data_8V2A
# 
_entry.id   8V2A 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8V2A         pdb_00008v2a 10.2210/pdb8v2a/pdb 
WWPDB D_1000278757 ?            ?                   
EMDB  EMD-42903    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8V2A 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human type I OSM receptor complex: model for assembly core region' 
_pdbx_database_related.db_id          EMD-42903 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              matthew.franklin@regeneron.com 
_pdbx_contact_author.name_first         Matthew 
_pdbx_contact_author.name_last          Franklin 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1482-0136 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhou, Y.'       1 ? 
'Franklin, M.C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9776 
_citation.page_last                 9776 
_citation.title                     
'Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54124-1 
_citation.pdbx_database_id_PubMed   39532904 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhou, Y.'       1 0000-0002-1650-4591 
primary 'Stevis, P.E.'   2 ?                   
primary 'Cao, J.'        3 ?                   
primary 'Ehrlich, G.'    4 ?                   
primary 'Jones, J.'      5 ?                   
primary 'Rafique, A.'    6 0000-0003-4078-7242 
primary 'Sleeman, M.W.'  7 ?                   
primary 'Olson, W.C.'    8 ?                   
primary 'Franklin, M.C.' 9 0000-0002-1482-0136 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Oncostatin-M                                                                              22186.369 1 ? ? ? ? 
2 polymer     man 'Interleukin-6 receptor subunit beta'                                                     71233.203 1 ? ? ? ? 
3 polymer     man 'Leukemia inhibitory factor receptor'                                                     92834.812 1 ? ? ? ? 
4 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   3 ? ? ? ? 
5 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose                                                  221.208   4 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
2 
;IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha
;
3 'LIF receptor,LIF-R' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGC
VLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAF
QRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRR
;
;AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGC
VLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAF
QRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRR
;
A ? 
2 'polypeptide(L)' no no 
;ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLT
CNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSC
TVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYR
TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ
GYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD
GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSL
TSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEEQKLISEEDLGGEQKLISEEDLHHHHHH
;
;ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLT
CNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSC
TVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYR
TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ
GYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD
GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSL
TSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEEQKLISEEDLGGEQKLISEEDLHHHHHH
;
B ? 
3 'polypeptide(L)' no no 
;QKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSK
FTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWS
WASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGH
TNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGP
RATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDI
NSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSN
KKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYI
ISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTET
VIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFG
KGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSEQKLISEEDLG
GEQKLISEEDLHHHHHH
;
;QKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSK
FTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWS
WASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGH
TNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGP
RATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDI
NSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSN
KKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYI
ISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTET
VIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFG
KGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSEQKLISEEDLG
GEQKLISEEDLHHHHHH
;
C ? 
# 
_pdbx_entity_nonpoly.entity_id   5 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   ALA n 
1 3   ILE n 
1 4   GLY n 
1 5   SER n 
1 6   CYS n 
1 7   SER n 
1 8   LYS n 
1 9   GLU n 
1 10  TYR n 
1 11  ARG n 
1 12  VAL n 
1 13  LEU n 
1 14  LEU n 
1 15  GLY n 
1 16  GLN n 
1 17  LEU n 
1 18  GLN n 
1 19  LYS n 
1 20  GLN n 
1 21  THR n 
1 22  ASP n 
1 23  LEU n 
1 24  MET n 
1 25  GLN n 
1 26  ASP n 
1 27  THR n 
1 28  SER n 
1 29  ARG n 
1 30  LEU n 
1 31  LEU n 
1 32  ASP n 
1 33  PRO n 
1 34  TYR n 
1 35  ILE n 
1 36  ARG n 
1 37  ILE n 
1 38  GLN n 
1 39  GLY n 
1 40  LEU n 
1 41  ASP n 
1 42  VAL n 
1 43  PRO n 
1 44  LYS n 
1 45  LEU n 
1 46  ARG n 
1 47  GLU n 
1 48  HIS n 
1 49  CYS n 
1 50  ARG n 
1 51  GLU n 
1 52  ARG n 
1 53  PRO n 
1 54  GLY n 
1 55  ALA n 
1 56  PHE n 
1 57  PRO n 
1 58  SER n 
1 59  GLU n 
1 60  GLU n 
1 61  THR n 
1 62  LEU n 
1 63  ARG n 
1 64  GLY n 
1 65  LEU n 
1 66  GLY n 
1 67  ARG n 
1 68  ARG n 
1 69  GLY n 
1 70  PHE n 
1 71  LEU n 
1 72  GLN n 
1 73  THR n 
1 74  LEU n 
1 75  ASN n 
1 76  ALA n 
1 77  THR n 
1 78  LEU n 
1 79  GLY n 
1 80  CYS n 
1 81  VAL n 
1 82  LEU n 
1 83  HIS n 
1 84  ARG n 
1 85  LEU n 
1 86  ALA n 
1 87  ASP n 
1 88  LEU n 
1 89  GLU n 
1 90  GLN n 
1 91  ARG n 
1 92  LEU n 
1 93  PRO n 
1 94  LYS n 
1 95  ALA n 
1 96  GLN n 
1 97  ASP n 
1 98  LEU n 
1 99  GLU n 
1 100 ARG n 
1 101 SER n 
1 102 GLY n 
1 103 LEU n 
1 104 ASN n 
1 105 ILE n 
1 106 GLU n 
1 107 ASP n 
1 108 LEU n 
1 109 GLU n 
1 110 LYS n 
1 111 LEU n 
1 112 GLN n 
1 113 MET n 
1 114 ALA n 
1 115 ARG n 
1 116 PRO n 
1 117 ASN n 
1 118 ILE n 
1 119 LEU n 
1 120 GLY n 
1 121 LEU n 
1 122 ARG n 
1 123 ASN n 
1 124 ASN n 
1 125 ILE n 
1 126 TYR n 
1 127 CYS n 
1 128 MET n 
1 129 ALA n 
1 130 GLN n 
1 131 LEU n 
1 132 LEU n 
1 133 ASP n 
1 134 ASN n 
1 135 SER n 
1 136 ASP n 
1 137 THR n 
1 138 ALA n 
1 139 GLU n 
1 140 PRO n 
1 141 THR n 
1 142 LYS n 
1 143 ALA n 
1 144 GLY n 
1 145 ARG n 
1 146 GLY n 
1 147 ALA n 
1 148 SER n 
1 149 GLN n 
1 150 PRO n 
1 151 PRO n 
1 152 THR n 
1 153 PRO n 
1 154 THR n 
1 155 PRO n 
1 156 ALA n 
1 157 SER n 
1 158 ASP n 
1 159 ALA n 
1 160 PHE n 
1 161 GLN n 
1 162 ARG n 
1 163 LYS n 
1 164 LEU n 
1 165 GLU n 
1 166 GLY n 
1 167 CYS n 
1 168 ARG n 
1 169 PHE n 
1 170 LEU n 
1 171 HIS n 
1 172 GLY n 
1 173 TYR n 
1 174 HIS n 
1 175 ARG n 
1 176 PHE n 
1 177 MET n 
1 178 HIS n 
1 179 SER n 
1 180 VAL n 
1 181 GLY n 
1 182 ARG n 
1 183 VAL n 
1 184 PHE n 
1 185 SER n 
1 186 LYS n 
1 187 TRP n 
1 188 GLY n 
1 189 GLU n 
1 190 SER n 
1 191 PRO n 
1 192 ASN n 
1 193 ARG n 
1 194 SER n 
1 195 ARG n 
1 196 ARG n 
2 1   GLU n 
2 2   LEU n 
2 3   LEU n 
2 4   ASP n 
2 5   PRO n 
2 6   CYS n 
2 7   GLY n 
2 8   TYR n 
2 9   ILE n 
2 10  SER n 
2 11  PRO n 
2 12  GLU n 
2 13  SER n 
2 14  PRO n 
2 15  VAL n 
2 16  VAL n 
2 17  GLN n 
2 18  LEU n 
2 19  HIS n 
2 20  SER n 
2 21  ASN n 
2 22  PHE n 
2 23  THR n 
2 24  ALA n 
2 25  VAL n 
2 26  CYS n 
2 27  VAL n 
2 28  LEU n 
2 29  LYS n 
2 30  GLU n 
2 31  LYS n 
2 32  CYS n 
2 33  MET n 
2 34  ASP n 
2 35  TYR n 
2 36  PHE n 
2 37  HIS n 
2 38  VAL n 
2 39  ASN n 
2 40  ALA n 
2 41  ASN n 
2 42  TYR n 
2 43  ILE n 
2 44  VAL n 
2 45  TRP n 
2 46  LYS n 
2 47  THR n 
2 48  ASN n 
2 49  HIS n 
2 50  PHE n 
2 51  THR n 
2 52  ILE n 
2 53  PRO n 
2 54  LYS n 
2 55  GLU n 
2 56  GLN n 
2 57  TYR n 
2 58  THR n 
2 59  ILE n 
2 60  ILE n 
2 61  ASN n 
2 62  ARG n 
2 63  THR n 
2 64  ALA n 
2 65  SER n 
2 66  SER n 
2 67  VAL n 
2 68  THR n 
2 69  PHE n 
2 70  THR n 
2 71  ASP n 
2 72  ILE n 
2 73  ALA n 
2 74  SER n 
2 75  LEU n 
2 76  ASN n 
2 77  ILE n 
2 78  GLN n 
2 79  LEU n 
2 80  THR n 
2 81  CYS n 
2 82  ASN n 
2 83  ILE n 
2 84  LEU n 
2 85  THR n 
2 86  PHE n 
2 87  GLY n 
2 88  GLN n 
2 89  LEU n 
2 90  GLU n 
2 91  GLN n 
2 92  ASN n 
2 93  VAL n 
2 94  TYR n 
2 95  GLY n 
2 96  ILE n 
2 97  THR n 
2 98  ILE n 
2 99  ILE n 
2 100 SER n 
2 101 GLY n 
2 102 LEU n 
2 103 PRO n 
2 104 PRO n 
2 105 GLU n 
2 106 LYS n 
2 107 PRO n 
2 108 LYS n 
2 109 ASN n 
2 110 LEU n 
2 111 SER n 
2 112 CYS n 
2 113 ILE n 
2 114 VAL n 
2 115 ASN n 
2 116 GLU n 
2 117 GLY n 
2 118 LYS n 
2 119 LYS n 
2 120 MET n 
2 121 ARG n 
2 122 CYS n 
2 123 GLU n 
2 124 TRP n 
2 125 ASP n 
2 126 GLY n 
2 127 GLY n 
2 128 ARG n 
2 129 GLU n 
2 130 THR n 
2 131 HIS n 
2 132 LEU n 
2 133 GLU n 
2 134 THR n 
2 135 ASN n 
2 136 PHE n 
2 137 THR n 
2 138 LEU n 
2 139 LYS n 
2 140 SER n 
2 141 GLU n 
2 142 TRP n 
2 143 ALA n 
2 144 THR n 
2 145 HIS n 
2 146 LYS n 
2 147 PHE n 
2 148 ALA n 
2 149 ASP n 
2 150 CYS n 
2 151 LYS n 
2 152 ALA n 
2 153 LYS n 
2 154 ARG n 
2 155 ASP n 
2 156 THR n 
2 157 PRO n 
2 158 THR n 
2 159 SER n 
2 160 CYS n 
2 161 THR n 
2 162 VAL n 
2 163 ASP n 
2 164 TYR n 
2 165 SER n 
2 166 THR n 
2 167 VAL n 
2 168 TYR n 
2 169 PHE n 
2 170 VAL n 
2 171 ASN n 
2 172 ILE n 
2 173 GLU n 
2 174 VAL n 
2 175 TRP n 
2 176 VAL n 
2 177 GLU n 
2 178 ALA n 
2 179 GLU n 
2 180 ASN n 
2 181 ALA n 
2 182 LEU n 
2 183 GLY n 
2 184 LYS n 
2 185 VAL n 
2 186 THR n 
2 187 SER n 
2 188 ASP n 
2 189 HIS n 
2 190 ILE n 
2 191 ASN n 
2 192 PHE n 
2 193 ASP n 
2 194 PRO n 
2 195 VAL n 
2 196 TYR n 
2 197 LYS n 
2 198 VAL n 
2 199 LYS n 
2 200 PRO n 
2 201 ASN n 
2 202 PRO n 
2 203 PRO n 
2 204 HIS n 
2 205 ASN n 
2 206 LEU n 
2 207 SER n 
2 208 VAL n 
2 209 ILE n 
2 210 ASN n 
2 211 SER n 
2 212 GLU n 
2 213 GLU n 
2 214 LEU n 
2 215 SER n 
2 216 SER n 
2 217 ILE n 
2 218 LEU n 
2 219 LYS n 
2 220 LEU n 
2 221 THR n 
2 222 TRP n 
2 223 THR n 
2 224 ASN n 
2 225 PRO n 
2 226 SER n 
2 227 ILE n 
2 228 LYS n 
2 229 SER n 
2 230 VAL n 
2 231 ILE n 
2 232 ILE n 
2 233 LEU n 
2 234 LYS n 
2 235 TYR n 
2 236 ASN n 
2 237 ILE n 
2 238 GLN n 
2 239 TYR n 
2 240 ARG n 
2 241 THR n 
2 242 LYS n 
2 243 ASP n 
2 244 ALA n 
2 245 SER n 
2 246 THR n 
2 247 TRP n 
2 248 SER n 
2 249 GLN n 
2 250 ILE n 
2 251 PRO n 
2 252 PRO n 
2 253 GLU n 
2 254 ASP n 
2 255 THR n 
2 256 ALA n 
2 257 SER n 
2 258 THR n 
2 259 ARG n 
2 260 SER n 
2 261 SER n 
2 262 PHE n 
2 263 THR n 
2 264 VAL n 
2 265 GLN n 
2 266 ASP n 
2 267 LEU n 
2 268 LYS n 
2 269 PRO n 
2 270 PHE n 
2 271 THR n 
2 272 GLU n 
2 273 TYR n 
2 274 VAL n 
2 275 PHE n 
2 276 ARG n 
2 277 ILE n 
2 278 ARG n 
2 279 CYS n 
2 280 MET n 
2 281 LYS n 
2 282 GLU n 
2 283 ASP n 
2 284 GLY n 
2 285 LYS n 
2 286 GLY n 
2 287 TYR n 
2 288 TRP n 
2 289 SER n 
2 290 ASP n 
2 291 TRP n 
2 292 SER n 
2 293 GLU n 
2 294 GLU n 
2 295 ALA n 
2 296 SER n 
2 297 GLY n 
2 298 ILE n 
2 299 THR n 
2 300 TYR n 
2 301 GLU n 
2 302 ASP n 
2 303 ARG n 
2 304 PRO n 
2 305 SER n 
2 306 LYS n 
2 307 ALA n 
2 308 PRO n 
2 309 SER n 
2 310 PHE n 
2 311 TRP n 
2 312 TYR n 
2 313 LYS n 
2 314 ILE n 
2 315 ASP n 
2 316 PRO n 
2 317 SER n 
2 318 HIS n 
2 319 THR n 
2 320 GLN n 
2 321 GLY n 
2 322 TYR n 
2 323 ARG n 
2 324 THR n 
2 325 VAL n 
2 326 GLN n 
2 327 LEU n 
2 328 VAL n 
2 329 TRP n 
2 330 LYS n 
2 331 THR n 
2 332 LEU n 
2 333 PRO n 
2 334 PRO n 
2 335 PHE n 
2 336 GLU n 
2 337 ALA n 
2 338 ASN n 
2 339 GLY n 
2 340 LYS n 
2 341 ILE n 
2 342 LEU n 
2 343 ASP n 
2 344 TYR n 
2 345 GLU n 
2 346 VAL n 
2 347 THR n 
2 348 LEU n 
2 349 THR n 
2 350 ARG n 
2 351 TRP n 
2 352 LYS n 
2 353 SER n 
2 354 HIS n 
2 355 LEU n 
2 356 GLN n 
2 357 ASN n 
2 358 TYR n 
2 359 THR n 
2 360 VAL n 
2 361 ASN n 
2 362 ALA n 
2 363 THR n 
2 364 LYS n 
2 365 LEU n 
2 366 THR n 
2 367 VAL n 
2 368 ASN n 
2 369 LEU n 
2 370 THR n 
2 371 ASN n 
2 372 ASP n 
2 373 ARG n 
2 374 TYR n 
2 375 LEU n 
2 376 ALA n 
2 377 THR n 
2 378 LEU n 
2 379 THR n 
2 380 VAL n 
2 381 ARG n 
2 382 ASN n 
2 383 LEU n 
2 384 VAL n 
2 385 GLY n 
2 386 LYS n 
2 387 SER n 
2 388 ASP n 
2 389 ALA n 
2 390 ALA n 
2 391 VAL n 
2 392 LEU n 
2 393 THR n 
2 394 ILE n 
2 395 PRO n 
2 396 ALA n 
2 397 CYS n 
2 398 ASP n 
2 399 PHE n 
2 400 GLN n 
2 401 ALA n 
2 402 THR n 
2 403 HIS n 
2 404 PRO n 
2 405 VAL n 
2 406 MET n 
2 407 ASP n 
2 408 LEU n 
2 409 LYS n 
2 410 ALA n 
2 411 PHE n 
2 412 PRO n 
2 413 LYS n 
2 414 ASP n 
2 415 ASN n 
2 416 MET n 
2 417 LEU n 
2 418 TRP n 
2 419 VAL n 
2 420 GLU n 
2 421 TRP n 
2 422 THR n 
2 423 THR n 
2 424 PRO n 
2 425 ARG n 
2 426 GLU n 
2 427 SER n 
2 428 VAL n 
2 429 LYS n 
2 430 LYS n 
2 431 TYR n 
2 432 ILE n 
2 433 LEU n 
2 434 GLU n 
2 435 TRP n 
2 436 CYS n 
2 437 VAL n 
2 438 LEU n 
2 439 SER n 
2 440 ASP n 
2 441 LYS n 
2 442 ALA n 
2 443 PRO n 
2 444 CYS n 
2 445 ILE n 
2 446 THR n 
2 447 ASP n 
2 448 TRP n 
2 449 GLN n 
2 450 GLN n 
2 451 GLU n 
2 452 ASP n 
2 453 GLY n 
2 454 THR n 
2 455 VAL n 
2 456 HIS n 
2 457 ARG n 
2 458 THR n 
2 459 TYR n 
2 460 LEU n 
2 461 ARG n 
2 462 GLY n 
2 463 ASN n 
2 464 LEU n 
2 465 ALA n 
2 466 GLU n 
2 467 SER n 
2 468 LYS n 
2 469 CYS n 
2 470 TYR n 
2 471 LEU n 
2 472 ILE n 
2 473 THR n 
2 474 VAL n 
2 475 THR n 
2 476 PRO n 
2 477 VAL n 
2 478 TYR n 
2 479 ALA n 
2 480 ASP n 
2 481 GLY n 
2 482 PRO n 
2 483 GLY n 
2 484 SER n 
2 485 PRO n 
2 486 GLU n 
2 487 SER n 
2 488 ILE n 
2 489 LYS n 
2 490 ALA n 
2 491 TYR n 
2 492 LEU n 
2 493 LYS n 
2 494 GLN n 
2 495 ALA n 
2 496 PRO n 
2 497 PRO n 
2 498 SER n 
2 499 LYS n 
2 500 GLY n 
2 501 PRO n 
2 502 THR n 
2 503 VAL n 
2 504 ARG n 
2 505 THR n 
2 506 LYS n 
2 507 LYS n 
2 508 VAL n 
2 509 GLY n 
2 510 LYS n 
2 511 ASN n 
2 512 GLU n 
2 513 ALA n 
2 514 VAL n 
2 515 LEU n 
2 516 GLU n 
2 517 TRP n 
2 518 ASP n 
2 519 GLN n 
2 520 LEU n 
2 521 PRO n 
2 522 VAL n 
2 523 ASP n 
2 524 VAL n 
2 525 GLN n 
2 526 ASN n 
2 527 GLY n 
2 528 PHE n 
2 529 ILE n 
2 530 ARG n 
2 531 ASN n 
2 532 TYR n 
2 533 THR n 
2 534 ILE n 
2 535 PHE n 
2 536 TYR n 
2 537 ARG n 
2 538 THR n 
2 539 ILE n 
2 540 ILE n 
2 541 GLY n 
2 542 ASN n 
2 543 GLU n 
2 544 THR n 
2 545 ALA n 
2 546 VAL n 
2 547 ASN n 
2 548 VAL n 
2 549 ASP n 
2 550 SER n 
2 551 SER n 
2 552 HIS n 
2 553 THR n 
2 554 GLU n 
2 555 TYR n 
2 556 THR n 
2 557 LEU n 
2 558 SER n 
2 559 SER n 
2 560 LEU n 
2 561 THR n 
2 562 SER n 
2 563 ASP n 
2 564 THR n 
2 565 LEU n 
2 566 TYR n 
2 567 MET n 
2 568 VAL n 
2 569 ARG n 
2 570 MET n 
2 571 ALA n 
2 572 ALA n 
2 573 TYR n 
2 574 THR n 
2 575 ASP n 
2 576 GLU n 
2 577 GLY n 
2 578 GLY n 
2 579 LYS n 
2 580 ASP n 
2 581 GLY n 
2 582 PRO n 
2 583 GLU n 
2 584 PHE n 
2 585 THR n 
2 586 PHE n 
2 587 THR n 
2 588 THR n 
2 589 PRO n 
2 590 LYS n 
2 591 PHE n 
2 592 ALA n 
2 593 GLN n 
2 594 GLY n 
2 595 GLU n 
2 596 ILE n 
2 597 GLU n 
2 598 GLU n 
2 599 GLN n 
2 600 LYS n 
2 601 LEU n 
2 602 ILE n 
2 603 SER n 
2 604 GLU n 
2 605 GLU n 
2 606 ASP n 
2 607 LEU n 
2 608 GLY n 
2 609 GLY n 
2 610 GLU n 
2 611 GLN n 
2 612 LYS n 
2 613 LEU n 
2 614 ILE n 
2 615 SER n 
2 616 GLU n 
2 617 GLU n 
2 618 ASP n 
2 619 LEU n 
2 620 HIS n 
2 621 HIS n 
2 622 HIS n 
2 623 HIS n 
2 624 HIS n 
2 625 HIS n 
3 1   GLN n 
3 2   LYS n 
3 3   LYS n 
3 4   GLY n 
3 5   ALA n 
3 6   PRO n 
3 7   HIS n 
3 8   ASP n 
3 9   LEU n 
3 10  LYS n 
3 11  CYS n 
3 12  VAL n 
3 13  THR n 
3 14  ASN n 
3 15  ASN n 
3 16  LEU n 
3 17  GLN n 
3 18  VAL n 
3 19  TRP n 
3 20  ASN n 
3 21  CYS n 
3 22  SER n 
3 23  TRP n 
3 24  LYS n 
3 25  ALA n 
3 26  PRO n 
3 27  SER n 
3 28  GLY n 
3 29  THR n 
3 30  GLY n 
3 31  ARG n 
3 32  GLY n 
3 33  THR n 
3 34  ASP n 
3 35  TYR n 
3 36  GLU n 
3 37  VAL n 
3 38  CYS n 
3 39  ILE n 
3 40  GLU n 
3 41  ASN n 
3 42  ARG n 
3 43  SER n 
3 44  ARG n 
3 45  SER n 
3 46  CYS n 
3 47  TYR n 
3 48  GLN n 
3 49  LEU n 
3 50  GLU n 
3 51  LYS n 
3 52  THR n 
3 53  SER n 
3 54  ILE n 
3 55  LYS n 
3 56  ILE n 
3 57  PRO n 
3 58  ALA n 
3 59  LEU n 
3 60  SER n 
3 61  HIS n 
3 62  GLY n 
3 63  ASP n 
3 64  TYR n 
3 65  GLU n 
3 66  ILE n 
3 67  THR n 
3 68  ILE n 
3 69  ASN n 
3 70  SER n 
3 71  LEU n 
3 72  HIS n 
3 73  ASP n 
3 74  PHE n 
3 75  GLY n 
3 76  SER n 
3 77  SER n 
3 78  THR n 
3 79  SER n 
3 80  LYS n 
3 81  PHE n 
3 82  THR n 
3 83  LEU n 
3 84  ASN n 
3 85  GLU n 
3 86  GLN n 
3 87  ASN n 
3 88  VAL n 
3 89  SER n 
3 90  LEU n 
3 91  ILE n 
3 92  PRO n 
3 93  ASP n 
3 94  THR n 
3 95  PRO n 
3 96  GLU n 
3 97  ILE n 
3 98  LEU n 
3 99  ASN n 
3 100 LEU n 
3 101 SER n 
3 102 ALA n 
3 103 ASP n 
3 104 PHE n 
3 105 SER n 
3 106 THR n 
3 107 SER n 
3 108 THR n 
3 109 LEU n 
3 110 TYR n 
3 111 LEU n 
3 112 LYS n 
3 113 TRP n 
3 114 ASN n 
3 115 ASP n 
3 116 ARG n 
3 117 GLY n 
3 118 SER n 
3 119 VAL n 
3 120 PHE n 
3 121 PRO n 
3 122 HIS n 
3 123 ARG n 
3 124 SER n 
3 125 ASN n 
3 126 VAL n 
3 127 ILE n 
3 128 TRP n 
3 129 GLU n 
3 130 ILE n 
3 131 LYS n 
3 132 VAL n 
3 133 LEU n 
3 134 ARG n 
3 135 LYS n 
3 136 GLU n 
3 137 SER n 
3 138 MET n 
3 139 GLU n 
3 140 LEU n 
3 141 VAL n 
3 142 LYS n 
3 143 LEU n 
3 144 VAL n 
3 145 THR n 
3 146 HIS n 
3 147 ASN n 
3 148 THR n 
3 149 THR n 
3 150 LEU n 
3 151 ASN n 
3 152 GLY n 
3 153 LYS n 
3 154 ASP n 
3 155 THR n 
3 156 LEU n 
3 157 HIS n 
3 158 HIS n 
3 159 TRP n 
3 160 SER n 
3 161 TRP n 
3 162 ALA n 
3 163 SER n 
3 164 ASP n 
3 165 MET n 
3 166 PRO n 
3 167 LEU n 
3 168 GLU n 
3 169 CYS n 
3 170 ALA n 
3 171 ILE n 
3 172 HIS n 
3 173 PHE n 
3 174 VAL n 
3 175 GLU n 
3 176 ILE n 
3 177 ARG n 
3 178 CYS n 
3 179 TYR n 
3 180 ILE n 
3 181 ASP n 
3 182 ASN n 
3 183 LEU n 
3 184 HIS n 
3 185 PHE n 
3 186 SER n 
3 187 GLY n 
3 188 LEU n 
3 189 GLU n 
3 190 GLU n 
3 191 TRP n 
3 192 SER n 
3 193 ASP n 
3 194 TRP n 
3 195 SER n 
3 196 PRO n 
3 197 VAL n 
3 198 LYS n 
3 199 ASN n 
3 200 ILE n 
3 201 SER n 
3 202 TRP n 
3 203 ILE n 
3 204 PRO n 
3 205 ASP n 
3 206 SER n 
3 207 GLN n 
3 208 THR n 
3 209 LYS n 
3 210 VAL n 
3 211 PHE n 
3 212 PRO n 
3 213 GLN n 
3 214 ASP n 
3 215 LYS n 
3 216 VAL n 
3 217 ILE n 
3 218 LEU n 
3 219 VAL n 
3 220 GLY n 
3 221 SER n 
3 222 ASP n 
3 223 ILE n 
3 224 THR n 
3 225 PHE n 
3 226 CYS n 
3 227 CYS n 
3 228 VAL n 
3 229 SER n 
3 230 GLN n 
3 231 GLU n 
3 232 LYS n 
3 233 VAL n 
3 234 LEU n 
3 235 SER n 
3 236 ALA n 
3 237 LEU n 
3 238 ILE n 
3 239 GLY n 
3 240 HIS n 
3 241 THR n 
3 242 ASN n 
3 243 CYS n 
3 244 PRO n 
3 245 LEU n 
3 246 ILE n 
3 247 HIS n 
3 248 LEU n 
3 249 ASP n 
3 250 GLY n 
3 251 GLU n 
3 252 ASN n 
3 253 VAL n 
3 254 ALA n 
3 255 ILE n 
3 256 LYS n 
3 257 ILE n 
3 258 ARG n 
3 259 ASN n 
3 260 ILE n 
3 261 SER n 
3 262 VAL n 
3 263 SER n 
3 264 ALA n 
3 265 SER n 
3 266 SER n 
3 267 GLY n 
3 268 THR n 
3 269 ASN n 
3 270 VAL n 
3 271 VAL n 
3 272 PHE n 
3 273 THR n 
3 274 THR n 
3 275 GLU n 
3 276 ASP n 
3 277 ASN n 
3 278 ILE n 
3 279 PHE n 
3 280 GLY n 
3 281 THR n 
3 282 VAL n 
3 283 ILE n 
3 284 PHE n 
3 285 ALA n 
3 286 GLY n 
3 287 TYR n 
3 288 PRO n 
3 289 PRO n 
3 290 ASP n 
3 291 THR n 
3 292 PRO n 
3 293 GLN n 
3 294 GLN n 
3 295 LEU n 
3 296 ASN n 
3 297 CYS n 
3 298 GLU n 
3 299 THR n 
3 300 HIS n 
3 301 ASP n 
3 302 LEU n 
3 303 LYS n 
3 304 GLU n 
3 305 ILE n 
3 306 ILE n 
3 307 CYS n 
3 308 SER n 
3 309 TRP n 
3 310 ASN n 
3 311 PRO n 
3 312 GLY n 
3 313 ARG n 
3 314 VAL n 
3 315 THR n 
3 316 ALA n 
3 317 LEU n 
3 318 VAL n 
3 319 GLY n 
3 320 PRO n 
3 321 ARG n 
3 322 ALA n 
3 323 THR n 
3 324 SER n 
3 325 TYR n 
3 326 THR n 
3 327 LEU n 
3 328 VAL n 
3 329 GLU n 
3 330 SER n 
3 331 PHE n 
3 332 SER n 
3 333 GLY n 
3 334 LYS n 
3 335 TYR n 
3 336 VAL n 
3 337 ARG n 
3 338 LEU n 
3 339 LYS n 
3 340 ARG n 
3 341 ALA n 
3 342 GLU n 
3 343 ALA n 
3 344 PRO n 
3 345 THR n 
3 346 ASN n 
3 347 GLU n 
3 348 SER n 
3 349 TYR n 
3 350 GLN n 
3 351 LEU n 
3 352 LEU n 
3 353 PHE n 
3 354 GLN n 
3 355 MET n 
3 356 LEU n 
3 357 PRO n 
3 358 ASN n 
3 359 GLN n 
3 360 GLU n 
3 361 ILE n 
3 362 TYR n 
3 363 ASN n 
3 364 PHE n 
3 365 THR n 
3 366 LEU n 
3 367 ASN n 
3 368 ALA n 
3 369 HIS n 
3 370 ASN n 
3 371 PRO n 
3 372 LEU n 
3 373 GLY n 
3 374 ARG n 
3 375 SER n 
3 376 GLN n 
3 377 SER n 
3 378 THR n 
3 379 ILE n 
3 380 LEU n 
3 381 VAL n 
3 382 ASN n 
3 383 ILE n 
3 384 THR n 
3 385 GLU n 
3 386 LYS n 
3 387 VAL n 
3 388 TYR n 
3 389 PRO n 
3 390 HIS n 
3 391 THR n 
3 392 PRO n 
3 393 THR n 
3 394 SER n 
3 395 PHE n 
3 396 LYS n 
3 397 VAL n 
3 398 LYS n 
3 399 ASP n 
3 400 ILE n 
3 401 ASN n 
3 402 SER n 
3 403 THR n 
3 404 ALA n 
3 405 VAL n 
3 406 LYS n 
3 407 LEU n 
3 408 SER n 
3 409 TRP n 
3 410 HIS n 
3 411 LEU n 
3 412 PRO n 
3 413 GLY n 
3 414 ASN n 
3 415 PHE n 
3 416 ALA n 
3 417 LYS n 
3 418 ILE n 
3 419 ASN n 
3 420 PHE n 
3 421 LEU n 
3 422 CYS n 
3 423 GLU n 
3 424 ILE n 
3 425 GLU n 
3 426 ILE n 
3 427 LYS n 
3 428 LYS n 
3 429 SER n 
3 430 ASN n 
3 431 SER n 
3 432 VAL n 
3 433 GLN n 
3 434 GLU n 
3 435 GLN n 
3 436 ARG n 
3 437 ASN n 
3 438 VAL n 
3 439 THR n 
3 440 ILE n 
3 441 LYS n 
3 442 GLY n 
3 443 VAL n 
3 444 GLU n 
3 445 ASN n 
3 446 SER n 
3 447 SER n 
3 448 TYR n 
3 449 LEU n 
3 450 VAL n 
3 451 ALA n 
3 452 LEU n 
3 453 ASP n 
3 454 LYS n 
3 455 LEU n 
3 456 ASN n 
3 457 PRO n 
3 458 TYR n 
3 459 THR n 
3 460 LEU n 
3 461 TYR n 
3 462 THR n 
3 463 PHE n 
3 464 ARG n 
3 465 ILE n 
3 466 ARG n 
3 467 CYS n 
3 468 SER n 
3 469 THR n 
3 470 GLU n 
3 471 THR n 
3 472 PHE n 
3 473 TRP n 
3 474 LYS n 
3 475 TRP n 
3 476 SER n 
3 477 LYS n 
3 478 TRP n 
3 479 SER n 
3 480 ASN n 
3 481 LYS n 
3 482 LYS n 
3 483 GLN n 
3 484 HIS n 
3 485 LEU n 
3 486 THR n 
3 487 THR n 
3 488 GLU n 
3 489 ALA n 
3 490 SER n 
3 491 PRO n 
3 492 SER n 
3 493 LYS n 
3 494 GLY n 
3 495 PRO n 
3 496 ASP n 
3 497 THR n 
3 498 TRP n 
3 499 ARG n 
3 500 GLU n 
3 501 TRP n 
3 502 SER n 
3 503 SER n 
3 504 ASP n 
3 505 GLY n 
3 506 LYS n 
3 507 ASN n 
3 508 LEU n 
3 509 ILE n 
3 510 ILE n 
3 511 TYR n 
3 512 TRP n 
3 513 LYS n 
3 514 PRO n 
3 515 LEU n 
3 516 PRO n 
3 517 ILE n 
3 518 ASN n 
3 519 GLU n 
3 520 ALA n 
3 521 ASN n 
3 522 GLY n 
3 523 LYS n 
3 524 ILE n 
3 525 LEU n 
3 526 SER n 
3 527 TYR n 
3 528 ASN n 
3 529 VAL n 
3 530 SER n 
3 531 CYS n 
3 532 SER n 
3 533 SER n 
3 534 ASP n 
3 535 GLU n 
3 536 GLU n 
3 537 THR n 
3 538 GLN n 
3 539 SER n 
3 540 LEU n 
3 541 SER n 
3 542 GLU n 
3 543 ILE n 
3 544 PRO n 
3 545 ASP n 
3 546 PRO n 
3 547 GLN n 
3 548 HIS n 
3 549 LYS n 
3 550 ALA n 
3 551 GLU n 
3 552 ILE n 
3 553 ARG n 
3 554 LEU n 
3 555 ASP n 
3 556 LYS n 
3 557 ASN n 
3 558 ASP n 
3 559 TYR n 
3 560 ILE n 
3 561 ILE n 
3 562 SER n 
3 563 VAL n 
3 564 VAL n 
3 565 ALA n 
3 566 LYS n 
3 567 ASN n 
3 568 SER n 
3 569 VAL n 
3 570 GLY n 
3 571 SER n 
3 572 SER n 
3 573 PRO n 
3 574 PRO n 
3 575 SER n 
3 576 LYS n 
3 577 ILE n 
3 578 ALA n 
3 579 SER n 
3 580 MET n 
3 581 GLU n 
3 582 ILE n 
3 583 PRO n 
3 584 ASN n 
3 585 ASP n 
3 586 ASP n 
3 587 LEU n 
3 588 LYS n 
3 589 ILE n 
3 590 GLU n 
3 591 GLN n 
3 592 VAL n 
3 593 VAL n 
3 594 GLY n 
3 595 MET n 
3 596 GLY n 
3 597 LYS n 
3 598 GLY n 
3 599 ILE n 
3 600 LEU n 
3 601 LEU n 
3 602 THR n 
3 603 TRP n 
3 604 HIS n 
3 605 TYR n 
3 606 ASP n 
3 607 PRO n 
3 608 ASN n 
3 609 MET n 
3 610 THR n 
3 611 CYS n 
3 612 ASP n 
3 613 TYR n 
3 614 VAL n 
3 615 ILE n 
3 616 LYS n 
3 617 TRP n 
3 618 CYS n 
3 619 ASN n 
3 620 SER n 
3 621 SER n 
3 622 ARG n 
3 623 SER n 
3 624 GLU n 
3 625 PRO n 
3 626 CYS n 
3 627 LEU n 
3 628 MET n 
3 629 ASP n 
3 630 TRP n 
3 631 ARG n 
3 632 LYS n 
3 633 VAL n 
3 634 PRO n 
3 635 SER n 
3 636 ASN n 
3 637 SER n 
3 638 THR n 
3 639 GLU n 
3 640 THR n 
3 641 VAL n 
3 642 ILE n 
3 643 GLU n 
3 644 SER n 
3 645 ASP n 
3 646 GLU n 
3 647 PHE n 
3 648 ARG n 
3 649 PRO n 
3 650 GLY n 
3 651 ILE n 
3 652 ARG n 
3 653 TYR n 
3 654 ASN n 
3 655 PHE n 
3 656 PHE n 
3 657 LEU n 
3 658 TYR n 
3 659 GLY n 
3 660 CYS n 
3 661 ARG n 
3 662 ASN n 
3 663 GLN n 
3 664 GLY n 
3 665 TYR n 
3 666 GLN n 
3 667 LEU n 
3 668 LEU n 
3 669 ARG n 
3 670 SER n 
3 671 MET n 
3 672 ILE n 
3 673 GLY n 
3 674 TYR n 
3 675 ILE n 
3 676 GLU n 
3 677 GLU n 
3 678 LEU n 
3 679 ALA n 
3 680 PRO n 
3 681 ILE n 
3 682 VAL n 
3 683 ALA n 
3 684 PRO n 
3 685 ASN n 
3 686 PHE n 
3 687 THR n 
3 688 VAL n 
3 689 GLU n 
3 690 ASP n 
3 691 THR n 
3 692 SER n 
3 693 ALA n 
3 694 ASP n 
3 695 SER n 
3 696 ILE n 
3 697 LEU n 
3 698 VAL n 
3 699 LYS n 
3 700 TRP n 
3 701 GLU n 
3 702 ASP n 
3 703 ILE n 
3 704 PRO n 
3 705 VAL n 
3 706 GLU n 
3 707 GLU n 
3 708 LEU n 
3 709 ARG n 
3 710 GLY n 
3 711 PHE n 
3 712 LEU n 
3 713 ARG n 
3 714 GLY n 
3 715 TYR n 
3 716 LEU n 
3 717 PHE n 
3 718 TYR n 
3 719 PHE n 
3 720 GLY n 
3 721 LYS n 
3 722 GLY n 
3 723 GLU n 
3 724 ARG n 
3 725 ASP n 
3 726 THR n 
3 727 SER n 
3 728 LYS n 
3 729 MET n 
3 730 ARG n 
3 731 VAL n 
3 732 LEU n 
3 733 GLU n 
3 734 SER n 
3 735 GLY n 
3 736 ARG n 
3 737 SER n 
3 738 ASP n 
3 739 ILE n 
3 740 LYS n 
3 741 VAL n 
3 742 LYS n 
3 743 ASN n 
3 744 ILE n 
3 745 THR n 
3 746 ASP n 
3 747 ILE n 
3 748 SER n 
3 749 GLN n 
3 750 LYS n 
3 751 THR n 
3 752 LEU n 
3 753 ARG n 
3 754 ILE n 
3 755 ALA n 
3 756 ASP n 
3 757 LEU n 
3 758 GLN n 
3 759 GLY n 
3 760 LYS n 
3 761 THR n 
3 762 SER n 
3 763 TYR n 
3 764 HIS n 
3 765 LEU n 
3 766 VAL n 
3 767 LEU n 
3 768 ARG n 
3 769 ALA n 
3 770 TYR n 
3 771 THR n 
3 772 ASP n 
3 773 GLY n 
3 774 GLY n 
3 775 VAL n 
3 776 GLY n 
3 777 PRO n 
3 778 GLU n 
3 779 LYS n 
3 780 SER n 
3 781 MET n 
3 782 TYR n 
3 783 VAL n 
3 784 VAL n 
3 785 THR n 
3 786 LYS n 
3 787 GLU n 
3 788 ASN n 
3 789 SER n 
3 790 GLU n 
3 791 GLN n 
3 792 LYS n 
3 793 LEU n 
3 794 ILE n 
3 795 SER n 
3 796 GLU n 
3 797 GLU n 
3 798 ASP n 
3 799 LEU n 
3 800 GLY n 
3 801 GLY n 
3 802 GLU n 
3 803 GLN n 
3 804 LYS n 
3 805 LEU n 
3 806 ILE n 
3 807 SER n 
3 808 GLU n 
3 809 GLU n 
3 810 ASP n 
3 811 LEU n 
3 812 HIS n 
3 813 HIS n 
3 814 HIS n 
3 815 HIS n 
3 816 HIS n 
3 817 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 196 human ? OSM   ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens'       9606  ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 625 human ? IL6ST ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 10029 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 817 human ? LIFR  ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 10029 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   4 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 4 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 4 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 4 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  4 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   26  26  ALA ALA A . n 
A 1 2   ALA 2   27  27  ALA ALA A . n 
A 1 3   ILE 3   28  28  ILE ILE A . n 
A 1 4   GLY 4   29  29  GLY GLY A . n 
A 1 5   SER 5   30  30  SER SER A . n 
A 1 6   CYS 6   31  31  CYS CYS A . n 
A 1 7   SER 7   32  32  SER SER A . n 
A 1 8   LYS 8   33  33  LYS LYS A . n 
A 1 9   GLU 9   34  34  GLU GLU A . n 
A 1 10  TYR 10  35  35  TYR TYR A . n 
A 1 11  ARG 11  36  36  ARG ARG A . n 
A 1 12  VAL 12  37  37  VAL VAL A . n 
A 1 13  LEU 13  38  38  LEU LEU A . n 
A 1 14  LEU 14  39  39  LEU LEU A . n 
A 1 15  GLY 15  40  40  GLY GLY A . n 
A 1 16  GLN 16  41  41  GLN GLN A . n 
A 1 17  LEU 17  42  42  LEU LEU A . n 
A 1 18  GLN 18  43  43  GLN GLN A . n 
A 1 19  LYS 19  44  44  LYS LYS A . n 
A 1 20  GLN 20  45  45  GLN GLN A . n 
A 1 21  THR 21  46  46  THR THR A . n 
A 1 22  ASP 22  47  47  ASP ASP A . n 
A 1 23  LEU 23  48  48  LEU LEU A . n 
A 1 24  MET 24  49  49  MET MET A . n 
A 1 25  GLN 25  50  50  GLN GLN A . n 
A 1 26  ASP 26  51  51  ASP ASP A . n 
A 1 27  THR 27  52  52  THR THR A . n 
A 1 28  SER 28  53  53  SER SER A . n 
A 1 29  ARG 29  54  54  ARG ARG A . n 
A 1 30  LEU 30  55  55  LEU LEU A . n 
A 1 31  LEU 31  56  56  LEU LEU A . n 
A 1 32  ASP 32  57  57  ASP ASP A . n 
A 1 33  PRO 33  58  58  PRO PRO A . n 
A 1 34  TYR 34  59  59  TYR TYR A . n 
A 1 35  ILE 35  60  60  ILE ILE A . n 
A 1 36  ARG 36  61  61  ARG ARG A . n 
A 1 37  ILE 37  62  62  ILE ILE A . n 
A 1 38  GLN 38  63  63  GLN GLN A . n 
A 1 39  GLY 39  64  64  GLY GLY A . n 
A 1 40  LEU 40  65  65  LEU LEU A . n 
A 1 41  ASP 41  66  66  ASP ASP A . n 
A 1 42  VAL 42  67  67  VAL VAL A . n 
A 1 43  PRO 43  68  68  PRO PRO A . n 
A 1 44  LYS 44  69  69  LYS LYS A . n 
A 1 45  LEU 45  70  70  LEU LEU A . n 
A 1 46  ARG 46  71  71  ARG ARG A . n 
A 1 47  GLU 47  72  72  GLU GLU A . n 
A 1 48  HIS 48  73  73  HIS HIS A . n 
A 1 49  CYS 49  74  74  CYS CYS A . n 
A 1 50  ARG 50  75  75  ARG ARG A . n 
A 1 51  GLU 51  76  76  GLU GLU A . n 
A 1 52  ARG 52  77  77  ARG ARG A . n 
A 1 53  PRO 53  78  78  PRO PRO A . n 
A 1 54  GLY 54  79  79  GLY GLY A . n 
A 1 55  ALA 55  80  80  ALA ALA A . n 
A 1 56  PHE 56  81  81  PHE PHE A . n 
A 1 57  PRO 57  82  82  PRO PRO A . n 
A 1 58  SER 58  83  83  SER SER A . n 
A 1 59  GLU 59  84  84  GLU GLU A . n 
A 1 60  GLU 60  85  85  GLU GLU A . n 
A 1 61  THR 61  86  86  THR THR A . n 
A 1 62  LEU 62  87  87  LEU LEU A . n 
A 1 63  ARG 63  88  88  ARG ARG A . n 
A 1 64  GLY 64  89  89  GLY GLY A . n 
A 1 65  LEU 65  90  90  LEU LEU A . n 
A 1 66  GLY 66  91  91  GLY GLY A . n 
A 1 67  ARG 67  92  92  ARG ARG A . n 
A 1 68  ARG 68  93  93  ARG ARG A . n 
A 1 69  GLY 69  94  94  GLY GLY A . n 
A 1 70  PHE 70  95  95  PHE PHE A . n 
A 1 71  LEU 71  96  96  LEU LEU A . n 
A 1 72  GLN 72  97  97  GLN GLN A . n 
A 1 73  THR 73  98  98  THR THR A . n 
A 1 74  LEU 74  99  99  LEU LEU A . n 
A 1 75  ASN 75  100 100 ASN ASN A . n 
A 1 76  ALA 76  101 101 ALA ALA A . n 
A 1 77  THR 77  102 102 THR THR A . n 
A 1 78  LEU 78  103 103 LEU LEU A . n 
A 1 79  GLY 79  104 104 GLY GLY A . n 
A 1 80  CYS 80  105 105 CYS CYS A . n 
A 1 81  VAL 81  106 106 VAL VAL A . n 
A 1 82  LEU 82  107 107 LEU LEU A . n 
A 1 83  HIS 83  108 108 HIS HIS A . n 
A 1 84  ARG 84  109 109 ARG ARG A . n 
A 1 85  LEU 85  110 110 LEU LEU A . n 
A 1 86  ALA 86  111 111 ALA ALA A . n 
A 1 87  ASP 87  112 112 ASP ASP A . n 
A 1 88  LEU 88  113 113 LEU LEU A . n 
A 1 89  GLU 89  114 114 GLU GLU A . n 
A 1 90  GLN 90  115 115 GLN GLN A . n 
A 1 91  ARG 91  116 116 ARG ARG A . n 
A 1 92  LEU 92  117 117 LEU LEU A . n 
A 1 93  PRO 93  118 118 PRO PRO A . n 
A 1 94  LYS 94  119 119 LYS LYS A . n 
A 1 95  ALA 95  120 120 ALA ALA A . n 
A 1 96  GLN 96  121 121 GLN GLN A . n 
A 1 97  ASP 97  122 122 ASP ASP A . n 
A 1 98  LEU 98  123 123 LEU LEU A . n 
A 1 99  GLU 99  124 124 GLU GLU A . n 
A 1 100 ARG 100 125 125 ARG ARG A . n 
A 1 101 SER 101 126 126 SER SER A . n 
A 1 102 GLY 102 127 127 GLY GLY A . n 
A 1 103 LEU 103 128 128 LEU LEU A . n 
A 1 104 ASN 104 129 129 ASN ASN A . n 
A 1 105 ILE 105 130 130 ILE ILE A . n 
A 1 106 GLU 106 131 131 GLU GLU A . n 
A 1 107 ASP 107 132 132 ASP ASP A . n 
A 1 108 LEU 108 133 133 LEU LEU A . n 
A 1 109 GLU 109 134 134 GLU GLU A . n 
A 1 110 LYS 110 135 135 LYS LYS A . n 
A 1 111 LEU 111 136 136 LEU LEU A . n 
A 1 112 GLN 112 137 137 GLN GLN A . n 
A 1 113 MET 113 138 138 MET MET A . n 
A 1 114 ALA 114 139 139 ALA ALA A . n 
A 1 115 ARG 115 140 140 ARG ARG A . n 
A 1 116 PRO 116 141 141 PRO PRO A . n 
A 1 117 ASN 117 142 142 ASN ASN A . n 
A 1 118 ILE 118 143 143 ILE ILE A . n 
A 1 119 LEU 119 144 144 LEU LEU A . n 
A 1 120 GLY 120 145 145 GLY GLY A . n 
A 1 121 LEU 121 146 146 LEU LEU A . n 
A 1 122 ARG 122 147 147 ARG ARG A . n 
A 1 123 ASN 123 148 148 ASN ASN A . n 
A 1 124 ASN 124 149 149 ASN ASN A . n 
A 1 125 ILE 125 150 150 ILE ILE A . n 
A 1 126 TYR 126 151 151 TYR TYR A . n 
A 1 127 CYS 127 152 152 CYS CYS A . n 
A 1 128 MET 128 153 153 MET MET A . n 
A 1 129 ALA 129 154 154 ALA ALA A . n 
A 1 130 GLN 130 155 155 GLN GLN A . n 
A 1 131 LEU 131 156 156 LEU LEU A . n 
A 1 132 LEU 132 157 157 LEU LEU A . n 
A 1 133 ASP 133 158 158 ASP ASP A . n 
A 1 134 ASN 134 159 159 ASN ASN A . n 
A 1 135 SER 135 160 ?   ?   ?   A . n 
A 1 136 ASP 136 161 ?   ?   ?   A . n 
A 1 137 THR 137 162 ?   ?   ?   A . n 
A 1 138 ALA 138 163 ?   ?   ?   A . n 
A 1 139 GLU 139 164 ?   ?   ?   A . n 
A 1 140 PRO 140 165 ?   ?   ?   A . n 
A 1 141 THR 141 166 ?   ?   ?   A . n 
A 1 142 LYS 142 167 ?   ?   ?   A . n 
A 1 143 ALA 143 168 ?   ?   ?   A . n 
A 1 144 GLY 144 169 ?   ?   ?   A . n 
A 1 145 ARG 145 170 ?   ?   ?   A . n 
A 1 146 GLY 146 171 ?   ?   ?   A . n 
A 1 147 ALA 147 172 ?   ?   ?   A . n 
A 1 148 SER 148 173 ?   ?   ?   A . n 
A 1 149 GLN 149 174 ?   ?   ?   A . n 
A 1 150 PRO 150 175 ?   ?   ?   A . n 
A 1 151 PRO 151 176 ?   ?   ?   A . n 
A 1 152 THR 152 177 ?   ?   ?   A . n 
A 1 153 PRO 153 178 ?   ?   ?   A . n 
A 1 154 THR 154 179 179 THR THR A . n 
A 1 155 PRO 155 180 180 PRO PRO A . n 
A 1 156 ALA 156 181 181 ALA ALA A . n 
A 1 157 SER 157 182 182 SER SER A . n 
A 1 158 ASP 158 183 183 ASP ASP A . n 
A 1 159 ALA 159 184 184 ALA ALA A . n 
A 1 160 PHE 160 185 185 PHE PHE A . n 
A 1 161 GLN 161 186 186 GLN GLN A . n 
A 1 162 ARG 162 187 187 ARG ARG A . n 
A 1 163 LYS 163 188 188 LYS LYS A . n 
A 1 164 LEU 164 189 189 LEU LEU A . n 
A 1 165 GLU 165 190 190 GLU GLU A . n 
A 1 166 GLY 166 191 191 GLY GLY A . n 
A 1 167 CYS 167 192 192 CYS CYS A . n 
A 1 168 ARG 168 193 193 ARG ARG A . n 
A 1 169 PHE 169 194 194 PHE PHE A . n 
A 1 170 LEU 170 195 195 LEU LEU A . n 
A 1 171 HIS 171 196 196 HIS HIS A . n 
A 1 172 GLY 172 197 197 GLY GLY A . n 
A 1 173 TYR 173 198 198 TYR TYR A . n 
A 1 174 HIS 174 199 199 HIS HIS A . n 
A 1 175 ARG 175 200 200 ARG ARG A . n 
A 1 176 PHE 176 201 201 PHE PHE A . n 
A 1 177 MET 177 202 202 MET MET A . n 
A 1 178 HIS 178 203 203 HIS HIS A . n 
A 1 179 SER 179 204 204 SER SER A . n 
A 1 180 VAL 180 205 205 VAL VAL A . n 
A 1 181 GLY 181 206 206 GLY GLY A . n 
A 1 182 ARG 182 207 207 ARG ARG A . n 
A 1 183 VAL 183 208 208 VAL VAL A . n 
A 1 184 PHE 184 209 209 PHE PHE A . n 
A 1 185 SER 185 210 210 SER SER A . n 
A 1 186 LYS 186 211 211 LYS LYS A . n 
A 1 187 TRP 187 212 212 TRP TRP A . n 
A 1 188 GLY 188 213 213 GLY GLY A . n 
A 1 189 GLU 189 214 214 GLU GLU A . n 
A 1 190 SER 190 215 215 SER SER A . n 
A 1 191 PRO 191 216 216 PRO PRO A . n 
A 1 192 ASN 192 217 ?   ?   ?   A . n 
A 1 193 ARG 193 218 ?   ?   ?   A . n 
A 1 194 SER 194 219 ?   ?   ?   A . n 
A 1 195 ARG 195 220 ?   ?   ?   A . n 
A 1 196 ARG 196 221 ?   ?   ?   A . n 
B 2 1   GLU 1   23  ?   ?   ?   B . n 
B 2 2   LEU 2   24  ?   ?   ?   B . n 
B 2 3   LEU 3   25  ?   ?   ?   B . n 
B 2 4   ASP 4   26  ?   ?   ?   B . n 
B 2 5   PRO 5   27  ?   ?   ?   B . n 
B 2 6   CYS 6   28  ?   ?   ?   B . n 
B 2 7   GLY 7   29  ?   ?   ?   B . n 
B 2 8   TYR 8   30  ?   ?   ?   B . n 
B 2 9   ILE 9   31  ?   ?   ?   B . n 
B 2 10  SER 10  32  ?   ?   ?   B . n 
B 2 11  PRO 11  33  ?   ?   ?   B . n 
B 2 12  GLU 12  34  ?   ?   ?   B . n 
B 2 13  SER 13  35  ?   ?   ?   B . n 
B 2 14  PRO 14  36  ?   ?   ?   B . n 
B 2 15  VAL 15  37  ?   ?   ?   B . n 
B 2 16  VAL 16  38  ?   ?   ?   B . n 
B 2 17  GLN 17  39  ?   ?   ?   B . n 
B 2 18  LEU 18  40  ?   ?   ?   B . n 
B 2 19  HIS 19  41  ?   ?   ?   B . n 
B 2 20  SER 20  42  ?   ?   ?   B . n 
B 2 21  ASN 21  43  ?   ?   ?   B . n 
B 2 22  PHE 22  44  ?   ?   ?   B . n 
B 2 23  THR 23  45  ?   ?   ?   B . n 
B 2 24  ALA 24  46  ?   ?   ?   B . n 
B 2 25  VAL 25  47  ?   ?   ?   B . n 
B 2 26  CYS 26  48  ?   ?   ?   B . n 
B 2 27  VAL 27  49  ?   ?   ?   B . n 
B 2 28  LEU 28  50  ?   ?   ?   B . n 
B 2 29  LYS 29  51  ?   ?   ?   B . n 
B 2 30  GLU 30  52  ?   ?   ?   B . n 
B 2 31  LYS 31  53  ?   ?   ?   B . n 
B 2 32  CYS 32  54  ?   ?   ?   B . n 
B 2 33  MET 33  55  ?   ?   ?   B . n 
B 2 34  ASP 34  56  ?   ?   ?   B . n 
B 2 35  TYR 35  57  ?   ?   ?   B . n 
B 2 36  PHE 36  58  ?   ?   ?   B . n 
B 2 37  HIS 37  59  ?   ?   ?   B . n 
B 2 38  VAL 38  60  ?   ?   ?   B . n 
B 2 39  ASN 39  61  ?   ?   ?   B . n 
B 2 40  ALA 40  62  ?   ?   ?   B . n 
B 2 41  ASN 41  63  ?   ?   ?   B . n 
B 2 42  TYR 42  64  ?   ?   ?   B . n 
B 2 43  ILE 43  65  ?   ?   ?   B . n 
B 2 44  VAL 44  66  ?   ?   ?   B . n 
B 2 45  TRP 45  67  ?   ?   ?   B . n 
B 2 46  LYS 46  68  ?   ?   ?   B . n 
B 2 47  THR 47  69  ?   ?   ?   B . n 
B 2 48  ASN 48  70  ?   ?   ?   B . n 
B 2 49  HIS 49  71  ?   ?   ?   B . n 
B 2 50  PHE 50  72  ?   ?   ?   B . n 
B 2 51  THR 51  73  ?   ?   ?   B . n 
B 2 52  ILE 52  74  ?   ?   ?   B . n 
B 2 53  PRO 53  75  ?   ?   ?   B . n 
B 2 54  LYS 54  76  ?   ?   ?   B . n 
B 2 55  GLU 55  77  ?   ?   ?   B . n 
B 2 56  GLN 56  78  ?   ?   ?   B . n 
B 2 57  TYR 57  79  ?   ?   ?   B . n 
B 2 58  THR 58  80  ?   ?   ?   B . n 
B 2 59  ILE 59  81  ?   ?   ?   B . n 
B 2 60  ILE 60  82  ?   ?   ?   B . n 
B 2 61  ASN 61  83  ?   ?   ?   B . n 
B 2 62  ARG 62  84  ?   ?   ?   B . n 
B 2 63  THR 63  85  ?   ?   ?   B . n 
B 2 64  ALA 64  86  ?   ?   ?   B . n 
B 2 65  SER 65  87  ?   ?   ?   B . n 
B 2 66  SER 66  88  ?   ?   ?   B . n 
B 2 67  VAL 67  89  ?   ?   ?   B . n 
B 2 68  THR 68  90  ?   ?   ?   B . n 
B 2 69  PHE 69  91  ?   ?   ?   B . n 
B 2 70  THR 70  92  ?   ?   ?   B . n 
B 2 71  ASP 71  93  ?   ?   ?   B . n 
B 2 72  ILE 72  94  ?   ?   ?   B . n 
B 2 73  ALA 73  95  ?   ?   ?   B . n 
B 2 74  SER 74  96  ?   ?   ?   B . n 
B 2 75  LEU 75  97  ?   ?   ?   B . n 
B 2 76  ASN 76  98  ?   ?   ?   B . n 
B 2 77  ILE 77  99  ?   ?   ?   B . n 
B 2 78  GLN 78  100 ?   ?   ?   B . n 
B 2 79  LEU 79  101 ?   ?   ?   B . n 
B 2 80  THR 80  102 ?   ?   ?   B . n 
B 2 81  CYS 81  103 ?   ?   ?   B . n 
B 2 82  ASN 82  104 ?   ?   ?   B . n 
B 2 83  ILE 83  105 ?   ?   ?   B . n 
B 2 84  LEU 84  106 ?   ?   ?   B . n 
B 2 85  THR 85  107 ?   ?   ?   B . n 
B 2 86  PHE 86  108 ?   ?   ?   B . n 
B 2 87  GLY 87  109 ?   ?   ?   B . n 
B 2 88  GLN 88  110 ?   ?   ?   B . n 
B 2 89  LEU 89  111 ?   ?   ?   B . n 
B 2 90  GLU 90  112 ?   ?   ?   B . n 
B 2 91  GLN 91  113 ?   ?   ?   B . n 
B 2 92  ASN 92  114 ?   ?   ?   B . n 
B 2 93  VAL 93  115 ?   ?   ?   B . n 
B 2 94  TYR 94  116 ?   ?   ?   B . n 
B 2 95  GLY 95  117 ?   ?   ?   B . n 
B 2 96  ILE 96  118 ?   ?   ?   B . n 
B 2 97  THR 97  119 ?   ?   ?   B . n 
B 2 98  ILE 98  120 ?   ?   ?   B . n 
B 2 99  ILE 99  121 ?   ?   ?   B . n 
B 2 100 SER 100 122 ?   ?   ?   B . n 
B 2 101 GLY 101 123 ?   ?   ?   B . n 
B 2 102 LEU 102 124 ?   ?   ?   B . n 
B 2 103 PRO 103 125 125 PRO PRO B . n 
B 2 104 PRO 104 126 126 PRO PRO B . n 
B 2 105 GLU 105 127 127 GLU GLU B . n 
B 2 106 LYS 106 128 128 LYS LYS B . n 
B 2 107 PRO 107 129 129 PRO PRO B . n 
B 2 108 LYS 108 130 130 LYS LYS B . n 
B 2 109 ASN 109 131 131 ASN ASN B . n 
B 2 110 LEU 110 132 132 LEU LEU B . n 
B 2 111 SER 111 133 133 SER SER B . n 
B 2 112 CYS 112 134 134 CYS CYS B . n 
B 2 113 ILE 113 135 135 ILE ILE B . n 
B 2 114 VAL 114 136 136 VAL VAL B . n 
B 2 115 ASN 115 137 137 ASN ASN B . n 
B 2 116 GLU 116 138 138 GLU GLU B . n 
B 2 117 GLY 117 139 139 GLY GLY B . n 
B 2 118 LYS 118 140 140 LYS LYS B . n 
B 2 119 LYS 119 141 141 LYS LYS B . n 
B 2 120 MET 120 142 142 MET MET B . n 
B 2 121 ARG 121 143 143 ARG ARG B . n 
B 2 122 CYS 122 144 144 CYS CYS B . n 
B 2 123 GLU 123 145 145 GLU GLU B . n 
B 2 124 TRP 124 146 146 TRP TRP B . n 
B 2 125 ASP 125 147 147 ASP ASP B . n 
B 2 126 GLY 126 148 148 GLY GLY B . n 
B 2 127 GLY 127 149 149 GLY GLY B . n 
B 2 128 ARG 128 150 150 ARG ARG B . n 
B 2 129 GLU 129 151 151 GLU GLU B . n 
B 2 130 THR 130 152 152 THR THR B . n 
B 2 131 HIS 131 153 153 HIS HIS B . n 
B 2 132 LEU 132 154 154 LEU LEU B . n 
B 2 133 GLU 133 155 155 GLU GLU B . n 
B 2 134 THR 134 156 156 THR THR B . n 
B 2 135 ASN 135 157 157 ASN ASN B . n 
B 2 136 PHE 136 158 158 PHE PHE B . n 
B 2 137 THR 137 159 159 THR THR B . n 
B 2 138 LEU 138 160 160 LEU LEU B . n 
B 2 139 LYS 139 161 161 LYS LYS B . n 
B 2 140 SER 140 162 162 SER SER B . n 
B 2 141 GLU 141 163 163 GLU GLU B . n 
B 2 142 TRP 142 164 164 TRP TRP B . n 
B 2 143 ALA 143 165 165 ALA ALA B . n 
B 2 144 THR 144 166 166 THR THR B . n 
B 2 145 HIS 145 167 167 HIS HIS B . n 
B 2 146 LYS 146 168 168 LYS LYS B . n 
B 2 147 PHE 147 169 169 PHE PHE B . n 
B 2 148 ALA 148 170 170 ALA ALA B . n 
B 2 149 ASP 149 171 171 ASP ASP B . n 
B 2 150 CYS 150 172 172 CYS CYS B . n 
B 2 151 LYS 151 173 173 LYS LYS B . n 
B 2 152 ALA 152 174 174 ALA ALA B . n 
B 2 153 LYS 153 175 175 LYS LYS B . n 
B 2 154 ARG 154 176 176 ARG ARG B . n 
B 2 155 ASP 155 177 177 ASP ASP B . n 
B 2 156 THR 156 178 178 THR THR B . n 
B 2 157 PRO 157 179 179 PRO PRO B . n 
B 2 158 THR 158 180 180 THR THR B . n 
B 2 159 SER 159 181 181 SER SER B . n 
B 2 160 CYS 160 182 182 CYS CYS B . n 
B 2 161 THR 161 183 183 THR THR B . n 
B 2 162 VAL 162 184 184 VAL VAL B . n 
B 2 163 ASP 163 185 185 ASP ASP B . n 
B 2 164 TYR 164 186 186 TYR TYR B . n 
B 2 165 SER 165 187 187 SER SER B . n 
B 2 166 THR 166 188 188 THR THR B . n 
B 2 167 VAL 167 189 189 VAL VAL B . n 
B 2 168 TYR 168 190 190 TYR TYR B . n 
B 2 169 PHE 169 191 191 PHE PHE B . n 
B 2 170 VAL 170 192 192 VAL VAL B . n 
B 2 171 ASN 171 193 193 ASN ASN B . n 
B 2 172 ILE 172 194 194 ILE ILE B . n 
B 2 173 GLU 173 195 195 GLU GLU B . n 
B 2 174 VAL 174 196 196 VAL VAL B . n 
B 2 175 TRP 175 197 197 TRP TRP B . n 
B 2 176 VAL 176 198 198 VAL VAL B . n 
B 2 177 GLU 177 199 199 GLU GLU B . n 
B 2 178 ALA 178 200 200 ALA ALA B . n 
B 2 179 GLU 179 201 201 GLU GLU B . n 
B 2 180 ASN 180 202 202 ASN ASN B . n 
B 2 181 ALA 181 203 203 ALA ALA B . n 
B 2 182 LEU 182 204 204 LEU LEU B . n 
B 2 183 GLY 183 205 205 GLY GLY B . n 
B 2 184 LYS 184 206 206 LYS LYS B . n 
B 2 185 VAL 185 207 207 VAL VAL B . n 
B 2 186 THR 186 208 208 THR THR B . n 
B 2 187 SER 187 209 209 SER SER B . n 
B 2 188 ASP 188 210 210 ASP ASP B . n 
B 2 189 HIS 189 211 211 HIS HIS B . n 
B 2 190 ILE 190 212 212 ILE ILE B . n 
B 2 191 ASN 191 213 213 ASN ASN B . n 
B 2 192 PHE 192 214 214 PHE PHE B . n 
B 2 193 ASP 193 215 215 ASP ASP B . n 
B 2 194 PRO 194 216 216 PRO PRO B . n 
B 2 195 VAL 195 217 217 VAL VAL B . n 
B 2 196 TYR 196 218 218 TYR TYR B . n 
B 2 197 LYS 197 219 219 LYS LYS B . n 
B 2 198 VAL 198 220 220 VAL VAL B . n 
B 2 199 LYS 199 221 221 LYS LYS B . n 
B 2 200 PRO 200 222 222 PRO PRO B . n 
B 2 201 ASN 201 223 223 ASN ASN B . n 
B 2 202 PRO 202 224 224 PRO PRO B . n 
B 2 203 PRO 203 225 225 PRO PRO B . n 
B 2 204 HIS 204 226 226 HIS HIS B . n 
B 2 205 ASN 205 227 227 ASN ASN B . n 
B 2 206 LEU 206 228 228 LEU LEU B . n 
B 2 207 SER 207 229 229 SER SER B . n 
B 2 208 VAL 208 230 230 VAL VAL B . n 
B 2 209 ILE 209 231 231 ILE ILE B . n 
B 2 210 ASN 210 232 232 ASN ASN B . n 
B 2 211 SER 211 233 233 SER SER B . n 
B 2 212 GLU 212 234 234 GLU GLU B . n 
B 2 213 GLU 213 235 235 GLU GLU B . n 
B 2 214 LEU 214 236 236 LEU LEU B . n 
B 2 215 SER 215 237 237 SER SER B . n 
B 2 216 SER 216 238 238 SER SER B . n 
B 2 217 ILE 217 239 239 ILE ILE B . n 
B 2 218 LEU 218 240 240 LEU LEU B . n 
B 2 219 LYS 219 241 241 LYS LYS B . n 
B 2 220 LEU 220 242 242 LEU LEU B . n 
B 2 221 THR 221 243 243 THR THR B . n 
B 2 222 TRP 222 244 244 TRP TRP B . n 
B 2 223 THR 223 245 245 THR THR B . n 
B 2 224 ASN 224 246 246 ASN ASN B . n 
B 2 225 PRO 225 247 247 PRO PRO B . n 
B 2 226 SER 226 248 248 SER SER B . n 
B 2 227 ILE 227 249 249 ILE ILE B . n 
B 2 228 LYS 228 250 250 LYS LYS B . n 
B 2 229 SER 229 251 251 SER SER B . n 
B 2 230 VAL 230 252 252 VAL VAL B . n 
B 2 231 ILE 231 253 253 ILE ILE B . n 
B 2 232 ILE 232 254 254 ILE ILE B . n 
B 2 233 LEU 233 255 255 LEU LEU B . n 
B 2 234 LYS 234 256 256 LYS LYS B . n 
B 2 235 TYR 235 257 257 TYR TYR B . n 
B 2 236 ASN 236 258 258 ASN ASN B . n 
B 2 237 ILE 237 259 259 ILE ILE B . n 
B 2 238 GLN 238 260 260 GLN GLN B . n 
B 2 239 TYR 239 261 261 TYR TYR B . n 
B 2 240 ARG 240 262 262 ARG ARG B . n 
B 2 241 THR 241 263 263 THR THR B . n 
B 2 242 LYS 242 264 264 LYS LYS B . n 
B 2 243 ASP 243 265 265 ASP ASP B . n 
B 2 244 ALA 244 266 266 ALA ALA B . n 
B 2 245 SER 245 267 267 SER SER B . n 
B 2 246 THR 246 268 268 THR THR B . n 
B 2 247 TRP 247 269 269 TRP TRP B . n 
B 2 248 SER 248 270 270 SER SER B . n 
B 2 249 GLN 249 271 271 GLN GLN B . n 
B 2 250 ILE 250 272 272 ILE ILE B . n 
B 2 251 PRO 251 273 273 PRO PRO B . n 
B 2 252 PRO 252 274 274 PRO PRO B . n 
B 2 253 GLU 253 275 275 GLU GLU B . n 
B 2 254 ASP 254 276 276 ASP ASP B . n 
B 2 255 THR 255 277 277 THR THR B . n 
B 2 256 ALA 256 278 278 ALA ALA B . n 
B 2 257 SER 257 279 279 SER SER B . n 
B 2 258 THR 258 280 280 THR THR B . n 
B 2 259 ARG 259 281 281 ARG ARG B . n 
B 2 260 SER 260 282 282 SER SER B . n 
B 2 261 SER 261 283 283 SER SER B . n 
B 2 262 PHE 262 284 284 PHE PHE B . n 
B 2 263 THR 263 285 285 THR THR B . n 
B 2 264 VAL 264 286 286 VAL VAL B . n 
B 2 265 GLN 265 287 287 GLN GLN B . n 
B 2 266 ASP 266 288 288 ASP ASP B . n 
B 2 267 LEU 267 289 289 LEU LEU B . n 
B 2 268 LYS 268 290 290 LYS LYS B . n 
B 2 269 PRO 269 291 291 PRO PRO B . n 
B 2 270 PHE 270 292 292 PHE PHE B . n 
B 2 271 THR 271 293 293 THR THR B . n 
B 2 272 GLU 272 294 294 GLU GLU B . n 
B 2 273 TYR 273 295 295 TYR TYR B . n 
B 2 274 VAL 274 296 296 VAL VAL B . n 
B 2 275 PHE 275 297 297 PHE PHE B . n 
B 2 276 ARG 276 298 298 ARG ARG B . n 
B 2 277 ILE 277 299 299 ILE ILE B . n 
B 2 278 ARG 278 300 300 ARG ARG B . n 
B 2 279 CYS 279 301 301 CYS CYS B . n 
B 2 280 MET 280 302 302 MET MET B . n 
B 2 281 LYS 281 303 303 LYS LYS B . n 
B 2 282 GLU 282 304 304 GLU GLU B . n 
B 2 283 ASP 283 305 305 ASP ASP B . n 
B 2 284 GLY 284 306 306 GLY GLY B . n 
B 2 285 LYS 285 307 307 LYS LYS B . n 
B 2 286 GLY 286 308 308 GLY GLY B . n 
B 2 287 TYR 287 309 309 TYR TYR B . n 
B 2 288 TRP 288 310 310 TRP TRP B . n 
B 2 289 SER 289 311 311 SER SER B . n 
B 2 290 ASP 290 312 312 ASP ASP B . n 
B 2 291 TRP 291 313 313 TRP TRP B . n 
B 2 292 SER 292 314 314 SER SER B . n 
B 2 293 GLU 293 315 315 GLU GLU B . n 
B 2 294 GLU 294 316 316 GLU GLU B . n 
B 2 295 ALA 295 317 317 ALA ALA B . n 
B 2 296 SER 296 318 318 SER SER B . n 
B 2 297 GLY 297 319 319 GLY GLY B . n 
B 2 298 ILE 298 320 320 ILE ILE B . n 
B 2 299 THR 299 321 321 THR THR B . n 
B 2 300 TYR 300 322 322 TYR TYR B . n 
B 2 301 GLU 301 323 323 GLU GLU B . n 
B 2 302 ASP 302 324 ?   ?   ?   B . n 
B 2 303 ARG 303 325 ?   ?   ?   B . n 
B 2 304 PRO 304 326 ?   ?   ?   B . n 
B 2 305 SER 305 327 ?   ?   ?   B . n 
B 2 306 LYS 306 328 ?   ?   ?   B . n 
B 2 307 ALA 307 329 ?   ?   ?   B . n 
B 2 308 PRO 308 330 ?   ?   ?   B . n 
B 2 309 SER 309 331 ?   ?   ?   B . n 
B 2 310 PHE 310 332 ?   ?   ?   B . n 
B 2 311 TRP 311 333 ?   ?   ?   B . n 
B 2 312 TYR 312 334 ?   ?   ?   B . n 
B 2 313 LYS 313 335 ?   ?   ?   B . n 
B 2 314 ILE 314 336 ?   ?   ?   B . n 
B 2 315 ASP 315 337 ?   ?   ?   B . n 
B 2 316 PRO 316 338 ?   ?   ?   B . n 
B 2 317 SER 317 339 ?   ?   ?   B . n 
B 2 318 HIS 318 340 ?   ?   ?   B . n 
B 2 319 THR 319 341 ?   ?   ?   B . n 
B 2 320 GLN 320 342 ?   ?   ?   B . n 
B 2 321 GLY 321 343 ?   ?   ?   B . n 
B 2 322 TYR 322 344 ?   ?   ?   B . n 
B 2 323 ARG 323 345 ?   ?   ?   B . n 
B 2 324 THR 324 346 ?   ?   ?   B . n 
B 2 325 VAL 325 347 ?   ?   ?   B . n 
B 2 326 GLN 326 348 ?   ?   ?   B . n 
B 2 327 LEU 327 349 ?   ?   ?   B . n 
B 2 328 VAL 328 350 ?   ?   ?   B . n 
B 2 329 TRP 329 351 ?   ?   ?   B . n 
B 2 330 LYS 330 352 ?   ?   ?   B . n 
B 2 331 THR 331 353 ?   ?   ?   B . n 
B 2 332 LEU 332 354 ?   ?   ?   B . n 
B 2 333 PRO 333 355 ?   ?   ?   B . n 
B 2 334 PRO 334 356 ?   ?   ?   B . n 
B 2 335 PHE 335 357 ?   ?   ?   B . n 
B 2 336 GLU 336 358 ?   ?   ?   B . n 
B 2 337 ALA 337 359 ?   ?   ?   B . n 
B 2 338 ASN 338 360 ?   ?   ?   B . n 
B 2 339 GLY 339 361 ?   ?   ?   B . n 
B 2 340 LYS 340 362 ?   ?   ?   B . n 
B 2 341 ILE 341 363 ?   ?   ?   B . n 
B 2 342 LEU 342 364 ?   ?   ?   B . n 
B 2 343 ASP 343 365 ?   ?   ?   B . n 
B 2 344 TYR 344 366 ?   ?   ?   B . n 
B 2 345 GLU 345 367 ?   ?   ?   B . n 
B 2 346 VAL 346 368 ?   ?   ?   B . n 
B 2 347 THR 347 369 ?   ?   ?   B . n 
B 2 348 LEU 348 370 ?   ?   ?   B . n 
B 2 349 THR 349 371 ?   ?   ?   B . n 
B 2 350 ARG 350 372 ?   ?   ?   B . n 
B 2 351 TRP 351 373 ?   ?   ?   B . n 
B 2 352 LYS 352 374 ?   ?   ?   B . n 
B 2 353 SER 353 375 ?   ?   ?   B . n 
B 2 354 HIS 354 376 ?   ?   ?   B . n 
B 2 355 LEU 355 377 ?   ?   ?   B . n 
B 2 356 GLN 356 378 ?   ?   ?   B . n 
B 2 357 ASN 357 379 ?   ?   ?   B . n 
B 2 358 TYR 358 380 ?   ?   ?   B . n 
B 2 359 THR 359 381 ?   ?   ?   B . n 
B 2 360 VAL 360 382 ?   ?   ?   B . n 
B 2 361 ASN 361 383 ?   ?   ?   B . n 
B 2 362 ALA 362 384 ?   ?   ?   B . n 
B 2 363 THR 363 385 ?   ?   ?   B . n 
B 2 364 LYS 364 386 ?   ?   ?   B . n 
B 2 365 LEU 365 387 ?   ?   ?   B . n 
B 2 366 THR 366 388 ?   ?   ?   B . n 
B 2 367 VAL 367 389 ?   ?   ?   B . n 
B 2 368 ASN 368 390 ?   ?   ?   B . n 
B 2 369 LEU 369 391 ?   ?   ?   B . n 
B 2 370 THR 370 392 ?   ?   ?   B . n 
B 2 371 ASN 371 393 ?   ?   ?   B . n 
B 2 372 ASP 372 394 ?   ?   ?   B . n 
B 2 373 ARG 373 395 ?   ?   ?   B . n 
B 2 374 TYR 374 396 ?   ?   ?   B . n 
B 2 375 LEU 375 397 ?   ?   ?   B . n 
B 2 376 ALA 376 398 ?   ?   ?   B . n 
B 2 377 THR 377 399 ?   ?   ?   B . n 
B 2 378 LEU 378 400 ?   ?   ?   B . n 
B 2 379 THR 379 401 ?   ?   ?   B . n 
B 2 380 VAL 380 402 ?   ?   ?   B . n 
B 2 381 ARG 381 403 ?   ?   ?   B . n 
B 2 382 ASN 382 404 ?   ?   ?   B . n 
B 2 383 LEU 383 405 ?   ?   ?   B . n 
B 2 384 VAL 384 406 ?   ?   ?   B . n 
B 2 385 GLY 385 407 ?   ?   ?   B . n 
B 2 386 LYS 386 408 ?   ?   ?   B . n 
B 2 387 SER 387 409 ?   ?   ?   B . n 
B 2 388 ASP 388 410 ?   ?   ?   B . n 
B 2 389 ALA 389 411 ?   ?   ?   B . n 
B 2 390 ALA 390 412 ?   ?   ?   B . n 
B 2 391 VAL 391 413 ?   ?   ?   B . n 
B 2 392 LEU 392 414 ?   ?   ?   B . n 
B 2 393 THR 393 415 ?   ?   ?   B . n 
B 2 394 ILE 394 416 ?   ?   ?   B . n 
B 2 395 PRO 395 417 ?   ?   ?   B . n 
B 2 396 ALA 396 418 ?   ?   ?   B . n 
B 2 397 CYS 397 419 ?   ?   ?   B . n 
B 2 398 ASP 398 420 ?   ?   ?   B . n 
B 2 399 PHE 399 421 ?   ?   ?   B . n 
B 2 400 GLN 400 422 ?   ?   ?   B . n 
B 2 401 ALA 401 423 ?   ?   ?   B . n 
B 2 402 THR 402 424 ?   ?   ?   B . n 
B 2 403 HIS 403 425 ?   ?   ?   B . n 
B 2 404 PRO 404 426 ?   ?   ?   B . n 
B 2 405 VAL 405 427 ?   ?   ?   B . n 
B 2 406 MET 406 428 ?   ?   ?   B . n 
B 2 407 ASP 407 429 ?   ?   ?   B . n 
B 2 408 LEU 408 430 ?   ?   ?   B . n 
B 2 409 LYS 409 431 ?   ?   ?   B . n 
B 2 410 ALA 410 432 ?   ?   ?   B . n 
B 2 411 PHE 411 433 ?   ?   ?   B . n 
B 2 412 PRO 412 434 ?   ?   ?   B . n 
B 2 413 LYS 413 435 ?   ?   ?   B . n 
B 2 414 ASP 414 436 ?   ?   ?   B . n 
B 2 415 ASN 415 437 ?   ?   ?   B . n 
B 2 416 MET 416 438 ?   ?   ?   B . n 
B 2 417 LEU 417 439 ?   ?   ?   B . n 
B 2 418 TRP 418 440 ?   ?   ?   B . n 
B 2 419 VAL 419 441 ?   ?   ?   B . n 
B 2 420 GLU 420 442 ?   ?   ?   B . n 
B 2 421 TRP 421 443 ?   ?   ?   B . n 
B 2 422 THR 422 444 ?   ?   ?   B . n 
B 2 423 THR 423 445 ?   ?   ?   B . n 
B 2 424 PRO 424 446 ?   ?   ?   B . n 
B 2 425 ARG 425 447 ?   ?   ?   B . n 
B 2 426 GLU 426 448 ?   ?   ?   B . n 
B 2 427 SER 427 449 ?   ?   ?   B . n 
B 2 428 VAL 428 450 ?   ?   ?   B . n 
B 2 429 LYS 429 451 ?   ?   ?   B . n 
B 2 430 LYS 430 452 ?   ?   ?   B . n 
B 2 431 TYR 431 453 ?   ?   ?   B . n 
B 2 432 ILE 432 454 ?   ?   ?   B . n 
B 2 433 LEU 433 455 ?   ?   ?   B . n 
B 2 434 GLU 434 456 ?   ?   ?   B . n 
B 2 435 TRP 435 457 ?   ?   ?   B . n 
B 2 436 CYS 436 458 ?   ?   ?   B . n 
B 2 437 VAL 437 459 ?   ?   ?   B . n 
B 2 438 LEU 438 460 ?   ?   ?   B . n 
B 2 439 SER 439 461 ?   ?   ?   B . n 
B 2 440 ASP 440 462 ?   ?   ?   B . n 
B 2 441 LYS 441 463 ?   ?   ?   B . n 
B 2 442 ALA 442 464 ?   ?   ?   B . n 
B 2 443 PRO 443 465 ?   ?   ?   B . n 
B 2 444 CYS 444 466 ?   ?   ?   B . n 
B 2 445 ILE 445 467 ?   ?   ?   B . n 
B 2 446 THR 446 468 ?   ?   ?   B . n 
B 2 447 ASP 447 469 ?   ?   ?   B . n 
B 2 448 TRP 448 470 ?   ?   ?   B . n 
B 2 449 GLN 449 471 ?   ?   ?   B . n 
B 2 450 GLN 450 472 ?   ?   ?   B . n 
B 2 451 GLU 451 473 ?   ?   ?   B . n 
B 2 452 ASP 452 474 ?   ?   ?   B . n 
B 2 453 GLY 453 475 ?   ?   ?   B . n 
B 2 454 THR 454 476 ?   ?   ?   B . n 
B 2 455 VAL 455 477 ?   ?   ?   B . n 
B 2 456 HIS 456 478 ?   ?   ?   B . n 
B 2 457 ARG 457 479 ?   ?   ?   B . n 
B 2 458 THR 458 480 ?   ?   ?   B . n 
B 2 459 TYR 459 481 ?   ?   ?   B . n 
B 2 460 LEU 460 482 ?   ?   ?   B . n 
B 2 461 ARG 461 483 ?   ?   ?   B . n 
B 2 462 GLY 462 484 ?   ?   ?   B . n 
B 2 463 ASN 463 485 ?   ?   ?   B . n 
B 2 464 LEU 464 486 ?   ?   ?   B . n 
B 2 465 ALA 465 487 ?   ?   ?   B . n 
B 2 466 GLU 466 488 ?   ?   ?   B . n 
B 2 467 SER 467 489 ?   ?   ?   B . n 
B 2 468 LYS 468 490 ?   ?   ?   B . n 
B 2 469 CYS 469 491 ?   ?   ?   B . n 
B 2 470 TYR 470 492 ?   ?   ?   B . n 
B 2 471 LEU 471 493 ?   ?   ?   B . n 
B 2 472 ILE 472 494 ?   ?   ?   B . n 
B 2 473 THR 473 495 ?   ?   ?   B . n 
B 2 474 VAL 474 496 ?   ?   ?   B . n 
B 2 475 THR 475 497 ?   ?   ?   B . n 
B 2 476 PRO 476 498 ?   ?   ?   B . n 
B 2 477 VAL 477 499 ?   ?   ?   B . n 
B 2 478 TYR 478 500 ?   ?   ?   B . n 
B 2 479 ALA 479 501 ?   ?   ?   B . n 
B 2 480 ASP 480 502 ?   ?   ?   B . n 
B 2 481 GLY 481 503 ?   ?   ?   B . n 
B 2 482 PRO 482 504 ?   ?   ?   B . n 
B 2 483 GLY 483 505 ?   ?   ?   B . n 
B 2 484 SER 484 506 ?   ?   ?   B . n 
B 2 485 PRO 485 507 ?   ?   ?   B . n 
B 2 486 GLU 486 508 ?   ?   ?   B . n 
B 2 487 SER 487 509 ?   ?   ?   B . n 
B 2 488 ILE 488 510 ?   ?   ?   B . n 
B 2 489 LYS 489 511 ?   ?   ?   B . n 
B 2 490 ALA 490 512 ?   ?   ?   B . n 
B 2 491 TYR 491 513 ?   ?   ?   B . n 
B 2 492 LEU 492 514 ?   ?   ?   B . n 
B 2 493 LYS 493 515 ?   ?   ?   B . n 
B 2 494 GLN 494 516 ?   ?   ?   B . n 
B 2 495 ALA 495 517 ?   ?   ?   B . n 
B 2 496 PRO 496 518 ?   ?   ?   B . n 
B 2 497 PRO 497 519 ?   ?   ?   B . n 
B 2 498 SER 498 520 ?   ?   ?   B . n 
B 2 499 LYS 499 521 ?   ?   ?   B . n 
B 2 500 GLY 500 522 ?   ?   ?   B . n 
B 2 501 PRO 501 523 ?   ?   ?   B . n 
B 2 502 THR 502 524 ?   ?   ?   B . n 
B 2 503 VAL 503 525 ?   ?   ?   B . n 
B 2 504 ARG 504 526 ?   ?   ?   B . n 
B 2 505 THR 505 527 ?   ?   ?   B . n 
B 2 506 LYS 506 528 ?   ?   ?   B . n 
B 2 507 LYS 507 529 ?   ?   ?   B . n 
B 2 508 VAL 508 530 ?   ?   ?   B . n 
B 2 509 GLY 509 531 ?   ?   ?   B . n 
B 2 510 LYS 510 532 ?   ?   ?   B . n 
B 2 511 ASN 511 533 ?   ?   ?   B . n 
B 2 512 GLU 512 534 ?   ?   ?   B . n 
B 2 513 ALA 513 535 ?   ?   ?   B . n 
B 2 514 VAL 514 536 ?   ?   ?   B . n 
B 2 515 LEU 515 537 ?   ?   ?   B . n 
B 2 516 GLU 516 538 ?   ?   ?   B . n 
B 2 517 TRP 517 539 ?   ?   ?   B . n 
B 2 518 ASP 518 540 ?   ?   ?   B . n 
B 2 519 GLN 519 541 ?   ?   ?   B . n 
B 2 520 LEU 520 542 ?   ?   ?   B . n 
B 2 521 PRO 521 543 ?   ?   ?   B . n 
B 2 522 VAL 522 544 ?   ?   ?   B . n 
B 2 523 ASP 523 545 ?   ?   ?   B . n 
B 2 524 VAL 524 546 ?   ?   ?   B . n 
B 2 525 GLN 525 547 ?   ?   ?   B . n 
B 2 526 ASN 526 548 ?   ?   ?   B . n 
B 2 527 GLY 527 549 ?   ?   ?   B . n 
B 2 528 PHE 528 550 ?   ?   ?   B . n 
B 2 529 ILE 529 551 ?   ?   ?   B . n 
B 2 530 ARG 530 552 ?   ?   ?   B . n 
B 2 531 ASN 531 553 ?   ?   ?   B . n 
B 2 532 TYR 532 554 ?   ?   ?   B . n 
B 2 533 THR 533 555 ?   ?   ?   B . n 
B 2 534 ILE 534 556 ?   ?   ?   B . n 
B 2 535 PHE 535 557 ?   ?   ?   B . n 
B 2 536 TYR 536 558 ?   ?   ?   B . n 
B 2 537 ARG 537 559 ?   ?   ?   B . n 
B 2 538 THR 538 560 ?   ?   ?   B . n 
B 2 539 ILE 539 561 ?   ?   ?   B . n 
B 2 540 ILE 540 562 ?   ?   ?   B . n 
B 2 541 GLY 541 563 ?   ?   ?   B . n 
B 2 542 ASN 542 564 ?   ?   ?   B . n 
B 2 543 GLU 543 565 ?   ?   ?   B . n 
B 2 544 THR 544 566 ?   ?   ?   B . n 
B 2 545 ALA 545 567 ?   ?   ?   B . n 
B 2 546 VAL 546 568 ?   ?   ?   B . n 
B 2 547 ASN 547 569 ?   ?   ?   B . n 
B 2 548 VAL 548 570 ?   ?   ?   B . n 
B 2 549 ASP 549 571 ?   ?   ?   B . n 
B 2 550 SER 550 572 ?   ?   ?   B . n 
B 2 551 SER 551 573 ?   ?   ?   B . n 
B 2 552 HIS 552 574 ?   ?   ?   B . n 
B 2 553 THR 553 575 ?   ?   ?   B . n 
B 2 554 GLU 554 576 ?   ?   ?   B . n 
B 2 555 TYR 555 577 ?   ?   ?   B . n 
B 2 556 THR 556 578 ?   ?   ?   B . n 
B 2 557 LEU 557 579 ?   ?   ?   B . n 
B 2 558 SER 558 580 ?   ?   ?   B . n 
B 2 559 SER 559 581 ?   ?   ?   B . n 
B 2 560 LEU 560 582 ?   ?   ?   B . n 
B 2 561 THR 561 583 ?   ?   ?   B . n 
B 2 562 SER 562 584 ?   ?   ?   B . n 
B 2 563 ASP 563 585 ?   ?   ?   B . n 
B 2 564 THR 564 586 ?   ?   ?   B . n 
B 2 565 LEU 565 587 ?   ?   ?   B . n 
B 2 566 TYR 566 588 ?   ?   ?   B . n 
B 2 567 MET 567 589 ?   ?   ?   B . n 
B 2 568 VAL 568 590 ?   ?   ?   B . n 
B 2 569 ARG 569 591 ?   ?   ?   B . n 
B 2 570 MET 570 592 ?   ?   ?   B . n 
B 2 571 ALA 571 593 ?   ?   ?   B . n 
B 2 572 ALA 572 594 ?   ?   ?   B . n 
B 2 573 TYR 573 595 ?   ?   ?   B . n 
B 2 574 THR 574 596 ?   ?   ?   B . n 
B 2 575 ASP 575 597 ?   ?   ?   B . n 
B 2 576 GLU 576 598 ?   ?   ?   B . n 
B 2 577 GLY 577 599 ?   ?   ?   B . n 
B 2 578 GLY 578 600 ?   ?   ?   B . n 
B 2 579 LYS 579 601 ?   ?   ?   B . n 
B 2 580 ASP 580 602 ?   ?   ?   B . n 
B 2 581 GLY 581 603 ?   ?   ?   B . n 
B 2 582 PRO 582 604 ?   ?   ?   B . n 
B 2 583 GLU 583 605 ?   ?   ?   B . n 
B 2 584 PHE 584 606 ?   ?   ?   B . n 
B 2 585 THR 585 607 ?   ?   ?   B . n 
B 2 586 PHE 586 608 ?   ?   ?   B . n 
B 2 587 THR 587 609 ?   ?   ?   B . n 
B 2 588 THR 588 610 ?   ?   ?   B . n 
B 2 589 PRO 589 611 ?   ?   ?   B . n 
B 2 590 LYS 590 612 ?   ?   ?   B . n 
B 2 591 PHE 591 613 ?   ?   ?   B . n 
B 2 592 ALA 592 614 ?   ?   ?   B . n 
B 2 593 GLN 593 615 ?   ?   ?   B . n 
B 2 594 GLY 594 616 ?   ?   ?   B . n 
B 2 595 GLU 595 617 ?   ?   ?   B . n 
B 2 596 ILE 596 618 ?   ?   ?   B . n 
B 2 597 GLU 597 619 ?   ?   ?   B . n 
B 2 598 GLU 598 620 ?   ?   ?   B . n 
B 2 599 GLN 599 621 ?   ?   ?   B . n 
B 2 600 LYS 600 622 ?   ?   ?   B . n 
B 2 601 LEU 601 623 ?   ?   ?   B . n 
B 2 602 ILE 602 624 ?   ?   ?   B . n 
B 2 603 SER 603 625 ?   ?   ?   B . n 
B 2 604 GLU 604 626 ?   ?   ?   B . n 
B 2 605 GLU 605 627 ?   ?   ?   B . n 
B 2 606 ASP 606 628 ?   ?   ?   B . n 
B 2 607 LEU 607 629 ?   ?   ?   B . n 
B 2 608 GLY 608 630 ?   ?   ?   B . n 
B 2 609 GLY 609 631 ?   ?   ?   B . n 
B 2 610 GLU 610 632 ?   ?   ?   B . n 
B 2 611 GLN 611 633 ?   ?   ?   B . n 
B 2 612 LYS 612 634 ?   ?   ?   B . n 
B 2 613 LEU 613 635 ?   ?   ?   B . n 
B 2 614 ILE 614 636 ?   ?   ?   B . n 
B 2 615 SER 615 637 ?   ?   ?   B . n 
B 2 616 GLU 616 638 ?   ?   ?   B . n 
B 2 617 GLU 617 639 ?   ?   ?   B . n 
B 2 618 ASP 618 640 ?   ?   ?   B . n 
B 2 619 LEU 619 641 ?   ?   ?   B . n 
B 2 620 HIS 620 642 ?   ?   ?   B . n 
B 2 621 HIS 621 643 ?   ?   ?   B . n 
B 2 622 HIS 622 644 ?   ?   ?   B . n 
B 2 623 HIS 623 645 ?   ?   ?   B . n 
B 2 624 HIS 624 646 ?   ?   ?   B . n 
B 2 625 HIS 625 647 ?   ?   ?   B . n 
C 3 1   GLN 1   45  ?   ?   ?   C . n 
C 3 2   LYS 2   46  ?   ?   ?   C . n 
C 3 3   LYS 3   47  ?   ?   ?   C . n 
C 3 4   GLY 4   48  ?   ?   ?   C . n 
C 3 5   ALA 5   49  ?   ?   ?   C . n 
C 3 6   PRO 6   50  ?   ?   ?   C . n 
C 3 7   HIS 7   51  ?   ?   ?   C . n 
C 3 8   ASP 8   52  ?   ?   ?   C . n 
C 3 9   LEU 9   53  ?   ?   ?   C . n 
C 3 10  LYS 10  54  ?   ?   ?   C . n 
C 3 11  CYS 11  55  ?   ?   ?   C . n 
C 3 12  VAL 12  56  ?   ?   ?   C . n 
C 3 13  THR 13  57  ?   ?   ?   C . n 
C 3 14  ASN 14  58  ?   ?   ?   C . n 
C 3 15  ASN 15  59  ?   ?   ?   C . n 
C 3 16  LEU 16  60  ?   ?   ?   C . n 
C 3 17  GLN 17  61  ?   ?   ?   C . n 
C 3 18  VAL 18  62  ?   ?   ?   C . n 
C 3 19  TRP 19  63  ?   ?   ?   C . n 
C 3 20  ASN 20  64  ?   ?   ?   C . n 
C 3 21  CYS 21  65  ?   ?   ?   C . n 
C 3 22  SER 22  66  ?   ?   ?   C . n 
C 3 23  TRP 23  67  ?   ?   ?   C . n 
C 3 24  LYS 24  68  ?   ?   ?   C . n 
C 3 25  ALA 25  69  ?   ?   ?   C . n 
C 3 26  PRO 26  70  ?   ?   ?   C . n 
C 3 27  SER 27  71  ?   ?   ?   C . n 
C 3 28  GLY 28  72  ?   ?   ?   C . n 
C 3 29  THR 29  73  ?   ?   ?   C . n 
C 3 30  GLY 30  74  ?   ?   ?   C . n 
C 3 31  ARG 31  75  ?   ?   ?   C . n 
C 3 32  GLY 32  76  ?   ?   ?   C . n 
C 3 33  THR 33  77  ?   ?   ?   C . n 
C 3 34  ASP 34  78  ?   ?   ?   C . n 
C 3 35  TYR 35  79  ?   ?   ?   C . n 
C 3 36  GLU 36  80  ?   ?   ?   C . n 
C 3 37  VAL 37  81  ?   ?   ?   C . n 
C 3 38  CYS 38  82  ?   ?   ?   C . n 
C 3 39  ILE 39  83  ?   ?   ?   C . n 
C 3 40  GLU 40  84  ?   ?   ?   C . n 
C 3 41  ASN 41  85  ?   ?   ?   C . n 
C 3 42  ARG 42  86  ?   ?   ?   C . n 
C 3 43  SER 43  87  ?   ?   ?   C . n 
C 3 44  ARG 44  88  ?   ?   ?   C . n 
C 3 45  SER 45  89  ?   ?   ?   C . n 
C 3 46  CYS 46  90  ?   ?   ?   C . n 
C 3 47  TYR 47  91  ?   ?   ?   C . n 
C 3 48  GLN 48  92  ?   ?   ?   C . n 
C 3 49  LEU 49  93  ?   ?   ?   C . n 
C 3 50  GLU 50  94  ?   ?   ?   C . n 
C 3 51  LYS 51  95  ?   ?   ?   C . n 
C 3 52  THR 52  96  ?   ?   ?   C . n 
C 3 53  SER 53  97  ?   ?   ?   C . n 
C 3 54  ILE 54  98  ?   ?   ?   C . n 
C 3 55  LYS 55  99  ?   ?   ?   C . n 
C 3 56  ILE 56  100 ?   ?   ?   C . n 
C 3 57  PRO 57  101 ?   ?   ?   C . n 
C 3 58  ALA 58  102 ?   ?   ?   C . n 
C 3 59  LEU 59  103 ?   ?   ?   C . n 
C 3 60  SER 60  104 ?   ?   ?   C . n 
C 3 61  HIS 61  105 ?   ?   ?   C . n 
C 3 62  GLY 62  106 ?   ?   ?   C . n 
C 3 63  ASP 63  107 ?   ?   ?   C . n 
C 3 64  TYR 64  108 ?   ?   ?   C . n 
C 3 65  GLU 65  109 ?   ?   ?   C . n 
C 3 66  ILE 66  110 ?   ?   ?   C . n 
C 3 67  THR 67  111 ?   ?   ?   C . n 
C 3 68  ILE 68  112 ?   ?   ?   C . n 
C 3 69  ASN 69  113 ?   ?   ?   C . n 
C 3 70  SER 70  114 ?   ?   ?   C . n 
C 3 71  LEU 71  115 ?   ?   ?   C . n 
C 3 72  HIS 72  116 ?   ?   ?   C . n 
C 3 73  ASP 73  117 ?   ?   ?   C . n 
C 3 74  PHE 74  118 ?   ?   ?   C . n 
C 3 75  GLY 75  119 ?   ?   ?   C . n 
C 3 76  SER 76  120 ?   ?   ?   C . n 
C 3 77  SER 77  121 ?   ?   ?   C . n 
C 3 78  THR 78  122 ?   ?   ?   C . n 
C 3 79  SER 79  123 ?   ?   ?   C . n 
C 3 80  LYS 80  124 ?   ?   ?   C . n 
C 3 81  PHE 81  125 ?   ?   ?   C . n 
C 3 82  THR 82  126 ?   ?   ?   C . n 
C 3 83  LEU 83  127 ?   ?   ?   C . n 
C 3 84  ASN 84  128 ?   ?   ?   C . n 
C 3 85  GLU 85  129 ?   ?   ?   C . n 
C 3 86  GLN 86  130 ?   ?   ?   C . n 
C 3 87  ASN 87  131 ?   ?   ?   C . n 
C 3 88  VAL 88  132 ?   ?   ?   C . n 
C 3 89  SER 89  133 ?   ?   ?   C . n 
C 3 90  LEU 90  134 ?   ?   ?   C . n 
C 3 91  ILE 91  135 ?   ?   ?   C . n 
C 3 92  PRO 92  136 ?   ?   ?   C . n 
C 3 93  ASP 93  137 ?   ?   ?   C . n 
C 3 94  THR 94  138 ?   ?   ?   C . n 
C 3 95  PRO 95  139 ?   ?   ?   C . n 
C 3 96  GLU 96  140 ?   ?   ?   C . n 
C 3 97  ILE 97  141 ?   ?   ?   C . n 
C 3 98  LEU 98  142 ?   ?   ?   C . n 
C 3 99  ASN 99  143 ?   ?   ?   C . n 
C 3 100 LEU 100 144 ?   ?   ?   C . n 
C 3 101 SER 101 145 ?   ?   ?   C . n 
C 3 102 ALA 102 146 ?   ?   ?   C . n 
C 3 103 ASP 103 147 ?   ?   ?   C . n 
C 3 104 PHE 104 148 ?   ?   ?   C . n 
C 3 105 SER 105 149 ?   ?   ?   C . n 
C 3 106 THR 106 150 ?   ?   ?   C . n 
C 3 107 SER 107 151 ?   ?   ?   C . n 
C 3 108 THR 108 152 ?   ?   ?   C . n 
C 3 109 LEU 109 153 ?   ?   ?   C . n 
C 3 110 TYR 110 154 ?   ?   ?   C . n 
C 3 111 LEU 111 155 ?   ?   ?   C . n 
C 3 112 LYS 112 156 ?   ?   ?   C . n 
C 3 113 TRP 113 157 ?   ?   ?   C . n 
C 3 114 ASN 114 158 ?   ?   ?   C . n 
C 3 115 ASP 115 159 ?   ?   ?   C . n 
C 3 116 ARG 116 160 ?   ?   ?   C . n 
C 3 117 GLY 117 161 ?   ?   ?   C . n 
C 3 118 SER 118 162 ?   ?   ?   C . n 
C 3 119 VAL 119 163 ?   ?   ?   C . n 
C 3 120 PHE 120 164 ?   ?   ?   C . n 
C 3 121 PRO 121 165 ?   ?   ?   C . n 
C 3 122 HIS 122 166 ?   ?   ?   C . n 
C 3 123 ARG 123 167 ?   ?   ?   C . n 
C 3 124 SER 124 168 ?   ?   ?   C . n 
C 3 125 ASN 125 169 ?   ?   ?   C . n 
C 3 126 VAL 126 170 ?   ?   ?   C . n 
C 3 127 ILE 127 171 ?   ?   ?   C . n 
C 3 128 TRP 128 172 ?   ?   ?   C . n 
C 3 129 GLU 129 173 ?   ?   ?   C . n 
C 3 130 ILE 130 174 ?   ?   ?   C . n 
C 3 131 LYS 131 175 ?   ?   ?   C . n 
C 3 132 VAL 132 176 ?   ?   ?   C . n 
C 3 133 LEU 133 177 ?   ?   ?   C . n 
C 3 134 ARG 134 178 ?   ?   ?   C . n 
C 3 135 LYS 135 179 ?   ?   ?   C . n 
C 3 136 GLU 136 180 ?   ?   ?   C . n 
C 3 137 SER 137 181 ?   ?   ?   C . n 
C 3 138 MET 138 182 ?   ?   ?   C . n 
C 3 139 GLU 139 183 ?   ?   ?   C . n 
C 3 140 LEU 140 184 ?   ?   ?   C . n 
C 3 141 VAL 141 185 ?   ?   ?   C . n 
C 3 142 LYS 142 186 ?   ?   ?   C . n 
C 3 143 LEU 143 187 ?   ?   ?   C . n 
C 3 144 VAL 144 188 ?   ?   ?   C . n 
C 3 145 THR 145 189 ?   ?   ?   C . n 
C 3 146 HIS 146 190 ?   ?   ?   C . n 
C 3 147 ASN 147 191 ?   ?   ?   C . n 
C 3 148 THR 148 192 ?   ?   ?   C . n 
C 3 149 THR 149 193 ?   ?   ?   C . n 
C 3 150 LEU 150 194 ?   ?   ?   C . n 
C 3 151 ASN 151 195 ?   ?   ?   C . n 
C 3 152 GLY 152 196 ?   ?   ?   C . n 
C 3 153 LYS 153 197 ?   ?   ?   C . n 
C 3 154 ASP 154 198 ?   ?   ?   C . n 
C 3 155 THR 155 199 ?   ?   ?   C . n 
C 3 156 LEU 156 200 ?   ?   ?   C . n 
C 3 157 HIS 157 201 ?   ?   ?   C . n 
C 3 158 HIS 158 202 ?   ?   ?   C . n 
C 3 159 TRP 159 203 ?   ?   ?   C . n 
C 3 160 SER 160 204 ?   ?   ?   C . n 
C 3 161 TRP 161 205 ?   ?   ?   C . n 
C 3 162 ALA 162 206 ?   ?   ?   C . n 
C 3 163 SER 163 207 ?   ?   ?   C . n 
C 3 164 ASP 164 208 ?   ?   ?   C . n 
C 3 165 MET 165 209 ?   ?   ?   C . n 
C 3 166 PRO 166 210 ?   ?   ?   C . n 
C 3 167 LEU 167 211 ?   ?   ?   C . n 
C 3 168 GLU 168 212 ?   ?   ?   C . n 
C 3 169 CYS 169 213 ?   ?   ?   C . n 
C 3 170 ALA 170 214 ?   ?   ?   C . n 
C 3 171 ILE 171 215 ?   ?   ?   C . n 
C 3 172 HIS 172 216 ?   ?   ?   C . n 
C 3 173 PHE 173 217 ?   ?   ?   C . n 
C 3 174 VAL 174 218 ?   ?   ?   C . n 
C 3 175 GLU 175 219 ?   ?   ?   C . n 
C 3 176 ILE 176 220 ?   ?   ?   C . n 
C 3 177 ARG 177 221 ?   ?   ?   C . n 
C 3 178 CYS 178 222 ?   ?   ?   C . n 
C 3 179 TYR 179 223 ?   ?   ?   C . n 
C 3 180 ILE 180 224 ?   ?   ?   C . n 
C 3 181 ASP 181 225 ?   ?   ?   C . n 
C 3 182 ASN 182 226 ?   ?   ?   C . n 
C 3 183 LEU 183 227 ?   ?   ?   C . n 
C 3 184 HIS 184 228 ?   ?   ?   C . n 
C 3 185 PHE 185 229 ?   ?   ?   C . n 
C 3 186 SER 186 230 ?   ?   ?   C . n 
C 3 187 GLY 187 231 ?   ?   ?   C . n 
C 3 188 LEU 188 232 ?   ?   ?   C . n 
C 3 189 GLU 189 233 ?   ?   ?   C . n 
C 3 190 GLU 190 234 ?   ?   ?   C . n 
C 3 191 TRP 191 235 ?   ?   ?   C . n 
C 3 192 SER 192 236 ?   ?   ?   C . n 
C 3 193 ASP 193 237 ?   ?   ?   C . n 
C 3 194 TRP 194 238 ?   ?   ?   C . n 
C 3 195 SER 195 239 ?   ?   ?   C . n 
C 3 196 PRO 196 240 ?   ?   ?   C . n 
C 3 197 VAL 197 241 ?   ?   ?   C . n 
C 3 198 LYS 198 242 ?   ?   ?   C . n 
C 3 199 ASN 199 243 ?   ?   ?   C . n 
C 3 200 ILE 200 244 ?   ?   ?   C . n 
C 3 201 SER 201 245 ?   ?   ?   C . n 
C 3 202 TRP 202 246 ?   ?   ?   C . n 
C 3 203 ILE 203 247 ?   ?   ?   C . n 
C 3 204 PRO 204 248 ?   ?   ?   C . n 
C 3 205 ASP 205 249 ?   ?   ?   C . n 
C 3 206 SER 206 250 ?   ?   ?   C . n 
C 3 207 GLN 207 251 ?   ?   ?   C . n 
C 3 208 THR 208 252 252 THR THR C . n 
C 3 209 LYS 209 253 253 LYS LYS C . n 
C 3 210 VAL 210 254 254 VAL VAL C . n 
C 3 211 PHE 211 255 255 PHE PHE C . n 
C 3 212 PRO 212 256 256 PRO PRO C . n 
C 3 213 GLN 213 257 257 GLN GLN C . n 
C 3 214 ASP 214 258 258 ASP ASP C . n 
C 3 215 LYS 215 259 259 LYS LYS C . n 
C 3 216 VAL 216 260 260 VAL VAL C . n 
C 3 217 ILE 217 261 261 ILE ILE C . n 
C 3 218 LEU 218 262 262 LEU LEU C . n 
C 3 219 VAL 219 263 263 VAL VAL C . n 
C 3 220 GLY 220 264 264 GLY GLY C . n 
C 3 221 SER 221 265 265 SER SER C . n 
C 3 222 ASP 222 266 266 ASP ASP C . n 
C 3 223 ILE 223 267 267 ILE ILE C . n 
C 3 224 THR 224 268 268 THR THR C . n 
C 3 225 PHE 225 269 269 PHE PHE C . n 
C 3 226 CYS 226 270 270 CYS CYS C . n 
C 3 227 CYS 227 271 271 CYS CYS C . n 
C 3 228 VAL 228 272 272 VAL VAL C . n 
C 3 229 SER 229 273 273 SER SER C . n 
C 3 230 GLN 230 274 274 GLN GLN C . n 
C 3 231 GLU 231 275 275 GLU GLU C . n 
C 3 232 LYS 232 276 276 LYS LYS C . n 
C 3 233 VAL 233 277 277 VAL VAL C . n 
C 3 234 LEU 234 278 278 LEU LEU C . n 
C 3 235 SER 235 279 279 SER SER C . n 
C 3 236 ALA 236 280 280 ALA ALA C . n 
C 3 237 LEU 237 281 281 LEU LEU C . n 
C 3 238 ILE 238 282 282 ILE ILE C . n 
C 3 239 GLY 239 283 283 GLY GLY C . n 
C 3 240 HIS 240 284 284 HIS HIS C . n 
C 3 241 THR 241 285 285 THR THR C . n 
C 3 242 ASN 242 286 286 ASN ASN C . n 
C 3 243 CYS 243 287 287 CYS CYS C . n 
C 3 244 PRO 244 288 288 PRO PRO C . n 
C 3 245 LEU 245 289 289 LEU LEU C . n 
C 3 246 ILE 246 290 290 ILE ILE C . n 
C 3 247 HIS 247 291 291 HIS HIS C . n 
C 3 248 LEU 248 292 292 LEU LEU C . n 
C 3 249 ASP 249 293 293 ASP ASP C . n 
C 3 250 GLY 250 294 294 GLY GLY C . n 
C 3 251 GLU 251 295 295 GLU GLU C . n 
C 3 252 ASN 252 296 296 ASN ASN C . n 
C 3 253 VAL 253 297 297 VAL VAL C . n 
C 3 254 ALA 254 298 298 ALA ALA C . n 
C 3 255 ILE 255 299 299 ILE ILE C . n 
C 3 256 LYS 256 300 300 LYS LYS C . n 
C 3 257 ILE 257 301 301 ILE ILE C . n 
C 3 258 ARG 258 302 302 ARG ARG C . n 
C 3 259 ASN 259 303 303 ASN ASN C . n 
C 3 260 ILE 260 304 304 ILE ILE C . n 
C 3 261 SER 261 305 305 SER SER C . n 
C 3 262 VAL 262 306 306 VAL VAL C . n 
C 3 263 SER 263 307 307 SER SER C . n 
C 3 264 ALA 264 308 308 ALA ALA C . n 
C 3 265 SER 265 309 309 SER SER C . n 
C 3 266 SER 266 310 310 SER SER C . n 
C 3 267 GLY 267 311 311 GLY GLY C . n 
C 3 268 THR 268 312 312 THR THR C . n 
C 3 269 ASN 269 313 313 ASN ASN C . n 
C 3 270 VAL 270 314 314 VAL VAL C . n 
C 3 271 VAL 271 315 315 VAL VAL C . n 
C 3 272 PHE 272 316 316 PHE PHE C . n 
C 3 273 THR 273 317 317 THR THR C . n 
C 3 274 THR 274 318 318 THR THR C . n 
C 3 275 GLU 275 319 319 GLU GLU C . n 
C 3 276 ASP 276 320 320 ASP ASP C . n 
C 3 277 ASN 277 321 321 ASN ASN C . n 
C 3 278 ILE 278 322 322 ILE ILE C . n 
C 3 279 PHE 279 323 323 PHE PHE C . n 
C 3 280 GLY 280 324 324 GLY GLY C . n 
C 3 281 THR 281 325 325 THR THR C . n 
C 3 282 VAL 282 326 326 VAL VAL C . n 
C 3 283 ILE 283 327 327 ILE ILE C . n 
C 3 284 PHE 284 328 328 PHE PHE C . n 
C 3 285 ALA 285 329 329 ALA ALA C . n 
C 3 286 GLY 286 330 330 GLY GLY C . n 
C 3 287 TYR 287 331 331 TYR TYR C . n 
C 3 288 PRO 288 332 332 PRO PRO C . n 
C 3 289 PRO 289 333 333 PRO PRO C . n 
C 3 290 ASP 290 334 334 ASP ASP C . n 
C 3 291 THR 291 335 335 THR THR C . n 
C 3 292 PRO 292 336 336 PRO PRO C . n 
C 3 293 GLN 293 337 337 GLN GLN C . n 
C 3 294 GLN 294 338 338 GLN GLN C . n 
C 3 295 LEU 295 339 339 LEU LEU C . n 
C 3 296 ASN 296 340 340 ASN ASN C . n 
C 3 297 CYS 297 341 341 CYS CYS C . n 
C 3 298 GLU 298 342 342 GLU GLU C . n 
C 3 299 THR 299 343 343 THR THR C . n 
C 3 300 HIS 300 344 344 HIS HIS C . n 
C 3 301 ASP 301 345 345 ASP ASP C . n 
C 3 302 LEU 302 346 346 LEU LEU C . n 
C 3 303 LYS 303 347 347 LYS LYS C . n 
C 3 304 GLU 304 348 348 GLU GLU C . n 
C 3 305 ILE 305 349 349 ILE ILE C . n 
C 3 306 ILE 306 350 350 ILE ILE C . n 
C 3 307 CYS 307 351 351 CYS CYS C . n 
C 3 308 SER 308 352 352 SER SER C . n 
C 3 309 TRP 309 353 353 TRP TRP C . n 
C 3 310 ASN 310 354 354 ASN ASN C . n 
C 3 311 PRO 311 355 355 PRO PRO C . n 
C 3 312 GLY 312 356 356 GLY GLY C . n 
C 3 313 ARG 313 357 357 ARG ARG C . n 
C 3 314 VAL 314 358 358 VAL VAL C . n 
C 3 315 THR 315 359 359 THR THR C . n 
C 3 316 ALA 316 360 360 ALA ALA C . n 
C 3 317 LEU 317 361 361 LEU LEU C . n 
C 3 318 VAL 318 362 362 VAL VAL C . n 
C 3 319 GLY 319 363 363 GLY GLY C . n 
C 3 320 PRO 320 364 364 PRO PRO C . n 
C 3 321 ARG 321 365 365 ARG ARG C . n 
C 3 322 ALA 322 366 366 ALA ALA C . n 
C 3 323 THR 323 367 367 THR THR C . n 
C 3 324 SER 324 368 368 SER SER C . n 
C 3 325 TYR 325 369 369 TYR TYR C . n 
C 3 326 THR 326 370 370 THR THR C . n 
C 3 327 LEU 327 371 371 LEU LEU C . n 
C 3 328 VAL 328 372 372 VAL VAL C . n 
C 3 329 GLU 329 373 373 GLU GLU C . n 
C 3 330 SER 330 374 374 SER SER C . n 
C 3 331 PHE 331 375 375 PHE PHE C . n 
C 3 332 SER 332 376 376 SER SER C . n 
C 3 333 GLY 333 377 377 GLY GLY C . n 
C 3 334 LYS 334 378 378 LYS LYS C . n 
C 3 335 TYR 335 379 379 TYR TYR C . n 
C 3 336 VAL 336 380 380 VAL VAL C . n 
C 3 337 ARG 337 381 381 ARG ARG C . n 
C 3 338 LEU 338 382 382 LEU LEU C . n 
C 3 339 LYS 339 383 383 LYS LYS C . n 
C 3 340 ARG 340 384 384 ARG ARG C . n 
C 3 341 ALA 341 385 385 ALA ALA C . n 
C 3 342 GLU 342 386 386 GLU GLU C . n 
C 3 343 ALA 343 387 387 ALA ALA C . n 
C 3 344 PRO 344 388 388 PRO PRO C . n 
C 3 345 THR 345 389 389 THR THR C . n 
C 3 346 ASN 346 390 390 ASN ASN C . n 
C 3 347 GLU 347 391 391 GLU GLU C . n 
C 3 348 SER 348 392 392 SER SER C . n 
C 3 349 TYR 349 393 393 TYR TYR C . n 
C 3 350 GLN 350 394 394 GLN GLN C . n 
C 3 351 LEU 351 395 395 LEU LEU C . n 
C 3 352 LEU 352 396 396 LEU LEU C . n 
C 3 353 PHE 353 397 397 PHE PHE C . n 
C 3 354 GLN 354 398 398 GLN GLN C . n 
C 3 355 MET 355 399 399 MET MET C . n 
C 3 356 LEU 356 400 400 LEU LEU C . n 
C 3 357 PRO 357 401 401 PRO PRO C . n 
C 3 358 ASN 358 402 402 ASN ASN C . n 
C 3 359 GLN 359 403 403 GLN GLN C . n 
C 3 360 GLU 360 404 404 GLU GLU C . n 
C 3 361 ILE 361 405 405 ILE ILE C . n 
C 3 362 TYR 362 406 406 TYR TYR C . n 
C 3 363 ASN 363 407 407 ASN ASN C . n 
C 3 364 PHE 364 408 408 PHE PHE C . n 
C 3 365 THR 365 409 409 THR THR C . n 
C 3 366 LEU 366 410 410 LEU LEU C . n 
C 3 367 ASN 367 411 411 ASN ASN C . n 
C 3 368 ALA 368 412 412 ALA ALA C . n 
C 3 369 HIS 369 413 413 HIS HIS C . n 
C 3 370 ASN 370 414 414 ASN ASN C . n 
C 3 371 PRO 371 415 415 PRO PRO C . n 
C 3 372 LEU 372 416 416 LEU LEU C . n 
C 3 373 GLY 373 417 417 GLY GLY C . n 
C 3 374 ARG 374 418 418 ARG ARG C . n 
C 3 375 SER 375 419 419 SER SER C . n 
C 3 376 GLN 376 420 420 GLN GLN C . n 
C 3 377 SER 377 421 421 SER SER C . n 
C 3 378 THR 378 422 422 THR THR C . n 
C 3 379 ILE 379 423 423 ILE ILE C . n 
C 3 380 LEU 380 424 424 LEU LEU C . n 
C 3 381 VAL 381 425 425 VAL VAL C . n 
C 3 382 ASN 382 426 426 ASN ASN C . n 
C 3 383 ILE 383 427 427 ILE ILE C . n 
C 3 384 THR 384 428 428 THR THR C . n 
C 3 385 GLU 385 429 429 GLU GLU C . n 
C 3 386 LYS 386 430 430 LYS LYS C . n 
C 3 387 VAL 387 431 431 VAL VAL C . n 
C 3 388 TYR 388 432 ?   ?   ?   C . n 
C 3 389 PRO 389 433 ?   ?   ?   C . n 
C 3 390 HIS 390 434 ?   ?   ?   C . n 
C 3 391 THR 391 435 ?   ?   ?   C . n 
C 3 392 PRO 392 436 ?   ?   ?   C . n 
C 3 393 THR 393 437 ?   ?   ?   C . n 
C 3 394 SER 394 438 ?   ?   ?   C . n 
C 3 395 PHE 395 439 ?   ?   ?   C . n 
C 3 396 LYS 396 440 ?   ?   ?   C . n 
C 3 397 VAL 397 441 ?   ?   ?   C . n 
C 3 398 LYS 398 442 ?   ?   ?   C . n 
C 3 399 ASP 399 443 ?   ?   ?   C . n 
C 3 400 ILE 400 444 ?   ?   ?   C . n 
C 3 401 ASN 401 445 ?   ?   ?   C . n 
C 3 402 SER 402 446 ?   ?   ?   C . n 
C 3 403 THR 403 447 ?   ?   ?   C . n 
C 3 404 ALA 404 448 ?   ?   ?   C . n 
C 3 405 VAL 405 449 ?   ?   ?   C . n 
C 3 406 LYS 406 450 ?   ?   ?   C . n 
C 3 407 LEU 407 451 ?   ?   ?   C . n 
C 3 408 SER 408 452 ?   ?   ?   C . n 
C 3 409 TRP 409 453 ?   ?   ?   C . n 
C 3 410 HIS 410 454 ?   ?   ?   C . n 
C 3 411 LEU 411 455 ?   ?   ?   C . n 
C 3 412 PRO 412 456 ?   ?   ?   C . n 
C 3 413 GLY 413 457 ?   ?   ?   C . n 
C 3 414 ASN 414 458 ?   ?   ?   C . n 
C 3 415 PHE 415 459 ?   ?   ?   C . n 
C 3 416 ALA 416 460 ?   ?   ?   C . n 
C 3 417 LYS 417 461 ?   ?   ?   C . n 
C 3 418 ILE 418 462 ?   ?   ?   C . n 
C 3 419 ASN 419 463 ?   ?   ?   C . n 
C 3 420 PHE 420 464 ?   ?   ?   C . n 
C 3 421 LEU 421 465 ?   ?   ?   C . n 
C 3 422 CYS 422 466 ?   ?   ?   C . n 
C 3 423 GLU 423 467 ?   ?   ?   C . n 
C 3 424 ILE 424 468 ?   ?   ?   C . n 
C 3 425 GLU 425 469 ?   ?   ?   C . n 
C 3 426 ILE 426 470 ?   ?   ?   C . n 
C 3 427 LYS 427 471 ?   ?   ?   C . n 
C 3 428 LYS 428 472 ?   ?   ?   C . n 
C 3 429 SER 429 473 ?   ?   ?   C . n 
C 3 430 ASN 430 474 ?   ?   ?   C . n 
C 3 431 SER 431 475 ?   ?   ?   C . n 
C 3 432 VAL 432 476 ?   ?   ?   C . n 
C 3 433 GLN 433 477 ?   ?   ?   C . n 
C 3 434 GLU 434 478 ?   ?   ?   C . n 
C 3 435 GLN 435 479 ?   ?   ?   C . n 
C 3 436 ARG 436 480 ?   ?   ?   C . n 
C 3 437 ASN 437 481 ?   ?   ?   C . n 
C 3 438 VAL 438 482 ?   ?   ?   C . n 
C 3 439 THR 439 483 ?   ?   ?   C . n 
C 3 440 ILE 440 484 ?   ?   ?   C . n 
C 3 441 LYS 441 485 ?   ?   ?   C . n 
C 3 442 GLY 442 486 ?   ?   ?   C . n 
C 3 443 VAL 443 487 ?   ?   ?   C . n 
C 3 444 GLU 444 488 ?   ?   ?   C . n 
C 3 445 ASN 445 489 ?   ?   ?   C . n 
C 3 446 SER 446 490 ?   ?   ?   C . n 
C 3 447 SER 447 491 ?   ?   ?   C . n 
C 3 448 TYR 448 492 ?   ?   ?   C . n 
C 3 449 LEU 449 493 ?   ?   ?   C . n 
C 3 450 VAL 450 494 ?   ?   ?   C . n 
C 3 451 ALA 451 495 ?   ?   ?   C . n 
C 3 452 LEU 452 496 ?   ?   ?   C . n 
C 3 453 ASP 453 497 ?   ?   ?   C . n 
C 3 454 LYS 454 498 ?   ?   ?   C . n 
C 3 455 LEU 455 499 ?   ?   ?   C . n 
C 3 456 ASN 456 500 ?   ?   ?   C . n 
C 3 457 PRO 457 501 ?   ?   ?   C . n 
C 3 458 TYR 458 502 ?   ?   ?   C . n 
C 3 459 THR 459 503 ?   ?   ?   C . n 
C 3 460 LEU 460 504 ?   ?   ?   C . n 
C 3 461 TYR 461 505 ?   ?   ?   C . n 
C 3 462 THR 462 506 ?   ?   ?   C . n 
C 3 463 PHE 463 507 ?   ?   ?   C . n 
C 3 464 ARG 464 508 ?   ?   ?   C . n 
C 3 465 ILE 465 509 ?   ?   ?   C . n 
C 3 466 ARG 466 510 ?   ?   ?   C . n 
C 3 467 CYS 467 511 ?   ?   ?   C . n 
C 3 468 SER 468 512 ?   ?   ?   C . n 
C 3 469 THR 469 513 ?   ?   ?   C . n 
C 3 470 GLU 470 514 ?   ?   ?   C . n 
C 3 471 THR 471 515 ?   ?   ?   C . n 
C 3 472 PHE 472 516 ?   ?   ?   C . n 
C 3 473 TRP 473 517 ?   ?   ?   C . n 
C 3 474 LYS 474 518 ?   ?   ?   C . n 
C 3 475 TRP 475 519 ?   ?   ?   C . n 
C 3 476 SER 476 520 ?   ?   ?   C . n 
C 3 477 LYS 477 521 ?   ?   ?   C . n 
C 3 478 TRP 478 522 ?   ?   ?   C . n 
C 3 479 SER 479 523 ?   ?   ?   C . n 
C 3 480 ASN 480 524 ?   ?   ?   C . n 
C 3 481 LYS 481 525 ?   ?   ?   C . n 
C 3 482 LYS 482 526 ?   ?   ?   C . n 
C 3 483 GLN 483 527 ?   ?   ?   C . n 
C 3 484 HIS 484 528 ?   ?   ?   C . n 
C 3 485 LEU 485 529 ?   ?   ?   C . n 
C 3 486 THR 486 530 ?   ?   ?   C . n 
C 3 487 THR 487 531 ?   ?   ?   C . n 
C 3 488 GLU 488 532 ?   ?   ?   C . n 
C 3 489 ALA 489 533 ?   ?   ?   C . n 
C 3 490 SER 490 534 ?   ?   ?   C . n 
C 3 491 PRO 491 535 ?   ?   ?   C . n 
C 3 492 SER 492 536 ?   ?   ?   C . n 
C 3 493 LYS 493 537 ?   ?   ?   C . n 
C 3 494 GLY 494 538 ?   ?   ?   C . n 
C 3 495 PRO 495 539 ?   ?   ?   C . n 
C 3 496 ASP 496 540 ?   ?   ?   C . n 
C 3 497 THR 497 541 ?   ?   ?   C . n 
C 3 498 TRP 498 542 ?   ?   ?   C . n 
C 3 499 ARG 499 543 ?   ?   ?   C . n 
C 3 500 GLU 500 544 ?   ?   ?   C . n 
C 3 501 TRP 501 545 ?   ?   ?   C . n 
C 3 502 SER 502 546 ?   ?   ?   C . n 
C 3 503 SER 503 547 ?   ?   ?   C . n 
C 3 504 ASP 504 548 ?   ?   ?   C . n 
C 3 505 GLY 505 549 ?   ?   ?   C . n 
C 3 506 LYS 506 550 ?   ?   ?   C . n 
C 3 507 ASN 507 551 ?   ?   ?   C . n 
C 3 508 LEU 508 552 ?   ?   ?   C . n 
C 3 509 ILE 509 553 ?   ?   ?   C . n 
C 3 510 ILE 510 554 ?   ?   ?   C . n 
C 3 511 TYR 511 555 ?   ?   ?   C . n 
C 3 512 TRP 512 556 ?   ?   ?   C . n 
C 3 513 LYS 513 557 ?   ?   ?   C . n 
C 3 514 PRO 514 558 ?   ?   ?   C . n 
C 3 515 LEU 515 559 ?   ?   ?   C . n 
C 3 516 PRO 516 560 ?   ?   ?   C . n 
C 3 517 ILE 517 561 ?   ?   ?   C . n 
C 3 518 ASN 518 562 ?   ?   ?   C . n 
C 3 519 GLU 519 563 ?   ?   ?   C . n 
C 3 520 ALA 520 564 ?   ?   ?   C . n 
C 3 521 ASN 521 565 ?   ?   ?   C . n 
C 3 522 GLY 522 566 ?   ?   ?   C . n 
C 3 523 LYS 523 567 ?   ?   ?   C . n 
C 3 524 ILE 524 568 ?   ?   ?   C . n 
C 3 525 LEU 525 569 ?   ?   ?   C . n 
C 3 526 SER 526 570 ?   ?   ?   C . n 
C 3 527 TYR 527 571 ?   ?   ?   C . n 
C 3 528 ASN 528 572 ?   ?   ?   C . n 
C 3 529 VAL 529 573 ?   ?   ?   C . n 
C 3 530 SER 530 574 ?   ?   ?   C . n 
C 3 531 CYS 531 575 ?   ?   ?   C . n 
C 3 532 SER 532 576 ?   ?   ?   C . n 
C 3 533 SER 533 577 ?   ?   ?   C . n 
C 3 534 ASP 534 578 ?   ?   ?   C . n 
C 3 535 GLU 535 579 ?   ?   ?   C . n 
C 3 536 GLU 536 580 ?   ?   ?   C . n 
C 3 537 THR 537 581 ?   ?   ?   C . n 
C 3 538 GLN 538 582 ?   ?   ?   C . n 
C 3 539 SER 539 583 ?   ?   ?   C . n 
C 3 540 LEU 540 584 ?   ?   ?   C . n 
C 3 541 SER 541 585 ?   ?   ?   C . n 
C 3 542 GLU 542 586 ?   ?   ?   C . n 
C 3 543 ILE 543 587 ?   ?   ?   C . n 
C 3 544 PRO 544 588 ?   ?   ?   C . n 
C 3 545 ASP 545 589 ?   ?   ?   C . n 
C 3 546 PRO 546 590 ?   ?   ?   C . n 
C 3 547 GLN 547 591 ?   ?   ?   C . n 
C 3 548 HIS 548 592 ?   ?   ?   C . n 
C 3 549 LYS 549 593 ?   ?   ?   C . n 
C 3 550 ALA 550 594 ?   ?   ?   C . n 
C 3 551 GLU 551 595 ?   ?   ?   C . n 
C 3 552 ILE 552 596 ?   ?   ?   C . n 
C 3 553 ARG 553 597 ?   ?   ?   C . n 
C 3 554 LEU 554 598 ?   ?   ?   C . n 
C 3 555 ASP 555 599 ?   ?   ?   C . n 
C 3 556 LYS 556 600 ?   ?   ?   C . n 
C 3 557 ASN 557 601 ?   ?   ?   C . n 
C 3 558 ASP 558 602 ?   ?   ?   C . n 
C 3 559 TYR 559 603 ?   ?   ?   C . n 
C 3 560 ILE 560 604 ?   ?   ?   C . n 
C 3 561 ILE 561 605 ?   ?   ?   C . n 
C 3 562 SER 562 606 ?   ?   ?   C . n 
C 3 563 VAL 563 607 ?   ?   ?   C . n 
C 3 564 VAL 564 608 ?   ?   ?   C . n 
C 3 565 ALA 565 609 ?   ?   ?   C . n 
C 3 566 LYS 566 610 ?   ?   ?   C . n 
C 3 567 ASN 567 611 ?   ?   ?   C . n 
C 3 568 SER 568 612 ?   ?   ?   C . n 
C 3 569 VAL 569 613 ?   ?   ?   C . n 
C 3 570 GLY 570 614 ?   ?   ?   C . n 
C 3 571 SER 571 615 ?   ?   ?   C . n 
C 3 572 SER 572 616 ?   ?   ?   C . n 
C 3 573 PRO 573 617 ?   ?   ?   C . n 
C 3 574 PRO 574 618 ?   ?   ?   C . n 
C 3 575 SER 575 619 ?   ?   ?   C . n 
C 3 576 LYS 576 620 ?   ?   ?   C . n 
C 3 577 ILE 577 621 ?   ?   ?   C . n 
C 3 578 ALA 578 622 ?   ?   ?   C . n 
C 3 579 SER 579 623 ?   ?   ?   C . n 
C 3 580 MET 580 624 ?   ?   ?   C . n 
C 3 581 GLU 581 625 ?   ?   ?   C . n 
C 3 582 ILE 582 626 ?   ?   ?   C . n 
C 3 583 PRO 583 627 ?   ?   ?   C . n 
C 3 584 ASN 584 628 ?   ?   ?   C . n 
C 3 585 ASP 585 629 ?   ?   ?   C . n 
C 3 586 ASP 586 630 ?   ?   ?   C . n 
C 3 587 LEU 587 631 ?   ?   ?   C . n 
C 3 588 LYS 588 632 ?   ?   ?   C . n 
C 3 589 ILE 589 633 ?   ?   ?   C . n 
C 3 590 GLU 590 634 ?   ?   ?   C . n 
C 3 591 GLN 591 635 ?   ?   ?   C . n 
C 3 592 VAL 592 636 ?   ?   ?   C . n 
C 3 593 VAL 593 637 ?   ?   ?   C . n 
C 3 594 GLY 594 638 ?   ?   ?   C . n 
C 3 595 MET 595 639 ?   ?   ?   C . n 
C 3 596 GLY 596 640 ?   ?   ?   C . n 
C 3 597 LYS 597 641 ?   ?   ?   C . n 
C 3 598 GLY 598 642 ?   ?   ?   C . n 
C 3 599 ILE 599 643 ?   ?   ?   C . n 
C 3 600 LEU 600 644 ?   ?   ?   C . n 
C 3 601 LEU 601 645 ?   ?   ?   C . n 
C 3 602 THR 602 646 ?   ?   ?   C . n 
C 3 603 TRP 603 647 ?   ?   ?   C . n 
C 3 604 HIS 604 648 ?   ?   ?   C . n 
C 3 605 TYR 605 649 ?   ?   ?   C . n 
C 3 606 ASP 606 650 ?   ?   ?   C . n 
C 3 607 PRO 607 651 ?   ?   ?   C . n 
C 3 608 ASN 608 652 ?   ?   ?   C . n 
C 3 609 MET 609 653 ?   ?   ?   C . n 
C 3 610 THR 610 654 ?   ?   ?   C . n 
C 3 611 CYS 611 655 ?   ?   ?   C . n 
C 3 612 ASP 612 656 ?   ?   ?   C . n 
C 3 613 TYR 613 657 ?   ?   ?   C . n 
C 3 614 VAL 614 658 ?   ?   ?   C . n 
C 3 615 ILE 615 659 ?   ?   ?   C . n 
C 3 616 LYS 616 660 ?   ?   ?   C . n 
C 3 617 TRP 617 661 ?   ?   ?   C . n 
C 3 618 CYS 618 662 ?   ?   ?   C . n 
C 3 619 ASN 619 663 ?   ?   ?   C . n 
C 3 620 SER 620 664 ?   ?   ?   C . n 
C 3 621 SER 621 665 ?   ?   ?   C . n 
C 3 622 ARG 622 666 ?   ?   ?   C . n 
C 3 623 SER 623 667 ?   ?   ?   C . n 
C 3 624 GLU 624 668 ?   ?   ?   C . n 
C 3 625 PRO 625 669 ?   ?   ?   C . n 
C 3 626 CYS 626 670 ?   ?   ?   C . n 
C 3 627 LEU 627 671 ?   ?   ?   C . n 
C 3 628 MET 628 672 ?   ?   ?   C . n 
C 3 629 ASP 629 673 ?   ?   ?   C . n 
C 3 630 TRP 630 674 ?   ?   ?   C . n 
C 3 631 ARG 631 675 ?   ?   ?   C . n 
C 3 632 LYS 632 676 ?   ?   ?   C . n 
C 3 633 VAL 633 677 ?   ?   ?   C . n 
C 3 634 PRO 634 678 ?   ?   ?   C . n 
C 3 635 SER 635 679 ?   ?   ?   C . n 
C 3 636 ASN 636 680 ?   ?   ?   C . n 
C 3 637 SER 637 681 ?   ?   ?   C . n 
C 3 638 THR 638 682 ?   ?   ?   C . n 
C 3 639 GLU 639 683 ?   ?   ?   C . n 
C 3 640 THR 640 684 ?   ?   ?   C . n 
C 3 641 VAL 641 685 ?   ?   ?   C . n 
C 3 642 ILE 642 686 ?   ?   ?   C . n 
C 3 643 GLU 643 687 ?   ?   ?   C . n 
C 3 644 SER 644 688 ?   ?   ?   C . n 
C 3 645 ASP 645 689 ?   ?   ?   C . n 
C 3 646 GLU 646 690 ?   ?   ?   C . n 
C 3 647 PHE 647 691 ?   ?   ?   C . n 
C 3 648 ARG 648 692 ?   ?   ?   C . n 
C 3 649 PRO 649 693 ?   ?   ?   C . n 
C 3 650 GLY 650 694 ?   ?   ?   C . n 
C 3 651 ILE 651 695 ?   ?   ?   C . n 
C 3 652 ARG 652 696 ?   ?   ?   C . n 
C 3 653 TYR 653 697 ?   ?   ?   C . n 
C 3 654 ASN 654 698 ?   ?   ?   C . n 
C 3 655 PHE 655 699 ?   ?   ?   C . n 
C 3 656 PHE 656 700 ?   ?   ?   C . n 
C 3 657 LEU 657 701 ?   ?   ?   C . n 
C 3 658 TYR 658 702 ?   ?   ?   C . n 
C 3 659 GLY 659 703 ?   ?   ?   C . n 
C 3 660 CYS 660 704 ?   ?   ?   C . n 
C 3 661 ARG 661 705 ?   ?   ?   C . n 
C 3 662 ASN 662 706 ?   ?   ?   C . n 
C 3 663 GLN 663 707 ?   ?   ?   C . n 
C 3 664 GLY 664 708 ?   ?   ?   C . n 
C 3 665 TYR 665 709 ?   ?   ?   C . n 
C 3 666 GLN 666 710 ?   ?   ?   C . n 
C 3 667 LEU 667 711 ?   ?   ?   C . n 
C 3 668 LEU 668 712 ?   ?   ?   C . n 
C 3 669 ARG 669 713 ?   ?   ?   C . n 
C 3 670 SER 670 714 ?   ?   ?   C . n 
C 3 671 MET 671 715 ?   ?   ?   C . n 
C 3 672 ILE 672 716 ?   ?   ?   C . n 
C 3 673 GLY 673 717 ?   ?   ?   C . n 
C 3 674 TYR 674 718 ?   ?   ?   C . n 
C 3 675 ILE 675 719 ?   ?   ?   C . n 
C 3 676 GLU 676 720 ?   ?   ?   C . n 
C 3 677 GLU 677 721 ?   ?   ?   C . n 
C 3 678 LEU 678 722 ?   ?   ?   C . n 
C 3 679 ALA 679 723 ?   ?   ?   C . n 
C 3 680 PRO 680 724 ?   ?   ?   C . n 
C 3 681 ILE 681 725 ?   ?   ?   C . n 
C 3 682 VAL 682 726 ?   ?   ?   C . n 
C 3 683 ALA 683 727 ?   ?   ?   C . n 
C 3 684 PRO 684 728 ?   ?   ?   C . n 
C 3 685 ASN 685 729 ?   ?   ?   C . n 
C 3 686 PHE 686 730 ?   ?   ?   C . n 
C 3 687 THR 687 731 ?   ?   ?   C . n 
C 3 688 VAL 688 732 ?   ?   ?   C . n 
C 3 689 GLU 689 733 ?   ?   ?   C . n 
C 3 690 ASP 690 734 ?   ?   ?   C . n 
C 3 691 THR 691 735 ?   ?   ?   C . n 
C 3 692 SER 692 736 ?   ?   ?   C . n 
C 3 693 ALA 693 737 ?   ?   ?   C . n 
C 3 694 ASP 694 738 ?   ?   ?   C . n 
C 3 695 SER 695 739 ?   ?   ?   C . n 
C 3 696 ILE 696 740 ?   ?   ?   C . n 
C 3 697 LEU 697 741 ?   ?   ?   C . n 
C 3 698 VAL 698 742 ?   ?   ?   C . n 
C 3 699 LYS 699 743 ?   ?   ?   C . n 
C 3 700 TRP 700 744 ?   ?   ?   C . n 
C 3 701 GLU 701 745 ?   ?   ?   C . n 
C 3 702 ASP 702 746 ?   ?   ?   C . n 
C 3 703 ILE 703 747 ?   ?   ?   C . n 
C 3 704 PRO 704 748 ?   ?   ?   C . n 
C 3 705 VAL 705 749 ?   ?   ?   C . n 
C 3 706 GLU 706 750 ?   ?   ?   C . n 
C 3 707 GLU 707 751 ?   ?   ?   C . n 
C 3 708 LEU 708 752 ?   ?   ?   C . n 
C 3 709 ARG 709 753 ?   ?   ?   C . n 
C 3 710 GLY 710 754 ?   ?   ?   C . n 
C 3 711 PHE 711 755 ?   ?   ?   C . n 
C 3 712 LEU 712 756 ?   ?   ?   C . n 
C 3 713 ARG 713 757 ?   ?   ?   C . n 
C 3 714 GLY 714 758 ?   ?   ?   C . n 
C 3 715 TYR 715 759 ?   ?   ?   C . n 
C 3 716 LEU 716 760 ?   ?   ?   C . n 
C 3 717 PHE 717 761 ?   ?   ?   C . n 
C 3 718 TYR 718 762 ?   ?   ?   C . n 
C 3 719 PHE 719 763 ?   ?   ?   C . n 
C 3 720 GLY 720 764 ?   ?   ?   C . n 
C 3 721 LYS 721 765 ?   ?   ?   C . n 
C 3 722 GLY 722 766 ?   ?   ?   C . n 
C 3 723 GLU 723 767 ?   ?   ?   C . n 
C 3 724 ARG 724 768 ?   ?   ?   C . n 
C 3 725 ASP 725 769 ?   ?   ?   C . n 
C 3 726 THR 726 770 ?   ?   ?   C . n 
C 3 727 SER 727 771 ?   ?   ?   C . n 
C 3 728 LYS 728 772 ?   ?   ?   C . n 
C 3 729 MET 729 773 ?   ?   ?   C . n 
C 3 730 ARG 730 774 ?   ?   ?   C . n 
C 3 731 VAL 731 775 ?   ?   ?   C . n 
C 3 732 LEU 732 776 ?   ?   ?   C . n 
C 3 733 GLU 733 777 ?   ?   ?   C . n 
C 3 734 SER 734 778 ?   ?   ?   C . n 
C 3 735 GLY 735 779 ?   ?   ?   C . n 
C 3 736 ARG 736 780 ?   ?   ?   C . n 
C 3 737 SER 737 781 ?   ?   ?   C . n 
C 3 738 ASP 738 782 ?   ?   ?   C . n 
C 3 739 ILE 739 783 ?   ?   ?   C . n 
C 3 740 LYS 740 784 ?   ?   ?   C . n 
C 3 741 VAL 741 785 ?   ?   ?   C . n 
C 3 742 LYS 742 786 ?   ?   ?   C . n 
C 3 743 ASN 743 787 ?   ?   ?   C . n 
C 3 744 ILE 744 788 ?   ?   ?   C . n 
C 3 745 THR 745 789 ?   ?   ?   C . n 
C 3 746 ASP 746 790 ?   ?   ?   C . n 
C 3 747 ILE 747 791 ?   ?   ?   C . n 
C 3 748 SER 748 792 ?   ?   ?   C . n 
C 3 749 GLN 749 793 ?   ?   ?   C . n 
C 3 750 LYS 750 794 ?   ?   ?   C . n 
C 3 751 THR 751 795 ?   ?   ?   C . n 
C 3 752 LEU 752 796 ?   ?   ?   C . n 
C 3 753 ARG 753 797 ?   ?   ?   C . n 
C 3 754 ILE 754 798 ?   ?   ?   C . n 
C 3 755 ALA 755 799 ?   ?   ?   C . n 
C 3 756 ASP 756 800 ?   ?   ?   C . n 
C 3 757 LEU 757 801 ?   ?   ?   C . n 
C 3 758 GLN 758 802 ?   ?   ?   C . n 
C 3 759 GLY 759 803 ?   ?   ?   C . n 
C 3 760 LYS 760 804 ?   ?   ?   C . n 
C 3 761 THR 761 805 ?   ?   ?   C . n 
C 3 762 SER 762 806 ?   ?   ?   C . n 
C 3 763 TYR 763 807 ?   ?   ?   C . n 
C 3 764 HIS 764 808 ?   ?   ?   C . n 
C 3 765 LEU 765 809 ?   ?   ?   C . n 
C 3 766 VAL 766 810 ?   ?   ?   C . n 
C 3 767 LEU 767 811 ?   ?   ?   C . n 
C 3 768 ARG 768 812 ?   ?   ?   C . n 
C 3 769 ALA 769 813 ?   ?   ?   C . n 
C 3 770 TYR 770 814 ?   ?   ?   C . n 
C 3 771 THR 771 815 ?   ?   ?   C . n 
C 3 772 ASP 772 816 ?   ?   ?   C . n 
C 3 773 GLY 773 817 ?   ?   ?   C . n 
C 3 774 GLY 774 818 ?   ?   ?   C . n 
C 3 775 VAL 775 819 ?   ?   ?   C . n 
C 3 776 GLY 776 820 ?   ?   ?   C . n 
C 3 777 PRO 777 821 ?   ?   ?   C . n 
C 3 778 GLU 778 822 ?   ?   ?   C . n 
C 3 779 LYS 779 823 ?   ?   ?   C . n 
C 3 780 SER 780 824 ?   ?   ?   C . n 
C 3 781 MET 781 825 ?   ?   ?   C . n 
C 3 782 TYR 782 826 ?   ?   ?   C . n 
C 3 783 VAL 783 827 ?   ?   ?   C . n 
C 3 784 VAL 784 828 ?   ?   ?   C . n 
C 3 785 THR 785 829 ?   ?   ?   C . n 
C 3 786 LYS 786 830 ?   ?   ?   C . n 
C 3 787 GLU 787 831 ?   ?   ?   C . n 
C 3 788 ASN 788 832 ?   ?   ?   C . n 
C 3 789 SER 789 833 ?   ?   ?   C . n 
C 3 790 GLU 790 834 ?   ?   ?   C . n 
C 3 791 GLN 791 835 ?   ?   ?   C . n 
C 3 792 LYS 792 836 ?   ?   ?   C . n 
C 3 793 LEU 793 837 ?   ?   ?   C . n 
C 3 794 ILE 794 838 ?   ?   ?   C . n 
C 3 795 SER 795 839 ?   ?   ?   C . n 
C 3 796 GLU 796 840 ?   ?   ?   C . n 
C 3 797 GLU 797 841 ?   ?   ?   C . n 
C 3 798 ASP 798 842 ?   ?   ?   C . n 
C 3 799 LEU 799 843 ?   ?   ?   C . n 
C 3 800 GLY 800 844 ?   ?   ?   C . n 
C 3 801 GLY 801 845 ?   ?   ?   C . n 
C 3 802 GLU 802 846 ?   ?   ?   C . n 
C 3 803 GLN 803 847 ?   ?   ?   C . n 
C 3 804 LYS 804 848 ?   ?   ?   C . n 
C 3 805 LEU 805 849 ?   ?   ?   C . n 
C 3 806 ILE 806 850 ?   ?   ?   C . n 
C 3 807 SER 807 851 ?   ?   ?   C . n 
C 3 808 GLU 808 852 ?   ?   ?   C . n 
C 3 809 GLU 809 853 ?   ?   ?   C . n 
C 3 810 ASP 810 854 ?   ?   ?   C . n 
C 3 811 LEU 811 855 ?   ?   ?   C . n 
C 3 812 HIS 812 856 ?   ?   ?   C . n 
C 3 813 HIS 813 857 ?   ?   ?   C . n 
C 3 814 HIS 814 858 ?   ?   ?   C . n 
C 3 815 HIS 815 859 ?   ?   ?   C . n 
C 3 816 HIS 816 860 ?   ?   ?   C . n 
C 3 817 HIS 817 861 ?   ?   ?   C . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
D 4 NAG 1 D NAG 1 A NAG 1104 n 
D 4 NAG 2 D NAG 2 A NAG 1105 n 
E 4 NAG 1 E NAG 1 C NAG 1104 n 
E 4 NAG 2 E NAG 2 C NAG 1105 n 
F 4 NAG 1 F NAG 1 C NAG 1108 n 
F 4 NAG 2 F NAG 2 C NAG 1109 n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
G 5 NAG 1 701 991  NAG NAG B . 
H 5 NAG 1 702 993  NAG NAG B . 
I 5 NAG 1 703 996  NAG NAG B . 
J 5 NAG 1 901 1110 NAG NAG C . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8V2A 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8V2A 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8V2A 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8V2A 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002  ? 4617 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.470  ? 6259 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 23.165 ? 655  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.040  ? 729  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 793  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8V2A 
_struct.title                        'Cryo-EM structure of human type I OSM receptor complex: model for assembly core region' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8V2A 
_struct_keywords.text            'cytokine signaling, OSM, gp130, LIFR, CYTOKINE, CYTOKINE-RECEPTOR complex' 
_struct_keywords.pdbx_keywords   CYTOKINE/RECEPTOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 5 ? 
J N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ONCM_HUMAN  P13725 ? 1 
;AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGC
VLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAF
QRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRR
;
26 
2 UNP IL6RB_HUMAN P40189 ? 2 
;ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLT
CNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSC
TVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYR
TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ
GYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD
GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSL
TSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIE
;
23 
3 UNP LIFR_HUMAN  P42702 ? 3 
;QKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSK
FTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWS
WASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGH
TNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGP
RATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDI
NSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSN
KKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYI
ISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTET
VIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFG
KGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS
;
45 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8V2A A 1 ? 196 ? P13725 26 ? 221 ? 26 221 
2 2 8V2A B 1 ? 597 ? P40189 23 ? 619 ? 23 619 
3 3 8V2A C 1 ? 789 ? P42702 45 ? 833 ? 45 833 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8V2A GLU B 598 ? UNP P40189 ? ? 'expression tag' 620 1  
2 8V2A GLN B 599 ? UNP P40189 ? ? 'expression tag' 621 2  
2 8V2A LYS B 600 ? UNP P40189 ? ? 'expression tag' 622 3  
2 8V2A LEU B 601 ? UNP P40189 ? ? 'expression tag' 623 4  
2 8V2A ILE B 602 ? UNP P40189 ? ? 'expression tag' 624 5  
2 8V2A SER B 603 ? UNP P40189 ? ? 'expression tag' 625 6  
2 8V2A GLU B 604 ? UNP P40189 ? ? 'expression tag' 626 7  
2 8V2A GLU B 605 ? UNP P40189 ? ? 'expression tag' 627 8  
2 8V2A ASP B 606 ? UNP P40189 ? ? 'expression tag' 628 9  
2 8V2A LEU B 607 ? UNP P40189 ? ? 'expression tag' 629 10 
2 8V2A GLY B 608 ? UNP P40189 ? ? 'expression tag' 630 11 
2 8V2A GLY B 609 ? UNP P40189 ? ? 'expression tag' 631 12 
2 8V2A GLU B 610 ? UNP P40189 ? ? 'expression tag' 632 13 
2 8V2A GLN B 611 ? UNP P40189 ? ? 'expression tag' 633 14 
2 8V2A LYS B 612 ? UNP P40189 ? ? 'expression tag' 634 15 
2 8V2A LEU B 613 ? UNP P40189 ? ? 'expression tag' 635 16 
2 8V2A ILE B 614 ? UNP P40189 ? ? 'expression tag' 636 17 
2 8V2A SER B 615 ? UNP P40189 ? ? 'expression tag' 637 18 
2 8V2A GLU B 616 ? UNP P40189 ? ? 'expression tag' 638 19 
2 8V2A GLU B 617 ? UNP P40189 ? ? 'expression tag' 639 20 
2 8V2A ASP B 618 ? UNP P40189 ? ? 'expression tag' 640 21 
2 8V2A LEU B 619 ? UNP P40189 ? ? 'expression tag' 641 22 
2 8V2A HIS B 620 ? UNP P40189 ? ? 'expression tag' 642 23 
2 8V2A HIS B 621 ? UNP P40189 ? ? 'expression tag' 643 24 
2 8V2A HIS B 622 ? UNP P40189 ? ? 'expression tag' 644 25 
2 8V2A HIS B 623 ? UNP P40189 ? ? 'expression tag' 645 26 
2 8V2A HIS B 624 ? UNP P40189 ? ? 'expression tag' 646 27 
2 8V2A HIS B 625 ? UNP P40189 ? ? 'expression tag' 647 28 
3 8V2A GLU C 790 ? UNP P42702 ? ? 'expression tag' 834 29 
3 8V2A GLN C 791 ? UNP P42702 ? ? 'expression tag' 835 30 
3 8V2A LYS C 792 ? UNP P42702 ? ? 'expression tag' 836 31 
3 8V2A LEU C 793 ? UNP P42702 ? ? 'expression tag' 837 32 
3 8V2A ILE C 794 ? UNP P42702 ? ? 'expression tag' 838 33 
3 8V2A SER C 795 ? UNP P42702 ? ? 'expression tag' 839 34 
3 8V2A GLU C 796 ? UNP P42702 ? ? 'expression tag' 840 35 
3 8V2A GLU C 797 ? UNP P42702 ? ? 'expression tag' 841 36 
3 8V2A ASP C 798 ? UNP P42702 ? ? 'expression tag' 842 37 
3 8V2A LEU C 799 ? UNP P42702 ? ? 'expression tag' 843 38 
3 8V2A GLY C 800 ? UNP P42702 ? ? 'expression tag' 844 39 
3 8V2A GLY C 801 ? UNP P42702 ? ? 'expression tag' 845 40 
3 8V2A GLU C 802 ? UNP P42702 ? ? 'expression tag' 846 41 
3 8V2A GLN C 803 ? UNP P42702 ? ? 'expression tag' 847 42 
3 8V2A LYS C 804 ? UNP P42702 ? ? 'expression tag' 848 43 
3 8V2A LEU C 805 ? UNP P42702 ? ? 'expression tag' 849 44 
3 8V2A ILE C 806 ? UNP P42702 ? ? 'expression tag' 850 45 
3 8V2A SER C 807 ? UNP P42702 ? ? 'expression tag' 851 46 
3 8V2A GLU C 808 ? UNP P42702 ? ? 'expression tag' 852 47 
3 8V2A GLU C 809 ? UNP P42702 ? ? 'expression tag' 853 48 
3 8V2A ASP C 810 ? UNP P42702 ? ? 'expression tag' 854 49 
3 8V2A LEU C 811 ? UNP P42702 ? ? 'expression tag' 855 50 
3 8V2A HIS C 812 ? UNP P42702 ? ? 'expression tag' 856 51 
3 8V2A HIS C 813 ? UNP P42702 ? ? 'expression tag' 857 52 
3 8V2A HIS C 814 ? UNP P42702 ? ? 'expression tag' 858 53 
3 8V2A HIS C 815 ? UNP P42702 ? ? 'expression tag' 859 54 
3 8V2A HIS C 816 ? UNP P42702 ? ? 'expression tag' 860 55 
3 8V2A HIS C 817 ? UNP P42702 ? ? 'expression tag' 861 56 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 9   ? GLN A 25  ? GLU A 34  GLN A 50  1 ? 17 
HELX_P HELX_P2  AA2 ASP A 26  ? GLN A 38  ? ASP A 51  GLN A 63  1 ? 13 
HELX_P HELX_P3  AA3 VAL A 42  ? HIS A 48  ? VAL A 67  HIS A 73  1 ? 7  
HELX_P HELX_P4  AA4 SER A 58  ? LEU A 65  ? SER A 83  LEU A 90  1 ? 8  
HELX_P HELX_P5  AA5 ARG A 68  ? LEU A 92  ? ARG A 93  LEU A 117 1 ? 25 
HELX_P HELX_P6  AA6 LYS A 94  ? GLY A 102 ? LYS A 119 GLY A 127 1 ? 9  
HELX_P HELX_P7  AA7 ILE A 105 ? ASP A 133 ? ILE A 130 ASP A 158 1 ? 29 
HELX_P HELX_P8  AA8 ASP A 158 ? TRP A 187 ? ASP A 183 TRP A 212 1 ? 30 
HELX_P HELX_P9  AA9 ASP B 193 ? TYR B 196 ? ASP B 215 TYR B 218 5 ? 4  
HELX_P HELX_P10 AB1 PRO B 225 ? VAL B 230 ? PRO B 247 VAL B 252 5 ? 6  
HELX_P HELX_P11 AB2 PRO B 251 ? ALA B 256 ? PRO B 273 ALA B 278 5 ? 6  
HELX_P HELX_P12 AB3 THR C 384 ? LYS C 386 ? THR C 428 LYS C 430 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 6   SG  ? ? ? 1_555 A CYS 127 SG ? ? A CYS 31  A CYS 152 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf2  disulf ?    ? A CYS 49  SG  ? ? ? 1_555 A CYS 167 SG ? ? A CYS 74  A CYS 192 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf3  disulf ?    ? B CYS 112 SG  ? ? ? 1_555 B CYS 122 SG ? ? B CYS 134 B CYS 144 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf4  disulf ?    ? B CYS 150 SG  ? ? ? 1_555 B CYS 160 SG ? ? B CYS 172 B CYS 182 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf5  disulf ?    ? C CYS 297 SG  ? ? ? 1_555 C CYS 307 SG ? ? C CYS 341 C CYS 351 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
covale1  covale one  ? A ASN 75  ND2 ? ? ? 1_555 D NAG .   C1 ? ? A ASN 100 D NAG 1   1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
covale2  covale one  ? B ASN 109 ND2 ? ? ? 1_555 G NAG .   C1 ? ? B ASN 131 B NAG 701 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
covale3  covale one  ? B ASN 135 ND2 ? ? ? 1_555 I NAG .   C1 ? ? B ASN 157 B NAG 703 1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation 
covale4  covale one  ? B ASN 205 ND2 ? ? ? 1_555 H NAG .   C1 ? ? B ASN 227 B NAG 702 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale5  covale one  ? C ASN 259 ND2 ? ? ? 1_555 J NAG .   C1 ? ? C ASN 303 C NAG 901 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale6  covale one  ? C ASN 363 ND2 ? ? ? 1_555 E NAG .   C1 ? ? C ASN 407 E NAG 1   1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
covale7  covale one  ? C ASN 382 ND2 ? ? ? 1_555 F NAG .   C1 ? ? C ASN 426 F NAG 1   1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation 
covale8  covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? D NAG 1   D NAG 2   1_555 ? ? ? ? ? ? ? 1.441 ? ?               
covale9  covale both ? E NAG .   O4  ? ? ? 1_555 E NAG .   C1 ? ? E NAG 1   E NAG 2   1_555 ? ? ? ? ? ? ? 1.440 ? ?               
covale10 covale both ? F NAG .   O4  ? ? ? 1_555 F NAG .   C1 ? ? F NAG 1   F NAG 2   1_555 ? ? ? ? ? ? ? 1.444 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG D .   ? ASN A 75  ? NAG D 1   ? 1_555 ASN A 100 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG E .   ? ASN C 363 ? NAG E 1   ? 1_555 ASN C 407 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG F .   ? ASN C 382 ? NAG F 1   ? 1_555 ASN C 426 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG G .   ? ASN B 109 ? NAG B 701 ? 1_555 ASN B 131 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG H .   ? ASN B 205 ? NAG B 702 ? 1_555 ASN B 227 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  NAG I .   ? ASN B 135 ? NAG B 703 ? 1_555 ASN B 157 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
7  NAG J .   ? ASN C 259 ? NAG C 901 ? 1_555 ASN C 303 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
8  CYS A 6   ? CYS A 127 ? CYS A 31  ? 1_555 CYS A 152 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS A 49  ? CYS A 167 ? CYS A 74  ? 1_555 CYS A 192 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS B 112 ? CYS B 122 ? CYS B 134 ? 1_555 CYS B 144 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS B 150 ? CYS B 160 ? CYS B 172 ? 1_555 CYS B 182 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS C 297 ? CYS C 307 ? CYS C 341 ? 1_555 CYS C 351 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PHE 
_struct_mon_prot_cis.label_seq_id           211 
_struct_mon_prot_cis.label_asym_id          C 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PHE 
_struct_mon_prot_cis.auth_seq_id            255 
_struct_mon_prot_cis.auth_asym_id           C 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    212 
_struct_mon_prot_cis.pdbx_label_asym_id_2   C 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     256 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    C 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -2.25 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 3 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 2 ? 
AA8 ? 4 ? 
AA9 ? 3 ? 
AB1 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? parallel      
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER B 159 ? THR B 161 ? SER B 181 THR B 183 
AA1 2 MET B 120 ? GLU B 123 ? MET B 142 GLU B 145 
AA1 3 SER B 111 ? ASN B 115 ? SER B 133 ASN B 137 
AA1 4 VAL B 198 ? LYS B 199 ? VAL B 220 LYS B 221 
AA2 1 LYS B 146 ? ASP B 149 ? LYS B 168 ASP B 171 
AA2 2 ASN B 135 ? GLU B 141 ? ASN B 157 GLU B 163 
AA2 3 ILE B 172 ? ASN B 180 ? ILE B 194 ASN B 202 
AA2 4 GLY B 183 ? THR B 186 ? GLY B 205 THR B 208 
AA3 1 LYS B 146 ? ASP B 149 ? LYS B 168 ASP B 171 
AA3 2 ASN B 135 ? GLU B 141 ? ASN B 157 GLU B 163 
AA3 3 ILE B 172 ? ASN B 180 ? ILE B 194 ASN B 202 
AA3 4 ILE B 190 ? PHE B 192 ? ILE B 212 PHE B 214 
AA4 1 HIS B 204 ? ILE B 209 ? HIS B 226 ILE B 231 
AA4 2 LEU B 218 ? THR B 223 ? LEU B 240 THR B 245 
AA4 3 SER B 261 ? VAL B 264 ? SER B 283 VAL B 286 
AA5 1 SER B 248 ? GLN B 249 ? SER B 270 GLN B 271 
AA5 2 LEU B 233 ? THR B 241 ? LEU B 255 THR B 263 
AA5 3 GLU B 272 ? LYS B 281 ? GLU B 294 LYS B 303 
AA5 4 ALA B 295 ? ILE B 298 ? ALA B 317 ILE B 320 
AA6 1 VAL C 210 ? PHE C 211 ? VAL C 254 PHE C 255 
AA6 2 ILE C 223 ? CYS C 227 ? ILE C 267 CYS C 271 
AA6 3 VAL C 253 ? ILE C 257 ? VAL C 297 ILE C 301 
AA6 4 ILE C 246 ? HIS C 247 ? ILE C 290 HIS C 291 
AA7 1 LYS C 215 ? LEU C 218 ? LYS C 259 LEU C 262 
AA7 2 ILE C 283 ? GLY C 286 ? ILE C 327 GLY C 330 
AA8 1 THR C 241 ? CYS C 243 ? THR C 285 CYS C 287 
AA8 2 SER C 235 ? ILE C 238 ? SER C 279 ILE C 282 
AA8 3 VAL C 270 ? THR C 273 ? VAL C 314 THR C 317 
AA8 4 ILE C 278 ? GLY C 280 ? ILE C 322 GLY C 324 
AA9 1 GLN C 293 ? THR C 299 ? GLN C 337 THR C 343 
AA9 2 GLU C 304 ? ASN C 310 ? GLU C 348 ASN C 354 
AA9 3 TYR C 349 ? GLN C 354 ? TYR C 393 GLN C 398 
AB1 1 TYR C 335 ? ARG C 337 ? TYR C 379 ARG C 381 
AB1 2 SER C 324 ? GLU C 329 ? SER C 368 GLU C 373 
AB1 3 ILE C 361 ? ASN C 370 ? ILE C 405 ASN C 414 
AB1 4 GLY C 373 ? ASN C 382 ? GLY C 417 ASN C 426 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O CYS B 160 ? O CYS B 182 N CYS B 122 ? N CYS B 144 
AA1 2 3 O GLU B 123 ? O GLU B 145 N SER B 111 ? N SER B 133 
AA1 3 4 N VAL B 114 ? N VAL B 136 O LYS B 199 ? O LYS B 221 
AA2 1 2 O PHE B 147 ? O PHE B 169 N SER B 140 ? N SER B 162 
AA2 2 3 N THR B 137 ? N THR B 159 O GLU B 177 ? O GLU B 199 
AA2 3 4 N ALA B 178 ? N ALA B 200 O VAL B 185 ? O VAL B 207 
AA3 1 2 O PHE B 147 ? O PHE B 169 N SER B 140 ? N SER B 162 
AA3 2 3 N THR B 137 ? N THR B 159 O GLU B 177 ? O GLU B 199 
AA3 3 4 N VAL B 174 ? N VAL B 196 O ILE B 190 ? O ILE B 212 
AA4 1 2 N ILE B 209 ? N ILE B 231 O LYS B 219 ? O LYS B 241 
AA4 2 3 N LEU B 220 ? N LEU B 242 O PHE B 262 ? O PHE B 284 
AA5 1 2 O SER B 248 ? O SER B 270 N TYR B 239 ? N TYR B 261 
AA5 2 3 N GLN B 238 ? N GLN B 260 O ARG B 276 ? O ARG B 298 
AA5 3 4 N TYR B 273 ? N TYR B 295 O GLY B 297 ? O GLY B 319 
AA6 1 2 N PHE C 211 ? N PHE C 255 O CYS C 226 ? O CYS C 270 
AA6 2 3 N ILE C 223 ? N ILE C 267 O ILE C 257 ? O ILE C 301 
AA6 3 4 O ALA C 254 ? O ALA C 298 N ILE C 246 ? N ILE C 290 
AA7 1 2 N ILE C 217 ? N ILE C 261 O PHE C 284 ? O PHE C 328 
AA8 1 2 O THR C 241 ? O THR C 285 N ILE C 238 ? N ILE C 282 
AA8 2 3 N LEU C 237 ? N LEU C 281 O VAL C 271 ? O VAL C 315 
AA8 3 4 N PHE C 272 ? N PHE C 316 O PHE C 279 ? O PHE C 323 
AA9 1 2 N ASN C 296 ? N ASN C 340 O SER C 308 ? O SER C 352 
AA9 2 3 N ILE C 305 ? N ILE C 349 O PHE C 353 ? O PHE C 397 
AB1 1 2 O VAL C 336 ? O VAL C 380 N LEU C 327 ? N LEU C 371 
AB1 2 3 N THR C 326 ? N THR C 370 O ASN C 367 ? O ASN C 411 
AB1 3 4 N TYR C 362 ? N TYR C 406 O VAL C 381 ? O VAL C 425 
# 
_pdbx_entry_details.entry_id                   8V2A 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER B 238 ? ? -140.04 10.22  
2 1 PHE B 292 ? ? 31.94   57.53  
3 1 PRO C 364 ? ? -83.41  43.23  
4 1 ARG C 365 ? ? -142.86 16.47  
5 1 ALA C 385 ? ? -59.59  109.20 
6 1 PRO C 415 ? ? -65.40  4.75   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8V2A 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8V2A 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.59 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               219837 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' COMPLEX 'Human OSM in complex with gp130 and LIFR' ? ? ? '1, 2, 3' 
2 1 RECOMBINANT        COMPLEX 'gp130 and LIFR'                           ? ? ? '2, 3'    
3 1 RECOMBINANT        COMPLEX 'Human OSM'                                ? ? ? 1         
# 
_em_imaging.entry_id                        8V2A 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1400 
_em_imaging.nominal_defocus_max             2600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8V2A 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8V2A 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              8V2A 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1    1 Y 1 A SER 160 ? A SER 135 
2    1 Y 1 A ASP 161 ? A ASP 136 
3    1 Y 1 A THR 162 ? A THR 137 
4    1 Y 1 A ALA 163 ? A ALA 138 
5    1 Y 1 A GLU 164 ? A GLU 139 
6    1 Y 1 A PRO 165 ? A PRO 140 
7    1 Y 1 A THR 166 ? A THR 141 
8    1 Y 1 A LYS 167 ? A LYS 142 
9    1 Y 1 A ALA 168 ? A ALA 143 
10   1 Y 1 A GLY 169 ? A GLY 144 
11   1 Y 1 A ARG 170 ? A ARG 145 
12   1 Y 1 A GLY 171 ? A GLY 146 
13   1 Y 1 A ALA 172 ? A ALA 147 
14   1 Y 1 A SER 173 ? A SER 148 
15   1 Y 1 A GLN 174 ? A GLN 149 
16   1 Y 1 A PRO 175 ? A PRO 150 
17   1 Y 1 A PRO 176 ? A PRO 151 
18   1 Y 1 A THR 177 ? A THR 152 
19   1 Y 1 A PRO 178 ? A PRO 153 
20   1 Y 1 A ASN 217 ? A ASN 192 
21   1 Y 1 A ARG 218 ? A ARG 193 
22   1 Y 1 A SER 219 ? A SER 194 
23   1 Y 1 A ARG 220 ? A ARG 195 
24   1 Y 1 A ARG 221 ? A ARG 196 
25   1 Y 1 B GLU 23  ? B GLU 1   
26   1 Y 1 B LEU 24  ? B LEU 2   
27   1 Y 1 B LEU 25  ? B LEU 3   
28   1 Y 1 B ASP 26  ? B ASP 4   
29   1 Y 1 B PRO 27  ? B PRO 5   
30   1 Y 1 B CYS 28  ? B CYS 6   
31   1 Y 1 B GLY 29  ? B GLY 7   
32   1 Y 1 B TYR 30  ? B TYR 8   
33   1 Y 1 B ILE 31  ? B ILE 9   
34   1 Y 1 B SER 32  ? B SER 10  
35   1 Y 1 B PRO 33  ? B PRO 11  
36   1 Y 1 B GLU 34  ? B GLU 12  
37   1 Y 1 B SER 35  ? B SER 13  
38   1 Y 1 B PRO 36  ? B PRO 14  
39   1 Y 1 B VAL 37  ? B VAL 15  
40   1 Y 1 B VAL 38  ? B VAL 16  
41   1 Y 1 B GLN 39  ? B GLN 17  
42   1 Y 1 B LEU 40  ? B LEU 18  
43   1 Y 1 B HIS 41  ? B HIS 19  
44   1 Y 1 B SER 42  ? B SER 20  
45   1 Y 1 B ASN 43  ? B ASN 21  
46   1 Y 1 B PHE 44  ? B PHE 22  
47   1 Y 1 B THR 45  ? B THR 23  
48   1 Y 1 B ALA 46  ? B ALA 24  
49   1 Y 1 B VAL 47  ? B VAL 25  
50   1 Y 1 B CYS 48  ? B CYS 26  
51   1 Y 1 B VAL 49  ? B VAL 27  
52   1 Y 1 B LEU 50  ? B LEU 28  
53   1 Y 1 B LYS 51  ? B LYS 29  
54   1 Y 1 B GLU 52  ? B GLU 30  
55   1 Y 1 B LYS 53  ? B LYS 31  
56   1 Y 1 B CYS 54  ? B CYS 32  
57   1 Y 1 B MET 55  ? B MET 33  
58   1 Y 1 B ASP 56  ? B ASP 34  
59   1 Y 1 B TYR 57  ? B TYR 35  
60   1 Y 1 B PHE 58  ? B PHE 36  
61   1 Y 1 B HIS 59  ? B HIS 37  
62   1 Y 1 B VAL 60  ? B VAL 38  
63   1 Y 1 B ASN 61  ? B ASN 39  
64   1 Y 1 B ALA 62  ? B ALA 40  
65   1 Y 1 B ASN 63  ? B ASN 41  
66   1 Y 1 B TYR 64  ? B TYR 42  
67   1 Y 1 B ILE 65  ? B ILE 43  
68   1 Y 1 B VAL 66  ? B VAL 44  
69   1 Y 1 B TRP 67  ? B TRP 45  
70   1 Y 1 B LYS 68  ? B LYS 46  
71   1 Y 1 B THR 69  ? B THR 47  
72   1 Y 1 B ASN 70  ? B ASN 48  
73   1 Y 1 B HIS 71  ? B HIS 49  
74   1 Y 1 B PHE 72  ? B PHE 50  
75   1 Y 1 B THR 73  ? B THR 51  
76   1 Y 1 B ILE 74  ? B ILE 52  
77   1 Y 1 B PRO 75  ? B PRO 53  
78   1 Y 1 B LYS 76  ? B LYS 54  
79   1 Y 1 B GLU 77  ? B GLU 55  
80   1 Y 1 B GLN 78  ? B GLN 56  
81   1 Y 1 B TYR 79  ? B TYR 57  
82   1 Y 1 B THR 80  ? B THR 58  
83   1 Y 1 B ILE 81  ? B ILE 59  
84   1 Y 1 B ILE 82  ? B ILE 60  
85   1 Y 1 B ASN 83  ? B ASN 61  
86   1 Y 1 B ARG 84  ? B ARG 62  
87   1 Y 1 B THR 85  ? B THR 63  
88   1 Y 1 B ALA 86  ? B ALA 64  
89   1 Y 1 B SER 87  ? B SER 65  
90   1 Y 1 B SER 88  ? B SER 66  
91   1 Y 1 B VAL 89  ? B VAL 67  
92   1 Y 1 B THR 90  ? B THR 68  
93   1 Y 1 B PHE 91  ? B PHE 69  
94   1 Y 1 B THR 92  ? B THR 70  
95   1 Y 1 B ASP 93  ? B ASP 71  
96   1 Y 1 B ILE 94  ? B ILE 72  
97   1 Y 1 B ALA 95  ? B ALA 73  
98   1 Y 1 B SER 96  ? B SER 74  
99   1 Y 1 B LEU 97  ? B LEU 75  
100  1 Y 1 B ASN 98  ? B ASN 76  
101  1 Y 1 B ILE 99  ? B ILE 77  
102  1 Y 1 B GLN 100 ? B GLN 78  
103  1 Y 1 B LEU 101 ? B LEU 79  
104  1 Y 1 B THR 102 ? B THR 80  
105  1 Y 1 B CYS 103 ? B CYS 81  
106  1 Y 1 B ASN 104 ? B ASN 82  
107  1 Y 1 B ILE 105 ? B ILE 83  
108  1 Y 1 B LEU 106 ? B LEU 84  
109  1 Y 1 B THR 107 ? B THR 85  
110  1 Y 1 B PHE 108 ? B PHE 86  
111  1 Y 1 B GLY 109 ? B GLY 87  
112  1 Y 1 B GLN 110 ? B GLN 88  
113  1 Y 1 B LEU 111 ? B LEU 89  
114  1 Y 1 B GLU 112 ? B GLU 90  
115  1 Y 1 B GLN 113 ? B GLN 91  
116  1 Y 1 B ASN 114 ? B ASN 92  
117  1 Y 1 B VAL 115 ? B VAL 93  
118  1 Y 1 B TYR 116 ? B TYR 94  
119  1 Y 1 B GLY 117 ? B GLY 95  
120  1 Y 1 B ILE 118 ? B ILE 96  
121  1 Y 1 B THR 119 ? B THR 97  
122  1 Y 1 B ILE 120 ? B ILE 98  
123  1 Y 1 B ILE 121 ? B ILE 99  
124  1 Y 1 B SER 122 ? B SER 100 
125  1 Y 1 B GLY 123 ? B GLY 101 
126  1 Y 1 B LEU 124 ? B LEU 102 
127  1 Y 1 B ASP 324 ? B ASP 302 
128  1 Y 1 B ARG 325 ? B ARG 303 
129  1 Y 1 B PRO 326 ? B PRO 304 
130  1 Y 1 B SER 327 ? B SER 305 
131  1 Y 1 B LYS 328 ? B LYS 306 
132  1 Y 1 B ALA 329 ? B ALA 307 
133  1 Y 1 B PRO 330 ? B PRO 308 
134  1 Y 1 B SER 331 ? B SER 309 
135  1 Y 1 B PHE 332 ? B PHE 310 
136  1 Y 1 B TRP 333 ? B TRP 311 
137  1 Y 1 B TYR 334 ? B TYR 312 
138  1 Y 1 B LYS 335 ? B LYS 313 
139  1 Y 1 B ILE 336 ? B ILE 314 
140  1 Y 1 B ASP 337 ? B ASP 315 
141  1 Y 1 B PRO 338 ? B PRO 316 
142  1 Y 1 B SER 339 ? B SER 317 
143  1 Y 1 B HIS 340 ? B HIS 318 
144  1 Y 1 B THR 341 ? B THR 319 
145  1 Y 1 B GLN 342 ? B GLN 320 
146  1 Y 1 B GLY 343 ? B GLY 321 
147  1 Y 1 B TYR 344 ? B TYR 322 
148  1 Y 1 B ARG 345 ? B ARG 323 
149  1 Y 1 B THR 346 ? B THR 324 
150  1 Y 1 B VAL 347 ? B VAL 325 
151  1 Y 1 B GLN 348 ? B GLN 326 
152  1 Y 1 B LEU 349 ? B LEU 327 
153  1 Y 1 B VAL 350 ? B VAL 328 
154  1 Y 1 B TRP 351 ? B TRP 329 
155  1 Y 1 B LYS 352 ? B LYS 330 
156  1 Y 1 B THR 353 ? B THR 331 
157  1 Y 1 B LEU 354 ? B LEU 332 
158  1 Y 1 B PRO 355 ? B PRO 333 
159  1 Y 1 B PRO 356 ? B PRO 334 
160  1 Y 1 B PHE 357 ? B PHE 335 
161  1 Y 1 B GLU 358 ? B GLU 336 
162  1 Y 1 B ALA 359 ? B ALA 337 
163  1 Y 1 B ASN 360 ? B ASN 338 
164  1 Y 1 B GLY 361 ? B GLY 339 
165  1 Y 1 B LYS 362 ? B LYS 340 
166  1 Y 1 B ILE 363 ? B ILE 341 
167  1 Y 1 B LEU 364 ? B LEU 342 
168  1 Y 1 B ASP 365 ? B ASP 343 
169  1 Y 1 B TYR 366 ? B TYR 344 
170  1 Y 1 B GLU 367 ? B GLU 345 
171  1 Y 1 B VAL 368 ? B VAL 346 
172  1 Y 1 B THR 369 ? B THR 347 
173  1 Y 1 B LEU 370 ? B LEU 348 
174  1 Y 1 B THR 371 ? B THR 349 
175  1 Y 1 B ARG 372 ? B ARG 350 
176  1 Y 1 B TRP 373 ? B TRP 351 
177  1 Y 1 B LYS 374 ? B LYS 352 
178  1 Y 1 B SER 375 ? B SER 353 
179  1 Y 1 B HIS 376 ? B HIS 354 
180  1 Y 1 B LEU 377 ? B LEU 355 
181  1 Y 1 B GLN 378 ? B GLN 356 
182  1 Y 1 B ASN 379 ? B ASN 357 
183  1 Y 1 B TYR 380 ? B TYR 358 
184  1 Y 1 B THR 381 ? B THR 359 
185  1 Y 1 B VAL 382 ? B VAL 360 
186  1 Y 1 B ASN 383 ? B ASN 361 
187  1 Y 1 B ALA 384 ? B ALA 362 
188  1 Y 1 B THR 385 ? B THR 363 
189  1 Y 1 B LYS 386 ? B LYS 364 
190  1 Y 1 B LEU 387 ? B LEU 365 
191  1 Y 1 B THR 388 ? B THR 366 
192  1 Y 1 B VAL 389 ? B VAL 367 
193  1 Y 1 B ASN 390 ? B ASN 368 
194  1 Y 1 B LEU 391 ? B LEU 369 
195  1 Y 1 B THR 392 ? B THR 370 
196  1 Y 1 B ASN 393 ? B ASN 371 
197  1 Y 1 B ASP 394 ? B ASP 372 
198  1 Y 1 B ARG 395 ? B ARG 373 
199  1 Y 1 B TYR 396 ? B TYR 374 
200  1 Y 1 B LEU 397 ? B LEU 375 
201  1 Y 1 B ALA 398 ? B ALA 376 
202  1 Y 1 B THR 399 ? B THR 377 
203  1 Y 1 B LEU 400 ? B LEU 378 
204  1 Y 1 B THR 401 ? B THR 379 
205  1 Y 1 B VAL 402 ? B VAL 380 
206  1 Y 1 B ARG 403 ? B ARG 381 
207  1 Y 1 B ASN 404 ? B ASN 382 
208  1 Y 1 B LEU 405 ? B LEU 383 
209  1 Y 1 B VAL 406 ? B VAL 384 
210  1 Y 1 B GLY 407 ? B GLY 385 
211  1 Y 1 B LYS 408 ? B LYS 386 
212  1 Y 1 B SER 409 ? B SER 387 
213  1 Y 1 B ASP 410 ? B ASP 388 
214  1 Y 1 B ALA 411 ? B ALA 389 
215  1 Y 1 B ALA 412 ? B ALA 390 
216  1 Y 1 B VAL 413 ? B VAL 391 
217  1 Y 1 B LEU 414 ? B LEU 392 
218  1 Y 1 B THR 415 ? B THR 393 
219  1 Y 1 B ILE 416 ? B ILE 394 
220  1 Y 1 B PRO 417 ? B PRO 395 
221  1 Y 1 B ALA 418 ? B ALA 396 
222  1 Y 1 B CYS 419 ? B CYS 397 
223  1 Y 1 B ASP 420 ? B ASP 398 
224  1 Y 1 B PHE 421 ? B PHE 399 
225  1 Y 1 B GLN 422 ? B GLN 400 
226  1 Y 1 B ALA 423 ? B ALA 401 
227  1 Y 1 B THR 424 ? B THR 402 
228  1 Y 1 B HIS 425 ? B HIS 403 
229  1 Y 1 B PRO 426 ? B PRO 404 
230  1 Y 1 B VAL 427 ? B VAL 405 
231  1 Y 1 B MET 428 ? B MET 406 
232  1 Y 1 B ASP 429 ? B ASP 407 
233  1 Y 1 B LEU 430 ? B LEU 408 
234  1 Y 1 B LYS 431 ? B LYS 409 
235  1 Y 1 B ALA 432 ? B ALA 410 
236  1 Y 1 B PHE 433 ? B PHE 411 
237  1 Y 1 B PRO 434 ? B PRO 412 
238  1 Y 1 B LYS 435 ? B LYS 413 
239  1 Y 1 B ASP 436 ? B ASP 414 
240  1 Y 1 B ASN 437 ? B ASN 415 
241  1 Y 1 B MET 438 ? B MET 416 
242  1 Y 1 B LEU 439 ? B LEU 417 
243  1 Y 1 B TRP 440 ? B TRP 418 
244  1 Y 1 B VAL 441 ? B VAL 419 
245  1 Y 1 B GLU 442 ? B GLU 420 
246  1 Y 1 B TRP 443 ? B TRP 421 
247  1 Y 1 B THR 444 ? B THR 422 
248  1 Y 1 B THR 445 ? B THR 423 
249  1 Y 1 B PRO 446 ? B PRO 424 
250  1 Y 1 B ARG 447 ? B ARG 425 
251  1 Y 1 B GLU 448 ? B GLU 426 
252  1 Y 1 B SER 449 ? B SER 427 
253  1 Y 1 B VAL 450 ? B VAL 428 
254  1 Y 1 B LYS 451 ? B LYS 429 
255  1 Y 1 B LYS 452 ? B LYS 430 
256  1 Y 1 B TYR 453 ? B TYR 431 
257  1 Y 1 B ILE 454 ? B ILE 432 
258  1 Y 1 B LEU 455 ? B LEU 433 
259  1 Y 1 B GLU 456 ? B GLU 434 
260  1 Y 1 B TRP 457 ? B TRP 435 
261  1 Y 1 B CYS 458 ? B CYS 436 
262  1 Y 1 B VAL 459 ? B VAL 437 
263  1 Y 1 B LEU 460 ? B LEU 438 
264  1 Y 1 B SER 461 ? B SER 439 
265  1 Y 1 B ASP 462 ? B ASP 440 
266  1 Y 1 B LYS 463 ? B LYS 441 
267  1 Y 1 B ALA 464 ? B ALA 442 
268  1 Y 1 B PRO 465 ? B PRO 443 
269  1 Y 1 B CYS 466 ? B CYS 444 
270  1 Y 1 B ILE 467 ? B ILE 445 
271  1 Y 1 B THR 468 ? B THR 446 
272  1 Y 1 B ASP 469 ? B ASP 447 
273  1 Y 1 B TRP 470 ? B TRP 448 
274  1 Y 1 B GLN 471 ? B GLN 449 
275  1 Y 1 B GLN 472 ? B GLN 450 
276  1 Y 1 B GLU 473 ? B GLU 451 
277  1 Y 1 B ASP 474 ? B ASP 452 
278  1 Y 1 B GLY 475 ? B GLY 453 
279  1 Y 1 B THR 476 ? B THR 454 
280  1 Y 1 B VAL 477 ? B VAL 455 
281  1 Y 1 B HIS 478 ? B HIS 456 
282  1 Y 1 B ARG 479 ? B ARG 457 
283  1 Y 1 B THR 480 ? B THR 458 
284  1 Y 1 B TYR 481 ? B TYR 459 
285  1 Y 1 B LEU 482 ? B LEU 460 
286  1 Y 1 B ARG 483 ? B ARG 461 
287  1 Y 1 B GLY 484 ? B GLY 462 
288  1 Y 1 B ASN 485 ? B ASN 463 
289  1 Y 1 B LEU 486 ? B LEU 464 
290  1 Y 1 B ALA 487 ? B ALA 465 
291  1 Y 1 B GLU 488 ? B GLU 466 
292  1 Y 1 B SER 489 ? B SER 467 
293  1 Y 1 B LYS 490 ? B LYS 468 
294  1 Y 1 B CYS 491 ? B CYS 469 
295  1 Y 1 B TYR 492 ? B TYR 470 
296  1 Y 1 B LEU 493 ? B LEU 471 
297  1 Y 1 B ILE 494 ? B ILE 472 
298  1 Y 1 B THR 495 ? B THR 473 
299  1 Y 1 B VAL 496 ? B VAL 474 
300  1 Y 1 B THR 497 ? B THR 475 
301  1 Y 1 B PRO 498 ? B PRO 476 
302  1 Y 1 B VAL 499 ? B VAL 477 
303  1 Y 1 B TYR 500 ? B TYR 478 
304  1 Y 1 B ALA 501 ? B ALA 479 
305  1 Y 1 B ASP 502 ? B ASP 480 
306  1 Y 1 B GLY 503 ? B GLY 481 
307  1 Y 1 B PRO 504 ? B PRO 482 
308  1 Y 1 B GLY 505 ? B GLY 483 
309  1 Y 1 B SER 506 ? B SER 484 
310  1 Y 1 B PRO 507 ? B PRO 485 
311  1 Y 1 B GLU 508 ? B GLU 486 
312  1 Y 1 B SER 509 ? B SER 487 
313  1 Y 1 B ILE 510 ? B ILE 488 
314  1 Y 1 B LYS 511 ? B LYS 489 
315  1 Y 1 B ALA 512 ? B ALA 490 
316  1 Y 1 B TYR 513 ? B TYR 491 
317  1 Y 1 B LEU 514 ? B LEU 492 
318  1 Y 1 B LYS 515 ? B LYS 493 
319  1 Y 1 B GLN 516 ? B GLN 494 
320  1 Y 1 B ALA 517 ? B ALA 495 
321  1 Y 1 B PRO 518 ? B PRO 496 
322  1 Y 1 B PRO 519 ? B PRO 497 
323  1 Y 1 B SER 520 ? B SER 498 
324  1 Y 1 B LYS 521 ? B LYS 499 
325  1 Y 1 B GLY 522 ? B GLY 500 
326  1 Y 1 B PRO 523 ? B PRO 501 
327  1 Y 1 B THR 524 ? B THR 502 
328  1 Y 1 B VAL 525 ? B VAL 503 
329  1 Y 1 B ARG 526 ? B ARG 504 
330  1 Y 1 B THR 527 ? B THR 505 
331  1 Y 1 B LYS 528 ? B LYS 506 
332  1 Y 1 B LYS 529 ? B LYS 507 
333  1 Y 1 B VAL 530 ? B VAL 508 
334  1 Y 1 B GLY 531 ? B GLY 509 
335  1 Y 1 B LYS 532 ? B LYS 510 
336  1 Y 1 B ASN 533 ? B ASN 511 
337  1 Y 1 B GLU 534 ? B GLU 512 
338  1 Y 1 B ALA 535 ? B ALA 513 
339  1 Y 1 B VAL 536 ? B VAL 514 
340  1 Y 1 B LEU 537 ? B LEU 515 
341  1 Y 1 B GLU 538 ? B GLU 516 
342  1 Y 1 B TRP 539 ? B TRP 517 
343  1 Y 1 B ASP 540 ? B ASP 518 
344  1 Y 1 B GLN 541 ? B GLN 519 
345  1 Y 1 B LEU 542 ? B LEU 520 
346  1 Y 1 B PRO 543 ? B PRO 521 
347  1 Y 1 B VAL 544 ? B VAL 522 
348  1 Y 1 B ASP 545 ? B ASP 523 
349  1 Y 1 B VAL 546 ? B VAL 524 
350  1 Y 1 B GLN 547 ? B GLN 525 
351  1 Y 1 B ASN 548 ? B ASN 526 
352  1 Y 1 B GLY 549 ? B GLY 527 
353  1 Y 1 B PHE 550 ? B PHE 528 
354  1 Y 1 B ILE 551 ? B ILE 529 
355  1 Y 1 B ARG 552 ? B ARG 530 
356  1 Y 1 B ASN 553 ? B ASN 531 
357  1 Y 1 B TYR 554 ? B TYR 532 
358  1 Y 1 B THR 555 ? B THR 533 
359  1 Y 1 B ILE 556 ? B ILE 534 
360  1 Y 1 B PHE 557 ? B PHE 535 
361  1 Y 1 B TYR 558 ? B TYR 536 
362  1 Y 1 B ARG 559 ? B ARG 537 
363  1 Y 1 B THR 560 ? B THR 538 
364  1 Y 1 B ILE 561 ? B ILE 539 
365  1 Y 1 B ILE 562 ? B ILE 540 
366  1 Y 1 B GLY 563 ? B GLY 541 
367  1 Y 1 B ASN 564 ? B ASN 542 
368  1 Y 1 B GLU 565 ? B GLU 543 
369  1 Y 1 B THR 566 ? B THR 544 
370  1 Y 1 B ALA 567 ? B ALA 545 
371  1 Y 1 B VAL 568 ? B VAL 546 
372  1 Y 1 B ASN 569 ? B ASN 547 
373  1 Y 1 B VAL 570 ? B VAL 548 
374  1 Y 1 B ASP 571 ? B ASP 549 
375  1 Y 1 B SER 572 ? B SER 550 
376  1 Y 1 B SER 573 ? B SER 551 
377  1 Y 1 B HIS 574 ? B HIS 552 
378  1 Y 1 B THR 575 ? B THR 553 
379  1 Y 1 B GLU 576 ? B GLU 554 
380  1 Y 1 B TYR 577 ? B TYR 555 
381  1 Y 1 B THR 578 ? B THR 556 
382  1 Y 1 B LEU 579 ? B LEU 557 
383  1 Y 1 B SER 580 ? B SER 558 
384  1 Y 1 B SER 581 ? B SER 559 
385  1 Y 1 B LEU 582 ? B LEU 560 
386  1 Y 1 B THR 583 ? B THR 561 
387  1 Y 1 B SER 584 ? B SER 562 
388  1 Y 1 B ASP 585 ? B ASP 563 
389  1 Y 1 B THR 586 ? B THR 564 
390  1 Y 1 B LEU 587 ? B LEU 565 
391  1 Y 1 B TYR 588 ? B TYR 566 
392  1 Y 1 B MET 589 ? B MET 567 
393  1 Y 1 B VAL 590 ? B VAL 568 
394  1 Y 1 B ARG 591 ? B ARG 569 
395  1 Y 1 B MET 592 ? B MET 570 
396  1 Y 1 B ALA 593 ? B ALA 571 
397  1 Y 1 B ALA 594 ? B ALA 572 
398  1 Y 1 B TYR 595 ? B TYR 573 
399  1 Y 1 B THR 596 ? B THR 574 
400  1 Y 1 B ASP 597 ? B ASP 575 
401  1 Y 1 B GLU 598 ? B GLU 576 
402  1 Y 1 B GLY 599 ? B GLY 577 
403  1 Y 1 B GLY 600 ? B GLY 578 
404  1 Y 1 B LYS 601 ? B LYS 579 
405  1 Y 1 B ASP 602 ? B ASP 580 
406  1 Y 1 B GLY 603 ? B GLY 581 
407  1 Y 1 B PRO 604 ? B PRO 582 
408  1 Y 1 B GLU 605 ? B GLU 583 
409  1 Y 1 B PHE 606 ? B PHE 584 
410  1 Y 1 B THR 607 ? B THR 585 
411  1 Y 1 B PHE 608 ? B PHE 586 
412  1 Y 1 B THR 609 ? B THR 587 
413  1 Y 1 B THR 610 ? B THR 588 
414  1 Y 1 B PRO 611 ? B PRO 589 
415  1 Y 1 B LYS 612 ? B LYS 590 
416  1 Y 1 B PHE 613 ? B PHE 591 
417  1 Y 1 B ALA 614 ? B ALA 592 
418  1 Y 1 B GLN 615 ? B GLN 593 
419  1 Y 1 B GLY 616 ? B GLY 594 
420  1 Y 1 B GLU 617 ? B GLU 595 
421  1 Y 1 B ILE 618 ? B ILE 596 
422  1 Y 1 B GLU 619 ? B GLU 597 
423  1 Y 1 B GLU 620 ? B GLU 598 
424  1 Y 1 B GLN 621 ? B GLN 599 
425  1 Y 1 B LYS 622 ? B LYS 600 
426  1 Y 1 B LEU 623 ? B LEU 601 
427  1 Y 1 B ILE 624 ? B ILE 602 
428  1 Y 1 B SER 625 ? B SER 603 
429  1 Y 1 B GLU 626 ? B GLU 604 
430  1 Y 1 B GLU 627 ? B GLU 605 
431  1 Y 1 B ASP 628 ? B ASP 606 
432  1 Y 1 B LEU 629 ? B LEU 607 
433  1 Y 1 B GLY 630 ? B GLY 608 
434  1 Y 1 B GLY 631 ? B GLY 609 
435  1 Y 1 B GLU 632 ? B GLU 610 
436  1 Y 1 B GLN 633 ? B GLN 611 
437  1 Y 1 B LYS 634 ? B LYS 612 
438  1 Y 1 B LEU 635 ? B LEU 613 
439  1 Y 1 B ILE 636 ? B ILE 614 
440  1 Y 1 B SER 637 ? B SER 615 
441  1 Y 1 B GLU 638 ? B GLU 616 
442  1 Y 1 B GLU 639 ? B GLU 617 
443  1 Y 1 B ASP 640 ? B ASP 618 
444  1 Y 1 B LEU 641 ? B LEU 619 
445  1 Y 1 B HIS 642 ? B HIS 620 
446  1 Y 1 B HIS 643 ? B HIS 621 
447  1 Y 1 B HIS 644 ? B HIS 622 
448  1 Y 1 B HIS 645 ? B HIS 623 
449  1 Y 1 B HIS 646 ? B HIS 624 
450  1 Y 1 B HIS 647 ? B HIS 625 
451  1 Y 1 C GLN 45  ? C GLN 1   
452  1 Y 1 C LYS 46  ? C LYS 2   
453  1 Y 1 C LYS 47  ? C LYS 3   
454  1 Y 1 C GLY 48  ? C GLY 4   
455  1 Y 1 C ALA 49  ? C ALA 5   
456  1 Y 1 C PRO 50  ? C PRO 6   
457  1 Y 1 C HIS 51  ? C HIS 7   
458  1 Y 1 C ASP 52  ? C ASP 8   
459  1 Y 1 C LEU 53  ? C LEU 9   
460  1 Y 1 C LYS 54  ? C LYS 10  
461  1 Y 1 C CYS 55  ? C CYS 11  
462  1 Y 1 C VAL 56  ? C VAL 12  
463  1 Y 1 C THR 57  ? C THR 13  
464  1 Y 1 C ASN 58  ? C ASN 14  
465  1 Y 1 C ASN 59  ? C ASN 15  
466  1 Y 1 C LEU 60  ? C LEU 16  
467  1 Y 1 C GLN 61  ? C GLN 17  
468  1 Y 1 C VAL 62  ? C VAL 18  
469  1 Y 1 C TRP 63  ? C TRP 19  
470  1 Y 1 C ASN 64  ? C ASN 20  
471  1 Y 1 C CYS 65  ? C CYS 21  
472  1 Y 1 C SER 66  ? C SER 22  
473  1 Y 1 C TRP 67  ? C TRP 23  
474  1 Y 1 C LYS 68  ? C LYS 24  
475  1 Y 1 C ALA 69  ? C ALA 25  
476  1 Y 1 C PRO 70  ? C PRO 26  
477  1 Y 1 C SER 71  ? C SER 27  
478  1 Y 1 C GLY 72  ? C GLY 28  
479  1 Y 1 C THR 73  ? C THR 29  
480  1 Y 1 C GLY 74  ? C GLY 30  
481  1 Y 1 C ARG 75  ? C ARG 31  
482  1 Y 1 C GLY 76  ? C GLY 32  
483  1 Y 1 C THR 77  ? C THR 33  
484  1 Y 1 C ASP 78  ? C ASP 34  
485  1 Y 1 C TYR 79  ? C TYR 35  
486  1 Y 1 C GLU 80  ? C GLU 36  
487  1 Y 1 C VAL 81  ? C VAL 37  
488  1 Y 1 C CYS 82  ? C CYS 38  
489  1 Y 1 C ILE 83  ? C ILE 39  
490  1 Y 1 C GLU 84  ? C GLU 40  
491  1 Y 1 C ASN 85  ? C ASN 41  
492  1 Y 1 C ARG 86  ? C ARG 42  
493  1 Y 1 C SER 87  ? C SER 43  
494  1 Y 1 C ARG 88  ? C ARG 44  
495  1 Y 1 C SER 89  ? C SER 45  
496  1 Y 1 C CYS 90  ? C CYS 46  
497  1 Y 1 C TYR 91  ? C TYR 47  
498  1 Y 1 C GLN 92  ? C GLN 48  
499  1 Y 1 C LEU 93  ? C LEU 49  
500  1 Y 1 C GLU 94  ? C GLU 50  
501  1 Y 1 C LYS 95  ? C LYS 51  
502  1 Y 1 C THR 96  ? C THR 52  
503  1 Y 1 C SER 97  ? C SER 53  
504  1 Y 1 C ILE 98  ? C ILE 54  
505  1 Y 1 C LYS 99  ? C LYS 55  
506  1 Y 1 C ILE 100 ? C ILE 56  
507  1 Y 1 C PRO 101 ? C PRO 57  
508  1 Y 1 C ALA 102 ? C ALA 58  
509  1 Y 1 C LEU 103 ? C LEU 59  
510  1 Y 1 C SER 104 ? C SER 60  
511  1 Y 1 C HIS 105 ? C HIS 61  
512  1 Y 1 C GLY 106 ? C GLY 62  
513  1 Y 1 C ASP 107 ? C ASP 63  
514  1 Y 1 C TYR 108 ? C TYR 64  
515  1 Y 1 C GLU 109 ? C GLU 65  
516  1 Y 1 C ILE 110 ? C ILE 66  
517  1 Y 1 C THR 111 ? C THR 67  
518  1 Y 1 C ILE 112 ? C ILE 68  
519  1 Y 1 C ASN 113 ? C ASN 69  
520  1 Y 1 C SER 114 ? C SER 70  
521  1 Y 1 C LEU 115 ? C LEU 71  
522  1 Y 1 C HIS 116 ? C HIS 72  
523  1 Y 1 C ASP 117 ? C ASP 73  
524  1 Y 1 C PHE 118 ? C PHE 74  
525  1 Y 1 C GLY 119 ? C GLY 75  
526  1 Y 1 C SER 120 ? C SER 76  
527  1 Y 1 C SER 121 ? C SER 77  
528  1 Y 1 C THR 122 ? C THR 78  
529  1 Y 1 C SER 123 ? C SER 79  
530  1 Y 1 C LYS 124 ? C LYS 80  
531  1 Y 1 C PHE 125 ? C PHE 81  
532  1 Y 1 C THR 126 ? C THR 82  
533  1 Y 1 C LEU 127 ? C LEU 83  
534  1 Y 1 C ASN 128 ? C ASN 84  
535  1 Y 1 C GLU 129 ? C GLU 85  
536  1 Y 1 C GLN 130 ? C GLN 86  
537  1 Y 1 C ASN 131 ? C ASN 87  
538  1 Y 1 C VAL 132 ? C VAL 88  
539  1 Y 1 C SER 133 ? C SER 89  
540  1 Y 1 C LEU 134 ? C LEU 90  
541  1 Y 1 C ILE 135 ? C ILE 91  
542  1 Y 1 C PRO 136 ? C PRO 92  
543  1 Y 1 C ASP 137 ? C ASP 93  
544  1 Y 1 C THR 138 ? C THR 94  
545  1 Y 1 C PRO 139 ? C PRO 95  
546  1 Y 1 C GLU 140 ? C GLU 96  
547  1 Y 1 C ILE 141 ? C ILE 97  
548  1 Y 1 C LEU 142 ? C LEU 98  
549  1 Y 1 C ASN 143 ? C ASN 99  
550  1 Y 1 C LEU 144 ? C LEU 100 
551  1 Y 1 C SER 145 ? C SER 101 
552  1 Y 1 C ALA 146 ? C ALA 102 
553  1 Y 1 C ASP 147 ? C ASP 103 
554  1 Y 1 C PHE 148 ? C PHE 104 
555  1 Y 1 C SER 149 ? C SER 105 
556  1 Y 1 C THR 150 ? C THR 106 
557  1 Y 1 C SER 151 ? C SER 107 
558  1 Y 1 C THR 152 ? C THR 108 
559  1 Y 1 C LEU 153 ? C LEU 109 
560  1 Y 1 C TYR 154 ? C TYR 110 
561  1 Y 1 C LEU 155 ? C LEU 111 
562  1 Y 1 C LYS 156 ? C LYS 112 
563  1 Y 1 C TRP 157 ? C TRP 113 
564  1 Y 1 C ASN 158 ? C ASN 114 
565  1 Y 1 C ASP 159 ? C ASP 115 
566  1 Y 1 C ARG 160 ? C ARG 116 
567  1 Y 1 C GLY 161 ? C GLY 117 
568  1 Y 1 C SER 162 ? C SER 118 
569  1 Y 1 C VAL 163 ? C VAL 119 
570  1 Y 1 C PHE 164 ? C PHE 120 
571  1 Y 1 C PRO 165 ? C PRO 121 
572  1 Y 1 C HIS 166 ? C HIS 122 
573  1 Y 1 C ARG 167 ? C ARG 123 
574  1 Y 1 C SER 168 ? C SER 124 
575  1 Y 1 C ASN 169 ? C ASN 125 
576  1 Y 1 C VAL 170 ? C VAL 126 
577  1 Y 1 C ILE 171 ? C ILE 127 
578  1 Y 1 C TRP 172 ? C TRP 128 
579  1 Y 1 C GLU 173 ? C GLU 129 
580  1 Y 1 C ILE 174 ? C ILE 130 
581  1 Y 1 C LYS 175 ? C LYS 131 
582  1 Y 1 C VAL 176 ? C VAL 132 
583  1 Y 1 C LEU 177 ? C LEU 133 
584  1 Y 1 C ARG 178 ? C ARG 134 
585  1 Y 1 C LYS 179 ? C LYS 135 
586  1 Y 1 C GLU 180 ? C GLU 136 
587  1 Y 1 C SER 181 ? C SER 137 
588  1 Y 1 C MET 182 ? C MET 138 
589  1 Y 1 C GLU 183 ? C GLU 139 
590  1 Y 1 C LEU 184 ? C LEU 140 
591  1 Y 1 C VAL 185 ? C VAL 141 
592  1 Y 1 C LYS 186 ? C LYS 142 
593  1 Y 1 C LEU 187 ? C LEU 143 
594  1 Y 1 C VAL 188 ? C VAL 144 
595  1 Y 1 C THR 189 ? C THR 145 
596  1 Y 1 C HIS 190 ? C HIS 146 
597  1 Y 1 C ASN 191 ? C ASN 147 
598  1 Y 1 C THR 192 ? C THR 148 
599  1 Y 1 C THR 193 ? C THR 149 
600  1 Y 1 C LEU 194 ? C LEU 150 
601  1 Y 1 C ASN 195 ? C ASN 151 
602  1 Y 1 C GLY 196 ? C GLY 152 
603  1 Y 1 C LYS 197 ? C LYS 153 
604  1 Y 1 C ASP 198 ? C ASP 154 
605  1 Y 1 C THR 199 ? C THR 155 
606  1 Y 1 C LEU 200 ? C LEU 156 
607  1 Y 1 C HIS 201 ? C HIS 157 
608  1 Y 1 C HIS 202 ? C HIS 158 
609  1 Y 1 C TRP 203 ? C TRP 159 
610  1 Y 1 C SER 204 ? C SER 160 
611  1 Y 1 C TRP 205 ? C TRP 161 
612  1 Y 1 C ALA 206 ? C ALA 162 
613  1 Y 1 C SER 207 ? C SER 163 
614  1 Y 1 C ASP 208 ? C ASP 164 
615  1 Y 1 C MET 209 ? C MET 165 
616  1 Y 1 C PRO 210 ? C PRO 166 
617  1 Y 1 C LEU 211 ? C LEU 167 
618  1 Y 1 C GLU 212 ? C GLU 168 
619  1 Y 1 C CYS 213 ? C CYS 169 
620  1 Y 1 C ALA 214 ? C ALA 170 
621  1 Y 1 C ILE 215 ? C ILE 171 
622  1 Y 1 C HIS 216 ? C HIS 172 
623  1 Y 1 C PHE 217 ? C PHE 173 
624  1 Y 1 C VAL 218 ? C VAL 174 
625  1 Y 1 C GLU 219 ? C GLU 175 
626  1 Y 1 C ILE 220 ? C ILE 176 
627  1 Y 1 C ARG 221 ? C ARG 177 
628  1 Y 1 C CYS 222 ? C CYS 178 
629  1 Y 1 C TYR 223 ? C TYR 179 
630  1 Y 1 C ILE 224 ? C ILE 180 
631  1 Y 1 C ASP 225 ? C ASP 181 
632  1 Y 1 C ASN 226 ? C ASN 182 
633  1 Y 1 C LEU 227 ? C LEU 183 
634  1 Y 1 C HIS 228 ? C HIS 184 
635  1 Y 1 C PHE 229 ? C PHE 185 
636  1 Y 1 C SER 230 ? C SER 186 
637  1 Y 1 C GLY 231 ? C GLY 187 
638  1 Y 1 C LEU 232 ? C LEU 188 
639  1 Y 1 C GLU 233 ? C GLU 189 
640  1 Y 1 C GLU 234 ? C GLU 190 
641  1 Y 1 C TRP 235 ? C TRP 191 
642  1 Y 1 C SER 236 ? C SER 192 
643  1 Y 1 C ASP 237 ? C ASP 193 
644  1 Y 1 C TRP 238 ? C TRP 194 
645  1 Y 1 C SER 239 ? C SER 195 
646  1 Y 1 C PRO 240 ? C PRO 196 
647  1 Y 1 C VAL 241 ? C VAL 197 
648  1 Y 1 C LYS 242 ? C LYS 198 
649  1 Y 1 C ASN 243 ? C ASN 199 
650  1 Y 1 C ILE 244 ? C ILE 200 
651  1 Y 1 C SER 245 ? C SER 201 
652  1 Y 1 C TRP 246 ? C TRP 202 
653  1 Y 1 C ILE 247 ? C ILE 203 
654  1 Y 1 C PRO 248 ? C PRO 204 
655  1 Y 1 C ASP 249 ? C ASP 205 
656  1 Y 1 C SER 250 ? C SER 206 
657  1 Y 1 C GLN 251 ? C GLN 207 
658  1 Y 1 C TYR 432 ? C TYR 388 
659  1 Y 1 C PRO 433 ? C PRO 389 
660  1 Y 1 C HIS 434 ? C HIS 390 
661  1 Y 1 C THR 435 ? C THR 391 
662  1 Y 1 C PRO 436 ? C PRO 392 
663  1 Y 1 C THR 437 ? C THR 393 
664  1 Y 1 C SER 438 ? C SER 394 
665  1 Y 1 C PHE 439 ? C PHE 395 
666  1 Y 1 C LYS 440 ? C LYS 396 
667  1 Y 1 C VAL 441 ? C VAL 397 
668  1 Y 1 C LYS 442 ? C LYS 398 
669  1 Y 1 C ASP 443 ? C ASP 399 
670  1 Y 1 C ILE 444 ? C ILE 400 
671  1 Y 1 C ASN 445 ? C ASN 401 
672  1 Y 1 C SER 446 ? C SER 402 
673  1 Y 1 C THR 447 ? C THR 403 
674  1 Y 1 C ALA 448 ? C ALA 404 
675  1 Y 1 C VAL 449 ? C VAL 405 
676  1 Y 1 C LYS 450 ? C LYS 406 
677  1 Y 1 C LEU 451 ? C LEU 407 
678  1 Y 1 C SER 452 ? C SER 408 
679  1 Y 1 C TRP 453 ? C TRP 409 
680  1 Y 1 C HIS 454 ? C HIS 410 
681  1 Y 1 C LEU 455 ? C LEU 411 
682  1 Y 1 C PRO 456 ? C PRO 412 
683  1 Y 1 C GLY 457 ? C GLY 413 
684  1 Y 1 C ASN 458 ? C ASN 414 
685  1 Y 1 C PHE 459 ? C PHE 415 
686  1 Y 1 C ALA 460 ? C ALA 416 
687  1 Y 1 C LYS 461 ? C LYS 417 
688  1 Y 1 C ILE 462 ? C ILE 418 
689  1 Y 1 C ASN 463 ? C ASN 419 
690  1 Y 1 C PHE 464 ? C PHE 420 
691  1 Y 1 C LEU 465 ? C LEU 421 
692  1 Y 1 C CYS 466 ? C CYS 422 
693  1 Y 1 C GLU 467 ? C GLU 423 
694  1 Y 1 C ILE 468 ? C ILE 424 
695  1 Y 1 C GLU 469 ? C GLU 425 
696  1 Y 1 C ILE 470 ? C ILE 426 
697  1 Y 1 C LYS 471 ? C LYS 427 
698  1 Y 1 C LYS 472 ? C LYS 428 
699  1 Y 1 C SER 473 ? C SER 429 
700  1 Y 1 C ASN 474 ? C ASN 430 
701  1 Y 1 C SER 475 ? C SER 431 
702  1 Y 1 C VAL 476 ? C VAL 432 
703  1 Y 1 C GLN 477 ? C GLN 433 
704  1 Y 1 C GLU 478 ? C GLU 434 
705  1 Y 1 C GLN 479 ? C GLN 435 
706  1 Y 1 C ARG 480 ? C ARG 436 
707  1 Y 1 C ASN 481 ? C ASN 437 
708  1 Y 1 C VAL 482 ? C VAL 438 
709  1 Y 1 C THR 483 ? C THR 439 
710  1 Y 1 C ILE 484 ? C ILE 440 
711  1 Y 1 C LYS 485 ? C LYS 441 
712  1 Y 1 C GLY 486 ? C GLY 442 
713  1 Y 1 C VAL 487 ? C VAL 443 
714  1 Y 1 C GLU 488 ? C GLU 444 
715  1 Y 1 C ASN 489 ? C ASN 445 
716  1 Y 1 C SER 490 ? C SER 446 
717  1 Y 1 C SER 491 ? C SER 447 
718  1 Y 1 C TYR 492 ? C TYR 448 
719  1 Y 1 C LEU 493 ? C LEU 449 
720  1 Y 1 C VAL 494 ? C VAL 450 
721  1 Y 1 C ALA 495 ? C ALA 451 
722  1 Y 1 C LEU 496 ? C LEU 452 
723  1 Y 1 C ASP 497 ? C ASP 453 
724  1 Y 1 C LYS 498 ? C LYS 454 
725  1 Y 1 C LEU 499 ? C LEU 455 
726  1 Y 1 C ASN 500 ? C ASN 456 
727  1 Y 1 C PRO 501 ? C PRO 457 
728  1 Y 1 C TYR 502 ? C TYR 458 
729  1 Y 1 C THR 503 ? C THR 459 
730  1 Y 1 C LEU 504 ? C LEU 460 
731  1 Y 1 C TYR 505 ? C TYR 461 
732  1 Y 1 C THR 506 ? C THR 462 
733  1 Y 1 C PHE 507 ? C PHE 463 
734  1 Y 1 C ARG 508 ? C ARG 464 
735  1 Y 1 C ILE 509 ? C ILE 465 
736  1 Y 1 C ARG 510 ? C ARG 466 
737  1 Y 1 C CYS 511 ? C CYS 467 
738  1 Y 1 C SER 512 ? C SER 468 
739  1 Y 1 C THR 513 ? C THR 469 
740  1 Y 1 C GLU 514 ? C GLU 470 
741  1 Y 1 C THR 515 ? C THR 471 
742  1 Y 1 C PHE 516 ? C PHE 472 
743  1 Y 1 C TRP 517 ? C TRP 473 
744  1 Y 1 C LYS 518 ? C LYS 474 
745  1 Y 1 C TRP 519 ? C TRP 475 
746  1 Y 1 C SER 520 ? C SER 476 
747  1 Y 1 C LYS 521 ? C LYS 477 
748  1 Y 1 C TRP 522 ? C TRP 478 
749  1 Y 1 C SER 523 ? C SER 479 
750  1 Y 1 C ASN 524 ? C ASN 480 
751  1 Y 1 C LYS 525 ? C LYS 481 
752  1 Y 1 C LYS 526 ? C LYS 482 
753  1 Y 1 C GLN 527 ? C GLN 483 
754  1 Y 1 C HIS 528 ? C HIS 484 
755  1 Y 1 C LEU 529 ? C LEU 485 
756  1 Y 1 C THR 530 ? C THR 486 
757  1 Y 1 C THR 531 ? C THR 487 
758  1 Y 1 C GLU 532 ? C GLU 488 
759  1 Y 1 C ALA 533 ? C ALA 489 
760  1 Y 1 C SER 534 ? C SER 490 
761  1 Y 1 C PRO 535 ? C PRO 491 
762  1 Y 1 C SER 536 ? C SER 492 
763  1 Y 1 C LYS 537 ? C LYS 493 
764  1 Y 1 C GLY 538 ? C GLY 494 
765  1 Y 1 C PRO 539 ? C PRO 495 
766  1 Y 1 C ASP 540 ? C ASP 496 
767  1 Y 1 C THR 541 ? C THR 497 
768  1 Y 1 C TRP 542 ? C TRP 498 
769  1 Y 1 C ARG 543 ? C ARG 499 
770  1 Y 1 C GLU 544 ? C GLU 500 
771  1 Y 1 C TRP 545 ? C TRP 501 
772  1 Y 1 C SER 546 ? C SER 502 
773  1 Y 1 C SER 547 ? C SER 503 
774  1 Y 1 C ASP 548 ? C ASP 504 
775  1 Y 1 C GLY 549 ? C GLY 505 
776  1 Y 1 C LYS 550 ? C LYS 506 
777  1 Y 1 C ASN 551 ? C ASN 507 
778  1 Y 1 C LEU 552 ? C LEU 508 
779  1 Y 1 C ILE 553 ? C ILE 509 
780  1 Y 1 C ILE 554 ? C ILE 510 
781  1 Y 1 C TYR 555 ? C TYR 511 
782  1 Y 1 C TRP 556 ? C TRP 512 
783  1 Y 1 C LYS 557 ? C LYS 513 
784  1 Y 1 C PRO 558 ? C PRO 514 
785  1 Y 1 C LEU 559 ? C LEU 515 
786  1 Y 1 C PRO 560 ? C PRO 516 
787  1 Y 1 C ILE 561 ? C ILE 517 
788  1 Y 1 C ASN 562 ? C ASN 518 
789  1 Y 1 C GLU 563 ? C GLU 519 
790  1 Y 1 C ALA 564 ? C ALA 520 
791  1 Y 1 C ASN 565 ? C ASN 521 
792  1 Y 1 C GLY 566 ? C GLY 522 
793  1 Y 1 C LYS 567 ? C LYS 523 
794  1 Y 1 C ILE 568 ? C ILE 524 
795  1 Y 1 C LEU 569 ? C LEU 525 
796  1 Y 1 C SER 570 ? C SER 526 
797  1 Y 1 C TYR 571 ? C TYR 527 
798  1 Y 1 C ASN 572 ? C ASN 528 
799  1 Y 1 C VAL 573 ? C VAL 529 
800  1 Y 1 C SER 574 ? C SER 530 
801  1 Y 1 C CYS 575 ? C CYS 531 
802  1 Y 1 C SER 576 ? C SER 532 
803  1 Y 1 C SER 577 ? C SER 533 
804  1 Y 1 C ASP 578 ? C ASP 534 
805  1 Y 1 C GLU 579 ? C GLU 535 
806  1 Y 1 C GLU 580 ? C GLU 536 
807  1 Y 1 C THR 581 ? C THR 537 
808  1 Y 1 C GLN 582 ? C GLN 538 
809  1 Y 1 C SER 583 ? C SER 539 
810  1 Y 1 C LEU 584 ? C LEU 540 
811  1 Y 1 C SER 585 ? C SER 541 
812  1 Y 1 C GLU 586 ? C GLU 542 
813  1 Y 1 C ILE 587 ? C ILE 543 
814  1 Y 1 C PRO 588 ? C PRO 544 
815  1 Y 1 C ASP 589 ? C ASP 545 
816  1 Y 1 C PRO 590 ? C PRO 546 
817  1 Y 1 C GLN 591 ? C GLN 547 
818  1 Y 1 C HIS 592 ? C HIS 548 
819  1 Y 1 C LYS 593 ? C LYS 549 
820  1 Y 1 C ALA 594 ? C ALA 550 
821  1 Y 1 C GLU 595 ? C GLU 551 
822  1 Y 1 C ILE 596 ? C ILE 552 
823  1 Y 1 C ARG 597 ? C ARG 553 
824  1 Y 1 C LEU 598 ? C LEU 554 
825  1 Y 1 C ASP 599 ? C ASP 555 
826  1 Y 1 C LYS 600 ? C LYS 556 
827  1 Y 1 C ASN 601 ? C ASN 557 
828  1 Y 1 C ASP 602 ? C ASP 558 
829  1 Y 1 C TYR 603 ? C TYR 559 
830  1 Y 1 C ILE 604 ? C ILE 560 
831  1 Y 1 C ILE 605 ? C ILE 561 
832  1 Y 1 C SER 606 ? C SER 562 
833  1 Y 1 C VAL 607 ? C VAL 563 
834  1 Y 1 C VAL 608 ? C VAL 564 
835  1 Y 1 C ALA 609 ? C ALA 565 
836  1 Y 1 C LYS 610 ? C LYS 566 
837  1 Y 1 C ASN 611 ? C ASN 567 
838  1 Y 1 C SER 612 ? C SER 568 
839  1 Y 1 C VAL 613 ? C VAL 569 
840  1 Y 1 C GLY 614 ? C GLY 570 
841  1 Y 1 C SER 615 ? C SER 571 
842  1 Y 1 C SER 616 ? C SER 572 
843  1 Y 1 C PRO 617 ? C PRO 573 
844  1 Y 1 C PRO 618 ? C PRO 574 
845  1 Y 1 C SER 619 ? C SER 575 
846  1 Y 1 C LYS 620 ? C LYS 576 
847  1 Y 1 C ILE 621 ? C ILE 577 
848  1 Y 1 C ALA 622 ? C ALA 578 
849  1 Y 1 C SER 623 ? C SER 579 
850  1 Y 1 C MET 624 ? C MET 580 
851  1 Y 1 C GLU 625 ? C GLU 581 
852  1 Y 1 C ILE 626 ? C ILE 582 
853  1 Y 1 C PRO 627 ? C PRO 583 
854  1 Y 1 C ASN 628 ? C ASN 584 
855  1 Y 1 C ASP 629 ? C ASP 585 
856  1 Y 1 C ASP 630 ? C ASP 586 
857  1 Y 1 C LEU 631 ? C LEU 587 
858  1 Y 1 C LYS 632 ? C LYS 588 
859  1 Y 1 C ILE 633 ? C ILE 589 
860  1 Y 1 C GLU 634 ? C GLU 590 
861  1 Y 1 C GLN 635 ? C GLN 591 
862  1 Y 1 C VAL 636 ? C VAL 592 
863  1 Y 1 C VAL 637 ? C VAL 593 
864  1 Y 1 C GLY 638 ? C GLY 594 
865  1 Y 1 C MET 639 ? C MET 595 
866  1 Y 1 C GLY 640 ? C GLY 596 
867  1 Y 1 C LYS 641 ? C LYS 597 
868  1 Y 1 C GLY 642 ? C GLY 598 
869  1 Y 1 C ILE 643 ? C ILE 599 
870  1 Y 1 C LEU 644 ? C LEU 600 
871  1 Y 1 C LEU 645 ? C LEU 601 
872  1 Y 1 C THR 646 ? C THR 602 
873  1 Y 1 C TRP 647 ? C TRP 603 
874  1 Y 1 C HIS 648 ? C HIS 604 
875  1 Y 1 C TYR 649 ? C TYR 605 
876  1 Y 1 C ASP 650 ? C ASP 606 
877  1 Y 1 C PRO 651 ? C PRO 607 
878  1 Y 1 C ASN 652 ? C ASN 608 
879  1 Y 1 C MET 653 ? C MET 609 
880  1 Y 1 C THR 654 ? C THR 610 
881  1 Y 1 C CYS 655 ? C CYS 611 
882  1 Y 1 C ASP 656 ? C ASP 612 
883  1 Y 1 C TYR 657 ? C TYR 613 
884  1 Y 1 C VAL 658 ? C VAL 614 
885  1 Y 1 C ILE 659 ? C ILE 615 
886  1 Y 1 C LYS 660 ? C LYS 616 
887  1 Y 1 C TRP 661 ? C TRP 617 
888  1 Y 1 C CYS 662 ? C CYS 618 
889  1 Y 1 C ASN 663 ? C ASN 619 
890  1 Y 1 C SER 664 ? C SER 620 
891  1 Y 1 C SER 665 ? C SER 621 
892  1 Y 1 C ARG 666 ? C ARG 622 
893  1 Y 1 C SER 667 ? C SER 623 
894  1 Y 1 C GLU 668 ? C GLU 624 
895  1 Y 1 C PRO 669 ? C PRO 625 
896  1 Y 1 C CYS 670 ? C CYS 626 
897  1 Y 1 C LEU 671 ? C LEU 627 
898  1 Y 1 C MET 672 ? C MET 628 
899  1 Y 1 C ASP 673 ? C ASP 629 
900  1 Y 1 C TRP 674 ? C TRP 630 
901  1 Y 1 C ARG 675 ? C ARG 631 
902  1 Y 1 C LYS 676 ? C LYS 632 
903  1 Y 1 C VAL 677 ? C VAL 633 
904  1 Y 1 C PRO 678 ? C PRO 634 
905  1 Y 1 C SER 679 ? C SER 635 
906  1 Y 1 C ASN 680 ? C ASN 636 
907  1 Y 1 C SER 681 ? C SER 637 
908  1 Y 1 C THR 682 ? C THR 638 
909  1 Y 1 C GLU 683 ? C GLU 639 
910  1 Y 1 C THR 684 ? C THR 640 
911  1 Y 1 C VAL 685 ? C VAL 641 
912  1 Y 1 C ILE 686 ? C ILE 642 
913  1 Y 1 C GLU 687 ? C GLU 643 
914  1 Y 1 C SER 688 ? C SER 644 
915  1 Y 1 C ASP 689 ? C ASP 645 
916  1 Y 1 C GLU 690 ? C GLU 646 
917  1 Y 1 C PHE 691 ? C PHE 647 
918  1 Y 1 C ARG 692 ? C ARG 648 
919  1 Y 1 C PRO 693 ? C PRO 649 
920  1 Y 1 C GLY 694 ? C GLY 650 
921  1 Y 1 C ILE 695 ? C ILE 651 
922  1 Y 1 C ARG 696 ? C ARG 652 
923  1 Y 1 C TYR 697 ? C TYR 653 
924  1 Y 1 C ASN 698 ? C ASN 654 
925  1 Y 1 C PHE 699 ? C PHE 655 
926  1 Y 1 C PHE 700 ? C PHE 656 
927  1 Y 1 C LEU 701 ? C LEU 657 
928  1 Y 1 C TYR 702 ? C TYR 658 
929  1 Y 1 C GLY 703 ? C GLY 659 
930  1 Y 1 C CYS 704 ? C CYS 660 
931  1 Y 1 C ARG 705 ? C ARG 661 
932  1 Y 1 C ASN 706 ? C ASN 662 
933  1 Y 1 C GLN 707 ? C GLN 663 
934  1 Y 1 C GLY 708 ? C GLY 664 
935  1 Y 1 C TYR 709 ? C TYR 665 
936  1 Y 1 C GLN 710 ? C GLN 666 
937  1 Y 1 C LEU 711 ? C LEU 667 
938  1 Y 1 C LEU 712 ? C LEU 668 
939  1 Y 1 C ARG 713 ? C ARG 669 
940  1 Y 1 C SER 714 ? C SER 670 
941  1 Y 1 C MET 715 ? C MET 671 
942  1 Y 1 C ILE 716 ? C ILE 672 
943  1 Y 1 C GLY 717 ? C GLY 673 
944  1 Y 1 C TYR 718 ? C TYR 674 
945  1 Y 1 C ILE 719 ? C ILE 675 
946  1 Y 1 C GLU 720 ? C GLU 676 
947  1 Y 1 C GLU 721 ? C GLU 677 
948  1 Y 1 C LEU 722 ? C LEU 678 
949  1 Y 1 C ALA 723 ? C ALA 679 
950  1 Y 1 C PRO 724 ? C PRO 680 
951  1 Y 1 C ILE 725 ? C ILE 681 
952  1 Y 1 C VAL 726 ? C VAL 682 
953  1 Y 1 C ALA 727 ? C ALA 683 
954  1 Y 1 C PRO 728 ? C PRO 684 
955  1 Y 1 C ASN 729 ? C ASN 685 
956  1 Y 1 C PHE 730 ? C PHE 686 
957  1 Y 1 C THR 731 ? C THR 687 
958  1 Y 1 C VAL 732 ? C VAL 688 
959  1 Y 1 C GLU 733 ? C GLU 689 
960  1 Y 1 C ASP 734 ? C ASP 690 
961  1 Y 1 C THR 735 ? C THR 691 
962  1 Y 1 C SER 736 ? C SER 692 
963  1 Y 1 C ALA 737 ? C ALA 693 
964  1 Y 1 C ASP 738 ? C ASP 694 
965  1 Y 1 C SER 739 ? C SER 695 
966  1 Y 1 C ILE 740 ? C ILE 696 
967  1 Y 1 C LEU 741 ? C LEU 697 
968  1 Y 1 C VAL 742 ? C VAL 698 
969  1 Y 1 C LYS 743 ? C LYS 699 
970  1 Y 1 C TRP 744 ? C TRP 700 
971  1 Y 1 C GLU 745 ? C GLU 701 
972  1 Y 1 C ASP 746 ? C ASP 702 
973  1 Y 1 C ILE 747 ? C ILE 703 
974  1 Y 1 C PRO 748 ? C PRO 704 
975  1 Y 1 C VAL 749 ? C VAL 705 
976  1 Y 1 C GLU 750 ? C GLU 706 
977  1 Y 1 C GLU 751 ? C GLU 707 
978  1 Y 1 C LEU 752 ? C LEU 708 
979  1 Y 1 C ARG 753 ? C ARG 709 
980  1 Y 1 C GLY 754 ? C GLY 710 
981  1 Y 1 C PHE 755 ? C PHE 711 
982  1 Y 1 C LEU 756 ? C LEU 712 
983  1 Y 1 C ARG 757 ? C ARG 713 
984  1 Y 1 C GLY 758 ? C GLY 714 
985  1 Y 1 C TYR 759 ? C TYR 715 
986  1 Y 1 C LEU 760 ? C LEU 716 
987  1 Y 1 C PHE 761 ? C PHE 717 
988  1 Y 1 C TYR 762 ? C TYR 718 
989  1 Y 1 C PHE 763 ? C PHE 719 
990  1 Y 1 C GLY 764 ? C GLY 720 
991  1 Y 1 C LYS 765 ? C LYS 721 
992  1 Y 1 C GLY 766 ? C GLY 722 
993  1 Y 1 C GLU 767 ? C GLU 723 
994  1 Y 1 C ARG 768 ? C ARG 724 
995  1 Y 1 C ASP 769 ? C ASP 725 
996  1 Y 1 C THR 770 ? C THR 726 
997  1 Y 1 C SER 771 ? C SER 727 
998  1 Y 1 C LYS 772 ? C LYS 728 
999  1 Y 1 C MET 773 ? C MET 729 
1000 1 Y 1 C ARG 774 ? C ARG 730 
1001 1 Y 1 C VAL 775 ? C VAL 731 
1002 1 Y 1 C LEU 776 ? C LEU 732 
1003 1 Y 1 C GLU 777 ? C GLU 733 
1004 1 Y 1 C SER 778 ? C SER 734 
1005 1 Y 1 C GLY 779 ? C GLY 735 
1006 1 Y 1 C ARG 780 ? C ARG 736 
1007 1 Y 1 C SER 781 ? C SER 737 
1008 1 Y 1 C ASP 782 ? C ASP 738 
1009 1 Y 1 C ILE 783 ? C ILE 739 
1010 1 Y 1 C LYS 784 ? C LYS 740 
1011 1 Y 1 C VAL 785 ? C VAL 741 
1012 1 Y 1 C LYS 786 ? C LYS 742 
1013 1 Y 1 C ASN 787 ? C ASN 743 
1014 1 Y 1 C ILE 788 ? C ILE 744 
1015 1 Y 1 C THR 789 ? C THR 745 
1016 1 Y 1 C ASP 790 ? C ASP 746 
1017 1 Y 1 C ILE 791 ? C ILE 747 
1018 1 Y 1 C SER 792 ? C SER 748 
1019 1 Y 1 C GLN 793 ? C GLN 749 
1020 1 Y 1 C LYS 794 ? C LYS 750 
1021 1 Y 1 C THR 795 ? C THR 751 
1022 1 Y 1 C LEU 796 ? C LEU 752 
1023 1 Y 1 C ARG 797 ? C ARG 753 
1024 1 Y 1 C ILE 798 ? C ILE 754 
1025 1 Y 1 C ALA 799 ? C ALA 755 
1026 1 Y 1 C ASP 800 ? C ASP 756 
1027 1 Y 1 C LEU 801 ? C LEU 757 
1028 1 Y 1 C GLN 802 ? C GLN 758 
1029 1 Y 1 C GLY 803 ? C GLY 759 
1030 1 Y 1 C LYS 804 ? C LYS 760 
1031 1 Y 1 C THR 805 ? C THR 761 
1032 1 Y 1 C SER 806 ? C SER 762 
1033 1 Y 1 C TYR 807 ? C TYR 763 
1034 1 Y 1 C HIS 808 ? C HIS 764 
1035 1 Y 1 C LEU 809 ? C LEU 765 
1036 1 Y 1 C VAL 810 ? C VAL 766 
1037 1 Y 1 C LEU 811 ? C LEU 767 
1038 1 Y 1 C ARG 812 ? C ARG 768 
1039 1 Y 1 C ALA 813 ? C ALA 769 
1040 1 Y 1 C TYR 814 ? C TYR 770 
1041 1 Y 1 C THR 815 ? C THR 771 
1042 1 Y 1 C ASP 816 ? C ASP 772 
1043 1 Y 1 C GLY 817 ? C GLY 773 
1044 1 Y 1 C GLY 818 ? C GLY 774 
1045 1 Y 1 C VAL 819 ? C VAL 775 
1046 1 Y 1 C GLY 820 ? C GLY 776 
1047 1 Y 1 C PRO 821 ? C PRO 777 
1048 1 Y 1 C GLU 822 ? C GLU 778 
1049 1 Y 1 C LYS 823 ? C LYS 779 
1050 1 Y 1 C SER 824 ? C SER 780 
1051 1 Y 1 C MET 825 ? C MET 781 
1052 1 Y 1 C TYR 826 ? C TYR 782 
1053 1 Y 1 C VAL 827 ? C VAL 783 
1054 1 Y 1 C VAL 828 ? C VAL 784 
1055 1 Y 1 C THR 829 ? C THR 785 
1056 1 Y 1 C LYS 830 ? C LYS 786 
1057 1 Y 1 C GLU 831 ? C GLU 787 
1058 1 Y 1 C ASN 832 ? C ASN 788 
1059 1 Y 1 C SER 833 ? C SER 789 
1060 1 Y 1 C GLU 834 ? C GLU 790 
1061 1 Y 1 C GLN 835 ? C GLN 791 
1062 1 Y 1 C LYS 836 ? C LYS 792 
1063 1 Y 1 C LEU 837 ? C LEU 793 
1064 1 Y 1 C ILE 838 ? C ILE 794 
1065 1 Y 1 C SER 839 ? C SER 795 
1066 1 Y 1 C GLU 840 ? C GLU 796 
1067 1 Y 1 C GLU 841 ? C GLU 797 
1068 1 Y 1 C ASP 842 ? C ASP 798 
1069 1 Y 1 C LEU 843 ? C LEU 799 
1070 1 Y 1 C GLY 844 ? C GLY 800 
1071 1 Y 1 C GLY 845 ? C GLY 801 
1072 1 Y 1 C GLU 846 ? C GLU 802 
1073 1 Y 1 C GLN 847 ? C GLN 803 
1074 1 Y 1 C LYS 848 ? C LYS 804 
1075 1 Y 1 C LEU 849 ? C LEU 805 
1076 1 Y 1 C ILE 850 ? C ILE 806 
1077 1 Y 1 C SER 851 ? C SER 807 
1078 1 Y 1 C GLU 852 ? C GLU 808 
1079 1 Y 1 C GLU 853 ? C GLU 809 
1080 1 Y 1 C ASP 854 ? C ASP 810 
1081 1 Y 1 C LEU 855 ? C LEU 811 
1082 1 Y 1 C HIS 856 ? C HIS 812 
1083 1 Y 1 C HIS 857 ? C HIS 813 
1084 1 Y 1 C HIS 858 ? C HIS 814 
1085 1 Y 1 C HIS 859 ? C HIS 815 
1086 1 Y 1 C HIS 860 ? C HIS 816 
1087 1 Y 1 C HIS 861 ? C HIS 817 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
NAG C1   C N R 247 
NAG C2   C N R 248 
NAG C3   C N R 249 
NAG C4   C N S 250 
NAG C5   C N R 251 
NAG C6   C N N 252 
NAG C7   C N N 253 
NAG C8   C N N 254 
NAG N2   N N N 255 
NAG O1   O N N 256 
NAG O3   O N N 257 
NAG O4   O N N 258 
NAG O5   O N N 259 
NAG O6   O N N 260 
NAG O7   O N N 261 
NAG H1   H N N 262 
NAG H2   H N N 263 
NAG H3   H N N 264 
NAG H4   H N N 265 
NAG H5   H N N 266 
NAG H61  H N N 267 
NAG H62  H N N 268 
NAG H81  H N N 269 
NAG H82  H N N 270 
NAG H83  H N N 271 
NAG HN2  H N N 272 
NAG HO1  H N N 273 
NAG HO3  H N N 274 
NAG HO4  H N N 275 
NAG HO6  H N N 276 
PHE N    N N N 277 
PHE CA   C N S 278 
PHE C    C N N 279 
PHE O    O N N 280 
PHE CB   C N N 281 
PHE CG   C Y N 282 
PHE CD1  C Y N 283 
PHE CD2  C Y N 284 
PHE CE1  C Y N 285 
PHE CE2  C Y N 286 
PHE CZ   C Y N 287 
PHE OXT  O N N 288 
PHE H    H N N 289 
PHE H2   H N N 290 
PHE HA   H N N 291 
PHE HB2  H N N 292 
PHE HB3  H N N 293 
PHE HD1  H N N 294 
PHE HD2  H N N 295 
PHE HE1  H N N 296 
PHE HE2  H N N 297 
PHE HZ   H N N 298 
PHE HXT  H N N 299 
PRO N    N N N 300 
PRO CA   C N S 301 
PRO C    C N N 302 
PRO O    O N N 303 
PRO CB   C N N 304 
PRO CG   C N N 305 
PRO CD   C N N 306 
PRO OXT  O N N 307 
PRO H    H N N 308 
PRO HA   H N N 309 
PRO HB2  H N N 310 
PRO HB3  H N N 311 
PRO HG2  H N N 312 
PRO HG3  H N N 313 
PRO HD2  H N N 314 
PRO HD3  H N N 315 
PRO HXT  H N N 316 
SER N    N N N 317 
SER CA   C N S 318 
SER C    C N N 319 
SER O    O N N 320 
SER CB   C N N 321 
SER OG   O N N 322 
SER OXT  O N N 323 
SER H    H N N 324 
SER H2   H N N 325 
SER HA   H N N 326 
SER HB2  H N N 327 
SER HB3  H N N 328 
SER HG   H N N 329 
SER HXT  H N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
VAL N    N N N 399 
VAL CA   C N S 400 
VAL C    C N N 401 
VAL O    O N N 402 
VAL CB   C N N 403 
VAL CG1  C N N 404 
VAL CG2  C N N 405 
VAL OXT  O N N 406 
VAL H    H N N 407 
VAL H2   H N N 408 
VAL HA   H N N 409 
VAL HB   H N N 410 
VAL HG11 H N N 411 
VAL HG12 H N N 412 
VAL HG13 H N N 413 
VAL HG21 H N N 414 
VAL HG22 H N N 415 
VAL HG23 H N N 416 
VAL HXT  H N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
SER N   CA   sing N N 305 
SER N   H    sing N N 306 
SER N   H2   sing N N 307 
SER CA  C    sing N N 308 
SER CA  CB   sing N N 309 
SER CA  HA   sing N N 310 
SER C   O    doub N N 311 
SER C   OXT  sing N N 312 
SER CB  OG   sing N N 313 
SER CB  HB2  sing N N 314 
SER CB  HB3  sing N N 315 
SER OG  HG   sing N N 316 
SER OXT HXT  sing N N 317 
THR N   CA   sing N N 318 
THR N   H    sing N N 319 
THR N   H2   sing N N 320 
THR CA  C    sing N N 321 
THR CA  CB   sing N N 322 
THR CA  HA   sing N N 323 
THR C   O    doub N N 324 
THR C   OXT  sing N N 325 
THR CB  OG1  sing N N 326 
THR CB  CG2  sing N N 327 
THR CB  HB   sing N N 328 
THR OG1 HG1  sing N N 329 
THR CG2 HG21 sing N N 330 
THR CG2 HG22 sing N N 331 
THR CG2 HG23 sing N N 332 
THR OXT HXT  sing N N 333 
TRP N   CA   sing N N 334 
TRP N   H    sing N N 335 
TRP N   H2   sing N N 336 
TRP CA  C    sing N N 337 
TRP CA  CB   sing N N 338 
TRP CA  HA   sing N N 339 
TRP C   O    doub N N 340 
TRP C   OXT  sing N N 341 
TRP CB  CG   sing N N 342 
TRP CB  HB2  sing N N 343 
TRP CB  HB3  sing N N 344 
TRP CG  CD1  doub Y N 345 
TRP CG  CD2  sing Y N 346 
TRP CD1 NE1  sing Y N 347 
TRP CD1 HD1  sing N N 348 
TRP CD2 CE2  doub Y N 349 
TRP CD2 CE3  sing Y N 350 
TRP NE1 CE2  sing Y N 351 
TRP NE1 HE1  sing N N 352 
TRP CE2 CZ2  sing Y N 353 
TRP CE3 CZ3  doub Y N 354 
TRP CE3 HE3  sing N N 355 
TRP CZ2 CH2  doub Y N 356 
TRP CZ2 HZ2  sing N N 357 
TRP CZ3 CH2  sing Y N 358 
TRP CZ3 HZ3  sing N N 359 
TRP CH2 HH2  sing N N 360 
TRP OXT HXT  sing N N 361 
TYR N   CA   sing N N 362 
TYR N   H    sing N N 363 
TYR N   H2   sing N N 364 
TYR CA  C    sing N N 365 
TYR CA  CB   sing N N 366 
TYR CA  HA   sing N N 367 
TYR C   O    doub N N 368 
TYR C   OXT  sing N N 369 
TYR CB  CG   sing N N 370 
TYR CB  HB2  sing N N 371 
TYR CB  HB3  sing N N 372 
TYR CG  CD1  doub Y N 373 
TYR CG  CD2  sing Y N 374 
TYR CD1 CE1  sing Y N 375 
TYR CD1 HD1  sing N N 376 
TYR CD2 CE2  doub Y N 377 
TYR CD2 HD2  sing N N 378 
TYR CE1 CZ   doub Y N 379 
TYR CE1 HE1  sing N N 380 
TYR CE2 CZ   sing Y N 381 
TYR CE2 HE2  sing N N 382 
TYR CZ  OH   sing N N 383 
TYR OH  HH   sing N N 384 
TYR OXT HXT  sing N N 385 
VAL N   CA   sing N N 386 
VAL N   H    sing N N 387 
VAL N   H2   sing N N 388 
VAL CA  C    sing N N 389 
VAL CA  CB   sing N N 390 
VAL CA  HA   sing N N 391 
VAL C   O    doub N N 392 
VAL C   OXT  sing N N 393 
VAL CB  CG1  sing N N 394 
VAL CB  CG2  sing N N 395 
VAL CB  HB   sing N N 396 
VAL CG1 HG11 sing N N 397 
VAL CG1 HG12 sing N N 398 
VAL CG1 HG13 sing N N 399 
VAL CG2 HG21 sing N N 400 
VAL CG2 HG22 sing N N 401 
VAL CG2 HG23 sing N N 402 
VAL OXT HXT  sing N N 403 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-11-22 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8V2A 
_em_admin.last_update        2024-11-20 
_em_admin.map_release_date   2024-11-20 
_em_admin.title              'Cryo-EM structure of human type I OSM receptor complex: model for assembly core region' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 2 2 9606 'Homo sapiens' ? ? ? ? ? 
? ? 3 3 9606 'Homo sapiens' ? ? ? ? ? 
# 
loop_
_em_entity_assembly_recombinant.cell 
_em_entity_assembly_recombinant.entity_assembly_id 
_em_entity_assembly_recombinant.id 
_em_entity_assembly_recombinant.ncbi_tax_id 
_em_entity_assembly_recombinant.organism 
_em_entity_assembly_recombinant.plasmid 
_em_entity_assembly_recombinant.strain 
? 2 2 10029 'Cricetulus griseus' ? ? 
? 3 3 9606  'Homo sapiens'       ? ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         40 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
4 NAG 1 n 
4 NAG 2 n 
# 
_atom_sites.entry_id                    8V2A 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 1   ? 139.332 179.888 155.737 1.00 87.05  ? 26  ALA A N   1 
ATOM   2    C CA  . ALA A 1 1   ? 140.552 180.004 156.527 1.00 87.05  ? 26  ALA A CA  1 
ATOM   3    C C   . ALA A 1 1   ? 140.958 178.653 157.104 1.00 87.05  ? 26  ALA A C   1 
ATOM   4    O O   . ALA A 1 1   ? 141.099 177.673 156.373 1.00 87.05  ? 26  ALA A O   1 
ATOM   5    C CB  . ALA A 1 1   ? 140.367 181.024 157.639 1.00 87.05  ? 26  ALA A CB  1 
ATOM   6    N N   . ALA A 1 2   ? 141.149 178.610 158.420 1.00 83.35  ? 27  ALA A N   1 
ATOM   7    C CA  . ALA A 1 2   ? 141.518 177.366 159.082 1.00 83.35  ? 27  ALA A CA  1 
ATOM   8    C C   . ALA A 1 2   ? 140.336 176.406 159.088 1.00 83.35  ? 27  ALA A C   1 
ATOM   9    O O   . ALA A 1 2   ? 139.212 176.786 159.429 1.00 83.35  ? 27  ALA A O   1 
ATOM   10   C CB  . ALA A 1 2   ? 141.987 177.642 160.509 1.00 83.35  ? 27  ALA A CB  1 
ATOM   11   N N   . ILE A 1 3   ? 140.595 175.160 158.716 1.00 77.51  ? 28  ILE A N   1 
ATOM   12   C CA  . ILE A 1 3   ? 139.549 174.151 158.630 1.00 77.51  ? 28  ILE A CA  1 
ATOM   13   C C   . ILE A 1 3   ? 139.130 173.730 160.033 1.00 77.51  ? 28  ILE A C   1 
ATOM   14   O O   . ILE A 1 3   ? 139.958 173.637 160.948 1.00 77.51  ? 28  ILE A O   1 
ATOM   15   C CB  . ILE A 1 3   ? 140.031 172.955 157.789 1.00 77.51  ? 28  ILE A CB  1 
ATOM   16   C CG1 . ILE A 1 3   ? 141.310 172.359 158.381 1.00 77.51  ? 28  ILE A CG1 1 
ATOM   17   C CG2 . ILE A 1 3   ? 140.259 173.380 156.346 1.00 77.51  ? 28  ILE A CG2 1 
ATOM   18   C CD1 . ILE A 1 3   ? 141.783 171.111 157.674 1.00 77.51  ? 28  ILE A CD1 1 
ATOM   19   N N   . GLY A 1 4   ? 137.829 173.497 160.210 1.00 76.38  ? 29  GLY A N   1 
ATOM   20   C CA  . GLY A 1 4   ? 137.336 173.088 161.515 1.00 76.38  ? 29  GLY A CA  1 
ATOM   21   C C   . GLY A 1 4   ? 137.802 171.696 161.895 1.00 76.38  ? 29  GLY A C   1 
ATOM   22   O O   . GLY A 1 4   ? 138.248 171.460 163.022 1.00 76.38  ? 29  GLY A O   1 
ATOM   23   N N   . SER A 1 5   ? 137.706 170.757 160.960 1.00 78.24  ? 30  SER A N   1 
ATOM   24   C CA  . SER A 1 5   ? 138.197 169.400 161.148 1.00 78.24  ? 30  SER A CA  1 
ATOM   25   C C   . SER A 1 5   ? 139.466 169.221 160.329 1.00 78.24  ? 30  SER A C   1 
ATOM   26   O O   . SER A 1 5   ? 139.474 169.494 159.124 1.00 78.24  ? 30  SER A O   1 
ATOM   27   C CB  . SER A 1 5   ? 137.146 168.370 160.729 1.00 78.24  ? 30  SER A CB  1 
ATOM   28   O OG  . SER A 1 5   ? 137.258 168.057 159.352 1.00 78.24  ? 30  SER A OG  1 
ATOM   29   N N   . CYS A 1 6   ? 140.533 168.754 160.982 1.00 73.57  ? 31  CYS A N   1 
ATOM   30   C CA  . CYS A 1 6   ? 141.816 168.616 160.305 1.00 73.57  ? 31  CYS A CA  1 
ATOM   31   C C   . CYS A 1 6   ? 141.770 167.558 159.208 1.00 73.57  ? 31  CYS A C   1 
ATOM   32   O O   . CYS A 1 6   ? 142.617 167.565 158.307 1.00 73.57  ? 31  CYS A O   1 
ATOM   33   C CB  . CYS A 1 6   ? 142.914 168.293 161.318 1.00 73.57  ? 31  CYS A CB  1 
ATOM   34   S SG  . CYS A 1 6   ? 142.590 166.851 162.358 1.00 73.57  ? 31  CYS A SG  1 
ATOM   35   N N   . SER A 1 7   ? 140.800 166.650 159.262 1.00 69.48  ? 32  SER A N   1 
ATOM   36   C CA  . SER A 1 7   ? 140.641 165.634 158.233 1.00 69.48  ? 32  SER A CA  1 
ATOM   37   C C   . SER A 1 7   ? 139.184 165.203 158.189 1.00 69.48  ? 32  SER A C   1 
ATOM   38   O O   . SER A 1 7   ? 138.398 165.507 159.090 1.00 69.48  ? 32  SER A O   1 
ATOM   39   C CB  . SER A 1 7   ? 141.554 164.429 158.482 1.00 69.48  ? 32  SER A CB  1 
ATOM   40   O OG  . SER A 1 7   ? 141.721 163.663 157.303 1.00 69.48  ? 32  SER A OG  1 
ATOM   41   N N   . LYS A 1 8   ? 138.828 164.491 157.122 1.00 71.01  ? 33  LYS A N   1 
ATOM   42   C CA  . LYS A 1 8   ? 137.471 163.997 156.938 1.00 71.01  ? 33  LYS A CA  1 
ATOM   43   C C   . LYS A 1 8   ? 137.407 162.487 156.749 1.00 71.01  ? 33  LYS A C   1 
ATOM   44   O O   . LYS A 1 8   ? 136.322 161.953 156.499 1.00 71.01  ? 33  LYS A O   1 
ATOM   45   C CB  . LYS A 1 8   ? 136.813 164.698 155.743 1.00 71.01  ? 33  LYS A CB  1 
ATOM   46   C CG  . LYS A 1 8   ? 135.301 164.828 155.849 1.00 71.01  ? 33  LYS A CG  1 
ATOM   47   C CD  . LYS A 1 8   ? 134.893 165.499 157.149 1.00 71.01  ? 33  LYS A CD  1 
ATOM   48   C CE  . LYS A 1 8   ? 133.383 165.511 157.312 1.00 71.01  ? 33  LYS A CE  1 
ATOM   49   N NZ  . LYS A 1 8   ? 132.700 166.101 156.128 1.00 71.01  ? 33  LYS A NZ  1 
ATOM   50   N N   . GLU A 1 9   ? 138.531 161.783 156.869 1.00 67.07  ? 34  GLU A N   1 
ATOM   51   C CA  . GLU A 1 9   ? 138.579 160.342 156.658 1.00 67.07  ? 34  GLU A CA  1 
ATOM   52   C C   . GLU A 1 9   ? 138.599 159.640 158.014 1.00 67.07  ? 34  GLU A C   1 
ATOM   53   O O   . GLU A 1 9   ? 139.617 159.650 158.720 1.00 67.07  ? 34  GLU A O   1 
ATOM   54   C CB  . GLU A 1 9   ? 139.785 159.958 155.808 1.00 67.07  ? 34  GLU A CB  1 
ATOM   55   C CG  . GLU A 1 9   ? 139.770 160.558 154.413 1.00 67.07  ? 34  GLU A CG  1 
ATOM   56   C CD  . GLU A 1 9   ? 140.881 160.021 153.535 1.00 67.07  ? 34  GLU A CD  1 
ATOM   57   O OE1 . GLU A 1 9   ? 141.551 159.052 153.948 1.00 67.07  ? 34  GLU A OE1 1 
ATOM   58   O OE2 . GLU A 1 9   ? 141.087 160.572 152.433 1.00 67.07  ? 34  GLU A OE2 1 
ATOM   59   N N   . TYR A 1 10  ? 137.461 159.032 158.364 1.00 61.93  ? 35  TYR A N   1 
ATOM   60   C CA  . TYR A 1 10  ? 137.320 158.331 159.636 1.00 61.93  ? 35  TYR A CA  1 
ATOM   61   C C   . TYR A 1 10  ? 138.405 157.279 159.816 1.00 61.93  ? 35  TYR A C   1 
ATOM   62   O O   . TYR A 1 10  ? 138.955 157.123 160.913 1.00 61.93  ? 35  TYR A O   1 
ATOM   63   C CB  . TYR A 1 10  ? 135.928 157.698 159.705 1.00 61.93  ? 35  TYR A CB  1 
ATOM   64   C CG  . TYR A 1 10  ? 135.642 156.878 160.943 1.00 61.93  ? 35  TYR A CG  1 
ATOM   65   C CD1 . TYR A 1 10  ? 134.963 157.428 162.020 1.00 61.93  ? 35  TYR A CD1 1 
ATOM   66   C CD2 . TYR A 1 10  ? 136.020 155.544 161.021 1.00 61.93  ? 35  TYR A CD2 1 
ATOM   67   C CE1 . TYR A 1 10  ? 134.690 156.681 163.147 1.00 61.93  ? 35  TYR A CE1 1 
ATOM   68   C CE2 . TYR A 1 10  ? 135.755 154.792 162.145 1.00 61.93  ? 35  TYR A CE2 1 
ATOM   69   C CZ  . TYR A 1 10  ? 135.087 155.363 163.203 1.00 61.93  ? 35  TYR A CZ  1 
ATOM   70   O OH  . TYR A 1 10  ? 134.818 154.612 164.323 1.00 61.93  ? 35  TYR A OH  1 
ATOM   71   N N   . ARG A 1 11  ? 138.734 156.554 158.746 1.00 62.49  ? 36  ARG A N   1 
ATOM   72   C CA  . ARG A 1 11  ? 139.671 155.442 158.860 1.00 62.49  ? 36  ARG A CA  1 
ATOM   73   C C   . ARG A 1 11  ? 141.073 155.932 159.201 1.00 62.49  ? 36  ARG A C   1 
ATOM   74   O O   . ARG A 1 11  ? 141.707 155.430 160.138 1.00 62.49  ? 36  ARG A O   1 
ATOM   75   C CB  . ARG A 1 11  ? 139.678 154.628 157.565 1.00 62.49  ? 36  ARG A CB  1 
ATOM   76   C CG  . ARG A 1 11  ? 138.533 153.631 157.452 1.00 62.49  ? 36  ARG A CG  1 
ATOM   77   C CD  . ARG A 1 11  ? 137.237 154.313 157.041 1.00 62.49  ? 36  ARG A CD  1 
ATOM   78   N NE  . ARG A 1 11  ? 136.116 153.380 156.985 1.00 62.49  ? 36  ARG A NE  1 
ATOM   79   C CZ  . ARG A 1 11  ? 134.871 153.728 156.680 1.00 62.49  ? 36  ARG A CZ  1 
ATOM   80   N NH1 . ARG A 1 11  ? 133.912 152.813 156.653 1.00 62.49  ? 36  ARG A NH1 1 
ATOM   81   N NH2 . ARG A 1 11  ? 134.583 154.992 156.402 1.00 62.49  ? 36  ARG A NH2 1 
ATOM   82   N N   . VAL A 1 12  ? 141.577 156.918 158.454 1.00 54.59  ? 37  VAL A N   1 
ATOM   83   C CA  . VAL A 1 12  ? 142.921 157.406 158.739 1.00 54.59  ? 37  VAL A CA  1 
ATOM   84   C C   . VAL A 1 12  ? 142.949 158.133 160.076 1.00 54.59  ? 37  VAL A C   1 
ATOM   85   O O   . VAL A 1 12  ? 143.965 158.106 160.779 1.00 54.59  ? 37  VAL A O   1 
ATOM   86   C CB  . VAL A 1 12  ? 143.448 158.299 157.598 1.00 54.59  ? 37  VAL A CB  1 
ATOM   87   C CG1 . VAL A 1 12  ? 142.730 159.631 157.575 1.00 54.59  ? 37  VAL A CG1 1 
ATOM   88   C CG2 . VAL A 1 12  ? 144.950 158.501 157.731 1.00 54.59  ? 37  VAL A CG2 1 
ATOM   89   N N   . LEU A 1 13  ? 141.839 158.766 160.472 1.00 52.10  ? 38  LEU A N   1 
ATOM   90   C CA  . LEU A 1 13  ? 141.815 159.423 161.776 1.00 52.10  ? 38  LEU A CA  1 
ATOM   91   C C   . LEU A 1 13  ? 141.921 158.406 162.907 1.00 52.10  ? 38  LEU A C   1 
ATOM   92   O O   . LEU A 1 13  ? 142.698 158.594 163.854 1.00 52.10  ? 38  LEU A O   1 
ATOM   93   C CB  . LEU A 1 13  ? 140.546 160.260 161.917 1.00 52.10  ? 38  LEU A CB  1 
ATOM   94   C CG  . LEU A 1 13  ? 140.711 161.582 162.666 1.00 52.10  ? 38  LEU A CG  1 
ATOM   95   C CD1 . LEU A 1 13  ? 141.830 162.406 162.052 1.00 52.10  ? 38  LEU A CD1 1 
ATOM   96   C CD2 . LEU A 1 13  ? 139.409 162.361 162.662 1.00 52.10  ? 38  LEU A CD2 1 
ATOM   97   N N   . LEU A 1 14  ? 141.154 157.316 162.821 1.00 48.75  ? 39  LEU A N   1 
ATOM   98   C CA  . LEU A 1 14  ? 141.233 156.279 163.844 1.00 48.75  ? 39  LEU A CA  1 
ATOM   99   C C   . LEU A 1 14  ? 142.603 155.614 163.846 1.00 48.75  ? 39  LEU A C   1 
ATOM   100  O O   . LEU A 1 14  ? 143.134 155.273 164.912 1.00 48.75  ? 39  LEU A O   1 
ATOM   101  C CB  . LEU A 1 14  ? 140.127 155.248 163.627 1.00 48.75  ? 39  LEU A CB  1 
ATOM   102  C CG  . LEU A 1 14  ? 139.806 154.335 164.808 1.00 48.75  ? 39  LEU A CG  1 
ATOM   103  C CD1 . LEU A 1 14  ? 139.871 155.108 166.111 1.00 48.75  ? 39  LEU A CD1 1 
ATOM   104  C CD2 . LEU A 1 14  ? 138.433 153.719 164.626 1.00 48.75  ? 39  LEU A CD2 1 
ATOM   105  N N   . GLY A 1 15  ? 143.195 155.426 162.664 1.00 44.58  ? 40  GLY A N   1 
ATOM   106  C CA  . GLY A 1 15  ? 144.544 154.887 162.607 1.00 44.58  ? 40  GLY A CA  1 
ATOM   107  C C   . GLY A 1 15  ? 145.555 155.793 163.282 1.00 44.58  ? 40  GLY A C   1 
ATOM   108  O O   . GLY A 1 15  ? 146.434 155.326 164.013 1.00 44.58  ? 40  GLY A O   1 
ATOM   109  N N   . GLN A 1 16  ? 145.443 157.103 163.048 1.00 42.68  ? 41  GLN A N   1 
ATOM   110  C CA  . GLN A 1 16  ? 146.322 158.056 163.715 1.00 42.68  ? 41  GLN A CA  1 
ATOM   111  C C   . GLN A 1 16  ? 146.153 157.993 165.226 1.00 42.68  ? 41  GLN A C   1 
ATOM   112  O O   . GLN A 1 16  ? 147.141 158.014 165.967 1.00 42.68  ? 41  GLN A O   1 
ATOM   113  C CB  . GLN A 1 16  ? 146.044 159.471 163.208 1.00 42.68  ? 41  GLN A CB  1 
ATOM   114  C CG  . GLN A 1 16  ? 146.541 159.744 161.802 1.00 42.68  ? 41  GLN A CG  1 
ATOM   115  C CD  . GLN A 1 16  ? 145.944 161.005 161.215 1.00 42.68  ? 41  GLN A CD  1 
ATOM   116  O OE1 . GLN A 1 16  ? 146.340 162.115 161.566 1.00 42.68  ? 41  GLN A OE1 1 
ATOM   117  N NE2 . GLN A 1 16  ? 144.982 160.840 160.315 1.00 42.68  ? 41  GLN A NE2 1 
ATOM   118  N N   . LEU A 1 17  ? 144.908 157.913 165.701 1.00 43.10  ? 42  LEU A N   1 
ATOM   119  C CA  . LEU A 1 17  ? 144.669 157.841 167.141 1.00 43.10  ? 42  LEU A CA  1 
ATOM   120  C C   . LEU A 1 17  ? 145.303 156.591 167.746 1.00 43.10  ? 42  LEU A C   1 
ATOM   121  O O   . LEU A 1 17  ? 145.984 156.658 168.782 1.00 43.10  ? 42  LEU A O   1 
ATOM   122  C CB  . LEU A 1 17  ? 143.167 157.872 167.424 1.00 43.10  ? 42  LEU A CB  1 
ATOM   123  C CG  . LEU A 1 17  ? 142.496 159.246 167.416 1.00 43.10  ? 42  LEU A CG  1 
ATOM   124  C CD1 . LEU A 1 17  ? 140.984 159.103 167.431 1.00 43.10  ? 42  LEU A CD1 1 
ATOM   125  C CD2 . LEU A 1 17  ? 142.966 160.075 168.597 1.00 43.10  ? 42  LEU A CD2 1 
ATOM   126  N N   . GLN A 1 18  ? 145.084 155.436 167.110 1.00 40.24  ? 43  GLN A N   1 
ATOM   127  C CA  . GLN A 1 18  ? 145.637 154.191 167.632 1.00 40.24  ? 43  GLN A CA  1 
ATOM   128  C C   . GLN A 1 18  ? 147.160 154.219 167.637 1.00 40.24  ? 43  GLN A C   1 
ATOM   129  O O   . GLN A 1 18  ? 147.794 153.797 168.613 1.00 40.24  ? 43  GLN A O   1 
ATOM   130  C CB  . GLN A 1 18  ? 145.124 153.006 166.815 1.00 40.24  ? 43  GLN A CB  1 
ATOM   131  C CG  . GLN A 1 18  ? 143.639 152.742 166.978 1.00 40.24  ? 43  GLN A CG  1 
ATOM   132  C CD  . GLN A 1 18  ? 143.128 151.683 166.023 1.00 40.24  ? 43  GLN A CD  1 
ATOM   133  O OE1 . GLN A 1 18  ? 141.972 151.269 166.098 1.00 40.24  ? 43  GLN A OE1 1 
ATOM   134  N NE2 . GLN A 1 18  ? 143.990 151.238 165.117 1.00 40.24  ? 43  GLN A NE2 1 
ATOM   135  N N   . LYS A 1 19  ? 147.767 154.715 166.555 1.00 38.79  ? 44  LYS A N   1 
ATOM   136  C CA  . LYS A 1 19  ? 149.222 154.798 166.504 1.00 38.79  ? 44  LYS A CA  1 
ATOM   137  C C   . LYS A 1 19  ? 149.757 155.746 167.569 1.00 38.79  ? 44  LYS A C   1 
ATOM   138  O O   . LYS A 1 19  ? 150.782 155.464 168.202 1.00 38.79  ? 44  LYS A O   1 
ATOM   139  C CB  . LYS A 1 19  ? 149.671 155.240 165.113 1.00 38.79  ? 44  LYS A CB  1 
ATOM   140  C CG  . LYS A 1 19  ? 149.545 154.166 164.045 1.00 38.79  ? 44  LYS A CG  1 
ATOM   141  C CD  . LYS A 1 19  ? 150.767 153.262 164.025 1.00 38.79  ? 44  LYS A CD  1 
ATOM   142  C CE  . LYS A 1 19  ? 150.785 152.383 162.785 1.00 38.79  ? 44  LYS A CE  1 
ATOM   143  N NZ  . LYS A 1 19  ? 152.048 151.603 162.675 1.00 38.79  ? 44  LYS A NZ  1 
ATOM   144  N N   . GLN A 1 20  ? 149.068 156.868 167.791 1.00 41.27  ? 45  GLN A N   1 
ATOM   145  C CA  . GLN A 1 20  ? 149.494 157.816 168.815 1.00 41.27  ? 45  GLN A CA  1 
ATOM   146  C C   . GLN A 1 20  ? 149.492 157.171 170.194 1.00 41.27  ? 45  GLN A C   1 
ATOM   147  O O   . GLN A 1 20  ? 150.450 157.319 170.963 1.00 41.27  ? 45  GLN A O   1 
ATOM   148  C CB  . GLN A 1 20  ? 148.583 159.043 168.805 1.00 41.27  ? 45  GLN A CB  1 
ATOM   149  C CG  . GLN A 1 20  ? 148.879 160.044 167.710 1.00 41.27  ? 45  GLN A CG  1 
ATOM   150  C CD  . GLN A 1 20  ? 147.694 160.938 167.422 1.00 41.27  ? 45  GLN A CD  1 
ATOM   151  O OE1 . GLN A 1 20  ? 146.544 160.514 167.530 1.00 41.27  ? 45  GLN A OE1 1 
ATOM   152  N NE2 . GLN A 1 20  ? 147.966 162.182 167.055 1.00 41.27  ? 45  GLN A NE2 1 
ATOM   153  N N   . THR A 1 21  ? 148.415 156.458 170.529 1.00 41.38  ? 46  THR A N   1 
ATOM   154  C CA  . THR A 1 21  ? 148.353 155.830 171.846 1.00 41.38  ? 46  THR A CA  1 
ATOM   155  C C   . THR A 1 21  ? 149.408 154.738 171.992 1.00 41.38  ? 46  THR A C   1 
ATOM   156  O O   . THR A 1 21  ? 150.089 154.656 173.025 1.00 41.38  ? 46  THR A O   1 
ATOM   157  C CB  . THR A 1 21  ? 146.958 155.264 172.100 1.00 41.38  ? 46  THR A CB  1 
ATOM   158  O OG1 . THR A 1 21  ? 146.565 154.441 170.996 1.00 41.38  ? 46  THR A OG1 1 
ATOM   159  C CG2 . THR A 1 21  ? 145.958 156.391 172.271 1.00 41.38  ? 46  THR A CG2 1 
ATOM   160  N N   . ASP A 1 22  ? 149.566 153.895 170.966 1.00 46.87  ? 47  ASP A N   1 
ATOM   161  C CA  . ASP A 1 22  ? 150.561 152.830 171.041 1.00 46.87  ? 47  ASP A CA  1 
ATOM   162  C C   . ASP A 1 22  ? 151.975 153.387 171.144 1.00 46.87  ? 47  ASP A C   1 
ATOM   163  O O   . ASP A 1 22  ? 152.848 152.751 171.745 1.00 46.87  ? 47  ASP A O   1 
ATOM   164  C CB  . ASP A 1 22  ? 150.439 151.909 169.827 1.00 46.87  ? 47  ASP A CB  1 
ATOM   165  C CG  . ASP A 1 22  ? 149.264 150.958 169.934 1.00 46.87  ? 47  ASP A CG  1 
ATOM   166  O OD1 . ASP A 1 22  ? 148.359 151.028 169.077 1.00 46.87  ? 47  ASP A OD1 1 
ATOM   167  O OD2 . ASP A 1 22  ? 149.244 150.141 170.878 1.00 46.87  ? 47  ASP A OD2 1 
ATOM   168  N N   . LEU A 1 23  ? 152.222 154.566 170.571 1.00 48.46  ? 48  LEU A N   1 
ATOM   169  C CA  . LEU A 1 23  ? 153.543 155.172 170.684 1.00 48.46  ? 48  LEU A CA  1 
ATOM   170  C C   . LEU A 1 23  ? 153.755 155.808 172.053 1.00 48.46  ? 48  LEU A C   1 
ATOM   171  O O   . LEU A 1 23  ? 154.829 155.662 172.646 1.00 48.46  ? 48  LEU A O   1 
ATOM   172  C CB  . LEU A 1 23  ? 153.740 156.210 169.579 1.00 48.46  ? 48  LEU A CB  1 
ATOM   173  C CG  . LEU A 1 23  ? 155.029 157.029 169.652 1.00 48.46  ? 48  LEU A CG  1 
ATOM   174  C CD1 . LEU A 1 23  ? 156.245 156.126 169.527 1.00 48.46  ? 48  LEU A CD1 1 
ATOM   175  C CD2 . LEU A 1 23  ? 155.041 158.106 168.579 1.00 48.46  ? 48  LEU A CD2 1 
ATOM   176  N N   . MET A 1 24  ? 152.749 156.513 172.569 1.00 49.13  ? 49  MET A N   1 
ATOM   177  C CA  . MET A 1 24  ? 152.871 157.189 173.856 1.00 49.13  ? 49  MET A CA  1 
ATOM   178  C C   . MET A 1 24  ? 152.749 156.243 175.043 1.00 49.13  ? 49  MET A C   1 
ATOM   179  O O   . MET A 1 24  ? 152.928 156.682 176.184 1.00 49.13  ? 49  MET A O   1 
ATOM   180  C CB  . MET A 1 24  ? 151.819 158.296 173.969 1.00 49.13  ? 49  MET A CB  1 
ATOM   181  C CG  . MET A 1 24  ? 151.986 159.414 172.954 1.00 49.13  ? 49  MET A CG  1 
ATOM   182  S SD  . MET A 1 24  ? 150.494 160.407 172.769 1.00 49.13  ? 49  MET A SD  1 
ATOM   183  C CE  . MET A 1 24  ? 150.171 160.845 174.474 1.00 49.13  ? 49  MET A CE  1 
ATOM   184  N N   . GLN A 1 25  ? 152.450 154.967 174.809 1.00 49.42  ? 50  GLN A N   1 
ATOM   185  C CA  . GLN A 1 25  ? 152.386 153.975 175.877 1.00 49.42  ? 50  GLN A CA  1 
ATOM   186  C C   . GLN A 1 25  ? 153.771 153.506 176.365 1.00 49.42  ? 50  GLN A C   1 
ATOM   187  O O   . GLN A 1 25  ? 153.860 152.470 177.034 1.00 49.42  ? 50  GLN A O   1 
ATOM   188  C CB  . GLN A 1 25  ? 151.563 152.773 175.405 1.00 49.42  ? 50  GLN A CB  1 
ATOM   189  C CG  . GLN A 1 25  ? 150.955 151.930 176.507 1.00 49.42  ? 50  GLN A CG  1 
ATOM   190  C CD  . GLN A 1 25  ? 150.432 150.607 175.992 1.00 49.42  ? 50  GLN A CD  1 
ATOM   191  O OE1 . GLN A 1 25  ? 150.016 150.498 174.839 1.00 49.42  ? 50  GLN A OE1 1 
ATOM   192  N NE2 . GLN A 1 25  ? 150.471 149.586 176.838 1.00 49.42  ? 50  GLN A NE2 1 
ATOM   193  N N   . ASP A 1 26  ? 154.851 154.227 176.066 1.00 55.49  ? 51  ASP A N   1 
ATOM   194  C CA  . ASP A 1 26  ? 156.208 153.743 176.314 1.00 55.49  ? 51  ASP A CA  1 
ATOM   195  C C   . ASP A 1 26  ? 156.725 154.238 177.666 1.00 55.49  ? 51  ASP A C   1 
ATOM   196  O O   . ASP A 1 26  ? 157.149 155.398 177.806 1.00 55.49  ? 51  ASP A O   1 
ATOM   197  C CB  . ASP A 1 26  ? 157.140 154.159 175.181 1.00 55.49  ? 51  ASP A CB  1 
ATOM   198  C CG  . ASP A 1 26  ? 157.271 153.091 174.116 1.00 55.49  ? 51  ASP A CG  1 
ATOM   199  O OD1 . ASP A 1 26  ? 157.089 151.900 174.445 1.00 55.49  ? 51  ASP A OD1 1 
ATOM   200  O OD2 . ASP A 1 26  ? 157.558 153.440 172.952 1.00 55.49  ? 51  ASP A OD2 1 
ATOM   201  N N   . THR A 1 27  ? 156.703 153.338 178.655 1.00 52.40  ? 52  THR A N   1 
ATOM   202  C CA  . THR A 1 27  ? 157.322 153.629 179.943 1.00 52.40  ? 52  THR A CA  1 
ATOM   203  C C   . THR A 1 27  ? 158.808 153.908 179.781 1.00 52.40  ? 52  THR A C   1 
ATOM   204  O O   . THR A 1 27  ? 159.331 154.860 180.367 1.00 52.40  ? 52  THR A O   1 
ATOM   205  C CB  . THR A 1 27  ? 157.104 152.470 180.915 1.00 52.40  ? 52  THR A CB  1 
ATOM   206  O OG1 . THR A 1 27  ? 157.781 151.304 180.431 1.00 52.40  ? 52  THR A OG1 1 
ATOM   207  C CG2 . THR A 1 27  ? 155.623 152.164 181.057 1.00 52.40  ? 52  THR A CG2 1 
ATOM   208  N N   . SER A 1 28  ? 159.499 153.102 178.971 1.00 54.17  ? 53  SER A N   1 
ATOM   209  C CA  . SER A 1 28  ? 160.917 153.334 178.725 1.00 54.17  ? 53  SER A CA  1 
ATOM   210  C C   . SER A 1 28  ? 161.160 154.692 178.083 1.00 54.17  ? 53  SER A C   1 
ATOM   211  O O   . SER A 1 28  ? 162.244 155.265 178.238 1.00 54.17  ? 53  SER A O   1 
ATOM   212  C CB  . SER A 1 28  ? 161.483 152.223 177.842 1.00 54.17  ? 53  SER A CB  1 
ATOM   213  O OG  . SER A 1 28  ? 160.852 152.210 176.573 1.00 54.17  ? 53  SER A OG  1 
ATOM   214  N N   . ARG A 1 29  ? 160.173 155.221 177.359 1.00 56.59  ? 54  ARG A N   1 
ATOM   215  C CA  . ARG A 1 29  ? 160.332 156.539 176.756 1.00 56.59  ? 54  ARG A CA  1 
ATOM   216  C C   . ARG A 1 29  ? 160.168 157.642 177.791 1.00 56.59  ? 54  ARG A C   1 
ATOM   217  O O   . ARG A 1 29  ? 160.970 158.581 177.841 1.00 56.59  ? 54  ARG A O   1 
ATOM   218  C CB  . ARG A 1 29  ? 159.332 156.729 175.617 1.00 56.59  ? 54  ARG A CB  1 
ATOM   219  C CG  . ARG A 1 29  ? 159.880 156.411 174.237 1.00 56.59  ? 54  ARG A CG  1 
ATOM   220  C CD  . ARG A 1 29  ? 160.460 157.648 173.576 1.00 56.59  ? 54  ARG A CD  1 
ATOM   221  N NE  . ARG A 1 29  ? 159.456 158.694 173.408 1.00 56.59  ? 54  ARG A NE  1 
ATOM   222  C CZ  . ARG A 1 29  ? 158.591 158.745 172.401 1.00 56.59  ? 54  ARG A CZ  1 
ATOM   223  N NH1 . ARG A 1 29  ? 158.604 157.806 171.465 1.00 56.59  ? 54  ARG A NH1 1 
ATOM   224  N NH2 . ARG A 1 29  ? 157.711 159.734 172.329 1.00 56.59  ? 54  ARG A NH2 1 
ATOM   225  N N   . LEU A 1 30  ? 159.127 157.559 178.621 1.00 51.76  ? 55  LEU A N   1 
ATOM   226  C CA  . LEU A 1 30  ? 158.816 158.685 179.506 1.00 51.76  ? 55  LEU A CA  1 
ATOM   227  C C   . LEU A 1 30  ? 159.314 158.502 180.939 1.00 51.76  ? 55  LEU A C   1 
ATOM   228  O O   . LEU A 1 30  ? 160.047 159.354 181.449 1.00 51.76  ? 55  LEU A O   1 
ATOM   229  C CB  . LEU A 1 30  ? 157.312 158.973 179.503 1.00 51.76  ? 55  LEU A CB  1 
ATOM   230  C CG  . LEU A 1 30  ? 156.982 160.423 179.863 1.00 51.76  ? 55  LEU A CG  1 
ATOM   231  C CD1 . LEU A 1 30  ? 157.821 161.383 179.035 1.00 51.76  ? 55  LEU A CD1 1 
ATOM   232  C CD2 . LEU A 1 30  ? 155.507 160.709 179.675 1.00 51.76  ? 55  LEU A CD2 1 
ATOM   233  N N   . LEU A 1 31  ? 158.927 157.413 181.605 1.00 49.01  ? 56  LEU A N   1 
ATOM   234  C CA  . LEU A 1 31  ? 159.166 157.304 183.042 1.00 49.01  ? 56  LEU A CA  1 
ATOM   235  C C   . LEU A 1 31  ? 160.643 157.088 183.353 1.00 49.01  ? 56  LEU A C   1 
ATOM   236  O O   . LEU A 1 31  ? 161.203 157.754 184.230 1.00 49.01  ? 56  LEU A O   1 
ATOM   237  C CB  . LEU A 1 31  ? 158.326 156.170 183.630 1.00 49.01  ? 56  LEU A CB  1 
ATOM   238  C CG  . LEU A 1 31  ? 158.647 155.764 185.071 1.00 49.01  ? 56  LEU A CG  1 
ATOM   239  C CD1 . LEU A 1 31  ? 158.467 156.937 186.017 1.00 49.01  ? 56  LEU A CD1 1 
ATOM   240  C CD2 . LEU A 1 31  ? 157.784 154.591 185.505 1.00 49.01  ? 56  LEU A CD2 1 
ATOM   241  N N   . ASP A 1 32  ? 161.283 156.149 182.657 1.00 57.04  ? 57  ASP A N   1 
ATOM   242  C CA  . ASP A 1 32  ? 162.674 155.822 182.962 1.00 57.04  ? 57  ASP A CA  1 
ATOM   243  C C   . ASP A 1 32  ? 163.623 157.014 182.868 1.00 57.04  ? 57  ASP A C   1 
ATOM   244  O O   . ASP A 1 32  ? 164.516 157.119 183.729 1.00 57.04  ? 57  ASP A O   1 
ATOM   245  C CB  . ASP A 1 32  ? 163.149 154.682 182.053 1.00 57.04  ? 57  ASP A CB  1 
ATOM   246  C CG  . ASP A 1 32  ? 164.520 154.167 182.437 1.00 57.04  ? 57  ASP A CG  1 
ATOM   247  O OD1 . ASP A 1 32  ? 164.627 153.467 183.465 1.00 57.04  ? 57  ASP A OD1 1 
ATOM   248  O OD2 . ASP A 1 32  ? 165.493 154.466 181.713 1.00 57.04  ? 57  ASP A OD2 1 
ATOM   249  N N   . PRO A 1 33  ? 163.520 157.912 181.880 1.00 57.25  ? 58  PRO A N   1 
ATOM   250  C CA  . PRO A 1 33  ? 164.376 159.110 181.915 1.00 57.25  ? 58  PRO A CA  1 
ATOM   251  C C   . PRO A 1 33  ? 164.213 159.932 183.181 1.00 57.25  ? 58  PRO A C   1 
ATOM   252  O O   . PRO A 1 33  ? 165.193 160.503 183.671 1.00 57.25  ? 58  PRO A O   1 
ATOM   253  C CB  . PRO A 1 33  ? 163.928 159.883 180.669 1.00 57.25  ? 58  PRO A CB  1 
ATOM   254  C CG  . PRO A 1 33  ? 163.497 158.830 179.735 1.00 57.25  ? 58  PRO A CG  1 
ATOM   255  C CD  . PRO A 1 33  ? 162.811 157.803 180.591 1.00 57.25  ? 58  PRO A CD  1 
ATOM   256  N N   . TYR A 1 34  ? 163.002 159.997 183.735 1.00 53.94  ? 59  TYR A N   1 
ATOM   257  C CA  . TYR A 1 34  ? 162.792 160.749 184.968 1.00 53.94  ? 59  TYR A CA  1 
ATOM   258  C C   . TYR A 1 34  ? 163.520 160.103 186.141 1.00 53.94  ? 59  TYR A C   1 
ATOM   259  O O   . TYR A 1 34  ? 164.182 160.793 186.925 1.00 53.94  ? 59  TYR A O   1 
ATOM   260  C CB  . TYR A 1 34  ? 161.297 160.863 185.255 1.00 53.94  ? 59  TYR A CB  1 
ATOM   261  C CG  . TYR A 1 34  ? 160.953 161.538 186.562 1.00 53.94  ? 59  TYR A CG  1 
ATOM   262  C CD1 . TYR A 1 34  ? 160.996 162.919 186.683 1.00 53.94  ? 59  TYR A CD1 1 
ATOM   263  C CD2 . TYR A 1 34  ? 160.570 160.795 187.670 1.00 53.94  ? 59  TYR A CD2 1 
ATOM   264  C CE1 . TYR A 1 34  ? 160.676 163.541 187.873 1.00 53.94  ? 59  TYR A CE1 1 
ATOM   265  C CE2 . TYR A 1 34  ? 160.247 161.407 188.864 1.00 53.94  ? 59  TYR A CE2 1 
ATOM   266  C CZ  . TYR A 1 34  ? 160.303 162.780 188.960 1.00 53.94  ? 59  TYR A CZ  1 
ATOM   267  O OH  . TYR A 1 34  ? 159.983 163.395 190.147 1.00 53.94  ? 59  TYR A OH  1 
ATOM   268  N N   . ILE A 1 35  ? 163.410 158.780 186.277 1.00 55.84  ? 60  ILE A N   1 
ATOM   269  C CA  . ILE A 1 35  ? 164.112 158.082 187.349 1.00 55.84  ? 60  ILE A CA  1 
ATOM   270  C C   . ILE A 1 35  ? 165.618 158.224 187.177 1.00 55.84  ? 60  ILE A C   1 
ATOM   271  O O   . ILE A 1 35  ? 166.364 158.336 188.158 1.00 55.84  ? 60  ILE A O   1 
ATOM   272  C CB  . ILE A 1 35  ? 163.681 156.604 187.395 1.00 55.84  ? 60  ILE A CB  1 
ATOM   273  C CG1 . ILE A 1 35  ? 162.188 156.496 187.703 1.00 55.84  ? 60  ILE A CG1 1 
ATOM   274  C CG2 . ILE A 1 35  ? 164.489 155.838 188.427 1.00 55.84  ? 60  ILE A CG2 1 
ATOM   275  C CD1 . ILE A 1 35  ? 161.706 155.075 187.886 1.00 55.84  ? 60  ILE A CD1 1 
ATOM   276  N N   . ARG A 1 36  ? 166.089 158.240 185.930 1.00 60.32  ? 61  ARG A N   1 
ATOM   277  C CA  . ARG A 1 36  ? 167.522 158.379 185.693 1.00 60.32  ? 61  ARG A CA  1 
ATOM   278  C C   . ARG A 1 36  ? 168.007 159.785 186.029 1.00 60.32  ? 61  ARG A C   1 
ATOM   279  O O   . ARG A 1 36  ? 169.099 159.955 186.582 1.00 60.32  ? 61  ARG A O   1 
ATOM   280  C CB  . ARG A 1 36  ? 167.850 158.028 184.243 1.00 60.32  ? 61  ARG A CB  1 
ATOM   281  C CG  . ARG A 1 36  ? 169.310 158.216 183.871 1.00 60.32  ? 61  ARG A CG  1 
ATOM   282  C CD  . ARG A 1 36  ? 169.759 157.192 182.841 1.00 60.32  ? 61  ARG A CD  1 
ATOM   283  N NE  . ARG A 1 36  ? 168.928 157.208 181.641 1.00 60.32  ? 61  ARG A NE  1 
ATOM   284  C CZ  . ARG A 1 36  ? 168.023 156.281 181.345 1.00 60.32  ? 61  ARG A CZ  1 
ATOM   285  N NH1 . ARG A 1 36  ? 167.826 155.259 182.167 1.00 60.32  ? 61  ARG A NH1 1 
ATOM   286  N NH2 . ARG A 1 36  ? 167.313 156.376 180.230 1.00 60.32  ? 61  ARG A NH2 1 
ATOM   287  N N   . ILE A 1 37  ? 167.208 160.804 185.710 1.00 63.32  ? 62  ILE A N   1 
ATOM   288  C CA  . ILE A 1 37  ? 167.650 162.177 185.921 1.00 63.32  ? 62  ILE A CA  1 
ATOM   289  C C   . ILE A 1 37  ? 167.502 162.591 187.382 1.00 63.32  ? 62  ILE A C   1 
ATOM   290  O O   . ILE A 1 37  ? 168.241 163.460 187.859 1.00 63.32  ? 62  ILE A O   1 
ATOM   291  C CB  . ILE A 1 37  ? 166.890 163.132 184.982 1.00 63.32  ? 62  ILE A CB  1 
ATOM   292  C CG1 . ILE A 1 37  ? 167.571 164.499 184.932 1.00 63.32  ? 62  ILE A CG1 1 
ATOM   293  C CG2 . ILE A 1 37  ? 165.444 163.289 185.413 1.00 63.32  ? 62  ILE A CG2 1 
ATOM   294  C CD1 . ILE A 1 37  ? 166.932 165.451 183.950 1.00 63.32  ? 62  ILE A CD1 1 
ATOM   295  N N   . GLN A 1 38  ? 166.570 161.989 188.117 1.00 58.81  ? 63  GLN A N   1 
ATOM   296  C CA  . GLN A 1 38  ? 166.362 162.345 189.514 1.00 58.81  ? 63  GLN A CA  1 
ATOM   297  C C   . GLN A 1 38  ? 167.276 161.588 190.467 1.00 58.81  ? 63  GLN A C   1 
ATOM   298  O O   . GLN A 1 38  ? 167.174 161.781 191.683 1.00 58.81  ? 63  GLN A O   1 
ATOM   299  C CB  . GLN A 1 38  ? 164.900 162.112 189.909 1.00 58.81  ? 63  GLN A CB  1 
ATOM   300  C CG  . GLN A 1 38  ? 163.918 163.048 189.224 1.00 58.81  ? 63  GLN A CG  1 
ATOM   301  C CD  . GLN A 1 38  ? 163.935 164.449 189.803 1.00 58.81  ? 63  GLN A CD  1 
ATOM   302  O OE1 . GLN A 1 38  ? 164.677 164.739 190.740 1.00 58.81  ? 63  GLN A OE1 1 
ATOM   303  N NE2 . GLN A 1 38  ? 163.114 165.328 189.242 1.00 58.81  ? 63  GLN A NE2 1 
ATOM   304  N N   . GLY A 1 39  ? 168.160 160.735 189.955 1.00 63.80  ? 64  GLY A N   1 
ATOM   305  C CA  . GLY A 1 39  ? 169.089 160.006 190.790 1.00 63.80  ? 64  GLY A CA  1 
ATOM   306  C C   . GLY A 1 39  ? 168.521 158.787 191.482 1.00 63.80  ? 64  GLY A C   1 
ATOM   307  O O   . GLY A 1 39  ? 169.192 158.225 192.356 1.00 63.80  ? 64  GLY A O   1 
ATOM   308  N N   . LEU A 1 40  ? 167.311 158.360 191.126 1.00 63.26  ? 65  LEU A N   1 
ATOM   309  C CA  . LEU A 1 40  ? 166.673 157.206 191.744 1.00 63.26  ? 65  LEU A CA  1 
ATOM   310  C C   . LEU A 1 40  ? 167.004 155.892 191.043 1.00 63.26  ? 65  LEU A C   1 
ATOM   311  O O   . LEU A 1 40  ? 166.234 154.932 191.162 1.00 63.26  ? 65  LEU A O   1 
ATOM   312  C CB  . LEU A 1 40  ? 165.156 157.408 191.785 1.00 63.26  ? 65  LEU A CB  1 
ATOM   313  C CG  . LEU A 1 40  ? 164.672 158.750 192.334 1.00 63.26  ? 65  LEU A CG  1 
ATOM   314  C CD1 . LEU A 1 40  ? 163.156 158.830 192.295 1.00 63.26  ? 65  LEU A CD1 1 
ATOM   315  C CD2 . LEU A 1 40  ? 165.184 158.964 193.746 1.00 63.26  ? 65  LEU A CD2 1 
ATOM   316  N N   . ASP A 1 41  ? 168.123 155.823 190.318 1.00 73.41  ? 66  ASP A N   1 
ATOM   317  C CA  . ASP A 1 41  ? 168.505 154.615 189.584 1.00 73.41  ? 66  ASP A CA  1 
ATOM   318  C C   . ASP A 1 41  ? 169.177 153.624 190.537 1.00 73.41  ? 66  ASP A C   1 
ATOM   319  O O   . ASP A 1 41  ? 170.354 153.279 190.419 1.00 73.41  ? 66  ASP A O   1 
ATOM   320  C CB  . ASP A 1 41  ? 169.406 154.969 188.410 1.00 73.41  ? 66  ASP A CB  1 
ATOM   321  C CG  . ASP A 1 41  ? 170.537 155.897 188.802 1.00 73.41  ? 66  ASP A CG  1 
ATOM   322  O OD1 . ASP A 1 41  ? 171.709 155.470 188.734 1.00 73.41  ? 66  ASP A OD1 1 
ATOM   323  O OD2 . ASP A 1 41  ? 170.256 157.054 189.177 1.00 73.41  ? 66  ASP A OD2 1 
ATOM   324  N N   . VAL A 1 42  ? 168.388 153.162 191.502 1.00 76.02  ? 67  VAL A N   1 
ATOM   325  C CA  . VAL A 1 42  ? 168.810 152.154 192.471 1.00 76.02  ? 67  VAL A CA  1 
ATOM   326  C C   . VAL A 1 42  ? 167.651 151.175 192.617 1.00 76.02  ? 67  VAL A C   1 
ATOM   327  O O   . VAL A 1 42  ? 166.505 151.614 192.771 1.00 76.02  ? 67  VAL A O   1 
ATOM   328  C CB  . VAL A 1 42  ? 169.198 152.796 193.814 1.00 76.02  ? 67  VAL A CB  1 
ATOM   329  C CG1 . VAL A 1 42  ? 169.177 151.769 194.935 1.00 76.02  ? 67  VAL A CG1 1 
ATOM   330  C CG2 . VAL A 1 42  ? 170.570 153.448 193.712 1.00 76.02  ? 67  VAL A CG2 1 
ATOM   331  N N   . PRO A 1 43  ? 167.897 149.858 192.581 1.00 78.65  ? 68  PRO A N   1 
ATOM   332  C CA  . PRO A 1 43  ? 166.778 148.897 192.477 1.00 78.65  ? 68  PRO A CA  1 
ATOM   333  C C   . PRO A 1 43  ? 165.662 149.083 193.496 1.00 78.65  ? 68  PRO A C   1 
ATOM   334  O O   . PRO A 1 43  ? 164.483 149.116 193.115 1.00 78.65  ? 68  PRO A O   1 
ATOM   335  C CB  . PRO A 1 43  ? 167.479 147.537 192.643 1.00 78.65  ? 68  PRO A CB  1 
ATOM   336  C CG  . PRO A 1 43  ? 168.873 147.845 193.127 1.00 78.65  ? 68  PRO A CG  1 
ATOM   337  C CD  . PRO A 1 43  ? 169.202 149.182 192.566 1.00 78.65  ? 68  PRO A CD  1 
ATOM   338  N N   . LYS A 1 44  ? 165.993 149.207 194.783 1.00 74.64  ? 69  LYS A N   1 
ATOM   339  C CA  . LYS A 1 44  ? 164.944 149.342 195.789 1.00 74.64  ? 69  LYS A CA  1 
ATOM   340  C C   . LYS A 1 44  ? 164.181 150.650 195.623 1.00 74.64  ? 69  LYS A C   1 
ATOM   341  O O   . LYS A 1 44  ? 162.956 150.683 195.787 1.00 74.64  ? 69  LYS A O   1 
ATOM   342  C CB  . LYS A 1 44  ? 165.535 149.239 197.194 1.00 74.64  ? 69  LYS A CB  1 
ATOM   343  C CG  . LYS A 1 44  ? 164.482 149.243 198.290 1.00 74.64  ? 69  LYS A CG  1 
ATOM   344  C CD  . LYS A 1 44  ? 165.018 148.673 199.590 1.00 74.64  ? 69  LYS A CD  1 
ATOM   345  C CE  . LYS A 1 44  ? 163.909 148.524 200.619 1.00 74.64  ? 69  LYS A CE  1 
ATOM   346  N NZ  . LYS A 1 44  ? 164.398 147.898 201.877 1.00 74.64  ? 69  LYS A NZ  1 
ATOM   347  N N   . LEU A 1 45  ? 164.884 151.736 195.297 1.00 71.80  ? 70  LEU A N   1 
ATOM   348  C CA  . LEU A 1 45  ? 164.208 153.012 195.080 1.00 71.80  ? 70  LEU A CA  1 
ATOM   349  C C   . LEU A 1 45  ? 163.289 152.950 193.867 1.00 71.80  ? 70  LEU A C   1 
ATOM   350  O O   . LEU A 1 45  ? 162.199 153.533 193.875 1.00 71.80  ? 70  LEU A O   1 
ATOM   351  C CB  . LEU A 1 45  ? 165.237 154.131 194.920 1.00 71.80  ? 70  LEU A CB  1 
ATOM   352  C CG  . LEU A 1 45  ? 165.789 154.749 196.206 1.00 71.80  ? 70  LEU A CG  1 
ATOM   353  C CD1 . LEU A 1 45  ? 166.843 153.856 196.838 1.00 71.80  ? 70  LEU A CD1 1 
ATOM   354  C CD2 . LEU A 1 45  ? 166.355 156.133 195.934 1.00 71.80  ? 70  LEU A CD2 1 
ATOM   355  N N   . ARG A 1 46  ? 163.710 152.244 192.816 1.00 72.40  ? 71  ARG A N   1 
ATOM   356  C CA  . ARG A 1 46  ? 162.865 152.088 191.639 1.00 72.40  ? 71  ARG A CA  1 
ATOM   357  C C   . ARG A 1 46  ? 161.687 151.166 191.918 1.00 72.40  ? 71  ARG A C   1 
ATOM   358  O O   . ARG A 1 46  ? 160.664 151.242 191.228 1.00 72.40  ? 71  ARG A O   1 
ATOM   359  C CB  . ARG A 1 46  ? 163.689 151.556 190.467 1.00 72.40  ? 71  ARG A CB  1 
ATOM   360  C CG  . ARG A 1 46  ? 163.088 151.851 189.103 1.00 72.40  ? 71  ARG A CG  1 
ATOM   361  C CD  . ARG A 1 46  ? 163.867 151.166 187.993 1.00 72.40  ? 71  ARG A CD  1 
ATOM   362  N NE  . ARG A 1 46  ? 163.612 151.775 186.690 1.00 72.40  ? 71  ARG A NE  1 
ATOM   363  C CZ  . ARG A 1 46  ? 162.534 151.536 185.949 1.00 72.40  ? 71  ARG A CZ  1 
ATOM   364  N NH1 . ARG A 1 46  ? 161.602 150.698 186.380 1.00 72.40  ? 71  ARG A NH1 1 
ATOM   365  N NH2 . ARG A 1 46  ? 162.388 152.136 184.776 1.00 72.40  ? 71  ARG A NH2 1 
ATOM   366  N N   . GLU A 1 47  ? 161.813 150.291 192.917 1.00 75.31  ? 72  GLU A N   1 
ATOM   367  C CA  . GLU A 1 47  ? 160.708 149.402 193.261 1.00 75.31  ? 72  GLU A CA  1 
ATOM   368  C C   . GLU A 1 47  ? 159.524 150.167 193.841 1.00 75.31  ? 72  GLU A C   1 
ATOM   369  O O   . GLU A 1 47  ? 158.378 149.726 193.703 1.00 75.31  ? 72  GLU A O   1 
ATOM   370  C CB  . GLU A 1 47  ? 161.186 148.333 194.243 1.00 75.31  ? 72  GLU A CB  1 
ATOM   371  C CG  . GLU A 1 47  ? 160.219 147.174 194.428 1.00 75.31  ? 72  GLU A CG  1 
ATOM   372  C CD  . GLU A 1 47  ? 159.224 147.416 195.546 1.00 75.31  ? 72  GLU A CD  1 
ATOM   373  O OE1 . GLU A 1 47  ? 159.569 148.141 196.502 1.00 75.31  ? 72  GLU A OE1 1 
ATOM   374  O OE2 . GLU A 1 47  ? 158.096 146.886 195.466 1.00 75.31  ? 72  GLU A OE2 1 
ATOM   375  N N   . HIS A 1 48  ? 159.773 151.308 194.484 1.00 74.15  ? 73  HIS A N   1 
ATOM   376  C CA  . HIS A 1 48  ? 158.710 152.054 195.145 1.00 74.15  ? 73  HIS A CA  1 
ATOM   377  C C   . HIS A 1 48  ? 157.930 152.962 194.203 1.00 74.15  ? 73  HIS A C   1 
ATOM   378  O O   . HIS A 1 48  ? 156.945 153.570 194.635 1.00 74.15  ? 73  HIS A O   1 
ATOM   379  C CB  . HIS A 1 48  ? 159.288 152.885 196.292 1.00 74.15  ? 73  HIS A CB  1 
ATOM   380  C CG  . HIS A 1 48  ? 159.795 152.062 197.435 1.00 74.15  ? 73  HIS A CG  1 
ATOM   381  N ND1 . HIS A 1 48  ? 158.955 151.393 198.299 1.00 74.15  ? 73  HIS A ND1 1 
ATOM   382  C CD2 . HIS A 1 48  ? 161.054 151.799 197.856 1.00 74.15  ? 73  HIS A CD2 1 
ATOM   383  C CE1 . HIS A 1 48  ? 159.676 150.752 199.202 1.00 74.15  ? 73  HIS A CE1 1 
ATOM   384  N NE2 . HIS A 1 48  ? 160.953 150.982 198.955 1.00 74.15  ? 73  HIS A NE2 1 
ATOM   385  N N   . CYS A 1 49  ? 158.338 153.073 192.938 1.00 72.86  ? 74  CYS A N   1 
ATOM   386  C CA  . CYS A 1 49  ? 157.628 153.903 191.964 1.00 72.86  ? 74  CYS A CA  1 
ATOM   387  C C   . CYS A 1 49  ? 156.407 153.140 191.459 1.00 72.86  ? 74  CYS A C   1 
ATOM   388  O O   . CYS A 1 49  ? 156.391 152.568 190.366 1.00 72.86  ? 74  CYS A O   1 
ATOM   389  C CB  . CYS A 1 49  ? 158.551 154.302 190.821 1.00 72.86  ? 74  CYS A CB  1 
ATOM   390  S SG  . CYS A 1 49  ? 159.654 155.683 191.188 1.00 72.86  ? 74  CYS A SG  1 
ATOM   391  N N   . ARG A 1 50  ? 155.358 153.141 192.278 1.00 71.44  ? 75  ARG A N   1 
ATOM   392  C CA  . ARG A 1 50  ? 154.102 152.492 191.937 1.00 71.44  ? 75  ARG A CA  1 
ATOM   393  C C   . ARG A 1 50  ? 152.969 153.504 192.004 1.00 71.44  ? 75  ARG A C   1 
ATOM   394  O O   . ARG A 1 50  ? 152.960 154.397 192.855 1.00 71.44  ? 75  ARG A O   1 
ATOM   395  C CB  . ARG A 1 50  ? 153.803 151.312 192.871 1.00 71.44  ? 75  ARG A CB  1 
ATOM   396  C CG  . ARG A 1 50  ? 155.012 150.448 193.185 1.00 71.44  ? 75  ARG A CG  1 
ATOM   397  C CD  . ARG A 1 50  ? 154.657 148.972 193.156 1.00 71.44  ? 75  ARG A CD  1 
ATOM   398  N NE  . ARG A 1 50  ? 154.345 148.512 191.806 1.00 71.44  ? 75  ARG A NE  1 
ATOM   399  C CZ  . ARG A 1 50  ? 155.254 148.099 190.930 1.00 71.44  ? 75  ARG A CZ  1 
ATOM   400  N NH1 . ARG A 1 50  ? 154.880 147.697 189.723 1.00 71.44  ? 75  ARG A NH1 1 
ATOM   401  N NH2 . ARG A 1 50  ? 156.538 148.088 191.259 1.00 71.44  ? 75  ARG A NH2 1 
ATOM   402  N N   . GLU A 1 51  ? 152.012 153.352 191.094 1.00 65.52  ? 76  GLU A N   1 
ATOM   403  C CA  . GLU A 1 51  ? 150.881 154.266 191.034 1.00 65.52  ? 76  GLU A CA  1 
ATOM   404  C C   . GLU A 1 51  ? 149.998 154.115 192.266 1.00 65.52  ? 76  GLU A C   1 
ATOM   405  O O   . GLU A 1 51  ? 149.703 153.002 192.707 1.00 65.52  ? 76  GLU A O   1 
ATOM   406  C CB  . GLU A 1 51  ? 150.062 154.007 189.769 1.00 65.52  ? 76  GLU A CB  1 
ATOM   407  C CG  . GLU A 1 51  ? 148.707 154.693 189.749 1.00 65.52  ? 76  GLU A CG  1 
ATOM   408  C CD  . GLU A 1 51  ? 147.765 154.091 188.726 1.00 65.52  ? 76  GLU A CD  1 
ATOM   409  O OE1 . GLU A 1 51  ? 148.187 153.169 187.997 1.00 65.52  ? 76  GLU A OE1 1 
ATOM   410  O OE2 . GLU A 1 51  ? 146.600 154.536 188.653 1.00 65.52  ? 76  GLU A OE2 1 
ATOM   411  N N   . ARG A 1 52  ? 149.576 155.255 192.828 1.00 67.82  ? 77  ARG A N   1 
ATOM   412  C CA  . ARG A 1 52  ? 148.647 155.183 193.943 1.00 67.82  ? 77  ARG A CA  1 
ATOM   413  C C   . ARG A 1 52  ? 147.214 155.063 193.432 1.00 67.82  ? 77  ARG A C   1 
ATOM   414  O O   . ARG A 1 52  ? 146.889 155.567 192.353 1.00 67.82  ? 77  ARG A O   1 
ATOM   415  C CB  . ARG A 1 52  ? 148.777 156.421 194.827 1.00 67.82  ? 77  ARG A CB  1 
ATOM   416  C CG  . ARG A 1 52  ? 148.398 157.722 194.143 1.00 67.82  ? 77  ARG A CG  1 
ATOM   417  C CD  . ARG A 1 52  ? 148.628 158.910 195.060 1.00 67.82  ? 77  ARG A CD  1 
ATOM   418  N NE  . ARG A 1 52  ? 150.036 159.057 195.417 1.00 67.82  ? 77  ARG A NE  1 
ATOM   419  C CZ  . ARG A 1 52  ? 150.502 159.973 196.258 1.00 67.82  ? 77  ARG A CZ  1 
ATOM   420  N NH1 . ARG A 1 52  ? 149.671 160.830 196.835 1.00 67.82  ? 77  ARG A NH1 1 
ATOM   421  N NH2 . ARG A 1 52  ? 151.799 160.033 196.523 1.00 67.82  ? 77  ARG A NH2 1 
ATOM   422  N N   . PRO A 1 53  ? 146.342 154.388 194.180 1.00 68.54  ? 78  PRO A N   1 
ATOM   423  C CA  . PRO A 1 53  ? 144.962 154.208 193.714 1.00 68.54  ? 78  PRO A CA  1 
ATOM   424  C C   . PRO A 1 53  ? 144.221 155.534 193.627 1.00 68.54  ? 78  PRO A C   1 
ATOM   425  O O   . PRO A 1 53  ? 144.381 156.416 194.474 1.00 68.54  ? 78  PRO A O   1 
ATOM   426  C CB  . PRO A 1 53  ? 144.344 153.289 194.776 1.00 68.54  ? 78  PRO A CB  1 
ATOM   427  C CG  . PRO A 1 53  ? 145.509 152.635 195.448 1.00 68.54  ? 78  PRO A CG  1 
ATOM   428  C CD  . PRO A 1 53  ? 146.605 153.652 195.427 1.00 68.54  ? 78  PRO A CD  1 
ATOM   429  N N   . GLY A 1 54  ? 143.404 155.667 192.586 1.00 68.92  ? 79  GLY A N   1 
ATOM   430  C CA  . GLY A 1 54  ? 142.595 156.851 192.392 1.00 68.92  ? 79  GLY A CA  1 
ATOM   431  C C   . GLY A 1 54  ? 143.272 157.997 191.675 1.00 68.92  ? 79  GLY A C   1 
ATOM   432  O O   . GLY A 1 54  ? 142.714 159.100 191.647 1.00 68.92  ? 79  GLY A O   1 
ATOM   433  N N   . ALA A 1 55  ? 144.452 157.778 191.093 1.00 61.98  ? 80  ALA A N   1 
ATOM   434  C CA  . ALA A 1 55  ? 145.137 158.855 190.389 1.00 61.98  ? 80  ALA A CA  1 
ATOM   435  C C   . ALA A 1 55  ? 144.528 159.105 189.014 1.00 61.98  ? 80  ALA A C   1 
ATOM   436  O O   . ALA A 1 55  ? 144.341 160.260 188.617 1.00 61.98  ? 80  ALA A O   1 
ATOM   437  C CB  . ALA A 1 55  ? 146.627 158.537 190.261 1.00 61.98  ? 80  ALA A CB  1 
ATOM   438  N N   . PHE A 1 56  ? 144.217 158.045 188.282 1.00 54.61  ? 81  PHE A N   1 
ATOM   439  C CA  . PHE A 1 56  ? 143.652 158.117 186.945 1.00 54.61  ? 81  PHE A CA  1 
ATOM   440  C C   . PHE A 1 56  ? 142.474 157.162 186.852 1.00 54.61  ? 81  PHE A C   1 
ATOM   441  O O   . PHE A 1 56  ? 142.383 156.201 187.623 1.00 54.61  ? 81  PHE A O   1 
ATOM   442  C CB  . PHE A 1 56  ? 144.708 157.765 185.886 1.00 54.61  ? 81  PHE A CB  1 
ATOM   443  C CG  . PHE A 1 56  ? 145.836 158.753 185.805 1.00 54.61  ? 81  PHE A CG  1 
ATOM   444  C CD1 . PHE A 1 56  ? 146.937 158.637 186.635 1.00 54.61  ? 81  PHE A CD1 1 
ATOM   445  C CD2 . PHE A 1 56  ? 145.794 159.799 184.900 1.00 54.61  ? 81  PHE A CD2 1 
ATOM   446  C CE1 . PHE A 1 56  ? 147.974 159.546 186.564 1.00 54.61  ? 81  PHE A CE1 1 
ATOM   447  C CE2 . PHE A 1 56  ? 146.830 160.710 184.824 1.00 54.61  ? 81  PHE A CE2 1 
ATOM   448  C CZ  . PHE A 1 56  ? 147.921 160.582 185.656 1.00 54.61  ? 81  PHE A CZ  1 
ATOM   449  N N   . PRO A 1 57  ? 141.542 157.408 185.929 1.00 50.50  ? 82  PRO A N   1 
ATOM   450  C CA  . PRO A 1 57  ? 140.362 156.541 185.826 1.00 50.50  ? 82  PRO A CA  1 
ATOM   451  C C   . PRO A 1 57  ? 140.737 155.097 185.521 1.00 50.50  ? 82  PRO A C   1 
ATOM   452  O O   . PRO A 1 57  ? 141.825 154.795 185.025 1.00 50.50  ? 82  PRO A O   1 
ATOM   453  C CB  . PRO A 1 57  ? 139.562 157.163 184.677 1.00 50.50  ? 82  PRO A CB  1 
ATOM   454  C CG  . PRO A 1 57  ? 139.995 158.585 184.650 1.00 50.50  ? 82  PRO A CG  1 
ATOM   455  C CD  . PRO A 1 57  ? 141.444 158.573 185.034 1.00 50.50  ? 82  PRO A CD  1 
ATOM   456  N N   . SER A 1 58  ? 139.807 154.199 185.823 1.00 58.13  ? 83  SER A N   1 
ATOM   457  C CA  . SER A 1 58  ? 140.044 152.767 185.743 1.00 58.13  ? 83  SER A CA  1 
ATOM   458  C C   . SER A 1 58  ? 139.626 152.207 184.388 1.00 58.13  ? 83  SER A C   1 
ATOM   459  O O   . SER A 1 58  ? 138.796 152.778 183.673 1.00 58.13  ? 83  SER A O   1 
ATOM   460  C CB  . SER A 1 58  ? 139.299 152.034 186.862 1.00 58.13  ? 83  SER A CB  1 
ATOM   461  O OG  . SER A 1 58  ? 139.485 152.687 188.105 1.00 58.13  ? 83  SER A OG  1 
ATOM   462  N N   . GLU A 1 59  ? 140.217 151.057 184.051 1.00 66.22  ? 84  GLU A N   1 
ATOM   463  C CA  . GLU A 1 59  ? 139.931 150.417 182.773 1.00 66.22  ? 84  GLU A CA  1 
ATOM   464  C C   . GLU A 1 59  ? 138.460 150.038 182.664 1.00 66.22  ? 84  GLU A C   1 
ATOM   465  O O   . GLU A 1 59  ? 137.871 150.118 181.581 1.00 66.22  ? 84  GLU A O   1 
ATOM   466  C CB  . GLU A 1 59  ? 140.816 149.187 182.590 1.00 66.22  ? 84  GLU A CB  1 
ATOM   467  C CG  . GLU A 1 59  ? 142.299 149.455 182.782 1.00 66.22  ? 84  GLU A CG  1 
ATOM   468  C CD  . GLU A 1 59  ? 143.163 148.273 182.390 1.00 66.22  ? 84  GLU A CD  1 
ATOM   469  O OE1 . GLU A 1 59  ? 142.663 147.380 181.674 1.00 66.22  ? 84  GLU A OE1 1 
ATOM   470  O OE2 . GLU A 1 59  ? 144.342 148.237 182.799 1.00 66.22  ? 84  GLU A OE2 1 
ATOM   471  N N   . GLU A 1 60  ? 137.846 149.629 183.776 1.00 64.55  ? 85  GLU A N   1 
ATOM   472  C CA  . GLU A 1 60  ? 136.425 149.301 183.749 1.00 64.55  ? 85  GLU A CA  1 
ATOM   473  C C   . GLU A 1 60  ? 135.584 150.528 183.419 1.00 64.55  ? 85  GLU A C   1 
ATOM   474  O O   . GLU A 1 60  ? 134.622 150.441 182.646 1.00 64.55  ? 85  GLU A O   1 
ATOM   475  C CB  . GLU A 1 60  ? 135.997 148.700 185.088 1.00 64.55  ? 85  GLU A CB  1 
ATOM   476  C CG  . GLU A 1 60  ? 134.525 148.334 185.162 1.00 64.55  ? 85  GLU A CG  1 
ATOM   477  C CD  . GLU A 1 60  ? 134.087 147.437 184.022 1.00 64.55  ? 85  GLU A CD  1 
ATOM   478  O OE1 . GLU A 1 60  ? 133.362 147.920 183.128 1.00 64.55  ? 85  GLU A OE1 1 
ATOM   479  O OE2 . GLU A 1 60  ? 134.467 146.247 184.021 1.00 64.55  ? 85  GLU A OE2 1 
ATOM   480  N N   . THR A 1 61  ? 135.937 151.684 183.984 1.00 60.45  ? 86  THR A N   1 
ATOM   481  C CA  . THR A 1 61  ? 135.201 152.906 183.676 1.00 60.45  ? 86  THR A CA  1 
ATOM   482  C C   . THR A 1 61  ? 135.413 153.332 182.228 1.00 60.45  ? 86  THR A C   1 
ATOM   483  O O   . THR A 1 61  ? 134.470 153.785 181.566 1.00 60.45  ? 86  THR A O   1 
ATOM   484  C CB  . THR A 1 61  ? 135.614 154.027 184.629 1.00 60.45  ? 86  THR A CB  1 
ATOM   485  O OG1 . THR A 1 61  ? 137.032 153.990 184.828 1.00 60.45  ? 86  THR A OG1 1 
ATOM   486  C CG2 . THR A 1 61  ? 134.910 153.872 185.968 1.00 60.45  ? 86  THR A CG2 1 
ATOM   487  N N   . LEU A 1 62  ? 136.639 153.195 181.715 1.00 54.87  ? 87  LEU A N   1 
ATOM   488  C CA  . LEU A 1 62  ? 136.877 153.516 180.309 1.00 54.87  ? 87  LEU A CA  1 
ATOM   489  C C   . LEU A 1 62  ? 136.100 152.584 179.386 1.00 54.87  ? 87  LEU A C   1 
ATOM   490  O O   . LEU A 1 62  ? 135.613 153.010 178.332 1.00 54.87  ? 87  LEU A O   1 
ATOM   491  C CB  . LEU A 1 62  ? 138.372 153.469 179.988 1.00 54.87  ? 87  LEU A CB  1 
ATOM   492  C CG  . LEU A 1 62  ? 139.181 154.756 180.189 1.00 54.87  ? 87  LEU A CG  1 
ATOM   493  C CD1 . LEU A 1 62  ? 139.355 155.102 181.652 1.00 54.87  ? 87  LEU A CD1 1 
ATOM   494  C CD2 . LEU A 1 62  ? 140.533 154.634 179.509 1.00 54.87  ? 87  LEU A CD2 1 
ATOM   495  N N   . ARG A 1 63  ? 135.972 151.309 179.760 1.00 62.92  ? 88  ARG A N   1 
ATOM   496  C CA  . ARG A 1 63  ? 135.169 150.390 178.960 1.00 62.92  ? 88  ARG A CA  1 
ATOM   497  C C   . ARG A 1 63  ? 133.691 150.750 179.027 1.00 62.92  ? 88  ARG A C   1 
ATOM   498  O O   . ARG A 1 63  ? 132.983 150.682 178.016 1.00 62.92  ? 88  ARG A O   1 
ATOM   499  C CB  . ARG A 1 63  ? 135.383 148.949 179.425 1.00 62.92  ? 88  ARG A CB  1 
ATOM   500  C CG  . ARG A 1 63  ? 136.795 148.421 179.240 1.00 62.92  ? 88  ARG A CG  1 
ATOM   501  C CD  . ARG A 1 63  ? 137.261 148.537 177.801 1.00 62.92  ? 88  ARG A CD  1 
ATOM   502  N NE  . ARG A 1 63  ? 138.345 147.605 177.507 1.00 62.92  ? 88  ARG A NE  1 
ATOM   503  C CZ  . ARG A 1 63  ? 139.606 147.777 177.892 1.00 62.92  ? 88  ARG A CZ  1 
ATOM   504  N NH1 . ARG A 1 63  ? 140.525 146.874 177.576 1.00 62.92  ? 88  ARG A NH1 1 
ATOM   505  N NH2 . ARG A 1 63  ? 139.951 148.849 178.591 1.00 62.92  ? 88  ARG A NH2 1 
ATOM   506  N N   . GLY A 1 64  ? 133.205 151.130 180.210 1.00 62.83  ? 89  GLY A N   1 
ATOM   507  C CA  . GLY A 1 64  ? 131.803 151.479 180.348 1.00 62.83  ? 89  GLY A CA  1 
ATOM   508  C C   . GLY A 1 64  ? 131.433 152.770 179.648 1.00 62.83  ? 89  GLY A C   1 
ATOM   509  O O   . GLY A 1 64  ? 130.289 152.936 179.214 1.00 62.83  ? 89  GLY A O   1 
ATOM   510  N N   . LEU A 1 65  ? 132.380 153.696 179.532 1.00 63.78  ? 90  LEU A N   1 
ATOM   511  C CA  . LEU A 1 65  ? 132.111 154.960 178.861 1.00 63.78  ? 90  LEU A CA  1 
ATOM   512  C C   . LEU A 1 65  ? 131.805 154.737 177.384 1.00 63.78  ? 90  LEU A C   1 
ATOM   513  O O   . LEU A 1 65  ? 132.278 153.782 176.763 1.00 63.78  ? 90  LEU A O   1 
ATOM   514  C CB  . LEU A 1 65  ? 133.298 155.910 179.013 1.00 63.78  ? 90  LEU A CB  1 
ATOM   515  C CG  . LEU A 1 65  ? 133.173 156.955 180.122 1.00 63.78  ? 90  LEU A CG  1 
ATOM   516  C CD1 . LEU A 1 65  ? 134.467 157.735 180.276 1.00 63.78  ? 90  LEU A CD1 1 
ATOM   517  C CD2 . LEU A 1 65  ? 132.011 157.891 179.837 1.00 63.78  ? 90  LEU A CD2 1 
ATOM   518  N N   . GLY A 1 66  ? 131.004 155.640 176.821 1.00 68.30  ? 91  GLY A N   1 
ATOM   519  C CA  . GLY A 1 66  ? 130.586 155.529 175.436 1.00 68.30  ? 91  GLY A CA  1 
ATOM   520  C C   . GLY A 1 66  ? 131.579 156.113 174.453 1.00 68.30  ? 91  GLY A C   1 
ATOM   521  O O   . GLY A 1 66  ? 132.769 155.787 174.494 1.00 68.30  ? 91  GLY A O   1 
ATOM   522  N N   . ARG A 1 67  ? 131.100 156.978 173.557 1.00 77.49  ? 92  ARG A N   1 
ATOM   523  C CA  . ARG A 1 67  ? 131.944 157.587 172.541 1.00 77.49  ? 92  ARG A CA  1 
ATOM   524  C C   . ARG A 1 67  ? 132.063 159.100 172.657 1.00 77.49  ? 92  ARG A C   1 
ATOM   525  O O   . ARG A 1 67  ? 132.873 159.692 171.935 1.00 77.49  ? 92  ARG A O   1 
ATOM   526  C CB  . ARG A 1 67  ? 131.430 157.234 171.135 1.00 77.49  ? 92  ARG A CB  1 
ATOM   527  C CG  . ARG A 1 67  ? 131.253 155.742 170.895 1.00 77.49  ? 92  ARG A CG  1 
ATOM   528  C CD  . ARG A 1 67  ? 130.696 155.465 169.506 1.00 77.49  ? 92  ARG A CD  1 
ATOM   529  N NE  . ARG A 1 67  ? 131.665 155.769 168.457 1.00 77.49  ? 92  ARG A NE  1 
ATOM   530  C CZ  . ARG A 1 67  ? 131.434 155.611 167.158 1.00 77.49  ? 92  ARG A CZ  1 
ATOM   531  N NH1 . ARG A 1 67  ? 132.374 155.912 166.274 1.00 77.49  ? 92  ARG A NH1 1 
ATOM   532  N NH2 . ARG A 1 67  ? 130.261 155.154 166.742 1.00 77.49  ? 92  ARG A NH2 1 
ATOM   533  N N   . ARG A 1 68  ? 131.286 159.743 173.527 1.00 74.52  ? 93  ARG A N   1 
ATOM   534  C CA  . ARG A 1 68  ? 131.362 161.184 173.734 1.00 74.52  ? 93  ARG A CA  1 
ATOM   535  C C   . ARG A 1 68  ? 131.919 161.550 175.100 1.00 74.52  ? 93  ARG A C   1 
ATOM   536  O O   . ARG A 1 68  ? 132.885 162.321 175.196 1.00 74.52  ? 93  ARG A O   1 
ATOM   537  C CB  . ARG A 1 68  ? 129.971 161.810 173.550 1.00 74.52  ? 93  ARG A CB  1 
ATOM   538  C CG  . ARG A 1 68  ? 129.404 161.647 172.148 1.00 74.52  ? 93  ARG A CG  1 
ATOM   539  C CD  . ARG A 1 68  ? 127.968 162.142 172.063 1.00 74.52  ? 93  ARG A CD  1 
ATOM   540  N NE  . ARG A 1 68  ? 127.060 161.334 172.874 1.00 74.52  ? 93  ARG A NE  1 
ATOM   541  C CZ  . ARG A 1 68  ? 125.740 161.484 172.892 1.00 74.52  ? 93  ARG A CZ  1 
ATOM   542  N NH1 . ARG A 1 68  ? 124.992 160.705 173.661 1.00 74.52  ? 93  ARG A NH1 1 
ATOM   543  N NH2 . ARG A 1 68  ? 125.166 162.414 172.140 1.00 74.52  ? 93  ARG A NH2 1 
ATOM   544  N N   . GLY A 1 69  ? 131.326 161.016 176.170 1.00 65.73  ? 94  GLY A N   1 
ATOM   545  C CA  . GLY A 1 69  ? 131.886 161.224 177.492 1.00 65.73  ? 94  GLY A CA  1 
ATOM   546  C C   . GLY A 1 69  ? 133.293 160.682 177.617 1.00 65.73  ? 94  GLY A C   1 
ATOM   547  O O   . GLY A 1 69  ? 134.107 161.224 178.367 1.00 65.73  ? 94  GLY A O   1 
ATOM   548  N N   . PHE A 1 70  ? 133.603 159.616 176.876 1.00 58.57  ? 95  PHE A N   1 
ATOM   549  C CA  . PHE A 1 70  ? 134.963 159.091 176.859 1.00 58.57  ? 95  PHE A CA  1 
ATOM   550  C C   . PHE A 1 70  ? 135.944 160.137 176.344 1.00 58.57  ? 95  PHE A C   1 
ATOM   551  O O   . PHE A 1 70  ? 136.975 160.404 176.974 1.00 58.57  ? 95  PHE A O   1 
ATOM   552  C CB  . PHE A 1 70  ? 135.016 157.824 176.005 1.00 58.57  ? 95  PHE A CB  1 
ATOM   553  C CG  . PHE A 1 70  ? 136.403 157.293 175.789 1.00 58.57  ? 95  PHE A CG  1 
ATOM   554  C CD1 . PHE A 1 70  ? 137.115 156.735 176.835 1.00 58.57  ? 95  PHE A CD1 1 
ATOM   555  C CD2 . PHE A 1 70  ? 136.989 157.340 174.537 1.00 58.57  ? 95  PHE A CD2 1 
ATOM   556  C CE1 . PHE A 1 70  ? 138.390 156.243 176.638 1.00 58.57  ? 95  PHE A CE1 1 
ATOM   557  C CE2 . PHE A 1 70  ? 138.262 156.849 174.335 1.00 58.57  ? 95  PHE A CE2 1 
ATOM   558  C CZ  . PHE A 1 70  ? 138.963 156.300 175.386 1.00 58.57  ? 95  PHE A CZ  1 
ATOM   559  N N   . LEU A 1 71  ? 135.628 160.752 175.202 1.00 57.64  ? 96  LEU A N   1 
ATOM   560  C CA  . LEU A 1 71  ? 136.498 161.786 174.653 1.00 57.64  ? 96  LEU A CA  1 
ATOM   561  C C   . LEU A 1 71  ? 136.578 162.992 175.580 1.00 57.64  ? 96  LEU A C   1 
ATOM   562  O O   . LEU A 1 71  ? 137.643 163.605 175.724 1.00 57.64  ? 96  LEU A O   1 
ATOM   563  C CB  . LEU A 1 71  ? 136.004 162.204 173.268 1.00 57.64  ? 96  LEU A CB  1 
ATOM   564  C CG  . LEU A 1 71  ? 136.073 161.134 172.176 1.00 57.64  ? 96  LEU A CG  1 
ATOM   565  C CD1 . LEU A 1 71  ? 135.382 161.612 170.912 1.00 57.64  ? 96  LEU A CD1 1 
ATOM   566  C CD2 . LEU A 1 71  ? 137.517 160.758 171.887 1.00 57.64  ? 96  LEU A CD2 1 
ATOM   567  N N   . GLN A 1 72  ? 135.465 163.343 176.228 1.00 59.64  ? 97  GLN A N   1 
ATOM   568  C CA  . GLN A 1 72  ? 135.479 164.489 177.136 1.00 59.64  ? 97  GLN A CA  1 
ATOM   569  C C   . GLN A 1 72  ? 136.386 164.238 178.339 1.00 59.64  ? 97  GLN A C   1 
ATOM   570  O O   . GLN A 1 72  ? 137.202 165.098 178.702 1.00 59.64  ? 97  GLN A O   1 
ATOM   571  C CB  . GLN A 1 72  ? 134.057 164.817 177.587 1.00 59.64  ? 97  GLN A CB  1 
ATOM   572  C CG  . GLN A 1 72  ? 133.150 165.271 176.457 1.00 59.64  ? 97  GLN A CG  1 
ATOM   573  C CD  . GLN A 1 72  ? 131.696 165.353 176.871 1.00 59.64  ? 97  GLN A CD  1 
ATOM   574  O OE1 . GLN A 1 72  ? 131.346 165.059 178.014 1.00 59.64  ? 97  GLN A OE1 1 
ATOM   575  N NE2 . GLN A 1 72  ? 130.837 165.753 175.941 1.00 59.64  ? 97  GLN A NE2 1 
ATOM   576  N N   . THR A 1 73  ? 136.258 163.067 178.970 1.00 53.46  ? 98  THR A N   1 
ATOM   577  C CA  . THR A 1 73  ? 137.120 162.743 180.101 1.00 53.46  ? 98  THR A CA  1 
ATOM   578  C C   . THR A 1 73  ? 138.574 162.627 179.667 1.00 53.46  ? 98  THR A C   1 
ATOM   579  O O   . THR A 1 73  ? 139.483 162.995 180.421 1.00 53.46  ? 98  THR A O   1 
ATOM   580  C CB  . THR A 1 73  ? 136.662 161.449 180.772 1.00 53.46  ? 98  THR A CB  1 
ATOM   581  O OG1 . THR A 1 73  ? 136.758 160.364 179.842 1.00 53.46  ? 98  THR A OG1 1 
ATOM   582  C CG2 . THR A 1 73  ? 135.231 161.579 181.270 1.00 53.46  ? 98  THR A CG2 1 
ATOM   583  N N   . LEU A 1 74  ? 138.818 162.124 178.454 1.00 52.59  ? 99  LEU A N   1 
ATOM   584  C CA  . LEU A 1 74  ? 140.183 162.069 177.945 1.00 52.59  ? 99  LEU A CA  1 
ATOM   585  C C   . LEU A 1 74  ? 140.769 163.468 177.796 1.00 52.59  ? 99  LEU A C   1 
ATOM   586  O O   . LEU A 1 74  ? 141.920 163.712 178.178 1.00 52.59  ? 99  LEU A O   1 
ATOM   587  C CB  . LEU A 1 74  ? 140.211 161.325 176.612 1.00 52.59  ? 99  LEU A CB  1 
ATOM   588  C CG  . LEU A 1 74  ? 141.579 161.047 175.991 1.00 52.59  ? 99  LEU A CG  1 
ATOM   589  C CD1 . LEU A 1 74  ? 142.580 160.613 177.047 1.00 52.59  ? 99  LEU A CD1 1 
ATOM   590  C CD2 . LEU A 1 74  ? 141.452 159.992 174.907 1.00 52.59  ? 99  LEU A CD2 1 
ATOM   591  N N   . ASN A 1 75  ? 139.985 164.400 177.253 1.00 56.02  ? 100 ASN A N   1 
ATOM   592  C CA  . ASN A 1 75  ? 140.439 165.781 177.113 1.00 56.02  ? 100 ASN A CA  1 
ATOM   593  C C   . ASN A 1 75  ? 140.744 166.399 178.474 1.00 56.02  ? 100 ASN A C   1 
ATOM   594  O O   . ASN A 1 75  ? 141.777 167.058 178.656 1.00 56.02  ? 100 ASN A O   1 
ATOM   595  C CB  . ASN A 1 75  ? 139.377 166.586 176.362 1.00 56.02  ? 100 ASN A CB  1 
ATOM   596  C CG  . ASN A 1 75  ? 139.768 168.037 176.146 1.00 56.02  ? 100 ASN A CG  1 
ATOM   597  O OD1 . ASN A 1 75  ? 140.937 168.411 176.248 1.00 56.02  ? 100 ASN A OD1 1 
ATOM   598  N ND2 . ASN A 1 75  ? 138.774 168.863 175.836 1.00 56.02  ? 100 ASN A ND2 1 
ATOM   599  N N   . ALA A 1 76  ? 139.860 166.182 179.451 1.00 49.91  ? 101 ALA A N   1 
ATOM   600  C CA  . ALA A 1 76  ? 140.080 166.753 180.779 1.00 49.91  ? 101 ALA A CA  1 
ATOM   601  C C   . ALA A 1 76  ? 141.327 166.169 181.440 1.00 49.91  ? 101 ALA A C   1 
ATOM   602  O O   . ALA A 1 76  ? 142.128 166.901 182.042 1.00 49.91  ? 101 ALA A O   1 
ATOM   603  C CB  . ALA A 1 76  ? 138.851 166.525 181.657 1.00 49.91  ? 101 ALA A CB  1 
ATOM   604  N N   . THR A 1 77  ? 141.505 164.849 181.341 1.00 46.92  ? 102 THR A N   1 
ATOM   605  C CA  . THR A 1 77  ? 142.675 164.215 181.935 1.00 46.92  ? 102 THR A CA  1 
ATOM   606  C C   . THR A 1 77  ? 143.954 164.693 181.265 1.00 46.92  ? 102 THR A C   1 
ATOM   607  O O   . THR A 1 77  ? 144.968 164.913 181.935 1.00 46.92  ? 102 THR A O   1 
ATOM   608  C CB  . THR A 1 77  ? 142.555 162.695 181.839 1.00 46.92  ? 102 THR A CB  1 
ATOM   609  O OG1 . THR A 1 77  ? 141.313 162.277 182.418 1.00 46.92  ? 102 THR A OG1 1 
ATOM   610  C CG2 . THR A 1 77  ? 143.699 162.025 182.579 1.00 46.92  ? 102 THR A CG2 1 
ATOM   611  N N   . LEU A 1 78  ? 143.925 164.872 179.942 1.00 51.14  ? 103 LEU A N   1 
ATOM   612  C CA  . LEU A 1 78  ? 145.098 165.401 179.258 1.00 51.14  ? 103 LEU A CA  1 
ATOM   613  C C   . LEU A 1 78  ? 145.392 166.833 179.681 1.00 51.14  ? 103 LEU A C   1 
ATOM   614  O O   . LEU A 1 78  ? 146.561 167.216 179.784 1.00 51.14  ? 103 LEU A O   1 
ATOM   615  C CB  . LEU A 1 78  ? 144.913 165.317 177.744 1.00 51.14  ? 103 LEU A CB  1 
ATOM   616  C CG  . LEU A 1 78  ? 144.939 163.905 177.160 1.00 51.14  ? 103 LEU A CG  1 
ATOM   617  C CD1 . LEU A 1 78  ? 144.226 163.874 175.826 1.00 51.14  ? 103 LEU A CD1 1 
ATOM   618  C CD2 . LEU A 1 78  ? 146.365 163.398 177.022 1.00 51.14  ? 103 LEU A CD2 1 
ATOM   619  N N   . GLY A 1 79  ? 144.356 167.632 179.943 1.00 51.32  ? 104 GLY A N   1 
ATOM   620  C CA  . GLY A 1 79  ? 144.593 168.975 180.452 1.00 51.32  ? 104 GLY A CA  1 
ATOM   621  C C   . GLY A 1 79  ? 145.269 168.969 181.811 1.00 51.32  ? 104 GLY A C   1 
ATOM   622  O O   . GLY A 1 79  ? 146.232 169.709 182.051 1.00 51.32  ? 104 GLY A O   1 
ATOM   623  N N   . CYS A 1 80  ? 144.771 168.130 182.723 1.00 48.91  ? 105 CYS A N   1 
ATOM   624  C CA  . CYS A 1 80  ? 145.391 168.033 184.044 1.00 48.91  ? 105 CYS A CA  1 
ATOM   625  C C   . CYS A 1 80  ? 146.828 167.528 183.944 1.00 48.91  ? 105 CYS A C   1 
ATOM   626  O O   . CYS A 1 80  ? 147.721 168.008 184.661 1.00 48.91  ? 105 CYS A O   1 
ATOM   627  C CB  . CYS A 1 80  ? 144.564 167.120 184.948 1.00 48.91  ? 105 CYS A CB  1 
ATOM   628  S SG  . CYS A 1 80  ? 142.881 167.702 185.253 1.00 48.91  ? 105 CYS A SG  1 
ATOM   629  N N   . VAL A 1 81  ? 147.070 166.561 183.057 1.00 49.01  ? 106 VAL A N   1 
ATOM   630  C CA  . VAL A 1 81  ? 148.419 166.046 182.860 1.00 49.01  ? 106 VAL A CA  1 
ATOM   631  C C   . VAL A 1 81  ? 149.327 167.134 182.304 1.00 49.01  ? 106 VAL A C   1 
ATOM   632  O O   . VAL A 1 81  ? 150.493 167.241 182.694 1.00 49.01  ? 106 VAL A O   1 
ATOM   633  C CB  . VAL A 1 81  ? 148.387 164.807 181.947 1.00 49.01  ? 106 VAL A CB  1 
ATOM   634  C CG1 . VAL A 1 81  ? 149.780 164.479 181.434 1.00 49.01  ? 106 VAL A CG1 1 
ATOM   635  C CG2 . VAL A 1 81  ? 147.803 163.619 182.691 1.00 49.01  ? 106 VAL A CG2 1 
ATOM   636  N N   . LEU A 1 82  ? 148.809 167.965 181.396 1.00 53.28  ? 107 LEU A N   1 
ATOM   637  C CA  . LEU A 1 82  ? 149.600 169.070 180.864 1.00 53.28  ? 107 LEU A CA  1 
ATOM   638  C C   . LEU A 1 82  ? 149.964 170.061 181.960 1.00 53.28  ? 107 LEU A C   1 
ATOM   639  O O   . LEU A 1 82  ? 151.094 170.560 182.006 1.00 53.28  ? 107 LEU A O   1 
ATOM   640  C CB  . LEU A 1 82  ? 148.836 169.771 179.742 1.00 53.28  ? 107 LEU A CB  1 
ATOM   641  C CG  . LEU A 1 82  ? 149.167 169.341 178.314 1.00 53.28  ? 107 LEU A CG  1 
ATOM   642  C CD1 . LEU A 1 82  ? 148.270 170.062 177.324 1.00 53.28  ? 107 LEU A CD1 1 
ATOM   643  C CD2 . LEU A 1 82  ? 150.631 169.606 178.006 1.00 53.28  ? 107 LEU A CD2 1 
ATOM   644  N N   . HIS A 1 83  ? 149.018 170.355 182.853 1.00 55.50  ? 108 HIS A N   1 
ATOM   645  C CA  . HIS A 1 83  ? 149.308 171.251 183.971 1.00 55.50  ? 108 HIS A CA  1 
ATOM   646  C C   . HIS A 1 83  ? 150.420 170.690 184.854 1.00 55.50  ? 108 HIS A C   1 
ATOM   647  O O   . HIS A 1 83  ? 151.418 171.372 185.139 1.00 55.50  ? 108 HIS A O   1 
ATOM   648  C CB  . HIS A 1 83  ? 148.036 171.486 184.786 1.00 55.50  ? 108 HIS A CB  1 
ATOM   649  C CG  . HIS A 1 83  ? 148.215 172.430 185.934 1.00 55.50  ? 108 HIS A CG  1 
ATOM   650  N ND1 . HIS A 1 83  ? 147.332 172.489 186.990 1.00 55.50  ? 108 HIS A ND1 1 
ATOM   651  C CD2 . HIS A 1 83  ? 149.170 173.355 186.190 1.00 55.50  ? 108 HIS A CD2 1 
ATOM   652  C CE1 . HIS A 1 83  ? 147.737 173.407 187.849 1.00 55.50  ? 108 HIS A CE1 1 
ATOM   653  N NE2 . HIS A 1 83  ? 148.850 173.947 187.387 1.00 55.50  ? 108 HIS A NE2 1 
ATOM   654  N N   . ARG A 1 84  ? 150.266 169.439 185.296 1.00 54.67  ? 109 ARG A N   1 
ATOM   655  C CA  . ARG A 1 84  ? 151.271 168.858 186.183 1.00 54.67  ? 109 ARG A CA  1 
ATOM   656  C C   . ARG A 1 84  ? 152.611 168.675 185.476 1.00 54.67  ? 109 ARG A C   1 
ATOM   657  O O   . ARG A 1 84  ? 153.666 168.764 186.115 1.00 54.67  ? 109 ARG A O   1 
ATOM   658  C CB  . ARG A 1 84  ? 150.772 167.531 186.751 1.00 54.67  ? 109 ARG A CB  1 
ATOM   659  C CG  . ARG A 1 84  ? 149.811 167.700 187.919 1.00 54.67  ? 109 ARG A CG  1 
ATOM   660  C CD  . ARG A 1 84  ? 149.657 166.416 188.718 1.00 54.67  ? 109 ARG A CD  1 
ATOM   661  N NE  . ARG A 1 84  ? 148.695 165.503 188.108 1.00 54.67  ? 109 ARG A NE  1 
ATOM   662  C CZ  . ARG A 1 84  ? 148.273 164.377 188.672 1.00 54.67  ? 109 ARG A CZ  1 
ATOM   663  N NH1 . ARG A 1 84  ? 148.726 164.020 189.866 1.00 54.67  ? 109 ARG A NH1 1 
ATOM   664  N NH2 . ARG A 1 84  ? 147.397 163.606 188.043 1.00 54.67  ? 109 ARG A NH2 1 
ATOM   665  N N   . LEU A 1 85  ? 152.596 168.462 184.158 1.00 55.52  ? 110 LEU A N   1 
ATOM   666  C CA  . LEU A 1 85  ? 153.843 168.330 183.417 1.00 55.52  ? 110 LEU A CA  1 
ATOM   667  C C   . LEU A 1 85  ? 154.534 169.676 183.263 1.00 55.52  ? 110 LEU A C   1 
ATOM   668  O O   . LEU A 1 85  ? 155.766 169.743 183.297 1.00 55.52  ? 110 LEU A O   1 
ATOM   669  C CB  . LEU A 1 85  ? 153.569 167.694 182.053 1.00 55.52  ? 110 LEU A CB  1 
ATOM   670  C CG  . LEU A 1 85  ? 154.661 166.877 181.352 1.00 55.52  ? 110 LEU A CG  1 
ATOM   671  C CD1 . LEU A 1 85  ? 154.063 166.144 180.166 1.00 55.52  ? 110 LEU A CD1 1 
ATOM   672  C CD2 . LEU A 1 85  ? 155.839 167.724 180.894 1.00 55.52  ? 110 LEU A CD2 1 
ATOM   673  N N   . ALA A 1 86  ? 153.766 170.754 183.092 1.00 57.49  ? 111 ALA A N   1 
ATOM   674  C CA  . ALA A 1 86  ? 154.361 172.084 183.124 1.00 57.49  ? 111 ALA A CA  1 
ATOM   675  C C   . ALA A 1 86  ? 155.008 172.351 184.475 1.00 57.49  ? 111 ALA A C   1 
ATOM   676  O O   . ALA A 1 86  ? 156.113 172.903 184.546 1.00 57.49  ? 111 ALA A O   1 
ATOM   677  C CB  . ALA A 1 86  ? 153.306 173.145 182.814 1.00 57.49  ? 111 ALA A CB  1 
ATOM   678  N N   . ASP A 1 87  ? 154.340 171.948 185.558 1.00 60.77  ? 112 ASP A N   1 
ATOM   679  C CA  . ASP A 1 87  ? 154.938 172.097 186.884 1.00 60.77  ? 112 ASP A CA  1 
ATOM   680  C C   . ASP A 1 87  ? 156.256 171.331 186.981 1.00 60.77  ? 112 ASP A C   1 
ATOM   681  O O   . ASP A 1 87  ? 157.279 171.871 187.425 1.00 60.77  ? 112 ASP A O   1 
ATOM   682  C CB  . ASP A 1 87  ? 153.962 171.624 187.960 1.00 60.77  ? 112 ASP A CB  1 
ATOM   683  C CG  . ASP A 1 87  ? 154.445 171.941 189.362 1.00 60.77  ? 112 ASP A CG  1 
ATOM   684  O OD1 . ASP A 1 87  ? 155.385 172.752 189.500 1.00 60.77  ? 112 ASP A OD1 1 
ATOM   685  O OD2 . ASP A 1 87  ? 153.886 171.380 190.326 1.00 60.77  ? 112 ASP A OD2 1 
ATOM   686  N N   . LEU A 1 88  ? 156.248 170.062 186.565 1.00 59.63  ? 113 LEU A N   1 
ATOM   687  C CA  . LEU A 1 88  ? 157.470 169.266 186.606 1.00 59.63  ? 113 LEU A CA  1 
ATOM   688  C C   . LEU A 1 88  ? 158.579 169.918 185.792 1.00 59.63  ? 113 LEU A C   1 
ATOM   689  O O   . LEU A 1 88  ? 159.683 170.136 186.302 1.00 59.63  ? 113 LEU A O   1 
ATOM   690  C CB  . LEU A 1 88  ? 157.194 167.849 186.103 1.00 59.63  ? 113 LEU A CB  1 
ATOM   691  C CG  . LEU A 1 88  ? 156.437 166.936 187.067 1.00 59.63  ? 113 LEU A CG  1 
ATOM   692  C CD1 . LEU A 1 88  ? 156.329 165.531 186.502 1.00 59.63  ? 113 LEU A CD1 1 
ATOM   693  C CD2 . LEU A 1 88  ? 157.113 166.917 188.426 1.00 59.63  ? 113 LEU A CD2 1 
ATOM   694  N N   . GLU A 1 89  ? 158.296 170.265 184.533 1.00 66.82  ? 114 GLU A N   1 
ATOM   695  C CA  . GLU A 1 89  ? 159.307 170.890 183.687 1.00 66.82  ? 114 GLU A CA  1 
ATOM   696  C C   . GLU A 1 89  ? 159.837 172.176 184.304 1.00 66.82  ? 114 GLU A C   1 
ATOM   697  O O   . GLU A 1 89  ? 161.015 172.507 184.129 1.00 66.82  ? 114 GLU A O   1 
ATOM   698  C CB  . GLU A 1 89  ? 158.737 171.166 182.296 1.00 66.82  ? 114 GLU A CB  1 
ATOM   699  C CG  . GLU A 1 89  ? 159.801 171.328 181.223 1.00 66.82  ? 114 GLU A CG  1 
ATOM   700  C CD  . GLU A 1 89  ? 159.262 171.951 179.951 1.00 66.82  ? 114 GLU A CD  1 
ATOM   701  O OE1 . GLU A 1 89  ? 158.983 171.198 178.994 1.00 66.82  ? 114 GLU A OE1 1 
ATOM   702  O OE2 . GLU A 1 89  ? 159.120 173.190 179.905 1.00 66.82  ? 114 GLU A OE2 1 
ATOM   703  N N   . GLN A 1 90  ? 158.991 172.911 185.028 1.00 67.58  ? 115 GLN A N   1 
ATOM   704  C CA  . GLN A 1 90  ? 159.492 174.034 185.810 1.00 67.58  ? 115 GLN A CA  1 
ATOM   705  C C   . GLN A 1 90  ? 160.461 173.555 186.884 1.00 67.58  ? 115 GLN A C   1 
ATOM   706  O O   . GLN A 1 90  ? 161.437 174.244 187.204 1.00 67.58  ? 115 GLN A O   1 
ATOM   707  C CB  . GLN A 1 90  ? 158.328 174.800 186.437 1.00 67.58  ? 115 GLN A CB  1 
ATOM   708  C CG  . GLN A 1 90  ? 158.749 175.866 187.435 1.00 67.58  ? 115 GLN A CG  1 
ATOM   709  C CD  . GLN A 1 90  ? 157.569 176.495 188.149 1.00 67.58  ? 115 GLN A CD  1 
ATOM   710  O OE1 . GLN A 1 90  ? 156.414 176.253 187.798 1.00 67.58  ? 115 GLN A OE1 1 
ATOM   711  N NE2 . GLN A 1 90  ? 157.854 177.304 189.163 1.00 67.58  ? 115 GLN A NE2 1 
ATOM   712  N N   . ARG A 1 91  ? 160.216 172.367 187.441 1.00 67.97  ? 116 ARG A N   1 
ATOM   713  C CA  . ARG A 1 91  ? 161.080 171.868 188.509 1.00 67.97  ? 116 ARG A CA  1 
ATOM   714  C C   . ARG A 1 91  ? 162.349 171.187 187.993 1.00 67.97  ? 116 ARG A C   1 
ATOM   715  O O   . ARG A 1 91  ? 163.335 171.098 188.734 1.00 67.97  ? 116 ARG A O   1 
ATOM   716  C CB  . ARG A 1 91  ? 160.298 170.903 189.402 1.00 67.97  ? 116 ARG A CB  1 
ATOM   717  C CG  . ARG A 1 91  ? 160.896 170.721 190.790 1.00 67.97  ? 116 ARG A CG  1 
ATOM   718  C CD  . ARG A 1 91  ? 161.092 172.057 191.481 1.00 67.97  ? 116 ARG A CD  1 
ATOM   719  N NE  . ARG A 1 91  ? 159.878 172.867 191.459 1.00 67.97  ? 116 ARG A NE  1 
ATOM   720  C CZ  . ARG A 1 91  ? 158.880 172.739 192.326 1.00 67.97  ? 116 ARG A CZ  1 
ATOM   721  N NH1 . ARG A 1 91  ? 158.949 171.829 193.288 1.00 67.97  ? 116 ARG A NH1 1 
ATOM   722  N NH2 . ARG A 1 91  ? 157.813 173.521 192.235 1.00 67.97  ? 116 ARG A NH2 1 
ATOM   723  N N   . LEU A 1 92  ? 162.356 170.702 186.751 1.00 71.98  ? 117 LEU A N   1 
ATOM   724  C CA  . LEU A 1 92  ? 163.504 169.955 186.248 1.00 71.98  ? 117 LEU A CA  1 
ATOM   725  C C   . LEU A 1 92  ? 164.733 170.850 186.080 1.00 71.98  ? 117 LEU A C   1 
ATOM   726  O O   . LEU A 1 92  ? 164.611 172.066 185.912 1.00 71.98  ? 117 LEU A O   1 
ATOM   727  C CB  . LEU A 1 92  ? 163.173 169.282 184.916 1.00 71.98  ? 117 LEU A CB  1 
ATOM   728  C CG  . LEU A 1 92  ? 162.658 167.838 184.924 1.00 71.98  ? 117 LEU A CG  1 
ATOM   729  C CD1 . LEU A 1 92  ? 161.265 167.708 185.483 1.00 71.98  ? 117 LEU A CD1 1 
ATOM   730  C CD2 . LEU A 1 92  ? 162.724 167.254 183.521 1.00 71.98  ? 117 LEU A CD2 1 
ATOM   731  N N   . PRO A 1 93  ? 165.941 170.261 186.129 1.00 77.40  ? 118 PRO A N   1 
ATOM   732  C CA  . PRO A 1 93  ? 167.171 171.045 185.941 1.00 77.40  ? 118 PRO A CA  1 
ATOM   733  C C   . PRO A 1 93  ? 167.408 171.452 184.495 1.00 77.40  ? 118 PRO A C   1 
ATOM   734  O O   . PRO A 1 93  ? 166.543 171.259 183.635 1.00 77.40  ? 118 PRO A O   1 
ATOM   735  C CB  . PRO A 1 93  ? 168.275 170.096 186.435 1.00 77.40  ? 118 PRO A CB  1 
ATOM   736  C CG  . PRO A 1 93  ? 167.576 169.008 187.179 1.00 77.40  ? 118 PRO A CG  1 
ATOM   737  C CD  . PRO A 1 93  ? 166.235 168.878 186.534 1.00 77.40  ? 118 PRO A CD  1 
ATOM   738  N N   . LYS A 1 94  ? 168.580 172.017 184.220 1.00 91.18  ? 119 LYS A N   1 
ATOM   739  C CA  . LYS A 1 94  ? 168.913 172.548 182.906 1.00 91.18  ? 119 LYS A CA  1 
ATOM   740  C C   . LYS A 1 94  ? 169.962 171.686 182.204 1.00 91.18  ? 119 LYS A C   1 
ATOM   741  O O   . LYS A 1 94  ? 170.539 170.758 182.777 1.00 91.18  ? 119 LYS A O   1 
ATOM   742  C CB  . LYS A 1 94  ? 169.404 173.993 183.024 1.00 91.18  ? 119 LYS A CB  1 
ATOM   743  C CG  . LYS A 1 94  ? 168.362 175.032 182.642 1.00 91.18  ? 119 LYS A CG  1 
ATOM   744  C CD  . LYS A 1 94  ? 167.073 174.832 183.425 1.00 91.18  ? 119 LYS A CD  1 
ATOM   745  C CE  . LYS A 1 94  ? 166.061 175.920 183.117 1.00 91.18  ? 119 LYS A CE  1 
ATOM   746  N NZ  . LYS A 1 94  ? 164.754 175.662 183.779 1.00 91.18  ? 119 LYS A NZ  1 
ATOM   747  N N   . ALA A 1 95  ? 170.214 172.028 180.937 1.00 99.38  ? 120 ALA A N   1 
ATOM   748  C CA  . ALA A 1 95  ? 171.097 171.221 180.100 1.00 99.38  ? 120 ALA A CA  1 
ATOM   749  C C   . ALA A 1 95  ? 172.548 171.320 180.557 1.00 99.38  ? 120 ALA A C   1 
ATOM   750  O O   . ALA A 1 95  ? 173.249 170.306 180.650 1.00 99.38  ? 120 ALA A O   1 
ATOM   751  C CB  . ALA A 1 95  ? 170.964 171.646 178.638 1.00 99.38  ? 120 ALA A CB  1 
ATOM   752  N N   . GLN A 1 96  ? 173.025 172.538 180.827 1.00 103.77 ? 121 GLN A N   1 
ATOM   753  C CA  . GLN A 1 96  ? 174.389 172.691 181.323 1.00 103.77 ? 121 GLN A CA  1 
ATOM   754  C C   . GLN A 1 96  ? 174.562 172.027 182.682 1.00 103.77 ? 121 GLN A C   1 
ATOM   755  O O   . GLN A 1 96  ? 175.627 171.468 182.970 1.00 103.77 ? 121 GLN A O   1 
ATOM   756  C CB  . GLN A 1 96  ? 174.764 174.173 181.397 1.00 103.77 ? 121 GLN A CB  1 
ATOM   757  C CG  . GLN A 1 96  ? 173.799 175.033 182.198 1.00 103.77 ? 121 GLN A CG  1 
ATOM   758  C CD  . GLN A 1 96  ? 172.695 175.622 181.343 1.00 103.77 ? 121 GLN A CD  1 
ATOM   759  O OE1 . GLN A 1 96  ? 172.246 175.006 180.376 1.00 103.77 ? 121 GLN A OE1 1 
ATOM   760  N NE2 . GLN A 1 96  ? 172.251 176.822 181.695 1.00 103.77 ? 121 GLN A NE2 1 
ATOM   761  N N   . ASP A 1 97  ? 173.525 172.064 183.521 1.00 100.53 ? 122 ASP A N   1 
ATOM   762  C CA  . ASP A 1 97  ? 173.579 171.368 184.801 1.00 100.53 ? 122 ASP A CA  1 
ATOM   763  C C   . ASP A 1 97  ? 173.712 169.864 184.597 1.00 100.53 ? 122 ASP A C   1 
ATOM   764  O O   . ASP A 1 97  ? 174.529 169.206 185.253 1.00 100.53 ? 122 ASP A O   1 
ATOM   765  C CB  . ASP A 1 97  ? 172.334 171.697 185.625 1.00 100.53 ? 122 ASP A CB  1 
ATOM   766  C CG  . ASP A 1 97  ? 172.362 171.064 187.001 1.00 100.53 ? 122 ASP A CG  1 
ATOM   767  O OD1 . ASP A 1 97  ? 172.578 171.798 187.986 1.00 100.53 ? 122 ASP A OD1 1 
ATOM   768  O OD2 . ASP A 1 97  ? 172.157 169.836 187.097 1.00 100.53 ? 122 ASP A OD2 1 
ATOM   769  N N   . LEU A 1 98  ? 172.904 169.299 183.695 1.00 98.61  ? 123 LEU A N   1 
ATOM   770  C CA  . LEU A 1 98  ? 173.015 167.875 183.398 1.00 98.61  ? 123 LEU A CA  1 
ATOM   771  C C   . LEU A 1 98  ? 174.387 167.525 182.839 1.00 98.61  ? 123 LEU A C   1 
ATOM   772  O O   . LEU A 1 98  ? 174.930 166.458 183.147 1.00 98.61  ? 123 LEU A O   1 
ATOM   773  C CB  . LEU A 1 98  ? 171.924 167.454 182.416 1.00 98.61  ? 123 LEU A CB  1 
ATOM   774  C CG  . LEU A 1 98  ? 170.694 166.767 183.009 1.00 98.61  ? 123 LEU A CG  1 
ATOM   775  C CD1 . LEU A 1 98  ? 169.940 167.701 183.944 1.00 98.61  ? 123 LEU A CD1 1 
ATOM   776  C CD2 . LEU A 1 98  ? 169.790 166.266 181.898 1.00 98.61  ? 123 LEU A CD2 1 
ATOM   777  N N   . GLU A 1 99  ? 174.961 168.409 182.022 1.00 106.97 ? 124 GLU A N   1 
ATOM   778  C CA  . GLU A 1 99  ? 176.282 168.151 181.457 1.00 106.97 ? 124 GLU A CA  1 
ATOM   779  C C   . GLU A 1 99  ? 177.351 168.152 182.543 1.00 106.97 ? 124 GLU A C   1 
ATOM   780  O O   . GLU A 1 99  ? 178.225 167.277 182.570 1.00 106.97 ? 124 GLU A O   1 
ATOM   781  C CB  . GLU A 1 99  ? 176.602 169.188 180.380 1.00 106.97 ? 124 GLU A CB  1 
ATOM   782  C CG  . GLU A 1 99  ? 178.028 169.123 179.856 1.00 106.97 ? 124 GLU A CG  1 
ATOM   783  C CD  . GLU A 1 99  ? 178.405 167.740 179.362 1.00 106.97 ? 124 GLU A CD  1 
ATOM   784  O OE1 . GLU A 1 99  ? 179.301 167.115 179.966 1.00 106.97 ? 124 GLU A OE1 1 
ATOM   785  O OE2 . GLU A 1 99  ? 177.803 167.278 178.370 1.00 106.97 ? 124 GLU A OE2 1 
ATOM   786  N N   . ARG A 1 100 ? 177.298 169.130 183.451 1.00 108.67 ? 125 ARG A N   1 
ATOM   787  C CA  . ARG A 1 100 ? 178.274 169.178 184.535 1.00 108.67 ? 125 ARG A CA  1 
ATOM   788  C C   . ARG A 1 100 ? 178.099 168.017 185.505 1.00 108.67 ? 125 ARG A C   1 
ATOM   789  O O   . ARG A 1 100 ? 179.077 167.557 186.104 1.00 108.67 ? 125 ARG A O   1 
ATOM   790  C CB  . ARG A 1 100 ? 178.175 170.510 185.280 1.00 108.67 ? 125 ARG A CB  1 
ATOM   791  C CG  . ARG A 1 100 ? 178.429 171.730 184.412 1.00 108.67 ? 125 ARG A CG  1 
ATOM   792  C CD  . ARG A 1 100 ? 179.740 171.610 183.653 1.00 108.67 ? 125 ARG A CD  1 
ATOM   793  N NE  . ARG A 1 100 ? 179.814 172.557 182.544 1.00 108.67 ? 125 ARG A NE  1 
ATOM   794  C CZ  . ARG A 1 100 ? 180.261 173.804 182.655 1.00 108.67 ? 125 ARG A CZ  1 
ATOM   795  N NH1 . ARG A 1 100 ? 180.292 174.595 181.592 1.00 108.67 ? 125 ARG A NH1 1 
ATOM   796  N NH2 . ARG A 1 100 ? 180.676 174.260 183.828 1.00 108.67 ? 125 ARG A NH2 1 
ATOM   797  N N   . SER A 1 101 ? 176.868 167.527 185.672 1.00 103.93 ? 126 SER A N   1 
ATOM   798  C CA  . SER A 1 101 ? 176.636 166.421 186.596 1.00 103.93 ? 126 SER A CA  1 
ATOM   799  C C   . SER A 1 101 ? 177.072 165.087 186.000 1.00 103.93 ? 126 SER A C   1 
ATOM   800  O O   . SER A 1 101 ? 177.738 164.294 186.674 1.00 103.93 ? 126 SER A O   1 
ATOM   801  C CB  . SER A 1 101 ? 175.161 166.370 186.994 1.00 103.93 ? 126 SER A CB  1 
ATOM   802  O OG  . SER A 1 101 ? 174.877 167.302 188.023 1.00 103.93 ? 126 SER A OG  1 
ATOM   803  N N   . GLY A 1 102 ? 176.709 164.822 184.748 1.00 101.23 ? 127 GLY A N   1 
ATOM   804  C CA  . GLY A 1 102 ? 177.058 163.569 184.110 1.00 101.23 ? 127 GLY A CA  1 
ATOM   805  C C   . GLY A 1 102 ? 175.849 162.779 183.653 1.00 101.23 ? 127 GLY A C   1 
ATOM   806  O O   . GLY A 1 102 ? 175.970 161.617 183.254 1.00 101.23 ? 127 GLY A O   1 
ATOM   807  N N   . LEU A 1 103 ? 174.675 163.402 183.707 1.00 94.03  ? 128 LEU A N   1 
ATOM   808  C CA  . LEU A 1 103 ? 173.435 162.750 183.310 1.00 94.03  ? 128 LEU A CA  1 
ATOM   809  C C   . LEU A 1 103 ? 173.292 162.802 181.789 1.00 94.03  ? 128 LEU A C   1 
ATOM   810  O O   . LEU A 1 103 ? 174.228 163.149 181.062 1.00 94.03  ? 128 LEU A O   1 
ATOM   811  C CB  . LEU A 1 103 ? 172.250 163.393 184.025 1.00 94.03  ? 128 LEU A CB  1 
ATOM   812  C CG  . LEU A 1 103 ? 172.362 163.481 185.548 1.00 94.03  ? 128 LEU A CG  1 
ATOM   813  C CD1 . LEU A 1 103 ? 171.108 164.095 186.148 1.00 94.03  ? 128 LEU A CD1 1 
ATOM   814  C CD2 . LEU A 1 103 ? 172.632 162.110 186.147 1.00 94.03  ? 128 LEU A CD2 1 
ATOM   815  N N   . ASN A 1 104 ? 172.109 162.455 181.288 1.00 92.32  ? 129 ASN A N   1 
ATOM   816  C CA  . ASN A 1 104 ? 171.838 162.400 179.858 1.00 92.32  ? 129 ASN A CA  1 
ATOM   817  C C   . ASN A 1 104 ? 170.822 163.469 179.488 1.00 92.32  ? 129 ASN A C   1 
ATOM   818  O O   . ASN A 1 104 ? 169.759 163.564 180.111 1.00 92.32  ? 129 ASN A O   1 
ATOM   819  C CB  . ASN A 1 104 ? 171.321 161.017 179.451 1.00 92.32  ? 129 ASN A CB  1 
ATOM   820  C CG  . ASN A 1 104 ? 172.431 159.996 179.316 1.00 92.32  ? 129 ASN A CG  1 
ATOM   821  O OD1 . ASN A 1 104 ? 173.545 160.324 178.907 1.00 92.32  ? 129 ASN A OD1 1 
ATOM   822  N ND2 . ASN A 1 104 ? 172.133 158.748 179.660 1.00 92.32  ? 129 ASN A ND2 1 
ATOM   823  N N   . ILE A 1 105 ? 171.149 164.267 178.467 1.00 86.05  ? 130 ILE A N   1 
ATOM   824  C CA  . ILE A 1 105 ? 170.231 165.295 177.989 1.00 86.05  ? 130 ILE A CA  1 
ATOM   825  C C   . ILE A 1 105 ? 169.031 164.674 177.284 1.00 86.05  ? 130 ILE A C   1 
ATOM   826  O O   . ILE A 1 105 ? 167.985 165.327 177.142 1.00 86.05  ? 130 ILE A O   1 
ATOM   827  C CB  . ILE A 1 105 ? 170.973 166.278 177.061 1.00 86.05  ? 130 ILE A CB  1 
ATOM   828  C CG1 . ILE A 1 105 ? 172.287 166.735 177.698 1.00 86.05  ? 130 ILE A CG1 1 
ATOM   829  C CG2 . ILE A 1 105 ? 170.113 167.496 176.757 1.00 86.05  ? 130 ILE A CG2 1 
ATOM   830  C CD1 . ILE A 1 105 ? 173.514 166.013 177.173 1.00 86.05  ? 130 ILE A CD1 1 
ATOM   831  N N   . GLU A 1 106 ? 169.157 163.414 176.855 1.00 83.49  ? 131 GLU A N   1 
ATOM   832  C CA  . GLU A 1 106 ? 168.063 162.732 176.175 1.00 83.49  ? 131 GLU A CA  1 
ATOM   833  C C   . GLU A 1 106 ? 166.790 162.729 177.009 1.00 83.49  ? 131 GLU A C   1 
ATOM   834  O O   . GLU A 1 106 ? 165.689 162.709 176.453 1.00 83.49  ? 131 GLU A O   1 
ATOM   835  C CB  . GLU A 1 106 ? 168.474 161.300 175.832 1.00 83.49  ? 131 GLU A CB  1 
ATOM   836  C CG  . GLU A 1 106 ? 167.954 160.812 174.492 1.00 83.49  ? 131 GLU A CG  1 
ATOM   837  C CD  . GLU A 1 106 ? 168.680 161.446 173.321 1.00 83.49  ? 131 GLU A CD  1 
ATOM   838  O OE1 . GLU A 1 106 ? 169.794 161.972 173.524 1.00 83.49  ? 131 GLU A OE1 1 
ATOM   839  O OE2 . GLU A 1 106 ? 168.134 161.420 172.198 1.00 83.49  ? 131 GLU A OE2 1 
ATOM   840  N N   . ASP A 1 107 ? 166.913 162.771 178.336 1.00 76.63  ? 132 ASP A N   1 
ATOM   841  C CA  . ASP A 1 107 ? 165.730 162.827 179.189 1.00 76.63  ? 132 ASP A CA  1 
ATOM   842  C C   . ASP A 1 107 ? 164.973 164.136 178.992 1.00 76.63  ? 132 ASP A C   1 
ATOM   843  O O   . ASP A 1 107 ? 163.746 164.141 178.813 1.00 76.63  ? 132 ASP A O   1 
ATOM   844  C CB  . ASP A 1 107 ? 166.142 162.650 180.649 1.00 76.63  ? 132 ASP A CB  1 
ATOM   845  C CG  . ASP A 1 107 ? 167.054 161.456 180.854 1.00 76.63  ? 132 ASP A CG  1 
ATOM   846  O OD1 . ASP A 1 107 ? 167.013 160.527 180.021 1.00 76.63  ? 132 ASP A OD1 1 
ATOM   847  O OD2 . ASP A 1 107 ? 167.815 161.448 181.844 1.00 76.63  ? 132 ASP A OD2 1 
ATOM   848  N N   . LEU A 1 108 ? 165.692 165.260 179.031 1.00 76.82  ? 133 LEU A N   1 
ATOM   849  C CA  . LEU A 1 108 ? 165.065 166.551 178.766 1.00 76.82  ? 133 LEU A CA  1 
ATOM   850  C C   . LEU A 1 108 ? 164.477 166.592 177.363 1.00 76.82  ? 133 LEU A C   1 
ATOM   851  O O   . LEU A 1 108 ? 163.380 167.128 177.155 1.00 76.82  ? 133 LEU A O   1 
ATOM   852  C CB  . LEU A 1 108 ? 166.083 167.676 178.951 1.00 76.82  ? 133 LEU A CB  1 
ATOM   853  C CG  . LEU A 1 108 ? 166.742 167.799 180.324 1.00 76.82  ? 133 LEU A CG  1 
ATOM   854  C CD1 . LEU A 1 108 ? 167.772 168.915 180.314 1.00 76.82  ? 133 LEU A CD1 1 
ATOM   855  C CD2 . LEU A 1 108 ? 165.698 168.038 181.401 1.00 76.82  ? 133 LEU A CD2 1 
ATOM   856  N N   . GLU A 1 109 ? 165.198 166.036 176.385 1.00 77.88  ? 134 GLU A N   1 
ATOM   857  C CA  . GLU A 1 109 ? 164.672 165.998 175.023 1.00 77.88  ? 134 GLU A CA  1 
ATOM   858  C C   . GLU A 1 109 ? 163.372 165.205 174.958 1.00 77.88  ? 134 GLU A C   1 
ATOM   859  O O   . GLU A 1 109 ? 162.409 165.628 174.307 1.00 77.88  ? 134 GLU A O   1 
ATOM   860  C CB  . GLU A 1 109 ? 165.706 165.410 174.060 1.00 77.88  ? 134 GLU A CB  1 
ATOM   861  C CG  . GLU A 1 109 ? 167.136 165.878 174.283 1.00 77.88  ? 134 GLU A CG  1 
ATOM   862  C CD  . GLU A 1 109 ? 167.412 167.272 173.743 1.00 77.88  ? 134 GLU A CD  1 
ATOM   863  O OE1 . GLU A 1 109 ? 166.452 168.035 173.505 1.00 77.88  ? 134 GLU A OE1 1 
ATOM   864  O OE2 . GLU A 1 109 ? 168.601 167.607 173.559 1.00 77.88  ? 134 GLU A OE2 1 
ATOM   865  N N   . LYS A 1 110 ? 163.317 164.066 175.649 1.00 69.78  ? 135 LYS A N   1 
ATOM   866  C CA  . LYS A 1 110 ? 162.122 163.232 175.615 1.00 69.78  ? 135 LYS A CA  1 
ATOM   867  C C   . LYS A 1 110 ? 160.947 163.918 176.297 1.00 69.78  ? 135 LYS A C   1 
ATOM   868  O O   . LYS A 1 110 ? 159.809 163.806 175.834 1.00 69.78  ? 135 LYS A O   1 
ATOM   869  C CB  . LYS A 1 110 ? 162.410 161.878 176.262 1.00 69.78  ? 135 LYS A CB  1 
ATOM   870  C CG  . LYS A 1 110 ? 163.242 160.950 175.392 1.00 69.78  ? 135 LYS A CG  1 
ATOM   871  C CD  . LYS A 1 110 ? 163.356 159.566 176.005 1.00 69.78  ? 135 LYS A CD  1 
ATOM   872  C CE  . LYS A 1 110 ? 164.078 158.607 175.075 1.00 69.78  ? 135 LYS A CE  1 
ATOM   873  N NZ  . LYS A 1 110 ? 164.130 157.229 175.637 1.00 69.78  ? 135 LYS A NZ  1 
ATOM   874  N N   . LEU A 1 111 ? 161.198 164.649 177.384 1.00 66.39  ? 136 LEU A N   1 
ATOM   875  C CA  . LEU A 1 111 ? 160.109 165.372 178.042 1.00 66.39  ? 136 LEU A CA  1 
ATOM   876  C C   . LEU A 1 111 ? 159.584 166.505 177.160 1.00 66.39  ? 136 LEU A C   1 
ATOM   877  O O   . LEU A 1 111 ? 158.362 166.666 176.979 1.00 66.39  ? 136 LEU A O   1 
ATOM   878  C CB  . LEU A 1 111 ? 160.583 165.913 179.391 1.00 66.39  ? 136 LEU A CB  1 
ATOM   879  C CG  . LEU A 1 111 ? 160.337 165.055 180.635 1.00 66.39  ? 136 LEU A CG  1 
ATOM   880  C CD1 . LEU A 1 111 ? 158.847 164.873 180.875 1.00 66.39  ? 136 LEU A CD1 1 
ATOM   881  C CD2 . LEU A 1 111 ? 161.036 163.707 180.535 1.00 66.39  ? 136 LEU A CD2 1 
ATOM   882  N N   . GLN A 1 112 ? 160.501 167.309 176.612 1.00 69.84  ? 137 GLN A N   1 
ATOM   883  C CA  . GLN A 1 112 ? 160.117 168.425 175.758 1.00 69.84  ? 137 GLN A CA  1 
ATOM   884  C C   . GLN A 1 112 ? 159.536 167.961 174.430 1.00 69.84  ? 137 GLN A C   1 
ATOM   885  O O   . GLN A 1 112 ? 158.948 168.774 173.710 1.00 69.84  ? 137 GLN A O   1 
ATOM   886  C CB  . GLN A 1 112 ? 161.322 169.333 175.515 1.00 69.84  ? 137 GLN A CB  1 
ATOM   887  C CG  . GLN A 1 112 ? 161.899 169.943 176.782 1.00 69.84  ? 137 GLN A CG  1 
ATOM   888  C CD  . GLN A 1 112 ? 163.370 170.284 176.647 1.00 69.84  ? 137 GLN A CD  1 
ATOM   889  O OE1 . GLN A 1 112 ? 164.030 169.868 175.696 1.00 69.84  ? 137 GLN A OE1 1 
ATOM   890  N NE2 . GLN A 1 112 ? 163.891 171.045 177.602 1.00 69.84  ? 137 GLN A NE2 1 
ATOM   891  N N   . MET A 1 113 ? 159.713 166.689 174.078 1.00 67.21  ? 138 MET A N   1 
ATOM   892  C CA  . MET A 1 113 ? 159.015 166.114 172.937 1.00 67.21  ? 138 MET A CA  1 
ATOM   893  C C   . MET A 1 113 ? 157.691 165.474 173.327 1.00 67.21  ? 138 MET A C   1 
ATOM   894  O O   . MET A 1 113 ? 156.782 165.391 172.494 1.00 67.21  ? 138 MET A O   1 
ATOM   895  C CB  . MET A 1 113 ? 159.902 165.073 172.248 1.00 67.21  ? 138 MET A CB  1 
ATOM   896  C CG  . MET A 1 113 ? 160.560 165.564 170.972 1.00 67.21  ? 138 MET A CG  1 
ATOM   897  S SD  . MET A 1 113 ? 159.365 166.118 169.741 1.00 67.21  ? 138 MET A SD  1 
ATOM   898  C CE  . MET A 1 113 ? 158.283 164.693 169.646 1.00 67.21  ? 138 MET A CE  1 
ATOM   899  N N   . ALA A 1 114 ? 157.565 165.021 174.576 1.00 63.18  ? 139 ALA A N   1 
ATOM   900  C CA  . ALA A 1 114 ? 156.332 164.380 175.014 1.00 63.18  ? 139 ALA A CA  1 
ATOM   901  C C   . ALA A 1 114 ? 155.230 165.394 175.272 1.00 63.18  ? 139 ALA A C   1 
ATOM   902  O O   . ALA A 1 114 ? 154.047 165.064 175.134 1.00 63.18  ? 139 ALA A O   1 
ATOM   903  C CB  . ALA A 1 114 ? 156.590 163.549 176.270 1.00 63.18  ? 139 ALA A CB  1 
ATOM   904  N N   . ARG A 1 115 ? 155.585 166.618 175.661 1.00 56.89  ? 140 ARG A N   1 
ATOM   905  C CA  . ARG A 1 115 ? 154.545 167.637 175.827 1.00 56.89  ? 140 ARG A CA  1 
ATOM   906  C C   . ARG A 1 115 ? 153.807 167.952 174.522 1.00 56.89  ? 140 ARG A C   1 
ATOM   907  O O   . ARG A 1 115 ? 152.560 167.888 174.506 1.00 56.89  ? 140 ARG A O   1 
ATOM   908  C CB  . ARG A 1 115 ? 155.147 168.897 176.459 1.00 56.89  ? 140 ARG A CB  1 
ATOM   909  C CG  . ARG A 1 115 ? 154.175 170.059 176.555 1.00 56.89  ? 140 ARG A CG  1 
ATOM   910  C CD  . ARG A 1 115 ? 154.816 171.261 177.226 1.00 56.89  ? 140 ARG A CD  1 
ATOM   911  N NE  . ARG A 1 115 ? 153.923 172.415 177.246 1.00 56.89  ? 140 ARG A NE  1 
ATOM   912  C CZ  . ARG A 1 115 ? 153.867 173.331 176.285 1.00 56.89  ? 140 ARG A CZ  1 
ATOM   913  N NH1 . ARG A 1 115 ? 154.654 173.230 175.223 1.00 56.89  ? 140 ARG A NH1 1 
ATOM   914  N NH2 . ARG A 1 115 ? 153.023 174.349 176.385 1.00 56.89  ? 140 ARG A NH2 1 
ATOM   915  N N   . PRO A 1 116 ? 154.478 168.284 173.411 1.00 53.38  ? 141 PRO A N   1 
ATOM   916  C CA  . PRO A 1 116 ? 153.736 168.501 172.160 1.00 53.38  ? 141 PRO A CA  1 
ATOM   917  C C   . PRO A 1 116 ? 153.018 167.261 171.667 1.00 53.38  ? 141 PRO A C   1 
ATOM   918  O O   . PRO A 1 116 ? 152.048 167.388 170.914 1.00 53.38  ? 141 PRO A O   1 
ATOM   919  C CB  . PRO A 1 116 ? 154.824 168.946 171.172 1.00 53.38  ? 141 PRO A CB  1 
ATOM   920  C CG  . PRO A 1 116 ? 155.953 169.400 172.022 1.00 53.38  ? 141 PRO A CG  1 
ATOM   921  C CD  . PRO A 1 116 ? 155.919 168.506 173.212 1.00 53.38  ? 141 PRO A CD  1 
ATOM   922  N N   . ASN A 1 117 ? 153.458 166.066 172.065 1.00 50.45  ? 142 ASN A N   1 
ATOM   923  C CA  . ASN A 1 117 ? 152.697 164.864 171.743 1.00 50.45  ? 142 ASN A CA  1 
ATOM   924  C C   . ASN A 1 117 ? 151.326 164.898 172.402 1.00 50.45  ? 142 ASN A C   1 
ATOM   925  O O   . ASN A 1 117 ? 150.318 164.543 171.780 1.00 50.45  ? 142 ASN A O   1 
ATOM   926  C CB  . ASN A 1 117 ? 153.473 163.620 172.174 1.00 50.45  ? 142 ASN A CB  1 
ATOM   927  C CG  . ASN A 1 117 ? 154.722 163.398 171.347 1.00 50.45  ? 142 ASN A CG  1 
ATOM   928  O OD1 . ASN A 1 117 ? 155.088 164.232 170.520 1.00 50.45  ? 142 ASN A OD1 1 
ATOM   929  N ND2 . ASN A 1 117 ? 155.385 162.270 171.568 1.00 50.45  ? 142 ASN A ND2 1 
ATOM   930  N N   . ILE A 1 118 ? 151.268 165.335 173.662 1.00 47.14  ? 143 ILE A N   1 
ATOM   931  C CA  . ILE A 1 118 ? 149.984 165.495 174.337 1.00 47.14  ? 143 ILE A CA  1 
ATOM   932  C C   . ILE A 1 118 ? 149.148 166.559 173.640 1.00 47.14  ? 143 ILE A C   1 
ATOM   933  O O   . ILE A 1 118 ? 147.932 166.398 173.458 1.00 47.14  ? 143 ILE A O   1 
ATOM   934  C CB  . ILE A 1 118 ? 150.203 165.832 175.823 1.00 47.14  ? 143 ILE A CB  1 
ATOM   935  C CG1 . ILE A 1 118 ? 151.100 164.782 176.480 1.00 47.14  ? 143 ILE A CG1 1 
ATOM   936  C CG2 . ILE A 1 118 ? 148.873 165.940 176.547 1.00 47.14  ? 143 ILE A CG2 1 
ATOM   937  C CD1 . ILE A 1 118 ? 151.265 164.966 177.971 1.00 47.14  ? 143 ILE A CD1 1 
ATOM   938  N N   . LEU A 1 119 ? 149.785 167.663 173.238 1.00 46.88  ? 144 LEU A N   1 
ATOM   939  C CA  . LEU A 1 119 ? 149.052 168.700 172.511 1.00 46.88  ? 144 LEU A CA  1 
ATOM   940  C C   . LEU A 1 119 ? 148.434 168.146 171.228 1.00 46.88  ? 144 LEU A C   1 
ATOM   941  O O   . LEU A 1 119 ? 147.253 168.382 170.934 1.00 46.88  ? 144 LEU A O   1 
ATOM   942  C CB  . LEU A 1 119 ? 149.978 169.876 172.201 1.00 46.88  ? 144 LEU A CB  1 
ATOM   943  C CG  . LEU A 1 119 ? 150.269 170.832 173.358 1.00 46.88  ? 144 LEU A CG  1 
ATOM   944  C CD1 . LEU A 1 119 ? 151.197 171.949 172.910 1.00 46.88  ? 144 LEU A CD1 1 
ATOM   945  C CD2 . LEU A 1 119 ? 148.977 171.399 173.919 1.00 46.88  ? 144 LEU A CD2 1 
ATOM   946  N N   . GLY A 1 120 ? 149.220 167.396 170.455 1.00 44.00  ? 145 GLY A N   1 
ATOM   947  C CA  . GLY A 1 120 ? 148.718 166.826 169.218 1.00 44.00  ? 145 GLY A CA  1 
ATOM   948  C C   . GLY A 1 120 ? 147.637 165.788 169.432 1.00 44.00  ? 145 GLY A C   1 
ATOM   949  O O   . GLY A 1 120 ? 146.704 165.687 168.631 1.00 44.00  ? 145 GLY A O   1 
ATOM   950  N N   . LEU A 1 121 ? 147.743 165.000 170.504 1.00 42.95  ? 146 LEU A N   1 
ATOM   951  C CA  . LEU A 1 121 ? 146.681 164.050 170.816 1.00 42.95  ? 146 LEU A CA  1 
ATOM   952  C C   . LEU A 1 121 ? 145.383 164.775 171.142 1.00 42.95  ? 146 LEU A C   1 
ATOM   953  O O   . LEU A 1 121 ? 144.300 164.344 170.727 1.00 42.95  ? 146 LEU A O   1 
ATOM   954  C CB  . LEU A 1 121 ? 147.103 163.148 171.975 1.00 42.95  ? 146 LEU A CB  1 
ATOM   955  C CG  . LEU A 1 121 ? 146.033 162.199 172.518 1.00 42.95  ? 146 LEU A CG  1 
ATOM   956  C CD1 . LEU A 1 121 ? 145.490 161.306 171.414 1.00 42.95  ? 146 LEU A CD1 1 
ATOM   957  C CD2 . LEU A 1 121 ? 146.590 161.363 173.657 1.00 42.95  ? 146 LEU A CD2 1 
ATOM   958  N N   . ARG A 1 122 ? 145.471 165.883 171.883 1.00 47.26  ? 147 ARG A N   1 
ATOM   959  C CA  . ARG A 1 122 ? 144.278 166.684 172.147 1.00 47.26  ? 147 ARG A CA  1 
ATOM   960  C C   . ARG A 1 122 ? 143.687 167.227 170.851 1.00 47.26  ? 147 ARG A C   1 
ATOM   961  O O   . ARG A 1 122 ? 142.462 167.217 170.658 1.00 47.26  ? 147 ARG A O   1 
ATOM   962  C CB  . ARG A 1 122 ? 144.621 167.825 173.102 1.00 47.26  ? 147 ARG A CB  1 
ATOM   963  C CG  . ARG A 1 122 ? 143.546 168.134 174.127 1.00 47.26  ? 147 ARG A CG  1 
ATOM   964  C CD  . ARG A 1 122 ? 143.983 169.275 175.029 1.00 47.26  ? 147 ARG A CD  1 
ATOM   965  N NE  . ARG A 1 122 ? 143.070 169.479 176.147 1.00 47.26  ? 147 ARG A NE  1 
ATOM   966  C CZ  . ARG A 1 122 ? 143.180 170.471 177.023 1.00 47.26  ? 147 ARG A CZ  1 
ATOM   967  N NH1 . ARG A 1 122 ? 142.305 170.586 178.013 1.00 47.26  ? 147 ARG A NH1 1 
ATOM   968  N NH2 . ARG A 1 122 ? 144.164 171.351 176.908 1.00 47.26  ? 147 ARG A NH2 1 
ATOM   969  N N   . ASN A 1 123 ? 144.549 167.700 169.948 1.00 44.83  ? 148 ASN A N   1 
ATOM   970  C CA  . ASN A 1 123 ? 144.092 168.164 168.640 1.00 44.83  ? 148 ASN A CA  1 
ATOM   971  C C   . ASN A 1 123 ? 143.346 167.065 167.892 1.00 44.83  ? 148 ASN A C   1 
ATOM   972  O O   . ASN A 1 123 ? 142.275 167.299 167.318 1.00 44.83  ? 148 ASN A O   1 
ATOM   973  C CB  . ASN A 1 123 ? 145.285 168.638 167.814 1.00 44.83  ? 148 ASN A CB  1 
ATOM   974  C CG  . ASN A 1 123 ? 144.878 169.238 166.487 1.00 44.83  ? 148 ASN A CG  1 
ATOM   975  O OD1 . ASN A 1 123 ? 143.694 169.394 166.192 1.00 44.83  ? 148 ASN A OD1 1 
ATOM   976  N ND2 . ASN A 1 123 ? 145.864 169.539 165.659 1.00 44.83  ? 148 ASN A ND2 1 
ATOM   977  N N   . ASN A 1 124 ? 143.913 165.860 167.873 1.00 46.66  ? 149 ASN A N   1 
ATOM   978  C CA  . ASN A 1 124 ? 143.295 164.768 167.133 1.00 46.66  ? 149 ASN A CA  1 
ATOM   979  C C   . ASN A 1 124 ? 141.975 164.348 167.760 1.00 46.66  ? 149 ASN A C   1 
ATOM   980  O O   . ASN A 1 124 ? 141.035 163.987 167.042 1.00 46.66  ? 149 ASN A O   1 
ATOM   981  C CB  . ASN A 1 124 ? 144.255 163.584 167.054 1.00 46.66  ? 149 ASN A CB  1 
ATOM   982  C CG  . ASN A 1 124 ? 143.911 162.636 165.934 1.00 46.66  ? 149 ASN A CG  1 
ATOM   983  O OD1 . ASN A 1 124 ? 143.056 162.930 165.099 1.00 46.66  ? 149 ASN A OD1 1 
ATOM   984  N ND2 . ASN A 1 124 ? 144.579 161.491 165.902 1.00 46.66  ? 149 ASN A ND2 1 
ATOM   985  N N   . ILE A 1 125 ? 141.883 164.391 169.090 1.00 48.62  ? 150 ILE A N   1 
ATOM   986  C CA  . ILE A 1 125 ? 140.616 164.096 169.752 1.00 48.62  ? 150 ILE A CA  1 
ATOM   987  C C   . ILE A 1 125 ? 139.566 165.130 169.369 1.00 48.62  ? 150 ILE A C   1 
ATOM   988  O O   . ILE A 1 125 ? 138.398 164.794 169.136 1.00 48.62  ? 150 ILE A O   1 
ATOM   989  C CB  . ILE A 1 125 ? 140.815 164.020 171.276 1.00 48.62  ? 150 ILE A CB  1 
ATOM   990  C CG1 . ILE A 1 125 ? 141.647 162.789 171.630 1.00 48.62  ? 150 ILE A CG1 1 
ATOM   991  C CG2 . ILE A 1 125 ? 139.477 163.976 171.992 1.00 48.62  ? 150 ILE A CG2 1 
ATOM   992  C CD1 . ILE A 1 125 ? 142.369 162.909 172.937 1.00 48.62  ? 150 ILE A CD1 1 
ATOM   993  N N   . TYR A 1 126 ? 139.966 166.402 169.285 1.00 52.02  ? 151 TYR A N   1 
ATOM   994  C CA  . TYR A 1 126 ? 139.030 167.425 168.825 1.00 52.02  ? 151 TYR A CA  1 
ATOM   995  C C   . TYR A 1 126 ? 138.572 167.150 167.398 1.00 52.02  ? 151 TYR A C   1 
ATOM   996  O O   . TYR A 1 126 ? 137.381 167.276 167.083 1.00 52.02  ? 151 TYR A O   1 
ATOM   997  C CB  . TYR A 1 126 ? 139.664 168.812 168.916 1.00 52.02  ? 151 TYR A CB  1 
ATOM   998  C CG  . TYR A 1 126 ? 138.895 169.868 168.152 1.00 52.02  ? 151 TYR A CG  1 
ATOM   999  C CD1 . TYR A 1 126 ? 137.752 170.445 168.688 1.00 52.02  ? 151 TYR A CD1 1 
ATOM   1000 C CD2 . TYR A 1 126 ? 139.305 170.280 166.891 1.00 52.02  ? 151 TYR A CD2 1 
ATOM   1001 C CE1 . TYR A 1 126 ? 137.043 171.405 167.993 1.00 52.02  ? 151 TYR A CE1 1 
ATOM   1002 C CE2 . TYR A 1 126 ? 138.603 171.239 166.189 1.00 52.02  ? 151 TYR A CE2 1 
ATOM   1003 C CZ  . TYR A 1 126 ? 137.474 171.798 166.745 1.00 52.02  ? 151 TYR A CZ  1 
ATOM   1004 O OH  . TYR A 1 126 ? 136.771 172.754 166.049 1.00 52.02  ? 151 TYR A OH  1 
ATOM   1005 N N   . CYS A 1 127 ? 139.511 166.795 166.517 1.00 56.28  ? 152 CYS A N   1 
ATOM   1006 C CA  . CYS A 1 127 ? 139.154 166.489 165.133 1.00 56.28  ? 152 CYS A CA  1 
ATOM   1007 C C   . CYS A 1 127 ? 138.164 165.335 165.060 1.00 56.28  ? 152 CYS A C   1 
ATOM   1008 O O   . CYS A 1 127 ? 137.193 165.389 164.298 1.00 56.28  ? 152 CYS A O   1 
ATOM   1009 C CB  . CYS A 1 127 ? 140.405 166.160 164.319 1.00 56.28  ? 152 CYS A CB  1 
ATOM   1010 S SG  . CYS A 1 127 ? 141.456 167.564 163.886 1.00 56.28  ? 152 CYS A SG  1 
ATOM   1011 N N   . MET A 1 128 ? 138.394 164.281 165.845 1.00 50.47  ? 153 MET A N   1 
ATOM   1012 C CA  . MET A 1 128 ? 137.487 163.137 165.827 1.00 50.47  ? 153 MET A CA  1 
ATOM   1013 C C   . MET A 1 128 ? 136.115 163.509 166.374 1.00 50.47  ? 153 MET A C   1 
ATOM   1014 O O   . MET A 1 128 ? 135.087 163.079 165.835 1.00 50.47  ? 153 MET A O   1 
ATOM   1015 C CB  . MET A 1 128 ? 138.087 161.976 166.620 1.00 50.47  ? 153 MET A CB  1 
ATOM   1016 C CG  . MET A 1 128 ? 137.076 160.922 167.042 1.00 50.47  ? 153 MET A CG  1 
ATOM   1017 S SD  . MET A 1 128 ? 136.314 160.075 165.646 1.00 50.47  ? 153 MET A SD  1 
ATOM   1018 C CE  . MET A 1 128 ? 137.720 159.186 164.987 1.00 50.47  ? 153 MET A CE  1 
ATOM   1019 N N   . ALA A 1 129 ? 136.076 164.310 167.442 1.00 50.61  ? 154 ALA A N   1 
ATOM   1020 C CA  . ALA A 1 129 ? 134.795 164.730 167.999 1.00 50.61  ? 154 ALA A CA  1 
ATOM   1021 C C   . ALA A 1 129 ? 134.019 165.588 167.009 1.00 50.61  ? 154 ALA A C   1 
ATOM   1022 O O   . ALA A 1 129 ? 132.786 165.515 166.944 1.00 50.61  ? 154 ALA A O   1 
ATOM   1023 C CB  . ALA A 1 129 ? 135.013 165.486 169.309 1.00 50.61  ? 154 ALA A CB  1 
ATOM   1024 N N   . GLN A 1 130 ? 134.724 166.406 166.226 1.00 58.56  ? 155 GLN A N   1 
ATOM   1025 C CA  . GLN A 1 130 ? 134.049 167.210 165.213 1.00 58.56  ? 155 GLN A CA  1 
ATOM   1026 C C   . GLN A 1 130 ? 133.590 166.350 164.042 1.00 58.56  ? 155 GLN A C   1 
ATOM   1027 O O   . GLN A 1 130 ? 132.530 166.600 163.457 1.00 58.56  ? 155 GLN A O   1 
ATOM   1028 C CB  . GLN A 1 130 ? 134.972 168.328 164.728 1.00 58.56  ? 155 GLN A CB  1 
ATOM   1029 C CG  . GLN A 1 130 ? 134.278 169.385 163.886 1.00 58.56  ? 155 GLN A CG  1 
ATOM   1030 C CD  . GLN A 1 130 ? 133.280 170.198 164.683 1.00 58.56  ? 155 GLN A CD  1 
ATOM   1031 O OE1 . GLN A 1 130 ? 132.096 170.250 164.350 1.00 58.56  ? 155 GLN A OE1 1 
ATOM   1032 N NE2 . GLN A 1 130 ? 133.754 170.840 165.744 1.00 58.56  ? 155 GLN A NE2 1 
ATOM   1033 N N   . LEU A 1 131 ? 134.374 165.328 163.690 1.00 57.96  ? 156 LEU A N   1 
ATOM   1034 C CA  . LEU A 1 131 ? 134.006 164.454 162.581 1.00 57.96  ? 156 LEU A CA  1 
ATOM   1035 C C   . LEU A 1 131 ? 132.809 163.579 162.927 1.00 57.96  ? 156 LEU A C   1 
ATOM   1036 O O   . LEU A 1 131 ? 132.011 163.248 162.043 1.00 57.96  ? 156 LEU A O   1 
ATOM   1037 C CB  . LEU A 1 131 ? 135.202 163.589 162.181 1.00 57.96  ? 156 LEU A CB  1 
ATOM   1038 C CG  . LEU A 1 131 ? 134.962 162.465 161.172 1.00 57.96  ? 156 LEU A CG  1 
ATOM   1039 C CD1 . LEU A 1 131 ? 134.447 163.024 159.859 1.00 57.96  ? 156 LEU A CD1 1 
ATOM   1040 C CD2 . LEU A 1 131 ? 136.234 161.668 160.952 1.00 57.96  ? 156 LEU A CD2 1 
ATOM   1041 N N   . LEU A 1 132 ? 132.669 163.192 164.197 1.00 67.37  ? 157 LEU A N   1 
ATOM   1042 C CA  . LEU A 1 132 ? 131.512 162.401 164.605 1.00 67.37  ? 157 LEU A CA  1 
ATOM   1043 C C   . LEU A 1 132 ? 130.217 163.151 164.320 1.00 67.37  ? 157 LEU A C   1 
ATOM   1044 O O   . LEU A 1 132 ? 129.401 162.719 163.498 1.00 67.37  ? 157 LEU A O   1 
ATOM   1045 C CB  . LEU A 1 132 ? 131.618 162.045 166.088 1.00 67.37  ? 157 LEU A CB  1 
ATOM   1046 C CG  . LEU A 1 132 ? 130.859 160.793 166.527 1.00 67.37  ? 157 LEU A CG  1 
ATOM   1047 C CD1 . LEU A 1 132 ? 131.088 159.658 165.541 1.00 67.37  ? 157 LEU A CD1 1 
ATOM   1048 C CD2 . LEU A 1 132 ? 131.265 160.379 167.934 1.00 67.37  ? 157 LEU A CD2 1 
ATOM   1049 N N   . ASP A 1 133 ? 130.023 164.290 164.983 1.00 73.42  ? 158 ASP A N   1 
ATOM   1050 C CA  . ASP A 1 133 ? 128.906 165.198 164.725 1.00 73.42  ? 158 ASP A CA  1 
ATOM   1051 C C   . ASP A 1 133 ? 127.562 164.475 164.835 1.00 73.42  ? 158 ASP A C   1 
ATOM   1052 O O   . ASP A 1 133 ? 126.797 164.367 163.875 1.00 73.42  ? 158 ASP A O   1 
ATOM   1053 C CB  . ASP A 1 133 ? 129.062 165.870 163.358 1.00 73.42  ? 158 ASP A CB  1 
ATOM   1054 C CG  . ASP A 1 133 ? 128.214 167.119 163.221 1.00 73.42  ? 158 ASP A CG  1 
ATOM   1055 O OD1 . ASP A 1 133 ? 127.631 167.559 164.234 1.00 73.42  ? 158 ASP A OD1 1 
ATOM   1056 O OD2 . ASP A 1 133 ? 128.132 167.662 162.100 1.00 73.42  ? 158 ASP A OD2 1 
ATOM   1057 N N   . ASN A 1 134 ? 127.287 163.976 166.035 1.00 76.12  ? 159 ASN A N   1 
ATOM   1058 C CA  . ASN A 1 134 ? 126.025 163.296 166.303 1.00 76.12  ? 159 ASN A CA  1 
ATOM   1059 C C   . ASN A 1 134 ? 125.374 163.829 167.575 1.00 76.12  ? 159 ASN A C   1 
ATOM   1060 O O   . ASN A 1 134 ? 124.377 163.285 168.048 1.00 76.12  ? 159 ASN A O   1 
ATOM   1061 C CB  . ASN A 1 134 ? 126.239 161.785 166.415 1.00 76.12  ? 159 ASN A CB  1 
ATOM   1062 C CG  . ASN A 1 134 ? 126.751 161.172 165.128 1.00 76.12  ? 159 ASN A CG  1 
ATOM   1063 O OD1 . ASN A 1 134 ? 127.936 160.867 165.003 1.00 76.12  ? 159 ASN A OD1 1 
ATOM   1064 N ND2 . ASN A 1 134 ? 125.859 160.992 164.161 1.00 76.12  ? 159 ASN A ND2 1 
ATOM   1065 N N   . THR A 1 154 ? 148.279 170.300 200.584 1.00 114.49 ? 179 THR A N   1 
ATOM   1066 C CA  . THR A 1 154 ? 149.730 170.195 200.689 1.00 114.49 ? 179 THR A CA  1 
ATOM   1067 C C   . THR A 1 154 ? 150.381 171.573 200.657 1.00 114.49 ? 179 THR A C   1 
ATOM   1068 O O   . THR A 1 154 ? 150.725 172.077 199.587 1.00 114.49 ? 179 THR A O   1 
ATOM   1069 C CB  . THR A 1 154 ? 150.318 169.333 199.557 1.00 114.49 ? 179 THR A CB  1 
ATOM   1070 O OG1 . THR A 1 154 ? 150.090 169.975 198.296 1.00 114.49 ? 179 THR A OG1 1 
ATOM   1071 C CG2 . THR A 1 154 ? 149.670 167.957 199.544 1.00 114.49 ? 179 THR A CG2 1 
ATOM   1072 N N   . PRO A 1 155 ? 150.545 172.186 201.831 1.00 113.88 ? 180 PRO A N   1 
ATOM   1073 C CA  . PRO A 1 155 ? 151.180 173.510 201.891 1.00 113.88 ? 180 PRO A CA  1 
ATOM   1074 C C   . PRO A 1 155 ? 152.639 173.473 201.466 1.00 113.88 ? 180 PRO A C   1 
ATOM   1075 O O   . PRO A 1 155 ? 153.072 174.273 200.631 1.00 113.88 ? 180 PRO A O   1 
ATOM   1076 C CB  . PRO A 1 155 ? 151.036 173.905 203.368 1.00 113.88 ? 180 PRO A CB  1 
ATOM   1077 C CG  . PRO A 1 155 ? 149.955 173.017 203.909 1.00 113.88 ? 180 PRO A CG  1 
ATOM   1078 C CD  . PRO A 1 155 ? 150.081 171.735 203.152 1.00 113.88 ? 180 PRO A CD  1 
ATOM   1079 N N   . ALA A 1 156 ? 153.406 172.545 202.037 1.00 103.18 ? 181 ALA A N   1 
ATOM   1080 C CA  . ALA A 1 156 ? 154.820 172.407 201.728 1.00 103.18 ? 181 ALA A CA  1 
ATOM   1081 C C   . ALA A 1 156 ? 155.201 170.935 201.740 1.00 103.18 ? 181 ALA A C   1 
ATOM   1082 O O   . ALA A 1 156 ? 154.756 170.178 202.608 1.00 103.18 ? 181 ALA A O   1 
ATOM   1083 C CB  . ALA A 1 156 ? 155.691 173.182 202.725 1.00 103.18 ? 181 ALA A CB  1 
ATOM   1084 N N   . SER A 1 157 ? 156.025 170.537 200.776 1.00 83.71  ? 182 SER A N   1 
ATOM   1085 C CA  . SER A 1 157 ? 156.492 169.166 200.655 1.00 83.71  ? 182 SER A CA  1 
ATOM   1086 C C   . SER A 1 157 ? 158.014 169.132 200.683 1.00 83.71  ? 182 SER A C   1 
ATOM   1087 O O   . SER A 1 157 ? 158.685 170.157 200.534 1.00 83.71  ? 182 SER A O   1 
ATOM   1088 C CB  . SER A 1 157 ? 155.973 168.513 199.367 1.00 83.71  ? 182 SER A CB  1 
ATOM   1089 O OG  . SER A 1 157 ? 154.649 168.038 199.536 1.00 83.71  ? 182 SER A OG  1 
ATOM   1090 N N   . ASP A 1 158 ? 158.554 167.933 200.876 1.00 78.25  ? 183 ASP A N   1 
ATOM   1091 C CA  . ASP A 1 158 ? 159.994 167.759 200.984 1.00 78.25  ? 183 ASP A CA  1 
ATOM   1092 C C   . ASP A 1 158 ? 160.630 167.570 199.612 1.00 78.25  ? 183 ASP A C   1 
ATOM   1093 O O   . ASP A 1 158 ? 159.994 167.098 198.661 1.00 78.25  ? 183 ASP A O   1 
ATOM   1094 C CB  . ASP A 1 158 ? 160.325 166.565 201.879 1.00 78.25  ? 183 ASP A CB  1 
ATOM   1095 C CG  . ASP A 1 158 ? 161.715 166.654 202.477 1.00 78.25  ? 183 ASP A CG  1 
ATOM   1096 O OD1 . ASP A 1 158 ? 162.435 167.626 202.165 1.00 78.25  ? 183 ASP A OD1 1 
ATOM   1097 O OD2 . ASP A 1 158 ? 162.087 165.753 203.257 1.00 78.25  ? 183 ASP A OD2 1 
ATOM   1098 N N   . ALA A 1 159 ? 161.910 167.946 199.522 1.00 67.82  ? 184 ALA A N   1 
ATOM   1099 C CA  . ALA A 1 159 ? 162.650 167.792 198.275 1.00 67.82  ? 184 ALA A CA  1 
ATOM   1100 C C   . ALA A 1 159 ? 162.788 166.329 197.881 1.00 67.82  ? 184 ALA A C   1 
ATOM   1101 O O   . ALA A 1 159 ? 162.970 166.020 196.698 1.00 67.82  ? 184 ALA A O   1 
ATOM   1102 C CB  . ALA A 1 159 ? 164.028 168.441 198.396 1.00 67.82  ? 184 ALA A CB  1 
ATOM   1103 N N   . PHE A 1 160 ? 162.711 165.416 198.849 1.00 61.22  ? 185 PHE A N   1 
ATOM   1104 C CA  . PHE A 1 160 ? 162.729 163.993 198.549 1.00 61.22  ? 185 PHE A CA  1 
ATOM   1105 C C   . PHE A 1 160 ? 161.341 163.422 198.306 1.00 61.22  ? 185 PHE A C   1 
ATOM   1106 O O   . PHE A 1 160 ? 161.219 162.394 197.632 1.00 61.22  ? 185 PHE A O   1 
ATOM   1107 C CB  . PHE A 1 160 ? 163.403 163.215 199.682 1.00 61.22  ? 185 PHE A CB  1 
ATOM   1108 C CG  . PHE A 1 160 ? 163.708 161.787 199.336 1.00 61.22  ? 185 PHE A CG  1 
ATOM   1109 C CD1 . PHE A 1 160 ? 164.808 161.470 198.559 1.00 61.22  ? 185 PHE A CD1 1 
ATOM   1110 C CD2 . PHE A 1 160 ? 162.893 160.763 199.784 1.00 61.22  ? 185 PHE A CD2 1 
ATOM   1111 C CE1 . PHE A 1 160 ? 165.090 160.158 198.238 1.00 61.22  ? 185 PHE A CE1 1 
ATOM   1112 C CE2 . PHE A 1 160 ? 163.170 159.450 199.465 1.00 61.22  ? 185 PHE A CE2 1 
ATOM   1113 C CZ  . PHE A 1 160 ? 164.270 159.147 198.691 1.00 61.22  ? 185 PHE A CZ  1 
ATOM   1114 N N   . GLN A 1 161 ? 160.296 164.059 198.835 1.00 64.75  ? 186 GLN A N   1 
ATOM   1115 C CA  . GLN A 1 161 ? 158.938 163.589 198.588 1.00 64.75  ? 186 GLN A CA  1 
ATOM   1116 C C   . GLN A 1 161 ? 158.431 164.019 197.217 1.00 64.75  ? 186 GLN A C   1 
ATOM   1117 O O   . GLN A 1 161 ? 157.621 163.307 196.606 1.00 64.75  ? 186 GLN A O   1 
ATOM   1118 C CB  . GLN A 1 161 ? 158.000 164.099 199.682 1.00 64.75  ? 186 GLN A CB  1 
ATOM   1119 C CG  . GLN A 1 161 ? 156.608 163.495 199.639 1.00 64.75  ? 186 GLN A CG  1 
ATOM   1120 C CD  . GLN A 1 161 ? 156.606 162.013 199.954 1.00 64.75  ? 186 GLN A CD  1 
ATOM   1121 O OE1 . GLN A 1 161 ? 155.817 161.250 199.398 1.00 64.75  ? 186 GLN A OE1 1 
ATOM   1122 N NE2 . GLN A 1 161 ? 157.490 161.599 200.854 1.00 64.75  ? 186 GLN A NE2 1 
ATOM   1123 N N   . ARG A 1 162 ? 158.894 165.170 196.722 1.00 66.69  ? 187 ARG A N   1 
ATOM   1124 C CA  . ARG A 1 162 ? 158.455 165.639 195.412 1.00 66.69  ? 187 ARG A CA  1 
ATOM   1125 C C   . ARG A 1 162 ? 158.869 164.673 194.306 1.00 66.69  ? 187 ARG A C   1 
ATOM   1126 O O   . ARG A 1 162 ? 158.106 164.434 193.361 1.00 66.69  ? 187 ARG A O   1 
ATOM   1127 C CB  . ARG A 1 162 ? 159.012 167.036 195.145 1.00 66.69  ? 187 ARG A CB  1 
ATOM   1128 C CG  . ARG A 1 162 ? 158.321 168.131 195.938 1.00 66.69  ? 187 ARG A CG  1 
ATOM   1129 C CD  . ARG A 1 162 ? 158.966 169.484 195.693 1.00 66.69  ? 187 ARG A CD  1 
ATOM   1130 N NE  . ARG A 1 162 ? 158.016 170.578 195.868 1.00 66.69  ? 187 ARG A NE  1 
ATOM   1131 C CZ  . ARG A 1 162 ? 157.824 171.226 197.012 1.00 66.69  ? 187 ARG A CZ  1 
ATOM   1132 N NH1 . ARG A 1 162 ? 158.518 170.890 198.091 1.00 66.69  ? 187 ARG A NH1 1 
ATOM   1133 N NH2 . ARG A 1 162 ? 156.938 172.210 197.078 1.00 66.69  ? 187 ARG A NH2 1 
ATOM   1134 N N   . LYS A 1 163 ? 160.072 164.104 194.410 1.00 55.05  ? 188 LYS A N   1 
ATOM   1135 C CA  . LYS A 1 163 ? 160.537 163.156 193.401 1.00 55.05  ? 188 LYS A CA  1 
ATOM   1136 C C   . LYS A 1 163 ? 159.655 161.914 193.367 1.00 55.05  ? 188 LYS A C   1 
ATOM   1137 O O   . LYS A 1 163 ? 159.265 161.441 192.291 1.00 55.05  ? 188 LYS A O   1 
ATOM   1138 C CB  . LYS A 1 163 ? 161.991 162.775 193.674 1.00 55.05  ? 188 LYS A CB  1 
ATOM   1139 C CG  . LYS A 1 163 ? 162.887 163.947 194.023 1.00 55.05  ? 188 LYS A CG  1 
ATOM   1140 C CD  . LYS A 1 163 ? 164.297 163.474 194.326 1.00 55.05  ? 188 LYS A CD  1 
ATOM   1141 C CE  . LYS A 1 163 ? 165.197 164.629 194.720 1.00 55.05  ? 188 LYS A CE  1 
ATOM   1142 N NZ  . LYS A 1 163 ? 166.610 164.190 194.879 1.00 55.05  ? 188 LYS A NZ  1 
ATOM   1143 N N   . LEU A 1 164 ? 159.339 161.366 194.542 1.00 57.99  ? 189 LEU A N   1 
ATOM   1144 C CA  . LEU A 1 164 ? 158.470 160.195 194.603 1.00 57.99  ? 189 LEU A CA  1 
ATOM   1145 C C   . LEU A 1 164 ? 157.084 160.513 194.060 1.00 57.99  ? 189 LEU A C   1 
ATOM   1146 O O   . LEU A 1 164 ? 156.475 159.687 193.367 1.00 57.99  ? 189 LEU A O   1 
ATOM   1147 C CB  . LEU A 1 164 ? 158.380 159.684 196.040 1.00 57.99  ? 189 LEU A CB  1 
ATOM   1148 C CG  . LEU A 1 164 ? 159.328 158.550 196.435 1.00 57.99  ? 189 LEU A CG  1 
ATOM   1149 C CD1 . LEU A 1 164 ? 160.778 158.948 196.214 1.00 57.99  ? 189 LEU A CD1 1 
ATOM   1150 C CD2 . LEU A 1 164 ? 159.097 158.146 197.882 1.00 57.99  ? 189 LEU A CD2 1 
ATOM   1151 N N   . GLU A 1 165 ? 156.570 161.708 194.360 1.00 59.22  ? 190 GLU A N   1 
ATOM   1152 C CA  . GLU A 1 165 ? 155.263 162.095 193.839 1.00 59.22  ? 190 GLU A CA  1 
ATOM   1153 C C   . GLU A 1 165 ? 155.279 162.157 192.317 1.00 59.22  ? 190 GLU A C   1 
ATOM   1154 O O   . GLU A 1 165 ? 154.361 161.659 191.651 1.00 59.22  ? 190 GLU A O   1 
ATOM   1155 C CB  . GLU A 1 165 ? 154.838 163.437 194.432 1.00 59.22  ? 190 GLU A CB  1 
ATOM   1156 C CG  . GLU A 1 165 ? 153.389 163.804 194.156 1.00 59.22  ? 190 GLU A CG  1 
ATOM   1157 C CD  . GLU A 1 165 ? 152.420 162.712 194.571 1.00 59.22  ? 190 GLU A CD  1 
ATOM   1158 O OE1 . GLU A 1 165 ? 152.059 161.875 193.717 1.00 59.22  ? 190 GLU A OE1 1 
ATOM   1159 O OE2 . GLU A 1 165 ? 152.020 162.692 195.754 1.00 59.22  ? 190 GLU A OE2 1 
ATOM   1160 N N   . GLY A 1 166 ? 156.323 162.762 191.746 1.00 54.99  ? 191 GLY A N   1 
ATOM   1161 C CA  . GLY A 1 166 ? 156.435 162.810 190.297 1.00 54.99  ? 191 GLY A CA  1 
ATOM   1162 C C   . GLY A 1 166 ? 156.539 161.431 189.671 1.00 54.99  ? 191 GLY A C   1 
ATOM   1163 O O   . GLY A 1 166 ? 155.936 161.163 188.627 1.00 54.99  ? 191 GLY A O   1 
ATOM   1164 N N   . CYS A 1 167 ? 157.301 160.535 190.304 1.00 56.16  ? 192 CYS A N   1 
ATOM   1165 C CA  . CYS A 1 167 ? 157.445 159.183 189.774 1.00 56.16  ? 192 CYS A CA  1 
ATOM   1166 C C   . CYS A 1 167 ? 156.114 158.439 189.786 1.00 56.16  ? 192 CYS A C   1 
ATOM   1167 O O   . CYS A 1 167 ? 155.751 157.773 188.803 1.00 56.16  ? 192 CYS A O   1 
ATOM   1168 C CB  . CYS A 1 167 ? 158.499 158.421 190.578 1.00 56.16  ? 192 CYS A CB  1 
ATOM   1169 S SG  . CYS A 1 167 ? 159.242 157.022 189.717 1.00 56.16  ? 192 CYS A SG  1 
ATOM   1170 N N   . ARG A 1 168 ? 155.366 158.546 190.887 1.00 55.73  ? 193 ARG A N   1 
ATOM   1171 C CA  . ARG A 1 168 ? 154.056 157.904 190.953 1.00 55.73  ? 193 ARG A CA  1 
ATOM   1172 C C   . ARG A 1 168 ? 153.102 158.488 189.918 1.00 55.73  ? 193 ARG A C   1 
ATOM   1173 O O   . ARG A 1 168 ? 152.325 157.753 189.291 1.00 55.73  ? 193 ARG A O   1 
ATOM   1174 C CB  . ARG A 1 168 ? 153.473 158.043 192.358 1.00 55.73  ? 193 ARG A CB  1 
ATOM   1175 C CG  . ARG A 1 168 ? 154.296 157.369 193.439 1.00 55.73  ? 193 ARG A CG  1 
ATOM   1176 C CD  . ARG A 1 168 ? 153.879 157.841 194.820 1.00 55.73  ? 193 ARG A CD  1 
ATOM   1177 N NE  . ARG A 1 168 ? 154.725 157.275 195.866 1.00 55.73  ? 193 ARG A NE  1 
ATOM   1178 C CZ  . ARG A 1 168 ? 154.429 156.176 196.551 1.00 55.73  ? 193 ARG A CZ  1 
ATOM   1179 N NH1 . ARG A 1 168 ? 155.258 155.732 197.486 1.00 55.73  ? 193 ARG A NH1 1 
ATOM   1180 N NH2 . ARG A 1 168 ? 153.303 155.521 196.303 1.00 55.73  ? 193 ARG A NH2 1 
ATOM   1181 N N   . PHE A 1 169 ? 153.146 159.809 189.724 1.00 50.72  ? 194 PHE A N   1 
ATOM   1182 C CA  . PHE A 1 169 ? 152.296 160.436 188.717 1.00 50.72  ? 194 PHE A CA  1 
ATOM   1183 C C   . PHE A 1 169 ? 152.622 159.918 187.322 1.00 50.72  ? 194 PHE A C   1 
ATOM   1184 O O   . PHE A 1 169 ? 151.716 159.633 186.529 1.00 50.72  ? 194 PHE A O   1 
ATOM   1185 C CB  . PHE A 1 169 ? 152.448 161.956 188.782 1.00 50.72  ? 194 PHE A CB  1 
ATOM   1186 C CG  . PHE A 1 169 ? 152.172 162.653 187.480 1.00 50.72  ? 194 PHE A CG  1 
ATOM   1187 C CD1 . PHE A 1 169 ? 150.883 162.742 186.985 1.00 50.72  ? 194 PHE A CD1 1 
ATOM   1188 C CD2 . PHE A 1 169 ? 153.203 163.230 186.758 1.00 50.72  ? 194 PHE A CD2 1 
ATOM   1189 C CE1 . PHE A 1 169 ? 150.629 163.385 185.790 1.00 50.72  ? 194 PHE A CE1 1 
ATOM   1190 C CE2 . PHE A 1 169 ? 152.954 163.875 185.564 1.00 50.72  ? 194 PHE A CE2 1 
ATOM   1191 C CZ  . PHE A 1 169 ? 151.666 163.952 185.079 1.00 50.72  ? 194 PHE A CZ  1 
ATOM   1192 N N   . LEU A 1 170 ? 153.912 159.782 187.004 1.00 46.81  ? 195 LEU A N   1 
ATOM   1193 C CA  . LEU A 1 170 ? 154.291 159.283 185.685 1.00 46.81  ? 195 LEU A CA  1 
ATOM   1194 C C   . LEU A 1 170 ? 153.857 157.834 185.491 1.00 46.81  ? 195 LEU A C   1 
ATOM   1195 O O   . LEU A 1 170 ? 153.400 157.457 184.403 1.00 46.81  ? 195 LEU A O   1 
ATOM   1196 C CB  . LEU A 1 170 ? 155.797 159.428 185.481 1.00 46.81  ? 195 LEU A CB  1 
ATOM   1197 C CG  . LEU A 1 170 ? 156.262 160.843 185.140 1.00 46.81  ? 195 LEU A CG  1 
ATOM   1198 C CD1 . LEU A 1 170 ? 157.753 160.866 184.890 1.00 46.81  ? 195 LEU A CD1 1 
ATOM   1199 C CD2 . LEU A 1 170 ? 155.511 161.370 183.932 1.00 46.81  ? 195 LEU A CD2 1 
ATOM   1200 N N   . HIS A 1 171 ? 153.986 157.006 186.531 1.00 55.12  ? 196 HIS A N   1 
ATOM   1201 C CA  . HIS A 1 171 ? 153.536 155.621 186.412 1.00 55.12  ? 196 HIS A CA  1 
ATOM   1202 C C   . HIS A 1 171 ? 152.029 155.547 186.184 1.00 55.12  ? 196 HIS A C   1 
ATOM   1203 O O   . HIS A 1 171 ? 151.553 154.763 185.348 1.00 55.12  ? 196 HIS A O   1 
ATOM   1204 C CB  . HIS A 1 171 ? 153.930 154.828 187.656 1.00 55.12  ? 196 HIS A CB  1 
ATOM   1205 C CG  . HIS A 1 171 ? 153.750 153.349 187.509 1.00 55.12  ? 196 HIS A CG  1 
ATOM   1206 N ND1 . HIS A 1 171 ? 152.580 152.705 187.846 1.00 55.12  ? 196 HIS A ND1 1 
ATOM   1207 C CD2 . HIS A 1 171 ? 154.591 152.390 187.056 1.00 55.12  ? 196 HIS A CD2 1 
ATOM   1208 C CE1 . HIS A 1 171 ? 152.708 151.411 187.610 1.00 55.12  ? 196 HIS A CE1 1 
ATOM   1209 N NE2 . HIS A 1 171 ? 153.919 151.194 187.130 1.00 55.12  ? 196 HIS A NE2 1 
ATOM   1210 N N   . GLY A 1 172 ? 151.261 156.354 186.919 1.00 50.16  ? 197 GLY A N   1 
ATOM   1211 C CA  . GLY A 1 172 ? 149.826 156.395 186.689 1.00 50.16  ? 197 GLY A CA  1 
ATOM   1212 C C   . GLY A 1 172 ? 149.476 156.861 185.288 1.00 50.16  ? 197 GLY A C   1 
ATOM   1213 O O   . GLY A 1 172 ? 148.547 156.342 184.662 1.00 50.16  ? 197 GLY A O   1 
ATOM   1214 N N   . TYR A 1 173 ? 150.218 157.846 184.777 1.00 44.74  ? 198 TYR A N   1 
ATOM   1215 C CA  . TYR A 1 173 ? 149.984 158.317 183.416 1.00 44.74  ? 198 TYR A CA  1 
ATOM   1216 C C   . TYR A 1 173 ? 150.248 157.215 182.399 1.00 44.74  ? 198 TYR A C   1 
ATOM   1217 O O   . TYR A 1 173 ? 149.511 157.075 181.417 1.00 44.74  ? 198 TYR A O   1 
ATOM   1218 C CB  . TYR A 1 173 ? 150.861 159.535 183.127 1.00 44.74  ? 198 TYR A CB  1 
ATOM   1219 C CG  . TYR A 1 173 ? 150.935 159.902 181.664 1.00 44.74  ? 198 TYR A CG  1 
ATOM   1220 C CD1 . TYR A 1 173 ? 149.870 160.525 181.031 1.00 44.74  ? 198 TYR A CD1 1 
ATOM   1221 C CD2 . TYR A 1 173 ? 152.071 159.627 180.917 1.00 44.74  ? 198 TYR A CD2 1 
ATOM   1222 C CE1 . TYR A 1 173 ? 149.933 160.863 179.694 1.00 44.74  ? 198 TYR A CE1 1 
ATOM   1223 C CE2 . TYR A 1 173 ? 152.141 159.960 179.581 1.00 44.74  ? 198 TYR A CE2 1 
ATOM   1224 C CZ  . TYR A 1 173 ? 151.072 160.578 178.975 1.00 44.74  ? 198 TYR A CZ  1 
ATOM   1225 O OH  . TYR A 1 173 ? 151.143 160.911 177.643 1.00 44.74  ? 198 TYR A OH  1 
ATOM   1226 N N   . HIS A 1 174 ? 151.296 156.418 182.620 1.00 42.50  ? 199 HIS A N   1 
ATOM   1227 C CA  . HIS A 1 174 ? 151.579 155.311 181.710 1.00 42.50  ? 199 HIS A CA  1 
ATOM   1228 C C   . HIS A 1 174 ? 150.475 154.262 181.751 1.00 42.50  ? 199 HIS A C   1 
ATOM   1229 O O   . HIS A 1 174 ? 150.077 153.726 180.707 1.00 42.50  ? 199 HIS A O   1 
ATOM   1230 C CB  . HIS A 1 174 ? 152.926 154.686 182.052 1.00 42.50  ? 199 HIS A CB  1 
ATOM   1231 C CG  . HIS A 1 174 ? 154.086 155.410 181.451 1.00 42.50  ? 199 HIS A CG  1 
ATOM   1232 N ND1 . HIS A 1 174 ? 154.059 155.911 180.169 1.00 42.50  ? 199 HIS A ND1 1 
ATOM   1233 C CD2 . HIS A 1 174 ? 155.299 155.731 181.957 1.00 42.50  ? 199 HIS A CD2 1 
ATOM   1234 C CE1 . HIS A 1 174 ? 155.210 156.502 179.907 1.00 42.50  ? 199 HIS A CE1 1 
ATOM   1235 N NE2 . HIS A 1 174 ? 155.979 156.410 180.977 1.00 42.50  ? 199 HIS A NE2 1 
ATOM   1236 N N   . ARG A 1 175 ? 149.972 153.951 182.948 1.00 49.95  ? 200 ARG A N   1 
ATOM   1237 C CA  . ARG A 1 175 ? 148.851 153.020 183.048 1.00 49.95  ? 200 ARG A CA  1 
ATOM   1238 C C   . ARG A 1 175 ? 147.631 153.549 182.301 1.00 49.95  ? 200 ARG A C   1 
ATOM   1239 O O   . ARG A 1 175 ? 146.946 152.797 181.592 1.00 49.95  ? 200 ARG A O   1 
ATOM   1240 C CB  . ARG A 1 175 ? 148.514 152.757 184.515 1.00 49.95  ? 200 ARG A CB  1 
ATOM   1241 C CG  . ARG A 1 175 ? 147.855 151.411 184.780 1.00 49.95  ? 200 ARG A CG  1 
ATOM   1242 C CD  . ARG A 1 175 ? 146.353 151.467 184.547 1.00 49.95  ? 200 ARG A CD  1 
ATOM   1243 N NE  . ARG A 1 175 ? 145.752 152.647 185.160 1.00 49.95  ? 200 ARG A NE  1 
ATOM   1244 C CZ  . ARG A 1 175 ? 144.470 152.977 185.049 1.00 49.95  ? 200 ARG A CZ  1 
ATOM   1245 N NH1 . ARG A 1 175 ? 143.644 152.215 184.346 1.00 49.95  ? 200 ARG A NH1 1 
ATOM   1246 N NH2 . ARG A 1 175 ? 144.012 154.071 185.641 1.00 49.95  ? 200 ARG A NH2 1 
ATOM   1247 N N   . PHE A 1 176 ? 147.346 154.846 182.446 1.00 48.64  ? 201 PHE A N   1 
ATOM   1248 C CA  . PHE A 1 176 ? 146.203 155.431 181.752 1.00 48.64  ? 201 PHE A CA  1 
ATOM   1249 C C   . PHE A 1 176 ? 146.393 155.389 180.241 1.00 48.64  ? 201 PHE A C   1 
ATOM   1250 O O   . PHE A 1 176 ? 145.434 155.162 179.492 1.00 48.64  ? 201 PHE A O   1 
ATOM   1251 C CB  . PHE A 1 176 ? 145.981 156.866 182.224 1.00 48.64  ? 201 PHE A CB  1 
ATOM   1252 C CG  . PHE A 1 176 ? 144.833 157.553 181.548 1.00 48.64  ? 201 PHE A CG  1 
ATOM   1253 C CD1 . PHE A 1 176 ? 143.533 157.126 181.757 1.00 48.64  ? 201 PHE A CD1 1 
ATOM   1254 C CD2 . PHE A 1 176 ? 145.053 158.629 180.705 1.00 48.64  ? 201 PHE A CD2 1 
ATOM   1255 C CE1 . PHE A 1 176 ? 142.474 157.757 181.137 1.00 48.64  ? 201 PHE A CE1 1 
ATOM   1256 C CE2 . PHE A 1 176 ? 143.998 159.264 180.083 1.00 48.64  ? 201 PHE A CE2 1 
ATOM   1257 C CZ  . PHE A 1 176 ? 142.707 158.828 180.299 1.00 48.64  ? 201 PHE A CZ  1 
ATOM   1258 N N   . MET A 1 177 ? 147.624 155.607 179.775 1.00 47.75  ? 202 MET A N   1 
ATOM   1259 C CA  . MET A 1 177 ? 147.890 155.523 178.342 1.00 47.75  ? 202 MET A CA  1 
ATOM   1260 C C   . MET A 1 177 ? 147.674 154.107 177.827 1.00 47.75  ? 202 MET A C   1 
ATOM   1261 O O   . MET A 1 177 ? 147.118 153.913 176.741 1.00 47.75  ? 202 MET A O   1 
ATOM   1262 C CB  . MET A 1 177 ? 149.311 155.996 178.037 1.00 47.75  ? 202 MET A CB  1 
ATOM   1263 C CG  . MET A 1 177 ? 149.482 157.503 178.082 1.00 47.75  ? 202 MET A CG  1 
ATOM   1264 S SD  . MET A 1 177 ? 148.235 158.370 177.114 1.00 47.75  ? 202 MET A SD  1 
ATOM   1265 C CE  . MET A 1 177 ? 148.538 157.689 175.487 1.00 47.75  ? 202 MET A CE  1 
ATOM   1266 N N   . HIS A 1 178 ? 148.107 153.103 178.593 1.00 54.92  ? 203 HIS A N   1 
ATOM   1267 C CA  . HIS A 1 178 ? 147.845 151.719 178.203 1.00 54.92  ? 203 HIS A CA  1 
ATOM   1268 C C   . HIS A 1 178 ? 146.347 151.453 178.111 1.00 54.92  ? 203 HIS A C   1 
ATOM   1269 O O   . HIS A 1 178 ? 145.868 150.825 177.156 1.00 54.92  ? 203 HIS A O   1 
ATOM   1270 C CB  . HIS A 1 178 ? 148.502 150.756 179.191 1.00 54.92  ? 203 HIS A CB  1 
ATOM   1271 C CG  . HIS A 1 178 ? 147.886 149.390 179.205 1.00 54.92  ? 203 HIS A CG  1 
ATOM   1272 N ND1 . HIS A 1 178 ? 148.326 148.367 178.394 1.00 54.92  ? 203 HIS A ND1 1 
ATOM   1273 C CD2 . HIS A 1 178 ? 146.869 148.878 179.937 1.00 54.92  ? 203 HIS A CD2 1 
ATOM   1274 C CE1 . HIS A 1 178 ? 147.603 147.285 178.621 1.00 54.92  ? 203 HIS A CE1 1 
ATOM   1275 N NE2 . HIS A 1 178 ? 146.711 147.568 179.554 1.00 54.92  ? 203 HIS A NE2 1 
ATOM   1276 N N   . SER A 1 179 ? 145.592 151.924 179.106 1.00 52.64  ? 204 SER A N   1 
ATOM   1277 C CA  . SER A 1 179 ? 144.148 151.707 179.104 1.00 52.64  ? 204 SER A CA  1 
ATOM   1278 C C   . SER A 1 179 ? 143.494 152.349 177.885 1.00 52.64  ? 204 SER A C   1 
ATOM   1279 O O   . SER A 1 179 ? 142.671 151.723 177.204 1.00 52.64  ? 204 SER A O   1 
ATOM   1280 C CB  . SER A 1 179 ? 143.533 152.251 180.393 1.00 52.64  ? 204 SER A CB  1 
ATOM   1281 O OG  . SER A 1 179 ? 142.231 151.729 180.589 1.00 52.64  ? 204 SER A OG  1 
ATOM   1282 N N   . VAL A 1 180 ? 143.853 153.601 177.590 1.00 50.32  ? 205 VAL A N   1 
ATOM   1283 C CA  . VAL A 1 180 ? 143.220 154.288 176.468 1.00 50.32  ? 205 VAL A CA  1 
ATOM   1284 C C   . VAL A 1 180 ? 143.648 153.669 175.142 1.00 50.32  ? 205 VAL A C   1 
ATOM   1285 O O   . VAL A 1 180 ? 142.858 153.618 174.192 1.00 50.32  ? 205 VAL A O   1 
ATOM   1286 C CB  . VAL A 1 180 ? 143.505 155.803 176.518 1.00 50.32  ? 205 VAL A CB  1 
ATOM   1287 C CG1 . VAL A 1 180 ? 144.951 156.109 176.172 1.00 50.32  ? 205 VAL A CG1 1 
ATOM   1288 C CG2 . VAL A 1 180 ? 142.566 156.546 175.586 1.00 50.32  ? 205 VAL A CG2 1 
ATOM   1289 N N   . GLY A 1 181 ? 144.881 153.161 175.056 1.00 52.31  ? 206 GLY A N   1 
ATOM   1290 C CA  . GLY A 1 181 ? 145.297 152.476 173.845 1.00 52.31  ? 206 GLY A CA  1 
ATOM   1291 C C   . GLY A 1 181 ? 144.514 151.200 173.609 1.00 52.31  ? 206 GLY A C   1 
ATOM   1292 O O   . GLY A 1 181 ? 144.088 150.921 172.483 1.00 52.31  ? 206 GLY A O   1 
ATOM   1293 N N   . ARG A 1 182 ? 144.306 150.410 174.666 1.00 58.23  ? 207 ARG A N   1 
ATOM   1294 C CA  . ARG A 1 182 ? 143.488 149.209 174.526 1.00 58.23  ? 207 ARG A CA  1 
ATOM   1295 C C   . ARG A 1 182 ? 142.055 149.561 174.143 1.00 58.23  ? 207 ARG A C   1 
ATOM   1296 O O   . ARG A 1 182 ? 141.445 148.885 173.302 1.00 58.23  ? 207 ARG A O   1 
ATOM   1297 C CB  . ARG A 1 182 ? 143.514 148.395 175.819 1.00 58.23  ? 207 ARG A CB  1 
ATOM   1298 C CG  . ARG A 1 182 ? 144.879 147.825 176.177 1.00 58.23  ? 207 ARG A CG  1 
ATOM   1299 C CD  . ARG A 1 182 ? 145.605 147.285 174.953 1.00 58.23  ? 207 ARG A CD  1 
ATOM   1300 N NE  . ARG A 1 182 ? 146.644 148.200 174.488 1.00 58.23  ? 207 ARG A NE  1 
ATOM   1301 C CZ  . ARG A 1 182 ? 147.502 147.924 173.511 1.00 58.23  ? 207 ARG A CZ  1 
ATOM   1302 N NH1 . ARG A 1 182 ? 147.448 146.754 172.890 1.00 58.23  ? 207 ARG A NH1 1 
ATOM   1303 N NH2 . ARG A 1 182 ? 148.414 148.818 173.156 1.00 58.23  ? 207 ARG A NH2 1 
ATOM   1304 N N   . VAL A 1 183 ? 141.506 150.624 174.737 1.00 54.19  ? 208 VAL A N   1 
ATOM   1305 C CA  . VAL A 1 183 ? 140.140 151.027 174.410 1.00 54.19  ? 208 VAL A CA  1 
ATOM   1306 C C   . VAL A 1 183 ? 140.039 151.419 172.940 1.00 54.19  ? 208 VAL A C   1 
ATOM   1307 O O   . VAL A 1 183 ? 139.112 151.007 172.235 1.00 54.19  ? 208 VAL A O   1 
ATOM   1308 C CB  . VAL A 1 183 ? 139.674 152.166 175.334 1.00 54.19  ? 208 VAL A CB  1 
ATOM   1309 C CG1 . VAL A 1 183 ? 138.395 152.789 174.802 1.00 54.19  ? 208 VAL A CG1 1 
ATOM   1310 C CG2 . VAL A 1 183 ? 139.457 151.644 176.743 1.00 54.19  ? 208 VAL A CG2 1 
ATOM   1311 N N   . PHE A 1 184 ? 140.998 152.212 172.454 1.00 53.06  ? 209 PHE A N   1 
ATOM   1312 C CA  . PHE A 1 184 ? 140.995 152.593 171.043 1.00 53.06  ? 209 PHE A CA  1 
ATOM   1313 C C   . PHE A 1 184 ? 141.123 151.376 170.137 1.00 53.06  ? 209 PHE A C   1 
ATOM   1314 O O   . PHE A 1 184 ? 140.426 151.275 169.121 1.00 53.06  ? 209 PHE A O   1 
ATOM   1315 C CB  . PHE A 1 184 ? 142.119 153.588 170.754 1.00 53.06  ? 209 PHE A CB  1 
ATOM   1316 C CG  . PHE A 1 184 ? 141.729 155.020 170.964 1.00 53.06  ? 209 PHE A CG  1 
ATOM   1317 C CD1 . PHE A 1 184 ? 140.398 155.382 171.058 1.00 53.06  ? 209 PHE A CD1 1 
ATOM   1318 C CD2 . PHE A 1 184 ? 142.695 156.005 171.056 1.00 53.06  ? 209 PHE A CD2 1 
ATOM   1319 C CE1 . PHE A 1 184 ? 140.037 156.699 171.247 1.00 53.06  ? 209 PHE A CE1 1 
ATOM   1320 C CE2 . PHE A 1 184 ? 142.341 157.324 171.245 1.00 53.06  ? 209 PHE A CE2 1 
ATOM   1321 C CZ  . PHE A 1 184 ? 141.010 157.671 171.341 1.00 53.06  ? 209 PHE A CZ  1 
ATOM   1322 N N   . SER A 1 185 ? 142.010 150.441 170.484 1.00 57.69  ? 210 SER A N   1 
ATOM   1323 C CA  . SER A 1 185 ? 142.171 149.245 169.667 1.00 57.69  ? 210 SER A CA  1 
ATOM   1324 C C   . SER A 1 185 ? 140.951 148.336 169.722 1.00 57.69  ? 210 SER A C   1 
ATOM   1325 O O   . SER A 1 185 ? 140.806 147.465 168.858 1.00 57.69  ? 210 SER A O   1 
ATOM   1326 C CB  . SER A 1 185 ? 143.415 148.471 170.103 1.00 57.69  ? 210 SER A CB  1 
ATOM   1327 O OG  . SER A 1 185 ? 143.509 147.235 169.418 1.00 57.69  ? 210 SER A OG  1 
ATOM   1328 N N   . LYS A 1 186 ? 140.075 148.515 170.714 1.00 62.23  ? 211 LYS A N   1 
ATOM   1329 C CA  . LYS A 1 186 ? 138.893 147.663 170.817 1.00 62.23  ? 211 LYS A CA  1 
ATOM   1330 C C   . LYS A 1 186 ? 137.945 147.878 169.641 1.00 62.23  ? 211 LYS A C   1 
ATOM   1331 O O   . LYS A 1 186 ? 137.633 146.937 168.903 1.00 62.23  ? 211 LYS A O   1 
ATOM   1332 C CB  . LYS A 1 186 ? 138.177 147.920 172.143 1.00 62.23  ? 211 LYS A CB  1 
ATOM   1333 C CG  . LYS A 1 186 ? 137.015 146.978 172.414 1.00 62.23  ? 211 LYS A CG  1 
ATOM   1334 C CD  . LYS A 1 186 ? 137.469 145.527 172.439 1.00 62.23  ? 211 LYS A CD  1 
ATOM   1335 C CE  . LYS A 1 186 ? 138.488 145.283 173.541 1.00 62.23  ? 211 LYS A CE  1 
ATOM   1336 N NZ  . LYS A 1 186 ? 137.976 145.699 174.876 1.00 62.23  ? 211 LYS A NZ  1 
ATOM   1337 N N   . TRP A 1 187 ? 137.475 149.110 169.449 1.00 64.20  ? 212 TRP A N   1 
ATOM   1338 C CA  . TRP A 1 187 ? 136.507 149.419 168.395 1.00 64.20  ? 212 TRP A CA  1 
ATOM   1339 C C   . TRP A 1 187 ? 137.271 149.678 167.102 1.00 64.20  ? 212 TRP A C   1 
ATOM   1340 O O   . TRP A 1 187 ? 137.907 150.721 166.936 1.00 64.20  ? 212 TRP A O   1 
ATOM   1341 C CB  . TRP A 1 187 ? 135.622 150.600 168.788 1.00 64.20  ? 212 TRP A CB  1 
ATOM   1342 C CG  . TRP A 1 187 ? 136.350 151.844 169.230 1.00 64.20  ? 212 TRP A CG  1 
ATOM   1343 C CD1 . TRP A 1 187 ? 137.224 151.957 170.268 1.00 64.20  ? 212 TRP A CD1 1 
ATOM   1344 C CD2 . TRP A 1 187 ? 136.218 153.161 168.677 1.00 64.20  ? 212 TRP A CD2 1 
ATOM   1345 N NE1 . TRP A 1 187 ? 137.670 153.250 170.379 1.00 64.20  ? 212 TRP A NE1 1 
ATOM   1346 C CE2 . TRP A 1 187 ? 137.064 154.011 169.416 1.00 64.20  ? 212 TRP A CE2 1 
ATOM   1347 C CE3 . TRP A 1 187 ? 135.477 153.700 167.622 1.00 64.20  ? 212 TRP A CE3 1 
ATOM   1348 C CZ2 . TRP A 1 187 ? 137.189 155.369 169.135 1.00 64.20  ? 212 TRP A CZ2 1 
ATOM   1349 C CZ3 . TRP A 1 187 ? 135.603 155.050 167.345 1.00 64.20  ? 212 TRP A CZ3 1 
ATOM   1350 C CH2 . TRP A 1 187 ? 136.452 155.868 168.098 1.00 64.20  ? 212 TRP A CH2 1 
ATOM   1351 N N   . GLY A 1 188 ? 137.203 148.719 166.181 1.00 72.97  ? 213 GLY A N   1 
ATOM   1352 C CA  . GLY A 1 188 ? 137.974 148.766 164.955 1.00 72.97  ? 213 GLY A CA  1 
ATOM   1353 C C   . GLY A 1 188 ? 137.478 149.757 163.922 1.00 72.97  ? 213 GLY A C   1 
ATOM   1354 O O   . GLY A 1 188 ? 138.195 150.698 163.571 1.00 72.97  ? 213 GLY A O   1 
ATOM   1355 N N   . GLU A 1 189 ? 136.263 149.556 163.418 1.00 77.75  ? 214 GLU A N   1 
ATOM   1356 C CA  . GLU A 1 189 ? 135.732 150.407 162.364 1.00 77.75  ? 214 GLU A CA  1 
ATOM   1357 C C   . GLU A 1 189 ? 134.221 150.510 162.504 1.00 77.75  ? 214 GLU A C   1 
ATOM   1358 O O   . GLU A 1 189 ? 133.544 149.513 162.768 1.00 77.75  ? 214 GLU A O   1 
ATOM   1359 C CB  . GLU A 1 189 ? 136.099 149.869 160.977 1.00 77.75  ? 214 GLU A CB  1 
ATOM   1360 C CG  . GLU A 1 189 ? 135.864 150.853 159.845 1.00 77.75  ? 214 GLU A CG  1 
ATOM   1361 C CD  . GLU A 1 189 ? 136.346 150.325 158.510 1.00 77.75  ? 214 GLU A CD  1 
ATOM   1362 O OE1 . GLU A 1 189 ? 136.655 149.118 158.424 1.00 77.75  ? 214 GLU A OE1 1 
ATOM   1363 O OE2 . GLU A 1 189 ? 136.418 151.116 157.547 1.00 77.75  ? 214 GLU A OE2 1 
ATOM   1364 N N   . SER A 1 190 ? 133.704 151.722 162.321 1.00 83.85  ? 215 SER A N   1 
ATOM   1365 C CA  . SER A 1 190 ? 132.277 151.995 162.415 1.00 83.85  ? 215 SER A CA  1 
ATOM   1366 C C   . SER A 1 190 ? 131.979 153.251 161.609 1.00 83.85  ? 215 SER A C   1 
ATOM   1367 O O   . SER A 1 190 ? 132.870 154.082 161.398 1.00 83.85  ? 215 SER A O   1 
ATOM   1368 C CB  . SER A 1 190 ? 131.836 152.176 163.879 1.00 83.85  ? 215 SER A CB  1 
ATOM   1369 O OG  . SER A 1 190 ? 132.376 151.169 164.718 1.00 83.85  ? 215 SER A OG  1 
ATOM   1370 N N   . PRO A 1 191 ? 130.735 153.419 161.136 1.00 82.65  ? 216 PRO A N   1 
ATOM   1371 C CA  . PRO A 1 191 ? 130.374 154.646 160.418 1.00 82.65  ? 216 PRO A CA  1 
ATOM   1372 C C   . PRO A 1 191 ? 130.333 155.867 161.334 1.00 82.65  ? 216 PRO A C   1 
ATOM   1373 O O   . PRO A 1 191 ? 130.401 156.991 160.839 1.00 82.65  ? 216 PRO A O   1 
ATOM   1374 C CB  . PRO A 1 191 ? 128.981 154.332 159.865 1.00 82.65  ? 216 PRO A CB  1 
ATOM   1375 C CG  . PRO A 1 191 ? 128.442 153.284 160.778 1.00 82.65  ? 216 PRO A CG  1 
ATOM   1376 C CD  . PRO A 1 191 ? 129.625 152.451 161.167 1.00 82.65  ? 216 PRO A CD  1 
ATOM   1377 N N   . PRO B 2 103 ? 155.677 193.709 139.448 1.00 107.42 ? 125 PRO B N   1 
ATOM   1378 C CA  . PRO B 2 103 ? 154.868 192.953 140.408 1.00 107.42 ? 125 PRO B CA  1 
ATOM   1379 C C   . PRO B 2 103 ? 155.115 191.450 140.328 1.00 107.42 ? 125 PRO B C   1 
ATOM   1380 O O   . PRO B 2 103 ? 155.005 190.871 139.248 1.00 107.42 ? 125 PRO B O   1 
ATOM   1381 C CB  . PRO B 2 103 ? 153.433 193.291 139.999 1.00 107.42 ? 125 PRO B CB  1 
ATOM   1382 C CG  . PRO B 2 103 ? 153.527 193.635 138.554 1.00 107.42 ? 125 PRO B CG  1 
ATOM   1383 C CD  . PRO B 2 103 ? 154.858 194.304 138.379 1.00 107.42 ? 125 PRO B CD  1 
ATOM   1384 N N   . PRO B 2 104 ? 155.448 190.831 141.453 1.00 111.90 ? 126 PRO B N   1 
ATOM   1385 C CA  . PRO B 2 104 ? 155.691 189.386 141.479 1.00 111.90 ? 126 PRO B CA  1 
ATOM   1386 C C   . PRO B 2 104 ? 154.377 188.614 141.400 1.00 111.90 ? 126 PRO B C   1 
ATOM   1387 O O   . PRO B 2 104 ? 153.288 189.170 141.526 1.00 111.90 ? 126 PRO B O   1 
ATOM   1388 C CB  . PRO B 2 104 ? 156.388 189.178 142.824 1.00 111.90 ? 126 PRO B CB  1 
ATOM   1389 C CG  . PRO B 2 104 ? 155.859 190.273 143.682 1.00 111.90 ? 126 PRO B CG  1 
ATOM   1390 C CD  . PRO B 2 104 ? 155.664 191.454 142.770 1.00 111.90 ? 126 PRO B CD  1 
ATOM   1391 N N   . GLU B 2 105 ? 154.502 187.305 141.193 1.00 110.20 ? 127 GLU B N   1 
ATOM   1392 C CA  . GLU B 2 105 ? 153.358 186.416 141.059 1.00 110.20 ? 127 GLU B CA  1 
ATOM   1393 C C   . GLU B 2 105 ? 153.468 185.292 142.082 1.00 110.20 ? 127 GLU B C   1 
ATOM   1394 O O   . GLU B 2 105 ? 154.508 185.098 142.718 1.00 110.20 ? 127 GLU B O   1 
ATOM   1395 C CB  . GLU B 2 105 ? 153.253 185.863 139.631 1.00 110.20 ? 127 GLU B CB  1 
ATOM   1396 C CG  . GLU B 2 105 ? 154.541 185.270 139.087 1.00 110.20 ? 127 GLU B CG  1 
ATOM   1397 C CD  . GLU B 2 105 ? 154.666 183.790 139.373 1.00 110.20 ? 127 GLU B CD  1 
ATOM   1398 O OE1 . GLU B 2 105 ? 155.805 183.308 139.542 1.00 110.20 ? 127 GLU B OE1 1 
ATOM   1399 O OE2 . GLU B 2 105 ? 153.623 183.106 139.411 1.00 110.20 ? 127 GLU B OE2 1 
ATOM   1400 N N   . LYS B 2 106 ? 152.375 184.548 142.237 1.00 96.63  ? 128 LYS B N   1 
ATOM   1401 C CA  . LYS B 2 106 ? 152.291 183.561 143.305 1.00 96.63  ? 128 LYS B CA  1 
ATOM   1402 C C   . LYS B 2 106 ? 153.242 182.396 143.036 1.00 96.63  ? 128 LYS B C   1 
ATOM   1403 O O   . LYS B 2 106 ? 153.435 182.001 141.882 1.00 96.63  ? 128 LYS B O   1 
ATOM   1404 C CB  . LYS B 2 106 ? 150.859 183.047 143.451 1.00 96.63  ? 128 LYS B CB  1 
ATOM   1405 C CG  . LYS B 2 106 ? 150.365 182.208 142.287 1.00 96.63  ? 128 LYS B CG  1 
ATOM   1406 C CD  . LYS B 2 106 ? 149.080 181.483 142.638 1.00 96.63  ? 128 LYS B CD  1 
ATOM   1407 C CE  . LYS B 2 106 ? 148.675 180.518 141.538 1.00 96.63  ? 128 LYS B CE  1 
ATOM   1408 N NZ  . LYS B 2 106 ? 147.433 179.773 141.881 1.00 96.63  ? 128 LYS B NZ  1 
ATOM   1409 N N   . PRO B 2 107 ? 153.858 181.834 144.073 1.00 94.09  ? 129 PRO B N   1 
ATOM   1410 C CA  . PRO B 2 107 ? 154.751 180.689 143.864 1.00 94.09  ? 129 PRO B CA  1 
ATOM   1411 C C   . PRO B 2 107 ? 154.000 179.368 143.827 1.00 94.09  ? 129 PRO B C   1 
ATOM   1412 O O   . PRO B 2 107 ? 152.783 179.328 144.039 1.00 94.09  ? 129 PRO B O   1 
ATOM   1413 C CB  . PRO B 2 107 ? 155.699 180.767 145.065 1.00 94.09  ? 129 PRO B CB  1 
ATOM   1414 C CG  . PRO B 2 107 ? 154.873 181.386 146.139 1.00 94.09  ? 129 PRO B CG  1 
ATOM   1415 C CD  . PRO B 2 107 ? 153.870 182.300 145.471 1.00 94.09  ? 129 PRO B CD  1 
ATOM   1416 N N   . LYS B 2 108 ? 154.718 178.281 143.564 1.00 93.06  ? 130 LYS B N   1 
ATOM   1417 C CA  . LYS B 2 108 ? 154.121 176.957 143.440 1.00 93.06  ? 130 LYS B CA  1 
ATOM   1418 C C   . LYS B 2 108 ? 155.229 175.940 143.729 1.00 93.06  ? 130 LYS B C   1 
ATOM   1419 O O   . LYS B 2 108 ? 156.280 176.301 144.271 1.00 93.06  ? 130 LYS B O   1 
ATOM   1420 C CB  . LYS B 2 108 ? 153.461 176.809 142.056 1.00 93.06  ? 130 LYS B CB  1 
ATOM   1421 C CG  . LYS B 2 108 ? 152.583 175.576 141.864 1.00 93.06  ? 130 LYS B CG  1 
ATOM   1422 C CD  . LYS B 2 108 ? 151.418 175.571 142.836 1.00 93.06  ? 130 LYS B CD  1 
ATOM   1423 C CE  . LYS B 2 108 ? 150.462 176.716 142.553 1.00 93.06  ? 130 LYS B CE  1 
ATOM   1424 N NZ  . LYS B 2 108 ? 149.759 176.532 141.254 1.00 93.06  ? 130 LYS B NZ  1 
ATOM   1425 N N   . ASN B 2 109 ? 154.988 174.670 143.395 1.00 96.56  ? 131 ASN B N   1 
ATOM   1426 C CA  . ASN B 2 109 ? 155.968 173.601 143.583 1.00 96.56  ? 131 ASN B CA  1 
ATOM   1427 C C   . ASN B 2 109 ? 156.345 173.461 145.057 1.00 96.56  ? 131 ASN B C   1 
ATOM   1428 O O   . ASN B 2 109 ? 157.520 173.369 145.420 1.00 96.56  ? 131 ASN B O   1 
ATOM   1429 C CB  . ASN B 2 109 ? 157.209 173.833 142.716 1.00 96.56  ? 131 ASN B CB  1 
ATOM   1430 C CG  . ASN B 2 109 ? 157.984 172.560 142.451 1.00 96.56  ? 131 ASN B CG  1 
ATOM   1431 O OD1 . ASN B 2 109 ? 158.931 172.235 143.166 1.00 96.56  ? 131 ASN B OD1 1 
ATOM   1432 N ND2 . ASN B 2 109 ? 157.586 171.833 141.416 1.00 96.56  ? 131 ASN B ND2 1 
ATOM   1433 N N   . LEU B 2 110 ? 155.329 173.450 145.913 1.00 85.89  ? 132 LEU B N   1 
ATOM   1434 C CA  . LEU B 2 110 ? 155.532 173.344 147.350 1.00 85.89  ? 132 LEU B CA  1 
ATOM   1435 C C   . LEU B 2 110 ? 155.664 171.877 147.744 1.00 85.89  ? 132 LEU B C   1 
ATOM   1436 O O   . LEU B 2 110 ? 154.893 171.029 147.283 1.00 85.89  ? 132 LEU B O   1 
ATOM   1437 C CB  . LEU B 2 110 ? 154.384 174.013 148.114 1.00 85.89  ? 132 LEU B CB  1 
ATOM   1438 C CG  . LEU B 2 110 ? 153.002 173.355 148.207 1.00 85.89  ? 132 LEU B CG  1 
ATOM   1439 C CD1 . LEU B 2 110 ? 152.197 173.991 149.330 1.00 85.89  ? 132 LEU B CD1 1 
ATOM   1440 C CD2 . LEU B 2 110 ? 152.243 173.447 146.891 1.00 85.89  ? 132 LEU B CD2 1 
ATOM   1441 N N   . SER B 2 111 ? 156.657 171.584 148.579 1.00 81.27  ? 133 SER B N   1 
ATOM   1442 C CA  . SER B 2 111 ? 156.891 170.233 149.064 1.00 81.27  ? 133 SER B CA  1 
ATOM   1443 C C   . SER B 2 111 ? 157.687 170.313 150.356 1.00 81.27  ? 133 SER B C   1 
ATOM   1444 O O   . SER B 2 111 ? 158.510 171.214 150.538 1.00 81.27  ? 133 SER B O   1 
ATOM   1445 C CB  . SER B 2 111 ? 157.634 169.381 148.029 1.00 81.27  ? 133 SER B CB  1 
ATOM   1446 O OG  . SER B 2 111 ? 158.985 169.790 147.912 1.00 81.27  ? 133 SER B OG  1 
ATOM   1447 N N   . CYS B 2 112 ? 157.440 169.359 151.250 1.00 70.62  ? 134 CYS B N   1 
ATOM   1448 C CA  . CYS B 2 112 ? 158.080 169.352 152.556 1.00 70.62  ? 134 CYS B CA  1 
ATOM   1449 C C   . CYS B 2 112 ? 158.640 167.969 152.846 1.00 70.62  ? 134 CYS B C   1 
ATOM   1450 O O   . CYS B 2 112 ? 158.026 166.956 152.501 1.00 70.62  ? 134 CYS B O   1 
ATOM   1451 C CB  . CYS B 2 112 ? 157.098 169.765 153.659 1.00 70.62  ? 134 CYS B CB  1 
ATOM   1452 S SG  . CYS B 2 112 ? 156.307 171.368 153.382 1.00 70.62  ? 134 CYS B SG  1 
ATOM   1453 N N   . ILE B 2 113 ? 159.806 167.937 153.486 1.00 64.10  ? 135 ILE B N   1 
ATOM   1454 C CA  . ILE B 2 113 ? 160.489 166.696 153.830 1.00 64.10  ? 135 ILE B CA  1 
ATOM   1455 C C   . ILE B 2 113 ? 160.876 166.750 155.301 1.00 64.10  ? 135 ILE B C   1 
ATOM   1456 O O   . ILE B 2 113 ? 161.265 167.805 155.814 1.00 64.10  ? 135 ILE B O   1 
ATOM   1457 C CB  . ILE B 2 113 ? 161.724 166.464 152.932 1.00 64.10  ? 135 ILE B CB  1 
ATOM   1458 C CG1 . ILE B 2 113 ? 162.408 165.138 153.274 1.00 64.10  ? 135 ILE B CG1 1 
ATOM   1459 C CG2 . ILE B 2 113 ? 162.701 167.625 153.038 1.00 64.10  ? 135 ILE B CG2 1 
ATOM   1460 C CD1 . ILE B 2 113 ? 163.458 164.717 152.269 1.00 64.10  ? 135 ILE B CD1 1 
ATOM   1461 N N   . VAL B 2 114 ? 160.753 165.616 155.985 1.00 61.82  ? 136 VAL B N   1 
ATOM   1462 C CA  . VAL B 2 114 ? 161.065 165.506 157.405 1.00 61.82  ? 136 VAL B CA  1 
ATOM   1463 C C   . VAL B 2 114 ? 162.196 164.502 157.563 1.00 61.82  ? 136 VAL B C   1 
ATOM   1464 O O   . VAL B 2 114 ? 162.097 163.367 157.080 1.00 61.82  ? 136 VAL B O   1 
ATOM   1465 C CB  . VAL B 2 114 ? 159.841 165.079 158.231 1.00 61.82  ? 136 VAL B CB  1 
ATOM   1466 C CG1 . VAL B 2 114 ? 160.175 165.080 159.713 1.00 61.82  ? 136 VAL B CG1 1 
ATOM   1467 C CG2 . VAL B 2 114 ? 158.659 165.990 157.943 1.00 61.82  ? 136 VAL B CG2 1 
ATOM   1468 N N   . ASN B 2 115 ? 163.267 164.916 158.232 1.00 74.23  ? 137 ASN B N   1 
ATOM   1469 C CA  . ASN B 2 115 ? 164.366 164.010 158.516 1.00 74.23  ? 137 ASN B CA  1 
ATOM   1470 C C   . ASN B 2 115 ? 164.103 163.248 159.813 1.00 74.23  ? 137 ASN B C   1 
ATOM   1471 O O   . ASN B 2 115 ? 163.078 163.426 160.476 1.00 74.23  ? 137 ASN B O   1 
ATOM   1472 C CB  . ASN B 2 115 ? 165.686 164.774 158.600 1.00 74.23  ? 137 ASN B CB  1 
ATOM   1473 C CG  . ASN B 2 115 ? 166.082 165.395 157.277 1.00 74.23  ? 137 ASN B CG  1 
ATOM   1474 O OD1 . ASN B 2 115 ? 165.232 165.688 156.438 1.00 74.23  ? 137 ASN B OD1 1 
ATOM   1475 N ND2 . ASN B 2 115 ? 167.380 165.597 157.084 1.00 74.23  ? 137 ASN B ND2 1 
ATOM   1476 N N   . GLU B 2 116 ? 165.048 162.385 160.174 1.00 75.26  ? 138 GLU B N   1 
ATOM   1477 C CA  . GLU B 2 116 ? 164.903 161.574 161.376 1.00 75.26  ? 138 GLU B CA  1 
ATOM   1478 C C   . GLU B 2 116 ? 165.111 162.434 162.617 1.00 75.26  ? 138 GLU B C   1 
ATOM   1479 O O   . GLU B 2 116 ? 166.242 162.818 162.934 1.00 75.26  ? 138 GLU B O   1 
ATOM   1480 C CB  . GLU B 2 116 ? 165.894 160.414 161.356 1.00 75.26  ? 138 GLU B CB  1 
ATOM   1481 C CG  . GLU B 2 116 ? 165.734 159.453 162.522 1.00 75.26  ? 138 GLU B CG  1 
ATOM   1482 C CD  . GLU B 2 116 ? 166.704 158.291 162.463 1.00 75.26  ? 138 GLU B CD  1 
ATOM   1483 O OE1 . GLU B 2 116 ? 167.641 158.253 163.287 1.00 75.26  ? 138 GLU B OE1 1 
ATOM   1484 O OE2 . GLU B 2 116 ? 166.531 157.414 161.591 1.00 75.26  ? 138 GLU B OE2 1 
ATOM   1485 N N   . GLY B 2 117 ? 164.022 162.732 163.318 1.00 79.92  ? 139 GLY B N   1 
ATOM   1486 C CA  . GLY B 2 117 ? 164.112 163.476 164.566 1.00 79.92  ? 139 GLY B CA  1 
ATOM   1487 C C   . GLY B 2 117 ? 164.598 164.900 164.414 1.00 79.92  ? 139 GLY B C   1 
ATOM   1488 O O   . GLY B 2 117 ? 165.412 165.365 165.222 1.00 79.92  ? 139 GLY B O   1 
ATOM   1489 N N   . LYS B 2 118 ? 164.118 165.608 163.393 1.00 78.03  ? 140 LYS B N   1 
ATOM   1490 C CA  . LYS B 2 118 ? 164.485 166.998 163.166 1.00 78.03  ? 140 LYS B CA  1 
ATOM   1491 C C   . LYS B 2 118 ? 163.239 167.776 162.768 1.00 78.03  ? 140 LYS B C   1 
ATOM   1492 O O   . LYS B 2 118 ? 162.128 167.237 162.732 1.00 78.03  ? 140 LYS B O   1 
ATOM   1493 C CB  . LYS B 2 118 ? 165.579 167.120 162.098 1.00 78.03  ? 140 LYS B CB  1 
ATOM   1494 C CG  . LYS B 2 118 ? 166.922 166.542 162.510 1.00 78.03  ? 140 LYS B CG  1 
ATOM   1495 C CD  . LYS B 2 118 ? 167.997 166.864 161.488 1.00 78.03  ? 140 LYS B CD  1 
ATOM   1496 C CE  . LYS B 2 118 ? 169.309 166.183 161.838 1.00 78.03  ? 140 LYS B CE  1 
ATOM   1497 N NZ  . LYS B 2 118 ? 170.393 166.551 160.887 1.00 78.03  ? 140 LYS B NZ  1 
ATOM   1498 N N   . LYS B 2 119 ? 163.428 169.057 162.469 1.00 69.40  ? 141 LYS B N   1 
ATOM   1499 C CA  . LYS B 2 119 ? 162.324 169.908 162.059 1.00 69.40  ? 141 LYS B CA  1 
ATOM   1500 C C   . LYS B 2 119 ? 162.046 169.746 160.568 1.00 69.40  ? 141 LYS B C   1 
ATOM   1501 O O   . LYS B 2 119 ? 162.915 169.361 159.782 1.00 69.40  ? 141 LYS B O   1 
ATOM   1502 C CB  . LYS B 2 119 ? 162.621 171.371 162.385 1.00 69.40  ? 141 LYS B CB  1 
ATOM   1503 C CG  . LYS B 2 119 ? 162.489 171.718 163.858 1.00 69.40  ? 141 LYS B CG  1 
ATOM   1504 C CD  . LYS B 2 119 ? 163.835 171.696 164.560 1.00 69.40  ? 141 LYS B CD  1 
ATOM   1505 C CE  . LYS B 2 119 ? 163.675 171.879 166.059 1.00 69.40  ? 141 LYS B CE  1 
ATOM   1506 N NZ  . LYS B 2 119 ? 164.981 172.119 166.731 1.00 69.40  ? 141 LYS B NZ  1 
ATOM   1507 N N   . MET B 2 120 ? 160.811 170.054 160.183 1.00 64.83  ? 142 MET B N   1 
ATOM   1508 C CA  . MET B 2 120 ? 160.363 169.889 158.808 1.00 64.83  ? 142 MET B CA  1 
ATOM   1509 C C   . MET B 2 120 ? 160.680 171.138 157.997 1.00 64.83  ? 142 MET B C   1 
ATOM   1510 O O   . MET B 2 120 ? 160.281 172.246 158.369 1.00 64.83  ? 142 MET B O   1 
ATOM   1511 C CB  . MET B 2 120 ? 158.863 169.601 158.767 1.00 64.83  ? 142 MET B CB  1 
ATOM   1512 C CG  . MET B 2 120 ? 158.253 169.690 157.383 1.00 64.83  ? 142 MET B CG  1 
ATOM   1513 S SD  . MET B 2 120 ? 156.507 169.251 157.379 1.00 64.83  ? 142 MET B SD  1 
ATOM   1514 C CE  . MET B 2 120 ? 155.873 170.386 158.609 1.00 64.83  ? 142 MET B CE  1 
ATOM   1515 N N   . ARG B 2 121 ? 161.394 170.956 156.891 1.00 73.37  ? 143 ARG B N   1 
ATOM   1516 C CA  . ARG B 2 121 ? 161.684 172.036 155.961 1.00 73.37  ? 143 ARG B CA  1 
ATOM   1517 C C   . ARG B 2 121 ? 160.766 171.939 154.750 1.00 73.37  ? 143 ARG B C   1 
ATOM   1518 O O   . ARG B 2 121 ? 160.271 170.863 154.408 1.00 73.37  ? 143 ARG B O   1 
ATOM   1519 C CB  . ARG B 2 121 ? 163.147 172.001 155.511 1.00 73.37  ? 143 ARG B CB  1 
ATOM   1520 C CG  . ARG B 2 121 ? 163.464 170.902 154.513 1.00 73.37  ? 143 ARG B CG  1 
ATOM   1521 C CD  . ARG B 2 121 ? 164.839 171.090 153.892 1.00 73.37  ? 143 ARG B CD  1 
ATOM   1522 N NE  . ARG B 2 121 ? 165.912 170.709 154.805 1.00 73.37  ? 143 ARG B NE  1 
ATOM   1523 C CZ  . ARG B 2 121 ? 166.653 171.574 155.489 1.00 73.37  ? 143 ARG B CZ  1 
ATOM   1524 N NH1 . ARG B 2 121 ? 166.439 172.877 155.364 1.00 73.37  ? 143 ARG B NH1 1 
ATOM   1525 N NH2 . ARG B 2 121 ? 167.609 171.137 156.297 1.00 73.37  ? 143 ARG B NH2 1 
ATOM   1526 N N   . CYS B 2 122 ? 160.537 173.079 154.105 1.00 75.64  ? 144 CYS B N   1 
ATOM   1527 C CA  . CYS B 2 122 ? 159.687 173.148 152.927 1.00 75.64  ? 144 CYS B CA  1 
ATOM   1528 C C   . CYS B 2 122 ? 160.335 174.045 151.883 1.00 75.64  ? 144 CYS B C   1 
ATOM   1529 O O   . CYS B 2 122 ? 161.083 174.969 152.213 1.00 75.64  ? 144 CYS B O   1 
ATOM   1530 C CB  . CYS B 2 122 ? 158.287 173.668 153.274 1.00 75.64  ? 144 CYS B CB  1 
ATOM   1531 S SG  . CYS B 2 122 ? 157.403 172.667 154.493 1.00 75.64  ? 144 CYS B SG  1 
ATOM   1532 N N   . GLU B 2 123 ? 160.042 173.761 150.616 1.00 81.47  ? 145 GLU B N   1 
ATOM   1533 C CA  . GLU B 2 123 ? 160.611 174.490 149.493 1.00 81.47  ? 145 GLU B CA  1 
ATOM   1534 C C   . GLU B 2 123 ? 159.508 174.874 148.516 1.00 81.47  ? 145 GLU B C   1 
ATOM   1535 O O   . GLU B 2 123 ? 158.385 174.366 148.575 1.00 81.47  ? 145 GLU B O   1 
ATOM   1536 C CB  . GLU B 2 123 ? 161.690 173.665 148.776 1.00 81.47  ? 145 GLU B CB  1 
ATOM   1537 C CG  . GLU B 2 123 ? 162.663 172.961 149.706 1.00 81.47  ? 145 GLU B CG  1 
ATOM   1538 C CD  . GLU B 2 123 ? 163.622 172.053 148.966 1.00 81.47  ? 145 GLU B CD  1 
ATOM   1539 O OE1 . GLU B 2 123 ? 164.318 172.540 148.051 1.00 81.47  ? 145 GLU B OE1 1 
ATOM   1540 O OE2 . GLU B 2 123 ? 163.679 170.850 149.298 1.00 81.47  ? 145 GLU B OE2 1 
ATOM   1541 N N   . TRP B 2 124 ? 159.846 175.786 147.608 1.00 88.18  ? 146 TRP B N   1 
ATOM   1542 C CA  . TRP B 2 124 ? 158.927 176.245 146.573 1.00 88.18  ? 146 TRP B CA  1 
ATOM   1543 C C   . TRP B 2 124 ? 159.753 176.758 145.398 1.00 88.18  ? 146 TRP B C   1 
ATOM   1544 O O   . TRP B 2 124 ? 160.969 176.556 145.337 1.00 88.18  ? 146 TRP B O   1 
ATOM   1545 C CB  . TRP B 2 124 ? 157.975 177.313 147.126 1.00 88.18  ? 146 TRP B CB  1 
ATOM   1546 C CG  . TRP B 2 124 ? 158.675 178.452 147.800 1.00 88.18  ? 146 TRP B CG  1 
ATOM   1547 C CD1 . TRP B 2 124 ? 159.304 179.500 147.196 1.00 88.18  ? 146 TRP B CD1 1 
ATOM   1548 C CD2 . TRP B 2 124 ? 158.815 178.659 149.210 1.00 88.18  ? 146 TRP B CD2 1 
ATOM   1549 N NE1 . TRP B 2 124 ? 159.829 180.345 148.142 1.00 88.18  ? 146 TRP B NE1 1 
ATOM   1550 C CE2 . TRP B 2 124 ? 159.542 179.851 149.387 1.00 88.18  ? 146 TRP B CE2 1 
ATOM   1551 C CE3 . TRP B 2 124 ? 158.397 177.950 150.341 1.00 88.18  ? 146 TRP B CE3 1 
ATOM   1552 C CZ2 . TRP B 2 124 ? 159.860 180.351 150.647 1.00 88.18  ? 146 TRP B CZ2 1 
ATOM   1553 C CZ3 . TRP B 2 124 ? 158.714 178.449 151.590 1.00 88.18  ? 146 TRP B CZ3 1 
ATOM   1554 C CH2 . TRP B 2 124 ? 159.438 179.637 151.733 1.00 88.18  ? 146 TRP B CH2 1 
ATOM   1555 N N   . ASP B 2 125 ? 159.088 177.425 144.459 1.00 94.01  ? 147 ASP B N   1 
ATOM   1556 C CA  . ASP B 2 125 ? 159.743 177.986 143.288 1.00 94.01  ? 147 ASP B CA  1 
ATOM   1557 C C   . ASP B 2 125 ? 159.834 179.502 143.409 1.00 94.01  ? 147 ASP B C   1 
ATOM   1558 O O   . ASP B 2 125 ? 159.070 180.132 144.146 1.00 94.01  ? 147 ASP B O   1 
ATOM   1559 C CB  . ASP B 2 125 ? 159.004 177.603 141.999 1.00 94.01  ? 147 ASP B CB  1 
ATOM   1560 C CG  . ASP B 2 125 ? 157.523 177.943 142.042 1.00 94.01  ? 147 ASP B CG  1 
ATOM   1561 O OD1 . ASP B 2 125 ? 157.075 178.585 143.014 1.00 94.01  ? 147 ASP B OD1 1 
ATOM   1562 O OD2 . ASP B 2 125 ? 156.801 177.562 141.097 1.00 94.01  ? 147 ASP B OD2 1 
ATOM   1563 N N   . GLY B 2 126 ? 160.784 180.082 142.681 1.00 101.59 ? 148 GLY B N   1 
ATOM   1564 C CA  . GLY B 2 126 ? 160.983 181.516 142.712 1.00 101.59 ? 148 GLY B CA  1 
ATOM   1565 C C   . GLY B 2 126 ? 160.002 182.278 141.847 1.00 101.59 ? 148 GLY B C   1 
ATOM   1566 O O   . GLY B 2 126 ? 159.420 183.275 142.284 1.00 101.59 ? 148 GLY B O   1 
ATOM   1567 N N   . GLY B 2 127 ? 159.808 181.817 140.618 1.00 107.68 ? 149 GLY B N   1 
ATOM   1568 C CA  . GLY B 2 127 ? 158.929 182.495 139.688 1.00 107.68 ? 149 GLY B CA  1 
ATOM   1569 C C   . GLY B 2 127 ? 159.668 183.508 138.836 1.00 107.68 ? 149 GLY B C   1 
ATOM   1570 O O   . GLY B 2 127 ? 160.898 183.502 138.721 1.00 107.68 ? 149 GLY B O   1 
ATOM   1571 N N   . ARG B 2 128 ? 158.891 184.399 138.227 1.00 113.80 ? 150 ARG B N   1 
ATOM   1572 C CA  . ARG B 2 128 ? 159.468 185.428 137.378 1.00 113.80 ? 150 ARG B CA  1 
ATOM   1573 C C   . ARG B 2 128 ? 160.159 186.497 138.221 1.00 113.80 ? 150 ARG B C   1 
ATOM   1574 O O   . ARG B 2 128 ? 159.862 186.687 139.404 1.00 113.80 ? 150 ARG B O   1 
ATOM   1575 C CB  . ARG B 2 128 ? 158.394 186.065 136.496 1.00 113.80 ? 150 ARG B CB  1 
ATOM   1576 C CG  . ARG B 2 128 ? 157.392 186.924 137.250 1.00 113.80 ? 150 ARG B CG  1 
ATOM   1577 C CD  . ARG B 2 128 ? 156.290 187.417 136.327 1.00 113.80 ? 150 ARG B CD  1 
ATOM   1578 N NE  . ARG B 2 128 ? 155.401 188.365 136.991 1.00 113.80 ? 150 ARG B NE  1 
ATOM   1579 C CZ  . ARG B 2 128 ? 154.292 188.853 136.447 1.00 113.80 ? 150 ARG B CZ  1 
ATOM   1580 N NH1 . ARG B 2 128 ? 153.932 188.483 135.226 1.00 113.80 ? 150 ARG B NH1 1 
ATOM   1581 N NH2 . ARG B 2 128 ? 153.541 189.712 137.123 1.00 113.80 ? 150 ARG B NH2 1 
ATOM   1582 N N   . GLU B 2 129 ? 161.098 187.198 137.593 1.00 117.12 ? 151 GLU B N   1 
ATOM   1583 C CA  . GLU B 2 129 ? 161.862 188.252 138.245 1.00 117.12 ? 151 GLU B CA  1 
ATOM   1584 C C   . GLU B 2 129 ? 161.226 189.600 137.932 1.00 117.12 ? 151 GLU B C   1 
ATOM   1585 O O   . GLU B 2 129 ? 160.886 189.878 136.777 1.00 117.12 ? 151 GLU B O   1 
ATOM   1586 C CB  . GLU B 2 129 ? 163.320 188.230 137.785 1.00 117.12 ? 151 GLU B CB  1 
ATOM   1587 C CG  . GLU B 2 129 ? 164.311 188.714 138.830 1.00 117.12 ? 151 GLU B CG  1 
ATOM   1588 C CD  . GLU B 2 129 ? 164.521 190.213 138.785 1.00 117.12 ? 151 GLU B CD  1 
ATOM   1589 O OE1 . GLU B 2 129 ? 164.103 190.843 137.791 1.00 117.12 ? 151 GLU B OE1 1 
ATOM   1590 O OE2 . GLU B 2 129 ? 165.105 190.762 139.742 1.00 117.12 ? 151 GLU B OE2 1 
ATOM   1591 N N   . THR B 2 130 ? 161.066 190.433 138.962 1.00 119.01 ? 152 THR B N   1 
ATOM   1592 C CA  . THR B 2 130 ? 160.406 191.725 138.818 1.00 119.01 ? 152 THR B CA  1 
ATOM   1593 C C   . THR B 2 130 ? 161.259 192.888 139.311 1.00 119.01 ? 152 THR B C   1 
ATOM   1594 O O   . THR B 2 130 ? 160.744 194.005 139.441 1.00 119.01 ? 152 THR B O   1 
ATOM   1595 C CB  . THR B 2 130 ? 159.065 191.722 139.557 1.00 119.01 ? 152 THR B CB  1 
ATOM   1596 O OG1 . THR B 2 130 ? 158.489 193.034 139.508 1.00 119.01 ? 152 THR B OG1 1 
ATOM   1597 C CG2 . THR B 2 130 ? 159.258 191.312 141.009 1.00 119.01 ? 152 THR B CG2 1 
ATOM   1598 N N   . HIS B 2 131 ? 162.540 192.657 139.596 1.00 119.02 ? 153 HIS B N   1 
ATOM   1599 C CA  . HIS B 2 131 ? 163.490 193.672 140.045 1.00 119.02 ? 153 HIS B CA  1 
ATOM   1600 C C   . HIS B 2 131 ? 163.086 194.332 141.358 1.00 119.02 ? 153 HIS B C   1 
ATOM   1601 O O   . HIS B 2 131 ? 163.679 195.347 141.742 1.00 119.02 ? 153 HIS B O   1 
ATOM   1602 C CB  . HIS B 2 131 ? 163.711 194.751 138.975 1.00 119.02 ? 153 HIS B CB  1 
ATOM   1603 C CG  . HIS B 2 131 ? 163.734 194.220 137.575 1.00 119.02 ? 153 HIS B CG  1 
ATOM   1604 N ND1 . HIS B 2 131 ? 164.843 193.612 137.028 1.00 119.02 ? 153 HIS B ND1 1 
ATOM   1605 C CD2 . HIS B 2 131 ? 162.784 194.207 136.611 1.00 119.02 ? 153 HIS B CD2 1 
ATOM   1606 C CE1 . HIS B 2 131 ? 164.575 193.247 135.787 1.00 119.02 ? 153 HIS B CE1 1 
ATOM   1607 N NE2 . HIS B 2 131 ? 163.332 193.597 135.509 1.00 119.02 ? 153 HIS B NE2 1 
ATOM   1608 N N   . LEU B 2 132 ? 162.098 193.786 142.061 1.00 115.97 ? 154 LEU B N   1 
ATOM   1609 C CA  . LEU B 2 132 ? 161.626 194.337 143.322 1.00 115.97 ? 154 LEU B CA  1 
ATOM   1610 C C   . LEU B 2 132 ? 161.884 193.340 144.441 1.00 115.97 ? 154 LEU B C   1 
ATOM   1611 O O   . LEU B 2 132 ? 161.703 192.131 144.262 1.00 115.97 ? 154 LEU B O   1 
ATOM   1612 C CB  . LEU B 2 132 ? 160.133 194.678 143.256 1.00 115.97 ? 154 LEU B CB  1 
ATOM   1613 C CG  . LEU B 2 132 ? 159.751 195.891 142.407 1.00 115.97 ? 154 LEU B CG  1 
ATOM   1614 C CD1 . LEU B 2 132 ? 158.242 196.011 142.289 1.00 115.97 ? 154 LEU B CD1 1 
ATOM   1615 C CD2 . LEU B 2 132 ? 160.345 197.160 142.994 1.00 115.97 ? 154 LEU B CD2 1 
ATOM   1616 N N   . GLU B 2 133 ? 162.312 193.851 145.592 1.00 111.81 ? 155 GLU B N   1 
ATOM   1617 C CA  . GLU B 2 133 ? 162.579 192.992 146.736 1.00 111.81 ? 155 GLU B CA  1 
ATOM   1618 C C   . GLU B 2 133 ? 161.290 192.344 147.225 1.00 111.81 ? 155 GLU B C   1 
ATOM   1619 O O   . GLU B 2 133 ? 160.233 192.979 147.271 1.00 111.81 ? 155 GLU B O   1 
ATOM   1620 C CB  . GLU B 2 133 ? 163.232 193.791 147.863 1.00 111.81 ? 155 GLU B CB  1 
ATOM   1621 C CG  . GLU B 2 133 ? 162.478 195.050 148.254 1.00 111.81 ? 155 GLU B CG  1 
ATOM   1622 C CD  . GLU B 2 133 ? 161.531 194.823 149.414 1.00 111.81 ? 155 GLU B CD  1 
ATOM   1623 O OE1 . GLU B 2 133 ? 161.690 193.805 150.120 1.00 111.81 ? 155 GLU B OE1 1 
ATOM   1624 O OE2 . GLU B 2 133 ? 160.627 195.659 149.620 1.00 111.81 ? 155 GLU B OE2 1 
ATOM   1625 N N   . THR B 2 134 ? 161.382 191.065 147.582 1.00 108.61 ? 156 THR B N   1 
ATOM   1626 C CA  . THR B 2 134 ? 160.236 190.294 148.038 1.00 108.61 ? 156 THR B CA  1 
ATOM   1627 C C   . THR B 2 134 ? 160.618 189.506 149.281 1.00 108.61 ? 156 THR B C   1 
ATOM   1628 O O   . THR B 2 134 ? 161.708 188.931 149.352 1.00 108.61 ? 156 THR B O   1 
ATOM   1629 C CB  . THR B 2 134 ? 159.735 189.335 146.951 1.00 108.61 ? 156 THR B CB  1 
ATOM   1630 O OG1 . THR B 2 134 ? 160.854 188.691 146.328 1.00 108.61 ? 156 THR B OG1 1 
ATOM   1631 C CG2 . THR B 2 134 ? 158.942 190.090 145.896 1.00 108.61 ? 156 THR B CG2 1 
ATOM   1632 N N   . ASN B 2 135 ? 159.715 189.482 150.257 1.00 104.49 ? 157 ASN B N   1 
ATOM   1633 C CA  . ASN B 2 135 ? 159.908 188.734 151.492 1.00 104.49 ? 157 ASN B CA  1 
ATOM   1634 C C   . ASN B 2 135 ? 158.873 187.622 151.547 1.00 104.49 ? 157 ASN B C   1 
ATOM   1635 O O   . ASN B 2 135 ? 157.671 187.893 151.640 1.00 104.49 ? 157 ASN B O   1 
ATOM   1636 C CB  . ASN B 2 135 ? 159.795 189.648 152.714 1.00 104.49 ? 157 ASN B CB  1 
ATOM   1637 C CG  . ASN B 2 135 ? 161.138 190.215 153.141 1.00 104.49 ? 157 ASN B CG  1 
ATOM   1638 O OD1 . ASN B 2 135 ? 162.166 189.553 153.002 1.00 104.49 ? 157 ASN B OD1 1 
ATOM   1639 N ND2 . ASN B 2 135 ? 161.141 191.442 153.662 1.00 104.49 ? 157 ASN B ND2 1 
ATOM   1640 N N   . PHE B 2 136 ? 159.337 186.377 151.484 1.00 89.82  ? 158 PHE B N   1 
ATOM   1641 C CA  . PHE B 2 136 ? 158.451 185.223 151.463 1.00 89.82  ? 158 PHE B CA  1 
ATOM   1642 C C   . PHE B 2 136 ? 158.203 184.713 152.876 1.00 89.82  ? 158 PHE B C   1 
ATOM   1643 O O   . PHE B 2 136 ? 159.046 184.863 153.764 1.00 89.82  ? 158 PHE B O   1 
ATOM   1644 C CB  . PHE B 2 136 ? 159.038 184.103 150.604 1.00 89.82  ? 158 PHE B CB  1 
ATOM   1645 C CG  . PHE B 2 136 ? 159.079 184.420 149.139 1.00 89.82  ? 158 PHE B CG  1 
ATOM   1646 C CD1 . PHE B 2 136 ? 157.930 184.350 148.370 1.00 89.82  ? 158 PHE B CD1 1 
ATOM   1647 C CD2 . PHE B 2 136 ? 160.267 184.781 148.528 1.00 89.82  ? 158 PHE B CD2 1 
ATOM   1648 C CE1 . PHE B 2 136 ? 157.964 184.639 147.021 1.00 89.82  ? 158 PHE B CE1 1 
ATOM   1649 C CE2 . PHE B 2 136 ? 160.308 185.071 147.179 1.00 89.82  ? 158 PHE B CE2 1 
ATOM   1650 C CZ  . PHE B 2 136 ? 159.155 185.000 146.425 1.00 89.82  ? 158 PHE B CZ  1 
ATOM   1651 N N   . THR B 2 137 ? 157.036 184.106 153.073 1.00 80.20  ? 159 THR B N   1 
ATOM   1652 C CA  . THR B 2 137 ? 156.643 183.571 154.368 1.00 80.20  ? 159 THR B CA  1 
ATOM   1653 C C   . THR B 2 137 ? 155.576 182.515 154.133 1.00 80.20  ? 159 THR B C   1 
ATOM   1654 O O   . THR B 2 137 ? 154.691 182.709 153.296 1.00 80.20  ? 159 THR B O   1 
ATOM   1655 C CB  . THR B 2 137 ? 156.113 184.679 155.287 1.00 80.20  ? 159 THR B CB  1 
ATOM   1656 O OG1 . THR B 2 137 ? 157.187 185.554 155.652 1.00 80.20  ? 159 THR B OG1 1 
ATOM   1657 C CG2 . THR B 2 137 ? 155.492 184.094 156.548 1.00 80.20  ? 159 THR B CG2 1 
ATOM   1658 N N   . LEU B 2 138 ? 155.665 181.401 154.853 1.00 67.01  ? 160 LEU B N   1 
ATOM   1659 C CA  . LEU B 2 138 ? 154.678 180.334 154.757 1.00 67.01  ? 160 LEU B CA  1 
ATOM   1660 C C   . LEU B 2 138 ? 154.021 180.125 156.112 1.00 67.01  ? 160 LEU B C   1 
ATOM   1661 O O   . LEU B 2 138 ? 154.689 180.173 157.150 1.00 67.01  ? 160 LEU B O   1 
ATOM   1662 C CB  . LEU B 2 138 ? 155.304 179.028 154.259 1.00 67.01  ? 160 LEU B CB  1 
ATOM   1663 C CG  . LEU B 2 138 ? 156.223 178.214 155.169 1.00 67.01  ? 160 LEU B CG  1 
ATOM   1664 C CD1 . LEU B 2 138 ? 156.337 176.791 154.658 1.00 67.01  ? 160 LEU B CD1 1 
ATOM   1665 C CD2 . LEU B 2 138 ? 157.588 178.850 155.218 1.00 67.01  ? 160 LEU B CD2 1 
ATOM   1666 N N   . LYS B 2 139 ? 152.711 179.906 156.094 1.00 62.63  ? 161 LYS B N   1 
ATOM   1667 C CA  . LYS B 2 139 ? 151.943 179.666 157.304 1.00 62.63  ? 161 LYS B CA  1 
ATOM   1668 C C   . LYS B 2 139 ? 151.742 178.171 157.500 1.00 62.63  ? 161 LYS B C   1 
ATOM   1669 O O   . LYS B 2 139 ? 151.396 177.448 156.562 1.00 62.63  ? 161 LYS B O   1 
ATOM   1670 C CB  . LYS B 2 139 ? 150.588 180.370 157.227 1.00 62.63  ? 161 LYS B CB  1 
ATOM   1671 C CG  . LYS B 2 139 ? 149.814 180.403 158.536 1.00 62.63  ? 161 LYS B CG  1 
ATOM   1672 C CD  . LYS B 2 139 ? 150.397 181.412 159.507 1.00 62.63  ? 161 LYS B CD  1 
ATOM   1673 C CE  . LYS B 2 139 ? 149.364 181.853 160.530 1.00 62.63  ? 161 LYS B CE  1 
ATOM   1674 N NZ  . LYS B 2 139 ? 148.758 180.694 161.238 1.00 62.63  ? 161 LYS B NZ  1 
ATOM   1675 N N   . SER B 2 140 ? 151.961 177.712 158.728 1.00 55.51  ? 162 SER B N   1 
ATOM   1676 C CA  . SER B 2 140 ? 151.747 176.318 159.088 1.00 55.51  ? 162 SER B CA  1 
ATOM   1677 C C   . SER B 2 140 ? 150.866 176.280 160.323 1.00 55.51  ? 162 SER B C   1 
ATOM   1678 O O   . SER B 2 140 ? 151.132 176.990 161.297 1.00 55.51  ? 162 SER B O   1 
ATOM   1679 C CB  . SER B 2 140 ? 153.074 175.598 159.348 1.00 55.51  ? 162 SER B CB  1 
ATOM   1680 O OG  . SER B 2 140 ? 153.963 176.419 160.084 1.00 55.51  ? 162 SER B OG  1 
ATOM   1681 N N   . GLU B 2 141 ? 149.824 175.456 160.285 1.00 54.24  ? 163 GLU B N   1 
ATOM   1682 C CA  . GLU B 2 141 ? 148.847 175.462 161.363 1.00 54.24  ? 163 GLU B CA  1 
ATOM   1683 C C   . GLU B 2 141 ? 148.146 174.115 161.417 1.00 54.24  ? 163 GLU B C   1 
ATOM   1684 O O   . GLU B 2 141 ? 148.034 173.407 160.413 1.00 54.24  ? 163 GLU B O   1 
ATOM   1685 C CB  . GLU B 2 141 ? 147.821 176.584 161.180 1.00 54.24  ? 163 GLU B CB  1 
ATOM   1686 C CG  . GLU B 2 141 ? 146.875 176.359 160.011 1.00 54.24  ? 163 GLU B CG  1 
ATOM   1687 C CD  . GLU B 2 141 ? 145.893 177.495 159.823 1.00 54.24  ? 163 GLU B CD  1 
ATOM   1688 O OE1 . GLU B 2 141 ? 146.000 178.504 160.551 1.00 54.24  ? 163 GLU B OE1 1 
ATOM   1689 O OE2 . GLU B 2 141 ? 145.010 177.378 158.947 1.00 54.24  ? 163 GLU B OE2 1 
ATOM   1690 N N   . TRP B 2 142 ? 147.678 173.775 162.610 1.00 47.24  ? 164 TRP B N   1 
ATOM   1691 C CA  . TRP B 2 142 ? 146.820 172.620 162.816 1.00 47.24  ? 164 TRP B CA  1 
ATOM   1692 C C   . TRP B 2 142 ? 145.364 173.042 162.641 1.00 47.24  ? 164 TRP B C   1 
ATOM   1693 O O   . TRP B 2 142 ? 145.063 174.133 162.148 1.00 47.24  ? 164 TRP B O   1 
ATOM   1694 C CB  . TRP B 2 142 ? 147.060 172.014 164.191 1.00 47.24  ? 164 TRP B CB  1 
ATOM   1695 C CG  . TRP B 2 142 ? 148.362 171.301 164.349 1.00 47.24  ? 164 TRP B CG  1 
ATOM   1696 C CD1 . TRP B 2 142 ? 149.238 170.963 163.362 1.00 47.24  ? 164 TRP B CD1 1 
ATOM   1697 C CD2 . TRP B 2 142 ? 148.930 170.821 165.572 1.00 47.24  ? 164 TRP B CD2 1 
ATOM   1698 N NE1 . TRP B 2 142 ? 150.321 170.309 163.895 1.00 47.24  ? 164 TRP B NE1 1 
ATOM   1699 C CE2 . TRP B 2 142 ? 150.156 170.208 165.252 1.00 47.24  ? 164 TRP B CE2 1 
ATOM   1700 C CE3 . TRP B 2 142 ? 148.522 170.854 166.909 1.00 47.24  ? 164 TRP B CE3 1 
ATOM   1701 C CZ2 . TRP B 2 142 ? 150.976 169.634 166.217 1.00 47.24  ? 164 TRP B CZ2 1 
ATOM   1702 C CZ3 . TRP B 2 142 ? 149.338 170.282 167.865 1.00 47.24  ? 164 TRP B CZ3 1 
ATOM   1703 C CH2 . TRP B 2 142 ? 150.551 169.681 167.516 1.00 47.24  ? 164 TRP B CH2 1 
ATOM   1704 N N   . ALA B 2 143 ? 144.436 172.174 163.045 1.00 50.81  ? 165 ALA B N   1 
ATOM   1705 C CA  . ALA B 2 143 ? 143.029 172.557 163.050 1.00 50.81  ? 165 ALA B CA  1 
ATOM   1706 C C   . ALA B 2 143 ? 142.720 173.539 164.173 1.00 50.81  ? 165 ALA B C   1 
ATOM   1707 O O   . ALA B 2 143 ? 141.761 174.312 164.071 1.00 50.81  ? 165 ALA B O   1 
ATOM   1708 C CB  . ALA B 2 143 ? 142.144 171.319 163.172 1.00 50.81  ? 165 ALA B CB  1 
ATOM   1709 N N   . THR B 2 144 ? 143.514 173.526 165.247 1.00 45.86  ? 166 THR B N   1 
ATOM   1710 C CA  . THR B 2 144 ? 143.286 174.397 166.391 1.00 45.86  ? 166 THR B CA  1 
ATOM   1711 C C   . THR B 2 144 ? 144.488 175.243 166.777 1.00 45.86  ? 166 THR B C   1 
ATOM   1712 O O   . THR B 2 144 ? 144.303 176.292 167.404 1.00 45.86  ? 166 THR B O   1 
ATOM   1713 C CB  . THR B 2 144 ? 142.862 173.577 167.619 1.00 45.86  ? 166 THR B CB  1 
ATOM   1714 O OG1 . THR B 2 144 ? 143.890 172.633 167.943 1.00 45.86  ? 166 THR B OG1 1 
ATOM   1715 C CG2 . THR B 2 144 ? 141.569 172.839 167.347 1.00 45.86  ? 166 THR B CG2 1 
ATOM   1716 N N   . HIS B 2 145 ? 145.704 174.829 166.435 1.00 48.60  ? 167 HIS B N   1 
ATOM   1717 C CA  . HIS B 2 145 ? 146.915 175.527 166.840 1.00 48.60  ? 167 HIS B CA  1 
ATOM   1718 C C   . HIS B 2 145 ? 147.539 176.204 165.630 1.00 48.60  ? 167 HIS B C   1 
ATOM   1719 O O   . HIS B 2 145 ? 147.664 175.589 164.566 1.00 48.60  ? 167 HIS B O   1 
ATOM   1720 C CB  . HIS B 2 145 ? 147.913 174.563 167.483 1.00 48.60  ? 167 HIS B CB  1 
ATOM   1721 C CG  . HIS B 2 145 ? 149.071 175.243 168.141 1.00 48.60  ? 167 HIS B CG  1 
ATOM   1722 N ND1 . HIS B 2 145 ? 149.016 175.725 169.430 1.00 48.60  ? 167 HIS B ND1 1 
ATOM   1723 C CD2 . HIS B 2 145 ? 150.316 175.521 167.688 1.00 48.60  ? 167 HIS B CD2 1 
ATOM   1724 C CE1 . HIS B 2 145 ? 150.177 176.271 169.744 1.00 48.60  ? 167 HIS B CE1 1 
ATOM   1725 N NE2 . HIS B 2 145 ? 150.984 176.160 168.704 1.00 48.60  ? 167 HIS B NE2 1 
ATOM   1726 N N   . LYS B 2 146 ? 147.925 177.465 165.795 1.00 54.17  ? 168 LYS B N   1 
ATOM   1727 C CA  . LYS B 2 146 ? 148.567 178.245 164.744 1.00 54.17  ? 168 LYS B CA  1 
ATOM   1728 C C   . LYS B 2 146 ? 150.028 178.451 165.118 1.00 54.17  ? 168 LYS B C   1 
ATOM   1729 O O   . LYS B 2 146 ? 150.332 179.163 166.081 1.00 54.17  ? 168 LYS B O   1 
ATOM   1730 C CB  . LYS B 2 146 ? 147.864 179.588 164.548 1.00 54.17  ? 168 LYS B CB  1 
ATOM   1731 C CG  . LYS B 2 146 ? 146.660 179.536 163.619 1.00 54.17  ? 168 LYS B CG  1 
ATOM   1732 C CD  . LYS B 2 146 ? 145.453 178.912 164.299 1.00 54.17  ? 168 LYS B CD  1 
ATOM   1733 C CE  . LYS B 2 146 ? 144.256 178.865 163.365 1.00 54.17  ? 168 LYS B CE  1 
ATOM   1734 N NZ  . LYS B 2 146 ? 143.095 178.167 163.983 1.00 54.17  ? 168 LYS B NZ  1 
ATOM   1735 N N   . PHE B 2 147 ? 150.926 177.834 164.356 1.00 53.88  ? 169 PHE B N   1 
ATOM   1736 C CA  . PHE B 2 147 ? 152.345 177.876 164.667 1.00 53.88  ? 169 PHE B CA  1 
ATOM   1737 C C   . PHE B 2 147 ? 152.947 179.214 164.245 1.00 53.88  ? 169 PHE B C   1 
ATOM   1738 O O   . PHE B 2 147 ? 152.262 180.108 163.742 1.00 53.88  ? 169 PHE B O   1 
ATOM   1739 C CB  . PHE B 2 147 ? 153.070 176.716 163.990 1.00 53.88  ? 169 PHE B CB  1 
ATOM   1740 C CG  . PHE B 2 147 ? 152.757 175.375 164.585 1.00 53.88  ? 169 PHE B CG  1 
ATOM   1741 C CD1 . PHE B 2 147 ? 153.606 174.801 165.512 1.00 53.88  ? 169 PHE B CD1 1 
ATOM   1742 C CD2 . PHE B 2 147 ? 151.615 174.688 164.214 1.00 53.88  ? 169 PHE B CD2 1 
ATOM   1743 C CE1 . PHE B 2 147 ? 153.323 173.568 166.060 1.00 53.88  ? 169 PHE B CE1 1 
ATOM   1744 C CE2 . PHE B 2 147 ? 151.326 173.456 164.759 1.00 53.88  ? 169 PHE B CE2 1 
ATOM   1745 C CZ  . PHE B 2 147 ? 152.181 172.895 165.683 1.00 53.88  ? 169 PHE B CZ  1 
ATOM   1746 N N   . ALA B 2 148 ? 154.254 179.348 164.452 1.00 68.74  ? 170 ALA B N   1 
ATOM   1747 C CA  . ALA B 2 148 ? 154.972 180.552 164.071 1.00 68.74  ? 170 ALA B CA  1 
ATOM   1748 C C   . ALA B 2 148 ? 155.196 180.585 162.560 1.00 68.74  ? 170 ALA B C   1 
ATOM   1749 O O   . ALA B 2 148 ? 154.808 179.674 161.824 1.00 68.74  ? 170 ALA B O   1 
ATOM   1750 C CB  . ALA B 2 148 ? 156.305 180.637 164.812 1.00 68.74  ? 170 ALA B CB  1 
ATOM   1751 N N   . ASP B 2 149 ? 155.832 181.657 162.099 1.00 76.31  ? 171 ASP B N   1 
ATOM   1752 C CA  . ASP B 2 149 ? 156.073 181.872 160.682 1.00 76.31  ? 171 ASP B CA  1 
ATOM   1753 C C   . ASP B 2 149 ? 157.566 181.858 160.379 1.00 76.31  ? 171 ASP B C   1 
ATOM   1754 O O   . ASP B 2 149 ? 158.406 182.100 161.250 1.00 76.31  ? 171 ASP B O   1 
ATOM   1755 C CB  . ASP B 2 149 ? 155.465 183.201 160.222 1.00 76.31  ? 171 ASP B CB  1 
ATOM   1756 C CG  . ASP B 2 149 ? 153.956 183.211 160.319 1.00 76.31  ? 171 ASP B CG  1 
ATOM   1757 O OD1 . ASP B 2 149 ? 153.355 182.120 160.264 1.00 76.31  ? 171 ASP B OD1 1 
ATOM   1758 O OD2 . ASP B 2 149 ? 153.371 184.307 160.447 1.00 76.31  ? 171 ASP B OD2 1 
ATOM   1759 N N   . CYS B 2 150 ? 157.885 181.570 159.122 1.00 87.68  ? 172 CYS B N   1 
ATOM   1760 C CA  . CYS B 2 150 ? 159.243 181.655 158.608 1.00 87.68  ? 172 CYS B CA  1 
ATOM   1761 C C   . CYS B 2 150 ? 159.476 183.007 157.949 1.00 87.68  ? 172 CYS B C   1 
ATOM   1762 O O   . CYS B 2 150 ? 158.554 183.802 157.753 1.00 87.68  ? 172 CYS B O   1 
ATOM   1763 C CB  . CYS B 2 150 ? 159.523 180.546 157.590 1.00 87.68  ? 172 CYS B CB  1 
ATOM   1764 S SG  . CYS B 2 150 ? 160.045 178.949 158.244 1.00 87.68  ? 172 CYS B SG  1 
ATOM   1765 N N   . LYS B 2 151 ? 160.737 183.257 157.606 1.00 91.37  ? 173 LYS B N   1 
ATOM   1766 C CA  . LYS B 2 151 ? 161.128 184.416 156.815 1.00 91.37  ? 173 LYS B CA  1 
ATOM   1767 C C   . LYS B 2 151 ? 162.185 183.965 155.820 1.00 91.37  ? 173 LYS B C   1 
ATOM   1768 O O   . LYS B 2 151 ? 163.180 183.347 156.211 1.00 91.37  ? 173 LYS B O   1 
ATOM   1769 C CB  . LYS B 2 151 ? 161.660 185.547 157.699 1.00 91.37  ? 173 LYS B CB  1 
ATOM   1770 C CG  . LYS B 2 151 ? 160.577 186.312 158.443 1.00 91.37  ? 173 LYS B CG  1 
ATOM   1771 C CD  . LYS B 2 151 ? 159.543 186.877 157.482 1.00 91.37  ? 173 LYS B CD  1 
ATOM   1772 C CE  . LYS B 2 151 ? 159.647 188.388 157.373 1.00 91.37  ? 173 LYS B CE  1 
ATOM   1773 N NZ  . LYS B 2 151 ? 158.460 188.977 156.692 1.00 91.37  ? 173 LYS B NZ  1 
ATOM   1774 N N   . ALA B 2 152 ? 161.961 184.253 154.542 1.00 96.48  ? 174 ALA B N   1 
ATOM   1775 C CA  . ALA B 2 152 ? 162.914 183.864 153.512 1.00 96.48  ? 174 ALA B CA  1 
ATOM   1776 C C   . ALA B 2 152 ? 164.226 184.612 153.699 1.00 96.48  ? 174 ALA B C   1 
ATOM   1777 O O   . ALA B 2 152 ? 164.285 185.834 153.529 1.00 96.48  ? 174 ALA B O   1 
ATOM   1778 C CB  . ALA B 2 152 ? 162.334 184.140 152.126 1.00 96.48  ? 174 ALA B CB  1 
ATOM   1779 N N   . LYS B 2 153 ? 165.276 183.876 154.057 1.00 102.12 ? 175 LYS B N   1 
ATOM   1780 C CA  . LYS B 2 153 ? 166.589 184.479 154.229 1.00 102.12 ? 175 LYS B CA  1 
ATOM   1781 C C   . LYS B 2 153 ? 167.090 185.046 152.904 1.00 102.12 ? 175 LYS B C   1 
ATOM   1782 O O   . LYS B 2 153 ? 166.704 184.602 151.819 1.00 102.12 ? 175 LYS B O   1 
ATOM   1783 C CB  . LYS B 2 153 ? 167.593 183.456 154.768 1.00 102.12 ? 175 LYS B CB  1 
ATOM   1784 C CG  . LYS B 2 153 ? 167.069 182.507 155.846 1.00 102.12 ? 175 LYS B CG  1 
ATOM   1785 C CD  . LYS B 2 153 ? 166.260 183.217 156.925 1.00 102.12 ? 175 LYS B CD  1 
ATOM   1786 C CE  . LYS B 2 153 ? 167.162 183.880 157.953 1.00 102.12 ? 175 LYS B CE  1 
ATOM   1787 N NZ  . LYS B 2 153 ? 166.463 184.071 159.255 1.00 102.12 ? 175 LYS B NZ  1 
ATOM   1788 N N   . ARG B 2 154 ? 167.967 186.048 153.003 1.00 106.04 ? 176 ARG B N   1 
ATOM   1789 C CA  . ARG B 2 154 ? 168.515 186.661 151.798 1.00 106.04 ? 176 ARG B CA  1 
ATOM   1790 C C   . ARG B 2 154 ? 169.450 185.713 151.060 1.00 106.04 ? 176 ARG B C   1 
ATOM   1791 O O   . ARG B 2 154 ? 169.668 185.874 149.853 1.00 106.04 ? 176 ARG B O   1 
ATOM   1792 C CB  . ARG B 2 154 ? 169.239 187.960 152.149 1.00 106.04 ? 176 ARG B CB  1 
ATOM   1793 C CG  . ARG B 2 154 ? 168.306 189.127 152.435 1.00 106.04 ? 176 ARG B CG  1 
ATOM   1794 C CD  . ARG B 2 154 ? 167.285 189.302 151.320 1.00 106.04 ? 176 ARG B CD  1 
ATOM   1795 N NE  . ARG B 2 154 ? 166.769 190.666 151.248 1.00 106.04 ? 176 ARG B NE  1 
ATOM   1796 C CZ  . ARG B 2 154 ? 165.723 191.107 151.940 1.00 106.04 ? 176 ARG B CZ  1 
ATOM   1797 N NH1 . ARG B 2 154 ? 165.079 190.291 152.763 1.00 106.04 ? 176 ARG B NH1 1 
ATOM   1798 N NH2 . ARG B 2 154 ? 165.321 192.364 151.811 1.00 106.04 ? 176 ARG B NH2 1 
ATOM   1799 N N   . ASP B 2 155 ? 170.013 184.726 151.759 1.00 104.39 ? 177 ASP B N   1 
ATOM   1800 C CA  . ASP B 2 155 ? 170.868 183.748 151.095 1.00 104.39 ? 177 ASP B CA  1 
ATOM   1801 C C   . ASP B 2 155 ? 170.032 182.772 150.276 1.00 104.39 ? 177 ASP B C   1 
ATOM   1802 O O   . ASP B 2 155 ? 170.284 182.572 149.082 1.00 104.39 ? 177 ASP B O   1 
ATOM   1803 C CB  . ASP B 2 155 ? 171.714 183.011 152.138 1.00 104.39 ? 177 ASP B CB  1 
ATOM   1804 C CG  . ASP B 2 155 ? 172.804 182.144 151.520 1.00 104.39 ? 177 ASP B CG  1 
ATOM   1805 O OD1 . ASP B 2 155 ? 172.618 181.609 150.407 1.00 104.39 ? 177 ASP B OD1 1 
ATOM   1806 O OD2 . ASP B 2 155 ? 173.863 181.995 152.164 1.00 104.39 ? 177 ASP B OD2 1 
ATOM   1807 N N   . THR B 2 156 ? 169.028 182.161 150.900 1.00 99.04  ? 178 THR B N   1 
ATOM   1808 C CA  . THR B 2 156 ? 168.148 181.203 150.234 1.00 99.04  ? 178 THR B CA  1 
ATOM   1809 C C   . THR B 2 156 ? 166.705 181.640 150.444 1.00 99.04  ? 178 THR B C   1 
ATOM   1810 O O   . THR B 2 156 ? 166.113 181.352 151.499 1.00 99.04  ? 178 THR B O   1 
ATOM   1811 C CB  . THR B 2 156 ? 168.364 179.790 150.761 1.00 99.04  ? 178 THR B CB  1 
ATOM   1812 O OG1 . THR B 2 156 ? 168.481 179.824 152.189 1.00 99.04  ? 178 THR B OG1 1 
ATOM   1813 C CG2 . THR B 2 156 ? 169.630 179.190 150.166 1.00 99.04  ? 178 THR B CG2 1 
ATOM   1814 N N   . PRO B 2 157 ? 166.107 182.331 149.476 1.00 95.67  ? 179 PRO B N   1 
ATOM   1815 C CA  . PRO B 2 157 ? 164.724 182.805 149.626 1.00 95.67  ? 179 PRO B CA  1 
ATOM   1816 C C   . PRO B 2 157 ? 163.650 181.774 149.308 1.00 95.67  ? 179 PRO B C   1 
ATOM   1817 O O   . PRO B 2 157 ? 162.487 182.160 149.155 1.00 95.67  ? 179 PRO B O   1 
ATOM   1818 C CB  . PRO B 2 157 ? 164.668 183.957 148.614 1.00 95.67  ? 179 PRO B CB  1 
ATOM   1819 C CG  . PRO B 2 157 ? 165.591 183.525 147.530 1.00 95.67  ? 179 PRO B CG  1 
ATOM   1820 C CD  . PRO B 2 157 ? 166.707 182.764 148.202 1.00 95.67  ? 179 PRO B CD  1 
ATOM   1821 N N   . THR B 2 158 ? 163.996 180.488 149.203 1.00 89.68  ? 180 THR B N   1 
ATOM   1822 C CA  . THR B 2 158 ? 163.027 179.456 148.851 1.00 89.68  ? 180 THR B CA  1 
ATOM   1823 C C   . THR B 2 158 ? 163.064 178.272 149.812 1.00 89.68  ? 180 THR B C   1 
ATOM   1824 O O   . THR B 2 158 ? 162.582 177.189 149.465 1.00 89.68  ? 180 THR B O   1 
ATOM   1825 C CB  . THR B 2 158 ? 163.251 178.965 147.418 1.00 89.68  ? 180 THR B CB  1 
ATOM   1826 O OG1 . THR B 2 158 ? 164.593 178.481 147.281 1.00 89.68  ? 180 THR B OG1 1 
ATOM   1827 C CG2 . THR B 2 158 ? 163.016 180.089 146.420 1.00 89.68  ? 180 THR B CG2 1 
ATOM   1828 N N   . SER B 2 159 ? 163.622 178.446 151.009 1.00 88.09  ? 181 SER B N   1 
ATOM   1829 C CA  . SER B 2 159 ? 163.708 177.346 151.962 1.00 88.09  ? 181 SER B CA  1 
ATOM   1830 C C   . SER B 2 159 ? 163.900 177.903 153.364 1.00 88.09  ? 181 SER B C   1 
ATOM   1831 O O   . SER B 2 159 ? 164.689 178.833 153.559 1.00 88.09  ? 181 SER B O   1 
ATOM   1832 C CB  . SER B 2 159 ? 164.859 176.400 151.604 1.00 88.09  ? 181 SER B CB  1 
ATOM   1833 O OG  . SER B 2 159 ? 166.028 177.126 151.269 1.00 88.09  ? 181 SER B OG  1 
ATOM   1834 N N   . CYS B 2 160 ? 163.181 177.335 154.330 1.00 85.72  ? 182 CYS B N   1 
ATOM   1835 C CA  . CYS B 2 160 ? 163.356 177.680 155.733 1.00 85.72  ? 182 CYS B CA  1 
ATOM   1836 C C   . CYS B 2 160 ? 163.270 176.411 156.566 1.00 85.72  ? 182 CYS B C   1 
ATOM   1837 O O   . CYS B 2 160 ? 162.777 175.376 156.112 1.00 85.72  ? 182 CYS B O   1 
ATOM   1838 C CB  . CYS B 2 160 ? 162.305 178.685 156.222 1.00 85.72  ? 182 CYS B CB  1 
ATOM   1839 S SG  . CYS B 2 160 ? 160.694 177.950 156.595 1.00 85.72  ? 182 CYS B SG  1 
ATOM   1840 N N   . THR B 2 161 ? 163.757 176.505 157.799 1.00 80.01  ? 183 THR B N   1 
ATOM   1841 C CA  . THR B 2 161 ? 163.658 175.428 158.776 1.00 80.01  ? 183 THR B CA  1 
ATOM   1842 C C   . THR B 2 161 ? 162.765 175.898 159.916 1.00 80.01  ? 183 THR B C   1 
ATOM   1843 O O   . THR B 2 161 ? 163.082 176.885 160.588 1.00 80.01  ? 183 THR B O   1 
ATOM   1844 C CB  . THR B 2 161 ? 165.037 175.026 159.297 1.00 80.01  ? 183 THR B CB  1 
ATOM   1845 O OG1 . THR B 2 161 ? 165.964 174.970 158.205 1.00 80.01  ? 183 THR B OG1 1 
ATOM   1846 C CG2 . THR B 2 161 ? 164.975 173.662 159.967 1.00 80.01  ? 183 THR B CG2 1 
ATOM   1847 N N   . VAL B 2 162 ? 161.648 175.195 160.125 1.00 68.99  ? 184 VAL B N   1 
ATOM   1848 C CA  . VAL B 2 162 ? 160.703 175.610 161.152 1.00 68.99  ? 184 VAL B CA  1 
ATOM   1849 C C   . VAL B 2 162 ? 161.333 175.477 162.538 1.00 68.99  ? 184 VAL B C   1 
ATOM   1850 O O   . VAL B 2 162 ? 162.344 174.792 162.736 1.00 68.99  ? 184 VAL B O   1 
ATOM   1851 C CB  . VAL B 2 162 ? 159.399 174.803 161.059 1.00 68.99  ? 184 VAL B CB  1 
ATOM   1852 C CG1 . VAL B 2 162 ? 158.841 174.865 159.648 1.00 68.99  ? 184 VAL B CG1 1 
ATOM   1853 C CG2 . VAL B 2 162 ? 159.635 173.364 161.483 1.00 68.99  ? 184 VAL B CG2 1 
ATOM   1854 N N   . ASP B 2 163 ? 160.718 176.151 163.511 1.00 68.31  ? 185 ASP B N   1 
ATOM   1855 C CA  . ASP B 2 163 ? 161.246 176.236 164.867 1.00 68.31  ? 185 ASP B CA  1 
ATOM   1856 C C   . ASP B 2 163 ? 160.443 175.411 165.869 1.00 68.31  ? 185 ASP B C   1 
ATOM   1857 O O   . ASP B 2 163 ? 160.627 175.567 167.080 1.00 68.31  ? 185 ASP B O   1 
ATOM   1858 C CB  . ASP B 2 163 ? 161.307 177.698 165.313 1.00 68.31  ? 185 ASP B CB  1 
ATOM   1859 C CG  . ASP B 2 163 ? 160.004 178.441 165.069 1.00 68.31  ? 185 ASP B CG  1 
ATOM   1860 O OD1 . ASP B 2 163 ? 160.052 179.676 164.891 1.00 68.31  ? 185 ASP B OD1 1 
ATOM   1861 O OD2 . ASP B 2 163 ? 158.934 177.797 165.048 1.00 68.31  ? 185 ASP B OD2 1 
ATOM   1862 N N   . TYR B 2 164 ? 159.559 174.538 165.395 1.00 62.24  ? 186 TYR B N   1 
ATOM   1863 C CA  . TYR B 2 164 ? 158.743 173.709 166.267 1.00 62.24  ? 186 TYR B CA  1 
ATOM   1864 C C   . TYR B 2 164 ? 159.045 172.237 166.023 1.00 62.24  ? 186 TYR B C   1 
ATOM   1865 O O   . TYR B 2 164 ? 159.424 171.837 164.919 1.00 62.24  ? 186 TYR B O   1 
ATOM   1866 C CB  . TYR B 2 164 ? 157.247 173.977 166.058 1.00 62.24  ? 186 TYR B CB  1 
ATOM   1867 C CG  . TYR B 2 164 ? 156.815 173.986 164.610 1.00 62.24  ? 186 TYR B CG  1 
ATOM   1868 C CD1 . TYR B 2 164 ? 156.678 175.178 163.915 1.00 62.24  ? 186 TYR B CD1 1 
ATOM   1869 C CD2 . TYR B 2 164 ? 156.540 172.802 163.939 1.00 62.24  ? 186 TYR B CD2 1 
ATOM   1870 C CE1 . TYR B 2 164 ? 156.280 175.193 162.594 1.00 62.24  ? 186 TYR B CE1 1 
ATOM   1871 C CE2 . TYR B 2 164 ? 156.144 172.806 162.618 1.00 62.24  ? 186 TYR B CE2 1 
ATOM   1872 C CZ  . TYR B 2 164 ? 156.016 174.004 161.950 1.00 62.24  ? 186 TYR B CZ  1 
ATOM   1873 O OH  . TYR B 2 164 ? 155.621 174.013 160.633 1.00 62.24  ? 186 TYR B OH  1 
ATOM   1874 N N   . SER B 2 165 ? 158.870 171.435 167.070 1.00 60.88  ? 187 SER B N   1 
ATOM   1875 C CA  . SER B 2 165 ? 159.123 170.006 166.971 1.00 60.88  ? 187 SER B CA  1 
ATOM   1876 C C   . SER B 2 165 ? 158.014 169.314 166.187 1.00 60.88  ? 187 SER B C   1 
ATOM   1877 O O   . SER B 2 165 ? 156.844 169.703 166.242 1.00 60.88  ? 187 SER B O   1 
ATOM   1878 C CB  . SER B 2 165 ? 159.242 169.391 168.364 1.00 60.88  ? 187 SER B CB  1 
ATOM   1879 O OG  . SER B 2 165 ? 158.216 169.864 169.218 1.00 60.88  ? 187 SER B OG  1 
ATOM   1880 N N   . THR B 2 166 ? 158.396 168.273 165.453 1.00 53.66  ? 188 THR B N   1 
ATOM   1881 C CA  . THR B 2 166 ? 157.453 167.550 164.612 1.00 53.66  ? 188 THR B CA  1 
ATOM   1882 C C   . THR B 2 166 ? 156.662 166.539 165.430 1.00 53.66  ? 188 THR B C   1 
ATOM   1883 O O   . THR B 2 166 ? 157.208 165.851 166.296 1.00 53.66  ? 188 THR B O   1 
ATOM   1884 C CB  . THR B 2 166 ? 158.188 166.837 163.478 1.00 53.66  ? 188 THR B CB  1 
ATOM   1885 O OG1 . THR B 2 166 ? 159.170 165.950 164.027 1.00 53.66  ? 188 THR B OG1 1 
ATOM   1886 C CG2 . THR B 2 166 ? 158.876 167.847 162.574 1.00 53.66  ? 188 THR B CG2 1 
ATOM   1887 N N   . VAL B 2 167 ? 155.365 166.454 165.146 1.00 45.92  ? 189 VAL B N   1 
ATOM   1888 C CA  . VAL B 2 167 ? 154.466 165.508 165.794 1.00 45.92  ? 189 VAL B CA  1 
ATOM   1889 C C   . VAL B 2 167 ? 153.818 164.666 164.706 1.00 45.92  ? 189 VAL B C   1 
ATOM   1890 O O   . VAL B 2 167 ? 153.154 165.204 163.811 1.00 45.92  ? 189 VAL B O   1 
ATOM   1891 C CB  . VAL B 2 167 ? 153.402 166.217 166.645 1.00 45.92  ? 189 VAL B CB  1 
ATOM   1892 C CG1 . VAL B 2 167 ? 152.441 165.204 167.244 1.00 45.92  ? 189 VAL B CG1 1 
ATOM   1893 C CG2 . VAL B 2 167 ? 154.061 167.042 167.736 1.00 45.92  ? 189 VAL B CG2 1 
ATOM   1894 N N   . TYR B 2 168 ? 154.008 163.353 164.782 1.00 39.42  ? 190 TYR B N   1 
ATOM   1895 C CA  . TYR B 2 168 ? 153.488 162.455 163.765 1.00 39.42  ? 190 TYR B CA  1 
ATOM   1896 C C   . TYR B 2 168 ? 152.009 162.166 164.001 1.00 39.42  ? 190 TYR B C   1 
ATOM   1897 O O   . TYR B 2 168 ? 151.462 162.412 165.079 1.00 39.42  ? 190 TYR B O   1 
ATOM   1898 C CB  . TYR B 2 168 ? 154.282 161.150 163.749 1.00 39.42  ? 190 TYR B CB  1 
ATOM   1899 C CG  . TYR B 2 168 ? 155.773 161.342 163.586 1.00 39.42  ? 190 TYR B CG  1 
ATOM   1900 C CD1 . TYR B 2 168 ? 156.346 161.439 162.326 1.00 39.42  ? 190 TYR B CD1 1 
ATOM   1901 C CD2 . TYR B 2 168 ? 156.606 161.423 164.691 1.00 39.42  ? 190 TYR B CD2 1 
ATOM   1902 C CE1 . TYR B 2 168 ? 157.706 161.614 162.173 1.00 39.42  ? 190 TYR B CE1 1 
ATOM   1903 C CE2 . TYR B 2 168 ? 157.968 161.597 164.547 1.00 39.42  ? 190 TYR B CE2 1 
ATOM   1904 C CZ  . TYR B 2 168 ? 158.512 161.692 163.286 1.00 39.42  ? 190 TYR B CZ  1 
ATOM   1905 O OH  . TYR B 2 168 ? 159.868 161.866 163.137 1.00 39.42  ? 190 TYR B OH  1 
ATOM   1906 N N   . PHE B 2 169 ? 151.361 161.641 162.959 1.00 38.52  ? 191 PHE B N   1 
ATOM   1907 C CA  . PHE B 2 169 ? 149.957 161.236 162.997 1.00 38.52  ? 191 PHE B CA  1 
ATOM   1908 C C   . PHE B 2 169 ? 149.020 162.404 163.297 1.00 38.52  ? 191 PHE B C   1 
ATOM   1909 O O   . PHE B 2 169 ? 147.983 162.224 163.937 1.00 38.52  ? 191 PHE B O   1 
ATOM   1910 C CB  . PHE B 2 169 ? 149.731 160.102 164.002 1.00 38.52  ? 191 PHE B CB  1 
ATOM   1911 C CG  . PHE B 2 169 ? 150.676 158.947 163.836 1.00 38.52  ? 191 PHE B CG  1 
ATOM   1912 C CD1 . PHE B 2 169 ? 150.540 158.071 162.773 1.00 38.52  ? 191 PHE B CD1 1 
ATOM   1913 C CD2 . PHE B 2 169 ? 151.702 158.738 164.741 1.00 38.52  ? 191 PHE B CD2 1 
ATOM   1914 C CE1 . PHE B 2 169 ? 151.410 157.009 162.616 1.00 38.52  ? 191 PHE B CE1 1 
ATOM   1915 C CE2 . PHE B 2 169 ? 152.574 157.677 164.590 1.00 38.52  ? 191 PHE B CE2 1 
ATOM   1916 C CZ  . PHE B 2 169 ? 152.428 156.812 163.526 1.00 38.52  ? 191 PHE B CZ  1 
ATOM   1917 N N   . VAL B 2 170 ? 149.369 163.604 162.838 1.00 40.34  ? 192 VAL B N   1 
ATOM   1918 C CA  . VAL B 2 170 ? 148.526 164.787 162.980 1.00 40.34  ? 192 VAL B CA  1 
ATOM   1919 C C   . VAL B 2 170 ? 148.595 165.571 161.678 1.00 40.34  ? 192 VAL B C   1 
ATOM   1920 O O   . VAL B 2 170 ? 149.676 166.015 161.274 1.00 40.34  ? 192 VAL B O   1 
ATOM   1921 C CB  . VAL B 2 170 ? 148.952 165.667 164.167 1.00 40.34  ? 192 VAL B CB  1 
ATOM   1922 C CG1 . VAL B 2 170 ? 148.375 167.064 164.024 1.00 40.34  ? 192 VAL B CG1 1 
ATOM   1923 C CG2 . VAL B 2 170 ? 148.503 165.046 165.477 1.00 40.34  ? 192 VAL B CG2 1 
ATOM   1924 N N   . ASN B 2 171 ? 147.447 165.742 161.024 1.00 42.42  ? 193 ASN B N   1 
ATOM   1925 C CA  . ASN B 2 171 ? 147.390 166.425 159.735 1.00 42.42  ? 193 ASN B CA  1 
ATOM   1926 C C   . ASN B 2 171 ? 147.660 167.912 159.926 1.00 42.42  ? 193 ASN B C   1 
ATOM   1927 O O   . ASN B 2 171 ? 146.911 168.603 160.624 1.00 42.42  ? 193 ASN B O   1 
ATOM   1928 C CB  . ASN B 2 171 ? 146.033 166.201 159.079 1.00 42.42  ? 193 ASN B CB  1 
ATOM   1929 C CG  . ASN B 2 171 ? 146.041 165.038 158.111 1.00 42.42  ? 193 ASN B CG  1 
ATOM   1930 O OD1 . ASN B 2 171 ? 147.077 164.698 157.543 1.00 42.42  ? 193 ASN B OD1 1 
ATOM   1931 N ND2 . ASN B 2 171 ? 144.881 164.424 157.914 1.00 42.42  ? 193 ASN B ND2 1 
ATOM   1932 N N   . ILE B 2 172 ? 148.726 168.406 159.307 1.00 41.67  ? 194 ILE B N   1 
ATOM   1933 C CA  . ILE B 2 172 ? 149.085 169.817 159.353 1.00 41.67  ? 194 ILE B CA  1 
ATOM   1934 C C   . ILE B 2 172 ? 148.857 170.424 157.977 1.00 41.67  ? 194 ILE B C   1 
ATOM   1935 O O   . ILE B 2 172 ? 149.112 169.793 156.945 1.00 41.67  ? 194 ILE B O   1 
ATOM   1936 C CB  . ILE B 2 172 ? 150.545 170.001 159.823 1.00 41.67  ? 194 ILE B CB  1 
ATOM   1937 C CG1 . ILE B 2 172 ? 150.914 171.482 159.897 1.00 41.67  ? 194 ILE B CG1 1 
ATOM   1938 C CG2 . ILE B 2 172 ? 151.504 169.250 158.914 1.00 41.67  ? 194 ILE B CG2 1 
ATOM   1939 C CD1 . ILE B 2 172 ? 152.351 171.729 160.296 1.00 41.67  ? 194 ILE B CD1 1 
ATOM   1940 N N   . GLU B 2 173 ? 148.361 171.658 157.956 1.00 49.52  ? 195 GLU B N   1 
ATOM   1941 C CA  . GLU B 2 173 ? 148.073 172.376 156.721 1.00 49.52  ? 195 GLU B CA  1 
ATOM   1942 C C   . GLU B 2 173 ? 149.093 173.489 156.528 1.00 49.52  ? 195 GLU B C   1 
ATOM   1943 O O   . GLU B 2 173 ? 149.272 174.331 157.414 1.00 49.52  ? 195 GLU B O   1 
ATOM   1944 C CB  . GLU B 2 173 ? 146.655 172.951 156.739 1.00 49.52  ? 195 GLU B CB  1 
ATOM   1945 C CG  . GLU B 2 173 ? 146.296 173.741 155.494 1.00 49.52  ? 195 GLU B CG  1 
ATOM   1946 C CD  . GLU B 2 173 ? 144.800 173.906 155.323 1.00 49.52  ? 195 GLU B CD  1 
ATOM   1947 O OE1 . GLU B 2 173 ? 144.380 174.561 154.347 1.00 49.52  ? 195 GLU B OE1 1 
ATOM   1948 O OE2 . GLU B 2 173 ? 144.044 173.377 156.165 1.00 49.52  ? 195 GLU B OE2 1 
ATOM   1949 N N   . VAL B 2 174 ? 149.754 173.492 155.373 1.00 48.69  ? 196 VAL B N   1 
ATOM   1950 C CA  . VAL B 2 174 ? 150.841 174.420 155.087 1.00 48.69  ? 196 VAL B CA  1 
ATOM   1951 C C   . VAL B 2 174 ? 150.546 175.145 153.781 1.00 48.69  ? 196 VAL B C   1 
ATOM   1952 O O   . VAL B 2 174 ? 150.029 174.547 152.832 1.00 48.69  ? 196 VAL B O   1 
ATOM   1953 C CB  . VAL B 2 174 ? 152.199 173.690 155.004 1.00 48.69  ? 196 VAL B CB  1 
ATOM   1954 C CG1 . VAL B 2 174 ? 153.340 174.689 154.911 1.00 48.69  ? 196 VAL B CG1 1 
ATOM   1955 C CG2 . VAL B 2 174 ? 152.388 172.774 156.201 1.00 48.69  ? 196 VAL B CG2 1 
ATOM   1956 N N   . TRP B 2 175 ? 150.874 176.435 153.738 1.00 56.58  ? 197 TRP B N   1 
ATOM   1957 C CA  . TRP B 2 175 ? 150.764 177.221 152.517 1.00 56.58  ? 197 TRP B CA  1 
ATOM   1958 C C   . TRP B 2 175 ? 151.689 178.423 152.627 1.00 56.58  ? 197 TRP B C   1 
ATOM   1959 O O   . TRP B 2 175 ? 151.979 178.906 153.724 1.00 56.58  ? 197 TRP B O   1 
ATOM   1960 C CB  . TRP B 2 175 ? 149.321 177.665 152.255 1.00 56.58  ? 197 TRP B CB  1 
ATOM   1961 C CG  . TRP B 2 175 ? 148.866 178.813 153.105 1.00 56.58  ? 197 TRP B CG  1 
ATOM   1962 C CD1 . TRP B 2 175 ? 149.011 180.142 152.834 1.00 56.58  ? 197 TRP B CD1 1 
ATOM   1963 C CD2 . TRP B 2 175 ? 148.176 178.733 154.357 1.00 56.58  ? 197 TRP B CD2 1 
ATOM   1964 N NE1 . TRP B 2 175 ? 148.462 180.893 153.843 1.00 56.58  ? 197 TRP B NE1 1 
ATOM   1965 C CE2 . TRP B 2 175 ? 147.942 180.051 154.790 1.00 56.58  ? 197 TRP B CE2 1 
ATOM   1966 C CE3 . TRP B 2 175 ? 147.736 177.673 155.156 1.00 56.58  ? 197 TRP B CE3 1 
ATOM   1967 C CZ2 . TRP B 2 175 ? 147.287 180.339 155.985 1.00 56.58  ? 197 TRP B CZ2 1 
ATOM   1968 C CZ3 . TRP B 2 175 ? 147.087 177.961 156.342 1.00 56.58  ? 197 TRP B CZ3 1 
ATOM   1969 C CH2 . TRP B 2 175 ? 146.869 179.282 156.745 1.00 56.58  ? 197 TRP B CH2 1 
ATOM   1970 N N   . VAL B 2 176 ? 152.142 178.904 151.473 1.00 67.62  ? 198 VAL B N   1 
ATOM   1971 C CA  . VAL B 2 176 ? 153.089 180.009 151.385 1.00 67.62  ? 198 VAL B CA  1 
ATOM   1972 C C   . VAL B 2 176 ? 152.355 181.251 150.900 1.00 67.62  ? 198 VAL B C   1 
ATOM   1973 O O   . VAL B 2 176 ? 151.550 181.182 149.964 1.00 67.62  ? 198 VAL B O   1 
ATOM   1974 C CB  . VAL B 2 176 ? 154.263 179.671 150.446 1.00 67.62  ? 198 VAL B CB  1 
ATOM   1975 C CG1 . VAL B 2 176 ? 155.362 180.714 150.570 1.00 67.62  ? 198 VAL B CG1 1 
ATOM   1976 C CG2 . VAL B 2 176 ? 154.797 178.282 150.745 1.00 67.62  ? 198 VAL B CG2 1 
ATOM   1977 N N   . GLU B 2 177 ? 152.637 182.386 151.536 1.00 74.08  ? 199 GLU B N   1 
ATOM   1978 C CA  . GLU B 2 177 ? 152.070 183.673 151.151 1.00 74.08  ? 199 GLU B CA  1 
ATOM   1979 C C   . GLU B 2 177 ? 153.198 184.592 150.710 1.00 74.08  ? 199 GLU B C   1 
ATOM   1980 O O   . GLU B 2 177 ? 154.097 184.902 151.499 1.00 74.08  ? 199 GLU B O   1 
ATOM   1981 C CB  . GLU B 2 177 ? 151.279 184.299 152.303 1.00 74.08  ? 199 GLU B CB  1 
ATOM   1982 C CG  . GLU B 2 177 ? 151.911 184.117 153.673 1.00 74.08  ? 199 GLU B CG  1 
ATOM   1983 C CD  . GLU B 2 177 ? 151.060 184.684 154.790 1.00 74.08  ? 199 GLU B CD  1 
ATOM   1984 O OE1 . GLU B 2 177 ? 149.959 185.196 154.499 1.00 74.08  ? 199 GLU B OE1 1 
ATOM   1985 O OE2 . GLU B 2 177 ? 151.492 184.618 155.960 1.00 74.08  ? 199 GLU B OE2 1 
ATOM   1986 N N   . ALA B 2 178 ? 153.152 185.023 149.453 1.00 86.85  ? 200 ALA B N   1 
ATOM   1987 C CA  . ALA B 2 178 ? 154.160 185.908 148.887 1.00 86.85  ? 200 ALA B CA  1 
ATOM   1988 C C   . ALA B 2 178 ? 153.652 187.343 148.920 1.00 86.85  ? 200 ALA B C   1 
ATOM   1989 O O   . ALA B 2 178 ? 152.522 187.614 148.502 1.00 86.85  ? 200 ALA B O   1 
ATOM   1990 C CB  . ALA B 2 178 ? 154.502 185.501 147.453 1.00 86.85  ? 200 ALA B CB  1 
ATOM   1991 N N   . GLU B 2 179 ? 154.488 188.255 149.412 1.00 96.07  ? 201 GLU B N   1 
ATOM   1992 C CA  . GLU B 2 179 ? 154.105 189.650 149.567 1.00 96.07  ? 201 GLU B CA  1 
ATOM   1993 C C   . GLU B 2 179 ? 155.260 190.549 149.152 1.00 96.07  ? 201 GLU B C   1 
ATOM   1994 O O   . GLU B 2 179 ? 156.432 190.182 149.276 1.00 96.07  ? 201 GLU B O   1 
ATOM   1995 C CB  . GLU B 2 179 ? 153.692 189.963 151.011 1.00 96.07  ? 201 GLU B CB  1 
ATOM   1996 C CG  . GLU B 2 179 ? 154.769 189.661 152.041 1.00 96.07  ? 201 GLU B CG  1 
ATOM   1997 C CD  . GLU B 2 179 ? 154.260 189.756 153.465 1.00 96.07  ? 201 GLU B CD  1 
ATOM   1998 O OE1 . GLU B 2 179 ? 153.053 190.017 153.650 1.00 96.07  ? 201 GLU B OE1 1 
ATOM   1999 O OE2 . GLU B 2 179 ? 155.068 189.569 154.399 1.00 96.07  ? 201 GLU B OE2 1 
ATOM   2000 N N   . ASN B 2 180 ? 154.913 191.729 148.652 1.00 102.64 ? 202 ASN B N   1 
ATOM   2001 C CA  . ASN B 2 180 ? 155.895 192.738 148.271 1.00 102.64 ? 202 ASN B CA  1 
ATOM   2002 C C   . ASN B 2 180 ? 155.263 194.107 148.500 1.00 102.64 ? 202 ASN B C   1 
ATOM   2003 O O   . ASN B 2 180 ? 154.215 194.235 149.144 1.00 102.64 ? 202 ASN B O   1 
ATOM   2004 C CB  . ASN B 2 180 ? 156.358 192.530 146.822 1.00 102.64 ? 202 ASN B CB  1 
ATOM   2005 C CG  . ASN B 2 180 ? 155.368 193.071 145.812 1.00 102.64 ? 202 ASN B CG  1 
ATOM   2006 O OD1 . ASN B 2 180 ? 154.187 192.727 145.836 1.00 102.64 ? 202 ASN B OD1 1 
ATOM   2007 N ND2 . ASN B 2 180 ? 155.844 193.935 144.924 1.00 102.64 ? 202 ASN B ND2 1 
ATOM   2008 N N   . ALA B 2 181 ? 155.901 195.152 147.969 1.00 100.91 ? 203 ALA B N   1 
ATOM   2009 C CA  . ALA B 2 181 ? 155.378 196.504 148.122 1.00 100.91 ? 203 ALA B CA  1 
ATOM   2010 C C   . ALA B 2 181 ? 154.134 196.752 147.278 1.00 100.91 ? 203 ALA B C   1 
ATOM   2011 O O   . ALA B 2 181 ? 153.453 197.761 147.488 1.00 100.91 ? 203 ALA B O   1 
ATOM   2012 C CB  . ALA B 2 181 ? 156.456 197.528 147.766 1.00 100.91 ? 203 ALA B CB  1 
ATOM   2013 N N   . LEU B 2 182 ? 153.820 195.863 146.335 1.00 98.60  ? 204 LEU B N   1 
ATOM   2014 C CA  . LEU B 2 182 ? 152.691 196.062 145.437 1.00 98.60  ? 204 LEU B CA  1 
ATOM   2015 C C   . LEU B 2 182 ? 151.499 195.164 145.743 1.00 98.60  ? 204 LEU B C   1 
ATOM   2016 O O   . LEU B 2 182 ? 150.450 195.323 145.110 1.00 98.60  ? 204 LEU B O   1 
ATOM   2017 C CB  . LEU B 2 182 ? 153.127 195.843 143.983 1.00 98.60  ? 204 LEU B CB  1 
ATOM   2018 C CG  . LEU B 2 182 ? 154.136 196.850 143.429 1.00 98.60  ? 204 LEU B CG  1 
ATOM   2019 C CD1 . LEU B 2 182 ? 154.475 196.530 141.983 1.00 98.60  ? 204 LEU B CD1 1 
ATOM   2020 C CD2 . LEU B 2 182 ? 153.602 198.266 143.555 1.00 98.60  ? 204 LEU B CD2 1 
ATOM   2021 N N   . GLY B 2 183 ? 151.623 194.239 146.678 1.00 96.13  ? 205 GLY B N   1 
ATOM   2022 C CA  . GLY B 2 183 ? 150.509 193.385 147.038 1.00 96.13  ? 205 GLY B CA  1 
ATOM   2023 C C   . GLY B 2 183 ? 150.995 192.061 147.589 1.00 96.13  ? 205 GLY B C   1 
ATOM   2024 O O   . GLY B 2 183 ? 152.190 191.792 147.674 1.00 96.13  ? 205 GLY B O   1 
ATOM   2025 N N   . LYS B 2 184 ? 150.025 191.231 147.966 1.00 88.11  ? 206 LYS B N   1 
ATOM   2026 C CA  . LYS B 2 184 ? 150.288 189.913 148.520 1.00 88.11  ? 206 LYS B CA  1 
ATOM   2027 C C   . LYS B 2 184 ? 149.404 188.883 147.830 1.00 88.11  ? 206 LYS B C   1 
ATOM   2028 O O   . LYS B 2 184 ? 148.322 189.203 147.332 1.00 88.11  ? 206 LYS B O   1 
ATOM   2029 C CB  . LYS B 2 184 ? 150.043 189.875 150.036 1.00 88.11  ? 206 LYS B CB  1 
ATOM   2030 C CG  . LYS B 2 184 ? 148.587 190.060 150.435 1.00 88.11  ? 206 LYS B CG  1 
ATOM   2031 C CD  . LYS B 2 184 ? 148.368 189.736 151.904 1.00 88.11  ? 206 LYS B CD  1 
ATOM   2032 C CE  . LYS B 2 184 ? 149.238 190.602 152.799 1.00 88.11  ? 206 LYS B CE  1 
ATOM   2033 N NZ  . LYS B 2 184 ? 149.033 190.291 154.240 1.00 88.11  ? 206 LYS B NZ  1 
ATOM   2034 N N   . VAL B 2 185 ? 149.880 187.642 147.807 1.00 80.89  ? 207 VAL B N   1 
ATOM   2035 C CA  . VAL B 2 185 ? 149.140 186.542 147.200 1.00 80.89  ? 207 VAL B CA  1 
ATOM   2036 C C   . VAL B 2 185 ? 149.607 185.247 147.850 1.00 80.89  ? 207 VAL B C   1 
ATOM   2037 O O   . VAL B 2 185 ? 150.791 185.082 148.159 1.00 80.89  ? 207 VAL B O   1 
ATOM   2038 C CB  . VAL B 2 185 ? 149.322 186.524 145.663 1.00 80.89  ? 207 VAL B CB  1 
ATOM   2039 C CG1 . VAL B 2 185 ? 150.790 186.366 145.294 1.00 80.89  ? 207 VAL B CG1 1 
ATOM   2040 C CG2 . VAL B 2 185 ? 148.477 185.428 145.033 1.00 80.89  ? 207 VAL B CG2 1 
ATOM   2041 N N   . THR B 2 186 ? 148.665 184.333 148.066 1.00 72.83  ? 208 THR B N   1 
ATOM   2042 C CA  . THR B 2 186 ? 148.930 183.070 148.736 1.00 72.83  ? 208 THR B CA  1 
ATOM   2043 C C   . THR B 2 186 ? 148.862 181.917 147.744 1.00 72.83  ? 208 THR B C   1 
ATOM   2044 O O   . THR B 2 186 ? 148.065 181.931 146.801 1.00 72.83  ? 208 THR B O   1 
ATOM   2045 C CB  . THR B 2 186 ? 147.931 182.829 149.872 1.00 72.83  ? 208 THR B CB  1 
ATOM   2046 O OG1 . THR B 2 186 ? 146.622 182.635 149.324 1.00 72.83  ? 208 THR B OG1 1 
ATOM   2047 C CG2 . THR B 2 186 ? 147.904 184.020 150.816 1.00 72.83  ? 208 THR B CG2 1 
ATOM   2048 N N   . SER B 2 187 ? 149.705 180.914 147.969 1.00 69.20  ? 209 SER B N   1 
ATOM   2049 C CA  . SER B 2 187 ? 149.751 179.737 147.114 1.00 69.20  ? 209 SER B CA  1 
ATOM   2050 C C   . SER B 2 187 ? 148.621 178.784 147.495 1.00 69.20  ? 209 SER B C   1 
ATOM   2051 O O   . SER B 2 187 ? 147.710 179.128 148.252 1.00 69.20  ? 209 SER B O   1 
ATOM   2052 C CB  . SER B 2 187 ? 151.117 179.065 147.212 1.00 69.20  ? 209 SER B CB  1 
ATOM   2053 O OG  . SER B 2 187 ? 152.158 180.011 147.066 1.00 69.20  ? 209 SER B OG  1 
ATOM   2054 N N   . ASP B 2 188 ? 148.667 177.565 146.964 1.00 66.03  ? 210 ASP B N   1 
ATOM   2055 C CA  . ASP B 2 188 ? 147.659 176.572 147.292 1.00 66.03  ? 210 ASP B CA  1 
ATOM   2056 C C   . ASP B 2 188 ? 147.892 176.012 148.693 1.00 66.03  ? 210 ASP B C   1 
ATOM   2057 O O   . ASP B 2 188 ? 148.980 176.120 149.266 1.00 66.03  ? 210 ASP B O   1 
ATOM   2058 C CB  . ASP B 2 188 ? 147.664 175.443 146.263 1.00 66.03  ? 210 ASP B CB  1 
ATOM   2059 C CG  . ASP B 2 188 ? 147.132 175.884 144.915 1.00 66.03  ? 210 ASP B CG  1 
ATOM   2060 O OD1 . ASP B 2 188 ? 146.198 176.712 144.887 1.00 66.03  ? 210 ASP B OD1 1 
ATOM   2061 O OD2 . ASP B 2 188 ? 147.648 175.404 143.885 1.00 66.03  ? 210 ASP B OD2 1 
ATOM   2062 N N   . HIS B 2 189 ? 146.845 175.406 149.244 1.00 55.48  ? 211 HIS B N   1 
ATOM   2063 C CA  . HIS B 2 189 ? 146.861 174.865 150.595 1.00 55.48  ? 211 HIS B CA  1 
ATOM   2064 C C   . HIS B 2 189 ? 146.803 173.346 150.537 1.00 55.48  ? 211 HIS B C   1 
ATOM   2065 O O   . HIS B 2 189 ? 145.895 172.779 149.920 1.00 55.48  ? 211 HIS B O   1 
ATOM   2066 C CB  . HIS B 2 189 ? 145.689 175.413 151.411 1.00 55.48  ? 211 HIS B CB  1 
ATOM   2067 C CG  . HIS B 2 189 ? 145.479 176.886 151.250 1.00 55.48  ? 211 HIS B CG  1 
ATOM   2068 N ND1 . HIS B 2 189 ? 146.067 177.817 152.078 1.00 55.48  ? 211 HIS B ND1 1 
ATOM   2069 C CD2 . HIS B 2 189 ? 144.749 177.590 150.353 1.00 55.48  ? 211 HIS B CD2 1 
ATOM   2070 C CE1 . HIS B 2 189 ? 145.708 179.031 151.699 1.00 55.48  ? 211 HIS B CE1 1 
ATOM   2071 N NE2 . HIS B 2 189 ? 144.907 178.920 150.655 1.00 55.48  ? 211 HIS B NE2 1 
ATOM   2072 N N   . ILE B 2 190 ? 147.770 172.693 151.177 1.00 50.44  ? 212 ILE B N   1 
ATOM   2073 C CA  . ILE B 2 190 ? 147.842 171.239 151.218 1.00 50.44  ? 212 ILE B CA  1 
ATOM   2074 C C   . ILE B 2 190 ? 147.954 170.790 152.667 1.00 50.44  ? 212 ILE B C   1 
ATOM   2075 O O   . ILE B 2 190 ? 148.504 171.496 153.518 1.00 50.44  ? 212 ILE B O   1 
ATOM   2076 C CB  . ILE B 2 190 ? 149.025 170.691 150.391 1.00 50.44  ? 212 ILE B CB  1 
ATOM   2077 C CG1 . ILE B 2 190 ? 150.355 171.180 150.969 1.00 50.44  ? 212 ILE B CG1 1 
ATOM   2078 C CG2 . ILE B 2 190 ? 148.890 171.092 148.932 1.00 50.44  ? 212 ILE B CG2 1 
ATOM   2079 C CD1 . ILE B 2 190 ? 151.571 170.521 150.357 1.00 50.44  ? 212 ILE B CD1 1 
ATOM   2080 N N   . ASN B 2 191 ? 147.419 169.604 152.944 1.00 44.31  ? 213 ASN B N   1 
ATOM   2081 C CA  . ASN B 2 191 ? 147.527 168.977 154.252 1.00 44.31  ? 213 ASN B CA  1 
ATOM   2082 C C   . ASN B 2 191 ? 148.097 167.579 154.084 1.00 44.31  ? 213 ASN B C   1 
ATOM   2083 O O   . ASN B 2 191 ? 147.691 166.838 153.184 1.00 44.31  ? 213 ASN B O   1 
ATOM   2084 C CB  . ASN B 2 191 ? 146.170 168.920 154.966 1.00 44.31  ? 213 ASN B CB  1 
ATOM   2085 C CG  . ASN B 2 191 ? 145.043 168.509 154.044 1.00 44.31  ? 213 ASN B CG  1 
ATOM   2086 O OD1 . ASN B 2 191 ? 145.258 168.239 152.864 1.00 44.31  ? 213 ASN B OD1 1 
ATOM   2087 N ND2 . ASN B 2 191 ? 143.829 168.462 154.579 1.00 44.31  ? 213 ASN B ND2 1 
ATOM   2088 N N   . PHE B 2 192 ? 149.041 167.221 154.951 1.00 43.78  ? 214 PHE B N   1 
ATOM   2089 C CA  . PHE B 2 192 ? 149.749 165.959 154.818 1.00 43.78  ? 214 PHE B CA  1 
ATOM   2090 C C   . PHE B 2 192 ? 150.214 165.485 156.186 1.00 43.78  ? 214 PHE B C   1 
ATOM   2091 O O   . PHE B 2 192 ? 150.620 166.285 157.033 1.00 43.78  ? 214 PHE B O   1 
ATOM   2092 C CB  . PHE B 2 192 ? 150.948 166.090 153.873 1.00 43.78  ? 214 PHE B CB  1 
ATOM   2093 C CG  . PHE B 2 192 ? 151.963 167.101 154.321 1.00 43.78  ? 214 PHE B CG  1 
ATOM   2094 C CD1 . PHE B 2 192 ? 151.796 168.444 154.033 1.00 43.78  ? 214 PHE B CD1 1 
ATOM   2095 C CD2 . PHE B 2 192 ? 153.087 166.709 155.026 1.00 43.78  ? 214 PHE B CD2 1 
ATOM   2096 C CE1 . PHE B 2 192 ? 152.728 169.376 154.443 1.00 43.78  ? 214 PHE B CE1 1 
ATOM   2097 C CE2 . PHE B 2 192 ? 154.022 167.636 155.438 1.00 43.78  ? 214 PHE B CE2 1 
ATOM   2098 C CZ  . PHE B 2 192 ? 153.842 168.971 155.145 1.00 43.78  ? 214 PHE B CZ  1 
ATOM   2099 N N   . ASP B 2 193 ? 150.156 164.175 156.386 1.00 42.18  ? 215 ASP B N   1 
ATOM   2100 C CA  . ASP B 2 193 ? 150.648 163.572 157.616 1.00 42.18  ? 215 ASP B CA  1 
ATOM   2101 C C   . ASP B 2 193 ? 152.172 163.588 157.612 1.00 42.18  ? 215 ASP B C   1 
ATOM   2102 O O   . ASP B 2 193 ? 152.781 163.033 156.691 1.00 42.18  ? 215 ASP B O   1 
ATOM   2103 C CB  . ASP B 2 193 ? 150.131 162.144 157.742 1.00 42.18  ? 215 ASP B CB  1 
ATOM   2104 C CG  . ASP B 2 193 ? 150.148 161.637 159.169 1.00 42.18  ? 215 ASP B CG  1 
ATOM   2105 O OD1 . ASP B 2 193 ? 150.736 162.311 160.037 1.00 42.18  ? 215 ASP B OD1 1 
ATOM   2106 O OD2 . ASP B 2 193 ? 149.571 160.559 159.423 1.00 42.18  ? 215 ASP B OD2 1 
ATOM   2107 N N   . PRO B 2 194 ? 152.822 164.213 158.597 1.00 42.25  ? 216 PRO B N   1 
ATOM   2108 C CA  . PRO B 2 194 ? 154.294 164.283 158.579 1.00 42.25  ? 216 PRO B CA  1 
ATOM   2109 C C   . PRO B 2 194 ? 154.981 162.929 158.615 1.00 42.25  ? 216 PRO B C   1 
ATOM   2110 O O   . PRO B 2 194 ? 156.189 162.863 158.354 1.00 42.25  ? 216 PRO B O   1 
ATOM   2111 C CB  . PRO B 2 194 ? 154.621 165.105 159.832 1.00 42.25  ? 216 PRO B CB  1 
ATOM   2112 C CG  . PRO B 2 194 ? 153.393 165.902 160.091 1.00 42.25  ? 216 PRO B CG  1 
ATOM   2113 C CD  . PRO B 2 194 ? 152.245 165.034 159.673 1.00 42.25  ? 216 PRO B CD  1 
ATOM   2114 N N   . VAL B 2 195 ? 154.263 161.849 158.930 1.00 43.10  ? 217 VAL B N   1 
ATOM   2115 C CA  . VAL B 2 195 ? 154.876 160.527 158.925 1.00 43.10  ? 217 VAL B CA  1 
ATOM   2116 C C   . VAL B 2 195 ? 155.068 160.007 157.506 1.00 43.10  ? 217 VAL B C   1 
ATOM   2117 O O   . VAL B 2 195 ? 155.836 159.062 157.293 1.00 43.10  ? 217 VAL B O   1 
ATOM   2118 C CB  . VAL B 2 195 ? 154.038 159.547 159.768 1.00 43.10  ? 217 VAL B CB  1 
ATOM   2119 C CG1 . VAL B 2 195 ? 152.784 159.134 159.021 1.00 43.10  ? 217 VAL B CG1 1 
ATOM   2120 C CG2 . VAL B 2 195 ? 154.862 158.331 160.165 1.00 43.10  ? 217 VAL B CG2 1 
ATOM   2121 N N   . TYR B 2 196 ? 154.400 160.608 156.522 1.00 44.18  ? 218 TYR B N   1 
ATOM   2122 C CA  . TYR B 2 196 ? 154.527 160.195 155.131 1.00 44.18  ? 218 TYR B CA  1 
ATOM   2123 C C   . TYR B 2 196 ? 155.686 160.866 154.407 1.00 44.18  ? 218 TYR B C   1 
ATOM   2124 O O   . TYR B 2 196 ? 155.935 160.543 153.242 1.00 44.18  ? 218 TYR B O   1 
ATOM   2125 C CB  . TYR B 2 196 ? 153.227 160.484 154.374 1.00 44.18  ? 218 TYR B CB  1 
ATOM   2126 C CG  . TYR B 2 196 ? 152.177 159.413 154.532 1.00 44.18  ? 218 TYR B CG  1 
ATOM   2127 C CD1 . TYR B 2 196 ? 151.846 158.578 153.475 1.00 44.18  ? 218 TYR B CD1 1 
ATOM   2128 C CD2 . TYR B 2 196 ? 151.516 159.235 155.737 1.00 44.18  ? 218 TYR B CD2 1 
ATOM   2129 C CE1 . TYR B 2 196 ? 150.885 157.597 153.615 1.00 44.18  ? 218 TYR B CE1 1 
ATOM   2130 C CE2 . TYR B 2 196 ? 150.555 158.256 155.887 1.00 44.18  ? 218 TYR B CE2 1 
ATOM   2131 C CZ  . TYR B 2 196 ? 150.243 157.440 154.823 1.00 44.18  ? 218 TYR B CZ  1 
ATOM   2132 O OH  . TYR B 2 196 ? 149.285 156.464 154.968 1.00 44.18  ? 218 TYR B OH  1 
ATOM   2133 N N   . LYS B 2 197 ? 156.394 161.789 155.058 1.00 46.22  ? 219 LYS B N   1 
ATOM   2134 C CA  . LYS B 2 197 ? 157.500 162.510 154.441 1.00 46.22  ? 219 LYS B CA  1 
ATOM   2135 C C   . LYS B 2 197 ? 158.835 162.211 155.115 1.00 46.22  ? 219 LYS B C   1 
ATOM   2136 O O   . LYS B 2 197 ? 159.794 162.971 154.947 1.00 46.22  ? 219 LYS B O   1 
ATOM   2137 C CB  . LYS B 2 197 ? 157.227 164.013 154.462 1.00 46.22  ? 219 LYS B CB  1 
ATOM   2138 C CG  . LYS B 2 197 ? 155.839 164.407 153.985 1.00 46.22  ? 219 LYS B CG  1 
ATOM   2139 C CD  . LYS B 2 197 ? 155.749 164.408 152.469 1.00 46.22  ? 219 LYS B CD  1 
ATOM   2140 C CE  . LYS B 2 197 ? 154.438 165.017 151.998 1.00 46.22  ? 219 LYS B CE  1 
ATOM   2141 N NZ  . LYS B 2 197 ? 154.386 165.160 150.518 1.00 46.22  ? 219 LYS B NZ  1 
ATOM   2142 N N   . VAL B 2 198 ? 158.919 161.122 155.870 1.00 48.63  ? 220 VAL B N   1 
ATOM   2143 C CA  . VAL B 2 198 ? 160.113 160.818 156.649 1.00 48.63  ? 220 VAL B CA  1 
ATOM   2144 C C   . VAL B 2 198 ? 161.187 160.236 155.742 1.00 48.63  ? 220 VAL B C   1 
ATOM   2145 O O   . VAL B 2 198 ? 160.909 159.399 154.875 1.00 48.63  ? 220 VAL B O   1 
ATOM   2146 C CB  . VAL B 2 198 ? 159.772 159.856 157.800 1.00 48.63  ? 220 VAL B CB  1 
ATOM   2147 C CG1 . VAL B 2 198 ? 160.978 159.654 158.701 1.00 48.63  ? 220 VAL B CG1 1 
ATOM   2148 C CG2 . VAL B 2 198 ? 158.593 160.385 158.596 1.00 48.63  ? 220 VAL B CG2 1 
ATOM   2149 N N   . LYS B 2 199 ? 162.429 160.683 155.941 1.00 58.73  ? 221 LYS B N   1 
ATOM   2150 C CA  . LYS B 2 199 ? 163.599 160.173 155.227 1.00 58.73  ? 221 LYS B CA  1 
ATOM   2151 C C   . LYS B 2 199 ? 164.522 159.519 156.247 1.00 58.73  ? 221 LYS B C   1 
ATOM   2152 O O   . LYS B 2 199 ? 165.328 160.202 156.897 1.00 58.73  ? 221 LYS B O   1 
ATOM   2153 C CB  . LYS B 2 199 ? 164.315 161.288 154.470 1.00 58.73  ? 221 LYS B CB  1 
ATOM   2154 C CG  . LYS B 2 199 ? 165.550 160.830 153.711 1.00 58.73  ? 221 LYS B CG  1 
ATOM   2155 C CD  . LYS B 2 199 ? 166.326 162.013 153.158 1.00 58.73  ? 221 LYS B CD  1 
ATOM   2156 C CE  . LYS B 2 199 ? 167.548 161.558 152.377 1.00 58.73  ? 221 LYS B CE  1 
ATOM   2157 N NZ  . LYS B 2 199 ? 167.176 160.708 151.214 1.00 58.73  ? 221 LYS B NZ  1 
ATOM   2158 N N   . PRO B 2 200 ? 164.441 158.202 156.420 1.00 63.22  ? 222 PRO B N   1 
ATOM   2159 C CA  . PRO B 2 200 ? 165.214 157.542 157.479 1.00 63.22  ? 222 PRO B CA  1 
ATOM   2160 C C   . PRO B 2 200 ? 166.701 157.506 157.158 1.00 63.22  ? 222 PRO B C   1 
ATOM   2161 O O   . PRO B 2 200 ? 167.161 157.952 156.106 1.00 63.22  ? 222 PRO B O   1 
ATOM   2162 C CB  . PRO B 2 200 ? 164.617 156.134 157.524 1.00 63.22  ? 222 PRO B CB  1 
ATOM   2163 C CG  . PRO B 2 200 ? 164.098 155.912 156.145 1.00 63.22  ? 222 PRO B CG  1 
ATOM   2164 C CD  . PRO B 2 200 ? 163.615 157.250 155.659 1.00 63.22  ? 222 PRO B CD  1 
ATOM   2165 N N   . ASN B 2 201 ? 167.458 156.959 158.107 1.00 69.50  ? 223 ASN B N   1 
ATOM   2166 C CA  . ASN B 2 201 ? 168.899 156.797 158.008 1.00 69.50  ? 223 ASN B CA  1 
ATOM   2167 C C   . ASN B 2 201 ? 169.247 155.415 157.472 1.00 69.50  ? 223 ASN B C   1 
ATOM   2168 O O   . ASN B 2 201 ? 168.458 154.473 157.592 1.00 69.50  ? 223 ASN B O   1 
ATOM   2169 C CB  . ASN B 2 201 ? 169.542 157.007 159.378 1.00 69.50  ? 223 ASN B CB  1 
ATOM   2170 C CG  . ASN B 2 201 ? 169.562 158.463 159.794 1.00 69.50  ? 223 ASN B CG  1 
ATOM   2171 O OD1 . ASN B 2 201 ? 169.601 159.360 158.952 1.00 69.50  ? 223 ASN B OD1 1 
ATOM   2172 N ND2 . ASN B 2 201 ? 169.541 158.707 161.098 1.00 69.50  ? 223 ASN B ND2 1 
ATOM   2173 N N   . PRO B 2 202 ? 170.422 155.258 156.867 1.00 68.27  ? 224 PRO B N   1 
ATOM   2174 C CA  . PRO B 2 202 ? 170.805 153.951 156.324 1.00 68.27  ? 224 PRO B CA  1 
ATOM   2175 C C   . PRO B 2 202 ? 171.161 152.983 157.436 1.00 68.27  ? 224 PRO B C   1 
ATOM   2176 O O   . PRO B 2 202 ? 171.709 153.388 158.472 1.00 68.27  ? 224 PRO B O   1 
ATOM   2177 C CB  . PRO B 2 202 ? 172.028 154.277 155.457 1.00 68.27  ? 224 PRO B CB  1 
ATOM   2178 C CG  . PRO B 2 202 ? 172.607 155.493 156.084 1.00 68.27  ? 224 PRO B CG  1 
ATOM   2179 C CD  . PRO B 2 202 ? 171.436 156.289 156.584 1.00 68.27  ? 224 PRO B CD  1 
ATOM   2180 N N   . PRO B 2 203 ? 170.857 151.696 157.264 1.00 70.13  ? 225 PRO B N   1 
ATOM   2181 C CA  . PRO B 2 203 ? 171.247 150.699 158.273 1.00 70.13  ? 225 PRO B CA  1 
ATOM   2182 C C   . PRO B 2 203 ? 172.761 150.609 158.392 1.00 70.13  ? 225 PRO B C   1 
ATOM   2183 O O   . PRO B 2 203 ? 173.464 150.330 157.418 1.00 70.13  ? 225 PRO B O   1 
ATOM   2184 C CB  . PRO B 2 203 ? 170.638 149.398 157.738 1.00 70.13  ? 225 PRO B CB  1 
ATOM   2185 C CG  . PRO B 2 203 ? 169.563 149.831 156.796 1.00 70.13  ? 225 PRO B CG  1 
ATOM   2186 C CD  . PRO B 2 203 ? 170.057 151.103 156.182 1.00 70.13  ? 225 PRO B CD  1 
ATOM   2187 N N   . HIS B 2 204 ? 173.260 150.850 159.601 1.00 74.99  ? 226 HIS B N   1 
ATOM   2188 C CA  . HIS B 2 204 ? 174.690 150.873 159.854 1.00 74.99  ? 226 HIS B CA  1 
ATOM   2189 C C   . HIS B 2 204 ? 175.167 149.515 160.366 1.00 74.99  ? 226 HIS B C   1 
ATOM   2190 O O   . HIS B 2 204 ? 174.382 148.587 160.578 1.00 74.99  ? 226 HIS B O   1 
ATOM   2191 C CB  . HIS B 2 204 ? 175.034 151.984 160.845 1.00 74.99  ? 226 HIS B CB  1 
ATOM   2192 C CG  . HIS B 2 204 ? 174.354 151.841 162.172 1.00 74.99  ? 226 HIS B CG  1 
ATOM   2193 N ND1 . HIS B 2 204 ? 172.998 152.022 162.338 1.00 74.99  ? 226 HIS B ND1 1 
ATOM   2194 C CD2 . HIS B 2 204 ? 174.845 151.535 163.396 1.00 74.99  ? 226 HIS B CD2 1 
ATOM   2195 C CE1 . HIS B 2 204 ? 172.682 151.833 163.606 1.00 74.99  ? 226 HIS B CE1 1 
ATOM   2196 N NE2 . HIS B 2 204 ? 173.785 151.536 164.270 1.00 74.99  ? 226 HIS B NE2 1 
ATOM   2197 N N   . ASN B 2 205 ? 176.483 149.405 160.567 1.00 81.15  ? 227 ASN B N   1 
ATOM   2198 C CA  . ASN B 2 205 ? 177.118 148.194 161.091 1.00 81.15  ? 227 ASN B CA  1 
ATOM   2199 C C   . ASN B 2 205 ? 176.821 146.982 160.208 1.00 81.15  ? 227 ASN B C   1 
ATOM   2200 O O   . ASN B 2 205 ? 176.340 145.946 160.672 1.00 81.15  ? 227 ASN B O   1 
ATOM   2201 C CB  . ASN B 2 205 ? 176.700 147.934 162.540 1.00 81.15  ? 227 ASN B CB  1 
ATOM   2202 C CG  . ASN B 2 205 ? 177.713 148.455 163.538 1.00 81.15  ? 227 ASN B CG  1 
ATOM   2203 O OD1 . ASN B 2 205 ? 178.831 148.819 163.172 1.00 81.15  ? 227 ASN B OD1 1 
ATOM   2204 N ND2 . ASN B 2 205 ? 177.328 148.492 164.806 1.00 81.15  ? 227 ASN B ND2 1 
ATOM   2205 N N   . LEU B 2 206 ? 177.114 147.122 158.920 1.00 81.16  ? 228 LEU B N   1 
ATOM   2206 C CA  . LEU B 2 206 ? 176.956 146.019 157.985 1.00 81.16  ? 228 LEU B CA  1 
ATOM   2207 C C   . LEU B 2 206 ? 178.141 145.069 158.092 1.00 81.16  ? 228 LEU B C   1 
ATOM   2208 O O   . LEU B 2 206 ? 179.294 145.499 158.185 1.00 81.16  ? 228 LEU B O   1 
ATOM   2209 C CB  . LEU B 2 206 ? 176.828 146.545 156.555 1.00 81.16  ? 228 LEU B CB  1 
ATOM   2210 C CG  . LEU B 2 206 ? 176.409 145.531 155.491 1.00 81.16  ? 228 LEU B CG  1 
ATOM   2211 C CD1 . LEU B 2 206 ? 174.994 145.045 155.750 1.00 81.16  ? 228 LEU B CD1 1 
ATOM   2212 C CD2 . LEU B 2 206 ? 176.524 146.136 154.103 1.00 81.16  ? 228 LEU B CD2 1 
ATOM   2213 N N   . SER B 2 207 ? 177.851 143.769 158.083 1.00 82.21  ? 229 SER B N   1 
ATOM   2214 C CA  . SER B 2 207 ? 178.890 142.759 158.203 1.00 82.21  ? 229 SER B CA  1 
ATOM   2215 C C   . SER B 2 207 ? 178.495 141.532 157.395 1.00 82.21  ? 229 SER B C   1 
ATOM   2216 O O   . SER B 2 207 ? 177.312 141.199 157.283 1.00 82.21  ? 229 SER B O   1 
ATOM   2217 C CB  . SER B 2 207 ? 179.135 142.376 159.666 1.00 82.21  ? 229 SER B CB  1 
ATOM   2218 O OG  . SER B 2 207 ? 177.910 142.220 160.361 1.00 82.21  ? 229 SER B OG  1 
ATOM   2219 N N   . VAL B 2 208 ? 179.499 140.862 156.837 1.00 85.98  ? 230 VAL B N   1 
ATOM   2220 C CA  . VAL B 2 208 ? 179.305 139.668 156.023 1.00 85.98  ? 230 VAL B CA  1 
ATOM   2221 C C   . VAL B 2 208 ? 180.041 138.517 156.692 1.00 85.98  ? 230 VAL B C   1 
ATOM   2222 O O   . VAL B 2 208 ? 181.253 138.602 156.929 1.00 85.98  ? 230 VAL B O   1 
ATOM   2223 C CB  . VAL B 2 208 ? 179.802 139.869 154.583 1.00 85.98  ? 230 VAL B CB  1 
ATOM   2224 C CG1 . VAL B 2 208 ? 179.653 138.581 153.788 1.00 85.98  ? 230 VAL B CG1 1 
ATOM   2225 C CG2 . VAL B 2 208 ? 179.051 141.009 153.917 1.00 85.98  ? 230 VAL B CG2 1 
ATOM   2226 N N   . ILE B 2 209 ? 179.313 137.446 156.995 1.00 91.94  ? 231 ILE B N   1 
ATOM   2227 C CA  . ILE B 2 209 ? 179.876 136.252 157.612 1.00 91.94  ? 231 ILE B CA  1 
ATOM   2228 C C   . ILE B 2 209 ? 179.519 135.051 156.747 1.00 91.94  ? 231 ILE B C   1 
ATOM   2229 O O   . ILE B 2 209 ? 178.368 134.910 156.318 1.00 91.94  ? 231 ILE B O   1 
ATOM   2230 C CB  . ILE B 2 209 ? 179.369 136.060 159.056 1.00 91.94  ? 231 ILE B CB  1 
ATOM   2231 C CG1 . ILE B 2 209 ? 179.765 134.681 159.590 1.00 91.94  ? 231 ILE B CG1 1 
ATOM   2232 C CG2 . ILE B 2 209 ? 177.863 136.273 159.134 1.00 91.94  ? 231 ILE B CG2 1 
ATOM   2233 C CD1 . ILE B 2 209 ? 179.398 134.461 161.040 1.00 91.94  ? 231 ILE B CD1 1 
ATOM   2234 N N   . ASN B 2 210 ? 180.504 134.196 156.484 1.00 95.23  ? 232 ASN B N   1 
ATOM   2235 C CA  . ASN B 2 210 ? 180.299 133.020 155.655 1.00 95.23  ? 232 ASN B CA  1 
ATOM   2236 C C   . ASN B 2 210 ? 180.032 131.795 156.527 1.00 95.23  ? 232 ASN B C   1 
ATOM   2237 O O   . ASN B 2 210 ? 179.966 131.872 157.756 1.00 95.23  ? 232 ASN B O   1 
ATOM   2238 C CB  . ASN B 2 210 ? 181.504 132.793 154.744 1.00 95.23  ? 232 ASN B CB  1 
ATOM   2239 C CG  . ASN B 2 210 ? 182.822 132.895 155.485 1.00 95.23  ? 232 ASN B CG  1 
ATOM   2240 O OD1 . ASN B 2 210 ? 182.859 132.889 156.715 1.00 95.23  ? 232 ASN B OD1 1 
ATOM   2241 N ND2 . ASN B 2 210 ? 183.915 132.991 154.737 1.00 95.23  ? 232 ASN B ND2 1 
ATOM   2242 N N   . SER B 2 211 ? 179.873 130.645 155.877 1.00 100.08 ? 233 SER B N   1 
ATOM   2243 C CA  . SER B 2 211 ? 179.649 129.379 156.557 1.00 100.08 ? 233 SER B CA  1 
ATOM   2244 C C   . SER B 2 211 ? 180.603 128.335 155.998 1.00 100.08 ? 233 SER B C   1 
ATOM   2245 O O   . SER B 2 211 ? 180.818 128.267 154.785 1.00 100.08 ? 233 SER B O   1 
ATOM   2246 C CB  . SER B 2 211 ? 178.202 128.902 156.395 1.00 100.08 ? 233 SER B CB  1 
ATOM   2247 O OG  . SER B 2 211 ? 177.930 128.567 155.046 1.00 100.08 ? 233 SER B OG  1 
ATOM   2248 N N   . GLU B 2 212 ? 181.172 127.522 156.887 1.00 103.82 ? 234 GLU B N   1 
ATOM   2249 C CA  . GLU B 2 212 ? 182.117 126.485 156.501 1.00 103.82 ? 234 GLU B CA  1 
ATOM   2250 C C   . GLU B 2 212 ? 181.432 125.178 156.113 1.00 103.82 ? 234 GLU B C   1 
ATOM   2251 O O   . GLU B 2 212 ? 182.098 124.140 156.033 1.00 103.82 ? 234 GLU B O   1 
ATOM   2252 C CB  . GLU B 2 212 ? 183.120 126.241 157.630 1.00 103.82 ? 234 GLU B CB  1 
ATOM   2253 C CG  . GLU B 2 212 ? 183.664 127.516 158.254 1.00 103.82 ? 234 GLU B CG  1 
ATOM   2254 C CD  . GLU B 2 212 ? 184.353 128.410 157.242 1.00 103.82 ? 234 GLU B CD  1 
ATOM   2255 O OE1 . GLU B 2 212 ? 185.362 127.973 156.650 1.00 103.82 ? 234 GLU B OE1 1 
ATOM   2256 O OE2 . GLU B 2 212 ? 183.885 129.550 157.038 1.00 103.82 ? 234 GLU B OE2 1 
ATOM   2257 N N   . GLU B 2 213 ? 180.124 125.207 155.868 1.00 104.12 ? 235 GLU B N   1 
ATOM   2258 C CA  . GLU B 2 213 ? 179.370 124.024 155.471 1.00 104.12 ? 235 GLU B CA  1 
ATOM   2259 C C   . GLU B 2 213 ? 178.996 124.017 153.999 1.00 104.12 ? 235 GLU B C   1 
ATOM   2260 O O   . GLU B 2 213 ? 179.127 122.983 153.340 1.00 104.12 ? 235 GLU B O   1 
ATOM   2261 C CB  . GLU B 2 213 ? 178.097 123.900 156.315 1.00 104.12 ? 235 GLU B CB  1 
ATOM   2262 C CG  . GLU B 2 213 ? 178.356 123.571 157.775 1.00 104.12 ? 235 GLU B CG  1 
ATOM   2263 C CD  . GLU B 2 213 ? 177.088 123.559 158.603 1.00 104.12 ? 235 GLU B CD  1 
ATOM   2264 O OE1 . GLU B 2 213 ? 177.104 124.104 159.726 1.00 104.12 ? 235 GLU B OE1 1 
ATOM   2265 O OE2 . GLU B 2 213 ? 176.074 123.003 158.131 1.00 104.12 ? 235 GLU B OE2 1 
ATOM   2266 N N   . LEU B 2 214 ? 178.533 125.143 153.464 1.00 101.82 ? 236 LEU B N   1 
ATOM   2267 C CA  . LEU B 2 214 ? 178.233 125.277 152.048 1.00 101.82 ? 236 LEU B CA  1 
ATOM   2268 C C   . LEU B 2 214 ? 179.124 126.352 151.441 1.00 101.82 ? 236 LEU B C   1 
ATOM   2269 O O   . LEU B 2 214 ? 179.466 127.341 152.095 1.00 101.82 ? 236 LEU B O   1 
ATOM   2270 C CB  . LEU B 2 214 ? 176.758 125.623 151.816 1.00 101.82 ? 236 LEU B CB  1 
ATOM   2271 C CG  . LEU B 2 214 ? 175.755 124.547 152.235 1.00 101.82 ? 236 LEU B CG  1 
ATOM   2272 C CD1 . LEU B 2 214 ? 174.348 124.921 151.797 1.00 101.82 ? 236 LEU B CD1 1 
ATOM   2273 C CD2 . LEU B 2 214 ? 176.154 123.192 151.670 1.00 101.82 ? 236 LEU B CD2 1 
ATOM   2274 N N   . SER B 2 215 ? 179.497 126.147 150.179 1.00 96.48  ? 237 SER B N   1 
ATOM   2275 C CA  . SER B 2 215 ? 180.434 127.021 149.485 1.00 96.48  ? 237 SER B CA  1 
ATOM   2276 C C   . SER B 2 215 ? 179.735 127.945 148.493 1.00 96.48  ? 237 SER B C   1 
ATOM   2277 O O   . SER B 2 215 ? 180.334 128.363 147.501 1.00 96.48  ? 237 SER B O   1 
ATOM   2278 C CB  . SER B 2 215 ? 181.503 126.194 148.774 1.00 96.48  ? 237 SER B CB  1 
ATOM   2279 O OG  . SER B 2 215 ? 180.981 125.588 147.604 1.00 96.48  ? 237 SER B OG  1 
ATOM   2280 N N   . SER B 2 216 ? 178.467 128.276 148.745 1.00 93.91  ? 238 SER B N   1 
ATOM   2281 C CA  . SER B 2 216 ? 177.732 129.137 147.828 1.00 93.91  ? 238 SER B CA  1 
ATOM   2282 C C   . SER B 2 216 ? 176.842 130.153 148.533 1.00 93.91  ? 238 SER B C   1 
ATOM   2283 O O   . SER B 2 216 ? 176.034 130.808 147.863 1.00 93.91  ? 238 SER B O   1 
ATOM   2284 C CB  . SER B 2 216 ? 176.881 128.293 146.871 1.00 93.91  ? 238 SER B CB  1 
ATOM   2285 O OG  . SER B 2 216 ? 177.618 127.194 146.365 1.00 93.91  ? 238 SER B OG  1 
ATOM   2286 N N   . ILE B 2 217 ? 176.957 130.316 149.851 1.00 88.79  ? 239 ILE B N   1 
ATOM   2287 C CA  . ILE B 2 217 ? 176.058 131.183 150.599 1.00 88.79  ? 239 ILE B CA  1 
ATOM   2288 C C   . ILE B 2 217 ? 176.862 132.208 151.386 1.00 88.79  ? 239 ILE B C   1 
ATOM   2289 O O   . ILE B 2 217 ? 178.046 132.024 151.676 1.00 88.79  ? 239 ILE B O   1 
ATOM   2290 C CB  . ILE B 2 217 ? 175.135 130.387 151.547 1.00 88.79  ? 239 ILE B CB  1 
ATOM   2291 C CG1 . ILE B 2 217 ? 175.952 129.662 152.615 1.00 88.79  ? 239 ILE B CG1 1 
ATOM   2292 C CG2 . ILE B 2 217 ? 174.295 129.395 150.763 1.00 88.79  ? 239 ILE B CG2 1 
ATOM   2293 C CD1 . ILE B 2 217 ? 175.111 128.828 153.554 1.00 88.79  ? 239 ILE B CD1 1 
ATOM   2294 N N   . LEU B 2 218 ? 176.190 133.306 151.724 1.00 86.86  ? 240 LEU B N   1 
ATOM   2295 C CA  . LEU B 2 218 ? 176.757 134.367 152.544 1.00 86.86  ? 240 LEU B CA  1 
ATOM   2296 C C   . LEU B 2 218 ? 175.648 134.941 153.411 1.00 86.86  ? 240 LEU B C   1 
ATOM   2297 O O   . LEU B 2 218 ? 174.491 135.004 152.986 1.00 86.86  ? 240 LEU B O   1 
ATOM   2298 C CB  . LEU B 2 218 ? 177.390 135.468 151.687 1.00 86.86  ? 240 LEU B CB  1 
ATOM   2299 C CG  . LEU B 2 218 ? 178.775 135.176 151.109 1.00 86.86  ? 240 LEU B CG  1 
ATOM   2300 C CD1 . LEU B 2 218 ? 179.263 136.346 150.274 1.00 86.86  ? 240 LEU B CD1 1 
ATOM   2301 C CD2 . LEU B 2 218 ? 179.757 134.863 152.222 1.00 86.86  ? 240 LEU B CD2 1 
ATOM   2302 N N   . LYS B 2 219 ? 176.003 135.358 154.623 1.00 88.16  ? 241 LYS B N   1 
ATOM   2303 C CA  . LYS B 2 219 ? 175.040 135.844 155.603 1.00 88.16  ? 241 LYS B CA  1 
ATOM   2304 C C   . LYS B 2 219 ? 175.278 137.327 155.852 1.00 88.16  ? 241 LYS B C   1 
ATOM   2305 O O   . LYS B 2 219 ? 176.409 137.740 156.130 1.00 88.16  ? 241 LYS B O   1 
ATOM   2306 C CB  . LYS B 2 219 ? 175.148 135.047 156.903 1.00 88.16  ? 241 LYS B CB  1 
ATOM   2307 C CG  . LYS B 2 219 ? 175.171 133.544 156.684 1.00 88.16  ? 241 LYS B CG  1 
ATOM   2308 C CD  . LYS B 2 219 ? 175.480 132.792 157.965 1.00 88.16  ? 241 LYS B CD  1 
ATOM   2309 C CE  . LYS B 2 219 ? 175.603 131.300 157.703 1.00 88.16  ? 241 LYS B CE  1 
ATOM   2310 N NZ  . LYS B 2 219 ? 175.940 130.542 158.939 1.00 88.16  ? 241 LYS B NZ  1 
ATOM   2311 N N   . LEU B 2 220 ? 174.215 138.121 155.750 1.00 80.38  ? 242 LEU B N   1 
ATOM   2312 C CA  . LEU B 2 220 ? 174.286 139.565 155.927 1.00 80.38  ? 242 LEU B CA  1 
ATOM   2313 C C   . LEU B 2 220 ? 173.644 139.962 157.250 1.00 80.38  ? 242 LEU B C   1 
ATOM   2314 O O   . LEU B 2 220 ? 172.547 139.497 157.577 1.00 80.38  ? 242 LEU B O   1 
ATOM   2315 C CB  . LEU B 2 220 ? 173.593 140.289 154.771 1.00 80.38  ? 242 LEU B CB  1 
ATOM   2316 C CG  . LEU B 2 220 ? 174.465 140.730 153.594 1.00 80.38  ? 242 LEU B CG  1 
ATOM   2317 C CD1 . LEU B 2 220 ? 175.461 141.787 154.042 1.00 80.38  ? 242 LEU B CD1 1 
ATOM   2318 C CD2 . LEU B 2 220 ? 175.182 139.546 152.962 1.00 80.38  ? 242 LEU B CD2 1 
ATOM   2319 N N   . THR B 2 221 ? 174.329 140.819 158.006 1.00 76.75  ? 243 THR B N   1 
ATOM   2320 C CA  . THR B 2 221 ? 173.822 141.352 159.262 1.00 76.75  ? 243 THR B CA  1 
ATOM   2321 C C   . THR B 2 221 ? 173.989 142.864 159.273 1.00 76.75  ? 243 THR B C   1 
ATOM   2322 O O   . THR B 2 221 ? 174.982 143.390 158.760 1.00 76.75  ? 243 THR B O   1 
ATOM   2323 C CB  . THR B 2 221 ? 174.545 140.751 160.477 1.00 76.75  ? 243 THR B CB  1 
ATOM   2324 O OG1 . THR B 2 221 ? 175.822 141.381 160.634 1.00 76.75  ? 243 THR B OG1 1 
ATOM   2325 C CG2 . THR B 2 221 ? 174.738 139.250 160.313 1.00 76.75  ? 243 THR B CG2 1 
ATOM   2326 N N   . TRP B 2 222 ? 173.019 143.559 159.864 1.00 70.29  ? 244 TRP B N   1 
ATOM   2327 C CA  . TRP B 2 222 ? 173.052 145.012 159.940 1.00 70.29  ? 244 TRP B CA  1 
ATOM   2328 C C   . TRP B 2 222 ? 172.282 145.461 161.174 1.00 70.29  ? 244 TRP B C   1 
ATOM   2329 O O   . TRP B 2 222 ? 171.754 144.647 161.935 1.00 70.29  ? 244 TRP B O   1 
ATOM   2330 C CB  . TRP B 2 222 ? 172.473 145.655 158.675 1.00 70.29  ? 244 TRP B CB  1 
ATOM   2331 C CG  . TRP B 2 222 ? 171.068 145.233 158.376 1.00 70.29  ? 244 TRP B CG  1 
ATOM   2332 C CD1 . TRP B 2 222 ? 169.935 145.649 159.011 1.00 70.29  ? 244 TRP B CD1 1 
ATOM   2333 C CD2 . TRP B 2 222 ? 170.644 144.314 157.363 1.00 70.29  ? 244 TRP B CD2 1 
ATOM   2334 N NE1 . TRP B 2 222 ? 168.833 145.043 158.460 1.00 70.29  ? 244 TRP B NE1 1 
ATOM   2335 C CE2 . TRP B 2 222 ? 169.242 144.219 157.445 1.00 70.29  ? 244 TRP B CE2 1 
ATOM   2336 C CE3 . TRP B 2 222 ? 171.315 143.561 156.397 1.00 70.29  ? 244 TRP B CE3 1 
ATOM   2337 C CZ2 . TRP B 2 222 ? 168.499 143.403 156.598 1.00 70.29  ? 244 TRP B CZ2 1 
ATOM   2338 C CZ3 . TRP B 2 222 ? 170.575 142.751 155.556 1.00 70.29  ? 244 TRP B CZ3 1 
ATOM   2339 C CH2 . TRP B 2 222 ? 169.182 142.679 155.662 1.00 70.29  ? 244 TRP B CH2 1 
ATOM   2340 N N   . THR B 2 223 ? 172.224 146.778 161.363 1.00 71.02  ? 245 THR B N   1 
ATOM   2341 C CA  . THR B 2 223 ? 171.523 147.391 162.486 1.00 71.02  ? 245 THR B CA  1 
ATOM   2342 C C   . THR B 2 223 ? 170.590 148.470 161.957 1.00 71.02  ? 245 THR B C   1 
ATOM   2343 O O   . THR B 2 223 ? 171.038 149.415 161.299 1.00 71.02  ? 245 THR B O   1 
ATOM   2344 C CB  . THR B 2 223 ? 172.510 147.987 163.493 1.00 71.02  ? 245 THR B CB  1 
ATOM   2345 O OG1 . THR B 2 223 ? 173.360 148.929 162.829 1.00 71.02  ? 245 THR B OG1 1 
ATOM   2346 C CG2 . THR B 2 223 ? 173.363 146.894 164.118 1.00 71.02  ? 245 THR B CG2 1 
ATOM   2347 N N   . ASN B 2 224 ? 169.300 148.333 162.249 1.00 60.41  ? 246 ASN B N   1 
ATOM   2348 C CA  . ASN B 2 224 ? 168.308 149.294 161.800 1.00 60.41  ? 246 ASN B CA  1 
ATOM   2349 C C   . ASN B 2 224 ? 168.314 150.534 162.690 1.00 60.41  ? 246 ASN B C   1 
ATOM   2350 O O   . ASN B 2 224 ? 168.710 150.473 163.856 1.00 60.41  ? 246 ASN B O   1 
ATOM   2351 C CB  . ASN B 2 224 ? 166.922 148.657 161.802 1.00 60.41  ? 246 ASN B CB  1 
ATOM   2352 C CG  . ASN B 2 224 ? 166.781 147.563 160.765 1.00 60.41  ? 246 ASN B CG  1 
ATOM   2353 O OD1 . ASN B 2 224 ? 167.550 147.498 159.807 1.00 60.41  ? 246 ASN B OD1 1 
ATOM   2354 N ND2 . ASN B 2 224 ? 165.789 146.700 160.946 1.00 60.41  ? 246 ASN B ND2 1 
ATOM   2355 N N   . PRO B 2 225 ? 167.881 151.674 162.163 1.00 59.72  ? 247 PRO B N   1 
ATOM   2356 C CA  . PRO B 2 225 ? 167.780 152.892 162.973 1.00 59.72  ? 247 PRO B CA  1 
ATOM   2357 C C   . PRO B 2 225 ? 166.605 152.803 163.944 1.00 59.72  ? 247 PRO B C   1 
ATOM   2358 O O   . PRO B 2 225 ? 165.916 151.789 164.040 1.00 59.72  ? 247 PRO B O   1 
ATOM   2359 C CB  . PRO B 2 225 ? 167.566 153.997 161.932 1.00 59.72  ? 247 PRO B CB  1 
ATOM   2360 C CG  . PRO B 2 225 ? 167.961 153.393 160.623 1.00 59.72  ? 247 PRO B CG  1 
ATOM   2361 C CD  . PRO B 2 225 ? 167.630 151.945 160.739 1.00 59.72  ? 247 PRO B CD  1 
ATOM   2362 N N   . SER B 2 226 ? 166.382 153.900 164.668 1.00 60.22  ? 248 SER B N   1 
ATOM   2363 C CA  . SER B 2 226 ? 165.341 153.946 165.688 1.00 60.22  ? 248 SER B CA  1 
ATOM   2364 C C   . SER B 2 226 ? 163.939 154.101 165.114 1.00 60.22  ? 248 SER B C   1 
ATOM   2365 O O   . SER B 2 226 ? 162.966 153.982 165.866 1.00 60.22  ? 248 SER B O   1 
ATOM   2366 C CB  . SER B 2 226 ? 165.617 155.090 166.666 1.00 60.22  ? 248 SER B CB  1 
ATOM   2367 O OG  . SER B 2 226 ? 164.431 155.484 167.333 1.00 60.22  ? 248 SER B OG  1 
ATOM   2368 N N   . ILE B 2 227 ? 163.808 154.364 163.812 1.00 55.78  ? 249 ILE B N   1 
ATOM   2369 C CA  . ILE B 2 227 ? 162.488 154.519 163.213 1.00 55.78  ? 249 ILE B CA  1 
ATOM   2370 C C   . ILE B 2 227 ? 161.759 153.184 163.112 1.00 55.78  ? 249 ILE B C   1 
ATOM   2371 O O   . ILE B 2 227 ? 160.535 153.160 162.941 1.00 55.78  ? 249 ILE B O   1 
ATOM   2372 C CB  . ILE B 2 227 ? 162.624 155.203 161.839 1.00 55.78  ? 249 ILE B CB  1 
ATOM   2373 C CG1 . ILE B 2 227 ? 163.433 156.489 161.979 1.00 55.78  ? 249 ILE B CG1 1 
ATOM   2374 C CG2 . ILE B 2 227 ? 161.265 155.549 161.255 1.00 55.78  ? 249 ILE B CG2 1 
ATOM   2375 C CD1 . ILE B 2 227 ? 162.761 157.520 162.858 1.00 55.78  ? 249 ILE B CD1 1 
ATOM   2376 N N   . LYS B 2 228 ? 162.479 152.066 163.243 1.00 53.88  ? 250 LYS B N   1 
ATOM   2377 C CA  . LYS B 2 228 ? 161.846 150.754 163.145 1.00 53.88  ? 250 LYS B CA  1 
ATOM   2378 C C   . LYS B 2 228 ? 160.747 150.573 164.185 1.00 53.88  ? 250 LYS B C   1 
ATOM   2379 O O   . LYS B 2 228 ? 159.829 149.771 163.984 1.00 53.88  ? 250 LYS B O   1 
ATOM   2380 C CB  . LYS B 2 228 ? 162.896 149.653 163.292 1.00 53.88  ? 250 LYS B CB  1 
ATOM   2381 C CG  . LYS B 2 228 ? 163.617 149.662 164.630 1.00 53.88  ? 250 LYS B CG  1 
ATOM   2382 C CD  . LYS B 2 228 ? 164.715 148.614 164.677 1.00 53.88  ? 250 LYS B CD  1 
ATOM   2383 C CE  . LYS B 2 228 ? 165.496 148.695 165.977 1.00 53.88  ? 250 LYS B CE  1 
ATOM   2384 N NZ  . LYS B 2 228 ? 166.160 150.018 166.139 1.00 53.88  ? 250 LYS B NZ  1 
ATOM   2385 N N   . SER B 2 229 ? 160.820 151.305 165.298 1.00 55.20  ? 251 SER B N   1 
ATOM   2386 C CA  . SER B 2 229 ? 159.791 151.205 166.325 1.00 55.20  ? 251 SER B CA  1 
ATOM   2387 C C   . SER B 2 229 ? 158.545 152.006 165.970 1.00 55.20  ? 251 SER B C   1 
ATOM   2388 O O   . SER B 2 229 ? 157.463 151.724 166.495 1.00 55.20  ? 251 SER B O   1 
ATOM   2389 C CB  . SER B 2 229 ? 160.344 151.675 167.671 1.00 55.20  ? 251 SER B CB  1 
ATOM   2390 O OG  . SER B 2 229 ? 160.266 153.084 167.788 1.00 55.20  ? 251 SER B OG  1 
ATOM   2391 N N   . VAL B 2 230 ? 158.674 153.000 165.092 1.00 54.26  ? 252 VAL B N   1 
ATOM   2392 C CA  . VAL B 2 230 ? 157.530 153.834 164.740 1.00 54.26  ? 252 VAL B CA  1 
ATOM   2393 C C   . VAL B 2 230 ? 156.761 153.236 163.568 1.00 54.26  ? 252 VAL B C   1 
ATOM   2394 O O   . VAL B 2 230 ? 155.535 153.090 163.622 1.00 54.26  ? 252 VAL B O   1 
ATOM   2395 C CB  . VAL B 2 230 ? 157.991 155.272 164.437 1.00 54.26  ? 252 VAL B CB  1 
ATOM   2396 C CG1 . VAL B 2 230 ? 156.808 156.133 164.028 1.00 54.26  ? 252 VAL B CG1 1 
ATOM   2397 C CG2 . VAL B 2 230 ? 158.696 155.866 165.644 1.00 54.26  ? 252 VAL B CG2 1 
ATOM   2398 N N   . ILE B 2 231 ? 157.467 152.880 162.493 1.00 53.81  ? 253 ILE B N   1 
ATOM   2399 C CA  . ILE B 2 231 ? 156.840 152.405 161.267 1.00 53.81  ? 253 ILE B CA  1 
ATOM   2400 C C   . ILE B 2 231 ? 157.566 151.163 160.770 1.00 53.81  ? 253 ILE B C   1 
ATOM   2401 O O   . ILE B 2 231 ? 158.728 150.917 161.099 1.00 53.81  ? 253 ILE B O   1 
ATOM   2402 C CB  . ILE B 2 231 ? 156.837 153.483 160.162 1.00 53.81  ? 253 ILE B CB  1 
ATOM   2403 C CG1 . ILE B 2 231 ? 158.263 153.968 159.897 1.00 53.81  ? 253 ILE B CG1 1 
ATOM   2404 C CG2 . ILE B 2 231 ? 155.934 154.642 160.548 1.00 53.81  ? 253 ILE B CG2 1 
ATOM   2405 C CD1 . ILE B 2 231 ? 158.350 155.109 158.912 1.00 53.81  ? 253 ILE B CD1 1 
ATOM   2406 N N   . ILE B 2 232 ? 156.857 150.376 159.967 1.00 57.77  ? 254 ILE B N   1 
ATOM   2407 C CA  . ILE B 2 232 ? 157.452 149.230 159.291 1.00 57.77  ? 254 ILE B CA  1 
ATOM   2408 C C   . ILE B 2 232 ? 158.172 149.718 158.043 1.00 57.77  ? 254 ILE B C   1 
ATOM   2409 O O   . ILE B 2 232 ? 157.673 150.587 157.319 1.00 57.77  ? 254 ILE B O   1 
ATOM   2410 C CB  . ILE B 2 232 ? 156.376 148.186 158.948 1.00 57.77  ? 254 ILE B CB  1 
ATOM   2411 C CG1 . ILE B 2 232 ? 155.470 147.939 160.154 1.00 57.77  ? 254 ILE B CG1 1 
ATOM   2412 C CG2 . ILE B 2 232 ? 157.018 146.887 158.493 1.00 57.77  ? 254 ILE B CG2 1 
ATOM   2413 C CD1 . ILE B 2 232 ? 154.369 146.937 159.893 1.00 57.77  ? 254 ILE B CD1 1 
ATOM   2414 N N   . LEU B 2 233 ? 159.352 149.162 157.783 1.00 55.67  ? 255 LEU B N   1 
ATOM   2415 C CA  . LEU B 2 233 ? 160.200 149.628 156.697 1.00 55.67  ? 255 LEU B CA  1 
ATOM   2416 C C   . LEU B 2 233 ? 160.699 148.448 155.874 1.00 55.67  ? 255 LEU B C   1 
ATOM   2417 O O   . LEU B 2 233 ? 160.796 147.318 156.359 1.00 55.67  ? 255 LEU B O   1 
ATOM   2418 C CB  . LEU B 2 233 ? 161.387 150.450 157.227 1.00 55.67  ? 255 LEU B CB  1 
ATOM   2419 C CG  . LEU B 2 233 ? 162.536 149.743 157.946 1.00 55.67  ? 255 LEU B CG  1 
ATOM   2420 C CD1 . LEU B 2 233 ? 163.752 150.653 157.994 1.00 55.67  ? 255 LEU B CD1 1 
ATOM   2421 C CD2 . LEU B 2 233 ? 162.135 149.328 159.351 1.00 55.67  ? 255 LEU B CD2 1 
ATOM   2422 N N   . LYS B 2 234 ? 161.014 148.731 154.612 1.00 57.82  ? 256 LYS B N   1 
ATOM   2423 C CA  . LYS B 2 234 ? 161.504 147.741 153.667 1.00 57.82  ? 256 LYS B CA  1 
ATOM   2424 C C   . LYS B 2 234 ? 162.891 148.138 153.179 1.00 57.82  ? 256 LYS B C   1 
ATOM   2425 O O   . LYS B 2 234 ? 163.309 149.291 153.308 1.00 57.82  ? 256 LYS B O   1 
ATOM   2426 C CB  . LYS B 2 234 ? 160.554 147.590 152.474 1.00 57.82  ? 256 LYS B CB  1 
ATOM   2427 C CG  . LYS B 2 234 ? 160.470 148.825 151.595 1.00 57.82  ? 256 LYS B CG  1 
ATOM   2428 C CD  . LYS B 2 234 ? 159.497 148.619 150.446 1.00 57.82  ? 256 LYS B CD  1 
ATOM   2429 C CE  . LYS B 2 234 ? 159.414 149.853 149.565 1.00 57.82  ? 256 LYS B CE  1 
ATOM   2430 N NZ  . LYS B 2 234 ? 158.464 149.661 148.435 1.00 57.82  ? 256 LYS B NZ  1 
ATOM   2431 N N   . TYR B 2 235 ? 163.600 147.170 152.603 1.00 58.28  ? 257 TYR B N   1 
ATOM   2432 C CA  . TYR B 2 235 ? 164.985 147.353 152.199 1.00 58.28  ? 257 TYR B CA  1 
ATOM   2433 C C   . TYR B 2 235 ? 165.168 146.964 150.739 1.00 58.28  ? 257 TYR B C   1 
ATOM   2434 O O   . TYR B 2 235 ? 164.283 146.384 150.104 1.00 58.28  ? 257 TYR B O   1 
ATOM   2435 C CB  . TYR B 2 235 ? 165.940 146.526 153.072 1.00 58.28  ? 257 TYR B CB  1 
ATOM   2436 C CG  . TYR B 2 235 ? 165.591 146.496 154.542 1.00 58.28  ? 257 TYR B CG  1 
ATOM   2437 C CD1 . TYR B 2 235 ? 166.086 147.456 155.413 1.00 58.28  ? 257 TYR B CD1 1 
ATOM   2438 C CD2 . TYR B 2 235 ? 164.779 145.498 155.063 1.00 58.28  ? 257 TYR B CD2 1 
ATOM   2439 C CE1 . TYR B 2 235 ? 165.775 147.429 156.757 1.00 58.28  ? 257 TYR B CE1 1 
ATOM   2440 C CE2 . TYR B 2 235 ? 164.463 145.463 156.406 1.00 58.28  ? 257 TYR B CE2 1 
ATOM   2441 C CZ  . TYR B 2 235 ? 164.963 146.430 157.248 1.00 58.28  ? 257 TYR B CZ  1 
ATOM   2442 O OH  . TYR B 2 235 ? 164.650 146.398 158.588 1.00 58.28  ? 257 TYR B OH  1 
ATOM   2443 N N   . ASN B 2 236 ? 166.344 147.299 150.211 1.00 65.93  ? 258 ASN B N   1 
ATOM   2444 C CA  . ASN B 2 236 ? 166.803 146.833 148.908 1.00 65.93  ? 258 ASN B CA  1 
ATOM   2445 C C   . ASN B 2 236 ? 168.258 146.415 149.042 1.00 65.93  ? 258 ASN B C   1 
ATOM   2446 O O   . ASN B 2 236 ? 169.108 147.234 149.403 1.00 65.93  ? 258 ASN B O   1 
ATOM   2447 C CB  . ASN B 2 236 ? 166.653 147.911 147.833 1.00 65.93  ? 258 ASN B CB  1 
ATOM   2448 C CG  . ASN B 2 236 ? 165.255 147.972 147.264 1.00 65.93  ? 258 ASN B CG  1 
ATOM   2449 O OD1 . ASN B 2 236 ? 164.617 149.022 147.261 1.00 65.93  ? 258 ASN B OD1 1 
ATOM   2450 N ND2 . ASN B 2 236 ? 164.767 146.838 146.778 1.00 65.93  ? 258 ASN B ND2 1 
ATOM   2451 N N   . ILE B 2 237 ? 168.542 145.150 148.750 1.00 71.23  ? 259 ILE B N   1 
ATOM   2452 C CA  . ILE B 2 237 ? 169.872 144.579 148.918 1.00 71.23  ? 259 ILE B CA  1 
ATOM   2453 C C   . ILE B 2 237 ? 170.505 144.450 147.540 1.00 71.23  ? 259 ILE B C   1 
ATOM   2454 O O   . ILE B 2 237 ? 170.013 143.702 146.686 1.00 71.23  ? 259 ILE B O   1 
ATOM   2455 C CB  . ILE B 2 237 ? 169.824 143.225 149.636 1.00 71.23  ? 259 ILE B CB  1 
ATOM   2456 C CG1 . ILE B 2 237 ? 169.005 143.338 150.922 1.00 71.23  ? 259 ILE B CG1 1 
ATOM   2457 C CG2 . ILE B 2 237 ? 171.230 142.737 149.943 1.00 71.23  ? 259 ILE B CG2 1 
ATOM   2458 C CD1 . ILE B 2 237 ? 168.972 142.068 151.737 1.00 71.23  ? 259 ILE B CD1 1 
ATOM   2459 N N   . GLN B 2 238 ? 171.595 145.176 147.320 1.00 76.69  ? 260 GLN B N   1 
ATOM   2460 C CA  . GLN B 2 238 ? 172.346 145.113 146.076 1.00 76.69  ? 260 GLN B CA  1 
ATOM   2461 C C   . GLN B 2 238 ? 173.736 144.554 146.345 1.00 76.69  ? 260 GLN B C   1 
ATOM   2462 O O   . GLN B 2 238 ? 174.369 144.896 147.348 1.00 76.69  ? 260 GLN B O   1 
ATOM   2463 C CB  . GLN B 2 238 ? 172.450 146.494 145.425 1.00 76.69  ? 260 GLN B CB  1 
ATOM   2464 C CG  . GLN B 2 238 ? 171.138 147.006 144.853 1.00 76.69  ? 260 GLN B CG  1 
ATOM   2465 C CD  . GLN B 2 238 ? 171.313 148.266 144.029 1.00 76.69  ? 260 GLN B CD  1 
ATOM   2466 O OE1 . GLN B 2 238 ? 172.331 148.951 144.130 1.00 76.69  ? 260 GLN B OE1 1 
ATOM   2467 N NE2 . GLN B 2 238 ? 170.320 148.576 143.204 1.00 76.69  ? 260 GLN B NE2 1 
ATOM   2468 N N   . TYR B 2 239 ? 174.203 143.689 145.446 1.00 78.48  ? 261 TYR B N   1 
ATOM   2469 C CA  . TYR B 2 239 ? 175.508 143.060 145.572 1.00 78.48  ? 261 TYR B CA  1 
ATOM   2470 C C   . TYR B 2 239 ? 176.168 143.004 144.204 1.00 78.48  ? 261 TYR B C   1 
ATOM   2471 O O   . TYR B 2 239 ? 175.542 143.275 143.176 1.00 78.48  ? 261 TYR B O   1 
ATOM   2472 C CB  . TYR B 2 239 ? 175.404 141.652 146.172 1.00 78.48  ? 261 TYR B CB  1 
ATOM   2473 C CG  . TYR B 2 239 ? 174.730 140.641 145.270 1.00 78.48  ? 261 TYR B CG  1 
ATOM   2474 C CD1 . TYR B 2 239 ? 173.347 140.543 145.216 1.00 78.48  ? 261 TYR B CD1 1 
ATOM   2475 C CD2 . TYR B 2 239 ? 175.478 139.780 144.477 1.00 78.48  ? 261 TYR B CD2 1 
ATOM   2476 C CE1 . TYR B 2 239 ? 172.728 139.620 144.396 1.00 78.48  ? 261 TYR B CE1 1 
ATOM   2477 C CE2 . TYR B 2 239 ? 174.867 138.854 143.654 1.00 78.48  ? 261 TYR B CE2 1 
ATOM   2478 C CZ  . TYR B 2 239 ? 173.492 138.779 143.618 1.00 78.48  ? 261 TYR B CZ  1 
ATOM   2479 O OH  . TYR B 2 239 ? 172.878 137.859 142.800 1.00 78.48  ? 261 TYR B OH  1 
ATOM   2480 N N   . ARG B 2 240 ? 177.447 142.640 144.200 1.00 84.62  ? 262 ARG B N   1 
ATOM   2481 C CA  . ARG B 2 240 ? 178.209 142.515 142.965 1.00 84.62  ? 262 ARG B CA  1 
ATOM   2482 C C   . ARG B 2 240 ? 179.499 141.770 143.265 1.00 84.62  ? 262 ARG B C   1 
ATOM   2483 O O   . ARG B 2 240 ? 179.899 141.627 144.424 1.00 84.62  ? 262 ARG B O   1 
ATOM   2484 C CB  . ARG B 2 240 ? 178.510 143.883 142.345 1.00 84.62  ? 262 ARG B CB  1 
ATOM   2485 C CG  . ARG B 2 240 ? 179.578 144.669 143.075 1.00 84.62  ? 262 ARG B CG  1 
ATOM   2486 C CD  . ARG B 2 240 ? 179.988 145.902 142.294 1.00 84.62  ? 262 ARG B CD  1 
ATOM   2487 N NE  . ARG B 2 240 ? 181.011 146.670 142.995 1.00 84.62  ? 262 ARG B NE  1 
ATOM   2488 C CZ  . ARG B 2 240 ? 182.313 146.418 142.920 1.00 84.62  ? 262 ARG B CZ  1 
ATOM   2489 N NH1 . ARG B 2 240 ? 182.752 145.412 142.176 1.00 84.62  ? 262 ARG B NH1 1 
ATOM   2490 N NH2 . ARG B 2 240 ? 183.176 147.168 143.592 1.00 84.62  ? 262 ARG B NH2 1 
ATOM   2491 N N   . THR B 2 241 ? 180.142 141.295 142.203 1.00 88.13  ? 263 THR B N   1 
ATOM   2492 C CA  . THR B 2 241 ? 181.422 140.620 142.325 1.00 88.13  ? 263 THR B CA  1 
ATOM   2493 C C   . THR B 2 241 ? 182.542 141.658 142.418 1.00 88.13  ? 263 THR B C   1 
ATOM   2494 O O   . THR B 2 241 ? 182.399 142.801 141.977 1.00 88.13  ? 263 THR B O   1 
ATOM   2495 C CB  . THR B 2 241 ? 181.639 139.679 141.135 1.00 88.13  ? 263 THR B CB  1 
ATOM   2496 O OG1 . THR B 2 241 ? 180.491 138.837 140.986 1.00 88.13  ? 263 THR B OG1 1 
ATOM   2497 C CG2 . THR B 2 241 ? 182.849 138.783 141.358 1.00 88.13  ? 263 THR B CG2 1 
ATOM   2498 N N   . LYS B 2 242 ? 183.661 141.250 143.023 1.00 91.58  ? 264 LYS B N   1 
ATOM   2499 C CA  . LYS B 2 242 ? 184.759 142.182 143.266 1.00 91.58  ? 264 LYS B CA  1 
ATOM   2500 C C   . LYS B 2 242 ? 185.276 142.797 141.970 1.00 91.58  ? 264 LYS B C   1 
ATOM   2501 O O   . LYS B 2 242 ? 185.539 144.004 141.911 1.00 91.58  ? 264 LYS B O   1 
ATOM   2502 C CB  . LYS B 2 242 ? 185.890 141.476 144.011 1.00 91.58  ? 264 LYS B CB  1 
ATOM   2503 C CG  . LYS B 2 242 ? 187.075 142.373 144.320 1.00 91.58  ? 264 LYS B CG  1 
ATOM   2504 C CD  . LYS B 2 242 ? 186.648 143.577 145.141 1.00 91.58  ? 264 LYS B CD  1 
ATOM   2505 C CE  . LYS B 2 242 ? 187.763 144.604 145.236 1.00 91.58  ? 264 LYS B CE  1 
ATOM   2506 N NZ  . LYS B 2 242 ? 188.166 145.111 143.896 1.00 91.58  ? 264 LYS B NZ  1 
ATOM   2507 N N   . ASP B 2 243 ? 185.428 141.988 140.920 1.00 96.40  ? 265 ASP B N   1 
ATOM   2508 C CA  . ASP B 2 243 ? 185.966 142.511 139.667 1.00 96.40  ? 265 ASP B CA  1 
ATOM   2509 C C   . ASP B 2 243 ? 184.882 143.098 138.772 1.00 96.40  ? 265 ASP B C   1 
ATOM   2510 O O   . ASP B 2 243 ? 185.188 143.914 137.895 1.00 96.40  ? 265 ASP B O   1 
ATOM   2511 C CB  . ASP B 2 243 ? 186.726 141.414 138.919 1.00 96.40  ? 265 ASP B CB  1 
ATOM   2512 C CG  . ASP B 2 243 ? 185.931 140.131 138.799 1.00 96.40  ? 265 ASP B CG  1 
ATOM   2513 O OD1 . ASP B 2 243 ? 185.490 139.607 139.842 1.00 96.40  ? 265 ASP B OD1 1 
ATOM   2514 O OD2 . ASP B 2 243 ? 185.750 139.645 137.663 1.00 96.40  ? 265 ASP B OD2 1 
ATOM   2515 N N   . ALA B 2 244 ? 183.627 142.707 138.971 1.00 94.64  ? 266 ALA B N   1 
ATOM   2516 C CA  . ALA B 2 244 ? 182.520 143.207 138.165 1.00 94.64  ? 266 ALA B CA  1 
ATOM   2517 C C   . ALA B 2 244 ? 182.029 144.527 138.746 1.00 94.64  ? 266 ALA B C   1 
ATOM   2518 O O   . ALA B 2 244 ? 181.635 144.587 139.916 1.00 94.64  ? 266 ALA B O   1 
ATOM   2519 C CB  . ALA B 2 244 ? 181.386 142.186 138.109 1.00 94.64  ? 266 ALA B CB  1 
ATOM   2520 N N   . SER B 2 245 ? 182.052 145.583 137.930 1.00 97.12  ? 267 SER B N   1 
ATOM   2521 C CA  . SER B 2 245 ? 181.627 146.900 138.388 1.00 97.12  ? 267 SER B CA  1 
ATOM   2522 C C   . SER B 2 245 ? 180.113 147.063 138.399 1.00 97.12  ? 267 SER B C   1 
ATOM   2523 O O   . SER B 2 245 ? 179.603 147.919 139.130 1.00 97.12  ? 267 SER B O   1 
ATOM   2524 C CB  . SER B 2 245 ? 182.251 147.990 137.515 1.00 97.12  ? 267 SER B CB  1 
ATOM   2525 O OG  . SER B 2 245 ? 181.511 149.195 137.601 1.00 97.12  ? 267 SER B OG  1 
ATOM   2526 N N   . THR B 2 246 ? 179.388 146.274 137.610 1.00 93.76  ? 268 THR B N   1 
ATOM   2527 C CA  . THR B 2 246 ? 177.937 146.382 137.585 1.00 93.76  ? 268 THR B CA  1 
ATOM   2528 C C   . THR B 2 246 ? 177.340 145.834 138.875 1.00 93.76  ? 268 THR B C   1 
ATOM   2529 O O   . THR B 2 246 ? 177.711 144.753 139.342 1.00 93.76  ? 268 THR B O   1 
ATOM   2530 C CB  . THR B 2 246 ? 177.369 145.630 136.381 1.00 93.76  ? 268 THR B CB  1 
ATOM   2531 O OG1 . THR B 2 246 ? 178.127 145.959 135.210 1.00 93.76  ? 268 THR B OG1 1 
ATOM   2532 C CG2 . THR B 2 246 ? 175.911 146.005 136.157 1.00 93.76  ? 268 THR B CG2 1 
ATOM   2533 N N   . TRP B 2 247 ? 176.406 146.586 139.450 1.00 83.84  ? 269 TRP B N   1 
ATOM   2534 C CA  . TRP B 2 247 ? 175.767 146.224 140.708 1.00 83.84  ? 269 TRP B CA  1 
ATOM   2535 C C   . TRP B 2 247 ? 174.453 145.511 140.419 1.00 83.84  ? 269 TRP B C   1 
ATOM   2536 O O   . TRP B 2 247 ? 173.535 146.104 139.842 1.00 83.84  ? 269 TRP B O   1 
ATOM   2537 C CB  . TRP B 2 247 ? 175.519 147.462 141.569 1.00 83.84  ? 269 TRP B CB  1 
ATOM   2538 C CG  . TRP B 2 247 ? 176.758 148.054 142.164 1.00 83.84  ? 269 TRP B CG  1 
ATOM   2539 C CD1 . TRP B 2 247 ? 177.665 148.857 141.539 1.00 83.84  ? 269 TRP B CD1 1 
ATOM   2540 C CD2 . TRP B 2 247 ? 177.220 147.900 143.511 1.00 83.84  ? 269 TRP B CD2 1 
ATOM   2541 N NE1 . TRP B 2 247 ? 178.667 149.209 142.411 1.00 83.84  ? 269 TRP B NE1 1 
ATOM   2542 C CE2 . TRP B 2 247 ? 178.416 148.635 143.629 1.00 83.84  ? 269 TRP B CE2 1 
ATOM   2543 C CE3 . TRP B 2 247 ? 176.740 147.211 144.629 1.00 83.84  ? 269 TRP B CE3 1 
ATOM   2544 C CZ2 . TRP B 2 247 ? 179.139 148.698 144.817 1.00 83.84  ? 269 TRP B CZ2 1 
ATOM   2545 C CZ3 . TRP B 2 247 ? 177.459 147.275 145.807 1.00 83.84  ? 269 TRP B CZ3 1 
ATOM   2546 C CH2 . TRP B 2 247 ? 178.645 148.014 145.893 1.00 83.84  ? 269 TRP B CH2 1 
ATOM   2547 N N   . SER B 2 248 ? 174.364 144.247 140.817 1.00 80.54  ? 270 SER B N   1 
ATOM   2548 C CA  . SER B 2 248 ? 173.122 143.500 140.711 1.00 80.54  ? 270 SER B CA  1 
ATOM   2549 C C   . SER B 2 248 ? 172.245 143.770 141.927 1.00 80.54  ? 270 SER B C   1 
ATOM   2550 O O   . SER B 2 248 ? 172.723 144.158 142.995 1.00 80.54  ? 270 SER B O   1 
ATOM   2551 C CB  . SER B 2 248 ? 173.397 142.002 140.581 1.00 80.54  ? 270 SER B CB  1 
ATOM   2552 O OG  . SER B 2 248 ? 172.223 141.302 140.210 1.00 80.54  ? 270 SER B OG  1 
ATOM   2553 N N   . GLN B 2 249 ? 170.943 143.561 141.754 1.00 81.33  ? 271 GLN B N   1 
ATOM   2554 C CA  . GLN B 2 249 ? 169.959 143.843 142.790 1.00 81.33  ? 271 GLN B CA  1 
ATOM   2555 C C   . GLN B 2 249 ? 169.152 142.592 143.095 1.00 81.33  ? 271 GLN B C   1 
ATOM   2556 O O   . GLN B 2 249 ? 168.677 141.914 142.178 1.00 81.33  ? 271 GLN B O   1 
ATOM   2557 C CB  . GLN B 2 249 ? 169.022 144.978 142.369 1.00 81.33  ? 271 GLN B CB  1 
ATOM   2558 C CG  . GLN B 2 249 ? 167.960 145.314 143.403 1.00 81.33  ? 271 GLN B CG  1 
ATOM   2559 C CD  . GLN B 2 249 ? 166.873 146.213 142.853 1.00 81.33  ? 271 GLN B CD  1 
ATOM   2560 O OE1 . GLN B 2 249 ? 166.240 146.966 143.593 1.00 81.33  ? 271 GLN B OE1 1 
ATOM   2561 N NE2 . GLN B 2 249 ? 166.646 146.137 141.547 1.00 81.33  ? 271 GLN B NE2 1 
ATOM   2562 N N   . ILE B 2 250 ? 169.000 142.293 144.378 1.00 77.11  ? 272 ILE B N   1 
ATOM   2563 C CA  . ILE B 2 250 ? 168.104 141.211 144.799 1.00 77.11  ? 272 ILE B CA  1 
ATOM   2564 C C   . ILE B 2 250 ? 166.662 141.674 144.637 1.00 77.11  ? 272 ILE B C   1 
ATOM   2565 O O   . ILE B 2 250 ? 166.352 142.833 144.968 1.00 77.11  ? 272 ILE B O   1 
ATOM   2566 C CB  . ILE B 2 250 ? 168.401 140.815 146.247 1.00 77.11  ? 272 ILE B CB  1 
ATOM   2567 C CG1 . ILE B 2 250 ? 169.842 140.319 146.372 1.00 77.11  ? 272 ILE B CG1 1 
ATOM   2568 C CG2 . ILE B 2 250 ? 167.427 139.753 146.736 1.00 77.11  ? 272 ILE B CG2 1 
ATOM   2569 C CD1 . ILE B 2 250 ? 170.212 139.857 147.762 1.00 77.11  ? 272 ILE B CD1 1 
ATOM   2570 N N   . PRO B 2 251 ? 165.763 140.842 144.115 1.00 81.89  ? 273 PRO B N   1 
ATOM   2571 C CA  . PRO B 2 251 ? 164.363 141.255 143.949 1.00 81.89  ? 273 PRO B CA  1 
ATOM   2572 C C   . PRO B 2 251 ? 163.768 141.734 145.261 1.00 81.89  ? 273 PRO B C   1 
ATOM   2573 O O   . PRO B 2 251 ? 163.902 141.065 146.297 1.00 81.89  ? 273 PRO B O   1 
ATOM   2574 C CB  . PRO B 2 251 ? 163.675 139.974 143.458 1.00 81.89  ? 273 PRO B CB  1 
ATOM   2575 C CG  . PRO B 2 251 ? 164.754 139.227 142.760 1.00 81.89  ? 273 PRO B CG  1 
ATOM   2576 C CD  . PRO B 2 251 ? 166.025 139.523 143.510 1.00 81.89  ? 273 PRO B CD  1 
ATOM   2577 N N   . PRO B 2 252 ? 163.105 142.894 145.257 1.00 80.60  ? 274 PRO B N   1 
ATOM   2578 C CA  . PRO B 2 252 ? 162.590 143.452 146.519 1.00 80.60  ? 274 PRO B CA  1 
ATOM   2579 C C   . PRO B 2 252 ? 161.471 142.638 147.141 1.00 80.60  ? 274 PRO B C   1 
ATOM   2580 O O   . PRO B 2 252 ? 161.092 142.919 148.284 1.00 80.60  ? 274 PRO B O   1 
ATOM   2581 C CB  . PRO B 2 252 ? 162.095 144.849 146.112 1.00 80.60  ? 274 PRO B CB  1 
ATOM   2582 C CG  . PRO B 2 252 ? 162.725 145.122 144.777 1.00 80.60  ? 274 PRO B CG  1 
ATOM   2583 C CD  . PRO B 2 252 ? 162.864 143.791 144.117 1.00 80.60  ? 274 PRO B CD  1 
ATOM   2584 N N   . GLU B 2 253 ? 160.928 141.645 146.432 1.00 84.40  ? 275 GLU B N   1 
ATOM   2585 C CA  . GLU B 2 253 ? 159.829 140.859 146.983 1.00 84.40  ? 275 GLU B CA  1 
ATOM   2586 C C   . GLU B 2 253 ? 160.268 140.044 148.192 1.00 84.40  ? 275 GLU B C   1 
ATOM   2587 O O   . GLU B 2 253 ? 159.435 139.684 149.032 1.00 84.40  ? 275 GLU B O   1 
ATOM   2588 C CB  . GLU B 2 253 ? 159.250 139.942 145.905 1.00 84.40  ? 275 GLU B CB  1 
ATOM   2589 C CG  . GLU B 2 253 ? 158.439 140.665 144.840 1.00 84.40  ? 275 GLU B CG  1 
ATOM   2590 C CD  . GLU B 2 253 ? 159.308 141.384 143.826 1.00 84.40  ? 275 GLU B CD  1 
ATOM   2591 O OE1 . GLU B 2 253 ? 160.538 141.166 143.833 1.00 84.40  ? 275 GLU B OE1 1 
ATOM   2592 O OE2 . GLU B 2 253 ? 158.762 142.168 143.022 1.00 84.40  ? 275 GLU B OE2 1 
ATOM   2593 N N   . ASP B 2 254 ? 161.563 139.745 148.301 1.00 84.45  ? 276 ASP B N   1 
ATOM   2594 C CA  . ASP B 2 254 ? 162.064 138.975 149.431 1.00 84.45  ? 276 ASP B CA  1 
ATOM   2595 C C   . ASP B 2 254 ? 162.419 139.846 150.628 1.00 84.45  ? 276 ASP B C   1 
ATOM   2596 O O   . ASP B 2 254 ? 162.559 139.322 151.738 1.00 84.45  ? 276 ASP B O   1 
ATOM   2597 C CB  . ASP B 2 254 ? 163.287 138.159 149.008 1.00 84.45  ? 276 ASP B CB  1 
ATOM   2598 C CG  . ASP B 2 254 ? 163.000 137.249 147.831 1.00 84.45  ? 276 ASP B CG  1 
ATOM   2599 O OD1 . ASP B 2 254 ? 161.864 136.738 147.737 1.00 84.45  ? 276 ASP B OD1 1 
ATOM   2600 O OD2 . ASP B 2 254 ? 163.908 137.045 146.999 1.00 84.45  ? 276 ASP B OD2 1 
ATOM   2601 N N   . THR B 2 255 ? 162.568 141.154 150.431 1.00 75.76  ? 277 THR B N   1 
ATOM   2602 C CA  . THR B 2 255 ? 162.925 142.088 151.492 1.00 75.76  ? 277 THR B CA  1 
ATOM   2603 C C   . THR B 2 255 ? 161.857 143.164 151.654 1.00 75.76  ? 277 THR B C   1 
ATOM   2604 O O   . THR B 2 255 ? 162.159 144.354 151.762 1.00 75.76  ? 277 THR B O   1 
ATOM   2605 C CB  . THR B 2 255 ? 164.285 142.725 151.222 1.00 75.76  ? 277 THR B CB  1 
ATOM   2606 O OG1 . THR B 2 255 ? 164.214 143.516 150.030 1.00 75.76  ? 277 THR B OG1 1 
ATOM   2607 C CG2 . THR B 2 255 ? 165.348 141.654 151.047 1.00 75.76  ? 277 THR B CG2 1 
ATOM   2608 N N   . ALA B 2 256 ? 160.591 142.755 151.671 1.00 71.74  ? 278 ALA B N   1 
ATOM   2609 C CA  . ALA B 2 256 ? 159.471 143.680 151.767 1.00 71.74  ? 278 ALA B CA  1 
ATOM   2610 C C   . ALA B 2 256 ? 159.006 143.908 153.200 1.00 71.74  ? 278 ALA B C   1 
ATOM   2611 O O   . ALA B 2 256 ? 157.951 144.517 153.405 1.00 71.74  ? 278 ALA B O   1 
ATOM   2612 C CB  . ALA B 2 256 ? 158.301 143.180 150.917 1.00 71.74  ? 278 ALA B CB  1 
ATOM   2613 N N   . SER B 2 257 ? 159.758 143.436 154.191 1.00 66.14  ? 279 SER B N   1 
ATOM   2614 C CA  . SER B 2 257 ? 159.404 143.611 155.591 1.00 66.14  ? 279 SER B CA  1 
ATOM   2615 C C   . SER B 2 257 ? 160.655 143.930 156.396 1.00 66.14  ? 279 SER B C   1 
ATOM   2616 O O   . SER B 2 257 ? 161.781 143.854 155.897 1.00 66.14  ? 279 SER B O   1 
ATOM   2617 C CB  . SER B 2 257 ? 158.711 142.365 156.156 1.00 66.14  ? 279 SER B CB  1 
ATOM   2618 O OG  . SER B 2 257 ? 158.805 142.332 157.570 1.00 66.14  ? 279 SER B OG  1 
ATOM   2619 N N   . THR B 2 258 ? 160.446 144.290 157.659 1.00 62.84  ? 280 THR B N   1 
ATOM   2620 C CA  . THR B 2 258 ? 161.560 144.622 158.536 1.00 62.84  ? 280 THR B CA  1 
ATOM   2621 C C   . THR B 2 258 ? 162.270 143.354 158.999 1.00 62.84  ? 280 THR B C   1 
ATOM   2622 O O   . THR B 2 258 ? 161.628 142.350 159.322 1.00 62.84  ? 280 THR B O   1 
ATOM   2623 C CB  . THR B 2 258 ? 161.069 145.432 159.736 1.00 62.84  ? 280 THR B CB  1 
ATOM   2624 O OG1 . THR B 2 258 ? 162.150 145.635 160.655 1.00 62.84  ? 280 THR B OG1 1 
ATOM   2625 C CG2 . THR B 2 258 ? 159.922 144.721 160.442 1.00 62.84  ? 280 THR B CG2 1 
ATOM   2626 N N   . ARG B 2 259 ? 163.600 143.402 159.019 1.00 68.22  ? 281 ARG B N   1 
ATOM   2627 C CA  . ARG B 2 259 ? 164.412 142.264 159.426 1.00 68.22  ? 281 ARG B CA  1 
ATOM   2628 C C   . ARG B 2 259 ? 165.837 142.740 159.658 1.00 68.22  ? 281 ARG B C   1 
ATOM   2629 O O   . ARG B 2 259 ? 166.177 143.894 159.385 1.00 68.22  ? 281 ARG B O   1 
ATOM   2630 C CB  . ARG B 2 259 ? 164.384 141.145 158.379 1.00 68.22  ? 281 ARG B CB  1 
ATOM   2631 C CG  . ARG B 2 259 ? 164.959 141.548 157.033 1.00 68.22  ? 281 ARG B CG  1 
ATOM   2632 C CD  . ARG B 2 259 ? 164.244 140.842 155.896 1.00 68.22  ? 281 ARG B CD  1 
ATOM   2633 N NE  . ARG B 2 259 ? 164.266 139.392 156.056 1.00 68.22  ? 281 ARG B NE  1 
ATOM   2634 C CZ  . ARG B 2 259 ? 163.626 138.544 155.258 1.00 68.22  ? 281 ARG B CZ  1 
ATOM   2635 N NH1 . ARG B 2 259 ? 162.908 139.001 154.242 1.00 68.22  ? 281 ARG B NH1 1 
ATOM   2636 N NH2 . ARG B 2 259 ? 163.703 137.239 155.477 1.00 68.22  ? 281 ARG B NH2 1 
ATOM   2637 N N   . SER B 2 260 ? 166.669 141.830 160.170 1.00 70.42  ? 282 SER B N   1 
ATOM   2638 C CA  . SER B 2 260 ? 168.071 142.130 160.429 1.00 70.42  ? 282 SER B CA  1 
ATOM   2639 C C   . SER B 2 260 ? 169.007 141.022 159.959 1.00 70.42  ? 282 SER B C   1 
ATOM   2640 O O   . SER B 2 260 ? 170.150 140.957 160.426 1.00 70.42  ? 282 SER B O   1 
ATOM   2641 C CB  . SER B 2 260 ? 168.298 142.399 161.921 1.00 70.42  ? 282 SER B CB  1 
ATOM   2642 O OG  . SER B 2 260 ? 169.645 142.757 162.173 1.00 70.42  ? 282 SER B OG  1 
ATOM   2643 N N   . SER B 2 261 ? 168.561 140.154 159.055 1.00 70.67  ? 283 SER B N   1 
ATOM   2644 C CA  . SER B 2 261 ? 169.400 139.069 158.567 1.00 70.67  ? 283 SER B CA  1 
ATOM   2645 C C   . SER B 2 261 ? 168.886 138.613 157.211 1.00 70.67  ? 283 SER B C   1 
ATOM   2646 O O   . SER B 2 261 ? 167.686 138.676 156.934 1.00 70.67  ? 283 SER B O   1 
ATOM   2647 C CB  . SER B 2 261 ? 169.426 137.894 159.550 1.00 70.67  ? 283 SER B CB  1 
ATOM   2648 O OG  . SER B 2 261 ? 168.352 137.003 159.304 1.00 70.67  ? 283 SER B OG  1 
ATOM   2649 N N   . PHE B 2 262 ? 169.811 138.149 156.374 1.00 77.43  ? 284 PHE B N   1 
ATOM   2650 C CA  . PHE B 2 262 ? 169.473 137.662 155.045 1.00 77.43  ? 284 PHE B CA  1 
ATOM   2651 C C   . PHE B 2 262 ? 170.630 136.823 154.525 1.00 77.43  ? 284 PHE B C   1 
ATOM   2652 O O   . PHE B 2 262 ? 171.790 137.061 154.870 1.00 77.43  ? 284 PHE B O   1 
ATOM   2653 C CB  . PHE B 2 262 ? 169.169 138.814 154.081 1.00 77.43  ? 284 PHE B CB  1 
ATOM   2654 C CG  . PHE B 2 262 ? 168.574 138.371 152.778 1.00 77.43  ? 284 PHE B CG  1 
ATOM   2655 C CD1 . PHE B 2 262 ? 169.350 138.301 151.635 1.00 77.43  ? 284 PHE B CD1 1 
ATOM   2656 C CD2 . PHE B 2 262 ? 167.238 138.020 152.697 1.00 77.43  ? 284 PHE B CD2 1 
ATOM   2657 C CE1 . PHE B 2 262 ? 168.805 137.892 150.435 1.00 77.43  ? 284 PHE B CE1 1 
ATOM   2658 C CE2 . PHE B 2 262 ? 166.687 137.610 151.499 1.00 77.43  ? 284 PHE B CE2 1 
ATOM   2659 C CZ  . PHE B 2 262 ? 167.472 137.546 150.367 1.00 77.43  ? 284 PHE B CZ  1 
ATOM   2660 N N   . THR B 2 263 ? 170.300 135.839 153.691 1.00 81.16  ? 285 THR B N   1 
ATOM   2661 C CA  . THR B 2 263 ? 171.276 134.901 153.152 1.00 81.16  ? 285 THR B CA  1 
ATOM   2662 C C   . THR B 2 263 ? 171.298 134.997 151.634 1.00 81.16  ? 285 THR B C   1 
ATOM   2663 O O   . THR B 2 263 ? 170.247 134.930 150.988 1.00 81.16  ? 285 THR B O   1 
ATOM   2664 C CB  . THR B 2 263 ? 170.957 133.467 153.583 1.00 81.16  ? 285 THR B CB  1 
ATOM   2665 O OG1 . THR B 2 263 ? 170.924 133.393 155.013 1.00 81.16  ? 285 THR B OG1 1 
ATOM   2666 C CG2 . THR B 2 263 ? 172.010 132.507 153.055 1.00 81.16  ? 285 THR B CG2 1 
ATOM   2667 N N   . VAL B 2 264 ? 172.493 135.152 151.072 1.00 83.07  ? 286 VAL B N   1 
ATOM   2668 C CA  . VAL B 2 264 ? 172.673 135.173 149.628 1.00 83.07  ? 286 VAL B CA  1 
ATOM   2669 C C   . VAL B 2 264 ? 172.892 133.744 149.145 1.00 83.07  ? 286 VAL B C   1 
ATOM   2670 O O   . VAL B 2 264 ? 173.255 132.852 149.915 1.00 83.07  ? 286 VAL B O   1 
ATOM   2671 C CB  . VAL B 2 264 ? 173.844 136.094 149.224 1.00 83.07  ? 286 VAL B CB  1 
ATOM   2672 C CG1 . VAL B 2 264 ? 173.761 136.468 147.751 1.00 83.07  ? 286 VAL B CG1 1 
ATOM   2673 C CG2 . VAL B 2 264 ? 173.859 137.340 150.094 1.00 83.07  ? 286 VAL B CG2 1 
ATOM   2674 N N   . GLN B 2 265 ? 172.659 133.516 147.854 1.00 89.14  ? 287 GLN B N   1 
ATOM   2675 C CA  . GLN B 2 265 ? 172.748 132.178 147.289 1.00 89.14  ? 287 GLN B CA  1 
ATOM   2676 C C   . GLN B 2 265 ? 173.357 132.239 145.894 1.00 89.14  ? 287 GLN B C   1 
ATOM   2677 O O   . GLN B 2 265 ? 173.497 133.308 145.293 1.00 89.14  ? 287 GLN B O   1 
ATOM   2678 C CB  . GLN B 2 265 ? 171.371 131.506 147.236 1.00 89.14  ? 287 GLN B CB  1 
ATOM   2679 C CG  . GLN B 2 265 ? 170.995 130.761 148.503 1.00 89.14  ? 287 GLN B CG  1 
ATOM   2680 C CD  . GLN B 2 265 ? 171.585 129.368 148.554 1.00 89.14  ? 287 GLN B CD  1 
ATOM   2681 O OE1 . GLN B 2 265 ? 172.295 128.948 147.642 1.00 89.14  ? 287 GLN B OE1 1 
ATOM   2682 N NE2 . GLN B 2 265 ? 171.286 128.639 149.623 1.00 89.14  ? 287 GLN B NE2 1 
ATOM   2683 N N   . ASP B 2 266 ? 173.732 131.060 145.393 1.00 96.43  ? 288 ASP B N   1 
ATOM   2684 C CA  . ASP B 2 266 ? 174.155 130.857 144.007 1.00 96.43  ? 288 ASP B CA  1 
ATOM   2685 C C   . ASP B 2 266 ? 175.415 131.661 143.673 1.00 96.43  ? 288 ASP B C   1 
ATOM   2686 O O   . ASP B 2 266 ? 175.461 132.427 142.709 1.00 96.43  ? 288 ASP B O   1 
ATOM   2687 C CB  . ASP B 2 266 ? 173.014 131.191 143.039 1.00 96.43  ? 288 ASP B CB  1 
ATOM   2688 C CG  . ASP B 2 266 ? 171.680 130.627 143.494 1.00 96.43  ? 288 ASP B CG  1 
ATOM   2689 O OD1 . ASP B 2 266 ? 170.637 131.245 143.191 1.00 96.43  ? 288 ASP B OD1 1 
ATOM   2690 O OD2 . ASP B 2 266 ? 171.675 129.567 144.156 1.00 96.43  ? 288 ASP B OD2 1 
ATOM   2691 N N   . LEU B 2 267 ? 176.451 131.464 144.490 1.00 95.30  ? 289 LEU B N   1 
ATOM   2692 C CA  . LEU B 2 267 ? 177.774 132.052 144.262 1.00 95.30  ? 289 LEU B CA  1 
ATOM   2693 C C   . LEU B 2 267 ? 178.791 130.938 144.500 1.00 95.30  ? 289 LEU B C   1 
ATOM   2694 O O   . LEU B 2 267 ? 179.353 130.831 145.594 1.00 95.30  ? 289 LEU B O   1 
ATOM   2695 C CB  . LEU B 2 267 ? 178.006 133.238 145.194 1.00 95.30  ? 289 LEU B CB  1 
ATOM   2696 C CG  . LEU B 2 267 ? 176.929 134.326 145.235 1.00 95.30  ? 289 LEU B CG  1 
ATOM   2697 C CD1 . LEU B 2 267 ? 177.206 135.311 146.360 1.00 95.30  ? 289 LEU B CD1 1 
ATOM   2698 C CD2 . LEU B 2 267 ? 176.825 135.050 143.903 1.00 95.30  ? 289 LEU B CD2 1 
ATOM   2699 N N   . LYS B 2 268 ? 179.036 130.113 143.479 1.00 99.99  ? 290 LYS B N   1 
ATOM   2700 C CA  . LYS B 2 268 ? 179.741 128.862 143.741 1.00 99.99  ? 290 LYS B CA  1 
ATOM   2701 C C   . LYS B 2 268 ? 181.233 129.044 144.028 1.00 99.99  ? 290 LYS B C   1 
ATOM   2702 O O   . LYS B 2 268 ? 181.662 128.835 145.170 1.00 99.99  ? 290 LYS B O   1 
ATOM   2703 C CB  . LYS B 2 268 ? 179.553 127.876 142.578 1.00 99.99  ? 290 LYS B CB  1 
ATOM   2704 C CG  . LYS B 2 268 ? 178.219 127.952 141.839 1.00 99.99  ? 290 LYS B CG  1 
ATOM   2705 C CD  . LYS B 2 268 ? 177.016 127.863 142.766 1.00 99.99  ? 290 LYS B CD  1 
ATOM   2706 C CE  . LYS B 2 268 ? 175.724 128.025 141.981 1.00 99.99  ? 290 LYS B CE  1 
ATOM   2707 N NZ  . LYS B 2 268 ? 175.583 129.396 141.415 1.00 99.99  ? 290 LYS B NZ  1 
ATOM   2708 N N   . PRO B 2 269 ? 182.068 129.423 143.039 1.00 105.12 ? 291 PRO B N   1 
ATOM   2709 C CA  . PRO B 2 269 ? 183.518 129.283 143.238 1.00 105.12 ? 291 PRO B CA  1 
ATOM   2710 C C   . PRO B 2 269 ? 184.199 130.471 143.901 1.00 105.12 ? 291 PRO B C   1 
ATOM   2711 O O   . PRO B 2 269 ? 184.398 131.492 143.241 1.00 105.12 ? 291 PRO B O   1 
ATOM   2712 C CB  . PRO B 2 269 ? 184.031 129.092 141.806 1.00 105.12 ? 291 PRO B CB  1 
ATOM   2713 C CG  . PRO B 2 269 ? 182.986 129.799 140.921 1.00 105.12 ? 291 PRO B CG  1 
ATOM   2714 C CD  . PRO B 2 269 ? 181.796 130.159 141.790 1.00 105.12 ? 291 PRO B CD  1 
ATOM   2715 N N   . PHE B 2 270 ? 184.555 130.353 145.184 1.00 95.89  ? 292 PHE B N   1 
ATOM   2716 C CA  . PHE B 2 270 ? 185.624 131.115 145.833 1.00 95.89  ? 292 PHE B CA  1 
ATOM   2717 C C   . PHE B 2 270 ? 185.854 132.532 145.307 1.00 95.89  ? 292 PHE B C   1 
ATOM   2718 O O   . PHE B 2 270 ? 186.964 132.849 144.866 1.00 95.89  ? 292 PHE B O   1 
ATOM   2719 C CB  . PHE B 2 270 ? 186.936 130.330 145.743 1.00 95.89  ? 292 PHE B CB  1 
ATOM   2720 C CG  . PHE B 2 270 ? 187.971 130.759 146.746 1.00 95.89  ? 292 PHE B CG  1 
ATOM   2721 C CD1 . PHE B 2 270 ? 189.247 131.111 146.340 1.00 95.89  ? 292 PHE B CD1 1 
ATOM   2722 C CD2 . PHE B 2 270 ? 187.663 130.816 148.095 1.00 95.89  ? 292 PHE B CD2 1 
ATOM   2723 C CE1 . PHE B 2 270 ? 190.200 131.508 147.262 1.00 95.89  ? 292 PHE B CE1 1 
ATOM   2724 C CE2 . PHE B 2 270 ? 188.611 131.212 149.022 1.00 95.89  ? 292 PHE B CE2 1 
ATOM   2725 C CZ  . PHE B 2 270 ? 189.881 131.559 148.604 1.00 95.89  ? 292 PHE B CZ  1 
ATOM   2726 N N   . THR B 2 271 ? 184.838 133.391 145.330 1.00 92.72  ? 293 THR B N   1 
ATOM   2727 C CA  . THR B 2 271 ? 185.002 134.787 144.940 1.00 92.72  ? 293 THR B CA  1 
ATOM   2728 C C   . THR B 2 271 ? 184.551 135.723 146.053 1.00 92.72  ? 293 THR B C   1 
ATOM   2729 O O   . THR B 2 271 ? 183.780 135.344 146.938 1.00 92.72  ? 293 THR B O   1 
ATOM   2730 C CB  . THR B 2 271 ? 184.237 135.130 143.645 1.00 92.72  ? 293 THR B CB  1 
ATOM   2731 O OG1 . THR B 2 271 ? 182.836 134.894 143.824 1.00 92.72  ? 293 THR B OG1 1 
ATOM   2732 C CG2 . THR B 2 271 ? 184.772 134.354 142.452 1.00 92.72  ? 293 THR B CG2 1 
ATOM   2733 N N   . GLU B 2 272 ? 185.054 136.953 145.994 1.00 86.13  ? 294 GLU B N   1 
ATOM   2734 C CA  . GLU B 2 272 ? 184.747 137.995 146.963 1.00 86.13  ? 294 GLU B CA  1 
ATOM   2735 C C   . GLU B 2 272 ? 183.590 138.848 146.458 1.00 86.13  ? 294 GLU B C   1 
ATOM   2736 O O   . GLU B 2 272 ? 183.442 139.056 145.250 1.00 86.13  ? 294 GLU B O   1 
ATOM   2737 C CB  . GLU B 2 272 ? 185.978 138.870 147.214 1.00 86.13  ? 294 GLU B CB  1 
ATOM   2738 C CG  . GLU B 2 272 ? 185.773 139.993 148.217 1.00 86.13  ? 294 GLU B CG  1 
ATOM   2739 C CD  . GLU B 2 272 ? 186.917 140.988 148.218 1.00 86.13  ? 294 GLU B CD  1 
ATOM   2740 O OE1 . GLU B 2 272 ? 186.648 142.207 148.255 1.00 86.13  ? 294 GLU B OE1 1 
ATOM   2741 O OE2 . GLU B 2 272 ? 188.087 140.552 148.180 1.00 86.13  ? 294 GLU B OE2 1 
ATOM   2742 N N   . TYR B 2 273 ? 182.769 139.335 147.386 1.00 86.14  ? 295 TYR B N   1 
ATOM   2743 C CA  . TYR B 2 273 ? 181.615 140.157 147.055 1.00 86.14  ? 295 TYR B CA  1 
ATOM   2744 C C   . TYR B 2 273 ? 181.539 141.355 147.990 1.00 86.14  ? 295 TYR B C   1 
ATOM   2745 O O   . TYR B 2 273 ? 182.002 141.302 149.132 1.00 86.14  ? 295 TYR B O   1 
ATOM   2746 C CB  . TYR B 2 273 ? 180.313 139.352 147.147 1.00 86.14  ? 295 TYR B CB  1 
ATOM   2747 C CG  . TYR B 2 273 ? 180.241 138.207 146.169 1.00 86.14  ? 295 TYR B CG  1 
ATOM   2748 C CD1 . TYR B 2 273 ? 179.774 138.401 144.877 1.00 86.14  ? 295 TYR B CD1 1 
ATOM   2749 C CD2 . TYR B 2 273 ? 180.643 136.932 146.536 1.00 86.14  ? 295 TYR B CD2 1 
ATOM   2750 C CE1 . TYR B 2 273 ? 179.709 137.355 143.979 1.00 86.14  ? 295 TYR B CE1 1 
ATOM   2751 C CE2 . TYR B 2 273 ? 180.581 135.883 145.648 1.00 86.14  ? 295 TYR B CE2 1 
ATOM   2752 C CZ  . TYR B 2 273 ? 180.113 136.099 144.370 1.00 86.14  ? 295 TYR B CZ  1 
ATOM   2753 O OH  . TYR B 2 273 ? 180.052 135.051 143.481 1.00 86.14  ? 295 TYR B OH  1 
ATOM   2754 N N   . VAL B 2 274 ? 180.944 142.437 147.493 1.00 83.65  ? 296 VAL B N   1 
ATOM   2755 C CA  . VAL B 2 274 ? 180.687 143.638 148.279 1.00 83.65  ? 296 VAL B CA  1 
ATOM   2756 C C   . VAL B 2 274 ? 179.189 143.907 148.270 1.00 83.65  ? 296 VAL B C   1 
ATOM   2757 O O   . VAL B 2 274 ? 178.509 143.653 147.269 1.00 83.65  ? 296 VAL B O   1 
ATOM   2758 C CB  . VAL B 2 274 ? 181.471 144.853 147.743 1.00 83.65  ? 296 VAL B CB  1 
ATOM   2759 C CG1 . VAL B 2 274 ? 182.938 144.738 148.118 1.00 83.65  ? 296 VAL B CG1 1 
ATOM   2760 C CG2 . VAL B 2 274 ? 181.321 144.959 146.239 1.00 83.65  ? 296 VAL B CG2 1 
ATOM   2761 N N   . PHE B 2 275 ? 178.676 144.423 149.386 1.00 79.17  ? 297 PHE B N   1 
ATOM   2762 C CA  . PHE B 2 275 ? 177.243 144.576 149.587 1.00 79.17  ? 297 PHE B CA  1 
ATOM   2763 C C   . PHE B 2 275 ? 176.913 146.001 150.013 1.00 79.17  ? 297 PHE B C   1 
ATOM   2764 O O   . PHE B 2 275 ? 177.775 146.754 150.472 1.00 79.17  ? 297 PHE B O   1 
ATOM   2765 C CB  . PHE B 2 275 ? 176.718 143.588 150.638 1.00 79.17  ? 297 PHE B CB  1 
ATOM   2766 C CG  . PHE B 2 275 ? 176.867 142.147 150.244 1.00 79.17  ? 297 PHE B CG  1 
ATOM   2767 C CD1 . PHE B 2 275 ? 175.806 141.458 149.683 1.00 79.17  ? 297 PHE B CD1 1 
ATOM   2768 C CD2 . PHE B 2 275 ? 178.065 141.481 150.438 1.00 79.17  ? 297 PHE B CD2 1 
ATOM   2769 C CE1 . PHE B 2 275 ? 175.938 140.132 149.320 1.00 79.17  ? 297 PHE B CE1 1 
ATOM   2770 C CE2 . PHE B 2 275 ? 178.202 140.156 150.077 1.00 79.17  ? 297 PHE B CE2 1 
ATOM   2771 C CZ  . PHE B 2 275 ? 177.137 139.481 149.517 1.00 79.17  ? 297 PHE B CZ  1 
ATOM   2772 N N   . ARG B 2 276 ? 175.640 146.357 149.853 1.00 74.32  ? 298 ARG B N   1 
ATOM   2773 C CA  . ARG B 2 276 ? 175.123 147.649 150.279 1.00 74.32  ? 298 ARG B CA  1 
ATOM   2774 C C   . ARG B 2 276 ? 173.609 147.545 150.377 1.00 74.32  ? 298 ARG B C   1 
ATOM   2775 O O   . ARG B 2 276 ? 172.991 146.706 149.717 1.00 74.32  ? 298 ARG B O   1 
ATOM   2776 C CB  . ARG B 2 276 ? 175.527 148.770 149.315 1.00 74.32  ? 298 ARG B CB  1 
ATOM   2777 C CG  . ARG B 2 276 ? 174.923 148.645 147.929 1.00 74.32  ? 298 ARG B CG  1 
ATOM   2778 C CD  . ARG B 2 276 ? 175.337 149.806 147.041 1.00 74.32  ? 298 ARG B CD  1 
ATOM   2779 N NE  . ARG B 2 276 ? 174.735 149.721 145.714 1.00 74.32  ? 298 ARG B NE  1 
ATOM   2780 C CZ  . ARG B 2 276 ? 175.004 150.558 144.718 1.00 74.32  ? 298 ARG B CZ  1 
ATOM   2781 N NH1 . ARG B 2 276 ? 175.867 151.548 144.897 1.00 74.32  ? 298 ARG B NH1 1 
ATOM   2782 N NH2 . ARG B 2 276 ? 174.410 150.405 143.543 1.00 74.32  ? 298 ARG B NH2 1 
ATOM   2783 N N   . ILE B 2 277 ? 173.019 148.402 151.207 1.00 65.59  ? 299 ILE B N   1 
ATOM   2784 C CA  . ILE B 2 277 ? 171.590 148.331 151.491 1.00 65.59  ? 299 ILE B CA  1 
ATOM   2785 C C   . ILE B 2 277 ? 171.076 149.731 151.798 1.00 65.59  ? 299 ILE B C   1 
ATOM   2786 O O   . ILE B 2 277 ? 171.801 150.568 152.343 1.00 65.59  ? 299 ILE B O   1 
ATOM   2787 C CB  . ILE B 2 277 ? 171.304 147.354 152.654 1.00 65.59  ? 299 ILE B CB  1 
ATOM   2788 C CG1 . ILE B 2 277 ? 169.803 147.121 152.822 1.00 65.59  ? 299 ILE B CG1 1 
ATOM   2789 C CG2 . ILE B 2 277 ? 171.909 147.862 153.952 1.00 65.59  ? 299 ILE B CG2 1 
ATOM   2790 C CD1 . ILE B 2 277 ? 169.469 145.814 153.500 1.00 65.59  ? 299 ILE B CD1 1 
ATOM   2791 N N   . ARG B 2 278 ? 169.823 149.984 151.426 1.00 61.80  ? 300 ARG B N   1 
ATOM   2792 C CA  . ARG B 2 278 ? 169.106 151.200 151.781 1.00 61.80  ? 300 ARG B CA  1 
ATOM   2793 C C   . ARG B 2 278 ? 167.701 150.823 152.231 1.00 61.80  ? 300 ARG B C   1 
ATOM   2794 O O   . ARG B 2 278 ? 167.263 149.681 152.070 1.00 61.80  ? 300 ARG B O   1 
ATOM   2795 C CB  . ARG B 2 278 ? 169.053 152.189 150.610 1.00 61.80  ? 300 ARG B CB  1 
ATOM   2796 C CG  . ARG B 2 278 ? 168.384 151.643 149.363 1.00 61.80  ? 300 ARG B CG  1 
ATOM   2797 C CD  . ARG B 2 278 ? 168.213 152.730 148.316 1.00 61.80  ? 300 ARG B CD  1 
ATOM   2798 N NE  . ARG B 2 278 ? 167.633 152.215 147.081 1.00 61.80  ? 300 ARG B NE  1 
ATOM   2799 C CZ  . ARG B 2 278 ? 167.312 152.970 146.036 1.00 61.80  ? 300 ARG B CZ  1 
ATOM   2800 N NH1 . ARG B 2 278 ? 167.514 154.280 146.078 1.00 61.80  ? 300 ARG B NH1 1 
ATOM   2801 N NH2 . ARG B 2 278 ? 166.789 152.418 144.950 1.00 61.80  ? 300 ARG B NH2 1 
ATOM   2802 N N   . CYS B 2 279 ? 166.985 151.792 152.799 1.00 59.74  ? 301 CYS B N   1 
ATOM   2803 C CA  . CYS B 2 279 ? 165.668 151.510 153.352 1.00 59.74  ? 301 CYS B CA  1 
ATOM   2804 C C   . CYS B 2 279 ? 164.797 152.756 153.295 1.00 59.74  ? 301 CYS B C   1 
ATOM   2805 O O   . CYS B 2 279 ? 165.289 153.886 153.273 1.00 59.74  ? 301 CYS B O   1 
ATOM   2806 C CB  . CYS B 2 279 ? 165.766 151.004 154.796 1.00 59.74  ? 301 CYS B CB  1 
ATOM   2807 S SG  . CYS B 2 279 ? 166.505 152.182 155.947 1.00 59.74  ? 301 CYS B SG  1 
ATOM   2808 N N   . MET B 2 280 ? 163.488 152.527 153.275 1.00 55.84  ? 302 MET B N   1 
ATOM   2809 C CA  . MET B 2 280 ? 162.489 153.589 153.321 1.00 55.84  ? 302 MET B CA  1 
ATOM   2810 C C   . MET B 2 280 ? 161.227 153.009 153.950 1.00 55.84  ? 302 MET B C   1 
ATOM   2811 O O   . MET B 2 280 ? 161.218 151.863 154.409 1.00 55.84  ? 302 MET B O   1 
ATOM   2812 C CB  . MET B 2 280 ? 162.227 154.162 151.924 1.00 55.84  ? 302 MET B CB  1 
ATOM   2813 C CG  . MET B 2 280 ? 161.300 153.316 151.064 1.00 55.84  ? 302 MET B CG  1 
ATOM   2814 S SD  . MET B 2 280 ? 160.417 154.288 149.830 1.00 55.84  ? 302 MET B SD  1 
ATOM   2815 C CE  . MET B 2 280 ? 159.578 155.472 150.876 1.00 55.84  ? 302 MET B CE  1 
ATOM   2816 N N   . LYS B 2 281 ? 160.156 153.800 153.972 1.00 51.09  ? 303 LYS B N   1 
ATOM   2817 C CA  . LYS B 2 281 ? 158.890 153.317 154.505 1.00 51.09  ? 303 LYS B CA  1 
ATOM   2818 C C   . LYS B 2 281 ? 158.380 152.141 153.677 1.00 51.09  ? 303 LYS B C   1 
ATOM   2819 O O   . LYS B 2 281 ? 158.680 152.013 152.488 1.00 51.09  ? 303 LYS B O   1 
ATOM   2820 C CB  . LYS B 2 281 ? 157.856 154.442 154.525 1.00 51.09  ? 303 LYS B CB  1 
ATOM   2821 C CG  . LYS B 2 281 ? 156.721 154.224 155.511 1.00 51.09  ? 303 LYS B CG  1 
ATOM   2822 C CD  . LYS B 2 281 ? 155.807 155.433 155.582 1.00 51.09  ? 303 LYS B CD  1 
ATOM   2823 C CE  . LYS B 2 281 ? 154.685 155.211 156.580 1.00 51.09  ? 303 LYS B CE  1 
ATOM   2824 N NZ  . LYS B 2 281 ? 153.844 154.040 156.212 1.00 51.09  ? 303 LYS B NZ  1 
ATOM   2825 N N   . GLU B 2 282 ? 157.599 151.274 154.326 1.00 59.81  ? 304 GLU B N   1 
ATOM   2826 C CA  . GLU B 2 282 ? 157.170 150.032 153.688 1.00 59.81  ? 304 GLU B CA  1 
ATOM   2827 C C   . GLU B 2 282 ? 156.250 150.299 152.502 1.00 59.81  ? 304 GLU B C   1 
ATOM   2828 O O   . GLU B 2 282 ? 156.450 149.747 151.414 1.00 59.81  ? 304 GLU B O   1 
ATOM   2829 C CB  . GLU B 2 282 ? 156.478 149.130 154.710 1.00 59.81  ? 304 GLU B CB  1 
ATOM   2830 C CG  . GLU B 2 282 ? 155.554 148.094 154.093 1.00 59.81  ? 304 GLU B CG  1 
ATOM   2831 C CD  . GLU B 2 282 ? 154.950 147.162 155.124 1.00 59.81  ? 304 GLU B CD  1 
ATOM   2832 O OE1 . GLU B 2 282 ? 155.633 146.197 155.528 1.00 59.81  ? 304 GLU B OE1 1 
ATOM   2833 O OE2 . GLU B 2 282 ? 153.793 147.394 155.531 1.00 59.81  ? 304 GLU B OE2 1 
ATOM   2834 N N   . ASP B 2 283 ? 155.235 151.144 152.690 1.00 57.00  ? 305 ASP B N   1 
ATOM   2835 C CA  . ASP B 2 283 ? 154.252 151.390 151.641 1.00 57.00  ? 305 ASP B CA  1 
ATOM   2836 C C   . ASP B 2 283 ? 154.800 152.208 150.478 1.00 57.00  ? 305 ASP B C   1 
ATOM   2837 O O   . ASP B 2 283 ? 154.035 152.524 149.560 1.00 57.00  ? 305 ASP B O   1 
ATOM   2838 C CB  . ASP B 2 283 ? 153.024 152.088 152.228 1.00 57.00  ? 305 ASP B CB  1 
ATOM   2839 C CG  . ASP B 2 283 ? 153.379 153.341 153.003 1.00 57.00  ? 305 ASP B CG  1 
ATOM   2840 O OD1 . ASP B 2 283 ? 154.582 153.652 153.117 1.00 57.00  ? 305 ASP B OD1 1 
ATOM   2841 O OD2 . ASP B 2 283 ? 152.453 154.015 153.500 1.00 57.00  ? 305 ASP B OD2 1 
ATOM   2842 N N   . GLY B 2 284 ? 156.084 152.558 150.487 1.00 52.84  ? 306 GLY B N   1 
ATOM   2843 C CA  . GLY B 2 284 ? 156.685 153.306 149.405 1.00 52.84  ? 306 GLY B CA  1 
ATOM   2844 C C   . GLY B 2 284 ? 156.498 154.805 149.470 1.00 52.84  ? 306 GLY B C   1 
ATOM   2845 O O   . GLY B 2 284 ? 157.085 155.520 148.648 1.00 52.84  ? 306 GLY B O   1 
ATOM   2846 N N   . LYS B 2 285 ? 155.708 155.305 150.416 1.00 52.02  ? 307 LYS B N   1 
ATOM   2847 C CA  . LYS B 2 285 ? 155.491 156.737 150.568 1.00 52.02  ? 307 LYS B CA  1 
ATOM   2848 C C   . LYS B 2 285 ? 156.607 157.336 151.413 1.00 52.02  ? 307 LYS B C   1 
ATOM   2849 O O   . LYS B 2 285 ? 156.839 156.903 152.546 1.00 52.02  ? 307 LYS B O   1 
ATOM   2850 C CB  . LYS B 2 285 ? 154.133 157.011 151.215 1.00 52.02  ? 307 LYS B CB  1 
ATOM   2851 C CG  . LYS B 2 285 ? 153.008 156.137 150.690 1.00 52.02  ? 307 LYS B CG  1 
ATOM   2852 C CD  . LYS B 2 285 ? 152.516 156.623 149.339 1.00 52.02  ? 307 LYS B CD  1 
ATOM   2853 C CE  . LYS B 2 285 ? 151.659 157.868 149.486 1.00 52.02  ? 307 LYS B CE  1 
ATOM   2854 N NZ  . LYS B 2 285 ? 150.462 157.617 150.334 1.00 52.02  ? 307 LYS B NZ  1 
ATOM   2855 N N   . GLY B 2 286 ? 157.296 158.336 150.858 1.00 51.00  ? 308 GLY B N   1 
ATOM   2856 C CA  . GLY B 2 286 ? 158.404 158.985 151.529 1.00 51.00  ? 308 GLY B CA  1 
ATOM   2857 C C   . GLY B 2 286 ? 159.607 159.107 150.606 1.00 51.00  ? 308 GLY B C   1 
ATOM   2858 O O   . GLY B 2 286 ? 159.462 159.349 149.403 1.00 51.00  ? 308 GLY B O   1 
ATOM   2859 N N   . TYR B 2 287 ? 160.795 158.939 151.181 1.00 56.72  ? 309 TYR B N   1 
ATOM   2860 C CA  . TYR B 2 287 ? 162.042 159.052 150.442 1.00 56.72  ? 309 TYR B CA  1 
ATOM   2861 C C   . TYR B 2 287 ? 162.978 157.920 150.837 1.00 56.72  ? 309 TYR B C   1 
ATOM   2862 O O   . TYR B 2 287 ? 163.035 157.529 152.006 1.00 56.72  ? 309 TYR B O   1 
ATOM   2863 C CB  . TYR B 2 287 ? 162.719 160.406 150.696 1.00 56.72  ? 309 TYR B CB  1 
ATOM   2864 C CG  . TYR B 2 287 ? 161.836 161.600 150.404 1.00 56.72  ? 309 TYR B CG  1 
ATOM   2865 C CD1 . TYR B 2 287 ? 161.862 162.220 149.163 1.00 56.72  ? 309 TYR B CD1 1 
ATOM   2866 C CD2 . TYR B 2 287 ? 160.977 162.107 151.371 1.00 56.72  ? 309 TYR B CD2 1 
ATOM   2867 C CE1 . TYR B 2 287 ? 161.056 163.310 148.892 1.00 56.72  ? 309 TYR B CE1 1 
ATOM   2868 C CE2 . TYR B 2 287 ? 160.168 163.196 151.108 1.00 56.72  ? 309 TYR B CE2 1 
ATOM   2869 C CZ  . TYR B 2 287 ? 160.212 163.793 149.867 1.00 56.72  ? 309 TYR B CZ  1 
ATOM   2870 O OH  . TYR B 2 287 ? 159.408 164.878 149.602 1.00 56.72  ? 309 TYR B OH  1 
ATOM   2871 N N   . TRP B 2 288 ? 163.708 157.396 149.856 1.00 57.75  ? 310 TRP B N   1 
ATOM   2872 C CA  . TRP B 2 288 ? 164.683 156.351 150.127 1.00 57.75  ? 310 TRP B CA  1 
ATOM   2873 C C   . TRP B 2 288 ? 165.905 156.934 150.824 1.00 57.75  ? 310 TRP B C   1 
ATOM   2874 O O   . TRP B 2 288 ? 166.342 158.047 150.521 1.00 57.75  ? 310 TRP B O   1 
ATOM   2875 C CB  . TRP B 2 288 ? 165.102 155.661 148.829 1.00 57.75  ? 310 TRP B CB  1 
ATOM   2876 C CG  . TRP B 2 288 ? 164.086 154.697 148.302 1.00 57.75  ? 310 TRP B CG  1 
ATOM   2877 C CD1 . TRP B 2 288 ? 163.183 154.922 147.305 1.00 57.75  ? 310 TRP B CD1 1 
ATOM   2878 C CD2 . TRP B 2 288 ? 163.872 153.350 148.740 1.00 57.75  ? 310 TRP B CD2 1 
ATOM   2879 N NE1 . TRP B 2 288 ? 162.418 153.801 147.097 1.00 57.75  ? 310 TRP B NE1 1 
ATOM   2880 C CE2 . TRP B 2 288 ? 162.822 152.822 147.965 1.00 57.75  ? 310 TRP B CE2 1 
ATOM   2881 C CE3 . TRP B 2 288 ? 164.465 152.541 149.712 1.00 57.75  ? 310 TRP B CE3 1 
ATOM   2882 C CZ2 . TRP B 2 288 ? 162.351 151.523 148.134 1.00 57.75  ? 310 TRP B CZ2 1 
ATOM   2883 C CZ3 . TRP B 2 288 ? 163.997 151.253 149.878 1.00 57.75  ? 310 TRP B CZ3 1 
ATOM   2884 C CH2 . TRP B 2 288 ? 162.949 150.757 149.094 1.00 57.75  ? 310 TRP B CH2 1 
ATOM   2885 N N   . SER B 2 289 ? 166.459 156.173 151.764 1.00 62.26  ? 311 SER B N   1 
ATOM   2886 C CA  . SER B 2 289 ? 167.643 156.612 152.483 1.00 62.26  ? 311 SER B CA  1 
ATOM   2887 C C   . SER B 2 289 ? 168.880 156.477 151.597 1.00 62.26  ? 311 SER B C   1 
ATOM   2888 O O   . SER B 2 289 ? 168.822 156.000 150.460 1.00 62.26  ? 311 SER B O   1 
ATOM   2889 C CB  . SER B 2 289 ? 167.811 155.811 153.770 1.00 62.26  ? 311 SER B CB  1 
ATOM   2890 O OG  . SER B 2 289 ? 168.991 156.196 154.451 1.00 62.26  ? 311 SER B OG  1 
ATOM   2891 N N   . ASP B 2 290 ? 170.018 156.905 152.132 1.00 69.68  ? 312 ASP B N   1 
ATOM   2892 C CA  . ASP B 2 290 ? 171.277 156.784 151.418 1.00 69.68  ? 312 ASP B CA  1 
ATOM   2893 C C   . ASP B 2 290 ? 171.799 155.352 151.493 1.00 69.68  ? 312 ASP B C   1 
ATOM   2894 O O   . ASP B 2 290 ? 171.326 154.528 152.280 1.00 69.68  ? 312 ASP B O   1 
ATOM   2895 C CB  . ASP B 2 290 ? 172.316 157.750 151.986 1.00 69.68  ? 312 ASP B CB  1 
ATOM   2896 C CG  . ASP B 2 290 ? 172.005 159.196 151.662 1.00 69.68  ? 312 ASP B CG  1 
ATOM   2897 O OD1 . ASP B 2 290 ? 171.072 159.756 152.274 1.00 69.68  ? 312 ASP B OD1 1 
ATOM   2898 O OD2 . ASP B 2 290 ? 172.695 159.774 150.796 1.00 69.68  ? 312 ASP B OD2 1 
ATOM   2899 N N   . TRP B 2 291 ? 172.788 155.063 150.654 1.00 66.73  ? 313 TRP B N   1 
ATOM   2900 C CA  . TRP B 2 291 ? 173.414 153.750 150.650 1.00 66.73  ? 313 TRP B CA  1 
ATOM   2901 C C   . TRP B 2 291 ? 174.346 153.605 151.844 1.00 66.73  ? 313 TRP B C   1 
ATOM   2902 O O   . TRP B 2 291 ? 175.099 154.525 152.179 1.00 66.73  ? 313 TRP B O   1 
ATOM   2903 C CB  . TRP B 2 291 ? 174.188 153.528 149.351 1.00 66.73  ? 313 TRP B CB  1 
ATOM   2904 C CG  . TRP B 2 291 ? 173.310 153.337 148.156 1.00 66.73  ? 313 TRP B CG  1 
ATOM   2905 C CD1 . TRP B 2 291 ? 173.124 154.213 147.129 1.00 66.73  ? 313 TRP B CD1 1 
ATOM   2906 C CD2 . TRP B 2 291 ? 172.495 152.196 147.863 1.00 66.73  ? 313 TRP B CD2 1 
ATOM   2907 N NE1 . TRP B 2 291 ? 172.244 153.689 146.213 1.00 66.73  ? 313 TRP B NE1 1 
ATOM   2908 C CE2 . TRP B 2 291 ? 171.844 152.451 146.641 1.00 66.73  ? 313 TRP B CE2 1 
ATOM   2909 C CE3 . TRP B 2 291 ? 172.253 150.984 148.516 1.00 66.73  ? 313 TRP B CE3 1 
ATOM   2910 C CZ2 . TRP B 2 291 ? 170.967 151.540 146.059 1.00 66.73  ? 313 TRP B CZ2 1 
ATOM   2911 C CZ3 . TRP B 2 291 ? 171.383 150.081 147.936 1.00 66.73  ? 313 TRP B CZ3 1 
ATOM   2912 C CH2 . TRP B 2 291 ? 170.750 150.363 146.720 1.00 66.73  ? 313 TRP B CH2 1 
ATOM   2913 N N   . SER B 2 292 ? 174.291 152.443 152.488 1.00 73.28  ? 314 SER B N   1 
ATOM   2914 C CA  . SER B 2 292 ? 175.153 152.177 153.626 1.00 73.28  ? 314 SER B CA  1 
ATOM   2915 C C   . SER B 2 292 ? 176.589 151.936 153.162 1.00 73.28  ? 314 SER B C   1 
ATOM   2916 O O   . SER B 2 292 ? 176.890 151.888 151.966 1.00 73.28  ? 314 SER B O   1 
ATOM   2917 C CB  . SER B 2 292 ? 174.642 150.973 154.413 1.00 73.28  ? 314 SER B CB  1 
ATOM   2918 O OG  . SER B 2 292 ? 174.301 149.911 153.541 1.00 73.28  ? 314 SER B OG  1 
ATOM   2919 N N   . GLU B 2 293 ? 177.483 151.782 154.134 1.00 83.15  ? 315 GLU B N   1 
ATOM   2920 C CA  . GLU B 2 293 ? 178.881 151.521 153.827 1.00 83.15  ? 315 GLU B CA  1 
ATOM   2921 C C   . GLU B 2 293 ? 179.040 150.141 153.201 1.00 83.15  ? 315 GLU B C   1 
ATOM   2922 O O   . GLU B 2 293 ? 178.379 149.179 153.599 1.00 83.15  ? 315 GLU B O   1 
ATOM   2923 C CB  . GLU B 2 293 ? 179.732 151.627 155.093 1.00 83.15  ? 315 GLU B CB  1 
ATOM   2924 C CG  . GLU B 2 293 ? 179.653 152.978 155.792 1.00 83.15  ? 315 GLU B CG  1 
ATOM   2925 C CD  . GLU B 2 293 ? 180.482 154.055 155.112 1.00 83.15  ? 315 GLU B CD  1 
ATOM   2926 O OE1 . GLU B 2 293 ? 181.004 153.811 154.003 1.00 83.15  ? 315 GLU B OE1 1 
ATOM   2927 O OE2 . GLU B 2 293 ? 180.611 155.154 155.691 1.00 83.15  ? 315 GLU B OE2 1 
ATOM   2928 N N   . GLU B 2 294 ? 179.925 150.050 152.212 1.00 87.67  ? 316 GLU B N   1 
ATOM   2929 C CA  . GLU B 2 294 ? 180.141 148.790 151.514 1.00 87.67  ? 316 GLU B CA  1 
ATOM   2930 C C   . GLU B 2 294 ? 180.908 147.816 152.400 1.00 87.67  ? 316 GLU B C   1 
ATOM   2931 O O   . GLU B 2 294 ? 181.956 148.157 152.955 1.00 87.67  ? 316 GLU B O   1 
ATOM   2932 C CB  . GLU B 2 294 ? 180.899 149.033 150.210 1.00 87.67  ? 316 GLU B CB  1 
ATOM   2933 C CG  . GLU B 2 294 ? 180.089 149.757 149.148 1.00 87.67  ? 316 GLU B CG  1 
ATOM   2934 C CD  . GLU B 2 294 ? 180.877 149.992 147.874 1.00 87.67  ? 316 GLU B CD  1 
ATOM   2935 O OE1 . GLU B 2 294 ? 180.557 150.954 147.144 1.00 87.67  ? 316 GLU B OE1 1 
ATOM   2936 O OE2 . GLU B 2 294 ? 181.818 149.217 147.602 1.00 87.67  ? 316 GLU B OE2 1 
ATOM   2937 N N   . ALA B 2 295 ? 180.381 146.602 152.531 1.00 87.97  ? 317 ALA B N   1 
ATOM   2938 C CA  . ALA B 2 295 ? 181.007 145.547 153.315 1.00 87.97  ? 317 ALA B CA  1 
ATOM   2939 C C   . ALA B 2 295 ? 181.399 144.391 152.405 1.00 87.97  ? 317 ALA B C   1 
ATOM   2940 O O   . ALA B 2 295 ? 180.639 144.010 151.509 1.00 87.97  ? 317 ALA B O   1 
ATOM   2941 C CB  . ALA B 2 295 ? 180.070 145.050 154.418 1.00 87.97  ? 317 ALA B CB  1 
ATOM   2942 N N   . SER B 2 296 ? 182.581 143.834 152.642 1.00 90.98  ? 318 SER B N   1 
ATOM   2943 C CA  . SER B 2 296 ? 183.123 142.764 151.819 1.00 90.98  ? 318 SER B CA  1 
ATOM   2944 C C   . SER B 2 296 ? 182.984 141.416 152.516 1.00 90.98  ? 318 SER B C   1 
ATOM   2945 O O   . SER B 2 296 ? 182.829 141.330 153.737 1.00 90.98  ? 318 SER B O   1 
ATOM   2946 C CB  . SER B 2 296 ? 184.593 143.031 151.486 1.00 90.98  ? 318 SER B CB  1 
ATOM   2947 O OG  . SER B 2 296 ? 185.444 142.522 152.498 1.00 90.98  ? 318 SER B OG  1 
ATOM   2948 N N   . GLY B 2 297 ? 183.043 140.356 151.716 1.00 89.82  ? 319 GLY B N   1 
ATOM   2949 C CA  . GLY B 2 297 ? 182.960 139.006 152.239 1.00 89.82  ? 319 GLY B CA  1 
ATOM   2950 C C   . GLY B 2 297 ? 183.337 138.000 151.179 1.00 89.82  ? 319 GLY B C   1 
ATOM   2951 O O   . GLY B 2 297 ? 182.970 138.141 150.009 1.00 89.82  ? 319 GLY B O   1 
ATOM   2952 N N   . ILE B 2 298 ? 184.076 136.974 151.594 1.00 85.59  ? 320 ILE B N   1 
ATOM   2953 C CA  . ILE B 2 298 ? 184.565 135.930 150.700 1.00 85.59  ? 320 ILE B CA  1 
ATOM   2954 C C   . ILE B 2 298 ? 183.795 134.651 150.990 1.00 85.59  ? 320 ILE B C   1 
ATOM   2955 O O   . ILE B 2 298 ? 183.607 134.283 152.155 1.00 85.59  ? 320 ILE B O   1 
ATOM   2956 C CB  . ILE B 2 298 ? 186.079 135.712 150.862 1.00 85.59  ? 320 ILE B CB  1 
ATOM   2957 C CG1 . ILE B 2 298 ? 186.832 137.027 150.657 1.00 85.59  ? 320 ILE B CG1 1 
ATOM   2958 C CG2 . ILE B 2 298 ? 186.577 134.660 149.884 1.00 85.59  ? 320 ILE B CG2 1 
ATOM   2959 C CD1 . ILE B 2 298 ? 188.329 136.906 150.826 1.00 85.59  ? 320 ILE B CD1 1 
ATOM   2960 N N   . THR B 2 299 ? 183.354 133.974 149.932 1.00 90.05  ? 321 THR B N   1 
ATOM   2961 C CA  . THR B 2 299 ? 182.574 132.758 150.081 1.00 90.05  ? 321 THR B CA  1 
ATOM   2962 C C   . THR B 2 299 ? 183.456 131.602 150.548 1.00 90.05  ? 321 THR B C   1 
ATOM   2963 O O   . THR B 2 299 ? 184.684 131.698 150.608 1.00 90.05  ? 321 THR B O   1 
ATOM   2964 C CB  . THR B 2 299 ? 181.887 132.393 148.766 1.00 90.05  ? 321 THR B CB  1 
ATOM   2965 O OG1 . THR B 2 299 ? 182.877 132.100 147.773 1.00 90.05  ? 321 THR B OG1 1 
ATOM   2966 C CG2 . THR B 2 299 ? 181.019 133.541 148.285 1.00 90.05  ? 321 THR B CG2 1 
ATOM   2967 N N   . TYR B 2 300 ? 182.803 130.494 150.883 1.00 99.40  ? 322 TYR B N   1 
ATOM   2968 C CA  . TYR B 2 300 ? 183.494 129.299 151.337 1.00 99.40  ? 322 TYR B CA  1 
ATOM   2969 C C   . TYR B 2 300 ? 184.069 128.531 150.151 1.00 99.40  ? 322 TYR B C   1 
ATOM   2970 O O   . TYR B 2 300 ? 183.588 128.629 149.019 1.00 99.40  ? 322 TYR B O   1 
ATOM   2971 C CB  . TYR B 2 300 ? 182.542 128.411 152.140 1.00 99.40  ? 322 TYR B CB  1 
ATOM   2972 C CG  . TYR B 2 300 ? 183.177 127.166 152.717 1.00 99.40  ? 322 TYR B CG  1 
ATOM   2973 C CD1 . TYR B 2 300 ? 182.708 125.905 152.377 1.00 99.40  ? 322 TYR B CD1 1 
ATOM   2974 C CD2 . TYR B 2 300 ? 184.243 127.252 153.602 1.00 99.40  ? 322 TYR B CD2 1 
ATOM   2975 C CE1 . TYR B 2 300 ? 183.282 124.763 152.902 1.00 99.40  ? 322 TYR B CE1 1 
ATOM   2976 C CE2 . TYR B 2 300 ? 184.825 126.115 154.131 1.00 99.40  ? 322 TYR B CE2 1 
ATOM   2977 C CZ  . TYR B 2 300 ? 184.339 124.874 153.778 1.00 99.40  ? 322 TYR B CZ  1 
ATOM   2978 O OH  . TYR B 2 300 ? 184.914 123.739 154.302 1.00 99.40  ? 322 TYR B OH  1 
ATOM   2979 N N   . GLU B 2 301 ? 185.119 127.764 150.423 1.00 98.40  ? 323 GLU B N   1 
ATOM   2980 C CA  . GLU B 2 301 ? 185.782 126.981 149.387 1.00 98.40  ? 323 GLU B CA  1 
ATOM   2981 C C   . GLU B 2 301 ? 185.638 125.486 149.647 1.00 98.40  ? 323 GLU B C   1 
ATOM   2982 O O   . GLU B 2 301 ? 185.287 124.721 148.748 1.00 98.40  ? 323 GLU B O   1 
ATOM   2983 C CB  . GLU B 2 301 ? 187.262 127.360 149.295 1.00 98.40  ? 323 GLU B CB  1 
ATOM   2984 C CG  . GLU B 2 301 ? 188.091 126.428 148.428 1.00 98.40  ? 323 GLU B CG  1 
ATOM   2985 C CD  . GLU B 2 301 ? 189.487 126.962 148.173 1.00 98.40  ? 323 GLU B CD  1 
ATOM   2986 O OE1 . GLU B 2 301 ? 189.833 127.187 146.994 1.00 98.40  ? 323 GLU B OE1 1 
ATOM   2987 O OE2 . GLU B 2 301 ? 190.237 127.158 149.152 1.00 98.40  ? 323 GLU B OE2 1 
ATOM   2988 N N   . THR C 3 208 ? 158.100 164.644 209.736 1.00 63.04  ? 252 THR C N   1 
ATOM   2989 C CA  . THR C 3 208 ? 159.516 164.520 209.413 1.00 63.04  ? 252 THR C CA  1 
ATOM   2990 C C   . THR C 3 208 ? 160.169 163.399 210.219 1.00 63.04  ? 252 THR C C   1 
ATOM   2991 O O   . THR C 3 208 ? 159.828 163.173 211.380 1.00 63.04  ? 252 THR C O   1 
ATOM   2992 C CB  . THR C 3 208 ? 160.266 165.846 209.661 1.00 63.04  ? 252 THR C CB  1 
ATOM   2993 O OG1 . THR C 3 208 ? 161.642 165.699 209.291 1.00 63.04  ? 252 THR C OG1 1 
ATOM   2994 C CG2 . THR C 3 208 ? 160.168 166.264 211.121 1.00 63.04  ? 252 THR C CG2 1 
ATOM   2995 N N   . LYS C 3 209 ? 161.100 162.685 209.590 1.00 57.21  ? 253 LYS C N   1 
ATOM   2996 C CA  . LYS C 3 209 ? 161.777 161.564 210.225 1.00 57.21  ? 253 LYS C CA  1 
ATOM   2997 C C   . LYS C 3 209 ? 163.294 161.662 210.203 1.00 57.21  ? 253 LYS C C   1 
ATOM   2998 O O   . LYS C 3 209 ? 163.942 161.095 211.084 1.00 57.21  ? 253 LYS C O   1 
ATOM   2999 C CB  . LYS C 3 209 ? 161.362 160.241 209.562 1.00 57.21  ? 253 LYS C CB  1 
ATOM   3000 C CG  . LYS C 3 209 ? 160.354 159.429 210.360 1.00 57.21  ? 253 LYS C CG  1 
ATOM   3001 C CD  . LYS C 3 209 ? 159.006 160.125 210.429 1.00 57.21  ? 253 LYS C CD  1 
ATOM   3002 C CE  . LYS C 3 209 ? 157.982 159.274 211.160 1.00 57.21  ? 253 LYS C CE  1 
ATOM   3003 N NZ  . LYS C 3 209 ? 156.644 159.926 211.186 1.00 57.21  ? 253 LYS C NZ  1 
ATOM   3004 N N   . VAL C 3 210 ? 163.877 162.356 209.229 1.00 53.69  ? 254 VAL C N   1 
ATOM   3005 C CA  . VAL C 3 210 ? 165.323 162.459 209.086 1.00 53.69  ? 254 VAL C CA  1 
ATOM   3006 C C   . VAL C 3 210 ? 165.739 163.905 209.316 1.00 53.69  ? 254 VAL C C   1 
ATOM   3007 O O   . VAL C 3 210 ? 165.044 164.835 208.892 1.00 53.69  ? 254 VAL C O   1 
ATOM   3008 C CB  . VAL C 3 210 ? 165.790 161.971 207.699 1.00 53.69  ? 254 VAL C CB  1 
ATOM   3009 C CG1 . VAL C 3 210 ? 167.301 161.811 207.669 1.00 53.69  ? 254 VAL C CG1 1 
ATOM   3010 C CG2 . VAL C 3 210 ? 165.106 160.662 207.344 1.00 53.69  ? 254 VAL C CG2 1 
ATOM   3011 N N   . PHE C 3 211 ? 166.873 164.091 209.990 1.00 52.55  ? 255 PHE C N   1 
ATOM   3012 C CA  . PHE C 3 211 ? 167.414 165.409 210.273 1.00 52.55  ? 255 PHE C CA  1 
ATOM   3013 C C   . PHE C 3 211 ? 168.908 165.428 209.982 1.00 52.55  ? 255 PHE C C   1 
ATOM   3014 O O   . PHE C 3 211 ? 169.605 164.443 210.254 1.00 52.55  ? 255 PHE C O   1 
ATOM   3015 C CB  . PHE C 3 211 ? 167.172 165.804 211.736 1.00 52.55  ? 255 PHE C CB  1 
ATOM   3016 C CG  . PHE C 3 211 ? 165.756 165.616 212.189 1.00 52.55  ? 255 PHE C CG  1 
ATOM   3017 C CD1 . PHE C 3 211 ? 164.802 166.585 211.938 1.00 52.55  ? 255 PHE C CD1 1 
ATOM   3018 C CD2 . PHE C 3 211 ? 165.379 164.472 212.869 1.00 52.55  ? 255 PHE C CD2 1 
ATOM   3019 C CE1 . PHE C 3 211 ? 163.499 166.417 212.356 1.00 52.55  ? 255 PHE C CE1 1 
ATOM   3020 C CE2 . PHE C 3 211 ? 164.077 164.297 213.289 1.00 52.55  ? 255 PHE C CE2 1 
ATOM   3021 C CZ  . PHE C 3 211 ? 163.135 165.271 213.031 1.00 52.55  ? 255 PHE C CZ  1 
ATOM   3022 N N   . PRO C 3 212 ? 169.435 166.532 209.429 1.00 56.66  ? 256 PRO C N   1 
ATOM   3023 C CA  . PRO C 3 212 ? 168.687 167.727 209.029 1.00 56.66  ? 256 PRO C CA  1 
ATOM   3024 C C   . PRO C 3 212 ? 168.043 167.578 207.655 1.00 56.66  ? 256 PRO C C   1 
ATOM   3025 O O   . PRO C 3 212 ? 168.227 166.551 207.002 1.00 56.66  ? 256 PRO C O   1 
ATOM   3026 C CB  . PRO C 3 212 ? 169.761 168.812 209.010 1.00 56.66  ? 256 PRO C CB  1 
ATOM   3027 C CG  . PRO C 3 212 ? 170.997 168.082 208.627 1.00 56.66  ? 256 PRO C CG  1 
ATOM   3028 C CD  . PRO C 3 212 ? 170.885 166.706 209.235 1.00 56.66  ? 256 PRO C CD  1 
ATOM   3029 N N   . GLN C 3 213 ? 167.300 168.594 207.222 1.00 60.39  ? 257 GLN C N   1 
ATOM   3030 C CA  . GLN C 3 213 ? 166.575 168.558 205.958 1.00 60.39  ? 257 GLN C CA  1 
ATOM   3031 C C   . GLN C 3 213 ? 167.001 169.738 205.098 1.00 60.39  ? 257 GLN C C   1 
ATOM   3032 O O   . GLN C 3 213 ? 166.883 170.893 205.521 1.00 60.39  ? 257 GLN C O   1 
ATOM   3033 C CB  . GLN C 3 213 ? 165.064 168.585 206.195 1.00 60.39  ? 257 GLN C CB  1 
ATOM   3034 C CG  . GLN C 3 213 ? 164.540 167.375 206.945 1.00 60.39  ? 257 GLN C CG  1 
ATOM   3035 C CD  . GLN C 3 213 ? 163.040 167.414 207.140 1.00 60.39  ? 257 GLN C CD  1 
ATOM   3036 O OE1 . GLN C 3 213 ? 162.378 166.377 207.157 1.00 60.39  ? 257 GLN C OE1 1 
ATOM   3037 N NE2 . GLN C 3 213 ? 162.494 168.615 207.290 1.00 60.39  ? 257 GLN C NE2 1 
ATOM   3038 N N   . ASP C 3 214 ? 167.495 169.441 203.894 1.00 56.04  ? 258 ASP C N   1 
ATOM   3039 C CA  . ASP C 3 214 ? 167.857 170.459 202.905 1.00 56.04  ? 258 ASP C CA  1 
ATOM   3040 C C   . ASP C 3 214 ? 168.888 171.439 203.457 1.00 56.04  ? 258 ASP C C   1 
ATOM   3041 O O   . ASP C 3 214 ? 168.799 172.649 203.241 1.00 56.04  ? 258 ASP C O   1 
ATOM   3042 C CB  . ASP C 3 214 ? 166.618 171.201 202.402 1.00 56.04  ? 258 ASP C CB  1 
ATOM   3043 C CG  . ASP C 3 214 ? 165.712 170.320 201.566 1.00 56.04  ? 258 ASP C CG  1 
ATOM   3044 O OD1 . ASP C 3 214 ? 166.226 169.385 200.917 1.00 56.04  ? 258 ASP C OD1 1 
ATOM   3045 O OD2 . ASP C 3 214 ? 164.487 170.560 201.559 1.00 56.04  ? 258 ASP C OD2 1 
ATOM   3046 N N   . LYS C 3 215 ? 169.876 170.916 204.175 1.00 53.36  ? 259 LYS C N   1 
ATOM   3047 C CA  . LYS C 3 215 ? 170.930 171.752 204.729 1.00 53.36  ? 259 LYS C CA  1 
ATOM   3048 C C   . LYS C 3 215 ? 172.027 171.976 203.698 1.00 53.36  ? 259 LYS C C   1 
ATOM   3049 O O   . LYS C 3 215 ? 172.394 171.065 202.951 1.00 53.36  ? 259 LYS C O   1 
ATOM   3050 C CB  . LYS C 3 215 ? 171.517 171.110 205.986 1.00 53.36  ? 259 LYS C CB  1 
ATOM   3051 C CG  . LYS C 3 215 ? 172.506 171.993 206.729 1.00 53.36  ? 259 LYS C CG  1 
ATOM   3052 C CD  . LYS C 3 215 ? 172.983 171.333 208.010 1.00 53.36  ? 259 LYS C CD  1 
ATOM   3053 C CE  . LYS C 3 215 ? 173.923 172.243 208.783 1.00 53.36  ? 259 LYS C CE  1 
ATOM   3054 N NZ  . LYS C 3 215 ? 175.137 172.587 207.993 1.00 53.36  ? 259 LYS C NZ  1 
ATOM   3055 N N   . VAL C 3 216 ? 172.545 173.198 203.657 1.00 55.89  ? 260 VAL C N   1 
ATOM   3056 C CA  . VAL C 3 216 ? 173.640 173.561 202.766 1.00 55.89  ? 260 VAL C CA  1 
ATOM   3057 C C   . VAL C 3 216 ? 174.940 173.468 203.548 1.00 55.89  ? 260 VAL C C   1 
ATOM   3058 O O   . VAL C 3 216 ? 175.097 174.121 204.588 1.00 55.89  ? 260 VAL C O   1 
ATOM   3059 C CB  . VAL C 3 216 ? 173.442 174.970 202.184 1.00 55.89  ? 260 VAL C CB  1 
ATOM   3060 C CG1 . VAL C 3 216 ? 174.485 175.253 201.117 1.00 55.89  ? 260 VAL C CG1 1 
ATOM   3061 C CG2 . VAL C 3 216 ? 172.039 175.114 201.618 1.00 55.89  ? 260 VAL C CG2 1 
ATOM   3062 N N   . ILE C 3 217 ? 175.875 172.658 203.052 1.00 56.91  ? 261 ILE C N   1 
ATOM   3063 C CA  . ILE C 3 217 ? 177.124 172.386 203.748 1.00 56.91  ? 261 ILE C CA  1 
ATOM   3064 C C   . ILE C 3 217 ? 178.284 172.589 202.784 1.00 56.91  ? 261 ILE C C   1 
ATOM   3065 O O   . ILE C 3 217 ? 178.112 172.631 201.564 1.00 56.91  ? 261 ILE C O   1 
ATOM   3066 C CB  . ILE C 3 217 ? 177.152 170.960 204.344 1.00 56.91  ? 261 ILE C CB  1 
ATOM   3067 C CG1 . ILE C 3 217 ? 177.986 170.926 205.626 1.00 56.91  ? 261 ILE C CG1 1 
ATOM   3068 C CG2 . ILE C 3 217 ? 177.679 169.957 203.328 1.00 56.91  ? 261 ILE C CG2 1 
ATOM   3069 C CD1 . ILE C 3 217 ? 177.922 169.603 206.350 1.00 56.91  ? 261 ILE C CD1 1 
ATOM   3070 N N   . LEU C 3 218 ? 179.478 172.723 203.353 1.00 62.28  ? 262 LEU C N   1 
ATOM   3071 C CA  . LEU C 3 218 ? 180.693 172.914 202.576 1.00 62.28  ? 262 LEU C CA  1 
ATOM   3072 C C   . LEU C 3 218 ? 181.280 171.565 202.180 1.00 62.28  ? 262 LEU C C   1 
ATOM   3073 O O   . LEU C 3 218 ? 181.231 170.602 202.951 1.00 62.28  ? 262 LEU C O   1 
ATOM   3074 C CB  . LEU C 3 218 ? 181.716 173.725 203.373 1.00 62.28  ? 262 LEU C CB  1 
ATOM   3075 C CG  . LEU C 3 218 ? 182.866 174.369 202.599 1.00 62.28  ? 262 LEU C CG  1 
ATOM   3076 C CD1 . LEU C 3 218 ? 183.166 175.747 203.160 1.00 62.28  ? 262 LEU C CD1 1 
ATOM   3077 C CD2 . LEU C 3 218 ? 184.106 173.496 202.649 1.00 62.28  ? 262 LEU C CD2 1 
ATOM   3078 N N   . VAL C 3 219 ? 181.835 171.502 200.970 1.00 63.81  ? 263 VAL C N   1 
ATOM   3079 C CA  . VAL C 3 219 ? 182.381 170.251 200.458 1.00 63.81  ? 263 VAL C CA  1 
ATOM   3080 C C   . VAL C 3 219 ? 183.637 169.883 201.234 1.00 63.81  ? 263 VAL C C   1 
ATOM   3081 O O   . VAL C 3 219 ? 184.624 170.629 201.243 1.00 63.81  ? 263 VAL C O   1 
ATOM   3082 C CB  . VAL C 3 219 ? 182.673 170.365 198.956 1.00 63.81  ? 263 VAL C CB  1 
ATOM   3083 C CG1 . VAL C 3 219 ? 183.233 169.055 198.427 1.00 63.81  ? 263 VAL C CG1 1 
ATOM   3084 C CG2 . VAL C 3 219 ? 181.413 170.750 198.201 1.00 63.81  ? 263 VAL C CG2 1 
ATOM   3085 N N   . GLY C 3 220 ? 183.608 168.721 201.884 1.00 64.83  ? 264 GLY C N   1 
ATOM   3086 C CA  . GLY C 3 220 ? 184.743 168.215 202.623 1.00 64.83  ? 264 GLY C CA  1 
ATOM   3087 C C   . GLY C 3 220 ? 184.550 168.144 204.123 1.00 64.83  ? 264 GLY C C   1 
ATOM   3088 O O   . GLY C 3 220 ? 185.374 167.524 204.805 1.00 64.83  ? 264 GLY C O   1 
ATOM   3089 N N   . SER C 3 221 ? 183.495 168.749 204.653 1.00 62.82  ? 265 SER C N   1 
ATOM   3090 C CA  . SER C 3 221 ? 183.254 168.751 206.086 1.00 62.82  ? 265 SER C CA  1 
ATOM   3091 C C   . SER C 3 221 ? 182.438 167.529 206.496 1.00 62.82  ? 265 SER C C   1 
ATOM   3092 O O   . SER C 3 221 ? 181.797 166.872 205.674 1.00 62.82  ? 265 SER C O   1 
ATOM   3093 C CB  . SER C 3 221 ? 182.532 170.030 206.509 1.00 62.82  ? 265 SER C CB  1 
ATOM   3094 O OG  . SER C 3 221 ? 181.129 169.882 206.391 1.00 62.82  ? 265 SER C OG  1 
ATOM   3095 N N   . ASP C 3 222 ? 182.471 167.234 207.791 1.00 59.43  ? 266 ASP C N   1 
ATOM   3096 C CA  . ASP C 3 222 ? 181.760 166.090 208.338 1.00 59.43  ? 266 ASP C CA  1 
ATOM   3097 C C   . ASP C 3 222 ? 180.359 166.490 208.782 1.00 59.43  ? 266 ASP C C   1 
ATOM   3098 O O   . ASP C 3 222 ? 180.106 167.640 209.149 1.00 59.43  ? 266 ASP C O   1 
ATOM   3099 C CB  . ASP C 3 222 ? 182.529 165.490 209.515 1.00 59.43  ? 266 ASP C CB  1 
ATOM   3100 C CG  . ASP C 3 222 ? 183.077 166.547 210.449 1.00 59.43  ? 266 ASP C CG  1 
ATOM   3101 O OD1 . ASP C 3 222 ? 182.943 167.747 210.133 1.00 59.43  ? 266 ASP C OD1 1 
ATOM   3102 O OD2 . ASP C 3 222 ? 183.643 166.179 211.500 1.00 59.43  ? 266 ASP C OD2 1 
ATOM   3103 N N   . ILE C 3 223 ? 179.446 165.521 208.745 1.00 51.11  ? 267 ILE C N   1 
ATOM   3104 C CA  . ILE C 3 223 ? 178.059 165.745 209.132 1.00 51.11  ? 267 ILE C CA  1 
ATOM   3105 C C   . ILE C 3 223 ? 177.498 164.440 209.679 1.00 51.11  ? 267 ILE C C   1 
ATOM   3106 O O   . ILE C 3 223 ? 177.883 163.350 209.249 1.00 51.11  ? 267 ILE C O   1 
ATOM   3107 C CB  . ILE C 3 223 ? 177.216 166.276 207.947 1.00 51.11  ? 267 ILE C CB  1 
ATOM   3108 C CG1 . ILE C 3 223 ? 175.835 166.727 208.424 1.00 51.11  ? 267 ILE C CG1 1 
ATOM   3109 C CG2 . ILE C 3 223 ? 177.096 165.227 206.855 1.00 51.11  ? 267 ILE C CG2 1 
ATOM   3110 C CD1 . ILE C 3 223 ? 174.955 167.260 207.319 1.00 51.11  ? 267 ILE C CD1 1 
ATOM   3111 N N   . THR C 3 224 ? 176.593 164.557 210.646 1.00 48.78  ? 268 THR C N   1 
ATOM   3112 C CA  . THR C 3 224 ? 175.980 163.408 211.300 1.00 48.78  ? 268 THR C CA  1 
ATOM   3113 C C   . THR C 3 224 ? 174.471 163.487 211.128 1.00 48.78  ? 268 THR C C   1 
ATOM   3114 O O   . THR C 3 224 ? 173.838 164.435 211.603 1.00 48.78  ? 268 THR C O   1 
ATOM   3115 C CB  . THR C 3 224 ? 176.344 163.362 212.785 1.00 48.78  ? 268 THR C CB  1 
ATOM   3116 O OG1 . THR C 3 224 ? 177.769 163.298 212.927 1.00 48.78  ? 268 THR C OG1 1 
ATOM   3117 C CG2 . THR C 3 224 ? 175.716 162.147 213.448 1.00 48.78  ? 268 THR C CG2 1 
ATOM   3118 N N   . PHE C 3 225 ? 173.900 162.494 210.455 1.00 49.63  ? 269 PHE C N   1 
ATOM   3119 C CA  . PHE C 3 225 ? 172.462 162.407 210.255 1.00 49.63  ? 269 PHE C CA  1 
ATOM   3120 C C   . PHE C 3 225 ? 171.821 161.608 211.383 1.00 49.63  ? 269 PHE C C   1 
ATOM   3121 O O   . PHE C 3 225 ? 172.495 160.952 212.180 1.00 49.63  ? 269 PHE C O   1 
ATOM   3122 C CB  . PHE C 3 225 ? 172.145 161.774 208.898 1.00 49.63  ? 269 PHE C CB  1 
ATOM   3123 C CG  . PHE C 3 225 ? 172.316 162.710 207.739 1.00 49.63  ? 269 PHE C CG  1 
ATOM   3124 C CD1 . PHE C 3 225 ? 171.221 163.337 207.172 1.00 49.63  ? 269 PHE C CD1 1 
ATOM   3125 C CD2 . PHE C 3 225 ? 173.572 162.967 207.219 1.00 49.63  ? 269 PHE C CD2 1 
ATOM   3126 C CE1 . PHE C 3 225 ? 171.375 164.201 206.106 1.00 49.63  ? 269 PHE C CE1 1 
ATOM   3127 C CE2 . PHE C 3 225 ? 173.732 163.830 206.154 1.00 49.63  ? 269 PHE C CE2 1 
ATOM   3128 C CZ  . PHE C 3 225 ? 172.632 164.447 205.597 1.00 49.63  ? 269 PHE C CZ  1 
ATOM   3129 N N   . CYS C 3 226 ? 170.493 161.672 211.445 1.00 54.14  ? 270 CYS C N   1 
ATOM   3130 C CA  . CYS C 3 226 ? 169.747 160.991 212.491 1.00 54.14  ? 270 CYS C CA  1 
ATOM   3131 C C   . CYS C 3 226 ? 168.333 160.724 212.002 1.00 54.14  ? 270 CYS C C   1 
ATOM   3132 O O   . CYS C 3 226 ? 167.753 161.542 211.284 1.00 54.14  ? 270 CYS C O   1 
ATOM   3133 C CB  . CYS C 3 226 ? 169.716 161.817 213.782 1.00 54.14  ? 270 CYS C CB  1 
ATOM   3134 S SG  . CYS C 3 226 ? 168.474 161.291 214.983 1.00 54.14  ? 270 CYS C SG  1 
ATOM   3135 N N   . CYS C 3 227 ? 167.786 159.576 212.394 1.00 57.43  ? 271 CYS C N   1 
ATOM   3136 C CA  . CYS C 3 227 ? 166.434 159.178 212.028 1.00 57.43  ? 271 CYS C CA  1 
ATOM   3137 C C   . CYS C 3 227 ? 165.700 158.693 213.268 1.00 57.43  ? 271 CYS C C   1 
ATOM   3138 O O   . CYS C 3 227 ? 166.187 157.805 213.975 1.00 57.43  ? 271 CYS C O   1 
ATOM   3139 C CB  . CYS C 3 227 ? 166.450 158.080 210.961 1.00 57.43  ? 271 CYS C CB  1 
ATOM   3140 S SG  . CYS C 3 227 ? 164.857 157.264 210.715 1.00 57.43  ? 271 CYS C SG  1 
ATOM   3141 N N   . VAL C 3 228 ? 164.532 159.273 213.526 1.00 64.81  ? 272 VAL C N   1 
ATOM   3142 C CA  . VAL C 3 228 ? 163.698 158.907 214.665 1.00 64.81  ? 272 VAL C CA  1 
ATOM   3143 C C   . VAL C 3 228 ? 162.530 158.081 214.139 1.00 64.81  ? 272 VAL C C   1 
ATOM   3144 O O   . VAL C 3 228 ? 161.826 158.496 213.210 1.00 64.81  ? 272 VAL C O   1 
ATOM   3145 C CB  . VAL C 3 228 ? 163.219 160.140 215.446 1.00 64.81  ? 272 VAL C CB  1 
ATOM   3146 C CG1 . VAL C 3 228 ? 162.541 161.145 214.524 1.00 64.81  ? 272 VAL C CG1 1 
ATOM   3147 C CG2 . VAL C 3 228 ? 162.278 159.723 216.565 1.00 64.81  ? 272 VAL C CG2 1 
ATOM   3148 N N   . SER C 3 229 ? 162.336 156.898 214.719 1.00 74.53  ? 273 SER C N   1 
ATOM   3149 C CA  . SER C 3 229 ? 161.274 155.998 214.299 1.00 74.53  ? 273 SER C CA  1 
ATOM   3150 C C   . SER C 3 229 ? 161.065 154.940 215.370 1.00 74.53  ? 273 SER C C   1 
ATOM   3151 O O   . SER C 3 229 ? 162.004 154.574 216.082 1.00 74.53  ? 273 SER C O   1 
ATOM   3152 C CB  . SER C 3 229 ? 161.601 155.329 212.958 1.00 74.53  ? 273 SER C CB  1 
ATOM   3153 O OG  . SER C 3 229 ? 162.526 154.270 213.131 1.00 74.53  ? 273 SER C OG  1 
ATOM   3154 N N   . GLN C 3 230 ? 159.827 154.455 215.479 1.00 82.55  ? 274 GLN C N   1 
ATOM   3155 C CA  . GLN C 3 230 ? 159.526 153.397 216.436 1.00 82.55  ? 274 GLN C CA  1 
ATOM   3156 C C   . GLN C 3 230 ? 159.841 152.016 215.877 1.00 82.55  ? 274 GLN C C   1 
ATOM   3157 O O   . GLN C 3 230 ? 160.250 151.127 216.631 1.00 82.55  ? 274 GLN C O   1 
ATOM   3158 C CB  . GLN C 3 230 ? 158.058 153.472 216.859 1.00 82.55  ? 274 GLN C CB  1 
ATOM   3159 C CG  . GLN C 3 230 ? 157.728 152.668 218.107 1.00 82.55  ? 274 GLN C CG  1 
ATOM   3160 C CD  . GLN C 3 230 ? 157.335 151.237 217.795 1.00 82.55  ? 274 GLN C CD  1 
ATOM   3161 O OE1 . GLN C 3 230 ? 157.018 150.903 216.653 1.00 82.55  ? 274 GLN C OE1 1 
ATOM   3162 N NE2 . GLN C 3 230 ? 157.358 150.382 218.811 1.00 82.55  ? 274 GLN C NE2 1 
ATOM   3163 N N   . GLU C 3 231 ? 159.657 151.816 214.575 1.00 77.92  ? 275 GLU C N   1 
ATOM   3164 C CA  . GLU C 3 231 ? 159.930 150.526 213.964 1.00 77.92  ? 275 GLU C CA  1 
ATOM   3165 C C   . GLU C 3 231 ? 161.407 150.405 213.596 1.00 77.92  ? 275 GLU C C   1 
ATOM   3166 O O   . GLU C 3 231 ? 162.121 151.399 213.435 1.00 77.92  ? 275 GLU C O   1 
ATOM   3167 C CB  . GLU C 3 231 ? 159.057 150.325 212.726 1.00 77.92  ? 275 GLU C CB  1 
ATOM   3168 C CG  . GLU C 3 231 ? 157.566 150.316 213.024 1.00 77.92  ? 275 GLU C CG  1 
ATOM   3169 C CD  . GLU C 3 231 ? 156.731 149.944 211.816 1.00 77.92  ? 275 GLU C CD  1 
ATOM   3170 O OE1 . GLU C 3 231 ? 157.312 149.493 210.806 1.00 77.92  ? 275 GLU C OE1 1 
ATOM   3171 O OE2 . GLU C 3 231 ? 155.494 150.101 211.876 1.00 77.92  ? 275 GLU C OE2 1 
ATOM   3172 N N   . LYS C 3 232 ? 161.859 149.162 213.463 1.00 71.58  ? 276 LYS C N   1 
ATOM   3173 C CA  . LYS C 3 232 ? 163.266 148.895 213.206 1.00 71.58  ? 276 LYS C CA  1 
ATOM   3174 C C   . LYS C 3 232 ? 163.659 149.335 211.800 1.00 71.58  ? 276 LYS C C   1 
ATOM   3175 O O   . LYS C 3 232 ? 162.889 149.209 210.844 1.00 71.58  ? 276 LYS C O   1 
ATOM   3176 C CB  . LYS C 3 232 ? 163.566 147.407 213.390 1.00 71.58  ? 276 LYS C CB  1 
ATOM   3177 C CG  . LYS C 3 232 ? 165.044 147.057 213.325 1.00 71.58  ? 276 LYS C CG  1 
ATOM   3178 C CD  . LYS C 3 232 ? 165.269 145.568 213.517 1.00 71.58  ? 276 LYS C CD  1 
ATOM   3179 C CE  . LYS C 3 232 ? 166.741 145.214 213.390 1.00 71.58  ? 276 LYS C CE  1 
ATOM   3180 N NZ  . LYS C 3 232 ? 166.982 143.761 213.603 1.00 71.58  ? 276 LYS C NZ  1 
ATOM   3181 N N   . VAL C 3 233 ? 164.877 149.857 211.684 1.00 64.75  ? 277 VAL C N   1 
ATOM   3182 C CA  . VAL C 3 233 ? 165.445 150.289 210.413 1.00 64.75  ? 277 VAL C CA  1 
ATOM   3183 C C   . VAL C 3 233 ? 166.451 149.241 209.960 1.00 64.75  ? 277 VAL C C   1 
ATOM   3184 O O   . VAL C 3 233 ? 167.270 148.767 210.756 1.00 64.75  ? 277 VAL C O   1 
ATOM   3185 C CB  . VAL C 3 233 ? 166.107 151.676 210.536 1.00 64.75  ? 277 VAL C CB  1 
ATOM   3186 C CG1 . VAL C 3 233 ? 166.829 152.042 209.250 1.00 64.75  ? 277 VAL C CG1 1 
ATOM   3187 C CG2 . VAL C 3 233 ? 165.067 152.727 210.887 1.00 64.75  ? 277 VAL C CG2 1 
ATOM   3188 N N   . LEU C 3 234 ? 166.388 148.877 208.680 1.00 64.16  ? 278 LEU C N   1 
ATOM   3189 C CA  . LEU C 3 234 ? 167.234 147.814 208.151 1.00 64.16  ? 278 LEU C CA  1 
ATOM   3190 C C   . LEU C 3 234 ? 168.587 148.331 207.672 1.00 64.16  ? 278 LEU C C   1 
ATOM   3191 O O   . LEU C 3 234 ? 169.630 147.826 208.097 1.00 64.16  ? 278 LEU C O   1 
ATOM   3192 C CB  . LEU C 3 234 ? 166.514 147.088 207.012 1.00 64.16  ? 278 LEU C CB  1 
ATOM   3193 C CG  . LEU C 3 234 ? 165.230 146.349 207.392 1.00 64.16  ? 278 LEU C CG  1 
ATOM   3194 C CD1 . LEU C 3 234 ? 164.662 145.609 206.192 1.00 64.16  ? 278 LEU C CD1 1 
ATOM   3195 C CD2 . LEU C 3 234 ? 165.483 145.393 208.546 1.00 64.16  ? 278 LEU C CD2 1 
ATOM   3196 N N   . SER C 3 235 ? 168.592 149.330 206.793 1.00 58.68  ? 279 SER C N   1 
ATOM   3197 C CA  . SER C 3 235 ? 169.836 149.827 206.227 1.00 58.68  ? 279 SER C CA  1 
ATOM   3198 C C   . SER C 3 235 ? 169.663 151.283 205.821 1.00 58.68  ? 279 SER C C   1 
ATOM   3199 O O   . SER C 3 235 ? 168.548 151.803 205.742 1.00 58.68  ? 279 SER C O   1 
ATOM   3200 C CB  . SER C 3 235 ? 170.278 148.982 205.029 1.00 58.68  ? 279 SER C CB  1 
ATOM   3201 O OG  . SER C 3 235 ? 169.186 148.714 204.167 1.00 58.68  ? 279 SER C OG  1 
ATOM   3202 N N   . ALA C 3 236 ? 170.793 151.937 205.562 1.00 56.13  ? 280 ALA C N   1 
ATOM   3203 C CA  . ALA C 3 236 ? 170.819 153.323 205.123 1.00 56.13  ? 280 ALA C CA  1 
ATOM   3204 C C   . ALA C 3 236 ? 171.831 153.468 203.999 1.00 56.13  ? 280 ALA C C   1 
ATOM   3205 O O   . ALA C 3 236 ? 172.936 152.925 204.077 1.00 56.13  ? 280 ALA C O   1 
ATOM   3206 C CB  . ALA C 3 236 ? 171.171 154.272 206.274 1.00 56.13  ? 280 ALA C CB  1 
ATOM   3207 N N   . LEU C 3 237 ? 171.450 154.203 202.957 1.00 60.08  ? 281 LEU C N   1 
ATOM   3208 C CA  . LEU C 3 237 ? 172.283 154.373 201.778 1.00 60.08  ? 281 LEU C CA  1 
ATOM   3209 C C   . LEU C 3 237 ? 172.450 155.852 201.468 1.00 60.08  ? 281 LEU C C   1 
ATOM   3210 O O   . LEU C 3 237 ? 171.581 156.671 201.777 1.00 60.08  ? 281 LEU C O   1 
ATOM   3211 C CB  . LEU C 3 237 ? 171.683 153.661 200.559 1.00 60.08  ? 281 LEU C CB  1 
ATOM   3212 C CG  . LEU C 3 237 ? 171.018 152.307 200.808 1.00 60.08  ? 281 LEU C CG  1 
ATOM   3213 C CD1 . LEU C 3 237 ? 170.280 151.837 199.564 1.00 60.08  ? 281 LEU C CD1 1 
ATOM   3214 C CD2 . LEU C 3 237 ? 172.045 151.276 201.247 1.00 60.08  ? 281 LEU C CD2 1 
ATOM   3215 N N   . ILE C 3 238 ? 173.578 156.185 200.854 1.00 62.17  ? 282 ILE C N   1 
ATOM   3216 C CA  . ILE C 3 238 ? 173.842 157.532 200.353 1.00 62.17  ? 282 ILE C CA  1 
ATOM   3217 C C   . ILE C 3 238 ? 174.050 157.391 198.850 1.00 62.17  ? 282 ILE C C   1 
ATOM   3218 O O   . ILE C 3 238 ? 175.166 157.162 198.376 1.00 62.17  ? 282 ILE C O   1 
ATOM   3219 C CB  . ILE C 3 238 ? 175.051 158.183 201.028 1.00 62.17  ? 282 ILE C CB  1 
ATOM   3220 C CG1 . ILE C 3 238 ? 174.930 158.082 202.547 1.00 62.17  ? 282 ILE C CG1 1 
ATOM   3221 C CG2 . ILE C 3 238 ? 175.182 159.634 200.597 1.00 62.17  ? 282 ILE C CG2 1 
ATOM   3222 C CD1 . ILE C 3 238 ? 176.156 158.564 203.282 1.00 62.17  ? 282 ILE C CD1 1 
ATOM   3223 N N   . GLY C 3 239 ? 172.972 157.538 198.086 1.00 72.78  ? 283 GLY C N   1 
ATOM   3224 C CA  . GLY C 3 239 ? 173.035 157.268 196.665 1.00 72.78  ? 283 GLY C CA  1 
ATOM   3225 C C   . GLY C 3 239 ? 173.260 155.795 196.396 1.00 72.78  ? 283 GLY C C   1 
ATOM   3226 O O   . GLY C 3 239 ? 172.358 154.975 196.592 1.00 72.78  ? 283 GLY C O   1 
ATOM   3227 N N   . HIS C 3 240 ? 174.464 155.444 195.948 1.00 77.22  ? 284 HIS C N   1 
ATOM   3228 C CA  . HIS C 3 240 ? 174.843 154.055 195.724 1.00 77.22  ? 284 HIS C CA  1 
ATOM   3229 C C   . HIS C 3 240 ? 175.634 153.463 196.883 1.00 77.22  ? 284 HIS C C   1 
ATOM   3230 O O   . HIS C 3 240 ? 175.526 152.263 197.151 1.00 77.22  ? 284 HIS C O   1 
ATOM   3231 C CB  . HIS C 3 240 ? 175.664 153.932 194.436 1.00 77.22  ? 284 HIS C CB  1 
ATOM   3232 C CG  . HIS C 3 240 ? 175.099 154.703 193.284 1.00 77.22  ? 284 HIS C CG  1 
ATOM   3233 N ND1 . HIS C 3 240 ? 173.937 154.336 192.641 1.00 77.22  ? 284 HIS C ND1 1 
ATOM   3234 C CD2 . HIS C 3 240 ? 175.538 155.821 192.659 1.00 77.22  ? 284 HIS C CD2 1 
ATOM   3235 C CE1 . HIS C 3 240 ? 173.684 155.195 191.669 1.00 77.22  ? 284 HIS C CE1 1 
ATOM   3236 N NE2 . HIS C 3 240 ? 174.640 156.105 191.659 1.00 77.22  ? 284 HIS C NE2 1 
ATOM   3237 N N   . THR C 3 241 ? 176.422 154.279 197.575 1.00 70.18  ? 285 THR C N   1 
ATOM   3238 C CA  . THR C 3 241 ? 177.269 153.788 198.652 1.00 70.18  ? 285 THR C CA  1 
ATOM   3239 C C   . THR C 3 241 ? 176.438 153.448 199.886 1.00 70.18  ? 285 THR C C   1 
ATOM   3240 O O   . THR C 3 241 ? 175.457 154.124 200.210 1.00 70.18  ? 285 THR C O   1 
ATOM   3241 C CB  . THR C 3 241 ? 178.329 154.834 199.004 1.00 70.18  ? 285 THR C CB  1 
ATOM   3242 O OG1 . THR C 3 241 ? 179.041 155.207 197.819 1.00 70.18  ? 285 THR C OG1 1 
ATOM   3243 C CG2 . THR C 3 241 ? 179.318 154.285 200.021 1.00 70.18  ? 285 THR C CG2 1 
ATOM   3244 N N   . ASN C 3 242 ? 176.839 152.385 200.575 1.00 69.56  ? 286 ASN C N   1 
ATOM   3245 C CA  . ASN C 3 242 ? 176.227 151.978 201.830 1.00 69.56  ? 286 ASN C CA  1 
ATOM   3246 C C   . ASN C 3 242 ? 177.103 152.407 203.003 1.00 69.56  ? 286 ASN C C   1 
ATOM   3247 O O   . ASN C 3 242 ? 178.310 152.617 202.865 1.00 69.56  ? 286 ASN C O   1 
ATOM   3248 C CB  . ASN C 3 242 ? 176.006 150.463 201.860 1.00 69.56  ? 286 ASN C CB  1 
ATOM   3249 C CG  . ASN C 3 242 ? 174.934 150.046 202.852 1.00 69.56  ? 286 ASN C CG  1 
ATOM   3250 O OD1 . ASN C 3 242 ? 174.748 150.683 203.888 1.00 69.56  ? 286 ASN C OD1 1 
ATOM   3251 N ND2 . ASN C 3 242 ? 174.223 148.970 202.536 1.00 69.56  ? 286 ASN C ND2 1 
ATOM   3252 N N   . CYS C 3 243 ? 176.473 152.536 204.171 1.00 68.52  ? 287 CYS C N   1 
ATOM   3253 C CA  . CYS C 3 243 ? 177.156 152.980 205.377 1.00 68.52  ? 287 CYS C CA  1 
ATOM   3254 C C   . CYS C 3 243 ? 176.637 152.209 206.583 1.00 68.52  ? 287 CYS C C   1 
ATOM   3255 O O   . CYS C 3 243 ? 175.438 151.902 206.656 1.00 68.52  ? 287 CYS C O   1 
ATOM   3256 C CB  . CYS C 3 243 ? 176.966 154.485 205.608 1.00 68.52  ? 287 CYS C CB  1 
ATOM   3257 S SG  . CYS C 3 243 ? 177.734 155.532 204.353 1.00 68.52  ? 287 CYS C SG  1 
ATOM   3258 N N   . PRO C 3 244 ? 177.508 151.885 207.537 1.00 68.97  ? 288 PRO C N   1 
ATOM   3259 C CA  . PRO C 3 244 ? 177.058 151.140 208.718 1.00 68.97  ? 288 PRO C CA  1 
ATOM   3260 C C   . PRO C 3 244 ? 176.260 152.026 209.660 1.00 68.97  ? 288 PRO C C   1 
ATOM   3261 O O   . PRO C 3 244 ? 176.473 153.238 209.736 1.00 68.97  ? 288 PRO C O   1 
ATOM   3262 C CB  . PRO C 3 244 ? 178.369 150.676 209.362 1.00 68.97  ? 288 PRO C CB  1 
ATOM   3263 C CG  . PRO C 3 244 ? 179.365 151.702 208.942 1.00 68.97  ? 288 PRO C CG  1 
ATOM   3264 C CD  . PRO C 3 244 ? 178.958 152.145 207.562 1.00 68.97  ? 288 PRO C CD  1 
ATOM   3265 N N   . LEU C 3 245 ? 175.332 151.405 210.382 1.00 60.21  ? 289 LEU C N   1 
ATOM   3266 C CA  . LEU C 3 245 ? 174.480 152.133 211.309 1.00 60.21  ? 289 LEU C CA  1 
ATOM   3267 C C   . LEU C 3 245 ? 175.116 152.199 212.691 1.00 60.21  ? 289 LEU C C   1 
ATOM   3268 O O   . LEU C 3 245 ? 175.837 151.287 213.105 1.00 60.21  ? 289 LEU C O   1 
ATOM   3269 C CB  . LEU C 3 245 ? 173.105 151.472 211.404 1.00 60.21  ? 289 LEU C CB  1 
ATOM   3270 C CG  . LEU C 3 245 ? 172.256 151.468 210.134 1.00 60.21  ? 289 LEU C CG  1 
ATOM   3271 C CD1 . LEU C 3 245 ? 170.897 150.849 210.409 1.00 60.21  ? 289 LEU C CD1 1 
ATOM   3272 C CD2 . LEU C 3 245 ? 172.105 152.876 209.590 1.00 60.21  ? 289 LEU C CD2 1 
ATOM   3273 N N   . ILE C 3 246 ? 174.845 153.289 213.400 1.00 61.96  ? 290 ILE C N   1 
ATOM   3274 C CA  . ILE C 3 246 ? 175.277 153.474 214.780 1.00 61.96  ? 290 ILE C CA  1 
ATOM   3275 C C   . ILE C 3 246 ? 174.025 153.494 215.644 1.00 61.96  ? 290 ILE C C   1 
ATOM   3276 O O   . ILE C 3 246 ? 173.223 154.433 215.570 1.00 61.96  ? 290 ILE C O   1 
ATOM   3277 C CB  . ILE C 3 246 ? 176.098 154.757 214.957 1.00 61.96  ? 290 ILE C CB  1 
ATOM   3278 C CG1 . ILE C 3 246 ? 177.345 154.716 214.073 1.00 61.96  ? 290 ILE C CG1 1 
ATOM   3279 C CG2 . ILE C 3 246 ? 176.481 154.946 216.416 1.00 61.96  ? 290 ILE C CG2 1 
ATOM   3280 C CD1 . ILE C 3 246 ? 178.233 155.930 214.218 1.00 61.96  ? 290 ILE C CD1 1 
ATOM   3281 N N   . HIS C 3 247 ? 173.852 152.459 216.461 1.00 66.90  ? 291 HIS C N   1 
ATOM   3282 C CA  . HIS C 3 247 ? 172.643 152.336 217.262 1.00 66.90  ? 291 HIS C CA  1 
ATOM   3283 C C   . HIS C 3 247 ? 172.614 153.384 218.368 1.00 66.90  ? 291 HIS C C   1 
ATOM   3284 O O   . HIS C 3 247 ? 173.644 153.720 218.958 1.00 66.90  ? 291 HIS C O   1 
ATOM   3285 C CB  . HIS C 3 247 ? 172.548 150.935 217.864 1.00 66.90  ? 291 HIS C CB  1 
ATOM   3286 C CG  . HIS C 3 247 ? 172.223 149.870 216.863 1.00 66.90  ? 291 HIS C CG  1 
ATOM   3287 N ND1 . HIS C 3 247 ? 170.929 149.516 216.547 1.00 66.90  ? 291 HIS C ND1 1 
ATOM   3288 C CD2 . HIS C 3 247 ? 173.023 149.083 216.107 1.00 66.90  ? 291 HIS C CD2 1 
ATOM   3289 C CE1 . HIS C 3 247 ? 170.946 148.557 215.640 1.00 66.90  ? 291 HIS C CE1 1 
ATOM   3290 N NE2 . HIS C 3 247 ? 172.205 148.275 215.356 1.00 66.90  ? 291 HIS C NE2 1 
ATOM   3291 N N   . LEU C 3 248 ? 171.422 153.898 218.642 1.00 67.30  ? 292 LEU C N   1 
ATOM   3292 C CA  . LEU C 3 248 ? 171.188 154.889 219.682 1.00 67.30  ? 292 LEU C CA  1 
ATOM   3293 C C   . LEU C 3 248 ? 170.155 154.347 220.669 1.00 67.30  ? 292 LEU C C   1 
ATOM   3294 O O   . LEU C 3 248 ? 169.768 153.177 220.616 1.00 67.30  ? 292 LEU C O   1 
ATOM   3295 C CB  . LEU C 3 248 ? 170.737 156.217 219.070 1.00 67.30  ? 292 LEU C CB  1 
ATOM   3296 C CG  . LEU C 3 248 ? 171.789 157.022 218.308 1.00 67.30  ? 292 LEU C CG  1 
ATOM   3297 C CD1 . LEU C 3 248 ? 171.156 158.241 217.661 1.00 67.30  ? 292 LEU C CD1 1 
ATOM   3298 C CD2 . LEU C 3 248 ? 172.920 157.432 219.234 1.00 67.30  ? 292 LEU C CD2 1 
ATOM   3299 N N   . ASP C 3 249 ? 169.717 155.210 221.582 1.00 78.71  ? 293 ASP C N   1 
ATOM   3300 C CA  . ASP C 3 249 ? 168.679 154.835 222.532 1.00 78.71  ? 293 ASP C CA  1 
ATOM   3301 C C   . ASP C 3 249 ? 167.381 154.534 221.796 1.00 78.71  ? 293 ASP C C   1 
ATOM   3302 O O   . ASP C 3 249 ? 166.798 155.416 221.159 1.00 78.71  ? 293 ASP C O   1 
ATOM   3303 C CB  . ASP C 3 249 ? 168.470 155.952 223.552 1.00 78.71  ? 293 ASP C CB  1 
ATOM   3304 C CG  . ASP C 3 249 ? 167.648 155.506 224.744 1.00 78.71  ? 293 ASP C CG  1 
ATOM   3305 O OD1 . ASP C 3 249 ? 166.973 156.360 225.356 1.00 78.71  ? 293 ASP C OD1 1 
ATOM   3306 O OD2 . ASP C 3 249 ? 167.676 154.300 225.070 1.00 78.71  ? 293 ASP C OD2 1 
ATOM   3307 N N   . GLY C 3 250 ? 166.931 153.285 221.886 1.00 78.67  ? 294 GLY C N   1 
ATOM   3308 C CA  . GLY C 3 250 ? 165.741 152.877 221.165 1.00 78.67  ? 294 GLY C CA  1 
ATOM   3309 C C   . GLY C 3 250 ? 166.068 152.398 219.759 1.00 78.67  ? 294 GLY C C   1 
ATOM   3310 O O   . GLY C 3 250 ? 167.166 151.916 219.476 1.00 78.67  ? 294 GLY C O   1 
ATOM   3311 N N   . GLU C 3 251 ? 165.091 152.538 218.869 1.00 77.07  ? 295 GLU C N   1 
ATOM   3312 C CA  . GLU C 3 251 ? 165.237 152.116 217.483 1.00 77.07  ? 295 GLU C CA  1 
ATOM   3313 C C   . GLU C 3 251 ? 165.861 153.186 216.599 1.00 77.07  ? 295 GLU C C   1 
ATOM   3314 O O   . GLU C 3 251 ? 166.071 152.939 215.407 1.00 77.07  ? 295 GLU C O   1 
ATOM   3315 C CB  . GLU C 3 251 ? 163.876 151.706 216.909 1.00 77.07  ? 295 GLU C CB  1 
ATOM   3316 C CG  . GLU C 3 251 ? 163.396 150.331 217.352 1.00 77.07  ? 295 GLU C CG  1 
ATOM   3317 C CD  . GLU C 3 251 ? 163.030 150.283 218.823 1.00 77.07  ? 295 GLU C CD  1 
ATOM   3318 O OE1 . GLU C 3 251 ? 163.395 149.296 219.495 1.00 77.07  ? 295 GLU C OE1 1 
ATOM   3319 O OE2 . GLU C 3 251 ? 162.383 151.235 219.307 1.00 77.07  ? 295 GLU C OE2 1 
ATOM   3320 N N   . ASN C 3 252 ? 166.159 154.361 217.146 1.00 71.11  ? 296 ASN C N   1 
ATOM   3321 C CA  . ASN C 3 252 ? 166.764 155.422 216.355 1.00 71.11  ? 296 ASN C CA  1 
ATOM   3322 C C   . ASN C 3 252 ? 168.197 155.059 215.989 1.00 71.11  ? 296 ASN C C   1 
ATOM   3323 O O   . ASN C 3 252 ? 168.936 154.490 216.797 1.00 71.11  ? 296 ASN C O   1 
ATOM   3324 C CB  . ASN C 3 252 ? 166.735 156.739 217.128 1.00 71.11  ? 296 ASN C CB  1 
ATOM   3325 C CG  . ASN C 3 252 ? 165.416 156.969 217.838 1.00 71.11  ? 296 ASN C CG  1 
ATOM   3326 O OD1 . ASN C 3 252 ? 164.367 156.507 217.388 1.00 71.11  ? 296 ASN C OD1 1 
ATOM   3327 N ND2 . ASN C 3 252 ? 165.461 157.685 218.955 1.00 71.11  ? 296 ASN C ND2 1 
ATOM   3328 N N   . VAL C 3 253 ? 168.587 155.387 214.760 1.00 61.21  ? 297 VAL C N   1 
ATOM   3329 C CA  . VAL C 3 253 ? 169.931 155.115 214.269 1.00 61.21  ? 297 VAL C CA  1 
ATOM   3330 C C   . VAL C 3 253 ? 170.534 156.407 213.740 1.00 61.21  ? 297 VAL C C   1 
ATOM   3331 O O   . VAL C 3 253 ? 169.822 157.363 213.417 1.00 61.21  ? 297 VAL C O   1 
ATOM   3332 C CB  . VAL C 3 253 ? 169.941 154.025 213.174 1.00 61.21  ? 297 VAL C CB  1 
ATOM   3333 C CG1 . VAL C 3 253 ? 169.275 152.756 213.677 1.00 61.21  ? 297 VAL C CG1 1 
ATOM   3334 C CG2 . VAL C 3 253 ? 169.257 154.530 211.917 1.00 61.21  ? 297 VAL C CG2 1 
ATOM   3335 N N   . ALA C 3 254 ? 171.861 156.432 213.658 1.00 60.45  ? 298 ALA C N   1 
ATOM   3336 C CA  . ALA C 3 254 ? 172.587 157.588 213.160 1.00 60.45  ? 298 ALA C CA  1 
ATOM   3337 C C   . ALA C 3 254 ? 173.771 157.115 212.332 1.00 60.45  ? 298 ALA C C   1 
ATOM   3338 O O   . ALA C 3 254 ? 174.278 156.007 212.522 1.00 60.45  ? 298 ALA C O   1 
ATOM   3339 C CB  . ALA C 3 254 ? 173.069 158.488 214.304 1.00 60.45  ? 298 ALA C CB  1 
ATOM   3340 N N   . ILE C 3 255 ? 174.208 157.966 211.408 1.00 52.50  ? 299 ILE C N   1 
ATOM   3341 C CA  . ILE C 3 255 ? 175.327 157.656 210.530 1.00 52.50  ? 299 ILE C CA  1 
ATOM   3342 C C   . ILE C 3 255 ? 176.272 158.847 210.492 1.00 52.50  ? 299 ILE C C   1 
ATOM   3343 O O   . ILE C 3 255 ? 175.851 160.003 210.598 1.00 52.50  ? 299 ILE C O   1 
ATOM   3344 C CB  . ILE C 3 255 ? 174.858 157.289 209.106 1.00 52.50  ? 299 ILE C CB  1 
ATOM   3345 C CG1 . ILE C 3 255 ? 173.900 158.353 208.569 1.00 52.50  ? 299 ILE C CG1 1 
ATOM   3346 C CG2 . ILE C 3 255 ? 174.198 155.923 209.098 1.00 52.50  ? 299 ILE C CG2 1 
ATOM   3347 C CD1 . ILE C 3 255 ? 173.372 158.051 207.185 1.00 52.50  ? 299 ILE C CD1 1 
ATOM   3348 N N   . LYS C 3 256 ? 177.560 158.555 210.342 1.00 51.10  ? 300 LYS C N   1 
ATOM   3349 C CA  . LYS C 3 256 ? 178.598 159.572 210.251 1.00 51.10  ? 300 LYS C CA  1 
ATOM   3350 C C   . LYS C 3 256 ? 179.099 159.657 208.818 1.00 51.10  ? 300 LYS C C   1 
ATOM   3351 O O   . LYS C 3 256 ? 179.342 158.628 208.179 1.00 51.10  ? 300 LYS C O   1 
ATOM   3352 C CB  . LYS C 3 256 ? 179.761 159.260 211.195 1.00 51.10  ? 300 LYS C CB  1 
ATOM   3353 C CG  . LYS C 3 256 ? 179.432 159.420 212.666 1.00 51.10  ? 300 LYS C CG  1 
ATOM   3354 C CD  . LYS C 3 256 ? 180.681 159.276 213.518 1.00 51.10  ? 300 LYS C CD  1 
ATOM   3355 C CE  . LYS C 3 256 ? 180.384 159.540 214.984 1.00 51.10  ? 300 LYS C CE  1 
ATOM   3356 N NZ  . LYS C 3 256 ? 181.618 159.490 215.814 1.00 51.10  ? 300 LYS C NZ  1 
ATOM   3357 N N   . ILE C 3 257 ? 179.249 160.879 208.318 1.00 51.90  ? 301 ILE C N   1 
ATOM   3358 C CA  . ILE C 3 257 ? 179.775 161.134 206.984 1.00 51.90  ? 301 ILE C CA  1 
ATOM   3359 C C   . ILE C 3 257 ? 181.005 162.016 207.124 1.00 51.90  ? 301 ILE C C   1 
ATOM   3360 O O   . ILE C 3 257 ? 180.947 163.071 207.766 1.00 51.90  ? 301 ILE C O   1 
ATOM   3361 C CB  . ILE C 3 257 ? 178.726 161.799 206.076 1.00 51.90  ? 301 ILE C CB  1 
ATOM   3362 C CG1 . ILE C 3 257 ? 177.457 160.950 206.016 1.00 51.90  ? 301 ILE C CG1 1 
ATOM   3363 C CG2 . ILE C 3 257 ? 179.291 162.016 204.683 1.00 51.90  ? 301 ILE C CG2 1 
ATOM   3364 C CD1 . ILE C 3 257 ? 176.331 161.604 205.256 1.00 51.90  ? 301 ILE C CD1 1 
ATOM   3365 N N   . ARG C 3 258 ? 182.114 161.585 206.530 1.00 62.19  ? 302 ARG C N   1 
ATOM   3366 C CA  . ARG C 3 258 ? 183.368 162.321 206.590 1.00 62.19  ? 302 ARG C CA  1 
ATOM   3367 C C   . ARG C 3 258 ? 183.899 162.533 205.182 1.00 62.19  ? 302 ARG C C   1 
ATOM   3368 O O   . ARG C 3 258 ? 183.833 161.630 204.343 1.00 62.19  ? 302 ARG C O   1 
ATOM   3369 C CB  . ARG C 3 258 ? 184.410 161.581 207.436 1.00 62.19  ? 302 ARG C CB  1 
ATOM   3370 C CG  . ARG C 3 258 ? 183.932 161.215 208.829 1.00 62.19  ? 302 ARG C CG  1 
ATOM   3371 C CD  . ARG C 3 258 ? 184.809 160.139 209.446 1.00 62.19  ? 302 ARG C CD  1 
ATOM   3372 N NE  . ARG C 3 258 ? 184.251 159.629 210.695 1.00 62.19  ? 302 ARG C NE  1 
ATOM   3373 C CZ  . ARG C 3 258 ? 184.734 158.582 211.355 1.00 62.19  ? 302 ARG C CZ  1 
ATOM   3374 N NH1 . ARG C 3 258 ? 185.787 157.928 210.886 1.00 62.19  ? 302 ARG C NH1 1 
ATOM   3375 N NH2 . ARG C 3 258 ? 184.162 158.187 212.485 1.00 62.19  ? 302 ARG C NH2 1 
ATOM   3376 N N   . ASN C 3 259 ? 184.427 163.733 204.933 1.00 70.27  ? 303 ASN C N   1 
ATOM   3377 C CA  . ASN C 3 259 ? 184.998 164.104 203.639 1.00 70.27  ? 303 ASN C CA  1 
ATOM   3378 C C   . ASN C 3 259 ? 183.980 163.901 202.515 1.00 70.27  ? 303 ASN C C   1 
ATOM   3379 O O   . ASN C 3 259 ? 184.223 163.195 201.535 1.00 70.27  ? 303 ASN C O   1 
ATOM   3380 C CB  . ASN C 3 259 ? 186.287 163.322 203.368 1.00 70.27  ? 303 ASN C CB  1 
ATOM   3381 C CG  . ASN C 3 259 ? 187.215 164.042 202.414 1.00 70.27  ? 303 ASN C CG  1 
ATOM   3382 O OD1 . ASN C 3 259 ? 187.101 165.251 202.214 1.00 70.27  ? 303 ASN C OD1 1 
ATOM   3383 N ND2 . ASN C 3 259 ? 188.141 163.301 201.816 1.00 70.27  ? 303 ASN C ND2 1 
ATOM   3384 N N   . ILE C 3 260 ? 182.820 164.539 202.681 1.00 65.48  ? 304 ILE C N   1 
ATOM   3385 C CA  . ILE C 3 260 ? 181.741 164.396 201.712 1.00 65.48  ? 304 ILE C CA  1 
ATOM   3386 C C   . ILE C 3 260 ? 182.152 165.028 200.388 1.00 65.48  ? 304 ILE C C   1 
ATOM   3387 O O   . ILE C 3 260 ? 182.733 166.121 200.349 1.00 65.48  ? 304 ILE C O   1 
ATOM   3388 C CB  . ILE C 3 260 ? 180.443 165.016 202.260 1.00 65.48  ? 304 ILE C CB  1 
ATOM   3389 C CG1 . ILE C 3 260 ? 179.324 164.935 201.221 1.00 65.48  ? 304 ILE C CG1 1 
ATOM   3390 C CG2 . ILE C 3 260 ? 180.669 166.454 202.695 1.00 65.48  ? 304 ILE C CG2 1 
ATOM   3391 C CD1 . ILE C 3 260 ? 178.014 165.519 201.696 1.00 65.48  ? 304 ILE C CD1 1 
ATOM   3392 N N   . SER C 3 261 ? 181.866 164.329 199.293 1.00 67.18  ? 305 SER C N   1 
ATOM   3393 C CA  . SER C 3 261 ? 182.238 164.794 197.968 1.00 67.18  ? 305 SER C CA  1 
ATOM   3394 C C   . SER C 3 261 ? 181.248 165.849 197.477 1.00 67.18  ? 305 SER C C   1 
ATOM   3395 O O   . SER C 3 261 ? 180.280 166.201 198.157 1.00 67.18  ? 305 SER C O   1 
ATOM   3396 C CB  . SER C 3 261 ? 182.313 163.618 196.997 1.00 67.18  ? 305 SER C CB  1 
ATOM   3397 O OG  . SER C 3 261 ? 181.063 162.956 196.904 1.00 67.18  ? 305 SER C OG  1 
ATOM   3398 N N   . VAL C 3 262 ? 181.498 166.361 196.272 1.00 69.00  ? 306 VAL C N   1 
ATOM   3399 C CA  . VAL C 3 262 ? 180.622 167.367 195.685 1.00 69.00  ? 306 VAL C CA  1 
ATOM   3400 C C   . VAL C 3 262 ? 179.285 166.730 195.334 1.00 69.00  ? 306 VAL C C   1 
ATOM   3401 O O   . VAL C 3 262 ? 179.227 165.713 194.631 1.00 69.00  ? 306 VAL C O   1 
ATOM   3402 C CB  . VAL C 3 262 ? 181.278 167.997 194.448 1.00 69.00  ? 306 VAL C CB  1 
ATOM   3403 C CG1 . VAL C 3 262 ? 180.360 169.042 193.837 1.00 69.00  ? 306 VAL C CG1 1 
ATOM   3404 C CG2 . VAL C 3 262 ? 182.620 168.608 194.815 1.00 69.00  ? 306 VAL C CG2 1 
ATOM   3405 N N   . SER C 3 263 ? 178.203 167.326 195.824 1.00 66.66  ? 307 SER C N   1 
ATOM   3406 C CA  . SER C 3 263 ? 176.871 166.809 195.559 1.00 66.66  ? 307 SER C CA  1 
ATOM   3407 C C   . SER C 3 263 ? 176.346 167.329 194.227 1.00 66.66  ? 307 SER C C   1 
ATOM   3408 O O   . SER C 3 263 ? 176.710 168.416 193.771 1.00 66.66  ? 307 SER C O   1 
ATOM   3409 C CB  . SER C 3 263 ? 175.911 167.196 196.682 1.00 66.66  ? 307 SER C CB  1 
ATOM   3410 O OG  . SER C 3 263 ? 174.568 167.150 196.237 1.00 66.66  ? 307 SER C OG  1 
ATOM   3411 N N   . ALA C 3 264 ? 175.478 166.537 193.605 1.00 69.83  ? 308 ALA C N   1 
ATOM   3412 C CA  . ALA C 3 264 ? 174.877 166.912 192.336 1.00 69.83  ? 308 ALA C CA  1 
ATOM   3413 C C   . ALA C 3 264 ? 173.778 167.950 192.560 1.00 69.83  ? 308 ALA C C   1 
ATOM   3414 O O   . ALA C 3 264 ? 173.542 168.418 193.677 1.00 69.83  ? 308 ALA C O   1 
ATOM   3415 C CB  . ALA C 3 264 ? 174.335 165.677 191.620 1.00 69.83  ? 308 ALA C CB  1 
ATOM   3416 N N   . SER C 3 265 ? 173.097 168.319 191.473 1.00 75.63  ? 309 SER C N   1 
ATOM   3417 C CA  . SER C 3 265 ? 172.026 169.307 191.568 1.00 75.63  ? 309 SER C CA  1 
ATOM   3418 C C   . SER C 3 265 ? 170.864 168.777 192.395 1.00 75.63  ? 309 SER C C   1 
ATOM   3419 O O   . SER C 3 265 ? 170.384 169.447 193.316 1.00 75.63  ? 309 SER C O   1 
ATOM   3420 C CB  . SER C 3 265 ? 171.551 169.701 190.172 1.00 75.63  ? 309 SER C CB  1 
ATOM   3421 O OG  . SER C 3 265 ? 170.535 168.824 189.719 1.00 75.63  ? 309 SER C OG  1 
ATOM   3422 N N   . SER C 3 266 ? 170.392 167.570 192.074 1.00 70.25  ? 310 SER C N   1 
ATOM   3423 C CA  . SER C 3 266 ? 169.301 166.979 192.840 1.00 70.25  ? 310 SER C CA  1 
ATOM   3424 C C   . SER C 3 266 ? 169.715 166.689 194.276 1.00 70.25  ? 310 SER C C   1 
ATOM   3425 O O   . SER C 3 266 ? 168.854 166.565 195.153 1.00 70.25  ? 310 SER C O   1 
ATOM   3426 C CB  . SER C 3 266 ? 168.814 165.700 192.159 1.00 70.25  ? 310 SER C CB  1 
ATOM   3427 O OG  . SER C 3 266 ? 167.855 165.033 192.960 1.00 70.25  ? 310 SER C OG  1 
ATOM   3428 N N   . GLY C 3 267 ? 171.015 166.575 194.535 1.00 60.59  ? 311 GLY C N   1 
ATOM   3429 C CA  . GLY C 3 267 ? 171.500 166.327 195.877 1.00 60.59  ? 311 GLY C CA  1 
ATOM   3430 C C   . GLY C 3 267 ? 171.711 164.857 196.167 1.00 60.59  ? 311 GLY C C   1 
ATOM   3431 O O   . GLY C 3 267 ? 170.908 164.016 195.752 1.00 60.59  ? 311 GLY C O   1 
ATOM   3432 N N   . THR C 3 268 ? 172.785 164.531 196.884 1.00 58.92  ? 312 THR C N   1 
ATOM   3433 C CA  . THR C 3 268 ? 173.078 163.145 197.246 1.00 58.92  ? 312 THR C CA  1 
ATOM   3434 C C   . THR C 3 268 ? 172.106 162.730 198.346 1.00 58.92  ? 312 THR C C   1 
ATOM   3435 O O   . THR C 3 268 ? 172.406 162.767 199.542 1.00 58.92  ? 312 THR C O   1 
ATOM   3436 C CB  . THR C 3 268 ? 174.527 162.992 197.693 1.00 58.92  ? 312 THR C CB  1 
ATOM   3437 O OG1 . THR C 3 268 ? 174.745 163.755 198.884 1.00 58.92  ? 312 THR C OG1 1 
ATOM   3438 C CG2 . THR C 3 268 ? 175.470 163.477 196.605 1.00 58.92  ? 312 THR C CG2 1 
ATOM   3439 N N   . ASN C 3 269 ? 170.895 162.383 197.931 1.00 54.19  ? 313 ASN C N   1 
ATOM   3440 C CA  . ASN C 3 269 ? 169.842 162.030 198.877 1.00 54.19  ? 313 ASN C CA  1 
ATOM   3441 C C   . ASN C 3 269 ? 170.034 160.770 199.694 1.00 54.19  ? 313 ASN C C   1 
ATOM   3442 O O   . ASN C 3 269 ? 169.862 159.668 199.199 1.00 54.19  ? 313 ASN C O   1 
ATOM   3443 C CB  . ASN C 3 269 ? 168.483 161.990 198.183 1.00 54.19  ? 313 ASN C CB  1 
ATOM   3444 C CG  . ASN C 3 269 ? 168.514 161.210 196.900 1.00 54.19  ? 313 ASN C CG  1 
ATOM   3445 O OD1 . ASN C 3 269 ? 167.573 161.247 196.113 1.00 54.19  ? 313 ASN C OD1 1 
ATOM   3446 N ND2 . ASN C 3 269 ? 169.605 160.502 196.675 1.00 54.19  ? 313 ASN C ND2 1 
ATOM   3447 N N   . VAL C 3 270 ? 170.365 160.953 200.964 1.00 51.32  ? 314 VAL C N   1 
ATOM   3448 C CA  . VAL C 3 270 ? 170.557 159.836 201.880 1.00 51.32  ? 314 VAL C CA  1 
ATOM   3449 C C   . VAL C 3 270 ? 169.191 159.257 202.231 1.00 51.32  ? 314 VAL C C   1 
ATOM   3450 O O   . VAL C 3 270 ? 168.258 159.994 202.566 1.00 51.32  ? 314 VAL C O   1 
ATOM   3451 C CB  . VAL C 3 270 ? 171.328 160.274 203.134 1.00 51.32  ? 314 VAL C CB  1 
ATOM   3452 C CG1 . VAL C 3 270 ? 170.611 161.409 203.845 1.00 51.32  ? 314 VAL C CG1 1 
ATOM   3453 C CG2 . VAL C 3 270 ? 171.518 159.095 204.075 1.00 51.32  ? 314 VAL C CG2 1 
ATOM   3454 N N   . VAL C 3 271 ? 169.060 157.938 202.118 1.00 53.66  ? 315 VAL C N   1 
ATOM   3455 C CA  . VAL C 3 271 ? 167.793 157.250 202.332 1.00 53.66  ? 315 VAL C CA  1 
ATOM   3456 C C   . VAL C 3 271 ? 167.943 156.268 203.484 1.00 53.66  ? 315 VAL C C   1 
ATOM   3457 O O   . VAL C 3 271 ? 169.030 155.726 203.716 1.00 53.66  ? 315 VAL C O   1 
ATOM   3458 C CB  . VAL C 3 271 ? 167.318 156.530 201.052 1.00 53.66  ? 315 VAL C CB  1 
ATOM   3459 C CG1 . VAL C 3 271 ? 167.293 157.499 199.886 1.00 53.66  ? 315 VAL C CG1 1 
ATOM   3460 C CG2 . VAL C 3 271 ? 168.219 155.352 200.734 1.00 53.66  ? 315 VAL C CG2 1 
ATOM   3461 N N   . PHE C 3 272 ? 166.855 156.061 204.219 1.00 53.37  ? 316 PHE C N   1 
ATOM   3462 C CA  . PHE C 3 272 ? 166.785 155.074 205.289 1.00 53.37  ? 316 PHE C CA  1 
ATOM   3463 C C   . PHE C 3 272 ? 165.696 154.073 204.933 1.00 53.37  ? 316 PHE C C   1 
ATOM   3464 O O   . PHE C 3 272 ? 164.511 154.422 204.921 1.00 53.37  ? 316 PHE C O   1 
ATOM   3465 C CB  . PHE C 3 272 ? 166.489 155.734 206.636 1.00 53.37  ? 316 PHE C CB  1 
ATOM   3466 C CG  . PHE C 3 272 ? 167.672 156.428 207.252 1.00 53.37  ? 316 PHE C CG  1 
ATOM   3467 C CD1 . PHE C 3 272 ? 168.371 155.842 208.294 1.00 53.37  ? 316 PHE C CD1 1 
ATOM   3468 C CD2 . PHE C 3 272 ? 168.080 157.669 206.795 1.00 53.37  ? 316 PHE C CD2 1 
ATOM   3469 C CE1 . PHE C 3 272 ? 169.455 156.478 208.863 1.00 53.37  ? 316 PHE C CE1 1 
ATOM   3470 C CE2 . PHE C 3 272 ? 169.165 158.309 207.361 1.00 53.37  ? 316 PHE C CE2 1 
ATOM   3471 C CZ  . PHE C 3 272 ? 169.852 157.712 208.395 1.00 53.37  ? 316 PHE C CZ  1 
ATOM   3472 N N   . THR C 3 273 ? 166.092 152.837 204.650 1.00 61.47  ? 317 THR C N   1 
ATOM   3473 C CA  . THR C 3 273 ? 165.177 151.812 204.168 1.00 61.47  ? 317 THR C CA  1 
ATOM   3474 C C   . THR C 3 273 ? 164.765 150.902 205.314 1.00 61.47  ? 317 THR C C   1 
ATOM   3475 O O   . THR C 3 273 ? 165.616 150.424 206.071 1.00 61.47  ? 317 THR C O   1 
ATOM   3476 C CB  . THR C 3 273 ? 165.817 150.985 203.050 1.00 61.47  ? 317 THR C CB  1 
ATOM   3477 O OG1 . THR C 3 273 ? 167.083 150.480 203.494 1.00 61.47  ? 317 THR C OG1 1 
ATOM   3478 C CG2 . THR C 3 273 ? 166.025 151.838 201.808 1.00 61.47  ? 317 THR C CG2 1 
ATOM   3479 N N   . THR C 3 274 ? 163.465 150.669 205.438 1.00 65.91  ? 318 THR C N   1 
ATOM   3480 C CA  . THR C 3 274 ? 162.908 149.714 206.384 1.00 65.91  ? 318 THR C CA  1 
ATOM   3481 C C   . THR C 3 274 ? 162.180 148.617 205.613 1.00 65.91  ? 318 THR C C   1 
ATOM   3482 O O   . THR C 3 274 ? 162.221 148.560 204.381 1.00 65.91  ? 318 THR C O   1 
ATOM   3483 C CB  . THR C 3 274 ? 161.974 150.403 207.382 1.00 65.91  ? 318 THR C CB  1 
ATOM   3484 O OG1 . THR C 3 274 ? 161.514 149.448 208.346 1.00 65.91  ? 318 THR C OG1 1 
ATOM   3485 C CG2 . THR C 3 274 ? 160.780 151.007 206.670 1.00 65.91  ? 318 THR C CG2 1 
ATOM   3486 N N   . GLU C 3 275 ? 161.505 147.737 206.354 1.00 77.47  ? 319 GLU C N   1 
ATOM   3487 C CA  . GLU C 3 275 ? 160.848 146.598 205.722 1.00 77.47  ? 319 GLU C CA  1 
ATOM   3488 C C   . GLU C 3 275 ? 159.575 147.003 204.990 1.00 77.47  ? 319 GLU C C   1 
ATOM   3489 O O   . GLU C 3 275 ? 159.126 146.284 204.091 1.00 77.47  ? 319 GLU C O   1 
ATOM   3490 C CB  . GLU C 3 275 ? 160.538 145.526 206.767 1.00 77.47  ? 319 GLU C CB  1 
ATOM   3491 C CG  . GLU C 3 275 ? 159.564 145.972 207.849 1.00 77.47  ? 319 GLU C CG  1 
ATOM   3492 C CD  . GLU C 3 275 ? 158.127 145.613 207.525 1.00 77.47  ? 319 GLU C CD  1 
ATOM   3493 O OE1 . GLU C 3 275 ? 157.909 144.803 206.600 1.00 77.47  ? 319 GLU C OE1 1 
ATOM   3494 O OE2 . GLU C 3 275 ? 157.215 146.142 208.195 1.00 77.47  ? 319 GLU C OE2 1 
ATOM   3495 N N   . ASP C 3 276 ? 158.980 148.138 205.353 1.00 78.20  ? 320 ASP C N   1 
ATOM   3496 C CA  . ASP C 3 276 ? 157.680 148.532 204.824 1.00 78.20  ? 320 ASP C CA  1 
ATOM   3497 C C   . ASP C 3 276 ? 157.738 149.744 203.903 1.00 78.20  ? 320 ASP C C   1 
ATOM   3498 O O   . ASP C 3 276 ? 157.049 149.765 202.879 1.00 78.20  ? 320 ASP C O   1 
ATOM   3499 C CB  . ASP C 3 276 ? 156.711 148.819 205.975 1.00 78.20  ? 320 ASP C CB  1 
ATOM   3500 C CG  . ASP C 3 276 ? 155.261 148.678 205.564 1.00 78.20  ? 320 ASP C CG  1 
ATOM   3501 O OD1 . ASP C 3 276 ? 155.007 148.264 204.413 1.00 78.20  ? 320 ASP C OD1 1 
ATOM   3502 O OD2 . ASP C 3 276 ? 154.375 148.980 206.390 1.00 78.20  ? 320 ASP C OD2 1 
ATOM   3503 N N   . ASN C 3 277 ? 158.540 150.752 204.233 1.00 72.41  ? 321 ASN C N   1 
ATOM   3504 C CA  . ASN C 3 277 ? 158.552 152.004 203.487 1.00 72.41  ? 321 ASN C CA  1 
ATOM   3505 C C   . ASN C 3 277 ? 159.997 152.462 203.325 1.00 72.41  ? 321 ASN C C   1 
ATOM   3506 O O   . ASN C 3 277 ? 160.943 151.704 203.555 1.00 72.41  ? 321 ASN C O   1 
ATOM   3507 C CB  . ASN C 3 277 ? 157.691 153.062 204.189 1.00 72.41  ? 321 ASN C CB  1 
ATOM   3508 C CG  . ASN C 3 277 ? 156.209 152.852 203.959 1.00 72.41  ? 321 ASN C CG  1 
ATOM   3509 O OD1 . ASN C 3 277 ? 155.620 153.443 203.054 1.00 72.41  ? 321 ASN C OD1 1 
ATOM   3510 N ND2 . ASN C 3 277 ? 155.596 152.009 204.781 1.00 72.41  ? 321 ASN C ND2 1 
ATOM   3511 N N   . ILE C 3 278 ? 160.162 153.715 202.912 1.00 62.18  ? 322 ILE C N   1 
ATOM   3512 C CA  . ILE C 3 278 ? 161.480 154.312 202.722 1.00 62.18  ? 322 ILE C CA  1 
ATOM   3513 C C   . ILE C 3 278 ? 161.401 155.780 203.119 1.00 62.18  ? 322 ILE C C   1 
ATOM   3514 O O   . ILE C 3 278 ? 160.411 156.459 202.829 1.00 62.18  ? 322 ILE C O   1 
ATOM   3515 C CB  . ILE C 3 278 ? 161.977 154.150 201.270 1.00 62.18  ? 322 ILE C CB  1 
ATOM   3516 C CG1 . ILE C 3 278 ? 163.365 154.772 201.099 1.00 62.18  ? 322 ILE C CG1 1 
ATOM   3517 C CG2 . ILE C 3 278 ? 160.987 154.751 200.284 1.00 62.18  ? 322 ILE C CG2 1 
ATOM   3518 C CD1 . ILE C 3 278 ? 164.031 154.421 199.790 1.00 62.18  ? 322 ILE C CD1 1 
ATOM   3519 N N   . PHE C 3 279 ? 162.435 156.263 203.804 1.00 61.75  ? 323 PHE C N   1 
ATOM   3520 C CA  . PHE C 3 279 ? 162.516 157.652 204.226 1.00 61.75  ? 323 PHE C CA  1 
ATOM   3521 C C   . PHE C 3 279 ? 163.891 158.204 203.886 1.00 61.75  ? 323 PHE C C   1 
ATOM   3522 O O   . PHE C 3 279 ? 164.880 157.467 203.847 1.00 61.75  ? 323 PHE C O   1 
ATOM   3523 C CB  . PHE C 3 279 ? 162.255 157.803 205.728 1.00 61.75  ? 323 PHE C CB  1 
ATOM   3524 C CG  . PHE C 3 279 ? 160.975 157.172 206.185 1.00 61.75  ? 323 PHE C CG  1 
ATOM   3525 C CD1 . PHE C 3 279 ? 159.767 157.822 206.009 1.00 61.75  ? 323 PHE C CD1 1 
ATOM   3526 C CD2 . PHE C 3 279 ? 160.980 155.930 206.794 1.00 61.75  ? 323 PHE C CD2 1 
ATOM   3527 C CE1 . PHE C 3 279 ? 158.587 157.244 206.429 1.00 61.75  ? 323 PHE C CE1 1 
ATOM   3528 C CE2 . PHE C 3 279 ? 159.804 155.347 207.218 1.00 61.75  ? 323 PHE C CE2 1 
ATOM   3529 C CZ  . PHE C 3 279 ? 158.605 156.005 207.035 1.00 61.75  ? 323 PHE C CZ  1 
ATOM   3530 N N   . GLY C 3 280 ? 163.947 159.507 203.641 1.00 54.51  ? 324 GLY C N   1 
ATOM   3531 C CA  . GLY C 3 280 ? 165.214 160.132 203.311 1.00 54.51  ? 324 GLY C CA  1 
ATOM   3532 C C   . GLY C 3 280 ? 165.064 161.628 203.162 1.00 54.51  ? 324 GLY C C   1 
ATOM   3533 O O   . GLY C 3 280 ? 163.955 162.169 203.150 1.00 54.51  ? 324 GLY C O   1 
ATOM   3534 N N   . THR C 3 281 ? 166.212 162.291 203.047 1.00 53.95  ? 325 THR C N   1 
ATOM   3535 C CA  . THR C 3 281 ? 166.277 163.731 202.859 1.00 53.95  ? 325 THR C CA  1 
ATOM   3536 C C   . THR C 3 281 ? 167.320 164.031 201.791 1.00 53.95  ? 325 THR C C   1 
ATOM   3537 O O   . THR C 3 281 ? 167.889 163.123 201.179 1.00 53.95  ? 325 THR C O   1 
ATOM   3538 C CB  . THR C 3 281 ? 166.601 164.453 204.172 1.00 53.95  ? 325 THR C CB  1 
ATOM   3539 O OG1 . THR C 3 281 ? 166.500 165.869 203.978 1.00 53.95  ? 325 THR C OG1 1 
ATOM   3540 C CG2 . THR C 3 281 ? 168.006 164.108 204.639 1.00 53.95  ? 325 THR C CG2 1 
ATOM   3541 N N   . VAL C 3 282 ? 167.572 165.318 201.565 1.00 48.54  ? 326 VAL C N   1 
ATOM   3542 C CA  . VAL C 3 282 ? 168.513 165.775 200.552 1.00 48.54  ? 326 VAL C CA  1 
ATOM   3543 C C   . VAL C 3 282 ? 169.532 166.695 201.206 1.00 48.54  ? 326 VAL C C   1 
ATOM   3544 O O   . VAL C 3 282 ? 169.179 167.528 202.048 1.00 48.54  ? 326 VAL C O   1 
ATOM   3545 C CB  . VAL C 3 282 ? 167.792 166.496 199.394 1.00 48.54  ? 326 VAL C CB  1 
ATOM   3546 C CG1 . VAL C 3 282 ? 168.781 166.888 198.317 1.00 48.54  ? 326 VAL C CG1 1 
ATOM   3547 C CG2 . VAL C 3 282 ? 166.697 165.616 198.819 1.00 48.54  ? 326 VAL C CG2 1 
ATOM   3548 N N   . ILE C 3 283 ? 170.796 166.541 200.821 1.00 51.32  ? 327 ILE C N   1 
ATOM   3549 C CA  . ILE C 3 283 ? 171.875 167.398 201.294 1.00 51.32  ? 327 ILE C CA  1 
ATOM   3550 C C   . ILE C 3 283 ? 172.526 168.066 200.090 1.00 51.32  ? 327 ILE C C   1 
ATOM   3551 O O   . ILE C 3 283 ? 172.627 167.478 199.008 1.00 51.32  ? 327 ILE C O   1 
ATOM   3552 C CB  . ILE C 3 283 ? 172.912 166.608 202.127 1.00 51.32  ? 327 ILE C CB  1 
ATOM   3553 C CG1 . ILE C 3 283 ? 173.899 167.556 202.809 1.00 51.32  ? 327 ILE C CG1 1 
ATOM   3554 C CG2 . ILE C 3 283 ? 173.643 165.594 201.267 1.00 51.32  ? 327 ILE C CG2 1 
ATOM   3555 C CD1 . ILE C 3 283 ? 173.358 168.192 204.066 1.00 51.32  ? 327 ILE C CD1 1 
ATOM   3556 N N   . PHE C 3 284 ? 172.951 169.313 200.278 1.00 55.60  ? 328 PHE C N   1 
ATOM   3557 C CA  . PHE C 3 284 ? 173.550 170.117 199.214 1.00 55.60  ? 328 PHE C CA  1 
ATOM   3558 C C   . PHE C 3 284 ? 174.957 170.517 199.646 1.00 55.60  ? 328 PHE C C   1 
ATOM   3559 O O   . PHE C 3 284 ? 175.125 171.336 200.555 1.00 55.60  ? 328 PHE C O   1 
ATOM   3560 C CB  . PHE C 3 284 ? 172.700 171.347 198.909 1.00 55.60  ? 328 PHE C CB  1 
ATOM   3561 C CG  . PHE C 3 284 ? 171.286 171.028 198.521 1.00 55.60  ? 328 PHE C CG  1 
ATOM   3562 C CD1 . PHE C 3 284 ? 170.968 170.703 197.215 1.00 55.60  ? 328 PHE C CD1 1 
ATOM   3563 C CD2 . PHE C 3 284 ? 170.271 171.066 199.462 1.00 55.60  ? 328 PHE C CD2 1 
ATOM   3564 C CE1 . PHE C 3 284 ? 169.667 170.414 196.855 1.00 55.60  ? 328 PHE C CE1 1 
ATOM   3565 C CE2 . PHE C 3 284 ? 168.968 170.779 199.107 1.00 55.60  ? 328 PHE C CE2 1 
ATOM   3566 C CZ  . PHE C 3 284 ? 168.665 170.452 197.802 1.00 55.60  ? 328 PHE C CZ  1 
ATOM   3567 N N   . ALA C 3 285 ? 175.965 169.943 198.995 1.00 61.02  ? 329 ALA C N   1 
ATOM   3568 C CA  . ALA C 3 285 ? 177.357 170.273 199.269 1.00 61.02  ? 329 ALA C CA  1 
ATOM   3569 C C   . ALA C 3 285 ? 177.856 171.249 198.211 1.00 61.02  ? 329 ALA C C   1 
ATOM   3570 O O   . ALA C 3 285 ? 177.868 170.925 197.018 1.00 61.02  ? 329 ALA C O   1 
ATOM   3571 C CB  . ALA C 3 285 ? 178.219 169.012 199.292 1.00 61.02  ? 329 ALA C CB  1 
ATOM   3572 N N   . GLY C 3 286 ? 178.270 172.437 198.645 1.00 67.52  ? 330 GLY C N   1 
ATOM   3573 C CA  . GLY C 3 286 ? 178.695 173.467 197.719 1.00 67.52  ? 330 GLY C CA  1 
ATOM   3574 C C   . GLY C 3 286 ? 179.965 174.183 198.127 1.00 67.52  ? 330 GLY C C   1 
ATOM   3575 O O   . GLY C 3 286 ? 180.646 173.772 199.071 1.00 67.52  ? 330 GLY C O   1 
ATOM   3576 N N   . TYR C 3 287 ? 180.291 175.259 197.424 1.00 70.69  ? 331 TYR C N   1 
ATOM   3577 C CA  . TYR C 3 287 ? 181.510 176.020 197.629 1.00 70.69  ? 331 TYR C CA  1 
ATOM   3578 C C   . TYR C 3 287 ? 181.190 177.489 197.875 1.00 70.69  ? 331 TYR C C   1 
ATOM   3579 O O   . TYR C 3 287 ? 180.099 177.962 197.536 1.00 70.69  ? 331 TYR C O   1 
ATOM   3580 C CB  . TYR C 3 287 ? 182.435 175.895 196.409 1.00 70.69  ? 331 TYR C CB  1 
ATOM   3581 C CG  . TYR C 3 287 ? 183.091 174.543 196.258 1.00 70.69  ? 331 TYR C CG  1 
ATOM   3582 C CD1 . TYR C 3 287 ? 184.273 174.246 196.922 1.00 70.69  ? 331 TYR C CD1 1 
ATOM   3583 C CD2 . TYR C 3 287 ? 182.535 173.567 195.444 1.00 70.69  ? 331 TYR C CD2 1 
ATOM   3584 C CE1 . TYR C 3 287 ? 184.879 173.012 196.785 1.00 70.69  ? 331 TYR C CE1 1 
ATOM   3585 C CE2 . TYR C 3 287 ? 183.133 172.330 195.300 1.00 70.69  ? 331 TYR C CE2 1 
ATOM   3586 C CZ  . TYR C 3 287 ? 184.304 172.059 195.973 1.00 70.69  ? 331 TYR C CZ  1 
ATOM   3587 O OH  . TYR C 3 287 ? 184.904 170.828 195.833 1.00 70.69  ? 331 TYR C OH  1 
ATOM   3588 N N   . PRO C 3 288 ? 182.114 178.238 198.470 1.00 72.34  ? 332 PRO C N   1 
ATOM   3589 C CA  . PRO C 3 288 ? 181.936 179.689 198.580 1.00 72.34  ? 332 PRO C CA  1 
ATOM   3590 C C   . PRO C 3 288 ? 181.996 180.342 197.211 1.00 72.34  ? 332 PRO C C   1 
ATOM   3591 O O   . PRO C 3 288 ? 182.527 179.753 196.258 1.00 72.34  ? 332 PRO C O   1 
ATOM   3592 C CB  . PRO C 3 288 ? 183.119 180.124 199.461 1.00 72.34  ? 332 PRO C CB  1 
ATOM   3593 C CG  . PRO C 3 288 ? 184.127 179.039 199.307 1.00 72.34  ? 332 PRO C CG  1 
ATOM   3594 C CD  . PRO C 3 288 ? 183.330 177.781 199.165 1.00 72.34  ? 332 PRO C CD  1 
ATOM   3595 N N   . PRO C 3 289 ? 181.467 181.557 197.068 1.00 71.19  ? 333 PRO C N   1 
ATOM   3596 C CA  . PRO C 3 289 ? 181.455 182.199 195.750 1.00 71.19  ? 333 PRO C CA  1 
ATOM   3597 C C   . PRO C 3 289 ? 182.811 182.793 195.406 1.00 71.19  ? 333 PRO C C   1 
ATOM   3598 O O   . PRO C 3 289 ? 183.506 183.351 196.259 1.00 71.19  ? 333 PRO C O   1 
ATOM   3599 C CB  . PRO C 3 289 ? 180.392 183.291 195.903 1.00 71.19  ? 333 PRO C CB  1 
ATOM   3600 C CG  . PRO C 3 289 ? 180.463 183.660 197.343 1.00 71.19  ? 333 PRO C CG  1 
ATOM   3601 C CD  . PRO C 3 289 ? 180.878 182.422 198.105 1.00 71.19  ? 333 PRO C CD  1 
ATOM   3602 N N   . ASP C 3 290 ? 183.183 182.665 194.136 1.00 79.53  ? 334 ASP C N   1 
ATOM   3603 C CA  . ASP C 3 290 ? 184.465 183.178 193.678 1.00 79.53  ? 334 ASP C CA  1 
ATOM   3604 C C   . ASP C 3 290 ? 184.406 184.691 193.501 1.00 79.53  ? 334 ASP C C   1 
ATOM   3605 O O   . ASP C 3 290 ? 183.347 185.271 193.249 1.00 79.53  ? 334 ASP C O   1 
ATOM   3606 C CB  . ASP C 3 290 ? 184.865 182.511 192.362 1.00 79.53  ? 334 ASP C CB  1 
ATOM   3607 C CG  . ASP C 3 290 ? 186.326 182.729 192.018 1.00 79.53  ? 334 ASP C CG  1 
ATOM   3608 O OD1 . ASP C 3 290 ? 186.776 182.206 190.976 1.00 79.53  ? 334 ASP C OD1 1 
ATOM   3609 O OD2 . ASP C 3 290 ? 187.027 183.417 192.789 1.00 79.53  ? 334 ASP C OD2 1 
ATOM   3610 N N   . THR C 3 291 ? 185.561 185.326 193.640 1.00 78.20  ? 335 THR C N   1 
ATOM   3611 C CA  . THR C 3 291 ? 185.647 186.769 193.457 1.00 78.20  ? 335 THR C CA  1 
ATOM   3612 C C   . THR C 3 291 ? 185.407 187.116 191.992 1.00 78.20  ? 335 THR C C   1 
ATOM   3613 O O   . THR C 3 291 ? 185.983 186.471 191.108 1.00 78.20  ? 335 THR C O   1 
ATOM   3614 C CB  . THR C 3 291 ? 187.015 187.281 193.907 1.00 78.20  ? 335 THR C CB  1 
ATOM   3615 O OG1 . THR C 3 291 ? 187.188 187.020 195.305 1.00 78.20  ? 335 THR C OG1 1 
ATOM   3616 C CG2 . THR C 3 291 ? 187.142 188.775 193.655 1.00 78.20  ? 335 THR C CG2 1 
ATOM   3617 N N   . PRO C 3 292 ? 184.560 188.101 191.692 1.00 79.63  ? 336 PRO C N   1 
ATOM   3618 C CA  . PRO C 3 292 ? 184.341 188.483 190.292 1.00 79.63  ? 336 PRO C CA  1 
ATOM   3619 C C   . PRO C 3 292 ? 185.636 188.927 189.629 1.00 79.63  ? 336 PRO C C   1 
ATOM   3620 O O   . PRO C 3 292 ? 186.427 189.678 190.205 1.00 79.63  ? 336 PRO C O   1 
ATOM   3621 C CB  . PRO C 3 292 ? 183.334 189.633 190.392 1.00 79.63  ? 336 PRO C CB  1 
ATOM   3622 C CG  . PRO C 3 292 ? 182.635 189.403 191.690 1.00 79.63  ? 336 PRO C CG  1 
ATOM   3623 C CD  . PRO C 3 292 ? 183.667 188.826 192.611 1.00 79.63  ? 336 PRO C CD  1 
ATOM   3624 N N   . GLN C 3 293 ? 185.847 188.453 188.404 1.00 82.81  ? 337 GLN C N   1 
ATOM   3625 C CA  . GLN C 3 293 ? 187.086 188.674 187.676 1.00 82.81  ? 337 GLN C CA  1 
ATOM   3626 C C   . GLN C 3 293 ? 186.813 189.396 186.365 1.00 82.81  ? 337 GLN C C   1 
ATOM   3627 O O   . GLN C 3 293 ? 185.748 189.239 185.759 1.00 82.81  ? 337 GLN C O   1 
ATOM   3628 C CB  . GLN C 3 293 ? 187.800 187.348 187.396 1.00 82.81  ? 337 GLN C CB  1 
ATOM   3629 C CG  . GLN C 3 293 ? 188.005 186.487 188.628 1.00 82.81  ? 337 GLN C CG  1 
ATOM   3630 C CD  . GLN C 3 293 ? 188.275 185.038 188.286 1.00 82.81  ? 337 GLN C CD  1 
ATOM   3631 O OE1 . GLN C 3 293 ? 188.396 184.677 187.116 1.00 82.81  ? 337 GLN C OE1 1 
ATOM   3632 N NE2 . GLN C 3 293 ? 188.369 184.197 189.308 1.00 82.81  ? 337 GLN C NE2 1 
ATOM   3633 N N   . GLN C 3 294 ? 187.796 190.190 185.934 1.00 84.43  ? 338 GLN C N   1 
ATOM   3634 C CA  . GLN C 3 294 ? 187.744 190.925 184.671 1.00 84.43  ? 338 GLN C CA  1 
ATOM   3635 C C   . GLN C 3 294 ? 186.525 191.847 184.619 1.00 84.43  ? 338 GLN C C   1 
ATOM   3636 O O   . GLN C 3 294 ? 185.628 191.699 183.787 1.00 84.43  ? 338 GLN C O   1 
ATOM   3637 C CB  . GLN C 3 294 ? 187.764 189.964 183.478 1.00 84.43  ? 338 GLN C CB  1 
ATOM   3638 C CG  . GLN C 3 294 ? 189.010 189.101 183.400 1.00 84.43  ? 338 GLN C CG  1 
ATOM   3639 C CD  . GLN C 3 294 ? 189.055 188.256 182.144 1.00 84.43  ? 338 GLN C CD  1 
ATOM   3640 O OE1 . GLN C 3 294 ? 188.302 188.489 181.198 1.00 84.43  ? 338 GLN C OE1 1 
ATOM   3641 N NE2 . GLN C 3 294 ? 189.940 187.267 182.127 1.00 84.43  ? 338 GLN C NE2 1 
ATOM   3642 N N   . LEU C 3 295 ? 186.509 192.811 185.534 1.00 85.86  ? 339 LEU C N   1 
ATOM   3643 C CA  . LEU C 3 295 ? 185.439 193.797 185.605 1.00 85.86  ? 339 LEU C CA  1 
ATOM   3644 C C   . LEU C 3 295 ? 185.833 195.021 184.787 1.00 85.86  ? 339 LEU C C   1 
ATOM   3645 O O   . LEU C 3 295 ? 186.863 195.647 185.057 1.00 85.86  ? 339 LEU C O   1 
ATOM   3646 C CB  . LEU C 3 295 ? 185.155 194.181 187.056 1.00 85.86  ? 339 LEU C CB  1 
ATOM   3647 C CG  . LEU C 3 295 ? 183.943 195.082 187.302 1.00 85.86  ? 339 LEU C CG  1 
ATOM   3648 C CD1 . LEU C 3 295 ? 182.682 194.449 186.744 1.00 85.86  ? 339 LEU C CD1 1 
ATOM   3649 C CD2 . LEU C 3 295 ? 183.787 195.373 188.785 1.00 85.86  ? 339 LEU C CD2 1 
ATOM   3650 N N   . ASN C 3 296 ? 185.021 195.353 183.785 1.00 89.67  ? 340 ASN C N   1 
ATOM   3651 C CA  . ASN C 3 296 ? 185.265 196.504 182.928 1.00 89.67  ? 340 ASN C CA  1 
ATOM   3652 C C   . ASN C 3 296 ? 183.935 197.127 182.532 1.00 89.67  ? 340 ASN C C   1 
ATOM   3653 O O   . ASN C 3 296 ? 182.949 196.418 182.317 1.00 89.67  ? 340 ASN C O   1 
ATOM   3654 C CB  . ASN C 3 296 ? 186.053 196.117 181.671 1.00 89.67  ? 340 ASN C CB  1 
ATOM   3655 C CG  . ASN C 3 296 ? 187.421 195.552 181.992 1.00 89.67  ? 340 ASN C CG  1 
ATOM   3656 O OD1 . ASN C 3 296 ? 188.378 196.296 182.207 1.00 89.67  ? 340 ASN C OD1 1 
ATOM   3657 N ND2 . ASN C 3 296 ? 187.521 194.229 182.026 1.00 89.67  ? 340 ASN C ND2 1 
ATOM   3658 N N   . CYS C 3 297 ? 183.916 198.455 182.438 1.00 92.72  ? 341 CYS C N   1 
ATOM   3659 C CA  . CYS C 3 297 ? 182.716 199.199 182.082 1.00 92.72  ? 341 CYS C CA  1 
ATOM   3660 C C   . CYS C 3 297 ? 183.032 200.175 180.959 1.00 92.72  ? 341 CYS C C   1 
ATOM   3661 O O   . CYS C 3 297 ? 184.106 200.784 180.938 1.00 92.72  ? 341 CYS C O   1 
ATOM   3662 C CB  . CYS C 3 297 ? 182.150 199.955 183.291 1.00 92.72  ? 341 CYS C CB  1 
ATOM   3663 S SG  . CYS C 3 297 ? 182.014 198.963 184.797 1.00 92.72  ? 341 CYS C SG  1 
ATOM   3664 N N   . GLU C 3 298 ? 182.092 200.319 180.029 1.00 89.58  ? 342 GLU C N   1 
ATOM   3665 C CA  . GLU C 3 298 ? 182.245 201.225 178.901 1.00 89.58  ? 342 GLU C CA  1 
ATOM   3666 C C   . GLU C 3 298 ? 180.870 201.753 178.514 1.00 89.58  ? 342 GLU C C   1 
ATOM   3667 O O   . GLU C 3 298 ? 179.843 201.310 179.036 1.00 89.58  ? 342 GLU C O   1 
ATOM   3668 C CB  . GLU C 3 298 ? 182.933 200.529 177.724 1.00 89.58  ? 342 GLU C CB  1 
ATOM   3669 C CG  . GLU C 3 298 ? 182.168 199.337 177.179 1.00 89.58  ? 342 GLU C CG  1 
ATOM   3670 C CD  . GLU C 3 298 ? 182.835 198.726 175.965 1.00 89.58  ? 342 GLU C CD  1 
ATOM   3671 O OE1 . GLU C 3 298 ? 182.228 197.832 175.339 1.00 89.58  ? 342 GLU C OE1 1 
ATOM   3672 O OE2 . GLU C 3 298 ? 183.967 199.139 175.637 1.00 89.58  ? 342 GLU C OE2 1 
ATOM   3673 N N   . THR C 3 299 ? 180.853 202.707 177.585 1.00 87.33  ? 343 THR C N   1 
ATOM   3674 C CA  . THR C 3 299 ? 179.622 203.356 177.158 1.00 87.33  ? 343 THR C CA  1 
ATOM   3675 C C   . THR C 3 299 ? 179.542 203.386 175.639 1.00 87.33  ? 343 THR C C   1 
ATOM   3676 O O   . THR C 3 299 ? 180.561 203.442 174.946 1.00 87.33  ? 343 THR C O   1 
ATOM   3677 C CB  . THR C 3 299 ? 179.520 204.788 177.697 1.00 87.33  ? 343 THR C CB  1 
ATOM   3678 O OG1 . THR C 3 299 ? 180.756 205.476 177.468 1.00 87.33  ? 343 THR C OG1 1 
ATOM   3679 C CG2 . THR C 3 299 ? 179.215 204.777 179.186 1.00 87.33  ? 343 THR C CG2 1 
ATOM   3680 N N   . HIS C 3 300 ? 178.310 203.353 175.131 1.00 88.79  ? 344 HIS C N   1 
ATOM   3681 C CA  . HIS C 3 300 ? 178.048 203.428 173.701 1.00 88.79  ? 344 HIS C CA  1 
ATOM   3682 C C   . HIS C 3 300 ? 177.402 204.733 173.265 1.00 88.79  ? 344 HIS C C   1 
ATOM   3683 O O   . HIS C 3 300 ? 177.766 205.264 172.215 1.00 88.79  ? 344 HIS C O   1 
ATOM   3684 C CB  . HIS C 3 300 ? 177.149 202.264 173.261 1.00 88.79  ? 344 HIS C CB  1 
ATOM   3685 C CG  . HIS C 3 300 ? 177.832 200.932 173.282 1.00 88.79  ? 344 HIS C CG  1 
ATOM   3686 N ND1 . HIS C 3 300 ? 178.943 200.653 172.517 1.00 88.79  ? 344 HIS C ND1 1 
ATOM   3687 C CD2 . HIS C 3 300 ? 177.556 199.799 173.971 1.00 88.79  ? 344 HIS C CD2 1 
ATOM   3688 C CE1 . HIS C 3 300 ? 179.325 199.408 172.736 1.00 88.79  ? 344 HIS C CE1 1 
ATOM   3689 N NE2 . HIS C 3 300 ? 178.500 198.867 173.614 1.00 88.79  ? 344 HIS C NE2 1 
ATOM   3690 N N   . ASP C 3 301 ? 176.456 205.263 174.045 1.00 90.32  ? 345 ASP C N   1 
ATOM   3691 C CA  . ASP C 3 301 ? 175.777 206.507 173.702 1.00 90.32  ? 345 ASP C CA  1 
ATOM   3692 C C   . ASP C 3 301 ? 175.802 207.507 174.852 1.00 90.32  ? 345 ASP C C   1 
ATOM   3693 O O   . ASP C 3 301 ? 175.023 208.466 174.847 1.00 90.32  ? 345 ASP C O   1 
ATOM   3694 C CB  . ASP C 3 301 ? 174.333 206.235 173.272 1.00 90.32  ? 345 ASP C CB  1 
ATOM   3695 C CG  . ASP C 3 301 ? 173.535 205.514 174.339 1.00 90.32  ? 345 ASP C CG  1 
ATOM   3696 O OD1 . ASP C 3 301 ? 174.143 204.758 175.125 1.00 90.32  ? 345 ASP C OD1 1 
ATOM   3697 O OD2 . ASP C 3 301 ? 172.302 205.703 174.392 1.00 90.32  ? 345 ASP C OD2 1 
ATOM   3698 N N   . LEU C 3 302 ? 176.677 207.298 175.837 1.00 88.46  ? 346 LEU C N   1 
ATOM   3699 C CA  . LEU C 3 302 ? 176.830 208.199 176.980 1.00 88.46  ? 346 LEU C CA  1 
ATOM   3700 C C   . LEU C 3 302 ? 175.513 208.406 177.725 1.00 88.46  ? 346 LEU C C   1 
ATOM   3701 O O   . LEU C 3 302 ? 175.238 209.495 178.232 1.00 88.46  ? 346 LEU C O   1 
ATOM   3702 C CB  . LEU C 3 302 ? 177.420 209.546 176.552 1.00 88.46  ? 346 LEU C CB  1 
ATOM   3703 C CG  . LEU C 3 302 ? 178.869 209.521 176.061 1.00 88.46  ? 346 LEU C CG  1 
ATOM   3704 C CD1 . LEU C 3 302 ? 179.342 210.920 175.706 1.00 88.46  ? 346 LEU C CD1 1 
ATOM   3705 C CD2 . LEU C 3 302 ? 179.780 208.895 177.102 1.00 88.46  ? 346 LEU C CD2 1 
ATOM   3706 N N   . LYS C 3 303 ? 174.687 207.362 177.791 1.00 94.52  ? 347 LYS C N   1 
ATOM   3707 C CA  . LYS C 3 303 ? 173.427 207.428 178.519 1.00 94.52  ? 347 LYS C CA  1 
ATOM   3708 C C   . LYS C 3 303 ? 173.342 206.297 179.535 1.00 94.52  ? 347 LYS C C   1 
ATOM   3709 O O   . LYS C 3 303 ? 172.786 206.470 180.625 1.00 94.52  ? 347 LYS C O   1 
ATOM   3710 C CB  . LYS C 3 303 ? 172.240 207.368 177.555 1.00 94.52  ? 347 LYS C CB  1 
ATOM   3711 C CG  . LYS C 3 303 ? 172.112 208.580 176.649 1.00 94.52  ? 347 LYS C CG  1 
ATOM   3712 C CD  . LYS C 3 303 ? 170.824 208.530 175.843 1.00 94.52  ? 347 LYS C CD  1 
ATOM   3713 C CE  . LYS C 3 303 ? 170.654 209.781 174.996 1.00 94.52  ? 347 LYS C CE  1 
ATOM   3714 N NZ  . LYS C 3 303 ? 169.373 209.768 174.236 1.00 94.52  ? 347 LYS C NZ  1 
ATOM   3715 N N   . GLU C 3 304 ? 173.890 205.138 179.184 1.00 96.07  ? 348 GLU C N   1 
ATOM   3716 C CA  . GLU C 3 304 ? 173.903 203.976 180.058 1.00 96.07  ? 348 GLU C CA  1 
ATOM   3717 C C   . GLU C 3 304 ? 175.298 203.373 180.073 1.00 96.07  ? 348 GLU C C   1 
ATOM   3718 O O   . GLU C 3 304 ? 176.026 203.423 179.078 1.00 96.07  ? 348 GLU C O   1 
ATOM   3719 C CB  . GLU C 3 304 ? 172.883 202.923 179.610 1.00 96.07  ? 348 GLU C CB  1 
ATOM   3720 C CG  . GLU C 3 304 ? 172.948 202.594 178.130 1.00 96.07  ? 348 GLU C CG  1 
ATOM   3721 C CD  . GLU C 3 304 ? 171.941 201.538 177.724 1.00 96.07  ? 348 GLU C CD  1 
ATOM   3722 O OE1 . GLU C 3 304 ? 172.304 200.639 176.937 1.00 96.07  ? 348 GLU C OE1 1 
ATOM   3723 O OE2 . GLU C 3 304 ? 170.785 201.606 178.193 1.00 96.07  ? 348 GLU C OE2 1 
ATOM   3724 N N   . ILE C 3 305 ? 175.666 202.802 181.216 1.00 92.07  ? 349 ILE C N   1 
ATOM   3725 C CA  . ILE C 3 305 ? 176.972 202.182 181.409 1.00 92.07  ? 349 ILE C CA  1 
ATOM   3726 C C   . ILE C 3 305 ? 176.761 200.686 181.585 1.00 92.07  ? 349 ILE C C   1 
ATOM   3727 O O   . ILE C 3 305 ? 175.986 200.257 182.449 1.00 92.07  ? 349 ILE C O   1 
ATOM   3728 C CB  . ILE C 3 305 ? 177.711 202.779 182.615 1.00 92.07  ? 349 ILE C CB  1 
ATOM   3729 C CG1 . ILE C 3 305 ? 177.669 204.306 182.562 1.00 92.07  ? 349 ILE C CG1 1 
ATOM   3730 C CG2 . ILE C 3 305 ? 179.148 202.288 182.651 1.00 92.07  ? 349 ILE C CG2 1 
ATOM   3731 C CD1 . ILE C 3 305 ? 178.093 204.970 183.852 1.00 92.07  ? 349 ILE C CD1 1 
ATOM   3732 N N   . ILE C 3 306 ? 177.446 199.894 180.766 1.00 91.08  ? 350 ILE C N   1 
ATOM   3733 C CA  . ILE C 3 306 ? 177.394 198.439 180.838 1.00 91.08  ? 350 ILE C CA  1 
ATOM   3734 C C   . ILE C 3 306 ? 178.708 197.949 181.432 1.00 91.08  ? 350 ILE C C   1 
ATOM   3735 O O   . ILE C 3 306 ? 179.790 198.281 180.930 1.00 91.08  ? 350 ILE C O   1 
ATOM   3736 C CB  . ILE C 3 306 ? 177.125 197.810 179.462 1.00 91.08  ? 350 ILE C CB  1 
ATOM   3737 C CG1 . ILE C 3 306 ? 178.080 198.374 178.407 1.00 91.08  ? 350 ILE C CG1 1 
ATOM   3738 C CG2 . ILE C 3 306 ? 175.679 198.032 179.051 1.00 91.08  ? 350 ILE C CG2 1 
ATOM   3739 C CD1 . ILE C 3 306 ? 178.010 197.661 177.076 1.00 91.08  ? 350 ILE C CD1 1 
ATOM   3740 N N   . CYS C 3 307 ? 178.616 197.176 182.510 1.00 93.26  ? 351 CYS C N   1 
ATOM   3741 C CA  . CYS C 3 307 ? 179.780 196.642 183.205 1.00 93.26  ? 351 CYS C CA  1 
ATOM   3742 C C   . CYS C 3 307 ? 179.833 195.136 182.992 1.00 93.26  ? 351 CYS C C   1 
ATOM   3743 O O   . CYS C 3 307 ? 178.894 194.420 183.357 1.00 93.26  ? 351 CYS C O   1 
ATOM   3744 C CB  . CYS C 3 307 ? 179.730 196.978 184.694 1.00 93.26  ? 351 CYS C CB  1 
ATOM   3745 S SG  . CYS C 3 307 ? 180.016 198.723 185.064 1.00 93.26  ? 351 CYS C SG  1 
ATOM   3746 N N   . SER C 3 308 ? 180.928 194.661 182.406 1.00 89.94  ? 352 SER C N   1 
ATOM   3747 C CA  . SER C 3 308 ? 181.104 193.254 182.088 1.00 89.94  ? 352 SER C CA  1 
ATOM   3748 C C   . SER C 3 308 ? 182.066 192.602 183.072 1.00 89.94  ? 352 SER C C   1 
ATOM   3749 O O   . SER C 3 308 ? 183.059 193.205 183.488 1.00 89.94  ? 352 SER C O   1 
ATOM   3750 C CB  . SER C 3 308 ? 181.622 193.075 180.658 1.00 89.94  ? 352 SER C CB  1 
ATOM   3751 O OG  . SER C 3 308 ? 180.920 193.910 179.754 1.00 89.94  ? 352 SER C OG  1 
ATOM   3752 N N   . TRP C 3 309 ? 181.761 191.360 183.439 1.00 90.17  ? 353 TRP C N   1 
ATOM   3753 C CA  . TRP C 3 309 ? 182.601 190.609 184.361 1.00 90.17  ? 353 TRP C CA  1 
ATOM   3754 C C   . TRP C 3 309 ? 182.429 189.123 184.082 1.00 90.17  ? 353 TRP C C   1 
ATOM   3755 O O   . TRP C 3 309 ? 181.517 188.705 183.365 1.00 90.17  ? 353 TRP C O   1 
ATOM   3756 C CB  . TRP C 3 309 ? 182.268 190.938 185.822 1.00 90.17  ? 353 TRP C CB  1 
ATOM   3757 C CG  . TRP C 3 309 ? 181.076 190.203 186.372 1.00 90.17  ? 353 TRP C CG  1 
ATOM   3758 C CD1 . TRP C 3 309 ? 181.066 188.956 186.930 1.00 90.17  ? 353 TRP C CD1 1 
ATOM   3759 C CD2 . TRP C 3 309 ? 179.727 190.680 186.437 1.00 90.17  ? 353 TRP C CD2 1 
ATOM   3760 N NE1 . TRP C 3 309 ? 179.793 188.625 187.325 1.00 90.17  ? 353 TRP C NE1 1 
ATOM   3761 C CE2 . TRP C 3 309 ? 178.953 189.667 187.036 1.00 90.17  ? 353 TRP C CE2 1 
ATOM   3762 C CE3 . TRP C 3 309 ? 179.098 191.864 186.042 1.00 90.17  ? 353 TRP C CE3 1 
ATOM   3763 C CZ2 . TRP C 3 309 ? 177.584 189.802 187.249 1.00 90.17  ? 353 TRP C CZ2 1 
ATOM   3764 C CZ3 . TRP C 3 309 ? 177.738 191.996 186.255 1.00 90.17  ? 353 TRP C CZ3 1 
ATOM   3765 C CH2 . TRP C 3 309 ? 176.997 190.970 186.852 1.00 90.17  ? 353 TRP C CH2 1 
ATOM   3766 N N   . ASN C 3 310 ? 183.326 188.327 184.666 1.00 88.09  ? 354 ASN C N   1 
ATOM   3767 C CA  . ASN C 3 310 ? 183.287 186.880 184.565 1.00 88.09  ? 354 ASN C CA  1 
ATOM   3768 C C   . ASN C 3 310 ? 182.970 186.260 185.920 1.00 88.09  ? 354 ASN C C   1 
ATOM   3769 O O   . ASN C 3 310 ? 183.536 186.675 186.938 1.00 88.09  ? 354 ASN C O   1 
ATOM   3770 C CB  . ASN C 3 310 ? 184.621 186.322 184.055 1.00 88.09  ? 354 ASN C CB  1 
ATOM   3771 C CG  . ASN C 3 310 ? 184.906 186.717 182.622 1.00 88.09  ? 354 ASN C CG  1 
ATOM   3772 O OD1 . ASN C 3 310 ? 183.989 186.901 181.823 1.00 88.09  ? 354 ASN C OD1 1 
ATOM   3773 N ND2 . ASN C 3 310 ? 186.184 186.848 182.288 1.00 88.09  ? 354 ASN C ND2 1 
ATOM   3774 N N   . PRO C 3 311 ? 182.075 185.270 185.968 1.00 81.86  ? 355 PRO C N   1 
ATOM   3775 C CA  . PRO C 3 311 ? 181.734 184.656 187.260 1.00 81.86  ? 355 PRO C CA  1 
ATOM   3776 C C   . PRO C 3 311 ? 182.876 183.875 187.882 1.00 81.86  ? 355 PRO C C   1 
ATOM   3777 O O   . PRO C 3 311 ? 182.848 183.633 189.095 1.00 81.86  ? 355 PRO C O   1 
ATOM   3778 C CB  . PRO C 3 311 ? 180.556 183.737 186.912 1.00 81.86  ? 355 PRO C CB  1 
ATOM   3779 C CG  . PRO C 3 311 ? 180.745 183.424 185.467 1.00 81.86  ? 355 PRO C CG  1 
ATOM   3780 C CD  . PRO C 3 311 ? 181.336 184.660 184.850 1.00 81.86  ? 355 PRO C CD  1 
ATOM   3781 N N   . GLY C 3 312 ? 183.874 183.475 187.101 1.00 82.29  ? 356 GLY C N   1 
ATOM   3782 C CA  . GLY C 3 312 ? 185.007 182.749 187.638 1.00 82.29  ? 356 GLY C CA  1 
ATOM   3783 C C   . GLY C 3 312 ? 184.733 181.274 187.845 1.00 82.29  ? 356 GLY C C   1 
ATOM   3784 O O   . GLY C 3 312 ? 184.101 180.627 187.006 1.00 82.29  ? 356 GLY C O   1 
ATOM   3785 N N   . ARG C 3 313 ? 185.206 180.734 188.964 1.00 76.70  ? 357 ARG C N   1 
ATOM   3786 C CA  . ARG C 3 313 ? 185.022 179.319 189.250 1.00 76.70  ? 357 ARG C CA  1 
ATOM   3787 C C   . ARG C 3 313 ? 183.575 179.035 189.633 1.00 76.70  ? 357 ARG C C   1 
ATOM   3788 O O   . ARG C 3 313 ? 182.929 179.830 190.321 1.00 76.70  ? 357 ARG C O   1 
ATOM   3789 C CB  . ARG C 3 313 ? 185.966 178.884 190.370 1.00 76.70  ? 357 ARG C CB  1 
ATOM   3790 C CG  . ARG C 3 313 ? 186.333 177.413 190.342 1.00 76.70  ? 357 ARG C CG  1 
ATOM   3791 C CD  . ARG C 3 313 ? 185.525 176.639 191.361 1.00 76.70  ? 357 ARG C CD  1 
ATOM   3792 N NE  . ARG C 3 313 ? 185.475 177.335 192.643 1.00 76.70  ? 357 ARG C NE  1 
ATOM   3793 C CZ  . ARG C 3 313 ? 184.666 177.000 193.640 1.00 76.70  ? 357 ARG C CZ  1 
ATOM   3794 N NH1 . ARG C 3 313 ? 183.838 175.974 193.504 1.00 76.70  ? 357 ARG C NH1 1 
ATOM   3795 N NH2 . ARG C 3 313 ? 184.684 177.689 194.773 1.00 76.70  ? 357 ARG C NH2 1 
ATOM   3796 N N   . VAL C 3 314 ? 183.065 177.890 189.178 1.00 73.50  ? 358 VAL C N   1 
ATOM   3797 C CA  . VAL C 3 314 ? 181.667 177.544 189.404 1.00 73.50  ? 358 VAL C CA  1 
ATOM   3798 C C   . VAL C 3 314 ? 181.448 177.202 190.873 1.00 73.50  ? 358 VAL C C   1 
ATOM   3799 O O   . VAL C 3 314 ? 182.290 176.561 191.516 1.00 73.50  ? 358 VAL C O   1 
ATOM   3800 C CB  . VAL C 3 314 ? 181.252 176.382 188.483 1.00 73.50  ? 358 VAL C CB  1 
ATOM   3801 C CG1 . VAL C 3 314 ? 182.172 175.186 188.677 1.00 73.50  ? 358 VAL C CG1 1 
ATOM   3802 C CG2 . VAL C 3 314 ? 179.799 175.995 188.720 1.00 73.50  ? 358 VAL C CG2 1 
ATOM   3803 N N   . THR C 3 315 ? 180.314 177.642 191.415 1.00 71.85  ? 359 THR C N   1 
ATOM   3804 C CA  . THR C 3 315 ? 179.970 177.392 192.808 1.00 71.85  ? 359 THR C CA  1 
ATOM   3805 C C   . THR C 3 315 ? 179.255 176.065 193.021 1.00 71.85  ? 359 THR C C   1 
ATOM   3806 O O   . THR C 3 315 ? 179.070 175.661 194.174 1.00 71.85  ? 359 THR C O   1 
ATOM   3807 C CB  . THR C 3 315 ? 179.094 178.526 193.352 1.00 71.85  ? 359 THR C CB  1 
ATOM   3808 O OG1 . THR C 3 315 ? 178.911 178.356 194.762 1.00 71.85  ? 359 THR C OG1 1 
ATOM   3809 C CG2 . THR C 3 315 ? 177.737 178.524 192.668 1.00 71.85  ? 359 THR C CG2 1 
ATOM   3810 N N   . ALA C 3 316 ? 178.844 175.391 191.946 1.00 69.83  ? 360 ALA C N   1 
ATOM   3811 C CA  . ALA C 3 316 ? 178.177 174.090 192.000 1.00 69.83  ? 360 ALA C CA  1 
ATOM   3812 C C   . ALA C 3 316 ? 176.868 174.132 192.782 1.00 69.83  ? 360 ALA C C   1 
ATOM   3813 O O   . ALA C 3 316 ? 176.454 173.121 193.358 1.00 69.83  ? 360 ALA C O   1 
ATOM   3814 C CB  . ALA C 3 316 ? 179.101 173.012 192.580 1.00 69.83  ? 360 ALA C CB  1 
ATOM   3815 N N   . LEU C 3 317 ? 176.203 175.284 192.816 1.00 68.05  ? 361 LEU C N   1 
ATOM   3816 C CA  . LEU C 3 317 ? 174.912 175.434 193.477 1.00 68.05  ? 361 LEU C CA  1 
ATOM   3817 C C   . LEU C 3 317 ? 173.965 176.162 192.535 1.00 68.05  ? 361 LEU C C   1 
ATOM   3818 O O   . LEU C 3 317 ? 174.270 177.268 192.077 1.00 68.05  ? 361 LEU C O   1 
ATOM   3819 C CB  . LEU C 3 317 ? 175.052 176.195 194.798 1.00 68.05  ? 361 LEU C CB  1 
ATOM   3820 C CG  . LEU C 3 317 ? 175.500 175.371 196.007 1.00 68.05  ? 361 LEU C CG  1 
ATOM   3821 C CD1 . LEU C 3 317 ? 175.596 176.241 197.251 1.00 68.05  ? 361 LEU C CD1 1 
ATOM   3822 C CD2 . LEU C 3 317 ? 174.554 174.205 196.239 1.00 68.05  ? 361 LEU C CD2 1 
ATOM   3823 N N   . VAL C 3 318 ? 172.820 175.542 192.246 1.00 72.35  ? 362 VAL C N   1 
ATOM   3824 C CA  . VAL C 3 318 ? 171.821 176.098 191.342 1.00 72.35  ? 362 VAL C CA  1 
ATOM   3825 C C   . VAL C 3 318 ? 170.447 175.958 191.985 1.00 72.35  ? 362 VAL C C   1 
ATOM   3826 O O   . VAL C 3 318 ? 170.279 175.305 193.016 1.00 72.35  ? 362 VAL C O   1 
ATOM   3827 C CB  . VAL C 3 318 ? 171.832 175.418 189.957 1.00 72.35  ? 362 VAL C CB  1 
ATOM   3828 C CG1 . VAL C 3 318 ? 173.198 175.553 189.301 1.00 72.35  ? 362 VAL C CG1 1 
ATOM   3829 C CG2 . VAL C 3 318 ? 171.435 173.959 190.086 1.00 72.35  ? 362 VAL C CG2 1 
ATOM   3830 N N   . GLY C 3 319 ? 169.456 176.577 191.351 1.00 71.66  ? 363 GLY C N   1 
ATOM   3831 C CA  . GLY C 3 319 ? 168.114 176.613 191.880 1.00 71.66  ? 363 GLY C CA  1 
ATOM   3832 C C   . GLY C 3 319 ? 167.851 177.920 192.596 1.00 71.66  ? 363 GLY C C   1 
ATOM   3833 O O   . GLY C 3 319 ? 168.369 178.974 192.214 1.00 71.66  ? 363 GLY C O   1 
ATOM   3834 N N   . PRO C 3 320 ? 167.040 177.883 193.654 1.00 71.46  ? 364 PRO C N   1 
ATOM   3835 C CA  . PRO C 3 320 ? 166.839 179.096 194.455 1.00 71.46  ? 364 PRO C CA  1 
ATOM   3836 C C   . PRO C 3 320 ? 167.942 179.288 195.484 1.00 71.46  ? 364 PRO C C   1 
ATOM   3837 O O   . PRO C 3 320 ? 167.676 179.636 196.639 1.00 71.46  ? 364 PRO C O   1 
ATOM   3838 C CB  . PRO C 3 320 ? 165.483 178.847 195.122 1.00 71.46  ? 364 PRO C CB  1 
ATOM   3839 C CG  . PRO C 3 320 ? 165.424 177.363 195.268 1.00 71.46  ? 364 PRO C CG  1 
ATOM   3840 C CD  . PRO C 3 320 ? 166.166 176.779 194.089 1.00 71.46  ? 364 PRO C CD  1 
ATOM   3841 N N   . ARG C 3 321 ? 169.192 179.062 195.066 1.00 68.24  ? 365 ARG C N   1 
ATOM   3842 C CA  . ARG C 3 321 ? 170.347 179.317 195.918 1.00 68.24  ? 365 ARG C CA  1 
ATOM   3843 C C   . ARG C 3 321 ? 171.526 179.868 195.123 1.00 68.24  ? 365 ARG C C   1 
ATOM   3844 O O   . ARG C 3 321 ? 172.660 179.843 195.617 1.00 68.24  ? 365 ARG C O   1 
ATOM   3845 C CB  . ARG C 3 321 ? 170.770 178.049 196.663 1.00 68.24  ? 365 ARG C CB  1 
ATOM   3846 C CG  . ARG C 3 321 ? 170.857 176.816 195.786 1.00 68.24  ? 365 ARG C CG  1 
ATOM   3847 C CD  . ARG C 3 321 ? 171.114 175.570 196.615 1.00 68.24  ? 365 ARG C CD  1 
ATOM   3848 N NE  . ARG C 3 321 ? 170.234 175.499 197.778 1.00 68.24  ? 365 ARG C NE  1 
ATOM   3849 C CZ  . ARG C 3 321 ? 169.006 174.992 197.757 1.00 68.24  ? 365 ARG C CZ  1 
ATOM   3850 N NH1 . ARG C 3 321 ? 168.506 174.507 196.629 1.00 68.24  ? 365 ARG C NH1 1 
ATOM   3851 N NH2 . ARG C 3 321 ? 168.278 174.969 198.864 1.00 68.24  ? 365 ARG C NH2 1 
ATOM   3852 N N   . ALA C 3 322 ? 171.292 180.355 193.908 1.00 70.84  ? 366 ALA C N   1 
ATOM   3853 C CA  . ALA C 3 322 ? 172.378 180.844 193.073 1.00 70.84  ? 366 ALA C CA  1 
ATOM   3854 C C   . ALA C 3 322 ? 172.939 182.151 193.622 1.00 70.84  ? 366 ALA C C   1 
ATOM   3855 O O   . ALA C 3 322 ? 172.278 182.873 194.372 1.00 70.84  ? 366 ALA C O   1 
ATOM   3856 C CB  . ALA C 3 322 ? 171.898 181.043 191.636 1.00 70.84  ? 366 ALA C CB  1 
ATOM   3857 N N   . THR C 3 323 ? 174.178 182.448 193.236 1.00 69.79  ? 367 THR C N   1 
ATOM   3858 C CA  . THR C 3 323 ? 174.866 183.643 193.710 1.00 69.79  ? 367 THR C CA  1 
ATOM   3859 C C   . THR C 3 323 ? 174.210 184.881 193.112 1.00 69.79  ? 367 THR C C   1 
ATOM   3860 O O   . THR C 3 323 ? 174.236 185.080 191.894 1.00 69.79  ? 367 THR C O   1 
ATOM   3861 C CB  . THR C 3 323 ? 176.345 183.582 193.341 1.00 69.79  ? 367 THR C CB  1 
ATOM   3862 O OG1 . THR C 3 323 ? 176.842 182.259 193.577 1.00 69.79  ? 367 THR C OG1 1 
ATOM   3863 C CG2 . THR C 3 323 ? 177.141 184.568 194.179 1.00 69.79  ? 367 THR C CG2 1 
ATOM   3864 N N   . SER C 3 324 ? 173.621 185.715 193.966 1.00 72.96  ? 368 SER C N   1 
ATOM   3865 C CA  . SER C 3 324 ? 172.992 186.948 193.514 1.00 72.96  ? 368 SER C CA  1 
ATOM   3866 C C   . SER C 3 324 ? 174.026 188.063 193.442 1.00 72.96  ? 368 SER C C   1 
ATOM   3867 O O   . SER C 3 324 ? 174.777 188.289 194.396 1.00 72.96  ? 368 SER C O   1 
ATOM   3868 C CB  . SER C 3 324 ? 171.851 187.340 194.451 1.00 72.96  ? 368 SER C CB  1 
ATOM   3869 O OG  . SER C 3 324 ? 170.795 186.397 194.390 1.00 72.96  ? 368 SER C OG  1 
ATOM   3870 N N   . TYR C 3 325 ? 174.062 188.761 192.311 1.00 71.62  ? 369 TYR C N   1 
ATOM   3871 C CA  . TYR C 3 325 ? 175.025 189.824 192.069 1.00 71.62  ? 369 TYR C CA  1 
ATOM   3872 C C   . TYR C 3 325 ? 174.351 191.181 192.214 1.00 71.62  ? 369 TYR C C   1 
ATOM   3873 O O   . TYR C 3 325 ? 173.198 191.358 191.809 1.00 71.62  ? 369 TYR C O   1 
ATOM   3874 C CB  . TYR C 3 325 ? 175.647 189.694 190.677 1.00 71.62  ? 369 TYR C CB  1 
ATOM   3875 C CG  . TYR C 3 325 ? 176.522 188.473 190.513 1.00 71.62  ? 369 TYR C CG  1 
ATOM   3876 C CD1 . TYR C 3 325 ? 177.877 188.521 190.808 1.00 71.62  ? 369 TYR C CD1 1 
ATOM   3877 C CD2 . TYR C 3 325 ? 175.992 187.272 190.062 1.00 71.62  ? 369 TYR C CD2 1 
ATOM   3878 C CE1 . TYR C 3 325 ? 178.680 187.409 190.659 1.00 71.62  ? 369 TYR C CE1 1 
ATOM   3879 C CE2 . TYR C 3 325 ? 176.788 186.154 189.910 1.00 71.62  ? 369 TYR C CE2 1 
ATOM   3880 C CZ  . TYR C 3 325 ? 178.130 186.228 190.210 1.00 71.62  ? 369 TYR C CZ  1 
ATOM   3881 O OH  . TYR C 3 325 ? 178.926 185.117 190.060 1.00 71.62  ? 369 TYR C OH  1 
ATOM   3882 N N   . THR C 3 326 ? 175.076 192.135 192.793 1.00 76.29  ? 370 THR C N   1 
ATOM   3883 C CA  . THR C 3 326 ? 174.555 193.477 193.029 1.00 76.29  ? 370 THR C CA  1 
ATOM   3884 C C   . THR C 3 326 ? 175.688 194.478 192.877 1.00 76.29  ? 370 THR C C   1 
ATOM   3885 O O   . THR C 3 326 ? 176.660 194.438 193.637 1.00 76.29  ? 370 THR C O   1 
ATOM   3886 C CB  . THR C 3 326 ? 173.925 193.590 194.421 1.00 76.29  ? 370 THR C CB  1 
ATOM   3887 O OG1 . THR C 3 326 ? 172.833 192.669 194.531 1.00 76.29  ? 370 THR C OG1 1 
ATOM   3888 C CG2 . THR C 3 326 ? 173.415 195.001 194.660 1.00 76.29  ? 370 THR C CG2 1 
ATOM   3889 N N   . LEU C 3 327 ? 175.563 195.370 191.900 1.00 78.94  ? 371 LEU C N   1 
ATOM   3890 C CA  . LEU C 3 327 ? 176.536 196.428 191.665 1.00 78.94  ? 371 LEU C CA  1 
ATOM   3891 C C   . LEU C 3 327 ? 176.032 197.719 192.295 1.00 78.94  ? 371 LEU C C   1 
ATOM   3892 O O   . LEU C 3 327 ? 174.879 198.106 192.084 1.00 78.94  ? 371 LEU C O   1 
ATOM   3893 C CB  . LEU C 3 327 ? 176.774 196.620 190.165 1.00 78.94  ? 371 LEU C CB  1 
ATOM   3894 C CG  . LEU C 3 327 ? 177.804 197.661 189.723 1.00 78.94  ? 371 LEU C CG  1 
ATOM   3895 C CD1 . LEU C 3 327 ? 178.587 197.147 188.529 1.00 78.94  ? 371 LEU C CD1 1 
ATOM   3896 C CD2 . LEU C 3 327 ? 177.124 198.975 189.377 1.00 78.94  ? 371 LEU C CD2 1 
ATOM   3897 N N   . VAL C 3 328 ? 176.895 198.381 193.063 1.00 81.68  ? 372 VAL C N   1 
ATOM   3898 C CA  . VAL C 3 328 ? 176.523 199.590 193.785 1.00 81.68  ? 372 VAL C CA  1 
ATOM   3899 C C   . VAL C 3 328 ? 177.525 200.693 193.475 1.00 81.68  ? 372 VAL C C   1 
ATOM   3900 O O   . VAL C 3 328 ? 178.706 200.438 193.223 1.00 81.68  ? 372 VAL C O   1 
ATOM   3901 C CB  . VAL C 3 328 ? 176.428 199.336 195.309 1.00 81.68  ? 372 VAL C CB  1 
ATOM   3902 C CG1 . VAL C 3 328 ? 177.808 199.131 195.911 1.00 81.68  ? 372 VAL C CG1 1 
ATOM   3903 C CG2 . VAL C 3 328 ? 175.695 200.474 196.004 1.00 81.68  ? 372 VAL C CG2 1 
ATOM   3904 N N   . GLU C 3 329 ? 177.034 201.930 193.478 1.00 90.46  ? 373 GLU C N   1 
ATOM   3905 C CA  . GLU C 3 329 ? 177.849 203.113 193.239 1.00 90.46  ? 373 GLU C CA  1 
ATOM   3906 C C   . GLU C 3 329 ? 178.210 203.763 194.569 1.00 90.46  ? 373 GLU C C   1 
ATOM   3907 O O   . GLU C 3 329 ? 177.412 203.759 195.510 1.00 90.46  ? 373 GLU C O   1 
ATOM   3908 C CB  . GLU C 3 329 ? 177.104 204.108 192.343 1.00 90.46  ? 373 GLU C CB  1 
ATOM   3909 C CG  . GLU C 3 329 ? 177.739 205.488 192.238 1.00 90.46  ? 373 GLU C CG  1 
ATOM   3910 C CD  . GLU C 3 329 ? 179.062 205.473 191.500 1.00 90.46  ? 373 GLU C CD  1 
ATOM   3911 O OE1 . GLU C 3 329 ? 179.294 204.536 190.709 1.00 90.46  ? 373 GLU C OE1 1 
ATOM   3912 O OE2 . GLU C 3 329 ? 179.871 206.401 191.709 1.00 90.46  ? 373 GLU C OE2 1 
ATOM   3913 N N   . SER C 3 330 ? 179.421 204.318 194.643 1.00 89.28  ? 374 SER C N   1 
ATOM   3914 C CA  . SER C 3 330 ? 179.893 204.904 195.892 1.00 89.28  ? 374 SER C CA  1 
ATOM   3915 C C   . SER C 3 330 ? 179.469 206.362 196.029 1.00 89.28  ? 374 SER C C   1 
ATOM   3916 O O   . SER C 3 330 ? 178.964 206.772 197.080 1.00 89.28  ? 374 SER C O   1 
ATOM   3917 C CB  . SER C 3 330 ? 181.414 204.782 195.982 1.00 89.28  ? 374 SER C CB  1 
ATOM   3918 O OG  . SER C 3 330 ? 182.025 205.105 194.745 1.00 89.28  ? 374 SER C OG  1 
ATOM   3919 N N   . PHE C 3 331 ? 179.674 207.161 194.980 1.00 92.58  ? 375 PHE C N   1 
ATOM   3920 C CA  . PHE C 3 331 ? 179.410 208.594 195.076 1.00 92.58  ? 375 PHE C CA  1 
ATOM   3921 C C   . PHE C 3 331 ? 177.921 208.885 195.222 1.00 92.58  ? 375 PHE C C   1 
ATOM   3922 O O   . PHE C 3 331 ? 177.537 209.878 195.850 1.00 92.58  ? 375 PHE C O   1 
ATOM   3923 C CB  . PHE C 3 331 ? 179.975 209.316 193.853 1.00 92.58  ? 375 PHE C CB  1 
ATOM   3924 C CG  . PHE C 3 331 ? 181.471 209.449 193.864 1.00 92.58  ? 375 PHE C CG  1 
ATOM   3925 C CD1 . PHE C 3 331 ? 182.179 209.365 195.050 1.00 92.58  ? 375 PHE C CD1 1 
ATOM   3926 C CD2 . PHE C 3 331 ? 182.168 209.659 192.686 1.00 92.58  ? 375 PHE C CD2 1 
ATOM   3927 C CE1 . PHE C 3 331 ? 183.555 209.487 195.061 1.00 92.58  ? 375 PHE C CE1 1 
ATOM   3928 C CE2 . PHE C 3 331 ? 183.544 209.783 192.691 1.00 92.58  ? 375 PHE C CE2 1 
ATOM   3929 C CZ  . PHE C 3 331 ? 184.238 209.697 193.880 1.00 92.58  ? 375 PHE C CZ  1 
ATOM   3930 N N   . SER C 3 332 ? 177.067 208.035 194.652 1.00 90.73  ? 376 SER C N   1 
ATOM   3931 C CA  . SER C 3 332 ? 175.632 208.275 194.654 1.00 90.73  ? 376 SER C CA  1 
ATOM   3932 C C   . SER C 3 332 ? 174.839 207.247 195.447 1.00 90.73  ? 376 SER C C   1 
ATOM   3933 O O   . SER C 3 332 ? 173.652 207.474 195.705 1.00 90.73  ? 376 SER C O   1 
ATOM   3934 C CB  . SER C 3 332 ? 175.104 208.315 193.213 1.00 90.73  ? 376 SER C CB  1 
ATOM   3935 O OG  . SER C 3 332 ? 175.959 209.083 192.387 1.00 90.73  ? 376 SER C OG  1 
ATOM   3936 N N   . GLY C 3 333 ? 175.451 206.132 195.839 1.00 92.96  ? 377 GLY C N   1 
ATOM   3937 C CA  . GLY C 3 333 ? 174.749 205.130 196.615 1.00 92.96  ? 377 GLY C CA  1 
ATOM   3938 C C   . GLY C 3 333 ? 173.704 204.341 195.862 1.00 92.96  ? 377 GLY C C   1 
ATOM   3939 O O   . GLY C 3 333 ? 172.974 203.562 196.482 1.00 92.96  ? 377 GLY C O   1 
ATOM   3940 N N   . LYS C 3 334 ? 173.604 204.514 194.547 1.00 87.12  ? 378 LYS C N   1 
ATOM   3941 C CA  . LYS C 3 334 ? 172.627 203.776 193.760 1.00 87.12  ? 378 LYS C CA  1 
ATOM   3942 C C   . LYS C 3 334 ? 173.150 202.382 193.444 1.00 87.12  ? 378 LYS C C   1 
ATOM   3943 O O   . LYS C 3 334 ? 174.352 202.183 193.247 1.00 87.12  ? 378 LYS C O   1 
ATOM   3944 C CB  . LYS C 3 334 ? 172.306 204.526 192.468 1.00 87.12  ? 378 LYS C CB  1 
ATOM   3945 C CG  . LYS C 3 334 ? 171.976 205.995 192.676 1.00 87.12  ? 378 LYS C CG  1 
ATOM   3946 C CD  . LYS C 3 334 ? 170.842 206.170 193.672 1.00 87.12  ? 378 LYS C CD  1 
ATOM   3947 C CE  . LYS C 3 334 ? 170.587 207.639 193.965 1.00 87.12  ? 378 LYS C CE  1 
ATOM   3948 N NZ  . LYS C 3 334 ? 170.286 208.409 192.727 1.00 87.12  ? 378 LYS C NZ  1 
ATOM   3949 N N   . TYR C 3 335 ? 172.238 201.413 193.396 1.00 86.27  ? 379 TYR C N   1 
ATOM   3950 C CA  . TYR C 3 335 ? 172.605 200.023 193.177 1.00 86.27  ? 379 TYR C CA  1 
ATOM   3951 C C   . TYR C 3 335 ? 171.640 199.385 192.190 1.00 86.27  ? 379 TYR C C   1 
ATOM   3952 O O   . TYR C 3 335 ? 170.495 199.816 192.037 1.00 86.27  ? 379 TYR C O   1 
ATOM   3953 C CB  . TYR C 3 335 ? 172.618 199.228 194.491 1.00 86.27  ? 379 TYR C CB  1 
ATOM   3954 C CG  . TYR C 3 335 ? 171.280 199.176 195.194 1.00 86.27  ? 379 TYR C CG  1 
ATOM   3955 C CD1 . TYR C 3 335 ? 170.876 200.202 196.037 1.00 86.27  ? 379 TYR C CD1 1 
ATOM   3956 C CD2 . TYR C 3 335 ? 170.423 198.097 195.019 1.00 86.27  ? 379 TYR C CD2 1 
ATOM   3957 C CE1 . TYR C 3 335 ? 169.655 200.159 196.681 1.00 86.27  ? 379 TYR C CE1 1 
ATOM   3958 C CE2 . TYR C 3 335 ? 169.201 198.045 195.659 1.00 86.27  ? 379 TYR C CE2 1 
ATOM   3959 C CZ  . TYR C 3 335 ? 168.822 199.078 196.488 1.00 86.27  ? 379 TYR C CZ  1 
ATOM   3960 O OH  . TYR C 3 335 ? 167.606 199.030 197.129 1.00 86.27  ? 379 TYR C OH  1 
ATOM   3961 N N   . VAL C 3 336 ? 172.124 198.343 191.516 1.00 85.05  ? 380 VAL C N   1 
ATOM   3962 C CA  . VAL C 3 336 ? 171.336 197.563 190.570 1.00 85.05  ? 380 VAL C CA  1 
ATOM   3963 C C   . VAL C 3 336 ? 171.461 196.095 190.948 1.00 85.05  ? 380 VAL C C   1 
ATOM   3964 O O   . VAL C 3 336 ? 172.563 195.619 191.242 1.00 85.05  ? 380 VAL C O   1 
ATOM   3965 C CB  . VAL C 3 336 ? 171.792 197.785 189.115 1.00 85.05  ? 380 VAL C CB  1 
ATOM   3966 C CG1 . VAL C 3 336 ? 170.778 197.199 188.148 1.00 85.05  ? 380 VAL C CG1 1 
ATOM   3967 C CG2 . VAL C 3 336 ? 172.004 199.265 188.838 1.00 85.05  ? 380 VAL C CG2 1 
ATOM   3968 N N   . ARG C 3 337 ? 170.338 195.381 190.942 1.00 88.27  ? 381 ARG C N   1 
ATOM   3969 C CA  . ARG C 3 337 ? 170.295 193.974 191.320 1.00 88.27  ? 381 ARG C CA  1 
ATOM   3970 C C   . ARG C 3 337 ? 169.841 193.138 190.132 1.00 88.27  ? 381 ARG C C   1 
ATOM   3971 O O   . ARG C 3 337 ? 168.871 193.490 189.453 1.00 88.27  ? 381 ARG C O   1 
ATOM   3972 C CB  . ARG C 3 337 ? 169.362 193.753 192.513 1.00 88.27  ? 381 ARG C CB  1 
ATOM   3973 C CG  . ARG C 3 337 ? 168.877 192.321 192.659 1.00 88.27  ? 381 ARG C CG  1 
ATOM   3974 C CD  . ARG C 3 337 ? 168.738 191.926 194.117 1.00 88.27  ? 381 ARG C CD  1 
ATOM   3975 N NE  . ARG C 3 337 ? 168.407 190.513 194.265 1.00 88.27  ? 381 ARG C NE  1 
ATOM   3976 C CZ  . ARG C 3 337 ? 168.476 189.845 195.411 1.00 88.27  ? 381 ARG C CZ  1 
ATOM   3977 N NH1 . ARG C 3 337 ? 168.866 190.463 196.518 1.00 88.27  ? 381 ARG C NH1 1 
ATOM   3978 N NH2 . ARG C 3 337 ? 168.157 188.559 195.453 1.00 88.27  ? 381 ARG C NH2 1 
ATOM   3979 N N   . LEU C 3 338 ? 170.541 192.033 189.888 1.00 92.13  ? 382 LEU C N   1 
ATOM   3980 C CA  . LEU C 3 338 ? 170.206 191.140 188.789 1.00 92.13  ? 382 LEU C CA  1 
ATOM   3981 C C   . LEU C 3 338 ? 169.106 190.167 189.200 1.00 92.13  ? 382 LEU C C   1 
ATOM   3982 O O   . LEU C 3 338 ? 169.103 189.629 190.310 1.00 92.13  ? 382 LEU C O   1 
ATOM   3983 C CB  . LEU C 3 338 ? 171.445 190.368 188.332 1.00 92.13  ? 382 LEU C CB  1 
ATOM   3984 C CG  . LEU C 3 338 ? 171.275 189.417 187.146 1.00 92.13  ? 382 LEU C CG  1 
ATOM   3985 C CD1 . LEU C 3 338 ? 170.757 190.167 185.931 1.00 92.13  ? 382 LEU C CD1 1 
ATOM   3986 C CD2 . LEU C 3 338 ? 172.589 188.724 186.828 1.00 92.13  ? 382 LEU C CD2 1 
ATOM   3987 N N   . LYS C 3 339 ? 168.167 189.944 188.285 1.00 108.16 ? 383 LYS C N   1 
ATOM   3988 C CA  . LYS C 3 339 ? 167.028 189.073 188.530 1.00 108.16 ? 383 LYS C CA  1 
ATOM   3989 C C   . LYS C 3 339 ? 167.440 187.622 188.259 1.00 108.16 ? 383 LYS C C   1 
ATOM   3990 O O   . LYS C 3 339 ? 168.592 187.335 187.926 1.00 108.16 ? 383 LYS C O   1 
ATOM   3991 C CB  . LYS C 3 339 ? 165.840 189.549 187.686 1.00 108.16 ? 383 LYS C CB  1 
ATOM   3992 C CG  . LYS C 3 339 ? 164.488 188.872 187.946 1.00 108.16 ? 383 LYS C CG  1 
ATOM   3993 C CD  . LYS C 3 339 ? 164.033 188.930 189.408 1.00 108.16 ? 383 LYS C CD  1 
ATOM   3994 C CE  . LYS C 3 339 ? 164.164 190.321 190.017 1.00 108.16 ? 383 LYS C CE  1 
ATOM   3995 N NZ  . LYS C 3 339 ? 163.550 190.385 191.373 1.00 108.16 ? 383 LYS C NZ  1 
ATOM   3996 N N   . ARG C 3 340 ? 166.495 186.685 188.403 1.00 109.35 ? 384 ARG C N   1 
ATOM   3997 C CA  . ARG C 3 340 ? 166.800 185.264 188.264 1.00 109.35 ? 384 ARG C CA  1 
ATOM   3998 C C   . ARG C 3 340 ? 167.239 184.903 186.848 1.00 109.35 ? 384 ARG C C   1 
ATOM   3999 O O   . ARG C 3 340 ? 167.860 183.853 186.647 1.00 109.35 ? 384 ARG C O   1 
ATOM   4000 C CB  . ARG C 3 340 ? 165.586 184.430 188.675 1.00 109.35 ? 384 ARG C CB  1 
ATOM   4001 C CG  . ARG C 3 340 ? 165.852 182.938 188.811 1.00 109.35 ? 384 ARG C CG  1 
ATOM   4002 C CD  . ARG C 3 340 ? 167.006 182.654 189.761 1.00 109.35 ? 384 ARG C CD  1 
ATOM   4003 N NE  . ARG C 3 340 ? 166.759 183.168 191.107 1.00 109.35 ? 384 ARG C NE  1 
ATOM   4004 C CZ  . ARG C 3 340 ? 167.598 183.020 192.127 1.00 109.35 ? 384 ARG C CZ  1 
ATOM   4005 N NH1 . ARG C 3 340 ? 168.740 182.369 191.956 1.00 109.35 ? 384 ARG C NH1 1 
ATOM   4006 N NH2 . ARG C 3 340 ? 167.297 183.519 193.320 1.00 109.35 ? 384 ARG C NH2 1 
ATOM   4007 N N   . ALA C 3 341 ? 166.926 185.739 185.859 1.00 119.83 ? 385 ALA C N   1 
ATOM   4008 C CA  . ALA C 3 341 ? 167.393 185.491 184.500 1.00 119.83 ? 385 ALA C CA  1 
ATOM   4009 C C   . ALA C 3 341 ? 168.917 185.456 184.470 1.00 119.83 ? 385 ALA C C   1 
ATOM   4010 O O   . ALA C 3 341 ? 169.576 186.476 184.695 1.00 119.83 ? 385 ALA C O   1 
ATOM   4011 C CB  . ALA C 3 341 ? 166.861 186.566 183.553 1.00 119.83 ? 385 ALA C CB  1 
ATOM   4012 N N   . GLU C 3 342 ? 169.501 184.273 184.268 1.00 122.99 ? 386 GLU C N   1 
ATOM   4013 C CA  . GLU C 3 342 ? 170.985 184.186 184.341 1.00 122.99 ? 386 GLU C CA  1 
ATOM   4014 C C   . GLU C 3 342 ? 171.549 183.722 182.988 1.00 122.99 ? 386 GLU C C   1 
ATOM   4015 O O   . GLU C 3 342 ? 171.083 182.680 182.480 1.00 122.99 ? 386 GLU C O   1 
ATOM   4016 C CB  . GLU C 3 342 ? 171.425 183.285 185.496 1.00 122.99 ? 386 GLU C CB  1 
ATOM   4017 C CG  . GLU C 3 342 ? 171.194 183.924 186.863 1.00 122.99 ? 386 GLU C CG  1 
ATOM   4018 C CD  . GLU C 3 342 ? 171.928 183.263 188.014 1.00 122.99 ? 386 GLU C CD  1 
ATOM   4019 O OE1 . GLU C 3 342 ? 171.775 183.738 189.159 1.00 122.99 ? 386 GLU C OE1 1 
ATOM   4020 O OE2 . GLU C 3 342 ? 172.657 182.279 187.767 1.00 122.99 ? 386 GLU C OE2 1 
ATOM   4021 N N   . ALA C 3 343 ? 172.476 184.499 182.422 1.00 131.14 ? 387 ALA C N   1 
ATOM   4022 C CA  . ALA C 3 343 ? 173.055 184.168 181.099 1.00 131.14 ? 387 ALA C CA  1 
ATOM   4023 C C   . ALA C 3 343 ? 174.216 183.190 181.278 1.00 131.14 ? 387 ALA C C   1 
ATOM   4024 O O   . ALA C 3 343 ? 174.868 183.210 182.345 1.00 131.14 ? 387 ALA C O   1 
ATOM   4025 C CB  . ALA C 3 343 ? 173.505 185.440 180.418 1.00 131.14 ? 387 ALA C CB  1 
ATOM   4026 N N   . PRO C 3 344 ? 174.515 182.332 180.279 1.00 140.50 ? 388 PRO C N   1 
ATOM   4027 C CA  . PRO C 3 344 ? 175.655 181.433 180.373 1.00 140.50 ? 388 PRO C CA  1 
ATOM   4028 C C   . PRO C 3 344 ? 176.959 182.216 180.419 1.00 140.50 ? 388 PRO C C   1 
ATOM   4029 O O   . PRO C 3 344 ? 177.011 183.352 179.908 1.00 140.50 ? 388 PRO C O   1 
ATOM   4030 C CB  . PRO C 3 344 ? 175.534 180.576 179.104 1.00 140.50 ? 388 PRO C CB  1 
ATOM   4031 C CG  . PRO C 3 344 ? 174.742 181.442 178.151 1.00 140.50 ? 388 PRO C CG  1 
ATOM   4032 C CD  . PRO C 3 344 ? 173.766 182.191 179.041 1.00 140.50 ? 388 PRO C CD  1 
ATOM   4033 N N   . THR C 3 345 ? 177.998 181.620 181.010 1.00 30.00  ? 389 THR C N   1 
ATOM   4034 C CA  . THR C 3 345 ? 179.318 182.284 181.080 1.00 30.00  ? 389 THR C CA  1 
ATOM   4035 C C   . THR C 3 345 ? 179.795 182.570 179.673 1.00 30.00  ? 389 THR C C   1 
ATOM   4036 O O   . THR C 3 345 ? 180.569 183.535 179.499 1.00 30.00  ? 389 THR C O   1 
ATOM   4037 C CB  . THR C 3 345 ? 180.301 181.393 181.836 1.00 30.00  ? 389 THR C CB  1 
ATOM   4038 O OG1 . THR C 3 345 ? 180.438 180.229 181.027 1.00 30.00  ? 389 THR C OG1 1 
ATOM   4039 C CG2 . THR C 3 345 ? 179.798 181.015 183.217 1.00 30.00  ? 389 THR C CG2 1 
ATOM   4040 N N   . ASN C 3 346 ? 179.348 181.771 178.698 1.00 143.93 ? 390 ASN C N   1 
ATOM   4041 C CA  . ASN C 3 346 ? 179.722 182.002 177.275 1.00 143.93 ? 390 ASN C CA  1 
ATOM   4042 C C   . ASN C 3 346 ? 179.586 183.498 176.978 1.00 143.93 ? 390 ASN C C   1 
ATOM   4043 O O   . ASN C 3 346 ? 180.530 184.071 176.392 1.00 143.93 ? 390 ASN C O   1 
ATOM   4044 C CB  . ASN C 3 346 ? 178.891 181.131 176.338 1.00 143.93 ? 390 ASN C CB  1 
ATOM   4045 C CG  . ASN C 3 346 ? 177.455 181.017 176.790 1.00 143.93 ? 390 ASN C CG  1 
ATOM   4046 O OD1 . ASN C 3 346 ? 176.745 182.025 176.876 1.00 143.93 ? 390 ASN C OD1 1 
ATOM   4047 N ND2 . ASN C 3 346 ? 177.009 179.804 177.083 1.00 143.93 ? 390 ASN C ND2 1 
ATOM   4048 N N   . GLU C 3 347 ? 178.463 184.106 177.368 1.00 137.09 ? 391 GLU C N   1 
ATOM   4049 C CA  . GLU C 3 347 ? 178.305 185.575 177.205 1.00 137.09 ? 391 GLU C CA  1 
ATOM   4050 C C   . GLU C 3 347 ? 178.706 186.245 178.529 1.00 137.09 ? 391 GLU C C   1 
ATOM   4051 O O   . GLU C 3 347 ? 177.834 186.378 179.416 1.00 137.09 ? 391 GLU C O   1 
ATOM   4052 C CB  . GLU C 3 347 ? 176.879 185.916 176.769 1.00 137.09 ? 391 GLU C CB  1 
ATOM   4053 C CG  . GLU C 3 347 ? 175.812 185.067 177.453 1.00 137.09 ? 391 GLU C CG  1 
ATOM   4054 C CD  . GLU C 3 347 ? 174.399 185.361 176.986 1.00 137.09 ? 391 GLU C CD  1 
ATOM   4055 O OE1 . GLU C 3 347 ? 173.741 184.435 176.467 1.00 137.09 ? 391 GLU C OE1 1 
ATOM   4056 O OE2 . GLU C 3 347 ? 173.957 186.519 177.140 1.00 137.09 ? 391 GLU C OE2 1 
ATOM   4057 N N   . SER C 3 348 ? 179.979 186.632 178.662 1.00 117.17 ? 392 SER C N   1 
ATOM   4058 C CA  . SER C 3 348 ? 180.453 187.227 179.915 1.00 117.17 ? 392 SER C CA  1 
ATOM   4059 C C   . SER C 3 348 ? 179.450 188.214 180.506 1.00 117.17 ? 392 SER C C   1 
ATOM   4060 O O   . SER C 3 348 ? 178.936 189.091 179.806 1.00 117.17 ? 392 SER C O   1 
ATOM   4061 C CB  . SER C 3 348 ? 181.795 187.923 179.675 1.00 117.17 ? 392 SER C CB  1 
ATOM   4062 O OG  . SER C 3 348 ? 182.862 186.990 179.694 1.00 117.17 ? 392 SER C OG  1 
ATOM   4063 N N   . TYR C 3 349 ? 179.169 188.044 181.802 1.00 101.81 ? 393 TYR C N   1 
ATOM   4064 C CA  . TYR C 3 349 ? 178.054 188.721 182.460 1.00 101.81 ? 393 TYR C CA  1 
ATOM   4065 C C   . TYR C 3 349 ? 178.114 190.229 182.270 1.00 101.81 ? 393 TYR C C   1 
ATOM   4066 O O   . TYR C 3 349 ? 179.193 190.824 182.226 1.00 101.81 ? 393 TYR C O   1 
ATOM   4067 C CB  . TYR C 3 349 ? 178.054 188.400 183.956 1.00 101.81 ? 393 TYR C CB  1 
ATOM   4068 C CG  . TYR C 3 349 ? 177.277 187.162 184.340 1.00 101.81 ? 393 TYR C CG  1 
ATOM   4069 C CD1 . TYR C 3 349 ? 175.889 187.168 184.360 1.00 101.81 ? 393 TYR C CD1 1 
ATOM   4070 C CD2 . TYR C 3 349 ? 177.932 185.995 184.706 1.00 101.81 ? 393 TYR C CD2 1 
ATOM   4071 C CE1 . TYR C 3 349 ? 175.175 186.040 184.719 1.00 101.81 ? 393 TYR C CE1 1 
ATOM   4072 C CE2 . TYR C 3 349 ? 177.227 184.864 185.067 1.00 101.81 ? 393 TYR C CE2 1 
ATOM   4073 C CZ  . TYR C 3 349 ? 175.851 184.894 185.072 1.00 101.81 ? 393 TYR C CZ  1 
ATOM   4074 O OH  . TYR C 3 349 ? 175.148 183.770 185.430 1.00 101.81 ? 393 TYR C OH  1 
ATOM   4075 N N   . GLN C 3 350 ? 176.937 190.847 182.172 1.00 95.59  ? 394 GLN C N   1 
ATOM   4076 C CA  . GLN C 3 350 ? 176.822 192.288 182.003 1.00 95.59  ? 394 GLN C CA  1 
ATOM   4077 C C   . GLN C 3 350 ? 175.613 192.802 182.771 1.00 95.59  ? 394 GLN C C   1 
ATOM   4078 O O   . GLN C 3 350 ? 174.644 192.072 183.000 1.00 95.59  ? 394 GLN C O   1 
ATOM   4079 C CB  . GLN C 3 350 ? 176.696 192.675 180.525 1.00 95.59  ? 394 GLN C CB  1 
ATOM   4080 C CG  . GLN C 3 350 ? 175.433 192.155 179.857 1.00 95.59  ? 394 GLN C CG  1 
ATOM   4081 C CD  . GLN C 3 350 ? 175.130 192.861 178.551 1.00 95.59  ? 394 GLN C CD  1 
ATOM   4082 O OE1 . GLN C 3 350 ? 175.577 193.984 178.321 1.00 95.59  ? 394 GLN C OE1 1 
ATOM   4083 N NE2 . GLN C 3 350 ? 174.366 192.204 177.687 1.00 95.59  ? 394 GLN C NE2 1 
ATOM   4084 N N   . LEU C 3 351 ? 175.682 194.072 183.165 1.00 91.26  ? 395 LEU C N   1 
ATOM   4085 C CA  . LEU C 3 351 ? 174.579 194.746 183.834 1.00 91.26  ? 395 LEU C CA  1 
ATOM   4086 C C   . LEU C 3 351 ? 174.640 196.226 183.490 1.00 91.26  ? 395 LEU C C   1 
ATOM   4087 O O   . LEU C 3 351 ? 175.721 196.820 183.472 1.00 91.26  ? 395 LEU C O   1 
ATOM   4088 C CB  . LEU C 3 351 ? 174.630 194.544 185.353 1.00 91.26  ? 395 LEU C CB  1 
ATOM   4089 C CG  . LEU C 3 351 ? 173.356 194.897 186.123 1.00 91.26  ? 395 LEU C CG  1 
ATOM   4090 C CD1 . LEU C 3 351 ? 172.153 194.197 185.513 1.00 91.26  ? 395 LEU C CD1 1 
ATOM   4091 C CD2 . LEU C 3 351 ? 173.497 194.533 187.592 1.00 91.26  ? 395 LEU C CD2 1 
ATOM   4092 N N   . LEU C 3 352 ? 173.478 196.813 183.216 1.00 92.88  ? 396 LEU C N   1 
ATOM   4093 C CA  . LEU C 3 352 ? 173.398 198.199 182.776 1.00 92.88  ? 396 LEU C CA  1 
ATOM   4094 C C   . LEU C 3 352 ? 173.278 199.143 183.966 1.00 92.88  ? 396 LEU C C   1 
ATOM   4095 O O   . LEU C 3 352 ? 172.667 198.807 184.984 1.00 92.88  ? 396 LEU C O   1 
ATOM   4096 C CB  . LEU C 3 352 ? 172.216 198.389 181.821 1.00 92.88  ? 396 LEU C CB  1 
ATOM   4097 C CG  . LEU C 3 352 ? 170.796 198.066 182.301 1.00 92.88  ? 396 LEU C CG  1 
ATOM   4098 C CD1 . LEU C 3 352 ? 170.124 199.260 182.971 1.00 92.88  ? 396 LEU C CD1 1 
ATOM   4099 C CD2 . LEU C 3 352 ? 169.952 197.549 181.147 1.00 92.88  ? 396 LEU C CD2 1 
ATOM   4100 N N   . PHE C 3 353 ? 173.872 200.327 183.827 1.00 91.98  ? 397 PHE C N   1 
ATOM   4101 C CA  . PHE C 3 353 ? 173.830 201.364 184.852 1.00 91.98  ? 397 PHE C CA  1 
ATOM   4102 C C   . PHE C 3 353 ? 173.607 202.704 184.171 1.00 91.98  ? 397 PHE C C   1 
ATOM   4103 O O   . PHE C 3 353 ? 174.416 203.118 183.334 1.00 91.98  ? 397 PHE C O   1 
ATOM   4104 C CB  . PHE C 3 353 ? 175.123 201.384 185.673 1.00 91.98  ? 397 PHE C CB  1 
ATOM   4105 C CG  . PHE C 3 353 ? 175.079 202.316 186.851 1.00 91.98  ? 397 PHE C CG  1 
ATOM   4106 C CD1 . PHE C 3 353 ? 175.586 203.601 186.754 1.00 91.98  ? 397 PHE C CD1 1 
ATOM   4107 C CD2 . PHE C 3 353 ? 174.534 201.905 188.055 1.00 91.98  ? 397 PHE C CD2 1 
ATOM   4108 C CE1 . PHE C 3 353 ? 175.548 204.458 187.836 1.00 91.98  ? 397 PHE C CE1 1 
ATOM   4109 C CE2 . PHE C 3 353 ? 174.493 202.758 189.141 1.00 91.98  ? 397 PHE C CE2 1 
ATOM   4110 C CZ  . PHE C 3 353 ? 175.001 204.036 189.031 1.00 91.98  ? 397 PHE C CZ  1 
ATOM   4111 N N   . GLN C 3 354 ? 172.515 203.377 184.527 1.00 92.43  ? 398 GLN C N   1 
ATOM   4112 C CA  . GLN C 3 354 ? 172.179 204.650 183.902 1.00 92.43  ? 398 GLN C CA  1 
ATOM   4113 C C   . GLN C 3 354 ? 173.200 205.716 184.281 1.00 92.43  ? 398 GLN C C   1 
ATOM   4114 O O   . GLN C 3 354 ? 173.545 205.872 185.456 1.00 92.43  ? 398 GLN C O   1 
ATOM   4115 C CB  . GLN C 3 354 ? 170.776 205.087 184.317 1.00 92.43  ? 398 GLN C CB  1 
ATOM   4116 C CG  . GLN C 3 354 ? 169.698 204.052 184.042 1.00 92.43  ? 398 GLN C CG  1 
ATOM   4117 C CD  . GLN C 3 354 ? 169.341 203.952 182.572 1.00 92.43  ? 398 GLN C CD  1 
ATOM   4118 O OE1 . GLN C 3 354 ? 169.732 204.796 181.766 1.00 92.43  ? 398 GLN C OE1 1 
ATOM   4119 N NE2 . GLN C 3 354 ? 168.592 202.915 182.215 1.00 92.43  ? 398 GLN C NE2 1 
ATOM   4120 N N   . MET C 3 355 ? 173.683 206.448 183.282 1.00 94.34  ? 399 MET C N   1 
ATOM   4121 C CA  . MET C 3 355 ? 174.669 207.490 183.529 1.00 94.34  ? 399 MET C CA  1 
ATOM   4122 C C   . MET C 3 355 ? 174.038 208.657 184.277 1.00 94.34  ? 399 MET C C   1 
ATOM   4123 O O   . MET C 3 355 ? 172.927 209.091 183.962 1.00 94.34  ? 399 MET C O   1 
ATOM   4124 C CB  . MET C 3 355 ? 175.271 207.975 182.211 1.00 94.34  ? 399 MET C CB  1 
ATOM   4125 C CG  . MET C 3 355 ? 176.408 208.970 182.378 1.00 94.34  ? 399 MET C CG  1 
ATOM   4126 S SD  . MET C 3 355 ? 177.179 209.410 180.810 1.00 94.34  ? 399 MET C SD  1 
ATOM   4127 C CE  . MET C 3 355 ? 178.368 210.637 181.349 1.00 94.34  ? 399 MET C CE  1 
ATOM   4128 N N   . LEU C 3 356 ? 174.757 209.163 185.276 1.00 96.61  ? 400 LEU C N   1 
ATOM   4129 C CA  . LEU C 3 356 ? 174.256 210.269 186.081 1.00 96.61  ? 400 LEU C CA  1 
ATOM   4130 C C   . LEU C 3 356 ? 174.637 211.601 185.437 1.00 96.61  ? 400 LEU C C   1 
ATOM   4131 O O   . LEU C 3 356 ? 175.788 211.785 185.027 1.00 96.61  ? 400 LEU C O   1 
ATOM   4132 C CB  . LEU C 3 356 ? 174.816 210.196 187.501 1.00 96.61  ? 400 LEU C CB  1 
ATOM   4133 C CG  . LEU C 3 356 ? 174.203 211.071 188.598 1.00 96.61  ? 400 LEU C CG  1 
ATOM   4134 C CD1 . LEU C 3 356 ? 174.310 210.362 189.933 1.00 96.61  ? 400 LEU C CD1 1 
ATOM   4135 C CD2 . LEU C 3 356 ? 174.879 212.424 188.683 1.00 96.61  ? 400 LEU C CD2 1 
ATOM   4136 N N   . PRO C 3 357 ? 173.690 212.531 185.334 1.00 100.22 ? 401 PRO C N   1 
ATOM   4137 C CA  . PRO C 3 357 ? 173.971 213.795 184.642 1.00 100.22 ? 401 PRO C CA  1 
ATOM   4138 C C   . PRO C 3 357 ? 174.979 214.648 185.396 1.00 100.22 ? 401 PRO C C   1 
ATOM   4139 O O   . PRO C 3 357 ? 174.915 214.785 186.619 1.00 100.22 ? 401 PRO C O   1 
ATOM   4140 C CB  . PRO C 3 357 ? 172.599 214.478 184.578 1.00 100.22 ? 401 PRO C CB  1 
ATOM   4141 C CG  . PRO C 3 357 ? 171.816 213.860 185.690 1.00 100.22 ? 401 PRO C CG  1 
ATOM   4142 C CD  . PRO C 3 357 ? 172.289 212.441 185.780 1.00 100.22 ? 401 PRO C CD  1 
ATOM   4143 N N   . ASN C 3 358 ? 175.914 215.228 184.638 1.00 100.98 ? 402 ASN C N   1 
ATOM   4144 C CA  . ASN C 3 358 ? 176.954 216.106 185.175 1.00 100.98 ? 402 ASN C CA  1 
ATOM   4145 C C   . ASN C 3 358 ? 177.831 215.354 186.177 1.00 100.98 ? 402 ASN C C   1 
ATOM   4146 O O   . ASN C 3 358 ? 178.013 215.771 187.323 1.00 100.98 ? 402 ASN C O   1 
ATOM   4147 C CB  . ASN C 3 358 ? 176.343 217.367 185.799 1.00 100.98 ? 402 ASN C CB  1 
ATOM   4148 C CG  . ASN C 3 358 ? 177.375 218.450 186.091 1.00 100.98 ? 402 ASN C CG  1 
ATOM   4149 O OD1 . ASN C 3 358 ? 178.573 218.183 186.201 1.00 100.98 ? 402 ASN C OD1 1 
ATOM   4150 N ND2 . ASN C 3 358 ? 176.905 219.685 186.222 1.00 100.98 ? 402 ASN C ND2 1 
ATOM   4151 N N   . GLN C 3 359 ? 178.365 214.217 185.734 1.00 99.79  ? 403 GLN C N   1 
ATOM   4152 C CA  . GLN C 3 359 ? 179.320 213.449 186.524 1.00 99.79  ? 403 GLN C CA  1 
ATOM   4153 C C   . GLN C 3 359 ? 180.046 212.485 185.600 1.00 99.79  ? 403 GLN C C   1 
ATOM   4154 O O   . GLN C 3 359 ? 179.403 211.705 184.891 1.00 99.79  ? 403 GLN C O   1 
ATOM   4155 C CB  . GLN C 3 359 ? 178.628 212.684 187.658 1.00 99.79  ? 403 GLN C CB  1 
ATOM   4156 C CG  . GLN C 3 359 ? 179.600 212.020 188.617 1.00 99.79  ? 403 GLN C CG  1 
ATOM   4157 C CD  . GLN C 3 359 ? 178.927 211.491 189.865 1.00 99.79  ? 403 GLN C CD  1 
ATOM   4158 O OE1 . GLN C 3 359 ? 177.700 211.474 189.964 1.00 99.79  ? 403 GLN C OE1 1 
ATOM   4159 N NE2 . GLN C 3 359 ? 179.729 211.058 190.830 1.00 99.79  ? 403 GLN C NE2 1 
ATOM   4160 N N   . GLU C 3 360 ? 181.373 212.534 185.616 1.00 100.42 ? 404 GLU C N   1 
ATOM   4161 C CA  . GLU C 3 360 ? 182.190 211.707 184.735 1.00 100.42 ? 404 GLU C CA  1 
ATOM   4162 C C   . GLU C 3 360 ? 182.991 210.645 185.471 1.00 100.42 ? 404 GLU C C   1 
ATOM   4163 O O   . GLU C 3 360 ? 183.150 209.536 184.955 1.00 100.42 ? 404 GLU C O   1 
ATOM   4164 C CB  . GLU C 3 360 ? 183.146 212.589 183.919 1.00 100.42 ? 404 GLU C CB  1 
ATOM   4165 C CG  . GLU C 3 360 ? 183.908 213.608 184.747 1.00 100.42 ? 404 GLU C CG  1 
ATOM   4166 C CD  . GLU C 3 360 ? 184.839 214.457 183.908 1.00 100.42 ? 404 GLU C CD  1 
ATOM   4167 O OE1 . GLU C 3 360 ? 184.966 214.182 182.696 1.00 100.42 ? 404 GLU C OE1 1 
ATOM   4168 O OE2 . GLU C 3 360 ? 185.444 215.399 184.460 1.00 100.42 ? 404 GLU C OE2 1 
ATOM   4169 N N   . ILE C 3 361 ? 183.508 210.952 186.661 1.00 91.62  ? 405 ILE C N   1 
ATOM   4170 C CA  . ILE C 3 361 ? 184.292 209.976 187.405 1.00 91.62  ? 405 ILE C CA  1 
ATOM   4171 C C   . ILE C 3 361 ? 183.353 209.008 188.110 1.00 91.62  ? 405 ILE C C   1 
ATOM   4172 O O   . ILE C 3 361 ? 182.357 209.416 188.721 1.00 91.62  ? 405 ILE C O   1 
ATOM   4173 C CB  . ILE C 3 361 ? 185.225 210.681 188.400 1.00 91.62  ? 405 ILE C CB  1 
ATOM   4174 C CG1 . ILE C 3 361 ? 186.159 211.639 187.659 1.00 91.62  ? 405 ILE C CG1 1 
ATOM   4175 C CG2 . ILE C 3 361 ? 186.033 209.664 189.191 1.00 91.62  ? 405 ILE C CG2 1 
ATOM   4176 C CD1 . ILE C 3 361 ? 187.120 212.375 188.562 1.00 91.62  ? 405 ILE C CD1 1 
ATOM   4177 N N   . TYR C 3 362 ? 183.662 207.716 188.021 1.00 91.75  ? 406 TYR C N   1 
ATOM   4178 C CA  . TYR C 3 362 ? 182.837 206.669 188.602 1.00 91.75  ? 406 TYR C CA  1 
ATOM   4179 C C   . TYR C 3 362 ? 183.721 205.659 189.319 1.00 91.75  ? 406 TYR C C   1 
ATOM   4180 O O   . TYR C 3 362 ? 184.800 205.309 188.833 1.00 91.75  ? 406 TYR C O   1 
ATOM   4181 C CB  . TYR C 3 362 ? 182.000 205.966 187.529 1.00 91.75  ? 406 TYR C CB  1 
ATOM   4182 C CG  . TYR C 3 362 ? 180.780 206.745 187.093 1.00 91.75  ? 406 TYR C CG  1 
ATOM   4183 C CD1 . TYR C 3 362 ? 179.527 206.461 187.617 1.00 91.75  ? 406 TYR C CD1 1 
ATOM   4184 C CD2 . TYR C 3 362 ? 180.881 207.766 186.158 1.00 91.75  ? 406 TYR C CD2 1 
ATOM   4185 C CE1 . TYR C 3 362 ? 178.409 207.169 187.220 1.00 91.75  ? 406 TYR C CE1 1 
ATOM   4186 C CE2 . TYR C 3 362 ? 179.770 208.481 185.756 1.00 91.75  ? 406 TYR C CE2 1 
ATOM   4187 C CZ  . TYR C 3 362 ? 178.537 208.178 186.290 1.00 91.75  ? 406 TYR C CZ  1 
ATOM   4188 O OH  . TYR C 3 362 ? 177.427 208.887 185.892 1.00 91.75  ? 406 TYR C OH  1 
ATOM   4189 N N   . ASN C 3 363 ? 183.253 205.195 190.476 1.00 90.52  ? 407 ASN C N   1 
ATOM   4190 C CA  . ASN C 3 363 ? 183.974 204.231 191.306 1.00 90.52  ? 407 ASN C CA  1 
ATOM   4191 C C   . ASN C 3 363 ? 182.974 203.152 191.714 1.00 90.52  ? 407 ASN C C   1 
ATOM   4192 O O   . ASN C 3 363 ? 182.201 203.337 192.659 1.00 90.52  ? 407 ASN C O   1 
ATOM   4193 C CB  . ASN C 3 363 ? 184.604 204.924 192.514 1.00 90.52  ? 407 ASN C CB  1 
ATOM   4194 C CG  . ASN C 3 363 ? 185.018 203.958 193.613 1.00 90.52  ? 407 ASN C CG  1 
ATOM   4195 O OD1 . ASN C 3 363 ? 185.389 202.812 193.358 1.00 90.52  ? 407 ASN C OD1 1 
ATOM   4196 N ND2 . ASN C 3 363 ? 184.961 204.436 194.851 1.00 90.52  ? 407 ASN C ND2 1 
ATOM   4197 N N   . PHE C 3 364 ? 182.987 202.033 190.995 1.00 86.14  ? 408 PHE C N   1 
ATOM   4198 C CA  . PHE C 3 364 ? 182.020 200.961 191.185 1.00 86.14  ? 408 PHE C CA  1 
ATOM   4199 C C   . PHE C 3 364 ? 182.595 199.866 192.073 1.00 86.14  ? 408 PHE C C   1 
ATOM   4200 O O   . PHE C 3 364 ? 183.803 199.612 192.062 1.00 86.14  ? 408 PHE C O   1 
ATOM   4201 C CB  . PHE C 3 364 ? 181.604 200.356 189.842 1.00 86.14  ? 408 PHE C CB  1 
ATOM   4202 C CG  . PHE C 3 364 ? 180.827 201.292 188.965 1.00 86.14  ? 408 PHE C CG  1 
ATOM   4203 C CD1 . PHE C 3 364 ? 179.509 201.599 189.253 1.00 86.14  ? 408 PHE C CD1 1 
ATOM   4204 C CD2 . PHE C 3 364 ? 181.410 201.853 187.843 1.00 86.14  ? 408 PHE C CD2 1 
ATOM   4205 C CE1 . PHE C 3 364 ? 178.790 202.454 188.442 1.00 86.14  ? 408 PHE C CE1 1 
ATOM   4206 C CE2 . PHE C 3 364 ? 180.697 202.709 187.029 1.00 86.14  ? 408 PHE C CE2 1 
ATOM   4207 C CZ  . PHE C 3 364 ? 179.385 203.010 187.330 1.00 86.14  ? 408 PHE C CZ  1 
ATOM   4208 N N   . THR C 3 365 ? 181.719 199.221 192.841 1.00 77.19  ? 409 THR C N   1 
ATOM   4209 C CA  . THR C 3 365 ? 182.066 198.047 193.635 1.00 77.19  ? 409 THR C CA  1 
ATOM   4210 C C   . THR C 3 365 ? 180.962 197.014 193.467 1.00 77.19  ? 409 THR C C   1 
ATOM   4211 O O   . THR C 3 365 ? 179.800 197.290 193.782 1.00 77.19  ? 409 THR C O   1 
ATOM   4212 C CB  . THR C 3 365 ? 182.247 198.393 195.118 1.00 77.19  ? 409 THR C CB  1 
ATOM   4213 O OG1 . THR C 3 365 ? 180.995 198.817 195.670 1.00 77.19  ? 409 THR C OG1 1 
ATOM   4214 C CG2 . THR C 3 365 ? 183.283 199.494 195.304 1.00 77.19  ? 409 THR C CG2 1 
ATOM   4215 N N   . LEU C 3 366 ? 181.322 195.833 192.974 1.00 71.00  ? 410 LEU C N   1 
ATOM   4216 C CA  . LEU C 3 366 ? 180.376 194.745 192.765 1.00 71.00  ? 410 LEU C CA  1 
ATOM   4217 C C   . LEU C 3 366 ? 180.412 193.806 193.962 1.00 71.00  ? 410 LEU C C   1 
ATOM   4218 O O   . LEU C 3 366 ? 181.482 193.551 194.521 1.00 71.00  ? 410 LEU C O   1 
ATOM   4219 C CB  . LEU C 3 366 ? 180.699 193.978 191.482 1.00 71.00  ? 410 LEU C CB  1 
ATOM   4220 C CG  . LEU C 3 366 ? 179.604 193.064 190.924 1.00 71.00  ? 410 LEU C CG  1 
ATOM   4221 C CD1 . LEU C 3 366 ? 179.656 193.047 189.406 1.00 71.00  ? 410 LEU C CD1 1 
ATOM   4222 C CD2 . LEU C 3 366 ? 179.728 191.652 191.474 1.00 71.00  ? 410 LEU C CD2 1 
ATOM   4223 N N   . ASN C 3 367 ? 179.246 193.299 194.352 1.00 70.63  ? 411 ASN C N   1 
ATOM   4224 C CA  . ASN C 3 367 ? 179.121 192.390 195.483 1.00 70.63  ? 411 ASN C CA  1 
ATOM   4225 C C   . ASN C 3 367 ? 178.321 191.162 195.074 1.00 70.63  ? 411 ASN C C   1 
ATOM   4226 O O   . ASN C 3 367 ? 177.267 191.284 194.442 1.00 70.63  ? 411 ASN C O   1 
ATOM   4227 C CB  . ASN C 3 367 ? 178.449 193.086 196.669 1.00 70.63  ? 411 ASN C CB  1 
ATOM   4228 C CG  . ASN C 3 367 ? 179.244 194.271 197.174 1.00 70.63  ? 411 ASN C CG  1 
ATOM   4229 O OD1 . ASN C 3 367 ? 180.474 194.249 197.184 1.00 70.63  ? 411 ASN C OD1 1 
ATOM   4230 N ND2 . ASN C 3 367 ? 178.544 195.317 197.595 1.00 70.63  ? 411 ASN C ND2 1 
ATOM   4231 N N   . ALA C 3 368 ? 178.825 189.985 195.435 1.00 69.64  ? 412 ALA C N   1 
ATOM   4232 C CA  . ALA C 3 368 ? 178.135 188.724 195.215 1.00 69.64  ? 412 ALA C CA  1 
ATOM   4233 C C   . ALA C 3 368 ? 177.892 188.044 196.554 1.00 69.64  ? 412 ALA C C   1 
ATOM   4234 O O   . ALA C 3 368 ? 178.634 188.258 197.516 1.00 69.64  ? 412 ALA C O   1 
ATOM   4235 C CB  . ALA C 3 368 ? 178.938 187.798 194.296 1.00 69.64  ? 412 ALA C CB  1 
ATOM   4236 N N   . HIS C 3 369 ? 176.845 187.222 196.615 1.00 72.42  ? 413 HIS C N   1 
ATOM   4237 C CA  . HIS C 3 369 ? 176.472 186.589 197.874 1.00 72.42  ? 413 HIS C CA  1 
ATOM   4238 C C   . HIS C 3 369 ? 175.677 185.322 197.600 1.00 72.42  ? 413 HIS C C   1 
ATOM   4239 O O   . HIS C 3 369 ? 174.707 185.350 196.837 1.00 72.42  ? 413 HIS C O   1 
ATOM   4240 C CB  . HIS C 3 369 ? 175.655 187.548 198.747 1.00 72.42  ? 413 HIS C CB  1 
ATOM   4241 C CG  . HIS C 3 369 ? 175.480 187.080 200.157 1.00 72.42  ? 413 HIS C CG  1 
ATOM   4242 N ND1 . HIS C 3 369 ? 174.550 186.128 200.515 1.00 72.42  ? 413 HIS C ND1 1 
ATOM   4243 C CD2 . HIS C 3 369 ? 176.116 187.433 201.299 1.00 72.42  ? 413 HIS C CD2 1 
ATOM   4244 C CE1 . HIS C 3 369 ? 174.620 185.914 201.817 1.00 72.42  ? 413 HIS C CE1 1 
ATOM   4245 N NE2 . HIS C 3 369 ? 175.563 186.693 202.316 1.00 72.42  ? 413 HIS C NE2 1 
ATOM   4246 N N   . ASN C 3 370 ? 176.088 184.222 198.228 1.00 69.53  ? 414 ASN C N   1 
ATOM   4247 C CA  . ASN C 3 370 ? 175.366 182.957 198.186 1.00 69.53  ? 414 ASN C CA  1 
ATOM   4248 C C   . ASN C 3 370 ? 175.094 182.524 199.624 1.00 69.53  ? 414 ASN C C   1 
ATOM   4249 O O   . ASN C 3 370 ? 175.565 183.187 200.557 1.00 69.53  ? 414 ASN C O   1 
ATOM   4250 C CB  . ASN C 3 370 ? 176.166 181.905 197.409 1.00 69.53  ? 414 ASN C CB  1 
ATOM   4251 C CG  . ASN C 3 370 ? 177.499 181.580 198.055 1.00 69.53  ? 414 ASN C CG  1 
ATOM   4252 O OD1 . ASN C 3 370 ? 177.894 182.194 199.045 1.00 69.53  ? 414 ASN C OD1 1 
ATOM   4253 N ND2 . ASN C 3 370 ? 178.200 180.601 197.494 1.00 69.53  ? 414 ASN C ND2 1 
ATOM   4254 N N   . PRO C 3 371 ? 174.345 181.434 199.863 1.00 65.05  ? 415 PRO C N   1 
ATOM   4255 C CA  . PRO C 3 371 ? 174.104 181.008 201.251 1.00 65.05  ? 415 PRO C CA  1 
ATOM   4256 C C   . PRO C 3 371 ? 175.349 180.548 202.000 1.00 65.05  ? 415 PRO C C   1 
ATOM   4257 O O   . PRO C 3 371 ? 175.240 180.082 203.138 1.00 65.05  ? 415 PRO C O   1 
ATOM   4258 C CB  . PRO C 3 371 ? 173.105 179.856 201.092 1.00 65.05  ? 415 PRO C CB  1 
ATOM   4259 C CG  . PRO C 3 371 ? 172.406 180.145 199.822 1.00 65.05  ? 415 PRO C CG  1 
ATOM   4260 C CD  . PRO C 3 371 ? 173.446 180.739 198.923 1.00 65.05  ? 415 PRO C CD  1 
ATOM   4261 N N   . LEU C 3 372 ? 176.531 180.660 201.388 1.00 66.20  ? 416 LEU C N   1 
ATOM   4262 C CA  . LEU C 3 372 ? 177.761 180.196 202.013 1.00 66.20  ? 416 LEU C CA  1 
ATOM   4263 C C   . LEU C 3 372 ? 178.845 181.257 202.157 1.00 66.20  ? 416 LEU C C   1 
ATOM   4264 O O   . LEU C 3 372 ? 179.753 181.066 202.971 1.00 66.20  ? 416 LEU C O   1 
ATOM   4265 C CB  . LEU C 3 372 ? 178.343 179.008 201.230 1.00 66.20  ? 416 LEU C CB  1 
ATOM   4266 C CG  . LEU C 3 372 ? 177.509 177.726 201.260 1.00 66.20  ? 416 LEU C CG  1 
ATOM   4267 C CD1 . LEU C 3 372 ? 178.158 176.640 200.419 1.00 66.20  ? 416 LEU C CD1 1 
ATOM   4268 C CD2 . LEU C 3 372 ? 177.308 177.253 202.689 1.00 66.20  ? 416 LEU C CD2 1 
ATOM   4269 N N   . GLY C 3 373 ? 178.786 182.351 201.408 1.00 67.90  ? 417 GLY C N   1 
ATOM   4270 C CA  . GLY C 3 373 ? 179.826 183.357 201.514 1.00 67.90  ? 417 GLY C CA  1 
ATOM   4271 C C   . GLY C 3 373 ? 179.521 184.560 200.650 1.00 67.90  ? 417 GLY C C   1 
ATOM   4272 O O   . GLY C 3 373 ? 178.411 184.718 200.138 1.00 67.90  ? 417 GLY C O   1 
ATOM   4273 N N   . ARG C 3 374 ? 180.530 185.417 200.501 1.00 67.35  ? 418 ARG C N   1 
ATOM   4274 C CA  . ARG C 3 374 ? 180.392 186.631 199.710 1.00 67.35  ? 418 ARG C CA  1 
ATOM   4275 C C   . ARG C 3 374 ? 181.758 187.052 199.185 1.00 67.35  ? 418 ARG C C   1 
ATOM   4276 O O   . ARG C 3 374 ? 182.799 186.668 199.723 1.00 67.35  ? 418 ARG C O   1 
ATOM   4277 C CB  . ARG C 3 374 ? 179.756 187.763 200.527 1.00 67.35  ? 418 ARG C CB  1 
ATOM   4278 C CG  . ARG C 3 374 ? 180.753 188.736 201.133 1.00 67.35  ? 418 ARG C CG  1 
ATOM   4279 C CD  . ARG C 3 374 ? 180.067 190.007 201.602 1.00 67.35  ? 418 ARG C CD  1 
ATOM   4280 N NE  . ARG C 3 374 ? 181.001 191.123 201.709 1.00 67.35  ? 418 ARG C NE  1 
ATOM   4281 C CZ  . ARG C 3 374 ? 181.660 191.442 202.818 1.00 67.35  ? 418 ARG C CZ  1 
ATOM   4282 N NH1 . ARG C 3 374 ? 182.491 192.475 202.824 1.00 67.35  ? 418 ARG C NH1 1 
ATOM   4283 N NH2 . ARG C 3 374 ? 181.489 190.727 203.921 1.00 67.35  ? 418 ARG C NH2 1 
ATOM   4284 N N   . SER C 3 375 ? 181.738 187.848 198.116 1.00 69.24  ? 419 SER C N   1 
ATOM   4285 C CA  . SER C 3 375 ? 182.956 188.360 197.504 1.00 69.24  ? 419 SER C CA  1 
ATOM   4286 C C   . SER C 3 375 ? 182.665 189.723 196.894 1.00 69.24  ? 419 SER C C   1 
ATOM   4287 O O   . SER C 3 375 ? 181.508 190.083 196.660 1.00 69.24  ? 419 SER C O   1 
ATOM   4288 C CB  . SER C 3 375 ? 183.502 187.401 196.440 1.00 69.24  ? 419 SER C CB  1 
ATOM   4289 O OG  . SER C 3 375 ? 183.486 186.062 196.902 1.00 69.24  ? 419 SER C OG  1 
ATOM   4290 N N   . GLN C 3 376 ? 183.729 190.482 196.634 1.00 71.59  ? 420 GLN C N   1 
ATOM   4291 C CA  . GLN C 3 376 ? 183.575 191.830 196.106 1.00 71.59  ? 420 GLN C CA  1 
ATOM   4292 C C   . GLN C 3 376 ? 184.743 192.172 195.193 1.00 71.59  ? 420 GLN C C   1 
ATOM   4293 O O   . GLN C 3 376 ? 185.769 191.487 195.175 1.00 71.59  ? 420 GLN C O   1 
ATOM   4294 C CB  . GLN C 3 376 ? 183.468 192.866 197.229 1.00 71.59  ? 420 GLN C CB  1 
ATOM   4295 C CG  . GLN C 3 376 ? 184.806 193.281 197.810 1.00 71.59  ? 420 GLN C CG  1 
ATOM   4296 C CD  . GLN C 3 376 ? 184.705 194.524 198.668 1.00 71.59  ? 420 GLN C CD  1 
ATOM   4297 O OE1 . GLN C 3 376 ? 183.737 194.707 199.405 1.00 71.59  ? 420 GLN C OE1 1 
ATOM   4298 N NE2 . GLN C 3 376 ? 185.709 195.388 198.577 1.00 71.59  ? 420 GLN C NE2 1 
ATOM   4299 N N   . SER C 3 377 ? 184.569 193.253 194.433 1.00 72.58  ? 421 SER C N   1 
ATOM   4300 C CA  . SER C 3 377 ? 185.597 193.770 193.540 1.00 72.58  ? 421 SER C CA  1 
ATOM   4301 C C   . SER C 3 377 ? 185.339 195.252 193.307 1.00 72.58  ? 421 SER C C   1 
ATOM   4302 O O   . SER C 3 377 ? 184.184 195.681 193.248 1.00 72.58  ? 421 SER C O   1 
ATOM   4303 C CB  . SER C 3 377 ? 185.616 193.016 192.207 1.00 72.58  ? 421 SER C CB  1 
ATOM   4304 O OG  . SER C 3 377 ? 186.223 193.796 191.192 1.00 72.58  ? 421 SER C OG  1 
ATOM   4305 N N   . THR C 3 378 ? 186.415 196.024 193.170 1.00 80.14  ? 422 THR C N   1 
ATOM   4306 C CA  . THR C 3 378 ? 186.336 197.473 193.052 1.00 80.14  ? 422 THR C CA  1 
ATOM   4307 C C   . THR C 3 378 ? 187.107 197.944 191.824 1.00 80.14  ? 422 THR C C   1 
ATOM   4308 O O   . THR C 3 378 ? 188.167 197.405 191.494 1.00 80.14  ? 422 THR C O   1 
ATOM   4309 C CB  . THR C 3 378 ? 186.890 198.155 194.315 1.00 80.14  ? 422 THR C CB  1 
ATOM   4310 O OG1 . THR C 3 378 ? 186.145 197.721 195.458 1.00 80.14  ? 422 THR C OG1 1 
ATOM   4311 C CG2 . THR C 3 378 ? 186.795 199.671 194.209 1.00 80.14  ? 422 THR C CG2 1 
ATOM   4312 N N   . ILE C 3 379 ? 186.565 198.956 191.148 1.00 85.81  ? 423 ILE C N   1 
ATOM   4313 C CA  . ILE C 3 379 ? 187.200 199.529 189.963 1.00 85.81  ? 423 ILE C CA  1 
ATOM   4314 C C   . ILE C 3 379 ? 186.880 201.018 189.901 1.00 85.81  ? 423 ILE C C   1 
ATOM   4315 O O   . ILE C 3 379 ? 185.759 201.437 190.204 1.00 85.81  ? 423 ILE C O   1 
ATOM   4316 C CB  . ILE C 3 379 ? 186.752 198.813 188.670 1.00 85.81  ? 423 ILE C CB  1 
ATOM   4317 C CG1 . ILE C 3 379 ? 187.460 199.411 187.452 1.00 85.81  ? 423 ILE C CG1 1 
ATOM   4318 C CG2 . ILE C 3 379 ? 185.238 198.874 188.508 1.00 85.81  ? 423 ILE C CG2 1 
ATOM   4319 C CD1 . ILE C 3 379 ? 187.280 198.613 186.185 1.00 85.81  ? 423 ILE C CD1 1 
ATOM   4320 N N   . LEU C 3 380 ? 187.876 201.816 189.522 1.00 89.16  ? 424 LEU C N   1 
ATOM   4321 C CA  . LEU C 3 380 ? 187.720 203.248 189.301 1.00 89.16  ? 424 LEU C CA  1 
ATOM   4322 C C   . LEU C 3 380 ? 187.892 203.535 187.816 1.00 89.16  ? 424 LEU C C   1 
ATOM   4323 O O   . LEU C 3 380 ? 188.914 203.171 187.225 1.00 89.16  ? 424 LEU C O   1 
ATOM   4324 C CB  . LEU C 3 380 ? 188.740 204.045 190.117 1.00 89.16  ? 424 LEU C CB  1 
ATOM   4325 C CG  . LEU C 3 380 ? 188.740 205.560 189.912 1.00 89.16  ? 424 LEU C CG  1 
ATOM   4326 C CD1 . LEU C 3 380 ? 187.487 206.182 190.507 1.00 89.16  ? 424 LEU C CD1 1 
ATOM   4327 C CD2 . LEU C 3 380 ? 189.991 206.187 190.509 1.00 89.16  ? 424 LEU C CD2 1 
ATOM   4328 N N   . VAL C 3 381 ? 186.899 204.189 187.217 1.00 92.10  ? 425 VAL C N   1 
ATOM   4329 C CA  . VAL C 3 381 ? 186.841 204.367 185.772 1.00 92.10  ? 425 VAL C CA  1 
ATOM   4330 C C   . VAL C 3 381 ? 186.522 205.820 185.446 1.00 92.10  ? 425 VAL C C   1 
ATOM   4331 O O   . VAL C 3 381 ? 185.803 206.495 186.191 1.00 92.10  ? 425 VAL C O   1 
ATOM   4332 C CB  . VAL C 3 381 ? 185.801 203.418 185.134 1.00 92.10  ? 425 VAL C CB  1 
ATOM   4333 C CG1 . VAL C 3 381 ? 184.382 203.842 185.489 1.00 92.10  ? 425 VAL C CG1 1 
ATOM   4334 C CG2 . VAL C 3 381 ? 185.984 203.351 183.628 1.00 92.10  ? 425 VAL C CG2 1 
ATOM   4335 N N   . ASN C 3 382 ? 187.086 206.307 184.341 1.00 96.49  ? 426 ASN C N   1 
ATOM   4336 C CA  . ASN C 3 382 ? 186.732 207.598 183.761 1.00 96.49  ? 426 ASN C CA  1 
ATOM   4337 C C   . ASN C 3 382 ? 185.773 207.325 182.608 1.00 96.49  ? 426 ASN C C   1 
ATOM   4338 O O   . ASN C 3 382 ? 186.172 206.766 181.581 1.00 96.49  ? 426 ASN C O   1 
ATOM   4339 C CB  . ASN C 3 382 ? 187.977 208.345 183.287 1.00 96.49  ? 426 ASN C CB  1 
ATOM   4340 C CG  . ASN C 3 382 ? 187.708 209.811 182.992 1.00 96.49  ? 426 ASN C CG  1 
ATOM   4341 O OD1 . ASN C 3 382 ? 186.564 210.263 183.021 1.00 96.49  ? 426 ASN C OD1 1 
ATOM   4342 N ND2 . ASN C 3 382 ? 188.769 210.560 182.701 1.00 96.49  ? 426 ASN C ND2 1 
ATOM   4343 N N   . ILE C 3 383 ? 184.507 207.716 182.778 1.00 93.46  ? 427 ILE C N   1 
ATOM   4344 C CA  . ILE C 3 383 ? 183.475 207.328 181.821 1.00 93.46  ? 427 ILE C CA  1 
ATOM   4345 C C   . ILE C 3 383 ? 183.658 208.000 180.468 1.00 93.46  ? 427 ILE C C   1 
ATOM   4346 O O   . ILE C 3 383 ? 183.049 207.571 179.481 1.00 93.46  ? 427 ILE C O   1 
ATOM   4347 C CB  . ILE C 3 383 ? 182.077 207.633 182.388 1.00 93.46  ? 427 ILE C CB  1 
ATOM   4348 C CG1 . ILE C 3 383 ? 181.055 206.645 181.828 1.00 93.46  ? 427 ILE C CG1 1 
ATOM   4349 C CG2 . ILE C 3 383 ? 181.668 209.061 182.069 1.00 93.46  ? 427 ILE C CG2 1 
ATOM   4350 C CD1 . ILE C 3 383 ? 181.335 205.210 182.206 1.00 93.46  ? 427 ILE C CD1 1 
ATOM   4351 N N   . THR C 3 384 ? 184.485 209.041 180.388 1.00 98.14  ? 428 THR C N   1 
ATOM   4352 C CA  . THR C 3 384 ? 184.705 209.727 179.122 1.00 98.14  ? 428 THR C CA  1 
ATOM   4353 C C   . THR C 3 384 ? 185.670 208.986 178.208 1.00 98.14  ? 428 THR C C   1 
ATOM   4354 O O   . THR C 3 384 ? 185.513 209.048 176.984 1.00 98.14  ? 428 THR C O   1 
ATOM   4355 C CB  . THR C 3 384 ? 185.238 211.135 179.378 1.00 98.14  ? 428 THR C CB  1 
ATOM   4356 O OG1 . THR C 3 384 ? 186.592 211.046 179.833 1.00 98.14  ? 428 THR C OG1 1 
ATOM   4357 C CG2 . THR C 3 384 ? 184.399 211.836 180.434 1.00 98.14  ? 428 THR C CG2 1 
ATOM   4358 N N   . GLU C 3 385 ? 186.658 208.292 178.767 1.00 97.23  ? 429 GLU C N   1 
ATOM   4359 C CA  . GLU C 3 385 ? 187.655 207.579 177.982 1.00 97.23  ? 429 GLU C CA  1 
ATOM   4360 C C   . GLU C 3 385 ? 187.279 206.125 177.730 1.00 97.23  ? 429 GLU C C   1 
ATOM   4361 O O   . GLU C 3 385 ? 188.151 205.326 177.375 1.00 97.23  ? 429 GLU C O   1 
ATOM   4362 C CB  . GLU C 3 385 ? 189.016 207.652 178.676 1.00 97.23  ? 429 GLU C CB  1 
ATOM   4363 C CG  . GLU C 3 385 ? 189.505 209.069 178.920 1.00 97.23  ? 429 GLU C CG  1 
ATOM   4364 C CD  . GLU C 3 385 ? 190.668 209.123 179.888 1.00 97.23  ? 429 GLU C CD  1 
ATOM   4365 O OE1 . GLU C 3 385 ? 190.749 210.094 180.669 1.00 97.23  ? 429 GLU C OE1 1 
ATOM   4366 O OE2 . GLU C 3 385 ? 191.503 208.195 179.868 1.00 97.23  ? 429 GLU C OE2 1 
ATOM   4367 N N   . LYS C 3 386 ? 186.008 205.767 177.902 1.00 91.60  ? 430 LYS C N   1 
ATOM   4368 C CA  . LYS C 3 386 ? 185.562 204.397 177.689 1.00 91.60  ? 430 LYS C CA  1 
ATOM   4369 C C   . LYS C 3 386 ? 184.412 204.357 176.693 1.00 91.60  ? 430 LYS C C   1 
ATOM   4370 O O   . LYS C 3 386 ? 183.392 203.704 176.936 1.00 91.60  ? 430 LYS C O   1 
ATOM   4371 C CB  . LYS C 3 386 ? 185.146 203.753 179.013 1.00 91.60  ? 430 LYS C CB  1 
ATOM   4372 C CG  . LYS C 3 386 ? 186.284 203.599 180.006 1.00 91.60  ? 430 LYS C CG  1 
ATOM   4373 C CD  . LYS C 3 386 ? 187.442 202.829 179.394 1.00 91.60  ? 430 LYS C CD  1 
ATOM   4374 C CE  . LYS C 3 386 ? 188.617 202.735 180.354 1.00 91.60  ? 430 LYS C CE  1 
ATOM   4375 N NZ  . LYS C 3 386 ? 188.261 202.002 181.599 1.00 91.60  ? 430 LYS C NZ  1 
ATOM   4376 N N   . VAL C 3 387 ? 184.566 205.056 175.574 1.00 90.79  ? 431 VAL C N   1 
ATOM   4377 C CA  . VAL C 3 387 ? 183.538 205.091 174.543 1.00 90.79  ? 431 VAL C CA  1 
ATOM   4378 C C   . VAL C 3 387 ? 183.925 204.187 173.379 1.00 90.79  ? 431 VAL C C   1 
ATOM   4379 O O   . VAL C 3 387 ? 185.105 203.926 173.149 1.00 90.79  ? 431 VAL C O   1 
ATOM   4380 C CB  . VAL C 3 387 ? 183.291 206.527 174.058 1.00 90.79  ? 431 VAL C CB  1 
ATOM   4381 C CG1 . VAL C 3 387 ? 182.512 207.310 175.102 1.00 90.79  ? 431 VAL C CG1 1 
ATOM   4382 C CG2 . VAL C 3 387 ? 184.612 207.213 173.748 1.00 90.79  ? 431 VAL C CG2 1 
HETATM 4383 C C1  . NAG D 4 .   ? 138.926 170.274 175.596 1.00 76.33  ? 1   NAG D C1  1 
HETATM 4384 C C2  . NAG D 4 .   ? 137.609 170.820 175.034 1.00 76.33  ? 1   NAG D C2  1 
HETATM 4385 C C3  . NAG D 4 .   ? 137.676 172.337 174.889 1.00 76.33  ? 1   NAG D C3  1 
HETATM 4386 C C4  . NAG D 4 .   ? 138.064 172.970 176.217 1.00 76.33  ? 1   NAG D C4  1 
HETATM 4387 C C5  . NAG D 4 .   ? 139.386 172.382 176.695 1.00 76.33  ? 1   NAG D C5  1 
HETATM 4388 C C6  . NAG D 4 .   ? 139.813 172.904 178.047 1.00 76.33  ? 1   NAG D C6  1 
HETATM 4389 C C7  . NAG D 4 .   ? 136.222 169.407 173.584 1.00 76.33  ? 1   NAG D C7  1 
HETATM 4390 C C8  . NAG D 4 .   ? 136.040 168.848 172.206 1.00 76.33  ? 1   NAG D C8  1 
HETATM 4391 N N2  . NAG D 4 .   ? 137.286 170.198 173.761 1.00 76.33  ? 1   NAG D N2  1 
HETATM 4392 O O3  . NAG D 4 .   ? 136.408 172.825 174.468 1.00 76.33  ? 1   NAG D O3  1 
HETATM 4393 O O4  . NAG D 4 .   ? 138.147 174.390 176.126 1.00 76.33  ? 1   NAG D O4  1 
HETATM 4394 O O5  . NAG D 4 .   ? 139.255 170.958 176.823 1.00 76.33  ? 1   NAG D O5  1 
HETATM 4395 O O6  . NAG D 4 .   ? 141.117 173.466 177.999 1.00 76.33  ? 1   NAG D O6  1 
HETATM 4396 O O7  . NAG D 4 .   ? 135.442 169.154 174.497 1.00 76.33  ? 1   NAG D O7  1 
HETATM 4397 C C1  . NAG D 4 .   ? 138.910 174.848 174.993 1.00 90.51  ? 2   NAG D C1  1 
HETATM 4398 C C2  . NAG D 4 .   ? 138.150 176.012 174.361 1.00 90.51  ? 2   NAG D C2  1 
HETATM 4399 C C3  . NAG D 4 .   ? 138.937 176.583 173.186 1.00 90.51  ? 2   NAG D C3  1 
HETATM 4400 C C4  . NAG D 4 .   ? 140.348 176.951 173.623 1.00 90.51  ? 2   NAG D C4  1 
HETATM 4401 C C5  . NAG D 4 .   ? 141.023 175.753 174.284 1.00 90.51  ? 2   NAG D C5  1 
HETATM 4402 C C6  . NAG D 4 .   ? 142.383 176.081 174.854 1.00 90.51  ? 2   NAG D C6  1 
HETATM 4403 C C7  . NAG D 4 .   ? 135.711 175.908 174.614 1.00 90.51  ? 2   NAG D C7  1 
HETATM 4404 C C8  . NAG D 4 .   ? 134.424 175.405 174.031 1.00 90.51  ? 2   NAG D C8  1 
HETATM 4405 N N2  . NAG D 4 .   ? 136.821 175.602 173.935 1.00 90.51  ? 2   NAG D N2  1 
HETATM 4406 O O3  . NAG D 4 .   ? 138.269 177.733 172.682 1.00 90.51  ? 2   NAG D O3  1 
HETATM 4407 O O4  . NAG D 4 .   ? 141.115 177.359 172.496 1.00 90.51  ? 2   NAG D O4  1 
HETATM 4408 O O5  . NAG D 4 .   ? 140.221 175.280 175.376 1.00 90.51  ? 2   NAG D O5  1 
HETATM 4409 O O6  . NAG D 4 .   ? 143.329 176.337 173.824 1.00 90.51  ? 2   NAG D O6  1 
HETATM 4410 O O7  . NAG D 4 .   ? 135.742 176.562 175.651 1.00 90.51  ? 2   NAG D O7  1 
HETATM 4411 C C1  . NAG E 4 .   ? 185.306 203.706 196.042 1.00 97.25  ? 1   NAG E C1  1 
HETATM 4412 C C2  . NAG E 4 .   ? 186.204 204.598 196.911 1.00 97.25  ? 1   NAG E C2  1 
HETATM 4413 C C3  . NAG E 4 .   ? 186.423 203.969 198.285 1.00 97.25  ? 1   NAG E C3  1 
HETATM 4414 C C4  . NAG E 4 .   ? 185.083 203.664 198.937 1.00 97.25  ? 1   NAG E C4  1 
HETATM 4415 C C5  . NAG E 4 .   ? 184.280 202.745 198.027 1.00 97.25  ? 1   NAG E C5  1 
HETATM 4416 C C6  . NAG E 4 .   ? 182.903 202.435 198.566 1.00 97.25  ? 1   NAG E C6  1 
HETATM 4417 C C7  . NAG E 4 .   ? 188.019 206.068 196.158 1.00 97.25  ? 1   NAG E C7  1 
HETATM 4418 C C8  . NAG E 4 .   ? 189.338 206.145 195.449 1.00 97.25  ? 1   NAG E C8  1 
HETATM 4419 N N2  . NAG E 4 .   ? 187.477 204.850 196.256 1.00 97.25  ? 1   NAG E N2  1 
HETATM 4420 O O3  . NAG E 4 .   ? 187.171 204.866 199.098 1.00 97.25  ? 1   NAG E O3  1 
HETATM 4421 O O4  . NAG E 4 .   ? 185.236 203.086 200.230 1.00 97.25  ? 1   NAG E O4  1 
HETATM 4422 O O5  . NAG E 4 .   ? 184.092 203.387 196.757 1.00 97.25  ? 1   NAG E O5  1 
HETATM 4423 O O6  . NAG E 4 .   ? 182.261 201.424 197.801 1.00 97.25  ? 1   NAG E O6  1 
HETATM 4424 O O7  . NAG E 4 .   ? 187.469 207.063 196.619 1.00 97.25  ? 1   NAG E O7  1 
HETATM 4425 C C1  . NAG E 4 .   ? 186.185 202.003 200.255 1.00 99.83  ? 2   NAG E C1  1 
HETATM 4426 C C2  . NAG E 4 .   ? 186.981 202.118 201.553 1.00 99.83  ? 2   NAG E C2  1 
HETATM 4427 C C3  . NAG E 4 .   ? 187.971 200.964 201.670 1.00 99.83  ? 2   NAG E C3  1 
HETATM 4428 C C4  . NAG E 4 .   ? 187.254 199.630 201.511 1.00 99.83  ? 2   NAG E C4  1 
HETATM 4429 C C5  . NAG E 4 .   ? 186.443 199.618 200.219 1.00 99.83  ? 2   NAG E C5  1 
HETATM 4430 C C6  . NAG E 4 .   ? 185.604 198.372 200.059 1.00 99.83  ? 2   NAG E C6  1 
HETATM 4431 C C7  . NAG E 4 .   ? 187.172 204.459 202.269 1.00 99.83  ? 2   NAG E C7  1 
HETATM 4432 C C8  . NAG E 4 .   ? 188.020 205.695 202.250 1.00 99.83  ? 2   NAG E C8  1 
HETATM 4433 N N2  . NAG E 4 .   ? 187.672 203.395 201.632 1.00 99.83  ? 2   NAG E N2  1 
HETATM 4434 O O3  . NAG E 4 .   ? 188.616 201.021 202.938 1.00 99.83  ? 2   NAG E O3  1 
HETATM 4435 O O4  . NAG E 4 .   ? 188.201 198.569 201.481 1.00 99.83  ? 2   NAG E O4  1 
HETATM 4436 O O5  . NAG E 4 .   ? 185.537 200.731 200.200 1.00 99.83  ? 2   NAG E O5  1 
HETATM 4437 O O6  . NAG E 4 .   ? 185.849 197.738 198.812 1.00 99.83  ? 2   NAG E O6  1 
HETATM 4438 O O7  . NAG E 4 .   ? 186.084 204.425 202.835 1.00 99.83  ? 2   NAG E O7  1 
HETATM 4439 C C1  . NAG F 4 .   ? 188.657 211.967 182.401 1.00 108.64 ? 1   NAG F C1  1 
HETATM 4440 C C2  . NAG F 4 .   ? 189.847 212.746 182.959 1.00 108.64 ? 1   NAG F C2  1 
HETATM 4441 C C3  . NAG F 4 .   ? 189.705 214.230 182.635 1.00 108.64 ? 1   NAG F C3  1 
HETATM 4442 C C4  . NAG F 4 .   ? 189.511 214.429 181.137 1.00 108.64 ? 1   NAG F C4  1 
HETATM 4443 C C5  . NAG F 4 .   ? 188.340 213.584 180.642 1.00 108.64 ? 1   NAG F C5  1 
HETATM 4444 C C6  . NAG F 4 .   ? 188.166 213.634 179.142 1.00 108.64 ? 1   NAG F C6  1 
HETATM 4445 C C7  . NAG F 4 .   ? 191.045 211.968 184.954 1.00 108.64 ? 1   NAG F C7  1 
HETATM 4446 C C8  . NAG F 4 .   ? 191.015 211.842 186.447 1.00 108.64 ? 1   NAG F C8  1 
HETATM 4447 N N2  . NAG F 4 .   ? 189.978 212.545 184.393 1.00 108.64 ? 1   NAG F N2  1 
HETATM 4448 O O3  . NAG F 4 .   ? 190.868 214.924 183.072 1.00 108.64 ? 1   NAG F O3  1 
HETATM 4449 O O4  . NAG F 4 .   ? 189.251 215.800 180.859 1.00 108.64 ? 1   NAG F O4  1 
HETATM 4450 O O5  . NAG F 4 .   ? 188.545 212.205 180.988 1.00 108.64 ? 1   NAG F O5  1 
HETATM 4451 O O6  . NAG F 4 .   ? 188.202 212.333 178.572 1.00 108.64 ? 1   NAG F O6  1 
HETATM 4452 O O7  . NAG F 4 .   ? 191.993 211.567 184.285 1.00 108.64 ? 1   NAG F O7  1 
HETATM 4453 C C1  . NAG F 4 .   ? 190.313 216.335 180.040 1.00 118.50 ? 2   NAG F C1  1 
HETATM 4454 C C2  . NAG F 4 .   ? 189.714 217.361 179.076 1.00 118.50 ? 2   NAG F C2  1 
HETATM 4455 C C3  . NAG F 4 .   ? 190.813 217.992 178.227 1.00 118.50 ? 2   NAG F C3  1 
HETATM 4456 C C4  . NAG F 4 .   ? 191.909 218.563 179.116 1.00 118.50 ? 2   NAG F C4  1 
HETATM 4457 C C5  . NAG F 4 .   ? 192.420 217.491 180.075 1.00 118.50 ? 2   NAG F C5  1 
HETATM 4458 C C6  . NAG F 4 .   ? 193.431 218.018 181.067 1.00 118.50 ? 2   NAG F C6  1 
HETATM 4459 C C7  . NAG F 4 .   ? 187.399 217.058 178.306 1.00 118.50 ? 2   NAG F C7  1 
HETATM 4460 C C8  . NAG F 4 .   ? 187.021 218.083 179.334 1.00 118.50 ? 2   NAG F C8  1 
HETATM 4461 N N2  . NAG F 4 .   ? 188.699 216.754 178.230 1.00 118.50 ? 2   NAG F N2  1 
HETATM 4462 O O3  . NAG F 4 .   ? 190.255 219.021 177.418 1.00 118.50 ? 2   NAG F O3  1 
HETATM 4463 O O4  . NAG F 4 .   ? 192.989 219.033 178.317 1.00 118.50 ? 2   NAG F O4  1 
HETATM 4464 O O5  . NAG F 4 .   ? 191.328 216.960 180.839 1.00 118.50 ? 2   NAG F O5  1 
HETATM 4465 O O6  . NAG F 4 .   ? 194.369 217.016 181.433 1.00 118.50 ? 2   NAG F O6  1 
HETATM 4466 O O7  . NAG F 4 .   ? 186.565 216.529 177.578 1.00 118.50 ? 2   NAG F O7  1 
HETATM 4467 C C1  . NAG G 5 .   ? 158.251 170.605 141.068 1.00 117.08 ? 701 NAG B C1  1 
HETATM 4468 C C2  . NAG G 5 .   ? 157.317 169.403 141.229 1.00 117.08 ? 701 NAG B C2  1 
HETATM 4469 C C3  . NAG G 5 .   ? 157.274 168.569 139.945 1.00 117.08 ? 701 NAG B C3  1 
HETATM 4470 C C4  . NAG G 5 .   ? 158.675 168.262 139.426 1.00 117.08 ? 701 NAG B C4  1 
HETATM 4471 C C5  . NAG G 5 .   ? 159.544 169.515 139.420 1.00 117.08 ? 701 NAG B C5  1 
HETATM 4472 C C6  . NAG G 5 .   ? 160.173 169.793 138.075 1.00 117.08 ? 701 NAG B C6  1 
HETATM 4473 C C7  . NAG G 5 .   ? 156.888 168.258 143.358 1.00 117.08 ? 701 NAG B C7  1 
HETATM 4474 C C8  . NAG G 5 .   ? 157.469 167.401 144.442 1.00 117.08 ? 701 NAG B C8  1 
HETATM 4475 N N2  . NAG G 5 .   ? 157.717 168.580 142.359 1.00 117.08 ? 701 NAG B N2  1 
HETATM 4476 O O3  . NAG G 5 .   ? 156.531 169.267 138.952 1.00 117.08 ? 701 NAG B O3  1 
HETATM 4477 O O4  . NAG G 5 .   ? 159.289 167.271 140.243 1.00 117.08 ? 701 NAG B O4  1 
HETATM 4478 O O5  . NAG G 5 .   ? 158.739 170.655 139.742 1.00 117.08 ? 701 NAG B O5  1 
HETATM 4479 O O6  . NAG G 5 .   ? 160.326 171.188 137.852 1.00 117.08 ? 701 NAG B O6  1 
HETATM 4480 O O7  . NAG G 5 .   ? 155.723 168.641 143.385 1.00 117.08 ? 701 NAG B O7  1 
HETATM 4481 C C1  . NAG H 5 .   ? 178.215 148.970 165.835 1.00 97.19  ? 702 NAG B C1  1 
HETATM 4482 C C2  . NAG H 5 .   ? 177.867 150.403 166.246 1.00 97.19  ? 702 NAG B C2  1 
HETATM 4483 C C3  . NAG H 5 .   ? 177.686 150.507 167.763 1.00 97.19  ? 702 NAG B C3  1 
HETATM 4484 C C4  . NAG H 5 .   ? 178.847 149.861 168.513 1.00 97.19  ? 702 NAG B C4  1 
HETATM 4485 C C5  . NAG H 5 .   ? 179.171 148.486 167.938 1.00 97.19  ? 702 NAG B C5  1 
HETATM 4486 C C6  . NAG H 5 .   ? 179.176 147.394 168.982 1.00 97.19  ? 702 NAG B C6  1 
HETATM 4487 C C7  . NAG H 5 .   ? 178.888 151.865 164.558 1.00 97.19  ? 702 NAG B C7  1 
HETATM 4488 C C8  . NAG H 5 .   ? 180.010 152.813 164.256 1.00 97.19  ? 702 NAG B C8  1 
HETATM 4489 N N2  . NAG H 5 .   ? 178.882 151.338 165.787 1.00 97.19  ? 702 NAG B N2  1 
HETATM 4490 O O3  . NAG H 5 .   ? 176.462 149.885 168.135 1.00 97.19  ? 702 NAG B O3  1 
HETATM 4491 O O4  . NAG H 5 .   ? 180.001 150.688 168.427 1.00 97.19  ? 702 NAG B O4  1 
HETATM 4492 O O5  . NAG H 5 .   ? 178.179 148.127 166.969 1.00 97.19  ? 702 NAG B O5  1 
HETATM 4493 O O6  . NAG H 5 .   ? 178.376 146.290 168.581 1.00 97.19  ? 702 NAG B O6  1 
HETATM 4494 O O7  . NAG H 5 .   ? 178.028 151.590 163.728 1.00 97.19  ? 702 NAG B O7  1 
HETATM 4495 C C1  . NAG I 5 .   ? 159.957 192.247 153.841 1.00 110.78 ? 703 NAG B C1  1 
HETATM 4496 C C2  . NAG I 5 .   ? 160.222 193.404 154.807 1.00 110.78 ? 703 NAG B C2  1 
HETATM 4497 C C3  . NAG I 5 .   ? 158.962 194.247 154.988 1.00 110.78 ? 703 NAG B C3  1 
HETATM 4498 C C4  . NAG I 5 .   ? 158.423 194.692 153.635 1.00 110.78 ? 703 NAG B C4  1 
HETATM 4499 C C5  . NAG I 5 .   ? 158.234 193.487 152.717 1.00 110.78 ? 703 NAG B C5  1 
HETATM 4500 C C6  . NAG I 5 .   ? 157.817 193.873 151.316 1.00 110.78 ? 703 NAG B C6  1 
HETATM 4501 C C7  . NAG I 5 .   ? 160.043 192.140 156.929 1.00 110.78 ? 703 NAG B C7  1 
HETATM 4502 C C8  . NAG I 5 .   ? 160.746 191.780 158.202 1.00 110.78 ? 703 NAG B C8  1 
HETATM 4503 N N2  . NAG I 5 .   ? 160.723 192.935 156.092 1.00 110.78 ? 703 NAG B N2  1 
HETATM 4504 O O3  . NAG I 5 .   ? 159.262 195.382 155.791 1.00 110.78 ? 703 NAG B O3  1 
HETATM 4505 O O4  . NAG I 5 .   ? 157.174 195.352 153.802 1.00 110.78 ? 703 NAG B O4  1 
HETATM 4506 O O5  . NAG I 5 .   ? 159.468 192.763 152.597 1.00 110.78 ? 703 NAG B O5  1 
HETATM 4507 O O6  . NAG I 5 .   ? 157.476 195.250 151.237 1.00 110.78 ? 703 NAG B O6  1 
HETATM 4508 O O7  . NAG I 5 .   ? 158.915 191.727 156.672 1.00 110.78 ? 703 NAG B O7  1 
HETATM 4509 C C1  . NAG J 5 .   ? 189.077 163.888 200.891 1.00 78.31  ? 901 NAG C C1  1 
HETATM 4510 C C2  . NAG J 5 .   ? 190.435 164.109 201.554 1.00 78.31  ? 901 NAG C C2  1 
HETATM 4511 C C3  . NAG J 5 .   ? 191.410 164.735 200.561 1.00 78.31  ? 901 NAG C C3  1 
HETATM 4512 C C4  . NAG J 5 .   ? 191.483 163.900 199.289 1.00 78.31  ? 901 NAG C C4  1 
HETATM 4513 C C5  . NAG J 5 .   ? 190.084 163.681 198.720 1.00 78.31  ? 901 NAG C C5  1 
HETATM 4514 C C6  . NAG J 5 .   ? 190.071 162.758 197.524 1.00 78.31  ? 901 NAG C C6  1 
HETATM 4515 C C7  . NAG J 5 .   ? 190.414 164.461 203.982 1.00 78.31  ? 901 NAG C C7  1 
HETATM 4516 C C8  . NAG J 5 .   ? 190.254 165.461 205.088 1.00 78.31  ? 901 NAG C C8  1 
HETATM 4517 N N2  . NAG J 5 .   ? 190.308 164.941 202.739 1.00 78.31  ? 901 NAG C N2  1 
HETATM 4518 O O3  . NAG J 5 .   ? 192.699 164.826 201.157 1.00 78.31  ? 901 NAG C O3  1 
HETATM 4519 O O4  . NAG J 5 .   ? 192.286 164.561 198.318 1.00 78.31  ? 901 NAG C O4  1 
HETATM 4520 O O5  . NAG J 5 .   ? 189.239 163.084 199.715 1.00 78.31  ? 901 NAG C O5  1 
HETATM 4521 O O6  . NAG J 5 .   ? 189.118 161.716 197.683 1.00 78.31  ? 901 NAG C O6  1 
HETATM 4522 O O7  . NAG J 5 .   ? 190.630 163.274 204.205 1.00 78.31  ? 901 NAG C O7  1 
# 
