data_8UYV
# 
_entry.id   8UYV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8UYV         pdb_00008uyv 10.2210/pdb8uyv/pdb 
WWPDB D_1000276224 ?            ?                   
EMDB  EMD-42824    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8UYV 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB . EMD-42822 'other EM volume'      
EMDB . EMD-42823 'other EM volume'      
EMDB . EMD-42825 'other EM volume'      
EMDB . EMD-42826 'other EM volume'      
EMDB . EMD-42827 'other EM volume'      
EMDB . EMD-42828 'other EM volume'      
EMDB . EMD-42824 'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              joewang@psu.edu 
_pdbx_contact_author.name_first         'Joseph CY' 
_pdbx_contact_author.name_last          Wang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6580-3531 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bianchini, E.N.' 1 0000-0003-2787-6240 
'Wang, J.C.Y.'    2 0000-0001-6580-3531 
'Hu, J.'          3 0000-0002-3967-2133 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural Insights into Capsid Conformation and Dynamics: Cryo-EM Structures of HBV Capsids from HEK-293T Cells' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bianchini, E.N.' 1 0000-0003-2787-6240 
primary 'Liu, H.'         2 0000-0002-6263-1508 
primary 'Cai, Y.'         3 ?                   
primary 'Shanklin, J.'    4 0000-0002-6774-8043 
primary 'Hu, J.'          5 ?                   
primary 'Wang, J.C.Y.'    6 0000-0001-6580-3531 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Capsid protein' 
_entity.formula_weight             21108.254 
_entity.pdbx_number_of_molecules   4 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              'S155A, S162A, S170A' 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Core antigen,Core protein,HBcAg,p21.5' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGVNLEDPA
SRDLVVSYVNTNMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRAPRRRT
PAPRRRRSQAPRRRRSQSREPQC
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGVNLEDPA
SRDLVVSYVNTNMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRAPRRRT
PAPRRRRSQAPRRRRSQSREPQC
;
_entity_poly.pdbx_strand_id                 A,B,C,D 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   ILE n 
1 4   ASP n 
1 5   PRO n 
1 6   TYR n 
1 7   LYS n 
1 8   GLU n 
1 9   PHE n 
1 10  GLY n 
1 11  ALA n 
1 12  THR n 
1 13  VAL n 
1 14  GLU n 
1 15  LEU n 
1 16  LEU n 
1 17  SER n 
1 18  PHE n 
1 19  LEU n 
1 20  PRO n 
1 21  SER n 
1 22  ASP n 
1 23  PHE n 
1 24  PHE n 
1 25  PRO n 
1 26  SER n 
1 27  VAL n 
1 28  ARG n 
1 29  ASP n 
1 30  LEU n 
1 31  LEU n 
1 32  ASP n 
1 33  THR n 
1 34  ALA n 
1 35  SER n 
1 36  ALA n 
1 37  LEU n 
1 38  TYR n 
1 39  ARG n 
1 40  GLU n 
1 41  ALA n 
1 42  LEU n 
1 43  GLU n 
1 44  SER n 
1 45  PRO n 
1 46  GLU n 
1 47  HIS n 
1 48  CYS n 
1 49  SER n 
1 50  PRO n 
1 51  HIS n 
1 52  HIS n 
1 53  THR n 
1 54  ALA n 
1 55  LEU n 
1 56  ARG n 
1 57  GLN n 
1 58  ALA n 
1 59  ILE n 
1 60  LEU n 
1 61  CYS n 
1 62  TRP n 
1 63  GLY n 
1 64  GLU n 
1 65  LEU n 
1 66  MET n 
1 67  THR n 
1 68  LEU n 
1 69  ALA n 
1 70  THR n 
1 71  TRP n 
1 72  VAL n 
1 73  GLY n 
1 74  VAL n 
1 75  ASN n 
1 76  LEU n 
1 77  GLU n 
1 78  ASP n 
1 79  PRO n 
1 80  ALA n 
1 81  SER n 
1 82  ARG n 
1 83  ASP n 
1 84  LEU n 
1 85  VAL n 
1 86  VAL n 
1 87  SER n 
1 88  TYR n 
1 89  VAL n 
1 90  ASN n 
1 91  THR n 
1 92  ASN n 
1 93  MET n 
1 94  GLY n 
1 95  LEU n 
1 96  LYS n 
1 97  PHE n 
1 98  ARG n 
1 99  GLN n 
1 100 LEU n 
1 101 LEU n 
1 102 TRP n 
1 103 PHE n 
1 104 HIS n 
1 105 ILE n 
1 106 SER n 
1 107 CYS n 
1 108 LEU n 
1 109 THR n 
1 110 PHE n 
1 111 GLY n 
1 112 ARG n 
1 113 GLU n 
1 114 THR n 
1 115 VAL n 
1 116 ILE n 
1 117 GLU n 
1 118 TYR n 
1 119 LEU n 
1 120 VAL n 
1 121 SER n 
1 122 PHE n 
1 123 GLY n 
1 124 VAL n 
1 125 TRP n 
1 126 ILE n 
1 127 ARG n 
1 128 THR n 
1 129 PRO n 
1 130 PRO n 
1 131 ALA n 
1 132 TYR n 
1 133 ARG n 
1 134 PRO n 
1 135 PRO n 
1 136 ASN n 
1 137 ALA n 
1 138 PRO n 
1 139 ILE n 
1 140 LEU n 
1 141 SER n 
1 142 THR n 
1 143 LEU n 
1 144 PRO n 
1 145 GLU n 
1 146 THR n 
1 147 THR n 
1 148 VAL n 
1 149 VAL n 
1 150 ARG n 
1 151 ARG n 
1 152 ARG n 
1 153 GLY n 
1 154 ARG n 
1 155 ALA n 
1 156 PRO n 
1 157 ARG n 
1 158 ARG n 
1 159 ARG n 
1 160 THR n 
1 161 PRO n 
1 162 ALA n 
1 163 PRO n 
1 164 ARG n 
1 165 ARG n 
1 166 ARG n 
1 167 ARG n 
1 168 SER n 
1 169 GLN n 
1 170 ALA n 
1 171 PRO n 
1 172 ARG n 
1 173 ARG n 
1 174 ARG n 
1 175 ARG n 
1 176 SER n 
1 177 GLN n 
1 178 SER n 
1 179 ARG n 
1 180 GLU n 
1 181 PRO n 
1 182 GLN n 
1 183 CYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   183 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'pre-c/core, C, core, pre-C/C, PreC, preC, preC/C, precore-core, HBVgp4' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Hepatitis B virus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10407 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            HEK-293T 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ASP 2   2   2   ASP ASP A . n 
A 1 3   ILE 3   3   3   ILE ILE A . n 
A 1 4   ASP 4   4   4   ASP ASP A . n 
A 1 5   PRO 5   5   5   PRO PRO A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   LYS 7   7   7   LYS LYS A . n 
A 1 8   GLU 8   8   8   GLU GLU A . n 
A 1 9   PHE 9   9   9   PHE PHE A . n 
A 1 10  GLY 10  10  10  GLY GLY A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  SER 17  17  17  SER SER A . n 
A 1 18  PHE 18  18  18  PHE PHE A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  PRO 20  20  20  PRO PRO A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  ASP 22  22  22  ASP ASP A . n 
A 1 23  PHE 23  23  23  PHE PHE A . n 
A 1 24  PHE 24  24  24  PHE PHE A . n 
A 1 25  PRO 25  25  25  PRO PRO A . n 
A 1 26  SER 26  26  26  SER SER A . n 
A 1 27  VAL 27  27  27  VAL VAL A . n 
A 1 28  ARG 28  28  28  ARG ARG A . n 
A 1 29  ASP 29  29  29  ASP ASP A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ASP 32  32  32  ASP ASP A . n 
A 1 33  THR 33  33  33  THR THR A . n 
A 1 34  ALA 34  34  34  ALA ALA A . n 
A 1 35  SER 35  35  35  SER SER A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  TYR 38  38  38  TYR TYR A . n 
A 1 39  ARG 39  39  39  ARG ARG A . n 
A 1 40  GLU 40  40  40  GLU GLU A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  SER 44  44  44  SER SER A . n 
A 1 45  PRO 45  45  45  PRO PRO A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  HIS 47  47  47  HIS HIS A . n 
A 1 48  CYS 48  48  48  CYS CYS A . n 
A 1 49  SER 49  49  49  SER SER A . n 
A 1 50  PRO 50  50  50  PRO PRO A . n 
A 1 51  HIS 51  51  51  HIS HIS A . n 
A 1 52  HIS 52  52  52  HIS HIS A . n 
A 1 53  THR 53  53  53  THR THR A . n 
A 1 54  ALA 54  54  54  ALA ALA A . n 
A 1 55  LEU 55  55  55  LEU LEU A . n 
A 1 56  ARG 56  56  56  ARG ARG A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  LEU 60  60  60  LEU LEU A . n 
A 1 61  CYS 61  61  61  CYS CYS A . n 
A 1 62  TRP 62  62  62  TRP TRP A . n 
A 1 63  GLY 63  63  63  GLY GLY A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  MET 66  66  66  MET MET A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  LEU 68  68  68  LEU LEU A . n 
A 1 69  ALA 69  69  69  ALA ALA A . n 
A 1 70  THR 70  70  70  THR THR A . n 
A 1 71  TRP 71  71  71  TRP TRP A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  VAL 74  74  74  VAL VAL A . n 
A 1 75  ASN 75  75  75  ASN ASN A . n 
A 1 76  LEU 76  76  76  LEU LEU A . n 
A 1 77  GLU 77  77  77  GLU GLU A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  PRO 79  79  79  PRO PRO A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  ARG 82  82  82  ARG ARG A . n 
A 1 83  ASP 83  83  83  ASP ASP A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  VAL 85  85  85  VAL VAL A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  SER 87  87  87  SER SER A . n 
A 1 88  TYR 88  88  88  TYR TYR A . n 
A 1 89  VAL 89  89  89  VAL VAL A . n 
A 1 90  ASN 90  90  90  ASN ASN A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  ASN 92  92  92  ASN ASN A . n 
A 1 93  MET 93  93  93  MET MET A . n 
A 1 94  GLY 94  94  94  GLY GLY A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  LYS 96  96  96  LYS LYS A . n 
A 1 97  PHE 97  97  97  PHE PHE A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  GLN 99  99  99  GLN GLN A . n 
A 1 100 LEU 100 100 100 LEU LEU A . n 
A 1 101 LEU 101 101 101 LEU LEU A . n 
A 1 102 TRP 102 102 102 TRP TRP A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 HIS 104 104 104 HIS HIS A . n 
A 1 105 ILE 105 105 105 ILE ILE A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 CYS 107 107 107 CYS CYS A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 THR 109 109 109 THR THR A . n 
A 1 110 PHE 110 110 110 PHE PHE A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ARG 112 112 112 ARG ARG A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 THR 114 114 114 THR THR A . n 
A 1 115 VAL 115 115 115 VAL VAL A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 GLU 117 117 117 GLU GLU A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 VAL 124 124 124 VAL VAL A . n 
A 1 125 TRP 125 125 125 TRP TRP A . n 
A 1 126 ILE 126 126 126 ILE ILE A . n 
A 1 127 ARG 127 127 127 ARG ARG A . n 
A 1 128 THR 128 128 128 THR THR A . n 
A 1 129 PRO 129 129 129 PRO PRO A . n 
A 1 130 PRO 130 130 130 PRO PRO A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 TYR 132 132 132 TYR TYR A . n 
A 1 133 ARG 133 133 133 ARG ARG A . n 
A 1 134 PRO 134 134 134 PRO PRO A . n 
A 1 135 PRO 135 135 135 PRO PRO A . n 
A 1 136 ASN 136 136 136 ASN ASN A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 PRO 138 138 138 PRO PRO A . n 
A 1 139 ILE 139 139 139 ILE ILE A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 SER 141 141 141 SER SER A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 PRO 144 144 144 PRO PRO A . n 
A 1 145 GLU 145 145 ?   ?   ?   A . n 
A 1 146 THR 146 146 ?   ?   ?   A . n 
A 1 147 THR 147 147 ?   ?   ?   A . n 
A 1 148 VAL 148 148 ?   ?   ?   A . n 
A 1 149 VAL 149 149 ?   ?   ?   A . n 
A 1 150 ARG 150 150 ?   ?   ?   A . n 
A 1 151 ARG 151 151 ?   ?   ?   A . n 
A 1 152 ARG 152 152 ?   ?   ?   A . n 
A 1 153 GLY 153 153 ?   ?   ?   A . n 
A 1 154 ARG 154 154 ?   ?   ?   A . n 
A 1 155 ALA 155 155 ?   ?   ?   A . n 
A 1 156 PRO 156 156 ?   ?   ?   A . n 
A 1 157 ARG 157 157 ?   ?   ?   A . n 
A 1 158 ARG 158 158 ?   ?   ?   A . n 
A 1 159 ARG 159 159 ?   ?   ?   A . n 
A 1 160 THR 160 160 ?   ?   ?   A . n 
A 1 161 PRO 161 161 ?   ?   ?   A . n 
A 1 162 ALA 162 162 ?   ?   ?   A . n 
A 1 163 PRO 163 163 ?   ?   ?   A . n 
A 1 164 ARG 164 164 ?   ?   ?   A . n 
A 1 165 ARG 165 165 ?   ?   ?   A . n 
A 1 166 ARG 166 166 ?   ?   ?   A . n 
A 1 167 ARG 167 167 ?   ?   ?   A . n 
A 1 168 SER 168 168 ?   ?   ?   A . n 
A 1 169 GLN 169 169 ?   ?   ?   A . n 
A 1 170 ALA 170 170 ?   ?   ?   A . n 
A 1 171 PRO 171 171 ?   ?   ?   A . n 
A 1 172 ARG 172 172 ?   ?   ?   A . n 
A 1 173 ARG 173 173 ?   ?   ?   A . n 
A 1 174 ARG 174 174 ?   ?   ?   A . n 
A 1 175 ARG 175 175 ?   ?   ?   A . n 
A 1 176 SER 176 176 ?   ?   ?   A . n 
A 1 177 GLN 177 177 ?   ?   ?   A . n 
A 1 178 SER 178 178 ?   ?   ?   A . n 
A 1 179 ARG 179 179 ?   ?   ?   A . n 
A 1 180 GLU 180 180 ?   ?   ?   A . n 
A 1 181 PRO 181 181 ?   ?   ?   A . n 
A 1 182 GLN 182 182 ?   ?   ?   A . n 
A 1 183 CYS 183 183 ?   ?   ?   A . n 
B 1 1   MET 1   1   1   MET MET B . n 
B 1 2   ASP 2   2   2   ASP ASP B . n 
B 1 3   ILE 3   3   3   ILE ILE B . n 
B 1 4   ASP 4   4   4   ASP ASP B . n 
B 1 5   PRO 5   5   5   PRO PRO B . n 
B 1 6   TYR 6   6   6   TYR TYR B . n 
B 1 7   LYS 7   7   7   LYS LYS B . n 
B 1 8   GLU 8   8   8   GLU GLU B . n 
B 1 9   PHE 9   9   9   PHE PHE B . n 
B 1 10  GLY 10  10  10  GLY GLY B . n 
B 1 11  ALA 11  11  11  ALA ALA B . n 
B 1 12  THR 12  12  12  THR THR B . n 
B 1 13  VAL 13  13  13  VAL VAL B . n 
B 1 14  GLU 14  14  14  GLU GLU B . n 
B 1 15  LEU 15  15  15  LEU LEU B . n 
B 1 16  LEU 16  16  16  LEU LEU B . n 
B 1 17  SER 17  17  17  SER SER B . n 
B 1 18  PHE 18  18  18  PHE PHE B . n 
B 1 19  LEU 19  19  19  LEU LEU B . n 
B 1 20  PRO 20  20  20  PRO PRO B . n 
B 1 21  SER 21  21  21  SER SER B . n 
B 1 22  ASP 22  22  22  ASP ASP B . n 
B 1 23  PHE 23  23  23  PHE PHE B . n 
B 1 24  PHE 24  24  24  PHE PHE B . n 
B 1 25  PRO 25  25  25  PRO PRO B . n 
B 1 26  SER 26  26  26  SER SER B . n 
B 1 27  VAL 27  27  27  VAL VAL B . n 
B 1 28  ARG 28  28  28  ARG ARG B . n 
B 1 29  ASP 29  29  29  ASP ASP B . n 
B 1 30  LEU 30  30  30  LEU LEU B . n 
B 1 31  LEU 31  31  31  LEU LEU B . n 
B 1 32  ASP 32  32  32  ASP ASP B . n 
B 1 33  THR 33  33  33  THR THR B . n 
B 1 34  ALA 34  34  34  ALA ALA B . n 
B 1 35  SER 35  35  35  SER SER B . n 
B 1 36  ALA 36  36  36  ALA ALA B . n 
B 1 37  LEU 37  37  37  LEU LEU B . n 
B 1 38  TYR 38  38  38  TYR TYR B . n 
B 1 39  ARG 39  39  39  ARG ARG B . n 
B 1 40  GLU 40  40  40  GLU GLU B . n 
B 1 41  ALA 41  41  41  ALA ALA B . n 
B 1 42  LEU 42  42  42  LEU LEU B . n 
B 1 43  GLU 43  43  43  GLU GLU B . n 
B 1 44  SER 44  44  44  SER SER B . n 
B 1 45  PRO 45  45  45  PRO PRO B . n 
B 1 46  GLU 46  46  46  GLU GLU B . n 
B 1 47  HIS 47  47  47  HIS HIS B . n 
B 1 48  CYS 48  48  48  CYS CYS B . n 
B 1 49  SER 49  49  49  SER SER B . n 
B 1 50  PRO 50  50  50  PRO PRO B . n 
B 1 51  HIS 51  51  51  HIS HIS B . n 
B 1 52  HIS 52  52  52  HIS HIS B . n 
B 1 53  THR 53  53  53  THR THR B . n 
B 1 54  ALA 54  54  54  ALA ALA B . n 
B 1 55  LEU 55  55  55  LEU LEU B . n 
B 1 56  ARG 56  56  56  ARG ARG B . n 
B 1 57  GLN 57  57  57  GLN GLN B . n 
B 1 58  ALA 58  58  58  ALA ALA B . n 
B 1 59  ILE 59  59  59  ILE ILE B . n 
B 1 60  LEU 60  60  60  LEU LEU B . n 
B 1 61  CYS 61  61  61  CYS CYS B . n 
B 1 62  TRP 62  62  62  TRP TRP B . n 
B 1 63  GLY 63  63  63  GLY GLY B . n 
B 1 64  GLU 64  64  64  GLU GLU B . n 
B 1 65  LEU 65  65  65  LEU LEU B . n 
B 1 66  MET 66  66  66  MET MET B . n 
B 1 67  THR 67  67  67  THR THR B . n 
B 1 68  LEU 68  68  68  LEU LEU B . n 
B 1 69  ALA 69  69  69  ALA ALA B . n 
B 1 70  THR 70  70  70  THR THR B . n 
B 1 71  TRP 71  71  71  TRP TRP B . n 
B 1 72  VAL 72  72  72  VAL VAL B . n 
B 1 73  GLY 73  73  73  GLY GLY B . n 
B 1 74  VAL 74  74  74  VAL VAL B . n 
B 1 75  ASN 75  75  75  ASN ASN B . n 
B 1 76  LEU 76  76  76  LEU LEU B . n 
B 1 77  GLU 77  77  77  GLU GLU B . n 
B 1 78  ASP 78  78  78  ASP ASP B . n 
B 1 79  PRO 79  79  79  PRO PRO B . n 
B 1 80  ALA 80  80  80  ALA ALA B . n 
B 1 81  SER 81  81  81  SER SER B . n 
B 1 82  ARG 82  82  82  ARG ARG B . n 
B 1 83  ASP 83  83  83  ASP ASP B . n 
B 1 84  LEU 84  84  84  LEU LEU B . n 
B 1 85  VAL 85  85  85  VAL VAL B . n 
B 1 86  VAL 86  86  86  VAL VAL B . n 
B 1 87  SER 87  87  87  SER SER B . n 
B 1 88  TYR 88  88  88  TYR TYR B . n 
B 1 89  VAL 89  89  89  VAL VAL B . n 
B 1 90  ASN 90  90  90  ASN ASN B . n 
B 1 91  THR 91  91  91  THR THR B . n 
B 1 92  ASN 92  92  92  ASN ASN B . n 
B 1 93  MET 93  93  93  MET MET B . n 
B 1 94  GLY 94  94  94  GLY GLY B . n 
B 1 95  LEU 95  95  95  LEU LEU B . n 
B 1 96  LYS 96  96  96  LYS LYS B . n 
B 1 97  PHE 97  97  97  PHE PHE B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  GLN 99  99  99  GLN GLN B . n 
B 1 100 LEU 100 100 100 LEU LEU B . n 
B 1 101 LEU 101 101 101 LEU LEU B . n 
B 1 102 TRP 102 102 102 TRP TRP B . n 
B 1 103 PHE 103 103 103 PHE PHE B . n 
B 1 104 HIS 104 104 104 HIS HIS B . n 
B 1 105 ILE 105 105 105 ILE ILE B . n 
B 1 106 SER 106 106 106 SER SER B . n 
B 1 107 CYS 107 107 107 CYS CYS B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 THR 109 109 109 THR THR B . n 
B 1 110 PHE 110 110 110 PHE PHE B . n 
B 1 111 GLY 111 111 111 GLY GLY B . n 
B 1 112 ARG 112 112 112 ARG ARG B . n 
B 1 113 GLU 113 113 113 GLU GLU B . n 
B 1 114 THR 114 114 114 THR THR B . n 
B 1 115 VAL 115 115 115 VAL VAL B . n 
B 1 116 ILE 116 116 116 ILE ILE B . n 
B 1 117 GLU 117 117 117 GLU GLU B . n 
B 1 118 TYR 118 118 118 TYR TYR B . n 
B 1 119 LEU 119 119 119 LEU LEU B . n 
B 1 120 VAL 120 120 120 VAL VAL B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 PHE 122 122 122 PHE PHE B . n 
B 1 123 GLY 123 123 123 GLY GLY B . n 
B 1 124 VAL 124 124 124 VAL VAL B . n 
B 1 125 TRP 125 125 125 TRP TRP B . n 
B 1 126 ILE 126 126 126 ILE ILE B . n 
B 1 127 ARG 127 127 127 ARG ARG B . n 
B 1 128 THR 128 128 128 THR THR B . n 
B 1 129 PRO 129 129 129 PRO PRO B . n 
B 1 130 PRO 130 130 130 PRO PRO B . n 
B 1 131 ALA 131 131 131 ALA ALA B . n 
B 1 132 TYR 132 132 132 TYR TYR B . n 
B 1 133 ARG 133 133 133 ARG ARG B . n 
B 1 134 PRO 134 134 134 PRO PRO B . n 
B 1 135 PRO 135 135 135 PRO PRO B . n 
B 1 136 ASN 136 136 136 ASN ASN B . n 
B 1 137 ALA 137 137 137 ALA ALA B . n 
B 1 138 PRO 138 138 138 PRO PRO B . n 
B 1 139 ILE 139 139 139 ILE ILE B . n 
B 1 140 LEU 140 140 140 LEU LEU B . n 
B 1 141 SER 141 141 141 SER SER B . n 
B 1 142 THR 142 142 142 THR THR B . n 
B 1 143 LEU 143 143 143 LEU LEU B . n 
B 1 144 PRO 144 144 144 PRO PRO B . n 
B 1 145 GLU 145 145 145 GLU GLU B . n 
B 1 146 THR 146 146 146 THR THR B . n 
B 1 147 THR 147 147 147 THR THR B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 VAL 149 149 149 VAL VAL B . n 
B 1 150 ARG 150 150 150 ARG ARG B . n 
B 1 151 ARG 151 151 151 ARG ARG B . n 
B 1 152 ARG 152 152 152 ARG ARG B . n 
B 1 153 GLY 153 153 ?   ?   ?   B . n 
B 1 154 ARG 154 154 ?   ?   ?   B . n 
B 1 155 ALA 155 155 ?   ?   ?   B . n 
B 1 156 PRO 156 156 ?   ?   ?   B . n 
B 1 157 ARG 157 157 ?   ?   ?   B . n 
B 1 158 ARG 158 158 ?   ?   ?   B . n 
B 1 159 ARG 159 159 ?   ?   ?   B . n 
B 1 160 THR 160 160 ?   ?   ?   B . n 
B 1 161 PRO 161 161 ?   ?   ?   B . n 
B 1 162 ALA 162 162 ?   ?   ?   B . n 
B 1 163 PRO 163 163 ?   ?   ?   B . n 
B 1 164 ARG 164 164 ?   ?   ?   B . n 
B 1 165 ARG 165 165 ?   ?   ?   B . n 
B 1 166 ARG 166 166 ?   ?   ?   B . n 
B 1 167 ARG 167 167 ?   ?   ?   B . n 
B 1 168 SER 168 168 ?   ?   ?   B . n 
B 1 169 GLN 169 169 ?   ?   ?   B . n 
B 1 170 ALA 170 170 ?   ?   ?   B . n 
B 1 171 PRO 171 171 ?   ?   ?   B . n 
B 1 172 ARG 172 172 ?   ?   ?   B . n 
B 1 173 ARG 173 173 ?   ?   ?   B . n 
B 1 174 ARG 174 174 ?   ?   ?   B . n 
B 1 175 ARG 175 175 ?   ?   ?   B . n 
B 1 176 SER 176 176 ?   ?   ?   B . n 
B 1 177 GLN 177 177 ?   ?   ?   B . n 
B 1 178 SER 178 178 ?   ?   ?   B . n 
B 1 179 ARG 179 179 ?   ?   ?   B . n 
B 1 180 GLU 180 180 ?   ?   ?   B . n 
B 1 181 PRO 181 181 ?   ?   ?   B . n 
B 1 182 GLN 182 182 ?   ?   ?   B . n 
B 1 183 CYS 183 183 ?   ?   ?   B . n 
C 1 1   MET 1   1   1   MET MET C . n 
C 1 2   ASP 2   2   2   ASP ASP C . n 
C 1 3   ILE 3   3   3   ILE ILE C . n 
C 1 4   ASP 4   4   4   ASP ASP C . n 
C 1 5   PRO 5   5   5   PRO PRO C . n 
C 1 6   TYR 6   6   6   TYR TYR C . n 
C 1 7   LYS 7   7   7   LYS LYS C . n 
C 1 8   GLU 8   8   8   GLU GLU C . n 
C 1 9   PHE 9   9   9   PHE PHE C . n 
C 1 10  GLY 10  10  10  GLY GLY C . n 
C 1 11  ALA 11  11  11  ALA ALA C . n 
C 1 12  THR 12  12  12  THR THR C . n 
C 1 13  VAL 13  13  13  VAL VAL C . n 
C 1 14  GLU 14  14  14  GLU GLU C . n 
C 1 15  LEU 15  15  15  LEU LEU C . n 
C 1 16  LEU 16  16  16  LEU LEU C . n 
C 1 17  SER 17  17  17  SER SER C . n 
C 1 18  PHE 18  18  18  PHE PHE C . n 
C 1 19  LEU 19  19  19  LEU LEU C . n 
C 1 20  PRO 20  20  20  PRO PRO C . n 
C 1 21  SER 21  21  21  SER SER C . n 
C 1 22  ASP 22  22  22  ASP ASP C . n 
C 1 23  PHE 23  23  23  PHE PHE C . n 
C 1 24  PHE 24  24  24  PHE PHE C . n 
C 1 25  PRO 25  25  25  PRO PRO C . n 
C 1 26  SER 26  26  26  SER SER C . n 
C 1 27  VAL 27  27  27  VAL VAL C . n 
C 1 28  ARG 28  28  28  ARG ARG C . n 
C 1 29  ASP 29  29  29  ASP ASP C . n 
C 1 30  LEU 30  30  30  LEU LEU C . n 
C 1 31  LEU 31  31  31  LEU LEU C . n 
C 1 32  ASP 32  32  32  ASP ASP C . n 
C 1 33  THR 33  33  33  THR THR C . n 
C 1 34  ALA 34  34  34  ALA ALA C . n 
C 1 35  SER 35  35  35  SER SER C . n 
C 1 36  ALA 36  36  36  ALA ALA C . n 
C 1 37  LEU 37  37  37  LEU LEU C . n 
C 1 38  TYR 38  38  38  TYR TYR C . n 
C 1 39  ARG 39  39  39  ARG ARG C . n 
C 1 40  GLU 40  40  40  GLU GLU C . n 
C 1 41  ALA 41  41  41  ALA ALA C . n 
C 1 42  LEU 42  42  42  LEU LEU C . n 
C 1 43  GLU 43  43  43  GLU GLU C . n 
C 1 44  SER 44  44  44  SER SER C . n 
C 1 45  PRO 45  45  45  PRO PRO C . n 
C 1 46  GLU 46  46  46  GLU GLU C . n 
C 1 47  HIS 47  47  47  HIS HIS C . n 
C 1 48  CYS 48  48  48  CYS CYS C . n 
C 1 49  SER 49  49  49  SER SER C . n 
C 1 50  PRO 50  50  50  PRO PRO C . n 
C 1 51  HIS 51  51  51  HIS HIS C . n 
C 1 52  HIS 52  52  52  HIS HIS C . n 
C 1 53  THR 53  53  53  THR THR C . n 
C 1 54  ALA 54  54  54  ALA ALA C . n 
C 1 55  LEU 55  55  55  LEU LEU C . n 
C 1 56  ARG 56  56  56  ARG ARG C . n 
C 1 57  GLN 57  57  57  GLN GLN C . n 
C 1 58  ALA 58  58  58  ALA ALA C . n 
C 1 59  ILE 59  59  59  ILE ILE C . n 
C 1 60  LEU 60  60  60  LEU LEU C . n 
C 1 61  CYS 61  61  61  CYS CYS C . n 
C 1 62  TRP 62  62  62  TRP TRP C . n 
C 1 63  GLY 63  63  63  GLY GLY C . n 
C 1 64  GLU 64  64  64  GLU GLU C . n 
C 1 65  LEU 65  65  65  LEU LEU C . n 
C 1 66  MET 66  66  66  MET MET C . n 
C 1 67  THR 67  67  67  THR THR C . n 
C 1 68  LEU 68  68  68  LEU LEU C . n 
C 1 69  ALA 69  69  69  ALA ALA C . n 
C 1 70  THR 70  70  70  THR THR C . n 
C 1 71  TRP 71  71  71  TRP TRP C . n 
C 1 72  VAL 72  72  72  VAL VAL C . n 
C 1 73  GLY 73  73  73  GLY GLY C . n 
C 1 74  VAL 74  74  74  VAL VAL C . n 
C 1 75  ASN 75  75  75  ASN ASN C . n 
C 1 76  LEU 76  76  76  LEU LEU C . n 
C 1 77  GLU 77  77  77  GLU GLU C . n 
C 1 78  ASP 78  78  78  ASP ASP C . n 
C 1 79  PRO 79  79  79  PRO PRO C . n 
C 1 80  ALA 80  80  80  ALA ALA C . n 
C 1 81  SER 81  81  81  SER SER C . n 
C 1 82  ARG 82  82  82  ARG ARG C . n 
C 1 83  ASP 83  83  83  ASP ASP C . n 
C 1 84  LEU 84  84  84  LEU LEU C . n 
C 1 85  VAL 85  85  85  VAL VAL C . n 
C 1 86  VAL 86  86  86  VAL VAL C . n 
C 1 87  SER 87  87  87  SER SER C . n 
C 1 88  TYR 88  88  88  TYR TYR C . n 
C 1 89  VAL 89  89  89  VAL VAL C . n 
C 1 90  ASN 90  90  90  ASN ASN C . n 
C 1 91  THR 91  91  91  THR THR C . n 
C 1 92  ASN 92  92  92  ASN ASN C . n 
C 1 93  MET 93  93  93  MET MET C . n 
C 1 94  GLY 94  94  94  GLY GLY C . n 
C 1 95  LEU 95  95  95  LEU LEU C . n 
C 1 96  LYS 96  96  96  LYS LYS C . n 
C 1 97  PHE 97  97  97  PHE PHE C . n 
C 1 98  ARG 98  98  98  ARG ARG C . n 
C 1 99  GLN 99  99  99  GLN GLN C . n 
C 1 100 LEU 100 100 100 LEU LEU C . n 
C 1 101 LEU 101 101 101 LEU LEU C . n 
C 1 102 TRP 102 102 102 TRP TRP C . n 
C 1 103 PHE 103 103 103 PHE PHE C . n 
C 1 104 HIS 104 104 104 HIS HIS C . n 
C 1 105 ILE 105 105 105 ILE ILE C . n 
C 1 106 SER 106 106 106 SER SER C . n 
C 1 107 CYS 107 107 107 CYS CYS C . n 
C 1 108 LEU 108 108 108 LEU LEU C . n 
C 1 109 THR 109 109 109 THR THR C . n 
C 1 110 PHE 110 110 110 PHE PHE C . n 
C 1 111 GLY 111 111 111 GLY GLY C . n 
C 1 112 ARG 112 112 112 ARG ARG C . n 
C 1 113 GLU 113 113 113 GLU GLU C . n 
C 1 114 THR 114 114 114 THR THR C . n 
C 1 115 VAL 115 115 115 VAL VAL C . n 
C 1 116 ILE 116 116 116 ILE ILE C . n 
C 1 117 GLU 117 117 117 GLU GLU C . n 
C 1 118 TYR 118 118 118 TYR TYR C . n 
C 1 119 LEU 119 119 119 LEU LEU C . n 
C 1 120 VAL 120 120 120 VAL VAL C . n 
C 1 121 SER 121 121 121 SER SER C . n 
C 1 122 PHE 122 122 122 PHE PHE C . n 
C 1 123 GLY 123 123 123 GLY GLY C . n 
C 1 124 VAL 124 124 124 VAL VAL C . n 
C 1 125 TRP 125 125 125 TRP TRP C . n 
C 1 126 ILE 126 126 126 ILE ILE C . n 
C 1 127 ARG 127 127 127 ARG ARG C . n 
C 1 128 THR 128 128 128 THR THR C . n 
C 1 129 PRO 129 129 129 PRO PRO C . n 
C 1 130 PRO 130 130 130 PRO PRO C . n 
C 1 131 ALA 131 131 131 ALA ALA C . n 
C 1 132 TYR 132 132 132 TYR TYR C . n 
C 1 133 ARG 133 133 133 ARG ARG C . n 
C 1 134 PRO 134 134 134 PRO PRO C . n 
C 1 135 PRO 135 135 135 PRO PRO C . n 
C 1 136 ASN 136 136 136 ASN ASN C . n 
C 1 137 ALA 137 137 137 ALA ALA C . n 
C 1 138 PRO 138 138 138 PRO PRO C . n 
C 1 139 ILE 139 139 139 ILE ILE C . n 
C 1 140 LEU 140 140 140 LEU LEU C . n 
C 1 141 SER 141 141 141 SER SER C . n 
C 1 142 THR 142 142 142 THR THR C . n 
C 1 143 LEU 143 143 143 LEU LEU C . n 
C 1 144 PRO 144 144 144 PRO PRO C . n 
C 1 145 GLU 145 145 145 GLU GLU C . n 
C 1 146 THR 146 146 146 THR THR C . n 
C 1 147 THR 147 147 ?   ?   ?   C . n 
C 1 148 VAL 148 148 ?   ?   ?   C . n 
C 1 149 VAL 149 149 ?   ?   ?   C . n 
C 1 150 ARG 150 150 ?   ?   ?   C . n 
C 1 151 ARG 151 151 ?   ?   ?   C . n 
C 1 152 ARG 152 152 ?   ?   ?   C . n 
C 1 153 GLY 153 153 ?   ?   ?   C . n 
C 1 154 ARG 154 154 ?   ?   ?   C . n 
C 1 155 ALA 155 155 ?   ?   ?   C . n 
C 1 156 PRO 156 156 ?   ?   ?   C . n 
C 1 157 ARG 157 157 ?   ?   ?   C . n 
C 1 158 ARG 158 158 ?   ?   ?   C . n 
C 1 159 ARG 159 159 ?   ?   ?   C . n 
C 1 160 THR 160 160 ?   ?   ?   C . n 
C 1 161 PRO 161 161 ?   ?   ?   C . n 
C 1 162 ALA 162 162 ?   ?   ?   C . n 
C 1 163 PRO 163 163 ?   ?   ?   C . n 
C 1 164 ARG 164 164 ?   ?   ?   C . n 
C 1 165 ARG 165 165 ?   ?   ?   C . n 
C 1 166 ARG 166 166 ?   ?   ?   C . n 
C 1 167 ARG 167 167 ?   ?   ?   C . n 
C 1 168 SER 168 168 ?   ?   ?   C . n 
C 1 169 GLN 169 169 ?   ?   ?   C . n 
C 1 170 ALA 170 170 ?   ?   ?   C . n 
C 1 171 PRO 171 171 ?   ?   ?   C . n 
C 1 172 ARG 172 172 ?   ?   ?   C . n 
C 1 173 ARG 173 173 ?   ?   ?   C . n 
C 1 174 ARG 174 174 ?   ?   ?   C . n 
C 1 175 ARG 175 175 ?   ?   ?   C . n 
C 1 176 SER 176 176 ?   ?   ?   C . n 
C 1 177 GLN 177 177 ?   ?   ?   C . n 
C 1 178 SER 178 178 ?   ?   ?   C . n 
C 1 179 ARG 179 179 ?   ?   ?   C . n 
C 1 180 GLU 180 180 ?   ?   ?   C . n 
C 1 181 PRO 181 181 ?   ?   ?   C . n 
C 1 182 GLN 182 182 ?   ?   ?   C . n 
C 1 183 CYS 183 183 ?   ?   ?   C . n 
D 1 1   MET 1   1   1   MET MET D . n 
D 1 2   ASP 2   2   2   ASP ASP D . n 
D 1 3   ILE 3   3   3   ILE ILE D . n 
D 1 4   ASP 4   4   4   ASP ASP D . n 
D 1 5   PRO 5   5   5   PRO PRO D . n 
D 1 6   TYR 6   6   6   TYR TYR D . n 
D 1 7   LYS 7   7   7   LYS LYS D . n 
D 1 8   GLU 8   8   8   GLU GLU D . n 
D 1 9   PHE 9   9   9   PHE PHE D . n 
D 1 10  GLY 10  10  10  GLY GLY D . n 
D 1 11  ALA 11  11  11  ALA ALA D . n 
D 1 12  THR 12  12  12  THR THR D . n 
D 1 13  VAL 13  13  13  VAL VAL D . n 
D 1 14  GLU 14  14  14  GLU GLU D . n 
D 1 15  LEU 15  15  15  LEU LEU D . n 
D 1 16  LEU 16  16  16  LEU LEU D . n 
D 1 17  SER 17  17  17  SER SER D . n 
D 1 18  PHE 18  18  18  PHE PHE D . n 
D 1 19  LEU 19  19  19  LEU LEU D . n 
D 1 20  PRO 20  20  20  PRO PRO D . n 
D 1 21  SER 21  21  21  SER SER D . n 
D 1 22  ASP 22  22  22  ASP ASP D . n 
D 1 23  PHE 23  23  23  PHE PHE D . n 
D 1 24  PHE 24  24  24  PHE PHE D . n 
D 1 25  PRO 25  25  25  PRO PRO D . n 
D 1 26  SER 26  26  26  SER SER D . n 
D 1 27  VAL 27  27  27  VAL VAL D . n 
D 1 28  ARG 28  28  28  ARG ARG D . n 
D 1 29  ASP 29  29  29  ASP ASP D . n 
D 1 30  LEU 30  30  30  LEU LEU D . n 
D 1 31  LEU 31  31  31  LEU LEU D . n 
D 1 32  ASP 32  32  32  ASP ASP D . n 
D 1 33  THR 33  33  33  THR THR D . n 
D 1 34  ALA 34  34  34  ALA ALA D . n 
D 1 35  SER 35  35  35  SER SER D . n 
D 1 36  ALA 36  36  36  ALA ALA D . n 
D 1 37  LEU 37  37  37  LEU LEU D . n 
D 1 38  TYR 38  38  38  TYR TYR D . n 
D 1 39  ARG 39  39  39  ARG ARG D . n 
D 1 40  GLU 40  40  40  GLU GLU D . n 
D 1 41  ALA 41  41  41  ALA ALA D . n 
D 1 42  LEU 42  42  42  LEU LEU D . n 
D 1 43  GLU 43  43  43  GLU GLU D . n 
D 1 44  SER 44  44  44  SER SER D . n 
D 1 45  PRO 45  45  45  PRO PRO D . n 
D 1 46  GLU 46  46  46  GLU GLU D . n 
D 1 47  HIS 47  47  47  HIS HIS D . n 
D 1 48  CYS 48  48  48  CYS CYS D . n 
D 1 49  SER 49  49  49  SER SER D . n 
D 1 50  PRO 50  50  50  PRO PRO D . n 
D 1 51  HIS 51  51  51  HIS HIS D . n 
D 1 52  HIS 52  52  52  HIS HIS D . n 
D 1 53  THR 53  53  53  THR THR D . n 
D 1 54  ALA 54  54  54  ALA ALA D . n 
D 1 55  LEU 55  55  55  LEU LEU D . n 
D 1 56  ARG 56  56  56  ARG ARG D . n 
D 1 57  GLN 57  57  57  GLN GLN D . n 
D 1 58  ALA 58  58  58  ALA ALA D . n 
D 1 59  ILE 59  59  59  ILE ILE D . n 
D 1 60  LEU 60  60  60  LEU LEU D . n 
D 1 61  CYS 61  61  61  CYS CYS D . n 
D 1 62  TRP 62  62  62  TRP TRP D . n 
D 1 63  GLY 63  63  63  GLY GLY D . n 
D 1 64  GLU 64  64  64  GLU GLU D . n 
D 1 65  LEU 65  65  65  LEU LEU D . n 
D 1 66  MET 66  66  66  MET MET D . n 
D 1 67  THR 67  67  67  THR THR D . n 
D 1 68  LEU 68  68  68  LEU LEU D . n 
D 1 69  ALA 69  69  69  ALA ALA D . n 
D 1 70  THR 70  70  70  THR THR D . n 
D 1 71  TRP 71  71  71  TRP TRP D . n 
D 1 72  VAL 72  72  72  VAL VAL D . n 
D 1 73  GLY 73  73  73  GLY GLY D . n 
D 1 74  VAL 74  74  74  VAL VAL D . n 
D 1 75  ASN 75  75  75  ASN ASN D . n 
D 1 76  LEU 76  76  76  LEU LEU D . n 
D 1 77  GLU 77  77  77  GLU GLU D . n 
D 1 78  ASP 78  78  78  ASP ASP D . n 
D 1 79  PRO 79  79  79  PRO PRO D . n 
D 1 80  ALA 80  80  80  ALA ALA D . n 
D 1 81  SER 81  81  81  SER SER D . n 
D 1 82  ARG 82  82  82  ARG ARG D . n 
D 1 83  ASP 83  83  83  ASP ASP D . n 
D 1 84  LEU 84  84  84  LEU LEU D . n 
D 1 85  VAL 85  85  85  VAL VAL D . n 
D 1 86  VAL 86  86  86  VAL VAL D . n 
D 1 87  SER 87  87  87  SER SER D . n 
D 1 88  TYR 88  88  88  TYR TYR D . n 
D 1 89  VAL 89  89  89  VAL VAL D . n 
D 1 90  ASN 90  90  90  ASN ASN D . n 
D 1 91  THR 91  91  91  THR THR D . n 
D 1 92  ASN 92  92  92  ASN ASN D . n 
D 1 93  MET 93  93  93  MET MET D . n 
D 1 94  GLY 94  94  94  GLY GLY D . n 
D 1 95  LEU 95  95  95  LEU LEU D . n 
D 1 96  LYS 96  96  96  LYS LYS D . n 
D 1 97  PHE 97  97  97  PHE PHE D . n 
D 1 98  ARG 98  98  98  ARG ARG D . n 
D 1 99  GLN 99  99  99  GLN GLN D . n 
D 1 100 LEU 100 100 100 LEU LEU D . n 
D 1 101 LEU 101 101 101 LEU LEU D . n 
D 1 102 TRP 102 102 102 TRP TRP D . n 
D 1 103 PHE 103 103 103 PHE PHE D . n 
D 1 104 HIS 104 104 104 HIS HIS D . n 
D 1 105 ILE 105 105 105 ILE ILE D . n 
D 1 106 SER 106 106 106 SER SER D . n 
D 1 107 CYS 107 107 107 CYS CYS D . n 
D 1 108 LEU 108 108 108 LEU LEU D . n 
D 1 109 THR 109 109 109 THR THR D . n 
D 1 110 PHE 110 110 110 PHE PHE D . n 
D 1 111 GLY 111 111 111 GLY GLY D . n 
D 1 112 ARG 112 112 112 ARG ARG D . n 
D 1 113 GLU 113 113 113 GLU GLU D . n 
D 1 114 THR 114 114 114 THR THR D . n 
D 1 115 VAL 115 115 115 VAL VAL D . n 
D 1 116 ILE 116 116 116 ILE ILE D . n 
D 1 117 GLU 117 117 117 GLU GLU D . n 
D 1 118 TYR 118 118 118 TYR TYR D . n 
D 1 119 LEU 119 119 119 LEU LEU D . n 
D 1 120 VAL 120 120 120 VAL VAL D . n 
D 1 121 SER 121 121 121 SER SER D . n 
D 1 122 PHE 122 122 122 PHE PHE D . n 
D 1 123 GLY 123 123 123 GLY GLY D . n 
D 1 124 VAL 124 124 124 VAL VAL D . n 
D 1 125 TRP 125 125 125 TRP TRP D . n 
D 1 126 ILE 126 126 126 ILE ILE D . n 
D 1 127 ARG 127 127 127 ARG ARG D . n 
D 1 128 THR 128 128 128 THR THR D . n 
D 1 129 PRO 129 129 129 PRO PRO D . n 
D 1 130 PRO 130 130 130 PRO PRO D . n 
D 1 131 ALA 131 131 131 ALA ALA D . n 
D 1 132 TYR 132 132 132 TYR TYR D . n 
D 1 133 ARG 133 133 133 ARG ARG D . n 
D 1 134 PRO 134 134 134 PRO PRO D . n 
D 1 135 PRO 135 135 135 PRO PRO D . n 
D 1 136 ASN 136 136 136 ASN ASN D . n 
D 1 137 ALA 137 137 137 ALA ALA D . n 
D 1 138 PRO 138 138 138 PRO PRO D . n 
D 1 139 ILE 139 139 139 ILE ILE D . n 
D 1 140 LEU 140 140 140 LEU LEU D . n 
D 1 141 SER 141 141 141 SER SER D . n 
D 1 142 THR 142 142 142 THR THR D . n 
D 1 143 LEU 143 143 143 LEU LEU D . n 
D 1 144 PRO 144 144 144 PRO PRO D . n 
D 1 145 GLU 145 145 145 GLU GLU D . n 
D 1 146 THR 146 146 146 THR THR D . n 
D 1 147 THR 147 147 147 THR THR D . n 
D 1 148 VAL 148 148 148 VAL VAL D . n 
D 1 149 VAL 149 149 149 VAL VAL D . n 
D 1 150 ARG 150 150 150 ARG ARG D . n 
D 1 151 ARG 151 151 151 ARG ARG D . n 
D 1 152 ARG 152 152 152 ARG ARG D . n 
D 1 153 GLY 153 153 ?   ?   ?   D . n 
D 1 154 ARG 154 154 ?   ?   ?   D . n 
D 1 155 ALA 155 155 ?   ?   ?   D . n 
D 1 156 PRO 156 156 ?   ?   ?   D . n 
D 1 157 ARG 157 157 ?   ?   ?   D . n 
D 1 158 ARG 158 158 ?   ?   ?   D . n 
D 1 159 ARG 159 159 ?   ?   ?   D . n 
D 1 160 THR 160 160 ?   ?   ?   D . n 
D 1 161 PRO 161 161 ?   ?   ?   D . n 
D 1 162 ALA 162 162 ?   ?   ?   D . n 
D 1 163 PRO 163 163 ?   ?   ?   D . n 
D 1 164 ARG 164 164 ?   ?   ?   D . n 
D 1 165 ARG 165 165 ?   ?   ?   D . n 
D 1 166 ARG 166 166 ?   ?   ?   D . n 
D 1 167 ARG 167 167 ?   ?   ?   D . n 
D 1 168 SER 168 168 ?   ?   ?   D . n 
D 1 169 GLN 169 169 ?   ?   ?   D . n 
D 1 170 ALA 170 170 ?   ?   ?   D . n 
D 1 171 PRO 171 171 ?   ?   ?   D . n 
D 1 172 ARG 172 172 ?   ?   ?   D . n 
D 1 173 ARG 173 173 ?   ?   ?   D . n 
D 1 174 ARG 174 174 ?   ?   ?   D . n 
D 1 175 ARG 175 175 ?   ?   ?   D . n 
D 1 176 SER 176 176 ?   ?   ?   D . n 
D 1 177 GLN 177 177 ?   ?   ?   D . n 
D 1 178 SER 178 178 ?   ?   ?   D . n 
D 1 179 ARG 179 179 ?   ?   ?   D . n 
D 1 180 GLU 180 180 ?   ?   ?   D . n 
D 1 181 PRO 181 181 ?   ?   ?   D . n 
D 1 182 GLN 182 182 ?   ?   ?   D . n 
D 1 183 CYS 183 183 ?   ?   ?   D . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8UYV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8UYV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8UYV 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8UYV 
_struct.title                        'HBV T=4 3A mutant capsid from HEK-293T cells' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8UYV 
_struct_keywords.text            'HBV, Hepatitis B, Capsid, Core Protein, HEK-293T, VIRUS' 
_struct_keywords.pdbx_keywords   VIRUS 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q89656_HBV 
_struct_ref.pdbx_db_accession          Q89656 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGVNLEDPA
SRDLVVSYVNTNMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRT
PSPRRRRSQSPRRRRSQSRESQC
;
_struct_ref.pdbx_align_begin           30 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8UYV A 1 ? 183 ? Q89656 30 ? 212 ? 1 183 
2 1 8UYV B 1 ? 183 ? Q89656 30 ? 212 ? 1 183 
3 1 8UYV C 1 ? 183 ? Q89656 30 ? 212 ? 1 183 
4 1 8UYV D 1 ? 183 ? Q89656 30 ? 212 ? 1 183 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8UYV ALA A 155 ? UNP Q89656 SER 184 'engineered mutation' 155 1  
1 8UYV ALA A 162 ? UNP Q89656 SER 191 'engineered mutation' 162 2  
1 8UYV ALA A 170 ? UNP Q89656 SER 199 'engineered mutation' 170 3  
1 8UYV PRO A 181 ? UNP Q89656 SER 210 conflict              181 4  
2 8UYV ALA B 155 ? UNP Q89656 SER 184 'engineered mutation' 155 5  
2 8UYV ALA B 162 ? UNP Q89656 SER 191 'engineered mutation' 162 6  
2 8UYV ALA B 170 ? UNP Q89656 SER 199 'engineered mutation' 170 7  
2 8UYV PRO B 181 ? UNP Q89656 SER 210 conflict              181 8  
3 8UYV ALA C 155 ? UNP Q89656 SER 184 'engineered mutation' 155 9  
3 8UYV ALA C 162 ? UNP Q89656 SER 191 'engineered mutation' 162 10 
3 8UYV ALA C 170 ? UNP Q89656 SER 199 'engineered mutation' 170 11 
3 8UYV PRO C 181 ? UNP Q89656 SER 210 conflict              181 12 
4 8UYV ALA D 155 ? UNP Q89656 SER 184 'engineered mutation' 155 13 
4 8UYV ALA D 162 ? UNP Q89656 SER 191 'engineered mutation' 162 14 
4 8UYV ALA D 170 ? UNP Q89656 SER 199 'engineered mutation' 170 15 
4 8UYV PRO D 181 ? UNP Q89656 SER 210 conflict              181 16 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 'complete icosahedral assembly'                ? 240-meric   240 
2 'icosahedral asymmetric unit'                  ? tetrameric  4   
3 'icosahedral pentamer'                         ? eicosameric 20  
4 'icosahedral 23 hexamer'                       ? 24-meric    24  
5 'icosahedral asymmetric unit, std point frame' ? tetrameric  4   
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 '(1-60)'           A,B,C,D 
2 1                  A,B,C,D 
3 '(1-5)'            A,B,C,D 
4 '(1,2,6,10,23,24)' A,B,C,D 
5 P                  A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
P  'transform to point frame' ?     ?     0.00000000  1.00000000  0.00000000  0.00000 -1.00000000 0.00000000  0.00000000  0.00000 
0.00000000  0.00000000  1.00000000  0.00000 
1  'identity operation'       1_555 x,y,z 1.00000000  0.00000000  0.00000000  0.00000 0.00000000  1.00000000  0.00000000  0.00000 
0.00000000  0.00000000  1.00000000  0.00000 
2  'point symmetry operation' ?     ?     0.50000000  -0.80901699 -0.30901699 0.00000 0.80901699  0.30901699  0.50000000  0.00000 
-0.30901699 -0.50000000 0.80901699  0.00000 
3  'point symmetry operation' ?     ?     -0.30901699 -0.50000000 -0.80901699 0.00000 0.50000000  -0.80901699 0.30901699  0.00000 
-0.80901699 -0.30901699 0.50000000  0.00000 
4  'point symmetry operation' ?     ?     -0.30901699 0.50000000  -0.80901699 0.00000 -0.50000000 -0.80901699 -0.30901699 0.00000 
-0.80901699 0.30901699  0.50000000  0.00000 
5  'point symmetry operation' ?     ?     0.50000000  0.80901699  -0.30901699 0.00000 -0.80901699 0.30901699  -0.50000000 0.00000 
-0.30901699 0.50000000  0.80901699  0.00000 
6  'point symmetry operation' ?     ?     -1.00000000 0.00000000  0.00000000  0.00000 0.00000000  -1.00000000 0.00000000  0.00000 
0.00000000  0.00000000  1.00000000  0.00000 
7  'point symmetry operation' ?     ?     -0.50000000 0.80901699  0.30901699  0.00000 -0.80901699 -0.30901699 -0.50000000 0.00000 
-0.30901699 -0.50000000 0.80901699  0.00000 
8  'point symmetry operation' ?     ?     0.30901699  0.50000000  0.80901699  0.00000 -0.50000000 0.80901699  -0.30901699 0.00000 
-0.80901699 -0.30901699 0.50000000  0.00000 
9  'point symmetry operation' ?     ?     0.30901699  -0.50000000 0.80901699  0.00000 0.50000000  0.80901699  0.30901699  0.00000 
-0.80901699 0.30901699  0.50000000  0.00000 
10 'point symmetry operation' ?     ?     -0.50000000 -0.80901699 0.30901699  0.00000 0.80901699  -0.30901699 0.50000000  0.00000 
-0.30901699 0.50000000  0.80901699  0.00000 
11 'point symmetry operation' ?     ?     1.00000000  0.00000000  0.00000000  0.00000 0.00000000  -1.00000000 0.00000000  0.00000 
0.00000000  0.00000000  -1.00000000 0.00000 
12 'point symmetry operation' ?     ?     0.50000000  -0.80901699 -0.30901699 0.00000 -0.80901699 -0.30901699 -0.50000000 0.00000 
0.30901699  0.50000000  -0.80901699 0.00000 
13 'point symmetry operation' ?     ?     -0.30901699 -0.50000000 -0.80901699 0.00000 -0.50000000 0.80901699  -0.30901699 0.00000 
0.80901699  0.30901699  -0.50000000 0.00000 
14 'point symmetry operation' ?     ?     -0.30901699 0.50000000  -0.80901699 0.00000 0.50000000  0.80901699  0.30901699  0.00000 
0.80901699  -0.30901699 -0.50000000 0.00000 
15 'point symmetry operation' ?     ?     0.50000000  0.80901699  -0.30901699 0.00000 0.80901699  -0.30901699 0.50000000  0.00000 
0.30901699  -0.50000000 -0.80901699 0.00000 
16 'point symmetry operation' ?     ?     -1.00000000 0.00000000  0.00000000  0.00000 0.00000000  1.00000000  0.00000000  0.00000 
0.00000000  0.00000000  -1.00000000 0.00000 
17 'point symmetry operation' ?     ?     -0.50000000 0.80901699  0.30901699  0.00000 0.80901699  0.30901699  0.50000000  0.00000 
0.30901699  0.50000000  -0.80901699 0.00000 
18 'point symmetry operation' ?     ?     0.30901699  0.50000000  0.80901699  0.00000 0.50000000  -0.80901699 0.30901699  0.00000 
0.80901699  0.30901699  -0.50000000 0.00000 
19 'point symmetry operation' ?     ?     0.30901699  -0.50000000 0.80901699  0.00000 -0.50000000 -0.80901699 -0.30901699 0.00000 
0.80901699  -0.30901699 -0.50000000 0.00000 
20 'point symmetry operation' ?     ?     -0.50000000 -0.80901699 0.30901699  0.00000 -0.80901699 0.30901699  -0.50000000 0.00000 
0.30901699  -0.50000000 -0.80901699 0.00000 
21 'point symmetry operation' ?     ?     0.00000000  -1.00000000 0.00000000  0.00000 0.00000000  0.00000000  1.00000000  0.00000 
-1.00000000 0.00000000  0.00000000  0.00000 
22 'point symmetry operation' ?     ?     -0.80901699 -0.30901699 -0.50000000 0.00000 -0.30901699 -0.50000000 0.80901699  0.00000 
-0.50000000 0.80901699  0.30901699  0.00000 
23 'point symmetry operation' ?     ?     -0.50000000 0.80901699  -0.30901699 0.00000 -0.80901699 -0.30901699 0.50000000  0.00000 
0.30901699  0.50000000  0.80901699  0.00000 
24 'point symmetry operation' ?     ?     0.50000000  0.80901699  0.30901699  0.00000 -0.80901699 0.30901699  0.50000000  0.00000 
0.30901699  -0.50000000 0.80901699  0.00000 
25 'point symmetry operation' ?     ?     0.80901699  -0.30901699 0.50000000  0.00000 -0.30901699 0.50000000  0.80901699  0.00000 
-0.50000000 -0.80901699 0.30901699  0.00000 
26 'point symmetry operation' ?     ?     0.00000000  1.00000000  0.00000000  0.00000 0.00000000  0.00000000  1.00000000  0.00000 
1.00000000  0.00000000  0.00000000  0.00000 
27 'point symmetry operation' ?     ?     0.80901699  0.30901699  0.50000000  0.00000 -0.30901699 -0.50000000 0.80901699  0.00000 
0.50000000  -0.80901699 -0.30901699 0.00000 
28 'point symmetry operation' ?     ?     0.50000000  -0.80901699 0.30901699  0.00000 -0.80901699 -0.30901699 0.50000000  0.00000 
-0.30901699 -0.50000000 -0.80901699 0.00000 
29 'point symmetry operation' ?     ?     -0.50000000 -0.80901699 -0.30901699 0.00000 -0.80901699 0.30901699  0.50000000  0.00000 
-0.30901699 0.50000000  -0.80901699 0.00000 
30 'point symmetry operation' ?     ?     -0.80901699 0.30901699  -0.50000000 0.00000 -0.30901699 0.50000000  0.80901699  0.00000 
0.50000000  0.80901699  -0.30901699 0.00000 
31 'point symmetry operation' ?     ?     0.00000000  1.00000000  0.00000000  0.00000 0.00000000  0.00000000  -1.00000000 0.00000 
-1.00000000 0.00000000  0.00000000  0.00000 
32 'point symmetry operation' ?     ?     0.80901699  0.30901699  0.50000000  0.00000 0.30901699  0.50000000  -0.80901699 0.00000 
-0.50000000 0.80901699  0.30901699  0.00000 
33 'point symmetry operation' ?     ?     0.50000000  -0.80901699 0.30901699  0.00000 0.80901699  0.30901699  -0.50000000 0.00000 
0.30901699  0.50000000  0.80901699  0.00000 
34 'point symmetry operation' ?     ?     -0.50000000 -0.80901699 -0.30901699 0.00000 0.80901699  -0.30901699 -0.50000000 0.00000 
0.30901699  -0.50000000 0.80901699  0.00000 
35 'point symmetry operation' ?     ?     -0.80901699 0.30901699  -0.50000000 0.00000 0.30901699  -0.50000000 -0.80901699 0.00000 
-0.50000000 -0.80901699 0.30901699  0.00000 
36 'point symmetry operation' ?     ?     0.00000000  -1.00000000 0.00000000  0.00000 0.00000000  0.00000000  -1.00000000 0.00000 
1.00000000  0.00000000  0.00000000  0.00000 
37 'point symmetry operation' ?     ?     -0.80901699 -0.30901699 -0.50000000 0.00000 0.30901699  0.50000000  -0.80901699 0.00000 
0.50000000  -0.80901699 -0.30901699 0.00000 
38 'point symmetry operation' ?     ?     -0.50000000 0.80901699  -0.30901699 0.00000 0.80901699  0.30901699  -0.50000000 0.00000 
-0.30901699 -0.50000000 -0.80901699 0.00000 
39 'point symmetry operation' ?     ?     0.50000000  0.80901699  0.30901699  0.00000 0.80901699  -0.30901699 -0.50000000 0.00000 
-0.30901699 0.50000000  -0.80901699 0.00000 
40 'point symmetry operation' ?     ?     0.80901699  -0.30901699 0.50000000  0.00000 0.30901699  -0.50000000 -0.80901699 0.00000 
0.50000000  0.80901699  -0.30901699 0.00000 
41 'point symmetry operation' ?     ?     0.00000000  0.00000000  -1.00000000 0.00000 -1.00000000 0.00000000  0.00000000  0.00000 
0.00000000  1.00000000  0.00000000  0.00000 
42 'point symmetry operation' ?     ?     0.30901699  0.50000000  -0.80901699 0.00000 -0.50000000 0.80901699  0.30901699  0.00000 
0.80901699  0.30901699  0.50000000  0.00000 
43 'point symmetry operation' ?     ?     0.80901699  0.30901699  -0.50000000 0.00000 0.30901699  0.50000000  0.80901699  0.00000 
0.50000000  -0.80901699 0.30901699  0.00000 
44 'point symmetry operation' ?     ?     0.80901699  -0.30901699 -0.50000000 0.00000 0.30901699  -0.50000000 0.80901699  0.00000 
-0.50000000 -0.80901699 -0.30901699 0.00000 
45 'point symmetry operation' ?     ?     0.30901699  -0.50000000 -0.80901699 0.00000 -0.50000000 -0.80901699 0.30901699  0.00000 
-0.80901699 0.30901699  -0.50000000 0.00000 
46 'point symmetry operation' ?     ?     0.00000000  0.00000000  -1.00000000 0.00000 1.00000000  0.00000000  0.00000000  0.00000 
0.00000000  -1.00000000 0.00000000  0.00000 
47 'point symmetry operation' ?     ?     0.30901699  0.50000000  -0.80901699 0.00000 0.50000000  -0.80901699 -0.30901699 0.00000 
-0.80901699 -0.30901699 -0.50000000 0.00000 
48 'point symmetry operation' ?     ?     0.80901699  0.30901699  -0.50000000 0.00000 -0.30901699 -0.50000000 -0.80901699 0.00000 
-0.50000000 0.80901699  -0.30901699 0.00000 
49 'point symmetry operation' ?     ?     0.80901699  -0.30901699 -0.50000000 0.00000 -0.30901699 0.50000000  -0.80901699 0.00000 
0.50000000  0.80901699  0.30901699  0.00000 
50 'point symmetry operation' ?     ?     0.30901699  -0.50000000 -0.80901699 0.00000 0.50000000  0.80901699  -0.30901699 0.00000 
0.80901699  -0.30901699 0.50000000  0.00000 
51 'point symmetry operation' ?     ?     0.00000000  0.00000000  1.00000000  0.00000 -1.00000000 0.00000000  0.00000000  0.00000 
0.00000000  -1.00000000 0.00000000  0.00000 
52 'point symmetry operation' ?     ?     -0.30901699 -0.50000000 0.80901699  0.00000 -0.50000000 0.80901699  0.30901699  0.00000 
-0.80901699 -0.30901699 -0.50000000 0.00000 
53 'point symmetry operation' ?     ?     -0.80901699 -0.30901699 0.50000000  0.00000 0.30901699  0.50000000  0.80901699  0.00000 
-0.50000000 0.80901699  -0.30901699 0.00000 
54 'point symmetry operation' ?     ?     -0.80901699 0.30901699  0.50000000  0.00000 0.30901699  -0.50000000 0.80901699  0.00000 
0.50000000  0.80901699  0.30901699  0.00000 
55 'point symmetry operation' ?     ?     -0.30901699 0.50000000  0.80901699  0.00000 -0.50000000 -0.80901699 0.30901699  0.00000 
0.80901699  -0.30901699 0.50000000  0.00000 
56 'point symmetry operation' ?     ?     0.00000000  0.00000000  1.00000000  0.00000 1.00000000  0.00000000  0.00000000  0.00000 
0.00000000  1.00000000  0.00000000  0.00000 
57 'point symmetry operation' ?     ?     -0.30901699 -0.50000000 0.80901699  0.00000 0.50000000  -0.80901699 -0.30901699 0.00000 
0.80901699  0.30901699  0.50000000  0.00000 
58 'point symmetry operation' ?     ?     -0.80901699 -0.30901699 0.50000000  0.00000 -0.30901699 -0.50000000 -0.80901699 0.00000 
0.50000000  -0.80901699 0.30901699  0.00000 
59 'point symmetry operation' ?     ?     -0.80901699 0.30901699  0.50000000  0.00000 -0.30901699 0.50000000  -0.80901699 0.00000 
-0.50000000 -0.80901699 -0.30901699 0.00000 
60 'point symmetry operation' ?     ?     -0.30901699 0.50000000  0.80901699  0.00000 0.50000000  0.80901699  -0.30901699 0.00000 
-0.80901699 0.30901699  -0.50000000 0.00000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 TYR A 6   ? GLY A 10  ? TYR A 6   GLY A 10  5 ? 5  
HELX_P HELX_P2  AA2 THR A 12  ? SER A 17  ? THR A 12  SER A 17  1 ? 6  
HELX_P HELX_P3  AA3 SER A 26  ? ARG A 39  ? SER A 26  ARG A 39  1 ? 14 
HELX_P HELX_P4  AA4 GLU A 40  ? SER A 44  ? GLU A 40  SER A 44  5 ? 5  
HELX_P HELX_P5  AA5 SER A 49  ? LEU A 76  ? SER A 49  LEU A 76  1 ? 28 
HELX_P HELX_P6  AA6 ASP A 78  ? GLY A 111 ? ASP A 78  GLY A 111 1 ? 34 
HELX_P HELX_P7  AA7 GLY A 111 ? THR A 128 ? GLY A 111 THR A 128 1 ? 18 
HELX_P HELX_P8  AA8 TYR B 6   ? GLY B 10  ? TYR B 6   GLY B 10  5 ? 5  
HELX_P HELX_P9  AA9 THR B 12  ? SER B 17  ? THR B 12  SER B 17  1 ? 6  
HELX_P HELX_P10 AB1 SER B 26  ? SER B 44  ? SER B 26  SER B 44  1 ? 19 
HELX_P HELX_P11 AB2 SER B 49  ? LEU B 76  ? SER B 49  LEU B 76  1 ? 28 
HELX_P HELX_P12 AB3 ASP B 78  ? GLY B 111 ? ASP B 78  GLY B 111 1 ? 34 
HELX_P HELX_P13 AB4 GLY B 111 ? THR B 128 ? GLY B 111 THR B 128 1 ? 18 
HELX_P HELX_P14 AB5 THR C 12  ? SER C 17  ? THR C 12  SER C 17  1 ? 6  
HELX_P HELX_P15 AB6 PRO C 20  ? PHE C 24  ? PRO C 20  PHE C 24  5 ? 5  
HELX_P HELX_P16 AB7 SER C 26  ? SER C 44  ? SER C 26  SER C 44  1 ? 19 
HELX_P HELX_P17 AB8 SER C 49  ? LEU C 76  ? SER C 49  LEU C 76  1 ? 28 
HELX_P HELX_P18 AB9 ASP C 78  ? GLY C 111 ? ASP C 78  GLY C 111 1 ? 34 
HELX_P HELX_P19 AC1 GLY C 111 ? THR C 128 ? GLY C 111 THR C 128 1 ? 18 
HELX_P HELX_P20 AC2 PRO C 129 ? ARG C 133 ? PRO C 129 ARG C 133 5 ? 5  
HELX_P HELX_P21 AC3 TYR D 6   ? GLY D 10  ? TYR D 6   GLY D 10  5 ? 5  
HELX_P HELX_P22 AC4 THR D 12  ? PHE D 18  ? THR D 12  PHE D 18  1 ? 7  
HELX_P HELX_P23 AC5 SER D 26  ? SER D 44  ? SER D 26  SER D 44  1 ? 19 
HELX_P HELX_P24 AC6 SER D 49  ? LEU D 76  ? SER D 49  LEU D 76  1 ? 28 
HELX_P HELX_P25 AC7 ASP D 78  ? GLY D 111 ? ASP D 78  GLY D 111 1 ? 34 
HELX_P HELX_P26 AC8 GLY D 111 ? THR D 128 ? GLY D 111 THR D 128 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   2 
_struct_sheet.details          ? 
# 
_struct_sheet_order.sheet_id     AA1 
_struct_sheet_order.range_id_1   1 
_struct_sheet_order.range_id_2   2 
_struct_sheet_order.offset       ? 
_struct_sheet_order.sense        parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR B 147 ? VAL B 148 ? THR B 147 VAL B 148 
AA1 2 ILE C 139 ? LEU C 140 ? ILE C 139 LEU C 140 
# 
_pdbx_struct_sheet_hbond.sheet_id                AA1 
_pdbx_struct_sheet_hbond.range_id_1              1 
_pdbx_struct_sheet_hbond.range_id_2              2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id   N 
_pdbx_struct_sheet_hbond.range_1_label_comp_id   VAL 
_pdbx_struct_sheet_hbond.range_1_label_asym_id   B 
_pdbx_struct_sheet_hbond.range_1_label_seq_id    148 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id    N 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id    VAL 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id    B 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id     148 
_pdbx_struct_sheet_hbond.range_2_label_atom_id   O 
_pdbx_struct_sheet_hbond.range_2_label_comp_id   ILE 
_pdbx_struct_sheet_hbond.range_2_label_asym_id   C 
_pdbx_struct_sheet_hbond.range_2_label_seq_id    139 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id    O 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id    ILE 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id    C 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id     139 
# 
_pdbx_entry_details.entry_id                   8UYV 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O C ALA 41 ? ? OG C SER 44 ? ? 2.18 
2 1 O A GLU 14 ? ? OG A SER 17 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 45  ? ? -86.06 39.49  
2 1 PRO B 25  ? ? -58.12 172.65 
3 1 THR B 146 ? ? 43.08  28.73  
4 1 ARG B 150 ? ? -37.08 126.30 
5 1 PRO D 45  ? ? -77.56 29.19  
# 
_pdbx_point_symmetry.entry_id             8UYV 
_pdbx_point_symmetry.Schoenflies_symbol   I 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8UYV 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'FLEXIBLE FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1QGT 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1QGT 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    8UYV 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.9 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               33677 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '30mM NaCl, 50mM Tris-HCl(pH7.5), 2mM DTT' 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 VIRUS 
_em_entity_assembly.name                 'Hepatitis B virus' 
_em_entity_assembly.details              
;Recombinant HBV capsid protein was expressed by transfecting HEK-293T cells with a plasmid containing a mutant HBV capsid protein gene.
;
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8UYV 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             500 
_em_imaging.nominal_defocus_max             4500 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           6400 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             BASIC 
_em_imaging.c2_aperture_diameter            50 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.specimen_id      1 
_em_sample_support.method           ? 
_em_sample_support.film_material    ? 
_em_sample_support.grid_material    ? 
_em_sample_support.grid_mesh_size   ? 
_em_sample_support.grid_type        ? 
_em_sample_support.details          ? 
# 
_em_virus_entity.id                    1 
_em_virus_entity.virus_host_category   ? 
_em_virus_entity.virus_type            'VIRUS-LIKE PARTICLE' 
_em_virus_entity.virus_isolate         OTHER 
_em_virus_entity.entity_assembly_id    1 
_em_virus_entity.enveloped             NO 
_em_virus_entity.empty                 YES 
_em_virus_entity.details               ? 
# 
_em_vitrification.entry_id              8UYV 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8UYV 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              8UYV 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLU 145 ? A GLU 145 
2   1 Y 1 A THR 146 ? A THR 146 
3   1 Y 1 A THR 147 ? A THR 147 
4   1 Y 1 A VAL 148 ? A VAL 148 
5   1 Y 1 A VAL 149 ? A VAL 149 
6   1 Y 1 A ARG 150 ? A ARG 150 
7   1 Y 1 A ARG 151 ? A ARG 151 
8   1 Y 1 A ARG 152 ? A ARG 152 
9   1 Y 1 A GLY 153 ? A GLY 153 
10  1 Y 1 A ARG 154 ? A ARG 154 
11  1 Y 1 A ALA 155 ? A ALA 155 
12  1 Y 1 A PRO 156 ? A PRO 156 
13  1 Y 1 A ARG 157 ? A ARG 157 
14  1 Y 1 A ARG 158 ? A ARG 158 
15  1 Y 1 A ARG 159 ? A ARG 159 
16  1 Y 1 A THR 160 ? A THR 160 
17  1 Y 1 A PRO 161 ? A PRO 161 
18  1 Y 1 A ALA 162 ? A ALA 162 
19  1 Y 1 A PRO 163 ? A PRO 163 
20  1 Y 1 A ARG 164 ? A ARG 164 
21  1 Y 1 A ARG 165 ? A ARG 165 
22  1 Y 1 A ARG 166 ? A ARG 166 
23  1 Y 1 A ARG 167 ? A ARG 167 
24  1 Y 1 A SER 168 ? A SER 168 
25  1 Y 1 A GLN 169 ? A GLN 169 
26  1 Y 1 A ALA 170 ? A ALA 170 
27  1 Y 1 A PRO 171 ? A PRO 171 
28  1 Y 1 A ARG 172 ? A ARG 172 
29  1 Y 1 A ARG 173 ? A ARG 173 
30  1 Y 1 A ARG 174 ? A ARG 174 
31  1 Y 1 A ARG 175 ? A ARG 175 
32  1 Y 1 A SER 176 ? A SER 176 
33  1 Y 1 A GLN 177 ? A GLN 177 
34  1 Y 1 A SER 178 ? A SER 178 
35  1 Y 1 A ARG 179 ? A ARG 179 
36  1 Y 1 A GLU 180 ? A GLU 180 
37  1 Y 1 A PRO 181 ? A PRO 181 
38  1 Y 1 A GLN 182 ? A GLN 182 
39  1 Y 1 A CYS 183 ? A CYS 183 
40  1 Y 1 B GLY 153 ? B GLY 153 
41  1 Y 1 B ARG 154 ? B ARG 154 
42  1 Y 1 B ALA 155 ? B ALA 155 
43  1 Y 1 B PRO 156 ? B PRO 156 
44  1 Y 1 B ARG 157 ? B ARG 157 
45  1 Y 1 B ARG 158 ? B ARG 158 
46  1 Y 1 B ARG 159 ? B ARG 159 
47  1 Y 1 B THR 160 ? B THR 160 
48  1 Y 1 B PRO 161 ? B PRO 161 
49  1 Y 1 B ALA 162 ? B ALA 162 
50  1 Y 1 B PRO 163 ? B PRO 163 
51  1 Y 1 B ARG 164 ? B ARG 164 
52  1 Y 1 B ARG 165 ? B ARG 165 
53  1 Y 1 B ARG 166 ? B ARG 166 
54  1 Y 1 B ARG 167 ? B ARG 167 
55  1 Y 1 B SER 168 ? B SER 168 
56  1 Y 1 B GLN 169 ? B GLN 169 
57  1 Y 1 B ALA 170 ? B ALA 170 
58  1 Y 1 B PRO 171 ? B PRO 171 
59  1 Y 1 B ARG 172 ? B ARG 172 
60  1 Y 1 B ARG 173 ? B ARG 173 
61  1 Y 1 B ARG 174 ? B ARG 174 
62  1 Y 1 B ARG 175 ? B ARG 175 
63  1 Y 1 B SER 176 ? B SER 176 
64  1 Y 1 B GLN 177 ? B GLN 177 
65  1 Y 1 B SER 178 ? B SER 178 
66  1 Y 1 B ARG 179 ? B ARG 179 
67  1 Y 1 B GLU 180 ? B GLU 180 
68  1 Y 1 B PRO 181 ? B PRO 181 
69  1 Y 1 B GLN 182 ? B GLN 182 
70  1 Y 1 B CYS 183 ? B CYS 183 
71  1 Y 1 C THR 147 ? C THR 147 
72  1 Y 1 C VAL 148 ? C VAL 148 
73  1 Y 1 C VAL 149 ? C VAL 149 
74  1 Y 1 C ARG 150 ? C ARG 150 
75  1 Y 1 C ARG 151 ? C ARG 151 
76  1 Y 1 C ARG 152 ? C ARG 152 
77  1 Y 1 C GLY 153 ? C GLY 153 
78  1 Y 1 C ARG 154 ? C ARG 154 
79  1 Y 1 C ALA 155 ? C ALA 155 
80  1 Y 1 C PRO 156 ? C PRO 156 
81  1 Y 1 C ARG 157 ? C ARG 157 
82  1 Y 1 C ARG 158 ? C ARG 158 
83  1 Y 1 C ARG 159 ? C ARG 159 
84  1 Y 1 C THR 160 ? C THR 160 
85  1 Y 1 C PRO 161 ? C PRO 161 
86  1 Y 1 C ALA 162 ? C ALA 162 
87  1 Y 1 C PRO 163 ? C PRO 163 
88  1 Y 1 C ARG 164 ? C ARG 164 
89  1 Y 1 C ARG 165 ? C ARG 165 
90  1 Y 1 C ARG 166 ? C ARG 166 
91  1 Y 1 C ARG 167 ? C ARG 167 
92  1 Y 1 C SER 168 ? C SER 168 
93  1 Y 1 C GLN 169 ? C GLN 169 
94  1 Y 1 C ALA 170 ? C ALA 170 
95  1 Y 1 C PRO 171 ? C PRO 171 
96  1 Y 1 C ARG 172 ? C ARG 172 
97  1 Y 1 C ARG 173 ? C ARG 173 
98  1 Y 1 C ARG 174 ? C ARG 174 
99  1 Y 1 C ARG 175 ? C ARG 175 
100 1 Y 1 C SER 176 ? C SER 176 
101 1 Y 1 C GLN 177 ? C GLN 177 
102 1 Y 1 C SER 178 ? C SER 178 
103 1 Y 1 C ARG 179 ? C ARG 179 
104 1 Y 1 C GLU 180 ? C GLU 180 
105 1 Y 1 C PRO 181 ? C PRO 181 
106 1 Y 1 C GLN 182 ? C GLN 182 
107 1 Y 1 C CYS 183 ? C CYS 183 
108 1 Y 1 D GLY 153 ? D GLY 153 
109 1 Y 1 D ARG 154 ? D ARG 154 
110 1 Y 1 D ALA 155 ? D ALA 155 
111 1 Y 1 D PRO 156 ? D PRO 156 
112 1 Y 1 D ARG 157 ? D ARG 157 
113 1 Y 1 D ARG 158 ? D ARG 158 
114 1 Y 1 D ARG 159 ? D ARG 159 
115 1 Y 1 D THR 160 ? D THR 160 
116 1 Y 1 D PRO 161 ? D PRO 161 
117 1 Y 1 D ALA 162 ? D ALA 162 
118 1 Y 1 D PRO 163 ? D PRO 163 
119 1 Y 1 D ARG 164 ? D ARG 164 
120 1 Y 1 D ARG 165 ? D ARG 165 
121 1 Y 1 D ARG 166 ? D ARG 166 
122 1 Y 1 D ARG 167 ? D ARG 167 
123 1 Y 1 D SER 168 ? D SER 168 
124 1 Y 1 D GLN 169 ? D GLN 169 
125 1 Y 1 D ALA 170 ? D ALA 170 
126 1 Y 1 D PRO 171 ? D PRO 171 
127 1 Y 1 D ARG 172 ? D ARG 172 
128 1 Y 1 D ARG 173 ? D ARG 173 
129 1 Y 1 D ARG 174 ? D ARG 174 
130 1 Y 1 D ARG 175 ? D ARG 175 
131 1 Y 1 D SER 176 ? D SER 176 
132 1 Y 1 D GLN 177 ? D GLN 177 
133 1 Y 1 D SER 178 ? D SER 178 
134 1 Y 1 D ARG 179 ? D ARG 179 
135 1 Y 1 D GLU 180 ? D GLU 180 
136 1 Y 1 D PRO 181 ? D PRO 181 
137 1 Y 1 D GLN 182 ? D GLN 182 
138 1 Y 1 D CYS 183 ? D CYS 183 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-11-14 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8UYV 
_em_admin.last_update        2024-11-20 
_em_admin.map_release_date   2024-11-20 
_em_admin.title              'HBV T=4 3A mutant capsid from HEK-293T cells' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                5 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          10407 
_em_entity_assembly_naturalsource.organism             'Hepatitis B virus' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 HEK-293T 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         30 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? RELION          3.1 
'IMAGE ACQUISITION'        ? 2  ? ? 1 EPU             ?   
MASKING                    ? 3  ? ? ? ?               ?   
'CTF CORRECTION'           ? 4  1 ? ? CTFFIND         4   
'LAYERLINE INDEXING'       ? 5  ? ? ? ?               ?   
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?               ?   
'MODEL FITTING'            ? 7  ? 1 ? 'UCSF ChimeraX' ?   
OTHER                      ? 8  ? ? ? ?               ?   
'MODEL REFINEMENT'         ? 9  ? 1 ? ISOLDE          ?   
'MODEL REFINEMENT'         ? 10 ? 1 ? PHENIX          ?   
'MODEL REFINEMENT'         ? 11 ? 1 ? Coot            ?   
'INITIAL EULER ASSIGNMENT' ? 12 1 ? ? RELION          3.1 
'FINAL EULER ASSIGNMENT'   ? 13 1 ? ? RELION          3.1 
CLASSIFICATION             ? 14 1 ? ? ?               ?   
RECONSTRUCTION             ? 15 1 ? ? RELION          3.1 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 'Sample was monodisperse.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_em_virus_natural_host.entity_assembly_id   1 
_em_virus_natural_host.id                   1 
_em_virus_natural_host.ncbi_tax_id          9606 
_em_virus_natural_host.organism             'Homo sapiens' 
_em_virus_natural_host.strain               ? 
# 
_em_virus_shell.diameter             340 
_em_virus_shell.entity_assembly_id   1 
_em_virus_shell.id                   1 
_em_virus_shell.name                 'capsid protein' 
_em_virus_shell.triangulation        4 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 'United States' AI173104 1 
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 'United States' AI043453 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1QGT 
# 
_atom_sites.entry_id                    8UYV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . MET A 1 1   ? -39.863 14.249  147.066 1.00 109.28 ? 1   MET A N   1 
ATOM 2    C CA  . MET A 1 1   ? -39.021 14.709  145.930 1.00 109.28 ? 1   MET A CA  1 
ATOM 3    C C   . MET A 1 1   ? -39.893 14.874  144.691 1.00 109.28 ? 1   MET A C   1 
ATOM 4    O O   . MET A 1 1   ? -39.459 14.573  143.583 1.00 109.28 ? 1   MET A O   1 
ATOM 5    C CB  . MET A 1 1   ? -37.916 13.686  145.652 1.00 109.28 ? 1   MET A CB  1 
ATOM 6    C CG  . MET A 1 1   ? -36.828 14.135  144.688 1.00 109.28 ? 1   MET A CG  1 
ATOM 7    S SD  . MET A 1 1   ? -35.577 12.857  144.466 1.00 109.28 ? 1   MET A SD  1 
ATOM 8    C CE  . MET A 1 1   ? -34.742 12.912  146.045 1.00 109.28 ? 1   MET A CE  1 
ATOM 9    N N   . ASP A 1 2   ? -41.104 15.394  144.868 1.00 115.73 ? 2   ASP A N   1 
ATOM 10   C CA  . ASP A 1 2   ? -42.050 15.544  143.764 1.00 115.73 ? 2   ASP A CA  1 
ATOM 11   C C   . ASP A 1 2   ? -42.197 14.213  143.022 1.00 115.73 ? 2   ASP A C   1 
ATOM 12   O O   . ASP A 1 2   ? -41.866 14.075  141.844 1.00 115.73 ? 2   ASP A O   1 
ATOM 13   C CB  . ASP A 1 2   ? -41.616 16.667  142.820 1.00 115.73 ? 2   ASP A CB  1 
ATOM 14   C CG  . ASP A 1 2   ? -42.622 16.922  141.714 1.00 115.73 ? 2   ASP A CG  1 
ATOM 15   O OD1 . ASP A 1 2   ? -43.667 16.240  141.689 1.00 115.73 ? 2   ASP A OD1 1 
ATOM 16   O OD2 . ASP A 1 2   ? -42.370 17.809  140.871 1.00 115.73 ? 2   ASP A OD2 1 
ATOM 17   N N   . ILE A 1 3   ? -42.707 13.225  143.753 1.00 105.79 ? 3   ILE A N   1 
ATOM 18   C CA  . ILE A 1 3   ? -42.813 11.838  143.300 1.00 105.79 ? 3   ILE A CA  1 
ATOM 19   C C   . ILE A 1 3   ? -44.285 11.454  143.281 1.00 105.79 ? 3   ILE A C   1 
ATOM 20   O O   . ILE A 1 3   ? -44.872 11.137  144.321 1.00 105.79 ? 3   ILE A O   1 
ATOM 21   C CB  . ILE A 1 3   ? -42.006 10.868  144.169 1.00 105.79 ? 3   ILE A CB  1 
ATOM 22   C CG1 . ILE A 1 3   ? -40.640 11.459  144.513 1.00 105.79 ? 3   ILE A CG1 1 
ATOM 23   C CG2 . ILE A 1 3   ? -41.888 9.510   143.483 1.00 105.79 ? 3   ILE A CG2 1 
ATOM 24   C CD1 . ILE A 1 3   ? -39.754 11.663  143.290 1.00 105.79 ? 3   ILE A CD1 1 
ATOM 25   N N   . ASP A 1 4   ? -44.884 11.496  142.094 1.00 104.39 ? 4   ASP A N   1 
ATOM 26   C CA  . ASP A 1 4   ? -46.251 11.053  141.882 1.00 104.39 ? 4   ASP A CA  1 
ATOM 27   C C   . ASP A 1 4   ? -46.217 9.738   141.121 1.00 104.39 ? 4   ASP A C   1 
ATOM 28   O O   . ASP A 1 4   ? -45.693 9.702   139.998 1.00 104.39 ? 4   ASP A O   1 
ATOM 29   C CB  . ASP A 1 4   ? -47.020 12.110  141.094 1.00 104.39 ? 4   ASP A CB  1 
ATOM 30   C CG  . ASP A 1 4   ? -47.304 13.349  141.903 1.00 104.39 ? 4   ASP A CG  1 
ATOM 31   O OD1 . ASP A 1 4   ? -47.166 13.294  143.137 1.00 104.39 ? 4   ASP A OD1 1 
ATOM 32   O OD2 . ASP A 1 4   ? -47.674 14.379  141.305 1.00 104.39 ? 4   ASP A OD2 1 
ATOM 33   N N   . PRO A 1 5   ? -46.750 8.638   141.670 1.00 98.29  ? 5   PRO A N   1 
ATOM 34   C CA  . PRO A 1 5   ? -46.581 7.337   141.002 1.00 98.29  ? 5   PRO A CA  1 
ATOM 35   C C   . PRO A 1 5   ? -47.336 7.203   139.691 1.00 98.29  ? 5   PRO A C   1 
ATOM 36   O O   . PRO A 1 5   ? -46.983 6.336   138.885 1.00 98.29  ? 5   PRO A O   1 
ATOM 37   C CB  . PRO A 1 5   ? -47.103 6.337   142.041 1.00 98.29  ? 5   PRO A CB  1 
ATOM 38   C CG  . PRO A 1 5   ? -48.035 7.119   142.892 1.00 98.29  ? 5   PRO A CG  1 
ATOM 39   C CD  . PRO A 1 5   ? -47.505 8.521   142.928 1.00 98.29  ? 5   PRO A CD  1 
ATOM 40   N N   . TYR A 1 6   ? -48.353 8.025   139.452 1.00 96.18  ? 6   TYR A N   1 
ATOM 41   C CA  . TYR A 1 6   ? -49.148 7.946   138.234 1.00 96.18  ? 6   TYR A CA  1 
ATOM 42   C C   . TYR A 1 6   ? -48.630 8.879   137.153 1.00 96.18  ? 6   TYR A C   1 
ATOM 43   O O   . TYR A 1 6   ? -49.010 8.741   135.986 1.00 96.18  ? 6   TYR A O   1 
ATOM 44   C CB  . TYR A 1 6   ? -50.601 8.305   138.550 1.00 96.18  ? 6   TYR A CB  1 
ATOM 45   C CG  . TYR A 1 6   ? -51.174 7.536   139.715 1.00 96.18  ? 6   TYR A CG  1 
ATOM 46   C CD1 . TYR A 1 6   ? -51.442 6.179   139.619 1.00 96.18  ? 6   TYR A CD1 1 
ATOM 47   C CD2 . TYR A 1 6   ? -51.444 8.173   140.916 1.00 96.18  ? 6   TYR A CD2 1 
ATOM 48   C CE1 . TYR A 1 6   ? -51.982 5.484   140.684 1.00 96.18  ? 6   TYR A CE1 1 
ATOM 49   C CE2 . TYR A 1 6   ? -51.963 7.485   141.990 1.00 96.18  ? 6   TYR A CE2 1 
ATOM 50   C CZ  . TYR A 1 6   ? -52.232 6.142   141.870 1.00 96.18  ? 6   TYR A CZ  1 
ATOM 51   O OH  . TYR A 1 6   ? -52.742 5.454   142.946 1.00 96.18  ? 6   TYR A OH  1 
ATOM 52   N N   . LYS A 1 7   ? -47.764 9.817   137.533 1.00 101.66 ? 7   LYS A N   1 
ATOM 53   C CA  . LYS A 1 7   ? -47.298 10.861  136.631 1.00 101.66 ? 7   LYS A CA  1 
ATOM 54   C C   . LYS A 1 7   ? -46.512 10.287  135.455 1.00 101.66 ? 7   LYS A C   1 
ATOM 55   O O   . LYS A 1 7   ? -46.701 10.716  134.311 1.00 101.66 ? 7   LYS A O   1 
ATOM 56   C CB  . LYS A 1 7   ? -46.502 11.862  137.471 1.00 101.66 ? 7   LYS A CB  1 
ATOM 57   C CG  . LYS A 1 7   ? -46.040 13.169  136.860 1.00 101.66 ? 7   LYS A CG  1 
ATOM 58   C CD  . LYS A 1 7   ? -44.663 13.121  136.257 1.00 101.66 ? 7   LYS A CD  1 
ATOM 59   C CE  . LYS A 1 7   ? -44.324 14.493  135.708 1.00 101.66 ? 7   LYS A CE  1 
ATOM 60   N NZ  . LYS A 1 7   ? -43.003 14.549  135.056 1.00 101.66 ? 7   LYS A NZ  1 
ATOM 61   N N   . GLU A 1 8   ? -45.694 9.261   135.707 1.00 99.15  ? 8   GLU A N   1 
ATOM 62   C CA  . GLU A 1 8   ? -44.913 8.587   134.635 1.00 99.15  ? 8   GLU A CA  1 
ATOM 63   C C   . GLU A 1 8   ? -45.877 7.856   133.697 1.00 99.15  ? 8   GLU A C   1 
ATOM 64   O O   . GLU A 1 8   ? -45.450 7.534   132.571 1.00 99.15  ? 8   GLU A O   1 
ATOM 65   C CB  . GLU A 1 8   ? -43.900 7.609   135.232 1.00 99.15  ? 8   GLU A CB  1 
ATOM 66   C CG  . GLU A 1 8   ? -44.538 6.412   135.912 1.00 99.15  ? 8   GLU A CG  1 
ATOM 67   C CD  . GLU A 1 8   ? -43.554 5.348   136.367 1.00 99.15  ? 8   GLU A CD  1 
ATOM 68   O OE1 . GLU A 1 8   ? -42.523 5.169   135.689 1.00 99.15  ? 8   GLU A OE1 1 
ATOM 69   O OE2 . GLU A 1 8   ? -43.817 4.706   137.402 1.00 99.15  ? 8   GLU A OE2 1 
ATOM 70   N N   . PHE A 1 9   ? -47.117 7.596   134.131 1.00 94.32  ? 9   PHE A N   1 
ATOM 71   C CA  . PHE A 1 9   ? -48.114 6.902   133.328 1.00 94.32  ? 9   PHE A CA  1 
ATOM 72   C C   . PHE A 1 9   ? -49.183 7.834   132.778 1.00 94.32  ? 9   PHE A C   1 
ATOM 73   O O   . PHE A 1 9   ? -50.160 7.362   132.193 1.00 94.32  ? 9   PHE A O   1 
ATOM 74   C CB  . PHE A 1 9   ? -48.767 5.776   134.134 1.00 94.32  ? 9   PHE A CB  1 
ATOM 75   C CG  . PHE A 1 9   ? -47.806 4.709   134.569 1.00 94.32  ? 9   PHE A CG  1 
ATOM 76   C CD1 . PHE A 1 9   ? -47.378 3.746   133.672 1.00 94.32  ? 9   PHE A CD1 1 
ATOM 77   C CD2 . PHE A 1 9   ? -47.335 4.660   135.868 1.00 94.32  ? 9   PHE A CD2 1 
ATOM 78   C CE1 . PHE A 1 9   ? -46.507 2.751   134.062 1.00 94.32  ? 9   PHE A CE1 1 
ATOM 79   C CE2 . PHE A 1 9   ? -46.448 3.675   136.259 1.00 94.32  ? 9   PHE A CE2 1 
ATOM 80   C CZ  . PHE A 1 9   ? -46.037 2.719   135.355 1.00 94.32  ? 9   PHE A CZ  1 
ATOM 81   N N   . GLY A 1 10  ? -49.033 9.141   132.959 1.00 96.38  ? 10  GLY A N   1 
ATOM 82   C CA  . GLY A 1 10  ? -49.904 10.092  132.307 1.00 96.38  ? 10  GLY A CA  1 
ATOM 83   C C   . GLY A 1 10  ? -51.196 10.403  133.023 1.00 96.38  ? 10  GLY A C   1 
ATOM 84   O O   . GLY A 1 10  ? -52.102 10.970  132.402 1.00 96.38  ? 10  GLY A O   1 
ATOM 85   N N   . ALA A 1 11  ? -51.322 10.050  134.298 1.00 97.23  ? 11  ALA A N   1 
ATOM 86   C CA  . ALA A 1 11  ? -52.400 10.564  135.130 1.00 97.23  ? 11  ALA A CA  1 
ATOM 87   C C   . ALA A 1 11  ? -51.795 11.343  136.298 1.00 97.23  ? 11  ALA A C   1 
ATOM 88   O O   . ALA A 1 11  ? -50.585 11.576  136.354 1.00 97.23  ? 11  ALA A O   1 
ATOM 89   C CB  . ALA A 1 11  ? -53.295 9.420   135.611 1.00 97.23  ? 11  ALA A CB  1 
ATOM 90   N N   . THR A 1 12  ? -52.649 11.752  137.236 1.00 99.63  ? 12  THR A N   1 
ATOM 91   C CA  . THR A 1 12  ? -52.203 12.410  138.455 1.00 99.63  ? 12  THR A CA  1 
ATOM 92   C C   . THR A 1 12  ? -53.072 11.980  139.628 1.00 99.63  ? 12  THR A C   1 
ATOM 93   O O   . THR A 1 12  ? -54.195 11.500  139.455 1.00 99.63  ? 12  THR A O   1 
ATOM 94   C CB  . THR A 1 12  ? -52.234 13.939  138.320 1.00 99.63  ? 12  THR A CB  1 
ATOM 95   O OG1 . THR A 1 12  ? -53.592 14.389  138.254 1.00 99.63  ? 12  THR A OG1 1 
ATOM 96   C CG2 . THR A 1 12  ? -51.490 14.386  137.068 1.00 99.63  ? 12  THR A CG2 1 
ATOM 97   N N   . VAL A 1 13  ? -52.529 12.156  140.835 1.00 100.99 ? 13  VAL A N   1 
ATOM 98   C CA  . VAL A 1 13  ? -53.328 11.990  142.049 1.00 100.99 ? 13  VAL A CA  1 
ATOM 99   C C   . VAL A 1 13  ? -54.599 12.821  141.963 1.00 100.99 ? 13  VAL A C   1 
ATOM 100  O O   . VAL A 1 13  ? -55.683 12.368  142.348 1.00 100.99 ? 13  VAL A O   1 
ATOM 101  C CB  . VAL A 1 13  ? -52.503 12.343  143.302 1.00 100.99 ? 13  VAL A CB  1 
ATOM 102  C CG1 . VAL A 1 13  ? -53.370 12.287  144.541 1.00 100.99 ? 13  VAL A CG1 1 
ATOM 103  C CG2 . VAL A 1 13  ? -51.307 11.409  143.445 1.00 100.99 ? 13  VAL A CG2 1 
ATOM 104  N N   . GLU A 1 14  ? -54.484 14.060  141.485 1.00 103.28 ? 14  GLU A N   1 
ATOM 105  C CA  . GLU A 1 14  ? -55.636 14.954  141.477 1.00 103.28 ? 14  GLU A CA  1 
ATOM 106  C C   . GLU A 1 14  ? -56.756 14.413  140.598 1.00 103.28 ? 14  GLU A C   1 
ATOM 107  O O   . GLU A 1 14  ? -57.931 14.451  140.984 1.00 103.28 ? 14  GLU A O   1 
ATOM 108  C CB  . GLU A 1 14  ? -55.212 16.339  140.990 1.00 103.28 ? 14  GLU A CB  1 
ATOM 109  C CG  . GLU A 1 14  ? -54.256 17.061  141.918 1.00 103.28 ? 14  GLU A CG  1 
ATOM 110  C CD  . GLU A 1 14  ? -53.911 18.451  141.425 1.00 103.28 ? 14  GLU A CD  1 
ATOM 111  O OE1 . GLU A 1 14  ? -54.332 18.807  140.304 1.00 103.28 ? 14  GLU A OE1 1 
ATOM 112  O OE2 . GLU A 1 14  ? -53.221 19.189  142.159 1.00 103.28 ? 14  GLU A OE2 1 
ATOM 113  N N   . LEU A 1 15  ? -56.418 13.901  139.413 1.00 95.18  ? 15  LEU A N   1 
ATOM 114  C CA  . LEU A 1 15  ? -57.427 13.266  138.572 1.00 95.18  ? 15  LEU A CA  1 
ATOM 115  C C   . LEU A 1 15  ? -58.017 12.029  139.239 1.00 95.18  ? 15  LEU A C   1 
ATOM 116  O O   . LEU A 1 15  ? -59.236 11.828  139.226 1.00 95.18  ? 15  LEU A O   1 
ATOM 117  C CB  . LEU A 1 15  ? -56.812 12.903  137.220 1.00 95.18  ? 15  LEU A CB  1 
ATOM 118  C CG  . LEU A 1 15  ? -57.698 12.130  136.242 1.00 95.18  ? 15  LEU A CG  1 
ATOM 119  C CD1 . LEU A 1 15  ? -58.915 12.949  135.852 1.00 95.18  ? 15  LEU A CD1 1 
ATOM 120  C CD2 . LEU A 1 15  ? -56.898 11.729  135.013 1.00 95.18  ? 15  LEU A CD2 1 
ATOM 121  N N   . LEU A 1 16  ? -57.166 11.191  139.833 1.00 93.11  ? 16  LEU A N   1 
ATOM 122  C CA  . LEU A 1 16  ? -57.631 9.980   140.499 1.00 93.11  ? 16  LEU A CA  1 
ATOM 123  C C   . LEU A 1 16  ? -58.492 10.265  141.725 1.00 93.11  ? 16  LEU A C   1 
ATOM 124  O O   . LEU A 1 16  ? -59.217 9.373   142.177 1.00 93.11  ? 16  LEU A O   1 
ATOM 125  C CB  . LEU A 1 16  ? -56.422 9.130   140.900 1.00 93.11  ? 16  LEU A CB  1 
ATOM 126  C CG  . LEU A 1 16  ? -56.707 7.756   141.502 1.00 93.11  ? 16  LEU A CG  1 
ATOM 127  C CD1 . LEU A 1 16  ? -57.452 6.876   140.512 1.00 93.11  ? 16  LEU A CD1 1 
ATOM 128  C CD2 . LEU A 1 16  ? -55.415 7.093   141.930 1.00 93.11  ? 16  LEU A CD2 1 
ATOM 129  N N   . SER A 1 17  ? -58.426 11.478  142.270 1.00 96.59  ? 17  SER A N   1 
ATOM 130  C CA  . SER A 1 17  ? -59.243 11.901  143.404 1.00 96.59  ? 17  SER A CA  1 
ATOM 131  C C   . SER A 1 17  ? -60.726 12.048  143.081 1.00 96.59  ? 17  SER A C   1 
ATOM 132  O O   . SER A 1 17  ? -61.500 12.340  143.998 1.00 96.59  ? 17  SER A O   1 
ATOM 133  C CB  . SER A 1 17  ? -58.709 13.227  143.949 1.00 96.59  ? 17  SER A CB  1 
ATOM 134  O OG  . SER A 1 17  ? -58.815 14.255  142.981 1.00 96.59  ? 17  SER A OG  1 
ATOM 135  N N   . PHE A 1 18  ? -61.148 11.866  141.829 1.00 93.42  ? 18  PHE A N   1 
ATOM 136  C CA  . PHE A 1 18  ? -62.579 11.853  141.535 1.00 93.42  ? 18  PHE A CA  1 
ATOM 137  C C   . PHE A 1 18  ? -63.300 10.642  142.119 1.00 93.42  ? 18  PHE A C   1 
ATOM 138  O O   . PHE A 1 18  ? -64.463 10.760  142.519 1.00 93.42  ? 18  PHE A O   1 
ATOM 139  C CB  . PHE A 1 18  ? -62.799 11.879  140.020 1.00 93.42  ? 18  PHE A CB  1 
ATOM 140  C CG  . PHE A 1 18  ? -62.378 13.165  139.352 1.00 93.42  ? 18  PHE A CG  1 
ATOM 141  C CD1 . PHE A 1 18  ? -62.076 14.297  140.090 1.00 93.42  ? 18  PHE A CD1 1 
ATOM 142  C CD2 . PHE A 1 18  ? -62.297 13.236  137.971 1.00 93.42  ? 18  PHE A CD2 1 
ATOM 143  C CE1 . PHE A 1 18  ? -61.698 15.467  139.465 1.00 93.42  ? 18  PHE A CE1 1 
ATOM 144  C CE2 . PHE A 1 18  ? -61.920 14.405  137.341 1.00 93.42  ? 18  PHE A CE2 1 
ATOM 145  C CZ  . PHE A 1 18  ? -61.619 15.520  138.089 1.00 93.42  ? 18  PHE A CZ  1 
ATOM 146  N N   . LEU A 1 19  ? -62.652 9.488   142.186 1.00 90.69  ? 19  LEU A N   1 
ATOM 147  C CA  . LEU A 1 19  ? -63.289 8.323   142.798 1.00 90.69  ? 19  LEU A CA  1 
ATOM 148  C C   . LEU A 1 19  ? -63.358 8.459   144.317 1.00 90.69  ? 19  LEU A C   1 
ATOM 149  O O   . LEU A 1 19  ? -62.345 8.775   144.951 1.00 90.69  ? 19  LEU A O   1 
ATOM 150  C CB  . LEU A 1 19  ? -62.527 7.058   142.419 1.00 90.69  ? 19  LEU A CB  1 
ATOM 151  C CG  . LEU A 1 19  ? -62.435 6.795   140.914 1.00 90.69  ? 19  LEU A CG  1 
ATOM 152  C CD1 . LEU A 1 19  ? -61.517 5.621   140.629 1.00 90.69  ? 19  LEU A CD1 1 
ATOM 153  C CD2 . LEU A 1 19  ? -63.814 6.554   140.321 1.00 90.69  ? 19  LEU A CD2 1 
ATOM 154  N N   . PRO A 1 20  ? -64.520 8.234   144.936 1.00 91.43  ? 20  PRO A N   1 
ATOM 155  C CA  . PRO A 1 20  ? -64.568 8.131   146.399 1.00 91.43  ? 20  PRO A CA  1 
ATOM 156  C C   . PRO A 1 20  ? -63.813 6.914   146.917 1.00 91.43  ? 20  PRO A C   1 
ATOM 157  O O   . PRO A 1 20  ? -63.676 5.896   146.234 1.00 91.43  ? 20  PRO A O   1 
ATOM 158  C CB  . PRO A 1 20  ? -66.068 8.030   146.700 1.00 91.43  ? 20  PRO A CB  1 
ATOM 159  C CG  . PRO A 1 20  ? -66.741 8.579   145.492 1.00 91.43  ? 20  PRO A CG  1 
ATOM 160  C CD  . PRO A 1 20  ? -65.867 8.168   144.352 1.00 91.43  ? 20  PRO A CD  1 
ATOM 161  N N   . SER A 1 21  ? -63.328 7.032   148.156 1.00 94.23  ? 21  SER A N   1 
ATOM 162  C CA  . SER A 1 21  ? -62.590 5.948   148.801 1.00 94.23  ? 21  SER A CA  1 
ATOM 163  C C   . SER A 1 21  ? -63.400 4.665   148.996 1.00 94.23  ? 21  SER A C   1 
ATOM 164  O O   . SER A 1 21  ? -62.804 3.588   149.089 1.00 94.23  ? 21  SER A O   1 
ATOM 165  C CB  . SER A 1 21  ? -62.071 6.419   150.159 1.00 94.23  ? 21  SER A CB  1 
ATOM 166  O OG  . SER A 1 21  ? -63.144 6.699   151.041 1.00 94.23  ? 21  SER A OG  1 
ATOM 167  N N   . ASP A 1 22  ? -64.732 4.743   149.062 1.00 96.97  ? 22  ASP A N   1 
ATOM 168  C CA  . ASP A 1 22  ? -65.549 3.534   149.170 1.00 96.97  ? 22  ASP A CA  1 
ATOM 169  C C   . ASP A 1 22  ? -65.603 2.736   147.875 1.00 96.97  ? 22  ASP A C   1 
ATOM 170  O O   . ASP A 1 22  ? -66.019 1.573   147.893 1.00 96.97  ? 22  ASP A O   1 
ATOM 171  C CB  . ASP A 1 22  ? -66.972 3.888   149.607 1.00 96.97  ? 22  ASP A CB  1 
ATOM 172  C CG  . ASP A 1 22  ? -67.694 4.751   148.598 1.00 96.97  ? 22  ASP A CG  1 
ATOM 173  O OD1 . ASP A 1 22  ? -67.054 5.170   147.618 1.00 96.97  ? 22  ASP A OD1 1 
ATOM 174  O OD2 . ASP A 1 22  ? -68.900 5.012   148.787 1.00 96.97  ? 22  ASP A OD2 1 
ATOM 175  N N   . PHE A 1 23  ? -65.203 3.336   146.757 1.00 89.66  ? 23  PHE A N   1 
ATOM 176  C CA  . PHE A 1 23  ? -65.357 2.690   145.457 1.00 89.66  ? 23  PHE A CA  1 
ATOM 177  C C   . PHE A 1 23  ? -64.442 1.477   145.300 1.00 89.66  ? 23  PHE A C   1 
ATOM 178  O O   . PHE A 1 23  ? -64.859 0.453   144.748 1.00 89.66  ? 23  PHE A O   1 
ATOM 179  C CB  . PHE A 1 23  ? -65.093 3.715   144.355 1.00 89.66  ? 23  PHE A CB  1 
ATOM 180  C CG  . PHE A 1 23  ? -65.015 3.126   142.979 1.00 89.66  ? 23  PHE A CG  1 
ATOM 181  C CD1 . PHE A 1 23  ? -66.163 2.837   142.266 1.00 89.66  ? 23  PHE A CD1 1 
ATOM 182  C CD2 . PHE A 1 23  ? -63.787 2.874   142.392 1.00 89.66  ? 23  PHE A CD2 1 
ATOM 183  C CE1 . PHE A 1 23  ? -66.091 2.287   141.004 1.00 89.66  ? 23  PHE A CE1 1 
ATOM 184  C CE2 . PHE A 1 23  ? -63.710 2.312   141.134 1.00 89.66  ? 23  PHE A CE2 1 
ATOM 185  C CZ  . PHE A 1 23  ? -64.862 2.017   140.440 1.00 89.66  ? 23  PHE A CZ  1 
ATOM 186  N N   . PHE A 1 24  ? -63.202 1.566   145.768 1.00 89.79  ? 24  PHE A N   1 
ATOM 187  C CA  . PHE A 1 24  ? -62.213 0.546   145.438 1.00 89.79  ? 24  PHE A CA  1 
ATOM 188  C C   . PHE A 1 24  ? -62.510 -0.778  146.149 1.00 89.79  ? 24  PHE A C   1 
ATOM 189  O O   . PHE A 1 24  ? -62.864 -0.785  147.332 1.00 89.79  ? 24  PHE A O   1 
ATOM 190  C CB  . PHE A 1 24  ? -60.824 1.048   145.814 1.00 89.79  ? 24  PHE A CB  1 
ATOM 191  C CG  . PHE A 1 24  ? -60.453 2.331   145.129 1.00 89.79  ? 24  PHE A CG  1 
ATOM 192  C CD1 . PHE A 1 24  ? -59.976 2.326   143.832 1.00 89.79  ? 24  PHE A CD1 1 
ATOM 193  C CD2 . PHE A 1 24  ? -60.575 3.540   145.787 1.00 89.79  ? 24  PHE A CD2 1 
ATOM 194  C CE1 . PHE A 1 24  ? -59.641 3.504   143.199 1.00 89.79  ? 24  PHE A CE1 1 
ATOM 195  C CE2 . PHE A 1 24  ? -60.238 4.722   145.161 1.00 89.79  ? 24  PHE A CE2 1 
ATOM 196  C CZ  . PHE A 1 24  ? -59.783 4.703   143.861 1.00 89.79  ? 24  PHE A CZ  1 
ATOM 197  N N   . PRO A 1 25  ? -62.374 -1.913  145.455 1.00 90.51  ? 25  PRO A N   1 
ATOM 198  C CA  . PRO A 1 25  ? -62.614 -3.222  146.082 1.00 90.51  ? 25  PRO A CA  1 
ATOM 199  C C   . PRO A 1 25  ? -61.628 -3.544  147.200 1.00 90.51  ? 25  PRO A C   1 
ATOM 200  O O   . PRO A 1 25  ? -60.635 -2.853  147.431 1.00 90.51  ? 25  PRO A O   1 
ATOM 201  C CB  . PRO A 1 25  ? -62.465 -4.213  144.920 1.00 90.51  ? 25  PRO A CB  1 
ATOM 202  C CG  . PRO A 1 25  ? -62.674 -3.413  143.702 1.00 90.51  ? 25  PRO A CG  1 
ATOM 203  C CD  . PRO A 1 25  ? -62.122 -2.057  144.012 1.00 90.51  ? 25  PRO A CD  1 
ATOM 204  N N   . SER A 1 26  ? -61.930 -4.637  147.901 1.00 99.20  ? 26  SER A N   1 
ATOM 205  C CA  . SER A 1 26  ? -61.053 -5.167  148.938 1.00 99.20  ? 26  SER A CA  1 
ATOM 206  C C   . SER A 1 26  ? -59.755 -5.729  148.357 1.00 99.20  ? 26  SER A C   1 
ATOM 207  O O   . SER A 1 26  ? -59.698 -6.173  147.207 1.00 99.20  ? 26  SER A O   1 
ATOM 208  C CB  . SER A 1 26  ? -61.772 -6.256  149.733 1.00 99.20  ? 26  SER A CB  1 
ATOM 209  O OG  . SER A 1 26  ? -61.669 -7.512  149.085 1.00 99.20  ? 26  SER A OG  1 
ATOM 210  N N   . VAL A 1 27  ? -58.706 -5.700  149.183 1.00 98.75  ? 27  VAL A N   1 
ATOM 211  C CA  . VAL A 1 27  ? -57.391 -6.214  148.797 1.00 98.75  ? 27  VAL A CA  1 
ATOM 212  C C   . VAL A 1 27  ? -57.454 -7.681  148.376 1.00 98.75  ? 27  VAL A C   1 
ATOM 213  O O   . VAL A 1 27  ? -56.763 -8.102  147.440 1.00 98.75  ? 27  VAL A O   1 
ATOM 214  C CB  . VAL A 1 27  ? -56.387 -6.019  149.950 1.00 98.75  ? 27  VAL A CB  1 
ATOM 215  C CG1 . VAL A 1 27  ? -56.162 -4.546  150.217 1.00 98.75  ? 27  VAL A CG1 1 
ATOM 216  C CG2 . VAL A 1 27  ? -56.858 -6.734  151.213 1.00 98.75  ? 27  VAL A CG2 1 
ATOM 217  N N   . ARG A 1 28  ? -58.270 -8.484  149.062 1.00 103.98 ? 28  ARG A N   1 
ATOM 218  C CA  . ARG A 1 28  ? -58.371 -9.904  148.731 1.00 103.98 ? 28  ARG A CA  1 
ATOM 219  C C   . ARG A 1 28  ? -58.900 -10.149 147.324 1.00 103.98 ? 28  ARG A C   1 
ATOM 220  O O   . ARG A 1 28  ? -58.371 -11.003 146.603 1.00 103.98 ? 28  ARG A O   1 
ATOM 221  C CB  . ARG A 1 28  ? -59.250 -10.606 149.765 1.00 103.98 ? 28  ARG A CB  1 
ATOM 222  C CG  . ARG A 1 28  ? -59.380 -12.111 149.570 1.00 103.98 ? 28  ARG A CG  1 
ATOM 223  C CD  . ARG A 1 28  ? -58.088 -12.853 149.879 1.00 103.98 ? 28  ARG A CD  1 
ATOM 224  N NE  . ARG A 1 28  ? -57.201 -12.891 148.722 1.00 103.98 ? 28  ARG A NE  1 
ATOM 225  C CZ  . ARG A 1 28  ? -55.993 -13.439 148.708 1.00 103.98 ? 28  ARG A CZ  1 
ATOM 226  N NH1 . ARG A 1 28  ? -55.461 -13.975 149.796 1.00 103.98 ? 28  ARG A NH1 1 
ATOM 227  N NH2 . ARG A 1 28  ? -55.293 -13.435 147.578 1.00 103.98 ? 28  ARG A NH2 1 
ATOM 228  N N   . ASP A 1 29  ? -59.933 -9.421  146.904 1.00 101.84 ? 29  ASP A N   1 
ATOM 229  C CA  . ASP A 1 29  ? -60.443 -9.619  145.551 1.00 101.84 ? 29  ASP A CA  1 
ATOM 230  C C   . ASP A 1 29  ? -59.404 -9.242  144.502 1.00 101.84 ? 29  ASP A C   1 
ATOM 231  O O   . ASP A 1 29  ? -59.244 -9.942  143.492 1.00 101.84 ? 29  ASP A O   1 
ATOM 232  C CB  . ASP A 1 29  ? -61.720 -8.803  145.350 1.00 101.84 ? 29  ASP A CB  1 
ATOM 233  C CG  . ASP A 1 29  ? -62.772 -9.106  146.395 1.00 101.84 ? 29  ASP A CG  1 
ATOM 234  O OD1 . ASP A 1 29  ? -62.658 -10.151 147.067 1.00 101.84 ? 29  ASP A OD1 1 
ATOM 235  O OD2 . ASP A 1 29  ? -63.714 -8.300  146.541 1.00 101.84 ? 29  ASP A OD2 1 
ATOM 236  N N   . LEU A 1 30  ? -58.644 -8.179  144.752 1.00 95.57  ? 30  LEU A N   1 
ATOM 237  C CA  . LEU A 1 30  ? -57.610 -7.763  143.810 1.00 95.57  ? 30  LEU A CA  1 
ATOM 238  C C   . LEU A 1 30  ? -56.478 -8.783  143.731 1.00 95.57  ? 30  LEU A C   1 
ATOM 239  O O   . LEU A 1 30  ? -56.011 -9.120  142.636 1.00 95.57  ? 30  LEU A O   1 
ATOM 240  C CB  . LEU A 1 30  ? -57.070 -6.392  144.216 1.00 95.57  ? 30  LEU A CB  1 
ATOM 241  C CG  . LEU A 1 30  ? -58.094 -5.254  144.209 1.00 95.57  ? 30  LEU A CG  1 
ATOM 242  C CD1 . LEU A 1 30  ? -57.514 -4.007  144.850 1.00 95.57  ? 30  LEU A CD1 1 
ATOM 243  C CD2 . LEU A 1 30  ? -58.565 -4.952  142.797 1.00 95.57  ? 30  LEU A CD2 1 
ATOM 244  N N   . LEU A 1 31  ? -56.007 -9.266  144.880 1.00 100.28 ? 31  LEU A N   1 
ATOM 245  C CA  . LEU A 1 31  ? -54.958 -10.282 144.876 1.00 100.28 ? 31  LEU A CA  1 
ATOM 246  C C   . LEU A 1 31  ? -55.421 -11.579 144.221 1.00 100.28 ? 31  LEU A C   1 
ATOM 247  O O   . LEU A 1 31  ? -54.662 -12.206 143.473 1.00 100.28 ? 31  LEU A O   1 
ATOM 248  C CB  . LEU A 1 31  ? -54.483 -10.549 146.304 1.00 100.28 ? 31  LEU A CB  1 
ATOM 249  C CG  . LEU A 1 31  ? -53.721 -9.410  146.986 1.00 100.28 ? 31  LEU A CG  1 
ATOM 250  C CD1 . LEU A 1 31  ? -53.456 -9.752  148.440 1.00 100.28 ? 31  LEU A CD1 1 
ATOM 251  C CD2 . LEU A 1 31  ? -52.415 -9.114  146.265 1.00 100.28 ? 31  LEU A CD2 1 
ATOM 252  N N   . ASP A 1 32  ? -56.660 -12.001 144.484 1.00 102.14 ? 32  ASP A N   1 
ATOM 253  C CA  . ASP A 1 32  ? -57.222 -13.151 143.780 1.00 102.14 ? 32  ASP A CA  1 
ATOM 254  C C   . ASP A 1 32  ? -57.230 -12.946 142.269 1.00 102.14 ? 32  ASP A C   1 
ATOM 255  O O   . ASP A 1 32  ? -56.842 -13.842 141.509 1.00 102.14 ? 32  ASP A O   1 
ATOM 256  C CB  . ASP A 1 32  ? -58.637 -13.423 144.289 1.00 102.14 ? 32  ASP A CB  1 
ATOM 257  C CG  . ASP A 1 32  ? -58.649 -14.094 145.649 1.00 102.14 ? 32  ASP A CG  1 
ATOM 258  O OD1 . ASP A 1 32  ? -57.568 -14.502 146.125 1.00 102.14 ? 32  ASP A OD1 1 
ATOM 259  O OD2 . ASP A 1 32  ? -59.740 -14.211 146.244 1.00 102.14 ? 32  ASP A OD2 1 
ATOM 260  N N   . THR A 1 33  ? -57.669 -11.773 141.812 1.00 98.97  ? 33  THR A N   1 
ATOM 261  C CA  . THR A 1 33  ? -57.689 -11.498 140.378 1.00 98.97  ? 33  THR A CA  1 
ATOM 262  C C   . THR A 1 33  ? -56.286 -11.546 139.777 1.00 98.97  ? 33  THR A C   1 
ATOM 263  O O   . THR A 1 33  ? -56.067 -12.151 138.718 1.00 98.97  ? 33  THR A O   1 
ATOM 264  C CB  . THR A 1 33  ? -58.336 -10.136 140.122 1.00 98.97  ? 33  THR A CB  1 
ATOM 265  O OG1 . THR A 1 33  ? -59.653 -10.119 140.683 1.00 98.97  ? 33  THR A OG1 1 
ATOM 266  C CG2 . THR A 1 33  ? -58.427 -9.852  138.630 1.00 98.97  ? 33  THR A CG2 1 
ATOM 267  N N   . ALA A 1 34  ? -55.322 -10.912 140.446 1.00 98.71  ? 34  ALA A N   1 
ATOM 268  C CA  . ALA A 1 34  ? -53.939 -10.942 139.973 1.00 98.71  ? 34  ALA A CA  1 
ATOM 269  C C   . ALA A 1 34  ? -53.387 -12.360 139.920 1.00 98.71  ? 34  ALA A C   1 
ATOM 270  O O   . ALA A 1 34  ? -52.731 -12.740 138.942 1.00 98.71  ? 34  ALA A O   1 
ATOM 271  C CB  . ALA A 1 34  ? -53.066 -10.068 140.872 1.00 98.71  ? 34  ALA A CB  1 
ATOM 272  N N   . SER A 1 35  ? -53.690 -13.178 140.927 1.00 103.13 ? 35  SER A N   1 
ATOM 273  C CA  . SER A 1 35  ? -53.188 -14.547 140.943 1.00 103.13 ? 35  SER A CA  1 
ATOM 274  C C   . SER A 1 35  ? -53.822 -15.375 139.835 1.00 103.13 ? 35  SER A C   1 
ATOM 275  O O   . SER A 1 35  ? -53.162 -16.230 139.235 1.00 103.13 ? 35  SER A O   1 
ATOM 276  C CB  . SER A 1 35  ? -53.454 -15.183 142.305 1.00 103.13 ? 35  SER A CB  1 
ATOM 277  O OG  . SER A 1 35  ? -53.111 -16.556 142.303 1.00 103.13 ? 35  SER A OG  1 
ATOM 278  N N   . ALA A 1 36  ? -55.097 -15.132 139.550 1.00 98.39  ? 36  ALA A N   1 
ATOM 279  C CA  . ALA A 1 36  ? -55.785 -15.888 138.510 1.00 98.39  ? 36  ALA A CA  1 
ATOM 280  C C   . ALA A 1 36  ? -55.278 -15.514 137.122 1.00 98.39  ? 36  ALA A C   1 
ATOM 281  O O   . ALA A 1 36  ? -55.122 -16.384 136.258 1.00 98.39  ? 36  ALA A O   1 
ATOM 282  C CB  . ALA A 1 36  ? -57.292 -15.658 138.608 1.00 98.39  ? 36  ALA A CB  1 
ATOM 283  N N   . LEU A 1 37  ? -55.027 -14.242 136.834 1.00 99.54  ? 37  LEU A N   1 
ATOM 284  C CA  . LEU A 1 37  ? -54.748 -13.813 135.433 1.00 99.54  ? 37  LEU A CA  1 
ATOM 285  C C   . LEU A 1 37  ? -53.269 -13.644 135.075 1.00 99.54  ? 37  LEU A C   1 
ATOM 286  O O   . LEU A 1 37  ? -52.948 -13.958 133.922 1.00 99.54  ? 37  LEU A O   1 
ATOM 287  C CB  . LEU A 1 37  ? -55.473 -12.484 135.223 1.00 99.54  ? 37  LEU A CB  1 
ATOM 288  C CG  . LEU A 1 37  ? -56.981 -12.510 135.451 1.00 99.54  ? 37  LEU A CG  1 
ATOM 289  C CD1 . LEU A 1 37  ? -57.540 -11.100 135.487 1.00 99.54  ? 37  LEU A CD1 1 
ATOM 290  C CD2 . LEU A 1 37  ? -57.676 -13.336 134.382 1.00 99.54  ? 37  LEU A CD2 1 
ATOM 291  N N   . TYR A 1 38  ? -52.399 -13.167 135.967 1.00 99.45  ? 38  TYR A N   1 
ATOM 292  C CA  . TYR A 1 38  ? -50.997 -12.828 135.598 1.00 99.45  ? 38  TYR A CA  1 
ATOM 293  C C   . TYR A 1 38  ? -49.926 -13.561 136.414 1.00 99.45  ? 38  TYR A C   1 
ATOM 294  O O   . TYR A 1 38  ? -48.750 -13.205 136.243 1.00 99.45  ? 38  TYR A O   1 
ATOM 295  C CB  . TYR A 1 38  ? -50.822 -11.319 135.756 1.00 99.45  ? 38  TYR A CB  1 
ATOM 296  C CG  . TYR A 1 38  ? -51.864 -10.502 135.039 1.00 99.45  ? 38  TYR A CG  1 
ATOM 297  C CD1 . TYR A 1 38  ? -51.649 -10.047 133.751 1.00 99.45  ? 38  TYR A CD1 1 
ATOM 298  C CD2 . TYR A 1 38  ? -53.071 -10.194 135.642 1.00 99.45  ? 38  TYR A CD2 1 
ATOM 299  C CE1 . TYR A 1 38  ? -52.603 -9.300  133.081 1.00 99.45  ? 38  TYR A CE1 1 
ATOM 300  C CE2 . TYR A 1 38  ? -54.036 -9.449  134.986 1.00 99.45  ? 38  TYR A CE2 1 
ATOM 301  C CZ  . TYR A 1 38  ? -53.801 -8.999  133.700 1.00 99.45  ? 38  TYR A CZ  1 
ATOM 302  O OH  . TYR A 1 38  ? -54.740 -8.265  133.039 1.00 99.45  ? 38  TYR A OH  1 
ATOM 303  N N   . ARG A 1 39  ? -50.271 -14.560 137.223 1.00 105.45 ? 39  ARG A N   1 
ATOM 304  C CA  . ARG A 1 39  ? -49.287 -15.244 138.106 1.00 105.45 ? 39  ARG A CA  1 
ATOM 305  C C   . ARG A 1 39  ? -48.037 -15.627 137.316 1.00 105.45 ? 39  ARG A C   1 
ATOM 306  O O   . ARG A 1 39  ? -46.937 -15.414 137.841 1.00 105.45 ? 39  ARG A O   1 
ATOM 307  C CB  . ARG A 1 39  ? -49.867 -16.517 138.719 1.00 105.45 ? 39  ARG A CB  1 
ATOM 308  C CG  . ARG A 1 39  ? -48.835 -17.363 139.450 1.00 105.45 ? 39  ARG A CG  1 
ATOM 309  C CD  . ARG A 1 39  ? -49.422 -18.625 140.046 1.00 105.45 ? 39  ARG A CD  1 
ATOM 310  N NE  . ARG A 1 39  ? -50.301 -18.340 141.168 1.00 105.45 ? 39  ARG A NE  1 
ATOM 311  C CZ  . ARG A 1 39  ? -49.889 -18.045 142.395 1.00 105.45 ? 39  ARG A CZ  1 
ATOM 312  N NH1 . ARG A 1 39  ? -48.598 -17.973 142.670 1.00 105.45 ? 39  ARG A NH1 1 
ATOM 313  N NH2 . ARG A 1 39  ? -50.774 -17.801 143.344 1.00 105.45 ? 39  ARG A NH2 1 
ATOM 314  N N   . GLU A 1 40  ? -48.184 -16.179 136.115 1.00 108.28 ? 40  GLU A N   1 
ATOM 315  C CA  . GLU A 1 40  ? -47.034 -16.669 135.313 1.00 108.28 ? 40  GLU A CA  1 
ATOM 316  C C   . GLU A 1 40  ? -46.104 -15.519 134.946 1.00 108.28 ? 40  GLU A C   1 
ATOM 317  O O   . GLU A 1 40  ? -44.892 -15.667 135.160 1.00 108.28 ? 40  GLU A O   1 
ATOM 318  C CB  . GLU A 1 40  ? -47.527 -17.331 134.032 1.00 108.28 ? 40  GLU A CB  1 
ATOM 319  C CG  . GLU A 1 40  ? -48.332 -18.592 134.265 1.00 108.28 ? 40  GLU A CG  1 
ATOM 320  C CD  . GLU A 1 40  ? -47.507 -19.796 134.683 1.00 108.28 ? 40  GLU A CD  1 
ATOM 321  O OE1 . GLU A 1 40  ? -46.301 -19.623 134.944 1.00 108.28 ? 40  GLU A OE1 1 
ATOM 322  O OE2 . GLU A 1 40  ? -48.072 -20.906 134.739 1.00 108.28 ? 40  GLU A OE2 1 
ATOM 323  N N   . ALA A 1 41  ? -46.634 -14.420 134.420 1.00 102.09 ? 41  ALA A N   1 
ATOM 324  C CA  . ALA A 1 41  ? -45.825 -13.274 133.954 1.00 102.09 ? 41  ALA A CA  1 
ATOM 325  C C   . ALA A 1 41  ? -45.160 -12.580 135.133 1.00 102.09 ? 41  ALA A C   1 
ATOM 326  O O   . ALA A 1 41  ? -43.983 -12.244 135.005 1.00 102.09 ? 41  ALA A O   1 
ATOM 327  C CB  . ALA A 1 41  ? -46.700 -12.311 133.209 1.00 102.09 ? 41  ALA A CB  1 
ATOM 328  N N   . LEU A 1 42  ? -45.877 -12.389 136.236 1.00 98.03  ? 42  LEU A N   1 
ATOM 329  C CA  . LEU A 1 42  ? -45.347 -11.639 137.399 1.00 98.03  ? 42  LEU A CA  1 
ATOM 330  C C   . LEU A 1 42  ? -44.254 -12.461 138.082 1.00 98.03  ? 42  LEU A C   1 
ATOM 331  O O   . LEU A 1 42  ? -43.674 -11.949 139.047 1.00 98.03  ? 42  LEU A O   1 
ATOM 332  C CB  . LEU A 1 42  ? -46.502 -11.326 138.354 1.00 98.03  ? 42  LEU A CB  1 
ATOM 333  C CG  . LEU A 1 42  ? -47.475 -10.254 137.871 1.00 98.03  ? 42  LEU A CG  1 
ATOM 334  C CD1 . LEU A 1 42  ? -48.637 -10.105 138.839 1.00 98.03  ? 42  LEU A CD1 1 
ATOM 335  C CD2 . LEU A 1 42  ? -46.767 -8.921  137.683 1.00 98.03  ? 42  LEU A CD2 1 
ATOM 336  N N   . GLU A 1 43  ? -43.988 -13.680 137.612 1.00 105.24 ? 43  GLU A N   1 
ATOM 337  C CA  . GLU A 1 43  ? -42.959 -14.565 138.214 1.00 105.24 ? 43  GLU A CA  1 
ATOM 338  C C   . GLU A 1 43  ? -41.930 -14.992 137.164 1.00 105.24 ? 43  GLU A C   1 
ATOM 339  O O   . GLU A 1 43  ? -40.974 -15.676 137.555 1.00 105.24 ? 43  GLU A O   1 
ATOM 340  C CB  . GLU A 1 43  ? -43.629 -15.777 138.856 1.00 105.24 ? 43  GLU A CB  1 
ATOM 341  C CG  . GLU A 1 43  ? -44.421 -15.427 140.100 1.00 105.24 ? 43  GLU A CG  1 
ATOM 342  C CD  . GLU A 1 43  ? -44.990 -16.620 140.845 1.00 105.24 ? 43  GLU A CD  1 
ATOM 343  O OE1 . GLU A 1 43  ? -44.810 -17.755 140.365 1.00 105.24 ? 43  GLU A OE1 1 
ATOM 344  O OE2 . GLU A 1 43  ? -45.610 -16.412 141.907 1.00 105.24 ? 43  GLU A OE2 1 
ATOM 345  N N   . SER A 1 44  ? -42.122 -14.593 135.901 1.00 104.08 ? 44  SER A N   1 
ATOM 346  C CA  . SER A 1 44  ? -41.202 -14.924 134.782 1.00 104.08 ? 44  SER A CA  1 
ATOM 347  C C   . SER A 1 44  ? -40.014 -13.960 134.803 1.00 104.08 ? 44  SER A C   1 
ATOM 348  O O   . SER A 1 44  ? -40.140 -12.881 135.415 1.00 104.08 ? 44  SER A O   1 
ATOM 349  C CB  . SER A 1 44  ? -41.924 -14.884 133.461 1.00 104.08 ? 44  SER A CB  1 
ATOM 350  O OG  . SER A 1 44  ? -42.405 -13.577 133.177 1.00 104.08 ? 44  SER A OG  1 
ATOM 351  N N   . PRO A 1 45  ? -38.872 -14.295 134.166 1.00 102.91 ? 45  PRO A N   1 
ATOM 352  C CA  . PRO A 1 45  ? -37.679 -13.448 134.222 1.00 102.91 ? 45  PRO A CA  1 
ATOM 353  C C   . PRO A 1 45  ? -37.617 -12.325 133.176 1.00 102.91 ? 45  PRO A C   1 
ATOM 354  O O   . PRO A 1 45  ? -36.535 -12.093 132.670 1.00 102.91 ? 45  PRO A O   1 
ATOM 355  C CB  . PRO A 1 45  ? -36.568 -14.472 133.944 1.00 102.91 ? 45  PRO A CB  1 
ATOM 356  C CG  . PRO A 1 45  ? -37.202 -15.424 132.959 1.00 102.91 ? 45  PRO A CG  1 
ATOM 357  C CD  . PRO A 1 45  ? -38.650 -15.519 133.394 1.00 102.91 ? 45  PRO A CD  1 
ATOM 358  N N   . GLU A 1 46  ? -38.732 -11.650 132.868 1.00 105.60 ? 46  GLU A N   1 
ATOM 359  C CA  . GLU A 1 46  ? -38.683 -10.513 131.958 1.00 105.60 ? 46  GLU A CA  1 
ATOM 360  C C   . GLU A 1 46  ? -39.509 -9.355  132.500 1.00 105.60 ? 46  GLU A C   1 
ATOM 361  O O   . GLU A 1 46  ? -40.518 -9.550  133.183 1.00 105.60 ? 46  GLU A O   1 
ATOM 362  C CB  . GLU A 1 46  ? -39.200 -10.888 130.565 1.00 105.60 ? 46  GLU A CB  1 
ATOM 363  C CG  . GLU A 1 46  ? -38.367 -11.942 129.863 1.00 105.60 ? 46  GLU A CG  1 
ATOM 364  C CD  . GLU A 1 46  ? -38.729 -13.345 130.299 1.00 105.60 ? 46  GLU A CD  1 
ATOM 365  O OE1 . GLU A 1 46  ? -39.674 -13.489 131.105 1.00 105.60 ? 46  GLU A OE1 1 
ATOM 366  O OE2 . GLU A 1 46  ? -38.072 -14.303 129.842 1.00 105.60 ? 46  GLU A OE2 1 
ATOM 367  N N   . HIS A 1 47  ? -39.061 -8.142  132.176 1.00 106.57 ? 47  HIS A N   1 
ATOM 368  C CA  . HIS A 1 47  ? -39.891 -6.941  132.260 1.00 106.57 ? 47  HIS A CA  1 
ATOM 369  C C   . HIS A 1 47  ? -40.807 -6.871  131.041 1.00 106.57 ? 47  HIS A C   1 
ATOM 370  O O   . HIS A 1 47  ? -40.534 -6.211  130.036 1.00 106.57 ? 47  HIS A O   1 
ATOM 371  C CB  . HIS A 1 47  ? -39.005 -5.706  132.397 1.00 106.57 ? 47  HIS A CB  1 
ATOM 372  C CG  . HIS A 1 47  ? -38.111 -5.457  131.222 1.00 106.57 ? 47  HIS A CG  1 
ATOM 373  N ND1 . HIS A 1 47  ? -36.919 -6.127  131.045 1.00 106.57 ? 47  HIS A ND1 1 
ATOM 374  C CD2 . HIS A 1 47  ? -38.214 -4.594  130.183 1.00 106.57 ? 47  HIS A CD2 1 
ATOM 375  C CE1 . HIS A 1 47  ? -36.337 -5.701  129.939 1.00 106.57 ? 47  HIS A CE1 1 
ATOM 376  N NE2 . HIS A 1 47  ? -37.107 -4.779  129.390 1.00 106.57 ? 47  HIS A NE2 1 
ATOM 377  N N   . CYS A 1 48  ? -41.929 -7.584  131.147 1.00 101.69 ? 48  CYS A N   1 
ATOM 378  C CA  . CYS A 1 48  ? -42.936 -7.544  130.093 1.00 101.69 ? 48  CYS A CA  1 
ATOM 379  C C   . CYS A 1 48  ? -43.474 -6.133  129.892 1.00 101.69 ? 48  CYS A C   1 
ATOM 380  O O   . CYS A 1 48  ? -43.672 -5.695  128.752 1.00 101.69 ? 48  CYS A O   1 
ATOM 381  C CB  . CYS A 1 48  ? -44.073 -8.508  130.427 1.00 101.69 ? 48  CYS A CB  1 
ATOM 382  S SG  . CYS A 1 48  ? -43.544 -10.223 130.627 1.00 101.69 ? 48  CYS A SG  1 
ATOM 383  N N   . SER A 1 49  ? -43.717 -5.408  130.980 1.00 100.05 ? 49  SER A N   1 
ATOM 384  C CA  . SER A 1 49  ? -44.051 -3.993  130.907 1.00 100.05 ? 49  SER A CA  1 
ATOM 385  C C   . SER A 1 49  ? -43.715 -3.341  132.243 1.00 100.05 ? 49  SER A C   1 
ATOM 386  O O   . SER A 1 49  ? -43.574 -4.033  133.257 1.00 100.05 ? 49  SER A O   1 
ATOM 387  C CB  . SER A 1 49  ? -45.537 -3.793  130.569 1.00 100.05 ? 49  SER A CB  1 
ATOM 388  O OG  . SER A 1 49  ? -46.338 -3.881  131.734 1.00 100.05 ? 49  SER A OG  1 
ATOM 389  N N   . PRO A 1 50  ? -43.588 -2.011  132.276 1.00 96.27  ? 50  PRO A N   1 
ATOM 390  C CA  . PRO A 1 50  ? -43.397 -1.307  133.559 1.00 96.27  ? 50  PRO A CA  1 
ATOM 391  C C   . PRO A 1 50  ? -44.521 -1.517  134.564 1.00 96.27  ? 50  PRO A C   1 
ATOM 392  O O   . PRO A 1 50  ? -44.288 -1.386  135.775 1.00 96.27  ? 50  PRO A O   1 
ATOM 393  C CB  . PRO A 1 50  ? -43.289 0.166   133.135 1.00 96.27  ? 50  PRO A CB  1 
ATOM 394  C CG  . PRO A 1 50  ? -43.980 0.232   131.817 1.00 96.27  ? 50  PRO A CG  1 
ATOM 395  C CD  . PRO A 1 50  ? -43.637 -1.066  131.150 1.00 96.27  ? 50  PRO A CD  1 
ATOM 396  N N   . HIS A 1 51  ? -45.719 -1.812  134.047 1.00 93.31  ? 51  HIS A N   1 
ATOM 397  C CA  . HIS A 1 51  ? -46.881 -2.149  134.899 1.00 93.31  ? 51  HIS A CA  1 
ATOM 398  C C   . HIS A 1 51  ? -46.523 -3.431  135.634 1.00 93.31  ? 51  HIS A C   1 
ATOM 399  O O   . HIS A 1 51  ? -46.897 -3.558  136.803 1.00 93.31  ? 51  HIS A O   1 
ATOM 400  C CB  . HIS A 1 51  ? -48.153 -2.334  134.067 1.00 93.31  ? 51  HIS A CB  1 
ATOM 401  C CG  . HIS A 1 51  ? -48.620 -1.110  133.357 1.00 93.31  ? 51  HIS A CG  1 
ATOM 402  N ND1 . HIS A 1 51  ? -49.400 -0.155  133.973 1.00 93.31  ? 51  HIS A ND1 1 
ATOM 403  C CD2 . HIS A 1 51  ? -48.451 -0.700  132.084 1.00 93.31  ? 51  HIS A CD2 1 
ATOM 404  C CE1 . HIS A 1 51  ? -49.678 0.803   133.113 1.00 93.31  ? 51  HIS A CE1 1 
ATOM 405  N NE2 . HIS A 1 51  ? -49.107 0.492   131.946 1.00 93.31  ? 51  HIS A NE2 1 
ATOM 406  N N   . HIS A 1 52  ? -45.818 -4.345  134.970 1.00 94.40  ? 52  HIS A N   1 
ATOM 407  C CA  . HIS A 1 52  ? -45.386 -5.625  135.583 1.00 94.40  ? 52  HIS A CA  1 
ATOM 408  C C   . HIS A 1 52  ? -44.363 -5.322  136.677 1.00 94.40  ? 52  HIS A C   1 
ATOM 409  O O   . HIS A 1 52  ? -44.422 -5.991  137.717 1.00 94.40  ? 52  HIS A O   1 
ATOM 410  C CB  . HIS A 1 52  ? -44.851 -6.584  134.519 1.00 94.40  ? 52  HIS A CB  1 
ATOM 411  C CG  . HIS A 1 52  ? -45.911 -7.302  133.756 1.00 94.40  ? 52  HIS A CG  1 
ATOM 412  N ND1 . HIS A 1 52  ? -46.332 -6.888  132.511 1.00 94.40  ? 52  HIS A ND1 1 
ATOM 413  C CD2 . HIS A 1 52  ? -46.625 -8.408  134.050 1.00 94.40  ? 52  HIS A CD2 1 
ATOM 414  C CE1 . HIS A 1 52  ? -47.266 -7.704  132.072 1.00 94.40  ? 52  HIS A CE1 1 
ATOM 415  N NE2 . HIS A 1 52  ? -47.463 -8.645  132.997 1.00 94.40  ? 52  HIS A NE2 1 
ATOM 416  N N   . THR A 1 53  ? -43.485 -4.340  136.476 1.00 93.27  ? 53  THR A N   1 
ATOM 417  C CA  . THR A 1 53  ? -42.423 -3.975  137.451 1.00 93.27  ? 53  THR A CA  1 
ATOM 418  C C   . THR A 1 53  ? -43.033 -3.349  138.703 1.00 93.27  ? 53  THR A C   1 
ATOM 419  O O   . THR A 1 53  ? -42.702 -3.816  139.797 1.00 93.27  ? 53  THR A O   1 
ATOM 420  C CB  . THR A 1 53  ? -41.428 -3.003  136.818 1.00 93.27  ? 53  THR A CB  1 
ATOM 421  O OG1 . THR A 1 53  ? -40.904 -3.627  135.647 1.00 93.27  ? 53  THR A OG1 1 
ATOM 422  C CG2 . THR A 1 53  ? -40.303 -2.620  137.753 1.00 93.27  ? 53  THR A CG2 1 
ATOM 423  N N   . ALA A 1 54  ? -43.884 -2.343  138.552 1.00 92.26  ? 54  ALA A N   1 
ATOM 424  C CA  . ALA A 1 54  ? -44.521 -1.615  139.647 1.00 92.26  ? 54  ALA A CA  1 
ATOM 425  C C   . ALA A 1 54  ? -45.340 -2.544  140.532 1.00 92.26  ? 54  ALA A C   1 
ATOM 426  O O   . ALA A 1 54  ? -45.297 -2.441  141.767 1.00 92.26  ? 54  ALA A O   1 
ATOM 427  C CB  . ALA A 1 54  ? -45.401 -0.500  139.087 1.00 92.26  ? 54  ALA A CB  1 
ATOM 428  N N   . LEU A 1 55  ? -46.036 -3.484  139.902 1.00 94.67  ? 55  LEU A N   1 
ATOM 429  C CA  . LEU A 1 55  ? -46.896 -4.437  140.634 1.00 94.67  ? 55  LEU A CA  1 
ATOM 430  C C   . LEU A 1 55  ? -46.021 -5.309  141.536 1.00 94.67  ? 55  LEU A C   1 
ATOM 431  O O   . LEU A 1 55  ? -46.366 -5.438  142.721 1.00 94.67  ? 55  LEU A O   1 
ATOM 432  C CB  . LEU A 1 55  ? -47.668 -5.255  139.599 1.00 94.67  ? 55  LEU A CB  1 
ATOM 433  C CG  . LEU A 1 55  ? -48.838 -6.073  140.134 1.00 94.67  ? 55  LEU A CG  1 
ATOM 434  C CD1 . LEU A 1 55  ? -49.715 -5.240  141.053 1.00 94.67  ? 55  LEU A CD1 1 
ATOM 435  C CD2 . LEU A 1 55  ? -49.656 -6.644  138.990 1.00 94.67  ? 55  LEU A CD2 1 
ATOM 436  N N   . ARG A 1 56  ? -44.907 -5.831  141.030 1.00 94.27  ? 56  ARG A N   1 
ATOM 437  C CA  . ARG A 1 56  ? -44.012 -6.731  141.803 1.00 94.27  ? 56  ARG A CA  1 
ATOM 438  C C   . ARG A 1 56  ? -43.565 -6.033  143.088 1.00 94.27  ? 56  ARG A C   1 
ATOM 439  O O   . ARG A 1 56  ? -43.786 -6.601  144.207 1.00 94.27  ? 56  ARG A O   1 
ATOM 440  C CB  . ARG A 1 56  ? -42.817 -7.113  140.929 1.00 94.27  ? 56  ARG A CB  1 
ATOM 441  C CG  . ARG A 1 56  ? -43.156 -8.083  139.807 1.00 94.27  ? 56  ARG A CG  1 
ATOM 442  C CD  . ARG A 1 56  ? -42.171 -7.995  138.660 1.00 94.27  ? 56  ARG A CD  1 
ATOM 443  N NE  . ARG A 1 56  ? -42.474 -8.959  137.615 1.00 94.27  ? 56  ARG A NE  1 
ATOM 444  C CZ  . ARG A 1 56  ? -41.969 -8.932  136.387 1.00 94.27  ? 56  ARG A CZ  1 
ATOM 445  N NH1 . ARG A 1 56  ? -41.135 -7.973  136.025 1.00 94.27  ? 56  ARG A NH1 1 
ATOM 446  N NH2 . ARG A 1 56  ? -42.315 -9.859  135.515 1.00 94.27  ? 56  ARG A NH2 1 
ATOM 447  N N   . GLN A 1 57  ? -43.004 -4.835  142.962 1.00 94.21  ? 57  GLN A N   1 
ATOM 448  C CA  . GLN A 1 57  ? -42.501 -4.071  144.129 1.00 94.21  ? 57  GLN A CA  1 
ATOM 449  C C   . GLN A 1 57  ? -43.641 -3.897  145.130 1.00 94.21  ? 57  GLN A C   1 
ATOM 450  O O   . GLN A 1 57  ? -43.433 -4.209  146.319 1.00 94.21  ? 57  GLN A O   1 
ATOM 451  C CB  . GLN A 1 57  ? -41.989 -2.703  143.684 1.00 94.21  ? 57  GLN A CB  1 
ATOM 452  C CG  . GLN A 1 57  ? -41.000 -2.738  142.530 1.00 94.21  ? 57  GLN A CG  1 
ATOM 453  C CD  . GLN A 1 57  ? -39.835 -3.666  142.773 1.00 94.21  ? 57  GLN A CD  1 
ATOM 454  O OE1 . GLN A 1 57  ? -39.359 -3.807  143.896 1.00 94.21  ? 57  GLN A OE1 1 
ATOM 455  N NE2 . GLN A 1 57  ? -39.364 -4.304  141.716 1.00 94.21  ? 57  GLN A NE2 1 
ATOM 456  N N   . ALA A 1 58  ? -44.812 -3.459  144.676 1.00 94.99  ? 58  ALA A N   1 
ATOM 457  C CA  . ALA A 1 58  ? -45.968 -3.192  145.559 1.00 94.99  ? 58  ALA A CA  1 
ATOM 458  C C   . ALA A 1 58  ? -46.337 -4.460  146.326 1.00 94.99  ? 58  ALA A C   1 
ATOM 459  O O   . ALA A 1 58  ? -46.504 -4.382  147.567 1.00 94.99  ? 58  ALA A O   1 
ATOM 460  C CB  . ALA A 1 58  ? -47.108 -2.702  144.716 1.00 94.99  ? 58  ALA A CB  1 
ATOM 461  N N   . ILE A 1 59  ? -46.437 -5.590  145.633 1.00 96.21  ? 59  ILE A N   1 
ATOM 462  C CA  . ILE A 1 59  ? -46.787 -6.893  146.262 1.00 96.21  ? 59  ILE A CA  1 
ATOM 463  C C   . ILE A 1 59  ? -45.752 -7.212  147.347 1.00 96.21  ? 59  ILE A C   1 
ATOM 464  O O   . ILE A 1 59  ? -46.170 -7.470  148.494 1.00 96.21  ? 59  ILE A O   1 
ATOM 465  C CB  . ILE A 1 59  ? -46.882 -7.982  145.179 1.00 96.21  ? 59  ILE A CB  1 
ATOM 466  C CG1 . ILE A 1 59  ? -48.021 -7.693  144.200 1.00 96.21  ? 59  ILE A CG1 1 
ATOM 467  C CG2 . ILE A 1 59  ? -47.017 -9.360  145.802 1.00 96.21  ? 59  ILE A CG2 1 
ATOM 468  C CD1 . ILE A 1 59  ? -47.891 -8.413  142.883 1.00 96.21  ? 59  ILE A CD1 1 
ATOM 469  N N   . LEU A 1 60  ? -44.457 -7.134  147.032 1.00 98.54  ? 60  LEU A N   1 
ATOM 470  C CA  . LEU A 1 60  ? -43.378 -7.422  148.023 1.00 98.54  ? 60  LEU A CA  1 
ATOM 471  C C   . LEU A 1 60  ? -43.511 -6.501  149.243 1.00 98.54  ? 60  LEU A C   1 
ATOM 472  O O   . LEU A 1 60  ? -43.331 -6.991  150.393 1.00 98.54  ? 60  LEU A O   1 
ATOM 473  C CB  . LEU A 1 60  ? -42.017 -7.239  147.350 1.00 98.54  ? 60  LEU A CB  1 
ATOM 474  C CG  . LEU A 1 60  ? -41.672 -8.269  146.277 1.00 98.54  ? 60  LEU A CG  1 
ATOM 475  C CD1 . LEU A 1 60  ? -40.343 -7.943  145.618 1.00 98.54  ? 60  LEU A CD1 1 
ATOM 476  C CD2 . LEU A 1 60  ? -41.643 -9.670  146.861 1.00 98.54  ? 60  LEU A CD2 1 
ATOM 477  N N   . CYS A 1 61  ? -43.814 -5.222  149.036 1.00 104.45 ? 61  CYS A N   1 
ATOM 478  C CA  . CYS A 1 61  ? -43.956 -4.230  150.134 1.00 104.45 ? 61  CYS A CA  1 
ATOM 479  C C   . CYS A 1 61  ? -45.138 -4.601  151.032 1.00 104.45 ? 61  CYS A C   1 
ATOM 480  O O   . CYS A 1 61  ? -44.978 -4.585  152.287 1.00 104.45 ? 61  CYS A O   1 
ATOM 481  C CB  . CYS A 1 61  ? -44.152 -2.834  149.563 1.00 104.45 ? 61  CYS A CB  1 
ATOM 482  S SG  . CYS A 1 61  ? -44.427 -1.576  150.835 1.00 104.45 ? 61  CYS A SG  1 
ATOM 483  N N   . TRP A 1 62  ? -46.279 -4.952  150.439 1.00 99.16  ? 62  TRP A N   1 
ATOM 484  C CA  . TRP A 1 62  ? -47.449 -5.384  151.240 1.00 99.16  ? 62  TRP A CA  1 
ATOM 485  C C   . TRP A 1 62  ? -47.033 -6.617  152.037 1.00 99.16  ? 62  TRP A C   1 
ATOM 486  O O   . TRP A 1 62  ? -47.395 -6.699  153.210 1.00 99.16  ? 62  TRP A O   1 
ATOM 487  C CB  . TRP A 1 62  ? -48.679 -5.660  150.377 1.00 99.16  ? 62  TRP A CB  1 
ATOM 488  C CG  . TRP A 1 62  ? -49.888 -5.989  151.195 1.00 99.16  ? 62  TRP A CG  1 
ATOM 489  C CD1 . TRP A 1 62  ? -50.472 -7.210  151.352 1.00 99.16  ? 62  TRP A CD1 1 
ATOM 490  C CD2 . TRP A 1 62  ? -50.643 -5.077  152.009 1.00 99.16  ? 62  TRP A CD2 1 
ATOM 491  N NE1 . TRP A 1 62  ? -51.547 -7.119  152.194 1.00 99.16  ? 62  TRP A NE1 1 
ATOM 492  C CE2 . TRP A 1 62  ? -51.677 -5.822  152.612 1.00 99.16  ? 62  TRP A CE2 1 
ATOM 493  C CE3 . TRP A 1 62  ? -50.553 -3.708  152.279 1.00 99.16  ? 62  TRP A CE3 1 
ATOM 494  C CZ2 . TRP A 1 62  ? -52.611 -5.240  153.466 1.00 99.16  ? 62  TRP A CZ2 1 
ATOM 495  C CZ3 . TRP A 1 62  ? -51.476 -3.134  153.123 1.00 99.16  ? 62  TRP A CZ3 1 
ATOM 496  C CH2 . TRP A 1 62  ? -52.489 -3.892  153.708 1.00 99.16  ? 62  TRP A CH2 1 
ATOM 497  N N   . GLY A 1 63  ? -46.284 -7.528  151.422 1.00 103.16 ? 63  GLY A N   1 
ATOM 498  C CA  . GLY A 1 63  ? -45.803 -8.737  152.112 1.00 103.16 ? 63  GLY A CA  1 
ATOM 499  C C   . GLY A 1 63  ? -45.014 -8.368  153.349 1.00 103.16 ? 63  GLY A C   1 
ATOM 500  O O   . GLY A 1 63  ? -45.342 -8.888  154.434 1.00 103.16 ? 63  GLY A O   1 
ATOM 501  N N   . GLU A 1 64  ? -44.038 -7.471  153.215 1.00 104.90 ? 64  GLU A N   1 
ATOM 502  C CA  . GLU A 1 64  ? -43.207 -7.032  154.367 1.00 104.90 ? 64  GLU A CA  1 
ATOM 503  C C   . GLU A 1 64  ? -44.103 -6.417  155.445 1.00 104.90 ? 64  GLU A C   1 
ATOM 504  O O   . GLU A 1 64  ? -43.890 -6.725  156.626 1.00 104.90 ? 64  GLU A O   1 
ATOM 505  C CB  . GLU A 1 64  ? -42.138 -6.041  153.913 1.00 104.90 ? 64  GLU A CB  1 
ATOM 506  C CG  . GLU A 1 64  ? -41.125 -6.644  152.961 1.00 104.90 ? 64  GLU A CG  1 
ATOM 507  C CD  . GLU A 1 64  ? -40.383 -7.851  153.509 1.00 104.90 ? 64  GLU A CD  1 
ATOM 508  O OE1 . GLU A 1 64  ? -40.023 -8.730  152.707 1.00 104.90 ? 64  GLU A OE1 1 
ATOM 509  O OE2 . GLU A 1 64  ? -40.166 -7.905  154.734 1.00 104.90 ? 64  GLU A OE2 1 
ATOM 510  N N   . LEU A 1 65  ? -45.068 -5.579  155.062 1.00 104.05 ? 65  LEU A N   1 
ATOM 511  C CA  . LEU A 1 65  ? -45.970 -4.915  156.043 1.00 104.05 ? 65  LEU A CA  1 
ATOM 512  C C   . LEU A 1 65  ? -46.778 -5.971  156.802 1.00 104.05 ? 65  LEU A C   1 
ATOM 513  O O   . LEU A 1 65  ? -46.939 -5.825  158.025 1.00 104.05 ? 65  LEU A O   1 
ATOM 514  C CB  . LEU A 1 65  ? -46.892 -3.944  155.306 1.00 104.05 ? 65  LEU A CB  1 
ATOM 515  C CG  . LEU A 1 65  ? -46.250 -2.631  154.870 1.00 104.05 ? 65  LEU A CG  1 
ATOM 516  C CD1 . LEU A 1 65  ? -47.170 -1.870  153.932 1.00 104.05 ? 65  LEU A CD1 1 
ATOM 517  C CD2 . LEU A 1 65  ? -45.893 -1.781  156.076 1.00 104.05 ? 65  LEU A CD2 1 
ATOM 518  N N   . MET A 1 66  ? -47.270 -6.997  156.112 1.00 107.55 ? 66  MET A N   1 
ATOM 519  C CA  . MET A 1 66  ? -48.072 -8.075  156.743 1.00 107.55 ? 66  MET A CA  1 
ATOM 520  C C   . MET A 1 66  ? -47.165 -8.881  157.671 1.00 107.55 ? 66  MET A C   1 
ATOM 521  O O   . MET A 1 66  ? -47.655 -9.320  158.719 1.00 107.55 ? 66  MET A O   1 
ATOM 522  C CB  . MET A 1 66  ? -48.691 -9.000  155.694 1.00 107.55 ? 66  MET A CB  1 
ATOM 523  C CG  . MET A 1 66  ? -49.715 -8.316  154.814 1.00 107.55 ? 66  MET A CG  1 
ATOM 524  S SD  . MET A 1 66  ? -50.957 -7.413  155.768 1.00 107.55 ? 66  MET A SD  1 
ATOM 525  C CE  . MET A 1 66  ? -51.575 -8.725  156.820 1.00 107.55 ? 66  MET A CE  1 
ATOM 526  N N   . THR A 1 67  ? -45.902 -9.088  157.300 1.00 110.06 ? 67  THR A N   1 
ATOM 527  C CA  . THR A 1 67  ? -44.920 -9.784  158.168 1.00 110.06 ? 67  THR A CA  1 
ATOM 528  C C   . THR A 1 67  ? -44.740 -8.958  159.439 1.00 110.06 ? 67  THR A C   1 
ATOM 529  O O   . THR A 1 67  ? -44.671 -9.565  160.515 1.00 110.06 ? 67  THR A O   1 
ATOM 530  C CB  . THR A 1 67  ? -43.576 -9.982  157.466 1.00 110.06 ? 67  THR A CB  1 
ATOM 531  O OG1 . THR A 1 67  ? -43.782 -10.846 156.347 1.00 110.06 ? 67  THR A OG1 1 
ATOM 532  C CG2 . THR A 1 67  ? -42.522 -10.567 158.377 1.00 110.06 ? 67  THR A CG2 1 
ATOM 533  N N   . LEU A 1 68  ? -44.661 -7.632  159.312 1.00 110.73 ? 68  LEU A N   1 
ATOM 534  C CA  . LEU A 1 68  ? -44.513 -6.722  160.480 1.00 110.73 ? 68  LEU A CA  1 
ATOM 535  C C   . LEU A 1 68  ? -45.762 -6.822  161.343 1.00 110.73 ? 68  LEU A C   1 
ATOM 536  O O   . LEU A 1 68  ? -45.627 -6.722  162.560 1.00 110.73 ? 68  LEU A O   1 
ATOM 537  C CB  . LEU A 1 68  ? -44.331 -5.286  159.992 1.00 110.73 ? 68  LEU A CB  1 
ATOM 538  C CG  . LEU A 1 68  ? -44.609 -4.195  161.022 1.00 110.73 ? 68  LEU A CG  1 
ATOM 539  C CD1 . LEU A 1 68  ? -43.666 -4.306  162.207 1.00 110.73 ? 68  LEU A CD1 1 
ATOM 540  C CD2 . LEU A 1 68  ? -44.495 -2.824  160.381 1.00 110.73 ? 68  LEU A CD2 1 
ATOM 541  N N   . ALA A 1 69  ? -46.933 -6.963  160.727 1.00 112.77 ? 69  ALA A N   1 
ATOM 542  C CA  . ALA A 1 69  ? -48.210 -7.100  161.459 1.00 112.77 ? 69  ALA A CA  1 
ATOM 543  C C   . ALA A 1 69  ? -48.168 -8.382  162.283 1.00 112.77 ? 69  ALA A C   1 
ATOM 544  O O   . ALA A 1 69  ? -48.799 -8.415  163.348 1.00 112.77 ? 69  ALA A O   1 
ATOM 545  C CB  . ALA A 1 69  ? -49.359 -7.113  160.491 1.00 112.77 ? 69  ALA A CB  1 
ATOM 546  N N   . THR A 1 70  ? -47.475 -9.409  161.790 1.00 114.57 ? 70  THR A N   1 
ATOM 547  C CA  . THR A 1 70  ? -47.332 -10.655 162.538 1.00 114.57 ? 70  THR A CA  1 
ATOM 548  C C   . THR A 1 70  ? -46.367 -10.492 163.708 1.00 114.57 ? 70  THR A C   1 
ATOM 549  O O   . THR A 1 70  ? -46.620 -11.005 164.804 1.00 114.57 ? 70  THR A O   1 
ATOM 550  C CB  . THR A 1 70  ? -46.865 -11.778 161.615 1.00 114.57 ? 70  THR A CB  1 
ATOM 551  O OG1 . THR A 1 70  ? -47.756 -11.878 160.498 1.00 114.57 ? 70  THR A OG1 1 
ATOM 552  C CG2 . THR A 1 70  ? -46.840 -13.105 162.361 1.00 114.57 ? 70  THR A CG2 1 
ATOM 553  N N   . TRP A 1 71  ? -45.259 -9.786  163.492 1.00 117.29 ? 71  TRP A N   1 
ATOM 554  C CA  . TRP A 1 71  ? -44.309 -9.541  164.576 1.00 117.29 ? 71  TRP A CA  1 
ATOM 555  C C   . TRP A 1 71  ? -44.924 -8.713  165.705 1.00 117.29 ? 71  TRP A C   1 
ATOM 556  O O   . TRP A 1 71  ? -44.776 -9.050  166.890 1.00 117.29 ? 71  TRP A O   1 
ATOM 557  C CB  . TRP A 1 71  ? -43.082 -8.841  163.989 1.00 117.29 ? 71  TRP A CB  1 
ATOM 558  C CG  . TRP A 1 71  ? -41.906 -8.670  164.898 1.00 117.29 ? 71  TRP A CG  1 
ATOM 559  C CD1 . TRP A 1 71  ? -40.806 -9.469  164.975 1.00 117.29 ? 71  TRP A CD1 1 
ATOM 560  C CD2 . TRP A 1 71  ? -41.719 -7.635  165.871 1.00 117.29 ? 71  TRP A CD2 1 
ATOM 561  N NE1 . TRP A 1 71  ? -39.938 -8.990  165.926 1.00 117.29 ? 71  TRP A NE1 1 
ATOM 562  C CE2 . TRP A 1 71  ? -40.470 -7.857  166.481 1.00 117.29 ? 71  TRP A CE2 1 
ATOM 563  C CE3 . TRP A 1 71  ? -42.482 -6.537  166.277 1.00 117.29 ? 71  TRP A CE3 1 
ATOM 564  C CZ2 . TRP A 1 71  ? -39.970 -7.025  167.480 1.00 117.29 ? 71  TRP A CZ2 1 
ATOM 565  C CZ3 . TRP A 1 71  ? -41.981 -5.710  167.263 1.00 117.29 ? 71  TRP A CZ3 1 
ATOM 566  C CH2 . TRP A 1 71  ? -40.737 -5.959  167.854 1.00 117.29 ? 71  TRP A CH2 1 
ATOM 567  N N   . VAL A 1 72  ? -45.627 -7.632  165.360 1.00 121.76 ? 72  VAL A N   1 
ATOM 568  C CA  . VAL A 1 72  ? -46.296 -6.830  166.384 1.00 121.76 ? 72  VAL A CA  1 
ATOM 569  C C   . VAL A 1 72  ? -47.300 -7.681  167.152 1.00 121.76 ? 72  VAL A C   1 
ATOM 570  O O   . VAL A 1 72  ? -47.395 -7.595  168.382 1.00 121.76 ? 72  VAL A O   1 
ATOM 571  C CB  . VAL A 1 72  ? -46.938 -5.568  165.774 1.00 121.76 ? 72  VAL A CB  1 
ATOM 572  C CG1 . VAL A 1 72  ? -48.164 -5.892  164.946 1.00 121.76 ? 72  VAL A CG1 1 
ATOM 573  C CG2 . VAL A 1 72  ? -47.293 -4.584  166.869 1.00 121.76 ? 72  VAL A CG2 1 
ATOM 574  N N   . GLY A 1 73  ? -48.057 -8.526  166.444 1.00 124.60 ? 73  GLY A N   1 
ATOM 575  C CA  . GLY A 1 73  ? -49.061 -9.338  167.108 1.00 124.60 ? 73  GLY A CA  1 
ATOM 576  C C   . GLY A 1 73  ? -48.502 -10.234 168.197 1.00 124.60 ? 73  GLY A C   1 
ATOM 577  O O   . GLY A 1 73  ? -49.205 -10.560 169.157 1.00 124.60 ? 73  GLY A O   1 
ATOM 578  N N   . VAL A 1 74  ? -47.240 -10.636 168.074 1.00 126.28 ? 74  VAL A N   1 
ATOM 579  C CA  . VAL A 1 74  ? -46.617 -11.493 169.075 1.00 126.28 ? 74  VAL A CA  1 
ATOM 580  C C   . VAL A 1 74  ? -45.860 -10.727 170.154 1.00 126.28 ? 74  VAL A C   1 
ATOM 581  O O   . VAL A 1 74  ? -45.968 -11.069 171.336 1.00 126.28 ? 74  VAL A O   1 
ATOM 582  C CB  . VAL A 1 74  ? -45.645 -12.488 168.415 1.00 30.00  ? 74  VAL A CB  1 
ATOM 583  C CG1 . VAL A 1 74  ? -44.928 -13.315 169.472 1.00 30.00  ? 74  VAL A CG1 1 
ATOM 584  C CG2 . VAL A 1 74  ? -46.386 -13.388 167.438 1.00 30.00  ? 74  VAL A CG2 1 
ATOM 585  N N   . ASN A 1 75  ? -45.100 -9.694  169.792 1.00 124.81 ? 75  ASN A N   1 
ATOM 586  C CA  . ASN A 1 75  ? -44.072 -9.193  170.699 1.00 124.81 ? 75  ASN A CA  1 
ATOM 587  C C   . ASN A 1 75  ? -44.531 -8.066  171.618 1.00 124.81 ? 75  ASN A C   1 
ATOM 588  O O   . ASN A 1 75  ? -43.892 -7.846  172.653 1.00 124.81 ? 75  ASN A O   1 
ATOM 589  C CB  . ASN A 1 75  ? -42.837 -8.750  169.914 1.00 124.81 ? 75  ASN A CB  1 
ATOM 590  C CG  . ASN A 1 75  ? -42.099 -9.922  169.302 1.00 124.81 ? 75  ASN A CG  1 
ATOM 591  O OD1 . ASN A 1 75  ? -42.607 -11.042 169.275 1.00 124.81 ? 75  ASN A OD1 1 
ATOM 592  N ND2 . ASN A 1 75  ? -40.875 -9.684  168.856 1.00 124.81 ? 75  ASN A ND2 1 
ATOM 593  N N   . LEU A 1 76  ? -45.601 -7.349  171.288 1.00 130.56 ? 76  LEU A N   1 
ATOM 594  C CA  . LEU A 1 76  ? -46.196 -6.418  172.241 1.00 130.56 ? 76  LEU A CA  1 
ATOM 595  C C   . LEU A 1 76  ? -47.197 -7.137  173.139 1.00 130.56 ? 76  LEU A C   1 
ATOM 596  O O   . LEU A 1 76  ? -48.002 -7.951  172.677 1.00 130.56 ? 76  LEU A O   1 
ATOM 597  C CB  . LEU A 1 76  ? -46.884 -5.260  171.516 1.00 130.56 ? 76  LEU A CB  1 
ATOM 598  C CG  . LEU A 1 76  ? -46.019 -4.437  170.560 1.00 130.56 ? 76  LEU A CG  1 
ATOM 599  C CD1 . LEU A 1 76  ? -46.754 -3.166  170.163 1.00 130.56 ? 76  LEU A CD1 1 
ATOM 600  C CD2 . LEU A 1 76  ? -44.668 -4.106  171.180 1.00 130.56 ? 76  LEU A CD2 1 
ATOM 601  N N   . GLU A 1 77  ? -47.132 -6.819  174.432 1.00 140.54 ? 77  GLU A N   1 
ATOM 602  C CA  . GLU A 1 77  ? -47.976 -7.399  175.474 1.00 140.54 ? 77  GLU A CA  1 
ATOM 603  C C   . GLU A 1 77  ? -49.209 -6.566  175.799 1.00 140.54 ? 77  GLU A C   1 
ATOM 604  O O   . GLU A 1 77  ? -50.258 -7.132  176.121 1.00 140.54 ? 77  GLU A O   1 
ATOM 605  C CB  . GLU A 1 77  ? -47.166 -7.604  176.759 1.00 140.54 ? 77  GLU A CB  1 
ATOM 606  C CG  . GLU A 1 77  ? -46.757 -6.321  177.464 1.00 140.54 ? 77  GLU A CG  1 
ATOM 607  C CD  . GLU A 1 77  ? -45.480 -5.727  176.905 1.00 140.54 ? 77  GLU A CD  1 
ATOM 608  O OE1 . GLU A 1 77  ? -45.034 -6.180  175.831 1.00 140.54 ? 77  GLU A OE1 1 
ATOM 609  O OE2 . GLU A 1 77  ? -44.918 -4.812  177.543 1.00 140.54 ? 77  GLU A OE2 1 
ATOM 610  N N   . ASP A 1 78  ? -49.114 -5.245  175.737 1.00 138.43 ? 78  ASP A N   1 
ATOM 611  C CA  . ASP A 1 78  ? -50.297 -4.410  175.898 1.00 138.43 ? 78  ASP A CA  1 
ATOM 612  C C   . ASP A 1 78  ? -51.236 -4.626  174.718 1.00 138.43 ? 78  ASP A C   1 
ATOM 613  O O   . ASP A 1 78  ? -50.877 -4.291  173.582 1.00 138.43 ? 78  ASP A O   1 
ATOM 614  C CB  . ASP A 1 78  ? -49.904 -2.940  175.997 1.00 138.43 ? 78  ASP A CB  1 
ATOM 615  C CG  . ASP A 1 78  ? -51.105 -2.019  176.058 1.00 138.43 ? 78  ASP A CG  1 
ATOM 616  O OD1 . ASP A 1 78  ? -51.586 -1.725  177.174 1.00 138.43 ? 78  ASP A OD1 1 
ATOM 617  O OD2 . ASP A 1 78  ? -51.577 -1.598  174.983 1.00 138.43 ? 78  ASP A OD2 1 
ATOM 618  N N   . PRO A 1 79  ? -52.440 -5.170  174.933 1.00 135.06 ? 79  PRO A N   1 
ATOM 619  C CA  . PRO A 1 79  ? -53.349 -5.398  173.800 1.00 135.06 ? 79  PRO A CA  1 
ATOM 620  C C   . PRO A 1 79  ? -53.843 -4.123  173.142 1.00 135.06 ? 79  PRO A C   1 
ATOM 621  O O   . PRO A 1 79  ? -54.092 -4.126  171.931 1.00 135.06 ? 79  PRO A O   1 
ATOM 622  C CB  . PRO A 1 79  ? -54.504 -6.189  174.432 1.00 135.06 ? 79  PRO A CB  1 
ATOM 623  C CG  . PRO A 1 79  ? -54.498 -5.786  175.854 1.00 135.06 ? 79  PRO A CG  1 
ATOM 624  C CD  . PRO A 1 79  ? -53.048 -5.584  176.208 1.00 135.06 ? 79  PRO A CD  1 
ATOM 625  N N   . ALA A 1 80  ? -53.982 -3.031  173.891 1.00 134.31 ? 80  ALA A N   1 
ATOM 626  C CA  . ALA A 1 80  ? -54.582 -1.818  173.342 1.00 134.31 ? 80  ALA A CA  1 
ATOM 627  C C   . ALA A 1 80  ? -53.709 -1.202  172.254 1.00 134.31 ? 80  ALA A C   1 
ATOM 628  O O   . ALA A 1 80  ? -54.187 -0.908  171.150 1.00 134.31 ? 80  ALA A O   1 
ATOM 629  C CB  . ALA A 1 80  ? -54.830 -0.813  174.468 1.00 134.31 ? 80  ALA A CB  1 
ATOM 630  N N   . SER A 1 81  ? -52.421 -1.021  172.538 1.00 134.18 ? 81  SER A N   1 
ATOM 631  C CA  . SER A 1 81  ? -51.490 -0.536  171.524 1.00 134.18 ? 81  SER A CA  1 
ATOM 632  C C   . SER A 1 81  ? -51.350 -1.507  170.357 1.00 134.18 ? 81  SER A C   1 
ATOM 633  O O   . SER A 1 81  ? -51.267 -1.086  169.198 1.00 134.18 ? 81  SER A O   1 
ATOM 634  C CB  . SER A 1 81  ? -50.129 -0.293  172.171 1.00 134.18 ? 81  SER A CB  1 
ATOM 635  O OG  . SER A 1 81  ? -49.687 -1.441  172.876 1.00 134.18 ? 81  SER A OG  1 
ATOM 636  N N   . ARG A 1 82  ? -51.305 -2.806  170.641 1.00 130.76 ? 82  ARG A N   1 
ATOM 637  C CA  . ARG A 1 82  ? -51.222 -3.806  169.579 1.00 130.76 ? 82  ARG A CA  1 
ATOM 638  C C   . ARG A 1 82  ? -52.400 -3.710  168.610 1.00 130.76 ? 82  ARG A C   1 
ATOM 639  O O   . ARG A 1 82  ? -52.215 -3.658  167.384 1.00 130.76 ? 82  ARG A O   1 
ATOM 640  C CB  . ARG A 1 82  ? -51.147 -5.190  170.225 1.00 130.76 ? 82  ARG A CB  1 
ATOM 641  C CG  . ARG A 1 82  ? -50.825 -6.344  169.306 1.00 130.76 ? 82  ARG A CG  1 
ATOM 642  C CD  . ARG A 1 82  ? -50.562 -7.592  170.139 1.00 130.76 ? 82  ARG A CD  1 
ATOM 643  N NE  . ARG A 1 82  ? -51.770 -8.097  170.782 1.00 130.76 ? 82  ARG A NE  1 
ATOM 644  C CZ  . ARG A 1 82  ? -51.788 -8.757  171.935 1.00 130.76 ? 82  ARG A CZ  1 
ATOM 645  N NH1 . ARG A 1 82  ? -50.683 -8.965  172.634 1.00 130.76 ? 82  ARG A NH1 1 
ATOM 646  N NH2 . ARG A 1 82  ? -52.948 -9.203  172.408 1.00 130.76 ? 82  ARG A NH2 1 
ATOM 647  N N   . ASP A 1 83  ? -53.620 -3.635  169.143 1.00 128.20 ? 83  ASP A N   1 
ATOM 648  C CA  . ASP A 1 83  ? -54.794 -3.429  168.300 1.00 128.20 ? 83  ASP A CA  1 
ATOM 649  C C   . ASP A 1 83  ? -54.737 -2.102  167.551 1.00 128.20 ? 83  ASP A C   1 
ATOM 650  O O   . ASP A 1 83  ? -55.075 -2.041  166.365 1.00 128.20 ? 83  ASP A O   1 
ATOM 651  C CB  . ASP A 1 83  ? -56.069 -3.514  169.140 1.00 128.20 ? 83  ASP A CB  1 
ATOM 652  C CG  . ASP A 1 83  ? -56.282 -4.888  169.741 1.00 128.20 ? 83  ASP A CG  1 
ATOM 653  O OD1 . ASP A 1 83  ? -56.545 -5.833  168.970 1.00 128.20 ? 83  ASP A OD1 1 
ATOM 654  O OD2 . ASP A 1 83  ? -56.189 -5.029  170.976 1.00 128.20 ? 83  ASP A OD2 1 
ATOM 655  N N   . LEU A 1 84  ? -54.371 -1.016  168.233 1.00 124.76 ? 84  LEU A N   1 
ATOM 656  C CA  . LEU A 1 84  ? -54.314 0.271   167.545 1.00 124.76 ? 84  LEU A CA  1 
ATOM 657  C C   . LEU A 1 84  ? -53.357 0.231   166.359 1.00 124.76 ? 84  LEU A C   1 
ATOM 658  O O   . LEU A 1 84  ? -53.685 0.709   165.264 1.00 124.76 ? 84  LEU A O   1 
ATOM 659  C CB  . LEU A 1 84  ? -53.894 1.370   168.523 1.00 124.76 ? 84  LEU A CB  1 
ATOM 660  C CG  . LEU A 1 84  ? -54.967 1.878   169.485 1.00 124.76 ? 84  LEU A CG  1 
ATOM 661  C CD1 . LEU A 1 84  ? -54.348 2.749   170.566 1.00 124.76 ? 84  LEU A CD1 1 
ATOM 662  C CD2 . LEU A 1 84  ? -56.047 2.643   168.737 1.00 124.76 ? 84  LEU A CD2 1 
ATOM 663  N N   . VAL A 1 85  ? -52.190 -0.388  166.543 1.00 121.83 ? 85  VAL A N   1 
ATOM 664  C CA  . VAL A 1 85  ? -51.217 -0.515  165.459 1.00 121.83 ? 85  VAL A CA  1 
ATOM 665  C C   . VAL A 1 85  ? -51.778 -1.351  164.315 1.00 121.83 ? 85  VAL A C   1 
ATOM 666  O O   . VAL A 1 85  ? -51.662 -0.979  163.140 1.00 121.83 ? 85  VAL A O   1 
ATOM 667  C CB  . VAL A 1 85  ? -49.899 -1.105  165.993 1.00 121.83 ? 85  VAL A CB  1 
ATOM 668  C CG1 . VAL A 1 85  ? -48.932 -1.370  164.852 1.00 121.83 ? 85  VAL A CG1 1 
ATOM 669  C CG2 . VAL A 1 85  ? -49.265 -0.161  167.000 1.00 121.83 ? 85  VAL A CG2 1 
ATOM 670  N N   . VAL A 1 86  ? -52.376 -2.502  164.632 1.00 117.50 ? 86  VAL A N   1 
ATOM 671  C CA  . VAL A 1 86  ? -52.911 -3.359  163.573 1.00 117.50 ? 86  VAL A CA  1 
ATOM 672  C C   . VAL A 1 86  ? -54.006 -2.638  162.787 1.00 117.50 ? 86  VAL A C   1 
ATOM 673  O O   . VAL A 1 86  ? -54.019 -2.648  161.547 1.00 117.50 ? 86  VAL A O   1 
ATOM 674  C CB  . VAL A 1 86  ? -53.422 -4.682  164.173 1.00 117.50 ? 86  VAL A CB  1 
ATOM 675  C CG1 . VAL A 1 86  ? -54.158 -5.506  163.128 1.00 117.50 ? 86  VAL A CG1 1 
ATOM 676  C CG2 . VAL A 1 86  ? -52.265 -5.480  164.755 1.00 117.50 ? 86  VAL A CG2 1 
ATOM 677  N N   . SER A 1 87  ? -54.950 -2.016  163.493 1.00 119.25 ? 87  SER A N   1 
ATOM 678  C CA  . SER A 1 87  ? -56.032 -1.304  162.820 1.00 119.25 ? 87  SER A CA  1 
ATOM 679  C C   . SER A 1 87  ? -55.515 -0.168  161.945 1.00 119.25 ? 87  SER A C   1 
ATOM 680  O O   . SER A 1 87  ? -55.959 -0.005  160.800 1.00 119.25 ? 87  SER A O   1 
ATOM 681  C CB  . SER A 1 87  ? -57.027 -0.756  163.845 1.00 30.00  ? 87  SER A CB  1 
ATOM 682  O OG  . SER A 1 87  ? -56.418 0.217   164.675 1.00 30.00  ? 87  SER A OG  1 
ATOM 683  N N   . TYR A 1 88  ? -54.523 0.581   162.433 1.00 111.34 ? 88  TYR A N   1 
ATOM 684  C CA  . TYR A 1 88  ? -53.962 1.665   161.633 1.00 111.34 ? 88  TYR A CA  1 
ATOM 685  C C   . TYR A 1 88  ? -53.261 1.148   160.386 1.00 111.34 ? 88  TYR A C   1 
ATOM 686  O O   . TYR A 1 88  ? -53.507 1.640   159.276 1.00 111.34 ? 88  TYR A O   1 
ATOM 687  C CB  . TYR A 1 88  ? -52.990 2.490   162.480 1.00 111.34 ? 88  TYR A CB  1 
ATOM 688  C CG  . TYR A 1 88  ? -52.247 3.540   161.683 1.00 111.34 ? 88  TYR A CG  1 
ATOM 689  C CD1 . TYR A 1 88  ? -51.094 3.214   160.979 1.00 111.34 ? 88  TYR A CD1 1 
ATOM 690  C CD2 . TYR A 1 88  ? -52.675 4.858   161.657 1.00 111.34 ? 88  TYR A CD2 1 
ATOM 691  C CE1 . TYR A 1 88  ? -50.394 4.167   160.273 1.00 111.34 ? 88  TYR A CE1 1 
ATOM 692  C CE2 . TYR A 1 88  ? -51.995 5.815   160.927 1.00 111.34 ? 88  TYR A CE2 1 
ATOM 693  C CZ  . TYR A 1 88  ? -50.852 5.463   160.241 1.00 111.34 ? 88  TYR A CZ  1 
ATOM 694  O OH  . TYR A 1 88  ? -50.162 6.410   159.521 1.00 111.34 ? 88  TYR A OH  1 
ATOM 695  N N   . VAL A 1 89  ? -52.413 0.132   160.538 1.00 111.14 ? 89  VAL A N   1 
ATOM 696  C CA  . VAL A 1 89  ? -51.703 -0.399  159.380 1.00 111.14 ? 89  VAL A CA  1 
ATOM 697  C C   . VAL A 1 89  ? -52.686 -0.891  158.325 1.00 111.14 ? 89  VAL A C   1 
ATOM 698  O O   . VAL A 1 89  ? -52.671 -0.419  157.175 1.00 111.14 ? 89  VAL A O   1 
ATOM 699  C CB  . VAL A 1 89  ? -50.699 -1.492  159.805 1.00 111.14 ? 89  VAL A CB  1 
ATOM 700  C CG1 . VAL A 1 89  ? -51.383 -2.712  160.391 1.00 111.14 ? 89  VAL A CG1 1 
ATOM 701  C CG2 . VAL A 1 89  ? -49.823 -1.908  158.638 1.00 111.14 ? 89  VAL A CG2 1 
ATOM 702  N N   . ASN A 1 90  ? -53.661 -1.704  158.739 1.00 110.17 ? 90  ASN A N   1 
ATOM 703  C CA  . ASN A 1 90  ? -54.593 -2.275  157.774 1.00 110.17 ? 90  ASN A CA  1 
ATOM 704  C C   . ASN A 1 90  ? -55.408 -1.195  157.082 1.00 110.17 ? 90  ASN A C   1 
ATOM 705  O O   . ASN A 1 90  ? -55.365 -1.081  155.854 1.00 110.17 ? 90  ASN A O   1 
ATOM 706  C CB  . ASN A 1 90  ? -55.519 -3.277  158.466 1.00 110.17 ? 90  ASN A CB  1 
ATOM 707  C CG  . ASN A 1 90  ? -54.795 -4.533  158.910 1.00 110.17 ? 90  ASN A CG  1 
ATOM 708  O OD1 . ASN A 1 90  ? -54.591 -4.757  160.102 1.00 110.17 ? 90  ASN A OD1 1 
ATOM 709  N ND2 . ASN A 1 90  ? -54.406 -5.363  157.949 1.00 110.17 ? 90  ASN A ND2 1 
ATOM 710  N N   . THR A 1 91  ? -55.958 -0.252  157.838 1.00 110.00 ? 91  THR A N   1 
ATOM 711  C CA  . THR A 1 91  ? -56.871 0.704   157.223 1.00 110.00 ? 91  THR A CA  1 
ATOM 712  C C   . THR A 1 91  ? -56.122 1.693   156.337 1.00 110.00 ? 91  THR A C   1 
ATOM 713  O O   . THR A 1 91  ? -56.381 1.776   155.122 1.00 110.00 ? 91  THR A O   1 
ATOM 714  C CB  . THR A 1 91  ? -57.660 1.440   158.306 1.00 110.00 ? 91  THR A CB  1 
ATOM 715  O OG1 . THR A 1 91  ? -58.225 0.488   159.216 1.00 110.00 ? 91  THR A OG1 1 
ATOM 716  C CG2 . THR A 1 91  ? -58.773 2.272   157.692 1.00 110.00 ? 91  THR A CG2 1 
ATOM 717  N N   . ASN A 1 92  ? -55.099 2.353   156.880 1.00 107.19 ? 92  ASN A N   1 
ATOM 718  C CA  . ASN A 1 92  ? -54.467 3.426   156.128 1.00 107.19 ? 92  ASN A CA  1 
ATOM 719  C C   . ASN A 1 92  ? -53.654 2.887   154.957 1.00 107.19 ? 92  ASN A C   1 
ATOM 720  O O   . ASN A 1 92  ? -53.831 3.349   153.823 1.00 107.19 ? 92  ASN A O   1 
ATOM 721  C CB  . ASN A 1 92  ? -53.590 4.258   157.061 1.00 107.19 ? 92  ASN A CB  1 
ATOM 722  C CG  . ASN A 1 92  ? -54.393 4.938   158.153 1.00 107.19 ? 92  ASN A CG  1 
ATOM 723  O OD1 . ASN A 1 92  ? -55.109 4.284   158.911 1.00 107.19 ? 92  ASN A OD1 1 
ATOM 724  N ND2 . ASN A 1 92  ? -54.286 6.258   158.231 1.00 107.19 ? 92  ASN A ND2 1 
ATOM 725  N N   . MET A 1 93  ? -52.756 1.922   155.176 1.00 106.91 ? 93  MET A N   1 
ATOM 726  C CA  . MET A 1 93  ? -51.981 1.472   154.021 1.00 106.91 ? 93  MET A CA  1 
ATOM 727  C C   . MET A 1 93  ? -52.817 0.626   153.062 1.00 106.91 ? 93  MET A C   1 
ATOM 728  O O   . MET A 1 93  ? -52.581 0.666   151.846 1.00 106.91 ? 93  MET A O   1 
ATOM 729  C CB  . MET A 1 93  ? -50.682 0.775   154.430 1.00 106.91 ? 93  MET A CB  1 
ATOM 730  C CG  . MET A 1 93  ? -49.601 1.787   154.851 1.00 106.91 ? 93  MET A CG  1 
ATOM 731  S SD  . MET A 1 93  ? -49.795 2.594   156.437 1.00 106.91 ? 93  MET A SD  1 
ATOM 732  C CE  . MET A 1 93  ? -49.398 1.213   157.483 1.00 106.91 ? 93  MET A CE  1 
ATOM 733  N N   . GLY A 1 94  ? -53.759 -0.179  153.565 1.00 100.14 ? 94  GLY A N   1 
ATOM 734  C CA  . GLY A 1 94  ? -54.633 -0.906  152.668 1.00 100.14 ? 94  GLY A CA  1 
ATOM 735  C C   . GLY A 1 94  ? -55.416 -0.026  151.709 1.00 100.14 ? 94  GLY A C   1 
ATOM 736  O O   . GLY A 1 94  ? -55.634 -0.407  150.558 1.00 100.14 ? 94  GLY A O   1 
ATOM 737  N N   . LEU A 1 95  ? -55.862 1.155   152.148 1.00 96.70  ? 95  LEU A N   1 
ATOM 738  C CA  . LEU A 1 95  ? -56.527 2.032   151.179 1.00 96.70  ? 95  LEU A CA  1 
ATOM 739  C C   . LEU A 1 95  ? -55.615 2.417   150.006 1.00 96.70  ? 95  LEU A C   1 
ATOM 740  O O   . LEU A 1 95  ? -56.013 2.324   148.831 1.00 96.70  ? 95  LEU A O   1 
ATOM 741  C CB  . LEU A 1 95  ? -57.034 3.286   151.892 1.00 96.70  ? 95  LEU A CB  1 
ATOM 742  C CG  . LEU A 1 95  ? -57.658 4.376   151.015 1.00 96.70  ? 95  LEU A CG  1 
ATOM 743  C CD1 . LEU A 1 95  ? -58.870 3.853   150.266 1.00 96.70  ? 95  LEU A CD1 1 
ATOM 744  C CD2 . LEU A 1 95  ? -58.034 5.578   151.862 1.00 96.70  ? 95  LEU A CD2 1 
ATOM 745  N N   . LYS A 1 96  ? -54.375 2.819   150.299 1.00 96.62  ? 96  LYS A N   1 
ATOM 746  C CA  . LYS A 1 96  ? -53.440 3.191   149.236 1.00 96.62  ? 96  LYS A CA  1 
ATOM 747  C C   . LYS A 1 96  ? -53.085 2.017   148.326 1.00 96.62  ? 96  LYS A C   1 
ATOM 748  O O   . LYS A 1 96  ? -53.044 2.161   147.094 1.00 96.62  ? 96  LYS A O   1 
ATOM 749  C CB  . LYS A 1 96  ? -52.176 3.791   149.849 1.00 96.62  ? 96  LYS A CB  1 
ATOM 750  C CG  . LYS A 1 96  ? -52.396 5.157   150.483 1.00 96.62  ? 96  LYS A CG  1 
ATOM 751  C CD  . LYS A 1 96  ? -51.087 5.777   150.939 1.00 96.62  ? 96  LYS A CD  1 
ATOM 752  C CE  . LYS A 1 96  ? -51.301 7.147   151.562 1.00 96.62  ? 96  LYS A CE  1 
ATOM 753  N NZ  . LYS A 1 96  ? -51.765 8.156   150.572 1.00 96.62  ? 96  LYS A NZ  1 
ATOM 754  N N   . PHE A 1 97  ? -52.871 0.847   148.937 1.00 94.26  ? 97  PHE A N   1 
ATOM 755  C CA  . PHE A 1 97  ? -52.553 -0.377  148.156 1.00 94.26  ? 97  PHE A CA  1 
ATOM 756  C C   . PHE A 1 97  ? -53.735 -0.707  147.239 1.00 94.26  ? 97  PHE A C   1 
ATOM 757  O O   . PHE A 1 97  ? -53.499 -1.059  146.067 1.00 94.26  ? 97  PHE A O   1 
ATOM 758  C CB  . PHE A 1 97  ? -52.235 -1.528  149.113 1.00 30.00  ? 97  PHE A CB  1 
ATOM 759  C CG  . PHE A 1 97  ? -51.606 -2.743  148.478 1.00 30.00  ? 97  PHE A CG  1 
ATOM 760  C CD1 . PHE A 1 97  ? -50.564 -2.613  147.572 1.00 30.00  ? 97  PHE A CD1 1 
ATOM 761  C CD2 . PHE A 1 97  ? -52.036 -4.018  148.807 1.00 30.00  ? 97  PHE A CD2 1 
ATOM 762  C CE1 . PHE A 1 97  ? -49.981 -3.731  146.998 1.00 30.00  ? 97  PHE A CE1 1 
ATOM 763  C CE2 . PHE A 1 97  ? -51.451 -5.135  148.232 1.00 30.00  ? 97  PHE A CE2 1 
ATOM 764  C CZ  . PHE A 1 97  ? -50.424 -4.990  147.328 1.00 30.00  ? 97  PHE A CZ  1 
ATOM 765  N N   . ARG A 1 98  ? -54.963 -0.591  147.756 1.00 92.48  ? 98  ARG A N   1 
ATOM 766  C CA  . ARG A 1 98  ? -56.143 -0.871  146.951 1.00 92.48  ? 98  ARG A CA  1 
ATOM 767  C C   . ARG A 1 98  ? -56.226 0.054   145.745 1.00 92.48  ? 98  ARG A C   1 
ATOM 768  O O   . ARG A 1 98  ? -56.457 -0.405  144.619 1.00 92.48  ? 98  ARG A O   1 
ATOM 769  C CB  . ARG A 1 98  ? -57.403 -0.743  147.809 1.00 92.48  ? 98  ARG A CB  1 
ATOM 770  C CG  . ARG A 1 98  ? -57.595 -1.894  148.775 1.00 92.48  ? 98  ARG A CG  1 
ATOM 771  C CD  . ARG A 1 98  ? -58.507 -1.539  149.936 1.00 92.48  ? 98  ARG A CD  1 
ATOM 772  N NE  . ARG A 1 98  ? -59.816 -1.070  149.494 1.00 92.48  ? 98  ARG A NE  1 
ATOM 773  C CZ  . ARG A 1 98  ? -60.497 -0.081  150.059 1.00 92.48  ? 98  ARG A CZ  1 
ATOM 774  N NH1 . ARG A 1 98  ? -60.061 0.528   151.151 1.00 92.48  ? 98  ARG A NH1 1 
ATOM 775  N NH2 . ARG A 1 98  ? -61.664 0.283   149.537 1.00 92.48  ? 98  ARG A NH2 1 
ATOM 776  N N   . GLN A 1 99  ? -55.984 1.353   145.943 1.00 92.76  ? 99  GLN A N   1 
ATOM 777  C CA  . GLN A 1 99  ? -55.966 2.263   144.796 1.00 92.76  ? 99  GLN A CA  1 
ATOM 778  C C   . GLN A 1 99  ? -54.905 1.877   143.766 1.00 92.76  ? 99  GLN A C   1 
ATOM 779  O O   . GLN A 1 99  ? -55.190 1.802   142.561 1.00 92.76  ? 99  GLN A O   1 
ATOM 780  C CB  . GLN A 1 99  ? -55.717 3.696   145.265 1.00 92.76  ? 99  GLN A CB  1 
ATOM 781  C CG  . GLN A 1 99  ? -56.785 4.268   146.168 1.00 92.76  ? 99  GLN A CG  1 
ATOM 782  C CD  . GLN A 1 99  ? -56.555 5.738   146.465 1.00 92.76  ? 99  GLN A CD  1 
ATOM 783  O OE1 . GLN A 1 99  ? -56.357 6.544   145.555 1.00 92.76  ? 99  GLN A OE1 1 
ATOM 784  N NE2 . GLN A 1 99  ? -56.562 6.091   147.745 1.00 92.76  ? 99  GLN A NE2 1 
ATOM 785  N N   . LEU A 1 100 ? -53.688 1.577   144.223 1.00 91.55  ? 100 LEU A N   1 
ATOM 786  C CA  . LEU A 1 100 ? -52.607 1.304   143.274 1.00 91.55  ? 100 LEU A CA  1 
ATOM 787  C C   . LEU A 1 100 ? -52.844 0.005   142.509 1.00 91.55  ? 100 LEU A C   1 
ATOM 788  O O   . LEU A 1 100 ? -52.675 -0.052  141.279 1.00 91.55  ? 100 LEU A O   1 
ATOM 789  C CB  . LEU A 1 100 ? -51.269 1.259   144.010 1.00 91.55  ? 100 LEU A CB  1 
ATOM 790  C CG  . LEU A 1 100 ? -50.025 1.078   143.136 1.00 91.55  ? 100 LEU A CG  1 
ATOM 791  C CD1 . LEU A 1 100 ? -49.846 2.254   142.186 1.00 91.55  ? 100 LEU A CD1 1 
ATOM 792  C CD2 . LEU A 1 100 ? -48.796 0.904   144.008 1.00 91.55  ? 100 LEU A CD2 1 
ATOM 793  N N   . LEU A 1 101 ? -53.236 -1.050  143.223 1.00 92.92  ? 101 LEU A N   1 
ATOM 794  C CA  . LEU A 1 101 ? -53.555 -2.315  142.577 1.00 92.92  ? 101 LEU A CA  1 
ATOM 795  C C   . LEU A 1 101 ? -54.683 -2.148  141.573 1.00 92.92  ? 101 LEU A C   1 
ATOM 796  O O   . LEU A 1 101 ? -54.609 -2.667  140.455 1.00 92.92  ? 101 LEU A O   1 
ATOM 797  C CB  . LEU A 1 101 ? -53.931 -3.356  143.632 1.00 92.92  ? 101 LEU A CB  1 
ATOM 798  C CG  . LEU A 1 101 ? -52.799 -3.952  144.471 1.00 92.92  ? 101 LEU A CG  1 
ATOM 799  C CD1 . LEU A 1 101 ? -53.352 -4.979  145.444 1.00 92.92  ? 101 LEU A CD1 1 
ATOM 800  C CD2 . LEU A 1 101 ? -51.728 -4.572  143.601 1.00 92.92  ? 101 LEU A CD2 1 
ATOM 801  N N   . TRP A 1 102 ? -55.760 -1.460  141.963 1.00 86.59  ? 102 TRP A N   1 
ATOM 802  C CA  . TRP A 1 102 ? -56.868 -1.301  141.031 1.00 86.59  ? 102 TRP A CA  1 
ATOM 803  C C   . TRP A 1 102 ? -56.408 -0.601  139.763 1.00 86.59  ? 102 TRP A C   1 
ATOM 804  O O   . TRP A 1 102 ? -56.726 -1.039  138.651 1.00 86.59  ? 102 TRP A O   1 
ATOM 805  C CB  . TRP A 1 102 ? -58.004 -0.513  141.676 1.00 86.59  ? 102 TRP A CB  1 
ATOM 806  C CG  . TRP A 1 102 ? -59.126 -0.238  140.721 1.00 86.59  ? 102 TRP A CG  1 
ATOM 807  C CD1 . TRP A 1 102 ? -60.199 -1.040  140.467 1.00 86.59  ? 102 TRP A CD1 1 
ATOM 808  C CD2 . TRP A 1 102 ? -59.277 0.912   139.880 1.00 86.59  ? 102 TRP A CD2 1 
ATOM 809  N NE1 . TRP A 1 102 ? -61.025 -0.446  139.545 1.00 86.59  ? 102 TRP A NE1 1 
ATOM 810  C CE2 . TRP A 1 102 ? -60.468 0.740   139.149 1.00 86.59  ? 102 TRP A CE2 1 
ATOM 811  C CE3 . TRP A 1 102 ? -58.513 2.062   139.663 1.00 86.59  ? 102 TRP A CE3 1 
ATOM 812  C CZ2 . TRP A 1 102 ? -60.919 1.680   138.227 1.00 86.59  ? 102 TRP A CZ2 1 
ATOM 813  C CZ3 . TRP A 1 102 ? -58.967 2.998   138.755 1.00 86.59  ? 102 TRP A CZ3 1 
ATOM 814  C CH2 . TRP A 1 102 ? -60.143 2.788   138.027 1.00 86.59  ? 102 TRP A CH2 1 
ATOM 815  N N   . PHE A 1 103 ? -55.604 0.454   139.909 1.00 87.94  ? 103 PHE A N   1 
ATOM 816  C CA  . PHE A 1 103 ? -55.145 1.190   138.736 1.00 87.94  ? 103 PHE A CA  1 
ATOM 817  C C   . PHE A 1 103 ? -54.313 0.320   137.802 1.00 87.94  ? 103 PHE A C   1 
ATOM 818  O O   . PHE A 1 103 ? -54.574 0.266   136.595 1.00 87.94  ? 103 PHE A O   1 
ATOM 819  C CB  . PHE A 1 103 ? -54.343 2.418   139.161 1.00 87.94  ? 103 PHE A CB  1 
ATOM 820  C CG  . PHE A 1 103 ? -53.848 3.239   138.004 1.00 87.94  ? 103 PHE A CG  1 
ATOM 821  C CD1 . PHE A 1 103 ? -54.688 4.127   137.359 1.00 87.94  ? 103 PHE A CD1 1 
ATOM 822  C CD2 . PHE A 1 103 ? -52.550 3.102   137.546 1.00 87.94  ? 103 PHE A CD2 1 
ATOM 823  C CE1 . PHE A 1 103 ? -54.239 4.873   136.289 1.00 87.94  ? 103 PHE A CE1 1 
ATOM 824  C CE2 . PHE A 1 103 ? -52.099 3.840   136.471 1.00 87.94  ? 103 PHE A CE2 1 
ATOM 825  C CZ  . PHE A 1 103 ? -52.944 4.727   135.844 1.00 87.94  ? 103 PHE A CZ  1 
ATOM 826  N N   . HIS A 1 104 ? -53.314 -0.386  138.337 1.00 90.76  ? 104 HIS A N   1 
ATOM 827  C CA  . HIS A 1 104 ? -52.463 -1.182  137.451 1.00 90.76  ? 104 HIS A CA  1 
ATOM 828  C C   . HIS A 1 104 ? -53.183 -2.398  136.867 1.00 90.76  ? 104 HIS A C   1 
ATOM 829  O O   . HIS A 1 104 ? -53.005 -2.711  135.682 1.00 90.76  ? 104 HIS A O   1 
ATOM 830  C CB  . HIS A 1 104 ? -51.193 -1.608  138.184 1.00 90.76  ? 104 HIS A CB  1 
ATOM 831  C CG  . HIS A 1 104 ? -50.232 -0.484  138.411 1.00 90.76  ? 104 HIS A CG  1 
ATOM 832  N ND1 . HIS A 1 104 ? -49.641 0.205   137.374 1.00 90.76  ? 104 HIS A ND1 1 
ATOM 833  C CD2 . HIS A 1 104 ? -49.763 0.077   139.550 1.00 90.76  ? 104 HIS A CD2 1 
ATOM 834  C CE1 . HIS A 1 104 ? -48.844 1.137   137.864 1.00 90.76  ? 104 HIS A CE1 1 
ATOM 835  N NE2 . HIS A 1 104 ? -48.911 1.090   139.182 1.00 90.76  ? 104 HIS A NE2 1 
ATOM 836  N N   . ILE A 1 105 ? -53.988 -3.101  137.663 1.00 91.32  ? 105 ILE A N   1 
ATOM 837  C CA  . ILE A 1 105 ? -54.761 -4.219  137.124 1.00 91.32  ? 105 ILE A CA  1 
ATOM 838  C C   . ILE A 1 105 ? -55.690 -3.755  136.007 1.00 91.32  ? 105 ILE A C   1 
ATOM 839  O O   . ILE A 1 105 ? -55.790 -4.400  134.955 1.00 91.32  ? 105 ILE A O   1 
ATOM 840  C CB  . ILE A 1 105 ? -55.532 -4.924  138.256 1.00 91.32  ? 105 ILE A CB  1 
ATOM 841  C CG1 . ILE A 1 105 ? -54.551 -5.642  139.182 1.00 91.32  ? 105 ILE A CG1 1 
ATOM 842  C CG2 . ILE A 1 105 ? -56.537 -5.928  137.697 1.00 91.32  ? 105 ILE A CG2 1 
ATOM 843  C CD1 . ILE A 1 105 ? -55.181 -6.190  140.443 1.00 91.32  ? 105 ILE A CD1 1 
ATOM 844  N N   . SER A 1 106 ? -56.379 -2.629  136.209 1.00 89.78  ? 106 SER A N   1 
ATOM 845  C CA  . SER A 1 106 ? -57.264 -2.107  135.174 1.00 89.78  ? 106 SER A CA  1 
ATOM 846  C C   . SER A 1 106 ? -56.501 -1.686  133.926 1.00 89.78  ? 106 SER A C   1 
ATOM 847  O O   . SER A 1 106 ? -56.941 -1.953  132.803 1.00 89.78  ? 106 SER A O   1 
ATOM 848  C CB  . SER A 1 106 ? -58.068 -0.930  135.724 1.00 89.78  ? 106 SER A CB  1 
ATOM 849  O OG  . SER A 1 106 ? -58.744 -1.290  136.915 1.00 89.78  ? 106 SER A OG  1 
ATOM 850  N N   . CYS A 1 107 ? -55.357 -1.019  134.092 1.00 92.41  ? 107 CYS A N   1 
ATOM 851  C CA  . CYS A 1 107 ? -54.548 -0.657  132.933 1.00 92.41  ? 107 CYS A CA  1 
ATOM 852  C C   . CYS A 1 107 ? -54.081 -1.876  132.146 1.00 92.41  ? 107 CYS A C   1 
ATOM 853  O O   . CYS A 1 107 ? -54.091 -1.859  130.910 1.00 92.41  ? 107 CYS A O   1 
ATOM 854  C CB  . CYS A 1 107 ? -53.346 0.176   133.376 1.00 92.41  ? 107 CYS A CB  1 
ATOM 855  S SG  . CYS A 1 107 ? -53.742 1.888   133.786 1.00 92.41  ? 107 CYS A SG  1 
ATOM 856  N N   . LEU A 1 108 ? -53.671 -2.946  132.829 1.00 91.45  ? 108 LEU A N   1 
ATOM 857  C CA  . LEU A 1 108 ? -53.320 -4.163  132.098 1.00 91.45  ? 108 LEU A CA  1 
ATOM 858  C C   . LEU A 1 108 ? -54.519 -4.792  131.398 1.00 91.45  ? 108 LEU A C   1 
ATOM 859  O O   . LEU A 1 108 ? -54.408 -5.228  130.247 1.00 91.45  ? 108 LEU A O   1 
ATOM 860  C CB  . LEU A 1 108 ? -52.679 -5.182  133.041 1.00 91.45  ? 108 LEU A CB  1 
ATOM 861  C CG  . LEU A 1 108 ? -51.247 -4.914  133.506 1.00 91.45  ? 108 LEU A CG  1 
ATOM 862  C CD1 . LEU A 1 108 ? -50.842 -5.929  134.558 1.00 91.45  ? 108 LEU A CD1 1 
ATOM 863  C CD2 . LEU A 1 108 ? -50.284 -4.956  132.332 1.00 91.45  ? 108 LEU A CD2 1 
ATOM 864  N N   . THR A 1 109 ? -55.673 -4.855  132.065 1.00 91.52  ? 109 THR A N   1 
ATOM 865  C CA  . THR A 1 109 ? -56.809 -5.571  131.487 1.00 91.52  ? 109 THR A CA  1 
ATOM 866  C C   . THR A 1 109 ? -57.460 -4.812  130.333 1.00 91.52  ? 109 THR A C   1 
ATOM 867  O O   . THR A 1 109 ? -57.733 -5.392  129.276 1.00 91.52  ? 109 THR A O   1 
ATOM 868  C CB  . THR A 1 109 ? -57.841 -5.868  132.574 1.00 91.52  ? 109 THR A CB  1 
ATOM 869  O OG1 . THR A 1 109 ? -57.195 -6.486  133.693 1.00 91.52  ? 109 THR A OG1 1 
ATOM 870  C CG2 . THR A 1 109 ? -58.921 -6.796  132.043 1.00 91.52  ? 109 THR A CG2 1 
ATOM 871  N N   . PHE A 1 110 ? -57.720 -3.515  130.513 1.00 93.57  ? 110 PHE A N   1 
ATOM 872  C CA  . PHE A 1 110 ? -58.449 -2.723  129.529 1.00 93.57  ? 110 PHE A CA  1 
ATOM 873  C C   . PHE A 1 110 ? -57.602 -1.746  128.723 1.00 93.57  ? 110 PHE A C   1 
ATOM 874  O O   . PHE A 1 110 ? -58.095 -1.220  127.719 1.00 93.57  ? 110 PHE A O   1 
ATOM 875  C CB  . PHE A 1 110 ? -59.571 -1.944  130.229 1.00 93.57  ? 110 PHE A CB  1 
ATOM 876  C CG  . PHE A 1 110 ? -60.560 -2.824  130.937 1.00 93.57  ? 110 PHE A CG  1 
ATOM 877  C CD1 . PHE A 1 110 ? -61.542 -3.494  130.231 1.00 93.57  ? 110 PHE A CD1 1 
ATOM 878  C CD2 . PHE A 1 110 ? -60.511 -2.975  132.310 1.00 93.57  ? 110 PHE A CD2 1 
ATOM 879  C CE1 . PHE A 1 110 ? -62.453 -4.300  130.881 1.00 93.57  ? 110 PHE A CE1 1 
ATOM 880  C CE2 . PHE A 1 110 ? -61.423 -3.778  132.966 1.00 93.57  ? 110 PHE A CE2 1 
ATOM 881  C CZ  . PHE A 1 110 ? -62.391 -4.443  132.250 1.00 93.57  ? 110 PHE A CZ  1 
ATOM 882  N N   . GLY A 1 111 ? -56.359 -1.486  129.115 1.00 95.49  ? 111 GLY A N   1 
ATOM 883  C CA  . GLY A 1 111 ? -55.571 -0.466  128.447 1.00 95.49  ? 111 GLY A CA  1 
ATOM 884  C C   . GLY A 1 111 ? -55.730 0.935   129.006 1.00 95.49  ? 111 GLY A C   1 
ATOM 885  O O   . GLY A 1 111 ? -56.815 1.349   129.422 1.00 95.49  ? 111 GLY A O   1 
ATOM 886  N N   . ARG A 1 112 ? -54.608 1.655   129.108 1.00 98.70  ? 112 ARG A N   1 
ATOM 887  C CA  . ARG A 1 112 ? -54.621 3.002   129.744 1.00 98.70  ? 112 ARG A CA  1 
ATOM 888  C C   . ARG A 1 112 ? -55.785 3.850   129.220 1.00 98.70  ? 112 ARG A C   1 
ATOM 889  O O   . ARG A 1 112 ? -56.528 4.398   130.057 1.00 98.70  ? 112 ARG A O   1 
ATOM 890  C CB  . ARG A 1 112 ? -53.291 3.716   129.488 1.00 98.70  ? 112 ARG A CB  1 
ATOM 891  C CG  . ARG A 1 112 ? -53.207 5.109   130.096 1.00 98.70  ? 112 ARG A CG  1 
ATOM 892  C CD  . ARG A 1 112 ? -51.946 5.846   129.687 1.00 98.70  ? 112 ARG A CD  1 
ATOM 893  N NE  . ARG A 1 112 ? -51.842 6.006   128.243 1.00 98.70  ? 112 ARG A NE  1 
ATOM 894  C CZ  . ARG A 1 112 ? -51.182 5.182   127.438 1.00 98.70  ? 112 ARG A CZ  1 
ATOM 895  N NH1 . ARG A 1 112 ? -50.551 4.132   127.936 1.00 98.70  ? 112 ARG A NH1 1 
ATOM 896  N NH2 . ARG A 1 112 ? -51.149 5.413   126.138 1.00 98.70  ? 112 ARG A NH2 1 
ATOM 897  N N   . GLU A 1 113 ? -55.926 3.963   127.898 1.00 98.51  ? 113 GLU A N   1 
ATOM 898  C CA  . GLU A 1 113 ? -56.973 4.853   127.328 1.00 98.51  ? 113 GLU A CA  1 
ATOM 899  C C   . GLU A 1 113 ? -58.341 4.459   127.896 1.00 98.51  ? 113 GLU A C   1 
ATOM 900  O O   . GLU A 1 113 ? -59.042 5.355   128.400 1.00 98.51  ? 113 GLU A O   1 
ATOM 901  C CB  . GLU A 1 113 ? -56.959 4.772   125.802 1.00 98.51  ? 113 GLU A CB  1 
ATOM 902  C CG  . GLU A 1 113 ? -55.575 4.963   125.207 1.00 98.51  ? 113 GLU A CG  1 
ATOM 903  C CD  . GLU A 1 113 ? -54.884 6.259   125.595 1.00 98.51  ? 113 GLU A CD  1 
ATOM 904  O OE1 . GLU A 1 113 ? -55.584 7.198   126.023 1.00 98.51  ? 113 GLU A OE1 1 
ATOM 905  O OE2 . GLU A 1 113 ? -53.645 6.323   125.475 1.00 98.51  ? 113 GLU A OE2 1 
ATOM 906  N N   . THR A 1 114 ? -58.685 3.169   127.843 1.00 93.21  ? 114 THR A N   1 
ATOM 907  C CA  . THR A 1 114 ? -60.019 2.713   128.313 1.00 93.21  ? 114 THR A CA  1 
ATOM 908  C C   . THR A 1 114 ? -60.211 3.124   129.776 1.00 93.21  ? 114 THR A C   1 
ATOM 909  O O   . THR A 1 114 ? -61.256 3.726   130.083 1.00 93.21  ? 114 THR A O   1 
ATOM 910  C CB  . THR A 1 114 ? -60.173 1.196   128.154 1.00 93.21  ? 114 THR A CB  1 
ATOM 911  O OG1 . THR A 1 114 ? -59.959 0.867   126.782 1.00 93.21  ? 114 THR A OG1 1 
ATOM 912  C CG2 . THR A 1 114 ? -61.529 0.693   128.599 1.00 93.21  ? 114 THR A CG2 1 
ATOM 913  N N   . VAL A 1 115 ? -59.228 2.828   130.631 1.00 91.93  ? 115 VAL A N   1 
ATOM 914  C CA  . VAL A 1 115 ? -59.339 3.144   132.086 1.00 91.93  ? 115 VAL A CA  1 
ATOM 915  C C   . VAL A 1 115 ? -59.567 4.650   132.257 1.00 91.93  ? 115 VAL A C   1 
ATOM 916  O O   . VAL A 1 115 ? -60.472 5.019   133.022 1.00 91.93  ? 115 VAL A O   1 
ATOM 917  C CB  . VAL A 1 115 ? -58.087 2.677   132.853 1.00 91.93  ? 115 VAL A CB  1 
ATOM 918  C CG1 . VAL A 1 115 ? -58.211 2.934   134.347 1.00 91.93  ? 115 VAL A CG1 1 
ATOM 919  C CG2 . VAL A 1 115 ? -57.779 1.212   132.583 1.00 91.93  ? 115 VAL A CG2 1 
ATOM 920  N N   . ILE A 1 116 ? -58.633 5.478   131.746 1.00 94.37  ? 116 ILE A N   1 
ATOM 921  C CA  . ILE A 1 116 ? -58.581 6.965   131.968 1.00 94.37  ? 116 ILE A CA  1 
ATOM 922  C C   . ILE A 1 116 ? -59.814 7.713   131.468 1.00 94.37  ? 116 ILE A C   1 
ATOM 923  O O   . ILE A 1 116 ? -60.277 8.645   132.182 1.00 94.37  ? 116 ILE A O   1 
ATOM 924  C CB  . ILE A 1 116 ? -57.322 7.539   131.291 1.00 30.00  ? 116 ILE A CB  1 
ATOM 925  C CG1 . ILE A 1 116 ? -56.045 7.074   131.996 1.00 30.00  ? 116 ILE A CG1 1 
ATOM 926  C CG2 . ILE A 1 116 ? -57.400 9.054   131.204 1.00 30.00  ? 116 ILE A CG2 1 
ATOM 927  C CD1 . ILE A 1 116 ? -54.777 7.650   131.416 1.00 30.00  ? 116 ILE A CD1 1 
ATOM 928  N N   . GLU A 1 117 ? -60.260 7.433   130.251 1.00 95.39  ? 117 GLU A N   1 
ATOM 929  C CA  . GLU A 1 117 ? -61.521 8.030   129.765 1.00 95.39  ? 117 GLU A CA  1 
ATOM 930  C C   . GLU A 1 117 ? -62.584 7.638   130.785 1.00 95.39  ? 117 GLU A C   1 
ATOM 931  O O   . GLU A 1 117 ? -63.398 8.503   131.136 1.00 95.39  ? 117 GLU A O   1 
ATOM 932  C CB  . GLU A 1 117 ? -61.840 7.531   128.362 1.00 95.39  ? 117 GLU A CB  1 
ATOM 933  C CG  . GLU A 1 117 ? -60.801 7.934   127.335 1.00 95.39  ? 117 GLU A CG  1 
ATOM 934  C CD  . GLU A 1 117 ? -60.879 7.173   126.024 1.00 95.39  ? 117 GLU A CD  1 
ATOM 935  O OE1 . GLU A 1 117 ? -61.657 6.204   125.949 1.00 95.39  ? 117 GLU A OE1 1 
ATOM 936  O OE2 . GLU A 1 117 ? -60.158 7.550   125.082 1.00 95.39  ? 117 GLU A OE2 1 
ATOM 937  N N   . TYR A 1 118 ? -62.533 6.407   131.299 1.00 88.44  ? 118 TYR A N   1 
ATOM 938  C CA  . TYR A 1 118 ? -63.531 5.911   132.277 1.00 88.44  ? 118 TYR A CA  1 
ATOM 939  C C   . TYR A 1 118 ? -63.464 6.786   133.521 1.00 88.44  ? 118 TYR A C   1 
ATOM 940  O O   . TYR A 1 118 ? -64.512 7.190   133.980 1.00 88.44  ? 118 TYR A O   1 
ATOM 941  C CB  . TYR A 1 118 ? -63.343 4.438   132.642 1.00 88.44  ? 118 TYR A CB  1 
ATOM 942  C CG  . TYR A 1 118 ? -64.116 4.008   133.860 1.00 88.44  ? 118 TYR A CG  1 
ATOM 943  C CD1 . TYR A 1 118 ? -63.605 4.197   135.131 1.00 88.44  ? 118 TYR A CD1 1 
ATOM 944  C CD2 . TYR A 1 118 ? -65.369 3.429   133.743 1.00 88.44  ? 118 TYR A CD2 1 
ATOM 945  C CE1 . TYR A 1 118 ? -64.315 3.817   136.257 1.00 88.44  ? 118 TYR A CE1 1 
ATOM 946  C CE2 . TYR A 1 118 ? -66.090 3.042   134.858 1.00 88.44  ? 118 TYR A CE2 1 
ATOM 947  C CZ  . TYR A 1 118 ? -65.561 3.234   136.119 1.00 88.44  ? 118 TYR A CZ  1 
ATOM 948  O OH  . TYR A 1 118 ? -66.267 2.855   137.222 1.00 88.44  ? 118 TYR A OH  1 
ATOM 949  N N   . LEU A 1 119 ? -62.277 7.068   134.042 1.00 89.77  ? 119 LEU A N   1 
ATOM 950  C CA  . LEU A 1 119 ? -62.129 7.984   135.199 1.00 89.77  ? 119 LEU A CA  1 
ATOM 951  C C   . LEU A 1 119 ? -62.824 9.295   134.844 1.00 89.77  ? 119 LEU A C   1 
ATOM 952  O O   . LEU A 1 119 ? -63.849 9.614   135.498 1.00 89.77  ? 119 LEU A O   1 
ATOM 953  C CB  . LEU A 1 119 ? -60.647 8.210   135.506 1.00 89.77  ? 119 LEU A CB  1 
ATOM 954  C CG  . LEU A 1 119 ? -60.069 7.365   136.639 1.00 89.77  ? 119 LEU A CG  1 
ATOM 955  C CD1 . LEU A 1 119 ? -58.580 7.614   136.785 1.00 89.77  ? 119 LEU A CD1 1 
ATOM 956  C CD2 . LEU A 1 119 ? -60.781 7.644   137.953 1.00 89.77  ? 119 LEU A CD2 1 
ATOM 957  N N   . VAL A 1 120 ? -62.377 9.959   133.780 1.00 88.26  ? 120 VAL A N   1 
ATOM 958  C CA  . VAL A 1 120 ? -62.940 11.286  133.390 1.00 88.26  ? 120 VAL A CA  1 
ATOM 959  C C   . VAL A 1 120 ? -64.469 11.219  133.371 1.00 88.26  ? 120 VAL A C   1 
ATOM 960  O O   . VAL A 1 120 ? -65.068 12.186  133.846 1.00 88.26  ? 120 VAL A O   1 
ATOM 961  C CB  . VAL A 1 120 ? -62.402 11.746  132.024 1.00 88.26  ? 120 VAL A CB  1 
ATOM 962  C CG1 . VAL A 1 120 ? -63.227 12.886  131.450 1.00 88.26  ? 120 VAL A CG1 1 
ATOM 963  C CG2 . VAL A 1 120 ? -60.935 12.130  132.100 1.00 88.26  ? 120 VAL A CG2 1 
ATOM 964  N N   . SER A 1 121 ? -65.078 10.128  132.896 1.00 88.15  ? 121 SER A N   1 
ATOM 965  C CA  . SER A 1 121 ? -66.552 9.998   132.736 1.00 88.15  ? 121 SER A CA  1 
ATOM 966  C C   . SER A 1 121 ? -67.291 9.673   134.040 1.00 88.15  ? 121 SER A C   1 
ATOM 967  O O   . SER A 1 121 ? -68.347 10.269  134.251 1.00 88.15  ? 121 SER A O   1 
ATOM 968  C CB  . SER A 1 121 ? -66.857 8.964   131.701 1.00 88.15  ? 121 SER A CB  1 
ATOM 969  O OG  . SER A 1 121 ? -66.332 9.342   130.439 1.00 88.15  ? 121 SER A OG  1 
ATOM 970  N N   . PHE A 1 122 ? -66.838 8.702   134.833 1.00 88.33  ? 122 PHE A N   1 
ATOM 971  C CA  . PHE A 1 122 ? -67.501 8.308   136.104 1.00 88.33  ? 122 PHE A CA  1 
ATOM 972  C C   . PHE A 1 122 ? -67.620 9.594   136.884 1.00 88.33  ? 122 PHE A C   1 
ATOM 973  O O   . PHE A 1 122 ? -68.644 9.875   137.486 1.00 88.33  ? 122 PHE A O   1 
ATOM 974  C CB  . PHE A 1 122 ? -66.678 7.289   136.887 1.00 88.33  ? 122 PHE A CB  1 
ATOM 975  C CG  . PHE A 1 122 ? -67.113 7.120   138.319 1.00 88.33  ? 122 PHE A CG  1 
ATOM 976  C CD1 . PHE A 1 122 ? -66.665 7.986   139.301 1.00 88.33  ? 122 PHE A CD1 1 
ATOM 977  C CD2 . PHE A 1 122 ? -67.975 6.100   138.681 1.00 88.33  ? 122 PHE A CD2 1 
ATOM 978  C CE1 . PHE A 1 122 ? -67.068 7.833   140.617 1.00 88.33  ? 122 PHE A CE1 1 
ATOM 979  C CE2 . PHE A 1 122 ? -68.377 5.949   139.997 1.00 88.33  ? 122 PHE A CE2 1 
ATOM 980  C CZ  . PHE A 1 122 ? -67.922 6.815   140.963 1.00 88.33  ? 122 PHE A CZ  1 
ATOM 981  N N   . GLY A 1 123 ? -66.549 10.344  136.874 1.00 90.65  ? 123 GLY A N   1 
ATOM 982  C CA  . GLY A 1 123 ? -66.480 11.684  137.488 1.00 90.65  ? 123 GLY A CA  1 
ATOM 983  C C   . GLY A 1 123 ? -67.617 12.567  137.007 1.00 90.65  ? 123 GLY A C   1 
ATOM 984  O O   . GLY A 1 123 ? -68.275 13.206  137.855 1.00 90.65  ? 123 GLY A O   1 
ATOM 985  N N   . VAL A 1 124 ? -67.858 12.584  135.694 1.00 88.20  ? 124 VAL A N   1 
ATOM 986  C CA  . VAL A 1 124 ? -68.939 13.441  135.122 1.00 88.20  ? 124 VAL A CA  1 
ATOM 987  C C   . VAL A 1 124 ? -70.282 12.988  135.703 1.00 88.20  ? 124 VAL A C   1 
ATOM 988  O O   . VAL A 1 124 ? -71.097 13.861  136.053 1.00 88.20  ? 124 VAL A O   1 
ATOM 989  C CB  . VAL A 1 124 ? -68.946 13.380  133.583 1.00 88.20  ? 124 VAL A CB  1 
ATOM 990  C CG1 . VAL A 1 124 ? -70.088 14.191  132.992 1.00 88.20  ? 124 VAL A CG1 1 
ATOM 991  C CG2 . VAL A 1 124 ? -67.614 13.819  132.995 1.00 88.20  ? 124 VAL A CG2 1 
ATOM 992  N N   . TRP A 1 125 ? -70.493 11.674  135.811 1.00 89.62  ? 125 TRP A N   1 
ATOM 993  C CA  . TRP A 1 125 ? -71.784 11.127  136.309 1.00 89.62  ? 125 TRP A CA  1 
ATOM 994  C C   . TRP A 1 125 ? -71.972 11.480  137.788 1.00 89.62  ? 125 TRP A C   1 
ATOM 995  O O   . TRP A 1 125 ? -73.132 11.717  138.198 1.00 89.62  ? 125 TRP A O   1 
ATOM 996  C CB  . TRP A 1 125 ? -71.818 9.612   136.074 1.00 89.62  ? 125 TRP A CB  1 
ATOM 997  C CG  . TRP A 1 125 ? -72.935 8.898   136.769 1.00 89.62  ? 125 TRP A CG  1 
ATOM 998  C CD1 . TRP A 1 125 ? -74.216 8.742   136.325 1.00 89.62  ? 125 TRP A CD1 1 
ATOM 999  C CD2 . TRP A 1 125 ? -72.866 8.222   138.036 1.00 89.62  ? 125 TRP A CD2 1 
ATOM 1000 N NE1 . TRP A 1 125 ? -74.948 8.022   137.229 1.00 89.62  ? 125 TRP A NE1 1 
ATOM 1001 C CE2 . TRP A 1 125 ? -74.147 7.690   138.290 1.00 89.62  ? 125 TRP A CE2 1 
ATOM 1002 C CE3 . TRP A 1 125 ? -71.853 8.019   138.978 1.00 89.62  ? 125 TRP A CE3 1 
ATOM 1003 C CZ2 . TRP A 1 125 ? -74.438 6.969   139.446 1.00 89.62  ? 125 TRP A CZ2 1 
ATOM 1004 C CZ3 . TRP A 1 125 ? -72.140 7.306   140.122 1.00 89.62  ? 125 TRP A CZ3 1 
ATOM 1005 C CH2 . TRP A 1 125 ? -73.415 6.791   140.350 1.00 89.62  ? 125 TRP A CH2 1 
ATOM 1006 N N   . ILE A 1 126 ? -70.878 11.519  138.555 1.00 91.07  ? 126 ILE A N   1 
ATOM 1007 C CA  . ILE A 1 126 ? -70.980 11.771  140.023 1.00 91.07  ? 126 ILE A CA  1 
ATOM 1008 C C   . ILE A 1 126 ? -71.218 13.265  140.266 1.00 91.07  ? 126 ILE A C   1 
ATOM 1009 O O   . ILE A 1 126 ? -71.941 13.588  141.225 1.00 91.07  ? 126 ILE A O   1 
ATOM 1010 C CB  . ILE A 1 126 ? -69.733 11.244  140.766 1.00 91.07  ? 126 ILE A CB  1 
ATOM 1011 C CG1 . ILE A 1 126 ? -70.045 10.927  142.230 1.00 91.07  ? 126 ILE A CG1 1 
ATOM 1012 C CG2 . ILE A 1 126 ? -68.563 12.205  140.631 1.00 91.07  ? 126 ILE A CG2 1 
ATOM 1013 C CD1 . ILE A 1 126 ? -71.187 9.956   142.416 1.00 91.07  ? 126 ILE A CD1 1 
ATOM 1014 N N   . ARG A 1 127 ? -70.645 14.147  139.439 1.00 97.67  ? 127 ARG A N   1 
ATOM 1015 C CA  . ARG A 1 127 ? -70.956 15.566  139.630 1.00 97.67  ? 127 ARG A CA  1 
ATOM 1016 C C   . ARG A 1 127 ? -72.417 15.911  139.341 1.00 97.67  ? 127 ARG A C   1 
ATOM 1017 O O   . ARG A 1 127 ? -72.889 16.953  139.809 1.00 97.67  ? 127 ARG A O   1 
ATOM 1018 C CB  . ARG A 1 127 ? -70.057 16.458  138.797 1.00 97.67  ? 127 ARG A CB  1 
ATOM 1019 C CG  . ARG A 1 127 ? -68.608 16.293  139.242 1.00 97.67  ? 127 ARG A CG  1 
ATOM 1020 C CD  . ARG A 1 127 ? -67.703 17.140  138.353 1.00 97.67  ? 127 ARG A CD  1 
ATOM 1021 N NE  . ARG A 1 127 ? -67.680 16.616  136.969 1.00 97.67  ? 127 ARG A NE  1 
ATOM 1022 C CZ  . ARG A 1 127 ? -67.079 17.249  135.966 1.00 97.67  ? 127 ARG A CZ  1 
ATOM 1023 N NH1 . ARG A 1 127 ? -66.450 18.409  136.139 1.00 97.67  ? 127 ARG A NH1 1 
ATOM 1024 N NH2 . ARG A 1 127 ? -67.119 16.688  134.760 1.00 97.67  ? 127 ARG A NH2 1 
ATOM 1025 N N   . THR A 1 128 ? -73.142 15.081  138.598 1.00 93.20  ? 128 THR A N   1 
ATOM 1026 C CA  . THR A 1 128 ? -74.565 15.342  138.357 1.00 93.20  ? 128 THR A CA  1 
ATOM 1027 C C   . THR A 1 128 ? -75.381 15.267  139.649 1.00 93.20  ? 128 THR A C   1 
ATOM 1028 O O   . THR A 1 128 ? -75.206 14.331  140.438 1.00 93.20  ? 128 THR A O   1 
ATOM 1029 C CB  . THR A 1 128 ? -75.114 14.339  137.345 1.00 93.20  ? 128 THR A CB  1 
ATOM 1030 O OG1 . THR A 1 128 ? -74.384 14.447  136.117 1.00 93.20  ? 128 THR A OG1 1 
ATOM 1031 C CG2 . THR A 1 128 ? -76.588 14.600  137.077 1.00 93.20  ? 128 THR A CG2 1 
ATOM 1032 N N   . PRO A 1 129 ? -76.269 16.232  139.899 1.00 92.45  ? 129 PRO A N   1 
ATOM 1033 C CA  . PRO A 1 129 ? -77.072 16.201  141.120 1.00 92.45  ? 129 PRO A CA  1 
ATOM 1034 C C   . PRO A 1 129 ? -77.966 14.980  141.187 1.00 92.45  ? 129 PRO A C   1 
ATOM 1035 O O   . PRO A 1 129 ? -78.363 14.414  140.151 1.00 92.45  ? 129 PRO A O   1 
ATOM 1036 C CB  . PRO A 1 129 ? -77.899 17.492  141.028 1.00 92.45  ? 129 PRO A CB  1 
ATOM 1037 C CG  . PRO A 1 129 ? -77.064 18.402  140.235 1.00 92.45  ? 129 PRO A CG  1 
ATOM 1038 C CD  . PRO A 1 129 ? -76.434 17.514  139.194 1.00 92.45  ? 129 PRO A CD  1 
ATOM 1039 N N   . PRO A 1 130 ? -78.312 14.534  142.403 1.00 95.15  ? 130 PRO A N   1 
ATOM 1040 C CA  . PRO A 1 130 ? -79.048 13.265  142.565 1.00 95.15  ? 130 PRO A CA  1 
ATOM 1041 C C   . PRO A 1 130 ? -80.352 13.173  141.789 1.00 95.15  ? 130 PRO A C   1 
ATOM 1042 O O   . PRO A 1 130 ? -80.701 12.087  141.308 1.00 95.15  ? 130 PRO A O   1 
ATOM 1043 C CB  . PRO A 1 130 ? -79.308 13.218  144.078 1.00 95.15  ? 130 PRO A CB  1 
ATOM 1044 C CG  . PRO A 1 130 ? -78.178 13.952  144.668 1.00 95.15  ? 130 PRO A CG  1 
ATOM 1045 C CD  . PRO A 1 130 ? -77.925 15.093  143.710 1.00 95.15  ? 130 PRO A CD  1 
ATOM 1046 N N   . ALA A 1 131 ? -81.086 14.278  141.651 1.00 92.15  ? 131 ALA A N   1 
ATOM 1047 C CA  . ALA A 1 131 ? -82.387 14.242  140.989 1.00 92.15  ? 131 ALA A CA  1 
ATOM 1048 C C   . ALA A 1 131 ? -82.291 13.951  139.497 1.00 92.15  ? 131 ALA A C   1 
ATOM 1049 O O   . ALA A 1 131 ? -83.308 13.616  138.883 1.00 92.15  ? 131 ALA A O   1 
ATOM 1050 C CB  . ALA A 1 131 ? -83.118 15.568  141.204 1.00 92.15  ? 131 ALA A CB  1 
ATOM 1051 N N   . TYR A 1 132 ? -81.108 14.072  138.902 1.00 92.85  ? 132 TYR A N   1 
ATOM 1052 C CA  . TYR A 1 132 ? -80.929 13.845  137.476 1.00 92.85  ? 132 TYR A CA  1 
ATOM 1053 C C   . TYR A 1 132 ? -79.863 12.798  137.181 1.00 92.85  ? 132 TYR A C   1 
ATOM 1054 O O   . TYR A 1 132 ? -79.597 12.521  136.007 1.00 92.85  ? 132 TYR A O   1 
ATOM 1055 C CB  . TYR A 1 132 ? -80.583 15.159  136.763 1.00 92.85  ? 132 TYR A CB  1 
ATOM 1056 C CG  . TYR A 1 132 ? -81.658 16.215  136.883 1.00 92.85  ? 132 TYR A CG  1 
ATOM 1057 C CD1 . TYR A 1 132 ? -82.836 16.117  136.153 1.00 92.85  ? 132 TYR A CD1 1 
ATOM 1058 C CD2 . TYR A 1 132 ? -81.500 17.307  137.723 1.00 92.85  ? 132 TYR A CD2 1 
ATOM 1059 C CE1 . TYR A 1 132 ? -83.831 17.065  136.271 1.00 92.85  ? 132 TYR A CE1 1 
ATOM 1060 C CE2 . TYR A 1 132 ? -82.485 18.272  137.833 1.00 92.85  ? 132 TYR A CE2 1 
ATOM 1061 C CZ  . TYR A 1 132 ? -83.650 18.141  137.110 1.00 92.85  ? 132 TYR A CZ  1 
ATOM 1062 O OH  . TYR A 1 132 ? -84.633 19.097  137.213 1.00 92.85  ? 132 TYR A OH  1 
ATOM 1063 N N   . ARG A 1 133 ? -79.249 12.219  138.204 1.00 91.41  ? 133 ARG A N   1 
ATOM 1064 C CA  . ARG A 1 133 ? -78.219 11.205  138.010 1.00 91.41  ? 133 ARG A CA  1 
ATOM 1065 C C   . ARG A 1 133 ? -78.854 9.884   137.587 1.00 91.41  ? 133 ARG A C   1 
ATOM 1066 O O   . ARG A 1 133 ? -79.707 9.362   138.317 1.00 91.41  ? 133 ARG A O   1 
ATOM 1067 C CB  . ARG A 1 133 ? -77.443 11.018  139.307 1.00 91.41  ? 133 ARG A CB  1 
ATOM 1068 C CG  . ARG A 1 133 ? -76.106 10.324  139.156 1.00 91.41  ? 133 ARG A CG  1 
ATOM 1069 C CD  . ARG A 1 133 ? -75.428 10.161  140.504 1.00 91.41  ? 133 ARG A CD  1 
ATOM 1070 N NE  . ARG A 1 133 ? -75.238 11.435  141.186 1.00 91.41  ? 133 ARG A NE  1 
ATOM 1071 C CZ  . ARG A 1 133 ? -75.108 11.572  142.498 1.00 91.41  ? 133 ARG A CZ  1 
ATOM 1072 N NH1 . ARG A 1 133 ? -75.100 10.526  143.307 1.00 91.41  ? 133 ARG A NH1 1 
ATOM 1073 N NH2 . ARG A 1 133 ? -74.981 12.791  143.013 1.00 91.41  ? 133 ARG A NH2 1 
ATOM 1074 N N   . PRO A 1 134 ? -78.490 9.311   136.442 1.00 90.10  ? 134 PRO A N   1 
ATOM 1075 C CA  . PRO A 1 134 ? -79.054 8.014   136.051 1.00 90.10  ? 134 PRO A CA  1 
ATOM 1076 C C   . PRO A 1 134 ? -78.582 6.903   136.974 1.00 90.10  ? 134 PRO A C   1 
ATOM 1077 O O   . PRO A 1 134 ? -77.427 6.916   137.428 1.00 90.10  ? 134 PRO A O   1 
ATOM 1078 C CB  . PRO A 1 134 ? -78.531 7.816   134.621 1.00 90.10  ? 134 PRO A CB  1 
ATOM 1079 C CG  . PRO A 1 134 ? -77.267 8.582   134.586 1.00 90.10  ? 134 PRO A CG  1 
ATOM 1080 C CD  . PRO A 1 134 ? -77.513 9.791   135.451 1.00 90.10  ? 134 PRO A CD  1 
ATOM 1081 N N   . PRO A 1 135 ? -79.436 5.920   137.279 1.00 93.62  ? 135 PRO A N   1 
ATOM 1082 C CA  . PRO A 1 135 ? -79.035 4.873   138.235 1.00 93.62  ? 135 PRO A CA  1 
ATOM 1083 C C   . PRO A 1 135 ? -77.907 3.972   137.752 1.00 93.62  ? 135 PRO A C   1 
ATOM 1084 O O   . PRO A 1 135 ? -77.271 3.317   138.587 1.00 93.62  ? 135 PRO A O   1 
ATOM 1085 C CB  . PRO A 1 135 ? -80.326 4.066   138.433 1.00 93.62  ? 135 PRO A CB  1 
ATOM 1086 C CG  . PRO A 1 135 ? -81.412 5.021   138.119 1.00 93.62  ? 135 PRO A CG  1 
ATOM 1087 C CD  . PRO A 1 135 ? -80.875 5.832   136.975 1.00 93.62  ? 135 PRO A CD  1 
ATOM 1088 N N   . ASN A 1 136 ? -77.638 3.908   136.448 1.00 97.41  ? 136 ASN A N   1 
ATOM 1089 C CA  . ASN A 1 136 ? -76.578 3.052   135.909 1.00 97.41  ? 136 ASN A CA  1 
ATOM 1090 C C   . ASN A 1 136 ? -75.245 3.793   135.917 1.00 97.41  ? 136 ASN A C   1 
ATOM 1091 O O   . ASN A 1 136 ? -74.916 4.538   134.993 1.00 97.41  ? 136 ASN A O   1 
ATOM 1092 C CB  . ASN A 1 136 ? -76.941 2.584   134.506 1.00 97.41  ? 136 ASN A CB  1 
ATOM 1093 C CG  . ASN A 1 136 ? -78.088 1.597   134.504 1.00 97.41  ? 136 ASN A CG  1 
ATOM 1094 O OD1 . ASN A 1 136 ? -78.155 0.703   135.347 1.00 97.41  ? 136 ASN A OD1 1 
ATOM 1095 N ND2 . ASN A 1 136 ? -79.004 1.757   133.556 1.00 97.41  ? 136 ASN A ND2 1 
ATOM 1096 N N   . ALA A 1 137 ? -74.467 3.582   136.975 1.00 89.18  ? 137 ALA A N   1 
ATOM 1097 C CA  . ALA A 1 137 ? -73.113 4.107   137.024 1.00 89.18  ? 137 ALA A CA  1 
ATOM 1098 C C   . ALA A 1 137 ? -72.247 3.470   135.934 1.00 89.18  ? 137 ALA A C   1 
ATOM 1099 O O   . ALA A 1 137 ? -72.428 2.298   135.594 1.00 89.18  ? 137 ALA A O   1 
ATOM 1100 C CB  . ALA A 1 137 ? -72.493 3.852   138.395 1.00 89.18  ? 137 ALA A CB  1 
ATOM 1101 N N   . PRO A 1 138 ? -71.299 4.220   135.367 1.00 87.39  ? 138 PRO A N   1 
ATOM 1102 C CA  . PRO A 1 138 ? -70.419 3.646   134.340 1.00 87.39  ? 138 PRO A CA  1 
ATOM 1103 C C   . PRO A 1 138 ? -69.620 2.466   134.874 1.00 87.39  ? 138 PRO A C   1 
ATOM 1104 O O   . PRO A 1 138 ? -69.227 2.432   136.042 1.00 87.39  ? 138 PRO A O   1 
ATOM 1105 C CB  . PRO A 1 138 ? -69.499 4.813   133.963 1.00 87.39  ? 138 PRO A CB  1 
ATOM 1106 C CG  . PRO A 1 138 ? -70.242 6.034   134.361 1.00 87.39  ? 138 PRO A CG  1 
ATOM 1107 C CD  . PRO A 1 138 ? -71.022 5.649   135.580 1.00 87.39  ? 138 PRO A CD  1 
ATOM 1108 N N   . ILE A 1 139 ? -69.385 1.484   134.005 1.00 90.47  ? 139 ILE A N   1 
ATOM 1109 C CA  . ILE A 1 139 ? -68.609 0.304   134.379 1.00 90.47  ? 139 ILE A CA  1 
ATOM 1110 C C   . ILE A 1 139 ? -67.799 -0.169  133.180 1.00 90.47  ? 139 ILE A C   1 
ATOM 1111 O O   . ILE A 1 139 ? -68.257 -0.105  132.036 1.00 90.47  ? 139 ILE A O   1 
ATOM 1112 C CB  . ILE A 1 139 ? -69.521 -0.824  134.903 1.00 90.47  ? 139 ILE A CB  1 
ATOM 1113 C CG1 . ILE A 1 139 ? -68.680 -1.933  135.528 1.00 90.47  ? 139 ILE A CG1 1 
ATOM 1114 C CG2 . ILE A 1 139 ? -70.381 -1.383  133.777 1.00 90.47  ? 139 ILE A CG2 1 
ATOM 1115 C CD1 . ILE A 1 139 ? -69.485 -2.918  136.339 1.00 90.47  ? 139 ILE A CD1 1 
ATOM 1116 N N   . LEU A 1 140 ? -66.587 -0.644  133.457 1.00 92.25  ? 140 LEU A N   1 
ATOM 1117 C CA  . LEU A 1 140 ? -65.693 -1.141  132.418 1.00 92.25  ? 140 LEU A CA  1 
ATOM 1118 C C   . LEU A 1 140 ? -66.148 -2.513  131.934 1.00 92.25  ? 140 LEU A C   1 
ATOM 1119 O O   . LEU A 1 140 ? -66.479 -3.386  132.741 1.00 92.25  ? 140 LEU A O   1 
ATOM 1120 C CB  . LEU A 1 140 ? -64.261 -1.220  132.944 1.00 92.25  ? 140 LEU A CB  1 
ATOM 1121 C CG  . LEU A 1 140 ? -63.580 0.114   133.249 1.00 92.25  ? 140 LEU A CG  1 
ATOM 1122 C CD1 . LEU A 1 140 ? -62.347 -0.108  134.108 1.00 92.25  ? 140 LEU A CD1 1 
ATOM 1123 C CD2 . LEU A 1 140 ? -63.217 0.842   131.964 1.00 92.25  ? 140 LEU A CD2 1 
ATOM 1124 N N   . SER A 1 141 ? -66.165 -2.708  130.617 1.00 107.90 ? 141 SER A N   1 
ATOM 1125 C CA  . SER A 1 141 ? -66.496 -4.012  130.060 1.00 107.90 ? 141 SER A CA  1 
ATOM 1126 C C   . SER A 1 141 ? -65.868 -4.161  128.682 1.00 107.90 ? 141 SER A C   1 
ATOM 1127 O O   . SER A 1 141 ? -65.685 -3.183  127.954 1.00 107.90 ? 141 SER A O   1 
ATOM 1128 C CB  . SER A 1 141 ? -68.013 -4.210  129.961 1.00 107.90 ? 141 SER A CB  1 
ATOM 1129 O OG  . SER A 1 141 ? -68.325 -5.466  129.388 1.00 107.90 ? 141 SER A OG  1 
ATOM 1130 N N   . THR A 1 142 ? -65.534 -5.405  128.337 1.00 116.87 ? 142 THR A N   1 
ATOM 1131 C CA  . THR A 1 142 ? -64.936 -5.734  127.050 1.00 116.87 ? 142 THR A CA  1 
ATOM 1132 C C   . THR A 1 142 ? -65.957 -6.159  126.006 1.00 116.87 ? 142 THR A C   1 
ATOM 1133 O O   . THR A 1 142 ? -65.617 -6.220  124.820 1.00 116.87 ? 142 THR A O   1 
ATOM 1134 C CB  . THR A 1 142 ? -63.904 -6.855  127.211 1.00 116.87 ? 142 THR A CB  1 
ATOM 1135 O OG1 . THR A 1 142 ? -64.513 -7.979  127.858 1.00 116.87 ? 142 THR A OG1 1 
ATOM 1136 C CG2 . THR A 1 142 ? -62.719 -6.384  128.033 1.00 116.87 ? 142 THR A CG2 1 
ATOM 1137 N N   . LEU A 1 143 ? -67.186 -6.455  126.409 1.00 129.51 ? 143 LEU A N   1 
ATOM 1138 C CA  . LEU A 1 143 ? -68.195 -6.885  125.452 1.00 129.51 ? 143 LEU A CA  1 
ATOM 1139 C C   . LEU A 1 143 ? -68.493 -5.757  124.469 1.00 129.51 ? 143 LEU A C   1 
ATOM 1140 O O   . LEU A 1 143 ? -68.659 -4.603  124.890 1.00 129.51 ? 143 LEU A O   1 
ATOM 1141 C CB  . LEU A 1 143 ? -69.473 -7.301  126.179 1.00 129.51 ? 143 LEU A CB  1 
ATOM 1142 C CG  . LEU A 1 143 ? -69.365 -8.533  127.080 1.00 129.51 ? 143 LEU A CG  1 
ATOM 1143 C CD1 . LEU A 1 143 ? -70.669 -8.755  127.824 1.00 129.51 ? 143 LEU A CD1 1 
ATOM 1144 C CD2 . LEU A 1 143 ? -68.990 -9.770  126.281 1.00 129.51 ? 143 LEU A CD2 1 
ATOM 1145 N N   . PRO A 1 144 ? -68.572 -6.037  123.157 1.00 142.02 ? 144 PRO A N   1 
ATOM 1146 C CA  . PRO A 1 144 ? -68.829 -4.979  122.177 1.00 142.02 ? 144 PRO A CA  1 
ATOM 1147 C C   . PRO A 1 144 ? -70.243 -4.415  122.280 1.00 142.02 ? 144 PRO A C   1 
ATOM 1148 O O   . PRO A 1 144 ? -71.182 -5.191  122.455 1.00 142.02 ? 144 PRO A O   1 
ATOM 1149 C CB  . PRO A 1 144 ? -68.620 -5.686  120.833 1.00 142.02 ? 144 PRO A CB  1 
ATOM 1150 C CG  . PRO A 1 144 ? -68.936 -7.106  121.107 1.00 142.02 ? 144 PRO A CG  1 
ATOM 1151 C CD  . PRO A 1 144 ? -68.472 -7.360  122.516 1.00 142.02 ? 144 PRO A CD  1 
ATOM 1152 N N   . MET B 1 1   ? -48.576 -15.141 145.842 1.00 111.34 ? 1   MET B N   1 
ATOM 1153 C CA  . MET B 1 1   ? -47.395 -14.804 145.002 1.00 111.34 ? 1   MET B CA  1 
ATOM 1154 C C   . MET B 1 1   ? -46.123 -15.141 145.767 1.00 111.34 ? 1   MET B C   1 
ATOM 1155 O O   . MET B 1 1   ? -46.079 -14.984 146.987 1.00 111.34 ? 1   MET B O   1 
ATOM 1156 C CB  . MET B 1 1   ? -47.405 -13.319 144.636 1.00 111.34 ? 1   MET B CB  1 
ATOM 1157 C CG  . MET B 1 1   ? -48.544 -12.891 143.723 1.00 111.34 ? 1   MET B CG  1 
ATOM 1158 S SD  . MET B 1 1   ? -48.526 -13.708 142.124 1.00 111.34 ? 1   MET B SD  1 
ATOM 1159 C CE  . MET B 1 1   ? -49.729 -14.998 142.404 1.00 111.34 ? 1   MET B CE  1 
ATOM 1160 N N   . ASP B 1 2   ? -45.083 -15.603 145.072 1.00 114.72 ? 2   ASP B N   1 
ATOM 1161 C CA  . ASP B 1 2   ? -43.716 -15.399 145.531 1.00 114.72 ? 2   ASP B CA  1 
ATOM 1162 C C   . ASP B 1 2   ? -42.847 -14.819 144.426 1.00 114.72 ? 2   ASP B C   1 
ATOM 1163 O O   . ASP B 1 2   ? -42.858 -15.306 143.291 1.00 114.72 ? 2   ASP B O   1 
ATOM 1164 C CB  . ASP B 1 2   ? -43.118 -16.716 146.050 1.00 114.72 ? 2   ASP B CB  1 
ATOM 1165 C CG  . ASP B 1 2   ? -43.025 -17.788 144.976 1.00 114.72 ? 2   ASP B CG  1 
ATOM 1166 O OD1 . ASP B 1 2   ? -43.460 -17.545 143.833 1.00 114.72 ? 2   ASP B OD1 1 
ATOM 1167 O OD2 . ASP B 1 2   ? -42.506 -18.882 145.279 1.00 114.72 ? 2   ASP B OD2 1 
ATOM 1168 N N   . ILE B 1 3   ? -42.113 -13.762 144.762 1.00 103.03 ? 3   ILE B N   1 
ATOM 1169 C CA  . ILE B 1 3   ? -41.442 -12.908 143.791 1.00 103.03 ? 3   ILE B CA  1 
ATOM 1170 C C   . ILE B 1 3   ? -39.995 -12.749 144.235 1.00 103.03 ? 3   ILE B C   1 
ATOM 1171 O O   . ILE B 1 3   ? -39.713 -12.694 145.436 1.00 103.03 ? 3   ILE B O   1 
ATOM 1172 C CB  . ILE B 1 3   ? -42.143 -11.542 143.642 1.00 103.03 ? 3   ILE B CB  1 
ATOM 1173 C CG1 . ILE B 1 3   ? -43.543 -11.736 143.056 1.00 103.03 ? 3   ILE B CG1 1 
ATOM 1174 C CG2 . ILE B 1 3   ? -41.323 -10.604 142.756 1.00 103.03 ? 3   ILE B CG2 1 
ATOM 1175 C CD1 . ILE B 1 3   ? -44.408 -10.509 143.118 1.00 103.03 ? 3   ILE B CD1 1 
ATOM 1176 N N   . ASP B 1 4   ? -39.077 -12.675 143.272 1.00 101.23 ? 4   ASP B N   1 
ATOM 1177 C CA  . ASP B 1 4   ? -37.719 -12.229 143.552 1.00 101.23 ? 4   ASP B CA  1 
ATOM 1178 C C   . ASP B 1 4   ? -37.512 -10.855 142.932 1.00 101.23 ? 4   ASP B C   1 
ATOM 1179 O O   . ASP B 1 4   ? -37.641 -10.723 141.706 1.00 101.23 ? 4   ASP B O   1 
ATOM 1180 C CB  . ASP B 1 4   ? -36.706 -13.231 143.001 1.00 101.23 ? 4   ASP B CB  1 
ATOM 1181 C CG  . ASP B 1 4   ? -35.265 -12.829 143.269 1.00 101.23 ? 4   ASP B CG  1 
ATOM 1182 O OD1 . ASP B 1 4   ? -34.967 -11.618 143.329 1.00 101.23 ? 4   ASP B OD1 1 
ATOM 1183 O OD2 . ASP B 1 4   ? -34.422 -13.736 143.424 1.00 101.23 ? 4   ASP B OD2 1 
ATOM 1184 N N   . PRO B 1 5   ? -37.192 -9.809  143.704 1.00 95.45  ? 5   PRO B N   1 
ATOM 1185 C CA  . PRO B 1 5   ? -37.065 -8.476  143.094 1.00 95.45  ? 5   PRO B CA  1 
ATOM 1186 C C   . PRO B 1 5   ? -35.916 -8.359  142.108 1.00 95.45  ? 5   PRO B C   1 
ATOM 1187 O O   . PRO B 1 5   ? -35.944 -7.463  141.256 1.00 95.45  ? 5   PRO B O   1 
ATOM 1188 C CB  . PRO B 1 5   ? -36.852 -7.551  144.304 1.00 95.45  ? 5   PRO B CB  1 
ATOM 1189 C CG  . PRO B 1 5   ? -36.322 -8.435  145.373 1.00 95.45  ? 5   PRO B CG  1 
ATOM 1190 C CD  . PRO B 1 5   ? -36.964 -9.772  145.156 1.00 95.45  ? 5   PRO B CD  1 
ATOM 1191 N N   . TYR B 1 6   ? -34.911 -9.229  142.196 1.00 92.91  ? 6   TYR B N   1 
ATOM 1192 C CA  . TYR B 1 6   ? -33.724 -9.136  141.355 1.00 92.91  ? 6   TYR B CA  1 
ATOM 1193 C C   . TYR B 1 6   ? -33.837 -9.969  140.088 1.00 92.91  ? 6   TYR B C   1 
ATOM 1194 O O   . TYR B 1 6   ? -33.049 -9.772  139.157 1.00 92.91  ? 6   TYR B O   1 
ATOM 1195 C CB  . TYR B 1 6   ? -32.489 -9.563  142.151 1.00 92.91  ? 6   TYR B CB  1 
ATOM 1196 C CG  . TYR B 1 6   ? -32.314 -8.786  143.434 1.00 92.91  ? 6   TYR B CG  1 
ATOM 1197 C CD1 . TYR B 1 6   ? -31.987 -7.439  143.413 1.00 92.91  ? 6   TYR B CD1 1 
ATOM 1198 C CD2 . TYR B 1 6   ? -32.484 -9.398  144.667 1.00 92.91  ? 6   TYR B CD2 1 
ATOM 1199 C CE1 . TYR B 1 6   ? -31.829 -6.724  144.582 1.00 92.91  ? 6   TYR B CE1 1 
ATOM 1200 C CE2 . TYR B 1 6   ? -32.330 -8.691  145.842 1.00 92.91  ? 6   TYR B CE2 1 
ATOM 1201 C CZ  . TYR B 1 6   ? -32.006 -7.354  145.794 1.00 92.91  ? 6   TYR B CZ  1 
ATOM 1202 O OH  . TYR B 1 6   ? -31.854 -6.646  146.963 1.00 92.91  ? 6   TYR B OH  1 
ATOM 1203 N N   . LYS B 1 7   ? -34.802 -10.885 140.037 1.00 97.09  ? 7   LYS B N   1 
ATOM 1204 C CA  . LYS B 1 7   ? -34.851 -11.881 138.974 1.00 97.09  ? 7   LYS B CA  1 
ATOM 1205 C C   . LYS B 1 7   ? -35.093 -11.225 137.623 1.00 97.09  ? 7   LYS B C   1 
ATOM 1206 O O   . LYS B 1 7   ? -34.557 -11.665 136.601 1.00 97.09  ? 7   LYS B O   1 
ATOM 1207 C CB  . LYS B 1 7   ? -35.949 -12.894 139.285 1.00 97.09  ? 7   LYS B CB  1 
ATOM 1208 C CG  . LYS B 1 7   ? -36.021 -14.089 138.365 1.00 97.09  ? 7   LYS B CG  1 
ATOM 1209 C CD  . LYS B 1 7   ? -36.885 -15.163 139.013 1.00 97.09  ? 7   LYS B CD  1 
ATOM 1210 C CE  . LYS B 1 7   ? -36.940 -16.444 138.198 1.00 97.09  ? 7   LYS B CE  1 
ATOM 1211 N NZ  . LYS B 1 7   ? -37.202 -16.210 136.757 1.00 97.09  ? 7   LYS B NZ  1 
ATOM 1212 N N   . GLU B 1 8   ? -35.904 -10.170 137.608 1.00 99.86  ? 8   GLU B N   1 
ATOM 1213 C CA  . GLU B 1 8   ? -36.115 -9.378  136.406 1.00 99.86  ? 8   GLU B CA  1 
ATOM 1214 C C   . GLU B 1 8   ? -34.834 -8.735  135.886 1.00 99.86  ? 8   GLU B C   1 
ATOM 1215 O O   . GLU B 1 8   ? -34.762 -8.397  134.700 1.00 99.86  ? 8   GLU B O   1 
ATOM 1216 C CB  . GLU B 1 8   ? -37.152 -8.305  136.736 1.00 99.86  ? 8   GLU B CB  1 
ATOM 1217 C CG  . GLU B 1 8   ? -37.427 -7.271  135.676 1.00 99.86  ? 8   GLU B CG  1 
ATOM 1218 C CD  . GLU B 1 8   ? -38.553 -6.350  136.099 1.00 99.86  ? 8   GLU B CD  1 
ATOM 1219 O OE1 . GLU B 1 8   ? -38.951 -6.419  137.279 1.00 99.86  ? 8   GLU B OE1 1 
ATOM 1220 O OE2 . GLU B 1 8   ? -39.039 -5.555  135.272 1.00 99.86  ? 8   GLU B OE2 1 
ATOM 1221 N N   . PHE B 1 9   ? -33.829 -8.551  136.739 1.00 93.10  ? 9   PHE B N   1 
ATOM 1222 C CA  . PHE B 1 9   ? -32.550 -7.978  136.341 1.00 93.10  ? 9   PHE B CA  1 
ATOM 1223 C C   . PHE B 1 9   ? -31.450 -9.016  136.162 1.00 93.10  ? 9   PHE B C   1 
ATOM 1224 O O   . PHE B 1 9   ? -30.310 -8.643  135.871 1.00 93.10  ? 9   PHE B O   1 
ATOM 1225 C CB  . PHE B 1 9   ? -32.119 -6.910  137.347 1.00 93.10  ? 9   PHE B CB  1 
ATOM 1226 C CG  . PHE B 1 9   ? -33.116 -5.800  137.501 1.00 93.10  ? 9   PHE B CG  1 
ATOM 1227 C CD1 . PHE B 1 9   ? -33.180 -4.784  136.564 1.00 93.10  ? 9   PHE B CD1 1 
ATOM 1228 C CD2 . PHE B 1 9   ? -34.011 -5.789  138.553 1.00 93.10  ? 9   PHE B CD2 1 
ATOM 1229 C CE1 . PHE B 1 9   ? -34.102 -3.767  136.684 1.00 93.10  ? 9   PHE B CE1 1 
ATOM 1230 C CE2 . PHE B 1 9   ? -34.934 -4.769  138.682 1.00 93.10  ? 9   PHE B CE2 1 
ATOM 1231 C CZ  . PHE B 1 9   ? -34.979 -3.759  137.746 1.00 93.10  ? 9   PHE B CZ  1 
ATOM 1232 N N   . GLY B 1 10  ? -31.754 -10.300 136.334 1.00 93.64  ? 10  GLY B N   1 
ATOM 1233 C CA  . GLY B 1 10  ? -30.764 -11.336 136.114 1.00 93.64  ? 10  GLY B CA  1 
ATOM 1234 C C   . GLY B 1 10  ? -29.819 -11.578 137.267 1.00 93.64  ? 10  GLY B C   1 
ATOM 1235 O O   . GLY B 1 10  ? -28.745 -12.150 137.063 1.00 93.64  ? 10  GLY B O   1 
ATOM 1236 N N   . ALA B 1 11  ? -30.187 -11.164 138.472 1.00 92.19  ? 11  ALA B N   1 
ATOM 1237 C CA  . ALA B 1 11  ? -29.489 -11.510 139.702 1.00 92.19  ? 11  ALA B CA  1 
ATOM 1238 C C   . ALA B 1 11  ? -30.471 -12.201 140.642 1.00 92.19  ? 11  ALA B C   1 
ATOM 1239 O O   . ALA B 1 11  ? -31.648 -12.374 140.321 1.00 92.19  ? 11  ALA B O   1 
ATOM 1240 C CB  . ALA B 1 11  ? -28.881 -10.266 140.353 1.00 92.19  ? 11  ALA B CB  1 
ATOM 1241 N N   . THR B 1 12  ? -29.984 -12.607 141.811 1.00 92.94  ? 12  THR B N   1 
ATOM 1242 C CA  . THR B 1 12  ? -30.823 -13.310 142.770 1.00 92.94  ? 12  THR B CA  1 
ATOM 1243 C C   . THR B 1 12  ? -30.490 -12.864 144.186 1.00 92.94  ? 12  THR B C   1 
ATOM 1244 O O   . THR B 1 12  ? -29.403 -12.353 144.467 1.00 92.94  ? 12  THR B O   1 
ATOM 1245 C CB  . THR B 1 12  ? -30.653 -14.829 142.660 1.00 92.94  ? 12  THR B CB  1 
ATOM 1246 O OG1 . THR B 1 12  ? -29.304 -15.184 142.986 1.00 92.94  ? 12  THR B OG1 1 
ATOM 1247 C CG2 . THR B 1 12  ? -30.976 -15.305 141.253 1.00 92.94  ? 12  THR B CG2 1 
ATOM 1248 N N   . VAL B 1 13  ? -31.460 -13.074 145.076 1.00 93.09  ? 13  VAL B N   1 
ATOM 1249 C CA  . VAL B 1 13  ? -31.262 -12.840 146.505 1.00 93.09  ? 13  VAL B CA  1 
ATOM 1250 C C   . VAL B 1 13  ? -30.049 -13.599 147.028 1.00 93.09  ? 13  VAL B C   1 
ATOM 1251 O O   . VAL B 1 13  ? -29.267 -13.078 147.832 1.00 93.09  ? 13  VAL B O   1 
ATOM 1252 C CB  . VAL B 1 13  ? -32.542 -13.221 147.275 1.00 93.09  ? 13  VAL B CB  1 
ATOM 1253 C CG1 . VAL B 1 13  ? -32.289 -13.259 148.778 1.00 93.09  ? 13  VAL B CG1 1 
ATOM 1254 C CG2 . VAL B 1 13  ? -33.673 -12.257 146.940 1.00 93.09  ? 13  VAL B CG2 1 
ATOM 1255 N N   . GLU B 1 14  ? -29.880 -14.846 146.587 1.00 95.07  ? 14  GLU B N   1 
ATOM 1256 C CA  . GLU B 1 14  ? -28.735 -15.644 147.017 1.00 95.07  ? 14  GLU B CA  1 
ATOM 1257 C C   . GLU B 1 14  ? -27.416 -14.943 146.716 1.00 95.07  ? 14  GLU B C   1 
ATOM 1258 O O   . GLU B 1 14  ? -26.551 -14.822 147.591 1.00 95.07  ? 14  GLU B O   1 
ATOM 1259 C CB  . GLU B 1 14  ? -28.779 -17.016 146.346 1.00 95.07  ? 14  GLU B CB  1 
ATOM 1260 C CG  . GLU B 1 14  ? -29.890 -17.929 146.855 1.00 95.07  ? 14  GLU B CG  1 
ATOM 1261 C CD  . GLU B 1 14  ? -31.250 -17.567 146.297 1.00 95.07  ? 14  GLU B CD  1 
ATOM 1262 O OE1 . GLU B 1 14  ? -31.312 -16.727 145.376 1.00 95.07  ? 14  GLU B OE1 1 
ATOM 1263 O OE2 . GLU B 1 14  ? -32.260 -18.117 146.782 1.00 95.07  ? 14  GLU B OE2 1 
ATOM 1264 N N   . LEU B 1 15  ? -27.243 -14.476 145.480 1.00 88.99  ? 15  LEU B N   1 
ATOM 1265 C CA  . LEU B 1 15  ? -25.980 -13.857 145.092 1.00 88.99  ? 15  LEU B CA  1 
ATOM 1266 C C   . LEU B 1 15  ? -25.661 -12.623 145.932 1.00 88.99  ? 15  LEU B C   1 
ATOM 1267 O O   . LEU B 1 15  ? -24.501 -12.405 146.302 1.00 88.99  ? 15  LEU B O   1 
ATOM 1268 C CB  . LEU B 1 15  ? -26.023 -13.495 143.606 1.00 88.99  ? 15  LEU B CB  1 
ATOM 1269 C CG  . LEU B 1 15  ? -24.805 -12.766 143.033 1.00 88.99  ? 15  LEU B CG  1 
ATOM 1270 C CD1 . LEU B 1 15  ? -23.551 -13.618 143.150 1.00 88.99  ? 15  LEU B CD1 1 
ATOM 1271 C CD2 . LEU B 1 15  ? -25.045 -12.380 141.583 1.00 88.99  ? 15  LEU B CD2 1 
ATOM 1272 N N   . LEU B 1 16  ? -26.666 -11.806 146.249 1.00 89.30  ? 16  LEU B N   1 
ATOM 1273 C CA  . LEU B 1 16  ? -26.432 -10.633 147.087 1.00 89.30  ? 16  LEU B CA  1 
ATOM 1274 C C   . LEU B 1 16  ? -26.295 -10.948 148.572 1.00 89.30  ? 16  LEU B C   1 
ATOM 1275 O O   . LEU B 1 16  ? -25.711 -10.143 149.304 1.00 89.30  ? 16  LEU B O   1 
ATOM 1276 C CB  . LEU B 1 16  ? -27.565 -9.625  146.897 1.00 89.30  ? 16  LEU B CB  1 
ATOM 1277 C CG  . LEU B 1 16  ? -27.404 -8.674  145.711 1.00 89.30  ? 16  LEU B CG  1 
ATOM 1278 C CD1 . LEU B 1 16  ? -27.469 -9.433  144.400 1.00 89.30  ? 16  LEU B CD1 1 
ATOM 1279 C CD2 . LEU B 1 16  ? -28.467 -7.591  145.757 1.00 89.30  ? 16  LEU B CD2 1 
ATOM 1280 N N   . SER B 1 17  ? -26.810 -12.085 149.039 1.00 89.70  ? 17  SER B N   1 
ATOM 1281 C CA  . SER B 1 17  ? -26.820 -12.370 150.471 1.00 89.70  ? 17  SER B CA  1 
ATOM 1282 C C   . SER B 1 17  ? -25.433 -12.550 151.078 1.00 89.70  ? 17  SER B C   1 
ATOM 1283 O O   . SER B 1 17  ? -25.325 -12.606 152.308 1.00 89.70  ? 17  SER B O   1 
ATOM 1284 C CB  . SER B 1 17  ? -27.651 -13.625 150.741 1.00 89.70  ? 17  SER B CB  1 
ATOM 1285 O OG  . SER B 1 17  ? -26.992 -14.784 150.266 1.00 89.70  ? 17  SER B OG  1 
ATOM 1286 N N   . PHE B 1 18  ? -24.375 -12.642 150.270 1.00 88.93  ? 18  PHE B N   1 
ATOM 1287 C CA  . PHE B 1 18  ? -23.016 -12.669 150.804 1.00 88.93  ? 18  PHE B CA  1 
ATOM 1288 C C   . PHE B 1 18  ? -22.487 -11.318 151.280 1.00 88.93  ? 18  PHE B C   1 
ATOM 1289 O O   . PHE B 1 18  ? -21.528 -11.296 152.058 1.00 88.93  ? 18  PHE B O   1 
ATOM 1290 C CB  . PHE B 1 18  ? -22.061 -13.233 149.750 1.00 88.93  ? 18  PHE B CB  1 
ATOM 1291 C CG  . PHE B 1 18  ? -22.265 -14.693 149.474 1.00 88.93  ? 18  PHE B CG  1 
ATOM 1292 C CD1 . PHE B 1 18  ? -21.793 -15.650 150.354 1.00 88.93  ? 18  PHE B CD1 1 
ATOM 1293 C CD2 . PHE B 1 18  ? -22.902 -15.110 148.319 1.00 88.93  ? 18  PHE B CD2 1 
ATOM 1294 C CE1 . PHE B 1 18  ? -21.962 -16.994 150.094 1.00 88.93  ? 18  PHE B CE1 1 
ATOM 1295 C CE2 . PHE B 1 18  ? -23.082 -16.451 148.059 1.00 88.93  ? 18  PHE B CE2 1 
ATOM 1296 C CZ  . PHE B 1 18  ? -22.613 -17.394 148.947 1.00 88.93  ? 18  PHE B CZ  1 
ATOM 1297 N N   . LEU B 1 19  ? -23.062 -10.204 150.850 1.00 89.03  ? 19  LEU B N   1 
ATOM 1298 C CA  . LEU B 1 19  ? -22.568 -8.904  151.307 1.00 89.03  ? 19  LEU B CA  1 
ATOM 1299 C C   . LEU B 1 19  ? -22.872 -8.691  152.790 1.00 89.03  ? 19  LEU B C   1 
ATOM 1300 O O   . LEU B 1 19  ? -24.021 -8.866  153.212 1.00 89.03  ? 19  LEU B O   1 
ATOM 1301 C CB  . LEU B 1 19  ? -23.180 -7.783  150.475 1.00 89.03  ? 19  LEU B CB  1 
ATOM 1302 C CG  . LEU B 1 19  ? -22.921 -7.867  148.968 1.00 89.03  ? 19  LEU B CG  1 
ATOM 1303 C CD1 . LEU B 1 19  ? -23.727 -6.815  148.231 1.00 89.03  ? 19  LEU B CD1 1 
ATOM 1304 C CD2 . LEU B 1 19  ? -21.439 -7.719  148.653 1.00 89.03  ? 19  LEU B CD2 1 
ATOM 1305 N N   . PRO B 1 20  ? -21.884 -8.320  153.605 1.00 89.70  ? 20  PRO B N   1 
ATOM 1306 C CA  . PRO B 1 20  ? -22.135 -8.101  155.033 1.00 89.70  ? 20  PRO B CA  1 
ATOM 1307 C C   . PRO B 1 20  ? -22.798 -6.757  155.313 1.00 89.70  ? 20  PRO B C   1 
ATOM 1308 O O   . PRO B 1 20  ? -22.741 -5.818  154.518 1.00 89.70  ? 20  PRO B O   1 
ATOM 1309 C CB  . PRO B 1 20  ? -20.730 -8.160  155.640 1.00 89.70  ? 20  PRO B CB  1 
ATOM 1310 C CG  . PRO B 1 20  ? -19.872 -7.610  154.568 1.00 89.70  ? 20  PRO B CG  1 
ATOM 1311 C CD  . PRO B 1 20  ? -20.455 -8.156  153.286 1.00 89.70  ? 20  PRO B CD  1 
ATOM 1312 N N   . SER B 1 21  ? -23.436 -6.688  156.487 1.00 96.30  ? 21  SER B N   1 
ATOM 1313 C CA  . SER B 1 21  ? -24.189 -5.499  156.883 1.00 96.30  ? 21  SER B CA  1 
ATOM 1314 C C   . SER B 1 21  ? -23.331 -4.240  156.981 1.00 96.30  ? 21  SER B C   1 
ATOM 1315 O O   . SER B 1 21  ? -23.861 -3.133  156.837 1.00 96.30  ? 21  SER B O   1 
ATOM 1316 C CB  . SER B 1 21  ? -24.870 -5.750  158.229 1.00 96.30  ? 21  SER B CB  1 
ATOM 1317 O OG  . SER B 1 21  ? -25.719 -6.881  158.166 1.00 96.30  ? 21  SER B OG  1 
ATOM 1318 N N   . ASP B 1 22  ? -22.026 -4.374  157.219 1.00 96.90  ? 22  ASP B N   1 
ATOM 1319 C CA  . ASP B 1 22  ? -21.149 -3.209  157.281 1.00 96.90  ? 22  ASP B CA  1 
ATOM 1320 C C   . ASP B 1 22  ? -20.847 -2.621  155.910 1.00 96.90  ? 22  ASP B C   1 
ATOM 1321 O O   . ASP B 1 22  ? -20.297 -1.518  155.834 1.00 96.90  ? 22  ASP B O   1 
ATOM 1322 C CB  . ASP B 1 22  ? -19.836 -3.566  157.982 1.00 96.90  ? 22  ASP B CB  1 
ATOM 1323 C CG  . ASP B 1 22  ? -19.061 -4.650  157.262 1.00 96.90  ? 22  ASP B CG  1 
ATOM 1324 O OD1 . ASP B 1 22  ? -19.577 -5.180  156.257 1.00 96.90  ? 22  ASP B OD1 1 
ATOM 1325 O OD2 . ASP B 1 22  ? -17.943 -4.980  157.709 1.00 96.90  ? 22  ASP B OD2 1 
ATOM 1326 N N   . PHE B 1 23  ? -21.180 -3.336  154.837 1.00 88.98  ? 23  PHE B N   1 
ATOM 1327 C CA  . PHE B 1 23  ? -20.856 -2.878  153.491 1.00 88.98  ? 23  PHE B CA  1 
ATOM 1328 C C   . PHE B 1 23  ? -21.706 -1.682  153.066 1.00 88.98  ? 23  PHE B C   1 
ATOM 1329 O O   . PHE B 1 23  ? -21.208 -0.778  152.385 1.00 88.98  ? 23  PHE B O   1 
ATOM 1330 C CB  . PHE B 1 23  ? -21.033 -4.040  152.516 1.00 88.98  ? 23  PHE B CB  1 
ATOM 1331 C CG  . PHE B 1 23  ? -20.571 -3.747  151.119 1.00 88.98  ? 23  PHE B CG  1 
ATOM 1332 C CD1 . PHE B 1 23  ? -19.229 -3.819  150.791 1.00 88.98  ? 23  PHE B CD1 1 
ATOM 1333 C CD2 . PHE B 1 23  ? -21.474 -3.367  150.143 1.00 88.98  ? 23  PHE B CD2 1 
ATOM 1334 C CE1 . PHE B 1 23  ? -18.797 -3.509  149.519 1.00 88.98  ? 23  PHE B CE1 1 
ATOM 1335 C CE2 . PHE B 1 23  ? -21.048 -3.075  148.864 1.00 88.98  ? 23  PHE B CE2 1 
ATOM 1336 C CZ  . PHE B 1 23  ? -19.708 -3.143  148.552 1.00 88.98  ? 23  PHE B CZ  1 
ATOM 1337 N N   . PHE B 1 24  ? -22.987 -1.650  153.454 1.00 89.25  ? 24  PHE B N   1 
ATOM 1338 C CA  . PHE B 1 24  ? -23.882 -0.636  152.900 1.00 89.25  ? 24  PHE B CA  1 
ATOM 1339 C C   . PHE B 1 24  ? -23.783 0.689   153.662 1.00 89.25  ? 24  PHE B C   1 
ATOM 1340 O O   . PHE B 1 24  ? -23.780 0.699   154.896 1.00 89.25  ? 24  PHE B O   1 
ATOM 1341 C CB  . PHE B 1 24  ? -25.319 -1.145  152.941 1.00 89.25  ? 24  PHE B CB  1 
ATOM 1342 C CG  . PHE B 1 24  ? -25.512 -2.450  152.227 1.00 89.25  ? 24  PHE B CG  1 
ATOM 1343 C CD1 . PHE B 1 24  ? -25.410 -2.525  150.850 1.00 89.25  ? 24  PHE B CD1 1 
ATOM 1344 C CD2 . PHE B 1 24  ? -25.829 -3.596  152.932 1.00 89.25  ? 24  PHE B CD2 1 
ATOM 1345 C CE1 . PHE B 1 24  ? -25.593 -3.725  150.194 1.00 89.25  ? 24  PHE B CE1 1 
ATOM 1346 C CE2 . PHE B 1 24  ? -26.016 -4.799  152.280 1.00 89.25  ? 24  PHE B CE2 1 
ATOM 1347 C CZ  . PHE B 1 24  ? -25.888 -4.864  150.911 1.00 89.25  ? 24  PHE B CZ  1 
ATOM 1348 N N   . PRO B 1 25  ? -23.706 1.820   152.952 1.00 90.32  ? 25  PRO B N   1 
ATOM 1349 C CA  . PRO B 1 25  ? -23.853 3.134   153.596 1.00 90.32  ? 25  PRO B CA  1 
ATOM 1350 C C   . PRO B 1 25  ? -25.183 3.288   154.320 1.00 90.32  ? 25  PRO B C   1 
ATOM 1351 O O   . PRO B 1 25  ? -26.080 2.447   154.237 1.00 90.32  ? 25  PRO B O   1 
ATOM 1352 C CB  . PRO B 1 25  ? -23.733 4.120   152.427 1.00 90.32  ? 25  PRO B CB  1 
ATOM 1353 C CG  . PRO B 1 25  ? -23.000 3.368   151.379 1.00 90.32  ? 25  PRO B CG  1 
ATOM 1354 C CD  . PRO B 1 25  ? -23.493 1.963   151.504 1.00 90.32  ? 25  PRO B CD  1 
ATOM 1355 N N   . SER B 1 26  ? -25.304 4.399   155.048 1.00 95.29  ? 26  SER B N   1 
ATOM 1356 C CA  . SER B 1 26  ? -26.564 4.748   155.690 1.00 95.29  ? 26  SER B CA  1 
ATOM 1357 C C   . SER B 1 26  ? -27.618 5.152   154.657 1.00 95.29  ? 26  SER B C   1 
ATOM 1358 O O   . SER B 1 26  ? -27.309 5.545   153.529 1.00 95.29  ? 26  SER B O   1 
ATOM 1359 C CB  . SER B 1 26  ? -26.354 5.886   156.688 1.00 95.29  ? 26  SER B CB  1 
ATOM 1360 O OG  . SER B 1 26  ? -26.175 7.122   156.021 1.00 95.29  ? 26  SER B OG  1 
ATOM 1361 N N   . VAL B 1 27  ? -28.884 5.047   155.070 1.00 96.83  ? 27  VAL B N   1 
ATOM 1362 C CA  . VAL B 1 27  ? -30.006 5.504   154.248 1.00 96.83  ? 27  VAL B CA  1 
ATOM 1363 C C   . VAL B 1 27  ? -29.907 6.992   153.921 1.00 96.83  ? 27  VAL B C   1 
ATOM 1364 O O   . VAL B 1 27  ? -30.266 7.425   152.819 1.00 96.83  ? 27  VAL B O   1 
ATOM 1365 C CB  . VAL B 1 27  ? -31.335 5.177   154.956 1.00 96.83  ? 27  VAL B CB  1 
ATOM 1366 C CG1 . VAL B 1 27  ? -31.576 6.128   156.126 1.00 96.83  ? 27  VAL B CG1 1 
ATOM 1367 C CG2 . VAL B 1 27  ? -32.490 5.243   153.973 1.00 96.83  ? 27  VAL B CG2 1 
ATOM 1368 N N   . ARG B 1 28  ? -29.396 7.786   154.860 1.00 100.30 ? 28  ARG B N   1 
ATOM 1369 C CA  . ARG B 1 28  ? -29.234 9.243   154.640 1.00 100.30 ? 28  ARG B CA  1 
ATOM 1370 C C   . ARG B 1 28  ? -28.236 9.474   153.502 1.00 100.30 ? 28  ARG B C   1 
ATOM 1371 O O   . ARG B 1 28  ? -28.495 10.385  152.713 1.00 100.30 ? 28  ARG B O   1 
ATOM 1372 C CB  . ARG B 1 28  ? -28.798 9.930   155.931 1.00 100.30 ? 28  ARG B CB  1 
ATOM 1373 C CG  . ARG B 1 28  ? -29.880 9.974   156.998 1.00 100.30 ? 28  ARG B CG  1 
ATOM 1374 C CD  . ARG B 1 28  ? -29.492 10.894  158.136 1.00 100.30 ? 28  ARG B CD  1 
ATOM 1375 N NE  . ARG B 1 28  ? -30.579 11.068  159.088 1.00 100.30 ? 28  ARG B NE  1 
ATOM 1376 C CZ  . ARG B 1 28  ? -30.527 11.849  160.160 1.00 100.30 ? 28  ARG B CZ  1 
ATOM 1377 N NH1 . ARG B 1 28  ? -29.433 12.542  160.430 1.00 100.30 ? 28  ARG B NH1 1 
ATOM 1378 N NH2 . ARG B 1 28  ? -31.572 11.936  160.961 1.00 100.30 ? 28  ARG B NH2 1 
ATOM 1379 N N   . ASP B 1 29  ? -27.150 8.701   153.409 1.00 100.28 ? 29  ASP B N   1 
ATOM 1380 C CA  . ASP B 1 29  ? -26.197 8.829   152.312 1.00 100.28 ? 29  ASP B CA  1 
ATOM 1381 C C   . ASP B 1 29  ? -26.812 8.418   150.984 1.00 100.28 ? 29  ASP B C   1 
ATOM 1382 O O   . ASP B 1 29  ? -26.606 9.085   149.965 1.00 100.28 ? 29  ASP B O   1 
ATOM 1383 C CB  . ASP B 1 29  ? -24.953 7.992   152.602 1.00 100.28 ? 29  ASP B CB  1 
ATOM 1384 C CG  . ASP B 1 29  ? -24.204 8.469   153.828 1.00 100.28 ? 29  ASP B CG  1 
ATOM 1385 O OD1 . ASP B 1 29  ? -24.257 9.683   154.125 1.00 100.28 ? 29  ASP B OD1 1 
ATOM 1386 O OD2 . ASP B 1 29  ? -23.567 7.632   154.499 1.00 100.28 ? 29  ASP B OD2 1 
ATOM 1387 N N   . LEU B 1 30  ? -27.575 7.325   150.974 1.00 94.22  ? 30  LEU B N   1 
ATOM 1388 C CA  . LEU B 1 30  ? -28.116 6.829   149.715 1.00 94.22  ? 30  LEU B CA  1 
ATOM 1389 C C   . LEU B 1 30  ? -29.208 7.739   149.171 1.00 94.22  ? 30  LEU B C   1 
ATOM 1390 O O   . LEU B 1 30  ? -29.281 7.968   147.959 1.00 94.22  ? 30  LEU B O   1 
ATOM 1391 C CB  . LEU B 1 30  ? -28.652 5.412   149.909 1.00 94.22  ? 30  LEU B CB  1 
ATOM 1392 C CG  . LEU B 1 30  ? -27.584 4.348   150.155 1.00 94.22  ? 30  LEU B CG  1 
ATOM 1393 C CD1 . LEU B 1 30  ? -28.202 3.110   150.777 1.00 94.22  ? 30  LEU B CD1 1 
ATOM 1394 C CD2 . LEU B 1 30  ? -26.872 3.996   148.861 1.00 94.22  ? 30  LEU B CD2 1 
ATOM 1395 N N   . LEU B 1 31  ? -30.050 8.293   150.044 1.00 94.63  ? 31  LEU B N   1 
ATOM 1396 C CA  . LEU B 1 31  ? -31.034 9.262   149.576 1.00 94.63  ? 31  LEU B CA  1 
ATOM 1397 C C   . LEU B 1 31  ? -30.374 10.543  149.077 1.00 94.63  ? 31  LEU B C   1 
ATOM 1398 O O   . LEU B 1 31  ? -30.757 11.071  148.025 1.00 94.63  ? 31  LEU B O   1 
ATOM 1399 C CB  . LEU B 1 31  ? -32.034 9.577   150.689 1.00 94.63  ? 31  LEU B CB  1 
ATOM 1400 C CG  . LEU B 1 31  ? -33.004 8.456   151.075 1.00 94.63  ? 31  LEU B CG  1 
ATOM 1401 C CD1 . LEU B 1 31  ? -33.778 8.840   152.322 1.00 94.63  ? 31  LEU B CD1 1 
ATOM 1402 C CD2 . LEU B 1 31  ? -33.964 8.130   149.940 1.00 94.63  ? 31  LEU B CD2 1 
ATOM 1403 N N   . ASP B 1 32  ? -29.347 11.029  149.782 1.00 98.26  ? 32  ASP B N   1 
ATOM 1404 C CA  . ASP B 1 32  ? -28.592 12.172  149.276 1.00 98.26  ? 32  ASP B CA  1 
ATOM 1405 C C   . ASP B 1 32  ? -28.018 11.892  147.892 1.00 98.26  ? 32  ASP B C   1 
ATOM 1406 O O   . ASP B 1 32  ? -28.145 12.716  146.981 1.00 98.26  ? 32  ASP B O   1 
ATOM 1407 C CB  . ASP B 1 32  ? -27.481 12.538  150.258 1.00 98.26  ? 32  ASP B CB  1 
ATOM 1408 C CG  . ASP B 1 32  ? -28.004 13.262  151.482 1.00 98.26  ? 32  ASP B CG  1 
ATOM 1409 O OD1 . ASP B 1 32  ? -29.226 13.510  151.553 1.00 98.26  ? 32  ASP B OD1 1 
ATOM 1410 O OD2 . ASP B 1 32  ? -27.195 13.580  152.379 1.00 98.26  ? 32  ASP B OD2 1 
ATOM 1411 N N   . THR B 1 33  ? -27.369 10.741  147.722 1.00 96.76  ? 33  THR B N   1 
ATOM 1412 C CA  . THR B 1 33  ? -26.737 10.418  146.446 1.00 96.76  ? 33  THR B CA  1 
ATOM 1413 C C   . THR B 1 33  ? -27.766 10.303  145.325 1.00 96.76  ? 33  THR B C   1 
ATOM 1414 O O   . THR B 1 33  ? -27.598 10.887  144.246 1.00 96.76  ? 33  THR B O   1 
ATOM 1415 C CB  . THR B 1 33  ? -25.942 9.116   146.576 1.00 96.76  ? 33  THR B CB  1 
ATOM 1416 O OG1 . THR B 1 33  ? -25.058 9.204   147.700 1.00 96.76  ? 33  THR B OG1 1 
ATOM 1417 C CG2 . THR B 1 33  ? -25.126 8.858   145.319 1.00 96.76  ? 33  THR B CG2 1 
ATOM 1418 N N   . ALA B 1 34  ? -28.821 9.520   145.553 1.00 97.17  ? 34  ALA B N   1 
ATOM 1419 C CA  . ALA B 1 34  ? -29.887 9.374   144.568 1.00 97.17  ? 34  ALA B CA  1 
ATOM 1420 C C   . ALA B 1 34  ? -30.481 10.714  144.160 1.00 97.17  ? 34  ALA B C   1 
ATOM 1421 O O   . ALA B 1 34  ? -30.661 10.979  142.965 1.00 97.17  ? 34  ALA B O   1 
ATOM 1422 C CB  . ALA B 1 34  ? -30.978 8.456   145.116 1.00 97.17  ? 34  ALA B CB  1 
ATOM 1423 N N   . SER B 1 35  ? -30.701 11.613  145.119 1.00 100.20 ? 35  SER B N   1 
ATOM 1424 C CA  . SER B 1 35  ? -31.219 12.927  144.758 1.00 100.20 ? 35  SER B CA  1 
ATOM 1425 C C   . SER B 1 35  ? -30.207 13.713  143.940 1.00 100.20 ? 35  SER B C   1 
ATOM 1426 O O   . SER B 1 35  ? -30.492 14.096  142.798 1.00 100.20 ? 35  SER B O   1 
ATOM 1427 C CB  . SER B 1 35  ? -31.579 13.699  146.023 1.00 100.20 ? 35  SER B CB  1 
ATOM 1428 O OG  . SER B 1 35  ? -32.218 14.921  145.702 1.00 100.20 ? 35  SER B OG  1 
ATOM 1429 N N   . ALA B 1 36  ? -28.979 13.823  144.452 1.00 95.91  ? 36  ALA B N   1 
ATOM 1430 C CA  . ALA B 1 36  ? -27.949 14.650  143.836 1.00 95.91  ? 36  ALA B CA  1 
ATOM 1431 C C   . ALA B 1 36  ? -27.637 14.208  142.417 1.00 95.91  ? 36  ALA B C   1 
ATOM 1432 O O   . ALA B 1 36  ? -27.289 15.043  141.575 1.00 95.91  ? 36  ALA B O   1 
ATOM 1433 C CB  . ALA B 1 36  ? -26.680 14.617  144.687 1.00 95.91  ? 36  ALA B CB  1 
ATOM 1434 N N   . LEU B 1 37  ? -27.756 12.917  142.124 1.00 98.22  ? 37  LEU B N   1 
ATOM 1435 C CA  . LEU B 1 37  ? -27.444 12.442  140.783 1.00 98.22  ? 37  LEU B CA  1 
ATOM 1436 C C   . LEU B 1 37  ? -28.650 12.347  139.858 1.00 98.22  ? 37  LEU B C   1 
ATOM 1437 O O   . LEU B 1 37  ? -28.471 12.485  138.645 1.00 98.22  ? 37  LEU B O   1 
ATOM 1438 C CB  . LEU B 1 37  ? -26.757 11.073  140.852 1.00 98.22  ? 37  LEU B CB  1 
ATOM 1439 C CG  . LEU B 1 37  ? -25.247 11.127  141.103 1.00 98.22  ? 37  LEU B CG  1 
ATOM 1440 C CD1 . LEU B 1 37  ? -24.939 11.688  142.479 1.00 98.22  ? 37  LEU B CD1 1 
ATOM 1441 C CD2 . LEU B 1 37  ? -24.610 9.755   140.932 1.00 98.22  ? 37  LEU B CD2 1 
ATOM 1442 N N   . TYR B 1 38  ? -29.874 12.124  140.359 1.00 99.52  ? 38  TYR B N   1 
ATOM 1443 C CA  . TYR B 1 38  ? -30.939 11.722  139.448 1.00 99.52  ? 38  TYR B CA  1 
ATOM 1444 C C   . TYR B 1 38  ? -32.281 12.403  139.692 1.00 99.52  ? 38  TYR B C   1 
ATOM 1445 O O   . TYR B 1 38  ? -33.235 12.081  138.980 1.00 99.52  ? 38  TYR B O   1 
ATOM 1446 C CB  . TYR B 1 38  ? -31.125 10.200  139.506 1.00 99.52  ? 38  TYR B CB  1 
ATOM 1447 C CG  . TYR B 1 38  ? -29.852 9.430   139.245 1.00 99.52  ? 38  TYR B CG  1 
ATOM 1448 C CD1 . TYR B 1 38  ? -29.255 9.455   137.993 1.00 99.52  ? 38  TYR B CD1 1 
ATOM 1449 C CD2 . TYR B 1 38  ? -29.241 8.694   140.248 1.00 99.52  ? 38  TYR B CD2 1 
ATOM 1450 C CE1 . TYR B 1 38  ? -28.096 8.753   137.742 1.00 99.52  ? 38  TYR B CE1 1 
ATOM 1451 C CE2 . TYR B 1 38  ? -28.071 8.000   140.009 1.00 99.52  ? 38  TYR B CE2 1 
ATOM 1452 C CZ  . TYR B 1 38  ? -27.504 8.033   138.754 1.00 99.52  ? 38  TYR B CZ  1 
ATOM 1453 O OH  . TYR B 1 38  ? -26.343 7.342   138.505 1.00 99.52  ? 38  TYR B OH  1 
ATOM 1454 N N   . ARG B 1 39  ? -32.372 13.397  140.584 1.00 105.83 ? 39  ARG B N   1 
ATOM 1455 C CA  . ARG B 1 39  ? -33.671 13.996  140.894 1.00 105.83 ? 39  ARG B CA  1 
ATOM 1456 C C   . ARG B 1 39  ? -34.461 14.383  139.641 1.00 105.83 ? 39  ARG B C   1 
ATOM 1457 O O   . ARG B 1 39  ? -35.651 14.064  139.524 1.00 105.83 ? 39  ARG B O   1 
ATOM 1458 C CB  . ARG B 1 39  ? -33.490 15.199  141.822 1.00 105.83 ? 39  ARG B CB  1 
ATOM 1459 C CG  . ARG B 1 39  ? -34.814 15.843  142.220 1.00 105.83 ? 39  ARG B CG  1 
ATOM 1460 C CD  . ARG B 1 39  ? -34.657 17.073  143.091 1.00 105.83 ? 39  ARG B CD  1 
ATOM 1461 N NE  . ARG B 1 39  ? -34.142 16.712  144.406 1.00 105.83 ? 39  ARG B NE  1 
ATOM 1462 C CZ  . ARG B 1 39  ? -33.748 17.578  145.329 1.00 105.83 ? 39  ARG B CZ  1 
ATOM 1463 N NH1 . ARG B 1 39  ? -33.822 18.884  145.131 1.00 105.83 ? 39  ARG B NH1 1 
ATOM 1464 N NH2 . ARG B 1 39  ? -33.269 17.119  146.483 1.00 105.83 ? 39  ARG B NH2 1 
ATOM 1465 N N   . GLU B 1 40  ? -33.820 15.066  138.689 1.00 109.31 ? 40  GLU B N   1 
ATOM 1466 C CA  . GLU B 1 40  ? -34.537 15.490  137.485 1.00 109.31 ? 40  GLU B CA  1 
ATOM 1467 C C   . GLU B 1 40  ? -35.015 14.300  136.658 1.00 109.31 ? 40  GLU B C   1 
ATOM 1468 O O   . GLU B 1 40  ? -36.148 14.303  136.163 1.00 109.31 ? 40  GLU B O   1 
ATOM 1469 C CB  . GLU B 1 40  ? -33.651 16.402  136.639 1.00 109.31 ? 40  GLU B CB  1 
ATOM 1470 C CG  . GLU B 1 40  ? -33.312 17.723  137.305 1.00 109.31 ? 40  GLU B CG  1 
ATOM 1471 C CD  . GLU B 1 40  ? -32.709 18.723  136.338 1.00 109.31 ? 40  GLU B CD  1 
ATOM 1472 O OE1 . GLU B 1 40  ? -32.342 18.318  135.216 1.00 109.31 ? 40  GLU B OE1 1 
ATOM 1473 O OE2 . GLU B 1 40  ? -32.609 19.914  136.700 1.00 109.31 ? 40  GLU B OE2 1 
ATOM 1474 N N   . ALA B 1 41  ? -34.177 13.278  136.494 1.00 101.48 ? 41  ALA B N   1 
ATOM 1475 C CA  . ALA B 1 41  ? -34.580 12.107  135.719 1.00 101.48 ? 41  ALA B CA  1 
ATOM 1476 C C   . ALA B 1 41  ? -35.731 11.371  136.396 1.00 101.48 ? 41  ALA B C   1 
ATOM 1477 O O   . ALA B 1 41  ? -36.681 10.940  135.734 1.00 101.48 ? 41  ALA B O   1 
ATOM 1478 C CB  . ALA B 1 41  ? -33.387 11.176  135.518 1.00 101.48 ? 41  ALA B CB  1 
ATOM 1479 N N   . LEU B 1 42  ? -35.658 11.227  137.718 1.00 99.08  ? 42  LEU B N   1 
ATOM 1480 C CA  . LEU B 1 42  ? -36.723 10.582  138.477 1.00 99.08  ? 42  LEU B CA  1 
ATOM 1481 C C   . LEU B 1 42  ? -38.037 11.339  138.342 1.00 99.08  ? 42  LEU B C   1 
ATOM 1482 O O   . LEU B 1 42  ? -39.097 10.730  138.162 1.00 99.08  ? 42  LEU B O   1 
ATOM 1483 C CB  . LEU B 1 42  ? -36.320 10.472  139.947 1.00 99.08  ? 42  LEU B CB  1 
ATOM 1484 C CG  . LEU B 1 42  ? -35.221 9.458   140.273 1.00 99.08  ? 42  LEU B CG  1 
ATOM 1485 C CD1 . LEU B 1 42  ? -34.732 9.646   141.697 1.00 99.08  ? 42  LEU B CD1 1 
ATOM 1486 C CD2 . LEU B 1 42  ? -35.709 8.038   140.056 1.00 99.08  ? 42  LEU B CD2 1 
ATOM 1487 N N   . GLU B 1 43  ? -37.991 12.667  138.431 1.00 106.47 ? 43  GLU B N   1 
ATOM 1488 C CA  . GLU B 1 43  ? -39.196 13.479  138.302 1.00 106.47 ? 43  GLU B CA  1 
ATOM 1489 C C   . GLU B 1 43  ? -39.705 13.602  136.867 1.00 106.47 ? 43  GLU B C   1 
ATOM 1490 O O   . GLU B 1 43  ? -40.878 13.934  136.675 1.00 106.47 ? 43  GLU B O   1 
ATOM 1491 C CB  . GLU B 1 43  ? -38.934 14.879  138.857 1.00 106.47 ? 43  GLU B CB  1 
ATOM 1492 C CG  . GLU B 1 43  ? -38.738 14.919  140.360 1.00 106.47 ? 43  GLU B CG  1 
ATOM 1493 C CD  . GLU B 1 43  ? -38.504 16.322  140.878 1.00 106.47 ? 43  GLU B CD  1 
ATOM 1494 O OE1 . GLU B 1 43  ? -38.375 17.249  140.050 1.00 106.47 ? 43  GLU B OE1 1 
ATOM 1495 O OE2 . GLU B 1 43  ? -38.435 16.499  142.111 1.00 106.47 ? 43  GLU B OE2 1 
ATOM 1496 N N   . SER B 1 44  ? -38.877 13.246  135.883 1.00 104.87 ? 44  SER B N   1 
ATOM 1497 C CA  . SER B 1 44  ? -39.300 13.221  134.461 1.00 104.87 ? 44  SER B CA  1 
ATOM 1498 C C   . SER B 1 44  ? -40.505 12.281  134.341 1.00 104.87 ? 44  SER B C   1 
ATOM 1499 O O   . SER B 1 44  ? -40.538 11.279  135.084 1.00 104.87 ? 44  SER B O   1 
ATOM 1500 C CB  . SER B 1 44  ? -38.168 12.786  133.570 1.00 104.87 ? 44  SER B CB  1 
ATOM 1501 O OG  . SER B 1 44  ? -37.778 11.450  133.850 1.00 104.87 ? 44  SER B OG  1 
ATOM 1502 N N   . PRO B 1 45  ? -41.487 12.537  133.449 1.00 102.81 ? 45  PRO B N   1 
ATOM 1503 C CA  . PRO B 1 45  ? -42.680 11.702  133.336 1.00 102.81 ? 45  PRO B CA  1 
ATOM 1504 C C   . PRO B 1 45  ? -42.390 10.562  132.361 1.00 102.81 ? 45  PRO B C   1 
ATOM 1505 O O   . PRO B 1 45  ? -43.328 9.907   131.947 1.00 102.81 ? 45  PRO B O   1 
ATOM 1506 C CB  . PRO B 1 45  ? -43.740 12.643  132.753 1.00 102.81 ? 45  PRO B CB  1 
ATOM 1507 C CG  . PRO B 1 45  ? -42.942 13.661  131.954 1.00 102.81 ? 45  PRO B CG  1 
ATOM 1508 C CD  . PRO B 1 45  ? -41.520 13.632  132.482 1.00 102.81 ? 45  PRO B CD  1 
ATOM 1509 N N   . GLU B 1 46  ? -41.117 10.345  132.031 1.00 106.97 ? 46  GLU B N   1 
ATOM 1510 C CA  . GLU B 1 46  ? -40.728 9.343   131.011 1.00 106.97 ? 46  GLU B CA  1 
ATOM 1511 C C   . GLU B 1 46  ? -40.202 8.067   131.659 1.00 106.97 ? 46  GLU B C   1 
ATOM 1512 O O   . GLU B 1 46  ? -39.555 8.180   132.716 1.00 106.97 ? 46  GLU B O   1 
ATOM 1513 C CB  . GLU B 1 46  ? -39.653 9.935   130.097 1.00 106.97 ? 46  GLU B CB  1 
ATOM 1514 C CG  . GLU B 1 46  ? -40.150 11.079  129.230 1.00 106.97 ? 46  GLU B CG  1 
ATOM 1515 C CD  . GLU B 1 46  ? -39.084 11.729  128.367 1.00 106.97 ? 46  GLU B CD  1 
ATOM 1516 O OE1 . GLU B 1 46  ? -37.894 11.420  128.568 1.00 106.97 ? 46  GLU B OE1 1 
ATOM 1517 O OE2 . GLU B 1 46  ? -39.448 12.547  127.500 1.00 106.97 ? 46  GLU B OE2 1 
ATOM 1518 N N   . HIS B 1 47  ? -40.502 6.907   131.075 1.00 102.63 ? 47  HIS B N   1 
ATOM 1519 C CA  . HIS B 1 47  ? -39.967 5.614   131.495 1.00 102.63 ? 47  HIS B CA  1 
ATOM 1520 C C   . HIS B 1 47  ? -38.505 5.538   131.073 1.00 102.63 ? 47  HIS B C   1 
ATOM 1521 O O   . HIS B 1 47  ? -38.136 4.885   130.095 1.00 102.63 ? 47  HIS B O   1 
ATOM 1522 C CB  . HIS B 1 47  ? -40.775 4.471   130.892 1.00 102.63 ? 47  HIS B CB  1 
ATOM 1523 C CG  . HIS B 1 47  ? -42.239 4.535   131.189 1.00 102.63 ? 47  HIS B CG  1 
ATOM 1524 N ND1 . HIS B 1 47  ? -42.738 4.546   132.474 1.00 102.63 ? 47  HIS B ND1 1 
ATOM 1525 C CD2 . HIS B 1 47  ? -43.315 4.511   130.368 1.00 102.63 ? 47  HIS B CD2 1 
ATOM 1526 C CE1 . HIS B 1 47  ? -44.058 4.554   132.431 1.00 102.63 ? 47  HIS B CE1 1 
ATOM 1527 N NE2 . HIS B 1 47  ? -44.434 4.547   131.165 1.00 102.63 ? 47  HIS B NE2 1 
ATOM 1528 N N   . CYS B 1 48  ? -37.654 6.230   131.830 1.00 100.66 ? 48  CYS B N   1 
ATOM 1529 C CA  . CYS B 1 48  ? -36.246 6.280   131.460 1.00 100.66 ? 48  CYS B CA  1 
ATOM 1530 C C   . CYS B 1 48  ? -35.623 4.891   131.517 1.00 100.66 ? 48  CYS B C   1 
ATOM 1531 O O   . CYS B 1 48  ? -34.885 4.497   130.606 1.00 100.66 ? 48  CYS B O   1 
ATOM 1532 C CB  . CYS B 1 48  ? -35.500 7.246   132.378 1.00 100.66 ? 48  CYS B CB  1 
ATOM 1533 S SG  . CYS B 1 48  ? -36.061 8.958   132.253 1.00 100.66 ? 48  CYS B SG  1 
ATOM 1534 N N   . SER B 1 49  ? -35.908 4.134   132.568 1.00 97.99  ? 49  SER B N   1 
ATOM 1535 C CA  . SER B 1 49  ? -35.522 2.732   132.631 1.00 97.99  ? 49  SER B CA  1 
ATOM 1536 C C   . SER B 1 49  ? -36.295 2.065   133.770 1.00 97.99  ? 49  SER B C   1 
ATOM 1537 O O   . SER B 1 49  ? -36.824 2.753   134.646 1.00 97.99  ? 49  SER B O   1 
ATOM 1538 C CB  . SER B 1 49  ? -34.007 2.581   132.848 1.00 97.99  ? 49  SER B CB  1 
ATOM 1539 O OG  . SER B 1 49  ? -33.641 2.967   134.160 1.00 97.99  ? 49  SER B OG  1 
ATOM 1540 N N   . PRO B 1 50  ? -36.367 0.732   133.770 1.00 94.13  ? 50  PRO B N   1 
ATOM 1541 C CA  . PRO B 1 50  ? -36.980 0.016   134.905 1.00 94.13  ? 50  PRO B CA  1 
ATOM 1542 C C   . PRO B 1 50  ? -36.343 0.316   136.253 1.00 94.13  ? 50  PRO B C   1 
ATOM 1543 O O   . PRO B 1 50  ? -37.032 0.294   137.285 1.00 94.13  ? 50  PRO B O   1 
ATOM 1544 C CB  . PRO B 1 50  ? -36.816 -1.462  134.515 1.00 94.13  ? 50  PRO B CB  1 
ATOM 1545 C CG  . PRO B 1 50  ? -35.742 -1.482  133.483 1.00 94.13  ? 50  PRO B CG  1 
ATOM 1546 C CD  . PRO B 1 50  ? -35.910 -0.202  132.731 1.00 94.13  ? 50  PRO B CD  1 
ATOM 1547 N N   . HIS B 1 51  ? -35.042 0.609   136.266 1.00 92.68  ? 51  HIS B N   1 
ATOM 1548 C CA  . HIS B 1 51  ? -34.378 1.065   137.483 1.00 92.68  ? 51  HIS B CA  1 
ATOM 1549 C C   . HIS B 1 51  ? -35.027 2.318   138.058 1.00 92.68  ? 51  HIS B C   1 
ATOM 1550 O O   . HIS B 1 51  ? -35.225 2.417   139.277 1.00 92.68  ? 51  HIS B O   1 
ATOM 1551 C CB  . HIS B 1 51  ? -32.905 1.341   137.182 1.00 92.68  ? 51  HIS B CB  1 
ATOM 1552 C CG  . HIS B 1 51  ? -32.140 0.136   136.733 1.00 92.68  ? 51  HIS B CG  1 
ATOM 1553 N ND1 . HIS B 1 51  ? -31.855 -0.924  137.567 1.00 92.68  ? 51  HIS B ND1 1 
ATOM 1554 C CD2 . HIS B 1 51  ? -31.599 -0.176  135.532 1.00 92.68  ? 51  HIS B CD2 1 
ATOM 1555 C CE1 . HIS B 1 51  ? -31.169 -1.834  136.899 1.00 92.68  ? 51  HIS B CE1 1 
ATOM 1556 N NE2 . HIS B 1 51  ? -31.006 -1.408  135.661 1.00 92.68  ? 51  HIS B NE2 1 
ATOM 1557 N N   . HIS B 1 52  ? -35.377 3.280   137.206 1.00 94.79  ? 52  HIS B N   1 
ATOM 1558 C CA  . HIS B 1 52  ? -36.050 4.477   137.700 1.00 94.79  ? 52  HIS B CA  1 
ATOM 1559 C C   . HIS B 1 52  ? -37.394 4.145   138.340 1.00 94.79  ? 52  HIS B C   1 
ATOM 1560 O O   . HIS B 1 52  ? -37.732 4.685   139.400 1.00 94.79  ? 52  HIS B O   1 
ATOM 1561 C CB  . HIS B 1 52  ? -36.243 5.468   136.553 1.00 94.79  ? 52  HIS B CB  1 
ATOM 1562 C CG  . HIS B 1 52  ? -34.964 6.026   136.013 1.00 94.79  ? 52  HIS B CG  1 
ATOM 1563 N ND1 . HIS B 1 52  ? -34.181 5.345   135.107 1.00 94.79  ? 52  HIS B ND1 1 
ATOM 1564 C CD2 . HIS B 1 52  ? -34.329 7.198   136.252 1.00 94.79  ? 52  HIS B CD2 1 
ATOM 1565 C CE1 . HIS B 1 52  ? -33.118 6.072   134.811 1.00 94.79  ? 52  HIS B CE1 1 
ATOM 1566 N NE2 . HIS B 1 52  ? -33.186 7.202   135.490 1.00 94.79  ? 52  HIS B NE2 1 
ATOM 1567 N N   . THR B 1 53  ? -38.175 3.265   137.714 1.00 92.38  ? 53  THR B N   1 
ATOM 1568 C CA  . THR B 1 53  ? -39.475 2.902   138.274 1.00 92.38  ? 53  THR B CA  1 
ATOM 1569 C C   . THR B 1 53  ? -39.336 2.197   139.621 1.00 92.38  ? 53  THR B C   1 
ATOM 1570 O O   . THR B 1 53  ? -40.071 2.499   140.575 1.00 92.38  ? 53  THR B O   1 
ATOM 1571 C CB  . THR B 1 53  ? -40.227 2.013   137.281 1.00 92.38  ? 53  THR B CB  1 
ATOM 1572 O OG1 . THR B 1 53  ? -40.477 2.744   136.076 1.00 92.38  ? 53  THR B OG1 1 
ATOM 1573 C CG2 . THR B 1 53  ? -41.553 1.544   137.860 1.00 92.38  ? 53  THR B CG2 1 
ATOM 1574 N N   . ALA B 1 54  ? -38.373 1.279   139.731 1.00 91.32  ? 54  ALA B N   1 
ATOM 1575 C CA  . ALA B 1 54  ? -38.131 0.623   141.012 1.00 91.32  ? 54  ALA B CA  1 
ATOM 1576 C C   . ALA B 1 54  ? -37.700 1.614   142.088 1.00 91.32  ? 54  ALA B C   1 
ATOM 1577 O O   . ALA B 1 54  ? -38.169 1.540   143.233 1.00 91.32  ? 54  ALA B O   1 
ATOM 1578 C CB  . ALA B 1 54  ? -37.076 -0.469  140.840 1.00 91.32  ? 54  ALA B CB  1 
ATOM 1579 N N   . LEU B 1 55  ? -36.805 2.543   141.748 1.00 92.59  ? 55  LEU B N   1 
ATOM 1580 C CA  . LEU B 1 55  ? -36.402 3.557   142.717 1.00 92.59  ? 55  LEU B CA  1 
ATOM 1581 C C   . LEU B 1 55  ? -37.582 4.412   143.169 1.00 92.59  ? 55  LEU B C   1 
ATOM 1582 O O   . LEU B 1 55  ? -37.717 4.718   144.360 1.00 92.59  ? 55  LEU B O   1 
ATOM 1583 C CB  . LEU B 1 55  ? -35.309 4.435   142.111 1.00 92.59  ? 55  LEU B CB  1 
ATOM 1584 C CG  . LEU B 1 55  ? -33.934 3.777   142.001 1.00 92.59  ? 55  LEU B CG  1 
ATOM 1585 C CD1 . LEU B 1 55  ? -33.033 4.585   141.084 1.00 92.59  ? 55  LEU B CD1 1 
ATOM 1586 C CD2 . LEU B 1 55  ? -33.299 3.614   143.371 1.00 92.59  ? 55  LEU B CD2 1 
ATOM 1587 N N   . ARG B 1 56  ? -38.426 4.833   142.226 1.00 93.75  ? 56  ARG B N   1 
ATOM 1588 C CA  . ARG B 1 56  ? -39.640 5.573   142.562 1.00 93.75  ? 56  ARG B CA  1 
ATOM 1589 C C   . ARG B 1 56  ? -40.508 4.827   143.573 1.00 93.75  ? 56  ARG B C   1 
ATOM 1590 O O   . ARG B 1 56  ? -40.928 5.388   144.601 1.00 93.75  ? 56  ARG B O   1 
ATOM 1591 C CB  . ARG B 1 56  ? -40.425 5.840   141.277 1.00 93.75  ? 56  ARG B CB  1 
ATOM 1592 C CG  . ARG B 1 56  ? -39.783 6.877   140.368 1.00 93.75  ? 56  ARG B CG  1 
ATOM 1593 C CD  . ARG B 1 56  ? -40.413 6.883   138.983 1.00 93.75  ? 56  ARG B CD  1 
ATOM 1594 N NE  . ARG B 1 56  ? -39.829 7.911   138.129 1.00 93.75  ? 56  ARG B NE  1 
ATOM 1595 C CZ  . ARG B 1 56  ? -39.615 7.785   136.825 1.00 93.75  ? 56  ARG B CZ  1 
ATOM 1596 N NH1 . ARG B 1 56  ? -39.963 6.693   136.166 1.00 93.75  ? 56  ARG B NH1 1 
ATOM 1597 N NH2 . ARG B 1 56  ? -39.089 8.805   136.154 1.00 93.75  ? 56  ARG B NH2 1 
ATOM 1598 N N   . GLN B 1 57  ? -40.855 3.571   143.320 1.00 94.63  ? 57  GLN B N   1 
ATOM 1599 C CA  . GLN B 1 57  ? -41.775 2.836   144.232 1.00 94.63  ? 57  GLN B CA  1 
ATOM 1600 C C   . GLN B 1 57  ? -41.155 2.782   145.633 1.00 94.63  ? 57  GLN B C   1 
ATOM 1601 O O   . GLN B 1 57  ? -41.835 3.204   146.624 1.00 94.63  ? 57  GLN B O   1 
ATOM 1602 C CB  . GLN B 1 57  ? -42.034 1.425   143.710 1.00 94.63  ? 57  GLN B CB  1 
ATOM 1603 C CG  . GLN B 1 57  ? -42.537 1.371   142.274 1.00 94.63  ? 57  GLN B CG  1 
ATOM 1604 C CD  . GLN B 1 57  ? -43.963 1.838   142.132 1.00 94.63  ? 57  GLN B CD  1 
ATOM 1605 O OE1 . GLN B 1 57  ? -44.278 2.671   141.286 1.00 94.63  ? 57  GLN B OE1 1 
ATOM 1606 N NE2 . GLN B 1 57  ? -44.841 1.297   142.958 1.00 94.63  ? 57  GLN B NE2 1 
ATOM 1607 N N   . ALA B 1 58  ? -39.903 2.347   145.732 1.00 95.09  ? 58  ALA B N   1 
ATOM 1608 C CA  . ALA B 1 58  ? -39.191 2.186   147.019 1.00 95.09  ? 58  ALA B CA  1 
ATOM 1609 C C   . ALA B 1 58  ? -39.189 3.486   147.819 1.00 95.09  ? 58  ALA B C   1 
ATOM 1610 O O   . ALA B 1 58  ? -39.510 3.433   149.025 1.00 95.09  ? 58  ALA B O   1 
ATOM 1611 C CB  . ALA B 1 58  ? -37.790 1.740   146.730 1.00 95.09  ? 58  ALA B CB  1 
ATOM 1612 N N   . ILE B 1 59  ? -38.840 4.607   147.193 1.00 93.62  ? 59  ILE B N   1 
ATOM 1613 C CA  . ILE B 1 59  ? -38.753 5.920   147.893 1.00 93.62  ? 59  ILE B CA  1 
ATOM 1614 C C   . ILE B 1 59  ? -40.111 6.227   148.532 1.00 93.62  ? 59  ILE B C   1 
ATOM 1615 O O   . ILE B 1 59  ? -40.141 6.538   149.752 1.00 93.62  ? 59  ILE B O   1 
ATOM 1616 C CB  . ILE B 1 59  ? -38.300 7.015   146.912 1.00 93.62  ? 59  ILE B CB  1 
ATOM 1617 C CG1 . ILE B 1 59  ? -36.845 6.815   146.483 1.00 93.62  ? 59  ILE B CG1 1 
ATOM 1618 C CG2 . ILE B 1 59  ? -38.528 8.397   147.500 1.00 93.62  ? 59  ILE B CG2 1 
ATOM 1619 C CD1 . ILE B 1 59  ? -36.462 7.584   145.245 1.00 93.62  ? 59  ILE B CD1 1 
ATOM 1620 N N   . LEU B 1 60  ? -41.200 6.102   147.776 1.00 98.70  ? 60  LEU B N   1 
ATOM 1621 C CA  . LEU B 1 60  ? -42.562 6.426   148.278 1.00 98.70  ? 60  LEU B CA  1 
ATOM 1622 C C   . LEU B 1 60  ? -42.906 5.480   149.433 1.00 98.70  ? 60  LEU B C   1 
ATOM 1623 O O   . LEU B 1 60  ? -43.459 5.958   150.470 1.00 98.70  ? 60  LEU B O   1 
ATOM 1624 C CB  . LEU B 1 60  ? -43.553 6.291   147.120 1.00 98.70  ? 60  LEU B CB  1 
ATOM 1625 C CG  . LEU B 1 60  ? -43.360 7.266   145.960 1.00 98.70  ? 60  LEU B CG  1 
ATOM 1626 C CD1 . LEU B 1 60  ? -44.185 6.846   144.756 1.00 98.70  ? 60  LEU B CD1 1 
ATOM 1627 C CD2 . LEU B 1 60  ? -43.714 8.680   146.378 1.00 98.70  ? 60  LEU B CD2 1 
ATOM 1628 N N   . CYS B 1 61  ? -42.579 4.197   149.297 1.00 101.12 ? 61  CYS B N   1 
ATOM 1629 C CA  . CYS B 1 61  ? -42.818 3.200   150.376 1.00 101.12 ? 61  CYS B CA  1 
ATOM 1630 C C   . CYS B 1 61  ? -42.107 3.632   151.663 1.00 101.12 ? 61  CYS B C   1 
ATOM 1631 O O   . CYS B 1 61  ? -42.751 3.610   152.751 1.00 101.12 ? 61  CYS B O   1 
ATOM 1632 C CB  . CYS B 1 61  ? -42.325 1.823   149.961 1.00 101.12 ? 61  CYS B CB  1 
ATOM 1633 S SG  . CYS B 1 61  ? -42.188 0.673   151.351 1.00 101.12 ? 61  CYS B SG  1 
ATOM 1634 N N   . TRP B 1 62  ? -40.837 4.019   151.570 1.00 97.99  ? 62  TRP B N   1 
ATOM 1635 C CA  . TRP B 1 62  ? -40.047 4.424   152.762 1.00 97.99  ? 62  TRP B CA  1 
ATOM 1636 C C   . TRP B 1 62  ? -40.672 5.682   153.356 1.00 97.99  ? 62  TRP B C   1 
ATOM 1637 O O   . TRP B 1 62  ? -40.740 5.776   154.591 1.00 97.99  ? 62  TRP B O   1 
ATOM 1638 C CB  . TRP B 1 62  ? -38.569 4.629   152.423 1.00 97.99  ? 62  TRP B CB  1 
ATOM 1639 C CG  . TRP B 1 62  ? -37.737 4.959   153.622 1.00 97.99  ? 62  TRP B CG  1 
ATOM 1640 C CD1 . TRP B 1 62  ? -37.263 6.185   153.982 1.00 97.99  ? 62  TRP B CD1 1 
ATOM 1641 C CD2 . TRP B 1 62  ? -37.304 4.045   154.645 1.00 97.99  ? 62  TRP B CD2 1 
ATOM 1642 N NE1 . TRP B 1 62  ? -36.555 6.096   155.150 1.00 97.99  ? 62  TRP B NE1 1 
ATOM 1643 C CE2 . TRP B 1 62  ? -36.563 4.796   155.580 1.00 97.99  ? 62  TRP B CE2 1 
ATOM 1644 C CE3 . TRP B 1 62  ? -37.463 2.673   154.857 1.00 97.99  ? 62  TRP B CE3 1 
ATOM 1645 C CZ2 . TRP B 1 62  ? -35.985 4.216   156.706 1.00 97.99  ? 62  TRP B CZ2 1 
ATOM 1646 C CZ3 . TRP B 1 62  ? -36.892 2.100   155.970 1.00 97.99  ? 62  TRP B CZ3 1 
ATOM 1647 C CH2 . TRP B 1 62  ? -36.163 2.863   156.881 1.00 97.99  ? 62  TRP B CH2 1 
ATOM 1648 N N   . GLY B 1 63  ? -41.125 6.609   152.517 1.00 100.65 ? 63  GLY B N   1 
ATOM 1649 C CA  . GLY B 1 63  ? -41.812 7.815   153.011 1.00 100.65 ? 63  GLY B CA  1 
ATOM 1650 C C   . GLY B 1 63  ? -43.014 7.434   153.852 1.00 100.65 ? 63  GLY B C   1 
ATOM 1651 O O   . GLY B 1 63  ? -43.151 7.954   154.982 1.00 100.65 ? 63  GLY B O   1 
ATOM 1652 N N   . GLU B 1 64  ? -43.845 6.526   153.345 1.00 103.70 ? 64  GLU B N   1 
ATOM 1653 C CA  . GLU B 1 64  ? -45.048 6.068   154.084 1.00 103.70 ? 64  GLU B CA  1 
ATOM 1654 C C   . GLU B 1 64  ? -44.633 5.413   155.407 1.00 103.70 ? 64  GLU B C   1 
ATOM 1655 O O   . GLU B 1 64  ? -45.310 5.668   156.420 1.00 103.70 ? 64  GLU B O   1 
ATOM 1656 C CB  . GLU B 1 64  ? -45.861 5.112   153.218 1.00 103.70 ? 64  GLU B CB  1 
ATOM 1657 C CG  . GLU B 1 64  ? -46.499 5.787   152.020 1.00 103.70 ? 64  GLU B CG  1 
ATOM 1658 C CD  . GLU B 1 64  ? -47.561 6.814   152.370 1.00 103.70 ? 64  GLU B CD  1 
ATOM 1659 O OE1 . GLU B 1 64  ? -48.122 6.727   153.480 1.00 103.70 ? 64  GLU B OE1 1 
ATOM 1660 O OE2 . GLU B 1 64  ? -47.821 7.701   151.535 1.00 103.70 ? 64  GLU B OE2 1 
ATOM 1661 N N   . LEU B 1 65  ? -43.576 4.597   155.408 1.00 104.40 ? 65  LEU B N   1 
ATOM 1662 C CA  . LEU B 1 65  ? -43.087 3.929   156.646 1.00 104.40 ? 65  LEU B CA  1 
ATOM 1663 C C   . LEU B 1 65  ? -42.655 4.984   157.667 1.00 104.40 ? 65  LEU B C   1 
ATOM 1664 O O   . LEU B 1 65  ? -42.943 4.796   158.861 1.00 104.40 ? 65  LEU B O   1 
ATOM 1665 C CB  . LEU B 1 65  ? -41.915 3.008   156.308 1.00 104.40 ? 65  LEU B CB  1 
ATOM 1666 C CG  . LEU B 1 65  ? -42.266 1.715   155.581 1.00 104.40 ? 65  LEU B CG  1 
ATOM 1667 C CD1 . LEU B 1 65  ? -41.003 1.011   155.115 1.00 104.40 ? 65  LEU B CD1 1 
ATOM 1668 C CD2 . LEU B 1 65  ? -43.091 0.802   156.472 1.00 104.40 ? 65  LEU B CD2 1 
ATOM 1669 N N   . MET B 1 66  ? -41.973 6.040   157.229 1.00 106.58 ? 66  MET B N   1 
ATOM 1670 C CA  . MET B 1 66  ? -41.523 7.140   158.121 1.00 106.58 ? 66  MET B CA  1 
ATOM 1671 C C   . MET B 1 66  ? -42.750 7.865   158.677 1.00 106.58 ? 66  MET B C   1 
ATOM 1672 O O   . MET B 1 66  ? -42.727 8.259   159.874 1.00 106.58 ? 66  MET B O   1 
ATOM 1673 C CB  . MET B 1 66  ? -40.642 8.127   157.353 1.00 106.58 ? 66  MET B CB  1 
ATOM 1674 C CG  . MET B 1 66  ? -39.261 7.587   157.047 1.00 106.58 ? 66  MET B CG  1 
ATOM 1675 S SD  . MET B 1 66  ? -38.419 6.967   158.526 1.00 106.58 ? 66  MET B SD  1 
ATOM 1676 C CE  . MET B 1 66  ? -38.833 5.226   158.426 1.00 106.58 ? 66  MET B CE  1 
ATOM 1677 N N   . THR B 1 67  ? -43.781 8.051   157.854 1.00 107.46 ? 67  THR B N   1 
ATOM 1678 C CA  . THR B 1 67  ? -45.051 8.659   158.322 1.00 107.46 ? 67  THR B CA  1 
ATOM 1679 C C   . THR B 1 67  ? -45.610 7.775   159.433 1.00 107.46 ? 67  THR B C   1 
ATOM 1680 O O   . THR B 1 67  ? -45.999 8.324   160.472 1.00 107.46 ? 67  THR B O   1 
ATOM 1681 C CB  . THR B 1 67  ? -46.062 8.823   157.185 1.00 107.46 ? 67  THR B CB  1 
ATOM 1682 O OG1 . THR B 1 67  ? -45.461 9.601   156.150 1.00 107.46 ? 67  THR B OG1 1 
ATOM 1683 C CG2 . THR B 1 67  ? -47.345 9.482   157.640 1.00 107.46 ? 67  THR B CG2 1 
ATOM 1684 N N   . LEU B 1 68  ? -45.627 6.454   159.231 1.00 109.73 ? 68  LEU B N   1 
ATOM 1685 C CA  . LEU B 1 68  ? -46.121 5.501   160.261 1.00 109.73 ? 68  LEU B CA  1 
ATOM 1686 C C   . LEU B 1 68  ? -45.297 5.674   161.529 1.00 109.73 ? 68  LEU B C   1 
ATOM 1687 O O   . LEU B 1 68  ? -45.894 5.668   162.587 1.00 109.73 ? 68  LEU B O   1 
ATOM 1688 C CB  . LEU B 1 68  ? -46.000 4.058   159.772 1.00 109.73 ? 68  LEU B CB  1 
ATOM 1689 C CG  . LEU B 1 68  ? -46.105 2.991   160.859 1.00 109.73 ? 68  LEU B CG  1 
ATOM 1690 C CD1 . LEU B 1 68  ? -47.450 3.059   161.562 1.00 109.73 ? 68  LEU B CD1 1 
ATOM 1691 C CD2 . LEU B 1 68  ? -45.885 1.607   160.275 1.00 109.73 ? 68  LEU B CD2 1 
ATOM 1692 N N   . ALA B 1 69  ? -43.978 5.789   161.416 1.00 112.71 ? 69  ALA B N   1 
ATOM 1693 C CA  . ALA B 1 69  ? -43.068 5.929   162.575 1.00 112.71 ? 69  ALA B CA  1 
ATOM 1694 C C   . ALA B 1 69  ? -43.393 7.203   163.351 1.00 112.71 ? 69  ALA B C   1 
ATOM 1695 O O   . ALA B 1 69  ? -43.323 7.159   164.584 1.00 112.71 ? 69  ALA B O   1 
ATOM 1696 C CB  . ALA B 1 69  ? -41.645 5.950   162.101 1.00 112.71 ? 69  ALA B CB  1 
ATOM 1697 N N   . THR B 1 70  ? -43.691 8.302   162.659 1.00 114.26 ? 70  THR B N   1 
ATOM 1698 C CA  . THR B 1 70  ? -44.059 9.583   163.316 1.00 114.26 ? 70  THR B CA  1 
ATOM 1699 C C   . THR B 1 70  ? -45.423 9.429   163.983 1.00 114.26 ? 70  THR B C   1 
ATOM 1700 O O   . THR B 1 70  ? -45.588 9.964   165.084 1.00 114.26 ? 70  THR B O   1 
ATOM 1701 C CB  . THR B 1 70  ? -44.065 10.749  162.325 1.00 114.26 ? 70  THR B CB  1 
ATOM 1702 O OG1 . THR B 1 70  ? -42.773 10.833  161.727 1.00 114.26 ? 70  THR B OG1 1 
ATOM 1703 C CG2 . THR B 1 70  ? -44.415 12.065  162.980 1.00 114.26 ? 70  THR B CG2 1 
ATOM 1704 N N   . TRP B 1 71  ? -46.357 8.723   163.346 1.00 117.11 ? 71  TRP B N   1 
ATOM 1705 C CA  . TRP B 1 71  ? -47.720 8.504   163.896 1.00 117.11 ? 71  TRP B CA  1 
ATOM 1706 C C   . TRP B 1 71  ? -47.611 7.687   165.178 1.00 117.11 ? 71  TRP B C   1 
ATOM 1707 O O   . TRP B 1 71  ? -48.099 8.165   166.197 1.00 117.11 ? 71  TRP B O   1 
ATOM 1708 C CB  . TRP B 1 71  ? -48.625 7.813   162.878 1.00 117.11 ? 71  TRP B CB  1 
ATOM 1709 C CG  . TRP B 1 71  ? -50.009 7.539   163.380 1.00 117.11 ? 71  TRP B CG  1 
ATOM 1710 C CD1 . TRP B 1 71  ? -51.113 8.320   163.209 1.00 117.11 ? 71  TRP B CD1 1 
ATOM 1711 C CD2 . TRP B 1 71  ? -50.442 6.393   164.132 1.00 117.11 ? 71  TRP B CD2 1 
ATOM 1712 N NE1 . TRP B 1 71  ? -52.201 7.743   163.805 1.00 117.11 ? 71  TRP B NE1 1 
ATOM 1713 C CE2 . TRP B 1 71  ? -51.821 6.560   164.378 1.00 117.11 ? 71  TRP B CE2 1 
ATOM 1714 C CE3 . TRP B 1 71  ? -49.806 5.248   164.619 1.00 117.11 ? 71  TRP B CE3 1 
ATOM 1715 C CZ2 . TRP B 1 71  ? -52.568 5.624   165.089 1.00 117.11 ? 71  TRP B CZ2 1 
ATOM 1716 C CZ3 . TRP B 1 71  ? -50.545 4.324   165.323 1.00 117.11 ? 71  TRP B CZ3 1 
ATOM 1717 C CH2 . TRP B 1 71  ? -51.907 4.511   165.551 1.00 117.11 ? 71  TRP B CH2 1 
ATOM 1718 N N   . VAL B 1 72  ? -46.998 6.501   165.123 1.00 121.74 ? 72  VAL B N   1 
ATOM 1719 C CA  . VAL B 1 72  ? -46.806 5.692   166.328 1.00 121.74 ? 72  VAL B CA  1 
ATOM 1720 C C   . VAL B 1 72  ? -46.120 6.501   167.424 1.00 121.74 ? 72  VAL B C   1 
ATOM 1721 O O   . VAL B 1 72  ? -46.484 6.413   168.602 1.00 121.74 ? 72  VAL B O   1 
ATOM 1722 C CB  . VAL B 1 72  ? -46.046 4.391   165.997 1.00 121.74 ? 72  VAL B CB  1 
ATOM 1723 C CG1 . VAL B 1 72  ? -44.636 4.667   165.524 1.00 121.74 ? 72  VAL B CG1 1 
ATOM 1724 C CG2 . VAL B 1 72  ? -46.025 3.467   167.200 1.00 121.74 ? 72  VAL B CG2 1 
ATOM 1725 N N   . GLY B 1 73  ? -45.122 7.303   167.051 1.00 122.92 ? 73  GLY B N   1 
ATOM 1726 C CA  . GLY B 1 73  ? -44.430 8.130   168.028 1.00 122.92 ? 73  GLY B CA  1 
ATOM 1727 C C   . GLY B 1 73  ? -45.310 9.143   168.738 1.00 122.92 ? 73  GLY B C   1 
ATOM 1728 O O   . GLY B 1 73  ? -45.114 9.422   169.924 1.00 122.92 ? 73  GLY B O   1 
ATOM 1729 N N   . VAL B 1 74  ? -46.287 9.708   168.032 1.00 126.46 ? 74  VAL B N   1 
ATOM 1730 C CA  . VAL B 1 74  ? -47.277 10.556  168.699 1.00 126.46 ? 74  VAL B CA  1 
ATOM 1731 C C   . VAL B 1 74  ? -48.305 9.777   169.519 1.00 126.46 ? 74  VAL B C   1 
ATOM 1732 O O   . VAL B 1 74  ? -48.513 10.068  170.702 1.00 126.46 ? 74  VAL B O   1 
ATOM 1733 C CB  . VAL B 1 74  ? -48.030 11.425  167.675 1.00 30.00  ? 74  VAL B CB  1 
ATOM 1734 C CG1 . VAL B 1 74  ? -49.120 12.233  168.362 1.00 30.00  ? 74  VAL B CG1 1 
ATOM 1735 C CG2 . VAL B 1 74  ? -47.064 12.338  166.937 1.00 30.00  ? 74  VAL B CG2 1 
ATOM 1736 N N   . ASN B 1 75  ? -48.957 8.790   168.914 1.00 126.44 ? 75  ASN B N   1 
ATOM 1737 C CA  . ASN B 1 75  ? -50.212 8.278   169.463 1.00 126.44 ? 75  ASN B CA  1 
ATOM 1738 C C   . ASN B 1 75  ? -50.048 7.412   170.710 1.00 126.44 ? 75  ASN B C   1 
ATOM 1739 O O   . ASN B 1 75  ? -50.865 7.506   171.634 1.00 126.44 ? 75  ASN B O   1 
ATOM 1740 C CB  . ASN B 1 75  ? -50.962 7.502   168.384 1.00 126.44 ? 75  ASN B CB  1 
ATOM 1741 C CG  . ASN B 1 75  ? -52.387 7.192   168.784 1.00 126.44 ? 75  ASN B CG  1 
ATOM 1742 O OD1 . ASN B 1 75  ? -53.017 7.952   169.519 1.00 126.44 ? 75  ASN B OD1 1 
ATOM 1743 N ND2 . ASN B 1 75  ? -52.898 6.061   168.319 1.00 126.44 ? 75  ASN B ND2 1 
ATOM 1744 N N   . LEU B 1 76  ? -49.030 6.564   170.770 1.00 131.84 ? 76  LEU B N   1 
ATOM 1745 C CA  . LEU B 1 76  ? -48.927 5.623   171.881 1.00 131.84 ? 76  LEU B CA  1 
ATOM 1746 C C   . LEU B 1 76  ? -48.460 6.258   173.189 1.00 131.84 ? 76  LEU B C   1 
ATOM 1747 O O   . LEU B 1 76  ? -47.501 7.036   173.221 1.00 131.84 ? 76  LEU B O   1 
ATOM 1748 C CB  . LEU B 1 76  ? -47.995 4.478   171.490 1.00 131.84 ? 76  LEU B CB  1 
ATOM 1749 C CG  . LEU B 1 76  ? -48.653 3.327   170.713 1.00 131.84 ? 76  LEU B CG  1 
ATOM 1750 C CD1 . LEU B 1 76  ? -49.123 3.797   169.349 1.00 131.84 ? 76  LEU B CD1 1 
ATOM 1751 C CD2 . LEU B 1 76  ? -47.714 2.134   170.549 1.00 131.84 ? 76  LEU B CD2 1 
ATOM 1752 N N   . GLU B 1 77  ? -49.183 5.926   174.265 1.00 140.60 ? 77  GLU B N   1 
ATOM 1753 C CA  . GLU B 1 77  ? -48.925 6.409   175.620 1.00 140.60 ? 77  GLU B CA  1 
ATOM 1754 C C   . GLU B 1 77  ? -47.731 5.733   176.288 1.00 140.60 ? 77  GLU B C   1 
ATOM 1755 O O   . GLU B 1 77  ? -47.180 6.288   177.245 1.00 140.60 ? 77  GLU B O   1 
ATOM 1756 C CB  . GLU B 1 77  ? -50.174 6.227   176.489 1.00 140.60 ? 77  GLU B CB  1 
ATOM 1757 C CG  . GLU B 1 77  ? -50.534 4.778   176.810 1.00 140.60 ? 77  GLU B CG  1 
ATOM 1758 C CD  . GLU B 1 77  ? -51.356 4.127   175.718 1.00 140.60 ? 77  GLU B CD  1 
ATOM 1759 O OE1 . GLU B 1 77  ? -51.396 4.679   174.597 1.00 140.60 ? 77  GLU B OE1 1 
ATOM 1760 O OE2 . GLU B 1 77  ? -51.963 3.068   175.976 1.00 140.60 ? 77  GLU B OE2 1 
ATOM 1761 N N   . ASP B 1 78  ? -47.321 4.553   175.819 1.00 137.23 ? 78  ASP B N   1 
ATOM 1762 C CA  . ASP B 1 78  ? -46.269 3.774   176.464 1.00 137.23 ? 78  ASP B CA  1 
ATOM 1763 C C   . ASP B 1 78  ? -44.971 3.859   175.674 1.00 137.23 ? 78  ASP B C   1 
ATOM 1764 O O   . ASP B 1 78  ? -44.927 3.448   174.505 1.00 137.23 ? 78  ASP B O   1 
ATOM 1765 C CB  . ASP B 1 78  ? -46.708 2.317   176.607 1.00 137.23 ? 78  ASP B CB  1 
ATOM 1766 C CG  . ASP B 1 78  ? -45.557 1.391   176.943 1.00 137.23 ? 78  ASP B CG  1 
ATOM 1767 O OD1 . ASP B 1 78  ? -44.639 1.817   177.675 1.00 137.23 ? 78  ASP B OD1 1 
ATOM 1768 O OD2 . ASP B 1 78  ? -45.570 0.235   176.472 1.00 137.23 ? 78  ASP B OD2 1 
ATOM 1769 N N   . PRO B 1 79  ? -43.899 4.384   176.277 1.00 134.31 ? 79  PRO B N   1 
ATOM 1770 C CA  . PRO B 1 79  ? -42.610 4.473   175.569 1.00 134.31 ? 79  PRO B CA  1 
ATOM 1771 C C   . PRO B 1 79  ? -41.970 3.149   175.198 1.00 134.31 ? 79  PRO B C   1 
ATOM 1772 O O   . PRO B 1 79  ? -41.272 3.089   174.181 1.00 134.31 ? 79  PRO B O   1 
ATOM 1773 C CB  . PRO B 1 79  ? -41.722 5.231   176.570 1.00 134.31 ? 79  PRO B CB  1 
ATOM 1774 C CG  . PRO B 1 79  ? -42.312 4.919   177.895 1.00 134.31 ? 79  PRO B CG  1 
ATOM 1775 C CD  . PRO B 1 79  ? -43.789 4.890   177.657 1.00 134.31 ? 79  PRO B CD  1 
ATOM 1776 N N   . ALA B 1 80  ? -42.174 2.085   175.973 1.00 131.89 ? 80  ALA B N   1 
ATOM 1777 C CA  . ALA B 1 80  ? -41.616 0.789   175.597 1.00 131.89 ? 80  ALA B CA  1 
ATOM 1778 C C   . ALA B 1 80  ? -42.144 0.291   174.254 1.00 131.89 ? 80  ALA B C   1 
ATOM 1779 O O   . ALA B 1 80  ? -41.364 -0.118  173.384 1.00 131.89 ? 80  ALA B O   1 
ATOM 1780 C CB  . ALA B 1 80  ? -41.917 -0.233  176.693 1.00 131.89 ? 80  ALA B CB  1 
ATOM 1781 N N   . SER B 1 81  ? -43.464 0.283   174.075 1.00 131.36 ? 81  SER B N   1 
ATOM 1782 C CA  . SER B 1 81  ? -44.037 -0.065  172.776 1.00 131.36 ? 81  SER B CA  1 
ATOM 1783 C C   . SER B 1 81  ? -43.517 0.817   171.642 1.00 131.36 ? 81  SER B C   1 
ATOM 1784 O O   . SER B 1 81  ? -43.136 0.311   170.576 1.00 131.36 ? 81  SER B O   1 
ATOM 1785 C CB  . SER B 1 81  ? -45.561 0.017   172.856 1.00 131.36 ? 81  SER B CB  1 
ATOM 1786 O OG  . SER B 1 81  ? -45.984 1.339   173.142 1.00 131.36 ? 81  SER B OG  1 
ATOM 1787 N N   . ARG B 1 82  ? -43.487 2.137   171.848 1.00 132.19 ? 82  ARG B N   1 
ATOM 1788 C CA  . ARG B 1 82  ? -42.917 3.028   170.838 1.00 132.19 ? 82  ARG B CA  1 
ATOM 1789 C C   . ARG B 1 82  ? -41.487 2.651   170.469 1.00 132.19 ? 82  ARG B C   1 
ATOM 1790 O O   . ARG B 1 82  ? -41.144 2.561   169.287 1.00 132.19 ? 82  ARG B O   1 
ATOM 1791 C CB  . ARG B 1 82  ? -42.988 4.493   171.286 1.00 132.19 ? 82  ARG B CB  1 
ATOM 1792 C CG  . ARG B 1 82  ? -44.412 5.019   171.415 1.00 132.19 ? 82  ARG B CG  1 
ATOM 1793 C CD  . ARG B 1 82  ? -44.492 6.478   171.876 1.00 132.19 ? 82  ARG B CD  1 
ATOM 1794 N NE  . ARG B 1 82  ? -43.712 6.819   173.061 1.00 132.19 ? 82  ARG B NE  1 
ATOM 1795 C CZ  . ARG B 1 82  ? -44.225 7.087   174.255 1.00 132.19 ? 82  ARG B CZ  1 
ATOM 1796 N NH1 . ARG B 1 82  ? -45.530 7.054   174.476 1.00 132.19 ? 82  ARG B NH1 1 
ATOM 1797 N NH2 . ARG B 1 82  ? -43.414 7.461   175.239 1.00 132.19 ? 82  ARG B NH2 1 
ATOM 1798 N N   . ASP B 1 83  ? -40.630 2.451   171.469 1.00 130.21 ? 83  ASP B N   1 
ATOM 1799 C CA  . ASP B 1 83  ? -39.235 2.136   171.185 1.00 130.21 ? 83  ASP B CA  1 
ATOM 1800 C C   . ASP B 1 83  ? -39.091 0.800   170.468 1.00 130.21 ? 83  ASP B C   1 
ATOM 1801 O O   . ASP B 1 83  ? -38.318 0.684   169.512 1.00 130.21 ? 83  ASP B O   1 
ATOM 1802 C CB  . ASP B 1 83  ? -38.423 2.139   172.478 1.00 130.21 ? 83  ASP B CB  1 
ATOM 1803 C CG  . ASP B 1 83  ? -38.575 3.428   173.257 1.00 130.21 ? 83  ASP B CG  1 
ATOM 1804 O OD1 . ASP B 1 83  ? -38.562 4.504   172.626 1.00 130.21 ? 83  ASP B OD1 1 
ATOM 1805 O OD2 . ASP B 1 83  ? -38.707 3.370   174.497 1.00 130.21 ? 83  ASP B OD2 1 
ATOM 1806 N N   . LEU B 1 84  ? -39.839 -0.217  170.898 1.00 125.75 ? 84  LEU B N   1 
ATOM 1807 C CA  . LEU B 1 84  ? -39.780 -1.509  170.221 1.00 125.75 ? 84  LEU B CA  1 
ATOM 1808 C C   . LEU B 1 84  ? -40.186 -1.392  168.755 1.00 125.75 ? 84  LEU B C   1 
ATOM 1809 O O   . LEU B 1 84  ? -39.479 -1.881  167.860 1.00 125.75 ? 84  LEU B O   1 
ATOM 1810 C CB  . LEU B 1 84  ? -40.681 -2.514  170.942 1.00 125.75 ? 84  LEU B CB  1 
ATOM 1811 C CG  . LEU B 1 84  ? -40.014 -3.438  171.962 1.00 125.75 ? 84  LEU B CG  1 
ATOM 1812 C CD1 . LEU B 1 84  ? -39.430 -2.642  173.115 1.00 125.75 ? 84  LEU B CD1 1 
ATOM 1813 C CD2 . LEU B 1 84  ? -41.005 -4.472  172.473 1.00 125.75 ? 84  LEU B CD2 1 
ATOM 1814 N N   . VAL B 1 85  ? -41.278 -0.677  168.483 1.00 122.34 ? 85  VAL B N   1 
ATOM 1815 C CA  . VAL B 1 85  ? -41.758 -0.550  167.109 1.00 122.34 ? 85  VAL B CA  1 
ATOM 1816 C C   . VAL B 1 85  ? -40.772 0.249   166.264 1.00 122.34 ? 85  VAL B C   1 
ATOM 1817 O O   . VAL B 1 85  ? -40.425 -0.151  165.144 1.00 122.34 ? 85  VAL B O   1 
ATOM 1818 C CB  . VAL B 1 85  ? -43.160 0.085   167.096 1.00 122.34 ? 85  VAL B CB  1 
ATOM 1819 C CG1 . VAL B 1 85  ? -43.605 0.398   165.673 1.00 122.34 ? 85  VAL B CG1 1 
ATOM 1820 C CG2 . VAL B 1 85  ? -44.162 -0.836  167.768 1.00 122.34 ? 85  VAL B CG2 1 
ATOM 1821 N N   . VAL B 1 86  ? -40.301 1.381   166.784 1.00 118.68 ? 86  VAL B N   1 
ATOM 1822 C CA  . VAL B 1 86  ? -39.402 2.228   166.010 1.00 118.68 ? 86  VAL B CA  1 
ATOM 1823 C C   . VAL B 1 86  ? -38.087 1.509   165.729 1.00 118.68 ? 86  VAL B C   1 
ATOM 1824 O O   . VAL B 1 86  ? -37.567 1.558   164.607 1.00 118.68 ? 86  VAL B O   1 
ATOM 1825 C CB  . VAL B 1 86  ? -39.179 3.559   166.748 1.00 118.68 ? 86  VAL B CB  1 
ATOM 1826 C CG1 . VAL B 1 86  ? -38.131 4.400   166.042 1.00 118.68 ? 86  VAL B CG1 1 
ATOM 1827 C CG2 . VAL B 1 86  ? -40.486 4.329   166.850 1.00 118.68 ? 86  VAL B CG2 1 
ATOM 1828 N N   . SER B 1 87  ? -37.529 0.823   166.729 1.00 118.98 ? 87  SER B N   1 
ATOM 1829 C CA  . SER B 1 87  ? -36.270 0.126   166.503 1.00 118.98 ? 87  SER B CA  1 
ATOM 1830 C C   . SER B 1 87  ? -36.431 -1.005  165.496 1.00 118.98 ? 87  SER B C   1 
ATOM 1831 O O   . SER B 1 87  ? -35.603 -1.153  164.585 1.00 118.98 ? 87  SER B O   1 
ATOM 1832 C CB  . SER B 1 87  ? -35.716 -0.422  167.820 1.00 30.00  ? 87  SER B CB  1 
ATOM 1833 O OG  . SER B 1 87  ? -35.374 0.628   168.706 1.00 30.00  ? 87  SER B OG  1 
ATOM 1834 N N   . TYR B 1 88  ? -37.501 -1.800  165.619 1.00 112.46 ? 88  TYR B N   1 
ATOM 1835 C CA  . TYR B 1 88  ? -37.733 -2.854  164.637 1.00 112.46 ? 88  TYR B CA  1 
ATOM 1836 C C   . TYR B 1 88  ? -37.824 -2.286  163.226 1.00 112.46 ? 88  TYR B C   1 
ATOM 1837 O O   . TYR B 1 88  ? -37.140 -2.755  162.302 1.00 112.46 ? 88  TYR B O   1 
ATOM 1838 C CB  . TYR B 1 88  ? -39.005 -3.627  164.989 1.00 112.46 ? 88  TYR B CB  1 
ATOM 1839 C CG  . TYR B 1 88  ? -39.391 -4.657  163.951 1.00 112.46 ? 88  TYR B CG  1 
ATOM 1840 C CD1 . TYR B 1 88  ? -40.100 -4.293  162.815 1.00 112.46 ? 88  TYR B CD1 1 
ATOM 1841 C CD2 . TYR B 1 88  ? -39.081 -5.997  164.125 1.00 112.46 ? 88  TYR B CD2 1 
ATOM 1842 C CE1 . TYR B 1 88  ? -40.471 -5.229  161.873 1.00 112.46 ? 88  TYR B CE1 1 
ATOM 1843 C CE2 . TYR B 1 88  ? -39.430 -6.939  163.177 1.00 112.46 ? 88  TYR B CE2 1 
ATOM 1844 C CZ  . TYR B 1 88  ? -40.125 -6.548  162.053 1.00 112.46 ? 88  TYR B CZ  1 
ATOM 1845 O OH  . TYR B 1 88  ? -40.498 -7.485  161.118 1.00 112.46 ? 88  TYR B OH  1 
ATOM 1846 N N   . VAL B 1 89  ? -38.653 -1.253  163.046 1.00 111.86 ? 89  VAL B N   1 
ATOM 1847 C CA  . VAL B 1 89  ? -38.878 -0.715  161.708 1.00 111.86 ? 89  VAL B CA  1 
ATOM 1848 C C   . VAL B 1 89  ? -37.573 -0.193  161.127 1.00 111.86 ? 89  VAL B C   1 
ATOM 1849 O O   . VAL B 1 89  ? -37.149 -0.607  160.036 1.00 111.86 ? 89  VAL B O   1 
ATOM 1850 C CB  . VAL B 1 89  ? -39.990 0.357   161.725 1.00 111.86 ? 89  VAL B CB  1 
ATOM 1851 C CG1 . VAL B 1 89  ? -39.600 1.574   162.532 1.00 111.86 ? 89  VAL B CG1 1 
ATOM 1852 C CG2 . VAL B 1 89  ? -40.368 0.774   160.310 1.00 111.86 ? 89  VAL B CG2 1 
ATOM 1853 N N   . ASN B 1 90  ? -36.851 0.613   161.907 1.00 113.71 ? 90  ASN B N   1 
ATOM 1854 C CA  . ASN B 1 90  ? -35.627 1.219   161.407 1.00 113.71 ? 90  ASN B CA  1 
ATOM 1855 C C   . ASN B 1 90  ? -34.608 0.158   161.033 1.00 113.71 ? 90  ASN B C   1 
ATOM 1856 O O   . ASN B 1 90  ? -34.169 0.102   159.884 1.00 113.71 ? 90  ASN B O   1 
ATOM 1857 C CB  . ASN B 1 90  ? -35.042 2.174   162.451 1.00 113.71 ? 90  ASN B CB  1 
ATOM 1858 C CG  . ASN B 1 90  ? -35.882 3.417   162.639 1.00 113.71 ? 90  ASN B CG  1 
ATOM 1859 O OD1 . ASN B 1 90  ? -36.480 3.923   161.691 1.00 113.71 ? 90  ASN B OD1 1 
ATOM 1860 N ND2 . ASN B 1 90  ? -35.930 3.921   163.865 1.00 113.71 ? 90  ASN B ND2 1 
ATOM 1861 N N   . THR B 1 91  ? -34.375 -0.814  161.907 1.00 112.87 ? 91  THR B N   1 
ATOM 1862 C CA  . THR B 1 91  ? -33.292 -1.749  161.637 1.00 112.87 ? 91  THR B CA  1 
ATOM 1863 C C   . THR B 1 91  ? -33.624 -2.688  160.480 1.00 112.87 ? 91  THR B C   1 
ATOM 1864 O O   . THR B 1 91  ? -32.902 -2.707  159.470 1.00 112.87 ? 91  THR B O   1 
ATOM 1865 C CB  . THR B 1 91  ? -32.975 -2.545  162.907 1.00 112.87 ? 91  THR B CB  1 
ATOM 1866 O OG1 . THR B 1 91  ? -32.544 -1.653  163.941 1.00 112.87 ? 91  THR B OG1 1 
ATOM 1867 C CG2 . THR B 1 91  ? -31.884 -3.574  162.667 1.00 112.87 ? 91  THR B CG2 1 
ATOM 1868 N N   . ASN B 1 92  ? -34.782 -3.352  160.513 1.00 109.53 ? 92  ASN B N   1 
ATOM 1869 C CA  . ASN B 1 92  ? -35.034 -4.337  159.464 1.00 109.53 ? 92  ASN B CA  1 
ATOM 1870 C C   . ASN B 1 92  ? -35.334 -3.684  158.117 1.00 109.53 ? 92  ASN B C   1 
ATOM 1871 O O   . ASN B 1 92  ? -34.683 -4.004  157.104 1.00 109.53 ? 92  ASN B O   1 
ATOM 1872 C CB  . ASN B 1 92  ? -36.189 -5.243  159.886 1.00 109.53 ? 92  ASN B CB  1 
ATOM 1873 C CG  . ASN B 1 92  ? -35.859 -6.080  161.104 1.00 109.53 ? 92  ASN B CG  1 
ATOM 1874 O OD1 . ASN B 1 92  ? -36.554 -6.025  162.117 1.00 109.53 ? 92  ASN B OD1 1 
ATOM 1875 N ND2 . ASN B 1 92  ? -34.782 -6.851  161.017 1.00 109.53 ? 92  ASN B ND2 1 
ATOM 1876 N N   . MET B 1 93  ? -36.266 -2.731  158.069 1.00 105.47 ? 93  MET B N   1 
ATOM 1877 C CA  . MET B 1 93  ? -36.573 -2.195  156.751 1.00 105.47 ? 93  MET B CA  1 
ATOM 1878 C C   . MET B 1 93  ? -35.468 -1.277  156.252 1.00 105.47 ? 93  MET B C   1 
ATOM 1879 O O   . MET B 1 93  ? -35.243 -1.211  155.040 1.00 105.47 ? 93  MET B O   1 
ATOM 1880 C CB  . MET B 1 93  ? -37.954 -1.541  156.714 1.00 105.47 ? 93  MET B CB  1 
ATOM 1881 C CG  . MET B 1 93  ? -39.077 -2.590  156.633 1.00 105.47 ? 93  MET B CG  1 
ATOM 1882 S SD  . MET B 1 93  ? -39.457 -3.555  158.101 1.00 105.47 ? 93  MET B SD  1 
ATOM 1883 C CE  . MET B 1 93  ? -40.314 -2.324  159.053 1.00 105.47 ? 93  MET B CE  1 
ATOM 1884 N N   . GLY B 1 94  ? -34.774 -0.548  157.131 1.00 103.30 ? 94  GLY B N   1 
ATOM 1885 C CA  . GLY B 1 94  ? -33.646 0.224   156.665 1.00 103.30 ? 94  GLY B CA  1 
ATOM 1886 C C   . GLY B 1 94  ? -32.572 -0.644  156.038 1.00 103.30 ? 94  GLY B C   1 
ATOM 1887 O O   . GLY B 1 94  ? -32.010 -0.283  155.007 1.00 103.30 ? 94  GLY B O   1 
ATOM 1888 N N   . LEU B 1 95  ? -32.277 -1.809  156.633 1.00 97.96  ? 95  LEU B N   1 
ATOM 1889 C CA  . LEU B 1 95  ? -31.271 -2.664  156.005 1.00 97.96  ? 95  LEU B CA  1 
ATOM 1890 C C   . LEU B 1 95  ? -31.730 -3.196  154.647 1.00 97.96  ? 95  LEU B C   1 
ATOM 1891 O O   . LEU B 1 95  ? -30.960 -3.183  153.671 1.00 97.96  ? 95  LEU B O   1 
ATOM 1892 C CB  . LEU B 1 95  ? -30.931 -3.830  156.934 1.00 97.96  ? 95  LEU B CB  1 
ATOM 1893 C CG  . LEU B 1 95  ? -29.857 -4.803  156.439 1.00 97.96  ? 95  LEU B CG  1 
ATOM 1894 C CD1 . LEU B 1 95  ? -28.531 -4.094  156.216 1.00 97.96  ? 95  LEU B CD1 1 
ATOM 1895 C CD2 . LEU B 1 95  ? -29.694 -5.952  157.416 1.00 97.96  ? 95  LEU B CD2 1 
ATOM 1896 N N   . LYS B 1 96  ? -33.000 -3.600  154.542 1.00 96.82  ? 96  LYS B N   1 
ATOM 1897 C CA  . LYS B 1 96  ? -33.509 -4.076  153.254 1.00 96.82  ? 96  LYS B CA  1 
ATOM 1898 C C   . LYS B 1 96  ? -33.480 -2.988  152.177 1.00 96.82  ? 96  LYS B C   1 
ATOM 1899 O O   . LYS B 1 96  ? -33.004 -3.213  151.050 1.00 96.82  ? 96  LYS B O   1 
ATOM 1900 C CB  . LYS B 1 96  ? -34.922 -4.629  153.431 1.00 96.82  ? 96  LYS B CB  1 
ATOM 1901 C CG  . LYS B 1 96  ? -34.953 -5.998  154.095 1.00 96.82  ? 96  LYS B CG  1 
ATOM 1902 C CD  . LYS B 1 96  ? -36.367 -6.420  154.457 1.00 96.82  ? 96  LYS B CD  1 
ATOM 1903 C CE  . LYS B 1 96  ? -36.434 -7.886  154.866 1.00 96.82  ? 96  LYS B CE  1 
ATOM 1904 N NZ  . LYS B 1 96  ? -36.009 -8.816  153.784 1.00 96.82  ? 96  LYS B NZ  1 
ATOM 1905 N N   . PHE B 1 97  ? -33.942 -1.795  152.561 1.00 93.31  ? 97  PHE B N   1 
ATOM 1906 C CA  . PHE B 1 97  ? -33.992 -0.616  151.666 1.00 93.31  ? 97  PHE B CA  1 
ATOM 1907 C C   . PHE B 1 97  ? -32.576 -0.216  151.270 1.00 93.31  ? 97  PHE B C   1 
ATOM 1908 O O   . PHE B 1 97  ? -32.400 0.222   150.143 1.00 93.31  ? 97  PHE B O   1 
ATOM 1909 C CB  . PHE B 1 97  ? -34.718 0.511   152.402 1.00 30.00  ? 97  PHE B CB  1 
ATOM 1910 C CG  . PHE B 1 97  ? -35.015 1.760   151.611 1.00 30.00  ? 97  PHE B CG  1 
ATOM 1911 C CD1 . PHE B 1 97  ? -35.288 1.710   150.254 1.00 30.00  ? 97  PHE B CD1 1 
ATOM 1912 C CD2 . PHE B 1 97  ? -35.065 2.988   152.247 1.00 30.00  ? 97  PHE B CD2 1 
ATOM 1913 C CE1 . PHE B 1 97  ? -35.577 2.868   149.549 1.00 30.00  ? 97  PHE B CE1 1 
ATOM 1914 C CE2 . PHE B 1 97  ? -35.356 4.144   151.541 1.00 30.00  ? 97  PHE B CE2 1 
ATOM 1915 C CZ  . PHE B 1 97  ? -35.616 4.080   150.194 1.00 30.00  ? 97  PHE B CZ  1 
ATOM 1916 N N   . ARG B 1 98  ? -31.615 -0.300  152.187 1.00 92.70  ? 98  ARG B N   1 
ATOM 1917 C CA  . ARG B 1 98  ? -30.228 0.047   151.907 1.00 92.70  ? 98  ARG B CA  1 
ATOM 1918 C C   . ARG B 1 98  ? -29.642 -0.880  150.853 1.00 92.70  ? 98  ARG B C   1 
ATOM 1919 O O   . ARG B 1 98  ? -29.019 -0.428  149.883 1.00 92.70  ? 98  ARG B O   1 
ATOM 1920 C CB  . ARG B 1 98  ? -29.410 -0.013  153.197 1.00 92.70  ? 98  ARG B CB  1 
ATOM 1921 C CG  . ARG B 1 98  ? -29.626 1.174   154.115 1.00 92.70  ? 98  ARG B CG  1 
ATOM 1922 C CD  . ARG B 1 98  ? -29.154 0.889   155.530 1.00 92.70  ? 98  ARG B CD  1 
ATOM 1923 N NE  . ARG B 1 98  ? -27.704 0.765   155.620 1.00 92.70  ? 98  ARG B NE  1 
ATOM 1924 C CZ  . ARG B 1 98  ? -27.066 0.009   156.504 1.00 92.70  ? 98  ARG B CZ  1 
ATOM 1925 N NH1 . ARG B 1 98  ? -27.717 -0.678  157.428 1.00 92.70  ? 98  ARG B NH1 1 
ATOM 1926 N NH2 . ARG B 1 98  ? -25.739 -0.058  156.461 1.00 92.70  ? 98  ARG B NH2 1 
ATOM 1927 N N   . GLN B 1 99  ? -29.885 -2.185  150.996 1.00 90.50  ? 99  GLN B N   1 
ATOM 1928 C CA  . GLN B 1 99  ? -29.415 -3.131  149.986 1.00 90.50  ? 99  GLN B CA  1 
ATOM 1929 C C   . GLN B 1 99  ? -30.018 -2.844  148.611 1.00 90.50  ? 99  GLN B C   1 
ATOM 1930 O O   . GLN B 1 99  ? -29.298 -2.782  147.602 1.00 90.50  ? 99  GLN B O   1 
ATOM 1931 C CB  . GLN B 1 99  ? -29.742 -4.558  150.428 1.00 90.50  ? 99  GLN B CB  1 
ATOM 1932 C CG  . GLN B 1 99  ? -29.291 -5.640  149.458 1.00 90.50  ? 99  GLN B CG  1 
ATOM 1933 C CD  . GLN B 1 99  ? -29.861 -7.000  149.804 1.00 90.50  ? 99  GLN B CD  1 
ATOM 1934 O OE1 . GLN B 1 99  ? -30.939 -7.371  149.341 1.00 90.50  ? 99  GLN B OE1 1 
ATOM 1935 N NE2 . GLN B 1 99  ? -29.150 -7.743  150.641 1.00 90.50  ? 99  GLN B NE2 1 
ATOM 1936 N N   . LEU B 1 100 ? -31.332 -2.613  148.554 1.00 90.17  ? 100 LEU B N   1 
ATOM 1937 C CA  . LEU B 1 100 ? -31.964 -2.428  147.245 1.00 90.17  ? 100 LEU B CA  1 
ATOM 1938 C C   . LEU B 1 100 ? -31.526 -1.125  146.576 1.00 90.17  ? 100 LEU B C   1 
ATOM 1939 O O   . LEU B 1 100 ? -31.231 -1.101  145.368 1.00 90.17  ? 100 LEU B O   1 
ATOM 1940 C CB  . LEU B 1 100 ? -33.484 -2.480  147.397 1.00 90.17  ? 100 LEU B CB  1 
ATOM 1941 C CG  . LEU B 1 100 ? -34.327 -2.304  146.131 1.00 90.17  ? 100 LEU B CG  1 
ATOM 1942 C CD1 . LEU B 1 100 ? -35.625 -3.075  146.267 1.00 90.17  ? 100 LEU B CD1 1 
ATOM 1943 C CD2 . LEU B 1 100 ? -34.625 -0.837  145.863 1.00 90.17  ? 100 LEU B CD2 1 
ATOM 1944 N N   . LEU B 1 101 ? -31.477 -0.032  147.340 1.00 91.05  ? 101 LEU B N   1 
ATOM 1945 C CA  . LEU B 1 101 ? -30.992 1.233   146.804 1.00 91.05  ? 101 LEU B CA  1 
ATOM 1946 C C   . LEU B 1 101 ? -29.557 1.122   146.316 1.00 91.05  ? 101 LEU B C   1 
ATOM 1947 O O   . LEU B 1 101 ? -29.224 1.637   145.241 1.00 91.05  ? 101 LEU B O   1 
ATOM 1948 C CB  . LEU B 1 101 ? -31.098 2.323   147.871 1.00 91.05  ? 101 LEU B CB  1 
ATOM 1949 C CG  . LEU B 1 101 ? -32.491 2.886   148.159 1.00 91.05  ? 101 LEU B CG  1 
ATOM 1950 C CD1 . LEU B 1 101 ? -32.434 3.826   149.349 1.00 91.05  ? 101 LEU B CD1 1 
ATOM 1951 C CD2 . LEU B 1 101 ? -33.062 3.599   146.944 1.00 91.05  ? 101 LEU B CD2 1 
ATOM 1952 N N   . TRP B 1 102 ? -28.680 0.482   147.096 1.00 86.18  ? 102 TRP B N   1 
ATOM 1953 C CA  . TRP B 1 102 ? -27.304 0.343   146.640 1.00 86.18  ? 102 TRP B CA  1 
ATOM 1954 C C   . TRP B 1 102 ? -27.239 -0.418  145.327 1.00 86.18  ? 102 TRP B C   1 
ATOM 1955 O O   . TRP B 1 102 ? -26.508 -0.027  144.410 1.00 86.18  ? 102 TRP B O   1 
ATOM 1956 C CB  . TRP B 1 102 ? -26.452 -0.368  147.689 1.00 86.18  ? 102 TRP B CB  1 
ATOM 1957 C CG  . TRP B 1 102 ? -25.054 -0.624  147.207 1.00 86.18  ? 102 TRP B CG  1 
ATOM 1958 C CD1 . TRP B 1 102 ? -23.974 0.194   147.361 1.00 86.18  ? 102 TRP B CD1 1 
ATOM 1959 C CD2 . TRP B 1 102 ? -24.591 -1.765  146.473 1.00 86.18  ? 102 TRP B CD2 1 
ATOM 1960 N NE1 . TRP B 1 102 ? -22.865 -0.372  146.783 1.00 86.18  ? 102 TRP B NE1 1 
ATOM 1961 C CE2 . TRP B 1 102 ? -23.219 -1.572  146.223 1.00 86.18  ? 102 TRP B CE2 1 
ATOM 1962 C CE3 . TRP B 1 102 ? -25.208 -2.921  145.985 1.00 86.18  ? 102 TRP B CE3 1 
ATOM 1963 C CZ2 . TRP B 1 102 ? -22.449 -2.499  145.525 1.00 86.18  ? 102 TRP B CZ2 1 
ATOM 1964 C CZ3 . TRP B 1 102 ? -24.436 -3.853  145.318 1.00 86.18  ? 102 TRP B CZ3 1 
ATOM 1965 C CH2 . TRP B 1 102 ? -23.076 -3.626  145.074 1.00 86.18  ? 102 TRP B CH2 1 
ATOM 1966 N N   . PHE B 1 103 ? -28.039 -1.479  145.194 1.00 85.82  ? 103 PHE B N   1 
ATOM 1967 C CA  . PHE B 1 103 ? -28.008 -2.254  143.957 1.00 85.82  ? 103 PHE B CA  1 
ATOM 1968 C C   . PHE B 1 103 ? -28.432 -1.423  142.753 1.00 85.82  ? 103 PHE B C   1 
ATOM 1969 O O   . PHE B 1 103 ? -27.741 -1.401  141.727 1.00 85.82  ? 103 PHE B O   1 
ATOM 1970 C CB  . PHE B 1 103 ? -28.898 -3.488  144.078 1.00 85.82  ? 103 PHE B CB  1 
ATOM 1971 C CG  . PHE B 1 103 ? -28.937 -4.318  142.825 1.00 85.82  ? 103 PHE B CG  1 
ATOM 1972 C CD1 . PHE B 1 103 ? -27.933 -5.228  142.548 1.00 85.82  ? 103 PHE B CD1 1 
ATOM 1973 C CD2 . PHE B 1 103 ? -29.995 -4.208  141.940 1.00 85.82  ? 103 PHE B CD2 1 
ATOM 1974 C CE1 . PHE B 1 103 ? -27.974 -5.996  141.401 1.00 85.82  ? 103 PHE B CE1 1 
ATOM 1975 C CE2 . PHE B 1 103 ? -30.040 -4.976  140.793 1.00 85.82  ? 103 PHE B CE2 1 
ATOM 1976 C CZ  . PHE B 1 103 ? -29.026 -5.864  140.520 1.00 85.82  ? 103 PHE B CZ  1 
ATOM 1977 N N   . HIS B 1 104 ? -29.561 -0.718  142.856 1.00 88.39  ? 104 HIS B N   1 
ATOM 1978 C CA  . HIS B 1 104 ? -30.016 0.058   141.700 1.00 88.39  ? 104 HIS B CA  1 
ATOM 1979 C C   . HIS B 1 104 ? -29.106 1.243   141.379 1.00 88.39  ? 104 HIS B C   1 
ATOM 1980 O O   . HIS B 1 104 ? -28.825 1.508   140.201 1.00 88.39  ? 104 HIS B O   1 
ATOM 1981 C CB  . HIS B 1 104 ? -31.453 0.528   141.915 1.00 88.39  ? 104 HIS B CB  1 
ATOM 1982 C CG  . HIS B 1 104 ? -32.460 -0.575  141.828 1.00 88.39  ? 104 HIS B CG  1 
ATOM 1983 N ND1 . HIS B 1 104 ? -32.666 -1.299  140.675 1.00 88.39  ? 104 HIS B ND1 1 
ATOM 1984 C CD2 . HIS B 1 104 ? -33.334 -1.062  142.740 1.00 88.39  ? 104 HIS B CD2 1 
ATOM 1985 C CE1 . HIS B 1 104 ? -33.620 -2.190  140.881 1.00 88.39  ? 104 HIS B CE1 1 
ATOM 1986 N NE2 . HIS B 1 104 ? -34.037 -2.070  142.128 1.00 88.39  ? 104 HIS B NE2 1 
ATOM 1987 N N   . ILE B 1 105 ? -28.620 1.963   142.392 1.00 90.50  ? 105 ILE B N   1 
ATOM 1988 C CA  . ILE B 1 105 ? -27.694 3.061   142.120 1.00 90.50  ? 105 ILE B CA  1 
ATOM 1989 C C   . ILE B 1 105 ? -26.411 2.553   141.471 1.00 90.50  ? 105 ILE B C   1 
ATOM 1990 O O   . ILE B 1 105 ? -25.892 3.166   140.528 1.00 90.50  ? 105 ILE B O   1 
ATOM 1991 C CB  . ILE B 1 105 ? -27.407 3.846   143.414 1.00 90.50  ? 105 ILE B CB  1 
ATOM 1992 C CG1 . ILE B 1 105 ? -28.631 4.675   143.801 1.00 90.50  ? 105 ILE B CG1 1 
ATOM 1993 C CG2 . ILE B 1 105 ? -26.201 4.758   143.238 1.00 90.50  ? 105 ILE B CG2 1 
ATOM 1994 C CD1 . ILE B 1 105 ? -28.605 5.176   145.222 1.00 90.50  ? 105 ILE B CD1 1 
ATOM 1995 N N   . SER B 1 106 ? -25.882 1.425   141.950 1.00 89.65  ? 106 SER B N   1 
ATOM 1996 C CA  . SER B 1 106 ? -24.676 0.871   141.346 1.00 89.65  ? 106 SER B CA  1 
ATOM 1997 C C   . SER B 1 106 ? -24.912 0.422   139.910 1.00 89.65  ? 106 SER B C   1 
ATOM 1998 O O   . SER B 1 106 ? -24.073 0.665   139.037 1.00 89.65  ? 106 SER B O   1 
ATOM 1999 C CB  . SER B 1 106 ? -24.164 -0.296  142.188 1.00 89.65  ? 106 SER B CB  1 
ATOM 2000 O OG  . SER B 1 106 ? -23.944 0.106   143.528 1.00 89.65  ? 106 SER B OG  1 
ATOM 2001 N N   . CYS B 1 107 ? -26.039 -0.238  139.641 1.00 91.49  ? 107 CYS B N   1 
ATOM 2002 C CA  . CYS B 1 107 ? -26.351 -0.609  138.264 1.00 91.49  ? 107 CYS B CA  1 
ATOM 2003 C C   . CYS B 1 107 ? -26.449 0.606   137.348 1.00 91.49  ? 107 CYS B C   1 
ATOM 2004 O O   . CYS B 1 107 ? -25.940 0.578   136.222 1.00 91.49  ? 107 CYS B O   1 
ATOM 2005 C CB  . CYS B 1 107 ? -27.650 -1.413  138.213 1.00 91.49  ? 107 CYS B CB  1 
ATOM 2006 S SG  . CYS B 1 107 ? -27.532 -3.075  138.909 1.00 91.49  ? 107 CYS B SG  1 
ATOM 2007 N N   . LEU B 1 108 ? -27.090 1.685   137.801 1.00 93.53  ? 108 LEU B N   1 
ATOM 2008 C CA  . LEU B 1 108 ? -27.145 2.881   136.963 1.00 93.53  ? 108 LEU B CA  1 
ATOM 2009 C C   . LEU B 1 108 ? -25.773 3.514   136.742 1.00 93.53  ? 108 LEU B C   1 
ATOM 2010 O O   . LEU B 1 108 ? -25.470 3.962   135.631 1.00 93.53  ? 108 LEU B O   1 
ATOM 2011 C CB  . LEU B 1 108 ? -28.097 3.915   137.565 1.00 93.53  ? 108 LEU B CB  1 
ATOM 2012 C CG  . LEU B 1 108 ? -29.594 3.618   137.499 1.00 93.53  ? 108 LEU B CG  1 
ATOM 2013 C CD1 . LEU B 1 108 ? -30.371 4.642   138.307 1.00 93.53  ? 108 LEU B CD1 1 
ATOM 2014 C CD2 . LEU B 1 108 ? -30.068 3.610   136.058 1.00 93.53  ? 108 LEU B CD2 1 
ATOM 2015 N N   . THR B 1 109 ? -24.933 3.572   137.777 1.00 96.00  ? 109 THR B N   1 
ATOM 2016 C CA  . THR B 1 109 ? -23.636 4.229   137.624 1.00 96.00  ? 109 THR B CA  1 
ATOM 2017 C C   . THR B 1 109 ? -22.631 3.402   136.818 1.00 96.00  ? 109 THR B C   1 
ATOM 2018 O O   . THR B 1 109 ? -22.094 3.869   135.808 1.00 96.00  ? 109 THR B O   1 
ATOM 2019 C CB  . THR B 1 109 ? -23.061 4.557   139.002 1.00 96.00  ? 109 THR B CB  1 
ATOM 2020 O OG1 . THR B 1 109 ? -24.023 5.300   139.759 1.00 96.00  ? 109 THR B OG1 1 
ATOM 2021 C CG2 . THR B 1 109 ? -21.791 5.385   138.868 1.00 96.00  ? 109 THR B CG2 1 
ATOM 2022 N N   . PHE B 1 110 ? -22.364 2.168   137.251 1.00 95.46  ? 110 PHE B N   1 
ATOM 2023 C CA  . PHE B 1 110 ? -21.378 1.318   136.583 1.00 95.46  ? 110 PHE B CA  1 
ATOM 2024 C C   . PHE B 1 110 ? -21.908 0.559   135.369 1.00 95.46  ? 110 PHE B C   1 
ATOM 2025 O O   . PHE B 1 110 ? -21.138 0.303   134.437 1.00 95.46  ? 110 PHE B O   1 
ATOM 2026 C CB  . PHE B 1 110 ? -20.770 0.361   137.604 1.00 95.46  ? 110 PHE B CB  1 
ATOM 2027 C CG  . PHE B 1 110 ? -20.072 1.067   138.731 1.00 95.46  ? 110 PHE B CG  1 
ATOM 2028 C CD1 . PHE B 1 110 ? -18.884 1.743   138.509 1.00 95.46  ? 110 PHE B CD1 1 
ATOM 2029 C CD2 . PHE B 1 110 ? -20.608 1.070   140.005 1.00 95.46  ? 110 PHE B CD2 1 
ATOM 2030 C CE1 . PHE B 1 110 ? -18.239 2.397   139.539 1.00 95.46  ? 110 PHE B CE1 1 
ATOM 2031 C CE2 . PHE B 1 110 ? -19.965 1.721   141.040 1.00 95.46  ? 110 PHE B CE2 1 
ATOM 2032 C CZ  . PHE B 1 110 ? -18.781 2.389   140.804 1.00 95.46  ? 110 PHE B CZ  1 
ATOM 2033 N N   . GLY B 1 111 ? -23.183 0.190   135.340 1.00 95.20  ? 111 GLY B N   1 
ATOM 2034 C CA  . GLY B 1 111 ? -23.646 -0.826  134.408 1.00 95.20  ? 111 GLY B CA  1 
ATOM 2035 C C   . GLY B 1 111 ? -23.747 -2.231  134.970 1.00 95.20  ? 111 GLY B C   1 
ATOM 2036 O O   . GLY B 1 111 ? -22.922 -2.686  135.767 1.00 95.20  ? 111 GLY B O   1 
ATOM 2037 N N   . ARG B 1 112 ? -24.827 -2.910  134.561 1.00 96.63  ? 112 ARG B N   1 
ATOM 2038 C CA  . ARG B 1 112 ? -25.174 -4.235  135.136 1.00 96.63  ? 112 ARG B CA  1 
ATOM 2039 C C   . ARG B 1 112 ? -24.073 -5.272  134.942 1.00 96.63  ? 112 ARG B C   1 
ATOM 2040 O O   . ARG B 1 112 ? -23.605 -5.810  135.958 1.00 96.63  ? 112 ARG B O   1 
ATOM 2041 C CB  . ARG B 1 112 ? -26.485 -4.712  134.506 1.00 96.63  ? 112 ARG B CB  1 
ATOM 2042 C CG  . ARG B 1 112 ? -27.109 -5.920  135.185 1.00 96.63  ? 112 ARG B CG  1 
ATOM 2043 C CD  . ARG B 1 112 ? -28.518 -6.148  134.676 1.00 96.63  ? 112 ARG B CD  1 
ATOM 2044 N NE  . ARG B 1 112 ? -28.559 -6.171  133.223 1.00 96.63  ? 112 ARG B NE  1 
ATOM 2045 C CZ  . ARG B 1 112 ? -28.364 -7.257  132.487 1.00 96.63  ? 112 ARG B CZ  1 
ATOM 2046 N NH1 . ARG B 1 112 ? -28.114 -8.416  133.070 1.00 96.63  ? 112 ARG B NH1 1 
ATOM 2047 N NH2 . ARG B 1 112 ? -28.416 -7.181  131.170 1.00 96.63  ? 112 ARG B NH2 1 
ATOM 2048 N N   . GLU B 1 113 ? -23.706 -5.576  133.702 1.00 100.76 ? 113 GLU B N   1 
ATOM 2049 C CA  . GLU B 1 113 ? -22.712 -6.654  133.492 1.00 100.76 ? 113 GLU B CA  1 
ATOM 2050 C C   . GLU B 1 113 ? -21.542 -6.445  134.461 1.00 100.76 ? 113 GLU B C   1 
ATOM 2051 O O   . GLU B 1 113 ? -21.095 -7.434  135.059 1.00 100.76 ? 113 GLU B O   1 
ATOM 2052 C CB  . GLU B 1 113 ? -22.269 -6.675  132.031 1.00 100.76 ? 113 GLU B CB  1 
ATOM 2053 C CG  . GLU B 1 113 ? -23.391 -7.051  131.084 1.00 100.76 ? 113 GLU B CG  1 
ATOM 2054 C CD  . GLU B 1 113 ? -22.938 -7.618  129.749 1.00 100.76 ? 113 GLU B CD  1 
ATOM 2055 O OE1 . GLU B 1 113 ? -21.716 -7.775  129.559 1.00 100.76 ? 113 GLU B OE1 1 
ATOM 2056 O OE2 . GLU B 1 113 ? -23.812 -7.902  128.904 1.00 100.76 ? 113 GLU B OE2 1 
ATOM 2057 N N   . THR B 1 114 ? -21.089 -5.203  134.629 1.00 93.53  ? 114 THR B N   1 
ATOM 2058 C CA  . THR B 1 114 ? -19.975 -4.909  135.564 1.00 93.53  ? 114 THR B CA  1 
ATOM 2059 C C   . THR B 1 114 ? -20.386 -5.270  136.993 1.00 93.53  ? 114 THR B C   1 
ATOM 2060 O O   . THR B 1 114 ? -19.595 -5.927  137.678 1.00 93.53  ? 114 THR B O   1 
ATOM 2061 C CB  . THR B 1 114 ? -19.552 -3.442  135.471 1.00 93.53  ? 114 THR B CB  1 
ATOM 2062 O OG1 . THR B 1 114 ? -19.200 -3.187  134.112 1.00 93.53  ? 114 THR B OG1 1 
ATOM 2063 C CG2 . THR B 1 114 ? -18.391 -3.101  136.376 1.00 93.53  ? 114 THR B CG2 1 
ATOM 2064 N N   . VAL B 1 115 ? -21.581 -4.861  137.418 1.00 90.86  ? 115 VAL B N   1 
ATOM 2065 C CA  . VAL B 1 115 ? -22.026 -5.111  138.820 1.00 90.86  ? 115 VAL B CA  1 
ATOM 2066 C C   . VAL B 1 115 ? -22.099 -6.617  139.084 1.00 90.86  ? 115 VAL B C   1 
ATOM 2067 O O   . VAL B 1 115 ? -21.737 -7.025  140.192 1.00 90.86  ? 115 VAL B O   1 
ATOM 2068 C CB  . VAL B 1 115 ? -23.371 -4.426  139.115 1.00 90.86  ? 115 VAL B CB  1 
ATOM 2069 C CG1 . VAL B 1 115 ? -23.888 -4.778  140.500 1.00 90.86  ? 115 VAL B CG1 1 
ATOM 2070 C CG2 . VAL B 1 115 ? -23.280 -2.918  138.951 1.00 90.86  ? 115 VAL B CG2 1 
ATOM 2071 N N   . ILE B 1 116 ? -22.575 -7.396  138.111 1.00 91.98  ? 116 ILE B N   1 
ATOM 2072 C CA  . ILE B 1 116 ? -22.660 -8.877  138.276 1.00 91.98  ? 116 ILE B CA  1 
ATOM 2073 C C   . ILE B 1 116 ? -21.256 -9.408  138.577 1.00 91.98  ? 116 ILE B C   1 
ATOM 2074 O O   . ILE B 1 116 ? -21.086 -10.101 139.610 1.00 91.98  ? 116 ILE B O   1 
ATOM 2075 C CB  . ILE B 1 116 ? -23.255 -9.521  137.009 1.00 30.00  ? 116 ILE B CB  1 
ATOM 2076 C CG1 . ILE B 1 116 ? -24.501 -8.773  136.527 1.00 30.00  ? 116 ILE B CG1 1 
ATOM 2077 C CG2 . ILE B 1 116 ? -23.533 -11.000 137.235 1.00 30.00  ? 116 ILE B CG2 1 
ATOM 2078 C CD1 . ILE B 1 116 ? -25.036 -9.258  135.201 1.00 30.00  ? 116 ILE B CD1 1 
ATOM 2079 N N   . GLU B 1 117 ? -20.285 -9.070  137.723 1.00 94.67  ? 117 GLU B N   1 
ATOM 2080 C CA  . GLU B 1 117 ? -18.897 -9.573  137.895 1.00 94.67  ? 117 GLU B CA  1 
ATOM 2081 C C   . GLU B 1 117 ? -18.376 -9.187  139.281 1.00 94.67  ? 117 GLU B C   1 
ATOM 2082 O O   . GLU B 1 117 ? -17.847 -10.075 139.973 1.00 94.67  ? 117 GLU B O   1 
ATOM 2083 C CB  . GLU B 1 117 ? -17.998 -8.978  136.810 1.00 94.67  ? 117 GLU B CB  1 
ATOM 2084 C CG  . GLU B 1 117 ? -18.575 -9.112  135.413 1.00 94.67  ? 117 GLU B CG  1 
ATOM 2085 C CD  . GLU B 1 117 ? -18.271 -7.944  134.490 1.00 94.67  ? 117 GLU B CD  1 
ATOM 2086 O OE1 . GLU B 1 117 ? -17.563 -7.016  134.928 1.00 94.67  ? 117 GLU B OE1 1 
ATOM 2087 O OE2 . GLU B 1 117 ? -18.752 -7.960  133.340 1.00 94.67  ? 117 GLU B OE2 1 
ATOM 2088 N N   . TYR B 1 118 ? -18.531 -7.918  139.669 1.00 88.47  ? 118 TYR B N   1 
ATOM 2089 C CA  . TYR B 1 118 ? -17.984 -7.448  140.969 1.00 88.47  ? 118 TYR B CA  1 
ATOM 2090 C C   . TYR B 1 118 ? -18.637 -8.227  142.116 1.00 88.47  ? 118 TYR B C   1 
ATOM 2091 O O   . TYR B 1 118 ? -17.915 -8.657  143.037 1.00 88.47  ? 118 TYR B O   1 
ATOM 2092 C CB  . TYR B 1 118 ? -18.190 -5.940  141.132 1.00 88.47  ? 118 TYR B CB  1 
ATOM 2093 C CG  . TYR B 1 118 ? -17.612 -5.371  142.402 1.00 88.47  ? 118 TYR B CG  1 
ATOM 2094 C CD1 . TYR B 1 118 ? -16.245 -5.220  142.559 1.00 88.47  ? 118 TYR B CD1 1 
ATOM 2095 C CD2 . TYR B 1 118 ? -18.430 -4.985  143.451 1.00 88.47  ? 118 TYR B CD2 1 
ATOM 2096 C CE1 . TYR B 1 118 ? -15.703 -4.702  143.723 1.00 88.47  ? 118 TYR B CE1 1 
ATOM 2097 C CE2 . TYR B 1 118 ? -17.905 -4.464  144.622 1.00 88.47  ? 118 TYR B CE2 1 
ATOM 2098 C CZ  . TYR B 1 118 ? -16.537 -4.321  144.759 1.00 88.47  ? 118 TYR B CZ  1 
ATOM 2099 O OH  . TYR B 1 118 ? -16.013 -3.806  145.909 1.00 88.47  ? 118 TYR B OH  1 
ATOM 2100 N N   . LEU B 1 119 ? -19.961 -8.405  142.053 1.00 87.96  ? 119 LEU B N   1 
ATOM 2101 C CA  . LEU B 1 119 ? -20.686 -9.152  143.115 1.00 87.96  ? 119 LEU B CA  1 
ATOM 2102 C C   . LEU B 1 119 ? -20.117 -10.572 143.202 1.00 87.96  ? 119 LEU B C   1 
ATOM 2103 O O   . LEU B 1 119 ? -19.821 -11.021 144.327 1.00 87.96  ? 119 LEU B O   1 
ATOM 2104 C CB  . LEU B 1 119 ? -22.180 -9.180  142.778 1.00 87.96  ? 119 LEU B CB  1 
ATOM 2105 C CG  . LEU B 1 119 ? -22.896 -7.833  142.875 1.00 87.96  ? 119 LEU B CG  1 
ATOM 2106 C CD1 . LEU B 1 119 ? -24.354 -7.965  142.461 1.00 87.96  ? 119 LEU B CD1 1 
ATOM 2107 C CD2 . LEU B 1 119 ? -22.790 -7.262  144.280 1.00 87.96  ? 119 LEU B CD2 1 
ATOM 2108 N N   . VAL B 1 120 ? -19.953 -11.236 142.055 1.00 86.59  ? 120 VAL B N   1 
ATOM 2109 C CA  . VAL B 1 120 ? -19.425 -12.634 142.044 1.00 86.59  ? 120 VAL B CA  1 
ATOM 2110 C C   . VAL B 1 120 ? -18.036 -12.633 142.693 1.00 86.59  ? 120 VAL B C   1 
ATOM 2111 O O   . VAL B 1 120 ? -17.777 -13.513 143.540 1.00 86.59  ? 120 VAL B O   1 
ATOM 2112 C CB  . VAL B 1 120 ? -19.375 -13.203 140.614 1.00 86.59  ? 120 VAL B CB  1 
ATOM 2113 C CG1 . VAL B 1 120 ? -18.708 -14.569 140.574 1.00 86.59  ? 120 VAL B CG1 1 
ATOM 2114 C CG2 . VAL B 1 120 ? -20.757 -13.260 139.984 1.00 86.59  ? 120 VAL B CG2 1 
ATOM 2115 N N   . SER B 1 121 ? -17.190 -11.670 142.321 1.00 89.18  ? 121 SER B N   1 
ATOM 2116 C CA  . SER B 1 121 ? -15.811 -11.596 142.871 1.00 89.18  ? 121 SER B CA  1 
ATOM 2117 C C   . SER B 1 121 ? -15.875 -11.466 144.394 1.00 89.18  ? 121 SER B C   1 
ATOM 2118 O O   . SER B 1 121 ? -15.150 -12.211 145.079 1.00 89.18  ? 121 SER B O   1 
ATOM 2119 C CB  . SER B 1 121 ? -15.054 -10.448 142.258 1.00 89.18  ? 121 SER B CB  1 
ATOM 2120 O OG  . SER B 1 121 ? -15.093 -10.519 140.840 1.00 89.18  ? 121 SER B OG  1 
ATOM 2121 N N   . PHE B 1 122 ? -16.725 -10.566 144.895 1.00 88.14  ? 122 PHE B N   1 
ATOM 2122 C CA  . PHE B 1 122 ? -16.851 -10.361 146.361 1.00 88.14  ? 122 PHE B CA  1 
ATOM 2123 C C   . PHE B 1 122 ? -17.284 -11.675 147.014 1.00 88.14  ? 122 PHE B C   1 
ATOM 2124 O O   . PHE B 1 122 ? -16.671 -12.071 148.021 1.00 88.14  ? 122 PHE B O   1 
ATOM 2125 C CB  . PHE B 1 122 ? -17.854 -9.247  146.669 1.00 88.14  ? 122 PHE B CB  1 
ATOM 2126 C CG  . PHE B 1 122 ? -18.003 -8.934  148.137 1.00 88.14  ? 122 PHE B CG  1 
ATOM 2127 C CD1 . PHE B 1 122 ? -18.750 -9.754  148.968 1.00 88.14  ? 122 PHE B CD1 1 
ATOM 2128 C CD2 . PHE B 1 122 ? -17.392 -7.820  148.689 1.00 88.14  ? 122 PHE B CD2 1 
ATOM 2129 C CE1 . PHE B 1 122 ? -18.882 -9.467  150.317 1.00 88.14  ? 122 PHE B CE1 1 
ATOM 2130 C CE2 . PHE B 1 122 ? -17.526 -7.533  150.038 1.00 88.14  ? 122 PHE B CE2 1 
ATOM 2131 C CZ  . PHE B 1 122 ? -18.271 -8.356  150.849 1.00 88.14  ? 122 PHE B CZ  1 
ATOM 2132 N N   . GLY B 1 123 ? -18.300 -12.332 146.446 1.00 88.07  ? 123 GLY B N   1 
ATOM 2133 C CA  . GLY B 1 123 ? -18.796 -13.601 147.014 1.00 88.07  ? 123 GLY B CA  1 
ATOM 2134 C C   . GLY B 1 123 ? -17.694 -14.642 147.082 1.00 88.07  ? 123 GLY B C   1 
ATOM 2135 O O   . GLY B 1 123 ? -17.629 -15.367 148.095 1.00 88.07  ? 123 GLY B O   1 
ATOM 2136 N N   . VAL B 1 124 ? -16.859 -14.715 146.043 1.00 85.98  ? 124 VAL B N   1 
ATOM 2137 C CA  . VAL B 1 124 ? -15.739 -15.704 146.015 1.00 85.98  ? 124 VAL B CA  1 
ATOM 2138 C C   . VAL B 1 124 ? -14.711 -15.337 147.091 1.00 85.98  ? 124 VAL B C   1 
ATOM 2139 O O   . VAL B 1 124 ? -14.289 -16.246 147.829 1.00 85.98  ? 124 VAL B O   1 
ATOM 2140 C CB  . VAL B 1 124 ? -15.089 -15.769 144.620 1.00 85.98  ? 124 VAL B CB  1 
ATOM 2141 C CG1 . VAL B 1 124 ? -13.878 -16.690 144.605 1.00 85.98  ? 124 VAL B CG1 1 
ATOM 2142 C CG2 . VAL B 1 124 ? -16.089 -16.180 143.551 1.00 85.98  ? 124 VAL B CG2 1 
ATOM 2143 N N   . TRP B 1 125 ? -14.333 -14.059 147.183 1.00 88.79  ? 125 TRP B N   1 
ATOM 2144 C CA  . TRP B 1 125 ? -13.287 -13.621 148.148 1.00 88.79  ? 125 TRP B CA  1 
ATOM 2145 C C   . TRP B 1 125 ? -13.779 -13.805 149.587 1.00 88.79  ? 125 TRP B C   1 
ATOM 2146 O O   . TRP B 1 125 ? -12.993 -14.304 150.419 1.00 88.79  ? 125 TRP B O   1 
ATOM 2147 C CB  . TRP B 1 125 ? -12.899 -12.165 147.863 1.00 88.79  ? 125 TRP B CB  1 
ATOM 2148 C CG  . TRP B 1 125 ? -11.911 -11.579 148.824 1.00 88.79  ? 125 TRP B CG  1 
ATOM 2149 C CD1 . TRP B 1 125 ? -10.551 -11.683 148.775 1.00 88.79  ? 125 TRP B CD1 1 
ATOM 2150 C CD2 . TRP B 1 125 ? -12.209 -10.771 149.977 1.00 88.79  ? 125 TRP B CD2 1 
ATOM 2151 N NE1 . TRP B 1 125 ? -9.984  -11.005 149.819 1.00 88.79  ? 125 TRP B NE1 1 
ATOM 2152 C CE2 . TRP B 1 125 ? -10.975 -10.434 150.574 1.00 88.79  ? 125 TRP B CE2 1 
ATOM 2153 C CE3 . TRP B 1 125 ? -13.391 -10.306 150.563 1.00 88.79  ? 125 TRP B CE3 1 
ATOM 2154 C CZ2 . TRP B 1 125 ? -10.895 -9.654  151.726 1.00 88.79  ? 125 TRP B CZ2 1 
ATOM 2155 C CZ3 . TRP B 1 125 ? -13.310 -9.536  151.702 1.00 88.79  ? 125 TRP B CZ3 1 
ATOM 2156 C CH2 . TRP B 1 125 ? -12.079 -9.217  152.274 1.00 88.79  ? 125 TRP B CH2 1 
ATOM 2157 N N   . ILE B 1 126 ? -15.036 -13.464 149.865 1.00 89.52  ? 126 ILE B N   1 
ATOM 2158 C CA  . ILE B 1 126 ? -15.565 -13.520 151.260 1.00 89.52  ? 126 ILE B CA  1 
ATOM 2159 C C   . ILE B 1 126 ? -15.681 -14.972 151.714 1.00 89.52  ? 126 ILE B C   1 
ATOM 2160 O O   . ILE B 1 126 ? -15.560 -15.204 152.927 1.00 89.52  ? 126 ILE B O   1 
ATOM 2161 C CB  . ILE B 1 126 ? -16.921 -12.798 151.374 1.00 89.52  ? 126 ILE B CB  1 
ATOM 2162 C CG1 . ILE B 1 126 ? -17.307 -12.542 152.831 1.00 89.52  ? 126 ILE B CG1 1 
ATOM 2163 C CG2 . ILE B 1 126 ? -18.006 -13.561 150.631 1.00 89.52  ? 126 ILE B CG2 1 
ATOM 2164 C CD1 . ILE B 1 126 ? -16.326 -11.670 153.574 1.00 89.52  ? 126 ILE B CD1 1 
ATOM 2165 N N   . ARG B 1 127 ? -15.932 -15.912 150.804 1.00 90.30  ? 127 ARG B N   1 
ATOM 2166 C CA  . ARG B 1 127 ? -16.060 -17.295 151.336 1.00 90.30  ? 127 ARG B CA  1 
ATOM 2167 C C   . ARG B 1 127 ? -14.675 -17.854 151.699 1.00 90.30  ? 127 ARG B C   1 
ATOM 2168 O O   . ARG B 1 127 ? -14.643 -18.870 152.406 1.00 90.30  ? 127 ARG B O   1 
ATOM 2169 C CB  . ARG B 1 127 ? -16.792 -18.209 150.347 1.00 90.30  ? 127 ARG B CB  1 
ATOM 2170 C CG  . ARG B 1 127 ? -18.230 -17.803 150.063 1.00 90.30  ? 127 ARG B CG  1 
ATOM 2171 C CD  . ARG B 1 127 ? -18.939 -18.823 149.196 1.00 90.30  ? 127 ARG B CD  1 
ATOM 2172 N NE  . ARG B 1 127 ? -18.271 -19.022 147.920 1.00 90.30  ? 127 ARG B NE  1 
ATOM 2173 C CZ  . ARG B 1 127 ? -18.534 -18.329 146.821 1.00 90.30  ? 127 ARG B CZ  1 
ATOM 2174 N NH1 . ARG B 1 127 ? -19.459 -17.385 146.841 1.00 90.30  ? 127 ARG B NH1 1 
ATOM 2175 N NH2 . ARG B 1 127 ? -17.875 -18.581 145.706 1.00 90.30  ? 127 ARG B NH2 1 
ATOM 2176 N N   . THR B 1 128 ? -13.579 -17.212 151.275 1.00 93.86  ? 128 THR B N   1 
ATOM 2177 C CA  . THR B 1 128 ? -12.265 -17.726 151.680 1.00 93.86  ? 128 THR B CA  1 
ATOM 2178 C C   . THR B 1 128 ? -12.006 -17.507 153.173 1.00 93.86  ? 128 THR B C   1 
ATOM 2179 O O   . THR B 1 128 ? -12.222 -16.400 153.681 1.00 93.86  ? 128 THR B O   1 
ATOM 2180 C CB  . THR B 1 128 ? -11.163 -17.056 150.866 1.00 93.86  ? 128 THR B CB  1 
ATOM 2181 O OG1 . THR B 1 128 ? -11.373 -17.313 149.473 1.00 93.86  ? 128 THR B OG1 1 
ATOM 2182 C CG2 . THR B 1 128 ? -9.797  -17.593 151.273 1.00 93.86  ? 128 THR B CG2 1 
ATOM 2183 N N   . PRO B 1 129 ? -11.553 -18.530 153.901 1.00 93.67  ? 129 PRO B N   1 
ATOM 2184 C CA  . PRO B 1 129 ? -11.236 -18.376 155.336 1.00 93.67  ? 129 PRO B CA  1 
ATOM 2185 C C   . PRO B 1 129 ? -10.160 -17.332 155.595 1.00 93.67  ? 129 PRO B C   1 
ATOM 2186 O O   . PRO B 1 129 ? -9.209  -17.198 154.810 1.00 93.67  ? 129 PRO B O   1 
ATOM 2187 C CB  . PRO B 1 129 ? -10.753 -19.777 155.745 1.00 93.67  ? 129 PRO B CB  1 
ATOM 2188 C CG  . PRO B 1 129 ? -11.389 -20.690 154.781 1.00 93.67  ? 129 PRO B CG  1 
ATOM 2189 C CD  . PRO B 1 129 ? -11.446 -19.936 153.481 1.00 93.67  ? 129 PRO B CD  1 
ATOM 2190 N N   . PRO B 1 130 ? -10.277 -16.574 156.693 1.00 95.48  ? 130 PRO B N   1 
ATOM 2191 C CA  . PRO B 1 130 ? -9.400  -15.405 156.891 1.00 95.48  ? 130 PRO B CA  1 
ATOM 2192 C C   . PRO B 1 130 ? -7.907  -15.710 156.929 1.00 95.48  ? 130 PRO B C   1 
ATOM 2193 O O   . PRO B 1 130 ? -7.108  -14.841 156.558 1.00 95.48  ? 130 PRO B O   1 
ATOM 2194 C CB  . PRO B 1 130 ? -9.870  -14.850 158.244 1.00 95.48  ? 130 PRO B CB  1 
ATOM 2195 C CG  . PRO B 1 130 ? -11.269 -15.284 158.361 1.00 95.48  ? 130 PRO B CG  1 
ATOM 2196 C CD  . PRO B 1 130 ? -11.293 -16.659 157.756 1.00 95.48  ? 130 PRO B CD  1 
ATOM 2197 N N   . ALA B 1 131 ? -7.499  -16.907 157.361 1.00 92.98  ? 131 ALA B N   1 
ATOM 2198 C CA  . ALA B 1 131 ? -6.076  -17.231 157.405 1.00 92.98  ? 131 ALA B CA  1 
ATOM 2199 C C   . ALA B 1 131 ? -5.433  -17.235 156.027 1.00 92.98  ? 131 ALA B C   1 
ATOM 2200 O O   . ALA B 1 131 ? -4.216  -17.043 155.922 1.00 92.98  ? 131 ALA B O   1 
ATOM 2201 C CB  . ALA B 1 131 ? -5.868  -18.592 158.070 1.00 92.98  ? 131 ALA B CB  1 
ATOM 2202 N N   . TYR B 1 132 ? -6.215  -17.447 154.975 1.00 93.11  ? 132 TYR B N   1 
ATOM 2203 C CA  . TYR B 1 132 ? -5.717  -17.523 153.612 1.00 93.11  ? 132 TYR B CA  1 
ATOM 2204 C C   . TYR B 1 132 ? -6.196  -16.356 152.765 1.00 93.11  ? 132 TYR B C   1 
ATOM 2205 O O   . TYR B 1 132 ? -5.730  -16.192 151.633 1.00 93.11  ? 132 TYR B O   1 
ATOM 2206 C CB  . TYR B 1 132 ? -6.129  -18.852 152.966 1.00 93.11  ? 132 TYR B CB  1 
ATOM 2207 C CG  . TYR B 1 132 ? -5.952  -20.036 153.890 1.00 93.11  ? 132 TYR B CG  1 
ATOM 2208 C CD1 . TYR B 1 132 ? -4.688  -20.424 154.311 1.00 93.11  ? 132 TYR B CD1 1 
ATOM 2209 C CD2 . TYR B 1 132 ? -7.043  -20.756 154.350 1.00 93.11  ? 132 TYR B CD2 1 
ATOM 2210 C CE1 . TYR B 1 132 ? -4.513  -21.506 155.148 1.00 93.11  ? 132 TYR B CE1 1 
ATOM 2211 C CE2 . TYR B 1 132 ? -6.877  -21.851 155.176 1.00 93.11  ? 132 TYR B CE2 1 
ATOM 2212 C CZ  . TYR B 1 132 ? -5.610  -22.218 155.575 1.00 93.11  ? 132 TYR B CZ  1 
ATOM 2213 O OH  . TYR B 1 132 ? -5.444  -23.276 156.436 1.00 93.11  ? 132 TYR B OH  1 
ATOM 2214 N N   . ARG B 1 133 ? -7.109  -15.554 153.291 1.00 93.64  ? 133 ARG B N   1 
ATOM 2215 C CA  . ARG B 1 133 ? -7.673  -14.431 152.559 1.00 93.64  ? 133 ARG B CA  1 
ATOM 2216 C C   . ARG B 1 133 ? -6.637  -13.314 152.447 1.00 93.64  ? 133 ARG B C   1 
ATOM 2217 O O   . ARG B 1 133 ? -6.050  -12.920 153.461 1.00 93.64  ? 133 ARG B O   1 
ATOM 2218 C CB  . ARG B 1 133 ? -8.912  -13.948 153.303 1.00 93.64  ? 133 ARG B CB  1 
ATOM 2219 C CG  . ARG B 1 133 ? -9.799  -12.976 152.572 1.00 93.64  ? 133 ARG B CG  1 
ATOM 2220 C CD  . ARG B 1 133 ? -10.846 -12.440 153.531 1.00 93.64  ? 133 ARG B CD  1 
ATOM 2221 N NE  . ARG B 1 133 ? -11.719 -13.494 154.033 1.00 93.64  ? 133 ARG B NE  1 
ATOM 2222 C CZ  . ARG B 1 133 ? -12.598 -13.332 155.012 1.00 93.64  ? 133 ARG B CZ  1 
ATOM 2223 N NH1 . ARG B 1 133 ? -12.720 -12.180 155.650 1.00 93.64  ? 133 ARG B NH1 1 
ATOM 2224 N NH2 . ARG B 1 133 ? -13.371 -14.356 155.363 1.00 93.64  ? 133 ARG B NH2 1 
ATOM 2225 N N   . PRO B 1 134 ? -6.384  -12.779 151.249 1.00 92.54  ? 134 PRO B N   1 
ATOM 2226 C CA  . PRO B 1 134 ? -5.552  -11.580 151.150 1.00 92.54  ? 134 PRO B CA  1 
ATOM 2227 C C   . PRO B 1 134 ? -6.231  -10.381 151.787 1.00 92.54  ? 134 PRO B C   1 
ATOM 2228 O O   . PRO B 1 134 ? -7.468  -10.265 151.769 1.00 92.54  ? 134 PRO B O   1 
ATOM 2229 C CB  . PRO B 1 134 ? -5.381  -11.393 149.633 1.00 92.54  ? 134 PRO B CB  1 
ATOM 2230 C CG  . PRO B 1 134 ? -6.599  -11.988 149.054 1.00 92.54  ? 134 PRO B CG  1 
ATOM 2231 C CD  . PRO B 1 134 ? -6.940  -13.161 149.938 1.00 92.54  ? 134 PRO B CD  1 
ATOM 2232 N N   . PRO B 1 135 ? -5.456  -9.456  152.364 1.00 95.40  ? 135 PRO B N   1 
ATOM 2233 C CA  . PRO B 1 135 ? -6.012  -8.566  153.396 1.00 95.40  ? 135 PRO B CA  1 
ATOM 2234 C C   . PRO B 1 135 ? -6.968  -7.508  152.872 1.00 95.40  ? 135 PRO B C   1 
ATOM 2235 O O   . PRO B 1 135 ? -7.776  -7.001  153.660 1.00 95.40  ? 135 PRO B O   1 
ATOM 2236 C CB  . PRO B 1 135 ? -4.762  -7.916  154.006 1.00 95.40  ? 135 PRO B CB  1 
ATOM 2237 C CG  . PRO B 1 135 ? -3.748  -7.984  152.919 1.00 95.40  ? 135 PRO B CG  1 
ATOM 2238 C CD  . PRO B 1 135 ? -4.000  -9.294  152.239 1.00 95.40  ? 135 PRO B CD  1 
ATOM 2239 N N   . ASN B 1 136 ? -6.917  -7.152  151.591 1.00 97.42  ? 136 ASN B N   1 
ATOM 2240 C CA  . ASN B 1 136 ? -7.747  -6.085  151.049 1.00 97.42  ? 136 ASN B CA  1 
ATOM 2241 C C   . ASN B 1 136 ? -8.777  -6.650  150.082 1.00 97.42  ? 136 ASN B C   1 
ATOM 2242 O O   . ASN B 1 136 ? -8.434  -7.412  149.172 1.00 97.42  ? 136 ASN B O   1 
ATOM 2243 C CB  . ASN B 1 136 ? -6.889  -5.039  150.337 1.00 97.42  ? 136 ASN B CB  1 
ATOM 2244 C CG  . ASN B 1 136 ? -5.874  -4.395  151.256 1.00 97.42  ? 136 ASN B CG  1 
ATOM 2245 O OD1 . ASN B 1 136 ? -6.188  -4.037  152.391 1.00 97.42  ? 136 ASN B OD1 1 
ATOM 2246 N ND2 . ASN B 1 136 ? -4.650  -4.240  150.769 1.00 97.42  ? 136 ASN B ND2 1 
ATOM 2247 N N   . ALA B 1 137 ? -10.035 -6.268  150.289 1.00 90.63  ? 137 ALA B N   1 
ATOM 2248 C CA  . ALA B 1 137 ? -11.133 -6.740  149.467 1.00 90.63  ? 137 ALA B CA  1 
ATOM 2249 C C   . ALA B 1 137 ? -11.076 -6.134  148.066 1.00 90.63  ? 137 ALA B C   1 
ATOM 2250 O O   . ALA B 1 137 ? -10.433 -5.106  147.846 1.00 90.63  ? 137 ALA B O   1 
ATOM 2251 C CB  . ALA B 1 137 ? -12.466 -6.404  150.126 1.00 90.63  ? 137 ALA B CB  1 
ATOM 2252 N N   . PRO B 1 138 ? -11.749 -6.757  147.099 1.00 91.06  ? 138 PRO B N   1 
ATOM 2253 C CA  . PRO B 1 138 ? -11.935 -6.109  145.797 1.00 91.06  ? 138 PRO B CA  1 
ATOM 2254 C C   . PRO B 1 138 ? -12.738 -4.826  145.939 1.00 91.06  ? 138 PRO B C   1 
ATOM 2255 O O   . PRO B 1 138 ? -13.728 -4.770  146.673 1.00 91.06  ? 138 PRO B O   1 
ATOM 2256 C CB  . PRO B 1 138 ? -12.693 -7.162  144.979 1.00 91.06  ? 138 PRO B CB  1 
ATOM 2257 C CG  . PRO B 1 138 ? -12.370 -8.452  145.641 1.00 91.06  ? 138 PRO B CG  1 
ATOM 2258 C CD  . PRO B 1 138 ? -12.326 -8.109  147.102 1.00 91.06  ? 138 PRO B CD  1 
ATOM 2259 N N   . ILE B 1 139 ? -12.305 -3.787  145.230 1.00 93.59  ? 139 ILE B N   1 
ATOM 2260 C CA  . ILE B 1 139 ? -12.940 -2.477  145.286 1.00 93.59  ? 139 ILE B CA  1 
ATOM 2261 C C   . ILE B 1 139 ? -13.585 -2.174  143.943 1.00 93.59  ? 139 ILE B C   1 
ATOM 2262 O O   . ILE B 1 139 ? -13.017 -2.462  142.884 1.00 93.59  ? 139 ILE B O   1 
ATOM 2263 C CB  . ILE B 1 139 ? -11.918 -1.381  145.650 1.00 93.59  ? 139 ILE B CB  1 
ATOM 2264 C CG1 . ILE B 1 139 ? -11.376 -1.598  147.064 1.00 93.59  ? 139 ILE B CG1 1 
ATOM 2265 C CG2 . ILE B 1 139 ? -12.535 0.002   145.500 1.00 93.59  ? 139 ILE B CG2 1 
ATOM 2266 C CD1 . ILE B 1 139 ? -12.430 -1.541  148.144 1.00 93.59  ? 139 ILE B CD1 1 
ATOM 2267 N N   . LEU B 1 140 ? -14.776 -1.590  143.998 1.00 94.40  ? 140 LEU B N   1 
ATOM 2268 C CA  . LEU B 1 140 ? -15.461 -1.029  142.842 1.00 94.40  ? 140 LEU B CA  1 
ATOM 2269 C C   . LEU B 1 140 ? -15.489 0.486   142.989 1.00 94.40  ? 140 LEU B C   1 
ATOM 2270 O O   . LEU B 1 140 ? -16.127 1.005   143.911 1.00 94.40  ? 140 LEU B O   1 
ATOM 2271 C CB  . LEU B 1 140 ? -16.876 -1.594  142.738 1.00 94.40  ? 140 LEU B CB  1 
ATOM 2272 C CG  . LEU B 1 140 ? -17.741 -1.101  141.582 1.00 94.40  ? 140 LEU B CG  1 
ATOM 2273 C CD1 . LEU B 1 140 ? -17.198 -1.602  140.258 1.00 94.40  ? 140 LEU B CD1 1 
ATOM 2274 C CD2 . LEU B 1 140 ? -19.173 -1.559  141.790 1.00 94.40  ? 140 LEU B CD2 1 
ATOM 2275 N N   . SER B 1 141 ? -14.813 1.193   142.087 1.00 103.52 ? 141 SER B N   1 
ATOM 2276 C CA  . SER B 1 141 ? -14.628 2.626   142.264 1.00 103.52 ? 141 SER B CA  1 
ATOM 2277 C C   . SER B 1 141 ? -14.586 3.312   140.908 1.00 103.52 ? 141 SER B C   1 
ATOM 2278 O O   . SER B 1 141 ? -14.099 2.754   139.921 1.00 103.52 ? 141 SER B O   1 
ATOM 2279 C CB  . SER B 1 141 ? -13.348 2.934   143.047 1.00 103.52 ? 141 SER B CB  1 
ATOM 2280 O OG  . SER B 1 141 ? -13.111 4.329   143.102 1.00 103.52 ? 141 SER B OG  1 
ATOM 2281 N N   . THR B 1 142 ? -14.994 4.586   140.890 1.00 109.10 ? 142 THR B N   1 
ATOM 2282 C CA  . THR B 1 142 ? -15.033 5.411   139.653 1.00 109.10 ? 142 THR B CA  1 
ATOM 2283 C C   . THR B 1 142 ? -13.775 6.276   139.564 1.00 109.10 ? 142 THR B C   1 
ATOM 2284 O O   . THR B 1 142 ? -13.559 6.866   138.492 1.00 109.10 ? 142 THR B O   1 
ATOM 2285 C CB  . THR B 1 142 ? -16.292 6.285   139.625 1.00 109.10 ? 142 THR B CB  1 
ATOM 2286 O OG1 . THR B 1 142 ? -16.404 6.863   138.325 1.00 109.10 ? 142 THR B OG1 1 
ATOM 2287 C CG2 . THR B 1 142 ? -16.271 7.380   140.668 1.00 109.10 ? 142 THR B CG2 1 
ATOM 2288 N N   . LEU B 1 143 ? -13.005 6.379   140.651 1.00 113.78 ? 143 LEU B N   1 
ATOM 2289 C CA  . LEU B 1 143 ? -11.729 7.141   140.683 1.00 113.78 ? 143 LEU B CA  1 
ATOM 2290 C C   . LEU B 1 143 ? -10.573 6.154   140.882 1.00 113.78 ? 143 LEU B C   1 
ATOM 2291 O O   . LEU B 1 143 ? -10.415 5.651   142.004 1.00 113.78 ? 143 LEU B O   1 
ATOM 2292 C CB  . LEU B 1 143 ? -11.785 8.166   141.817 1.00 113.78 ? 143 LEU B CB  1 
ATOM 2293 C CG  . LEU B 1 143 ? -11.281 9.559   141.453 1.00 113.78 ? 143 LEU B CG  1 
ATOM 2294 C CD1 . LEU B 1 143 ? -12.089 10.143  140.307 1.00 113.78 ? 143 LEU B CD1 1 
ATOM 2295 C CD2 . LEU B 1 143 ? -11.319 10.478  142.662 1.00 113.78 ? 143 LEU B CD2 1 
ATOM 2296 N N   . PRO B 1 144 ? -9.758  5.853   139.850 1.00 123.59 ? 144 PRO B N   1 
ATOM 2297 C CA  . PRO B 1 144 ? -8.699  4.842   139.976 1.00 123.59 ? 144 PRO B CA  1 
ATOM 2298 C C   . PRO B 1 144 ? -7.505  5.254   140.848 1.00 123.59 ? 144 PRO B C   1 
ATOM 2299 O O   . PRO B 1 144 ? -7.042  4.412   141.595 1.00 123.59 ? 144 PRO B O   1 
ATOM 2300 C CB  . PRO B 1 144 ? -8.224  4.657   138.526 1.00 123.59 ? 144 PRO B CB  1 
ATOM 2301 C CG  . PRO B 1 144 ? -8.511  5.989   137.874 1.00 123.59 ? 144 PRO B CG  1 
ATOM 2302 C CD  . PRO B 1 144 ? -9.797  6.460   138.520 1.00 123.59 ? 144 PRO B CD  1 
ATOM 2303 N N   . GLU B 1 145 ? -7.033  6.500   140.744 1.00 123.87 ? 145 GLU B N   1 
ATOM 2304 C CA  . GLU B 1 145 ? -5.816  6.949   141.476 1.00 123.87 ? 145 GLU B CA  1 
ATOM 2305 C C   . GLU B 1 145 ? -6.086  8.221   142.285 1.00 123.87 ? 145 GLU B C   1 
ATOM 2306 O O   . GLU B 1 145 ? -5.082  8.819   142.715 1.00 123.87 ? 145 GLU B O   1 
ATOM 2307 C CB  . GLU B 1 145 ? -4.681  7.199   140.483 1.00 123.87 ? 145 GLU B CB  1 
ATOM 2308 C CG  . GLU B 1 145 ? -3.307  6.892   141.045 1.00 123.87 ? 145 GLU B CG  1 
ATOM 2309 C CD  . GLU B 1 145 ? -3.042  5.418   141.295 1.00 123.87 ? 145 GLU B CD  1 
ATOM 2310 O OE1 . GLU B 1 145 ? -3.922  4.596   140.970 1.00 123.87 ? 145 GLU B OE1 1 
ATOM 2311 O OE2 . GLU B 1 145 ? -1.955  5.095   141.814 1.00 123.87 ? 145 GLU B OE2 1 
ATOM 2312 N N   . THR B 1 146 ? -7.345  8.661   142.421 1.00 114.93 ? 146 THR B N   1 
ATOM 2313 C CA  . THR B 1 146 ? -7.716  9.822   143.228 1.00 114.93 ? 146 THR B CA  1 
ATOM 2314 C C   . THR B 1 146 ? -6.760  10.999  143.039 1.00 114.93 ? 146 THR B C   1 
ATOM 2315 O O   . THR B 1 146 ? -6.566  11.804  143.953 1.00 114.93 ? 146 THR B O   1 
ATOM 2316 C CB  . THR B 1 146 ? -7.801  9.444   144.709 1.00 114.93 ? 146 THR B CB  1 
ATOM 2317 O OG1 . THR B 1 146 ? -6.484  9.190   145.217 1.00 114.93 ? 146 THR B OG1 1 
ATOM 2318 C CG2 . THR B 1 146 ? -8.659  8.199   144.893 1.00 114.93 ? 146 THR B CG2 1 
ATOM 2319 N N   . THR B 1 147 ? -6.140  11.112  141.867 1.00 118.45 ? 147 THR B N   1 
ATOM 2320 C CA  . THR B 1 147 ? -5.524  12.362  141.436 1.00 118.45 ? 147 THR B CA  1 
ATOM 2321 C C   . THR B 1 147 ? -6.178  12.812  140.137 1.00 118.45 ? 147 THR B C   1 
ATOM 2322 O O   . THR B 1 147 ? -6.108  12.103  139.129 1.00 118.45 ? 147 THR B O   1 
ATOM 2323 C CB  . THR B 1 147 ? -4.014  12.198  141.249 1.00 118.45 ? 147 THR B CB  1 
ATOM 2324 O OG1 . THR B 1 147 ? -3.431  11.691  142.457 1.00 118.45 ? 147 THR B OG1 1 
ATOM 2325 C CG2 . THR B 1 147 ? -3.368  13.531  140.902 1.00 118.45 ? 147 THR B CG2 1 
ATOM 2326 N N   . VAL B 1 148 ? -6.805  13.984  140.161 1.00 112.46 ? 148 VAL B N   1 
ATOM 2327 C CA  . VAL B 1 148 ? -7.659  14.435  139.068 1.00 112.46 ? 148 VAL B CA  1 
ATOM 2328 C C   . VAL B 1 148 ? -6.894  15.492  138.284 1.00 112.46 ? 148 VAL B C   1 
ATOM 2329 O O   . VAL B 1 148 ? -6.570  16.559  138.821 1.00 112.46 ? 148 VAL B O   1 
ATOM 2330 C CB  . VAL B 1 148 ? -8.996  14.986  139.589 1.00 112.46 ? 148 VAL B CB  1 
ATOM 2331 C CG1 . VAL B 1 148 ? -9.867  15.462  138.434 1.00 112.46 ? 148 VAL B CG1 1 
ATOM 2332 C CG2 . VAL B 1 148 ? -9.720  13.929  140.407 1.00 112.46 ? 148 VAL B CG2 1 
ATOM 2333 N N   . VAL B 1 149 ? -6.554  15.205  137.026 1.00 119.70 ? 149 VAL B N   1 
ATOM 2334 C CA  . VAL B 1 149 ? -5.792  16.156  136.162 1.00 119.70 ? 149 VAL B CA  1 
ATOM 2335 C C   . VAL B 1 149 ? -6.676  16.539  134.976 1.00 119.70 ? 149 VAL B C   1 
ATOM 2336 O O   . VAL B 1 149 ? -7.553  15.730  134.625 1.00 119.70 ? 149 VAL B O   1 
ATOM 2337 C CB  . VAL B 1 149 ? -4.449  15.552  135.713 1.00 119.70 ? 149 VAL B CB  1 
ATOM 2338 C CG1 . VAL B 1 149 ? -3.688  16.495  134.797 1.00 119.70 ? 149 VAL B CG1 1 
ATOM 2339 C CG2 . VAL B 1 149 ? -3.593  15.161  136.906 1.00 119.70 ? 149 VAL B CG2 1 
ATOM 2340 N N   . ARG B 1 150 ? -6.489  17.737  134.415 1.00 120.09 ? 150 ARG B N   1 
ATOM 2341 C CA  . ARG B 1 150 ? -7.251  18.200  133.226 1.00 120.09 ? 150 ARG B CA  1 
ATOM 2342 C C   . ARG B 1 150 ? -7.468  17.010  132.290 1.00 120.09 ? 150 ARG B C   1 
ATOM 2343 O O   . ARG B 1 150 ? -6.464  16.364  131.930 1.00 120.09 ? 150 ARG B O   1 
ATOM 2344 C CB  . ARG B 1 150 ? -6.483  19.310  132.506 1.00 120.09 ? 150 ARG B CB  1 
ATOM 2345 C CG  . ARG B 1 150 ? -7.178  19.848  131.264 1.00 120.09 ? 150 ARG B CG  1 
ATOM 2346 C CD  . ARG B 1 150 ? -8.250  20.871  131.582 1.00 120.09 ? 150 ARG B CD  1 
ATOM 2347 N NE  . ARG B 1 150 ? -7.698  22.067  132.207 1.00 120.09 ? 150 ARG B NE  1 
ATOM 2348 C CZ  . ARG B 1 150 ? -8.306  23.246  132.262 1.00 120.09 ? 150 ARG B CZ  1 
ATOM 2349 N NH1 . ARG B 1 150 ? -9.499  23.414  131.717 1.00 120.09 ? 150 ARG B NH1 1 
ATOM 2350 N NH2 . ARG B 1 150 ? -7.714  24.263  132.860 1.00 120.09 ? 150 ARG B NH2 1 
ATOM 2351 N N   . ARG B 1 151 ? -8.715  16.732  131.904 1.00 30.00  ? 151 ARG B N   1 
ATOM 2352 C CA  . ARG B 1 151 ? -9.044  15.597  131.002 1.00 30.00  ? 151 ARG B CA  1 
ATOM 2353 C C   . ARG B 1 151 ? -8.477  15.882  129.608 1.00 30.00  ? 151 ARG B C   1 
ATOM 2354 O O   . ARG B 1 151 ? -8.570  17.049  129.180 1.00 30.00  ? 151 ARG B O   1 
ATOM 2355 C CB  . ARG B 1 151 ? -10.559 15.379  130.956 1.00 30.00  ? 151 ARG B CB  1 
ATOM 2356 C CG  . ARG B 1 151 ? -11.163 14.965  132.289 1.00 30.00  ? 151 ARG B CG  1 
ATOM 2357 C CD  . ARG B 1 151 ? -12.456 14.193  132.114 1.00 30.00  ? 151 ARG B CD  1 
ATOM 2358 N NE  . ARG B 1 151 ? -12.260 12.975  131.342 1.00 30.00  ? 151 ARG B NE  1 
ATOM 2359 C CZ  . ARG B 1 151 ? -13.222 12.117  131.022 1.00 30.00  ? 151 ARG B CZ  1 
ATOM 2360 N NH1 . ARG B 1 151 ? -14.470 12.337  131.405 1.00 30.00  ? 151 ARG B NH1 1 
ATOM 2361 N NH2 . ARG B 1 151 ? -12.934 11.039  130.316 1.00 30.00  ? 151 ARG B NH2 1 
ATOM 2362 N N   . ARG B 1 152 ? -7.916  14.873  128.931 1.00 30.00  ? 152 ARG B N   1 
ATOM 2363 C CA  . ARG B 1 152 ? -7.335  15.018  127.569 1.00 30.00  ? 152 ARG B CA  1 
ATOM 2364 C C   . ARG B 1 152 ? -7.267  16.504  127.194 1.00 30.00  ? 152 ARG B C   1 
ATOM 2365 O O   . ARG B 1 152 ? -8.132  16.943  126.412 1.00 30.00  ? 152 ARG B O   1 
ATOM 2366 C CB  . ARG B 1 152 ? -8.166  14.200  126.578 1.00 30.00  ? 152 ARG B CB  1 
ATOM 2367 C CG  . ARG B 1 152 ? -7.418  13.794  125.319 1.00 30.00  ? 152 ARG B CG  1 
ATOM 2368 C CD  . ARG B 1 152 ? -6.270  12.854  125.629 1.00 30.00  ? 152 ARG B CD  1 
ATOM 2369 N NE  . ARG B 1 152 ? -5.822  12.134  124.446 1.00 30.00  ? 152 ARG B NE  1 
ATOM 2370 C CZ  . ARG B 1 152 ? -6.385  11.027  123.973 1.00 30.00  ? 152 ARG B CZ  1 
ATOM 2371 N NH1 . ARG B 1 152 ? -7.438  10.499  124.573 1.00 30.00  ? 152 ARG B NH1 1 
ATOM 2372 N NH2 . ARG B 1 152 ? -5.892  10.451  122.891 1.00 30.00  ? 152 ARG B NH2 1 
ATOM 2373 N N   . MET C 1 1   ? -38.281 37.045  141.923 1.00 109.91 ? 1   MET C N   1 
ATOM 2374 C CA  . MET C 1 1   ? -37.757 36.256  140.781 1.00 109.91 ? 1   MET C CA  1 
ATOM 2375 C C   . MET C 1 1   ? -36.793 35.195  141.311 1.00 109.91 ? 1   MET C C   1 
ATOM 2376 O O   . MET C 1 1   ? -35.964 35.545  142.167 1.00 109.91 ? 1   MET C O   1 
ATOM 2377 C CB  . MET C 1 1   ? -37.015 37.155  139.790 1.00 109.91 ? 1   MET C CB  1 
ATOM 2378 C CG  . MET C 1 1   ? -37.867 38.254  139.199 1.00 109.91 ? 1   MET C CG  1 
ATOM 2379 S SD  . MET C 1 1   ? -36.881 39.382  138.185 1.00 109.91 ? 1   MET C SD  1 
ATOM 2380 C CE  . MET C 1 1   ? -36.242 38.236  136.965 1.00 109.91 ? 1   MET C CE  1 
ATOM 2381 N N   . ASP C 1 2   ? -36.887 33.955  140.824 1.00 111.92 ? 2   ASP C N   1 
ATOM 2382 C CA  . ASP C 1 2   ? -36.019 32.838  141.276 1.00 111.92 ? 2   ASP C CA  1 
ATOM 2383 C C   . ASP C 1 2   ? -34.789 32.761  140.376 1.00 111.92 ? 2   ASP C C   1 
ATOM 2384 O O   . ASP C 1 2   ? -34.943 32.305  139.230 1.00 111.92 ? 2   ASP C O   1 
ATOM 2385 C CB  . ASP C 1 2   ? -36.766 31.508  141.271 1.00 111.92 ? 2   ASP C CB  1 
ATOM 2386 C CG  . ASP C 1 2   ? -35.855 30.302  141.424 1.00 111.92 ? 2   ASP C CG  1 
ATOM 2387 O OD1 . ASP C 1 2   ? -34.733 30.478  141.937 1.00 111.92 ? 2   ASP C OD1 1 
ATOM 2388 O OD2 . ASP C 1 2   ? -36.271 29.199  141.023 1.00 111.92 ? 2   ASP C OD2 1 
ATOM 2389 N N   . ILE C 1 3   ? -33.623 33.178  140.869 1.00 102.69 ? 3   ILE C N   1 
ATOM 2390 C CA  . ILE C 1 3   ? -32.352 33.148  140.092 1.00 102.69 ? 3   ILE C CA  1 
ATOM 2391 C C   . ILE C 1 3   ? -31.372 32.243  140.836 1.00 102.69 ? 3   ILE C C   1 
ATOM 2392 O O   . ILE C 1 3   ? -31.279 32.383  142.065 1.00 102.69 ? 3   ILE C O   1 
ATOM 2393 C CB  . ILE C 1 3   ? -31.796 34.571  139.895 1.00 102.69 ? 3   ILE C CB  1 
ATOM 2394 C CG1 . ILE C 1 3   ? -32.824 35.500  139.246 1.00 102.69 ? 3   ILE C CG1 1 
ATOM 2395 C CG2 . ILE C 1 3   ? -30.497 34.533  139.108 1.00 102.69 ? 3   ILE C CG2 1 
ATOM 2396 C CD1 . ILE C 1 3   ? -32.366 36.936  139.136 1.00 102.69 ? 3   ILE C CD1 1 
ATOM 2397 N N   . ASP C 1 4   ? -30.690 31.338  140.133 1.00 100.60 ? 4   ASP C N   1 
ATOM 2398 C CA  . ASP C 1 4   ? -29.692 30.418  140.741 1.00 100.60 ? 4   ASP C CA  1 
ATOM 2399 C C   . ASP C 1 4   ? -28.316 30.813  140.212 1.00 100.60 ? 4   ASP C C   1 
ATOM 2400 O O   . ASP C 1 4   ? -28.145 30.818  138.984 1.00 100.60 ? 4   ASP C O   1 
ATOM 2401 C CB  . ASP C 1 4   ? -30.050 28.963  140.440 1.00 100.60 ? 4   ASP C CB  1 
ATOM 2402 C CG  . ASP C 1 4   ? -29.045 27.939  140.938 1.00 100.60 ? 4   ASP C CG  1 
ATOM 2403 O OD1 . ASP C 1 4   ? -27.995 28.349  141.459 1.00 100.60 ? 4   ASP C OD1 1 
ATOM 2404 O OD2 . ASP C 1 4   ? -29.327 26.733  140.802 1.00 100.60 ? 4   ASP C OD2 1 
ATOM 2405 N N   . PRO C 1 5   ? -27.332 31.125  141.077 1.00 96.13  ? 5   PRO C N   1 
ATOM 2406 C CA  . PRO C 1 5   ? -26.035 31.607  140.610 1.00 96.13  ? 5   PRO C CA  1 
ATOM 2407 C C   . PRO C 1 5   ? -25.207 30.619  139.774 1.00 96.13  ? 5   PRO C C   1 
ATOM 2408 O O   . PRO C 1 5   ? -24.267 31.074  139.164 1.00 96.13  ? 5   PRO C O   1 
ATOM 2409 C CB  . PRO C 1 5   ? -25.298 31.894  141.924 1.00 96.13  ? 5   PRO C CB  1 
ATOM 2410 C CG  . PRO C 1 5   ? -25.959 30.989  142.925 1.00 96.13  ? 5   PRO C CG  1 
ATOM 2411 C CD  . PRO C 1 5   ? -27.415 31.055  142.534 1.00 96.13  ? 5   PRO C CD  1 
ATOM 2412 N N   . TYR C 1 6   ? -25.559 29.333  139.732 1.00 94.30  ? 6   TYR C N   1 
ATOM 2413 C CA  . TYR C 1 6   ? -24.754 28.302  139.025 1.00 94.30  ? 6   TYR C CA  1 
ATOM 2414 C C   . TYR C 1 6   ? -25.493 27.696  137.833 1.00 94.30  ? 6   TYR C C   1 
ATOM 2415 O O   . TYR C 1 6   ? -24.845 26.945  137.091 1.00 94.30  ? 6   TYR C O   1 
ATOM 2416 C CB  . TYR C 1 6   ? -24.386 27.172  139.986 1.00 94.30  ? 6   TYR C CB  1 
ATOM 2417 C CG  . TYR C 1 6   ? -23.787 27.615  141.294 1.00 94.30  ? 6   TYR C CG  1 
ATOM 2418 C CD1 . TYR C 1 6   ? -22.455 27.975  141.384 1.00 94.30  ? 6   TYR C CD1 1 
ATOM 2419 C CD2 . TYR C 1 6   ? -24.550 27.657  142.447 1.00 94.30  ? 6   TYR C CD2 1 
ATOM 2420 C CE1 . TYR C 1 6   ? -21.897 28.378  142.584 1.00 94.30  ? 6   TYR C CE1 1 
ATOM 2421 C CE2 . TYR C 1 6   ? -24.008 28.058  143.655 1.00 94.30  ? 6   TYR C CE2 1 
ATOM 2422 C CZ  . TYR C 1 6   ? -22.676 28.419  143.724 1.00 94.30  ? 6   TYR C CZ  1 
ATOM 2423 O OH  . TYR C 1 6   ? -22.131 28.817  144.909 1.00 94.30  ? 6   TYR C OH  1 
ATOM 2424 N N   . LYS C 1 7   ? -26.776 27.996  137.633 1.00 98.41  ? 7   LYS C N   1 
ATOM 2425 C CA  . LYS C 1 7   ? -27.591 27.366  136.558 1.00 98.41  ? 7   LYS C CA  1 
ATOM 2426 C C   . LYS C 1 7   ? -27.051 27.764  135.184 1.00 98.41  ? 7   LYS C C   1 
ATOM 2427 O O   . LYS C 1 7   ? -27.034 26.902  134.294 1.00 98.41  ? 7   LYS C O   1 
ATOM 2428 C CB  . LYS C 1 7   ? -29.059 27.763  136.706 1.00 98.41  ? 7   LYS C CB  1 
ATOM 2429 C CG  . LYS C 1 7   ? -30.037 26.915  135.908 1.00 98.41  ? 7   LYS C CG  1 
ATOM 2430 C CD  . LYS C 1 7   ? -30.930 27.725  135.002 1.00 98.41  ? 7   LYS C CD  1 
ATOM 2431 C CE  . LYS C 1 7   ? -32.007 26.892  134.344 1.00 98.41  ? 7   LYS C CE  1 
ATOM 2432 N NZ  . LYS C 1 7   ? -32.917 27.736  133.538 1.00 98.41  ? 7   LYS C NZ  1 
ATOM 2433 N N   . GLU C 1 8   ? -26.638 29.016  135.006 1.00 98.97  ? 8   GLU C N   1 
ATOM 2434 C CA  . GLU C 1 8   ? -26.059 29.505  133.729 1.00 98.97  ? 8   GLU C CA  1 
ATOM 2435 C C   . GLU C 1 8   ? -24.831 28.664  133.404 1.00 98.97  ? 8   GLU C C   1 
ATOM 2436 O O   . GLU C 1 8   ? -24.502 28.560  132.212 1.00 98.97  ? 8   GLU C O   1 
ATOM 2437 C CB  . GLU C 1 8   ? -25.681 30.978  133.871 1.00 98.97  ? 8   GLU C CB  1 
ATOM 2438 C CG  . GLU C 1 8   ? -24.809 31.515  132.753 1.00 98.97  ? 8   GLU C CG  1 
ATOM 2439 C CD  . GLU C 1 8   ? -24.317 32.932  132.994 1.00 98.97  ? 8   GLU C CD  1 
ATOM 2440 O OE1 . GLU C 1 8   ? -23.356 33.345  132.321 1.00 98.97  ? 8   GLU C OE1 1 
ATOM 2441 O OE2 . GLU C 1 8   ? -24.892 33.614  133.861 1.00 98.97  ? 8   GLU C OE2 1 
ATOM 2442 N N   . PHE C 1 9   ? -24.159 28.106  134.416 1.00 93.96  ? 9   PHE C N   1 
ATOM 2443 C CA  . PHE C 1 9   ? -22.911 27.318  134.235 1.00 93.96  ? 9   PHE C CA  1 
ATOM 2444 C C   . PHE C 1 9   ? -23.243 25.826  134.190 1.00 93.96  ? 9   PHE C C   1 
ATOM 2445 O O   . PHE C 1 9   ? -22.377 25.046  133.754 1.00 93.96  ? 9   PHE C O   1 
ATOM 2446 C CB  . PHE C 1 9   ? -21.923 27.644  135.357 1.00 93.96  ? 9   PHE C CB  1 
ATOM 2447 C CG  . PHE C 1 9   ? -21.548 29.101  135.442 1.00 93.96  ? 9   PHE C CG  1 
ATOM 2448 C CD1 . PHE C 1 9   ? -20.316 29.546  134.987 1.00 93.96  ? 9   PHE C CD1 1 
ATOM 2449 C CD2 . PHE C 1 9   ? -22.435 30.031  135.960 1.00 93.96  ? 9   PHE C CD2 1 
ATOM 2450 C CE1 . PHE C 1 9   ? -19.976 30.888  135.061 1.00 93.96  ? 9   PHE C CE1 1 
ATOM 2451 C CE2 . PHE C 1 9   ? -22.093 31.371  136.031 1.00 93.96  ? 9   PHE C CE2 1 
ATOM 2452 C CZ  . PHE C 1 9   ? -20.866 31.797  135.580 1.00 93.96  ? 9   PHE C CZ  1 
ATOM 2453 N N   . GLY C 1 10  ? -24.447 25.439  134.623 1.00 94.70  ? 10  GLY C N   1 
ATOM 2454 C CA  . GLY C 1 10  ? -24.879 24.028  134.631 1.00 94.70  ? 10  GLY C CA  1 
ATOM 2455 C C   . GLY C 1 10  ? -24.791 23.440  136.025 1.00 94.70  ? 10  GLY C C   1 
ATOM 2456 O O   . GLY C 1 10  ? -25.465 22.420  136.269 1.00 94.70  ? 10  GLY C O   1 
ATOM 2457 N N   . ALA C 1 11  ? -24.009 24.052  136.918 1.00 95.42  ? 11  ALA C N   1 
ATOM 2458 C CA  . ALA C 1 11  ? -23.873 23.600  138.322 1.00 95.42  ? 11  ALA C CA  1 
ATOM 2459 C C   . ALA C 1 11  ? -25.141 23.995  139.082 1.00 95.42  ? 11  ALA C C   1 
ATOM 2460 O O   . ALA C 1 11  ? -25.863 24.879  138.582 1.00 95.42  ? 11  ALA C O   1 
ATOM 2461 C CB  . ALA C 1 11  ? -22.627 24.186  138.941 1.00 95.42  ? 11  ALA C CB  1 
ATOM 2462 N N   . THR C 1 12  ? -25.424 23.358  140.219 1.00 100.07 ? 12  THR C N   1 
ATOM 2463 C CA  . THR C 1 12  ? -26.644 23.631  141.024 1.00 100.07 ? 12  THR C CA  1 
ATOM 2464 C C   . THR C 1 12  ? -26.267 23.801  142.493 1.00 100.07 ? 12  THR C C   1 
ATOM 2465 O O   . THR C 1 12  ? -25.289 23.168  142.914 1.00 100.07 ? 12  THR C O   1 
ATOM 2466 C CB  . THR C 1 12  ? -27.663 22.494  140.888 1.00 100.07 ? 12  THR C CB  1 
ATOM 2467 O OG1 . THR C 1 12  ? -27.140 21.358  141.578 1.00 100.07 ? 12  THR C OG1 1 
ATOM 2468 C CG2 . THR C 1 12  ? -27.956 22.138  139.448 1.00 100.07 ? 12  THR C CG2 1 
ATOM 2469 N N   . VAL C 1 13  ? -27.034 24.584  143.254 1.00 97.83  ? 13  VAL C N   1 
ATOM 2470 C CA  . VAL C 1 13  ? -26.788 24.780  144.712 1.00 97.83  ? 13  VAL C CA  1 
ATOM 2471 C C   . VAL C 1 13  ? -27.008 23.432  145.405 1.00 97.83  ? 13  VAL C C   1 
ATOM 2472 O O   . VAL C 1 13  ? -26.589 23.305  146.568 1.00 97.83  ? 13  VAL C O   1 
ATOM 2473 C CB  . VAL C 1 13  ? -27.686 25.888  145.295 1.00 97.83  ? 13  VAL C CB  1 
ATOM 2474 C CG1 . VAL C 1 13  ? -27.447 26.081  146.784 1.00 97.83  ? 13  VAL C CG1 1 
ATOM 2475 C CG2 . VAL C 1 13  ? -27.503 27.202  144.551 1.00 97.83  ? 13  VAL C CG2 1 
ATOM 2476 N N   . GLU C 1 14  ? -27.646 22.470  144.728 1.00 100.56 ? 14  GLU C N   1 
ATOM 2477 C CA  . GLU C 1 14  ? -27.867 21.100  145.268 1.00 100.56 ? 14  GLU C CA  1 
ATOM 2478 C C   . GLU C 1 14  ? -26.590 20.282  145.052 1.00 100.56 ? 14  GLU C C   1 
ATOM 2479 O O   . GLU C 1 14  ? -26.389 19.304  145.797 1.00 100.56 ? 14  GLU C O   1 
ATOM 2480 C CB  . GLU C 1 14  ? -29.077 20.467  144.580 1.00 100.56 ? 14  GLU C CB  1 
ATOM 2481 C CG  . GLU C 1 14  ? -29.250 18.985  144.865 1.00 100.56 ? 14  GLU C CG  1 
ATOM 2482 C CD  . GLU C 1 14  ? -29.538 18.631  146.314 1.00 100.56 ? 14  GLU C CD  1 
ATOM 2483 O OE1 . GLU C 1 14  ? -29.657 19.558  147.139 1.00 100.56 ? 14  GLU C OE1 1 
ATOM 2484 O OE2 . GLU C 1 14  ? -29.647 17.425  146.613 1.00 100.56 ? 14  GLU C OE2 1 
ATOM 2485 N N   . LEU C 1 15  ? -25.760 20.665  144.078 1.00 94.34  ? 15  LEU C N   1 
ATOM 2486 C CA  . LEU C 1 15  ? -24.481 19.967  143.779 1.00 94.34  ? 15  LEU C CA  1 
ATOM 2487 C C   . LEU C 1 15  ? -23.389 20.511  144.701 1.00 94.34  ? 15  LEU C C   1 
ATOM 2488 O O   . LEU C 1 15  ? -22.486 19.732  145.058 1.00 94.34  ? 15  LEU C O   1 
ATOM 2489 C CB  . LEU C 1 15  ? -24.122 20.201  142.308 1.00 94.34  ? 15  LEU C CB  1 
ATOM 2490 C CG  . LEU C 1 15  ? -22.739 19.709  141.881 1.00 94.34  ? 15  LEU C CG  1 
ATOM 2491 C CD1 . LEU C 1 15  ? -22.654 18.195  141.968 1.00 94.34  ? 15  LEU C CD1 1 
ATOM 2492 C CD2 . LEU C 1 15  ? -22.407 20.181  140.476 1.00 94.34  ? 15  LEU C CD2 1 
ATOM 2493 N N   . LEU C 1 16  ? -23.473 21.789  145.082 1.00 93.22  ? 16  LEU C N   1 
ATOM 2494 C CA  . LEU C 1 16  ? -22.452 22.441  145.938 1.00 93.22  ? 16  LEU C CA  1 
ATOM 2495 C C   . LEU C 1 16  ? -22.756 22.087  147.392 1.00 93.22  ? 16  LEU C C   1 
ATOM 2496 O O   . LEU C 1 16  ? -21.795 21.884  148.143 1.00 93.22  ? 16  LEU C O   1 
ATOM 2497 C CB  . LEU C 1 16  ? -22.457 23.950  145.681 1.00 93.22  ? 16  LEU C CB  1 
ATOM 2498 C CG  . LEU C 1 16  ? -21.718 24.405  144.425 1.00 93.22  ? 16  LEU C CG  1 
ATOM 2499 C CD1 . LEU C 1 16  ? -20.215 24.273  144.599 1.00 93.22  ? 16  LEU C CD1 1 
ATOM 2500 C CD2 . LEU C 1 16  ? -22.179 23.627  143.205 1.00 93.22  ? 16  LEU C CD2 1 
ATOM 2501 N N   . SER C 1 17  ? -24.029 22.002  147.784 1.00 96.45  ? 17  SER C N   1 
ATOM 2502 C CA  . SER C 1 17  ? -24.379 21.554  149.128 1.00 96.45  ? 17  SER C CA  1 
ATOM 2503 C C   . SER C 1 17  ? -23.881 20.142  149.389 1.00 96.45  ? 17  SER C C   1 
ATOM 2504 O O   . SER C 1 17  ? -23.709 19.753  150.549 1.00 96.45  ? 17  SER C O   1 
ATOM 2505 C CB  . SER C 1 17  ? -25.892 21.620  149.331 1.00 96.45  ? 17  SER C CB  1 
ATOM 2506 O OG  . SER C 1 17  ? -26.526 20.472  148.797 1.00 96.45  ? 17  SER C OG  1 
ATOM 2507 N N   . PHE C 1 18  ? -23.658 19.370  148.326 1.00 92.17  ? 18  PHE C N   1 
ATOM 2508 C CA  . PHE C 1 18  ? -23.296 17.965  148.464 1.00 92.17  ? 18  PHE C CA  1 
ATOM 2509 C C   . PHE C 1 18  ? -21.965 17.797  149.189 1.00 92.17  ? 18  PHE C C   1 
ATOM 2510 O O   . PHE C 1 18  ? -21.776 16.817  149.918 1.00 92.17  ? 18  PHE C O   1 
ATOM 2511 C CB  . PHE C 1 18  ? -23.246 17.321  147.077 1.00 92.17  ? 18  PHE C CB  1 
ATOM 2512 C CG  . PHE C 1 18  ? -23.244 15.818  147.091 1.00 92.17  ? 18  PHE C CG  1 
ATOM 2513 C CD1 . PHE C 1 18  ? -24.130 15.113  147.886 1.00 92.17  ? 18  PHE C CD1 1 
ATOM 2514 C CD2 . PHE C 1 18  ? -22.369 15.110  146.287 1.00 92.17  ? 18  PHE C CD2 1 
ATOM 2515 C CE1 . PHE C 1 18  ? -24.143 13.734  147.878 1.00 92.17  ? 18  PHE C CE1 1 
ATOM 2516 C CE2 . PHE C 1 18  ? -22.371 13.730  146.284 1.00 92.17  ? 18  PHE C CE2 1 
ATOM 2517 C CZ  . PHE C 1 18  ? -23.266 13.043  147.075 1.00 92.17  ? 18  PHE C CZ  1 
ATOM 2518 N N   . LEU C 1 19  ? -21.031 18.739  149.003 1.00 93.96  ? 19  LEU C N   1 
ATOM 2519 C CA  . LEU C 1 19  ? -19.759 18.746  149.713 1.00 93.96  ? 19  LEU C CA  1 
ATOM 2520 C C   . LEU C 1 19  ? -19.898 19.335  151.119 1.00 93.96  ? 19  LEU C C   1 
ATOM 2521 O O   . LEU C 1 19  ? -20.709 20.237  151.346 1.00 93.96  ? 19  LEU C O   1 
ATOM 2522 C CB  . LEU C 1 19  ? -18.743 19.571  148.933 1.00 93.96  ? 19  LEU C CB  1 
ATOM 2523 C CG  . LEU C 1 19  ? -17.967 18.884  147.811 1.00 93.96  ? 19  LEU C CG  1 
ATOM 2524 C CD1 . LEU C 1 19  ? -16.973 19.855  147.198 1.00 93.96  ? 19  LEU C CD1 1 
ATOM 2525 C CD2 . LEU C 1 19  ? -17.259 17.644  148.293 1.00 93.96  ? 19  LEU C CD2 1 
ATOM 2526 N N   . PRO C 1 20  ? -19.115 18.842  152.082 1.00 94.51  ? 20  PRO C N   1 
ATOM 2527 C CA  . PRO C 1 20  ? -19.237 19.340  153.457 1.00 94.51  ? 20  PRO C CA  1 
ATOM 2528 C C   . PRO C 1 20  ? -18.712 20.760  153.634 1.00 94.51  ? 20  PRO C C   1 
ATOM 2529 O O   . PRO C 1 20  ? -17.758 21.191  152.982 1.00 94.51  ? 20  PRO C O   1 
ATOM 2530 C CB  . PRO C 1 20  ? -18.407 18.338  154.267 1.00 94.51  ? 20  PRO C CB  1 
ATOM 2531 C CG  . PRO C 1 20  ? -17.376 17.862  153.311 1.00 94.51  ? 20  PRO C CG  1 
ATOM 2532 C CD  . PRO C 1 20  ? -18.046 17.837  151.959 1.00 94.51  ? 20  PRO C CD  1 
ATOM 2533 N N   . SER C 1 21  ? -19.362 21.481  154.551 1.00 99.71  ? 21  SER C N   1 
ATOM 2534 C CA  . SER C 1 21  ? -19.092 22.901  154.763 1.00 99.71  ? 21  SER C CA  1 
ATOM 2535 C C   . SER C 1 21  ? -17.634 23.206  155.108 1.00 99.71  ? 21  SER C C   1 
ATOM 2536 O O   . SER C 1 21  ? -17.124 24.269  154.741 1.00 99.71  ? 21  SER C O   1 
ATOM 2537 C CB  . SER C 1 21  ? -19.998 23.430  155.874 1.00 99.71  ? 21  SER C CB  1 
ATOM 2538 O OG  . SER C 1 21  ? -19.782 24.811  156.093 1.00 99.71  ? 21  SER C OG  1 
ATOM 2539 N N   . ASP C 1 22  ? -16.947 22.298  155.801 1.00 102.70 ? 22  ASP C N   1 
ATOM 2540 C CA  . ASP C 1 22  ? -15.551 22.501  156.185 1.00 102.70 ? 22  ASP C CA  1 
ATOM 2541 C C   . ASP C 1 22  ? -14.543 22.254  155.072 1.00 102.70 ? 22  ASP C C   1 
ATOM 2542 O O   . ASP C 1 22  ? -13.344 22.435  155.302 1.00 102.70 ? 22  ASP C O   1 
ATOM 2543 C CB  . ASP C 1 22  ? -15.209 21.597  157.370 1.00 102.70 ? 22  ASP C CB  1 
ATOM 2544 C CG  . ASP C 1 22  ? -15.881 22.037  158.654 1.00 102.70 ? 22  ASP C CG  1 
ATOM 2545 O OD1 . ASP C 1 22  ? -16.594 23.063  158.632 1.00 102.70 ? 22  ASP C OD1 1 
ATOM 2546 O OD2 . ASP C 1 22  ? -15.692 21.361  159.685 1.00 102.70 ? 22  ASP C OD2 1 
ATOM 2547 N N   . PHE C 1 23  ? -14.980 21.844  153.885 1.00 94.17  ? 23  PHE C N   1 
ATOM 2548 C CA  . PHE C 1 23  ? -14.037 21.591  152.801 1.00 94.17  ? 23  PHE C CA  1 
ATOM 2549 C C   . PHE C 1 23  ? -13.406 22.872  152.259 1.00 94.17  ? 23  PHE C C   1 
ATOM 2550 O O   . PHE C 1 23  ? -12.213 22.887  151.932 1.00 94.17  ? 23  PHE C O   1 
ATOM 2551 C CB  . PHE C 1 23  ? -14.732 20.826  151.678 1.00 94.17  ? 23  PHE C CB  1 
ATOM 2552 C CG  . PHE C 1 23  ? -13.878 20.637  150.462 1.00 94.17  ? 23  PHE C CG  1 
ATOM 2553 C CD1 . PHE C 1 23  ? -12.972 19.596  150.394 1.00 94.17  ? 23  PHE C CD1 1 
ATOM 2554 C CD2 . PHE C 1 23  ? -14.013 21.474  149.370 1.00 94.17  ? 23  PHE C CD2 1 
ATOM 2555 C CE1 . PHE C 1 23  ? -12.192 19.413  149.272 1.00 94.17  ? 23  PHE C CE1 1 
ATOM 2556 C CE2 . PHE C 1 23  ? -13.238 21.294  148.244 1.00 94.17  ? 23  PHE C CE2 1 
ATOM 2557 C CZ  . PHE C 1 23  ? -12.324 20.265  148.196 1.00 94.17  ? 23  PHE C CZ  1 
ATOM 2558 N N   . PHE C 1 24  ? -14.176 23.951  152.149 1.00 92.80  ? 24  PHE C N   1 
ATOM 2559 C CA  . PHE C 1 24  ? -13.704 25.124  151.416 1.00 92.80  ? 24  PHE C CA  1 
ATOM 2560 C C   . PHE C 1 24  ? -12.662 25.926  152.206 1.00 92.80  ? 24  PHE C C   1 
ATOM 2561 O O   . PHE C 1 24  ? -12.785 26.079  153.424 1.00 92.80  ? 24  PHE C O   1 
ATOM 2562 C CB  . PHE C 1 24  ? -14.890 26.011  151.071 1.00 92.80  ? 24  PHE C CB  1 
ATOM 2563 C CG  . PHE C 1 24  ? -15.936 25.305  150.263 1.00 92.80  ? 24  PHE C CG  1 
ATOM 2564 C CD1 . PHE C 1 24  ? -15.799 25.164  148.894 1.00 92.80  ? 24  PHE C CD1 1 
ATOM 2565 C CD2 . PHE C 1 24  ? -17.062 24.784  150.875 1.00 92.80  ? 24  PHE C CD2 1 
ATOM 2566 C CE1 . PHE C 1 24  ? -16.759 24.504  148.154 1.00 92.80  ? 24  PHE C CE1 1 
ATOM 2567 C CE2 . PHE C 1 24  ? -18.022 24.122  150.141 1.00 92.80  ? 24  PHE C CE2 1 
ATOM 2568 C CZ  . PHE C 1 24  ? -17.865 23.972  148.780 1.00 92.80  ? 24  PHE C CZ  1 
ATOM 2569 N N   . PRO C 1 25  ? -11.633 26.446  151.528 1.00 92.06  ? 25  PRO C N   1 
ATOM 2570 C CA  . PRO C 1 25  ? -10.633 27.303  152.185 1.00 92.06  ? 25  PRO C CA  1 
ATOM 2571 C C   . PRO C 1 25  ? -11.214 28.606  152.718 1.00 92.06  ? 25  PRO C C   1 
ATOM 2572 O O   . PRO C 1 25  ? -12.356 28.982  152.452 1.00 92.06  ? 25  PRO C O   1 
ATOM 2573 C CB  . PRO C 1 25  ? -9.611  27.576  151.076 1.00 92.06  ? 25  PRO C CB  1 
ATOM 2574 C CG  . PRO C 1 25  ? -9.762  26.455  150.137 1.00 92.06  ? 25  PRO C CG  1 
ATOM 2575 C CD  . PRO C 1 25  ? -11.223 26.115  150.154 1.00 92.06  ? 25  PRO C CD  1 
ATOM 2576 N N   . SER C 1 26  ? -10.384 29.303  153.494 1.00 99.28  ? 26  SER C N   1 
ATOM 2577 C CA  . SER C 1 26  ? -10.721 30.624  154.009 1.00 99.28  ? 26  SER C CA  1 
ATOM 2578 C C   . SER C 1 26  ? -10.652 31.684  152.906 1.00 99.28  ? 26  SER C C   1 
ATOM 2579 O O   . SER C 1 26  ? -9.967  31.532  151.892 1.00 99.28  ? 26  SER C O   1 
ATOM 2580 C CB  . SER C 1 26  ? -9.781  31.006  155.151 1.00 99.28  ? 26  SER C CB  1 
ATOM 2581 O OG  . SER C 1 26  ? -8.456  31.179  154.684 1.00 99.28  ? 26  SER C OG  1 
ATOM 2582 N N   . VAL C 1 27  ? -11.384 32.779  153.133 1.00 100.36 ? 27  VAL C N   1 
ATOM 2583 C CA  . VAL C 1 27  ? -11.481 33.862  152.153 1.00 100.36 ? 27  VAL C CA  1 
ATOM 2584 C C   . VAL C 1 27  ? -10.122 34.497  151.869 1.00 100.36 ? 27  VAL C C   1 
ATOM 2585 O O   . VAL C 1 27  ? -9.834  34.894  150.734 1.00 100.36 ? 27  VAL C O   1 
ATOM 2586 C CB  . VAL C 1 27  ? -12.494 34.921  152.630 1.00 100.36 ? 27  VAL C CB  1 
ATOM 2587 C CG1 . VAL C 1 27  ? -13.900 34.358  152.612 1.00 100.36 ? 27  VAL C CG1 1 
ATOM 2588 C CG2 . VAL C 1 27  ? -12.132 35.437  154.020 1.00 100.36 ? 27  VAL C CG2 1 
ATOM 2589 N N   . ARG C 1 28  ? -9.281  34.595  152.899 1.00 104.30 ? 28  ARG C N   1 
ATOM 2590 C CA  . ARG C 1 28  ? -7.941  35.216  152.765 1.00 104.30 ? 28  ARG C CA  1 
ATOM 2591 C C   . ARG C 1 28  ? -7.115  34.469  151.717 1.00 104.30 ? 28  ARG C C   1 
ATOM 2592 O O   . ARG C 1 28  ? -6.466  35.152  150.920 1.00 104.30 ? 28  ARG C O   1 
ATOM 2593 C CB  . ARG C 1 28  ? -7.209  35.223  154.106 1.00 104.30 ? 28  ARG C CB  1 
ATOM 2594 C CG  . ARG C 1 28  ? -7.750  36.235  155.101 1.00 104.30 ? 28  ARG C CG  1 
ATOM 2595 C CD  . ARG C 1 28  ? -6.954  36.202  156.386 1.00 104.30 ? 28  ARG C CD  1 
ATOM 2596 N NE  . ARG C 1 28  ? -7.315  37.278  157.296 1.00 104.30 ? 28  ARG C NE  1 
ATOM 2597 C CZ  . ARG C 1 28  ? -6.801  37.438  158.509 1.00 104.30 ? 28  ARG C CZ  1 
ATOM 2598 N NH1 . ARG C 1 28  ? -5.897  36.588  158.966 1.00 104.30 ? 28  ARG C NH1 1 
ATOM 2599 N NH2 . ARG C 1 28  ? -7.191  38.449  159.264 1.00 104.30 ? 28  ARG C NH2 1 
ATOM 2600 N N   . ASP C 1 29  ? -7.097  33.134  151.734 1.00 103.49 ? 29  ASP C N   1 
ATOM 2601 C CA  . ASP C 1 29  ? -6.349  32.354  150.751 1.00 103.49 ? 29  ASP C CA  1 
ATOM 2602 C C   . ASP C 1 29  ? -6.955  32.434  149.356 1.00 103.49 ? 29  ASP C C   1 
ATOM 2603 O O   . ASP C 1 29  ? -6.221  32.478  148.363 1.00 103.49 ? 29  ASP C O   1 
ATOM 2604 C CB  . ASP C 1 29  ? -6.263  30.898  151.207 1.00 103.49 ? 29  ASP C CB  1 
ATOM 2605 C CG  . ASP C 1 29  ? -5.380  30.722  152.426 1.00 103.49 ? 29  ASP C CG  1 
ATOM 2606 O OD1 . ASP C 1 29  ? -4.470  31.552  152.628 1.00 103.49 ? 29  ASP C OD1 1 
ATOM 2607 O OD2 . ASP C 1 29  ? -5.593  29.751  153.183 1.00 103.49 ? 29  ASP C OD2 1 
ATOM 2608 N N   . LEU C 1 30  ? -8.279  32.508  149.250 1.00 97.05  ? 30  LEU C N   1 
ATOM 2609 C CA  . LEU C 1 30  ? -8.891  32.576  147.926 1.00 97.05  ? 30  LEU C CA  1 
ATOM 2610 C C   . LEU C 1 30  ? -8.666  33.935  147.272 1.00 97.05  ? 30  LEU C C   1 
ATOM 2611 O O   . LEU C 1 30  ? -8.368  34.016  146.073 1.00 97.05  ? 30  LEU C O   1 
ATOM 2612 C CB  . LEU C 1 30  ? -10.385 32.273  148.035 1.00 97.05  ? 30  LEU C CB  1 
ATOM 2613 C CG  . LEU C 1 30  ? -10.741 30.848  148.463 1.00 97.05  ? 30  LEU C CG  1 
ATOM 2614 C CD1 . LEU C 1 30  ? -12.240 30.709  148.646 1.00 97.05  ? 30  LEU C CD1 1 
ATOM 2615 C CD2 . LEU C 1 30  ? -10.229 29.823  147.462 1.00 97.05  ? 30  LEU C CD2 1 
ATOM 2616 N N   . LEU C 1 31  ? -8.795  35.013  148.043 1.00 99.73  ? 31  LEU C N   1 
ATOM 2617 C CA  . LEU C 1 31  ? -8.471  36.343  147.541 1.00 99.73  ? 31  LEU C CA  1 
ATOM 2618 C C   . LEU C 1 31  ? -7.000  36.470  147.151 1.00 99.73  ? 31  LEU C C   1 
ATOM 2619 O O   . LEU C 1 31  ? -6.677  37.046  146.107 1.00 99.73  ? 31  LEU C O   1 
ATOM 2620 C CB  . LEU C 1 31  ? -8.840  37.398  148.582 1.00 99.73  ? 31  LEU C CB  1 
ATOM 2621 C CG  . LEU C 1 31  ? -10.340 37.632  148.764 1.00 99.73  ? 31  LEU C CG  1 
ATOM 2622 C CD1 . LEU C 1 31  ? -10.602 38.445  150.015 1.00 99.73  ? 31  LEU C CD1 1 
ATOM 2623 C CD2 . LEU C 1 31  ? -10.929 38.321  147.544 1.00 99.73  ? 31  LEU C CD2 1 
ATOM 2624 N N   . ASP C 1 32  ? -6.089  35.967  147.988 1.00 103.45 ? 32  ASP C N   1 
ATOM 2625 C CA  . ASP C 1 32  ? -4.682  35.927  147.595 1.00 103.45 ? 32  ASP C CA  1 
ATOM 2626 C C   . ASP C 1 32  ? -4.453  35.135  146.310 1.00 103.45 ? 32  ASP C C   1 
ATOM 2627 O O   . ASP C 1 32  ? -3.690  35.570  145.440 1.00 103.45 ? 32  ASP C O   1 
ATOM 2628 C CB  . ASP C 1 32  ? -3.846  35.340  148.730 1.00 103.45 ? 32  ASP C CB  1 
ATOM 2629 C CG  . ASP C 1 32  ? -3.749  36.269  149.923 1.00 103.45 ? 32  ASP C CG  1 
ATOM 2630 O OD1 . ASP C 1 32  ? -3.861  37.498  149.731 1.00 103.45 ? 32  ASP C OD1 1 
ATOM 2631 O OD2 . ASP C 1 32  ? -3.555  35.773  151.051 1.00 103.45 ? 32  ASP C OD2 1 
ATOM 2632 N N   . THR C 1 33  ? -5.090  33.972  146.168 1.00 100.92 ? 33  THR C N   1 
ATOM 2633 C CA  . THR C 1 33  ? -4.973  33.205  144.930 1.00 100.92 ? 33  THR C CA  1 
ATOM 2634 C C   . THR C 1 33  ? -5.436  34.008  143.718 1.00 100.92 ? 33  THR C C   1 
ATOM 2635 O O   . THR C 1 33  ? -4.760  34.039  142.680 1.00 100.92 ? 33  THR C O   1 
ATOM 2636 C CB  . THR C 1 33  ? -5.775  31.909  145.049 1.00 100.92 ? 33  THR C CB  1 
ATOM 2637 O OG1 . THR C 1 33  ? -5.285  31.141  146.155 1.00 100.92 ? 33  THR C OG1 1 
ATOM 2638 C CG2 . THR C 1 33  ? -5.660  31.083  143.777 1.00 100.92 ? 33  THR C CG2 1 
ATOM 2639 N N   . ALA C 1 34  ? -6.603  34.644  143.823 1.00 99.93  ? 34  ALA C N   1 
ATOM 2640 C CA  . ALA C 1 34  ? -7.116  35.452  142.720 1.00 99.93  ? 34  ALA C CA  1 
ATOM 2641 C C   . ALA C 1 34  ? -6.180  36.607  142.383 1.00 99.93  ? 34  ALA C C   1 
ATOM 2642 O O   . ALA C 1 34  ? -5.858  36.840  141.214 1.00 99.93  ? 34  ALA C O   1 
ATOM 2643 C CB  . ALA C 1 34  ? -8.508  35.976  143.070 1.00 99.93  ? 34  ALA C CB  1 
ATOM 2644 N N   . SER C 1 35  ? -5.719  37.333  143.399 1.00 103.26 ? 35  SER C N   1 
ATOM 2645 C CA  . SER C 1 35  ? -4.766  38.416  143.173 1.00 103.26 ? 35  SER C CA  1 
ATOM 2646 C C   . SER C 1 35  ? -3.497  37.924  142.490 1.00 103.26 ? 35  SER C C   1 
ATOM 2647 O O   . SER C 1 35  ? -2.974  38.584  141.584 1.00 103.26 ? 35  SER C O   1 
ATOM 2648 C CB  . SER C 1 35  ? -4.424  39.088  144.501 1.00 103.26 ? 35  SER C CB  1 
ATOM 2649 O OG  . SER C 1 35  ? -3.481  40.129  144.316 1.00 103.26 ? 35  SER C OG  1 
ATOM 2650 N N   . ALA C 1 36  ? -2.987  36.768  142.906 1.00 98.97  ? 36  ALA C N   1 
ATOM 2651 C CA  . ALA C 1 36  ? -1.771  36.228  142.306 1.00 98.97  ? 36  ALA C CA  1 
ATOM 2652 C C   . ALA C 1 36  ? -1.969  35.808  140.854 1.00 98.97  ? 36  ALA C C   1 
ATOM 2653 O O   . ALA C 1 36  ? -1.106  36.074  140.011 1.00 98.97  ? 36  ALA C O   1 
ATOM 2654 C CB  . ALA C 1 36  ? -1.270  35.046  143.134 1.00 98.97  ? 36  ALA C CB  1 
ATOM 2655 N N   . LEU C 1 37  ? -3.085  35.152  140.529 1.00 100.90 ? 37  LEU C N   1 
ATOM 2656 C CA  . LEU C 1 37  ? -3.217  34.573  139.193 1.00 100.90 ? 37  LEU C CA  1 
ATOM 2657 C C   . LEU C 1 37  ? -3.942  35.435  138.164 1.00 100.90 ? 37  LEU C C   1 
ATOM 2658 O O   . LEU C 1 37  ? -3.614  35.335  136.978 1.00 100.90 ? 37  LEU C O   1 
ATOM 2659 C CB  . LEU C 1 37  ? -3.932  33.220  139.281 1.00 100.90 ? 37  LEU C CB  1 
ATOM 2660 C CG  . LEU C 1 37  ? -3.168  32.117  140.016 1.00 100.90 ? 37  LEU C CG  1 
ATOM 2661 C CD1 . LEU C 1 37  ? -4.035  30.879  140.174 1.00 100.90 ? 37  LEU C CD1 1 
ATOM 2662 C CD2 . LEU C 1 37  ? -1.873  31.776  139.292 1.00 100.90 ? 37  LEU C CD2 1 
ATOM 2663 N N   . TYR C 1 38  ? -4.911  36.276  138.542 1.00 100.06 ? 38  TYR C N   1 
ATOM 2664 C CA  . TYR C 1 38  ? -5.839  36.825  137.558 1.00 100.06 ? 38  TYR C CA  1 
ATOM 2665 C C   . TYR C 1 38  ? -6.083  38.324  137.704 1.00 100.06 ? 38  TYR C C   1 
ATOM 2666 O O   . TYR C 1 38  ? -6.977  38.856  137.037 1.00 100.06 ? 38  TYR C O   1 
ATOM 2667 C CB  . TYR C 1 38  ? -7.175  36.078  137.622 1.00 100.06 ? 38  TYR C CB  1 
ATOM 2668 C CG  . TYR C 1 38  ? -7.033  34.586  137.434 1.00 100.06 ? 38  TYR C CG  1 
ATOM 2669 C CD1 . TYR C 1 38  ? -6.607  34.060  136.224 1.00 100.06 ? 38  TYR C CD1 1 
ATOM 2670 C CD2 . TYR C 1 38  ? -7.322  33.705  138.466 1.00 100.06 ? 38  TYR C CD2 1 
ATOM 2671 C CE1 . TYR C 1 38  ? -6.468  32.700  136.046 1.00 100.06 ? 38  TYR C CE1 1 
ATOM 2672 C CE2 . TYR C 1 38  ? -7.186  32.342  138.296 1.00 100.06 ? 38  TYR C CE2 1 
ATOM 2673 C CZ  . TYR C 1 38  ? -6.757  31.845  137.084 1.00 100.06 ? 38  TYR C CZ  1 
ATOM 2674 O OH  . TYR C 1 38  ? -6.631  30.487  136.907 1.00 100.06 ? 38  TYR C OH  1 
ATOM 2675 N N   . ARG C 1 39  ? -5.347  39.008  138.578 1.00 107.03 ? 39  ARG C N   1 
ATOM 2676 C CA  . ARG C 1 39  ? -5.564  40.435  138.804 1.00 107.03 ? 39  ARG C CA  1 
ATOM 2677 C C   . ARG C 1 39  ? -5.548  41.235  137.503 1.00 107.03 ? 39  ARG C C   1 
ATOM 2678 O O   . ARG C 1 39  ? -6.444  42.047  137.246 1.00 107.03 ? 39  ARG C O   1 
ATOM 2679 C CB  . ARG C 1 39  ? -4.517  40.956  139.789 1.00 107.03 ? 39  ARG C CB  1 
ATOM 2680 C CG  . ARG C 1 39  ? -4.572  42.450  140.058 1.00 107.03 ? 39  ARG C CG  1 
ATOM 2681 C CD  . ARG C 1 39  ? -3.417  42.886  140.949 1.00 107.03 ? 39  ARG C CD  1 
ATOM 2682 N NE  . ARG C 1 39  ? -2.109  42.704  140.331 1.00 107.03 ? 39  ARG C NE  1 
ATOM 2683 C CZ  . ARG C 1 39  ? -1.642  43.424  139.320 1.00 107.03 ? 39  ARG C CZ  1 
ATOM 2684 N NH1 . ARG C 1 39  ? -2.366  44.375  138.753 1.00 107.03 ? 39  ARG C NH1 1 
ATOM 2685 N NH2 . ARG C 1 39  ? -0.425  43.167  138.851 1.00 107.03 ? 39  ARG C NH2 1 
ATOM 2686 N N   . GLU C 1 40  ? -4.531  41.019  136.669 1.00 106.43 ? 40  GLU C N   1 
ATOM 2687 C CA  . GLU C 1 40  ? -4.411  41.754  135.411 1.00 106.43 ? 40  GLU C CA  1 
ATOM 2688 C C   . GLU C 1 40  ? -5.601  41.505  134.485 1.00 106.43 ? 40  GLU C C   1 
ATOM 2689 O O   . GLU C 1 40  ? -6.180  42.447  133.933 1.00 106.43 ? 40  GLU C O   1 
ATOM 2690 C CB  . GLU C 1 40  ? -3.103  41.379  134.717 1.00 106.43 ? 40  GLU C CB  1 
ATOM 2691 C CG  . GLU C 1 40  ? -2.924  42.010  133.347 1.00 106.43 ? 40  GLU C CG  1 
ATOM 2692 C CD  . GLU C 1 40  ? -1.573  41.700  132.738 1.00 106.43 ? 40  GLU C CD  1 
ATOM 2693 O OE1 . GLU C 1 40  ? -1.003  40.637  133.061 1.00 106.43 ? 40  GLU C OE1 1 
ATOM 2694 O OE2 . GLU C 1 40  ? -1.079  42.523  131.939 1.00 106.43 ? 40  GLU C OE2 1 
ATOM 2695 N N   . ALA C 1 41  ? -5.980  40.240  134.305 1.00 102.14 ? 41  ALA C N   1 
ATOM 2696 C CA  . ALA C 1 41  ? -7.123  39.910  133.454 1.00 102.14 ? 41  ALA C CA  1 
ATOM 2697 C C   . ALA C 1 41  ? -8.423  40.506  133.985 1.00 102.14 ? 41  ALA C C   1 
ATOM 2698 O O   . ALA C 1 41  ? -9.232  41.031  133.211 1.00 102.14 ? 41  ALA C O   1 
ATOM 2699 C CB  . ALA C 1 41  ? -7.248  38.393  133.318 1.00 102.14 ? 41  ALA C CB  1 
ATOM 2700 N N   . LEU C 1 42  ? -8.644  40.435  135.296 1.00 101.35 ? 42  LEU C N   1 
ATOM 2701 C CA  . LEU C 1 42  ? -9.835  41.039  135.888 1.00 101.35 ? 42  LEU C CA  1 
ATOM 2702 C C   . LEU C 1 42  ? -9.911  42.537  135.606 1.00 101.35 ? 42  LEU C C   1 
ATOM 2703 O O   . LEU C 1 42  ? -10.970 43.056  135.235 1.00 101.35 ? 42  LEU C O   1 
ATOM 2704 C CB  . LEU C 1 42  ? -9.848  40.784  137.395 1.00 101.35 ? 42  LEU C CB  1 
ATOM 2705 C CG  . LEU C 1 42  ? -10.149 39.354  137.848 1.00 101.35 ? 42  LEU C CG  1 
ATOM 2706 C CD1 . LEU C 1 42  ? -9.863  39.195  139.331 1.00 101.35 ? 42  LEU C CD1 1 
ATOM 2707 C CD2 . LEU C 1 42  ? -11.588 38.982  137.543 1.00 101.35 ? 42  LEU C CD2 1 
ATOM 2708 N N   . GLU C 1 43  ? -8.800  43.250  135.776 1.00 104.05 ? 43  GLU C N   1 
ATOM 2709 C CA  . GLU C 1 43  ? -8.756  44.675  135.459 1.00 104.05 ? 43  GLU C CA  1 
ATOM 2710 C C   . GLU C 1 43  ? -8.758  44.980  133.965 1.00 104.05 ? 43  GLU C C   1 
ATOM 2711 O O   . GLU C 1 43  ? -8.923  46.148  133.599 1.00 104.05 ? 43  GLU C O   1 
ATOM 2712 C CB  . GLU C 1 43  ? -7.513  45.310  136.081 1.00 104.05 ? 43  GLU C CB  1 
ATOM 2713 C CG  . GLU C 1 43  ? -7.541  45.382  137.591 1.00 104.05 ? 43  GLU C CG  1 
ATOM 2714 C CD  . GLU C 1 43  ? -6.322  46.078  138.154 1.00 104.05 ? 43  GLU C CD  1 
ATOM 2715 O OE1 . GLU C 1 43  ? -5.402  46.391  137.371 1.00 104.05 ? 43  GLU C OE1 1 
ATOM 2716 O OE2 . GLU C 1 43  ? -6.284  46.316  139.379 1.00 104.05 ? 43  GLU C OE2 1 
ATOM 2717 N N   . SER C 1 44  ? -8.648  43.961  133.110 1.00 107.18 ? 44  SER C N   1 
ATOM 2718 C CA  . SER C 1 44  ? -8.719  44.140  131.636 1.00 107.18 ? 44  SER C CA  1 
ATOM 2719 C C   . SER C 1 44  ? -10.111 44.665  131.267 1.00 107.18 ? 44  SER C C   1 
ATOM 2720 O O   . SER C 1 44  ? -11.085 44.253  131.925 1.00 107.18 ? 44  SER C O   1 
ATOM 2721 C CB  . SER C 1 44  ? -8.398  42.861  130.915 1.00 107.18 ? 44  SER C CB  1 
ATOM 2722 O OG  . SER C 1 44  ? -9.367  41.866  131.204 1.00 107.18 ? 44  SER C OG  1 
ATOM 2723 N N   . PRO C 1 45  ? -10.255 45.558  130.261 1.00 106.21 ? 45  PRO C N   1 
ATOM 2724 C CA  . PRO C 1 45  ? -11.554 46.158  129.930 1.00 106.21 ? 45  PRO C CA  1 
ATOM 2725 C C   . PRO C 1 45  ? -12.419 45.277  129.022 1.00 106.21 ? 45  PRO C C   1 
ATOM 2726 O O   . PRO C 1 45  ? -13.492 45.718  128.654 1.00 106.21 ? 45  PRO C O   1 
ATOM 2727 C CB  . PRO C 1 45  ? -11.161 47.429  129.165 1.00 106.21 ? 45  PRO C CB  1 
ATOM 2728 C CG  . PRO C 1 45  ? -9.871  47.046  128.473 1.00 106.21 ? 45  PRO C CG  1 
ATOM 2729 C CD  . PRO C 1 45  ? -9.181  46.077  129.413 1.00 106.21 ? 45  PRO C CD  1 
ATOM 2730 N N   . GLU C 1 46  ? -11.949 44.075  128.683 1.00 107.78 ? 46  GLU C N   1 
ATOM 2731 C CA  . GLU C 1 46  ? -12.678 43.173  127.754 1.00 107.78 ? 46  GLU C CA  1 
ATOM 2732 C C   . GLU C 1 46  ? -13.436 42.106  128.542 1.00 107.78 ? 46  GLU C C   1 
ATOM 2733 O O   . GLU C 1 46  ? -13.064 41.865  129.708 1.00 107.78 ? 46  GLU C O   1 
ATOM 2734 C CB  . GLU C 1 46  ? -11.719 42.510  126.763 1.00 107.78 ? 46  GLU C CB  1 
ATOM 2735 C CG  . GLU C 1 46  ? -10.764 41.509  127.393 1.00 107.78 ? 46  GLU C CG  1 
ATOM 2736 C CD  . GLU C 1 46  ? -9.447  42.089  127.876 1.00 107.78 ? 46  GLU C CD  1 
ATOM 2737 O OE1 . GLU C 1 46  ? -9.308  43.326  127.867 1.00 107.78 ? 46  GLU C OE1 1 
ATOM 2738 O OE2 . GLU C 1 46  ? -8.559  41.297  128.251 1.00 107.78 ? 46  GLU C OE2 1 
ATOM 2739 N N   . HIS C 1 47  ? -14.461 41.504  127.938 1.00 105.67 ? 47  HIS C N   1 
ATOM 2740 C CA  . HIS C 1 47  ? -15.238 40.406  128.554 1.00 105.67 ? 47  HIS C CA  1 
ATOM 2741 C C   . HIS C 1 47  ? -14.488 39.100  128.315 1.00 105.67 ? 47  HIS C C   1 
ATOM 2742 O O   . HIS C 1 47  ? -14.951 38.310  127.479 1.00 105.67 ? 47  HIS C O   1 
ATOM 2743 C CB  . HIS C 1 47  ? -16.647 40.373  127.956 1.00 105.67 ? 47  HIS C CB  1 
ATOM 2744 C CG  . HIS C 1 47  ? -17.339 41.693  127.927 1.00 105.67 ? 47  HIS C CG  1 
ATOM 2745 N ND1 . HIS C 1 47  ? -18.472 41.944  128.671 1.00 105.67 ? 47  HIS C ND1 1 
ATOM 2746 C CD2 . HIS C 1 47  ? -17.078 42.824  127.240 1.00 105.67 ? 47  HIS C CD2 1 
ATOM 2747 C CE1 . HIS C 1 47  ? -18.875 43.178  128.452 1.00 105.67 ? 47  HIS C CE1 1 
ATOM 2748 N NE2 . HIS C 1 47  ? -18.037 43.740  127.577 1.00 105.67 ? 47  HIS C NE2 1 
ATOM 2749 N N   . CYS C 1 48  ? -13.389 38.863  129.028 1.00 104.87 ? 48  CYS C N   1 
ATOM 2750 C CA  . CYS C 1 48  ? -12.585 37.661  128.838 1.00 104.87 ? 48  CYS C CA  1 
ATOM 2751 C C   . CYS C 1 48  ? -13.437 36.406  128.983 1.00 104.87 ? 48  CYS C C   1 
ATOM 2752 O O   . CYS C 1 48  ? -13.328 35.477  128.174 1.00 104.87 ? 48  CYS C O   1 
ATOM 2753 C CB  . CYS C 1 48  ? -11.434 37.645  129.841 1.00 104.87 ? 48  CYS C CB  1 
ATOM 2754 S SG  . CYS C 1 48  ? -10.246 38.986  129.617 1.00 104.87 ? 48  CYS C SG  1 
ATOM 2755 N N   . SER C 1 49  ? -14.284 36.354  130.008 1.00 102.34 ? 49  SER C N   1 
ATOM 2756 C CA  . SER C 1 49  ? -15.197 35.236  130.202 1.00 102.34 ? 49  SER C CA  1 
ATOM 2757 C C   . SER C 1 49  ? -16.312 35.680  131.139 1.00 102.34 ? 49  SER C C   1 
ATOM 2758 O O   . SER C 1 49  ? -16.147 36.652  131.886 1.00 102.34 ? 49  SER C O   1 
ATOM 2759 C CB  . SER C 1 49  ? -14.458 34.014  130.772 1.00 102.34 ? 49  SER C CB  1 
ATOM 2760 O OG  . SER C 1 49  ? -15.348 32.976  131.134 1.00 102.34 ? 49  SER C OG  1 
ATOM 2761 N N   . PRO C 1 50  ? -17.458 34.993  131.121 1.00 97.23  ? 50  PRO C N   1 
ATOM 2762 C CA  . PRO C 1 50  ? -18.464 35.193  132.181 1.00 97.23  ? 50  PRO C CA  1 
ATOM 2763 C C   . PRO C 1 50  ? -17.937 34.974  133.593 1.00 97.23  ? 50  PRO C C   1 
ATOM 2764 O O   . PRO C 1 50  ? -18.409 35.617  134.548 1.00 97.23  ? 50  PRO C O   1 
ATOM 2765 C CB  . PRO C 1 50  ? -19.560 34.179  131.816 1.00 97.23  ? 50  PRO C CB  1 
ATOM 2766 C CG  . PRO C 1 50  ? -18.906 33.194  130.916 1.00 97.23  ? 50  PRO C CG  1 
ATOM 2767 C CD  . PRO C 1 50  ? -17.891 33.979  130.148 1.00 97.23  ? 50  PRO C CD  1 
ATOM 2768 N N   . HIS C 1 51  ? -16.941 34.098  133.744 1.00 96.04  ? 51  HIS C N   1 
ATOM 2769 C CA  . HIS C 1 51  ? -16.311 33.887  135.043 1.00 96.04  ? 51  HIS C CA  1 
ATOM 2770 C C   . HIS C 1 51  ? -15.664 35.164  135.568 1.00 96.04  ? 51  HIS C C   1 
ATOM 2771 O O   . HIS C 1 51  ? -15.771 35.476  136.762 1.00 96.04  ? 51  HIS C O   1 
ATOM 2772 C CB  . HIS C 1 51  ? -15.251 32.791  134.915 1.00 96.04  ? 51  HIS C CB  1 
ATOM 2773 C CG  . HIS C 1 51  ? -15.806 31.439  134.588 1.00 96.04  ? 51  HIS C CG  1 
ATOM 2774 N ND1 . HIS C 1 51  ? -16.601 30.723  135.457 1.00 96.04  ? 51  HIS C ND1 1 
ATOM 2775 C CD2 . HIS C 1 51  ? -15.677 30.672  133.479 1.00 96.04  ? 51  HIS C CD2 1 
ATOM 2776 C CE1 . HIS C 1 51  ? -16.941 29.577  134.896 1.00 96.04  ? 51  HIS C CE1 1 
ATOM 2777 N NE2 . HIS C 1 51  ? -16.387 29.517  133.700 1.00 96.04  ? 51  HIS C NE2 1 
ATOM 2778 N N   . HIS C 1 52  ? -15.015 35.930  134.691 1.00 97.98  ? 52  HIS C N   1 
ATOM 2779 C CA  . HIS C 1 52  ? -14.399 37.177  135.128 1.00 97.98  ? 52  HIS C CA  1 
ATOM 2780 C C   . HIS C 1 52  ? -15.442 38.167  135.631 1.00 97.98  ? 52  HIS C C   1 
ATOM 2781 O O   . HIS C 1 52  ? -15.237 38.825  136.658 1.00 97.98  ? 52  HIS C O   1 
ATOM 2782 C CB  . HIS C 1 52  ? -13.590 37.791  133.985 1.00 97.98  ? 52  HIS C CB  1 
ATOM 2783 C CG  . HIS C 1 52  ? -12.408 36.972  133.570 1.00 97.98  ? 52  HIS C CG  1 
ATOM 2784 N ND1 . HIS C 1 52  ? -12.523 35.835  132.801 1.00 97.98  ? 52  HIS C ND1 1 
ATOM 2785 C CD2 . HIS C 1 52  ? -11.083 37.138  133.798 1.00 97.98  ? 52  HIS C CD2 1 
ATOM 2786 C CE1 . HIS C 1 52  ? -11.322 35.334  132.575 1.00 97.98  ? 52  HIS C CE1 1 
ATOM 2787 N NE2 . HIS C 1 52  ? -10.431 36.100  133.178 1.00 97.98  ? 52  HIS C NE2 1 
ATOM 2788 N N   . THR C 1 53  ? -16.559 38.304  134.915 1.00 95.95  ? 53  THR C N   1 
ATOM 2789 C CA  . THR C 1 53  ? -17.596 39.242  135.334 1.00 95.95  ? 53  THR C CA  1 
ATOM 2790 C C   . THR C 1 53  ? -18.249 38.830  136.651 1.00 95.95  ? 53  THR C C   1 
ATOM 2791 O O   . THR C 1 53  ? -18.494 39.678  137.526 1.00 95.95  ? 53  THR C O   1 
ATOM 2792 C CB  . THR C 1 53  ? -18.653 39.355  134.233 1.00 95.95  ? 53  THR C CB  1 
ATOM 2793 O OG1 . THR C 1 53  ? -18.061 39.905  133.050 1.00 95.95  ? 53  THR C OG1 1 
ATOM 2794 C CG2 . THR C 1 53  ? -19.809 40.239  134.672 1.00 95.95  ? 53  THR C CG2 1 
ATOM 2795 N N   . ALA C 1 54  ? -18.471 37.527  136.847 1.00 93.76  ? 54  ALA C N   1 
ATOM 2796 C CA  . ALA C 1 54  ? -18.984 37.068  138.135 1.00 93.76  ? 54  ALA C CA  1 
ATOM 2797 C C   . ALA C 1 54  ? -18.006 37.351  139.269 1.00 93.76  ? 54  ALA C C   1 
ATOM 2798 O O   . ALA C 1 54  ? -18.406 37.829  140.342 1.00 93.76  ? 54  ALA C O   1 
ATOM 2799 C CB  . ALA C 1 54  ? -19.300 35.575  138.067 1.00 93.76  ? 54  ALA C CB  1 
ATOM 2800 N N   . LEU C 1 55  ? -16.718 37.087  139.047 1.00 94.89  ? 55  LEU C N   1 
ATOM 2801 C CA  . LEU C 1 55  ? -15.731 37.396  140.074 1.00 94.89  ? 55  LEU C CA  1 
ATOM 2802 C C   . LEU C 1 55  ? -15.702 38.888  140.386 1.00 94.89  ? 55  LEU C C   1 
ATOM 2803 O O   . LEU C 1 55  ? -15.612 39.283  141.553 1.00 94.89  ? 55  LEU C O   1 
ATOM 2804 C CB  . LEU C 1 55  ? -14.353 36.908  139.629 1.00 94.89  ? 55  LEU C CB  1 
ATOM 2805 C CG  . LEU C 1 55  ? -14.137 35.392  139.690 1.00 94.89  ? 55  LEU C CG  1 
ATOM 2806 C CD1 . LEU C 1 55  ? -12.829 35.007  139.020 1.00 94.89  ? 55  LEU C CD1 1 
ATOM 2807 C CD2 . LEU C 1 55  ? -14.170 34.879  141.122 1.00 94.89  ? 55  LEU C CD2 1 
ATOM 2808 N N   . ARG C 1 56  ? -15.731 39.731  139.352 1.00 97.46  ? 56  ARG C N   1 
ATOM 2809 C CA  . ARG C 1 56  ? -15.725 41.175  139.563 1.00 97.46  ? 56  ARG C CA  1 
ATOM 2810 C C   . ARG C 1 56  ? -16.881 41.610  140.462 1.00 97.46  ? 56  ARG C C   1 
ATOM 2811 O O   . ARG C 1 56  ? -16.683 42.334  141.452 1.00 97.46  ? 56  ARG C O   1 
ATOM 2812 C CB  . ARG C 1 56  ? -15.800 41.879  138.206 1.00 97.46  ? 56  ARG C CB  1 
ATOM 2813 C CG  . ARG C 1 56  ? -14.504 41.823  137.401 1.00 97.46  ? 56  ARG C CG  1 
ATOM 2814 C CD  . ARG C 1 56  ? -14.742 42.212  135.944 1.00 97.46  ? 56  ARG C CD  1 
ATOM 2815 N NE  . ARG C 1 56  ? -13.523 42.188  135.142 1.00 97.46  ? 56  ARG C NE  1 
ATOM 2816 C CZ  . ARG C 1 56  ? -13.474 41.871  133.854 1.00 97.46  ? 56  ARG C CZ  1 
ATOM 2817 N NH1 . ARG C 1 56  ? -14.567 41.567  133.172 1.00 97.46  ? 56  ARG C NH1 1 
ATOM 2818 N NH2 . ARG C 1 56  ? -12.305 41.904  133.221 1.00 97.46  ? 56  ARG C NH2 1 
ATOM 2819 N N   . GLN C 1 57  ? -18.093 41.121  140.167 1.00 97.17  ? 57  GLN C N   1 
ATOM 2820 C CA  . GLN C 1 57  ? -19.245 41.502  140.984 1.00 97.17  ? 57  GLN C CA  1 
ATOM 2821 C C   . GLN C 1 57  ? -19.089 41.020  142.421 1.00 97.17  ? 57  GLN C C   1 
ATOM 2822 O O   . GLN C 1 57  ? -19.350 41.772  143.374 1.00 97.17  ? 57  GLN C O   1 
ATOM 2823 C CB  . GLN C 1 57  ? -20.533 40.946  140.378 1.00 97.17  ? 57  GLN C CB  1 
ATOM 2824 C CG  . GLN C 1 57  ? -20.827 41.417  138.964 1.00 97.17  ? 57  GLN C CG  1 
ATOM 2825 C CD  . GLN C 1 57  ? -20.951 42.924  138.864 1.00 97.17  ? 57  GLN C CD  1 
ATOM 2826 O OE1 . GLN C 1 57  ? -20.311 43.556  138.023 1.00 97.17  ? 57  GLN C OE1 1 
ATOM 2827 N NE2 . GLN C 1 57  ? -21.772 43.510  139.731 1.00 97.17  ? 57  GLN C NE2 1 
ATOM 2828 N N   . ALA C 1 58  ? -18.625 39.782  142.599 1.00 97.24  ? 58  ALA C N   1 
ATOM 2829 C CA  . ALA C 1 58  ? -18.550 39.226  143.946 1.00 97.24  ? 58  ALA C CA  1 
ATOM 2830 C C   . ALA C 1 58  ? -17.515 39.968  144.780 1.00 97.24  ? 58  ALA C C   1 
ATOM 2831 O O   . ALA C 1 58  ? -17.749 40.268  145.959 1.00 97.24  ? 58  ALA C O   1 
ATOM 2832 C CB  . ALA C 1 58  ? -18.222 37.736  143.875 1.00 97.24  ? 58  ALA C CB  1 
ATOM 2833 N N   . ILE C 1 59  ? -16.393 40.368  144.191 1.00 97.79  ? 59  ILE C N   1 
ATOM 2834 C CA  . ILE C 1 59  ? -15.303 41.045  144.956 1.00 97.79  ? 59  ILE C CA  1 
ATOM 2835 C C   . ILE C 1 59  ? -15.806 42.410  145.452 1.00 97.79  ? 59  ILE C C   1 
ATOM 2836 O O   . ILE C 1 59  ? -15.655 42.695  146.674 1.00 97.79  ? 59  ILE C O   1 
ATOM 2837 C CB  . ILE C 1 59  ? -14.034 41.156  144.093 1.00 97.79  ? 59  ILE C CB  1 
ATOM 2838 C CG1 . ILE C 1 59  ? -13.487 39.775  143.727 1.00 97.79  ? 59  ILE C CG1 1 
ATOM 2839 C CG2 . ILE C 1 59  ? -12.984 42.008  144.782 1.00 97.79  ? 59  ILE C CG2 1 
ATOM 2840 C CD1 . ILE C 1 59  ? -12.571 39.780  142.530 1.00 97.79  ? 59  ILE C CD1 1 
ATOM 2841 N N   . LEU C 1 60  ? -16.417 43.210  144.579 1.00 99.02  ? 60  LEU C N   1 
ATOM 2842 C CA  . LEU C 1 60  ? -16.908 44.571  144.923 1.00 99.02  ? 60  LEU C CA  1 
ATOM 2843 C C   . LEU C 1 60  ? -17.920 44.490  146.069 1.00 99.02  ? 60  LEU C C   1 
ATOM 2844 O O   . LEU C 1 60  ? -17.827 45.320  147.015 1.00 99.02  ? 60  LEU C O   1 
ATOM 2845 C CB  . LEU C 1 60  ? -17.544 45.184  143.673 1.00 99.02  ? 60  LEU C CB  1 
ATOM 2846 C CG  . LEU C 1 60  ? -16.598 45.404  142.492 1.00 99.02  ? 60  LEU C CG  1 
ATOM 2847 C CD1 . LEU C 1 60  ? -17.369 45.802  141.246 1.00 99.02  ? 60  LEU C CD1 1 
ATOM 2848 C CD2 . LEU C 1 60  ? -15.545 46.448  142.818 1.00 99.02  ? 60  LEU C CD2 1 
ATOM 2849 N N   . CYS C 1 61  ? -18.847 43.536  146.011 1.00 101.24 ? 61  CYS C N   1 
ATOM 2850 C CA  . CYS C 1 61  ? -19.894 43.357  147.050 1.00 101.24 ? 61  CYS C CA  1 
ATOM 2851 C C   . CYS C 1 61  ? -19.241 43.043  148.396 1.00 101.24 ? 61  CYS C C   1 
ATOM 2852 O O   . CYS C 1 61  ? -19.658 43.640  149.409 1.00 101.24 ? 61  CYS C O   1 
ATOM 2853 C CB  . CYS C 1 61  ? -20.846 42.234  146.669 1.00 101.24 ? 61  CYS C CB  1 
ATOM 2854 S SG  . CYS C 1 61  ? -21.862 41.668  148.055 1.00 101.24 ? 61  CYS C SG  1 
ATOM 2855 N N   . TRP C 1 62  ? -18.257 42.146  148.413 1.00 100.40 ? 62  TRP C N   1 
ATOM 2856 C CA  . TRP C 1 62  ? -17.547 41.776  149.660 1.00 100.40 ? 62  TRP C CA  1 
ATOM 2857 C C   . TRP C 1 62  ? -16.878 43.032  150.204 1.00 100.40 ? 62  TRP C C   1 
ATOM 2858 O O   . TRP C 1 62  ? -16.964 43.270  151.419 1.00 100.40 ? 62  TRP C O   1 
ATOM 2859 C CB  . TRP C 1 62  ? -16.534 40.656  149.423 1.00 100.40 ? 62  TRP C CB  1 
ATOM 2860 C CG  . TRP C 1 62  ? -15.902 40.168  150.689 1.00 100.40 ? 62  TRP C CG  1 
ATOM 2861 C CD1 . TRP C 1 62  ? -14.608 40.332  151.083 1.00 100.40 ? 62  TRP C CD1 1 
ATOM 2862 C CD2 . TRP C 1 62  ? -16.560 39.462  151.753 1.00 100.40 ? 62  TRP C CD2 1 
ATOM 2863 N NE1 . TRP C 1 62  ? -14.409 39.762  152.310 1.00 100.40 ? 62  TRP C NE1 1 
ATOM 2864 C CE2 . TRP C 1 62  ? -15.589 39.221  152.747 1.00 100.40 ? 62  TRP C CE2 1 
ATOM 2865 C CE3 . TRP C 1 62  ? -17.864 39.004  151.960 1.00 100.40 ? 62  TRP C CE3 1 
ATOM 2866 C CZ2 . TRP C 1 62  ? -15.888 38.543  153.926 1.00 100.40 ? 62  TRP C CZ2 1 
ATOM 2867 C CZ3 . TRP C 1 62  ? -18.158 38.332  153.125 1.00 100.40 ? 62  TRP C CZ3 1 
ATOM 2868 C CH2 . TRP C 1 62  ? -17.182 38.108  154.093 1.00 100.40 ? 62  TRP C CH2 1 
ATOM 2869 N N   . GLY C 1 63  ? -16.258 43.818  149.328 1.00 103.53 ? 63  GLY C N   1 
ATOM 2870 C CA  . GLY C 1 63  ? -15.633 45.084  149.747 1.00 103.53 ? 63  GLY C CA  1 
ATOM 2871 C C   . GLY C 1 63  ? -16.637 45.983  150.441 1.00 103.53 ? 63  GLY C C   1 
ATOM 2872 O O   . GLY C 1 63  ? -16.342 46.460  151.568 1.00 103.53 ? 63  GLY C O   1 
ATOM 2873 N N   . GLU C 1 64  ? -17.803 46.185  149.830 1.00 103.54 ? 64  GLU C N   1 
ATOM 2874 C CA  . GLU C 1 64  ? -18.858 47.054  150.414 1.00 103.54 ? 64  GLU C CA  1 
ATOM 2875 C C   . GLU C 1 64  ? -19.299 46.494  151.770 1.00 103.54 ? 64  GLU C C   1 
ATOM 2876 O O   . GLU C 1 64  ? -19.476 47.298  152.694 1.00 103.54 ? 64  GLU C O   1 
ATOM 2877 C CB  . GLU C 1 64  ? -20.040 47.181  149.457 1.00 103.54 ? 64  GLU C CB  1 
ATOM 2878 C CG  . GLU C 1 64  ? -19.710 47.939  148.187 1.00 103.54 ? 64  GLU C CG  1 
ATOM 2879 C CD  . GLU C 1 64  ? -19.293 49.383  148.405 1.00 103.54 ? 64  GLU C CD  1 
ATOM 2880 O OE1 . GLU C 1 64  ? -19.509 49.899  149.517 1.00 103.54 ? 64  GLU C OE1 1 
ATOM 2881 O OE2 . GLU C 1 64  ? -18.751 49.988  147.461 1.00 103.54 ? 64  GLU C OE2 1 
ATOM 2882 N N   . LEU C 1 65  ? -19.461 45.177  151.895 1.00 104.87 ? 65  LEU C N   1 
ATOM 2883 C CA  . LEU C 1 65  ? -19.885 44.540  153.173 1.00 104.87 ? 65  LEU C CA  1 
ATOM 2884 C C   . LEU C 1 65  ? -18.830 44.802  154.249 1.00 104.87 ? 65  LEU C C   1 
ATOM 2885 O O   . LEU C 1 65  ? -19.219 45.115  155.387 1.00 104.87 ? 65  LEU C O   1 
ATOM 2886 C CB  . LEU C 1 65  ? -20.082 43.038  152.958 1.00 104.87 ? 65  LEU C CB  1 
ATOM 2887 C CG  . LEU C 1 65  ? -21.333 42.641  152.183 1.00 104.87 ? 65  LEU C CG  1 
ATOM 2888 C CD1 . LEU C 1 65  ? -21.309 41.159  151.852 1.00 104.87 ? 65  LEU C CD1 1 
ATOM 2889 C CD2 . LEU C 1 65  ? -22.589 42.992  152.963 1.00 104.87 ? 65  LEU C CD2 1 
ATOM 2890 N N   . MET C 1 66  ? -17.547 44.686  153.913 1.00 107.71 ? 66  MET C N   1 
ATOM 2891 C CA  . MET C 1 66  ? -16.439 44.960  154.865 1.00 107.71 ? 66  MET C CA  1 
ATOM 2892 C C   . MET C 1 66  ? -16.504 46.425  155.291 1.00 107.71 ? 66  MET C C   1 
ATOM 2893 O O   . MET C 1 66  ? -16.302 46.708  156.496 1.00 107.71 ? 66  MET C O   1 
ATOM 2894 C CB  . MET C 1 66  ? -15.081 44.687  154.219 1.00 107.71 ? 66  MET C CB  1 
ATOM 2895 C CG  . MET C 1 66  ? -14.819 43.223  153.941 1.00 107.71 ? 66  MET C CG  1 
ATOM 2896 S SD  . MET C 1 66  ? -14.943 42.194  155.422 1.00 107.71 ? 66  MET C SD  1 
ATOM 2897 C CE  . MET C 1 66  ? -16.636 41.621  155.274 1.00 107.71 ? 66  MET C CE  1 
ATOM 2898 N N   . THR C 1 67  ? -16.760 47.332  154.348 1.00 107.41 ? 67  THR C N   1 
ATOM 2899 C CA  . THR C 1 67  ? -16.886 48.776  154.656 1.00 107.41 ? 67  THR C CA  1 
ATOM 2900 C C   . THR C 1 67  ? -18.021 48.953  155.657 1.00 107.41 ? 67  THR C C   1 
ATOM 2901 O O   . THR C 1 67  ? -17.822 49.687  156.634 1.00 107.41 ? 67  THR C O   1 
ATOM 2902 C CB  . THR C 1 67  ? -17.144 49.609  153.400 1.00 107.41 ? 67  THR C CB  1 
ATOM 2903 O OG1 . THR C 1 67  ? -16.017 49.472  152.536 1.00 107.41 ? 67  THR C OG1 1 
ATOM 2904 C CG2 . THR C 1 67  ? -17.380 51.069  153.709 1.00 107.41 ? 67  THR C CG2 1 
ATOM 2905 N N   . LEU C 1 68  ? -19.157 48.295  155.426 1.00 110.73 ? 68  LEU C N   1 
ATOM 2906 C CA  . LEU C 1 68  ? -20.328 48.375  156.335 1.00 110.73 ? 68  LEU C CA  1 
ATOM 2907 C C   . LEU C 1 68  ? -19.906 47.893  157.713 1.00 110.73 ? 68  LEU C C   1 
ATOM 2908 O O   . LEU C 1 68  ? -20.267 48.549  158.673 1.00 110.73 ? 68  LEU C O   1 
ATOM 2909 C CB  . LEU C 1 68  ? -21.465 47.502  155.803 1.00 110.73 ? 68  LEU C CB  1 
ATOM 2910 C CG  . LEU C 1 68  ? -22.510 47.088  156.837 1.00 110.73 ? 68  LEU C CG  1 
ATOM 2911 C CD1 . LEU C 1 68  ? -23.194 48.302  157.439 1.00 110.73 ? 68  LEU C CD1 1 
ATOM 2912 C CD2 . LEU C 1 68  ? -23.538 46.160  156.216 1.00 110.73 ? 68  LEU C CD2 1 
ATOM 2913 N N   . ALA C 1 69  ? -19.191 46.777  157.796 1.00 112.43 ? 69  ALA C N   1 
ATOM 2914 C CA  . ALA C 1 69  ? -18.721 46.211  159.079 1.00 112.43 ? 69  ALA C CA  1 
ATOM 2915 C C   . ALA C 1 69  ? -17.870 47.249  159.804 1.00 112.43 ? 69  ALA C C   1 
ATOM 2916 O O   . ALA C 1 69  ? -18.100 47.438  160.990 1.00 112.43 ? 69  ALA C O   1 
ATOM 2917 C CB  . ALA C 1 69  ? -17.938 44.953  158.832 1.00 112.43 ? 69  ALA C CB  1 
ATOM 2918 N N   . THR C 1 70  ? -16.937 47.900  159.110 1.00 115.92 ? 70  THR C N   1 
ATOM 2919 C CA  . THR C 1 70  ? -16.049 48.928  159.715 1.00 115.92 ? 70  THR C CA  1 
ATOM 2920 C C   . THR C 1 70  ? -16.881 50.118  160.194 1.00 115.92 ? 70  THR C C   1 
ATOM 2921 O O   . THR C 1 70  ? -16.556 50.641  161.263 1.00 115.92 ? 70  THR C O   1 
ATOM 2922 C CB  . THR C 1 70  ? -14.976 49.390  158.726 1.00 115.92 ? 70  THR C CB  1 
ATOM 2923 O OG1 . THR C 1 70  ? -14.142 48.271  158.431 1.00 115.92 ? 70  THR C OG1 1 
ATOM 2924 C CG2 . THR C 1 70  ? -14.140 50.532  159.259 1.00 115.92 ? 70  THR C CG2 1 
ATOM 2925 N N   . TRP C 1 71  ? -17.895 50.535  159.431 1.00 119.74 ? 71  TRP C N   1 
ATOM 2926 C CA  . TRP C 1 71  ? -18.775 51.680  159.791 1.00 119.74 ? 71  TRP C CA  1 
ATOM 2927 C C   . TRP C 1 71  ? -19.601 51.309  161.012 1.00 119.74 ? 71  TRP C C   1 
ATOM 2928 O O   . TRP C 1 71  ? -19.953 52.214  161.768 1.00 119.74 ? 71  TRP C O   1 
ATOM 2929 C CB  . TRP C 1 71  ? -19.690 52.065  158.626 1.00 119.74 ? 71  TRP C CB  1 
ATOM 2930 C CG  . TRP C 1 71  ? -20.737 53.075  158.978 1.00 119.74 ? 71  TRP C CG  1 
ATOM 2931 C CD1 . TRP C 1 71  ? -20.722 54.409  158.691 1.00 119.74 ? 71  TRP C CD1 1 
ATOM 2932 C CD2 . TRP C 1 71  ? -21.966 52.834  159.687 1.00 119.74 ? 71  TRP C CD2 1 
ATOM 2933 N NE1 . TRP C 1 71  ? -21.853 55.012  159.172 1.00 119.74 ? 71  TRP C NE1 1 
ATOM 2934 C CE2 . TRP C 1 71  ? -22.634 54.072  159.787 1.00 119.74 ? 71  TRP C CE2 1 
ATOM 2935 C CE3 . TRP C 1 71  ? -22.563 51.700  160.246 1.00 119.74 ? 71  TRP C CE3 1 
ATOM 2936 C CZ2 . TRP C 1 71  ? -23.867 54.203  160.423 1.00 119.74 ? 71  TRP C CZ2 1 
ATOM 2937 C CZ3 . TRP C 1 71  ? -23.781 51.830  160.874 1.00 119.74 ? 71  TRP C CZ3 1 
ATOM 2938 C CH2 . TRP C 1 71  ? -24.422 53.066  160.960 1.00 119.74 ? 71  TRP C CH2 1 
ATOM 2939 N N   . VAL C 1 72  ? -19.954 50.035  161.149 1.00 123.50 ? 72  VAL C N   1 
ATOM 2940 C CA  . VAL C 1 72  ? -20.755 49.555  162.304 1.00 123.50 ? 72  VAL C CA  1 
ATOM 2941 C C   . VAL C 1 72  ? -19.784 49.508  163.467 1.00 123.50 ? 72  VAL C C   1 
ATOM 2942 O O   . VAL C 1 72  ? -20.218 49.737  164.616 1.00 123.50 ? 72  VAL C O   1 
ATOM 2943 C CB  . VAL C 1 72  ? -21.406 48.182  162.057 1.00 123.50 ? 72  VAL C CB  1 
ATOM 2944 C CG1 . VAL C 1 72  ? -21.891 47.552  163.350 1.00 123.50 ? 72  VAL C CG1 1 
ATOM 2945 C CG2 . VAL C 1 72  ? -22.536 48.273  161.045 1.00 123.50 ? 72  VAL C CG2 1 
ATOM 2946 N N   . GLY C 1 73  ? -18.506 49.245  163.184 1.00 125.33 ? 73  GLY C N   1 
ATOM 2947 C CA  . GLY C 1 73  ? -17.555 49.273  164.281 1.00 125.33 ? 73  GLY C CA  1 
ATOM 2948 C C   . GLY C 1 73  ? -17.273 50.657  164.828 1.00 125.33 ? 73  GLY C C   1 
ATOM 2949 O O   . GLY C 1 73  ? -17.045 50.817  166.029 1.00 125.33 ? 73  GLY C O   1 
ATOM 2950 N N   . VAL C 1 74  ? -17.285 51.676  163.967 1.00 128.71 ? 74  VAL C N   1 
ATOM 2951 C CA  . VAL C 1 74  ? -17.138 53.041  164.476 1.00 128.71 ? 74  VAL C CA  1 
ATOM 2952 C C   . VAL C 1 74  ? -18.429 53.593  165.081 1.00 128.71 ? 74  VAL C C   1 
ATOM 2953 O O   . VAL C 1 74  ? -18.414 54.164  166.177 1.00 128.71 ? 74  VAL C O   1 
ATOM 2954 C CB  . VAL C 1 74  ? -16.667 53.998  163.366 1.00 30.00  ? 74  VAL C CB  1 
ATOM 2955 C CG1 . VAL C 1 74  ? -16.618 55.428  163.880 1.00 30.00  ? 74  VAL C CG1 1 
ATOM 2956 C CG2 . VAL C 1 74  ? -15.308 53.568  162.833 1.00 30.00  ? 74  VAL C CG2 1 
ATOM 2957 N N   . ASN C 1 75  ? -19.550 53.439  164.377 1.00 129.25 ? 75  ASN C N   1 
ATOM 2958 C CA  . ASN C 1 75  ? -20.802 54.080  164.778 1.00 129.25 ? 75  ASN C CA  1 
ATOM 2959 C C   . ASN C 1 75  ? -21.459 53.397  165.972 1.00 129.25 ? 75  ASN C C   1 
ATOM 2960 O O   . ASN C 1 75  ? -21.846 54.059  166.941 1.00 129.25 ? 75  ASN C O   1 
ATOM 2961 C CB  . ASN C 1 75  ? -21.761 54.128  163.591 1.00 129.25 ? 75  ASN C CB  1 
ATOM 2962 C CG  . ASN C 1 75  ? -21.332 55.133  162.547 1.00 129.25 ? 75  ASN C CG  1 
ATOM 2963 O OD1 . ASN C 1 75  ? -20.585 54.810  161.626 1.00 129.25 ? 75  ASN C OD1 1 
ATOM 2964 N ND2 . ASN C 1 75  ? -21.796 56.368  162.694 1.00 129.25 ? 75  ASN C ND2 1 
ATOM 2965 N N   . LEU C 1 76  ? -21.607 52.076  165.921 1.00 136.25 ? 76  LEU C N   1 
ATOM 2966 C CA  . LEU C 1 76  ? -22.502 51.390  166.844 1.00 136.25 ? 76  LEU C CA  1 
ATOM 2967 C C   . LEU C 1 76  ? -21.942 51.356  168.262 1.00 136.25 ? 76  LEU C C   1 
ATOM 2968 O O   . LEU C 1 76  ? -20.816 50.911  168.501 1.00 136.25 ? 76  LEU C O   1 
ATOM 2969 C CB  . LEU C 1 76  ? -22.779 49.979  166.332 1.00 136.25 ? 76  LEU C CB  1 
ATOM 2970 C CG  . LEU C 1 76  ? -23.741 49.119  167.148 1.00 136.25 ? 76  LEU C CG  1 
ATOM 2971 C CD1 . LEU C 1 76  ? -25.086 49.783  167.336 1.00 136.25 ? 76  LEU C CD1 1 
ATOM 2972 C CD2 . LEU C 1 76  ? -23.918 47.790  166.436 1.00 136.25 ? 76  LEU C CD2 1 
ATOM 2973 N N   . GLU C 1 77  ? -22.772 51.820  169.199 1.00 141.93 ? 77  GLU C N   1 
ATOM 2974 C CA  . GLU C 1 77  ? -22.381 52.283  170.523 1.00 141.93 ? 77  GLU C CA  1 
ATOM 2975 C C   . GLU C 1 77  ? -22.349 51.206  171.602 1.00 141.93 ? 77  GLU C C   1 
ATOM 2976 O O   . GLU C 1 77  ? -21.923 51.508  172.722 1.00 141.93 ? 77  GLU C O   1 
ATOM 2977 C CB  . GLU C 1 77  ? -23.340 53.385  170.985 1.00 141.93 ? 77  GLU C CB  1 
ATOM 2978 C CG  . GLU C 1 77  ? -23.275 54.662  170.167 1.00 141.93 ? 77  GLU C CG  1 
ATOM 2979 C CD  . GLU C 1 77  ? -21.954 55.386  170.315 1.00 141.93 ? 77  GLU C CD  1 
ATOM 2980 O OE1 . GLU C 1 77  ? -21.346 55.297  171.402 1.00 141.93 ? 77  GLU C OE1 1 
ATOM 2981 O OE2 . GLU C 1 77  ? -21.524 56.044  169.345 1.00 141.93 ? 77  GLU C OE2 1 
ATOM 2982 N N   . ASP C 1 78  ? -22.780 49.977  171.327 1.00 141.59 ? 78  ASP C N   1 
ATOM 2983 C CA  . ASP C 1 78  ? -22.697 48.964  172.367 1.00 141.59 ? 78  ASP C CA  1 
ATOM 2984 C C   . ASP C 1 78  ? -22.036 47.683  171.880 1.00 141.59 ? 78  ASP C C   1 
ATOM 2985 O O   . ASP C 1 78  ? -22.175 47.298  170.714 1.00 141.59 ? 78  ASP C O   1 
ATOM 2986 C CB  . ASP C 1 78  ? -24.099 48.642  172.912 1.00 141.59 ? 78  ASP C CB  1 
ATOM 2987 C CG  . ASP C 1 78  ? -24.681 49.767  173.744 1.00 141.59 ? 78  ASP C CG  1 
ATOM 2988 O OD1 . ASP C 1 78  ? -23.916 50.670  174.143 1.00 141.59 ? 78  ASP C OD1 1 
ATOM 2989 O OD2 . ASP C 1 78  ? -25.902 49.742  174.008 1.00 141.59 ? 78  ASP C OD2 1 
ATOM 2990 N N   . PRO C 1 79  ? -21.316 46.997  172.775 1.00 138.25 ? 79  PRO C N   1 
ATOM 2991 C CA  . PRO C 1 79  ? -20.483 45.865  172.337 1.00 138.25 ? 79  PRO C CA  1 
ATOM 2992 C C   . PRO C 1 79  ? -21.255 44.646  171.876 1.00 138.25 ? 79  PRO C C   1 
ATOM 2993 O O   . PRO C 1 79  ? -20.839 43.989  170.914 1.00 138.25 ? 79  PRO C O   1 
ATOM 2994 C CB  . PRO C 1 79  ? -19.643 45.554  173.589 1.00 138.25 ? 79  PRO C CB  1 
ATOM 2995 C CG  . PRO C 1 79  ? -20.430 46.101  174.731 1.00 138.25 ? 79  PRO C CG  1 
ATOM 2996 C CD  . PRO C 1 79  ? -21.099 47.323  174.195 1.00 138.25 ? 79  PRO C CD  1 
ATOM 2997 N N   . ALA C 1 80  ? -22.386 44.336  172.504 1.00 135.75 ? 80  ALA C N   1 
ATOM 2998 C CA  . ALA C 1 80  ? -23.117 43.138  172.113 1.00 135.75 ? 80  ALA C CA  1 
ATOM 2999 C C   . ALA C 1 80  ? -23.656 43.242  170.693 1.00 135.75 ? 80  ALA C C   1 
ATOM 3000 O O   . ALA C 1 80  ? -23.516 42.308  169.899 1.00 135.75 ? 80  ALA C O   1 
ATOM 3001 C CB  . ALA C 1 80  ? -24.253 42.885  173.102 1.00 135.75 ? 80  ALA C CB  1 
ATOM 3002 N N   . SER C 1 81  ? -24.290 44.363  170.357 1.00 137.16 ? 81  SER C N   1 
ATOM 3003 C CA  . SER C 1 81  ? -24.837 44.537  169.015 1.00 137.16 ? 81  SER C CA  1 
ATOM 3004 C C   . SER C 1 81  ? -23.757 44.487  167.932 1.00 137.16 ? 81  SER C C   1 
ATOM 3005 O O   . SER C 1 81  ? -23.895 43.758  166.937 1.00 137.16 ? 81  SER C O   1 
ATOM 3006 C CB  . SER C 1 81  ? -25.615 45.849  168.955 1.00 137.16 ? 81  SER C CB  1 
ATOM 3007 O OG  . SER C 1 81  ? -26.710 45.819  169.854 1.00 137.16 ? 81  SER C OG  1 
ATOM 3008 N N   . ARG C 1 82  ? -22.650 45.217  168.123 1.00 136.98 ? 82  ARG C N   1 
ATOM 3009 C CA  . ARG C 1 82  ? -21.596 45.174  167.111 1.00 136.98 ? 82  ARG C CA  1 
ATOM 3010 C C   . ARG C 1 82  ? -20.985 43.784  167.006 1.00 136.98 ? 82  ARG C C   1 
ATOM 3011 O O   . ARG C 1 82  ? -20.717 43.300  165.898 1.00 136.98 ? 82  ARG C O   1 
ATOM 3012 C CB  . ARG C 1 82  ? -20.490 46.208  167.386 1.00 136.98 ? 82  ARG C CB  1 
ATOM 3013 C CG  . ARG C 1 82  ? -19.618 46.001  168.639 1.00 136.98 ? 82  ARG C CG  1 
ATOM 3014 C CD  . ARG C 1 82  ? -18.504 47.075  168.707 1.00 136.98 ? 82  ARG C CD  1 
ATOM 3015 N NE  . ARG C 1 82  ? -18.930 48.443  168.987 1.00 136.98 ? 82  ARG C NE  1 
ATOM 3016 C CZ  . ARG C 1 82  ? -19.047 48.969  170.202 1.00 136.98 ? 82  ARG C CZ  1 
ATOM 3017 N NH1 . ARG C 1 82  ? -18.813 48.259  171.293 1.00 136.98 ? 82  ARG C NH1 1 
ATOM 3018 N NH2 . ARG C 1 82  ? -19.395 50.249  170.326 1.00 136.98 ? 82  ARG C NH2 1 
ATOM 3019 N N   . ASP C 1 83  ? -20.806 43.102  168.136 1.00 135.10 ? 83  ASP C N   1 
ATOM 3020 C CA  . ASP C 1 83  ? -20.234 41.761  168.094 1.00 135.10 ? 83  ASP C CA  1 
ATOM 3021 C C   . ASP C 1 83  ? -21.154 40.802  167.353 1.00 135.10 ? 83  ASP C C   1 
ATOM 3022 O O   . ASP C 1 83  ? -20.719 40.064  166.462 1.00 135.10 ? 83  ASP C O   1 
ATOM 3023 C CB  . ASP C 1 83  ? -19.976 41.263  169.514 1.00 135.10 ? 83  ASP C CB  1 
ATOM 3024 C CG  . ASP C 1 83  ? -18.861 42.019  170.204 1.00 135.10 ? 83  ASP C CG  1 
ATOM 3025 O OD1 . ASP C 1 83  ? -17.947 42.504  169.504 1.00 135.10 ? 83  ASP C OD1 1 
ATOM 3026 O OD2 . ASP C 1 83  ? -18.896 42.126  171.448 1.00 135.10 ? 83  ASP C OD2 1 
ATOM 3027 N N   . LEU C 1 84  ? -22.433 40.792  167.725 1.00 128.17 ? 84  LEU C N   1 
ATOM 3028 C CA  . LEU C 1 84  ? -23.413 39.925  167.083 1.00 128.17 ? 84  LEU C CA  1 
ATOM 3029 C C   . LEU C 1 84  ? -23.440 40.123  165.574 1.00 128.17 ? 84  LEU C C   1 
ATOM 3030 O O   . LEU C 1 84  ? -23.406 39.154  164.805 1.00 128.17 ? 84  LEU C O   1 
ATOM 3031 C CB  . LEU C 1 84  ? -24.801 40.180  167.677 1.00 128.17 ? 84  LEU C CB  1 
ATOM 3032 C CG  . LEU C 1 84  ? -25.072 39.610  169.070 1.00 128.17 ? 84  LEU C CG  1 
ATOM 3033 C CD1 . LEU C 1 84  ? -26.357 40.183  169.640 1.00 128.17 ? 84  LEU C CD1 1 
ATOM 3034 C CD2 . LEU C 1 84  ? -25.144 38.093  169.028 1.00 128.17 ? 84  LEU C CD2 1 
ATOM 3035 N N   . VAL C 1 85  ? -23.473 41.380  165.127 1.00 124.54 ? 85  VAL C N   1 
ATOM 3036 C CA  . VAL C 1 85  ? -23.542 41.628  163.690 1.00 124.54 ? 85  VAL C CA  1 
ATOM 3037 C C   . VAL C 1 85  ? -22.240 41.250  162.987 1.00 124.54 ? 85  VAL C C   1 
ATOM 3038 O O   . VAL C 1 85  ? -22.265 40.707  161.873 1.00 124.54 ? 85  VAL C O   1 
ATOM 3039 C CB  . VAL C 1 85  ? -23.909 43.103  163.440 1.00 124.54 ? 85  VAL C CB  1 
ATOM 3040 C CG1 . VAL C 1 85  ? -23.906 43.431  161.947 1.00 124.54 ? 85  VAL C CG1 1 
ATOM 3041 C CG2 . VAL C 1 85  ? -25.266 43.422  164.048 1.00 124.54 ? 85  VAL C CG2 1 
ATOM 3042 N N   . VAL C 1 86  ? -21.088 41.496  163.614 1.00 123.23 ? 86  VAL C N   1 
ATOM 3043 C CA  . VAL C 1 86  ? -19.834 41.104  162.975 1.00 123.23 ? 86  VAL C CA  1 
ATOM 3044 C C   . VAL C 1 86  ? -19.729 39.585  162.846 1.00 123.23 ? 86  VAL C C   1 
ATOM 3045 O O   . VAL C 1 86  ? -19.344 39.067  161.787 1.00 123.23 ? 86  VAL C O   1 
ATOM 3046 C CB  . VAL C 1 86  ? -18.643 41.695  163.751 1.00 123.23 ? 86  VAL C CB  1 
ATOM 3047 C CG1 . VAL C 1 86  ? -17.328 41.162  163.212 1.00 123.23 ? 86  VAL C CG1 1 
ATOM 3048 C CG2 . VAL C 1 86  ? -18.658 43.208  163.658 1.00 123.23 ? 86  VAL C CG2 1 
ATOM 3049 N N   . SER C 1 87  ? -20.130 38.844  163.883 1.00 124.64 ? 87  SER C N   1 
ATOM 3050 C CA  . SER C 1 87  ? -20.166 37.386  163.768 1.00 124.64 ? 87  SER C CA  1 
ATOM 3051 C C   . SER C 1 87  ? -21.100 36.935  162.652 1.00 124.64 ? 87  SER C C   1 
ATOM 3052 O O   . SER C 1 87  ? -20.730 36.096  161.819 1.00 124.64 ? 87  SER C O   1 
ATOM 3053 C CB  . SER C 1 87  ? -20.597 36.755  165.094 1.00 30.00  ? 87  SER C CB  1 
ATOM 3054 O OG  . SER C 1 87  ? -21.923 37.126  165.428 1.00 30.00  ? 87  SER C OG  1 
ATOM 3055 N N   . TYR C 1 88  ? -22.330 37.448  162.644 1.00 117.35 ? 88  TYR C N   1 
ATOM 3056 C CA  . TYR C 1 88  ? -23.295 37.010  161.641 1.00 117.35 ? 88  TYR C CA  1 
ATOM 3057 C C   . TYR C 1 88  ? -22.759 37.233  160.234 1.00 117.35 ? 88  TYR C C   1 
ATOM 3058 O O   . TYR C 1 88  ? -22.748 36.313  159.398 1.00 117.35 ? 88  TYR C O   1 
ATOM 3059 C CB  . TYR C 1 88  ? -24.615 37.751  161.832 1.00 117.35 ? 88  TYR C CB  1 
ATOM 3060 C CG  . TYR C 1 88  ? -25.659 37.396  160.804 1.00 117.35 ? 88  TYR C CG  1 
ATOM 3061 C CD1 . TYR C 1 88  ? -26.534 36.344  161.009 1.00 117.35 ? 88  TYR C CD1 1 
ATOM 3062 C CD2 . TYR C 1 88  ? -25.772 38.124  159.627 1.00 117.35 ? 88  TYR C CD2 1 
ATOM 3063 C CE1 . TYR C 1 88  ? -27.498 36.027  160.079 1.00 117.35 ? 88  TYR C CE1 1 
ATOM 3064 C CE2 . TYR C 1 88  ? -26.735 37.818  158.691 1.00 117.35 ? 88  TYR C CE2 1 
ATOM 3065 C CZ  . TYR C 1 88  ? -27.593 36.765  158.920 1.00 117.35 ? 88  TYR C CZ  1 
ATOM 3066 O OH  . TYR C 1 88  ? -28.532 36.431  157.973 1.00 117.35 ? 88  TYR C OH  1 
ATOM 3067 N N   . VAL C 1 89  ? -22.275 38.449  159.965 1.00 115.31 ? 89  VAL C N   1 
ATOM 3068 C CA  . VAL C 1 89  ? -21.805 38.784  158.625 1.00 115.31 ? 89  VAL C CA  1 
ATOM 3069 C C   . VAL C 1 89  ? -20.637 37.891  158.235 1.00 115.31 ? 89  VAL C C   1 
ATOM 3070 O O   . VAL C 1 89  ? -20.684 37.190  157.211 1.00 115.31 ? 89  VAL C O   1 
ATOM 3071 C CB  . VAL C 1 89  ? -21.420 40.272  158.555 1.00 115.31 ? 89  VAL C CB  1 
ATOM 3072 C CG1 . VAL C 1 89  ? -20.681 40.585  157.251 1.00 115.31 ? 89  VAL C CG1 1 
ATOM 3073 C CG2 . VAL C 1 89  ? -22.654 41.150  158.701 1.00 115.31 ? 89  VAL C CG2 1 
ATOM 3074 N N   . ASN C 1 90  ? -19.636 37.794  159.114 1.00 115.91 ? 90  ASN C N   1 
ATOM 3075 C CA  . ASN C 1 90  ? -18.448 37.019  158.788 1.00 115.91 ? 90  ASN C CA  1 
ATOM 3076 C C   . ASN C 1 90  ? -18.799 35.572  158.492 1.00 115.91 ? 90  ASN C C   1 
ATOM 3077 O O   . ASN C 1 90  ? -18.523 35.082  157.396 1.00 115.91 ? 90  ASN C O   1 
ATOM 3078 C CB  . ASN C 1 90  ? -17.432 37.098  159.927 1.00 115.91 ? 90  ASN C CB  1 
ATOM 3079 C CG  . ASN C 1 90  ? -16.630 38.385  159.909 1.00 115.91 ? 90  ASN C CG  1 
ATOM 3080 O OD1 . ASN C 1 90  ? -15.664 38.517  159.159 1.00 115.91 ? 90  ASN C OD1 1 
ATOM 3081 N ND2 . ASN C 1 90  ? -17.031 39.343  160.732 1.00 115.91 ? 90  ASN C ND2 1 
ATOM 3082 N N   . THR C 1 91  ? -19.594 34.941  159.349 1.00 114.17 ? 91  THR C N   1 
ATOM 3083 C CA  . THR C 1 91  ? -19.814 33.512  159.171 1.00 114.17 ? 91  THR C CA  1 
ATOM 3084 C C   . THR C 1 91  ? -20.713 33.216  157.971 1.00 114.17 ? 91  THR C C   1 
ATOM 3085 O O   . THR C 1 91  ? -20.301 32.485  157.057 1.00 114.17 ? 91  THR C O   1 
ATOM 3086 C CB  . THR C 1 91  ? -20.380 32.907  160.461 1.00 114.17 ? 91  THR C CB  1 
ATOM 3087 O OG1 . THR C 1 91  ? -20.281 31.478  160.406 1.00 114.17 ? 91  THR C OG1 1 
ATOM 3088 C CG2 . THR C 1 91  ? -21.832 33.306  160.693 1.00 114.17 ? 91  THR C CG2 1 
ATOM 3089 N N   . ASN C 1 92  ? -21.876 33.862  157.866 1.00 112.39 ? 92  ASN C N   1 
ATOM 3090 C CA  . ASN C 1 92  ? -22.782 33.461  156.791 1.00 112.39 ? 92  ASN C CA  1 
ATOM 3091 C C   . ASN C 1 92  ? -22.283 33.928  155.425 1.00 112.39 ? 92  ASN C C   1 
ATOM 3092 O O   . ASN C 1 92  ? -22.159 33.118  154.487 1.00 112.39 ? 92  ASN C O   1 
ATOM 3093 C CB  . ASN C 1 92  ? -24.182 33.997  157.075 1.00 112.39 ? 92  ASN C CB  1 
ATOM 3094 C CG  . ASN C 1 92  ? -24.746 33.474  158.379 1.00 112.39 ? 92  ASN C CG  1 
ATOM 3095 O OD1 . ASN C 1 92  ? -25.126 32.308  158.479 1.00 112.39 ? 92  ASN C OD1 1 
ATOM 3096 N ND2 . ASN C 1 92  ? -24.795 34.333  159.388 1.00 112.39 ? 92  ASN C ND2 1 
ATOM 3097 N N   . MET C 1 93  ? -21.941 35.211  155.286 1.00 109.61 ? 93  MET C N   1 
ATOM 3098 C CA  . MET C 1 93  ? -21.526 35.635  153.958 1.00 109.61 ? 93  MET C CA  1 
ATOM 3099 C C   . MET C 1 93  ? -20.144 35.099  153.610 1.00 109.61 ? 93  MET C C   1 
ATOM 3100 O O   . MET C 1 93  ? -19.881 34.835  152.432 1.00 109.61 ? 93  MET C O   1 
ATOM 3101 C CB  . MET C 1 93  ? -21.633 37.153  153.781 1.00 109.61 ? 93  MET C CB  1 
ATOM 3102 C CG  . MET C 1 93  ? -23.089 37.615  153.533 1.00 109.61 ? 93  MET C CG  1 
ATOM 3103 S SD  . MET C 1 93  ? -24.307 37.630  154.861 1.00 109.61 ? 93  MET C SD  1 
ATOM 3104 C CE  . MET C 1 93  ? -23.814 39.091  155.756 1.00 109.61 ? 93  MET C CE  1 
ATOM 3105 N N   . GLY C 1 94  ? -19.236 34.950  154.579 1.00 105.90 ? 94  GLY C N   1 
ATOM 3106 C CA  . GLY C 1 94  ? -17.989 34.277  154.284 1.00 105.90 ? 94  GLY C CA  1 
ATOM 3107 C C   . GLY C 1 94  ? -18.191 32.884  153.720 1.00 105.90 ? 94  GLY C C   1 
ATOM 3108 O O   . GLY C 1 94  ? -17.551 32.514  152.742 1.00 105.90 ? 94  GLY C O   1 
ATOM 3109 N N   . LEU C 1 95  ? -19.066 32.078  154.335 1.00 99.77  ? 95  LEU C N   1 
ATOM 3110 C CA  . LEU C 1 95  ? -19.301 30.744  153.779 1.00 99.77  ? 95  LEU C CA  1 
ATOM 3111 C C   . LEU C 1 95  ? -19.848 30.793  152.351 1.00 99.77  ? 95  LEU C C   1 
ATOM 3112 O O   . LEU C 1 95  ? -19.362 30.074  151.460 1.00 99.77  ? 95  LEU C O   1 
ATOM 3113 C CB  . LEU C 1 95  ? -20.267 29.973  154.682 1.00 99.77  ? 95  LEU C CB  1 
ATOM 3114 C CG  . LEU C 1 95  ? -20.682 28.574  154.216 1.00 99.77  ? 95  LEU C CG  1 
ATOM 3115 C CD1 . LEU C 1 95  ? -19.480 27.656  154.074 1.00 99.77  ? 95  LEU C CD1 1 
ATOM 3116 C CD2 . LEU C 1 95  ? -21.697 27.979  155.176 1.00 99.77  ? 95  LEU C CD2 1 
ATOM 3117 N N   . LYS C 1 96  ? -20.814 31.680  152.096 1.00 97.71  ? 96  LYS C N   1 
ATOM 3118 C CA  . LYS C 1 96  ? -21.363 31.795  150.743 1.00 97.71  ? 96  LYS C CA  1 
ATOM 3119 C C   . LYS C 1 96  ? -20.308 32.214  149.715 1.00 97.71  ? 96  LYS C C   1 
ATOM 3120 O O   . LYS C 1 96  ? -20.144 31.570  148.665 1.00 97.71  ? 96  LYS C O   1 
ATOM 3121 C CB  . LYS C 1 96  ? -22.544 32.765  150.740 1.00 97.71  ? 96  LYS C CB  1 
ATOM 3122 C CG  . LYS C 1 96  ? -23.748 32.255  151.523 1.00 97.71  ? 96  LYS C CG  1 
ATOM 3123 C CD  . LYS C 1 96  ? -24.936 33.193  151.402 1.00 97.71  ? 96  LYS C CD  1 
ATOM 3124 C CE  . LYS C 1 96  ? -26.105 32.737  152.263 1.00 97.71  ? 96  LYS C CE  1 
ATOM 3125 N NZ  . LYS C 1 96  ? -26.729 31.485  151.753 1.00 97.71  ? 96  LYS C NZ  1 
ATOM 3126 N N   . PHE C 1 97  ? -19.588 33.285  150.045 1.00 95.83  ? 97  PHE C N   1 
ATOM 3127 C CA  . PHE C 1 97  ? -18.515 33.796  149.162 1.00 95.83  ? 97  PHE C CA  1 
ATOM 3128 C C   . PHE C 1 97  ? -17.481 32.690  148.952 1.00 95.83  ? 97  PHE C C   1 
ATOM 3129 O O   . PHE C 1 97  ? -17.063 32.477  147.808 1.00 95.83  ? 97  PHE C O   1 
ATOM 3130 C CB  . PHE C 1 97  ? -17.924 35.040  149.830 1.00 30.00  ? 97  PHE C CB  1 
ATOM 3131 C CG  . PHE C 1 97  ? -17.067 35.937  148.975 1.00 30.00  ? 97  PHE C CG  1 
ATOM 3132 C CD1 . PHE C 1 97  ? -17.433 36.249  147.678 1.00 30.00  ? 97  PHE C CD1 1 
ATOM 3133 C CD2 . PHE C 1 97  ? -15.915 36.507  149.490 1.00 30.00  ? 97  PHE C CD2 1 
ATOM 3134 C CE1 . PHE C 1 97  ? -16.646 37.086  146.904 1.00 30.00  ? 97  PHE C CE1 1 
ATOM 3135 C CE2 . PHE C 1 97  ? -15.130 37.346  148.716 1.00 30.00  ? 97  PHE C CE2 1 
ATOM 3136 C CZ  . PHE C 1 97  ? -15.499 37.635  147.425 1.00 30.00  ? 97  PHE C CZ  1 
ATOM 3137 N N   . ARG C 1 98  ? -17.091 32.003  150.023 1.00 96.93  ? 98  ARG C N   1 
ATOM 3138 C CA  . ARG C 1 98  ? -16.085 30.955  149.936 1.00 96.93  ? 98  ARG C CA  1 
ATOM 3139 C C   . ARG C 1 98  ? -16.476 29.912  148.902 1.00 96.93  ? 98  ARG C C   1 
ATOM 3140 O O   . ARG C 1 98  ? -15.675 29.553  148.028 1.00 96.93  ? 98  ARG C O   1 
ATOM 3141 C CB  . ARG C 1 98  ? -15.900 30.306  151.308 1.00 96.93  ? 98  ARG C CB  1 
ATOM 3142 C CG  . ARG C 1 98  ? -15.023 31.098  152.251 1.00 96.93  ? 98  ARG C CG  1 
ATOM 3143 C CD  . ARG C 1 98  ? -15.139 30.601  153.683 1.00 96.93  ? 98  ARG C CD  1 
ATOM 3144 N NE  . ARG C 1 98  ? -14.702 29.219  153.832 1.00 96.93  ? 98  ARG C NE  1 
ATOM 3145 C CZ  . ARG C 1 98  ? -15.278 28.325  154.627 1.00 96.93  ? 98  ARG C CZ  1 
ATOM 3146 N NH1 . ARG C 1 98  ? -16.255 28.657  155.454 1.00 96.93  ? 98  ARG C NH1 1 
ATOM 3147 N NH2 . ARG C 1 98  ? -14.838 27.070  154.615 1.00 96.93  ? 98  ARG C NH2 1 
ATOM 3148 N N   . GLN C 1 99  ? -17.736 29.473  148.934 1.00 93.98  ? 99  GLN C N   1 
ATOM 3149 C CA  . GLN C 1 99  ? -18.185 28.522  147.919 1.00 93.98  ? 99  GLN C CA  1 
ATOM 3150 C C   . GLN C 1 99  ? -18.119 29.108  146.513 1.00 93.98  ? 99  GLN C C   1 
ATOM 3151 O O   . GLN C 1 99  ? -17.604 28.464  145.584 1.00 93.98  ? 99  GLN C O   1 
ATOM 3152 C CB  . GLN C 1 99  ? -19.614 28.075  148.225 1.00 93.98  ? 99  GLN C CB  1 
ATOM 3153 C CG  . GLN C 1 99  ? -19.744 27.130  149.396 1.00 93.98  ? 99  GLN C CG  1 
ATOM 3154 C CD  . GLN C 1 99  ? -21.179 26.726  149.654 1.00 93.98  ? 99  GLN C CD  1 
ATOM 3155 O OE1 . GLN C 1 99  ? -22.102 27.517  149.460 1.00 93.98  ? 99  GLN C OE1 1 
ATOM 3156 N NE2 . GLN C 1 99  ? -21.380 25.482  150.068 1.00 93.98  ? 99  GLN C NE2 1 
ATOM 3157 N N   . LEU C 1 100 ? -18.576 30.348  146.342 1.00 93.17  ? 100 LEU C N   1 
ATOM 3158 C CA  . LEU C 1 100 ? -18.631 30.921  144.997 1.00 93.17  ? 100 LEU C CA  1 
ATOM 3159 C C   . LEU C 1 100 ? -17.237 31.157  144.413 1.00 93.17  ? 100 LEU C C   1 
ATOM 3160 O O   . LEU C 1 100 ? -16.960 30.793  143.257 1.00 93.17  ? 100 LEU C O   1 
ATOM 3161 C CB  . LEU C 1 100 ? -19.445 32.215  145.024 1.00 93.17  ? 100 LEU C CB  1 
ATOM 3162 C CG  . LEU C 1 100 ? -19.744 32.884  143.681 1.00 93.17  ? 100 LEU C CG  1 
ATOM 3163 C CD1 . LEU C 1 100 ? -21.023 33.684  143.784 1.00 93.17  ? 100 LEU C CD1 1 
ATOM 3164 C CD2 . LEU C 1 100 ? -18.607 33.803  143.260 1.00 93.17  ? 100 LEU C CD2 1 
ATOM 3165 N N   . LEU C 1 101 ? -16.343 31.758  145.199 1.00 93.64  ? 101 LEU C N   1 
ATOM 3166 C CA  . LEU C 1 101 ? -14.966 31.947  144.760 1.00 93.64  ? 101 LEU C CA  1 
ATOM 3167 C C   . LEU C 1 101 ? -14.258 30.627  144.485 1.00 93.64  ? 101 LEU C C   1 
ATOM 3168 O O   . LEU C 1 101 ? -13.552 30.503  143.477 1.00 93.64  ? 101 LEU C O   1 
ATOM 3169 C CB  . LEU C 1 101 ? -14.191 32.739  145.812 1.00 93.64  ? 101 LEU C CB  1 
ATOM 3170 C CG  . LEU C 1 101 ? -14.496 34.231  145.942 1.00 93.64  ? 101 LEU C CG  1 
ATOM 3171 C CD1 . LEU C 1 101 ? -13.748 34.818  147.124 1.00 93.64  ? 101 LEU C CD1 1 
ATOM 3172 C CD2 . LEU C 1 101 ? -14.144 34.976  144.667 1.00 93.64  ? 101 LEU C CD2 1 
ATOM 3173 N N   . TRP C 1 102 ? -14.400 29.634  145.367 1.00 89.34  ? 102 TRP C N   1 
ATOM 3174 C CA  . TRP C 1 102 ? -13.762 28.352  145.088 1.00 89.34  ? 102 TRP C CA  1 
ATOM 3175 C C   . TRP C 1 102 ? -14.238 27.776  143.764 1.00 89.34  ? 102 TRP C C   1 
ATOM 3176 O O   . TRP C 1 102 ? -13.425 27.322  142.948 1.00 89.34  ? 102 TRP C O   1 
ATOM 3177 C CB  . TRP C 1 102 ? -14.033 27.358  146.214 1.00 89.34  ? 102 TRP C CB  1 
ATOM 3178 C CG  . TRP C 1 102 ? -13.420 26.014  145.952 1.00 89.34  ? 102 TRP C CG  1 
ATOM 3179 C CD1 . TRP C 1 102 ? -12.181 25.592  146.331 1.00 89.34  ? 102 TRP C CD1 1 
ATOM 3180 C CD2 . TRP C 1 102 ? -14.013 24.922  145.239 1.00 89.34  ? 102 TRP C CD2 1 
ATOM 3181 N NE1 . TRP C 1 102 ? -11.972 24.301  145.916 1.00 89.34  ? 102 TRP C NE1 1 
ATOM 3182 C CE2 . TRP C 1 102 ? -13.073 23.875  145.221 1.00 89.34  ? 102 TRP C CE2 1 
ATOM 3183 C CE3 . TRP C 1 102 ? -15.243 24.734  144.603 1.00 89.34  ? 102 TRP C CE3 1 
ATOM 3184 C CZ2 . TRP C 1 102 ? -13.327 22.655  144.603 1.00 89.34  ? 102 TRP C CZ2 1 
ATOM 3185 C CZ3 . TRP C 1 102 ? -15.501 23.513  144.009 1.00 89.34  ? 102 TRP C CZ3 1 
ATOM 3186 C CH2 . TRP C 1 102 ? -14.544 22.494  144.003 1.00 89.34  ? 102 TRP C CH2 1 
ATOM 3187 N N   . PHE C 1 103 ? -15.539 27.881  143.484 1.00 88.70  ? 103 PHE C N   1 
ATOM 3188 C CA  . PHE C 1 103 ? -16.061 27.331  142.237 1.00 88.70  ? 103 PHE C CA  1 
ATOM 3189 C C   . PHE C 1 103 ? -15.502 28.049  141.015 1.00 88.70  ? 103 PHE C C   1 
ATOM 3190 O O   . PHE C 1 103 ? -15.025 27.404  140.072 1.00 88.70  ? 103 PHE C O   1 
ATOM 3191 C CB  . PHE C 1 103 ? -17.587 27.392  142.232 1.00 88.70  ? 103 PHE C CB  1 
ATOM 3192 C CG  . PHE C 1 103 ? -18.204 26.862  140.971 1.00 88.70  ? 103 PHE C CG  1 
ATOM 3193 C CD1 . PHE C 1 103 ? -18.351 25.500  140.778 1.00 88.70  ? 103 PHE C CD1 1 
ATOM 3194 C CD2 . PHE C 1 103 ? -18.647 27.723  139.984 1.00 88.70  ? 103 PHE C CD2 1 
ATOM 3195 C CE1 . PHE C 1 103 ? -18.916 25.008  139.621 1.00 88.70  ? 103 PHE C CE1 1 
ATOM 3196 C CE2 . PHE C 1 103 ? -19.236 27.236  138.834 1.00 88.70  ? 103 PHE C CE2 1 
ATOM 3197 C CZ  . PHE C 1 103 ? -19.364 25.877  138.651 1.00 88.70  ? 103 PHE C CZ  1 
ATOM 3198 N N   . HIS C 1 104 ? -15.489 29.382  141.029 1.00 91.44  ? 104 HIS C N   1 
ATOM 3199 C CA  . HIS C 1 104 ? -15.038 30.082  139.826 1.00 91.44  ? 104 HIS C CA  1 
ATOM 3200 C C   . HIS C 1 104 ? -13.526 29.985  139.636 1.00 91.44  ? 104 HIS C C   1 
ATOM 3201 O O   . HIS C 1 104 ? -13.052 29.797  138.505 1.00 91.44  ? 104 HIS C O   1 
ATOM 3202 C CB  . HIS C 1 104 ? -15.478 31.543  139.877 1.00 91.44  ? 104 HIS C CB  1 
ATOM 3203 C CG  . HIS C 1 104 ? -16.930 31.742  139.577 1.00 91.44  ? 104 HIS C CG  1 
ATOM 3204 N ND1 . HIS C 1 104 ? -17.477 31.464  138.344 1.00 91.44  ? 104 HIS C ND1 1 
ATOM 3205 C CD2 . HIS C 1 104 ? -17.949 32.191  140.346 1.00 91.44  ? 104 HIS C CD2 1 
ATOM 3206 C CE1 . HIS C 1 104 ? -18.769 31.736  138.364 1.00 91.44  ? 104 HIS C CE1 1 
ATOM 3207 N NE2 . HIS C 1 104 ? -19.084 32.163  139.572 1.00 91.44  ? 104 HIS C NE2 1 
ATOM 3208 N N   . ILE C 1 105 ? -12.750 30.097  140.713 1.00 94.21  ? 105 ILE C N   1 
ATOM 3209 C CA  . ILE C 1 105 ? -11.301 29.974  140.589 1.00 94.21  ? 105 ILE C CA  1 
ATOM 3210 C C   . ILE C 1 105 ? -10.910 28.573  140.129 1.00 94.21  ? 105 ILE C C   1 
ATOM 3211 O O   . ILE C 1 105 ? -10.012 28.411  139.290 1.00 94.21  ? 105 ILE C O   1 
ATOM 3212 C CB  . ILE C 1 105 ? -10.612 30.352  141.913 1.00 94.21  ? 105 ILE C CB  1 
ATOM 3213 C CG1 . ILE C 1 105 ? -10.868 31.830  142.232 1.00 94.21  ? 105 ILE C CG1 1 
ATOM 3214 C CG2 . ILE C 1 105 ? -9.115  30.083  141.832 1.00 94.21  ? 105 ILE C CG2 1 
ATOM 3215 C CD1 . ILE C 1 105 ? -10.477 32.237  143.625 1.00 94.21  ? 105 ILE C CD1 1 
ATOM 3216 N N   . SER C 1 106 ? -11.586 27.537  140.640 1.00 94.20  ? 106 SER C N   1 
ATOM 3217 C CA  . SER C 1 106 ? -11.295 26.190  140.163 1.00 94.20  ? 106 SER C CA  1 
ATOM 3218 C C   . SER C 1 106 ? -11.687 26.011  138.702 1.00 94.20  ? 106 SER C C   1 
ATOM 3219 O O   . SER C 1 106 ? -10.956 25.373  137.938 1.00 94.20  ? 106 SER C O   1 
ATOM 3220 C CB  . SER C 1 106 ? -12.012 25.162  141.037 1.00 94.20  ? 106 SER C CB  1 
ATOM 3221 O OG  . SER C 1 106 ? -11.630 25.293  142.394 1.00 94.20  ? 106 SER C OG  1 
ATOM 3222 N N   . CYS C 1 107 ? -12.832 26.559  138.286 1.00 96.54  ? 107 CYS C N   1 
ATOM 3223 C CA  . CYS C 1 107 ? -13.212 26.430  136.884 1.00 96.54  ? 107 CYS C CA  1 
ATOM 3224 C C   . CYS C 1 107 ? -12.195 27.097  135.966 1.00 96.54  ? 107 CYS C C   1 
ATOM 3225 O O   . CYS C 1 107 ? -11.860 26.558  134.905 1.00 96.54  ? 107 CYS C O   1 
ATOM 3226 C CB  . CYS C 1 107 ? -14.604 27.020  136.652 1.00 96.54  ? 107 CYS C CB  1 
ATOM 3227 S SG  . CYS C 1 107 ? -15.960 25.994  137.257 1.00 96.54  ? 107 CYS C SG  1 
ATOM 3228 N N   . LEU C 1 108 ? -11.695 28.272  136.353 1.00 92.79  ? 108 LEU C N   1 
ATOM 3229 C CA  . LEU C 1 108 ? -10.668 28.932  135.547 1.00 92.79  ? 108 LEU C CA  1 
ATOM 3230 C C   . LEU C 1 108 ? -9.346  28.166  135.533 1.00 92.79  ? 108 LEU C C   1 
ATOM 3231 O O   . LEU C 1 108 ? -8.684  28.093  134.492 1.00 92.79  ? 108 LEU C O   1 
ATOM 3232 C CB  . LEU C 1 108 ? -10.437 30.359  136.042 1.00 92.79  ? 108 LEU C CB  1 
ATOM 3233 C CG  . LEU C 1 108 ? -11.566 31.361  135.800 1.00 92.79  ? 108 LEU C CG  1 
ATOM 3234 C CD1 . LEU C 1 108 ? -11.252 32.689  136.468 1.00 92.79  ? 108 LEU C CD1 1 
ATOM 3235 C CD2 . LEU C 1 108 ? -11.791 31.556  134.308 1.00 92.79  ? 108 LEU C CD2 1 
ATOM 3236 N N   . THR C 1 109 ? -8.939  27.592  136.667 1.00 94.50  ? 109 THR C N   1 
ATOM 3237 C CA  . THR C 1 109 ? -7.676  26.854  136.699 1.00 94.50  ? 109 THR C CA  1 
ATOM 3238 C C   . THR C 1 109 ? -7.746  25.505  135.983 1.00 94.50  ? 109 THR C C   1 
ATOM 3239 O O   . THR C 1 109 ? -6.830  25.158  135.229 1.00 94.50  ? 109 THR C O   1 
ATOM 3240 C CB  . THR C 1 109 ? -7.226  26.654  138.145 1.00 94.50  ? 109 THR C CB  1 
ATOM 3241 O OG1 . THR C 1 109 ? -7.282  27.904  138.843 1.00 94.50  ? 109 THR C OG1 1 
ATOM 3242 C CG2 . THR C 1 109 ? -5.801  26.127  138.188 1.00 94.50  ? 109 THR C CG2 1 
ATOM 3243 N N   . PHE C 1 110 ? -8.814  24.730  136.190 1.00 96.42  ? 110 PHE C N   1 
ATOM 3244 C CA  . PHE C 1 110 ? -8.849  23.342  135.736 1.00 96.42  ? 110 PHE C CA  1 
ATOM 3245 C C   . PHE C 1 110 ? -9.901  23.017  134.683 1.00 96.42  ? 110 PHE C C   1 
ATOM 3246 O O   . PHE C 1 110 ? -9.922  21.881  134.196 1.00 96.42  ? 110 PHE C O   1 
ATOM 3247 C CB  . PHE C 1 110 ? -9.039  22.398  136.932 1.00 96.42  ? 110 PHE C CB  1 
ATOM 3248 C CG  . PHE C 1 110 ? -7.988  22.557  137.995 1.00 96.42  ? 110 PHE C CG  1 
ATOM 3249 C CD1 . PHE C 1 110 ? -6.717  22.046  137.809 1.00 96.42  ? 110 PHE C CD1 1 
ATOM 3250 C CD2 . PHE C 1 110 ? -8.278  23.197  139.185 1.00 96.42  ? 110 PHE C CD2 1 
ATOM 3251 C CE1 . PHE C 1 110 ? -5.751  22.180  138.786 1.00 96.42  ? 110 PHE C CE1 1 
ATOM 3252 C CE2 . PHE C 1 110 ? -7.315  23.338  140.163 1.00 96.42  ? 110 PHE C CE2 1 
ATOM 3253 C CZ  . PHE C 1 110 ? -6.051  22.830  139.962 1.00 96.42  ? 110 PHE C CZ  1 
ATOM 3254 N N   . GLY C 1 111 ? -10.778 23.975  134.371 1.00 96.83  ? 111 GLY C N   1 
ATOM 3255 C CA  . GLY C 1 111 ? -11.889 23.698  133.438 1.00 96.83  ? 111 GLY C CA  1 
ATOM 3256 C C   . GLY C 1 111 ? -13.156 23.377  134.211 1.00 96.83  ? 111 GLY C C   1 
ATOM 3257 O O   . GLY C 1 111 ? -13.092 22.492  135.083 1.00 96.83  ? 111 GLY C O   1 
ATOM 3258 N N   . ARG C 1 112 ? -14.268 24.051  133.902 1.00 98.50  ? 112 ARG C N   1 
ATOM 3259 C CA  . ARG C 1 112 ? -15.521 23.865  134.687 1.00 98.50  ? 112 ARG C CA  1 
ATOM 3260 C C   . ARG C 1 112 ? -15.918 22.386  134.730 1.00 98.50  ? 112 ARG C C   1 
ATOM 3261 O O   . ARG C 1 112 ? -16.202 21.890  135.839 1.00 98.50  ? 112 ARG C O   1 
ATOM 3262 C CB  . ARG C 1 112 ? -16.656 24.690  134.073 1.00 98.50  ? 112 ARG C CB  1 
ATOM 3263 C CG  . ARG C 1 112 ? -17.994 24.521  134.779 1.00 98.50  ? 112 ARG C CG  1 
ATOM 3264 C CD  . ARG C 1 112 ? -19.124 25.178  134.011 1.00 98.50  ? 112 ARG C CD  1 
ATOM 3265 N NE  . ARG C 1 112 ? -19.248 24.625  132.671 1.00 98.50  ? 112 ARG C NE  1 
ATOM 3266 C CZ  . ARG C 1 112 ? -19.978 23.561  132.361 1.00 98.50  ? 112 ARG C CZ  1 
ATOM 3267 N NH1 . ARG C 1 112 ? -20.658 22.927  133.301 1.00 98.50  ? 112 ARG C NH1 1 
ATOM 3268 N NH2 . ARG C 1 112 ? -20.026 23.132  131.112 1.00 98.50  ? 112 ARG C NH2 1 
ATOM 3269 N N   . GLU C 1 113 ? -15.939 21.713  133.577 1.00 104.35 ? 113 GLU C N   1 
ATOM 3270 C CA  . GLU C 1 113 ? -16.393 20.297  133.531 1.00 104.35 ? 113 GLU C CA  1 
ATOM 3271 C C   . GLU C 1 113 ? -15.492 19.446  134.431 1.00 104.35 ? 113 GLU C C   1 
ATOM 3272 O O   . GLU C 1 113 ? -16.036 18.668  135.239 1.00 104.35 ? 113 GLU C O   1 
ATOM 3273 C CB  . GLU C 1 113 ? -16.377 19.785  132.091 1.00 104.35 ? 113 GLU C CB  1 
ATOM 3274 C CG  . GLU C 1 113 ? -17.223 20.624  131.150 1.00 104.35 ? 113 GLU C CG  1 
ATOM 3275 C CD  . GLU C 1 113 ? -17.216 20.157  129.705 1.00 104.35 ? 113 GLU C CD  1 
ATOM 3276 O OE1 . GLU C 1 113 ? -16.522 19.165  129.410 1.00 104.35 ? 113 GLU C OE1 1 
ATOM 3277 O OE2 . GLU C 1 113 ? -17.906 20.787  128.879 1.00 104.35 ? 113 GLU C OE2 1 
ATOM 3278 N N   . THR C 1 114 ? -14.172 19.603  134.304 1.00 102.28 ? 114 THR C N   1 
ATOM 3279 C CA  . THR C 1 114 ? -13.215 18.807  135.118 1.00 102.28 ? 114 THR C CA  1 
ATOM 3280 C C   . THR C 1 114 ? -13.470 19.077  136.603 1.00 102.28 ? 114 THR C C   1 
ATOM 3281 O O   . THR C 1 114 ? -13.495 18.107  137.379 1.00 102.28 ? 114 THR C O   1 
ATOM 3282 C CB  . THR C 1 114 ? -11.766 19.128  134.733 1.00 102.28 ? 114 THR C CB  1 
ATOM 3283 O OG1 . THR C 1 114 ? -11.601 18.829  133.346 1.00 102.28 ? 114 THR C OG1 1 
ATOM 3284 C CG2 . THR C 1 114 ? -10.754 18.352  135.548 1.00 102.28 ? 114 THR C CG2 1 
ATOM 3285 N N   . VAL C 1 115 ? -13.665 20.346  136.972 1.00 97.28  ? 115 VAL C N   1 
ATOM 3286 C CA  . VAL C 1 115 ? -13.900 20.719  138.398 1.00 97.28  ? 115 VAL C CA  1 
ATOM 3287 C C   . VAL C 1 115 ? -15.167 20.015  138.894 1.00 97.28  ? 115 VAL C C   1 
ATOM 3288 O O   . VAL C 1 115 ? -15.127 19.456  140.000 1.00 97.28  ? 115 VAL C O   1 
ATOM 3289 C CB  . VAL C 1 115 ? -14.008 22.246  138.564 1.00 97.28  ? 115 VAL C CB  1 
ATOM 3290 C CG1 . VAL C 1 115 ? -14.374 22.635  139.988 1.00 97.28  ? 115 VAL C CG1 1 
ATOM 3291 C CG2 . VAL C 1 115 ? -12.730 22.943  138.128 1.00 97.28  ? 115 VAL C CG2 1 
ATOM 3292 N N   . ILE C 1 116 ? -16.240 20.042  138.099 1.00 95.85  ? 116 ILE C N   1 
ATOM 3293 C CA  . ILE C 1 116 ? -17.527 19.396  138.499 1.00 95.85  ? 116 ILE C CA  1 
ATOM 3294 C C   . ILE C 1 116 ? -17.292 17.892  138.675 1.00 95.85  ? 116 ILE C C   1 
ATOM 3295 O O   . ILE C 1 116 ? -17.802 17.322  139.665 1.00 95.85  ? 116 ILE C O   1 
ATOM 3296 C CB  . ILE C 1 116 ? -18.626 19.688  137.458 1.00 30.00  ? 116 ILE C CB  1 
ATOM 3297 C CG1 . ILE C 1 116 ? -18.829 21.192  137.260 1.00 30.00  ? 116 ILE C CG1 1 
ATOM 3298 C CG2 . ILE C 1 116 ? -19.923 18.988  137.832 1.00 30.00  ? 116 ILE C CG2 1 
ATOM 3299 C CD1 . ILE C 1 116 ? -19.850 21.540  136.202 1.00 30.00  ? 116 ILE C CD1 1 
ATOM 3300 N N   . GLU C 1 117 ? -16.543 17.279  137.753 1.00 100.08 ? 117 GLU C N   1 
ATOM 3301 C CA  . GLU C 1 117 ? -16.240 15.827  137.852 1.00 100.08 ? 117 GLU C CA  1 
ATOM 3302 C C   . GLU C 1 117 ? -15.534 15.568  139.183 1.00 100.08 ? 117 GLU C C   1 
ATOM 3303 O O   . GLU C 1 117 ? -15.958 14.645  139.913 1.00 100.08 ? 117 GLU C O   1 
ATOM 3304 C CB  . GLU C 1 117 ? -15.349 15.396  136.687 1.00 100.08 ? 117 GLU C CB  1 
ATOM 3305 C CG  . GLU C 1 117 ? -15.932 15.723  135.326 1.00 100.08 ? 117 GLU C CG  1 
ATOM 3306 C CD  . GLU C 1 117 ? -14.901 15.863  134.220 1.00 100.08 ? 117 GLU C CD  1 
ATOM 3307 O OE1 . GLU C 1 117 ? -13.704 15.649  134.499 1.00 100.08 ? 117 GLU C OE1 1 
ATOM 3308 O OE2 . GLU C 1 117 ? -15.295 16.194  133.084 1.00 100.08 ? 117 GLU C OE2 1 
ATOM 3309 N N   . TYR C 1 118 ? -14.515 16.375  139.493 1.00 96.05  ? 118 TYR C N   1 
ATOM 3310 C CA  . TYR C 1 118 ? -13.758 16.195  140.758 1.00 96.05  ? 118 TYR C CA  1 
ATOM 3311 C C   . TYR C 1 118 ? -14.727 16.307  141.935 1.00 96.05  ? 118 TYR C C   1 
ATOM 3312 O O   . TYR C 1 118 ? -14.680 15.439  142.808 1.00 96.05  ? 118 TYR C O   1 
ATOM 3313 C CB  . TYR C 1 118 ? -12.646 17.237  140.886 1.00 96.05  ? 118 TYR C CB  1 
ATOM 3314 C CG  . TYR C 1 118 ? -12.027 17.295  142.259 1.00 96.05  ? 118 TYR C CG  1 
ATOM 3315 C CD1 . TYR C 1 118 ? -11.057 16.386  142.644 1.00 96.05  ? 118 TYR C CD1 1 
ATOM 3316 C CD2 . TYR C 1 118 ? -12.424 18.247  143.183 1.00 96.05  ? 118 TYR C CD2 1 
ATOM 3317 C CE1 . TYR C 1 118 ? -10.489 16.427  143.905 1.00 96.05  ? 118 TYR C CE1 1 
ATOM 3318 C CE2 . TYR C 1 118 ? -11.866 18.303  144.449 1.00 96.05  ? 118 TYR C CE2 1 
ATOM 3319 C CZ  . TYR C 1 118 ? -10.894 17.388  144.812 1.00 96.05  ? 118 TYR C CZ  1 
ATOM 3320 O OH  . TYR C 1 118 ? -10.338 17.435  146.058 1.00 96.05  ? 118 TYR C OH  1 
ATOM 3321 N N   . LEU C 1 119 ? -15.580 17.333  141.935 1.00 94.61  ? 119 LEU C N   1 
ATOM 3322 C CA  . LEU C 1 119 ? -16.575 17.524  143.022 1.00 94.61  ? 119 LEU C CA  1 
ATOM 3323 C C   . LEU C 1 119 ? -17.368 16.230  143.199 1.00 94.61  ? 119 LEU C C   1 
ATOM 3324 O O   . LEU C 1 119 ? -17.381 15.694  144.327 1.00 94.61  ? 119 LEU C O   1 
ATOM 3325 C CB  . LEU C 1 119 ? -17.515 18.664  142.620 1.00 94.61  ? 119 LEU C CB  1 
ATOM 3326 C CG  . LEU C 1 119 ? -18.491 19.136  143.693 1.00 94.61  ? 119 LEU C CG  1 
ATOM 3327 C CD1 . LEU C 1 119 ? -18.759 20.628  143.564 1.00 94.61  ? 119 LEU C CD1 1 
ATOM 3328 C CD2 . LEU C 1 119 ? -19.793 18.357  143.609 1.00 94.61  ? 119 LEU C CD2 1 
ATOM 3329 N N   . VAL C 1 120 ? -17.974 15.736  142.116 1.00 93.61  ? 120 VAL C N   1 
ATOM 3330 C CA  . VAL C 1 120 ? -18.832 14.519  142.217 1.00 93.61  ? 120 VAL C CA  1 
ATOM 3331 C C   . VAL C 1 120 ? -18.001 13.377  142.810 1.00 93.61  ? 120 VAL C C   1 
ATOM 3332 O O   . VAL C 1 120 ? -18.465 12.760  143.786 1.00 93.61  ? 120 VAL C O   1 
ATOM 3333 C CB  . VAL C 1 120 ? -19.417 14.132  140.845 1.00 93.61  ? 120 VAL C CB  1 
ATOM 3334 C CG1 . VAL C 1 120 ? -20.235 12.853  140.923 1.00 93.61  ? 120 VAL C CG1 1 
ATOM 3335 C CG2 . VAL C 1 120 ? -20.242 15.261  140.248 1.00 93.61  ? 120 VAL C CG2 1 
ATOM 3336 N N   . SER C 1 121 ? -16.806 13.133  142.264 1.00 96.62  ? 121 SER C N   1 
ATOM 3337 C CA  . SER C 1 121 ? -15.983 11.988  142.735 1.00 96.62  ? 121 SER C CA  1 
ATOM 3338 C C   . SER C 1 121 ? -15.714 12.123  144.236 1.00 96.62  ? 121 SER C C   1 
ATOM 3339 O O   . SER C 1 121 ? -15.913 11.130  144.961 1.00 96.62  ? 121 SER C O   1 
ATOM 3340 C CB  . SER C 1 121 ? -14.698 11.906  141.956 1.00 96.62  ? 121 SER C CB  1 
ATOM 3341 O OG  . SER C 1 121 ? -13.894 13.054  142.184 1.00 96.62  ? 121 SER C OG  1 
ATOM 3342 N N   . PHE C 1 122 ? -15.303 13.311  144.682 1.00 93.70  ? 122 PHE C N   1 
ATOM 3343 C CA  . PHE C 1 122 ? -14.964 13.534  146.110 1.00 93.70  ? 122 PHE C CA  1 
ATOM 3344 C C   . PHE C 1 122 ? -16.202 13.282  146.975 1.00 93.70  ? 122 PHE C C   1 
ATOM 3345 O O   . PHE C 1 122 ? -16.085 12.579  147.987 1.00 93.70  ? 122 PHE C O   1 
ATOM 3346 C CB  . PHE C 1 122 ? -14.420 14.950  146.306 1.00 93.70  ? 122 PHE C CB  1 
ATOM 3347 C CG  . PHE C 1 122 ? -13.683 15.168  147.603 1.00 93.70  ? 122 PHE C CG  1 
ATOM 3348 C CD1 . PHE C 1 122 ? -12.341 14.841  147.718 1.00 93.70  ? 122 PHE C CD1 1 
ATOM 3349 C CD2 . PHE C 1 122 ? -14.329 15.698  148.707 1.00 93.70  ? 122 PHE C CD2 1 
ATOM 3350 C CE1 . PHE C 1 122 ? -11.662 15.041  148.909 1.00 93.70  ? 122 PHE C CE1 1 
ATOM 3351 C CE2 . PHE C 1 122 ? -13.648 15.898  149.899 1.00 93.70  ? 122 PHE C CE2 1 
ATOM 3352 C CZ  . PHE C 1 122 ? -12.317 15.568  149.997 1.00 93.70  ? 122 PHE C CZ  1 
ATOM 3353 N N   . GLY C 1 123 ? -17.355 13.825  146.570 1.00 91.92  ? 123 GLY C N   1 
ATOM 3354 C CA  . GLY C 1 123 ? -18.600 13.604  147.330 1.00 91.92  ? 123 GLY C CA  1 
ATOM 3355 C C   . GLY C 1 123 ? -18.908 12.121  147.449 1.00 91.92  ? 123 GLY C C   1 
ATOM 3356 O O   . GLY C 1 123 ? -19.252 11.673  148.564 1.00 91.92  ? 123 GLY C O   1 
ATOM 3357 N N   . VAL C 1 124 ? -18.768 11.381  146.345 1.00 92.39  ? 124 VAL C N   1 
ATOM 3358 C CA  . VAL C 1 124 ? -19.056 9.916   146.348 1.00 92.39  ? 124 VAL C CA  1 
ATOM 3359 C C   . VAL C 1 124 ? -18.096 9.225   147.323 1.00 92.39  ? 124 VAL C C   1 
ATOM 3360 O O   . VAL C 1 124 ? -18.565 8.397   148.125 1.00 92.39  ? 124 VAL C O   1 
ATOM 3361 C CB  . VAL C 1 124 ? -18.939 9.323   144.932 1.00 92.39  ? 124 VAL C CB  1 
ATOM 3362 C CG1 . VAL C 1 124 ? -19.058 7.807   144.941 1.00 92.39  ? 124 VAL C CG1 1 
ATOM 3363 C CG2 . VAL C 1 124 ? -19.952 9.938   143.979 1.00 92.39  ? 124 VAL C CG2 1 
ATOM 3364 N N   . TRP C 1 125 ? -16.806 9.566   147.258 1.00 92.64  ? 125 TRP C N   1 
ATOM 3365 C CA  . TRP C 1 125 ? -15.790 8.923   148.134 1.00 92.64  ? 125 TRP C CA  1 
ATOM 3366 C C   . TRP C 1 125 ? -16.114 9.228   149.599 1.00 92.64  ? 125 TRP C C   1 
ATOM 3367 O O   . TRP C 1 125 ? -15.879 8.347   150.452 1.00 92.64  ? 125 TRP C O   1 
ATOM 3368 C CB  . TRP C 1 125 ? -14.385 9.402   147.751 1.00 92.64  ? 125 TRP C CB  1 
ATOM 3369 C CG  . TRP C 1 125 ? -13.277 8.640   148.407 1.00 92.64  ? 125 TRP C CG  1 
ATOM 3370 C CD1 . TRP C 1 125 ? -12.787 7.421   148.039 1.00 92.64  ? 125 TRP C CD1 1 
ATOM 3371 C CD2 . TRP C 1 125 ? -12.506 9.053   149.550 1.00 92.64  ? 125 TRP C CD2 1 
ATOM 3372 N NE1 . TRP C 1 125 ? -11.770 7.046   148.873 1.00 92.64  ? 125 TRP C NE1 1 
ATOM 3373 C CE2 . TRP C 1 125 ? -11.574 8.026   149.809 1.00 92.64  ? 125 TRP C CE2 1 
ATOM 3374 C CE3 . TRP C 1 125 ? -12.513 10.182  150.375 1.00 92.64  ? 125 TRP C CE3 1 
ATOM 3375 C CZ2 . TRP C 1 125 ? -10.661 8.100   150.860 1.00 92.64  ? 125 TRP C CZ2 1 
ATOM 3376 C CZ3 . TRP C 1 125 ? -11.611 10.253  151.413 1.00 92.64  ? 125 TRP C CZ3 1 
ATOM 3377 C CH2 . TRP C 1 125 ? -10.698 9.225   151.650 1.00 92.64  ? 125 TRP C CH2 1 
ATOM 3378 N N   . ILE C 1 126 ? -16.638 10.402  149.924 1.00 93.49  ? 126 ILE C N   1 
ATOM 3379 C CA  . ILE C 1 126 ? -16.874 10.739  151.357 1.00 93.49  ? 126 ILE C CA  1 
ATOM 3380 C C   . ILE C 1 126 ? -18.063 9.907   151.838 1.00 93.49  ? 126 ILE C C   1 
ATOM 3381 O O   . ILE C 1 126 ? -18.134 9.680   153.054 1.00 93.49  ? 126 ILE C O   1 
ATOM 3382 C CB  . ILE C 1 126 ? -17.067 12.250  151.604 1.00 93.49  ? 126 ILE C CB  1 
ATOM 3383 C CG1 . ILE C 1 126 ? -17.200 12.562  153.095 1.00 93.49  ? 126 ILE C CG1 1 
ATOM 3384 C CG2 . ILE C 1 126 ? -18.241 12.799  150.816 1.00 93.49  ? 126 ILE C CG2 1 
ATOM 3385 C CD1 . ILE C 1 126 ? -17.142 14.035  153.416 1.00 93.49  ? 126 ILE C CD1 1 
ATOM 3386 N N   . ARG C 1 127 ? -18.954 9.438   150.951 1.00 94.06  ? 127 ARG C N   1 
ATOM 3387 C CA  . ARG C 1 127 ? -20.023 8.555   151.422 1.00 94.06  ? 127 ARG C CA  1 
ATOM 3388 C C   . ARG C 1 127 ? -19.568 7.110   151.639 1.00 94.06  ? 127 ARG C C   1 
ATOM 3389 O O   . ARG C 1 127 ? -20.145 6.413   152.481 1.00 94.06  ? 127 ARG C O   1 
ATOM 3390 C CB  . ARG C 1 127 ? -21.214 8.606   150.466 1.00 94.06  ? 127 ARG C CB  1 
ATOM 3391 C CG  . ARG C 1 127 ? -22.255 9.654   150.853 1.00 94.06  ? 127 ARG C CG  1 
ATOM 3392 C CD  . ARG C 1 127 ? -21.837 11.079  150.552 1.00 94.06  ? 127 ARG C CD  1 
ATOM 3393 N NE  . ARG C 1 127 ? -22.853 12.024  151.003 1.00 94.06  ? 127 ARG C NE  1 
ATOM 3394 C CZ  . ARG C 1 127 ? -22.818 13.331  150.784 1.00 94.06  ? 127 ARG C CZ  1 
ATOM 3395 N NH1 . ARG C 1 127 ? -21.833 13.894  150.104 1.00 94.06  ? 127 ARG C NH1 1 
ATOM 3396 N NH2 . ARG C 1 127 ? -23.785 14.096  151.281 1.00 94.06  ? 127 ARG C NH2 1 
ATOM 3397 N N   . THR C 1 128 ? -18.549 6.637   150.919 1.00 93.23  ? 128 THR C N   1 
ATOM 3398 C CA  . THR C 1 128 ? -18.193 5.217   150.991 1.00 93.23  ? 128 THR C CA  1 
ATOM 3399 C C   . THR C 1 128 ? -17.478 4.872   152.303 1.00 93.23  ? 128 THR C C   1 
ATOM 3400 O O   . THR C 1 128 ? -16.607 5.619   152.752 1.00 93.23  ? 128 THR C O   1 
ATOM 3401 C CB  . THR C 1 128 ? -17.300 4.831   149.817 1.00 93.23  ? 128 THR C CB  1 
ATOM 3402 O OG1 . THR C 1 128 ? -17.950 5.169   148.586 1.00 93.23  ? 128 THR C OG1 1 
ATOM 3403 C CG2 . THR C 1 128 ? -17.014 3.337   149.838 1.00 93.23  ? 128 THR C CG2 1 
ATOM 3404 N N   . PRO C 1 129 ? -17.835 3.745   152.939 1.00 91.15  ? 129 PRO C N   1 
ATOM 3405 C CA  . PRO C 1 129 ? -17.185 3.376   154.201 1.00 91.15  ? 129 PRO C CA  1 
ATOM 3406 C C   . PRO C 1 129 ? -15.714 3.053   154.003 1.00 91.15  ? 129 PRO C C   1 
ATOM 3407 O O   . PRO C 1 129 ? -15.318 2.496   152.966 1.00 91.15  ? 129 PRO C O   1 
ATOM 3408 C CB  . PRO C 1 129 ? -17.974 2.132   154.656 1.00 91.15  ? 129 PRO C CB  1 
ATOM 3409 C CG  . PRO C 1 129 ? -19.278 2.245   153.978 1.00 91.15  ? 129 PRO C CG  1 
ATOM 3410 C CD  . PRO C 1 129 ? -18.959 2.843   152.642 1.00 91.15  ? 129 PRO C CD  1 
ATOM 3411 N N   . PRO C 1 130 ? -14.865 3.376   154.986 1.00 92.03  ? 130 PRO C N   1 
ATOM 3412 C CA  . PRO C 1 130 ? -13.410 3.397   154.745 1.00 92.03  ? 130 PRO C CA  1 
ATOM 3413 C C   . PRO C 1 130 ? -12.771 2.046   154.446 1.00 92.03  ? 130 PRO C C   1 
ATOM 3414 O O   . PRO C 1 130 ? -11.713 2.024   153.806 1.00 92.03  ? 130 PRO C O   1 
ATOM 3415 C CB  . PRO C 1 130 ? -12.849 3.970   156.057 1.00 92.03  ? 130 PRO C CB  1 
ATOM 3416 C CG  . PRO C 1 130 ? -13.895 3.667   157.073 1.00 92.03  ? 130 PRO C CG  1 
ATOM 3417 C CD  . PRO C 1 130 ? -15.189 3.836   156.344 1.00 92.03  ? 130 PRO C CD  1 
ATOM 3418 N N   . ALA C 1 131 ? -13.356 0.924   154.871 1.00 89.06  ? 131 ALA C N   1 
ATOM 3419 C CA  . ALA C 1 131 ? -12.802 -0.374  154.495 1.00 89.06  ? 131 ALA C CA  1 
ATOM 3420 C C   . ALA C 1 131 ? -12.940 -0.682  153.009 1.00 89.06  ? 131 ALA C C   1 
ATOM 3421 O O   . ALA C 1 131 ? -12.249 -1.575  152.512 1.00 89.06  ? 131 ALA C O   1 
ATOM 3422 C CB  . ALA C 1 131 ? -13.471 -1.484  155.306 1.00 89.06  ? 131 ALA C CB  1 
ATOM 3423 N N   . TYR C 1 132 ? -13.811 0.025   152.295 1.00 89.32  ? 132 TYR C N   1 
ATOM 3424 C CA  . TYR C 1 132 ? -14.240 -0.375  150.960 1.00 89.32  ? 132 TYR C CA  1 
ATOM 3425 C C   . TYR C 1 132 ? -14.021 0.737   149.939 1.00 89.32  ? 132 TYR C C   1 
ATOM 3426 O O   . TYR C 1 132 ? -14.747 0.820   148.946 1.00 89.32  ? 132 TYR C O   1 
ATOM 3427 C CB  . TYR C 1 132 ? -15.694 -0.844  150.967 1.00 89.32  ? 132 TYR C CB  1 
ATOM 3428 C CG  . TYR C 1 132 ? -15.948 -1.962  151.956 1.00 89.32  ? 132 TYR C CG  1 
ATOM 3429 C CD1 . TYR C 1 132 ? -15.517 -3.253  151.686 1.00 89.32  ? 132 TYR C CD1 1 
ATOM 3430 C CD2 . TYR C 1 132 ? -16.624 -1.734  153.144 1.00 89.32  ? 132 TYR C CD2 1 
ATOM 3431 C CE1 . TYR C 1 132 ? -15.735 -4.282  152.577 1.00 89.32  ? 132 TYR C CE1 1 
ATOM 3432 C CE2 . TYR C 1 132 ? -16.871 -2.766  154.033 1.00 89.32  ? 132 TYR C CE2 1 
ATOM 3433 C CZ  . TYR C 1 132 ? -16.413 -4.035  153.748 1.00 89.32  ? 132 TYR C CZ  1 
ATOM 3434 O OH  . TYR C 1 132 ? -16.629 -5.062  154.635 1.00 89.32  ? 132 TYR C OH  1 
ATOM 3435 N N   . ARG C 1 133 ? -13.034 1.594   150.161 1.00 91.91  ? 133 ARG C N   1 
ATOM 3436 C CA  . ARG C 1 133 ? -12.735 2.687   149.249 1.00 91.91  ? 133 ARG C CA  1 
ATOM 3437 C C   . ARG C 1 133 ? -11.230 2.855   149.113 1.00 91.91  ? 133 ARG C C   1 
ATOM 3438 O O   . ARG C 1 133 ? -10.468 2.406   149.976 1.00 91.91  ? 133 ARG C O   1 
ATOM 3439 C CB  . ARG C 1 133 ? -13.359 3.993   149.758 1.00 91.91  ? 133 ARG C CB  1 
ATOM 3440 C CG  . ARG C 1 133 ? -12.732 4.486   151.053 1.00 91.91  ? 133 ARG C CG  1 
ATOM 3441 C CD  . ARG C 1 133 ? -13.409 5.731   151.587 1.00 91.91  ? 133 ARG C CD  1 
ATOM 3442 N NE  . ARG C 1 133 ? -12.681 6.280   152.725 1.00 91.91  ? 133 ARG C NE  1 
ATOM 3443 C CZ  . ARG C 1 133 ? -13.142 7.231   153.525 1.00 91.91  ? 133 ARG C CZ  1 
ATOM 3444 N NH1 . ARG C 1 133 ? -14.289 7.842   153.285 1.00 91.91  ? 133 ARG C NH1 1 
ATOM 3445 N NH2 . ARG C 1 133 ? -12.421 7.592   154.583 1.00 91.91  ? 133 ARG C NH2 1 
ATOM 3446 N N   . PRO C 1 134 ? -10.772 3.494   148.037 1.00 92.93  ? 134 PRO C N   1 
ATOM 3447 C CA  . PRO C 1 134 ? -9.349  3.837   147.910 1.00 92.93  ? 134 PRO C CA  1 
ATOM 3448 C C   . PRO C 1 134 ? -8.870  4.706   149.059 1.00 92.93  ? 134 PRO C C   1 
ATOM 3449 O O   . PRO C 1 134 ? -9.610  5.578   149.540 1.00 92.93  ? 134 PRO C O   1 
ATOM 3450 C CB  . PRO C 1 134 ? -9.286  4.594   146.575 1.00 92.93  ? 134 PRO C CB  1 
ATOM 3451 C CG  . PRO C 1 134 ? -10.455 4.104   145.809 1.00 92.93  ? 134 PRO C CG  1 
ATOM 3452 C CD  . PRO C 1 134 ? -11.529 3.864   146.831 1.00 92.93  ? 134 PRO C CD  1 
ATOM 3453 N N   . PRO C 1 135 ? -7.635  4.502   149.530 1.00 95.02  ? 135 PRO C N   1 
ATOM 3454 C CA  . PRO C 1 135 ? -7.227  5.107   150.808 1.00 95.02  ? 135 PRO C CA  1 
ATOM 3455 C C   . PRO C 1 135 ? -6.917  6.596   150.744 1.00 95.02  ? 135 PRO C C   1 
ATOM 3456 O O   . PRO C 1 135 ? -6.943  7.251   151.795 1.00 95.02  ? 135 PRO C O   1 
ATOM 3457 C CB  . PRO C 1 135 ? -5.969  4.312   151.187 1.00 95.02  ? 135 PRO C CB  1 
ATOM 3458 C CG  . PRO C 1 135 ? -5.425  3.841   149.887 1.00 95.02  ? 135 PRO C CG  1 
ATOM 3459 C CD  . PRO C 1 135 ? -6.619  3.565   149.022 1.00 95.02  ? 135 PRO C CD  1 
ATOM 3460 N N   . ASN C 1 136 ? -6.630  7.155   149.569 1.00 100.61 ? 136 ASN C N   1 
ATOM 3461 C CA  . ASN C 1 136 ? -6.262  8.563   149.439 1.00 100.61 ? 136 ASN C CA  1 
ATOM 3462 C C   . ASN C 1 136 ? -7.426  9.391   148.909 1.00 100.61 ? 136 ASN C C   1 
ATOM 3463 O O   . ASN C 1 136 ? -8.057  9.022   147.914 1.00 100.61 ? 136 ASN C O   1 
ATOM 3464 C CB  . ASN C 1 136 ? -5.053  8.721   148.516 1.00 100.61 ? 136 ASN C CB  1 
ATOM 3465 C CG  . ASN C 1 136 ? -3.790  8.125   149.102 1.00 100.61 ? 136 ASN C CG  1 
ATOM 3466 O OD1 . ASN C 1 136 ? -2.936  8.841   149.625 1.00 100.61 ? 136 ASN C OD1 1 
ATOM 3467 N ND2 . ASN C 1 136 ? -3.660  6.809   149.010 1.00 100.61 ? 136 ASN C ND2 1 
ATOM 3468 N N   . ALA C 1 137 ? -7.703  10.507  149.579 1.00 98.08  ? 137 ALA C N   1 
ATOM 3469 C CA  . ALA C 1 137 ? -8.781  11.389  149.160 1.00 98.08  ? 137 ALA C CA  1 
ATOM 3470 C C   . ALA C 1 137 ? -8.475  12.007  147.795 1.00 98.08  ? 137 ALA C C   1 
ATOM 3471 O O   . ALA C 1 137 ? -7.317  12.329  147.507 1.00 98.08  ? 137 ALA C O   1 
ATOM 3472 C CB  . ALA C 1 137 ? -8.996  12.494  150.193 1.00 98.08  ? 137 ALA C CB  1 
ATOM 3473 N N   . PRO C 1 138 ? -9.479  12.186  146.933 1.00 100.43 ? 138 PRO C N   1 
ATOM 3474 C CA  . PRO C 1 138 ? -9.226  12.803  145.623 1.00 100.43 ? 138 PRO C CA  1 
ATOM 3475 C C   . PRO C 1 138 ? -8.809  14.261  145.749 1.00 100.43 ? 138 PRO C C   1 
ATOM 3476 O O   . PRO C 1 138 ? -9.359  15.015  146.554 1.00 100.43 ? 138 PRO C O   1 
ATOM 3477 C CB  . PRO C 1 138 ? -10.571 12.674  144.896 1.00 100.43 ? 138 PRO C CB  1 
ATOM 3478 C CG  . PRO C 1 138 ? -11.318 11.628  145.621 1.00 100.43 ? 138 PRO C CG  1 
ATOM 3479 C CD  . PRO C 1 138 ? -10.862 11.698  147.042 1.00 100.43 ? 138 PRO C CD  1 
ATOM 3480 N N   . ILE C 1 139 ? -7.825  14.653  144.944 1.00 103.28 ? 139 ILE C N   1 
ATOM 3481 C CA  . ILE C 1 139 ? -7.336  16.026  144.913 1.00 103.28 ? 139 ILE C CA  1 
ATOM 3482 C C   . ILE C 1 139 ? -7.124  16.446  143.466 1.00 103.28 ? 139 ILE C C   1 
ATOM 3483 O O   . ILE C 1 139 ? -6.690  15.645  142.631 1.00 103.28 ? 139 ILE C O   1 
ATOM 3484 C CB  . ILE C 1 139 ? -6.035  16.187  145.724 1.00 103.28 ? 139 ILE C CB  1 
ATOM 3485 C CG1 . ILE C 1 139 ? -5.787  17.664  146.023 1.00 103.28 ? 139 ILE C CG1 1 
ATOM 3486 C CG2 . ILE C 1 139 ? -4.867  15.574  144.980 1.00 103.28 ? 139 ILE C CG2 1 
ATOM 3487 C CD1 . ILE C 1 139 ? -4.547  17.928  146.849 1.00 103.28 ? 139 ILE C CD1 1 
ATOM 3488 N N   . LEU C 1 140 ? -7.431  17.709  143.175 1.00 101.75 ? 140 LEU C N   1 
ATOM 3489 C CA  . LEU C 1 140 ? -7.129  18.305  141.880 1.00 101.75 ? 140 LEU C CA  1 
ATOM 3490 C C   . LEU C 1 140 ? -5.652  18.667  141.770 1.00 101.75 ? 140 LEU C C   1 
ATOM 3491 O O   . LEU C 1 140 ? -5.055  19.190  142.715 1.00 101.75 ? 140 LEU C O   1 
ATOM 3492 C CB  . LEU C 1 140 ? -7.977  19.559  141.663 1.00 101.75 ? 140 LEU C CB  1 
ATOM 3493 C CG  . LEU C 1 140 ? -9.472  19.346  141.425 1.00 101.75 ? 140 LEU C CG  1 
ATOM 3494 C CD1 . LEU C 1 140 ? -10.222 20.653  141.614 1.00 101.75 ? 140 LEU C CD1 1 
ATOM 3495 C CD2 . LEU C 1 140 ? -9.725  18.787  140.038 1.00 101.75 ? 140 LEU C CD2 1 
ATOM 3496 N N   . SER C 1 141 ? -5.064  18.393  140.606 1.00 111.80 ? 141 SER C N   1 
ATOM 3497 C CA  . SER C 1 141 ? -3.648  18.654  140.394 1.00 111.80 ? 141 SER C CA  1 
ATOM 3498 C C   . SER C 1 141 ? -3.418  19.008  138.932 1.00 111.80 ? 141 SER C C   1 
ATOM 3499 O O   . SER C 1 141 ? -4.226  18.680  138.060 1.00 111.80 ? 141 SER C O   1 
ATOM 3500 C CB  . SER C 1 141 ? -2.788  17.450  140.794 1.00 111.80 ? 141 SER C CB  1 
ATOM 3501 O OG  . SER C 1 141 ? -1.414  17.711  140.569 1.00 111.80 ? 141 SER C OG  1 
ATOM 3502 N N   . THR C 1 142 ? -2.296  19.684  138.675 1.00 118.05 ? 142 THR C N   1 
ATOM 3503 C CA  . THR C 1 142 ? -1.938  20.106  137.328 1.00 118.05 ? 142 THR C CA  1 
ATOM 3504 C C   . THR C 1 142 ? -0.536  19.693  136.897 1.00 118.05 ? 142 THR C C   1 
ATOM 3505 O O   . THR C 1 142 ? -0.117  20.064  135.796 1.00 118.05 ? 142 THR C O   1 
ATOM 3506 C CB  . THR C 1 142 ? -2.072  21.632  137.195 1.00 118.05 ? 142 THR C CB  1 
ATOM 3507 O OG1 . THR C 1 142 ? -1.875  22.014  135.829 1.00 118.05 ? 142 THR C OG1 1 
ATOM 3508 C CG2 . THR C 1 142 ? -1.057  22.350  138.076 1.00 118.05 ? 142 THR C CG2 1 
ATOM 3509 N N   . LEU C 1 143 ? 0.198   18.950  137.719 1.00 126.11 ? 143 LEU C N   1 
ATOM 3510 C CA  . LEU C 1 143 ? 1.462   18.388  137.267 1.00 126.11 ? 143 LEU C CA  1 
ATOM 3511 C C   . LEU C 1 143 ? 1.231   17.306  136.214 1.00 126.11 ? 143 LEU C C   1 
ATOM 3512 O O   . LEU C 1 143 ? 0.253   16.557  136.293 1.00 126.11 ? 143 LEU C O   1 
ATOM 3513 C CB  . LEU C 1 143 ? 2.237   17.800  138.444 1.00 126.11 ? 143 LEU C CB  1 
ATOM 3514 C CG  . LEU C 1 143 ? 2.879   18.802  139.404 1.00 126.11 ? 143 LEU C CG  1 
ATOM 3515 C CD1 . LEU C 1 143 ? 3.448   18.076  140.609 1.00 126.11 ? 143 LEU C CD1 1 
ATOM 3516 C CD2 . LEU C 1 143 ? 3.961   19.612  138.707 1.00 126.11 ? 143 LEU C CD2 1 
ATOM 3517 N N   . PRO C 1 144 ? 2.110   17.197  135.219 1.00 138.78 ? 144 PRO C N   1 
ATOM 3518 C CA  . PRO C 1 144 ? 2.019   16.086  134.270 1.00 138.78 ? 144 PRO C CA  1 
ATOM 3519 C C   . PRO C 1 144 ? 2.397   14.767  134.925 1.00 138.78 ? 144 PRO C C   1 
ATOM 3520 O O   . PRO C 1 144 ? 3.119   14.715  135.923 1.00 138.78 ? 144 PRO C O   1 
ATOM 3521 C CB  . PRO C 1 144 ? 3.016   16.473  133.174 1.00 138.78 ? 144 PRO C CB  1 
ATOM 3522 C CG  . PRO C 1 144 ? 4.048   17.253  133.895 1.00 138.78 ? 144 PRO C CG  1 
ATOM 3523 C CD  . PRO C 1 144 ? 3.294   18.033  134.953 1.00 138.78 ? 144 PRO C CD  1 
ATOM 3524 N N   . GLU C 1 145 ? 1.888   13.681  134.343 1.00 155.99 ? 145 GLU C N   1 
ATOM 3525 C CA  . GLU C 1 145 ? 2.119   12.355  134.901 1.00 155.99 ? 145 GLU C CA  1 
ATOM 3526 C C   . GLU C 1 145 ? 3.501   11.805  134.571 1.00 155.99 ? 145 GLU C C   1 
ATOM 3527 O O   . GLU C 1 145 ? 3.991   10.931  135.295 1.00 155.99 ? 145 GLU C O   1 
ATOM 3528 C CB  . GLU C 1 145 ? 1.054   11.380  134.396 1.00 155.99 ? 145 GLU C CB  1 
ATOM 3529 C CG  . GLU C 1 145 ? 1.167   9.986   134.985 1.00 155.99 ? 145 GLU C CG  1 
ATOM 3530 C CD  . GLU C 1 145 ? -0.133  9.212   134.904 1.00 155.99 ? 145 GLU C CD  1 
ATOM 3531 O OE1 . GLU C 1 145 ? -0.820  9.309   133.866 1.00 155.99 ? 145 GLU C OE1 1 
ATOM 3532 O OE2 . GLU C 1 145 ? -0.470  8.509   135.880 1.00 155.99 ? 145 GLU C OE2 1 
ATOM 3533 N N   . THR C 1 146 ? 4.137   12.285  133.507 1.00 155.90 ? 146 THR C N   1 
ATOM 3534 C CA  . THR C 1 146 ? 5.468   11.813  133.142 1.00 155.90 ? 146 THR C CA  1 
ATOM 3535 C C   . THR C 1 146 ? 6.493   12.229  134.192 1.00 155.90 ? 146 THR C C   1 
ATOM 3536 O O   . THR C 1 146 ? 7.457   11.509  134.451 1.00 155.90 ? 146 THR C O   1 
ATOM 3537 C CB  . THR C 1 146 ? 5.907   12.352  131.767 1.00 155.90 ? 146 THR C CB  1 
ATOM 3538 O OG1 . THR C 1 146 ? 5.894   13.785  131.781 1.00 155.90 ? 146 THR C OG1 1 
ATOM 3539 C CG2 . THR C 1 146 ? 4.982   11.843  130.671 1.00 155.90 ? 146 THR C CG2 1 
ATOM 3540 N N   . MET D 1 1   ? -6.283  45.025  144.885 1.00 111.57 ? 1   MET D N   1 
ATOM 3541 C CA  . MET D 1 1   ? -7.119  44.813  143.676 1.00 111.57 ? 1   MET D CA  1 
ATOM 3542 C C   . MET D 1 1   ? -8.127  45.957  143.566 1.00 111.57 ? 1   MET D C   1 
ATOM 3543 O O   . MET D 1 1   ? -8.918  46.120  144.507 1.00 111.57 ? 1   MET D O   1 
ATOM 3544 C CB  . MET D 1 1   ? -7.868  43.482  143.755 1.00 111.57 ? 1   MET D CB  1 
ATOM 3545 C CG  . MET D 1 1   ? -8.499  43.062  142.445 1.00 111.57 ? 1   MET D CG  1 
ATOM 3546 S SD  . MET D 1 1   ? -7.627  41.676  141.676 1.00 111.57 ? 1   MET D SD  1 
ATOM 3547 C CE  . MET D 1 1   ? -7.971  40.371  142.854 1.00 111.57 ? 1   MET D CE  1 
ATOM 3548 N N   . ASP D 1 2   ? -8.092  46.723  142.473 1.00 115.00 ? 2   ASP D N   1 
ATOM 3549 C CA  . ASP D 1 2   ? -9.008  47.873  142.250 1.00 115.00 ? 2   ASP D CA  1 
ATOM 3550 C C   . ASP D 1 2   ? -9.828  47.618  140.986 1.00 115.00 ? 2   ASP D C   1 
ATOM 3551 O O   . ASP D 1 2   ? -9.245  47.714  139.895 1.00 115.00 ? 2   ASP D O   1 
ATOM 3552 C CB  . ASP D 1 2   ? -8.223  49.178  142.145 1.00 115.00 ? 2   ASP D CB  1 
ATOM 3553 C CG  . ASP D 1 2   ? -9.100  50.411  142.029 1.00 115.00 ? 2   ASP D CG  1 
ATOM 3554 O OD1 . ASP D 1 2   ? -10.334 50.262  142.121 1.00 115.00 ? 2   ASP D OD1 1 
ATOM 3555 O OD2 . ASP D 1 2   ? -8.541  51.509  141.850 1.00 115.00 ? 2   ASP D OD2 1 
ATOM 3556 N N   . ILE D 1 3   ? -11.125 47.333  141.119 1.00 103.91 ? 3   ILE D N   1 
ATOM 3557 C CA  . ILE D 1 3   ? -12.002 47.001  139.960 1.00 103.91 ? 3   ILE D CA  1 
ATOM 3558 C C   . ILE D 1 3   ? -13.087 48.071  139.816 1.00 103.91 ? 3   ILE D C   1 
ATOM 3559 O O   . ILE D 1 3   ? -13.564 48.548  140.855 1.00 103.91 ? 3   ILE D O   1 
ATOM 3560 C CB  . ILE D 1 3   ? -12.604 45.593  140.131 1.00 103.91 ? 3   ILE D CB  1 
ATOM 3561 C CG1 . ILE D 1 3   ? -11.536 44.552  140.470 1.00 103.91 ? 3   ILE D CG1 1 
ATOM 3562 C CG2 . ILE D 1 3   ? -13.405 45.200  138.901 1.00 103.91 ? 3   ILE D CG2 1 
ATOM 3563 C CD1 . ILE D 1 3   ? -10.447 44.428  139.433 1.00 103.91 ? 3   ILE D CD1 1 
ATOM 3564 N N   . ASP D 1 4   ? -13.439 48.448  138.585 1.00 101.84 ? 4   ASP D N   1 
ATOM 3565 C CA  . ASP D 1 4   ? -14.508 49.442  138.297 1.00 101.84 ? 4   ASP D CA  1 
ATOM 3566 C C   . ASP D 1 4   ? -15.646 48.685  137.622 1.00 101.84 ? 4   ASP D C   1 
ATOM 3567 O O   . ASP D 1 4   ? -15.391 48.069  136.575 1.00 101.84 ? 4   ASP D O   1 
ATOM 3568 C CB  . ASP D 1 4   ? -13.974 50.581  137.429 1.00 101.84 ? 4   ASP D CB  1 
ATOM 3569 C CG  . ASP D 1 4   ? -15.022 51.575  136.962 1.00 101.84 ? 4   ASP D CG  1 
ATOM 3570 O OD1 . ASP D 1 4   ? -16.178 51.463  137.403 1.00 101.84 ? 4   ASP D OD1 1 
ATOM 3571 O OD2 . ASP D 1 4   ? -14.669 52.459  136.160 1.00 101.84 ? 4   ASP D OD2 1 
ATOM 3572 N N   . PRO D 1 5   ? -16.882 48.687  138.156 1.00 97.68  ? 5   PRO D N   1 
ATOM 3573 C CA  . PRO D 1 5   ? -17.962 47.854  137.600 1.00 97.68  ? 5   PRO D CA  1 
ATOM 3574 C C   . PRO D 1 5   ? -18.407 48.272  136.208 1.00 97.68  ? 5   PRO D C   1 
ATOM 3575 O O   . PRO D 1 5   ? -19.158 47.522  135.569 1.00 97.68  ? 5   PRO D O   1 
ATOM 3576 C CB  . PRO D 1 5   ? -19.102 48.036  138.612 1.00 97.68  ? 5   PRO D CB  1 
ATOM 3577 C CG  . PRO D 1 5   ? -18.823 49.347  139.256 1.00 97.68  ? 5   PRO D CG  1 
ATOM 3578 C CD  . PRO D 1 5   ? -17.330 49.436  139.340 1.00 97.68  ? 5   PRO D CD  1 
ATOM 3579 N N   . TYR D 1 6   ? -17.972 49.433  135.721 1.00 94.36  ? 6   TYR D N   1 
ATOM 3580 C CA  . TYR D 1 6   ? -18.395 49.968  134.432 1.00 94.36  ? 6   TYR D CA  1 
ATOM 3581 C C   . TYR D 1 6   ? -17.322 49.813  133.366 1.00 94.36  ? 6   TYR D C   1 
ATOM 3582 O O   . TYR D 1 6   ? -17.636 49.829  132.172 1.00 94.36  ? 6   TYR D O   1 
ATOM 3583 C CB  . TYR D 1 6   ? -18.767 51.447  134.578 1.00 94.36  ? 6   TYR D CB  1 
ATOM 3584 C CG  . TYR D 1 6   ? -19.864 51.672  135.591 1.00 94.36  ? 6   TYR D CG  1 
ATOM 3585 C CD1 . TYR D 1 6   ? -21.157 51.235  135.350 1.00 94.36  ? 6   TYR D CD1 1 
ATOM 3586 C CD2 . TYR D 1 6   ? -19.595 52.281  136.807 1.00 94.36  ? 6   TYR D CD2 1 
ATOM 3587 C CE1 . TYR D 1 6   ? -22.163 51.447  136.269 1.00 94.36  ? 6   TYR D CE1 1 
ATOM 3588 C CE2 . TYR D 1 6   ? -20.593 52.494  137.734 1.00 94.36  ? 6   TYR D CE2 1 
ATOM 3589 C CZ  . TYR D 1 6   ? -21.876 52.077  137.460 1.00 94.36  ? 6   TYR D CZ  1 
ATOM 3590 O OH  . TYR D 1 6   ? -22.864 52.252  138.400 1.00 94.36  ? 6   TYR D OH  1 
ATOM 3591 N N   . LYS D 1 7   ? -16.071 49.665  133.794 1.00 101.46 ? 7   LYS D N   1 
ATOM 3592 C CA  . LYS D 1 7   ? -14.912 49.774  132.917 1.00 101.46 ? 7   LYS D CA  1 
ATOM 3593 C C   . LYS D 1 7   ? -14.880 48.682  131.856 1.00 101.46 ? 7   LYS D C   1 
ATOM 3594 O O   . LYS D 1 7   ? -14.440 48.931  130.727 1.00 101.46 ? 7   LYS D O   1 
ATOM 3595 C CB  . LYS D 1 7   ? -13.666 49.772  133.811 1.00 101.46 ? 7   LYS D CB  1 
ATOM 3596 C CG  . LYS D 1 7   ? -12.337 50.157  133.202 1.00 101.46 ? 7   LYS D CG  1 
ATOM 3597 C CD  . LYS D 1 7   ? -11.608 48.918  132.708 1.00 101.46 ? 7   LYS D CD  1 
ATOM 3598 C CE  . LYS D 1 7   ? -10.234 49.258  132.167 1.00 101.46 ? 7   LYS D CE  1 
ATOM 3599 N NZ  . LYS D 1 7   ? -9.502  48.037  131.735 1.00 101.46 ? 7   LYS D NZ  1 
ATOM 3600 N N   . GLU D 1 8   ? -15.344 47.478  132.185 1.00 100.84 ? 8   GLU D N   1 
ATOM 3601 C CA  . GLU D 1 8   ? -15.505 46.443  131.170 1.00 100.84 ? 8   GLU D CA  1 
ATOM 3602 C C   . GLU D 1 8   ? -16.561 46.792  130.124 1.00 100.84 ? 8   GLU D C   1 
ATOM 3603 O O   . GLU D 1 8   ? -16.524 46.229  129.026 1.00 100.84 ? 8   GLU D O   1 
ATOM 3604 C CB  . GLU D 1 8   ? -15.846 45.121  131.859 1.00 100.84 ? 8   GLU D CB  1 
ATOM 3605 C CG  . GLU D 1 8   ? -16.682 44.151  131.045 1.00 100.84 ? 8   GLU D CG  1 
ATOM 3606 C CD  . GLU D 1 8   ? -17.017 42.888  131.813 1.00 100.84 ? 8   GLU D CD  1 
ATOM 3607 O OE1 . GLU D 1 8   ? -16.623 42.783  132.993 1.00 100.84 ? 8   GLU D OE1 1 
ATOM 3608 O OE2 . GLU D 1 8   ? -17.679 42.001  131.237 1.00 100.84 ? 8   GLU D OE2 1 
ATOM 3609 N N   . PHE D 1 9   ? -17.492 47.699  130.429 1.00 96.01  ? 9   PHE D N   1 
ATOM 3610 C CA  . PHE D 1 9   ? -18.479 48.176  129.464 1.00 96.01  ? 9   PHE D CA  1 
ATOM 3611 C C   . PHE D 1 9   ? -18.090 49.482  128.782 1.00 96.01  ? 9   PHE D C   1 
ATOM 3612 O O   . PHE D 1 9   ? -18.880 50.008  127.992 1.00 96.01  ? 9   PHE D O   1 
ATOM 3613 C CB  . PHE D 1 9   ? -19.851 48.318  130.131 1.00 96.01  ? 9   PHE D CB  1 
ATOM 3614 C CG  . PHE D 1 9   ? -20.341 47.053  130.772 1.00 96.01  ? 9   PHE D CG  1 
ATOM 3615 C CD1 . PHE D 1 9   ? -20.863 46.037  129.990 1.00 96.01  ? 9   PHE D CD1 1 
ATOM 3616 C CD2 . PHE D 1 9   ? -20.275 46.869  132.140 1.00 96.01  ? 9   PHE D CD2 1 
ATOM 3617 C CE1 . PHE D 1 9   ? -21.319 44.869  130.557 1.00 96.01  ? 9   PHE D CE1 1 
ATOM 3618 C CE2 . PHE D 1 9   ? -20.728 45.696  132.714 1.00 96.01  ? 9   PHE D CE2 1 
ATOM 3619 C CZ  . PHE D 1 9   ? -21.248 44.695  131.920 1.00 96.01  ? 9   PHE D CZ  1 
ATOM 3620 N N   . GLY D 1 10  ? -16.905 50.017  129.061 1.00 99.09  ? 10  GLY D N   1 
ATOM 3621 C CA  . GLY D 1 10  ? -16.415 51.184  128.360 1.00 99.09  ? 10  GLY D CA  1 
ATOM 3622 C C   . GLY D 1 10  ? -16.927 52.516  128.859 1.00 99.09  ? 10  GLY D C   1 
ATOM 3623 O O   . GLY D 1 10  ? -16.512 53.553  128.327 1.00 99.09  ? 10  GLY D O   1 
ATOM 3624 N N   . ALA D 1 11  ? -17.812 52.534  129.850 1.00 94.67  ? 11  ALA D N   1 
ATOM 3625 C CA  . ALA D 1 11  ? -18.079 53.749  130.598 1.00 94.67  ? 11  ALA D CA  1 
ATOM 3626 C C   . ALA D 1 11  ? -17.136 53.832  131.796 1.00 94.67  ? 11  ALA D C   1 
ATOM 3627 O O   . ALA D 1 11  ? -16.302 52.952  132.023 1.00 94.67  ? 11  ALA D O   1 
ATOM 3628 C CB  . ALA D 1 11  ? -19.540 53.792  131.041 1.00 94.67  ? 11  ALA D CB  1 
ATOM 3629 N N   . THR D 1 12  ? -17.262 54.904  132.574 1.00 97.92  ? 12  THR D N   1 
ATOM 3630 C CA  . THR D 1 12  ? -16.563 55.011  133.844 1.00 97.92  ? 12  THR D CA  1 
ATOM 3631 C C   . THR D 1 12  ? -17.527 55.536  134.897 1.00 97.92  ? 12  THR D C   1 
ATOM 3632 O O   . THR D 1 12  ? -18.552 56.146  134.583 1.00 97.92  ? 12  THR D O   1 
ATOM 3633 C CB  . THR D 1 12  ? -15.336 55.928  133.745 1.00 97.92  ? 12  THR D CB  1 
ATOM 3634 O OG1 . THR D 1 12  ? -15.758 57.294  133.656 1.00 97.92  ? 12  THR D OG1 1 
ATOM 3635 C CG2 . THR D 1 12  ? -14.508 55.582  132.518 1.00 97.92  ? 12  THR D CG2 1 
ATOM 3636 N N   . VAL D 1 13  ? -17.175 55.301  136.163 1.00 96.66  ? 13  VAL D N   1 
ATOM 3637 C CA  . VAL D 1 13  ? -17.910 55.901  137.273 1.00 96.66  ? 13  VAL D CA  1 
ATOM 3638 C C   . VAL D 1 13  ? -17.921 57.420  137.184 1.00 96.66  ? 13  VAL D C   1 
ATOM 3639 O O   . VAL D 1 13  ? -18.886 58.070  137.607 1.00 96.66  ? 13  VAL D O   1 
ATOM 3640 C CB  . VAL D 1 13  ? -17.304 55.427  138.609 1.00 96.66  ? 13  VAL D CB  1 
ATOM 3641 C CG1 . VAL D 1 13  ? -15.864 55.898  138.739 1.00 96.66  ? 13  VAL D CG1 1 
ATOM 3642 C CG2 . VAL D 1 13  ? -18.137 55.921  139.779 1.00 96.66  ? 13  VAL D CG2 1 
ATOM 3643 N N   . GLU D 1 14  ? -16.867 58.013  136.622 1.00 99.16  ? 14  GLU D N   1 
ATOM 3644 C CA  . GLU D 1 14  ? -16.824 59.466  136.487 1.00 99.16  ? 14  GLU D CA  1 
ATOM 3645 C C   . GLU D 1 14  ? -17.824 59.967  135.453 1.00 99.16  ? 14  GLU D C   1 
ATOM 3646 O O   . GLU D 1 14  ? -18.434 61.027  135.633 1.00 99.16  ? 14  GLU D O   1 
ATOM 3647 C CB  . GLU D 1 14  ? -15.411 59.908  136.111 1.00 99.16  ? 14  GLU D CB  1 
ATOM 3648 C CG  . GLU D 1 14  ? -14.351 59.562  137.144 1.00 99.16  ? 14  GLU D CG  1 
ATOM 3649 C CD  . GLU D 1 14  ? -13.855 58.132  137.021 1.00 99.16  ? 14  GLU D CD  1 
ATOM 3650 O OE1 . GLU D 1 14  ? -14.295 57.428  136.091 1.00 99.16  ? 14  GLU D OE1 1 
ATOM 3651 O OE2 . GLU D 1 14  ? -13.028 57.709  137.857 1.00 99.16  ? 14  GLU D OE2 1 
ATOM 3652 N N   . LEU D 1 15  ? -18.002 59.225  134.361 1.00 94.80  ? 15  LEU D N   1 
ATOM 3653 C CA  . LEU D 1 15  ? -19.015 59.585  133.375 1.00 94.80  ? 15  LEU D CA  1 
ATOM 3654 C C   . LEU D 1 15  ? -20.422 59.553  133.965 1.00 94.80  ? 15  LEU D C   1 
ATOM 3655 O O   . LEU D 1 15  ? -21.233 60.449  133.703 1.00 94.80  ? 15  LEU D O   1 
ATOM 3656 C CB  . LEU D 1 15  ? -18.906 58.644  132.178 1.00 94.80  ? 15  LEU D CB  1 
ATOM 3657 C CG  . LEU D 1 15  ? -19.864 58.883  131.017 1.00 94.80  ? 15  LEU D CG  1 
ATOM 3658 C CD1 . LEU D 1 15  ? -19.573 60.225  130.368 1.00 94.80  ? 15  LEU D CD1 1 
ATOM 3659 C CD2 . LEU D 1 15  ? -19.739 57.752  130.015 1.00 94.80  ? 15  LEU D CD2 1 
ATOM 3660 N N   . LEU D 1 16  ? -20.733 58.528  134.759 1.00 93.50  ? 16  LEU D N   1 
ATOM 3661 C CA  . LEU D 1 16  ? -22.020 58.476  135.453 1.00 93.50  ? 16  LEU D CA  1 
ATOM 3662 C C   . LEU D 1 16  ? -22.158 59.567  136.508 1.00 93.50  ? 16  LEU D C   1 
ATOM 3663 O O   . LEU D 1 16  ? -23.269 60.050  136.753 1.00 93.50  ? 16  LEU D O   1 
ATOM 3664 C CB  . LEU D 1 16  ? -22.221 57.104  136.093 1.00 93.50  ? 16  LEU D CB  1 
ATOM 3665 C CG  . LEU D 1 16  ? -22.626 55.975  135.141 1.00 93.50  ? 16  LEU D CG  1 
ATOM 3666 C CD1 . LEU D 1 16  ? -21.473 55.549  134.247 1.00 93.50  ? 16  LEU D CD1 1 
ATOM 3667 C CD2 . LEU D 1 16  ? -23.158 54.800  135.931 1.00 93.50  ? 16  LEU D CD2 1 
ATOM 3668 N N   . SER D 1 17  ? -21.056 59.964  137.140 1.00 93.85  ? 17  SER D N   1 
ATOM 3669 C CA  . SER D 1 17  ? -21.084 61.058  138.104 1.00 93.85  ? 17  SER D CA  1 
ATOM 3670 C C   . SER D 1 17  ? -21.711 62.338  137.560 1.00 93.85  ? 17  SER D C   1 
ATOM 3671 O O   . SER D 1 17  ? -22.174 63.167  138.350 1.00 93.85  ? 17  SER D O   1 
ATOM 3672 C CB  . SER D 1 17  ? -19.663 61.354  138.588 1.00 93.85  ? 17  SER D CB  1 
ATOM 3673 O OG  . SER D 1 17  ? -19.652 62.434  139.503 1.00 93.85  ? 17  SER D OG  1 
ATOM 3674 N N   . PHE D 1 18  ? -21.734 62.529  136.238 1.00 91.22  ? 18  PHE D N   1 
ATOM 3675 C CA  . PHE D 1 18  ? -22.473 63.655  135.671 1.00 91.22  ? 18  PHE D CA  1 
ATOM 3676 C C   . PHE D 1 18  ? -23.934 63.697  136.112 1.00 91.22  ? 18  PHE D C   1 
ATOM 3677 O O   . PHE D 1 18  ? -24.491 64.784  136.293 1.00 91.22  ? 18  PHE D O   1 
ATOM 3678 C CB  . PHE D 1 18  ? -22.430 63.591  134.140 1.00 91.22  ? 18  PHE D CB  1 
ATOM 3679 C CG  . PHE D 1 18  ? -21.074 63.861  133.540 1.00 91.22  ? 18  PHE D CG  1 
ATOM 3680 C CD1 . PHE D 1 18  ? -19.959 64.068  134.333 1.00 91.22  ? 18  PHE D CD1 1 
ATOM 3681 C CD2 . PHE D 1 18  ? -20.930 63.931  132.164 1.00 91.22  ? 18  PHE D CD2 1 
ATOM 3682 C CE1 . PHE D 1 18  ? -18.728 64.335  133.763 1.00 91.22  ? 18  PHE D CE1 1 
ATOM 3683 C CE2 . PHE D 1 18  ? -19.701 64.183  131.592 1.00 91.22  ? 18  PHE D CE2 1 
ATOM 3684 C CZ  . PHE D 1 18  ? -18.601 64.388  132.391 1.00 91.22  ? 18  PHE D CZ  1 
ATOM 3685 N N   . LEU D 1 19  ? -24.569 62.545  136.289 1.00 93.32  ? 19  LEU D N   1 
ATOM 3686 C CA  . LEU D 1 19  ? -25.946 62.519  136.788 1.00 93.32  ? 19  LEU D CA  1 
ATOM 3687 C C   . LEU D 1 19  ? -26.007 62.839  138.280 1.00 93.32  ? 19  LEU D C   1 
ATOM 3688 O O   . LEU D 1 19  ? -25.224 62.283  139.059 1.00 93.32  ? 19  LEU D O   1 
ATOM 3689 C CB  . LEU D 1 19  ? -26.583 61.160  136.517 1.00 93.32  ? 19  LEU D CB  1 
ATOM 3690 C CG  . LEU D 1 19  ? -26.600 60.725  135.052 1.00 93.32  ? 19  LEU D CG  1 
ATOM 3691 C CD1 . LEU D 1 19  ? -27.157 59.320  134.922 1.00 93.32  ? 19  LEU D CD1 1 
ATOM 3692 C CD2 . LEU D 1 19  ? -27.405 61.699  134.204 1.00 93.32  ? 19  LEU D CD2 1 
ATOM 3693 N N   . PRO D 1 20  ? -26.910 63.720  138.718 1.00 95.70  ? 20  PRO D N   1 
ATOM 3694 C CA  . PRO D 1 20  ? -27.041 63.980  140.156 1.00 95.70  ? 20  PRO D CA  1 
ATOM 3695 C C   . PRO D 1 20  ? -27.645 62.797  140.901 1.00 95.70  ? 20  PRO D C   1 
ATOM 3696 O O   . PRO D 1 20  ? -28.388 61.987  140.344 1.00 95.70  ? 20  PRO D O   1 
ATOM 3697 C CB  . PRO D 1 20  ? -27.957 65.207  140.212 1.00 95.70  ? 20  PRO D CB  1 
ATOM 3698 C CG  . PRO D 1 20  ? -28.790 65.097  138.995 1.00 95.70  ? 20  PRO D CG  1 
ATOM 3699 C CD  . PRO D 1 20  ? -27.918 64.458  137.939 1.00 95.70  ? 20  PRO D CD  1 
ATOM 3700 N N   . SER D 1 21  ? -27.308 62.717  142.192 1.00 100.75 ? 21  SER D N   1 
ATOM 3701 C CA  . SER D 1 21  ? -27.689 61.569  143.013 1.00 100.75 ? 21  SER D CA  1 
ATOM 3702 C C   . SER D 1 21  ? -29.199 61.362  143.118 1.00 100.75 ? 21  SER D C   1 
ATOM 3703 O O   . SER D 1 21  ? -29.650 60.221  143.270 1.00 100.75 ? 21  SER D O   1 
ATOM 3704 C CB  . SER D 1 21  ? -27.102 61.728  144.414 1.00 100.75 ? 21  SER D CB  1 
ATOM 3705 O OG  . SER D 1 21  ? -27.593 62.903  145.035 1.00 100.75 ? 21  SER D OG  1 
ATOM 3706 N N   . ASP D 1 22  ? -29.996 62.425  143.039 1.00 100.30 ? 22  ASP D N   1 
ATOM 3707 C CA  . ASP D 1 22  ? -31.451 62.298  143.083 1.00 100.30 ? 22  ASP D CA  1 
ATOM 3708 C C   . ASP D 1 22  ? -32.097 62.071  141.721 1.00 100.30 ? 22  ASP D C   1 
ATOM 3709 O O   . ASP D 1 22  ? -33.328 62.075  141.629 1.00 100.30 ? 22  ASP D O   1 
ATOM 3710 C CB  . ASP D 1 22  ? -32.061 63.540  143.744 1.00 100.30 ? 22  ASP D CB  1 
ATOM 3711 C CG  . ASP D 1 22  ? -31.812 64.813  142.954 1.00 100.30 ? 22  ASP D CG  1 
ATOM 3712 O OD1 . ASP D 1 22  ? -31.691 64.749  141.713 1.00 100.30 ? 22  ASP D OD1 1 
ATOM 3713 O OD2 . ASP D 1 22  ? -31.734 65.888  143.582 1.00 100.30 ? 22  ASP D OD2 1 
ATOM 3714 N N   . PHE D 1 23  ? -31.308 61.879  140.668 1.00 93.88  ? 23  PHE D N   1 
ATOM 3715 C CA  . PHE D 1 23  ? -31.881 61.591  139.357 1.00 93.88  ? 23  PHE D CA  1 
ATOM 3716 C C   . PHE D 1 23  ? -32.527 60.209  139.293 1.00 93.88  ? 23  PHE D C   1 
ATOM 3717 O O   . PHE D 1 23  ? -33.561 60.036  138.638 1.00 93.88  ? 23  PHE D O   1 
ATOM 3718 C CB  . PHE D 1 23  ? -30.802 61.725  138.285 1.00 93.88  ? 23  PHE D CB  1 
ATOM 3719 C CG  . PHE D 1 23  ? -31.281 61.404  136.902 1.00 93.88  ? 23  PHE D CG  1 
ATOM 3720 C CD1 . PHE D 1 23  ? -31.979 62.342  136.164 1.00 93.88  ? 23  PHE D CD1 1 
ATOM 3721 C CD2 . PHE D 1 23  ? -31.018 60.173  136.332 1.00 93.88  ? 23  PHE D CD2 1 
ATOM 3722 C CE1 . PHE D 1 23  ? -32.420 62.052  134.890 1.00 93.88  ? 23  PHE D CE1 1 
ATOM 3723 C CE2 . PHE D 1 23  ? -31.466 59.872  135.063 1.00 93.88  ? 23  PHE D CE2 1 
ATOM 3724 C CZ  . PHE D 1 23  ? -32.169 60.812  134.342 1.00 93.88  ? 23  PHE D CZ  1 
ATOM 3725 N N   . PHE D 1 24  ? -31.937 59.210  139.958 1.00 93.15  ? 24  PHE D N   1 
ATOM 3726 C CA  . PHE D 1 24  ? -32.322 57.823  139.703 1.00 93.15  ? 24  PHE D CA  1 
ATOM 3727 C C   . PHE D 1 24  ? -33.667 57.465  140.348 1.00 93.15  ? 24  PHE D C   1 
ATOM 3728 O O   . PHE D 1 24  ? -33.955 57.894  141.467 1.00 93.15  ? 24  PHE D O   1 
ATOM 3729 C CB  . PHE D 1 24  ? -31.231 56.891  140.211 1.00 93.15  ? 24  PHE D CB  1 
ATOM 3730 C CG  . PHE D 1 24  ? -29.886 57.173  139.608 1.00 93.15  ? 24  PHE D CG  1 
ATOM 3731 C CD1 . PHE D 1 24  ? -29.539 56.642  138.379 1.00 93.15  ? 24  PHE D CD1 1 
ATOM 3732 C CD2 . PHE D 1 24  ? -28.979 57.990  140.258 1.00 93.15  ? 24  PHE D CD2 1 
ATOM 3733 C CE1 . PHE D 1 24  ? -28.318 56.933  137.805 1.00 93.15  ? 24  PHE D CE1 1 
ATOM 3734 C CE2 . PHE D 1 24  ? -27.747 58.261  139.702 1.00 93.15  ? 24  PHE D CE2 1 
ATOM 3735 C CZ  . PHE D 1 24  ? -27.421 57.743  138.467 1.00 93.15  ? 24  PHE D CZ  1 
ATOM 3736 N N   . PRO D 1 25  ? -34.498 56.676  139.657 1.00 96.77  ? 25  PRO D N   1 
ATOM 3737 C CA  . PRO D 1 25  ? -35.740 56.159  140.251 1.00 96.77  ? 25  PRO D CA  1 
ATOM 3738 C C   . PRO D 1 25  ? -35.516 55.305  141.492 1.00 96.77  ? 25  PRO D C   1 
ATOM 3739 O O   . PRO D 1 25  ? -34.410 54.859  141.803 1.00 96.77  ? 25  PRO D O   1 
ATOM 3740 C CB  . PRO D 1 25  ? -36.353 55.328  139.119 1.00 96.77  ? 25  PRO D CB  1 
ATOM 3741 C CG  . PRO D 1 25  ? -35.799 55.914  137.886 1.00 96.77  ? 25  PRO D CG  1 
ATOM 3742 C CD  . PRO D 1 25  ? -34.392 56.289  138.241 1.00 96.77  ? 25  PRO D CD  1 
ATOM 3743 N N   . SER D 1 26  ? -36.617 55.083  142.208 1.00 100.50 ? 26  SER D N   1 
ATOM 3744 C CA  . SER D 1 26  ? -36.656 54.176  143.348 1.00 100.50 ? 26  SER D CA  1 
ATOM 3745 C C   . SER D 1 26  ? -36.464 52.716  142.927 1.00 100.50 ? 26  SER D C   1 
ATOM 3746 O O   . SER D 1 26  ? -36.740 52.314  141.794 1.00 100.50 ? 26  SER D O   1 
ATOM 3747 C CB  . SER D 1 26  ? -37.981 54.322  144.095 1.00 100.50 ? 26  SER D CB  1 
ATOM 3748 O OG  . SER D 1 26  ? -39.058 53.818  143.326 1.00 100.50 ? 26  SER D OG  1 
ATOM 3749 N N   . VAL D 1 27  ? -35.977 51.921  143.886 1.00 98.73  ? 27  VAL D N   1 
ATOM 3750 C CA  . VAL D 1 27  ? -35.709 50.496  143.681 1.00 98.73  ? 27  VAL D CA  1 
ATOM 3751 C C   . VAL D 1 27  ? -36.936 49.749  143.171 1.00 98.73  ? 27  VAL D C   1 
ATOM 3752 O O   . VAL D 1 27  ? -36.841 48.900  142.272 1.00 98.73  ? 27  VAL D O   1 
ATOM 3753 C CB  . VAL D 1 27  ? -35.195 49.864  144.990 1.00 98.73  ? 27  VAL D CB  1 
ATOM 3754 C CG1 . VAL D 1 27  ? -34.868 48.391  144.781 1.00 98.73  ? 27  VAL D CG1 1 
ATOM 3755 C CG2 . VAL D 1 27  ? -33.979 50.612  145.513 1.00 98.73  ? 27  VAL D CG2 1 
ATOM 3756 N N   . ARG D 1 28  ? -38.101 50.038  143.748 1.00 105.30 ? 28  ARG D N   1 
ATOM 3757 C CA  . ARG D 1 28  ? -39.330 49.354  143.360 1.00 105.30 ? 28  ARG D CA  1 
ATOM 3758 C C   . ARG D 1 28  ? -39.647 49.530  141.877 1.00 105.30 ? 28  ARG D C   1 
ATOM 3759 O O   . ARG D 1 28  ? -40.053 48.571  141.209 1.00 105.30 ? 28  ARG D O   1 
ATOM 3760 C CB  . ARG D 1 28  ? -40.474 49.886  144.227 1.00 105.30 ? 28  ARG D CB  1 
ATOM 3761 C CG  . ARG D 1 28  ? -41.848 49.245  144.045 1.00 105.30 ? 28  ARG D CG  1 
ATOM 3762 C CD  . ARG D 1 28  ? -41.895 47.787  144.511 1.00 105.30 ? 28  ARG D CD  1 
ATOM 3763 N NE  . ARG D 1 28  ? -41.566 46.828  143.463 1.00 105.30 ? 28  ARG D NE  1 
ATOM 3764 C CZ  . ARG D 1 28  ? -41.275 45.552  143.682 1.00 105.30 ? 28  ARG D CZ  1 
ATOM 3765 N NH1 . ARG D 1 28  ? -41.197 45.062  144.908 1.00 105.30 ? 28  ARG D NH1 1 
ATOM 3766 N NH2 . ARG D 1 28  ? -41.090 44.741  142.644 1.00 105.30 ? 28  ARG D NH2 1 
ATOM 3767 N N   . ASP D 1 29  ? -39.416 50.723  141.327 1.00 103.49 ? 29  ASP D N   1 
ATOM 3768 C CA  . ASP D 1 29  ? -39.712 50.948  139.914 1.00 103.49 ? 29  ASP D CA  1 
ATOM 3769 C C   . ASP D 1 29  ? -38.770 50.165  139.007 1.00 103.49 ? 29  ASP D C   1 
ATOM 3770 O O   . ASP D 1 29  ? -39.202 49.569  138.012 1.00 103.49 ? 29  ASP D O   1 
ATOM 3771 C CB  . ASP D 1 29  ? -39.624 52.441  139.599 1.00 103.49 ? 29  ASP D CB  1 
ATOM 3772 C CG  . ASP D 1 29  ? -40.658 53.254  140.346 1.00 103.49 ? 29  ASP D CG  1 
ATOM 3773 O OD1 . ASP D 1 29  ? -41.756 52.723  140.614 1.00 103.49 ? 29  ASP D OD1 1 
ATOM 3774 O OD2 . ASP D 1 29  ? -40.373 54.427  140.669 1.00 103.49 ? 29  ASP D OD2 1 
ATOM 3775 N N   . LEU D 1 30  ? -37.489 50.111  139.363 1.00 97.06  ? 30  LEU D N   1 
ATOM 3776 C CA  . LEU D 1 30  ? -36.516 49.376  138.561 1.00 97.06  ? 30  LEU D CA  1 
ATOM 3777 C C   . LEU D 1 30  ? -36.773 47.876  138.606 1.00 97.06  ? 30  LEU D C   1 
ATOM 3778 O O   . LEU D 1 30  ? -36.725 47.193  137.574 1.00 97.06  ? 30  LEU D O   1 
ATOM 3779 C CB  . LEU D 1 30  ? -35.104 49.702  139.049 1.00 97.06  ? 30  LEU D CB  1 
ATOM 3780 C CG  . LEU D 1 30  ? -34.700 51.170  138.888 1.00 97.06  ? 30  LEU D CG  1 
ATOM 3781 C CD1 . LEU D 1 30  ? -33.427 51.465  139.661 1.00 97.06  ? 30  LEU D CD1 1 
ATOM 3782 C CD2 . LEU D 1 30  ? -34.529 51.526  137.420 1.00 97.06  ? 30  LEU D CD2 1 
ATOM 3783 N N   . LEU D 1 31  ? -37.040 47.339  139.796 1.00 98.63  ? 31  LEU D N   1 
ATOM 3784 C CA  . LEU D 1 31  ? -37.389 45.926  139.902 1.00 98.63  ? 31  LEU D CA  1 
ATOM 3785 C C   . LEU D 1 31  ? -38.678 45.597  139.159 1.00 98.63  ? 31  LEU D C   1 
ATOM 3786 O O   . LEU D 1 31  ? -38.768 44.553  138.505 1.00 98.63  ? 31  LEU D O   1 
ATOM 3787 C CB  . LEU D 1 31  ? -37.502 45.523  141.371 1.00 98.63  ? 31  LEU D CB  1 
ATOM 3788 C CG  . LEU D 1 31  ? -36.187 45.489  142.155 1.00 98.63  ? 31  LEU D CG  1 
ATOM 3789 C CD1 . LEU D 1 31  ? -36.441 45.165  143.619 1.00 98.63  ? 31  LEU D CD1 1 
ATOM 3790 C CD2 . LEU D 1 31  ? -35.206 44.490  141.551 1.00 98.63  ? 31  LEU D CD2 1 
ATOM 3791 N N   . ASP D 1 32  ? -39.694 46.457  139.251 1.00 103.66 ? 32  ASP D N   1 
ATOM 3792 C CA  . ASP D 1 32  ? -40.897 46.247  138.449 1.00 103.66 ? 32  ASP D CA  1 
ATOM 3793 C C   . ASP D 1 32  ? -40.600 46.223  136.955 1.00 103.66 ? 32  ASP D C   1 
ATOM 3794 O O   . ASP D 1 32  ? -41.138 45.382  136.224 1.00 103.66 ? 32  ASP D O   1 
ATOM 3795 C CB  . ASP D 1 32  ? -41.930 47.326  138.765 1.00 103.66 ? 32  ASP D CB  1 
ATOM 3796 C CG  . ASP D 1 32  ? -42.462 47.218  140.172 1.00 103.66 ? 32  ASP D CG  1 
ATOM 3797 O OD1 . ASP D 1 32  ? -41.983 46.342  140.920 1.00 103.66 ? 32  ASP D OD1 1 
ATOM 3798 O OD2 . ASP D 1 32  ? -43.354 48.013  140.532 1.00 103.66 ? 32  ASP D OD2 1 
ATOM 3799 N N   . THR D 1 33  ? -39.741 47.125  136.479 1.00 99.85  ? 33  THR D N   1 
ATOM 3800 C CA  . THR D 1 33  ? -39.409 47.139  135.055 1.00 99.85  ? 33  THR D CA  1 
ATOM 3801 C C   . THR D 1 33  ? -38.676 45.870  134.633 1.00 99.85  ? 33  THR D C   1 
ATOM 3802 O O   . THR D 1 33  ? -38.977 45.290  133.579 1.00 99.85  ? 33  THR D O   1 
ATOM 3803 C CB  . THR D 1 33  ? -38.563 48.369  134.733 1.00 99.85  ? 33  THR D CB  1 
ATOM 3804 O OG1 . THR D 1 33  ? -39.250 49.550  135.165 1.00 99.85  ? 33  THR D OG1 1 
ATOM 3805 C CG2 . THR D 1 33  ? -38.295 48.463  133.238 1.00 99.85  ? 33  THR D CG2 1 
ATOM 3806 N N   . ALA D 1 34  ? -37.711 45.427  135.439 1.00 99.38  ? 34  ALA D N   1 
ATOM 3807 C CA  . ALA D 1 34  ? -37.014 44.176  135.153 1.00 99.38  ? 34  ALA D CA  1 
ATOM 3808 C C   . ALA D 1 34  ? -37.964 42.985  135.148 1.00 99.38  ? 34  ALA D C   1 
ATOM 3809 O O   . ALA D 1 34  ? -37.917 42.146  134.239 1.00 99.38  ? 34  ALA D O   1 
ATOM 3810 C CB  . ALA D 1 34  ? -35.898 43.960  136.174 1.00 99.38  ? 34  ALA D CB  1 
ATOM 3811 N N   . SER D 1 35  ? -38.863 42.916  136.130 1.00 104.86 ? 35  SER D N   1 
ATOM 3812 C CA  . SER D 1 35  ? -39.866 41.857  136.161 1.00 104.86 ? 35  SER D CA  1 
ATOM 3813 C C   . SER D 1 35  ? -40.744 41.871  134.919 1.00 104.86 ? 35  SER D C   1 
ATOM 3814 O O   . SER D 1 35  ? -41.046 40.816  134.349 1.00 104.86 ? 35  SER D O   1 
ATOM 3815 C CB  . SER D 1 35  ? -40.730 42.011  137.410 1.00 104.86 ? 35  SER D CB  1 
ATOM 3816 O OG  . SER D 1 35  ? -41.734 41.016  137.473 1.00 104.86 ? 35  SER D OG  1 
ATOM 3817 N N   . ALA D 1 36  ? -41.161 43.055  134.482 1.00 99.76  ? 36  ALA D N   1 
ATOM 3818 C CA  . ALA D 1 36  ? -41.998 43.154  133.293 1.00 99.76  ? 36  ALA D CA  1 
ATOM 3819 C C   . ALA D 1 36  ? -41.268 42.692  132.036 1.00 99.76  ? 36  ALA D C   1 
ATOM 3820 O O   . ALA D 1 36  ? -41.824 41.936  131.231 1.00 99.76  ? 36  ALA D O   1 
ATOM 3821 C CB  . ALA D 1 36  ? -42.489 44.591  133.126 1.00 99.76  ? 36  ALA D CB  1 
ATOM 3822 N N   . LEU D 1 37  ? -40.023 43.128  131.846 1.00 100.74 ? 37  LEU D N   1 
ATOM 3823 C CA  . LEU D 1 37  ? -39.377 42.925  130.550 1.00 100.74 ? 37  LEU D CA  1 
ATOM 3824 C C   . LEU D 1 37  ? -38.511 41.670  130.423 1.00 100.74 ? 37  LEU D C   1 
ATOM 3825 O O   . LEU D 1 37  ? -38.479 41.074  129.340 1.00 100.74 ? 37  LEU D O   1 
ATOM 3826 C CB  . LEU D 1 37  ? -38.529 44.151  130.195 1.00 100.74 ? 37  LEU D CB  1 
ATOM 3827 C CG  . LEU D 1 37  ? -39.279 45.471  129.964 1.00 100.74 ? 37  LEU D CG  1 
ATOM 3828 C CD1 . LEU D 1 37  ? -38.297 46.629  129.766 1.00 100.74 ? 37  LEU D CD1 1 
ATOM 3829 C CD2 . LEU D 1 37  ? -40.246 45.383  128.795 1.00 100.74 ? 37  LEU D CD2 1 
ATOM 3830 N N   . TYR D 1 38  ? -37.809 41.231  131.472 1.00 100.71 ? 38  TYR D N   1 
ATOM 3831 C CA  . TYR D 1 38  ? -36.666 40.342  131.288 1.00 100.71 ? 38  TYR D CA  1 
ATOM 3832 C C   . TYR D 1 38  ? -36.676 39.055  132.107 1.00 100.71 ? 38  TYR D C   1 
ATOM 3833 O O   . TYR D 1 38  ? -35.663 38.342  132.101 1.00 100.71 ? 38  TYR D O   1 
ATOM 3834 C CB  . TYR D 1 38  ? -35.373 41.122  131.567 1.00 100.71 ? 38  TYR D CB  1 
ATOM 3835 C CG  . TYR D 1 38  ? -35.188 42.266  130.595 1.00 100.71 ? 38  TYR D CG  1 
ATOM 3836 C CD1 . TYR D 1 38  ? -35.067 42.027  129.233 1.00 100.71 ? 38  TYR D CD1 1 
ATOM 3837 C CD2 . TYR D 1 38  ? -35.145 43.581  131.035 1.00 100.71 ? 38  TYR D CD2 1 
ATOM 3838 C CE1 . TYR D 1 38  ? -34.896 43.061  128.338 1.00 100.71 ? 38  TYR D CE1 1 
ATOM 3839 C CE2 . TYR D 1 38  ? -34.974 44.624  130.145 1.00 100.71 ? 38  TYR D CE2 1 
ATOM 3840 C CZ  . TYR D 1 38  ? -34.857 44.359  128.798 1.00 100.71 ? 38  TYR D CZ  1 
ATOM 3841 O OH  . TYR D 1 38  ? -34.704 45.394  127.905 1.00 100.71 ? 38  TYR D OH  1 
ATOM 3842 N N   . ARG D 1 39  ? -37.744 38.777  132.860 1.00 107.09 ? 39  ARG D N   1 
ATOM 3843 C CA  . ARG D 1 39  ? -37.760 37.635  133.772 1.00 107.09 ? 39  ARG D CA  1 
ATOM 3844 C C   . ARG D 1 39  ? -37.392 36.329  133.071 1.00 107.09 ? 39  ARG D C   1 
ATOM 3845 O O   . ARG D 1 39  ? -36.569 35.552  133.568 1.00 107.09 ? 39  ARG D O   1 
ATOM 3846 C CB  . ARG D 1 39  ? -39.156 37.499  134.383 1.00 107.09 ? 39  ARG D CB  1 
ATOM 3847 C CG  . ARG D 1 39  ? -39.292 36.372  135.388 1.00 107.09 ? 39  ARG D CG  1 
ATOM 3848 C CD  . ARG D 1 39  ? -40.665 36.360  136.047 1.00 107.09 ? 39  ARG D CD  1 
ATOM 3849 N NE  . ARG D 1 39  ? -40.910 37.499  136.922 1.00 107.09 ? 39  ARG D NE  1 
ATOM 3850 C CZ  . ARG D 1 39  ? -42.064 37.725  137.538 1.00 107.09 ? 39  ARG D CZ  1 
ATOM 3851 N NH1 . ARG D 1 39  ? -43.128 36.970  137.314 1.00 107.09 ? 39  ARG D NH1 1 
ATOM 3852 N NH2 . ARG D 1 39  ? -42.159 38.746  138.383 1.00 107.09 ? 39  ARG D NH2 1 
ATOM 3853 N N   . GLU D 1 40  ? -38.006 36.067  131.915 1.00 110.01 ? 40  GLU D N   1 
ATOM 3854 C CA  . GLU D 1 40  ? -37.800 34.788  131.237 1.00 110.01 ? 40  GLU D CA  1 
ATOM 3855 C C   . GLU D 1 40  ? -36.373 34.626  130.719 1.00 110.01 ? 40  GLU D C   1 
ATOM 3856 O O   . GLU D 1 40  ? -35.821 33.520  130.758 1.00 110.01 ? 40  GLU D O   1 
ATOM 3857 C CB  . GLU D 1 40  ? -38.817 34.630  130.101 1.00 110.01 ? 40  GLU D CB  1 
ATOM 3858 C CG  . GLU D 1 40  ? -38.410 35.225  128.756 1.00 110.01 ? 40  GLU D CG  1 
ATOM 3859 C CD  . GLU D 1 40  ? -38.199 36.723  128.817 1.00 110.01 ? 40  GLU D CD  1 
ATOM 3860 O OE1 . GLU D 1 40  ? -37.625 37.285  127.859 1.00 110.01 ? 40  GLU D OE1 1 
ATOM 3861 O OE2 . GLU D 1 40  ? -38.610 37.341  129.821 1.00 110.01 ? 40  GLU D OE2 1 
ATOM 3862 N N   . ALA D 1 41  ? -35.757 35.704  130.237 1.00 102.81 ? 41  ALA D N   1 
ATOM 3863 C CA  . ALA D 1 41  ? -34.343 35.648  129.879 1.00 102.81 ? 41  ALA D CA  1 
ATOM 3864 C C   . ALA D 1 41  ? -33.459 35.418  131.098 1.00 102.81 ? 41  ALA D C   1 
ATOM 3865 O O   . ALA D 1 41  ? -32.580 34.550  131.083 1.00 102.81 ? 41  ALA D O   1 
ATOM 3866 C CB  . ALA D 1 41  ? -33.937 36.934  129.160 1.00 102.81 ? 41  ALA D CB  1 
ATOM 3867 N N   . LEU D 1 42  ? -33.676 36.185  132.165 1.00 100.66 ? 42  LEU D N   1 
ATOM 3868 C CA  . LEU D 1 42  ? -32.820 36.062  133.342 1.00 100.66 ? 42  LEU D CA  1 
ATOM 3869 C C   . LEU D 1 42  ? -32.893 34.665  133.953 1.00 100.66 ? 42  LEU D C   1 
ATOM 3870 O O   . LEU D 1 42  ? -31.869 34.105  134.359 1.00 100.66 ? 42  LEU D O   1 
ATOM 3871 C CB  . LEU D 1 42  ? -33.204 37.124  134.371 1.00 100.66 ? 42  LEU D CB  1 
ATOM 3872 C CG  . LEU D 1 42  ? -32.826 38.557  133.986 1.00 100.66 ? 42  LEU D CG  1 
ATOM 3873 C CD1 . LEU D 1 42  ? -33.501 39.556  134.904 1.00 100.66 ? 42  LEU D CD1 1 
ATOM 3874 C CD2 . LEU D 1 42  ? -31.318 38.758  134.010 1.00 100.66 ? 42  LEU D CD2 1 
ATOM 3875 N N   . GLU D 1 43  ? -34.092 34.088  134.024 1.00 106.29 ? 43  GLU D N   1 
ATOM 3876 C CA  . GLU D 1 43  ? -34.240 32.710  134.490 1.00 106.29 ? 43  GLU D CA  1 
ATOM 3877 C C   . GLU D 1 43  ? -33.664 31.685  133.513 1.00 106.29 ? 43  GLU D C   1 
ATOM 3878 O O   . GLU D 1 43  ? -33.224 30.611  133.939 1.00 106.29 ? 43  GLU D O   1 
ATOM 3879 C CB  . GLU D 1 43  ? -35.712 32.416  134.769 1.00 106.29 ? 43  GLU D CB  1 
ATOM 3880 C CG  . GLU D 1 43  ? -36.273 33.225  135.932 1.00 106.29 ? 43  GLU D CG  1 
ATOM 3881 C CD  . GLU D 1 43  ? -37.710 32.874  136.253 1.00 106.29 ? 43  GLU D CD  1 
ATOM 3882 O OE1 . GLU D 1 43  ? -38.143 33.128  137.397 1.00 106.29 ? 43  GLU D OE1 1 
ATOM 3883 O OE2 . GLU D 1 43  ? -38.409 32.350  135.361 1.00 106.29 ? 43  GLU D OE2 1 
ATOM 3884 N N   . SER D 1 44  ? -33.657 31.987  132.218 1.00 107.12 ? 44  SER D N   1 
ATOM 3885 C CA  . SER D 1 44  ? -33.280 31.008  131.205 1.00 107.12 ? 44  SER D CA  1 
ATOM 3886 C C   . SER D 1 44  ? -31.859 30.473  131.424 1.00 107.12 ? 44  SER D C   1 
ATOM 3887 O O   . SER D 1 44  ? -31.000 31.166  131.976 1.00 107.12 ? 44  SER D O   1 
ATOM 3888 C CB  . SER D 1 44  ? -33.391 31.644  129.822 1.00 107.12 ? 44  SER D CB  1 
ATOM 3889 O OG  . SER D 1 44  ? -33.006 30.748  128.800 1.00 107.12 ? 44  SER D OG  1 
ATOM 3890 N N   . PRO D 1 45  ? -31.589 29.210  131.000 1.00 104.29 ? 45  PRO D N   1 
ATOM 3891 C CA  . PRO D 1 45  ? -30.266 28.599  131.212 1.00 104.29 ? 45  PRO D CA  1 
ATOM 3892 C C   . PRO D 1 45  ? -29.160 29.048  130.268 1.00 104.29 ? 45  PRO D C   1 
ATOM 3893 O O   . PRO D 1 45  ? -28.234 28.276  130.002 1.00 104.29 ? 45  PRO D O   1 
ATOM 3894 C CB  . PRO D 1 45  ? -30.557 27.103  131.020 1.00 104.29 ? 45  PRO D CB  1 
ATOM 3895 C CG  . PRO D 1 45  ? -31.596 27.094  129.977 1.00 104.29 ? 45  PRO D CG  1 
ATOM 3896 C CD  . PRO D 1 45  ? -32.508 28.250  130.358 1.00 104.29 ? 45  PRO D CD  1 
ATOM 3897 N N   . GLU D 1 46  ? -29.220 30.275  129.760 1.00 108.24 ? 46  GLU D N   1 
ATOM 3898 C CA  . GLU D 1 46  ? -28.243 30.752  128.792 1.00 108.24 ? 46  GLU D CA  1 
ATOM 3899 C C   . GLU D 1 46  ? -27.639 32.062  129.267 1.00 108.24 ? 46  GLU D C   1 
ATOM 3900 O O   . GLU D 1 46  ? -28.334 32.913  129.832 1.00 108.24 ? 46  GLU D O   1 
ATOM 3901 C CB  . GLU D 1 46  ? -28.875 30.938  127.409 1.00 108.24 ? 46  GLU D CB  1 
ATOM 3902 C CG  . GLU D 1 46  ? -29.312 29.638  126.753 1.00 108.24 ? 46  GLU D CG  1 
ATOM 3903 C CD  . GLU D 1 46  ? -29.999 29.854  125.420 1.00 108.24 ? 46  GLU D CD  1 
ATOM 3904 O OE1 . GLU D 1 46  ? -30.305 31.017  125.091 1.00 108.24 ? 46  GLU D OE1 1 
ATOM 3905 O OE2 . GLU D 1 46  ? -30.225 28.860  124.698 1.00 108.24 ? 46  GLU D OE2 1 
ATOM 3906 N N   . HIS D 1 47  ? -26.333 32.214  129.036 1.00 108.35 ? 47  HIS D N   1 
ATOM 3907 C CA  . HIS D 1 47  ? -25.645 33.491  129.223 1.00 108.35 ? 47  HIS D CA  1 
ATOM 3908 C C   . HIS D 1 47  ? -25.907 34.391  128.014 1.00 108.35 ? 47  HIS D C   1 
ATOM 3909 O O   . HIS D 1 47  ? -25.058 34.621  127.151 1.00 108.35 ? 47  HIS D O   1 
ATOM 3910 C CB  . HIS D 1 47  ? -24.157 33.254  129.466 1.00 108.35 ? 47  HIS D CB  1 
ATOM 3911 C CG  . HIS D 1 47  ? -23.412 32.720  128.281 1.00 108.35 ? 47  HIS D CG  1 
ATOM 3912 N ND1 . HIS D 1 47  ? -23.427 31.385  127.936 1.00 108.35 ? 47  HIS D ND1 1 
ATOM 3913 C CD2 . HIS D 1 47  ? -22.610 33.333  127.378 1.00 108.35 ? 47  HIS D CD2 1 
ATOM 3914 C CE1 . HIS D 1 47  ? -22.679 31.201  126.863 1.00 108.35 ? 47  HIS D CE1 1 
ATOM 3915 N NE2 . HIS D 1 47  ? -22.173 32.367  126.503 1.00 108.35 ? 47  HIS D NE2 1 
ATOM 3916 N N   . CYS D 1 48  ? -27.135 34.912  127.966 1.00 105.11 ? 48  CYS D N   1 
ATOM 3917 C CA  . CYS D 1 48  ? -27.559 35.669  126.795 1.00 105.11 ? 48  CYS D CA  1 
ATOM 3918 C C   . CYS D 1 48  ? -26.636 36.852  126.533 1.00 105.11 ? 48  CYS D C   1 
ATOM 3919 O O   . CYS D 1 48  ? -26.297 37.136  125.379 1.00 105.11 ? 48  CYS D O   1 
ATOM 3920 C CB  . CYS D 1 48  ? -29.001 36.141  126.977 1.00 105.11 ? 48  CYS D CB  1 
ATOM 3921 S SG  . CYS D 1 48  ? -30.207 34.802  127.128 1.00 105.11 ? 48  CYS D SG  1 
ATOM 3922 N N   . SER D 1 49  ? -26.210 37.552  127.582 1.00 101.40 ? 49  SER D N   1 
ATOM 3923 C CA  . SER D 1 49  ? -25.203 38.593  127.427 1.00 101.40 ? 49  SER D CA  1 
ATOM 3924 C C   . SER D 1 49  ? -24.612 38.911  128.794 1.00 101.40 ? 49  SER D C   1 
ATOM 3925 O O   . SER D 1 49  ? -25.177 38.534  129.830 1.00 101.40 ? 49  SER D O   1 
ATOM 3926 C CB  . SER D 1 49  ? -25.800 39.854  126.779 1.00 101.40 ? 49  SER D CB  1 
ATOM 3927 O OG  . SER D 1 49  ? -26.868 40.365  127.554 1.00 101.40 ? 49  SER D OG  1 
ATOM 3928 N N   . PRO D 1 50  ? -23.473 39.607  128.828 1.00 96.24  ? 50  PRO D N   1 
ATOM 3929 C CA  . PRO D 1 50  ? -22.886 40.040  130.111 1.00 96.24  ? 50  PRO D CA  1 
ATOM 3930 C C   . PRO D 1 50  ? -23.812 40.872  130.986 1.00 96.24  ? 50  PRO D C   1 
ATOM 3931 O O   . PRO D 1 50  ? -23.704 40.824  132.221 1.00 96.24  ? 50  PRO D O   1 
ATOM 3932 C CB  . PRO D 1 50  ? -21.661 40.855  129.669 1.00 96.24  ? 50  PRO D CB  1 
ATOM 3933 C CG  . PRO D 1 50  ? -21.307 40.304  128.335 1.00 96.24  ? 50  PRO D CG  1 
ATOM 3934 C CD  . PRO D 1 50  ? -22.624 39.990  127.690 1.00 96.24  ? 50  PRO D CD  1 
ATOM 3935 N N   . HIS D 1 51  ? -24.746 41.606  130.381 1.00 93.74  ? 51  HIS D N   1 
ATOM 3936 C CA  . HIS D 1 51  ? -25.706 42.386  131.155 1.00 93.74  ? 51  HIS D CA  1 
ATOM 3937 C C   . HIS D 1 51  ? -26.604 41.495  132.001 1.00 93.74  ? 51  HIS D C   1 
ATOM 3938 O O   . HIS D 1 51  ? -26.895 41.820  133.159 1.00 93.74  ? 51  HIS D O   1 
ATOM 3939 C CB  . HIS D 1 51  ? -26.562 43.234  130.214 1.00 93.74  ? 51  HIS D CB  1 
ATOM 3940 C CG  . HIS D 1 51  ? -25.781 44.199  129.378 1.00 93.74  ? 51  HIS D CG  1 
ATOM 3941 N ND1 . HIS D 1 51  ? -25.318 45.403  129.863 1.00 93.74  ? 51  HIS D ND1 1 
ATOM 3942 C CD2 . HIS D 1 51  ? -25.403 44.147  128.079 1.00 93.74  ? 51  HIS D CD2 1 
ATOM 3943 C CE1 . HIS D 1 51  ? -24.675 46.044  128.903 1.00 93.74  ? 51  HIS D CE1 1 
ATOM 3944 N NE2 . HIS D 1 51  ? -24.727 45.310  127.806 1.00 93.74  ? 51  HIS D NE2 1 
ATOM 3945 N N   . HIS D 1 52  ? -27.039 40.364  131.453 1.00 96.52  ? 52  HIS D N   1 
ATOM 3946 C CA  . HIS D 1 52  ? -27.870 39.448  132.225 1.00 96.52  ? 52  HIS D CA  1 
ATOM 3947 C C   . HIS D 1 52  ? -27.110 38.859  133.409 1.00 96.52  ? 52  HIS D C   1 
ATOM 3948 O O   . HIS D 1 52  ? -27.655 38.762  134.513 1.00 96.52  ? 52  HIS D O   1 
ATOM 3949 C CB  . HIS D 1 52  ? -28.385 38.333  131.317 1.00 96.52  ? 52  HIS D CB  1 
ATOM 3950 C CG  . HIS D 1 52  ? -29.233 38.818  130.182 1.00 96.52  ? 52  HIS D CG  1 
ATOM 3951 N ND1 . HIS D 1 52  ? -28.706 39.161  128.956 1.00 96.52  ? 52  HIS D ND1 1 
ATOM 3952 C CD2 . HIS D 1 52  ? -30.569 39.012  130.084 1.00 96.52  ? 52  HIS D CD2 1 
ATOM 3953 C CE1 . HIS D 1 52  ? -29.679 39.550  128.153 1.00 96.52  ? 52  HIS D CE1 1 
ATOM 3954 N NE2 . HIS D 1 52  ? -30.822 39.460  128.810 1.00 96.52  ? 52  HIS D NE2 1 
ATOM 3955 N N   . THR D 1 53  ? -25.855 38.460  133.201 1.00 94.32  ? 53  THR D N   1 
ATOM 3956 C CA  . THR D 1 53  ? -25.023 37.977  134.302 1.00 94.32  ? 53  THR D CA  1 
ATOM 3957 C C   . THR D 1 53  ? -24.843 39.026  135.401 1.00 94.32  ? 53  THR D C   1 
ATOM 3958 O O   . THR D 1 53  ? -24.990 38.727  136.597 1.00 94.32  ? 53  THR D O   1 
ATOM 3959 C CB  . THR D 1 53  ? -23.660 37.549  133.752 1.00 94.32  ? 53  THR D CB  1 
ATOM 3960 O OG1 . THR D 1 53  ? -23.839 36.539  132.752 1.00 94.32  ? 53  THR D OG1 1 
ATOM 3961 C CG2 . THR D 1 53  ? -22.769 37.004  134.857 1.00 94.32  ? 53  THR D CG2 1 
ATOM 3962 N N   . ALA D 1 54  ? -24.548 40.270  135.016 1.00 94.38  ? 54  ALA D N   1 
ATOM 3963 C CA  . ALA D 1 54  ? -24.413 41.331  136.012 1.00 94.38  ? 54  ALA D CA  1 
ATOM 3964 C C   . ALA D 1 54  ? -25.709 41.577  136.779 1.00 94.38  ? 54  ALA D C   1 
ATOM 3965 O O   . ALA D 1 54  ? -25.696 41.710  138.012 1.00 94.38  ? 54  ALA D O   1 
ATOM 3966 C CB  . ALA D 1 54  ? -23.947 42.618  135.334 1.00 94.38  ? 54  ALA D CB  1 
ATOM 3967 N N   . LEU D 1 55  ? -26.839 41.632  136.074 1.00 94.43  ? 55  LEU D N   1 
ATOM 3968 C CA  . LEU D 1 55  ? -28.123 41.787  136.750 1.00 94.43  ? 55  LEU D CA  1 
ATOM 3969 C C   . LEU D 1 55  ? -28.397 40.639  137.716 1.00 94.43  ? 55  LEU D C   1 
ATOM 3970 O O   . LEU D 1 55  ? -28.875 40.861  138.835 1.00 94.43  ? 55  LEU D O   1 
ATOM 3971 C CB  . LEU D 1 55  ? -29.238 41.891  135.709 1.00 94.43  ? 55  LEU D CB  1 
ATOM 3972 C CG  . LEU D 1 55  ? -29.345 43.231  134.973 1.00 94.43  ? 55  LEU D CG  1 
ATOM 3973 C CD1 . LEU D 1 55  ? -30.346 43.136  133.834 1.00 94.43  ? 55  LEU D CD1 1 
ATOM 3974 C CD2 . LEU D 1 55  ? -29.723 44.362  135.917 1.00 94.43  ? 55  LEU D CD2 1 
ATOM 3975 N N   . ARG D 1 56  ? -28.133 39.404  137.290 1.00 96.70  ? 56  ARG D N   1 
ATOM 3976 C CA  . ARG D 1 56  ? -28.305 38.242  138.157 1.00 96.70  ? 56  ARG D CA  1 
ATOM 3977 C C   . ARG D 1 56  ? -27.520 38.376  139.461 1.00 96.70  ? 56  ARG D C   1 
ATOM 3978 O O   . ARG D 1 56  ? -28.076 38.219  140.561 1.00 96.70  ? 56  ARG D O   1 
ATOM 3979 C CB  . ARG D 1 56  ? -27.871 36.991  137.390 1.00 96.70  ? 56  ARG D CB  1 
ATOM 3980 C CG  . ARG D 1 56  ? -28.848 36.571  136.301 1.00 96.70  ? 56  ARG D CG  1 
ATOM 3981 C CD  . ARG D 1 56  ? -28.247 35.509  135.392 1.00 96.70  ? 56  ARG D CD  1 
ATOM 3982 N NE  . ARG D 1 56  ? -29.196 35.024  134.396 1.00 96.70  ? 56  ARG D NE  1 
ATOM 3983 C CZ  . ARG D 1 56  ? -28.870 34.622  133.174 1.00 96.70  ? 56  ARG D CZ  1 
ATOM 3984 N NH1 . ARG D 1 56  ? -27.615 34.630  132.754 1.00 96.70  ? 56  ARG D NH1 1 
ATOM 3985 N NH2 . ARG D 1 56  ? -29.820 34.169  132.364 1.00 96.70  ? 56  ARG D NH2 1 
ATOM 3986 N N   . GLN D 1 57  ? -26.226 38.693  139.356 1.00 97.73  ? 57  GLN D N   1 
ATOM 3987 C CA  . GLN D 1 57  ? -25.411 38.866  140.559 1.00 97.73  ? 57  GLN D CA  1 
ATOM 3988 C C   . GLN D 1 57  ? -25.953 39.977  141.454 1.00 97.73  ? 57  GLN D C   1 
ATOM 3989 O O   . GLN D 1 57  ? -26.080 39.803  142.676 1.00 97.73  ? 57  GLN D O   1 
ATOM 3990 C CB  . GLN D 1 57  ? -23.955 39.153  140.183 1.00 97.73  ? 57  GLN D CB  1 
ATOM 3991 C CG  . GLN D 1 57  ? -23.291 38.105  139.300 1.00 97.73  ? 57  GLN D CG  1 
ATOM 3992 C CD  . GLN D 1 57  ? -23.192 36.752  139.973 1.00 97.73  ? 57  GLN D CD  1 
ATOM 3993 O OE1 . GLN D 1 57  ? -22.927 36.663  141.169 1.00 97.73  ? 57  GLN D OE1 1 
ATOM 3994 N NE2 . GLN D 1 57  ? -23.385 35.688  139.202 1.00 97.73  ? 57  GLN D NE2 1 
ATOM 3995 N N   . ALA D 1 58  ? -26.301 41.128  140.901 1.00 95.97  ? 58  ALA D N   1 
ATOM 3996 C CA  . ALA D 1 58  ? -26.778 42.268  141.711 1.00 95.97  ? 58  ALA D CA  1 
ATOM 3997 C C   . ALA D 1 58  ? -28.033 41.870  142.494 1.00 95.97  ? 58  ALA D C   1 
ATOM 3998 O O   . ALA D 1 58  ? -28.075 42.107  143.742 1.00 95.97  ? 58  ALA D O   1 
ATOM 3999 C CB  . ALA D 1 58  ? -27.042 43.423  140.794 1.00 95.97  ? 58  ALA D CB  1 
ATOM 4000 N N   . ILE D 1 59  ? -29.014 41.272  141.820 1.00 96.68  ? 59  ILE D N   1 
ATOM 4001 C CA  . ILE D 1 59  ? -30.321 40.906  142.440 1.00 96.68  ? 59  ILE D CA  1 
ATOM 4002 C C   . ILE D 1 59  ? -30.092 39.985  143.640 1.00 96.68  ? 59  ILE D C   1 
ATOM 4003 O O   . ILE D 1 59  ? -30.619 40.299  144.721 1.00 96.68  ? 59  ILE D O   1 
ATOM 4004 C CB  . ILE D 1 59  ? -31.224 40.255  141.377 1.00 96.68  ? 59  ILE D CB  1 
ATOM 4005 C CG1 . ILE D 1 59  ? -31.626 41.256  140.292 1.00 96.68  ? 59  ILE D CG1 1 
ATOM 4006 C CG2 . ILE D 1 59  ? -32.441 39.610  142.017 1.00 96.68  ? 59  ILE D CG2 1 
ATOM 4007 C CD1 . ILE D 1 59  ? -32.212 40.615  139.059 1.00 96.68  ? 59  ILE D CD1 1 
ATOM 4008 N N   . LEU D 1 60  ? -29.317 38.917  143.479 1.00 98.11  ? 60  LEU D N   1 
ATOM 4009 C CA  . LEU D 1 60  ? -29.061 37.936  144.564 1.00 98.11  ? 60  LEU D CA  1 
ATOM 4010 C C   . LEU D 1 60  ? -28.453 38.657  145.767 1.00 98.11  ? 60  LEU D C   1 
ATOM 4011 O O   . LEU D 1 60  ? -28.907 38.396  146.914 1.00 98.11  ? 60  LEU D O   1 
ATOM 4012 C CB  . LEU D 1 60  ? -28.124 36.857  144.022 1.00 98.11  ? 60  LEU D CB  1 
ATOM 4013 C CG  . LEU D 1 60  ? -28.686 35.998  142.891 1.00 98.11  ? 60  LEU D CG  1 
ATOM 4014 C CD1 . LEU D 1 60  ? -27.661 34.980  142.423 1.00 98.11  ? 60  LEU D CD1 1 
ATOM 4015 C CD2 . LEU D 1 60  ? -29.967 35.301  143.316 1.00 98.11  ? 60  LEU D CD2 1 
ATOM 4016 N N   . CYS D 1 61  ? -27.493 39.550  145.537 1.00 100.94 ? 61  CYS D N   1 
ATOM 4017 C CA  . CYS D 1 61  ? -26.810 40.304  146.619 1.00 100.94 ? 61  CYS D CA  1 
ATOM 4018 C C   . CYS D 1 61  ? -27.817 41.186  147.360 1.00 100.94 ? 61  CYS D C   1 
ATOM 4019 O O   . CYS D 1 61  ? -27.827 41.160  148.614 1.00 100.94 ? 61  CYS D O   1 
ATOM 4020 C CB  . CYS D 1 61  ? -25.688 41.161  146.054 1.00 100.94 ? 61  CYS D CB  1 
ATOM 4021 S SG  . CYS D 1 61  ? -24.942 42.260  147.283 1.00 100.94 ? 61  CYS D SG  1 
ATOM 4022 N N   . TRP D 1 62  ? -28.654 41.919  146.626 1.00 99.35  ? 62  TRP D N   1 
ATOM 4023 C CA  . TRP D 1 62  ? -29.687 42.772  147.268 1.00 99.35  ? 62  TRP D CA  1 
ATOM 4024 C C   . TRP D 1 62  ? -30.594 41.878  148.112 1.00 99.35  ? 62  TRP D C   1 
ATOM 4025 O O   . TRP D 1 62  ? -30.927 42.273  149.244 1.00 99.35  ? 62  TRP D O   1 
ATOM 4026 C CB  . TRP D 1 62  ? -30.485 43.574  146.241 1.00 99.35  ? 62  TRP D CB  1 
ATOM 4027 C CG  . TRP D 1 62  ? -31.473 44.508  146.864 1.00 99.35  ? 62  TRP D CG  1 
ATOM 4028 C CD1 . TRP D 1 62  ? -32.832 44.405  146.845 1.00 99.35  ? 62  TRP D CD1 1 
ATOM 4029 C CD2 . TRP D 1 62  ? -31.170 45.686  147.628 1.00 99.35  ? 62  TRP D CD2 1 
ATOM 4030 N NE1 . TRP D 1 62  ? -33.396 45.443  147.537 1.00 99.35  ? 62  TRP D NE1 1 
ATOM 4031 C CE2 . TRP D 1 62  ? -32.401 46.245  148.029 1.00 99.35  ? 62  TRP D CE2 1 
ATOM 4032 C CE3 . TRP D 1 62  ? -29.984 46.323  148.008 1.00 99.35  ? 62  TRP D CE3 1 
ATOM 4033 C CZ2 . TRP D 1 62  ? -32.474 47.410  148.789 1.00 99.35  ? 62  TRP D CZ2 1 
ATOM 4034 C CZ3 . TRP D 1 62  ? -30.058 47.474  148.759 1.00 99.35  ? 62  TRP D CZ3 1 
ATOM 4035 C CH2 . TRP D 1 62  ? -31.287 48.007  149.144 1.00 99.35  ? 62  TRP D CH2 1 
ATOM 4036 N N   . GLY D 1 63  ? -30.968 40.713  147.591 1.00 103.18 ? 63  GLY D N   1 
ATOM 4037 C CA  . GLY D 1 63  ? -31.827 39.764  148.321 1.00 103.18 ? 63  GLY D CA  1 
ATOM 4038 C C   . GLY D 1 63  ? -31.194 39.357  149.636 1.00 103.18 ? 63  GLY D C   1 
ATOM 4039 O O   . GLY D 1 63  ? -31.889 39.421  150.678 1.00 103.18 ? 63  GLY D O   1 
ATOM 4040 N N   . GLU D 1 64  ? -29.915 38.982  149.612 1.00 105.11 ? 64  GLU D N   1 
ATOM 4041 C CA  . GLU D 1 64  ? -29.193 38.572  150.843 1.00 105.11 ? 64  GLU D CA  1 
ATOM 4042 C C   . GLU D 1 64  ? -29.164 39.747  151.819 1.00 105.11 ? 64  GLU D C   1 
ATOM 4043 O O   . GLU D 1 64  ? -29.378 39.512  153.017 1.00 105.11 ? 64  GLU D O   1 
ATOM 4044 C CB  . GLU D 1 64  ? -27.783 38.094  150.510 1.00 105.11 ? 64  GLU D CB  1 
ATOM 4045 C CG  . GLU D 1 64  ? -27.755 36.754  149.803 1.00 105.11 ? 64  GLU D CG  1 
ATOM 4046 C CD  . GLU D 1 64  ? -28.233 35.585  150.647 1.00 105.11 ? 64  GLU D CD  1 
ATOM 4047 O OE1 . GLU D 1 64  ? -28.403 35.769  151.867 1.00 105.11 ? 64  GLU D OE1 1 
ATOM 4048 O OE2 . GLU D 1 64  ? -28.437 34.494  150.082 1.00 105.11 ? 64  GLU D OE2 1 
ATOM 4049 N N   . LEU D 1 65  ? -28.926 40.965  151.334 1.00 106.05 ? 65  LEU D N   1 
ATOM 4050 C CA  . LEU D 1 65  ? -28.906 42.174  152.199 1.00 106.05 ? 65  LEU D CA  1 
ATOM 4051 C C   . LEU D 1 65  ? -30.263 42.329  152.883 1.00 106.05 ? 65  LEU D C   1 
ATOM 4052 O O   . LEU D 1 65  ? -30.273 42.574  154.091 1.00 106.05 ? 65  LEU D O   1 
ATOM 4053 C CB  . LEU D 1 65  ? -28.585 43.409  151.357 1.00 106.05 ? 65  LEU D CB  1 
ATOM 4054 C CG  . LEU D 1 65  ? -27.138 43.545  150.895 1.00 106.05 ? 65  LEU D CG  1 
ATOM 4055 C CD1 . LEU D 1 65  ? -27.000 44.690  149.908 1.00 106.05 ? 65  LEU D CD1 1 
ATOM 4056 C CD2 . LEU D 1 65  ? -26.208 43.750  152.078 1.00 106.05 ? 65  LEU D CD2 1 
ATOM 4057 N N   . MET D 1 66  ? -31.363 42.189  152.144 1.00 108.01 ? 66  MET D N   1 
ATOM 4058 C CA  . MET D 1 66  ? -32.733 42.314  152.706 1.00 108.01 ? 66  MET D CA  1 
ATOM 4059 C C   . MET D 1 66  ? -32.954 41.221  153.752 1.00 108.01 ? 66  MET D C   1 
ATOM 4060 O O   . MET D 1 66  ? -33.575 41.518  154.801 1.00 108.01 ? 66  MET D O   1 
ATOM 4061 C CB  . MET D 1 66  ? -33.782 42.184  151.603 1.00 108.01 ? 66  MET D CB  1 
ATOM 4062 C CG  . MET D 1 66  ? -33.774 43.334  150.617 1.00 108.01 ? 66  MET D CG  1 
ATOM 4063 S SD  . MET D 1 66  ? -33.795 44.954  151.422 1.00 108.01 ? 66  MET D SD  1 
ATOM 4064 C CE  . MET D 1 66  ? -32.043 45.325  151.459 1.00 108.01 ? 66  MET D CE  1 
ATOM 4065 N N   . THR D 1 67  ? -32.481 40.004  153.491 1.00 110.20 ? 67  THR D N   1 
ATOM 4066 C CA  . THR D 1 67  ? -32.585 38.881  154.458 1.00 110.20 ? 67  THR D CA  1 
ATOM 4067 C C   . THR D 1 67  ? -31.870 39.283  155.744 1.00 110.20 ? 67  THR D C   1 
ATOM 4068 O O   . THR D 1 67  ? -32.470 39.123  156.816 1.00 110.20 ? 67  THR D O   1 
ATOM 4069 C CB  . THR D 1 67  ? -31.995 37.590  153.886 1.00 110.20 ? 67  THR D CB  1 
ATOM 4070 O OG1 . THR D 1 67  ? -32.792 37.201  152.767 1.00 110.20 ? 67  THR D OG1 1 
ATOM 4071 C CG2 . THR D 1 67  ? -31.945 36.471  154.899 1.00 110.20 ? 67  THR D CG2 1 
ATOM 4072 N N   . LEU D 1 68  ? -30.652 39.817  155.637 1.00 113.76 ? 68  LEU D N   1 
ATOM 4073 C CA  . LEU D 1 68  ? -29.867 40.253  156.819 1.00 113.76 ? 68  LEU D CA  1 
ATOM 4074 C C   . LEU D 1 68  ? -30.655 41.325  157.551 1.00 113.76 ? 68  LEU D C   1 
ATOM 4075 O O   . LEU D 1 68  ? -30.679 41.280  158.773 1.00 113.76 ? 68  LEU D O   1 
ATOM 4076 C CB  . LEU D 1 68  ? -28.511 40.814  156.391 1.00 113.76 ? 68  LEU D CB  1 
ATOM 4077 C CG  . LEU D 1 68  ? -27.708 41.490  157.500 1.00 113.76 ? 68  LEU D CG  1 
ATOM 4078 C CD1 . LEU D 1 68  ? -26.216 41.403  157.224 1.00 113.76 ? 68  LEU D CD1 1 
ATOM 4079 C CD2 . LEU D 1 68  ? -28.133 42.937  157.684 1.00 113.76 ? 68  LEU D CD2 1 
ATOM 4080 N N   . ALA D 1 69  ? -31.248 42.262  156.823 1.00 115.06 ? 69  ALA D N   1 
ATOM 4081 C CA  . ALA D 1 69  ? -32.036 43.360  157.411 1.00 115.06 ? 69  ALA D CA  1 
ATOM 4082 C C   . ALA D 1 69  ? -33.158 42.765  158.252 1.00 115.06 ? 69  ALA D C   1 
ATOM 4083 O O   . ALA D 1 69  ? -33.279 43.177  159.401 1.00 115.06 ? 69  ALA D O   1 
ATOM 4084 C CB  . ALA D 1 69  ? -32.579 44.236  156.319 1.00 115.06 ? 69  ALA D CB  1 
ATOM 4085 N N   . THR D 1 70  ? -33.919 41.815  157.707 1.00 118.92 ? 70  THR D N   1 
ATOM 4086 C CA  . THR D 1 70  ? -35.054 41.171  158.421 1.00 118.92 ? 70  THR D CA  1 
ATOM 4087 C C   . THR D 1 70  ? -34.529 40.412  159.638 1.00 118.92 ? 70  THR D C   1 
ATOM 4088 O O   . THR D 1 70  ? -35.218 40.428  160.665 1.00 118.92 ? 70  THR D O   1 
ATOM 4089 C CB  . THR D 1 70  ? -35.826 40.234  157.489 1.00 118.92 ? 70  THR D CB  1 
ATOM 4090 O OG1 . THR D 1 70  ? -36.432 41.031  156.472 1.00 118.92 ? 70  THR D OG1 1 
ATOM 4091 C CG2 . THR D 1 70  ? -36.884 39.428  158.210 1.00 118.92 ? 70  THR D CG2 1 
ATOM 4092 N N   . TRP D 1 71  ? -33.373 39.759  159.522 1.00 122.35 ? 71  TRP D N   1 
ATOM 4093 C CA  . TRP D 1 71  ? -32.747 38.998  160.632 1.00 122.35 ? 71  TRP D CA  1 
ATOM 4094 C C   . TRP D 1 71  ? -32.407 39.964  161.757 1.00 122.35 ? 71  TRP D C   1 
ATOM 4095 O O   . TRP D 1 71  ? -32.629 39.602  162.919 1.00 122.35 ? 71  TRP D O   1 
ATOM 4096 C CB  . TRP D 1 71  ? -31.499 38.269  160.125 1.00 122.35 ? 71  TRP D CB  1 
ATOM 4097 C CG  . TRP D 1 71  ? -30.663 37.615  161.182 1.00 122.35 ? 71  TRP D CG  1 
ATOM 4098 C CD1 . TRP D 1 71  ? -30.626 36.288  161.493 1.00 122.35 ? 71  TRP D CD1 1 
ATOM 4099 C CD2 . TRP D 1 71  ? -29.707 38.253  162.045 1.00 122.35 ? 71  TRP D CD2 1 
ATOM 4100 N NE1 . TRP D 1 71  ? -29.727 36.059  162.499 1.00 122.35 ? 71  TRP D NE1 1 
ATOM 4101 C CE2 . TRP D 1 71  ? -29.146 37.246  162.856 1.00 122.35 ? 71  TRP D CE2 1 
ATOM 4102 C CE3 . TRP D 1 71  ? -29.279 39.572  162.218 1.00 122.35 ? 71  TRP D CE3 1 
ATOM 4103 C CZ2 . TRP D 1 71  ? -28.186 37.521  163.828 1.00 122.35 ? 71  TRP D CZ2 1 
ATOM 4104 C CZ3 . TRP D 1 71  ? -28.328 39.843  163.176 1.00 122.35 ? 71  TRP D CZ3 1 
ATOM 4105 C CH2 . TRP D 1 71  ? -27.790 38.830  163.967 1.00 122.35 ? 71  TRP D CH2 1 
ATOM 4106 N N   . VAL D 1 72  ? -31.872 41.134  161.418 1.00 124.87 ? 72  VAL D N   1 
ATOM 4107 C CA  . VAL D 1 72  ? -31.503 42.167  162.422 1.00 124.87 ? 72  VAL D CA  1 
ATOM 4108 C C   . VAL D 1 72  ? -32.825 42.642  162.989 1.00 124.87 ? 72  VAL D C   1 
ATOM 4109 O O   . VAL D 1 72  ? -32.894 42.913  164.211 1.00 124.87 ? 72  VAL D O   1 
ATOM 4110 C CB  . VAL D 1 72  ? -30.697 43.320  161.806 1.00 124.87 ? 72  VAL D CB  1 
ATOM 4111 C CG1 . VAL D 1 72  ? -30.674 44.548  162.701 1.00 124.87 ? 72  VAL D CG1 1 
ATOM 4112 C CG2 . VAL D 1 72  ? -29.286 42.887  161.448 1.00 124.87 ? 72  VAL D CG2 1 
ATOM 4113 N N   . GLY D 1 73  ? -33.850 42.702  162.133 1.00 127.64 ? 73  GLY D N   1 
ATOM 4114 C CA  . GLY D 1 73  ? -35.162 43.078  162.635 1.00 127.64 ? 73  GLY D CA  1 
ATOM 4115 C C   . GLY D 1 73  ? -35.690 42.215  163.765 1.00 127.64 ? 73  GLY D C   1 
ATOM 4116 O O   . GLY D 1 73  ? -36.238 42.728  164.743 1.00 127.64 ? 73  GLY D O   1 
ATOM 4117 N N   . VAL D 1 74  ? -35.528 40.899  163.656 1.00 130.74 ? 74  VAL D N   1 
ATOM 4118 C CA  . VAL D 1 74  ? -35.870 40.039  164.792 1.00 130.74 ? 74  VAL D CA  1 
ATOM 4119 C C   . VAL D 1 74  ? -34.880 40.159  165.953 1.00 130.74 ? 74  VAL D C   1 
ATOM 4120 O O   . VAL D 1 74  ? -35.283 40.354  167.105 1.00 130.74 ? 74  VAL D O   1 
ATOM 4121 C CB  . VAL D 1 74  ? -35.946 38.562  164.363 1.00 30.00  ? 74  VAL D CB  1 
ATOM 4122 C CG1 . VAL D 1 74  ? -36.200 37.670  165.569 1.00 30.00  ? 74  VAL D CG1 1 
ATOM 4123 C CG2 . VAL D 1 74  ? -37.027 38.367  163.312 1.00 30.00  ? 74  VAL D CG2 1 
ATOM 4124 N N   . ASN D 1 75  ? -33.583 40.047  165.674 1.00 130.35 ? 75  ASN D N   1 
ATOM 4125 C CA  . ASN D 1 75  ? -32.634 39.616  166.702 1.00 130.35 ? 75  ASN D CA  1 
ATOM 4126 C C   . ASN D 1 75  ? -32.323 40.691  167.743 1.00 130.35 ? 75  ASN D C   1 
ATOM 4127 O O   . ASN D 1 75  ? -32.387 40.425  168.949 1.00 130.35 ? 75  ASN D O   1 
ATOM 4128 C CB  . ASN D 1 75  ? -31.364 39.104  166.034 1.00 130.35 ? 75  ASN D CB  1 
ATOM 4129 C CG  . ASN D 1 75  ? -31.541 37.702  165.495 1.00 130.35 ? 75  ASN D CG  1 
ATOM 4130 O OD1 . ASN D 1 75  ? -31.356 37.455  164.311 1.00 130.35 ? 75  ASN D OD1 1 
ATOM 4131 N ND2 . ASN D 1 75  ? -31.890 36.771  166.374 1.00 130.35 ? 75  ASN D ND2 1 
ATOM 4132 N N   . LEU D 1 76  ? -31.981 41.903  167.315 1.00 133.74 ? 76  LEU D N   1 
ATOM 4133 C CA  . LEU D 1 76  ? -31.554 42.930  168.262 1.00 133.74 ? 76  LEU D CA  1 
ATOM 4134 C C   . LEU D 1 76  ? -32.724 43.538  169.027 1.00 133.74 ? 76  LEU D C   1 
ATOM 4135 O O   . LEU D 1 76  ? -33.731 43.950  168.442 1.00 133.74 ? 76  LEU D O   1 
ATOM 4136 C CB  . LEU D 1 76  ? -30.775 44.029  167.539 1.00 133.74 ? 76  LEU D CB  1 
ATOM 4137 C CG  . LEU D 1 76  ? -29.398 43.658  166.971 1.00 133.74 ? 76  LEU D CG  1 
ATOM 4138 C CD1 . LEU D 1 76  ? -29.470 42.658  165.824 1.00 133.74 ? 76  LEU D CD1 1 
ATOM 4139 C CD2 . LEU D 1 76  ? -28.664 44.916  166.535 1.00 133.74 ? 76  LEU D CD2 1 
ATOM 4140 N N   . GLU D 1 77  ? -32.565 43.585  170.354 1.00 142.20 ? 77  GLU D N   1 
ATOM 4141 C CA  . GLU D 1 77  ? -33.568 44.160  171.246 1.00 142.20 ? 77  GLU D CA  1 
ATOM 4142 C C   . GLU D 1 77  ? -33.606 45.685  171.166 1.00 142.20 ? 77  GLU D C   1 
ATOM 4143 O O   . GLU D 1 77  ? -34.678 46.277  170.998 1.00 142.20 ? 77  GLU D O   1 
ATOM 4144 C CB  . GLU D 1 77  ? -33.327 43.674  172.684 1.00 142.20 ? 77  GLU D CB  1 
ATOM 4145 C CG  . GLU D 1 77  ? -33.549 42.186  172.961 1.00 142.20 ? 77  GLU D CG  1 
ATOM 4146 C CD  . GLU D 1 77  ? -33.215 41.804  174.388 1.00 142.20 ? 77  GLU D CD  1 
ATOM 4147 O OE1 . GLU D 1 77  ? -32.634 42.643  175.108 1.00 142.20 ? 77  GLU D OE1 1 
ATOM 4148 O OE2 . GLU D 1 77  ? -33.532 40.665  174.790 1.00 142.20 ? 77  GLU D OE2 1 
ATOM 4149 N N   . ASP D 1 78  ? -32.458 46.342  171.286 1.00 142.30 ? 78  ASP D N   1 
ATOM 4150 C CA  . ASP D 1 78  ? -32.437 47.804  171.299 1.00 142.30 ? 78  ASP D CA  1 
ATOM 4151 C C   . ASP D 1 78  ? -32.905 48.361  169.961 1.00 142.30 ? 78  ASP D C   1 
ATOM 4152 O O   . ASP D 1 78  ? -32.293 48.067  168.926 1.00 142.30 ? 78  ASP D O   1 
ATOM 4153 C CB  . ASP D 1 78  ? -31.031 48.304  171.611 1.00 142.30 ? 78  ASP D CB  1 
ATOM 4154 C CG  . ASP D 1 78  ? -30.961 49.815  171.710 1.00 142.30 ? 78  ASP D CG  1 
ATOM 4155 O OD1 . ASP D 1 78  ? -31.427 50.367  172.729 1.00 142.30 ? 78  ASP D OD1 1 
ATOM 4156 O OD2 . ASP D 1 78  ? -30.445 50.451  170.768 1.00 142.30 ? 78  ASP D OD2 1 
ATOM 4157 N N   . PRO D 1 79  ? -33.974 49.166  169.932 1.00 140.67 ? 79  PRO D N   1 
ATOM 4158 C CA  . PRO D 1 79  ? -34.438 49.720  168.648 1.00 140.67 ? 79  PRO D CA  1 
ATOM 4159 C C   . PRO D 1 79  ? -33.453 50.644  167.959 1.00 140.67 ? 79  PRO D C   1 
ATOM 4160 O O   . PRO D 1 79  ? -33.387 50.645  166.726 1.00 140.67 ? 79  PRO D O   1 
ATOM 4161 C CB  . PRO D 1 79  ? -35.726 50.462  169.043 1.00 140.67 ? 79  PRO D CB  1 
ATOM 4162 C CG  . PRO D 1 79  ? -35.514 50.826  170.469 1.00 140.67 ? 79  PRO D CG  1 
ATOM 4163 C CD  . PRO D 1 79  ? -34.814 49.631  171.047 1.00 140.67 ? 79  PRO D CD  1 
ATOM 4164 N N   . ALA D 1 80  ? -32.703 51.449  168.709 1.00 138.00 ? 80  ALA D N   1 
ATOM 4165 C CA  . ALA D 1 80  ? -31.902 52.499  168.086 1.00 138.00 ? 80  ALA D CA  1 
ATOM 4166 C C   . ALA D 1 80  ? -30.806 51.931  167.191 1.00 138.00 ? 80  ALA D C   1 
ATOM 4167 O O   . ALA D 1 80  ? -30.602 52.406  166.067 1.00 138.00 ? 80  ALA D O   1 
ATOM 4168 C CB  . ALA D 1 80  ? -31.296 53.398  169.163 1.00 138.00 ? 80  ALA D CB  1 
ATOM 4169 N N   . SER D 1 81  ? -30.097 50.908  167.669 1.00 138.34 ? 81  SER D N   1 
ATOM 4170 C CA  . SER D 1 81  ? -29.040 50.291  166.872 1.00 138.34 ? 81  SER D CA  1 
ATOM 4171 C C   . SER D 1 81  ? -29.568 49.637  165.597 1.00 138.34 ? 81  SER D C   1 
ATOM 4172 O O   . SER D 1 81  ? -29.010 49.836  164.508 1.00 138.34 ? 81  SER D O   1 
ATOM 4173 C CB  . SER D 1 81  ? -28.299 49.262  167.725 1.00 138.34 ? 81  SER D CB  1 
ATOM 4174 O OG  . SER D 1 81  ? -29.203 48.357  168.336 1.00 138.34 ? 81  SER D OG  1 
ATOM 4175 N N   . ARG D 1 82  ? -30.650 48.864  165.699 1.00 136.88 ? 82  ARG D N   1 
ATOM 4176 C CA  . ARG D 1 82  ? -31.222 48.275  164.491 1.00 136.88 ? 82  ARG D CA  1 
ATOM 4177 C C   . ARG D 1 82  ? -31.763 49.338  163.539 1.00 136.88 ? 82  ARG D C   1 
ATOM 4178 O O   . ARG D 1 82  ? -31.641 49.197  162.319 1.00 136.88 ? 82  ARG D O   1 
ATOM 4179 C CB  . ARG D 1 82  ? -32.301 47.247  164.846 1.00 136.88 ? 82  ARG D CB  1 
ATOM 4180 C CG  . ARG D 1 82  ? -33.437 47.705  165.749 1.00 136.88 ? 82  ARG D CG  1 
ATOM 4181 C CD  . ARG D 1 82  ? -34.320 46.497  166.084 1.00 136.88 ? 82  ARG D CD  1 
ATOM 4182 N NE  . ARG D 1 82  ? -34.939 46.561  167.405 1.00 136.88 ? 82  ARG D NE  1 
ATOM 4183 C CZ  . ARG D 1 82  ? -36.164 47.011  167.648 1.00 136.88 ? 82  ARG D CZ  1 
ATOM 4184 N NH1 . ARG D 1 82  ? -36.934 47.488  166.683 1.00 136.88 ? 82  ARG D NH1 1 
ATOM 4185 N NH2 . ARG D 1 82  ? -36.630 46.978  168.894 1.00 136.88 ? 82  ARG D NH2 1 
ATOM 4186 N N   . ASP D 1 83  ? -32.398 50.383  164.066 1.00 133.99 ? 83  ASP D N   1 
ATOM 4187 C CA  . ASP D 1 83  ? -32.857 51.470  163.205 1.00 133.99 ? 83  ASP D CA  1 
ATOM 4188 C C   . ASP D 1 83  ? -31.700 52.123  162.455 1.00 133.99 ? 83  ASP D C   1 
ATOM 4189 O O   . ASP D 1 83  ? -31.801 52.393  161.252 1.00 133.99 ? 83  ASP D O   1 
ATOM 4190 C CB  . ASP D 1 83  ? -33.603 52.510  164.039 1.00 133.99 ? 83  ASP D CB  1 
ATOM 4191 C CG  . ASP D 1 83  ? -34.906 51.979  164.601 1.00 133.99 ? 83  ASP D CG  1 
ATOM 4192 O OD1 . ASP D 1 83  ? -35.420 50.974  164.067 1.00 133.99 ? 83  ASP D OD1 1 
ATOM 4193 O OD2 . ASP D 1 83  ? -35.415 52.564  165.580 1.00 133.99 ? 83  ASP D OD2 1 
ATOM 4194 N N   . LEU D 1 84  ? -30.594 52.387  163.154 1.00 127.22 ? 84  LEU D N   1 
ATOM 4195 C CA  . LEU D 1 84  ? -29.392 52.911  162.508 1.00 127.22 ? 84  LEU D CA  1 
ATOM 4196 C C   . LEU D 1 84  ? -28.897 51.992  161.398 1.00 127.22 ? 84  LEU D C   1 
ATOM 4197 O O   . LEU D 1 84  ? -28.621 52.441  160.276 1.00 127.22 ? 84  LEU D O   1 
ATOM 4198 C CB  . LEU D 1 84  ? -28.292 53.111  163.551 1.00 127.22 ? 84  LEU D CB  1 
ATOM 4199 C CG  . LEU D 1 84  ? -28.488 54.240  164.563 1.00 127.22 ? 84  LEU D CG  1 
ATOM 4200 C CD1 . LEU D 1 84  ? -27.528 54.073  165.727 1.00 127.22 ? 84  LEU D CD1 1 
ATOM 4201 C CD2 . LEU D 1 84  ? -28.296 55.591  163.900 1.00 127.22 ? 84  LEU D CD2 1 
ATOM 4202 N N   . VAL D 1 85  ? -28.814 50.693  161.684 1.00 124.54 ? 85  VAL D N   1 
ATOM 4203 C CA  . VAL D 1 85  ? -28.374 49.729  160.676 1.00 124.54 ? 85  VAL D CA  1 
ATOM 4204 C C   . VAL D 1 85  ? -29.301 49.735  159.465 1.00 124.54 ? 85  VAL D C   1 
ATOM 4205 O O   . VAL D 1 85  ? -28.845 49.738  158.315 1.00 124.54 ? 85  VAL D O   1 
ATOM 4206 C CB  . VAL D 1 85  ? -28.275 48.322  161.295 1.00 124.54 ? 85  VAL D CB  1 
ATOM 4207 C CG1 . VAL D 1 85  ? -28.036 47.280  160.216 1.00 124.54 ? 85  VAL D CG1 1 
ATOM 4208 C CG2 . VAL D 1 85  ? -27.165 48.277  162.331 1.00 124.54 ? 85  VAL D CG2 1 
ATOM 4209 N N   . VAL D 1 86  ? -30.610 49.724  159.700 1.00 122.67 ? 86  VAL D N   1 
ATOM 4210 C CA  . VAL D 1 86  ? -31.557 49.650  158.592 1.00 122.67 ? 86  VAL D CA  1 
ATOM 4211 C C   . VAL D 1 86  ? -31.490 50.910  157.733 1.00 122.67 ? 86  VAL D C   1 
ATOM 4212 O O   . VAL D 1 86  ? -31.464 50.834  156.497 1.00 122.67 ? 86  VAL D O   1 
ATOM 4213 C CB  . VAL D 1 86  ? -32.977 49.402  159.133 1.00 122.67 ? 86  VAL D CB  1 
ATOM 4214 C CG1 . VAL D 1 86  ? -34.027 49.645  158.057 1.00 122.67 ? 86  VAL D CG1 1 
ATOM 4215 C CG2 . VAL D 1 86  ? -33.091 47.988  159.685 1.00 122.67 ? 86  VAL D CG2 1 
ATOM 4216 N N   . SER D 1 87  ? -31.469 52.086  158.368 1.00 123.78 ? 87  SER D N   1 
ATOM 4217 C CA  . SER D 1 87  ? -31.366 53.323  157.599 1.00 123.78 ? 87  SER D CA  1 
ATOM 4218 C C   . SER D 1 87  ? -30.077 53.374  156.789 1.00 123.78 ? 87  SER D C   1 
ATOM 4219 O O   . SER D 1 87  ? -30.091 53.747  155.607 1.00 123.78 ? 87  SER D O   1 
ATOM 4220 C CB  . SER D 1 87  ? -31.446 54.538  158.526 1.00 30.00  ? 87  SER D CB  1 
ATOM 4221 O OG  . SER D 1 87  ? -32.717 54.622  159.147 1.00 30.00  ? 87  SER D OG  1 
ATOM 4222 N N   . TYR D 1 88  ? -28.966 52.935  157.383 1.00 114.41 ? 88  TYR D N   1 
ATOM 4223 C CA  . TYR D 1 88  ? -27.701 52.919  156.658 1.00 114.41 ? 88  TYR D CA  1 
ATOM 4224 C C   . TYR D 1 88  ? -27.774 52.002  155.449 1.00 114.41 ? 88  TYR D C   1 
ATOM 4225 O O   . TYR D 1 88  ? -27.411 52.391  154.332 1.00 114.41 ? 88  TYR D O   1 
ATOM 4226 C CB  . TYR D 1 88  ? -26.573 52.477  157.591 1.00 114.41 ? 88  TYR D CB  1 
ATOM 4227 C CG  . TYR D 1 88  ? -25.221 52.435  156.923 1.00 114.41 ? 88  TYR D CG  1 
ATOM 4228 C CD1 . TYR D 1 88  ? -24.780 51.284  156.287 1.00 114.41 ? 88  TYR D CD1 1 
ATOM 4229 C CD2 . TYR D 1 88  ? -24.383 53.540  156.931 1.00 114.41 ? 88  TYR D CD2 1 
ATOM 4230 C CE1 . TYR D 1 88  ? -23.545 51.231  155.679 1.00 114.41 ? 88  TYR D CE1 1 
ATOM 4231 C CE2 . TYR D 1 88  ? -23.148 53.501  156.316 1.00 114.41 ? 88  TYR D CE2 1 
ATOM 4232 C CZ  . TYR D 1 88  ? -22.736 52.344  155.690 1.00 114.41 ? 88  TYR D CZ  1 
ATOM 4233 O OH  . TYR D 1 88  ? -21.509 52.300  155.071 1.00 114.41 ? 88  TYR D OH  1 
ATOM 4234 N N   . VAL D 1 89  ? -28.228 50.769  155.657 1.00 113.77 ? 89  VAL D N   1 
ATOM 4235 C CA  . VAL D 1 89  ? -28.272 49.804  154.567 1.00 113.77 ? 89  VAL D CA  1 
ATOM 4236 C C   . VAL D 1 89  ? -29.149 50.312  153.432 1.00 113.77 ? 89  VAL D C   1 
ATOM 4237 O O   . VAL D 1 89  ? -28.693 50.442  152.284 1.00 113.77 ? 89  VAL D O   1 
ATOM 4238 C CB  . VAL D 1 89  ? -28.765 48.439  155.084 1.00 113.77 ? 89  VAL D CB  1 
ATOM 4239 C CG1 . VAL D 1 89  ? -29.107 47.511  153.924 1.00 113.77 ? 89  VAL D CG1 1 
ATOM 4240 C CG2 . VAL D 1 89  ? -27.721 47.805  155.983 1.00 113.77 ? 89  VAL D CG2 1 
ATOM 4241 N N   . ASN D 1 90  ? -30.370 50.745  153.763 1.00 114.12 ? 90  ASN D N   1 
ATOM 4242 C CA  . ASN D 1 90  ? -31.283 51.216  152.729 1.00 114.12 ? 90  ASN D CA  1 
ATOM 4243 C C   . ASN D 1 90  ? -30.720 52.398  151.962 1.00 114.12 ? 90  ASN D C   1 
ATOM 4244 O O   . ASN D 1 90  ? -30.587 52.320  150.739 1.00 114.12 ? 90  ASN D O   1 
ATOM 4245 C CB  . ASN D 1 90  ? -32.628 51.591  153.352 1.00 114.12 ? 90  ASN D CB  1 
ATOM 4246 C CG  . ASN D 1 90  ? -33.421 50.383  153.803 1.00 114.12 ? 90  ASN D CG  1 
ATOM 4247 O OD1 . ASN D 1 90  ? -33.198 49.268  153.334 1.00 114.12 ? 90  ASN D OD1 1 
ATOM 4248 N ND2 . ASN D 1 90  ? -34.366 50.602  154.709 1.00 114.12 ? 90  ASN D ND2 1 
ATOM 4249 N N   . THR D 1 91  ? -30.144 53.378  152.650 1.00 110.86 ? 91  THR D N   1 
ATOM 4250 C CA  . THR D 1 91  ? -29.703 54.565  151.926 1.00 110.86 ? 91  THR D CA  1 
ATOM 4251 C C   . THR D 1 91  ? -28.471 54.262  151.086 1.00 110.86 ? 91  THR D C   1 
ATOM 4252 O O   . THR D 1 91  ? -28.489 54.421  149.851 1.00 110.86 ? 91  THR D O   1 
ATOM 4253 C CB  . THR D 1 91  ? -29.420 55.700  152.910 1.00 110.86 ? 91  THR D CB  1 
ATOM 4254 O OG1 . THR D 1 91  ? -30.538 55.865  153.789 1.00 110.86 ? 91  THR D OG1 1 
ATOM 4255 C CG2 . THR D 1 91  ? -29.168 57.005  152.168 1.00 110.86 ? 91  THR D CG2 1 
ATOM 4256 N N   . ASN D 1 92  ? -27.433 53.718  151.711 1.00 107.30 ? 92  ASN D N   1 
ATOM 4257 C CA  . ASN D 1 92  ? -26.146 53.626  151.043 1.00 107.30 ? 92  ASN D CA  1 
ATOM 4258 C C   . ASN D 1 92  ? -26.139 52.537  149.977 1.00 107.30 ? 92  ASN D C   1 
ATOM 4259 O O   . ASN D 1 92  ? -25.744 52.801  148.836 1.00 107.30 ? 92  ASN D O   1 
ATOM 4260 C CB  . ASN D 1 92  ? -25.050 53.378  152.079 1.00 107.30 ? 92  ASN D CB  1 
ATOM 4261 C CG  . ASN D 1 92  ? -24.900 54.533  153.048 1.00 107.30 ? 92  ASN D CG  1 
ATOM 4262 O OD1 . ASN D 1 92  ? -24.845 54.335  154.262 1.00 107.30 ? 92  ASN D OD1 1 
ATOM 4263 N ND2 . ASN D 1 92  ? -24.860 55.749  152.521 1.00 107.30 ? 92  ASN D ND2 1 
ATOM 4264 N N   . MET D 1 93  ? -26.568 51.311  150.294 1.00 105.82 ? 93  MET D N   1 
ATOM 4265 C CA  . MET D 1 93  ? -26.638 50.327  149.218 1.00 105.82 ? 93  MET D CA  1 
ATOM 4266 C C   . MET D 1 93  ? -27.741 50.639  148.207 1.00 105.82 ? 93  MET D C   1 
ATOM 4267 O O   . MET D 1 93  ? -27.580 50.343  147.016 1.00 105.82 ? 93  MET D O   1 
ATOM 4268 C CB  . MET D 1 93  ? -26.769 48.908  149.774 1.00 105.82 ? 93  MET D CB  1 
ATOM 4269 C CG  . MET D 1 93  ? -25.434 48.360  150.295 1.00 105.82 ? 93  MET D CG  1 
ATOM 4270 S SD  . MET D 1 93  ? -24.766 48.993  151.840 1.00 105.82 ? 93  MET D SD  1 
ATOM 4271 C CE  . MET D 1 93  ? -25.851 48.191  153.002 1.00 105.82 ? 93  MET D CE  1 
ATOM 4272 N N   . GLY D 1 94  ? -28.892 51.164  148.643 1.00 102.60 ? 94  GLY D N   1 
ATOM 4273 C CA  . GLY D 1 94  ? -29.936 51.507  147.696 1.00 102.60 ? 94  GLY D CA  1 
ATOM 4274 C C   . GLY D 1 94  ? -29.487 52.435  146.586 1.00 102.60 ? 94  GLY D C   1 
ATOM 4275 O O   . GLY D 1 94  ? -29.793 52.207  145.417 1.00 102.60 ? 94  GLY D O   1 
ATOM 4276 N N   . LEU D 1 95  ? -28.776 53.513  146.930 1.00 98.66  ? 95  LEU D N   1 
ATOM 4277 C CA  . LEU D 1 95  ? -28.296 54.413  145.877 1.00 98.66  ? 95  LEU D CA  1 
ATOM 4278 C C   . LEU D 1 95  ? -27.376 53.729  144.856 1.00 98.66  ? 95  LEU D C   1 
ATOM 4279 O O   . LEU D 1 95  ? -27.558 53.891  143.637 1.00 98.66  ? 95  LEU D O   1 
ATOM 4280 C CB  . LEU D 1 95  ? -27.574 55.598  146.518 1.00 98.66  ? 95  LEU D CB  1 
ATOM 4281 C CG  . LEU D 1 95  ? -27.046 56.681  145.577 1.00 98.66  ? 95  LEU D CG  1 
ATOM 4282 C CD1 . LEU D 1 95  ? -28.159 57.253  144.717 1.00 98.66  ? 95  LEU D CD1 1 
ATOM 4283 C CD2 . LEU D 1 95  ? -26.368 57.781  146.374 1.00 98.66  ? 95  LEU D CD2 1 
ATOM 4284 N N   . LYS D 1 96  ? -26.425 52.919  145.322 1.00 96.68  ? 96  LYS D N   1 
ATOM 4285 C CA  . LYS D 1 96  ? -25.543 52.191  144.407 1.00 96.68  ? 96  LYS D CA  1 
ATOM 4286 C C   . LYS D 1 96  ? -26.297 51.202  143.521 1.00 96.68  ? 96  LYS D C   1 
ATOM 4287 O O   . LYS D 1 96  ? -26.072 51.143  142.300 1.00 96.68  ? 96  LYS D O   1 
ATOM 4288 C CB  . LYS D 1 96  ? -24.458 51.474  145.210 1.00 96.68  ? 96  LYS D CB  1 
ATOM 4289 C CG  . LYS D 1 96  ? -23.474 52.421  145.878 1.00 96.68  ? 96  LYS D CG  1 
ATOM 4290 C CD  . LYS D 1 96  ? -22.390 51.666  146.627 1.00 96.68  ? 96  LYS D CD  1 
ATOM 4291 C CE  . LYS D 1 96  ? -21.497 52.608  147.418 1.00 96.68  ? 96  LYS D CE  1 
ATOM 4292 N NZ  . LYS D 1 96  ? -20.624 53.445  146.549 1.00 96.68  ? 96  LYS D NZ  1 
ATOM 4293 N N   . PHE D 1 97  ? -27.201 50.441  144.130 1.00 94.80  ? 97  PHE D N   1 
ATOM 4294 C CA  . PHE D 1 97  ? -27.993 49.451  143.364 1.00 94.80  ? 97  PHE D CA  1 
ATOM 4295 C C   . PHE D 1 97  ? -28.811 50.211  142.322 1.00 94.80  ? 97  PHE D C   1 
ATOM 4296 O O   . PHE D 1 97  ? -28.835 49.786  141.157 1.00 94.80  ? 97  PHE D O   1 
ATOM 4297 C CB  . PHE D 1 97  ? -28.846 48.637  144.338 1.00 30.00  ? 97  PHE D CB  1 
ATOM 4298 C CG  . PHE D 1 97  ? -29.488 47.396  143.779 1.00 30.00  ? 97  PHE D CG  1 
ATOM 4299 C CD1 . PHE D 1 97  ? -28.765 46.511  142.997 1.00 30.00  ? 97  PHE D CD1 1 
ATOM 4300 C CD2 . PHE D 1 97  ? -30.809 47.095  144.063 1.00 30.00  ? 97  PHE D CD2 1 
ATOM 4301 C CE1 . PHE D 1 97  ? -29.357 45.366  142.492 1.00 30.00  ? 97  PHE D CE1 1 
ATOM 4302 C CE2 . PHE D 1 97  ? -31.399 45.948  143.561 1.00 30.00  ? 97  PHE D CE2 1 
ATOM 4303 C CZ  . PHE D 1 97  ? -30.672 45.086  142.775 1.00 30.00  ? 97  PHE D CZ  1 
ATOM 4304 N N   . ARG D 1 98  ? -29.437 51.313  142.729 1.00 94.45  ? 98  ARG D N   1 
ATOM 4305 C CA  . ARG D 1 98  ? -30.255 52.115  141.830 1.00 94.45  ? 98  ARG D CA  1 
ATOM 4306 C C   . ARG D 1 98  ? -29.468 52.539  140.596 1.00 94.45  ? 98  ARG D C   1 
ATOM 4307 O O   . ARG D 1 98  ? -29.933 52.380  139.461 1.00 94.45  ? 98  ARG D O   1 
ATOM 4308 C CB  . ARG D 1 98  ? -30.809 53.327  142.579 1.00 94.45  ? 98  ARG D CB  1 
ATOM 4309 C CG  . ARG D 1 98  ? -31.940 52.964  143.529 1.00 94.45  ? 98  ARG D CG  1 
ATOM 4310 C CD  . ARG D 1 98  ? -32.192 54.035  144.577 1.00 94.45  ? 98  ARG D CD  1 
ATOM 4311 N NE  . ARG D 1 98  ? -32.585 55.313  143.994 1.00 94.45  ? 98  ARG D NE  1 
ATOM 4312 C CZ  . ARG D 1 98  ? -32.382 56.491  144.568 1.00 94.45  ? 98  ARG D CZ  1 
ATOM 4313 N NH1 . ARG D 1 98  ? -31.879 56.591  145.786 1.00 94.45  ? 98  ARG D NH1 1 
ATOM 4314 N NH2 . ARG D 1 98  ? -32.714 57.598  143.910 1.00 94.45  ? 98  ARG D NH2 1 
ATOM 4315 N N   . GLN D 1 99  ? -28.247 53.042  140.801 1.00 92.76  ? 99  GLN D N   1 
ATOM 4316 C CA  . GLN D 1 99  ? -27.399 53.409  139.665 1.00 92.76  ? 99  GLN D CA  1 
ATOM 4317 C C   . GLN D 1 99  ? -27.100 52.221  138.754 1.00 92.76  ? 99  GLN D C   1 
ATOM 4318 O O   . GLN D 1 99  ? -27.270 52.305  137.527 1.00 92.76  ? 99  GLN D O   1 
ATOM 4319 C CB  . GLN D 1 99  ? -26.086 54.007  140.166 1.00 92.76  ? 99  GLN D CB  1 
ATOM 4320 C CG  . GLN D 1 99  ? -26.234 55.280  140.957 1.00 92.76  ? 99  GLN D CG  1 
ATOM 4321 C CD  . GLN D 1 99  ? -24.918 56.015  141.117 1.00 92.76  ? 99  GLN D CD  1 
ATOM 4322 O OE1 . GLN D 1 99  ? -23.907 55.639  140.524 1.00 92.76  ? 99  GLN D OE1 1 
ATOM 4323 N NE2 . GLN D 1 99  ? -24.926 57.076  141.913 1.00 92.76  ? 99  GLN D NE2 1 
ATOM 4324 N N   . LEU D 1 100 ? -26.673 51.097  139.330 1.00 92.75  ? 100 LEU D N   1 
ATOM 4325 C CA  . LEU D 1 100 ? -26.290 49.969  138.483 1.00 92.75  ? 100 LEU D CA  1 
ATOM 4326 C C   . LEU D 1 100 ? -27.487 49.391  137.729 1.00 92.75  ? 100 LEU D C   1 
ATOM 4327 O O   . LEU D 1 100 ? -27.377 49.057  136.537 1.00 92.75  ? 100 LEU D O   1 
ATOM 4328 C CB  . LEU D 1 100 ? -25.602 48.896  139.327 1.00 92.75  ? 100 LEU D CB  1 
ATOM 4329 C CG  . LEU D 1 100 ? -25.005 47.715  138.559 1.00 92.75  ? 100 LEU D CG  1 
ATOM 4330 C CD1 . LEU D 1 100 ? -23.761 47.186  139.255 1.00 92.75  ? 100 LEU D CD1 1 
ATOM 4331 C CD2 . LEU D 1 100 ? -26.019 46.602  138.419 1.00 92.75  ? 100 LEU D CD2 1 
ATOM 4332 N N   . LEU D 1 101 ? -28.639 49.277  138.393 1.00 93.28  ? 101 LEU D N   1 
ATOM 4333 C CA  . LEU D 1 101 ? -29.840 48.805  137.715 1.00 93.28  ? 101 LEU D CA  1 
ATOM 4334 C C   . LEU D 1 101 ? -30.240 49.747  136.588 1.00 93.28  ? 101 LEU D C   1 
ATOM 4335 O O   . LEU D 1 101 ? -30.556 49.300  135.479 1.00 93.28  ? 101 LEU D O   1 
ATOM 4336 C CB  . LEU D 1 101 ? -30.983 48.658  138.721 1.00 93.28  ? 101 LEU D CB  1 
ATOM 4337 C CG  . LEU D 1 101 ? -30.968 47.420  139.619 1.00 93.28  ? 101 LEU D CG  1 
ATOM 4338 C CD1 . LEU D 1 101 ? -32.097 47.491  140.629 1.00 93.28  ? 101 LEU D CD1 1 
ATOM 4339 C CD2 . LEU D 1 101 ? -31.069 46.140  138.803 1.00 93.28  ? 101 LEU D CD2 1 
ATOM 4340 N N   . TRP D 1 102 ? -30.258 51.057  136.854 1.00 89.69  ? 102 TRP D N   1 
ATOM 4341 C CA  . TRP D 1 102 ? -30.625 51.992  135.799 1.00 89.69  ? 102 TRP D CA  1 
ATOM 4342 C C   . TRP D 1 102 ? -29.720 51.821  134.591 1.00 89.69  ? 102 TRP D C   1 
ATOM 4343 O O   . TRP D 1 102 ? -30.196 51.749  133.451 1.00 89.69  ? 102 TRP D O   1 
ATOM 4344 C CB  . TRP D 1 102 ? -30.547 53.431  136.302 1.00 89.69  ? 102 TRP D CB  1 
ATOM 4345 C CG  . TRP D 1 102 ? -30.847 54.433  135.224 1.00 89.69  ? 102 TRP D CG  1 
ATOM 4346 C CD1 . TRP D 1 102 ? -32.078 54.869  134.832 1.00 89.69  ? 102 TRP D CD1 1 
ATOM 4347 C CD2 . TRP D 1 102 ? -29.900 55.098  134.379 1.00 89.69  ? 102 TRP D CD2 1 
ATOM 4348 N NE1 . TRP D 1 102 ? -31.955 55.778  133.811 1.00 89.69  ? 102 TRP D NE1 1 
ATOM 4349 C CE2 . TRP D 1 102 ? -30.629 55.924  133.503 1.00 89.69  ? 102 TRP D CE2 1 
ATOM 4350 C CE3 . TRP D 1 102 ? -28.507 55.062  134.267 1.00 89.69  ? 102 TRP D CE3 1 
ATOM 4351 C CZ2 . TRP D 1 102 ? -30.012 56.720  132.541 1.00 89.69  ? 102 TRP D CZ2 1 
ATOM 4352 C CZ3 . TRP D 1 102 ? -27.897 55.868  133.325 1.00 89.69  ? 102 TRP D CZ3 1 
ATOM 4353 C CH2 . TRP D 1 102 ? -28.648 56.685  132.475 1.00 89.69  ? 102 TRP D CH2 1 
ATOM 4354 N N   . PHE D 1 103 ? -28.417 51.659  134.829 1.00 89.73  ? 103 PHE D N   1 
ATOM 4355 C CA  . PHE D 1 103 ? -27.476 51.568  133.719 1.00 89.73  ? 103 PHE D CA  1 
ATOM 4356 C C   . PHE D 1 103 ? -27.691 50.305  132.895 1.00 89.73  ? 103 PHE D C   1 
ATOM 4357 O O   . PHE D 1 103 ? -27.819 50.374  131.667 1.00 89.73  ? 103 PHE D O   1 
ATOM 4358 C CB  . PHE D 1 103 ? -26.040 51.616  134.239 1.00 89.73  ? 103 PHE D CB  1 
ATOM 4359 C CG  . PHE D 1 103 ? -25.005 51.599  133.149 1.00 89.73  ? 103 PHE D CG  1 
ATOM 4360 C CD1 . PHE D 1 103 ? -24.636 52.765  132.506 1.00 89.73  ? 103 PHE D CD1 1 
ATOM 4361 C CD2 . PHE D 1 103 ? -24.407 50.411  132.765 1.00 89.73  ? 103 PHE D CD2 1 
ATOM 4362 C CE1 . PHE D 1 103 ? -23.692 52.747  131.499 1.00 89.73  ? 103 PHE D CE1 1 
ATOM 4363 C CE2 . PHE D 1 103 ? -23.449 50.391  131.771 1.00 89.73  ? 103 PHE D CE2 1 
ATOM 4364 C CZ  . PHE D 1 103 ? -23.093 51.560  131.137 1.00 89.73  ? 103 PHE D CZ  1 
ATOM 4365 N N   . HIS D 1 104 ? -27.765 49.146  133.546 1.00 89.71  ? 104 HIS D N   1 
ATOM 4366 C CA  . HIS D 1 104 ? -27.902 47.912  132.773 1.00 89.71  ? 104 HIS D CA  1 
ATOM 4367 C C   . HIS D 1 104 ? -29.271 47.781  132.109 1.00 89.71  ? 104 HIS D C   1 
ATOM 4368 O O   . HIS D 1 104 ? -29.358 47.344  130.953 1.00 89.71  ? 104 HIS D O   1 
ATOM 4369 C CB  . HIS D 1 104 ? -27.612 46.704  133.659 1.00 89.71  ? 104 HIS D CB  1 
ATOM 4370 C CG  . HIS D 1 104 ? -26.158 46.523  133.963 1.00 89.71  ? 104 HIS D CG  1 
ATOM 4371 N ND1 . HIS D 1 104 ? -25.627 46.726  135.218 1.00 89.71  ? 104 HIS D ND1 1 
ATOM 4372 C CD2 . HIS D 1 104 ? -25.124 46.157  133.171 1.00 89.71  ? 104 HIS D CD2 1 
ATOM 4373 C CE1 . HIS D 1 104 ? -24.329 46.489  135.187 1.00 89.71  ? 104 HIS D CE1 1 
ATOM 4374 N NE2 . HIS D 1 104 ? -23.997 46.147  133.955 1.00 89.71  ? 104 HIS D NE2 1 
ATOM 4375 N N   . ILE D 1 105 ? -30.350 48.171  132.790 1.00 92.57  ? 105 ILE D N   1 
ATOM 4376 C CA  . ILE D 1 105 ? -31.661 48.165  132.144 1.00 92.57  ? 105 ILE D CA  1 
ATOM 4377 C C   . ILE D 1 105 ? -31.672 49.080  130.925 1.00 92.57  ? 105 ILE D C   1 
ATOM 4378 O O   . ILE D 1 105 ? -32.183 48.710  129.856 1.00 92.57  ? 105 ILE D O   1 
ATOM 4379 C CB  . ILE D 1 105 ? -32.756 48.550  133.156 1.00 92.57  ? 105 ILE D CB  1 
ATOM 4380 C CG1 . ILE D 1 105 ? -32.876 47.467  134.230 1.00 92.57  ? 105 ILE D CG1 1 
ATOM 4381 C CG2 . ILE D 1 105 ? -34.098 48.736  132.460 1.00 92.57  ? 105 ILE D CG2 1 
ATOM 4382 C CD1 . ILE D 1 105 ? -33.730 47.865  135.411 1.00 92.57  ? 105 ILE D CD1 1 
ATOM 4383 N N   . SER D 1 106 ? -31.154 50.305  131.066 1.00 92.83  ? 106 SER D N   1 
ATOM 4384 C CA  . SER D 1 106 ? -31.169 51.225  129.934 1.00 92.83  ? 106 SER D CA  1 
ATOM 4385 C C   . SER D 1 106 ? -30.324 50.709  128.778 1.00 92.83  ? 106 SER D C   1 
ATOM 4386 O O   . SER D 1 106 ? -30.726 50.816  127.613 1.00 92.83  ? 106 SER D O   1 
ATOM 4387 C CB  . SER D 1 106 ? -30.680 52.602  130.377 1.00 92.83  ? 106 SER D CB  1 
ATOM 4388 O OG  . SER D 1 106 ? -31.478 53.109  131.432 1.00 92.83  ? 106 SER D OG  1 
ATOM 4389 N N   . CYS D 1 107 ? -29.155 50.132  129.071 1.00 95.30  ? 107 CYS D N   1 
ATOM 4390 C CA  . CYS D 1 107 ? -28.345 49.547  128.006 1.00 95.30  ? 107 CYS D CA  1 
ATOM 4391 C C   . CYS D 1 107 ? -29.055 48.394  127.309 1.00 95.30  ? 107 CYS D C   1 
ATOM 4392 O O   . CYS D 1 107 ? -28.926 48.228  126.092 1.00 95.30  ? 107 CYS D O   1 
ATOM 4393 C CB  . CYS D 1 107 ? -26.994 49.086  128.555 1.00 95.30  ? 107 CYS D CB  1 
ATOM 4394 S SG  . CYS D 1 107 ? -25.908 50.424  129.102 1.00 95.30  ? 107 CYS D SG  1 
ATOM 4395 N N   . LEU D 1 108 ? -29.810 47.584  128.052 1.00 92.95  ? 108 LEU D N   1 
ATOM 4396 C CA  . LEU D 1 108 ? -30.540 46.498  127.404 1.00 92.95  ? 108 LEU D CA  1 
ATOM 4397 C C   . LEU D 1 108 ? -31.661 47.016  126.511 1.00 92.95  ? 108 LEU D C   1 
ATOM 4398 O O   . LEU D 1 108 ? -31.816 46.559  125.372 1.00 92.95  ? 108 LEU D O   1 
ATOM 4399 C CB  . LEU D 1 108 ? -31.106 45.537  128.450 1.00 92.95  ? 108 LEU D CB  1 
ATOM 4400 C CG  . LEU D 1 108 ? -30.115 44.598  129.136 1.00 92.95  ? 108 LEU D CG  1 
ATOM 4401 C CD1 . LEU D 1 108 ? -30.757 43.928  130.339 1.00 92.95  ? 108 LEU D CD1 1 
ATOM 4402 C CD2 . LEU D 1 108 ? -29.614 43.555  128.153 1.00 92.95  ? 108 LEU D CD2 1 
ATOM 4403 N N   . THR D 1 109 ? -32.458 47.967  127.001 1.00 93.94  ? 109 THR D N   1 
ATOM 4404 C CA  . THR D 1 109 ? -33.604 48.403  126.205 1.00 93.94  ? 109 THR D CA  1 
ATOM 4405 C C   . THR D 1 109 ? -33.215 49.314  125.040 1.00 93.94  ? 109 THR D C   1 
ATOM 4406 O O   . THR D 1 109 ? -33.651 49.095  123.906 1.00 93.94  ? 109 THR D O   1 
ATOM 4407 C CB  . THR D 1 109 ? -34.617 49.112  127.104 1.00 93.94  ? 109 THR D CB  1 
ATOM 4408 O OG1 . THR D 1 109 ? -35.199 48.167  128.010 1.00 93.94  ? 109 THR D OG1 1 
ATOM 4409 C CG2 . THR D 1 109 ? -35.720 49.745  126.271 1.00 93.94  ? 109 THR D CG2 1 
ATOM 4410 N N   . PHE D 1 110 ? -32.400 50.336  125.297 1.00 95.40  ? 110 PHE D N   1 
ATOM 4411 C CA  . PHE D 1 110 ? -32.017 51.303  124.271 1.00 95.40  ? 110 PHE D CA  1 
ATOM 4412 C C   . PHE D 1 110 ? -30.758 50.939  123.493 1.00 95.40  ? 110 PHE D C   1 
ATOM 4413 O O   . PHE D 1 110 ? -30.653 51.298  122.315 1.00 95.40  ? 110 PHE D O   1 
ATOM 4414 C CB  . PHE D 1 110 ? -31.891 52.690  124.897 1.00 95.40  ? 110 PHE D CB  1 
ATOM 4415 C CG  . PHE D 1 110 ? -33.179 53.183  125.490 1.00 95.40  ? 110 PHE D CG  1 
ATOM 4416 C CD1 . PHE D 1 110 ? -34.234 53.535  124.666 1.00 95.40  ? 110 PHE D CD1 1 
ATOM 4417 C CD2 . PHE D 1 110 ? -33.338 53.306  126.857 1.00 95.40  ? 110 PHE D CD2 1 
ATOM 4418 C CE1 . PHE D 1 110 ? -35.425 53.985  125.193 1.00 95.40  ? 110 PHE D CE1 1 
ATOM 4419 C CE2 . PHE D 1 110 ? -34.528 53.762  127.391 1.00 95.40  ? 110 PHE D CE2 1 
ATOM 4420 C CZ  . PHE D 1 110 ? -35.575 54.093  126.557 1.00 95.40  ? 110 PHE D CZ  1 
ATOM 4421 N N   . GLY D 1 111 ? -29.792 50.324  124.182 1.00 97.80  ? 111 GLY D N   1 
ATOM 4422 C CA  . GLY D 1 111 ? -28.477 50.048  123.572 1.00 97.80  ? 111 GLY D CA  1 
ATOM 4423 C C   . GLY D 1 111 ? -27.410 50.733  124.410 1.00 97.80  ? 111 GLY D C   1 
ATOM 4424 O O   . GLY D 1 111 ? -27.650 51.886  124.815 1.00 97.80  ? 111 GLY D O   1 
ATOM 4425 N N   . ARG D 1 112 ? -26.291 50.060  124.696 1.00 101.31 ? 112 ARG D N   1 
ATOM 4426 C CA  . ARG D 1 112 ? -25.267 50.646  125.607 1.00 101.31 ? 112 ARG D CA  1 
ATOM 4427 C C   . ARG D 1 112 ? -24.754 51.975  125.041 1.00 101.31 ? 112 ARG D C   1 
ATOM 4428 O O   . ARG D 1 112 ? -24.649 52.951  125.818 1.00 101.31 ? 112 ARG D O   1 
ATOM 4429 C CB  . ARG D 1 112 ? -24.106 49.668  125.813 1.00 101.31 ? 112 ARG D CB  1 
ATOM 4430 C CG  . ARG D 1 112 ? -23.031 50.179  126.761 1.00 101.31 ? 112 ARG D CG  1 
ATOM 4431 C CD  . ARG D 1 112 ? -21.827 49.260  126.802 1.00 101.31 ? 112 ARG D CD  1 
ATOM 4432 N NE  . ARG D 1 112 ? -21.264 49.068  125.474 1.00 101.31 ? 112 ARG D NE  1 
ATOM 4433 C CZ  . ARG D 1 112 ? -20.335 49.848  124.932 1.00 101.31 ? 112 ARG D CZ  1 
ATOM 4434 N NH1 . ARG D 1 112 ? -19.856 50.877  125.608 1.00 101.31 ? 112 ARG D NH1 1 
ATOM 4435 N NH2 . ARG D 1 112 ? -19.886 49.593  123.715 1.00 101.31 ? 112 ARG D NH2 1 
ATOM 4436 N N   . GLU D 1 113 ? -24.440 52.007  123.743 1.00 102.68 ? 113 GLU D N   1 
ATOM 4437 C CA  . GLU D 1 113 ? -23.904 53.242  123.112 1.00 102.68 ? 113 GLU D CA  1 
ATOM 4438 C C   . GLU D 1 113 ? -24.955 54.352  123.220 1.00 102.68 ? 113 GLU D C   1 
ATOM 4439 O O   . GLU D 1 113 ? -24.575 55.485  123.562 1.00 102.68 ? 113 GLU D O   1 
ATOM 4440 C CB  . GLU D 1 113 ? -23.528 52.972  121.655 1.00 102.68 ? 113 GLU D CB  1 
ATOM 4441 C CG  . GLU D 1 113 ? -22.510 51.858  121.499 1.00 102.68 ? 113 GLU D CG  1 
ATOM 4442 C CD  . GLU D 1 113 ? -22.143 51.529  120.063 1.00 102.68 ? 113 GLU D CD  1 
ATOM 4443 O OE1 . GLU D 1 113 ? -22.664 52.204  119.152 1.00 102.68 ? 113 GLU D OE1 1 
ATOM 4444 O OE2 . GLU D 1 113 ? -21.338 50.599  119.858 1.00 102.68 ? 113 GLU D OE2 1 
ATOM 4445 N N   . THR D 1 114 ? -26.222 54.025  122.950 1.00 95.37  ? 114 THR D N   1 
ATOM 4446 C CA  . THR D 1 114 ? -27.319 55.023  123.045 1.00 95.37  ? 114 THR D CA  1 
ATOM 4447 C C   . THR D 1 114 ? -27.381 55.577  124.472 1.00 95.37  ? 114 THR D C   1 
ATOM 4448 O O   . THR D 1 114 ? -27.527 56.802  124.617 1.00 95.37  ? 114 THR D O   1 
ATOM 4449 C CB  . THR D 1 114 ? -28.661 54.402  122.640 1.00 95.37  ? 114 THR D CB  1 
ATOM 4450 O OG1 . THR D 1 114 ? -28.557 53.969  121.284 1.00 95.37  ? 114 THR D OG1 1 
ATOM 4451 C CG2 . THR D 1 114 ? -29.823 55.359  122.788 1.00 95.37  ? 114 THR D CG2 1 
ATOM 4452 N N   . VAL D 1 115 ? -27.276 54.703  125.476 1.00 95.12  ? 115 VAL D N   1 
ATOM 4453 C CA  . VAL D 1 115 ? -27.344 55.134  126.905 1.00 95.12  ? 115 VAL D CA  1 
ATOM 4454 C C   . VAL D 1 115 ? -26.157 56.052  127.215 1.00 95.12  ? 115 VAL D C   1 
ATOM 4455 O O   . VAL D 1 115 ? -26.360 57.049  127.930 1.00 95.12  ? 115 VAL D O   1 
ATOM 4456 C CB  . VAL D 1 115 ? -27.370 53.918  127.849 1.00 95.12  ? 115 VAL D CB  1 
ATOM 4457 C CG1 . VAL D 1 115 ? -27.339 54.335  129.312 1.00 95.12  ? 115 VAL D CG1 1 
ATOM 4458 C CG2 . VAL D 1 115 ? -28.570 53.030  127.569 1.00 95.12  ? 115 VAL D CG2 1 
ATOM 4459 N N   . ILE D 1 116 ? -24.967 55.716  126.709 1.00 95.94  ? 116 ILE D N   1 
ATOM 4460 C CA  . ILE D 1 116 ? -23.766 56.578  126.926 1.00 95.94  ? 116 ILE D CA  1 
ATOM 4461 C C   . ILE D 1 116 ? -24.027 57.951  126.298 1.00 95.94  ? 116 ILE D C   1 
ATOM 4462 O O   . ILE D 1 116 ? -23.697 58.974  126.939 1.00 95.94  ? 116 ILE D O   1 
ATOM 4463 C CB  . ILE D 1 116 ? -22.508 55.911  126.338 1.00 30.00  ? 116 ILE D CB  1 
ATOM 4464 C CG1 . ILE D 1 116 ? -22.269 54.526  126.945 1.00 30.00  ? 116 ILE D CG1 1 
ATOM 4465 C CG2 . ILE D 1 116 ? -21.294 56.813  126.497 1.00 30.00  ? 116 ILE D CG2 1 
ATOM 4466 C CD1 . ILE D 1 116 ? -21.101 53.784  126.339 1.00 30.00  ? 116 ILE D CD1 1 
ATOM 4467 N N   . GLU D 1 117 ? -24.602 57.966  125.092 1.00 99.02  ? 117 GLU D N   1 
ATOM 4468 C CA  . GLU D 1 117 ? -24.913 59.245  124.401 1.00 99.02  ? 117 GLU D CA  1 
ATOM 4469 C C   . GLU D 1 117 ? -25.880 60.046  125.276 1.00 99.02  ? 117 GLU D C   1 
ATOM 4470 O O   . GLU D 1 117 ? -25.664 61.262  125.430 1.00 99.02  ? 117 GLU D O   1 
ATOM 4471 C CB  . GLU D 1 117 ? -25.529 58.963  123.031 1.00 99.02  ? 117 GLU D CB  1 
ATOM 4472 C CG  . GLU D 1 117 ? -24.663 58.078  122.154 1.00 99.02  ? 117 GLU D CG  1 
ATOM 4473 C CD  . GLU D 1 117 ? -25.427 57.290  121.105 1.00 99.02  ? 117 GLU D CD  1 
ATOM 4474 O OE1 . GLU D 1 117 ? -26.633 57.558  120.929 1.00 99.02  ? 117 GLU D OE1 1 
ATOM 4475 O OE2 . GLU D 1 117 ? -24.819 56.404  120.473 1.00 99.02  ? 117 GLU D OE2 1 
ATOM 4476 N N   . TYR D 1 118 ? -26.954 59.455  125.775 1.00 92.53  ? 118 TYR D N   1 
ATOM 4477 C CA  . TYR D 1 118 ? -27.835 60.198  126.696 1.00 92.53  ? 118 TYR D CA  1 
ATOM 4478 C C   . TYR D 1 118 ? -26.953 60.751  127.792 1.00 92.53  ? 118 TYR D C   1 
ATOM 4479 O O   . TYR D 1 118 ? -26.886 61.952  127.907 1.00 92.53  ? 118 TYR D O   1 
ATOM 4480 C CB  . TYR D 1 118 ? -28.926 59.352  127.330 1.00 92.53  ? 118 TYR D CB  1 
ATOM 4481 C CG  . TYR D 1 118 ? -29.598 59.997  128.511 1.00 92.53  ? 118 TYR D CG  1 
ATOM 4482 C CD1 . TYR D 1 118 ? -29.093 59.864  129.791 1.00 92.53  ? 118 TYR D CD1 1 
ATOM 4483 C CD2 . TYR D 1 118 ? -30.739 60.758  128.335 1.00 92.53  ? 118 TYR D CD2 1 
ATOM 4484 C CE1 . TYR D 1 118 ? -29.712 60.464  130.872 1.00 92.53  ? 118 TYR D CE1 1 
ATOM 4485 C CE2 . TYR D 1 118 ? -31.371 61.364  129.404 1.00 92.53  ? 118 TYR D CE2 1 
ATOM 4486 C CZ  . TYR D 1 118 ? -30.855 61.217  130.678 1.00 92.53  ? 118 TYR D CZ  1 
ATOM 4487 O OH  . TYR D 1 118 ? -31.476 61.812  131.734 1.00 92.53  ? 118 TYR D OH  1 
ATOM 4488 N N   . LEU D 1 119 ? -26.274 59.896  128.548 1.00 91.62  ? 119 LEU D N   1 
ATOM 4489 C CA  . LEU D 1 119 ? -25.496 60.407  129.706 1.00 91.62  ? 119 LEU D CA  1 
ATOM 4490 C C   . LEU D 1 119 ? -24.762 61.678  129.276 1.00 91.62  ? 119 LEU D C   1 
ATOM 4491 O O   . LEU D 1 119 ? -24.890 62.702  129.979 1.00 91.62  ? 119 LEU D O   1 
ATOM 4492 C CB  . LEU D 1 119 ? -24.495 59.331  130.136 1.00 91.62  ? 119 LEU D CB  1 
ATOM 4493 C CG  . LEU D 1 119 ? -25.107 58.027  130.645 1.00 91.62  ? 119 LEU D CG  1 
ATOM 4494 C CD1 . LEU D 1 119 ? -24.075 56.911  130.653 1.00 91.62  ? 119 LEU D CD1 1 
ATOM 4495 C CD2 . LEU D 1 119 ? -25.699 58.219  132.031 1.00 91.62  ? 119 LEU D CD2 1 
ATOM 4496 N N   . VAL D 1 120 ? -24.049 61.615  128.148 1.00 91.74  ? 120 VAL D N   1 
ATOM 4497 C CA  . VAL D 1 120 ? -23.253 62.791  127.686 1.00 91.74  ? 120 VAL D CA  1 
ATOM 4498 C C   . VAL D 1 120 ? -24.194 63.988  127.518 1.00 91.74  ? 120 VAL D C   1 
ATOM 4499 O O   . VAL D 1 120 ? -23.873 65.066  128.053 1.00 91.74  ? 120 VAL D O   1 
ATOM 4500 C CB  . VAL D 1 120 ? -22.506 62.479  126.375 1.00 91.74  ? 120 VAL D CB  1 
ATOM 4501 C CG1 . VAL D 1 120 ? -21.779 63.701  125.838 1.00 91.74  ? 120 VAL D CG1 1 
ATOM 4502 C CG2 . VAL D 1 120 ? -21.547 61.310  126.538 1.00 91.74  ? 120 VAL D CG2 1 
ATOM 4503 N N   . SER D 1 121 ? -25.323 63.794  126.830 1.00 91.09  ? 121 SER D N   1 
ATOM 4504 C CA  . SER D 1 121 ? -26.266 64.912  126.567 1.00 91.09  ? 121 SER D CA  1 
ATOM 4505 C C   . SER D 1 121 ? -26.742 65.506  127.894 1.00 91.09  ? 121 SER D C   1 
ATOM 4506 O O   . SER D 1 121 ? -26.727 66.742  128.023 1.00 91.09  ? 121 SER D O   1 
ATOM 4507 C CB  . SER D 1 121 ? -27.428 64.443  125.734 1.00 91.09  ? 121 SER D CB  1 
ATOM 4508 O OG  . SER D 1 121 ? -26.975 63.806  124.549 1.00 91.09  ? 121 SER D OG  1 
ATOM 4509 N N   . PHE D 1 122 ? -27.132 64.652  128.843 1.00 90.84  ? 122 PHE D N   1 
ATOM 4510 C CA  . PHE D 1 122 ? -27.635 65.126  130.157 1.00 90.84  ? 122 PHE D CA  1 
ATOM 4511 C C   . PHE D 1 122 ? -26.547 65.964  130.830 1.00 90.84  ? 122 PHE D C   1 
ATOM 4512 O O   . PHE D 1 122 ? -26.857 67.068  131.295 1.00 90.84  ? 122 PHE D O   1 
ATOM 4513 C CB  . PHE D 1 122 ? -28.036 63.945  131.042 1.00 90.84  ? 122 PHE D CB  1 
ATOM 4514 C CG  . PHE D 1 122 ? -28.595 64.336  132.387 1.00 90.84  ? 122 PHE D CG  1 
ATOM 4515 C CD1 . PHE D 1 122 ? -27.766 64.812  133.391 1.00 90.84  ? 122 PHE D CD1 1 
ATOM 4516 C CD2 . PHE D 1 122 ? -29.950 64.228  132.651 1.00 90.84  ? 122 PHE D CD2 1 
ATOM 4517 C CE1 . PHE D 1 122 ? -28.279 65.172  134.626 1.00 90.84  ? 122 PHE D CE1 1 
ATOM 4518 C CE2 . PHE D 1 122 ? -30.463 64.588  133.887 1.00 90.84  ? 122 PHE D CE2 1 
ATOM 4519 C CZ  . PHE D 1 122 ? -29.628 65.058  134.873 1.00 90.84  ? 122 PHE D CZ  1 
ATOM 4520 N N   . GLY D 1 123 ? -25.312 65.455  130.861 1.00 92.00  ? 123 GLY D N   1 
ATOM 4521 C CA  . GLY D 1 123 ? -24.203 66.209  131.475 1.00 92.00  ? 123 GLY D CA  1 
ATOM 4522 C C   . GLY D 1 123 ? -24.047 67.571  130.820 1.00 92.00  ? 123 GLY D C   1 
ATOM 4523 O O   . GLY D 1 123 ? -23.973 68.578  131.553 1.00 92.00  ? 123 GLY D O   1 
ATOM 4524 N N   . VAL D 1 124 ? -24.036 67.606  129.485 1.00 91.85  ? 124 VAL D N   1 
ATOM 4525 C CA  . VAL D 1 124 ? -23.845 68.891  128.750 1.00 91.85  ? 124 VAL D CA  1 
ATOM 4526 C C   . VAL D 1 124 ? -24.972 69.854  129.136 1.00 91.85  ? 124 VAL D C   1 
ATOM 4527 O O   . VAL D 1 124 ? -24.672 71.034  129.391 1.00 91.85  ? 124 VAL D O   1 
ATOM 4528 C CB  . VAL D 1 124 ? -23.808 68.661  127.227 1.00 91.85  ? 124 VAL D CB  1 
ATOM 4529 C CG1 . VAL D 1 124 ? -23.662 69.969  126.463 1.00 91.85  ? 124 VAL D CG1 1 
ATOM 4530 C CG2 . VAL D 1 124 ? -22.714 67.682  126.830 1.00 91.85  ? 124 VAL D CG2 1 
ATOM 4531 N N   . TRP D 1 125 ? -26.214 69.366  129.187 1.00 92.04  ? 125 TRP D N   1 
ATOM 4532 C CA  . TRP D 1 125 ? -27.377 70.247  129.480 1.00 92.04  ? 125 TRP D CA  1 
ATOM 4533 C C   . TRP D 1 125 ? -27.310 70.759  130.923 1.00 92.04  ? 125 TRP D C   1 
ATOM 4534 O O   . TRP D 1 125 ? -27.697 71.923  131.153 1.00 92.04  ? 125 TRP D O   1 
ATOM 4535 C CB  . TRP D 1 125 ? -28.687 69.498  129.207 1.00 92.04  ? 125 TRP D CB  1 
ATOM 4536 C CG  . TRP D 1 125 ? -29.913 70.347  129.344 1.00 92.04  ? 125 TRP D CG  1 
ATOM 4537 C CD1 . TRP D 1 125 ? -30.496 71.115  128.378 1.00 92.04  ? 125 TRP D CD1 1 
ATOM 4538 C CD2 . TRP D 1 125 ? -30.716 70.516  130.526 1.00 92.04  ? 125 TRP D CD2 1 
ATOM 4539 N NE1 . TRP D 1 125 ? -31.603 71.748  128.874 1.00 92.04  ? 125 TRP D NE1 1 
ATOM 4540 C CE2 . TRP D 1 125 ? -31.763 71.401  130.190 1.00 92.04  ? 125 TRP D CE2 1 
ATOM 4541 C CE3 . TRP D 1 125 ? -30.652 70.009  131.828 1.00 92.04  ? 125 TRP D CE3 1 
ATOM 4542 C CZ2 . TRP D 1 125 ? -32.735 71.784  131.111 1.00 92.04  ? 125 TRP D CZ2 1 
ATOM 4543 C CZ3 . TRP D 1 125 ? -31.613 70.390  132.738 1.00 92.04  ? 125 TRP D CZ3 1 
ATOM 4544 C CH2 . TRP D 1 125 ? -32.639 71.265  132.382 1.00 92.04  ? 125 TRP D CH2 1 
ATOM 4545 N N   . ILE D 1 126 ? -26.842 69.923  131.855 1.00 92.59  ? 126 ILE D N   1 
ATOM 4546 C CA  . ILE D 1 126 ? -26.830 70.317  133.295 1.00 92.59  ? 126 ILE D CA  1 
ATOM 4547 C C   . ILE D 1 126 ? -25.698 71.324  133.530 1.00 92.59  ? 126 ILE D C   1 
ATOM 4548 O O   . ILE D 1 126 ? -25.857 72.189  134.414 1.00 92.59  ? 126 ILE D O   1 
ATOM 4549 C CB  . ILE D 1 126 ? -26.712 69.079  134.208 1.00 92.59  ? 126 ILE D CB  1 
ATOM 4550 C CG1 . ILE D 1 126 ? -27.215 69.375  135.624 1.00 92.59  ? 126 ILE D CG1 1 
ATOM 4551 C CG2 . ILE D 1 126 ? -25.293 68.533  134.216 1.00 92.59  ? 126 ILE D CG2 1 
ATOM 4552 C CD1 . ILE D 1 126 ? -28.635 69.890  135.671 1.00 92.59  ? 126 ILE D CD1 1 
ATOM 4553 N N   . ARG D 1 127 ? -24.605 71.274  132.773 1.00 96.24  ? 127 ARG D N   1 
ATOM 4554 C CA  . ARG D 1 127 ? -23.558 72.297  133.021 1.00 96.24  ? 127 ARG D CA  1 
ATOM 4555 C C   . ARG D 1 127 ? -24.110 73.688  132.698 1.00 96.24  ? 127 ARG D C   1 
ATOM 4556 O O   . ARG D 1 127 ? -23.744 74.633  133.417 1.00 96.24  ? 127 ARG D O   1 
ATOM 4557 C CB  . ARG D 1 127 ? -22.289 72.005  132.214 1.00 96.24  ? 127 ARG D CB  1 
ATOM 4558 C CG  . ARG D 1 127 ? -21.509 70.797  132.715 1.00 96.24  ? 127 ARG D CG  1 
ATOM 4559 C CD  . ARG D 1 127 ? -20.126 70.682  132.106 1.00 96.24  ? 127 ARG D CD  1 
ATOM 4560 N NE  . ARG D 1 127 ? -20.158 70.470  130.667 1.00 96.24  ? 127 ARG D NE  1 
ATOM 4561 C CZ  . ARG D 1 127 ? -20.226 69.277  130.088 1.00 96.24  ? 127 ARG D CZ  1 
ATOM 4562 N NH1 . ARG D 1 127 ? -20.275 68.184  130.828 1.00 96.24  ? 127 ARG D NH1 1 
ATOM 4563 N NH2 . ARG D 1 127 ? -20.249 69.182  128.771 1.00 96.24  ? 127 ARG D NH2 1 
ATOM 4564 N N   . THR D 1 128 ? -24.959 73.819  131.674 1.00 95.98  ? 128 THR D N   1 
ATOM 4565 C CA  . THR D 1 128 ? -25.396 75.165  131.323 1.00 95.98  ? 128 THR D CA  1 
ATOM 4566 C C   . THR D 1 128 ? -26.029 75.866  132.529 1.00 95.98  ? 128 THR D C   1 
ATOM 4567 O O   . THR D 1 128 ? -26.819 75.257  133.260 1.00 95.98  ? 128 THR D O   1 
ATOM 4568 C CB  . THR D 1 128 ? -26.398 75.127  130.170 1.00 95.98  ? 128 THR D CB  1 
ATOM 4569 O OG1 . THR D 1 128 ? -25.813 74.458  129.047 1.00 95.98  ? 128 THR D OG1 1 
ATOM 4570 C CG2 . THR D 1 128 ? -26.795 76.540  129.766 1.00 95.98  ? 128 THR D CG2 1 
ATOM 4571 N N   . PRO D 1 129 ? -25.702 77.138  132.763 1.00 95.82  ? 129 PRO D N   1 
ATOM 4572 C CA  . PRO D 1 129 ? -26.311 77.860  133.880 1.00 95.82  ? 129 PRO D CA  1 
ATOM 4573 C C   . PRO D 1 129 ? -27.805 78.021  133.697 1.00 95.82  ? 129 PRO D C   1 
ATOM 4574 O O   . PRO D 1 129 ? -28.310 78.100  132.561 1.00 95.82  ? 129 PRO D O   1 
ATOM 4575 C CB  . PRO D 1 129 ? -25.592 79.218  133.855 1.00 95.82  ? 129 PRO D CB  1 
ATOM 4576 C CG  . PRO D 1 129 ? -24.325 78.972  133.142 1.00 95.82  ? 129 PRO D CG  1 
ATOM 4577 C CD  . PRO D 1 129 ? -24.651 77.938  132.115 1.00 95.82  ? 129 PRO D CD  1 
ATOM 4578 N N   . PRO D 1 130 ? -28.560 78.079  134.800 1.00 97.99  ? 130 PRO D N   1 
ATOM 4579 C CA  . PRO D 1 130 ? -30.031 78.040  134.712 1.00 97.99  ? 130 PRO D CA  1 
ATOM 4580 C C   . PRO D 1 130 ? -30.648 79.190  133.936 1.00 97.99  ? 130 PRO D C   1 
ATOM 4581 O O   . PRO D 1 130 ? -31.759 79.045  133.412 1.00 97.99  ? 130 PRO D O   1 
ATOM 4582 C CB  . PRO D 1 130 ? -30.467 78.087  136.185 1.00 97.99  ? 130 PRO D CB  1 
ATOM 4583 C CG  . PRO D 1 130 ? -29.348 78.771  136.885 1.00 97.99  ? 130 PRO D CG  1 
ATOM 4584 C CD  . PRO D 1 130 ? -28.099 78.338  136.174 1.00 97.99  ? 130 PRO D CD  1 
ATOM 4585 N N   . ALA D 1 131 ? -29.963 80.328  133.844 1.00 97.49  ? 131 ALA D N   1 
ATOM 4586 C CA  . ALA D 1 131 ? -30.454 81.444  133.043 1.00 97.49  ? 131 ALA D CA  1 
ATOM 4587 C C   . ALA D 1 131 ? -30.520 81.133  131.554 1.00 97.49  ? 131 ALA D C   1 
ATOM 4588 O O   . ALA D 1 131 ? -31.186 81.869  130.817 1.00 97.49  ? 131 ALA D O   1 
ATOM 4589 C CB  . ALA D 1 131 ? -29.572 82.673  133.268 1.00 97.49  ? 131 ALA D CB  1 
ATOM 4590 N N   . TYR D 1 132 ? -29.850 80.078  131.085 1.00 96.27  ? 132 TYR D N   1 
ATOM 4591 C CA  . TYR D 1 132 ? -29.795 79.789  129.659 1.00 96.27  ? 132 TYR D CA  1 
ATOM 4592 C C   . TYR D 1 132 ? -30.167 78.364  129.265 1.00 96.27  ? 132 TYR D C   1 
ATOM 4593 O O   . TYR D 1 132 ? -30.185 78.071  128.064 1.00 96.27  ? 132 TYR D O   1 
ATOM 4594 C CB  . TYR D 1 132 ? -28.392 80.101  129.113 1.00 96.27  ? 132 TYR D CB  1 
ATOM 4595 C CG  . TYR D 1 132 ? -27.951 81.529  129.343 1.00 96.27  ? 132 TYR D CG  1 
ATOM 4596 C CD1 . TYR D 1 132 ? -28.437 82.562  128.553 1.00 96.27  ? 132 TYR D CD1 1 
ATOM 4597 C CD2 . TYR D 1 132 ? -27.043 81.844  130.344 1.00 96.27  ? 132 TYR D CD2 1 
ATOM 4598 C CE1 . TYR D 1 132 ? -28.033 83.867  128.754 1.00 96.27  ? 132 TYR D CE1 1 
ATOM 4599 C CE2 . TYR D 1 132 ? -26.635 83.148  130.552 1.00 96.27  ? 132 TYR D CE2 1 
ATOM 4600 C CZ  . TYR D 1 132 ? -27.135 84.155  129.756 1.00 96.27  ? 132 TYR D CZ  1 
ATOM 4601 O OH  . TYR D 1 132 ? -26.739 85.455  129.967 1.00 96.27  ? 132 TYR D OH  1 
ATOM 4602 N N   . ARG D 1 133 ? -30.460 77.470  130.206 1.00 95.34  ? 133 ARG D N   1 
ATOM 4603 C CA  . ARG D 1 133 ? -30.934 76.148  129.811 1.00 95.34  ? 133 ARG D CA  1 
ATOM 4604 C C   . ARG D 1 133 ? -32.257 76.260  129.056 1.00 95.34  ? 133 ARG D C   1 
ATOM 4605 O O   . ARG D 1 133 ? -33.187 76.919  129.540 1.00 95.34  ? 133 ARG D O   1 
ATOM 4606 C CB  . ARG D 1 133 ? -31.142 75.211  131.002 1.00 95.34  ? 133 ARG D CB  1 
ATOM 4607 C CG  . ARG D 1 133 ? -29.894 74.714  131.705 1.00 95.34  ? 133 ARG D CG  1 
ATOM 4608 C CD  . ARG D 1 133 ? -30.283 73.753  132.828 1.00 95.34  ? 133 ARG D CD  1 
ATOM 4609 N NE  . ARG D 1 133 ? -30.373 74.347  134.157 1.00 95.34  ? 133 ARG D NE  1 
ATOM 4610 C CZ  . ARG D 1 133 ? -29.376 74.391  135.029 1.00 95.34  ? 133 ARG D CZ  1 
ATOM 4611 N NH1 . ARG D 1 133 ? -28.204 73.834  134.774 1.00 95.34  ? 133 ARG D NH1 1 
ATOM 4612 N NH2 . ARG D 1 133 ? -29.582 74.946  136.219 1.00 95.34  ? 133 ARG D NH2 1 
ATOM 4613 N N   . PRO D 1 134 ? -32.390 75.637  127.885 1.00 95.42  ? 134 PRO D N   1 
ATOM 4614 C CA  . PRO D 1 134 ? -33.721 75.369  127.357 1.00 95.42  ? 134 PRO D CA  1 
ATOM 4615 C C   . PRO D 1 134 ? -34.478 74.433  128.276 1.00 95.42  ? 134 PRO D C   1 
ATOM 4616 O O   . PRO D 1 134 ? -33.874 73.600  128.978 1.00 95.42  ? 134 PRO D O   1 
ATOM 4617 C CB  . PRO D 1 134 ? -33.439 74.729  125.991 1.00 95.42  ? 134 PRO D CB  1 
ATOM 4618 C CG  . PRO D 1 134 ? -32.132 74.078  126.147 1.00 95.42  ? 134 PRO D CG  1 
ATOM 4619 C CD  . PRO D 1 134 ? -31.349 74.936  127.111 1.00 95.42  ? 134 PRO D CD  1 
ATOM 4620 N N   . PRO D 1 135 ? -35.811 74.537  128.315 1.00 95.45  ? 135 PRO D N   1 
ATOM 4621 C CA  . PRO D 1 135 ? -36.581 73.703  129.251 1.00 95.45  ? 135 PRO D CA  1 
ATOM 4622 C C   . PRO D 1 135 ? -36.709 72.244  128.842 1.00 95.45  ? 135 PRO D C   1 
ATOM 4623 O O   . PRO D 1 135 ? -36.955 71.401  129.714 1.00 95.45  ? 135 PRO D O   1 
ATOM 4624 C CB  . PRO D 1 135 ? -37.953 74.389  129.273 1.00 95.45  ? 135 PRO D CB  1 
ATOM 4625 C CG  . PRO D 1 135 ? -38.082 74.960  127.904 1.00 95.45  ? 135 PRO D CG  1 
ATOM 4626 C CD  . PRO D 1 135 ? -36.689 75.406  127.514 1.00 95.45  ? 135 PRO D CD  1 
ATOM 4627 N N   . ASN D 1 136 ? -36.551 71.908  127.562 1.00 98.69  ? 136 ASN D N   1 
ATOM 4628 C CA  . ASN D 1 136 ? -36.601 70.512  127.121 1.00 98.69  ? 136 ASN D CA  1 
ATOM 4629 C C   . ASN D 1 136 ? -35.278 69.830  127.444 1.00 98.69  ? 136 ASN D C   1 
ATOM 4630 O O   . ASN D 1 136 ? -34.332 69.849  126.656 1.00 98.69  ? 136 ASN D O   1 
ATOM 4631 C CB  . ASN D 1 136 ? -36.908 70.435  125.631 1.00 98.69  ? 136 ASN D CB  1 
ATOM 4632 C CG  . ASN D 1 136 ? -38.299 70.927  125.298 1.00 98.69  ? 136 ASN D CG  1 
ATOM 4633 O OD1 . ASN D 1 136 ? -39.147 71.068  126.179 1.00 98.69  ? 136 ASN D OD1 1 
ATOM 4634 N ND2 . ASN D 1 136 ? -38.545 71.183  124.020 1.00 98.69  ? 136 ASN D ND2 1 
ATOM 4635 N N   . ALA D 1 137 ? -35.212 69.209  128.619 1.00 94.65  ? 137 ALA D N   1 
ATOM 4636 C CA  . ALA D 1 137 ? -34.092 68.338  128.934 1.00 94.65  ? 137 ALA D CA  1 
ATOM 4637 C C   . ALA D 1 137 ? -34.110 67.086  128.055 1.00 94.65  ? 137 ALA D C   1 
ATOM 4638 O O   . ALA D 1 137 ? -35.178 66.597  127.677 1.00 94.65  ? 137 ALA D O   1 
ATOM 4639 C CB  . ALA D 1 137 ? -34.127 67.937  130.404 1.00 94.65  ? 137 ALA D CB  1 
ATOM 4640 N N   . PRO D 1 138 ? -32.938 66.551  127.706 1.00 92.71  ? 138 PRO D N   1 
ATOM 4641 C CA  . PRO D 1 138 ? -32.900 65.297  126.939 1.00 92.71  ? 138 PRO D CA  1 
ATOM 4642 C C   . PRO D 1 138 ? -33.503 64.138  127.719 1.00 92.71  ? 138 PRO D C   1 
ATOM 4643 O O   . PRO D 1 138 ? -33.287 64.000  128.925 1.00 92.71  ? 138 PRO D O   1 
ATOM 4644 C CB  . PRO D 1 138 ? -31.403 65.082  126.683 1.00 92.71  ? 138 PRO D CB  1 
ATOM 4645 C CG  . PRO D 1 138 ? -30.785 66.418  126.857 1.00 92.71  ? 138 PRO D CG  1 
ATOM 4646 C CD  . PRO D 1 138 ? -31.585 67.084  127.928 1.00 92.71  ? 138 PRO D CD  1 
ATOM 4647 N N   . ILE D 1 139 ? -34.270 63.300  127.022 1.00 94.79  ? 139 ILE D N   1 
ATOM 4648 C CA  . ILE D 1 139 ? -34.701 62.017  127.566 1.00 94.79  ? 139 ILE D CA  1 
ATOM 4649 C C   . ILE D 1 139 ? -34.604 60.949  126.485 1.00 94.79  ? 139 ILE D C   1 
ATOM 4650 O O   . ILE D 1 139 ? -34.697 61.235  125.287 1.00 94.79  ? 139 ILE D O   1 
ATOM 4651 C CB  . ILE D 1 139 ? -36.137 62.079  128.136 1.00 94.79  ? 139 ILE D CB  1 
ATOM 4652 C CG1 . ILE D 1 139 ? -37.144 62.435  127.041 1.00 94.79  ? 139 ILE D CG1 1 
ATOM 4653 C CG2 . ILE D 1 139 ? -36.210 63.079  129.274 1.00 94.79  ? 139 ILE D CG2 1 
ATOM 4654 C CD1 . ILE D 1 139 ? -38.581 62.210  127.449 1.00 94.79  ? 139 ILE D CD1 1 
ATOM 4655 N N   . LEU D 1 140 ? -34.460 59.696  126.917 1.00 96.08  ? 140 LEU D N   1 
ATOM 4656 C CA  . LEU D 1 140 ? -34.348 58.546  125.987 1.00 96.08  ? 140 LEU D CA  1 
ATOM 4657 C C   . LEU D 1 140 ? -35.736 58.022  125.640 1.00 96.08  ? 140 LEU D C   1 
ATOM 4658 O O   . LEU D 1 140 ? -36.478 57.692  126.572 1.00 96.08  ? 140 LEU D O   1 
ATOM 4659 C CB  . LEU D 1 140 ? -33.525 57.444  126.659 1.00 96.08  ? 140 LEU D CB  1 
ATOM 4660 C CG  . LEU D 1 140 ? -32.017 57.669  126.714 1.00 96.08  ? 140 LEU D CG  1 
ATOM 4661 C CD1 . LEU D 1 140 ? -31.391 56.842  127.822 1.00 96.08  ? 140 LEU D CD1 1 
ATOM 4662 C CD2 . LEU D 1 140 ? -31.369 57.341  125.381 1.00 96.08  ? 140 LEU D CD2 1 
ATOM 4663 N N   . SER D 1 141 ? -36.083 57.959  124.357 1.00 116.83 ? 141 SER D N   1 
ATOM 4664 C CA  . SER D 1 141 ? -37.327 57.342  123.918 1.00 116.83 ? 141 SER D CA  1 
ATOM 4665 C C   . SER D 1 141 ? -37.147 56.828  122.498 1.00 116.83 ? 141 SER D C   1 
ATOM 4666 O O   . SER D 1 141 ? -36.221 57.224  121.786 1.00 116.83 ? 141 SER D O   1 
ATOM 4667 C CB  . SER D 1 141 ? -38.497 58.328  123.985 1.00 116.83 ? 141 SER D CB  1 
ATOM 4668 O OG  . SER D 1 141 ? -38.350 59.358  123.026 1.00 116.83 ? 141 SER D OG  1 
ATOM 4669 N N   . THR D 1 142 ? -38.050 55.934  122.100 1.00 145.22 ? 142 THR D N   1 
ATOM 4670 C CA  . THR D 1 142 ? -38.054 55.358  120.763 1.00 145.22 ? 142 THR D CA  1 
ATOM 4671 C C   . THR D 1 142 ? -39.014 56.048  119.801 1.00 145.22 ? 142 THR D C   1 
ATOM 4672 O O   . THR D 1 142 ? -39.084 55.650  118.635 1.00 145.22 ? 142 THR D O   1 
ATOM 4673 C CB  . THR D 1 142 ? -38.391 53.865  120.838 1.00 145.22 ? 142 THR D CB  1 
ATOM 4674 O OG1 . THR D 1 142 ? -38.189 53.260  119.555 1.00 145.22 ? 142 THR D OG1 1 
ATOM 4675 C CG2 . THR D 1 142 ? -39.832 53.654  121.278 1.00 145.22 ? 142 THR D CG2 1 
ATOM 4676 N N   . LEU D 1 143 ? -39.749 57.067  120.247 1.00 166.60 ? 143 LEU D N   1 
ATOM 4677 C CA  . LEU D 1 143 ? -40.879 57.556  119.474 1.00 166.60 ? 143 LEU D CA  1 
ATOM 4678 C C   . LEU D 1 143 ? -40.758 59.050  119.197 1.00 166.60 ? 143 LEU D C   1 
ATOM 4679 O O   . LEU D 1 143 ? -40.213 59.797  120.015 1.00 166.60 ? 143 LEU D O   1 
ATOM 4680 C CB  . LEU D 1 143 ? -42.203 57.301  120.207 1.00 166.60 ? 143 LEU D CB  1 
ATOM 4681 C CG  . LEU D 1 143 ? -42.619 55.849  120.449 1.00 166.60 ? 143 LEU D CG  1 
ATOM 4682 C CD1 . LEU D 1 143 ? -44.003 55.809  121.069 1.00 166.60 ? 143 LEU D CD1 1 
ATOM 4683 C CD2 . LEU D 1 143 ? -42.594 55.048  119.158 1.00 166.60 ? 143 LEU D CD2 1 
ATOM 4684 N N   . PRO D 1 144 ? -41.258 59.511  118.052 1.00 193.51 ? 144 PRO D N   1 
ATOM 4685 C CA  . PRO D 1 144 ? -41.701 60.908  117.950 1.00 193.51 ? 144 PRO D CA  1 
ATOM 4686 C C   . PRO D 1 144 ? -42.786 61.211  118.973 1.00 193.51 ? 144 PRO D C   1 
ATOM 4687 O O   . PRO D 1 144 ? -43.742 60.450  119.136 1.00 193.51 ? 144 PRO D O   1 
ATOM 4688 C CB  . PRO D 1 144 ? -42.221 61.018  116.510 1.00 193.51 ? 144 PRO D CB  1 
ATOM 4689 C CG  . PRO D 1 144 ? -41.626 59.853  115.785 1.00 193.51 ? 144 PRO D CG  1 
ATOM 4690 C CD  . PRO D 1 144 ? -41.518 58.771  116.809 1.00 193.51 ? 144 PRO D CD  1 
ATOM 4691 N N   . GLU D 1 145 ? -42.627 62.339  119.670 1.00 208.81 ? 145 GLU D N   1 
ATOM 4692 C CA  . GLU D 1 145 ? -43.547 62.681  120.752 1.00 208.81 ? 145 GLU D CA  1 
ATOM 4693 C C   . GLU D 1 145 ? -44.988 62.761  120.263 1.00 208.81 ? 145 GLU D C   1 
ATOM 4694 O O   . GLU D 1 145 ? -45.918 62.485  121.030 1.00 208.81 ? 145 GLU D O   1 
ATOM 4695 C CB  . GLU D 1 145 ? -43.133 64.008  121.386 1.00 208.81 ? 145 GLU D CB  1 
ATOM 4696 C CG  . GLU D 1 145 ? -41.741 63.997  121.995 1.00 208.81 ? 145 GLU D CG  1 
ATOM 4697 C CD  . GLU D 1 145 ? -41.409 65.291  122.711 1.00 208.81 ? 145 GLU D CD  1 
ATOM 4698 O OE1 . GLU D 1 145 ? -41.718 66.371  122.164 1.00 208.81 ? 145 GLU D OE1 1 
ATOM 4699 O OE2 . GLU D 1 145 ? -40.839 65.230  123.821 1.00 208.81 ? 145 GLU D OE2 1 
ATOM 4700 N N   . THR D 1 146 ? -45.194 63.133  119.000 1.00 215.20 ? 146 THR D N   1 
ATOM 4701 C CA  . THR D 1 146 ? -46.518 63.399  118.447 1.00 215.20 ? 146 THR D CA  1 
ATOM 4702 C C   . THR D 1 146 ? -46.979 62.288  117.505 1.00 215.20 ? 146 THR D C   1 
ATOM 4703 O O   . THR D 1 146 ? -47.770 62.533  116.591 1.00 215.20 ? 146 THR D O   1 
ATOM 4704 C CB  . THR D 1 146 ? -46.528 64.743  117.720 1.00 215.20 ? 146 THR D CB  1 
ATOM 4705 O OG1 . THR D 1 146 ? -45.536 64.740  116.686 1.00 215.20 ? 146 THR D OG1 1 
ATOM 4706 C CG2 . THR D 1 146 ? -46.244 65.881  118.691 1.00 215.20 ? 146 THR D CG2 1 
ATOM 4707 N N   . THR D 1 147 ? -46.482 61.069  117.710 1.00 212.20 ? 147 THR D N   1 
ATOM 4708 C CA  . THR D 1 147 ? -46.739 59.961  116.797 1.00 212.20 ? 147 THR D CA  1 
ATOM 4709 C C   . THR D 1 147 ? -48.225 59.826  116.490 1.00 212.20 ? 147 THR D C   1 
ATOM 4710 O O   . THR D 1 147 ? -49.053 59.707  117.398 1.00 212.20 ? 147 THR D O   1 
ATOM 4711 C CB  . THR D 1 147 ? -46.201 58.661  117.402 1.00 212.20 ? 147 THR D CB  1 
ATOM 4712 O OG1 . THR D 1 147 ? -44.769 58.672  117.369 1.00 212.20 ? 147 THR D OG1 1 
ATOM 4713 C CG2 . THR D 1 147 ? -46.712 57.445  116.633 1.00 212.20 ? 147 THR D CG2 1 
ATOM 4714 N N   . VAL D 1 148 ? -48.553 59.847  115.199 1.00 223.56 ? 148 VAL D N   1 
ATOM 4715 C CA  . VAL D 1 148 ? -49.886 59.537  114.693 1.00 223.56 ? 148 VAL D CA  1 
ATOM 4716 C C   . VAL D 1 148 ? -49.791 58.289  113.825 1.00 223.56 ? 148 VAL D C   1 
ATOM 4717 O O   . VAL D 1 148 ? -48.970 58.231  112.904 1.00 223.56 ? 148 VAL D O   1 
ATOM 4718 C CB  . VAL D 1 148 ? -50.477 60.714  113.895 1.00 223.56 ? 148 VAL D CB  1 
ATOM 4719 C CG1 . VAL D 1 148 ? -51.876 60.373  113.396 1.00 223.56 ? 148 VAL D CG1 1 
ATOM 4720 C CG2 . VAL D 1 148 ? -50.501 61.976  114.744 1.00 223.56 ? 148 VAL D CG2 1 
ATOM 4721 N N   . VAL D 1 149 ? -50.633 57.300  114.116 1.00 234.99 ? 149 VAL D N   1 
ATOM 4722 C CA  . VAL D 1 149 ? -50.822 56.136  113.254 1.00 234.99 ? 149 VAL D CA  1 
ATOM 4723 C C   . VAL D 1 149 ? -52.246 56.185  112.717 1.00 234.99 ? 149 VAL D C   1 
ATOM 4724 O O   . VAL D 1 149 ? -53.211 56.240  113.489 1.00 234.99 ? 149 VAL D O   1 
ATOM 4725 C CB  . VAL D 1 149 ? -50.556 54.824  114.008 1.00 234.99 ? 149 VAL D CB  1 
ATOM 4726 C CG1 . VAL D 1 149 ? -50.870 53.621  113.127 1.00 234.99 ? 149 VAL D CG1 1 
ATOM 4727 C CG2 . VAL D 1 149 ? -49.113 54.776  114.489 1.00 234.99 ? 149 VAL D CG2 1 
ATOM 4728 N N   . ARG D 1 150 ? -52.394 56.164  111.391 1.00 246.73 ? 150 ARG D N   1 
ATOM 4729 C CA  . ARG D 1 150 ? -53.729 56.165  110.738 1.00 246.73 ? 150 ARG D CA  1 
ATOM 4730 C C   . ARG D 1 150 ? -54.039 54.735  110.293 1.00 246.73 ? 150 ARG D C   1 
ATOM 4731 O O   . ARG D 1 150 ? -53.358 54.256  109.367 1.00 246.73 ? 150 ARG D O   1 
ATOM 4732 C CB  . ARG D 1 150 ? -53.749 57.107  109.561 1.00 246.73 ? 150 ARG D CB  1 
ATOM 4733 C CG  . ARG D 1 150 ? -55.113 57.026  108.883 1.00 246.73 ? 150 ARG D CG  1 
ATOM 4734 C CD  . ARG D 1 150 ? -55.212 58.105  107.810 1.00 246.73 ? 150 ARG D CD  1 
ATOM 4735 N NE  . ARG D 1 150 ? -55.259 59.454  108.417 1.00 246.73 ? 150 ARG D NE  1 
ATOM 4736 C CZ  . ARG D 1 150 ? -55.163 60.572  107.704 1.00 246.73 ? 150 ARG D CZ  1 
ATOM 4737 N NH1 . ARG D 1 150 ? -55.018 60.556  106.382 1.00 246.73 ? 150 ARG D NH1 1 
ATOM 4738 N NH2 . ARG D 1 150 ? -55.217 61.732  108.352 1.00 246.73 ? 150 ARG D NH2 1 
ATOM 4739 N N   . ARG D 1 151 ? -55.017 54.076  110.921 1.00 251.05 ? 151 ARG D N   1 
ATOM 4740 C CA  . ARG D 1 151 ? -55.358 52.660  110.618 1.00 251.05 ? 151 ARG D CA  1 
ATOM 4741 C C   . ARG D 1 151 ? -56.426 52.609  109.524 1.00 251.05 ? 151 ARG D C   1 
ATOM 4742 O O   . ARG D 1 151 ? -57.280 53.513  109.492 1.00 251.05 ? 151 ARG D O   1 
ATOM 4743 C CB  . ARG D 1 151 ? -55.844 51.954  111.886 1.00 251.05 ? 151 ARG D CB  1 
ATOM 4744 C CG  . ARG D 1 151 ? -56.055 50.457  111.722 1.00 251.05 ? 151 ARG D CG  1 
ATOM 4745 C CD  . ARG D 1 151 ? -54.753 49.738  111.427 1.00 251.05 ? 151 ARG D CD  1 
ATOM 4746 N NE  . ARG D 1 151 ? -54.885 48.294  111.534 1.00 251.05 ? 151 ARG D NE  1 
ATOM 4747 C CZ  . ARG D 1 151 ? -53.882 47.435  111.393 1.00 251.05 ? 151 ARG D CZ  1 
ATOM 4748 N NH1 . ARG D 1 151 ? -52.662 47.877  111.139 1.00 251.05 ? 151 ARG D NH1 1 
ATOM 4749 N NH2 . ARG D 1 151 ? -54.101 46.137  111.508 1.00 251.05 ? 151 ARG D NH2 1 
ATOM 4750 N N   . ARG D 1 152 ? -56.377 51.579  108.674 1.00 30.00  ? 152 ARG D N   1 
ATOM 4751 C CA  . ARG D 1 152 ? -57.370 51.438  107.576 1.00 30.00  ? 152 ARG D CA  1 
ATOM 4752 C C   . ARG D 1 152 ? -58.731 51.077  108.180 1.00 30.00  ? 152 ARG D C   1 
ATOM 4753 O O   . ARG D 1 152 ? -58.722 50.453  109.259 1.00 30.00  ? 152 ARG D O   1 
ATOM 4754 C CB  . ARG D 1 152 ? -56.903 50.380  106.571 1.00 30.00  ? 152 ARG D CB  1 
ATOM 4755 C CG  . ARG D 1 152 ? -57.843 50.176  105.391 1.00 30.00  ? 152 ARG D CG  1 
ATOM 4756 C CD  . ARG D 1 152 ? -57.291 49.171  104.397 1.00 30.00  ? 152 ARG D CD  1 
ATOM 4757 N NE  . ARG D 1 152 ? -57.185 47.830  104.954 1.00 30.00  ? 152 ARG D NE  1 
ATOM 4758 C CZ  . ARG D 1 152 ? -58.187 46.963  105.020 1.00 30.00  ? 152 ARG D CZ  1 
ATOM 4759 N NH1 . ARG D 1 152 ? -59.382 47.296  104.561 1.00 30.00  ? 152 ARG D NH1 1 
ATOM 4760 N NH2 . ARG D 1 152 ? -57.993 45.766  105.544 1.00 30.00  ? 152 ARG D NH2 1 
# 
