data_8UUD
# 
_entry.id   8UUD 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8UUD         pdb_00008uud 10.2210/pdb8uud/pdb 
WWPDB D_1000277083 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8UUD 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        '2ec9 contains the same proteins complexed to a similar ligand.' 
_pdbx_database_related.db_id          2ec9 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rkrishnan@biocryst.com 
_pdbx_contact_author.name_first         krishnan 
_pdbx_contact_author.name_last          raman 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6532-2567 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Krishnan, R.' 1 0000-0002-6532-2567 
'Kotian, P.'   2 0000-0002-3694-6506 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure based Drug design of human Factor VIIa Inhibitors.' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Krishnan, R.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   0000-0002-6532-2567 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Factor VII light chain' 16359.772 1   ?         ? ? ? 
2 polymer     man 'Coagulation factor VII Heavy Chain' 28103.256 1   3.4.21.21 ? ? ? 
3 polymer     man 'Tissue factor' 8715.800  1   ?         ? ? ? 
4 polymer     man 'Tissue factor' 13354.888 1   ?         ? ? ? 
5 non-polymer man beta-D-glucopyranose 180.156   1   ?         ? ? ? 
6 non-polymer man alpha-L-fucopyranose 164.156   1   ?         ? ? ? 
7 non-polymer syn 'CALCIUM ION' 40.078    9   ?         ? ? ? 
8 non-polymer syn 
;(1P)-2'-[(4-carbamimidoylphenyl)carbamoyl]-4'-ethenyl-4-[(2-methylpropyl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid
;
484.546   1   ?         ? ? ? 
9 water       nat water 18.015    121 ?         ? ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        'Proconvertin,Serum prothrombin conversion accelerator,SPCA' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes 
;ANAFL(CGU)(CGU)LRPGSL(CGU)R(CGU)CK(CGU)(CGU)QCSF(CGU)(CGU)AR(CGU)IFKDA(CGU)RTKLF
WISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILE
;
;ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRN
CETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
;
L ? 
2 'polypeptide(L)' no no  
;IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQ
QSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMR
SEPRPGVLLRAPFP
;
;IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQ
QSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMR
SEPRPGVLLRAPFP
;
H ? 
3 'polypeptide(L)' no no  TVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPA 
TVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPA T ? 
4 'polypeptide(L)' no no  
;EPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWSGKKTAKTNTNE
FLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECM
;
;EPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWSGKKTAKTNTNE
FLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECM
;
U ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
5 beta-D-glucopyranose                                                                                                   BGC 
6 alpha-L-fucopyranose                                                                                                   FUC 
7 'CALCIUM ION'                                                                                                          CA  
8 
;(1P)-2'-[(4-carbamimidoylphenyl)carbamoyl]-4'-ethenyl-4-[(2-methylpropyl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid
;
XGX 
9 water                                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   ASN n 
1 3   ALA n 
1 4   PHE n 
1 5   LEU n 
1 6   CGU n 
1 7   CGU n 
1 8   LEU n 
1 9   ARG n 
1 10  PRO n 
1 11  GLY n 
1 12  SER n 
1 13  LEU n 
1 14  CGU n 
1 15  ARG n 
1 16  CGU n 
1 17  CYS n 
1 18  LYS n 
1 19  CGU n 
1 20  CGU n 
1 21  GLN n 
1 22  CYS n 
1 23  SER n 
1 24  PHE n 
1 25  CGU n 
1 26  CGU n 
1 27  ALA n 
1 28  ARG n 
1 29  CGU n 
1 30  ILE n 
1 31  PHE n 
1 32  LYS n 
1 33  ASP n 
1 34  ALA n 
1 35  CGU n 
1 36  ARG n 
1 37  THR n 
1 38  LYS n 
1 39  LEU n 
1 40  PHE n 
1 41  TRP n 
1 42  ILE n 
1 43  SER n 
1 44  TYR n 
1 45  SER n 
1 46  ASP n 
1 47  GLY n 
1 48  ASP n 
1 49  GLN n 
1 50  CYS n 
1 51  ALA n 
1 52  SER n 
1 53  SER n 
1 54  PRO n 
1 55  CYS n 
1 56  GLN n 
1 57  ASN n 
1 58  GLY n 
1 59  GLY n 
1 60  SER n 
1 61  CYS n 
1 62  LYS n 
1 63  ASP n 
1 64  GLN n 
1 65  LEU n 
1 66  GLN n 
1 67  SER n 
1 68  TYR n 
1 69  ILE n 
1 70  CYS n 
1 71  PHE n 
1 72  CYS n 
1 73  LEU n 
1 74  PRO n 
1 75  ALA n 
1 76  PHE n 
1 77  GLU n 
1 78  GLY n 
1 79  ARG n 
1 80  ASN n 
1 81  CYS n 
1 82  GLU n 
1 83  THR n 
1 84  HIS n 
1 85  LYS n 
1 86  ASP n 
1 87  ASP n 
1 88  GLN n 
1 89  LEU n 
1 90  ILE n 
1 91  CYS n 
1 92  VAL n 
1 93  ASN n 
1 94  GLU n 
1 95  ASN n 
1 96  GLY n 
1 97  GLY n 
1 98  CYS n 
1 99  GLU n 
1 100 GLN n 
1 101 TYR n 
1 102 CYS n 
1 103 SER n 
1 104 ASP n 
1 105 HIS n 
1 106 THR n 
1 107 GLY n 
1 108 THR n 
1 109 LYS n 
1 110 ARG n 
1 111 SER n 
1 112 CYS n 
1 113 ARG n 
1 114 CYS n 
1 115 HIS n 
1 116 GLU n 
1 117 GLY n 
1 118 TYR n 
1 119 SER n 
1 120 LEU n 
1 121 LEU n 
1 122 ALA n 
1 123 ASP n 
1 124 GLY n 
1 125 VAL n 
1 126 SER n 
1 127 CYS n 
1 128 THR n 
1 129 PRO n 
1 130 THR n 
1 131 VAL n 
1 132 GLU n 
1 133 TYR n 
1 134 PRO n 
1 135 CYS n 
1 136 GLY n 
1 137 LYS n 
1 138 ILE n 
1 139 PRO n 
1 140 ILE n 
1 141 LEU n 
1 142 GLU n 
2 1   ILE n 
2 2   VAL n 
2 3   GLY n 
2 4   GLY n 
2 5   LYS n 
2 6   VAL n 
2 7   CYS n 
2 8   PRO n 
2 9   LYS n 
2 10  GLY n 
2 11  GLU n 
2 12  CYS n 
2 13  PRO n 
2 14  TRP n 
2 15  GLN n 
2 16  VAL n 
2 17  LEU n 
2 18  LEU n 
2 19  LEU n 
2 20  VAL n 
2 21  ASN n 
2 22  GLY n 
2 23  ALA n 
2 24  GLN n 
2 25  LEU n 
2 26  CYS n 
2 27  GLY n 
2 28  GLY n 
2 29  THR n 
2 30  LEU n 
2 31  ILE n 
2 32  ASN n 
2 33  THR n 
2 34  ILE n 
2 35  TRP n 
2 36  VAL n 
2 37  VAL n 
2 38  SER n 
2 39  ALA n 
2 40  ALA n 
2 41  HIS n 
2 42  CYS n 
2 43  PHE n 
2 44  ASP n 
2 45  LYS n 
2 46  ILE n 
2 47  LYS n 
2 48  ASN n 
2 49  TRP n 
2 50  ARG n 
2 51  ASN n 
2 52  LEU n 
2 53  ILE n 
2 54  ALA n 
2 55  VAL n 
2 56  LEU n 
2 57  GLY n 
2 58  GLU n 
2 59  HIS n 
2 60  ASP n 
2 61  LEU n 
2 62  SER n 
2 63  GLU n 
2 64  HIS n 
2 65  ASP n 
2 66  GLY n 
2 67  ASP n 
2 68  GLU n 
2 69  GLN n 
2 70  SER n 
2 71  ARG n 
2 72  ARG n 
2 73  VAL n 
2 74  ALA n 
2 75  GLN n 
2 76  VAL n 
2 77  ILE n 
2 78  ILE n 
2 79  PRO n 
2 80  SER n 
2 81  THR n 
2 82  TYR n 
2 83  VAL n 
2 84  PRO n 
2 85  GLY n 
2 86  THR n 
2 87  THR n 
2 88  ASN n 
2 89  HIS n 
2 90  ASP n 
2 91  ILE n 
2 92  ALA n 
2 93  LEU n 
2 94  LEU n 
2 95  ARG n 
2 96  LEU n 
2 97  HIS n 
2 98  GLN n 
2 99  PRO n 
2 100 VAL n 
2 101 VAL n 
2 102 LEU n 
2 103 THR n 
2 104 ASP n 
2 105 HIS n 
2 106 VAL n 
2 107 VAL n 
2 108 PRO n 
2 109 LEU n 
2 110 CYS n 
2 111 LEU n 
2 112 PRO n 
2 113 GLU n 
2 114 ARG n 
2 115 THR n 
2 116 PHE n 
2 117 SER n 
2 118 GLU n 
2 119 ARG n 
2 120 THR n 
2 121 LEU n 
2 122 ALA n 
2 123 PHE n 
2 124 VAL n 
2 125 ARG n 
2 126 PHE n 
2 127 SER n 
2 128 LEU n 
2 129 VAL n 
2 130 SER n 
2 131 GLY n 
2 132 TRP n 
2 133 GLY n 
2 134 GLN n 
2 135 LEU n 
2 136 LEU n 
2 137 ASP n 
2 138 ARG n 
2 139 GLY n 
2 140 ALA n 
2 141 THR n 
2 142 ALA n 
2 143 LEU n 
2 144 GLU n 
2 145 LEU n 
2 146 MET n 
2 147 VAL n 
2 148 LEU n 
2 149 ASN n 
2 150 VAL n 
2 151 PRO n 
2 152 ARG n 
2 153 LEU n 
2 154 MET n 
2 155 THR n 
2 156 GLN n 
2 157 ASP n 
2 158 CYS n 
2 159 LEU n 
2 160 GLN n 
2 161 GLN n 
2 162 SER n 
2 163 ARG n 
2 164 LYS n 
2 165 VAL n 
2 166 GLY n 
2 167 ASP n 
2 168 SER n 
2 169 PRO n 
2 170 ASN n 
2 171 ILE n 
2 172 THR n 
2 173 GLU n 
2 174 TYR n 
2 175 MET n 
2 176 PHE n 
2 177 CYS n 
2 178 ALA n 
2 179 GLY n 
2 180 TYR n 
2 181 SER n 
2 182 ASP n 
2 183 GLY n 
2 184 SER n 
2 185 LYS n 
2 186 ASP n 
2 187 SER n 
2 188 CYS n 
2 189 LYS n 
2 190 GLY n 
2 191 ASP n 
2 192 SER n 
2 193 GLY n 
2 194 GLY n 
2 195 PRO n 
2 196 HIS n 
2 197 ALA n 
2 198 THR n 
2 199 HIS n 
2 200 TYR n 
2 201 ARG n 
2 202 GLY n 
2 203 THR n 
2 204 TRP n 
2 205 TYR n 
2 206 LEU n 
2 207 THR n 
2 208 GLY n 
2 209 ILE n 
2 210 VAL n 
2 211 SER n 
2 212 TRP n 
2 213 GLY n 
2 214 GLN n 
2 215 GLY n 
2 216 CYS n 
2 217 ALA n 
2 218 THR n 
2 219 VAL n 
2 220 GLY n 
2 221 HIS n 
2 222 PHE n 
2 223 GLY n 
2 224 VAL n 
2 225 TYR n 
2 226 THR n 
2 227 ARG n 
2 228 VAL n 
2 229 SER n 
2 230 GLN n 
2 231 TYR n 
2 232 ILE n 
2 233 GLU n 
2 234 TRP n 
2 235 LEU n 
2 236 GLN n 
2 237 LYS n 
2 238 LEU n 
2 239 MET n 
2 240 ARG n 
2 241 SER n 
2 242 GLU n 
2 243 PRO n 
2 244 ARG n 
2 245 PRO n 
2 246 GLY n 
2 247 VAL n 
2 248 LEU n 
2 249 LEU n 
2 250 ARG n 
2 251 ALA n 
2 252 PRO n 
2 253 PHE n 
2 254 PRO n 
3 1   THR n 
3 2   VAL n 
3 3   ALA n 
3 4   ALA n 
3 5   TYR n 
3 6   ASN n 
3 7   LEU n 
3 8   THR n 
3 9   TRP n 
3 10  LYS n 
3 11  SER n 
3 12  THR n 
3 13  ASN n 
3 14  PHE n 
3 15  LYS n 
3 16  THR n 
3 17  ILE n 
3 18  LEU n 
3 19  GLU n 
3 20  TRP n 
3 21  GLU n 
3 22  PRO n 
3 23  LYS n 
3 24  PRO n 
3 25  VAL n 
3 26  ASN n 
3 27  GLN n 
3 28  VAL n 
3 29  TYR n 
3 30  THR n 
3 31  VAL n 
3 32  GLN n 
3 33  ILE n 
3 34  SER n 
3 35  THR n 
3 36  LYS n 
3 37  SER n 
3 38  GLY n 
3 39  ASP n 
3 40  TRP n 
3 41  LYS n 
3 42  SER n 
3 43  LYS n 
3 44  CYS n 
3 45  PHE n 
3 46  TYR n 
3 47  THR n 
3 48  THR n 
3 49  ASP n 
3 50  THR n 
3 51  GLU n 
3 52  CYS n 
3 53  ASP n 
3 54  LEU n 
3 55  THR n 
3 56  ASP n 
3 57  GLU n 
3 58  ILE n 
3 59  VAL n 
3 60  LYS n 
3 61  ASP n 
3 62  VAL n 
3 63  LYS n 
3 64  GLN n 
3 65  THR n 
3 66  TYR n 
3 67  LEU n 
3 68  ALA n 
3 69  ARG n 
3 70  VAL n 
3 71  PHE n 
3 72  SER n 
3 73  TYR n 
3 74  PRO n 
3 75  ALA n 
4 1   GLU n 
4 2   PRO n 
4 3   LEU n 
4 4   TYR n 
4 5   GLU n 
4 6   ASN n 
4 7   SER n 
4 8   PRO n 
4 9   GLU n 
4 10  PHE n 
4 11  THR n 
4 12  PRO n 
4 13  TYR n 
4 14  LEU n 
4 15  GLU n 
4 16  THR n 
4 17  ASN n 
4 18  LEU n 
4 19  GLY n 
4 20  GLN n 
4 21  PRO n 
4 22  THR n 
4 23  ILE n 
4 24  GLN n 
4 25  SER n 
4 26  PHE n 
4 27  GLU n 
4 28  GLN n 
4 29  VAL n 
4 30  GLY n 
4 31  THR n 
4 32  LYS n 
4 33  VAL n 
4 34  ASN n 
4 35  VAL n 
4 36  THR n 
4 37  VAL n 
4 38  GLU n 
4 39  ASP n 
4 40  GLU n 
4 41  ARG n 
4 42  THR n 
4 43  LEU n 
4 44  VAL n 
4 45  ARG n 
4 46  ARG n 
4 47  ASN n 
4 48  ASN n 
4 49  THR n 
4 50  PHE n 
4 51  LEU n 
4 52  SER n 
4 53  LEU n 
4 54  ARG n 
4 55  ASP n 
4 56  VAL n 
4 57  PHE n 
4 58  GLY n 
4 59  LYS n 
4 60  ASP n 
4 61  LEU n 
4 62  ILE n 
4 63  TYR n 
4 64  THR n 
4 65  LEU n 
4 66  TYR n 
4 67  TYR n 
4 68  TRP n 
4 69  SER n 
4 70  GLY n 
4 71  LYS n 
4 72  LYS n 
4 73  THR n 
4 74  ALA n 
4 75  LYS n 
4 76  THR n 
4 77  ASN n 
4 78  THR n 
4 79  ASN n 
4 80  GLU n 
4 81  PHE n 
4 82  LEU n 
4 83  ILE n 
4 84  ASP n 
4 85  VAL n 
4 86  ASP n 
4 87  LYS n 
4 88  GLY n 
4 89  GLU n 
4 90  ASN n 
4 91  TYR n 
4 92  CYS n 
4 93  PHE n 
4 94  SER n 
4 95  VAL n 
4 96  GLN n 
4 97  ALA n 
4 98  VAL n 
4 99  ILE n 
4 100 PRO n 
4 101 SER n 
4 102 ARG n 
4 103 THR n 
4 104 VAL n 
4 105 ASN n 
4 106 ARG n 
4 107 LYS n 
4 108 SER n 
4 109 THR n 
4 110 ASP n 
4 111 SER n 
4 112 PRO n 
4 113 VAL n 
4 114 GLU n 
4 115 CYS n 
4 116 MET n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 142 human ? F7 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? Cricetinae                 10026 
? ? ? ? ? ? ? ? BHK ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 254 human ? F7 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? Cricetinae                 10026 
? ? ? ? ? ? ? ? bhk ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 75  human ? F3 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'unidentified baculovirus' 10469 
? ? ? ? ? ? ? ? ?   ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 116 human ? F3 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'unidentified baculovirus' 10469 
? ? ? ? ? ? ? ? ?   ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE ?                                                                   'C3 H7 N O2'     
89.093  
ARG 'L-peptide linking'           y ARGININE ?                                                                   'C6 H15 N4 O2 1' 
175.209 
ASN 'L-peptide linking'           y ASPARAGINE ?                                                                   'C4 H8 N2 O3' 
132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID' ?                                                                   
'C4 H7 N O4'     133.103 
BGC 'D-saccharide, beta linking'  . beta-D-glucopyranose 'beta-D-glucose; D-glucose; glucose'                                
'C6 H12 O6'      180.156 
CA  non-polymer                   . 'CALCIUM ION' ?                                                                   'Ca 2' 
40.078  
CGU 'L-peptide linking'           n 'GAMMA-CARBOXY-GLUTAMIC ACID' ? 'C6 H9 N O6'     191.139 
CYS 'L-peptide linking'           y CYSTEINE ?                                                                   'C3 H7 N O2 S'   
121.158 
FUC 'L-saccharide, alpha linking' . alpha-L-fucopyranose 'alpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose' 
'C6 H12 O5'      164.156 
GLN 'L-peptide linking'           y GLUTAMINE ?                                                                   'C5 H10 N2 O3'   
146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID' ?                                                                   
'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE ?                                                                   'C2 H5 N O2'     
75.067  
HIS 'L-peptide linking'           y HISTIDINE ?                                                                   'C6 H10 N3 O2 1' 
156.162 
HOH non-polymer                   . WATER ?                                                                   'H2 O'           
18.015  
ILE 'L-peptide linking'           y ISOLEUCINE ?                                                                   'C6 H13 N O2' 
131.173 
LEU 'L-peptide linking'           y LEUCINE ?                                                                   'C6 H13 N O2'    
131.173 
LYS 'L-peptide linking'           y LYSINE ?                                                                   'C6 H15 N2 O2 1' 
147.195 
MET 'L-peptide linking'           y METHIONINE ?                                                                   'C5 H11 N O2 S' 
149.211 
PHE 'L-peptide linking'           y PHENYLALANINE ?                                                                   
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE ?                                                                   'C5 H9 N O2'     
115.130 
SER 'L-peptide linking'           y SERINE ?                                                                   'C3 H7 N O3'     
105.093 
THR 'L-peptide linking'           y THREONINE ?                                                                   'C4 H9 N O3'     
119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN ?                                                                   'C11 H12 N2 O2' 
204.225 
TYR 'L-peptide linking'           y TYROSINE ?                                                                   'C9 H11 N O3'    
181.189 
VAL 'L-peptide linking'           y VALINE ?                                                                   'C5 H11 N O2'    
117.146 
XGX non-polymer                   . 
;(1P)-2'-[(4-carbamimidoylphenyl)carbamoyl]-4'-ethenyl-4-[(2-methylpropyl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid
;
BCX2627                                                             'C28 H28 N4 O4'  484.546 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BGC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpb            
BGC 'COMMON NAME'                         GMML     1.0 b-D-glucopyranose 
BGC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Glcp          
BGC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Glc               
FUC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 LFucpa            
FUC 'COMMON NAME'                         GMML     1.0 a-L-fucopyranose  
FUC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-L-Fucp          
FUC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Fuc               
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   1   1   ALA ALA L . n 
A 1 2   ASN 2   2   2   ASN ASN L . n 
A 1 3   ALA 3   3   3   ALA ALA L . n 
A 1 4   PHE 4   4   4   PHE PHE L . n 
A 1 5   LEU 5   5   5   LEU LEU L . n 
A 1 6   CGU 6   6   6   CGU CGU L . n 
A 1 7   CGU 7   7   7   CGU CGU L . n 
A 1 8   LEU 8   8   8   LEU LEU L . n 
A 1 9   ARG 9   9   9   ARG ARG L . n 
A 1 10  PRO 10  10  10  PRO PRO L . n 
A 1 11  GLY 11  11  11  GLY GLY L . n 
A 1 12  SER 12  12  12  SER SER L . n 
A 1 13  LEU 13  13  13  LEU LEU L . n 
A 1 14  CGU 14  14  14  CGU CGU L . n 
A 1 15  ARG 15  15  15  ARG ARG L . n 
A 1 16  CGU 16  16  16  CGU CGU L . n 
A 1 17  CYS 17  17  17  CYS CYS L . n 
A 1 18  LYS 18  18  18  LYS LYS L . n 
A 1 19  CGU 19  19  19  CGU CGU L . n 
A 1 20  CGU 20  20  20  CGU CGU L . n 
A 1 21  GLN 21  21  21  GLN GLN L . n 
A 1 22  CYS 22  22  22  CYS CYS L . n 
A 1 23  SER 23  23  23  SER SER L . n 
A 1 24  PHE 24  24  24  PHE PHE L . n 
A 1 25  CGU 25  25  25  CGU CGU L . n 
A 1 26  CGU 26  26  26  CGU CGU L . n 
A 1 27  ALA 27  27  27  ALA ALA L . n 
A 1 28  ARG 28  28  28  ARG ARG L . n 
A 1 29  CGU 29  29  29  CGU CGU L . n 
A 1 30  ILE 30  30  30  ILE ILE L . n 
A 1 31  PHE 31  31  31  PHE PHE L . n 
A 1 32  LYS 32  32  32  LYS LYS L . n 
A 1 33  ASP 33  33  33  ASP ASP L . n 
A 1 34  ALA 34  34  34  ALA ALA L . n 
A 1 35  CGU 35  35  35  CGU CGU L . n 
A 1 36  ARG 36  36  36  ARG ARG L . n 
A 1 37  THR 37  37  37  THR THR L . n 
A 1 38  LYS 38  38  38  LYS LYS L . n 
A 1 39  LEU 39  39  39  LEU LEU L . n 
A 1 40  PHE 40  40  40  PHE PHE L . n 
A 1 41  TRP 41  41  41  TRP TRP L . n 
A 1 42  ILE 42  42  42  ILE ILE L . n 
A 1 43  SER 43  43  43  SER SER L . n 
A 1 44  TYR 44  44  44  TYR TYR L . n 
A 1 45  SER 45  45  45  SER SER L . n 
A 1 46  ASP 46  46  46  ASP ASP L . n 
A 1 47  GLY 47  47  47  GLY GLY L . n 
A 1 48  ASP 48  48  48  ASP ASP L . n 
A 1 49  GLN 49  49  49  GLN GLN L . n 
A 1 50  CYS 50  50  50  CYS CYS L . n 
A 1 51  ALA 51  51  51  ALA ALA L . n 
A 1 52  SER 52  52  52  SER SER L . n 
A 1 53  SER 53  53  53  SER SER L . n 
A 1 54  PRO 54  54  54  PRO PRO L . n 
A 1 55  CYS 55  55  55  CYS CYS L . n 
A 1 56  GLN 56  56  56  GLN GLN L . n 
A 1 57  ASN 57  57  57  ASN ASN L . n 
A 1 58  GLY 58  58  58  GLY GLY L . n 
A 1 59  GLY 59  59  59  GLY GLY L . n 
A 1 60  SER 60  60  60  SER SER L . n 
A 1 61  CYS 61  61  61  CYS CYS L . n 
A 1 62  LYS 62  62  62  LYS LYS L . n 
A 1 63  ASP 63  63  63  ASP ASP L . n 
A 1 64  GLN 64  64  64  GLN GLN L . n 
A 1 65  LEU 65  65  65  LEU LEU L . n 
A 1 66  GLN 66  66  66  GLN GLN L . n 
A 1 67  SER 67  67  67  SER SER L . n 
A 1 68  TYR 68  68  68  TYR TYR L . n 
A 1 69  ILE 69  69  69  ILE ILE L . n 
A 1 70  CYS 70  70  70  CYS CYS L . n 
A 1 71  PHE 71  71  71  PHE PHE L . n 
A 1 72  CYS 72  72  72  CYS CYS L . n 
A 1 73  LEU 73  73  73  LEU LEU L . n 
A 1 74  PRO 74  74  74  PRO PRO L . n 
A 1 75  ALA 75  75  75  ALA ALA L . n 
A 1 76  PHE 76  76  76  PHE PHE L . n 
A 1 77  GLU 77  77  77  GLU GLU L . n 
A 1 78  GLY 78  78  78  GLY GLY L . n 
A 1 79  ARG 79  79  79  ARG ARG L . n 
A 1 80  ASN 80  80  80  ASN ASN L . n 
A 1 81  CYS 81  81  81  CYS CYS L . n 
A 1 82  GLU 82  82  82  GLU GLU L . n 
A 1 83  THR 83  83  83  THR THR L . n 
A 1 84  HIS 84  84  84  HIS HIS L . n 
A 1 85  LYS 85  85  85  LYS LYS L . n 
A 1 86  ASP 86  86  86  ASP ASP L . n 
A 1 87  ASP 87  87  87  ASP ASP L . n 
A 1 88  GLN 88  88  88  GLN GLN L . n 
A 1 89  LEU 89  89  89  LEU LEU L . n 
A 1 90  ILE 90  90  90  ILE ILE L . n 
A 1 91  CYS 91  91  91  CYS CYS L . n 
A 1 92  VAL 92  92  92  VAL VAL L . n 
A 1 93  ASN 93  93  93  ASN ASN L . n 
A 1 94  GLU 94  94  94  GLU GLU L . n 
A 1 95  ASN 95  95  95  ASN ASN L . n 
A 1 96  GLY 96  96  96  GLY GLY L . n 
A 1 97  GLY 97  97  97  GLY GLY L . n 
A 1 98  CYS 98  98  98  CYS CYS L . n 
A 1 99  GLU 99  99  99  GLU GLU L . n 
A 1 100 GLN 100 100 100 GLN GLN L . n 
A 1 101 TYR 101 101 101 TYR TYR L . n 
A 1 102 CYS 102 102 102 CYS CYS L . n 
A 1 103 SER 103 103 103 SER SER L . n 
A 1 104 ASP 104 104 104 ASP ASP L . n 
A 1 105 HIS 105 105 105 HIS HIS L . n 
A 1 106 THR 106 106 106 THR THR L . n 
A 1 107 GLY 107 107 107 GLY GLY L . n 
A 1 108 THR 108 108 108 THR THR L . n 
A 1 109 LYS 109 109 109 LYS LYS L . n 
A 1 110 ARG 110 110 110 ARG ARG L . n 
A 1 111 SER 111 111 111 SER SER L . n 
A 1 112 CYS 112 112 112 CYS CYS L . n 
A 1 113 ARG 113 113 113 ARG ARG L . n 
A 1 114 CYS 114 114 114 CYS CYS L . n 
A 1 115 HIS 115 115 115 HIS HIS L . n 
A 1 116 GLU 116 116 116 GLU GLU L . n 
A 1 117 GLY 117 117 117 GLY GLY L . n 
A 1 118 TYR 118 118 118 TYR TYR L . n 
A 1 119 SER 119 119 119 SER SER L . n 
A 1 120 LEU 120 120 120 LEU LEU L . n 
A 1 121 LEU 121 121 121 LEU LEU L . n 
A 1 122 ALA 122 122 122 ALA ALA L . n 
A 1 123 ASP 123 123 123 ASP ASP L . n 
A 1 124 GLY 124 124 124 GLY GLY L . n 
A 1 125 VAL 125 125 125 VAL VAL L . n 
A 1 126 SER 126 126 126 SER SER L . n 
A 1 127 CYS 127 127 127 CYS CYS L . n 
A 1 128 THR 128 128 128 THR THR L . n 
A 1 129 PRO 129 129 129 PRO PRO L . n 
A 1 130 THR 130 130 130 THR THR L . n 
A 1 131 VAL 131 131 131 VAL VAL L . n 
A 1 132 GLU 132 132 132 GLU GLU L . n 
A 1 133 TYR 133 133 133 TYR TYR L . n 
A 1 134 PRO 134 134 134 PRO PRO L . n 
A 1 135 CYS 135 135 135 CYS CYS L . n 
A 1 136 GLY 136 136 136 GLY GLY L . n 
A 1 137 LYS 137 137 137 LYS LYS L . n 
A 1 138 ILE 138 138 138 ILE ILE L . n 
A 1 139 PRO 139 139 139 PRO PRO L . n 
A 1 140 ILE 140 140 140 ILE ILE L . n 
A 1 141 LEU 141 141 141 LEU LEU L . n 
A 1 142 GLU 142 142 142 GLU GLU L . n 
B 2 1   ILE 1   16  16  ILE ILE H . n 
B 2 2   VAL 2   17  17  VAL VAL H . n 
B 2 3   GLY 3   18  18  GLY GLY H . n 
B 2 4   GLY 4   19  19  GLY GLY H . n 
B 2 5   LYS 5   20  20  LYS LYS H . n 
B 2 6   VAL 6   21  21  VAL VAL H . n 
B 2 7   CYS 7   22  22  CYS CYS H . n 
B 2 8   PRO 8   23  23  PRO PRO H . n 
B 2 9   LYS 9   24  24  LYS LYS H . n 
B 2 10  GLY 10  25  25  GLY GLY H . n 
B 2 11  GLU 11  26  26  GLU GLU H . n 
B 2 12  CYS 12  27  27  CYS CYS H . n 
B 2 13  PRO 13  28  28  PRO PRO H . n 
B 2 14  TRP 14  29  29  TRP TRP H . n 
B 2 15  GLN 15  30  30  GLN GLN H . n 
B 2 16  VAL 16  31  31  VAL VAL H . n 
B 2 17  LEU 17  32  32  LEU LEU H . n 
B 2 18  LEU 18  33  33  LEU LEU H . n 
B 2 19  LEU 19  34  34  LEU LEU H . n 
B 2 20  VAL 20  35  35  VAL VAL H . n 
B 2 21  ASN 21  36  36  ASN ASN H . n 
B 2 22  GLY 22  37  37  GLY GLY H . n 
B 2 23  ALA 23  38  38  ALA ALA H . n 
B 2 24  GLN 24  39  39  GLN GLN H . n 
B 2 25  LEU 25  40  40  LEU LEU H . n 
B 2 26  CYS 26  41  41  CYS CYS H . n 
B 2 27  GLY 27  42  42  GLY GLY H . n 
B 2 28  GLY 28  43  43  GLY GLY H . n 
B 2 29  THR 29  44  44  THR THR H . n 
B 2 30  LEU 30  45  45  LEU LEU H . n 
B 2 31  ILE 31  46  46  ILE ILE H . n 
B 2 32  ASN 32  47  47  ASN ASN H . n 
B 2 33  THR 33  48  48  THR THR H . n 
B 2 34  ILE 34  49  49  ILE ILE H . n 
B 2 35  TRP 35  50  50  TRP TRP H . n 
B 2 36  VAL 36  51  51  VAL VAL H . n 
B 2 37  VAL 37  52  52  VAL VAL H . n 
B 2 38  SER 38  53  53  SER SER H . n 
B 2 39  ALA 39  54  54  ALA ALA H . n 
B 2 40  ALA 40  55  55  ALA ALA H . n 
B 2 41  HIS 41  56  56  HIS HIS H . n 
B 2 42  CYS 42  57  57  CYS CYS H . n 
B 2 43  PHE 43  58  58  PHE PHE H . n 
B 2 44  ASP 44  59  59  ASP ASP H . n 
B 2 45  LYS 45  60  60  LYS LYS H . n 
B 2 46  ILE 46  61  61  ILE ILE H . n 
B 2 47  LYS 47  62  62  LYS LYS H . n 
B 2 48  ASN 48  63  63  ASN ASN H . n 
B 2 49  TRP 49  64  64  TRP TRP H . n 
B 2 50  ARG 50  65  65  ARG ARG H . n 
B 2 51  ASN 51  66  66  ASN ASN H . n 
B 2 52  LEU 52  67  67  LEU LEU H . n 
B 2 53  ILE 53  68  68  ILE ILE H . n 
B 2 54  ALA 54  69  69  ALA ALA H . n 
B 2 55  VAL 55  70  70  VAL VAL H . n 
B 2 56  LEU 56  71  71  LEU LEU H . n 
B 2 57  GLY 57  72  72  GLY GLY H . n 
B 2 58  GLU 58  73  73  GLU GLU H . n 
B 2 59  HIS 59  74  74  HIS HIS H . n 
B 2 60  ASP 60  75  75  ASP ASP H . n 
B 2 61  LEU 61  76  76  LEU LEU H . n 
B 2 62  SER 62  77  77  SER SER H . n 
B 2 63  GLU 63  78  78  GLU GLU H . n 
B 2 64  HIS 64  79  79  HIS HIS H . n 
B 2 65  ASP 65  80  80  ASP ASP H . n 
B 2 66  GLY 66  81  81  GLY GLY H . n 
B 2 67  ASP 67  82  82  ASP ASP H . n 
B 2 68  GLU 68  83  83  GLU GLU H . n 
B 2 69  GLN 69  84  84  GLN GLN H . n 
B 2 70  SER 70  85  85  SER SER H . n 
B 2 71  ARG 71  86  86  ARG ARG H . n 
B 2 72  ARG 72  87  87  ARG ARG H . n 
B 2 73  VAL 73  88  88  VAL VAL H . n 
B 2 74  ALA 74  89  89  ALA ALA H . n 
B 2 75  GLN 75  90  90  GLN GLN H . n 
B 2 76  VAL 76  91  91  VAL VAL H . n 
B 2 77  ILE 77  92  92  ILE ILE H . n 
B 2 78  ILE 78  93  93  ILE ILE H . n 
B 2 79  PRO 79  94  94  PRO PRO H . n 
B 2 80  SER 80  95  95  SER SER H . n 
B 2 81  THR 81  96  96  THR THR H . n 
B 2 82  TYR 82  97  97  TYR TYR H . n 
B 2 83  VAL 83  98  98  VAL VAL H . n 
B 2 84  PRO 84  99  99  PRO PRO H . n 
B 2 85  GLY 85  100 100 GLY GLY H . n 
B 2 86  THR 86  101 101 THR THR H . n 
B 2 87  THR 87  102 102 THR THR H . n 
B 2 88  ASN 88  103 103 ASN ASN H . n 
B 2 89  HIS 89  104 104 HIS HIS H . n 
B 2 90  ASP 90  105 105 ASP ASP H . n 
B 2 91  ILE 91  106 106 ILE ILE H . n 
B 2 92  ALA 92  107 107 ALA ALA H . n 
B 2 93  LEU 93  108 108 LEU LEU H . n 
B 2 94  LEU 94  109 109 LEU LEU H . n 
B 2 95  ARG 95  110 110 ARG ARG H . n 
B 2 96  LEU 96  111 111 LEU LEU H . n 
B 2 97  HIS 97  112 112 HIS HIS H . n 
B 2 98  GLN 98  113 113 GLN GLN H . n 
B 2 99  PRO 99  114 114 PRO PRO H . n 
B 2 100 VAL 100 115 115 VAL VAL H . n 
B 2 101 VAL 101 116 116 VAL VAL H . n 
B 2 102 LEU 102 117 117 LEU LEU H . n 
B 2 103 THR 103 118 118 THR THR H . n 
B 2 104 ASP 104 119 119 ASP ASP H . n 
B 2 105 HIS 105 120 120 HIS HIS H . n 
B 2 106 VAL 106 121 121 VAL VAL H . n 
B 2 107 VAL 107 122 122 VAL VAL H . n 
B 2 108 PRO 108 123 123 PRO PRO H . n 
B 2 109 LEU 109 124 124 LEU LEU H . n 
B 2 110 CYS 110 125 125 CYS CYS H . n 
B 2 111 LEU 111 126 126 LEU LEU H . n 
B 2 112 PRO 112 127 127 PRO PRO H . n 
B 2 113 GLU 113 128 128 GLU GLU H . n 
B 2 114 ARG 114 129 129 ARG ARG H . n 
B 2 115 THR 115 130 130 THR THR H . n 
B 2 116 PHE 116 131 131 PHE PHE H . n 
B 2 117 SER 117 132 132 SER SER H . n 
B 2 118 GLU 118 133 133 GLU GLU H . n 
B 2 119 ARG 119 134 134 ARG ARG H . n 
B 2 120 THR 120 135 135 THR THR H . n 
B 2 121 LEU 121 136 136 LEU LEU H . n 
B 2 122 ALA 122 137 137 ALA ALA H . n 
B 2 123 PHE 123 138 138 PHE PHE H . n 
B 2 124 VAL 124 139 139 VAL VAL H . n 
B 2 125 ARG 125 140 140 ARG ARG H . n 
B 2 126 PHE 126 141 141 PHE PHE H . n 
B 2 127 SER 127 142 142 SER SER H . n 
B 2 128 LEU 128 143 143 LEU LEU H . n 
B 2 129 VAL 129 144 144 VAL VAL H . n 
B 2 130 SER 130 145 145 SER SER H . n 
B 2 131 GLY 131 146 146 GLY GLY H . n 
B 2 132 TRP 132 147 147 TRP TRP H . n 
B 2 133 GLY 133 148 148 GLY GLY H . n 
B 2 134 GLN 134 149 149 GLN GLN H . n 
B 2 135 LEU 135 150 150 LEU LEU H . n 
B 2 136 LEU 136 151 151 LEU LEU H . n 
B 2 137 ASP 137 152 152 ASP ASP H . n 
B 2 138 ARG 138 153 153 ARG ARG H . n 
B 2 139 GLY 139 154 154 GLY GLY H . n 
B 2 140 ALA 140 155 155 ALA ALA H . n 
B 2 141 THR 141 156 156 THR THR H . n 
B 2 142 ALA 142 157 157 ALA ALA H . n 
B 2 143 LEU 143 158 158 LEU LEU H . n 
B 2 144 GLU 144 159 159 GLU GLU H . n 
B 2 145 LEU 145 160 160 LEU LEU H . n 
B 2 146 MET 146 161 161 MET MET H . n 
B 2 147 VAL 147 162 162 VAL VAL H . n 
B 2 148 LEU 148 163 163 LEU LEU H . n 
B 2 149 ASN 149 164 164 ASN ASN H . n 
B 2 150 VAL 150 165 165 VAL VAL H . n 
B 2 151 PRO 151 166 166 PRO PRO H . n 
B 2 152 ARG 152 167 167 ARG ARG H . n 
B 2 153 LEU 153 168 168 LEU LEU H . n 
B 2 154 MET 154 169 169 MET MET H . n 
B 2 155 THR 155 170 170 THR THR H . n 
B 2 156 GLN 156 171 171 GLN GLN H . n 
B 2 157 ASP 157 172 172 ASP ASP H . n 
B 2 158 CYS 158 173 173 CYS CYS H . n 
B 2 159 LEU 159 174 174 LEU LEU H . n 
B 2 160 GLN 160 175 175 GLN GLN H . n 
B 2 161 GLN 161 176 176 GLN GLN H . n 
B 2 162 SER 162 177 177 SER SER H . n 
B 2 163 ARG 163 178 178 ARG ARG H . n 
B 2 164 LYS 164 179 179 LYS LYS H . n 
B 2 165 VAL 165 180 180 VAL VAL H . n 
B 2 166 GLY 166 181 181 GLY GLY H . n 
B 2 167 ASP 167 182 182 ASP ASP H . n 
B 2 168 SER 168 183 183 SER SER H . n 
B 2 169 PRO 169 184 184 PRO PRO H . n 
B 2 170 ASN 170 185 185 ASN ASN H . n 
B 2 171 ILE 171 186 186 ILE ILE H . n 
B 2 172 THR 172 187 187 THR THR H . n 
B 2 173 GLU 173 188 188 GLU GLU H . n 
B 2 174 TYR 174 189 189 TYR TYR H . n 
B 2 175 MET 175 190 190 MET MET H . n 
B 2 176 PHE 176 191 191 PHE PHE H . n 
B 2 177 CYS 177 192 192 CYS CYS H . n 
B 2 178 ALA 178 193 193 ALA ALA H . n 
B 2 179 GLY 179 194 194 GLY GLY H . n 
B 2 180 TYR 180 195 195 TYR TYR H . n 
B 2 181 SER 181 196 196 SER SER H . n 
B 2 182 ASP 182 197 197 ASP ASP H . n 
B 2 183 GLY 183 198 198 GLY GLY H . n 
B 2 184 SER 184 199 199 SER SER H . n 
B 2 185 LYS 185 200 200 LYS LYS H . n 
B 2 186 ASP 186 201 201 ASP ASP H . n 
B 2 187 SER 187 202 202 SER SER H . n 
B 2 188 CYS 188 203 203 CYS CYS H . n 
B 2 189 LYS 189 204 204 LYS LYS H . n 
B 2 190 GLY 190 205 205 GLY GLY H . n 
B 2 191 ASP 191 206 206 ASP ASP H . n 
B 2 192 SER 192 207 207 SER SER H . n 
B 2 193 GLY 193 208 208 GLY GLY H . n 
B 2 194 GLY 194 209 209 GLY GLY H . n 
B 2 195 PRO 195 210 210 PRO PRO H . n 
B 2 196 HIS 196 211 211 HIS HIS H . n 
B 2 197 ALA 197 212 212 ALA ALA H . n 
B 2 198 THR 198 213 213 THR THR H . n 
B 2 199 HIS 199 214 214 HIS HIS H . n 
B 2 200 TYR 200 215 215 TYR TYR H . n 
B 2 201 ARG 201 216 216 ARG ARG H . n 
B 2 202 GLY 202 217 217 GLY GLY H . n 
B 2 203 THR 203 218 218 THR THR H . n 
B 2 204 TRP 204 219 219 TRP TRP H . n 
B 2 205 TYR 205 220 220 TYR TYR H . n 
B 2 206 LEU 206 221 221 LEU LEU H . n 
B 2 207 THR 207 222 222 THR THR H . n 
B 2 208 GLY 208 223 223 GLY GLY H . n 
B 2 209 ILE 209 224 224 ILE ILE H . n 
B 2 210 VAL 210 225 225 VAL VAL H . n 
B 2 211 SER 211 226 226 SER SER H . n 
B 2 212 TRP 212 227 227 TRP TRP H . n 
B 2 213 GLY 213 228 228 GLY GLY H . n 
B 2 214 GLN 214 229 229 GLN GLN H . n 
B 2 215 GLY 215 230 230 GLY GLY H . n 
B 2 216 CYS 216 231 231 CYS CYS H . n 
B 2 217 ALA 217 232 232 ALA ALA H . n 
B 2 218 THR 218 233 233 THR THR H . n 
B 2 219 VAL 219 234 234 VAL VAL H . n 
B 2 220 GLY 220 235 235 GLY GLY H . n 
B 2 221 HIS 221 236 236 HIS HIS H . n 
B 2 222 PHE 222 237 237 PHE PHE H . n 
B 2 223 GLY 223 238 238 GLY GLY H . n 
B 2 224 VAL 224 239 239 VAL VAL H . n 
B 2 225 TYR 225 240 240 TYR TYR H . n 
B 2 226 THR 226 241 241 THR THR H . n 
B 2 227 ARG 227 242 242 ARG ARG H . n 
B 2 228 VAL 228 243 243 VAL VAL H . n 
B 2 229 SER 229 244 244 SER SER H . n 
B 2 230 GLN 230 245 245 GLN GLN H . n 
B 2 231 TYR 231 246 246 TYR TYR H . n 
B 2 232 ILE 232 247 247 ILE ILE H . n 
B 2 233 GLU 233 248 248 GLU GLU H . n 
B 2 234 TRP 234 249 249 TRP TRP H . n 
B 2 235 LEU 235 250 250 LEU LEU H . n 
B 2 236 GLN 236 251 251 GLN GLN H . n 
B 2 237 LYS 237 252 252 LYS LYS H . n 
B 2 238 LEU 238 253 253 LEU LEU H . n 
B 2 239 MET 239 254 254 MET MET H . n 
B 2 240 ARG 240 255 255 ARG ARG H . n 
B 2 241 SER 241 256 256 SER SER H . n 
B 2 242 GLU 242 257 257 GLU GLU H . n 
B 2 243 PRO 243 258 258 PRO PRO H . n 
B 2 244 ARG 244 259 259 ARG ARG H . n 
B 2 245 PRO 245 260 260 PRO PRO H . n 
B 2 246 GLY 246 261 261 GLY GLY H . n 
B 2 247 VAL 247 262 262 VAL VAL H . n 
B 2 248 LEU 248 263 263 LEU LEU H . n 
B 2 249 LEU 249 264 264 LEU LEU H . n 
B 2 250 ARG 250 265 265 ARG ARG H . n 
B 2 251 ALA 251 266 266 ALA ALA H . n 
B 2 252 PRO 252 267 267 PRO PRO H . n 
B 2 253 PHE 253 268 268 PHE PHE H . n 
B 2 254 PRO 254 269 269 PRO PRO H . n 
C 3 1   THR 1   6   6   THR THR T . n 
C 3 2   VAL 2   7   7   VAL VAL T . n 
C 3 3   ALA 3   8   8   ALA ALA T . n 
C 3 4   ALA 4   9   9   ALA ALA T . n 
C 3 5   TYR 5   10  10  TYR TYR T . n 
C 3 6   ASN 6   11  11  ASN ASN T . n 
C 3 7   LEU 7   12  12  LEU LEU T . n 
C 3 8   THR 8   13  13  THR THR T . n 
C 3 9   TRP 9   14  14  TRP TRP T . n 
C 3 10  LYS 10  15  15  LYS LYS T . n 
C 3 11  SER 11  16  16  SER SER T . n 
C 3 12  THR 12  17  17  THR THR T . n 
C 3 13  ASN 13  18  18  ASN ASN T . n 
C 3 14  PHE 14  19  19  PHE PHE T . n 
C 3 15  LYS 15  20  20  LYS LYS T . n 
C 3 16  THR 16  21  21  THR THR T . n 
C 3 17  ILE 17  22  22  ILE ILE T . n 
C 3 18  LEU 18  23  23  LEU LEU T . n 
C 3 19  GLU 19  24  24  GLU GLU T . n 
C 3 20  TRP 20  25  25  TRP TRP T . n 
C 3 21  GLU 21  26  26  GLU GLU T . n 
C 3 22  PRO 22  27  27  PRO PRO T . n 
C 3 23  LYS 23  28  28  LYS LYS T . n 
C 3 24  PRO 24  29  29  PRO PRO T . n 
C 3 25  VAL 25  30  30  VAL VAL T . n 
C 3 26  ASN 26  31  31  ASN ASN T . n 
C 3 27  GLN 27  32  32  GLN GLN T . n 
C 3 28  VAL 28  33  33  VAL VAL T . n 
C 3 29  TYR 29  34  34  TYR TYR T . n 
C 3 30  THR 30  35  35  THR THR T . n 
C 3 31  VAL 31  36  36  VAL VAL T . n 
C 3 32  GLN 32  37  37  GLN GLN T . n 
C 3 33  ILE 33  38  38  ILE ILE T . n 
C 3 34  SER 34  39  39  SER SER T . n 
C 3 35  THR 35  40  40  THR THR T . n 
C 3 36  LYS 36  41  41  LYS LYS T . n 
C 3 37  SER 37  42  42  SER SER T . n 
C 3 38  GLY 38  43  43  GLY GLY T . n 
C 3 39  ASP 39  44  44  ASP ASP T . n 
C 3 40  TRP 40  45  45  TRP TRP T . n 
C 3 41  LYS 41  46  46  LYS LYS T . n 
C 3 42  SER 42  47  47  SER SER T . n 
C 3 43  LYS 43  48  48  LYS LYS T . n 
C 3 44  CYS 44  49  49  CYS CYS T . n 
C 3 45  PHE 45  50  50  PHE PHE T . n 
C 3 46  TYR 46  51  51  TYR TYR T . n 
C 3 47  THR 47  52  52  THR THR T . n 
C 3 48  THR 48  53  53  THR THR T . n 
C 3 49  ASP 49  54  54  ASP ASP T . n 
C 3 50  THR 50  55  55  THR THR T . n 
C 3 51  GLU 51  56  56  GLU GLU T . n 
C 3 52  CYS 52  57  57  CYS CYS T . n 
C 3 53  ASP 53  58  58  ASP ASP T . n 
C 3 54  LEU 54  59  59  LEU LEU T . n 
C 3 55  THR 55  60  60  THR THR T . n 
C 3 56  ASP 56  61  61  ASP ASP T . n 
C 3 57  GLU 57  62  62  GLU GLU T . n 
C 3 58  ILE 58  63  63  ILE ILE T . n 
C 3 59  VAL 59  64  64  VAL VAL T . n 
C 3 60  LYS 60  65  65  LYS LYS T . n 
C 3 61  ASP 61  66  66  ASP ASP T . n 
C 3 62  VAL 62  67  67  VAL VAL T . n 
C 3 63  LYS 63  68  68  LYS LYS T . n 
C 3 64  GLN 64  69  69  GLN GLN T . n 
C 3 65  THR 65  70  70  THR THR T . n 
C 3 66  TYR 66  71  71  TYR TYR T . n 
C 3 67  LEU 67  72  72  LEU LEU T . n 
C 3 68  ALA 68  73  73  ALA ALA T . n 
C 3 69  ARG 69  74  74  ARG ARG T . n 
C 3 70  VAL 70  75  75  VAL VAL T . n 
C 3 71  PHE 71  76  76  PHE PHE T . n 
C 3 72  SER 72  77  77  SER SER T . n 
C 3 73  TYR 73  78  78  TYR TYR T . n 
C 3 74  PRO 74  79  79  PRO PRO T . n 
C 3 75  ALA 75  80  80  ALA ALA T . n 
D 4 1   GLU 1   91  91  GLU GLU U . n 
D 4 2   PRO 2   92  92  PRO PRO U . n 
D 4 3   LEU 3   93  93  LEU LEU U . n 
D 4 4   TYR 4   94  94  TYR TYR U . n 
D 4 5   GLU 5   95  95  GLU GLU U . n 
D 4 6   ASN 6   96  96  ASN ASN U . n 
D 4 7   SER 7   97  97  SER SER U . n 
D 4 8   PRO 8   98  98  PRO PRO U . n 
D 4 9   GLU 9   99  99  GLU GLU U . n 
D 4 10  PHE 10  100 100 PHE PHE U . n 
D 4 11  THR 11  101 101 THR THR U . n 
D 4 12  PRO 12  102 102 PRO PRO U . n 
D 4 13  TYR 13  103 103 TYR TYR U . n 
D 4 14  LEU 14  104 104 LEU LEU U . n 
D 4 15  GLU 15  105 105 GLU GLU U . n 
D 4 16  THR 16  106 106 THR THR U . n 
D 4 17  ASN 17  107 107 ASN ASN U . n 
D 4 18  LEU 18  108 108 LEU LEU U . n 
D 4 19  GLY 19  109 109 GLY GLY U . n 
D 4 20  GLN 20  110 110 GLN GLN U . n 
D 4 21  PRO 21  111 111 PRO PRO U . n 
D 4 22  THR 22  112 112 THR THR U . n 
D 4 23  ILE 23  113 113 ILE ILE U . n 
D 4 24  GLN 24  114 114 GLN GLN U . n 
D 4 25  SER 25  115 115 SER SER U . n 
D 4 26  PHE 26  116 116 PHE PHE U . n 
D 4 27  GLU 27  117 117 GLU GLU U . n 
D 4 28  GLN 28  118 118 GLN GLN U . n 
D 4 29  VAL 29  119 119 VAL VAL U . n 
D 4 30  GLY 30  120 120 GLY GLY U . n 
D 4 31  THR 31  121 121 THR THR U . n 
D 4 32  LYS 32  122 122 LYS LYS U . n 
D 4 33  VAL 33  123 123 VAL VAL U . n 
D 4 34  ASN 34  124 124 ASN ASN U . n 
D 4 35  VAL 35  125 125 VAL VAL U . n 
D 4 36  THR 36  126 126 THR THR U . n 
D 4 37  VAL 37  127 127 VAL VAL U . n 
D 4 38  GLU 38  128 128 GLU GLU U . n 
D 4 39  ASP 39  129 129 ASP ASP U . n 
D 4 40  GLU 40  130 130 GLU GLU U . n 
D 4 41  ARG 41  131 131 ARG ARG U . n 
D 4 42  THR 42  132 132 THR THR U . n 
D 4 43  LEU 43  133 133 LEU LEU U . n 
D 4 44  VAL 44  134 134 VAL VAL U . n 
D 4 45  ARG 45  135 135 ARG ARG U . n 
D 4 46  ARG 46  136 136 ARG ARG U . n 
D 4 47  ASN 47  137 137 ASN ASN U . n 
D 4 48  ASN 48  138 138 ASN ASN U . n 
D 4 49  THR 49  139 139 THR THR U . n 
D 4 50  PHE 50  140 140 PHE PHE U . n 
D 4 51  LEU 51  141 141 LEU LEU U . n 
D 4 52  SER 52  142 142 SER SER U . n 
D 4 53  LEU 53  143 143 LEU LEU U . n 
D 4 54  ARG 54  144 144 ARG ARG U . n 
D 4 55  ASP 55  145 145 ASP ASP U . n 
D 4 56  VAL 56  146 146 VAL VAL U . n 
D 4 57  PHE 57  147 147 PHE PHE U . n 
D 4 58  GLY 58  148 148 GLY GLY U . n 
D 4 59  LYS 59  149 149 LYS LYS U . n 
D 4 60  ASP 60  150 150 ASP ASP U . n 
D 4 61  LEU 61  151 151 LEU LEU U . n 
D 4 62  ILE 62  152 152 ILE ILE U . n 
D 4 63  TYR 63  153 153 TYR TYR U . n 
D 4 64  THR 64  154 154 THR THR U . n 
D 4 65  LEU 65  155 155 LEU LEU U . n 
D 4 66  TYR 66  156 156 TYR TYR U . n 
D 4 67  TYR 67  157 157 TYR TYR U . n 
D 4 68  TRP 68  158 158 TRP TRP U . n 
D 4 69  SER 69  163 163 SER SER U . n 
D 4 70  GLY 70  164 164 GLY GLY U . n 
D 4 71  LYS 71  165 165 LYS LYS U . n 
D 4 72  LYS 72  166 166 LYS LYS U . n 
D 4 73  THR 73  167 167 THR THR U . n 
D 4 74  ALA 74  168 168 ALA ALA U . n 
D 4 75  LYS 75  169 169 LYS LYS U . n 
D 4 76  THR 76  170 170 THR THR U . n 
D 4 77  ASN 77  171 171 ASN ASN U . n 
D 4 78  THR 78  172 172 THR THR U . n 
D 4 79  ASN 79  173 173 ASN ASN U . n 
D 4 80  GLU 80  174 174 GLU GLU U . n 
D 4 81  PHE 81  175 175 PHE PHE U . n 
D 4 82  LEU 82  176 176 LEU LEU U . n 
D 4 83  ILE 83  177 177 ILE ILE U . n 
D 4 84  ASP 84  178 178 ASP ASP U . n 
D 4 85  VAL 85  179 179 VAL VAL U . n 
D 4 86  ASP 86  180 180 ASP ASP U . n 
D 4 87  LYS 87  181 181 LYS LYS U . n 
D 4 88  GLY 88  182 182 GLY GLY U . n 
D 4 89  GLU 89  183 183 GLU GLU U . n 
D 4 90  ASN 90  184 184 ASN ASN U . n 
D 4 91  TYR 91  185 185 TYR TYR U . n 
D 4 92  CYS 92  186 186 CYS CYS U . n 
D 4 93  PHE 93  187 187 PHE PHE U . n 
D 4 94  SER 94  188 188 SER SER U . n 
D 4 95  VAL 95  189 189 VAL VAL U . n 
D 4 96  GLN 96  190 190 GLN GLN U . n 
D 4 97  ALA 97  191 191 ALA ALA U . n 
D 4 98  VAL 98  192 192 VAL VAL U . n 
D 4 99  ILE 99  193 193 ILE ILE U . n 
D 4 100 PRO 100 194 194 PRO PRO U . n 
D 4 101 SER 101 195 195 SER SER U . n 
D 4 102 ARG 102 196 196 ARG ARG U . n 
D 4 103 THR 103 197 197 THR THR U . n 
D 4 104 VAL 104 198 198 VAL VAL U . n 
D 4 105 ASN 105 199 199 ASN ASN U . n 
D 4 106 ARG 106 200 200 ARG ARG U . n 
D 4 107 LYS 107 201 201 LYS LYS U . n 
D 4 108 SER 108 202 202 SER SER U . n 
D 4 109 THR 109 203 203 THR THR U . n 
D 4 110 ASP 110 204 204 ASP ASP U . n 
D 4 111 SER 111 205 205 SER SER U . n 
D 4 112 PRO 112 206 206 PRO PRO U . n 
D 4 113 VAL 113 207 207 VAL VAL U . n 
D 4 114 GLU 114 208 208 GLU GLU U . n 
D 4 115 CYS 115 209 209 CYS CYS U . n 
D 4 116 MET 116 210 210 MET MET U . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 5 BGC 1  201 153 BGC BGC L . 
F 6 FUC 1  202 154 FUC FUC L . 
G 7 CA  1  203 155 CA  CA  L . 
H 7 CA  1  204 156 CA  CA  L . 
I 7 CA  1  205 157 CA  CA  L . 
J 7 CA  1  206 158 CA  CA  L . 
K 7 CA  1  207 159 CA  CA  L . 
L 7 CA  1  208 160 CA  CA  L . 
M 7 CA  1  209 161 CA  CA  L . 
N 7 CA  1  210 162 CA  CA  L . 
O 7 CA  1  301 358 CA  CA  H . 
P 8 XGX 1  302 359 XGX BCX H . 
Q 9 HOH 1  301 39  HOH HOH L . 
Q 9 HOH 2  302 40  HOH HOH L . 
Q 9 HOH 3  303 72  HOH HOH L . 
Q 9 HOH 4  304 22  HOH HOH L . 
Q 9 HOH 5  305 129 HOH HOH L . 
Q 9 HOH 6  306 93  HOH HOH L . 
Q 9 HOH 7  307 128 HOH HOH L . 
Q 9 HOH 8  308 41  HOH HOH L . 
Q 9 HOH 9  309 6   HOH HOH L . 
Q 9 HOH 10 310 122 HOH HOH L . 
Q 9 HOH 11 311 29  HOH HOH L . 
Q 9 HOH 12 312 91  HOH HOH L . 
Q 9 HOH 13 313 2   HOH HOH L . 
Q 9 HOH 14 314 37  HOH HOH L . 
Q 9 HOH 15 315 92  HOH HOH L . 
Q 9 HOH 16 316 219 HOH HOH L . 
Q 9 HOH 17 317 75  HOH HOH L . 
Q 9 HOH 18 318 186 HOH HOH L . 
Q 9 HOH 19 319 276 HOH HOH L . 
Q 9 HOH 20 320 143 HOH HOH L . 
Q 9 HOH 21 321 5   HOH HOH L . 
Q 9 HOH 22 322 284 HOH HOH L . 
Q 9 HOH 23 323 267 HOH HOH L . 
Q 9 HOH 24 324 109 HOH HOH L . 
Q 9 HOH 25 325 168 HOH HOH L . 
Q 9 HOH 26 326 298 HOH HOH L . 
Q 9 HOH 27 327 166 HOH HOH L . 
Q 9 HOH 28 328 205 HOH HOH L . 
Q 9 HOH 29 329 221 HOH HOH L . 
Q 9 HOH 30 330 275 HOH HOH L . 
Q 9 HOH 31 331 277 HOH HOH L . 
Q 9 HOH 32 332 279 HOH HOH L . 
R 9 HOH 1  401 132 HOH HOH H . 
R 9 HOH 2  402 99  HOH HOH H . 
R 9 HOH 3  403 180 HOH HOH H . 
R 9 HOH 4  404 18  HOH HOH H . 
R 9 HOH 5  405 3   HOH HOH H . 
R 9 HOH 6  406 49  HOH HOH H . 
R 9 HOH 7  407 133 HOH HOH H . 
R 9 HOH 8  408 19  HOH HOH H . 
R 9 HOH 9  409 10  HOH HOH H . 
R 9 HOH 10 410 252 HOH HOH H . 
R 9 HOH 11 411 1   HOH HOH H . 
R 9 HOH 12 412 24  HOH HOH H . 
R 9 HOH 13 413 43  HOH HOH H . 
R 9 HOH 14 414 66  HOH HOH H . 
R 9 HOH 15 415 79  HOH HOH H . 
R 9 HOH 16 416 25  HOH HOH H . 
R 9 HOH 17 417 4   HOH HOH H . 
R 9 HOH 18 418 153 HOH HOH H . 
R 9 HOH 19 419 107 HOH HOH H . 
R 9 HOH 20 420 171 HOH HOH H . 
R 9 HOH 21 421 98  HOH HOH H . 
R 9 HOH 22 422 7   HOH HOH H . 
R 9 HOH 23 423 15  HOH HOH H . 
R 9 HOH 24 424 65  HOH HOH H . 
R 9 HOH 25 425 73  HOH HOH H . 
R 9 HOH 26 426 55  HOH HOH H . 
R 9 HOH 27 427 16  HOH HOH H . 
R 9 HOH 28 428 52  HOH HOH H . 
R 9 HOH 29 429 33  HOH HOH H . 
R 9 HOH 30 430 232 HOH HOH H . 
R 9 HOH 31 431 282 HOH HOH H . 
R 9 HOH 32 432 21  HOH HOH H . 
R 9 HOH 33 433 215 HOH HOH H . 
R 9 HOH 34 434 163 HOH HOH H . 
R 9 HOH 35 435 103 HOH HOH H . 
R 9 HOH 36 436 30  HOH HOH H . 
R 9 HOH 37 437 78  HOH HOH H . 
R 9 HOH 38 438 88  HOH HOH H . 
R 9 HOH 39 439 273 HOH HOH H . 
R 9 HOH 40 440 85  HOH HOH H . 
R 9 HOH 41 441 60  HOH HOH H . 
R 9 HOH 42 442 288 HOH HOH H . 
R 9 HOH 43 443 31  HOH HOH H . 
R 9 HOH 44 444 291 HOH HOH H . 
R 9 HOH 45 445 283 HOH HOH H . 
R 9 HOH 46 446 183 HOH HOH H . 
R 9 HOH 47 447 231 HOH HOH H . 
R 9 HOH 48 448 289 HOH HOH H . 
R 9 HOH 49 449 290 HOH HOH H . 
R 9 HOH 50 450 59  HOH HOH H . 
R 9 HOH 51 451 296 HOH HOH H . 
S 9 HOH 1  101 124 HOH HOH T . 
S 9 HOH 2  102 64  HOH HOH T . 
S 9 HOH 3  103 96  HOH HOH T . 
S 9 HOH 4  104 12  HOH HOH T . 
S 9 HOH 5  105 95  HOH HOH T . 
S 9 HOH 6  106 213 HOH HOH T . 
S 9 HOH 7  107 23  HOH HOH T . 
S 9 HOH 8  108 54  HOH HOH T . 
S 9 HOH 9  109 142 HOH HOH T . 
S 9 HOH 10 110 130 HOH HOH T . 
S 9 HOH 11 111 81  HOH HOH T . 
S 9 HOH 12 112 77  HOH HOH T . 
S 9 HOH 13 113 45  HOH HOH T . 
S 9 HOH 14 114 11  HOH HOH T . 
S 9 HOH 15 115 272 HOH HOH T . 
S 9 HOH 16 116 274 HOH HOH T . 
S 9 HOH 17 117 299 HOH HOH T . 
T 9 HOH 1  301 61  HOH HOH U . 
T 9 HOH 2  302 144 HOH HOH U . 
T 9 HOH 3  303 47  HOH HOH U . 
T 9 HOH 4  304 216 HOH HOH U . 
T 9 HOH 5  305 110 HOH HOH U . 
T 9 HOH 6  306 82  HOH HOH U . 
T 9 HOH 7  307 164 HOH HOH U . 
T 9 HOH 8  308 97  HOH HOH U . 
T 9 HOH 9  309 34  HOH HOH U . 
T 9 HOH 10 310 35  HOH HOH U . 
T 9 HOH 11 311 84  HOH HOH U . 
T 9 HOH 12 312 118 HOH HOH U . 
T 9 HOH 13 313 8   HOH HOH U . 
T 9 HOH 14 314 292 HOH HOH U . 
T 9 HOH 15 315 70  HOH HOH U . 
T 9 HOH 16 316 259 HOH HOH U . 
T 9 HOH 17 317 185 HOH HOH U . 
T 9 HOH 18 318 286 HOH HOH U . 
T 9 HOH 19 319 251 HOH HOH U . 
T 9 HOH 20 320 139 HOH HOH U . 
T 9 HOH 21 321 177 HOH HOH U . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC       ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrystalClear ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SCALEPACK    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? CNX          ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8UUD 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     70.494 
_cell.length_a_esd                 ? 
_cell.length_b                     82.870 
_cell.length_b_esd                 ? 
_cell.length_c                     126.555 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8UUD 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8UUD 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.66 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          53.74 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '14% (w/v)PEG 4K, 0.1M MgCl2, 0.1M ADA buffer, pH 6.5, VAPOR DIFFUSION,' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     98 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     'IMAGE PLATE' 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU RAXIS' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2000-01-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    1.5418 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-D' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8UUD 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.400 
_reflns.d_resolution_low                               47.13 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25452 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     3 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           90 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          1.50 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.10 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.40 
_reflns_shell.d_res_low                                     2.40 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1000 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  3.0 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.09 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            0.01 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -0.10 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               36.433 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.931 
_refine.correlation_coeff_Fo_to_Fc_free          0.875 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8UUD 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.40 
_refine.ls_d_res_low                             47.09 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25452 
_refine.ls_number_reflns_R_free                  1290 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    90.01 
_refine.ls_percent_reflns_R_free                 4.8 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20697 
_refine.ls_R_factor_R_free                       0.26496 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20406 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.461 
_refine.pdbx_overall_ESU_R_Free                  0.292 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             10.301 
_refine.overall_SU_ML                            0.231 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.40 
_refine_hist.d_res_low                        47.09 
_refine_hist.number_atoms_solvent             121 
_refine_hist.number_atoms_total               4848 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4727 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  4875  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.016  4417  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.583  1.671  6514  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.530  1.585  10194 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 8.220  5.000  555   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 26.937 9.286  42    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 16.481 10.000 770   ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.068  0.200  732   ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  5521  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1087  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 4.407  3.434  2339  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 4.403  3.434  2339  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 5.830  5.971  2839  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.830  5.972  2840  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.268  4.113  2536  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.267  4.113  2537  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 7.575  7.081  3676  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 12.000 35.31  5148  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 12.006 35.31  5140  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.400 
_refine_ls_shell.d_res_low                        2.462 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             73 
_refine_ls_shell.number_reflns_R_work             1488 
_refine_ls_shell.percent_reflns_obs               72.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.324 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.351 
# 
_struct.entry_id                     8UUD 
_struct.title                        'BCX2627 complexed with human FVIIa and soluble Tissue Factor.' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8UUD 
_struct_keywords.text            'Factor VIIA & soluble Tissue factor, BLOOD CLOTTING' 
_struct_keywords.pdbx_keywords   'BLOOD CLOTTING' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
G N N 7 ? 
H N N 7 ? 
I N N 7 ? 
J N N 7 ? 
K N N 7 ? 
L N N 7 ? 
M N N 7 ? 
N N N 7 ? 
O N N 7 ? 
P N N 8 ? 
Q N N 9 ? 
R N N 9 ? 
S N N 9 ? 
T N N 9 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP FA7_HUMAN P08709 ? 1 
;ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRN
CETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
;
61  
2 UNP FA7_HUMAN P08709 ? 2 
;IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQ
QSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMR
SEPRPGVLLRAPFP
;
213 
3 UNP TF_HUMAN  P13726 ? 3 TVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPA 38  
4 UNP TF_HUMAN  P13726 ? 4 
;EPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKT
NTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECM
;
123 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8UUD L 1 ? 142 ? P08709 61  ? 202 ? 1  142 
2 2 8UUD H 1 ? 254 ? P08709 213 ? 466 ? 16 269 
3 3 8UUD T 1 ? 75  ? P13726 38  ? 112 ? 6  80  
4 4 8UUD U 1 ? 116 ? P13726 123 ? 242 ? 91 210 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
4 8UUD ? U ? ? UNP P13726 LYS 191 deletion ? 1 
4 8UUD ? U ? ? UNP P13726 SER 192 deletion ? 2 
4 8UUD ? U ? ? UNP P13726 SER 193 deletion ? 3 
4 8UUD ? U ? ? UNP P13726 SER 194 deletion ? 4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 9410  ? 
1 MORE         -118  ? 
1 'SSA (A^2)'  27170 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 5   ? ARG A 9   ? LEU L 5   ARG L 9   5 ? 5  
HELX_P HELX_P2  AA2 LEU A 13  ? LYS A 18  ? LEU L 13  LYS L 18  1 ? 6  
HELX_P HELX_P3  AA3 ALA A 27  ? LYS A 32  ? ALA L 27  LYS L 32  1 ? 6  
HELX_P HELX_P4  AA4 ALA A 34  ? SER A 45  ? ALA L 34  SER L 45  1 ? 12 
HELX_P HELX_P5  AA5 ASP A 48  ? SER A 53  ? ASP L 48  SER L 53  5 ? 6  
HELX_P HELX_P6  AA6 ASP A 86  ? LEU A 89  ? ASP L 86  LEU L 89  5 ? 4  
HELX_P HELX_P7  AA7 ASN A 93  ? CYS A 98  ? ASN L 93  CYS L 98  5 ? 6  
HELX_P HELX_P8  AA8 ILE A 138 ? GLU A 142 ? ILE L 138 GLU L 142 5 ? 5  
HELX_P HELX_P9  AA9 ALA B 39  ? ASP B 44  ? ALA H 54  ASP H 59  5 ? 6  
HELX_P HELX_P10 AB1 GLU B 113 ? THR B 120 ? GLU H 128 THR H 135 1 ? 8  
HELX_P HELX_P11 AB2 LEU B 121 ? VAL B 124 ? LEU H 136 VAL H 139 5 ? 4  
HELX_P HELX_P12 AB3 MET B 154 ? GLN B 160 ? MET H 169 GLN H 175 1 ? 7  
HELX_P HELX_P13 AB4 TYR B 231 ? ARG B 240 ? TYR H 246 ARG H 255 1 ? 10 
HELX_P HELX_P14 AB5 LEU C 54  ? VAL C 59  ? LEU T 59  VAL T 64  1 ? 6  
HELX_P HELX_P15 AB6 THR D 11  ? THR D 16  ? THR U 101 THR U 106 1 ? 6  
HELX_P HELX_P16 AB7 LEU D 53  ? GLY D 58  ? LEU U 143 GLY U 148 1 ? 6  
HELX_P HELX_P17 AB8 LYS D 59  ? LEU D 61  ? LYS U 149 LEU U 151 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 17  SG   ? ? ? 1_555 A CYS 22  SG ? ? L CYS 17  L CYS 22  1_555 ? ? ? ? ? ? ? 2.059 ? ?               
disulf2  disulf ?    ? A CYS 50  SG   ? ? ? 1_555 A CYS 61  SG ? ? L CYS 50  L CYS 61  1_555 ? ? ? ? ? ? ? 2.049 ? ?               
disulf3  disulf ?    ? A CYS 55  SG   ? ? ? 1_555 A CYS 70  SG ? ? L CYS 55  L CYS 70  1_555 ? ? ? ? ? ? ? 2.020 ? ?               
disulf4  disulf ?    ? A CYS 72  SG   ? ? ? 1_555 A CYS 81  SG ? ? L CYS 72  L CYS 81  1_555 ? ? ? ? ? ? ? 2.017 ? ?               
disulf5  disulf ?    ? A CYS 91  SG   ? ? ? 1_555 A CYS 102 SG ? ? L CYS 91  L CYS 102 1_555 ? ? ? ? ? ? ? 1.976 ? ?               
disulf6  disulf ?    ? A CYS 98  SG   ? ? ? 1_555 A CYS 112 SG ? ? L CYS 98  L CYS 112 1_555 ? ? ? ? ? ? ? 2.021 ? ?               
disulf7  disulf ?    ? A CYS 114 SG   ? ? ? 1_555 A CYS 127 SG ? ? L CYS 114 L CYS 127 1_555 ? ? ? ? ? ? ? 1.994 ? ?               
disulf8  disulf ?    ? A CYS 135 SG   ? ? ? 1_555 B CYS 110 SG ? ? L CYS 135 H CYS 125 1_555 ? ? ? ? ? ? ? 2.065 ? ?               
disulf9  disulf ?    ? B CYS 7   SG   ? ? ? 1_555 B CYS 12  SG ? ? H CYS 22  H CYS 27  1_555 ? ? ? ? ? ? ? 1.994 ? ?               
disulf10 disulf ?    ? B CYS 26  SG   ? ? ? 1_555 B CYS 42  SG ? ? H CYS 41  H CYS 57  1_555 ? ? ? ? ? ? ? 2.023 ? ?               
disulf11 disulf ?    ? B CYS 158 SG   ? ? ? 1_555 B CYS 177 SG ? ? H CYS 173 H CYS 192 1_555 ? ? ? ? ? ? ? 2.055 ? ?               
disulf12 disulf ?    ? B CYS 188 SG   ? ? ? 1_555 B CYS 216 SG ? ? H CYS 203 H CYS 231 1_555 ? ? ? ? ? ? ? 2.021 ? ?               
disulf13 disulf ?    ? C CYS 44  SG   ? ? ? 1_555 C CYS 52  SG ? ? T CYS 49  T CYS 57  1_555 ? ? ? ? ? ? ? 2.013 ? ?               
disulf14 disulf ?    ? D CYS 92  SG   ? ? ? 1_555 D CYS 115 SG ? ? U CYS 186 U CYS 209 1_555 ? ? ? ? ? ? ? 2.013 ? ?               
covale1  covale both ? A LEU 5   C    ? ? ? 1_555 A CGU 6   N  ? ? L LEU 5   L CGU 6   1_555 ? ? ? ? ? ? ? 1.424 ? ?               
covale2  covale both ? A CGU 6   C    ? ? ? 1_555 A CGU 7   N  ? ? L CGU 6   L CGU 7   1_555 ? ? ? ? ? ? ? 1.417 ? ?               
covale3  covale both ? A CGU 7   C    ? ? ? 1_555 A LEU 8   N  ? ? L CGU 7   L LEU 8   1_555 ? ? ? ? ? ? ? 1.441 ? ?               
covale4  covale both ? A LEU 13  C    ? ? ? 1_555 A CGU 14  N  ? ? L LEU 13  L CGU 14  1_555 ? ? ? ? ? ? ? 1.444 ? ?               
covale5  covale both ? A CGU 14  C    ? ? ? 1_555 A ARG 15  N  ? ? L CGU 14  L ARG 15  1_555 ? ? ? ? ? ? ? 1.446 ? ?               
covale6  covale both ? A ARG 15  C    ? ? ? 1_555 A CGU 16  N  ? ? L ARG 15  L CGU 16  1_555 ? ? ? ? ? ? ? 1.459 ? ?               
covale7  covale both ? A CGU 16  C    ? ? ? 1_555 A CYS 17  N  ? ? L CGU 16  L CYS 17  1_555 ? ? ? ? ? ? ? 1.469 ? ?               
covale8  covale both ? A LYS 18  C    ? ? ? 1_555 A CGU 19  N  ? ? L LYS 18  L CGU 19  1_555 ? ? ? ? ? ? ? 1.448 ? ?               
covale9  covale both ? A CGU 19  C    ? ? ? 1_555 A CGU 20  N  ? ? L CGU 19  L CGU 20  1_555 ? ? ? ? ? ? ? 1.455 ? ?               
covale10 covale both ? A CGU 20  C    ? ? ? 1_555 A GLN 21  N  ? ? L CGU 20  L GLN 21  1_555 ? ? ? ? ? ? ? 1.458 ? ?               
covale11 covale both ? A PHE 24  C    ? ? ? 1_555 A CGU 25  N  ? ? L PHE 24  L CGU 25  1_555 ? ? ? ? ? ? ? 1.444 ? ?               
covale12 covale both ? A CGU 25  C    ? ? ? 1_555 A CGU 26  N  ? ? L CGU 25  L CGU 26  1_555 ? ? ? ? ? ? ? 1.479 ? ?               
covale13 covale both ? A CGU 26  C    ? ? ? 1_555 A ALA 27  N  ? ? L CGU 26  L ALA 27  1_555 ? ? ? ? ? ? ? 1.435 ? ?               
covale14 covale both ? A ARG 28  C    ? ? ? 1_555 A CGU 29  N  ? ? L ARG 28  L CGU 29  1_555 ? ? ? ? ? ? ? 1.447 ? ?               
covale15 covale both ? A CGU 29  C    ? ? ? 1_555 A ILE 30  N  ? ? L CGU 29  L ILE 30  1_555 ? ? ? ? ? ? ? 1.450 ? ?               
covale16 covale both ? A ALA 34  C    ? ? ? 1_555 A CGU 35  N  ? ? L ALA 34  L CGU 35  1_555 ? ? ? ? ? ? ? 1.477 ? ?               
covale17 covale both ? A CGU 35  C    ? ? ? 1_555 A ARG 36  N  ? ? L CGU 35  L ARG 36  1_555 ? ? ? ? ? ? ? 1.453 ? ?               
covale18 covale one  ? A SER 52  OG   ? ? ? 1_555 E BGC .   C1 ? ? L SER 52  L BGC 201 1_555 ? ? ? ? ? ? ? 1.444 ? O-Glycosylation 
covale19 covale one  ? A SER 60  OG   ? ? ? 1_555 F FUC .   C1 ? ? L SER 60  L FUC 202 1_555 ? ? ? ? ? ? ? 1.441 ? O-Glycosylation 
metalc1  metalc ?    ? A ALA 1   O    ? ? ? 1_555 J CA  .   CA ? ? L ALA 1   L CA  206 1_555 ? ? ? ? ? ? ? 2.452 ? ?               
metalc2  metalc ?    ? A ALA 1   O    ? ? ? 1_555 K CA  .   CA ? ? L ALA 1   L CA  207 1_555 ? ? ? ? ? ? ? 2.440 ? ?               
metalc3  metalc ?    ? A ASN 2   OD1  ? ? ? 1_555 J CA  .   CA ? ? L ASN 2   L CA  206 1_555 ? ? ? ? ? ? ? 2.422 ? ?               
metalc4  metalc ?    ? A CGU 6   OE11 ? ? ? 1_555 J CA  .   CA ? ? L CGU 6   L CA  206 1_555 ? ? ? ? ? ? ? 2.450 ? ?               
metalc5  metalc ?    ? A CGU 6   OE11 ? ? ? 1_555 K CA  .   CA ? ? L CGU 6   L CA  207 1_555 ? ? ? ? ? ? ? 2.426 ? ?               
metalc6  metalc ?    ? A CGU 6   OE21 ? ? ? 1_555 K CA  .   CA ? ? L CGU 6   L CA  207 1_555 ? ? ? ? ? ? ? 2.440 ? ?               
metalc7  metalc ?    ? A CGU 7   OE12 ? ? ? 1_555 H CA  .   CA ? ? L CGU 7   L CA  204 1_555 ? ? ? ? ? ? ? 2.444 ? ?               
metalc8  metalc ?    ? A CGU 7   OE21 ? ? ? 1_555 H CA  .   CA ? ? L CGU 7   L CA  204 1_555 ? ? ? ? ? ? ? 2.479 ? ?               
metalc9  metalc ?    ? A CGU 7   OE11 ? ? ? 1_555 I CA  .   CA ? ? L CGU 7   L CA  205 1_555 ? ? ? ? ? ? ? 2.463 ? ?               
metalc10 metalc ?    ? A CGU 7   OE12 ? ? ? 1_555 I CA  .   CA ? ? L CGU 7   L CA  205 1_555 ? ? ? ? ? ? ? 2.443 ? ?               
metalc11 metalc ?    ? A CGU 7   OE11 ? ? ? 1_555 J CA  .   CA ? ? L CGU 7   L CA  206 1_555 ? ? ? ? ? ? ? 2.448 ? ?               
metalc12 metalc ?    ? A CGU 14  OE11 ? ? ? 1_555 L CA  .   CA ? ? L CGU 14  L CA  208 1_555 ? ? ? ? ? ? ? 2.407 ? ?               
metalc13 metalc ?    ? A CGU 14  OE21 ? ? ? 1_555 L CA  .   CA ? ? L CGU 14  L CA  208 1_555 ? ? ? ? ? ? ? 2.414 ? ?               
metalc14 metalc ?    ? A CGU 16  OE21 ? ? ? 1_555 I CA  .   CA ? ? L CGU 16  L CA  205 1_555 ? ? ? ? ? ? ? 3.057 ? ?               
metalc15 metalc ?    ? A CGU 16  OE22 ? ? ? 1_555 I CA  .   CA ? ? L CGU 16  L CA  205 1_555 ? ? ? ? ? ? ? 2.422 ? ?               
metalc16 metalc ?    ? A CGU 16  OE11 ? ? ? 1_555 J CA  .   CA ? ? L CGU 16  L CA  206 1_555 ? ? ? ? ? ? ? 2.413 ? ?               
metalc17 metalc ?    ? A CGU 16  OE22 ? ? ? 1_555 J CA  .   CA ? ? L CGU 16  L CA  206 1_555 ? ? ? ? ? ? ? 2.409 ? ?               
metalc18 metalc ?    ? A CGU 16  OE11 ? ? ? 1_555 K CA  .   CA ? ? L CGU 16  L CA  207 1_555 ? ? ? ? ? ? ? 2.433 ? ?               
metalc19 metalc ?    ? A CGU 16  OE12 ? ? ? 1_555 K CA  .   CA ? ? L CGU 16  L CA  207 1_555 ? ? ? ? ? ? ? 2.468 ? ?               
metalc20 metalc ?    ? A CGU 19  OE12 ? ? ? 1_555 L CA  .   CA ? ? L CGU 19  L CA  208 1_555 ? ? ? ? ? ? ? 2.422 ? ?               
metalc21 metalc ?    ? A CGU 19  OE21 ? ? ? 1_555 L CA  .   CA ? ? L CGU 19  L CA  208 1_555 ? ? ? ? ? ? ? 2.421 ? ?               
metalc22 metalc ?    ? A CGU 20  OE21 ? ? ? 1_555 K CA  .   CA ? ? L CGU 20  L CA  207 1_555 ? ? ? ? ? ? ? 2.425 ? ?               
metalc23 metalc ?    ? A CGU 20  OE22 ? ? ? 1_555 K CA  .   CA ? ? L CGU 20  L CA  207 1_555 ? ? ? ? ? ? ? 2.452 ? ?               
metalc24 metalc ?    ? A CGU 20  OE12 ? ? ? 1_555 M CA  .   CA ? ? L CGU 20  L CA  209 1_555 ? ? ? ? ? ? ? 2.429 ? ?               
metalc25 metalc ?    ? A CGU 20  OE22 ? ? ? 1_555 M CA  .   CA ? ? L CGU 20  L CA  209 1_555 ? ? ? ? ? ? ? 2.433 ? ?               
metalc26 metalc ?    ? A CGU 25  OE12 ? ? ? 1_555 N CA  .   CA ? ? L CGU 25  L CA  210 1_555 ? ? ? ? ? ? ? 2.455 ? ?               
metalc27 metalc ?    ? A CGU 25  OE22 ? ? ? 1_555 N CA  .   CA ? ? L CGU 25  L CA  210 1_555 ? ? ? ? ? ? ? 2.465 ? ?               
metalc28 metalc ?    ? A CGU 26  OE11 ? ? ? 1_555 H CA  .   CA ? ? L CGU 26  L CA  204 1_555 ? ? ? ? ? ? ? 2.451 ? ?               
metalc29 metalc ?    ? A CGU 26  OE12 ? ? ? 1_555 H CA  .   CA ? ? L CGU 26  L CA  204 1_555 ? ? ? ? ? ? ? 2.988 ? ?               
metalc30 metalc ?    ? A CGU 26  OE11 ? ? ? 1_555 I CA  .   CA ? ? L CGU 26  L CA  205 1_555 ? ? ? ? ? ? ? 3.100 ? ?               
metalc31 metalc ?    ? A CGU 26  OE12 ? ? ? 1_555 I CA  .   CA ? ? L CGU 26  L CA  205 1_555 ? ? ? ? ? ? ? 2.419 ? ?               
metalc32 metalc ?    ? A CGU 26  OE12 ? ? ? 1_555 J CA  .   CA ? ? L CGU 26  L CA  206 1_555 ? ? ? ? ? ? ? 2.463 ? ?               
metalc33 metalc ?    ? A CGU 26  OE22 ? ? ? 1_555 J CA  .   CA ? ? L CGU 26  L CA  206 1_555 ? ? ? ? ? ? ? 2.430 ? ?               
metalc34 metalc ?    ? A CGU 29  OE21 ? ? ? 1_555 H CA  .   CA ? ? L CGU 29  L CA  204 1_555 ? ? ? ? ? ? ? 2.451 ? ?               
metalc35 metalc ?    ? A CGU 29  OE22 ? ? ? 1_555 H CA  .   CA ? ? L CGU 29  L CA  204 1_555 ? ? ? ? ? ? ? 2.446 ? ?               
metalc36 metalc ?    ? A CGU 29  OE22 ? ? ? 1_555 I CA  .   CA ? ? L CGU 29  L CA  205 1_555 ? ? ? ? ? ? ? 2.461 ? ?               
metalc37 metalc ?    ? A CGU 29  OE11 ? ? ? 1_555 N CA  .   CA ? ? L CGU 29  L CA  210 1_555 ? ? ? ? ? ? ? 2.423 ? ?               
metalc38 metalc ?    ? A CGU 29  OE12 ? ? ? 1_555 N CA  .   CA ? ? L CGU 29  L CA  210 1_555 ? ? ? ? ? ? ? 2.917 ? ?               
metalc39 metalc ?    ? A CGU 29  OE21 ? ? ? 1_555 N CA  .   CA ? ? L CGU 29  L CA  210 1_555 ? ? ? ? ? ? ? 2.446 ? ?               
metalc40 metalc ?    ? A ASP 46  OD2  ? ? ? 1_555 G CA  .   CA ? ? L ASP 46  L CA  203 1_555 ? ? ? ? ? ? ? 2.408 ? ?               
metalc41 metalc ?    ? A GLY 47  O    ? ? ? 1_555 G CA  .   CA ? ? L GLY 47  L CA  203 1_555 ? ? ? ? ? ? ? 2.448 ? ?               
metalc42 metalc ?    ? A GLN 49  OE1  ? ? ? 1_555 G CA  .   CA ? ? L GLN 49  L CA  203 1_555 ? ? ? ? ? ? ? 2.444 ? ?               
metalc43 metalc ?    ? A ASP 63  OD1  ? ? ? 1_555 G CA  .   CA ? ? L ASP 63  L CA  203 1_555 ? ? ? ? ? ? ? 2.451 ? ?               
metalc44 metalc ?    ? A ASP 63  OD2  ? ? ? 1_555 G CA  .   CA ? ? L ASP 63  L CA  203 1_555 ? ? ? ? ? ? ? 2.444 ? ?               
metalc45 metalc ?    ? A GLN 64  O    ? ? ? 1_555 G CA  .   CA ? ? L GLN 64  L CA  203 1_555 ? ? ? ? ? ? ? 2.408 ? ?               
metalc46 metalc ?    ? B GLU 58  OE1  ? ? ? 1_555 O CA  .   CA ? ? H GLU 73  H CA  301 1_555 ? ? ? ? ? ? ? 3.146 ? ?               
metalc47 metalc ?    ? B GLU 58  OE2  ? ? ? 1_555 O CA  .   CA ? ? H GLU 73  H CA  301 1_555 ? ? ? ? ? ? ? 2.225 ? ?               
metalc48 metalc ?    ? B ASP 60  O    ? ? ? 1_555 O CA  .   CA ? ? H ASP 75  H CA  301 1_555 ? ? ? ? ? ? ? 2.204 ? ?               
metalc49 metalc ?    ? B GLU 63  O    ? ? ? 1_555 O CA  .   CA ? ? H GLU 78  H CA  301 1_555 ? ? ? ? ? ? ? 2.230 ? ?               
metalc50 metalc ?    ? B GLU 68  OE1  ? ? ? 1_555 O CA  .   CA ? ? H GLU 83  H CA  301 1_555 ? ? ? ? ? ? ? 3.142 ? ?               
metalc51 metalc ?    ? B GLU 68  OE2  ? ? ? 1_555 O CA  .   CA ? ? H GLU 83  H CA  301 1_555 ? ? ? ? ? ? ? 2.415 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1   O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OD1  ? A ASN 2  ? L ASN 2  ? 1_555 82.7  ? 
2   O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 6  ? L CGU 6  ? 1_555 61.4  ? 
3   OD1  ? A ASN 2  ? L ASN 2  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 6  ? L CGU 6  ? 1_555 124.8 ? 
4   O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 7  ? L CGU 7  ? 1_555 137.8 ? 
5   OD1  ? A ASN 2  ? L ASN 2  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 7  ? L CGU 7  ? 1_555 118.4 ? 
6   OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 7  ? L CGU 7  ? 1_555 77.1  ? 
7   O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 67.7  ? 
8   OD1  ? A ASN 2  ? L ASN 2  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 135.2 ? 
9   OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 69.3  ? 
10  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 105.9 ? 
11  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 132.0 ? 
12  OD1  ? A ASN 2  ? L ASN 2  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 130.2 ? 
13  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 104.6 ? 
14  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 63.5  ? 
15  OE11 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 64.5  ? 
16  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 147.3 ? 
17  OD1  ? A ASN 2  ? L ASN 2  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 64.7  ? 
18  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 140.3 ? 
19  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 66.7  ? 
20  OE11 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 135.3 ? 
21  OE22 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 73.9  ? 
22  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 97.8  ? 
23  OD1  ? A ASN 2  ? L ASN 2  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 32.7  ? 
24  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 155.1 ? 
25  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 119.8 ? 
26  OE11 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 117.5 ? 
27  OE22 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 99.6  ? 
28  OE12 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? J CA . ? L CA 206 ? 1_555 OE22 ? A CGU 26 ? L CGU 26 ? 1_555 53.2  ? 
29  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE11 ? A CGU 6  ? L CGU 6  ? 1_555 61.9  ? 
30  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 6  ? L CGU 6  ? 1_555 85.0  ? 
31  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 6  ? L CGU 6  ? 1_555 75.5  ? 
32  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 67.6  ? 
33  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 69.3  ? 
34  OE21 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE11 ? A CGU 16 ? L CGU 16 ? 1_555 142.6 ? 
35  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE12 ? A CGU 16 ? L CGU 16 ? 1_555 116.5 ? 
36  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE12 ? A CGU 16 ? L CGU 16 ? 1_555 76.6  ? 
37  OE21 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE12 ? A CGU 16 ? L CGU 16 ? 1_555 129.6 ? 
38  OE11 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE12 ? A CGU 16 ? L CGU 16 ? 1_555 53.3  ? 
39  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 20 ? L CGU 20 ? 1_555 67.0  ? 
40  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 20 ? L CGU 20 ? 1_555 128.8 ? 
41  OE21 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 20 ? L CGU 20 ? 1_555 100.7 ? 
42  OE11 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 20 ? L CGU 20 ? 1_555 91.7  ? 
43  OE12 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE21 ? A CGU 20 ? L CGU 20 ? 1_555 129.4 ? 
44  O    ? A ALA 1  ? L ALA 1  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 120.8 ? 
45  OE11 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 177.2 ? 
46  OE21 ? A CGU 6  ? L CGU 6  ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 103.7 ? 
47  OE11 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 112.0 ? 
48  OE12 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 102.2 ? 
49  OE21 ? A CGU 20 ? L CGU 20 ? 1_555 CA ? K CA . ? L CA 207 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 53.9  ? 
50  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE21 ? A CGU 7  ? L CGU 7  ? 1_555 56.8  ? 
51  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE11 ? A CGU 26 ? L CGU 26 ? 1_555 108.8 ? 
52  OE21 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE11 ? A CGU 26 ? L CGU 26 ? 1_555 121.1 ? 
53  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 66.6  ? 
54  OE21 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 79.5  ? 
55  OE11 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 47.7  ? 
56  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 139.1 ? 
57  OE21 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 157.2 ? 
58  OE11 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 73.7  ? 
59  OE12 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 119.9 ? 
60  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 89.0  ? 
61  OE21 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 145.6 ? 
62  OE11 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 63.4  ? 
63  OE12 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 84.2  ? 
64  OE21 ? A CGU 29 ? L CGU 29 ? 1_555 CA ? H CA . ? L CA 204 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 54.6  ? 
65  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE12 ? A CGU 7  ? L CGU 7  ? 1_555 53.5  ? 
66  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE21 ? A CGU 16 ? L CGU 16 ? 1_555 100.3 ? 
67  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE21 ? A CGU 16 ? L CGU 16 ? 1_555 148.4 ? 
68  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 63.1  ? 
69  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 116.3 ? 
70  OE21 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 16 ? L CGU 16 ? 1_555 45.0  ? 
71  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE11 ? A CGU 26 ? L CGU 26 ? 1_555 111.0 ? 
72  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE11 ? A CGU 26 ? L CGU 26 ? 1_555 91.0  ? 
73  OE21 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE11 ? A CGU 26 ? L CGU 26 ? 1_555 117.3 ? 
74  OE22 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE11 ? A CGU 26 ? L CGU 26 ? 1_555 106.7 ? 
75  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 67.2  ? 
76  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 76.7  ? 
77  OE21 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 112.0 ? 
78  OE22 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 74.5  ? 
79  OE11 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE12 ? A CGU 26 ? L CGU 26 ? 1_555 46.2  ? 
80  OE11 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 140.9 ? 
81  OE12 ? A CGU 7  ? L CGU 7  ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 88.7  ? 
82  OE21 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 118.8 ? 
83  OE22 ? A CGU 16 ? L CGU 16 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 150.0 ? 
84  OE11 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 53.6  ? 
85  OE12 ? A CGU 26 ? L CGU 26 ? 1_555 CA ? I CA . ? L CA 205 ? 1_555 OE22 ? A CGU 29 ? L CGU 29 ? 1_555 97.4  ? 
86  OE11 ? A CGU 14 ? L CGU 14 ? 1_555 CA ? L CA . ? L CA 208 ? 1_555 OE21 ? A CGU 14 ? L CGU 14 ? 1_555 76.7  ? 
87  OE11 ? A CGU 14 ? L CGU 14 ? 1_555 CA ? L CA . ? L CA 208 ? 1_555 OE12 ? A CGU 19 ? L CGU 19 ? 1_555 125.2 ? 
88  OE21 ? A CGU 14 ? L CGU 14 ? 1_555 CA ? L CA . ? L CA 208 ? 1_555 OE12 ? A CGU 19 ? L CGU 19 ? 1_555 151.2 ? 
89  OE11 ? A CGU 14 ? L CGU 14 ? 1_555 CA ? L CA . ? L CA 208 ? 1_555 OE21 ? A CGU 19 ? L CGU 19 ? 1_555 62.6  ? 
90  OE21 ? A CGU 14 ? L CGU 14 ? 1_555 CA ? L CA . ? L CA 208 ? 1_555 OE21 ? A CGU 19 ? L CGU 19 ? 1_555 118.5 ? 
91  OE12 ? A CGU 19 ? L CGU 19 ? 1_555 CA ? L CA . ? L CA 208 ? 1_555 OE21 ? A CGU 19 ? L CGU 19 ? 1_555 89.8  ? 
92  OE12 ? A CGU 20 ? L CGU 20 ? 1_555 CA ? M CA . ? L CA 209 ? 1_555 OE22 ? A CGU 20 ? L CGU 20 ? 1_555 92.7  ? 
93  OE12 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE22 ? A CGU 25 ? L CGU 25 ? 1_555 52.3  ? 
94  OE12 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE11 ? A CGU 29 ? L CGU 29 ? 1_555 108.7 ? 
95  OE22 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE11 ? A CGU 29 ? L CGU 29 ? 1_555 58.5  ? 
96  OE12 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE12 ? A CGU 29 ? L CGU 29 ? 1_555 137.4 ? 
97  OE22 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE12 ? A CGU 29 ? L CGU 29 ? 1_555 102.9 ? 
98  OE11 ? A CGU 29 ? L CGU 29 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE12 ? A CGU 29 ? L CGU 29 ? 1_555 48.5  ? 
99  OE12 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 148.0 ? 
100 OE22 ? A CGU 25 ? L CGU 25 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 152.8 ? 
101 OE11 ? A CGU 29 ? L CGU 29 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 102.7 ? 
102 OE12 ? A CGU 29 ? L CGU 29 ? 1_555 CA ? N CA . ? L CA 210 ? 1_555 OE21 ? A CGU 29 ? L CGU 29 ? 1_555 70.2  ? 
103 OD2  ? A ASP 46 ? L ASP 46 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 O    ? A GLY 47 ? L GLY 47 ? 1_555 88.9  ? 
104 OD2  ? A ASP 46 ? L ASP 46 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OE1  ? A GLN 49 ? L GLN 49 ? 1_555 82.2  ? 
105 O    ? A GLY 47 ? L GLY 47 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OE1  ? A GLN 49 ? L GLN 49 ? 1_555 78.9  ? 
106 OD2  ? A ASP 46 ? L ASP 46 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD1  ? A ASP 63 ? L ASP 63 ? 1_555 157.5 ? 
107 O    ? A GLY 47 ? L GLY 47 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD1  ? A ASP 63 ? L ASP 63 ? 1_555 93.7  ? 
108 OE1  ? A GLN 49 ? L GLN 49 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD1  ? A ASP 63 ? L ASP 63 ? 1_555 76.4  ? 
109 OD2  ? A ASP 46 ? L ASP 46 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD2  ? A ASP 63 ? L ASP 63 ? 1_555 147.6 ? 
110 O    ? A GLY 47 ? L GLY 47 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD2  ? A ASP 63 ? L ASP 63 ? 1_555 95.7  ? 
111 OE1  ? A GLN 49 ? L GLN 49 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD2  ? A ASP 63 ? L ASP 63 ? 1_555 130.2 ? 
112 OD1  ? A ASP 63 ? L ASP 63 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 OD2  ? A ASP 63 ? L ASP 63 ? 1_555 54.3  ? 
113 OD2  ? A ASP 46 ? L ASP 46 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 O    ? A GLN 64 ? L GLN 64 ? 1_555 77.1  ? 
114 O    ? A GLY 47 ? L GLY 47 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 O    ? A GLN 64 ? L GLN 64 ? 1_555 164.5 ? 
115 OE1  ? A GLN 49 ? L GLN 49 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 O    ? A GLN 64 ? L GLN 64 ? 1_555 92.5  ? 
116 OD1  ? A ASP 63 ? L ASP 63 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 O    ? A GLN 64 ? L GLN 64 ? 1_555 96.8  ? 
117 OD2  ? A ASP 63 ? L ASP 63 ? 1_555 CA ? G CA . ? L CA 203 ? 1_555 O    ? A GLN 64 ? L GLN 64 ? 1_555 99.7  ? 
118 OE1  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE2  ? B GLU 58 ? H GLU 73 ? 1_555 44.4  ? 
119 OE1  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 O    ? B ASP 60 ? H ASP 75 ? 1_555 101.7 ? 
120 OE2  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 O    ? B ASP 60 ? H ASP 75 ? 1_555 80.6  ? 
121 OE1  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 O    ? B GLU 63 ? H GLU 78 ? 1_555 154.8 ? 
122 OE2  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 O    ? B GLU 63 ? H GLU 78 ? 1_555 159.5 ? 
123 O    ? B ASP 60 ? H ASP 75 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 O    ? B GLU 63 ? H GLU 78 ? 1_555 85.1  ? 
124 OE1  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE1  ? B GLU 68 ? H GLU 83 ? 1_555 68.2  ? 
125 OE2  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE1  ? B GLU 68 ? H GLU 83 ? 1_555 95.7  ? 
126 O    ? B ASP 60 ? H ASP 75 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE1  ? B GLU 68 ? H GLU 83 ? 1_555 167.7 ? 
127 O    ? B GLU 63 ? H GLU 78 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE1  ? B GLU 68 ? H GLU 83 ? 1_555 101.1 ? 
128 OE1  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE2  ? B GLU 68 ? H GLU 83 ? 1_555 101.0 ? 
129 OE2  ? B GLU 58 ? H GLU 73 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE2  ? B GLU 68 ? H GLU 83 ? 1_555 100.4 ? 
130 O    ? B ASP 60 ? H ASP 75 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE2  ? B GLU 68 ? H GLU 83 ? 1_555 147.7 ? 
131 O    ? B GLU 63 ? H GLU 78 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE2  ? B GLU 68 ? H GLU 83 ? 1_555 84.0  ? 
132 OE1  ? B GLU 68 ? H GLU 83 ? 1_555 CA ? O CA . ? H CA 301 ? 1_555 OE2  ? B GLU 68 ? H GLU 83 ? 1_555 44.4  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  CGU A 6   ? .   . .   . CGU L 6   ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
2  CGU A 7   ? .   . .   . CGU L 7   ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
3  CGU A 14  ? .   . .   . CGU L 14  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
4  CGU A 16  ? .   . .   . CGU L 16  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
5  CGU A 19  ? .   . .   . CGU L 19  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
6  CGU A 20  ? .   . .   . CGU L 20  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
7  CGU A 25  ? .   . .   . CGU L 25  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
8  CGU A 26  ? .   . .   . CGU L 26  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
9  CGU A 29  ? .   . .   . CGU L 29  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
10 CGU A 35  ? .   . .   . CGU L 35  ? 1_555 .   . .   . .     .  .  GLU 1 CGU Carboxylation   'Named protein modification' 
11 BGC E .   ? SER A 52  ? BGC L 201 ? 1_555 SER L 52  ? 1_555 C1 OG SER 3 BGC O-Glycosylation Carbohydrate                 
12 FUC F .   ? SER A 60  ? FUC L 202 ? 1_555 SER L 60  ? 1_555 C1 OG SER 1 FUC O-Glycosylation Carbohydrate                 
13 CYS A 17  ? CYS A 22  ? CYS L 17  ? 1_555 CYS L 22  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
14 CYS A 50  ? CYS A 61  ? CYS L 50  ? 1_555 CYS L 61  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
15 CYS A 55  ? CYS A 70  ? CYS L 55  ? 1_555 CYS L 70  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
16 CYS A 72  ? CYS A 81  ? CYS L 72  ? 1_555 CYS L 81  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
17 CYS A 91  ? CYS A 102 ? CYS L 91  ? 1_555 CYS L 102 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
18 CYS A 98  ? CYS A 112 ? CYS L 98  ? 1_555 CYS L 112 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
19 CYS A 114 ? CYS A 127 ? CYS L 114 ? 1_555 CYS L 127 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
20 CYS A 135 ? CYS B 110 ? CYS L 135 ? 1_555 CYS H 125 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
21 CYS B 7   ? CYS B 12  ? CYS H 22  ? 1_555 CYS H 27  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
22 CYS B 26  ? CYS B 42  ? CYS H 41  ? 1_555 CYS H 57  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
23 CYS B 158 ? CYS B 177 ? CYS H 173 ? 1_555 CYS H 192 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
24 CYS B 188 ? CYS B 216 ? CYS H 203 ? 1_555 CYS H 231 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
25 CYS C 44  ? CYS C 52  ? CYS T 49  ? 1_555 CYS T 57  ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
26 CYS D 92  ? CYS D 115 ? CYS U 186 ? 1_555 CYS U 209 ? 1_555 SG SG .   . .   None            'Disulfide bridge'           
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 SER 184 B . ? SER 199 H LYS 185 B ? LYS 200 H 1 -29.32 
2 ALA 217 B . ? ALA 232 H THR 218 B ? THR 233 H 1 19.49  
3 PHE 253 B . ? PHE 268 H PRO 254 B ? PRO 269 H 1 -5.44  
4 GLU 21  C . ? GLU 26  T PRO 22  C ? PRO 27  T 1 0.18   
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 7 ? 
AA6 ? 8 ? 
AA7 ? 3 ? 
AA8 ? 4 ? 
AA9 ? 3 ? 
AB1 ? 2 ? 
AB2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA6 6 7 ? anti-parallel 
AA6 7 8 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 60  ? ASP A 63  ? SER L 60  ASP L 63  
AA1 2 TYR A 68  ? PHE A 71  ? TYR L 68  PHE L 71  
AA2 1 PHE A 76  ? GLU A 77  ? PHE L 76  GLU L 77  
AA2 2 THR A 83  ? HIS A 84  ? THR L 83  HIS L 84  
AA3 1 TYR A 101 ? SER A 103 ? TYR L 101 SER L 103 
AA3 2 SER A 111 ? ARG A 113 ? SER L 111 ARG L 113 
AA4 1 TYR A 118 ? LEU A 120 ? TYR L 118 LEU L 120 
AA4 2 CYS A 127 ? PRO A 129 ? CYS L 127 PRO L 129 
AA5 1 LYS B 5   ? VAL B 6   ? LYS H 20  VAL H 21  
AA5 2 MET B 146 ? PRO B 151 ? MET H 161 PRO H 166 
AA5 3 PHE B 126 ? GLY B 131 ? PHE H 141 GLY H 146 
AA5 4 PRO B 195 ? TYR B 200 ? PRO H 210 TYR H 215 
AA5 5 THR B 203 ? TRP B 212 ? THR H 218 TRP H 227 
AA5 6 GLY B 223 ? ARG B 227 ? GLY H 238 ARG H 242 
AA5 7 MET B 175 ? ALA B 178 ? MET H 190 ALA H 193 
AA6 1 LEU B 248 ? ALA B 251 ? LEU H 263 ALA H 266 
AA6 2 GLN B 69  ? PRO B 79  ? GLN H 84  PRO H 94  
AA6 3 ALA B 92  ? LEU B 96  ? ALA H 107 LEU H 111 
AA6 4 TRP B 35  ? SER B 38  ? TRP H 50  SER H 53  
AA6 5 ALA B 23  ? LEU B 30  ? ALA H 38  LEU H 45  
AA6 6 GLN B 15  ? VAL B 20  ? GLN H 30  VAL H 35  
AA6 7 LEU B 52  ? LEU B 56  ? LEU H 67  LEU H 71  
AA6 8 GLN B 69  ? PRO B 79  ? GLN H 84  PRO H 94  
AA7 1 TYR C 5   ? THR C 12  ? TYR T 10  THR T 17  
AA7 2 LYS C 15  ? GLU C 21  ? LYS T 20  GLU T 26  
AA7 3 GLU C 51  ? ASP C 53  ? GLU T 56  ASP T 58  
AA8 1 LYS C 41  ? THR C 47  ? LYS T 46  THR T 52  
AA8 2 GLN C 27  ? THR C 35  ? GLN T 32  THR T 40  
AA8 3 TYR C 66  ? PRO C 74  ? TYR T 71  PRO T 79  
AA8 4 LEU D 3   ? ASN D 6   ? LEU U 93  ASN U 96  
AA9 1 ILE D 23  ? VAL D 29  ? ILE U 113 VAL U 119 
AA9 2 LYS D 32  ? VAL D 37  ? LYS U 122 VAL U 127 
AA9 3 GLU D 80  ? ASP D 84  ? GLU U 174 ASP U 178 
AB1 1 ARG D 41  ? ARG D 45  ? ARG U 131 ARG U 135 
AB1 2 PHE D 50  ? SER D 52  ? PHE U 140 SER U 142 
AB2 1 LYS D 72  ? THR D 76  ? LYS U 166 THR U 170 
AB2 2 ILE D 62  ? TRP D 68  ? ILE U 152 TRP U 158 
AB2 3 CYS D 92  ? VAL D 98  ? CYS U 186 VAL U 192 
AB2 4 GLU D 114 ? CYS D 115 ? GLU U 208 CYS U 209 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N SER A 60  ? N SER L 60  O PHE A 71  ? O PHE L 71  
AA2 1 2 N GLU A 77  ? N GLU L 77  O THR A 83  ? O THR L 83  
AA3 1 2 N SER A 103 ? N SER L 103 O SER A 111 ? O SER L 111 
AA4 1 2 N SER A 119 ? N SER L 119 O THR A 128 ? O THR L 128 
AA5 1 2 N LYS B 5   ? N LYS H 20  O VAL B 147 ? O VAL H 162 
AA5 2 3 O VAL B 150 ? O VAL H 165 N SER B 127 ? N SER H 142 
AA5 3 4 N LEU B 128 ? N LEU H 143 O ALA B 197 ? O ALA H 212 
AA5 4 5 N THR B 198 ? N THR H 213 O TYR B 205 ? O TYR H 220 
AA5 5 6 N TRP B 212 ? N TRP H 227 O VAL B 224 ? O VAL H 239 
AA5 6 7 O GLY B 223 ? O GLY H 238 N ALA B 178 ? N ALA H 193 
AA6 1 2 O LEU B 249 ? O LEU H 264 N VAL B 76  ? N VAL H 91  
AA6 2 3 N ILE B 77  ? N ILE H 92  O LEU B 93  ? O LEU H 108 
AA6 3 4 O ALA B 92  ? O ALA H 107 N SER B 38  ? N SER H 53  
AA6 4 5 O VAL B 37  ? O VAL H 52  N THR B 29  ? N THR H 44  
AA6 5 6 O LEU B 25  ? O LEU H 40  N LEU B 18  ? N LEU H 33  
AA6 6 7 N LEU B 17  ? N LEU H 32  O VAL B 55  ? O VAL H 70  
AA6 7 8 N ALA B 54  ? N ALA H 69  O ARG B 71  ? O ARG H 86  
AA7 1 2 N TYR C 5   ? N TYR T 10  O GLU C 21  ? O GLU T 26  
AA7 2 3 N LEU C 18  ? N LEU T 23  O CYS C 52  ? O CYS T 57  
AA8 1 2 O LYS C 43  ? O LYS T 48  N VAL C 31  ? N VAL T 36  
AA8 2 3 N THR C 30  ? N THR T 35  O PHE C 71  ? O PHE T 76  
AA8 3 4 N SER C 72  ? N SER T 77  O LEU D 3   ? O LEU U 93  
AA9 1 2 N VAL D 29  ? N VAL U 119 O LYS D 32  ? O LYS U 122 
AA9 2 3 N VAL D 33  ? N VAL U 123 O ILE D 83  ? O ILE U 177 
AB1 1 2 N VAL D 44  ? N VAL U 134 O LEU D 51  ? O LEU U 141 
AB2 1 2 O ALA D 74  ? O ALA U 168 N LEU D 65  ? N LEU U 155 
AB2 2 3 N ILE D 62  ? N ILE U 152 O VAL D 98  ? O VAL U 192 
AB2 3 4 N PHE D 93  ? N PHE U 187 O GLU D 114 ? O GLU U 208 
# 
_pdbx_entry_details.entry_id                   8UUD 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 OD1  L ASN 2   ? ? OE22 L CGU 26  ? ? 1.36 
2  1 O    L LYS 18  ? ? N    L CGU 19  ? ? 1.44 
3  1 O    L LEU 13  ? ? N    L CGU 14  ? ? 1.46 
4  1 N    H SER 199 ? ? O    H LYS 200 ? ? 1.59 
5  1 O    H GLN 229 ? ? N    H GLY 230 ? ? 1.60 
6  1 O    L ARG 28  ? ? N    L CGU 29  ? ? 1.72 
7  1 C    H GLY 198 ? ? O    H LYS 200 ? ? 1.76 
8  1 CB   L CGU 26  ? ? O    L HOH 310 ? ? 1.95 
9  1 OE21 L CGU 25  ? ? NH2  L ARG 28  ? ? 2.03 
10 1 O    H ALA 193 ? ? N    H GLY 238 ? ? 2.12 
11 1 O    H GLY 198 ? ? O    H LYS 200 ? ? 2.16 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 C L CGU 25 ? ? N L CGU 26 ? ? 1.479 1.336 0.143 0.023 Y 
2 1 C L ALA 34 ? ? N L CGU 35 ? ? 1.477 1.336 0.141 0.023 Y 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 CA L CGU 6   ? ? C  L CGU 6   ? ? N  L CGU 7   ? ? 89.56  117.20 -27.64 2.20 Y 
2  1 O  L CGU 6   ? ? C  L CGU 6   ? ? N  L CGU 7   ? ? 95.72  122.70 -26.98 1.60 Y 
3  1 C  L CGU 6   ? ? N  L CGU 7   ? ? CA L CGU 7   ? ? 154.33 121.70 32.63  2.50 Y 
4  1 C  L CGU 7   ? ? N  L LEU 8   ? ? CA L LEU 8   ? ? 139.46 121.70 17.76  2.50 Y 
5  1 CA L LEU 13  ? ? C  L LEU 13  ? ? N  L CGU 14  ? ? 142.78 117.20 25.58  2.20 Y 
6  1 O  L LEU 13  ? ? C  L LEU 13  ? ? N  L CGU 14  ? ? 65.41  122.70 -57.29 1.60 Y 
7  1 C  L LEU 13  ? ? N  L CGU 14  ? ? CA L CGU 14  ? ? 163.27 121.70 41.57  2.50 Y 
8  1 CA L CGU 14  ? ? C  L CGU 14  ? ? N  L ARG 15  ? ? 136.14 117.20 18.94  2.20 Y 
9  1 O  L CGU 14  ? ? C  L CGU 14  ? ? N  L ARG 15  ? ? 105.47 122.70 -17.23 1.60 Y 
10 1 O  L ARG 15  ? ? C  L ARG 15  ? ? N  L CGU 16  ? ? 102.86 122.70 -19.84 1.60 Y 
11 1 CA L CGU 16  ? ? C  L CGU 16  ? ? N  L CYS 17  ? ? 135.83 117.20 18.63  2.20 Y 
12 1 O  L CGU 16  ? ? C  L CGU 16  ? ? N  L CYS 17  ? ? 100.59 122.70 -22.11 1.60 Y 
13 1 CA L LYS 18  ? ? C  L LYS 18  ? ? N  L CGU 19  ? ? 175.71 117.20 58.51  2.20 Y 
14 1 O  L LYS 18  ? ? C  L LYS 18  ? ? N  L CGU 19  ? ? 64.07  122.70 -58.63 1.60 Y 
15 1 C  L LYS 18  ? ? N  L CGU 19  ? ? CA L CGU 19  ? ? 148.69 121.70 26.99  2.50 Y 
16 1 C  L CGU 19  ? ? N  L CGU 20  ? ? CA L CGU 20  ? ? 153.75 121.70 32.05  2.50 Y 
17 1 O  L CGU 20  ? ? C  L CGU 20  ? ? N  L GLN 21  ? ? 86.19  122.70 -36.51 1.60 Y 
18 1 O  L PHE 24  ? ? C  L PHE 24  ? ? N  L CGU 25  ? ? 94.32  122.70 -28.38 1.60 Y 
19 1 CA L CGU 25  ? ? C  L CGU 25  ? ? N  L CGU 26  ? ? 146.63 117.20 29.43  2.20 Y 
20 1 O  L CGU 25  ? ? C  L CGU 25  ? ? N  L CGU 26  ? ? 100.86 122.70 -21.84 1.60 Y 
21 1 CA L CGU 26  ? ? C  L CGU 26  ? ? N  L ALA 27  ? ? 136.18 117.20 18.98  2.20 Y 
22 1 O  L CGU 26  ? ? C  L CGU 26  ? ? N  L ALA 27  ? ? 88.15  122.70 -34.55 1.60 Y 
23 1 C  L CGU 26  ? ? N  L ALA 27  ? ? CA L ALA 27  ? ? 156.75 121.70 35.05  2.50 Y 
24 1 CA L ARG 28  ? ? C  L ARG 28  ? ? N  L CGU 29  ? ? 138.91 117.20 21.71  2.20 Y 
25 1 O  L ARG 28  ? ? C  L ARG 28  ? ? N  L CGU 29  ? ? 79.04  122.70 -43.66 1.60 Y 
26 1 C  L ARG 28  ? ? N  L CGU 29  ? ? CA L CGU 29  ? ? 146.38 121.70 24.68  2.50 Y 
27 1 CA L ALA 34  ? ? C  L ALA 34  ? ? N  L CGU 35  ? ? 150.12 117.20 32.92  2.20 Y 
28 1 O  L ALA 34  ? ? C  L ALA 34  ? ? N  L CGU 35  ? ? 91.21  122.70 -31.49 1.60 Y 
29 1 C  L CGU 35  ? ? N  L ARG 36  ? ? CA L ARG 36  ? ? 151.05 121.70 29.35  2.50 Y 
30 1 N  H TYR 195 ? ? CA H TYR 195 ? ? CB H TYR 195 ? ? 127.90 110.60 17.30  1.80 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PHE L 4   ? ? -58.69  95.83   
2  1 LEU L 5   ? ? 142.13  -82.68  
3  1 LEU L 8   ? ? -24.93  -52.36  
4  1 CGU L 14  ? ? -70.24  -131.20 
5  1 ARG L 15  ? ? 17.87   52.37   
6  1 CGU L 16  ? ? 172.10  -59.73  
7  1 LYS L 18  ? ? -119.67 -77.11  
8  1 CGU L 20  ? ? -123.28 -168.69 
9  1 CGU L 26  ? ? -31.65  -20.87  
10 1 ARG L 28  ? ? -146.14 18.63   
11 1 CGU L 29  ? ? -15.26  -6.80   
12 1 ILE L 30  ? ? -144.80 -64.91  
13 1 LYS L 32  ? ? 65.88   -69.82  
14 1 GLN L 100 ? ? -116.31 -103.37 
15 1 ASN H 47  ? ? -168.68 -162.66 
16 1 LYS H 62  ? ? -145.33 22.12   
17 1 TRP H 64  ? ? -63.42  18.62   
18 1 HIS H 74  ? ? -142.99 -64.82  
19 1 THR H 135 ? ? -123.84 -60.74  
20 1 GLN H 176 ? ? -156.77 -24.13  
21 1 SER H 226 ? ? -123.10 -66.40  
22 1 PHE T 19  ? ? 74.65   -6.65   
23 1 ASN U 137 ? ? 45.81   81.92   
24 1 THR U 172 ? ? -115.32 -148.96 
# 
loop_
_pdbx_validate_peptide_omega.id 
_pdbx_validate_peptide_omega.PDB_model_num 
_pdbx_validate_peptide_omega.auth_comp_id_1 
_pdbx_validate_peptide_omega.auth_asym_id_1 
_pdbx_validate_peptide_omega.auth_seq_id_1 
_pdbx_validate_peptide_omega.PDB_ins_code_1 
_pdbx_validate_peptide_omega.label_alt_id_1 
_pdbx_validate_peptide_omega.auth_comp_id_2 
_pdbx_validate_peptide_omega.auth_asym_id_2 
_pdbx_validate_peptide_omega.auth_seq_id_2 
_pdbx_validate_peptide_omega.PDB_ins_code_2 
_pdbx_validate_peptide_omega.label_alt_id_2 
_pdbx_validate_peptide_omega.omega 
1 1 LEU L 5   ? ? CGU L 6   ? ? -55.15  
2 1 CGU L 6   ? ? CGU L 7   ? ? -147.10 
3 1 CGU L 7   ? ? LEU L 8   ? ? 129.67  
4 1 CGU L 14  ? ? ARG L 15  ? ? 84.59   
5 1 LYS L 18  ? ? CGU L 19  ? ? -135.61 
6 1 ARG L 28  ? ? CGU L 29  ? ? 84.76   
7 1 ALA L 34  ? ? CGU L 35  ? ? 135.08  
8 1 GLY H 194 ? ? TYR H 195 ? ? 139.35  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG L 28  ? ? 0.097 'SIDE CHAIN' 
2 1 ARG H 140 ? ? 0.095 'SIDE CHAIN' 
# 
loop_
_pdbx_validate_main_chain_plane.id 
_pdbx_validate_main_chain_plane.PDB_model_num 
_pdbx_validate_main_chain_plane.auth_comp_id 
_pdbx_validate_main_chain_plane.auth_asym_id 
_pdbx_validate_main_chain_plane.auth_seq_id 
_pdbx_validate_main_chain_plane.PDB_ins_code 
_pdbx_validate_main_chain_plane.label_alt_id 
_pdbx_validate_main_chain_plane.improper_torsion_angle 
1  1 CGU L 6  ? ? -36.11 
2  1 LEU L 13 ? ? -63.05 
3  1 CGU L 14 ? ? -11.48 
4  1 ARG L 15 ? ? 29.86  
5  1 CGU L 16 ? ? 23.03  
6  1 LYS L 18 ? ? -60.48 
7  1 CGU L 20 ? ? -41.96 
8  1 PHE L 24 ? ? 34.51  
9  1 CGU L 26 ? ? -36.19 
10 1 ARG L 28 ? ? -49.60 
11 1 ALA L 34 ? ? -25.98 
12 1 CGU L 35 ? ? 14.24  
# 
loop_
_pdbx_validate_polymer_linkage.id 
_pdbx_validate_polymer_linkage.PDB_model_num 
_pdbx_validate_polymer_linkage.auth_atom_id_1 
_pdbx_validate_polymer_linkage.auth_asym_id_1 
_pdbx_validate_polymer_linkage.auth_comp_id_1 
_pdbx_validate_polymer_linkage.auth_seq_id_1 
_pdbx_validate_polymer_linkage.PDB_ins_code_1 
_pdbx_validate_polymer_linkage.label_alt_id_1 
_pdbx_validate_polymer_linkage.auth_atom_id_2 
_pdbx_validate_polymer_linkage.auth_asym_id_2 
_pdbx_validate_polymer_linkage.auth_comp_id_2 
_pdbx_validate_polymer_linkage.auth_seq_id_2 
_pdbx_validate_polymer_linkage.PDB_ins_code_2 
_pdbx_validate_polymer_linkage.label_alt_id_2 
_pdbx_validate_polymer_linkage.dist 
1  1 C H VAL 35  ? ? N H ASN 36  ? ? 1.91 
2  1 C H ARG 153 ? ? N H GLY 154 ? ? 3.01 
3  1 C H CYS 192 ? ? N H ALA 193 ? ? 1.94 
4  1 C H ALA 193 ? ? N H GLY 194 ? ? 2.90 
5  1 C H TYR 195 ? ? N H SER 196 ? ? 4.24 
6  1 C H GLY 198 ? ? N H SER 199 ? ? 2.75 
7  1 C H LYS 200 ? ? N H ASP 201 ? ? 5.38 
8  1 C H GLN 229 ? ? N H GLY 230 ? ? 2.42 
9  1 C H CYS 231 ? ? N H ALA 232 ? ? 1.95 
10 1 C H THR 233 ? ? N H VAL 234 ? ? 5.01 
11 1 C U TRP 158 ? ? N U SER 163 ? ? 9.09 
# 
loop_
_pdbx_struct_mod_residue.id 
_pdbx_struct_mod_residue.label_asym_id 
_pdbx_struct_mod_residue.label_comp_id 
_pdbx_struct_mod_residue.label_seq_id 
_pdbx_struct_mod_residue.auth_asym_id 
_pdbx_struct_mod_residue.auth_comp_id 
_pdbx_struct_mod_residue.auth_seq_id 
_pdbx_struct_mod_residue.PDB_ins_code 
_pdbx_struct_mod_residue.parent_comp_id 
_pdbx_struct_mod_residue.details 
1  A CGU 6  L CGU 6  ? GLU 'modified residue' 
2  A CGU 7  L CGU 7  ? GLU 'modified residue' 
3  A CGU 14 L CGU 14 ? GLU 'modified residue' 
4  A CGU 16 L CGU 16 ? GLU 'modified residue' 
5  A CGU 19 L CGU 19 ? GLU 'modified residue' 
6  A CGU 20 L CGU 20 ? GLU 'modified residue' 
7  A CGU 25 L CGU 25 ? GLU 'modified residue' 
8  A CGU 26 L CGU 26 ? GLU 'modified residue' 
9  A CGU 29 L CGU 29 ? GLU 'modified residue' 
10 A CGU 35 L CGU 35 ? GLU 'modified residue' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? H HOH 450 ? 5.81 .    
2 1 O ? H HOH 451 ? .    6.42 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
BGC C2   C  N R 74  
BGC C3   C  N S 75  
BGC C4   C  N S 76  
BGC C5   C  N R 77  
BGC C6   C  N N 78  
BGC C1   C  N R 79  
BGC O1   O  N N 80  
BGC O2   O  N N 81  
BGC O3   O  N N 82  
BGC O4   O  N N 83  
BGC O5   O  N N 84  
BGC O6   O  N N 85  
BGC H2   H  N N 86  
BGC H3   H  N N 87  
BGC H4   H  N N 88  
BGC H5   H  N N 89  
BGC H61  H  N N 90  
BGC H62  H  N N 91  
BGC H1   H  N N 92  
BGC HO1  H  N N 93  
BGC HO2  H  N N 94  
BGC HO3  H  N N 95  
BGC HO4  H  N N 96  
BGC HO6  H  N N 97  
CA  CA   CA N N 98  
CGU N    N  N N 99  
CGU CA   C  N S 100 
CGU C    C  N N 101 
CGU O    O  N N 102 
CGU OXT  O  N N 103 
CGU CB   C  N N 104 
CGU CG   C  N N 105 
CGU CD1  C  N N 106 
CGU CD2  C  N N 107 
CGU OE11 O  N N 108 
CGU OE12 O  N N 109 
CGU OE21 O  N N 110 
CGU OE22 O  N N 111 
CGU H    H  N N 112 
CGU H2   H  N N 113 
CGU HA   H  N N 114 
CGU HXT  H  N N 115 
CGU HB2  H  N N 116 
CGU HB3  H  N N 117 
CGU HG   H  N N 118 
CGU HE12 H  N N 119 
CGU HE22 H  N N 120 
CYS N    N  N N 121 
CYS CA   C  N R 122 
CYS C    C  N N 123 
CYS O    O  N N 124 
CYS CB   C  N N 125 
CYS SG   S  N N 126 
CYS OXT  O  N N 127 
CYS H    H  N N 128 
CYS H2   H  N N 129 
CYS HA   H  N N 130 
CYS HB2  H  N N 131 
CYS HB3  H  N N 132 
CYS HG   H  N N 133 
CYS HXT  H  N N 134 
FUC C1   C  N R 135 
FUC C2   C  N S 136 
FUC C3   C  N R 137 
FUC C4   C  N S 138 
FUC C5   C  N S 139 
FUC C6   C  N N 140 
FUC O1   O  N N 141 
FUC O2   O  N N 142 
FUC O3   O  N N 143 
FUC O4   O  N N 144 
FUC O5   O  N N 145 
FUC H1   H  N N 146 
FUC H2   H  N N 147 
FUC H3   H  N N 148 
FUC H4   H  N N 149 
FUC H5   H  N N 150 
FUC H61  H  N N 151 
FUC H62  H  N N 152 
FUC H63  H  N N 153 
FUC HO1  H  N N 154 
FUC HO2  H  N N 155 
FUC HO3  H  N N 156 
FUC HO4  H  N N 157 
GLN N    N  N N 158 
GLN CA   C  N S 159 
GLN C    C  N N 160 
GLN O    O  N N 161 
GLN CB   C  N N 162 
GLN CG   C  N N 163 
GLN CD   C  N N 164 
GLN OE1  O  N N 165 
GLN NE2  N  N N 166 
GLN OXT  O  N N 167 
GLN H    H  N N 168 
GLN H2   H  N N 169 
GLN HA   H  N N 170 
GLN HB2  H  N N 171 
GLN HB3  H  N N 172 
GLN HG2  H  N N 173 
GLN HG3  H  N N 174 
GLN HE21 H  N N 175 
GLN HE22 H  N N 176 
GLN HXT  H  N N 177 
GLU N    N  N N 178 
GLU CA   C  N S 179 
GLU C    C  N N 180 
GLU O    O  N N 181 
GLU CB   C  N N 182 
GLU CG   C  N N 183 
GLU CD   C  N N 184 
GLU OE1  O  N N 185 
GLU OE2  O  N N 186 
GLU OXT  O  N N 187 
GLU H    H  N N 188 
GLU H2   H  N N 189 
GLU HA   H  N N 190 
GLU HB2  H  N N 191 
GLU HB3  H  N N 192 
GLU HG2  H  N N 193 
GLU HG3  H  N N 194 
GLU HE2  H  N N 195 
GLU HXT  H  N N 196 
GLY N    N  N N 197 
GLY CA   C  N N 198 
GLY C    C  N N 199 
GLY O    O  N N 200 
GLY OXT  O  N N 201 
GLY H    H  N N 202 
GLY H2   H  N N 203 
GLY HA2  H  N N 204 
GLY HA3  H  N N 205 
GLY HXT  H  N N 206 
HIS N    N  N N 207 
HIS CA   C  N S 208 
HIS C    C  N N 209 
HIS O    O  N N 210 
HIS CB   C  N N 211 
HIS CG   C  Y N 212 
HIS ND1  N  Y N 213 
HIS CD2  C  Y N 214 
HIS CE1  C  Y N 215 
HIS NE2  N  Y N 216 
HIS OXT  O  N N 217 
HIS H    H  N N 218 
HIS H2   H  N N 219 
HIS HA   H  N N 220 
HIS HB2  H  N N 221 
HIS HB3  H  N N 222 
HIS HD1  H  N N 223 
HIS HD2  H  N N 224 
HIS HE1  H  N N 225 
HIS HE2  H  N N 226 
HIS HXT  H  N N 227 
HOH O    O  N N 228 
HOH H1   H  N N 229 
HOH H2   H  N N 230 
ILE N    N  N N 231 
ILE CA   C  N S 232 
ILE C    C  N N 233 
ILE O    O  N N 234 
ILE CB   C  N S 235 
ILE CG1  C  N N 236 
ILE CG2  C  N N 237 
ILE CD1  C  N N 238 
ILE OXT  O  N N 239 
ILE H    H  N N 240 
ILE H2   H  N N 241 
ILE HA   H  N N 242 
ILE HB   H  N N 243 
ILE HG12 H  N N 244 
ILE HG13 H  N N 245 
ILE HG21 H  N N 246 
ILE HG22 H  N N 247 
ILE HG23 H  N N 248 
ILE HD11 H  N N 249 
ILE HD12 H  N N 250 
ILE HD13 H  N N 251 
ILE HXT  H  N N 252 
LEU N    N  N N 253 
LEU CA   C  N S 254 
LEU C    C  N N 255 
LEU O    O  N N 256 
LEU CB   C  N N 257 
LEU CG   C  N N 258 
LEU CD1  C  N N 259 
LEU CD2  C  N N 260 
LEU OXT  O  N N 261 
LEU H    H  N N 262 
LEU H2   H  N N 263 
LEU HA   H  N N 264 
LEU HB2  H  N N 265 
LEU HB3  H  N N 266 
LEU HG   H  N N 267 
LEU HD11 H  N N 268 
LEU HD12 H  N N 269 
LEU HD13 H  N N 270 
LEU HD21 H  N N 271 
LEU HD22 H  N N 272 
LEU HD23 H  N N 273 
LEU HXT  H  N N 274 
LYS N    N  N N 275 
LYS CA   C  N S 276 
LYS C    C  N N 277 
LYS O    O  N N 278 
LYS CB   C  N N 279 
LYS CG   C  N N 280 
LYS CD   C  N N 281 
LYS CE   C  N N 282 
LYS NZ   N  N N 283 
LYS OXT  O  N N 284 
LYS H    H  N N 285 
LYS H2   H  N N 286 
LYS HA   H  N N 287 
LYS HB2  H  N N 288 
LYS HB3  H  N N 289 
LYS HG2  H  N N 290 
LYS HG3  H  N N 291 
LYS HD2  H  N N 292 
LYS HD3  H  N N 293 
LYS HE2  H  N N 294 
LYS HE3  H  N N 295 
LYS HZ1  H  N N 296 
LYS HZ2  H  N N 297 
LYS HZ3  H  N N 298 
LYS HXT  H  N N 299 
MET N    N  N N 300 
MET CA   C  N S 301 
MET C    C  N N 302 
MET O    O  N N 303 
MET CB   C  N N 304 
MET CG   C  N N 305 
MET SD   S  N N 306 
MET CE   C  N N 307 
MET OXT  O  N N 308 
MET H    H  N N 309 
MET H2   H  N N 310 
MET HA   H  N N 311 
MET HB2  H  N N 312 
MET HB3  H  N N 313 
MET HG2  H  N N 314 
MET HG3  H  N N 315 
MET HE1  H  N N 316 
MET HE2  H  N N 317 
MET HE3  H  N N 318 
MET HXT  H  N N 319 
PHE N    N  N N 320 
PHE CA   C  N S 321 
PHE C    C  N N 322 
PHE O    O  N N 323 
PHE CB   C  N N 324 
PHE CG   C  Y N 325 
PHE CD1  C  Y N 326 
PHE CD2  C  Y N 327 
PHE CE1  C  Y N 328 
PHE CE2  C  Y N 329 
PHE CZ   C  Y N 330 
PHE OXT  O  N N 331 
PHE H    H  N N 332 
PHE H2   H  N N 333 
PHE HA   H  N N 334 
PHE HB2  H  N N 335 
PHE HB3  H  N N 336 
PHE HD1  H  N N 337 
PHE HD2  H  N N 338 
PHE HE1  H  N N 339 
PHE HE2  H  N N 340 
PHE HZ   H  N N 341 
PHE HXT  H  N N 342 
PRO N    N  N N 343 
PRO CA   C  N S 344 
PRO C    C  N N 345 
PRO O    O  N N 346 
PRO CB   C  N N 347 
PRO CG   C  N N 348 
PRO CD   C  N N 349 
PRO OXT  O  N N 350 
PRO H    H  N N 351 
PRO HA   H  N N 352 
PRO HB2  H  N N 353 
PRO HB3  H  N N 354 
PRO HG2  H  N N 355 
PRO HG3  H  N N 356 
PRO HD2  H  N N 357 
PRO HD3  H  N N 358 
PRO HXT  H  N N 359 
SER N    N  N N 360 
SER CA   C  N S 361 
SER C    C  N N 362 
SER O    O  N N 363 
SER CB   C  N N 364 
SER OG   O  N N 365 
SER OXT  O  N N 366 
SER H    H  N N 367 
SER H2   H  N N 368 
SER HA   H  N N 369 
SER HB2  H  N N 370 
SER HB3  H  N N 371 
SER HG   H  N N 372 
SER HXT  H  N N 373 
THR N    N  N N 374 
THR CA   C  N S 375 
THR C    C  N N 376 
THR O    O  N N 377 
THR CB   C  N R 378 
THR OG1  O  N N 379 
THR CG2  C  N N 380 
THR OXT  O  N N 381 
THR H    H  N N 382 
THR H2   H  N N 383 
THR HA   H  N N 384 
THR HB   H  N N 385 
THR HG1  H  N N 386 
THR HG21 H  N N 387 
THR HG22 H  N N 388 
THR HG23 H  N N 389 
THR HXT  H  N N 390 
TRP N    N  N N 391 
TRP CA   C  N S 392 
TRP C    C  N N 393 
TRP O    O  N N 394 
TRP CB   C  N N 395 
TRP CG   C  Y N 396 
TRP CD1  C  Y N 397 
TRP CD2  C  Y N 398 
TRP NE1  N  Y N 399 
TRP CE2  C  Y N 400 
TRP CE3  C  Y N 401 
TRP CZ2  C  Y N 402 
TRP CZ3  C  Y N 403 
TRP CH2  C  Y N 404 
TRP OXT  O  N N 405 
TRP H    H  N N 406 
TRP H2   H  N N 407 
TRP HA   H  N N 408 
TRP HB2  H  N N 409 
TRP HB3  H  N N 410 
TRP HD1  H  N N 411 
TRP HE1  H  N N 412 
TRP HE3  H  N N 413 
TRP HZ2  H  N N 414 
TRP HZ3  H  N N 415 
TRP HH2  H  N N 416 
TRP HXT  H  N N 417 
TYR N    N  N N 418 
TYR CA   C  N S 419 
TYR C    C  N N 420 
TYR O    O  N N 421 
TYR CB   C  N N 422 
TYR CG   C  Y N 423 
TYR CD1  C  Y N 424 
TYR CD2  C  Y N 425 
TYR CE1  C  Y N 426 
TYR CE2  C  Y N 427 
TYR CZ   C  Y N 428 
TYR OH   O  N N 429 
TYR OXT  O  N N 430 
TYR H    H  N N 431 
TYR H2   H  N N 432 
TYR HA   H  N N 433 
TYR HB2  H  N N 434 
TYR HB3  H  N N 435 
TYR HD1  H  N N 436 
TYR HD2  H  N N 437 
TYR HE1  H  N N 438 
TYR HE2  H  N N 439 
TYR HH   H  N N 440 
TYR HXT  H  N N 441 
VAL N    N  N N 442 
VAL CA   C  N S 443 
VAL C    C  N N 444 
VAL O    O  N N 445 
VAL CB   C  N N 446 
VAL CG1  C  N N 447 
VAL CG2  C  N N 448 
VAL OXT  O  N N 449 
VAL H    H  N N 450 
VAL H2   H  N N 451 
VAL HA   H  N N 452 
VAL HB   H  N N 453 
VAL HG11 H  N N 454 
VAL HG12 H  N N 455 
VAL HG13 H  N N 456 
VAL HG21 H  N N 457 
VAL HG22 H  N N 458 
VAL HG23 H  N N 459 
VAL HXT  H  N N 460 
XGX C1   C  Y N 461 
XGX C2   C  Y N 462 
XGX C3   C  Y N 463 
XGX C4   C  Y N 464 
XGX C5   C  Y N 465 
XGX C6   C  Y N 466 
XGX C7   C  N N 467 
XGX N1   N  N N 468 
XGX C8   C  Y N 469 
XGX C9   C  Y N 470 
XGX C10  C  Y N 471 
XGX C11  C  Y N 472 
XGX C12  C  Y N 473 
XGX C13  C  Y N 474 
XGX C14  C  N N 475 
XGX O1   O  N N 476 
XGX O2   O  N N 477 
XGX C15  C  N N 478 
XGX N2   N  N N 479 
XGX O3   O  N N 480 
XGX C16  C  N N 481 
XGX C17  C  N N 482 
XGX C18  C  N N 483 
XGX C19  C  N N 484 
XGX C20  C  Y N 485 
XGX C21  C  Y N 486 
XGX C22  C  Y N 487 
XGX C23  C  Y N 488 
XGX C24  C  Y N 489 
XGX C25  C  Y N 490 
XGX C26  C  N N 491 
XGX C27  C  N N 492 
XGX O4   O  N N 493 
XGX C28  C  N N 494 
XGX N3   N  N N 495 
XGX N4   N  N N 496 
XGX H1   H  N N 497 
XGX H2   H  N N 498 
XGX H3   H  N N 499 
XGX H4   H  N N 500 
XGX H5   H  N N 501 
XGX H6   H  N N 502 
XGX H7   H  N N 503 
XGX H8   H  N N 504 
XGX H9   H  N N 505 
XGX H10  H  N N 506 
XGX H11  H  N N 507 
XGX H12  H  N N 508 
XGX H13  H  N N 509 
XGX H14  H  N N 510 
XGX H15  H  N N 511 
XGX H16  H  N N 512 
XGX H17  H  N N 513 
XGX H18  H  N N 514 
XGX H19  H  N N 515 
XGX H20  H  N N 516 
XGX H21  H  N N 517 
XGX H22  H  N N 518 
XGX H23  H  N N 519 
XGX H24  H  N N 520 
XGX H25  H  N N 521 
XGX H26  H  N N 522 
XGX H27  H  N N 523 
XGX H28  H  N N 524 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N    CA   sing N N 1   
ALA N    H    sing N N 2   
ALA N    H2   sing N N 3   
ALA CA   C    sing N N 4   
ALA CA   CB   sing N N 5   
ALA CA   HA   sing N N 6   
ALA C    O    doub N N 7   
ALA C    OXT  sing N N 8   
ALA CB   HB1  sing N N 9   
ALA CB   HB2  sing N N 10  
ALA CB   HB3  sing N N 11  
ALA OXT  HXT  sing N N 12  
ARG N    CA   sing N N 13  
ARG N    H    sing N N 14  
ARG N    H2   sing N N 15  
ARG CA   C    sing N N 16  
ARG CA   CB   sing N N 17  
ARG CA   HA   sing N N 18  
ARG C    O    doub N N 19  
ARG C    OXT  sing N N 20  
ARG CB   CG   sing N N 21  
ARG CB   HB2  sing N N 22  
ARG CB   HB3  sing N N 23  
ARG CG   CD   sing N N 24  
ARG CG   HG2  sing N N 25  
ARG CG   HG3  sing N N 26  
ARG CD   NE   sing N N 27  
ARG CD   HD2  sing N N 28  
ARG CD   HD3  sing N N 29  
ARG NE   CZ   sing N N 30  
ARG NE   HE   sing N N 31  
ARG CZ   NH1  sing N N 32  
ARG CZ   NH2  doub N N 33  
ARG NH1  HH11 sing N N 34  
ARG NH1  HH12 sing N N 35  
ARG NH2  HH21 sing N N 36  
ARG NH2  HH22 sing N N 37  
ARG OXT  HXT  sing N N 38  
ASN N    CA   sing N N 39  
ASN N    H    sing N N 40  
ASN N    H2   sing N N 41  
ASN CA   C    sing N N 42  
ASN CA   CB   sing N N 43  
ASN CA   HA   sing N N 44  
ASN C    O    doub N N 45  
ASN C    OXT  sing N N 46  
ASN CB   CG   sing N N 47  
ASN CB   HB2  sing N N 48  
ASN CB   HB3  sing N N 49  
ASN CG   OD1  doub N N 50  
ASN CG   ND2  sing N N 51  
ASN ND2  HD21 sing N N 52  
ASN ND2  HD22 sing N N 53  
ASN OXT  HXT  sing N N 54  
ASP N    CA   sing N N 55  
ASP N    H    sing N N 56  
ASP N    H2   sing N N 57  
ASP CA   C    sing N N 58  
ASP CA   CB   sing N N 59  
ASP CA   HA   sing N N 60  
ASP C    O    doub N N 61  
ASP C    OXT  sing N N 62  
ASP CB   CG   sing N N 63  
ASP CB   HB2  sing N N 64  
ASP CB   HB3  sing N N 65  
ASP CG   OD1  doub N N 66  
ASP CG   OD2  sing N N 67  
ASP OD2  HD2  sing N N 68  
ASP OXT  HXT  sing N N 69  
BGC C2   C3   sing N N 70  
BGC C2   C1   sing N N 71  
BGC C2   O2   sing N N 72  
BGC C2   H2   sing N N 73  
BGC C3   C4   sing N N 74  
BGC C3   O3   sing N N 75  
BGC C3   H3   sing N N 76  
BGC C4   C5   sing N N 77  
BGC C4   O4   sing N N 78  
BGC C4   H4   sing N N 79  
BGC C5   C6   sing N N 80  
BGC C5   O5   sing N N 81  
BGC C5   H5   sing N N 82  
BGC C6   O6   sing N N 83  
BGC C6   H61  sing N N 84  
BGC C6   H62  sing N N 85  
BGC C1   O1   sing N N 86  
BGC C1   O5   sing N N 87  
BGC C1   H1   sing N N 88  
BGC O1   HO1  sing N N 89  
BGC O2   HO2  sing N N 90  
BGC O3   HO3  sing N N 91  
BGC O4   HO4  sing N N 92  
BGC O6   HO6  sing N N 93  
CGU N    CA   sing N N 94  
CGU N    H    sing N N 95  
CGU N    H2   sing N N 96  
CGU CA   C    sing N N 97  
CGU CA   CB   sing N N 98  
CGU CA   HA   sing N N 99  
CGU C    O    doub N N 100 
CGU C    OXT  sing N N 101 
CGU OXT  HXT  sing N N 102 
CGU CB   CG   sing N N 103 
CGU CB   HB2  sing N N 104 
CGU CB   HB3  sing N N 105 
CGU CG   CD1  sing N N 106 
CGU CG   CD2  sing N N 107 
CGU CG   HG   sing N N 108 
CGU CD1  OE11 doub N N 109 
CGU CD1  OE12 sing N N 110 
CGU CD2  OE21 doub N N 111 
CGU CD2  OE22 sing N N 112 
CGU OE12 HE12 sing N N 113 
CGU OE22 HE22 sing N N 114 
CYS N    CA   sing N N 115 
CYS N    H    sing N N 116 
CYS N    H2   sing N N 117 
CYS CA   C    sing N N 118 
CYS CA   CB   sing N N 119 
CYS CA   HA   sing N N 120 
CYS C    O    doub N N 121 
CYS C    OXT  sing N N 122 
CYS CB   SG   sing N N 123 
CYS CB   HB2  sing N N 124 
CYS CB   HB3  sing N N 125 
CYS SG   HG   sing N N 126 
CYS OXT  HXT  sing N N 127 
FUC C1   C2   sing N N 128 
FUC C1   O1   sing N N 129 
FUC C1   O5   sing N N 130 
FUC C1   H1   sing N N 131 
FUC C2   C3   sing N N 132 
FUC C2   O2   sing N N 133 
FUC C2   H2   sing N N 134 
FUC C3   C4   sing N N 135 
FUC C3   O3   sing N N 136 
FUC C3   H3   sing N N 137 
FUC C4   C5   sing N N 138 
FUC C4   O4   sing N N 139 
FUC C4   H4   sing N N 140 
FUC C5   C6   sing N N 141 
FUC C5   O5   sing N N 142 
FUC C5   H5   sing N N 143 
FUC C6   H61  sing N N 144 
FUC C6   H62  sing N N 145 
FUC C6   H63  sing N N 146 
FUC O1   HO1  sing N N 147 
FUC O2   HO2  sing N N 148 
FUC O3   HO3  sing N N 149 
FUC O4   HO4  sing N N 150 
GLN N    CA   sing N N 151 
GLN N    H    sing N N 152 
GLN N    H2   sing N N 153 
GLN CA   C    sing N N 154 
GLN CA   CB   sing N N 155 
GLN CA   HA   sing N N 156 
GLN C    O    doub N N 157 
GLN C    OXT  sing N N 158 
GLN CB   CG   sing N N 159 
GLN CB   HB2  sing N N 160 
GLN CB   HB3  sing N N 161 
GLN CG   CD   sing N N 162 
GLN CG   HG2  sing N N 163 
GLN CG   HG3  sing N N 164 
GLN CD   OE1  doub N N 165 
GLN CD   NE2  sing N N 166 
GLN NE2  HE21 sing N N 167 
GLN NE2  HE22 sing N N 168 
GLN OXT  HXT  sing N N 169 
GLU N    CA   sing N N 170 
GLU N    H    sing N N 171 
GLU N    H2   sing N N 172 
GLU CA   C    sing N N 173 
GLU CA   CB   sing N N 174 
GLU CA   HA   sing N N 175 
GLU C    O    doub N N 176 
GLU C    OXT  sing N N 177 
GLU CB   CG   sing N N 178 
GLU CB   HB2  sing N N 179 
GLU CB   HB3  sing N N 180 
GLU CG   CD   sing N N 181 
GLU CG   HG2  sing N N 182 
GLU CG   HG3  sing N N 183 
GLU CD   OE1  doub N N 184 
GLU CD   OE2  sing N N 185 
GLU OE2  HE2  sing N N 186 
GLU OXT  HXT  sing N N 187 
GLY N    CA   sing N N 188 
GLY N    H    sing N N 189 
GLY N    H2   sing N N 190 
GLY CA   C    sing N N 191 
GLY CA   HA2  sing N N 192 
GLY CA   HA3  sing N N 193 
GLY C    O    doub N N 194 
GLY C    OXT  sing N N 195 
GLY OXT  HXT  sing N N 196 
HIS N    CA   sing N N 197 
HIS N    H    sing N N 198 
HIS N    H2   sing N N 199 
HIS CA   C    sing N N 200 
HIS CA   CB   sing N N 201 
HIS CA   HA   sing N N 202 
HIS C    O    doub N N 203 
HIS C    OXT  sing N N 204 
HIS CB   CG   sing N N 205 
HIS CB   HB2  sing N N 206 
HIS CB   HB3  sing N N 207 
HIS CG   ND1  sing Y N 208 
HIS CG   CD2  doub Y N 209 
HIS ND1  CE1  doub Y N 210 
HIS ND1  HD1  sing N N 211 
HIS CD2  NE2  sing Y N 212 
HIS CD2  HD2  sing N N 213 
HIS CE1  NE2  sing Y N 214 
HIS CE1  HE1  sing N N 215 
HIS NE2  HE2  sing N N 216 
HIS OXT  HXT  sing N N 217 
HOH O    H1   sing N N 218 
HOH O    H2   sing N N 219 
ILE N    CA   sing N N 220 
ILE N    H    sing N N 221 
ILE N    H2   sing N N 222 
ILE CA   C    sing N N 223 
ILE CA   CB   sing N N 224 
ILE CA   HA   sing N N 225 
ILE C    O    doub N N 226 
ILE C    OXT  sing N N 227 
ILE CB   CG1  sing N N 228 
ILE CB   CG2  sing N N 229 
ILE CB   HB   sing N N 230 
ILE CG1  CD1  sing N N 231 
ILE CG1  HG12 sing N N 232 
ILE CG1  HG13 sing N N 233 
ILE CG2  HG21 sing N N 234 
ILE CG2  HG22 sing N N 235 
ILE CG2  HG23 sing N N 236 
ILE CD1  HD11 sing N N 237 
ILE CD1  HD12 sing N N 238 
ILE CD1  HD13 sing N N 239 
ILE OXT  HXT  sing N N 240 
LEU N    CA   sing N N 241 
LEU N    H    sing N N 242 
LEU N    H2   sing N N 243 
LEU CA   C    sing N N 244 
LEU CA   CB   sing N N 245 
LEU CA   HA   sing N N 246 
LEU C    O    doub N N 247 
LEU C    OXT  sing N N 248 
LEU CB   CG   sing N N 249 
LEU CB   HB2  sing N N 250 
LEU CB   HB3  sing N N 251 
LEU CG   CD1  sing N N 252 
LEU CG   CD2  sing N N 253 
LEU CG   HG   sing N N 254 
LEU CD1  HD11 sing N N 255 
LEU CD1  HD12 sing N N 256 
LEU CD1  HD13 sing N N 257 
LEU CD2  HD21 sing N N 258 
LEU CD2  HD22 sing N N 259 
LEU CD2  HD23 sing N N 260 
LEU OXT  HXT  sing N N 261 
LYS N    CA   sing N N 262 
LYS N    H    sing N N 263 
LYS N    H2   sing N N 264 
LYS CA   C    sing N N 265 
LYS CA   CB   sing N N 266 
LYS CA   HA   sing N N 267 
LYS C    O    doub N N 268 
LYS C    OXT  sing N N 269 
LYS CB   CG   sing N N 270 
LYS CB   HB2  sing N N 271 
LYS CB   HB3  sing N N 272 
LYS CG   CD   sing N N 273 
LYS CG   HG2  sing N N 274 
LYS CG   HG3  sing N N 275 
LYS CD   CE   sing N N 276 
LYS CD   HD2  sing N N 277 
LYS CD   HD3  sing N N 278 
LYS CE   NZ   sing N N 279 
LYS CE   HE2  sing N N 280 
LYS CE   HE3  sing N N 281 
LYS NZ   HZ1  sing N N 282 
LYS NZ   HZ2  sing N N 283 
LYS NZ   HZ3  sing N N 284 
LYS OXT  HXT  sing N N 285 
MET N    CA   sing N N 286 
MET N    H    sing N N 287 
MET N    H2   sing N N 288 
MET CA   C    sing N N 289 
MET CA   CB   sing N N 290 
MET CA   HA   sing N N 291 
MET C    O    doub N N 292 
MET C    OXT  sing N N 293 
MET CB   CG   sing N N 294 
MET CB   HB2  sing N N 295 
MET CB   HB3  sing N N 296 
MET CG   SD   sing N N 297 
MET CG   HG2  sing N N 298 
MET CG   HG3  sing N N 299 
MET SD   CE   sing N N 300 
MET CE   HE1  sing N N 301 
MET CE   HE2  sing N N 302 
MET CE   HE3  sing N N 303 
MET OXT  HXT  sing N N 304 
PHE N    CA   sing N N 305 
PHE N    H    sing N N 306 
PHE N    H2   sing N N 307 
PHE CA   C    sing N N 308 
PHE CA   CB   sing N N 309 
PHE CA   HA   sing N N 310 
PHE C    O    doub N N 311 
PHE C    OXT  sing N N 312 
PHE CB   CG   sing N N 313 
PHE CB   HB2  sing N N 314 
PHE CB   HB3  sing N N 315 
PHE CG   CD1  doub Y N 316 
PHE CG   CD2  sing Y N 317 
PHE CD1  CE1  sing Y N 318 
PHE CD1  HD1  sing N N 319 
PHE CD2  CE2  doub Y N 320 
PHE CD2  HD2  sing N N 321 
PHE CE1  CZ   doub Y N 322 
PHE CE1  HE1  sing N N 323 
PHE CE2  CZ   sing Y N 324 
PHE CE2  HE2  sing N N 325 
PHE CZ   HZ   sing N N 326 
PHE OXT  HXT  sing N N 327 
PRO N    CA   sing N N 328 
PRO N    CD   sing N N 329 
PRO N    H    sing N N 330 
PRO CA   C    sing N N 331 
PRO CA   CB   sing N N 332 
PRO CA   HA   sing N N 333 
PRO C    O    doub N N 334 
PRO C    OXT  sing N N 335 
PRO CB   CG   sing N N 336 
PRO CB   HB2  sing N N 337 
PRO CB   HB3  sing N N 338 
PRO CG   CD   sing N N 339 
PRO CG   HG2  sing N N 340 
PRO CG   HG3  sing N N 341 
PRO CD   HD2  sing N N 342 
PRO CD   HD3  sing N N 343 
PRO OXT  HXT  sing N N 344 
SER N    CA   sing N N 345 
SER N    H    sing N N 346 
SER N    H2   sing N N 347 
SER CA   C    sing N N 348 
SER CA   CB   sing N N 349 
SER CA   HA   sing N N 350 
SER C    O    doub N N 351 
SER C    OXT  sing N N 352 
SER CB   OG   sing N N 353 
SER CB   HB2  sing N N 354 
SER CB   HB3  sing N N 355 
SER OG   HG   sing N N 356 
SER OXT  HXT  sing N N 357 
THR N    CA   sing N N 358 
THR N    H    sing N N 359 
THR N    H2   sing N N 360 
THR CA   C    sing N N 361 
THR CA   CB   sing N N 362 
THR CA   HA   sing N N 363 
THR C    O    doub N N 364 
THR C    OXT  sing N N 365 
THR CB   OG1  sing N N 366 
THR CB   CG2  sing N N 367 
THR CB   HB   sing N N 368 
THR OG1  HG1  sing N N 369 
THR CG2  HG21 sing N N 370 
THR CG2  HG22 sing N N 371 
THR CG2  HG23 sing N N 372 
THR OXT  HXT  sing N N 373 
TRP N    CA   sing N N 374 
TRP N    H    sing N N 375 
TRP N    H2   sing N N 376 
TRP CA   C    sing N N 377 
TRP CA   CB   sing N N 378 
TRP CA   HA   sing N N 379 
TRP C    O    doub N N 380 
TRP C    OXT  sing N N 381 
TRP CB   CG   sing N N 382 
TRP CB   HB2  sing N N 383 
TRP CB   HB3  sing N N 384 
TRP CG   CD1  doub Y N 385 
TRP CG   CD2  sing Y N 386 
TRP CD1  NE1  sing Y N 387 
TRP CD1  HD1  sing N N 388 
TRP CD2  CE2  doub Y N 389 
TRP CD2  CE3  sing Y N 390 
TRP NE1  CE2  sing Y N 391 
TRP NE1  HE1  sing N N 392 
TRP CE2  CZ2  sing Y N 393 
TRP CE3  CZ3  doub Y N 394 
TRP CE3  HE3  sing N N 395 
TRP CZ2  CH2  doub Y N 396 
TRP CZ2  HZ2  sing N N 397 
TRP CZ3  CH2  sing Y N 398 
TRP CZ3  HZ3  sing N N 399 
TRP CH2  HH2  sing N N 400 
TRP OXT  HXT  sing N N 401 
TYR N    CA   sing N N 402 
TYR N    H    sing N N 403 
TYR N    H2   sing N N 404 
TYR CA   C    sing N N 405 
TYR CA   CB   sing N N 406 
TYR CA   HA   sing N N 407 
TYR C    O    doub N N 408 
TYR C    OXT  sing N N 409 
TYR CB   CG   sing N N 410 
TYR CB   HB2  sing N N 411 
TYR CB   HB3  sing N N 412 
TYR CG   CD1  doub Y N 413 
TYR CG   CD2  sing Y N 414 
TYR CD1  CE1  sing Y N 415 
TYR CD1  HD1  sing N N 416 
TYR CD2  CE2  doub Y N 417 
TYR CD2  HD2  sing N N 418 
TYR CE1  CZ   doub Y N 419 
TYR CE1  HE1  sing N N 420 
TYR CE2  CZ   sing Y N 421 
TYR CE2  HE2  sing N N 422 
TYR CZ   OH   sing N N 423 
TYR OH   HH   sing N N 424 
TYR OXT  HXT  sing N N 425 
VAL N    CA   sing N N 426 
VAL N    H    sing N N 427 
VAL N    H2   sing N N 428 
VAL CA   C    sing N N 429 
VAL CA   CB   sing N N 430 
VAL CA   HA   sing N N 431 
VAL C    O    doub N N 432 
VAL C    OXT  sing N N 433 
VAL CB   CG1  sing N N 434 
VAL CB   CG2  sing N N 435 
VAL CB   HB   sing N N 436 
VAL CG1  HG11 sing N N 437 
VAL CG1  HG12 sing N N 438 
VAL CG1  HG13 sing N N 439 
VAL CG2  HG21 sing N N 440 
VAL CG2  HG22 sing N N 441 
VAL CG2  HG23 sing N N 442 
VAL OXT  HXT  sing N N 443 
XGX C18  C17  sing N N 444 
XGX C19  C17  sing N N 445 
XGX N2   C16  sing N N 446 
XGX N2   C15  sing N N 447 
XGX C17  C16  sing N N 448 
XGX C15  O3   doub N N 449 
XGX C15  C11  sing N N 450 
XGX C10  C11  doub Y N 451 
XGX C10  C9   sing Y N 452 
XGX C11  C12  sing Y N 453 
XGX C9   C8   doub Y N 454 
XGX C25  C20  doub Y N 455 
XGX C25  C24  sing Y N 456 
XGX C12  C13  doub Y N 457 
XGX C20  C21  sing Y N 458 
XGX C8   C13  sing Y N 459 
XGX C8   C24  sing N N 460 
XGX O2   C14  doub N N 461 
XGX C13  C14  sing N N 462 
XGX C24  C23  doub Y N 463 
XGX C14  O1   sing N N 464 
XGX C21  C27  sing N N 465 
XGX C21  C22  doub Y N 466 
XGX C27  C26  doub N N 467 
XGX C23  C22  sing Y N 468 
XGX C23  C7   sing N N 469 
XGX C7   O4   doub N N 470 
XGX C7   N1   sing N N 471 
XGX N1   C6   sing N N 472 
XGX C6   C1   doub Y N 473 
XGX C6   C5   sing Y N 474 
XGX C1   C2   sing Y N 475 
XGX C5   C4   doub Y N 476 
XGX C2   C3   doub Y N 477 
XGX C4   C3   sing Y N 478 
XGX C3   C28  sing N N 479 
XGX C28  N4   doub N N 480 
XGX C28  N3   sing N N 481 
XGX C1   H1   sing N N 482 
XGX C2   H2   sing N N 483 
XGX C4   H3   sing N N 484 
XGX C5   H4   sing N N 485 
XGX N1   H5   sing N N 486 
XGX C9   H6   sing N N 487 
XGX C10  H7   sing N N 488 
XGX C12  H8   sing N N 489 
XGX O1   H9   sing N N 490 
XGX N2   H10  sing N N 491 
XGX C16  H11  sing N N 492 
XGX C16  H12  sing N N 493 
XGX C17  H13  sing N N 494 
XGX C18  H14  sing N N 495 
XGX C18  H15  sing N N 496 
XGX C18  H16  sing N N 497 
XGX C19  H17  sing N N 498 
XGX C19  H18  sing N N 499 
XGX C19  H19  sing N N 500 
XGX C20  H20  sing N N 501 
XGX C22  H21  sing N N 502 
XGX C25  H22  sing N N 503 
XGX C26  H23  sing N N 504 
XGX C26  H24  sing N N 505 
XGX C27  H25  sing N N 506 
XGX N3   H26  sing N N 507 
XGX N3   H27  sing N N 508 
XGX N4   H28  sing N N 509 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1dan 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8UUD 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014186 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012067 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007902 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CA 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . ALA A 1 1   ? -8.061  -29.722 25.258  1.00 123.85 ? 1   ALA L N    1 
ATOM   2    C  CA   . ALA A 1 1   ? -9.021  -30.695 25.838  1.00 130.78 ? 1   ALA L CA   1 
ATOM   3    C  C    . ALA A 1 1   ? -9.340  -30.321 27.289  1.00 135.97 ? 1   ALA L C    1 
ATOM   4    O  O    . ALA A 1 1   ? -8.645  -29.501 27.902  1.00 124.61 ? 1   ALA L O    1 
ATOM   5    C  CB   . ALA A 1 1   ? -8.477  -32.103 25.719  1.00 128.12 ? 1   ALA L CB   1 
ATOM   6    N  N    . ASN A 1 2   ? -10.424 -30.911 27.819  1.00 141.55 ? 2   ASN L N    1 
ATOM   7    C  CA   . ASN A 1 2   ? -11.010 -30.471 29.079  1.00 140.47 ? 2   ASN L CA   1 
ATOM   8    C  C    . ASN A 1 2   ? -11.621 -31.668 29.823  1.00 152.15 ? 2   ASN L C    1 
ATOM   9    O  O    . ASN A 1 2   ? -12.717 -32.117 29.483  1.00 141.42 ? 2   ASN L O    1 
ATOM   10   C  CB   . ASN A 1 2   ? -12.054 -29.358 28.865  1.00 132.91 ? 2   ASN L CB   1 
ATOM   11   C  CG   . ASN A 1 2   ? -12.168 -28.813 27.445  1.00 128.65 ? 2   ASN L CG   1 
ATOM   12   O  OD1  . ASN A 1 2   ? -11.345 -28.021 26.964  1.00 131.41 ? 2   ASN L OD1  1 
ATOM   13   N  ND2  . ASN A 1 2   ? -13.242 -29.189 26.770  1.00 113.23 ? 2   ASN L ND2  1 
ATOM   14   N  N    . ALA A 1 3   ? -10.913 -32.163 30.857  1.00 162.04 ? 3   ALA L N    1 
ATOM   15   C  CA   . ALA A 1 3   ? -11.348 -33.298 31.668  1.00 150.38 ? 3   ALA L CA   1 
ATOM   16   C  C    . ALA A 1 3   ? -12.135 -32.838 32.902  1.00 127.66 ? 3   ALA L C    1 
ATOM   17   O  O    . ALA A 1 3   ? -12.331 -31.647 33.128  1.00 114.26 ? 3   ALA L O    1 
ATOM   18   C  CB   . ALA A 1 3   ? -10.142 -34.124 32.067  1.00 150.69 ? 3   ALA L CB   1 
ATOM   19   N  N    . PHE A 1 4   ? -12.610 -33.812 33.688  1.00 118.16 ? 4   PHE L N    1 
ATOM   20   C  CA   . PHE A 1 4   ? -13.253 -33.561 34.971  1.00 119.17 ? 4   PHE L CA   1 
ATOM   21   C  C    . PHE A 1 4   ? -12.307 -32.813 35.918  1.00 111.29 ? 4   PHE L C    1 
ATOM   22   O  O    . PHE A 1 4   ? -11.520 -33.441 36.621  1.00 120.44 ? 4   PHE L O    1 
ATOM   23   C  CB   . PHE A 1 4   ? -13.682 -34.892 35.604  1.00 127.31 ? 4   PHE L CB   1 
ATOM   24   C  CG   . PHE A 1 4   ? -12.543 -35.735 36.132  1.00 134.28 ? 4   PHE L CG   1 
ATOM   25   C  CD1  . PHE A 1 4   ? -12.223 -35.724 37.485  1.00 144.41 ? 4   PHE L CD1  1 
ATOM   26   C  CD2  . PHE A 1 4   ? -11.778 -36.526 35.286  1.00 133.91 ? 4   PHE L CD2  1 
ATOM   27   C  CE1  . PHE A 1 4   ? -11.166 -36.474 37.978  1.00 141.47 ? 4   PHE L CE1  1 
ATOM   28   C  CE2  . PHE A 1 4   ? -10.724 -37.282 35.782  1.00 135.84 ? 4   PHE L CE2  1 
ATOM   29   C  CZ   . PHE A 1 4   ? -10.421 -37.256 37.126  1.00 137.86 ? 4   PHE L CZ   1 
ATOM   30   N  N    . LEU A 1 5   ? -12.419 -31.479 35.979  1.00 88.59  ? 5   LEU L N    1 
ATOM   31   C  CA   . LEU A 1 5   ? -11.369 -30.605 36.504  1.00 94.87  ? 5   LEU L CA   1 
ATOM   32   C  C    . LEU A 1 5   ? -11.337 -29.334 35.642  1.00 106.97 ? 5   LEU L C    1 
ATOM   33   O  O    . LEU A 1 5   ? -12.016 -28.351 36.008  1.00 117.69 ? 5   LEU L O    1 
ATOM   34   C  CB   . LEU A 1 5   ? -9.982  -31.265 36.460  1.00 80.90  ? 5   LEU L CB   1 
ATOM   35   C  CG   . LEU A 1 5   ? -9.313  -31.661 37.775  1.00 90.52  ? 5   LEU L CG   1 
ATOM   36   C  CD1  . LEU A 1 5   ? -10.134 -32.648 38.595  1.00 86.75  ? 5   LEU L CD1  1 
ATOM   37   C  CD2  . LEU A 1 5   ? -7.921  -32.235 37.485  1.00 99.33  ? 5   LEU L CD2  1 
HETATM 38   N  N    . CGU A 1 6   ? -10.685 -29.143 34.390  1.00 81.82  ? 6   CGU L N    1 
HETATM 39   C  CA   . CGU A 1 6   ? -9.237  -29.393 34.169  1.00 80.02  ? 6   CGU L CA   1 
HETATM 40   C  C    . CGU A 1 6   ? -8.466  -28.087 34.377  1.00 78.14  ? 6   CGU L C    1 
HETATM 41   O  O    . CGU A 1 6   ? -8.308  -27.717 35.548  1.00 85.73  ? 6   CGU L O    1 
HETATM 42   C  CB   . CGU A 1 6   ? -9.032  -29.951 32.766  1.00 95.30  ? 6   CGU L CB   1 
HETATM 43   C  CG   . CGU A 1 6   ? -7.679  -29.562 32.168  1.00 115.07 ? 6   CGU L CG   1 
HETATM 44   C  CD1  . CGU A 1 6   ? -7.826  -28.328 31.244  1.00 115.30 ? 6   CGU L CD1  1 
HETATM 45   C  CD2  . CGU A 1 6   ? -7.038  -30.828 31.559  1.00 115.66 ? 6   CGU L CD2  1 
HETATM 46   O  OE11 . CGU A 1 6   ? -8.476  -28.443 30.163  1.00 111.75 ? 6   CGU L OE11 1 
HETATM 47   O  OE12 . CGU A 1 6   ? -7.291  -27.257 31.633  1.00 108.25 ? 6   CGU L OE12 1 
HETATM 48   O  OE21 . CGU A 1 6   ? -7.473  -31.234 30.451  1.00 119.50 ? 6   CGU L OE21 1 
HETATM 49   O  OE22 . CGU A 1 6   ? -6.131  -31.398 32.228  1.00 95.33  ? 6   CGU L OE22 1 
HETATM 50   N  N    . CGU A 1 7   ? -9.662  -27.359 34.159  1.00 87.94  ? 7   CGU L N    1 
HETATM 51   C  CA   . CGU A 1 7   ? -10.456 -26.191 33.682  1.00 111.13 ? 7   CGU L CA   1 
HETATM 52   C  C    . CGU A 1 7   ? -10.750 -25.241 34.852  1.00 100.59 ? 7   CGU L C    1 
HETATM 53   O  O    . CGU A 1 7   ? -10.712 -24.009 34.584  1.00 100.43 ? 7   CGU L O    1 
HETATM 54   C  CB   . CGU A 1 7   ? -11.750 -26.695 33.036  1.00 114.41 ? 7   CGU L CB   1 
HETATM 55   C  CG   . CGU A 1 7   ? -11.710 -26.803 31.507  1.00 117.34 ? 7   CGU L CG   1 
HETATM 56   C  CD1  . CGU A 1 7   ? -11.065 -25.613 30.751  1.00 126.92 ? 7   CGU L CD1  1 
HETATM 57   C  CD2  . CGU A 1 7   ? -13.151 -26.922 30.983  1.00 113.87 ? 7   CGU L CD2  1 
HETATM 58   O  OE11 . CGU A 1 7   ? -9.941  -25.764 30.194  1.00 118.26 ? 7   CGU L OE11 1 
HETATM 59   O  OE12 . CGU A 1 7   ? -11.742 -24.563 30.630  1.00 139.75 ? 7   CGU L OE12 1 
HETATM 60   O  OE21 . CGU A 1 7   ? -13.641 -25.905 30.367  1.00 121.82 ? 7   CGU L OE21 1 
HETATM 61   O  OE22 . CGU A 1 7   ? -13.744 -28.008 31.188  1.00 102.25 ? 7   CGU L OE22 1 
ATOM   62   N  N    . LEU A 1 8   ? -10.775 -25.826 36.169  1.00 75.07  ? 8   LEU L N    1 
ATOM   63   C  CA   . LEU A 1 8   ? -10.190 -25.596 37.526  1.00 66.17  ? 8   LEU L CA   1 
ATOM   64   C  C    . LEU A 1 8   ? -8.878  -24.815 37.419  1.00 65.89  ? 8   LEU L C    1 
ATOM   65   O  O    . LEU A 1 8   ? -8.715  -23.811 38.120  1.00 66.86  ? 8   LEU L O    1 
ATOM   66   C  CB   . LEU A 1 8   ? -9.992  -26.932 38.257  1.00 57.96  ? 8   LEU L CB   1 
ATOM   67   C  CG   . LEU A 1 8   ? -10.837 -27.125 39.520  1.00 51.94  ? 8   LEU L CG   1 
ATOM   68   C  CD1  . LEU A 1 8   ? -12.244 -27.562 39.186  1.00 47.48  ? 8   LEU L CD1  1 
ATOM   69   C  CD2  . LEU A 1 8   ? -10.206 -28.130 40.464  1.00 51.87  ? 8   LEU L CD2  1 
ATOM   70   N  N    . ARG A 1 9   ? -7.955  -25.318 36.571  1.00 63.58  ? 9   ARG L N    1 
ATOM   71   C  CA   . ARG A 1 9   ? -6.737  -24.629 36.162  1.00 60.73  ? 9   ARG L CA   1 
ATOM   72   C  C    . ARG A 1 9   ? -7.111  -23.503 35.212  1.00 59.04  ? 9   ARG L C    1 
ATOM   73   O  O    . ARG A 1 9   ? -7.886  -23.742 34.286  1.00 64.64  ? 9   ARG L O    1 
ATOM   74   C  CB   . ARG A 1 9   ? -5.795  -25.565 35.396  1.00 65.86  ? 9   ARG L CB   1 
ATOM   75   C  CG   . ARG A 1 9   ? -5.286  -26.760 36.189  1.00 68.57  ? 9   ARG L CG   1 
ATOM   76   C  CD   . ARG A 1 9   ? -4.311  -27.639 35.418  1.00 72.30  ? 9   ARG L CD   1 
ATOM   77   N  NE   . ARG A 1 9   ? -4.951  -28.778 34.761  1.00 79.00  ? 9   ARG L NE   1 
ATOM   78   C  CZ   . ARG A 1 9   ? -4.936  -30.035 35.217  1.00 79.40  ? 9   ARG L CZ   1 
ATOM   79   N  NH1  . ARG A 1 9   ? -4.262  -30.334 36.317  1.00 72.30  ? 9   ARG L NH1  1 
ATOM   80   N  NH2  . ARG A 1 9   ? -5.593  -30.993 34.575  1.00 73.07  ? 9   ARG L NH2  1 
ATOM   81   N  N    . PRO A 1 10  ? -6.570  -22.272 35.371  1.00 61.78  ? 10  PRO L N    1 
ATOM   82   C  CA   . PRO A 1 10  ? -7.020  -21.138 34.555  1.00 64.39  ? 10  PRO L CA   1 
ATOM   83   C  C    . PRO A 1 10  ? -6.558  -21.300 33.107  1.00 57.23  ? 10  PRO L C    1 
ATOM   84   O  O    . PRO A 1 10  ? -5.859  -22.264 32.785  1.00 54.91  ? 10  PRO L O    1 
ATOM   85   C  CB   . PRO A 1 10  ? -6.389  -19.918 35.244  1.00 62.54  ? 10  PRO L CB   1 
ATOM   86   C  CG   . PRO A 1 10  ? -5.123  -20.490 35.864  1.00 65.30  ? 10  PRO L CG   1 
ATOM   87   C  CD   . PRO A 1 10  ? -5.475  -21.908 36.283  1.00 61.97  ? 10  PRO L CD   1 
ATOM   88   N  N    . GLY A 1 11  ? -6.965  -20.350 32.257  1.00 54.35  ? 11  GLY L N    1 
ATOM   89   C  CA   . GLY A 1 11  ? -6.635  -20.373 30.842  1.00 58.05  ? 11  GLY L CA   1 
ATOM   90   C  C    . GLY A 1 11  ? -5.127  -20.434 30.612  1.00 56.65  ? 11  GLY L C    1 
ATOM   91   O  O    . GLY A 1 11  ? -4.394  -19.563 31.087  1.00 61.60  ? 11  GLY L O    1 
ATOM   92   N  N    . SER A 1 12  ? -4.700  -21.493 29.910  1.00 48.43  ? 12  SER L N    1 
ATOM   93   C  CA   . SER A 1 12  ? -3.409  -21.549 29.253  1.00 50.09  ? 12  SER L CA   1 
ATOM   94   C  C    . SER A 1 12  ? -3.598  -21.745 27.749  1.00 49.26  ? 12  SER L C    1 
ATOM   95   O  O    . SER A 1 12  ? -4.568  -22.347 27.326  1.00 50.97  ? 12  SER L O    1 
ATOM   96   C  CB   . SER A 1 12  ? -2.595  -22.652 29.852  1.00 52.08  ? 12  SER L CB   1 
ATOM   97   O  OG   . SER A 1 12  ? -1.305  -22.716 29.265  1.00 48.37  ? 12  SER L OG   1 
ATOM   98   N  N    . LEU A 1 13  ? -2.665  -21.228 26.942  1.00 60.53  ? 13  LEU L N    1 
ATOM   99   C  CA   . LEU A 1 13  ? -2.546  -21.571 25.532  1.00 55.97  ? 13  LEU L CA   1 
ATOM   100  C  C    . LEU A 1 13  ? -1.490  -22.679 25.378  1.00 61.68  ? 13  LEU L C    1 
ATOM   101  O  O    . LEU A 1 13  ? -1.876  -23.852 25.468  1.00 64.41  ? 13  LEU L O    1 
ATOM   102  C  CB   . LEU A 1 13  ? -2.147  -20.290 24.791  1.00 54.70  ? 13  LEU L CB   1 
ATOM   103  C  CG   . LEU A 1 13  ? -2.296  -20.293 23.266  1.00 56.19  ? 13  LEU L CG   1 
ATOM   104  C  CD1  . LEU A 1 13  ? -3.723  -19.989 22.833  1.00 55.51  ? 13  LEU L CD1  1 
ATOM   105  C  CD2  . LEU A 1 13  ? -1.341  -19.296 22.626  1.00 55.52  ? 13  LEU L CD2  1 
HETATM 106  N  N    . CGU A 1 14  ? -0.613  -23.544 26.131  1.00 74.67  ? 14  CGU L N    1 
HETATM 107  C  CA   . CGU A 1 14  ? 0.375   -24.596 26.513  1.00 95.92  ? 14  CGU L CA   1 
HETATM 108  C  C    . CGU A 1 14  ? -0.288  -25.968 26.311  1.00 105.93 ? 14  CGU L C    1 
HETATM 109  O  O    . CGU A 1 14  ? -1.150  -26.045 25.400  1.00 94.01  ? 14  CGU L O    1 
HETATM 110  C  CB   . CGU A 1 14  ? 0.813   -24.401 27.975  1.00 108.83 ? 14  CGU L CB   1 
HETATM 111  C  CG   . CGU A 1 14  ? 2.280   -24.158 28.362  1.00 105.85 ? 14  CGU L CG   1 
HETATM 112  C  CD1  . CGU A 1 14  ? 2.880   -25.381 29.094  1.00 102.62 ? 14  CGU L CD1  1 
HETATM 113  C  CD2  . CGU A 1 14  ? 3.120   -23.704 27.152  1.00 101.76 ? 14  CGU L CD2  1 
HETATM 114  O  OE11 . CGU A 1 14  ? 3.757   -26.042 28.508  1.00 89.84  ? 14  CGU L OE11 1 
HETATM 115  O  OE12 . CGU A 1 14  ? 2.467   -25.640 30.259  1.00 95.71  ? 14  CGU L OE12 1 
HETATM 116  O  OE21 . CGU A 1 14  ? 3.068   -24.393 26.108  1.00 95.89  ? 14  CGU L OE21 1 
HETATM 117  O  OE22 . CGU A 1 14  ? 3.799   -22.660 27.279  1.00 103.78 ? 14  CGU L OE22 1 
ATOM   118  N  N    . ARG A 1 15  ? -0.440  -27.177 27.089  1.00 129.79 ? 15  ARG L N    1 
ATOM   119  C  CA   . ARG A 1 15  ? -1.383  -27.663 28.136  1.00 132.04 ? 15  ARG L CA   1 
ATOM   120  C  C    . ARG A 1 15  ? -2.636  -26.771 28.062  1.00 111.55 ? 15  ARG L C    1 
ATOM   121  O  O    . ARG A 1 15  ? -2.525  -25.598 28.490  1.00 110.28 ? 15  ARG L O    1 
ATOM   122  C  CB   . ARG A 1 15  ? -0.639  -27.804 29.484  1.00 133.16 ? 15  ARG L CB   1 
ATOM   123  C  CG   . ARG A 1 15  ? -1.310  -27.236 30.735  1.00 136.70 ? 15  ARG L CG   1 
ATOM   124  C  CD   . ARG A 1 15  ? -0.563  -26.043 31.325  1.00 137.80 ? 15  ARG L CD   1 
ATOM   125  N  NE   . ARG A 1 15  ? -1.448  -25.007 31.850  1.00 140.17 ? 15  ARG L NE   1 
ATOM   126  C  CZ   . ARG A 1 15  ? -2.018  -24.982 33.052  1.00 132.46 ? 15  ARG L CZ   1 
ATOM   127  N  NH1  . ARG A 1 15  ? -3.028  -24.158 33.273  1.00 122.72 ? 15  ARG L NH1  1 
ATOM   128  N  NH2  . ARG A 1 15  ? -1.619  -25.798 34.015  1.00 137.75 ? 15  ARG L NH2  1 
HETATM 129  N  N    . CGU A 1 16  ? -3.311  -26.587 26.782  1.00 73.56  ? 16  CGU L N    1 
HETATM 130  C  CA   . CGU A 1 16  ? -4.727  -26.261 26.432  1.00 67.04  ? 16  CGU L CA   1 
HETATM 131  C  C    . CGU A 1 16  ? -4.931  -25.977 24.930  1.00 73.35  ? 16  CGU L C    1 
HETATM 132  O  O    . CGU A 1 16  ? -6.119  -26.136 24.483  1.00 58.97  ? 16  CGU L O    1 
HETATM 133  C  CB   . CGU A 1 16  ? -5.147  -25.025 27.221  1.00 75.45  ? 16  CGU L CB   1 
HETATM 134  C  CG   . CGU A 1 16  ? -6.036  -25.196 28.457  1.00 84.01  ? 16  CGU L CG   1 
HETATM 135  C  CD1  . CGU A 1 16  ? -6.301  -26.678 28.808  1.00 93.94  ? 16  CGU L CD1  1 
HETATM 136  C  CD2  . CGU A 1 16  ? -7.359  -24.427 28.233  1.00 67.90  ? 16  CGU L CD2  1 
HETATM 137  O  OE11 . CGU A 1 16  ? -7.076  -27.297 28.073  1.00 113.14 ? 16  CGU L OE11 1 
HETATM 138  O  OE12 . CGU A 1 16  ? -5.732  -27.200 29.809  1.00 102.88 ? 16  CGU L OE12 1 
HETATM 139  O  OE21 . CGU A 1 16  ? -7.349  -23.185 28.017  1.00 50.05  ? 16  CGU L OE21 1 
HETATM 140  O  OE22 . CGU A 1 16  ? -8.375  -25.085 28.292  1.00 72.80  ? 16  CGU L OE22 1 
ATOM   141  N  N    . CYS A 1 17  ? -4.405  -25.007 23.960  1.00 63.24  ? 17  CYS L N    1 
ATOM   142  C  CA   . CYS A 1 17  ? -4.600  -25.081 22.483  1.00 54.12  ? 17  CYS L CA   1 
ATOM   143  C  C    . CYS A 1 17  ? -3.479  -25.871 21.797  1.00 56.80  ? 17  CYS L C    1 
ATOM   144  O  O    . CYS A 1 17  ? -3.714  -26.408 20.718  1.00 47.84  ? 17  CYS L O    1 
ATOM   145  C  CB   . CYS A 1 17  ? -4.741  -23.698 21.863  1.00 47.43  ? 17  CYS L CB   1 
ATOM   146  S  SG   . CYS A 1 17  ? -6.276  -22.838 22.306  1.00 39.75  ? 17  CYS L SG   1 
ATOM   147  N  N    . LYS A 1 18  ? -2.285  -25.963 22.412  1.00 67.90  ? 18  LYS L N    1 
ATOM   148  C  CA   . LYS A 1 18  ? -1.213  -26.810 21.895  1.00 78.93  ? 18  LYS L CA   1 
ATOM   149  C  C    . LYS A 1 18  ? -0.824  -27.881 22.931  1.00 80.66  ? 18  LYS L C    1 
ATOM   150  O  O    . LYS A 1 18  ? -1.741  -28.412 23.596  1.00 75.39  ? 18  LYS L O    1 
ATOM   151  C  CB   . LYS A 1 18  ? -0.014  -25.941 21.494  1.00 94.76  ? 18  LYS L CB   1 
ATOM   152  C  CG   . LYS A 1 18  ? 1.067   -26.655 20.681  1.00 117.55 ? 18  LYS L CG   1 
ATOM   153  C  CD   . LYS A 1 18  ? 2.151   -25.743 20.088  1.00 129.04 ? 18  LYS L CD   1 
ATOM   154  C  CE   . LYS A 1 18  ? 3.302   -25.431 21.026  1.00 132.38 ? 18  LYS L CE   1 
ATOM   155  N  NZ   . LYS A 1 18  ? 2.879   -24.627 22.198  1.00 136.29 ? 18  LYS L NZ   1 
HETATM 156  N  N    . CGU A 1 19  ? -0.404  -28.811 23.959  1.00 98.67  ? 19  CGU L N    1 
HETATM 157  C  CA   . CGU A 1 19  ? 0.142   -30.153 24.319  1.00 109.36 ? 19  CGU L CA   1 
HETATM 158  C  C    . CGU A 1 19  ? -0.947  -31.209 24.081  1.00 111.07 ? 19  CGU L C    1 
HETATM 159  O  O    . CGU A 1 19  ? -0.541  -32.391 23.956  1.00 105.46 ? 19  CGU L O    1 
HETATM 160  C  CB   . CGU A 1 19  ? 0.612   -30.183 25.779  1.00 103.36 ? 19  CGU L CB   1 
HETATM 161  C  CG   . CGU A 1 19  ? 1.797   -29.271 26.104  1.00 107.36 ? 19  CGU L CG   1 
HETATM 162  C  CD1  . CGU A 1 19  ? 3.138   -29.765 25.524  1.00 107.77 ? 19  CGU L CD1  1 
HETATM 163  C  CD2  . CGU A 1 19  ? 1.975   -29.101 27.625  1.00 105.08 ? 19  CGU L CD2  1 
HETATM 164  O  OE11 . CGU A 1 19  ? 3.271   -30.987 25.303  1.00 115.71 ? 19  CGU L OE11 1 
HETATM 165  O  OE12 . CGU A 1 19  ? 4.034   -28.910 25.334  1.00 87.48  ? 19  CGU L OE12 1 
HETATM 166  O  OE21 . CGU A 1 19  ? 2.200   -27.958 28.057  1.00 88.89  ? 19  CGU L OE21 1 
HETATM 167  O  OE22 . CGU A 1 19  ? 1.911   -30.116 28.335  1.00 118.80 ? 19  CGU L OE22 1 
HETATM 168  N  N    . CGU A 1 20  ? -2.319  -30.760 23.901  1.00 86.99  ? 20  CGU L N    1 
HETATM 169  C  CA   . CGU A 1 20  ? -3.748  -30.942 23.500  1.00 91.10  ? 20  CGU L CA   1 
HETATM 170  C  C    . CGU A 1 20  ? -4.175  -29.905 22.448  1.00 87.59  ? 20  CGU L C    1 
HETATM 171  O  O    . CGU A 1 20  ? -4.167  -28.699 22.807  1.00 81.87  ? 20  CGU L O    1 
HETATM 172  C  CB   . CGU A 1 20  ? -4.683  -30.774 24.696  1.00 102.47 ? 20  CGU L CB   1 
HETATM 173  C  CG   . CGU A 1 20  ? -4.401  -31.512 25.999  1.00 114.49 ? 20  CGU L CG   1 
HETATM 174  C  CD1  . CGU A 1 20  ? -4.853  -32.986 25.949  1.00 111.93 ? 20  CGU L CD1  1 
HETATM 175  C  CD2  . CGU A 1 20  ? -5.139  -30.759 27.125  1.00 115.33 ? 20  CGU L CD2  1 
HETATM 176  O  OE11 . CGU A 1 20  ? -5.540  -33.367 24.973  1.00 102.91 ? 20  CGU L OE11 1 
HETATM 177  O  OE12 . CGU A 1 20  ? -4.530  -33.715 26.912  1.00 105.52 ? 20  CGU L OE12 1 
HETATM 178  O  OE21 . CGU A 1 20  ? -6.351  -30.516 26.948  1.00 99.37  ? 20  CGU L OE21 1 
HETATM 179  O  OE22 . CGU A 1 20  ? -4.500  -30.421 28.149  1.00 112.14 ? 20  CGU L OE22 1 
ATOM   180  N  N    . GLN A 1 21  ? -5.554  -29.672 22.036  1.00 69.59  ? 21  GLN L N    1 
ATOM   181  C  CA   . GLN A 1 21  ? -6.124  -29.077 20.791  1.00 74.65  ? 21  GLN L CA   1 
ATOM   182  C  C    . GLN A 1 21  ? -7.516  -28.485 21.024  1.00 67.46  ? 21  GLN L C    1 
ATOM   183  O  O    . GLN A 1 21  ? -8.445  -29.221 21.331  1.00 80.16  ? 21  GLN L O    1 
ATOM   184  C  CB   . GLN A 1 21  ? -6.194  -30.138 19.689  1.00 88.16  ? 21  GLN L CB   1 
ATOM   185  C  CG   . GLN A 1 21  ? -4.824  -30.594 19.187  1.00 94.90  ? 21  GLN L CG   1 
ATOM   186  C  CD   . GLN A 1 21  ? -3.908  -29.445 18.825  1.00 101.97 ? 21  GLN L CD   1 
ATOM   187  O  OE1  . GLN A 1 21  ? -2.848  -29.256 19.420  1.00 95.75  ? 21  GLN L OE1  1 
ATOM   188  N  NE2  . GLN A 1 21  ? -4.317  -28.651 17.846  1.00 105.47 ? 21  GLN L NE2  1 
ATOM   189  N  N    . CYS A 1 22  ? -7.682  -27.175 20.767  1.00 59.28  ? 22  CYS L N    1 
ATOM   190  C  CA   . CYS A 1 22  ? -8.747  -26.393 21.392  1.00 54.65  ? 22  CYS L CA   1 
ATOM   191  C  C    . CYS A 1 22  ? -9.822  -25.923 20.421  1.00 55.31  ? 22  CYS L C    1 
ATOM   192  O  O    . CYS A 1 22  ? -9.619  -25.760 19.220  1.00 53.80  ? 22  CYS L O    1 
ATOM   193  C  CB   . CYS A 1 22  ? -8.255  -25.152 22.147  1.00 52.87  ? 22  CYS L CB   1 
ATOM   194  S  SG   . CYS A 1 22  ? -7.771  -23.688 21.174  1.00 45.26  ? 22  CYS L SG   1 
ATOM   195  N  N    . SER A 1 23  ? -10.986 -25.677 21.021  1.00 59.00  ? 23  SER L N    1 
ATOM   196  C  CA   . SER A 1 23  ? -12.126 -25.106 20.337  1.00 55.11  ? 23  SER L CA   1 
ATOM   197  C  C    . SER A 1 23  ? -11.971 -23.595 20.251  1.00 56.59  ? 23  SER L C    1 
ATOM   198  O  O    . SER A 1 23  ? -11.232 -22.979 21.018  1.00 59.66  ? 23  SER L O    1 
ATOM   199  C  CB   . SER A 1 23  ? -13.396 -25.452 21.057  1.00 56.23  ? 23  SER L CB   1 
ATOM   200  O  OG   . SER A 1 23  ? -14.420 -24.534 20.708  1.00 47.64  ? 23  SER L OG   1 
ATOM   201  N  N    . PHE A 1 24  ? -12.752 -22.999 19.355  1.00 50.79  ? 24  PHE L N    1 
ATOM   202  C  CA   . PHE A 1 24  ? -12.713 -21.565 19.136  1.00 52.67  ? 24  PHE L CA   1 
ATOM   203  C  C    . PHE A 1 24  ? -12.912 -20.769 20.437  1.00 64.77  ? 24  PHE L C    1 
ATOM   204  O  O    . PHE A 1 24  ? -12.974 -19.509 20.342  1.00 54.57  ? 24  PHE L O    1 
ATOM   205  C  CB   . PHE A 1 24  ? -13.813 -21.182 18.153  1.00 50.28  ? 24  PHE L CB   1 
ATOM   206  C  CG   . PHE A 1 24  ? -13.711 -19.763 17.671  1.00 49.23  ? 24  PHE L CG   1 
ATOM   207  C  CD1  . PHE A 1 24  ? -12.710 -19.400 16.797  1.00 51.00  ? 24  PHE L CD1  1 
ATOM   208  C  CD2  . PHE A 1 24  ? -14.580 -18.783 18.115  1.00 51.47  ? 24  PHE L CD2  1 
ATOM   209  C  CE1  . PHE A 1 24  ? -12.598 -18.094 16.344  1.00 50.04  ? 24  PHE L CE1  1 
ATOM   210  C  CE2  . PHE A 1 24  ? -14.450 -17.469 17.684  1.00 51.28  ? 24  PHE L CE2  1 
ATOM   211  C  CZ   . PHE A 1 24  ? -13.461 -17.129 16.794  1.00 48.45  ? 24  PHE L CZ   1 
HETATM 212  N  N    . CGU A 1 25  ? -14.019 -20.863 21.360  1.00 69.13  ? 25  CGU L N    1 
HETATM 213  C  CA   . CGU A 1 25  ? -14.090 -20.301 22.738  1.00 63.51  ? 25  CGU L CA   1 
HETATM 214  C  C    . CGU A 1 25  ? -12.931 -20.879 23.563  1.00 60.45  ? 25  CGU L C    1 
HETATM 215  O  O    . CGU A 1 25  ? -12.204 -20.000 24.035  1.00 58.57  ? 25  CGU L O    1 
HETATM 216  C  CB   . CGU A 1 25  ? -15.443 -20.650 23.368  1.00 77.44  ? 25  CGU L CB   1 
HETATM 217  C  CG   . CGU A 1 25  ? -16.553 -19.587 23.418  1.00 76.48  ? 25  CGU L CG   1 
HETATM 218  C  CD1  . CGU A 1 25  ? -17.716 -20.038 24.318  1.00 75.38  ? 25  CGU L CD1  1 
HETATM 219  C  CD2  . CGU A 1 25  ? -16.233 -18.240 24.098  1.00 74.74  ? 25  CGU L CD2  1 
HETATM 220  O  OE11 . CGU A 1 25  ? -18.631 -20.708 23.808  1.00 61.13  ? 25  CGU L OE11 1 
HETATM 221  O  OE12 . CGU A 1 25  ? -17.651 -19.702 25.537  1.00 88.07  ? 25  CGU L OE12 1 
HETATM 222  O  OE21 . CGU A 1 25  ? -16.250 -17.236 23.370  1.00 49.77  ? 25  CGU L OE21 1 
HETATM 223  O  OE22 . CGU A 1 25  ? -16.073 -18.221 25.377  1.00 77.14  ? 25  CGU L OE22 1 
HETATM 224  N  N    . CGU A 1 26  ? -12.292 -22.094 24.113  1.00 63.98  ? 26  CGU L N    1 
HETATM 225  C  CA   . CGU A 1 26  ? -11.027 -22.269 24.896  1.00 72.59  ? 26  CGU L CA   1 
HETATM 226  C  C    . CGU A 1 26  ? -10.043 -21.174 24.427  1.00 71.29  ? 26  CGU L C    1 
HETATM 227  O  O    . CGU A 1 26  ? -9.909  -20.135 25.140  1.00 67.61  ? 26  CGU L O    1 
HETATM 228  C  CB   . CGU A 1 26  ? -10.446 -23.693 24.713  1.00 70.41  ? 26  CGU L CB   1 
HETATM 229  C  CG   . CGU A 1 26  ? -10.228 -24.650 25.904  1.00 71.76  ? 26  CGU L CG   1 
HETATM 230  C  CD1  . CGU A 1 26  ? -11.379 -24.705 26.915  1.00 67.46  ? 26  CGU L CD1  1 
HETATM 231  C  CD2  . CGU A 1 26  ? -10.045 -26.165 25.599  1.00 84.85  ? 26  CGU L CD2  1 
HETATM 232  O  OE11 . CGU A 1 26  ? -12.394 -23.958 26.750  1.00 68.51  ? 26  CGU L OE11 1 
HETATM 233  O  OE12 . CGU A 1 26  ? -11.230 -25.557 27.829  1.00 69.43  ? 26  CGU L OE12 1 
HETATM 234  O  OE21 . CGU A 1 26  ? -9.138  -26.527 24.803  1.00 75.48  ? 26  CGU L OE21 1 
HETATM 235  O  OE22 . CGU A 1 26  ? -10.782 -27.005 26.248  1.00 114.14 ? 26  CGU L OE22 1 
ATOM   236  N  N    . ALA A 1 27  ? -9.897  -20.341 23.268  1.00 59.34  ? 27  ALA L N    1 
ATOM   237  C  CA   . ALA A 1 27  ? -9.232  -19.377 22.357  1.00 58.18  ? 27  ALA L CA   1 
ATOM   238  C  C    . ALA A 1 27  ? -9.703  -17.945 22.605  1.00 57.31  ? 27  ALA L C    1 
ATOM   239  O  O    . ALA A 1 27  ? -9.060  -17.005 22.182  1.00 52.55  ? 27  ALA L O    1 
ATOM   240  C  CB   . ALA A 1 27  ? -9.463  -19.786 20.928  1.00 60.27  ? 27  ALA L CB   1 
ATOM   241  N  N    . ARG A 1 28  ? -10.810 -17.752 23.320  1.00 74.24  ? 28  ARG L N    1 
ATOM   242  C  CA   . ARG A 1 28  ? -11.220 -16.409 23.683  1.00 63.83  ? 28  ARG L CA   1 
ATOM   243  C  C    . ARG A 1 28  ? -11.892 -16.434 25.061  1.00 63.26  ? 28  ARG L C    1 
ATOM   244  O  O    . ARG A 1 28  ? -11.355 -15.718 25.924  1.00 61.57  ? 28  ARG L O    1 
ATOM   245  C  CB   . ARG A 1 28  ? -12.113 -15.890 22.563  1.00 64.05  ? 28  ARG L CB   1 
ATOM   246  C  CG   . ARG A 1 28  ? -12.244 -14.377 22.542  1.00 70.97  ? 28  ARG L CG   1 
ATOM   247  C  CD   . ARG A 1 28  ? -13.303 -13.916 21.543  1.00 66.40  ? 28  ARG L CD   1 
ATOM   248  N  NE   . ARG A 1 28  ? -14.611 -14.499 21.823  1.00 63.05  ? 28  ARG L NE   1 
ATOM   249  C  CZ   . ARG A 1 28  ? -15.285 -14.348 22.964  1.00 61.21  ? 28  ARG L CZ   1 
ATOM   250  N  NH1  . ARG A 1 28  ? -15.027 -13.340 23.782  1.00 48.27  ? 28  ARG L NH1  1 
ATOM   251  N  NH2  . ARG A 1 28  ? -16.243 -15.206 23.270  1.00 70.37  ? 28  ARG L NH2  1 
HETATM 252  N  N    . CGU A 1 29  ? -11.970 -17.296 26.221  1.00 84.55  ? 29  CGU L N    1 
HETATM 253  C  CA   . CGU A 1 29  ? -11.334 -17.709 27.516  1.00 111.12 ? 29  CGU L CA   1 
HETATM 254  C  C    . CGU A 1 29  ? -9.884  -17.185 27.556  1.00 100.30 ? 29  CGU L C    1 
HETATM 255  O  O    . CGU A 1 29  ? -9.287  -17.262 28.671  1.00 116.18 ? 29  CGU L O    1 
HETATM 256  C  CB   . CGU A 1 29  ? -11.399 -19.241 27.730  1.00 106.97 ? 29  CGU L CB   1 
HETATM 257  C  CG   . CGU A 1 29  ? -12.743 -19.897 27.382  1.00 98.68  ? 29  CGU L CG   1 
HETATM 258  C  CD1  . CGU A 1 29  ? -13.854 -18.936 27.850  1.00 80.40  ? 29  CGU L CD1  1 
HETATM 259  C  CD2  . CGU A 1 29  ? -12.948 -21.344 27.911  1.00 97.93  ? 29  CGU L CD2  1 
HETATM 260  O  OE11 . CGU A 1 29  ? -14.325 -18.118 27.002  1.00 56.88  ? 29  CGU L OE11 1 
HETATM 261  O  OE12 . CGU A 1 29  ? -14.169 -18.983 29.063  1.00 76.77  ? 29  CGU L OE12 1 
HETATM 262  O  OE21 . CGU A 1 29  ? -14.117 -21.828 27.815  1.00 87.59  ? 29  CGU L OE21 1 
HETATM 263  O  OE22 . CGU A 1 29  ? -11.945 -22.002 28.360  1.00 110.09 ? 29  CGU L OE22 1 
ATOM   264  N  N    . ILE A 1 30  ? -9.168  -16.535 26.475  1.00 52.71  ? 30  ILE L N    1 
ATOM   265  C  CA   . ILE A 1 30  ? -7.679  -16.420 26.462  1.00 48.43  ? 30  ILE L CA   1 
ATOM   266  C  C    . ILE A 1 30  ? -7.298  -15.082 25.824  1.00 46.39  ? 30  ILE L C    1 
ATOM   267  O  O    . ILE A 1 30  ? -6.734  -14.222 26.488  1.00 45.87  ? 30  ILE L O    1 
ATOM   268  C  CB   . ILE A 1 30  ? -7.001  -17.616 25.763  1.00 49.33  ? 30  ILE L CB   1 
ATOM   269  C  CG1  . ILE A 1 30  ? -7.109  -18.898 26.594  1.00 50.51  ? 30  ILE L CG1  1 
ATOM   270  C  CG2  . ILE A 1 30  ? -5.547  -17.271 25.432  1.00 46.71  ? 30  ILE L CG2  1 
ATOM   271  C  CD1  . ILE A 1 30  ? -6.578  -20.139 25.911  1.00 53.92  ? 30  ILE L CD1  1 
ATOM   272  N  N    . PHE A 1 31  ? -7.600  -14.898 24.538  1.00 41.67  ? 31  PHE L N    1 
ATOM   273  C  CA   . PHE A 1 31  ? -7.169  -13.698 23.831  1.00 41.82  ? 31  PHE L CA   1 
ATOM   274  C  C    . PHE A 1 31  ? -8.061  -12.495 24.128  1.00 49.16  ? 31  PHE L C    1 
ATOM   275  O  O    . PHE A 1 31  ? -7.596  -11.374 23.966  1.00 52.89  ? 31  PHE L O    1 
ATOM   276  C  CB   . PHE A 1 31  ? -7.097  -13.926 22.317  1.00 41.19  ? 31  PHE L CB   1 
ATOM   277  C  CG   . PHE A 1 31  ? -5.851  -14.654 21.910  1.00 40.28  ? 31  PHE L CG   1 
ATOM   278  C  CD1  . PHE A 1 31  ? -4.624  -14.031 22.026  1.00 39.76  ? 31  PHE L CD1  1 
ATOM   279  C  CD2  . PHE A 1 31  ? -5.885  -15.984 21.522  1.00 42.73  ? 31  PHE L CD2  1 
ATOM   280  C  CE1  . PHE A 1 31  ? -3.460  -14.708 21.713  1.00 39.94  ? 31  PHE L CE1  1 
ATOM   281  C  CE2  . PHE A 1 31  ? -4.713  -16.660 21.211  1.00 40.72  ? 31  PHE L CE2  1 
ATOM   282  C  CZ   . PHE A 1 31  ? -3.509  -16.013 21.294  1.00 37.97  ? 31  PHE L CZ   1 
ATOM   283  N  N    . LYS A 1 32  ? -9.326  -12.720 24.525  1.00 55.96  ? 32  LYS L N    1 
ATOM   284  C  CA   . LYS A 1 32  ? -10.271 -11.664 24.886  1.00 55.79  ? 32  LYS L CA   1 
ATOM   285  C  C    . LYS A 1 32  ? -10.607 -10.809 23.658  1.00 53.39  ? 32  LYS L C    1 
ATOM   286  O  O    . LYS A 1 32  ? -11.723 -10.852 23.160  1.00 54.35  ? 32  LYS L O    1 
ATOM   287  C  CB   . LYS A 1 32  ? -9.801  -10.784 26.057  1.00 57.73  ? 32  LYS L CB   1 
ATOM   288  C  CG   . LYS A 1 32  ? -9.810  -11.409 27.457  1.00 71.46  ? 32  LYS L CG   1 
ATOM   289  C  CD   . LYS A 1 32  ? -8.448  -11.837 28.029  1.00 92.17  ? 32  LYS L CD   1 
ATOM   290  C  CE   . LYS A 1 32  ? -7.317  -10.839 27.836  1.00 109.63 ? 32  LYS L CE   1 
ATOM   291  N  NZ   . LYS A 1 32  ? -7.643  -9.493  28.370  1.00 114.66 ? 32  LYS L NZ   1 
ATOM   292  N  N    . ASP A 1 33  ? -9.663  -10.010 23.156  1.00 55.67  ? 33  ASP L N    1 
ATOM   293  C  CA   . ASP A 1 33  ? -9.932  -9.205  21.970  1.00 54.10  ? 33  ASP L CA   1 
ATOM   294  C  C    . ASP A 1 33  ? -10.018 -10.105 20.740  1.00 51.68  ? 33  ASP L C    1 
ATOM   295  O  O    . ASP A 1 33  ? -9.282  -11.082 20.602  1.00 49.50  ? 33  ASP L O    1 
ATOM   296  C  CB   . ASP A 1 33  ? -8.896  -8.091  21.758  1.00 56.86  ? 33  ASP L CB   1 
ATOM   297  C  CG   . ASP A 1 33  ? -8.841  -7.477  20.359  1.00 53.50  ? 33  ASP L CG   1 
ATOM   298  O  OD1  . ASP A 1 33  ? -9.898  -7.152  19.795  1.00 52.57  ? 33  ASP L OD1  1 
ATOM   299  O  OD2  . ASP A 1 33  ? -7.734  -7.291  19.855  1.00 50.93  ? 33  ASP L OD2  1 
ATOM   300  N  N    . ALA A 1 34  ? -10.913 -9.723  19.827  1.00 50.06  ? 34  ALA L N    1 
ATOM   301  C  CA   . ALA A 1 34  ? -11.168 -10.497 18.632  1.00 55.61  ? 34  ALA L CA   1 
ATOM   302  C  C    . ALA A 1 34  ? -10.630 -9.772  17.386  1.00 65.71  ? 34  ALA L C    1 
ATOM   303  O  O    . ALA A 1 34  ? -10.628 -10.479 16.365  1.00 55.80  ? 34  ALA L O    1 
ATOM   304  C  CB   . ALA A 1 34  ? -12.643 -10.774 18.548  1.00 51.91  ? 34  ALA L CB   1 
HETATM 305  N  N    . CGU A 1 35  ? -9.687  -8.819  16.766  1.00 87.05  ? 35  CGU L N    1 
HETATM 306  C  CA   . CGU A 1 35  ? -8.883  -8.960  15.509  1.00 98.16  ? 35  CGU L CA   1 
HETATM 307  C  C    . CGU A 1 35  ? -8.073  -10.262 15.589  1.00 84.32  ? 35  CGU L C    1 
HETATM 308  O  O    . CGU A 1 35  ? -7.758  -10.775 14.482  1.00 90.37  ? 35  CGU L O    1 
HETATM 309  C  CB   . CGU A 1 35  ? -7.895  -7.810  15.239  1.00 108.96 ? 35  CGU L CB   1 
HETATM 310  C  CG   . CGU A 1 35  ? -8.244  -6.325  15.376  1.00 118.65 ? 35  CGU L CG   1 
HETATM 311  C  CD1  . CGU A 1 35  ? -9.772  -6.120  15.450  1.00 108.18 ? 35  CGU L CD1  1 
HETATM 312  C  CD2  . CGU A 1 35  ? -7.371  -5.738  16.512  1.00 132.80 ? 35  CGU L CD2  1 
HETATM 313  O  OE11 . CGU A 1 35  ? -10.461 -6.613  14.532  1.00 93.68  ? 35  CGU L OE11 1 
HETATM 314  O  OE12 . CGU A 1 35  ? -10.245 -5.456  16.397  1.00 99.41  ? 35  CGU L OE12 1 
HETATM 315  O  OE21 . CGU A 1 35  ? -6.667  -4.739  16.242  1.00 133.01 ? 35  CGU L OE21 1 
HETATM 316  O  OE22 . CGU A 1 35  ? -7.364  -6.317  17.622  1.00 126.67 ? 35  CGU L OE22 1 
ATOM   317  N  N    . ARG A 1 36  ? -7.320  -10.315 16.830  1.00 53.55  ? 36  ARG L N    1 
ATOM   318  C  CA   . ARG A 1 36  ? -6.426  -11.030 17.782  1.00 46.63  ? 36  ARG L CA   1 
ATOM   319  C  C    . ARG A 1 36  ? -6.808  -12.498 17.872  1.00 42.36  ? 36  ARG L C    1 
ATOM   320  O  O    . ARG A 1 36  ? -5.944  -13.362 17.837  1.00 38.65  ? 36  ARG L O    1 
ATOM   321  C  CB   . ARG A 1 36  ? -6.516  -10.454 19.193  1.00 48.14  ? 36  ARG L CB   1 
ATOM   322  C  CG   . ARG A 1 36  ? -5.437  -9.442  19.534  1.00 50.55  ? 36  ARG L CG   1 
ATOM   323  C  CD   . ARG A 1 36  ? -5.394  -9.140  21.026  1.00 49.02  ? 36  ARG L CD   1 
ATOM   324  N  NE   . ARG A 1 36  ? -4.681  -7.902  21.317  1.00 46.67  ? 36  ARG L NE   1 
ATOM   325  C  CZ   . ARG A 1 36  ? -4.563  -7.348  22.522  1.00 52.82  ? 36  ARG L CZ   1 
ATOM   326  N  NH1  . ARG A 1 36  ? -5.144  -7.899  23.571  1.00 57.67  ? 36  ARG L NH1  1 
ATOM   327  N  NH2  . ARG A 1 36  ? -3.867  -6.233  22.678  1.00 52.86  ? 36  ARG L NH2  1 
ATOM   328  N  N    . THR A 1 37  ? -8.102  -12.763 18.072  1.00 44.42  ? 37  THR L N    1 
ATOM   329  C  CA   . THR A 1 37  ? -8.586  -14.132 18.093  1.00 45.13  ? 37  THR L CA   1 
ATOM   330  C  C    . THR A 1 37  ? -8.618  -14.679 16.663  1.00 43.44  ? 37  THR L C    1 
ATOM   331  O  O    . THR A 1 37  ? -8.138  -15.786 16.433  1.00 44.08  ? 37  THR L O    1 
ATOM   332  C  CB   . THR A 1 37  ? -9.910  -14.250 18.866  1.00 44.19  ? 37  THR L CB   1 
ATOM   333  O  OG1  . THR A 1 37  ? -9.729  -13.753 20.200  1.00 37.60  ? 37  THR L OG1  1 
ATOM   334  C  CG2  . THR A 1 37  ? -10.389 -15.685 18.932  1.00 45.39  ? 37  THR L CG2  1 
ATOM   335  N  N    . LYS A 1 38  ? -9.155  -13.890 15.719  1.00 46.94  ? 38  LYS L N    1 
ATOM   336  C  CA   . LYS A 1 38  ? -9.200  -14.247 14.304  1.00 54.80  ? 38  LYS L CA   1 
ATOM   337  C  C    . LYS A 1 38  ? -7.791  -14.545 13.805  1.00 50.98  ? 38  LYS L C    1 
ATOM   338  O  O    . LYS A 1 38  ? -7.557  -15.555 13.148  1.00 54.08  ? 38  LYS L O    1 
ATOM   339  C  CB   . LYS A 1 38  ? -9.812  -13.141 13.425  1.00 64.12  ? 38  LYS L CB   1 
ATOM   340  C  CG   . LYS A 1 38  ? -11.289 -13.297 13.064  1.00 80.33  ? 38  LYS L CG   1 
ATOM   341  C  CD   . LYS A 1 38  ? -12.276 -12.841 14.137  1.00 101.06 ? 38  LYS L CD   1 
ATOM   342  C  CE   . LYS A 1 38  ? -12.588 -13.891 15.186  1.00 110.07 ? 38  LYS L CE   1 
ATOM   343  N  NZ   . LYS A 1 38  ? -13.541 -13.380 16.199  1.00 111.81 ? 38  LYS L NZ   1 
ATOM   344  N  N    . LEU A 1 39  ? -6.862  -13.663 14.170  1.00 47.40  ? 39  LEU L N    1 
ATOM   345  C  CA   . LEU A 1 39  ? -5.463  -13.756 13.786  1.00 45.99  ? 39  LEU L CA   1 
ATOM   346  C  C    . LEU A 1 39  ? -4.852  -15.098 14.192  1.00 44.47  ? 39  LEU L C    1 
ATOM   347  O  O    . LEU A 1 39  ? -4.217  -15.751 13.373  1.00 54.06  ? 39  LEU L O    1 
ATOM   348  C  CB   . LEU A 1 39  ? -4.727  -12.584 14.444  1.00 46.63  ? 39  LEU L CB   1 
ATOM   349  C  CG   . LEU A 1 39  ? -3.388  -12.216 13.821  1.00 53.77  ? 39  LEU L CG   1 
ATOM   350  C  CD1  . LEU A 1 39  ? -3.532  -11.971 12.317  1.00 59.61  ? 39  LEU L CD1  1 
ATOM   351  C  CD2  . LEU A 1 39  ? -2.802  -10.991 14.499  1.00 49.95  ? 39  LEU L CD2  1 
ATOM   352  N  N    . PHE A 1 40  ? -5.022  -15.497 15.460  1.00 40.03  ? 40  PHE L N    1 
ATOM   353  C  CA   . PHE A 1 40  ? -4.585  -16.803 15.919  1.00 36.23  ? 40  PHE L CA   1 
ATOM   354  C  C    . PHE A 1 40  ? -5.316  -17.900 15.141  1.00 36.12  ? 40  PHE L C    1 
ATOM   355  O  O    . PHE A 1 40  ? -4.713  -18.895 14.738  1.00 32.01  ? 40  PHE L O    1 
ATOM   356  C  CB   . PHE A 1 40  ? -4.843  -16.954 17.419  1.00 34.16  ? 40  PHE L CB   1 
ATOM   357  C  CG   . PHE A 1 40  ? -4.766  -18.366 17.960  1.00 34.96  ? 40  PHE L CG   1 
ATOM   358  C  CD1  . PHE A 1 40  ? -3.545  -18.987 18.207  1.00 32.18  ? 40  PHE L CD1  1 
ATOM   359  C  CD2  . PHE A 1 40  ? -5.934  -19.086 18.209  1.00 32.66  ? 40  PHE L CD2  1 
ATOM   360  C  CE1  . PHE A 1 40  ? -3.512  -20.273 18.734  1.00 32.33  ? 40  PHE L CE1  1 
ATOM   361  C  CE2  . PHE A 1 40  ? -5.894  -20.374 18.717  1.00 29.28  ? 40  PHE L CE2  1 
ATOM   362  C  CZ   . PHE A 1 40  ? -4.687  -20.968 18.977  1.00 30.14  ? 40  PHE L CZ   1 
ATOM   363  N  N    . TRP A 1 41  ? -6.631  -17.712 14.958  1.00 36.05  ? 41  TRP L N    1 
ATOM   364  C  CA   . TRP A 1 41  ? -7.504  -18.792 14.525  1.00 35.06  ? 41  TRP L CA   1 
ATOM   365  C  C    . TRP A 1 41  ? -7.228  -19.171 13.072  1.00 36.22  ? 41  TRP L C    1 
ATOM   366  O  O    . TRP A 1 41  ? -7.280  -20.357 12.748  1.00 36.16  ? 41  TRP L O    1 
ATOM   367  C  CB   . TRP A 1 41  ? -8.984  -18.422 14.714  1.00 33.02  ? 41  TRP L CB   1 
ATOM   368  C  CG   . TRP A 1 41  ? -9.880  -19.621 14.575  1.00 30.89  ? 41  TRP L CG   1 
ATOM   369  C  CD1  . TRP A 1 41  ? -10.792 -19.887 13.600  1.00 26.89  ? 41  TRP L CD1  1 
ATOM   370  C  CD2  . TRP A 1 41  ? -9.894  -20.749 15.473  1.00 31.75  ? 41  TRP L CD2  1 
ATOM   371  N  NE1  . TRP A 1 41  ? -11.371 -21.104 13.824  1.00 27.87  ? 41  TRP L NE1  1 
ATOM   372  C  CE2  . TRP A 1 41  ? -10.848 -21.660 14.966  1.00 31.33  ? 41  TRP L CE2  1 
ATOM   373  C  CE3  . TRP A 1 41  ? -9.205  -21.066 16.648  1.00 31.79  ? 41  TRP L CE3  1 
ATOM   374  C  CZ2  . TRP A 1 41  ? -11.132 -22.870 15.608  1.00 30.17  ? 41  TRP L CZ2  1 
ATOM   375  C  CZ3  . TRP A 1 41  ? -9.486  -22.263 17.279  1.00 34.81  ? 41  TRP L CZ3  1 
ATOM   376  C  CH2  . TRP A 1 41  ? -10.425 -23.162 16.755  1.00 31.83  ? 41  TRP L CH2  1 
ATOM   377  N  N    . ILE A 1 42  ? -6.954  -18.162 12.222  1.00 36.57  ? 42  ILE L N    1 
ATOM   378  C  CA   . ILE A 1 42  ? -6.705  -18.373 10.801  1.00 44.33  ? 42  ILE L CA   1 
ATOM   379  C  C    . ILE A 1 42  ? -5.725  -19.539 10.578  1.00 46.39  ? 42  ILE L C    1 
ATOM   380  O  O    . ILE A 1 42  ? -6.000  -20.426 9.771   1.00 48.83  ? 42  ILE L O    1 
ATOM   381  C  CB   . ILE A 1 42  ? -6.175  -17.098 10.105  1.00 48.72  ? 42  ILE L CB   1 
ATOM   382  C  CG1  . ILE A 1 42  ? -7.145  -15.911 10.155  1.00 55.30  ? 42  ILE L CG1  1 
ATOM   383  C  CG2  . ILE A 1 42  ? -5.820  -17.425 8.660   1.00 50.27  ? 42  ILE L CG2  1 
ATOM   384  C  CD1  . ILE A 1 42  ? -6.486  -14.546 9.876   1.00 54.39  ? 42  ILE L CD1  1 
ATOM   385  N  N    . SER A 1 43  ? -4.556  -19.480 11.241  1.00 42.35  ? 43  SER L N    1 
ATOM   386  C  CA   . SER A 1 43  ? -3.456  -20.406 11.026  1.00 40.08  ? 43  SER L CA   1 
ATOM   387  C  C    . SER A 1 43  ? -3.687  -21.686 11.817  1.00 42.06  ? 43  SER L C    1 
ATOM   388  O  O    . SER A 1 43  ? -3.309  -22.755 11.340  1.00 40.42  ? 43  SER L O    1 
ATOM   389  C  CB   . SER A 1 43  ? -2.118  -19.814 11.428  1.00 38.82  ? 43  SER L CB   1 
ATOM   390  O  OG   . SER A 1 43  ? -1.864  -18.593 10.760  1.00 42.01  ? 43  SER L OG   1 
ATOM   391  N  N    . TYR A 1 44  ? -4.226  -21.547 13.044  1.00 40.35  ? 44  TYR L N    1 
ATOM   392  C  CA   . TYR A 1 44  ? -4.436  -22.677 13.940  1.00 42.42  ? 44  TYR L CA   1 
ATOM   393  C  C    . TYR A 1 44  ? -5.429  -23.668 13.340  1.00 41.95  ? 44  TYR L C    1 
ATOM   394  O  O    . TYR A 1 44  ? -5.216  -24.875 13.398  1.00 41.14  ? 44  TYR L O    1 
ATOM   395  C  CB   . TYR A 1 44  ? -5.002  -22.206 15.278  1.00 41.77  ? 44  TYR L CB   1 
ATOM   396  C  CG   . TYR A 1 44  ? -5.257  -23.293 16.312  1.00 40.84  ? 44  TYR L CG   1 
ATOM   397  C  CD1  . TYR A 1 44  ? -4.210  -23.895 16.992  1.00 41.83  ? 44  TYR L CD1  1 
ATOM   398  C  CD2  . TYR A 1 44  ? -6.546  -23.693 16.636  1.00 40.19  ? 44  TYR L CD2  1 
ATOM   399  C  CE1  . TYR A 1 44  ? -4.437  -24.871 17.946  1.00 40.87  ? 44  TYR L CE1  1 
ATOM   400  C  CE2  . TYR A 1 44  ? -6.784  -24.667 17.589  1.00 35.39  ? 44  TYR L CE2  1 
ATOM   401  C  CZ   . TYR A 1 44  ? -5.727  -25.248 18.251  1.00 36.07  ? 44  TYR L CZ   1 
ATOM   402  O  OH   . TYR A 1 44  ? -5.942  -26.204 19.194  1.00 41.72  ? 44  TYR L OH   1 
ATOM   403  N  N    . SER A 1 45  ? -6.501  -23.127 12.757  1.00 41.14  ? 45  SER L N    1 
ATOM   404  C  CA   . SER A 1 45  ? -7.627  -23.926 12.304  1.00 47.72  ? 45  SER L CA   1 
ATOM   405  C  C    . SER A 1 45  ? -7.392  -24.478 10.901  1.00 56.21  ? 45  SER L C    1 
ATOM   406  O  O    . SER A 1 45  ? -8.215  -25.241 10.407  1.00 60.35  ? 45  SER L O    1 
ATOM   407  C  CB   . SER A 1 45  ? -8.905  -23.107 12.343  1.00 46.09  ? 45  SER L CB   1 
ATOM   408  O  OG   . SER A 1 45  ? -8.828  -22.002 11.462  1.00 41.58  ? 45  SER L OG   1 
ATOM   409  N  N    . ASP A 1 46  ? -6.282  -24.082 10.261  1.00 62.86  ? 46  ASP L N    1 
ATOM   410  C  CA   . ASP A 1 46  ? -6.072  -24.356 8.849   1.00 62.96  ? 46  ASP L CA   1 
ATOM   411  C  C    . ASP A 1 46  ? -5.679  -25.822 8.683   1.00 59.40  ? 46  ASP L C    1 
ATOM   412  O  O    . ASP A 1 46  ? -6.166  -26.503 7.780   1.00 62.46  ? 46  ASP L O    1 
ATOM   413  C  CB   . ASP A 1 46  ? -5.037  -23.392 8.251   1.00 65.71  ? 46  ASP L CB   1 
ATOM   414  C  CG   . ASP A 1 46  ? -4.820  -23.554 6.753   1.00 66.32  ? 46  ASP L CG   1 
ATOM   415  O  OD1  . ASP A 1 46  ? -5.789  -23.367 6.006   1.00 65.79  ? 46  ASP L OD1  1 
ATOM   416  O  OD2  . ASP A 1 46  ? -3.686  -23.863 6.345   1.00 61.86  ? 46  ASP L OD2  1 
ATOM   417  N  N    . GLY A 1 47  ? -4.783  -26.302 9.545   1.00 51.81  ? 47  GLY L N    1 
ATOM   418  C  CA   . GLY A 1 47  ? -4.313  -27.671 9.421   1.00 59.35  ? 47  GLY L CA   1 
ATOM   419  C  C    . GLY A 1 47  ? -3.184  -27.829 8.399   1.00 56.79  ? 47  GLY L C    1 
ATOM   420  O  O    . GLY A 1 47  ? -2.950  -26.951 7.567   1.00 57.94  ? 47  GLY L O    1 
ATOM   421  N  N    . ASP A 1 48  ? -2.496  -28.974 8.502   1.00 47.48  ? 48  ASP L N    1 
ATOM   422  C  CA   . ASP A 1 48  ? -1.313  -29.285 7.731   1.00 46.29  ? 48  ASP L CA   1 
ATOM   423  C  C    . ASP A 1 48  ? -1.743  -30.014 6.459   1.00 49.82  ? 48  ASP L C    1 
ATOM   424  O  O    . ASP A 1 48  ? -2.028  -31.211 6.487   1.00 49.96  ? 48  ASP L O    1 
ATOM   425  C  CB   . ASP A 1 48  ? -0.343  -30.087 8.598   1.00 46.56  ? 48  ASP L CB   1 
ATOM   426  C  CG   . ASP A 1 48  ? 1.096   -30.029 8.119   1.00 51.67  ? 48  ASP L CG   1 
ATOM   427  O  OD1  . ASP A 1 48  ? 1.715   -28.951 8.226   1.00 57.69  ? 48  ASP L OD1  1 
ATOM   428  O  OD2  . ASP A 1 48  ? 1.587   -31.063 7.648   1.00 59.34  ? 48  ASP L OD2  1 
ATOM   429  N  N    . GLN A 1 49  ? -1.800  -29.281 5.338   1.00 48.83  ? 49  GLN L N    1 
ATOM   430  C  CA   . GLN A 1 49  ? -2.135  -29.871 4.055   1.00 45.92  ? 49  GLN L CA   1 
ATOM   431  C  C    . GLN A 1 49  ? -1.022  -30.819 3.616   1.00 39.15  ? 49  GLN L C    1 
ATOM   432  O  O    . GLN A 1 49  ? -1.226  -31.617 2.713   1.00 37.13  ? 49  GLN L O    1 
ATOM   433  C  CB   . GLN A 1 49  ? -2.381  -28.797 2.998   1.00 50.74  ? 49  GLN L CB   1 
ATOM   434  C  CG   . GLN A 1 49  ? -3.747  -28.126 3.105   1.00 59.81  ? 49  GLN L CG   1 
ATOM   435  C  CD   . GLN A 1 49  ? -3.859  -27.115 4.227   1.00 63.49  ? 49  GLN L CD   1 
ATOM   436  O  OE1  . GLN A 1 49  ? -2.923  -26.362 4.516   1.00 62.46  ? 49  GLN L OE1  1 
ATOM   437  N  NE2  . GLN A 1 49  ? -5.019  -27.088 4.873   1.00 57.78  ? 49  GLN L NE2  1 
ATOM   438  N  N    . CYS A 1 50  ? 0.131   -30.751 4.288   1.00 41.74  ? 50  CYS L N    1 
ATOM   439  C  CA   . CYS A 1 50  ? 1.254   -31.637 4.018   1.00 45.30  ? 50  CYS L CA   1 
ATOM   440  C  C    . CYS A 1 50  ? 1.124   -32.992 4.722   1.00 53.32  ? 50  CYS L C    1 
ATOM   441  O  O    . CYS A 1 50  ? 1.980   -33.851 4.524   1.00 56.98  ? 50  CYS L O    1 
ATOM   442  C  CB   . CYS A 1 50  ? 2.567   -30.988 4.446   1.00 40.68  ? 50  CYS L CB   1 
ATOM   443  S  SG   . CYS A 1 50  ? 3.107   -29.647 3.352   1.00 37.47  ? 50  CYS L SG   1 
ATOM   444  N  N    . ALA A 1 51  ? 0.077   -33.193 5.536   1.00 60.76  ? 51  ALA L N    1 
ATOM   445  C  CA   . ALA A 1 51  ? -0.075  -34.422 6.310   1.00 64.31  ? 51  ALA L CA   1 
ATOM   446  C  C    . ALA A 1 51  ? -0.363  -35.602 5.383   1.00 58.99  ? 51  ALA L C    1 
ATOM   447  O  O    . ALA A 1 51  ? 0.053   -36.723 5.663   1.00 60.26  ? 51  ALA L O    1 
ATOM   448  C  CB   . ALA A 1 51  ? -1.166  -34.276 7.350   1.00 64.67  ? 51  ALA L CB   1 
ATOM   449  N  N    . SER A 1 52  ? -1.054  -35.325 4.273   1.00 52.97  ? 52  SER L N    1 
ATOM   450  C  CA   . SER A 1 52  ? -1.396  -36.332 3.279   1.00 51.83  ? 52  SER L CA   1 
ATOM   451  C  C    . SER A 1 52  ? -0.159  -36.759 2.473   1.00 49.83  ? 52  SER L C    1 
ATOM   452  O  O    . SER A 1 52  ? -0.223  -37.636 1.617   1.00 47.08  ? 52  SER L O    1 
ATOM   453  C  CB   . SER A 1 52  ? -2.538  -35.797 2.445   1.00 53.00  ? 52  SER L CB   1 
ATOM   454  O  OG   . SER A 1 52  ? -2.381  -36.067 1.064   1.00 63.50  ? 52  SER L OG   1 
ATOM   455  N  N    . SER A 1 53  ? 0.997   -36.171 2.792   1.00 52.33  ? 53  SER L N    1 
ATOM   456  C  CA   . SER A 1 53  ? 2.233   -36.426 2.068   1.00 54.94  ? 53  SER L CA   1 
ATOM   457  C  C    . SER A 1 53  ? 2.005   -36.412 0.555   1.00 48.01  ? 53  SER L C    1 
ATOM   458  O  O    . SER A 1 53  ? 2.099   -37.433 -0.109  1.00 46.88  ? 53  SER L O    1 
ATOM   459  C  CB   . SER A 1 53  ? 2.845   -37.709 2.544   1.00 54.20  ? 53  SER L CB   1 
ATOM   460  O  OG   . SER A 1 53  ? 3.248   -37.549 3.891   1.00 54.29  ? 53  SER L OG   1 
ATOM   461  N  N    . PRO A 1 54  ? 1.688   -35.249 -0.046  1.00 44.50  ? 54  PRO L N    1 
ATOM   462  C  CA   . PRO A 1 54  ? 1.425   -35.187 -1.484  1.00 42.80  ? 54  PRO L CA   1 
ATOM   463  C  C    . PRO A 1 54  ? 2.683   -35.195 -2.349  1.00 38.70  ? 54  PRO L C    1 
ATOM   464  O  O    . PRO A 1 54  ? 2.640   -35.658 -3.488  1.00 40.49  ? 54  PRO L O    1 
ATOM   465  C  CB   . PRO A 1 54  ? 0.670   -33.862 -1.629  1.00 43.31  ? 54  PRO L CB   1 
ATOM   466  C  CG   . PRO A 1 54  ? 1.232   -33.003 -0.521  1.00 44.16  ? 54  PRO L CG   1 
ATOM   467  C  CD   . PRO A 1 54  ? 1.538   -33.948 0.623   1.00 43.27  ? 54  PRO L CD   1 
ATOM   468  N  N    . CYS A 1 55  ? 3.798   -34.686 -1.808  1.00 33.86  ? 55  CYS L N    1 
ATOM   469  C  CA   . CYS A 1 55  ? 5.017   -34.581 -2.591  1.00 35.39  ? 55  CYS L CA   1 
ATOM   470  C  C    . CYS A 1 55  ? 5.637   -35.973 -2.776  1.00 38.51  ? 55  CYS L C    1 
ATOM   471  O  O    . CYS A 1 55  ? 5.934   -36.684 -1.810  1.00 41.84  ? 55  CYS L O    1 
ATOM   472  C  CB   . CYS A 1 55  ? 5.992   -33.573 -1.989  1.00 32.66  ? 55  CYS L CB   1 
ATOM   473  S  SG   . CYS A 1 55  ? 5.251   -31.964 -1.598  1.00 30.42  ? 55  CYS L SG   1 
ATOM   474  N  N    . GLN A 1 56  ? 5.818   -36.357 -4.047  1.00 39.84  ? 56  GLN L N    1 
ATOM   475  C  CA   . GLN A 1 56  ? 6.318   -37.671 -4.428  1.00 39.90  ? 56  GLN L CA   1 
ATOM   476  C  C    . GLN A 1 56  ? 7.799   -37.570 -4.776  1.00 38.67  ? 56  GLN L C    1 
ATOM   477  O  O    . GLN A 1 56  ? 8.327   -36.475 -4.929  1.00 37.24  ? 56  GLN L O    1 
ATOM   478  C  CB   . GLN A 1 56  ? 5.545   -38.210 -5.635  1.00 42.21  ? 56  GLN L CB   1 
ATOM   479  C  CG   . GLN A 1 56  ? 4.030   -38.164 -5.469  1.00 44.04  ? 56  GLN L CG   1 
ATOM   480  C  CD   . GLN A 1 56  ? 3.327   -38.522 -6.755  1.00 48.18  ? 56  GLN L CD   1 
ATOM   481  O  OE1  . GLN A 1 56  ? 3.954   -38.920 -7.734  1.00 53.70  ? 56  GLN L OE1  1 
ATOM   482  N  NE2  . GLN A 1 56  ? 2.013   -38.352 -6.780  1.00 51.41  ? 56  GLN L NE2  1 
ATOM   483  N  N    . ASN A 1 57  ? 8.462   -38.726 -4.859  1.00 38.75  ? 57  ASN L N    1 
ATOM   484  C  CA   . ASN A 1 57  ? 9.783   -38.842 -5.463  1.00 38.33  ? 57  ASN L CA   1 
ATOM   485  C  C    . ASN A 1 57  ? 10.815  -38.027 -4.674  1.00 33.71  ? 57  ASN L C    1 
ATOM   486  O  O    . ASN A 1 57  ? 11.726  -37.426 -5.251  1.00 28.49  ? 57  ASN L O    1 
ATOM   487  C  CB   . ASN A 1 57  ? 9.709   -38.514 -6.961  1.00 40.93  ? 57  ASN L CB   1 
ATOM   488  C  CG   . ASN A 1 57  ? 8.735   -39.419 -7.692  1.00 44.74  ? 57  ASN L CG   1 
ATOM   489  O  OD1  . ASN A 1 57  ? 7.743   -38.965 -8.257  1.00 43.63  ? 57  ASN L OD1  1 
ATOM   490  N  ND2  . ASN A 1 57  ? 8.999   -40.715 -7.673  1.00 45.87  ? 57  ASN L ND2  1 
ATOM   491  N  N    . GLY A 1 58  ? 10.677  -38.035 -3.343  1.00 32.67  ? 58  GLY L N    1 
ATOM   492  C  CA   . GLY A 1 58  ? 11.693  -37.498 -2.454  1.00 32.52  ? 58  GLY L CA   1 
ATOM   493  C  C    . GLY A 1 58  ? 11.545  -35.993 -2.249  1.00 37.28  ? 58  GLY L C    1 
ATOM   494  O  O    . GLY A 1 58  ? 12.441  -35.338 -1.720  1.00 43.47  ? 58  GLY L O    1 
ATOM   495  N  N    . GLY A 1 59  ? 10.398  -35.437 -2.659  1.00 39.22  ? 59  GLY L N    1 
ATOM   496  C  CA   . GLY A 1 59  ? 10.155  -34.013 -2.516  1.00 33.61  ? 59  GLY L CA   1 
ATOM   497  C  C    . GLY A 1 59  ? 9.811   -33.648 -1.077  1.00 34.38  ? 59  GLY L C    1 
ATOM   498  O  O    . GLY A 1 59  ? 9.336   -34.480 -0.314  1.00 36.03  ? 59  GLY L O    1 
ATOM   499  N  N    . SER A 1 60  ? 10.046  -32.385 -0.731  1.00 34.84  ? 60  SER L N    1 
ATOM   500  C  CA   . SER A 1 60  ? 9.704   -31.869 0.579   1.00 33.78  ? 60  SER L CA   1 
ATOM   501  C  C    . SER A 1 60  ? 8.518   -30.895 0.505   1.00 32.86  ? 60  SER L C    1 
ATOM   502  O  O    . SER A 1 60  ? 8.398   -30.079 -0.408  1.00 31.69  ? 60  SER L O    1 
ATOM   503  C  CB   . SER A 1 60  ? 10.936  -31.294 1.197   1.00 34.26  ? 60  SER L CB   1 
ATOM   504  O  OG   . SER A 1 60  ? 11.940  -32.299 1.183   1.00 37.97  ? 60  SER L OG   1 
ATOM   505  N  N    . CYS A 1 61  ? 7.633   -31.012 1.500   1.00 31.49  ? 61  CYS L N    1 
ATOM   506  C  CA   . CYS A 1 61  ? 6.357   -30.331 1.528   1.00 32.41  ? 61  CYS L CA   1 
ATOM   507  C  C    . CYS A 1 61  ? 6.437   -29.177 2.516   1.00 33.93  ? 61  CYS L C    1 
ATOM   508  O  O    . CYS A 1 61  ? 6.864   -29.363 3.646   1.00 38.32  ? 61  CYS L O    1 
ATOM   509  C  CB   . CYS A 1 61  ? 5.265   -31.314 1.921   1.00 32.86  ? 61  CYS L CB   1 
ATOM   510  S  SG   . CYS A 1 61  ? 3.585   -30.695 1.658   1.00 35.02  ? 61  CYS L SG   1 
ATOM   511  N  N    . LYS A 1 62  ? 6.055   -27.983 2.065   1.00 35.90  ? 62  LYS L N    1 
ATOM   512  C  CA   . LYS A 1 62  ? 5.955   -26.824 2.939   1.00 38.79  ? 62  LYS L CA   1 
ATOM   513  C  C    . LYS A 1 62  ? 4.497   -26.345 2.981   1.00 35.92  ? 62  LYS L C    1 
ATOM   514  O  O    . LYS A 1 62  ? 3.862   -26.106 1.951   1.00 28.54  ? 62  LYS L O    1 
ATOM   515  C  CB   . LYS A 1 62  ? 6.909   -25.711 2.487   1.00 38.82  ? 62  LYS L CB   1 
ATOM   516  C  CG   . LYS A 1 62  ? 6.685   -24.358 3.154   1.00 40.91  ? 62  LYS L CG   1 
ATOM   517  C  CD   . LYS A 1 62  ? 7.153   -24.288 4.597   1.00 44.26  ? 62  LYS L CD   1 
ATOM   518  C  CE   . LYS A 1 62  ? 6.960   -22.913 5.205   1.00 46.19  ? 62  LYS L CE   1 
ATOM   519  N  NZ   . LYS A 1 62  ? 5.557   -22.673 5.646   1.00 49.29  ? 62  LYS L NZ   1 
ATOM   520  N  N    . ASP A 1 63  ? 3.998   -26.179 4.208   1.00 36.56  ? 63  ASP L N    1 
ATOM   521  C  CA   . ASP A 1 63  ? 2.595   -25.943 4.469   1.00 35.36  ? 63  ASP L CA   1 
ATOM   522  C  C    . ASP A 1 63  ? 2.303   -24.469 4.198   1.00 33.24  ? 63  ASP L C    1 
ATOM   523  O  O    . ASP A 1 63  ? 3.163   -23.605 4.356   1.00 31.03  ? 63  ASP L O    1 
ATOM   524  C  CB   . ASP A 1 63  ? 2.252   -26.429 5.880   1.00 39.47  ? 63  ASP L CB   1 
ATOM   525  C  CG   . ASP A 1 63  ? 0.772   -26.343 6.240   1.00 45.05  ? 63  ASP L CG   1 
ATOM   526  O  OD1  . ASP A 1 63  ? -0.080  -26.844 5.441   1.00 42.92  ? 63  ASP L OD1  1 
ATOM   527  O  OD2  . ASP A 1 63  ? 0.463   -25.750 7.312   1.00 47.63  ? 63  ASP L OD2  1 
ATOM   528  N  N    . GLN A 1 64  ? 1.091   -24.199 3.710   1.00 34.72  ? 64  GLN L N    1 
ATOM   529  C  CA   . GLN A 1 64  ? 0.675   -22.839 3.427   1.00 39.08  ? 64  GLN L CA   1 
ATOM   530  C  C    . GLN A 1 64  ? -0.704  -22.644 4.034   1.00 39.38  ? 64  GLN L C    1 
ATOM   531  O  O    . GLN A 1 64  ? -1.095  -23.396 4.908   1.00 43.14  ? 64  GLN L O    1 
ATOM   532  C  CB   . GLN A 1 64  ? 0.698   -22.565 1.918   1.00 39.66  ? 64  GLN L CB   1 
ATOM   533  C  CG   . GLN A 1 64  ? 2.082   -22.652 1.300   1.00 38.97  ? 64  GLN L CG   1 
ATOM   534  C  CD   . GLN A 1 64  ? 3.014   -21.606 1.859   1.00 39.48  ? 64  GLN L CD   1 
ATOM   535  O  OE1  . GLN A 1 64  ? 2.697   -20.421 1.905   1.00 38.43  ? 64  GLN L OE1  1 
ATOM   536  N  NE2  . GLN A 1 64  ? 4.178   -22.047 2.297   1.00 40.56  ? 64  GLN L NE2  1 
ATOM   537  N  N    . LEU A 1 65  ? -1.410  -21.602 3.604   1.00 44.02  ? 65  LEU L N    1 
ATOM   538  C  CA   . LEU A 1 65  ? -2.780  -21.416 4.016   1.00 48.40  ? 65  LEU L CA   1 
ATOM   539  C  C    . LEU A 1 65  ? -3.667  -22.027 2.940   1.00 47.60  ? 65  LEU L C    1 
ATOM   540  O  O    . LEU A 1 65  ? -3.746  -21.472 1.857   1.00 48.78  ? 65  LEU L O    1 
ATOM   541  C  CB   . LEU A 1 65  ? -3.026  -19.914 4.203   1.00 51.33  ? 65  LEU L CB   1 
ATOM   542  C  CG   . LEU A 1 65  ? -3.960  -19.537 5.351   1.00 54.02  ? 65  LEU L CG   1 
ATOM   543  C  CD1  . LEU A 1 65  ? -3.439  -20.071 6.686   1.00 58.62  ? 65  LEU L CD1  1 
ATOM   544  C  CD2  . LEU A 1 65  ? -4.130  -18.031 5.422   1.00 53.30  ? 65  LEU L CD2  1 
ATOM   545  N  N    . GLN A 1 66  ? -4.280  -23.184 3.247   1.00 52.35  ? 66  GLN L N    1 
ATOM   546  C  CA   . GLN A 1 66  ? -5.244  -23.873 2.386   1.00 51.70  ? 66  GLN L CA   1 
ATOM   547  C  C    . GLN A 1 66  ? -4.561  -24.359 1.105   1.00 46.40  ? 66  GLN L C    1 
ATOM   548  O  O    . GLN A 1 66  ? -5.218  -24.470 0.071   1.00 43.41  ? 66  GLN L O    1 
ATOM   549  C  CB   . GLN A 1 66  ? -6.450  -22.998 1.993   1.00 52.98  ? 66  GLN L CB   1 
ATOM   550  C  CG   . GLN A 1 66  ? -7.288  -22.450 3.152   1.00 57.49  ? 66  GLN L CG   1 
ATOM   551  C  CD   . GLN A 1 66  ? -8.071  -23.515 3.887   1.00 62.56  ? 66  GLN L CD   1 
ATOM   552  O  OE1  . GLN A 1 66  ? -8.021  -23.631 5.114   1.00 55.09  ? 66  GLN L OE1  1 
ATOM   553  N  NE2  . GLN A 1 66  ? -8.802  -24.318 3.128   1.00 62.22  ? 66  GLN L NE2  1 
ATOM   554  N  N    . SER A 1 67  ? -3.252  -24.638 1.182   1.00 37.57  ? 67  SER L N    1 
ATOM   555  C  CA   . SER A 1 67  ? -2.489  -25.111 0.039   1.00 34.51  ? 67  SER L CA   1 
ATOM   556  C  C    . SER A 1 67  ? -1.125  -25.581 0.531   1.00 30.86  ? 67  SER L C    1 
ATOM   557  O  O    . SER A 1 67  ? -0.883  -25.580 1.738   1.00 30.23  ? 67  SER L O    1 
ATOM   558  C  CB   . SER A 1 67  ? -2.371  -24.045 -1.038  1.00 36.08  ? 67  SER L CB   1 
ATOM   559  O  OG   . SER A 1 67  ? -1.878  -22.840 -0.474  1.00 41.31  ? 67  SER L OG   1 
ATOM   560  N  N    . TYR A 1 68  ? -0.257  -26.015 -0.395  1.00 27.09  ? 68  TYR L N    1 
ATOM   561  C  CA   . TYR A 1 68  ? 1.118   -26.328 -0.041  1.00 27.96  ? 68  TYR L CA   1 
ATOM   562  C  C    . TYR A 1 68  ? 2.043   -26.060 -1.228  1.00 25.30  ? 68  TYR L C    1 
ATOM   563  O  O    . TYR A 1 68  ? 1.592   -25.671 -2.279  1.00 23.46  ? 68  TYR L O    1 
ATOM   564  C  CB   . TYR A 1 68  ? 1.166   -27.781 0.441   1.00 28.18  ? 68  TYR L CB   1 
ATOM   565  C  CG   . TYR A 1 68  ? 0.689   -28.725 -0.644  1.00 31.08  ? 68  TYR L CG   1 
ATOM   566  C  CD1  . TYR A 1 68  ? 1.533   -29.130 -1.678  1.00 30.37  ? 68  TYR L CD1  1 
ATOM   567  C  CD2  . TYR A 1 68  ? -0.646  -29.119 -0.689  1.00 35.05  ? 68  TYR L CD2  1 
ATOM   568  C  CE1  . TYR A 1 68  ? 1.079   -29.980 -2.675  1.00 31.43  ? 68  TYR L CE1  1 
ATOM   569  C  CE2  . TYR A 1 68  ? -1.111  -29.960 -1.685  1.00 35.69  ? 68  TYR L CE2  1 
ATOM   570  C  CZ   . TYR A 1 68  ? -0.247  -30.384 -2.684  1.00 33.83  ? 68  TYR L CZ   1 
ATOM   571  O  OH   . TYR A 1 68  ? -0.723  -31.171 -3.688  1.00 34.89  ? 68  TYR L OH   1 
ATOM   572  N  N    . ILE A 1 69  ? 3.345   -26.281 -1.025  1.00 29.31  ? 69  ILE L N    1 
ATOM   573  C  CA   . ILE A 1 69  ? 4.388   -26.151 -2.028  1.00 29.63  ? 69  ILE L CA   1 
ATOM   574  C  C    . ILE A 1 69  ? 5.253   -27.397 -1.938  1.00 30.17  ? 69  ILE L C    1 
ATOM   575  O  O    . ILE A 1 69  ? 5.771   -27.714 -0.862  1.00 29.69  ? 69  ILE L O    1 
ATOM   576  C  CB   . ILE A 1 69  ? 5.245   -24.908 -1.740  1.00 34.02  ? 69  ILE L CB   1 
ATOM   577  C  CG1  . ILE A 1 69  ? 4.499   -23.608 -1.973  1.00 36.72  ? 69  ILE L CG1  1 
ATOM   578  C  CG2  . ILE A 1 69  ? 6.517   -24.902 -2.555  1.00 41.23  ? 69  ILE L CG2  1 
ATOM   579  C  CD1  . ILE A 1 69  ? 5.242   -22.471 -1.361  1.00 43.51  ? 69  ILE L CD1  1 
ATOM   580  N  N    . CYS A 1 70  ? 5.434   -28.075 -3.075  1.00 30.82  ? 70  CYS L N    1 
ATOM   581  C  CA   . CYS A 1 70  ? 6.386   -29.174 -3.160  1.00 27.22  ? 70  CYS L CA   1 
ATOM   582  C  C    . CYS A 1 70  ? 7.690   -28.669 -3.761  1.00 26.77  ? 70  CYS L C    1 
ATOM   583  O  O    . CYS A 1 70  ? 7.692   -28.050 -4.833  1.00 28.77  ? 70  CYS L O    1 
ATOM   584  C  CB   . CYS A 1 70  ? 5.867   -30.330 -4.004  1.00 28.54  ? 70  CYS L CB   1 
ATOM   585  S  SG   . CYS A 1 70  ? 4.448   -31.201 -3.287  1.00 29.70  ? 70  CYS L SG   1 
ATOM   586  N  N    . PHE A 1 71  ? 8.782   -28.943 -3.038  1.00 24.89  ? 71  PHE L N    1 
ATOM   587  C  CA   . PHE A 1 71  ? 10.133  -28.747 -3.519  1.00 25.43  ? 71  PHE L CA   1 
ATOM   588  C  C    . PHE A 1 71  ? 10.650  -30.082 -4.036  1.00 27.49  ? 71  PHE L C    1 
ATOM   589  O  O    . PHE A 1 71  ? 10.596  -31.052 -3.280  1.00 25.89  ? 71  PHE L O    1 
ATOM   590  C  CB   . PHE A 1 71  ? 11.037  -28.279 -2.372  1.00 24.74  ? 71  PHE L CB   1 
ATOM   591  C  CG   . PHE A 1 71  ? 10.655  -26.965 -1.757  1.00 24.31  ? 71  PHE L CG   1 
ATOM   592  C  CD1  . PHE A 1 71  ? 11.495  -25.868 -1.871  1.00 25.82  ? 71  PHE L CD1  1 
ATOM   593  C  CD2  . PHE A 1 71  ? 9.476   -26.824 -1.040  1.00 24.04  ? 71  PHE L CD2  1 
ATOM   594  C  CE1  . PHE A 1 71  ? 11.136  -24.645 -1.320  1.00 26.32  ? 71  PHE L CE1  1 
ATOM   595  C  CE2  . PHE A 1 71  ? 9.137   -25.605 -0.473  1.00 24.30  ? 71  PHE L CE2  1 
ATOM   596  C  CZ   . PHE A 1 71  ? 9.960   -24.517 -0.617  1.00 25.03  ? 71  PHE L CZ   1 
ATOM   597  N  N    . CYS A 1 72  ? 11.179  -30.112 -5.276  1.00 29.34  ? 72  CYS L N    1 
ATOM   598  C  CA   . CYS A 1 72  ? 11.476  -31.365 -5.957  1.00 28.39  ? 72  CYS L CA   1 
ATOM   599  C  C    . CYS A 1 72  ? 12.981  -31.583 -6.092  1.00 30.92  ? 72  CYS L C    1 
ATOM   600  O  O    . CYS A 1 72  ? 13.741  -30.634 -6.234  1.00 31.15  ? 72  CYS L O    1 
ATOM   601  C  CB   . CYS A 1 72  ? 10.884  -31.437 -7.364  1.00 28.02  ? 72  CYS L CB   1 
ATOM   602  S  SG   . CYS A 1 72  ? 9.095   -31.181 -7.482  1.00 28.89  ? 72  CYS L SG   1 
ATOM   603  N  N    . LEU A 1 73  ? 13.388  -32.863 -6.109  1.00 34.86  ? 73  LEU L N    1 
ATOM   604  C  CA   . LEU A 1 73  ? 14.727  -33.242 -6.520  1.00 35.30  ? 73  LEU L CA   1 
ATOM   605  C  C    . LEU A 1 73  ? 14.880  -32.858 -7.988  1.00 38.04  ? 73  LEU L C    1 
ATOM   606  O  O    . LEU A 1 73  ? 13.879  -32.818 -8.706  1.00 36.75  ? 73  LEU L O    1 
ATOM   607  C  CB   . LEU A 1 73  ? 14.937  -34.745 -6.298  1.00 36.58  ? 73  LEU L CB   1 
ATOM   608  C  CG   . LEU A 1 73  ? 14.864  -35.221 -4.839  1.00 40.39  ? 73  LEU L CG   1 
ATOM   609  C  CD1  . LEU A 1 73  ? 14.949  -36.744 -4.739  1.00 43.54  ? 73  LEU L CD1  1 
ATOM   610  C  CD2  . LEU A 1 73  ? 15.951  -34.580 -3.983  1.00 36.51  ? 73  LEU L CD2  1 
ATOM   611  N  N    . PRO A 1 74  ? 16.116  -32.545 -8.462  1.00 37.39  ? 74  PRO L N    1 
ATOM   612  C  CA   . PRO A 1 74  ? 16.327  -31.976 -9.804  1.00 34.72  ? 74  PRO L CA   1 
ATOM   613  C  C    . PRO A 1 74  ? 15.673  -32.678 -11.000 1.00 31.92  ? 74  PRO L C    1 
ATOM   614  O  O    . PRO A 1 74  ? 15.235  -32.030 -11.937 1.00 27.26  ? 74  PRO L O    1 
ATOM   615  C  CB   . PRO A 1 74  ? 17.859  -32.027 -9.961  1.00 35.55  ? 74  PRO L CB   1 
ATOM   616  C  CG   . PRO A 1 74  ? 18.391  -31.930 -8.539  1.00 33.64  ? 74  PRO L CG   1 
ATOM   617  C  CD   . PRO A 1 74  ? 17.377  -32.686 -7.705  1.00 33.27  ? 74  PRO L CD   1 
ATOM   618  N  N    . ALA A 1 75  ? 15.584  -34.007 -10.975 1.00 35.11  ? 75  ALA L N    1 
ATOM   619  C  CA   . ALA A 1 75  ? 15.076  -34.744 -12.122 1.00 35.93  ? 75  ALA L CA   1 
ATOM   620  C  C    . ALA A 1 75  ? 13.545  -34.807 -12.135 1.00 36.56  ? 75  ALA L C    1 
ATOM   621  O  O    . ALA A 1 75  ? 12.960  -35.624 -12.852 1.00 42.29  ? 75  ALA L O    1 
ATOM   622  C  CB   . ALA A 1 75  ? 15.660  -36.127 -12.103 1.00 35.99  ? 75  ALA L CB   1 
ATOM   623  N  N    . PHE A 1 76  ? 12.891  -33.930 -11.368 1.00 32.24  ? 76  PHE L N    1 
ATOM   624  C  CA   . PHE A 1 76  ? 11.458  -34.018 -11.172 1.00 30.78  ? 76  PHE L CA   1 
ATOM   625  C  C    . PHE A 1 76  ? 10.845  -32.628 -11.203 1.00 28.90  ? 76  PHE L C    1 
ATOM   626  O  O    . PHE A 1 76  ? 11.503  -31.658 -10.881 1.00 28.64  ? 76  PHE L O    1 
ATOM   627  C  CB   . PHE A 1 76  ? 11.095  -34.710 -9.849  1.00 29.14  ? 76  PHE L CB   1 
ATOM   628  C  CG   . PHE A 1 76  ? 11.511  -36.151 -9.765  1.00 29.64  ? 76  PHE L CG   1 
ATOM   629  C  CD1  . PHE A 1 76  ? 10.714  -37.140 -10.312 1.00 29.17  ? 76  PHE L CD1  1 
ATOM   630  C  CD2  . PHE A 1 76  ? 12.741  -36.504 -9.211  1.00 29.68  ? 76  PHE L CD2  1 
ATOM   631  C  CE1  . PHE A 1 76  ? 11.122  -38.469 -10.279 1.00 29.92  ? 76  PHE L CE1  1 
ATOM   632  C  CE2  . PHE A 1 76  ? 13.141  -37.831 -9.187  1.00 30.55  ? 76  PHE L CE2  1 
ATOM   633  C  CZ   . PHE A 1 76  ? 12.336  -38.809 -9.739  1.00 28.81  ? 76  PHE L CZ   1 
ATOM   634  N  N    . GLU A 1 77  ? 9.558   -32.599 -11.554 1.00 28.98  ? 77  GLU L N    1 
ATOM   635  C  CA   . GLU A 1 77  ? 8.748   -31.405 -11.561 1.00 29.21  ? 77  GLU L CA   1 
ATOM   636  C  C    . GLU A 1 77  ? 7.288   -31.834 -11.446 1.00 27.75  ? 77  GLU L C    1 
ATOM   637  O  O    . GLU A 1 77  ? 7.001   -33.021 -11.322 1.00 27.17  ? 77  GLU L O    1 
ATOM   638  C  CB   . GLU A 1 77  ? 9.056   -30.578 -12.812 1.00 34.98  ? 77  GLU L CB   1 
ATOM   639  C  CG   . GLU A 1 77  ? 8.827   -31.257 -14.158 1.00 37.01  ? 77  GLU L CG   1 
ATOM   640  C  CD   . GLU A 1 77  ? 9.283   -30.359 -15.301 1.00 41.06  ? 77  GLU L CD   1 
ATOM   641  O  OE1  . GLU A 1 77  ? 9.606   -29.201 -15.031 1.00 45.45  ? 77  GLU L OE1  1 
ATOM   642  O  OE2  . GLU A 1 77  ? 9.343   -30.808 -16.445 1.00 50.54  ? 77  GLU L OE2  1 
ATOM   643  N  N    . GLY A 1 78  ? 6.383   -30.853 -11.485 1.00 26.53  ? 78  GLY L N    1 
ATOM   644  C  CA   . GLY A 1 78  ? 4.972   -31.054 -11.212 1.00 24.16  ? 78  GLY L CA   1 
ATOM   645  C  C    . GLY A 1 78  ? 4.623   -30.485 -9.838  1.00 23.50  ? 78  GLY L C    1 
ATOM   646  O  O    . GLY A 1 78  ? 5.482   -30.374 -8.958  1.00 22.34  ? 78  GLY L O    1 
ATOM   647  N  N    . ARG A 1 79  ? 3.350   -30.133 -9.673  1.00 23.96  ? 79  ARG L N    1 
ATOM   648  C  CA   . ARG A 1 79  ? 2.798   -29.726 -8.389  1.00 24.83  ? 79  ARG L CA   1 
ATOM   649  C  C    . ARG A 1 79  ? 3.254   -30.669 -7.279  1.00 25.98  ? 79  ARG L C    1 
ATOM   650  O  O    . ARG A 1 79  ? 3.762   -30.192 -6.266  1.00 30.35  ? 79  ARG L O    1 
ATOM   651  C  CB   . ARG A 1 79  ? 1.271   -29.688 -8.460  1.00 24.50  ? 79  ARG L CB   1 
ATOM   652  C  CG   . ARG A 1 79  ? 0.609   -29.305 -7.148  1.00 25.50  ? 79  ARG L CG   1 
ATOM   653  C  CD   . ARG A 1 79  ? -0.898  -29.455 -7.185  1.00 24.07  ? 79  ARG L CD   1 
ATOM   654  N  NE   . ARG A 1 79  ? -1.456  -28.862 -8.378  1.00 23.08  ? 79  ARG L NE   1 
ATOM   655  C  CZ   . ARG A 1 79  ? -1.988  -27.650 -8.442  1.00 26.37  ? 79  ARG L CZ   1 
ATOM   656  N  NH1  . ARG A 1 79  ? -1.857  -26.830 -7.404  1.00 26.88  ? 79  ARG L NH1  1 
ATOM   657  N  NH2  . ARG A 1 79  ? -2.586  -27.250 -9.564  1.00 25.54  ? 79  ARG L NH2  1 
ATOM   658  N  N    . ASN A 1 80  ? 3.108   -31.986 -7.499  1.00 25.98  ? 80  ASN L N    1 
ATOM   659  C  CA   . ASN A 1 80  ? 3.460   -33.020 -6.529  1.00 24.83  ? 80  ASN L CA   1 
ATOM   660  C  C    . ASN A 1 80  ? 4.731   -33.776 -6.913  1.00 24.15  ? 80  ASN L C    1 
ATOM   661  O  O    . ASN A 1 80  ? 4.954   -34.884 -6.424  1.00 21.62  ? 80  ASN L O    1 
ATOM   662  C  CB   . ASN A 1 80  ? 2.306   -34.000 -6.365  1.00 26.35  ? 80  ASN L CB   1 
ATOM   663  C  CG   . ASN A 1 80  ? 1.023   -33.255 -6.075  1.00 30.26  ? 80  ASN L CG   1 
ATOM   664  O  OD1  . ASN A 1 80  ? -0.005  -33.492 -6.703  1.00 32.92  ? 80  ASN L OD1  1 
ATOM   665  N  ND2  . ASN A 1 80  ? 1.085   -32.329 -5.136  1.00 32.09  ? 80  ASN L ND2  1 
ATOM   666  N  N    . CYS A 1 81  ? 5.591   -33.132 -7.722  1.00 25.46  ? 81  CYS L N    1 
ATOM   667  C  CA   . CYS A 1 81  ? 6.840   -33.720 -8.199  1.00 27.64  ? 81  CYS L CA   1 
ATOM   668  C  C    . CYS A 1 81  ? 6.537   -35.055 -8.909  1.00 28.90  ? 81  CYS L C    1 
ATOM   669  O  O    . CYS A 1 81  ? 7.311   -36.006 -8.810  1.00 29.55  ? 81  CYS L O    1 
ATOM   670  C  CB   . CYS A 1 81  ? 7.858   -33.898 -7.072  1.00 26.46  ? 81  CYS L CB   1 
ATOM   671  S  SG   . CYS A 1 81  ? 8.261   -32.406 -6.114  1.00 27.82  ? 81  CYS L SG   1 
ATOM   672  N  N    . GLU A 1 82  ? 5.418   -35.128 -9.654  1.00 27.03  ? 82  GLU L N    1 
ATOM   673  C  CA   . GLU A 1 82  ? 4.955   -36.402 -10.193 1.00 28.91  ? 82  GLU L CA   1 
ATOM   674  C  C    . GLU A 1 82  ? 5.629   -36.746 -11.529 1.00 31.12  ? 82  GLU L C    1 
ATOM   675  O  O    . GLU A 1 82  ? 5.486   -37.862 -12.018 1.00 29.66  ? 82  GLU L O    1 
ATOM   676  C  CB   . GLU A 1 82  ? 3.433   -36.425 -10.337 1.00 25.79  ? 82  GLU L CB   1 
ATOM   677  C  CG   . GLU A 1 82  ? 2.853   -35.390 -11.287 1.00 27.34  ? 82  GLU L CG   1 
ATOM   678  C  CD   . GLU A 1 82  ? 2.772   -33.975 -10.732 1.00 28.18  ? 82  GLU L CD   1 
ATOM   679  O  OE1  . GLU A 1 82  ? 3.532   -33.697 -9.779  1.00 26.37  ? 82  GLU L OE1  1 
ATOM   680  O  OE2  . GLU A 1 82  ? 1.964   -33.147 -11.261 1.00 28.89  ? 82  GLU L OE2  1 
ATOM   681  N  N    . THR A 1 83  ? 6.388   -35.804 -12.097 1.00 33.11  ? 83  THR L N    1 
ATOM   682  C  CA   . THR A 1 83  ? 6.851   -35.895 -13.472 1.00 34.67  ? 83  THR L CA   1 
ATOM   683  C  C    . THR A 1 83  ? 8.343   -36.201 -13.495 1.00 36.63  ? 83  THR L C    1 
ATOM   684  O  O    . THR A 1 83  ? 9.126   -35.418 -12.948 1.00 34.84  ? 83  THR L O    1 
ATOM   685  C  CB   . THR A 1 83  ? 6.584   -34.574 -14.208 1.00 34.25  ? 83  THR L CB   1 
ATOM   686  O  OG1  . THR A 1 83  ? 5.225   -34.204 -13.995 1.00 32.43  ? 83  THR L OG1  1 
ATOM   687  C  CG2  . THR A 1 83  ? 6.854   -34.645 -15.694 1.00 35.15  ? 83  THR L CG2  1 
ATOM   688  N  N    . HIS A 1 84  ? 8.729   -37.326 -14.121 1.00 40.15  ? 84  HIS L N    1 
ATOM   689  C  CA   . HIS A 1 84  ? 10.145  -37.641 -14.300 1.00 44.85  ? 84  HIS L CA   1 
ATOM   690  C  C    . HIS A 1 84  ? 10.657  -36.896 -15.536 1.00 42.85  ? 84  HIS L C    1 
ATOM   691  O  O    . HIS A 1 84  ? 10.188  -37.118 -16.640 1.00 36.70  ? 84  HIS L O    1 
ATOM   692  C  CB   . HIS A 1 84  ? 10.412  -39.143 -14.492 1.00 45.45  ? 84  HIS L CB   1 
ATOM   693  C  CG   . HIS A 1 84  ? 9.921   -40.070 -13.421 1.00 54.81  ? 84  HIS L CG   1 
ATOM   694  N  ND1  . HIS A 1 84  ? 8.606   -40.170 -12.999 1.00 55.28  ? 84  HIS L ND1  1 
ATOM   695  C  CD2  . HIS A 1 84  ? 10.605  -40.986 -12.703 1.00 55.24  ? 84  HIS L CD2  1 
ATOM   696  C  CE1  . HIS A 1 84  ? 8.511   -41.098 -12.053 1.00 51.97  ? 84  HIS L CE1  1 
ATOM   697  N  NE2  . HIS A 1 84  ? 9.716   -41.600 -11.848 1.00 54.29  ? 84  HIS L NE2  1 
ATOM   698  N  N    . LYS A 1 85  ? 11.641  -36.018 -15.375 1.00 45.27  ? 85  LYS L N    1 
ATOM   699  C  CA   . LYS A 1 85  ? 12.124  -35.277 -16.525 1.00 50.94  ? 85  LYS L CA   1 
ATOM   700  C  C    . LYS A 1 85  ? 12.756  -36.216 -17.546 1.00 52.38  ? 85  LYS L C    1 
ATOM   701  O  O    . LYS A 1 85  ? 12.750  -35.908 -18.732 1.00 65.83  ? 85  LYS L O    1 
ATOM   702  C  CB   . LYS A 1 85  ? 13.063  -34.170 -16.053 1.00 53.38  ? 85  LYS L CB   1 
ATOM   703  C  CG   . LYS A 1 85  ? 12.290  -33.042 -15.393 1.00 62.25  ? 85  LYS L CG   1 
ATOM   704  C  CD   . LYS A 1 85  ? 13.104  -32.122 -14.544 1.00 66.75  ? 85  LYS L CD   1 
ATOM   705  C  CE   . LYS A 1 85  ? 13.795  -31.041 -15.341 1.00 66.24  ? 85  LYS L CE   1 
ATOM   706  N  NZ   . LYS A 1 85  ? 14.332  -30.018 -14.423 1.00 70.64  ? 85  LYS L NZ   1 
ATOM   707  N  N    . ASP A 1 86  ? 13.248  -37.369 -17.088 1.00 51.63  ? 86  ASP L N    1 
ATOM   708  C  CA   . ASP A 1 86  ? 14.035  -38.275 -17.913 1.00 55.99  ? 86  ASP L CA   1 
ATOM   709  C  C    . ASP A 1 86  ? 13.134  -39.044 -18.884 1.00 49.11  ? 86  ASP L C    1 
ATOM   710  O  O    . ASP A 1 86  ? 13.614  -39.555 -19.884 1.00 50.12  ? 86  ASP L O    1 
ATOM   711  C  CB   . ASP A 1 86  ? 14.855  -39.243 -17.049 1.00 66.16  ? 86  ASP L CB   1 
ATOM   712  C  CG   . ASP A 1 86  ? 15.315  -38.674 -15.709 1.00 79.25  ? 86  ASP L CG   1 
ATOM   713  O  OD1  . ASP A 1 86  ? 16.516  -38.327 -15.600 1.00 73.84  ? 86  ASP L OD1  1 
ATOM   714  O  OD2  . ASP A 1 86  ? 14.466  -38.603 -14.762 1.00 85.47  ? 86  ASP L OD2  1 
ATOM   715  N  N    . ASP A 1 87  ? 11.828  -39.118 -18.595 1.00 46.82  ? 87  ASP L N    1 
ATOM   716  C  CA   . ASP A 1 87  ? 10.865  -39.843 -19.413 1.00 42.86  ? 87  ASP L CA   1 
ATOM   717  C  C    . ASP A 1 87  ? 10.251  -38.956 -20.496 1.00 43.41  ? 87  ASP L C    1 
ATOM   718  O  O    . ASP A 1 87  ? 9.351   -39.381 -21.224 1.00 36.58  ? 87  ASP L O    1 
ATOM   719  C  CB   . ASP A 1 87  ? 9.751   -40.382 -18.519 1.00 42.00  ? 87  ASP L CB   1 
ATOM   720  C  CG   . ASP A 1 87  ? 10.263  -41.393 -17.522 1.00 41.42  ? 87  ASP L CG   1 
ATOM   721  O  OD1  . ASP A 1 87  ? 11.328  -41.983 -17.814 1.00 41.31  ? 87  ASP L OD1  1 
ATOM   722  O  OD2  . ASP A 1 87  ? 9.606   -41.560 -16.463 1.00 41.55  ? 87  ASP L OD2  1 
ATOM   723  N  N    . GLN A 1 88  ? 10.739  -37.713 -20.578 1.00 47.59  ? 88  GLN L N    1 
ATOM   724  C  CA   . GLN A 1 88  ? 10.204  -36.716 -21.482 1.00 48.76  ? 88  GLN L CA   1 
ATOM   725  C  C    . GLN A 1 88  ? 11.113  -36.524 -22.693 1.00 43.49  ? 88  GLN L C    1 
ATOM   726  O  O    . GLN A 1 88  ? 10.978  -35.524 -23.392 1.00 42.18  ? 88  GLN L O    1 
ATOM   727  C  CB   . GLN A 1 88  ? 10.088  -35.377 -20.752 1.00 57.62  ? 88  GLN L CB   1 
ATOM   728  C  CG   . GLN A 1 88  ? 9.086   -35.352 -19.607 1.00 63.54  ? 88  GLN L CG   1 
ATOM   729  C  CD   . GLN A 1 88  ? 8.848   -33.917 -19.193 1.00 80.91  ? 88  GLN L CD   1 
ATOM   730  O  OE1  . GLN A 1 88  ? 9.776   -33.193 -18.830 1.00 78.49  ? 88  GLN L OE1  1 
ATOM   731  N  NE2  . GLN A 1 88  ? 7.603   -33.470 -19.289 1.00 90.04  ? 88  GLN L NE2  1 
ATOM   732  N  N    . LEU A 1 89  ? 12.036  -37.461 -22.944 1.00 47.78  ? 89  LEU L N    1 
ATOM   733  C  CA   . LEU A 1 89  ? 12.952  -37.351 -24.075 1.00 49.25  ? 89  LEU L CA   1 
ATOM   734  C  C    . LEU A 1 89  ? 12.241  -37.766 -25.363 1.00 42.63  ? 89  LEU L C    1 
ATOM   735  O  O    . LEU A 1 89  ? 12.508  -38.832 -25.921 1.00 43.03  ? 89  LEU L O    1 
ATOM   736  C  CB   . LEU A 1 89  ? 14.205  -38.199 -23.827 1.00 54.51  ? 89  LEU L CB   1 
ATOM   737  C  CG   . LEU A 1 89  ? 15.343  -37.998 -24.830 1.00 57.02  ? 89  LEU L CG   1 
ATOM   738  C  CD1  . LEU A 1 89  ? 16.070  -36.679 -24.567 1.00 53.46  ? 89  LEU L CD1  1 
ATOM   739  C  CD2  . LEU A 1 89  ? 16.310  -39.185 -24.802 1.00 55.20  ? 89  LEU L CD2  1 
ATOM   740  N  N    . ILE A 1 90  ? 11.364  -36.868 -25.830 1.00 36.64  ? 90  ILE L N    1 
ATOM   741  C  CA   . ILE A 1 90  ? 10.616  -37.024 -27.066 1.00 34.41  ? 90  ILE L CA   1 
ATOM   742  C  C    . ILE A 1 90  ? 10.903  -35.809 -27.960 1.00 28.10  ? 90  ILE L C    1 
ATOM   743  O  O    . ILE A 1 90  ? 11.335  -34.763 -27.478 1.00 24.13  ? 90  ILE L O    1 
ATOM   744  C  CB   . ILE A 1 90  ? 9.120   -37.240 -26.751 1.00 34.23  ? 90  ILE L CB   1 
ATOM   745  C  CG1  . ILE A 1 90  ? 8.509   -36.070 -25.973 1.00 37.90  ? 90  ILE L CG1  1 
ATOM   746  C  CG2  . ILE A 1 90  ? 8.932   -38.545 -26.010 1.00 31.65  ? 90  ILE L CG2  1 
ATOM   747  C  CD1  . ILE A 1 90  ? 7.081   -36.281 -25.543 1.00 37.87  ? 90  ILE L CD1  1 
ATOM   748  N  N    . CYS A 1 91  ? 10.681  -35.979 -29.268 1.00 24.39  ? 91  CYS L N    1 
ATOM   749  C  CA   . CYS A 1 91  ? 11.141  -35.036 -30.275 1.00 23.93  ? 91  CYS L CA   1 
ATOM   750  C  C    . CYS A 1 91  ? 10.421  -33.701 -30.175 1.00 25.13  ? 91  CYS L C    1 
ATOM   751  O  O    . CYS A 1 91  ? 10.914  -32.715 -30.713 1.00 26.44  ? 91  CYS L O    1 
ATOM   752  C  CB   . CYS A 1 91  ? 10.911  -35.537 -31.690 1.00 23.73  ? 91  CYS L CB   1 
ATOM   753  S  SG   . CYS A 1 91  ? 11.902  -36.992 -32.121 1.00 26.71  ? 91  CYS L SG   1 
ATOM   754  N  N    . VAL A 1 92  ? 9.267   -33.680 -29.495 1.00 25.67  ? 92  VAL L N    1 
ATOM   755  C  CA   . VAL A 1 92  ? 8.498   -32.458 -29.331 1.00 27.49  ? 92  VAL L CA   1 
ATOM   756  C  C    . VAL A 1 92  ? 9.097   -31.648 -28.180 1.00 25.41  ? 92  VAL L C    1 
ATOM   757  O  O    . VAL A 1 92  ? 8.847   -30.460 -28.080 1.00 28.77  ? 92  VAL L O    1 
ATOM   758  C  CB   . VAL A 1 92  ? 6.989   -32.768 -29.162 1.00 33.20  ? 92  VAL L CB   1 
ATOM   759  C  CG1  . VAL A 1 92  ? 6.668   -33.634 -27.952 1.00 32.83  ? 92  VAL L CG1  1 
ATOM   760  C  CG2  . VAL A 1 92  ? 6.155   -31.502 -29.115 1.00 36.53  ? 92  VAL L CG2  1 
ATOM   761  N  N    . ASN A 1 93  ? 9.933   -32.283 -27.350 1.00 23.75  ? 93  ASN L N    1 
ATOM   762  C  CA   . ASN A 1 93  ? 10.653  -31.622 -26.273 1.00 22.97  ? 93  ASN L CA   1 
ATOM   763  C  C    . ASN A 1 93  ? 12.066  -31.190 -26.706 1.00 23.53  ? 93  ASN L C    1 
ATOM   764  O  O    . ASN A 1 93  ? 13.030  -31.940 -26.546 1.00 23.56  ? 93  ASN L O    1 
ATOM   765  C  CB   . ASN A 1 93  ? 10.717  -32.544 -25.059 1.00 20.68  ? 93  ASN L CB   1 
ATOM   766  C  CG   . ASN A 1 93  ? 11.364  -31.903 -23.856 1.00 20.88  ? 93  ASN L CG   1 
ATOM   767  O  OD1  . ASN A 1 93  ? 11.473  -30.674 -23.731 1.00 21.37  ? 93  ASN L OD1  1 
ATOM   768  N  ND2  . ASN A 1 93  ? 11.782  -32.757 -22.947 1.00 20.90  ? 93  ASN L ND2  1 
ATOM   769  N  N    . GLU A 1 94  ? 12.188  -29.943 -27.192 1.00 23.42  ? 94  GLU L N    1 
ATOM   770  C  CA   . GLU A 1 94  ? 13.445  -29.353 -27.642 1.00 24.05  ? 94  GLU L CA   1 
ATOM   771  C  C    . GLU A 1 94  ? 14.109  -30.303 -28.626 1.00 23.15  ? 94  GLU L C    1 
ATOM   772  O  O    . GLU A 1 94  ? 15.280  -30.662 -28.498 1.00 21.93  ? 94  GLU L O    1 
ATOM   773  C  CB   . GLU A 1 94  ? 14.364  -28.974 -26.474 1.00 25.63  ? 94  GLU L CB   1 
ATOM   774  C  CG   . GLU A 1 94  ? 13.768  -27.859 -25.612 1.00 28.47  ? 94  GLU L CG   1 
ATOM   775  C  CD   . GLU A 1 94  ? 13.697  -26.482 -26.263 1.00 29.90  ? 94  GLU L CD   1 
ATOM   776  O  OE1  . GLU A 1 94  ? 14.708  -25.792 -26.228 1.00 36.92  ? 94  GLU L OE1  1 
ATOM   777  O  OE2  . GLU A 1 94  ? 12.658  -26.120 -26.829 1.00 26.97  ? 94  GLU L OE2  1 
ATOM   778  N  N    . ASN A 1 95  ? 13.287  -30.766 -29.564 1.00 22.01  ? 95  ASN L N    1 
ATOM   779  C  CA   . ASN A 1 95  ? 13.773  -31.544 -30.674 1.00 21.44  ? 95  ASN L CA   1 
ATOM   780  C  C    . ASN A 1 95  ? 14.543  -32.773 -30.202 1.00 22.45  ? 95  ASN L C    1 
ATOM   781  O  O    . ASN A 1 95  ? 15.336  -33.310 -30.964 1.00 24.42  ? 95  ASN L O    1 
ATOM   782  C  CB   . ASN A 1 95  ? 14.645  -30.661 -31.554 1.00 19.70  ? 95  ASN L CB   1 
ATOM   783  C  CG   . ASN A 1 95  ? 14.759  -31.191 -32.954 1.00 17.25  ? 95  ASN L CG   1 
ATOM   784  O  OD1  . ASN A 1 95  ? 13.753  -31.514 -33.587 1.00 16.06  ? 95  ASN L OD1  1 
ATOM   785  N  ND2  . ASN A 1 95  ? 15.986  -31.277 -33.420 1.00 16.26  ? 95  ASN L ND2  1 
ATOM   786  N  N    . GLY A 1 96  ? 14.281  -33.231 -28.973 1.00 23.36  ? 96  GLY L N    1 
ATOM   787  C  CA   . GLY A 1 96  ? 14.866  -34.468 -28.477 1.00 25.05  ? 96  GLY L CA   1 
ATOM   788  C  C    . GLY A 1 96  ? 16.337  -34.324 -28.083 1.00 25.40  ? 96  GLY L C    1 
ATOM   789  O  O    . GLY A 1 96  ? 17.041  -35.309 -27.926 1.00 25.40  ? 96  GLY L O    1 
ATOM   790  N  N    . GLY A 1 97  ? 16.808  -33.090 -27.920 1.00 26.85  ? 97  GLY L N    1 
ATOM   791  C  CA   . GLY A 1 97  ? 18.241  -32.852 -27.857 1.00 27.43  ? 97  GLY L CA   1 
ATOM   792  C  C    . GLY A 1 97  ? 18.952  -33.118 -29.192 1.00 25.54  ? 97  GLY L C    1 
ATOM   793  O  O    . GLY A 1 97  ? 20.166  -33.030 -29.246 1.00 23.73  ? 97  GLY L O    1 
ATOM   794  N  N    . CYS A 1 98  ? 18.226  -33.426 -30.279 1.00 26.01  ? 98  CYS L N    1 
ATOM   795  C  CA   . CYS A 1 98  ? 18.882  -33.583 -31.571 1.00 25.86  ? 98  CYS L CA   1 
ATOM   796  C  C    . CYS A 1 98  ? 19.281  -32.212 -32.105 1.00 25.07  ? 98  CYS L C    1 
ATOM   797  O  O    . CYS A 1 98  ? 18.582  -31.226 -31.893 1.00 29.23  ? 98  CYS L O    1 
ATOM   798  C  CB   . CYS A 1 98  ? 18.010  -34.296 -32.594 1.00 25.29  ? 98  CYS L CB   1 
ATOM   799  S  SG   . CYS A 1 98  ? 17.432  -35.914 -32.032 1.00 26.93  ? 98  CYS L SG   1 
ATOM   800  N  N    . GLU A 1 99  ? 20.434  -32.162 -32.769 1.00 25.87  ? 99  GLU L N    1 
ATOM   801  C  CA   . GLU A 1 99  ? 20.953  -30.944 -33.340 1.00 25.22  ? 99  GLU L CA   1 
ATOM   802  C  C    . GLU A 1 99  ? 20.236  -30.642 -34.644 1.00 23.33  ? 99  GLU L C    1 
ATOM   803  O  O    . GLU A 1 99  ? 19.973  -29.479 -34.911 1.00 23.43  ? 99  GLU L O    1 
ATOM   804  C  CB   . GLU A 1 99  ? 22.439  -31.087 -33.603 1.00 30.39  ? 99  GLU L CB   1 
ATOM   805  C  CG   . GLU A 1 99  ? 23.042  -29.844 -34.221 1.00 35.92  ? 99  GLU L CG   1 
ATOM   806  C  CD   . GLU A 1 99  ? 24.555  -29.882 -34.332 1.00 38.03  ? 99  GLU L CD   1 
ATOM   807  O  OE1  . GLU A 1 99  ? 25.212  -30.038 -33.266 1.00 33.19  ? 99  GLU L OE1  1 
ATOM   808  O  OE2  . GLU A 1 99  ? 25.057  -29.749 -35.487 1.00 43.03  ? 99  GLU L OE2  1 
ATOM   809  N  N    . GLN A 1 100 ? 19.919  -31.689 -35.419 1.00 22.71  ? 100 GLN L N    1 
ATOM   810  C  CA   . GLN A 1 100 ? 19.163  -31.556 -36.657 1.00 22.21  ? 100 GLN L CA   1 
ATOM   811  C  C    . GLN A 1 100 ? 17.825  -32.291 -36.535 1.00 22.50  ? 100 GLN L C    1 
ATOM   812  O  O    . GLN A 1 100 ? 16.901  -31.758 -35.909 1.00 23.90  ? 100 GLN L O    1 
ATOM   813  C  CB   . GLN A 1 100 ? 20.006  -32.018 -37.847 1.00 20.82  ? 100 GLN L CB   1 
ATOM   814  C  CG   . GLN A 1 100 ? 21.187  -31.106 -38.107 1.00 20.62  ? 100 GLN L CG   1 
ATOM   815  C  CD   . GLN A 1 100 ? 21.909  -31.347 -39.413 1.00 19.66  ? 100 GLN L CD   1 
ATOM   816  O  OE1  . GLN A 1 100 ? 21.529  -32.171 -40.236 1.00 23.41  ? 100 GLN L OE1  1 
ATOM   817  N  NE2  . GLN A 1 100 ? 22.978  -30.608 -39.620 1.00 18.67  ? 100 GLN L NE2  1 
ATOM   818  N  N    . TYR A 1 101 ? 17.706  -33.483 -37.147 1.00 21.15  ? 101 TYR L N    1 
ATOM   819  C  CA   . TYR A 1 101 ? 16.430  -34.186 -37.218 1.00 23.78  ? 101 TYR L CA   1 
ATOM   820  C  C    . TYR A 1 101 ? 16.245  -35.150 -36.041 1.00 25.65  ? 101 TYR L C    1 
ATOM   821  O  O    . TYR A 1 101 ? 17.187  -35.808 -35.603 1.00 28.14  ? 101 TYR L O    1 
ATOM   822  C  CB   . TYR A 1 101 ? 16.259  -34.965 -38.531 1.00 23.95  ? 101 TYR L CB   1 
ATOM   823  C  CG   . TYR A 1 101 ? 16.285  -34.100 -39.774 1.00 22.87  ? 101 TYR L CG   1 
ATOM   824  C  CD1  . TYR A 1 101 ? 15.969  -32.753 -39.717 1.00 25.50  ? 101 TYR L CD1  1 
ATOM   825  C  CD2  . TYR A 1 101 ? 16.709  -34.612 -40.984 1.00 26.99  ? 101 TYR L CD2  1 
ATOM   826  C  CE1  . TYR A 1 101 ? 16.060  -31.940 -40.831 1.00 28.08  ? 101 TYR L CE1  1 
ATOM   827  C  CE2  . TYR A 1 101 ? 16.780  -33.819 -42.122 1.00 29.05  ? 101 TYR L CE2  1 
ATOM   828  C  CZ   . TYR A 1 101 ? 16.463  -32.474 -42.042 1.00 27.92  ? 101 TYR L CZ   1 
ATOM   829  O  OH   . TYR A 1 101 ? 16.545  -31.658 -43.127 1.00 26.13  ? 101 TYR L OH   1 
ATOM   830  N  N    . CYS A 1 102 ? 14.993  -35.253 -35.568 1.00 26.39  ? 102 CYS L N    1 
ATOM   831  C  CA   . CYS A 1 102 ? 14.608  -36.140 -34.481 1.00 25.52  ? 102 CYS L CA   1 
ATOM   832  C  C    . CYS A 1 102 ? 13.564  -37.148 -34.952 1.00 27.01  ? 102 CYS L C    1 
ATOM   833  O  O    . CYS A 1 102 ? 12.616  -36.772 -35.611 1.00 26.51  ? 102 CYS L O    1 
ATOM   834  C  CB   . CYS A 1 102 ? 14.010  -35.334 -33.347 1.00 25.36  ? 102 CYS L CB   1 
ATOM   835  S  SG   . CYS A 1 102 ? 13.737  -36.312 -31.849 1.00 26.30  ? 102 CYS L SG   1 
ATOM   836  N  N    . SER A 1 103 ? 13.726  -38.425 -34.602 1.00 30.78  ? 103 SER L N    1 
ATOM   837  C  CA   . SER A 1 103 ? 12.728  -39.435 -34.926 1.00 33.31  ? 103 SER L CA   1 
ATOM   838  C  C    . SER A 1 103 ? 12.212  -40.117 -33.652 1.00 32.01  ? 103 SER L C    1 
ATOM   839  O  O    . SER A 1 103 ? 12.991  -40.731 -32.929 1.00 32.08  ? 103 SER L O    1 
ATOM   840  C  CB   . SER A 1 103 ? 13.298  -40.440 -35.901 1.00 34.99  ? 103 SER L CB   1 
ATOM   841  O  OG   . SER A 1 103 ? 13.069  -40.042 -37.243 1.00 34.68  ? 103 SER L OG   1 
ATOM   842  N  N    . ASP A 1 104 ? 10.897  -40.004 -33.401 1.00 32.72  ? 104 ASP L N    1 
ATOM   843  C  CA   . ASP A 1 104 ? 10.224  -40.696 -32.309 1.00 38.31  ? 104 ASP L CA   1 
ATOM   844  C  C    . ASP A 1 104 ? 9.924   -42.156 -32.648 1.00 43.29  ? 104 ASP L C    1 
ATOM   845  O  O    . ASP A 1 104 ? 9.481   -42.473 -33.743 1.00 40.69  ? 104 ASP L O    1 
ATOM   846  C  CB   . ASP A 1 104 ? 8.881   -40.056 -31.958 1.00 38.62  ? 104 ASP L CB   1 
ATOM   847  C  CG   . ASP A 1 104 ? 9.013   -38.874 -31.024 1.00 37.98  ? 104 ASP L CG   1 
ATOM   848  O  OD1  . ASP A 1 104 ? 9.782   -38.999 -30.035 1.00 38.88  ? 104 ASP L OD1  1 
ATOM   849  O  OD2  . ASP A 1 104 ? 8.333   -37.846 -31.288 1.00 37.92  ? 104 ASP L OD2  1 
ATOM   850  N  N    . HIS A 1 105 ? 10.140  -43.043 -31.670 1.00 52.82  ? 105 HIS L N    1 
ATOM   851  C  CA   . HIS A 1 105 ? 9.834   -44.457 -31.814 1.00 55.62  ? 105 HIS L CA   1 
ATOM   852  C  C    . HIS A 1 105 ? 9.129   -44.917 -30.542 1.00 61.41  ? 105 HIS L C    1 
ATOM   853  O  O    . HIS A 1 105 ? 9.719   -44.897 -29.460 1.00 63.41  ? 105 HIS L O    1 
ATOM   854  C  CB   . HIS A 1 105 ? 11.095  -45.321 -31.999 1.00 53.04  ? 105 HIS L CB   1 
ATOM   855  C  CG   . HIS A 1 105 ? 12.021  -44.985 -33.140 1.00 57.72  ? 105 HIS L CG   1 
ATOM   856  N  ND1  . HIS A 1 105 ? 11.636  -44.694 -34.438 1.00 57.46  ? 105 HIS L ND1  1 
ATOM   857  C  CD2  . HIS A 1 105 ? 13.371  -44.922 -33.131 1.00 52.27  ? 105 HIS L CD2  1 
ATOM   858  C  CE1  . HIS A 1 105 ? 12.716  -44.459 -35.175 1.00 58.06  ? 105 HIS L CE1  1 
ATOM   859  N  NE2  . HIS A 1 105 ? 13.780  -44.596 -34.399 1.00 57.31  ? 105 HIS L NE2  1 
ATOM   860  N  N    . THR A 1 106 ? 7.868   -45.336 -30.679 1.00 67.30  ? 106 THR L N    1 
ATOM   861  C  CA   . THR A 1 106 ? 7.216   -46.118 -29.640 1.00 64.60  ? 106 THR L CA   1 
ATOM   862  C  C    . THR A 1 106 ? 8.008   -47.415 -29.451 1.00 62.75  ? 106 THR L C    1 
ATOM   863  O  O    . THR A 1 106 ? 8.474   -48.026 -30.420 1.00 50.97  ? 106 THR L O    1 
ATOM   864  C  CB   . THR A 1 106 ? 5.740   -46.383 -29.971 1.00 65.15  ? 106 THR L CB   1 
ATOM   865  O  OG1  . THR A 1 106 ? 5.632   -47.321 -31.045 1.00 62.30  ? 106 THR L OG1  1 
ATOM   866  C  CG2  . THR A 1 106 ? 4.991   -45.122 -30.343 1.00 66.29  ? 106 THR L CG2  1 
ATOM   867  N  N    . GLY A 1 107 ? 8.193   -47.801 -28.184 1.00 62.51  ? 107 GLY L N    1 
ATOM   868  C  CA   . GLY A 1 107 ? 8.882   -49.037 -27.845 1.00 65.73  ? 107 GLY L CA   1 
ATOM   869  C  C    . GLY A 1 107 ? 10.332  -48.789 -27.440 1.00 64.70  ? 107 GLY L C    1 
ATOM   870  O  O    . GLY A 1 107 ? 10.934  -49.557 -26.692 1.00 63.73  ? 107 GLY L O    1 
ATOM   871  N  N    . THR A 1 108 ? 10.890  -47.686 -27.929 1.00 63.46  ? 108 THR L N    1 
ATOM   872  C  CA   . THR A 1 108 ? 12.314  -47.477 -27.801 1.00 60.30  ? 108 THR L CA   1 
ATOM   873  C  C    . THR A 1 108 ? 12.598  -45.980 -27.698 1.00 59.38  ? 108 THR L C    1 
ATOM   874  O  O    . THR A 1 108 ? 11.704  -45.142 -27.793 1.00 57.22  ? 108 THR L O    1 
ATOM   875  C  CB   . THR A 1 108 ? 13.020  -48.229 -28.935 1.00 53.95  ? 108 THR L CB   1 
ATOM   876  O  OG1  . THR A 1 108 ? 14.398  -48.251 -28.578 1.00 54.24  ? 108 THR L OG1  1 
ATOM   877  C  CG2  . THR A 1 108 ? 12.815  -47.611 -30.299 1.00 54.22  ? 108 THR L CG2  1 
ATOM   878  N  N    . LYS A 1 109 ? 13.877  -45.676 -27.493 1.00 57.41  ? 109 LYS L N    1 
ATOM   879  C  CA   . LYS A 1 109 ? 14.392  -44.320 -27.411 1.00 57.06  ? 109 LYS L CA   1 
ATOM   880  C  C    . LYS A 1 109 ? 14.293  -43.592 -28.763 1.00 52.64  ? 109 LYS L C    1 
ATOM   881  O  O    . LYS A 1 109 ? 14.395  -44.200 -29.835 1.00 46.86  ? 109 LYS L O    1 
ATOM   882  C  CB   . LYS A 1 109 ? 15.855  -44.410 -26.965 1.00 56.79  ? 109 LYS L CB   1 
ATOM   883  C  CG   . LYS A 1 109 ? 16.368  -43.252 -26.128 1.00 61.61  ? 109 LYS L CG   1 
ATOM   884  C  CD   . LYS A 1 109 ? 17.827  -42.946 -26.383 1.00 66.79  ? 109 LYS L CD   1 
ATOM   885  C  CE   . LYS A 1 109 ? 18.770  -44.063 -25.994 1.00 69.23  ? 109 LYS L CE   1 
ATOM   886  N  NZ   . LYS A 1 109 ? 18.953  -44.128 -24.524 1.00 70.56  ? 109 LYS L NZ   1 
ATOM   887  N  N    . ARG A 1 110 ? 14.136  -42.259 -28.689 1.00 46.57  ? 110 ARG L N    1 
ATOM   888  C  CA   . ARG A 1 110 ? 14.229  -41.384 -29.851 1.00 42.46  ? 110 ARG L CA   1 
ATOM   889  C  C    . ARG A 1 110 ? 15.632  -41.488 -30.450 1.00 40.57  ? 110 ARG L C    1 
ATOM   890  O  O    . ARG A 1 110 ? 16.618  -41.582 -29.720 1.00 36.46  ? 110 ARG L O    1 
ATOM   891  C  CB   . ARG A 1 110 ? 13.911  -39.929 -29.480 1.00 34.67  ? 110 ARG L CB   1 
ATOM   892  C  CG   . ARG A 1 110 ? 14.991  -39.219 -28.671 1.00 31.92  ? 110 ARG L CG   1 
ATOM   893  C  CD   . ARG A 1 110 ? 15.968  -38.427 -29.523 1.00 29.37  ? 110 ARG L CD   1 
ATOM   894  N  NE   . ARG A 1 110 ? 17.055  -37.841 -28.752 1.00 28.01  ? 110 ARG L NE   1 
ATOM   895  C  CZ   . ARG A 1 110 ? 18.116  -38.493 -28.266 1.00 33.18  ? 110 ARG L CZ   1 
ATOM   896  N  NH1  . ARG A 1 110 ? 18.307  -39.771 -28.549 1.00 35.56  ? 110 ARG L NH1  1 
ATOM   897  N  NH2  . ARG A 1 110 ? 19.003  -37.862 -27.503 1.00 32.63  ? 110 ARG L NH2  1 
ATOM   898  N  N    . SER A 1 111 ? 15.691  -41.455 -31.782 1.00 37.69  ? 111 SER L N    1 
ATOM   899  C  CA   . SER A 1 111 ? 16.945  -41.477 -32.513 1.00 40.68  ? 111 SER L CA   1 
ATOM   900  C  C    . SER A 1 111 ? 17.064  -40.170 -33.286 1.00 38.34  ? 111 SER L C    1 
ATOM   901  O  O    . SER A 1 111 ? 16.068  -39.688 -33.823 1.00 36.18  ? 111 SER L O    1 
ATOM   902  C  CB   . SER A 1 111 ? 16.999  -42.662 -33.448 1.00 42.83  ? 111 SER L CB   1 
ATOM   903  O  OG   . SER A 1 111 ? 15.936  -42.602 -34.392 1.00 44.45  ? 111 SER L OG   1 
ATOM   904  N  N    . CYS A 1 112 ? 18.280  -39.613 -33.306 1.00 36.64  ? 112 CYS L N    1 
ATOM   905  C  CA   . CYS A 1 112 ? 18.589  -38.410 -34.058 1.00 34.50  ? 112 CYS L CA   1 
ATOM   906  C  C    . CYS A 1 112 ? 19.146  -38.762 -35.440 1.00 35.38  ? 112 CYS L C    1 
ATOM   907  O  O    . CYS A 1 112 ? 19.808  -39.786 -35.593 1.00 36.56  ? 112 CYS L O    1 
ATOM   908  C  CB   . CYS A 1 112 ? 19.648  -37.600 -33.340 1.00 31.57  ? 112 CYS L CB   1 
ATOM   909  S  SG   . CYS A 1 112 ? 19.113  -36.994 -31.729 1.00 30.62  ? 112 CYS L SG   1 
ATOM   910  N  N    . ARG A 1 113 ? 18.900  -37.878 -36.420 1.00 34.94  ? 113 ARG L N    1 
ATOM   911  C  CA   . ARG A 1 113 ? 19.451  -37.992 -37.765 1.00 36.97  ? 113 ARG L CA   1 
ATOM   912  C  C    . ARG A 1 113 ? 20.087  -36.658 -38.188 1.00 35.21  ? 113 ARG L C    1 
ATOM   913  O  O    . ARG A 1 113 ? 20.042  -35.686 -37.434 1.00 34.03  ? 113 ARG L O    1 
ATOM   914  C  CB   . ARG A 1 113 ? 18.345  -38.414 -38.743 1.00 36.65  ? 113 ARG L CB   1 
ATOM   915  C  CG   . ARG A 1 113 ? 17.776  -39.796 -38.467 1.00 40.88  ? 113 ARG L CG   1 
ATOM   916  C  CD   . ARG A 1 113 ? 16.537  -40.083 -39.299 1.00 43.98  ? 113 ARG L CD   1 
ATOM   917  N  NE   . ARG A 1 113 ? 15.422  -39.205 -38.953 1.00 42.41  ? 113 ARG L NE   1 
ATOM   918  C  CZ   . ARG A 1 113 ? 14.848  -38.333 -39.773 1.00 41.39  ? 113 ARG L CZ   1 
ATOM   919  N  NH1  . ARG A 1 113 ? 15.389  -38.066 -40.949 1.00 37.46  ? 113 ARG L NH1  1 
ATOM   920  N  NH2  . ARG A 1 113 ? 13.748  -37.702 -39.392 1.00 42.59  ? 113 ARG L NH2  1 
ATOM   921  N  N    . CYS A 1 114 ? 20.692  -36.638 -39.395 1.00 32.24  ? 114 CYS L N    1 
ATOM   922  C  CA   . CYS A 1 114 ? 21.256  -35.441 -39.991 1.00 27.06  ? 114 CYS L CA   1 
ATOM   923  C  C    . CYS A 1 114 ? 20.826  -35.272 -41.448 1.00 28.19  ? 114 CYS L C    1 
ATOM   924  O  O    . CYS A 1 114 ? 20.569  -36.262 -42.150 1.00 27.04  ? 114 CYS L O    1 
ATOM   925  C  CB   . CYS A 1 114 ? 22.773  -35.489 -39.993 1.00 25.69  ? 114 CYS L CB   1 
ATOM   926  S  SG   . CYS A 1 114 ? 23.527  -35.689 -38.367 1.00 23.39  ? 114 CYS L SG   1 
ATOM   927  N  N    . HIS A 1 115 ? 20.838  -33.994 -41.904 1.00 29.00  ? 115 HIS L N    1 
ATOM   928  C  CA   . HIS A 1 115 ? 20.600  -33.613 -43.301 1.00 26.23  ? 115 HIS L CA   1 
ATOM   929  C  C    . HIS A 1 115 ? 21.662  -34.234 -44.231 1.00 25.40  ? 115 HIS L C    1 
ATOM   930  O  O    . HIS A 1 115 ? 22.801  -34.503 -43.838 1.00 24.52  ? 115 HIS L O    1 
ATOM   931  C  CB   . HIS A 1 115 ? 20.507  -32.078 -43.407 1.00 22.90  ? 115 HIS L CB   1 
ATOM   932  C  CG   . HIS A 1 115 ? 19.967  -31.538 -44.702 1.00 22.86  ? 115 HIS L CG   1 
ATOM   933  N  ND1  . HIS A 1 115 ? 20.715  -31.490 -45.860 1.00 22.27  ? 115 HIS L ND1  1 
ATOM   934  C  CD2  . HIS A 1 115 ? 18.764  -31.020 -45.030 1.00 21.73  ? 115 HIS L CD2  1 
ATOM   935  C  CE1  . HIS A 1 115 ? 19.982  -30.980 -46.845 1.00 23.55  ? 115 HIS L CE1  1 
ATOM   936  N  NE2  . HIS A 1 115 ? 18.800  -30.673 -46.363 1.00 22.77  ? 115 HIS L NE2  1 
ATOM   937  N  N    . GLU A 1 116 ? 21.297  -34.441 -45.494 1.00 26.89  ? 116 GLU L N    1 
ATOM   938  C  CA   . GLU A 1 116 ? 22.289  -34.711 -46.526 1.00 30.75  ? 116 GLU L CA   1 
ATOM   939  C  C    . GLU A 1 116 ? 23.472  -33.764 -46.308 1.00 28.40  ? 116 GLU L C    1 
ATOM   940  O  O    . GLU A 1 116 ? 23.298  -32.567 -46.055 1.00 25.22  ? 116 GLU L O    1 
ATOM   941  C  CB   . GLU A 1 116 ? 21.722  -34.541 -47.940 1.00 35.92  ? 116 GLU L CB   1 
ATOM   942  C  CG   . GLU A 1 116 ? 20.349  -35.169 -48.144 1.00 46.06  ? 116 GLU L CG   1 
ATOM   943  C  CD   . GLU A 1 116 ? 19.134  -34.279 -47.861 1.00 52.36  ? 116 GLU L CD   1 
ATOM   944  O  OE1  . GLU A 1 116 ? 18.579  -34.357 -46.726 1.00 42.06  ? 116 GLU L OE1  1 
ATOM   945  O  OE2  . GLU A 1 116 ? 18.695  -33.541 -48.799 1.00 57.90  ? 116 GLU L OE2  1 
ATOM   946  N  N    . GLY A 1 117 ? 24.682  -34.331 -46.348 1.00 28.36  ? 117 GLY L N    1 
ATOM   947  C  CA   . GLY A 1 117 ? 25.911  -33.550 -46.275 1.00 27.34  ? 117 GLY L CA   1 
ATOM   948  C  C    . GLY A 1 117 ? 26.482  -33.501 -44.868 1.00 25.19  ? 117 GLY L C    1 
ATOM   949  O  O    . GLY A 1 117 ? 27.545  -32.946 -44.648 1.00 27.13  ? 117 GLY L O    1 
ATOM   950  N  N    . TYR A 1 118 ? 25.761  -34.081 -43.916 1.00 25.81  ? 118 TYR L N    1 
ATOM   951  C  CA   . TYR A 1 118 ? 26.259  -34.232 -42.565 1.00 26.15  ? 118 TYR L CA   1 
ATOM   952  C  C    . TYR A 1 118 ? 26.095  -35.690 -42.159 1.00 28.39  ? 118 TYR L C    1 
ATOM   953  O  O    . TYR A 1 118 ? 25.247  -36.405 -42.701 1.00 26.20  ? 118 TYR L O    1 
ATOM   954  C  CB   . TYR A 1 118 ? 25.472  -33.375 -41.565 1.00 23.70  ? 118 TYR L CB   1 
ATOM   955  C  CG   . TYR A 1 118 ? 25.413  -31.891 -41.879 1.00 21.95  ? 118 TYR L CG   1 
ATOM   956  C  CD1  . TYR A 1 118 ? 26.068  -30.985 -41.072 1.00 21.31  ? 118 TYR L CD1  1 
ATOM   957  C  CD2  . TYR A 1 118 ? 24.617  -31.383 -42.894 1.00 22.18  ? 118 TYR L CD2  1 
ATOM   958  C  CE1  . TYR A 1 118 ? 26.002  -29.628 -41.304 1.00 20.70  ? 118 TYR L CE1  1 
ATOM   959  C  CE2  . TYR A 1 118 ? 24.542  -30.020 -43.129 1.00 22.02  ? 118 TYR L CE2  1 
ATOM   960  C  CZ   . TYR A 1 118 ? 25.270  -29.141 -42.354 1.00 20.54  ? 118 TYR L CZ   1 
ATOM   961  O  OH   . TYR A 1 118 ? 25.297  -27.783 -42.541 1.00 20.49  ? 118 TYR L OH   1 
ATOM   962  N  N    . SER A 1 119 ? 26.859  -36.087 -41.140 1.00 30.44  ? 119 SER L N    1 
ATOM   963  C  CA   . SER A 1 119 ? 26.636  -37.374 -40.508 1.00 33.63  ? 119 SER L CA   1 
ATOM   964  C  C    . SER A 1 119 ? 26.703  -37.210 -38.998 1.00 32.78  ? 119 SER L C    1 
ATOM   965  O  O    . SER A 1 119 ? 27.266  -36.254 -38.476 1.00 34.95  ? 119 SER L O    1 
ATOM   966  C  CB   . SER A 1 119 ? 27.612  -38.431 -40.993 1.00 35.56  ? 119 SER L CB   1 
ATOM   967  O  OG   . SER A 1 119 ? 28.889  -38.230 -40.416 1.00 34.02  ? 119 SER L OG   1 
ATOM   968  N  N    . LEU A 1 120 ? 26.126  -38.201 -38.323 1.00 36.40  ? 120 LEU L N    1 
ATOM   969  C  CA   . LEU A 1 120 ? 25.908  -38.168 -36.894 1.00 36.27  ? 120 LEU L CA   1 
ATOM   970  C  C    . LEU A 1 120 ? 27.174  -38.611 -36.168 1.00 35.72  ? 120 LEU L C    1 
ATOM   971  O  O    . LEU A 1 120 ? 27.749  -39.639 -36.499 1.00 39.14  ? 120 LEU L O    1 
ATOM   972  C  CB   . LEU A 1 120 ? 24.725  -39.098 -36.601 1.00 38.06  ? 120 LEU L CB   1 
ATOM   973  C  CG   . LEU A 1 120 ? 24.100  -38.914 -35.222 1.00 41.87  ? 120 LEU L CG   1 
ATOM   974  C  CD1  . LEU A 1 120 ? 23.297  -37.613 -35.176 1.00 41.30  ? 120 LEU L CD1  1 
ATOM   975  C  CD2  . LEU A 1 120 ? 23.243  -40.122 -34.847 1.00 41.58  ? 120 LEU L CD2  1 
ATOM   976  N  N    . LEU A 1 121 ? 27.581  -37.830 -35.165 1.00 37.87  ? 121 LEU L N    1 
ATOM   977  C  CA   . LEU A 1 121 ? 28.691  -38.165 -34.282 1.00 41.22  ? 121 LEU L CA   1 
ATOM   978  C  C    . LEU A 1 121 ? 28.305  -39.251 -33.271 1.00 50.51  ? 121 LEU L C    1 
ATOM   979  O  O    . LEU A 1 121 ? 27.193  -39.779 -33.288 1.00 55.73  ? 121 LEU L O    1 
ATOM   980  C  CB   . LEU A 1 121 ? 29.113  -36.890 -33.555 1.00 35.34  ? 121 LEU L CB   1 
ATOM   981  C  CG   . LEU A 1 121 ? 29.658  -35.782 -34.450 1.00 32.78  ? 121 LEU L CG   1 
ATOM   982  C  CD1  . LEU A 1 121 ? 30.180  -34.636 -33.604 1.00 31.86  ? 121 LEU L CD1  1 
ATOM   983  C  CD2  . LEU A 1 121 ? 30.745  -36.302 -35.385 1.00 31.42  ? 121 LEU L CD2  1 
ATOM   984  N  N    . ALA A 1 122 ? 29.246  -39.584 -32.377 1.00 52.90  ? 122 ALA L N    1 
ATOM   985  C  CA   . ALA A 1 122 ? 29.105  -40.771 -31.550 1.00 56.62  ? 122 ALA L CA   1 
ATOM   986  C  C    . ALA A 1 122 ? 28.155  -40.489 -30.387 1.00 53.85  ? 122 ALA L C    1 
ATOM   987  O  O    . ALA A 1 122 ? 27.352  -41.365 -30.040 1.00 56.29  ? 122 ALA L O    1 
ATOM   988  C  CB   . ALA A 1 122 ? 30.460  -41.251 -31.079 1.00 55.27  ? 122 ALA L CB   1 
ATOM   989  N  N    . ASP A 1 123 ? 28.232  -39.258 -29.844 1.00 44.16  ? 123 ASP L N    1 
ATOM   990  C  CA   . ASP A 1 123 ? 27.339  -38.776 -28.795 1.00 39.07  ? 123 ASP L CA   1 
ATOM   991  C  C    . ASP A 1 123 ? 25.855  -38.876 -29.160 1.00 36.22  ? 123 ASP L C    1 
ATOM   992  O  O    . ASP A 1 123 ? 25.012  -38.637 -28.302 1.00 38.68  ? 123 ASP L O    1 
ATOM   993  C  CB   . ASP A 1 123 ? 27.605  -37.313 -28.434 1.00 38.86  ? 123 ASP L CB   1 
ATOM   994  C  CG   . ASP A 1 123 ? 27.339  -36.317 -29.551 1.00 38.84  ? 123 ASP L CG   1 
ATOM   995  O  OD1  . ASP A 1 123 ? 26.996  -36.768 -30.684 1.00 38.68  ? 123 ASP L OD1  1 
ATOM   996  O  OD2  . ASP A 1 123 ? 27.490  -35.094 -29.283 1.00 30.40  ? 123 ASP L OD2  1 
ATOM   997  N  N    . GLY A 1 124 ? 25.531  -39.144 -30.431 1.00 36.06  ? 124 GLY L N    1 
ATOM   998  C  CA   . GLY A 1 124 ? 24.203  -39.591 -30.818 1.00 35.51  ? 124 GLY L CA   1 
ATOM   999  C  C    . GLY A 1 124 ? 23.247  -38.458 -31.204 1.00 35.03  ? 124 GLY L C    1 
ATOM   1000 O  O    . GLY A 1 124 ? 22.157  -38.741 -31.689 1.00 36.18  ? 124 GLY L O    1 
ATOM   1001 N  N    . VAL A 1 125 ? 23.660  -37.193 -31.012 1.00 33.85  ? 125 VAL L N    1 
ATOM   1002 C  CA   . VAL A 1 125 ? 22.807  -36.036 -31.273 1.00 35.70  ? 125 VAL L CA   1 
ATOM   1003 C  C    . VAL A 1 125 ? 23.431  -34.990 -32.215 1.00 35.95  ? 125 VAL L C    1 
ATOM   1004 O  O    . VAL A 1 125 ? 22.701  -34.205 -32.821 1.00 31.96  ? 125 VAL L O    1 
ATOM   1005 C  CB   . VAL A 1 125 ? 22.431  -35.393 -29.934 1.00 33.44  ? 125 VAL L CB   1 
ATOM   1006 C  CG1  . VAL A 1 125 ? 21.800  -36.433 -29.019 1.00 35.01  ? 125 VAL L CG1  1 
ATOM   1007 C  CG2  . VAL A 1 125 ? 23.618  -34.712 -29.276 1.00 31.31  ? 125 VAL L CG2  1 
ATOM   1008 N  N    . SER A 1 126 ? 24.773  -34.935 -32.293 1.00 38.79  ? 126 SER L N    1 
ATOM   1009 C  CA   . SER A 1 126 ? 25.492  -33.888 -33.012 1.00 36.54  ? 126 SER L CA   1 
ATOM   1010 C  C    . SER A 1 126 ? 25.696  -34.287 -34.462 1.00 32.95  ? 126 SER L C    1 
ATOM   1011 O  O    . SER A 1 126 ? 25.875  -35.453 -34.735 1.00 32.24  ? 126 SER L O    1 
ATOM   1012 C  CB   . SER A 1 126 ? 26.813  -33.588 -32.368 1.00 35.65  ? 126 SER L CB   1 
ATOM   1013 O  OG   . SER A 1 126 ? 26.632  -32.698 -31.284 1.00 38.72  ? 126 SER L OG   1 
ATOM   1014 N  N    . CYS A 1 127 ? 25.660  -33.305 -35.373 1.00 36.94  ? 127 CYS L N    1 
ATOM   1015 C  CA   . CYS A 1 127 ? 25.914  -33.538 -36.790 1.00 34.74  ? 127 CYS L CA   1 
ATOM   1016 C  C    . CYS A 1 127 ? 27.184  -32.793 -37.202 1.00 36.93  ? 127 CYS L C    1 
ATOM   1017 O  O    . CYS A 1 127 ? 27.451  -31.706 -36.668 1.00 33.75  ? 127 CYS L O    1 
ATOM   1018 C  CB   . CYS A 1 127 ? 24.740  -33.057 -37.625 1.00 30.15  ? 127 CYS L CB   1 
ATOM   1019 S  SG   . CYS A 1 127 ? 23.227  -34.008 -37.338 1.00 25.91  ? 127 CYS L SG   1 
ATOM   1020 N  N    . THR A 1 128 ? 27.956  -33.392 -38.128 1.00 32.26  ? 128 THR L N    1 
ATOM   1021 C  CA   . THR A 1 128 ? 29.181  -32.779 -38.629 1.00 30.87  ? 128 THR L CA   1 
ATOM   1022 C  C    . THR A 1 128 ? 29.212  -32.886 -40.156 1.00 28.47  ? 128 THR L C    1 
ATOM   1023 O  O    . THR A 1 128 ? 28.749  -33.873 -40.735 1.00 27.16  ? 128 THR L O    1 
ATOM   1024 C  CB   . THR A 1 128 ? 30.404  -33.412 -37.943 1.00 31.03  ? 128 THR L CB   1 
ATOM   1025 O  OG1  . THR A 1 128 ? 31.451  -32.453 -37.790 1.00 28.18  ? 128 THR L OG1  1 
ATOM   1026 C  CG2  . THR A 1 128 ? 30.928  -34.634 -38.671 1.00 31.04  ? 128 THR L CG2  1 
ATOM   1027 N  N    . PRO A 1 129 ? 29.748  -31.874 -40.875 1.00 30.91  ? 129 PRO L N    1 
ATOM   1028 C  CA   . PRO A 1 129 ? 29.749  -31.894 -42.343 1.00 32.04  ? 129 PRO L CA   1 
ATOM   1029 C  C    . PRO A 1 129 ? 30.654  -32.984 -42.913 1.00 30.47  ? 129 PRO L C    1 
ATOM   1030 O  O    . PRO A 1 129 ? 31.770  -33.122 -42.439 1.00 29.65  ? 129 PRO L O    1 
ATOM   1031 C  CB   . PRO A 1 129 ? 30.320  -30.518 -42.747 1.00 30.84  ? 129 PRO L CB   1 
ATOM   1032 C  CG   . PRO A 1 129 ? 30.236  -29.666 -41.498 1.00 29.92  ? 129 PRO L CG   1 
ATOM   1033 C  CD   . PRO A 1 129 ? 30.345  -30.638 -40.340 1.00 31.37  ? 129 PRO L CD   1 
ATOM   1034 N  N    . THR A 1 130 ? 30.157  -33.732 -43.909 1.00 31.27  ? 130 THR L N    1 
ATOM   1035 C  CA   . THR A 1 130 ? 30.929  -34.722 -44.650 1.00 32.37  ? 130 THR L CA   1 
ATOM   1036 C  C    . THR A 1 130 ? 31.277  -34.218 -46.061 1.00 35.07  ? 130 THR L C    1 
ATOM   1037 O  O    . THR A 1 130 ? 31.630  -35.035 -46.917 1.00 33.86  ? 130 THR L O    1 
ATOM   1038 C  CB   . THR A 1 130 ? 30.123  -36.015 -44.819 1.00 32.69  ? 130 THR L CB   1 
ATOM   1039 O  OG1  . THR A 1 130 ? 28.990  -35.642 -45.599 1.00 36.18  ? 130 THR L OG1  1 
ATOM   1040 C  CG2  . THR A 1 130 ? 29.664  -36.651 -43.526 1.00 34.42  ? 130 THR L CG2  1 
ATOM   1041 N  N    . VAL A 1 131 ? 31.097  -32.900 -46.309 1.00 31.62  ? 131 VAL L N    1 
ATOM   1042 C  CA   . VAL A 1 131 ? 31.423  -32.234 -47.567 1.00 31.54  ? 131 VAL L CA   1 
ATOM   1043 C  C    . VAL A 1 131 ? 31.971  -30.852 -47.234 1.00 29.12  ? 131 VAL L C    1 
ATOM   1044 O  O    . VAL A 1 131 ? 31.929  -30.417 -46.092 1.00 27.73  ? 131 VAL L O    1 
ATOM   1045 C  CB   . VAL A 1 131 ? 30.233  -32.077 -48.550 1.00 32.98  ? 131 VAL L CB   1 
ATOM   1046 C  CG1  . VAL A 1 131 ? 29.752  -33.402 -49.149 1.00 30.68  ? 131 VAL L CG1  1 
ATOM   1047 C  CG2  . VAL A 1 131 ? 29.082  -31.290 -47.926 1.00 31.96  ? 131 VAL L CG2  1 
ATOM   1048 N  N    . GLU A 1 132 ? 32.457  -30.147 -48.253 1.00 33.65  ? 132 GLU L N    1 
ATOM   1049 C  CA   . GLU A 1 132 ? 33.229  -28.946 -48.002 1.00 37.96  ? 132 GLU L CA   1 
ATOM   1050 C  C    . GLU A 1 132 ? 32.293  -27.763 -47.818 1.00 32.39  ? 132 GLU L C    1 
ATOM   1051 O  O    . GLU A 1 132 ? 32.552  -26.927 -46.946 1.00 30.81  ? 132 GLU L O    1 
ATOM   1052 C  CB   . GLU A 1 132 ? 34.226  -28.620 -49.114 1.00 46.88  ? 132 GLU L CB   1 
ATOM   1053 C  CG   . GLU A 1 132 ? 35.423  -27.852 -48.561 1.00 60.58  ? 132 GLU L CG   1 
ATOM   1054 C  CD   . GLU A 1 132 ? 35.915  -26.646 -49.345 1.00 72.79  ? 132 GLU L CD   1 
ATOM   1055 O  OE1  . GLU A 1 132 ? 35.456  -26.457 -50.501 1.00 69.46  ? 132 GLU L OE1  1 
ATOM   1056 O  OE2  . GLU A 1 132 ? 36.791  -25.907 -48.807 1.00 72.85  ? 132 GLU L OE2  1 
ATOM   1057 N  N    . TYR A 1 133 ? 31.230  -27.722 -48.637 1.00 28.34  ? 133 TYR L N    1 
ATOM   1058 C  CA   . TYR A 1 133 ? 30.223  -26.665 -48.563 1.00 28.52  ? 133 TYR L CA   1 
ATOM   1059 C  C    . TYR A 1 133 ? 28.828  -27.253 -48.315 1.00 27.23  ? 133 TYR L C    1 
ATOM   1060 O  O    . TYR A 1 133 ? 28.021  -27.402 -49.235 1.00 26.21  ? 133 TYR L O    1 
ATOM   1061 C  CB   . TYR A 1 133 ? 30.248  -25.838 -49.851 1.00 27.74  ? 133 TYR L CB   1 
ATOM   1062 C  CG   . TYR A 1 133 ? 31.504  -25.004 -50.008 1.00 26.78  ? 133 TYR L CG   1 
ATOM   1063 C  CD1  . TYR A 1 133 ? 31.706  -23.892 -49.212 1.00 30.26  ? 133 TYR L CD1  1 
ATOM   1064 C  CD2  . TYR A 1 133 ? 32.493  -25.350 -50.915 1.00 28.15  ? 133 TYR L CD2  1 
ATOM   1065 C  CE1  . TYR A 1 133 ? 32.851  -23.121 -49.310 1.00 31.50  ? 133 TYR L CE1  1 
ATOM   1066 C  CE2  . TYR A 1 133 ? 33.646  -24.590 -51.030 1.00 31.35  ? 133 TYR L CE2  1 
ATOM   1067 C  CZ   . TYR A 1 133 ? 33.826  -23.479 -50.216 1.00 32.63  ? 133 TYR L CZ   1 
ATOM   1068 O  OH   . TYR A 1 133 ? 34.911  -22.668 -50.307 1.00 32.05  ? 133 TYR L OH   1 
ATOM   1069 N  N    . PRO A 1 134 ? 28.490  -27.625 -47.062 1.00 25.50  ? 134 PRO L N    1 
ATOM   1070 C  CA   . PRO A 1 134 ? 27.173  -28.192 -46.759 1.00 23.72  ? 134 PRO L CA   1 
ATOM   1071 C  C    . PRO A 1 134 ? 26.152  -27.069 -46.724 1.00 22.25  ? 134 PRO L C    1 
ATOM   1072 O  O    . PRO A 1 134 ? 26.524  -25.922 -46.474 1.00 21.16  ? 134 PRO L O    1 
ATOM   1073 C  CB   . PRO A 1 134 ? 27.365  -28.818 -45.370 1.00 24.78  ? 134 PRO L CB   1 
ATOM   1074 C  CG   . PRO A 1 134 ? 28.427  -27.941 -44.734 1.00 25.72  ? 134 PRO L CG   1 
ATOM   1075 C  CD   . PRO A 1 134 ? 29.354  -27.544 -45.878 1.00 24.57  ? 134 PRO L CD   1 
ATOM   1076 N  N    . CYS A 1 135 ? 24.885  -27.412 -46.998 1.00 23.24  ? 135 CYS L N    1 
ATOM   1077 C  CA   . CYS A 1 135 ? 23.775  -26.470 -46.889 1.00 20.24  ? 135 CYS L CA   1 
ATOM   1078 C  C    . CYS A 1 135 ? 23.743  -25.834 -45.509 1.00 19.03  ? 135 CYS L C    1 
ATOM   1079 O  O    . CYS A 1 135 ? 24.101  -26.453 -44.519 1.00 18.92  ? 135 CYS L O    1 
ATOM   1080 C  CB   . CYS A 1 135 ? 22.444  -27.125 -47.218 1.00 18.60  ? 135 CYS L CB   1 
ATOM   1081 S  SG   . CYS A 1 135 ? 21.874  -28.345 -46.013 1.00 18.55  ? 135 CYS L SG   1 
ATOM   1082 N  N    . GLY A 1 136 ? 23.429  -24.538 -45.486 1.00 22.06  ? 136 GLY L N    1 
ATOM   1083 C  CA   . GLY A 1 136 ? 23.048  -23.824 -44.275 1.00 22.11  ? 136 GLY L CA   1 
ATOM   1084 C  C    . GLY A 1 136 ? 24.184  -23.525 -43.302 1.00 23.78  ? 136 GLY L C    1 
ATOM   1085 O  O    . GLY A 1 136 ? 23.935  -23.363 -42.100 1.00 24.70  ? 136 GLY L O    1 
ATOM   1086 N  N    . LYS A 1 137 ? 25.412  -23.395 -43.827 1.00 25.15  ? 137 LYS L N    1 
ATOM   1087 C  CA   . LYS A 1 137 ? 26.544  -22.861 -43.076 1.00 23.39  ? 137 LYS L CA   1 
ATOM   1088 C  C    . LYS A 1 137 ? 27.121  -21.719 -43.880 1.00 21.55  ? 137 LYS L C    1 
ATOM   1089 O  O    . LYS A 1 137 ? 27.129  -21.785 -45.108 1.00 21.86  ? 137 LYS L O    1 
ATOM   1090 C  CB   . LYS A 1 137 ? 27.665  -23.890 -42.886 1.00 24.83  ? 137 LYS L CB   1 
ATOM   1091 C  CG   . LYS A 1 137 ? 27.356  -25.043 -41.945 1.00 28.45  ? 137 LYS L CG   1 
ATOM   1092 C  CD   . LYS A 1 137 ? 27.145  -24.628 -40.495 1.00 31.39  ? 137 LYS L CD   1 
ATOM   1093 C  CE   . LYS A 1 137 ? 26.744  -25.764 -39.577 1.00 32.35  ? 137 LYS L CE   1 
ATOM   1094 N  NZ   . LYS A 1 137 ? 27.772  -26.808 -39.623 1.00 38.45  ? 137 LYS L NZ   1 
ATOM   1095 N  N    . ILE A 1 138 ? 27.660  -20.725 -43.180 1.00 22.42  ? 138 ILE L N    1 
ATOM   1096 C  CA   . ILE A 1 138 ? 28.204  -19.532 -43.812 1.00 25.30  ? 138 ILE L CA   1 
ATOM   1097 C  C    . ILE A 1 138 ? 29.724  -19.638 -43.754 1.00 27.33  ? 138 ILE L C    1 
ATOM   1098 O  O    . ILE A 1 138 ? 30.303  -19.297 -42.722 1.00 29.02  ? 138 ILE L O    1 
ATOM   1099 C  CB   . ILE A 1 138 ? 27.693  -18.264 -43.091 1.00 25.24  ? 138 ILE L CB   1 
ATOM   1100 C  CG1  . ILE A 1 138 ? 26.164  -18.207 -43.096 1.00 23.87  ? 138 ILE L CG1  1 
ATOM   1101 C  CG2  . ILE A 1 138 ? 28.304  -16.979 -43.665 1.00 26.06  ? 138 ILE L CG2  1 
ATOM   1102 C  CD1  . ILE A 1 138 ? 25.620  -17.192 -42.141 1.00 25.16  ? 138 ILE L CD1  1 
ATOM   1103 N  N    . PRO A 1 139 ? 30.408  -20.098 -44.830 1.00 26.04  ? 139 PRO L N    1 
ATOM   1104 C  CA   . PRO A 1 139 ? 31.851  -20.315 -44.790 1.00 28.71  ? 139 PRO L CA   1 
ATOM   1105 C  C    . PRO A 1 139 ? 32.653  -19.120 -44.286 1.00 30.91  ? 139 PRO L C    1 
ATOM   1106 O  O    . PRO A 1 139 ? 33.611  -19.335 -43.569 1.00 40.06  ? 139 PRO L O    1 
ATOM   1107 C  CB   . PRO A 1 139 ? 32.232  -20.659 -46.234 1.00 28.18  ? 139 PRO L CB   1 
ATOM   1108 C  CG   . PRO A 1 139 ? 30.959  -21.223 -46.812 1.00 27.35  ? 139 PRO L CG   1 
ATOM   1109 C  CD   . PRO A 1 139 ? 29.846  -20.450 -46.133 1.00 26.91  ? 139 PRO L CD   1 
ATOM   1110 N  N    . ILE A 1 140 ? 32.301  -17.868 -44.592 1.00 32.94  ? 140 ILE L N    1 
ATOM   1111 C  CA   . ILE A 1 140 ? 33.261  -16.810 -44.270 1.00 40.08  ? 140 ILE L CA   1 
ATOM   1112 C  C    . ILE A 1 140 ? 33.258  -16.516 -42.782 1.00 42.07  ? 140 ILE L C    1 
ATOM   1113 O  O    . ILE A 1 140 ? 33.902  -15.553 -42.390 1.00 46.62  ? 140 ILE L O    1 
ATOM   1114 C  CB   . ILE A 1 140 ? 33.066  -15.472 -45.017 1.00 41.92  ? 140 ILE L CB   1 
ATOM   1115 C  CG1  . ILE A 1 140 ? 31.713  -14.842 -44.699 1.00 41.29  ? 140 ILE L CG1  1 
ATOM   1116 C  CG2  . ILE A 1 140 ? 33.312  -15.624 -46.512 1.00 45.58  ? 140 ILE L CG2  1 
ATOM   1117 C  CD1  . ILE A 1 140 ? 31.597  -13.442 -45.188 1.00 45.05  ? 140 ILE L CD1  1 
ATOM   1118 N  N    . LEU A 1 141 ? 32.493  -17.265 -41.983 1.00 43.64  ? 141 LEU L N    1 
ATOM   1119 C  CA   . LEU A 1 141 ? 32.510  -17.071 -40.543 1.00 43.20  ? 141 LEU L CA   1 
ATOM   1120 C  C    . LEU A 1 141 ? 32.932  -18.350 -39.827 1.00 43.35  ? 141 LEU L C    1 
ATOM   1121 O  O    . LEU A 1 141 ? 33.223  -18.305 -38.649 1.00 43.77  ? 141 LEU L O    1 
ATOM   1122 C  CB   . LEU A 1 141 ? 31.113  -16.651 -40.082 1.00 46.21  ? 141 LEU L CB   1 
ATOM   1123 C  CG   . LEU A 1 141 ? 30.533  -15.374 -40.694 1.00 49.21  ? 141 LEU L CG   1 
ATOM   1124 C  CD1  . LEU A 1 141 ? 29.127  -15.141 -40.172 1.00 47.23  ? 141 LEU L CD1  1 
ATOM   1125 C  CD2  . LEU A 1 141 ? 31.388  -14.149 -40.406 1.00 52.75  ? 141 LEU L CD2  1 
ATOM   1126 N  N    . GLU A 1 142 ? 32.964  -19.495 -40.511 1.00 51.14  ? 142 GLU L N    1 
ATOM   1127 C  CA   . GLU A 1 142 ? 33.109  -20.778 -39.829 1.00 59.34  ? 142 GLU L CA   1 
ATOM   1128 C  C    . GLU A 1 142 ? 34.571  -20.954 -39.389 1.00 51.12  ? 142 GLU L C    1 
ATOM   1129 O  O    . GLU A 1 142 ? 35.392  -20.160 -39.893 1.00 52.16  ? 142 GLU L O    1 
ATOM   1130 C  CB   . GLU A 1 142 ? 32.636  -21.924 -40.734 1.00 62.12  ? 142 GLU L CB   1 
ATOM   1131 C  CG   . GLU A 1 142 ? 32.022  -23.106 -39.985 1.00 63.61  ? 142 GLU L CG   1 
ATOM   1132 C  CD   . GLU A 1 142 ? 30.599  -22.900 -39.486 1.00 61.01  ? 142 GLU L CD   1 
ATOM   1133 O  OE1  . GLU A 1 142 ? 29.789  -22.357 -40.249 1.00 72.46  ? 142 GLU L OE1  1 
ATOM   1134 O  OE2  . GLU A 1 142 ? 30.289  -23.307 -38.351 1.00 55.65  ? 142 GLU L OE2  1 
ATOM   1135 N  N    . ILE B 2 1   ? 13.653  -4.267  -48.686 1.00 22.27  ? 16  ILE H N    1 
ATOM   1136 C  CA   . ILE B 2 1   ? 13.675  -4.362  -47.202 1.00 20.55  ? 16  ILE H CA   1 
ATOM   1137 C  C    . ILE B 2 1   ? 13.649  -2.942  -46.678 1.00 20.60  ? 16  ILE H C    1 
ATOM   1138 O  O    . ILE B 2 1   ? 14.448  -2.131  -47.114 1.00 23.00  ? 16  ILE H O    1 
ATOM   1139 C  CB   . ILE B 2 1   ? 14.924  -5.115  -46.699 1.00 22.33  ? 16  ILE H CB   1 
ATOM   1140 C  CG1  . ILE B 2 1   ? 15.108  -6.482  -47.369 1.00 23.27  ? 16  ILE H CG1  1 
ATOM   1141 C  CG2  . ILE B 2 1   ? 14.907  -5.252  -45.192 1.00 23.34  ? 16  ILE H CG2  1 
ATOM   1142 C  CD1  . ILE B 2 1   ? 14.142  -7.527  -46.926 1.00 23.10  ? 16  ILE H CD1  1 
ATOM   1143 N  N    . VAL B 2 2   ? 12.741  -2.690  -45.731 1.00 21.05  ? 17  VAL H N    1 
ATOM   1144 C  CA   . VAL B 2 2   ? 12.635  -1.461  -44.970 1.00 19.31  ? 17  VAL H CA   1 
ATOM   1145 C  C    . VAL B 2 2   ? 13.194  -1.698  -43.562 1.00 19.83  ? 17  VAL H C    1 
ATOM   1146 O  O    . VAL B 2 2   ? 12.721  -2.581  -42.840 1.00 19.55  ? 17  VAL H O    1 
ATOM   1147 C  CB   . VAL B 2 2   ? 11.151  -1.044  -44.895 1.00 19.79  ? 17  VAL H CB   1 
ATOM   1148 C  CG1  . VAL B 2 2   ? 10.960  0.248   -44.111 1.00 21.11  ? 17  VAL H CG1  1 
ATOM   1149 C  CG2  . VAL B 2 2   ? 10.523  -0.903  -46.263 1.00 20.89  ? 17  VAL H CG2  1 
ATOM   1150 N  N    . GLY B 2 3   ? 14.140  -0.853  -43.137 1.00 19.95  ? 18  GLY H N    1 
ATOM   1151 C  CA   . GLY B 2 3   ? 14.624  -0.811  -41.762 1.00 19.08  ? 18  GLY H CA   1 
ATOM   1152 C  C    . GLY B 2 3   ? 15.588  -1.947  -41.431 1.00 19.63  ? 18  GLY H C    1 
ATOM   1153 O  O    . GLY B 2 3   ? 15.748  -2.336  -40.263 1.00 19.78  ? 18  GLY H O    1 
ATOM   1154 N  N    . GLY B 2 4   ? 16.205  -2.498  -42.470 1.00 19.10  ? 19  GLY H N    1 
ATOM   1155 C  CA   . GLY B 2 4   ? 17.125  -3.607  -42.315 1.00 21.06  ? 19  GLY H CA   1 
ATOM   1156 C  C    . GLY B 2 4   ? 18.546  -3.065  -42.315 1.00 23.99  ? 19  GLY H C    1 
ATOM   1157 O  O    . GLY B 2 4   ? 18.733  -1.865  -42.226 1.00 24.48  ? 19  GLY H O    1 
ATOM   1158 N  N    . LYS B 2 5   ? 19.531  -3.956  -42.433 1.00 28.36  ? 20  LYS H N    1 
ATOM   1159 C  CA   . LYS B 2 5   ? 20.932  -3.594  -42.527 1.00 26.06  ? 20  LYS H CA   1 
ATOM   1160 C  C    . LYS B 2 5   ? 21.492  -4.225  -43.797 1.00 21.55  ? 20  LYS H C    1 
ATOM   1161 O  O    . LYS B 2 5   ? 20.886  -5.131  -44.361 1.00 19.78  ? 20  LYS H O    1 
ATOM   1162 C  CB   . LYS B 2 5   ? 21.647  -4.084  -41.266 1.00 32.42  ? 20  LYS H CB   1 
ATOM   1163 C  CG   . LYS B 2 5   ? 21.557  -3.191  -40.034 1.00 42.39  ? 20  LYS H CG   1 
ATOM   1164 C  CD   . LYS B 2 5   ? 20.786  -3.748  -38.845 1.00 54.81  ? 20  LYS H CD   1 
ATOM   1165 C  CE   . LYS B 2 5   ? 19.282  -3.513  -38.890 1.00 74.77  ? 20  LYS H CE   1 
ATOM   1166 N  NZ   . LYS B 2 5   ? 18.893  -2.082  -38.758 1.00 76.66  ? 20  LYS H NZ   1 
ATOM   1167 N  N    . VAL B 2 6   ? 22.651  -3.742  -44.263 1.00 19.72  ? 21  VAL H N    1 
ATOM   1168 C  CA   . VAL B 2 6   ? 23.377  -4.420  -45.326 1.00 18.03  ? 21  VAL H CA   1 
ATOM   1169 C  C    . VAL B 2 6   ? 23.718  -5.822  -44.837 1.00 17.05  ? 21  VAL H C    1 
ATOM   1170 O  O    . VAL B 2 6   ? 23.989  -6.049  -43.669 1.00 16.31  ? 21  VAL H O    1 
ATOM   1171 C  CB   . VAL B 2 6   ? 24.615  -3.621  -45.795 1.00 18.68  ? 21  VAL H CB   1 
ATOM   1172 C  CG1  . VAL B 2 6   ? 25.434  -4.377  -46.834 1.00 17.44  ? 21  VAL H CG1  1 
ATOM   1173 C  CG2  . VAL B 2 6   ? 24.218  -2.253  -46.357 1.00 19.30  ? 21  VAL H CG2  1 
ATOM   1174 N  N    . CYS B 2 7   ? 23.579  -6.798  -45.722 1.00 17.76  ? 22  CYS H N    1 
ATOM   1175 C  CA   . CYS B 2 7   ? 24.130  -8.105  -45.452 1.00 17.71  ? 22  CYS H CA   1 
ATOM   1176 C  C    . CYS B 2 7   ? 25.583  -8.081  -45.910 1.00 18.91  ? 22  CYS H C    1 
ATOM   1177 O  O    . CYS B 2 7   ? 25.847  -7.918  -47.103 1.00 18.33  ? 22  CYS H O    1 
ATOM   1178 C  CB   . CYS B 2 7   ? 23.335  -9.207  -46.130 1.00 17.38  ? 22  CYS H CB   1 
ATOM   1179 S  SG   . CYS B 2 7   ? 23.895  -10.862 -45.654 1.00 16.91  ? 22  CYS H SG   1 
ATOM   1180 N  N    . PRO B 2 8   ? 26.553  -8.141  -44.968 1.00 19.79  ? 23  PRO H N    1 
ATOM   1181 C  CA   . PRO B 2 8   ? 27.975  -8.131  -45.322 1.00 20.83  ? 23  PRO H CA   1 
ATOM   1182 C  C    . PRO B 2 8   ? 28.260  -9.183  -46.377 1.00 21.16  ? 23  PRO H C    1 
ATOM   1183 O  O    . PRO B 2 8   ? 27.782  -10.313 -46.270 1.00 22.76  ? 23  PRO H O    1 
ATOM   1184 C  CB   . PRO B 2 8   ? 28.705  -8.477  -44.012 1.00 22.02  ? 23  PRO H CB   1 
ATOM   1185 C  CG   . PRO B 2 8   ? 27.722  -8.088  -42.905 1.00 21.10  ? 23  PRO H CG   1 
ATOM   1186 C  CD   . PRO B 2 8   ? 26.341  -8.234  -43.515 1.00 19.92  ? 23  PRO H CD   1 
ATOM   1187 N  N    . LYS B 2 9   ? 29.002  -8.784  -47.408 1.00 22.15  ? 24  LYS H N    1 
ATOM   1188 C  CA   . LYS B 2 9   ? 29.308  -9.638  -48.541 1.00 24.29  ? 24  LYS H CA   1 
ATOM   1189 C  C    . LYS B 2 9   ? 29.642  -11.028 -48.033 1.00 22.78  ? 24  LYS H C    1 
ATOM   1190 O  O    . LYS B 2 9   ? 30.439  -11.174 -47.119 1.00 21.99  ? 24  LYS H O    1 
ATOM   1191 C  CB   . LYS B 2 9   ? 30.496  -9.082  -49.324 1.00 29.57  ? 24  LYS H CB   1 
ATOM   1192 C  CG   . LYS B 2 9   ? 30.847  -9.827  -50.606 1.00 33.20  ? 24  LYS H CG   1 
ATOM   1193 C  CD   . LYS B 2 9   ? 31.762  -9.020  -51.520 1.00 37.14  ? 24  LYS H CD   1 
ATOM   1194 C  CE   . LYS B 2 9   ? 32.627  -9.870  -52.429 1.00 38.91  ? 24  LYS H CE   1 
ATOM   1195 N  NZ   . LYS B 2 9   ? 31.781  -10.677 -53.337 1.00 41.85  ? 24  LYS H NZ   1 
ATOM   1196 N  N    . GLY B 2 10  ? 28.994  -12.040 -48.596 1.00 20.24  ? 25  GLY H N    1 
ATOM   1197 C  CA   . GLY B 2 10  ? 29.296  -13.402 -48.203 1.00 20.16  ? 25  GLY H CA   1 
ATOM   1198 C  C    . GLY B 2 10  ? 28.381  -13.965 -47.121 1.00 19.40  ? 25  GLY H C    1 
ATOM   1199 O  O    . GLY B 2 10  ? 28.364  -15.179 -46.945 1.00 21.15  ? 25  GLY H O    1 
ATOM   1200 N  N    . GLU B 2 11  ? 27.668  -13.106 -46.370 1.00 18.93  ? 26  GLU H N    1 
ATOM   1201 C  CA   . GLU B 2 11  ? 26.946  -13.584 -45.194 1.00 18.38  ? 26  GLU H CA   1 
ATOM   1202 C  C    . GLU B 2 11  ? 25.472  -13.899 -45.481 1.00 15.82  ? 26  GLU H C    1 
ATOM   1203 O  O    . GLU B 2 11  ? 24.790  -14.298 -44.549 1.00 14.76  ? 26  GLU H O    1 
ATOM   1204 C  CB   . GLU B 2 11  ? 27.012  -12.584 -44.037 1.00 20.89  ? 26  GLU H CB   1 
ATOM   1205 C  CG   . GLU B 2 11  ? 28.409  -12.275 -43.545 1.00 22.64  ? 26  GLU H CG   1 
ATOM   1206 C  CD   . GLU B 2 11  ? 28.513  -11.594 -42.179 1.00 26.05  ? 26  GLU H CD   1 
ATOM   1207 O  OE1  . GLU B 2 11  ? 27.577  -11.686 -41.356 1.00 25.05  ? 26  GLU H OE1  1 
ATOM   1208 O  OE2  . GLU B 2 11  ? 29.548  -10.949 -41.936 1.00 33.29  ? 26  GLU H OE2  1 
ATOM   1209 N  N    . CYS B 2 12  ? 25.010  -13.757 -46.746 1.00 15.26  ? 27  CYS H N    1 
ATOM   1210 C  CA   . CYS B 2 12  ? 23.702  -14.184 -47.239 1.00 14.87  ? 27  CYS H CA   1 
ATOM   1211 C  C    . CYS B 2 12  ? 23.900  -15.007 -48.506 1.00 15.83  ? 27  CYS H C    1 
ATOM   1212 O  O    . CYS B 2 12  ? 23.293  -14.733 -49.546 1.00 16.62  ? 27  CYS H O    1 
ATOM   1213 C  CB   . CYS B 2 12  ? 22.776  -12.999 -47.528 1.00 15.03  ? 27  CYS H CB   1 
ATOM   1214 S  SG   . CYS B 2 12  ? 22.331  -12.034 -46.049 1.00 17.29  ? 27  CYS H SG   1 
ATOM   1215 N  N    . PRO B 2 13  ? 24.754  -16.054 -48.472 1.00 16.76  ? 28  PRO H N    1 
ATOM   1216 C  CA   . PRO B 2 13  ? 25.320  -16.633 -49.698 1.00 16.26  ? 28  PRO H CA   1 
ATOM   1217 C  C    . PRO B 2 13  ? 24.393  -17.465 -50.586 1.00 16.60  ? 28  PRO H C    1 
ATOM   1218 O  O    . PRO B 2 13  ? 24.775  -17.895 -51.671 1.00 16.63  ? 28  PRO H O    1 
ATOM   1219 C  CB   . PRO B 2 13  ? 26.446  -17.510 -49.119 1.00 16.19  ? 28  PRO H CB   1 
ATOM   1220 C  CG   . PRO B 2 13  ? 25.935  -17.959 -47.784 1.00 15.75  ? 28  PRO H CG   1 
ATOM   1221 C  CD   . PRO B 2 13  ? 25.191  -16.760 -47.259 1.00 16.18  ? 28  PRO H CD   1 
ATOM   1222 N  N    . TRP B 2 14  ? 23.179  -17.700 -50.089 1.00 17.33  ? 29  TRP H N    1 
ATOM   1223 C  CA   . TRP B 2 14  ? 22.142  -18.436 -50.786 1.00 16.45  ? 29  TRP H CA   1 
ATOM   1224 C  C    . TRP B 2 14  ? 21.109  -17.506 -51.412 1.00 16.52  ? 29  TRP H C    1 
ATOM   1225 O  O    . TRP B 2 14  ? 20.157  -17.998 -52.011 1.00 16.63  ? 29  TRP H O    1 
ATOM   1226 C  CB   . TRP B 2 14  ? 21.432  -19.401 -49.824 1.00 15.34  ? 29  TRP H CB   1 
ATOM   1227 C  CG   . TRP B 2 14  ? 21.245  -18.823 -48.462 1.00 14.63  ? 29  TRP H CG   1 
ATOM   1228 C  CD1  . TRP B 2 14  ? 20.436  -17.784 -48.123 1.00 15.41  ? 29  TRP H CD1  1 
ATOM   1229 C  CD2  . TRP B 2 14  ? 21.933  -19.205 -47.255 1.00 14.61  ? 29  TRP H CD2  1 
ATOM   1230 N  NE1  . TRP B 2 14  ? 20.527  -17.529 -46.782 1.00 14.84  ? 29  TRP H NE1  1 
ATOM   1231 C  CE2  . TRP B 2 14  ? 21.455  -18.360 -46.232 1.00 14.29  ? 29  TRP H CE2  1 
ATOM   1232 C  CE3  . TRP B 2 14  ? 22.912  -20.160 -46.954 1.00 14.99  ? 29  TRP H CE3  1 
ATOM   1233 C  CZ2  . TRP B 2 14  ? 21.896  -18.451 -44.923 1.00 15.25  ? 29  TRP H CZ2  1 
ATOM   1234 C  CZ3  . TRP B 2 14  ? 23.380  -20.232 -45.663 1.00 16.09  ? 29  TRP H CZ3  1 
ATOM   1235 C  CH2  . TRP B 2 14  ? 22.855  -19.406 -44.656 1.00 16.85  ? 29  TRP H CH2  1 
ATOM   1236 N  N    . GLN B 2 15  ? 21.281  -16.188 -51.261 1.00 16.30  ? 30  GLN H N    1 
ATOM   1237 C  CA   . GLN B 2 15  ? 20.444  -15.243 -51.969 1.00 15.78  ? 30  GLN H CA   1 
ATOM   1238 C  C    . GLN B 2 15  ? 20.696  -15.387 -53.461 1.00 17.26  ? 30  GLN H C    1 
ATOM   1239 O  O    . GLN B 2 15  ? 21.837  -15.492 -53.897 1.00 15.74  ? 30  GLN H O    1 
ATOM   1240 C  CB   . GLN B 2 15  ? 20.790  -13.812 -51.598 1.00 15.85  ? 30  GLN H CB   1 
ATOM   1241 C  CG   . GLN B 2 15  ? 19.971  -12.750 -52.313 1.00 15.30  ? 30  GLN H CG   1 
ATOM   1242 C  CD   . GLN B 2 15  ? 18.542  -12.753 -51.829 1.00 15.99  ? 30  GLN H CD   1 
ATOM   1243 O  OE1  . GLN B 2 15  ? 18.256  -12.903 -50.652 1.00 19.16  ? 30  GLN H OE1  1 
ATOM   1244 N  NE2  . GLN B 2 15  ? 17.601  -12.638 -52.737 1.00 15.98  ? 30  GLN H NE2  1 
ATOM   1245 N  N    . VAL B 2 16  ? 19.593  -15.402 -54.217 1.00 19.63  ? 31  VAL H N    1 
ATOM   1246 C  CA   . VAL B 2 16  ? 19.605  -15.415 -55.672 1.00 18.57  ? 31  VAL H CA   1 
ATOM   1247 C  C    . VAL B 2 16  ? 18.959  -14.117 -56.140 1.00 19.26  ? 31  VAL H C    1 
ATOM   1248 O  O    . VAL B 2 16  ? 18.029  -13.597 -55.516 1.00 20.79  ? 31  VAL H O    1 
ATOM   1249 C  CB   . VAL B 2 16  ? 18.823  -16.618 -56.227 1.00 18.15  ? 31  VAL H CB   1 
ATOM   1250 C  CG1  . VAL B 2 16  ? 18.791  -16.608 -57.746 1.00 17.87  ? 31  VAL H CG1  1 
ATOM   1251 C  CG2  . VAL B 2 16  ? 19.328  -17.945 -55.673 1.00 18.52  ? 31  VAL H CG2  1 
ATOM   1252 N  N    . LEU B 2 17  ? 19.478  -13.610 -57.248 1.00 20.41  ? 32  LEU H N    1 
ATOM   1253 C  CA   . LEU B 2 17  ? 18.862  -12.542 -57.998 1.00 21.89  ? 32  LEU H CA   1 
ATOM   1254 C  C    . LEU B 2 17  ? 18.388  -13.135 -59.317 1.00 21.60  ? 32  LEU H C    1 
ATOM   1255 O  O    . LEU B 2 17  ? 19.118  -13.907 -59.925 1.00 20.31  ? 32  LEU H O    1 
ATOM   1256 C  CB   . LEU B 2 17  ? 19.899  -11.452 -58.229 1.00 24.52  ? 32  LEU H CB   1 
ATOM   1257 C  CG   . LEU B 2 17  ? 19.453  -10.282 -59.098 1.00 26.65  ? 32  LEU H CG   1 
ATOM   1258 C  CD1  . LEU B 2 17  ? 18.308  -9.508  -58.444 1.00 26.56  ? 32  LEU H CD1  1 
ATOM   1259 C  CD2  . LEU B 2 17  ? 20.638  -9.369  -59.386 1.00 27.43  ? 32  LEU H CD2  1 
ATOM   1260 N  N    . LEU B 2 18  ? 17.125  -12.849 -59.654 1.00 21.18  ? 33  LEU H N    1 
ATOM   1261 C  CA   . LEU B 2 18  ? 16.562  -13.216 -60.926 1.00 21.21  ? 33  LEU H CA   1 
ATOM   1262 C  C    . LEU B 2 18  ? 16.433  -11.954 -61.770 1.00 23.75  ? 33  LEU H C    1 
ATOM   1263 O  O    . LEU B 2 18  ? 15.920  -10.957 -61.282 1.00 22.41  ? 33  LEU H O    1 
ATOM   1264 C  CB   . LEU B 2 18  ? 15.191  -13.845 -60.682 1.00 19.91  ? 33  LEU H CB   1 
ATOM   1265 C  CG   . LEU B 2 18  ? 15.150  -15.157 -59.900 1.00 20.23  ? 33  LEU H CG   1 
ATOM   1266 C  CD1  . LEU B 2 18  ? 13.693  -15.576 -59.685 1.00 20.88  ? 33  LEU H CD1  1 
ATOM   1267 C  CD2  . LEU B 2 18  ? 15.928  -16.276 -60.593 1.00 18.85  ? 33  LEU H CD2  1 
ATOM   1268 N  N    . LEU B 2 19  ? 16.878  -12.042 -63.036 1.00 26.60  ? 34  LEU H N    1 
ATOM   1269 C  CA   . LEU B 2 19  ? 16.762  -10.990 -64.036 1.00 27.36  ? 34  LEU H CA   1 
ATOM   1270 C  C    . LEU B 2 19  ? 15.986  -11.534 -65.232 1.00 29.00  ? 34  LEU H C    1 
ATOM   1271 O  O    . LEU B 2 19  ? 16.148  -12.712 -65.552 1.00 27.69  ? 34  LEU H O    1 
ATOM   1272 C  CB   . LEU B 2 19  ? 18.162  -10.583 -64.504 1.00 27.07  ? 34  LEU H CB   1 
ATOM   1273 C  CG   . LEU B 2 19  ? 19.150  -10.179 -63.419 1.00 25.12  ? 34  LEU H CG   1 
ATOM   1274 C  CD1  . LEU B 2 19  ? 20.545  -10.199 -63.980 1.00 25.50  ? 34  LEU H CD1  1 
ATOM   1275 C  CD2  . LEU B 2 19  ? 18.812  -8.819  -62.855 1.00 25.62  ? 34  LEU H CD2  1 
ATOM   1276 N  N    . VAL B 2 20  ? 15.175  -10.673 -65.873 1.00 31.14  ? 35  VAL H N    1 
ATOM   1277 C  CA   . VAL B 2 20  ? 14.537  -10.980 -67.151 1.00 35.39  ? 35  VAL H CA   1 
ATOM   1278 C  C    . VAL B 2 20  ? 14.841  -9.865  -68.156 1.00 33.36  ? 35  VAL H C    1 
ATOM   1279 O  O    . VAL B 2 20  ? 14.947  -8.695  -67.718 1.00 34.19  ? 35  VAL H O    1 
ATOM   1280 C  CB   . VAL B 2 20  ? 13.013  -11.156 -67.034 1.00 38.48  ? 35  VAL H CB   1 
ATOM   1281 C  CG1  . VAL B 2 20  ? 12.681  -12.413 -66.260 1.00 45.27  ? 35  VAL H CG1  1 
ATOM   1282 C  CG2  . VAL B 2 20  ? 12.324  -9.945  -66.418 1.00 37.88  ? 35  VAL H CG2  1 
ATOM   1283 N  N    . ASN B 2 21  ? 16.051  -10.344 -69.552 1.00 52.61  ? 36  ASN H N    1 
ATOM   1284 C  CA   . ASN B 2 21  ? 16.652  -9.228  -70.342 1.00 58.94  ? 36  ASN H CA   1 
ATOM   1285 C  C    . ASN B 2 21  ? 17.124  -8.113  -69.402 1.00 45.73  ? 36  ASN H C    1 
ATOM   1286 O  O    . ASN B 2 21  ? 16.696  -6.966  -69.529 1.00 45.48  ? 36  ASN H O    1 
ATOM   1287 C  CB   . ASN B 2 21  ? 15.733  -8.756  -71.484 1.00 67.31  ? 36  ASN H CB   1 
ATOM   1288 C  CG   . ASN B 2 21  ? 14.287  -8.542  -71.079 1.00 82.17  ? 36  ASN H CG   1 
ATOM   1289 O  OD1  . ASN B 2 21  ? 13.975  -7.621  -70.328 1.00 97.16  ? 36  ASN H OD1  1 
ATOM   1290 N  ND2  . ASN B 2 21  ? 13.394  -9.383  -71.578 1.00 83.85  ? 36  ASN H ND2  1 
ATOM   1291 N  N    . GLY B 2 22  ? 18.017  -8.476  -68.463 1.00 39.33  ? 37  GLY H N    1 
ATOM   1292 C  CA   . GLY B 2 22  ? 18.888  -7.531  -67.779 1.00 34.40  ? 37  GLY H CA   1 
ATOM   1293 C  C    . GLY B 2 22  ? 18.218  -6.758  -66.646 1.00 31.83  ? 37  GLY H C    1 
ATOM   1294 O  O    . GLY B 2 22  ? 18.916  -6.072  -65.911 1.00 33.60  ? 37  GLY H O    1 
ATOM   1295 N  N    . ALA B 2 23  ? 16.887  -6.872  -66.515 1.00 30.68  ? 38  ALA H N    1 
ATOM   1296 C  CA   . ALA B 2 23  ? 16.111  -6.153  -65.512 1.00 32.36  ? 38  ALA H CA   1 
ATOM   1297 C  C    . ALA B 2 23  ? 15.866  -7.037  -64.286 1.00 29.86  ? 38  ALA H C    1 
ATOM   1298 O  O    . ALA B 2 23  ? 15.576  -8.230  -64.402 1.00 28.59  ? 38  ALA H O    1 
ATOM   1299 C  CB   . ALA B 2 23  ? 14.789  -5.709  -66.097 1.00 32.86  ? 38  ALA H CB   1 
ATOM   1300 N  N    . GLN B 2 24  ? 15.962  -6.407  -63.117 1.00 27.34  ? 39  GLN H N    1 
ATOM   1301 C  CA   . GLN B 2 24  ? 15.724  -7.043  -61.834 1.00 27.68  ? 39  GLN H CA   1 
ATOM   1302 C  C    . GLN B 2 24  ? 14.268  -7.488  -61.738 1.00 23.99  ? 39  GLN H C    1 
ATOM   1303 O  O    . GLN B 2 24  ? 13.352  -6.684  -61.903 1.00 22.84  ? 39  GLN H O    1 
ATOM   1304 C  CB   . GLN B 2 24  ? 16.092  -6.022  -60.757 1.00 31.67  ? 39  GLN H CB   1 
ATOM   1305 C  CG   . GLN B 2 24  ? 15.952  -6.498  -59.322 1.00 32.84  ? 39  GLN H CG   1 
ATOM   1306 C  CD   . GLN B 2 24  ? 16.195  -5.331  -58.398 1.00 35.32  ? 39  GLN H CD   1 
ATOM   1307 O  OE1  . GLN B 2 24  ? 16.937  -4.411  -58.735 1.00 31.12  ? 39  GLN H OE1  1 
ATOM   1308 N  NE2  . GLN B 2 24  ? 15.562  -5.354  -57.229 1.00 38.26  ? 39  GLN H NE2  1 
ATOM   1309 N  N    . LEU B 2 25  ? 14.061  -8.766  -61.430 1.00 21.88  ? 40  LEU H N    1 
ATOM   1310 C  CA   . LEU B 2 25  ? 12.722  -9.314  -61.393 1.00 22.59  ? 40  LEU H CA   1 
ATOM   1311 C  C    . LEU B 2 25  ? 12.316  -9.649  -59.953 1.00 21.81  ? 40  LEU H C    1 
ATOM   1312 O  O    . LEU B 2 25  ? 11.335  -9.122  -59.431 1.00 20.65  ? 40  LEU H O    1 
ATOM   1313 C  CB   . LEU B 2 25  ? 12.679  -10.532 -62.324 1.00 23.86  ? 40  LEU H CB   1 
ATOM   1314 C  CG   . LEU B 2 25  ? 11.392  -11.360 -62.274 1.00 25.81  ? 40  LEU H CG   1 
ATOM   1315 C  CD1  . LEU B 2 25  ? 10.317  -10.735 -63.130 1.00 24.16  ? 40  LEU H CD1  1 
ATOM   1316 C  CD2  . LEU B 2 25  ? 11.650  -12.796 -62.701 1.00 29.33  ? 40  LEU H CD2  1 
ATOM   1317 N  N    . CYS B 2 26  ? 13.043  -10.572 -59.325 1.00 22.44  ? 41  CYS H N    1 
ATOM   1318 C  CA   . CYS B 2 26  ? 12.680  -11.099 -58.012 1.00 19.78  ? 41  CYS H CA   1 
ATOM   1319 C  C    . CYS B 2 26  ? 13.932  -11.679 -57.349 1.00 16.55  ? 41  CYS H C    1 
ATOM   1320 O  O    . CYS B 2 26  ? 14.972  -11.818 -57.981 1.00 14.88  ? 41  CYS H O    1 
ATOM   1321 C  CB   . CYS B 2 26  ? 11.634  -12.215 -58.122 1.00 19.40  ? 41  CYS H CB   1 
ATOM   1322 S  SG   . CYS B 2 26  ? 9.903   -11.684 -58.282 1.00 19.26  ? 41  CYS H SG   1 
ATOM   1323 N  N    . GLY B 2 27  ? 13.796  -12.030 -56.070 1.00 15.43  ? 42  GLY H N    1 
ATOM   1324 C  CA   . GLY B 2 27  ? 14.751  -12.860 -55.371 1.00 14.68  ? 42  GLY H CA   1 
ATOM   1325 C  C    . GLY B 2 27  ? 14.460  -14.344 -55.525 1.00 15.22  ? 42  GLY H C    1 
ATOM   1326 O  O    . GLY B 2 27  ? 13.441  -14.761 -56.040 1.00 15.35  ? 42  GLY H O    1 
ATOM   1327 N  N    . GLY B 2 28  ? 15.414  -15.152 -55.073 1.00 17.68  ? 43  GLY H N    1 
ATOM   1328 C  CA   . GLY B 2 28  ? 15.281  -16.598 -55.019 1.00 15.79  ? 43  GLY H CA   1 
ATOM   1329 C  C    . GLY B 2 28  ? 16.178  -17.128 -53.906 1.00 15.14  ? 43  GLY H C    1 
ATOM   1330 O  O    . GLY B 2 28  ? 16.841  -16.342 -53.249 1.00 12.84  ? 43  GLY H O    1 
ATOM   1331 N  N    . THR B 2 29  ? 16.177  -18.452 -53.725 1.00 14.99  ? 44  THR H N    1 
ATOM   1332 C  CA   . THR B 2 29  ? 16.953  -19.102 -52.690 1.00 16.15  ? 44  THR H CA   1 
ATOM   1333 C  C    . THR B 2 29  ? 17.549  -20.374 -53.293 1.00 17.12  ? 44  THR H C    1 
ATOM   1334 O  O    . THR B 2 29  ? 16.799  -21.235 -53.749 1.00 17.74  ? 44  THR H O    1 
ATOM   1335 C  CB   . THR B 2 29  ? 16.105  -19.479 -51.458 1.00 16.79  ? 44  THR H CB   1 
ATOM   1336 O  OG1  . THR B 2 29  ? 15.391  -18.365 -50.926 1.00 17.40  ? 44  THR H OG1  1 
ATOM   1337 C  CG2  . THR B 2 29  ? 16.947  -20.042 -50.340 1.00 17.26  ? 44  THR H CG2  1 
ATOM   1338 N  N    . LEU B 2 30  ? 18.879  -20.495 -53.271 1.00 17.47  ? 45  LEU H N    1 
ATOM   1339 C  CA   . LEU B 2 30  ? 19.558  -21.710 -53.717 1.00 18.29  ? 45  LEU H CA   1 
ATOM   1340 C  C    . LEU B 2 30  ? 19.449  -22.798 -52.648 1.00 17.31  ? 45  LEU H C    1 
ATOM   1341 O  O    . LEU B 2 30  ? 19.838  -22.570 -51.515 1.00 15.48  ? 45  LEU H O    1 
ATOM   1342 C  CB   . LEU B 2 30  ? 21.030  -21.363 -53.970 1.00 17.89  ? 45  LEU H CB   1 
ATOM   1343 C  CG   . LEU B 2 30  ? 21.875  -22.460 -54.595 1.00 17.49  ? 45  LEU H CG   1 
ATOM   1344 C  CD1  . LEU B 2 30  ? 21.632  -22.519 -56.086 1.00 17.49  ? 45  LEU H CD1  1 
ATOM   1345 C  CD2  . LEU B 2 30  ? 23.347  -22.237 -54.300 1.00 18.20  ? 45  LEU H CD2  1 
ATOM   1346 N  N    . ILE B 2 31  ? 18.981  -23.989 -53.044 1.00 18.65  ? 46  ILE H N    1 
ATOM   1347 C  CA   . ILE B 2 31  ? 18.801  -25.125 -52.139 1.00 19.41  ? 46  ILE H CA   1 
ATOM   1348 C  C    . ILE B 2 31  ? 19.728  -26.269 -52.527 1.00 19.79  ? 46  ILE H C    1 
ATOM   1349 O  O    . ILE B 2 31  ? 19.888  -27.212 -51.768 1.00 22.00  ? 46  ILE H O    1 
ATOM   1350 C  CB   . ILE B 2 31  ? 17.317  -25.571 -52.080 1.00 20.07  ? 46  ILE H CB   1 
ATOM   1351 C  CG1  . ILE B 2 31  ? 16.783  -25.918 -53.473 1.00 21.63  ? 46  ILE H CG1  1 
ATOM   1352 C  CG2  . ILE B 2 31  ? 16.466  -24.491 -51.383 1.00 18.65  ? 46  ILE H CG2  1 
ATOM   1353 C  CD1  . ILE B 2 31  ? 15.463  -26.646 -53.495 1.00 22.41  ? 46  ILE H CD1  1 
ATOM   1354 N  N    . ASN B 2 32  ? 20.337  -26.193 -53.708 1.00 21.95  ? 47  ASN H N    1 
ATOM   1355 C  CA   . ASN B 2 32  ? 21.456  -27.049 -54.070 1.00 24.57  ? 47  ASN H CA   1 
ATOM   1356 C  C    . ASN B 2 32  ? 22.055  -26.483 -55.354 1.00 25.86  ? 47  ASN H C    1 
ATOM   1357 O  O    . ASN B 2 32  ? 21.761  -25.350 -55.710 1.00 29.20  ? 47  ASN H O    1 
ATOM   1358 C  CB   . ASN B 2 32  ? 21.044  -28.512 -54.225 1.00 25.87  ? 47  ASN H CB   1 
ATOM   1359 C  CG   . ASN B 2 32  ? 19.884  -28.659 -55.181 1.00 28.73  ? 47  ASN H CG   1 
ATOM   1360 O  OD1  . ASN B 2 32  ? 19.902  -28.162 -56.316 1.00 29.25  ? 47  ASN H OD1  1 
ATOM   1361 N  ND2  . ASN B 2 32  ? 18.850  -29.315 -54.693 1.00 30.08  ? 47  ASN H ND2  1 
ATOM   1362 N  N    . THR B 2 33  ? 22.853  -27.268 -56.074 1.00 25.40  ? 48  THR H N    1 
ATOM   1363 C  CA   . THR B 2 33  ? 23.679  -26.704 -57.132 1.00 25.25  ? 48  THR H CA   1 
ATOM   1364 C  C    . THR B 2 33  ? 22.852  -26.371 -58.368 1.00 26.26  ? 48  THR H C    1 
ATOM   1365 O  O    . THR B 2 33  ? 23.295  -25.537 -59.163 1.00 27.49  ? 48  THR H O    1 
ATOM   1366 C  CB   . THR B 2 33  ? 24.883  -27.601 -57.450 1.00 25.20  ? 48  THR H CB   1 
ATOM   1367 O  OG1  . THR B 2 33  ? 24.499  -28.931 -57.793 1.00 23.94  ? 48  THR H OG1  1 
ATOM   1368 C  CG2  . THR B 2 33  ? 25.838  -27.694 -56.279 1.00 26.60  ? 48  THR H CG2  1 
ATOM   1369 N  N    . ILE B 2 34  ? 21.664  -26.977 -58.524 1.00 25.83  ? 49  ILE H N    1 
ATOM   1370 C  CA   . ILE B 2 34  ? 20.911  -26.764 -59.755 1.00 30.15  ? 49  ILE H CA   1 
ATOM   1371 C  C    . ILE B 2 34  ? 19.495  -26.264 -59.494 1.00 25.77  ? 49  ILE H C    1 
ATOM   1372 O  O    . ILE B 2 34  ? 18.814  -25.944 -60.451 1.00 26.89  ? 49  ILE H O    1 
ATOM   1373 C  CB   . ILE B 2 34  ? 20.873  -28.023 -60.643 1.00 35.60  ? 49  ILE H CB   1 
ATOM   1374 C  CG1  . ILE B 2 34  ? 20.414  -29.249 -59.855 1.00 43.96  ? 49  ILE H CG1  1 
ATOM   1375 C  CG2  . ILE B 2 34  ? 22.220  -28.273 -61.291 1.00 38.43  ? 49  ILE H CG2  1 
ATOM   1376 C  CD1  . ILE B 2 34  ? 19.864  -30.350 -60.717 1.00 49.01  ? 49  ILE H CD1  1 
ATOM   1377 N  N    . TRP B 2 35  ? 19.058  -26.205 -58.234 1.00 24.72  ? 50  TRP H N    1 
ATOM   1378 C  CA   . TRP B 2 35  ? 17.674  -25.878 -57.898 1.00 22.65  ? 50  TRP H CA   1 
ATOM   1379 C  C    . TRP B 2 35  ? 17.571  -24.617 -57.039 1.00 20.71  ? 50  TRP H C    1 
ATOM   1380 O  O    . TRP B 2 35  ? 18.239  -24.461 -56.011 1.00 19.67  ? 50  TRP H O    1 
ATOM   1381 C  CB   . TRP B 2 35  ? 16.998  -27.045 -57.171 1.00 23.54  ? 50  TRP H CB   1 
ATOM   1382 C  CG   . TRP B 2 35  ? 16.758  -28.268 -58.015 1.00 24.39  ? 50  TRP H CG   1 
ATOM   1383 C  CD1  . TRP B 2 35  ? 17.418  -29.462 -57.945 1.00 22.46  ? 50  TRP H CD1  1 
ATOM   1384 C  CD2  . TRP B 2 35  ? 15.739  -28.421 -59.028 1.00 23.88  ? 50  TRP H CD2  1 
ATOM   1385 N  NE1  . TRP B 2 35  ? 16.905  -30.317 -58.886 1.00 24.88  ? 50  TRP H NE1  1 
ATOM   1386 C  CE2  . TRP B 2 35  ? 15.869  -29.721 -59.548 1.00 24.00  ? 50  TRP H CE2  1 
ATOM   1387 C  CE3  . TRP B 2 35  ? 14.732  -27.598 -59.539 1.00 24.44  ? 50  TRP H CE3  1 
ATOM   1388 C  CZ2  . TRP B 2 35  ? 15.027  -30.210 -60.541 1.00 25.56  ? 50  TRP H CZ2  1 
ATOM   1389 C  CZ3  . TRP B 2 35  ? 13.891  -28.090 -60.506 1.00 22.80  ? 50  TRP H CZ3  1 
ATOM   1390 C  CH2  . TRP B 2 35  ? 14.033  -29.378 -60.999 1.00 23.79  ? 50  TRP H CH2  1 
ATOM   1391 N  N    . VAL B 2 36  ? 16.638  -23.754 -57.448 1.00 20.25  ? 51  VAL H N    1 
ATOM   1392 C  CA   . VAL B 2 36  ? 16.360  -22.488 -56.782 1.00 18.95  ? 51  VAL H CA   1 
ATOM   1393 C  C    . VAL B 2 36  ? 14.867  -22.397 -56.447 1.00 17.64  ? 51  VAL H C    1 
ATOM   1394 O  O    . VAL B 2 36  ? 14.025  -22.810 -57.233 1.00 16.28  ? 51  VAL H O    1 
ATOM   1395 C  CB   . VAL B 2 36  ? 16.823  -21.322 -57.667 1.00 17.41  ? 51  VAL H CB   1 
ATOM   1396 C  CG1  . VAL B 2 36  ? 16.285  -20.001 -57.184 1.00 17.40  ? 51  VAL H CG1  1 
ATOM   1397 C  CG2  . VAL B 2 36  ? 18.341  -21.267 -57.770 1.00 18.47  ? 51  VAL H CG2  1 
ATOM   1398 N  N    . VAL B 2 37  ? 14.539  -21.890 -55.253 1.00 17.20  ? 52  VAL H N    1 
ATOM   1399 C  CA   . VAL B 2 37  ? 13.146  -21.713 -54.889 1.00 17.28  ? 52  VAL H CA   1 
ATOM   1400 C  C    . VAL B 2 37  ? 12.819  -20.233 -54.976 1.00 16.58  ? 52  VAL H C    1 
ATOM   1401 O  O    . VAL B 2 37  ? 13.596  -19.406 -54.501 1.00 18.65  ? 52  VAL H O    1 
ATOM   1402 C  CB   . VAL B 2 37  ? 12.824  -22.293 -53.500 1.00 17.51  ? 52  VAL H CB   1 
ATOM   1403 C  CG1  . VAL B 2 37  ? 11.406  -21.947 -53.028 1.00 17.01  ? 52  VAL H CG1  1 
ATOM   1404 C  CG2  . VAL B 2 37  ? 13.025  -23.795 -53.503 1.00 17.37  ? 52  VAL H CG2  1 
ATOM   1405 N  N    . SER B 2 38  ? 11.656  -19.926 -55.548 1.00 15.32  ? 53  SER H N    1 
ATOM   1406 C  CA   . SER B 2 38  ? 11.204  -18.538 -55.621 1.00 16.45  ? 53  SER H CA   1 
ATOM   1407 C  C    . SER B 2 38  ? 9.679   -18.432 -55.457 1.00 15.47  ? 53  SER H C    1 
ATOM   1408 O  O    . SER B 2 38  ? 9.026   -19.309 -54.910 1.00 14.93  ? 53  SER H O    1 
ATOM   1409 C  CB   . SER B 2 38  ? 11.749  -17.876 -56.896 1.00 15.60  ? 53  SER H CB   1 
ATOM   1410 O  OG   . SER B 2 38  ? 11.465  -16.487 -56.947 1.00 13.96  ? 53  SER H OG   1 
ATOM   1411 N  N    . ALA B 2 39  ? 9.106   -17.305 -55.860 1.00 17.54  ? 54  ALA H N    1 
ATOM   1412 C  CA   . ALA B 2 39  ? 7.667   -17.099 -55.740 1.00 20.31  ? 54  ALA H CA   1 
ATOM   1413 C  C    . ALA B 2 39  ? 6.981   -17.246 -57.101 1.00 19.06  ? 54  ALA H C    1 
ATOM   1414 O  O    . ALA B 2 39  ? 7.515   -16.864 -58.136 1.00 19.56  ? 54  ALA H O    1 
ATOM   1415 C  CB   . ALA B 2 39  ? 7.406   -15.747 -55.124 1.00 23.08  ? 54  ALA H CB   1 
ATOM   1416 N  N    . ALA B 2 40  ? 5.814   -17.877 -57.105 1.00 20.28  ? 55  ALA H N    1 
ATOM   1417 C  CA   . ALA B 2 40  ? 5.098   -18.131 -58.345 1.00 20.88  ? 55  ALA H CA   1 
ATOM   1418 C  C    . ALA B 2 40  ? 4.732   -16.816 -59.032 1.00 20.63  ? 55  ALA H C    1 
ATOM   1419 O  O    . ALA B 2 40  ? 4.757   -16.743 -60.261 1.00 19.57  ? 55  ALA H O    1 
ATOM   1420 C  CB   . ALA B 2 40  ? 3.868   -18.955 -58.073 1.00 22.02  ? 55  ALA H CB   1 
ATOM   1421 N  N    . HIS B 2 41  ? 4.405   -15.788 -58.232 1.00 20.39  ? 56  HIS H N    1 
ATOM   1422 C  CA   . HIS B 2 41  ? 3.794   -14.575 -58.762 1.00 21.40  ? 56  HIS H CA   1 
ATOM   1423 C  C    . HIS B 2 41  ? 4.807   -13.747 -59.560 1.00 21.60  ? 56  HIS H C    1 
ATOM   1424 O  O    . HIS B 2 41  ? 4.427   -12.810 -60.255 1.00 20.29  ? 56  HIS H O    1 
ATOM   1425 C  CB   . HIS B 2 41  ? 3.146   -13.762 -57.631 1.00 19.93  ? 56  HIS H CB   1 
ATOM   1426 C  CG   . HIS B 2 41  ? 4.094   -12.992 -56.758 1.00 20.76  ? 56  HIS H CG   1 
ATOM   1427 N  ND1  . HIS B 2 41  ? 4.773   -11.870 -57.195 1.00 21.43  ? 56  HIS H ND1  1 
ATOM   1428 C  CD2  . HIS B 2 41  ? 4.447   -13.140 -55.471 1.00 18.98  ? 56  HIS H CD2  1 
ATOM   1429 C  CE1  . HIS B 2 41  ? 5.510   -11.374 -56.212 1.00 18.93  ? 56  HIS H CE1  1 
ATOM   1430 N  NE2  . HIS B 2 41  ? 5.307   -12.123 -55.156 1.00 20.00  ? 56  HIS H NE2  1 
ATOM   1431 N  N    . CYS B 2 42  ? 6.096   -14.055 -59.367 1.00 21.62  ? 57  CYS H N    1 
ATOM   1432 C  CA   . CYS B 2 42  ? 7.213   -13.413 -60.039 1.00 20.72  ? 57  CYS H CA   1 
ATOM   1433 C  C    . CYS B 2 42  ? 7.178   -13.642 -61.543 1.00 21.05  ? 57  CYS H C    1 
ATOM   1434 O  O    . CYS B 2 42  ? 7.719   -12.824 -62.254 1.00 19.00  ? 57  CYS H O    1 
ATOM   1435 C  CB   . CYS B 2 42  ? 8.531   -13.960 -59.502 1.00 20.72  ? 57  CYS H CB   1 
ATOM   1436 S  SG   . CYS B 2 42  ? 8.921   -13.393 -57.827 1.00 20.35  ? 57  CYS H SG   1 
ATOM   1437 N  N    . PHE B 2 43  ? 6.495   -14.710 -62.004 1.00 25.15  ? 58  PHE H N    1 
ATOM   1438 C  CA   . PHE B 2 43  ? 6.504   -15.149 -63.395 1.00 24.91  ? 58  PHE H CA   1 
ATOM   1439 C  C    . PHE B 2 43  ? 5.184   -14.927 -64.120 1.00 27.25  ? 58  PHE H C    1 
ATOM   1440 O  O    . PHE B 2 43  ? 4.973   -15.471 -65.205 1.00 29.79  ? 58  PHE H O    1 
ATOM   1441 C  CB   . PHE B 2 43  ? 6.820   -16.639 -63.424 1.00 24.50  ? 58  PHE H CB   1 
ATOM   1442 C  CG   . PHE B 2 43  ? 8.123   -16.926 -62.735 1.00 28.29  ? 58  PHE H CG   1 
ATOM   1443 C  CD1  . PHE B 2 43  ? 9.320   -16.544 -63.319 1.00 27.15  ? 58  PHE H CD1  1 
ATOM   1444 C  CD2  . PHE B 2 43  ? 8.143   -17.467 -61.457 1.00 30.40  ? 58  PHE H CD2  1 
ATOM   1445 C  CE1  . PHE B 2 43  ? 10.521  -16.769 -62.670 1.00 30.67  ? 58  PHE H CE1  1 
ATOM   1446 C  CE2  . PHE B 2 43  ? 9.348   -17.695 -60.812 1.00 30.38  ? 58  PHE H CE2  1 
ATOM   1447 C  CZ   . PHE B 2 43  ? 10.531  -17.342 -61.417 1.00 32.43  ? 58  PHE H CZ   1 
ATOM   1448 N  N    . ASP B 2 44  ? 4.289   -14.138 -63.535 1.00 29.60  ? 59  ASP H N    1 
ATOM   1449 C  CA   . ASP B 2 44  ? 2.933   -14.053 -64.061 1.00 33.22  ? 59  ASP H CA   1 
ATOM   1450 C  C    . ASP B 2 44  ? 2.903   -13.369 -65.423 1.00 35.42  ? 59  ASP H C    1 
ATOM   1451 O  O    . ASP B 2 44  ? 1.998   -13.665 -66.200 1.00 33.28  ? 59  ASP H O    1 
ATOM   1452 C  CB   . ASP B 2 44  ? 1.977   -13.332 -63.101 1.00 30.90  ? 59  ASP H CB   1 
ATOM   1453 C  CG   . ASP B 2 44  ? 1.518   -14.226 -61.962 1.00 29.26  ? 59  ASP H CG   1 
ATOM   1454 O  OD1  . ASP B 2 44  ? 1.945   -15.410 -61.912 1.00 31.12  ? 59  ASP H OD1  1 
ATOM   1455 O  OD2  . ASP B 2 44  ? 0.743   -13.742 -61.157 1.00 29.28  ? 59  ASP H OD2  1 
ATOM   1456 N  N    . LYS B 2 45  ? 3.856   -12.449 -65.670 1.00 36.40  ? 60  LYS H N    1 
ATOM   1457 C  CA   . LYS B 2 45  ? 3.812   -11.571 -66.830 1.00 41.00  ? 60  LYS H CA   1 
ATOM   1458 C  C    . LYS B 2 45  ? 5.031   -11.771 -67.715 1.00 41.32  ? 60  LYS H C    1 
ATOM   1459 O  O    . LYS B 2 45  ? 5.257   -10.974 -68.611 1.00 40.49  ? 60  LYS H O    1 
ATOM   1460 C  CB   . LYS B 2 45  ? 3.820   -10.091 -66.437 1.00 48.77  ? 60  LYS H CB   1 
ATOM   1461 C  CG   . LYS B 2 45  ? 2.642   -9.604  -65.602 1.00 58.95  ? 60  LYS H CG   1 
ATOM   1462 C  CD   . LYS B 2 45  ? 2.863   -8.175  -65.106 1.00 68.55  ? 60  LYS H CD   1 
ATOM   1463 C  CE   . LYS B 2 45  ? 1.772   -7.645  -64.196 1.00 73.32  ? 60  LYS H CE   1 
ATOM   1464 N  NZ   . LYS B 2 45  ? 0.501   -7.428  -64.928 1.00 80.03  ? 60  LYS H NZ   1 
ATOM   1465 N  N    . ILE B 2 46  ? 5.829   -12.807 -67.460 1.00 45.31  ? 61  ILE H N    1 
ATOM   1466 C  CA   . ILE B 2 46  ? 6.977   -13.065 -68.309 1.00 50.81  ? 61  ILE H CA   1 
ATOM   1467 C  C    . ILE B 2 46  ? 6.389   -13.400 -69.665 1.00 56.49  ? 61  ILE H C    1 
ATOM   1468 O  O    . ILE B 2 46  ? 5.266   -13.881 -69.689 1.00 65.14  ? 61  ILE H O    1 
ATOM   1469 C  CB   . ILE B 2 46  ? 7.847   -14.225 -67.777 1.00 51.44  ? 61  ILE H CB   1 
ATOM   1470 C  CG1  . ILE B 2 46  ? 8.298   -13.987 -66.337 1.00 53.45  ? 61  ILE H CG1  1 
ATOM   1471 C  CG2  . ILE B 2 46  ? 9.046   -14.472 -68.681 1.00 51.23  ? 61  ILE H CG2  1 
ATOM   1472 C  CD1  . ILE B 2 46  ? 9.054   -12.698 -66.155 1.00 54.14  ? 61  ILE H CD1  1 
ATOM   1473 N  N    . LYS B 2 47  ? 7.117   -13.143 -70.759 1.00 65.87  ? 62  LYS H N    1 
ATOM   1474 C  CA   . LYS B 2 47  ? 6.889   -13.936 -71.959 1.00 79.34  ? 62  LYS H CA   1 
ATOM   1475 C  C    . LYS B 2 47  ? 8.172   -14.179 -72.752 1.00 70.03  ? 62  LYS H C    1 
ATOM   1476 O  O    . LYS B 2 47  ? 8.082   -14.551 -73.909 1.00 75.41  ? 62  LYS H O    1 
ATOM   1477 C  CB   . LYS B 2 47  ? 5.755   -13.323 -72.789 1.00 97.28  ? 62  LYS H CB   1 
ATOM   1478 C  CG   . LYS B 2 47  ? 4.368   -13.605 -72.215 1.00 116.73 ? 62  LYS H CG   1 
ATOM   1479 C  CD   . LYS B 2 47  ? 3.219   -13.372 -73.146 1.00 125.77 ? 62  LYS H CD   1 
ATOM   1480 C  CE   . LYS B 2 47  ? 3.350   -14.163 -74.427 1.00 133.07 ? 62  LYS H CE   1 
ATOM   1481 N  NZ   . LYS B 2 47  ? 2.105   -14.074 -75.209 1.00 135.41 ? 62  LYS H NZ   1 
ATOM   1482 N  N    . ASN B 2 48  ? 9.344   -14.078 -72.103 1.00 75.85  ? 63  ASN H N    1 
ATOM   1483 C  CA   . ASN B 2 48  ? 10.625  -14.405 -72.715 1.00 75.17  ? 63  ASN H CA   1 
ATOM   1484 C  C    . ASN B 2 48  ? 11.360  -15.449 -71.874 1.00 62.44  ? 63  ASN H C    1 
ATOM   1485 O  O    . ASN B 2 48  ? 12.426  -15.195 -71.318 1.00 55.20  ? 63  ASN H O    1 
ATOM   1486 C  CB   . ASN B 2 48  ? 11.488  -13.159 -72.896 1.00 83.42  ? 63  ASN H CB   1 
ATOM   1487 C  CG   . ASN B 2 48  ? 10.788  -12.108 -73.726 1.00 92.90  ? 63  ASN H CG   1 
ATOM   1488 O  OD1  . ASN B 2 48  ? 10.496  -11.016 -73.240 1.00 89.79  ? 63  ASN H OD1  1 
ATOM   1489 N  ND2  . ASN B 2 48  ? 10.492  -12.447 -74.970 1.00 98.05  ? 63  ASN H ND2  1 
ATOM   1490 N  N    . TRP B 2 49  ? 10.809  -16.660 -71.861 1.00 55.03  ? 64  TRP H N    1 
ATOM   1491 C  CA   . TRP B 2 49  ? 11.289  -17.735 -71.015 1.00 54.49  ? 64  TRP H CA   1 
ATOM   1492 C  C    . TRP B 2 49  ? 12.718  -18.156 -71.357 1.00 58.62  ? 64  TRP H C    1 
ATOM   1493 O  O    . TRP B 2 49  ? 13.149  -19.241 -70.964 1.00 58.40  ? 64  TRP H O    1 
ATOM   1494 C  CB   . TRP B 2 49  ? 10.300  -18.896 -71.146 1.00 55.51  ? 64  TRP H CB   1 
ATOM   1495 C  CG   . TRP B 2 49  ? 8.935   -18.499 -70.669 1.00 54.65  ? 64  TRP H CG   1 
ATOM   1496 C  CD1  . TRP B 2 49  ? 7.868   -18.102 -71.417 1.00 53.49  ? 64  TRP H CD1  1 
ATOM   1497 C  CD2  . TRP B 2 49  ? 8.511   -18.457 -69.293 1.00 57.18  ? 64  TRP H CD2  1 
ATOM   1498 N  NE1  . TRP B 2 49  ? 6.807   -17.809 -70.605 1.00 53.02  ? 64  TRP H NE1  1 
ATOM   1499 C  CE2  . TRP B 2 49  ? 7.168   -18.026 -69.301 1.00 55.14  ? 64  TRP H CE2  1 
ATOM   1500 C  CE3  . TRP B 2 49  ? 9.136   -18.741 -68.072 1.00 56.10  ? 64  TRP H CE3  1 
ATOM   1501 C  CZ2  . TRP B 2 49  ? 6.440   -17.883 -68.127 1.00 54.75  ? 64  TRP H CZ2  1 
ATOM   1502 C  CZ3  . TRP B 2 49  ? 8.408   -18.607 -66.912 1.00 56.27  ? 64  TRP H CZ3  1 
ATOM   1503 C  CH2  . TRP B 2 49  ? 7.078   -18.188 -66.946 1.00 57.00  ? 64  TRP H CH2  1 
ATOM   1504 N  N    . ARG B 2 50  ? 13.446  -17.281 -72.065 1.00 63.11  ? 65  ARG H N    1 
ATOM   1505 C  CA   . ARG B 2 50  ? 14.854  -17.482 -72.376 1.00 70.04  ? 65  ARG H CA   1 
ATOM   1506 C  C    . ARG B 2 50  ? 15.642  -16.186 -72.149 1.00 60.28  ? 65  ARG H C    1 
ATOM   1507 O  O    . ARG B 2 50  ? 16.817  -16.098 -72.474 1.00 56.61  ? 65  ARG H O    1 
ATOM   1508 C  CB   . ARG B 2 50  ? 15.004  -18.046 -73.800 1.00 86.43  ? 65  ARG H CB   1 
ATOM   1509 C  CG   . ARG B 2 50  ? 13.834  -17.807 -74.754 1.00 103.04 ? 65  ARG H CG   1 
ATOM   1510 C  CD   . ARG B 2 50  ? 13.511  -16.362 -75.119 1.00 113.58 ? 65  ARG H CD   1 
ATOM   1511 N  NE   . ARG B 2 50  ? 14.687  -15.521 -75.340 1.00 127.42 ? 65  ARG H NE   1 
ATOM   1512 C  CZ   . ARG B 2 50  ? 15.458  -15.514 -76.430 1.00 120.63 ? 65  ARG H CZ   1 
ATOM   1513 N  NH1  . ARG B 2 50  ? 16.494  -14.693 -76.489 1.00 118.86 ? 65  ARG H NH1  1 
ATOM   1514 N  NH2  . ARG B 2 50  ? 15.198  -16.308 -77.457 1.00 112.98 ? 65  ARG H NH2  1 
ATOM   1515 N  N    . ASN B 2 51  ? 15.019  -15.174 -71.548 1.00 59.35  ? 66  ASN H N    1 
ATOM   1516 C  CA   . ASN B 2 51  ? 15.724  -13.953 -71.192 1.00 65.62  ? 66  ASN H CA   1 
ATOM   1517 C  C    . ASN B 2 51  ? 15.883  -13.910 -69.673 1.00 57.31  ? 66  ASN H C    1 
ATOM   1518 O  O    . ASN B 2 51  ? 16.001  -12.829 -69.081 1.00 51.19  ? 66  ASN H O    1 
ATOM   1519 C  CB   . ASN B 2 51  ? 14.977  -12.726 -71.722 1.00 77.73  ? 66  ASN H CB   1 
ATOM   1520 C  CG   . ASN B 2 51  ? 15.036  -12.608 -73.230 1.00 87.90  ? 66  ASN H CG   1 
ATOM   1521 O  OD1  . ASN B 2 51  ? 15.911  -13.194 -73.872 1.00 82.04  ? 66  ASN H OD1  1 
ATOM   1522 N  ND2  . ASN B 2 51  ? 14.130  -11.824 -73.796 1.00 86.43  ? 66  ASN H ND2  1 
ATOM   1523 N  N    . LEU B 2 52  ? 15.890  -15.114 -69.079 1.00 42.34  ? 67  LEU H N    1 
ATOM   1524 C  CA   . LEU B 2 52  ? 15.608  -15.300 -67.672 1.00 39.62  ? 67  LEU H CA   1 
ATOM   1525 C  C    . LEU B 2 52  ? 16.832  -15.887 -66.987 1.00 33.50  ? 67  LEU H C    1 
ATOM   1526 O  O    . LEU B 2 52  ? 17.077  -17.091 -67.063 1.00 34.82  ? 67  LEU H O    1 
ATOM   1527 C  CB   . LEU B 2 52  ? 14.381  -16.208 -67.561 1.00 40.19  ? 67  LEU H CB   1 
ATOM   1528 C  CG   . LEU B 2 52  ? 13.925  -16.568 -66.155 1.00 41.38  ? 67  LEU H CG   1 
ATOM   1529 C  CD1  . LEU B 2 52  ? 13.800  -15.338 -65.273 1.00 42.92  ? 67  LEU H CD1  1 
ATOM   1530 C  CD2  . LEU B 2 52  ? 12.590  -17.292 -66.212 1.00 41.73  ? 67  LEU H CD2  1 
ATOM   1531 N  N    . ILE B 2 53  ? 17.580  -15.027 -66.294 1.00 27.29  ? 68  ILE H N    1 
ATOM   1532 C  CA   . ILE B 2 53  ? 18.853  -15.449 -65.729 1.00 29.71  ? 68  ILE H CA   1 
ATOM   1533 C  C    . ILE B 2 53  ? 18.798  -15.521 -64.192 1.00 27.52  ? 68  ILE H C    1 
ATOM   1534 O  O    . ILE B 2 53  ? 18.172  -14.692 -63.523 1.00 28.31  ? 68  ILE H O    1 
ATOM   1535 C  CB   . ILE B 2 53  ? 19.955  -14.522 -66.288 1.00 29.09  ? 68  ILE H CB   1 
ATOM   1536 C  CG1  . ILE B 2 53  ? 20.020  -14.696 -67.808 1.00 31.87  ? 68  ILE H CG1  1 
ATOM   1537 C  CG2  . ILE B 2 53  ? 21.300  -14.713 -65.615 1.00 28.43  ? 68  ILE H CG2  1 
ATOM   1538 C  CD1  . ILE B 2 53  ? 21.402  -14.877 -68.371 1.00 34.44  ? 68  ILE H CD1  1 
ATOM   1539 N  N    . ALA B 2 54  ? 19.533  -16.478 -63.612 1.00 24.18  ? 69  ALA H N    1 
ATOM   1540 C  CA   . ALA B 2 54  ? 19.745  -16.444 -62.171 1.00 24.39  ? 69  ALA H CA   1 
ATOM   1541 C  C    . ALA B 2 54  ? 21.148  -15.937 -61.870 1.00 24.42  ? 69  ALA H C    1 
ATOM   1542 O  O    . ALA B 2 54  ? 22.099  -16.403 -62.487 1.00 28.02  ? 69  ALA H O    1 
ATOM   1543 C  CB   . ALA B 2 54  ? 19.517  -17.812 -61.578 1.00 23.60  ? 69  ALA H CB   1 
ATOM   1544 N  N    . VAL B 2 55  ? 21.303  -15.064 -60.868 1.00 22.83  ? 70  VAL H N    1 
ATOM   1545 C  CA   . VAL B 2 55  ? 22.644  -14.643 -60.502 1.00 24.14  ? 70  VAL H CA   1 
ATOM   1546 C  C    . VAL B 2 55  ? 22.925  -15.040 -59.055 1.00 24.28  ? 70  VAL H C    1 
ATOM   1547 O  O    . VAL B 2 55  ? 22.182  -14.659 -58.162 1.00 25.34  ? 70  VAL H O    1 
ATOM   1548 C  CB   . VAL B 2 55  ? 22.856  -13.128 -60.691 1.00 24.67  ? 70  VAL H CB   1 
ATOM   1549 C  CG1  . VAL B 2 55  ? 24.315  -12.756 -60.478 1.00 27.10  ? 70  VAL H CG1  1 
ATOM   1550 C  CG2  . VAL B 2 55  ? 22.369  -12.628 -62.036 1.00 23.81  ? 70  VAL H CG2  1 
ATOM   1551 N  N    . LEU B 2 56  ? 24.058  -15.719 -58.834 1.00 22.78  ? 71  LEU H N    1 
ATOM   1552 C  CA   . LEU B 2 56  ? 24.480  -16.129 -57.510 1.00 22.16  ? 71  LEU H CA   1 
ATOM   1553 C  C    . LEU B 2 56  ? 25.798  -15.469 -57.143 1.00 21.69  ? 71  LEU H C    1 
ATOM   1554 O  O    . LEU B 2 56  ? 26.630  -15.161 -57.995 1.00 22.51  ? 71  LEU H O    1 
ATOM   1555 C  CB   . LEU B 2 56  ? 24.543  -17.656 -57.452 1.00 24.19  ? 71  LEU H CB   1 
ATOM   1556 C  CG   . LEU B 2 56  ? 23.157  -18.276 -57.235 1.00 28.17  ? 71  LEU H CG   1 
ATOM   1557 C  CD1  . LEU B 2 56  ? 22.617  -18.936 -58.486 1.00 32.28  ? 71  LEU H CD1  1 
ATOM   1558 C  CD2  . LEU B 2 56  ? 23.153  -19.247 -56.087 1.00 29.76  ? 71  LEU H CD2  1 
ATOM   1559 N  N    . GLY B 2 57  ? 25.943  -15.200 -55.847 1.00 22.49  ? 72  GLY H N    1 
ATOM   1560 C  CA   . GLY B 2 57  ? 27.114  -14.517 -55.318 1.00 21.90  ? 72  GLY H CA   1 
ATOM   1561 C  C    . GLY B 2 57  ? 27.059  -13.010 -55.531 1.00 21.35  ? 72  GLY H C    1 
ATOM   1562 O  O    . GLY B 2 57  ? 28.082  -12.354 -55.410 1.00 24.09  ? 72  GLY H O    1 
ATOM   1563 N  N    . GLU B 2 58  ? 25.868  -12.473 -55.838 1.00 21.09  ? 73  GLU H N    1 
ATOM   1564 C  CA   . GLU B 2 58  ? 25.672  -11.046 -56.020 1.00 20.31  ? 73  GLU H CA   1 
ATOM   1565 C  C    . GLU B 2 58  ? 25.733  -10.354 -54.662 1.00 20.07  ? 73  GLU H C    1 
ATOM   1566 O  O    . GLU B 2 58  ? 25.413  -10.939 -53.635 1.00 21.63  ? 73  GLU H O    1 
ATOM   1567 C  CB   . GLU B 2 58  ? 24.321  -10.811 -56.703 1.00 22.42  ? 73  GLU H CB   1 
ATOM   1568 C  CG   . GLU B 2 58  ? 24.026  -9.372  -57.135 1.00 21.90  ? 73  GLU H CG   1 
ATOM   1569 C  CD   . GLU B 2 58  ? 25.108  -8.705  -57.974 1.00 20.78  ? 73  GLU H CD   1 
ATOM   1570 O  OE1  . GLU B 2 58  ? 24.984  -8.667  -59.233 1.00 21.22  ? 73  GLU H OE1  1 
ATOM   1571 O  OE2  . GLU B 2 58  ? 26.075  -8.224  -57.374 1.00 18.33  ? 73  GLU H OE2  1 
ATOM   1572 N  N    . HIS B 2 59  ? 26.154  -9.093  -54.654 1.00 19.17  ? 74  HIS H N    1 
ATOM   1573 C  CA   . HIS B 2 59  ? 26.153  -8.300  -53.442 1.00 18.77  ? 74  HIS H CA   1 
ATOM   1574 C  C    . HIS B 2 59  ? 25.775  -6.883  -53.824 1.00 18.16  ? 74  HIS H C    1 
ATOM   1575 O  O    . HIS B 2 59  ? 24.764  -6.356  -53.371 1.00 16.60  ? 74  HIS H O    1 
ATOM   1576 C  CB   . HIS B 2 59  ? 27.493  -8.399  -52.697 1.00 18.26  ? 74  HIS H CB   1 
ATOM   1577 C  CG   . HIS B 2 59  ? 27.563  -7.452  -51.576 1.00 19.12  ? 74  HIS H CG   1 
ATOM   1578 N  ND1  . HIS B 2 59  ? 26.793  -7.584  -50.451 1.00 21.06  ? 74  HIS H ND1  1 
ATOM   1579 C  CD2  . HIS B 2 59  ? 28.207  -6.297  -51.445 1.00 21.18  ? 74  HIS H CD2  1 
ATOM   1580 C  CE1  . HIS B 2 59  ? 26.985  -6.532  -49.668 1.00 20.22  ? 74  HIS H CE1  1 
ATOM   1581 N  NE2  . HIS B 2 59  ? 27.843  -5.738  -50.250 1.00 19.64  ? 74  HIS H NE2  1 
ATOM   1582 N  N    . ASP B 2 60  ? 26.652  -6.272  -54.610 1.00 21.34  ? 75  ASP H N    1 
ATOM   1583 C  CA   . ASP B 2 60  ? 26.488  -4.896  -55.046 1.00 24.08  ? 75  ASP H CA   1 
ATOM   1584 C  C    . ASP B 2 60  ? 26.094  -4.993  -56.513 1.00 23.16  ? 75  ASP H C    1 
ATOM   1585 O  O    . ASP B 2 60  ? 26.898  -5.481  -57.294 1.00 23.36  ? 75  ASP H O    1 
ATOM   1586 C  CB   . ASP B 2 60  ? 27.778  -4.098  -54.776 1.00 25.47  ? 75  ASP H CB   1 
ATOM   1587 C  CG   . ASP B 2 60  ? 27.774  -2.613  -55.148 1.00 26.33  ? 75  ASP H CG   1 
ATOM   1588 O  OD1  . ASP B 2 60  ? 26.944  -2.195  -55.976 1.00 24.96  ? 75  ASP H OD1  1 
ATOM   1589 O  OD2  . ASP B 2 60  ? 28.594  -1.866  -54.571 1.00 26.44  ? 75  ASP H OD2  1 
ATOM   1590 N  N    . LEU B 2 61  ? 24.871  -4.570  -56.850 1.00 23.49  ? 76  LEU H N    1 
ATOM   1591 C  CA   . LEU B 2 61  ? 24.352  -4.678  -58.212 1.00 27.03  ? 76  LEU H CA   1 
ATOM   1592 C  C    . LEU B 2 61  ? 25.099  -3.758  -59.163 1.00 24.25  ? 76  LEU H C    1 
ATOM   1593 O  O    . LEU B 2 61  ? 24.985  -3.902  -60.373 1.00 25.57  ? 76  LEU H O    1 
ATOM   1594 C  CB   . LEU B 2 61  ? 22.879  -4.276  -58.272 1.00 29.99  ? 76  LEU H CB   1 
ATOM   1595 C  CG   . LEU B 2 61  ? 21.928  -5.081  -57.400 1.00 33.51  ? 76  LEU H CG   1 
ATOM   1596 C  CD1  . LEU B 2 61  ? 20.504  -4.638  -57.689 1.00 35.14  ? 76  LEU H CD1  1 
ATOM   1597 C  CD2  . LEU B 2 61  ? 22.099  -6.570  -57.649 1.00 34.60  ? 76  LEU H CD2  1 
ATOM   1598 N  N    . SER B 2 62  ? 25.817  -2.798  -58.607 1.00 24.16  ? 77  SER H N    1 
ATOM   1599 C  CA   . SER B 2 62  ? 26.456  -1.777  -59.404 1.00 25.66  ? 77  SER H CA   1 
ATOM   1600 C  C    . SER B 2 62  ? 27.922  -2.104  -59.722 1.00 27.02  ? 77  SER H C    1 
ATOM   1601 O  O    . SER B 2 62  ? 28.480  -1.370  -60.509 1.00 26.88  ? 77  SER H O    1 
ATOM   1602 C  CB   . SER B 2 62  ? 26.326  -0.470  -58.721 1.00 25.28  ? 77  SER H CB   1 
ATOM   1603 O  OG   . SER B 2 62  ? 27.166  -0.443  -57.579 1.00 28.68  ? 77  SER H OG   1 
ATOM   1604 N  N    . GLU B 2 63  ? 28.554  -3.150  -59.142 1.00 29.50  ? 78  GLU H N    1 
ATOM   1605 C  CA   . GLU B 2 63  ? 29.886  -3.573  -59.571 1.00 33.77  ? 78  GLU H CA   1 
ATOM   1606 C  C    . GLU B 2 63  ? 29.915  -5.079  -59.766 1.00 35.94  ? 78  GLU H C    1 
ATOM   1607 O  O    . GLU B 2 63  ? 29.380  -5.810  -58.946 1.00 40.21  ? 78  GLU H O    1 
ATOM   1608 C  CB   . GLU B 2 63  ? 31.023  -3.134  -58.637 1.00 38.72  ? 78  GLU H CB   1 
ATOM   1609 C  CG   . GLU B 2 63  ? 31.036  -3.773  -57.257 1.00 51.21  ? 78  GLU H CG   1 
ATOM   1610 C  CD   . GLU B 2 63  ? 32.185  -3.385  -56.321 1.00 62.35  ? 78  GLU H CD   1 
ATOM   1611 O  OE1  . GLU B 2 63  ? 33.236  -2.886  -56.814 1.00 55.58  ? 78  GLU H OE1  1 
ATOM   1612 O  OE2  . GLU B 2 63  ? 32.032  -3.571  -55.075 1.00 63.15  ? 78  GLU H OE2  1 
ATOM   1613 N  N    . HIS B 2 64  ? 30.542  -5.538  -60.858 1.00 39.72  ? 79  HIS H N    1 
ATOM   1614 C  CA   . HIS B 2 64  ? 30.712  -6.966  -61.106 1.00 41.81  ? 79  HIS H CA   1 
ATOM   1615 C  C    . HIS B 2 64  ? 32.057  -7.416  -60.549 1.00 37.35  ? 79  HIS H C    1 
ATOM   1616 O  O    . HIS B 2 64  ? 33.074  -6.907  -60.987 1.00 44.75  ? 79  HIS H O    1 
ATOM   1617 C  CB   . HIS B 2 64  ? 30.593  -7.286  -62.601 1.00 43.34  ? 79  HIS H CB   1 
ATOM   1618 C  CG   . HIS B 2 64  ? 29.198  -7.165  -63.152 1.00 48.05  ? 79  HIS H CG   1 
ATOM   1619 N  ND1  . HIS B 2 64  ? 28.228  -8.136  -62.984 1.00 52.38  ? 79  HIS H ND1  1 
ATOM   1620 C  CD2  . HIS B 2 64  ? 28.619  -6.206  -63.901 1.00 47.78  ? 79  HIS H CD2  1 
ATOM   1621 C  CE1  . HIS B 2 64  ? 27.106  -7.760  -63.594 1.00 49.88  ? 79  HIS H CE1  1 
ATOM   1622 N  NE2  . HIS B 2 64  ? 27.326  -6.596  -64.168 1.00 48.65  ? 79  HIS H NE2  1 
ATOM   1623 N  N    . ASP B 2 65  ? 32.062  -8.337  -59.575 1.00 34.72  ? 80  ASP H N    1 
ATOM   1624 C  CA   . ASP B 2 65  ? 33.309  -8.898  -59.061 1.00 31.36  ? 80  ASP H CA   1 
ATOM   1625 C  C    . ASP B 2 65  ? 33.365  -10.403 -59.356 1.00 31.07  ? 80  ASP H C    1 
ATOM   1626 O  O    . ASP B 2 65  ? 32.418  -10.995 -59.866 1.00 33.66  ? 80  ASP H O    1 
ATOM   1627 C  CB   . ASP B 2 65  ? 33.507  -8.533  -57.585 1.00 29.42  ? 80  ASP H CB   1 
ATOM   1628 C  CG   . ASP B 2 65  ? 32.562  -9.233  -56.628 1.00 25.62  ? 80  ASP H CG   1 
ATOM   1629 O  OD1  . ASP B 2 65  ? 32.019  -10.247 -57.008 1.00 24.61  ? 80  ASP H OD1  1 
ATOM   1630 O  OD2  . ASP B 2 65  ? 32.409  -8.757  -55.493 1.00 28.32  ? 80  ASP H OD2  1 
ATOM   1631 N  N    . GLY B 2 66  ? 34.486  -11.037 -59.019 1.00 30.48  ? 81  GLY H N    1 
ATOM   1632 C  CA   . GLY B 2 66  ? 34.707  -12.421 -59.399 1.00 30.07  ? 81  GLY H CA   1 
ATOM   1633 C  C    . GLY B 2 66  ? 33.832  -13.422 -58.651 1.00 28.41  ? 81  GLY H C    1 
ATOM   1634 O  O    . GLY B 2 66  ? 33.910  -14.626 -58.895 1.00 27.16  ? 81  GLY H O    1 
ATOM   1635 N  N    . ASP B 2 67  ? 32.991  -12.952 -57.731 1.00 30.96  ? 82  ASP H N    1 
ATOM   1636 C  CA   . ASP B 2 67  ? 32.162  -13.896 -56.983 1.00 30.31  ? 82  ASP H CA   1 
ATOM   1637 C  C    . ASP B 2 67  ? 30.819  -14.148 -57.670 1.00 28.48  ? 82  ASP H C    1 
ATOM   1638 O  O    . ASP B 2 67  ? 30.165  -15.121 -57.324 1.00 30.85  ? 82  ASP H O    1 
ATOM   1639 C  CB   . ASP B 2 67  ? 32.000  -13.456 -55.535 1.00 27.40  ? 82  ASP H CB   1 
ATOM   1640 C  CG   . ASP B 2 67  ? 33.349  -13.415 -54.846 1.00 31.57  ? 82  ASP H CG   1 
ATOM   1641 O  OD1  . ASP B 2 67  ? 34.181  -14.348 -55.094 1.00 28.64  ? 82  ASP H OD1  1 
ATOM   1642 O  OD2  . ASP B 2 67  ? 33.571  -12.442 -54.084 1.00 35.79  ? 82  ASP H OD2  1 
ATOM   1643 N  N    . GLU B 2 68  ? 30.421  -13.310 -58.636 1.00 25.22  ? 83  GLU H N    1 
ATOM   1644 C  CA   . GLU B 2 68  ? 29.150  -13.498 -59.307 1.00 26.09  ? 83  GLU H CA   1 
ATOM   1645 C  C    . GLU B 2 68  ? 29.210  -14.680 -60.266 1.00 23.40  ? 83  GLU H C    1 
ATOM   1646 O  O    . GLU B 2 68  ? 30.123  -14.757 -61.057 1.00 22.38  ? 83  GLU H O    1 
ATOM   1647 C  CB   . GLU B 2 68  ? 28.796  -12.204 -60.023 1.00 27.15  ? 83  GLU H CB   1 
ATOM   1648 C  CG   . GLU B 2 68  ? 28.474  -11.130 -59.022 1.00 29.15  ? 83  GLU H CG   1 
ATOM   1649 C  CD   . GLU B 2 68  ? 28.649  -9.723  -59.522 1.00 30.26  ? 83  GLU H CD   1 
ATOM   1650 O  OE1  . GLU B 2 68  ? 28.133  -9.446  -60.613 1.00 36.78  ? 83  GLU H OE1  1 
ATOM   1651 O  OE2  . GLU B 2 68  ? 29.270  -8.916  -58.799 1.00 33.84  ? 83  GLU H OE2  1 
ATOM   1652 N  N    . GLN B 2 69  ? 28.246  -15.610 -60.171 1.00 23.12  ? 84  GLN H N    1 
ATOM   1653 C  CA   . GLN B 2 69  ? 28.024  -16.597 -61.224 1.00 21.99  ? 84  GLN H CA   1 
ATOM   1654 C  C    . GLN B 2 69  ? 26.632  -16.422 -61.821 1.00 21.80  ? 84  GLN H C    1 
ATOM   1655 O  O    . GLN B 2 69  ? 25.678  -16.180 -61.098 1.00 23.92  ? 84  GLN H O    1 
ATOM   1656 C  CB   . GLN B 2 69  ? 28.143  -18.024 -60.701 1.00 20.04  ? 84  GLN H CB   1 
ATOM   1657 C  CG   . GLN B 2 69  ? 29.442  -18.298 -59.980 1.00 19.66  ? 84  GLN H CG   1 
ATOM   1658 C  CD   . GLN B 2 69  ? 29.475  -19.687 -59.392 1.00 19.56  ? 84  GLN H CD   1 
ATOM   1659 O  OE1  . GLN B 2 69  ? 29.301  -20.685 -60.084 1.00 19.85  ? 84  GLN H OE1  1 
ATOM   1660 N  NE2  . GLN B 2 69  ? 29.725  -19.775 -58.096 1.00 21.92  ? 84  GLN H NE2  1 
ATOM   1661 N  N    . SER B 2 70  ? 26.531  -16.524 -63.147 1.00 24.87  ? 85  SER H N    1 
ATOM   1662 C  CA   . SER B 2 70  ? 25.265  -16.451 -63.861 1.00 26.61  ? 85  SER H CA   1 
ATOM   1663 C  C    . SER B 2 70  ? 24.874  -17.835 -64.368 1.00 24.67  ? 85  SER H C    1 
ATOM   1664 O  O    . SER B 2 70  ? 25.736  -18.643 -64.686 1.00 24.24  ? 85  SER H O    1 
ATOM   1665 C  CB   . SER B 2 70  ? 25.340  -15.476 -64.996 1.00 31.10  ? 85  SER H CB   1 
ATOM   1666 O  OG   . SER B 2 70  ? 24.969  -14.169 -64.584 1.00 35.49  ? 85  SER H OG   1 
ATOM   1667 N  N    . ARG B 2 71  ? 23.569  -18.108 -64.401 1.00 22.80  ? 86  ARG H N    1 
ATOM   1668 C  CA   . ARG B 2 71  ? 23.039  -19.297 -65.029 1.00 22.88  ? 86  ARG H CA   1 
ATOM   1669 C  C    . ARG B 2 71  ? 21.687  -18.971 -65.651 1.00 26.49  ? 86  ARG H C    1 
ATOM   1670 O  O    . ARG B 2 71  ? 20.898  -18.194 -65.116 1.00 26.63  ? 86  ARG H O    1 
ATOM   1671 C  CB   . ARG B 2 71  ? 22.867  -20.460 -64.050 1.00 24.20  ? 86  ARG H CB   1 
ATOM   1672 C  CG   . ARG B 2 71  ? 24.152  -21.012 -63.440 1.00 25.69  ? 86  ARG H CG   1 
ATOM   1673 C  CD   . ARG B 2 71  ? 25.082  -21.636 -64.458 1.00 24.93  ? 86  ARG H CD   1 
ATOM   1674 N  NE   . ARG B 2 71  ? 26.245  -22.263 -63.865 1.00 24.25  ? 86  ARG H NE   1 
ATOM   1675 C  CZ   . ARG B 2 71  ? 27.361  -21.633 -63.523 1.00 26.26  ? 86  ARG H CZ   1 
ATOM   1676 N  NH1  . ARG B 2 71  ? 27.514  -20.335 -63.760 1.00 26.36  ? 86  ARG H NH1  1 
ATOM   1677 N  NH2  . ARG B 2 71  ? 28.325  -22.314 -62.928 1.00 25.78  ? 86  ARG H NH2  1 
ATOM   1678 N  N    . ARG B 2 72  ? 21.462  -19.613 -66.794 1.00 32.68  ? 87  ARG H N    1 
ATOM   1679 C  CA   . ARG B 2 72  ? 20.205  -19.643 -67.507 1.00 39.56  ? 87  ARG H CA   1 
ATOM   1680 C  C    . ARG B 2 72  ? 19.252  -20.535 -66.722 1.00 32.25  ? 87  ARG H C    1 
ATOM   1681 O  O    . ARG B 2 72  ? 19.627  -21.593 -66.242 1.00 26.72  ? 87  ARG H O    1 
ATOM   1682 C  CB   . ARG B 2 72  ? 20.460  -20.127 -68.946 1.00 52.71  ? 87  ARG H CB   1 
ATOM   1683 C  CG   . ARG B 2 72  ? 19.338  -20.960 -69.563 1.00 78.21  ? 87  ARG H CG   1 
ATOM   1684 C  CD   . ARG B 2 72  ? 18.383  -20.261 -70.527 1.00 92.96  ? 87  ARG H CD   1 
ATOM   1685 N  NE   . ARG B 2 72  ? 18.161  -18.860 -70.192 1.00 106.57 ? 87  ARG H NE   1 
ATOM   1686 C  CZ   . ARG B 2 72  ? 18.738  -17.826 -70.801 1.00 110.47 ? 87  ARG H CZ   1 
ATOM   1687 N  NH1  . ARG B 2 72  ? 19.550  -18.003 -71.830 1.00 97.31  ? 87  ARG H NH1  1 
ATOM   1688 N  NH2  . ARG B 2 72  ? 18.503  -16.599 -70.367 1.00 125.00 ? 87  ARG H NH2  1 
ATOM   1689 N  N    . VAL B 2 73  ? 18.007  -20.082 -66.589 1.00 32.20  ? 88  VAL H N    1 
ATOM   1690 C  CA   . VAL B 2 73  ? 16.979  -20.914 -65.995 1.00 30.94  ? 88  VAL H CA   1 
ATOM   1691 C  C    . VAL B 2 73  ? 16.421  -21.839 -67.073 1.00 28.61  ? 88  VAL H C    1 
ATOM   1692 O  O    . VAL B 2 73  ? 15.905  -21.401 -68.097 1.00 29.63  ? 88  VAL H O    1 
ATOM   1693 C  CB   . VAL B 2 73  ? 15.891  -20.062 -65.334 1.00 28.94  ? 88  VAL H CB   1 
ATOM   1694 C  CG1  . VAL B 2 73  ? 14.822  -20.939 -64.709 1.00 33.10  ? 88  VAL H CG1  1 
ATOM   1695 C  CG2  . VAL B 2 73  ? 16.477  -19.130 -64.292 1.00 28.61  ? 88  VAL H CG2  1 
ATOM   1696 N  N    . ALA B 2 74  ? 16.576  -23.134 -66.841 1.00 27.73  ? 89  ALA H N    1 
ATOM   1697 C  CA   . ALA B 2 74  ? 16.092  -24.136 -67.771 1.00 29.42  ? 89  ALA H CA   1 
ATOM   1698 C  C    . ALA B 2 74  ? 14.583  -24.342 -67.611 1.00 31.68  ? 89  ALA H C    1 
ATOM   1699 O  O    . ALA B 2 74  ? 13.873  -24.508 -68.597 1.00 33.01  ? 89  ALA H O    1 
ATOM   1700 C  CB   . ALA B 2 74  ? 16.867  -25.406 -67.557 1.00 30.15  ? 89  ALA H CB   1 
ATOM   1701 N  N    . GLN B 2 75  ? 14.069  -24.278 -66.377 1.00 33.02  ? 90  GLN H N    1 
ATOM   1702 C  CA   . GLN B 2 75  ? 12.672  -24.617 -66.146 1.00 31.93  ? 90  GLN H CA   1 
ATOM   1703 C  C    . GLN B 2 75  ? 12.093  -23.920 -64.904 1.00 28.29  ? 90  GLN H C    1 
ATOM   1704 O  O    . GLN B 2 75  ? 12.736  -23.786 -63.871 1.00 27.10  ? 90  GLN H O    1 
ATOM   1705 C  CB   . GLN B 2 75  ? 12.594  -26.142 -66.088 1.00 33.57  ? 90  GLN H CB   1 
ATOM   1706 C  CG   . GLN B 2 75  ? 11.225  -26.683 -65.741 1.00 38.71  ? 90  GLN H CG   1 
ATOM   1707 C  CD   . GLN B 2 75  ? 11.052  -28.094 -66.235 1.00 40.99  ? 90  GLN H CD   1 
ATOM   1708 O  OE1  . GLN B 2 75  ? 11.750  -29.010 -65.802 1.00 40.98  ? 90  GLN H OE1  1 
ATOM   1709 N  NE2  . GLN B 2 75  ? 10.130  -28.255 -67.171 1.00 45.59  ? 90  GLN H NE2  1 
ATOM   1710 N  N    . VAL B 2 76  ? 10.819  -23.552 -64.992 1.00 26.18  ? 91  VAL H N    1 
ATOM   1711 C  CA   . VAL B 2 76  ? 10.101  -22.940 -63.893 1.00 26.48  ? 91  VAL H CA   1 
ATOM   1712 C  C    . VAL B 2 76  ? 8.910   -23.825 -63.551 1.00 28.00  ? 91  VAL H C    1 
ATOM   1713 O  O    . VAL B 2 76  ? 8.008   -23.963 -64.374 1.00 29.15  ? 91  VAL H O    1 
ATOM   1714 C  CB   . VAL B 2 76  ? 9.595   -21.542 -64.279 1.00 24.66  ? 91  VAL H CB   1 
ATOM   1715 C  CG1  . VAL B 2 76  ? 8.785   -20.917 -63.160 1.00 24.07  ? 91  VAL H CG1  1 
ATOM   1716 C  CG2  . VAL B 2 76  ? 10.728  -20.636 -64.712 1.00 25.21  ? 91  VAL H CG2  1 
ATOM   1717 N  N    . ILE B 2 77  ? 8.874   -24.358 -62.326 1.00 25.37  ? 92  ILE H N    1 
ATOM   1718 C  CA   . ILE B 2 77  ? 7.803   -25.257 -61.942 1.00 23.76  ? 92  ILE H CA   1 
ATOM   1719 C  C    . ILE B 2 77  ? 6.950   -24.610 -60.848 1.00 25.84  ? 92  ILE H C    1 
ATOM   1720 O  O    . ILE B 2 77  ? 7.437   -24.277 -59.767 1.00 25.86  ? 92  ILE H O    1 
ATOM   1721 C  CB   . ILE B 2 77  ? 8.357   -26.619 -61.498 1.00 23.18  ? 92  ILE H CB   1 
ATOM   1722 C  CG1  . ILE B 2 77  ? 9.438   -27.128 -62.453 1.00 23.28  ? 92  ILE H CG1  1 
ATOM   1723 C  CG2  . ILE B 2 77  ? 7.212   -27.614 -61.322 1.00 25.70  ? 92  ILE H CG2  1 
ATOM   1724 C  CD1  . ILE B 2 77  ? 10.128  -28.405 -62.002 1.00 22.34  ? 92  ILE H CD1  1 
ATOM   1725 N  N    . ILE B 2 78  ? 5.645   -24.501 -61.123 1.00 26.32  ? 93  ILE H N    1 
ATOM   1726 C  CA   . ILE B 2 78  ? 4.710   -23.896 -60.194 1.00 27.22  ? 93  ILE H CA   1 
ATOM   1727 C  C    . ILE B 2 78  ? 3.580   -24.886 -59.932 1.00 27.34  ? 93  ILE H C    1 
ATOM   1728 O  O    . ILE B 2 78  ? 3.371   -25.815 -60.698 1.00 31.07  ? 93  ILE H O    1 
ATOM   1729 C  CB   . ILE B 2 78  ? 4.217   -22.543 -60.740 1.00 27.77  ? 93  ILE H CB   1 
ATOM   1730 C  CG1  . ILE B 2 78  ? 3.411   -22.683 -62.030 1.00 29.09  ? 93  ILE H CG1  1 
ATOM   1731 C  CG2  . ILE B 2 78  ? 5.390   -21.603 -60.946 1.00 28.10  ? 93  ILE H CG2  1 
ATOM   1732 C  CD1  . ILE B 2 78  ? 2.777   -21.388 -62.504 1.00 29.81  ? 93  ILE H CD1  1 
ATOM   1733 N  N    . PRO B 2 79  ? 2.822   -24.744 -58.829 1.00 27.31  ? 94  PRO H N    1 
ATOM   1734 C  CA   . PRO B 2 79  ? 1.614   -25.543 -58.624 1.00 27.17  ? 94  PRO H CA   1 
ATOM   1735 C  C    . PRO B 2 79  ? 0.492   -25.281 -59.627 1.00 24.18  ? 94  PRO H C    1 
ATOM   1736 O  O    . PRO B 2 79  ? 0.241   -24.141 -60.012 1.00 26.70  ? 94  PRO H O    1 
ATOM   1737 C  CB   . PRO B 2 79  ? 1.139   -25.076 -57.242 1.00 26.62  ? 94  PRO H CB   1 
ATOM   1738 C  CG   . PRO B 2 79  ? 2.366   -24.520 -56.590 1.00 26.01  ? 94  PRO H CG   1 
ATOM   1739 C  CD   . PRO B 2 79  ? 3.082   -23.826 -57.717 1.00 26.76  ? 94  PRO H CD   1 
ATOM   1740 N  N    . SER B 2 80  ? -0.234  -26.337 -59.976 1.00 23.42  ? 95  SER H N    1 
ATOM   1741 C  CA   . SER B 2 80  ? -1.429  -26.219 -60.810 1.00 25.23  ? 95  SER H CA   1 
ATOM   1742 C  C    . SER B 2 80  ? -2.503  -25.413 -60.094 1.00 24.15  ? 95  SER H C    1 
ATOM   1743 O  O    . SER B 2 80  ? -3.298  -24.744 -60.747 1.00 26.81  ? 95  SER H O    1 
ATOM   1744 C  CB   . SER B 2 80  ? -1.982  -27.566 -61.185 1.00 27.63  ? 95  SER H CB   1 
ATOM   1745 O  OG   . SER B 2 80  ? -2.278  -28.325 -60.001 1.00 31.58  ? 95  SER H OG   1 
ATOM   1746 N  N    . THR B 2 81  ? -2.499  -25.466 -58.754 1.00 22.97  ? 96  THR H N    1 
ATOM   1747 C  CA   . THR B 2 81  ? -3.454  -24.774 -57.904 1.00 21.31  ? 96  THR H CA   1 
ATOM   1748 C  C    . THR B 2 81  ? -3.207  -23.274 -57.819 1.00 20.50  ? 96  THR H C    1 
ATOM   1749 O  O    . THR B 2 81  ? -4.034  -22.540 -57.309 1.00 20.44  ? 96  THR H O    1 
ATOM   1750 C  CB   . THR B 2 81  ? -3.363  -25.351 -56.502 1.00 24.04  ? 96  THR H CB   1 
ATOM   1751 O  OG1  . THR B 2 81  ? -1.971  -25.310 -56.167 1.00 25.96  ? 96  THR H OG1  1 
ATOM   1752 C  CG2  . THR B 2 81  ? -3.889  -26.769 -56.448 1.00 24.13  ? 96  THR H CG2  1 
ATOM   1753 N  N    . TYR B 2 82  ? -2.071  -22.793 -58.306 1.00 21.24  ? 97  TYR H N    1 
ATOM   1754 C  CA   . TYR B 2 82  ? -1.796  -21.370 -58.231 1.00 20.46  ? 97  TYR H CA   1 
ATOM   1755 C  C    . TYR B 2 82  ? -2.594  -20.644 -59.312 1.00 21.04  ? 97  TYR H C    1 
ATOM   1756 O  O    . TYR B 2 82  ? -2.767  -21.151 -60.405 1.00 20.67  ? 97  TYR H O    1 
ATOM   1757 C  CB   . TYR B 2 82  ? -0.299  -21.093 -58.413 1.00 18.72  ? 97  TYR H CB   1 
ATOM   1758 C  CG   . TYR B 2 82  ? 0.001   -19.622 -58.625 1.00 16.71  ? 97  TYR H CG   1 
ATOM   1759 C  CD1  . TYR B 2 82  ? -0.023  -18.728 -57.572 1.00 16.85  ? 97  TYR H CD1  1 
ATOM   1760 C  CD2  . TYR B 2 82  ? 0.280   -19.126 -59.882 1.00 16.59  ? 97  TYR H CD2  1 
ATOM   1761 C  CE1  . TYR B 2 82  ? 0.262   -17.385 -57.757 1.00 16.56  ? 97  TYR H CE1  1 
ATOM   1762 C  CE2  . TYR B 2 82  ? 0.604   -17.795 -60.078 1.00 16.10  ? 97  TYR H CE2  1 
ATOM   1763 C  CZ   . TYR B 2 82  ? 0.576   -16.922 -59.019 1.00 15.72  ? 97  TYR H CZ   1 
ATOM   1764 O  OH   . TYR B 2 82  ? 0.834   -15.615 -59.251 1.00 17.09  ? 97  TYR H OH   1 
ATOM   1765 N  N    . VAL B 2 83  ? -3.004  -19.410 -59.018 1.00 21.97  ? 98  VAL H N    1 
ATOM   1766 C  CA   . VAL B 2 83  ? -3.831  -18.654 -59.926 1.00 22.71  ? 98  VAL H CA   1 
ATOM   1767 C  C    . VAL B 2 83  ? -3.262  -17.247 -60.053 1.00 23.70  ? 98  VAL H C    1 
ATOM   1768 O  O    . VAL B 2 83  ? -3.336  -16.482 -59.095 1.00 24.25  ? 98  VAL H O    1 
ATOM   1769 C  CB   . VAL B 2 83  ? -5.283  -18.621 -59.426 1.00 23.89  ? 98  VAL H CB   1 
ATOM   1770 C  CG1  . VAL B 2 83  ? -6.148  -17.736 -60.317 1.00 26.08  ? 98  VAL H CG1  1 
ATOM   1771 C  CG2  . VAL B 2 83  ? -5.872  -20.020 -59.295 1.00 22.39  ? 98  VAL H CG2  1 
ATOM   1772 N  N    . PRO B 2 84  ? -2.703  -16.864 -61.233 1.00 24.32  ? 99  PRO H N    1 
ATOM   1773 C  CA   . PRO B 2 84  ? -2.172  -15.510 -61.447 1.00 23.21  ? 99  PRO H CA   1 
ATOM   1774 C  C    . PRO B 2 84  ? -3.107  -14.418 -60.955 1.00 23.69  ? 99  PRO H C    1 
ATOM   1775 O  O    . PRO B 2 84  ? -4.320  -14.486 -61.123 1.00 22.70  ? 99  PRO H O    1 
ATOM   1776 C  CB   . PRO B 2 84  ? -1.995  -15.428 -62.966 1.00 22.16  ? 99  PRO H CB   1 
ATOM   1777 C  CG   . PRO B 2 84  ? -1.670  -16.875 -63.351 1.00 23.37  ? 99  PRO H CG   1 
ATOM   1778 C  CD   . PRO B 2 84  ? -2.499  -17.731 -62.411 1.00 23.27  ? 99  PRO H CD   1 
ATOM   1779 N  N    . GLY B 2 85  ? -2.511  -13.433 -60.291 1.00 27.83  ? 100 GLY H N    1 
ATOM   1780 C  CA   . GLY B 2 85  ? -3.245  -12.314 -59.728 1.00 28.56  ? 100 GLY H CA   1 
ATOM   1781 C  C    . GLY B 2 85  ? -3.799  -12.605 -58.337 1.00 28.03  ? 100 GLY H C    1 
ATOM   1782 O  O    . GLY B 2 85  ? -4.457  -11.729 -57.790 1.00 32.42  ? 100 GLY H O    1 
ATOM   1783 N  N    . THR B 2 86  ? -3.578  -13.818 -57.808 1.00 26.41  ? 101 THR H N    1 
ATOM   1784 C  CA   . THR B 2 86  ? -3.909  -14.149 -56.428 1.00 27.73  ? 101 THR H CA   1 
ATOM   1785 C  C    . THR B 2 86  ? -2.617  -14.320 -55.638 1.00 26.41  ? 101 THR H C    1 
ATOM   1786 O  O    . THR B 2 86  ? -1.533  -14.091 -56.161 1.00 34.19  ? 101 THR H O    1 
ATOM   1787 C  CB   . THR B 2 86  ? -4.758  -15.427 -56.311 1.00 30.35  ? 101 THR H CB   1 
ATOM   1788 O  OG1  . THR B 2 86  ? -3.924  -16.558 -56.596 1.00 34.78  ? 101 THR H OG1  1 
ATOM   1789 C  CG2  . THR B 2 86  ? -5.967  -15.408 -57.217 1.00 31.38  ? 101 THR H CG2  1 
ATOM   1790 N  N    . THR B 2 87  ? -2.752  -14.779 -54.390 1.00 24.58  ? 102 THR H N    1 
ATOM   1791 C  CA   . THR B 2 87  ? -1.661  -14.841 -53.439 1.00 22.32  ? 102 THR H CA   1 
ATOM   1792 C  C    . THR B 2 87  ? -1.396  -16.258 -52.931 1.00 20.86  ? 102 THR H C    1 
ATOM   1793 O  O    . THR B 2 87  ? -0.344  -16.485 -52.350 1.00 21.20  ? 102 THR H O    1 
ATOM   1794 C  CB   . THR B 2 87  ? -1.957  -13.892 -52.270 1.00 23.03  ? 102 THR H CB   1 
ATOM   1795 O  OG1  . THR B 2 87  ? -3.231  -14.227 -51.713 1.00 22.78  ? 102 THR H OG1  1 
ATOM   1796 C  CG2  . THR B 2 87  ? -1.934  -12.434 -52.683 1.00 22.74  ? 102 THR H CG2  1 
ATOM   1797 N  N    . ASN B 2 88  ? -2.344  -17.196 -53.088 1.00 20.95  ? 103 ASN H N    1 
ATOM   1798 C  CA   . ASN B 2 88  ? -2.209  -18.521 -52.491 1.00 20.87  ? 103 ASN H CA   1 
ATOM   1799 C  C    . ASN B 2 88  ? -1.239  -19.391 -53.304 1.00 19.80  ? 103 ASN H C    1 
ATOM   1800 O  O    . ASN B 2 88  ? -1.013  -19.180 -54.490 1.00 22.73  ? 103 ASN H O    1 
ATOM   1801 C  CB   . ASN B 2 88  ? -3.585  -19.171 -52.326 1.00 20.99  ? 103 ASN H CB   1 
ATOM   1802 C  CG   . ASN B 2 88  ? -3.645  -20.207 -51.220 1.00 22.55  ? 103 ASN H CG   1 
ATOM   1803 O  OD1  . ASN B 2 88  ? -2.842  -20.202 -50.286 1.00 22.45  ? 103 ASN H OD1  1 
ATOM   1804 N  ND2  . ASN B 2 88  ? -4.641  -21.077 -51.277 1.00 22.71  ? 103 ASN H ND2  1 
ATOM   1805 N  N    . HIS B 2 89  ? -0.655  -20.404 -52.682 1.00 19.19  ? 104 HIS H N    1 
ATOM   1806 C  CA   . HIS B 2 89  ? 0.261   -21.315 -53.381 1.00 21.50  ? 104 HIS H CA   1 
ATOM   1807 C  C    . HIS B 2 89  ? 1.399   -20.586 -54.108 1.00 20.12  ? 104 HIS H C    1 
ATOM   1808 O  O    . HIS B 2 89  ? 1.760   -20.957 -55.206 1.00 18.84  ? 104 HIS H O    1 
ATOM   1809 C  CB   . HIS B 2 89  ? -0.500  -22.232 -54.347 1.00 22.07  ? 104 HIS H CB   1 
ATOM   1810 C  CG   . HIS B 2 89  ? -1.440  -23.122 -53.619 1.00 22.43  ? 104 HIS H CG   1 
ATOM   1811 N  ND1  . HIS B 2 89  ? -0.997  -24.210 -52.903 1.00 21.30  ? 104 HIS H ND1  1 
ATOM   1812 C  CD2  . HIS B 2 89  ? -2.766  -23.097 -53.498 1.00 22.31  ? 104 HIS H CD2  1 
ATOM   1813 C  CE1  . HIS B 2 89  ? -2.034  -24.815 -52.354 1.00 21.69  ? 104 HIS H CE1  1 
ATOM   1814 N  NE2  . HIS B 2 89  ? -3.113  -24.141 -52.690 1.00 23.89  ? 104 HIS H NE2  1 
ATOM   1815 N  N    . ASP B 2 90  ? 1.998   -19.586 -53.461 1.00 19.93  ? 105 ASP H N    1 
ATOM   1816 C  CA   . ASP B 2 90  ? 2.893   -18.663 -54.120 1.00 19.28  ? 105 ASP H CA   1 
ATOM   1817 C  C    . ASP B 2 90  ? 4.329   -19.155 -53.978 1.00 20.37  ? 105 ASP H C    1 
ATOM   1818 O  O    . ASP B 2 90  ? 5.086   -18.634 -53.174 1.00 20.22  ? 105 ASP H O    1 
ATOM   1819 C  CB   . ASP B 2 90  ? 2.752   -17.263 -53.535 1.00 18.06  ? 105 ASP H CB   1 
ATOM   1820 C  CG   . ASP B 2 90  ? 3.489   -16.215 -54.337 1.00 17.34  ? 105 ASP H CG   1 
ATOM   1821 O  OD1  . ASP B 2 90  ? 3.889   -16.519 -55.462 1.00 17.00  ? 105 ASP H OD1  1 
ATOM   1822 O  OD2  . ASP B 2 90  ? 3.649   -15.108 -53.821 1.00 18.09  ? 105 ASP H OD2  1 
ATOM   1823 N  N    . ILE B 2 91  ? 4.693   -20.103 -54.839 1.00 19.79  ? 106 ILE H N    1 
ATOM   1824 C  CA   . ILE B 2 91  ? 5.956   -20.797 -54.767 1.00 19.27  ? 106 ILE H CA   1 
ATOM   1825 C  C    . ILE B 2 91  ? 6.322   -21.274 -56.169 1.00 19.57  ? 106 ILE H C    1 
ATOM   1826 O  O    . ILE B 2 91  ? 5.471   -21.674 -56.946 1.00 17.62  ? 106 ILE H O    1 
ATOM   1827 C  CB   . ILE B 2 91  ? 5.878   -21.950 -53.751 1.00 18.70  ? 106 ILE H CB   1 
ATOM   1828 C  CG1  . ILE B 2 91  ? 7.200   -22.697 -53.631 1.00 18.03  ? 106 ILE H CG1  1 
ATOM   1829 C  CG2  . ILE B 2 91  ? 4.751   -22.910 -54.079 1.00 20.43  ? 106 ILE H CG2  1 
ATOM   1830 C  CD1  . ILE B 2 91  ? 7.369   -23.363 -52.288 1.00 19.83  ? 106 ILE H CD1  1 
ATOM   1831 N  N    . ALA B 2 92  ? 7.624   -21.242 -56.456 1.00 21.84  ? 107 ALA H N    1 
ATOM   1832 C  CA   . ALA B 2 92  ? 8.174   -21.650 -57.734 1.00 21.18  ? 107 ALA H CA   1 
ATOM   1833 C  C    . ALA B 2 92  ? 9.468   -22.422 -57.509 1.00 20.69  ? 107 ALA H C    1 
ATOM   1834 O  O    . ALA B 2 92  ? 10.276  -22.064 -56.639 1.00 17.28  ? 107 ALA H O    1 
ATOM   1835 C  CB   . ALA B 2 92  ? 8.428   -20.425 -58.569 1.00 21.81  ? 107 ALA H CB   1 
ATOM   1836 N  N    . LEU B 2 93  ? 9.648   -23.469 -58.328 1.00 21.39  ? 108 LEU H N    1 
ATOM   1837 C  CA   . LEU B 2 93  ? 10.874  -24.242 -58.306 1.00 20.91  ? 108 LEU H CA   1 
ATOM   1838 C  C    . LEU B 2 93  ? 11.550  -24.094 -59.658 1.00 20.98  ? 108 LEU H C    1 
ATOM   1839 O  O    . LEU B 2 93  ? 10.891  -24.212 -60.684 1.00 22.94  ? 108 LEU H O    1 
ATOM   1840 C  CB   . LEU B 2 93  ? 10.573  -25.697 -57.942 1.00 20.18  ? 108 LEU H CB   1 
ATOM   1841 C  CG   . LEU B 2 93  ? 11.797  -26.609 -57.819 1.00 20.47  ? 108 LEU H CG   1 
ATOM   1842 C  CD1  . LEU B 2 93  ? 12.712  -26.170 -56.682 1.00 19.41  ? 108 LEU H CD1  1 
ATOM   1843 C  CD2  . LEU B 2 93  ? 11.367  -28.055 -57.619 1.00 20.91  ? 108 LEU H CD2  1 
ATOM   1844 N  N    . LEU B 2 94  ? 12.846  -23.753 -59.627 1.00 21.91  ? 109 LEU H N    1 
ATOM   1845 C  CA   . LEU B 2 94  ? 13.599  -23.333 -60.807 1.00 22.99  ? 109 LEU H CA   1 
ATOM   1846 C  C    . LEU B 2 94  ? 14.793  -24.259 -61.006 1.00 21.51  ? 109 LEU H C    1 
ATOM   1847 O  O    . LEU B 2 94  ? 15.593  -24.405 -60.086 1.00 18.29  ? 109 LEU H O    1 
ATOM   1848 C  CB   . LEU B 2 94  ? 14.098  -21.902 -60.612 1.00 24.80  ? 109 LEU H CB   1 
ATOM   1849 C  CG   . LEU B 2 94  ? 13.165  -20.783 -61.055 1.00 29.13  ? 109 LEU H CG   1 
ATOM   1850 C  CD1  . LEU B 2 94  ? 11.963  -20.638 -60.132 1.00 30.96  ? 109 LEU H CD1  1 
ATOM   1851 C  CD2  . LEU B 2 94  ? 13.935  -19.474 -61.122 1.00 29.60  ? 109 LEU H CD2  1 
ATOM   1852 N  N    . ARG B 2 95  ? 14.897  -24.887 -62.191 1.00 23.41  ? 110 ARG H N    1 
ATOM   1853 C  CA   . ARG B 2 95  ? 16.068  -25.686 -62.514 1.00 25.23  ? 110 ARG H CA   1 
ATOM   1854 C  C    . ARG B 2 95  ? 17.051  -24.842 -63.324 1.00 25.33  ? 110 ARG H C    1 
ATOM   1855 O  O    . ARG B 2 95  ? 16.665  -24.175 -64.286 1.00 25.45  ? 110 ARG H O    1 
ATOM   1856 C  CB   . ARG B 2 95  ? 15.659  -26.929 -63.284 1.00 28.77  ? 110 ARG H CB   1 
ATOM   1857 C  CG   . ARG B 2 95  ? 16.744  -27.995 -63.314 1.00 34.96  ? 110 ARG H CG   1 
ATOM   1858 C  CD   . ARG B 2 95  ? 16.547  -29.000 -64.441 1.00 41.83  ? 110 ARG H CD   1 
ATOM   1859 N  NE   . ARG B 2 95  ? 15.150  -29.389 -64.562 1.00 46.07  ? 110 ARG H NE   1 
ATOM   1860 C  CZ   . ARG B 2 95  ? 14.633  -30.539 -64.137 1.00 53.53  ? 110 ARG H CZ   1 
ATOM   1861 N  NH1  . ARG B 2 95  ? 15.420  -31.490 -63.655 1.00 49.84  ? 110 ARG H NH1  1 
ATOM   1862 N  NH2  . ARG B 2 95  ? 13.323  -30.737 -64.231 1.00 52.38  ? 110 ARG H NH2  1 
ATOM   1863 N  N    . LEU B 2 96  ? 18.306  -24.806 -62.879 1.00 23.78  ? 111 LEU H N    1 
ATOM   1864 C  CA   . LEU B 2 96  ? 19.357  -24.110 -63.611 1.00 26.04  ? 111 LEU H CA   1 
ATOM   1865 C  C    . LEU B 2 96  ? 19.875  -25.013 -64.729 1.00 27.02  ? 111 LEU H C    1 
ATOM   1866 O  O    . LEU B 2 96  ? 19.831  -26.242 -64.616 1.00 28.37  ? 111 LEU H O    1 
ATOM   1867 C  CB   . LEU B 2 96  ? 20.494  -23.743 -62.649 1.00 26.10  ? 111 LEU H CB   1 
ATOM   1868 C  CG   . LEU B 2 96  ? 20.124  -22.820 -61.483 1.00 26.26  ? 111 LEU H CG   1 
ATOM   1869 C  CD1  . LEU B 2 96  ? 21.348  -22.452 -60.654 1.00 24.92  ? 111 LEU H CD1  1 
ATOM   1870 C  CD2  . LEU B 2 96  ? 19.413  -21.562 -61.968 1.00 26.16  ? 111 LEU H CD2  1 
ATOM   1871 N  N    . HIS B 2 97  ? 20.381  -24.381 -65.790 1.00 27.93  ? 112 HIS H N    1 
ATOM   1872 C  CA   . HIS B 2 97  ? 20.781  -25.084 -67.000 1.00 33.58  ? 112 HIS H CA   1 
ATOM   1873 C  C    . HIS B 2 97  ? 22.047  -25.899 -66.703 1.00 29.84  ? 112 HIS H C    1 
ATOM   1874 O  O    . HIS B 2 97  ? 22.105  -27.095 -66.975 1.00 27.91  ? 112 HIS H O    1 
ATOM   1875 C  CB   . HIS B 2 97  ? 20.773  -24.107 -68.191 1.00 39.82  ? 112 HIS H CB   1 
ATOM   1876 C  CG   . HIS B 2 97  ? 21.440  -24.632 -69.413 1.00 53.97  ? 112 HIS H CG   1 
ATOM   1877 N  ND1  . HIS B 2 97  ? 22.559  -24.020 -69.943 1.00 68.30  ? 112 HIS H ND1  1 
ATOM   1878 C  CD2  . HIS B 2 97  ? 21.199  -25.707 -70.177 1.00 60.68  ? 112 HIS H CD2  1 
ATOM   1879 C  CE1  . HIS B 2 97  ? 22.973  -24.704 -71.000 1.00 70.34  ? 112 HIS H CE1  1 
ATOM   1880 N  NE2  . HIS B 2 97  ? 22.161  -25.738 -71.159 1.00 67.12  ? 112 HIS H NE2  1 
ATOM   1881 N  N    . GLN B 2 98  ? 23.032  -25.253 -66.076 1.00 28.65  ? 113 GLN H N    1 
ATOM   1882 C  CA   . GLN B 2 98  ? 24.228  -25.898 -65.558 1.00 28.06  ? 113 GLN H CA   1 
ATOM   1883 C  C    . GLN B 2 98  ? 24.321  -25.620 -64.062 1.00 24.52  ? 113 GLN H C    1 
ATOM   1884 O  O    . GLN B 2 98  ? 23.785  -24.633 -63.590 1.00 21.39  ? 113 GLN H O    1 
ATOM   1885 C  CB   . GLN B 2 98  ? 25.480  -25.312 -66.221 1.00 31.70  ? 113 GLN H CB   1 
ATOM   1886 C  CG   . GLN B 2 98  ? 25.621  -25.606 -67.709 1.00 31.94  ? 113 GLN H CG   1 
ATOM   1887 C  CD   . GLN B 2 98  ? 25.773  -27.089 -67.963 1.00 35.74  ? 113 GLN H CD   1 
ATOM   1888 O  OE1  . GLN B 2 98  ? 26.396  -27.829 -67.197 1.00 40.37  ? 113 GLN H OE1  1 
ATOM   1889 N  NE2  . GLN B 2 98  ? 25.164  -27.555 -69.034 1.00 40.77  ? 113 GLN H NE2  1 
ATOM   1890 N  N    . PRO B 2 99  ? 25.007  -26.462 -63.276 1.00 24.30  ? 114 PRO H N    1 
ATOM   1891 C  CA   . PRO B 2 99  ? 25.175  -26.238 -61.846 1.00 26.98  ? 114 PRO H CA   1 
ATOM   1892 C  C    . PRO B 2 99  ? 25.898  -24.941 -61.551 1.00 29.41  ? 114 PRO H C    1 
ATOM   1893 O  O    . PRO B 2 99  ? 26.654  -24.482 -62.395 1.00 33.76  ? 114 PRO H O    1 
ATOM   1894 C  CB   . PRO B 2 99  ? 26.092  -27.371 -61.353 1.00 25.06  ? 114 PRO H CB   1 
ATOM   1895 C  CG   . PRO B 2 99  ? 25.958  -28.443 -62.412 1.00 26.07  ? 114 PRO H CG   1 
ATOM   1896 C  CD   . PRO B 2 99  ? 25.610  -27.725 -63.708 1.00 26.81  ? 114 PRO H CD   1 
ATOM   1897 N  N    . VAL B 2 100 ? 25.700  -24.406 -60.339 1.00 28.38  ? 115 VAL H N    1 
ATOM   1898 C  CA   . VAL B 2 100 ? 26.606  -23.408 -59.797 1.00 27.44  ? 115 VAL H CA   1 
ATOM   1899 C  C    . VAL B 2 100 ? 27.788  -24.134 -59.187 1.00 25.33  ? 115 VAL H C    1 
ATOM   1900 O  O    . VAL B 2 100 ? 27.703  -25.320 -58.890 1.00 26.23  ? 115 VAL H O    1 
ATOM   1901 C  CB   . VAL B 2 100 ? 25.939  -22.476 -58.766 1.00 29.72  ? 115 VAL H CB   1 
ATOM   1902 C  CG1  . VAL B 2 100 ? 24.869  -21.614 -59.404 1.00 31.84  ? 115 VAL H CG1  1 
ATOM   1903 C  CG2  . VAL B 2 100 ? 25.346  -23.225 -57.594 1.00 31.92  ? 115 VAL H CG2  1 
ATOM   1904 N  N    . VAL B 2 101 ? 28.881  -23.397 -59.016 1.00 24.92  ? 116 VAL H N    1 
ATOM   1905 C  CA   . VAL B 2 101 ? 30.045  -23.887 -58.300 1.00 25.24  ? 116 VAL H CA   1 
ATOM   1906 C  C    . VAL B 2 101 ? 29.943  -23.336 -56.885 1.00 23.75  ? 116 VAL H C    1 
ATOM   1907 O  O    . VAL B 2 101 ? 29.782  -22.132 -56.727 1.00 28.29  ? 116 VAL H O    1 
ATOM   1908 C  CB   . VAL B 2 101 ? 31.358  -23.456 -59.005 1.00 26.06  ? 116 VAL H CB   1 
ATOM   1909 C  CG1  . VAL B 2 101 ? 32.624  -23.672 -58.177 1.00 25.54  ? 116 VAL H CG1  1 
ATOM   1910 C  CG2  . VAL B 2 101 ? 31.509  -24.155 -60.323 1.00 26.16  ? 116 VAL H CG2  1 
ATOM   1911 N  N    . LEU B 2 102 ? 30.051  -24.209 -55.882 1.00 22.23  ? 117 LEU H N    1 
ATOM   1912 C  CA   . LEU B 2 102 ? 29.964  -23.801 -54.487 1.00 24.35  ? 117 LEU H CA   1 
ATOM   1913 C  C    . LEU B 2 102 ? 31.297  -23.177 -54.055 1.00 25.80  ? 117 LEU H C    1 
ATOM   1914 O  O    . LEU B 2 102 ? 32.343  -23.743 -54.327 1.00 29.83  ? 117 LEU H O    1 
ATOM   1915 C  CB   . LEU B 2 102 ? 29.580  -25.016 -53.623 1.00 24.77  ? 117 LEU H CB   1 
ATOM   1916 C  CG   . LEU B 2 102 ? 28.211  -25.661 -53.907 1.00 25.58  ? 117 LEU H CG   1 
ATOM   1917 C  CD1  . LEU B 2 102 ? 27.793  -26.612 -52.796 1.00 25.04  ? 117 LEU H CD1  1 
ATOM   1918 C  CD2  . LEU B 2 102 ? 27.128  -24.610 -54.083 1.00 26.17  ? 117 LEU H CD2  1 
ATOM   1919 N  N    . THR B 2 103 ? 31.233  -21.998 -53.419 1.00 24.01  ? 118 THR H N    1 
ATOM   1920 C  CA   . THR B 2 103 ? 32.384  -21.215 -52.995 1.00 25.44  ? 118 THR H CA   1 
ATOM   1921 C  C    . THR B 2 103 ? 32.097  -20.571 -51.634 1.00 27.79  ? 118 THR H C    1 
ATOM   1922 O  O    . THR B 2 103 ? 31.000  -20.698 -51.091 1.00 30.10  ? 118 THR H O    1 
ATOM   1923 C  CB   . THR B 2 103 ? 32.722  -20.114 -54.016 1.00 24.37  ? 118 THR H CB   1 
ATOM   1924 O  OG1  . THR B 2 103 ? 31.678  -19.132 -54.015 1.00 24.77  ? 118 THR H OG1  1 
ATOM   1925 C  CG2  . THR B 2 103 ? 32.897  -20.653 -55.415 1.00 23.53  ? 118 THR H CG2  1 
ATOM   1926 N  N    . ASP B 2 104 ? 33.079  -19.847 -51.085 1.00 28.81  ? 119 ASP H N    1 
ATOM   1927 C  CA   . ASP B 2 104 ? 32.882  -19.169 -49.815 1.00 32.09  ? 119 ASP H CA   1 
ATOM   1928 C  C    . ASP B 2 104 ? 31.713  -18.197 -49.941 1.00 30.06  ? 119 ASP H C    1 
ATOM   1929 O  O    . ASP B 2 104 ? 31.156  -17.758 -48.931 1.00 33.14  ? 119 ASP H O    1 
ATOM   1930 C  CB   . ASP B 2 104 ? 34.139  -18.438 -49.350 1.00 33.93  ? 119 ASP H CB   1 
ATOM   1931 C  CG   . ASP B 2 104 ? 35.275  -19.362 -48.952 1.00 38.97  ? 119 ASP H CG   1 
ATOM   1932 O  OD1  . ASP B 2 104 ? 35.032  -20.561 -48.764 1.00 39.77  ? 119 ASP H OD1  1 
ATOM   1933 O  OD2  . ASP B 2 104 ? 36.400  -18.871 -48.856 1.00 47.89  ? 119 ASP H OD2  1 
ATOM   1934 N  N    . HIS B 2 105 ? 31.343  -17.894 -51.184 1.00 26.14  ? 120 HIS H N    1 
ATOM   1935 C  CA   . HIS B 2 105 ? 30.379  -16.845 -51.460 1.00 25.42  ? 120 HIS H CA   1 
ATOM   1936 C  C    . HIS B 2 105 ? 29.060  -17.402 -51.977 1.00 24.08  ? 120 HIS H C    1 
ATOM   1937 O  O    . HIS B 2 105 ? 28.115  -16.629 -52.091 1.00 23.53  ? 120 HIS H O    1 
ATOM   1938 C  CB   . HIS B 2 105 ? 30.973  -15.835 -52.449 1.00 24.87  ? 120 HIS H CB   1 
ATOM   1939 C  CG   . HIS B 2 105 ? 31.910  -14.941 -51.750 1.00 24.74  ? 120 HIS H CG   1 
ATOM   1940 N  ND1  . HIS B 2 105 ? 33.264  -15.180 -51.673 1.00 27.06  ? 120 HIS H ND1  1 
ATOM   1941 C  CD2  . HIS B 2 105 ? 31.654  -13.883 -50.984 1.00 24.05  ? 120 HIS H CD2  1 
ATOM   1942 C  CE1  . HIS B 2 105 ? 33.807  -14.249 -50.908 1.00 27.76  ? 120 HIS H CE1  1 
ATOM   1943 N  NE2  . HIS B 2 105 ? 32.839  -13.444 -50.486 1.00 26.67  ? 120 HIS H NE2  1 
ATOM   1944 N  N    . VAL B 2 106 ? 29.020  -18.707 -52.296 1.00 22.41  ? 121 VAL H N    1 
ATOM   1945 C  CA   . VAL B 2 106 ? 27.863  -19.311 -52.933 1.00 20.63  ? 121 VAL H CA   1 
ATOM   1946 C  C    . VAL B 2 106 ? 27.572  -20.657 -52.295 1.00 19.30  ? 121 VAL H C    1 
ATOM   1947 O  O    . VAL B 2 106 ? 28.182  -21.648 -52.633 1.00 17.62  ? 121 VAL H O    1 
ATOM   1948 C  CB   . VAL B 2 106 ? 28.028  -19.459 -54.456 1.00 20.85  ? 121 VAL H CB   1 
ATOM   1949 C  CG1  . VAL B 2 106 ? 26.870  -20.232 -55.065 1.00 21.01  ? 121 VAL H CG1  1 
ATOM   1950 C  CG2  . VAL B 2 106 ? 28.146  -18.107 -55.134 1.00 21.25  ? 121 VAL H CG2  1 
ATOM   1951 N  N    . VAL B 2 107 ? 26.563  -20.682 -51.419 1.00 20.90  ? 122 VAL H N    1 
ATOM   1952 C  CA   . VAL B 2 107 ? 26.237  -21.869 -50.641 1.00 20.79  ? 122 VAL H CA   1 
ATOM   1953 C  C    . VAL B 2 107 ? 24.720  -22.027 -50.578 1.00 19.81  ? 122 VAL H C    1 
ATOM   1954 O  O    . VAL B 2 107 ? 23.999  -21.042 -50.410 1.00 19.47  ? 122 VAL H O    1 
ATOM   1955 C  CB   . VAL B 2 107 ? 26.827  -21.745 -49.228 1.00 21.74  ? 122 VAL H CB   1 
ATOM   1956 C  CG1  . VAL B 2 107 ? 26.323  -22.840 -48.328 1.00 24.07  ? 122 VAL H CG1  1 
ATOM   1957 C  CG2  . VAL B 2 107 ? 28.341  -21.741 -49.236 1.00 23.04  ? 122 VAL H CG2  1 
ATOM   1958 N  N    . PRO B 2 108 ? 24.187  -23.263 -50.634 1.00 18.50  ? 123 PRO H N    1 
ATOM   1959 C  CA   . PRO B 2 108 ? 22.744  -23.460 -50.505 1.00 18.61  ? 123 PRO H CA   1 
ATOM   1960 C  C    . PRO B 2 108 ? 22.239  -23.384 -49.063 1.00 18.90  ? 123 PRO H C    1 
ATOM   1961 O  O    . PRO B 2 108 ? 22.970  -23.680 -48.103 1.00 18.20  ? 123 PRO H O    1 
ATOM   1962 C  CB   . PRO B 2 108 ? 22.507  -24.864 -51.092 1.00 18.70  ? 123 PRO H CB   1 
ATOM   1963 C  CG   . PRO B 2 108 ? 23.850  -25.588 -50.967 1.00 18.88  ? 123 PRO H CG   1 
ATOM   1964 C  CD   . PRO B 2 108 ? 24.918  -24.518 -50.873 1.00 18.88  ? 123 PRO H CD   1 
ATOM   1965 N  N    . LEU B 2 109 ? 20.973  -22.965 -48.946 1.00 17.87  ? 124 LEU H N    1 
ATOM   1966 C  CA   . LEU B 2 109 ? 20.234  -23.034 -47.702 1.00 18.09  ? 124 LEU H CA   1 
ATOM   1967 C  C    . LEU B 2 109 ? 19.639  -24.432 -47.629 1.00 17.18  ? 124 LEU H C    1 
ATOM   1968 O  O    . LEU B 2 109 ? 19.396  -25.018 -48.675 1.00 18.01  ? 124 LEU H O    1 
ATOM   1969 C  CB   . LEU B 2 109 ? 19.162  -21.947 -47.713 1.00 18.37  ? 124 LEU H CB   1 
ATOM   1970 C  CG   . LEU B 2 109 ? 18.482  -21.663 -46.379 1.00 18.76  ? 124 LEU H CG   1 
ATOM   1971 C  CD1  . LEU B 2 109 ? 19.469  -21.160 -45.333 1.00 19.03  ? 124 LEU H CD1  1 
ATOM   1972 C  CD2  . LEU B 2 109 ? 17.369  -20.661 -46.571 1.00 17.87  ? 124 LEU H CD2  1 
ATOM   1973 N  N    . CYS B 2 110 ? 19.538  -25.010 -46.427 1.00 15.87  ? 125 CYS H N    1 
ATOM   1974 C  CA   . CYS B 2 110 ? 19.026  -26.359 -46.326 1.00 16.69  ? 125 CYS H CA   1 
ATOM   1975 C  C    . CYS B 2 110 ? 17.503  -26.300 -46.409 1.00 18.08  ? 125 CYS H C    1 
ATOM   1976 O  O    . CYS B 2 110 ? 16.878  -25.527 -45.672 1.00 17.62  ? 125 CYS H O    1 
ATOM   1977 C  CB   . CYS B 2 110 ? 19.350  -27.031 -44.994 1.00 18.04  ? 125 CYS H CB   1 
ATOM   1978 S  SG   . CYS B 2 110 ? 21.094  -27.140 -44.529 1.00 16.25  ? 125 CYS H SG   1 
ATOM   1979 N  N    . LEU B 2 111 ? 16.925  -27.124 -47.294 1.00 19.87  ? 126 LEU H N    1 
ATOM   1980 C  CA   . LEU B 2 111 ? 15.507  -27.459 -47.275 1.00 20.23  ? 126 LEU H CA   1 
ATOM   1981 C  C    . LEU B 2 111 ? 15.319  -28.471 -46.168 1.00 19.70  ? 126 LEU H C    1 
ATOM   1982 O  O    . LEU B 2 111 ? 16.059  -29.423 -46.104 1.00 22.23  ? 126 LEU H O    1 
ATOM   1983 C  CB   . LEU B 2 111 ? 15.096  -28.044 -48.629 1.00 21.14  ? 126 LEU H CB   1 
ATOM   1984 C  CG   . LEU B 2 111 ? 13.598  -28.273 -48.833 1.00 22.04  ? 126 LEU H CG   1 
ATOM   1985 C  CD1  . LEU B 2 111 ? 12.852  -26.936 -48.912 1.00 23.09  ? 126 LEU H CD1  1 
ATOM   1986 C  CD2  . LEU B 2 111 ? 13.317  -29.110 -50.092 1.00 21.10  ? 126 LEU H CD2  1 
ATOM   1987 N  N    . PRO B 2 112 ? 14.445  -28.242 -45.175 1.00 20.91  ? 127 PRO H N    1 
ATOM   1988 C  CA   . PRO B 2 112 ? 14.274  -29.209 -44.085 1.00 20.53  ? 127 PRO H CA   1 
ATOM   1989 C  C    . PRO B 2 112 ? 13.190  -30.253 -44.322 1.00 22.32  ? 127 PRO H C    1 
ATOM   1990 O  O    . PRO B 2 112 ? 12.379  -30.103 -45.227 1.00 24.29  ? 127 PRO H O    1 
ATOM   1991 C  CB   . PRO B 2 112 ? 13.861  -28.273 -42.947 1.00 20.75  ? 127 PRO H CB   1 
ATOM   1992 C  CG   . PRO B 2 112 ? 13.010  -27.249 -43.641 1.00 20.95  ? 127 PRO H CG   1 
ATOM   1993 C  CD   . PRO B 2 112 ? 13.652  -27.017 -44.998 1.00 19.60  ? 127 PRO H CD   1 
ATOM   1994 N  N    . GLU B 2 113 ? 13.164  -31.303 -43.497 1.00 25.32  ? 128 GLU H N    1 
ATOM   1995 C  CA   . GLU B 2 113 ? 12.028  -32.211 -43.468 1.00 29.49  ? 128 GLU H CA   1 
ATOM   1996 C  C    . GLU B 2 113 ? 10.786  -31.506 -42.942 1.00 28.30  ? 128 GLU H C    1 
ATOM   1997 O  O    . GLU B 2 113 ? 10.907  -30.601 -42.127 1.00 28.82  ? 128 GLU H O    1 
ATOM   1998 C  CB   . GLU B 2 113 ? 12.228  -33.350 -42.475 1.00 32.92  ? 128 GLU H CB   1 
ATOM   1999 C  CG   . GLU B 2 113 ? 13.155  -34.433 -42.940 1.00 35.37  ? 128 GLU H CG   1 
ATOM   2000 C  CD   . GLU B 2 113 ? 13.308  -35.484 -41.863 1.00 40.98  ? 128 GLU H CD   1 
ATOM   2001 O  OE1  . GLU B 2 113 ? 12.785  -35.257 -40.714 1.00 39.82  ? 128 GLU H OE1  1 
ATOM   2002 O  OE2  . GLU B 2 113 ? 13.931  -36.524 -42.174 1.00 42.38  ? 128 GLU H OE2  1 
ATOM   2003 N  N    . ARG B 2 114 ? 9.611   -32.035 -43.312 1.00 29.99  ? 129 ARG H N    1 
ATOM   2004 C  CA   . ARG B 2 114 ? 8.332   -31.401 -43.024 1.00 29.72  ? 129 ARG H CA   1 
ATOM   2005 C  C    . ARG B 2 114 ? 8.111   -31.369 -41.517 1.00 30.13  ? 129 ARG H C    1 
ATOM   2006 O  O    . ARG B 2 114 ? 7.742   -30.318 -41.004 1.00 31.44  ? 129 ARG H O    1 
ATOM   2007 C  CB   . ARG B 2 114 ? 7.181   -32.119 -43.732 1.00 29.58  ? 129 ARG H CB   1 
ATOM   2008 C  CG   . ARG B 2 114 ? 5.842   -31.394 -43.691 1.00 31.84  ? 129 ARG H CG   1 
ATOM   2009 C  CD   . ARG B 2 114 ? 4.707   -32.320 -44.099 1.00 34.55  ? 129 ARG H CD   1 
ATOM   2010 N  NE   . ARG B 2 114 ? 3.573   -31.637 -44.716 1.00 43.61  ? 129 ARG H NE   1 
ATOM   2011 C  CZ   . ARG B 2 114 ? 3.415   -31.424 -46.035 1.00 52.71  ? 129 ARG H CZ   1 
ATOM   2012 N  NH1  . ARG B 2 114 ? 4.408   -31.635 -46.902 1.00 50.65  ? 129 ARG H NH1  1 
ATOM   2013 N  NH2  . ARG B 2 114 ? 2.268   -30.923 -46.475 1.00 53.37  ? 129 ARG H NH2  1 
ATOM   2014 N  N    . THR B 2 115 ? 8.368   -32.486 -40.814 1.00 26.31  ? 130 THR H N    1 
ATOM   2015 C  CA   . THR B 2 115 ? 8.038   -32.567 -39.399 1.00 26.18  ? 130 THR H CA   1 
ATOM   2016 C  C    . THR B 2 115 ? 9.017   -31.704 -38.598 1.00 24.26  ? 130 THR H C    1 
ATOM   2017 O  O    . THR B 2 115 ? 8.622   -31.039 -37.662 1.00 24.92  ? 130 THR H O    1 
ATOM   2018 C  CB   . THR B 2 115 ? 7.937   -34.023 -38.896 1.00 29.65  ? 130 THR H CB   1 
ATOM   2019 O  OG1  . THR B 2 115 ? 9.192   -34.704 -38.940 1.00 38.83  ? 130 THR H OG1  1 
ATOM   2020 C  CG2  . THR B 2 115 ? 6.956   -34.861 -39.678 1.00 26.65  ? 130 THR H CG2  1 
ATOM   2021 N  N    . PHE B 2 116 ? 10.298  -31.673 -38.973 1.00 22.64  ? 131 PHE H N    1 
ATOM   2022 C  CA   . PHE B 2 116 ? 11.267  -30.886 -38.237 1.00 21.16  ? 131 PHE H CA   1 
ATOM   2023 C  C    . PHE B 2 116 ? 10.824  -29.433 -38.299 1.00 19.59  ? 131 PHE H C    1 
ATOM   2024 O  O    . PHE B 2 116 ? 10.777  -28.749 -37.289 1.00 21.96  ? 131 PHE H O    1 
ATOM   2025 C  CB   . PHE B 2 116 ? 12.677  -31.141 -38.782 1.00 22.02  ? 131 PHE H CB   1 
ATOM   2026 C  CG   . PHE B 2 116 ? 13.748  -30.175 -38.331 1.00 21.36  ? 131 PHE H CG   1 
ATOM   2027 C  CD1  . PHE B 2 116 ? 14.113  -30.074 -36.999 1.00 19.70  ? 131 PHE H CD1  1 
ATOM   2028 C  CD2  . PHE B 2 116 ? 14.392  -29.342 -39.244 1.00 20.87  ? 131 PHE H CD2  1 
ATOM   2029 C  CE1  . PHE B 2 116 ? 15.080  -29.163 -36.595 1.00 18.09  ? 131 PHE H CE1  1 
ATOM   2030 C  CE2  . PHE B 2 116 ? 15.354  -28.429 -38.834 1.00 17.80  ? 131 PHE H CE2  1 
ATOM   2031 C  CZ   . PHE B 2 116 ? 15.688  -28.337 -37.509 1.00 17.66  ? 131 PHE H CZ   1 
ATOM   2032 N  N    . SER B 2 117 ? 10.375  -29.028 -39.474 1.00 18.73  ? 132 SER H N    1 
ATOM   2033 C  CA   . SER B 2 117 ? 10.003  -27.654 -39.736 1.00 19.45  ? 132 SER H CA   1 
ATOM   2034 C  C    . SER B 2 117 ? 8.758   -27.233 -38.966 1.00 20.13  ? 132 SER H C    1 
ATOM   2035 O  O    . SER B 2 117 ? 8.739   -26.131 -38.408 1.00 20.69  ? 132 SER H O    1 
ATOM   2036 C  CB   . SER B 2 117 ? 9.793   -27.423 -41.171 1.00 19.24  ? 132 SER H CB   1 
ATOM   2037 O  OG   . SER B 2 117 ? 9.753   -26.036 -41.342 1.00 21.73  ? 132 SER H OG   1 
ATOM   2038 N  N    . GLU B 2 118 ? 7.752   -28.116 -38.949 1.00 19.23  ? 133 GLU H N    1 
ATOM   2039 C  CA   . GLU B 2 118 ? 6.486   -27.851 -38.291 1.00 21.23  ? 133 GLU H CA   1 
ATOM   2040 C  C    . GLU B 2 118 ? 6.583   -27.928 -36.770 1.00 19.94  ? 133 GLU H C    1 
ATOM   2041 O  O    . GLU B 2 118 ? 5.883   -27.202 -36.073 1.00 20.04  ? 133 GLU H O    1 
ATOM   2042 C  CB   . GLU B 2 118 ? 5.432   -28.843 -38.766 1.00 23.79  ? 133 GLU H CB   1 
ATOM   2043 C  CG   . GLU B 2 118 ? 4.980   -28.535 -40.171 1.00 29.06  ? 133 GLU H CG   1 
ATOM   2044 C  CD   . GLU B 2 118 ? 3.934   -29.467 -40.737 1.00 30.79  ? 133 GLU H CD   1 
ATOM   2045 O  OE1  . GLU B 2 118 ? 3.654   -30.486 -40.077 1.00 31.00  ? 133 GLU H OE1  1 
ATOM   2046 O  OE2  . GLU B 2 118 ? 3.423   -29.150 -41.834 1.00 33.58  ? 133 GLU H OE2  1 
ATOM   2047 N  N    . ARG B 2 119 ? 7.411   -28.836 -36.279 1.00 20.10  ? 134 ARG H N    1 
ATOM   2048 C  CA   . ARG B 2 119 ? 7.486   -29.175 -34.865 1.00 22.74  ? 134 ARG H CA   1 
ATOM   2049 C  C    . ARG B 2 119 ? 8.584   -28.355 -34.175 1.00 19.99  ? 134 ARG H C    1 
ATOM   2050 O  O    . ARG B 2 119 ? 8.480   -28.106 -32.985 1.00 17.75  ? 134 ARG H O    1 
ATOM   2051 C  CB   . ARG B 2 119 ? 7.689   -30.698 -34.782 1.00 28.01  ? 134 ARG H CB   1 
ATOM   2052 C  CG   . ARG B 2 119 ? 8.284   -31.236 -33.492 1.00 36.99  ? 134 ARG H CG   1 
ATOM   2053 C  CD   . ARG B 2 119 ? 8.835   -32.634 -33.709 1.00 42.54  ? 134 ARG H CD   1 
ATOM   2054 N  NE   . ARG B 2 119 ? 7.763   -33.577 -34.008 1.00 51.95  ? 134 ARG H NE   1 
ATOM   2055 C  CZ   . ARG B 2 119 ? 7.929   -34.865 -34.320 1.00 55.51  ? 134 ARG H CZ   1 
ATOM   2056 N  NH1  . ARG B 2 119 ? 9.132   -35.332 -34.627 1.00 54.26  ? 134 ARG H NH1  1 
ATOM   2057 N  NH2  . ARG B 2 119 ? 6.874   -35.671 -34.353 1.00 50.37  ? 134 ARG H NH2  1 
ATOM   2058 N  N    . THR B 2 120 ? 9.632   -27.936 -34.913 1.00 18.33  ? 135 THR H N    1 
ATOM   2059 C  CA   . THR B 2 120 ? 10.769  -27.250 -34.319 1.00 16.75  ? 135 THR H CA   1 
ATOM   2060 C  C    . THR B 2 120 ? 11.008  -25.882 -34.983 1.00 17.13  ? 135 THR H C    1 
ATOM   2061 O  O    . THR B 2 120 ? 10.990  -24.837 -34.334 1.00 15.40  ? 135 THR H O    1 
ATOM   2062 C  CB   . THR B 2 120 ? 11.997  -28.158 -34.397 1.00 16.64  ? 135 THR H CB   1 
ATOM   2063 O  OG1  . THR B 2 120 ? 11.744  -29.337 -33.653 1.00 16.35  ? 135 THR H OG1  1 
ATOM   2064 C  CG2  . THR B 2 120 ? 13.255  -27.545 -33.829 1.00 18.12  ? 135 THR H CG2  1 
ATOM   2065 N  N    . LEU B 2 121 ? 11.283  -25.844 -36.288 1.00 17.60  ? 136 LEU H N    1 
ATOM   2066 C  CA   . LEU B 2 121 ? 11.610  -24.557 -36.887 1.00 18.14  ? 136 LEU H CA   1 
ATOM   2067 C  C    . LEU B 2 121 ? 10.506  -23.529 -36.681 1.00 17.74  ? 136 LEU H C    1 
ATOM   2068 O  O    . LEU B 2 121 ? 10.822  -22.362 -36.494 1.00 17.84  ? 136 LEU H O    1 
ATOM   2069 C  CB   . LEU B 2 121 ? 11.904  -24.734 -38.364 1.00 17.83  ? 136 LEU H CB   1 
ATOM   2070 C  CG   . LEU B 2 121 ? 13.123  -25.594 -38.658 1.00 17.33  ? 136 LEU H CG   1 
ATOM   2071 C  CD1  . LEU B 2 121 ? 13.441  -25.546 -40.132 1.00 17.67  ? 136 LEU H CD1  1 
ATOM   2072 C  CD2  . LEU B 2 121 ? 14.303  -25.111 -37.850 1.00 18.44  ? 136 LEU H CD2  1 
ATOM   2073 N  N    . ALA B 2 122 ? 9.242   -23.976 -36.605 1.00 17.76  ? 137 ALA H N    1 
ATOM   2074 C  CA   . ALA B 2 122 ? 8.113   -23.058 -36.560 1.00 16.77  ? 137 ALA H CA   1 
ATOM   2075 C  C    . ALA B 2 122 ? 8.112   -22.250 -35.264 1.00 16.62  ? 137 ALA H C    1 
ATOM   2076 O  O    . ALA B 2 122 ? 7.500   -21.183 -35.228 1.00 17.48  ? 137 ALA H O    1 
ATOM   2077 C  CB   . ALA B 2 122 ? 6.817   -23.803 -36.772 1.00 15.77  ? 137 ALA H CB   1 
ATOM   2078 N  N    . PHE B 2 123 ? 8.840   -22.712 -34.237 1.00 16.65  ? 138 PHE H N    1 
ATOM   2079 C  CA   . PHE B 2 123 ? 8.757   -22.123 -32.906 1.00 17.76  ? 138 PHE H CA   1 
ATOM   2080 C  C    . PHE B 2 123 ? 10.041  -21.386 -32.529 1.00 18.10  ? 138 PHE H C    1 
ATOM   2081 O  O    . PHE B 2 123 ? 10.220  -21.024 -31.367 1.00 20.20  ? 138 PHE H O    1 
ATOM   2082 C  CB   . PHE B 2 123 ? 8.374   -23.197 -31.883 1.00 18.09  ? 138 PHE H CB   1 
ATOM   2083 C  CG   . PHE B 2 123 ? 7.001   -23.724 -32.159 1.00 20.95  ? 138 PHE H CG   1 
ATOM   2084 C  CD1  . PHE B 2 123 ? 5.934   -22.840 -32.250 1.00 21.73  ? 138 PHE H CD1  1 
ATOM   2085 C  CD2  . PHE B 2 123 ? 6.788   -25.070 -32.432 1.00 21.41  ? 138 PHE H CD2  1 
ATOM   2086 C  CE1  . PHE B 2 123 ? 4.663   -23.313 -32.559 1.00 24.33  ? 138 PHE H CE1  1 
ATOM   2087 C  CE2  . PHE B 2 123 ? 5.521   -25.538 -32.742 1.00 22.45  ? 138 PHE H CE2  1 
ATOM   2088 C  CZ   . PHE B 2 123 ? 4.456   -24.660 -32.798 1.00 23.63  ? 138 PHE H CZ   1 
ATOM   2089 N  N    . VAL B 2 124 ? 10.911  -21.168 -33.516 1.00 17.42  ? 139 VAL H N    1 
ATOM   2090 C  CA   . VAL B 2 124 ? 12.012  -20.237 -33.402 1.00 18.18  ? 139 VAL H CA   1 
ATOM   2091 C  C    . VAL B 2 124 ? 11.462  -18.866 -33.766 1.00 17.72  ? 139 VAL H C    1 
ATOM   2092 O  O    . VAL B 2 124 ? 10.879  -18.714 -34.812 1.00 19.42  ? 139 VAL H O    1 
ATOM   2093 C  CB   . VAL B 2 124 ? 13.173  -20.655 -34.331 1.00 17.31  ? 139 VAL H CB   1 
ATOM   2094 C  CG1  . VAL B 2 124 ? 14.305  -19.651 -34.302 1.00 16.16  ? 139 VAL H CG1  1 
ATOM   2095 C  CG2  . VAL B 2 124 ? 13.689  -22.034 -33.980 1.00 17.19  ? 139 VAL H CG2  1 
ATOM   2096 N  N    . ARG B 2 125 ? 11.621  -17.873 -32.904 1.00 18.75  ? 140 ARG H N    1 
ATOM   2097 C  CA   . ARG B 2 125 ? 10.848  -16.653 -33.055 1.00 18.58  ? 140 ARG H CA   1 
ATOM   2098 C  C    . ARG B 2 125 ? 11.291  -15.809 -34.259 1.00 17.31  ? 140 ARG H C    1 
ATOM   2099 O  O    . ARG B 2 125 ? 10.432  -15.309 -34.994 1.00 15.09  ? 140 ARG H O    1 
ATOM   2100 C  CB   . ARG B 2 125 ? 10.944  -15.794 -31.795 1.00 20.31  ? 140 ARG H CB   1 
ATOM   2101 C  CG   . ARG B 2 125 ? 9.995   -14.605 -31.879 1.00 23.21  ? 140 ARG H CG   1 
ATOM   2102 C  CD   . ARG B 2 125 ? 9.752   -13.929 -30.569 1.00 25.72  ? 140 ARG H CD   1 
ATOM   2103 N  NE   . ARG B 2 125 ? 9.223   -14.852 -29.566 1.00 26.91  ? 140 ARG H NE   1 
ATOM   2104 C  CZ   . ARG B 2 125 ? 7.995   -14.821 -29.090 1.00 26.09  ? 140 ARG H CZ   1 
ATOM   2105 N  NH1  . ARG B 2 125 ? 7.032   -14.209 -29.758 1.00 28.33  ? 140 ARG H NH1  1 
ATOM   2106 N  NH2  . ARG B 2 125 ? 7.742   -15.418 -27.948 1.00 26.51  ? 140 ARG H NH2  1 
ATOM   2107 N  N    . PHE B 2 126 ? 12.613  -15.593 -34.374 1.00 14.87  ? 141 PHE H N    1 
ATOM   2108 C  CA   . PHE B 2 126 ? 13.223  -14.686 -35.328 1.00 14.83  ? 141 PHE H CA   1 
ATOM   2109 C  C    . PHE B 2 126 ? 13.864  -15.478 -36.459 1.00 14.19  ? 141 PHE H C    1 
ATOM   2110 O  O    . PHE B 2 126 ? 14.565  -16.469 -36.239 1.00 13.99  ? 141 PHE H O    1 
ATOM   2111 C  CB   . PHE B 2 126 ? 14.263  -13.766 -34.663 1.00 15.13  ? 141 PHE H CB   1 
ATOM   2112 C  CG   . PHE B 2 126 ? 13.672  -12.632 -33.855 1.00 17.25  ? 141 PHE H CG   1 
ATOM   2113 C  CD1  . PHE B 2 126 ? 13.108  -11.531 -34.490 1.00 18.47  ? 141 PHE H CD1  1 
ATOM   2114 C  CD2  . PHE B 2 126 ? 13.680  -12.643 -32.467 1.00 18.14  ? 141 PHE H CD2  1 
ATOM   2115 C  CE1  . PHE B 2 126 ? 12.518  -10.502 -33.776 1.00 18.40  ? 141 PHE H CE1  1 
ATOM   2116 C  CE2  . PHE B 2 126 ? 13.080  -11.617 -31.754 1.00 19.30  ? 141 PHE H CE2  1 
ATOM   2117 C  CZ   . PHE B 2 126 ? 12.501  -10.549 -32.408 1.00 19.16  ? 141 PHE H CZ   1 
ATOM   2118 N  N    . SER B 2 127 ? 13.630  -14.984 -37.677 1.00 14.13  ? 142 SER H N    1 
ATOM   2119 C  CA   . SER B 2 127 ? 14.228  -15.518 -38.886 1.00 15.05  ? 142 SER H CA   1 
ATOM   2120 C  C    . SER B 2 127 ? 14.666  -14.327 -39.739 1.00 16.04  ? 142 SER H C    1 
ATOM   2121 O  O    . SER B 2 127 ? 14.223  -13.216 -39.495 1.00 16.85  ? 142 SER H O    1 
ATOM   2122 C  CB   . SER B 2 127 ? 13.227  -16.443 -39.589 1.00 15.95  ? 142 SER H CB   1 
ATOM   2123 O  OG   . SER B 2 127 ? 13.074  -17.682 -38.876 1.00 15.60  ? 142 SER H OG   1 
ATOM   2124 N  N    . LEU B 2 128 ? 15.558  -14.536 -40.708 1.00 17.14  ? 143 LEU H N    1 
ATOM   2125 C  CA   . LEU B 2 128 ? 16.061  -13.444 -41.526 1.00 17.30  ? 143 LEU H CA   1 
ATOM   2126 C  C    . LEU B 2 128 ? 15.362  -13.440 -42.872 1.00 17.55  ? 143 LEU H C    1 
ATOM   2127 O  O    . LEU B 2 128 ? 15.170  -14.487 -43.469 1.00 17.78  ? 143 LEU H O    1 
ATOM   2128 C  CB   . LEU B 2 128 ? 17.549  -13.636 -41.793 1.00 17.96  ? 143 LEU H CB   1 
ATOM   2129 C  CG   . LEU B 2 128 ? 18.468  -13.606 -40.586 1.00 19.17  ? 143 LEU H CG   1 
ATOM   2130 C  CD1  . LEU B 2 128 ? 19.907  -13.512 -41.069 1.00 20.12  ? 143 LEU H CD1  1 
ATOM   2131 C  CD2  . LEU B 2 128 ? 18.138  -12.451 -39.663 1.00 18.98  ? 143 LEU H CD2  1 
ATOM   2132 N  N    . VAL B 2 129 ? 15.048  -12.242 -43.361 1.00 18.15  ? 144 VAL H N    1 
ATOM   2133 C  CA   . VAL B 2 129 ? 14.569  -12.055 -44.721 1.00 18.04  ? 144 VAL H CA   1 
ATOM   2134 C  C    . VAL B 2 129 ? 15.481  -11.007 -45.337 1.00 17.56  ? 144 VAL H C    1 
ATOM   2135 O  O    . VAL B 2 129 ? 15.946  -10.105 -44.629 1.00 16.47  ? 144 VAL H O    1 
ATOM   2136 C  CB   . VAL B 2 129 ? 13.086  -11.637 -44.790 1.00 18.05  ? 144 VAL H CB   1 
ATOM   2137 C  CG1  . VAL B 2 129 ? 12.166  -12.694 -44.198 1.00 19.10  ? 144 VAL H CG1  1 
ATOM   2138 C  CG2  . VAL B 2 129 ? 12.823  -10.333 -44.077 1.00 19.23  ? 144 VAL H CG2  1 
ATOM   2139 N  N    . SER B 2 130 ? 15.717  -11.174 -46.637 1.00 16.65  ? 145 SER H N    1 
ATOM   2140 C  CA   . SER B 2 130 ? 16.762  -10.471 -47.349 1.00 17.78  ? 145 SER H CA   1 
ATOM   2141 C  C    . SER B 2 130 ? 16.326  -10.157 -48.766 1.00 17.06  ? 145 SER H C    1 
ATOM   2142 O  O    . SER B 2 130 ? 15.586  -10.920 -49.359 1.00 18.24  ? 145 SER H O    1 
ATOM   2143 C  CB   . SER B 2 130 ? 18.047  -11.270 -47.377 1.00 18.50  ? 145 SER H CB   1 
ATOM   2144 O  OG   . SER B 2 130 ? 17.818  -12.570 -47.886 1.00 18.74  ? 145 SER H OG   1 
ATOM   2145 N  N    . GLY B 2 131 ? 16.862  -9.062  -49.308 1.00 16.93  ? 146 GLY H N    1 
ATOM   2146 C  CA   . GLY B 2 131 ? 16.638  -8.722  -50.695 1.00 16.63  ? 146 GLY H CA   1 
ATOM   2147 C  C    . GLY B 2 131 ? 17.168  -7.347  -51.093 1.00 16.21  ? 146 GLY H C    1 
ATOM   2148 O  O    . GLY B 2 131 ? 17.620  -6.568  -50.264 1.00 15.50  ? 146 GLY H O    1 
ATOM   2149 N  N    . TRP B 2 132 ? 17.023  -7.080  -52.395 1.00 16.96  ? 147 TRP H N    1 
ATOM   2150 C  CA   . TRP B 2 132 ? 17.383  -5.840  -53.043 1.00 17.11  ? 147 TRP H CA   1 
ATOM   2151 C  C    . TRP B 2 132 ? 16.153  -5.005  -53.379 1.00 19.08  ? 147 TRP H C    1 
ATOM   2152 O  O    . TRP B 2 132 ? 16.179  -4.232  -54.336 1.00 17.08  ? 147 TRP H O    1 
ATOM   2153 C  CB   . TRP B 2 132 ? 18.115  -6.180  -54.341 1.00 16.64  ? 147 TRP H CB   1 
ATOM   2154 C  CG   . TRP B 2 132 ? 19.534  -6.618  -54.162 1.00 15.68  ? 147 TRP H CG   1 
ATOM   2155 C  CD1  . TRP B 2 132 ? 20.622  -5.836  -53.922 1.00 15.13  ? 147 TRP H CD1  1 
ATOM   2156 C  CD2  . TRP B 2 132 ? 20.014  -7.970  -54.271 1.00 14.91  ? 147 TRP H CD2  1 
ATOM   2157 N  NE1  . TRP B 2 132 ? 21.752  -6.608  -53.901 1.00 15.53  ? 147 TRP H NE1  1 
ATOM   2158 C  CE2  . TRP B 2 132 ? 21.408  -7.919  -54.100 1.00 15.06  ? 147 TRP H CE2  1 
ATOM   2159 C  CE3  . TRP B 2 132 ? 19.401  -9.193  -54.510 1.00 14.67  ? 147 TRP H CE3  1 
ATOM   2160 C  CZ2  . TRP B 2 132 ? 22.192  -9.062  -54.137 1.00 16.98  ? 147 TRP H CZ2  1 
ATOM   2161 C  CZ3  . TRP B 2 132 ? 20.172  -10.325 -54.550 1.00 15.76  ? 147 TRP H CZ3  1 
ATOM   2162 C  CH2  . TRP B 2 132 ? 21.550  -10.262 -54.376 1.00 17.39  ? 147 TRP H CH2  1 
ATOM   2163 N  N    . GLY B 2 133 ? 15.066  -5.198  -52.617 1.00 22.83  ? 148 GLY H N    1 
ATOM   2164 C  CA   . GLY B 2 133 ? 13.793  -4.539  -52.885 1.00 21.26  ? 148 GLY H CA   1 
ATOM   2165 C  C    . GLY B 2 133 ? 13.719  -3.149  -52.256 1.00 19.60  ? 148 GLY H C    1 
ATOM   2166 O  O    . GLY B 2 133 ? 14.731  -2.594  -51.860 1.00 18.84  ? 148 GLY H O    1 
ATOM   2167 N  N    . GLN B 2 134 ? 12.503  -2.609  -52.168 1.00 20.07  ? 149 GLN H N    1 
ATOM   2168 C  CA   . GLN B 2 134 ? 12.311  -1.197  -51.875 1.00 22.55  ? 149 GLN H CA   1 
ATOM   2169 C  C    . GLN B 2 134 ? 12.682  -0.881  -50.420 1.00 21.08  ? 149 GLN H C    1 
ATOM   2170 O  O    . GLN B 2 134 ? 12.303  -1.610  -49.511 1.00 18.10  ? 149 GLN H O    1 
ATOM   2171 C  CB   . GLN B 2 134 ? 10.877  -0.785  -52.186 1.00 22.03  ? 149 GLN H CB   1 
ATOM   2172 C  CG   . GLN B 2 134 ? 10.571  -0.754  -53.679 1.00 23.45  ? 149 GLN H CG   1 
ATOM   2173 C  CD   . GLN B 2 134 ? 9.177   -0.231  -53.941 1.00 25.01  ? 149 GLN H CD   1 
ATOM   2174 O  OE1  . GLN B 2 134 ? 8.345   -0.132  -53.048 1.00 30.00  ? 149 GLN H OE1  1 
ATOM   2175 N  NE2  . GLN B 2 134 ? 8.900   0.147   -55.168 1.00 25.53  ? 149 GLN H NE2  1 
ATOM   2176 N  N    . LEU B 2 135 ? 13.426  0.224   -50.231 1.00 20.95  ? 150 LEU H N    1 
ATOM   2177 C  CA   . LEU B 2 135 ? 13.909  0.635   -48.919 1.00 22.45  ? 150 LEU H CA   1 
ATOM   2178 C  C    . LEU B 2 135 ? 12.770  1.266   -48.150 1.00 25.10  ? 150 LEU H C    1 
ATOM   2179 O  O    . LEU B 2 135 ? 12.847  1.426   -46.940 1.00 28.28  ? 150 LEU H O    1 
ATOM   2180 C  CB   . LEU B 2 135 ? 15.059  1.631   -49.093 1.00 21.16  ? 150 LEU H CB   1 
ATOM   2181 C  CG   . LEU B 2 135 ? 16.311  1.030   -49.720 1.00 20.63  ? 150 LEU H CG   1 
ATOM   2182 C  CD1  . LEU B 2 135 ? 17.220  2.110   -50.230 1.00 20.19  ? 150 LEU H CD1  1 
ATOM   2183 C  CD2  . LEU B 2 135 ? 17.036  0.157   -48.717 1.00 20.77  ? 150 LEU H CD2  1 
ATOM   2184 N  N    . LEU B 2 136 ? 11.767  1.700   -48.911 1.00 29.24  ? 151 LEU H N    1 
ATOM   2185 C  CA   . LEU B 2 136 ? 10.575  2.323   -48.382 1.00 32.91  ? 151 LEU H CA   1 
ATOM   2186 C  C    . LEU B 2 136 ? 9.443   1.975   -49.327 1.00 35.47  ? 151 LEU H C    1 
ATOM   2187 O  O    . LEU B 2 136 ? 9.690   1.700   -50.506 1.00 39.21  ? 151 LEU H O    1 
ATOM   2188 C  CB   . LEU B 2 136 ? 10.780  3.839   -48.308 1.00 36.39  ? 151 LEU H CB   1 
ATOM   2189 C  CG   . LEU B 2 136 ? 11.435  4.358   -47.031 1.00 42.74  ? 151 LEU H CG   1 
ATOM   2190 C  CD1  . LEU B 2 136 ? 11.323  5.860   -46.987 1.00 49.76  ? 151 LEU H CD1  1 
ATOM   2191 C  CD2  . LEU B 2 136 ? 10.803  3.751   -45.780 1.00 47.36  ? 151 LEU H CD2  1 
ATOM   2192 N  N    . ASP B 2 137 ? 8.218   2.009   -48.805 1.00 37.31  ? 152 ASP H N    1 
ATOM   2193 C  CA   . ASP B 2 137 ? 7.061   1.663   -49.603 1.00 42.79  ? 152 ASP H CA   1 
ATOM   2194 C  C    . ASP B 2 137 ? 6.999   2.552   -50.847 1.00 46.56  ? 152 ASP H C    1 
ATOM   2195 O  O    . ASP B 2 137 ? 6.918   2.038   -51.959 1.00 46.70  ? 152 ASP H O    1 
ATOM   2196 C  CB   . ASP B 2 137 ? 5.803   1.751   -48.742 1.00 46.00  ? 152 ASP H CB   1 
ATOM   2197 C  CG   . ASP B 2 137 ? 4.538   1.323   -49.458 1.00 47.72  ? 152 ASP H CG   1 
ATOM   2198 O  OD1  . ASP B 2 137 ? 4.641   0.738   -50.578 1.00 39.87  ? 152 ASP H OD1  1 
ATOM   2199 O  OD2  . ASP B 2 137 ? 3.463   1.593   -48.885 1.00 50.36  ? 152 ASP H OD2  1 
ATOM   2200 N  N    . ARG B 2 138 ? 7.090   3.878   -50.655 1.00 50.50  ? 153 ARG H N    1 
ATOM   2201 C  CA   . ARG B 2 138 ? 6.757   4.863   -51.684 1.00 68.60  ? 153 ARG H CA   1 
ATOM   2202 C  C    . ARG B 2 138 ? 6.856   4.248   -53.093 1.00 67.23  ? 153 ARG H C    1 
ATOM   2203 O  O    . ARG B 2 138 ? 7.989   4.151   -53.633 1.00 62.99  ? 153 ARG H O    1 
ATOM   2204 C  CB   . ARG B 2 138 ? 7.627   6.127   -51.600 1.00 83.99  ? 153 ARG H CB   1 
ATOM   2205 C  CG   . ARG B 2 138 ? 8.093   6.526   -50.205 1.00 99.00  ? 153 ARG H CG   1 
ATOM   2206 C  CD   . ARG B 2 138 ? 6.999   6.946   -49.238 1.00 114.19 ? 153 ARG H CD   1 
ATOM   2207 N  NE   . ARG B 2 138 ? 7.246   6.348   -47.930 1.00 131.47 ? 153 ARG H NE   1 
ATOM   2208 C  CZ   . ARG B 2 138 ? 6.491   5.407   -47.362 1.00 142.19 ? 153 ARG H CZ   1 
ATOM   2209 N  NH1  . ARG B 2 138 ? 6.945   4.740   -46.315 1.00 145.00 ? 153 ARG H NH1  1 
ATOM   2210 N  NH2  . ARG B 2 138 ? 5.314   5.083   -47.871 1.00 141.30 ? 153 ARG H NH2  1 
ATOM   2211 N  N    . GLY B 2 139 ? 9.611   3.717   -52.009 1.00 44.42  ? 154 GLY H N    1 
ATOM   2212 C  CA   . GLY B 2 139 ? 10.776  4.479   -52.467 1.00 40.29  ? 154 GLY H CA   1 
ATOM   2213 C  C    . GLY B 2 139 ? 11.569  3.638   -53.446 1.00 38.31  ? 154 GLY H C    1 
ATOM   2214 O  O    . GLY B 2 139 ? 10.982  2.921   -54.251 1.00 40.84  ? 154 GLY H O    1 
ATOM   2215 N  N    . ALA B 2 140 ? 12.896  3.714   -53.327 1.00 36.29  ? 155 ALA H N    1 
ATOM   2216 C  CA   . ALA B 2 140 ? 13.773  3.148   -54.329 1.00 31.77  ? 155 ALA H CA   1 
ATOM   2217 C  C    . ALA B 2 140 ? 14.226  1.771   -53.864 1.00 27.34  ? 155 ALA H C    1 
ATOM   2218 O  O    . ALA B 2 140 ? 13.945  1.380   -52.730 1.00 24.28  ? 155 ALA H O    1 
ATOM   2219 C  CB   . ALA B 2 140 ? 14.930  4.085   -54.569 1.00 33.02  ? 155 ALA H CB   1 
ATOM   2220 N  N    . THR B 2 141 ? 14.892  1.058   -54.785 1.00 23.49  ? 156 THR H N    1 
ATOM   2221 C  CA   . THR B 2 141 ? 15.479  -0.239  -54.520 1.00 21.94  ? 156 THR H CA   1 
ATOM   2222 C  C    . THR B 2 141 ? 16.936  -0.123  -54.053 1.00 21.79  ? 156 THR H C    1 
ATOM   2223 O  O    . THR B 2 141 ? 17.610  0.876   -54.257 1.00 22.61  ? 156 THR H O    1 
ATOM   2224 C  CB   . THR B 2 141 ? 15.401  -1.114  -55.770 1.00 21.07  ? 156 THR H CB   1 
ATOM   2225 O  OG1  . THR B 2 141 ? 16.097  -0.431  -56.810 1.00 22.46  ? 156 THR H OG1  1 
ATOM   2226 C  CG2  . THR B 2 141 ? 13.983  -1.438  -56.178 1.00 20.66  ? 156 THR H CG2  1 
ATOM   2227 N  N    . ALA B 2 142 ? 17.419  -1.207  -53.447 1.00 20.94  ? 157 ALA H N    1 
ATOM   2228 C  CA   . ALA B 2 142 ? 18.735  -1.275  -52.851 1.00 21.31  ? 157 ALA H CA   1 
ATOM   2229 C  C    . ALA B 2 142 ? 19.744  -1.701  -53.907 1.00 22.55  ? 157 ALA H C    1 
ATOM   2230 O  O    . ALA B 2 142 ? 19.436  -2.496  -54.796 1.00 24.99  ? 157 ALA H O    1 
ATOM   2231 C  CB   . ALA B 2 142 ? 18.728  -2.260  -51.702 1.00 20.10  ? 157 ALA H CB   1 
ATOM   2232 N  N    . LEU B 2 143 ? 20.966  -1.197  -53.762 1.00 21.94  ? 158 LEU H N    1 
ATOM   2233 C  CA   . LEU B 2 143 ? 22.076  -1.635  -54.587 1.00 22.25  ? 158 LEU H CA   1 
ATOM   2234 C  C    . LEU B 2 143 ? 22.828  -2.763  -53.882 1.00 20.92  ? 158 LEU H C    1 
ATOM   2235 O  O    . LEU B 2 143 ? 23.387  -3.652  -54.524 1.00 19.59  ? 158 LEU H O    1 
ATOM   2236 C  CB   . LEU B 2 143 ? 22.948  -0.408  -54.863 1.00 21.46  ? 158 LEU H CB   1 
ATOM   2237 C  CG   . LEU B 2 143 ? 22.254  0.574   -55.794 1.00 22.54  ? 158 LEU H CG   1 
ATOM   2238 C  CD1  . LEU B 2 143 ? 22.734  2.000   -55.612 1.00 22.98  ? 158 LEU H CD1  1 
ATOM   2239 C  CD2  . LEU B 2 143 ? 22.436  0.136   -57.239 1.00 23.20  ? 158 LEU H CD2  1 
ATOM   2240 N  N    . GLU B 2 144 ? 22.842  -2.705  -52.553 1.00 19.93  ? 159 GLU H N    1 
ATOM   2241 C  CA   . GLU B 2 144 ? 23.536  -3.714  -51.780 1.00 20.63  ? 159 GLU H CA   1 
ATOM   2242 C  C    . GLU B 2 144 ? 22.490  -4.564  -51.079 1.00 19.79  ? 159 GLU H C    1 
ATOM   2243 O  O    . GLU B 2 144 ? 21.494  -4.022  -50.608 1.00 18.19  ? 159 GLU H O    1 
ATOM   2244 C  CB   . GLU B 2 144 ? 24.460  -3.072  -50.749 1.00 20.79  ? 159 GLU H CB   1 
ATOM   2245 C  CG   . GLU B 2 144 ? 25.748  -2.521  -51.302 1.00 21.98  ? 159 GLU H CG   1 
ATOM   2246 C  CD   . GLU B 2 144 ? 26.637  -2.054  -50.168 1.00 26.04  ? 159 GLU H CD   1 
ATOM   2247 O  OE1  . GLU B 2 144 ? 26.357  -0.950  -49.623 1.00 30.90  ? 159 GLU H OE1  1 
ATOM   2248 O  OE2  . GLU B 2 144 ? 27.523  -2.841  -49.754 1.00 27.87  ? 159 GLU H OE2  1 
ATOM   2249 N  N    . LEU B 2 145 ? 22.761  -5.875  -50.998 1.00 19.30  ? 160 LEU H N    1 
ATOM   2250 C  CA   . LEU B 2 145 ? 21.826  -6.828  -50.439 1.00 19.03  ? 160 LEU H CA   1 
ATOM   2251 C  C    . LEU B 2 145 ? 21.490  -6.382  -49.016 1.00 18.19  ? 160 LEU H C    1 
ATOM   2252 O  O    . LEU B 2 145 ? 22.386  -6.010  -48.269 1.00 18.92  ? 160 LEU H O    1 
ATOM   2253 C  CB   . LEU B 2 145 ? 22.466  -8.212  -50.526 1.00 20.09  ? 160 LEU H CB   1 
ATOM   2254 C  CG   . LEU B 2 145 ? 21.657  -9.372  -49.960 1.00 22.14  ? 160 LEU H CG   1 
ATOM   2255 C  CD1  . LEU B 2 145 ? 20.271  -9.445  -50.593 1.00 23.66  ? 160 LEU H CD1  1 
ATOM   2256 C  CD2  . LEU B 2 145 ? 22.386  -10.678 -50.183 1.00 21.88  ? 160 LEU H CD2  1 
ATOM   2257 N  N    . MET B 2 146 ? 20.190  -6.270  -48.710 1.00 16.09  ? 161 MET H N    1 
ATOM   2258 C  CA   . MET B 2 146 ? 19.738  -5.846  -47.397 1.00 16.38  ? 161 MET H CA   1 
ATOM   2259 C  C    . MET B 2 146 ? 19.115  -7.042  -46.678 1.00 15.65  ? 161 MET H C    1 
ATOM   2260 O  O    . MET B 2 146 ? 18.621  -7.970  -47.309 1.00 14.24  ? 161 MET H O    1 
ATOM   2261 C  CB   . MET B 2 146 ? 18.695  -4.725  -47.493 1.00 16.21  ? 161 MET H CB   1 
ATOM   2262 C  CG   . MET B 2 146 ? 19.178  -3.545  -48.329 1.00 17.38  ? 161 MET H CG   1 
ATOM   2263 S  SD   . MET B 2 146 ? 20.577  -2.559  -47.722 1.00 14.10  ? 161 MET H SD   1 
ATOM   2264 C  CE   . MET B 2 146 ? 19.799  -2.089  -46.188 1.00 13.63  ? 161 MET H CE   1 
ATOM   2265 N  N    . VAL B 2 147 ? 19.139  -7.005  -45.346 1.00 16.01  ? 162 VAL H N    1 
ATOM   2266 C  CA   . VAL B 2 147 ? 18.685  -8.130  -44.546 1.00 15.79  ? 162 VAL H CA   1 
ATOM   2267 C  C    . VAL B 2 147 ? 18.080  -7.623  -43.242 1.00 16.09  ? 162 VAL H C    1 
ATOM   2268 O  O    . VAL B 2 147 ? 18.450  -6.575  -42.730 1.00 16.84  ? 162 VAL H O    1 
ATOM   2269 C  CB   . VAL B 2 147 ? 19.838  -9.112  -44.279 1.00 14.74  ? 162 VAL H CB   1 
ATOM   2270 C  CG1  . VAL B 2 147 ? 20.915  -8.491  -43.411 1.00 14.36  ? 162 VAL H CG1  1 
ATOM   2271 C  CG2  . VAL B 2 147 ? 19.351  -10.419 -43.687 1.00 14.10  ? 162 VAL H CG2  1 
ATOM   2272 N  N    . LEU B 2 148 ? 17.147  -8.399  -42.711 1.00 16.70  ? 163 LEU H N    1 
ATOM   2273 C  CA   . LEU B 2 148 ? 16.323  -7.984  -41.602 1.00 17.54  ? 163 LEU H CA   1 
ATOM   2274 C  C    . LEU B 2 148 ? 15.928  -9.200  -40.772 1.00 18.15  ? 163 LEU H C    1 
ATOM   2275 O  O    . LEU B 2 148 ? 15.695  -10.290 -41.292 1.00 19.67  ? 163 LEU H O    1 
ATOM   2276 C  CB   . LEU B 2 148 ? 15.093  -7.310  -42.202 1.00 17.77  ? 163 LEU H CB   1 
ATOM   2277 C  CG   . LEU B 2 148 ? 13.971  -6.981  -41.227 1.00 17.34  ? 163 LEU H CG   1 
ATOM   2278 C  CD1  . LEU B 2 148 ? 14.408  -5.910  -40.249 1.00 17.76  ? 163 LEU H CD1  1 
ATOM   2279 C  CD2  . LEU B 2 148 ? 12.754  -6.546  -42.004 1.00 17.20  ? 163 LEU H CD2  1 
ATOM   2280 N  N    . ASN B 2 149 ? 15.829  -8.971  -39.480 1.00 18.94  ? 164 ASN H N    1 
ATOM   2281 C  CA   . ASN B 2 149 ? 15.362  -9.956  -38.531 1.00 21.49  ? 164 ASN H CA   1 
ATOM   2282 C  C    . ASN B 2 149 ? 13.866  -9.741  -38.316 1.00 19.79  ? 164 ASN H C    1 
ATOM   2283 O  O    . ASN B 2 149 ? 13.478  -8.641  -37.934 1.00 19.21  ? 164 ASN H O    1 
ATOM   2284 C  CB   . ASN B 2 149 ? 16.154  -9.796  -37.232 1.00 23.95  ? 164 ASN H CB   1 
ATOM   2285 C  CG   . ASN B 2 149 ? 16.386  -11.130 -36.569 1.00 34.38  ? 164 ASN H CG   1 
ATOM   2286 O  OD1  . ASN B 2 149 ? 16.107  -12.163 -37.172 1.00 46.14  ? 164 ASN H OD1  1 
ATOM   2287 N  ND2  . ASN B 2 149 ? 16.887  -11.136 -35.341 1.00 39.93  ? 164 ASN H ND2  1 
ATOM   2288 N  N    . VAL B 2 150 ? 13.027  -10.767 -38.545 1.00 20.35  ? 165 VAL H N    1 
ATOM   2289 C  CA   . VAL B 2 150 ? 11.599  -10.650 -38.283 1.00 19.59  ? 165 VAL H CA   1 
ATOM   2290 C  C    . VAL B 2 150 ? 11.093  -11.765 -37.366 1.00 18.68  ? 165 VAL H C    1 
ATOM   2291 O  O    . VAL B 2 150 ? 11.461  -12.935 -37.513 1.00 17.87  ? 165 VAL H O    1 
ATOM   2292 C  CB   . VAL B 2 150 ? 10.780  -10.615 -39.583 1.00 22.89  ? 165 VAL H CB   1 
ATOM   2293 C  CG1  . VAL B 2 150 ? 10.962  -9.302  -40.335 1.00 23.96  ? 165 VAL H CG1  1 
ATOM   2294 C  CG2  . VAL B 2 150 ? 11.057  -11.809 -40.487 1.00 23.26  ? 165 VAL H CG2  1 
ATOM   2295 N  N    . PRO B 2 151 ? 10.141  -11.438 -36.451 1.00 16.99  ? 166 PRO H N    1 
ATOM   2296 C  CA   . PRO B 2 151 ? 9.512   -12.432 -35.579 1.00 15.53  ? 166 PRO H CA   1 
ATOM   2297 C  C    . PRO B 2 151 ? 8.285   -13.106 -36.199 1.00 14.31  ? 166 PRO H C    1 
ATOM   2298 O  O    . PRO B 2 151 ? 7.511   -12.491 -36.905 1.00 12.58  ? 166 PRO H O    1 
ATOM   2299 C  CB   . PRO B 2 151 ? 9.084   -11.608 -34.368 1.00 15.03  ? 166 PRO H CB   1 
ATOM   2300 C  CG   . PRO B 2 151 ? 8.861   -10.211 -34.902 1.00 15.79  ? 166 PRO H CG   1 
ATOM   2301 C  CD   . PRO B 2 151 ? 9.615   -10.085 -36.208 1.00 15.96  ? 166 PRO H CD   1 
ATOM   2302 N  N    . ARG B 2 152 ? 8.108   -14.394 -35.938 1.00 14.25  ? 167 ARG H N    1 
ATOM   2303 C  CA   . ARG B 2 152 ? 7.055   -15.142 -36.594 1.00 15.34  ? 167 ARG H CA   1 
ATOM   2304 C  C    . ARG B 2 152 ? 5.808   -15.102 -35.716 1.00 16.73  ? 167 ARG H C    1 
ATOM   2305 O  O    . ARG B 2 152 ? 5.931   -14.984 -34.500 1.00 16.68  ? 167 ARG H O    1 
ATOM   2306 C  CB   . ARG B 2 152 ? 7.544   -16.567 -36.860 1.00 15.32  ? 167 ARG H CB   1 
ATOM   2307 C  CG   . ARG B 2 152 ? 6.604   -17.385 -37.726 1.00 16.37  ? 167 ARG H CG   1 
ATOM   2308 C  CD   . ARG B 2 152 ? 7.137   -18.741 -38.102 1.00 17.02  ? 167 ARG H CD   1 
ATOM   2309 N  NE   . ARG B 2 152 ? 6.081   -19.625 -38.538 1.00 17.70  ? 167 ARG H NE   1 
ATOM   2310 C  CZ   . ARG B 2 152 ? 6.273   -20.714 -39.259 1.00 19.67  ? 167 ARG H CZ   1 
ATOM   2311 N  NH1  . ARG B 2 152 ? 7.493   -21.065 -39.625 1.00 20.06  ? 167 ARG H NH1  1 
ATOM   2312 N  NH2  . ARG B 2 152 ? 5.240   -21.445 -39.629 1.00 20.66  ? 167 ARG H NH2  1 
ATOM   2313 N  N    . LEU B 2 153 ? 4.630   -15.108 -36.345 1.00 17.86  ? 168 LEU H N    1 
ATOM   2314 C  CA   . LEU B 2 153 ? 3.369   -15.183 -35.621 1.00 20.54  ? 168 LEU H CA   1 
ATOM   2315 C  C    . LEU B 2 153 ? 2.561   -16.378 -36.093 1.00 19.50  ? 168 LEU H C    1 
ATOM   2316 O  O    . LEU B 2 153 ? 2.538   -16.721 -37.255 1.00 19.25  ? 168 LEU H O    1 
ATOM   2317 C  CB   . LEU B 2 153 ? 2.520   -13.929 -35.864 1.00 24.45  ? 168 LEU H CB   1 
ATOM   2318 C  CG   . LEU B 2 153 ? 2.960   -12.660 -35.147 1.00 27.51  ? 168 LEU H CG   1 
ATOM   2319 C  CD1  . LEU B 2 153 ? 3.957   -11.898 -35.991 1.00 31.74  ? 168 LEU H CD1  1 
ATOM   2320 C  CD2  . LEU B 2 153 ? 1.782   -11.767 -34.846 1.00 28.38  ? 168 LEU H CD2  1 
ATOM   2321 N  N    . MET B 2 154 ? 1.802   -16.958 -35.178 1.00 21.17  ? 169 MET H N    1 
ATOM   2322 C  CA   . MET B 2 154 ? 0.767   -17.889 -35.572 1.00 20.20  ? 169 MET H CA   1 
ATOM   2323 C  C    . MET B 2 154 ? -0.406  -17.126 -36.173 1.00 18.37  ? 169 MET H C    1 
ATOM   2324 O  O    . MET B 2 154 ? -0.686  -15.987 -35.810 1.00 18.73  ? 169 MET H O    1 
ATOM   2325 C  CB   . MET B 2 154 ? 0.387   -18.715 -34.344 1.00 22.64  ? 169 MET H CB   1 
ATOM   2326 C  CG   . MET B 2 154 ? 1.452   -19.750 -34.123 1.00 25.23  ? 169 MET H CG   1 
ATOM   2327 S  SD   . MET B 2 154 ? 0.967   -21.107 -33.124 1.00 31.64  ? 169 MET H SD   1 
ATOM   2328 C  CE   . MET B 2 154 ? -0.042  -21.976 -34.315 1.00 35.54  ? 169 MET H CE   1 
ATOM   2329 N  N    . THR B 2 155 ? -1.099  -17.749 -37.112 1.00 17.51  ? 170 THR H N    1 
ATOM   2330 C  CA   . THR B 2 155 ? -2.114  -17.038 -37.870 1.00 18.12  ? 170 THR H CA   1 
ATOM   2331 C  C    . THR B 2 155 ? -3.207  -16.427 -36.976 1.00 20.51  ? 170 THR H C    1 
ATOM   2332 O  O    . THR B 2 155 ? -3.615  -15.286 -37.207 1.00 23.74  ? 170 THR H O    1 
ATOM   2333 C  CB   . THR B 2 155 ? -2.678  -17.949 -38.960 1.00 17.75  ? 170 THR H CB   1 
ATOM   2334 O  OG1  . THR B 2 155 ? -1.575  -18.321 -39.778 1.00 16.71  ? 170 THR H OG1  1 
ATOM   2335 C  CG2  . THR B 2 155 ? -3.716  -17.259 -39.810 1.00 18.50  ? 170 THR H CG2  1 
ATOM   2336 N  N    . GLN B 2 156 ? -3.696  -17.173 -35.972 1.00 21.11  ? 171 GLN H N    1 
ATOM   2337 C  CA   . GLN B 2 156 ? -4.719  -16.706 -35.038 1.00 20.45  ? 171 GLN H CA   1 
ATOM   2338 C  C    . GLN B 2 156 ? -4.290  -15.369 -34.435 1.00 20.84  ? 171 GLN H C    1 
ATOM   2339 O  O    . GLN B 2 156 ? -5.072  -14.411 -34.432 1.00 20.26  ? 171 GLN H O    1 
ATOM   2340 C  CB   . GLN B 2 156 ? -4.974  -17.812 -34.012 1.00 22.63  ? 171 GLN H CB   1 
ATOM   2341 C  CG   . GLN B 2 156 ? -6.020  -17.540 -32.928 1.00 25.10  ? 171 GLN H CG   1 
ATOM   2342 C  CD   . GLN B 2 156 ? -6.115  -18.699 -31.945 1.00 26.89  ? 171 GLN H CD   1 
ATOM   2343 O  OE1  . GLN B 2 156 ? -6.347  -19.856 -32.317 1.00 25.36  ? 171 GLN H OE1  1 
ATOM   2344 N  NE2  . GLN B 2 156 ? -5.841  -18.423 -30.674 1.00 26.79  ? 171 GLN H NE2  1 
ATOM   2345 N  N    . ASP B 2 157 ? -3.035  -15.277 -33.982 1.00 19.39  ? 172 ASP H N    1 
ATOM   2346 C  CA   . ASP B 2 157 ? -2.531  -14.021 -33.456 1.00 20.38  ? 172 ASP H CA   1 
ATOM   2347 C  C    . ASP B 2 157 ? -2.342  -12.967 -34.540 1.00 20.15  ? 172 ASP H C    1 
ATOM   2348 O  O    . ASP B 2 157 ? -2.487  -11.795 -34.253 1.00 19.49  ? 172 ASP H O    1 
ATOM   2349 C  CB   . ASP B 2 157 ? -1.182  -14.168 -32.768 1.00 21.35  ? 172 ASP H CB   1 
ATOM   2350 C  CG   . ASP B 2 157 ? -1.246  -14.944 -31.475 1.00 21.47  ? 172 ASP H CG   1 
ATOM   2351 O  OD1  . ASP B 2 157 ? -2.213  -14.728 -30.715 1.00 23.73  ? 172 ASP H OD1  1 
ATOM   2352 O  OD2  . ASP B 2 157 ? -0.324  -15.738 -31.247 1.00 21.16  ? 172 ASP H OD2  1 
ATOM   2353 N  N    . CYS B 2 158 ? -1.966  -13.364 -35.762 1.00 22.42  ? 173 CYS H N    1 
ATOM   2354 C  CA   . CYS B 2 158 ? -1.826  -12.420 -36.868 1.00 22.46  ? 173 CYS H CA   1 
ATOM   2355 C  C    . CYS B 2 158 ? -3.165  -11.768 -37.242 1.00 22.58  ? 173 CYS H C    1 
ATOM   2356 O  O    . CYS B 2 158 ? -3.198  -10.575 -37.510 1.00 22.43  ? 173 CYS H O    1 
ATOM   2357 C  CB   . CYS B 2 158 ? -1.220  -13.067 -38.109 1.00 21.23  ? 173 CYS H CB   1 
ATOM   2358 S  SG   . CYS B 2 158 ? -0.934  -11.893 -39.462 1.00 19.19  ? 173 CYS H SG   1 
ATOM   2359 N  N    . LEU B 2 159 ? -4.255  -12.542 -37.292 1.00 24.75  ? 174 LEU H N    1 
ATOM   2360 C  CA   . LEU B 2 159 ? -5.585  -11.983 -37.549 1.00 26.96  ? 174 LEU H CA   1 
ATOM   2361 C  C    . LEU B 2 159 ? -6.003  -11.069 -36.395 1.00 29.61  ? 174 LEU H C    1 
ATOM   2362 O  O    . LEU B 2 159 ? -6.432  -9.949  -36.639 1.00 32.19  ? 174 LEU H O    1 
ATOM   2363 C  CB   . LEU B 2 159 ? -6.628  -13.094 -37.744 1.00 25.03  ? 174 LEU H CB   1 
ATOM   2364 C  CG   . LEU B 2 159 ? -6.325  -14.152 -38.803 1.00 24.79  ? 174 LEU H CG   1 
ATOM   2365 C  CD1  . LEU B 2 159 ? -7.456  -15.166 -38.901 1.00 26.65  ? 174 LEU H CD1  1 
ATOM   2366 C  CD2  . LEU B 2 159 ? -6.080  -13.520 -40.155 1.00 24.01  ? 174 LEU H CD2  1 
ATOM   2367 N  N    . GLN B 2 160 ? -5.816  -11.507 -35.144 1.00 33.13  ? 175 GLN H N    1 
ATOM   2368 C  CA   . GLN B 2 160 ? -6.403  -10.825 -33.995 1.00 40.63  ? 175 GLN H CA   1 
ATOM   2369 C  C    . GLN B 2 160 ? -5.651  -9.531  -33.676 1.00 37.55  ? 175 GLN H C    1 
ATOM   2370 O  O    . GLN B 2 160 ? -5.864  -8.914  -32.649 1.00 48.00  ? 175 GLN H O    1 
ATOM   2371 C  CB   . GLN B 2 160 ? -6.458  -11.760 -32.774 1.00 44.97  ? 175 GLN H CB   1 
ATOM   2372 C  CG   . GLN B 2 160 ? -7.496  -12.888 -32.925 1.00 56.50  ? 175 GLN H CG   1 
ATOM   2373 C  CD   . GLN B 2 160 ? -7.597  -13.898 -31.794 1.00 56.41  ? 175 GLN H CD   1 
ATOM   2374 O  OE1  . GLN B 2 160 ? -8.509  -14.730 -31.750 1.00 57.69  ? 175 GLN H OE1  1 
ATOM   2375 N  NE2  . GLN B 2 160 ? -6.662  -13.844 -30.858 1.00 50.87  ? 175 GLN H NE2  1 
ATOM   2376 N  N    . GLN B 2 161 ? -4.827  -9.052  -34.589 1.00 38.55  ? 176 GLN H N    1 
ATOM   2377 C  CA   . GLN B 2 161 ? -3.732  -8.167  -34.221 1.00 37.58  ? 176 GLN H CA   1 
ATOM   2378 C  C    . GLN B 2 161 ? -3.320  -7.329  -35.430 1.00 36.75  ? 176 GLN H C    1 
ATOM   2379 O  O    . GLN B 2 161 ? -2.745  -6.262  -35.290 1.00 33.91  ? 176 GLN H O    1 
ATOM   2380 C  CB   . GLN B 2 161 ? -2.610  -9.035  -33.675 1.00 36.06  ? 176 GLN H CB   1 
ATOM   2381 C  CG   . GLN B 2 161 ? -1.390  -8.271  -33.213 1.00 41.25  ? 176 GLN H CG   1 
ATOM   2382 C  CD   . GLN B 2 161 ? -0.483  -9.121  -32.350 1.00 45.16  ? 176 GLN H CD   1 
ATOM   2383 O  OE1  . GLN B 2 161 ? -0.878  -10.149 -31.806 1.00 50.16  ? 176 GLN H OE1  1 
ATOM   2384 N  NE2  . GLN B 2 161 ? 0.763   -8.697  -32.217 1.00 49.75  ? 176 GLN H NE2  1 
ATOM   2385 N  N    . SER B 2 162 ? -3.612  -7.853  -36.622 1.00 39.80  ? 177 SER H N    1 
ATOM   2386 C  CA   . SER B 2 162 ? -3.679  -7.068  -37.838 1.00 39.62  ? 177 SER H CA   1 
ATOM   2387 C  C    . SER B 2 162 ? -4.904  -6.175  -37.773 1.00 44.10  ? 177 SER H C    1 
ATOM   2388 O  O    . SER B 2 162 ? -5.950  -6.616  -37.302 1.00 40.21  ? 177 SER H O    1 
ATOM   2389 C  CB   . SER B 2 162 ? -3.743  -7.949  -39.068 1.00 35.30  ? 177 SER H CB   1 
ATOM   2390 O  OG   . SER B 2 162 ? -2.444  -8.239  -39.554 1.00 35.41  ? 177 SER H OG   1 
ATOM   2391 N  N    . ARG B 2 163 ? -4.737  -4.956  -38.301 1.00 49.40  ? 178 ARG H N    1 
ATOM   2392 C  CA   . ARG B 2 163 ? -5.804  -3.994  -38.509 1.00 54.81  ? 178 ARG H CA   1 
ATOM   2393 C  C    . ARG B 2 163 ? -6.647  -4.465  -39.689 1.00 54.79  ? 178 ARG H C    1 
ATOM   2394 O  O    . ARG B 2 163 ? -6.117  -4.834  -40.734 1.00 51.38  ? 178 ARG H O    1 
ATOM   2395 C  CB   . ARG B 2 163 ? -5.216  -2.592  -38.726 1.00 63.91  ? 178 ARG H CB   1 
ATOM   2396 C  CG   . ARG B 2 163 ? -6.231  -1.473  -38.943 1.00 77.30  ? 178 ARG H CG   1 
ATOM   2397 C  CD   . ARG B 2 163 ? -7.148  -1.219  -37.751 1.00 97.86  ? 178 ARG H CD   1 
ATOM   2398 N  NE   . ARG B 2 163 ? -6.428  -0.928  -36.506 1.00 116.92 ? 178 ARG H NE   1 
ATOM   2399 C  CZ   . ARG B 2 163 ? -6.896  -1.120  -35.267 1.00 107.14 ? 178 ARG H CZ   1 
ATOM   2400 N  NH1  . ARG B 2 163 ? -8.081  -1.670  -35.068 1.00 101.76 ? 178 ARG H NH1  1 
ATOM   2401 N  NH2  . ARG B 2 163 ? -6.163  -0.776  -34.220 1.00 100.42 ? 178 ARG H NH2  1 
ATOM   2402 N  N    . LYS B 2 164 ? -7.964  -4.434  -39.477 1.00 65.32  ? 179 LYS H N    1 
ATOM   2403 C  CA   . LYS B 2 164 ? -8.961  -5.012  -40.362 1.00 77.34  ? 179 LYS H CA   1 
ATOM   2404 C  C    . LYS B 2 164 ? -9.149  -4.092  -41.561 1.00 81.27  ? 179 LYS H C    1 
ATOM   2405 O  O    . LYS B 2 164 ? -9.064  -2.874  -41.415 1.00 89.75  ? 179 LYS H O    1 
ATOM   2406 C  CB   . LYS B 2 164 ? -10.264 -5.134  -39.571 1.00 88.73  ? 179 LYS H CB   1 
ATOM   2407 C  CG   . LYS B 2 164 ? -11.235 -6.213  -40.020 1.00 96.18  ? 179 LYS H CG   1 
ATOM   2408 C  CD   . LYS B 2 164 ? -12.441 -6.275  -39.104 1.00 98.81  ? 179 LYS H CD   1 
ATOM   2409 C  CE   . LYS B 2 164 ? -13.137 -7.619  -39.102 1.00 100.15 ? 179 LYS H CE   1 
ATOM   2410 N  NZ   . LYS B 2 164 ? -13.575 -8.009  -40.462 1.00 100.35 ? 179 LYS H NZ   1 
ATOM   2411 N  N    . VAL B 2 165 ? -9.424  -4.666  -42.734 1.00 80.70  ? 180 VAL H N    1 
ATOM   2412 C  CA   . VAL B 2 165 ? -9.357  -3.891  -43.965 1.00 86.25  ? 180 VAL H CA   1 
ATOM   2413 C  C    . VAL B 2 165 ? -10.206 -4.568  -45.042 1.00 85.61  ? 180 VAL H C    1 
ATOM   2414 O  O    . VAL B 2 165 ? -10.197 -5.794  -45.165 1.00 80.95  ? 180 VAL H O    1 
ATOM   2415 C  CB   . VAL B 2 165 ? -7.883  -3.704  -44.386 1.00 96.11  ? 180 VAL H CB   1 
ATOM   2416 C  CG1  . VAL B 2 165 ? -7.205  -5.036  -44.671 1.00 96.14  ? 180 VAL H CG1  1 
ATOM   2417 C  CG2  . VAL B 2 165 ? -7.720  -2.751  -45.561 1.00 97.54  ? 180 VAL H CG2  1 
ATOM   2418 N  N    . GLY B 2 166 ? -10.912 -3.736  -45.824 1.00 91.16  ? 181 GLY H N    1 
ATOM   2419 C  CA   . GLY B 2 166 ? -12.017 -4.155  -46.677 1.00 92.37  ? 181 GLY H CA   1 
ATOM   2420 C  C    . GLY B 2 166 ? -11.705 -5.357  -47.571 1.00 92.15  ? 181 GLY H C    1 
ATOM   2421 O  O    . GLY B 2 166 ? -12.492 -6.302  -47.607 1.00 84.53  ? 181 GLY H O    1 
ATOM   2422 N  N    . ASP B 2 167 ? -10.569 -5.319  -48.287 1.00 92.74  ? 182 ASP H N    1 
ATOM   2423 C  CA   . ASP B 2 167 ? -10.286 -6.292  -49.338 1.00 94.96  ? 182 ASP H CA   1 
ATOM   2424 C  C    . ASP B 2 167 ? -8.861  -6.846  -49.237 1.00 95.02  ? 182 ASP H C    1 
ATOM   2425 O  O    . ASP B 2 167 ? -8.127  -6.856  -50.229 1.00 83.70  ? 182 ASP H O    1 
ATOM   2426 C  CB   . ASP B 2 167 ? -10.494 -5.670  -50.724 1.00 101.14 ? 182 ASP H CB   1 
ATOM   2427 C  CG   . ASP B 2 167 ? -9.599  -4.467  -51.004 1.00 105.03 ? 182 ASP H CG   1 
ATOM   2428 O  OD1  . ASP B 2 167 ? -9.106  -3.856  -50.022 1.00 97.05  ? 182 ASP H OD1  1 
ATOM   2429 O  OD2  . ASP B 2 167 ? -9.372  -4.163  -52.205 1.00 93.60  ? 182 ASP H OD2  1 
ATOM   2430 N  N    . SER B 2 168 ? -8.479  -7.327  -48.045 1.00 91.15  ? 183 SER H N    1 
ATOM   2431 C  CA   . SER B 2 168 ? -7.249  -8.089  -47.886 1.00 80.16  ? 183 SER H CA   1 
ATOM   2432 C  C    . SER B 2 168 ? -7.553  -9.565  -48.109 1.00 63.59  ? 183 SER H C    1 
ATOM   2433 O  O    . SER B 2 168 ? -8.526  -10.060 -47.555 1.00 60.49  ? 183 SER H O    1 
ATOM   2434 C  CB   . SER B 2 168 ? -6.622  -7.862  -46.535 1.00 85.67  ? 183 SER H CB   1 
ATOM   2435 O  OG   . SER B 2 168 ? -5.859  -6.662  -46.543 1.00 94.33  ? 183 SER H OG   1 
ATOM   2436 N  N    . PRO B 2 169 ? -6.771  -10.302 -48.935 1.00 53.98  ? 184 PRO H N    1 
ATOM   2437 C  CA   . PRO B 2 169 ? -6.952  -11.748 -49.067 1.00 53.91  ? 184 PRO H CA   1 
ATOM   2438 C  C    . PRO B 2 169 ? -6.887  -12.451 -47.713 1.00 52.27  ? 184 PRO H C    1 
ATOM   2439 O  O    . PRO B 2 169 ? -6.320  -11.918 -46.762 1.00 47.63  ? 184 PRO H O    1 
ATOM   2440 C  CB   . PRO B 2 169 ? -5.788  -12.180 -49.972 1.00 56.61  ? 184 PRO H CB   1 
ATOM   2441 C  CG   . PRO B 2 169 ? -5.467  -10.932 -50.774 1.00 54.42  ? 184 PRO H CG   1 
ATOM   2442 C  CD   . PRO B 2 169 ? -5.711  -9.785  -49.817 1.00 53.64  ? 184 PRO H CD   1 
ATOM   2443 N  N    . ASN B 2 170 ? -7.491  -13.643 -47.640 1.00 53.41  ? 185 ASN H N    1 
ATOM   2444 C  CA   . ASN B 2 170 ? -7.383  -14.505 -46.471 1.00 54.18  ? 185 ASN H CA   1 
ATOM   2445 C  C    . ASN B 2 170 ? -5.934  -14.971 -46.293 1.00 43.42  ? 185 ASN H C    1 
ATOM   2446 O  O    . ASN B 2 170 ? -5.225  -15.184 -47.268 1.00 40.01  ? 185 ASN H O    1 
ATOM   2447 C  CB   . ASN B 2 170 ? -8.315  -15.717 -46.599 1.00 60.04  ? 185 ASN H CB   1 
ATOM   2448 C  CG   . ASN B 2 170 ? -9.773  -15.325 -46.716 1.00 64.94  ? 185 ASN H CG   1 
ATOM   2449 O  OD1  . ASN B 2 170 ? -10.127 -14.175 -46.462 1.00 64.87  ? 185 ASN H OD1  1 
ATOM   2450 N  ND2  . ASN B 2 170 ? -10.624 -16.272 -47.081 1.00 66.36  ? 185 ASN H ND2  1 
ATOM   2451 N  N    . ILE B 2 171 ? -5.495  -15.095 -45.038 1.00 36.82  ? 186 ILE H N    1 
ATOM   2452 C  CA   . ILE B 2 171 ? -4.291  -15.841 -44.720 1.00 34.24  ? 186 ILE H CA   1 
ATOM   2453 C  C    . ILE B 2 171 ? -4.689  -17.303 -44.767 1.00 28.20  ? 186 ILE H C    1 
ATOM   2454 O  O    . ILE B 2 171 ? -5.639  -17.654 -44.110 1.00 30.18  ? 186 ILE H O    1 
ATOM   2455 C  CB   . ILE B 2 171 ? -3.723  -15.504 -43.325 1.00 34.72  ? 186 ILE H CB   1 
ATOM   2456 C  CG1  . ILE B 2 171 ? -3.525  -14.006 -43.082 1.00 34.91  ? 186 ILE H CG1  1 
ATOM   2457 C  CG2  . ILE B 2 171 ? -2.441  -16.281 -43.078 1.00 34.65  ? 186 ILE H CG2  1 
ATOM   2458 C  CD1  . ILE B 2 171 ? -2.610  -13.346 -44.071 1.00 40.73  ? 186 ILE H CD1  1 
ATOM   2459 N  N    . THR B 2 172 ? -3.988  -18.126 -45.550 1.00 26.53  ? 187 THR H N    1 
ATOM   2460 C  CA   . THR B 2 172 ? -4.329  -19.534 -45.689 1.00 24.02  ? 187 THR H CA   1 
ATOM   2461 C  C    . THR B 2 172 ? -3.311  -20.350 -44.911 1.00 21.48  ? 187 THR H C    1 
ATOM   2462 O  O    . THR B 2 172 ? -2.440  -19.789 -44.260 1.00 27.02  ? 187 THR H O    1 
ATOM   2463 C  CB   . THR B 2 172 ? -4.446  -19.953 -47.166 1.00 23.68  ? 187 THR H CB   1 
ATOM   2464 O  OG1  . THR B 2 172 ? -3.171  -20.297 -47.721 1.00 22.72  ? 187 THR H OG1  1 
ATOM   2465 C  CG2  . THR B 2 172 ? -5.099  -18.874 -48.006 1.00 24.30  ? 187 THR H CG2  1 
ATOM   2466 N  N    . GLU B 2 173 ? -3.455  -21.666 -44.959 1.00 20.04  ? 188 GLU H N    1 
ATOM   2467 C  CA   . GLU B 2 173 ? -2.575  -22.563 -44.241 1.00 21.45  ? 188 GLU H CA   1 
ATOM   2468 C  C    . GLU B 2 173 ? -1.275  -22.744 -45.027 1.00 20.67  ? 188 GLU H C    1 
ATOM   2469 O  O    . GLU B 2 173 ? -0.358  -23.427 -44.543 1.00 20.54  ? 188 GLU H O    1 
ATOM   2470 C  CB   . GLU B 2 173 ? -3.302  -23.878 -43.939 1.00 24.72  ? 188 GLU H CB   1 
ATOM   2471 C  CG   . GLU B 2 173 ? -3.786  -24.638 -45.169 1.00 31.33  ? 188 GLU H CG   1 
ATOM   2472 C  CD   . GLU B 2 173 ? -5.216  -24.421 -45.679 1.00 38.14  ? 188 GLU H CD   1 
ATOM   2473 O  OE1  . GLU B 2 173 ? -5.743  -23.245 -45.671 1.00 35.39  ? 188 GLU H OE1  1 
ATOM   2474 O  OE2  . GLU B 2 173 ? -5.804  -25.433 -46.148 1.00 37.92  ? 188 GLU H OE2  1 
ATOM   2475 N  N    . TYR B 2 174 ? -1.226  -22.161 -46.245 1.00 18.62  ? 189 TYR H N    1 
ATOM   2476 C  CA   . TYR B 2 174 ? -0.031  -22.137 -47.074 1.00 19.64  ? 189 TYR H CA   1 
ATOM   2477 C  C    . TYR B 2 174 ? 0.766   -20.836 -46.880 1.00 18.37  ? 189 TYR H C    1 
ATOM   2478 O  O    . TYR B 2 174 ? 1.657   -20.493 -47.654 1.00 19.55  ? 189 TYR H O    1 
ATOM   2479 C  CB   . TYR B 2 174 ? -0.521  -22.350 -48.512 1.00 22.80  ? 189 TYR H CB   1 
ATOM   2480 C  CG   . TYR B 2 174 ? -1.267  -23.671 -48.686 1.00 25.81  ? 189 TYR H CG   1 
ATOM   2481 C  CD1  . TYR B 2 174 ? -0.603  -24.891 -48.637 1.00 25.37  ? 189 TYR H CD1  1 
ATOM   2482 C  CD2  . TYR B 2 174 ? -2.644  -23.693 -48.857 1.00 26.01  ? 189 TYR H CD2  1 
ATOM   2483 C  CE1  . TYR B 2 174 ? -1.286  -26.089 -48.768 1.00 26.74  ? 189 TYR H CE1  1 
ATOM   2484 C  CE2  . TYR B 2 174 ? -3.335  -24.883 -48.996 1.00 26.82  ? 189 TYR H CE2  1 
ATOM   2485 C  CZ   . TYR B 2 174 ? -2.660  -26.085 -48.931 1.00 26.35  ? 189 TYR H CZ   1 
ATOM   2486 O  OH   . TYR B 2 174 ? -3.367  -27.242 -49.041 1.00 24.36  ? 189 TYR H OH   1 
ATOM   2487 N  N    . MET B 2 175 ? 0.457   -20.109 -45.820 1.00 17.00  ? 190 MET H N    1 
ATOM   2488 C  CA   . MET B 2 175 ? 1.016   -18.808 -45.552 1.00 16.54  ? 190 MET H CA   1 
ATOM   2489 C  C    . MET B 2 175 ? 1.311   -18.742 -44.054 1.00 15.83  ? 190 MET H C    1 
ATOM   2490 O  O    . MET B 2 175 ? 0.784   -19.542 -43.277 1.00 13.83  ? 190 MET H O    1 
ATOM   2491 C  CB   . MET B 2 175 ? -0.002  -17.711 -45.882 1.00 17.53  ? 190 MET H CB   1 
ATOM   2492 C  CG   . MET B 2 175 ? -0.456  -17.651 -47.317 1.00 17.05  ? 190 MET H CG   1 
ATOM   2493 S  SD   . MET B 2 175 ? -1.599  -16.249 -47.575 1.00 16.45  ? 190 MET H SD   1 
ATOM   2494 C  CE   . MET B 2 175 ? -2.204  -16.721 -49.194 1.00 18.02  ? 190 MET H CE   1 
ATOM   2495 N  N    . PHE B 2 176 ? 2.149   -17.772 -43.667 1.00 15.54  ? 191 PHE H N    1 
ATOM   2496 C  CA   . PHE B 2 176 ? 2.333   -17.411 -42.276 1.00 14.69  ? 191 PHE H CA   1 
ATOM   2497 C  C    . PHE B 2 176 ? 2.722   -15.939 -42.218 1.00 14.96  ? 191 PHE H C    1 
ATOM   2498 O  O    . PHE B 2 176 ? 3.219   -15.388 -43.201 1.00 13.43  ? 191 PHE H O    1 
ATOM   2499 C  CB   . PHE B 2 176 ? 3.347   -18.339 -41.617 1.00 15.68  ? 191 PHE H CB   1 
ATOM   2500 C  CG   . PHE B 2 176 ? 4.805   -18.163 -42.000 1.00 16.54  ? 191 PHE H CG   1 
ATOM   2501 C  CD1  . PHE B 2 176 ? 5.588   -17.152 -41.439 1.00 15.52  ? 191 PHE H CD1  1 
ATOM   2502 C  CD2  . PHE B 2 176 ? 5.424   -19.077 -42.838 1.00 16.49  ? 191 PHE H CD2  1 
ATOM   2503 C  CE1  . PHE B 2 176 ? 6.934   -17.031 -41.747 1.00 14.86  ? 191 PHE H CE1  1 
ATOM   2504 C  CE2  . PHE B 2 176 ? 6.770   -18.942 -43.149 1.00 16.45  ? 191 PHE H CE2  1 
ATOM   2505 C  CZ   . PHE B 2 176 ? 7.519   -17.923 -42.604 1.00 15.17  ? 191 PHE H CZ   1 
ATOM   2506 N  N    . CYS B 2 177 ? 2.414   -15.291 -41.085 1.00 15.25  ? 192 CYS H N    1 
ATOM   2507 C  CA   . CYS B 2 177 ? 2.729   -13.885 -40.946 1.00 16.50  ? 192 CYS H CA   1 
ATOM   2508 C  C    . CYS B 2 177 ? 4.126   -13.757 -40.345 1.00 16.21  ? 192 CYS H C    1 
ATOM   2509 O  O    . CYS B 2 177 ? 4.401   -14.562 -39.426 1.00 16.26  ? 192 CYS H O    1 
ATOM   2510 C  CB   . CYS B 2 177 ? 1.701   -13.164 -40.087 1.00 17.48  ? 192 CYS H CB   1 
ATOM   2511 S  SG   . CYS B 2 177 ? 0.069   -13.016 -40.860 1.00 19.13  ? 192 CYS H SG   1 
ATOM   2512 N  N    . ALA B 2 178 ? 5.387   -12.305 -40.077 1.00 36.63  ? 193 ALA H N    1 
ATOM   2513 C  CA   . ALA B 2 178 ? 5.923   -10.932 -40.115 1.00 39.98  ? 193 ALA H CA   1 
ATOM   2514 C  C    . ALA B 2 178 ? 4.808   -9.892  -40.230 1.00 64.04  ? 193 ALA H C    1 
ATOM   2515 O  O    . ALA B 2 178 ? 5.031   -8.906  -40.983 1.00 76.88  ? 193 ALA H O    1 
ATOM   2516 C  CB   . ALA B 2 178 ? 6.814   -10.781 -41.289 1.00 43.71  ? 193 ALA H CB   1 
ATOM   2517 N  N    . GLY B 2 179 ? 7.352   -10.015 -38.847 1.00 34.25  ? 194 GLY H N    1 
ATOM   2518 C  CA   . GLY B 2 179 ? 7.272   -8.586  -39.210 1.00 39.22  ? 194 GLY H CA   1 
ATOM   2519 C  C    . GLY B 2 179 ? 7.231   -7.688  -37.979 1.00 42.91  ? 194 GLY H C    1 
ATOM   2520 O  O    . GLY B 2 179 ? 8.250   -7.100  -37.559 1.00 75.68  ? 194 GLY H O    1 
ATOM   2521 N  N    . TYR B 2 180 ? 6.049   -7.524  -37.420 1.00 45.85  ? 195 TYR H N    1 
ATOM   2522 C  CA   . TYR B 2 180 ? 6.071   -7.537  -35.971 1.00 72.88  ? 195 TYR H CA   1 
ATOM   2523 C  C    . TYR B 2 180 ? 6.234   -9.025  -35.681 1.00 62.95  ? 195 TYR H C    1 
ATOM   2524 O  O    . TYR B 2 180 ? 6.648   -9.588  -36.723 1.00 46.32  ? 195 TYR H O    1 
ATOM   2525 C  CB   . TYR B 2 180 ? 5.005   -6.990  -35.004 1.00 88.43  ? 195 TYR H CB   1 
ATOM   2526 C  CG   . TYR B 2 180 ? 5.374   -7.658  -33.691 1.00 102.19 ? 195 TYR H CG   1 
ATOM   2527 C  CD1  . TYR B 2 180 ? 6.545   -7.284  -33.038 1.00 113.47 ? 195 TYR H CD1  1 
ATOM   2528 C  CD2  . TYR B 2 180 ? 4.700   -8.787  -33.228 1.00 116.88 ? 195 TYR H CD2  1 
ATOM   2529 C  CE1  . TYR B 2 180 ? 6.973   -7.931  -31.893 1.00 113.06 ? 195 TYR H CE1  1 
ATOM   2530 C  CE2  . TYR B 2 180 ? 5.118   -9.446  -32.082 1.00 123.63 ? 195 TYR H CE2  1 
ATOM   2531 C  CZ   . TYR B 2 180 ? 6.254   -9.014  -31.414 1.00 123.60 ? 195 TYR H CZ   1 
ATOM   2532 O  OH   . TYR B 2 180 ? 6.665   -9.648  -30.281 1.00 126.00 ? 195 TYR H OH   1 
ATOM   2533 N  N    . SER B 2 181 ? 5.879   -5.197  -37.476 1.00 46.28  ? 196 SER H N    1 
ATOM   2534 C  CA   . SER B 2 181 ? 4.724   -4.268  -37.607 1.00 52.61  ? 196 SER H CA   1 
ATOM   2535 C  C    . SER B 2 181 ? 4.957   -3.054  -36.711 1.00 65.43  ? 196 SER H C    1 
ATOM   2536 O  O    . SER B 2 181 ? 6.062   -2.889  -36.189 1.00 87.20  ? 196 SER H O    1 
ATOM   2537 C  CB   . SER B 2 181 ? 3.402   -4.922  -37.287 1.00 57.33  ? 196 SER H CB   1 
ATOM   2538 O  OG   . SER B 2 181 ? 2.499   -4.041  -36.573 1.00 50.49  ? 196 SER H OG   1 
ATOM   2539 N  N    . ASP B 2 182 ? 3.919   -2.217  -36.543 1.00 43.34  ? 197 ASP H N    1 
ATOM   2540 C  CA   . ASP B 2 182 ? 4.100   -0.885  -35.990 1.00 39.03  ? 197 ASP H CA   1 
ATOM   2541 C  C    . ASP B 2 182 ? 4.761   0.045   -37.007 1.00 41.99  ? 197 ASP H C    1 
ATOM   2542 O  O    . ASP B 2 182 ? 5.258   1.101   -36.622 1.00 36.61  ? 197 ASP H O    1 
ATOM   2543 C  CB   . ASP B 2 182 ? 4.836   -0.845  -34.634 1.00 37.26  ? 197 ASP H CB   1 
ATOM   2544 C  CG   . ASP B 2 182 ? 6.334   -1.145  -34.568 1.00 36.61  ? 197 ASP H CG   1 
ATOM   2545 O  OD1  . ASP B 2 182 ? 7.004   -1.183  -35.581 1.00 31.39  ? 197 ASP H OD1  1 
ATOM   2546 O  OD2  . ASP B 2 182 ? 6.825   -1.375  -33.472 1.00 45.51  ? 197 ASP H OD2  1 
ATOM   2547 N  N    . GLY B 2 183 ? 4.730   -0.312  -38.302 1.00 45.02  ? 198 GLY H N    1 
ATOM   2548 C  CA   . GLY B 2 183 ? 4.931   0.674   -39.354 1.00 43.88  ? 198 GLY H CA   1 
ATOM   2549 C  C    . GLY B 2 183 ? 6.256   0.523   -40.084 1.00 52.73  ? 198 GLY H C    1 
ATOM   2550 O  O    . GLY B 2 183 ? 7.027   1.525   -40.183 1.00 48.94  ? 198 GLY H O    1 
ATOM   2551 N  N    . SER B 2 184 ? 8.405   0.944   -38.422 1.00 41.96  ? 199 SER H N    1 
ATOM   2552 C  CA   . SER B 2 184 ? 9.802   0.465   -38.385 1.00 36.70  ? 199 SER H CA   1 
ATOM   2553 C  C    . SER B 2 184 ? 10.106  -0.428  -39.575 1.00 37.96  ? 199 SER H C    1 
ATOM   2554 O  O    . SER B 2 184 ? 11.202  -0.325  -40.080 1.00 36.97  ? 199 SER H O    1 
ATOM   2555 C  CB   . SER B 2 184 ? 10.147  -0.145  -37.074 1.00 34.68  ? 199 SER H CB   1 
ATOM   2556 O  OG   . SER B 2 184 ? 9.219   -1.136  -36.733 1.00 33.95  ? 199 SER H OG   1 
ATOM   2557 N  N    . LYS B 2 185 ? 9.210   -1.299  -40.049 1.00 51.79  ? 200 LYS H N    1 
ATOM   2558 C  CA   . LYS B 2 185 ? 8.157   -1.992  -39.326 1.00 68.33  ? 200 LYS H CA   1 
ATOM   2559 C  C    . LYS B 2 185 ? 7.487   -1.105  -38.273 1.00 62.94  ? 200 LYS H C    1 
ATOM   2560 O  O    . LYS B 2 185 ? 7.125   0.021   -38.639 1.00 53.08  ? 200 LYS H O    1 
ATOM   2561 C  CB   . LYS B 2 185 ? 8.769   -3.234  -38.685 1.00 78.22  ? 200 LYS H CB   1 
ATOM   2562 C  CG   . LYS B 2 185 ? 10.050  -3.699  -39.362 1.00 69.80  ? 200 LYS H CG   1 
ATOM   2563 C  CD   . LYS B 2 185 ? 11.099  -4.065  -38.349 1.00 68.92  ? 200 LYS H CD   1 
ATOM   2564 C  CE   . LYS B 2 185 ? 12.382  -3.294  -38.525 1.00 54.89  ? 200 LYS H CE   1 
ATOM   2565 N  NZ   . LYS B 2 185 ? 13.104  -3.267  -37.241 1.00 47.51  ? 200 LYS H NZ   1 
ATOM   2566 N  N    . ASP B 2 186 ? 10.067  -3.856  -42.110 1.00 27.38  ? 201 ASP H N    1 
ATOM   2567 C  CA   . ASP B 2 186 ? 9.637   -5.089  -42.841 1.00 26.25  ? 201 ASP H CA   1 
ATOM   2568 C  C    . ASP B 2 186 ? 10.174  -5.233  -44.269 1.00 23.85  ? 201 ASP H C    1 
ATOM   2569 O  O    . ASP B 2 186 ? 10.981  -4.429  -44.730 1.00 25.43  ? 201 ASP H O    1 
ATOM   2570 C  CB   . ASP B 2 186 ? 8.121   -5.251  -42.739 1.00 29.37  ? 201 ASP H CB   1 
ATOM   2571 C  CG   . ASP B 2 186 ? 7.243   -5.454  -43.964 1.00 25.06  ? 201 ASP H CG   1 
ATOM   2572 O  OD1  . ASP B 2 186 ? 6.877   -6.570  -44.280 1.00 19.80  ? 201 ASP H OD1  1 
ATOM   2573 O  OD2  . ASP B 2 186 ? 6.729   -4.489  -44.407 1.00 31.27  ? 201 ASP H OD2  1 
ATOM   2574 N  N    . SER B 2 187 ? 9.820   -6.360  -44.912 1.00 19.58  ? 202 SER H N    1 
ATOM   2575 C  CA   . SER B 2 187 ? 10.183  -6.619  -46.298 1.00 19.20  ? 202 SER H CA   1 
ATOM   2576 C  C    . SER B 2 187 ? 9.196   -5.929  -47.236 1.00 19.63  ? 202 SER H C    1 
ATOM   2577 O  O    . SER B 2 187 ? 8.213   -5.346  -46.797 1.00 18.97  ? 202 SER H O    1 
ATOM   2578 C  CB   . SER B 2 187 ? 10.361  -8.109  -46.625 1.00 18.78  ? 202 SER H CB   1 
ATOM   2579 O  OG   . SER B 2 187 ? 9.169   -8.872  -46.493 1.00 17.13  ? 202 SER H OG   1 
ATOM   2580 N  N    . CYS B 2 188 ? 9.488   -5.935  -48.541 1.00 19.06  ? 203 CYS H N    1 
ATOM   2581 C  CA   . CYS B 2 188 ? 8.824   -4.989  -49.415 1.00 20.60  ? 203 CYS H CA   1 
ATOM   2582 C  C    . CYS B 2 188 ? 8.829   -5.478  -50.864 1.00 21.90  ? 203 CYS H C    1 
ATOM   2583 O  O    . CYS B 2 188 ? 9.345   -6.558  -51.171 1.00 21.54  ? 203 CYS H O    1 
ATOM   2584 C  CB   . CYS B 2 188 ? 9.474   -3.621  -49.233 1.00 20.95  ? 203 CYS H CB   1 
ATOM   2585 S  SG   . CYS B 2 188 ? 8.462   -2.219  -49.788 1.00 23.92  ? 203 CYS H SG   1 
ATOM   2586 N  N    . LYS B 2 189 ? 8.257   -4.655  -51.757 1.00 24.41  ? 204 LYS H N    1 
ATOM   2587 C  CA   . LYS B 2 189 ? 8.198   -4.963  -53.189 1.00 25.36  ? 204 LYS H CA   1 
ATOM   2588 C  C    . LYS B 2 189 ? 9.622   -5.103  -53.746 1.00 21.74  ? 204 LYS H C    1 
ATOM   2589 O  O    . LYS B 2 189 ? 10.510  -4.321  -53.443 1.00 19.13  ? 204 LYS H O    1 
ATOM   2590 C  CB   . LYS B 2 189 ? 7.432   -3.912  -54.009 1.00 29.77  ? 204 LYS H CB   1 
ATOM   2591 C  CG   . LYS B 2 189 ? 6.363   -3.112  -53.273 1.00 39.21  ? 204 LYS H CG   1 
ATOM   2592 C  CD   . LYS B 2 189 ? 5.079   -2.786  -54.043 1.00 47.69  ? 204 LYS H CD   1 
ATOM   2593 C  CE   . LYS B 2 189 ? 3.978   -2.223  -53.153 1.00 53.74  ? 204 LYS H CE   1 
ATOM   2594 N  NZ   . LYS B 2 189 ? 3.644   -3.142  -52.029 1.00 61.52  ? 204 LYS H NZ   1 
ATOM   2595 N  N    . GLY B 2 190 ? 9.839   -6.115  -54.582 1.00 21.01  ? 205 GLY H N    1 
ATOM   2596 C  CA   . GLY B 2 190 ? 11.152  -6.384  -55.134 1.00 20.63  ? 205 GLY H CA   1 
ATOM   2597 C  C    . GLY B 2 190 ? 11.941  -7.410  -54.308 1.00 20.09  ? 205 GLY H C    1 
ATOM   2598 O  O    . GLY B 2 190 ? 12.954  -7.915  -54.781 1.00 18.12  ? 205 GLY H O    1 
ATOM   2599 N  N    . ASP B 2 191 ? 11.482  -7.723  -53.085 1.00 19.27  ? 206 ASP H N    1 
ATOM   2600 C  CA   . ASP B 2 191 ? 12.102  -8.757  -52.273 1.00 17.30  ? 206 ASP H CA   1 
ATOM   2601 C  C    . ASP B 2 191 ? 11.456  -10.110 -52.542 1.00 16.94  ? 206 ASP H C    1 
ATOM   2602 O  O    . ASP B 2 191 ? 11.920  -11.137 -52.048 1.00 15.85  ? 206 ASP H O    1 
ATOM   2603 C  CB   . ASP B 2 191 ? 12.005  -8.404  -50.795 1.00 17.15  ? 206 ASP H CB   1 
ATOM   2604 C  CG   . ASP B 2 191 ? 12.835  -7.200  -50.402 1.00 16.59  ? 206 ASP H CG   1 
ATOM   2605 O  OD1  . ASP B 2 191 ? 13.969  -7.032  -50.963 1.00 16.11  ? 206 ASP H OD1  1 
ATOM   2606 O  OD2  . ASP B 2 191 ? 12.375  -6.484  -49.524 1.00 15.02  ? 206 ASP H OD2  1 
ATOM   2607 N  N    . SER B 2 192 ? 10.380  -10.096 -53.336 1.00 17.24  ? 207 SER H N    1 
ATOM   2608 C  CA   . SER B 2 192 ? 9.535   -11.264 -53.517 1.00 16.54  ? 207 SER H CA   1 
ATOM   2609 C  C    . SER B 2 192 ? 10.369  -12.430 -54.056 1.00 15.92  ? 207 SER H C    1 
ATOM   2610 O  O    . SER B 2 192 ? 11.332  -12.191 -54.781 1.00 17.54  ? 207 SER H O    1 
ATOM   2611 C  CB   . SER B 2 192 ? 8.349   -10.936 -54.409 1.00 16.97  ? 207 SER H CB   1 
ATOM   2612 O  OG   . SER B 2 192 ? 7.334   -10.227 -53.699 1.00 16.85  ? 207 SER H OG   1 
ATOM   2613 N  N    . GLY B 2 193 ? 10.023  -13.660 -53.645 1.00 13.35  ? 208 GLY H N    1 
ATOM   2614 C  CA   . GLY B 2 193 ? 10.723  -14.855 -54.058 1.00 13.50  ? 208 GLY H CA   1 
ATOM   2615 C  C    . GLY B 2 193 ? 11.915  -15.199 -53.169 1.00 13.69  ? 208 GLY H C    1 
ATOM   2616 O  O    . GLY B 2 193 ? 12.403  -16.320 -53.215 1.00 12.65  ? 208 GLY H O    1 
ATOM   2617 N  N    . GLY B 2 194 ? 12.346  -14.213 -52.364 1.00 14.46  ? 209 GLY H N    1 
ATOM   2618 C  CA   . GLY B 2 194 ? 13.516  -14.284 -51.502 1.00 14.44  ? 209 GLY H CA   1 
ATOM   2619 C  C    . GLY B 2 194 ? 13.252  -15.061 -50.212 1.00 13.54  ? 209 GLY H C    1 
ATOM   2620 O  O    . GLY B 2 194 ? 12.110  -15.385 -49.902 1.00 11.72  ? 209 GLY H O    1 
ATOM   2621 N  N    . PRO B 2 195 ? 14.334  -15.467 -49.511 1.00 14.73  ? 210 PRO H N    1 
ATOM   2622 C  CA   . PRO B 2 195 ? 14.242  -16.364 -48.367 1.00 14.83  ? 210 PRO H CA   1 
ATOM   2623 C  C    . PRO B 2 195 ? 13.813  -15.722 -47.057 1.00 15.76  ? 210 PRO H C    1 
ATOM   2624 O  O    . PRO B 2 195 ? 14.108  -14.554 -46.797 1.00 15.62  ? 210 PRO H O    1 
ATOM   2625 C  CB   . PRO B 2 195 ? 15.680  -16.887 -48.161 1.00 15.18  ? 210 PRO H CB   1 
ATOM   2626 C  CG   . PRO B 2 195 ? 16.593  -15.981 -48.941 1.00 14.69  ? 210 PRO H CG   1 
ATOM   2627 C  CD   . PRO B 2 195 ? 15.734  -15.199 -49.898 1.00 15.22  ? 210 PRO H CD   1 
ATOM   2628 N  N    . HIS B 2 196 ? 13.110  -16.539 -46.263 1.00 14.73  ? 211 HIS H N    1 
ATOM   2629 C  CA   . HIS B 2 196 ? 12.949  -16.371 -44.830 1.00 12.88  ? 211 HIS H CA   1 
ATOM   2630 C  C    . HIS B 2 196 ? 13.672  -17.585 -44.274 1.00 12.69  ? 211 HIS H C    1 
ATOM   2631 O  O    . HIS B 2 196 ? 13.256  -18.691 -44.566 1.00 12.37  ? 211 HIS H O    1 
ATOM   2632 C  CB   . HIS B 2 196 ? 11.449  -16.320 -44.469 1.00 11.40  ? 211 HIS H CB   1 
ATOM   2633 C  CG   . HIS B 2 196 ? 11.041  -16.435 -43.032 1.00 9.74   ? 211 HIS H CG   1 
ATOM   2634 N  ND1  . HIS B 2 196 ? 11.049  -17.626 -42.335 1.00 9.13   ? 211 HIS H ND1  1 
ATOM   2635 C  CD2  . HIS B 2 196 ? 10.524  -15.487 -42.175 1.00 8.68   ? 211 HIS H CD2  1 
ATOM   2636 C  CE1  . HIS B 2 196 ? 10.604  -17.390 -41.103 1.00 8.85   ? 211 HIS H CE1  1 
ATOM   2637 N  NE2  . HIS B 2 196 ? 10.265  -16.099 -40.994 1.00 8.36   ? 211 HIS H NE2  1 
ATOM   2638 N  N    . ALA B 2 197 ? 14.785  -17.341 -43.584 1.00 13.95  ? 212 ALA H N    1 
ATOM   2639 C  CA   . ALA B 2 197 ? 15.763  -18.344 -43.170 1.00 13.41  ? 212 ALA H CA   1 
ATOM   2640 C  C    . ALA B 2 197 ? 15.801  -18.413 -41.651 1.00 13.04  ? 212 ALA H C    1 
ATOM   2641 O  O    . ALA B 2 197 ? 15.885  -17.379 -40.999 1.00 12.21  ? 212 ALA H O    1 
ATOM   2642 C  CB   . ALA B 2 197 ? 17.142  -17.997 -43.686 1.00 12.85  ? 212 ALA H CB   1 
ATOM   2643 N  N    . THR B 2 198 ? 15.816  -19.639 -41.123 1.00 13.25  ? 213 THR H N    1 
ATOM   2644 C  CA   . THR B 2 198 ? 15.730  -19.877 -39.702 1.00 13.50  ? 213 THR H CA   1 
ATOM   2645 C  C    . THR B 2 198 ? 17.009  -20.589 -39.267 1.00 15.13  ? 213 THR H C    1 
ATOM   2646 O  O    . THR B 2 198 ? 17.451  -21.552 -39.905 1.00 15.55  ? 213 THR H O    1 
ATOM   2647 C  CB   . THR B 2 198 ? 14.428  -20.632 -39.416 1.00 13.69  ? 213 THR H CB   1 
ATOM   2648 O  OG1  . THR B 2 198 ? 13.367  -19.910 -40.032 1.00 12.56  ? 213 THR H OG1  1 
ATOM   2649 C  CG2  . THR B 2 198 ? 14.126  -20.806 -37.942 1.00 13.84  ? 213 THR H CG2  1 
ATOM   2650 N  N    . HIS B 2 199 ? 17.617  -20.063 -38.196 1.00 16.20  ? 214 HIS H N    1 
ATOM   2651 C  CA   . HIS B 2 199 ? 18.764  -20.670 -37.543 1.00 17.31  ? 214 HIS H CA   1 
ATOM   2652 C  C    . HIS B 2 199 ? 18.312  -21.669 -36.483 1.00 17.03  ? 214 HIS H C    1 
ATOM   2653 O  O    . HIS B 2 199 ? 17.426  -21.387 -35.672 1.00 19.27  ? 214 HIS H O    1 
ATOM   2654 C  CB   . HIS B 2 199 ? 19.556  -19.612 -36.766 1.00 18.87  ? 214 HIS H CB   1 
ATOM   2655 C  CG   . HIS B 2 199 ? 21.009  -19.863 -36.713 1.00 22.08  ? 214 HIS H CG   1 
ATOM   2656 N  ND1  . HIS B 2 199 ? 21.863  -19.123 -35.926 1.00 24.33  ? 214 HIS H ND1  1 
ATOM   2657 C  CD2  . HIS B 2 199 ? 21.777  -20.736 -37.398 1.00 23.59  ? 214 HIS H CD2  1 
ATOM   2658 C  CE1  . HIS B 2 199 ? 23.098  -19.561 -36.110 1.00 24.03  ? 214 HIS H CE1  1 
ATOM   2659 N  NE2  . HIS B 2 199 ? 23.067  -20.540 -36.991 1.00 24.73  ? 214 HIS H NE2  1 
ATOM   2660 N  N    . TYR B 2 200 ? 18.964  -22.826 -36.430 1.00 16.77  ? 215 TYR H N    1 
ATOM   2661 C  CA   . TYR B 2 200 ? 18.728  -23.738 -35.326 1.00 15.38  ? 215 TYR H CA   1 
ATOM   2662 C  C    . TYR B 2 200 ? 19.946  -24.629 -35.138 1.00 14.71  ? 215 TYR H C    1 
ATOM   2663 O  O    . TYR B 2 200 ? 20.334  -25.392 -36.028 1.00 12.51  ? 215 TYR H O    1 
ATOM   2664 C  CB   . TYR B 2 200 ? 17.451  -24.550 -35.561 1.00 16.35  ? 215 TYR H CB   1 
ATOM   2665 C  CG   . TYR B 2 200 ? 17.080  -25.474 -34.415 1.00 16.83  ? 215 TYR H CG   1 
ATOM   2666 C  CD1  . TYR B 2 200 ? 16.396  -24.999 -33.303 1.00 16.83  ? 215 TYR H CD1  1 
ATOM   2667 C  CD2  . TYR B 2 200 ? 17.423  -26.821 -34.453 1.00 18.59  ? 215 TYR H CD2  1 
ATOM   2668 C  CE1  . TYR B 2 200 ? 16.026  -25.854 -32.282 1.00 17.74  ? 215 TYR H CE1  1 
ATOM   2669 C  CE2  . TYR B 2 200 ? 17.080  -27.686 -33.429 1.00 18.84  ? 215 TYR H CE2  1 
ATOM   2670 C  CZ   . TYR B 2 200 ? 16.368  -27.198 -32.351 1.00 18.86  ? 215 TYR H CZ   1 
ATOM   2671 O  OH   . TYR B 2 200 ? 16.094  -28.035 -31.327 1.00 20.01  ? 215 TYR H OH   1 
ATOM   2672 N  N    . ARG B 2 201 ? 20.510  -24.500 -33.930 1.00 15.86  ? 216 ARG H N    1 
ATOM   2673 C  CA   . ARG B 2 201 ? 21.601  -25.324 -33.448 1.00 15.22  ? 216 ARG H CA   1 
ATOM   2674 C  C    . ARG B 2 201 ? 22.642  -25.405 -34.532 1.00 15.07  ? 216 ARG H C    1 
ATOM   2675 O  O    . ARG B 2 201 ? 23.094  -26.496 -34.873 1.00 16.19  ? 216 ARG H O    1 
ATOM   2676 C  CB   . ARG B 2 201 ? 21.120  -26.709 -33.014 1.00 15.29  ? 216 ARG H CB   1 
ATOM   2677 C  CG   . ARG B 2 201 ? 20.331  -26.648 -31.713 1.00 16.14  ? 216 ARG H CG   1 
ATOM   2678 C  CD   . ARG B 2 201 ? 19.833  -27.977 -31.169 1.00 17.49  ? 216 ARG H CD   1 
ATOM   2679 N  NE   . ARG B 2 201 ? 19.329  -27.780 -29.827 1.00 18.72  ? 216 ARG H NE   1 
ATOM   2680 C  CZ   . ARG B 2 201 ? 18.418  -28.537 -29.227 1.00 19.91  ? 216 ARG H CZ   1 
ATOM   2681 N  NH1  . ARG B 2 201 ? 18.024  -29.677 -29.767 1.00 21.44  ? 216 ARG H NH1  1 
ATOM   2682 N  NH2  . ARG B 2 201 ? 17.918  -28.144 -28.070 1.00 19.21  ? 216 ARG H NH2  1 
ATOM   2683 N  N    . GLY B 2 202 ? 22.986  -24.237 -35.060 1.00 15.46  ? 217 GLY H N    1 
ATOM   2684 C  CA   . GLY B 2 202 ? 24.173  -24.130 -35.888 1.00 17.33  ? 217 GLY H CA   1 
ATOM   2685 C  C    . GLY B 2 202 ? 23.917  -24.251 -37.389 1.00 18.10  ? 217 GLY H C    1 
ATOM   2686 O  O    . GLY B 2 202 ? 24.848  -24.092 -38.153 1.00 22.40  ? 217 GLY H O    1 
ATOM   2687 N  N    . THR B 2 203 ? 22.686  -24.495 -37.835 1.00 17.18  ? 218 THR H N    1 
ATOM   2688 C  CA   . THR B 2 203 ? 22.438  -24.611 -39.267 1.00 16.91  ? 218 THR H CA   1 
ATOM   2689 C  C    . THR B 2 203 ? 21.216  -23.771 -39.644 1.00 15.81  ? 218 THR H C    1 
ATOM   2690 O  O    . THR B 2 203 ? 20.345  -23.556 -38.798 1.00 15.07  ? 218 THR H O    1 
ATOM   2691 C  CB   . THR B 2 203 ? 22.292  -26.088 -39.614 1.00 18.49  ? 218 THR H CB   1 
ATOM   2692 O  OG1  . THR B 2 203 ? 23.525  -26.651 -39.158 1.00 19.32  ? 218 THR H OG1  1 
ATOM   2693 C  CG2  . THR B 2 203 ? 22.025  -26.375 -41.076 1.00 18.13  ? 218 THR H CG2  1 
ATOM   2694 N  N    . TRP B 2 204 ? 21.192  -23.303 -40.906 1.00 15.28  ? 219 TRP H N    1 
ATOM   2695 C  CA   . TRP B 2 204 ? 20.155  -22.433 -41.449 1.00 14.98  ? 219 TRP H CA   1 
ATOM   2696 C  C    . TRP B 2 204 ? 19.225  -23.190 -42.401 1.00 15.43  ? 219 TRP H C    1 
ATOM   2697 O  O    . TRP B 2 204 ? 19.703  -23.909 -43.286 1.00 14.01  ? 219 TRP H O    1 
ATOM   2698 C  CB   . TRP B 2 204 ? 20.784  -21.237 -42.165 1.00 14.87  ? 219 TRP H CB   1 
ATOM   2699 C  CG   . TRP B 2 204 ? 21.496  -20.278 -41.248 1.00 16.20  ? 219 TRP H CG   1 
ATOM   2700 C  CD1  . TRP B 2 204 ? 22.769  -20.357 -40.769 1.00 16.89  ? 219 TRP H CD1  1 
ATOM   2701 C  CD2  . TRP B 2 204 ? 20.932  -19.090 -40.659 1.00 17.56  ? 219 TRP H CD2  1 
ATOM   2702 N  NE1  . TRP B 2 204 ? 23.036  -19.291 -39.954 1.00 16.38  ? 219 TRP H NE1  1 
ATOM   2703 C  CE2  . TRP B 2 204 ? 21.931  -18.508 -39.850 1.00 17.28  ? 219 TRP H CE2  1 
ATOM   2704 C  CE3  . TRP B 2 204 ? 19.687  -18.467 -40.736 1.00 17.35  ? 219 TRP H CE3  1 
ATOM   2705 C  CZ2  . TRP B 2 204 ? 21.717  -17.344 -39.114 1.00 17.43  ? 219 TRP H CZ2  1 
ATOM   2706 C  CZ3  . TRP B 2 204 ? 19.473  -17.334 -39.990 1.00 18.26  ? 219 TRP H CZ3  1 
ATOM   2707 C  CH2  . TRP B 2 204 ? 20.478  -16.767 -39.211 1.00 17.13  ? 219 TRP H CH2  1 
ATOM   2708 N  N    . TYR B 2 205 ? 17.896  -22.983 -42.241 1.00 15.21  ? 220 TYR H N    1 
ATOM   2709 C  CA   . TYR B 2 205 ? 16.901  -23.683 -43.050 1.00 14.97  ? 220 TYR H CA   1 
ATOM   2710 C  C    . TYR B 2 205 ? 15.966  -22.712 -43.767 1.00 14.58  ? 220 TYR H C    1 
ATOM   2711 O  O    . TYR B 2 205 ? 15.699  -21.623 -43.286 1.00 14.92  ? 220 TYR H O    1 
ATOM   2712 C  CB   . TYR B 2 205 ? 16.111  -24.649 -42.167 1.00 15.08  ? 220 TYR H CB   1 
ATOM   2713 C  CG   . TYR B 2 205 ? 16.970  -25.698 -41.491 1.00 16.00  ? 220 TYR H CG   1 
ATOM   2714 C  CD1  . TYR B 2 205 ? 17.260  -26.931 -42.077 1.00 16.41  ? 220 TYR H CD1  1 
ATOM   2715 C  CD2  . TYR B 2 205 ? 17.541  -25.422 -40.264 1.00 16.70  ? 220 TYR H CD2  1 
ATOM   2716 C  CE1  . TYR B 2 205 ? 18.056  -27.873 -41.435 1.00 15.61  ? 220 TYR H CE1  1 
ATOM   2717 C  CE2  . TYR B 2 205 ? 18.322  -26.353 -39.612 1.00 16.51  ? 220 TYR H CE2  1 
ATOM   2718 C  CZ   . TYR B 2 205 ? 18.593  -27.567 -40.201 1.00 16.14  ? 220 TYR H CZ   1 
ATOM   2719 O  OH   . TYR B 2 205 ? 19.406  -28.369 -39.469 1.00 17.91  ? 220 TYR H OH   1 
ATOM   2720 N  N    . LEU B 2 206 ? 15.459  -23.094 -44.944 1.00 14.60  ? 221 LEU H N    1 
ATOM   2721 C  CA   . LEU B 2 206 ? 14.421  -22.288 -45.563 1.00 15.22  ? 221 LEU H CA   1 
ATOM   2722 C  C    . LEU B 2 206 ? 13.082  -22.640 -44.920 1.00 17.14  ? 221 LEU H C    1 
ATOM   2723 O  O    . LEU B 2 206 ? 12.664  -23.797 -44.969 1.00 19.68  ? 221 LEU H O    1 
ATOM   2724 C  CB   . LEU B 2 206 ? 14.370  -22.591 -47.053 1.00 16.08  ? 221 LEU H CB   1 
ATOM   2725 C  CG   . LEU B 2 206 ? 13.307  -21.831 -47.847 1.00 15.91  ? 221 LEU H CG   1 
ATOM   2726 C  CD1  . LEU B 2 206 ? 13.736  -20.386 -47.986 1.00 15.95  ? 221 LEU H CD1  1 
ATOM   2727 C  CD2  . LEU B 2 206 ? 13.074  -22.475 -49.223 1.00 15.51  ? 221 LEU H CD2  1 
ATOM   2728 N  N    . THR B 2 207 ? 12.444  -21.647 -44.301 1.00 15.74  ? 222 THR H N    1 
ATOM   2729 C  CA   . THR B 2 207 ? 11.126  -21.796 -43.737 1.00 15.51  ? 222 THR H CA   1 
ATOM   2730 C  C    . THR B 2 207 ? 10.102  -20.961 -44.494 1.00 14.61  ? 222 THR H C    1 
ATOM   2731 O  O    . THR B 2 207 ? 8.922   -21.182 -44.307 1.00 14.44  ? 222 THR H O    1 
ATOM   2732 C  CB   . THR B 2 207 ? 11.099  -21.377 -42.261 1.00 16.06  ? 222 THR H CB   1 
ATOM   2733 O  OG1  . THR B 2 207 ? 11.836  -20.155 -42.195 1.00 16.76  ? 222 THR H OG1  1 
ATOM   2734 C  CG2  . THR B 2 207 ? 11.674  -22.417 -41.320 1.00 16.00  ? 222 THR H CG2  1 
ATOM   2735 N  N    . GLY B 2 208 ? 10.518  -19.965 -45.274 1.00 15.29  ? 223 GLY H N    1 
ATOM   2736 C  CA   . GLY B 2 208 ? 9.541   -19.089 -45.910 1.00 16.13  ? 223 GLY H CA   1 
ATOM   2737 C  C    . GLY B 2 208 ? 10.000  -18.471 -47.236 1.00 16.35  ? 223 GLY H C    1 
ATOM   2738 O  O    . GLY B 2 208 ? 11.172  -18.558 -47.585 1.00 15.99  ? 223 GLY H O    1 
ATOM   2739 N  N    . ILE B 2 209 ? 9.052   -17.824 -47.948 1.00 16.22  ? 224 ILE H N    1 
ATOM   2740 C  CA   . ILE B 2 209 ? 9.348   -17.090 -49.171 1.00 16.12  ? 224 ILE H CA   1 
ATOM   2741 C  C    . ILE B 2 209 ? 8.667   -15.723 -49.098 1.00 17.03  ? 224 ILE H C    1 
ATOM   2742 O  O    . ILE B 2 209 ? 7.513   -15.629 -48.715 1.00 18.40  ? 224 ILE H O    1 
ATOM   2743 C  CB   . ILE B 2 209 ? 8.861   -17.874 -50.402 1.00 15.90  ? 224 ILE H CB   1 
ATOM   2744 C  CG1  . ILE B 2 209 ? 9.463   -19.276 -50.457 1.00 17.71  ? 224 ILE H CG1  1 
ATOM   2745 C  CG2  . ILE B 2 209 ? 9.147   -17.116 -51.678 1.00 15.36  ? 224 ILE H CG2  1 
ATOM   2746 C  CD1  . ILE B 2 209 ? 8.710   -20.225 -51.369 1.00 18.66  ? 224 ILE H CD1  1 
ATOM   2747 N  N    . VAL B 2 210 ? 9.365   -14.643 -49.459 1.00 16.25  ? 225 VAL H N    1 
ATOM   2748 C  CA   . VAL B 2 210 ? 8.692   -13.360 -49.472 1.00 16.67  ? 225 VAL H CA   1 
ATOM   2749 C  C    . VAL B 2 210 ? 7.565   -13.400 -50.510 1.00 17.06  ? 225 VAL H C    1 
ATOM   2750 O  O    . VAL B 2 210 ? 7.809   -13.633 -51.689 1.00 15.98  ? 225 VAL H O    1 
ATOM   2751 C  CB   . VAL B 2 210 ? 9.666   -12.209 -49.762 1.00 15.97  ? 225 VAL H CB   1 
ATOM   2752 C  CG1  . VAL B 2 210 ? 8.955   -10.864 -49.757 1.00 15.08  ? 225 VAL H CG1  1 
ATOM   2753 C  CG2  . VAL B 2 210 ? 10.824  -12.218 -48.788 1.00 15.63  ? 225 VAL H CG2  1 
ATOM   2754 N  N    . SER B 2 211 ? 6.334   -13.088 -50.085 1.00 16.26  ? 226 SER H N    1 
ATOM   2755 C  CA   . SER B 2 211 ? 5.198   -13.192 -50.983 1.00 15.95  ? 226 SER H CA   1 
ATOM   2756 C  C    . SER B 2 211 ? 4.431   -11.868 -51.126 1.00 15.33  ? 226 SER H C    1 
ATOM   2757 O  O    . SER B 2 211 ? 4.434   -11.270 -52.182 1.00 14.03  ? 226 SER H O    1 
ATOM   2758 C  CB   . SER B 2 211 ? 4.348   -14.328 -50.544 1.00 15.74  ? 226 SER H CB   1 
ATOM   2759 O  OG   . SER B 2 211 ? 3.319   -14.519 -51.471 1.00 16.05  ? 226 SER H OG   1 
ATOM   2760 N  N    . TRP B 2 212 ? 3.780   -11.371 -50.080 1.00 17.33  ? 227 TRP H N    1 
ATOM   2761 C  CA   . TRP B 2 212 ? 2.925   -10.204 -50.232 1.00 18.79  ? 227 TRP H CA   1 
ATOM   2762 C  C    . TRP B 2 212 ? 2.693   -9.513  -48.891 1.00 20.29  ? 227 TRP H C    1 
ATOM   2763 O  O    . TRP B 2 212 ? 3.084   -10.007 -47.845 1.00 20.33  ? 227 TRP H O    1 
ATOM   2764 C  CB   . TRP B 2 212 ? 1.596   -10.593 -50.894 1.00 18.45  ? 227 TRP H CB   1 
ATOM   2765 C  CG   . TRP B 2 212 ? 0.760   -11.562 -50.103 1.00 19.98  ? 227 TRP H CG   1 
ATOM   2766 C  CD1  . TRP B 2 212 ? 0.921   -12.915 -50.029 1.00 20.65  ? 227 TRP H CD1  1 
ATOM   2767 C  CD2  . TRP B 2 212 ? -0.345  -11.245 -49.219 1.00 21.66  ? 227 TRP H CD2  1 
ATOM   2768 N  NE1  . TRP B 2 212 ? -0.010  -13.469 -49.182 1.00 21.73  ? 227 TRP H NE1  1 
ATOM   2769 C  CE2  . TRP B 2 212 ? -0.790  -12.467 -48.659 1.00 21.09  ? 227 TRP H CE2  1 
ATOM   2770 C  CE3  . TRP B 2 212 ? -0.995  -10.059 -48.845 1.00 21.49  ? 227 TRP H CE3  1 
ATOM   2771 C  CZ2  . TRP B 2 212 ? -1.851  -12.528 -47.755 1.00 21.44  ? 227 TRP H CZ2  1 
ATOM   2772 C  CZ3  . TRP B 2 212 ? -2.043  -10.122 -47.948 1.00 22.09  ? 227 TRP H CZ3  1 
ATOM   2773 C  CH2  . TRP B 2 212 ? -2.457  -11.340 -47.396 1.00 22.13  ? 227 TRP H CH2  1 
ATOM   2774 N  N    . GLY B 2 213 ? 2.035   -8.358  -48.942 1.00 23.35  ? 228 GLY H N    1 
ATOM   2775 C  CA   . GLY B 2 213 ? 1.770   -7.555  -47.764 1.00 25.82  ? 228 GLY H CA   1 
ATOM   2776 C  C    . GLY B 2 213 ? 0.884   -6.358  -48.115 1.00 31.40  ? 228 GLY H C    1 
ATOM   2777 O  O    . GLY B 2 213 ? 0.830   -5.967  -49.268 1.00 34.72  ? 228 GLY H O    1 
ATOM   2778 N  N    . GLN B 2 214 ? 0.173   -5.811  -47.121 1.00 37.97  ? 229 GLN H N    1 
ATOM   2779 C  CA   . GLN B 2 214 ? -0.792  -4.741  -47.318 1.00 42.09  ? 229 GLN H CA   1 
ATOM   2780 C  C    . GLN B 2 214 ? -0.224  -3.488  -46.671 1.00 37.62  ? 229 GLN H C    1 
ATOM   2781 O  O    . GLN B 2 214 ? 0.916   -3.182  -47.036 1.00 33.74  ? 229 GLN H O    1 
ATOM   2782 C  CB   . GLN B 2 214 ? -2.147  -5.030  -46.665 1.00 53.81  ? 229 GLN H CB   1 
ATOM   2783 C  CG   . GLN B 2 214 ? -2.867  -6.248  -47.236 1.00 67.15  ? 229 GLN H CG   1 
ATOM   2784 C  CD   . GLN B 2 214 ? -3.485  -6.036  -48.605 1.00 80.92  ? 229 GLN H CD   1 
ATOM   2785 O  OE1  . GLN B 2 214 ? -3.255  -6.806  -49.540 1.00 87.02  ? 229 GLN H OE1  1 
ATOM   2786 N  NE2  . GLN B 2 214 ? -4.320  -5.013  -48.726 1.00 76.56  ? 229 GLN H NE2  1 
ATOM   2787 N  N    . GLY B 2 215 ? 1.020   -2.307  -48.376 1.00 25.71  ? 230 GLY H N    1 
ATOM   2788 C  CA   . GLY B 2 215 ? 2.310   -2.182  -49.057 1.00 26.25  ? 230 GLY H CA   1 
ATOM   2789 C  C    . GLY B 2 215 ? 3.444   -2.663  -48.162 1.00 26.22  ? 230 GLY H C    1 
ATOM   2790 O  O    . GLY B 2 215 ? 3.711   -3.852  -48.048 1.00 24.22  ? 230 GLY H O    1 
ATOM   2791 N  N    . CYS B 2 216 ? 4.118   -1.687  -47.571 1.00 25.62  ? 231 CYS H N    1 
ATOM   2792 C  CA   . CYS B 2 216 ? 5.259   -1.913  -46.725 1.00 24.13  ? 231 CYS H CA   1 
ATOM   2793 C  C    . CYS B 2 216 ? 5.105   -0.912  -45.582 1.00 24.34  ? 231 CYS H C    1 
ATOM   2794 O  O    . CYS B 2 216 ? 6.026   -0.127  -45.371 1.00 27.57  ? 231 CYS H O    1 
ATOM   2795 C  CB   . CYS B 2 216 ? 6.570   -1.739  -47.487 1.00 24.62  ? 231 CYS H CB   1 
ATOM   2796 S  SG   . CYS B 2 216 ? 6.582   -2.530  -49.116 1.00 25.00  ? 231 CYS H SG   1 
ATOM   2797 N  N    . ALA B 2 217 ? 6.099   -2.025  -44.320 1.00 32.49  ? 232 ALA H N    1 
ATOM   2798 C  CA   . ALA B 2 217 ? 6.020   -1.508  -42.944 1.00 34.09  ? 232 ALA H CA   1 
ATOM   2799 C  C    . ALA B 2 217 ? 4.686   -0.772  -42.768 1.00 36.38  ? 232 ALA H C    1 
ATOM   2800 O  O    . ALA B 2 217 ? 4.658   0.381   -42.396 1.00 30.19  ? 232 ALA H O    1 
ATOM   2801 C  CB   . ALA B 2 217 ? 7.246   -0.643  -42.761 1.00 33.44  ? 232 ALA H CB   1 
ATOM   2802 N  N    . THR B 2 218 ? 3.555   -1.425  -43.034 1.00 48.40  ? 233 THR H N    1 
ATOM   2803 C  CA   . THR B 2 218 ? 3.397   -2.882  -43.098 1.00 71.33  ? 233 THR H CA   1 
ATOM   2804 C  C    . THR B 2 218 ? 4.557   -3.632  -43.775 1.00 75.52  ? 233 THR H C    1 
ATOM   2805 O  O    . THR B 2 218 ? 4.758   -4.831  -43.441 1.00 69.50  ? 233 THR H O    1 
ATOM   2806 C  CB   . THR B 2 218 ? 2.087   -3.249  -43.818 1.00 79.64  ? 233 THR H CB   1 
ATOM   2807 O  OG1  . THR B 2 218 ? 2.319   -4.314  -44.754 1.00 56.23  ? 233 THR H OG1  1 
ATOM   2808 C  CG2  . THR B 2 218 ? 1.416   -2.048  -44.476 1.00 79.14  ? 233 THR H CG2  1 
ATOM   2809 N  N    . VAL B 2 219 ? 1.618   -0.490  -41.209 1.00 28.96  ? 234 VAL H N    1 
ATOM   2810 C  CA   . VAL B 2 219 ? 1.146   -0.067  -39.841 1.00 31.99  ? 234 VAL H CA   1 
ATOM   2811 C  C    . VAL B 2 219 ? -0.185  -0.707  -39.472 1.00 29.76  ? 234 VAL H C    1 
ATOM   2812 O  O    . VAL B 2 219 ? -1.211  -0.330  -40.011 1.00 29.69  ? 234 VAL H O    1 
ATOM   2813 C  CB   . VAL B 2 219 ? 0.949   1.448   -39.672 1.00 38.43  ? 234 VAL H CB   1 
ATOM   2814 C  CG1  . VAL B 2 219 ? -0.006  1.756   -38.530 1.00 36.17  ? 234 VAL H CG1  1 
ATOM   2815 C  CG2  . VAL B 2 219 ? 2.247   2.187   -39.420 1.00 47.42  ? 234 VAL H CG2  1 
ATOM   2816 N  N    . GLY B 2 220 ? -0.177  -1.580  -38.466 1.00 28.90  ? 235 GLY H N    1 
ATOM   2817 C  CA   . GLY B 2 220 ? -1.281  -2.504  -38.244 1.00 27.58  ? 235 GLY H CA   1 
ATOM   2818 C  C    . GLY B 2 220 ? -1.308  -3.682  -39.230 1.00 27.62  ? 235 GLY H C    1 
ATOM   2819 O  O    . GLY B 2 220 ? -2.292  -4.404  -39.275 1.00 26.77  ? 235 GLY H O    1 
ATOM   2820 N  N    . HIS B 2 221 ? -0.244  -3.896  -40.027 1.00 30.46  ? 236 HIS H N    1 
ATOM   2821 C  CA   . HIS B 2 221 ? -0.210  -4.997  -40.990 1.00 30.23  ? 236 HIS H CA   1 
ATOM   2822 C  C    . HIS B 2 221 ? 1.095   -5.781  -40.866 1.00 26.67  ? 236 HIS H C    1 
ATOM   2823 O  O    . HIS B 2 221 ? 2.089   -5.253  -40.426 1.00 27.86  ? 236 HIS H O    1 
ATOM   2824 C  CB   . HIS B 2 221 ? -0.443  -4.461  -42.406 1.00 30.56  ? 236 HIS H CB   1 
ATOM   2825 C  CG   . HIS B 2 221 ? -1.848  -4.018  -42.601 1.00 38.05  ? 236 HIS H CG   1 
ATOM   2826 N  ND1  . HIS B 2 221 ? -2.220  -2.691  -42.518 1.00 39.49  ? 236 HIS H ND1  1 
ATOM   2827 C  CD2  . HIS B 2 221 ? -2.978  -4.730  -42.762 1.00 38.98  ? 236 HIS H CD2  1 
ATOM   2828 C  CE1  . HIS B 2 221 ? -3.533  -2.613  -42.671 1.00 43.58  ? 236 HIS H CE1  1 
ATOM   2829 N  NE2  . HIS B 2 221 ? -4.013  -3.845  -42.808 1.00 42.35  ? 236 HIS H NE2  1 
ATOM   2830 N  N    . PHE B 2 222 ? 1.095   -7.045  -41.278 1.00 25.09  ? 237 PHE H N    1 
ATOM   2831 C  CA   . PHE B 2 222 ? 2.293   -7.858  -41.240 1.00 22.85  ? 237 PHE H CA   1 
ATOM   2832 C  C    . PHE B 2 222 ? 2.692   -8.329  -42.643 1.00 23.17  ? 237 PHE H C    1 
ATOM   2833 O  O    . PHE B 2 222 ? 1.892   -8.360  -43.574 1.00 26.85  ? 237 PHE H O    1 
ATOM   2834 C  CB   . PHE B 2 222 ? 2.080   -9.038  -40.298 1.00 21.91  ? 237 PHE H CB   1 
ATOM   2835 C  CG   . PHE B 2 222 ? 1.830   -8.678  -38.857 1.00 22.41  ? 237 PHE H CG   1 
ATOM   2836 C  CD1  . PHE B 2 222 ? 2.864   -8.603  -37.929 1.00 20.72  ? 237 PHE H CD1  1 
ATOM   2837 C  CD2  . PHE B 2 222 ? 0.528   -8.497  -38.419 1.00 23.06  ? 237 PHE H CD2  1 
ATOM   2838 C  CE1  . PHE B 2 222 ? 2.592   -8.322  -36.599 1.00 21.31  ? 237 PHE H CE1  1 
ATOM   2839 C  CE2  . PHE B 2 222 ? 0.258   -8.217  -37.090 1.00 23.69  ? 237 PHE H CE2  1 
ATOM   2840 C  CZ   . PHE B 2 222 ? 1.295   -8.130  -36.181 1.00 23.22  ? 237 PHE H CZ   1 
ATOM   2841 N  N    . GLY B 2 223 ? 3.974   -8.651  -42.806 1.00 19.24  ? 238 GLY H N    1 
ATOM   2842 C  CA   . GLY B 2 223 ? 4.424   -9.376  -43.970 1.00 18.56  ? 238 GLY H CA   1 
ATOM   2843 C  C    . GLY B 2 223 ? 3.820   -10.771 -43.991 1.00 17.78  ? 238 GLY H C    1 
ATOM   2844 O  O    . GLY B 2 223 ? 3.549   -11.343 -42.943 1.00 18.87  ? 238 GLY H O    1 
ATOM   2845 N  N    . VAL B 2 224 ? 3.597   -11.297 -45.191 1.00 17.22  ? 239 VAL H N    1 
ATOM   2846 C  CA   . VAL B 2 224 ? 3.049   -12.634 -45.348 1.00 19.32  ? 239 VAL H CA   1 
ATOM   2847 C  C    . VAL B 2 224 ? 4.022   -13.408 -46.229 1.00 17.89  ? 239 VAL H C    1 
ATOM   2848 O  O    . VAL B 2 224 ? 4.462   -12.887 -47.248 1.00 17.58  ? 239 VAL H O    1 
ATOM   2849 C  CB   . VAL B 2 224 ? 1.600   -12.622 -45.916 1.00 20.33  ? 239 VAL H CB   1 
ATOM   2850 C  CG1  . VAL B 2 224 ? 0.964   -13.996 -45.900 1.00 21.32  ? 239 VAL H CG1  1 
ATOM   2851 C  CG2  . VAL B 2 224 ? 0.688   -11.666 -45.167 1.00 19.99  ? 239 VAL H CG2  1 
ATOM   2852 N  N    . TYR B 2 225 ? 4.328   -14.646 -45.808 1.00 18.50  ? 240 TYR H N    1 
ATOM   2853 C  CA   . TYR B 2 225 ? 5.340   -15.506 -46.417 1.00 16.94  ? 240 TYR H CA   1 
ATOM   2854 C  C    . TYR B 2 225 ? 4.697   -16.841 -46.784 1.00 16.78  ? 240 TYR H C    1 
ATOM   2855 O  O    . TYR B 2 225 ? 3.805   -17.321 -46.099 1.00 17.08  ? 240 TYR H O    1 
ATOM   2856 C  CB   . TYR B 2 225 ? 6.475   -15.716 -45.405 1.00 17.29  ? 240 TYR H CB   1 
ATOM   2857 C  CG   . TYR B 2 225 ? 7.151   -14.401 -45.038 1.00 17.26  ? 240 TYR H CG   1 
ATOM   2858 C  CD1  . TYR B 2 225 ? 8.275   -13.969 -45.743 1.00 16.04  ? 240 TYR H CD1  1 
ATOM   2859 C  CD2  . TYR B 2 225 ? 6.602   -13.538 -44.092 1.00 15.36  ? 240 TYR H CD2  1 
ATOM   2860 C  CE1  . TYR B 2 225 ? 8.841   -12.736 -45.489 1.00 15.92  ? 240 TYR H CE1  1 
ATOM   2861 C  CE2  . TYR B 2 225 ? 7.172   -12.304 -43.841 1.00 14.83  ? 240 TYR H CE2  1 
ATOM   2862 C  CZ   . TYR B 2 225 ? 8.306   -11.910 -44.521 1.00 15.80  ? 240 TYR H CZ   1 
ATOM   2863 O  OH   . TYR B 2 225 ? 8.918   -10.708 -44.289 1.00 17.77  ? 240 TYR H OH   1 
ATOM   2864 N  N    . THR B 2 226 ? 5.150   -17.442 -47.877 1.00 16.33  ? 241 THR H N    1 
ATOM   2865 C  CA   . THR B 2 226 ? 4.759   -18.789 -48.226 1.00 15.11  ? 241 THR H CA   1 
ATOM   2866 C  C    . THR B 2 226 ? 5.274   -19.717 -47.151 1.00 16.32  ? 241 THR H C    1 
ATOM   2867 O  O    . THR B 2 226 ? 6.414   -19.593 -46.745 1.00 17.82  ? 241 THR H O    1 
ATOM   2868 C  CB   . THR B 2 226 ? 5.266   -19.181 -49.613 1.00 13.96  ? 241 THR H CB   1 
ATOM   2869 O  OG1  . THR B 2 226 ? 4.928   -18.141 -50.525 1.00 12.40  ? 241 THR H OG1  1 
ATOM   2870 C  CG2  . THR B 2 226 ? 4.641   -20.463 -50.089 1.00 13.83  ? 241 THR H CG2  1 
ATOM   2871 N  N    . ARG B 2 227 ? 4.392   -20.599 -46.672 1.00 17.74  ? 242 ARG H N    1 
ATOM   2872 C  CA   . ARG B 2 227 ? 4.716   -21.581 -45.652 1.00 17.40  ? 242 ARG H CA   1 
ATOM   2873 C  C    . ARG B 2 227 ? 5.340   -22.777 -46.356 1.00 17.19  ? 242 ARG H C    1 
ATOM   2874 O  O    . ARG B 2 227 ? 4.624   -23.722 -46.719 1.00 16.23  ? 242 ARG H O    1 
ATOM   2875 C  CB   . ARG B 2 227 ? 3.469   -22.005 -44.864 1.00 19.51  ? 242 ARG H CB   1 
ATOM   2876 C  CG   . ARG B 2 227 ? 3.762   -22.846 -43.628 1.00 21.96  ? 242 ARG H CG   1 
ATOM   2877 C  CD   . ARG B 2 227 ? 2.550   -23.344 -42.859 1.00 25.33  ? 242 ARG H CD   1 
ATOM   2878 N  NE   . ARG B 2 227 ? 1.690   -22.269 -42.349 1.00 29.81  ? 242 ARG H NE   1 
ATOM   2879 C  CZ   . ARG B 2 227 ? 1.625   -21.842 -41.085 1.00 30.29  ? 242 ARG H CZ   1 
ATOM   2880 N  NH1  . ARG B 2 227 ? 2.368   -22.390 -40.142 1.00 29.75  ? 242 ARG H NH1  1 
ATOM   2881 N  NH2  . ARG B 2 227 ? 0.823   -20.839 -40.765 1.00 30.51  ? 242 ARG H NH2  1 
ATOM   2882 N  N    . VAL B 2 228 ? 6.676   -22.710 -46.523 1.00 16.04  ? 243 VAL H N    1 
ATOM   2883 C  CA   . VAL B 2 228 ? 7.426   -23.715 -47.272 1.00 15.75  ? 243 VAL H CA   1 
ATOM   2884 C  C    . VAL B 2 228 ? 7.157   -25.136 -46.785 1.00 15.44  ? 243 VAL H C    1 
ATOM   2885 O  O    . VAL B 2 228 ? 7.170   -26.056 -47.600 1.00 15.86  ? 243 VAL H O    1 
ATOM   2886 C  CB   . VAL B 2 228 ? 8.935   -23.414 -47.279 1.00 15.10  ? 243 VAL H CB   1 
ATOM   2887 C  CG1  . VAL B 2 228 ? 9.777   -24.598 -47.710 1.00 14.97  ? 243 VAL H CG1  1 
ATOM   2888 C  CG2  . VAL B 2 228 ? 9.225   -22.231 -48.171 1.00 15.09  ? 243 VAL H CG2  1 
ATOM   2889 N  N    . SER B 2 229 ? 6.924   -25.321 -45.484 1.00 16.16  ? 244 SER H N    1 
ATOM   2890 C  CA   . SER B 2 229 ? 6.777   -26.645 -44.902 1.00 16.52  ? 244 SER H CA   1 
ATOM   2891 C  C    . SER B 2 229 ? 5.683   -27.463 -45.591 1.00 16.49  ? 244 SER H C    1 
ATOM   2892 O  O    . SER B 2 229 ? 5.733   -28.684 -45.554 1.00 16.36  ? 244 SER H O    1 
ATOM   2893 C  CB   . SER B 2 229 ? 6.471   -26.553 -43.445 1.00 16.65  ? 244 SER H CB   1 
ATOM   2894 O  OG   . SER B 2 229 ? 5.193   -25.976 -43.307 1.00 18.60  ? 244 SER H OG   1 
ATOM   2895 N  N    . GLN B 2 230 ? 4.673   -26.790 -46.155 1.00 17.48  ? 245 GLN H N    1 
ATOM   2896 C  CA   . GLN B 2 230 ? 3.567   -27.448 -46.831 1.00 17.24  ? 245 GLN H CA   1 
ATOM   2897 C  C    . GLN B 2 230 ? 3.979   -28.018 -48.182 1.00 16.23  ? 245 GLN H C    1 
ATOM   2898 O  O    . GLN B 2 230 ? 3.206   -28.761 -48.757 1.00 16.64  ? 245 GLN H O    1 
ATOM   2899 C  CB   . GLN B 2 230 ? 2.423   -26.472 -47.076 1.00 17.88  ? 245 GLN H CB   1 
ATOM   2900 C  CG   . GLN B 2 230 ? 1.870   -25.879 -45.809 1.00 21.75  ? 245 GLN H CG   1 
ATOM   2901 C  CD   . GLN B 2 230 ? 1.108   -26.883 -44.980 1.00 26.52  ? 245 GLN H CD   1 
ATOM   2902 O  OE1  . GLN B 2 230 ? 1.577   -27.296 -43.931 1.00 32.26  ? 245 GLN H OE1  1 
ATOM   2903 N  NE2  . GLN B 2 230 ? -0.062  -27.294 -45.441 1.00 29.58  ? 245 GLN H NE2  1 
ATOM   2904 N  N    . TYR B 2 231 ? 5.124   -27.615 -48.736 1.00 16.01  ? 246 TYR H N    1 
ATOM   2905 C  CA   . TYR B 2 231 ? 5.435   -27.940 -50.118 1.00 16.03  ? 246 TYR H CA   1 
ATOM   2906 C  C    . TYR B 2 231 ? 6.650   -28.859 -50.204 1.00 17.36  ? 246 TYR H C    1 
ATOM   2907 O  O    . TYR B 2 231 ? 7.141   -29.120 -51.290 1.00 19.92  ? 246 TYR H O    1 
ATOM   2908 C  CB   . TYR B 2 231 ? 5.689   -26.667 -50.925 1.00 16.67  ? 246 TYR H CB   1 
ATOM   2909 C  CG   . TYR B 2 231 ? 4.495   -25.727 -51.006 1.00 16.88  ? 246 TYR H CG   1 
ATOM   2910 C  CD1  . TYR B 2 231 ? 3.495   -25.925 -51.945 1.00 17.52  ? 246 TYR H CD1  1 
ATOM   2911 C  CD2  . TYR B 2 231 ? 4.333   -24.696 -50.098 1.00 16.68  ? 246 TYR H CD2  1 
ATOM   2912 C  CE1  . TYR B 2 231 ? 2.380   -25.110 -52.005 1.00 16.88  ? 246 TYR H CE1  1 
ATOM   2913 C  CE2  . TYR B 2 231 ? 3.227   -23.870 -50.143 1.00 17.61  ? 246 TYR H CE2  1 
ATOM   2914 C  CZ   . TYR B 2 231 ? 2.257   -24.069 -51.112 1.00 18.33  ? 246 TYR H CZ   1 
ATOM   2915 O  OH   . TYR B 2 231 ? 1.156   -23.274 -51.160 1.00 18.83  ? 246 TYR H OH   1 
ATOM   2916 N  N    . ILE B 2 232 ? 7.123   -29.394 -49.079 1.00 18.92  ? 247 ILE H N    1 
ATOM   2917 C  CA   . ILE B 2 232 ? 8.422   -30.040 -49.058 1.00 20.69  ? 247 ILE H CA   1 
ATOM   2918 C  C    . ILE B 2 232 ? 8.387   -31.311 -49.903 1.00 25.37  ? 247 ILE H C    1 
ATOM   2919 O  O    . ILE B 2 232 ? 9.267   -31.525 -50.745 1.00 31.74  ? 247 ILE H O    1 
ATOM   2920 C  CB   . ILE B 2 232 ? 8.883   -30.274 -47.610 1.00 20.27  ? 247 ILE H CB   1 
ATOM   2921 C  CG1  . ILE B 2 232 ? 9.415   -28.957 -47.042 1.00 21.01  ? 247 ILE H CG1  1 
ATOM   2922 C  CG2  . ILE B 2 232 ? 9.932   -31.371 -47.542 1.00 19.40  ? 247 ILE H CG2  1 
ATOM   2923 C  CD1  . ILE B 2 232 ? 9.388   -28.877 -45.551 1.00 22.45  ? 247 ILE H CD1  1 
ATOM   2924 N  N    . GLU B 2 233 ? 7.357   -32.133 -49.694 1.00 25.63  ? 248 GLU H N    1 
ATOM   2925 C  CA   . GLU B 2 233 ? 7.225   -33.390 -50.402 1.00 26.88  ? 248 GLU H CA   1 
ATOM   2926 C  C    . GLU B 2 233 ? 7.111   -33.102 -51.893 1.00 24.19  ? 248 GLU H C    1 
ATOM   2927 O  O    . GLU B 2 233 ? 7.730   -33.771 -52.701 1.00 26.29  ? 248 GLU H O    1 
ATOM   2928 C  CB   . GLU B 2 233 ? 6.069   -34.165 -49.768 1.00 32.10  ? 248 GLU H CB   1 
ATOM   2929 C  CG   . GLU B 2 233 ? 6.497   -34.758 -48.434 1.00 44.71  ? 248 GLU H CG   1 
ATOM   2930 C  CD   . GLU B 2 233 ? 5.510   -34.739 -47.276 1.00 61.88  ? 248 GLU H CD   1 
ATOM   2931 O  OE1  . GLU B 2 233 ? 4.372   -34.243 -47.457 1.00 69.58  ? 248 GLU H OE1  1 
ATOM   2932 O  OE2  . GLU B 2 233 ? 5.896   -35.216 -46.173 1.00 69.13  ? 248 GLU H OE2  1 
ATOM   2933 N  N    . TRP B 2 234 ? 6.374   -32.051 -52.236 1.00 22.59  ? 249 TRP H N    1 
ATOM   2934 C  CA   . TRP B 2 234 ? 6.142   -31.651 -53.608 1.00 21.56  ? 249 TRP H CA   1 
ATOM   2935 C  C    . TRP B 2 234 ? 7.439   -31.151 -54.245 1.00 22.64  ? 249 TRP H C    1 
ATOM   2936 O  O    . TRP B 2 234 ? 7.686   -31.350 -55.428 1.00 21.71  ? 249 TRP H O    1 
ATOM   2937 C  CB   . TRP B 2 234 ? 5.063   -30.564 -53.600 1.00 19.26  ? 249 TRP H CB   1 
ATOM   2938 C  CG   . TRP B 2 234 ? 4.672   -30.039 -54.952 1.00 19.82  ? 249 TRP H CG   1 
ATOM   2939 C  CD1  . TRP B 2 234 ? 3.777   -30.564 -55.835 1.00 20.46  ? 249 TRP H CD1  1 
ATOM   2940 C  CD2  . TRP B 2 234 ? 5.138   -28.817 -55.549 1.00 20.51  ? 249 TRP H CD2  1 
ATOM   2941 N  NE1  . TRP B 2 234 ? 3.652   -29.760 -56.936 1.00 19.34  ? 249 TRP H NE1  1 
ATOM   2942 C  CE2  . TRP B 2 234 ? 4.489   -28.688 -56.791 1.00 21.04  ? 249 TRP H CE2  1 
ATOM   2943 C  CE3  . TRP B 2 234 ? 6.043   -27.833 -55.157 1.00 21.33  ? 249 TRP H CE3  1 
ATOM   2944 C  CZ2  . TRP B 2 234 ? 4.723   -27.604 -57.636 1.00 22.56  ? 249 TRP H CZ2  1 
ATOM   2945 C  CZ3  . TRP B 2 234 ? 6.288   -26.778 -56.001 1.00 22.03  ? 249 TRP H CZ3  1 
ATOM   2946 C  CH2  . TRP B 2 234 ? 5.641   -26.667 -57.224 1.00 21.79  ? 249 TRP H CH2  1 
ATOM   2947 N  N    . LEU B 2 235 ? 8.270   -30.472 -53.451 1.00 23.96  ? 250 LEU H N    1 
ATOM   2948 C  CA   . LEU B 2 235 ? 9.559   -30.025 -53.942 1.00 24.56  ? 250 LEU H CA   1 
ATOM   2949 C  C    . LEU B 2 235 ? 10.453  -31.232 -54.172 1.00 24.55  ? 250 LEU H C    1 
ATOM   2950 O  O    . LEU B 2 235 ? 11.093  -31.316 -55.214 1.00 23.73  ? 250 LEU H O    1 
ATOM   2951 C  CB   . LEU B 2 235 ? 10.171  -29.048 -52.938 1.00 24.78  ? 250 LEU H CB   1 
ATOM   2952 C  CG   . LEU B 2 235 ? 9.411   -27.725 -52.821 1.00 24.49  ? 250 LEU H CG   1 
ATOM   2953 C  CD1  . LEU B 2 235 ? 9.913   -26.916 -51.640 1.00 24.72  ? 250 LEU H CD1  1 
ATOM   2954 C  CD2  . LEU B 2 235 ? 9.507   -26.924 -54.110 1.00 23.66  ? 250 LEU H CD2  1 
ATOM   2955 N  N    . GLN B 2 236 ? 10.502  -32.155 -53.207 1.00 24.70  ? 251 GLN H N    1 
ATOM   2956 C  CA   . GLN B 2 236 ? 11.394  -33.301 -53.338 1.00 30.76  ? 251 GLN H CA   1 
ATOM   2957 C  C    . GLN B 2 236 ? 11.021  -34.201 -54.522 1.00 35.31  ? 251 GLN H C    1 
ATOM   2958 O  O    . GLN B 2 236 ? 11.897  -34.727 -55.197 1.00 31.01  ? 251 GLN H O    1 
ATOM   2959 C  CB   . GLN B 2 236 ? 11.421  -34.095 -52.040 1.00 32.46  ? 251 GLN H CB   1 
ATOM   2960 C  CG   . GLN B 2 236 ? 12.344  -33.467 -51.017 1.00 34.13  ? 251 GLN H CG   1 
ATOM   2961 C  CD   . GLN B 2 236 ? 12.300  -34.192 -49.697 1.00 40.75  ? 251 GLN H CD   1 
ATOM   2962 O  OE1  . GLN B 2 236 ? 11.456  -35.057 -49.450 1.00 45.91  ? 251 GLN H OE1  1 
ATOM   2963 N  NE2  . GLN B 2 236 ? 13.201  -33.800 -48.812 1.00 46.80  ? 251 GLN H NE2  1 
ATOM   2964 N  N    . LYS B 2 237 ? 9.720   -34.365 -54.772 1.00 39.56  ? 252 LYS H N    1 
ATOM   2965 C  CA   . LYS B 2 237 ? 9.240   -35.261 -55.808 1.00 42.34  ? 252 LYS H CA   1 
ATOM   2966 C  C    . LYS B 2 237 ? 9.615   -34.672 -57.167 1.00 38.20  ? 252 LYS H C    1 
ATOM   2967 O  O    . LYS B 2 237 ? 10.008  -35.412 -58.060 1.00 39.21  ? 252 LYS H O    1 
ATOM   2968 C  CB   . LYS B 2 237 ? 7.746   -35.540 -55.567 1.00 48.47  ? 252 LYS H CB   1 
ATOM   2969 C  CG   . LYS B 2 237 ? 6.949   -36.122 -56.732 1.00 60.07  ? 252 LYS H CG   1 
ATOM   2970 C  CD   . LYS B 2 237 ? 6.317   -35.090 -57.674 1.00 71.25  ? 252 LYS H CD   1 
ATOM   2971 C  CE   . LYS B 2 237 ? 5.319   -34.154 -57.016 1.00 75.63  ? 252 LYS H CE   1 
ATOM   2972 N  NZ   . LYS B 2 237 ? 4.166   -34.892 -56.444 1.00 80.11  ? 252 LYS H NZ   1 
ATOM   2973 N  N    . LEU B 2 238 ? 9.532   -33.344 -57.306 1.00 34.71  ? 253 LEU H N    1 
ATOM   2974 C  CA   . LEU B 2 238 ? 9.837   -32.680 -58.564 1.00 34.33  ? 253 LEU H CA   1 
ATOM   2975 C  C    . LEU B 2 238 ? 11.343  -32.587 -58.792 1.00 31.02  ? 253 LEU H C    1 
ATOM   2976 O  O    . LEU B 2 238 ? 11.787  -32.481 -59.919 1.00 31.83  ? 253 LEU H O    1 
ATOM   2977 C  CB   . LEU B 2 238 ? 9.230   -31.273 -58.572 1.00 37.55  ? 253 LEU H CB   1 
ATOM   2978 C  CG   . LEU B 2 238 ? 7.728   -31.181 -58.838 1.00 40.30  ? 253 LEU H CG   1 
ATOM   2979 C  CD1  . LEU B 2 238 ? 7.233   -29.757 -58.624 1.00 38.46  ? 253 LEU H CD1  1 
ATOM   2980 C  CD2  . LEU B 2 238 ? 7.388   -31.662 -60.243 1.00 40.41  ? 253 LEU H CD2  1 
ATOM   2981 N  N    . MET B 2 239 ? 12.129  -32.595 -57.726 1.00 30.06  ? 254 MET H N    1 
ATOM   2982 C  CA   . MET B 2 239 ? 13.562  -32.464 -57.858 1.00 32.43  ? 254 MET H CA   1 
ATOM   2983 C  C    . MET B 2 239 ? 14.185  -33.774 -58.345 1.00 39.17  ? 254 MET H C    1 
ATOM   2984 O  O    . MET B 2 239 ? 15.334  -33.770 -58.784 1.00 38.15  ? 254 MET H O    1 
ATOM   2985 C  CB   . MET B 2 239 ? 14.171  -32.065 -56.514 1.00 34.20  ? 254 MET H CB   1 
ATOM   2986 C  CG   . MET B 2 239 ? 14.264  -30.556 -56.319 1.00 33.37  ? 254 MET H CG   1 
ATOM   2987 S  SD   . MET B 2 239 ? 15.381  -30.194 -54.972 1.00 28.93  ? 254 MET H SD   1 
ATOM   2988 C  CE   . MET B 2 239 ? 14.513  -31.067 -53.670 1.00 25.04  ? 254 MET H CE   1 
ATOM   2989 N  N    . ARG B 2 240 ? 13.427  -34.879 -58.246 1.00 46.33  ? 255 ARG H N    1 
ATOM   2990 C  CA   . ARG B 2 240 ? 13.819  -36.189 -58.753 1.00 50.50  ? 255 ARG H CA   1 
ATOM   2991 C  C    . ARG B 2 240 ? 13.042  -36.545 -60.023 1.00 50.15  ? 255 ARG H C    1 
ATOM   2992 O  O    . ARG B 2 240 ? 13.199  -37.634 -60.552 1.00 46.60  ? 255 ARG H O    1 
ATOM   2993 C  CB   . ARG B 2 240 ? 13.556  -37.269 -57.697 1.00 52.59  ? 255 ARG H CB   1 
ATOM   2994 C  CG   . ARG B 2 240 ? 14.269  -37.032 -56.373 1.00 57.27  ? 255 ARG H CG   1 
ATOM   2995 C  CD   . ARG B 2 240 ? 13.812  -37.972 -55.268 1.00 69.05  ? 255 ARG H CD   1 
ATOM   2996 N  NE   . ARG B 2 240 ? 12.352  -37.983 -55.107 1.00 77.85  ? 255 ARG H NE   1 
ATOM   2997 C  CZ   . ARG B 2 240 ? 11.691  -38.381 -54.019 1.00 66.58  ? 255 ARG H CZ   1 
ATOM   2998 N  NH1  . ARG B 2 240 ? 12.337  -38.825 -52.955 1.00 63.99  ? 255 ARG H NH1  1 
ATOM   2999 N  NH2  . ARG B 2 240 ? 10.373  -38.290 -53.992 1.00 60.67  ? 255 ARG H NH2  1 
ATOM   3000 N  N    . SER B 2 241 ? 12.221  -35.625 -60.531 1.00 55.62  ? 256 SER H N    1 
ATOM   3001 C  CA   . SER B 2 241 ? 11.410  -35.905 -61.701 1.00 65.25  ? 256 SER H CA   1 
ATOM   3002 C  C    . SER B 2 241 ? 12.192  -35.590 -62.972 1.00 66.75  ? 256 SER H C    1 
ATOM   3003 O  O    . SER B 2 241 ? 13.230  -34.928 -62.925 1.00 62.37  ? 256 SER H O    1 
ATOM   3004 C  CB   . SER B 2 241 ? 10.123  -35.139 -61.651 1.00 75.26  ? 256 SER H CB   1 
ATOM   3005 O  OG   . SER B 2 241 ? 9.148   -35.763 -62.471 1.00 85.27  ? 256 SER H OG   1 
ATOM   3006 N  N    . GLU B 2 242 ? 11.666  -36.067 -64.108 1.00 71.51  ? 257 GLU H N    1 
ATOM   3007 C  CA   . GLU B 2 242 ? 12.389  -36.019 -65.369 1.00 76.18  ? 257 GLU H CA   1 
ATOM   3008 C  C    . GLU B 2 242 ? 12.043  -34.715 -66.087 1.00 70.05  ? 257 GLU H C    1 
ATOM   3009 O  O    . GLU B 2 242 ? 10.870  -34.373 -66.246 1.00 66.84  ? 257 GLU H O    1 
ATOM   3010 C  CB   . GLU B 2 242 ? 12.062  -37.252 -66.218 1.00 89.10  ? 257 GLU H CB   1 
ATOM   3011 C  CG   . GLU B 2 242 ? 12.880  -37.355 -67.500 1.00 94.77  ? 257 GLU H CG   1 
ATOM   3012 C  CD   . GLU B 2 242 ? 12.581  -38.562 -68.379 1.00 94.63  ? 257 GLU H CD   1 
ATOM   3013 O  OE1  . GLU B 2 242 ? 11.925  -39.513 -67.906 1.00 101.50 ? 257 GLU H OE1  1 
ATOM   3014 O  OE2  . GLU B 2 242 ? 12.989  -38.536 -69.548 1.00 84.50  ? 257 GLU H OE2  1 
ATOM   3015 N  N    . PRO B 2 243 ? 13.052  -33.961 -66.576 1.00 59.12  ? 258 PRO H N    1 
ATOM   3016 C  CA   . PRO B 2 243 ? 12.806  -32.657 -67.196 1.00 61.83  ? 258 PRO H CA   1 
ATOM   3017 C  C    . PRO B 2 243 ? 11.779  -32.726 -68.334 1.00 67.31  ? 258 PRO H C    1 
ATOM   3018 O  O    . PRO B 2 243 ? 11.990  -33.447 -69.302 1.00 78.33  ? 258 PRO H O    1 
ATOM   3019 C  CB   . PRO B 2 243 ? 14.189  -32.233 -67.732 1.00 56.96  ? 258 PRO H CB   1 
ATOM   3020 C  CG   . PRO B 2 243 ? 15.178  -33.066 -66.943 1.00 59.53  ? 258 PRO H CG   1 
ATOM   3021 C  CD   . PRO B 2 243 ? 14.465  -34.360 -66.616 1.00 58.40  ? 258 PRO H CD   1 
ATOM   3022 N  N    . ARG B 2 244 ? 10.661  -31.997 -68.206 1.00 65.22  ? 259 ARG H N    1 
ATOM   3023 C  CA   . ARG B 2 244 ? 9.726   -31.793 -69.304 1.00 67.84  ? 259 ARG H CA   1 
ATOM   3024 C  C    . ARG B 2 244 ? 10.326  -30.812 -70.312 1.00 74.00  ? 259 ARG H C    1 
ATOM   3025 O  O    . ARG B 2 244 ? 11.308  -30.126 -70.019 1.00 72.60  ? 259 ARG H O    1 
ATOM   3026 C  CB   . ARG B 2 244 ? 8.375   -31.265 -68.805 1.00 78.30  ? 259 ARG H CB   1 
ATOM   3027 C  CG   . ARG B 2 244 ? 7.588   -32.217 -67.910 1.00 89.69  ? 259 ARG H CG   1 
ATOM   3028 C  CD   . ARG B 2 244 ? 7.142   -33.504 -68.578 1.00 101.95 ? 259 ARG H CD   1 
ATOM   3029 N  NE   . ARG B 2 244 ? 7.759   -34.696 -68.000 1.00 117.52 ? 259 ARG H NE   1 
ATOM   3030 C  CZ   . ARG B 2 244 ? 8.585   -35.534 -68.627 1.00 135.51 ? 259 ARG H CZ   1 
ATOM   3031 N  NH1  . ARG B 2 244 ? 9.083   -35.243 -69.819 1.00 137.45 ? 259 ARG H NH1  1 
ATOM   3032 N  NH2  . ARG B 2 244 ? 8.951   -36.659 -68.032 1.00 142.18 ? 259 ARG H NH2  1 
ATOM   3033 N  N    . PRO B 2 245 ? 9.758   -30.718 -71.539 1.00 76.52  ? 260 PRO H N    1 
ATOM   3034 C  CA   . PRO B 2 245 ? 10.383  -29.970 -72.634 1.00 78.53  ? 260 PRO H CA   1 
ATOM   3035 C  C    . PRO B 2 245 ? 10.142  -28.459 -72.665 1.00 75.47  ? 260 PRO H C    1 
ATOM   3036 O  O    . PRO B 2 245 ? 10.932  -27.742 -73.281 1.00 74.63  ? 260 PRO H O    1 
ATOM   3037 C  CB   . PRO B 2 245 ? 9.754   -30.589 -73.897 1.00 79.93  ? 260 PRO H CB   1 
ATOM   3038 C  CG   . PRO B 2 245 ? 8.918   -31.762 -73.397 1.00 76.27  ? 260 PRO H CG   1 
ATOM   3039 C  CD   . PRO B 2 245 ? 8.533   -31.394 -71.983 1.00 74.21  ? 260 PRO H CD   1 
ATOM   3040 N  N    . GLY B 2 246 ? 9.050   -27.990 -72.034 1.00 63.35  ? 261 GLY H N    1 
ATOM   3041 C  CA   . GLY B 2 246 ? 8.750   -26.563 -71.946 1.00 63.48  ? 261 GLY H CA   1 
ATOM   3042 C  C    . GLY B 2 246 ? 9.481   -25.871 -70.789 1.00 54.95  ? 261 GLY H C    1 
ATOM   3043 O  O    . GLY B 2 246 ? 10.019  -26.539 -69.904 1.00 55.21  ? 261 GLY H O    1 
ATOM   3044 N  N    . VAL B 2 247 ? 9.497   -24.529 -70.793 1.00 44.41  ? 262 VAL H N    1 
ATOM   3045 C  CA   . VAL B 2 247 ? 10.103  -23.804 -69.686 1.00 49.65  ? 262 VAL H CA   1 
ATOM   3046 C  C    . VAL B 2 247 ? 9.154   -23.805 -68.490 1.00 41.97  ? 262 VAL H C    1 
ATOM   3047 O  O    . VAL B 2 247 ? 9.497   -24.329 -67.437 1.00 38.20  ? 262 VAL H O    1 
ATOM   3048 C  CB   . VAL B 2 247 ? 10.521  -22.367 -70.043 1.00 51.77  ? 262 VAL H CB   1 
ATOM   3049 C  CG1  . VAL B 2 247 ? 11.012  -21.646 -68.795 1.00 56.39  ? 262 VAL H CG1  1 
ATOM   3050 C  CG2  . VAL B 2 247 ? 11.589  -22.342 -71.124 1.00 50.77  ? 262 VAL H CG2  1 
ATOM   3051 N  N    . LEU B 2 248 ? 7.973   -23.210 -68.677 1.00 38.40  ? 263 LEU H N    1 
ATOM   3052 C  CA   . LEU B 2 248 ? 6.953   -23.142 -67.649 1.00 35.30  ? 263 LEU H CA   1 
ATOM   3053 C  C    . LEU B 2 248 ? 6.225   -24.466 -67.579 1.00 30.23  ? 263 LEU H C    1 
ATOM   3054 O  O    . LEU B 2 248 ? 5.758   -24.962 -68.589 1.00 31.41  ? 263 LEU H O    1 
ATOM   3055 C  CB   . LEU B 2 248 ? 5.957   -22.034 -67.987 1.00 39.90  ? 263 LEU H CB   1 
ATOM   3056 C  CG   . LEU B 2 248 ? 4.823   -21.828 -66.988 1.00 44.70  ? 263 LEU H CG   1 
ATOM   3057 C  CD1  . LEU B 2 248 ? 5.361   -21.413 -65.627 1.00 44.91  ? 263 LEU H CD1  1 
ATOM   3058 C  CD2  . LEU B 2 248 ? 3.840   -20.782 -67.505 1.00 50.87  ? 263 LEU H CD2  1 
ATOM   3059 N  N    . LEU B 2 249 ? 6.048   -24.958 -66.359 1.00 29.73  ? 264 LEU H N    1 
ATOM   3060 C  CA   . LEU B 2 249 ? 5.421   -26.239 -66.123 1.00 30.05  ? 264 LEU H CA   1 
ATOM   3061 C  C    . LEU B 2 249 ? 4.513   -26.135 -64.904 1.00 28.06  ? 264 LEU H C    1 
ATOM   3062 O  O    . LEU B 2 249 ? 4.968   -25.806 -63.824 1.00 28.17  ? 264 LEU H O    1 
ATOM   3063 C  CB   . LEU B 2 249 ? 6.519   -27.280 -65.916 1.00 31.66  ? 264 LEU H CB   1 
ATOM   3064 C  CG   . LEU B 2 249 ? 6.028   -28.649 -65.460 1.00 38.04  ? 264 LEU H CG   1 
ATOM   3065 C  CD1  . LEU B 2 249 ? 5.189   -29.306 -66.535 1.00 40.35  ? 264 LEU H CD1  1 
ATOM   3066 C  CD2  . LEU B 2 249 ? 7.191   -29.561 -65.094 1.00 43.07  ? 264 LEU H CD2  1 
ATOM   3067 N  N    . ARG B 2 250 ? 3.228   -26.446 -65.076 1.00 27.96  ? 265 ARG H N    1 
ATOM   3068 C  CA   . ARG B 2 250 ? 2.303   -26.522 -63.956 1.00 26.79  ? 265 ARG H CA   1 
ATOM   3069 C  C    . ARG B 2 250 ? 2.227   -27.974 -63.477 1.00 28.46  ? 265 ARG H C    1 
ATOM   3070 O  O    . ARG B 2 250 ? 1.649   -28.822 -64.142 1.00 30.76  ? 265 ARG H O    1 
ATOM   3071 C  CB   . ARG B 2 250 ? 0.970   -25.901 -64.386 1.00 23.84  ? 265 ARG H CB   1 
ATOM   3072 C  CG   . ARG B 2 250 ? 1.130   -24.499 -64.953 1.00 25.22  ? 265 ARG H CG   1 
ATOM   3073 C  CD   . ARG B 2 250 ? -0.157  -23.791 -65.336 1.00 27.66  ? 265 ARG H CD   1 
ATOM   3074 N  NE   . ARG B 2 250 ? -1.204  -23.924 -64.315 1.00 32.88  ? 265 ARG H NE   1 
ATOM   3075 C  CZ   . ARG B 2 250 ? -2.313  -24.668 -64.404 1.00 32.77  ? 265 ARG H CZ   1 
ATOM   3076 N  NH1  . ARG B 2 250 ? -2.533  -25.447 -65.449 1.00 35.46  ? 265 ARG H NH1  1 
ATOM   3077 N  NH2  . ARG B 2 250 ? -3.205  -24.634 -63.433 1.00 32.90  ? 265 ARG H NH2  1 
ATOM   3078 N  N    . ALA B 2 251 ? 2.850   -28.272 -62.330 1.00 31.28  ? 266 ALA H N    1 
ATOM   3079 C  CA   . ALA B 2 251 ? 2.798   -29.606 -61.741 1.00 32.09  ? 266 ALA H CA   1 
ATOM   3080 C  C    . ALA B 2 251 ? 1.679   -29.683 -60.699 1.00 34.64  ? 266 ALA H C    1 
ATOM   3081 O  O    . ALA B 2 251 ? 1.493   -28.776 -59.894 1.00 35.44  ? 266 ALA H O    1 
ATOM   3082 C  CB   . ALA B 2 251 ? 4.125   -29.984 -61.113 1.00 29.90  ? 266 ALA H CB   1 
ATOM   3083 N  N    . PRO B 2 252 ? 0.929   -30.805 -60.639 1.00 35.02  ? 267 PRO H N    1 
ATOM   3084 C  CA   . PRO B 2 252 ? -0.173  -30.931 -59.695 1.00 31.74  ? 267 PRO H CA   1 
ATOM   3085 C  C    . PRO B 2 252 ? 0.276   -30.728 -58.254 1.00 30.07  ? 267 PRO H C    1 
ATOM   3086 O  O    . PRO B 2 252 ? 1.378   -31.139 -57.891 1.00 30.35  ? 267 PRO H O    1 
ATOM   3087 C  CB   . PRO B 2 252 ? -0.630  -32.392 -59.877 1.00 33.92  ? 267 PRO H CB   1 
ATOM   3088 C  CG   . PRO B 2 252 ? -0.132  -32.811 -61.233 1.00 31.34  ? 267 PRO H CG   1 
ATOM   3089 C  CD   . PRO B 2 252 ? 1.128   -32.019 -61.448 1.00 33.55  ? 267 PRO H CD   1 
ATOM   3090 N  N    . PHE B 2 253 ? -0.585  -30.084 -57.455 1.00 29.98  ? 268 PHE H N    1 
ATOM   3091 C  CA   . PHE B 2 253 ? -0.425  -30.034 -56.013 1.00 28.57  ? 268 PHE H CA   1 
ATOM   3092 C  C    . PHE B 2 253 ? -1.744  -30.432 -55.363 1.00 27.63  ? 268 PHE H C    1 
ATOM   3093 O  O    . PHE B 2 253 ? -2.810  -29.948 -55.737 1.00 25.18  ? 268 PHE H O    1 
ATOM   3094 C  CB   . PHE B 2 253 ? 0.020   -28.650 -55.520 1.00 27.79  ? 268 PHE H CB   1 
ATOM   3095 C  CG   . PHE B 2 253 ? 0.269   -28.591 -54.030 1.00 27.51  ? 268 PHE H CG   1 
ATOM   3096 C  CD1  . PHE B 2 253 ? 1.498   -28.934 -53.487 1.00 29.08  ? 268 PHE H CD1  1 
ATOM   3097 C  CD2  . PHE B 2 253 ? -0.755  -28.288 -53.142 1.00 28.72  ? 268 PHE H CD2  1 
ATOM   3098 C  CE1  . PHE B 2 253 ? 1.711   -28.917 -52.108 1.00 28.40  ? 268 PHE H CE1  1 
ATOM   3099 C  CE2  . PHE B 2 253 ? -0.548  -28.283 -51.762 1.00 27.13  ? 268 PHE H CE2  1 
ATOM   3100 C  CZ   . PHE B 2 253 ? 0.684   -28.597 -51.241 1.00 26.06  ? 268 PHE H CZ   1 
ATOM   3101 N  N    . PRO B 2 254 ? -1.732  -31.336 -54.371 1.00 30.54  ? 269 PRO H N    1 
ATOM   3102 C  CA   . PRO B 2 254 ? -0.535  -32.049 -53.952 1.00 32.60  ? 269 PRO H CA   1 
ATOM   3103 C  C    . PRO B 2 254 ? -0.228  -33.213 -54.889 1.00 31.67  ? 269 PRO H C    1 
ATOM   3104 O  O    . PRO B 2 254 ? 0.854   -33.670 -54.696 1.00 34.99  ? 269 PRO H O    1 
ATOM   3105 C  CB   . PRO B 2 254 ? -0.876  -32.640 -52.579 1.00 36.68  ? 269 PRO H CB   1 
ATOM   3106 C  CG   . PRO B 2 254 ? -2.279  -32.103 -52.265 1.00 37.23  ? 269 PRO H CG   1 
ATOM   3107 C  CD   . PRO B 2 254 ? -2.904  -31.755 -53.599 1.00 34.19  ? 269 PRO H CD   1 
ATOM   3108 N  N    . THR C 3 1   ? -13.081 -30.322 -30.793 1.00 47.80  ? 6   THR T N    1 
ATOM   3109 C  CA   . THR C 3 1   ? -11.937 -29.621 -30.146 1.00 47.64  ? 6   THR T CA   1 
ATOM   3110 C  C    . THR C 3 1   ? -12.392 -28.277 -29.568 1.00 43.64  ? 6   THR T C    1 
ATOM   3111 O  O    . THR C 3 1   ? -13.023 -27.473 -30.246 1.00 37.69  ? 6   THR T O    1 
ATOM   3112 C  CB   . THR C 3 1   ? -10.770 -29.480 -31.135 1.00 51.91  ? 6   THR T CB   1 
ATOM   3113 O  OG1  . THR C 3 1   ? -10.167 -30.769 -31.268 1.00 58.52  ? 6   THR T OG1  1 
ATOM   3114 C  CG2  . THR C 3 1   ? -9.705  -28.496 -30.698 1.00 52.45  ? 6   THR T CG2  1 
ATOM   3115 N  N    . VAL C 3 2   ? -12.025 -28.017 -28.313 1.00 39.63  ? 7   VAL T N    1 
ATOM   3116 C  CA   . VAL C 3 2   ? -12.302 -26.733 -27.691 1.00 42.48  ? 7   VAL T CA   1 
ATOM   3117 C  C    . VAL C 3 2   ? -10.993 -26.048 -27.261 1.00 39.05  ? 7   VAL T C    1 
ATOM   3118 O  O    . VAL C 3 2   ? -10.065 -26.662 -26.733 1.00 32.61  ? 7   VAL T O    1 
ATOM   3119 C  CB   . VAL C 3 2   ? -13.282 -26.905 -26.510 1.00 48.03  ? 7   VAL T CB   1 
ATOM   3120 C  CG1  . VAL C 3 2   ? -14.690 -27.250 -26.991 1.00 51.56  ? 7   VAL T CG1  1 
ATOM   3121 C  CG2  . VAL C 3 2   ? -12.800 -27.939 -25.502 1.00 46.33  ? 7   VAL T CG2  1 
ATOM   3122 N  N    . ALA C 3 3   ? -10.927 -24.736 -27.476 1.00 35.49  ? 8   ALA T N    1 
ATOM   3123 C  CA   . ALA C 3 3   ? -9.831  -23.951 -26.953 1.00 35.61  ? 8   ALA T CA   1 
ATOM   3124 C  C    . ALA C 3 3   ? -9.947  -23.958 -25.444 1.00 33.58  ? 8   ALA T C    1 
ATOM   3125 O  O    . ALA C 3 3   ? -11.062 -23.871 -24.941 1.00 35.81  ? 8   ALA T O    1 
ATOM   3126 C  CB   . ALA C 3 3   ? -9.871  -22.539 -27.495 1.00 37.73  ? 8   ALA T CB   1 
ATOM   3127 N  N    . ALA C 3 4   ? -8.804  -24.080 -24.750 1.00 32.70  ? 9   ALA T N    1 
ATOM   3128 C  CA   . ALA C 3 4   ? -8.782  -23.928 -23.304 1.00 28.78  ? 9   ALA T CA   1 
ATOM   3129 C  C    . ALA C 3 4   ? -9.228  -22.519 -22.948 1.00 27.41  ? 9   ALA T C    1 
ATOM   3130 O  O    . ALA C 3 4   ? -9.235  -21.623 -23.783 1.00 26.28  ? 9   ALA T O    1 
ATOM   3131 C  CB   . ALA C 3 4   ? -7.413  -24.203 -22.765 1.00 29.11  ? 9   ALA T CB   1 
ATOM   3132 N  N    . TYR C 3 5   ? -9.668  -22.331 -21.712 1.00 29.57  ? 10  TYR T N    1 
ATOM   3133 C  CA   . TYR C 3 5   ? -10.106 -21.009 -21.296 1.00 30.72  ? 10  TYR T CA   1 
ATOM   3134 C  C    . TYR C 3 5   ? -9.758  -20.850 -19.821 1.00 28.43  ? 10  TYR T C    1 
ATOM   3135 O  O    . TYR C 3 5   ? -9.415  -21.821 -19.149 1.00 27.24  ? 10  TYR T O    1 
ATOM   3136 C  CB   . TYR C 3 5   ? -11.574 -20.767 -21.687 1.00 29.97  ? 10  TYR T CB   1 
ATOM   3137 C  CG   . TYR C 3 5   ? -12.608 -21.705 -21.085 1.00 31.73  ? 10  TYR T CG   1 
ATOM   3138 C  CD1  . TYR C 3 5   ? -13.217 -21.415 -19.872 1.00 36.16  ? 10  TYR T CD1  1 
ATOM   3139 C  CD2  . TYR C 3 5   ? -13.001 -22.862 -21.740 1.00 38.23  ? 10  TYR T CD2  1 
ATOM   3140 C  CE1  . TYR C 3 5   ? -14.162 -22.260 -19.314 1.00 36.48  ? 10  TYR T CE1  1 
ATOM   3141 C  CE2  . TYR C 3 5   ? -13.928 -23.736 -21.187 1.00 39.73  ? 10  TYR T CE2  1 
ATOM   3142 C  CZ   . TYR C 3 5   ? -14.517 -23.418 -19.976 1.00 38.37  ? 10  TYR T CZ   1 
ATOM   3143 O  OH   . TYR C 3 5   ? -15.443 -24.228 -19.420 1.00 40.47  ? 10  TYR T OH   1 
ATOM   3144 N  N    . ASN C 3 6   ? -9.782  -19.595 -19.373 1.00 30.14  ? 11  ASN T N    1 
ATOM   3145 C  CA   . ASN C 3 6   ? -9.561  -19.240 -17.987 1.00 32.53  ? 11  ASN T CA   1 
ATOM   3146 C  C    . ASN C 3 6   ? -8.160  -19.666 -17.584 1.00 33.50  ? 11  ASN T C    1 
ATOM   3147 O  O    . ASN C 3 6   ? -7.940  -20.171 -16.483 1.00 37.41  ? 11  ASN T O    1 
ATOM   3148 C  CB   . ASN C 3 6   ? -10.613 -19.857 -17.063 1.00 38.43  ? 11  ASN T CB   1 
ATOM   3149 C  CG   . ASN C 3 6   ? -11.954 -19.160 -17.116 1.00 41.75  ? 11  ASN T CG   1 
ATOM   3150 O  OD1  . ASN C 3 6   ? -12.057 -18.018 -17.583 1.00 44.96  ? 11  ASN T OD1  1 
ATOM   3151 N  ND2  . ASN C 3 6   ? -12.972 -19.829 -16.590 1.00 39.67  ? 11  ASN T ND2  1 
ATOM   3152 N  N    . LEU C 3 7   ? -7.212  -19.437 -18.490 1.00 33.59  ? 12  LEU T N    1 
ATOM   3153 C  CA   . LEU C 3 7   ? -5.808  -19.621 -18.175 1.00 29.57  ? 12  LEU T CA   1 
ATOM   3154 C  C    . LEU C 3 7   ? -5.427  -18.704 -17.011 1.00 28.58  ? 12  LEU T C    1 
ATOM   3155 O  O    . LEU C 3 7   ? -5.551  -17.487 -17.103 1.00 26.80  ? 12  LEU T O    1 
ATOM   3156 C  CB   . LEU C 3 7   ? -4.977  -19.347 -19.431 1.00 27.79  ? 12  LEU T CB   1 
ATOM   3157 C  CG   . LEU C 3 7   ? -4.815  -20.537 -20.378 1.00 28.23  ? 12  LEU T CG   1 
ATOM   3158 C  CD1  . LEU C 3 7   ? -6.141  -20.913 -21.037 1.00 28.72  ? 12  LEU T CD1  1 
ATOM   3159 C  CD2  . LEU C 3 7   ? -3.763  -20.248 -21.434 1.00 29.50  ? 12  LEU T CD2  1 
ATOM   3160 N  N    . THR C 3 8   ? -4.903  -19.329 -15.953 1.00 27.57  ? 13  THR T N    1 
ATOM   3161 C  CA   . THR C 3 8   ? -4.654  -18.712 -14.668 1.00 26.78  ? 13  THR T CA   1 
ATOM   3162 C  C    . THR C 3 8   ? -3.269  -19.137 -14.196 1.00 26.53  ? 13  THR T C    1 
ATOM   3163 O  O    . THR C 3 8   ? -2.924  -20.312 -14.253 1.00 30.01  ? 13  THR T O    1 
ATOM   3164 C  CB   . THR C 3 8   ? -5.703  -19.174 -13.641 1.00 30.08  ? 13  THR T CB   1 
ATOM   3165 O  OG1  . THR C 3 8   ? -7.026  -19.020 -14.159 1.00 35.36  ? 13  THR T OG1  1 
ATOM   3166 C  CG2  . THR C 3 8   ? -5.653  -18.402 -12.345 1.00 31.40  ? 13  THR T CG2  1 
ATOM   3167 N  N    . TRP C 3 9   ? -2.507  -18.181 -13.676 1.00 26.57  ? 14  TRP T N    1 
ATOM   3168 C  CA   . TRP C 3 9   ? -1.201  -18.437 -13.098 1.00 27.79  ? 14  TRP T CA   1 
ATOM   3169 C  C    . TRP C 3 9   ? -1.315  -18.650 -11.593 1.00 30.31  ? 14  TRP T C    1 
ATOM   3170 O  O    . TRP C 3 9   ? -1.778  -17.732 -10.916 1.00 32.50  ? 14  TRP T O    1 
ATOM   3171 C  CB   . TRP C 3 9   ? -0.304  -17.222 -13.337 1.00 24.54  ? 14  TRP T CB   1 
ATOM   3172 C  CG   . TRP C 3 9   ? 0.066   -17.025 -14.769 1.00 22.66  ? 14  TRP T CG   1 
ATOM   3173 C  CD1  . TRP C 3 9   ? -0.528  -16.180 -15.651 1.00 21.99  ? 14  TRP T CD1  1 
ATOM   3174 C  CD2  . TRP C 3 9   ? 1.164   -17.654 -15.454 1.00 21.28  ? 14  TRP T CD2  1 
ATOM   3175 N  NE1  . TRP C 3 9   ? 0.114   -16.252 -16.854 1.00 22.98  ? 14  TRP T NE1  1 
ATOM   3176 C  CE2  . TRP C 3 9   ? 1.160   -17.138 -16.760 1.00 22.99  ? 14  TRP T CE2  1 
ATOM   3177 C  CE3  . TRP C 3 9   ? 2.132   -18.597 -15.092 1.00 22.65  ? 14  TRP T CE3  1 
ATOM   3178 C  CZ2  . TRP C 3 9   ? 2.093   -17.543 -17.712 1.00 24.84  ? 14  TRP T CZ2  1 
ATOM   3179 C  CZ3  . TRP C 3 9   ? 3.051   -19.008 -16.032 1.00 23.41  ? 14  TRP T CZ3  1 
ATOM   3180 C  CH2  . TRP C 3 9   ? 3.033   -18.477 -17.323 1.00 24.71  ? 14  TRP T CH2  1 
ATOM   3181 N  N    . LYS C 3 10  ? -0.820  -19.792 -11.079 1.00 28.68  ? 15  LYS T N    1 
ATOM   3182 C  CA   . LYS C 3 10  ? -0.777  -20.015 -9.640  1.00 29.92  ? 15  LYS T CA   1 
ATOM   3183 C  C    . LYS C 3 10  ? 0.669   -20.017 -9.167  1.00 29.31  ? 15  LYS T C    1 
ATOM   3184 O  O    . LYS C 3 10  ? 1.394   -20.996 -9.391  1.00 28.68  ? 15  LYS T O    1 
ATOM   3185 C  CB   . LYS C 3 10  ? -1.441  -21.327 -9.223  1.00 32.18  ? 15  LYS T CB   1 
ATOM   3186 C  CG   . LYS C 3 10  ? -2.955  -21.343 -9.349  1.00 39.57  ? 15  LYS T CG   1 
ATOM   3187 C  CD   . LYS C 3 10  ? -3.656  -20.369 -8.417  1.00 47.77  ? 15  LYS T CD   1 
ATOM   3188 C  CE   . LYS C 3 10  ? -5.165  -20.504 -8.434  1.00 51.94  ? 15  LYS T CE   1 
ATOM   3189 N  NZ   . LYS C 3 10  ? -5.658  -20.656 -9.823  1.00 63.67  ? 15  LYS T NZ   1 
ATOM   3190 N  N    . SER C 3 11  ? 1.064   -18.939 -8.470  1.00 24.80  ? 16  SER T N    1 
ATOM   3191 C  CA   . SER C 3 11  ? 2.453   -18.830 -8.078  1.00 23.10  ? 16  SER T CA   1 
ATOM   3192 C  C    . SER C 3 11  ? 2.613   -18.433 -6.614  1.00 20.96  ? 16  SER T C    1 
ATOM   3193 O  O    . SER C 3 11  ? 1.993   -17.510 -6.101  1.00 19.14  ? 16  SER T O    1 
ATOM   3194 C  CB   . SER C 3 11  ? 3.200   -17.909 -9.003  1.00 23.25  ? 16  SER T CB   1 
ATOM   3195 O  OG   . SER C 3 11  ? 4.601   -18.075 -8.825  1.00 22.23  ? 16  SER T OG   1 
ATOM   3196 N  N    . THR C 3 12  ? 3.512   -19.155 -5.956  1.00 19.82  ? 17  THR T N    1 
ATOM   3197 C  CA   . THR C 3 12  ? 3.813   -18.948 -4.560  1.00 19.97  ? 17  THR T CA   1 
ATOM   3198 C  C    . THR C 3 12  ? 5.259   -19.363 -4.342  1.00 19.40  ? 17  THR T C    1 
ATOM   3199 O  O    . THR C 3 12  ? 5.566   -20.556 -4.375  1.00 18.44  ? 17  THR T O    1 
ATOM   3200 C  CB   . THR C 3 12  ? 2.896   -19.764 -3.627  1.00 20.42  ? 17  THR T CB   1 
ATOM   3201 O  OG1  . THR C 3 12  ? 1.532   -19.392 -3.819  1.00 21.27  ? 17  THR T OG1  1 
ATOM   3202 C  CG2  . THR C 3 12  ? 3.228   -19.549 -2.166  1.00 20.42  ? 17  THR T CG2  1 
ATOM   3203 N  N    . ASN C 3 13  ? 6.105   -18.365 -4.068  1.00 19.86  ? 18  ASN T N    1 
ATOM   3204 C  CA   . ASN C 3 13  ? 7.522   -18.570 -3.829  1.00 21.08  ? 18  ASN T CA   1 
ATOM   3205 C  C    . ASN C 3 13  ? 8.162   -19.195 -5.066  1.00 20.05  ? 18  ASN T C    1 
ATOM   3206 O  O    . ASN C 3 13  ? 9.013   -20.070 -4.947  1.00 19.83  ? 18  ASN T O    1 
ATOM   3207 C  CB   . ASN C 3 13  ? 7.781   -19.413 -2.574  1.00 22.39  ? 18  ASN T CB   1 
ATOM   3208 C  CG   . ASN C 3 13  ? 7.630   -18.618 -1.299  1.00 24.45  ? 18  ASN T CG   1 
ATOM   3209 O  OD1  . ASN C 3 13  ? 7.308   -17.432 -1.319  1.00 25.18  ? 18  ASN T OD1  1 
ATOM   3210 N  ND2  . ASN C 3 13  ? 7.836   -19.273 -0.176  1.00 24.68  ? 18  ASN T ND2  1 
ATOM   3211 N  N    . PHE C 3 14  ? 7.738   -18.711 -6.235  1.00 20.88  ? 19  PHE T N    1 
ATOM   3212 C  CA   . PHE C 3 14  ? 8.269   -19.103 -7.536  1.00 23.03  ? 19  PHE T CA   1 
ATOM   3213 C  C    . PHE C 3 14  ? 7.797   -20.491 -7.970  1.00 22.46  ? 19  PHE T C    1 
ATOM   3214 O  O    . PHE C 3 14  ? 7.983   -20.837 -9.117  1.00 21.32  ? 19  PHE T O    1 
ATOM   3215 C  CB   . PHE C 3 14  ? 9.785   -18.889 -7.576  1.00 23.85  ? 19  PHE T CB   1 
ATOM   3216 C  CG   . PHE C 3 14  ? 10.138  -17.439 -7.359  1.00 23.41  ? 19  PHE T CG   1 
ATOM   3217 C  CD1  . PHE C 3 14  ? 9.974   -16.516 -8.374  1.00 22.15  ? 19  PHE T CD1  1 
ATOM   3218 C  CD2  . PHE C 3 14  ? 10.520  -16.981 -6.110  1.00 23.38  ? 19  PHE T CD2  1 
ATOM   3219 C  CE1  . PHE C 3 14  ? 10.219  -15.172 -8.158  1.00 23.19  ? 19  PHE T CE1  1 
ATOM   3220 C  CE2  . PHE C 3 14  ? 10.785  -15.638 -5.899  1.00 23.91  ? 19  PHE T CE2  1 
ATOM   3221 C  CZ   . PHE C 3 14  ? 10.632  -14.733 -6.923  1.00 24.02  ? 19  PHE T CZ   1 
ATOM   3222 N  N    . LYS C 3 15  ? 7.097   -21.240 -7.113  1.00 24.09  ? 20  LYS T N    1 
ATOM   3223 C  CA   . LYS C 3 15  ? 6.389   -22.418 -7.573  1.00 24.02  ? 20  LYS T CA   1 
ATOM   3224 C  C    . LYS C 3 15  ? 5.257   -21.946 -8.469  1.00 23.51  ? 20  LYS T C    1 
ATOM   3225 O  O    . LYS C 3 15  ? 4.296   -21.365 -7.977  1.00 26.45  ? 20  LYS T O    1 
ATOM   3226 C  CB   . LYS C 3 15  ? 5.797   -23.209 -6.408  1.00 25.04  ? 20  LYS T CB   1 
ATOM   3227 C  CG   . LYS C 3 15  ? 5.214   -24.560 -6.798  1.00 23.73  ? 20  LYS T CG   1 
ATOM   3228 C  CD   . LYS C 3 15  ? 6.280   -25.576 -7.095  1.00 21.85  ? 20  LYS T CD   1 
ATOM   3229 C  CE   . LYS C 3 15  ? 5.749   -26.873 -7.661  1.00 20.71  ? 20  LYS T CE   1 
ATOM   3230 N  NZ   . LYS C 3 15  ? 6.759   -27.944 -7.582  1.00 20.05  ? 20  LYS T NZ   1 
ATOM   3231 N  N    . THR C 3 16  ? 5.369   -22.202 -9.772  1.00 22.92  ? 21  THR T N    1 
ATOM   3232 C  CA   . THR C 3 16  ? 4.506   -21.539 -10.737 1.00 23.22  ? 21  THR T CA   1 
ATOM   3233 C  C    . THR C 3 16  ? 3.804   -22.599 -11.562 1.00 23.27  ? 21  THR T C    1 
ATOM   3234 O  O    . THR C 3 16  ? 4.481   -23.425 -12.179 1.00 24.32  ? 21  THR T O    1 
ATOM   3235 C  CB   . THR C 3 16  ? 5.293   -20.577 -11.632 1.00 23.90  ? 21  THR T CB   1 
ATOM   3236 O  OG1  . THR C 3 16  ? 6.091   -19.738 -10.791 1.00 27.92  ? 21  THR T OG1  1 
ATOM   3237 C  CG2  . THR C 3 16  ? 4.399   -19.715 -12.478 1.00 24.02  ? 21  THR T CG2  1 
ATOM   3238 N  N    . ILE C 3 17  ? 2.457   -22.541 -11.542 1.00 23.27  ? 22  ILE T N    1 
ATOM   3239 C  CA   . ILE C 3 17  ? 1.594   -23.544 -12.147 1.00 22.50  ? 22  ILE T CA   1 
ATOM   3240 C  C    . ILE C 3 17  ? 0.571   -22.858 -13.036 1.00 21.21  ? 22  ILE T C    1 
ATOM   3241 O  O    . ILE C 3 17  ? -0.233  -22.082 -12.549 1.00 24.09  ? 22  ILE T O    1 
ATOM   3242 C  CB   . ILE C 3 17  ? 0.833   -24.390 -11.112 1.00 23.83  ? 22  ILE T CB   1 
ATOM   3243 C  CG1  . ILE C 3 17  ? 1.699   -24.863 -9.945  1.00 26.11  ? 22  ILE T CG1  1 
ATOM   3244 C  CG2  . ILE C 3 17  ? 0.150   -25.549 -11.836 1.00 26.42  ? 22  ILE T CG2  1 
ATOM   3245 C  CD1  . ILE C 3 17  ? 2.256   -26.240 -10.080 1.00 27.57  ? 22  ILE T CD1  1 
ATOM   3246 N  N    . LEU C 3 18  ? 0.522   -23.227 -14.316 1.00 21.08  ? 23  LEU T N    1 
ATOM   3247 C  CA   . LEU C 3 18  ? -0.543  -22.759 -15.179 1.00 20.67  ? 23  LEU T CA   1 
ATOM   3248 C  C    . LEU C 3 18  ? -1.729  -23.707 -15.034 1.00 21.56  ? 23  LEU T C    1 
ATOM   3249 O  O    . LEU C 3 18  ? -1.534  -24.915 -14.912 1.00 20.19  ? 23  LEU T O    1 
ATOM   3250 C  CB   . LEU C 3 18  ? -0.071  -22.692 -16.630 1.00 20.38  ? 23  LEU T CB   1 
ATOM   3251 C  CG   . LEU C 3 18  ? -1.033  -21.940 -17.544 1.00 20.96  ? 23  LEU T CG   1 
ATOM   3252 C  CD1  . LEU C 3 18  ? -1.047  -20.462 -17.203 1.00 21.13  ? 23  LEU T CD1  1 
ATOM   3253 C  CD2  . LEU C 3 18  ? -0.672  -22.135 -19.003 1.00 22.36  ? 23  LEU T CD2  1 
ATOM   3254 N  N    . GLU C 3 19  ? -2.937  -23.125 -14.991 1.00 21.64  ? 24  GLU T N    1 
ATOM   3255 C  CA   . GLU C 3 19  ? -4.170  -23.878 -14.864 1.00 24.70  ? 24  GLU T CA   1 
ATOM   3256 C  C    . GLU C 3 19  ? -5.122  -23.339 -15.910 1.00 25.00  ? 24  GLU T C    1 
ATOM   3257 O  O    . GLU C 3 19  ? -5.056  -22.162 -16.285 1.00 26.19  ? 24  GLU T O    1 
ATOM   3258 C  CB   . GLU C 3 19  ? -4.830  -23.740 -13.483 1.00 27.12  ? 24  GLU T CB   1 
ATOM   3259 C  CG   . GLU C 3 19  ? -3.979  -24.277 -12.346 1.00 30.96  ? 24  GLU T CG   1 
ATOM   3260 C  CD   . GLU C 3 19  ? -4.678  -24.337 -10.994 1.00 33.08  ? 24  GLU T CD   1 
ATOM   3261 O  OE1  . GLU C 3 19  ? -5.800  -23.795 -10.889 1.00 31.94  ? 24  GLU T OE1  1 
ATOM   3262 O  OE2  . GLU C 3 19  ? -4.087  -24.920 -10.052 1.00 32.77  ? 24  GLU T OE2  1 
ATOM   3263 N  N    . TRP C 3 20  ? -5.997  -24.216 -16.379 1.00 23.67  ? 25  TRP T N    1 
ATOM   3264 C  CA   . TRP C 3 20  ? -6.986  -23.791 -17.346 1.00 23.93  ? 25  TRP T CA   1 
ATOM   3265 C  C    . TRP C 3 20  ? -8.183  -24.731 -17.234 1.00 26.65  ? 25  TRP T C    1 
ATOM   3266 O  O    . TRP C 3 20  ? -8.104  -25.739 -16.523 1.00 23.83  ? 25  TRP T O    1 
ATOM   3267 C  CB   . TRP C 3 20  ? -6.351  -23.747 -18.745 1.00 20.39  ? 25  TRP T CB   1 
ATOM   3268 C  CG   . TRP C 3 20  ? -5.862  -25.089 -19.213 1.00 19.79  ? 25  TRP T CG   1 
ATOM   3269 C  CD1  . TRP C 3 20  ? -6.596  -26.010 -19.897 1.00 19.69  ? 25  TRP T CD1  1 
ATOM   3270 C  CD2  . TRP C 3 20  ? -4.554  -25.675 -19.019 1.00 19.32  ? 25  TRP T CD2  1 
ATOM   3271 N  NE1  . TRP C 3 20  ? -5.835  -27.113 -20.162 1.00 21.54  ? 25  TRP T NE1  1 
ATOM   3272 C  CE2  . TRP C 3 20  ? -4.581  -26.942 -19.633 1.00 20.21  ? 25  TRP T CE2  1 
ATOM   3273 C  CE3  . TRP C 3 20  ? -3.370  -25.258 -18.401 1.00 19.56  ? 25  TRP T CE3  1 
ATOM   3274 C  CZ2  . TRP C 3 20  ? -3.484  -27.802 -19.626 1.00 20.78  ? 25  TRP T CZ2  1 
ATOM   3275 C  CZ3  . TRP C 3 20  ? -2.290  -26.113 -18.376 1.00 20.47  ? 25  TRP T CZ3  1 
ATOM   3276 C  CH2  . TRP C 3 20  ? -2.354  -27.378 -18.965 1.00 21.25  ? 25  TRP T CH2  1 
ATOM   3277 N  N    . GLU C 3 21  ? -9.280  -24.345 -17.906 1.00 28.62  ? 26  GLU T N    1 
ATOM   3278 C  CA   . GLU C 3 21  ? -10.385 -25.244 -18.191 1.00 32.60  ? 26  GLU T CA   1 
ATOM   3279 C  C    . GLU C 3 21  ? -10.391 -25.516 -19.699 1.00 33.22  ? 26  GLU T C    1 
ATOM   3280 O  O    . GLU C 3 21  ? -9.781  -24.775 -20.461 1.00 38.82  ? 26  GLU T O    1 
ATOM   3281 C  CB   . GLU C 3 21  ? -11.672 -24.613 -17.655 1.00 36.76  ? 26  GLU T CB   1 
ATOM   3282 C  CG   . GLU C 3 21  ? -11.426 -23.847 -16.374 1.00 42.88  ? 26  GLU T CG   1 
ATOM   3283 C  CD   . GLU C 3 21  ? -12.632 -23.528 -15.518 1.00 49.04  ? 26  GLU T CD   1 
ATOM   3284 O  OE1  . GLU C 3 21  ? -13.701 -23.238 -16.086 1.00 62.41  ? 26  GLU T OE1  1 
ATOM   3285 O  OE2  . GLU C 3 21  ? -12.478 -23.521 -14.281 1.00 56.68  ? 26  GLU T OE2  1 
ATOM   3286 N  N    . PRO C 3 22  ? -11.087 -26.546 -20.222 1.00 33.71  ? 27  PRO T N    1 
ATOM   3287 C  CA   . PRO C 3 22  ? -11.888 -27.481 -19.430 1.00 34.69  ? 27  PRO T CA   1 
ATOM   3288 C  C    . PRO C 3 22  ? -11.288 -28.871 -19.290 1.00 36.97  ? 27  PRO T C    1 
ATOM   3289 O  O    . PRO C 3 22  ? -10.266 -29.197 -19.893 1.00 43.69  ? 27  PRO T O    1 
ATOM   3290 C  CB   . PRO C 3 22  ? -13.114 -27.592 -20.342 1.00 34.85  ? 27  PRO T CB   1 
ATOM   3291 C  CG   . PRO C 3 22  ? -12.492 -27.654 -21.745 1.00 34.88  ? 27  PRO T CG   1 
ATOM   3292 C  CD   . PRO C 3 22  ? -11.243 -26.789 -21.665 1.00 34.07  ? 27  PRO T CD   1 
ATOM   3293 N  N    . LYS C 3 23  ? -11.959 -29.706 -18.512 1.00 41.42  ? 28  LYS T N    1 
ATOM   3294 C  CA   . LYS C 3 23  ? -11.596 -31.107 -18.477 1.00 44.65  ? 28  LYS T CA   1 
ATOM   3295 C  C    . LYS C 3 23  ? -11.734 -31.612 -19.906 1.00 41.65  ? 28  LYS T C    1 
ATOM   3296 O  O    . LYS C 3 23  ? -12.776 -31.401 -20.531 1.00 39.00  ? 28  LYS T O    1 
ATOM   3297 C  CB   . LYS C 3 23  ? -12.448 -31.893 -17.472 1.00 52.53  ? 28  LYS T CB   1 
ATOM   3298 C  CG   . LYS C 3 23  ? -12.464 -31.343 -16.048 1.00 59.58  ? 28  LYS T CG   1 
ATOM   3299 C  CD   . LYS C 3 23  ? -11.090 -31.139 -15.426 1.00 73.35  ? 28  LYS T CD   1 
ATOM   3300 C  CE   . LYS C 3 23  ? -10.325 -32.422 -15.165 1.00 84.22  ? 28  LYS T CE   1 
ATOM   3301 N  NZ   . LYS C 3 23  ? -10.900 -33.170 -14.020 1.00 91.92  ? 28  LYS T NZ   1 
ATOM   3302 N  N    . PRO C 3 24  ? -10.684 -32.280 -20.446 1.00 38.83  ? 29  PRO T N    1 
ATOM   3303 C  CA   . PRO C 3 24  ? -10.673 -32.725 -21.835 1.00 41.39  ? 29  PRO T CA   1 
ATOM   3304 C  C    . PRO C 3 24  ? -11.549 -33.951 -22.130 1.00 44.31  ? 29  PRO T C    1 
ATOM   3305 O  O    . PRO C 3 24  ? -11.592 -34.925 -21.375 1.00 37.33  ? 29  PRO T O    1 
ATOM   3306 C  CB   . PRO C 3 24  ? -9.181  -33.041 -22.074 1.00 40.12  ? 29  PRO T CB   1 
ATOM   3307 C  CG   . PRO C 3 24  ? -8.674  -33.506 -20.726 1.00 37.22  ? 29  PRO T CG   1 
ATOM   3308 C  CD   . PRO C 3 24  ? -9.468  -32.698 -19.721 1.00 38.13  ? 29  PRO T CD   1 
ATOM   3309 N  N    . VAL C 3 25  ? -12.237 -33.871 -23.274 1.00 51.04  ? 30  VAL T N    1 
ATOM   3310 C  CA   . VAL C 3 25  ? -13.026 -34.956 -23.826 1.00 53.63  ? 30  VAL T CA   1 
ATOM   3311 C  C    . VAL C 3 25  ? -12.492 -35.233 -25.228 1.00 48.67  ? 30  VAL T C    1 
ATOM   3312 O  O    . VAL C 3 25  ? -12.592 -34.367 -26.095 1.00 43.18  ? 30  VAL T O    1 
ATOM   3313 C  CB   . VAL C 3 25  ? -14.524 -34.589 -23.831 1.00 57.79  ? 30  VAL T CB   1 
ATOM   3314 C  CG1  . VAL C 3 25  ? -15.381 -35.595 -24.593 1.00 59.04  ? 30  VAL T CG1  1 
ATOM   3315 C  CG2  . VAL C 3 25  ? -15.049 -34.409 -22.415 1.00 56.07  ? 30  VAL T CG2  1 
ATOM   3316 N  N    . ASN C 3 26  ? -11.905 -36.431 -25.403 1.00 51.45  ? 31  ASN T N    1 
ATOM   3317 C  CA   . ASN C 3 26  ? -11.203 -36.821 -26.621 1.00 53.40  ? 31  ASN T CA   1 
ATOM   3318 C  C    . ASN C 3 26  ? -10.316 -35.693 -27.144 1.00 47.46  ? 31  ASN T C    1 
ATOM   3319 O  O    . ASN C 3 26  ? -10.370 -35.371 -28.326 1.00 49.77  ? 31  ASN T O    1 
ATOM   3320 C  CB   . ASN C 3 26  ? -12.178 -37.257 -27.719 1.00 61.86  ? 31  ASN T CB   1 
ATOM   3321 C  CG   . ASN C 3 26  ? -12.962 -38.499 -27.335 1.00 69.46  ? 31  ASN T CG   1 
ATOM   3322 O  OD1  . ASN C 3 26  ? -12.427 -39.612 -27.370 1.00 60.80  ? 31  ASN T OD1  1 
ATOM   3323 N  ND2  . ASN C 3 26  ? -14.227 -38.316 -26.974 1.00 64.37  ? 31  ASN T ND2  1 
ATOM   3324 N  N    . GLN C 3 27  ? -9.507  -35.099 -26.258 1.00 45.47  ? 32  GLN T N    1 
ATOM   3325 C  CA   . GLN C 3 27  ? -8.517  -34.099 -26.640 1.00 42.48  ? 32  GLN T CA   1 
ATOM   3326 C  C    . GLN C 3 27  ? -7.457  -33.983 -25.540 1.00 33.89  ? 32  GLN T C    1 
ATOM   3327 O  O    . GLN C 3 27  ? -7.699  -34.215 -24.369 1.00 36.77  ? 32  GLN T O    1 
ATOM   3328 C  CB   . GLN C 3 27  ? -9.177  -32.748 -26.961 1.00 39.63  ? 32  GLN T CB   1 
ATOM   3329 C  CG   . GLN C 3 27  ? -9.586  -31.938 -25.737 1.00 38.54  ? 32  GLN T CG   1 
ATOM   3330 C  CD   . GLN C 3 27  ? -10.133 -30.589 -26.132 1.00 37.86  ? 32  GLN T CD   1 
ATOM   3331 O  OE1  . GLN C 3 27  ? -10.725 -30.437 -27.199 1.00 44.04  ? 32  GLN T OE1  1 
ATOM   3332 N  NE2  . GLN C 3 27  ? -9.974  -29.605 -25.257 1.00 35.63  ? 32  GLN T NE2  1 
ATOM   3333 N  N    . VAL C 3 28  ? -6.253  -33.626 -25.940 1.00 32.09  ? 33  VAL T N    1 
ATOM   3334 C  CA   . VAL C 3 28  ? -5.118  -33.592 -25.041 1.00 29.26  ? 33  VAL T CA   1 
ATOM   3335 C  C    . VAL C 3 28  ? -4.548  -32.197 -25.200 1.00 26.24  ? 33  VAL T C    1 
ATOM   3336 O  O    . VAL C 3 28  ? -4.931  -31.512 -26.145 1.00 21.19  ? 33  VAL T O    1 
ATOM   3337 C  CB   . VAL C 3 28  ? -4.094  -34.688 -25.390 1.00 29.72  ? 33  VAL T CB   1 
ATOM   3338 C  CG1  . VAL C 3 28  ? -4.674  -36.086 -25.233 1.00 31.27  ? 33  VAL T CG1  1 
ATOM   3339 C  CG2  . VAL C 3 28  ? -3.542  -34.524 -26.787 1.00 29.05  ? 33  VAL T CG2  1 
ATOM   3340 N  N    . TYR C 3 29  ? -3.682  -31.800 -24.259 1.00 26.60  ? 34  TYR T N    1 
ATOM   3341 C  CA   . TYR C 3 29  ? -3.106  -30.464 -24.241 1.00 24.65  ? 34  TYR T CA   1 
ATOM   3342 C  C    . TYR C 3 29  ? -1.590  -30.538 -24.381 1.00 23.31  ? 34  TYR T C    1 
ATOM   3343 O  O    . TYR C 3 29  ? -0.957  -31.461 -23.890 1.00 23.18  ? 34  TYR T O    1 
ATOM   3344 C  CB   . TYR C 3 29  ? -3.527  -29.815 -22.928 1.00 25.28  ? 34  TYR T CB   1 
ATOM   3345 C  CG   . TYR C 3 29  ? -5.020  -29.577 -22.781 1.00 26.21  ? 34  TYR T CG   1 
ATOM   3346 C  CD1  . TYR C 3 29  ? -5.673  -28.634 -23.563 1.00 26.40  ? 34  TYR T CD1  1 
ATOM   3347 C  CD2  . TYR C 3 29  ? -5.763  -30.247 -21.815 1.00 28.22  ? 34  TYR T CD2  1 
ATOM   3348 C  CE1  . TYR C 3 29  ? -7.027  -28.382 -23.412 1.00 27.31  ? 34  TYR T CE1  1 
ATOM   3349 C  CE2  . TYR C 3 29  ? -7.120  -30.009 -21.656 1.00 29.07  ? 34  TYR T CE2  1 
ATOM   3350 C  CZ   . TYR C 3 29  ? -7.755  -29.083 -22.465 1.00 29.14  ? 34  TYR T CZ   1 
ATOM   3351 O  OH   . TYR C 3 29  ? -9.087  -28.854 -22.336 1.00 29.23  ? 34  TYR T OH   1 
ATOM   3352 N  N    . THR C 3 30  ? -1.010  -29.552 -25.070 1.00 22.73  ? 35  THR T N    1 
ATOM   3353 C  CA   . THR C 3 30  ? 0.400   -29.232 -24.894 1.00 22.27  ? 35  THR T CA   1 
ATOM   3354 C  C    . THR C 3 30  ? 0.552   -27.747 -24.579 1.00 20.79  ? 35  THR T C    1 
ATOM   3355 O  O    . THR C 3 30  ? -0.163  -26.918 -25.132 1.00 21.51  ? 35  THR T O    1 
ATOM   3356 C  CB   . THR C 3 30  ? 1.238   -29.623 -26.112 1.00 22.03  ? 35  THR T CB   1 
ATOM   3357 O  OG1  . THR C 3 30  ? 1.170   -31.043 -26.194 1.00 24.21  ? 35  THR T OG1  1 
ATOM   3358 C  CG2  . THR C 3 30  ? 2.677   -29.176 -26.014 1.00 21.72  ? 35  THR T CG2  1 
ATOM   3359 N  N    . VAL C 3 31  ? 1.502   -27.438 -23.696 1.00 19.14  ? 36  VAL T N    1 
ATOM   3360 C  CA   . VAL C 3 31  ? 1.743   -26.083 -23.250 1.00 20.43  ? 36  VAL T CA   1 
ATOM   3361 C  C    . VAL C 3 31  ? 3.053   -25.568 -23.848 1.00 20.42  ? 36  VAL T C    1 
ATOM   3362 O  O    . VAL C 3 31  ? 4.016   -26.314 -24.023 1.00 18.07  ? 36  VAL T O    1 
ATOM   3363 C  CB   . VAL C 3 31  ? 1.790   -26.036 -21.717 1.00 21.91  ? 36  VAL T CB   1 
ATOM   3364 C  CG1  . VAL C 3 31  ? 2.298   -24.688 -21.208 1.00 22.79  ? 36  VAL T CG1  1 
ATOM   3365 C  CG2  . VAL C 3 31  ? 0.431   -26.372 -21.142 1.00 22.79  ? 36  VAL T CG2  1 
ATOM   3366 N  N    . GLN C 3 32  ? 3.059   -24.271 -24.169 1.00 19.04  ? 37  GLN T N    1 
ATOM   3367 C  CA   . GLN C 3 32  ? 4.255   -23.613 -24.663 1.00 19.29  ? 37  GLN T CA   1 
ATOM   3368 C  C    . GLN C 3 32  ? 4.518   -22.395 -23.791 1.00 18.82  ? 37  GLN T C    1 
ATOM   3369 O  O    . GLN C 3 32  ? 3.602   -21.777 -23.279 1.00 20.05  ? 37  GLN T O    1 
ATOM   3370 C  CB   . GLN C 3 32  ? 4.114   -23.242 -26.138 1.00 18.42  ? 37  GLN T CB   1 
ATOM   3371 C  CG   . GLN C 3 32  ? 4.462   -24.377 -27.079 1.00 19.02  ? 37  GLN T CG   1 
ATOM   3372 C  CD   . GLN C 3 32  ? 4.604   -23.948 -28.532 1.00 19.32  ? 37  GLN T CD   1 
ATOM   3373 O  OE1  . GLN C 3 32  ? 4.251   -22.839 -28.938 1.00 17.36  ? 37  GLN T OE1  1 
ATOM   3374 N  NE2  . GLN C 3 32  ? 5.097   -24.866 -29.351 1.00 18.50  ? 37  GLN T NE2  1 
ATOM   3375 N  N    . ILE C 3 33  ? 5.785   -22.058 -23.610 1.00 19.76  ? 38  ILE T N    1 
ATOM   3376 C  CA   . ILE C 3 33  ? 6.124   -20.864 -22.858 1.00 20.68  ? 38  ILE T CA   1 
ATOM   3377 C  C    . ILE C 3 33  ? 7.306   -20.188 -23.543 1.00 20.51  ? 38  ILE T C    1 
ATOM   3378 O  O    . ILE C 3 33  ? 8.152   -20.888 -24.089 1.00 22.72  ? 38  ILE T O    1 
ATOM   3379 C  CB   . ILE C 3 33  ? 6.374   -21.215 -21.373 1.00 18.07  ? 38  ILE T CB   1 
ATOM   3380 C  CG1  . ILE C 3 33  ? 6.808   -19.974 -20.591 1.00 17.62  ? 38  ILE T CG1  1 
ATOM   3381 C  CG2  . ILE C 3 33  ? 7.366   -22.361 -21.219 1.00 16.95  ? 38  ILE T CG2  1 
ATOM   3382 C  CD1  . ILE C 3 33  ? 6.845   -20.179 -19.083 1.00 17.86  ? 38  ILE T CD1  1 
ATOM   3383 N  N    . SER C 3 34  ? 7.323   -18.845 -23.531 1.00 22.02  ? 39  SER T N    1 
ATOM   3384 C  CA   . SER C 3 34  ? 8.453   -18.037 -23.994 1.00 21.19  ? 39  SER T CA   1 
ATOM   3385 C  C    . SER C 3 34  ? 8.570   -16.729 -23.205 1.00 22.92  ? 39  SER T C    1 
ATOM   3386 O  O    . SER C 3 34  ? 7.644   -16.317 -22.519 1.00 25.49  ? 39  SER T O    1 
ATOM   3387 C  CB   . SER C 3 34  ? 8.344   -17.735 -25.460 1.00 19.88  ? 39  SER T CB   1 
ATOM   3388 O  OG   . SER C 3 34  ? 7.117   -17.074 -25.727 1.00 18.94  ? 39  SER T OG   1 
ATOM   3389 N  N    . THR C 3 35  ? 9.745   -16.093 -23.310 1.00 25.47  ? 40  THR T N    1 
ATOM   3390 C  CA   . THR C 3 35  ? 9.951   -14.670 -23.046 1.00 24.86  ? 40  THR T CA   1 
ATOM   3391 C  C    . THR C 3 35  ? 9.562   -13.863 -24.283 1.00 26.89  ? 40  THR T C    1 
ATOM   3392 O  O    . THR C 3 35  ? 9.295   -14.442 -25.335 1.00 26.87  ? 40  THR T O    1 
ATOM   3393 C  CB   . THR C 3 35  ? 11.412  -14.429 -22.658 1.00 20.46  ? 40  THR T CB   1 
ATOM   3394 O  OG1  . THR C 3 35  ? 12.225  -14.978 -23.684 1.00 21.17  ? 40  THR T OG1  1 
ATOM   3395 C  CG2  . THR C 3 35  ? 11.810  -15.116 -21.377 1.00 20.05  ? 40  THR T CG2  1 
ATOM   3396 N  N    . LYS C 3 36  ? 9.567   -12.532 -24.171 1.00 31.06  ? 41  LYS T N    1 
ATOM   3397 C  CA   . LYS C 3 36  ? 8.976   -11.686 -25.205 1.00 36.06  ? 41  LYS T CA   1 
ATOM   3398 C  C    . LYS C 3 36  ? 9.781   -11.779 -26.488 1.00 35.59  ? 41  LYS T C    1 
ATOM   3399 O  O    . LYS C 3 36  ? 9.264   -11.471 -27.553 1.00 39.14  ? 41  LYS T O    1 
ATOM   3400 C  CB   . LYS C 3 36  ? 8.939   -10.195 -24.831 1.00 46.24  ? 41  LYS T CB   1 
ATOM   3401 C  CG   . LYS C 3 36  ? 8.308   -9.823  -23.486 1.00 57.76  ? 41  LYS T CG   1 
ATOM   3402 C  CD   . LYS C 3 36  ? 6.772   -9.666  -23.468 1.00 66.87  ? 41  LYS T CD   1 
ATOM   3403 C  CE   . LYS C 3 36  ? 5.981   -10.934 -23.774 1.00 77.48  ? 41  LYS T CE   1 
ATOM   3404 N  NZ   . LYS C 3 36  ? 6.346   -12.113 -22.933 1.00 75.42  ? 41  LYS T NZ   1 
ATOM   3405 N  N    . SER C 3 37  ? 11.054  -12.164 -26.369 1.00 35.23  ? 42  SER T N    1 
ATOM   3406 C  CA   . SER C 3 37  ? 11.953  -12.212 -27.507 1.00 35.56  ? 42  SER T CA   1 
ATOM   3407 C  C    . SER C 3 37  ? 12.620  -13.588 -27.643 1.00 35.59  ? 42  SER T C    1 
ATOM   3408 O  O    . SER C 3 37  ? 13.608  -13.736 -28.377 1.00 38.75  ? 42  SER T O    1 
ATOM   3409 C  CB   . SER C 3 37  ? 12.993  -11.140 -27.346 1.00 36.54  ? 42  SER T CB   1 
ATOM   3410 O  OG   . SER C 3 37  ? 13.935  -11.534 -26.347 1.00 37.42  ? 42  SER T OG   1 
ATOM   3411 N  N    . GLY C 3 38  ? 12.112  -14.599 -26.922 1.00 28.17  ? 43  GLY T N    1 
ATOM   3412 C  CA   . GLY C 3 38  ? 12.742  -15.904 -26.919 1.00 23.35  ? 43  GLY T CA   1 
ATOM   3413 C  C    . GLY C 3 38  ? 11.957  -16.924 -27.736 1.00 20.86  ? 43  GLY T C    1 
ATOM   3414 O  O    . GLY C 3 38  ? 10.832  -16.690 -28.136 1.00 18.15  ? 43  GLY T O    1 
ATOM   3415 N  N    . ASP C 3 39  ? 12.537  -18.111 -27.891 1.00 21.47  ? 44  ASP T N    1 
ATOM   3416 C  CA   . ASP C 3 39  ? 11.869  -19.218 -28.561 1.00 21.44  ? 44  ASP T CA   1 
ATOM   3417 C  C    . ASP C 3 39  ? 10.742  -19.794 -27.694 1.00 21.28  ? 44  ASP T C    1 
ATOM   3418 O  O    . ASP C 3 39  ? 10.699  -19.618 -26.473 1.00 20.37  ? 44  ASP T O    1 
ATOM   3419 C  CB   . ASP C 3 39  ? 12.934  -20.221 -28.986 1.00 21.39  ? 44  ASP T CB   1 
ATOM   3420 C  CG   . ASP C 3 39  ? 13.872  -19.635 -30.036 1.00 23.42  ? 44  ASP T CG   1 
ATOM   3421 O  OD1  . ASP C 3 39  ? 13.463  -18.674 -30.731 1.00 23.22  ? 44  ASP T OD1  1 
ATOM   3422 O  OD2  . ASP C 3 39  ? 15.005  -20.140 -30.155 1.00 27.33  ? 44  ASP T OD2  1 
ATOM   3423 N  N    . TRP C 3 40  ? 9.787   -20.455 -28.355 1.00 19.63  ? 45  TRP T N    1 
ATOM   3424 C  CA   . TRP C 3 40  ? 8.726   -21.145 -27.645 1.00 19.77  ? 45  TRP T CA   1 
ATOM   3425 C  C    . TRP C 3 40  ? 9.198   -22.518 -27.195 1.00 21.12  ? 45  TRP T C    1 
ATOM   3426 O  O    . TRP C 3 40  ? 9.698   -23.290 -27.989 1.00 22.50  ? 45  TRP T O    1 
ATOM   3427 C  CB   . TRP C 3 40  ? 7.506   -21.287 -28.535 1.00 18.87  ? 45  TRP T CB   1 
ATOM   3428 C  CG   . TRP C 3 40  ? 6.824   -19.990 -28.849 1.00 16.99  ? 45  TRP T CG   1 
ATOM   3429 C  CD1  . TRP C 3 40  ? 6.910   -19.226 -29.968 1.00 16.01  ? 45  TRP T CD1  1 
ATOM   3430 C  CD2  . TRP C 3 40  ? 5.875   -19.337 -27.995 1.00 19.32  ? 45  TRP T CD2  1 
ATOM   3431 N  NE1  . TRP C 3 40  ? 6.067   -18.149 -29.884 1.00 16.88  ? 45  TRP T NE1  1 
ATOM   3432 C  CE2  . TRP C 3 40  ? 5.411   -18.184 -28.688 1.00 19.06  ? 45  TRP T CE2  1 
ATOM   3433 C  CE3  . TRP C 3 40  ? 5.371   -19.625 -26.726 1.00 18.31  ? 45  TRP T CE3  1 
ATOM   3434 C  CZ2  . TRP C 3 40  ? 4.485   -17.311 -28.136 1.00 18.03  ? 45  TRP T CZ2  1 
ATOM   3435 C  CZ3  . TRP C 3 40  ? 4.452   -18.759 -26.189 1.00 19.01  ? 45  TRP T CZ3  1 
ATOM   3436 C  CH2  . TRP C 3 40  ? 4.033   -17.621 -26.870 1.00 18.88  ? 45  TRP T CH2  1 
ATOM   3437 N  N    . LYS C 3 41  ? 9.049   -22.797 -25.907 1.00 23.02  ? 46  LYS T N    1 
ATOM   3438 C  CA   . LYS C 3 41  ? 9.511   -24.038 -25.326 1.00 26.17  ? 46  LYS T CA   1 
ATOM   3439 C  C    . LYS C 3 41  ? 8.256   -24.834 -24.953 1.00 23.48  ? 46  LYS T C    1 
ATOM   3440 O  O    . LYS C 3 41  ? 7.366   -24.283 -24.313 1.00 22.42  ? 46  LYS T O    1 
ATOM   3441 C  CB   . LYS C 3 41  ? 10.488  -23.665 -24.195 1.00 35.07  ? 46  LYS T CB   1 
ATOM   3442 C  CG   . LYS C 3 41  ? 10.693  -24.696 -23.087 1.00 49.81  ? 46  LYS T CG   1 
ATOM   3443 C  CD   . LYS C 3 41  ? 11.930  -25.612 -23.201 1.00 55.53  ? 46  LYS T CD   1 
ATOM   3444 C  CE   . LYS C 3 41  ? 11.791  -26.924 -22.443 1.00 53.39  ? 46  LYS T CE   1 
ATOM   3445 N  NZ   . LYS C 3 41  ? 10.966  -27.922 -23.187 1.00 52.15  ? 46  LYS T NZ   1 
ATOM   3446 N  N    . SER C 3 42  ? 8.186   -26.113 -25.380 1.00 21.44  ? 47  SER T N    1 
ATOM   3447 C  CA   . SER C 3 42  ? 7.048   -26.994 -25.115 1.00 20.09  ? 47  SER T CA   1 
ATOM   3448 C  C    . SER C 3 42  ? 7.168   -27.703 -23.761 1.00 20.90  ? 47  SER T C    1 
ATOM   3449 O  O    . SER C 3 42  ? 8.253   -28.082 -23.320 1.00 22.38  ? 47  SER T O    1 
ATOM   3450 C  CB   . SER C 3 42  ? 6.793   -27.944 -26.258 1.00 18.03  ? 47  SER T CB   1 
ATOM   3451 O  OG   . SER C 3 42  ? 6.179   -27.264 -27.360 1.00 16.71  ? 47  SER T OG   1 
ATOM   3452 N  N    . LYS C 3 43  ? 6.027   -27.807 -23.063 1.00 22.85  ? 48  LYS T N    1 
ATOM   3453 C  CA   . LYS C 3 43  ? 5.939   -28.446 -21.755 1.00 25.91  ? 48  LYS T CA   1 
ATOM   3454 C  C    . LYS C 3 43  ? 4.642   -29.243 -21.611 1.00 24.93  ? 48  LYS T C    1 
ATOM   3455 O  O    . LYS C 3 43  ? 3.645   -28.945 -22.266 1.00 21.53  ? 48  LYS T O    1 
ATOM   3456 C  CB   . LYS C 3 43  ? 5.943   -27.397 -20.642 1.00 30.73  ? 48  LYS T CB   1 
ATOM   3457 C  CG   . LYS C 3 43  ? 7.190   -26.528 -20.592 1.00 36.01  ? 48  LYS T CG   1 
ATOM   3458 C  CD   . LYS C 3 43  ? 8.389   -27.221 -20.023 1.00 35.95  ? 48  LYS T CD   1 
ATOM   3459 C  CE   . LYS C 3 43  ? 8.185   -27.494 -18.552 1.00 36.07  ? 48  LYS T CE   1 
ATOM   3460 N  NZ   . LYS C 3 43  ? 9.480   -27.728 -17.889 1.00 39.31  ? 48  LYS T NZ   1 
ATOM   3461 N  N    . CYS C 3 44  ? 4.677   -30.237 -20.702 1.00 24.43  ? 49  CYS T N    1 
ATOM   3462 C  CA   . CYS C 3 44  ? 3.507   -30.990 -20.284 1.00 23.97  ? 49  CYS T CA   1 
ATOM   3463 C  C    . CYS C 3 44  ? 2.838   -31.620 -21.506 1.00 24.74  ? 49  CYS T C    1 
ATOM   3464 O  O    . CYS C 3 44  ? 1.672   -31.359 -21.794 1.00 30.32  ? 49  CYS T O    1 
ATOM   3465 C  CB   . CYS C 3 44  ? 2.536   -30.112 -19.490 1.00 24.65  ? 49  CYS T CB   1 
ATOM   3466 S  SG   . CYS C 3 44  ? 3.200   -29.508 -17.907 1.00 23.41  ? 49  CYS T SG   1 
ATOM   3467 N  N    . PHE C 3 45  ? 3.582   -32.485 -22.200 1.00 24.31  ? 50  PHE T N    1 
ATOM   3468 C  CA   . PHE C 3 45  ? 3.253   -32.913 -23.557 1.00 24.25  ? 50  PHE T CA   1 
ATOM   3469 C  C    . PHE C 3 45  ? 2.055   -33.872 -23.577 1.00 22.12  ? 50  PHE T C    1 
ATOM   3470 O  O    . PHE C 3 45  ? 2.021   -34.898 -22.917 1.00 21.76  ? 50  PHE T O    1 
ATOM   3471 C  CB   . PHE C 3 45  ? 4.475   -33.540 -24.238 1.00 24.51  ? 50  PHE T CB   1 
ATOM   3472 C  CG   . PHE C 3 45  ? 5.760   -32.812 -23.956 1.00 23.49  ? 50  PHE T CG   1 
ATOM   3473 C  CD1  . PHE C 3 45  ? 6.134   -31.734 -24.724 1.00 23.48  ? 50  PHE T CD1  1 
ATOM   3474 C  CD2  . PHE C 3 45  ? 6.548   -33.161 -22.863 1.00 23.94  ? 50  PHE T CD2  1 
ATOM   3475 C  CE1  . PHE C 3 45  ? 7.316   -31.067 -24.444 1.00 24.98  ? 50  PHE T CE1  1 
ATOM   3476 C  CE2  . PHE C 3 45  ? 7.708   -32.475 -22.561 1.00 22.94  ? 50  PHE T CE2  1 
ATOM   3477 C  CZ   . PHE C 3 45  ? 8.090   -31.430 -23.359 1.00 24.84  ? 50  PHE T CZ   1 
ATOM   3478 N  N    . TYR C 3 46  ? 1.042   -33.499 -24.346 1.00 23.55  ? 51  TYR T N    1 
ATOM   3479 C  CA   . TYR C 3 46  ? -0.107  -34.353 -24.574 1.00 27.24  ? 51  TYR T CA   1 
ATOM   3480 C  C    . TYR C 3 46  ? -0.743  -34.771 -23.255 1.00 26.48  ? 51  TYR T C    1 
ATOM   3481 O  O    . TYR C 3 46  ? -1.088  -35.939 -23.108 1.00 30.36  ? 51  TYR T O    1 
ATOM   3482 C  CB   . TYR C 3 46  ? 0.325   -35.594 -25.362 1.00 27.87  ? 51  TYR T CB   1 
ATOM   3483 C  CG   . TYR C 3 46  ? 1.062   -35.268 -26.646 1.00 26.99  ? 51  TYR T CG   1 
ATOM   3484 C  CD1  . TYR C 3 46  ? 0.501   -34.441 -27.604 1.00 27.75  ? 51  TYR T CD1  1 
ATOM   3485 C  CD2  . TYR C 3 46  ? 2.321   -35.795 -26.890 1.00 31.93  ? 51  TYR T CD2  1 
ATOM   3486 C  CE1  . TYR C 3 46  ? 1.175   -34.152 -28.780 1.00 33.15  ? 51  TYR T CE1  1 
ATOM   3487 C  CE2  . TYR C 3 46  ? 3.019   -35.500 -28.051 1.00 31.92  ? 51  TYR T CE2  1 
ATOM   3488 C  CZ   . TYR C 3 46  ? 2.439   -34.680 -29.001 1.00 34.61  ? 51  TYR T CZ   1 
ATOM   3489 O  OH   . TYR C 3 46  ? 3.129   -34.407 -30.147 1.00 39.72  ? 51  TYR T OH   1 
ATOM   3490 N  N    . THR C 3 47  ? -0.946  -33.818 -22.333 1.00 24.51  ? 52  THR T N    1 
ATOM   3491 C  CA   . THR C 3 47  ? -1.465  -34.135 -21.017 1.00 23.59  ? 52  THR T CA   1 
ATOM   3492 C  C    . THR C 3 47  ? -2.988  -34.163 -21.045 1.00 23.69  ? 52  THR T C    1 
ATOM   3493 O  O    . THR C 3 47  ? -3.613  -33.462 -21.843 1.00 23.00  ? 52  THR T O    1 
ATOM   3494 C  CB   . THR C 3 47  ? -0.961  -33.158 -19.948 1.00 23.35  ? 52  THR T CB   1 
ATOM   3495 O  OG1  . THR C 3 47  ? -1.388  -33.665 -18.683 1.00 26.05  ? 52  THR T OG1  1 
ATOM   3496 C  CG2  . THR C 3 47  ? -1.497  -31.752 -20.084 1.00 23.77  ? 52  THR T CG2  1 
ATOM   3497 N  N    . THR C 3 48  ? -3.557  -34.949 -20.123 1.00 24.27  ? 53  THR T N    1 
ATOM   3498 C  CA   . THR C 3 48  ? -4.994  -35.003 -19.911 1.00 25.87  ? 53  THR T CA   1 
ATOM   3499 C  C    . THR C 3 48  ? -5.362  -34.103 -18.729 1.00 27.15  ? 53  THR T C    1 
ATOM   3500 O  O    . THR C 3 48  ? -6.531  -33.832 -18.494 1.00 27.69  ? 53  THR T O    1 
ATOM   3501 C  CB   . THR C 3 48  ? -5.464  -36.461 -19.818 1.00 26.35  ? 53  THR T CB   1 
ATOM   3502 O  OG1  . THR C 3 48  ? -4.576  -37.256 -19.037 1.00 31.48  ? 53  THR T OG1  1 
ATOM   3503 C  CG2  . THR C 3 48  ? -5.495  -37.142 -21.163 1.00 28.58  ? 53  THR T CG2  1 
ATOM   3504 N  N    . ASP C 3 49  ? -4.346  -33.581 -18.040 1.00 28.69  ? 54  ASP T N    1 
ATOM   3505 C  CA   . ASP C 3 49  ? -4.506  -32.671 -16.920 1.00 29.18  ? 54  ASP T CA   1 
ATOM   3506 C  C    . ASP C 3 49  ? -4.958  -31.287 -17.363 1.00 27.63  ? 54  ASP T C    1 
ATOM   3507 O  O    . ASP C 3 49  ? -4.882  -30.929 -18.538 1.00 29.55  ? 54  ASP T O    1 
ATOM   3508 C  CB   . ASP C 3 49  ? -3.156  -32.415 -16.254 1.00 34.51  ? 54  ASP T CB   1 
ATOM   3509 C  CG   . ASP C 3 49  ? -2.527  -33.641 -15.636 1.00 39.52  ? 54  ASP T CG   1 
ATOM   3510 O  OD1  . ASP C 3 49  ? -3.296  -34.559 -15.243 1.00 46.17  ? 54  ASP T OD1  1 
ATOM   3511 O  OD2  . ASP C 3 49  ? -1.278  -33.654 -15.532 1.00 46.91  ? 54  ASP T OD2  1 
ATOM   3512 N  N    . THR C 3 50  ? -5.351  -30.479 -16.377 1.00 26.47  ? 55  THR T N    1 
ATOM   3513 C  CA   . THR C 3 50  ? -5.745  -29.102 -16.621 1.00 27.08  ? 55  THR T CA   1 
ATOM   3514 C  C    . THR C 3 50  ? -4.808  -28.147 -15.878 1.00 25.57  ? 55  THR T C    1 
ATOM   3515 O  O    . THR C 3 50  ? -5.156  -26.991 -15.646 1.00 22.07  ? 55  THR T O    1 
ATOM   3516 C  CB   . THR C 3 50  ? -7.232  -28.924 -16.310 1.00 26.72  ? 55  THR T CB   1 
ATOM   3517 O  OG1  . THR C 3 50  ? -7.485  -29.697 -15.146 1.00 31.86  ? 55  THR T OG1  1 
ATOM   3518 C  CG2  . THR C 3 50  ? -8.128  -29.423 -17.423 1.00 26.44  ? 55  THR T CG2  1 
ATOM   3519 N  N    . GLU C 3 51  ? -3.585  -28.629 -15.603 1.00 25.72  ? 56  GLU T N    1 
ATOM   3520 C  CA   . GLU C 3 51  ? -2.515  -27.810 -15.062 1.00 24.24  ? 56  GLU T CA   1 
ATOM   3521 C  C    . GLU C 3 51  ? -1.176  -28.199 -15.690 1.00 23.25  ? 56  GLU T C    1 
ATOM   3522 O  O    . GLU C 3 51  ? -1.033  -29.290 -16.226 1.00 22.89  ? 56  GLU T O    1 
ATOM   3523 C  CB   . GLU C 3 51  ? -2.434  -28.004 -13.553 1.00 23.89  ? 56  GLU T CB   1 
ATOM   3524 C  CG   . GLU C 3 51  ? -1.904  -29.366 -13.137 1.00 24.09  ? 56  GLU T CG   1 
ATOM   3525 C  CD   . GLU C 3 51  ? -1.882  -29.573 -11.630 1.00 27.47  ? 56  GLU T CD   1 
ATOM   3526 O  OE1  . GLU C 3 51  ? -2.872  -29.229 -10.970 1.00 28.91  ? 56  GLU T OE1  1 
ATOM   3527 O  OE2  . GLU C 3 51  ? -0.856  -30.051 -11.113 1.00 33.84  ? 56  GLU T OE2  1 
ATOM   3528 N  N    . CYS C 3 52  ? -0.178  -27.319 -15.538 1.00 23.00  ? 57  CYS T N    1 
ATOM   3529 C  CA   . CYS C 3 52  ? 1.183   -27.577 -15.976 1.00 21.91  ? 57  CYS T CA   1 
ATOM   3530 C  C    . CYS C 3 52  ? 2.164   -26.849 -15.053 1.00 22.07  ? 57  CYS T C    1 
ATOM   3531 O  O    . CYS C 3 52  ? 2.076   -25.639 -14.867 1.00 21.05  ? 57  CYS T O    1 
ATOM   3532 C  CB   . CYS C 3 52  ? 1.365   -27.143 -17.427 1.00 21.10  ? 57  CYS T CB   1 
ATOM   3533 S  SG   . CYS C 3 52  ? 3.008   -27.514 -18.104 1.00 25.17  ? 57  CYS T SG   1 
ATOM   3534 N  N    . ASP C 3 53  ? 3.112   -27.587 -14.468 1.00 20.88  ? 58  ASP T N    1 
ATOM   3535 C  CA   . ASP C 3 53  ? 4.182   -26.949 -13.719 1.00 22.44  ? 58  ASP T CA   1 
ATOM   3536 C  C    . ASP C 3 53  ? 5.197   -26.328 -14.686 1.00 23.95  ? 58  ASP T C    1 
ATOM   3537 O  O    . ASP C 3 53  ? 5.826   -27.042 -15.471 1.00 23.02  ? 58  ASP T O    1 
ATOM   3538 C  CB   . ASP C 3 53  ? 4.865   -27.929 -12.766 1.00 21.95  ? 58  ASP T CB   1 
ATOM   3539 C  CG   . ASP C 3 53  ? 5.874   -27.268 -11.845 1.00 23.32  ? 58  ASP T CG   1 
ATOM   3540 O  OD1  . ASP C 3 53  ? 5.612   -26.133 -11.392 1.00 23.04  ? 58  ASP T OD1  1 
ATOM   3541 O  OD2  . ASP C 3 53  ? 6.897   -27.898 -11.579 1.00 23.91  ? 58  ASP T OD2  1 
ATOM   3542 N  N    . LEU C 3 54  ? 5.382   -25.001 -14.559 1.00 25.99  ? 59  LEU T N    1 
ATOM   3543 C  CA   . LEU C 3 54  ? 6.299   -24.211 -15.371 1.00 24.90  ? 59  LEU T CA   1 
ATOM   3544 C  C    . LEU C 3 54  ? 7.432   -23.627 -14.531 1.00 25.20  ? 59  LEU T C    1 
ATOM   3545 O  O    . LEU C 3 54  ? 8.212   -22.821 -15.037 1.00 23.65  ? 59  LEU T O    1 
ATOM   3546 C  CB   . LEU C 3 54  ? 5.477   -23.100 -16.030 1.00 28.06  ? 59  LEU T CB   1 
ATOM   3547 C  CG   . LEU C 3 54  ? 4.502   -23.606 -17.104 1.00 30.85  ? 59  LEU T CG   1 
ATOM   3548 C  CD1  . LEU C 3 54  ? 3.564   -22.509 -17.591 1.00 30.36  ? 59  LEU T CD1  1 
ATOM   3549 C  CD2  . LEU C 3 54  ? 5.266   -24.212 -18.278 1.00 29.27  ? 59  LEU T CD2  1 
ATOM   3550 N  N    . THR C 3 55  ? 7.523   -24.053 -13.258 1.00 25.74  ? 60  THR T N    1 
ATOM   3551 C  CA   . THR C 3 55  ? 8.518   -23.566 -12.309 1.00 25.46  ? 60  THR T CA   1 
ATOM   3552 C  C    . THR C 3 55  ? 9.929   -23.633 -12.891 1.00 27.30  ? 60  THR T C    1 
ATOM   3553 O  O    . THR C 3 55  ? 10.713  -22.702 -12.749 1.00 28.76  ? 60  THR T O    1 
ATOM   3554 C  CB   . THR C 3 55  ? 8.504   -24.395 -11.018 1.00 23.03  ? 60  THR T CB   1 
ATOM   3555 O  OG1  . THR C 3 55  ? 7.184   -24.376 -10.471 1.00 24.98  ? 60  THR T OG1  1 
ATOM   3556 C  CG2  . THR C 3 55  ? 9.488   -23.895 -9.993  1.00 21.04  ? 60  THR T CG2  1 
ATOM   3557 N  N    . ASP C 3 56  ? 10.276  -24.752 -13.522 1.00 28.34  ? 61  ASP T N    1 
ATOM   3558 C  CA   . ASP C 3 56  ? 11.660  -24.952 -13.909 1.00 28.07  ? 61  ASP T CA   1 
ATOM   3559 C  C    . ASP C 3 56  ? 12.052  -23.960 -15.000 1.00 28.27  ? 61  ASP T C    1 
ATOM   3560 O  O    . ASP C 3 56  ? 13.225  -23.635 -15.095 1.00 31.36  ? 61  ASP T O    1 
ATOM   3561 C  CB   . ASP C 3 56  ? 11.931  -26.401 -14.332 1.00 29.60  ? 61  ASP T CB   1 
ATOM   3562 C  CG   . ASP C 3 56  ? 12.256  -27.362 -13.193 1.00 29.07  ? 61  ASP T CG   1 
ATOM   3563 O  OD1  . ASP C 3 56  ? 12.623  -26.883 -12.121 1.00 28.50  ? 61  ASP T OD1  1 
ATOM   3564 O  OD2  . ASP C 3 56  ? 12.170  -28.602 -13.408 1.00 29.20  ? 61  ASP T OD2  1 
ATOM   3565 N  N    . GLU C 3 57  ? 11.107  -23.482 -15.820 1.00 28.29  ? 62  GLU T N    1 
ATOM   3566 C  CA   . GLU C 3 57  ? 11.435  -22.470 -16.819 1.00 30.20  ? 62  GLU T CA   1 
ATOM   3567 C  C    . GLU C 3 57  ? 11.588  -21.096 -16.179 1.00 29.73  ? 62  GLU T C    1 
ATOM   3568 O  O    . GLU C 3 57  ? 12.570  -20.403 -16.444 1.00 36.64  ? 62  GLU T O    1 
ATOM   3569 C  CB   . GLU C 3 57  ? 10.371  -22.324 -17.910 1.00 32.40  ? 62  GLU T CB   1 
ATOM   3570 C  CG   . GLU C 3 57  ? 10.298  -23.496 -18.856 1.00 36.26  ? 62  GLU T CG   1 
ATOM   3571 C  CD   . GLU C 3 57  ? 11.655  -23.999 -19.340 1.00 41.52  ? 62  GLU T CD   1 
ATOM   3572 O  OE1  . GLU C 3 57  ? 12.467  -23.156 -19.858 1.00 35.13  ? 62  GLU T OE1  1 
ATOM   3573 O  OE2  . GLU C 3 57  ? 11.908  -25.233 -19.161 1.00 41.44  ? 62  GLU T OE2  1 
ATOM   3574 N  N    . ILE C 3 58  ? 10.609  -20.691 -15.361 1.00 26.86  ? 63  ILE T N    1 
ATOM   3575 C  CA   . ILE C 3 58  ? 10.537  -19.310 -14.911 1.00 24.79  ? 63  ILE T CA   1 
ATOM   3576 C  C    . ILE C 3 58  ? 11.677  -18.992 -13.954 1.00 24.03  ? 63  ILE T C    1 
ATOM   3577 O  O    . ILE C 3 58  ? 12.097  -17.842 -13.943 1.00 22.64  ? 63  ILE T O    1 
ATOM   3578 C  CB   . ILE C 3 58  ? 9.156   -18.947 -14.332 1.00 23.64  ? 63  ILE T CB   1 
ATOM   3579 C  CG1  . ILE C 3 58  ? 8.846   -19.634 -13.001 1.00 24.06  ? 63  ILE T CG1  1 
ATOM   3580 C  CG2  . ILE C 3 58  ? 8.085   -19.212 -15.373 1.00 23.37  ? 63  ILE T CG2  1 
ATOM   3581 C  CD1  . ILE C 3 58  ? 9.131   -18.775 -11.796 1.00 25.43  ? 63  ILE T CD1  1 
ATOM   3582 N  N    . VAL C 3 59  ? 12.206  -19.987 -13.215 1.00 24.25  ? 64  VAL T N    1 
ATOM   3583 C  CA   . VAL C 3 59  ? 13.256  -19.713 -12.233 1.00 27.05  ? 64  VAL T CA   1 
ATOM   3584 C  C    . VAL C 3 59  ? 14.606  -19.484 -12.928 1.00 30.89  ? 64  VAL T C    1 
ATOM   3585 O  O    . VAL C 3 59  ? 15.581  -19.064 -12.294 1.00 28.66  ? 64  VAL T O    1 
ATOM   3586 C  CB   . VAL C 3 59  ? 13.382  -20.804 -11.151 1.00 26.91  ? 64  VAL T CB   1 
ATOM   3587 C  CG1  . VAL C 3 59  ? 12.132  -20.909 -10.296 1.00 26.22  ? 64  VAL T CG1  1 
ATOM   3588 C  CG2  . VAL C 3 59  ? 13.741  -22.152 -11.741 1.00 28.34  ? 64  VAL T CG2  1 
ATOM   3589 N  N    . LYS C 3 60  ? 14.669  -19.750 -14.238 1.00 32.03  ? 65  LYS T N    1 
ATOM   3590 C  CA   . LYS C 3 60  ? 15.874  -19.462 -14.992 1.00 31.85  ? 65  LYS T CA   1 
ATOM   3591 C  C    . LYS C 3 60  ? 16.145  -17.963 -14.992 1.00 26.71  ? 65  LYS T C    1 
ATOM   3592 O  O    . LYS C 3 60  ? 17.288  -17.564 -14.940 1.00 23.43  ? 65  LYS T O    1 
ATOM   3593 C  CB   . LYS C 3 60  ? 15.765  -20.017 -16.408 1.00 34.99  ? 65  LYS T CB   1 
ATOM   3594 C  CG   . LYS C 3 60  ? 15.853  -21.532 -16.470 1.00 41.72  ? 65  LYS T CG   1 
ATOM   3595 C  CD   . LYS C 3 60  ? 15.469  -22.076 -17.828 1.00 50.30  ? 65  LYS T CD   1 
ATOM   3596 C  CE   . LYS C 3 60  ? 15.424  -23.588 -17.890 1.00 53.10  ? 65  LYS T CE   1 
ATOM   3597 N  NZ   . LYS C 3 60  ? 14.895  -24.047 -19.194 1.00 56.43  ? 65  LYS T NZ   1 
ATOM   3598 N  N    . ASP C 3 61  ? 15.096  -17.145 -15.049 1.00 25.68  ? 66  ASP T N    1 
ATOM   3599 C  CA   . ASP C 3 61  ? 15.243  -15.715 -14.861 1.00 25.48  ? 66  ASP T CA   1 
ATOM   3600 C  C    . ASP C 3 61  ? 13.907  -15.151 -14.378 1.00 23.44  ? 66  ASP T C    1 
ATOM   3601 O  O    . ASP C 3 61  ? 12.985  -14.999 -15.173 1.00 18.66  ? 66  ASP T O    1 
ATOM   3602 C  CB   . ASP C 3 61  ? 15.780  -15.069 -16.146 1.00 26.49  ? 66  ASP T CB   1 
ATOM   3603 C  CG   . ASP C 3 61  ? 16.052  -13.577 -16.037 1.00 29.63  ? 66  ASP T CG   1 
ATOM   3604 O  OD1  . ASP C 3 61  ? 15.617  -12.949 -15.033 1.00 35.45  ? 66  ASP T OD1  1 
ATOM   3605 O  OD2  . ASP C 3 61  ? 16.685  -13.041 -16.949 1.00 30.43  ? 66  ASP T OD2  1 
ATOM   3606 N  N    . VAL C 3 62  ? 13.831  -14.798 -13.084 1.00 26.84  ? 67  VAL T N    1 
ATOM   3607 C  CA   . VAL C 3 62  ? 12.571  -14.413 -12.452 1.00 30.44  ? 67  VAL T CA   1 
ATOM   3608 C  C    . VAL C 3 62  ? 12.145  -12.991 -12.833 1.00 31.88  ? 67  VAL T C    1 
ATOM   3609 O  O    . VAL C 3 62  ? 10.988  -12.635 -12.586 1.00 32.89  ? 67  VAL T O    1 
ATOM   3610 C  CB   . VAL C 3 62  ? 12.606  -14.549 -10.915 1.00 32.78  ? 67  VAL T CB   1 
ATOM   3611 C  CG1  . VAL C 3 62  ? 13.097  -15.917 -10.470 1.00 34.81  ? 67  VAL T CG1  1 
ATOM   3612 C  CG2  . VAL C 3 62  ? 13.434  -13.460 -10.249 1.00 33.93  ? 67  VAL T CG2  1 
ATOM   3613 N  N    . LYS C 3 63  ? 13.054  -12.184 -13.411 1.00 33.79  ? 68  LYS T N    1 
ATOM   3614 C  CA   . LYS C 3 63  ? 12.753  -10.798 -13.771 1.00 35.53  ? 68  LYS T CA   1 
ATOM   3615 C  C    . LYS C 3 63  ? 12.183  -10.699 -15.187 1.00 31.31  ? 68  LYS T C    1 
ATOM   3616 O  O    . LYS C 3 63  ? 11.700  -9.636  -15.578 1.00 30.03  ? 68  LYS T O    1 
ATOM   3617 C  CB   . LYS C 3 63  ? 13.999  -9.894  -13.757 1.00 45.16  ? 68  LYS T CB   1 
ATOM   3618 C  CG   . LYS C 3 63  ? 14.750  -9.718  -12.438 1.00 48.36  ? 68  LYS T CG   1 
ATOM   3619 C  CD   . LYS C 3 63  ? 14.142  -8.670  -11.525 1.00 56.72  ? 68  LYS T CD   1 
ATOM   3620 C  CE   . LYS C 3 63  ? 15.109  -8.134  -10.488 1.00 56.29  ? 68  LYS T CE   1 
ATOM   3621 N  NZ   . LYS C 3 63  ? 15.889  -9.238  -9.893  1.00 53.65  ? 68  LYS T NZ   1 
ATOM   3622 N  N    . GLN C 3 64  ? 12.237  -11.781 -15.974 1.00 27.99  ? 69  GLN T N    1 
ATOM   3623 C  CA   . GLN C 3 64  ? 11.645  -11.740 -17.306 1.00 28.12  ? 69  GLN T CA   1 
ATOM   3624 C  C    . GLN C 3 64  ? 10.128  -11.782 -17.195 1.00 24.01  ? 69  GLN T C    1 
ATOM   3625 O  O    . GLN C 3 64  ? 9.632   -12.355 -16.251 1.00 26.94  ? 69  GLN T O    1 
ATOM   3626 C  CB   . GLN C 3 64  ? 12.116  -12.913 -18.166 1.00 33.46  ? 69  GLN T CB   1 
ATOM   3627 C  CG   . GLN C 3 64  ? 13.497  -12.736 -18.770 1.00 38.73  ? 69  GLN T CG   1 
ATOM   3628 C  CD   . GLN C 3 64  ? 13.522  -11.640 -19.808 1.00 46.16  ? 69  GLN T CD   1 
ATOM   3629 O  OE1  . GLN C 3 64  ? 13.535  -11.898 -21.012 1.00 40.61  ? 69  GLN T OE1  1 
ATOM   3630 N  NE2  . GLN C 3 64  ? 13.533  -10.395 -19.347 1.00 54.71  ? 69  GLN T NE2  1 
ATOM   3631 N  N    . THR C 3 65  ? 9.417   -11.151 -18.136 1.00 22.46  ? 70  THR T N    1 
ATOM   3632 C  CA   . THR C 3 65  ? 8.013   -11.426 -18.409 1.00 24.53  ? 70  THR T CA   1 
ATOM   3633 C  C    . THR C 3 65  ? 7.874   -12.643 -19.326 1.00 25.59  ? 70  THR T C    1 
ATOM   3634 O  O    . THR C 3 65  ? 8.603   -12.760 -20.311 1.00 28.70  ? 70  THR T O    1 
ATOM   3635 C  CB   . THR C 3 65  ? 7.305   -10.227 -19.047 1.00 25.00  ? 70  THR T CB   1 
ATOM   3636 O  OG1  . THR C 3 65  ? 7.359   -9.108  -18.148 1.00 25.95  ? 70  THR T OG1  1 
ATOM   3637 C  CG2  . THR C 3 65  ? 5.855   -10.528 -19.360 1.00 25.34  ? 70  THR T CG2  1 
ATOM   3638 N  N    . TYR C 3 66  ? 6.983   -13.582 -18.960 1.00 24.78  ? 71  TYR T N    1 
ATOM   3639 C  CA   . TYR C 3 66  ? 6.739   -14.776 -19.760 1.00 24.99  ? 71  TYR T CA   1 
ATOM   3640 C  C    . TYR C 3 66  ? 5.331   -14.738 -20.332 1.00 29.09  ? 71  TYR T C    1 
ATOM   3641 O  O    . TYR C 3 66  ? 4.445   -14.142 -19.714 1.00 30.58  ? 71  TYR T O    1 
ATOM   3642 C  CB   . TYR C 3 66  ? 6.869   -16.091 -19.001 1.00 21.88  ? 71  TYR T CB   1 
ATOM   3643 C  CG   . TYR C 3 66  ? 8.272   -16.224 -18.447 1.00 22.14  ? 71  TYR T CG   1 
ATOM   3644 C  CD1  . TYR C 3 66  ? 9.224   -17.008 -19.077 1.00 20.56  ? 71  TYR T CD1  1 
ATOM   3645 C  CD2  . TYR C 3 66  ? 8.654   -15.531 -17.305 1.00 23.22  ? 71  TYR T CD2  1 
ATOM   3646 C  CE1  . TYR C 3 66  ? 10.510  -17.121 -18.577 1.00 22.63  ? 71  TYR T CE1  1 
ATOM   3647 C  CE2  . TYR C 3 66  ? 9.935   -15.649 -16.782 1.00 22.91  ? 71  TYR T CE2  1 
ATOM   3648 C  CZ   . TYR C 3 66  ? 10.871  -16.435 -17.428 1.00 22.92  ? 71  TYR T CZ   1 
ATOM   3649 O  OH   . TYR C 3 66  ? 12.136  -16.508 -16.937 1.00 22.43  ? 71  TYR T OH   1 
ATOM   3650 N  N    . LEU C 3 67  ? 5.161   -15.356 -21.524 1.00 32.63  ? 72  LEU T N    1 
ATOM   3651 C  CA   . LEU C 3 67  ? 3.840   -15.668 -22.063 1.00 32.17  ? 72  LEU T CA   1 
ATOM   3652 C  C    . LEU C 3 67  ? 3.724   -17.173 -22.258 1.00 25.20  ? 72  LEU T C    1 
ATOM   3653 O  O    . LEU C 3 67  ? 4.691   -17.858 -22.580 1.00 21.61  ? 72  LEU T O    1 
ATOM   3654 C  CB   . LEU C 3 67  ? 3.569   -14.918 -23.369 1.00 38.24  ? 72  LEU T CB   1 
ATOM   3655 C  CG   . LEU C 3 67  ? 2.177   -15.159 -23.974 1.00 48.44  ? 72  LEU T CG   1 
ATOM   3656 C  CD1  . LEU C 3 67  ? 1.085   -14.539 -23.121 1.00 46.37  ? 72  LEU T CD1  1 
ATOM   3657 C  CD2  . LEU C 3 67  ? 2.065   -14.626 -25.409 1.00 51.11  ? 72  LEU T CD2  1 
ATOM   3658 N  N    . ALA C 3 68  ? 2.527   -17.679 -21.994 1.00 23.36  ? 73  ALA T N    1 
ATOM   3659 C  CA   . ALA C 3 68  ? 2.250   -19.098 -22.145 1.00 23.18  ? 73  ALA T CA   1 
ATOM   3660 C  C    . ALA C 3 68  ? 1.093   -19.264 -23.114 1.00 22.03  ? 73  ALA T C    1 
ATOM   3661 O  O    . ALA C 3 68  ? 0.304   -18.335 -23.283 1.00 23.30  ? 73  ALA T O    1 
ATOM   3662 C  CB   . ALA C 3 68  ? 1.926   -19.733 -20.815 1.00 21.84  ? 73  ALA T CB   1 
ATOM   3663 N  N    . ARG C 3 69  ? 0.988   -20.450 -23.717 1.00 20.41  ? 74  ARG T N    1 
ATOM   3664 C  CA   . ARG C 3 69  ? -0.218  -20.766 -24.446 1.00 22.43  ? 74  ARG T CA   1 
ATOM   3665 C  C    . ARG C 3 69  ? -0.464  -22.264 -24.399 1.00 22.83  ? 74  ARG T C    1 
ATOM   3666 O  O    . ARG C 3 69  ? 0.471   -23.046 -24.270 1.00 25.17  ? 74  ARG T O    1 
ATOM   3667 C  CB   . ARG C 3 69  ? -0.127  -20.212 -25.874 1.00 23.71  ? 74  ARG T CB   1 
ATOM   3668 C  CG   . ARG C 3 69  ? 1.053   -20.732 -26.683 1.00 22.68  ? 74  ARG T CG   1 
ATOM   3669 C  CD   . ARG C 3 69  ? 1.188   -20.021 -28.021 1.00 19.73  ? 74  ARG T CD   1 
ATOM   3670 N  NE   . ARG C 3 69  ? 2.363   -20.491 -28.718 1.00 16.39  ? 74  ARG T NE   1 
ATOM   3671 C  CZ   . ARG C 3 69  ? 2.866   -19.931 -29.799 1.00 15.97  ? 74  ARG T CZ   1 
ATOM   3672 N  NH1  . ARG C 3 69  ? 2.334   -18.829 -30.278 1.00 16.30  ? 74  ARG T NH1  1 
ATOM   3673 N  NH2  . ARG C 3 69  ? 3.890   -20.490 -30.420 1.00 16.56  ? 74  ARG T NH2  1 
ATOM   3674 N  N    . VAL C 3 70  ? -1.745  -22.624 -24.498 1.00 23.70  ? 75  VAL T N    1 
ATOM   3675 C  CA   . VAL C 3 70  ? -2.218  -23.987 -24.331 1.00 24.23  ? 75  VAL T CA   1 
ATOM   3676 C  C    . VAL C 3 70  ? -2.800  -24.451 -25.665 1.00 22.73  ? 75  VAL T C    1 
ATOM   3677 O  O    . VAL C 3 70  ? -3.726  -23.812 -26.172 1.00 21.35  ? 75  VAL T O    1 
ATOM   3678 C  CB   . VAL C 3 70  ? -3.272  -24.059 -23.200 1.00 25.45  ? 75  VAL T CB   1 
ATOM   3679 C  CG1  . VAL C 3 70  ? -3.860  -25.453 -23.028 1.00 25.62  ? 75  VAL T CG1  1 
ATOM   3680 C  CG2  . VAL C 3 70  ? -2.708  -23.574 -21.869 1.00 26.67  ? 75  VAL T CG2  1 
ATOM   3681 N  N    . PHE C 3 71  ? -2.277  -25.580 -26.174 1.00 21.83  ? 76  PHE T N    1 
ATOM   3682 C  CA   . PHE C 3 71  ? -2.699  -26.160 -27.440 1.00 24.31  ? 76  PHE T CA   1 
ATOM   3683 C  C    . PHE C 3 71  ? -3.660  -27.323 -27.225 1.00 23.20  ? 76  PHE T C    1 
ATOM   3684 O  O    . PHE C 3 71  ? -3.413  -28.172 -26.383 1.00 21.01  ? 76  PHE T O    1 
ATOM   3685 C  CB   . PHE C 3 71  ? -1.513  -26.701 -28.242 1.00 27.56  ? 76  PHE T CB   1 
ATOM   3686 C  CG   . PHE C 3 71  ? -0.657  -25.645 -28.883 1.00 33.76  ? 76  PHE T CG   1 
ATOM   3687 C  CD1  . PHE C 3 71  ? -1.108  -24.936 -29.980 1.00 37.50  ? 76  PHE T CD1  1 
ATOM   3688 C  CD2  . PHE C 3 71  ? 0.593   -25.340 -28.374 1.00 39.91  ? 76  PHE T CD2  1 
ATOM   3689 C  CE1  . PHE C 3 71  ? -0.331  -23.936 -30.547 1.00 40.15  ? 76  PHE T CE1  1 
ATOM   3690 C  CE2  . PHE C 3 71  ? 1.375   -24.358 -28.961 1.00 41.34  ? 76  PHE T CE2  1 
ATOM   3691 C  CZ   . PHE C 3 71  ? 0.915   -23.658 -30.044 1.00 38.29  ? 76  PHE T CZ   1 
ATOM   3692 N  N    . SER C 3 72  ? -4.711  -27.375 -28.056 1.00 24.35  ? 77  SER T N    1 
ATOM   3693 C  CA   . SER C 3 72  ? -5.705  -28.442 -28.029 1.00 24.39  ? 77  SER T CA   1 
ATOM   3694 C  C    . SER C 3 72  ? -5.535  -29.356 -29.239 1.00 25.19  ? 77  SER T C    1 
ATOM   3695 O  O    . SER C 3 72  ? -5.542  -28.906 -30.377 1.00 26.32  ? 77  SER T O    1 
ATOM   3696 C  CB   . SER C 3 72  ? -7.092  -27.881 -28.017 1.00 23.32  ? 77  SER T CB   1 
ATOM   3697 O  OG   . SER C 3 72  ? -7.379  -27.286 -26.772 1.00 24.64  ? 77  SER T OG   1 
ATOM   3698 N  N    . TYR C 3 73  ? -5.430  -30.646 -28.974 1.00 27.44  ? 78  TYR T N    1 
ATOM   3699 C  CA   . TYR C 3 73  ? -5.347  -31.645 -30.020 1.00 31.42  ? 78  TYR T CA   1 
ATOM   3700 C  C    . TYR C 3 73  ? -6.416  -32.719 -29.809 1.00 35.94  ? 78  TYR T C    1 
ATOM   3701 O  O    . TYR C 3 73  ? -6.767  -33.092 -28.687 1.00 31.05  ? 78  TYR T O    1 
ATOM   3702 C  CB   . TYR C 3 73  ? -3.979  -32.321 -29.997 1.00 30.53  ? 78  TYR T CB   1 
ATOM   3703 C  CG   . TYR C 3 73  ? -2.798  -31.394 -30.206 1.00 29.86  ? 78  TYR T CG   1 
ATOM   3704 C  CD1  . TYR C 3 73  ? -2.425  -30.992 -31.478 1.00 30.54  ? 78  TYR T CD1  1 
ATOM   3705 C  CD2  . TYR C 3 73  ? -2.044  -30.949 -29.127 1.00 30.17  ? 78  TYR T CD2  1 
ATOM   3706 C  CE1  . TYR C 3 73  ? -1.320  -30.187 -31.674 1.00 35.52  ? 78  TYR T CE1  1 
ATOM   3707 C  CE2  . TYR C 3 73  ? -0.935  -30.150 -29.309 1.00 29.84  ? 78  TYR T CE2  1 
ATOM   3708 C  CZ   . TYR C 3 73  ? -0.577  -29.768 -30.584 1.00 34.15  ? 78  TYR T CZ   1 
ATOM   3709 O  OH   . TYR C 3 73  ? 0.491   -28.955 -30.800 1.00 48.66  ? 78  TYR T OH   1 
ATOM   3710 N  N    . PRO C 3 74  ? -6.984  -33.255 -30.905 1.00 43.31  ? 79  PRO T N    1 
ATOM   3711 C  CA   . PRO C 3 74  ? -7.885  -34.397 -30.801 1.00 41.89  ? 79  PRO T CA   1 
ATOM   3712 C  C    . PRO C 3 74  ? -7.059  -35.644 -30.544 1.00 40.15  ? 79  PRO T C    1 
ATOM   3713 O  O    . PRO C 3 74  ? -5.974  -35.764 -31.091 1.00 34.67  ? 79  PRO T O    1 
ATOM   3714 C  CB   . PRO C 3 74  ? -8.572  -34.448 -32.167 1.00 45.95  ? 79  PRO T CB   1 
ATOM   3715 C  CG   . PRO C 3 74  ? -7.626  -33.736 -33.123 1.00 46.18  ? 79  PRO T CG   1 
ATOM   3716 C  CD   . PRO C 3 74  ? -6.803  -32.774 -32.284 1.00 45.10  ? 79  PRO T CD   1 
ATOM   3717 N  N    . ALA C 3 75  ? -7.595  -36.564 -29.732 1.00 45.00  ? 80  ALA T N    1 
ATOM   3718 C  CA   . ALA C 3 75  ? -6.900  -37.784 -29.354 1.00 41.44  ? 80  ALA T CA   1 
ATOM   3719 C  C    . ALA C 3 75  ? -6.673  -38.711 -30.562 1.00 41.03  ? 80  ALA T C    1 
ATOM   3720 O  O    . ALA C 3 75  ? -7.615  -38.877 -31.370 1.00 43.20  ? 80  ALA T O    1 
ATOM   3721 C  CB   . ALA C 3 75  ? -7.687  -38.451 -28.266 1.00 40.78  ? 80  ALA T CB   1 
ATOM   3722 N  N    . GLU D 4 1   ? -2.905  -25.304 -38.299 1.00 36.34  ? 91  GLU U N    1 
ATOM   3723 C  CA   . GLU D 4 1   ? -2.484  -24.849 -36.937 1.00 35.32  ? 91  GLU U CA   1 
ATOM   3724 C  C    . GLU D 4 1   ? -3.510  -25.303 -35.889 1.00 33.72  ? 91  GLU U C    1 
ATOM   3725 O  O    . GLU D 4 1   ? -4.729  -25.242 -36.088 1.00 29.99  ? 91  GLU U O    1 
ATOM   3726 C  CB   . GLU D 4 1   ? -2.247  -23.336 -36.909 1.00 34.59  ? 91  GLU U CB   1 
ATOM   3727 C  CG   . GLU D 4 1   ? -0.945  -22.921 -37.586 1.00 38.23  ? 91  GLU U CG   1 
ATOM   3728 C  CD   . GLU D 4 1   ? -0.574  -21.440 -37.526 1.00 37.54  ? 91  GLU U CD   1 
ATOM   3729 O  OE1  . GLU D 4 1   ? -1.443  -20.615 -37.197 1.00 41.64  ? 91  GLU U OE1  1 
ATOM   3730 O  OE2  . GLU D 4 1   ? 0.599   -21.118 -37.775 1.00 33.93  ? 91  GLU U OE2  1 
ATOM   3731 N  N    . PRO D 4 2   ? -3.054  -25.824 -34.728 1.00 32.75  ? 92  PRO U N    1 
ATOM   3732 C  CA   . PRO D 4 2   ? -3.988  -26.240 -33.683 1.00 31.69  ? 92  PRO U CA   1 
ATOM   3733 C  C    . PRO D 4 2   ? -4.674  -25.041 -33.033 1.00 29.93  ? 92  PRO U C    1 
ATOM   3734 O  O    . PRO D 4 2   ? -4.137  -23.940 -33.073 1.00 33.13  ? 92  PRO U O    1 
ATOM   3735 C  CB   . PRO D 4 2   ? -3.098  -26.994 -32.693 1.00 32.42  ? 92  PRO U CB   1 
ATOM   3736 C  CG   . PRO D 4 2   ? -1.735  -26.360 -32.887 1.00 35.76  ? 92  PRO U CG   1 
ATOM   3737 C  CD   . PRO D 4 2   ? -1.649  -26.050 -34.369 1.00 32.71  ? 92  PRO U CD   1 
ATOM   3738 N  N    . LEU D 4 3   ? -5.876  -25.266 -32.480 1.00 27.37  ? 93  LEU U N    1 
ATOM   3739 C  CA   . LEU D 4 3   ? -6.537  -24.279 -31.646 1.00 27.61  ? 93  LEU U CA   1 
ATOM   3740 C  C    . LEU D 4 3   ? -5.700  -24.055 -30.389 1.00 26.03  ? 93  LEU U C    1 
ATOM   3741 O  O    . LEU D 4 3   ? -5.172  -25.000 -29.775 1.00 22.54  ? 93  LEU U O    1 
ATOM   3742 C  CB   . LEU D 4 3   ? -7.949  -24.753 -31.293 1.00 32.15  ? 93  LEU U CB   1 
ATOM   3743 C  CG   . LEU D 4 3   ? -9.049  -24.391 -32.304 1.00 35.12  ? 93  LEU U CG   1 
ATOM   3744 C  CD1  . LEU D 4 3   ? -8.757  -24.979 -33.697 1.00 34.20  ? 93  LEU U CD1  1 
ATOM   3745 C  CD2  . LEU D 4 3   ? -10.435 -24.830 -31.805 1.00 31.07  ? 93  LEU U CD2  1 
ATOM   3746 N  N    . TYR D 4 4   ? -5.539  -22.776 -30.037 1.00 22.01  ? 94  TYR U N    1 
ATOM   3747 C  CA   . TYR D 4 4   ? -4.763  -22.458 -28.861 1.00 21.56  ? 94  TYR U CA   1 
ATOM   3748 C  C    . TYR D 4 4   ? -5.326  -21.219 -28.197 1.00 19.37  ? 94  TYR U C    1 
ATOM   3749 O  O    . TYR D 4 4   ? -6.012  -20.429 -28.808 1.00 17.81  ? 94  TYR U O    1 
ATOM   3750 C  CB   . TYR D 4 4   ? -3.288  -22.291 -29.243 1.00 21.26  ? 94  TYR U CB   1 
ATOM   3751 C  CG   . TYR D 4 4   ? -2.990  -21.058 -30.082 1.00 20.32  ? 94  TYR U CG   1 
ATOM   3752 C  CD1  . TYR D 4 4   ? -2.576  -19.878 -29.487 1.00 21.46  ? 94  TYR U CD1  1 
ATOM   3753 C  CD2  . TYR D 4 4   ? -3.113  -21.074 -31.454 1.00 19.99  ? 94  TYR U CD2  1 
ATOM   3754 C  CE1  . TYR D 4 4   ? -2.260  -18.753 -30.230 1.00 21.82  ? 94  TYR U CE1  1 
ATOM   3755 C  CE2  . TYR D 4 4   ? -2.851  -19.941 -32.207 1.00 22.59  ? 94  TYR U CE2  1 
ATOM   3756 C  CZ   . TYR D 4 4   ? -2.399  -18.784 -31.596 1.00 23.67  ? 94  TYR U CZ   1 
ATOM   3757 O  OH   . TYR D 4 4   ? -2.084  -17.669 -32.303 1.00 26.48  ? 94  TYR U OH   1 
ATOM   3758 N  N    . GLU D 4 5   ? -4.940  -21.023 -26.950 1.00 21.23  ? 95  GLU U N    1 
ATOM   3759 C  CA   . GLU D 4 5   ? -5.320  -19.810 -26.256 1.00 24.83  ? 95  GLU U CA   1 
ATOM   3760 C  C    . GLU D 4 5   ? -4.071  -19.267 -25.569 1.00 24.57  ? 95  GLU U C    1 
ATOM   3761 O  O    . GLU D 4 5   ? -3.225  -20.048 -25.127 1.00 26.82  ? 95  GLU U O    1 
ATOM   3762 C  CB   . GLU D 4 5   ? -6.472  -20.124 -25.299 1.00 27.66  ? 95  GLU U CB   1 
ATOM   3763 C  CG   . GLU D 4 5   ? -7.050  -18.925 -24.578 1.00 31.32  ? 95  GLU U CG   1 
ATOM   3764 C  CD   . GLU D 4 5   ? -7.531  -17.848 -25.515 1.00 33.47  ? 95  GLU U CD   1 
ATOM   3765 O  OE1  . GLU D 4 5   ? -8.315  -18.175 -26.408 1.00 39.81  ? 95  GLU U OE1  1 
ATOM   3766 O  OE2  . GLU D 4 5   ? -7.100  -16.716 -25.352 1.00 39.23  ? 95  GLU U OE2  1 
ATOM   3767 N  N    . ASN D 4 6   ? -3.987  -17.934 -25.492 1.00 21.80  ? 96  ASN U N    1 
ATOM   3768 C  CA   . ASN D 4 6   ? -2.871  -17.264 -24.856 1.00 21.71  ? 96  ASN U CA   1 
ATOM   3769 C  C    . ASN D 4 6   ? -3.189  -17.000 -23.386 1.00 21.84  ? 96  ASN U C    1 
ATOM   3770 O  O    . ASN D 4 6   ? -4.338  -16.717 -23.020 1.00 22.99  ? 96  ASN U O    1 
ATOM   3771 C  CB   . ASN D 4 6   ? -2.511  -15.967 -25.590 1.00 20.85  ? 96  ASN U CB   1 
ATOM   3772 C  CG   . ASN D 4 6   ? -1.983  -16.202 -26.985 1.00 21.23  ? 96  ASN U CG   1 
ATOM   3773 O  OD1  . ASN D 4 6   ? -2.434  -15.578 -27.934 1.00 23.17  ? 96  ASN U OD1  1 
ATOM   3774 N  ND2  . ASN D 4 6   ? -1.010  -17.085 -27.131 1.00 23.32  ? 96  ASN U ND2  1 
ATOM   3775 N  N    . SER D 4 7   ? -2.147  -17.073 -22.549 1.00 20.32  ? 97  SER U N    1 
ATOM   3776 C  CA   . SER D 4 7   ? -2.281  -16.768 -21.138 1.00 19.66  ? 97  SER U CA   1 
ATOM   3777 C  C    . SER D 4 7   ? -2.090  -15.276 -20.921 1.00 21.33  ? 97  SER U C    1 
ATOM   3778 O  O    . SER D 4 7   ? -1.643  -14.567 -21.811 1.00 21.43  ? 97  SER U O    1 
ATOM   3779 C  CB   . SER D 4 7   ? -1.275  -17.508 -20.355 1.00 19.84  ? 97  SER U CB   1 
ATOM   3780 O  OG   . SER D 4 7   ? -0.007  -16.891 -20.511 1.00 19.32  ? 97  SER U OG   1 
ATOM   3781 N  N    . PRO D 4 8   ? -2.371  -14.745 -19.719 1.00 23.01  ? 98  PRO U N    1 
ATOM   3782 C  CA   . PRO D 4 8   ? -1.901  -13.410 -19.359 1.00 25.97  ? 98  PRO U CA   1 
ATOM   3783 C  C    . PRO D 4 8   ? -0.383  -13.447 -19.203 1.00 27.07  ? 98  PRO U C    1 
ATOM   3784 O  O    . PRO D 4 8   ? 0.186   -14.506 -18.930 1.00 30.90  ? 98  PRO U O    1 
ATOM   3785 C  CB   . PRO D 4 8   ? -2.603  -13.080 -18.026 1.00 25.60  ? 98  PRO U CB   1 
ATOM   3786 C  CG   . PRO D 4 8   ? -3.630  -14.185 -17.824 1.00 24.60  ? 98  PRO U CG   1 
ATOM   3787 C  CD   . PRO D 4 8   ? -3.165  -15.369 -18.654 1.00 24.40  ? 98  PRO U CD   1 
ATOM   3788 N  N    . GLU D 4 9   ? 0.268   -12.298 -19.383 1.00 25.82  ? 99  GLU U N    1 
ATOM   3789 C  CA   . GLU D 4 9   ? 1.693   -12.189 -19.125 1.00 27.55  ? 99  GLU U CA   1 
ATOM   3790 C  C    . GLU D 4 9   ? 1.965   -12.459 -17.657 1.00 24.15  ? 99  GLU U C    1 
ATOM   3791 O  O    . GLU D 4 9   ? 1.064   -12.352 -16.840 1.00 24.64  ? 99  GLU U O    1 
ATOM   3792 C  CB   . GLU D 4 9   ? 2.173   -10.783 -19.459 1.00 34.43  ? 99  GLU U CB   1 
ATOM   3793 C  CG   . GLU D 4 9   ? 2.151   -10.487 -20.951 1.00 41.62  ? 99  GLU U CG   1 
ATOM   3794 C  CD   . GLU D 4 9   ? 2.409   -9.034  -21.291 1.00 46.91  ? 99  GLU U CD   1 
ATOM   3795 O  OE1  . GLU D 4 9   ? 2.595   -8.231  -20.337 1.00 50.30  ? 99  GLU U OE1  1 
ATOM   3796 O  OE2  . GLU D 4 9   ? 2.423   -8.717  -22.495 1.00 54.19  ? 99  GLU U OE2  1 
ATOM   3797 N  N    . PHE D 4 10  ? 3.206   -12.787 -17.320 1.00 24.58  ? 100 PHE U N    1 
ATOM   3798 C  CA   . PHE D 4 10  ? 3.541   -13.061 -15.930 1.00 24.68  ? 100 PHE U CA   1 
ATOM   3799 C  C    . PHE D 4 10  ? 4.999   -12.723 -15.625 1.00 24.48  ? 100 PHE U C    1 
ATOM   3800 O  O    . PHE D 4 10  ? 5.944   -13.274 -16.207 1.00 28.88  ? 100 PHE U O    1 
ATOM   3801 C  CB   . PHE D 4 10  ? 3.243   -14.526 -15.623 1.00 25.63  ? 100 PHE U CB   1 
ATOM   3802 C  CG   . PHE D 4 10  ? 3.518   -14.976 -14.214 1.00 24.91  ? 100 PHE U CG   1 
ATOM   3803 C  CD1  . PHE D 4 10  ? 2.690   -14.605 -13.179 1.00 27.03  ? 100 PHE U CD1  1 
ATOM   3804 C  CD2  . PHE D 4 10  ? 4.589   -15.801 -13.933 1.00 26.98  ? 100 PHE U CD2  1 
ATOM   3805 C  CE1  . PHE D 4 10  ? 2.942   -15.027 -11.884 1.00 27.43  ? 100 PHE U CE1  1 
ATOM   3806 C  CE2  . PHE D 4 10  ? 4.841   -16.225 -12.639 1.00 28.15  ? 100 PHE U CE2  1 
ATOM   3807 C  CZ   . PHE D 4 10  ? 3.999   -15.855 -11.624 1.00 27.57  ? 100 PHE U CZ   1 
ATOM   3808 N  N    . THR D 4 11  ? 5.180   -11.821 -14.671 1.00 23.20  ? 101 THR U N    1 
ATOM   3809 C  CA   . THR D 4 11  ? 6.513   -11.456 -14.230 1.00 24.42  ? 101 THR U CA   1 
ATOM   3810 C  C    . THR D 4 11  ? 6.705   -11.993 -12.817 1.00 24.83  ? 101 THR U C    1 
ATOM   3811 O  O    . THR D 4 11  ? 6.245   -11.385 -11.858 1.00 25.54  ? 101 THR U O    1 
ATOM   3812 C  CB   . THR D 4 11  ? 6.749   -9.945  -14.307 1.00 22.26  ? 101 THR U CB   1 
ATOM   3813 O  OG1  . THR D 4 11  ? 6.362   -9.534  -15.610 1.00 24.01  ? 101 THR U OG1  1 
ATOM   3814 C  CG2  . THR D 4 11  ? 8.190   -9.568  -14.066 1.00 22.84  ? 101 THR U CG2  1 
ATOM   3815 N  N    . PRO D 4 12  ? 7.395   -13.140 -12.651 1.00 24.86  ? 102 PRO U N    1 
ATOM   3816 C  CA   . PRO D 4 12  ? 7.499   -13.779 -11.341 1.00 24.79  ? 102 PRO U CA   1 
ATOM   3817 C  C    . PRO D 4 12  ? 7.857   -12.817 -10.210 1.00 28.13  ? 102 PRO U C    1 
ATOM   3818 O  O    . PRO D 4 12  ? 7.170   -12.775 -9.193  1.00 27.05  ? 102 PRO U O    1 
ATOM   3819 C  CB   . PRO D 4 12  ? 8.614   -14.800 -11.556 1.00 25.35  ? 102 PRO U CB   1 
ATOM   3820 C  CG   . PRO D 4 12  ? 8.505   -15.156 -13.040 1.00 26.36  ? 102 PRO U CG   1 
ATOM   3821 C  CD   . PRO D 4 12  ? 8.067   -13.884 -13.726 1.00 24.41  ? 102 PRO U CD   1 
ATOM   3822 N  N    . TYR D 4 13  ? 8.910   -12.007 -10.411 1.00 30.53  ? 103 TYR U N    1 
ATOM   3823 C  CA   . TYR D 4 13  ? 9.472   -11.210 -9.329  1.00 27.72  ? 103 TYR U CA   1 
ATOM   3824 C  C    . TYR D 4 13  ? 8.389   -10.290 -8.777  1.00 26.54  ? 103 TYR U C    1 
ATOM   3825 O  O    . TYR D 4 13  ? 8.386   -10.017 -7.589  1.00 28.33  ? 103 TYR U O    1 
ATOM   3826 C  CB   . TYR D 4 13  ? 10.702  -10.457 -9.836  1.00 27.09  ? 103 TYR U CB   1 
ATOM   3827 C  CG   . TYR D 4 13  ? 11.578  -9.779  -8.789  1.00 27.47  ? 103 TYR U CG   1 
ATOM   3828 C  CD1  . TYR D 4 13  ? 12.624  -10.460 -8.172  1.00 27.12  ? 103 TYR U CD1  1 
ATOM   3829 C  CD2  . TYR D 4 13  ? 11.404  -8.436  -8.467  1.00 26.63  ? 103 TYR U CD2  1 
ATOM   3830 C  CE1  . TYR D 4 13  ? 13.459  -9.835  -7.265  1.00 26.55  ? 103 TYR U CE1  1 
ATOM   3831 C  CE2  . TYR D 4 13  ? 12.223  -7.800  -7.547  1.00 26.32  ? 103 TYR U CE2  1 
ATOM   3832 C  CZ   . TYR D 4 13  ? 13.250  -8.503  -6.944  1.00 28.66  ? 103 TYR U CZ   1 
ATOM   3833 O  OH   . TYR D 4 13  ? 14.035  -7.894  -6.003  1.00 30.84  ? 103 TYR U OH   1 
ATOM   3834 N  N    . LEU D 4 14  ? 7.457   -9.857  -9.631  1.00 25.86  ? 104 LEU U N    1 
ATOM   3835 C  CA   . LEU D 4 14  ? 6.457   -8.873  -9.258  1.00 25.22  ? 104 LEU U CA   1 
ATOM   3836 C  C    . LEU D 4 14  ? 5.135   -9.514  -8.845  1.00 26.64  ? 104 LEU U C    1 
ATOM   3837 O  O    . LEU D 4 14  ? 4.333   -8.812  -8.215  1.00 26.37  ? 104 LEU U O    1 
ATOM   3838 C  CB   . LEU D 4 14  ? 6.179   -7.951  -10.449 1.00 25.22  ? 104 LEU U CB   1 
ATOM   3839 C  CG   . LEU D 4 14  ? 7.323   -7.082  -10.948 1.00 26.99  ? 104 LEU U CG   1 
ATOM   3840 C  CD1  . LEU D 4 14  ? 6.795   -6.109  -11.992 1.00 26.05  ? 104 LEU U CD1  1 
ATOM   3841 C  CD2  . LEU D 4 14  ? 8.027   -6.326  -9.815  1.00 27.57  ? 104 LEU U CD2  1 
ATOM   3842 N  N    . GLU D 4 15  ? 4.882   -10.780 -9.260  1.00 25.10  ? 105 GLU U N    1 
ATOM   3843 C  CA   . GLU D 4 15  ? 3.554   -11.366 -9.151  1.00 26.14  ? 105 GLU U CA   1 
ATOM   3844 C  C    . GLU D 4 15  ? 3.501   -12.658 -8.332  1.00 25.80  ? 105 GLU U C    1 
ATOM   3845 O  O    . GLU D 4 15  ? 2.431   -13.105 -7.943  1.00 25.56  ? 105 GLU U O    1 
ATOM   3846 C  CB   . GLU D 4 15  ? 2.978   -11.601 -10.544 1.00 29.82  ? 105 GLU U CB   1 
ATOM   3847 C  CG   . GLU D 4 15  ? 2.586   -10.303 -11.236 1.00 34.01  ? 105 GLU U CG   1 
ATOM   3848 C  CD   . GLU D 4 15  ? 2.137   -10.450 -12.677 1.00 34.13  ? 105 GLU U CD   1 
ATOM   3849 O  OE1  . GLU D 4 15  ? 2.960   -10.188 -13.560 1.00 35.84  ? 105 GLU U OE1  1 
ATOM   3850 O  OE2  . GLU D 4 15  ? 0.972   -10.818 -12.908 1.00 36.85  ? 105 GLU U OE2  1 
ATOM   3851 N  N    . THR D 4 16  ? 4.619   -13.309 -8.056  1.00 26.03  ? 106 THR U N    1 
ATOM   3852 C  CA   . THR D 4 16  ? 4.499   -14.515 -7.263  1.00 24.89  ? 106 THR U CA   1 
ATOM   3853 C  C    . THR D 4 16  ? 4.038   -14.104 -5.872  1.00 25.97  ? 106 THR U C    1 
ATOM   3854 O  O    . THR D 4 16  ? 4.534   -13.107 -5.336  1.00 27.96  ? 106 THR U O    1 
ATOM   3855 C  CB   . THR D 4 16  ? 5.807   -15.303 -7.231  1.00 23.62  ? 106 THR U CB   1 
ATOM   3856 O  OG1  . THR D 4 16  ? 5.501   -16.620 -6.774  1.00 21.59  ? 106 THR U OG1  1 
ATOM   3857 C  CG2  . THR D 4 16  ? 6.858   -14.659 -6.357  1.00 22.96  ? 106 THR U CG2  1 
ATOM   3858 N  N    . ASN D 4 17  ? 3.103   -14.882 -5.304  1.00 26.27  ? 107 ASN U N    1 
ATOM   3859 C  CA   . ASN D 4 17  ? 2.647   -14.660 -3.940  1.00 25.50  ? 107 ASN U CA   1 
ATOM   3860 C  C    . ASN D 4 17  ? 3.784   -14.981 -2.985  1.00 25.29  ? 107 ASN U C    1 
ATOM   3861 O  O    . ASN D 4 17  ? 4.555   -15.915 -3.226  1.00 24.44  ? 107 ASN U O    1 
ATOM   3862 C  CB   . ASN D 4 17  ? 1.439   -15.511 -3.563  1.00 27.21  ? 107 ASN U CB   1 
ATOM   3863 C  CG   . ASN D 4 17  ? 0.240   -15.251 -4.443  1.00 31.38  ? 107 ASN U CG   1 
ATOM   3864 O  OD1  . ASN D 4 17  ? -0.295  -16.163 -5.062  1.00 35.45  ? 107 ASN U OD1  1 
ATOM   3865 N  ND2  . ASN D 4 17  ? -0.184  -14.005 -4.522  1.00 36.39  ? 107 ASN U ND2  1 
ATOM   3866 N  N    . LEU D 4 18  ? 3.883   -14.187 -1.913  1.00 24.87  ? 108 LEU U N    1 
ATOM   3867 C  CA   . LEU D 4 18  ? 4.783   -14.489 -0.811  1.00 23.99  ? 108 LEU U CA   1 
ATOM   3868 C  C    . LEU D 4 18  ? 4.128   -15.528 0.078   1.00 21.63  ? 108 LEU U C    1 
ATOM   3869 O  O    . LEU D 4 18  ? 2.948   -15.437 0.351   1.00 23.52  ? 108 LEU U O    1 
ATOM   3870 C  CB   . LEU D 4 18  ? 5.060   -13.209 -0.025  1.00 25.17  ? 108 LEU U CB   1 
ATOM   3871 C  CG   . LEU D 4 18  ? 5.708   -12.087 -0.839  1.00 27.27  ? 108 LEU U CG   1 
ATOM   3872 C  CD1  . LEU D 4 18  ? 5.713   -10.772 -0.058  1.00 29.06  ? 108 LEU U CD1  1 
ATOM   3873 C  CD2  . LEU D 4 18  ? 7.113   -12.463 -1.258  1.00 25.37  ? 108 LEU U CD2  1 
ATOM   3874 N  N    . GLY D 4 19  ? 4.900   -16.516 0.505   1.00 23.42  ? 109 GLY U N    1 
ATOM   3875 C  CA   . GLY D 4 19  ? 4.372   -17.613 1.305   1.00 26.15  ? 109 GLY U CA   1 
ATOM   3876 C  C    . GLY D 4 19  ? 4.162   -17.221 2.765   1.00 24.80  ? 109 GLY U C    1 
ATOM   3877 O  O    . GLY D 4 19  ? 4.526   -16.127 3.175   1.00 28.09  ? 109 GLY U O    1 
ATOM   3878 N  N    . GLN D 4 20  ? 3.638   -18.150 3.555   1.00 23.04  ? 110 GLN U N    1 
ATOM   3879 C  CA   . GLN D 4 20  ? 3.382   -17.872 4.948   1.00 24.16  ? 110 GLN U CA   1 
ATOM   3880 C  C    . GLN D 4 20  ? 4.684   -17.927 5.737   1.00 23.76  ? 110 GLN U C    1 
ATOM   3881 O  O    . GLN D 4 20  ? 5.330   -18.975 5.811   1.00 23.80  ? 110 GLN U O    1 
ATOM   3882 C  CB   . GLN D 4 20  ? 2.393   -18.869 5.545   1.00 26.10  ? 110 GLN U CB   1 
ATOM   3883 C  CG   . GLN D 4 20  ? 1.996   -18.477 6.954   1.00 28.30  ? 110 GLN U CG   1 
ATOM   3884 C  CD   . GLN D 4 20  ? 0.926   -19.360 7.523   1.00 31.89  ? 110 GLN U CD   1 
ATOM   3885 O  OE1  . GLN D 4 20  ? 0.910   -20.553 7.259   1.00 31.93  ? 110 GLN U OE1  1 
ATOM   3886 N  NE2  . GLN D 4 20  ? 0.041   -18.769 8.315   1.00 37.45  ? 110 GLN U NE2  1 
ATOM   3887 N  N    . PRO D 4 21  ? 5.075   -16.819 6.402   1.00 24.03  ? 111 PRO U N    1 
ATOM   3888 C  CA   . PRO D 4 21  ? 6.270   -16.820 7.249   1.00 23.36  ? 111 PRO U CA   1 
ATOM   3889 C  C    . PRO D 4 21  ? 5.984   -17.593 8.525   1.00 26.11  ? 111 PRO U C    1 
ATOM   3890 O  O    . PRO D 4 21  ? 4.818   -17.801 8.877   1.00 27.28  ? 111 PRO U O    1 
ATOM   3891 C  CB   . PRO D 4 21  ? 6.545   -15.342 7.509   1.00 22.87  ? 111 PRO U CB   1 
ATOM   3892 C  CG   . PRO D 4 21  ? 5.178   -14.694 7.385   1.00 24.84  ? 111 PRO U CG   1 
ATOM   3893 C  CD   . PRO D 4 21  ? 4.401   -15.513 6.367   1.00 23.96  ? 111 PRO U CD   1 
ATOM   3894 N  N    . THR D 4 22  ? 7.054   -18.120 9.121   1.00 25.62  ? 112 THR U N    1 
ATOM   3895 C  CA   . THR D 4 22  ? 7.010   -18.616 10.479  1.00 29.91  ? 112 THR U CA   1 
ATOM   3896 C  C    . THR D 4 22  ? 8.104   -17.936 11.301  1.00 27.82  ? 112 THR U C    1 
ATOM   3897 O  O    . THR D 4 22  ? 9.106   -17.458 10.771  1.00 28.34  ? 112 THR U O    1 
ATOM   3898 C  CB   . THR D 4 22  ? 7.093   -20.149 10.541  1.00 32.87  ? 112 THR U CB   1 
ATOM   3899 O  OG1  . THR D 4 22  ? 8.328   -20.572 9.976   1.00 34.11  ? 112 THR U OG1  1 
ATOM   3900 C  CG2  . THR D 4 22  ? 5.933   -20.814 9.830   1.00 36.05  ? 112 THR U CG2  1 
ATOM   3901 N  N    . ILE D 4 23  ? 7.852   -17.885 12.607  1.00 27.04  ? 113 ILE U N    1 
ATOM   3902 C  CA   . ILE D 4 23  ? 8.785   -17.409 13.611  1.00 27.37  ? 113 ILE U CA   1 
ATOM   3903 C  C    . ILE D 4 23  ? 9.644   -18.587 14.070  1.00 27.86  ? 113 ILE U C    1 
ATOM   3904 O  O    . ILE D 4 23  ? 9.143   -19.624 14.500  1.00 26.93  ? 113 ILE U O    1 
ATOM   3905 C  CB   . ILE D 4 23  ? 7.999   -16.729 14.754  1.00 28.55  ? 113 ILE U CB   1 
ATOM   3906 C  CG1  . ILE D 4 23  ? 7.287   -15.465 14.244  1.00 28.03  ? 113 ILE U CG1  1 
ATOM   3907 C  CG2  . ILE D 4 23  ? 8.911   -16.439 15.941  1.00 29.85  ? 113 ILE U CG2  1 
ATOM   3908 C  CD1  . ILE D 4 23  ? 6.372   -14.798 15.261  1.00 28.47  ? 113 ILE U CD1  1 
ATOM   3909 N  N    . GLN D 4 24  ? 10.954  -18.424 13.926  1.00 30.79  ? 114 GLN U N    1 
ATOM   3910 C  CA   . GLN D 4 24  ? 11.927  -19.427 14.322  1.00 36.32  ? 114 GLN U CA   1 
ATOM   3911 C  C    . GLN D 4 24  ? 12.042  -19.446 15.845  1.00 39.49  ? 114 GLN U C    1 
ATOM   3912 O  O    . GLN D 4 24  ? 12.083  -20.523 16.436  1.00 42.35  ? 114 GLN U O    1 
ATOM   3913 C  CB   . GLN D 4 24  ? 13.288  -19.092 13.706  1.00 40.60  ? 114 GLN U CB   1 
ATOM   3914 C  CG   . GLN D 4 24  ? 14.172  -20.289 13.375  1.00 48.18  ? 114 GLN U CG   1 
ATOM   3915 C  CD   . GLN D 4 24  ? 15.390  -19.842 12.591  1.00 53.35  ? 114 GLN U CD   1 
ATOM   3916 O  OE1  . GLN D 4 24  ? 15.485  -20.012 11.372  1.00 59.31  ? 114 GLN U OE1  1 
ATOM   3917 N  NE2  . GLN D 4 24  ? 16.319  -19.202 13.280  1.00 51.63  ? 114 GLN U NE2  1 
ATOM   3918 N  N    . SER D 4 25  ? 12.126  -18.248 16.458  1.00 37.34  ? 115 SER U N    1 
ATOM   3919 C  CA   . SER D 4 25  ? 12.423  -18.110 17.877  1.00 38.08  ? 115 SER U CA   1 
ATOM   3920 C  C    . SER D 4 25  ? 12.211  -16.673 18.372  1.00 39.53  ? 115 SER U C    1 
ATOM   3921 O  O    . SER D 4 25  ? 12.106  -15.726 17.587  1.00 36.65  ? 115 SER U O    1 
ATOM   3922 C  CB   . SER D 4 25  ? 13.839  -18.587 18.220  1.00 33.77  ? 115 SER U CB   1 
ATOM   3923 O  OG   . SER D 4 25  ? 14.849  -17.739 17.684  1.00 29.73  ? 115 SER U OG   1 
ATOM   3924 N  N    . PHE D 4 26  ? 12.189  -16.550 19.707  1.00 38.92  ? 116 PHE U N    1 
ATOM   3925 C  CA   . PHE D 4 26  ? 12.350  -15.286 20.410  1.00 46.28  ? 116 PHE U CA   1 
ATOM   3926 C  C    . PHE D 4 26  ? 13.184  -15.514 21.683  1.00 47.10  ? 116 PHE U C    1 
ATOM   3927 O  O    . PHE D 4 26  ? 13.166  -16.594 22.272  1.00 45.06  ? 116 PHE U O    1 
ATOM   3928 C  CB   . PHE D 4 26  ? 10.976  -14.641 20.651  1.00 49.51  ? 116 PHE U CB   1 
ATOM   3929 C  CG   . PHE D 4 26  ? 9.874   -15.598 21.035  1.00 56.53  ? 116 PHE U CG   1 
ATOM   3930 C  CD1  . PHE D 4 26  ? 9.477   -15.740 22.355  1.00 62.72  ? 116 PHE U CD1  1 
ATOM   3931 C  CD2  . PHE D 4 26  ? 9.224   -16.356 20.075  1.00 62.12  ? 116 PHE U CD2  1 
ATOM   3932 C  CE1  . PHE D 4 26  ? 8.461   -16.617 22.705  1.00 64.95  ? 116 PHE U CE1  1 
ATOM   3933 C  CE2  . PHE D 4 26  ? 8.212   -17.236 20.426  1.00 64.84  ? 116 PHE U CE2  1 
ATOM   3934 C  CZ   . PHE D 4 26  ? 7.835   -17.368 21.742  1.00 66.65  ? 116 PHE U CZ   1 
ATOM   3935 N  N    . GLU D 4 27  ? 13.938  -14.496 22.108  1.00 48.51  ? 117 GLU U N    1 
ATOM   3936 C  CA   . GLU D 4 27  ? 14.798  -14.607 23.279  1.00 57.00  ? 117 GLU U CA   1 
ATOM   3937 C  C    . GLU D 4 27  ? 14.682  -13.299 24.061  1.00 56.64  ? 117 GLU U C    1 
ATOM   3938 O  O    . GLU D 4 27  ? 14.299  -12.288 23.474  1.00 52.38  ? 117 GLU U O    1 
ATOM   3939 C  CB   . GLU D 4 27  ? 16.219  -14.953 22.807  1.00 68.54  ? 117 GLU U CB   1 
ATOM   3940 C  CG   . GLU D 4 27  ? 17.249  -15.154 23.914  1.00 80.16  ? 117 GLU U CG   1 
ATOM   3941 C  CD   . GLU D 4 27  ? 17.012  -16.315 24.872  1.00 89.74  ? 117 GLU U CD   1 
ATOM   3942 O  OE1  . GLU D 4 27  ? 17.791  -17.286 24.806  1.00 84.22  ? 117 GLU U OE1  1 
ATOM   3943 O  OE2  . GLU D 4 27  ? 16.069  -16.239 25.707  1.00 95.50  ? 117 GLU U OE2  1 
ATOM   3944 N  N    . GLN D 4 28  ? 14.970  -13.325 25.376  1.00 64.73  ? 118 GLN U N    1 
ATOM   3945 C  CA   . GLN D 4 28  ? 14.936  -12.118 26.205  1.00 76.56  ? 118 GLN U CA   1 
ATOM   3946 C  C    . GLN D 4 28  ? 16.355  -11.733 26.639  1.00 78.64  ? 118 GLN U C    1 
ATOM   3947 O  O    . GLN D 4 28  ? 17.173  -12.600 26.949  1.00 74.35  ? 118 GLN U O    1 
ATOM   3948 C  CB   . GLN D 4 28  ? 13.979  -12.251 27.403  1.00 82.89  ? 118 GLN U CB   1 
ATOM   3949 C  CG   . GLN D 4 28  ? 14.026  -13.594 28.136  1.00 102.69 ? 118 GLN U CG   1 
ATOM   3950 C  CD   . GLN D 4 28  ? 15.223  -13.781 29.045  1.00 112.52 ? 118 GLN U CD   1 
ATOM   3951 O  OE1  . GLN D 4 28  ? 15.223  -13.373 30.209  1.00 100.52 ? 118 GLN U OE1  1 
ATOM   3952 N  NE2  . GLN D 4 28  ? 16.247  -14.450 28.534  1.00 113.75 ? 118 GLN U NE2  1 
ATOM   3953 N  N    . VAL D 4 29  ? 16.634  -10.416 26.626  1.00 85.00  ? 119 VAL U N    1 
ATOM   3954 C  CA   . VAL D 4 29  ? 17.851  -9.824  27.180  1.00 81.02  ? 119 VAL U CA   1 
ATOM   3955 C  C    . VAL D 4 29  ? 17.459  -8.641  28.065  1.00 76.28  ? 119 VAL U C    1 
ATOM   3956 O  O    . VAL D 4 29  ? 17.608  -7.477  27.703  1.00 59.75  ? 119 VAL U O    1 
ATOM   3957 C  CB   . VAL D 4 29  ? 18.861  -9.396  26.096  1.00 78.80  ? 119 VAL U CB   1 
ATOM   3958 C  CG1  . VAL D 4 29  ? 20.046  -10.340 26.021  1.00 84.69  ? 119 VAL U CG1  1 
ATOM   3959 C  CG2  . VAL D 4 29  ? 18.210  -9.229  24.735  1.00 80.00  ? 119 VAL U CG2  1 
ATOM   3960 N  N    . GLY D 4 30  ? 16.959  -8.963  29.256  1.00 85.36  ? 120 GLY U N    1 
ATOM   3961 C  CA   . GLY D 4 30  ? 16.446  -7.952  30.161  1.00 83.38  ? 120 GLY U CA   1 
ATOM   3962 C  C    . GLY D 4 30  ? 15.118  -7.397  29.658  1.00 76.71  ? 120 GLY U C    1 
ATOM   3963 O  O    . GLY D 4 30  ? 14.129  -8.120  29.610  1.00 74.03  ? 120 GLY U O    1 
ATOM   3964 N  N    . THR D 4 31  ? 15.129  -6.125  29.253  1.00 72.51  ? 121 THR U N    1 
ATOM   3965 C  CA   . THR D 4 31  ? 13.921  -5.428  28.843  1.00 73.45  ? 121 THR U CA   1 
ATOM   3966 C  C    . THR D 4 31  ? 13.717  -5.565  27.328  1.00 73.40  ? 121 THR U C    1 
ATOM   3967 O  O    . THR D 4 31  ? 12.722  -5.063  26.802  1.00 66.96  ? 121 THR U O    1 
ATOM   3968 C  CB   . THR D 4 31  ? 14.005  -3.964  29.303  1.00 70.67  ? 121 THR U CB   1 
ATOM   3969 O  OG1  . THR D 4 31  ? 12.701  -3.381  29.269  1.00 59.68  ? 121 THR U OG1  1 
ATOM   3970 C  CG2  . THR D 4 31  ? 14.977  -3.148  28.471  1.00 70.81  ? 121 THR U CG2  1 
ATOM   3971 N  N    . LYS D 4 32  ? 14.649  -6.246  26.633  1.00 64.12  ? 122 LYS U N    1 
ATOM   3972 C  CA   . LYS D 4 32  ? 14.664  -6.274  25.176  1.00 62.52  ? 122 LYS U CA   1 
ATOM   3973 C  C    . LYS D 4 32  ? 14.420  -7.709  24.698  1.00 52.78  ? 122 LYS U C    1 
ATOM   3974 O  O    . LYS D 4 32  ? 14.925  -8.667  25.285  1.00 48.57  ? 122 LYS U O    1 
ATOM   3975 C  CB   . LYS D 4 32  ? 15.964  -5.637  24.646  1.00 59.54  ? 122 LYS U CB   1 
ATOM   3976 C  CG   . LYS D 4 32  ? 15.769  -4.766  23.408  1.00 67.59  ? 122 LYS U CG   1 
ATOM   3977 C  CD   . LYS D 4 32  ? 16.938  -3.888  22.977  1.00 75.78  ? 122 LYS U CD   1 
ATOM   3978 C  CE   . LYS D 4 32  ? 16.931  -2.479  23.547  1.00 79.26  ? 122 LYS U CE   1 
ATOM   3979 N  NZ   . LYS D 4 32  ? 17.086  -2.477  25.022  1.00 89.10  ? 122 LYS U NZ   1 
ATOM   3980 N  N    . VAL D 4 33  ? 13.604  -7.850  23.642  1.00 45.77  ? 123 VAL U N    1 
ATOM   3981 C  CA   . VAL D 4 33  ? 13.291  -9.159  23.070  1.00 42.31  ? 123 VAL U CA   1 
ATOM   3982 C  C    . VAL D 4 33  ? 13.754  -9.206  21.616  1.00 36.26  ? 123 VAL U C    1 
ATOM   3983 O  O    . VAL D 4 33  ? 13.522  -8.266  20.864  1.00 34.38  ? 123 VAL U O    1 
ATOM   3984 C  CB   . VAL D 4 33  ? 11.788  -9.505  23.159  1.00 39.30  ? 123 VAL U CB   1 
ATOM   3985 C  CG1  . VAL D 4 33  ? 11.446  -10.765 22.387  1.00 41.39  ? 123 VAL U CG1  1 
ATOM   3986 C  CG2  . VAL D 4 33  ? 11.329  -9.670  24.585  1.00 39.74  ? 123 VAL U CG2  1 
ATOM   3987 N  N    . ASN D 4 34  ? 14.369  -10.329 21.240  1.00 35.31  ? 124 ASN U N    1 
ATOM   3988 C  CA   . ASN D 4 34  ? 14.815  -10.585 19.882  1.00 35.53  ? 124 ASN U CA   1 
ATOM   3989 C  C    . ASN D 4 34  ? 13.843  -11.559 19.209  1.00 33.75  ? 124 ASN U C    1 
ATOM   3990 O  O    . ASN D 4 34  ? 13.606  -12.641 19.727  1.00 34.61  ? 124 ASN U O    1 
ATOM   3991 C  CB   . ASN D 4 34  ? 16.219  -11.189 19.863  1.00 39.64  ? 124 ASN U CB   1 
ATOM   3992 C  CG   . ASN D 4 34  ? 16.749  -11.369 18.455  1.00 42.60  ? 124 ASN U CG   1 
ATOM   3993 O  OD1  . ASN D 4 34  ? 17.060  -10.398 17.773  1.00 50.24  ? 124 ASN U OD1  1 
ATOM   3994 N  ND2  . ASN D 4 34  ? 16.838  -12.600 17.998  1.00 43.80  ? 124 ASN U ND2  1 
ATOM   3995 N  N    . VAL D 4 35  ? 13.289  -11.178 18.057  1.00 28.38  ? 125 VAL U N    1 
ATOM   3996 C  CA   . VAL D 4 35  ? 12.376  -12.037 17.326  1.00 27.07  ? 125 VAL U CA   1 
ATOM   3997 C  C    . VAL D 4 35  ? 12.999  -12.418 15.978  1.00 25.51  ? 125 VAL U C    1 
ATOM   3998 O  O    . VAL D 4 35  ? 13.267  -11.548 15.152  1.00 26.74  ? 125 VAL U O    1 
ATOM   3999 C  CB   . VAL D 4 35  ? 11.017  -11.336 17.177  1.00 26.21  ? 125 VAL U CB   1 
ATOM   4000 C  CG1  . VAL D 4 35  ? 10.048  -12.104 16.283  1.00 27.20  ? 125 VAL U CG1  1 
ATOM   4001 C  CG2  . VAL D 4 35  ? 10.411  -11.082 18.546  1.00 26.97  ? 125 VAL U CG2  1 
ATOM   4002 N  N    . THR D 4 36  ? 13.217  -13.718 15.753  1.00 23.77  ? 126 THR U N    1 
ATOM   4003 C  CA   . THR D 4 36  ? 13.878  -14.152 14.533  1.00 28.03  ? 126 THR U CA   1 
ATOM   4004 C  C    . THR D 4 36  ? 12.874  -14.848 13.622  1.00 28.77  ? 126 THR U C    1 
ATOM   4005 O  O    . THR D 4 36  ? 12.191  -15.756 14.067  1.00 27.41  ? 126 THR U O    1 
ATOM   4006 C  CB   . THR D 4 36  ? 15.063  -15.074 14.816  1.00 29.28  ? 126 THR U CB   1 
ATOM   4007 O  OG1  . THR D 4 36  ? 16.107  -14.338 15.472  1.00 30.48  ? 126 THR U OG1  1 
ATOM   4008 C  CG2  . THR D 4 36  ? 15.583  -15.684 13.536  1.00 30.88  ? 126 THR U CG2  1 
ATOM   4009 N  N    . VAL D 4 37  ? 12.788  -14.394 12.362  1.00 31.71  ? 127 VAL U N    1 
ATOM   4010 C  CA   . VAL D 4 37  ? 11.906  -14.971 11.353  1.00 30.30  ? 127 VAL U CA   1 
ATOM   4011 C  C    . VAL D 4 37  ? 12.702  -15.940 10.493  1.00 29.45  ? 127 VAL U C    1 
ATOM   4012 O  O    . VAL D 4 37  ? 13.761  -15.578 9.990   1.00 28.66  ? 127 VAL U O    1 
ATOM   4013 C  CB   . VAL D 4 37  ? 11.308  -13.897 10.430  1.00 31.50  ? 127 VAL U CB   1 
ATOM   4014 C  CG1  . VAL D 4 37  ? 10.432  -14.536 9.349   1.00 32.50  ? 127 VAL U CG1  1 
ATOM   4015 C  CG2  . VAL D 4 37  ? 10.545  -12.833 11.192  1.00 29.38  ? 127 VAL U CG2  1 
ATOM   4016 N  N    . GLU D 4 38  ? 12.137  -17.132 10.277  1.00 32.15  ? 128 GLU U N    1 
ATOM   4017 C  CA   . GLU D 4 38  ? 12.775  -18.213 9.531   1.00 34.81  ? 128 GLU U CA   1 
ATOM   4018 C  C    . GLU D 4 38  ? 12.945  -17.795 8.069   1.00 32.06  ? 128 GLU U C    1 
ATOM   4019 O  O    . GLU D 4 38  ? 12.022  -17.237 7.505   1.00 26.20  ? 128 GLU U O    1 
ATOM   4020 C  CB   . GLU D 4 38  ? 11.891  -19.457 9.662   1.00 39.57  ? 128 GLU U CB   1 
ATOM   4021 C  CG   . GLU D 4 38  ? 12.538  -20.746 9.200   1.00 45.31  ? 128 GLU U CG   1 
ATOM   4022 C  CD   . GLU D 4 38  ? 11.592  -21.935 9.257   1.00 49.17  ? 128 GLU U CD   1 
ATOM   4023 O  OE1  . GLU D 4 38  ? 11.170  -22.321 10.373  1.00 45.92  ? 128 GLU U OE1  1 
ATOM   4024 O  OE2  . GLU D 4 38  ? 11.261  -22.459 8.177   1.00 57.85  ? 128 GLU U OE2  1 
ATOM   4025 N  N    . ASP D 4 39  ? 14.112  -18.026 7.447   1.00 35.64  ? 129 ASP U N    1 
ATOM   4026 C  CA   . ASP D 4 39  ? 14.218  -17.681 6.032   1.00 43.73  ? 129 ASP U CA   1 
ATOM   4027 C  C    . ASP D 4 39  ? 13.493  -18.751 5.222   1.00 40.46  ? 129 ASP U C    1 
ATOM   4028 O  O    . ASP D 4 39  ? 13.909  -19.897 5.237   1.00 40.89  ? 129 ASP U O    1 
ATOM   4029 C  CB   . ASP D 4 39  ? 15.631  -17.395 5.496   1.00 49.69  ? 129 ASP U CB   1 
ATOM   4030 C  CG   . ASP D 4 39  ? 16.792  -18.182 6.076   1.00 52.07  ? 129 ASP U CG   1 
ATOM   4031 O  OD1  . ASP D 4 39  ? 17.500  -17.600 6.917   1.00 49.44  ? 129 ASP U OD1  1 
ATOM   4032 O  OD2  . ASP D 4 39  ? 17.033  -19.324 5.620   1.00 58.18  ? 129 ASP U OD2  1 
ATOM   4033 N  N    . GLU D 4 40  ? 12.397  -18.342 4.558   1.00 36.33  ? 130 GLU U N    1 
ATOM   4034 C  CA   . GLU D 4 40  ? 11.559  -19.245 3.791   1.00 42.14  ? 130 GLU U CA   1 
ATOM   4035 C  C    . GLU D 4 40  ? 12.244  -19.507 2.454   1.00 42.06  ? 130 GLU U C    1 
ATOM   4036 O  O    . GLU D 4 40  ? 12.692  -18.567 1.799   1.00 37.30  ? 130 GLU U O    1 
ATOM   4037 C  CB   . GLU D 4 40  ? 10.110  -18.737 3.666   1.00 46.29  ? 130 GLU U CB   1 
ATOM   4038 C  CG   . GLU D 4 40  ? 9.927   -17.261 3.288   1.00 48.81  ? 130 GLU U CG   1 
ATOM   4039 C  CD   . GLU D 4 40  ? 8.574   -16.639 3.650   1.00 48.20  ? 130 GLU U CD   1 
ATOM   4040 O  OE1  . GLU D 4 40  ? 7.543   -17.009 3.045   1.00 40.66  ? 130 GLU U OE1  1 
ATOM   4041 O  OE2  . GLU D 4 40  ? 8.554   -15.773 4.558   1.00 46.81  ? 130 GLU U OE2  1 
ATOM   4042 N  N    . ARG D 4 41  ? 12.374  -20.800 2.110   1.00 43.14  ? 131 ARG U N    1 
ATOM   4043 C  CA   . ARG D 4 41  ? 13.016  -21.218 0.871   1.00 43.85  ? 131 ARG U CA   1 
ATOM   4044 C  C    . ARG D 4 41  ? 12.046  -20.995 -0.289  1.00 36.87  ? 131 ARG U C    1 
ATOM   4045 O  O    . ARG D 4 41  ? 10.839  -21.038 -0.109  1.00 37.75  ? 131 ARG U O    1 
ATOM   4046 C  CB   . ARG D 4 41  ? 13.558  -22.655 0.930   1.00 51.79  ? 131 ARG U CB   1 
ATOM   4047 C  CG   . ARG D 4 41  ? 13.010  -23.515 2.061   1.00 62.44  ? 131 ARG U CG   1 
ATOM   4048 C  CD   . ARG D 4 41  ? 12.866  -24.996 1.745   1.00 70.55  ? 131 ARG U CD   1 
ATOM   4049 N  NE   . ARG D 4 41  ? 14.099  -25.734 1.490   1.00 71.45  ? 131 ARG U NE   1 
ATOM   4050 C  CZ   . ARG D 4 41  ? 14.157  -27.049 1.255   1.00 72.84  ? 131 ARG U CZ   1 
ATOM   4051 N  NH1  . ARG D 4 41  ? 13.058  -27.789 1.285   1.00 78.94  ? 131 ARG U NH1  1 
ATOM   4052 N  NH2  . ARG D 4 41  ? 15.318  -27.630 0.998   1.00 66.15  ? 131 ARG U NH2  1 
ATOM   4053 N  N    . THR D 4 42  ? 12.611  -20.647 -1.450  1.00 32.85  ? 132 THR U N    1 
ATOM   4054 C  CA   . THR D 4 42  ? 11.908  -20.512 -2.713  1.00 28.31  ? 132 THR U CA   1 
ATOM   4055 C  C    . THR D 4 42  ? 12.278  -21.695 -3.613  1.00 28.87  ? 132 THR U C    1 
ATOM   4056 O  O    . THR D 4 42  ? 13.071  -22.553 -3.229  1.00 29.46  ? 132 THR U O    1 
ATOM   4057 C  CB   . THR D 4 42  ? 12.302  -19.201 -3.405  1.00 27.34  ? 132 THR U CB   1 
ATOM   4058 O  OG1  . THR D 4 42  ? 13.617  -19.376 -3.942  1.00 23.08  ? 132 THR U OG1  1 
ATOM   4059 C  CG2  . THR D 4 42  ? 12.281  -17.996 -2.486  1.00 26.93  ? 132 THR U CG2  1 
ATOM   4060 N  N    . LEU D 4 43  ? 11.734  -21.715 -4.831  1.00 30.30  ? 133 LEU U N    1 
ATOM   4061 C  CA   . LEU D 4 43  ? 12.056  -22.755 -5.787  1.00 31.42  ? 133 LEU U CA   1 
ATOM   4062 C  C    . LEU D 4 43  ? 13.152  -22.298 -6.736  1.00 31.08  ? 133 LEU U C    1 
ATOM   4063 O  O    . LEU D 4 43  ? 13.633  -23.097 -7.529  1.00 32.24  ? 133 LEU U O    1 
ATOM   4064 C  CB   . LEU D 4 43  ? 10.791  -23.224 -6.512  1.00 31.20  ? 133 LEU U CB   1 
ATOM   4065 C  CG   . LEU D 4 43  ? 10.166  -24.429 -5.809  1.00 35.99  ? 133 LEU U CG   1 
ATOM   4066 C  CD1  . LEU D 4 43  ? 9.000   -24.013 -4.933  1.00 36.76  ? 133 LEU U CD1  1 
ATOM   4067 C  CD2  . LEU D 4 43  ? 9.772   -25.517 -6.784  1.00 38.53  ? 133 LEU U CD2  1 
ATOM   4068 N  N    . VAL D 4 44  ? 13.611  -21.057 -6.582  1.00 31.81  ? 134 VAL U N    1 
ATOM   4069 C  CA   . VAL D 4 44  ? 14.818  -20.629 -7.275  1.00 34.52  ? 134 VAL U CA   1 
ATOM   4070 C  C    . VAL D 4 44  ? 16.007  -21.403 -6.701  1.00 34.83  ? 134 VAL U C    1 
ATOM   4071 O  O    . VAL D 4 44  ? 16.231  -21.386 -5.504  1.00 34.85  ? 134 VAL U O    1 
ATOM   4072 C  CB   . VAL D 4 44  ? 15.006  -19.103 -7.168  1.00 32.53  ? 134 VAL U CB   1 
ATOM   4073 C  CG1  . VAL D 4 44  ? 16.214  -18.646 -7.954  1.00 35.27  ? 134 VAL U CG1  1 
ATOM   4074 C  CG2  . VAL D 4 44  ? 13.768  -18.352 -7.631  1.00 31.26  ? 134 VAL U CG2  1 
ATOM   4075 N  N    . ARG D 4 45  ? 16.737  -22.144 -7.538  1.00 42.08  ? 135 ARG U N    1 
ATOM   4076 C  CA   . ARG D 4 45  ? 17.925  -22.848 -7.068  1.00 50.21  ? 135 ARG U CA   1 
ATOM   4077 C  C    . ARG D 4 45  ? 19.155  -22.213 -7.717  1.00 50.50  ? 135 ARG U C    1 
ATOM   4078 O  O    . ARG D 4 45  ? 19.183  -21.974 -8.916  1.00 47.37  ? 135 ARG U O    1 
ATOM   4079 C  CB   . ARG D 4 45  ? 17.848  -24.373 -7.261  1.00 53.45  ? 135 ARG U CB   1 
ATOM   4080 C  CG   . ARG D 4 45  ? 16.880  -24.845 -8.336  1.00 65.27  ? 135 ARG U CG   1 
ATOM   4081 C  CD   . ARG D 4 45  ? 17.144  -26.256 -8.843  1.00 72.78  ? 135 ARG U CD   1 
ATOM   4082 N  NE   . ARG D 4 45  ? 16.065  -27.218 -8.630  1.00 77.54  ? 135 ARG U NE   1 
ATOM   4083 C  CZ   . ARG D 4 45  ? 16.107  -28.231 -7.770  1.00 78.74  ? 135 ARG U CZ   1 
ATOM   4084 N  NH1  . ARG D 4 45  ? 17.044  -28.257 -6.834  1.00 80.23  ? 135 ARG U NH1  1 
ATOM   4085 N  NH2  . ARG D 4 45  ? 15.184  -29.181 -7.820  1.00 68.53  ? 135 ARG U NH2  1 
ATOM   4086 N  N    . ARG D 4 46  ? 20.104  -21.821 -6.861  1.00 55.58  ? 136 ARG U N    1 
ATOM   4087 C  CA   . ARG D 4 46  ? 21.488  -21.567 -7.223  1.00 58.86  ? 136 ARG U CA   1 
ATOM   4088 C  C    . ARG D 4 46  ? 22.240  -22.866 -6.942  1.00 60.18  ? 136 ARG U C    1 
ATOM   4089 O  O    . ARG D 4 46  ? 22.436  -23.213 -5.777  1.00 54.54  ? 136 ARG U O    1 
ATOM   4090 C  CB   . ARG D 4 46  ? 22.027  -20.386 -6.401  1.00 64.52  ? 136 ARG U CB   1 
ATOM   4091 C  CG   . ARG D 4 46  ? 23.346  -19.777 -6.866  1.00 67.52  ? 136 ARG U CG   1 
ATOM   4092 C  CD   . ARG D 4 46  ? 23.204  -18.771 -7.997  1.00 74.07  ? 136 ARG U CD   1 
ATOM   4093 N  NE   . ARG D 4 46  ? 22.561  -17.511 -7.621  1.00 83.15  ? 136 ARG U NE   1 
ATOM   4094 C  CZ   . ARG D 4 46  ? 21.457  -17.000 -8.182  1.00 88.96  ? 136 ARG U CZ   1 
ATOM   4095 N  NH1  . ARG D 4 46  ? 20.741  -17.703 -9.045  1.00 89.86  ? 136 ARG U NH1  1 
ATOM   4096 N  NH2  . ARG D 4 46  ? 21.045  -15.784 -7.853  1.00 83.39  ? 136 ARG U NH2  1 
ATOM   4097 N  N    . ASN D 4 47  ? 22.563  -23.605 -8.017  1.00 70.36  ? 137 ASN U N    1 
ATOM   4098 C  CA   . ASN D 4 47  ? 23.413  -24.795 -7.993  1.00 80.20  ? 137 ASN U CA   1 
ATOM   4099 C  C    . ASN D 4 47  ? 23.009  -25.722 -6.837  1.00 84.86  ? 137 ASN U C    1 
ATOM   4100 O  O    . ASN D 4 47  ? 23.611  -25.729 -5.755  1.00 73.99  ? 137 ASN U O    1 
ATOM   4101 C  CB   . ASN D 4 47  ? 24.912  -24.437 -8.049  1.00 86.44  ? 137 ASN U CB   1 
ATOM   4102 C  CG   . ASN D 4 47  ? 25.435  -23.622 -6.878  1.00 85.71  ? 137 ASN U CG   1 
ATOM   4103 O  OD1  . ASN D 4 47  ? 25.569  -24.140 -5.770  1.00 69.87  ? 137 ASN U OD1  1 
ATOM   4104 N  ND2  . ASN D 4 47  ? 25.777  -22.362 -7.123  1.00 88.14  ? 137 ASN U ND2  1 
ATOM   4105 N  N    . ASN D 4 48  ? 21.964  -26.520 -7.093  1.00 84.19  ? 138 ASN U N    1 
ATOM   4106 C  CA   . ASN D 4 48  ? 21.538  -27.584 -6.194  1.00 83.61  ? 138 ASN U CA   1 
ATOM   4107 C  C    . ASN D 4 48  ? 21.442  -27.062 -4.757  1.00 75.72  ? 138 ASN U C    1 
ATOM   4108 O  O    . ASN D 4 48  ? 21.846  -27.742 -3.821  1.00 74.78  ? 138 ASN U O    1 
ATOM   4109 C  CB   . ASN D 4 48  ? 22.450  -28.809 -6.341  1.00 85.06  ? 138 ASN U CB   1 
ATOM   4110 C  CG   . ASN D 4 48  ? 22.339  -29.466 -7.706  1.00 87.92  ? 138 ASN U CG   1 
ATOM   4111 O  OD1  . ASN D 4 48  ? 21.368  -30.170 -7.985  1.00 82.77  ? 138 ASN U OD1  1 
ATOM   4112 N  ND2  . ASN D 4 48  ? 23.326  -29.253 -8.565  1.00 88.47  ? 138 ASN U ND2  1 
ATOM   4113 N  N    . THR D 4 49  ? 20.883  -25.853 -4.604  1.00 68.73  ? 139 THR U N    1 
ATOM   4114 C  CA   . THR D 4 49  ? 20.588  -25.238 -3.319  1.00 60.34  ? 139 THR U CA   1 
ATOM   4115 C  C    . THR D 4 49  ? 19.440  -24.249 -3.518  1.00 52.47  ? 139 THR U C    1 
ATOM   4116 O  O    . THR D 4 49  ? 19.548  -23.346 -4.340  1.00 51.47  ? 139 THR U O    1 
ATOM   4117 C  CB   . THR D 4 49  ? 21.801  -24.473 -2.772  1.00 63.29  ? 139 THR U CB   1 
ATOM   4118 O  OG1  . THR D 4 49  ? 22.965  -25.285 -2.926  1.00 66.36  ? 139 THR U OG1  1 
ATOM   4119 C  CG2  . THR D 4 49  ? 21.646  -24.068 -1.322  1.00 59.88  ? 139 THR U CG2  1 
ATOM   4120 N  N    . PHE D 4 50  ? 18.329  -24.420 -2.798  1.00 42.36  ? 140 PHE U N    1 
ATOM   4121 C  CA   . PHE D 4 50  ? 17.184  -23.538 -2.974  1.00 35.52  ? 140 PHE U CA   1 
ATOM   4122 C  C    . PHE D 4 50  ? 17.450  -22.206 -2.300  1.00 34.68  ? 140 PHE U C    1 
ATOM   4123 O  O    . PHE D 4 50  ? 17.821  -22.211 -1.142  1.00 41.37  ? 140 PHE U O    1 
ATOM   4124 C  CB   . PHE D 4 50  ? 15.930  -24.152 -2.363  1.00 32.51  ? 140 PHE U CB   1 
ATOM   4125 C  CG   . PHE D 4 50  ? 15.363  -25.314 -3.138  1.00 32.70  ? 140 PHE U CG   1 
ATOM   4126 C  CD1  . PHE D 4 50  ? 14.891  -25.132 -4.429  1.00 32.38  ? 140 PHE U CD1  1 
ATOM   4127 C  CD2  . PHE D 4 50  ? 15.255  -26.574 -2.574  1.00 32.23  ? 140 PHE U CD2  1 
ATOM   4128 C  CE1  . PHE D 4 50  ? 14.345  -26.182 -5.141  1.00 33.29  ? 140 PHE U CE1  1 
ATOM   4129 C  CE2  . PHE D 4 50  ? 14.702  -27.628 -3.288  1.00 33.13  ? 140 PHE U CE2  1 
ATOM   4130 C  CZ   . PHE D 4 50  ? 14.241  -27.428 -4.565  1.00 35.12  ? 140 PHE U CZ   1 
ATOM   4131 N  N    . LEU D 4 51  ? 17.237  -21.083 -2.997  1.00 35.11  ? 141 LEU U N    1 
ATOM   4132 C  CA   . LEU D 4 51  ? 17.481  -19.766 -2.416  1.00 35.57  ? 141 LEU U CA   1 
ATOM   4133 C  C    . LEU D 4 51  ? 16.328  -19.363 -1.501  1.00 34.51  ? 141 LEU U C    1 
ATOM   4134 O  O    . LEU D 4 51  ? 15.173  -19.724 -1.719  1.00 29.20  ? 141 LEU U O    1 
ATOM   4135 C  CB   . LEU D 4 51  ? 17.658  -18.711 -3.520  1.00 36.01  ? 141 LEU U CB   1 
ATOM   4136 C  CG   . LEU D 4 51  ? 18.946  -18.784 -4.350  1.00 35.47  ? 141 LEU U CG   1 
ATOM   4137 C  CD1  . LEU D 4 51  ? 19.002  -17.634 -5.347  1.00 35.64  ? 141 LEU U CD1  1 
ATOM   4138 C  CD2  . LEU D 4 51  ? 20.198  -18.785 -3.480  1.00 31.92  ? 141 LEU U CD2  1 
ATOM   4139 N  N    . SER D 4 52  ? 16.653  -18.543 -0.501  1.00 35.44  ? 142 SER U N    1 
ATOM   4140 C  CA   . SER D 4 52  ? 15.635  -17.952 0.362   1.00 36.49  ? 142 SER U CA   1 
ATOM   4141 C  C    . SER D 4 52  ? 14.985  -16.746 -0.311  1.00 32.59  ? 142 SER U C    1 
ATOM   4142 O  O    . SER D 4 52  ? 15.431  -16.243 -1.334  1.00 34.91  ? 142 SER U O    1 
ATOM   4143 C  CB   . SER D 4 52  ? 16.211  -17.522 1.691   1.00 36.89  ? 142 SER U CB   1 
ATOM   4144 O  OG   . SER D 4 52  ? 16.667  -16.177 1.610   1.00 38.81  ? 142 SER U OG   1 
ATOM   4145 N  N    . LEU D 4 53  ? 13.963  -16.226 0.341   1.00 31.20  ? 143 LEU U N    1 
ATOM   4146 C  CA   . LEU D 4 53  ? 13.223  -15.096 -0.175  1.00 33.02  ? 143 LEU U CA   1 
ATOM   4147 C  C    . LEU D 4 53  ? 14.104  -13.837 -0.085  1.00 33.44  ? 143 LEU U C    1 
ATOM   4148 O  O    . LEU D 4 53  ? 14.051  -12.950 -0.935  1.00 32.19  ? 143 LEU U O    1 
ATOM   4149 C  CB   . LEU D 4 53  ? 11.937  -15.054 0.663   1.00 34.86  ? 143 LEU U CB   1 
ATOM   4150 C  CG   . LEU D 4 53  ? 10.684  -14.492 0.001   1.00 40.20  ? 143 LEU U CG   1 
ATOM   4151 C  CD1  . LEU D 4 53  ? 10.222  -15.330 -1.169  1.00 38.98  ? 143 LEU U CD1  1 
ATOM   4152 C  CD2  . LEU D 4 53  ? 9.569   -14.409 1.025   1.00 46.21  ? 143 LEU U CD2  1 
ATOM   4153 N  N    . ARG D 4 54  ? 14.951  -13.785 0.952   1.00 37.58  ? 144 ARG U N    1 
ATOM   4154 C  CA   . ARG D 4 54  ? 15.917  -12.718 1.187   1.00 36.21  ? 144 ARG U CA   1 
ATOM   4155 C  C    . ARG D 4 54  ? 17.007  -12.772 0.110   1.00 35.24  ? 144 ARG U C    1 
ATOM   4156 O  O    . ARG D 4 54  ? 17.453  -11.726 -0.354  1.00 39.20  ? 144 ARG U O    1 
ATOM   4157 C  CB   . ARG D 4 54  ? 16.426  -12.886 2.627   1.00 36.60  ? 144 ARG U CB   1 
ATOM   4158 C  CG   . ARG D 4 54  ? 17.617  -12.043 3.062   1.00 36.36  ? 144 ARG U CG   1 
ATOM   4159 C  CD   . ARG D 4 54  ? 17.313  -10.579 3.312   1.00 34.13  ? 144 ARG U CD   1 
ATOM   4160 N  NE   . ARG D 4 54  ? 16.238  -10.284 4.250   1.00 29.96  ? 144 ARG U NE   1 
ATOM   4161 C  CZ   . ARG D 4 54  ? 15.434  -9.230  4.115   1.00 29.56  ? 144 ARG U CZ   1 
ATOM   4162 N  NH1  . ARG D 4 54  ? 15.641  -8.373  3.136   1.00 25.82  ? 144 ARG U NH1  1 
ATOM   4163 N  NH2  . ARG D 4 54  ? 14.427  -9.017  4.948   1.00 34.46  ? 144 ARG U NH2  1 
ATOM   4164 N  N    . ASP D 4 55  ? 17.408  -13.979 -0.327  1.00 34.54  ? 145 ASP U N    1 
ATOM   4165 C  CA   . ASP D 4 55  ? 18.459  -14.120 -1.332  1.00 36.72  ? 145 ASP U CA   1 
ATOM   4166 C  C    . ASP D 4 55  ? 18.000  -13.630 -2.697  1.00 35.31  ? 145 ASP U C    1 
ATOM   4167 O  O    . ASP D 4 55  ? 18.818  -13.326 -3.548  1.00 36.85  ? 145 ASP U O    1 
ATOM   4168 C  CB   . ASP D 4 55  ? 18.893  -15.568 -1.542  1.00 38.54  ? 145 ASP U CB   1 
ATOM   4169 C  CG   . ASP D 4 55  ? 19.688  -16.135 -0.387  1.00 39.67  ? 145 ASP U CG   1 
ATOM   4170 O  OD1  . ASP D 4 55  ? 19.968  -15.374 0.548   1.00 43.66  ? 145 ASP U OD1  1 
ATOM   4171 O  OD2  . ASP D 4 55  ? 20.009  -17.332 -0.434  1.00 42.41  ? 145 ASP U OD2  1 
ATOM   4172 N  N    . VAL D 4 56  ? 16.689  -13.599 -2.899  1.00 33.56  ? 146 VAL U N    1 
ATOM   4173 C  CA   . VAL D 4 56  ? 16.105  -13.269 -4.184  1.00 30.57  ? 146 VAL U CA   1 
ATOM   4174 C  C    . VAL D 4 56  ? 15.662  -11.812 -4.198  1.00 25.85  ? 146 VAL U C    1 
ATOM   4175 O  O    . VAL D 4 56  ? 15.871  -11.115 -5.180  1.00 23.37  ? 146 VAL U O    1 
ATOM   4176 C  CB   . VAL D 4 56  ? 14.932  -14.232 -4.455  1.00 30.15  ? 146 VAL U CB   1 
ATOM   4177 C  CG1  . VAL D 4 56  ? 14.052  -13.760 -5.591  1.00 28.74  ? 146 VAL U CG1  1 
ATOM   4178 C  CG2  . VAL D 4 56  ? 15.459  -15.646 -4.698  1.00 29.05  ? 146 VAL U CG2  1 
ATOM   4179 N  N    . PHE D 4 57  ? 15.037  -11.341 -3.118  1.00 25.32  ? 147 PHE U N    1 
ATOM   4180 C  CA   . PHE D 4 57  ? 14.544  -9.973  -3.125  1.00 26.72  ? 147 PHE U CA   1 
ATOM   4181 C  C    . PHE D 4 57  ? 15.572  -9.022  -2.511  1.00 25.05  ? 147 PHE U C    1 
ATOM   4182 O  O    . PHE D 4 57  ? 15.596  -7.840  -2.850  1.00 23.31  ? 147 PHE U O    1 
ATOM   4183 C  CB   . PHE D 4 57  ? 13.181  -9.906  -2.439  1.00 27.02  ? 147 PHE U CB   1 
ATOM   4184 C  CG   . PHE D 4 57  ? 12.058  -10.603 -3.164  1.00 28.43  ? 147 PHE U CG   1 
ATOM   4185 C  CD1  . PHE D 4 57  ? 11.365  -9.970  -4.179  1.00 29.01  ? 147 PHE U CD1  1 
ATOM   4186 C  CD2  . PHE D 4 57  ? 11.689  -11.892 -2.828  1.00 30.37  ? 147 PHE U CD2  1 
ATOM   4187 C  CE1  . PHE D 4 57  ? 10.328  -10.598 -4.839  1.00 28.94  ? 147 PHE U CE1  1 
ATOM   4188 C  CE2  . PHE D 4 57  ? 10.659  -12.524 -3.497  1.00 31.24  ? 147 PHE U CE2  1 
ATOM   4189 C  CZ   . PHE D 4 57  ? 9.969   -11.869 -4.488  1.00 31.05  ? 147 PHE U CZ   1 
ATOM   4190 N  N    . GLY D 4 58  ? 16.418  -9.531  -1.614  1.00 25.84  ? 148 GLY U N    1 
ATOM   4191 C  CA   . GLY D 4 58  ? 17.277  -8.666  -0.818  1.00 28.28  ? 148 GLY U CA   1 
ATOM   4192 C  C    . GLY D 4 58  ? 16.496  -7.508  -0.192  1.00 32.52  ? 148 GLY U C    1 
ATOM   4193 O  O    . GLY D 4 58  ? 15.498  -7.707  0.496   1.00 31.12  ? 148 GLY U O    1 
ATOM   4194 N  N    . LYS D 4 59  ? 16.944  -6.285  -0.486  1.00 38.29  ? 149 LYS U N    1 
ATOM   4195 C  CA   . LYS D 4 59  ? 16.513  -5.080  0.201   1.00 39.71  ? 149 LYS U CA   1 
ATOM   4196 C  C    . LYS D 4 59  ? 15.075  -4.735  -0.179  1.00 37.80  ? 149 LYS U C    1 
ATOM   4197 O  O    . LYS D 4 59  ? 14.479  -3.864  0.465   1.00 38.11  ? 149 LYS U O    1 
ATOM   4198 C  CB   . LYS D 4 59  ? 17.457  -3.919  -0.144  1.00 48.81  ? 149 LYS U CB   1 
ATOM   4199 C  CG   . LYS D 4 59  ? 17.511  -3.563  -1.633  1.00 59.24  ? 149 LYS U CG   1 
ATOM   4200 C  CD   . LYS D 4 59  ? 16.531  -2.474  -2.099  1.00 66.69  ? 149 LYS U CD   1 
ATOM   4201 C  CE   . LYS D 4 59  ? 17.209  -1.217  -2.611  1.00 77.15  ? 149 LYS U CE   1 
ATOM   4202 N  NZ   . LYS D 4 59  ? 18.099  -0.596  -1.596  1.00 82.62  ? 149 LYS U NZ   1 
ATOM   4203 N  N    . ASP D 4 60  ? 14.530  -5.382  -1.223  1.00 33.83  ? 150 ASP U N    1 
ATOM   4204 C  CA   . ASP D 4 60  ? 13.148  -5.135  -1.635  1.00 34.91  ? 150 ASP U CA   1 
ATOM   4205 C  C    . ASP D 4 60  ? 12.147  -5.713  -0.625  1.00 31.79  ? 150 ASP U C    1 
ATOM   4206 O  O    . ASP D 4 60  ? 10.971  -5.334  -0.625  1.00 32.31  ? 150 ASP U O    1 
ATOM   4207 C  CB   . ASP D 4 60  ? 12.855  -5.735  -3.014  1.00 37.30  ? 150 ASP U CB   1 
ATOM   4208 C  CG   . ASP D 4 60  ? 13.330  -4.921  -4.205  1.00 44.33  ? 150 ASP U CG   1 
ATOM   4209 O  OD1  . ASP D 4 60  ? 13.605  -3.706  -4.035  1.00 42.54  ? 150 ASP U OD1  1 
ATOM   4210 O  OD2  . ASP D 4 60  ? 13.394  -5.509  -5.313  1.00 52.24  ? 150 ASP U OD2  1 
ATOM   4211 N  N    . LEU D 4 61  ? 12.614  -6.661  0.201   1.00 28.24  ? 151 LEU U N    1 
ATOM   4212 C  CA   . LEU D 4 61  ? 11.772  -7.401  1.127   1.00 27.50  ? 151 LEU U CA   1 
ATOM   4213 C  C    . LEU D 4 61  ? 11.954  -6.876  2.542   1.00 24.94  ? 151 LEU U C    1 
ATOM   4214 O  O    . LEU D 4 61  ? 13.096  -6.731  2.972   1.00 24.72  ? 151 LEU U O    1 
ATOM   4215 C  CB   . LEU D 4 61  ? 12.203  -8.866  1.091   1.00 27.36  ? 151 LEU U CB   1 
ATOM   4216 C  CG   . LEU D 4 61  ? 11.625  -9.724  2.205   1.00 24.55  ? 151 LEU U CG   1 
ATOM   4217 C  CD1  . LEU D 4 61  ? 10.185  -10.065 1.908   1.00 26.13  ? 151 LEU U CD1  1 
ATOM   4218 C  CD2  . LEU D 4 61  ? 12.457  -10.967 2.384   1.00 24.56  ? 151 LEU U CD2  1 
ATOM   4219 N  N    . ILE D 4 62  ? 10.832  -6.632  3.241   1.00 23.51  ? 152 ILE U N    1 
ATOM   4220 C  CA   . ILE D 4 62  ? 10.848  -6.343  4.672   1.00 24.51  ? 152 ILE U CA   1 
ATOM   4221 C  C    . ILE D 4 62  ? 9.892   -7.274  5.427   1.00 23.94  ? 152 ILE U C    1 
ATOM   4222 O  O    . ILE D 4 62  ? 8.931   -7.788  4.877   1.00 24.02  ? 152 ILE U O    1 
ATOM   4223 C  CB   . ILE D 4 62  ? 10.518  -4.862  4.976   1.00 24.30  ? 152 ILE U CB   1 
ATOM   4224 C  CG1  . ILE D 4 62  ? 9.039   -4.544  4.773   1.00 24.20  ? 152 ILE U CG1  1 
ATOM   4225 C  CG2  . ILE D 4 62  ? 11.413  -3.921  4.176   1.00 24.49  ? 152 ILE U CG2  1 
ATOM   4226 C  CD1  . ILE D 4 62  ? 8.587   -3.297  5.486   1.00 24.43  ? 152 ILE U CD1  1 
ATOM   4227 N  N    . TYR D 4 63  ? 10.156  -7.462  6.719   1.00 23.22  ? 153 TYR U N    1 
ATOM   4228 C  CA   . TYR D 4 63  ? 9.252   -8.198  7.569   1.00 23.85  ? 153 TYR U CA   1 
ATOM   4229 C  C    . TYR D 4 63  ? 8.658   -7.221  8.563   1.00 25.29  ? 153 TYR U C    1 
ATOM   4230 O  O    . TYR D 4 63  ? 9.362   -6.333  9.040   1.00 28.94  ? 153 TYR U O    1 
ATOM   4231 C  CB   . TYR D 4 63  ? 9.943   -9.340  8.298   1.00 23.15  ? 153 TYR U CB   1 
ATOM   4232 C  CG   . TYR D 4 63  ? 10.285  -10.521 7.411   1.00 22.55  ? 153 TYR U CG   1 
ATOM   4233 C  CD1  . TYR D 4 63  ? 9.291   -11.357 6.952   1.00 22.59  ? 153 TYR U CD1  1 
ATOM   4234 C  CD2  . TYR D 4 63  ? 11.593  -10.802 7.037   1.00 23.73  ? 153 TYR U CD2  1 
ATOM   4235 C  CE1  . TYR D 4 63  ? 9.578   -12.461 6.173   1.00 23.95  ? 153 TYR U CE1  1 
ATOM   4236 C  CE2  . TYR D 4 63  ? 11.897  -11.900 6.248   1.00 24.00  ? 153 TYR U CE2  1 
ATOM   4237 C  CZ   . TYR D 4 63  ? 10.883  -12.740 5.823   1.00 25.54  ? 153 TYR U CZ   1 
ATOM   4238 O  OH   . TYR D 4 63  ? 11.113  -13.838 5.046   1.00 29.16  ? 153 TYR U OH   1 
ATOM   4239 N  N    . THR D 4 64  ? 7.354   -7.394  8.799   1.00 25.44  ? 154 THR U N    1 
ATOM   4240 C  CA   . THR D 4 64  ? 6.602   -6.633  9.774   1.00 23.46  ? 154 THR U CA   1 
ATOM   4241 C  C    . THR D 4 64  ? 6.225   -7.560  10.915  1.00 23.63  ? 154 THR U C    1 
ATOM   4242 O  O    . THR D 4 64  ? 5.886   -8.721  10.705  1.00 23.11  ? 154 THR U O    1 
ATOM   4243 C  CB   . THR D 4 64  ? 5.331   -6.038  9.170   1.00 21.89  ? 154 THR U CB   1 
ATOM   4244 O  OG1  . THR D 4 64  ? 5.755   -5.341  8.005   1.00 23.89  ? 154 THR U OG1  1 
ATOM   4245 C  CG2  . THR D 4 64  ? 4.607   -5.097  10.101  1.00 21.50  ? 154 THR U CG2  1 
ATOM   4246 N  N    . LEU D 4 65  ? 6.291   -7.011  12.121  1.00 25.46  ? 155 LEU U N    1 
ATOM   4247 C  CA   . LEU D 4 65  ? 5.893   -7.715  13.317  1.00 25.12  ? 155 LEU U CA   1 
ATOM   4248 C  C    . LEU D 4 65  ? 4.725   -6.990  13.991  1.00 26.83  ? 155 LEU U C    1 
ATOM   4249 O  O    . LEU D 4 65  ? 4.799   -5.796  14.269  1.00 26.68  ? 155 LEU U O    1 
ATOM   4250 C  CB   . LEU D 4 65  ? 7.112   -7.771  14.222  1.00 24.49  ? 155 LEU U CB   1 
ATOM   4251 C  CG   . LEU D 4 65  ? 6.879   -8.406  15.585  1.00 27.01  ? 155 LEU U CG   1 
ATOM   4252 C  CD1  . LEU D 4 65  ? 6.942   -9.926  15.472  1.00 26.59  ? 155 LEU U CD1  1 
ATOM   4253 C  CD2  . LEU D 4 65  ? 7.910   -7.890  16.581  1.00 29.04  ? 155 LEU U CD2  1 
ATOM   4254 N  N    . TYR D 4 66  ? 3.649   -7.742  14.248  1.00 28.44  ? 156 TYR U N    1 
ATOM   4255 C  CA   . TYR D 4 66  ? 2.593   -7.344  15.166  1.00 29.28  ? 156 TYR U CA   1 
ATOM   4256 C  C    . TYR D 4 66  ? 2.859   -8.032  16.494  1.00 29.00  ? 156 TYR U C    1 
ATOM   4257 O  O    . TYR D 4 66  ? 3.096   -9.243  16.506  1.00 29.14  ? 156 TYR U O    1 
ATOM   4258 C  CB   . TYR D 4 66  ? 1.246   -7.760  14.567  1.00 30.39  ? 156 TYR U CB   1 
ATOM   4259 C  CG   . TYR D 4 66  ? 1.019   -7.186  13.174  1.00 35.05  ? 156 TYR U CG   1 
ATOM   4260 C  CD1  . TYR D 4 66  ? 0.569   -5.878  13.006  1.00 39.09  ? 156 TYR U CD1  1 
ATOM   4261 C  CD2  . TYR D 4 66  ? 1.318   -7.917  12.034  1.00 36.86  ? 156 TYR U CD2  1 
ATOM   4262 C  CE1  . TYR D 4 66  ? 0.364   -5.332  11.752  1.00 39.29  ? 156 TYR U CE1  1 
ATOM   4263 C  CE2  . TYR D 4 66  ? 1.137   -7.375  10.771  1.00 41.42  ? 156 TYR U CE2  1 
ATOM   4264 C  CZ   . TYR D 4 66  ? 0.656   -6.082  10.635  1.00 41.80  ? 156 TYR U CZ   1 
ATOM   4265 O  OH   . TYR D 4 66  ? 0.486   -5.503  9.416   1.00 48.30  ? 156 TYR U OH   1 
ATOM   4266 N  N    . TYR D 4 67  ? 2.848   -7.244  17.577  1.00 29.86  ? 157 TYR U N    1 
ATOM   4267 C  CA   . TYR D 4 67  ? 2.934   -7.751  18.941  1.00 30.36  ? 157 TYR U CA   1 
ATOM   4268 C  C    . TYR D 4 67  ? 1.972   -6.987  19.864  1.00 30.15  ? 157 TYR U C    1 
ATOM   4269 O  O    . TYR D 4 67  ? 1.535   -5.871  19.565  1.00 29.04  ? 157 TYR U O    1 
ATOM   4270 C  CB   . TYR D 4 67  ? 4.393   -7.685  19.402  1.00 33.19  ? 157 TYR U CB   1 
ATOM   4271 C  CG   . TYR D 4 67  ? 5.047   -6.308  19.534  1.00 33.73  ? 157 TYR U CG   1 
ATOM   4272 C  CD1  . TYR D 4 67  ? 5.243   -5.696  20.774  1.00 34.70  ? 157 TYR U CD1  1 
ATOM   4273 C  CD2  . TYR D 4 67  ? 5.555   -5.656  18.423  1.00 34.40  ? 157 TYR U CD2  1 
ATOM   4274 C  CE1  . TYR D 4 67  ? 5.876   -4.462  20.883  1.00 36.07  ? 157 TYR U CE1  1 
ATOM   4275 C  CE2  . TYR D 4 67  ? 6.183   -4.421  18.516  1.00 37.00  ? 157 TYR U CE2  1 
ATOM   4276 C  CZ   . TYR D 4 67  ? 6.348   -3.818  19.749  1.00 37.01  ? 157 TYR U CZ   1 
ATOM   4277 O  OH   . TYR D 4 67  ? 6.965   -2.595  19.773  1.00 35.93  ? 157 TYR U OH   1 
ATOM   4278 N  N    . TRP D 4 68  ? 1.618   -7.628  20.983  1.00 31.38  ? 158 TRP U N    1 
ATOM   4279 C  CA   . TRP D 4 68  ? 0.717   -7.063  21.984  1.00 32.76  ? 158 TRP U CA   1 
ATOM   4280 C  C    . TRP D 4 68  ? 0.970   -7.719  23.346  1.00 32.24  ? 158 TRP U C    1 
ATOM   4281 O  O    . TRP D 4 68  ? 1.400   -8.899  23.300  1.00 33.19  ? 158 TRP U O    1 
ATOM   4282 C  CB   . TRP D 4 68  ? -0.751  -7.242  21.577  1.00 31.48  ? 158 TRP U CB   1 
ATOM   4283 C  CG   . TRP D 4 68  ? -1.147  -8.666  21.301  1.00 34.35  ? 158 TRP U CG   1 
ATOM   4284 C  CD1  . TRP D 4 68  ? -1.478  -9.630  22.207  1.00 36.10  ? 158 TRP U CD1  1 
ATOM   4285 C  CD2  . TRP D 4 68  ? -1.218  -9.290  19.998  1.00 41.85  ? 158 TRP U CD2  1 
ATOM   4286 N  NE1  . TRP D 4 68  ? -1.771  -10.805 21.562  1.00 40.48  ? 158 TRP U NE1  1 
ATOM   4287 C  CE2  . TRP D 4 68  ? -1.606  -10.633 20.206  1.00 42.41  ? 158 TRP U CE2  1 
ATOM   4288 C  CE3  . TRP D 4 68  ? -0.984  -8.848  18.684  1.00 48.70  ? 158 TRP U CE3  1 
ATOM   4289 C  CZ2  . TRP D 4 68  ? -1.758  -11.532 19.145  1.00 41.62  ? 158 TRP U CZ2  1 
ATOM   4290 C  CZ3  . TRP D 4 68  ? -1.133  -9.738  17.640  1.00 47.14  ? 158 TRP U CZ3  1 
ATOM   4291 C  CH2  . TRP D 4 68  ? -1.503  -11.064 17.874  1.00 43.90  ? 158 TRP U CH2  1 
ATOM   4292 N  N    . SER D 4 69  ? -6.021  -2.210  25.201  1.00 63.96  ? 163 SER U N    1 
ATOM   4293 C  CA   . SER D 4 69  ? -4.857  -3.027  24.761  1.00 63.95  ? 163 SER U CA   1 
ATOM   4294 C  C    . SER D 4 69  ? -4.914  -3.202  23.243  1.00 67.80  ? 163 SER U C    1 
ATOM   4295 O  O    . SER D 4 69  ? -5.654  -4.047  22.745  1.00 72.88  ? 163 SER U O    1 
ATOM   4296 C  CB   . SER D 4 69  ? -4.787  -4.371  25.491  1.00 57.55  ? 163 SER U CB   1 
ATOM   4297 O  OG   . SER D 4 69  ? -3.910  -4.326  26.620  1.00 50.51  ? 163 SER U OG   1 
ATOM   4298 N  N    . GLY D 4 70  ? -4.135  -2.383  22.519  1.00 66.03  ? 164 GLY U N    1 
ATOM   4299 C  CA   . GLY D 4 70  ? -4.069  -2.443  21.066  1.00 65.74  ? 164 GLY U CA   1 
ATOM   4300 C  C    . GLY D 4 70  ? -2.874  -3.254  20.567  1.00 65.24  ? 164 GLY U C    1 
ATOM   4301 O  O    . GLY D 4 70  ? -2.393  -4.163  21.248  1.00 61.66  ? 164 GLY U O    1 
ATOM   4302 N  N    . LYS D 4 71  ? -2.409  -2.901  19.361  1.00 68.45  ? 165 LYS U N    1 
ATOM   4303 C  CA   . LYS D 4 71  ? -1.343  -3.611  18.671  1.00 65.23  ? 165 LYS U CA   1 
ATOM   4304 C  C    . LYS D 4 71  ? -0.169  -2.659  18.443  1.00 54.87  ? 165 LYS U C    1 
ATOM   4305 O  O    . LYS D 4 71  ? -0.367  -1.477  18.187  1.00 60.47  ? 165 LYS U O    1 
ATOM   4306 C  CB   . LYS D 4 71  ? -1.895  -4.143  17.349  1.00 68.26  ? 165 LYS U CB   1 
ATOM   4307 C  CG   . LYS D 4 71  ? -1.242  -5.421  16.847  1.00 85.12  ? 165 LYS U CG   1 
ATOM   4308 C  CD   . LYS D 4 71  ? -2.013  -6.094  15.723  1.00 92.90  ? 165 LYS U CD   1 
ATOM   4309 C  CE   . LYS D 4 71  ? -3.381  -6.572  16.160  1.00 104.95 ? 165 LYS U CE   1 
ATOM   4310 N  NZ   . LYS D 4 71  ? -4.040  -7.389  15.115  1.00 111.51 ? 165 LYS U NZ   1 
ATOM   4311 N  N    . LYS D 4 72  ? 1.060   -3.167  18.551  1.00 45.60  ? 166 LYS U N    1 
ATOM   4312 C  CA   . LYS D 4 72  ? 2.230   -2.385  18.178  1.00 43.00  ? 166 LYS U CA   1 
ATOM   4313 C  C    . LYS D 4 72  ? 2.879   -3.063  16.972  1.00 36.69  ? 166 LYS U C    1 
ATOM   4314 O  O    . LYS D 4 72  ? 2.693   -4.252  16.746  1.00 35.25  ? 166 LYS U O    1 
ATOM   4315 C  CB   . LYS D 4 72  ? 3.155   -2.249  19.390  1.00 46.70  ? 166 LYS U CB   1 
ATOM   4316 C  CG   . LYS D 4 72  ? 2.426   -2.012  20.713  1.00 54.21  ? 166 LYS U CG   1 
ATOM   4317 C  CD   . LYS D 4 72  ? 3.306   -1.849  21.938  1.00 63.08  ? 166 LYS U CD   1 
ATOM   4318 C  CE   . LYS D 4 72  ? 4.380   -0.783  21.806  1.00 73.57  ? 166 LYS U CE   1 
ATOM   4319 N  NZ   . LYS D 4 72  ? 3.831   0.560   21.486  1.00 76.91  ? 166 LYS U NZ   1 
ATOM   4320 N  N    . THR D 4 73  ? 3.607   -2.306  16.164  1.00 32.40  ? 167 THR U N    1 
ATOM   4321 C  CA   . THR D 4 73  ? 4.234   -2.885  14.994  1.00 31.57  ? 167 THR U CA   1 
ATOM   4322 C  C    . THR D 4 73  ? 5.694   -2.476  14.937  1.00 32.46  ? 167 THR U C    1 
ATOM   4323 O  O    . THR D 4 73  ? 6.041   -1.363  15.337  1.00 33.12  ? 167 THR U O    1 
ATOM   4324 C  CB   . THR D 4 73  ? 3.565   -2.428  13.700  1.00 32.09  ? 167 THR U CB   1 
ATOM   4325 O  OG1  . THR D 4 73  ? 3.857   -1.045  13.558  1.00 35.63  ? 167 THR U OG1  1 
ATOM   4326 C  CG2  . THR D 4 73  ? 2.067   -2.621  13.706  1.00 34.86  ? 167 THR U CG2  1 
ATOM   4327 N  N    . ALA D 4 74  ? 6.516   -3.380  14.387  1.00 31.25  ? 168 ALA U N    1 
ATOM   4328 C  CA   . ALA D 4 74  ? 7.924   -3.127  14.145  1.00 27.77  ? 168 ALA U CA   1 
ATOM   4329 C  C    . ALA D 4 74  ? 8.297   -3.640  12.751  1.00 29.35  ? 168 ALA U C    1 
ATOM   4330 O  O    . ALA D 4 74  ? 7.641   -4.533  12.214  1.00 30.40  ? 168 ALA U O    1 
ATOM   4331 C  CB   . ALA D 4 74  ? 8.742   -3.781  15.226  1.00 24.57  ? 168 ALA U CB   1 
ATOM   4332 N  N    . LYS D 4 75  ? 9.332   -3.028  12.158  1.00 27.04  ? 169 LYS U N    1 
ATOM   4333 C  CA   . LYS D 4 75  ? 9.782   -3.381  10.826  1.00 25.95  ? 169 LYS U CA   1 
ATOM   4334 C  C    . LYS D 4 75  ? 11.266  -3.715  10.880  1.00 23.24  ? 169 LYS U C    1 
ATOM   4335 O  O    . LYS D 4 75  ? 11.980  -3.291  11.772  1.00 22.24  ? 169 LYS U O    1 
ATOM   4336 C  CB   . LYS D 4 75  ? 9.538   -2.227  9.850   1.00 28.10  ? 169 LYS U CB   1 
ATOM   4337 C  CG   . LYS D 4 75  ? 8.203   -2.223  9.113   1.00 29.53  ? 169 LYS U CG   1 
ATOM   4338 C  CD   . LYS D 4 75  ? 7.096   -1.599  9.858   1.00 30.68  ? 169 LYS U CD   1 
ATOM   4339 C  CE   . LYS D 4 75  ? 5.823   -1.446  9.058   1.00 31.82  ? 169 LYS U CE   1 
ATOM   4340 N  NZ   . LYS D 4 75  ? 6.043   -0.710  7.804   1.00 32.60  ? 169 LYS U NZ   1 
ATOM   4341 N  N    . THR D 4 76  ? 11.725  -4.500  9.912   1.00 23.21  ? 170 THR U N    1 
ATOM   4342 C  CA   . THR D 4 76  ? 13.135  -4.874  9.824   1.00 21.62  ? 170 THR U CA   1 
ATOM   4343 C  C    . THR D 4 76  ? 13.466  -5.195  8.377   1.00 25.17  ? 170 THR U C    1 
ATOM   4344 O  O    . THR D 4 76  ? 12.662  -5.849  7.683   1.00 25.26  ? 170 THR U O    1 
ATOM   4345 C  CB   . THR D 4 76  ? 13.474  -6.108  10.672  1.00 19.72  ? 170 THR U CB   1 
ATOM   4346 O  OG1  . THR D 4 76  ? 14.896  -6.182  10.681  1.00 18.49  ? 170 THR U OG1  1 
ATOM   4347 C  CG2  . THR D 4 76  ? 12.839  -7.391  10.162  1.00 17.84  ? 170 THR U CG2  1 
ATOM   4348 N  N    . ASN D 4 77  ? 14.662  -4.774  7.945   1.00 28.87  ? 171 ASN U N    1 
ATOM   4349 C  CA   . ASN D 4 77  ? 15.098  -5.157  6.619   1.00 30.23  ? 171 ASN U CA   1 
ATOM   4350 C  C    . ASN D 4 77  ? 16.062  -6.326  6.748   1.00 27.02  ? 171 ASN U C    1 
ATOM   4351 O  O    . ASN D 4 77  ? 16.705  -6.701  5.765   1.00 30.22  ? 171 ASN U O    1 
ATOM   4352 C  CB   . ASN D 4 77  ? 15.527  -3.975  5.738   1.00 33.51  ? 171 ASN U CB   1 
ATOM   4353 C  CG   . ASN D 4 77  ? 16.550  -3.061  6.352   1.00 36.23  ? 171 ASN U CG   1 
ATOM   4354 O  OD1  . ASN D 4 77  ? 17.505  -3.517  6.978   1.00 42.97  ? 171 ASN U OD1  1 
ATOM   4355 N  ND2  . ASN D 4 77  ? 16.350  -1.769  6.168   1.00 36.87  ? 171 ASN U ND2  1 
ATOM   4356 N  N    . THR D 4 78  ? 16.066  -6.981  7.915   1.00 24.09  ? 172 THR U N    1 
ATOM   4357 C  CA   . THR D 4 78  ? 16.733  -8.271  8.041   1.00 24.26  ? 172 THR U CA   1 
ATOM   4358 C  C    . THR D 4 78  ? 15.703  -9.363  8.344   1.00 23.72  ? 172 THR U C    1 
ATOM   4359 O  O    . THR D 4 78  ? 14.582  -9.303  7.869   1.00 23.33  ? 172 THR U O    1 
ATOM   4360 C  CB   . THR D 4 78  ? 17.865  -8.169  9.065   1.00 25.02  ? 172 THR U CB   1 
ATOM   4361 O  OG1  . THR D 4 78  ? 17.279  -7.968  10.359  1.00 23.91  ? 172 THR U OG1  1 
ATOM   4362 C  CG2  . THR D 4 78  ? 18.835  -7.074  8.676   1.00 25.08  ? 172 THR U CG2  1 
ATOM   4363 N  N    . ASN D 4 79  ? 16.101  -10.395 9.082   1.00 24.35  ? 173 ASN U N    1 
ATOM   4364 C  CA   . ASN D 4 79  ? 15.170  -11.413 9.526   1.00 27.50  ? 173 ASN U CA   1 
ATOM   4365 C  C    . ASN D 4 79  ? 15.018  -11.300 11.037  1.00 28.59  ? 173 ASN U C    1 
ATOM   4366 O  O    . ASN D 4 79  ? 14.587  -12.247 11.678  1.00 29.19  ? 173 ASN U O    1 
ATOM   4367 C  CB   . ASN D 4 79  ? 15.629  -12.822 9.121   1.00 30.11  ? 173 ASN U CB   1 
ATOM   4368 C  CG   . ASN D 4 79  ? 15.239  -13.222 7.708   1.00 36.07  ? 173 ASN U CG   1 
ATOM   4369 O  OD1  . ASN D 4 79  ? 14.572  -14.236 7.502   1.00 39.93  ? 173 ASN U OD1  1 
ATOM   4370 N  ND2  . ASN D 4 79  ? 15.662  -12.453 6.717   1.00 39.22  ? 173 ASN U ND2  1 
ATOM   4371 N  N    . GLU D 4 80  ? 15.388  -10.151 11.613  1.00 30.64  ? 174 GLU U N    1 
ATOM   4372 C  CA   . GLU D 4 80  ? 15.389  -10.027 13.063  1.00 32.14  ? 174 GLU U CA   1 
ATOM   4373 C  C    . GLU D 4 80  ? 14.774  -8.705  13.510  1.00 29.55  ? 174 GLU U C    1 
ATOM   4374 O  O    . GLU D 4 80  ? 15.005  -7.641  12.941  1.00 27.46  ? 174 GLU U O    1 
ATOM   4375 C  CB   . GLU D 4 80  ? 16.801  -10.132 13.632  1.00 35.47  ? 174 GLU U CB   1 
ATOM   4376 C  CG   . GLU D 4 80  ? 17.332  -11.540 13.671  1.00 40.13  ? 174 GLU U CG   1 
ATOM   4377 C  CD   . GLU D 4 80  ? 18.722  -11.626 14.277  1.00 48.32  ? 174 GLU U CD   1 
ATOM   4378 O  OE1  . GLU D 4 80  ? 19.204  -10.592 14.814  1.00 50.05  ? 174 GLU U OE1  1 
ATOM   4379 O  OE2  . GLU D 4 80  ? 19.323  -12.719 14.202  1.00 54.15  ? 174 GLU U OE2  1 
ATOM   4380 N  N    . PHE D 4 81  ? 13.996  -8.803  14.578  1.00 27.43  ? 175 PHE U N    1 
ATOM   4381 C  CA   . PHE D 4 81  ? 13.500  -7.621  15.239  1.00 27.60  ? 175 PHE U CA   1 
ATOM   4382 C  C    . PHE D 4 81  ? 14.097  -7.571  16.643  1.00 27.13  ? 175 PHE U C    1 
ATOM   4383 O  O    . PHE D 4 81  ? 14.218  -8.588  17.329  1.00 22.07  ? 175 PHE U O    1 
ATOM   4384 C  CB   . PHE D 4 81  ? 11.971  -7.625  15.322  1.00 25.45  ? 175 PHE U CB   1 
ATOM   4385 C  CG   . PHE D 4 81  ? 11.218  -7.838  14.041  1.00 23.62  ? 175 PHE U CG   1 
ATOM   4386 C  CD1  . PHE D 4 81  ? 10.606  -6.776  13.400  1.00 25.09  ? 175 PHE U CD1  1 
ATOM   4387 C  CD2  . PHE D 4 81  ? 11.014  -9.113  13.540  1.00 24.13  ? 175 PHE U CD2  1 
ATOM   4388 C  CE1  . PHE D 4 81  ? 9.861   -6.972  12.246  1.00 24.63  ? 175 PHE U CE1  1 
ATOM   4389 C  CE2  . PHE D 4 81  ? 10.272  -9.310  12.386  1.00 22.19  ? 175 PHE U CE2  1 
ATOM   4390 C  CZ   . PHE D 4 81  ? 9.705   -8.241  11.737  1.00 23.45  ? 175 PHE U CZ   1 
ATOM   4391 N  N    . LEU D 4 82  ? 14.420  -6.351  17.064  1.00 28.65  ? 176 LEU U N    1 
ATOM   4392 C  CA   . LEU D 4 82  ? 14.842  -6.117  18.428  1.00 30.55  ? 176 LEU U CA   1 
ATOM   4393 C  C    . LEU D 4 82  ? 13.890  -5.093  19.020  1.00 28.65  ? 176 LEU U C    1 
ATOM   4394 O  O    . LEU D 4 82  ? 13.939  -3.919  18.667  1.00 25.35  ? 176 LEU U O    1 
ATOM   4395 C  CB   . LEU D 4 82  ? 16.299  -5.639  18.447  1.00 33.37  ? 176 LEU U CB   1 
ATOM   4396 C  CG   . LEU D 4 82  ? 17.007  -5.813  19.790  1.00 40.08  ? 176 LEU U CG   1 
ATOM   4397 C  CD1  . LEU D 4 82  ? 17.243  -7.289  20.103  1.00 40.07  ? 176 LEU U CD1  1 
ATOM   4398 C  CD2  . LEU D 4 82  ? 18.332  -5.061  19.807  1.00 43.52  ? 176 LEU U CD2  1 
ATOM   4399 N  N    . ILE D 4 83  ? 13.015  -5.567  19.909  1.00 30.48  ? 177 ILE U N    1 
ATOM   4400 C  CA   . ILE D 4 83  ? 11.979  -4.712  20.457  1.00 35.23  ? 177 ILE U CA   1 
ATOM   4401 C  C    . ILE D 4 83  ? 12.140  -4.550  21.974  1.00 33.76  ? 177 ILE U C    1 
ATOM   4402 O  O    . ILE D 4 83  ? 12.680  -5.428  22.665  1.00 28.25  ? 177 ILE U O    1 
ATOM   4403 C  CB   . ILE D 4 83  ? 10.591  -5.255  20.054  1.00 38.54  ? 177 ILE U CB   1 
ATOM   4404 C  CG1  . ILE D 4 83  ? 10.349  -6.664  20.596  1.00 35.31  ? 177 ILE U CG1  1 
ATOM   4405 C  CG2  . ILE D 4 83  ? 10.419  -5.192  18.542  1.00 39.77  ? 177 ILE U CG2  1 
ATOM   4406 C  CD1  . ILE D 4 83  ? 8.900   -7.012  20.640  1.00 38.51  ? 177 ILE U CD1  1 
ATOM   4407 N  N    . ASP D 4 84  ? 11.666  -3.385  22.446  1.00 35.41  ? 178 ASP U N    1 
ATOM   4408 C  CA   . ASP D 4 84  ? 11.538  -3.066  23.861  1.00 37.91  ? 178 ASP U CA   1 
ATOM   4409 C  C    . ASP D 4 84  ? 10.220  -3.623  24.367  1.00 38.14  ? 178 ASP U C    1 
ATOM   4410 O  O    . ASP D 4 84  ? 9.201   -3.503  23.686  1.00 40.18  ? 178 ASP U O    1 
ATOM   4411 C  CB   . ASP D 4 84  ? 11.552  -1.556  24.111  1.00 38.85  ? 178 ASP U CB   1 
ATOM   4412 C  CG   . ASP D 4 84  ? 12.902  -0.904  23.865  1.00 45.49  ? 178 ASP U CG   1 
ATOM   4413 O  OD1  . ASP D 4 84  ? 13.892  -1.266  24.572  1.00 47.69  ? 178 ASP U OD1  1 
ATOM   4414 O  OD2  . ASP D 4 84  ? 12.956  -0.041  22.971  1.00 45.40  ? 178 ASP U OD2  1 
ATOM   4415 N  N    . VAL D 4 85  ? 10.250  -4.218  25.558  1.00 40.00  ? 179 VAL U N    1 
ATOM   4416 C  CA   . VAL D 4 85  ? 9.033   -4.700  26.190  1.00 47.92  ? 179 VAL U CA   1 
ATOM   4417 C  C    . VAL D 4 85  ? 9.055   -4.388  27.686  1.00 54.50  ? 179 VAL U C    1 
ATOM   4418 O  O    . VAL D 4 85  ? 10.098  -4.089  28.261  1.00 58.82  ? 179 VAL U O    1 
ATOM   4419 C  CB   . VAL D 4 85  ? 8.845   -6.210  25.962  1.00 45.78  ? 179 VAL U CB   1 
ATOM   4420 C  CG1  . VAL D 4 85  ? 8.630   -6.536  24.487  1.00 42.91  ? 179 VAL U CG1  1 
ATOM   4421 C  CG2  . VAL D 4 85  ? 10.001  -7.009  26.564  1.00 43.69  ? 179 VAL U CG2  1 
ATOM   4422 N  N    . ASP D 4 86  ? 7.879   -4.508  28.306  1.00 58.79  ? 180 ASP U N    1 
ATOM   4423 C  CA   . ASP D 4 86  ? 7.717   -4.351  29.737  1.00 56.01  ? 180 ASP U CA   1 
ATOM   4424 C  C    . ASP D 4 86  ? 8.052   -5.666  30.428  1.00 60.60  ? 180 ASP U C    1 
ATOM   4425 O  O    . ASP D 4 86  ? 7.732   -6.726  29.890  1.00 57.18  ? 180 ASP U O    1 
ATOM   4426 C  CB   . ASP D 4 86  ? 6.291   -3.899  30.038  1.00 54.40  ? 180 ASP U CB   1 
ATOM   4427 C  CG   . ASP D 4 86  ? 5.998   -2.539  29.429  1.00 52.69  ? 180 ASP U CG   1 
ATOM   4428 O  OD1  . ASP D 4 86  ? 6.922   -1.706  29.444  1.00 50.18  ? 180 ASP U OD1  1 
ATOM   4429 O  OD2  . ASP D 4 86  ? 4.848   -2.317  28.960  1.00 49.99  ? 180 ASP U OD2  1 
ATOM   4430 N  N    . LYS D 4 87  ? 8.690   -5.560  31.612  1.00 69.65  ? 181 LYS U N    1 
ATOM   4431 C  CA   . LYS D 4 87  ? 9.045   -6.700  32.453  1.00 76.28  ? 181 LYS U CA   1 
ATOM   4432 C  C    . LYS D 4 87  ? 7.773   -7.354  32.992  1.00 69.28  ? 181 LYS U C    1 
ATOM   4433 O  O    . LYS D 4 87  ? 6.799   -6.662  33.308  1.00 63.89  ? 181 LYS U O    1 
ATOM   4434 C  CB   . LYS D 4 87  ? 9.951   -6.261  33.617  1.00 90.28  ? 181 LYS U CB   1 
ATOM   4435 C  CG   . LYS D 4 87  ? 10.490  -7.378  34.516  1.00 100.73 ? 181 LYS U CG   1 
ATOM   4436 C  CD   . LYS D 4 87  ? 9.763   -7.586  35.859  1.00 103.94 ? 181 LYS U CD   1 
ATOM   4437 C  CE   . LYS D 4 87  ? 10.543  -7.143  37.086  1.00 103.52 ? 181 LYS U CE   1 
ATOM   4438 N  NZ   . LYS D 4 87  ? 10.778  -5.679  37.129  1.00 104.17 ? 181 LYS U NZ   1 
ATOM   4439 N  N    . GLY D 4 88  ? 7.783   -8.693  33.057  1.00 63.49  ? 182 GLY U N    1 
ATOM   4440 C  CA   . GLY D 4 88  ? 6.745   -9.434  33.756  1.00 66.75  ? 182 GLY U CA   1 
ATOM   4441 C  C    . GLY D 4 88  ? 5.398   -9.460  33.031  1.00 69.12  ? 182 GLY U C    1 
ATOM   4442 O  O    . GLY D 4 88  ? 4.429   -9.986  33.580  1.00 70.89  ? 182 GLY U O    1 
ATOM   4443 N  N    . GLU D 4 89  ? 5.334   -8.880  31.818  1.00 78.35  ? 183 GLU U N    1 
ATOM   4444 C  CA   . GLU D 4 89  ? 4.185   -9.024  30.929  1.00 77.29  ? 183 GLU U CA   1 
ATOM   4445 C  C    . GLU D 4 89  ? 4.512   -10.047 29.834  1.00 69.90  ? 183 GLU U C    1 
ATOM   4446 O  O    . GLU D 4 89  ? 5.638   -10.103 29.342  1.00 66.42  ? 183 GLU U O    1 
ATOM   4447 C  CB   . GLU D 4 89  ? 3.780   -7.649  30.387  1.00 73.34  ? 183 GLU U CB   1 
ATOM   4448 C  CG   . GLU D 4 89  ? 3.267   -6.721  31.482  1.00 76.38  ? 183 GLU U CG   1 
ATOM   4449 C  CD   . GLU D 4 89  ? 2.555   -5.442  31.060  1.00 83.25  ? 183 GLU U CD   1 
ATOM   4450 O  OE1  . GLU D 4 89  ? 2.448   -5.153  29.842  1.00 91.10  ? 183 GLU U OE1  1 
ATOM   4451 O  OE2  . GLU D 4 89  ? 2.096   -4.732  31.964  1.00 86.35  ? 183 GLU U OE2  1 
ATOM   4452 N  N    . ASN D 4 90  ? 3.533   -10.893 29.483  1.00 64.02  ? 184 ASN U N    1 
ATOM   4453 C  CA   . ASN D 4 90  ? 3.725   -11.873 28.426  1.00 61.96  ? 184 ASN U CA   1 
ATOM   4454 C  C    . ASN D 4 90  ? 3.184   -11.315 27.113  1.00 54.54  ? 184 ASN U C    1 
ATOM   4455 O  O    . ASN D 4 90  ? 2.093   -10.753 27.069  1.00 53.50  ? 184 ASN U O    1 
ATOM   4456 C  CB   . ASN D 4 90  ? 3.101   -13.226 28.773  1.00 68.61  ? 184 ASN U CB   1 
ATOM   4457 C  CG   . ASN D 4 90  ? 3.900   -13.982 29.822  1.00 80.27  ? 184 ASN U CG   1 
ATOM   4458 O  OD1  . ASN D 4 90  ? 3.390   -14.259 30.909  1.00 83.65  ? 184 ASN U OD1  1 
ATOM   4459 N  ND2  . ASN D 4 90  ? 5.150   -14.321 29.522  1.00 72.98  ? 184 ASN U ND2  1 
ATOM   4460 N  N    . TYR D 4 91  ? 3.967   -11.483 26.040  1.00 45.16  ? 185 TYR U N    1 
ATOM   4461 C  CA   . TYR D 4 91  ? 3.658   -10.883 24.748  1.00 36.91  ? 185 TYR U CA   1 
ATOM   4462 C  C    . TYR D 4 91  ? 3.311   -11.985 23.757  1.00 29.78  ? 185 TYR U C    1 
ATOM   4463 O  O    . TYR D 4 91  ? 3.738   -13.127 23.910  1.00 27.29  ? 185 TYR U O    1 
ATOM   4464 C  CB   . TYR D 4 91  ? 4.820   -10.032 24.218  1.00 33.61  ? 185 TYR U CB   1 
ATOM   4465 C  CG   . TYR D 4 91  ? 4.966   -8.650  24.832  1.00 32.89  ? 185 TYR U CG   1 
ATOM   4466 C  CD1  . TYR D 4 91  ? 4.537   -7.531  24.138  1.00 34.44  ? 185 TYR U CD1  1 
ATOM   4467 C  CD2  . TYR D 4 91  ? 5.506   -8.452  26.104  1.00 37.82  ? 185 TYR U CD2  1 
ATOM   4468 C  CE1  . TYR D 4 91  ? 4.664   -6.251  24.658  1.00 33.29  ? 185 TYR U CE1  1 
ATOM   4469 C  CE2  . TYR D 4 91  ? 5.629   -7.178  26.648  1.00 38.41  ? 185 TYR U CE2  1 
ATOM   4470 C  CZ   . TYR D 4 91  ? 5.219   -6.074  25.911  1.00 38.85  ? 185 TYR U CZ   1 
ATOM   4471 O  OH   . TYR D 4 91  ? 5.304   -4.787  26.359  1.00 40.47  ? 185 TYR U OH   1 
ATOM   4472 N  N    . CYS D 4 92  ? 2.507   -11.621 22.760  1.00 32.59  ? 186 CYS U N    1 
ATOM   4473 C  CA   . CYS D 4 92  ? 2.238   -12.487 21.617  1.00 37.24  ? 186 CYS U CA   1 
ATOM   4474 C  C    . CYS D 4 92  ? 2.729   -11.795 20.338  1.00 34.69  ? 186 CYS U C    1 
ATOM   4475 O  O    . CYS D 4 92  ? 2.732   -10.567 20.249  1.00 35.00  ? 186 CYS U O    1 
ATOM   4476 C  CB   . CYS D 4 92  ? 0.751   -12.829 21.522  1.00 39.54  ? 186 CYS U CB   1 
ATOM   4477 S  SG   . CYS D 4 92  ? 0.107   -13.938 22.817  1.00 37.77  ? 186 CYS U SG   1 
ATOM   4478 N  N    . PHE D 4 93  ? 3.141   -12.603 19.358  1.00 33.04  ? 187 PHE U N    1 
ATOM   4479 C  CA   . PHE D 4 93  ? 3.826   -12.139 18.161  1.00 31.50  ? 187 PHE U CA   1 
ATOM   4480 C  C    . PHE D 4 93  ? 3.287   -12.770 16.863  1.00 32.22  ? 187 PHE U C    1 
ATOM   4481 O  O    . PHE D 4 93  ? 2.952   -13.963 16.810  1.00 27.96  ? 187 PHE U O    1 
ATOM   4482 C  CB   . PHE D 4 93  ? 5.296   -12.534 18.266  1.00 32.72  ? 187 PHE U CB   1 
ATOM   4483 C  CG   . PHE D 4 93  ? 6.024   -11.980 19.460  1.00 36.05  ? 187 PHE U CG   1 
ATOM   4484 C  CD1  . PHE D 4 93  ? 6.263   -10.617 19.582  1.00 36.27  ? 187 PHE U CD1  1 
ATOM   4485 C  CD2  . PHE D 4 93  ? 6.528   -12.830 20.432  1.00 36.93  ? 187 PHE U CD2  1 
ATOM   4486 C  CE1  . PHE D 4 93  ? 6.965   -10.114 20.669  1.00 34.35  ? 187 PHE U CE1  1 
ATOM   4487 C  CE2  . PHE D 4 93  ? 7.228   -12.324 21.517  1.00 37.01  ? 187 PHE U CE2  1 
ATOM   4488 C  CZ   . PHE D 4 93  ? 7.434   -10.967 21.639  1.00 34.47  ? 187 PHE U CZ   1 
ATOM   4489 N  N    . SER D 4 94  ? 3.310   -11.987 15.770  1.00 32.40  ? 188 SER U N    1 
ATOM   4490 C  CA   . SER D 4 94  ? 2.980   -12.499 14.448  1.00 33.79  ? 188 SER U CA   1 
ATOM   4491 C  C    . SER D 4 94  ? 3.719   -11.697 13.381  1.00 32.70  ? 188 SER U C    1 
ATOM   4492 O  O    . SER D 4 94  ? 3.831   -10.487 13.540  1.00 35.02  ? 188 SER U O    1 
ATOM   4493 C  CB   . SER D 4 94  ? 1.489   -12.435 14.233  1.00 34.71  ? 188 SER U CB   1 
ATOM   4494 O  OG   . SER D 4 94  ? 1.139   -12.868 12.931  1.00 38.74  ? 188 SER U OG   1 
ATOM   4495 N  N    . VAL D 4 95  ? 4.147   -12.339 12.276  1.00 30.04  ? 189 VAL U N    1 
ATOM   4496 C  CA   . VAL D 4 95  ? 4.908   -11.609 11.275  1.00 31.44  ? 189 VAL U CA   1 
ATOM   4497 C  C    . VAL D 4 95  ? 4.302   -11.757 9.885   1.00 29.03  ? 189 VAL U C    1 
ATOM   4498 O  O    . VAL D 4 95  ? 3.729   -12.777 9.539   1.00 31.61  ? 189 VAL U O    1 
ATOM   4499 C  CB   . VAL D 4 95  ? 6.405   -11.994 11.265  1.00 32.26  ? 189 VAL U CB   1 
ATOM   4500 C  CG1  . VAL D 4 95  ? 7.080   -11.559 12.544  1.00 31.02  ? 189 VAL U CG1  1 
ATOM   4501 C  CG2  . VAL D 4 95  ? 6.647   -13.476 11.031  1.00 32.31  ? 189 VAL U CG2  1 
ATOM   4502 N  N    . GLN D 4 96  ? 4.563   -10.733 9.081   1.00 28.35  ? 190 GLN U N    1 
ATOM   4503 C  CA   . GLN D 4 96  ? 4.103   -10.611 7.711   1.00 31.05  ? 190 GLN U CA   1 
ATOM   4504 C  C    . GLN D 4 96  ? 5.282   -10.143 6.844   1.00 31.64  ? 190 GLN U C    1 
ATOM   4505 O  O    . GLN D 4 96  ? 6.005   -9.194  7.203   1.00 27.49  ? 190 GLN U O    1 
ATOM   4506 C  CB   . GLN D 4 96  ? 2.918   -9.644  7.744   1.00 33.53  ? 190 GLN U CB   1 
ATOM   4507 C  CG   . GLN D 4 96  ? 2.293   -9.318  6.409   1.00 34.49  ? 190 GLN U CG   1 
ATOM   4508 C  CD   . GLN D 4 96  ? 1.085   -8.422  6.584   1.00 36.89  ? 190 GLN U CD   1 
ATOM   4509 O  OE1  . GLN D 4 96  ? 1.144   -7.357  7.189   1.00 39.23  ? 190 GLN U OE1  1 
ATOM   4510 N  NE2  . GLN D 4 96  ? -0.040  -8.837  6.038   1.00 37.82  ? 190 GLN U NE2  1 
ATOM   4511 N  N    . ALA D 4 97  ? 5.507   -10.869 5.732   1.00 29.33  ? 191 ALA U N    1 
ATOM   4512 C  CA   . ALA D 4 97  ? 6.431   -10.465 4.680   1.00 26.23  ? 191 ALA U CA   1 
ATOM   4513 C  C    . ALA D 4 97  ? 5.791   -9.368  3.836   1.00 27.71  ? 191 ALA U C    1 
ATOM   4514 O  O    . ALA D 4 97  ? 4.630   -9.489  3.422   1.00 31.81  ? 191 ALA U O    1 
ATOM   4515 C  CB   . ALA D 4 97  ? 6.802   -11.630 3.801   1.00 24.20  ? 191 ALA U CB   1 
ATOM   4516 N  N    . VAL D 4 98  ? 6.565   -8.307  3.570   1.00 27.44  ? 192 VAL U N    1 
ATOM   4517 C  CA   . VAL D 4 98  ? 6.097   -7.224  2.724   1.00 28.15  ? 192 VAL U CA   1 
ATOM   4518 C  C    . VAL D 4 98  ? 7.187   -6.832  1.740   1.00 27.58  ? 192 VAL U C    1 
ATOM   4519 O  O    . VAL D 4 98  ? 8.361   -6.778  2.103   1.00 28.14  ? 192 VAL U O    1 
ATOM   4520 C  CB   . VAL D 4 98  ? 5.662   -6.002  3.546   1.00 27.16  ? 192 VAL U CB   1 
ATOM   4521 C  CG1  . VAL D 4 98  ? 5.024   -4.952  2.639   1.00 25.41  ? 192 VAL U CG1  1 
ATOM   4522 C  CG2  . VAL D 4 98  ? 4.733   -6.416  4.681   1.00 26.28  ? 192 VAL U CG2  1 
ATOM   4523 N  N    . ILE D 4 99  ? 6.742   -6.526  0.515   1.00 27.88  ? 193 ILE U N    1 
ATOM   4524 C  CA   . ILE D 4 99  ? 7.552   -5.912  -0.527  1.00 28.38  ? 193 ILE U CA   1 
ATOM   4525 C  C    . ILE D 4 99  ? 6.920   -4.566  -0.848  1.00 29.37  ? 193 ILE U C    1 
ATOM   4526 O  O    . ILE D 4 99  ? 5.981   -4.492  -1.640  1.00 29.35  ? 193 ILE U O    1 
ATOM   4527 C  CB   . ILE D 4 99  ? 7.652   -6.817  -1.766  1.00 31.29  ? 193 ILE U CB   1 
ATOM   4528 C  CG1  . ILE D 4 99  ? 8.290   -8.156  -1.397  1.00 35.15  ? 193 ILE U CG1  1 
ATOM   4529 C  CG2  . ILE D 4 99  ? 8.413   -6.116  -2.884  1.00 30.81  ? 193 ILE U CG2  1 
ATOM   4530 C  CD1  . ILE D 4 99  ? 8.286   -9.164  -2.507  1.00 39.95  ? 193 ILE U CD1  1 
ATOM   4531 N  N    . PRO D 4 100 ? 7.360   -3.478  -0.173  1.00 31.58  ? 194 PRO U N    1 
ATOM   4532 C  CA   . PRO D 4 100 ? 6.698   -2.182  -0.294  1.00 31.53  ? 194 PRO U CA   1 
ATOM   4533 C  C    . PRO D 4 100 ? 6.585   -1.665  -1.725  1.00 31.49  ? 194 PRO U C    1 
ATOM   4534 O  O    . PRO D 4 100 ? 5.597   -1.008  -2.035  1.00 28.98  ? 194 PRO U O    1 
ATOM   4535 C  CB   . PRO D 4 100 ? 7.602   -1.245  0.516   1.00 32.04  ? 194 PRO U CB   1 
ATOM   4536 C  CG   . PRO D 4 100 ? 8.279   -2.150  1.510   1.00 31.18  ? 194 PRO U CG   1 
ATOM   4537 C  CD   . PRO D 4 100 ? 8.499   -3.441  0.759   1.00 30.02  ? 194 PRO U CD   1 
ATOM   4538 N  N    . SER D 4 101 ? 7.579   -1.978  -2.581  1.00 32.02  ? 195 SER U N    1 
ATOM   4539 C  CA   . SER D 4 101 ? 7.618   -1.432  -3.935  1.00 33.81  ? 195 SER U CA   1 
ATOM   4540 C  C    . SER D 4 101 ? 6.525   -2.012  -4.842  1.00 37.31  ? 195 SER U C    1 
ATOM   4541 O  O    . SER D 4 101 ? 6.216   -1.408  -5.873  1.00 37.73  ? 195 SER U O    1 
ATOM   4542 C  CB   . SER D 4 101 ? 8.997   -1.546  -4.571  1.00 30.10  ? 195 SER U CB   1 
ATOM   4543 O  OG   . SER D 4 101 ? 9.385   -2.882  -4.801  1.00 27.96  ? 195 SER U OG   1 
ATOM   4544 N  N    . ARG D 4 102 ? 5.904   -3.138  -4.451  1.00 36.92  ? 196 ARG U N    1 
ATOM   4545 C  CA   . ARG D 4 102 ? 4.950   -3.813  -5.317  1.00 36.09  ? 196 ARG U CA   1 
ATOM   4546 C  C    . ARG D 4 102 ? 3.643   -3.036  -5.388  1.00 38.50  ? 196 ARG U C    1 
ATOM   4547 O  O    . ARG D 4 102 ? 3.340   -2.265  -4.495  1.00 38.07  ? 196 ARG U O    1 
ATOM   4548 C  CB   . ARG D 4 102 ? 4.651   -5.224  -4.812  1.00 34.11  ? 196 ARG U CB   1 
ATOM   4549 C  CG   . ARG D 4 102 ? 5.692   -6.269  -5.187  1.00 32.44  ? 196 ARG U CG   1 
ATOM   4550 C  CD   . ARG D 4 102 ? 5.042   -7.621  -4.983  1.00 33.32  ? 196 ARG U CD   1 
ATOM   4551 N  NE   . ARG D 4 102 ? 5.897   -8.752  -5.305  1.00 35.08  ? 196 ARG U NE   1 
ATOM   4552 C  CZ   . ARG D 4 102 ? 5.544   -10.022 -5.148  1.00 34.18  ? 196 ARG U CZ   1 
ATOM   4553 N  NH1  . ARG D 4 102 ? 4.355   -10.321 -4.647  1.00 34.85  ? 196 ARG U NH1  1 
ATOM   4554 N  NH2  . ARG D 4 102 ? 6.382   -10.989 -5.484  1.00 31.91  ? 196 ARG U NH2  1 
ATOM   4555 N  N    . THR D 4 103 ? 2.858   -3.272  -6.449  1.00 48.63  ? 197 THR U N    1 
ATOM   4556 C  CA   . THR D 4 103 ? 1.523   -2.689  -6.578  1.00 53.76  ? 197 THR U CA   1 
ATOM   4557 C  C    . THR D 4 103 ? 0.458   -3.745  -6.268  1.00 52.00  ? 197 THR U C    1 
ATOM   4558 O  O    . THR D 4 103 ? -0.551  -3.464  -5.627  1.00 48.58  ? 197 THR U O    1 
ATOM   4559 C  CB   . THR D 4 103 ? 1.310   -2.058  -7.966  1.00 58.17  ? 197 THR U CB   1 
ATOM   4560 O  OG1  . THR D 4 103 ? 1.301   -3.111  -8.930  1.00 62.63  ? 197 THR U OG1  1 
ATOM   4561 C  CG2  . THR D 4 103 ? 2.359   -1.030  -8.348  1.00 53.76  ? 197 THR U CG2  1 
ATOM   4562 N  N    . VAL D 4 104 ? 0.682   -4.982  -6.716  1.00 52.89  ? 198 VAL U N    1 
ATOM   4563 C  CA   . VAL D 4 104 ? -0.227  -6.069  -6.376  1.00 55.77  ? 198 VAL U CA   1 
ATOM   4564 C  C    . VAL D 4 104 ? 0.531   -7.120  -5.563  1.00 45.88  ? 198 VAL U C    1 
ATOM   4565 O  O    . VAL D 4 104 ? 1.749   -7.229  -5.693  1.00 40.74  ? 198 VAL U O    1 
ATOM   4566 C  CB   . VAL D 4 104 ? -0.912  -6.664  -7.633  1.00 56.50  ? 198 VAL U CB   1 
ATOM   4567 C  CG1  . VAL D 4 104 ? -1.666  -5.589  -8.411  1.00 53.43  ? 198 VAL U CG1  1 
ATOM   4568 C  CG2  . VAL D 4 104 ? 0.038   -7.440  -8.554  1.00 51.40  ? 198 VAL U CG2  1 
ATOM   4569 N  N    . ASN D 4 105 ? -0.214  -7.881  -4.744  1.00 41.28  ? 199 ASN U N    1 
ATOM   4570 C  CA   . ASN D 4 105 ? 0.334   -8.952  -3.920  1.00 46.05  ? 199 ASN U CA   1 
ATOM   4571 C  C    . ASN D 4 105 ? 1.487   -8.415  -3.073  1.00 38.54  ? 199 ASN U C    1 
ATOM   4572 O  O    . ASN D 4 105 ? 2.590   -8.948  -3.108  1.00 31.70  ? 199 ASN U O    1 
ATOM   4573 C  CB   . ASN D 4 105 ? 0.852   -10.152 -4.728  1.00 53.36  ? 199 ASN U CB   1 
ATOM   4574 C  CG   . ASN D 4 105 ? -0.180  -10.779 -5.644  1.00 67.72  ? 199 ASN U CG   1 
ATOM   4575 O  OD1  . ASN D 4 105 ? -1.236  -11.221 -5.195  1.00 71.69  ? 199 ASN U OD1  1 
ATOM   4576 N  ND2  . ASN D 4 105 ? 0.120   -10.834 -6.934  1.00 76.18  ? 199 ASN U ND2  1 
ATOM   4577 N  N    . ARG D 4 106 ? 1.229   -7.356  -2.315  1.00 35.32  ? 200 ARG U N    1 
ATOM   4578 C  CA   . ARG D 4 106 ? 2.312   -6.704  -1.614  1.00 39.74  ? 200 ARG U CA   1 
ATOM   4579 C  C    . ARG D 4 106 ? 2.630   -7.462  -0.331  1.00 33.41  ? 200 ARG U C    1 
ATOM   4580 O  O    . ARG D 4 106 ? 3.760   -7.416  0.118   1.00 30.33  ? 200 ARG U O    1 
ATOM   4581 C  CB   . ARG D 4 106 ? 1.971   -5.250  -1.288  1.00 46.49  ? 200 ARG U CB   1 
ATOM   4582 C  CG   . ARG D 4 106 ? 1.536   -4.419  -2.487  1.00 53.10  ? 200 ARG U CG   1 
ATOM   4583 C  CD   . ARG D 4 106 ? 1.270   -2.972  -2.077  1.00 54.71  ? 200 ARG U CD   1 
ATOM   4584 N  NE   . ARG D 4 106 ? 2.456   -2.301  -1.536  1.00 50.45  ? 200 ARG U NE   1 
ATOM   4585 C  CZ   . ARG D 4 106 ? 2.636   -1.940  -0.264  1.00 48.22  ? 200 ARG U CZ   1 
ATOM   4586 N  NH1  . ARG D 4 106 ? 1.829   -2.386  0.680   1.00 49.17  ? 200 ARG U NH1  1 
ATOM   4587 N  NH2  . ARG D 4 106 ? 3.653   -1.161  0.075   1.00 45.21  ? 200 ARG U NH2  1 
ATOM   4588 N  N    . LYS D 4 107 ? 1.640   -8.128  0.267   1.00 34.01  ? 201 LYS U N    1 
ATOM   4589 C  CA   . LYS D 4 107 ? 1.810   -8.682  1.606   1.00 37.36  ? 201 LYS U CA   1 
ATOM   4590 C  C    . LYS D 4 107 ? 1.645   -10.198 1.582   1.00 29.11  ? 201 LYS U C    1 
ATOM   4591 O  O    . LYS D 4 107 ? 0.742   -10.729 0.952   1.00 25.68  ? 201 LYS U O    1 
ATOM   4592 C  CB   . LYS D 4 107 ? 0.806   -8.096  2.606   1.00 41.19  ? 201 LYS U CB   1 
ATOM   4593 C  CG   . LYS D 4 107 ? 1.210   -6.791  3.277   1.00 51.31  ? 201 LYS U CG   1 
ATOM   4594 C  CD   . LYS D 4 107 ? 0.434   -5.587  2.768   1.00 65.31  ? 201 LYS U CD   1 
ATOM   4595 C  CE   . LYS D 4 107 ? 0.882   -4.262  3.357   1.00 70.35  ? 201 LYS U CE   1 
ATOM   4596 N  NZ   . LYS D 4 107 ? 0.619   -4.178  4.814   1.00 71.21  ? 201 LYS U NZ   1 
ATOM   4597 N  N    . SER D 4 108 ? 2.512   -10.899 2.305   1.00 27.66  ? 202 SER U N    1 
ATOM   4598 C  CA   . SER D 4 108 ? 2.220   -12.286 2.624   1.00 27.62  ? 202 SER U CA   1 
ATOM   4599 C  C    . SER D 4 108 ? 1.020   -12.332 3.548   1.00 29.46  ? 202 SER U C    1 
ATOM   4600 O  O    . SER D 4 108 ? 0.518   -11.302 3.993   1.00 31.25  ? 202 SER U O    1 
ATOM   4601 C  CB   . SER D 4 108 ? 3.346   -12.973 3.311   1.00 25.77  ? 202 SER U CB   1 
ATOM   4602 O  OG   . SER D 4 108 ? 3.306   -12.655 4.687   1.00 26.07  ? 202 SER U OG   1 
ATOM   4603 N  N    . THR D 4 109 ? 0.611   -13.559 3.854   1.00 31.08  ? 203 THR U N    1 
ATOM   4604 C  CA   . THR D 4 109 ? -0.362  -13.803 4.903   1.00 34.39  ? 203 THR U CA   1 
ATOM   4605 C  C    . THR D 4 109 ? 0.389   -13.777 6.227   1.00 32.85  ? 203 THR U C    1 
ATOM   4606 O  O    . THR D 4 109 ? 1.611   -13.922 6.225   1.00 34.06  ? 203 THR U O    1 
ATOM   4607 C  CB   . THR D 4 109 ? -1.097  -15.123 4.636   1.00 36.29  ? 203 THR U CB   1 
ATOM   4608 O  OG1  . THR D 4 109 ? -2.141  -15.159 5.614   1.00 40.77  ? 203 THR U OG1  1 
ATOM   4609 C  CG2  . THR D 4 109 ? -0.187  -16.338 4.711   1.00 34.95  ? 203 THR U CG2  1 
ATOM   4610 N  N    . ASP D 4 110 ? -0.334  -13.585 7.336   1.00 30.83  ? 204 ASP U N    1 
ATOM   4611 C  CA   . ASP D 4 110 ? 0.294   -13.500 8.647   1.00 29.50  ? 204 ASP U CA   1 
ATOM   4612 C  C    . ASP D 4 110 ? 0.788   -14.881 9.085   1.00 26.11  ? 204 ASP U C    1 
ATOM   4613 O  O    . ASP D 4 110 ? 0.117   -15.873 8.806   1.00 24.66  ? 204 ASP U O    1 
ATOM   4614 C  CB   . ASP D 4 110 ? -0.673  -12.890 9.665   1.00 30.79  ? 204 ASP U CB   1 
ATOM   4615 C  CG   . ASP D 4 110 ? -0.976  -11.431 9.380   1.00 33.74  ? 204 ASP U CG   1 
ATOM   4616 O  OD1  . ASP D 4 110 ? -0.057  -10.598 9.457   1.00 38.13  ? 204 ASP U OD1  1 
ATOM   4617 O  OD2  . ASP D 4 110 ? -2.119  -11.138 9.071   1.00 38.25  ? 204 ASP U OD2  1 
ATOM   4618 N  N    . SER D 4 111 ? 1.922   -14.927 9.814   1.00 23.23  ? 205 SER U N    1 
ATOM   4619 C  CA   . SER D 4 111 ? 2.408   -16.159 10.431  1.00 24.02  ? 205 SER U CA   1 
ATOM   4620 C  C    . SER D 4 111 ? 1.462   -16.660 11.516  1.00 25.92  ? 205 SER U C    1 
ATOM   4621 O  O    . SER D 4 111 ? 0.647   -15.921 12.061  1.00 33.12  ? 205 SER U O    1 
ATOM   4622 C  CB   . SER D 4 111 ? 3.776   -16.020 11.053  1.00 22.00  ? 205 SER U CB   1 
ATOM   4623 O  OG   . SER D 4 111 ? 3.712   -15.317 12.287  1.00 22.39  ? 205 SER U OG   1 
ATOM   4624 N  N    . PRO D 4 112 ? 1.583   -17.936 11.922  1.00 25.34  ? 206 PRO U N    1 
ATOM   4625 C  CA   . PRO D 4 112 ? 1.072   -18.359 13.220  1.00 26.08  ? 206 PRO U CA   1 
ATOM   4626 C  C    . PRO D 4 112 ? 1.534   -17.401 14.304  1.00 28.85  ? 206 PRO U C    1 
ATOM   4627 O  O    . PRO D 4 112 ? 2.646   -16.875 14.248  1.00 33.69  ? 206 PRO U O    1 
ATOM   4628 C  CB   . PRO D 4 112 ? 1.682   -19.755 13.436  1.00 26.55  ? 206 PRO U CB   1 
ATOM   4629 C  CG   . PRO D 4 112 ? 1.972   -20.273 12.038  1.00 26.12  ? 206 PRO U CG   1 
ATOM   4630 C  CD   . PRO D 4 112 ? 2.166   -19.046 11.156  1.00 26.15  ? 206 PRO U CD   1 
ATOM   4631 N  N    . VAL D 4 113 ? 0.653   -17.199 15.283  1.00 32.57  ? 207 VAL U N    1 
ATOM   4632 C  CA   . VAL D 4 113 ? 0.890   -16.355 16.435  1.00 31.13  ? 207 VAL U CA   1 
ATOM   4633 C  C    . VAL D 4 113 ? 1.608   -17.198 17.469  1.00 33.61  ? 207 VAL U C    1 
ATOM   4634 O  O    . VAL D 4 113 ? 1.175   -18.315 17.712  1.00 30.79  ? 207 VAL U O    1 
ATOM   4635 C  CB   . VAL D 4 113 ? -0.435  -15.815 16.998  1.00 32.94  ? 207 VAL U CB   1 
ATOM   4636 C  CG1  . VAL D 4 113 ? -0.227  -14.990 18.265  1.00 36.93  ? 207 VAL U CG1  1 
ATOM   4637 C  CG2  . VAL D 4 113 ? -1.199  -15.022 15.951  1.00 32.65  ? 207 VAL U CG2  1 
ATOM   4638 N  N    . GLU D 4 114 ? 2.701   -16.651 18.039  1.00 39.15  ? 208 GLU U N    1 
ATOM   4639 C  CA   . GLU D 4 114 ? 3.471   -17.298 19.091  1.00 36.58  ? 208 GLU U CA   1 
ATOM   4640 C  C    . GLU D 4 114 ? 3.403   -16.405 20.323  1.00 40.30  ? 208 GLU U C    1 
ATOM   4641 O  O    . GLU D 4 114 ? 3.336   -15.182 20.175  1.00 44.11  ? 208 GLU U O    1 
ATOM   4642 C  CB   . GLU D 4 114 ? 4.923   -17.478 18.660  1.00 39.11  ? 208 GLU U CB   1 
ATOM   4643 C  CG   . GLU D 4 114 ? 5.116   -18.410 17.477  1.00 44.29  ? 208 GLU U CG   1 
ATOM   4644 C  CD   . GLU D 4 114 ? 4.791   -19.868 17.746  1.00 50.60  ? 208 GLU U CD   1 
ATOM   4645 O  OE1  . GLU D 4 114 ? 4.959   -20.301 18.900  1.00 50.67  ? 208 GLU U OE1  1 
ATOM   4646 O  OE2  . GLU D 4 114 ? 4.401   -20.573 16.792  1.00 59.30  ? 208 GLU U OE2  1 
ATOM   4647 N  N    . CYS D 4 115 ? 3.386   -17.011 21.522  1.00 39.01  ? 209 CYS U N    1 
ATOM   4648 C  CA   . CYS D 4 115 ? 3.349   -16.241 22.757  1.00 40.38  ? 209 CYS U CA   1 
ATOM   4649 C  C    . CYS D 4 115 ? 4.374   -16.759 23.759  1.00 39.91  ? 209 CYS U C    1 
ATOM   4650 O  O    . CYS D 4 115 ? 4.778   -17.919 23.720  1.00 34.88  ? 209 CYS U O    1 
ATOM   4651 C  CB   . CYS D 4 115 ? 1.976   -16.268 23.420  1.00 38.89  ? 209 CYS U CB   1 
ATOM   4652 S  SG   . CYS D 4 115 ? 0.610   -15.823 22.322  1.00 35.06  ? 209 CYS U SG   1 
ATOM   4653 N  N    . MET D 4 116 ? 4.754   -15.870 24.682  1.00 46.79  ? 210 MET U N    1 
ATOM   4654 C  CA   . MET D 4 116 ? 5.712   -16.179 25.741  1.00 51.47  ? 210 MET U CA   1 
ATOM   4655 C  C    . MET D 4 116 ? 5.004   -16.987 26.850  1.00 54.51  ? 210 MET U C    1 
ATOM   4656 O  O    . MET D 4 116 ? 5.421   -18.168 27.088  1.00 44.53  ? 210 MET U O    1 
ATOM   4657 C  CB   . MET D 4 116 ? 6.294   -14.878 26.316  1.00 50.16  ? 210 MET U CB   1 
ATOM   4658 C  CG   . MET D 4 116 ? 6.787   -13.951 25.224  1.00 51.56  ? 210 MET U CG   1 
ATOM   4659 S  SD   . MET D 4 116 ? 8.083   -12.775 25.648  1.00 51.01  ? 210 MET U SD   1 
ATOM   4660 C  CE   . MET D 4 116 ? 7.275   -11.703 26.832  1.00 51.34  ? 210 MET U CE   1 
ATOM   4661 O  OXT  . MET D 4 116 ? 4.036   -16.423 27.428  1.00 51.07  ? 210 MET U OXT  1 
HETATM 4662 C  C2   . BGC E 5 .   ? -3.338  -35.379 -1.029  1.00 62.88  ? 201 BGC L C2   1 
HETATM 4663 C  C3   . BGC E 5 .   ? -3.679  -34.221 -1.933  1.00 63.14  ? 201 BGC L C3   1 
HETATM 4664 C  C4   . BGC E 5 .   ? -4.429  -33.142 -1.174  1.00 63.08  ? 201 BGC L C4   1 
HETATM 4665 C  C5   . BGC E 5 .   ? -3.614  -32.745 0.035   1.00 59.73  ? 201 BGC L C5   1 
HETATM 4666 C  C6   . BGC E 5 .   ? -4.255  -31.669 0.879   1.00 71.10  ? 201 BGC L C6   1 
HETATM 4667 C  C1   . BGC E 5 .   ? -2.684  -34.907 0.259   1.00 59.45  ? 201 BGC L C1   1 
HETATM 4668 O  O2   . BGC E 5 .   ? -2.490  -36.301 -1.714  1.00 70.17  ? 201 BGC L O2   1 
HETATM 4669 O  O3   . BGC E 5 .   ? -4.458  -34.743 -3.006  1.00 65.71  ? 201 BGC L O3   1 
HETATM 4670 O  O4   . BGC E 5 .   ? -4.673  -31.997 -1.991  1.00 65.97  ? 201 BGC L O4   1 
HETATM 4671 O  O5   . BGC E 5 .   ? -3.488  -33.901 0.863   1.00 54.94  ? 201 BGC L O5   1 
HETATM 4672 O  O6   . BGC E 5 .   ? -3.835  -31.763 2.253   1.00 77.45  ? 201 BGC L O6   1 
HETATM 4673 C  C1   . FUC F 6 .   ? 13.256  -31.716 1.261   1.00 41.77  ? 202 FUC L C1   1 
HETATM 4674 C  C2   . FUC F 6 .   ? 14.232  -32.812 1.689   1.00 43.00  ? 202 FUC L C2   1 
HETATM 4675 C  C3   . FUC F 6 .   ? 14.299  -33.894 0.642   1.00 45.92  ? 202 FUC L C3   1 
HETATM 4676 C  C4   . FUC F 6 .   ? 14.772  -33.249 -0.650  1.00 45.81  ? 202 FUC L C4   1 
HETATM 4677 C  C5   . FUC F 6 .   ? 13.765  -32.164 -1.058  1.00 45.25  ? 202 FUC L C5   1 
HETATM 4678 C  C6   . FUC F 6 .   ? 14.149  -31.411 -2.315  1.00 44.23  ? 202 FUC L C6   1 
HETATM 4679 O  O2   . FUC F 6 .   ? 13.864  -33.361 2.947   1.00 40.87  ? 202 FUC L O2   1 
HETATM 4680 O  O3   . FUC F 6 .   ? 15.153  -34.960 1.072   1.00 45.22  ? 202 FUC L O3   1 
HETATM 4681 O  O4   . FUC F 6 .   ? 16.073  -32.709 -0.416  1.00 45.27  ? 202 FUC L O4   1 
HETATM 4682 O  O5   . FUC F 6 .   ? 13.619  -31.172 -0.008  1.00 41.13  ? 202 FUC L O5   1 
HETATM 4683 CA CA   . CA  G 7 .   ? -1.714  -25.244 6.322   1.00 58.30  2 203 CA  L CA   1 
HETATM 4684 CA CA   . CA  H 7 .   ? -13.405 -23.863 28.981  1.00 123.10 2 204 CA  L CA   1 
HETATM 4685 CA CA   . CA  I 7 .   ? -10.223 -23.661 28.943  1.00 103.04 2 205 CA  L CA   1 
HETATM 4686 CA CA   . CA  J 7 .   ? -9.478  -27.227 28.287  1.00 105.89 2 206 CA  L CA   1 
HETATM 4687 CA CA   . CA  K 7 .   ? -6.526  -29.429 29.109  1.00 127.72 2 207 CA  L CA   1 
HETATM 4688 CA CA   . CA  L 7 .   ? 3.325   -26.788 26.261  1.00 87.24  2 208 CA  L CA   1 
HETATM 4689 CA CA   . CA  M 7 .   ? -3.140  -32.419 28.425  1.00 107.46 2 209 CA  L CA   1 
HETATM 4690 CA CA   . CA  N 7 .   ? -15.609 -20.165 26.819  1.00 91.85  2 210 CA  L CA   1 
HETATM 4691 CA CA   . CA  O 7 .   ? 27.647  -7.149  -58.525 1.00 43.97  2 301 CA  H CA   1 
HETATM 4692 C  C1   . XGX P 8 .   ? 4.452   -6.754  -51.053 1.00 21.18  ? 302 XGX H C1   1 
HETATM 4693 C  C2   . XGX P 8 .   ? 4.632   -6.419  -49.732 1.00 20.99  ? 302 XGX H C2   1 
HETATM 4694 C  C3   . XGX P 8 .   ? 5.483   -7.173  -48.922 1.00 25.01  ? 302 XGX H C3   1 
HETATM 4695 C  C4   . XGX P 8 .   ? 6.120   -8.292  -49.484 1.00 25.50  ? 302 XGX H C4   1 
HETATM 4696 C  C5   . XGX P 8 .   ? 5.946   -8.618  -50.813 1.00 24.90  ? 302 XGX H C5   1 
HETATM 4697 C  C6   . XGX P 8 .   ? 5.113   -7.845  -51.619 1.00 21.94  ? 302 XGX H C6   1 
HETATM 4698 C  C7   . XGX P 8 .   ? 4.393   -7.496  -53.965 1.00 19.59  ? 302 XGX H C7   1 
HETATM 4699 N  N1   . XGX P 8 .   ? 4.879   -8.255  -52.961 1.00 20.95  ? 302 XGX H N1   1 
HETATM 4700 C  C8   . XGX P 8 .   ? 4.808   -6.618  -56.892 1.00 27.97  ? 302 XGX H C8   1 
HETATM 4701 C  C9   . XGX P 8 .   ? 4.204   -5.518  -57.499 1.00 31.06  ? 302 XGX H C9   1 
HETATM 4702 C  C10  . XGX P 8 .   ? 4.939   -4.446  -57.948 1.00 31.65  ? 302 XGX H C10  1 
HETATM 4703 C  C11  . XGX P 8 .   ? 6.326   -4.467  -57.848 1.00 37.58  ? 302 XGX H C11  1 
HETATM 4704 C  C12  . XGX P 8 .   ? 6.958   -5.582  -57.256 1.00 33.10  ? 302 XGX H C12  1 
HETATM 4705 C  C13  . XGX P 8 .   ? 6.212   -6.647  -56.782 1.00 28.46  ? 302 XGX H C13  1 
HETATM 4706 C  C14  . XGX P 8 .   ? 6.924   -7.819  -56.159 1.00 28.20  ? 302 XGX H C14  1 
HETATM 4707 O  O1   . XGX P 8 .   ? 7.484   -7.706  -55.023 1.00 25.56  ? 302 XGX H O1   1 
HETATM 4708 O  O2   . XGX P 8 .   ? 6.879   -8.896  -56.794 1.00 26.97  ? 302 XGX H O2   1 
HETATM 4709 C  C15  . XGX P 8 .   ? 7.085   -3.269  -58.311 1.00 44.64  ? 302 XGX H C15  1 
HETATM 4710 N  N2   . XGX P 8 .   ? 8.235   -3.456  -59.172 1.00 47.34  ? 302 XGX H N2   1 
HETATM 4711 O  O3   . XGX P 8 .   ? 6.687   -2.161  -57.961 1.00 41.02  ? 302 XGX H O3   1 
HETATM 4712 C  C16  . XGX P 8 .   ? 9.585   -3.693  -58.591 1.00 53.95  ? 302 XGX H C16  1 
HETATM 4713 C  C17  . XGX P 8 .   ? 10.148  -5.112  -58.856 1.00 66.28  ? 302 XGX H C17  1 
HETATM 4714 C  C18  . XGX P 8 .   ? 9.421   -5.935  -59.930 1.00 67.76  ? 302 XGX H C18  1 
HETATM 4715 C  C19  . XGX P 8 .   ? 11.646  -5.065  -59.185 1.00 65.52  ? 302 XGX H C19  1 
HETATM 4716 C  C20  . XGX P 8 .   ? 2.430   -9.478  -57.199 1.00 19.79  ? 302 XGX H C20  1 
HETATM 4717 C  C21  . XGX P 8 .   ? 2.255   -9.927  -55.891 1.00 19.14  ? 302 XGX H C21  1 
HETATM 4718 C  C22  . XGX P 8 .   ? 2.948   -9.273  -54.868 1.00 19.97  ? 302 XGX H C22  1 
HETATM 4719 C  C23  . XGX P 8 .   ? 3.810   -8.212  -55.142 1.00 19.23  ? 302 XGX H C23  1 
HETATM 4720 C  C24  . XGX P 8 .   ? 3.926   -7.738  -56.458 1.00 21.55  ? 302 XGX H C24  1 
HETATM 4721 C  C25  . XGX P 8 .   ? 3.249   -8.404  -57.472 1.00 19.78  ? 302 XGX H C25  1 
HETATM 4722 C  C26  . XGX P 8 .   ? 1.442   -11.991 -54.771 1.00 21.45  ? 302 XGX H C26  1 
HETATM 4723 C  C27  . XGX P 8 .   ? 1.359   -11.046 -55.670 1.00 19.12  ? 302 XGX H C27  1 
HETATM 4724 O  O4   . XGX P 8 .   ? 4.282   -6.281  -53.871 1.00 21.17  ? 302 XGX H O4   1 
HETATM 4725 C  C28  . XGX P 8 .   ? 5.633   -6.882  -47.477 1.00 23.14  ? 302 XGX H C28  1 
HETATM 4726 N  N3   . XGX P 8 .   ? 6.172   -7.785  -46.699 1.00 23.93  ? 302 XGX H N3   1 
HETATM 4727 N  N4   . XGX P 8 .   ? 5.132   -5.795  -46.936 1.00 26.87  ? 302 XGX H N4   1 
HETATM 4728 O  O    . HOH Q 9 .   ? 11.797  -32.808 -34.642 1.00 36.61  ? 301 HOH L O    1 
HETATM 4729 O  O    . HOH Q 9 .   ? 7.495   -33.335 2.754   1.00 42.23  ? 302 HOH L O    1 
HETATM 4730 O  O    . HOH Q 9 .   ? 16.423  -33.215 -45.688 1.00 23.64  ? 303 HOH L O    1 
HETATM 4731 O  O    . HOH Q 9 .   ? -2.084  -18.851 15.131  1.00 23.29  ? 304 HOH L O    1 
HETATM 4732 O  O    . HOH Q 9 .   ? -14.431 -33.665 30.975  1.00 65.40  ? 305 HOH L O    1 
HETATM 4733 O  O    . HOH Q 9 .   ? 16.479  -32.139 -49.644 1.00 34.13  ? 306 HOH L O    1 
HETATM 4734 O  O    . HOH Q 9 .   ? -0.905  -30.982 20.371  1.00 57.94  ? 307 HOH L O    1 
HETATM 4735 O  O    . HOH Q 9 .   ? 4.942   -31.698 -15.170 1.00 37.01  ? 308 HOH L O    1 
HETATM 4736 O  O    . HOH Q 9 .   ? 4.690   -35.192 0.788   1.00 32.11  ? 309 HOH L O    1 
HETATM 4737 O  O    . HOH Q 9 .   ? -11.885 -24.880 24.147  1.00 30.21  ? 310 HOH L O    1 
HETATM 4738 O  O    . HOH Q 9 .   ? 24.665  -30.209 -47.403 1.00 24.89  ? 311 HOH L O    1 
HETATM 4739 O  O    . HOH Q 9 .   ? -6.660  -28.551 16.230  1.00 41.94  ? 312 HOH L O    1 
HETATM 4740 O  O    . HOH Q 9 .   ? 28.920  -24.384 -46.222 1.00 23.25  ? 313 HOH L O    1 
HETATM 4741 O  O    . HOH Q 9 .   ? 11.567  -28.382 -7.530  1.00 24.89  ? 314 HOH L O    1 
HETATM 4742 O  O    . HOH Q 9 .   ? 5.654   -27.600 6.142   1.00 38.38  ? 315 HOH L O    1 
HETATM 4743 O  O    . HOH Q 9 .   ? 11.064  -42.532 -6.514  1.00 37.41  ? 316 HOH L O    1 
HETATM 4744 O  O    . HOH Q 9 .   ? -19.262 -21.662 27.140  1.00 37.44  ? 317 HOH L O    1 
HETATM 4745 O  O    . HOH Q 9 .   ? 9.965   -44.963 -37.013 1.00 39.85  ? 318 HOH L O    1 
HETATM 4746 O  O    . HOH Q 9 .   ? 25.483  -42.812 -28.062 1.00 42.18  ? 319 HOH L O    1 
HETATM 4747 O  O    . HOH Q 9 .   ? 23.640  -40.933 -26.691 1.00 34.68  ? 320 HOH L O    1 
HETATM 4748 O  O    . HOH Q 9 .   ? -15.473 -32.231 36.009  1.00 36.55  ? 321 HOH L O    1 
HETATM 4749 O  O    . HOH Q 9 .   ? -6.025  -36.555 24.759  1.00 31.68  ? 322 HOH L O    1 
HETATM 4750 O  O    . HOH Q 9 .   ? 36.684  -15.217 -44.063 1.00 48.54  ? 323 HOH L O    1 
HETATM 4751 O  O    . HOH Q 9 .   ? 5.107   -34.464 3.276   1.00 37.88  ? 324 HOH L O    1 
HETATM 4752 O  O    . HOH Q 9 .   ? -2.947  -33.315 21.629  1.00 57.44  ? 325 HOH L O    1 
HETATM 4753 O  O    . HOH Q 9 .   ? -2.813  -26.512 -2.760  1.00 35.69  ? 326 HOH L O    1 
HETATM 4754 O  O    . HOH Q 9 .   ? 3.610   -34.550 25.197  1.00 33.87  ? 327 HOH L O    1 
HETATM 4755 O  O    . HOH Q 9 .   ? 3.383   -41.123 -4.875  1.00 48.27  ? 328 HOH L O    1 
HETATM 4756 O  O    . HOH Q 9 .   ? 2.479   -34.057 27.579  1.00 43.75  ? 329 HOH L O    1 
HETATM 4757 O  O    . HOH Q 9 .   ? -1.310  -36.607 23.946  1.00 36.98  ? 330 HOH L O    1 
HETATM 4758 O  O    . HOH Q 9 .   ? 9.927   -47.540 -37.512 1.00 35.27  ? 331 HOH L O    1 
HETATM 4759 O  O    . HOH Q 9 .   ? -15.179 -6.464  17.418  1.00 37.79  ? 332 HOH L O    1 
HETATM 4760 O  O    . HOH R 9 .   ? 28.080  -11.366 -39.043 1.00 47.47  ? 401 HOH H O    1 
HETATM 4761 O  O    . HOH R 9 .   ? 31.911  -9.813  -45.704 1.00 43.23  ? 402 HOH H O    1 
HETATM 4762 O  O    . HOH R 9 .   ? 4.067   -15.966 -67.447 1.00 58.78  ? 403 HOH H O    1 
HETATM 4763 O  O    . HOH R 9 .   ? 14.577  -26.860 -29.741 1.00 23.38  ? 404 HOH H O    1 
HETATM 4764 O  O    . HOH R 9 .   ? 1.875   -16.355 -32.256 1.00 12.80  ? 405 HOH H O    1 
HETATM 4765 O  O    . HOH R 9 .   ? 12.195  -37.189 -50.527 1.00 48.22  ? 406 HOH H O    1 
HETATM 4766 O  O    . HOH R 9 .   ? 19.814  -15.561 -45.390 1.00 25.67  ? 407 HOH H O    1 
HETATM 4767 O  O    . HOH R 9 .   ? 24.412  -15.947 -53.249 1.00 17.96  ? 408 HOH H O    1 
HETATM 4768 O  O    . HOH R 9 .   ? 16.660  -17.662 -37.094 1.00 17.03  ? 409 HOH H O    1 
HETATM 4769 O  O    . HOH R 9 .   ? -4.699  -27.702 -45.658 1.00 35.57  ? 410 HOH H O    1 
HETATM 4770 O  O    . HOH R 9 .   ? 20.174  -27.783 -37.049 1.00 24.73  ? 411 HOH H O    1 
HETATM 4771 O  O    . HOH R 9 .   ? 0.890   -16.749 -39.287 1.00 22.28  ? 412 HOH H O    1 
HETATM 4772 O  O    . HOH R 9 .   ? 11.080  1.934   -56.677 1.00 37.59  ? 413 HOH H O    1 
HETATM 4773 O  O    . HOH R 9 .   ? 28.368  -28.493 -65.519 1.00 27.80  ? 414 HOH H O    1 
HETATM 4774 O  O    . HOH R 9 .   ? 16.143  -3.720  -63.063 1.00 36.09  ? 415 HOH H O    1 
HETATM 4775 O  O    . HOH R 9 .   ? 17.437  -13.891 -45.550 1.00 31.83  ? 416 HOH H O    1 
HETATM 4776 O  O    . HOH R 9 .   ? 31.102  -17.676 -56.256 1.00 18.63  ? 417 HOH H O    1 
HETATM 4777 O  O    . HOH R 9 .   ? 13.632  -27.227 -68.798 1.00 60.97  ? 418 HOH H O    1 
HETATM 4778 O  O    . HOH R 9 .   ? 2.665   -30.852 -65.673 1.00 55.37  ? 419 HOH H O    1 
HETATM 4779 O  O    . HOH R 9 .   ? 36.038  -12.356 -52.896 1.00 37.27  ? 420 HOH H O    1 
HETATM 4780 O  O    . HOH R 9 .   ? 6.611   -11.476 -64.373 1.00 28.84  ? 421 HOH H O    1 
HETATM 4781 O  O    . HOH R 9 .   ? 14.965  -36.143 -44.750 1.00 32.07  ? 422 HOH H O    1 
HETATM 4782 O  O    . HOH R 9 .   ? 31.187  -20.885 -62.162 1.00 34.55  ? 423 HOH H O    1 
HETATM 4783 O  O    . HOH R 9 .   ? 26.209  -4.544  -42.666 1.00 23.70  ? 424 HOH H O    1 
HETATM 4784 O  O    . HOH R 9 .   ? 24.072  -1.854  -42.643 1.00 30.29  ? 425 HOH H O    1 
HETATM 4785 O  O    . HOH R 9 .   ? 16.328  -6.844  -37.626 1.00 24.68  ? 426 HOH H O    1 
HETATM 4786 O  O    . HOH R 9 .   ? 19.008  -28.407 -48.887 1.00 21.23  ? 427 HOH H O    1 
HETATM 4787 O  O    . HOH R 9 .   ? -7.692  -8.489  -38.849 1.00 32.98  ? 428 HOH H O    1 
HETATM 4788 O  O    . HOH R 9 .   ? 6.544   -6.394  -40.804 1.00 20.00  ? 429 HOH H O    1 
HETATM 4789 O  O    . HOH R 9 .   ? -6.471  -22.469 -53.240 1.00 42.99  ? 430 HOH H O    1 
HETATM 4790 O  O    . HOH R 9 .   ? 3.380   -28.502 -34.916 1.00 38.33  ? 431 HOH H O    1 
HETATM 4791 O  O    . HOH R 9 .   ? 5.810   -12.819 -32.194 1.00 31.28  ? 432 HOH H O    1 
HETATM 4792 O  O    . HOH R 9 .   ? -1.434  -0.817  -47.248 1.00 44.36  ? 433 HOH H O    1 
HETATM 4793 O  O    . HOH R 9 .   ? -8.869  -18.663 -47.957 1.00 39.36  ? 434 HOH H O    1 
HETATM 4794 O  O    . HOH R 9 .   ? 5.984   -2.566  -61.182 1.00 33.71  ? 435 HOH H O    1 
HETATM 4795 O  O    . HOH R 9 .   ? -1.012  -23.809 -41.485 1.00 34.70  ? 436 HOH H O    1 
HETATM 4796 O  O    . HOH R 9 .   ? 2.904   -27.469 -68.085 1.00 38.49  ? 437 HOH H O    1 
HETATM 4797 O  O    . HOH R 9 .   ? 24.762  -29.483 -71.832 1.00 44.72  ? 438 HOH H O    1 
HETATM 4798 O  O    . HOH R 9 .   ? -8.625  -19.134 -45.132 1.00 37.54  ? 439 HOH H O    1 
HETATM 4799 O  O    . HOH R 9 .   ? 17.245  -2.543  -35.370 1.00 38.71  ? 440 HOH H O    1 
HETATM 4800 O  O    . HOH R 9 .   ? 12.455  -16.008 -80.195 1.00 44.73  ? 441 HOH H O    1 
HETATM 4801 O  O    . HOH R 9 .   ? -8.157  -17.683 -50.185 1.00 39.92  ? 442 HOH H O    1 
HETATM 4802 O  O    . HOH R 9 .   ? 12.285  -13.382 -78.825 1.00 50.52  ? 443 HOH H O    1 
HETATM 4803 O  O    . HOH R 9 .   ? -9.005  -21.056 -47.594 1.00 40.75  ? 444 HOH H O    1 
HETATM 4804 O  O    . HOH R 9 .   ? -10.277 -18.971 -43.074 1.00 41.88  ? 445 HOH H O    1 
HETATM 4805 O  O    . HOH R 9 .   ? 6.171   -10.436 -76.856 1.00 43.12  ? 446 HOH H O    1 
HETATM 4806 O  O    . HOH R 9 .   ? 7.215   -8.052  -75.985 1.00 46.07  ? 447 HOH H O    1 
HETATM 4807 O  O    . HOH R 9 .   ? 1.495   -3.081  -58.422 1.00 51.46  ? 448 HOH H O    1 
HETATM 4808 O  O    . HOH R 9 .   ? -3.197  1.079   -46.651 1.00 28.52  ? 449 HOH H O    1 
HETATM 4809 O  O    . HOH R 9 .   ? 16.156  -20.910 -80.864 1.00 39.96  ? 450 HOH H O    1 
HETATM 4810 O  O    . HOH R 9 .   ? -0.937  -4.543  -57.173 1.00 39.37  ? 451 HOH H O    1 
HETATM 4811 O  O    . HOH S 9 .   ? -12.633 -23.099 -28.274 1.00 47.16  ? 101 HOH T O    1 
HETATM 4812 O  O    . HOH S 9 .   ? -13.791 -22.696 -12.316 1.00 33.30  ? 102 HOH T O    1 
HETATM 4813 O  O    . HOH S 9 .   ? -11.436 -34.534 -30.508 1.00 54.23  ? 103 HOH T O    1 
HETATM 4814 O  O    . HOH S 9 .   ? -1.202  -37.994 -21.532 1.00 25.84  ? 104 HOH T O    1 
HETATM 4815 O  O    . HOH S 9 .   ? -11.259 -17.303 -20.044 1.00 44.30  ? 105 HOH T O    1 
HETATM 4816 O  O    . HOH S 9 .   ? -13.442 -40.171 -24.934 1.00 49.41  ? 106 HOH T O    1 
HETATM 4817 O  O    . HOH S 9 .   ? 11.804  -17.998 -24.539 1.00 26.70  ? 107 HOH T O    1 
HETATM 4818 O  O    . HOH S 9 .   ? 6.514   -30.802 -18.714 1.00 31.30  ? 108 HOH T O    1 
HETATM 4819 O  O    . HOH S 9 .   ? 2.790   -35.341 -20.260 1.00 34.83  ? 109 HOH T O    1 
HETATM 4820 O  O    . HOH S 9 .   ? -14.258 -18.779 -19.375 1.00 57.90  ? 110 HOH T O    1 
HETATM 4821 O  O    . HOH S 9 .   ? 13.928  -17.317 -19.131 1.00 35.87  ? 111 HOH T O    1 
HETATM 4822 O  O    . HOH S 9 .   ? -0.031  -21.454 -5.366  1.00 31.77  ? 112 HOH T O    1 
HETATM 4823 O  O    . HOH S 9 .   ? -3.408  -15.263 -13.867 1.00 29.15  ? 113 HOH T O    1 
HETATM 4824 O  O    . HOH S 9 .   ? 2.354   -30.629 -14.759 1.00 16.36  ? 114 HOH T O    1 
HETATM 4825 O  O    . HOH S 9 .   ? 1.515   -23.101 -6.781  1.00 29.38  ? 115 HOH T O    1 
HETATM 4826 O  O    . HOH S 9 .   ? -10.424 -27.615 -14.551 1.00 33.85  ? 116 HOH T O    1 
HETATM 4827 O  O    . HOH S 9 .   ? 1.495   -37.964 -20.260 1.00 34.50  ? 117 HOH T O    1 
HETATM 4828 O  O    . HOH T 9 .   ? 1.247   -15.689 2.049   1.00 40.51  ? 301 HOH U O    1 
HETATM 4829 O  O    . HOH T 9 .   ? 18.901  -7.560  4.941   1.00 32.68  ? 302 HOH U O    1 
HETATM 4830 O  O    . HOH T 9 .   ? 2.121   -12.181 -1.819  1.00 35.68  ? 303 HOH U O    1 
HETATM 4831 O  O    . HOH T 9 .   ? 19.260  -19.439 -10.559 1.00 40.58  ? 304 HOH U O    1 
HETATM 4832 O  O    . HOH T 9 .   ? 13.223  -25.689 -8.432  1.00 35.08  ? 305 HOH U O    1 
HETATM 4833 O  O    . HOH T 9 .   ? 18.825  -14.980 15.907  1.00 27.87  ? 306 HOH U O    1 
HETATM 4834 O  O    . HOH T 9 .   ? 16.128  -3.616  -5.318  1.00 48.80  ? 307 HOH U O    1 
HETATM 4835 O  O    . HOH T 9 .   ? 2.982   -19.586 -38.149 1.00 18.08  ? 308 HOH U O    1 
HETATM 4836 O  O    . HOH T 9 .   ? -2.816  -15.127 8.399   1.00 33.71  ? 309 HOH U O    1 
HETATM 4837 O  O    . HOH T 9 .   ? 5.580   -1.690  4.979   1.00 43.68  ? 310 HOH U O    1 
HETATM 4838 O  O    . HOH T 9 .   ? 3.351   -5.835  -8.039  1.00 39.01  ? 311 HOH U O    1 
HETATM 4839 O  O    . HOH T 9 .   ? 7.458   -23.167 8.460   1.00 63.11  ? 312 HOH U O    1 
HETATM 4840 O  O    . HOH T 9 .   ? 18.409  -12.236 10.142  1.00 32.84  ? 313 HOH U O    1 
HETATM 4841 O  O    . HOH T 9 .   ? 3.089   0.783   16.381  1.00 42.87  ? 314 HOH U O    1 
HETATM 4842 O  O    . HOH T 9 .   ? 0.301   -15.664 -8.141  1.00 41.36  ? 315 HOH U O    1 
HETATM 4843 O  O    . HOH T 9 .   ? -0.453  -2.600  8.261   1.00 39.07  ? 316 HOH U O    1 
HETATM 4844 O  O    . HOH T 9 .   ? 23.057  -15.193 -0.673  1.00 40.83  ? 317 HOH U O    1 
HETATM 4845 O  O    . HOH T 9 .   ? 22.572  -13.473 -2.827  1.00 34.92  ? 318 HOH U O    1 
HETATM 4846 O  O    . HOH T 9 .   ? 8.976   -21.551 18.816  1.00 45.48  ? 319 HOH U O    1 
HETATM 4847 O  O    . HOH T 9 .   ? 6.859   -25.169 10.645  1.00 40.76  ? 320 HOH U O    1 
HETATM 4848 O  O    . HOH T 9 .   ? -3.931  -12.802 0.699   1.00 39.26  ? 321 HOH U O    1 
# 
