data_9URH
# 
_entry.id   9URH 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9URH         pdb_00009urh 10.2210/pdb9urh/pdb 
WWPDB D_1300059033 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-28 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9URH 
_pdbx_database_status.recvd_initial_deposition_date   2025-04-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              neelsb@icgeb.res.in 
_pdbx_contact_author.name_first         Neel 
_pdbx_contact_author.name_last          Bhavesh 
_pdbx_contact_author.name_mi            Sarovar 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7248-4978 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Patra, A.'     1 0000-0003-1527-2204 
'Bhavesh, N.S.' 2 0000-0002-7248-4978 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structural insight into DNA recognition by RRM1+2 domain of human ETR-3 protein' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Patra, A.'     1 0000-0003-1527-2204 
primary 'Bhavesh, N.S.' 2 0000-0002-7248-4978 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'CUGBP Elav-like family member 2' 20213.293 1   ? ? ? ?             
2 polymer     syn 
;DNA (5'-D(P*TP*GP*GP*TP*C)-3')
;
1800.203  1   ? ? ? 'CGT repeats' 
3 non-polymer syn 'MAGNESIUM ION'                   24.305    1   ? ? ? ?             
4 water       nat water                             18.015    107 ? ? ? ?             
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;CELF-2,Bruno-like protein 3,CUG triplet repeat RNA-binding protein 2,CUG-BP2,CUG-BP- and ETR-3-like factor 2,ELAV-type RNA-binding protein 3,ETR-3,Neuroblastoma apoptosis-related RNA-binding protein,hNAPOR,RNA-binding protein BRUNOL-3
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no 
;GSHMDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPG
MHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKA
MHQSQTMEGCSSPIVVKFAD
;
;GSHMDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPG
MHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKA
MHQSQTMEGCSSPIVVKFAD
;
A ? 
2 polydeoxyribonucleotide no no '(DC)(DT)(DG)(DG)(DT)(DC)' CTGGTC B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'MAGNESIUM ION' MG  
4 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   MET n 
1 5   ASP n 
1 6   PRO n 
1 7   ASP n 
1 8   ALA n 
1 9   ILE n 
1 10  LYS n 
1 11  MET n 
1 12  PHE n 
1 13  VAL n 
1 14  GLY n 
1 15  GLN n 
1 16  ILE n 
1 17  PRO n 
1 18  ARG n 
1 19  SER n 
1 20  TRP n 
1 21  SER n 
1 22  GLU n 
1 23  LYS n 
1 24  GLU n 
1 25  LEU n 
1 26  LYS n 
1 27  GLU n 
1 28  LEU n 
1 29  PHE n 
1 30  GLU n 
1 31  PRO n 
1 32  TYR n 
1 33  GLY n 
1 34  ALA n 
1 35  VAL n 
1 36  TYR n 
1 37  GLN n 
1 38  ILE n 
1 39  ASN n 
1 40  VAL n 
1 41  LEU n 
1 42  ARG n 
1 43  ASP n 
1 44  ARG n 
1 45  SER n 
1 46  GLN n 
1 47  ASN n 
1 48  PRO n 
1 49  PRO n 
1 50  GLN n 
1 51  SER n 
1 52  LYS n 
1 53  GLY n 
1 54  CYS n 
1 55  CYS n 
1 56  PHE n 
1 57  VAL n 
1 58  THR n 
1 59  PHE n 
1 60  TYR n 
1 61  THR n 
1 62  ARG n 
1 63  LYS n 
1 64  ALA n 
1 65  ALA n 
1 66  LEU n 
1 67  GLU n 
1 68  ALA n 
1 69  GLN n 
1 70  ASN n 
1 71  ALA n 
1 72  LEU n 
1 73  HIS n 
1 74  ASN n 
1 75  ILE n 
1 76  LYS n 
1 77  THR n 
1 78  LEU n 
1 79  PRO n 
1 80  GLY n 
1 81  MET n 
1 82  HIS n 
1 83  HIS n 
1 84  PRO n 
1 85  ILE n 
1 86  GLN n 
1 87  MET n 
1 88  LYS n 
1 89  PRO n 
1 90  ALA n 
1 91  ASP n 
1 92  SER n 
1 93  GLU n 
1 94  LYS n 
1 95  SER n 
1 96  ASN n 
1 97  ALA n 
1 98  VAL n 
1 99  GLU n 
1 100 ASP n 
1 101 ARG n 
1 102 LYS n 
1 103 LEU n 
1 104 PHE n 
1 105 ILE n 
1 106 GLY n 
1 107 MET n 
1 108 VAL n 
1 109 SER n 
1 110 LYS n 
1 111 LYS n 
1 112 CYS n 
1 113 ASN n 
1 114 GLU n 
1 115 ASN n 
1 116 ASP n 
1 117 ILE n 
1 118 ARG n 
1 119 VAL n 
1 120 MET n 
1 121 PHE n 
1 122 SER n 
1 123 PRO n 
1 124 PHE n 
1 125 GLY n 
1 126 GLN n 
1 127 ILE n 
1 128 GLU n 
1 129 GLU n 
1 130 CYS n 
1 131 ARG n 
1 132 ILE n 
1 133 LEU n 
1 134 ARG n 
1 135 GLY n 
1 136 PRO n 
1 137 ASP n 
1 138 GLY n 
1 139 LEU n 
1 140 SER n 
1 141 ARG n 
1 142 GLY n 
1 143 CYS n 
1 144 ALA n 
1 145 PHE n 
1 146 VAL n 
1 147 THR n 
1 148 PHE n 
1 149 SER n 
1 150 THR n 
1 151 ARG n 
1 152 ALA n 
1 153 MET n 
1 154 ALA n 
1 155 GLN n 
1 156 ASN n 
1 157 ALA n 
1 158 ILE n 
1 159 LYS n 
1 160 ALA n 
1 161 MET n 
1 162 HIS n 
1 163 GLN n 
1 164 SER n 
1 165 GLN n 
1 166 THR n 
1 167 MET n 
1 168 GLU n 
1 169 GLY n 
1 170 CYS n 
1 171 SER n 
1 172 SER n 
1 173 PRO n 
1 174 ILE n 
1 175 VAL n 
1 176 VAL n 
1 177 LYS n 
1 178 PHE n 
1 179 ALA n 
1 180 ASP n 
2 1   DC  n 
2 2   DT  n 
2 3   DG  n 
2 4   DG  n 
2 5   DT  n 
2 6   DC  n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   180 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'CELF2, BRUNOL3, CUGBP2, ETR3, NAPOR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       6 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                              ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                             ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                           ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                      ? 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE                             ? 'C3 H7 N O2 S'    121.158 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"         ? 'C10 H15 N2 O8 P' 322.208 
GLN 'L-peptide linking' y GLUTAMINE                            ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                      ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                              ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                            ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                           ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                              ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                               ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                           ? 'C5 H11 N O2 S'   149.211 
MG  non-polymer         . 'MAGNESIUM ION'                      ? 'Mg 2'            24.305  
PHE 'L-peptide linking' y PHENYLALANINE                        ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                              ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                               ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                            ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                           ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                             ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                               ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -3  ?   ?   ?   A . n 
A 1 2   SER 2   -2  ?   ?   ?   A . n 
A 1 3   HIS 3   -1  ?   ?   ?   A . n 
A 1 4   MET 4   0   0   MET MET A . n 
A 1 5   ASP 5   1   1   ASP ASP A . n 
A 1 6   PRO 6   2   2   PRO PRO A . n 
A 1 7   ASP 7   3   3   ASP ASP A . n 
A 1 8   ALA 8   4   4   ALA ALA A . n 
A 1 9   ILE 9   5   5   ILE ILE A . n 
A 1 10  LYS 10  6   6   LYS LYS A . n 
A 1 11  MET 11  7   7   MET MET A . n 
A 1 12  PHE 12  8   8   PHE PHE A . n 
A 1 13  VAL 13  9   9   VAL VAL A . n 
A 1 14  GLY 14  10  10  GLY GLY A . n 
A 1 15  GLN 15  11  11  GLN GLN A . n 
A 1 16  ILE 16  12  12  ILE ILE A . n 
A 1 17  PRO 17  13  13  PRO PRO A . n 
A 1 18  ARG 18  14  14  ARG ARG A . n 
A 1 19  SER 19  15  15  SER SER A . n 
A 1 20  TRP 20  16  16  TRP TRP A . n 
A 1 21  SER 21  17  17  SER SER A . n 
A 1 22  GLU 22  18  18  GLU GLU A . n 
A 1 23  LYS 23  19  19  LYS LYS A . n 
A 1 24  GLU 24  20  20  GLU GLU A . n 
A 1 25  LEU 25  21  21  LEU LEU A . n 
A 1 26  LYS 26  22  22  LYS LYS A . n 
A 1 27  GLU 27  23  23  GLU GLU A . n 
A 1 28  LEU 28  24  24  LEU LEU A . n 
A 1 29  PHE 29  25  25  PHE PHE A . n 
A 1 30  GLU 30  26  26  GLU GLU A . n 
A 1 31  PRO 31  27  27  PRO PRO A . n 
A 1 32  TYR 32  28  28  TYR TYR A . n 
A 1 33  GLY 33  29  29  GLY GLY A . n 
A 1 34  ALA 34  30  30  ALA ALA A . n 
A 1 35  VAL 35  31  31  VAL VAL A . n 
A 1 36  TYR 36  32  32  TYR TYR A . n 
A 1 37  GLN 37  33  33  GLN GLN A . n 
A 1 38  ILE 38  34  34  ILE ILE A . n 
A 1 39  ASN 39  35  35  ASN ASN A . n 
A 1 40  VAL 40  36  36  VAL VAL A . n 
A 1 41  LEU 41  37  37  LEU LEU A . n 
A 1 42  ARG 42  38  38  ARG ARG A . n 
A 1 43  ASP 43  39  39  ASP ASP A . n 
A 1 44  ARG 44  40  40  ARG ARG A . n 
A 1 45  SER 45  41  41  SER SER A . n 
A 1 46  GLN 46  42  42  GLN GLN A . n 
A 1 47  ASN 47  43  43  ASN ASN A . n 
A 1 48  PRO 48  44  44  PRO PRO A . n 
A 1 49  PRO 49  45  45  PRO PRO A . n 
A 1 50  GLN 50  46  46  GLN GLN A . n 
A 1 51  SER 51  47  47  SER SER A . n 
A 1 52  LYS 52  48  48  LYS LYS A . n 
A 1 53  GLY 53  49  49  GLY GLY A . n 
A 1 54  CYS 54  50  50  CYS CYS A . n 
A 1 55  CYS 55  51  51  CYS CYS A . n 
A 1 56  PHE 56  52  52  PHE PHE A . n 
A 1 57  VAL 57  53  53  VAL VAL A . n 
A 1 58  THR 58  54  54  THR THR A . n 
A 1 59  PHE 59  55  55  PHE PHE A . n 
A 1 60  TYR 60  56  56  TYR TYR A . n 
A 1 61  THR 61  57  57  THR THR A . n 
A 1 62  ARG 62  58  58  ARG ARG A . n 
A 1 63  LYS 63  59  59  LYS LYS A . n 
A 1 64  ALA 64  60  60  ALA ALA A . n 
A 1 65  ALA 65  61  61  ALA ALA A . n 
A 1 66  LEU 66  62  62  LEU LEU A . n 
A 1 67  GLU 67  63  63  GLU GLU A . n 
A 1 68  ALA 68  64  64  ALA ALA A . n 
A 1 69  GLN 69  65  65  GLN GLN A . n 
A 1 70  ASN 70  66  66  ASN ASN A . n 
A 1 71  ALA 71  67  67  ALA ALA A . n 
A 1 72  LEU 72  68  68  LEU LEU A . n 
A 1 73  HIS 73  69  69  HIS HIS A . n 
A 1 74  ASN 74  70  70  ASN ASN A . n 
A 1 75  ILE 75  71  71  ILE ILE A . n 
A 1 76  LYS 76  72  72  LYS LYS A . n 
A 1 77  THR 77  73  73  THR THR A . n 
A 1 78  LEU 78  74  74  LEU LEU A . n 
A 1 79  PRO 79  75  75  PRO PRO A . n 
A 1 80  GLY 80  76  76  GLY GLY A . n 
A 1 81  MET 81  77  77  MET MET A . n 
A 1 82  HIS 82  78  78  HIS HIS A . n 
A 1 83  HIS 83  79  79  HIS HIS A . n 
A 1 84  PRO 84  80  80  PRO PRO A . n 
A 1 85  ILE 85  81  81  ILE ILE A . n 
A 1 86  GLN 86  82  82  GLN GLN A . n 
A 1 87  MET 87  83  83  MET MET A . n 
A 1 88  LYS 88  84  84  LYS LYS A . n 
A 1 89  PRO 89  85  85  PRO PRO A . n 
A 1 90  ALA 90  86  86  ALA ALA A . n 
A 1 91  ASP 91  87  87  ASP ASP A . n 
A 1 92  SER 92  88  88  SER SER A . n 
A 1 93  GLU 93  89  89  GLU GLU A . n 
A 1 94  LYS 94  90  90  LYS LYS A . n 
A 1 95  SER 95  91  91  SER SER A . n 
A 1 96  ASN 96  92  92  ASN ASN A . n 
A 1 97  ALA 97  93  93  ALA ALA A . n 
A 1 98  VAL 98  94  94  VAL VAL A . n 
A 1 99  GLU 99  95  95  GLU GLU A . n 
A 1 100 ASP 100 96  96  ASP ASP A . n 
A 1 101 ARG 101 97  97  ARG ARG A . n 
A 1 102 LYS 102 98  98  LYS LYS A . n 
A 1 103 LEU 103 99  99  LEU LEU A . n 
A 1 104 PHE 104 100 100 PHE PHE A . n 
A 1 105 ILE 105 101 101 ILE ILE A . n 
A 1 106 GLY 106 102 102 GLY GLY A . n 
A 1 107 MET 107 103 103 MET MET A . n 
A 1 108 VAL 108 104 104 VAL VAL A . n 
A 1 109 SER 109 105 105 SER SER A . n 
A 1 110 LYS 110 106 106 LYS LYS A . n 
A 1 111 LYS 111 107 107 LYS LYS A . n 
A 1 112 CYS 112 108 108 CYS CYS A . n 
A 1 113 ASN 113 109 109 ASN ASN A . n 
A 1 114 GLU 114 110 110 GLU GLU A . n 
A 1 115 ASN 115 111 111 ASN ASN A . n 
A 1 116 ASP 116 112 112 ASP ASP A . n 
A 1 117 ILE 117 113 113 ILE ILE A . n 
A 1 118 ARG 118 114 114 ARG ARG A . n 
A 1 119 VAL 119 115 115 VAL VAL A . n 
A 1 120 MET 120 116 116 MET MET A . n 
A 1 121 PHE 121 117 117 PHE PHE A . n 
A 1 122 SER 122 118 118 SER SER A . n 
A 1 123 PRO 123 119 119 PRO PRO A . n 
A 1 124 PHE 124 120 120 PHE PHE A . n 
A 1 125 GLY 125 121 121 GLY GLY A . n 
A 1 126 GLN 126 122 122 GLN GLN A . n 
A 1 127 ILE 127 123 123 ILE ILE A . n 
A 1 128 GLU 128 124 124 GLU GLU A . n 
A 1 129 GLU 129 125 125 GLU GLU A . n 
A 1 130 CYS 130 126 126 CYS CYS A . n 
A 1 131 ARG 131 127 127 ARG ARG A . n 
A 1 132 ILE 132 128 128 ILE ILE A . n 
A 1 133 LEU 133 129 129 LEU LEU A . n 
A 1 134 ARG 134 130 130 ARG ARG A . n 
A 1 135 GLY 135 131 131 GLY GLY A . n 
A 1 136 PRO 136 132 132 PRO PRO A . n 
A 1 137 ASP 137 133 133 ASP ASP A . n 
A 1 138 GLY 138 134 134 GLY GLY A . n 
A 1 139 LEU 139 135 135 LEU LEU A . n 
A 1 140 SER 140 136 136 SER SER A . n 
A 1 141 ARG 141 137 137 ARG ARG A . n 
A 1 142 GLY 142 138 138 GLY GLY A . n 
A 1 143 CYS 143 139 139 CYS CYS A . n 
A 1 144 ALA 144 140 140 ALA ALA A . n 
A 1 145 PHE 145 141 141 PHE PHE A . n 
A 1 146 VAL 146 142 142 VAL VAL A . n 
A 1 147 THR 147 143 143 THR THR A . n 
A 1 148 PHE 148 144 144 PHE PHE A . n 
A 1 149 SER 149 145 145 SER SER A . n 
A 1 150 THR 150 146 146 THR THR A . n 
A 1 151 ARG 151 147 147 ARG ARG A . n 
A 1 152 ALA 152 148 148 ALA ALA A . n 
A 1 153 MET 153 149 149 MET MET A . n 
A 1 154 ALA 154 150 150 ALA ALA A . n 
A 1 155 GLN 155 151 151 GLN GLN A . n 
A 1 156 ASN 156 152 152 ASN ASN A . n 
A 1 157 ALA 157 153 153 ALA ALA A . n 
A 1 158 ILE 158 154 154 ILE ILE A . n 
A 1 159 LYS 159 155 155 LYS LYS A . n 
A 1 160 ALA 160 156 156 ALA ALA A . n 
A 1 161 MET 161 157 157 MET MET A . n 
A 1 162 HIS 162 158 158 HIS HIS A . n 
A 1 163 GLN 163 159 159 GLN GLN A . n 
A 1 164 SER 164 160 160 SER SER A . n 
A 1 165 GLN 165 161 161 GLN GLN A . n 
A 1 166 THR 166 162 162 THR THR A . n 
A 1 167 MET 167 163 163 MET MET A . n 
A 1 168 GLU 168 164 164 GLU GLU A . n 
A 1 169 GLY 169 165 165 GLY GLY A . n 
A 1 170 CYS 170 166 166 CYS CYS A . n 
A 1 171 SER 171 167 167 SER SER A . n 
A 1 172 SER 172 168 168 SER SER A . n 
A 1 173 PRO 173 169 169 PRO PRO A . n 
A 1 174 ILE 174 170 170 ILE ILE A . n 
A 1 175 VAL 175 171 171 VAL VAL A . n 
A 1 176 VAL 176 172 172 VAL VAL A . n 
A 1 177 LYS 177 173 173 LYS LYS A . n 
A 1 178 PHE 178 174 174 PHE PHE A . n 
A 1 179 ALA 179 175 175 ALA ALA A . n 
A 1 180 ASP 180 176 176 ASP ASP A . n 
B 2 1   DC  1   0   ?   ?   ?   B . n 
B 2 2   DT  2   1   1   DT  DT  B . n 
B 2 3   DG  3   2   2   DG  DG  B . n 
B 2 4   DG  4   3   3   DG  DG  B . n 
B 2 5   DT  5   4   4   DT  DT  B . n 
B 2 6   DC  6   5   5   DC  DC  B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 MG  1  101 1   MG  MG  B . 
D 4 HOH 1  201 47  HOH HOH A . 
D 4 HOH 2  202 123 HOH HOH A . 
D 4 HOH 3  203 7   HOH HOH A . 
D 4 HOH 4  204 59  HOH HOH A . 
D 4 HOH 5  205 86  HOH HOH A . 
D 4 HOH 6  206 127 HOH HOH A . 
D 4 HOH 7  207 22  HOH HOH A . 
D 4 HOH 8  208 15  HOH HOH A . 
D 4 HOH 9  209 65  HOH HOH A . 
D 4 HOH 10 210 128 HOH HOH A . 
D 4 HOH 11 211 44  HOH HOH A . 
D 4 HOH 12 212 31  HOH HOH A . 
D 4 HOH 13 213 54  HOH HOH A . 
D 4 HOH 14 214 120 HOH HOH A . 
D 4 HOH 15 215 122 HOH HOH A . 
D 4 HOH 16 216 53  HOH HOH A . 
D 4 HOH 17 217 18  HOH HOH A . 
D 4 HOH 18 218 89  HOH HOH A . 
D 4 HOH 19 219 4   HOH HOH A . 
D 4 HOH 20 220 66  HOH HOH A . 
D 4 HOH 21 221 103 HOH HOH A . 
D 4 HOH 22 222 12  HOH HOH A . 
D 4 HOH 23 223 23  HOH HOH A . 
D 4 HOH 24 224 51  HOH HOH A . 
D 4 HOH 25 225 2   HOH HOH A . 
D 4 HOH 26 226 69  HOH HOH A . 
D 4 HOH 27 227 99  HOH HOH A . 
D 4 HOH 28 228 58  HOH HOH A . 
D 4 HOH 29 229 3   HOH HOH A . 
D 4 HOH 30 230 92  HOH HOH A . 
D 4 HOH 31 231 36  HOH HOH A . 
D 4 HOH 32 232 21  HOH HOH A . 
D 4 HOH 33 233 50  HOH HOH A . 
D 4 HOH 34 234 119 HOH HOH A . 
D 4 HOH 35 235 34  HOH HOH A . 
D 4 HOH 36 236 39  HOH HOH A . 
D 4 HOH 37 237 33  HOH HOH A . 
D 4 HOH 38 238 116 HOH HOH A . 
D 4 HOH 39 239 17  HOH HOH A . 
D 4 HOH 40 240 71  HOH HOH A . 
D 4 HOH 41 241 70  HOH HOH A . 
D 4 HOH 42 242 83  HOH HOH A . 
D 4 HOH 43 243 52  HOH HOH A . 
D 4 HOH 44 244 42  HOH HOH A . 
D 4 HOH 45 245 30  HOH HOH A . 
D 4 HOH 46 246 61  HOH HOH A . 
D 4 HOH 47 247 35  HOH HOH A . 
D 4 HOH 48 248 56  HOH HOH A . 
D 4 HOH 49 249 100 HOH HOH A . 
D 4 HOH 50 250 8   HOH HOH A . 
D 4 HOH 51 251 6   HOH HOH A . 
D 4 HOH 52 252 46  HOH HOH A . 
D 4 HOH 53 253 78  HOH HOH A . 
D 4 HOH 54 254 110 HOH HOH A . 
D 4 HOH 55 255 60  HOH HOH A . 
D 4 HOH 56 256 28  HOH HOH A . 
D 4 HOH 57 257 19  HOH HOH A . 
D 4 HOH 58 258 40  HOH HOH A . 
D 4 HOH 59 259 48  HOH HOH A . 
D 4 HOH 60 260 29  HOH HOH A . 
D 4 HOH 61 261 5   HOH HOH A . 
D 4 HOH 62 262 84  HOH HOH A . 
D 4 HOH 63 263 82  HOH HOH A . 
D 4 HOH 64 264 11  HOH HOH A . 
D 4 HOH 65 265 16  HOH HOH A . 
D 4 HOH 66 266 20  HOH HOH A . 
D 4 HOH 67 267 64  HOH HOH A . 
D 4 HOH 68 268 41  HOH HOH A . 
D 4 HOH 69 269 27  HOH HOH A . 
D 4 HOH 70 270 49  HOH HOH A . 
D 4 HOH 71 271 10  HOH HOH A . 
D 4 HOH 72 272 91  HOH HOH A . 
D 4 HOH 73 273 68  HOH HOH A . 
D 4 HOH 74 274 37  HOH HOH A . 
D 4 HOH 75 275 26  HOH HOH A . 
D 4 HOH 76 276 88  HOH HOH A . 
D 4 HOH 77 277 112 HOH HOH A . 
D 4 HOH 78 278 97  HOH HOH A . 
D 4 HOH 79 279 109 HOH HOH A . 
D 4 HOH 80 280 87  HOH HOH A . 
D 4 HOH 81 281 111 HOH HOH A . 
D 4 HOH 82 282 125 HOH HOH A . 
D 4 HOH 83 283 77  HOH HOH A . 
D 4 HOH 84 284 107 HOH HOH A . 
D 4 HOH 85 285 115 HOH HOH A . 
D 4 HOH 86 286 38  HOH HOH A . 
D 4 HOH 87 287 75  HOH HOH A . 
D 4 HOH 88 288 102 HOH HOH A . 
D 4 HOH 89 289 126 HOH HOH A . 
D 4 HOH 90 290 55  HOH HOH A . 
D 4 HOH 91 291 95  HOH HOH A . 
D 4 HOH 92 292 118 HOH HOH A . 
D 4 HOH 93 293 124 HOH HOH A . 
D 4 HOH 94 294 85  HOH HOH A . 
D 4 HOH 95 295 108 HOH HOH A . 
E 4 HOH 1  201 9   HOH HOH B . 
E 4 HOH 2  202 45  HOH HOH B . 
E 4 HOH 3  203 81  HOH HOH B . 
E 4 HOH 4  204 114 HOH HOH B . 
E 4 HOH 5  205 94  HOH HOH B . 
E 4 HOH 6  206 62  HOH HOH B . 
E 4 HOH 7  207 96  HOH HOH B . 
E 4 HOH 8  208 76  HOH HOH B . 
E 4 HOH 9  209 129 HOH HOH B . 
E 4 HOH 10 210 105 HOH HOH B . 
E 4 HOH 11 211 14  HOH HOH B . 
E 4 HOH 12 212 117 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.1_5286 ? 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           ? 2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           ? 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           ? 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9URH 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.116 
_cell.length_a_esd                 ? 
_cell.length_b                     70.770 
_cell.length_b_esd                 ? 
_cell.length_c                     134.009 
_cell.length_c_esd                 ? 
_cell.volume                       427871.885 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9URH 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
_symmetry.space_group_name_Hall            'I 2 2' 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9URH 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.43 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.37 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.2 M Magnesium acetate trihydrate, 0.1 M Sodium cacodylate trihydrate pH 6.5, 20% w/v Polyethylene glycol 8,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     80 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M-F' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-01-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.8856 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.8856 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9URH 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.82 
_reflns.d_resolution_low                               37.774 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     19591 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.090 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.823 
_reflns_shell.d_res_low                                     1.854 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             965 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.329 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.787 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.172 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               36.21 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9URH 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.82 
_refine.ls_d_res_low                             37.77 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     19587 
_refine.ls_number_reflns_R_free                  948 
_refine.ls_number_reflns_R_work                  18639 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.85 
_refine.ls_percent_reflns_R_free                 4.84 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1981 
_refine.ls_R_factor_R_free                       0.2213 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1970 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      4LMZ 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.0755 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2247 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.82 
_refine_hist.d_res_low                        37.77 
_refine_hist.number_atoms_solvent             107 
_refine_hist.number_atoms_total               1601 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1389 
_refine_hist.pdbx_number_atoms_nucleic_acid   104 
_refine_hist.pdbx_number_atoms_ligand         1 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0068  ? 1533 ? f_bond_d           ? ? ? 
'X-RAY DIFFRACTION' ? 0.8382  ? 2084 ? f_angle_d          ? ? ? 
'X-RAY DIFFRACTION' ? 0.0610  ? 223  ? f_chiral_restr     ? ? ? 
'X-RAY DIFFRACTION' ? 0.0089  ? 257  ? f_plane_restr      ? ? ? 
'X-RAY DIFFRACTION' ? 18.5752 ? 594  ? f_dihedral_angle_d ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.82 1.92  . . 155 2605 99.96  . . . . 0.2647 . . . . . . . . . . . . . . . 0.3221 
'X-RAY DIFFRACTION' 1.92 2.04  . . 151 2604 99.96  . . . . 0.2274 . . . . . . . . . . . . . . . 0.2660 
'X-RAY DIFFRACTION' 2.04 2.20  . . 120 2643 100.00 . . . . 0.2192 . . . . . . . . . . . . . . . 0.2431 
'X-RAY DIFFRACTION' 2.20 2.42  . . 132 2633 99.89  . . . . 0.2202 . . . . . . . . . . . . . . . 0.2466 
'X-RAY DIFFRACTION' 2.42 2.77  . . 131 2650 99.89  . . . . 0.2279 . . . . . . . . . . . . . . . 0.3074 
'X-RAY DIFFRACTION' 2.77 3.48  . . 131 2702 100.00 . . . . 0.2135 . . . . . . . . . . . . . . . 0.2184 
'X-RAY DIFFRACTION' 3.49 37.77 . . 128 2802 99.32  . . . . 0.1621 . . . . . . . . . . . . . . . 0.1700 
# 
_struct.entry_id                     9URH 
_struct.title                        'Structural insight into DNA recognition by RRM1+2 domain of human ETR-3 protein' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9URH 
_struct_keywords.text            
'Transcription Factor, Protein DNA complex, Human ETR3, Dual DNA and RNA binding, RRM, RNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'RNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CELF2_HUMAN O95319 ? 1 
;DPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHP
IQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQS
QTMEGCSSPIVVKFAD
;
36 
2 PDB 9URH        9URH   ? 2 ? 1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9URH A 5 ? 180 ? O95319 36 ? 211 ? 1 176 
2 2 9URH B 1 ? 6   ? 9URH   0  ? 5   ? 0 5   
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9URH GLY A 1 ? UNP O95319 ? ? 'expression tag' -3 1 
1 9URH SER A 2 ? UNP O95319 ? ? 'expression tag' -2 2 
1 9URH HIS A 3 ? UNP O95319 ? ? 'expression tag' -1 3 
1 9URH MET A 4 ? UNP O95319 ? ? 'expression tag' 0  4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1280  ? 
1 MORE         -11   ? 
1 'SSA (A^2)'  10930 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'NMR relaxation study' 
_pdbx_struct_assembly_auth_evidence.details                'HSQC titration study' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 21  ? GLU A 30  ? SER A 17  GLU A 26  1 ? 10 
HELX_P HELX_P2 AA2 PRO A 31  ? GLY A 33  ? PRO A 27  GLY A 29  5 ? 3  
HELX_P HELX_P3 AA3 THR A 61  ? HIS A 73  ? THR A 57  HIS A 69  1 ? 13 
HELX_P HELX_P4 AA4 ASP A 91  ? LYS A 94  ? ASP A 87  LYS A 90  5 ? 4  
HELX_P HELX_P5 AA5 ALA A 97  ? ASP A 100 ? ALA A 93  ASP A 96  5 ? 4  
HELX_P HELX_P6 AA6 ASN A 113 ? SER A 122 ? ASN A 109 SER A 118 1 ? 10 
HELX_P HELX_P7 AA7 PRO A 123 ? GLY A 125 ? PRO A 119 GLY A 121 5 ? 3  
HELX_P HELX_P8 AA8 THR A 150 ? HIS A 162 ? THR A 146 HIS A 158 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            metalc1 
_struct_conn.conn_type_id                  metalc 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           B 
_struct_conn.ptnr1_label_comp_id           DT 
_struct_conn.ptnr1_label_seq_id            2 
_struct_conn.ptnr1_label_atom_id           OP2 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           C 
_struct_conn.ptnr2_label_comp_id           MG 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           MG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            B 
_struct_conn.ptnr1_auth_comp_id            DT 
_struct_conn.ptnr1_auth_seq_id             1 
_struct_conn.ptnr2_auth_asym_id            B 
_struct_conn.ptnr2_auth_comp_id            MG 
_struct_conn.ptnr2_auth_seq_id             101 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.234 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          ASN 
_struct_mon_prot_cis.label_seq_id           47 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           ASN 
_struct_mon_prot_cis.auth_seq_id            43 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    48 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     44 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -3.94 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 35  ? ASP A 43  ? VAL A 31  ASP A 39  
AA1 2 GLN A 50  ? PHE A 59  ? GLN A 46  PHE A 55  
AA1 3 LYS A 10  ? GLY A 14  ? LYS A 6   GLY A 10  
AA1 4 GLN A 86  ? PRO A 89  ? GLN A 82  PRO A 85  
AA2 1 ILE A 127 ? ARG A 134 ? ILE A 123 ARG A 130 
AA2 2 SER A 140 ? PHE A 148 ? SER A 136 PHE A 144 
AA2 3 LYS A 102 ? GLY A 106 ? LYS A 98  GLY A 102 
AA2 4 VAL A 175 ? PHE A 178 ? VAL A 171 PHE A 174 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASP A 43  ? N ASP A 39  O GLN A 50  ? O GLN A 46  
AA1 2 3 O VAL A 57  ? O VAL A 53  N MET A 11  ? N MET A 7   
AA1 3 4 N PHE A 12  ? N PHE A 8   O LYS A 88  ? O LYS A 84  
AA2 1 2 N LEU A 133 ? N LEU A 129 O ARG A 141 ? O ARG A 137 
AA2 2 3 O VAL A 146 ? O VAL A 142 N LEU A 103 ? N LEU A 99  
AA2 3 4 N PHE A 104 ? N PHE A 100 O LYS A 177 ? O LYS A 173 
# 
_pdbx_entry_details.entry_id                   9URH 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    SER 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     91 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -135.63 
_pdbx_validate_torsion.psi             -36.18 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY -3 ? A GLY 1 
2 1 Y 1 A SER -2 ? A SER 2 
3 1 Y 1 A HIS -1 ? A HIS 3 
4 1 Y 1 B DC  0  ? B DC  1 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CYS N      N  N N 74  
CYS CA     C  N R 75  
CYS C      C  N N 76  
CYS O      O  N N 77  
CYS CB     C  N N 78  
CYS SG     S  N N 79  
CYS OXT    O  N N 80  
CYS H      H  N N 81  
CYS H2     H  N N 82  
CYS HA     H  N N 83  
CYS HB2    H  N N 84  
CYS HB3    H  N N 85  
CYS HG     H  N N 86  
CYS HXT    H  N N 87  
DC  OP3    O  N N 88  
DC  P      P  N N 89  
DC  OP1    O  N N 90  
DC  OP2    O  N N 91  
DC  "O5'"  O  N N 92  
DC  "C5'"  C  N N 93  
DC  "C4'"  C  N R 94  
DC  "O4'"  O  N N 95  
DC  "C3'"  C  N S 96  
DC  "O3'"  O  N N 97  
DC  "C2'"  C  N N 98  
DC  "C1'"  C  N R 99  
DC  N1     N  N N 100 
DC  C2     C  N N 101 
DC  O2     O  N N 102 
DC  N3     N  N N 103 
DC  C4     C  N N 104 
DC  N4     N  N N 105 
DC  C5     C  N N 106 
DC  C6     C  N N 107 
DC  HOP3   H  N N 108 
DC  HOP2   H  N N 109 
DC  "H5'"  H  N N 110 
DC  "H5''" H  N N 111 
DC  "H4'"  H  N N 112 
DC  "H3'"  H  N N 113 
DC  "HO3'" H  N N 114 
DC  "H2'"  H  N N 115 
DC  "H2''" H  N N 116 
DC  "H1'"  H  N N 117 
DC  H41    H  N N 118 
DC  H42    H  N N 119 
DC  H5     H  N N 120 
DC  H6     H  N N 121 
DG  OP3    O  N N 122 
DG  P      P  N N 123 
DG  OP1    O  N N 124 
DG  OP2    O  N N 125 
DG  "O5'"  O  N N 126 
DG  "C5'"  C  N N 127 
DG  "C4'"  C  N R 128 
DG  "O4'"  O  N N 129 
DG  "C3'"  C  N S 130 
DG  "O3'"  O  N N 131 
DG  "C2'"  C  N N 132 
DG  "C1'"  C  N R 133 
DG  N9     N  Y N 134 
DG  C8     C  Y N 135 
DG  N7     N  Y N 136 
DG  C5     C  Y N 137 
DG  C6     C  N N 138 
DG  O6     O  N N 139 
DG  N1     N  N N 140 
DG  C2     C  N N 141 
DG  N2     N  N N 142 
DG  N3     N  N N 143 
DG  C4     C  Y N 144 
DG  HOP3   H  N N 145 
DG  HOP2   H  N N 146 
DG  "H5'"  H  N N 147 
DG  "H5''" H  N N 148 
DG  "H4'"  H  N N 149 
DG  "H3'"  H  N N 150 
DG  "HO3'" H  N N 151 
DG  "H2'"  H  N N 152 
DG  "H2''" H  N N 153 
DG  "H1'"  H  N N 154 
DG  H8     H  N N 155 
DG  H1     H  N N 156 
DG  H21    H  N N 157 
DG  H22    H  N N 158 
DT  OP3    O  N N 159 
DT  P      P  N N 160 
DT  OP1    O  N N 161 
DT  OP2    O  N N 162 
DT  "O5'"  O  N N 163 
DT  "C5'"  C  N N 164 
DT  "C4'"  C  N R 165 
DT  "O4'"  O  N N 166 
DT  "C3'"  C  N S 167 
DT  "O3'"  O  N N 168 
DT  "C2'"  C  N N 169 
DT  "C1'"  C  N R 170 
DT  N1     N  N N 171 
DT  C2     C  N N 172 
DT  O2     O  N N 173 
DT  N3     N  N N 174 
DT  C4     C  N N 175 
DT  O4     O  N N 176 
DT  C5     C  N N 177 
DT  C7     C  N N 178 
DT  C6     C  N N 179 
DT  HOP3   H  N N 180 
DT  HOP2   H  N N 181 
DT  "H5'"  H  N N 182 
DT  "H5''" H  N N 183 
DT  "H4'"  H  N N 184 
DT  "H3'"  H  N N 185 
DT  "HO3'" H  N N 186 
DT  "H2'"  H  N N 187 
DT  "H2''" H  N N 188 
DT  "H1'"  H  N N 189 
DT  H3     H  N N 190 
DT  H71    H  N N 191 
DT  H72    H  N N 192 
DT  H73    H  N N 193 
DT  H6     H  N N 194 
GLN N      N  N N 195 
GLN CA     C  N S 196 
GLN C      C  N N 197 
GLN O      O  N N 198 
GLN CB     C  N N 199 
GLN CG     C  N N 200 
GLN CD     C  N N 201 
GLN OE1    O  N N 202 
GLN NE2    N  N N 203 
GLN OXT    O  N N 204 
GLN H      H  N N 205 
GLN H2     H  N N 206 
GLN HA     H  N N 207 
GLN HB2    H  N N 208 
GLN HB3    H  N N 209 
GLN HG2    H  N N 210 
GLN HG3    H  N N 211 
GLN HE21   H  N N 212 
GLN HE22   H  N N 213 
GLN HXT    H  N N 214 
GLU N      N  N N 215 
GLU CA     C  N S 216 
GLU C      C  N N 217 
GLU O      O  N N 218 
GLU CB     C  N N 219 
GLU CG     C  N N 220 
GLU CD     C  N N 221 
GLU OE1    O  N N 222 
GLU OE2    O  N N 223 
GLU OXT    O  N N 224 
GLU H      H  N N 225 
GLU H2     H  N N 226 
GLU HA     H  N N 227 
GLU HB2    H  N N 228 
GLU HB3    H  N N 229 
GLU HG2    H  N N 230 
GLU HG3    H  N N 231 
GLU HE2    H  N N 232 
GLU HXT    H  N N 233 
GLY N      N  N N 234 
GLY CA     C  N N 235 
GLY C      C  N N 236 
GLY O      O  N N 237 
GLY OXT    O  N N 238 
GLY H      H  N N 239 
GLY H2     H  N N 240 
GLY HA2    H  N N 241 
GLY HA3    H  N N 242 
GLY HXT    H  N N 243 
HIS N      N  N N 244 
HIS CA     C  N S 245 
HIS C      C  N N 246 
HIS O      O  N N 247 
HIS CB     C  N N 248 
HIS CG     C  Y N 249 
HIS ND1    N  Y N 250 
HIS CD2    C  Y N 251 
HIS CE1    C  Y N 252 
HIS NE2    N  Y N 253 
HIS OXT    O  N N 254 
HIS H      H  N N 255 
HIS H2     H  N N 256 
HIS HA     H  N N 257 
HIS HB2    H  N N 258 
HIS HB3    H  N N 259 
HIS HD1    H  N N 260 
HIS HD2    H  N N 261 
HIS HE1    H  N N 262 
HIS HE2    H  N N 263 
HIS HXT    H  N N 264 
HOH O      O  N N 265 
HOH H1     H  N N 266 
HOH H2     H  N N 267 
ILE N      N  N N 268 
ILE CA     C  N S 269 
ILE C      C  N N 270 
ILE O      O  N N 271 
ILE CB     C  N S 272 
ILE CG1    C  N N 273 
ILE CG2    C  N N 274 
ILE CD1    C  N N 275 
ILE OXT    O  N N 276 
ILE H      H  N N 277 
ILE H2     H  N N 278 
ILE HA     H  N N 279 
ILE HB     H  N N 280 
ILE HG12   H  N N 281 
ILE HG13   H  N N 282 
ILE HG21   H  N N 283 
ILE HG22   H  N N 284 
ILE HG23   H  N N 285 
ILE HD11   H  N N 286 
ILE HD12   H  N N 287 
ILE HD13   H  N N 288 
ILE HXT    H  N N 289 
LEU N      N  N N 290 
LEU CA     C  N S 291 
LEU C      C  N N 292 
LEU O      O  N N 293 
LEU CB     C  N N 294 
LEU CG     C  N N 295 
LEU CD1    C  N N 296 
LEU CD2    C  N N 297 
LEU OXT    O  N N 298 
LEU H      H  N N 299 
LEU H2     H  N N 300 
LEU HA     H  N N 301 
LEU HB2    H  N N 302 
LEU HB3    H  N N 303 
LEU HG     H  N N 304 
LEU HD11   H  N N 305 
LEU HD12   H  N N 306 
LEU HD13   H  N N 307 
LEU HD21   H  N N 308 
LEU HD22   H  N N 309 
LEU HD23   H  N N 310 
LEU HXT    H  N N 311 
LYS N      N  N N 312 
LYS CA     C  N S 313 
LYS C      C  N N 314 
LYS O      O  N N 315 
LYS CB     C  N N 316 
LYS CG     C  N N 317 
LYS CD     C  N N 318 
LYS CE     C  N N 319 
LYS NZ     N  N N 320 
LYS OXT    O  N N 321 
LYS H      H  N N 322 
LYS H2     H  N N 323 
LYS HA     H  N N 324 
LYS HB2    H  N N 325 
LYS HB3    H  N N 326 
LYS HG2    H  N N 327 
LYS HG3    H  N N 328 
LYS HD2    H  N N 329 
LYS HD3    H  N N 330 
LYS HE2    H  N N 331 
LYS HE3    H  N N 332 
LYS HZ1    H  N N 333 
LYS HZ2    H  N N 334 
LYS HZ3    H  N N 335 
LYS HXT    H  N N 336 
MET N      N  N N 337 
MET CA     C  N S 338 
MET C      C  N N 339 
MET O      O  N N 340 
MET CB     C  N N 341 
MET CG     C  N N 342 
MET SD     S  N N 343 
MET CE     C  N N 344 
MET OXT    O  N N 345 
MET H      H  N N 346 
MET H2     H  N N 347 
MET HA     H  N N 348 
MET HB2    H  N N 349 
MET HB3    H  N N 350 
MET HG2    H  N N 351 
MET HG3    H  N N 352 
MET HE1    H  N N 353 
MET HE2    H  N N 354 
MET HE3    H  N N 355 
MET HXT    H  N N 356 
MG  MG     MG N N 357 
PHE N      N  N N 358 
PHE CA     C  N S 359 
PHE C      C  N N 360 
PHE O      O  N N 361 
PHE CB     C  N N 362 
PHE CG     C  Y N 363 
PHE CD1    C  Y N 364 
PHE CD2    C  Y N 365 
PHE CE1    C  Y N 366 
PHE CE2    C  Y N 367 
PHE CZ     C  Y N 368 
PHE OXT    O  N N 369 
PHE H      H  N N 370 
PHE H2     H  N N 371 
PHE HA     H  N N 372 
PHE HB2    H  N N 373 
PHE HB3    H  N N 374 
PHE HD1    H  N N 375 
PHE HD2    H  N N 376 
PHE HE1    H  N N 377 
PHE HE2    H  N N 378 
PHE HZ     H  N N 379 
PHE HXT    H  N N 380 
PRO N      N  N N 381 
PRO CA     C  N S 382 
PRO C      C  N N 383 
PRO O      O  N N 384 
PRO CB     C  N N 385 
PRO CG     C  N N 386 
PRO CD     C  N N 387 
PRO OXT    O  N N 388 
PRO H      H  N N 389 
PRO HA     H  N N 390 
PRO HB2    H  N N 391 
PRO HB3    H  N N 392 
PRO HG2    H  N N 393 
PRO HG3    H  N N 394 
PRO HD2    H  N N 395 
PRO HD3    H  N N 396 
PRO HXT    H  N N 397 
SER N      N  N N 398 
SER CA     C  N S 399 
SER C      C  N N 400 
SER O      O  N N 401 
SER CB     C  N N 402 
SER OG     O  N N 403 
SER OXT    O  N N 404 
SER H      H  N N 405 
SER H2     H  N N 406 
SER HA     H  N N 407 
SER HB2    H  N N 408 
SER HB3    H  N N 409 
SER HG     H  N N 410 
SER HXT    H  N N 411 
THR N      N  N N 412 
THR CA     C  N S 413 
THR C      C  N N 414 
THR O      O  N N 415 
THR CB     C  N R 416 
THR OG1    O  N N 417 
THR CG2    C  N N 418 
THR OXT    O  N N 419 
THR H      H  N N 420 
THR H2     H  N N 421 
THR HA     H  N N 422 
THR HB     H  N N 423 
THR HG1    H  N N 424 
THR HG21   H  N N 425 
THR HG22   H  N N 426 
THR HG23   H  N N 427 
THR HXT    H  N N 428 
TRP N      N  N N 429 
TRP CA     C  N S 430 
TRP C      C  N N 431 
TRP O      O  N N 432 
TRP CB     C  N N 433 
TRP CG     C  Y N 434 
TRP CD1    C  Y N 435 
TRP CD2    C  Y N 436 
TRP NE1    N  Y N 437 
TRP CE2    C  Y N 438 
TRP CE3    C  Y N 439 
TRP CZ2    C  Y N 440 
TRP CZ3    C  Y N 441 
TRP CH2    C  Y N 442 
TRP OXT    O  N N 443 
TRP H      H  N N 444 
TRP H2     H  N N 445 
TRP HA     H  N N 446 
TRP HB2    H  N N 447 
TRP HB3    H  N N 448 
TRP HD1    H  N N 449 
TRP HE1    H  N N 450 
TRP HE3    H  N N 451 
TRP HZ2    H  N N 452 
TRP HZ3    H  N N 453 
TRP HH2    H  N N 454 
TRP HXT    H  N N 455 
TYR N      N  N N 456 
TYR CA     C  N S 457 
TYR C      C  N N 458 
TYR O      O  N N 459 
TYR CB     C  N N 460 
TYR CG     C  Y N 461 
TYR CD1    C  Y N 462 
TYR CD2    C  Y N 463 
TYR CE1    C  Y N 464 
TYR CE2    C  Y N 465 
TYR CZ     C  Y N 466 
TYR OH     O  N N 467 
TYR OXT    O  N N 468 
TYR H      H  N N 469 
TYR H2     H  N N 470 
TYR HA     H  N N 471 
TYR HB2    H  N N 472 
TYR HB3    H  N N 473 
TYR HD1    H  N N 474 
TYR HD2    H  N N 475 
TYR HE1    H  N N 476 
TYR HE2    H  N N 477 
TYR HH     H  N N 478 
TYR HXT    H  N N 479 
VAL N      N  N N 480 
VAL CA     C  N S 481 
VAL C      C  N N 482 
VAL O      O  N N 483 
VAL CB     C  N N 484 
VAL CG1    C  N N 485 
VAL CG2    C  N N 486 
VAL OXT    O  N N 487 
VAL H      H  N N 488 
VAL H2     H  N N 489 
VAL HA     H  N N 490 
VAL HB     H  N N 491 
VAL HG11   H  N N 492 
VAL HG12   H  N N 493 
VAL HG13   H  N N 494 
VAL HG21   H  N N 495 
VAL HG22   H  N N 496 
VAL HG23   H  N N 497 
VAL HXT    H  N N 498 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
DC  OP3   P      sing N N 83  
DC  OP3   HOP3   sing N N 84  
DC  P     OP1    doub N N 85  
DC  P     OP2    sing N N 86  
DC  P     "O5'"  sing N N 87  
DC  OP2   HOP2   sing N N 88  
DC  "O5'" "C5'"  sing N N 89  
DC  "C5'" "C4'"  sing N N 90  
DC  "C5'" "H5'"  sing N N 91  
DC  "C5'" "H5''" sing N N 92  
DC  "C4'" "O4'"  sing N N 93  
DC  "C4'" "C3'"  sing N N 94  
DC  "C4'" "H4'"  sing N N 95  
DC  "O4'" "C1'"  sing N N 96  
DC  "C3'" "O3'"  sing N N 97  
DC  "C3'" "C2'"  sing N N 98  
DC  "C3'" "H3'"  sing N N 99  
DC  "O3'" "HO3'" sing N N 100 
DC  "C2'" "C1'"  sing N N 101 
DC  "C2'" "H2'"  sing N N 102 
DC  "C2'" "H2''" sing N N 103 
DC  "C1'" N1     sing N N 104 
DC  "C1'" "H1'"  sing N N 105 
DC  N1    C2     sing N N 106 
DC  N1    C6     sing N N 107 
DC  C2    O2     doub N N 108 
DC  C2    N3     sing N N 109 
DC  N3    C4     doub N N 110 
DC  C4    N4     sing N N 111 
DC  C4    C5     sing N N 112 
DC  N4    H41    sing N N 113 
DC  N4    H42    sing N N 114 
DC  C5    C6     doub N N 115 
DC  C5    H5     sing N N 116 
DC  C6    H6     sing N N 117 
DG  OP3   P      sing N N 118 
DG  OP3   HOP3   sing N N 119 
DG  P     OP1    doub N N 120 
DG  P     OP2    sing N N 121 
DG  P     "O5'"  sing N N 122 
DG  OP2   HOP2   sing N N 123 
DG  "O5'" "C5'"  sing N N 124 
DG  "C5'" "C4'"  sing N N 125 
DG  "C5'" "H5'"  sing N N 126 
DG  "C5'" "H5''" sing N N 127 
DG  "C4'" "O4'"  sing N N 128 
DG  "C4'" "C3'"  sing N N 129 
DG  "C4'" "H4'"  sing N N 130 
DG  "O4'" "C1'"  sing N N 131 
DG  "C3'" "O3'"  sing N N 132 
DG  "C3'" "C2'"  sing N N 133 
DG  "C3'" "H3'"  sing N N 134 
DG  "O3'" "HO3'" sing N N 135 
DG  "C2'" "C1'"  sing N N 136 
DG  "C2'" "H2'"  sing N N 137 
DG  "C2'" "H2''" sing N N 138 
DG  "C1'" N9     sing N N 139 
DG  "C1'" "H1'"  sing N N 140 
DG  N9    C8     sing Y N 141 
DG  N9    C4     sing Y N 142 
DG  C8    N7     doub Y N 143 
DG  C8    H8     sing N N 144 
DG  N7    C5     sing Y N 145 
DG  C5    C6     sing N N 146 
DG  C5    C4     doub Y N 147 
DG  C6    O6     doub N N 148 
DG  C6    N1     sing N N 149 
DG  N1    C2     sing N N 150 
DG  N1    H1     sing N N 151 
DG  C2    N2     sing N N 152 
DG  C2    N3     doub N N 153 
DG  N2    H21    sing N N 154 
DG  N2    H22    sing N N 155 
DG  N3    C4     sing N N 156 
DT  OP3   P      sing N N 157 
DT  OP3   HOP3   sing N N 158 
DT  P     OP1    doub N N 159 
DT  P     OP2    sing N N 160 
DT  P     "O5'"  sing N N 161 
DT  OP2   HOP2   sing N N 162 
DT  "O5'" "C5'"  sing N N 163 
DT  "C5'" "C4'"  sing N N 164 
DT  "C5'" "H5'"  sing N N 165 
DT  "C5'" "H5''" sing N N 166 
DT  "C4'" "O4'"  sing N N 167 
DT  "C4'" "C3'"  sing N N 168 
DT  "C4'" "H4'"  sing N N 169 
DT  "O4'" "C1'"  sing N N 170 
DT  "C3'" "O3'"  sing N N 171 
DT  "C3'" "C2'"  sing N N 172 
DT  "C3'" "H3'"  sing N N 173 
DT  "O3'" "HO3'" sing N N 174 
DT  "C2'" "C1'"  sing N N 175 
DT  "C2'" "H2'"  sing N N 176 
DT  "C2'" "H2''" sing N N 177 
DT  "C1'" N1     sing N N 178 
DT  "C1'" "H1'"  sing N N 179 
DT  N1    C2     sing N N 180 
DT  N1    C6     sing N N 181 
DT  C2    O2     doub N N 182 
DT  C2    N3     sing N N 183 
DT  N3    C4     sing N N 184 
DT  N3    H3     sing N N 185 
DT  C4    O4     doub N N 186 
DT  C4    C5     sing N N 187 
DT  C5    C7     sing N N 188 
DT  C5    C6     doub N N 189 
DT  C7    H71    sing N N 190 
DT  C7    H72    sing N N 191 
DT  C7    H73    sing N N 192 
DT  C6    H6     sing N N 193 
GLN N     CA     sing N N 194 
GLN N     H      sing N N 195 
GLN N     H2     sing N N 196 
GLN CA    C      sing N N 197 
GLN CA    CB     sing N N 198 
GLN CA    HA     sing N N 199 
GLN C     O      doub N N 200 
GLN C     OXT    sing N N 201 
GLN CB    CG     sing N N 202 
GLN CB    HB2    sing N N 203 
GLN CB    HB3    sing N N 204 
GLN CG    CD     sing N N 205 
GLN CG    HG2    sing N N 206 
GLN CG    HG3    sing N N 207 
GLN CD    OE1    doub N N 208 
GLN CD    NE2    sing N N 209 
GLN NE2   HE21   sing N N 210 
GLN NE2   HE22   sing N N 211 
GLN OXT   HXT    sing N N 212 
GLU N     CA     sing N N 213 
GLU N     H      sing N N 214 
GLU N     H2     sing N N 215 
GLU CA    C      sing N N 216 
GLU CA    CB     sing N N 217 
GLU CA    HA     sing N N 218 
GLU C     O      doub N N 219 
GLU C     OXT    sing N N 220 
GLU CB    CG     sing N N 221 
GLU CB    HB2    sing N N 222 
GLU CB    HB3    sing N N 223 
GLU CG    CD     sing N N 224 
GLU CG    HG2    sing N N 225 
GLU CG    HG3    sing N N 226 
GLU CD    OE1    doub N N 227 
GLU CD    OE2    sing N N 228 
GLU OE2   HE2    sing N N 229 
GLU OXT   HXT    sing N N 230 
GLY N     CA     sing N N 231 
GLY N     H      sing N N 232 
GLY N     H2     sing N N 233 
GLY CA    C      sing N N 234 
GLY CA    HA2    sing N N 235 
GLY CA    HA3    sing N N 236 
GLY C     O      doub N N 237 
GLY C     OXT    sing N N 238 
GLY OXT   HXT    sing N N 239 
HIS N     CA     sing N N 240 
HIS N     H      sing N N 241 
HIS N     H2     sing N N 242 
HIS CA    C      sing N N 243 
HIS CA    CB     sing N N 244 
HIS CA    HA     sing N N 245 
HIS C     O      doub N N 246 
HIS C     OXT    sing N N 247 
HIS CB    CG     sing N N 248 
HIS CB    HB2    sing N N 249 
HIS CB    HB3    sing N N 250 
HIS CG    ND1    sing Y N 251 
HIS CG    CD2    doub Y N 252 
HIS ND1   CE1    doub Y N 253 
HIS ND1   HD1    sing N N 254 
HIS CD2   NE2    sing Y N 255 
HIS CD2   HD2    sing N N 256 
HIS CE1   NE2    sing Y N 257 
HIS CE1   HE1    sing N N 258 
HIS NE2   HE2    sing N N 259 
HIS OXT   HXT    sing N N 260 
HOH O     H1     sing N N 261 
HOH O     H2     sing N N 262 
ILE N     CA     sing N N 263 
ILE N     H      sing N N 264 
ILE N     H2     sing N N 265 
ILE CA    C      sing N N 266 
ILE CA    CB     sing N N 267 
ILE CA    HA     sing N N 268 
ILE C     O      doub N N 269 
ILE C     OXT    sing N N 270 
ILE CB    CG1    sing N N 271 
ILE CB    CG2    sing N N 272 
ILE CB    HB     sing N N 273 
ILE CG1   CD1    sing N N 274 
ILE CG1   HG12   sing N N 275 
ILE CG1   HG13   sing N N 276 
ILE CG2   HG21   sing N N 277 
ILE CG2   HG22   sing N N 278 
ILE CG2   HG23   sing N N 279 
ILE CD1   HD11   sing N N 280 
ILE CD1   HD12   sing N N 281 
ILE CD1   HD13   sing N N 282 
ILE OXT   HXT    sing N N 283 
LEU N     CA     sing N N 284 
LEU N     H      sing N N 285 
LEU N     H2     sing N N 286 
LEU CA    C      sing N N 287 
LEU CA    CB     sing N N 288 
LEU CA    HA     sing N N 289 
LEU C     O      doub N N 290 
LEU C     OXT    sing N N 291 
LEU CB    CG     sing N N 292 
LEU CB    HB2    sing N N 293 
LEU CB    HB3    sing N N 294 
LEU CG    CD1    sing N N 295 
LEU CG    CD2    sing N N 296 
LEU CG    HG     sing N N 297 
LEU CD1   HD11   sing N N 298 
LEU CD1   HD12   sing N N 299 
LEU CD1   HD13   sing N N 300 
LEU CD2   HD21   sing N N 301 
LEU CD2   HD22   sing N N 302 
LEU CD2   HD23   sing N N 303 
LEU OXT   HXT    sing N N 304 
LYS N     CA     sing N N 305 
LYS N     H      sing N N 306 
LYS N     H2     sing N N 307 
LYS CA    C      sing N N 308 
LYS CA    CB     sing N N 309 
LYS CA    HA     sing N N 310 
LYS C     O      doub N N 311 
LYS C     OXT    sing N N 312 
LYS CB    CG     sing N N 313 
LYS CB    HB2    sing N N 314 
LYS CB    HB3    sing N N 315 
LYS CG    CD     sing N N 316 
LYS CG    HG2    sing N N 317 
LYS CG    HG3    sing N N 318 
LYS CD    CE     sing N N 319 
LYS CD    HD2    sing N N 320 
LYS CD    HD3    sing N N 321 
LYS CE    NZ     sing N N 322 
LYS CE    HE2    sing N N 323 
LYS CE    HE3    sing N N 324 
LYS NZ    HZ1    sing N N 325 
LYS NZ    HZ2    sing N N 326 
LYS NZ    HZ3    sing N N 327 
LYS OXT   HXT    sing N N 328 
MET N     CA     sing N N 329 
MET N     H      sing N N 330 
MET N     H2     sing N N 331 
MET CA    C      sing N N 332 
MET CA    CB     sing N N 333 
MET CA    HA     sing N N 334 
MET C     O      doub N N 335 
MET C     OXT    sing N N 336 
MET CB    CG     sing N N 337 
MET CB    HB2    sing N N 338 
MET CB    HB3    sing N N 339 
MET CG    SD     sing N N 340 
MET CG    HG2    sing N N 341 
MET CG    HG3    sing N N 342 
MET SD    CE     sing N N 343 
MET CE    HE1    sing N N 344 
MET CE    HE2    sing N N 345 
MET CE    HE3    sing N N 346 
MET OXT   HXT    sing N N 347 
PHE N     CA     sing N N 348 
PHE N     H      sing N N 349 
PHE N     H2     sing N N 350 
PHE CA    C      sing N N 351 
PHE CA    CB     sing N N 352 
PHE CA    HA     sing N N 353 
PHE C     O      doub N N 354 
PHE C     OXT    sing N N 355 
PHE CB    CG     sing N N 356 
PHE CB    HB2    sing N N 357 
PHE CB    HB3    sing N N 358 
PHE CG    CD1    doub Y N 359 
PHE CG    CD2    sing Y N 360 
PHE CD1   CE1    sing Y N 361 
PHE CD1   HD1    sing N N 362 
PHE CD2   CE2    doub Y N 363 
PHE CD2   HD2    sing N N 364 
PHE CE1   CZ     doub Y N 365 
PHE CE1   HE1    sing N N 366 
PHE CE2   CZ     sing Y N 367 
PHE CE2   HE2    sing N N 368 
PHE CZ    HZ     sing N N 369 
PHE OXT   HXT    sing N N 370 
PRO N     CA     sing N N 371 
PRO N     CD     sing N N 372 
PRO N     H      sing N N 373 
PRO CA    C      sing N N 374 
PRO CA    CB     sing N N 375 
PRO CA    HA     sing N N 376 
PRO C     O      doub N N 377 
PRO C     OXT    sing N N 378 
PRO CB    CG     sing N N 379 
PRO CB    HB2    sing N N 380 
PRO CB    HB3    sing N N 381 
PRO CG    CD     sing N N 382 
PRO CG    HG2    sing N N 383 
PRO CG    HG3    sing N N 384 
PRO CD    HD2    sing N N 385 
PRO CD    HD3    sing N N 386 
PRO OXT   HXT    sing N N 387 
SER N     CA     sing N N 388 
SER N     H      sing N N 389 
SER N     H2     sing N N 390 
SER CA    C      sing N N 391 
SER CA    CB     sing N N 392 
SER CA    HA     sing N N 393 
SER C     O      doub N N 394 
SER C     OXT    sing N N 395 
SER CB    OG     sing N N 396 
SER CB    HB2    sing N N 397 
SER CB    HB3    sing N N 398 
SER OG    HG     sing N N 399 
SER OXT   HXT    sing N N 400 
THR N     CA     sing N N 401 
THR N     H      sing N N 402 
THR N     H2     sing N N 403 
THR CA    C      sing N N 404 
THR CA    CB     sing N N 405 
THR CA    HA     sing N N 406 
THR C     O      doub N N 407 
THR C     OXT    sing N N 408 
THR CB    OG1    sing N N 409 
THR CB    CG2    sing N N 410 
THR CB    HB     sing N N 411 
THR OG1   HG1    sing N N 412 
THR CG2   HG21   sing N N 413 
THR CG2   HG22   sing N N 414 
THR CG2   HG23   sing N N 415 
THR OXT   HXT    sing N N 416 
TRP N     CA     sing N N 417 
TRP N     H      sing N N 418 
TRP N     H2     sing N N 419 
TRP CA    C      sing N N 420 
TRP CA    CB     sing N N 421 
TRP CA    HA     sing N N 422 
TRP C     O      doub N N 423 
TRP C     OXT    sing N N 424 
TRP CB    CG     sing N N 425 
TRP CB    HB2    sing N N 426 
TRP CB    HB3    sing N N 427 
TRP CG    CD1    doub Y N 428 
TRP CG    CD2    sing Y N 429 
TRP CD1   NE1    sing Y N 430 
TRP CD1   HD1    sing N N 431 
TRP CD2   CE2    doub Y N 432 
TRP CD2   CE3    sing Y N 433 
TRP NE1   CE2    sing Y N 434 
TRP NE1   HE1    sing N N 435 
TRP CE2   CZ2    sing Y N 436 
TRP CE3   CZ3    doub Y N 437 
TRP CE3   HE3    sing N N 438 
TRP CZ2   CH2    doub Y N 439 
TRP CZ2   HZ2    sing N N 440 
TRP CZ3   CH2    sing Y N 441 
TRP CZ3   HZ3    sing N N 442 
TRP CH2   HH2    sing N N 443 
TRP OXT   HXT    sing N N 444 
TYR N     CA     sing N N 445 
TYR N     H      sing N N 446 
TYR N     H2     sing N N 447 
TYR CA    C      sing N N 448 
TYR CA    CB     sing N N 449 
TYR CA    HA     sing N N 450 
TYR C     O      doub N N 451 
TYR C     OXT    sing N N 452 
TYR CB    CG     sing N N 453 
TYR CB    HB2    sing N N 454 
TYR CB    HB3    sing N N 455 
TYR CG    CD1    doub Y N 456 
TYR CG    CD2    sing Y N 457 
TYR CD1   CE1    sing Y N 458 
TYR CD1   HD1    sing N N 459 
TYR CD2   CE2    doub Y N 460 
TYR CD2   HD2    sing N N 461 
TYR CE1   CZ     doub Y N 462 
TYR CE1   HE1    sing N N 463 
TYR CE2   CZ     sing Y N 464 
TYR CE2   HE2    sing N N 465 
TYR CZ    OH     sing N N 466 
TYR OH    HH     sing N N 467 
TYR OXT   HXT    sing N N 468 
VAL N     CA     sing N N 469 
VAL N     H      sing N N 470 
VAL N     H2     sing N N 471 
VAL CA    C      sing N N 472 
VAL CA    CB     sing N N 473 
VAL CA    HA     sing N N 474 
VAL C     O      doub N N 475 
VAL C     OXT    sing N N 476 
VAL CB    CG1    sing N N 477 
VAL CB    CG2    sing N N 478 
VAL CB    HB     sing N N 479 
VAL CG1   HG11   sing N N 480 
VAL CG1   HG12   sing N N 481 
VAL CG1   HG13   sing N N 482 
VAL CG2   HG21   sing N N 483 
VAL CG2   HG22   sing N N 484 
VAL CG2   HG23   sing N N 485 
VAL OXT   HXT    sing N N 486 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                India 
_pdbx_audit_support.grant_number           'ICGEB New Delhi Core funds' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4LMZ 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9URH 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022165 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014130 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007462 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
MG 12 12 5.4265  2.8275  2.1759 79.2611 1.2283 0.3808  2.3099 7.1937  0.9382   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P  15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2732   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0555   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N     . MET A 1 4   ? 21.03127 30.90811  -23.14876 1.000 49.76149 ? 0   MET A N     1 ? 
ATOM   2    C  CA    . MET A 1 4   ? 19.78417 30.28579  -22.71177 1.000 51.87564 ? 0   MET A CA    1 ? 
ATOM   3    C  C     . MET A 1 4   ? 19.28062 30.92115  -21.42537 1.000 55.15093 ? 0   MET A C     1 ? 
ATOM   4    O  O     . MET A 1 4   ? 20.06509 31.47389  -20.65709 1.000 58.12372 ? 0   MET A O     1 ? 
ATOM   5    C  CB    . MET A 1 4   ? 19.96536 28.77429  -22.51349 1.000 48.77771 ? 0   MET A CB    1 ? 
ATOM   6    C  CG    . MET A 1 4   ? 21.26732 28.38991  -21.83123 1.000 57.42073 ? 0   MET A CG    1 ? 
ATOM   7    S  SD    . MET A 1 4   ? 21.34209 26.64180  -21.35923 1.000 63.34080 ? 0   MET A SD    1 ? 
ATOM   8    C  CE    . MET A 1 4   ? 20.22756 26.61601  -19.96219 1.000 58.68398 ? 0   MET A CE    1 ? 
ATOM   9    N  N     . ASP A 1 5   ? 17.97001 30.83442  -21.19947 1.000 51.80430 ? 1   ASP A N     1 ? 
ATOM   10   C  CA    . ASP A 1 5   ? 17.37169 31.38958  -19.99541 1.000 52.60702 ? 1   ASP A CA    1 ? 
ATOM   11   C  C     . ASP A 1 5   ? 17.88780 30.64936  -18.76269 1.000 54.46279 ? 1   ASP A C     1 ? 
ATOM   12   O  O     . ASP A 1 5   ? 18.28924 29.48490  -18.85055 1.000 54.33022 ? 1   ASP A O     1 ? 
ATOM   13   C  CB    . ASP A 1 5   ? 15.84533 31.29126  -20.04531 1.000 48.89969 ? 1   ASP A CB    1 ? 
ATOM   14   C  CG    . ASP A 1 5   ? 15.22988 32.16872  -21.12165 1.000 53.65820 ? 1   ASP A CG    1 ? 
ATOM   15   O  OD1   . ASP A 1 5   ? 15.98782 32.83982  -21.86193 1.000 54.08629 ? 1   ASP A OD1   1 ? 
ATOM   16   O  OD2   . ASP A 1 5   ? 13.97870 32.17888  -21.22294 1.000 50.77087 ? 1   ASP A OD2   1 ? 
ATOM   17   N  N     . PRO A 1 6   ? 17.89072 31.30513  -17.59625 1.000 56.94112 ? 2   PRO A N     1 ? 
ATOM   18   C  CA    . PRO A 1 6   ? 18.30056 30.61444  -16.36029 1.000 55.59802 ? 2   PRO A CA    1 ? 
ATOM   19   C  C     . PRO A 1 6   ? 17.32000 29.55051  -15.89807 1.000 53.68707 ? 2   PRO A C     1 ? 
ATOM   20   O  O     . PRO A 1 6   ? 17.66727 28.75328  -15.01671 1.000 53.54442 ? 2   PRO A O     1 ? 
ATOM   21   C  CB    . PRO A 1 6   ? 18.39583 31.75381  -15.33606 1.000 51.67664 ? 2   PRO A CB    1 ? 
ATOM   22   C  CG    . PRO A 1 6   ? 17.47129 32.80832  -15.86958 1.000 56.40827 ? 2   PRO A CG    1 ? 
ATOM   23   C  CD    . PRO A 1 6   ? 17.59135 32.72886  -17.36155 1.000 55.82281 ? 2   PRO A CD    1 ? 
ATOM   24   N  N     . ASP A 1 7   ? 16.10901 29.51745  -16.44698 1.000 51.93102 ? 3   ASP A N     1 ? 
ATOM   25   C  CA    . ASP A 1 7   ? 15.13435 28.49039  -16.11286 1.000 50.03117 ? 3   ASP A CA    1 ? 
ATOM   26   C  C     . ASP A 1 7   ? 14.85769 27.55224  -17.28072 1.000 48.61330 ? 3   ASP A C     1 ? 
ATOM   27   O  O     . ASP A 1 7   ? 13.91070 26.76463  -17.21071 1.000 45.91600 ? 3   ASP A O     1 ? 
ATOM   28   C  CB    . ASP A 1 7   ? 13.83001 29.12716  -15.63203 1.000 49.18859 ? 3   ASP A CB    1 ? 
ATOM   29   C  CG    . ASP A 1 7   ? 13.19396 30.01430  -16.68118 1.000 53.02312 ? 3   ASP A CG    1 ? 
ATOM   30   O  OD1   . ASP A 1 7   ? 13.92610 30.49850  -17.57417 1.000 53.94668 ? 3   ASP A OD1   1 ? 
ATOM   31   O  OD2   . ASP A 1 7   ? 11.96099 30.22625  -16.61444 1.000 53.01688 ? 3   ASP A OD2   1 ? 
ATOM   32   N  N     . ALA A 1 8   ? 15.65743 27.62038  -18.35001 1.000 48.58725 ? 4   ALA A N     1 ? 
ATOM   33   C  CA    . ALA A 1 8   ? 15.53238 26.66797  -19.44826 1.000 44.04590 ? 4   ALA A CA    1 ? 
ATOM   34   C  C     . ALA A 1 8   ? 15.61838 25.24384  -18.91878 1.000 42.97286 ? 4   ALA A C     1 ? 
ATOM   35   O  O     . ALA A 1 8   ? 16.17655 24.99595  -17.84513 1.000 44.28074 ? 4   ALA A O     1 ? 
ATOM   36   C  CB    . ALA A 1 8   ? 16.61973 26.90958  -20.49495 1.000 41.03454 ? 4   ALA A CB    1 ? 
ATOM   37   N  N     . ILE A 1 9   ? 15.02926 24.30597  -19.66356 1.000 38.78716 ? 5   ILE A N     1 ? 
ATOM   38   C  CA    . ILE A 1 9   ? 15.02438 22.89040  -19.30204 1.000 39.73103 ? 5   ILE A CA    1 ? 
ATOM   39   C  C     . ILE A 1 9   ? 15.64091 22.09321  -20.44422 1.000 38.80073 ? 5   ILE A C     1 ? 
ATOM   40   O  O     . ILE A 1 9   ? 15.13409 22.12894  -21.57345 1.000 35.96346 ? 5   ILE A O     1 ? 
ATOM   41   C  CB    . ILE A 1 9   ? 13.60825 22.37009  -19.01584 1.000 38.45172 ? 5   ILE A CB    1 ? 
ATOM   42   C  CG1   . ILE A 1 9   ? 12.87917 23.26303  -18.01950 1.000 42.39805 ? 5   ILE A CG1   1 ? 
ATOM   43   C  CG2   . ILE A 1 9   ? 13.66842 20.92838  -18.51687 1.000 39.72684 ? 5   ILE A CG2   1 ? 
ATOM   44   C  CD1   . ILE A 1 9   ? 11.56449 22.68870  -17.58331 1.000 48.42679 ? 5   ILE A CD1   1 ? 
ATOM   45   N  N     . LYS A 1 10  ? 16.70691 21.34849  -20.15316 1.000 31.08611 ? 6   LYS A N     1 ? 
ATOM   46   C  CA    . LYS A 1 10  ? 17.16741 20.36005  -21.12164 1.000 31.01100 ? 6   LYS A CA    1 ? 
ATOM   47   C  C     . LYS A 1 10  ? 16.18859 19.19128  -21.14583 1.000 30.50407 ? 6   LYS A C     1 ? 
ATOM   48   O  O     . LYS A 1 10  ? 15.86026 18.62139  -20.10076 1.000 31.73707 ? 6   LYS A O     1 ? 
ATOM   49   C  CB    . LYS A 1 10  ? 18.57228 19.87396  -20.77591 1.000 31.72842 ? 6   LYS A CB    1 ? 
ATOM   50   C  CG    . LYS A 1 10  ? 19.07780 18.79416  -21.73155 1.000 32.65569 ? 6   LYS A CG    1 ? 
ATOM   51   C  CD    . LYS A 1 10  ? 20.60246 18.66033  -21.69104 1.000 36.63087 ? 6   LYS A CD    1 ? 
ATOM   52   C  CE    . LYS A 1 10  ? 21.06104 17.87185  -20.49141 1.000 37.83581 ? 6   LYS A CE    1 ? 
ATOM   53   N  NZ    . LYS A 1 10  ? 22.56448 17.84457  -20.39695 1.000 39.92622 ? 6   LYS A NZ    1 ? 
ATOM   54   N  N     . MET A 1 11  ? 15.71264 18.83013  -22.33341 1.000 28.75307 ? 7   MET A N     1 ? 
ATOM   55   C  CA    . MET A 1 11  ? 14.72218 17.77282  -22.48005 1.000 25.92894 ? 7   MET A CA    1 ? 
ATOM   56   C  C     . MET A 1 11  ? 15.36661 16.53584  -23.08067 1.000 24.22873 ? 7   MET A C     1 ? 
ATOM   57   O  O     . MET A 1 11  ? 16.16660 16.63641  -24.00893 1.000 24.67902 ? 7   MET A O     1 ? 
ATOM   58   C  CB    . MET A 1 11  ? 13.56513 18.20501  -23.38260 1.000 27.74684 ? 7   MET A CB    1 ? 
ATOM   59   C  CG    . MET A 1 11  ? 12.65280 19.26817  -22.75773 1.000 30.45288 ? 7   MET A CG    1 ? 
ATOM   60   S  SD    . MET A 1 11  ? 11.55059 18.48235  -21.56830 1.000 35.59502 ? 7   MET A SD    1 ? 
ATOM   61   C  CE    . MET A 1 11  ? 10.53548 19.87575  -21.04555 1.000 33.95275 ? 7   MET A CE    1 ? 
ATOM   62   N  N     . PHE A 1 12  ? 14.98680 15.37803  -22.56881 1.000 23.22649 ? 8   PHE A N     1 ? 
ATOM   63   C  CA    . PHE A 1 12  ? 15.33992 14.10035  -23.17343 1.000 26.86420 ? 8   PHE A CA    1 ? 
ATOM   64   C  C     . PHE A 1 12  ? 14.23945 13.69343  -24.14497 1.000 27.68323 ? 8   PHE A C     1 ? 
ATOM   65   O  O     . PHE A 1 12  ? 13.06008 13.75919  -23.80478 1.000 28.10683 ? 8   PHE A O     1 ? 
ATOM   66   C  CB    . PHE A 1 12  ? 15.50217 13.03528  -22.09280 1.000 26.67616 ? 8   PHE A CB    1 ? 
ATOM   67   C  CG    . PHE A 1 12  ? 15.68817 11.65063  -22.62983 1.000 25.62031 ? 8   PHE A CG    1 ? 
ATOM   68   C  CD1   . PHE A 1 12  ? 16.95240 11.19614  -22.99761 1.000 26.88572 ? 8   PHE A CD1   1 ? 
ATOM   69   C  CD2   . PHE A 1 12  ? 14.61059 10.79341  -22.74694 1.000 27.23790 ? 8   PHE A CD2   1 ? 
ATOM   70   C  CE1   . PHE A 1 12  ? 17.11958 9.91033   -23.48811 1.000 26.88772 ? 8   PHE A CE1   1 ? 
ATOM   71   C  CE2   . PHE A 1 12  ? 14.77549 9.50740   -23.23802 1.000 29.92253 ? 8   PHE A CE2   1 ? 
ATOM   72   C  CZ    . PHE A 1 12  ? 16.03565 9.06866   -23.60172 1.000 26.35645 ? 8   PHE A CZ    1 ? 
ATOM   73   N  N     . VAL A 1 13  ? 14.62205 13.25874  -25.34332 1.000 25.26993 ? 9   VAL A N     1 ? 
ATOM   74   C  CA    . VAL A 1 13  ? 13.66328 12.85540  -26.36933 1.000 26.35738 ? 9   VAL A CA    1 ? 
ATOM   75   C  C     . VAL A 1 13  ? 14.02499 11.45822  -26.83096 1.000 26.22349 ? 9   VAL A C     1 ? 
ATOM   76   O  O     . VAL A 1 13  ? 15.15233 11.23617  -27.28451 1.000 28.45151 ? 9   VAL A O     1 ? 
ATOM   77   C  CB    . VAL A 1 13  ? 13.66420 13.82835  -27.56063 1.000 27.05010 ? 9   VAL A CB    1 ? 
ATOM   78   C  CG1   . VAL A 1 13  ? 12.46371 13.58836  -28.44304 1.000 26.95476 ? 9   VAL A CG1   1 ? 
ATOM   79   C  CG2   . VAL A 1 13  ? 13.71792 15.23064  -27.03803 1.000 24.01997 ? 9   VAL A CG2   1 ? 
ATOM   80   N  N     . GLY A 1 14  ? 13.07283 10.51999  -26.72157 1.000 24.96540 ? 10  GLY A N     1 ? 
ATOM   81   C  CA    . GLY A 1 14  ? 13.25721 9.15465   -27.16401 1.000 26.38732 ? 10  GLY A CA    1 ? 
ATOM   82   C  C     . GLY A 1 14  ? 12.37522 8.81277   -28.35867 1.000 28.49985 ? 10  GLY A C     1 ? 
ATOM   83   O  O     . GLY A 1 14  ? 11.49882 9.58206   -28.75166 1.000 28.79687 ? 10  GLY A O     1 ? 
ATOM   84   N  N     . GLN A 1 15  ? 12.64075 7.63086   -28.93672 1.000 24.95001 ? 11  GLN A N     1 ? 
ATOM   85   C  CA    . GLN A 1 15  ? 11.96609 7.12808   -30.14282 1.000 26.14578 ? 11  GLN A CA    1 ? 
ATOM   86   C  C     . GLN A 1 15  ? 12.31622 7.98336   -31.36180 1.000 29.44164 ? 11  GLN A C     1 ? 
ATOM   87   O  O     . GLN A 1 15  ? 11.48152 8.24636   -32.22561 1.000 28.19267 ? 11  GLN A O     1 ? 
ATOM   88   C  CB    . GLN A 1 15  ? 10.44855 7.02804   -29.95941 1.000 28.98472 ? 11  GLN A CB    1 ? 
ATOM   89   C  CG    . GLN A 1 15  ? 10.04615 5.99756   -28.92636 1.000 31.35087 ? 11  GLN A CG    1 ? 
ATOM   90   C  CD    . GLN A 1 15  ? 10.47952 4.58385   -29.30932 1.000 34.83642 ? 11  GLN A CD    1 ? 
ATOM   91   O  OE1   . GLN A 1 15  ? 10.15885 4.08473   -30.39254 1.000 35.33783 ? 11  GLN A OE1   1 ? 
ATOM   92   N  NE2   . GLN A 1 15  ? 11.24235 3.95288   -28.43439 1.000 37.28804 ? 11  GLN A NE2   1 ? 
ATOM   93   N  N     . ILE A 1 16  ? 13.56960 8.41161   -31.42502 1.000 26.23400 ? 12  ILE A N     1 ? 
ATOM   94   C  CA    . ILE A 1 16  ? 14.13453 9.08072   -32.59398 1.000 26.03386 ? 12  ILE A CA    1 ? 
ATOM   95   C  C     . ILE A 1 16  ? 14.72055 8.00560   -33.49744 1.000 27.59148 ? 12  ILE A C     1 ? 
ATOM   96   O  O     . ILE A 1 16  ? 15.44723 7.13181   -32.99974 1.000 29.84556 ? 12  ILE A O     1 ? 
ATOM   97   C  CB    . ILE A 1 16  ? 15.22897 10.08115  -32.18375 1.000 26.65114 ? 12  ILE A CB    1 ? 
ATOM   98   C  CG1   . ILE A 1 16  ? 14.70752 11.11387  -31.16004 1.000 25.46918 ? 12  ILE A CG1   1 ? 
ATOM   99   C  CG2   . ILE A 1 16  ? 15.85564 10.72512  -33.41295 1.000 25.91803 ? 12  ILE A CG2   1 ? 
ATOM   100  C  CD1   . ILE A 1 16  ? 13.71112 12.11263  -31.69997 1.000 30.69361 ? 12  ILE A CD1   1 ? 
ATOM   101  N  N     . PRO A 1 17  ? 14.48988 8.03288   -34.80693 1.000 28.29896 ? 13  PRO A N     1 ? 
ATOM   102  C  CA    . PRO A 1 17  ? 15.17941 7.07967   -35.68736 1.000 27.27786 ? 13  PRO A CA    1 ? 
ATOM   103  C  C     . PRO A 1 17  ? 16.69559 7.11337   -35.48482 1.000 30.10835 ? 13  PRO A C     1 ? 
ATOM   104  O  O     . PRO A 1 17  ? 17.30649 8.17558   -35.43924 1.000 27.35487 ? 13  PRO A O     1 ? 
ATOM   105  C  CB    . PRO A 1 17  ? 14.78817 7.55718   -37.09031 1.000 29.24450 ? 13  PRO A CB    1 ? 
ATOM   106  C  CG    . PRO A 1 17  ? 13.47494 8.27071   -36.89450 1.000 29.41221 ? 13  PRO A CG    1 ? 
ATOM   107  C  CD    . PRO A 1 17  ? 13.59030 8.93623   -35.55532 1.000 28.78872 ? 13  PRO A CD    1 ? 
ATOM   108  N  N     . ARG A 1 18  ? 17.31060 5.92670   -35.36512 1.000 30.35197 ? 14  ARG A N     1 ? 
ATOM   109  C  CA    . ARG A 1 18  ? 18.77429 5.84958   -35.25543 1.000 27.24473 ? 14  ARG A CA    1 ? 
ATOM   110  C  C     . ARG A 1 18  ? 19.48711 6.51067   -36.42487 1.000 27.70695 ? 14  ARG A C     1 ? 
ATOM   111  O  O     . ARG A 1 18  ? 20.63836 6.94208   -36.28574 1.000 28.34467 ? 14  ARG A O     1 ? 
ATOM   112  C  CB    . ARG A 1 18  ? 19.22435 4.39310   -35.19000 1.000 30.65290 ? 14  ARG A CB    1 ? 
ATOM   113  C  CG    . ARG A 1 18  ? 19.18067 3.79632   -33.85205 1.000 31.06355 ? 14  ARG A CG    1 ? 
ATOM   114  C  CD    . ARG A 1 18  ? 19.69124 2.36484   -33.95194 1.000 30.50883 ? 14  ARG A CD    1 ? 
ATOM   115  N  NE    . ARG A 1 18  ? 18.93407 1.50254   -33.06481 1.000 35.75242 ? 14  ARG A NE    1 ? 
ATOM   116  C  CZ    . ARG A 1 18  ? 19.15162 1.42633   -31.76103 1.000 37.74021 ? 14  ARG A CZ    1 ? 
ATOM   117  N  NH1   . ARG A 1 18  ? 20.04617 2.20381   -31.16283 1.000 36.03561 ? 14  ARG A NH1   1 ? 
ATOM   118  N  NH2   . ARG A 1 18  ? 18.47388 0.53714   -31.04344 1.000 36.61436 ? 14  ARG A NH2   1 ? 
ATOM   119  N  N     . SER A 1 19  ? 18.84683 6.56507   -37.59850 1.000 29.06299 ? 15  SER A N     1 ? 
ATOM   120  C  CA    . SER A 1 19  ? 19.49533 7.16310   -38.75959 1.000 30.17300 ? 15  SER A CA    1 ? 
ATOM   121  C  C     . SER A 1 19  ? 19.55595 8.68166   -38.67368 1.000 32.31048 ? 15  SER A C     1 ? 
ATOM   122  O  O     . SER A 1 19  ? 20.35365 9.29821   -39.38773 1.000 35.70297 ? 15  SER A O     1 ? 
ATOM   123  C  CB    . SER A 1 19  ? 18.76970 6.75745   -40.04183 1.000 33.27098 ? 15  SER A CB    1 ? 
ATOM   124  O  OG    . SER A 1 19  ? 17.49589 7.38002   -40.10002 1.000 35.71980 ? 15  SER A OG    1 ? 
ATOM   125  N  N     . TRP A 1 20  ? 18.73976 9.29400   -37.82251 1.000 29.42818 ? 16  TRP A N     1 ? 
ATOM   126  C  CA    . TRP A 1 20  ? 18.72945 10.74306  -37.69640 1.000 27.76257 ? 16  TRP A CA    1 ? 
ATOM   127  C  C     . TRP A 1 20  ? 19.97038 11.24652  -36.97545 1.000 29.79206 ? 16  TRP A C     1 ? 
ATOM   128  O  O     . TRP A 1 20  ? 20.53188 10.57932  -36.09928 1.000 29.80666 ? 16  TRP A O     1 ? 
ATOM   129  C  CB    . TRP A 1 20  ? 17.49223 11.21308  -36.93057 1.000 28.85091 ? 16  TRP A CB    1 ? 
ATOM   130  C  CG    . TRP A 1 20  ? 16.26123 11.27924  -37.76602 1.000 29.51352 ? 16  TRP A CG    1 ? 
ATOM   131  C  CD1   . TRP A 1 20  ? 16.00440 10.57809  -38.90990 1.000 30.90258 ? 16  TRP A CD1   1 ? 
ATOM   132  C  CD2   . TRP A 1 20  ? 15.11833 12.10484  -37.53038 1.000 26.59263 ? 16  TRP A CD2   1 ? 
ATOM   133  N  NE1   . TRP A 1 20  ? 14.75922 10.92456  -39.40197 1.000 27.61873 ? 16  TRP A NE1   1 ? 
ATOM   134  C  CE2   . TRP A 1 20  ? 14.19947 11.85652  -38.56961 1.000 31.63938 ? 16  TRP A CE2   1 ? 
ATOM   135  C  CE3   . TRP A 1 20  ? 14.78480 13.03559  -36.54451 1.000 27.90045 ? 16  TRP A CE3   1 ? 
ATOM   136  C  CZ2   . TRP A 1 20  ? 12.96740 12.50476  -38.64889 1.000 29.86034 ? 16  TRP A CZ2   1 ? 
ATOM   137  C  CZ3   . TRP A 1 20  ? 13.55280 13.67512  -36.62231 1.000 26.99266 ? 16  TRP A CZ3   1 ? 
ATOM   138  C  CH2   . TRP A 1 20  ? 12.66538 13.40437  -37.66771 1.000 29.47079 ? 16  TRP A CH2   1 ? 
ATOM   139  N  N     . SER A 1 21  ? 20.38184 12.44376  -37.34680 1.000 28.98143 ? 17  SER A N     1 ? 
ATOM   140  C  CA    . SER A 1 21  ? 21.39475 13.19014  -36.62233 1.000 28.88863 ? 17  SER A CA    1 ? 
ATOM   141  C  C     . SER A 1 21  ? 20.79339 14.51593  -36.16988 1.000 27.87705 ? 17  SER A C     1 ? 
ATOM   142  O  O     . SER A 1 21  ? 19.60081 14.78129  -36.33894 1.000 27.58188 ? 17  SER A O     1 ? 
ATOM   143  C  CB    . SER A 1 21  ? 22.62863 13.42370  -37.49656 1.000 30.77974 ? 17  SER A CB    1 ? 
ATOM   144  O  OG    . SER A 1 21  ? 22.37586 14.49855  -38.40402 1.000 32.38037 ? 17  SER A OG    1 ? 
ATOM   145  N  N     . GLU A 1 22  ? 21.65459 15.37067  -35.62161 1.000 27.03476 ? 18  GLU A N     1 ? 
ATOM   146  C  CA    . GLU A 1 22  ? 21.23556 16.68497  -35.17701 1.000 26.28996 ? 18  GLU A CA    1 ? 
ATOM   147  C  C     . GLU A 1 22  ? 20.60872 17.50498  -36.30610 1.000 26.77696 ? 18  GLU A C     1 ? 
ATOM   148  O  O     . GLU A 1 22  ? 19.79372 18.39583  -36.03057 1.000 27.29706 ? 18  GLU A O     1 ? 
ATOM   149  C  CB    . GLU A 1 22  ? 22.45024 17.38278  -34.54440 1.000 29.02520 ? 18  GLU A CB    1 ? 
ATOM   150  C  CG    . GLU A 1 22  ? 22.88912 16.76144  -33.16356 1.000 29.47214 ? 18  GLU A CG    1 ? 
ATOM   151  C  CD    . GLU A 1 22  ? 23.82567 15.52393  -33.23446 1.000 32.08089 ? 18  GLU A CD    1 ? 
ATOM   152  O  OE1   . GLU A 1 22  ? 24.07219 14.97138  -34.34180 1.000 28.37959 ? 18  GLU A OE1   1 ? 
ATOM   153  O  OE2   . GLU A 1 22  ? 24.33592 15.10292  -32.15483 1.000 25.78438 ? 18  GLU A OE2   1 ? 
ATOM   154  N  N     . LYS A 1 23  ? 20.91823 17.18937  -37.56665 1.000 27.56281 ? 19  LYS A N     1 ? 
ATOM   155  C  CA    . LYS A 1 23  ? 20.35775 17.95389  -38.68190 1.000 30.21989 ? 19  LYS A CA    1 ? 
ATOM   156  C  C     . LYS A 1 23  ? 18.84918 17.78571  -38.76605 1.000 30.87047 ? 19  LYS A C     1 ? 
ATOM   157  O  O     . LYS A 1 23  ? 18.10601 18.77191  -38.82791 1.000 30.32496 ? 19  LYS A O     1 ? 
ATOM   158  C  CB    . LYS A 1 23  ? 20.99352 17.53213  -40.00780 1.000 34.12361 ? 19  LYS A CB    1 ? 
ATOM   159  C  CG    . LYS A 1 23  ? 20.41401 18.32079  -41.19598 1.000 39.19658 ? 19  LYS A CG    1 ? 
ATOM   160  C  CD    . LYS A 1 23  ? 21.14218 18.04323  -42.50544 1.000 47.98835 ? 19  LYS A CD    1 ? 
ATOM   161  C  CE    . LYS A 1 23  ? 20.23569 17.34060  -43.51864 1.000 58.20452 ? 19  LYS A CE    1 ? 
ATOM   162  N  NZ    . LYS A 1 23  ? 20.19119 15.85178  -43.32823 1.000 59.92398 ? 19  LYS A NZ    1 ? 
ATOM   163  N  N     . GLU A 1 24  ? 18.37811 16.53903  -38.77928 1.000 29.34725 ? 20  GLU A N     1 ? 
ATOM   164  C  CA    . GLU A 1 24  ? 16.93896 16.29742  -38.81409 1.000 27.70129 ? 20  GLU A CA    1 ? 
ATOM   165  C  C     . GLU A 1 24  ? 16.26015 16.78532  -37.54473 1.000 27.09173 ? 20  GLU A C     1 ? 
ATOM   166  O  O     . GLU A 1 24  ? 15.10442 17.23166  -37.58073 1.000 26.23817 ? 20  GLU A O     1 ? 
ATOM   167  C  CB    . GLU A 1 24  ? 16.66782 14.80177  -39.00967 1.000 30.24263 ? 20  GLU A CB    1 ? 
ATOM   168  C  CG    . GLU A 1 24  ? 16.98748 14.27166  -40.39550 1.000 34.89354 ? 20  GLU A CG    1 ? 
ATOM   169  C  CD    . GLU A 1 24  ? 18.39845 13.70184  -40.53995 1.000 39.29873 ? 20  GLU A CD    1 ? 
ATOM   170  O  OE1   . GLU A 1 24  ? 19.26363 13.90105  -39.63975 1.000 36.48395 ? 20  GLU A OE1   1 ? 
ATOM   171  O  OE2   . GLU A 1 24  ? 18.63932 13.04408  -41.57901 1.000 44.97350 ? 20  GLU A OE2   1 ? 
ATOM   172  N  N     . LEU A 1 25  ? 16.95291 16.69847  -36.40893 1.000 24.60150 ? 21  LEU A N     1 ? 
ATOM   173  C  CA    . LEU A 1 25  ? 16.33852 17.07814  -35.14585 1.000 21.29811 ? 21  LEU A CA    1 ? 
ATOM   174  C  C     . LEU A 1 25  ? 16.17556 18.57966  -35.05863 1.000 23.67120 ? 21  LEU A C     1 ? 
ATOM   175  O  O     . LEU A 1 25  ? 15.22241 19.06558  -34.44988 1.000 24.11872 ? 21  LEU A O     1 ? 
ATOM   176  C  CB    . LEU A 1 25  ? 17.18730 16.56745  -33.98144 1.000 23.04593 ? 21  LEU A CB    1 ? 
ATOM   177  C  CG    . LEU A 1 25  ? 17.13750 15.04140  -33.88078 1.000 24.71995 ? 21  LEU A CG    1 ? 
ATOM   178  C  CD1   . LEU A 1 25  ? 18.23081 14.55109  -32.93931 1.000 26.09751 ? 21  LEU A CD1   1 ? 
ATOM   179  C  CD2   . LEU A 1 25  ? 15.76203 14.62101  -33.39413 1.000 23.78231 ? 21  LEU A CD2   1 ? 
ATOM   180  N  N     . LYS A 1 26  ? 17.10572 19.31606  -35.65779 1.000 25.67890 ? 22  LYS A N     1 ? 
ATOM   181  C  CA    . LYS A 1 26  ? 16.98265 20.76360  -35.73159 1.000 26.82975 ? 22  LYS A CA    1 ? 
ATOM   182  C  C     . LYS A 1 26  ? 15.71455 21.15834  -36.47836 1.000 28.00503 ? 22  LYS A C     1 ? 
ATOM   183  O  O     . LYS A 1 26  ? 14.96817 22.03550  -36.03147 1.000 29.31678 ? 22  LYS A O     1 ? 
ATOM   184  C  CB    . LYS A 1 26  ? 18.23161 21.33066  -36.40274 1.000 31.16851 ? 22  LYS A CB    1 ? 
ATOM   185  C  CG    . LYS A 1 26  ? 18.38912 22.82706  -36.23975 1.000 36.68682 ? 22  LYS A CG    1 ? 
ATOM   186  C  CD    . LYS A 1 26  ? 19.77386 23.25720  -36.69314 1.000 38.29673 ? 22  LYS A CD    1 ? 
ATOM   187  C  CE    . LYS A 1 26  ? 19.70345 24.24722  -37.84333 1.000 44.13016 ? 22  LYS A CE    1 ? 
ATOM   188  N  NZ    . LYS A 1 26  ? 19.46030 25.63048  -37.36085 1.000 44.68295 ? 22  LYS A NZ    1 ? 
ATOM   189  N  N     . GLU A 1 27  ? 15.42651 20.48319  -37.59533 1.000 29.31176 ? 23  GLU A N     1 ? 
ATOM   190  C  CA    . GLU A 1 27  ? 14.20506 20.78074  -38.33598 1.000 28.38556 ? 23  GLU A CA    1 ? 
ATOM   191  C  C     . GLU A 1 27  ? 12.96426 20.37910  -37.55739 1.000 28.71209 ? 23  GLU A C     1 ? 
ATOM   192  O  O     . GLU A 1 27  ? 11.91598 21.01922  -37.69346 1.000 30.94222 ? 23  GLU A O     1 ? 
ATOM   193  C  CB    . GLU A 1 27  ? 14.22646 20.08250  -39.69193 1.000 33.42470 ? 23  GLU A CB    1 ? 
ATOM   194  C  CG    . GLU A 1 27  ? 15.33297 20.56510  -40.60129 1.000 38.93296 ? 23  GLU A CG    1 ? 
ATOM   195  C  CD    . GLU A 1 27  ? 15.73852 19.52835  -41.63768 1.000 47.15464 ? 23  GLU A CD    1 ? 
ATOM   196  O  OE1   . GLU A 1 27  ? 15.10295 18.44596  -41.68232 1.000 51.92398 ? 23  GLU A OE1   1 ? 
ATOM   197  O  OE2   . GLU A 1 27  ? 16.69795 19.79641  -42.40128 1.000 53.50644 ? 23  GLU A OE2   1 ? 
ATOM   198  N  N     . LEU A 1 28  ? 13.04856 19.32500  -36.74081 1.000 26.44512 ? 24  LEU A N     1 ? 
ATOM   199  C  CA    . LEU A 1 28  ? 11.88647 18.92432  -35.95319 1.000 23.77775 ? 24  LEU A CA    1 ? 
ATOM   200  C  C     . LEU A 1 28  ? 11.56771 19.93819  -34.85888 1.000 26.41642 ? 24  LEU A C     1 ? 
ATOM   201  O  O     . LEU A 1 28  ? 10.39977 20.29040  -34.64770 1.000 27.35038 ? 24  LEU A O     1 ? 
ATOM   202  C  CB    . LEU A 1 28  ? 12.13048 17.54230  -35.33109 1.000 24.27106 ? 24  LEU A CB    1 ? 
ATOM   203  C  CG    . LEU A 1 28  ? 11.06281 17.06026  -34.35699 1.000 26.80727 ? 24  LEU A CG    1 ? 
ATOM   204  C  CD1   . LEU A 1 28  ? 9.76713  16.74802  -35.10445 1.000 27.30630 ? 24  LEU A CD1   1 ? 
ATOM   205  C  CD2   . LEU A 1 28  ? 11.55344 15.81487  -33.60324 1.000 28.89289 ? 24  LEU A CD2   1 ? 
ATOM   206  N  N     . PHE A 1 29  ? 12.58935 20.40762  -34.14414 1.000 23.97694 ? 25  PHE A N     1 ? 
ATOM   207  C  CA    . PHE A 1 29  ? 12.39589 21.17563  -32.91782 1.000 22.57018 ? 25  PHE A CA    1 ? 
ATOM   208  C  C     . PHE A 1 29  ? 12.29035 22.68387  -33.12715 1.000 23.93202 ? 25  PHE A C     1 ? 
ATOM   209  O  O     . PHE A 1 29  ? 11.58741 23.35569  -32.36841 1.000 25.70410 ? 25  PHE A O     1 ? 
ATOM   210  C  CB    . PHE A 1 29  ? 13.56647 20.91626  -31.97336 1.000 22.01719 ? 25  PHE A CB    1 ? 
ATOM   211  C  CG    . PHE A 1 29  ? 13.59525 19.52295  -31.42636 1.000 22.91329 ? 25  PHE A CG    1 ? 
ATOM   212  C  CD1   . PHE A 1 29  ? 12.45879 18.97610  -30.87569 1.000 25.37963 ? 25  PHE A CD1   1 ? 
ATOM   213  C  CD2   . PHE A 1 29  ? 14.75804 18.77253  -31.45689 1.000 28.15208 ? 25  PHE A CD2   1 ? 
ATOM   214  C  CE1   . PHE A 1 29  ? 12.47854 17.67918  -30.35276 1.000 26.38606 ? 25  PHE A CE1   1 ? 
ATOM   215  C  CE2   . PHE A 1 29  ? 14.77601 17.47416  -30.93404 1.000 26.14385 ? 25  PHE A CE2   1 ? 
ATOM   216  C  CZ    . PHE A 1 29  ? 13.63395 16.94818  -30.39398 1.000 25.86935 ? 25  PHE A CZ    1 ? 
ATOM   217  N  N     . GLU A 1 30  ? 13.02077 23.24440  -34.08445 1.000 24.49992 ? 26  GLU A N     1 ? 
ATOM   218  C  CA    . GLU A 1 30  ? 13.02322 24.69844  -34.21750 1.000 28.29241 ? 26  GLU A CA    1 ? 
ATOM   219  C  C     . GLU A 1 30  ? 11.64839 25.32616  -34.48009 1.000 30.01241 ? 26  GLU A C     1 ? 
ATOM   220  O  O     . GLU A 1 30  ? 11.45881 26.48348  -34.06741 1.000 27.49106 ? 26  GLU A O     1 ? 
ATOM   221  C  CB    . GLU A 1 30  ? 14.03277 25.10809  -35.29554 1.000 27.30766 ? 26  GLU A CB    1 ? 
ATOM   222  C  CG    . GLU A 1 30  ? 15.47128 25.00653  -34.79777 1.000 31.25233 ? 26  GLU A CG    1 ? 
ATOM   223  C  CD    . GLU A 1 30  ? 16.47067 25.56774  -35.78424 1.000 42.27555 ? 26  GLU A CD    1 ? 
ATOM   224  O  OE1   . GLU A 1 30  ? 16.23880 25.43837  -37.01248 1.000 42.99928 ? 26  GLU A OE1   1 ? 
ATOM   225  O  OE2   . GLU A 1 30  ? 17.48580 26.14192  -35.32603 1.000 45.21749 ? 26  GLU A OE2   1 ? 
ATOM   226  N  N     . PRO A 1 31  ? 10.67518 24.66334  -35.12019 1.000 27.90884 ? 27  PRO A N     1 ? 
ATOM   227  C  CA    . PRO A 1 31  ? 9.33262  25.26396  -35.21183 1.000 27.41585 ? 27  PRO A CA    1 ? 
ATOM   228  C  C     . PRO A 1 31  ? 8.65622  25.49635  -33.87156 1.000 29.66200 ? 27  PRO A C     1 ? 
ATOM   229  O  O     . PRO A 1 31  ? 7.68279  26.26288  -33.80905 1.000 27.70992 ? 27  PRO A O     1 ? 
ATOM   230  C  CB    . PRO A 1 31  ? 8.55324  24.24922  -36.05715 1.000 30.60044 ? 27  PRO A CB    1 ? 
ATOM   231  C  CG    . PRO A 1 31  ? 9.59553  23.63296  -36.92064 1.000 29.99729 ? 27  PRO A CG    1 ? 
ATOM   232  C  CD    . PRO A 1 31  ? 10.81407 23.52610  -36.04790 1.000 29.26540 ? 27  PRO A CD    1 ? 
ATOM   233  N  N     . TYR A 1 32  ? 9.12520  24.87180  -32.79290 1.000 24.10798 ? 28  TYR A N     1 ? 
ATOM   234  C  CA    . TYR A 1 32  ? 8.55131  25.13650  -31.47833 1.000 27.75093 ? 28  TYR A CA    1 ? 
ATOM   235  C  C     . TYR A 1 32  ? 9.25580  26.25721  -30.72258 1.000 28.32597 ? 28  TYR A C     1 ? 
ATOM   236  O  O     . TYR A 1 32  ? 8.74128  26.70722  -29.68922 1.000 33.08642 ? 28  TYR A O     1 ? 
ATOM   237  C  CB    . TYR A 1 32  ? 8.56652  23.85538  -30.63735 1.000 26.96993 ? 28  TYR A CB    1 ? 
ATOM   238  C  CG    . TYR A 1 32  ? 7.71544  22.79421  -31.24245 1.000 27.92988 ? 28  TYR A CG    1 ? 
ATOM   239  C  CD1   . TYR A 1 32  ? 6.36460  22.72211  -30.94185 1.000 33.32230 ? 28  TYR A CD1   1 ? 
ATOM   240  C  CD2   . TYR A 1 32  ? 8.24129  21.86656  -32.14216 1.000 29.00493 ? 28  TYR A CD2   1 ? 
ATOM   241  C  CE1   . TYR A 1 32  ? 5.55820  21.75229  -31.50130 1.000 32.35660 ? 28  TYR A CE1   1 ? 
ATOM   242  C  CE2   . TYR A 1 32  ? 7.42115  20.89082  -32.72189 1.000 29.46509 ? 28  TYR A CE2   1 ? 
ATOM   243  C  CZ    . TYR A 1 32  ? 6.08526  20.84469  -32.38986 1.000 31.27793 ? 28  TYR A CZ    1 ? 
ATOM   244  O  OH    . TYR A 1 32  ? 5.24502  19.88874  -32.93652 1.000 36.36144 ? 28  TYR A OH    1 ? 
ATOM   245  N  N     . GLY A 1 33  ? 10.39579 26.72023  -31.20261 1.000 27.08367 ? 29  GLY A N     1 ? 
ATOM   246  C  CA    . GLY A 1 33  ? 11.12766 27.77132  -30.51677 1.000 29.35969 ? 29  GLY A CA    1 ? 
ATOM   247  C  C     . GLY A 1 33  ? 12.60665 27.69098  -30.81913 1.000 32.29342 ? 29  GLY A C     1 ? 
ATOM   248  O  O     . GLY A 1 33  ? 13.11137 26.70469  -31.34775 1.000 31.20970 ? 29  GLY A O     1 ? 
ATOM   249  N  N     . ALA A 1 34  ? 13.30906 28.77052  -30.48275 1.000 26.01496 ? 30  ALA A N     1 ? 
ATOM   250  C  CA    . ALA A 1 34  ? 14.73977 28.80645  -30.73712 1.000 30.15581 ? 30  ALA A CA    1 ? 
ATOM   251  C  C     . ALA A 1 34  ? 15.42955 27.70886  -29.93950 1.000 29.00163 ? 30  ALA A C     1 ? 
ATOM   252  O  O     . ALA A 1 34  ? 15.12255 27.50060  -28.76258 1.000 27.60091 ? 30  ALA A O     1 ? 
ATOM   253  C  CB    . ALA A 1 34  ? 15.30717 30.17512  -30.35960 1.000 32.83102 ? 30  ALA A CB    1 ? 
ATOM   254  N  N     . VAL A 1 35  ? 16.36281 27.00736  -30.58884 1.000 30.40860 ? 31  VAL A N     1 ? 
ATOM   255  C  CA    . VAL A 1 35  ? 17.06967 25.87019  -30.00083 1.000 28.50216 ? 31  VAL A CA    1 ? 
ATOM   256  C  C     . VAL A 1 35  ? 18.49878 26.27113  -29.67203 1.000 29.17317 ? 31  VAL A C     1 ? 
ATOM   257  O  O     . VAL A 1 35  ? 19.24971 26.70435  -30.55290 1.000 31.08286 ? 31  VAL A O     1 ? 
ATOM   258  C  CB    . VAL A 1 35  ? 17.06797 24.65387  -30.94142 1.000 29.46739 ? 31  VAL A CB    1 ? 
ATOM   259  C  CG1   . VAL A 1 35  ? 17.94464 23.52488  -30.35951 1.000 27.67608 ? 31  VAL A CG1   1 ? 
ATOM   260  C  CG2   . VAL A 1 35  ? 15.64569 24.18149  -31.19325 1.000 26.23359 ? 31  VAL A CG2   1 ? 
ATOM   261  N  N     . TYR A 1 36  ? 18.88894 26.06725  -28.41717 1.000 29.04758 ? 32  TYR A N     1 ? 
ATOM   262  C  CA    . TYR A 1 36  ? 20.25780 26.35080  -28.00133 1.000 28.98016 ? 32  TYR A CA    1 ? 
ATOM   263  C  C     . TYR A 1 36  ? 21.21251 25.20856  -28.35296 1.000 28.77070 ? 32  TYR A C     1 ? 
ATOM   264  O  O     . TYR A 1 36  ? 22.27169 25.43947  -28.94548 1.000 30.10263 ? 32  TYR A O     1 ? 
ATOM   265  C  CB    . TYR A 1 36  ? 20.27378 26.64164  -26.49900 1.000 31.65960 ? 32  TYR A CB    1 ? 
ATOM   266  C  CG    . TYR A 1 36  ? 21.66195 26.78451  -25.93202 1.000 34.16782 ? 32  TYR A CG    1 ? 
ATOM   267  C  CD1   . TYR A 1 36  ? 22.48230 27.83603  -26.31529 1.000 39.74518 ? 32  TYR A CD1   1 ? 
ATOM   268  C  CD2   . TYR A 1 36  ? 22.15361 25.86448  -25.02061 1.000 37.78167 ? 32  TYR A CD2   1 ? 
ATOM   269  C  CE1   . TYR A 1 36  ? 23.76010 27.96944  -25.80560 1.000 41.89232 ? 32  TYR A CE1   1 ? 
ATOM   270  C  CE2   . TYR A 1 36  ? 23.42811 25.98753  -24.50319 1.000 43.05798 ? 32  TYR A CE2   1 ? 
ATOM   271  C  CZ    . TYR A 1 36  ? 24.22381 27.04777  -24.89808 1.000 40.75871 ? 32  TYR A CZ    1 ? 
ATOM   272  O  OH    . TYR A 1 36  ? 25.49300 27.17537  -24.38539 1.000 50.30550 ? 32  TYR A OH    1 ? 
ATOM   273  N  N     . GLN A 1 37  ? 20.84365 23.96140  -28.04087 1.000 27.01796 ? 33  GLN A N     1 ? 
ATOM   274  C  CA    . GLN A 1 37  ? 21.75762 22.84434  -28.22556 1.000 26.39367 ? 33  GLN A CA    1 ? 
ATOM   275  C  C     . GLN A 1 37  ? 20.96773 21.56483  -28.46621 1.000 26.43496 ? 33  GLN A C     1 ? 
ATOM   276  O  O     . GLN A 1 37  ? 19.92782 21.34798  -27.84955 1.000 26.14282 ? 33  GLN A O     1 ? 
ATOM   277  C  CB    . GLN A 1 37  ? 22.65013 22.69118  -26.98885 1.000 33.27927 ? 33  GLN A CB    1 ? 
ATOM   278  C  CG    . GLN A 1 37  ? 23.97715 21.99046  -27.18834 1.000 42.35549 ? 33  GLN A CG    1 ? 
ATOM   279  C  CD    . GLN A 1 37  ? 24.90790 22.19191  -25.98623 1.000 49.29998 ? 33  GLN A CD    1 ? 
ATOM   280  O  OE1   . GLN A 1 37  ? 25.09070 23.31879  -25.51052 1.000 52.14526 ? 33  GLN A OE1   1 ? 
ATOM   281  N  NE2   . GLN A 1 37  ? 25.48435 21.09860  -25.48623 1.000 52.72213 ? 33  GLN A NE2   1 ? 
ATOM   282  N  N     . ILE A 1 38  ? 21.45700 20.73726  -29.37730 1.000 23.65004 ? 34  ILE A N     1 ? 
ATOM   283  C  CA    . ILE A 1 38  ? 20.90475 19.40561  -29.60164 1.000 24.39567 ? 34  ILE A CA    1 ? 
ATOM   284  C  C     . ILE A 1 38  ? 22.06527 18.43659  -29.58571 1.000 26.61388 ? 34  ILE A C     1 ? 
ATOM   285  O  O     . ILE A 1 38  ? 23.07639 18.67287  -30.25227 1.000 29.26332 ? 34  ILE A O     1 ? 
ATOM   286  C  CB    . ILE A 1 38  ? 20.16241 19.28343  -30.94030 1.000 26.13162 ? 34  ILE A CB    1 ? 
ATOM   287  C  CG1   . ILE A 1 38  ? 18.93118 20.18016  -30.96597 1.000 28.36168 ? 34  ILE A CG1   1 ? 
ATOM   288  C  CG2   . ILE A 1 38  ? 19.74525 17.81061  -31.17245 1.000 26.38839 ? 34  ILE A CG2   1 ? 
ATOM   289  C  CD1   . ILE A 1 38  ? 18.33728 20.33689  -32.37182 1.000 32.72298 ? 34  ILE A CD1   1 ? 
ATOM   290  N  N     . ASN A 1 39  ? 21.91682 17.33657  -28.86113 1.000 27.24897 ? 35  ASN A N     1 ? 
ATOM   291  C  CA    . ASN A 1 39  ? 22.97809 16.33915  -28.80582 1.000 27.38140 ? 35  ASN A CA    1 ? 
ATOM   292  C  C     . ASN A 1 39  ? 22.35062 14.95369  -28.81597 1.000 26.04472 ? 35  ASN A C     1 ? 
ATOM   293  O  O     . ASN A 1 39  ? 21.59080 14.61727  -27.90813 1.000 23.87255 ? 35  ASN A O     1 ? 
ATOM   294  C  CB    . ASN A 1 39  ? 23.84662 16.53150  -27.56337 1.000 29.17206 ? 35  ASN A CB    1 ? 
ATOM   295  C  CG    . ASN A 1 39  ? 24.69716 17.79398  -27.63753 1.000 35.00328 ? 35  ASN A CG    1 ? 
ATOM   296  O  OD1   . ASN A 1 39  ? 24.56458 18.68748  -26.80769 1.000 40.76892 ? 35  ASN A OD1   1 ? 
ATOM   297  N  ND2   . ASN A 1 39  ? 25.56593 17.87172  -28.64568 1.000 37.48775 ? 35  ASN A ND2   1 ? 
ATOM   298  N  N     . VAL A 1 40  ? 22.65808 14.17055  -29.85054 1.000 25.12237 ? 36  VAL A N     1 ? 
ATOM   299  C  CA    . VAL A 1 40  ? 22.25352 12.76747  -29.90617 1.000 20.57971 ? 36  VAL A CA    1 ? 
ATOM   300  C  C     . VAL A 1 40  ? 23.07829 11.95817  -28.91341 1.000 23.95943 ? 36  VAL A C     1 ? 
ATOM   301  O  O     . VAL A 1 40  ? 24.29778 12.14851  -28.79050 1.000 25.69213 ? 36  VAL A O     1 ? 
ATOM   302  C  CB    . VAL A 1 40  ? 22.44203 12.25054  -31.34371 1.000 25.98879 ? 36  VAL A CB    1 ? 
ATOM   303  C  CG1   . VAL A 1 40  ? 22.30096 10.73168  -31.42051 1.000 26.03151 ? 36  VAL A CG1   1 ? 
ATOM   304  C  CG2   . VAL A 1 40  ? 21.47077 12.96213  -32.30346 1.000 28.72233 ? 36  VAL A CG2   1 ? 
ATOM   305  N  N     . LEU A 1 41  ? 22.42138 11.04926  -28.18520 1.000 25.37021 ? 37  LEU A N     1 ? 
ATOM   306  C  CA    . LEU A 1 41  ? 23.14782 10.12783  -27.31832 1.000 22.00407 ? 37  LEU A CA    1 ? 
ATOM   307  C  C     . LEU A 1 41  ? 23.71458 9.01118   -28.17282 1.000 22.14851 ? 37  LEU A C     1 ? 
ATOM   308  O  O     . LEU A 1 41  ? 22.97964 8.39126   -28.94445 1.000 22.22081 ? 37  LEU A O     1 ? 
ATOM   309  C  CB    . LEU A 1 41  ? 22.22941 9.54885   -26.23700 1.000 21.60137 ? 37  LEU A CB    1 ? 
ATOM   310  C  CG    . LEU A 1 41  ? 21.81979 10.46954  -25.08175 1.000 25.19494 ? 37  LEU A CG    1 ? 
ATOM   311  C  CD1   . LEU A 1 41  ? 20.78301 11.46602  -25.51191 1.000 26.64519 ? 37  LEU A CD1   1 ? 
ATOM   312  C  CD2   . LEU A 1 41  ? 21.26942 9.64161   -23.91125 1.000 26.01434 ? 37  LEU A CD2   1 ? 
ATOM   313  N  N     . ARG A 1 42  ? 25.02412 8.76811   -28.06364 1.000 23.08938 ? 38  ARG A N     1 ? 
ATOM   314  C  CA    . ARG A 1 42  ? 25.68984 7.82074   -28.94767 1.000 23.41015 ? 38  ARG A CA    1 ? 
ATOM   315  C  C     . ARG A 1 42  ? 26.28438 6.65226   -28.17254 1.000 28.01347 ? 38  ARG A C     1 ? 
ATOM   316  O  O     . ARG A 1 42  ? 26.58829 6.73709   -26.97858 1.000 25.22109 ? 38  ARG A O     1 ? 
ATOM   317  C  CB    . ARG A 1 42  ? 26.77943 8.50717   -29.79858 1.000 24.88053 ? 38  ARG A CB    1 ? 
ATOM   318  C  CG    . ARG A 1 42  ? 26.14355 9.38344   -30.89450 1.000 25.88422 ? 38  ARG A CG    1 ? 
ATOM   319  C  CD    . ARG A 1 42  ? 27.12989 10.14553  -31.79895 1.000 27.94876 ? 38  ARG A CD    1 ? 
ATOM   320  N  NE    . ARG A 1 42  ? 26.41011 10.67122  -32.95641 1.000 29.03179 ? 38  ARG A NE    1 ? 
ATOM   321  C  CZ    . ARG A 1 42  ? 25.90107 11.89375  -33.06203 1.000 32.65611 ? 38  ARG A CZ    1 ? 
ATOM   322  N  NH1   . ARG A 1 42  ? 26.16958 12.83979  -32.17362 1.000 28.94553 ? 38  ARG A NH1   1 ? 
ATOM   323  N  NH2   . ARG A 1 42  ? 25.11425 12.18181  -34.10063 1.000 30.50224 ? 38  ARG A NH2   1 ? 
ATOM   324  N  N     . ASP A 1 43  ? 26.43094 5.55478   -28.90544 1.000 23.93504 ? 39  ASP A N     1 ? 
ATOM   325  C  CA    . ASP A 1 43  ? 26.95821 4.28313   -28.43273 1.000 26.59417 ? 39  ASP A CA    1 ? 
ATOM   326  C  C     . ASP A 1 43  ? 28.29645 4.06883   -29.13655 1.000 24.04846 ? 39  ASP A C     1 ? 
ATOM   327  O  O     . ASP A 1 43  ? 28.34347 3.92431   -30.36239 1.000 23.36879 ? 39  ASP A O     1 ? 
ATOM   328  C  CB    . ASP A 1 43  ? 25.92947 3.19356   -28.75520 1.000 26.31997 ? 39  ASP A CB    1 ? 
ATOM   329  C  CG    . ASP A 1 43  ? 26.43928 1.78028   -28.54336 1.000 30.71748 ? 39  ASP A CG    1 ? 
ATOM   330  O  OD1   . ASP A 1 43  ? 27.64662 1.56138   -28.31710 1.000 29.57345 ? 39  ASP A OD1   1 ? 
ATOM   331  O  OD2   . ASP A 1 43  ? 25.58651 0.86886   -28.61692 1.000 31.27489 ? 39  ASP A OD2   1 ? 
ATOM   332  N  N     . ARG A 1 44  ? 29.38184 4.06334   -28.37078 1.000 21.91877 ? 40  ARG A N     1 ? 
ATOM   333  C  CA    . ARG A 1 44  ? 30.71595 3.93056   -28.93987 1.000 23.59471 ? 40  ARG A CA    1 ? 
ATOM   334  C  C     . ARG A 1 44  ? 31.32622 2.57692   -28.60595 1.000 24.86851 ? 40  ARG A C     1 ? 
ATOM   335  O  O     . ARG A 1 44  ? 32.54700 2.44079   -28.56691 1.000 27.51937 ? 40  ARG A O     1 ? 
ATOM   336  C  CB    . ARG A 1 44  ? 31.62779 5.06110   -28.46506 1.000 24.94929 ? 40  ARG A CB    1 ? 
ATOM   337  C  CG    . ARG A 1 44  ? 31.20963 6.43325   -28.99987 1.000 24.09292 ? 40  ARG A CG    1 ? 
ATOM   338  C  CD    . ARG A 1 44  ? 32.10978 7.53982   -28.48482 1.000 27.45533 ? 40  ARG A CD    1 ? 
ATOM   339  N  NE    . ARG A 1 44  ? 33.47905 7.42588   -28.97845 1.000 24.26989 ? 40  ARG A NE    1 ? 
ATOM   340  C  CZ    . ARG A 1 44  ? 34.46628 8.23025   -28.60571 1.000 29.68963 ? 40  ARG A CZ    1 ? 
ATOM   341  N  NH1   . ARG A 1 44  ? 34.27930 9.17905   -27.70127 1.000 25.83035 ? 40  ARG A NH1   1 ? 
ATOM   342  N  NH2   . ARG A 1 44  ? 35.66296 8.09215   -29.16596 1.000 30.84319 ? 40  ARG A NH2   1 ? 
ATOM   343  N  N     . SER A 1 45  ? 30.48133 1.57496   -28.36595 1.000 25.29669 ? 41  SER A N     1 ? 
ATOM   344  C  CA    . SER A 1 45  ? 30.97637 0.28489   -27.89808 1.000 28.51418 ? 41  SER A CA    1 ? 
ATOM   345  C  C     . SER A 1 45  ? 31.73576 -0.45694  -28.98063 1.000 33.06309 ? 41  SER A C     1 ? 
ATOM   346  O  O     . SER A 1 45  ? 32.57587 -1.31223  -28.66923 1.000 31.81339 ? 41  SER A O     1 ? 
ATOM   347  C  CB    . SER A 1 45  ? 29.82026 -0.57587  -27.38071 1.000 29.38470 ? 41  SER A CB    1 ? 
ATOM   348  O  OG    . SER A 1 45  ? 28.85731 -0.81559  -28.39147 1.000 29.02586 ? 41  SER A OG    1 ? 
ATOM   349  N  N     . GLN A 1 46  ? 31.45900 -0.16382  -30.24490 1.000 26.17357 ? 42  GLN A N     1 ? 
ATOM   350  C  CA    . GLN A 1 46  ? 32.22772 -0.76887  -31.31842 1.000 28.59673 ? 42  GLN A CA    1 ? 
ATOM   351  C  C     . GLN A 1 46  ? 32.23832 0.18408   -32.50344 1.000 30.67628 ? 42  GLN A C     1 ? 
ATOM   352  O  O     . GLN A 1 46  ? 31.65744 1.27234   -32.46006 1.000 32.37810 ? 42  GLN A O     1 ? 
ATOM   353  C  CB    . GLN A 1 46  ? 31.66940 -2.15073  -31.68044 1.000 31.38971 ? 42  GLN A CB    1 ? 
ATOM   354  C  CG    . GLN A 1 46  ? 30.29229 -2.11892  -32.32771 1.000 32.09669 ? 42  GLN A CG    1 ? 
ATOM   355  C  CD    . GLN A 1 46  ? 29.92665 -3.47712  -32.89885 1.000 32.43408 ? 42  GLN A CD    1 ? 
ATOM   356  O  OE1   . GLN A 1 46  ? 30.05874 -4.49472  -32.22414 1.000 31.74126 ? 42  GLN A OE1   1 ? 
ATOM   357  N  NE2   . GLN A 1 46  ? 29.47247 -3.49900  -34.13802 1.000 31.61600 ? 42  GLN A NE2   1 ? 
ATOM   358  N  N     . ASN A 1 47  ? 32.94604 -0.19965  -33.53050 1.000 29.04351 ? 43  ASN A N     1 ? 
ATOM   359  C  CA    . ASN A 1 47  ? 32.99909 0.61450   -34.73583 1.000 31.76516 ? 43  ASN A CA    1 ? 
ATOM   360  C  C     . ASN A 1 47  ? 31.95942 0.12117   -35.73115 1.000 32.16460 ? 43  ASN A C     1 ? 
ATOM   361  O  O     . ASN A 1 47  ? 31.81745 -1.09910  -35.90996 1.000 32.50417 ? 43  ASN A O     1 ? 
ATOM   362  C  CB    . ASN A 1 47  ? 34.39938 0.54674   -35.34693 1.000 36.45907 ? 43  ASN A CB    1 ? 
ATOM   363  C  CG    . ASN A 1 47  ? 34.49535 1.27158   -36.67633 1.000 44.11397 ? 43  ASN A CG    1 ? 
ATOM   364  O  OD1   . ASN A 1 47  ? 34.44311 0.65183   -37.74563 1.000 49.81287 ? 43  ASN A OD1   1 ? 
ATOM   365  N  ND2   . ASN A 1 47  ? 34.64754 2.58870   -36.61819 1.000 47.07242 ? 43  ASN A ND2   1 ? 
ATOM   366  N  N     . PRO A 1 48  ? 31.17917 1.00680   -36.36016 1.000 30.57936 ? 44  PRO A N     1 ? 
ATOM   367  C  CA    . PRO A 1 48  ? 31.13202 2.46211   -36.15792 1.000 30.32807 ? 44  PRO A CA    1 ? 
ATOM   368  C  C     . PRO A 1 48  ? 30.28992 2.81716   -34.93810 1.000 29.21093 ? 44  PRO A C     1 ? 
ATOM   369  O  O     . PRO A 1 48  ? 29.47334 2.01981   -34.48666 1.000 27.43159 ? 44  PRO A O     1 ? 
ATOM   370  C  CB    . PRO A 1 48  ? 30.49676 2.96302   -37.46072 1.000 31.79340 ? 44  PRO A CB    1 ? 
ATOM   371  C  CG    . PRO A 1 48  ? 29.52070 1.84852   -37.81209 1.000 32.25012 ? 44  PRO A CG    1 ? 
ATOM   372  C  CD    . PRO A 1 48  ? 30.24125 0.57281   -37.41418 1.000 33.91907 ? 44  PRO A CD    1 ? 
ATOM   373  N  N     . PRO A 1 49  ? 30.46105 4.01094   -34.38005 1.000 24.95058 ? 45  PRO A N     1 ? 
ATOM   374  C  CA    . PRO A 1 49  ? 29.54464 4.46486   -33.33238 1.000 25.63944 ? 45  PRO A CA    1 ? 
ATOM   375  C  C     . PRO A 1 49  ? 28.16112 4.66551   -33.92756 1.000 27.82316 ? 45  PRO A C     1 ? 
ATOM   376  O  O     . PRO A 1 49  ? 27.99941 4.81942   -35.13849 1.000 24.71336 ? 45  PRO A O     1 ? 
ATOM   377  C  CB    . PRO A 1 49  ? 30.15492 5.79144   -32.86094 1.000 29.22143 ? 45  PRO A CB    1 ? 
ATOM   378  C  CG    . PRO A 1 49  ? 31.03709 6.23110   -34.00222 1.000 29.39541 ? 45  PRO A CG    1 ? 
ATOM   379  C  CD    . PRO A 1 49  ? 31.50215 5.00302   -34.70303 1.000 27.30878 ? 45  PRO A CD    1 ? 
ATOM   380  N  N     . GLN A 1 50  ? 27.14854 4.65099   -33.06501 1.000 21.10650 ? 46  GLN A N     1 ? 
ATOM   381  C  CA    . GLN A 1 50  ? 25.79555 4.81198   -33.57165 1.000 23.39400 ? 46  GLN A CA    1 ? 
ATOM   382  C  C     . GLN A 1 50  ? 24.95940 5.59867   -32.57970 1.000 25.61401 ? 46  GLN A C     1 ? 
ATOM   383  O  O     . GLN A 1 50  ? 25.26627 5.67098   -31.38780 1.000 25.64198 ? 46  GLN A O     1 ? 
ATOM   384  C  CB    . GLN A 1 50  ? 25.11209 3.46150   -33.85478 1.000 27.02352 ? 46  GLN A CB    1 ? 
ATOM   385  C  CG    . GLN A 1 50  ? 25.12760 2.51484   -32.68004 1.000 29.30293 ? 46  GLN A CG    1 ? 
ATOM   386  C  CD    . GLN A 1 50  ? 24.03021 1.45712   -32.77320 1.000 32.75569 ? 46  GLN A CD    1 ? 
ATOM   387  O  OE1   . GLN A 1 50  ? 23.50854 1.19162   -33.84933 1.000 34.05973 ? 46  GLN A OE1   1 ? 
ATOM   388  N  NE2   . GLN A 1 50  ? 23.66793 0.87016   -31.63381 1.000 33.52322 ? 46  GLN A NE2   1 ? 
ATOM   389  N  N     . SER A 1 51  ? 23.87730 6.16947   -33.10075 1.000 24.04215 ? 47  SER A N     1 ? 
ATOM   390  C  CA    . SER A 1 51  ? 22.84637 6.76230   -32.26449 1.000 23.42541 ? 47  SER A CA    1 ? 
ATOM   391  C  C     . SER A 1 51  ? 22.16485 5.70486   -31.41431 1.000 24.17682 ? 47  SER A C     1 ? 
ATOM   392  O  O     . SER A 1 51  ? 21.91271 4.58556   -31.87426 1.000 23.81163 ? 47  SER A O     1 ? 
ATOM   393  C  CB    . SER A 1 51  ? 21.80040 7.44984   -33.13584 1.000 23.73479 ? 47  SER A CB    1 ? 
ATOM   394  O  OG    . SER A 1 51  ? 20.70486 7.88063   -32.35113 1.000 24.30271 ? 47  SER A OG    1 ? 
ATOM   395  N  N     . LYS A 1 52  ? 21.86331 6.06383   -30.16670 1.000 23.17729 ? 48  LYS A N     1 ? 
ATOM   396  C  CA    . LYS A 1 52  ? 21.03508 5.22348   -29.31280 1.000 25.68595 ? 48  LYS A CA    1 ? 
ATOM   397  C  C     . LYS A 1 52  ? 19.55814 5.50342   -29.51915 1.000 26.59111 ? 48  LYS A C     1 ? 
ATOM   398  O  O     . LYS A 1 52  ? 18.72806 4.93385   -28.80992 1.000 27.05236 ? 48  LYS A O     1 ? 
ATOM   399  C  CB    . LYS A 1 52  ? 21.39580 5.41008   -27.83169 1.000 24.23533 ? 48  LYS A CB    1 ? 
ATOM   400  C  CG    . LYS A 1 52  ? 22.85231 5.02846   -27.47654 1.000 25.14180 ? 48  LYS A CG    1 ? 
ATOM   401  C  CD    . LYS A 1 52  ? 23.17083 5.30521   -26.00050 1.000 27.22361 ? 48  LYS A CD    1 ? 
ATOM   402  C  CE    . LYS A 1 52  ? 22.36392 4.41039   -25.05401 1.000 34.02957 ? 48  LYS A CE    1 ? 
ATOM   403  N  NZ    . LYS A 1 52  ? 22.99672 3.05036   -24.92373 1.000 32.78897 ? 48  LYS A NZ    1 ? 
ATOM   404  N  N     . GLY A 1 53  ? 19.21398 6.36630   -30.47193 1.000 24.15025 ? 49  GLY A N     1 ? 
ATOM   405  C  CA    . GLY A 1 53  ? 17.80786 6.58860   -30.76459 1.000 24.32710 ? 49  GLY A CA    1 ? 
ATOM   406  C  C     . GLY A 1 53  ? 17.15043 7.57247   -29.83268 1.000 23.55876 ? 49  GLY A C     1 ? 
ATOM   407  O  O     . GLY A 1 53  ? 15.92723 7.52780   -29.63654 1.000 25.48252 ? 49  GLY A O     1 ? 
ATOM   408  N  N     . CYS A 1 54  ? 17.93543 8.45043   -29.22873 1.000 22.05437 ? 50  CYS A N     1 ? 
ATOM   409  C  CA    . CYS A 1 54  ? 17.42551 9.46746   -28.33629 1.000 22.32373 ? 50  CYS A CA    1 ? 
ATOM   410  C  C     . CYS A 1 54  ? 18.37150 10.65012  -28.38262 1.000 25.74136 ? 50  CYS A C     1 ? 
ATOM   411  O  O     . CYS A 1 54  ? 19.49813 10.55613  -28.87365 1.000 22.51141 ? 50  CYS A O     1 ? 
ATOM   412  C  CB    . CYS A 1 54  ? 17.27410 8.95302   -26.91017 1.000 26.06116 ? 50  CYS A CB    1 ? 
ATOM   413  S  SG    . CYS A 1 54  ? 18.72099 8.02730   -26.37190 1.000 29.73071 ? 50  CYS A SG    1 ? 
ATOM   414  N  N     . CYS A 1 55  ? 17.88631 11.78361  -27.90140 1.000 24.57521 ? 51  CYS A N     1 ? 
ATOM   415  C  CA    . CYS A 1 55  ? 18.70032 12.98419  -27.93772 1.000 21.97345 ? 51  CYS A CA    1 ? 
ATOM   416  C  C     . CYS A 1 55  ? 18.32090 13.85451  -26.76068 1.000 23.63910 ? 51  CYS A C     1 ? 
ATOM   417  O  O     . CYS A 1 55  ? 17.33502 13.59475  -26.07117 1.000 24.26476 ? 51  CYS A O     1 ? 
ATOM   418  C  CB    . CYS A 1 55  ? 18.53190 13.73062  -29.25537 1.000 24.34063 ? 51  CYS A CB    1 ? 
ATOM   419  S  SG    . CYS A 1 55  ? 16.95198 14.62790  -29.36929 1.000 27.28995 ? 51  CYS A SG    1 ? 
ATOM   420  N  N     . PHE A 1 56  ? 19.14882 14.87430  -26.51170 1.000 23.55188 ? 52  PHE A N     1 ? 
ATOM   421  C  CA    . PHE A 1 56  ? 18.77804 15.99085  -25.65647 1.000 22.67708 ? 52  PHE A CA    1 ? 
ATOM   422  C  C     . PHE A 1 56  ? 18.52246 17.19413  -26.54249 1.000 24.25669 ? 52  PHE A C     1 ? 
ATOM   423  O  O     . PHE A 1 56  ? 19.23779 17.39954  -27.52045 1.000 24.14114 ? 52  PHE A O     1 ? 
ATOM   424  C  CB    . PHE A 1 56  ? 19.87801 16.34604  -24.64718 1.000 24.71116 ? 52  PHE A CB    1 ? 
ATOM   425  C  CG    . PHE A 1 56  ? 20.20065 15.23277  -23.70090 1.000 25.91421 ? 52  PHE A CG    1 ? 
ATOM   426  C  CD1   . PHE A 1 56  ? 19.24450 14.78467  -22.79890 1.000 27.13561 ? 52  PHE A CD1   1 ? 
ATOM   427  C  CD2   . PHE A 1 56  ? 21.46259 14.64410  -23.70057 1.000 30.34532 ? 52  PHE A CD2   1 ? 
ATOM   428  C  CE1   . PHE A 1 56  ? 19.52696 13.75166  -21.91896 1.000 29.21445 ? 52  PHE A CE1   1 ? 
ATOM   429  C  CE2   . PHE A 1 56  ? 21.75263 13.60886  -22.82047 1.000 28.77093 ? 52  PHE A CE2   1 ? 
ATOM   430  C  CZ    . PHE A 1 56  ? 20.77591 13.16198  -21.92696 1.000 28.21827 ? 52  PHE A CZ    1 ? 
ATOM   431  N  N     . VAL A 1 57  ? 17.50818 17.98287  -26.20299 1.000 23.28859 ? 53  VAL A N     1 ? 
ATOM   432  C  CA    . VAL A 1 57  ? 17.31092 19.29457  -26.82315 1.000 22.55108 ? 53  VAL A CA    1 ? 
ATOM   433  C  C     . VAL A 1 57  ? 17.15537 20.31433  -25.70846 1.000 23.34159 ? 53  VAL A C     1 ? 
ATOM   434  O  O     . VAL A 1 57  ? 16.43980 20.06863  -24.73442 1.000 24.44164 ? 53  VAL A O     1 ? 
ATOM   435  C  CB    . VAL A 1 57  ? 16.09433 19.33102  -27.77684 1.000 23.52786 ? 53  VAL A CB    1 ? 
ATOM   436  C  CG1   . VAL A 1 57  ? 14.80861 18.93020  -27.06123 1.000 26.37872 ? 53  VAL A CG1   1 ? 
ATOM   437  C  CG2   . VAL A 1 57  ? 15.97628 20.72389  -28.43056 1.000 22.98688 ? 53  VAL A CG2   1 ? 
ATOM   438  N  N     . THR A 1 58  ? 17.85776 21.43671  -25.82909 1.000 25.63004 ? 54  THR A N     1 ? 
ATOM   439  C  CA    . THR A 1 58  ? 17.71250 22.54728  -24.89383 1.000 24.14636 ? 54  THR A CA    1 ? 
ATOM   440  C  C     . THR A 1 58  ? 17.20004 23.73899  -25.68825 1.000 24.32314 ? 54  THR A C     1 ? 
ATOM   441  O  O     . THR A 1 58  ? 17.93556 24.29565  -26.50583 1.000 26.96299 ? 54  THR A O     1 ? 
ATOM   442  C  CB    . THR A 1 58  ? 19.04402 22.87647  -24.21723 1.000 28.45847 ? 54  THR A CB    1 ? 
ATOM   443  O  OG1   . THR A 1 58  ? 19.59018 21.67958  -23.64405 1.000 29.68620 ? 54  THR A OG1   1 ? 
ATOM   444  C  CG2   . THR A 1 58  ? 18.83652 23.89376  -23.11132 1.000 32.64013 ? 54  THR A CG2   1 ? 
ATOM   445  N  N     . PHE A 1 59  ? 15.94379 24.09769  -25.47280 1.000 25.29796 ? 55  PHE A N     1 ? 
ATOM   446  C  CA    . PHE A 1 59  ? 15.41974 25.34015  -26.00651 1.000 27.88836 ? 55  PHE A CA    1 ? 
ATOM   447  C  C     . PHE A 1 59  ? 15.94422 26.51164  -25.18360 1.000 31.18791 ? 55  PHE A C     1 ? 
ATOM   448  O  O     . PHE A 1 59  ? 16.26529 26.36447  -24.00274 1.000 31.49066 ? 55  PHE A O     1 ? 
ATOM   449  C  CB    . PHE A 1 59  ? 13.89431 25.32189  -25.98307 1.000 28.75552 ? 55  PHE A CB    1 ? 
ATOM   450  C  CG    . PHE A 1 59  ? 13.28395 24.41926  -27.01732 1.000 30.30830 ? 55  PHE A CG    1 ? 
ATOM   451  C  CD1   . PHE A 1 59  ? 13.07424 24.87632  -28.31231 1.000 29.15157 ? 55  PHE A CD1   1 ? 
ATOM   452  C  CD2   . PHE A 1 59  ? 12.92816 23.11615  -26.69859 1.000 27.12037 ? 55  PHE A CD2   1 ? 
ATOM   453  C  CE1   . PHE A 1 59  ? 12.49938 24.05823  -29.27834 1.000 28.18641 ? 55  PHE A CE1   1 ? 
ATOM   454  C  CE2   . PHE A 1 59  ? 12.34747 22.28241  -27.65293 1.000 27.28557 ? 55  PHE A CE2   1 ? 
ATOM   455  C  CZ    . PHE A 1 59  ? 12.13457 22.74933  -28.95080 1.000 26.07118 ? 55  PHE A CZ    1 ? 
ATOM   456  N  N     . TYR A 1 60  ? 16.03786 27.68286  -25.82367 1.000 32.26345 ? 56  TYR A N     1 ? 
ATOM   457  C  CA    . TYR A 1 60  ? 16.44151 28.88364  -25.09226 1.000 34.35874 ? 56  TYR A CA    1 ? 
ATOM   458  C  C     . TYR A 1 60  ? 15.47984 29.19586  -23.94972 1.000 36.26354 ? 56  TYR A C     1 ? 
ATOM   459  O  O     . TYR A 1 60  ? 15.91074 29.60728  -22.86891 1.000 41.81533 ? 56  TYR A O     1 ? 
ATOM   460  C  CB    . TYR A 1 60  ? 16.55976 30.07710  -26.04260 1.000 31.11044 ? 56  TYR A CB    1 ? 
ATOM   461  C  CG    . TYR A 1 60  ? 17.86090 30.10283  -26.82386 1.000 35.28482 ? 56  TYR A CG    1 ? 
ATOM   462  C  CD1   . TYR A 1 60  ? 19.05373 30.48292  -26.21772 1.000 34.07833 ? 56  TYR A CD1   1 ? 
ATOM   463  C  CD2   . TYR A 1 60  ? 17.89563 29.74663  -28.16711 1.000 34.66159 ? 56  TYR A CD2   1 ? 
ATOM   464  C  CE1   . TYR A 1 60  ? 20.24667 30.50003  -26.93632 1.000 36.09688 ? 56  TYR A CE1   1 ? 
ATOM   465  C  CE2   . TYR A 1 60  ? 19.07453 29.76737  -28.89326 1.000 33.32173 ? 56  TYR A CE2   1 ? 
ATOM   466  C  CZ    . TYR A 1 60  ? 20.24798 30.14777  -28.27148 1.000 34.73763 ? 56  TYR A CZ    1 ? 
ATOM   467  O  OH    . TYR A 1 60  ? 21.42366 30.16680  -28.98891 1.000 39.19022 ? 56  TYR A OH    1 ? 
ATOM   468  N  N     . THR A 1 61  ? 14.18153 29.00239  -24.15134 1.000 36.91604 ? 57  THR A N     1 ? 
ATOM   469  C  CA    . THR A 1 61  ? 13.20506 29.36406  -23.13084 1.000 39.45298 ? 57  THR A CA    1 ? 
ATOM   470  C  C     . THR A 1 61  ? 12.56738 28.13207  -22.50609 1.000 37.21101 ? 57  THR A C     1 ? 
ATOM   471  O  O     . THR A 1 61  ? 12.41785 27.09104  -23.15082 1.000 37.48245 ? 57  THR A O     1 ? 
ATOM   472  C  CB    . THR A 1 61  ? 12.09127 30.26696  -23.69294 1.000 40.57959 ? 57  THR A CB    1 ? 
ATOM   473  O  OG1   . THR A 1 61  ? 11.11630 29.46840  -24.37934 1.000 37.08617 ? 57  THR A OG1   1 ? 
ATOM   474  C  CG2   . THR A 1 61  ? 12.65700 31.31053  -24.63506 1.000 37.73465 ? 57  THR A CG2   1 ? 
ATOM   475  N  N     . ARG A 1 62  ? 12.17029 28.27066  -21.23663 1.000 39.26978 ? 58  ARG A N     1 ? 
ATOM   476  C  CA    . ARG A 1 62  ? 11.39528 27.21977  -20.59031 1.000 38.85198 ? 58  ARG A CA    1 ? 
ATOM   477  C  C     . ARG A 1 62  ? 10.04213 27.04962  -21.26506 1.000 39.07588 ? 58  ARG A C     1 ? 
ATOM   478  O  O     . ARG A 1 62  ? 9.54599  25.92673  -21.39564 1.000 39.04019 ? 58  ARG A O     1 ? 
ATOM   479  C  CB    . ARG A 1 62  ? 11.21947 27.51705  -19.09725 1.000 43.47373 ? 58  ARG A CB    1 ? 
ATOM   480  C  CG    . ARG A 1 62  ? 10.27612 26.54017  -18.36538 1.000 45.86988 ? 58  ARG A CG    1 ? 
ATOM   481  C  CD    . ARG A 1 62  ? 10.31834 26.72422  -16.84310 1.000 45.56249 ? 58  ARG A CD    1 ? 
ATOM   482  N  NE    . ARG A 1 62  ? 11.57899 26.24945  -16.27718 1.000 54.15450 ? 58  ARG A NE    1 ? 
ATOM   483  C  CZ    . ARG A 1 62  ? 11.68107 25.32194  -15.33389 1.000 54.99520 ? 58  ARG A CZ    1 ? 
ATOM   484  N  NH1   . ARG A 1 62  ? 10.60646 24.76579  -14.79154 1.000 54.72025 ? 58  ARG A NH1   1 ? 
ATOM   485  N  NH2   . ARG A 1 62  ? 12.89112 24.95057  -14.91823 1.000 55.95961 ? 58  ARG A NH2   1 ? 
ATOM   486  N  N     . LYS A 1 63  ? 9.42851  28.15157  -21.70832 1.000 40.55350 ? 59  LYS A N     1 ? 
ATOM   487  C  CA    . LYS A 1 63  ? 8.11880  28.04764  -22.34825 1.000 41.97591 ? 59  LYS A CA    1 ? 
ATOM   488  C  C     . LYS A 1 63  ? 8.18218  27.19996  -23.61628 1.000 38.35197 ? 59  LYS A C     1 ? 
ATOM   489  O  O     . LYS A 1 63  ? 7.30322  26.36255  -23.86014 1.000 37.63903 ? 59  LYS A O     1 ? 
ATOM   490  C  CB    . LYS A 1 63  ? 7.57531  29.44558  -22.65222 1.000 46.10014 ? 59  LYS A CB    1 ? 
ATOM   491  C  CG    . LYS A 1 63  ? 6.56303  29.49405  -23.78570 1.000 48.76409 ? 59  LYS A CG    1 ? 
ATOM   492  C  CD    . LYS A 1 63  ? 6.19488  30.93272  -24.14192 1.000 54.03874 ? 59  LYS A CD    1 ? 
ATOM   493  C  CE    . LYS A 1 63  ? 4.98074  31.39857  -23.35911 1.000 56.05022 ? 59  LYS A CE    1 ? 
ATOM   494  N  NZ    . LYS A 1 63  ? 3.79339  30.52668  -23.62996 1.000 59.44300 ? 59  LYS A NZ    1 ? 
ATOM   495  N  N     . ALA A 1 64  ? 9.22406  27.39061  -24.42879 1.000 36.07568 ? 60  ALA A N     1 ? 
ATOM   496  C  CA    . ALA A 1 64  ? 9.35554  26.61168  -25.65547 1.000 36.86824 ? 60  ALA A CA    1 ? 
ATOM   497  C  C     . ALA A 1 64  ? 9.56892  25.12978  -25.35999 1.000 34.94438 ? 60  ALA A C     1 ? 
ATOM   498  O  O     . ALA A 1 64  ? 8.99395  24.26925  -26.03932 1.000 32.90031 ? 60  ALA A O     1 ? 
ATOM   499  C  CB    . ALA A 1 64  ? 10.50088 27.15198  -26.50543 1.000 34.19413 ? 60  ALA A CB    1 ? 
ATOM   500  N  N     . ALA A 1 65  ? 10.40775 24.81246  -24.36482 1.000 34.12184 ? 61  ALA A N     1 ? 
ATOM   501  C  CA    . ALA A 1 65  ? 10.58579 23.41517  -23.96813 1.000 33.66226 ? 61  ALA A CA    1 ? 
ATOM   502  C  C     . ALA A 1 65  ? 9.26368  22.77958  -23.56707 1.000 34.10224 ? 61  ALA A C     1 ? 
ATOM   503  O  O     . ALA A 1 65  ? 8.97199  21.63770  -23.94512 1.000 33.56408 ? 61  ALA A O     1 ? 
ATOM   504  C  CB    . ALA A 1 65  ? 11.58291 23.31417  -22.81238 1.000 32.15690 ? 61  ALA A CB    1 ? 
ATOM   505  N  N     . LEU A 1 66  ? 8.44717  23.49782  -22.79193 1.000 35.84121 ? 62  LEU A N     1 ? 
ATOM   506  C  CA    . LEU A 1 66  ? 7.20840  22.90240  -22.29592 1.000 34.29192 ? 62  LEU A CA    1 ? 
ATOM   507  C  C     . LEU A 1 66  ? 6.16984  22.76038  -23.40682 1.000 35.91543 ? 62  LEU A C     1 ? 
ATOM   508  O  O     . LEU A 1 66  ? 5.43349  21.76711  -23.45481 1.000 35.28082 ? 62  LEU A O     1 ? 
ATOM   509  C  CB    . LEU A 1 66  ? 6.65830  23.73841  -21.13836 1.000 38.08254 ? 62  LEU A CB    1 ? 
ATOM   510  C  CG    . LEU A 1 66  ? 7.49433  23.78747  -19.85647 1.000 42.52534 ? 62  LEU A CG    1 ? 
ATOM   511  C  CD1   . LEU A 1 66  ? 6.90454  24.79074  -18.87622 1.000 45.79364 ? 62  LEU A CD1   1 ? 
ATOM   512  C  CD2   . LEU A 1 66  ? 7.60320  22.40236  -19.21010 1.000 39.24440 ? 62  LEU A CD2   1 ? 
ATOM   513  N  N     . GLU A 1 67  ? 6.08735  23.74428  -24.30724 1.000 37.25177 ? 63  GLU A N     1 ? 
ATOM   514  C  CA    . GLU A 1 67  ? 5.15603  23.63268  -25.42952 1.000 36.95075 ? 63  GLU A CA    1 ? 
ATOM   515  C  C     . GLU A 1 67  ? 5.54264  22.48530  -26.35319 1.000 32.24356 ? 63  GLU A C     1 ? 
ATOM   516  O  O     . GLU A 1 67  ? 4.67377  21.74528  -26.83282 1.000 32.09505 ? 63  GLU A O     1 ? 
ATOM   517  C  CB    . GLU A 1 67  ? 5.10077  24.94592  -26.21174 1.000 40.40027 ? 63  GLU A CB    1 ? 
ATOM   518  C  CG    . GLU A 1 67  ? 4.48225  26.10662  -25.43549 1.000 45.65464 ? 63  GLU A CG    1 ? 
ATOM   519  C  CD    . GLU A 1 67  ? 4.48953  27.41023  -26.22440 1.000 58.20833 ? 63  GLU A CD    1 ? 
ATOM   520  O  OE1   . GLU A 1 67  ? 3.63561  28.28725  -25.94199 1.000 61.63215 ? 63  GLU A OE1   1 ? 
ATOM   521  O  OE2   . GLU A 1 67  ? 5.35210  27.55583  -27.12603 1.000 57.70400 ? 63  GLU A OE2   1 ? 
ATOM   522  N  N     . ALA A 1 68  ? 6.84390  22.33254  -26.62976 1.000 31.94498 ? 64  ALA A N     1 ? 
ATOM   523  C  CA    . ALA A 1 68  ? 7.30333  21.21937  -27.46032 1.000 29.20749 ? 64  ALA A CA    1 ? 
ATOM   524  C  C     . ALA A 1 68  ? 6.97034  19.88847  -26.80936 1.000 29.09248 ? 64  ALA A C     1 ? 
ATOM   525  O  O     . ALA A 1 68  ? 6.43473  18.98565  -27.46107 1.000 32.02302 ? 64  ALA A O     1 ? 
ATOM   526  C  CB    . ALA A 1 68  ? 8.80703  21.32311  -27.71428 1.000 26.66575 ? 64  ALA A CB    1 ? 
ATOM   527  N  N     . GLN A 1 69  ? 7.26792  19.75234  -25.51335 1.000 30.05649 ? 65  GLN A N     1 ? 
ATOM   528  C  CA    . GLN A 1 69  ? 6.92603  18.51365  -24.81492 1.000 31.82502 ? 65  GLN A CA    1 ? 
ATOM   529  C  C     . GLN A 1 69  ? 5.42962  18.23935  -24.89501 1.000 31.17765 ? 65  GLN A C     1 ? 
ATOM   530  O  O     . GLN A 1 69  ? 5.00575  17.11417  -25.18565 1.000 32.38169 ? 65  GLN A O     1 ? 
ATOM   531  C  CB    . GLN A 1 69  ? 7.37163  18.58361  -23.35590 1.000 34.48634 ? 65  GLN A CB    1 ? 
ATOM   532  C  CG    . GLN A 1 69  ? 6.97858  17.35311  -22.56340 1.000 33.12294 ? 65  GLN A CG    1 ? 
ATOM   533  C  CD    . GLN A 1 69  ? 7.15829  17.52590  -21.07357 1.000 35.68535 ? 65  GLN A CD    1 ? 
ATOM   534  O  OE1   . GLN A 1 69  ? 7.16880  18.64218  -20.55520 1.000 41.85682 ? 65  GLN A OE1   1 ? 
ATOM   535  N  NE2   . GLN A 1 69  ? 7.29856  16.41206  -20.36927 1.000 39.63676 ? 65  GLN A NE2   1 ? 
ATOM   536  N  N     . ASN A 1 70  ? 4.61528  19.27225  -24.67740 1.000 32.46512 ? 66  ASN A N     1 ? 
ATOM   537  C  CA    . ASN A 1 70  ? 3.17038  19.08870  -24.71067 1.000 35.01410 ? 66  ASN A CA    1 ? 
ATOM   538  C  C     . ASN A 1 70  ? 2.71112  18.63212  -26.09105 1.000 33.41557 ? 66  ASN A C     1 ? 
ATOM   539  O  O     . ASN A 1 70  ? 1.83875  17.76153  -26.20732 1.000 34.24219 ? 66  ASN A O     1 ? 
ATOM   540  C  CB    . ASN A 1 70  ? 2.48762  20.39452  -24.29162 1.000 35.51345 ? 66  ASN A CB    1 ? 
ATOM   541  C  CG    . ASN A 1 70  ? 1.00028  20.22990  -24.06699 1.000 44.86900 ? 66  ASN A CG    1 ? 
ATOM   542  O  OD1   . ASN A 1 70  ? 0.57553  19.52253  -23.15010 1.000 44.88685 ? 66  ASN A OD1   1 ? 
ATOM   543  N  ND2   . ASN A 1 70  ? 0.19800  20.89624  -24.89295 1.000 46.36278 ? 66  ASN A ND2   1 ? 
ATOM   544  N  N     . ALA A 1 71  ? 3.32633  19.17351  -27.15092 1.000 30.88983 ? 67  ALA A N     1 ? 
ATOM   545  C  CA    . ALA A 1 71  ? 2.89608  18.91043  -28.51758 1.000 29.41275 ? 67  ALA A CA    1 ? 
ATOM   546  C  C     . ALA A 1 71  ? 3.42742  17.59924  -29.08194 1.000 30.56788 ? 67  ALA A C     1 ? 
ATOM   547  O  O     . ALA A 1 71  ? 2.81322  17.04728  -30.00199 1.000 28.96411 ? 67  ALA A O     1 ? 
ATOM   548  C  CB    . ALA A 1 71  ? 3.33719  20.05628  -29.43216 1.000 31.29578 ? 67  ALA A CB    1 ? 
ATOM   549  N  N     . LEU A 1 72  ? 4.54240  17.08990  -28.56549 1.000 28.74032 ? 68  LEU A N     1 ? 
ATOM   550  C  CA    . LEU A 1 72  ? 5.23341  15.94589  -29.15709 1.000 28.97250 ? 68  LEU A CA    1 ? 
ATOM   551  C  C     . LEU A 1 72  ? 5.05686  14.65688  -28.37189 1.000 26.23838 ? 68  LEU A C     1 ? 
ATOM   552  O  O     . LEU A 1 72  ? 4.85834  13.59592  -28.97041 1.000 27.69359 ? 68  LEU A O     1 ? 
ATOM   553  C  CB    . LEU A 1 72  ? 6.73993  16.24634  -29.28343 1.000 26.12190 ? 68  LEU A CB    1 ? 
ATOM   554  C  CG    . LEU A 1 72  ? 7.12523  17.32354  -30.30880 1.000 27.67364 ? 68  LEU A CG    1 ? 
ATOM   555  C  CD1   . LEU A 1 72  ? 8.61000  17.68836  -30.21432 1.000 28.84619 ? 68  LEU A CD1   1 ? 
ATOM   556  C  CD2   . LEU A 1 72  ? 6.77024  16.89283  -31.71070 1.000 29.50052 ? 68  LEU A CD2   1 ? 
ATOM   557  N  N     . HIS A 1 73  ? 5.11392  14.73617  -27.04890 1.000 26.85441 ? 69  HIS A N     1 ? 
ATOM   558  C  CA    . HIS A 1 73  ? 5.15943  13.54893  -26.19824 1.000 28.46055 ? 69  HIS A CA    1 ? 
ATOM   559  C  C     . HIS A 1 73  ? 3.90618  12.69330  -26.36078 1.000 32.96827 ? 69  HIS A C     1 ? 
ATOM   560  O  O     . HIS A 1 73  ? 2.79310  13.14980  -26.07034 1.000 33.00360 ? 69  HIS A O     1 ? 
ATOM   561  C  CB    . HIS A 1 73  ? 5.31731  13.98490  -24.74842 1.000 27.56222 ? 69  HIS A CB    1 ? 
ATOM   562  C  CG    . HIS A 1 73  ? 5.30163  12.84762  -23.78010 1.000 35.07951 ? 69  HIS A CG    1 ? 
ATOM   563  N  ND1   . HIS A 1 73  ? 6.29636  11.89205  -23.74252 1.000 32.50871 ? 69  HIS A ND1   1 ? 
ATOM   564  C  CD2   . HIS A 1 73  ? 4.40785  12.50227  -22.82330 1.000 38.24255 ? 69  HIS A CD2   1 ? 
ATOM   565  C  CE1   . HIS A 1 73  ? 6.01877  11.01128  -22.79631 1.000 39.31902 ? 69  HIS A CE1   1 ? 
ATOM   566  N  NE2   . HIS A 1 73  ? 4.87649  11.35514  -22.22711 1.000 39.12681 ? 69  HIS A NE2   1 ? 
ATOM   567  N  N     . ASN A 1 74  ? 4.09235  11.44911  -26.82027 1.000 31.10718 ? 70  ASN A N     1 ? 
ATOM   568  C  CA    . ASN A 1 74  ? 3.01113  10.48624  -27.05616 1.000 34.83011 ? 70  ASN A CA    1 ? 
ATOM   569  C  C     . ASN A 1 74  ? 2.04595  10.95045  -28.13544 1.000 34.53478 ? 70  ASN A C     1 ? 
ATOM   570  O  O     . ASN A 1 74  ? 0.93851  10.42065  -28.24756 1.000 33.26173 ? 70  ASN A O     1 ? 
ATOM   571  C  CB    . ASN A 1 74  ? 2.23035  10.17406  -25.76960 1.000 34.42204 ? 70  ASN A CB    1 ? 
ATOM   572  C  CG    . ASN A 1 74  ? 3.00401  9.28179   -24.82410 1.000 42.02264 ? 70  ASN A CG    1 ? 
ATOM   573  O  OD1   . ASN A 1 74  ? 3.83801  8.48092   -25.25426 1.000 43.21277 ? 70  ASN A OD1   1 ? 
ATOM   574  N  ND2   . ASN A 1 74  ? 2.74382  9.42142   -23.52605 1.000 45.00911 ? 70  ASN A ND2   1 ? 
ATOM   575  N  N     . ILE A 1 75  ? 2.44958  11.92803  -28.93802 1.000 30.44427 ? 71  ILE A N     1 ? 
ATOM   576  C  CA    . ILE A 1 75  ? 1.60837  12.49809  -29.98189 1.000 32.77447 ? 71  ILE A CA    1 ? 
ATOM   577  C  C     . ILE A 1 75  ? 2.17147  12.20419  -31.36286 1.000 31.45121 ? 71  ILE A C     1 ? 
ATOM   578  O  O     . ILE A 1 75  ? 1.46576  11.71047  -32.23807 1.000 32.06691 ? 71  ILE A O     1 ? 
ATOM   579  C  CB    . ILE A 1 75  ? 1.43180  14.02167  -29.78137 1.000 31.85999 ? 71  ILE A CB    1 ? 
ATOM   580  C  CG1   . ILE A 1 75  ? 0.85037  14.34947  -28.39963 1.000 33.97802 ? 71  ILE A CG1   1 ? 
ATOM   581  C  CG2   . ILE A 1 75  ? 0.57751  14.61542  -30.89442 1.000 29.71302 ? 71  ILE A CG2   1 ? 
ATOM   582  C  CD1   . ILE A 1 75  ? -0.48666 13.78724  -28.14826 1.000 36.43731 ? 71  ILE A CD1   1 ? 
ATOM   583  N  N     . LYS A 1 76  ? 3.43901  12.53829  -31.58755 1.000 28.70855 ? 72  LYS A N     1 ? 
ATOM   584  C  CA    . LYS A 1 76  ? 4.01860  12.50534  -32.91845 1.000 25.31564 ? 72  LYS A CA    1 ? 
ATOM   585  C  C     . LYS A 1 76  ? 4.88498  11.26539  -33.07773 1.000 29.47792 ? 72  LYS A C     1 ? 
ATOM   586  O  O     . LYS A 1 76  ? 5.72091  10.97415  -32.21886 1.000 28.59061 ? 72  LYS A O     1 ? 
ATOM   587  C  CB    . LYS A 1 76  ? 4.84693  13.77127  -33.17697 1.000 28.96032 ? 72  LYS A CB    1 ? 
ATOM   588  C  CG    . LYS A 1 76  ? 5.44578  13.83305  -34.58850 1.000 28.61177 ? 72  LYS A CG    1 ? 
ATOM   589  C  CD    . LYS A 1 76  ? 6.35677  15.05084  -34.76195 1.000 33.90380 ? 72  LYS A CD    1 ? 
ATOM   590  C  CE    . LYS A 1 76  ? 6.42388  15.49078  -36.21331 1.000 35.45822 ? 72  LYS A CE    1 ? 
ATOM   591  N  NZ    . LYS A 1 76  ? 5.04516  15.82360  -36.68130 1.000 41.96842 ? 72  LYS A NZ    1 ? 
ATOM   592  N  N     . THR A 1 77  ? 4.68808  10.54526  -34.17589 1.000 30.31850 ? 73  THR A N     1 ? 
ATOM   593  C  CA    . THR A 1 77  ? 5.50148  9.38394   -34.51991 1.000 30.14127 ? 73  THR A CA    1 ? 
ATOM   594  C  C     . THR A 1 77  ? 6.40306  9.76681   -35.68072 1.000 33.04225 ? 73  THR A C     1 ? 
ATOM   595  O  O     . THR A 1 77  ? 5.92536  10.27084  -36.70397 1.000 31.10158 ? 73  THR A O     1 ? 
ATOM   596  C  CB    . THR A 1 77  ? 4.61839  8.18718   -34.87718 1.000 30.84402 ? 73  THR A CB    1 ? 
ATOM   597  O  OG1   . THR A 1 77  ? 3.82914  7.85069   -33.73215 1.000 27.70052 ? 73  THR A OG1   1 ? 
ATOM   598  C  CG2   . THR A 1 77  ? 5.45302  6.99358   -35.29822 1.000 31.95051 ? 73  THR A CG2   1 ? 
ATOM   599  N  N     . LEU A 1 78  ? 7.70324  9.57233   -35.50491 1.000 29.22453 ? 74  LEU A N     1 ? 
ATOM   600  C  CA    . LEU A 1 78  ? 8.65657  9.94584   -36.53171 1.000 30.07613 ? 74  LEU A CA    1 ? 
ATOM   601  C  C     . LEU A 1 78  ? 8.74170  8.84592   -37.58664 1.000 31.68825 ? 74  LEU A C     1 ? 
ATOM   602  O  O     . LEU A 1 78  ? 8.34599  7.71080   -37.33378 1.000 32.51665 ? 74  LEU A O     1 ? 
ATOM   603  C  CB    . LEU A 1 78  ? 10.01678 10.22904  -35.88567 1.000 28.54516 ? 74  LEU A CB    1 ? 
ATOM   604  C  CG    . LEU A 1 78  ? 9.95334  11.43651  -34.94383 1.000 26.56894 ? 74  LEU A CG    1 ? 
ATOM   605  C  CD1   . LEU A 1 78  ? 11.28887 11.66037  -34.23020 1.000 26.95971 ? 74  LEU A CD1   1 ? 
ATOM   606  C  CD2   . LEU A 1 78  ? 9.54468  12.70708  -35.69513 1.000 27.00548 ? 74  LEU A CD2   1 ? 
ATOM   607  N  N     . PRO A 1 79  ? 9.24257  9.15709   -38.78248 1.000 37.35935 ? 75  PRO A N     1 ? 
ATOM   608  C  CA    . PRO A 1 79  ? 9.16665  8.18509   -39.88486 1.000 39.43348 ? 75  PRO A CA    1 ? 
ATOM   609  C  C     . PRO A 1 79  ? 9.89445  6.88677   -39.55979 1.000 41.44110 ? 75  PRO A C     1 ? 
ATOM   610  O  O     . PRO A 1 79  ? 11.02129 6.88821   -39.05715 1.000 39.33192 ? 75  PRO A O     1 ? 
ATOM   611  C  CB    . PRO A 1 79  ? 9.82545  8.92214   -41.05460 1.000 41.49329 ? 75  PRO A CB    1 ? 
ATOM   612  C  CG    . PRO A 1 79  ? 9.75032  10.37739  -40.68979 1.000 41.39121 ? 75  PRO A CG    1 ? 
ATOM   613  C  CD    . PRO A 1 79  ? 9.88510  10.41474  -39.20630 1.000 38.00251 ? 75  PRO A CD    1 ? 
ATOM   614  N  N     . GLY A 1 80  ? 9.22745  5.76566   -39.83997 1.000 41.04855 ? 76  GLY A N     1 ? 
ATOM   615  C  CA    . GLY A 1 80  ? 9.77875  4.46148   -39.56028 1.000 37.11679 ? 76  GLY A CA    1 ? 
ATOM   616  C  C     . GLY A 1 80  ? 9.57445  3.97119   -38.14568 1.000 41.58203 ? 76  GLY A C     1 ? 
ATOM   617  O  O     . GLY A 1 80  ? 9.79873  2.77956   -37.87975 1.000 42.55029 ? 76  GLY A O     1 ? 
ATOM   618  N  N     . MET A 1 81  ? 9.15422  4.83489   -37.22567 1.000 33.92278 ? 77  MET A N     1 ? 
ATOM   619  C  CA    . MET A 1 81  ? 9.00218  4.40152   -35.84801 1.000 34.30130 ? 77  MET A CA    1 ? 
ATOM   620  C  C     . MET A 1 81  ? 7.64106  3.74378   -35.65827 1.000 38.47881 ? 77  MET A C     1 ? 
ATOM   621  O  O     . MET A 1 81  ? 6.67959  4.03393   -36.37790 1.000 36.59388 ? 77  MET A O     1 ? 
ATOM   622  C  CB    . MET A 1 81  ? 9.15838  5.57807   -34.87934 1.000 33.55018 ? 77  MET A CB    1 ? 
ATOM   623  C  CG    . MET A 1 81  ? 10.50597 6.28159   -34.94819 1.000 27.84301 ? 77  MET A CG    1 ? 
ATOM   624  S  SD    . MET A 1 81  ? 11.90042 5.21145   -34.43420 1.000 35.81905 ? 77  MET A SD    1 ? 
ATOM   625  C  CE    . MET A 1 81  ? 12.49268 4.77721   -36.05744 1.000 32.29724 ? 77  MET A CE    1 ? 
ATOM   626  N  N     . HIS A 1 82  ? 7.57079  2.84280   -34.68231 1.000 34.95076 ? 78  HIS A N     1 ? 
ATOM   627  C  CA    . HIS A 1 82  ? 6.32098  2.18034   -34.33231 1.000 38.48138 ? 78  HIS A CA    1 ? 
ATOM   628  C  C     . HIS A 1 82  ? 5.68352  2.76919   -33.08838 1.000 40.07849 ? 78  HIS A C     1 ? 
ATOM   629  O  O     . HIS A 1 82  ? 4.57580  2.35908   -32.72425 1.000 40.83738 ? 78  HIS A O     1 ? 
ATOM   630  C  CB    . HIS A 1 82  ? 6.54309  0.67660   -34.12386 1.000 37.13035 ? 78  HIS A CB    1 ? 
ATOM   631  C  CG    . HIS A 1 82  ? 6.91473  -0.06152  -35.37048 1.000 41.29919 ? 78  HIS A CG    1 ? 
ATOM   632  N  ND1   . HIS A 1 82  ? 6.90200  0.52691   -36.61730 1.000 43.75251 ? 78  HIS A ND1   1 ? 
ATOM   633  C  CD2   . HIS A 1 82  ? 7.30562  -1.34529  -35.56330 1.000 37.86287 ? 78  HIS A CD2   1 ? 
ATOM   634  C  CE1   . HIS A 1 82  ? 7.27563  -0.35998  -37.52397 1.000 44.49432 ? 78  HIS A CE1   1 ? 
ATOM   635  N  NE2   . HIS A 1 82  ? 7.52841  -1.50267  -36.90985 1.000 44.14245 ? 78  HIS A NE2   1 ? 
ATOM   636  N  N     . HIS A 1 83  ? 6.35298  3.70580   -32.42337 1.000 30.60829 ? 79  HIS A N     1 ? 
ATOM   637  C  CA    . HIS A 1 83  ? 5.81271  4.34737   -31.24218 1.000 27.06783 ? 79  HIS A CA    1 ? 
ATOM   638  C  C     . HIS A 1 83  ? 6.07897  5.84004   -31.33009 1.000 32.48269 ? 79  HIS A C     1 ? 
ATOM   639  O  O     . HIS A 1 83  ? 7.01775  6.26275   -32.01291 1.000 29.41015 ? 79  HIS A O     1 ? 
ATOM   640  C  CB    . HIS A 1 83  ? 6.42201  3.77590   -29.95836 1.000 35.60399 ? 79  HIS A CB    1 ? 
ATOM   641  C  CG    . HIS A 1 83  ? 6.13566  2.31613   -29.78007 1.000 43.97523 ? 79  HIS A CG    1 ? 
ATOM   642  N  ND1   . HIS A 1 83  ? 6.81144  1.33606   -30.47708 1.000 49.09311 ? 79  HIS A ND1   1 ? 
ATOM   643  C  CD2   . HIS A 1 83  ? 5.20765  1.67376   -29.03105 1.000 46.66885 ? 79  HIS A CD2   1 ? 
ATOM   644  C  CE1   . HIS A 1 83  ? 6.32809  0.15096   -30.14701 1.000 46.87246 ? 79  HIS A CE1   1 ? 
ATOM   645  N  NE2   . HIS A 1 83  ? 5.35519  0.32763   -29.27019 1.000 48.58903 ? 79  HIS A NE2   1 ? 
ATOM   646  N  N     . PRO A 1 84  ? 5.25780  6.65222   -30.68457 1.000 28.94859 ? 80  PRO A N     1 ? 
ATOM   647  C  CA    . PRO A 1 84  ? 5.45014  8.10097   -30.74921 1.000 29.95364 ? 80  PRO A CA    1 ? 
ATOM   648  C  C     . PRO A 1 84  ? 6.61288  8.56632   -29.88256 1.000 32.43522 ? 80  PRO A C     1 ? 
ATOM   649  O  O     . PRO A 1 84  ? 7.12565  7.85758   -29.01694 1.000 28.84170 ? 80  PRO A O     1 ? 
ATOM   650  C  CB    . PRO A 1 84  ? 4.11641  8.65636   -30.23364 1.000 30.78597 ? 80  PRO A CB    1 ? 
ATOM   651  C  CG    . PRO A 1 84  ? 3.55974  7.57757   -29.37834 1.000 30.90193 ? 80  PRO A CG    1 ? 
ATOM   652  C  CD    . PRO A 1 84  ? 4.00812  6.28497   -29.99886 1.000 32.15130 ? 80  PRO A CD    1 ? 
ATOM   653  N  N     . ILE A 1 85  ? 7.01921  9.80724   -30.15095 1.000 27.53712 ? 81  ILE A N     1 ? 
ATOM   654  C  CA    . ILE A 1 85  ? 8.05475  10.46780  -29.37901 1.000 27.30163 ? 81  ILE A CA    1 ? 
ATOM   655  C  C     . ILE A 1 85  ? 7.73407  10.41872  -27.89942 1.000 31.07685 ? 81  ILE A C     1 ? 
ATOM   656  O  O     . ILE A 1 85  ? 6.58733  10.62115  -27.47872 1.000 31.26422 ? 81  ILE A O     1 ? 
ATOM   657  C  CB    . ILE A 1 85  ? 8.18119  11.92916  -29.85236 1.000 25.59063 ? 81  ILE A CB    1 ? 
ATOM   658  C  CG1   . ILE A 1 85  ? 8.82600  11.99113  -31.23337 1.000 27.76223 ? 81  ILE A CG1   1 ? 
ATOM   659  C  CG2   . ILE A 1 85  ? 8.93406  12.76715  -28.82300 1.000 28.74656 ? 81  ILE A CG2   1 ? 
ATOM   660  C  CD1   . ILE A 1 85  ? 8.82131  13.40884  -31.83755 1.000 28.36041 ? 81  ILE A CD1   1 ? 
ATOM   661  N  N     . GLN A 1 86  ? 8.76631  10.16043  -27.10095 1.000 28.86076 ? 82  GLN A N     1 ? 
ATOM   662  C  CA    . GLN A 1 86  ? 8.72615  10.32565  -25.65520 1.000 29.34851 ? 82  GLN A CA    1 ? 
ATOM   663  C  C     . GLN A 1 86  ? 9.61425  11.50381  -25.29070 1.000 33.23641 ? 82  GLN A C     1 ? 
ATOM   664  O  O     . GLN A 1 86  ? 10.75776 11.58610  -25.74910 1.000 32.46697 ? 82  GLN A O     1 ? 
ATOM   665  C  CB    . GLN A 1 86  ? 9.19705  9.04834   -24.95687 1.000 33.20052 ? 82  GLN A CB    1 ? 
ATOM   666  C  CG    . GLN A 1 86  ? 8.60690  7.79165   -25.59742 1.000 36.89388 ? 82  GLN A CG    1 ? 
ATOM   667  C  CD    . GLN A 1 86  ? 7.19271  7.51391   -25.13084 1.000 48.73622 ? 82  GLN A CD    1 ? 
ATOM   668  O  OE1   . GLN A 1 86  ? 6.91904  7.52586   -23.92378 1.000 51.61474 ? 82  GLN A OE1   1 ? 
ATOM   669  N  NE2   . GLN A 1 86  ? 6.27811  7.26269   -26.08118 1.000 45.54408 ? 82  GLN A NE2   1 ? 
ATOM   670  N  N     . MET A 1 87  ? 9.09647  12.42194  -24.48647 1.000 27.44161 ? 83  MET A N     1 ? 
ATOM   671  C  CA    . MET A 1 87  ? 9.83659  13.63892  -24.19863 1.000 28.22039 ? 83  MET A CA    1 ? 
ATOM   672  C  C     . MET A 1 87  ? 9.59325  14.04617  -22.75841 1.000 34.08608 ? 83  MET A C     1 ? 
ATOM   673  O  O     . MET A 1 87  ? 8.44007  14.12971  -22.33262 1.000 31.15510 ? 83  MET A O     1 ? 
ATOM   674  C  CB    . MET A 1 87  ? 9.41801  14.75625  -25.15946 1.000 28.33854 ? 83  MET A CB    1 ? 
ATOM   675  C  CG    . MET A 1 87  ? 10.23321 16.00123  -25.04850 1.000 29.70053 ? 83  MET A CG    1 ? 
ATOM   676  S  SD    . MET A 1 87  ? 10.00966 17.07905  -26.47930 1.000 32.65592 ? 83  MET A SD    1 ? 
ATOM   677  C  CE    . MET A 1 87  ? 10.89230 18.52314  -25.93447 1.000 31.30935 ? 83  MET A CE    1 ? 
ATOM   678  N  N     . LYS A 1 88  ? 10.67151 14.29029  -22.01318 1.000 30.95559 ? 84  LYS A N     1 ? 
ATOM   679  C  CA    . LYS A 1 88  ? 10.58030 14.64088  -20.60007 1.000 32.26007 ? 84  LYS A CA    1 ? 
ATOM   680  C  C     . LYS A 1 88  ? 11.87930 15.31369  -20.18710 1.000 30.63615 ? 84  LYS A C     1 ? 
ATOM   681  O  O     . LYS A 1 88  ? 12.90894 15.12064  -20.84563 1.000 32.49360 ? 84  LYS A O     1 ? 
ATOM   682  C  CB    . LYS A 1 88  ? 10.31555 13.39627  -19.73145 1.000 34.49424 ? 84  LYS A CB    1 ? 
ATOM   683  C  CG    . LYS A 1 88  ? 11.38734 12.32402  -19.83323 1.000 39.38603 ? 84  LYS A CG    1 ? 
ATOM   684  C  CD    . LYS A 1 88  ? 11.07110 11.12277  -18.93322 1.000 45.30318 ? 84  LYS A CD    1 ? 
ATOM   685  C  CE    . LYS A 1 88  ? 11.31252 11.45386  -17.45882 1.000 44.26435 ? 84  LYS A CE    1 ? 
ATOM   686  N  NZ    . LYS A 1 88  ? 11.57377 10.21194  -16.65997 1.000 44.00229 ? 84  LYS A NZ    1 ? 
ATOM   687  N  N     . PRO A 1 89  ? 11.87194 16.09664  -19.09729 1.000 31.14234 ? 85  PRO A N     1 ? 
ATOM   688  C  CA    . PRO A 1 89  ? 13.11463 16.73335  -18.63273 1.000 33.42113 ? 85  PRO A CA    1 ? 
ATOM   689  C  C     . PRO A 1 89  ? 14.20687 15.70866  -18.35315 1.000 32.15055 ? 85  PRO A C     1 ? 
ATOM   690  O  O     . PRO A 1 89  ? 13.95520 14.63392  -17.80624 1.000 30.77643 ? 85  PRO A O     1 ? 
ATOM   691  C  CB    . PRO A 1 89  ? 12.68820 17.46780  -17.35588 1.000 33.42702 ? 85  PRO A CB    1 ? 
ATOM   692  C  CG    . PRO A 1 89  ? 11.21326 17.73003  -17.56512 1.000 30.98002 ? 85  PRO A CG    1 ? 
ATOM   693  C  CD    . PRO A 1 89  ? 10.70495 16.50478  -18.27783 1.000 31.94767 ? 85  PRO A CD    1 ? 
ATOM   694  N  N     . ALA A 1 90  ? 15.42194 16.05171  -18.76217 1.000 29.57147 ? 86  ALA A N     1 ? 
ATOM   695  C  CA    . ALA A 1 90  ? 16.54628 15.13324  -18.67306 1.000 29.41836 ? 86  ALA A CA    1 ? 
ATOM   696  C  C     . ALA A 1 90  ? 16.91106 14.86428  -17.21885 1.000 32.80951 ? 86  ALA A C     1 ? 
ATOM   697  O  O     . ALA A 1 90  ? 16.74194 15.71695  -16.34501 1.000 31.58985 ? 86  ALA A O     1 ? 
ATOM   698  C  CB    . ALA A 1 90  ? 17.75532 15.70176  -19.41131 1.000 28.67159 ? 86  ALA A CB    1 ? 
ATOM   699  N  N     . ASP A 1 91  ? 17.42059 13.65435  -16.96236 1.000 30.52960 ? 87  ASP A N     1 ? 
ATOM   700  C  CA    . ASP A 1 91  ? 17.78975 13.30033  -15.59761 1.000 32.13456 ? 87  ASP A CA    1 ? 
ATOM   701  C  C     . ASP A 1 91  ? 18.84191 14.23912  -15.03090 1.000 31.25510 ? 87  ASP A C     1 ? 
ATOM   702  O  O     . ASP A 1 91  ? 18.87407 14.46194  -13.81885 1.000 33.60594 ? 87  ASP A O     1 ? 
ATOM   703  C  CB    . ASP A 1 91  ? 18.30668 11.86703  -15.53083 1.000 30.09132 ? 87  ASP A CB    1 ? 
ATOM   704  C  CG    . ASP A 1 91  ? 17.22625 10.85356  -15.76859 1.000 32.60205 ? 87  ASP A CG    1 ? 
ATOM   705  O  OD1   . ASP A 1 91  ? 16.05987 11.10718  -15.39337 1.000 31.32815 ? 87  ASP A OD1   1 ? 
ATOM   706  O  OD2   . ASP A 1 91  ? 17.54322 9.78055   -16.32451 1.000 38.47851 ? 87  ASP A OD2   1 ? 
ATOM   707  N  N     . SER A 1 92  ? 19.72446 14.78022  -15.87509 1.000 28.29641 ? 88  SER A N     1 ? 
ATOM   708  C  CA    . SER A 1 92  ? 20.74369 15.68230  -15.36525 1.000 28.21758 ? 88  SER A CA    1 ? 
ATOM   709  C  C     . SER A 1 92  ? 20.14275 16.93744  -14.74398 1.000 35.88298 ? 88  SER A C     1 ? 
ATOM   710  O  O     . SER A 1 92  ? 20.86285 17.66813  -14.05070 1.000 36.21165 ? 88  SER A O     1 ? 
ATOM   711  C  CB    . SER A 1 92  ? 21.72495 16.06104  -16.48508 1.000 31.31671 ? 88  SER A CB    1 ? 
ATOM   712  O  OG    . SER A 1 92  ? 21.07549 16.76223  -17.53195 1.000 33.98841 ? 88  SER A OG    1 ? 
ATOM   713  N  N     . GLU A 1 93  ? 18.85226 17.19119  -14.96787 1.000 36.93038 ? 89  GLU A N     1 ? 
ATOM   714  C  CA    . GLU A 1 93  ? 18.14552 18.35324  -14.44385 1.000 38.96273 ? 89  GLU A CA    1 ? 
ATOM   715  C  C     . GLU A 1 93  ? 17.57168 18.13383  -13.05030 1.000 44.24489 ? 89  GLU A C     1 ? 
ATOM   716  O  O     . GLU A 1 93  ? 17.10431 19.09995  -12.43843 1.000 41.59908 ? 89  GLU A O     1 ? 
ATOM   717  C  CB    . GLU A 1 93  ? 17.00396 18.74567  -15.38469 1.000 39.33030 ? 89  GLU A CB    1 ? 
ATOM   718  C  CG    . GLU A 1 93  ? 17.44272 19.03955  -16.81165 1.000 38.81129 ? 89  GLU A CG    1 ? 
ATOM   719  C  CD    . GLU A 1 93  ? 18.22242 20.33965  -16.94528 1.000 46.62102 ? 89  GLU A CD    1 ? 
ATOM   720  O  OE1   . GLU A 1 93  ? 17.61741 21.37201  -17.31278 1.000 47.72398 ? 89  GLU A OE1   1 ? 
ATOM   721  O  OE2   . GLU A 1 93  ? 19.44787 20.32598  -16.68739 1.000 52.04148 ? 89  GLU A OE2   1 ? 
ATOM   722  N  N     . LYS A 1 94  ? 17.58269 16.89943  -12.54228 1.000 43.16324 ? 90  LYS A N     1 ? 
ATOM   723  C  CA    . LYS A 1 94  ? 17.08528 16.62511  -11.19738 1.000 44.01220 ? 90  LYS A CA    1 ? 
ATOM   724  C  C     . LYS A 1 94  ? 18.00360 17.24419  -10.15125 1.000 45.95444 ? 90  LYS A C     1 ? 
ATOM   725  O  O     . LYS A 1 94  ? 19.23053 17.20735  -10.27556 1.000 48.07351 ? 90  LYS A O     1 ? 
ATOM   726  C  CB    . LYS A 1 94  ? 16.98531 15.12106  -10.96503 1.000 43.15378 ? 90  LYS A CB    1 ? 
ATOM   727  C  CG    . LYS A 1 94  ? 16.27891 14.37892  -12.07966 1.000 47.96094 ? 90  LYS A CG    1 ? 
ATOM   728  C  CD    . LYS A 1 94  ? 14.93758 15.01759  -12.40478 1.000 49.84667 ? 90  LYS A CD    1 ? 
ATOM   729  C  CE    . LYS A 1 94  ? 14.47232 14.64916  -13.80882 1.000 46.47223 ? 90  LYS A CE    1 ? 
ATOM   730  N  NZ    . LYS A 1 94  ? 14.63072 15.78790  -14.76051 1.000 41.65097 ? 90  LYS A NZ    1 ? 
ATOM   731  N  N     . SER A 1 95  ? 17.41298 17.79758  -9.09895  1.000 48.38323 ? 91  SER A N     1 ? 
ATOM   732  C  CA    . SER A 1 95  ? 18.23941 18.53333  -8.15043  1.000 50.61789 ? 91  SER A CA    1 ? 
ATOM   733  C  C     . SER A 1 95  ? 17.89218 18.19876  -6.70796  1.000 52.54901 ? 91  SER A C     1 ? 
ATOM   734  O  O     . SER A 1 95  ? 18.77250 18.15061  -5.83923  1.000 53.71812 ? 91  SER A O     1 ? 
ATOM   735  C  CB    . SER A 1 95  ? 18.08477 20.03423  -8.39121  1.000 50.59381 ? 91  SER A CB    1 ? 
ATOM   736  O  OG    . SER A 1 95  ? 16.71167 20.39384  -8.35529  1.000 55.67831 ? 91  SER A OG    1 ? 
ATOM   737  N  N     . ASN A 1 96  ? 16.60590 17.98205  -6.45723  1.000 46.99468 ? 92  ASN A N     1 ? 
ATOM   738  C  CA    . ASN A 1 96  ? 16.07289 17.84492  -5.10969  1.000 44.18243 ? 92  ASN A CA    1 ? 
ATOM   739  C  C     . ASN A 1 96  ? 15.39935 16.48489  -4.97454  1.000 43.05198 ? 92  ASN A C     1 ? 
ATOM   740  O  O     . ASN A 1 96  ? 14.18139 16.39449  -4.77813  1.000 43.22628 ? 92  ASN A O     1 ? 
ATOM   741  C  CB    . ASN A 1 96  ? 15.09160 18.98546  -4.82916  1.000 45.48451 ? 92  ASN A CB    1 ? 
ATOM   742  C  CG    . ASN A 1 96  ? 14.60936 19.01258  -3.40113  1.000 45.97857 ? 92  ASN A CG    1 ? 
ATOM   743  O  OD1   . ASN A 1 96  ? 15.31617 18.59727  -2.48172  1.000 42.74921 ? 92  ASN A OD1   1 ? 
ATOM   744  N  ND2   . ASN A 1 96  ? 13.39311 19.50712  -3.20465  1.000 44.13086 ? 92  ASN A ND2   1 ? 
ATOM   745  N  N     . ALA A 1 97  ? 16.18352 15.41971  -5.10794  1.000 39.95253 ? 93  ALA A N     1 ? 
ATOM   746  C  CA    . ALA A 1 97  ? 15.61528 14.07845  -5.13827  1.000 43.09229 ? 93  ALA A CA    1 ? 
ATOM   747  C  C     . ALA A 1 97  ? 15.04058 13.70661  -3.77634  1.000 42.39620 ? 93  ALA A C     1 ? 
ATOM   748  O  O     . ALA A 1 97  ? 15.59515 14.06749  -2.73520  1.000 40.52262 ? 93  ALA A O     1 ? 
ATOM   749  C  CB    . ALA A 1 97  ? 16.67771 13.06482  -5.55737  1.000 42.14070 ? 93  ALA A CB    1 ? 
ATOM   750  N  N     . VAL A 1 98  ? 13.92095 12.97108  -3.79265  1.000 42.67452 ? 94  VAL A N     1 ? 
ATOM   751  C  CA    . VAL A 1 98  ? 13.27194 12.54875  -2.55029  1.000 42.10432 ? 94  VAL A CA    1 ? 
ATOM   752  C  C     . VAL A 1 98  ? 14.25938 11.83018  -1.64063  1.000 41.05513 ? 94  VAL A C     1 ? 
ATOM   753  O  O     . VAL A 1 98  ? 14.32502 12.10486  -0.43726  1.000 39.32047 ? 94  VAL A O     1 ? 
ATOM   754  C  CB    . VAL A 1 98  ? 12.04155 11.67067  -2.85772  1.000 44.28202 ? 94  VAL A CB    1 ? 
ATOM   755  C  CG1   . VAL A 1 98  ? 11.72007 10.75733  -1.68034  1.000 47.27032 ? 94  VAL A CG1   1 ? 
ATOM   756  C  CG2   . VAL A 1 98  ? 10.84075 12.54345  -3.17026  1.000 46.11584 ? 94  VAL A CG2   1 ? 
ATOM   757  N  N     . GLU A 1 99  ? 15.06970 10.92901  -2.20573  1.000 42.77900 ? 95  GLU A N     1 ? 
ATOM   758  C  CA    . GLU A 1 99  ? 15.95969 10.10797  -1.38869  1.000 44.49254 ? 95  GLU A CA    1 ? 
ATOM   759  C  C     . GLU A 1 99  ? 16.97486 10.93499  -0.61784  1.000 43.52040 ? 95  GLU A C     1 ? 
ATOM   760  O  O     . GLU A 1 99  ? 17.47743 10.47008  0.40998   1.000 44.30655 ? 95  GLU A O     1 ? 
ATOM   761  C  CB    . GLU A 1 99  ? 16.68976 9.06860   -2.24976  1.000 48.80459 ? 95  GLU A CB    1 ? 
ATOM   762  C  CG    . GLU A 1 99  ? 17.03905 9.51786   -3.66812  1.000 50.66018 ? 95  GLU A CG    1 ? 
ATOM   763  C  CD    . GLU A 1 99  ? 15.95021 9.18016   -4.68591  1.000 57.66753 ? 95  GLU A CD    1 ? 
ATOM   764  O  OE1   . GLU A 1 99  ? 14.83012 9.72938   -4.58076  1.000 58.95432 ? 95  GLU A OE1   1 ? 
ATOM   765  O  OE2   . GLU A 1 99  ? 16.21494 8.35285   -5.58831  1.000 68.72798 ? 95  GLU A OE2   1 ? 
ATOM   766  N  N     . ASP A 1 100 ? 17.27928 12.14877  -1.07281  1.000 40.41327 ? 96  ASP A N     1 ? 
ATOM   767  C  CA    . ASP A 1 100 ? 18.24014 12.99726  -0.38859  1.000 38.26073 ? 96  ASP A CA    1 ? 
ATOM   768  C  C     . ASP A 1 100 ? 17.58232 13.93425  0.60905   1.000 36.59055 ? 96  ASP A C     1 ? 
ATOM   769  O  O     . ASP A 1 100 ? 18.25629 14.81390  1.15558   1.000 35.44083 ? 96  ASP A O     1 ? 
ATOM   770  C  CB    . ASP A 1 100 ? 19.06117 13.78973  -1.41070  1.000 42.18466 ? 96  ASP A CB    1 ? 
ATOM   771  C  CG    . ASP A 1 100 ? 19.89728 12.88657  -2.30444  1.000 45.63572 ? 96  ASP A CG    1 ? 
ATOM   772  O  OD1   . ASP A 1 100 ? 20.31209 11.80883  -1.82462  1.000 47.02433 ? 96  ASP A OD1   1 ? 
ATOM   773  O  OD2   . ASP A 1 100 ? 20.13509 13.24631  -3.48130  1.000 47.66624 ? 96  ASP A OD2   1 ? 
ATOM   774  N  N     . ARG A 1 101 ? 16.27420 13.77400  0.85308   1.000 34.93183 ? 97  ARG A N     1 ? 
ATOM   775  C  CA    . ARG A 1 101 ? 15.60699 14.58445  1.86441   1.000 33.27711 ? 97  ARG A CA    1 ? 
ATOM   776  C  C     . ARG A 1 101 ? 14.66665 13.72599  2.69924   1.000 32.27521 ? 97  ARG A C     1 ? 
ATOM   777  O  O     . ARG A 1 101 ? 13.70194 14.24302  3.27092   1.000 33.10455 ? 97  ARG A O     1 ? 
ATOM   778  C  CB    . ARG A 1 101 ? 14.85687 15.76501  1.23437   1.000 36.52791 ? 97  ARG A CB    1 ? 
ATOM   779  C  CG    . ARG A 1 101 ? 13.94119 15.40199  0.06377   1.000 36.41087 ? 97  ARG A CG    1 ? 
ATOM   780  C  CD    . ARG A 1 101 ? 13.38244 16.66293  -0.61521  1.000 38.57487 ? 97  ARG A CD    1 ? 
ATOM   781  N  NE    . ARG A 1 101 ? 12.96171 16.40604  -1.98741  1.000 40.11899 ? 97  ARG A NE    1 ? 
ATOM   782  C  CZ    . ARG A 1 101 ? 11.76324 15.96176  -2.33836  1.000 42.93864 ? 97  ARG A CZ    1 ? 
ATOM   783  N  NH1   . ARG A 1 101 ? 10.82043 15.73219  -1.43926  1.000 40.32701 ? 97  ARG A NH1   1 ? 
ATOM   784  N  NH2   . ARG A 1 101 ? 11.50555 15.73790  -3.62398  1.000 44.15554 ? 97  ARG A NH2   1 ? 
ATOM   785  N  N     . LYS A 1 102 ? 14.93573 12.43329  2.77490   1.000 31.50360 ? 98  LYS A N     1 ? 
ATOM   786  C  CA    . LYS A 1 102 ? 14.14774 11.48611  3.54585   1.000 31.87216 ? 98  LYS A CA    1 ? 
ATOM   787  C  C     . LYS A 1 102 ? 14.99638 11.04862  4.72840   1.000 32.74318 ? 98  LYS A C     1 ? 
ATOM   788  O  O     . LYS A 1 102 ? 16.17059 10.71472  4.55155   1.000 31.50564 ? 98  LYS A O     1 ? 
ATOM   789  C  CB    . LYS A 1 102 ? 13.76189 10.27277  2.69428   1.000 33.82693 ? 98  LYS A CB    1 ? 
ATOM   790  C  CG    . LYS A 1 102 ? 12.93363 9.21371   3.43339   1.000 38.02818 ? 98  LYS A CG    1 ? 
ATOM   791  C  CD    . LYS A 1 102 ? 12.93438 7.88573   2.68860   1.000 44.32597 ? 98  LYS A CD    1 ? 
ATOM   792  C  CE    . LYS A 1 102 ? 11.67512 7.68769   1.86064   1.000 50.88271 ? 98  LYS A CE    1 ? 
ATOM   793  N  NZ    . LYS A 1 102 ? 11.78714 6.45157   1.03220   1.000 61.34914 ? 98  LYS A NZ    1 ? 
ATOM   794  N  N     . LEU A 1 103 ? 14.41546 11.07510  5.92358   1.000 31.85204 ? 99  LEU A N     1 ? 
ATOM   795  C  CA    . LEU A 1 103 ? 15.11964 10.71914  7.14415   1.000 26.44025 ? 99  LEU A CA    1 ? 
ATOM   796  C  C     . LEU A 1 103 ? 14.66033 9.36064   7.64191   1.000 28.93881 ? 99  LEU A C     1 ? 
ATOM   797  O  O     . LEU A 1 103 ? 13.46903 9.03514   7.58408   1.000 28.27769 ? 99  LEU A O     1 ? 
ATOM   798  C  CB    . LEU A 1 103 ? 14.88320 11.75412  8.23504   1.000 28.26456 ? 99  LEU A CB    1 ? 
ATOM   799  C  CG    . LEU A 1 103 ? 15.35608 13.16449  7.88085   1.000 27.99247 ? 99  LEU A CG    1 ? 
ATOM   800  C  CD1   . LEU A 1 103 ? 14.98140 14.12396  8.97569   1.000 30.55448 ? 99  LEU A CD1   1 ? 
ATOM   801  C  CD2   . LEU A 1 103 ? 16.86250 13.16529  7.67376   1.000 28.33950 ? 99  LEU A CD2   1 ? 
ATOM   802  N  N     . PHE A 1 104 ? 15.61167 8.58207   8.13731   1.000 26.75725 ? 100 PHE A N     1 ? 
ATOM   803  C  CA    . PHE A 1 104 ? 15.31238 7.44765   8.98787   1.000 28.77787 ? 100 PHE A CA    1 ? 
ATOM   804  C  C     . PHE A 1 104 ? 15.23455 7.96472   10.41216  1.000 29.45593 ? 100 PHE A C     1 ? 
ATOM   805  O  O     . PHE A 1 104 ? 16.15973 8.64153   10.87974  1.000 26.86304 ? 100 PHE A O     1 ? 
ATOM   806  C  CB    . PHE A 1 104 ? 16.38663 6.36788   8.86620   1.000 29.48891 ? 100 PHE A CB    1 ? 
ATOM   807  C  CG    . PHE A 1 104 ? 16.23859 5.24495   9.86142   1.000 29.85047 ? 100 PHE A CG    1 ? 
ATOM   808  C  CD1   . PHE A 1 104 ? 15.35144 4.20975   9.62995   1.000 29.14757 ? 100 PHE A CD1   1 ? 
ATOM   809  C  CD2   . PHE A 1 104 ? 16.99770 5.22760   11.02134  1.000 27.18745 ? 100 PHE A CD2   1 ? 
ATOM   810  C  CE1   . PHE A 1 104 ? 15.21521 3.16427   10.54010  1.000 31.97282 ? 100 PHE A CE1   1 ? 
ATOM   811  C  CE2   . PHE A 1 104 ? 16.87332 4.20262   11.93518  1.000 28.54328 ? 100 PHE A CE2   1 ? 
ATOM   812  C  CZ    . PHE A 1 104 ? 15.97657 3.15925   11.69352  1.000 30.73526 ? 100 PHE A CZ    1 ? 
ATOM   813  N  N     . ILE A 1 105 ? 14.11700 7.68846   11.08137  1.000 26.34547 ? 101 ILE A N     1 ? 
ATOM   814  C  CA    . ILE A 1 105 ? 13.95838 8.00389   12.49329  1.000 27.71805 ? 101 ILE A CA    1 ? 
ATOM   815  C  C     . ILE A 1 105 ? 13.98696 6.68112   13.23959  1.000 28.39562 ? 101 ILE A C     1 ? 
ATOM   816  O  O     . ILE A 1 105 ? 13.07890 5.85835   13.07496  1.000 29.33693 ? 101 ILE A O     1 ? 
ATOM   817  C  CB    . ILE A 1 105 ? 12.65472 8.75782   12.78252  1.000 27.88656 ? 101 ILE A CB    1 ? 
ATOM   818  C  CG1   . ILE A 1 105 ? 12.36150 9.79371   11.69454  1.000 28.59351 ? 101 ILE A CG1   1 ? 
ATOM   819  C  CG2   . ILE A 1 105 ? 12.76504 9.43412   14.12514  1.000 28.32797 ? 101 ILE A CG2   1 ? 
ATOM   820  C  CD1   . ILE A 1 105 ? 13.34663 10.90406  11.64110  1.000 28.97580 ? 101 ILE A CD1   1 ? 
ATOM   821  N  N     . GLY A 1 106 ? 15.03006 6.44757   14.03785  1.000 25.08085 ? 102 GLY A N     1 ? 
ATOM   822  C  CA    . GLY A 1 106 ? 15.14649 5.23448   14.81517  1.000 26.73621 ? 102 GLY A CA    1 ? 
ATOM   823  C  C     . GLY A 1 106 ? 14.89827 5.51200   16.28795  1.000 25.79073 ? 102 GLY A C     1 ? 
ATOM   824  O  O     . GLY A 1 106 ? 14.85584 6.65443   16.73080  1.000 24.35969 ? 102 GLY A O     1 ? 
ATOM   825  N  N     . MET A 1 107 ? 14.73132 4.43589   17.04828  1.000 27.39139 ? 103 MET A N     1 ? 
ATOM   826  C  CA    . MET A 1 107 ? 14.49366 4.55546   18.48334  1.000 27.25347 ? 103 MET A CA    1 ? 
ATOM   827  C  C     . MET A 1 107 ? 13.26738 5.42311   18.75878  1.000 28.51636 ? 103 MET A C     1 ? 
ATOM   828  O  O     . MET A 1 107 ? 13.29522 6.34447   19.57706  1.000 28.87555 ? 103 MET A O     1 ? 
ATOM   829  C  CB    . MET A 1 107 ? 15.72598 5.11061   19.20208  1.000 24.83242 ? 103 MET A CB    1 ? 
ATOM   830  C  CG    . MET A 1 107 ? 16.87456 4.16874   19.20520  1.000 25.86391 ? 103 MET A CG    1 ? 
ATOM   831  S  SD    . MET A 1 107 ? 16.46520 2.72857   20.21233  1.000 34.37719 ? 103 MET A SD    1 ? 
ATOM   832  C  CE    . MET A 1 107 ? 17.23772 1.50241   19.18234  1.000 31.12442 ? 103 MET A CE    1 ? 
ATOM   833  N  N     . VAL A 1 108 ? 12.18419 5.12903   18.03251  1.000 31.99460 ? 104 VAL A N     1 ? 
ATOM   834  C  CA    . VAL A 1 108 ? 10.86957 5.71872   18.25205  1.000 31.58044 ? 104 VAL A CA    1 ? 
ATOM   835  C  C     . VAL A 1 108 ? 10.06945 4.74549   19.10147  1.000 32.89931 ? 104 VAL A C     1 ? 
ATOM   836  O  O     . VAL A 1 108 ? 10.15570 3.52127   18.91108  1.000 33.69015 ? 104 VAL A O     1 ? 
ATOM   837  C  CB    . VAL A 1 108 ? 10.16009 6.00450   16.90976  1.000 34.25528 ? 104 VAL A CB    1 ? 
ATOM   838  C  CG1   . VAL A 1 108 ? 8.78768  6.57379   17.13800  1.000 37.85866 ? 104 VAL A CG1   1 ? 
ATOM   839  C  CG2   . VAL A 1 108 ? 10.98834 6.96809   16.07140  1.000 32.24615 ? 104 VAL A CG2   1 ? 
ATOM   840  N  N     . SER A 1 109 ? 9.31456  5.27400   20.05821  1.000 36.35077 ? 105 SER A N     1 ? 
ATOM   841  C  CA    . SER A 1 109 ? 8.47157  4.41197   20.87594  1.000 38.94093 ? 105 SER A CA    1 ? 
ATOM   842  C  C     . SER A 1 109 ? 7.58077  3.55461   19.98395  1.000 41.44058 ? 105 SER A C     1 ? 
ATOM   843  O  O     . SER A 1 109 ? 6.95589  4.06079   19.04882  1.000 40.08731 ? 105 SER A O     1 ? 
ATOM   844  C  CB    . SER A 1 109 ? 7.62035  5.25374   21.82734  1.000 41.59030 ? 105 SER A CB    1 ? 
ATOM   845  O  OG    . SER A 1 109 ? 6.76251  4.42038   22.59523  1.000 46.09897 ? 105 SER A OG    1 ? 
ATOM   846  N  N     . LYS A 1 110 ? 7.54810  2.24502   20.26166  1.000 38.67805 ? 106 LYS A N     1 ? 
ATOM   847  C  CA    . LYS A 1 110 ? 6.62805  1.34512   19.57147  1.000 41.72557 ? 106 LYS A CA    1 ? 
ATOM   848  C  C     . LYS A 1 110 ? 5.18328  1.81212   19.68664  1.000 43.39604 ? 106 LYS A C     1 ? 
ATOM   849  O  O     . LYS A 1 110 ? 4.32603  1.31134   18.95171  1.000 47.54990 ? 106 LYS A O     1 ? 
ATOM   850  C  CB    . LYS A 1 110 ? 6.73578  -0.08201  20.12243  1.000 41.55767 ? 106 LYS A CB    1 ? 
ATOM   851  C  CG    . LYS A 1 110 ? 8.14378  -0.63635  20.25324  1.000 47.85165 ? 106 LYS A CG    1 ? 
ATOM   852  C  CD    . LYS A 1 110 ? 8.70185  -1.13608  18.93615  1.000 44.19797 ? 106 LYS A CD    1 ? 
ATOM   853  C  CE    . LYS A 1 110 ? 10.10065 -1.73328  19.12545  1.000 44.83982 ? 106 LYS A CE    1 ? 
ATOM   854  N  NZ    . LYS A 1 110 ? 10.11753 -3.20655  18.86667  1.000 48.74706 ? 106 LYS A NZ    1 ? 
ATOM   855  N  N     . LYS A 1 111 ? 4.89665  2.76387   20.57919  1.000 41.06137 ? 107 LYS A N     1 ? 
ATOM   856  C  CA    . LYS A 1 111 ? 3.55967  3.32205   20.70513  1.000 46.93892 ? 107 LYS A CA    1 ? 
ATOM   857  C  C     . LYS A 1 111 ? 3.27999  4.44388   19.71869  1.000 48.31521 ? 107 LYS A C     1 ? 
ATOM   858  O  O     . LYS A 1 111 ? 2.11131  4.79535   19.52799  1.000 45.67176 ? 107 LYS A O     1 ? 
ATOM   859  C  CB    . LYS A 1 111 ? 3.34166  3.86736   22.11526  1.000 51.94702 ? 107 LYS A CB    1 ? 
ATOM   860  C  CG    . LYS A 1 111 ? 3.06484  2.82199   23.17322  1.000 58.75621 ? 107 LYS A CG    1 ? 
ATOM   861  C  CD    . LYS A 1 111 ? 2.73541  3.48759   24.50687  1.000 60.65801 ? 107 LYS A CD    1 ? 
ATOM   862  C  CE    . LYS A 1 111 ? 2.22011  2.47033   25.50996  1.000 62.45690 ? 107 LYS A CE    1 ? 
ATOM   863  N  NZ    . LYS A 1 111 ? 2.79281  1.12211   25.23316  1.000 61.21487 ? 107 LYS A NZ    1 ? 
ATOM   864  N  N     . CYS A 1 112 ? 4.30889  5.03898   19.11861  1.000 45.15603 ? 108 CYS A N     1 ? 
ATOM   865  C  CA    . CYS A 1 112 ? 4.08701  6.21916   18.29525  1.000 44.04809 ? 108 CYS A CA    1 ? 
ATOM   866  C  C     . CYS A 1 112 ? 3.35344  5.86331   17.00973  1.000 41.43424 ? 108 CYS A C     1 ? 
ATOM   867  O  O     . CYS A 1 112 ? 3.51070  4.77188   16.44792  1.000 44.26472 ? 108 CYS A O     1 ? 
ATOM   868  C  CB    . CYS A 1 112 ? 5.40771  6.90122   17.94250  1.000 46.66825 ? 108 CYS A CB    1 ? 
ATOM   869  S  SG    . CYS A 1 112 ? 6.25836  7.65600   19.32957  1.000 54.87419 ? 108 CYS A SG    1 ? 
ATOM   870  N  N     . ASN A 1 113 ? 2.55087  6.80985   16.54605  1.000 43.13897 ? 109 ASN A N     1 ? 
ATOM   871  C  CA    . ASN A 1 113 ? 1.90110  6.74810   15.24957  1.000 45.18453 ? 109 ASN A CA    1 ? 
ATOM   872  C  C     . ASN A 1 113 ? 2.39818  7.90771   14.39130  1.000 44.06814 ? 109 ASN A C     1 ? 
ATOM   873  O  O     . ASN A 1 113 ? 3.05950  8.83302   14.87655  1.000 42.21932 ? 109 ASN A O     1 ? 
ATOM   874  C  CB    . ASN A 1 113 ? 0.36487  6.78344   15.38924  1.000 47.17410 ? 109 ASN A CB    1 ? 
ATOM   875  C  CG    . ASN A 1 113 ? -0.14985 8.04949   16.09425  1.000 50.73316 ? 109 ASN A CG    1 ? 
ATOM   876  O  OD1   . ASN A 1 113 ? 0.38208  9.15056   15.92081  1.000 51.14335 ? 109 ASN A OD1   1 ? 
ATOM   877  N  ND2   . ASN A 1 113 ? -1.20251 7.88696   16.89048  1.000 52.03598 ? 109 ASN A ND2   1 ? 
ATOM   878  N  N     . GLU A 1 114 ? 2.03984  7.85302   13.10488  1.000 44.16945 ? 110 GLU A N     1 ? 
ATOM   879  C  CA    . GLU A 1 114 ? 2.48489  8.85734   12.14199  1.000 42.46011 ? 110 GLU A CA    1 ? 
ATOM   880  C  C     . GLU A 1 114 ? 2.20928  10.27598  12.62274  1.000 41.51250 ? 110 GLU A C     1 ? 
ATOM   881  O  O     . GLU A 1 114 ? 2.94206  11.20545  12.27206  1.000 44.26002 ? 110 GLU A O     1 ? 
ATOM   882  C  CB    . GLU A 1 114 ? 1.80924  8.60642   10.78715  1.000 41.71948 ? 110 GLU A CB    1 ? 
ATOM   883  C  CG    . GLU A 1 114 ? 2.39794  7.43662   9.95898   1.000 41.99427 ? 110 GLU A CG    1 ? 
ATOM   884  C  CD    . GLU A 1 114 ? 2.00969  6.03469   10.46008  1.000 48.85820 ? 110 GLU A CD    1 ? 
ATOM   885  O  OE1   . GLU A 1 114 ? 1.30715  5.91842   11.49413  1.000 50.13335 ? 110 GLU A OE1   1 ? 
ATOM   886  O  OE2   . GLU A 1 114 ? 2.40974  5.03692   9.81316   1.000 44.78748 ? 110 GLU A OE2   1 ? 
ATOM   887  N  N     . ASN A 1 115 ? 1.17590  10.46777  13.44113  1.000 44.50570 ? 111 ASN A N     1 ? 
ATOM   888  C  CA    . ASN A 1 115 ? 0.83411  11.82170  13.85330  1.000 44.23477 ? 111 ASN A CA    1 ? 
ATOM   889  C  C     . ASN A 1 115 ? 1.78956  12.35928  14.91016  1.000 43.05550 ? 111 ASN A C     1 ? 
ATOM   890  O  O     . ASN A 1 115 ? 2.12404  13.54802  14.89405  1.000 43.06785 ? 111 ASN A O     1 ? 
ATOM   891  C  CB    . ASN A 1 115 ? -0.60096 11.88214  14.37390  1.000 48.73596 ? 111 ASN A CB    1 ? 
ATOM   892  C  CG    . ASN A 1 115 ? -0.98841 13.28739  14.80404  1.000 55.49659 ? 111 ASN A CG    1 ? 
ATOM   893  O  OD1   . ASN A 1 115 ? -0.97518 13.61538  15.99539  1.000 56.33536 ? 111 ASN A OD1   1 ? 
ATOM   894  N  ND2   . ASN A 1 115 ? -1.29488 14.13920  13.82819  1.000 53.32375 ? 111 ASN A ND2   1 ? 
ATOM   895  N  N     . ASP A 1 116 ? 2.21060  11.51767  15.85469  1.000 44.97537 ? 112 ASP A N     1 ? 
ATOM   896  C  CA    . ASP A 1 116 ? 3.20186  11.95960  16.83069  1.000 43.34869 ? 112 ASP A CA    1 ? 
ATOM   897  C  C     . ASP A 1 116 ? 4.48236  12.38881  16.13474  1.000 40.53084 ? 112 ASP A C     1 ? 
ATOM   898  O  O     . ASP A 1 116 ? 5.11118  13.38364  16.52113  1.000 38.82779 ? 112 ASP A O     1 ? 
ATOM   899  C  CB    . ASP A 1 116 ? 3.50453  10.83948  17.81899  1.000 44.28657 ? 112 ASP A CB    1 ? 
ATOM   900  C  CG    . ASP A 1 116 ? 2.27098  10.08438  18.22847  1.000 49.78938 ? 112 ASP A CG    1 ? 
ATOM   901  O  OD1   . ASP A 1 116 ? 1.33949  10.73357  18.74582  1.000 48.02889 ? 112 ASP A OD1   1 ? 
ATOM   902  O  OD2   . ASP A 1 116 ? 2.23238  8.85040   18.01144  1.000 52.90075 ? 112 ASP A OD2   1 ? 
ATOM   903  N  N     . ILE A 1 117 ? 4.87943  11.64593  15.10078  1.000 41.78319 ? 113 ILE A N     1 ? 
ATOM   904  C  CA    . ILE A 1 117 ? 6.12090  11.95830  14.40378  1.000 41.41386 ? 113 ILE A CA    1 ? 
ATOM   905  C  C     . ILE A 1 117 ? 5.99701  13.30131  13.70278  1.000 39.76917 ? 113 ILE A C     1 ? 
ATOM   906  O  O     . ILE A 1 117 ? 6.88295  14.15537  13.80778  1.000 38.66260 ? 113 ILE A O     1 ? 
ATOM   907  C  CB    . ILE A 1 117 ? 6.49002  10.82910  13.42771  1.000 40.31846 ? 113 ILE A CB    1 ? 
ATOM   908  C  CG1   . ILE A 1 117 ? 6.64636  9.50757   14.18275  1.000 41.89839 ? 113 ILE A CG1   1 ? 
ATOM   909  C  CG2   . ILE A 1 117 ? 7.81288  11.13450  12.74979  1.000 39.12953 ? 113 ILE A CG2   1 ? 
ATOM   910  C  CD1   . ILE A 1 117 ? 7.67290  9.57969   15.29717  1.000 45.03555 ? 113 ILE A CD1   1 ? 
ATOM   911  N  N     . ARG A 1 118 ? 4.87695  13.51959  13.00842  1.000 40.91433 ? 114 ARG A N     1 ? 
ATOM   912  C  CA    . ARG A 1 118 ? 4.64788  14.80470  12.35378  1.000 39.92759 ? 114 ARG A CA    1 ? 
ATOM   913  C  C     . ARG A 1 118 ? 4.73051  15.95246  13.35207  1.000 39.88977 ? 114 ARG A C     1 ? 
ATOM   914  O  O     . ARG A 1 118 ? 5.38099  16.96766  13.09250  1.000 41.49146 ? 114 ARG A O     1 ? 
ATOM   915  C  CB    . ARG A 1 118 ? 3.29444  14.80290  11.64183  1.000 43.19783 ? 114 ARG A CB    1 ? 
ATOM   916  C  CG    . ARG A 1 118 ? 3.27968  14.00352  10.35230  1.000 48.23523 ? 114 ARG A CG    1 ? 
ATOM   917  C  CD    . ARG A 1 118 ? 1.88185  13.93113  9.73726   1.000 50.95330 ? 114 ARG A CD    1 ? 
ATOM   918  N  NE    . ARG A 1 118 ? 1.88787  13.15318  8.50309   1.000 51.37499 ? 114 ARG A NE    1 ? 
ATOM   919  C  CZ    . ARG A 1 118 ? 2.15042  13.65742  7.30475   1.000 48.97890 ? 114 ARG A CZ    1 ? 
ATOM   920  N  NH1   . ARG A 1 118 ? 2.39017  14.94886  7.13649   1.000 48.87389 ? 114 ARG A NH1   1 ? 
ATOM   921  N  NH2   . ARG A 1 118 ? 2.18499  12.84418  6.25099   1.000 48.31047 ? 114 ARG A NH2   1 ? 
ATOM   922  N  N     . VAL A 1 119 ? 4.08976  15.80291  14.51243  1.000 41.99630 ? 115 VAL A N     1 ? 
ATOM   923  C  CA    . VAL A 1 119 ? 4.15554  16.84850  15.53033  1.000 40.61856 ? 115 VAL A CA    1 ? 
ATOM   924  C  C     . VAL A 1 119 ? 5.60400  17.13746  15.91296  1.000 39.53612 ? 115 VAL A C     1 ? 
ATOM   925  O  O     . VAL A 1 119 ? 5.99055  18.29745  16.09428  1.000 37.18195 ? 115 VAL A O     1 ? 
ATOM   926  C  CB    . VAL A 1 119 ? 3.30929  16.45284  16.75541  1.000 43.33141 ? 115 VAL A CB    1 ? 
ATOM   927  C  CG1   . VAL A 1 119 ? 3.56317  17.41228  17.90621  1.000 45.39482 ? 115 VAL A CG1   1 ? 
ATOM   928  C  CG2   . VAL A 1 119 ? 1.82954  16.43242  16.39097  1.000 46.04085 ? 115 VAL A CG2   1 ? 
ATOM   929  N  N     . MET A 1 120 ? 6.43277  16.08901  16.02736  1.000 40.33674 ? 116 MET A N     1 ? 
ATOM   930  C  CA    . MET A 1 120 ? 7.82507  16.28337  16.43554  1.000 38.81057 ? 116 MET A CA    1 ? 
ATOM   931  C  C     . MET A 1 120 ? 8.67397  16.91591  15.33795  1.000 37.91142 ? 116 MET A C     1 ? 
ATOM   932  O  O     . MET A 1 120 ? 9.63422  17.63163  15.64019  1.000 35.69352 ? 116 MET A O     1 ? 
ATOM   933  C  CB    . MET A 1 120 ? 8.46779  14.95282  16.83672  1.000 38.86515 ? 116 MET A CB    1 ? 
ATOM   934  C  CG    . MET A 1 120 ? 7.79084  14.21597  17.97109  1.000 41.53225 ? 116 MET A CG    1 ? 
ATOM   935  S  SD    . MET A 1 120 ? 8.52849  12.57167  18.12666  1.000 50.59426 ? 116 MET A SD    1 ? 
ATOM   936  C  CE    . MET A 1 120 ? 10.23513 13.04590  18.36772  1.000 41.70032 ? 116 MET A CE    1 ? 
ATOM   937  N  N     . PHE A 1 121 ? 8.37659  16.63532  14.06782  1.000 36.14243 ? 117 PHE A N     1 ? 
ATOM   938  C  CA    . PHE A 1 121 ? 9.25517  17.06345  12.99023  1.000 36.41132 ? 117 PHE A CA    1 ? 
ATOM   939  C  C     . PHE A 1 121 ? 8.67777  18.17655  12.13063  1.000 39.07332 ? 117 PHE A C     1 ? 
ATOM   940  O  O     . PHE A 1 121 ? 9.42875  18.77903  11.35322  1.000 39.56800 ? 117 PHE A O     1 ? 
ATOM   941  C  CB    . PHE A 1 121 ? 9.63628  15.85802  12.11529  1.000 37.29341 ? 117 PHE A CB    1 ? 
ATOM   942  C  CG    . PHE A 1 121 ? 10.61225 14.91860  12.78988  1.000 35.02406 ? 117 PHE A CG    1 ? 
ATOM   943  C  CD1   . PHE A 1 121 ? 11.98248 15.15637  12.72088  1.000 34.21398 ? 117 PHE A CD1   1 ? 
ATOM   944  C  CD2   . PHE A 1 121 ? 10.15701 13.82330  13.50888  1.000 36.81046 ? 117 PHE A CD2   1 ? 
ATOM   945  C  CE1   . PHE A 1 121 ? 12.88558 14.31729  13.35433  1.000 32.97330 ? 117 PHE A CE1   1 ? 
ATOM   946  C  CE2   . PHE A 1 121 ? 11.04530 12.97545  14.13974  1.000 33.74105 ? 117 PHE A CE2   1 ? 
ATOM   947  C  CZ    . PHE A 1 121 ? 12.41968 13.22487  14.06477  1.000 32.30807 ? 117 PHE A CZ    1 ? 
ATOM   948  N  N     . SER A 1 122 ? 7.38171  18.47173  12.26855  1.000 38.51290 ? 118 SER A N     1 ? 
ATOM   949  C  CA    . SER A 1 122 ? 6.77029  19.64753  11.64807  1.000 41.73556 ? 118 SER A CA    1 ? 
ATOM   950  C  C     . SER A 1 122 ? 7.51233  20.96019  11.84917  1.000 39.35828 ? 118 SER A C     1 ? 
ATOM   951  O  O     . SER A 1 122 ? 7.52364  21.76627  10.90765  1.000 45.08602 ? 118 SER A O     1 ? 
ATOM   952  C  CB    . SER A 1 122 ? 5.33272  19.82780  12.16380  1.000 36.78792 ? 118 SER A CB    1 ? 
ATOM   953  O  OG    . SER A 1 122 ? 4.51463  18.81309  11.64905  1.000 47.93044 ? 118 SER A OG    1 ? 
ATOM   954  N  N     . PRO A 1 123 ? 8.09109  21.27532  13.01866  1.000 40.36026 ? 119 PRO A N     1 ? 
ATOM   955  C  CA    . PRO A 1 123 ? 8.77010  22.57643  13.15554  1.000 39.84213 ? 119 PRO A CA    1 ? 
ATOM   956  C  C     . PRO A 1 123 ? 9.88105  22.81014  12.14533  1.000 42.61331 ? 119 PRO A C     1 ? 
ATOM   957  O  O     . PRO A 1 123 ? 10.33025 23.95359  12.00329  1.000 45.34032 ? 119 PRO A O     1 ? 
ATOM   958  C  CB    . PRO A 1 123 ? 9.34068  22.53449  14.58098  1.000 42.52637 ? 119 PRO A CB    1 ? 
ATOM   959  C  CG    . PRO A 1 123 ? 8.50332  21.54909  15.29955  1.000 39.85134 ? 119 PRO A CG    1 ? 
ATOM   960  C  CD    . PRO A 1 123 ? 8.07149  20.53647  14.29672  1.000 41.83918 ? 119 PRO A CD    1 ? 
ATOM   961  N  N     . PHE A 1 124 ? 10.34442 21.77906  11.44475  1.000 42.79779 ? 120 PHE A N     1 ? 
ATOM   962  C  CA    . PHE A 1 124 ? 11.52942 21.88936  10.60792  1.000 39.54218 ? 120 PHE A CA    1 ? 
ATOM   963  C  C     . PHE A 1 124 ? 11.21963 22.03464  9.12869   1.000 40.32744 ? 120 PHE A C     1 ? 
ATOM   964  O  O     . PHE A 1 124 ? 12.14847 22.22110  8.33933   1.000 42.36122 ? 120 PHE A O     1 ? 
ATOM   965  C  CB    . PHE A 1 124 ? 12.43322 20.67868  10.85155  1.000 39.06955 ? 120 PHE A CB    1 ? 
ATOM   966  C  CG    . PHE A 1 124 ? 12.80024 20.53028  12.28144  1.000 35.15970 ? 120 PHE A CG    1 ? 
ATOM   967  C  CD1   . PHE A 1 124 ? 13.68822 21.41557  12.85537  1.000 36.96644 ? 120 PHE A CD1   1 ? 
ATOM   968  C  CD2   . PHE A 1 124 ? 12.20032 19.56766  13.07152  1.000 37.59663 ? 120 PHE A CD2   1 ? 
ATOM   969  C  CE1   . PHE A 1 124 ? 14.00988 21.32432  14.18342  1.000 38.88264 ? 120 PHE A CE1   1 ? 
ATOM   970  C  CE2   . PHE A 1 124 ? 12.51771 19.46809  14.40588  1.000 38.53079 ? 120 PHE A CE2   1 ? 
ATOM   971  C  CZ    . PHE A 1 124 ? 13.42969 20.34668  14.96207  1.000 37.65415 ? 120 PHE A CZ    1 ? 
ATOM   972  N  N     . GLY A 1 125 ? 9.96127  21.95789  8.73471   1.000 40.08811 ? 121 GLY A N     1 ? 
ATOM   973  C  CA    . GLY A 1 125 ? 9.59001  22.22376  7.35914   1.000 41.26079 ? 121 GLY A CA    1 ? 
ATOM   974  C  C     . GLY A 1 125 ? 8.38064  21.40802  6.95725   1.000 44.59227 ? 121 GLY A C     1 ? 
ATOM   975  O  O     . GLY A 1 125 ? 7.79753  20.67455  7.75237   1.000 45.39663 ? 121 GLY A O     1 ? 
ATOM   976  N  N     . GLN A 1 126 ? 8.02125  21.54535  5.68564   1.000 45.77575 ? 122 GLN A N     1 ? 
ATOM   977  C  CA    . GLN A 1 126 ? 6.88120  20.81390  5.15387   1.000 46.83524 ? 122 GLN A CA    1 ? 
ATOM   978  C  C     . GLN A 1 126 ? 7.21931  19.33320  5.04427   1.000 43.89533 ? 122 GLN A C     1 ? 
ATOM   979  O  O     . GLN A 1 126 ? 8.17254  18.95526  4.35872   1.000 41.81832 ? 122 GLN A O     1 ? 
ATOM   980  C  CB    . GLN A 1 126 ? 6.47632  21.37539  3.79335   1.000 49.06824 ? 122 GLN A CB    1 ? 
ATOM   981  C  CG    . GLN A 1 126 ? 5.18056  20.78140  3.23931   1.000 54.98152 ? 122 GLN A CG    1 ? 
ATOM   982  C  CD    . GLN A 1 126 ? 4.95030  21.12645  1.77037   1.000 62.62062 ? 122 GLN A CD    1 ? 
ATOM   983  O  OE1   . GLN A 1 126 ? 5.89963  21.30344  1.00373   1.000 63.95135 ? 122 GLN A OE1   1 ? 
ATOM   984  N  NE2   . GLN A 1 126 ? 3.68396  21.22221  1.37447   1.000 65.13750 ? 122 GLN A NE2   1 ? 
ATOM   985  N  N     . ILE A 1 127 ? 6.43903  18.49832  5.72110   1.000 42.70201 ? 123 ILE A N     1 ? 
ATOM   986  C  CA    . ILE A 1 127 ? 6.54075  17.04935  5.59402   1.000 46.46575 ? 123 ILE A CA    1 ? 
ATOM   987  C  C     . ILE A 1 127 ? 5.60466  16.61071  4.47807   1.000 48.69029 ? 123 ILE A C     1 ? 
ATOM   988  O  O     . ILE A 1 127 ? 4.40386  16.90163  4.51790   1.000 49.44478 ? 123 ILE A O     1 ? 
ATOM   989  C  CB    . ILE A 1 127 ? 6.17946  16.34674  6.91263   1.000 43.85868 ? 123 ILE A CB    1 ? 
ATOM   990  C  CG1   . ILE A 1 127 ? 7.15955  16.74323  8.01919   1.000 44.17075 ? 123 ILE A CG1   1 ? 
ATOM   991  C  CG2   . ILE A 1 127 ? 6.12749  14.84043  6.71349   1.000 44.12544 ? 123 ILE A CG2   1 ? 
ATOM   992  C  CD1   . ILE A 1 127 ? 6.79359  16.16729  9.37582   1.000 44.41325 ? 123 ILE A CD1   1 ? 
ATOM   993  N  N     . GLU A 1 128 ? 6.13539  15.89581  3.48863   1.000 42.30285 ? 124 GLU A N     1 ? 
ATOM   994  C  CA    . GLU A 1 128 ? 5.27625  15.39927  2.42637   1.000 46.72469 ? 124 GLU A CA    1 ? 
ATOM   995  C  C     . GLU A 1 128 ? 4.98140  13.90490  2.53663   1.000 48.48591 ? 124 GLU A C     1 ? 
ATOM   996  O  O     . GLU A 1 128 ? 4.07633  13.41657  1.84770   1.000 49.35667 ? 124 GLU A O     1 ? 
ATOM   997  C  CB    . GLU A 1 128 ? 5.86926  15.74665  1.04962   1.000 48.35174 ? 124 GLU A CB    1 ? 
ATOM   998  C  CG    . GLU A 1 128 ? 7.13233  15.02166  0.61266   1.000 48.13270 ? 124 GLU A CG    1 ? 
ATOM   999  C  CD    . GLU A 1 128 ? 7.65042  15.56712  -0.72487  1.000 52.45972 ? 124 GLU A CD    1 ? 
ATOM   1000 O  OE1   . GLU A 1 128 ? 7.52853  16.79826  -0.94563  1.000 51.88163 ? 124 GLU A OE1   1 ? 
ATOM   1001 O  OE2   . GLU A 1 128 ? 8.15532  14.77516  -1.56151  1.000 50.72014 ? 124 GLU A OE2   1 ? 
ATOM   1002 N  N     . GLU A 1 129 ? 5.67680  13.17793  3.41080   1.000 43.58496 ? 125 GLU A N     1 ? 
ATOM   1003 C  CA    . GLU A 1 129 ? 5.33268  11.78371  3.66282   1.000 43.88161 ? 125 GLU A CA    1 ? 
ATOM   1004 C  C     . GLU A 1 129 ? 5.89220  11.37614  5.01832   1.000 44.35996 ? 125 GLU A C     1 ? 
ATOM   1005 O  O     . GLU A 1 129 ? 6.99084  11.78768  5.38686   1.000 39.41541 ? 125 GLU A O     1 ? 
ATOM   1006 C  CB    . GLU A 1 129 ? 5.86740  10.85584  2.56391   1.000 46.14557 ? 125 GLU A CB    1 ? 
ATOM   1007 C  CG    . GLU A 1 129 ? 5.39295  9.41468   2.70025   1.000 56.48938 ? 125 GLU A CG    1 ? 
ATOM   1008 C  CD    . GLU A 1 129 ? 6.27075  8.42750   1.94916   1.000 66.40037 ? 125 GLU A CD    1 ? 
ATOM   1009 O  OE1   . GLU A 1 129 ? 6.23651  8.43379   0.69928   1.000 69.48063 ? 125 GLU A OE1   1 ? 
ATOM   1010 O  OE2   . GLU A 1 129 ? 7.00355  7.65138   2.61055   1.000 71.66398 ? 125 GLU A OE2   1 ? 
ATOM   1011 N  N     . CYS A 1 130 ? 5.13347  10.56446  5.74998   1.000 41.75696 ? 126 CYS A N     1 ? 
ATOM   1012 C  CA    . CYS A 1 130 ? 5.56095  10.09071  7.06078   1.000 41.89177 ? 126 CYS A CA    1 ? 
ATOM   1013 C  C     . CYS A 1 130 ? 4.98089  8.70173   7.26589   1.000 44.26493 ? 126 CYS A C     1 ? 
ATOM   1014 O  O     . CYS A 1 130 ? 3.76442  8.52144   7.16921   1.000 44.94757 ? 126 CYS A O     1 ? 
ATOM   1015 C  CB    . CYS A 1 130 ? 5.10003  11.04435  8.15846   1.000 43.58789 ? 126 CYS A CB    1 ? 
ATOM   1016 S  SG    . CYS A 1 130 ? 5.54739  10.52157  9.82534   1.000 51.66612 ? 126 CYS A SG    1 ? 
ATOM   1017 N  N     . ARG A 1 131 ? 5.83624  7.71557   7.52120   1.000 38.69424 ? 127 ARG A N     1 ? 
ATOM   1018 C  CA    . ARG A 1 131 ? 5.36024  6.35508   7.73981   1.000 42.35081 ? 127 ARG A CA    1 ? 
ATOM   1019 C  C     . ARG A 1 131 ? 6.09348  5.72856   8.91219   1.000 40.37102 ? 127 ARG A C     1 ? 
ATOM   1020 O  O     . ARG A 1 131 ? 7.32629  5.71345   8.93160   1.000 35.78588 ? 127 ARG A O     1 ? 
ATOM   1021 C  CB    . ARG A 1 131 ? 5.56030  5.46544   6.50303   1.000 45.05564 ? 127 ARG A CB    1 ? 
ATOM   1022 C  CG    . ARG A 1 131 ? 5.63039  6.18731   5.16319   1.000 57.29416 ? 127 ARG A CG    1 ? 
ATOM   1023 C  CD    . ARG A 1 131 ? 5.48363  5.18984   4.01169   1.000 62.18043 ? 127 ARG A CD    1 ? 
ATOM   1024 N  NE    . ARG A 1 131 ? 5.97117  3.86359   4.37794   1.000 66.87900 ? 127 ARG A NE    1 ? 
ATOM   1025 C  CZ    . ARG A 1 131 ? 7.19005  3.40790   4.11877   1.000 68.53429 ? 127 ARG A CZ    1 ? 
ATOM   1026 N  NH1   . ARG A 1 131 ? 8.08188  4.14395   3.47064   1.000 67.75047 ? 127 ARG A NH1   1 ? 
ATOM   1027 N  NH2   . ARG A 1 131 ? 7.52169  2.18137   4.51680   1.000 68.12894 ? 127 ARG A NH2   1 ? 
ATOM   1028 N  N     . ILE A 1 132 ? 5.33561  5.20778   9.87596   1.000 37.70815 ? 128 ILE A N     1 ? 
ATOM   1029 C  CA    . ILE A 1 132 ? 5.88459  4.25185   10.83103  1.000 36.38376 ? 128 ILE A CA    1 ? 
ATOM   1030 C  C     . ILE A 1 132 ? 6.11903  2.93065   10.11563  1.000 36.61339 ? 128 ILE A C     1 ? 
ATOM   1031 O  O     . ILE A 1 132 ? 5.23866  2.42387   9.40877   1.000 35.76402 ? 128 ILE A O     1 ? 
ATOM   1032 C  CB    . ILE A 1 132 ? 4.92890  4.05462   12.01716  1.000 40.20818 ? 128 ILE A CB    1 ? 
ATOM   1033 C  CG1   . ILE A 1 132 ? 4.64417  5.37825   12.72224  1.000 38.51642 ? 128 ILE A CG1   1 ? 
ATOM   1034 C  CG2   . ILE A 1 132 ? 5.46058  2.96792   12.96605  1.000 37.93723 ? 128 ILE A CG2   1 ? 
ATOM   1035 C  CD1   . ILE A 1 132 ? 5.85999  6.07342   13.27011  1.000 37.82873 ? 128 ILE A CD1   1 ? 
ATOM   1036 N  N     . LEU A 1 133 ? 7.30132  2.35823   10.29700  1.000 34.14153 ? 129 LEU A N     1 ? 
ATOM   1037 C  CA    . LEU A 1 133 ? 7.63045  1.10863   9.63532   1.000 33.30053 ? 129 LEU A CA    1 ? 
ATOM   1038 C  C     . LEU A 1 133 ? 7.06872  -0.05492  10.44675  1.000 39.93169 ? 129 LEU A C     1 ? 
ATOM   1039 O  O     . LEU A 1 133 ? 7.21894  -0.08774  11.67242  1.000 36.02175 ? 129 LEU A O     1 ? 
ATOM   1040 C  CB    . LEU A 1 133 ? 9.14526  0.98433   9.47659   1.000 35.65001 ? 129 LEU A CB    1 ? 
ATOM   1041 C  CG    . LEU A 1 133 ? 9.59930  -0.13154  8.53862   1.000 47.04060 ? 129 LEU A CG    1 ? 
ATOM   1042 C  CD1   . LEU A 1 133 ? 9.31375  0.25358   7.09604   1.000 54.27965 ? 129 LEU A CD1   1 ? 
ATOM   1043 C  CD2   . LEU A 1 133 ? 11.07087 -0.43898  8.73691   1.000 49.00890 ? 129 LEU A CD2   1 ? 
ATOM   1044 N  N     . ARG A 1 134 ? 6.40676  -1.00008  9.76361   1.000 36.01332 ? 130 ARG A N     1 ? 
ATOM   1045 C  CA    . ARG A 1 134 ? 5.78115  -2.15997  10.39568  1.000 37.91253 ? 130 ARG A CA    1 ? 
ATOM   1046 C  C     . ARG A 1 134 ? 6.19867  -3.43833  9.69051   1.000 39.77549 ? 130 ARG A C     1 ? 
ATOM   1047 O  O     . ARG A 1 134 ? 6.28447  -3.48087  8.46068   1.000 40.60304 ? 130 ARG A O     1 ? 
ATOM   1048 C  CB    . ARG A 1 134 ? 4.25240  -2.06747  10.37440  1.000 39.24271 ? 130 ARG A CB    1 ? 
ATOM   1049 C  CG    . ARG A 1 134 ? 3.71087  -1.04599  11.32186  1.000 38.57948 ? 130 ARG A CG    1 ? 
ATOM   1050 C  CD    . ARG A 1 134 ? 2.22884  -0.81485  11.13033  1.000 37.67967 ? 130 ARG A CD    1 ? 
ATOM   1051 N  NE    . ARG A 1 134 ? 1.83273  0.36607   11.88472  1.000 39.58178 ? 130 ARG A NE    1 ? 
ATOM   1052 C  CZ    . ARG A 1 134 ? 1.68109  0.39529   13.20127  1.000 42.68101 ? 130 ARG A CZ    1 ? 
ATOM   1053 N  NH1   . ARG A 1 134 ? 1.77244  -0.70899  13.93508  1.000 42.95125 ? 130 ARG A NH1   1 ? 
ATOM   1054 N  NH2   . ARG A 1 134 ? 1.45272  1.56135   13.79993  1.000 42.14675 ? 130 ARG A NH2   1 ? 
ATOM   1055 N  N     . GLY A 1 135 ? 6.43079  -4.48314  10.47829  1.000 42.19690 ? 131 GLY A N     1 ? 
ATOM   1056 C  CA    . GLY A 1 135 ? 6.81857  -5.76831  9.95426   1.000 43.24723 ? 131 GLY A CA    1 ? 
ATOM   1057 C  C     . GLY A 1 135 ? 5.62274  -6.55717  9.46603   1.000 48.23240 ? 131 GLY A C     1 ? 
ATOM   1058 O  O     . GLY A 1 135 ? 4.48762  -6.06520  9.46128   1.000 45.89014 ? 131 GLY A O     1 ? 
ATOM   1059 N  N     . PRO A 1 136 ? 5.85566  -7.81140  9.05711   1.000 49.96310 ? 132 PRO A N     1 ? 
ATOM   1060 C  CA    . PRO A 1 136 ? 4.75861  -8.61554  8.49251   1.000 51.56129 ? 132 PRO A CA    1 ? 
ATOM   1061 C  C     . PRO A 1 136 ? 3.71728  -9.01025  9.52051   1.000 51.02057 ? 132 PRO A C     1 ? 
ATOM   1062 O  O     . PRO A 1 136 ? 2.56282  -9.26157  9.14864   1.000 48.07031 ? 132 PRO A O     1 ? 
ATOM   1063 C  CB    . PRO A 1 136 ? 5.48100  -9.84412  7.92264   1.000 52.17664 ? 132 PRO A CB    1 ? 
ATOM   1064 C  CG    . PRO A 1 136 ? 6.69299  -9.98983  8.78749   1.000 51.01343 ? 132 PRO A CG    1 ? 
ATOM   1065 C  CD    . PRO A 1 136 ? 7.10782  -8.58387  9.17850   1.000 51.02492 ? 132 PRO A CD    1 ? 
ATOM   1066 N  N     . ASP A 1 137 ? 4.08624  -9.06221  10.80132  1.000 49.96162 ? 133 ASP A N     1 ? 
ATOM   1067 C  CA    . ASP A 1 137 ? 3.11640  -9.27771  11.86565  1.000 50.98736 ? 133 ASP A CA    1 ? 
ATOM   1068 C  C     . ASP A 1 137 ? 2.27036  -8.04493  12.15411  1.000 47.99743 ? 133 ASP A C     1 ? 
ATOM   1069 O  O     . ASP A 1 137 ? 1.32072  -8.14375  12.93751  1.000 45.48150 ? 133 ASP A O     1 ? 
ATOM   1070 C  CB    . ASP A 1 137 ? 3.83643  -9.72454  13.14174  1.000 52.96889 ? 133 ASP A CB    1 ? 
ATOM   1071 C  CG    . ASP A 1 137 ? 5.03481  -8.83612  13.49436  1.000 57.25563 ? 133 ASP A CG    1 ? 
ATOM   1072 O  OD1   . ASP A 1 137 ? 5.21868  -7.75905  12.87234  1.000 51.62883 ? 133 ASP A OD1   1 ? 
ATOM   1073 O  OD2   . ASP A 1 137 ? 5.80074  -9.22998  14.40333  1.000 62.86406 ? 133 ASP A OD2   1 ? 
ATOM   1074 N  N     . GLY A 1 138 ? 2.58975  -6.89939  11.54637  1.000 47.27994 ? 134 GLY A N     1 ? 
ATOM   1075 C  CA    . GLY A 1 138 ? 1.89135  -5.65500  11.78847  1.000 43.48640 ? 134 GLY A CA    1 ? 
ATOM   1076 C  C     . GLY A 1 138 ? 2.40229  -4.85534  12.96737  1.000 45.40019 ? 134 GLY A C     1 ? 
ATOM   1077 O  O     . GLY A 1 138 ? 1.91892  -3.73885  13.20065  1.000 41.17372 ? 134 GLY A O     1 ? 
ATOM   1078 N  N     . LEU A 1 139 ? 3.35326  -5.38926  13.72235  1.000 47.24011 ? 135 LEU A N     1 ? 
ATOM   1079 C  CA    . LEU A 1 139 ? 3.88590  -4.67056  14.86760  1.000 46.43918 ? 135 LEU A CA    1 ? 
ATOM   1080 C  C     . LEU A 1 139 ? 4.80952  -3.54692  14.39962  1.000 40.58916 ? 135 LEU A C     1 ? 
ATOM   1081 O  O     . LEU A 1 139 ? 5.53251  -3.68988  13.40787  1.000 37.48198 ? 135 LEU A O     1 ? 
ATOM   1082 C  CB    . LEU A 1 139 ? 4.63756  -5.64078  15.77867  1.000 47.16694 ? 135 LEU A CB    1 ? 
ATOM   1083 C  CG    . LEU A 1 139 ? 4.65627  -5.34054  17.27580  1.000 53.43858 ? 135 LEU A CG    1 ? 
ATOM   1084 C  CD1   . LEU A 1 139 ? 3.24615  -5.49200  17.86280  1.000 54.46545 ? 135 LEU A CD1   1 ? 
ATOM   1085 C  CD2   . LEU A 1 139 ? 5.66385  -6.25286  17.98108  1.000 54.54826 ? 135 LEU A CD2   1 ? 
ATOM   1086 N  N     . SER A 1 140 ? 4.76790  -2.41823  15.10534  1.000 38.86343 ? 136 SER A N     1 ? 
ATOM   1087 C  CA    . SER A 1 140 ? 5.69458  -1.33131  14.80739  1.000 38.82786 ? 136 SER A CA    1 ? 
ATOM   1088 C  C     . SER A 1 140 ? 7.13235  -1.79513  14.99778  1.000 37.84673 ? 136 SER A C     1 ? 
ATOM   1089 O  O     . SER A 1 140 ? 7.45208  -2.48164  15.97054  1.000 38.23291 ? 136 SER A O     1 ? 
ATOM   1090 C  CB    . SER A 1 140 ? 5.42304  -0.13231  15.70782  1.000 38.68177 ? 136 SER A CB    1 ? 
ATOM   1091 O  OG    . SER A 1 140 ? 6.49235  0.78657   15.62969  1.000 38.34493 ? 136 SER A OG    1 ? 
ATOM   1092 N  N     . ARG A 1 141 ? 8.00110  -1.43381  14.05313  1.000 36.07484 ? 137 ARG A N     1 ? 
ATOM   1093 C  CA    . ARG A 1 141 ? 9.41682  -1.74760  14.16736  1.000 35.89988 ? 137 ARG A CA    1 ? 
ATOM   1094 C  C     . ARG A 1 141 ? 10.20590 -0.66600  14.90452  1.000 35.84835 ? 137 ARG A C     1 ? 
ATOM   1095 O  O     . ARG A 1 141 ? 11.44021 -0.70128  14.89777  1.000 33.78032 ? 137 ARG A O     1 ? 
ATOM   1096 C  CB    . ARG A 1 141 ? 10.01502 -1.98808  12.78066  1.000 36.51416 ? 137 ARG A CB    1 ? 
ATOM   1097 C  CG    . ARG A 1 141 ? 9.45658  -3.22212  12.10669  1.000 39.75547 ? 137 ARG A CG    1 ? 
ATOM   1098 C  CD    . ARG A 1 141 ? 9.98000  -3.36003  10.69681  1.000 42.99844 ? 137 ARG A CD    1 ? 
ATOM   1099 N  NE    . ARG A 1 141 ? 11.35994 -3.82060  10.66691  1.000 44.89811 ? 137 ARG A NE    1 ? 
ATOM   1100 C  CZ    . ARG A 1 141 ? 12.06798 -3.96932  9.55451   1.000 48.33377 ? 137 ARG A CZ    1 ? 
ATOM   1101 N  NH1   . ARG A 1 141 ? 11.54955 -3.70668  8.36319   1.000 51.70113 ? 137 ARG A NH1   1 ? 
ATOM   1102 N  NH2   . ARG A 1 141 ? 13.32640 -4.39253  9.63765   1.000 47.11290 ? 137 ARG A NH2   1 ? 
ATOM   1103 N  N     . GLY A 1 142 ? 9.52620  0.28963   15.52597  1.000 34.05089 ? 138 GLY A N     1 ? 
ATOM   1104 C  CA    . GLY A 1 142 ? 10.20555 1.28437   16.33318  1.000 33.75029 ? 138 GLY A CA    1 ? 
ATOM   1105 C  C     . GLY A 1 142 ? 10.96382 2.31312   15.52998  1.000 35.55775 ? 138 GLY A C     1 ? 
ATOM   1106 O  O     . GLY A 1 142 ? 11.92130 2.90347   16.04110  1.000 32.86986 ? 138 GLY A O     1 ? 
ATOM   1107 N  N     . CYS A 1 143 ? 10.56117 2.54723   14.28042  1.000 33.58898 ? 139 CYS A N     1 ? 
ATOM   1108 C  CA    . CYS A 1 143 ? 11.23827 3.51354   13.42602  1.000 30.06717 ? 139 CYS A CA    1 ? 
ATOM   1109 C  C     . CYS A 1 143 ? 10.25058 4.03526   12.39011  1.000 31.54936 ? 139 CYS A C     1 ? 
ATOM   1110 O  O     . CYS A 1 143 ? 9.16974  3.47123   12.17852  1.000 30.78925 ? 139 CYS A O     1 ? 
ATOM   1111 C  CB    . CYS A 1 143 ? 12.47006 2.89585   12.76073  1.000 28.68898 ? 139 CYS A CB    1 ? 
ATOM   1112 S  SG    . CYS A 1 143 ? 12.13341 1.38736   11.87971  1.000 34.48556 ? 139 CYS A SG    1 ? 
ATOM   1113 N  N     . ALA A 1 144 ? 10.63964 5.12763   11.74640  1.000 28.94209 ? 140 ALA A N     1 ? 
ATOM   1114 C  CA    . ALA A 1 144 ? 9.75525  5.82353   10.83128  1.000 29.90016 ? 140 ALA A CA    1 ? 
ATOM   1115 C  C     . ALA A 1 144 ? 10.59190 6.42621   9.72071   1.000 34.02075 ? 140 ALA A C     1 ? 
ATOM   1116 O  O     . ALA A 1 144 ? 11.80554 6.58630   9.85349   1.000 29.07597 ? 140 ALA A O     1 ? 
ATOM   1117 C  CB    . ALA A 1 144 ? 8.95843  6.91675   11.54204  1.000 31.48161 ? 140 ALA A CB    1 ? 
ATOM   1118 N  N     . PHE A 1 145 ? 9.92819  6.75684   8.61817   1.000 29.02174 ? 141 PHE A N     1 ? 
ATOM   1119 C  CA    . PHE A 1 145 ? 10.53213 7.53817   7.55083   1.000 31.81483 ? 141 PHE A CA    1 ? 
ATOM   1120 C  C     . PHE A 1 145 ? 9.82209  8.87785   7.49154   1.000 36.23580 ? 141 PHE A C     1 ? 
ATOM   1121 O  O     . PHE A 1 145 ? 8.58831  8.92902   7.54842   1.000 36.39521 ? 141 PHE A O     1 ? 
ATOM   1122 C  CB    . PHE A 1 145 ? 10.44062 6.81654   6.20704   1.000 35.61854 ? 141 PHE A CB    1 ? 
ATOM   1123 C  CG    . PHE A 1 145 ? 11.41534 5.69215   6.06421   1.000 38.82739 ? 141 PHE A CG    1 ? 
ATOM   1124 C  CD1   . PHE A 1 145 ? 11.00834 4.45679   5.61055   1.000 49.23812 ? 141 PHE A CD1   1 ? 
ATOM   1125 C  CD2   . PHE A 1 145 ? 12.74794 5.87633   6.38166   1.000 36.85294 ? 141 PHE A CD2   1 ? 
ATOM   1126 C  CE1   . PHE A 1 145 ? 11.91585 3.42162   5.48288   1.000 57.24410 ? 141 PHE A CE1   1 ? 
ATOM   1127 C  CE2   . PHE A 1 145 ? 13.65380 4.84995   6.25260   1.000 47.08692 ? 141 PHE A CE2   1 ? 
ATOM   1128 C  CZ    . PHE A 1 145 ? 13.24267 3.62229   5.80413   1.000 49.18840 ? 141 PHE A CZ    1 ? 
ATOM   1129 N  N     . VAL A 1 146 ? 10.59742 9.95459   7.39805   1.000 30.83699 ? 142 VAL A N     1 ? 
ATOM   1130 C  CA    . VAL A 1 146 ? 10.06246 11.30558  7.26506   1.000 33.46392 ? 142 VAL A CA    1 ? 
ATOM   1131 C  C     . VAL A 1 146 ? 10.70109 11.94247  6.04042   1.000 35.14894 ? 142 VAL A C     1 ? 
ATOM   1132 O  O     . VAL A 1 146 ? 11.92599 12.07912  5.97653   1.000 32.46844 ? 142 VAL A O     1 ? 
ATOM   1133 C  CB    . VAL A 1 146 ? 10.32207 12.16148  8.51306   1.000 33.77906 ? 142 VAL A CB    1 ? 
ATOM   1134 C  CG1   . VAL A 1 146 ? 9.77752  13.58305  8.32310   1.000 35.38877 ? 142 VAL A CG1   1 ? 
ATOM   1135 C  CG2   . VAL A 1 146 ? 9.67269  11.51247  9.73004   1.000 35.43060 ? 142 VAL A CG2   1 ? 
ATOM   1136 N  N     . THR A 1 147 ? 9.87572  12.34140  5.07777   1.000 37.41626 ? 143 THR A N     1 ? 
ATOM   1137 C  CA    . THR A 1 147 ? 10.34222 13.01724  3.87576   1.000 34.98718 ? 143 THR A CA    1 ? 
ATOM   1138 C  C     . THR A 1 147 ? 9.97122  14.48980  3.97991   1.000 38.63144 ? 143 THR A C     1 ? 
ATOM   1139 O  O     . THR A 1 147 ? 8.79819  14.82333  4.16990   1.000 38.93860 ? 143 THR A O     1 ? 
ATOM   1140 C  CB    . THR A 1 147 ? 9.72506  12.39884  2.62177   1.000 36.88710 ? 143 THR A CB    1 ? 
ATOM   1141 O  OG1   . THR A 1 147 ? 10.05438 11.01036  2.55912   1.000 41.03860 ? 143 THR A OG1   1 ? 
ATOM   1142 C  CG2   . THR A 1 147 ? 10.25288 13.09721  1.37564   1.000 36.97091 ? 143 THR A CG2   1 ? 
ATOM   1143 N  N     . PHE A 1 148 ? 10.96590 15.36306  3.88029   1.000 33.69972 ? 144 PHE A N     1 ? 
ATOM   1144 C  CA    . PHE A 1 148 ? 10.70902 16.78922  3.81164   1.000 36.37052 ? 144 PHE A CA    1 ? 
ATOM   1145 C  C     . PHE A 1 148 ? 10.64981 17.23635  2.35346   1.000 35.52208 ? 144 PHE A C     1 ? 
ATOM   1146 O  O     . PHE A 1 148 ? 10.99018 16.49212  1.43600   1.000 35.16611 ? 144 PHE A O     1 ? 
ATOM   1147 C  CB    . PHE A 1 148 ? 11.77852 17.56444  4.57657   1.000 35.15906 ? 144 PHE A CB    1 ? 
ATOM   1148 C  CG    . PHE A 1 148 ? 11.64312 17.46989  6.06912   1.000 36.63045 ? 144 PHE A CG    1 ? 
ATOM   1149 C  CD1   . PHE A 1 148 ? 10.81823 18.34766  6.75896   1.000 38.03453 ? 144 PHE A CD1   1 ? 
ATOM   1150 C  CD2   . PHE A 1 148 ? 12.33153 16.49464  6.78220   1.000 35.88496 ? 144 PHE A CD2   1 ? 
ATOM   1151 C  CE1   . PHE A 1 148 ? 10.68583 18.26607  8.12708   1.000 39.39023 ? 144 PHE A CE1   1 ? 
ATOM   1152 C  CE2   . PHE A 1 148 ? 12.20475 16.40496  8.15874   1.000 33.92065 ? 144 PHE A CE2   1 ? 
ATOM   1153 C  CZ    . PHE A 1 148 ? 11.38314 17.28873  8.83305   1.000 35.12293 ? 144 PHE A CZ    1 ? 
ATOM   1154 N  N     . SER A 1 149 ? 10.20034 18.47194  2.14042   1.000 39.61793 ? 145 SER A N     1 ? 
ATOM   1155 C  CA    . SER A 1 149 ? 10.14162 18.97878  0.77620   1.000 40.84743 ? 145 SER A CA    1 ? 
ATOM   1156 C  C     . SER A 1 149 ? 11.49930 19.44713  0.25891   1.000 40.17040 ? 145 SER A C     1 ? 
ATOM   1157 O  O     . SER A 1 149 ? 11.69411 19.47708  -0.96123  1.000 40.11687 ? 145 SER A O     1 ? 
ATOM   1158 C  CB    . SER A 1 149 ? 9.11061  20.10889  0.67082   1.000 41.23095 ? 145 SER A CB    1 ? 
ATOM   1159 O  OG    . SER A 1 149 ? 9.40779  21.16653  1.56066   1.000 44.29276 ? 145 SER A OG    1 ? 
ATOM   1160 N  N     . THR A 1 150 ? 12.44207 19.80422  1.13871   1.000 38.76700 ? 146 THR A N     1 ? 
ATOM   1161 C  CA    . THR A 1 150 ? 13.79188 20.16144  0.71032   1.000 36.95745 ? 146 THR A CA    1 ? 
ATOM   1162 C  C     . THR A 1 150 ? 14.82473 19.48952  1.60507   1.000 37.69813 ? 146 THR A C     1 ? 
ATOM   1163 O  O     . THR A 1 150 ? 14.54792 19.13285  2.75263   1.000 35.24994 ? 146 THR A O     1 ? 
ATOM   1164 C  CB    . THR A 1 150 ? 14.04388 21.67587  0.72772   1.000 38.97213 ? 146 THR A CB    1 ? 
ATOM   1165 O  OG1   . THR A 1 150 ? 14.32674 22.10615  2.06821   1.000 39.87084 ? 146 THR A OG1   1 ? 
ATOM   1166 C  CG2   . THR A 1 150 ? 12.84024 22.42991  0.19516   1.000 42.39592 ? 146 THR A CG2   1 ? 
ATOM   1167 N  N     . ARG A 1 151 ? 16.04130 19.35036  1.06849   1.000 34.81081 ? 147 ARG A N     1 ? 
ATOM   1168 C  CA    . ARG A 1 151 ? 17.12221 18.73503  1.83298   1.000 35.44132 ? 147 ARG A CA    1 ? 
ATOM   1169 C  C     . ARG A 1 151 ? 17.54074 19.60508  3.01108   1.000 35.03676 ? 147 ARG A C     1 ? 
ATOM   1170 O  O     . ARG A 1 151 ? 17.92689 19.08466  4.06830   1.000 32.71357 ? 147 ARG A O     1 ? 
ATOM   1171 C  CB    . ARG A 1 151 ? 18.32213 18.45580  0.92909   1.000 34.95672 ? 147 ARG A CB    1 ? 
ATOM   1172 C  CG    . ARG A 1 151 ? 19.49531 17.86954  1.69135   1.000 36.62619 ? 147 ARG A CG    1 ? 
ATOM   1173 C  CD    . ARG A 1 151 ? 20.54287 17.32369  0.77199   1.000 36.45893 ? 147 ARG A CD    1 ? 
ATOM   1174 N  NE    . ARG A 1 151 ? 21.73074 16.91120  1.50627   1.000 34.19726 ? 147 ARG A NE    1 ? 
ATOM   1175 C  CZ    . ARG A 1 151 ? 21.99161 15.66308  1.86670   1.000 35.95757 ? 147 ARG A CZ    1 ? 
ATOM   1176 N  NH1   . ARG A 1 151 ? 21.16750 14.67203  1.57254   1.000 39.99819 ? 147 ARG A NH1   1 ? 
ATOM   1177 N  NH2   . ARG A 1 151 ? 23.11429 15.40049  2.53146   1.000 38.64496 ? 147 ARG A NH2   1 ? 
ATOM   1178 N  N     . ALA A 1 152 ? 17.47937 20.93014  2.84886   1.000 33.77315 ? 148 ALA A N     1 ? 
ATOM   1179 C  CA    . ALA A 1 152 ? 17.83303 21.82236  3.94928   1.000 35.90888 ? 148 ALA A CA    1 ? 
ATOM   1180 C  C     . ALA A 1 152 ? 16.94256 21.58631  5.16254   1.000 33.74224 ? 148 ALA A C     1 ? 
ATOM   1181 O  O     . ALA A 1 152 ? 17.41895 21.60948  6.30178   1.000 35.27908 ? 148 ALA A O     1 ? 
ATOM   1182 C  CB    . ALA A 1 152 ? 17.73770 23.28096  3.50078   1.000 37.58734 ? 148 ALA A CB    1 ? 
ATOM   1183 N  N     . MET A 1 153 ? 15.64175 21.37461  4.93818   1.000 37.36277 ? 149 MET A N     1 ? 
ATOM   1184 C  CA    . MET A 1 153 ? 14.73514 21.06730  6.04272   1.000 35.78044 ? 149 MET A CA    1 ? 
ATOM   1185 C  C     . MET A 1 153 ? 15.17860 19.80399  6.77009   1.000 34.74749 ? 149 MET A C     1 ? 
ATOM   1186 O  O     . MET A 1 153 ? 15.24257 19.76623  8.00587   1.000 33.61738 ? 149 MET A O     1 ? 
ATOM   1187 C  CB    . MET A 1 153 ? 13.30813 20.88875  5.52353   1.000 36.94520 ? 149 MET A CB    1 ? 
ATOM   1188 C  CG    . MET A 1 153 ? 12.66486 22.15382  4.99311   1.000 39.97620 ? 149 MET A CG    1 ? 
ATOM   1189 S  SD    . MET A 1 153 ? 11.16665 21.75495  4.07483   1.000 44.49638 ? 149 MET A SD    1 ? 
ATOM   1190 C  CE    . MET A 1 153 ? 10.71140 23.40242  3.52820   1.000 41.64266 ? 149 MET A CE    1 ? 
ATOM   1191 N  N     . ALA A 1 154 ? 15.48640 18.75591  6.00890   1.000 30.46211 ? 150 ALA A N     1 ? 
ATOM   1192 C  CA    . ALA A 1 154 ? 15.92291 17.50079  6.61173   1.000 32.32909 ? 150 ALA A CA    1 ? 
ATOM   1193 C  C     . ALA A 1 154 ? 17.19296 17.69653  7.43337   1.000 32.35918 ? 150 ALA A C     1 ? 
ATOM   1194 O  O     . ALA A 1 154 ? 17.31572 17.16888  8.54647   1.000 30.99706 ? 150 ALA A O     1 ? 
ATOM   1195 C  CB    . ALA A 1 154 ? 16.13340 16.45321  5.52064   1.000 28.46574 ? 150 ALA A CB    1 ? 
ATOM   1196 N  N     . GLN A 1 155 ? 18.15032 18.46001  6.90446   1.000 30.48205 ? 151 GLN A N     1 ? 
ATOM   1197 C  CA    . GLN A 1 155 ? 19.40075 18.66485  7.63059   1.000 33.53515 ? 151 GLN A CA    1 ? 
ATOM   1198 C  C     . GLN A 1 155 ? 19.16586 19.41668  8.93803   1.000 33.19577 ? 151 GLN A C     1 ? 
ATOM   1199 O  O     . GLN A 1 155 ? 19.80961 19.12826  9.95446   1.000 33.69060 ? 151 GLN A O     1 ? 
ATOM   1200 C  CB    . GLN A 1 155 ? 20.40791 19.41219  6.75237   1.000 33.63360 ? 151 GLN A CB    1 ? 
ATOM   1201 C  CG    . GLN A 1 155 ? 21.70705 19.75449  7.48422   1.000 38.90721 ? 151 GLN A CG    1 ? 
ATOM   1202 C  CD    . GLN A 1 155 ? 22.37171 18.52405  8.13291   1.000 46.01744 ? 151 GLN A CD    1 ? 
ATOM   1203 O  OE1   . GLN A 1 155 ? 22.51159 18.44873  9.36774   1.000 40.72127 ? 151 GLN A OE1   1 ? 
ATOM   1204 N  NE2   . GLN A 1 155 ? 22.78775 17.55969  7.29995   1.000 41.23569 ? 151 GLN A NE2   1 ? 
ATOM   1205 N  N     . ASN A 1 156 ? 18.26123 20.39697  8.93162   1.000 33.14709 ? 152 ASN A N     1 ? 
ATOM   1206 C  CA    . ASN A 1 156 ? 17.98364 21.12597  10.16484  1.000 34.50485 ? 152 ASN A CA    1 ? 
ATOM   1207 C  C     . ASN A 1 156 ? 17.32708 20.21664  11.19200  1.000 32.26499 ? 152 ASN A C     1 ? 
ATOM   1208 O  O     . ASN A 1 156 ? 17.59268 20.33473  12.39343  1.000 33.00255 ? 152 ASN A O     1 ? 
ATOM   1209 C  CB    . ASN A 1 156 ? 17.10083 22.33773  9.88378   1.000 35.80915 ? 152 ASN A CB    1 ? 
ATOM   1210 C  CG    . ASN A 1 156 ? 17.81962 23.38537  9.07398   1.000 38.54842 ? 152 ASN A CG    1 ? 
ATOM   1211 O  OD1   . ASN A 1 156 ? 19.04632 23.47491  9.12160   1.000 39.47381 ? 152 ASN A OD1   1 ? 
ATOM   1212 N  ND2   . ASN A 1 156 ? 17.06732 24.17508  8.31469   1.000 38.66904 ? 152 ASN A ND2   1 ? 
ATOM   1213 N  N     . ALA A 1 157 ? 16.48273 19.29668  10.72796  1.000 31.41246 ? 153 ALA A N     1 ? 
ATOM   1214 C  CA    . ALA A 1 157 ? 15.86287 18.33036  11.62659  1.000 32.50661 ? 153 ALA A CA    1 ? 
ATOM   1215 C  C     . ALA A 1 157 ? 16.90332 17.40687  12.25020  1.000 31.45090 ? 153 ALA A C     1 ? 
ATOM   1216 O  O     . ALA A 1 157 ? 16.80672 17.07255  13.43771  1.000 32.34650 ? 153 ALA A O     1 ? 
ATOM   1217 C  CB    . ALA A 1 157 ? 14.80545 17.52284  10.87531  1.000 33.13021 ? 153 ALA A CB    1 ? 
ATOM   1218 N  N     . ILE A 1 158 ? 17.90513 16.97964  11.46744  1.000 27.46780 ? 154 ILE A N     1 ? 
ATOM   1219 C  CA    . ILE A 1 158 ? 18.96870 16.13920  12.01917  1.000 29.12675 ? 154 ILE A CA    1 ? 
ATOM   1220 C  C     . ILE A 1 158 ? 19.70659 16.87611  13.12923  1.000 32.30188 ? 154 ILE A C     1 ? 
ATOM   1221 O  O     . ILE A 1 158 ? 19.90904 16.34592  14.23047  1.000 30.40765 ? 154 ILE A O     1 ? 
ATOM   1222 C  CB    . ILE A 1 158 ? 19.94871 15.69741  10.91671  1.000 30.43808 ? 154 ILE A CB    1 ? 
ATOM   1223 C  CG1   . ILE A 1 158 ? 19.25357 14.81630  9.87370   1.000 29.45401 ? 154 ILE A CG1   1 ? 
ATOM   1224 C  CG2   . ILE A 1 158 ? 21.13969 14.97781  11.53465  1.000 31.90660 ? 154 ILE A CG2   1 ? 
ATOM   1225 C  CD1   . ILE A 1 158 ? 20.12398 14.52314  8.66407   1.000 32.45665 ? 154 ILE A CD1   1 ? 
ATOM   1226 N  N     . LYS A 1 159 ? 20.15158 18.10134  12.84526  1.000 30.94926 ? 155 LYS A N     1 ? 
ATOM   1227 C  CA    . LYS A 1 159 ? 20.95436 18.82230  13.82368  1.000 31.96677 ? 155 LYS A CA    1 ? 
ATOM   1228 C  C     . LYS A 1 159 ? 20.16569 19.05574  15.10554  1.000 31.14612 ? 155 LYS A C     1 ? 
ATOM   1229 O  O     . LYS A 1 159 ? 20.72682 19.02263  16.21008  1.000 32.96896 ? 155 LYS A O     1 ? 
ATOM   1230 C  CB    . LYS A 1 159 ? 21.43402 20.15037  13.23043  1.000 34.81150 ? 155 LYS A CB    1 ? 
ATOM   1231 C  CG    . LYS A 1 159 ? 22.31785 20.96674  14.16895  1.000 37.17924 ? 155 LYS A CG    1 ? 
ATOM   1232 C  CD    . LYS A 1 159 ? 22.63856 22.34233  13.58241  1.000 45.50249 ? 155 LYS A CD    1 ? 
ATOM   1233 C  CE    . LYS A 1 159 ? 23.42834 23.21931  14.55863  1.000 45.48037 ? 155 LYS A CE    1 ? 
ATOM   1234 N  NZ    . LYS A 1 159 ? 24.85217 22.78900  14.72082  1.000 47.65701 ? 155 LYS A NZ    1 ? 
ATOM   1235 N  N     . ALA A 1 160 ? 18.86233 19.27109  14.98125  1.000 28.65763 ? 156 ALA A N     1 ? 
ATOM   1236 C  CA    . ALA A 1 160 ? 18.05676 19.64050  16.13456  1.000 30.76504 ? 156 ALA A CA    1 ? 
ATOM   1237 C  C     . ALA A 1 160 ? 17.48524 18.44220  16.87344  1.000 33.89067 ? 156 ALA A C     1 ? 
ATOM   1238 O  O     . ALA A 1 160 ? 17.15202 18.56268  18.05922  1.000 31.99890 ? 156 ALA A O     1 ? 
ATOM   1239 C  CB    . ALA A 1 160 ? 16.90446 20.55120  15.71021  1.000 31.54031 ? 156 ALA A CB    1 ? 
ATOM   1240 N  N     . MET A 1 161 ? 17.34189 17.29928  16.20530  1.000 29.59182 ? 157 MET A N     1 ? 
ATOM   1241 C  CA    . MET A 1 161 ? 16.60269 16.18998  16.78599  1.000 27.17715 ? 157 MET A CA    1 ? 
ATOM   1242 C  C     . MET A 1 161 ? 17.43550 14.94730  17.02807  1.000 26.44011 ? 157 MET A C     1 ? 
ATOM   1243 O  O     . MET A 1 161 ? 17.03728 14.13467  17.86315  1.000 26.59954 ? 157 MET A O     1 ? 
ATOM   1244 C  CB    . MET A 1 161 ? 15.40305 15.81056  15.90263  1.000 27.50008 ? 157 MET A CB    1 ? 
ATOM   1245 C  CG    . MET A 1 161 ? 14.35030 16.89907  15.79041  1.000 34.15813 ? 157 MET A CG    1 ? 
ATOM   1246 S  SD    . MET A 1 161 ? 13.48197 17.20001  17.35244  1.000 36.11456 ? 157 MET A SD    1 ? 
ATOM   1247 C  CE    . MET A 1 161 ? 12.39474 15.77582  17.36700  1.000 39.18085 ? 157 MET A CE    1 ? 
ATOM   1248 N  N     . HIS A 1 162 ? 18.56785 14.76851  16.33872  1.000 24.45812 ? 158 HIS A N     1 ? 
ATOM   1249 C  CA    . HIS A 1 162 ? 19.31783 13.52894  16.50559  1.000 24.48687 ? 158 HIS A CA    1 ? 
ATOM   1250 C  C     . HIS A 1 162 ? 19.78778 13.40889  17.95302  1.000 28.88104 ? 158 HIS A C     1 ? 
ATOM   1251 O  O     . HIS A 1 162 ? 20.42781 14.32122  18.48470  1.000 27.00122 ? 158 HIS A O     1 ? 
ATOM   1252 C  CB    . HIS A 1 162 ? 20.50707 13.47239  15.53273  1.000 25.62016 ? 158 HIS A CB    1 ? 
ATOM   1253 C  CG    . HIS A 1 162 ? 21.33312 12.22866  15.66121  1.000 27.43710 ? 158 HIS A CG    1 ? 
ATOM   1254 N  ND1   . HIS A 1 162 ? 20.80302 10.96174  15.52360  1.000 23.98087 ? 158 HIS A ND1   1 ? 
ATOM   1255 C  CD2   . HIS A 1 162 ? 22.64952 12.05682  15.92830  1.000 25.06754 ? 158 HIS A CD2   1 ? 
ATOM   1256 C  CE1   . HIS A 1 162 ? 21.75972 10.06516  15.69155  1.000 26.46782 ? 158 HIS A CE1   1 ? 
ATOM   1257 N  NE2   . HIS A 1 162 ? 22.89022 10.70346  15.94180  1.000 28.48980 ? 158 HIS A NE2   1 ? 
ATOM   1258 N  N     . GLN A 1 163 ? 19.41296 12.30147  18.59768  1.000 24.07769 ? 159 GLN A N     1 ? 
ATOM   1259 C  CA    . GLN A 1 163 ? 19.73629 12.02234  19.99693  1.000 25.21918 ? 159 GLN A CA    1 ? 
ATOM   1260 C  C     . GLN A 1 163 ? 19.31094 13.14812  20.93618  1.000 26.58761 ? 159 GLN A C     1 ? 
ATOM   1261 O  O     . GLN A 1 163 ? 19.92727 13.36116  21.98067  1.000 28.52906 ? 159 GLN A O     1 ? 
ATOM   1262 C  CB    . GLN A 1 163 ? 21.21786 11.70702  20.16147  1.000 23.98436 ? 159 GLN A CB    1 ? 
ATOM   1263 C  CG    . GLN A 1 163 ? 21.62272 10.49640  19.34580  1.000 23.41797 ? 159 GLN A CG    1 ? 
ATOM   1264 C  CD    . GLN A 1 163 ? 22.99913 10.02000  19.69606  1.000 27.13770 ? 159 GLN A CD    1 ? 
ATOM   1265 O  OE1   . GLN A 1 163 ? 23.95455 10.79209  19.64171  1.000 25.59450 ? 159 GLN A OE1   1 ? 
ATOM   1266 N  NE2   . GLN A 1 163 ? 23.12076 8.73898   20.05192  1.000 25.42037 ? 159 GLN A NE2   1 ? 
ATOM   1267 N  N     . SER A 1 164 ? 18.21597 13.82510  20.60165  1.000 26.09175 ? 160 SER A N     1 ? 
ATOM   1268 C  CA    . SER A 1 164 ? 17.71566 14.93393  21.40604  1.000 28.82445 ? 160 SER A CA    1 ? 
ATOM   1269 C  C     . SER A 1 164 ? 16.89377 14.46845  22.59988  1.000 32.14127 ? 160 SER A C     1 ? 
ATOM   1270 O  O     . SER A 1 164 ? 16.63363 15.25926  23.51352  1.000 29.45179 ? 160 SER A O     1 ? 
ATOM   1271 C  CB    . SER A 1 164 ? 16.87803 15.87042  20.53169  1.000 29.63473 ? 160 SER A CB    1 ? 
ATOM   1272 O  OG    . SER A 1 164 ? 15.70445 15.22748  20.06129  1.000 28.77180 ? 160 SER A OG    1 ? 
ATOM   1273 N  N     . GLN A 1 165 ? 16.49260 13.20635  22.62649  1.000 25.22494 ? 161 GLN A N     1 ? 
ATOM   1274 C  CA    . GLN A 1 165 ? 15.64319 12.71292  23.69650  1.000 25.47220 ? 161 GLN A CA    1 ? 
ATOM   1275 C  C     . GLN A 1 165 ? 15.62125 11.20666  23.55597  1.000 27.27525 ? 161 GLN A C     1 ? 
ATOM   1276 O  O     . GLN A 1 165 ? 15.99414 10.66507  22.51088  1.000 25.53299 ? 161 GLN A O     1 ? 
ATOM   1277 C  CB    . GLN A 1 165 ? 14.21314 13.27497  23.61981  1.000 29.62779 ? 161 GLN A CB    1 ? 
ATOM   1278 C  CG    . GLN A 1 165 ? 13.42810 12.80938  22.39006  1.000 29.79435 ? 161 GLN A CG    1 ? 
ATOM   1279 C  CD    . GLN A 1 165 ? 11.93237 13.08810  22.50526  1.000 36.62309 ? 161 GLN A CD    1 ? 
ATOM   1280 O  OE1   . GLN A 1 165 ? 11.17751 12.28241  23.05517  1.000 38.62454 ? 161 GLN A OE1   1 ? 
ATOM   1281 N  NE2   . GLN A 1 165 ? 11.50329 14.23406  21.99378  1.000 35.75618 ? 161 GLN A NE2   1 ? 
ATOM   1282 N  N     . THR A 1 166 ? 15.19629 10.53956  24.61954  1.000 24.71505 ? 162 THR A N     1 ? 
ATOM   1283 C  CA    . THR A 1 166 ? 14.93756 9.10601   24.58278  1.000 23.21921 ? 162 THR A CA    1 ? 
ATOM   1284 C  C     . THR A 1 166 ? 13.44908 8.91017   24.79160  1.000 25.68686 ? 162 THR A C     1 ? 
ATOM   1285 O  O     . THR A 1 166 ? 12.88199 9.43579   25.75315  1.000 25.63326 ? 162 THR A O     1 ? 
ATOM   1286 C  CB    . THR A 1 166 ? 15.71397 8.34745   25.66180  1.000 26.43082 ? 162 THR A CB    1 ? 
ATOM   1287 O  OG1   . THR A 1 166 ? 17.11198 8.56016   25.47533  1.000 24.45904 ? 162 THR A OG1   1 ? 
ATOM   1288 C  CG2   . THR A 1 166 ? 15.43505 6.84586   25.55288  1.000 23.25333 ? 162 THR A CG2   1 ? 
ATOM   1289 N  N     . MET A 1 167 ? 12.81978 8.17847   23.88592  1.000 26.08799 ? 163 MET A N     1 ? 
ATOM   1290 C  CA    . MET A 1 167 ? 11.39185 7.96316   23.98434  1.000 28.64312 ? 163 MET A CA    1 ? 
ATOM   1291 C  C     . MET A 1 167 ? 11.08631 6.78301   24.90093  1.000 27.72256 ? 163 MET A C     1 ? 
ATOM   1292 O  O     . MET A 1 167 ? 11.95502 5.97766   25.24986  1.000 26.96474 ? 163 MET A O     1 ? 
ATOM   1293 C  CB    . MET A 1 167 ? 10.80493 7.75000   22.59504  1.000 27.94775 ? 163 MET A CB    1 ? 
ATOM   1294 C  CG    . MET A 1 167 ? 11.23456 8.81459   21.61847  1.000 33.10878 ? 163 MET A CG    1 ? 
ATOM   1295 S  SD    . MET A 1 167 ? 10.07174 8.90284   20.24356  1.000 39.57872 ? 163 MET A SD    1 ? 
ATOM   1296 C  CE    . MET A 1 167 ? 8.75744  9.86448   21.01521  1.000 39.82001 ? 163 MET A CE    1 ? 
ATOM   1297 N  N     . GLU A 1 168 ? 9.81851  6.70556   25.29618  1.000 30.79011 ? 164 GLU A N     1 ? 
ATOM   1298 C  CA    . GLU A 1 168 ? 9.33704  5.66718   26.19529  1.000 32.38813 ? 164 GLU A CA    1 ? 
ATOM   1299 C  C     . GLU A 1 168 ? 9.68064  4.28547   25.66252  1.000 30.41967 ? 164 GLU A C     1 ? 
ATOM   1300 O  O     . GLU A 1 168 ? 9.39656  3.96525   24.50766  1.000 32.14030 ? 164 GLU A O     1 ? 
ATOM   1301 C  CB    . GLU A 1 168 ? 7.81969  5.81432   26.35119  1.000 37.40497 ? 164 GLU A CB    1 ? 
ATOM   1302 C  CG    . GLU A 1 168 ? 7.15833  4.90174   27.36212  1.000 44.46131 ? 164 GLU A CG    1 ? 
ATOM   1303 C  CD    . GLU A 1 168 ? 5.64172  4.86973   27.19433  1.000 57.50547 ? 164 GLU A CD    1 ? 
ATOM   1304 O  OE1   . GLU A 1 168 ? 5.15185  3.99034   26.45170  1.000 61.62344 ? 164 GLU A OE1   1 ? 
ATOM   1305 O  OE2   . GLU A 1 168 ? 4.94391  5.73085   27.78291  1.000 58.22655 ? 164 GLU A OE2   1 ? 
ATOM   1306 N  N     . GLY A 1 169 ? 10.29347 3.46372   26.50570  1.000 29.46080 ? 165 GLY A N     1 ? 
ATOM   1307 C  CA    . GLY A 1 169 ? 10.56916 2.09442   26.13025  1.000 30.04663 ? 165 GLY A CA    1 ? 
ATOM   1308 C  C     . GLY A 1 169 ? 11.77807 1.88896   25.24421  1.000 31.19578 ? 165 GLY A C     1 ? 
ATOM   1309 O  O     . GLY A 1 169 ? 12.07434 0.73835   24.89790  1.000 31.09456 ? 165 GLY A O     1 ? 
ATOM   1310 N  N     . CYS A 1 170 ? 12.50241 2.95241   24.88150  1.000 26.85789 ? 166 CYS A N     1 ? 
ATOM   1311 C  CA    . CYS A 1 170 ? 13.64564 2.85411   23.97830  1.000 26.78681 ? 166 CYS A CA    1 ? 
ATOM   1312 C  C     . CYS A 1 170 ? 14.96371 2.79474   24.73902  1.000 25.68874 ? 166 CYS A C     1 ? 
ATOM   1313 O  O     . CYS A 1 170 ? 15.17651 3.54220   25.69993  1.000 25.23452 ? 166 CYS A O     1 ? 
ATOM   1314 C  CB    . CYS A 1 170 ? 13.67872 4.03778   23.02065  1.000 24.27761 ? 166 CYS A CB    1 ? 
ATOM   1315 S  SG    . CYS A 1 170 ? 12.19060 4.11039   22.00121  1.000 31.50113 ? 166 CYS A SG    1 ? 
ATOM   1316 N  N     . SER A 1 171 ? 15.86806 1.93222   24.26520  1.000 24.25442 ? 167 SER A N     1 ? 
ATOM   1317 C  CA    . SER A 1 171 ? 17.16031 1.74820   24.91648  1.000 23.39119 ? 167 SER A CA    1 ? 
ATOM   1318 C  C     . SER A 1 171 ? 18.14606 2.87889   24.63915  1.000 26.41381 ? 167 SER A C     1 ? 
ATOM   1319 O  O     . SER A 1 171 ? 19.15932 2.98802   25.34504  1.000 25.98594 ? 167 SER A O     1 ? 
ATOM   1320 C  CB    . SER A 1 171 ? 17.78630 0.43247   24.46336  1.000 27.79639 ? 167 SER A CB    1 ? 
ATOM   1321 O  OG    . SER A 1 171 ? 18.07579 0.48891   23.07614  1.000 33.12695 ? 167 SER A OG    1 ? 
ATOM   1322 N  N     . SER A 1 172 ? 17.90637 3.68803   23.61824  1.000 24.38884 ? 168 SER A N     1 ? 
ATOM   1323 C  CA    . SER A 1 172 ? 18.88455 4.69634   23.22998  1.000 23.15266 ? 168 SER A CA    1 ? 
ATOM   1324 C  C     . SER A 1 172 ? 18.14643 5.91716   22.74736  1.000 23.15094 ? 168 SER A C     1 ? 
ATOM   1325 O  O     . SER A 1 172 ? 16.96178 5.83680   22.38391  1.000 22.65054 ? 168 SER A O     1 ? 
ATOM   1326 C  CB    . SER A 1 172 ? 19.82528 4.17893   22.13026  1.000 28.65903 ? 168 SER A CB    1 ? 
ATOM   1327 O  OG    . SER A 1 172 ? 20.55463 3.05543   22.57136  1.000 34.62186 ? 168 SER A OG    1 ? 
ATOM   1328 N  N     . PRO A 1 173 ? 18.80345 7.08280   22.72740  1.000 22.01967 ? 169 PRO A N     1 ? 
ATOM   1329 C  CA    . PRO A 1 173 ? 18.13873 8.30584   22.27863  1.000 23.22169 ? 169 PRO A CA    1 ? 
ATOM   1330 C  C     . PRO A 1 173 ? 17.71810 8.18907   20.82318  1.000 24.46815 ? 169 PRO A C     1 ? 
ATOM   1331 O  O     . PRO A 1 173 ? 18.26289 7.39823   20.05645  1.000 23.95972 ? 169 PRO A O     1 ? 
ATOM   1332 C  CB    . PRO A 1 173 ? 19.21401 9.38306   22.46244  1.000 23.07315 ? 169 PRO A CB    1 ? 
ATOM   1333 C  CG    . PRO A 1 173 ? 20.08103 8.85300   23.56635  1.000 23.98982 ? 169 PRO A CG    1 ? 
ATOM   1334 C  CD    . PRO A 1 173 ? 20.11692 7.35704   23.34430  1.000 21.12417 ? 169 PRO A CD    1 ? 
ATOM   1335 N  N     . ILE A 1 174 ? 16.73030 9.00187   20.45345  1.000 23.92340 ? 170 ILE A N     1 ? 
ATOM   1336 C  CA    . ILE A 1 174 ? 16.17832 8.95248   19.10339  1.000 24.70463 ? 170 ILE A CA    1 ? 
ATOM   1337 C  C     . ILE A 1 174 ? 17.28201 9.16698   18.07798  1.000 25.09766 ? 170 ILE A C     1 ? 
ATOM   1338 O  O     . ILE A 1 174 ? 18.16319 10.01436  18.26128  1.000 26.90501 ? 170 ILE A O     1 ? 
ATOM   1339 C  CB    . ILE A 1 174 ? 15.07762 10.01907  18.98876  1.000 25.93114 ? 170 ILE A CB    1 ? 
ATOM   1340 C  CG1   . ILE A 1 174 ? 14.31811 9.91872   17.67296  1.000 26.04184 ? 170 ILE A CG1   1 ? 
ATOM   1341 C  CG2   . ILE A 1 174 ? 15.67253 11.42857  19.16006  1.000 27.16252 ? 170 ILE A CG2   1 ? 
ATOM   1342 C  CD1   . ILE A 1 174 ? 13.10015 10.89051  17.62241  1.000 29.67921 ? 170 ILE A CD1   1 ? 
ATOM   1343 N  N     . VAL A 1 175 ? 17.27584 8.38300   17.00011  1.000 23.71187 ? 171 VAL A N     1 ? 
ATOM   1344 C  CA    . VAL A 1 175 ? 18.27011 8.59108   15.94593  1.000 26.09366 ? 171 VAL A CA    1 ? 
ATOM   1345 C  C     . VAL A 1 175 ? 17.57890 9.22782   14.74349  1.000 27.66277 ? 171 VAL A C     1 ? 
ATOM   1346 O  O     . VAL A 1 175 ? 16.44541 8.86784   14.38461  1.000 26.92898 ? 171 VAL A O     1 ? 
ATOM   1347 C  CB    . VAL A 1 175 ? 19.05785 7.31474   15.55560  1.000 32.11501 ? 171 VAL A CB    1 ? 
ATOM   1348 C  CG1   . VAL A 1 175 ? 18.97095 6.22906   16.61431  1.000 27.03359 ? 171 VAL A CG1   1 ? 
ATOM   1349 C  CG2   . VAL A 1 175 ? 18.73641 6.82698   14.17175  1.000 31.78782 ? 171 VAL A CG2   1 ? 
ATOM   1350 N  N     . VAL A 1 176 ? 18.23935 10.22901  14.16663  1.000 25.78263 ? 172 VAL A N     1 ? 
ATOM   1351 C  CA    . VAL A 1 176 ? 17.69494 11.01212  13.06373  1.000 26.02644 ? 172 VAL A CA    1 ? 
ATOM   1352 C  C     . VAL A 1 176 ? 18.83010 11.16356  12.06203  1.000 26.63125 ? 172 VAL A C     1 ? 
ATOM   1353 O  O     . VAL A 1 176 ? 19.84161 11.80558  12.36426  1.000 27.69209 ? 172 VAL A O     1 ? 
ATOM   1354 C  CB    . VAL A 1 176 ? 17.17433 12.38661  13.51634  1.000 26.93753 ? 172 VAL A CB    1 ? 
ATOM   1355 C  CG1   . VAL A 1 176 ? 16.49222 13.09743  12.36289  1.000 26.88621 ? 172 VAL A CG1   1 ? 
ATOM   1356 C  CG2   . VAL A 1 176 ? 16.20145 12.22539  14.71536  1.000 26.73062 ? 172 VAL A CG2   1 ? 
ATOM   1357 N  N     . LYS A 1 177 ? 18.69099 10.53228  10.89754  1.000 24.71634 ? 173 LYS A N     1 ? 
ATOM   1358 C  CA    . LYS A 1 177 ? 19.76145 10.48974  9.91176   1.000 27.95242 ? 173 LYS A CA    1 ? 
ATOM   1359 C  C     . LYS A 1 177 ? 19.13779 10.35637  8.53181   1.000 28.50621 ? 173 LYS A C     1 ? 
ATOM   1360 O  O     . LYS A 1 177 ? 17.97602 9.97552   8.39613   1.000 27.53060 ? 173 LYS A O     1 ? 
ATOM   1361 C  CB    . LYS A 1 177 ? 20.72880 9.32585   10.19078  1.000 30.17140 ? 173 LYS A CB    1 ? 
ATOM   1362 C  CG    . LYS A 1 177 ? 20.06800 7.96801   10.16115  1.000 29.91257 ? 173 LYS A CG    1 ? 
ATOM   1363 C  CD    . LYS A 1 177 ? 20.90589 6.86458   10.83128  1.000 36.40355 ? 173 LYS A CD    1 ? 
ATOM   1364 C  CE    . LYS A 1 177 ? 22.16468 6.54765   10.04133  1.000 39.25702 ? 173 LYS A CE    1 ? 
ATOM   1365 N  NZ    . LYS A 1 177 ? 22.53947 5.10125   10.15573  1.000 44.54645 ? 173 LYS A NZ    1 ? 
ATOM   1366 N  N     . PHE A 1 178 ? 19.90015 10.71693  7.50050   1.000 30.82605 ? 174 PHE A N     1 ? 
ATOM   1367 C  CA    . PHE A 1 178 ? 19.40875 10.48330  6.14852   1.000 30.00457 ? 174 PHE A CA    1 ? 
ATOM   1368 C  C     . PHE A 1 178 ? 19.19620 8.99317   5.93706   1.000 33.03232 ? 174 PHE A C     1 ? 
ATOM   1369 O  O     . PHE A 1 178 ? 20.00144 8.17072   6.38703   1.000 34.45099 ? 174 PHE A O     1 ? 
ATOM   1370 C  CB    . PHE A 1 178 ? 20.38636 11.03898  5.11984   1.000 31.74632 ? 174 PHE A CB    1 ? 
ATOM   1371 C  CG    . PHE A 1 178 ? 20.35690 12.52692  5.02456   1.000 31.61116 ? 174 PHE A CG    1 ? 
ATOM   1372 C  CD1   . PHE A 1 178 ? 19.24760 13.17738  4.49646   1.000 33.31029 ? 174 PHE A CD1   1 ? 
ATOM   1373 C  CD2   . PHE A 1 178 ? 21.42027 13.28405  5.47575   1.000 33.12988 ? 174 PHE A CD2   1 ? 
ATOM   1374 C  CE1   . PHE A 1 178 ? 19.20693 14.55999  4.40902   1.000 31.22261 ? 174 PHE A CE1   1 ? 
ATOM   1375 C  CE2   . PHE A 1 178 ? 21.38882 14.66721  5.38728   1.000 35.82090 ? 174 PHE A CE2   1 ? 
ATOM   1376 C  CZ    . PHE A 1 178 ? 20.27864 15.30434  4.85288   1.000 35.45390 ? 174 PHE A CZ    1 ? 
ATOM   1377 N  N     . ALA A 1 179 ? 18.08901 8.64784   5.27453   1.000 32.26501 ? 175 ALA A N     1 ? 
ATOM   1378 C  CA    . ALA A 1 179 ? 17.71641 7.25201   5.10180   1.000 33.67832 ? 175 ALA A CA    1 ? 
ATOM   1379 C  C     . ALA A 1 179 ? 18.67215 6.56264   4.13789   1.000 37.94781 ? 175 ALA A C     1 ? 
ATOM   1380 O  O     . ALA A 1 179 ? 19.19616 7.18139   3.21010   1.000 36.54497 ? 175 ALA A O     1 ? 
ATOM   1381 C  CB    . ALA A 1 179 ? 16.27604 7.13293   4.59038   1.000 35.96143 ? 175 ALA A CB    1 ? 
ATOM   1382 N  N     . ASP A 1 180 ? 18.88982 5.26496   4.37775   1.000 39.97692 ? 176 ASP A N     1 ? 
ATOM   1383 C  CA    . ASP A 1 180 ? 19.85115 4.42953   3.63910   1.000 44.32014 ? 176 ASP A CA    1 ? 
ATOM   1384 C  C     . ASP A 1 180 ? 19.77990 4.60960   2.12364   1.000 51.15669 ? 176 ASP A C     1 ? 
ATOM   1385 O  O     . ASP A 1 180 ? 18.71472 4.89402   1.57107   1.000 58.92608 ? 176 ASP A O     1 ? 
ATOM   1386 C  CB    . ASP A 1 180 ? 19.63532 2.94548   3.97948   1.000 44.18347 ? 176 ASP A CB    1 ? 
ATOM   1387 C  CG    . ASP A 1 180 ? 20.43798 2.48771   5.20067   1.000 51.62136 ? 176 ASP A CG    1 ? 
ATOM   1388 O  OD1   . ASP A 1 180 ? 21.25384 3.28215   5.72492   1.000 52.02793 ? 176 ASP A OD1   1 ? 
ATOM   1389 O  OD2   . ASP A 1 180 ? 20.25688 1.32488   5.63842   1.000 52.73120 ? 176 ASP A OD2   1 ? 
ATOM   1390 P  P     . DT  B 2 2   ? 12.49457 -6.84657  18.64748  1.000 41.91214 ? 1   DT  B P     1 ? 
ATOM   1391 O  OP1   . DT  B 2 2   ? 11.88287 -5.50992  18.53714  1.000 39.91223 ? 1   DT  B OP1   1 ? 
ATOM   1392 O  OP2   . DT  B 2 2   ? 13.02198 -7.49410  17.43168  1.000 39.16935 ? 1   DT  B OP2   1 ? 
ATOM   1393 O  "O5'" . DT  B 2 2   ? 13.71540 -6.74137  19.66748  1.000 36.08499 ? 1   DT  B "O5'" 1 ? 
ATOM   1394 C  "C5'" . DT  B 2 2   ? 13.69077 -5.79345  20.70838  1.000 35.29334 ? 1   DT  B "C5'" 1 ? 
ATOM   1395 C  "C4'" . DT  B 2 2   ? 15.10147 -5.38381  21.06707  1.000 35.41189 ? 1   DT  B "C4'" 1 ? 
ATOM   1396 O  "O4'" . DT  B 2 2   ? 15.87991 -6.56549  21.40709  1.000 29.36680 ? 1   DT  B "O4'" 1 ? 
ATOM   1397 C  "C3'" . DT  B 2 2   ? 15.87189 -4.70064  19.94320  1.000 35.34756 ? 1   DT  B "C3'" 1 ? 
ATOM   1398 O  "O3'" . DT  B 2 2   ? 16.81821 -3.84767  20.50948  1.000 35.05096 ? 1   DT  B "O3'" 1 ? 
ATOM   1399 C  "C2'" . DT  B 2 2   ? 16.56906 -5.87829  19.27694  1.000 29.76778 ? 1   DT  B "C2'" 1 ? 
ATOM   1400 C  "C1'" . DT  B 2 2   ? 16.95469 -6.70172  20.49909  1.000 32.21121 ? 1   DT  B "C1'" 1 ? 
ATOM   1401 N  N1    . DT  B 2 2   ? 17.16150 -8.14619  20.17974  1.000 27.35795 ? 1   DT  B N1    1 ? 
ATOM   1402 C  C2    . DT  B 2 2   ? 18.40814 -8.69691  20.36278  1.000 25.83876 ? 1   DT  B C2    1 ? 
ATOM   1403 O  O2    . DT  B 2 2   ? 19.35460 -8.07108  20.82659  1.000 28.28009 ? 1   DT  B O2    1 ? 
ATOM   1404 N  N3    . DT  B 2 2   ? 18.51124 -10.02507 20.01452  1.000 28.16485 ? 1   DT  B N3    1 ? 
ATOM   1405 C  C4    . DT  B 2 2   ? 17.51154 -10.82961 19.49305  1.000 28.32558 ? 1   DT  B C4    1 ? 
ATOM   1406 O  O4    . DT  B 2 2   ? 17.69726 -12.01417 19.20008  1.000 26.54910 ? 1   DT  B O4    1 ? 
ATOM   1407 C  C5    . DT  B 2 2   ? 16.22942 -10.18369 19.31408  1.000 28.72874 ? 1   DT  B C5    1 ? 
ATOM   1408 C  C7    . DT  B 2 2   ? 15.07235 -10.96553 18.75708  1.000 30.41445 ? 1   DT  B C7    1 ? 
ATOM   1409 C  C6    . DT  B 2 2   ? 16.11793 -8.88418  19.65314  1.000 29.38150 ? 1   DT  B C6    1 ? 
ATOM   1410 P  P     . DG  B 2 3   ? 16.65240 -2.25088  20.46792  1.000 33.98467 ? 2   DG  B P     1 ? 
ATOM   1411 O  OP1   . DG  B 2 3   ? 17.49767 -1.80734  21.59578  1.000 33.94497 ? 2   DG  B OP1   1 ? 
ATOM   1412 O  OP2   . DG  B 2 3   ? 15.23352 -1.86768  20.33619  1.000 33.65765 ? 2   DG  B OP2   1 ? 
ATOM   1413 O  "O5'" . DG  B 2 3   ? 17.45537 -1.81137  19.17351  1.000 32.47416 ? 2   DG  B "O5'" 1 ? 
ATOM   1414 C  "C5'" . DG  B 2 3   ? 16.87604 -1.90236  17.88909  1.000 30.15735 ? 2   DG  B "C5'" 1 ? 
ATOM   1415 C  "C4'" . DG  B 2 3   ? 17.96894 -1.91320  16.84856  1.000 31.48280 ? 2   DG  B "C4'" 1 ? 
ATOM   1416 O  "O4'" . DG  B 2 3   ? 18.69547 -0.65556  16.89449  1.000 31.74363 ? 2   DG  B "O4'" 1 ? 
ATOM   1417 C  "C3'" . DG  B 2 3   ? 19.01722 -3.00454  17.04144  1.000 25.15461 ? 2   DG  B "C3'" 1 ? 
ATOM   1418 O  "O3'" . DG  B 2 3   ? 19.40044 -3.51443  15.77911  1.000 29.44629 ? 2   DG  B "O3'" 1 ? 
ATOM   1419 C  "C2'" . DG  B 2 3   ? 20.17720 -2.26367  17.73595  1.000 29.76790 ? 2   DG  B "C2'" 1 ? 
ATOM   1420 C  "C1'" . DG  B 2 3   ? 20.08887 -0.87978  17.11119  1.000 28.72610 ? 2   DG  B "C1'" 1 ? 
ATOM   1421 N  N9    . DG  B 2 3   ? 20.55356 0.21297   17.97665  1.000 30.66968 ? 2   DG  B N9    1 ? 
ATOM   1422 C  C8    . DG  B 2 3   ? 20.55879 0.22900   19.35058  1.000 30.68352 ? 2   DG  B C8    1 ? 
ATOM   1423 N  N7    . DG  B 2 3   ? 20.94886 1.36507   19.85540  1.000 32.83449 ? 2   DG  B N7    1 ? 
ATOM   1424 C  C5    . DG  B 2 3   ? 21.20457 2.16976   18.74810  1.000 31.67670 ? 2   DG  B C5    1 ? 
ATOM   1425 C  C6    . DG  B 2 3   ? 21.65612 3.51189   18.67517  1.000 31.48028 ? 2   DG  B C6    1 ? 
ATOM   1426 O  O6    . DG  B 2 3   ? 21.92118 4.29395   19.60875  1.000 29.46769 ? 2   DG  B O6    1 ? 
ATOM   1427 N  N1    . DG  B 2 3   ? 21.76944 3.94890   17.35761  1.000 29.19929 ? 2   DG  B N1    1 ? 
ATOM   1428 C  C2    . DG  B 2 3   ? 21.50466 3.19274   16.25344  1.000 33.06938 ? 2   DG  B C2    1 ? 
ATOM   1429 N  N2    . DG  B 2 3   ? 21.68691 3.79879   15.06806  1.000 30.84214 ? 2   DG  B N2    1 ? 
ATOM   1430 N  N3    . DG  B 2 3   ? 21.07980 1.92893   16.30154  1.000 29.57542 ? 2   DG  B N3    1 ? 
ATOM   1431 C  C4    . DG  B 2 3   ? 20.94821 1.48482   17.58170  1.000 31.16183 ? 2   DG  B C4    1 ? 
ATOM   1432 P  P     . DG  B 2 4   ? 18.70130 -4.83714  15.20152  1.000 31.69165 ? 3   DG  B P     1 ? 
ATOM   1433 O  OP1   . DG  B 2 4   ? 18.36892 -5.71711  16.34929  1.000 31.12731 ? 3   DG  B OP1   1 ? 
ATOM   1434 O  OP2   . DG  B 2 4   ? 19.56152 -5.35218  14.10573  1.000 32.08459 ? 3   DG  B OP2   1 ? 
ATOM   1435 O  "O5'" . DG  B 2 4   ? 17.32433 -4.31136  14.60696  1.000 31.76419 ? 3   DG  B "O5'" 1 ? 
ATOM   1436 C  "C5'" . DG  B 2 4   ? 17.31437 -3.55217  13.42393  1.000 32.76801 ? 3   DG  B "C5'" 1 ? 
ATOM   1437 C  "C4'" . DG  B 2 4   ? 15.90154 -3.11896  13.10006  1.000 32.37475 ? 3   DG  B "C4'" 1 ? 
ATOM   1438 O  "O4'" . DG  B 2 4   ? 15.35134 -2.39907  14.23345  1.000 29.08843 ? 3   DG  B "O4'" 1 ? 
ATOM   1439 C  "C3'" . DG  B 2 4   ? 15.79475 -2.18466  11.91212  1.000 35.50301 ? 3   DG  B "C3'" 1 ? 
ATOM   1440 O  "O3'" . DG  B 2 4   ? 15.54830 -2.94635  10.73450  1.000 35.89937 ? 3   DG  B "O3'" 1 ? 
ATOM   1441 C  "C2'" . DG  B 2 4   ? 14.59933 -1.29896  12.26458  1.000 33.95356 ? 3   DG  B "C2'" 1 ? 
ATOM   1442 C  "C1'" . DG  B 2 4   ? 14.57355 -1.31227  13.79517  1.000 31.33790 ? 3   DG  B "C1'" 1 ? 
ATOM   1443 N  N9    . DG  B 2 4   ? 15.09316 -0.08467  14.40902  1.000 28.64014 ? 3   DG  B N9    1 ? 
ATOM   1444 C  C8    . DG  B 2 4   ? 14.37221 0.84350   15.11288  1.000 27.81820 ? 3   DG  B C8    1 ? 
ATOM   1445 N  N7    . DG  B 2 4   ? 15.09071 1.84391   15.55178  1.000 28.15133 ? 3   DG  B N7    1 ? 
ATOM   1446 C  C5    . DG  B 2 4   ? 16.37504 1.54949   15.10539  1.000 30.57006 ? 3   DG  B C5    1 ? 
ATOM   1447 C  C6    . DG  B 2 4   ? 17.58413 2.25449   15.28464  1.000 29.27208 ? 3   DG  B C6    1 ? 
ATOM   1448 O  O6    . DG  B 2 4   ? 17.75842 3.31855   15.87576  1.000 27.53368 ? 3   DG  B O6    1 ? 
ATOM   1449 N  N1    . DG  B 2 4   ? 18.66251 1.60465   14.67810  1.000 31.16335 ? 3   DG  B N1    1 ? 
ATOM   1450 C  C2    . DG  B 2 4   ? 18.57436 0.41693   13.99746  1.000 31.58133 ? 3   DG  B C2    1 ? 
ATOM   1451 N  N2    . DG  B 2 4   ? 19.71615 -0.06671  13.48686  1.000 29.80102 ? 3   DG  B N2    1 ? 
ATOM   1452 N  N3    . DG  B 2 4   ? 17.44443 -0.25102  13.82470  1.000 30.49338 ? 3   DG  B N3    1 ? 
ATOM   1453 C  C4    . DG  B 2 4   ? 16.39261 0.36065   14.40934  1.000 29.61411 ? 3   DG  B C4    1 ? 
ATOM   1454 P  P     . DT  B 2 5   ? 16.37618 -2.66773  9.38216   1.000 39.84202 ? 4   DT  B P     1 ? 
ATOM   1455 O  OP1   . DT  B 2 5   ? 15.87094 -3.65237  8.39407   1.000 43.62589 ? 4   DT  B OP1   1 ? 
ATOM   1456 O  OP2   . DT  B 2 5   ? 17.82893 -2.58032  9.67270   1.000 40.89776 ? 4   DT  B OP2   1 ? 
ATOM   1457 O  "O5'" . DT  B 2 5   ? 15.92615 -1.19921  8.94659   1.000 39.27124 ? 4   DT  B "O5'" 1 ? 
ATOM   1458 C  "C5'" . DT  B 2 5   ? 14.57152 -0.90265  8.67409   1.000 40.29193 ? 4   DT  B "C5'" 1 ? 
ATOM   1459 C  "C4'" . DT  B 2 5   ? 14.45935 -0.07688  7.40719   1.000 41.37626 ? 4   DT  B "C4'" 1 ? 
ATOM   1460 O  "O4'" . DT  B 2 5   ? 15.03553 1.23937   7.62619   1.000 40.56222 ? 4   DT  B "O4'" 1 ? 
ATOM   1461 C  "C3'" . DT  B 2 5   ? 15.18407 -0.65397  6.19942   1.000 46.85821 ? 4   DT  B "C3'" 1 ? 
ATOM   1462 O  "O3'" . DT  B 2 5   ? 14.44043 -0.38946  5.02505   1.000 58.57714 ? 4   DT  B "O3'" 1 ? 
ATOM   1463 C  "C2'" . DT  B 2 5   ? 16.51180 0.09755   6.19071   1.000 44.32306 ? 4   DT  B "C2'" 1 ? 
ATOM   1464 C  "C1'" . DT  B 2 5   ? 16.11856 1.46135   6.74610   1.000 40.68491 ? 4   DT  B "C1'" 1 ? 
ATOM   1465 N  N1    . DT  B 2 5   ? 17.21427 2.07942   7.52754   1.000 37.96754 ? 4   DT  B N1    1 ? 
ATOM   1466 C  C2    . DT  B 2 5   ? 17.76625 3.27800   7.12192   1.000 39.48557 ? 4   DT  B C2    1 ? 
ATOM   1467 O  O2    . DT  B 2 5   ? 17.39484 3.88996   6.13607   1.000 39.24658 ? 4   DT  B O2    1 ? 
ATOM   1468 N  N3    . DT  B 2 5   ? 18.78557 3.73486   7.92325   1.000 39.20097 ? 4   DT  B N3    1 ? 
ATOM   1469 C  C4    . DT  B 2 5   ? 19.28506 3.12199   9.06252   1.000 39.25879 ? 4   DT  B C4    1 ? 
ATOM   1470 O  O4    . DT  B 2 5   ? 20.20343 3.60404   9.71925   1.000 41.52077 ? 4   DT  B O4    1 ? 
ATOM   1471 C  C5    . DT  B 2 5   ? 18.65551 1.87468   9.42219   1.000 38.82343 ? 4   DT  B C5    1 ? 
ATOM   1472 C  C7    . DT  B 2 5   ? 19.10736 1.11743   10.63325  1.000 37.02660 ? 4   DT  B C7    1 ? 
ATOM   1473 C  C6    . DT  B 2 5   ? 17.66736 1.42204   8.64615   1.000 39.54294 ? 4   DT  B C6    1 ? 
ATOM   1474 P  P     . DC  B 2 6   ? 14.23381 -1.53611  3.91783   1.000 61.57161 ? 5   DC  B P     1 ? 
ATOM   1475 O  OP1   . DC  B 2 6   ? 14.40662 -2.85391  4.57351   1.000 55.70496 ? 5   DC  B OP1   1 ? 
ATOM   1476 O  OP2   . DC  B 2 6   ? 15.10123 -1.18966  2.76669   1.000 59.60293 ? 5   DC  B OP2   1 ? 
ATOM   1477 O  "O5'" . DC  B 2 6   ? 12.70135 -1.35035  3.48985   1.000 65.37122 ? 5   DC  B "O5'" 1 ? 
ATOM   1478 C  "C5'" . DC  B 2 6   ? 11.72809 -0.91842  4.45868   1.000 65.25455 ? 5   DC  B "C5'" 1 ? 
ATOM   1479 C  "C4'" . DC  B 2 6   ? 10.55266 -0.19453  3.79757   1.000 70.32343 ? 5   DC  B "C4'" 1 ? 
ATOM   1480 O  "O4'" . DC  B 2 6   ? 10.83990 1.22392   3.69390   1.000 73.06245 ? 5   DC  B "O4'" 1 ? 
ATOM   1481 C  "C3'" . DC  B 2 6   ? 10.22031 -0.63268  2.38410   1.000 74.46037 ? 5   DC  B "C3'" 1 ? 
ATOM   1482 O  "O3'" . DC  B 2 6   ? 8.84879  -0.38214  2.10146   1.000 80.36365 ? 5   DC  B "O3'" 1 ? 
ATOM   1483 C  "C2'" . DC  B 2 6   ? 11.12159 0.26763   1.55723   1.000 75.55562 ? 5   DC  B "C2'" 1 ? 
ATOM   1484 C  "C1'" . DC  B 2 6   ? 11.12332 1.56723   2.34717   1.000 73.59150 ? 5   DC  B "C1'" 1 ? 
ATOM   1485 N  N1    . DC  B 2 6   ? 12.45097 2.26711   2.29814   1.000 74.10398 ? 5   DC  B N1    1 ? 
ATOM   1486 C  C2    . DC  B 2 6   ? 12.50697 3.66620   2.21943   1.000 72.42398 ? 5   DC  B C2    1 ? 
ATOM   1487 O  O2    . DC  B 2 6   ? 11.44858 4.31504   2.20139   1.000 67.92398 ? 5   DC  B O2    1 ? 
ATOM   1488 N  N3    . DC  B 2 6   ? 13.72700 4.27335   2.17426   1.000 67.31398 ? 5   DC  B N3    1 ? 
ATOM   1489 C  C4    . DC  B 2 6   ? 14.84458 3.53659   2.19913   1.000 71.09398 ? 5   DC  B C4    1 ? 
ATOM   1490 N  N4    . DC  B 2 6   ? 16.02084 4.17502   2.15276   1.000 65.39398 ? 5   DC  B N4    1 ? 
ATOM   1491 C  C5    . DC  B 2 6   ? 14.80400 2.11220   2.27233   1.000 73.82398 ? 5   DC  B C5    1 ? 
ATOM   1492 C  C6    . DC  B 2 6   ? 13.60057 1.52675   2.31500   1.000 76.79398 ? 5   DC  B C6    1 ? 
HETATM 1493 MG MG    . MG  C 3 .   ? 14.29028 -7.05720  15.64519  1.000 40.95815 ? 101 MG  B MG    1 ? 
HETATM 1494 O  O     . HOH D 4 .   ? 29.34725 -2.55011  -36.14324 1.000 37.80175 ? 201 HOH A O     1 ? 
HETATM 1495 O  O     . HOH D 4 .   ? 21.20096 16.87269  -11.39798 1.000 43.06898 ? 202 HOH A O     1 ? 
HETATM 1496 O  O     . HOH D 4 .   ? 14.48218 22.09011  -23.86923 1.000 31.00925 ? 203 HOH A O     1 ? 
HETATM 1497 O  O     . HOH D 4 .   ? 21.78462 19.12434  -17.17449 1.000 43.24986 ? 204 HOH A O     1 ? 
HETATM 1498 O  O     . HOH D 4 .   ? 14.08967 24.57306  2.44493   1.000 40.74658 ? 205 HOH A O     1 ? 
HETATM 1499 O  O     . HOH D 4 .   ? 16.397   7.546     -16.350   1.000 33.25740 ? 206 HOH A O     1 ? 
HETATM 1500 O  O     . HOH D 4 .   ? 19.97975 9.29229   -16.89172 1.000 30.13962 ? 207 HOH A O     1 ? 
HETATM 1501 O  O     . HOH D 4 .   ? 14.47454 25.33156  -22.48544 1.000 33.82776 ? 208 HOH A O     1 ? 
HETATM 1502 O  O     . HOH D 4 .   ? 2.92869  5.44270   -33.51133 1.000 36.91615 ? 209 HOH A O     1 ? 
HETATM 1503 O  O     . HOH D 4 .   ? 14.161   9.357     -15.439   1.000 37.71194 ? 210 HOH A O     1 ? 
HETATM 1504 O  O     . HOH D 4 .   ? 23.04158 18.99827  -24.73218 1.000 40.36778 ? 211 HOH A O     1 ? 
HETATM 1505 O  O     . HOH D 4 .   ? 17.26669 27.88814  -33.41315 1.000 40.22327 ? 212 HOH A O     1 ? 
HETATM 1506 O  O     . HOH D 4 .   ? 26.34206 16.24213  -30.51680 1.000 39.06946 ? 213 HOH A O     1 ? 
HETATM 1507 O  O     . HOH D 4 .   ? 13.00115 7.42864   -40.65725 1.000 50.57085 ? 214 HOH A O     1 ? 
HETATM 1508 O  O     . HOH D 4 .   ? 18.77005 20.93426  -40.12749 1.000 40.07822 ? 215 HOH A O     1 ? 
HETATM 1509 O  O     . HOH D 4 .   ? 12.80767 28.72168  -33.89413 1.000 35.68602 ? 216 HOH A O     1 ? 
HETATM 1510 O  O     . HOH D 4 .   ? 20.47047 5.64295   6.89777   1.000 40.53745 ? 217 HOH A O     1 ? 
HETATM 1511 O  O     . HOH D 4 .   ? 11.434   -1.554    26.003    1.000 42.86521 ? 218 HOH A O     1 ? 
HETATM 1512 O  O     . HOH D 4 .   ? 19.18038 9.38264   -33.87731 1.000 25.23901 ? 219 HOH A O     1 ? 
HETATM 1513 O  O     . HOH D 4 .   ? 15.22837 19.58459  19.53054  1.000 44.37004 ? 220 HOH A O     1 ? 
HETATM 1514 O  O     . HOH D 4 .   ? 2.05111  2.43825   10.07924  1.000 47.14688 ? 221 HOH A O     1 ? 
HETATM 1515 O  O     . HOH D 4 .   ? 20.71010 19.88081  -25.21395 1.000 28.57757 ? 222 HOH A O     1 ? 
HETATM 1516 O  O     . HOH D 4 .   ? 17.22499 0.19548   -34.59293 1.000 31.82074 ? 223 HOH A O     1 ? 
HETATM 1517 O  O     . HOH D 4 .   ? 1.69120  15.44941  -24.90246 1.000 33.30790 ? 224 HOH A O     1 ? 
HETATM 1518 O  O     . HOH D 4 .   ? 14.42974 7.16691   21.88488  1.000 24.33889 ? 225 HOH A O     1 ? 
HETATM 1519 O  O     . HOH D 4 .   ? 1.57139  9.33175   -33.68515 1.000 37.38566 ? 226 HOH A O     1 ? 
HETATM 1520 O  O     . HOH D 4 .   ? 19.33074 15.23021  -5.12797  1.000 44.93783 ? 227 HOH A O     1 ? 
HETATM 1521 O  O     . HOH D 4 .   ? 16.78840 16.40278  -1.91866  1.000 39.16179 ? 228 HOH A O     1 ? 
HETATM 1522 O  O     . HOH D 4 .   ? 18.24293 10.74721  26.60120  1.000 24.17231 ? 229 HOH A O     1 ? 
HETATM 1523 O  O     . HOH D 4 .   ? 21.54942 22.27820  -21.87082 1.000 43.83155 ? 230 HOH A O     1 ? 
HETATM 1524 O  O     . HOH D 4 .   ? 16.78599 20.68934  -1.56680  1.000 42.91831 ? 231 HOH A O     1 ? 
HETATM 1525 O  O     . HOH D 4 .   ? 5.99999  3.36601   16.59692  1.000 38.98210 ? 232 HOH A O     1 ? 
HETATM 1526 O  O     . HOH D 4 .   ? 13.35522 16.30272  20.92138  1.000 41.26637 ? 233 HOH A O     1 ? 
HETATM 1527 O  O     . HOH D 4 .   ? 22.98481 8.61811   -39.61837 1.000 46.04272 ? 234 HOH A O     1 ? 
HETATM 1528 O  O     . HOH D 4 .   ? 8.15682  20.19415  -36.19815 1.000 32.55041 ? 235 HOH A O     1 ? 
HETATM 1529 O  O     . HOH D 4 .   ? 18.62375 22.71291  13.26504  1.000 39.56459 ? 236 HOH A O     1 ? 
HETATM 1530 O  O     . HOH D 4 .   ? 10.17688 18.82973  18.05417  1.000 38.78126 ? 237 HOH A O     1 ? 
HETATM 1531 O  O     . HOH D 4 .   ? 23.21824 10.15255  -35.68792 1.000 32.92390 ? 238 HOH A O     1 ? 
HETATM 1532 O  O     . HOH D 4 .   ? 13.08200 16.52222  -39.30979 1.000 30.86095 ? 239 HOH A O     1 ? 
HETATM 1533 O  O     . HOH D 4 .   ? 4.82627  20.01498  -21.07292 1.000 40.62925 ? 240 HOH A O     1 ? 
HETATM 1534 O  O     . HOH D 4 .   ? 8.76973  9.21733   4.23885   1.000 42.88099 ? 241 HOH A O     1 ? 
HETATM 1535 O  O     . HOH D 4 .   ? 20.18244 23.29180  6.59892   1.000 47.59946 ? 242 HOH A O     1 ? 
HETATM 1536 O  O     . HOH D 4 .   ? 26.21662 14.13515  -29.05121 1.000 34.72048 ? 243 HOH A O     1 ? 
HETATM 1537 O  O     . HOH D 4 .   ? 20.36309 17.09523  18.45906  1.000 32.43744 ? 244 HOH A O     1 ? 
HETATM 1538 O  O     . HOH D 4 .   ? 22.58410 11.57972  11.98336  1.000 33.63097 ? 245 HOH A O     1 ? 
HETATM 1539 O  O     . HOH D 4 .   ? 6.13540  18.67989  -35.27443 1.000 39.03320 ? 246 HOH A O     1 ? 
HETATM 1540 O  O     . HOH D 4 .   ? 23.12513 5.73443   -35.96207 1.000 32.23922 ? 247 HOH A O     1 ? 
HETATM 1541 O  O     . HOH D 4 .   ? 8.99406  1.78321   22.79840  1.000 41.36765 ? 248 HOH A O     1 ? 
HETATM 1542 O  O     . HOH D 4 .   ? 18.07545 20.40062  19.97365  1.000 49.22789 ? 249 HOH A O     1 ? 
HETATM 1543 O  O     . HOH D 4 .   ? 8.60395  8.53231   -33.04351 1.000 28.38942 ? 250 HOH A O     1 ? 
HETATM 1544 O  O     . HOH D 4 .   ? 13.34357 28.93486  -27.10325 1.000 33.75456 ? 251 HOH A O     1 ? 
HETATM 1545 O  O     . HOH D 4 .   ? 8.24217  29.17098  -28.39825 1.000 35.38628 ? 252 HOH A O     1 ? 
HETATM 1546 O  O     . HOH D 4 .   ? 8.52339  -5.07737  15.64819  1.000 44.47799 ? 253 HOH A O     1 ? 
HETATM 1547 O  O     . HOH D 4 .   ? 20.65734 13.59969  -11.80195 1.000 41.45598 ? 254 HOH A O     1 ? 
HETATM 1548 O  O     . HOH D 4 .   ? 25.00891 19.63093  -32.08025 1.000 36.58906 ? 255 HOH A O     1 ? 
HETATM 1549 O  O     . HOH D 4 .   ? 22.95369 15.01792  19.55346  1.000 34.09664 ? 256 HOH A O     1 ? 
HETATM 1550 O  O     . HOH D 4 .   ? 3.09125  17.25678  -32.81932 1.000 35.11241 ? 257 HOH A O     1 ? 
HETATM 1551 O  O     . HOH D 4 .   ? 34.87986 3.99300   -34.14372 1.000 37.64694 ? 258 HOH A O     1 ? 
HETATM 1552 O  O     . HOH D 4 .   ? 7.98322  8.80918   24.69897  1.000 35.81482 ? 259 HOH A O     1 ? 
HETATM 1553 O  O     . HOH D 4 .   ? 17.62782 22.33007  0.35739   1.000 42.20142 ? 260 HOH A O     1 ? 
HETATM 1554 O  O     . HOH D 4 .   ? 16.35896 -1.31183  -31.62856 1.000 26.08563 ? 261 HOH A O     1 ? 
HETATM 1555 O  O     . HOH D 4 .   ? 3.02113  17.29489  8.67844   1.000 50.91938 ? 262 HOH A O     1 ? 
HETATM 1556 O  O     . HOH D 4 .   ? 22.89072 8.18692   6.56884   1.000 44.37823 ? 263 HOH A O     1 ? 
HETATM 1557 O  O     . HOH D 4 .   ? 20.43324 13.41945  -18.33779 1.000 31.39036 ? 264 HOH A O     1 ? 
HETATM 1558 O  O     . HOH D 4 .   ? 2.49514  11.36425  -35.91153 1.000 33.69731 ? 265 HOH A O     1 ? 
HETATM 1559 O  O     . HOH D 4 .   ? 22.59432 11.46081  8.35395   1.000 35.84453 ? 266 HOH A O     1 ? 
HETATM 1560 O  O     . HOH D 4 .   ? 22.78724 1.38086   -27.94740 1.000 36.41439 ? 267 HOH A O     1 ? 
HETATM 1561 O  O     . HOH D 4 .   ? 28.39912 13.09631  -30.28341 1.000 35.48822 ? 268 HOH A O     1 ? 
HETATM 1562 O  O     . HOH D 4 .   ? 25.59328 17.01472  2.64607   1.000 39.13520 ? 269 HOH A O     1 ? 
HETATM 1563 O  O     . HOH D 4 .   ? 11.10014 22.50879  -40.12884 1.000 37.23466 ? 270 HOH A O     1 ? 
HETATM 1564 O  O     . HOH D 4 .   ? 14.32457 12.32539  26.87066  1.000 29.03882 ? 271 HOH A O     1 ? 
HETATM 1565 O  O     . HOH D 4 .   ? 14.13687 16.96424  23.66812  1.000 43.67010 ? 272 HOH A O     1 ? 
HETATM 1566 O  O     . HOH D 4 .   ? 22.66209 2.19250   8.20492   1.000 52.48368 ? 273 HOH A O     1 ? 
HETATM 1567 O  O     . HOH D 4 .   ? 9.783    2.016     -32.739   1.000 34.23954 ? 274 HOH A O     1 ? 
HETATM 1568 O  O     . HOH D 4 .   ? 23.44418 22.06000  -31.28948 1.000 36.88688 ? 275 HOH A O     1 ? 
HETATM 1569 O  O     . HOH D 4 .   ? 25.62029 18.15372  -20.91967 1.000 43.47375 ? 276 HOH A O     1 ? 
HETATM 1570 O  O     . HOH D 4 .   ? 13.63712 9.49881   -41.96743 1.000 52.49942 ? 277 HOH A O     1 ? 
HETATM 1571 O  O     . HOH D 4 .   ? 16.519   4.223     -37.912   1.000 38.75410 ? 278 HOH A O     1 ? 
HETATM 1572 O  O     . HOH D 4 .   ? 14.49052 18.60127  -10.10389 1.000 55.92916 ? 279 HOH A O     1 ? 
HETATM 1573 O  O     . HOH D 4 .   ? 1.56248  23.82668  -24.70652 1.000 49.13028 ? 280 HOH A O     1 ? 
HETATM 1574 O  O     . HOH D 4 .   ? -1.693   10.824    -26.335   1.000 44.81570 ? 281 HOH A O     1 ? 
HETATM 1575 O  O     . HOH D 4 .   ? 7.05700  7.80698   -20.65583 1.000 54.19488 ? 282 HOH A O     1 ? 
HETATM 1576 O  O     . HOH D 4 .   ? 14.09730 -1.80483  24.40978  1.000 39.31756 ? 283 HOH A O     1 ? 
HETATM 1577 O  O     . HOH D 4 .   ? 19.36373 12.82633  25.23552  1.000 37.28154 ? 284 HOH A O     1 ? 
HETATM 1578 O  O     . HOH D 4 .   ? 11.66553 0.30063   21.60127  1.000 42.42520 ? 285 HOH A O     1 ? 
HETATM 1579 O  O     . HOH D 4 .   ? 23.75269 8.95520   13.01866  1.000 39.00672 ? 286 HOH A O     1 ? 
HETATM 1580 O  O     . HOH D 4 .   ? 19.08382 19.78834  -2.71018  1.000 44.57851 ? 287 HOH A O     1 ? 
HETATM 1581 O  O     . HOH D 4 .   ? 19.94657 22.79789  0.62052   1.000 50.09263 ? 288 HOH A O     1 ? 
HETATM 1582 O  O     . HOH D 4 .   ? 8.773    1.348     -27.127   1.000 57.30398 ? 289 HOH A O     1 ? 
HETATM 1583 O  O     . HOH D 4 .   ? 4.94266  9.45328   20.79007  1.000 53.69512 ? 290 HOH A O     1 ? 
HETATM 1584 O  O     . HOH D 4 .   ? 16.183   11.198    28.488    1.000 30.75493 ? 291 HOH A O     1 ? 
HETATM 1585 O  O     . HOH D 4 .   ? 9.49332  8.49382   -20.88319 1.000 47.79451 ? 292 HOH A O     1 ? 
HETATM 1586 O  O     . HOH D 4 .   ? 9.16133  33.01957  -25.30275 1.000 41.22934 ? 293 HOH A O     1 ? 
HETATM 1587 O  O     . HOH D 4 .   ? 14.39379 21.73723  18.96865  1.000 51.68383 ? 294 HOH A O     1 ? 
HETATM 1588 O  O     . HOH D 4 .   ? 12.64656 16.74869  -10.65165 1.000 52.37414 ? 295 HOH A O     1 ? 
HETATM 1589 O  O     . HOH E 4 .   ? 20.07305 -6.68034  18.00234  1.000 27.68390 ? 201 HOH B O     1 ? 
HETATM 1590 O  O     . HOH E 4 .   ? 19.99846 -2.27281  11.39541  1.000 37.78579 ? 202 HOH B O     1 ? 
HETATM 1591 O  O     . HOH E 4 .   ? 20.13562 -2.66885  21.25442  1.000 41.28699 ? 203 HOH B O     1 ? 
HETATM 1592 O  O     . HOH E 4 .   ? 21.60633 2.50366   12.53029  1.000 40.22138 ? 204 HOH B O     1 ? 
HETATM 1593 O  O     . HOH E 4 .   ? 22.663   6.650     17.142    1.000 32.44842 ? 205 HOH B O     1 ? 
HETATM 1594 O  O     . HOH E 4 .   ? 12.45652 -6.97605  14.67008  1.000 38.31366 ? 206 HOH B O     1 ? 
HETATM 1595 O  O     . HOH E 4 .   ? 24.590   5.083     20.316    1.000 36.45631 ? 207 HOH B O     1 ? 
HETATM 1596 O  O     . HOH E 4 .   ? 14.54610 -0.07265  22.50114  1.000 36.12847 ? 208 HOH B O     1 ? 
HETATM 1597 O  O     . HOH E 4 .   ? 14.74358 -5.05372  15.79877  1.000 36.44423 ? 209 HOH B O     1 ? 
HETATM 1598 O  O     . HOH E 4 .   ? 19.87611 -1.46544  7.65638   1.000 45.86864 ? 210 HOH B O     1 ? 
HETATM 1599 O  O     . HOH E 4 .   ? 15.40945 -7.14250  13.56778  1.000 37.95065 ? 211 HOH B O     1 ? 
HETATM 1600 O  O     . HOH E 4 .   ? 11.391   -8.109    22.382    1.000 40.30589 ? 212 HOH B O     1 ? 
# 
