  ? 176 VAL C O   1 
ATOM   3185 C CB  . VAL C 3 153 ? 152.688 134.150 201.077 1.00 73.47  ? 176 VAL C CB  1 
ATOM   3186 C CG1 . VAL C 3 153 ? 152.770 135.037 199.850 1.00 73.47  ? 176 VAL C CG1 1 
ATOM   3187 C CG2 . VAL C 3 153 ? 151.303 134.220 201.689 1.00 73.47  ? 176 VAL C CG2 1 
ATOM   3188 N N   . SER C 3 154 ? 154.305 132.409 198.665 1.00 67.19  ? 177 SER C N   1 
ATOM   3189 C CA  . SER C 3 154 ? 155.497 132.255 197.834 1.00 67.19  ? 177 SER C CA  1 
ATOM   3190 C C   . SER C 3 154 ? 155.357 133.144 196.606 1.00 67.19  ? 177 SER C C   1 
ATOM   3191 O O   . SER C 3 154 ? 154.511 132.886 195.744 1.00 67.19  ? 177 SER C O   1 
ATOM   3192 C CB  . SER C 3 154 ? 155.697 130.796 197.428 1.00 67.19  ? 177 SER C CB  1 
ATOM   3193 O OG  . SER C 3 154 ? 154.729 130.399 196.473 1.00 67.19  ? 177 SER C OG  1 
ATOM   3194 N N   . CYS C 3 155 ? 156.187 134.178 196.523 1.00 62.94  ? 178 CYS C N   1 
ATOM   3195 C CA  . CYS C 3 155 ? 156.182 135.101 195.399 1.00 62.94  ? 178 CYS C CA  1 
ATOM   3196 C C   . CYS C 3 155 ? 157.262 134.722 194.396 1.00 62.94  ? 178 CYS C C   1 
ATOM   3197 O O   . CYS C 3 155 ? 158.300 134.161 194.754 1.00 62.94  ? 178 CYS C O   1 
ATOM   3198 C CB  . CYS C 3 155 ? 156.400 136.539 195.870 1.00 62.94  ? 178 CYS C CB  1 
ATOM   3199 S SG  . CYS C 3 155 ? 155.155 137.150 197.023 1.00 62.94  ? 178 CYS C SG  1 
ATOM   3200 N N   . LYS C 3 156 ? 157.006 135.036 193.127 1.00 54.10  ? 179 LYS C N   1 
ATOM   3201 C CA  . LYS C 3 156 ? 157.947 134.756 192.054 1.00 54.10  ? 179 LYS C CA  1 
ATOM   3202 C C   . LYS C 3 156 ? 157.986 135.928 191.087 1.00 54.10  ? 179 LYS C C   1 
ATOM   3203 O O   . LYS C 3 156 ? 157.029 136.696 190.976 1.00 54.10  ? 179 LYS C O   1 
ATOM   3204 C CB  . LYS C 3 156 ? 157.584 133.480 191.277 1.00 54.10  ? 179 LYS C CB  1 
ATOM   3205 C CG  . LYS C 3 156 ? 156.994 132.353 192.112 1.00 54.10  ? 179 LYS C CG  1 
ATOM   3206 C CD  . LYS C 3 156 ? 156.923 131.055 191.319 1.00 54.10  ? 179 LYS C CD  1 
ATOM   3207 C CE  . LYS C 3 156 ? 156.502 131.302 189.879 1.00 54.10  ? 179 LYS C CE  1 
ATOM   3208 N NZ  . LYS C 3 156 ? 156.366 130.033 189.115 1.00 54.10  ? 179 LYS C NZ  1 
ATOM   3209 N N   . LEU C 3 157 ? 159.113 136.056 190.389 1.00 52.29  ? 180 LEU C N   1 
ATOM   3210 C CA  . LEU C 3 157 ? 159.233 136.979 189.267 1.00 52.29  ? 180 LEU C CA  1 
ATOM   3211 C C   . LEU C 3 157 ? 158.630 136.325 188.030 1.00 52.29  ? 180 LEU C C   1 
ATOM   3212 O O   . LEU C 3 157 ? 157.857 135.369 188.154 1.00 52.29  ? 180 LEU C O   1 
ATOM   3213 C CB  . LEU C 3 157 ? 160.692 137.371 189.033 1.00 52.29  ? 180 LEU C CB  1 
ATOM   3214 C CG  . LEU C 3 157 ? 160.950 138.788 188.517 1.00 52.29  ? 180 LEU C CG  1 
ATOM   3215 C CD1 . LEU C 3 157 ? 160.407 139.818 189.491 1.00 52.29  ? 180 LEU C CD1 1 
ATOM   3216 C CD2 . LEU C 3 157 ? 162.433 139.010 188.270 1.00 52.29  ? 180 LEU C CD2 1 
ATOM   3217 N N   . GLN C 3 158 ? 158.940 136.856 186.842 1.00 52.61  ? 181 GLN C N   1 
ATOM   3218 C CA  . GLN C 3 158 ? 158.429 136.287 185.597 1.00 52.61  ? 181 GLN C CA  1 
ATOM   3219 C C   . GLN C 3 158 ? 158.588 134.769 185.571 1.00 52.61  ? 181 GLN C C   1 
ATOM   3220 O O   . GLN C 3 158 ? 157.599 134.029 185.534 1.00 52.61  ? 181 GLN C O   1 
ATOM   3221 C CB  . GLN C 3 158 ? 159.144 136.925 184.405 1.00 52.61  ? 181 GLN C CB  1 
ATOM   3222 C CG  . GLN C 3 158 ? 158.572 138.265 183.978 1.00 52.61  ? 181 GLN C CG  1 
ATOM   3223 C CD  . GLN C 3 158 ? 157.315 138.121 183.146 1.00 52.61  ? 181 GLN C CD  1 
ATOM   3224 O OE1 . GLN C 3 158 ? 156.245 137.808 183.666 1.00 52.61  ? 181 GLN C OE1 1 
ATOM   3225 N NE2 . GLN C 3 158 ? 157.438 138.350 181.845 1.00 52.61  ? 181 GLN C NE2 1 
ATOM   3226 N N   . ASP C 3 159 ? 159.832 134.284 185.593 1.00 59.47  ? 182 ASP C N   1 
ATOM   3227 C CA  . ASP C 3 159 ? 160.106 132.857 185.792 1.00 59.47  ? 182 ASP C CA  1 
ATOM   3228 C C   . ASP C 3 159 ? 161.400 132.720 186.593 1.00 59.47  ? 182 ASP C C   1 
ATOM   3229 O O   . ASP C 3 159 ? 162.484 132.605 186.015 1.00 59.47  ? 182 ASP C O   1 
ATOM   3230 C CB  . ASP C 3 159 ? 160.190 132.121 184.462 1.00 59.47  ? 182 ASP C CB  1 
ATOM   3231 C CG  . ASP C 3 159 ? 158.884 131.456 184.080 1.00 59.47  ? 182 ASP C CG  1 
ATOM   3232 O OD1 . ASP C 3 159 ? 158.736 131.069 182.902 1.00 59.47  ? 182 ASP C OD1 1 
ATOM   3233 O OD2 . ASP C 3 159 ? 158.011 131.311 184.960 1.00 59.47  ? 182 ASP C OD2 1 
ATOM   3234 N N   . GLU C 3 160 ? 161.270 132.716 187.924 1.00 59.95  ? 183 GLU C N   1 
ATOM   3235 C CA  . GLU C 3 160 ? 162.348 132.407 188.859 1.00 59.95  ? 183 GLU C CA  1 
ATOM   3236 C C   . GLU C 3 160 ? 161.813 132.459 190.284 1.00 59.95  ? 183 GLU C C   1 
ATOM   3237 O O   . GLU C 3 160 ? 160.844 133.179 190.557 1.00 59.95  ? 183 GLU C O   1 
ATOM   3238 C CB  . GLU C 3 160 ? 163.526 133.372 188.703 1.00 59.95  ? 183 GLU C CB  1 
ATOM   3239 C CG  . GLU C 3 160 ? 163.144 134.837 188.713 1.00 59.95  ? 183 GLU C CG  1 
ATOM   3240 C CD  . GLU C 3 160 ? 164.130 135.698 187.948 1.00 59.95  ? 183 GLU C CD  1 
ATOM   3241 O OE1 . GLU C 3 160 ? 163.939 135.882 186.728 1.00 59.95  ? 183 GLU C OE1 1 
ATOM   3242 O OE2 . GLU C 3 160 ? 165.097 136.190 188.568 1.00 59.95  ? 183 GLU C OE2 1 
ATOM   3243 N N   . PRO C 3 161 ? 162.408 131.723 191.216 1.00 62.16  ? 184 PRO C N   1 
ATOM   3244 C CA  . PRO C 3 161 ? 162.029 131.865 192.624 1.00 62.16  ? 184 PRO C CA  1 
ATOM   3245 C C   . PRO C 3 161 ? 162.597 133.142 193.223 1.00 62.16  ? 184 PRO C C   1 
ATOM   3246 O O   . PRO C 3 161 ? 163.532 133.751 192.699 1.00 62.16  ? 184 PRO C O   1 
ATOM   3247 C CB  . PRO C 3 161 ? 162.641 130.625 193.290 1.00 62.16  ? 184 PRO C CB  1 
ATOM   3248 C CG  . PRO C 3 161 ? 163.009 129.703 192.159 1.00 62.16  ? 184 PRO C CG  1 
ATOM   3249 C CD  . PRO C 3 161 ? 163.329 130.596 191.008 1.00 62.16  ? 184 PRO C CD  1 
ATOM   3250 N N   . ILE C 3 162 ? 162.006 133.546 194.345 1.00 61.57  ? 185 ILE C N   1 
ATOM   3251 C CA  . ILE C 3 162 ? 162.442 134.723 195.088 1.00 61.57  ? 185 ILE C CA  1 
ATOM   3252 C C   . ILE C 3 162 ? 162.524 134.349 196.560 1.00 61.57  ? 185 ILE C C   1 
ATOM   3253 O O   . ILE C 3 162 ? 161.536 133.888 197.144 1.00 61.57  ? 185 ILE C O   1 
ATOM   3254 C CB  . ILE C 3 162 ? 161.502 135.922 194.884 1.00 61.57  ? 185 ILE C CB  1 
ATOM   3255 C CG1 . ILE C 3 162 ? 161.625 136.458 193.456 1.00 61.57  ? 185 ILE C CG1 1 
ATOM   3256 C CG2 . ILE C 3 162 ? 161.809 137.018 195.892 1.00 61.57  ? 185 ILE C CG2 1 
ATOM   3257 C CD1 . ILE C 3 162 ? 160.823 137.715 193.203 1.00 61.57  ? 185 ILE C CD1 1 
ATOM   3258 N N   . HIS C 3 163 ? 163.697 134.547 197.158 1.00 67.99  ? 186 HIS C N   1 
ATOM   3259 C CA  . HIS C 3 163 ? 163.933 134.219 198.563 1.00 67.99  ? 186 HIS C CA  1 
ATOM   3260 C C   . HIS C 3 163 ? 163.452 135.387 199.415 1.00 67.99  ? 186 HIS C C   1 
ATOM   3261 O O   . HIS C 3 163 ? 164.147 136.395 199.559 1.00 67.99  ? 186 HIS C O   1 
ATOM   3262 C CB  . HIS C 3 163 ? 165.408 133.919 198.801 1.00 67.99  ? 186 HIS C CB  1 
ATOM   3263 C CG  . HIS C 3 163 ? 165.740 133.608 200.227 1.00 67.99  ? 186 HIS C CG  1 
ATOM   3264 N ND1 . HIS C 3 163 ? 165.166 132.561 200.914 1.00 67.99  ? 186 HIS C ND1 1 
ATOM   3265 C CD2 . HIS C 3 163 ? 166.592 134.204 201.094 1.00 67.99  ? 186 HIS C CD2 1 
ATOM   3266 C CE1 . HIS C 3 163 ? 165.647 132.526 202.144 1.00 67.99  ? 186 HIS C CE1 1 
ATOM   3267 N NE2 . HIS C 3 163 ? 166.514 133.513 202.279 1.00 67.99  ? 186 HIS C NE2 1 
ATOM   3268 N N   . GLY C 3 164 ? 162.256 135.252 199.981 1.00 64.82  ? 187 GLY C N   1 
ATOM   3269 C CA  . GLY C 3 164 ? 161.693 136.295 200.813 1.00 64.82  ? 187 GLY C CA  1 
ATOM   3270 C C   . GLY C 3 164 ? 162.050 136.134 202.280 1.00 64.82  ? 187 GLY C C   1 
ATOM   3271 O O   . GLY C 3 164 ? 162.203 135.026 202.786 1.00 64.82  ? 187 GLY C O   1 
ATOM   3272 N N   . GLU C 3 165 ? 162.181 137.268 202.961 1.00 67.31  ? 188 GLU C N   1 
ATOM   3273 C CA  . GLU C 3 165 ? 162.497 137.310 204.382 1.00 67.31  ? 188 GLU C CA  1 
ATOM   3274 C C   . GLU C 3 165 ? 161.255 137.726 205.158 1.00 67.31  ? 188 GLU C C   1 
ATOM   3275 O O   . GLU C 3 165 ? 160.548 138.654 204.753 1.00 67.31  ? 188 GLU C O   1 
ATOM   3276 C CB  . GLU C 3 165 ? 163.646 138.282 204.663 1.00 67.31  ? 188 GLU C CB  1 
ATOM   3277 C CG  . GLU C 3 165 ? 164.983 137.859 204.077 1.00 67.31  ? 188 GLU C CG  1 
ATOM   3278 C CD  . GLU C 3 165 ? 165.195 138.377 202.667 1.00 67.31  ? 188 GLU C CD  1 
ATOM   3279 O OE1 . GLU C 3 165 ? 164.198 138.734 202.004 1.00 67.31  ? 188 GLU C OE1 1 
ATOM   3280 O OE2 . GLU C 3 165 ? 166.360 138.429 202.221 1.00 67.31  ? 188 GLU C OE2 1 
ATOM   3281 N N   . GLN C 3 166 ? 160.993 137.040 206.268 1.00 71.04  ? 189 GLN C N   1 
ATOM   3282 C CA  . GLN C 3 166 ? 159.818 137.312 207.093 1.00 71.04  ? 189 GLN C CA  1 
ATOM   3283 C C   . GLN C 3 166 ? 160.183 138.369 208.127 1.00 71.04  ? 189 GLN C C   1 
ATOM   3284 O O   . GLN C 3 166 ? 160.892 138.090 209.097 1.00 71.04  ? 189 GLN C O   1 
ATOM   3285 C CB  . GLN C 3 166 ? 159.315 136.034 207.754 1.00 71.04  ? 189 GLN C CB  1 
ATOM   3286 C CG  . GLN C 3 166 ? 158.749 135.018 206.779 1.00 71.04  ? 189 GLN C CG  1 
ATOM   3287 C CD  . GLN C 3 166 ? 158.183 133.797 207.474 1.00 71.04  ? 189 GLN C CD  1 
ATOM   3288 O OE1 . GLN C 3 166 ? 158.269 133.669 208.695 1.00 71.04  ? 189 GLN C OE1 1 
ATOM   3289 N NE2 . GLN C 3 166 ? 157.601 132.891 206.698 1.00 71.04  ? 189 GLN C NE2 1 
ATOM   3290 N N   . LEU C 3 167 ? 159.694 139.594 207.918 1.00 67.61  ? 190 LEU C N   1 
ATOM   3291 C CA  . LEU C 3 167 ? 159.940 140.662 208.881 1.00 67.61  ? 190 LEU C CA  1 
ATOM   3292 C C   . LEU C 3 167 ? 159.194 140.411 210.185 1.00 67.61  ? 190 LEU C C   1 
ATOM   3293 O O   . LEU C 3 167 ? 159.727 140.667 211.271 1.00 67.61  ? 190 LEU C O   1 
ATOM   3294 C CB  . LEU C 3 167 ? 159.537 142.009 208.283 1.00 67.61  ? 190 LEU C CB  1 
ATOM   3295 C CG  . LEU C 3 167 ? 159.548 143.217 209.222 1.00 67.61  ? 190 LEU C CG  1 
ATOM   3296 C CD1 . LEU C 3 167 ? 160.949 143.479 209.751 1.00 67.61  ? 190 LEU C CD1 1 
ATOM   3297 C CD2 . LEU C 3 167 ? 158.999 144.447 208.518 1.00 67.61  ? 190 LEU C CD2 1 
ATOM   3298 N N   . ASP C 3 168 ? 157.968 139.905 210.099 1.00 72.28  ? 191 ASP C N   1 
ATOM   3299 C CA  . ASP C 3 168 ? 157.152 139.627 211.272 1.00 72.28  ? 191 ASP C CA  1 
ATOM   3300 C C   . ASP C 3 168 ? 156.437 138.299 211.048 1.00 72.28  ? 191 ASP C C   1 
ATOM   3301 O O   . ASP C 3 168 ? 156.761 137.544 210.126 1.00 72.28  ? 191 ASP C O   1 
ATOM   3302 C CB  . ASP C 3 168 ? 156.176 140.781 211.539 1.00 72.28  ? 191 ASP C CB  1 
ATOM   3303 C CG  . ASP C 3 168 ? 155.851 140.940 213.011 1.00 72.28  ? 191 ASP C CG  1 
ATOM   3304 O OD1 . ASP C 3 168 ? 156.443 140.210 213.833 1.00 72.28  ? 191 ASP C OD1 1 
ATOM   3305 O OD2 . ASP C 3 168 ? 155.003 141.794 213.344 1.00 72.28  ? 191 ASP C OD2 1 
ATOM   3306 N N   . SER C 3 169 ? 155.454 138.010 211.901 1.00 72.63  ? 192 SER C N   1 
ATOM   3307 C CA  . SER C 3 169 ? 154.724 136.753 211.790 1.00 72.63  ? 192 SER C CA  1 
ATOM   3308 C C   . SER C 3 169 ? 153.744 136.755 210.624 1.00 72.63  ? 192 SER C C   1 
ATOM   3309 O O   . SER C 3 169 ? 153.420 135.687 210.092 1.00 72.63  ? 192 SER C O   1 
ATOM   3310 C CB  . SER C 3 169 ? 153.983 136.458 213.095 1.00 72.63  ? 192 SER C CB  1 
ATOM   3311 O OG  . SER C 3 169 ? 152.708 137.075 213.108 1.00 72.63  ? 192 SER C OG  1 
ATOM   3312 N N   . HIS C 3 170 ? 153.261 137.929 210.213 1.00 72.41  ? 193 HIS C N   1 
ATOM   3313 C CA  . HIS C 3 170 ? 152.294 138.032 209.126 1.00 72.41  ? 193 HIS C CA  1 
ATOM   3314 C C   . HIS C 3 170 ? 152.775 138.922 207.986 1.00 72.41  ? 193 HIS C C   1 
ATOM   3315 O O   . HIS C 3 170 ? 151.979 139.256 207.100 1.00 72.41  ? 193 HIS C O   1 
ATOM   3316 C CB  . HIS C 3 170 ? 150.952 138.546 209.656 1.00 72.41  ? 193 HIS C CB  1 
ATOM   3317 C CG  . HIS C 3 170 ? 150.170 137.522 210.417 1.00 72.41  ? 193 HIS C CG  1 
ATOM   3318 N ND1 . HIS C 3 170 ? 149.468 136.511 209.797 1.00 72.41  ? 193 HIS C ND1 1 
ATOM   3319 C CD2 . HIS C 3 170 ? 149.975 137.354 211.747 1.00 72.41  ? 193 HIS C CD2 1 
ATOM   3320 C CE1 . HIS C 3 170 ? 148.877 135.762 210.712 1.00 72.41  ? 193 HIS C CE1 1 
ATOM   3321 N NE2 . HIS C 3 170 ? 149.169 136.253 211.903 1.00 72.41  ? 193 HIS C NE2 1 
ATOM   3322 N N   . VAL C 3 171 ? 154.048 139.318 207.981 1.00 65.08  ? 194 VAL C N   1 
ATOM   3323 C CA  . VAL C 3 171 ? 154.598 140.169 206.936 1.00 65.08  ? 194 VAL C CA  1 
ATOM   3324 C C   . VAL C 3 171 ? 155.803 139.468 206.322 1.00 65.08  ? 194 VAL C C   1 
ATOM   3325 O O   . VAL C 3 171 ? 156.449 138.625 206.947 1.00 65.08  ? 194 VAL C O   1 
ATOM   3326 C CB  . VAL C 3 171 ? 154.997 141.565 207.468 1.00 65.08  ? 194 VAL C CB  1 
ATOM   3327 C CG1 . VAL C 3 171 ? 155.072 142.572 206.331 1.00 65.08  ? 194 VAL C CG1 1 
ATOM   3328 C CG2 . VAL C 3 171 ? 154.017 142.032 208.532 1.00 65.08  ? 194 VAL C CG2 1 
ATOM   3329 N N   . SER C 3 172 ? 156.100 139.829 205.075 1.00 63.18  ? 195 SER C N   1 
ATOM   3330 C CA  . SER C 3 172 ? 157.228 139.258 204.355 1.00 63.18  ? 195 SER C CA  1 
ATOM   3331 C C   . SER C 3 172 ? 157.808 140.313 203.426 1.00 63.18  ? 195 SER C C   1 
ATOM   3332 O O   . SER C 3 172 ? 157.067 141.014 202.732 1.00 63.18  ? 195 SER C O   1 
ATOM   3333 C CB  . SER C 3 172 ? 156.815 138.017 203.557 1.00 63.18  ? 195 SER C CB  1 
ATOM   3334 O OG  . SER C 3 172 ? 156.504 136.937 204.420 1.00 63.18  ? 195 SER C OG  1 
ATOM   3335 N N   . LEU C 3 173 ? 159.133 140.417 203.416 1.00 57.34  ? 196 LEU C N   1 
ATOM   3336 C CA  . LEU C 3 173 ? 159.842 141.408 202.621 1.00 57.34  ? 196 LEU C CA  1 
ATOM   3337 C C   . LEU C 3 173 ? 160.511 140.743 201.427 1.00 57.34  ? 196 LEU C C   1 
ATOM   3338 O O   . LEU C 3 173 ? 161.076 139.652 201.546 1.00 57.34  ? 196 LEU C O   1 
ATOM   3339 C CB  . LEU C 3 173 ? 160.895 142.134 203.463 1.00 57.34  ? 196 LEU C CB  1 
ATOM   3340 C CG  . LEU C 3 173 ? 160.395 142.848 204.718 1.00 57.34  ? 196 LEU C CG  1 
ATOM   3341 C CD1 . LEU C 3 173 ? 161.554 143.496 205.458 1.00 57.34  ? 196 LEU C CD1 1 
ATOM   3342 C CD2 . LEU C 3 173 ? 159.338 143.879 204.363 1.00 57.34  ? 196 LEU C CD2 1 
ATOM   3343 N N   . LEU C 3 174 ? 160.444 141.407 200.276 1.00 51.66  ? 197 LEU C N   1 
ATOM   3344 C CA  . LEU C 3 174 ? 161.102 140.956 199.058 1.00 51.66  ? 197 LEU C CA  1 
ATOM   3345 C C   . LEU C 3 174 ? 162.135 141.992 198.647 1.00 51.66  ? 197 LEU C C   1 
ATOM   3346 O O   . LEU C 3 174 ? 161.810 143.176 198.508 1.00 51.66  ? 197 LEU C O   1 
ATOM   3347 C CB  . LEU C 3 174 ? 160.092 140.736 197.929 1.00 51.66  ? 197 LEU C CB  1 
ATOM   3348 C CG  . LEU C 3 174 ? 158.951 139.758 198.209 1.00 51.66  ? 197 LEU C CG  1 
ATOM   3349 C CD1 . LEU C 3 174 ? 158.047 139.639 196.994 1.00 51.66  ? 197 LEU C CD1 1 
ATOM   3350 C CD2 . LEU C 3 174 ? 159.496 138.399 198.611 1.00 51.66  ? 197 LEU C CD2 1 
ATOM   3351 N N   . LYS C 3 175 ? 163.374 141.550 198.455 1.00 52.73  ? 198 LYS C N   1 
ATOM   3352 C CA  . LYS C 3 175 ? 164.478 142.431 198.102 1.00 52.73  ? 198 LYS C CA  1 
ATOM   3353 C C   . LYS C 3 175 ? 164.954 142.118 196.691 1.00 52.73  ? 198 LYS C C   1 
ATOM   3354 O O   . LYS C 3 175 ? 165.224 140.957 196.365 1.00 52.73  ? 198 LYS C O   1 
ATOM   3355 C CB  . LYS C 3 175 ? 165.631 142.288 199.096 1.00 52.73  ? 198 LYS C CB  1 
ATOM   3356 C CG  . LYS C 3 175 ? 165.272 142.695 200.515 1.00 52.73  ? 198 LYS C CG  1 
ATOM   3357 C CD  . LYS C 3 175 ? 166.473 142.602 201.440 1.00 52.73  ? 198 LYS C CD  1 
ATOM   3358 C CE  . LYS C 3 175 ? 166.115 143.041 202.849 1.00 52.73  ? 198 LYS C CE  1 
ATOM   3359 N NZ  . LYS C 3 175 ? 167.283 142.959 203.769 1.00 52.73  ? 198 LYS C NZ  1 
ATOM   3360 N N   . LEU C 3 176 ? 165.053 143.153 195.861 1.00 55.26  ? 199 LEU C N   1 
ATOM   3361 C CA  . LEU C 3 176 ? 165.530 143.033 194.491 1.00 55.26  ? 199 LEU C CA  1 
ATOM   3362 C C   . LEU C 3 176 ? 166.726 143.955 194.306 1.00 55.26  ? 199 LEU C C   1 
ATOM   3363 O O   . LEU C 3 176 ? 166.644 145.149 194.610 1.00 55.26  ? 199 LEU C O   1 
ATOM   3364 C CB  . LEU C 3 176 ? 164.428 143.385 193.489 1.00 55.26  ? 199 LEU C CB  1 
ATOM   3365 C CG  . LEU C 3 176 ? 163.080 142.691 193.688 1.00 55.26  ? 199 LEU C CG  1 
ATOM   3366 C CD1 . LEU C 3 176 ? 162.080 143.152 192.642 1.00 55.26  ? 199 LEU C CD1 1 
ATOM   3367 C CD2 . LEU C 3 176 ? 163.245 141.182 193.647 1.00 55.26  ? 199 LEU C CD2 1 
ATOM   3368 N N   . ASN C 3 177 ? 167.829 143.402 193.814 1.00 60.71  ? 200 ASN C N   1 
ATOM   3369 C CA  . ASN C 3 177 ? 169.062 144.151 193.623 1.00 60.71  ? 200 ASN C CA  1 
ATOM   3370 C C   . ASN C 3 177 ? 169.404 144.233 192.142 1.00 60.71  ? 200 ASN C C   1 
ATOM   3371 O O   . ASN C 3 177 ? 169.381 143.221 191.433 1.00 60.71  ? 200 ASN C O   1 
ATOM   3372 C CB  . ASN C 3 177 ? 170.219 143.505 194.390 1.00 60.71  ? 200 ASN C CB  1 
ATOM   3373 C CG  . ASN C 3 177 ? 169.943 143.399 195.876 1.00 60.71  ? 200 ASN C CG  1 
ATOM   3374 O OD1 . ASN C 3 177 ? 170.213 144.327 196.638 1.00 60.71  ? 200 ASN C OD1 1 
ATOM   3375 N ND2 . ASN C 3 177 ? 169.402 142.262 196.297 1.00 60.71  ? 200 ASN C ND2 1 
ATOM   3376 N N   . ASN C 3 178 ? 169.732 145.439 191.691 1.00 60.93  ? 201 ASN C N   1 
ATOM   3377 C CA  . ASN C 3 178 ? 170.115 145.712 190.306 1.00 60.93  ? 201 ASN C CA  1 
ATOM   3378 C C   . ASN C 3 178 ? 169.079 145.163 189.326 1.00 60.93  ? 201 ASN C C   1 
ATOM   3379 O O   . ASN C 3 178 ? 169.335 144.246 188.546 1.00 60.93  ? 201 ASN C O   1 
ATOM   3380 C CB  . ASN C 3 178 ? 171.504 145.153 190.007 1.00 60.93  ? 201 ASN C CB  1 
ATOM   3381 C CG  . ASN C 3 178 ? 172.594 145.864 190.782 1.00 60.93  ? 201 ASN C CG  1 
ATOM   3382 O OD1 . ASN C 3 178 ? 172.949 147.002 190.475 1.00 60.93  ? 201 ASN C OD1 1 
ATOM   3383 N ND2 . ASN C 3 178 ? 173.128 145.197 191.798 1.00 60.93  ? 201 ASN C ND2 1 
ATOM   3384 N N   . VAL C 3 179 ? 167.879 145.746 189.393 1.00 57.11  ? 202 VAL C N   1 
ATOM   3385 C CA  . VAL C 3 179 ? 166.818 145.364 188.471 1.00 57.11  ? 202 VAL C CA  1 
ATOM   3386 C C   . VAL C 3 179 ? 167.234 145.695 187.045 1.00 57.11  ? 202 VAL C C   1 
ATOM   3387 O O   . VAL C 3 179 ? 167.890 146.712 186.784 1.00 57.11  ? 202 VAL C O   1 
ATOM   3388 C CB  . VAL C 3 179 ? 165.500 146.063 188.847 1.00 57.11  ? 202 VAL C CB  1 
ATOM   3389 C CG1 . VAL C 3 179 ? 164.971 145.520 190.165 1.00 57.11  ? 202 VAL C CG1 1 
ATOM   3390 C CG2 . VAL C 3 179 ? 165.699 147.567 188.933 1.00 57.11  ? 202 VAL C CG2 1 
ATOM   3391 N N   . VAL C 3 180 ? 166.860 144.826 186.113 1.00 53.85  ? 203 VAL C N   1 
ATOM   3392 C CA  . VAL C 3 180 ? 167.230 144.978 184.715 1.00 53.85  ? 203 VAL C CA  1 
ATOM   3393 C C   . VAL C 3 180 ? 165.985 145.330 183.909 1.00 53.85  ? 203 VAL C C   1 
ATOM   3394 O O   . VAL C 3 180 ? 164.869 144.897 184.212 1.00 53.85  ? 203 VAL C O   1 
ATOM   3395 C CB  . VAL C 3 180 ? 167.914 143.704 184.169 1.00 53.85  ? 203 VAL C CB  1 
ATOM   3396 C CG1 . VAL C 3 180 ? 167.004 142.493 184.335 1.00 53.85  ? 203 VAL C CG1 1 
ATOM   3397 C CG2 . VAL C 3 180 ? 168.339 143.880 182.714 1.00 53.85  ? 203 VAL C CG2 1 
ATOM   3398 N N   . PHE C 3 181 ? 166.186 146.138 182.870 1.00 48.20  ? 204 PHE C N   1 
ATOM   3399 C CA  . PHE C 3 181 ? 165.100 146.547 181.990 1.00 48.20  ? 204 PHE C CA  1 
ATOM   3400 C C   . PHE C 3 181 ? 164.684 145.372 181.115 1.00 48.20  ? 204 PHE C C   1 
ATOM   3401 O O   . PHE C 3 181 ? 165.513 144.801 180.399 1.00 48.20  ? 204 PHE C O   1 
ATOM   3402 C CB  . PHE C 3 181 ? 165.533 147.735 181.133 1.00 48.20  ? 204 PHE C CB  1 
ATOM   3403 C CG  . PHE C 3 181 ? 164.485 148.203 180.164 1.00 48.20  ? 204 PHE C CG  1 
ATOM   3404 C CD1 . PHE C 3 181 ? 164.495 147.772 178.849 1.00 48.20  ? 204 PHE C CD1 1 
ATOM   3405 C CD2 . PHE C 3 181 ? 163.494 149.082 180.566 1.00 48.20  ? 204 PHE C CD2 1 
ATOM   3406 C CE1 . PHE C 3 181 ? 163.535 148.203 177.955 1.00 48.20  ? 204 PHE C CE1 1 
ATOM   3407 C CE2 . PHE C 3 181 ? 162.531 149.517 179.677 1.00 48.20  ? 204 PHE C CE2 1 
ATOM   3408 C CZ  . PHE C 3 181 ? 162.552 149.077 178.370 1.00 48.20  ? 204 PHE C CZ  1 
ATOM   3409 N N   . LEU C 3 182 ? 163.403 145.013 181.169 1.00 46.20  ? 205 LEU C N   1 
ATOM   3410 C CA  . LEU C 3 182 ? 162.860 143.908 180.389 1.00 46.20  ? 205 LEU C CA  1 
ATOM   3411 C C   . LEU C 3 182 ? 162.025 144.379 179.209 1.00 46.20  ? 205 LEU C C   1 
ATOM   3412 O O   . LEU C 3 182 ? 162.280 143.976 178.070 1.00 46.20  ? 205 LEU C O   1 
ATOM   3413 C CB  . LEU C 3 182 ? 162.020 142.992 181.292 1.00 46.20  ? 205 LEU C CB  1 
ATOM   3414 C CG  . LEU C 3 182 ? 161.706 141.588 180.768 1.00 46.20  ? 205 LEU C CG  1 
ATOM   3415 C CD1 . LEU C 3 182 ? 161.770 140.575 181.898 1.00 46.20  ? 205 LEU C CD1 1 
ATOM   3416 C CD2 . LEU C 3 182 ? 160.343 141.546 180.096 1.00 46.20  ? 205 LEU C CD2 1 
ATOM   3417 N N   . SER C 3 183 ? 161.028 145.226 179.453 1.00 46.56  ? 206 SER C N   1 
ATOM   3418 C CA  . SER C 3 183 ? 160.193 145.759 178.387 1.00 46.56  ? 206 SER C CA  1 
ATOM   3419 C C   . SER C 3 183 ? 159.540 147.040 178.883 1.00 46.56  ? 206 SER C C   1 
ATOM   3420 O O   . SER C 3 183 ? 159.469 147.295 180.088 1.00 46.56  ? 206 SER C O   1 
ATOM   3421 C CB  . SER C 3 183 ? 159.133 144.748 177.938 1.00 46.56  ? 206 SER C CB  1 
ATOM   3422 O OG  . SER C 3 183 ? 158.212 145.340 177.039 1.00 46.56  ? 206 SER C OG  1 
ATOM   3423 N N   . ASP C 3 184 ? 159.057 147.843 177.933 1.00 47.47  ? 207 ASP C N   1 
ATOM   3424 C CA  . ASP C 3 184 ? 158.436 149.116 178.275 1.00 47.47  ? 207 ASP C CA  1 
ATOM   3425 C C   . ASP C 3 184 ? 157.083 148.953 178.955 1.00 47.47  ? 207 ASP C C   1 
ATOM   3426 O O   . ASP C 3 184 ? 156.494 149.958 179.365 1.00 47.47  ? 207 ASP C O   1 
ATOM   3427 C CB  . ASP C 3 184 ? 158.282 149.982 177.022 1.00 47.47  ? 207 ASP C CB  1 
ATOM   3428 C CG  . ASP C 3 184 ? 157.392 149.344 175.976 1.00 47.47  ? 207 ASP C CG  1 
ATOM   3429 O OD1 . ASP C 3 184 ? 156.154 149.449 176.099 1.00 47.47  ? 207 ASP C OD1 1 
ATOM   3430 O OD2 . ASP C 3 184 ? 157.931 148.737 175.027 1.00 47.47  ? 207 ASP C OD2 1 
ATOM   3431 N N   . THR C 3 185 ? 156.581 147.728 179.086 1.00 43.88  ? 208 THR C N   1 
ATOM   3432 C CA  . THR C 3 185 ? 155.298 147.467 179.723 1.00 43.88  ? 208 THR C CA  1 
ATOM   3433 C C   . THR C 3 185 ? 155.446 147.063 181.187 1.00 43.88  ? 208 THR C C   1 
ATOM   3434 O O   . THR C 3 185 ? 154.447 147.019 181.912 1.00 43.88  ? 208 THR C O   1 
ATOM   3435 C CB  . THR C 3 185 ? 154.543 146.382 178.945 1.00 43.88  ? 208 THR C CB  1 
ATOM   3436 O OG1 . THR C 3 185 ? 154.651 146.645 177.541 1.00 43.88  ? 208 THR C OG1 1 
ATOM   3437 C CG2 . THR C 3 185 ? 153.070 146.376 179.311 1.00 43.88  ? 208 THR C CG2 1 
ATOM   3438 N N   . GLY C 3 186 ? 156.662 146.794 181.644 1.00 41.79  ? 209 GLY C N   1 
ATOM   3439 C CA  . GLY C 3 186 ? 156.902 146.452 183.028 1.00 41.79  ? 209 GLY C CA  1 
ATOM   3440 C C   . GLY C 3 186 ? 157.082 144.957 183.233 1.00 41.79  ? 209 GLY C C   1 
ATOM   3441 O O   . GLY C 3 186 ? 156.717 144.129 182.395 1.00 41.79  ? 209 GLY C O   1 
ATOM   3442 N N   . THR C 3 187 ? 157.658 144.612 184.381 1.00 42.07  ? 210 THR C N   1 
ATOM   3443 C CA  . THR C 3 187 ? 157.918 143.230 184.760 1.00 42.07  ? 210 THR C CA  1 
ATOM   3444 C C   . THR C 3 187 ? 156.854 142.787 185.755 1.00 42.07  ? 210 THR C C   1 
ATOM   3445 O O   . THR C 3 187 ? 156.744 143.359 186.845 1.00 42.07  ? 210 THR C O   1 
ATOM   3446 C CB  . THR C 3 187 ? 159.314 143.079 185.367 1.00 42.07  ? 210 THR C CB  1 
ATOM   3447 O OG1 . THR C 3 187 ? 160.302 143.443 184.395 1.00 42.07  ? 210 THR C OG1 1 
ATOM   3448 C CG2 . THR C 3 187 ? 159.549 141.645 185.810 1.00 42.07  ? 210 THR C CG2 1 
ATOM   3449 N N   . ASN C 3 188 ? 156.080 141.772 185.381 1.00 41.87  ? 211 ASN C N   1 
ATOM   3450 C CA  . ASN C 3 188 ? 154.991 141.297 186.222 1.00 41.87  ? 211 ASN C CA  1 
ATOM   3451 C C   . ASN C 3 188 ? 155.537 140.472 187.379 1.00 41.87  ? 211 ASN C C   1 
ATOM   3452 O O   . ASN C 3 188 ? 156.351 139.566 187.178 1.00 41.87  ? 211 ASN C O   1 
ATOM   3453 C CB  . ASN C 3 188 ? 154.009 140.467 185.397 1.00 41.87  ? 211 ASN C CB  1 
ATOM   3454 C CG  . ASN C 3 188 ? 153.417 141.245 184.241 1.00 41.87  ? 211 ASN C CG  1 
ATOM   3455 O OD1 . ASN C 3 188 ? 153.130 142.435 184.362 1.00 41.87  ? 211 ASN C OD1 1 
ATOM   3456 N ND2 . ASN C 3 188 ? 153.236 140.576 183.110 1.00 41.87  ? 211 ASN C ND2 1 
ATOM   3457 N N   . ILE C 3 189 ? 155.086 140.787 188.591 1.00 43.35  ? 212 ILE C N   1 
ATOM   3458 C CA  . ILE C 3 189 ? 155.489 140.048 189.782 1.00 43.35  ? 212 ILE C CA  1 
ATOM   3459 C C   . ILE C 3 189 ? 154.278 139.312 190.336 1.00 43.35  ? 212 ILE C C   1 
ATOM   3460 O O   . ILE C 3 189 ? 153.509 139.867 191.127 1.00 43.35  ? 212 ILE C O   1 
ATOM   3461 C CB  . ILE C 3 189 ? 156.103 140.981 190.841 1.00 43.35  ? 212 ILE C CB  1 
ATOM   3462 C CG1 . ILE C 3 189 ? 157.256 141.784 190.239 1.00 43.35  ? 212 ILE C CG1 1 
ATOM   3463 C CG2 . ILE C 3 189 ? 156.582 140.182 192.043 1.00 43.35  ? 212 ILE C CG2 1 
ATOM   3464 C CD1 . ILE C 3 189 ? 157.934 142.708 191.224 1.00 43.35  ? 212 ILE C CD1 1 
ATOM   3465 N N   . ASN C 3 190 ? 154.100 138.060 189.925 1.00 50.35  ? 213 ASN C N   1 
ATOM   3466 C CA  . ASN C 3 190 ? 152.966 137.257 190.359 1.00 50.35  ? 213 ASN C CA  1 
ATOM   3467 C C   . ASN C 3 190 ? 153.332 136.478 191.615 1.00 50.35  ? 213 ASN C C   1 
ATOM   3468 O O   . ASN C 3 190 ? 154.398 135.860 191.682 1.00 50.35  ? 213 ASN C O   1 
ATOM   3469 C CB  . ASN C 3 190 ? 152.524 136.302 189.250 1.00 50.35  ? 213 ASN C CB  1 
ATOM   3470 C CG  . ASN C 3 190 ? 153.663 135.455 188.722 1.00 50.35  ? 213 ASN C CG  1 
ATOM   3471 O OD1 . ASN C 3 190 ? 153.927 134.366 189.229 1.00 50.35  ? 213 ASN C OD1 1 
ATOM   3472 N ND2 . ASN C 3 190 ? 154.344 135.952 187.697 1.00 50.35  ? 213 ASN C ND2 1 
ATOM   3473 N N   . CYS C 3 191 ? 152.444 136.511 192.607 1.00 60.13  ? 214 CYS C N   1 
ATOM   3474 C CA  . CYS C 3 191 ? 152.658 135.840 193.885 1.00 60.13  ? 214 CYS C CA  1 
ATOM   3475 C C   . CYS C 3 191 ? 151.434 134.988 194.193 1.00 60.13  ? 214 CYS C C   1 
ATOM   3476 O O   . CYS C 3 191 ? 150.333 135.519 194.371 1.00 60.13  ? 214 CYS C O   1 
ATOM   3477 C CB  . CYS C 3 191 ? 152.918 136.851 195.001 1.00 60.13  ? 214 CYS C CB  1 
ATOM   3478 S SG  . CYS C 3 191 ? 153.475 136.113 196.551 1.00 60.13  ? 214 CYS C SG  1 
ATOM   3479 N N   . GLN C 3 192 ? 151.626 133.675 194.256 1.00 69.93  ? 215 GLN C N   1 
ATOM   3480 C CA  . GLN C 3 192 ? 150.546 132.725 194.473 1.00 69.93  ? 215 GLN C CA  1 
ATOM   3481 C C   . GLN C 3 192 ? 150.770 131.961 195.771 1.00 69.93  ? 215 GLN C C   1 
ATOM   3482 O O   . GLN C 3 192 ? 151.881 131.493 196.043 1.00 69.93  ? 215 GLN C O   1 
ATOM   3483 C CB  . GLN C 3 192 ? 150.445 131.746 193.302 1.00 69.93  ? 215 GLN C CB  1 
ATOM   3484 C CG  . GLN C 3 192 ? 149.334 130.723 193.435 1.00 69.93  ? 215 GLN C CG  1 
ATOM   3485 C CD  . GLN C 3 192 ? 149.320 129.739 192.286 1.00 69.93  ? 215 GLN C CD  1 
ATOM   3486 O OE1 . GLN C 3 192 ? 150.223 129.732 191.451 1.00 69.93  ? 215 GLN C OE1 1 
ATOM   3487 N NE2 . GLN C 3 192 ? 148.291 128.903 192.233 1.00 69.93  ? 215 GLN C NE2 1 
ATOM   3488 N N   . ALA C 3 193 ? 149.712 131.837 196.568 1.00 77.95  ? 216 ALA C N   1 
ATOM   3489 C CA  . ALA C 3 193 ? 149.791 131.101 197.820 1.00 77.95  ? 216 ALA C CA  1 
ATOM   3490 C C   . ALA C 3 193 ? 149.476 129.629 197.599 1.00 77.95  ? 216 ALA C C   1 
ATOM   3491 O O   . ALA C 3 193 ? 148.491 129.278 196.944 1.00 77.95  ? 216 ALA C O   1 
ATOM   3492 C CB  . ALA C 3 193 ? 148.829 131.690 198.852 1.00 77.95  ? 216 ALA C CB  1 
ATOM   3493 N N   . THR C 3 194 ? 150.319 128.765 198.167 1.00 86.50  ? 217 THR C N   1 
ATOM   3494 C CA  . THR C 3 194 ? 150.111 127.328 198.027 1.00 86.50  ? 217 THR C CA  1 
ATOM   3495 C C   . THR C 3 194 ? 148.936 126.858 198.876 1.00 86.50  ? 217 THR C C   1 
ATOM   3496 O O   . THR C 3 194 ? 148.106 126.065 198.419 1.00 86.50  ? 217 THR C O   1 
ATOM   3497 C CB  . THR C 3 194 ? 151.392 126.570 198.391 1.00 86.50  ? 217 THR C CB  1 
ATOM   3498 O OG1 . THR C 3 194 ? 151.113 125.166 198.463 1.00 86.50  ? 217 THR C OG1 1 
ATOM   3499 C CG2 . THR C 3 194 ? 151.971 127.049 199.718 1.00 86.50  ? 217 THR C CG2 1 
ATOM   3500 N N   . LYS C 3 195 ? 148.847 127.337 200.112 1.00 88.10  ? 218 LYS C N   1 
ATOM   3501 C CA  . LYS C 3 195 ? 147.761 126.995 201.016 1.00 88.10  ? 218 LYS C CA  1 
ATOM   3502 C C   . LYS C 3 195 ? 146.799 128.169 201.146 1.00 88.10  ? 218 LYS C C   1 
ATOM   3503 O O   . LYS C 3 195 ? 147.116 129.312 200.805 1.00 88.10  ? 218 LYS C O   1 
ATOM   3504 C CB  . LYS C 3 195 ? 148.302 126.591 202.393 1.00 88.10  ? 218 LYS C CB  1 
ATOM   3505 C CG  . LYS C 3 195 ? 149.428 125.570 202.347 1.00 88.10  ? 218 LYS C CG  1 
ATOM   3506 C CD  . LYS C 3 195 ? 149.851 125.149 203.745 1.00 88.10  ? 218 LYS C CD  1 
ATOM   3507 C CE  . LYS C 3 195 ? 150.974 124.128 203.691 1.00 88.10  ? 218 LYS C CE  1 
ATOM   3508 N NZ  . LYS C 3 195 ? 150.783 123.038 204.685 1.00 88.10  ? 218 LYS C NZ  1 
ATOM   3509 N N   . GLY C 3 196 ? 145.607 127.866 201.649 1.00 91.09  ? 219 GLY C N   1 
ATOM   3510 C CA  . GLY C 3 196 ? 144.568 128.855 201.794 1.00 91.09  ? 219 GLY C CA  1 
ATOM   3511 C C   . GLY C 3 196 ? 143.845 129.112 200.488 1.00 91.09  ? 219 GLY C C   1 
ATOM   3512 O O   . GLY C 3 196 ? 143.661 128.211 199.663 1.00 91.09  ? 219 GLY C O   1 
ATOM   3513 N N   . PRO C 3 197 ? 143.413 130.356 200.280 1.00 87.65  ? 220 PRO C N   1 
ATOM   3514 C CA  . PRO C 3 197 ? 142.742 130.717 199.021 1.00 87.65  ? 220 PRO C CA  1 
ATOM   3515 C C   . PRO C 3 197 ? 143.700 130.611 197.842 1.00 87.65  ? 220 PRO C C   1 
ATOM   3516 O O   . PRO C 3 197 ? 144.742 131.268 197.811 1.00 87.65  ? 220 PRO C O   1 
ATOM   3517 C CB  . PRO C 3 197 ? 142.294 132.165 199.259 1.00 87.65  ? 220 PRO C CB  1 
ATOM   3518 C CG  . PRO C 3 197 ? 142.279 132.324 200.749 1.00 87.65  ? 220 PRO C CG  1 
ATOM   3519 C CD  . PRO C 3 197 ? 143.390 131.458 201.255 1.00 87.65  ? 220 PRO C CD  1 
ATOM   3520 N N   . LYS C 3 198 ? 143.335 129.780 196.868 1.00 82.84  ? 221 LYS C N   1 
ATOM   3521 C CA  . LYS C 3 198 ? 144.147 129.558 195.672 1.00 82.84  ? 221 LYS C CA  1 
ATOM   3522 C C   . LYS C 3 198 ? 143.808 130.636 194.649 1.00 82.84  ? 221 LYS C C   1 
ATOM   3523 O O   . LYS C 3 198 ? 142.775 130.569 193.979 1.00 82.84  ? 221 LYS C O   1 
ATOM   3524 C CB  . LYS C 3 198 ? 143.900 128.163 195.108 1.00 82.84  ? 221 LYS C CB  1 
ATOM   3525 C CG  . LYS C 3 198 ? 144.918 127.708 194.071 1.00 82.84  ? 221 LYS C CG  1 
ATOM   3526 C CD  . LYS C 3 198 ? 146.337 127.748 194.610 1.00 82.84  ? 221 LYS C CD  1 
ATOM   3527 C CE  . LYS C 3 198 ? 146.515 126.771 195.759 1.00 82.84  ? 221 LYS C CE  1 
ATOM   3528 N NZ  . LYS C 3 198 ? 147.851 126.114 195.727 1.00 82.84  ? 221 LYS C NZ  1 
ATOM   3529 N N   . ARG C 3 199 ? 144.680 131.632 194.525 1.00 76.22  ? 222 ARG C N   1 
ATOM   3530 C CA  . ARG C 3 199 ? 144.500 132.698 193.548 1.00 76.22  ? 222 ARG C CA  1 
ATOM   3531 C C   . ARG C 3 199 ? 145.859 133.327 193.269 1.00 76.22  ? 222 ARG C C   1 
ATOM   3532 O O   . ARG C 3 199 ? 146.879 132.932 193.841 1.00 76.22  ? 222 ARG C O   1 
ATOM   3533 C CB  . ARG C 3 199 ? 143.484 133.734 194.036 1.00 76.22  ? 222 ARG C CB  1 
ATOM   3534 C CG  . ARG C 3 199 ? 142.522 134.204 192.957 1.00 76.22  ? 222 ARG C CG  1 
ATOM   3535 C CD  . ARG C 3 199 ? 141.404 135.052 193.537 1.00 76.22  ? 222 ARG C CD  1 
ATOM   3536 N NE  . ARG C 3 199 ? 140.382 135.358 192.540 1.00 76.22  ? 222 ARG C NE  1 
ATOM   3537 C CZ  . ARG C 3 199 ? 139.288 136.071 192.787 1.00 76.22  ? 222 ARG C CZ  1 
ATOM   3538 N NH1 . ARG C 3 199 ? 139.069 136.555 194.002 1.00 76.22  ? 222 ARG C NH1 1 
ATOM   3539 N NH2 . ARG C 3 199 ? 138.411 136.301 191.819 1.00 76.22  ? 222 ARG C NH2 1 
ATOM   3540 N N   . ILE C 3 200 ? 145.866 134.316 192.379 1.00 60.62  ? 223 ILE C N   1 
ATOM   3541 C CA  . ILE C 3 200 ? 147.085 134.992 191.951 1.00 60.62  ? 223 ILE C CA  1 
ATOM   3542 C C   . ILE C 3 200 ? 146.918 136.487 192.183 1.00 60.62  ? 223 ILE C C   1 
ATOM   3543 O O   . ILE C 3 200 ? 145.923 137.080 191.750 1.00 60.62  ? 223 ILE C O   1 
ATOM   3544 C CB  . ILE C 3 200 ? 147.407 134.698 190.475 1.00 60.62  ? 223 ILE C CB  1 
ATOM   3545 C CG1 . ILE C 3 200 ? 147.892 133.256 190.317 1.00 60.62  ? 223 ILE C CG1 1 
ATOM   3546 C CG2 . ILE C 3 200 ? 148.445 135.673 189.946 1.00 60.62  ? 223 ILE C CG2 1 
ATOM   3547 C CD1 . ILE C 3 200 ? 148.368 132.923 188.924 1.00 60.62  ? 223 ILE C CD1 1 
ATOM   3548 N N   . PHE C 3 201 ? 147.891 137.089 192.865 1.00 54.81  ? 224 PHE C N   1 
ATOM   3549 C CA  . PHE C 3 201 ? 147.890 138.518 193.136 1.00 54.81  ? 224 PHE C CA  1 
ATOM   3550 C C   . PHE C 3 201 ? 149.309 139.051 193.009 1.00 54.81  ? 224 PHE C C   1 
ATOM   3551 O O   . PHE C 3 201 ? 150.279 138.355 193.318 1.00 54.81  ? 224 PHE C O   1 
ATOM   3552 C CB  . PHE C 3 201 ? 147.330 138.833 194.531 1.00 54.81  ? 224 PHE C CB  1 
ATOM   3553 C CG  . PHE C 3 201 ? 148.069 138.155 195.651 1.00 54.81  ? 224 PHE C CG  1 
ATOM   3554 C CD1 . PHE C 3 201 ? 147.721 136.877 196.055 1.00 54.81  ? 224 PHE C CD1 1 
ATOM   3555 C CD2 . PHE C 3 201 ? 149.106 138.798 196.305 1.00 54.81  ? 224 PHE C CD2 1 
ATOM   3556 C CE1 . PHE C 3 201 ? 148.397 136.253 197.085 1.00 54.81  ? 224 PHE C CE1 1 
ATOM   3557 C CE2 . PHE C 3 201 ? 149.786 138.178 197.335 1.00 54.81  ? 224 PHE C CE2 1 
ATOM   3558 C CZ  . PHE C 3 201 ? 149.431 136.904 197.725 1.00 54.81  ? 224 PHE C CZ  1 
ATOM   3559 N N   . GLY C 3 202 ? 149.421 140.293 192.554 1.00 48.70  ? 225 GLY C N   1 
ATOM   3560 C CA  . GLY C 3 202 ? 150.726 140.910 192.402 1.00 48.70  ? 225 GLY C CA  1 
ATOM   3561 C C   . GLY C 3 202 ? 150.598 142.271 191.755 1.00 48.70  ? 225 GLY C C   1 
ATOM   3562 O O   . GLY C 3 202 ? 149.499 142.735 191.435 1.00 48.70  ? 225 GLY C O   1 
ATOM   3563 N N   . THR C 3 203 ? 151.751 142.911 191.569 1.00 44.25  ? 226 THR C N   1 
ATOM   3564 C CA  . THR C 3 203 ? 151.832 144.234 190.969 1.00 44.25  ? 226 THR C CA  1 
ATOM   3565 C C   . THR C 3 203 ? 152.821 144.210 189.812 1.00 44.25  ? 226 THR C C   1 
ATOM   3566 O O   . THR C 3 203 ? 153.555 143.240 189.608 1.00 44.25  ? 226 THR C O   1 
ATOM   3567 C CB  . THR C 3 203 ? 152.256 145.301 191.989 1.00 44.25  ? 226 THR C CB  1 
ATOM   3568 O OG1 . THR C 3 203 ? 153.672 145.232 192.194 1.00 44.25  ? 226 THR C OG1 1 
ATOM   3569 C CG2 . THR C 3 203 ? 151.545 145.096 193.315 1.00 44.25  ? 226 THR C CG2 1 
ATOM   3570 N N   . VAL C 3 204 ? 152.832 145.301 189.050 1.00 38.81  ? 227 VAL C N   1 
ATOM   3571 C CA  . VAL C 3 204 ? 153.738 145.474 187.922 1.00 38.81  ? 227 VAL C CA  1 
ATOM   3572 C C   . VAL C 3 204 ? 154.842 146.437 188.333 1.00 38.81  ? 227 VAL C C   1 
ATOM   3573 O O   . VAL C 3 204 ? 154.571 147.486 188.930 1.00 38.81  ? 227 VAL C O   1 
ATOM   3574 C CB  . VAL C 3 204 ? 152.990 145.992 186.682 1.00 38.81  ? 227 VAL C CB  1 
ATOM   3575 C CG1 . VAL C 3 204 ? 153.947 146.171 185.518 1.00 38.81  ? 227 VAL C CG1 1 
ATOM   3576 C CG2 . VAL C 3 204 ? 151.866 145.043 186.311 1.00 38.81  ? 227 VAL C CG2 1 
ATOM   3577 N N   . LEU C 3 205 ? 156.086 146.083 188.018 1.00 40.29  ? 228 LEU C N   1 
ATOM   3578 C CA  . LEU C 3 205 ? 157.246 146.907 188.338 1.00 40.29  ? 228 LEU C CA  1 
ATOM   3579 C C   . LEU C 3 205 ? 157.731 147.577 187.057 1.00 40.29  ? 228 LEU C C   1 
ATOM   3580 O O   . LEU C 3 205 ? 158.286 146.915 186.175 1.00 40.29  ? 228 LEU C O   1 
ATOM   3581 C CB  . LEU C 3 205 ? 158.351 146.064 188.971 1.00 40.29  ? 228 LEU C CB  1 
ATOM   3582 C CG  . LEU C 3 205 ? 159.633 146.803 189.357 1.00 40.29  ? 228 LEU C CG  1 
ATOM   3583 C CD1 . LEU C 3 205 ? 159.346 147.854 190.416 1.00 40.29  ? 228 LEU C CD1 1 
ATOM   3584 C CD2 . LEU C 3 205 ? 160.690 145.824 189.840 1.00 40.29  ? 228 LEU C CD2 1 
ATOM   3585 N N   . PHE C 3 206 ? 157.522 148.887 186.959 1.00 41.86  ? 229 PHE C N   1 
ATOM   3586 C CA  . PHE C 3 206 ? 157.918 149.651 185.782 1.00 41.86  ? 229 PHE C CA  1 
ATOM   3587 C C   . PHE C 3 206 ? 159.381 150.057 185.908 1.00 41.86  ? 229 PHE C C   1 
ATOM   3588 O O   . PHE C 3 206 ? 159.762 150.739 186.866 1.00 41.86  ? 229 PHE C O   1 
ATOM   3589 C CB  . PHE C 3 206 ? 157.033 150.886 185.616 1.00 41.86  ? 229 PHE C CB  1 
ATOM   3590 C CG  . PHE C 3 206 ? 155.667 150.586 185.071 1.00 41.86  ? 229 PHE C CG  1 
ATOM   3591 C CD1 . PHE C 3 206 ? 155.458 150.483 183.707 1.00 41.86  ? 229 PHE C CD1 1 
ATOM   3592 C CD2 . PHE C 3 206 ? 154.589 150.414 185.922 1.00 41.86  ? 229 PHE C CD2 1 
ATOM   3593 C CE1 . PHE C 3 206 ? 154.203 150.210 183.202 1.00 41.86  ? 229 PHE C CE1 1 
ATOM   3594 C CE2 . PHE C 3 206 ? 153.331 150.140 185.422 1.00 41.86  ? 229 PHE C CE2 1 
ATOM   3595 C CZ  . PHE C 3 206 ? 153.138 150.038 184.061 1.00 41.86  ? 229 PHE C CZ  1 
ATOM   3596 N N   . VAL C 3 207 ? 160.196 149.638 184.943 1.00 46.91  ? 230 VAL C N   1 
ATOM   3597 C CA  . VAL C 3 207 ? 161.612 149.979 184.891 1.00 46.91  ? 230 VAL C CA  1 
ATOM   3598 C C   . VAL C 3 207 ? 161.851 150.817 183.644 1.00 46.91  ? 230 VAL C C   1 
ATOM   3599 O O   . VAL C 3 207 ? 161.441 150.429 182.544 1.00 46.91  ? 230 VAL C O   1 
ATOM   3600 C CB  . VAL C 3 207 ? 162.501 148.722 184.886 1.00 46.91  ? 230 VAL C CB  1 
ATOM   3601 C CG1 . VAL C 3 207 ? 163.968 149.112 184.850 1.00 46.91  ? 230 VAL C CG1 1 
ATOM   3602 C CG2 . VAL C 3 207 ? 162.206 147.860 186.101 1.00 46.91  ? 230 VAL C CG2 1 
ATOM   3603 N N   . SER C 3 208 ? 162.508 151.960 183.816 1.00 52.36  ? 231 SER C N   1 
ATOM   3604 C CA  . SER C 3 208 ? 162.783 152.880 182.724 1.00 52.36  ? 231 SER C CA  1 
ATOM   3605 C C   . SER C 3 208 ? 164.284 152.978 182.487 1.00 52.36  ? 231 SER C C   1 
ATOM   3606 O O   . SER C 3 208 ? 165.096 152.634 183.350 1.00 52.36  ? 231 SER C O   1 
ATOM   3607 C CB  . SER C 3 208 ? 162.209 154.272 183.011 1.00 52.36  ? 231 SER C CB  1 
ATOM   3608 O OG  . SER C 3 208 ? 162.956 154.930 184.018 1.00 52.36  ? 231 SER C OG  1 
ATOM   3609 N N   . LYS C 3 209 ? 164.644 153.460 181.300 1.00 54.97  ? 232 LYS C N   1 
ATOM   3610 C CA  . LYS C 3 209 ? 166.040 153.596 180.921 1.00 54.97  ? 232 LYS C CA  1 
ATOM   3611 C C   . LYS C 3 209 ? 166.630 154.877 181.508 1.00 54.97  ? 232 LYS C C   1 
ATOM   3612 O O   . LYS C 3 209 ? 165.944 155.675 182.152 1.00 54.97  ? 232 LYS C O   1 
ATOM   3613 C CB  . LYS C 3 209 ? 166.181 153.572 179.402 1.00 54.97  ? 232 LYS C CB  1 
ATOM   3614 C CG  . LYS C 3 209 ? 165.754 152.265 178.760 1.00 54.97  ? 232 LYS C CG  1 
ATOM   3615 C CD  . LYS C 3 209 ? 165.975 152.294 177.259 1.00 54.97  ? 232 LYS C CD  1 
ATOM   3616 C CE  . LYS C 3 209 ? 165.620 150.963 176.620 1.00 54.97  ? 232 LYS C CE  1 
ATOM   3617 N NZ  . LYS C 3 209 ? 165.852 150.977 175.150 1.00 54.97  ? 232 LYS C NZ  1 
ATOM   3618 N N   . VAL C 3 210 ? 167.924 155.076 181.280 1.00 56.52  ? 233 VAL C N   1 
ATOM   3619 C CA  . VAL C 3 210 ? 168.635 156.244 181.783 1.00 56.52  ? 233 VAL C CA  1 
ATOM   3620 C C   . VAL C 3 210 ? 168.578 157.346 180.734 1.00 56.52  ? 233 VAL C C   1 
ATOM   3621 O O   . VAL C 3 210 ? 168.835 157.103 179.549 1.00 56.52  ? 233 VAL C O   1 
ATOM   3622 C CB  . VAL C 3 210 ? 170.090 155.892 182.135 1.00 56.52  ? 233 VAL C CB  1 
ATOM   3623 C CG1 . VAL C 3 210 ? 170.806 157.104 182.712 1.00 56.52  ? 233 VAL C CG1 1 
ATOM   3624 C CG2 . VAL C 3 210 ? 170.131 154.727 183.111 1.00 56.52  ? 233 VAL C CG2 1 
ATOM   3625 N N   . LEU C 3 211 ? 168.241 158.557 181.168 1.00 59.34  ? 234 LEU C N   1 
ATOM   3626 C CA  . LEU C 3 211 ? 168.145 159.694 180.263 1.00 59.34  ? 234 LEU C CA  1 
ATOM   3627 C C   . LEU C 3 211 ? 169.538 160.201 179.911 1.00 59.34  ? 234 LEU C C   1 
ATOM   3628 O O   . LEU C 3 211 ? 170.363 160.446 180.797 1.00 59.34  ? 234 LEU C O   1 
ATOM   3629 C CB  . LEU C 3 211 ? 167.318 160.810 180.899 1.00 59.34  ? 234 LEU C CB  1 
ATOM   3630 C CG  . LEU C 3 211 ? 167.183 162.103 180.095 1.00 59.34  ? 234 LEU C CG  1 
ATOM   3631 C CD1 . LEU C 3 211 ? 166.536 161.827 178.751 1.00 59.34  ? 234 LEU C CD1 1 
ATOM   3632 C CD2 . LEU C 3 211 ? 166.385 163.134 180.874 1.00 59.34  ? 234 LEU C CD2 1 
ATOM   3633 N N   . GLU C 3 212 ? 169.797 160.357 178.617 1.00 67.63  ? 235 GLU C N   1 
ATOM   3634 C CA  . GLU C 3 212 ? 171.087 160.816 178.126 1.00 67.63  ? 235 GLU C CA  1 
ATOM   3635 C C   . GLU C 3 212 ? 171.050 162.311 177.829 1.00 67.63  ? 235 GLU C C   1 
ATOM   3636 O O   . GLU C 3 212 ? 169.990 162.935 177.747 1.00 67.63  ? 235 GLU C O   1 
ATOM   3637 C CB  . GLU C 3 212 ? 171.497 160.032 176.876 1.00 67.63  ? 235 GLU C CB  1 
ATOM   3638 C CG  . GLU C 3 212 ? 172.086 158.663 177.170 1.00 67.63  ? 235 GLU C CG  1 
ATOM   3639 C CD  . GLU C 3 212 ? 171.954 157.709 176.001 1.00 67.63  ? 235 GLU C CD  1 
ATOM   3640 O OE1 . GLU C 3 212 ? 171.851 156.487 176.239 1.00 67.63  ? 235 GLU C OE1 1 
ATOM   3641 O OE2 . GLU C 3 212 ? 171.954 158.180 174.845 1.00 67.63  ? 235 GLU C OE2 1 
ATOM   3642 N N   . GLU C 3 213 ? 172.240 162.882 177.665 1.00 66.79  ? 236 GLU C N   1 
ATOM   3643 C CA  . GLU C 3 213 ? 172.498 164.288 177.382 1.00 66.79  ? 236 GLU C CA  1 
ATOM   3644 C C   . GLU C 3 213 ? 172.500 164.533 175.875 1.00 66.79  ? 236 GLU C C   1 
ATOM   3645 O O   . GLU C 3 213 ? 173.056 163.732 175.118 1.00 66.79  ? 236 GLU C O   1 
ATOM   3646 C CB  . GLU C 3 213 ? 173.840 164.713 177.972 1.00 66.79  ? 236 GLU C CB  1 
ATOM   3647 C CG  . GLU C 3 213 ? 174.062 166.212 178.025 1.00 66.79  ? 236 GLU C CG  1 
ATOM   3648 C CD  . GLU C 3 213 ? 175.363 166.579 178.709 1.00 66.79  ? 236 GLU C CD  1 
ATOM   3649 O OE1 . GLU C 3 213 ? 176.222 165.687 178.869 1.00 66.79  ? 236 GLU C OE1 1 
ATOM   3650 O OE2 . GLU C 3 213 ? 175.526 167.757 179.087 1.00 66.79  ? 236 GLU C OE2 1 
ATOM   3651 N N   . PRO C 3 214 ? 171.875 165.618 175.417 1.00 67.19  ? 237 PRO C N   1 
ATOM   3652 C CA  . PRO C 3 214 ? 171.879 165.917 173.980 1.00 67.19  ? 237 PRO C CA  1 
ATOM   3653 C C   . PRO C 3 214 ? 173.294 166.127 173.462 1.00 67.19  ? 237 PRO C C   1 
ATOM   3654 O O   . PRO C 3 214 ? 174.090 166.862 174.050 1.00 67.19  ? 237 PRO C O   1 
ATOM   3655 C CB  . PRO C 3 214 ? 171.047 167.200 173.882 1.00 67.19  ? 237 PRO C CB  1 
ATOM   3656 C CG  . PRO C 3 214 ? 170.198 167.198 175.109 1.00 67.19  ? 237 PRO C CG  1 
ATOM   3657 C CD  . PRO C 3 214 ? 171.031 166.557 176.176 1.00 67.19  ? 237 PRO C CD  1 
ATOM   3658 N N   . LYS C 3 215 ? 173.601 165.473 172.345 1.00 70.98  ? 238 LYS C N   1 
ATOM   3659 C CA  . LYS C 3 215 ? 174.935 165.489 171.764 1.00 70.98  ? 238 LYS C CA  1 
ATOM   3660 C C   . LYS C 3 215 ? 174.935 166.277 170.461 1.00 70.98  ? 238 LYS C C   1 
ATOM   3661 O O   . LYS C 3 215 ? 173.990 166.188 169.670 1.00 70.98  ? 238 LYS C O   1 
ATOM   3662 C CB  . LYS C 3 215 ? 175.440 164.066 171.513 1.00 70.98  ? 238 LYS C CB  1 
ATOM   3663 C CG  . LYS C 3 215 ? 175.639 163.248 172.778 1.00 70.98  ? 238 LYS C CG  1 
ATOM   3664 C CD  . LYS C 3 215 ? 176.233 161.885 172.465 1.00 70.98  ? 238 LYS C CD  1 
ATOM   3665 C CE  . LYS C 3 215 ? 176.497 161.094 173.735 1.00 70.98  ? 238 LYS C CE  1 
ATOM   3666 N NZ  . LYS C 3 215 ? 177.091 159.759 173.444 1.00 70.98  ? 238 LYS C NZ  1 
ATOM   3667 N N   . ASN C 3 216 ? 176.005 167.039 170.247 1.00 76.19  ? 239 ASN C N   1 
ATOM   3668 C CA  . ASN C 3 216 ? 176.194 167.858 169.050 1.00 76.19  ? 239 ASN C CA  1 
ATOM   3669 C C   . ASN C 3 216 ? 175.016 168.811 168.842 1.00 76.19  ? 239 ASN C C   1 
ATOM   3670 O O   . ASN C 3 216 ? 174.281 168.740 167.856 1.00 76.19  ? 239 ASN C O   1 
ATOM   3671 C CB  . ASN C 3 216 ? 176.428 166.984 167.814 1.00 76.19  ? 239 ASN C CB  1 
ATOM   3672 C CG  . ASN C 3 216 ? 177.457 167.584 166.867 1.00 76.19  ? 239 ASN C CG  1 
ATOM   3673 O OD1 . ASN C 3 216 ? 177.732 168.781 166.945 1.00 76.19  ? 239 ASN C OD1 1 
ATOM   3674 N ND2 . ASN C 3 216 ? 178.037 166.771 165.974 1.00 76.19  ? 239 ASN C ND2 1 
ATOM   3675 N N   . VAL C 3 217 ? 174.850 169.714 169.804 1.00 71.82  ? 240 VAL C N   1 
ATOM   3676 C CA  . VAL C 3 217 ? 173.803 170.728 169.755 1.00 71.82  ? 240 VAL C CA  1 
ATOM   3677 C C   . VAL C 3 217 ? 174.351 171.929 168.993 1.00 71.82  ? 240 VAL C C   1 
ATOM   3678 O O   . VAL C 3 217 ? 175.335 172.545 169.410 1.00 71.82  ? 240 VAL C O   1 
ATOM   3679 C CB  . VAL C 3 217 ? 173.341 171.128 171.161 1.00 71.82  ? 240 VAL C CB  1 
ATOM   3680 C CG1 . VAL C 3 217 ? 172.265 172.199 171.081 1.00 71.82  ? 240 VAL C CG1 1 
ATOM   3681 C CG2 . VAL C 3 217 ? 172.837 169.911 171.921 1.00 71.82  ? 240 VAL C CG2 1 
ATOM   3682 N N   . SER C 3 218 ? 173.715 172.262 167.872 1.00 74.74  ? 241 SER C N   1 
ATOM   3683 C CA  . SER C 3 218 ? 174.123 173.400 167.062 1.00 74.74  ? 241 SER C CA  1 
ATOM   3684 C C   . SER C 3 218 ? 172.899 174.017 166.402 1.00 74.74  ? 241 SER C C   1 
ATOM   3685 O O   . SER C 3 218 ? 171.920 173.327 166.105 1.00 74.74  ? 241 SER C O   1 
ATOM   3686 C CB  . SER C 3 218 ? 175.148 172.997 165.994 1.00 74.74  ? 241 SER C CB  1 
ATOM   3687 O OG  . SER C 3 218 ? 174.506 172.554 164.811 1.00 74.74  ? 241 SER C OG  1 
ATOM   3688 N N   . CYS C 3 219 ? 172.967 175.326 166.172 1.00 80.64  ? 242 CYS C N   1 
ATOM   3689 C CA  . CYS C 3 219 ? 171.890 176.073 165.543 1.00 80.64  ? 242 CYS C CA  1 
ATOM   3690 C C   . CYS C 3 219 ? 172.451 176.886 164.383 1.00 80.64  ? 242 CYS C C   1 
ATOM   3691 O O   . CYS C 3 219 ? 173.666 177.007 164.209 1.00 80.64  ? 242 CYS C O   1 
ATOM   3692 C CB  . CYS C 3 219 ? 171.178 176.988 166.549 1.00 80.64  ? 242 CYS C CB  1 
ATOM   3693 S SG  . CYS C 3 219 ? 169.482 177.416 166.087 1.00 80.64  ? 242 CYS C SG  1 
ATOM   3694 N N   . GLU C 3 220 ? 171.547 177.449 163.585 1.00 77.39  ? 243 GLU C N   1 
ATOM   3695 C CA  . GLU C 3 220 ? 171.934 178.163 162.377 1.00 77.39  ? 243 GLU C CA  1 
ATOM   3696 C C   . GLU C 3 220 ? 170.860 179.183 162.032 1.00 77.39  ? 243 GLU C C   1 
ATOM   3697 O O   . GLU C 3 220 ? 169.737 179.127 162.539 1.00 77.39  ? 243 GLU C O   1 
ATOM   3698 C CB  . GLU C 3 220 ? 172.152 177.195 161.208 1.00 77.39  ? 243 GLU C CB  1 
ATOM   3699 C CG  . GLU C 3 220 ? 173.168 177.658 160.181 1.00 77.39  ? 243 GLU C CG  1 
ATOM   3700 C CD  . GLU C 3 220 ? 173.431 176.610 159.119 1.00 77.39  ? 243 GLU C CD  1 
ATOM   3701 O OE1 . GLU C 3 220 ? 172.483 175.885 158.751 1.00 77.39  ? 243 GLU C OE1 1 
ATOM   3702 O OE2 . GLU C 3 220 ? 174.587 176.506 158.657 1.00 77.39  ? 243 GLU C OE2 1 
ATOM   3703 N N   . THR C 3 221 ? 171.220 180.123 161.160 1.00 78.48  ? 244 THR C N   1 
ATOM   3704 C CA  . THR C 3 221 ? 170.295 181.132 160.667 1.00 78.48  ? 244 THR C CA  1 
ATOM   3705 C C   . THR C 3 221 ? 170.298 181.124 159.145 1.00 78.48  ? 244 THR C C   1 
ATOM   3706 O O   . THR C 3 221 ? 171.305 180.793 158.512 1.00 78.48  ? 244 THR C O   1 
ATOM   3707 C CB  . THR C 3 221 ? 170.648 182.537 161.182 1.00 78.48  ? 244 THR C CB  1 
ATOM   3708 O OG1 . THR C 3 221 ? 169.710 183.487 160.665 1.00 78.48  ? 244 THR C OG1 1 
ATOM   3709 C CG2 . THR C 3 221 ? 172.052 182.932 160.753 1.00 78.48  ? 244 THR C CG2 1 
ATOM   3710 N N   . ARG C 3 222 ? 169.156 181.482 158.563 1.00 79.81  ? 245 ARG C N   1 
ATOM   3711 C CA  . ARG C 3 222 ? 168.993 181.481 157.114 1.00 79.81  ? 245 ARG C CA  1 
ATOM   3712 C C   . ARG C 3 222 ? 168.665 182.856 156.557 1.00 79.81  ? 245 ARG C C   1 
ATOM   3713 O O   . ARG C 3 222 ? 169.289 183.287 155.580 1.00 79.81  ? 245 ARG C O   1 
ATOM   3714 C CB  . ARG C 3 222 ? 167.902 180.476 156.710 1.00 79.81  ? 245 ARG C CB  1 
ATOM   3715 C CG  . ARG C 3 222 ? 167.677 180.378 155.210 1.00 79.81  ? 245 ARG C CG  1 
ATOM   3716 C CD  . ARG C 3 222 ? 168.952 179.986 154.481 1.00 79.81  ? 245 ARG C CD  1 
ATOM   3717 N NE  . ARG C 3 222 ? 169.418 178.657 154.867 1.00 79.81  ? 245 ARG C NE  1 
ATOM   3718 C CZ  . ARG C 3 222 ? 169.066 177.535 154.250 1.00 79.81  ? 245 ARG C CZ  1 
ATOM   3719 N NH1 . ARG C 3 222 ? 169.539 176.369 154.668 1.00 79.81  ? 245 ARG C NH1 1 
ATOM   3720 N NH2 . ARG C 3 222 ? 168.240 177.577 153.214 1.00 79.81  ? 245 ARG C NH2 1 
ATOM   3721 N N   . ASP C 3 223 ? 167.701 183.564 157.150 1.00 82.33  ? 246 ASP C N   1 
ATOM   3722 C CA  . ASP C 3 223 ? 167.285 184.864 156.637 1.00 82.33  ? 246 ASP C CA  1 
ATOM   3723 C C   . ASP C 3 223 ? 167.091 185.878 157.759 1.00 82.33  ? 246 ASP C C   1 
ATOM   3724 O O   . ASP C 3 223 ? 166.248 186.775 157.648 1.00 82.33  ? 246 ASP C O   1 
ATOM   3725 C CB  . ASP C 3 223 ? 165.999 184.745 155.817 1.00 82.33  ? 246 ASP C CB  1 
ATOM   3726 C CG  . ASP C 3 223 ? 164.842 184.194 156.627 1.00 82.33  ? 246 ASP C CG  1 
ATOM   3727 O OD1 . ASP C 3 223 ? 165.094 183.431 157.583 1.00 82.33  ? 246 ASP C OD1 1 
ATOM   3728 O OD2 . ASP C 3 223 ? 163.680 184.525 156.309 1.00 82.33  ? 246 ASP C OD2 1 
ATOM   3729 N N   . PHE C 3 224 ? 167.855 185.745 158.844 1.00 80.72  ? 247 PHE C N   1 
ATOM   3730 C CA  . PHE C 3 224 ? 167.812 186.657 159.987 1.00 80.72  ? 247 PHE C CA  1 
ATOM   3731 C C   . PHE C 3 224 ? 166.426 186.738 160.619 1.00 80.72  ? 247 PHE C C   1 
ATOM   3732 O O   . PHE C 3 224 ? 166.087 187.745 161.249 1.00 80.72  ? 247 PHE C O   1 
ATOM   3733 C CB  . PHE C 3 224 ? 168.297 188.059 159.598 1.00 80.72  ? 247 PHE C CB  1 
ATOM   3734 C CG  . PHE C 3 224 ? 169.784 188.157 159.418 1.00 80.72  ? 247 PHE C CG  1 
ATOM   3735 C CD1 . PHE C 3 224 ? 170.581 188.692 160.415 1.00 80.72  ? 247 PHE C CD1 1 
ATOM   3736 C CD2 . PHE C 3 224 ? 170.386 187.709 158.254 1.00 80.72  ? 247 PHE C CD2 1 
ATOM   3737 C CE1 . PHE C 3 224 ? 171.950 188.783 160.254 1.00 80.72  ? 247 PHE C CE1 1 
ATOM   3738 C CE2 . PHE C 3 224 ? 171.754 187.796 158.088 1.00 80.72  ? 247 PHE C CE2 1 
ATOM   3739 C CZ  . PHE C 3 224 ? 172.537 188.334 159.089 1.00 80.72  ? 247 PHE C CZ  1 
ATOM   3740 N N   . LYS C 3 225 ? 165.618 185.701 160.465 1.00 82.71  ? 248 LYS C N   1 
ATOM   3741 C CA  . LYS C 3 225 ? 164.279 185.673 161.044 1.00 82.71  ? 248 LYS C CA  1 
ATOM   3742 C C   . LYS C 3 225 ? 164.016 184.427 161.876 1.00 82.71  ? 248 LYS C C   1 
ATOM   3743 O O   . LYS C 3 225 ? 163.301 184.505 162.878 1.00 82.71  ? 248 LYS C O   1 
ATOM   3744 C CB  . LYS C 3 225 ? 163.223 185.789 159.931 1.00 82.71  ? 248 LYS C CB  1 
ATOM   3745 C CG  . LYS C 3 225 ? 163.301 187.084 159.138 1.00 82.71  ? 248 LYS C CG  1 
ATOM   3746 C CD  . LYS C 3 225 ? 162.294 187.102 158.000 1.00 82.71  ? 248 LYS C CD  1 
ATOM   3747 C CE  . LYS C 3 225 ? 162.407 188.381 157.185 1.00 82.71  ? 248 LYS C CE  1 
ATOM   3748 N NZ  . LYS C 3 225 ? 161.460 188.395 156.036 1.00 82.71  ? 248 LYS C NZ  1 
ATOM   3749 N N   . THR C 3 226 ? 164.569 183.280 161.487 1.00 80.82  ? 249 THR C N   1 
ATOM   3750 C CA  . THR C 3 226 ? 164.348 182.028 162.192 1.00 80.82  ? 249 THR C CA  1 
ATOM   3751 C C   . THR C 3 226 ? 165.682 181.369 162.512 1.00 80.82  ? 249 THR C C   1 
ATOM   3752 O O   . THR C 3 226 ? 166.673 181.555 161.801 1.00 80.82  ? 249 THR C O   1 
ATOM   3753 C CB  . THR C 3 226 ? 163.481 181.062 161.371 1.00 80.82  ? 249 THR C CB  1 
ATOM   3754 O OG1 . THR C 3 226 ? 163.960 181.017 160.021 1.00 80.82  ? 249 THR C OG1 1 
ATOM   3755 C CG2 . THR C 3 226 ? 162.031 181.516 161.375 1.00 80.82  ? 249 THR C CG2 1 
ATOM   3756 N N   . LEU C 3 227 ? 165.694 180.595 163.596 1.00 75.53  ? 250 LEU C N   1 
ATOM   3757 C CA  . LEU C 3 227 ? 166.865 179.836 164.025 1.00 75.53  ? 250 LEU C CA  1 
ATOM   3758 C C   . LEU C 3 227 ? 166.467 178.371 164.129 1.00 75.53  ? 250 LEU C C   1 
ATOM   3759 O O   . LEU C 3 227 ? 165.770 177.979 165.071 1.00 75.53  ? 250 LEU C O   1 
ATOM   3760 C CB  . LEU C 3 227 ? 167.401 180.355 165.358 1.00 75.53  ? 250 LEU C CB  1 
ATOM   3761 C CG  . LEU C 3 227 ? 167.779 181.834 165.425 1.00 75.53  ? 250 LEU C CG  1 
ATOM   3762 C CD1 . LEU C 3 227 ? 168.322 182.184 166.800 1.00 75.53  ? 250 LEU C CD1 1 
ATOM   3763 C CD2 . LEU C 3 227 ? 168.792 182.173 164.348 1.00 75.53  ? 250 LEU C CD2 1 
ATOM   3764 N N   . ASP C 3 228 ? 166.907 177.562 163.164 1.00 75.82  ? 251 ASP C N   1 
ATOM   3765 C CA  . ASP C 3 228 ? 166.579 176.136 163.140 1.00 75.82  ? 251 ASP C CA  1 
ATOM   3766 C C   . ASP C 3 228 ? 167.664 175.370 163.892 1.00 75.82  ? 251 ASP C C   1 
ATOM   3767 O O   . ASP C 3 228 ? 168.666 174.923 163.331 1.00 75.82  ? 251 ASP C O   1 
ATOM   3768 C CB  . ASP C 3 228 ? 166.425 175.644 161.707 1.00 75.82  ? 251 ASP C CB  1 
ATOM   3769 C CG  . ASP C 3 228 ? 167.476 176.217 160.778 1.00 75.82  ? 251 ASP C CG  1 
ATOM   3770 O OD1 . ASP C 3 228 ? 167.483 175.846 159.585 1.00 75.82  ? 251 ASP C OD1 1 
ATOM   3771 O OD2 . ASP C 3 228 ? 168.294 177.038 161.241 1.00 75.82  ? 251 ASP C OD2 1 
ATOM   3772 N N   . CYS C 3 229 ? 167.448 175.220 165.196 1.00 72.00  ? 252 CYS C N   1 
ATOM   3773 C CA  . CYS C 3 229 ? 168.366 174.483 166.052 1.00 72.00  ? 252 CYS C CA  1 
ATOM   3774 C C   . CYS C 3 229 ? 168.043 172.995 166.012 1.00 72.00  ? 252 CYS C C   1 
ATOM   3775 O O   . CYS C 3 229 ? 166.875 172.602 165.938 1.00 72.00  ? 252 CYS C O   1 
ATOM   3776 C CB  . CYS C 3 229 ? 168.294 174.995 167.491 1.00 72.00  ? 252 CYS C CB  1 
ATOM   3777 S SG  . CYS C 3 229 ? 168.352 176.796 167.658 1.00 72.00  ? 252 CYS C SG  1 
ATOM   3778 N N   . SER C 3 230 ? 169.087 172.170 166.060 1.00 66.81  ? 253 SER C N   1 
ATOM   3779 C CA  . SER C 3 230 ? 168.932 170.725 166.022 1.00 66.81  ? 253 SER C CA  1 
ATOM   3780 C C   . SER C 3 230 ? 169.887 170.089 167.021 1.00 66.81  ? 253 SER C C   1 
ATOM   3781 O O   . SER C 3 230 ? 170.905 170.674 167.398 1.00 66.81  ? 253 SER C O   1 
ATOM   3782 C CB  . SER C 3 230 ? 169.186 170.165 164.617 1.00 66.81  ? 253 SER C CB  1 
ATOM   3783 O OG  . SER C 3 230 ? 169.443 168.773 164.662 1.00 66.81  ? 253 SER C OG  1 
ATOM   3784 N N   . TRP C 3 231 ? 169.545 168.876 167.444 1.00 63.27  ? 254 TRP C N   1 
ATOM   3785 C CA  . TRP C 3 231 ? 170.340 168.144 168.421 1.00 63.27  ? 254 TRP C CA  1 
ATOM   3786 C C   . TRP C 3 231 ? 170.032 166.659 168.279 1.00 63.27  ? 254 TRP C C   1 
ATOM   3787 O O   . TRP C 3 231 ? 169.285 166.240 167.390 1.00 63.27  ? 254 TRP C O   1 
ATOM   3788 C CB  . TRP C 3 231 ? 170.063 168.639 169.844 1.00 63.27  ? 254 TRP C CB  1 
ATOM   3789 C CG  . TRP C 3 231 ? 168.623 168.535 170.246 1.00 63.27  ? 254 TRP C CG  1 
ATOM   3790 C CD1 . TRP C 3 231 ? 167.973 167.418 170.680 1.00 63.27  ? 254 TRP C CD1 1 
ATOM   3791 C CD2 . TRP C 3 231 ? 167.657 169.592 170.259 1.00 63.27  ? 254 TRP C CD2 1 
ATOM   3792 N NE1 . TRP C 3 231 ? 166.661 167.711 170.957 1.00 63.27  ? 254 TRP C NE1 1 
ATOM   3793 C CE2 . TRP C 3 231 ? 166.441 169.040 170.707 1.00 63.27  ? 254 TRP C CE2 1 
ATOM   3794 C CE3 . TRP C 3 231 ? 167.701 170.950 169.934 1.00 63.27  ? 254 TRP C CE3 1 
ATOM   3795 C CZ2 . TRP C 3 231 ? 165.280 169.798 170.839 1.00 63.27  ? 254 TRP C CZ2 1 
ATOM   3796 C CZ3 . TRP C 3 231 ? 166.547 171.702 170.065 1.00 63.27  ? 254 TRP C CZ3 1 
ATOM   3797 C CH2 . TRP C 3 231 ? 165.354 171.124 170.513 1.00 63.27  ? 254 TRP C CH2 1 
ATOM   3798 N N   . GLU C 3 232 ? 170.617 165.861 169.170 1.00 67.07  ? 255 GLU C N   1 
ATOM   3799 C CA  . GLU C 3 232 ? 170.384 164.427 169.211 1.00 67.07  ? 255 GLU C CA  1 
ATOM   3800 C C   . GLU C 3 232 ? 169.570 164.069 170.442 1.00 67.07  ? 255 GLU C C   1 
ATOM   3801 O O   . GLU C 3 232 ? 169.998 164.364 171.567 1.00 67.07  ? 255 GLU C O   1 
ATOM   3802 C CB  . GLU C 3 232 ? 171.710 163.661 169.222 1.00 67.07  ? 255 GLU C CB  1 
ATOM   3803 C CG  . GLU C 3 232 ? 172.474 163.709 167.907 1.00 67.07  ? 255 GLU C CG  1 
ATOM   3804 C CD  . GLU C 3 232 ? 171.591 163.440 166.703 1.00 67.07  ? 255 GLU C CD  1 
ATOM   3805 O OE1 . GLU C 3 232 ? 171.081 164.411 166.106 1.00 67.07  ? 255 GLU C OE1 1 
ATOM   3806 O OE2 . GLU C 3 232 ? 171.407 162.255 166.354 1.00 67.07  ? 255 GLU C OE2 1 
ATOM   3807 N N   . PRO C 3 233 ? 168.404 163.439 170.280 1.00 62.34  ? 256 PRO C N   1 
ATOM   3808 C CA  . PRO C 3 233 ? 167.575 163.140 171.456 1.00 62.34  ? 256 PRO C CA  1 
ATOM   3809 C C   . PRO C 3 233 ? 168.131 162.023 172.319 1.00 62.34  ? 256 PRO C C   1 
ATOM   3810 O O   . PRO C 3 233 ? 167.908 162.031 173.536 1.00 62.34  ? 256 PRO C O   1 
ATOM   3811 C CB  . PRO C 3 233 ? 166.223 162.760 170.839 1.00 62.34  ? 256 PRO C CB  1 
ATOM   3812 C CG  . PRO C 3 233 ? 166.573 162.221 169.495 1.00 62.34  ? 256 PRO C CG  1 
ATOM   3813 C CD  . PRO C 3 233 ? 167.768 163.006 169.024 1.00 62.34  ? 256 PRO C CD  1 
ATOM   3814 N N   . GLY C 3 234 ? 168.845 161.066 171.734 1.00 61.49  ? 257 GLY C N   1 
ATOM   3815 C CA  . GLY C 3 234 ? 169.392 159.964 172.500 1.00 61.49  ? 257 GLY C CA  1 
ATOM   3816 C C   . GLY C 3 234 ? 168.491 158.747 172.526 1.00 61.49  ? 257 GLY C C   1 
ATOM   3817 O O   . GLY C 3 234 ? 167.995 158.312 171.483 1.00 61.49  ? 257 GLY C O   1 
ATOM   3818 N N   . VAL C 3 235 ? 168.274 158.188 173.713 1.00 59.87  ? 258 VAL C N   1 
ATOM   3819 C CA  . VAL C 3 235 ? 167.456 156.993 173.888 1.00 59.87  ? 258 VAL C CA  1 
ATOM   3820 C C   . VAL C 3 235 ? 166.074 157.407 174.374 1.00 59.87  ? 258 VAL C C   1 
ATOM   3821 O O   . VAL C 3 235 ? 165.930 158.376 175.130 1.00 59.87  ? 258 VAL C O   1 
ATOM   3822 C CB  . VAL C 3 235 ? 168.125 156.003 174.864 1.00 59.87  ? 258 VAL C CB  1 
ATOM   3823 C CG1 . VAL C 3 235 ? 168.248 156.609 176.255 1.00 59.87  ? 258 VAL C CG1 1 
ATOM   3824 C CG2 . VAL C 3 235 ? 167.365 154.686 174.904 1.00 59.87  ? 258 VAL C CG2 1 
ATOM   3825 N N   . ASP C 3 236 ? 165.051 156.685 173.922 1.00 58.13  ? 259 ASP C N   1 
ATOM   3826 C CA  . ASP C 3 236 ? 163.679 156.971 174.317 1.00 58.13  ? 259 ASP C CA  1 
ATOM   3827 C C   . ASP C 3 236 ? 163.387 156.353 175.678 1.00 58.13  ? 259 ASP C C   1 
ATOM   3828 O O   . ASP C 3 236 ? 163.666 155.171 175.906 1.00 58.13  ? 259 ASP C O   1 
ATOM   3829 C CB  . ASP C 3 236 ? 162.705 156.435 173.269 1.00 58.13  ? 259 ASP C CB  1 
ATOM   3830 C CG  . ASP C 3 236 ? 161.301 156.976 173.446 1.00 58.13  ? 259 ASP C CG  1 
ATOM   3831 O OD1 . ASP C 3 236 ? 161.110 157.872 174.293 1.00 58.13  ? 259 ASP C OD1 1 
ATOM   3832 O OD2 . ASP C 3 236 ? 160.389 156.505 172.735 1.00 58.13  ? 259 ASP C OD2 1 
ATOM   3833 N N   . THR C 3 237 ? 162.823 157.151 176.582 1.00 52.17  ? 260 THR C N   1 
ATOM   3834 C CA  . THR C 3 237 ? 162.513 156.726 177.945 1.00 52.17  ? 260 THR C CA  1 
ATOM   3835 C C   . THR C 3 237 ? 161.043 156.975 178.256 1.00 52.17  ? 260 THR C C   1 
ATOM   3836 O O   . THR C 3 237 ? 160.684 157.515 179.304 1.00 52.17  ? 260 THR C O   1 
ATOM   3837 C CB  . THR C 3 237 ? 163.396 157.442 178.963 1.00 52.17  ? 260 THR C CB  1 
ATOM   3838 O OG1 . THR C 3 237 ? 163.197 158.857 178.859 1.00 52.17  ? 260 THR C OG1 1 
ATOM   3839 C CG2 . THR C 3 237 ? 164.862 157.122 178.719 1.00 52.17  ? 260 THR C CG2 1 
ATOM   3840 N N   . THR C 3 238 ? 160.168 156.578 177.337 1.00 49.55  ? 261 THR C N   1 
ATOM   3841 C CA  . THR C 3 238 ? 158.730 156.754 177.485 1.00 49.55  ? 261 THR C CA  1 
ATOM   3842 C C   . THR C 3 238 ? 158.065 155.394 177.651 1.00 49.55  ? 261 THR C C   1 
ATOM   3843 O O   . THR C 3 238 ? 158.291 154.485 176.845 1.00 49.55  ? 261 THR C O   1 
ATOM   3844 C CB  . THR C 3 238 ? 158.142 157.486 176.278 1.00 49.55  ? 261 THR C CB  1 
ATOM   3845 O OG1 . THR C 3 238 ? 158.758 158.773 176.152 1.00 49.55  ? 261 THR C OG1 1 
ATOM   3846 C CG2 . THR C 3 238 ? 156.642 157.665 176.441 1.00 49.55  ? 261 THR C CG2 1 
ATOM   3847 N N   . LEU C 3 239 ? 157.247 155.260 178.692 1.00 49.50  ? 262 LEU C N   1 
ATOM   3848 C CA  . LEU C 3 239 ? 156.538 154.021 178.964 1.00 49.50  ? 262 LEU C CA  1 
ATOM   3849 C C   . LEU C 3 239 ? 155.221 153.990 178.189 1.00 49.50  ? 262 LEU C C   1 
ATOM   3850 O O   . LEU C 3 239 ? 154.875 154.923 177.460 1.00 49.50  ? 262 LEU C O   1 
ATOM   3851 C CB  . LEU C 3 239 ? 156.310 153.859 180.465 1.00 49.50  ? 262 LEU C CB  1 
ATOM   3852 C CG  . LEU C 3 239 ? 157.579 153.861 181.320 1.00 49.50  ? 262 LEU C CG  1 
ATOM   3853 C CD1 . LEU C 3 239 ? 157.247 153.597 182.779 1.00 49.50  ? 262 LEU C CD1 1 
ATOM   3854 C CD2 . LEU C 3 239 ? 158.577 152.840 180.802 1.00 49.50  ? 262 LEU C CD2 1 
ATOM   3855 N N   . THR C 3 240 ? 154.469 152.901 178.349 1.00 49.66  ? 263 THR C N   1 
ATOM   3856 C CA  . THR C 3 240 ? 153.261 152.676 177.564 1.00 49.66  ? 263 THR C CA  1 
ATOM   3857 C C   . THR C 3 240 ? 151.979 153.048 178.296 1.00 49.66  ? 263 THR C C   1 
ATOM   3858 O O   . THR C 3 240 ? 151.068 153.609 177.681 1.00 49.66  ? 263 THR C O   1 
ATOM   3859 C CB  . THR C 3 240 ? 153.183 151.211 177.119 1.00 49.66  ? 263 THR C CB  1 
ATOM   3860 O OG1 . THR C 3 240 ? 151.881 150.944 176.584 1.00 49.66  ? 263 THR C OG1 1 
ATOM   3861 C CG2 . THR C 3 240 ? 153.451 150.278 178.286 1.00 49.66  ? 263 THR C CG2 1 
ATOM   3862 N N   . TRP C 3 241 ? 151.878 152.756 179.588 1.00 48.10  ? 264 TRP C N   1 
ATOM   3863 C CA  . TRP C 3 241 ? 150.675 153.074 180.345 1.00 48.10  ? 264 TRP C CA  1 
ATOM   3864 C C   . TRP C 3 241 ? 150.697 154.554 180.725 1.00 48.10  ? 264 TRP C C   1 
ATOM   3865 O O   . TRP C 3 241 ? 151.492 155.344 180.210 1.00 48.10  ? 264 TRP C O   1 
ATOM   3866 C CB  . TRP C 3 241 ? 150.556 152.162 181.563 1.00 48.10  ? 264 TRP C CB  1 
ATOM   3867 C CG  . TRP C 3 241 ? 150.316 150.721 181.217 1.00 48.10  ? 264 TRP C CG  1 
ATOM   3868 C CD1 . TRP C 3 241 ? 151.262 149.769 180.976 1.00 48.10  ? 264 TRP C CD1 1 
ATOM   3869 C CD2 . TRP C 3 241 ? 149.047 150.066 181.079 1.00 48.10  ? 264 TRP C CD2 1 
ATOM   3870 N NE1 . TRP C 3 241 ? 150.664 148.566 180.693 1.00 48.10  ? 264 TRP C NE1 1 
ATOM   3871 C CE2 . TRP C 3 241 ? 149.304 148.721 180.750 1.00 48.10  ? 264 TRP C CE2 1 
ATOM   3872 C CE3 . TRP C 3 241 ? 147.720 150.487 181.201 1.00 48.10  ? 264 TRP C CE3 1 
ATOM   3873 C CZ2 . TRP C 3 241 ? 148.285 147.796 180.542 1.00 48.10  ? 264 TRP C CZ2 1 
ATOM   3874 C CZ3 . TRP C 3 241 ? 146.709 149.565 180.993 1.00 48.10  ? 264 TRP C CZ3 1 
ATOM   3875 C CH2 . TRP C 3 241 ? 146.998 148.236 180.667 1.00 48.10  ? 264 TRP C CH2 1 
ATOM   3876 N N   . ARG C 3 242 ? 149.815 154.948 181.640 1.00 50.32  ? 265 ARG C N   1 
ATOM   3877 C CA  . ARG C 3 242 ? 149.688 156.338 182.057 1.00 50.32  ? 265 ARG C CA  1 
ATOM   3878 C C   . ARG C 3 242 ? 150.762 156.767 183.053 1.00 50.32  ? 265 ARG C C   1 
ATOM   3879 O O   . ARG C 3 242 ? 150.607 157.811 183.697 1.00 50.32  ? 265 ARG C O   1 
ATOM   3880 C CB  . ARG C 3 242 ? 148.299 156.576 182.656 1.00 50.32  ? 265 ARG C CB  1 
ATOM   3881 C CG  . ARG C 3 242 ? 147.193 156.710 181.625 1.00 50.32  ? 265 ARG C CG  1 
ATOM   3882 C CD  . ARG C 3 242 ? 146.827 158.166 181.399 1.00 50.32  ? 265 ARG C CD  1 
ATOM   3883 N NE  . ARG C 3 242 ? 145.910 158.333 180.277 1.00 50.32  ? 265 ARG C NE  1 
ATOM   3884 C CZ  . ARG C 3 242 ? 145.335 159.485 179.949 1.00 50.32  ? 265 ARG C CZ  1 
ATOM   3885 N NH1 . ARG C 3 242 ? 145.580 160.576 180.661 1.00 50.32  ? 265 ARG C NH1 1 
ATOM   3886 N NH2 . ARG C 3 242 ? 144.515 159.548 178.909 1.00 50.32  ? 265 ARG C NH2 1 
ATOM   3887 N N   . LYS C 3 243 ? 151.842 155.997 183.196 1.00 49.01  ? 266 LYS C N   1 
ATOM   3888 C CA  . LYS C 3 243 ? 152.862 156.317 184.190 1.00 49.01  ? 266 LYS C CA  1 
ATOM   3889 C C   . LYS C 3 243 ? 153.778 157.438 183.711 1.00 49.01  ? 266 LYS C C   1 
ATOM   3890 O O   . LYS C 3 243 ? 153.849 158.504 184.330 1.00 49.01  ? 266 LYS C O   1 
ATOM   3891 C CB  . LYS C 3 243 ? 153.671 155.064 184.531 1.00 49.01  ? 266 LYS C CB  1 
ATOM   3892 C CG  . LYS C 3 243 ? 152.841 153.949 185.140 1.00 49.01  ? 266 LYS C CG  1 
ATOM   3893 C CD  . LYS C 3 243 ? 151.995 154.466 186.291 1.00 49.01  ? 266 LYS C CD  1 
ATOM   3894 C CE  . LYS C 3 243 ? 150.984 153.430 186.744 1.00 49.01  ? 266 LYS C CE  1 
ATOM   3895 N NZ  . LYS C 3 243 ? 150.088 153.960 187.808 1.00 49.01  ? 266 LYS C NZ  1 
ATOM   3896 N N   . GLN C 3 244 ? 154.489 157.213 182.608 1.00 53.65  ? 267 GLN C N   1 
ATOM   3897 C CA  . GLN C 3 244 ? 155.416 158.195 182.058 1.00 53.65  ? 267 GLN C CA  1 
ATOM   3898 C C   . GLN C 3 244 ? 155.108 158.378 180.581 1.00 53.65  ? 267 GLN C C   1 
ATOM   3899 O O   . GLN C 3 244 ? 155.248 157.436 179.795 1.00 53.65  ? 267 GLN C O   1 
ATOM   3900 C CB  . GLN C 3 244 ? 156.868 157.756 182.258 1.00 53.65  ? 267 GLN C CB  1 
ATOM   3901 C CG  . GLN C 3 244 ? 157.894 158.770 181.791 1.00 53.65  ? 267 GLN C CG  1 
ATOM   3902 C CD  . GLN C 3 244 ? 159.301 158.406 182.216 1.00 53.65  ? 267 GLN C CD  1 
ATOM   3903 O OE1 . GLN C 3 244 ? 159.503 157.491 183.014 1.00 53.65  ? 267 GLN C OE1 1 
ATOM   3904 N NE2 . GLN C 3 244 ? 160.284 159.122 181.683 1.00 53.65  ? 267 GLN C NE2 1 
ATOM   3905 N N   . ARG C 3 245 ? 154.692 159.582 180.208 1.00 53.73  ? 268 ARG C N   1 
ATOM   3906 C CA  . ARG C 3 245 ? 154.289 159.876 178.839 1.00 53.73  ? 268 ARG C CA  1 
ATOM   3907 C C   . ARG C 3 245 ? 155.153 160.925 178.162 1.00 53.73  ? 268 ARG C C   1 
ATOM   3908 O O   . ARG C 3 245 ? 155.536 160.746 177.003 1.00 53.73  ? 268 ARG C O   1 
ATOM   3909 C CB  . ARG C 3 245 ? 152.827 160.343 178.806 1.00 53.73  ? 268 ARG C CB  1 
ATOM   3910 C CG  . ARG C 3 245 ? 151.832 159.349 179.369 1.00 53.73  ? 268 ARG C CG  1 
ATOM   3911 C CD  . ARG C 3 245 ? 150.487 160.012 179.604 1.00 53.73  ? 268 ARG C CD  1 
ATOM   3912 N NE  . ARG C 3 245 ? 150.016 160.719 178.417 1.00 53.73  ? 268 ARG C NE  1 
ATOM   3913 C CZ  . ARG C 3 245 ? 148.969 161.537 178.399 1.00 53.73  ? 268 ARG C CZ  1 
ATOM   3914 N NH1 . ARG C 3 245 ? 148.278 161.756 179.509 1.00 53.73  ? 268 ARG C NH1 1 
ATOM   3915 N NH2 . ARG C 3 245 ? 148.613 162.138 177.272 1.00 53.73  ? 268 ARG C NH2 1 
ATOM   3916 N N   . PHE C 3 246 ? 155.472 162.017 178.849 1.00 54.35  ? 269 PHE C N   1 
ATOM   3917 C CA  . PHE C 3 246 ? 156.115 163.165 178.231 1.00 54.35  ? 269 PHE C CA  1 
ATOM   3918 C C   . PHE C 3 246 ? 157.614 163.166 178.497 1.00 54.35  ? 269 PHE C C   1 
ATOM   3919 O O   . PHE C 3 246 ? 158.067 162.793 179.583 1.00 54.35  ? 269 PHE C O   1 
ATOM   3920 C CB  . PHE C 3 246 ? 155.501 164.469 178.742 1.00 54.35  ? 269 PHE C CB  1 
ATOM   3921 C CG  . PHE C 3 246 ? 154.026 164.583 178.490 1.00 54.35  ? 269 PHE C CG  1 
ATOM   3922 C CD1 . PHE C 3 246 ? 153.544 164.800 177.211 1.00 54.35  ? 269 PHE C CD1 1 
ATOM   3923 C CD2 . PHE C 3 246 ? 153.123 164.482 179.534 1.00 54.35  ? 269 PHE C CD2 1 
ATOM   3924 C CE1 . PHE C 3 246 ? 152.188 164.907 176.976 1.00 54.35  ? 269 PHE C CE1 1 
ATOM   3925 C CE2 . PHE C 3 246 ? 151.766 164.590 179.305 1.00 54.35  ? 269 PHE C CE2 1 
ATOM   3926 C CZ  . PHE C 3 246 ? 151.297 164.802 178.025 1.00 54.35  ? 269 PHE C CZ  1 
ATOM   3927 N N   . GLN C 3 247 ? 158.376 163.591 177.489 1.00 56.81  ? 270 GLN C N   1 
ATOM   3928 C CA  . GLN C 3 247 ? 159.820 163.808 177.586 1.00 56.81  ? 270 GLN C CA  1 
ATOM   3929 C C   . GLN C 3 247 ? 160.077 165.170 176.948 1.00 56.81  ? 270 GLN C C   1 
ATOM   3930 O O   . GLN C 3 247 ? 160.315 165.265 175.741 1.00 56.81  ? 270 GLN C O   1 
ATOM   3931 C CB  . GLN C 3 247 ? 160.600 162.692 176.900 1.00 56.81  ? 270 GLN C CB  1 
ATOM   3932 C CG  . GLN C 3 247 ? 162.106 162.805 177.039 1.00 56.81  ? 270 GLN C CG  1 
ATOM   3933 C CD  . GLN C 3 247 ? 162.840 161.728 176.267 1.00 56.81  ? 270 GLN C CD  1 
ATOM   3934 O OE1 . GLN C 3 247 ? 162.230 160.947 175.538 1.00 56.81  ? 270 GLN C OE1 1 
ATOM   3935 N NE2 . GLN C 3 247 ? 164.157 161.681 176.423 1.00 56.81  ? 270 GLN C NE2 1 
ATOM   3936 N N   . ASN C 3 248 ? 160.027 166.221 177.760 1.00 59.29  ? 271 ASN C N   1 
ATOM   3937 C CA  . ASN C 3 248 ? 160.024 167.581 177.243 1.00 59.29  ? 271 ASN C CA  1 
ATOM   3938 C C   . ASN C 3 248 ? 161.438 168.084 176.974 1.00 59.29  ? 271 ASN C C   1 
ATOM   3939 O O   . ASN C 3 248 ? 162.400 167.695 177.641 1.00 59.29  ? 271 ASN C O   1 
ATOM   3940 C CB  . ASN C 3 248 ? 159.321 168.519 178.223 1.00 59.29  ? 271 ASN C CB  1 
ATOM   3941 C CG  . ASN C 3 248 ? 157.858 168.179 178.402 1.00 59.29  ? 271 ASN C CG  1 
ATOM   3942 O OD1 . ASN C 3 248 ? 157.241 167.572 177.527 1.00 59.29  ? 271 ASN C OD1 1 
ATOM   3943 N ND2 . ASN C 3 248 ? 157.292 168.570 179.538 1.00 59.29  ? 271 ASN C ND2 1 
ATOM   3944 N N   . TYR C 3 249 ? 161.549 168.963 175.980 1.00 58.20  ? 272 TYR C N   1 
ATOM   3945 C CA  . TYR C 3 249 ? 162.799 169.627 175.632 1.00 58.20  ? 272 TYR C CA  1 
ATOM   3946 C C   . TYR C 3 249 ? 162.558 171.129 175.633 1.00 58.20  ? 272 TYR C C   1 
ATOM   3947 O O   . TYR C 3 249 ? 161.847 171.645 174.765 1.00 58.20  ? 272 TYR C O   1 
ATOM   3948 C CB  . TYR C 3 249 ? 163.310 169.164 174.266 1.00 58.20  ? 272 TYR C CB  1 
ATOM   3949 C CG  . TYR C 3 249 ? 164.004 167.821 174.287 1.00 58.20  ? 272 TYR C CG  1 
ATOM   3950 C CD1 . TYR C 3 249 ? 165.385 167.733 174.404 1.00 58.20  ? 272 TYR C CD1 1 
ATOM   3951 C CD2 . TYR C 3 249 ? 163.281 166.641 174.184 1.00 58.20  ? 272 TYR C CD2 1 
ATOM   3952 C CE1 . TYR C 3 249 ? 166.024 166.509 174.422 1.00 58.20  ? 272 TYR C CE1 1 
ATOM   3953 C CE2 . TYR C 3 249 ? 163.911 165.413 174.201 1.00 58.20  ? 272 TYR C CE2 1 
ATOM   3954 C CZ  . TYR C 3 249 ? 165.283 165.353 174.321 1.00 58.20  ? 272 TYR C CZ  1 
ATOM   3955 O OH  . TYR C 3 249 ? 165.916 164.132 174.338 1.00 58.20  ? 272 TYR C OH  1 
ATOM   3956 N N   . THR C 3 250 ? 163.146 171.824 176.601 1.00 62.00  ? 273 THR C N   1 
ATOM   3957 C CA  . THR C 3 250 ? 162.939 173.255 176.784 1.00 62.00  ? 273 THR C CA  1 
ATOM   3958 C C   . THR C 3 250 ? 164.226 174.007 176.474 1.00 62.00  ? 273 THR C C   1 
ATOM   3959 O O   . THR C 3 250 ? 165.291 173.669 177.002 1.00 62.00  ? 273 THR C O   1 
ATOM   3960 C CB  . THR C 3 250 ? 162.479 173.563 178.210 1.00 62.00  ? 273 THR C CB  1 
ATOM   3961 O OG1 . THR C 3 250 ? 161.213 172.936 178.452 1.00 62.00  ? 273 THR C OG1 1 
ATOM   3962 C CG2 . THR C 3 250 ? 162.340 175.061 178.415 1.00 62.00  ? 273 THR C CG2 1 
ATOM   3963 N N   . LEU C 3 251 ? 164.122 175.027 175.624 1.00 64.82  ? 274 LEU C N   1 
ATOM   3964 C CA  . LEU C 3 251 ? 165.251 175.865 175.231 1.00 64.82  ? 274 LEU C CA  1 
ATOM   3965 C C   . LEU C 3 251 ? 164.968 177.290 175.688 1.00 64.82  ? 274 LEU C C   1 
ATOM   3966 O O   . LEU C 3 251 ? 164.056 177.942 175.169 1.00 64.82  ? 274 LEU C O   1 
ATOM   3967 C CB  . LEU C 3 251 ? 165.471 175.804 173.720 1.00 64.82  ? 274 LEU C CB  1 
ATOM   3968 C CG  . LEU C 3 251 ? 166.620 176.635 173.150 1.00 64.82  ? 274 LEU C CG  1 
ATOM   3969 C CD1 . LEU C 3 251 ? 167.958 176.084 173.610 1.00 64.82  ? 274 LEU C CD1 1 
ATOM   3970 C CD2 . LEU C 3 251 ? 166.548 176.674 171.632 1.00 64.82  ? 274 LEU C CD2 1 
ATOM   3971 N N   . CYS C 3 252 ? 165.749 177.776 176.652 1.00 71.60  ? 275 CYS C N   1 
ATOM   3972 C CA  . CYS C 3 252 ? 165.529 179.089 177.254 1.00 71.60  ? 275 CYS C CA  1 
ATOM   3973 C C   . CYS C 3 252 ? 166.784 179.936 177.102 1.00 71.60  ? 275 CYS C C   1 
ATOM   3974 O O   . CYS C 3 252 ? 167.848 179.577 177.616 1.00 71.60  ? 275 CYS C O   1 
ATOM   3975 C CB  . CYS C 3 252 ? 165.130 178.960 178.726 1.00 71.60  ? 275 CYS C CB  1 
ATOM   3976 S SG  . CYS C 3 252 ? 164.077 180.305 179.345 1.00 71.60  ? 275 CYS C SG  1 
ATOM   3977 N N   . GLU C 3 253 ? 166.654 181.057 176.399 1.00 76.23  ? 276 GLU C N   1 
ATOM   3978 C CA  . GLU C 3 253 ? 167.743 182.005 176.236 1.00 76.23  ? 276 GLU C CA  1 
ATOM   3979 C C   . GLU C 3 253 ? 167.843 182.909 177.463 1.00 76.23  ? 276 GLU C C   1 
ATOM   3980 O O   . GLU C 3 253 ? 166.874 183.111 178.200 1.00 76.23  ? 276 GLU C O   1 
ATOM   3981 C CB  . GLU C 3 253 ? 167.537 182.838 174.970 1.00 76.23  ? 276 GLU C CB  1 
ATOM   3982 C CG  . GLU C 3 253 ? 168.811 183.408 174.375 1.00 76.23  ? 276 GLU C CG  1 
ATOM   3983 C CD  . GLU C 3 253 ? 169.064 184.833 174.813 1.00 76.23  ? 276 GLU C CD  1 
ATOM   3984 O OE1 . GLU C 3 253 ? 168.185 185.410 175.484 1.00 76.23  ? 276 GLU C OE1 1 
ATOM   3985 O OE2 . GLU C 3 253 ? 170.140 185.376 174.489 1.00 76.23  ? 276 GLU C OE2 1 
ATOM   3986 N N   . SER C 3 254 ? 169.039 183.455 177.679 1.00 77.23  ? 277 SER C N   1 
ATOM   3987 C CA  . SER C 3 254 ? 169.311 184.235 178.880 1.00 77.23  ? 277 SER C CA  1 
ATOM   3988 C C   . SER C 3 254 ? 168.994 185.717 178.701 1.00 77.23  ? 277 SER C C   1 
ATOM   3989 O O   . SER C 3 254 ? 168.341 186.321 179.558 1.00 77.23  ? 277 SER C O   1 
ATOM   3990 C CB  . SER C 3 254 ? 170.774 184.059 179.299 1.00 77.23  ? 277 SER C CB  1 
ATOM   3991 O OG  . SER C 3 254 ? 171.604 185.011 178.658 1.00 77.23  ? 277 SER C OG  1 
ATOM   3992 N N   . PHE C 3 255 ? 169.450 186.319 177.600 1.00 81.65  ? 278 PHE C N   1 
ATOM   3993 C CA  . PHE C 3 255 ? 169.271 187.753 177.406 1.00 81.65  ? 278 PHE C CA  1 
ATOM   3994 C C   . PHE C 3 255 ? 167.828 188.133 177.096 1.00 81.65  ? 278 PHE C C   1 
ATOM   3995 O O   . PHE C 3 255 ? 167.487 189.318 177.164 1.00 81.65  ? 278 PHE C O   1 
ATOM   3996 C CB  . PHE C 3 255 ? 170.184 188.252 176.284 1.00 81.65  ? 278 PHE C CB  1 
ATOM   3997 C CG  . PHE C 3 255 ? 171.644 188.215 176.630 1.00 81.65  ? 278 PHE C CG  1 
ATOM   3998 C CD1 . PHE C 3 255 ? 172.246 189.290 177.261 1.00 81.65  ? 278 PHE C CD1 1 
ATOM   3999 C CD2 . PHE C 3 255 ? 172.417 187.110 176.317 1.00 81.65  ? 278 PHE C CD2 1 
ATOM   4000 C CE1 . PHE C 3 255 ? 173.590 189.262 177.580 1.00 81.65  ? 278 PHE C CE1 1 
ATOM   4001 C CE2 . PHE C 3 255 ? 173.763 187.076 176.633 1.00 81.65  ? 278 PHE C CE2 1 
ATOM   4002 C CZ  . PHE C 3 255 ? 174.349 188.153 177.266 1.00 81.65  ? 278 PHE C CZ  1 
ATOM   4003 N N   . SER C 3 256 ? 166.975 187.164 176.756 1.00 80.72  ? 279 SER C N   1 
ATOM   4004 C CA  . SER C 3 256 ? 165.589 187.445 176.412 1.00 80.72  ? 279 SER C CA  1 
ATOM   4005 C C   . SER C 3 256 ? 164.572 186.810 177.348 1.00 80.72  ? 279 SER C C   1 
ATOM   4006 O O   . SER C 3 256 ? 163.431 187.281 177.391 1.00 80.72  ? 279 SER C O   1 
ATOM   4007 C CB  . SER C 3 256 ? 165.286 186.983 174.978 1.00 80.72  ? 279 SER C CB  1 
ATOM   4008 O OG  . SER C 3 256 ? 163.895 186.796 174.788 1.00 80.72  ? 279 SER C OG  1 
ATOM   4009 N N   . LYS C 3 257 ? 164.946 185.764 178.089 1.00 80.17  ? 280 LYS C N   1 
ATOM   4010 C CA  . LYS C 3 257 ? 164.050 185.073 179.016 1.00 80.17  ? 280 LYS C CA  1 
ATOM   4011 C C   . LYS C 3 257 ? 162.803 184.557 178.293 1.00 80.17  ? 280 LYS C C   1 
ATOM   4012 O O   . LYS C 3 257 ? 161.670 184.945 178.587 1.00 80.17  ? 280 LYS C O   1 
ATOM   4013 C CB  . LYS C 3 257 ? 163.670 185.977 180.196 1.00 80.17  ? 280 LYS C CB  1 
ATOM   4014 C CG  . LYS C 3 257 ? 164.815 186.291 181.146 1.00 80.17  ? 280 LYS C CG  1 
ATOM   4015 C CD  . LYS C 3 257 ? 165.502 187.597 180.777 1.00 80.17  ? 280 LYS C CD  1 
ATOM   4016 C CE  . LYS C 3 257 ? 166.544 187.983 181.814 1.00 80.17  ? 280 LYS C CE  1 
ATOM   4017 N NZ  . LYS C 3 257 ? 167.160 189.303 181.512 1.00 80.17  ? 280 LYS C NZ  1 
ATOM   4018 N N   . ARG C 3 258 ? 163.035 183.665 177.333 1.00 76.98  ? 281 ARG C N   1 
ATOM   4019 C CA  . ARG C 3 258 ? 161.970 183.063 176.545 1.00 76.98  ? 281 ARG C CA  1 
ATOM   4020 C C   . ARG C 3 258 ? 162.217 181.568 176.426 1.00 76.98  ? 281 ARG C C   1 
ATOM   4021 O O   . ARG C 3 258 ? 163.320 181.148 176.062 1.00 76.98  ? 281 ARG C O   1 
ATOM   4022 C CB  . ARG C 3 258 ? 161.887 183.688 175.149 1.00 76.98  ? 281 ARG C CB  1 
ATOM   4023 C CG  . ARG C 3 258 ? 161.143 185.008 175.086 1.00 76.98  ? 281 ARG C CG  1 
ATOM   4024 C CD  . ARG C 3 258 ? 160.960 185.437 173.641 1.00 76.98  ? 281 ARG C CD  1 
ATOM   4025 N NE  . ARG C 3 258 ? 160.402 184.358 172.832 1.00 76.98  ? 281 ARG C NE  1 
ATOM   4026 C CZ  . ARG C 3 258 ? 160.345 184.369 171.504 1.00 76.98  ? 281 ARG C CZ  1 
ATOM   4027 N NH1 . ARG C 3 258 ? 160.816 185.406 170.826 1.00 76.98  ? 281 ARG C NH1 1 
ATOM   4028 N NH2 . ARG C 3 258 ? 159.818 183.341 170.854 1.00 76.98  ? 281 ARG C NH2 1 
ATOM   4029 N N   . CYS C 3 259 ? 161.193 180.772 176.722 1.00 74.64  ? 282 CYS C N   1 
ATOM   4030 C CA  . CYS C 3 259 ? 161.284 179.327 176.571 1.00 74.64  ? 282 CYS C CA  1 
ATOM   4031 C C   . CYS C 3 259 ? 159.888 178.730 176.588 1.00 74.64  ? 282 CYS C C   1 
ATOM   4032 O O   . CYS C 3 259 ? 159.072 179.069 177.449 1.00 74.64  ? 282 CYS C O   1 
ATOM   4033 C CB  . CYS C 3 259 ? 162.139 178.692 177.675 1.00 74.64  ? 282 CYS C CB  1 
ATOM   4034 S SG  . CYS C 3 259 ? 162.180 179.580 179.244 1.00 74.64  ? 282 CYS C SG  1 
ATOM   4035 N N   . GLU C 3 260 ? 159.626 177.841 175.633 1.00 72.87  ? 283 GLU C N   1 
ATOM   4036 C CA  . GLU C 3 260 ? 158.381 177.093 175.577 1.00 72.87  ? 283 GLU C CA  1 
ATOM   4037 C C   . GLU C 3 260 ? 158.696 175.651 175.211 1.00 72.87  ? 283 GLU C C   1 
ATOM   4038 O O   . GLU C 3 260 ? 159.741 175.351 174.628 1.00 72.87  ? 283 GLU C O   1 
ATOM   4039 C CB  . GLU C 3 260 ? 157.391 177.694 174.567 1.00 72.87  ? 283 GLU C CB  1 
ATOM   4040 C CG  . GLU C 3 260 ? 157.945 177.884 173.159 1.00 72.87  ? 283 GLU C CG  1 
ATOM   4041 C CD  . GLU C 3 260 ? 158.661 179.211 172.973 1.00 72.87  ? 283 GLU C CD  1 
ATOM   4042 O OE1 . GLU C 3 260 ? 159.656 179.458 173.684 1.00 72.87  ? 283 GLU C OE1 1 
ATOM   4043 O OE2 . GLU C 3 260 ? 158.228 180.006 172.112 1.00 72.87  ? 283 GLU C OE2 1 
ATOM   4044 N N   . VAL C 3 261 ? 157.776 174.754 175.563 1.00 68.97  ? 284 VAL C N   1 
ATOM   4045 C CA  . VAL C 3 261 ? 157.965 173.339 175.276 1.00 68.97  ? 284 VAL C CA  1 
ATOM   4046 C C   . VAL C 3 261 ? 157.881 173.113 173.773 1.00 68.97  ? 284 VAL C C   1 
ATOM   4047 O O   . VAL C 3 261 ? 156.877 173.447 173.132 1.00 68.97  ? 284 VAL C O   1 
ATOM   4048 C CB  . VAL C 3 261 ? 156.927 172.492 176.025 1.00 68.97  ? 284 VAL C CB  1 
ATOM   4049 C CG1 . VAL C 3 261 ? 157.064 171.027 175.641 1.00 68.97  ? 284 VAL C CG1 1 
ATOM   4050 C CG2 . VAL C 3 261 ? 157.080 172.675 177.527 1.00 68.97  ? 284 VAL C CG2 1 
ATOM   4051 N N   . SER C 3 262 ? 158.939 172.545 173.204 1.00 69.50  ? 285 SER C N   1 
ATOM   4052 C CA  . SER C 3 262 ? 158.973 172.273 171.777 1.00 69.50  ? 285 SER C CA  1 
ATOM   4053 C C   . SER C 3 262 ? 158.073 171.092 171.434 1.00 69.50  ? 285 SER C C   1 
ATOM   4054 O O   . SER C 3 262 ? 157.915 170.153 172.219 1.00 69.50  ? 285 SER C O   1 
ATOM   4055 C CB  . SER C 3 262 ? 160.403 171.988 171.318 1.00 69.50  ? 285 SER C CB  1 
ATOM   4056 O OG  . SER C 3 262 ? 160.410 171.254 170.107 1.00 69.50  ? 285 SER C OG  1 
ATOM   4057 N N   . ASN C 3 263 ? 157.478 171.150 170.245 1.00 73.03  ? 286 ASN C N   1 
ATOM   4058 C CA  . ASN C 3 263 ? 156.590 170.096 169.777 1.00 73.03  ? 286 ASN C CA  1 
ATOM   4059 C C   . ASN C 3 263 ? 157.330 168.936 169.127 1.00 73.03  ? 286 ASN C C   1 
ATOM   4060 O O   . ASN C 3 263 ? 156.725 167.881 168.908 1.00 73.03  ? 286 ASN C O   1 
ATOM   4061 C CB  . ASN C 3 263 ? 155.569 170.665 168.787 1.00 73.03  ? 286 ASN C CB  1 
ATOM   4062 C CG  . ASN C 3 263 ? 154.470 171.450 169.473 1.00 73.03  ? 286 ASN C CG  1 
ATOM   4063 O OD1 . ASN C 3 263 ? 153.832 172.309 168.864 1.00 73.03  ? 286 ASN C OD1 1 
ATOM   4064 N ND2 . ASN C 3 263 ? 154.243 171.160 170.749 1.00 73.03  ? 286 ASN C ND2 1 
ATOM   4065 N N   . TYR C 3 264 ? 158.610 169.101 168.815 1.00 71.17  ? 287 TYR C N   1 
ATOM   4066 C CA  . TYR C 3 264 ? 159.417 168.057 168.203 1.00 71.17  ? 287 TYR C CA  1 
ATOM   4067 C C   . TYR C 3 264 ? 160.446 167.541 169.200 1.00 71.17  ? 287 TYR C C   1 
ATOM   4068 O O   . TYR C 3 264 ? 160.622 168.084 170.293 1.00 71.17  ? 287 TYR C O   1 
ATOM   4069 C CB  . TYR C 3 264 ? 160.105 168.575 166.936 1.00 71.17  ? 287 TYR C CB  1 
ATOM   4070 C CG  . TYR C 3 264 ? 159.147 168.875 165.808 1.00 71.17  ? 287 TYR C CG  1 
ATOM   4071 C CD1 . TYR C 3 264 ? 158.793 167.893 164.893 1.00 71.17  ? 287 TYR C CD1 1 
ATOM   4072 C CD2 . TYR C 3 264 ? 158.592 170.139 165.660 1.00 71.17  ? 287 TYR C CD2 1 
ATOM   4073 C CE1 . TYR C 3 264 ? 157.916 168.161 163.860 1.00 71.17  ? 287 TYR C CE1 1 
ATOM   4074 C CE2 . TYR C 3 264 ? 157.714 170.417 164.631 1.00 71.17  ? 287 TYR C CE2 1 
ATOM   4075 C CZ  . TYR C 3 264 ? 157.379 169.425 163.734 1.00 71.17  ? 287 TYR C CZ  1 
ATOM   4076 O OH  . TYR C 3 264 ? 156.505 169.698 162.708 1.00 71.17  ? 287 TYR C OH  1 
ATOM   4077 N N   . ARG C 3 265 ? 161.133 166.471 168.804 1.00 64.60  ? 288 ARG C N   1 
ATOM   4078 C CA  . ARG C 3 265 ? 162.110 165.811 169.661 1.00 64.60  ? 288 ARG C CA  1 
ATOM   4079 C C   . ARG C 3 265 ? 163.544 166.225 169.365 1.00 64.60  ? 288 ARG C C   1 
ATOM   4080 O O   . ARG C 3 265 ? 164.351 166.342 170.293 1.00 64.60  ? 288 ARG C O   1 
ATOM   4081 C CB  . ARG C 3 265 ? 161.983 164.290 169.527 1.00 64.60  ? 288 ARG C CB  1 
ATOM   4082 C CG  . ARG C 3 265 ? 162.292 163.527 170.803 1.00 64.60  ? 288 ARG C CG  1 
ATOM   4083 C CD  . ARG C 3 265 ? 161.983 162.047 170.647 1.00 64.60  ? 288 ARG C CD  1 
ATOM   4084 N NE  . ARG C 3 265 ? 161.828 161.383 171.938 1.00 64.60  ? 288 ARG C NE  1 
ATOM   4085 C CZ  . ARG C 3 265 ? 160.682 161.311 172.607 1.00 64.60  ? 288 ARG C CZ  1 
ATOM   4086 N NH1 . ARG C 3 265 ? 160.633 160.686 173.775 1.00 64.60  ? 288 ARG C NH1 1 
ATOM   4087 N NH2 . ARG C 3 265 ? 159.585 161.864 172.109 1.00 64.60  ? 288 ARG C NH2 1 
ATOM   4088 N N   . ASN C 3 266 ? 163.886 166.451 168.096 1.00 66.62  ? 289 ASN C N   1 
ATOM   4089 C CA  . ASN C 3 266 ? 165.252 166.784 167.709 1.00 66.62  ? 289 ASN C CA  1 
ATOM   4090 C C   . ASN C 3 266 ? 165.295 167.992 166.781 1.00 66.62  ? 289 ASN C C   1 
ATOM   4091 O O   . ASN C 3 266 ? 166.211 168.119 165.964 1.00 66.62  ? 289 ASN C O   1 
ATOM   4092 C CB  . ASN C 3 266 ? 165.938 165.585 167.054 1.00 66.62  ? 289 ASN C CB  1 
ATOM   4093 C CG  . ASN C 3 266 ? 165.088 164.946 165.974 1.00 66.62  ? 289 ASN C CG  1 
ATOM   4094 O OD1 . ASN C 3 266 ? 164.094 165.519 165.528 1.00 66.62  ? 289 ASN C OD1 1 
ATOM   4095 N ND2 . ASN C 3 266 ? 165.476 163.750 165.547 1.00 66.62  ? 289 ASN C ND2 1 
ATOM   4096 N N   . SER C 3 267 ? 164.318 168.888 166.892 1.00 67.94  ? 290 SER C N   1 
ATOM   4097 C CA  . SER C 3 267 ? 164.282 170.074 166.048 1.00 67.94  ? 290 SER C CA  1 
ATOM   4098 C C   . SER C 3 267 ? 163.385 171.117 166.695 1.00 67.94  ? 290 SER C C   1 
ATOM   4099 O O   . SER C 3 267 ? 162.498 170.794 167.489 1.00 67.94  ? 290 SER C O   1 
ATOM   4100 C CB  . SER C 3 267 ? 163.791 169.744 164.635 1.00 67.94  ? 290 SER C CB  1 
ATOM   4101 O OG  . SER C 3 267 ? 163.368 170.914 163.957 1.00 67.94  ? 290 SER C OG  1 
ATOM   4102 N N   . TYR C 3 268 ? 163.628 172.376 166.336 1.00 68.92  ? 291 TYR C N   1 
ATOM   4103 C CA  . TYR C 3 268 ? 162.844 173.497 166.836 1.00 68.92  ? 291 TYR C CA  1 
ATOM   4104 C C   . TYR C 3 268 ? 163.157 174.723 165.994 1.00 68.92  ? 291 TYR C C   1 
ATOM   4105 O O   . TYR C 3 268 ? 164.314 174.950 165.632 1.00 68.92  ? 291 TYR C O   1 
ATOM   4106 C CB  . TYR C 3 268 ? 163.146 173.776 168.314 1.00 68.92  ? 291 TYR C CB  1 
ATOM   4107 C CG  . TYR C 3 268 ? 162.362 174.930 168.894 1.00 68.92  ? 291 TYR C CG  1 
ATOM   4108 C CD1 . TYR C 3 268 ? 162.969 176.153 169.142 1.00 68.92  ? 291 TYR C CD1 1 
ATOM   4109 C CD2 . TYR C 3 268 ? 161.013 174.796 169.193 1.00 68.92  ? 291 TYR C CD2 1 
ATOM   4110 C CE1 . TYR C 3 268 ? 162.255 177.209 169.673 1.00 68.92  ? 291 TYR C CE1 1 
ATOM   4111 C CE2 . TYR C 3 268 ? 160.291 175.847 169.724 1.00 68.92  ? 291 TYR C CE2 1 
ATOM   4112 C CZ  . TYR C 3 268 ? 160.918 177.051 169.962 1.00 68.92  ? 291 TYR C CZ  1 
ATOM   4113 O OH  . TYR C 3 268 ? 160.203 178.101 170.490 1.00 68.92  ? 291 TYR C OH  1 
ATOM   4114 N N   . THR C 3 269 ? 162.125 175.505 165.690 1.00 69.90  ? 292 THR C N   1 
ATOM   4115 C CA  . THR C 3 269 ? 162.252 176.716 164.881 1.00 69.90  ? 292 THR C CA  1 
ATOM   4116 C C   . THR C 3 269 ? 162.043 177.919 165.795 1.00 69.90  ? 292 THR C C   1 
ATOM   4117 O O   . THR C 3 269 ? 160.915 178.222 166.191 1.00 69.90  ? 292 THR C O   1 
ATOM   4118 C CB  . THR C 3 269 ? 161.252 176.712 163.728 1.00 69.90  ? 292 THR C CB  1 
ATOM   4119 O OG1 . THR C 3 269 ? 159.946 176.398 164.227 1.00 69.90  ? 292 THR C OG1 1 
ATOM   4120 C CG2 . THR C 3 269 ? 161.651 175.682 162.682 1.00 69.90  ? 292 THR C CG2 1 
ATOM   4121 N N   . TRP C 3 270 ? 163.135 178.603 166.121 1.00 72.69  ? 293 TRP C N   1 
ATOM   4122 C CA  . TRP C 3 270 ? 163.078 179.745 167.021 1.00 72.69  ? 293 TRP C CA  1 
ATOM   4123 C C   . TRP C 3 270 ? 162.697 181.007 166.259 1.00 72.69  ? 293 TRP C C   1 
ATOM   4124 O O   . TRP C 3 270 ? 163.105 181.205 165.112 1.00 72.69  ? 293 TRP C O   1 
ATOM   4125 C CB  . TRP C 3 270 ? 164.426 179.939 167.716 1.00 72.69  ? 293 TRP C CB  1 
ATOM   4126 C CG  . TRP C 3 270 ? 164.492 181.143 168.607 1.00 72.69  ? 293 TRP C CG  1 
ATOM   4127 C CD1 . TRP C 3 270 ? 164.806 182.419 168.239 1.00 72.69  ? 293 TRP C CD1 1 
ATOM   4128 C CD2 . TRP C 3 270 ? 164.252 181.180 170.018 1.00 72.69  ? 293 TRP C CD2 1 
ATOM   4129 N NE1 . TRP C 3 270 ? 164.768 183.249 169.332 1.00 72.69  ? 293 TRP C NE1 1 
ATOM   4130 C CE2 . TRP C 3 270 ? 164.432 182.513 170.437 1.00 72.69  ? 293 TRP C CE2 1 
ATOM   4131 C CE3 . TRP C 3 270 ? 163.899 180.217 170.968 1.00 72.69  ? 293 TRP C CE3 1 
ATOM   4132 C CZ2 . TRP C 3 270 ? 164.271 182.906 171.763 1.00 72.69  ? 293 TRP C CZ2 1 
ATOM   4133 C CZ3 . TRP C 3 270 ? 163.740 180.609 172.283 1.00 72.69  ? 293 TRP C CZ3 1 
ATOM   4134 C CH2 . TRP C 3 270 ? 163.926 181.942 172.669 1.00 72.69  ? 293 TRP C CH2 1 
ATOM   4135 N N   . GLN C 3 271 ? 161.910 181.862 166.906 1.00 76.83  ? 294 GLN C N   1 
ATOM   4136 C CA  . GLN C 3 271 ? 161.494 183.140 166.345 1.00 76.83  ? 294 GLN C CA  1 
ATOM   4137 C C   . GLN C 3 271 ? 162.172 184.258 167.125 1.00 76.83  ? 294 GLN C C   1 
ATOM   4138 O O   . GLN C 3 271 ? 161.948 184.401 168.332 1.00 76.83  ? 294 GLN C O   1 
ATOM   4139 C CB  . GLN C 3 271 ? 159.973 183.293 166.393 1.00 76.83  ? 294 GLN C CB  1 
ATOM   4140 C CG  . GLN C 3 271 ? 159.220 182.324 165.496 1.00 76.83  ? 294 GLN C CG  1 
ATOM   4141 C CD  . GLN C 3 271 ? 159.405 182.623 164.021 1.00 76.83  ? 294 GLN C CD  1 
ATOM   4142 O OE1 . GLN C 3 271 ? 159.799 183.726 163.644 1.00 76.83  ? 294 GLN C OE1 1 
ATOM   4143 N NE2 . GLN C 3 271 ? 159.120 181.638 163.178 1.00 76.83  ? 294 GLN C NE2 1 
ATOM   4144 N N   . ILE C 3 272 ? 162.994 185.042 166.439 1.00 81.37  ? 295 ILE C N   1 
ATOM   4145 C CA  . ILE C 3 272 ? 163.745 186.123 167.066 1.00 81.37  ? 295 ILE C CA  1 
ATOM   4146 C C   . ILE C 3 272 ? 162.945 187.413 166.961 1.00 81.37  ? 295 ILE C C   1 
ATOM   4147 O O   . ILE C 3 272 ? 162.353 187.716 165.918 1.00 81.37  ? 295 ILE C O   1 
ATOM   4148 C CB  . ILE C 3 272 ? 165.138 186.267 166.422 1.00 81.37  ? 295 ILE C CB  1 
ATOM   4149 C CG1 . ILE C 3 272 ? 165.888 187.465 167.010 1.00 81.37  ? 295 ILE C CG1 1 
ATOM   4150 C CG2 . ILE C 3 272 ? 165.029 186.381 164.907 1.00 81.37  ? 295 ILE C CG2 1 
ATOM   4151 C CD1 . ILE C 3 272 ? 166.161 187.350 168.493 1.00 81.37  ? 295 ILE C CD1 1 
ATOM   4152 N N   . THR C 3 273 ? 162.914 188.170 168.053 1.00 86.72  ? 296 THR C N   1 
ATOM   4153 C CA  . THR C 3 273 ? 162.248 189.462 168.058 1.00 86.72  ? 296 THR C CA  1 
ATOM   4154 C C   . THR C 3 273 ? 163.165 190.533 167.483 1.00 86.72  ? 296 THR C C   1 
ATOM   4155 O O   . THR C 3 273 ? 164.394 190.415 167.516 1.00 86.72  ? 296 THR C O   1 
ATOM   4156 C CB  . THR C 3 273 ? 161.825 189.849 169.476 1.00 86.72  ? 296 THR C CB  1 
ATOM   4157 O OG1 . THR C 3 273 ? 162.954 190.375 170.185 1.00 86.72  ? 296 THR C OG1 1 
ATOM   4158 C CG2 . THR C 3 273 ? 161.285 188.639 170.218 1.00 86.72  ? 296 THR C CG2 1 
ATOM   4159 N N   . GLU C 3 274 ? 162.554 191.587 166.951 1.00 91.48  ? 297 GLU C N   1 
ATOM   4160 C CA  . GLU C 3 274 ? 163.314 192.670 166.348 1.00 91.48  ? 297 GLU C CA  1 
ATOM   4161 C C   . GLU C 3 274 ? 164.119 193.419 167.407 1.00 91.48  ? 297 GLU C C   1 
ATOM   4162 O O   . GLU C 3 274 ? 163.831 193.362 168.606 1.00 91.48  ? 297 GLU C O   1 
ATOM   4163 C CB  . GLU C 3 274 ? 162.384 193.636 165.613 1.00 91.48  ? 297 GLU C CB  1 
ATOM   4164 C CG  . GLU C 3 274 ? 161.408 192.967 164.653 1.00 91.48  ? 297 GLU C CG  1 
ATOM   4165 C CD  . GLU C 3 274 ? 162.011 191.775 163.933 1.00 91.48  ? 297 GLU C CD  1 
ATOM   4166 O OE1 . GLU C 3 274 ? 163.003 191.961 163.196 1.00 91.48  ? 297 GLU C OE1 1 
ATOM   4167 O OE2 . GLU C 3 274 ? 161.494 190.651 164.106 1.00 91.48  ? 297 GLU C OE2 1 
ATOM   4168 N N   . GLY C 3 275 ? 165.146 194.127 166.945 1.00 95.10  ? 298 GLY C N   1 
ATOM   4169 C CA  . GLY C 3 275 ? 165.999 194.889 167.835 1.00 95.10  ? 298 GLY C CA  1 
ATOM   4170 C C   . GLY C 3 275 ? 167.460 194.840 167.443 1.00 95.10  ? 298 GLY C C   1 
ATOM   4171 O O   . GLY C 3 275 ? 168.284 195.569 168.006 1.00 95.10  ? 298 GLY C O   1 
ATOM   4172 N N   . SER C 3 276 ? 167.788 193.981 166.476 1.00 96.64  ? 299 SER C N   1 
ATOM   4173 C CA  . SER C 3 276 ? 169.157 193.822 165.979 1.00 96.64  ? 299 SER C CA  1 
ATOM   4174 C C   . SER C 3 276 ? 170.125 193.477 167.109 1.00 96.64  ? 299 SER C C   1 
ATOM   4175 O O   . SER C 3 276 ? 171.250 193.978 167.165 1.00 96.64  ? 299 SER C O   1 
ATOM   4176 C CB  . SER C 3 276 ? 169.622 195.071 165.226 1.00 96.64  ? 299 SER C CB  1 
ATOM   4177 O OG  . SER C 3 276 ? 170.745 194.785 164.411 1.00 96.64  ? 299 SER C OG  1 
ATOM   4178 N N   . GLN C 3 277 ? 169.682 192.613 168.019 1.00 92.11  ? 300 GLN C N   1 
ATOM   4179 C CA  . GLN C 3 277 ? 170.527 192.154 169.114 1.00 92.11  ? 300 GLN C CA  1 
ATOM   4180 C C   . GLN C 3 277 ? 171.408 191.011 168.623 1.00 92.11  ? 300 GLN C C   1 
ATOM   4181 O O   . GLN C 3 277 ? 170.899 189.981 168.169 1.00 92.11  ? 300 GLN C O   1 
ATOM   4182 C CB  . GLN C 3 277 ? 169.670 191.709 170.297 1.00 92.11  ? 300 GLN C CB  1 
ATOM   4183 C CG  . GLN C 3 277 ? 170.449 191.042 171.418 1.00 92.11  ? 300 GLN C CG  1 
ATOM   4184 C CD  . GLN C 3 277 ? 169.663 189.934 172.091 1.00 92.11  ? 300 GLN C CD  1 
ATOM   4185 O OE1 . GLN C 3 277 ? 168.468 189.767 171.845 1.00 92.11  ? 300 GLN C OE1 1 
ATOM   4186 N NE2 . GLN C 3 277 ? 170.331 189.169 172.945 1.00 92.11  ? 300 GLN C NE2 1 
ATOM   4187 N N   . GLU C 3 278 ? 172.723 191.191 168.711 1.00 91.15  ? 301 GLU C N   1 
ATOM   4188 C CA  . GLU C 3 278 ? 173.686 190.199 168.243 1.00 91.15  ? 301 GLU C CA  1 
ATOM   4189 C C   . GLU C 3 278 ? 174.382 189.598 169.461 1.00 91.15  ? 301 GLU C C   1 
ATOM   4190 O O   . GLU C 3 278 ? 175.486 189.998 169.836 1.00 91.15  ? 301 GLU C O   1 
ATOM   4191 C CB  . GLU C 3 278 ? 174.685 190.836 167.272 1.00 91.15  ? 301 GLU C CB  1 
ATOM   4192 C CG  . GLU C 3 278 ? 174.220 190.851 165.825 1.00 91.15  ? 301 GLU C CG  1 
ATOM   4193 C CD  . GLU C 3 278 ? 175.371 190.924 164.841 1.00 91.15  ? 301 GLU C CD  1 
ATOM   4194 O OE1 . GLU C 3 278 ? 175.136 191.318 163.678 1.00 91.15  ? 301 GLU C OE1 1 
ATOM   4195 O OE2 . GLU C 3 278 ? 176.510 190.585 165.225 1.00 91.15  ? 301 GLU C OE2 1 
ATOM   4196 N N   . MET C 3 279 ? 173.723 188.618 170.074 1.00 85.61  ? 302 MET C N   1 
ATOM   4197 C CA  . MET C 3 279 ? 174.254 187.854 171.195 1.00 85.61  ? 302 MET C CA  1 
ATOM   4198 C C   . MET C 3 279 ? 173.270 186.740 171.512 1.00 85.61  ? 302 MET C C   1 
ATOM   4199 O O   . MET C 3 279 ? 172.059 186.907 171.344 1.00 85.61  ? 302 MET C O   1 
ATOM   4200 C CB  . MET C 3 279 ? 174.478 188.733 172.433 1.00 85.61  ? 302 MET C CB  1 
ATOM   4201 C CG  . MET C 3 279 ? 175.391 188.112 173.475 1.00 85.61  ? 302 MET C CG  1 
ATOM   4202 S SD  . MET C 3 279 ? 177.055 187.822 172.846 1.00 85.61  ? 302 MET C SD  1 
ATOM   4203 C CE  . MET C 3 279 ? 177.568 189.494 172.462 1.00 85.61  ? 302 MET C CE  1 
ATOM   4204 N N   . TYR C 3 280 ? 173.796 185.609 171.979 1.00 80.19  ? 303 TYR C N   1 
ATOM   4205 C CA  . TYR C 3 280 ? 172.954 184.468 172.313 1.00 80.19  ? 303 TYR C CA  1 
ATOM   4206 C C   . TYR C 3 280 ? 173.633 183.625 173.382 1.00 80.19  ? 303 TYR C C   1 
ATOM   4207 O O   . TYR C 3 280 ? 174.850 183.424 173.338 1.00 80.19  ? 303 TYR C O   1 
ATOM   4208 C CB  . TYR C 3 280 ? 172.661 183.615 171.074 1.00 80.19  ? 303 TYR C CB  1 
ATOM   4209 C CG  . TYR C 3 280 ? 171.667 184.241 170.124 1.00 80.19  ? 303 TYR C CG  1 
ATOM   4210 C CD1 . TYR C 3 280 ? 170.309 184.239 170.409 1.00 80.19  ? 303 TYR C CD1 1 
ATOM   4211 C CD2 . TYR C 3 280 ? 172.088 184.840 168.945 1.00 80.19  ? 303 TYR C CD2 1 
ATOM   4212 C CE1 . TYR C 3 280 ? 169.397 184.812 169.544 1.00 80.19  ? 303 TYR C CE1 1 
ATOM   4213 C CE2 . TYR C 3 280 ? 171.184 185.416 168.075 1.00 80.19  ? 303 TYR C CE2 1 
ATOM   4214 C CZ  . TYR C 3 280 ? 169.841 185.399 168.379 1.00 80.19  ? 303 TYR C CZ  1 
ATOM   4215 O OH  . TYR C 3 280 ? 168.938 185.972 167.513 1.00 80.19  ? 303 TYR C OH  1 
ATOM   4216 N N   . ASN C 3 281 ? 172.839 183.138 174.337 1.00 75.99  ? 304 ASN C N   1 
ATOM   4217 C CA  . ASN C 3 281 ? 173.327 182.243 175.389 1.00 75.99  ? 304 ASN C CA  1 
ATOM   4218 C C   . ASN C 3 281 ? 172.169 181.312 175.756 1.00 75.99  ? 304 ASN C C   1 
ATOM   4219 O O   . ASN C 3 281 ? 171.337 181.642 176.604 1.00 75.99  ? 304 ASN C O   1 
ATOM   4220 C CB  . ASN C 3 281 ? 173.828 183.026 176.594 1.00 75.99  ? 304 ASN C CB  1 
ATOM   4221 C CG  . ASN C 3 281 ? 174.409 182.134 177.671 1.00 75.99  ? 304 ASN C CG  1 
ATOM   4222 O OD1 . ASN C 3 281 ? 174.829 181.009 177.405 1.00 75.99  ? 304 ASN C OD1 1 
ATOM   4223 N ND2 . ASN C 3 281 ? 174.436 182.637 178.900 1.00 75.99  ? 304 ASN C ND2 1 
ATOM   4224 N N   . PHE C 3 282 ? 172.133 180.150 175.113 1.00 69.56  ? 305 PHE C N   1 
ATOM   4225 C CA  . PHE C 3 282 ? 171.031 179.211 175.260 1.00 69.56  ? 305 PHE C CA  1 
ATOM   4226 C C   . PHE C 3 282 ? 171.349 178.158 176.316 1.00 69.56  ? 305 PHE C C   1 
ATOM   4227 O O   . PHE C 3 282 ? 172.498 177.954 176.711 1.00 69.56  ? 305 PHE C O   1 
ATOM   4228 C CB  . PHE C 3 282 ? 170.715 178.540 173.920 1.00 69.56  ? 305 PHE C CB  1 
ATOM   4229 C CG  . PHE C 3 282 ? 169.975 179.425 172.957 1.00 69.56  ? 305 PHE C CG  1 
ATOM   4230 C CD1 . PHE C 3 282 ? 168.614 179.637 173.097 1.00 69.56  ? 305 PHE C CD1 1 
ATOM   4231 C CD2 . PHE C 3 282 ? 170.638 180.040 171.911 1.00 69.56  ? 305 PHE C CD2 1 
ATOM   4232 C CE1 . PHE C 3 282 ? 167.930 180.451 172.213 1.00 69.56  ? 305 PHE C CE1 1 
ATOM   4233 C CE2 . PHE C 3 282 ? 169.958 180.854 171.023 1.00 69.56  ? 305 PHE C CE2 1 
ATOM   4234 C CZ  . PHE C 3 282 ? 168.603 181.059 171.175 1.00 69.56  ? 305 PHE C CZ  1 
ATOM   4235 N N   . THR C 3 283 ? 170.295 177.482 176.775 1.00 65.08  ? 306 THR C N   1 
ATOM   4236 C CA  . THR C 3 283 ? 170.438 176.406 177.754 1.00 65.08  ? 306 THR C CA  1 
ATOM   4237 C C   . THR C 3 283 ? 169.329 175.393 177.483 1.00 65.08  ? 306 THR C C   1 
ATOM   4238 O O   . THR C 3 283 ? 168.201 175.565 177.953 1.00 65.08  ? 306 THR C O   1 
ATOM   4239 C CB  . THR C 3 283 ? 170.370 176.940 179.178 1.00 65.08  ? 306 THR C CB  1 
ATOM   4240 O OG1 . THR C 3 283 ? 171.397 177.920 179.377 1.00 65.08  ? 306 THR C OG1 1 
ATOM   4241 C CG2 . THR C 3 283 ? 170.555 175.808 180.179 1.00 65.08  ? 306 THR C CG2 1 
ATOM   4242 N N   . LEU C 3 284 ? 169.656 174.347 176.728 1.00 59.20  ? 307 LEU C N   1 
ATOM   4243 C CA  . LEU C 3 284 ? 168.694 173.297 176.423 1.00 59.20  ? 307 LEU C CA  1 
ATOM   4244 C C   . LEU C 3 284 ? 168.554 172.366 177.620 1.00 59.20  ? 307 LEU C C   1 
ATOM   4245 O O   . LEU C 3 284 ? 169.551 171.988 178.243 1.00 59.20  ? 307 LEU C O   1 
ATOM   4246 C CB  . LEU C 3 284 ? 169.133 172.516 175.186 1.00 59.20  ? 307 LEU C CB  1 
ATOM   4247 C CG  . LEU C 3 284 ? 168.245 171.344 174.765 1.00 59.20  ? 307 LEU C CG  1 
ATOM   4248 C CD1 . LEU C 3 284 ? 166.817 171.804 174.518 1.00 59.20  ? 307 LEU C CD1 1 
ATOM   4249 C CD2 . LEU C 3 284 ? 168.814 170.658 173.534 1.00 59.20  ? 307 LEU C CD2 1 
ATOM   4250 N N   . THR C 3 285 ? 167.316 172.001 177.947 1.00 59.05  ? 308 THR C N   1 
ATOM   4251 C CA  . THR C 3 285 ? 167.030 171.157 179.100 1.00 59.05  ? 308 THR C CA  1 
ATOM   4252 C C   . THR C 3 285 ? 166.062 170.055 178.703 1.00 59.05  ? 308 THR C C   1 
ATOM   4253 O O   . THR C 3 285 ? 165.007 170.330 178.122 1.00 59.05  ? 308 THR C O   1 
ATOM   4254 C CB  . THR C 3 285 ? 166.446 171.975 180.254 1.00 59.05  ? 308 THR C CB  1 
ATOM   4255 O OG1 . THR C 3 285 ? 165.547 172.962 179.734 1.00 59.05  ? 308 THR C OG1 1 
ATOM   4256 C CG2 . THR C 3 285 ? 167.552 172.655 181.042 1.00 59.05  ? 308 THR C CG2 1 
ATOM   4257 N N   . ALA C 3 286 ? 166.426 168.815 179.014 1.00 59.12  ? 309 ALA C N   1 
ATOM   4258 C CA  . ALA C 3 286 ? 165.567 167.654 178.818 1.00 59.12  ? 309 ALA C CA  1 
ATOM   4259 C C   . ALA C 3 286 ? 165.174 167.120 180.187 1.00 59.12  ? 309 ALA C C   1 
ATOM   4260 O O   . ALA C 3 286 ? 166.044 166.844 181.020 1.00 59.12  ? 309 ALA C O   1 
ATOM   4261 C CB  . ALA C 3 286 ? 166.273 166.575 177.998 1.00 59.12  ? 309 ALA C CB  1 
ATOM   4262 N N   . GLU C 3 287 ? 163.872 166.978 180.420 1.00 63.20  ? 310 GLU C N   1 
ATOM   4263 C CA  . GLU C 3 287 ? 163.371 166.588 181.728 1.00 63.20  ? 310 GLU C CA  1 
ATOM   4264 C C   . GLU C 3 287 ? 162.298 165.521 181.584 1.00 63.20  ? 310 GLU C C   1 
ATOM   4265 O O   . GLU C 3 287 ? 161.451 165.597 180.690 1.00 63.20  ? 310 GLU C O   1 
ATOM   4266 C CB  . GLU C 3 287 ? 162.801 167.794 182.487 1.00 63.20  ? 310 GLU C CB  1 
ATOM   4267 C CG  . GLU C 3 287 ? 162.379 167.485 183.915 1.00 63.20  ? 310 GLU C CG  1 
ATOM   4268 C CD  . GLU C 3 287 ? 161.679 168.652 184.580 1.00 63.20  ? 310 GLU C CD  1 
ATOM   4269 O OE1 . GLU C 3 287 ? 161.062 169.465 183.860 1.00 63.20  ? 310 GLU C OE1 1 
ATOM   4270 O OE2 . GLU C 3 287 ? 161.743 168.756 185.823 1.00 63.20  ? 310 GLU C OE2 1 
ATOM   4271 N N   . ASN C 3 288 ? 162.347 164.528 182.470 1.00 60.45  ? 311 ASN C N   1 
ATOM   4272 C CA  . ASN C 3 288 ? 161.279 163.545 182.597 1.00 60.45  ? 311 ASN C CA  1 
ATOM   4273 C C   . ASN C 3 288 ? 160.825 163.486 184.049 1.00 60.45  ? 311 ASN C C   1 
ATOM   4274 O O   . ASN C 3 288 ? 161.203 164.342 184.855 1.00 60.45  ? 311 ASN C O   1 
ATOM   4275 C CB  . ASN C 3 288 ? 161.734 162.168 182.108 1.00 60.45  ? 311 ASN C CB  1 
ATOM   4276 C CG  . ASN C 3 288 ? 163.018 161.705 182.767 1.00 60.45  ? 311 ASN C CG  1 
ATOM   4277 O OD1 . ASN C 3 288 ? 163.543 162.358 183.668 1.00 60.45  ? 311 ASN C OD1 1 
ATOM   4278 N ND2 . ASN C 3 288 ? 163.529 160.564 182.320 1.00 60.45  ? 311 ASN C ND2 1 
ATOM   4279 N N   . GLN C 3 289 ? 160.013 162.487 184.396 1.00 58.28  ? 312 GLN C N   1 
ATOM   4280 C CA  . GLN C 3 289 ? 159.518 162.374 185.762 1.00 58.28  ? 312 GLN C CA  1 
ATOM   4281 C C   . GLN C 3 289 ? 160.597 161.968 186.758 1.00 58.28  ? 312 GLN C C   1 
ATOM   4282 O O   . GLN C 3 289 ? 160.343 162.015 187.966 1.00 58.28  ? 312 GLN C O   1 
ATOM   4283 C CB  . GLN C 3 289 ? 158.365 161.370 185.823 1.00 58.28  ? 312 GLN C CB  1 
ATOM   4284 C CG  . GLN C 3 289 ? 157.143 161.777 185.020 1.00 58.28  ? 312 GLN C CG  1 
ATOM   4285 C CD  . GLN C 3 289 ? 155.982 160.820 185.206 1.00 58.28  ? 312 GLN C CD  1 
ATOM   4286 O OE1 . GLN C 3 289 ? 156.088 159.829 185.927 1.00 58.28  ? 312 GLN C OE1 1 
ATOM   4287 N NE2 . GLN C 3 289 ? 154.863 161.114 184.553 1.00 58.28  ? 312 GLN C NE2 1 
ATOM   4288 N N   . LEU C 3 290 ? 161.783 161.579 186.293 1.00 55.03  ? 313 LEU C N   1 
ATOM   4289 C CA  . LEU C 3 290 ? 162.845 161.097 187.168 1.00 55.03  ? 313 LEU C CA  1 
ATOM   4290 C C   . LEU C 3 290 ? 163.983 162.091 187.344 1.00 55.03  ? 313 LEU C C   1 
ATOM   4291 O O   . LEU C 3 290 ? 164.331 162.431 188.478 1.00 55.03  ? 313 LEU C O   1 
ATOM   4292 C CB  . LEU C 3 290 ? 163.396 159.767 186.636 1.00 55.03  ? 313 LEU C CB  1 
ATOM   4293 C CG  . LEU C 3 290 ? 162.456 158.567 186.740 1.00 55.03  ? 313 LEU C CG  1 
ATOM   4294 C CD1 . LEU C 3 290 ? 163.135 157.323 186.206 1.00 55.03  ? 313 LEU C CD1 1 
ATOM   4295 C CD2 . LEU C 3 290 ? 162.011 158.361 188.178 1.00 55.03  ? 313 LEU C CD2 1 
ATOM   4296 N N   . ARG C 3 291 ? 164.580 162.568 186.254 1.00 57.56  ? 314 ARG C N   1 
ATOM   4297 C CA  . ARG C 3 291 ? 165.757 163.424 186.342 1.00 57.56  ? 314 ARG C CA  1 
ATOM   4298 C C   . ARG C 3 291 ? 165.591 164.591 185.375 1.00 57.56  ? 314 ARG C C   1 
ATOM   4299 O O   . ARG C 3 291 ? 164.519 164.802 184.799 1.00 57.56  ? 314 ARG C O   1 
ATOM   4300 C CB  . ARG C 3 291 ? 167.035 162.621 186.064 1.00 57.56  ? 314 ARG C CB  1 
ATOM   4301 C CG  . ARG C 3 291 ? 167.025 161.877 184.742 1.00 57.56  ? 314 ARG C CG  1 
ATOM   4302 C CD  . ARG C 3 291 ? 168.398 161.314 184.410 1.00 57.56  ? 314 ARG C CD  1 
ATOM   4303 N NE  . ARG C 3 291 ? 168.909 160.435 185.458 1.00 57.56  ? 314 ARG C NE  1 
ATOM   4304 C CZ  . ARG C 3 291 ? 169.860 160.773 186.323 1.00 57.56  ? 314 ARG C CZ  1 
ATOM   4305 N NH1 . ARG C 3 291 ? 170.410 161.979 186.269 1.00 57.56  ? 314 ARG C NH1 1 
ATOM   4306 N NH2 . ARG C 3 291 ? 170.261 159.907 187.243 1.00 57.56  ? 314 ARG C NH2 1 
ATOM   4307 N N   . LYS C 3 292 ? 166.668 165.357 185.199 1.00 58.22  ? 315 LYS C N   1 
ATOM   4308 C CA  . LYS C 3 292 ? 166.630 166.552 184.360 1.00 58.22  ? 315 LYS C CA  1 
ATOM   4309 C C   . LYS C 3 292 ? 168.054 166.865 183.918 1.00 58.22  ? 315 LYS C C   1 
ATOM   4310 O O   . LYS C 3 292 ? 168.898 167.208 184.752 1.00 58.22  ? 315 LYS C O   1 
ATOM   4311 C CB  . LYS C 3 292 ? 166.013 167.720 185.121 1.00 58.22  ? 315 LYS C CB  1 
ATOM   4312 C CG  . LYS C 3 292 ? 166.224 169.077 184.480 1.00 58.22  ? 315 LYS C CG  1 
ATOM   4313 C CD  . LYS C 3 292 ? 165.755 170.189 185.401 1.00 58.22  ? 315 LYS C CD  1 
ATOM   4314 C CE  . LYS C 3 292 ? 166.140 171.553 184.856 1.00 58.22  ? 315 LYS C CE  1 
ATOM   4315 N NZ  . LYS C 3 292 ? 165.762 172.648 185.790 1.00 58.22  ? 315 LYS C NZ  1 
ATOM   4316 N N   . ARG C 3 293 ? 168.318 166.743 182.621 1.00 59.38  ? 316 ARG C N   1 
ATOM   4317 C CA  . ARG C 3 293 ? 169.628 167.025 182.053 1.00 59.38  ? 316 ARG C CA  1 
ATOM   4318 C C   . ARG C 3 293 ? 169.646 168.412 181.421 1.00 59.38  ? 316 ARG C C   1 
ATOM   4319 O O   . ARG C 3 293 ? 168.611 168.935 181.000 1.00 59.38  ? 316 ARG C O   1 
ATOM   4320 C CB  . ARG C 3 293 ? 170.005 165.975 181.007 1.00 59.38  ? 316 ARG C CB  1 
ATOM   4321 C CG  . ARG C 3 293 ? 170.303 164.603 181.582 1.00 59.38  ? 316 ARG C CG  1 
ATOM   4322 C CD  . ARG C 3 293 ? 171.518 164.637 182.493 1.00 59.38  ? 316 ARG C CD  1 
ATOM   4323 N NE  . ARG C 3 293 ? 171.787 163.335 183.095 1.00 59.38  ? 316 ARG C NE  1 
ATOM   4324 C CZ  . ARG C 3 293 ? 172.513 162.381 182.521 1.00 59.38  ? 316 ARG C CZ  1 
ATOM   4325 N NH1 . ARG C 3 293 ? 173.045 162.579 181.323 1.00 59.38  ? 316 ARG C NH1 1 
ATOM   4326 N NH2 . ARG C 3 293 ? 172.707 161.228 183.144 1.00 59.38  ? 316 ARG C NH2 1 
ATOM   4327 N N   . SER C 3 294 ? 170.838 169.005 181.352 1.00 57.94  ? 317 SER C N   1 
ATOM   4328 C CA  . SER C 3 294 ? 170.982 170.356 180.829 1.00 57.94  ? 317 SER C CA  1 
ATOM   4329 C C   . SER C 3 294 ? 172.308 170.488 180.094 1.00 57.94  ? 317 SER C C   1 
ATOM   4330 O O   . SER C 3 294 ? 173.315 169.901 180.501 1.00 57.94  ? 317 SER C O   1 
ATOM   4331 C CB  . SER C 3 294 ? 170.894 171.399 181.950 1.00 57.94  ? 317 SER C CB  1 
ATOM   4332 O OG  . SER C 3 294 ? 171.490 172.622 181.559 1.00 57.94  ? 317 SER C OG  1 
ATOM   4333 N N   . VAL C 3 295 ? 172.295 171.259 179.009 1.00 60.54  ? 318 VAL C N   1 
ATOM   4334 C CA  . VAL C 3 295 ? 173.484 171.542 178.213 1.00 60.54  ? 318 VAL C CA  1 
ATOM   4335 C C   . VAL C 3 295 ? 173.401 172.984 177.728 1.00 60.54  ? 318 VAL C C   1 
ATOM   4336 O O   . VAL C 3 295 ? 172.337 173.448 177.304 1.00 60.54  ? 318 VAL C O   1 
ATOM   4337 C CB  . VAL C 3 295 ? 173.623 170.556 177.033 1.00 60.54  ? 318 VAL C CB  1 
ATOM   4338 C CG1 . VAL C 3 295 ? 172.325 170.474 176.243 1.00 60.54  ? 318 VAL C CG1 1 
ATOM   4339 C CG2 . VAL C 3 295 ? 174.780 170.953 176.130 1.00 60.54  ? 318 VAL C CG2 1 
ATOM   4340 N N   . ASN C 3 296 ? 174.521 173.698 177.803 1.00 66.65  ? 319 ASN C N   1 
ATOM   4341 C CA  . ASN C 3 296 ? 174.575 175.108 177.445 1.00 66.65  ? 319 ASN C CA  1 
ATOM   4342 C C   . ASN C 3 296 ? 175.433 175.306 176.205 1.00 66.65  ? 319 ASN C C   1 
ATOM   4343 O O   . ASN C 3 296 ? 176.511 174.715 176.081 1.00 66.65  ? 319 ASN C O   1 
ATOM   4344 C CB  . ASN C 3 296 ? 175.125 175.946 178.602 1.00 66.65  ? 319 ASN C CB  1 
ATOM   4345 C CG  . ASN C 3 296 ? 175.655 177.287 178.146 1.00 66.65  ? 319 ASN C CG  1 
ATOM   4346 O OD1 . ASN C 3 296 ? 176.855 177.452 177.935 1.00 66.65  ? 319 ASN C OD1 1 
ATOM   4347 N ND2 . ASN C 3 296 ? 174.760 178.254 177.989 1.00 66.65  ? 319 ASN C ND2 1 
ATOM   4348 N N   . ILE C 3 297 ? 174.947 176.143 175.287 1.00 68.29  ? 320 ILE C N   1 
ATOM   4349 C CA  . ILE C 3 297 ? 175.667 176.490 174.071 1.00 68.29  ? 320 ILE C CA  1 
ATOM   4350 C C   . ILE C 3 297 ? 175.795 178.005 173.997 1.00 68.29  ? 320 ILE C C   1 
ATOM   4351 O O   . ILE C 3 297 ? 175.014 178.751 174.591 1.00 68.29  ? 320 ILE C O   1 
ATOM   4352 C CB  . ILE C 3 297 ? 174.980 175.947 172.799 1.00 68.29  ? 320 ILE C CB  1 
ATOM   4353 C CG1 . ILE C 3 297 ? 173.585 176.551 172.640 1.00 68.29  ? 320 ILE C CG1 1 
ATOM   4354 C CG2 . ILE C 3 297 ? 174.906 174.430 172.838 1.00 68.29  ? 320 ILE C CG2 1 
ATOM   4355 C CD1 . ILE C 3 297 ? 172.863 176.092 171.390 1.00 68.29  ? 320 ILE C CD1 1 
ATOM   4356 N N   . ASN C 3 298 ? 176.801 178.454 173.252 1.00 71.10  ? 321 ASN C N   1 
ATOM   4357 C CA  . ASN C 3 298 ? 177.083 179.876 173.113 1.00 71.10  ? 321 ASN C CA  1 
ATOM   4358 C C   . ASN C 3 298 ? 177.613 180.132 171.712 1.00 71.10  ? 321 ASN C C   1 
ATOM   4359 O O   . ASN C 3 298 ? 178.585 179.497 171.293 1.00 71.10  ? 321 ASN C O   1 
ATOM   4360 C CB  . ASN C 3 298 ? 178.095 180.342 174.164 1.00 71.10  ? 321 ASN C CB  1 
ATOM   4361 C CG  . ASN C 3 298 ? 178.429 181.812 174.040 1.00 71.10  ? 321 ASN C CG  1 
ATOM   4362 O OD1 . ASN C 3 298 ? 177.626 182.603 173.548 1.00 71.10  ? 321 ASN C OD1 1 
ATOM   4363 N ND2 . ASN C 3 298 ? 179.622 182.187 174.486 1.00 71.10  ? 321 ASN C ND2 1 
ATOM   4364 N N   . PHE C 3 299 ? 176.978 181.056 170.996 1.00 75.41  ? 322 PHE C N   1 
ATOM   4365 C CA  . PHE C 3 299 ? 177.355 181.341 169.619 1.00 75.41  ? 322 PHE C CA  1 
ATOM   4366 C C   . PHE C 3 299 ? 177.016 182.790 169.294 1.00 75.41  ? 322 PHE C C   1 
ATOM   4367 O O   . PHE C 3 299 ? 176.527 183.544 170.141 1.00 75.41  ? 322 PHE C O   1 
ATOM   4368 C CB  . PHE C 3 299 ? 176.666 180.374 168.653 1.00 75.41  ? 322 PHE C CB  1 
ATOM   4369 C CG  . PHE C 3 299 ? 175.184 180.585 168.529 1.00 75.41  ? 322 PHE C CG  1 
ATOM   4370 C CD1 . PHE C 3 299 ? 174.312 180.013 169.439 1.00 75.41  ? 322 PHE C CD1 1 
ATOM   4371 C CD2 . PHE C 3 299 ? 174.661 181.344 167.496 1.00 75.41  ? 322 PHE C CD2 1 
ATOM   4372 C CE1 . PHE C 3 299 ? 172.950 180.201 169.325 1.00 75.41  ? 322 PHE C CE1 1 
ATOM   4373 C CE2 . PHE C 3 299 ? 173.299 181.536 167.377 1.00 75.41  ? 322 PHE C CE2 1 
ATOM   4374 C CZ  . PHE C 3 299 ? 172.443 180.963 168.293 1.00 75.41  ? 322 PHE C CZ  1 
ATOM   4375 N N   . ASN C 3 300 ? 177.283 183.173 168.049 1.00 83.21  ? 323 ASN C N   1 
ATOM   4376 C CA  . ASN C 3 300 ? 177.031 184.514 167.548 1.00 83.21  ? 323 ASN C CA  1 
ATOM   4377 C C   . ASN C 3 300 ? 176.085 184.447 166.358 1.00 83.21  ? 323 ASN C C   1 
ATOM   4378 O O   . ASN C 3 300 ? 176.010 183.431 165.661 1.00 83.21  ? 323 ASN C O   1 
ATOM   4379 C CB  . ASN C 3 300 ? 178.335 185.202 167.136 1.00 83.21  ? 323 ASN C CB  1 
ATOM   4380 C CG  . ASN C 3 300 ? 178.455 186.604 167.688 1.00 83.21  ? 323 ASN C CG  1 
ATOM   4381 O OD1 . ASN C 3 300 ? 177.464 187.325 167.812 1.00 83.21  ? 323 ASN C OD1 1 
ATOM   4382 N ND2 . ASN C 3 300 ? 179.676 187.000 168.025 1.00 83.21  ? 323 ASN C ND2 1 
ATOM   4383 N N   . LEU C 3 301 ? 175.366 185.546 166.121 1.00 81.01  ? 324 LEU C N   1 
ATOM   4384 C CA  . LEU C 3 301 ? 174.375 185.553 165.050 1.00 81.01  ? 324 LEU C CA  1 
ATOM   4385 C C   . LEU C 3 301 ? 175.023 185.687 163.676 1.00 81.01  ? 324 LEU C C   1 
ATOM   4386 O O   . LEU C 3 301 ? 174.645 184.975 162.739 1.00 81.01  ? 324 LEU C O   1 
ATOM   4387 C CB  . LEU C 3 301 ? 173.365 186.677 165.276 1.00 81.01  ? 324 LEU C CB  1 
ATOM   4388 C CG  . LEU C 3 301 ? 172.155 186.678 164.340 1.00 81.01  ? 324 LEU C CG  1 
ATOM   4389 C CD1 . LEU C 3 301 ? 171.484 185.313 164.330 1.00 81.01  ? 324 LEU C CD1 1 
ATOM   4390 C CD2 . LEU C 3 301 ? 171.166 187.759 164.743 1.00 81.01  ? 324 LEU C CD2 1 
ATOM   4391 N N   . THR C 3 302 ? 175.995 186.589 163.534 1.00 82.83  ? 325 THR C N   1 
ATOM   4392 C CA  . THR C 3 302 ? 176.652 186.787 162.249 1.00 82.83  ? 325 THR C CA  1 
ATOM   4393 C C   . THR C 3 302 ? 177.662 185.694 161.926 1.00 82.83  ? 325 THR C C   1 
ATOM   4394 O O   . THR C 3 302 ? 177.909 185.428 160.744 1.00 82.83  ? 325 THR C O   1 
ATOM   4395 C CB  . THR C 3 302 ? 177.348 188.152 162.220 1.00 82.83  ? 325 THR C CB  1 
ATOM   4396 O OG1 . THR C 3 302 ? 176.450 189.155 162.705 1.00 82.83  ? 325 THR C OG1 1 
ATOM   4397 C CG2 . THR C 3 302 ? 177.770 188.517 160.801 1.00 82.83  ? 325 THR C CG2 1 
ATOM   4398 N N   . HIS C 3 303 ? 178.226 185.036 162.935 1.00 81.32  ? 326 HIS C N   1 
ATOM   4399 C CA  . HIS C 3 303 ? 179.214 183.989 162.721 1.00 81.32  ? 326 HIS C CA  1 
ATOM   4400 C C   . HIS C 3 303 ? 178.580 182.655 162.358 1.00 81.32  ? 326 HIS C C   1 
ATOM   4401 O O   . HIS C 3 303 ? 179.305 181.681 162.134 1.00 81.32  ? 326 HIS C O   1 
ATOM   4402 C CB  . HIS C 3 303 ? 180.090 183.825 163.968 1.00 81.32  ? 326 HIS C CB  1 
ATOM   4403 C CG  . HIS C 3 303 ? 180.915 185.033 164.293 1.00 81.32  ? 326 HIS C CG  1 
ATOM   4404 N ND1 . HIS C 3 303 ? 181.903 185.022 165.253 1.00 81.32  ? 326 HIS C ND1 1 
ATOM   4405 C CD2 . HIS C 3 303 ? 180.897 186.288 163.786 1.00 81.32  ? 326 HIS C CD2 1 
ATOM   4406 C CE1 . HIS C 3 303 ? 182.459 186.218 165.324 1.00 81.32  ? 326 HIS C CE1 1 
ATOM   4407 N NE2 . HIS C 3 303 ? 181.867 187.005 164.444 1.00 81.32  ? 326 HIS C NE2 1 
ATOM   4408 N N   . ARG C 3 304 ? 177.255 182.589 162.294 1.00 78.32  ? 327 ARG C N   1 
ATOM   4409 C CA  . ARG C 3 304 ? 176.559 181.369 161.910 1.00 78.32  ? 327 ARG C CA  1 
ATOM   4410 C C   . ARG C 3 304 ? 175.422 181.678 160.944 1.00 78.32  ? 327 ARG C C   1 
ATOM   4411 O O   . ARG C 3 304 ? 174.636 180.799 160.593 1.00 78.32  ? 327 ARG C O   1 
ATOM   4412 C CB  . ARG C 3 304 ? 176.019 180.646 163.144 1.00 78.32  ? 327 ARG C CB  1 
ATOM   4413 C CG  . ARG C 3 304 ? 177.086 179.942 163.962 1.00 78.32  ? 327 ARG C CG  1 
ATOM   4414 C CD  . ARG C 3 304 ? 176.489 179.300 165.198 1.00 78.32  ? 327 ARG C CD  1 
ATOM   4415 N NE  . ARG C 3 304 ? 177.492 178.588 165.983 1.00 78.32  ? 327 ARG C NE  1 
ATOM   4416 C CZ  . ARG C 3 304 ? 177.647 177.269 165.974 1.00 78.32  ? 327 ARG C CZ  1 
ATOM   4417 N NH1 . ARG C 3 304 ? 176.863 176.513 165.219 1.00 78.32  ? 327 ARG C NH1 1 
ATOM   4418 N NH2 . ARG C 3 304 ? 178.585 176.705 166.721 1.00 78.32  ? 327 ARG C NH2 1 
HETATM 4419 C C1  . NAG D 4 .   ? 136.606 151.594 129.876 1.00 84.73  ? 1   NAG D C1  1 
HETATM 4420 C C2  . NAG D 4 .   ? 136.939 150.455 128.911 1.00 84.73  ? 1   NAG D C2  1 
HETATM 4421 C C3  . NAG D 4 .   ? 138.435 150.439 128.582 1.00 84.73  ? 1   NAG D C3  1 
HETATM 4422 C C4  . NAG D 4 .   ? 139.290 150.547 129.841 1.00 84.73  ? 1   NAG D C4  1 
HETATM 4423 C C5  . NAG D 4 .   ? 138.802 151.680 130.738 1.00 84.73  ? 1   NAG D C5  1 
HETATM 4424 C C6  . NAG D 4 .   ? 139.882 152.686 131.063 0.00 84.73  ? 1   NAG D C6  1 
HETATM 4425 C C7  . NAG D 4 .   ? 135.493 148.473 128.964 0.00 84.73  ? 1   NAG D C7  1 
HETATM 4426 C C8  . NAG D 4 .   ? 135.202 147.169 129.643 0.00 84.73  ? 1   NAG D C8  1 
HETATM 4427 N N2  . NAG D 4 .   ? 136.522 149.172 129.453 1.00 84.73  ? 1   NAG D N2  1 
HETATM 4428 O O3  . NAG D 4 .   ? 138.736 151.514 127.699 1.00 84.73  ? 1   NAG D O3  1 
HETATM 4429 O O4  . NAG D 4 .   ? 139.239 149.322 130.565 0.50 84.73  ? 1   NAG D O4  1 
HETATM 4430 O O5  . NAG D 4 .   ? 137.754 152.398 130.077 1.00 84.73  ? 1   NAG D O5  1 
HETATM 4431 O O6  . NAG D 4 .   ? 140.337 152.545 132.402 0.00 84.73  ? 1   NAG D O6  1 
HETATM 4432 O O7  . NAG D 4 .   ? 134.827 148.875 128.015 0.00 84.73  ? 1   NAG D O7  1 
HETATM 4433 C C1  . NAG D 4 .   ? 140.575 148.803 130.752 0.50 91.77  ? 2   NAG D C1  1 
HETATM 4434 C C2  . NAG D 4 .   ? 140.991 148.047 129.486 0.50 91.77  ? 2   NAG D C2  1 
HETATM 4435 C C3  . NAG D 4 .   ? 142.419 147.521 129.622 0.50 91.77  ? 2   NAG D C3  1 
HETATM 4436 C C4  . NAG D 4 .   ? 143.367 148.651 130.002 1.00 91.77  ? 2   NAG D C4  1 
HETATM 4437 C C5  . NAG D 4 .   ? 142.858 149.376 131.246 1.00 91.77  ? 2   NAG D C5  1 
HETATM 4438 C C6  . NAG D 4 .   ? 143.694 150.580 131.613 1.00 91.77  ? 2   NAG D C6  1 
HETATM 4439 C C7  . NAG D 4 .   ? 139.823 145.920 129.976 1.00 91.77  ? 2   NAG D C7  1 
HETATM 4440 C C8  . NAG D 4 .   ? 138.832 144.920 129.461 1.00 91.77  ? 2   NAG D C8  1 
HETATM 4441 N N2  . NAG D 4 .   ? 140.066 146.966 129.174 1.00 91.77  ? 2   NAG D N2  1 
HETATM 4442 O O3  . NAG D 4 .   ? 142.828 146.935 128.392 1.00 91.77  ? 2   NAG D O3  1 
HETATM 4443 O O4  . NAG D 4 .   ? 144.665 148.129 130.262 0.50 91.77  ? 2   NAG D O4  1 
HETATM 4444 O O5  . NAG D 4 .   ? 141.522 149.851 131.022 0.50 91.77  ? 2   NAG D O5  1 
HETATM 4445 O O6  . NAG D 4 .   ? 143.129 151.780 131.103 1.00 91.77  ? 2   NAG D O6  1 
HETATM 4446 O O7  . NAG D 4 .   ? 140.374 145.785 131.066 1.00 91.77  ? 2   NAG D O7  1 
HETATM 4447 C C1  . NAG E 4 .   ? 171.839 147.829 195.871 1.00 78.34  ? 1   NAG E C1  1 
HETATM 4448 C C2  . NAG E 4 .   ? 172.833 148.994 196.014 1.00 78.34  ? 1   NAG E C2  1 
HETATM 4449 C C3  . NAG E 4 .   ? 173.642 148.878 197.311 1.00 78.34  ? 1   NAG E C3  1 
HETATM 4450 C C4  . NAG E 4 .   ? 174.362 147.537 197.414 1.00 78.34  ? 1   NAG E C4  1 
HETATM 4451 C C5  . NAG E 4 .   ? 173.538 146.431 196.770 1.00 78.34  ? 1   NAG E C5  1 
HETATM 4452 C C6  . NAG E 4 .   ? 173.649 145.112 197.498 0.10 78.34  ? 1   NAG E C6  1 
HETATM 4453 C C7  . NAG E 4 .   ? 173.505 149.908 193.838 0.10 78.34  ? 1   NAG E C7  1 
HETATM 4454 C C8  . NAG E 4 .   ? 174.517 149.860 192.733 0.10 78.34  ? 1   NAG E C8  1 
HETATM 4455 N N2  . NAG E 4 .   ? 173.717 149.075 194.862 0.10 78.34  ? 1   NAG E N2  1 
HETATM 4456 O O3  . NAG E 4 .   ? 172.774 149.049 198.426 1.00 78.34  ? 1   NAG E O3  1 
HETATM 4457 O O4  . NAG E 4 .   ? 175.635 147.610 196.782 1.00 78.34  ? 1   NAG E O4  1 
HETATM 4458 O O5  . NAG E 4 .   ? 172.157 146.807 196.805 1.00 78.34  ? 1   NAG E O5  1 
HETATM 4459 O O6  . NAG E 4 .   ? 173.091 145.189 198.802 0.10 78.34  ? 1   NAG E O6  1 
HETATM 4460 O O7  . NAG E 4 .   ? 172.541 150.666 193.805 0.10 78.34  ? 1   NAG E O7  1 
HETATM 4461 C C1  . NAG E 4 .   ? 176.546 148.304 197.656 1.00 90.21  ? 2   NAG E C1  1 
HETATM 4462 C C2  . NAG E 4 .   ? 177.640 147.334 198.116 1.00 90.21  ? 2   NAG E C2  1 
HETATM 4463 C C3  . NAG E 4 .   ? 178.670 148.059 198.982 1.00 90.21  ? 2   NAG E C3  1 
HETATM 4464 C C4  . NAG E 4 .   ? 179.202 149.290 198.260 1.00 90.21  ? 2   NAG E C4  1 
HETATM 4465 C C5  . NAG E 4 .   ? 178.046 150.177 197.807 1.00 90.21  ? 2   NAG E C5  1 
HETATM 4466 C C6  . NAG E 4 .   ? 178.498 151.361 196.984 1.00 90.21  ? 2   NAG E C6  1 
HETATM 4467 C C7  . NAG E 4 .   ? 176.392 146.265 199.968 1.00 90.21  ? 2   NAG E C7  1 
HETATM 4468 C C8  . NAG E 4 .   ? 175.909 144.961 200.528 1.00 90.21  ? 2   NAG E C8  1 
HETATM 4469 N N2  . NAG E 4 .   ? 177.083 146.188 198.822 1.00 90.21  ? 2   NAG E N2  1 
HETATM 4470 O O3  . NAG E 4 .   ? 179.740 147.173 199.287 1.00 90.21  ? 2   NAG E O3  1 
HETATM 4471 O O4  . NAG E 4 .   ? 180.051 150.033 199.126 1.00 90.21  ? 2   NAG E O4  1 
HETATM 4472 O O5  . NAG E 4 .   ? 177.144 149.422 196.986 1.00 90.21  ? 2   NAG E O5  1 
HETATM 4473 O O6  . NAG E 4 .   ? 179.186 150.945 195.812 1.00 90.21  ? 2   NAG E O6  1 
HETATM 4474 O O7  . NAG E 4 .   ? 176.163 147.335 200.528 1.00 90.21  ? 2   NAG E O7  1 
HETATM 4475 C C1  . NAG F 4 .   ? 155.904 168.300 179.807 1.00 67.29  ? 1   NAG F C1  1 
HETATM 4476 C C2  . NAG F 4 .   ? 155.470 168.906 181.149 1.00 67.29  ? 1   NAG F C2  1 
HETATM 4477 C C3  . NAG F 4 .   ? 154.343 169.930 180.957 1.00 67.29  ? 1   NAG F C3  1 
HETATM 4478 C C4  . NAG F 4 .   ? 153.187 169.362 180.140 1.00 67.29  ? 1   NAG F C4  1 
HETATM 4479 C C5  . NAG F 4 .   ? 153.700 168.498 178.996 1.00 67.29  ? 1   NAG F C5  1 
HETATM 4480 C C6  . NAG F 4 .   ? 152.983 168.757 177.691 0.10 67.29  ? 1   NAG F C6  1 
HETATM 4481 C C7  . NAG F 4 .   ? 155.940 167.187 182.834 0.10 67.29  ? 1   NAG F C7  1 
HETATM 4482 C C8  . NAG F 4 .   ? 155.354 166.153 183.748 0.10 67.29  ? 1   NAG F C8  1 
HETATM 4483 N N2  . NAG F 4 .   ? 155.068 167.870 182.086 0.10 67.29  ? 1   NAG F N2  1 
HETATM 4484 O O3  . NAG F 4 .   ? 154.864 171.090 180.318 1.00 67.29  ? 1   NAG F O3  1 
HETATM 4485 O O4  . NAG F 4 .   ? 152.327 168.590 180.971 1.00 67.29  ? 1   NAG F O4  1 
HETATM 4486 O O5  . NAG F 4 .   ? 155.082 168.794 178.773 1.00 67.29  ? 1   NAG F O5  1 
HETATM 4487 O O6  . NAG F 4 .   ? 153.032 170.131 177.334 0.10 67.29  ? 1   NAG F O6  1 
HETATM 4488 O O7  . NAG F 4 .   ? 157.148 167.394 182.776 0.10 67.29  ? 1   NAG F O7  1 
HETATM 4489 C C1  . NAG F 4 .   ? 151.442 169.489 181.669 1.00 77.61  ? 2   NAG F C1  1 
HETATM 4490 C C2  . NAG F 4 .   ? 149.997 169.202 181.246 1.00 77.61  ? 2   NAG F C2  1 
HETATM 4491 C C3  . NAG F 4 .   ? 149.028 170.092 182.022 1.00 77.61  ? 2   NAG F C3  1 
HETATM 4492 C C4  . NAG F 4 .   ? 149.266 169.958 183.520 1.00 77.61  ? 2   NAG F C4  1 
HETATM 4493 C C5  . NAG F 4 .   ? 150.733 170.218 183.848 1.00 77.61  ? 2   NAG F C5  1 
HETATM 4494 C C6  . NAG F 4 .   ? 151.063 169.986 185.304 1.00 77.61  ? 2   NAG F C6  1 
HETATM 4495 C C7  . NAG F 4 .   ? 149.989 170.513 179.146 1.00 77.61  ? 2   NAG F C7  1 
HETATM 4496 C C8  . NAG F 4 .   ? 149.740 170.459 177.669 1.00 77.61  ? 2   NAG F C8  1 
HETATM 4497 N N2  . NAG F 4 .   ? 149.811 169.362 179.810 1.00 77.61  ? 2   NAG F N2  1 
HETATM 4498 O O3  . NAG F 4 .   ? 147.690 169.724 181.705 1.00 77.61  ? 2   NAG F O3  1 
HETATM 4499 O O4  . NAG F 4 .   ? 148.456 170.892 184.225 1.00 77.61  ? 2   NAG F O4  1 
HETATM 4500 O O5  . NAG F 4 .   ? 151.568 169.331 183.089 1.00 77.61  ? 2   NAG F O5  1 
HETATM 4501 O O6  . NAG F 4 .   ? 151.008 168.605 185.635 1.00 77.61  ? 2   NAG F O6  1 
HETATM 4502 O O7  . NAG F 4 .   ? 150.336 171.549 179.707 1.00 77.61  ? 2   NAG F O7  1 
HETATM 4503 C C1  . NAG G 4 .   ? 174.967 181.888 180.011 1.00 85.63  ? 1   NAG G C1  1 
HETATM 4504 C C2  . NAG G 4 .   ? 175.058 182.758 181.271 1.00 85.63  ? 1   NAG G C2  1 
HETATM 4505 C C3  . NAG G 4 .   ? 174.237 182.156 182.415 1.00 85.63  ? 1   NAG G C3  1 
HETATM 4506 C C4  . NAG G 4 .   ? 174.599 180.696 182.660 1.00 85.63  ? 1   NAG G C4  1 
HETATM 4507 C C5  . NAG G 4 .   ? 174.750 179.946 181.342 1.00 85.63  ? 1   NAG G C5  1 
HETATM 4508 C C6  . NAG G 4 .   ? 174.027 178.620 181.328 0.10 85.63  ? 1   NAG G C6  1 
HETATM 4509 C C7  . NAG G 4 .   ? 177.101 184.097 181.522 0.10 85.63  ? 1   NAG G C7  1 
HETATM 4510 C C8  . NAG G 4 .   ? 178.522 184.110 181.996 0.10 85.63  ? 1   NAG G C8  1 
HETATM 4511 N N2  . NAG G 4 .   ? 176.442 182.943 181.677 0.10 85.63  ? 1   NAG G N2  1 
HETATM 4512 O O3  . NAG G 4 .   ? 172.851 182.267 182.110 1.00 85.63  ? 1   NAG G O3  1 
HETATM 4513 O O4  . NAG G 4 .   ? 175.817 180.613 183.391 1.00 85.63  ? 1   NAG G O4  1 
HETATM 4514 O O5  . NAG G 4 .   ? 174.192 180.734 180.284 1.00 85.63  ? 1   NAG G O5  1 
HETATM 4515 O O6  . NAG G 4 .   ? 172.621 178.795 181.215 0.10 85.63  ? 1   NAG G O6  1 
HETATM 4516 O O7  . NAG G 4 .   ? 176.572 185.084 181.021 0.10 85.63  ? 1   NAG G O7  1 
HETATM 4517 C C1  . NAG G 4 .   ? 175.524 180.810 184.789 1.00 95.45  ? 2   NAG G C1  1 
HETATM 4518 C C2  . NAG G 4 .   ? 176.055 179.607 185.574 1.00 95.45  ? 2   NAG G C2  1 
HETATM 4519 C C3  . NAG G 4 .   ? 175.821 179.800 187.071 1.00 95.45  ? 2   NAG G C3  1 
HETATM 4520 C C4  . NAG G 4 .   ? 176.393 181.135 187.531 1.00 95.45  ? 2   NAG G C4  1 
HETATM 4521 C C5  . NAG G 4 .   ? 175.846 182.270 186.670 1.00 95.45  ? 2   NAG G C5  1 
HETATM 4522 C C6  . NAG G 4 .   ? 176.460 183.611 186.999 1.00 95.45  ? 2   NAG G C6  1 
HETATM 4523 C C7  . NAG G 4 .   ? 174.152 178.080 185.155 1.00 95.45  ? 2   NAG G C7  1 
HETATM 4524 C C8  . NAG G 4 .   ? 173.754 176.735 184.626 1.00 95.45  ? 2   NAG G C8  1 
HETATM 4525 N N2  . NAG G 4 .   ? 175.462 178.360 185.111 1.00 95.45  ? 2   NAG G N2  1 
HETATM 4526 O O3  . NAG G 4 .   ? 176.432 178.735 187.788 1.00 95.45  ? 2   NAG G O3  1 
HETATM 4527 O O4  . NAG G 4 .   ? 176.045 181.369 188.891 1.00 95.45  ? 2   NAG G O4  1 
HETATM 4528 O O5  . NAG G 4 .   ? 176.127 182.014 185.286 1.00 95.45  ? 2   NAG G O5  1 
HETATM 4529 O O6  . NAG G 4 .   ? 177.821 183.477 187.387 1.00 95.45  ? 2   NAG G O6  1 
HETATM 4530 O O7  . NAG G 4 .   ? 173.325 178.872 185.599 1.00 95.45  ? 2   NAG G O7  1 
HETATM 4531 C C1  . NAG H 4 .   ? 179.927 188.312 168.558 1.00 98.84  ? 1   NAG H C1  1 
HETATM 4532 C C2  . NAG H 4 .   ? 181.417 188.502 168.845 1.00 98.84  ? 1   NAG H C2  1 
HETATM 4533 C C3  . NAG H 4 .   ? 181.903 189.860 168.328 1.00 98.84  ? 1   NAG H C3  1 
HETATM 4534 C C4  . NAG H 4 .   ? 180.921 190.980 168.659 1.00 98.84  ? 1   NAG H C4  1 
HETATM 4535 C C5  . NAG H 4 .   ? 179.496 190.607 168.259 1.00 98.84  ? 1   NAG H C5  1 
HETATM 4536 C C6  . NAG H 4 .   ? 178.899 191.556 167.246 0.10 98.84  ? 1   NAG H C6  1 
HETATM 4537 C C7  . NAG H 4 .   ? 182.854 187.883 170.734 0.10 98.84  ? 1   NAG H C7  1 
HETATM 4538 C C8  . NAG H 4 .   ? 182.977 187.810 172.226 0.10 98.84  ? 1   NAG H C8  1 
HETATM 4539 N N2  . NAG H 4 .   ? 181.699 188.364 170.264 0.10 98.84  ? 1   NAG H N2  1 
HETATM 4540 O O3  . NAG H 4 .   ? 182.098 189.786 166.920 1.00 98.84  ? 1   NAG H O3  1 
HETATM 4541 O O4  . NAG H 4 .   ? 180.953 191.265 170.052 1.00 98.84  ? 1   NAG H O4  1 
HETATM 4542 O O5  . NAG H 4 .   ? 179.487 189.306 167.663 1.00 98.84  ? 1   NAG H O5  1 
HETATM 4543 O O6  . NAG H 4 .   ? 178.797 190.951 165.964 0.10 98.84  ? 1   NAG H O6  1 
HETATM 4544 O O7  . NAG H 4 .   ? 183.760 187.523 169.989 0.10 98.84  ? 1   NAG H O7  1 
HETATM 4545 C C1  . NAG H 4 .   ? 182.046 192.160 170.327 1.00 109.85 ? 2   NAG H C1  1 
HETATM 4546 C C2  . NAG H 4 .   ? 181.485 193.520 170.757 1.00 109.85 ? 2   NAG H C2  1 
HETATM 4547 C C3  . NAG H 4 .   ? 182.617 194.471 171.146 1.00 109.85 ? 2   NAG H C3  1 
HETATM 4548 C C4  . NAG H 4 .   ? 183.529 193.823 172.179 1.00 109.85 ? 2   NAG H C4  1 
HETATM 4549 C C5  . NAG H 4 .   ? 184.012 192.466 171.675 1.00 109.85 ? 2   NAG H C5  1 
HETATM 4550 C C6  . NAG H 4 .   ? 184.839 191.716 172.693 1.00 109.85 ? 2   NAG H C6  1 
HETATM 4551 C C7  . NAG H 4 .   ? 181.077 194.451 168.500 1.00 109.85 ? 2   NAG H C7  1 
HETATM 4552 C C8  . NAG H 4 .   ? 180.047 195.046 167.588 1.00 109.85 ? 2   NAG H C8  1 
HETATM 4553 N N2  . NAG H 4 .   ? 180.646 194.110 169.723 1.00 109.85 ? 2   NAG H N2  1 
HETATM 4554 O O3  . NAG H 4 .   ? 182.068 195.674 171.670 1.00 109.85 ? 2   NAG H O3  1 
HETATM 4555 O O4  . NAG H 4 .   ? 184.652 194.660 172.427 1.00 109.85 ? 2   NAG H O4  1 
HETATM 4556 O O5  . NAG H 4 .   ? 182.885 191.635 171.362 1.00 109.85 ? 2   NAG H O5  1 
HETATM 4557 O O6  . NAG H 4 .   ? 184.370 191.946 174.015 1.00 109.85 ? 2   NAG H O6  1 
HETATM 4558 O O7  . NAG H 4 .   ? 182.241 194.287 168.143 1.00 109.85 ? 2   NAG H O7  1 
HETATM 4559 C C1  . NAG I 5 .   ? 162.780 131.839 149.785 1.00 86.98  ? 701 NAG B C1  1 
HETATM 4560 C C2  . NAG I 5 .   ? 162.692 131.455 151.261 1.00 86.98  ? 701 NAG B C2  1 
HETATM 4561 C C3  . NAG I 5 .   ? 164.069 131.533 151.926 1.00 86.98  ? 701 NAG B C3  1 
HETATM 4562 C C4  . NAG I 5 .   ? 164.828 132.789 151.506 1.00 86.98  ? 701 NAG B C4  1 
HETATM 4563 C C5  . NAG I 5 .   ? 164.859 132.937 149.988 1.00 86.98  ? 701 NAG B C5  1 
HETATM 4564 C C6  . NAG I 5 .   ? 166.257 132.896 149.417 1.00 86.98  ? 701 NAG B C6  1 
HETATM 4565 C C7  . NAG I 5 .   ? 160.535 131.870 152.356 1.00 86.98  ? 701 NAG B C7  1 
HETATM 4566 C C8  . NAG I 5 .   ? 159.679 132.875 153.065 1.00 86.98  ? 701 NAG B C8  1 
HETATM 4567 N N2  . NAG I 5 .   ? 161.738 132.299 151.962 1.00 86.98  ? 701 NAG B N2  1 
HETATM 4568 O O3  . NAG I 5 .   ? 164.824 130.375 151.588 1.00 86.98  ? 701 NAG B O3  1 
HETATM 4569 O O4  . NAG I 5 .   ? 164.213 133.939 152.075 1.00 86.98  ? 701 NAG B O4  1 
HETATM 4570 O O5  . NAG I 5 .   ? 164.133 131.862 149.381 1.00 86.98  ? 701 NAG B O5  1 
HETATM 4571 O O6  . NAG I 5 .   ? 166.286 132.243 148.156 1.00 86.98  ? 701 NAG B O6  1 
HETATM 4572 O O7  . NAG I 5 .   ? 160.155 130.722 152.150 1.00 86.98  ? 701 NAG B O7  1 
HETATM 4573 C C1  . NAG J 5 .   ? 139.200 172.499 142.668 1.00 81.62  ? 702 NAG B C1  1 
HETATM 4574 C C2  . NAG J 5 .   ? 138.405 173.559 143.434 1.00 81.62  ? 702 NAG B C2  1 
HETATM 4575 C C3  . NAG J 5 .   ? 139.278 174.780 143.713 1.00 81.62  ? 702 NAG B C3  1 
HETATM 4576 C C4  . NAG J 5 .   ? 140.567 174.364 144.408 1.00 81.62  ? 702 NAG B C4  1 
HETATM 4577 C C5  . NAG J 5 .   ? 141.273 173.273 143.606 1.00 81.62  ? 702 NAG B C5  1 
HETATM 4578 C C6  . NAG J 5 .   ? 142.499 172.729 144.301 1.00 81.62  ? 702 NAG B C6  1 
HETATM 4579 C C7  . NAG J 5 .   ? 137.163 174.478 141.500 1.00 81.62  ? 702 NAG B C7  1 
HETATM 4580 C C8  . NAG J 5 .   ? 135.802 174.790 140.955 1.00 81.62  ? 702 NAG B C8  1 
HETATM 4581 N N2  . NAG J 5 .   ? 137.190 173.936 142.726 1.00 81.62  ? 702 NAG B N2  1 
HETATM 4582 O O3  . NAG J 5 .   ? 138.560 175.699 144.530 1.00 81.62  ? 702 NAG B O3  1 
HETATM 4583 O O4  . NAG J 5 .   ? 141.434 175.484 144.538 1.00 81.62  ? 702 NAG B O4  1 
HETATM 4584 O O5  . NAG J 5 .   ? 140.385 172.163 143.401 1.00 81.62  ? 702 NAG B O5  1 
HETATM 4585 O O6  . NAG J 5 .   ? 143.327 172.003 143.402 1.00 81.62  ? 702 NAG B O6  1 
HETATM 4586 O O7  . NAG J 5 .   ? 138.186 174.709 140.860 1.00 81.62  ? 702 NAG B O7  1 
HETATM 4587 C C1  . NAG K 5 .   ? 177.847 165.353 165.731 1.00 82.12  ? 801 NAG C C1  1 
HETATM 4588 C C2  . NAG K 5 .   ? 178.506 164.436 166.761 1.00 82.12  ? 801 NAG C C2  1 
HETATM 4589 C C3  . NAG K 5 .   ? 177.766 163.096 166.842 1.00 82.12  ? 801 NAG C C3  1 
HETATM 4590 C C4  . NAG K 5 .   ? 177.245 162.650 165.478 1.00 82.12  ? 801 NAG C C4  1 
HETATM 4591 C C5  . NAG K 5 .   ? 176.404 163.736 164.807 1.00 82.12  ? 801 NAG C C5  1 
HETATM 4592 C C6  . NAG K 5 .   ? 174.936 163.385 164.732 0.10 82.12  ? 801 NAG C C6  1 
HETATM 4593 C C7  . NAG K 5 .   ? 180.819 163.880 167.369 0.10 82.12  ? 801 NAG C C7  1 
HETATM 4594 C C8  . NAG K 5 .   ? 182.222 163.705 166.873 0.10 82.12  ? 801 NAG C C8  1 
HETATM 4595 N N2  . NAG K 5 .   ? 179.911 164.226 166.451 0.10 82.12  ? 801 NAG C N2  1 
HETATM 4596 O O3  . NAG K 5 .   ? 176.686 163.208 167.761 1.00 82.12  ? 801 NAG C O3  1 
HETATM 4597 O O4  . NAG K 5 .   ? 178.336 162.312 164.628 1.00 82.12  ? 801 NAG C O4  1 
HETATM 4598 O O5  . NAG K 5 .   ? 176.500 164.963 165.541 1.00 82.12  ? 801 NAG C O5  1 
HETATM 4599 O O6  . NAG K 5 .   ? 174.457 163.441 163.395 0.10 82.12  ? 801 NAG C O6  1 
HETATM 4600 O O7  . NAG K 5 .   ? 180.521 163.717 168.549 0.10 82.12  ? 801 NAG C O7  1 
# 
