data_8UHT
# 
_entry.id   8UHT 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8UHT         pdb_00008uht 10.2210/pdb8uht/pdb 
WWPDB D_1000277408 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-19 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8UHT 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hunter@salk.edu 
_pdbx_contact_author.name_first         Tony 
_pdbx_contact_author.name_last          Hunter 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7691-6993 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kalagiri, R.'    1 0000-0002-4817-3563 
'Stanfield, R.L.' 2 0000-0001-9521-9184 
'Hunter, T.'      3 0000-0002-7691-6993 
'Wilson, I.A.'    4 0000-0002-6469-2419 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.11.04.621849 
_citation.pdbx_database_id_PubMed   39574610 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Martyn, G.D.'     1  ?                   
primary 'Kalagiri, R.'     2  ?                   
primary 'Veggiani, G.'     3  ?                   
primary 'Stanfield, R.L.'  4  ?                   
primary 'Choudhuri, I.'    5  ?                   
primary 'Sala, M.'         6  ?                   
primary 'Meisenhelder, J.' 7  ?                   
primary 'Chen, C.'         8  ?                   
primary 'Biswas, A.'       9  ?                   
primary 'Levy, R.M.'       10 ?                   
primary 'Lyumkis, D.'      11 ?                   
primary 'Wilson, I.A.'     12 ?                   
primary 'Hunter, T.'       13 0000-0002-7691-6993 
primary 'Sidhu, S.S.'      14 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'hSC44.ck.20.elbow Fab heavy chain' 23666.617 1  ? ? ? 'Fab heavy chain' 
2 polymer man 'hSC44.ck.20.elbow Fab light chain' 23879.383 1  ? ? ? 'Fab light chain' 
3 water   nat water                               18.015    10 ? ? ? ?                 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;EVQLVESGGGLVQPGGSLRLSCTASGFSIDSYGFSWVRQAPGKGLEHIGYLTAGGRAFYASWAKSRSTITRNTNENTVTL
KMNSLRAEDTAVYYCAKLGTGSRFAIWGQGTLVTVFNQIKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSG
ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT
;
;EVQLVESGGGLVQPGGSLRLSCTASGFSIDSYGFSWVRQAPGKGLEHIGYLTAGGRAFYASWAKSRSTITRNTNENTVTL
KMNSLRAEDTAVYYCAKLGTGSRFAIWGQGTLVTVFNQIKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSG
ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT
;
H ? 
2 'polypeptide(L)' no no 
;DIQMTQSPSSLSASVGDRVTITCRASQSVWRNKNVAWYQQKPGKAPKRLIYAIASLYSGVPSRFSGSGSGTDFTLTISSL
QPEDFATYYCVGHYGSENDAYYAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVSWYVDNAL
QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
;
;DIQMTQSPSSLSASVGDRVTITCRASQSVWRNKNVAWYQQKPGKAPKRLIYAIASLYSGVPSRFSGSGSGTDFTLTISSL
QPEDFATYYCVGHYGSENDAYYAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVSWYVDNAL
QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
;
L ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLU n 
1 2   VAL n 
1 3   GLN n 
1 4   LEU n 
1 5   VAL n 
1 6   GLU n 
1 7   SER n 
1 8   GLY n 
1 9   GLY n 
1 10  GLY n 
1 11  LEU n 
1 12  VAL n 
1 13  GLN n 
1 14  PRO n 
1 15  GLY n 
1 16  GLY n 
1 17  SER n 
1 18  LEU n 
1 19  ARG n 
1 20  LEU n 
1 21  SER n 
1 22  CYS n 
1 23  THR n 
1 24  ALA n 
1 25  SER n 
1 26  GLY n 
1 27  PHE n 
1 28  SER n 
1 29  ILE n 
1 30  ASP n 
1 31  SER n 
1 32  TYR n 
1 33  GLY n 
1 34  PHE n 
1 35  SER n 
1 36  TRP n 
1 37  VAL n 
1 38  ARG n 
1 39  GLN n 
1 40  ALA n 
1 41  PRO n 
1 42  GLY n 
1 43  LYS n 
1 44  GLY n 
1 45  LEU n 
1 46  GLU n 
1 47  HIS n 
1 48  ILE n 
1 49  GLY n 
1 50  TYR n 
1 51  LEU n 
1 52  THR n 
1 53  ALA n 
1 54  GLY n 
1 55  GLY n 
1 56  ARG n 
1 57  ALA n 
1 58  PHE n 
1 59  TYR n 
1 60  ALA n 
1 61  SER n 
1 62  TRP n 
1 63  ALA n 
1 64  LYS n 
1 65  SER n 
1 66  ARG n 
1 67  SER n 
1 68  THR n 
1 69  ILE n 
1 70  THR n 
1 71  ARG n 
1 72  ASN n 
1 73  THR n 
1 74  ASN n 
1 75  GLU n 
1 76  ASN n 
1 77  THR n 
1 78  VAL n 
1 79  THR n 
1 80  LEU n 
1 81  LYS n 
1 82  MET n 
1 83  ASN n 
1 84  SER n 
1 85  LEU n 
1 86  ARG n 
1 87  ALA n 
1 88  GLU n 
1 89  ASP n 
1 90  THR n 
1 91  ALA n 
1 92  VAL n 
1 93  TYR n 
1 94  TYR n 
1 95  CYS n 
1 96  ALA n 
1 97  LYS n 
1 98  LEU n 
1 99  GLY n 
1 100 THR n 
1 101 GLY n 
1 102 SER n 
1 103 ARG n 
1 104 PHE n 
1 105 ALA n 
1 106 ILE n 
1 107 TRP n 
1 108 GLY n 
1 109 GLN n 
1 110 GLY n 
1 111 THR n 
1 112 LEU n 
1 113 VAL n 
1 114 THR n 
1 115 VAL n 
1 116 PHE n 
1 117 ASN n 
1 118 GLN n 
1 119 ILE n 
1 120 LYS n 
1 121 GLY n 
1 122 PRO n 
1 123 SER n 
1 124 VAL n 
1 125 PHE n 
1 126 PRO n 
1 127 LEU n 
1 128 ALA n 
1 129 PRO n 
1 130 SER n 
1 131 SER n 
1 132 LYS n 
1 133 SER n 
1 134 THR n 
1 135 SER n 
1 136 GLY n 
1 137 GLY n 
1 138 THR n 
1 139 ALA n 
1 140 ALA n 
1 141 LEU n 
1 142 GLY n 
1 143 CYS n 
1 144 LEU n 
1 145 VAL n 
1 146 LYS n 
1 147 ASP n 
1 148 TYR n 
1 149 PHE n 
1 150 PRO n 
1 151 GLU n 
1 152 PRO n 
1 153 VAL n 
1 154 THR n 
1 155 VAL n 
1 156 SER n 
1 157 TRP n 
1 158 ASN n 
1 159 SER n 
1 160 GLY n 
1 161 ALA n 
1 162 LEU n 
1 163 THR n 
1 164 SER n 
1 165 GLY n 
1 166 VAL n 
1 167 HIS n 
1 168 THR n 
1 169 PHE n 
1 170 PRO n 
1 171 ALA n 
1 172 VAL n 
1 173 LEU n 
1 174 GLN n 
1 175 SER n 
1 176 SER n 
1 177 GLY n 
1 178 LEU n 
1 179 TYR n 
1 180 SER n 
1 181 LEU n 
1 182 SER n 
1 183 SER n 
1 184 VAL n 
1 185 VAL n 
1 186 THR n 
1 187 VAL n 
1 188 PRO n 
1 189 SER n 
1 190 SER n 
1 191 SER n 
1 192 LEU n 
1 193 GLY n 
1 194 THR n 
1 195 GLN n 
1 196 THR n 
1 197 TYR n 
1 198 ILE n 
1 199 CYS n 
1 200 ASN n 
1 201 VAL n 
1 202 ASN n 
1 203 HIS n 
1 204 LYS n 
1 205 PRO n 
1 206 SER n 
1 207 ASN n 
1 208 THR n 
1 209 LYS n 
1 210 VAL n 
1 211 ASP n 
1 212 LYS n 
1 213 LYS n 
1 214 VAL n 
1 215 GLU n 
1 216 PRO n 
1 217 LYS n 
1 218 SER n 
1 219 CYS n 
1 220 ASP n 
1 221 LYS n 
1 222 THR n 
1 223 HIS n 
1 224 THR n 
2 1   ASP n 
2 2   ILE n 
2 3   GLN n 
2 4   MET n 
2 5   THR n 
2 6   GLN n 
2 7   SER n 
2 8   PRO n 
2 9   SER n 
2 10  SER n 
2 11  LEU n 
2 12  SER n 
2 13  ALA n 
2 14  SER n 
2 15  VAL n 
2 16  GLY n 
2 17  ASP n 
2 18  ARG n 
2 19  VAL n 
2 20  THR n 
2 21  ILE n 
2 22  THR n 
2 23  CYS n 
2 24  ARG n 
2 25  ALA n 
2 26  SER n 
2 27  GLN n 
2 28  SER n 
2 29  VAL n 
2 30  TRP n 
2 31  ARG n 
2 32  ASN n 
2 33  LYS n 
2 34  ASN n 
2 35  VAL n 
2 36  ALA n 
2 37  TRP n 
2 38  TYR n 
2 39  GLN n 
2 40  GLN n 
2 41  LYS n 
2 42  PRO n 
2 43  GLY n 
2 44  LYS n 
2 45  ALA n 
2 46  PRO n 
2 47  LYS n 
2 48  ARG n 
2 49  LEU n 
2 50  ILE n 
2 51  TYR n 
2 52  ALA n 
2 53  ILE n 
2 54  ALA n 
2 55  SER n 
2 56  LEU n 
2 57  TYR n 
2 58  SER n 
2 59  GLY n 
2 60  VAL n 
2 61  PRO n 
2 62  SER n 
2 63  ARG n 
2 64  PHE n 
2 65  SER n 
2 66  GLY n 
2 67  SER n 
2 68  GLY n 
2 69  SER n 
2 70  GLY n 
2 71  THR n 
2 72  ASP n 
2 73  PHE n 
2 74  THR n 
2 75  LEU n 
2 76  THR n 
2 77  ILE n 
2 78  SER n 
2 79  SER n 
2 80  LEU n 
2 81  GLN n 
2 82  PRO n 
2 83  GLU n 
2 84  ASP n 
2 85  PHE n 
2 86  ALA n 
2 87  THR n 
2 88  TYR n 
2 89  TYR n 
2 90  CYS n 
2 91  VAL n 
2 92  GLY n 
2 93  HIS n 
2 94  TYR n 
2 95  GLY n 
2 96  SER n 
2 97  GLU n 
2 98  ASN n 
2 99  ASP n 
2 100 ALA n 
2 101 TYR n 
2 102 TYR n 
2 103 ALA n 
2 104 PHE n 
2 105 GLY n 
2 106 GLN n 
2 107 GLY n 
2 108 THR n 
2 109 LYS n 
2 110 VAL n 
2 111 GLU n 
2 112 ILE n 
2 113 LYS n 
2 114 ARG n 
2 115 THR n 
2 116 VAL n 
2 117 ALA n 
2 118 ALA n 
2 119 PRO n 
2 120 SER n 
2 121 VAL n 
2 122 PHE n 
2 123 ILE n 
2 124 PHE n 
2 125 PRO n 
2 126 PRO n 
2 127 SER n 
2 128 ASP n 
2 129 GLU n 
2 130 GLN n 
2 131 LEU n 
2 132 LYS n 
2 133 SER n 
2 134 GLY n 
2 135 THR n 
2 136 ALA n 
2 137 SER n 
2 138 VAL n 
2 139 VAL n 
2 140 CYS n 
2 141 LEU n 
2 142 LEU n 
2 143 ASN n 
2 144 ASN n 
2 145 PHE n 
2 146 TYR n 
2 147 PRO n 
2 148 ARG n 
2 149 GLU n 
2 150 ALA n 
2 151 LYS n 
2 152 VAL n 
2 153 SER n 
2 154 TRP n 
2 155 TYR n 
2 156 VAL n 
2 157 ASP n 
2 158 ASN n 
2 159 ALA n 
2 160 LEU n 
2 161 GLN n 
2 162 SER n 
2 163 GLY n 
2 164 ASN n 
2 165 SER n 
2 166 GLN n 
2 167 GLU n 
2 168 SER n 
2 169 VAL n 
2 170 THR n 
2 171 GLU n 
2 172 GLN n 
2 173 ASP n 
2 174 SER n 
2 175 LYS n 
2 176 ASP n 
2 177 SER n 
2 178 THR n 
2 179 TYR n 
2 180 SER n 
2 181 LEU n 
2 182 SER n 
2 183 SER n 
2 184 THR n 
2 185 LEU n 
2 186 THR n 
2 187 LEU n 
2 188 SER n 
2 189 LYS n 
2 190 ALA n 
2 191 ASP n 
2 192 TYR n 
2 193 GLU n 
2 194 LYS n 
2 195 HIS n 
2 196 LYS n 
2 197 VAL n 
2 198 TYR n 
2 199 ALA n 
2 200 CYS n 
2 201 GLU n 
2 202 VAL n 
2 203 THR n 
2 204 GLN n 
2 205 GLY n 
2 206 THR n 
2 207 THR n 
2 208 SER n 
2 209 VAL n 
2 210 THR n 
2 211 LYS n 
2 212 SER n 
2 213 PHE n 
2 214 ASN n 
2 215 ARG n 
2 216 GLY n 
2 217 GLU n 
2 218 CYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 224 ? ? ? ? ? ? ? ? ? 'Oryctolagus cuniculus' 9986 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 218 ? ? ? ? ? ? ? ? ? 'Oryctolagus cuniculus' 9986 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLU 1   1   1   GLU GLU H . n 
A 1 2   VAL 2   2   2   VAL VAL H . n 
A 1 3   GLN 3   3   3   GLN GLN H . n 
A 1 4   LEU 4   4   4   LEU LEU H . n 
A 1 5   VAL 5   5   5   VAL VAL H . n 
A 1 6   GLU 6   6   6   GLU GLU H . n 
A 1 7   SER 7   7   7   SER SER H . n 
A 1 8   GLY 8   8   8   GLY GLY H . n 
A 1 9   GLY 9   9   9   GLY GLY H . n 
A 1 10  GLY 10  10  10  GLY GLY H . n 
A 1 11  LEU 11  11  11  LEU LEU H . n 
A 1 12  VAL 12  12  12  VAL VAL H . n 
A 1 13  GLN 13  13  13  GLN GLN H . n 
A 1 14  PRO 14  14  14  PRO PRO H . n 
A 1 15  GLY 15  15  15  GLY GLY H . n 
A 1 16  GLY 16  16  16  GLY GLY H . n 
A 1 17  SER 17  17  17  SER SER H . n 
A 1 18  LEU 18  18  18  LEU LEU H . n 
A 1 19  ARG 19  19  19  ARG ARG H . n 
A 1 20  LEU 20  20  20  LEU LEU H . n 
A 1 21  SER 21  21  21  SER SER H . n 
A 1 22  CYS 22  22  22  CYS CYS H . n 
A 1 23  THR 23  23  23  THR THR H . n 
A 1 24  ALA 24  24  24  ALA ALA H . n 
A 1 25  SER 25  25  25  SER SER H . n 
A 1 26  GLY 26  26  26  GLY GLY H . n 
A 1 27  PHE 27  27  27  PHE PHE H . n 
A 1 28  SER 28  28  28  SER SER H . n 
A 1 29  ILE 29  29  29  ILE ILE H . n 
A 1 30  ASP 30  30  30  ASP ASP H . n 
A 1 31  SER 31  31  31  SER SER H . n 
A 1 32  TYR 32  32  32  TYR TYR H . n 
A 1 33  GLY 33  33  33  GLY GLY H . n 
A 1 34  PHE 34  34  34  PHE PHE H . n 
A 1 35  SER 35  35  35  SER SER H . n 
A 1 36  TRP 36  36  36  TRP TRP H . n 
A 1 37  VAL 37  37  37  VAL VAL H . n 
A 1 38  ARG 38  38  38  ARG ARG H . n 
A 1 39  GLN 39  39  39  GLN GLN H . n 
A 1 40  ALA 40  40  40  ALA ALA H . n 
A 1 41  PRO 41  41  41  PRO PRO H . n 
A 1 42  GLY 42  42  42  GLY GLY H . n 
A 1 43  LYS 43  43  43  LYS LYS H . n 
A 1 44  GLY 44  44  44  GLY GLY H . n 
A 1 45  LEU 45  45  45  LEU LEU H . n 
A 1 46  GLU 46  46  46  GLU GLU H . n 
A 1 47  HIS 47  47  47  HIS HIS H . n 
A 1 48  ILE 48  48  48  ILE ILE H . n 
A 1 49  GLY 49  49  49  GLY GLY H . n 
A 1 50  TYR 50  50  50  TYR TYR H . n 
A 1 51  LEU 51  51  51  LEU LEU H . n 
A 1 52  THR 52  52  52  THR THR H . n 
A 1 53  ALA 53  53  53  ALA ALA H . n 
A 1 54  GLY 54  54  54  GLY GLY H . n 
A 1 55  GLY 55  55  55  GLY GLY H . n 
A 1 56  ARG 56  56  56  ARG ARG H . n 
A 1 57  ALA 57  57  57  ALA ALA H . n 
A 1 58  PHE 58  58  58  PHE PHE H . n 
A 1 59  TYR 59  59  59  TYR TYR H . n 
A 1 60  ALA 60  60  60  ALA ALA H . n 
A 1 61  SER 61  61  61  SER SER H . n 
A 1 62  TRP 62  62  62  TRP TRP H . n 
A 1 63  ALA 63  63  63  ALA ALA H . n 
A 1 64  LYS 64  64  64  LYS LYS H . n 
A 1 65  SER 65  65  65  SER SER H . n 
A 1 66  ARG 66  66  66  ARG ARG H . n 
A 1 67  SER 67  67  67  SER SER H . n 
A 1 68  THR 68  68  68  THR THR H . n 
A 1 69  ILE 69  69  69  ILE ILE H . n 
A 1 70  THR 70  70  70  THR THR H . n 
A 1 71  ARG 71  71  71  ARG ARG H . n 
A 1 72  ASN 72  72  72  ASN ASN H . n 
A 1 73  THR 73  73  73  THR THR H . n 
A 1 74  ASN 74  74  74  ASN ASN H . n 
A 1 75  GLU 75  75  75  GLU GLU H . n 
A 1 76  ASN 76  76  76  ASN ASN H . n 
A 1 77  THR 77  77  77  THR THR H . n 
A 1 78  VAL 78  78  78  VAL VAL H . n 
A 1 79  THR 79  79  79  THR THR H . n 
A 1 80  LEU 80  80  80  LEU LEU H . n 
A 1 81  LYS 81  81  81  LYS LYS H . n 
A 1 82  MET 82  82  82  MET MET H . n 
A 1 83  ASN 83  82  82  ASN ASN H A n 
A 1 84  SER 84  82  82  SER SER H B n 
A 1 85  LEU 85  82  82  LEU LEU H C n 
A 1 86  ARG 86  83  83  ARG ARG H . n 
A 1 87  ALA 87  84  84  ALA ALA H . n 
A 1 88  GLU 88  85  85  GLU GLU H . n 
A 1 89  ASP 89  86  86  ASP ASP H . n 
A 1 90  THR 90  87  87  THR THR H . n 
A 1 91  ALA 91  88  88  ALA ALA H . n 
A 1 92  VAL 92  89  89  VAL VAL H . n 
A 1 93  TYR 93  90  90  TYR TYR H . n 
A 1 94  TYR 94  91  91  TYR TYR H . n 
A 1 95  CYS 95  92  92  CYS CYS H . n 
A 1 96  ALA 96  93  93  ALA ALA H . n 
A 1 97  LYS 97  94  94  LYS LYS H . n 
A 1 98  LEU 98  95  95  LEU LEU H . n 
A 1 99  GLY 99  96  96  GLY GLY H . n 
A 1 100 THR 100 97  97  THR THR H . n 
A 1 101 GLY 101 98  98  GLY GLY H . n 
A 1 102 SER 102 99  99  SER SER H . n 
A 1 103 ARG 103 100 100 ARG ARG H . n 
A 1 104 PHE 104 100 100 PHE PHE H A n 
A 1 105 ALA 105 101 101 ALA ALA H . n 
A 1 106 ILE 106 102 102 ILE ILE H . n 
A 1 107 TRP 107 103 103 TRP TRP H . n 
A 1 108 GLY 108 104 104 GLY GLY H . n 
A 1 109 GLN 109 105 105 GLN GLN H . n 
A 1 110 GLY 110 106 106 GLY GLY H . n 
A 1 111 THR 111 107 107 THR THR H . n 
A 1 112 LEU 112 108 108 LEU LEU H . n 
A 1 113 VAL 113 109 109 VAL VAL H . n 
A 1 114 THR 114 110 110 THR THR H . n 
A 1 115 VAL 115 111 111 VAL VAL H . n 
A 1 116 PHE 116 112 112 PHE PHE H . n 
A 1 117 ASN 117 113 113 ASN ASN H . n 
A 1 118 GLN 118 114 114 GLN GLN H . n 
A 1 119 ILE 119 115 115 ILE ILE H . n 
A 1 120 LYS 120 116 116 LYS LYS H . n 
A 1 121 GLY 121 117 117 GLY GLY H . n 
A 1 122 PRO 122 118 118 PRO PRO H . n 
A 1 123 SER 123 119 119 SER SER H . n 
A 1 124 VAL 124 120 120 VAL VAL H . n 
A 1 125 PHE 125 121 121 PHE PHE H . n 
A 1 126 PRO 126 122 122 PRO PRO H . n 
A 1 127 LEU 127 123 123 LEU LEU H . n 
A 1 128 ALA 128 124 124 ALA ALA H . n 
A 1 129 PRO 129 125 125 PRO PRO H . n 
A 1 130 SER 130 126 126 SER SER H . n 
A 1 131 SER 131 127 127 SER SER H . n 
A 1 132 LYS 132 128 128 LYS LYS H . n 
A 1 133 SER 133 129 129 SER SER H . n 
A 1 134 THR 134 130 ?   ?   ?   H . n 
A 1 135 SER 135 131 ?   ?   ?   H . n 
A 1 136 GLY 136 132 132 GLY GLY H . n 
A 1 137 GLY 137 133 133 GLY GLY H . n 
A 1 138 THR 138 134 134 THR THR H . n 
A 1 139 ALA 139 135 135 ALA ALA H . n 
A 1 140 ALA 140 136 136 ALA ALA H . n 
A 1 141 LEU 141 137 137 LEU LEU H . n 
A 1 142 GLY 142 138 138 GLY GLY H . n 
A 1 143 CYS 143 139 139 CYS CYS H . n 
A 1 144 LEU 144 140 140 LEU LEU H . n 
A 1 145 VAL 145 141 141 VAL VAL H . n 
A 1 146 LYS 146 142 142 LYS LYS H . n 
A 1 147 ASP 147 143 143 ASP ASP H . n 
A 1 148 TYR 148 144 144 TYR TYR H . n 
A 1 149 PHE 149 145 145 PHE PHE H . n 
A 1 150 PRO 150 146 146 PRO PRO H . n 
A 1 151 GLU 151 147 147 GLU GLU H . n 
A 1 152 PRO 152 148 148 PRO PRO H . n 
A 1 153 VAL 153 149 149 VAL VAL H . n 
A 1 154 THR 154 150 150 THR THR H . n 
A 1 155 VAL 155 151 151 VAL VAL H . n 
A 1 156 SER 156 152 152 SER SER H . n 
A 1 157 TRP 157 153 153 TRP TRP H . n 
A 1 158 ASN 158 154 154 ASN ASN H . n 
A 1 159 SER 159 155 155 SER SER H . n 
A 1 160 GLY 160 156 156 GLY GLY H . n 
A 1 161 ALA 161 157 157 ALA ALA H . n 
A 1 162 LEU 162 158 158 LEU LEU H . n 
A 1 163 THR 163 159 159 THR THR H . n 
A 1 164 SER 164 160 160 SER SER H . n 
A 1 165 GLY 165 161 161 GLY GLY H . n 
A 1 166 VAL 166 162 162 VAL VAL H . n 
A 1 167 HIS 167 163 163 HIS HIS H . n 
A 1 168 THR 168 164 164 THR THR H . n 
A 1 169 PHE 169 165 165 PHE PHE H . n 
A 1 170 PRO 170 166 166 PRO PRO H . n 
A 1 171 ALA 171 167 167 ALA ALA H . n 
A 1 172 VAL 172 168 168 VAL VAL H . n 
A 1 173 LEU 173 169 169 LEU LEU H . n 
A 1 174 GLN 174 170 170 GLN GLN H . n 
A 1 175 SER 175 171 171 SER SER H . n 
A 1 176 SER 176 172 172 SER SER H . n 
A 1 177 GLY 177 173 173 GLY GLY H . n 
A 1 178 LEU 178 174 174 LEU LEU H . n 
A 1 179 TYR 179 175 175 TYR TYR H . n 
A 1 180 SER 180 176 176 SER SER H . n 
A 1 181 LEU 181 177 177 LEU LEU H . n 
A 1 182 SER 182 178 178 SER SER H . n 
A 1 183 SER 183 179 179 SER SER H . n 
A 1 184 VAL 184 180 180 VAL VAL H . n 
A 1 185 VAL 185 181 181 VAL VAL H . n 
A 1 186 THR 186 182 182 THR THR H . n 
A 1 187 VAL 187 183 183 VAL VAL H . n 
A 1 188 PRO 188 184 184 PRO PRO H . n 
A 1 189 SER 189 185 185 SER SER H . n 
A 1 190 SER 190 186 186 SER SER H . n 
A 1 191 SER 191 187 187 SER SER H . n 
A 1 192 LEU 192 188 188 LEU LEU H . n 
A 1 193 GLY 193 189 189 GLY GLY H . n 
A 1 194 THR 194 190 190 THR THR H . n 
A 1 195 GLN 195 191 191 GLN GLN H . n 
A 1 196 THR 196 192 192 THR THR H . n 
A 1 197 TYR 197 193 193 TYR TYR H . n 
A 1 198 ILE 198 194 194 ILE ILE H . n 
A 1 199 CYS 199 195 195 CYS CYS H . n 
A 1 200 ASN 200 196 196 ASN ASN H . n 
A 1 201 VAL 201 197 197 VAL VAL H . n 
A 1 202 ASN 202 198 198 ASN ASN H . n 
A 1 203 HIS 203 199 199 HIS HIS H . n 
A 1 204 LYS 204 200 200 LYS LYS H . n 
A 1 205 PRO 205 201 201 PRO PRO H . n 
A 1 206 SER 206 202 202 SER SER H . n 
A 1 207 ASN 207 203 203 ASN ASN H . n 
A 1 208 THR 208 204 204 THR THR H . n 
A 1 209 LYS 209 205 205 LYS LYS H . n 
A 1 210 VAL 210 206 206 VAL VAL H . n 
A 1 211 ASP 211 207 207 ASP ASP H . n 
A 1 212 LYS 212 208 208 LYS LYS H . n 
A 1 213 LYS 213 209 209 LYS LYS H . n 
A 1 214 VAL 214 210 210 VAL VAL H . n 
A 1 215 GLU 215 211 211 GLU GLU H . n 
A 1 216 PRO 216 212 212 PRO PRO H . n 
A 1 217 LYS 217 213 213 LYS LYS H . n 
A 1 218 SER 218 214 ?   ?   ?   H . n 
A 1 219 CYS 219 215 ?   ?   ?   H . n 
A 1 220 ASP 220 216 ?   ?   ?   H . n 
A 1 221 LYS 221 217 ?   ?   ?   H . n 
A 1 222 THR 222 218 ?   ?   ?   H . n 
A 1 223 HIS 223 219 ?   ?   ?   H . n 
A 1 224 THR 224 220 ?   ?   ?   H . n 
B 2 1   ASP 1   1   1   ASP ASP L . n 
B 2 2   ILE 2   2   2   ILE ILE L . n 
B 2 3   GLN 3   3   3   GLN GLN L . n 
B 2 4   MET 4   4   4   MET MET L . n 
B 2 5   THR 5   5   5   THR THR L . n 
B 2 6   GLN 6   6   6   GLN GLN L . n 
B 2 7   SER 7   7   7   SER SER L . n 
B 2 8   PRO 8   8   8   PRO PRO L . n 
B 2 9   SER 9   9   9   SER SER L . n 
B 2 10  SER 10  10  10  SER SER L . n 
B 2 11  LEU 11  11  11  LEU LEU L . n 
B 2 12  SER 12  12  12  SER SER L . n 
B 2 13  ALA 13  13  13  ALA ALA L . n 
B 2 14  SER 14  14  14  SER SER L . n 
B 2 15  VAL 15  15  15  VAL VAL L . n 
B 2 16  GLY 16  16  16  GLY GLY L . n 
B 2 17  ASP 17  17  17  ASP ASP L . n 
B 2 18  ARG 18  18  18  ARG ARG L . n 
B 2 19  VAL 19  19  19  VAL VAL L . n 
B 2 20  THR 20  20  20  THR THR L . n 
B 2 21  ILE 21  21  21  ILE ILE L . n 
B 2 22  THR 22  22  22  THR THR L . n 
B 2 23  CYS 23  23  23  CYS CYS L . n 
B 2 24  ARG 24  24  24  ARG ARG L . n 
B 2 25  ALA 25  25  25  ALA ALA L . n 
B 2 26  SER 26  26  26  SER SER L . n 
B 2 27  GLN 27  27  27  GLN GLN L . n 
B 2 28  SER 28  27  27  SER SER L A n 
B 2 29  VAL 29  27  27  VAL VAL L B n 
B 2 30  TRP 30  28  28  TRP TRP L . n 
B 2 31  ARG 31  29  29  ARG ARG L . n 
B 2 32  ASN 32  30  30  ASN ASN L . n 
B 2 33  LYS 33  31  31  LYS LYS L . n 
B 2 34  ASN 34  32  32  ASN ASN L . n 
B 2 35  VAL 35  33  33  VAL VAL L . n 
B 2 36  ALA 36  34  34  ALA ALA L . n 
B 2 37  TRP 37  35  35  TRP TRP L . n 
B 2 38  TYR 38  36  36  TYR TYR L . n 
B 2 39  GLN 39  37  37  GLN GLN L . n 
B 2 40  GLN 40  38  38  GLN GLN L . n 
B 2 41  LYS 41  39  39  LYS LYS L . n 
B 2 42  PRO 42  40  40  PRO PRO L . n 
B 2 43  GLY 43  41  41  GLY GLY L . n 
B 2 44  LYS 44  42  42  LYS LYS L . n 
B 2 45  ALA 45  43  43  ALA ALA L . n 
B 2 46  PRO 46  44  44  PRO PRO L . n 
B 2 47  LYS 47  45  45  LYS LYS L . n 
B 2 48  ARG 48  46  46  ARG ARG L . n 
B 2 49  LEU 49  47  47  LEU LEU L . n 
B 2 50  ILE 50  48  48  ILE ILE L . n 
B 2 51  TYR 51  49  49  TYR TYR L . n 
B 2 52  ALA 52  50  50  ALA ALA L . n 
B 2 53  ILE 53  51  51  ILE ILE L . n 
B 2 54  ALA 54  52  52  ALA ALA L . n 
B 2 55  SER 55  53  53  SER SER L . n 
B 2 56  LEU 56  54  54  LEU LEU L . n 
B 2 57  TYR 57  55  55  TYR TYR L . n 
B 2 58  SER 58  56  56  SER SER L . n 
B 2 59  GLY 59  57  57  GLY GLY L . n 
B 2 60  VAL 60  58  58  VAL VAL L . n 
B 2 61  PRO 61  59  59  PRO PRO L . n 
B 2 62  SER 62  60  60  SER SER L . n 
B 2 63  ARG 63  61  61  ARG ARG L . n 
B 2 64  PHE 64  62  62  PHE PHE L . n 
B 2 65  SER 65  63  63  SER SER L . n 
B 2 66  GLY 66  64  64  GLY GLY L . n 
B 2 67  SER 67  65  65  SER SER L . n 
B 2 68  GLY 68  66  66  GLY GLY L . n 
B 2 69  SER 69  67  67  SER SER L . n 
B 2 70  GLY 70  68  68  GLY GLY L . n 
B 2 71  THR 71  69  69  THR THR L . n 
B 2 72  ASP 72  70  70  ASP ASP L . n 
B 2 73  PHE 73  71  71  PHE PHE L . n 
B 2 74  THR 74  72  72  THR THR L . n 
B 2 75  LEU 75  73  73  LEU LEU L . n 
B 2 76  THR 76  74  74  THR THR L . n 
B 2 77  ILE 77  75  75  ILE ILE L . n 
B 2 78  SER 78  76  76  SER SER L . n 
B 2 79  SER 79  77  77  SER SER L . n 
B 2 80  LEU 80  78  78  LEU LEU L . n 
B 2 81  GLN 81  79  79  GLN GLN L . n 
B 2 82  PRO 82  80  80  PRO PRO L . n 
B 2 83  GLU 83  81  81  GLU GLU L . n 
B 2 84  ASP 84  82  82  ASP ASP L . n 
B 2 85  PHE 85  83  83  PHE PHE L . n 
B 2 86  ALA 86  84  84  ALA ALA L . n 
B 2 87  THR 87  85  85  THR THR L . n 
B 2 88  TYR 88  86  86  TYR TYR L . n 
B 2 89  TYR 89  87  87  TYR TYR L . n 
B 2 90  CYS 90  88  88  CYS CYS L . n 
B 2 91  VAL 91  89  89  VAL VAL L . n 
B 2 92  GLY 92  90  90  GLY GLY L . n 
B 2 93  HIS 93  91  91  HIS HIS L . n 
B 2 94  TYR 94  92  92  TYR TYR L . n 
B 2 95  GLY 95  93  93  GLY GLY L . n 
B 2 96  SER 96  94  94  SER SER L . n 
B 2 97  GLU 97  95  95  GLU GLU L . n 
B 2 98  ASN 98  95  95  ASN ASN L A n 
B 2 99  ASP 99  95  95  ASP ASP L B n 
B 2 100 ALA 100 95  95  ALA ALA L C n 
B 2 101 TYR 101 95  95  TYR TYR L D n 
B 2 102 TYR 102 96  96  TYR TYR L . n 
B 2 103 ALA 103 97  97  ALA ALA L . n 
B 2 104 PHE 104 98  98  PHE PHE L . n 
B 2 105 GLY 105 99  99  GLY GLY L . n 
B 2 106 GLN 106 100 100 GLN GLN L . n 
B 2 107 GLY 107 101 101 GLY GLY L . n 
B 2 108 THR 108 102 102 THR THR L . n 
B 2 109 LYS 109 103 103 LYS LYS L . n 
B 2 110 VAL 110 104 104 VAL VAL L . n 
B 2 111 GLU 111 105 105 GLU GLU L . n 
B 2 112 ILE 112 106 106 ILE ILE L . n 
B 2 113 LYS 113 107 107 LYS LYS L . n 
B 2 114 ARG 114 108 108 ARG ARG L . n 
B 2 115 THR 115 109 109 THR THR L . n 
B 2 116 VAL 116 110 110 VAL VAL L . n 
B 2 117 ALA 117 111 111 ALA ALA L . n 
B 2 118 ALA 118 112 112 ALA ALA L . n 
B 2 119 PRO 119 113 113 PRO PRO L . n 
B 2 120 SER 120 114 114 SER SER L . n 
B 2 121 VAL 121 115 115 VAL VAL L . n 
B 2 122 PHE 122 116 116 PHE PHE L . n 
B 2 123 ILE 123 117 117 ILE ILE L . n 
B 2 124 PHE 124 118 118 PHE PHE L . n 
B 2 125 PRO 125 119 119 PRO PRO L . n 
B 2 126 PRO 126 120 120 PRO PRO L . n 
B 2 127 SER 127 121 121 SER SER L . n 
B 2 128 ASP 128 122 122 ASP ASP L . n 
B 2 129 GLU 129 123 123 GLU GLU L . n 
B 2 130 GLN 130 124 124 GLN GLN L . n 
B 2 131 LEU 131 125 125 LEU LEU L . n 
B 2 132 LYS 132 126 126 LYS LYS L . n 
B 2 133 SER 133 127 127 SER SER L . n 
B 2 134 GLY 134 128 128 GLY GLY L . n 
B 2 135 THR 135 129 129 THR THR L . n 
B 2 136 ALA 136 130 130 ALA ALA L . n 
B 2 137 SER 137 131 131 SER SER L . n 
B 2 138 VAL 138 132 132 VAL VAL L . n 
B 2 139 VAL 139 133 133 VAL VAL L . n 
B 2 140 CYS 140 134 134 CYS CYS L . n 
B 2 141 LEU 141 135 135 LEU LEU L . n 
B 2 142 LEU 142 136 136 LEU LEU L . n 
B 2 143 ASN 143 137 137 ASN ASN L . n 
B 2 144 ASN 144 138 138 ASN ASN L . n 
B 2 145 PHE 145 139 139 PHE PHE L . n 
B 2 146 TYR 146 140 140 TYR TYR L . n 
B 2 147 PRO 147 141 141 PRO PRO L . n 
B 2 148 ARG 148 142 142 ARG ARG L . n 
B 2 149 GLU 149 143 143 GLU GLU L . n 
B 2 150 ALA 150 144 144 ALA ALA L . n 
B 2 151 LYS 151 145 145 LYS LYS L . n 
B 2 152 VAL 152 146 146 VAL VAL L . n 
B 2 153 SER 153 147 147 SER SER L . n 
B 2 154 TRP 154 148 148 TRP TRP L . n 
B 2 155 TYR 155 149 149 TYR TYR L . n 
B 2 156 VAL 156 150 150 VAL VAL L . n 
B 2 157 ASP 157 151 151 ASP ASP L . n 
B 2 158 ASN 158 152 152 ASN ASN L . n 
B 2 159 ALA 159 153 153 ALA ALA L . n 
B 2 160 LEU 160 154 154 LEU LEU L . n 
B 2 161 GLN 161 155 155 GLN GLN L . n 
B 2 162 SER 162 156 156 SER SER L . n 
B 2 163 GLY 163 157 157 GLY GLY L . n 
B 2 164 ASN 164 158 158 ASN ASN L . n 
B 2 165 SER 165 159 159 SER SER L . n 
B 2 166 GLN 166 160 160 GLN GLN L . n 
B 2 167 GLU 167 161 161 GLU GLU L . n 
B 2 168 SER 168 162 162 SER SER L . n 
B 2 169 VAL 169 163 163 VAL VAL L . n 
B 2 170 THR 170 164 164 THR THR L . n 
B 2 171 GLU 171 165 165 GLU GLU L . n 
B 2 172 GLN 172 166 166 GLN GLN L . n 
B 2 173 ASP 173 167 167 ASP ASP L . n 
B 2 174 SER 174 168 168 SER SER L . n 
B 2 175 LYS 175 169 169 LYS LYS L . n 
B 2 176 ASP 176 170 170 ASP ASP L . n 
B 2 177 SER 177 171 171 SER SER L . n 
B 2 178 THR 178 172 172 THR THR L . n 
B 2 179 TYR 179 173 173 TYR TYR L . n 
B 2 180 SER 180 174 174 SER SER L . n 
B 2 181 LEU 181 175 175 LEU LEU L . n 
B 2 182 SER 182 176 176 SER SER L . n 
B 2 183 SER 183 177 177 SER SER L . n 
B 2 184 THR 184 178 178 THR THR L . n 
B 2 185 LEU 185 179 179 LEU LEU L . n 
B 2 186 THR 186 180 180 THR THR L . n 
B 2 187 LEU 187 181 181 LEU LEU L . n 
B 2 188 SER 188 182 182 SER SER L . n 
B 2 189 LYS 189 183 183 LYS LYS L . n 
B 2 190 ALA 190 184 184 ALA ALA L . n 
B 2 191 ASP 191 185 185 ASP ASP L . n 
B 2 192 TYR 192 186 186 TYR TYR L . n 
B 2 193 GLU 193 187 187 GLU GLU L . n 
B 2 194 LYS 194 188 188 LYS LYS L . n 
B 2 195 HIS 195 189 189 HIS HIS L . n 
B 2 196 LYS 196 190 190 LYS LYS L . n 
B 2 197 VAL 197 191 191 VAL VAL L . n 
B 2 198 TYR 198 192 192 TYR TYR L . n 
B 2 199 ALA 199 193 193 ALA ALA L . n 
B 2 200 CYS 200 194 194 CYS CYS L . n 
B 2 201 GLU 201 195 195 GLU GLU L . n 
B 2 202 VAL 202 196 196 VAL VAL L . n 
B 2 203 THR 203 197 197 THR THR L . n 
B 2 204 GLN 204 198 198 GLN GLN L . n 
B 2 205 GLY 205 199 199 GLY GLY L . n 
B 2 206 THR 206 200 200 THR THR L . n 
B 2 207 THR 207 201 201 THR THR L . n 
B 2 208 SER 208 202 202 SER SER L . n 
B 2 209 VAL 209 203 203 VAL VAL L . n 
B 2 210 THR 210 204 204 THR THR L . n 
B 2 211 LYS 211 205 205 LYS LYS L . n 
B 2 212 SER 212 206 206 SER SER L . n 
B 2 213 PHE 213 207 207 PHE PHE L . n 
B 2 214 ASN 214 208 208 ASN ASN L . n 
B 2 215 ARG 215 209 209 ARG ARG L . n 
B 2 216 GLY 216 210 210 GLY GLY L . n 
B 2 217 GLU 217 211 211 GLU GLU L . n 
B 2 218 CYS 218 212 212 CYS CYS L . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1 301 6  HOH HOH H . 
C 3 HOH 2 302 4  HOH HOH H . 
C 3 HOH 3 303 3  HOH HOH H . 
C 3 HOH 4 304 7  HOH HOH H . 
D 3 HOH 1 301 10 HOH HOH L . 
D 3 HOH 2 302 5  HOH HOH L . 
D 3 HOH 3 303 1  HOH HOH L . 
D 3 HOH 4 304 2  HOH HOH L . 
D 3 HOH 5 305 8  HOH HOH L . 
D 3 HOH 6 306 9  HOH HOH L . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8UHT 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     49.745 
_cell.length_a_esd                 ? 
_cell.length_b                     73.275 
_cell.length_b_esd                 ? 
_cell.length_c                     148.455 
_cell.length_c_esd                 ? 
_cell.volume                       541128.106 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8UHT 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8UHT 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.85 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.77 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Tris, pH 8.5, 8% PEG8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 2M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-12-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97741 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97741 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.1 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          53.43 
_reflns.entry_id                                       8UHT 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.45 
_reflns.d_resolution_low                               47.17 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     19822 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     0.0 
_reflns.observed_criterion_sigma_I                     -3.0 
_reflns.percent_possible_obs                           96.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          29.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.19 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.069 
_reflns.pdbx_Rpim_I_all                                0.027 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   1.0 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.063 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.063 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.45 
_reflns_shell.d_res_low                                     2.49 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.98 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             839 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.7 
_reflns_shell.pdbx_chi_squared                              1.15 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.941 
_reflns_shell.pdbx_Rpim_I_all                               0.387 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.709 
_reflns_shell.pdbx_CC_star                                  0.911 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          84.2 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.854 
_reflns_shell.pdbx_Rsym_value                               0.854 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               62.71 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8UHT 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.45 
_refine.ls_d_res_low                             47.17 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     19778 
_refine.ls_number_reflns_R_free                  985 
_refine.ls_number_reflns_R_work                  18793 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.22 
_refine.ls_percent_reflns_R_free                 4.98 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2465 
_refine.ls_R_factor_R_free                       0.2895 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2441 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.7634 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.4574 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.45 
_refine_hist.d_res_low                        47.17 
_refine_hist.number_atoms_solvent             10 
_refine_hist.number_atoms_total               3287 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3277 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0049  ? 3362 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7118  ? 4572 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0465  ? 515  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0054  ? 584  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.9473 ? 1198 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.45 2.58  . . 116 2344 85.89 . . . . 0.3629 . . . . . . . . . . . 0.4547 
'X-RAY DIFFRACTION' 2.58 2.75  . . 132 2544 92.21 . . . . 0.3691 . . . . . . . . . . . 0.4135 
'X-RAY DIFFRACTION' 2.75 2.96  . . 133 2691 97.82 . . . . 0.3464 . . . . . . . . . . . 0.4768 
'X-RAY DIFFRACTION' 2.96 3.25  . . 125 2754 99.21 . . . . 0.3158 . . . . . . . . . . . 0.3521 
'X-RAY DIFFRACTION' 3.26 3.73  . . 149 2746 99.14 . . . . 0.2839 . . . . . . . . . . . 0.3223 
'X-RAY DIFFRACTION' 3.73 4.69  . . 169 2774 99.43 . . . . 0.2029 . . . . . . . . . . . 0.2831 
'X-RAY DIFFRACTION' 4.69 47.17 . . 161 2940 99.42 . . . . 0.1757 . . . . . . . . . . . 0.1932 
# 
_struct.entry_id                     8UHT 
_struct.title                        'anti-Phosphohistidine Fab hSC44.ck.20.elbow bound to Glu H1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8UHT 
_struct_keywords.text            
'ANTI-PHOSPHOHISTIDINE ANTIBODY POST-TRANSLATIONAL MODIFICATION ANTIBODY HUMANIZATION, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8UHT 8UHT ? 1 ? 1 
2 PDB 8UHT 8UHT ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8UHT H 1 ? 224 ? 8UHT 1 ? 220 ? 1 220 
2 2 8UHT L 1 ? 218 ? 8UHT 1 ? 212 ? 1 212 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3800  ? 
1 MORE         -23   ? 
1 'SSA (A^2)'  20160 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 60  ? SER A 65  ? ALA H 60  SER H 65  1 ? 6 
HELX_P HELX_P2 AA2 ARG A 86  ? THR A 90  ? ARG H 83  THR H 87  5 ? 5 
HELX_P HELX_P3 AA3 SER A 190 ? THR A 194 ? SER H 186 THR H 190 5 ? 5 
HELX_P HELX_P4 AA4 LYS A 204 ? ASN A 207 ? LYS H 200 ASN H 203 5 ? 4 
HELX_P HELX_P5 AA5 GLN B 81  ? PHE B 85  ? GLN L 79  PHE L 83  5 ? 5 
HELX_P HELX_P6 AA6 SER B 127 ? LYS B 132 ? SER L 121 LYS L 126 1 ? 6 
HELX_P HELX_P7 AA7 LYS B 189 ? HIS B 195 ? LYS L 183 HIS L 189 1 ? 7 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 22  SG ? ? ? 1_555 A CYS 95  SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.015 ? ? 
disulf2 disulf ? ? A CYS 143 SG A ? ? 1_555 A CYS 199 SG ? ? H CYS 139 H CYS 195 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf3 disulf ? ? B CYS 23  SG ? ? ? 1_555 B CYS 90  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.039 ? ? 
disulf4 disulf ? ? B CYS 140 SG ? ? ? 1_555 B CYS 200 SG A ? L CYS 134 L CYS 194 1_555 ? ? ? ? ? ? ? 2.049 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 22  ? CYS A 95  ? CYS H 22  ? 1_555 CYS H 92  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 143 A CYS A 199 ? CYS H 139 ? 1_555 CYS H 195 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 23  ? CYS B 90  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 140 ? CYS B 200 A CYS L 134 ? 1_555 CYS L 194 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 149 A . ? PHE 145 H PRO 150 A ? PRO 146 H 1 -8.49 
2 GLU 151 A . ? GLU 147 H PRO 152 A ? PRO 148 H 1 -2.43 
3 SER 7   B . ? SER 7   L PRO 8   B ? PRO 8   L 1 -6.54 
4 TYR 146 B . ? TYR 140 L PRO 147 B ? PRO 141 L 1 -1.68 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 3 ? 
AA7 ? 4 ? 
AA8 ? 6 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
AA8 5 6 ? anti-parallel 
AA9 1 2 ? parallel      
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 4   ? SER A 7   ? LEU H 4   SER H 7   
AA1 2 ARG A 19  ? ALA A 24  ? ARG H 19  ALA H 24  
AA1 3 THR A 77  ? LYS A 81  ? THR H 77  LYS H 81  
AA1 4 THR A 68  ? ASN A 72  ? THR H 68  ASN H 72  
AA2 1 GLY A 10  ? VAL A 12  ? GLY H 10  VAL H 12  
AA2 2 THR A 111 ? VAL A 115 ? THR H 107 VAL H 111 
AA2 3 ALA A 91  ? LYS A 97  ? ALA H 88  LYS H 94  
AA2 4 PHE A 34  ? GLN A 39  ? PHE H 34  GLN H 39  
AA2 5 LEU A 45  ? LEU A 51  ? LEU H 45  LEU H 51  
AA2 6 ALA A 57  ? TYR A 59  ? ALA H 57  TYR H 59  
AA3 1 GLY A 10  ? VAL A 12  ? GLY H 10  VAL H 12  
AA3 2 THR A 111 ? VAL A 115 ? THR H 107 VAL H 111 
AA3 3 ALA A 91  ? LYS A 97  ? ALA H 88  LYS H 94  
AA3 4 ILE A 106 ? TRP A 107 ? ILE H 102 TRP H 103 
AA4 1 SER A 123 ? LEU A 127 ? SER H 119 LEU H 123 
AA4 2 THR A 138 ? TYR A 148 ? THR H 134 TYR H 144 
AA4 3 TYR A 179 ? PRO A 188 ? TYR H 175 PRO H 184 
AA4 4 VAL A 166 ? THR A 168 ? VAL H 162 THR H 164 
AA5 1 SER A 123 ? LEU A 127 ? SER H 119 LEU H 123 
AA5 2 THR A 138 ? TYR A 148 ? THR H 134 TYR H 144 
AA5 3 TYR A 179 ? PRO A 188 ? TYR H 175 PRO H 184 
AA5 4 VAL A 172 ? LEU A 173 ? VAL H 168 LEU H 169 
AA6 1 THR A 154 ? TRP A 157 ? THR H 150 TRP H 153 
AA6 2 ILE A 198 ? HIS A 203 ? ILE H 194 HIS H 199 
AA6 3 THR A 208 ? LYS A 213 ? THR H 204 LYS H 209 
AA7 1 MET B 4   ? SER B 7   ? MET L 4   SER L 7   
AA7 2 VAL B 19  ? ALA B 25  ? VAL L 19  ALA L 25  
AA7 3 PHE B 73  ? ILE B 77  ? PHE L 71  ILE L 75  
AA7 4 PHE B 64  ? SER B 67  ? PHE L 62  SER L 65  
AA8 1 SER B 10  ? SER B 12  ? SER L 10  SER L 12  
AA8 2 THR B 108 ? GLU B 111 ? THR L 102 GLU L 105 
AA8 3 THR B 87  ? GLY B 95  ? THR L 85  GLY L 93  
AA8 4 VAL B 35  ? GLN B 40  ? VAL L 33  GLN L 38  
AA8 5 LYS B 47  ? TYR B 51  ? LYS L 45  TYR L 49  
AA8 6 SER B 55  ? LEU B 56  ? SER L 53  LEU L 54  
AA9 1 SER B 10  ? SER B 12  ? SER L 10  SER L 12  
AA9 2 THR B 108 ? GLU B 111 ? THR L 102 GLU L 105 
AA9 3 THR B 87  ? GLY B 95  ? THR L 85  GLY L 93  
AA9 4 ALA B 100 C PHE B 104 ? ALA L 95  PHE L 98  
AB1 1 SER B 120 ? PHE B 124 ? SER L 114 PHE L 118 
AB1 2 THR B 135 ? PHE B 145 ? THR L 129 PHE L 139 
AB1 3 TYR B 179 ? SER B 188 ? TYR L 173 SER L 182 
AB1 4 SER B 165 ? VAL B 169 ? SER L 159 VAL L 163 
AB2 1 ALA B 159 ? LEU B 160 ? ALA L 153 LEU L 154 
AB2 2 LYS B 151 ? VAL B 156 ? LYS L 145 VAL L 150 
AB2 3 VAL B 197 ? GLN B 204 ? VAL L 191 GLN L 198 
AB2 4 THR B 207 ? ASN B 214 ? THR L 201 ASN L 208 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 5   ? N VAL H 5   O THR A 23  ? O THR H 23  
AA1 2 3 N CYS A 22  ? N CYS H 22  O VAL A 78  ? O VAL H 78  
AA1 3 4 O THR A 79  ? O THR H 79  N THR A 70  ? N THR H 70  
AA2 1 2 N VAL A 12  ? N VAL H 12  O THR A 114 ? O THR H 110 
AA2 2 3 O THR A 111 ? O THR H 107 N TYR A 93  ? N TYR H 90  
AA2 3 4 O TYR A 94  ? O TYR H 91  N VAL A 37  ? N VAL H 37  
AA2 4 5 N TRP A 36  ? N TRP H 36  O GLY A 49  ? O GLY H 49  
AA2 5 6 N TYR A 50  ? N TYR H 50  O PHE A 58  ? O PHE H 58  
AA3 1 2 N VAL A 12  ? N VAL H 12  O THR A 114 ? O THR H 110 
AA3 2 3 O THR A 111 ? O THR H 107 N TYR A 93  ? N TYR H 90  
AA3 3 4 N LYS A 97  ? N LYS H 94  O ILE A 106 ? O ILE H 102 
AA4 1 2 N PHE A 125 ? N PHE H 121 O LEU A 144 ? O LEU H 140 
AA4 2 3 N VAL A 145 ? N VAL H 141 O LEU A 181 ? O LEU H 177 
AA4 3 4 O VAL A 184 ? O VAL H 180 N HIS A 167 ? N HIS H 163 
AA5 1 2 N PHE A 125 ? N PHE H 121 O LEU A 144 ? O LEU H 140 
AA5 2 3 N VAL A 145 ? N VAL H 141 O LEU A 181 ? O LEU H 177 
AA5 3 4 O SER A 180 ? O SER H 176 N VAL A 172 ? N VAL H 168 
AA6 1 2 N SER A 156 ? N SER H 152 O ASN A 200 ? O ASN H 196 
AA6 2 3 N HIS A 203 ? N HIS H 199 O THR A 208 ? O THR H 204 
AA7 1 2 N THR B 5   ? N THR L 5   O ARG B 24  ? O ARG L 24  
AA7 2 3 N ILE B 21  ? N ILE L 21  O LEU B 75  ? O LEU L 73  
AA7 3 4 O THR B 76  ? O THR L 74  N SER B 65  ? N SER L 63  
AA8 1 2 N LEU B 11  ? N LEU L 11  O GLU B 111 ? O GLU L 105 
AA8 2 3 O THR B 108 ? O THR L 102 N TYR B 88  ? N TYR L 86  
AA8 3 4 O TYR B 89  ? O TYR L 87  N TYR B 38  ? N TYR L 36  
AA8 4 5 N GLN B 39  ? N GLN L 37  O LYS B 47  ? O LYS L 45  
AA8 5 6 N TYR B 51  ? N TYR L 49  O SER B 55  ? O SER L 53  
AA9 1 2 N LEU B 11  ? N LEU L 11  O GLU B 111 ? O GLU L 105 
AA9 2 3 O THR B 108 ? O THR L 102 N TYR B 88  ? N TYR L 86  
AA9 3 4 N TYR B 94  ? N TYR L 92  O TYR B 101 D O TYR L 95  
AB1 1 2 N PHE B 122 ? N PHE L 116 O LEU B 141 ? O LEU L 135 
AB1 2 3 N ALA B 136 ? N ALA L 130 O LEU B 187 ? O LEU L 181 
AB1 3 4 O THR B 184 ? O THR L 178 N GLN B 166 ? N GLN L 160 
AB2 1 2 O ALA B 159 ? O ALA L 153 N VAL B 156 ? N VAL L 150 
AB2 2 3 N SER B 153 ? N SER L 147 O GLU B 201 ? O GLU L 195 
AB2 3 4 N VAL B 202 ? N VAL L 196 O VAL B 209 ? O VAL L 203 
# 
_pdbx_entry_details.entry_id                   8UHT 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PHE H 27  ? ? -151.57 -152.42 
2  1 ILE H 48  ? ? -98.89  -71.45  
3  1 THR H 68  ? ? -164.45 117.23  
4  1 ASP H 143 ? ? 60.45   65.43   
5  1 PHE H 145 ? ? -170.53 139.85  
6  1 GLN L 27  ? ? -87.05  -139.83 
7  1 TRP L 28  ? ? 66.65   -67.79  
8  1 ILE L 51  ? ? 63.09   -55.61  
9  1 SER L 67  ? ? -154.67 29.42   
10 1 ALA L 84  ? ? -164.77 -167.07 
11 1 SER L 94  ? ? -122.21 -87.34  
12 1 GLU L 95  ? ? -122.43 -75.90  
13 1 ASN L 138 ? ? 56.51   71.74   
14 1 LYS L 169 ? ? -87.79  -71.46  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 H THR 130 ? A THR 134 
2 1 Y 1 H SER 131 ? A SER 135 
3 1 Y 1 H SER 214 ? A SER 218 
4 1 Y 1 H CYS 215 ? A CYS 219 
5 1 Y 1 H ASP 216 ? A ASP 220 
6 1 Y 1 H LYS 217 ? A LYS 221 
7 1 Y 1 H THR 218 ? A THR 222 
8 1 Y 1 H HIS 219 ? A HIS 223 
9 1 Y 1 H THR 220 ? A THR 224 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Cancer Institute (NIH/NCI)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           CA242443 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6X1V 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8UHT 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020103 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013647 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006736 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 1   ? -15.02961 -20.03016 -1.82911  1.000 64.80480  ? 1   GLU H N   1 
ATOM   2    C CA  . GLU A 1 1   ? -15.08234 -21.08961 -0.82786  1.000 62.18786  ? 1   GLU H CA  1 
ATOM   3    C C   . GLU A 1 1   ? -13.78725 -21.15017 -0.02203  1.000 70.93019  ? 1   GLU H C   1 
ATOM   4    O O   . GLU A 1 1   ? -12.72878 -20.72348 -0.48818  1.000 83.08728  ? 1   GLU H O   1 
ATOM   5    C CB  . GLU A 1 1   ? -15.35316 -22.44971 -1.48336  1.000 65.46668  ? 1   GLU H CB  1 
ATOM   6    C CG  . GLU A 1 1   ? -16.61925 -22.51936 -2.34337  1.000 65.63540  ? 1   GLU H CG  1 
ATOM   7    C CD  . GLU A 1 1   ? -17.90964 -22.58006 -1.54263  1.000 57.35970  ? 1   GLU H CD  1 
ATOM   8    O OE1 . GLU A 1 1   ? -17.86348 -22.96605 -0.35311  1.000 55.56802  ? 1   GLU H OE1 1 
ATOM   9    O OE2 . GLU A 1 1   ? -18.97254 -22.24689 -2.11660  1.000 52.19086  ? 1   GLU H OE2 1 
ATOM   10   N N   . VAL A 1 2   ? -13.89065 -21.68980 1.19339   1.000 69.21221  ? 2   VAL H N   1 
ATOM   11   C CA  . VAL A 1 2   ? -12.74068 -21.81179 2.08324   1.000 77.33173  ? 2   VAL H CA  1 
ATOM   12   C C   . VAL A 1 2   ? -11.80191 -22.89762 1.56881   1.000 76.73937  ? 2   VAL H C   1 
ATOM   13   O O   . VAL A 1 2   ? -12.21449 -24.04014 1.32903   1.000 68.85688  ? 2   VAL H O   1 
ATOM   14   C CB  . VAL A 1 2   ? -13.20827 -22.11050 3.51687   1.000 74.95618  ? 2   VAL H CB  1 
ATOM   15   C CG1 . VAL A 1 2   ? -12.01266 -22.29574 4.44800   1.000 60.13379  ? 2   VAL H CG1 1 
ATOM   16   C CG2 . VAL A 1 2   ? -14.12990 -21.00127 4.01692   1.000 57.98983  ? 2   VAL H CG2 1 
ATOM   17   N N   . GLN A 1 3   ? -10.52098 -22.55428 1.41821   1.000 74.83451  ? 3   GLN H N   1 
ATOM   18   C CA  . GLN A 1 3   ? -9.54459  -23.49234 0.89030   1.000 70.08509  ? 3   GLN H CA  1 
ATOM   19   C C   . GLN A 1 3   ? -8.45186  -23.88631 1.87555   1.000 70.13161  ? 3   GLN H C   1 
ATOM   20   O O   . GLN A 1 3   ? -7.66921  -24.78703 1.55905   1.000 73.19972  ? 3   GLN H O   1 
ATOM   21   C CB  . GLN A 1 3   ? -8.90325  -22.92385 -0.38440  1.000 74.69405  ? 3   GLN H CB  1 
ATOM   22   C CG  . GLN A 1 3   ? -9.91940  -22.62156 -1.47888  1.000 75.84235  ? 3   GLN H CG  1 
ATOM   23   C CD  . GLN A 1 3   ? -9.27524  -22.25153 -2.79547  1.000 75.14169  ? 3   GLN H CD  1 
ATOM   24   O OE1 . GLN A 1 3   ? -9.42328  -21.12852 -3.27168  1.000 78.47640  ? 3   GLN H OE1 1 
ATOM   25   N NE2 . GLN A 1 3   ? -8.55715  -23.19637 -3.39369  1.000 70.14818  ? 3   GLN H NE2 1 
ATOM   26   N N   . LEU A 1 4   ? -8.38252  -23.26451 3.05654   1.000 74.84535  ? 4   LEU H N   1 
ATOM   27   C CA  . LEU A 1 4   ? -7.37236  -23.58000 4.06954   1.000 75.82742  ? 4   LEU H CA  1 
ATOM   28   C C   . LEU A 1 4   ? -8.06922  -23.82266 5.40561   1.000 72.06866  ? 4   LEU H C   1 
ATOM   29   O O   . LEU A 1 4   ? -8.62285  -22.88945 5.99515   1.000 75.03032  ? 4   LEU H O   1 
ATOM   30   C CB  . LEU A 1 4   ? -6.34220  -22.45502 4.18600   1.000 72.53342  ? 4   LEU H CB  1 
ATOM   31   C CG  . LEU A 1 4   ? -4.88327  -22.88376 4.29602   1.000 58.74815  ? 4   LEU H CG  1 
ATOM   32   C CD1 . LEU A 1 4   ? -4.51328  -23.75535 3.11598   1.000 63.82130  ? 4   LEU H CD1 1 
ATOM   33   C CD2 . LEU A 1 4   ? -3.95979  -21.67669 4.38345   1.000 68.92842  ? 4   LEU H CD2 1 
ATOM   34   N N   . VAL A 1 5   ? -8.02337  -25.06470 5.89586   1.000 73.38848  ? 5   VAL H N   1 
ATOM   35   C CA  . VAL A 1 5   ? -8.80651  -25.49872 7.05200   1.000 77.39594  ? 5   VAL H CA  1 
ATOM   36   C C   . VAL A 1 5   ? -7.87896  -26.06132 8.12534   1.000 77.95755  ? 5   VAL H C   1 
ATOM   37   O O   . VAL A 1 5   ? -7.09079  -26.97697 7.85580   1.000 75.05620  ? 5   VAL H O   1 
ATOM   38   C CB  . VAL A 1 5   ? -9.85599  -26.55318 6.65721   1.000 74.02139  ? 5   VAL H CB  1 
ATOM   39   C CG1 . VAL A 1 5   ? -10.69975 -26.92730 7.85619   1.000 76.28853  ? 5   VAL H CG1 1 
ATOM   40   C CG2 . VAL A 1 5   ? -10.72646 -26.05161 5.51090   1.000 82.87205  ? 5   VAL H CG2 1 
ATOM   41   N N   . GLU A 1 6   ? -7.99978  -25.53511 9.34659   1.000 71.30183  ? 6   GLU H N   1 
ATOM   42   C CA  . GLU A 1 6   ? -7.27114  -26.03471 10.50767  1.000 71.74837  ? 6   GLU H CA  1 
ATOM   43   C C   . GLU A 1 6   ? -8.12984  -27.02732 11.28002  1.000 63.95017  ? 6   GLU H C   1 
ATOM   44   O O   . GLU A 1 6   ? -9.32359  -26.80001 11.49142  1.000 62.29726  ? 6   GLU H O   1 
ATOM   45   C CB  . GLU A 1 6   ? -6.85775  -24.89985 11.44962  1.000 68.73529  ? 6   GLU H CB  1 
ATOM   46   C CG  . GLU A 1 6   ? -5.76734  -23.97985 10.92696  1.000 68.75224  ? 6   GLU H CG  1 
ATOM   47   C CD  . GLU A 1 6   ? -6.33113  -22.75957 10.23629  1.000 61.74287  ? 6   GLU H CD  1 
ATOM   48   O OE1 . GLU A 1 6   ? -7.48683  -22.83182 9.78169   1.000 69.41101  ? 6   GLU H OE1 1 
ATOM   49   O OE2 . GLU A 1 6   ? -5.63230  -21.72949 10.15210  1.000 56.36133  ? 6   GLU H OE2 1 
ATOM   50   N N   . SER A 1 7   ? -7.50755  -28.11418 11.72406  1.000 66.36186  ? 7   SER H N   1 
ATOM   51   C CA  . SER A 1 7   ? -8.19760  -29.16239 12.45577  1.000 59.78919  ? 7   SER H CA  1 
ATOM   52   C C   . SER A 1 7   ? -7.33481  -29.60026 13.62987  1.000 66.29926  ? 7   SER H C   1 
ATOM   53   O O   . SER A 1 7   ? -6.16076  -29.23328 13.74033  1.000 67.67452  ? 7   SER H O   1 
ATOM   54   C CB  . SER A 1 7   ? -8.51858  -30.34827 11.54186  1.000 65.40072  ? 7   SER H CB  1 
ATOM   55   O OG  . SER A 1 7   ? -7.38963  -30.68501 10.75504  1.000 79.91844  ? 7   SER H OG  1 
ATOM   56   N N   . GLY A 1 8   ? -7.92954  -30.39363 14.51539  1.000 65.93889  ? 8   GLY H N   1 
ATOM   57   C CA  . GLY A 1 8   ? -7.20665  -30.90998 15.65618  1.000 68.25737  ? 8   GLY H CA  1 
ATOM   58   C C   . GLY A 1 8   ? -7.13252  -29.98803 16.85008  1.000 60.40371  ? 8   GLY H C   1 
ATOM   59   O O   . GLY A 1 8   ? -6.36299  -30.26534 17.77732  1.000 68.89631  ? 8   GLY H O   1 
ATOM   60   N N   . GLY A 1 9   ? -7.89115  -28.90082 16.85776  1.000 59.74340  ? 9   GLY H N   1 
ATOM   61   C CA  . GLY A 1 9   ? -7.97743  -28.07176 18.03694  1.000 47.03710  ? 9   GLY H CA  1 
ATOM   62   C C   . GLY A 1 9   ? -8.79593  -28.74044 19.12261  1.000 58.60916  ? 9   GLY H C   1 
ATOM   63   O O   . GLY A 1 9   ? -9.44224  -29.77315 18.92835  1.000 61.44175  ? 9   GLY H O   1 
ATOM   64   N N   . GLY A 1 10  ? -8.76238  -28.12968 20.29304  1.000 54.02544  ? 10  GLY H N   1 
ATOM   65   C CA  . GLY A 1 10  ? -9.47384  -28.63868 21.44567  1.000 47.02913  ? 10  GLY H CA  1 
ATOM   66   C C   . GLY A 1 10  ? -8.75496  -28.23951 22.71887  1.000 49.88829  ? 10  GLY H C   1 
ATOM   67   O O   . GLY A 1 10  ? -7.90192  -27.35247 22.70784  1.000 49.40291  ? 10  GLY H O   1 
ATOM   68   N N   . LEU A 1 11  ? -9.11431  -28.91256 23.81366  1.000 49.02047  ? 11  LEU H N   1 
ATOM   69   C CA  . LEU A 1 11  ? -8.49051  -28.66483 25.10774  1.000 55.21741  ? 11  LEU H CA  1 
ATOM   70   C C   . LEU A 1 11  ? -7.36967  -29.66909 25.35618  1.000 50.32133  ? 11  LEU H C   1 
ATOM   71   O O   . LEU A 1 11  ? -7.46169  -30.83156 24.94928  1.000 42.01649  ? 11  LEU H O   1 
ATOM   72   C CB  . LEU A 1 11  ? -9.52018  -28.73482 26.23743  1.000 46.97990  ? 11  LEU H CB  1 
ATOM   73   C CG  . LEU A 1 11  ? -10.79518 -27.91028 26.07710  1.000 51.84950  ? 11  LEU H CG  1 
ATOM   74   C CD1 . LEU A 1 11  ? -11.96754 -28.82582 25.77907  1.000 43.91858  ? 11  LEU H CD1 1 
ATOM   75   C CD2 . LEU A 1 11  ? -11.06742 -27.05657 27.30856  1.000 46.02158  ? 11  LEU H CD2 1 
ATOM   76   N N   . VAL A 1 12  ? -6.30776  -29.20697 26.01830  1.000 51.25105  ? 12  VAL H N   1 
ATOM   77   C CA  . VAL A 1 12  ? -5.12657  -30.01761 26.31040  1.000 55.34592  ? 12  VAL H CA  1 
ATOM   78   C C   . VAL A 1 12  ? -4.63770  -29.67813 27.71501  1.000 52.82638  ? 12  VAL H C   1 
ATOM   79   O O   . VAL A 1 12  ? -4.48946  -28.49989 28.05861  1.000 51.11273  ? 12  VAL H O   1 
ATOM   80   C CB  . VAL A 1 12  ? -3.99543  -29.78612 25.28326  1.000 51.79943  ? 12  VAL H CB  1 
ATOM   81   C CG1 . VAL A 1 12  ? -2.77636  -30.61323 25.64549  1.000 71.99248  ? 12  VAL H CG1 1 
ATOM   82   C CG2 . VAL A 1 12  ? -4.45176  -30.11469 23.86465  1.000 54.87688  ? 12  VAL H CG2 1 
ATOM   83   N N   . GLN A 1 13  ? -4.37731  -30.70511 28.52360  1.000 55.72344  ? 13  GLN H N   1 
ATOM   84   C CA  . GLN A 1 13  ? -3.86548  -30.47916 29.86991  1.000 64.15501  ? 13  GLN H CA  1 
ATOM   85   C C   . GLN A 1 13  ? -2.40937  -30.02021 29.80353  1.000 60.66346  ? 13  GLN H C   1 
ATOM   86   O O   . GLN A 1 13  ? -1.69202  -30.38221 28.86935  1.000 67.21809  ? 13  GLN H O   1 
ATOM   87   C CB  . GLN A 1 13  ? -3.97410  -31.75461 30.69954  1.000 67.27544  ? 13  GLN H CB  1 
ATOM   88   C CG  . GLN A 1 13  ? -5.38149  -32.33132 30.76038  1.000 66.58299  ? 13  GLN H CG  1 
ATOM   89   C CD  . GLN A 1 13  ? -5.56251  -33.28727 31.92383  1.000 84.20427  ? 13  GLN H CD  1 
ATOM   90   O OE1 . GLN A 1 13  ? -4.61177  -33.94140 32.35017  1.000 97.10995  ? 13  GLN H OE1 1 
ATOM   91   N NE2 . GLN A 1 13  ? -6.78325  -33.36300 32.45427  1.000 91.54799  ? 13  GLN H NE2 1 
ATOM   92   N N   . PRO A 1 14  ? -1.94161  -29.23313 30.78427  1.000 56.00346  ? 14  PRO H N   1 
ATOM   93   C CA  . PRO A 1 14  ? -0.58587  -28.67301 30.68384  1.000 52.57113  ? 14  PRO H CA  1 
ATOM   94   C C   . PRO A 1 14  ? 0.45340   -29.77215 30.53403  1.000 75.50538  ? 14  PRO H C   1 
ATOM   95   O O   . PRO A 1 14  ? 0.25634   -30.90779 30.97778  1.000 71.49672  ? 14  PRO H O   1 
ATOM   96   C CB  . PRO A 1 14  ? -0.40732  -27.90729 32.00170  1.000 46.25627  ? 14  PRO H CB  1 
ATOM   97   C CG  . PRO A 1 14  ? -1.77574  -27.69285 32.51829  1.000 46.77716  ? 14  PRO H CG  1 
ATOM   98   C CD  . PRO A 1 14  ? -2.56686  -28.88933 32.07036  1.000 53.85865  ? 14  PRO H CD  1 
ATOM   99   N N   . GLY A 1 15  ? 1.56188   -29.42711 29.87292  1.000 70.41895  ? 15  GLY H N   1 
ATOM   100  C CA  . GLY A 1 15  ? 2.57256   -30.40172 29.53704  1.000 56.71746  ? 15  GLY H CA  1 
ATOM   101  C C   . GLY A 1 15  ? 2.22589   -31.31388 28.37794  1.000 71.07719  ? 15  GLY H C   1 
ATOM   102  O O   . GLY A 1 15  ? 3.12786   -31.96763 27.83350  1.000 75.16404  ? 15  GLY H O   1 
ATOM   103  N N   . GLY A 1 16  ? 0.95816   -31.38767 27.98261  1.000 84.48526  ? 16  GLY H N   1 
ATOM   104  C CA  . GLY A 1 16  ? 0.55346   -32.14376 26.81581  1.000 70.28810  ? 16  GLY H CA  1 
ATOM   105  C C   . GLY A 1 16  ? 0.98017   -31.45279 25.53077  1.000 67.90650  ? 16  GLY H C   1 
ATOM   106  O O   . GLY A 1 16  ? 1.69366   -30.44779 25.52083  1.000 61.01668  ? 16  GLY H O   1 
ATOM   107  N N   . SER A 1 17  ? 0.51942   -32.01803 24.41838  1.000 66.74639  ? 17  SER H N   1 
ATOM   108  C CA  . SER A 1 17  ? 0.98125   -31.61721 23.09585  1.000 81.81431  ? 17  SER H CA  1 
ATOM   109  C C   . SER A 1 17  ? -0.19309  -31.33650 22.17143  1.000 74.84450  ? 17  SER H C   1 
ATOM   110  O O   . SER A 1 17  ? -1.02965  -32.21812 21.93809  1.000 64.64524  ? 17  SER H O   1 
ATOM   111  C CB  . SER A 1 17  ? 1.87191   -32.70072 22.47716  1.000 84.20725  ? 17  SER H CB  1 
ATOM   112  O OG  . SER A 1 17  ? 3.21951   -32.55679 22.90537  1.000 84.87124  ? 17  SER H OG  1 
ATOM   113  N N   . LEU A 1 18  ? -0.23732  -30.11795 21.62962  1.000 70.91737  ? 18  LEU H N   1 
ATOM   114  C CA  . LEU A 1 18  ? -1.20241  -29.79341 20.58861  1.000 75.41635  ? 18  LEU H CA  1 
ATOM   115  C C   . LEU A 1 18  ? -0.75547  -30.40059 19.26636  1.000 68.83177  ? 18  LEU H C   1 
ATOM   116  O O   . LEU A 1 18  ? 0.43792   -30.45261 18.96058  1.000 75.96257  ? 18  LEU H O   1 
ATOM   117  C CB  . LEU A 1 18  ? -1.36976  -28.27861 20.44985  1.000 52.66349  ? 18  LEU H CB  1 
ATOM   118  C CG  . LEU A 1 18  ? -0.17459  -27.39205 20.09440  1.000 64.03576  ? 18  LEU H CG  1 
ATOM   119  C CD1 . LEU A 1 18  ? 0.11522   -27.34226 18.59046  1.000 66.91256  ? 18  LEU H CD1 1 
ATOM   120  C CD2 . LEU A 1 18  ? -0.41853  -25.99492 20.62019  1.000 63.10598  ? 18  LEU H CD2 1 
ATOM   121  N N   . ARG A 1 19  ? -1.71887  -30.86413 18.48251  1.000 59.54323  ? 19  ARG H N   1 
ATOM   122  C CA  . ARG A 1 19  ? -1.42962  -31.47145 17.18505  1.000 59.81071  ? 19  ARG H CA  1 
ATOM   123  C C   . ARG A 1 19  ? -2.42046  -30.90845 16.16586  1.000 73.26043  ? 19  ARG H C   1 
ATOM   124  O O   . ARG A 1 19  ? -3.48208  -31.48910 15.92393  1.000 75.40927  ? 19  ARG H O   1 
ATOM   125  C CB  . ARG A 1 19  ? -1.49643  -32.98808 17.26245  1.000 61.99821  ? 19  ARG H CB  1 
ATOM   126  C CG  . ARG A 1 19  ? -1.21028  -33.64523 15.93734  1.000 76.16337  ? 19  ARG H CG  1 
ATOM   127  C CD  . ARG A 1 19  ? -1.31736  -35.13908 16.01493  1.000 81.76517  ? 19  ARG H CD  1 
ATOM   128  N NE  . ARG A 1 19  ? -1.03068  -35.72322 14.71338  1.000 89.02531  ? 19  ARG H NE  1 
ATOM   129  C CZ  . ARG A 1 19  ? -1.92390  -35.84317 13.74234  1.000 96.26559  ? 19  ARG H CZ  1 
ATOM   130  N NH1 . ARG A 1 19  ? -3.17548  -35.44276 13.90291  1.000 98.59779  ? 19  ARG H NH1 1 
ATOM   131  N NH2 . ARG A 1 19  ? -1.55292  -36.37809 12.58192  1.000 102.74090 ? 19  ARG H NH2 1 
ATOM   132  N N   . LEU A 1 20  ? -2.06329  -29.77673 15.56721  1.000 67.91772  ? 20  LEU H N   1 
ATOM   133  C CA  . LEU A 1 20  ? -2.91817  -29.09630 14.60457  1.000 61.45346  ? 20  LEU H CA  1 
ATOM   134  C C   . LEU A 1 20  ? -2.46081  -29.39880 13.18855  1.000 71.68465  ? 20  LEU H C   1 
ATOM   135  O O   . LEU A 1 20  ? -1.26070  -29.52371 12.92339  1.000 74.74059  ? 20  LEU H O   1 
ATOM   136  C CB  . LEU A 1 20  ? -2.90282  -27.58841 14.82291  1.000 59.02077  ? 20  LEU H CB  1 
ATOM   137  C CG  . LEU A 1 20  ? -3.06948  -27.19316 16.27932  1.000 54.61021  ? 20  LEU H CG  1 
ATOM   138  C CD1 . LEU A 1 20  ? -2.68448  -25.75301 16.44484  1.000 45.35540  ? 20  LEU H CD1 1 
ATOM   139  C CD2 . LEU A 1 20  ? -4.50042  -27.44002 16.71582  1.000 60.57022  ? 20  LEU H CD2 1 
ATOM   140  N N   . SER A 1 21  ? -3.42175  -29.48531 12.27498  1.000 64.17166  ? 21  SER H N   1 
ATOM   141  C CA  . SER A 1 21  ? -3.14493  -29.88409 10.90497  1.000 72.17275  ? 21  SER H CA  1 
ATOM   142  C C   . SER A 1 21  ? -3.89421  -28.97088 9.94914   1.000 83.65362  ? 21  SER H C   1 
ATOM   143  O O   . SER A 1 21  ? -5.13036  -28.97901 9.91280   1.000 70.61123  ? 21  SER H O   1 
ATOM   144  C CB  . SER A 1 21  ? -3.54088  -31.34167 10.67634  1.000 73.09233  ? 21  SER H CB  1 
ATOM   145  O OG  . SER A 1 21  ? -4.94097  -31.49152 10.81044  1.000 74.56549  ? 21  SER H OG  1 
ATOM   146  N N   . CYS A 1 22  ? -3.13775  -28.18594 9.19041   1.000 79.80819  ? 22  CYS H N   1 
ATOM   147  C CA  . CYS A 1 22  ? -3.67222  -27.40326 8.09048   1.000 72.50019  ? 22  CYS H CA  1 
ATOM   148  C C   . CYS A 1 22  ? -4.03361  -28.31761 6.92330   1.000 71.84303  ? 22  CYS H C   1 
ATOM   149  O O   . CYS A 1 22  ? -3.36159  -29.31428 6.66321   1.000 83.44733  ? 22  CYS H O   1 
ATOM   150  C CB  . CYS A 1 22  ? -2.62813  -26.38010 7.66354   1.000 69.56436  ? 22  CYS H CB  1 
ATOM   151  S SG  . CYS A 1 22  ? -3.18325  -24.98644 6.71278   1.000 71.13836  ? 22  CYS H SG  1 
ATOM   152  N N   . THR A 1 23  ? -5.11253  -27.97868 6.22093   1.000 76.47489  ? 23  THR H N   1 
ATOM   153  C CA  . THR A 1 23  ? -5.61573  -28.79686 5.12131   1.000 76.48087  ? 23  THR H CA  1 
ATOM   154  C C   . THR A 1 23  ? -6.00242  -27.88661 3.96798   1.000 76.47833  ? 23  THR H C   1 
ATOM   155  O O   . THR A 1 23  ? -6.73184  -26.91463 4.17514   1.000 82.56623  ? 23  THR H O   1 
ATOM   156  C CB  . THR A 1 23  ? -6.83513  -29.62131 5.55373   1.000 77.12341  ? 23  THR H CB  1 
ATOM   157  O OG1 . THR A 1 23  ? -6.55073  -30.29390 6.78480   1.000 88.93780  ? 23  THR H OG1 1 
ATOM   158  C CG2 . THR A 1 23  ? -7.19747  -30.64848 4.49126   1.000 72.79880  ? 23  THR H CG2 1 
ATOM   159  N N   . ALA A 1 24  ? -5.53667  -28.19971 2.76087   1.000 77.90734  ? 24  ALA H N   1 
ATOM   160  C CA  . ALA A 1 24  ? -5.85220  -27.40643 1.57928   1.000 77.62818  ? 24  ALA H CA  1 
ATOM   161  C C   . ALA A 1 24  ? -6.84107  -28.13998 0.67900   1.000 74.02330  ? 24  ALA H C   1 
ATOM   162  O O   . ALA A 1 24  ? -6.81567  -29.36818 0.56266   1.000 81.83934  ? 24  ALA H O   1 
ATOM   163  C CB  . ALA A 1 24  ? -4.59015  -27.05874 0.78301   1.000 65.36956  ? 24  ALA H CB  1 
ATOM   164  N N   . SER A 1 25  ? -7.72193  -27.37140 0.04238   1.000 70.43644  ? 25  SER H N   1 
ATOM   165  C CA  . SER A 1 25  ? -8.71918  -27.92355 -0.87114  1.000 87.26275  ? 25  SER H CA  1 
ATOM   166  C C   . SER A 1 25  ? -8.82997  -27.02131 -2.09250  1.000 89.51445  ? 25  SER H C   1 
ATOM   167  O O   . SER A 1 25  ? -9.18533  -25.84427 -1.96902  1.000 82.84599  ? 25  SER H O   1 
ATOM   168  C CB  . SER A 1 25  ? -10.08288 -28.07802 -0.18406  1.000 80.70347  ? 25  SER H CB  1 
ATOM   169  O OG  . SER A 1 25  ? -10.55436 -26.84220 0.33286   1.000 84.10579  ? 25  SER H OG  1 
ATOM   170  N N   . GLY A 1 26  ? -8.52999  -27.57440 -3.26860  1.000 94.03826  ? 26  GLY H N   1 
ATOM   171  C CA  . GLY A 1 26  ? -8.52615  -26.82677 -4.51081  1.000 88.13352  ? 26  GLY H CA  1 
ATOM   172  C C   . GLY A 1 26  ? -7.15121  -26.57369 -5.09074  1.000 90.65722  ? 26  GLY H C   1 
ATOM   173  O O   . GLY A 1 26  ? -7.05871  -26.11299 -6.23538  1.000 101.09851 ? 26  GLY H O   1 
ATOM   174  N N   . PHE A 1 27  ? -6.08209  -26.84914 -4.34424  1.000 83.18152  ? 27  PHE H N   1 
ATOM   175  C CA  . PHE A 1 27  ? -4.72472  -26.69527 -4.85785  1.000 85.68255  ? 27  PHE H CA  1 
ATOM   176  C C   . PHE A 1 27  ? -3.79466  -27.67680 -4.15347  1.000 97.51940  ? 27  PHE H C   1 
ATOM   177  O O   . PHE A 1 27  ? -4.24147  -28.74139 -3.71343  1.000 107.69299 ? 27  PHE H O   1 
ATOM   178  C CB  . PHE A 1 27  ? -4.23535  -25.24660 -4.70829  1.000 78.22265  ? 27  PHE H CB  1 
ATOM   179  C CG  . PHE A 1 27  ? -4.17496  -24.75112 -3.28550  1.000 85.31615  ? 27  PHE H CG  1 
ATOM   180  C CD1 . PHE A 1 27  ? -5.33500  -24.50399 -2.56599  1.000 87.55526  ? 27  PHE H CD1 1 
ATOM   181  C CD2 . PHE A 1 27  ? -2.95526  -24.49233 -2.68209  1.000 80.99792  ? 27  PHE H CD2 1 
ATOM   182  C CE1 . PHE A 1 27  ? -5.27453  -24.03915 -1.26229  1.000 88.55153  ? 27  PHE H CE1 1 
ATOM   183  C CE2 . PHE A 1 27  ? -2.88725  -24.02385 -1.38368  1.000 74.22390  ? 27  PHE H CE2 1 
ATOM   184  C CZ  . PHE A 1 27  ? -4.04707  -23.79691 -0.67212  1.000 83.52861  ? 27  PHE H CZ  1 
ATOM   185  N N   . SER A 1 28  ? -2.50805  -27.34712 -4.04440  1.000 84.88770  ? 28  SER H N   1 
ATOM   186  C CA  . SER A 1 28  ? -1.52947  -28.25045 -3.45346  1.000 87.44561  ? 28  SER H CA  1 
ATOM   187  C C   . SER A 1 28  ? -0.78330  -27.55458 -2.32702  1.000 95.47990  ? 28  SER H C   1 
ATOM   188  O O   . SER A 1 28  ? -0.52633  -26.35016 -2.39988  1.000 99.15982  ? 28  SER H O   1 
ATOM   189  C CB  . SER A 1 28  ? -0.53468  -28.73648 -4.50315  1.000 97.63437  ? 28  SER H CB  1 
ATOM   190  O OG  . SER A 1 28  ? -1.19349  -28.97087 -5.73359  1.000 104.64363 ? 28  SER H OG  1 
ATOM   191  N N   . ILE A 1 29  ? -0.43450  -28.31789 -1.28546  1.000 98.14105  ? 29  ILE H N   1 
ATOM   192  C CA  . ILE A 1 29  ? 0.36636   -27.76636 -0.19127  1.000 101.37087 ? 29  ILE H CA  1 
ATOM   193  C C   . ILE A 1 29  ? 1.85985   -27.83389 -0.47924  1.000 95.36413  ? 29  ILE H C   1 
ATOM   194  O O   . ILE A 1 29  ? 2.64975   -27.16735 0.20569   1.000 92.30092  ? 29  ILE H O   1 
ATOM   195  C CB  . ILE A 1 29  ? 0.09354   -28.48073 1.14414   1.000 97.62827  ? 29  ILE H CB  1 
ATOM   196  C CG1 . ILE A 1 29  ? 0.38693   -29.98130 1.02645   1.000 106.03775 ? 29  ILE H CG1 1 
ATOM   197  C CG2 . ILE A 1 29  ? -1.31932  -28.21021 1.62357   1.000 85.18478  ? 29  ILE H CG2 1 
ATOM   198  C CD1 . ILE A 1 29  ? 1.74932   -30.39713 1.59363   1.000 108.36950 ? 29  ILE H CD1 1 
ATOM   199  N N   . ASP A 1 30  ? 2.26995   -28.64618 -1.45091  1.000 91.66399  ? 30  ASP H N   1 
ATOM   200  C CA  . ASP A 1 30  ? 3.66755   -28.70880 -1.84909  1.000 101.53365 ? 30  ASP H CA  1 
ATOM   201  C C   . ASP A 1 30  ? 4.08189   -27.50992 -2.68837  1.000 99.23306  ? 30  ASP H C   1 
ATOM   202  O O   . ASP A 1 30  ? 5.27236   -27.16937 -2.71745  1.000 96.27115  ? 30  ASP H O   1 
ATOM   203  C CB  . ASP A 1 30  ? 3.91726   -29.99594 -2.63158  1.000 100.78992 ? 30  ASP H CB  1 
ATOM   204  C CG  . ASP A 1 30  ? 2.80282   -30.28766 -3.62066  1.000 103.83123 ? 30  ASP H CG  1 
ATOM   205  O OD1 . ASP A 1 30  ? 2.58175   -29.46374 -4.53629  1.000 92.76260  ? 30  ASP H OD1 1 
ATOM   206  O OD2 . ASP A 1 30  ? 2.13246   -31.32945 -3.47248  1.000 109.03359 ? 30  ASP H OD2 1 
ATOM   207  N N   . SER A 1 31  ? 3.12450   -26.86098 -3.35811  1.000 81.73187  ? 31  SER H N   1 
ATOM   208  C CA  . SER A 1 31  ? 3.42629   -25.78493 -4.29119  1.000 79.61582  ? 31  SER H CA  1 
ATOM   209  C C   . SER A 1 31  ? 3.73900   -24.45788 -3.60974  1.000 88.00305  ? 31  SER H C   1 
ATOM   210  O O   . SER A 1 31  ? 4.25161   -23.55202 -4.27541  1.000 84.50574  ? 31  SER H O   1 
ATOM   211  C CB  . SER A 1 31  ? 2.26486   -25.60877 -5.27811  1.000 91.82598  ? 31  SER H CB  1 
ATOM   212  O OG  . SER A 1 31  ? 1.00587   -25.77741 -4.65044  1.000 91.75650  ? 31  SER H OG  1 
ATOM   213  N N   . TYR A 1 32  ? 3.46538   -24.31897 -2.31241  1.000 89.87697  ? 32  TYR H N   1 
ATOM   214  C CA  . TYR A 1 32  ? 3.72173   -23.07505 -1.59896  1.000 77.80768  ? 32  TYR H CA  1 
ATOM   215  C C   . TYR A 1 32  ? 4.24175   -23.39234 -0.20234  1.000 81.38831  ? 32  TYR H C   1 
ATOM   216  O O   . TYR A 1 32  ? 4.06482   -24.50045 0.30970   1.000 76.74000  ? 32  TYR H O   1 
ATOM   217  C CB  . TYR A 1 32  ? 2.45647   -22.20454 -1.51859  1.000 69.80567  ? 32  TYR H CB  1 
ATOM   218  C CG  . TYR A 1 32  ? 1.66338   -22.14210 -2.81108  1.000 81.04903  ? 32  TYR H CG  1 
ATOM   219  C CD1 . TYR A 1 32  ? 2.03580   -21.28466 -3.84424  1.000 87.61742  ? 32  TYR H CD1 1 
ATOM   220  C CD2 . TYR A 1 32  ? 0.54311   -22.94334 -3.00035  1.000 81.37868  ? 32  TYR H CD2 1 
ATOM   221  C CE1 . TYR A 1 32  ? 1.31063   -21.22943 -5.03062  1.000 88.01503  ? 32  TYR H CE1 1 
ATOM   222  C CE2 . TYR A 1 32  ? -0.18794  -22.89369 -4.17923  1.000 84.30803  ? 32  TYR H CE2 1 
ATOM   223  C CZ  . TYR A 1 32  ? 0.19918   -22.03613 -5.19067  1.000 88.16358  ? 32  TYR H CZ  1 
ATOM   224  O OH  . TYR A 1 32  ? -0.52462  -21.98909 -6.36296  1.000 93.37467  ? 32  TYR H OH  1 
ATOM   225  N N   . GLY A 1 33  ? 4.91595   -22.41068 0.39858   1.000 80.03955  ? 33  GLY H N   1 
ATOM   226  C CA  . GLY A 1 33  ? 5.31386   -22.50302 1.79261   1.000 76.39223  ? 33  GLY H CA  1 
ATOM   227  C C   . GLY A 1 33  ? 4.22287   -21.98306 2.71782   1.000 77.85151  ? 33  GLY H C   1 
ATOM   228  O O   . GLY A 1 33  ? 3.43321   -21.11956 2.34709   1.000 80.59786  ? 33  GLY H O   1 
ATOM   229  N N   . PHE A 1 34  ? 4.17796   -22.52248 3.93894   1.000 73.46379  ? 34  PHE H N   1 
ATOM   230  C CA  . PHE A 1 34  ? 3.10112   -22.22137 4.87673   1.000 66.87090  ? 34  PHE H CA  1 
ATOM   231  C C   . PHE A 1 34  ? 3.64276   -21.93307 6.27051   1.000 58.35131  ? 34  PHE H C   1 
ATOM   232  O O   . PHE A 1 34  ? 4.56375   -22.60587 6.74107   1.000 64.68330  ? 34  PHE H O   1 
ATOM   233  C CB  . PHE A 1 34  ? 2.09410   -23.36695 4.93528   1.000 61.07371  ? 34  PHE H CB  1 
ATOM   234  C CG  . PHE A 1 34  ? 1.21246   -23.44665 3.72813   1.000 71.18819  ? 34  PHE H CG  1 
ATOM   235  C CD1 . PHE A 1 34  ? 1.63399   -24.11139 2.59080   1.000 73.80743  ? 34  PHE H CD1 1 
ATOM   236  C CD2 . PHE A 1 34  ? -0.03589  -22.84233 3.72291   1.000 72.88904  ? 34  PHE H CD2 1 
ATOM   237  C CE1 . PHE A 1 34  ? 0.81887   -24.18487 1.47141   1.000 78.86657  ? 34  PHE H CE1 1 
ATOM   238  C CE2 . PHE A 1 34  ? -0.85700  -22.90858 2.60360   1.000 79.05667  ? 34  PHE H CE2 1 
ATOM   239  C CZ  . PHE A 1 34  ? -0.42942  -23.58273 1.47701   1.000 70.65202  ? 34  PHE H CZ  1 
ATOM   240  N N   . SER A 1 35  ? 3.06451   -20.92247 6.92042   1.000 55.76541  ? 35  SER H N   1 
ATOM   241  C CA  . SER A 1 35  ? 3.42514   -20.50490 8.26711   1.000 51.94243  ? 35  SER H CA  1 
ATOM   242  C C   . SER A 1 35  ? 2.36794   -20.95840 9.26320   1.000 59.50141  ? 35  SER H C   1 
ATOM   243  O O   . SER A 1 35  ? 1.21115   -21.19687 8.90928   1.000 55.95303  ? 35  SER H O   1 
ATOM   244  C CB  . SER A 1 35  ? 3.56870   -18.98111 8.36646   1.000 50.54110  ? 35  SER H CB  1 
ATOM   245  O OG  . SER A 1 35  ? 4.56331   -18.47808 7.50194   1.000 66.95615  ? 35  SER H OG  1 
ATOM   246  N N   . TRP A 1 36  ? 2.77526   -21.06368 10.52696  1.000 55.90045  ? 36  TRP H N   1 
ATOM   247  C CA  . TRP A 1 36  ? 1.83550   -21.18085 11.63408  1.000 42.96710  ? 36  TRP H CA  1 
ATOM   248  C C   . TRP A 1 36  ? 1.95164   -19.92467 12.48212  1.000 42.46921  ? 36  TRP H C   1 
ATOM   249  O O   . TRP A 1 36  ? 3.05657   -19.50616 12.83430  1.000 41.74866  ? 36  TRP H O   1 
ATOM   250  C CB  . TRP A 1 36  ? 2.07772   -22.43758 12.46564  1.000 48.54948  ? 36  TRP H CB  1 
ATOM   251  C CG  . TRP A 1 36  ? 1.56484   -23.69902 11.82614  1.000 35.69599  ? 36  TRP H CG  1 
ATOM   252  C CD1 . TRP A 1 36  ? 2.27208   -24.56244 11.04281  1.000 47.52772  ? 36  TRP H CD1 1 
ATOM   253  C CD2 . TRP A 1 36  ? 0.24072   -24.24109 11.92065  1.000 46.49316  ? 36  TRP H CD2 1 
ATOM   254  N NE1 . TRP A 1 36  ? 1.47274   -25.60626 10.64065  1.000 43.48657  ? 36  TRP H NE1 1 
ATOM   255  C CE2 . TRP A 1 36  ? 0.22098   -25.43296 11.16586  1.000 45.55166  ? 36  TRP H CE2 1 
ATOM   256  C CE3 . TRP A 1 36  ? -0.93232  -23.83354 12.56616  1.000 51.17359  ? 36  TRP H CE3 1 
ATOM   257  C CZ2 . TRP A 1 36  ? -0.92279  -26.22132 11.04158  1.000 56.02205  ? 36  TRP H CZ2 1 
ATOM   258  C CZ3 . TRP A 1 36  ? -2.06613  -24.61886 12.44036  1.000 44.31357  ? 36  TRP H CZ3 1 
ATOM   259  C CH2 . TRP A 1 36  ? -2.05217  -25.79799 11.68491  1.000 53.50650  ? 36  TRP H CH2 1 
ATOM   260  N N   . VAL A 1 37  ? 0.81044   -19.31201 12.77213  1.000 50.25215  ? 37  VAL H N   1 
ATOM   261  C CA  . VAL A 1 37  ? 0.72125   -18.07155 13.52608  1.000 50.61913  ? 37  VAL H CA  1 
ATOM   262  C C   . VAL A 1 37  ? -0.34187  -18.27332 14.59785  1.000 47.70445  ? 37  VAL H C   1 
ATOM   263  O O   . VAL A 1 37  ? -1.35019  -18.95238 14.36818  1.000 48.36593  ? 37  VAL H O   1 
ATOM   264  C CB  . VAL A 1 37  ? 0.37304   -16.88296 12.59816  1.000 51.22689  ? 37  VAL H CB  1 
ATOM   265  C CG1 . VAL A 1 37  ? 0.18221   -15.59610 13.38827  1.000 49.55457  ? 37  VAL H CG1 1 
ATOM   266  C CG2 . VAL A 1 37  ? 1.45010   -16.70130 11.53438  1.000 49.68985  ? 37  VAL H CG2 1 
ATOM   267  N N   . ARG A 1 38  ? -0.11598  -17.70898 15.77255  1.000 42.04445  ? 38  ARG H N   1 
ATOM   268  C CA  . ARG A 1 38  ? -1.07187  -17.85729 16.85357  1.000 42.25985  ? 38  ARG H CA  1 
ATOM   269  C C   . ARG A 1 38  ? -1.41990  -16.49479 17.43378  1.000 45.38651  ? 38  ARG H C   1 
ATOM   270  O O   . ARG A 1 38  ? -0.65042  -15.53364 17.33248  1.000 41.97704  ? 38  ARG H O   1 
ATOM   271  C CB  . ARG A 1 38  ? -0.53829  -18.77941 17.95517  1.000 46.88639  ? 38  ARG H CB  1 
ATOM   272  C CG  . ARG A 1 38  ? 0.55424   -18.16305 18.78912  1.000 48.39500  ? 38  ARG H CG  1 
ATOM   273  C CD  . ARG A 1 38  ? 0.99423   -19.09121 19.89513  1.000 54.03593  ? 38  ARG H CD  1 
ATOM   274  N NE  . ARG A 1 38  ? 1.93714   -18.42864 20.78869  1.000 54.68811  ? 38  ARG H NE  1 
ATOM   275  C CZ  . ARG A 1 38  ? 2.50579   -19.01584 21.82909  1.000 51.63758  ? 38  ARG H CZ  1 
ATOM   276  N NH1 . ARG A 1 38  ? 2.26001   -20.28241 22.12278  1.000 54.61098  ? 38  ARG H NH1 1 
ATOM   277  N NH2 . ARG A 1 38  ? 3.34525   -18.31845 22.58739  1.000 54.08603  ? 38  ARG H NH2 1 
ATOM   278  N N   . GLN A 1 39  ? -2.60179  -16.42496 18.04678  1.000 44.70925  ? 39  GLN H N   1 
ATOM   279  C CA  . GLN A 1 39  ? -3.08891  -15.19175 18.65682  1.000 49.92735  ? 39  GLN H CA  1 
ATOM   280  C C   . GLN A 1 39  ? -3.70720  -15.53405 20.00445  1.000 55.54899  ? 39  GLN H C   1 
ATOM   281  O O   . GLN A 1 39  ? -4.72924  -16.22425 20.06508  1.000 42.91812  ? 39  GLN H O   1 
ATOM   282  C CB  . GLN A 1 39  ? -4.10348  -14.48616 17.75796  1.000 43.76388  ? 39  GLN H CB  1 
ATOM   283  C CG  . GLN A 1 39  ? -4.37238  -13.05312 18.18128  1.000 52.41749  ? 39  GLN H CG  1 
ATOM   284  C CD  . GLN A 1 39  ? -5.07758  -12.24222 17.11212  1.000 47.83120  ? 39  GLN H CD  1 
ATOM   285  O OE1 . GLN A 1 39  ? -5.77124  -12.79322 16.26031  1.000 48.01230  ? 39  GLN H OE1 1 
ATOM   286  N NE2 . GLN A 1 39  ? -4.90275  -10.92361 17.15337  1.000 51.10317  ? 39  GLN H NE2 1 
ATOM   287  N N   . ALA A 1 40  ? -3.08189  -15.06423 21.07862  1.000 54.01091  ? 40  ALA H N   1 
ATOM   288  C CA  . ALA A 1 40  ? -3.64530  -15.22712 22.40073  1.000 50.19900  ? 40  ALA H CA  1 
ATOM   289  C C   . ALA A 1 40  ? -4.83986  -14.29106 22.55906  1.000 65.04710  ? 40  ALA H C   1 
ATOM   290  O O   . ALA A 1 40  ? -4.92092  -13.26284 21.88336  1.000 63.22353  ? 40  ALA H O   1 
ATOM   291  C CB  . ALA A 1 40  ? -2.58914  -14.94108 23.46400  1.000 34.96874  ? 40  ALA H CB  1 
ATOM   292  N N   . PRO A 1 41  ? -5.78964  -14.63093 23.43269  1.000 63.14094  ? 41  PRO H N   1 
ATOM   293  C CA  . PRO A 1 41  ? -6.97477  -13.77539 23.59932  1.000 54.11206  ? 41  PRO H CA  1 
ATOM   294  C C   . PRO A 1 41  ? -6.56955  -12.35350 23.94970  1.000 58.70631  ? 41  PRO H C   1 
ATOM   295  O O   . PRO A 1 41  ? -5.78791  -12.12179 24.87587  1.000 61.22499  ? 41  PRO H O   1 
ATOM   296  C CB  . PRO A 1 41  ? -7.73749  -14.45129 24.74234  1.000 52.09018  ? 41  PRO H CB  1 
ATOM   297  C CG  . PRO A 1 41  ? -7.28638  -15.87381 24.69396  1.000 60.47437  ? 41  PRO H CG  1 
ATOM   298  C CD  . PRO A 1 41  ? -5.84376  -15.81480 24.30711  1.000 57.16283  ? 41  PRO H CD  1 
ATOM   299  N N   . GLY A 1 42  ? -7.08277  -11.39951 23.17386  1.000 58.20723  ? 42  GLY H N   1 
ATOM   300  C CA  . GLY A 1 42  ? -6.77626  -10.00078 23.39947  1.000 58.28169  ? 42  GLY H CA  1 
ATOM   301  C C   . GLY A 1 42  ? -5.33536  -9.60226  23.18390  1.000 60.99943  ? 42  GLY H C   1 
ATOM   302  O O   . GLY A 1 42  ? -4.94777  -8.50314  23.59144  1.000 63.20094  ? 42  GLY H O   1 
ATOM   303  N N   . LYS A 1 43  ? -4.52792  -10.45225 22.55592  1.000 61.94489  ? 43  LYS H N   1 
ATOM   304  C CA  . LYS A 1 43  ? -3.12892  -10.15844 22.27741  1.000 59.32547  ? 43  LYS H CA  1 
ATOM   305  C C   . LYS A 1 43  ? -2.88765  -10.07261 20.77243  1.000 60.68826  ? 43  LYS H C   1 
ATOM   306  O O   . LYS A 1 43  ? -3.75229  -10.39462 19.95291  1.000 51.05800  ? 43  LYS H O   1 
ATOM   307  C CB  . LYS A 1 43  ? -2.21328  -11.22086 22.89532  1.000 56.71046  ? 43  LYS H CB  1 
ATOM   308  C CG  . LYS A 1 43  ? -2.27316  -11.30293 24.39755  1.000 48.23076  ? 43  LYS H CG  1 
ATOM   309  C CD  . LYS A 1 43  ? -1.88693  -9.98638  25.03261  1.000 56.55511  ? 43  LYS H CD  1 
ATOM   310  C CE  . LYS A 1 43  ? -2.01446  -10.06518 26.54666  1.000 66.67410  ? 43  LYS H CE  1 
ATOM   311  N NZ  . LYS A 1 43  ? -1.84151  -8.73796  27.19199  1.000 71.88035  ? 43  LYS H NZ  1 
ATOM   312  N N   . GLY A 1 44  ? -1.68189  -9.63807  20.41433  1.000 60.33079  ? 44  GLY H N   1 
ATOM   313  C CA  . GLY A 1 44  ? -1.29892  -9.50128  19.02746  1.000 56.06579  ? 44  GLY H CA  1 
ATOM   314  C C   . GLY A 1 44  ? -1.06047  -10.83946 18.35216  1.000 51.24247  ? 44  GLY H C   1 
ATOM   315  O O   . GLY A 1 44  ? -1.30229  -11.91325 18.90634  1.000 58.89733  ? 44  GLY H O   1 
ATOM   316  N N   . LEU A 1 45  ? -0.58594  -10.75648 17.10978  1.000 50.94385  ? 45  LEU H N   1 
ATOM   317  C CA  . LEU A 1 45  ? -0.24111  -11.93325 16.32216  1.000 47.88702  ? 45  LEU H CA  1 
ATOM   318  C C   . LEU A 1 45  ? 1.20555   -12.30916 16.59085  1.000 39.67159  ? 45  LEU H C   1 
ATOM   319  O O   . LEU A 1 45  ? 2.08045   -11.43620 16.63550  1.000 51.76842  ? 45  LEU H O   1 
ATOM   320  C CB  . LEU A 1 45  ? -0.43819  -11.67394 14.82623  1.000 50.68314  ? 45  LEU H CB  1 
ATOM   321  C CG  . LEU A 1 45  ? -1.86531  -11.46264 14.31945  1.000 44.48584  ? 45  LEU H CG  1 
ATOM   322  C CD1 . LEU A 1 45  ? -1.85813  -10.86240 12.92515  1.000 39.04780  ? 45  LEU H CD1 1 
ATOM   323  C CD2 . LEU A 1 45  ? -2.62457  -12.77520 14.33213  1.000 45.26629  ? 45  LEU H CD2 1 
ATOM   324  N N   . GLU A 1 46  ? 1.45293   -13.60392 16.76758  1.000 40.86453  ? 46  GLU H N   1 
ATOM   325  C CA  . GLU A 1 46  ? 2.78323   -14.12465 17.05334  1.000 48.75422  ? 46  GLU H CA  1 
ATOM   326  C C   . GLU A 1 46  ? 3.12568   -15.22602 16.06615  1.000 46.78663  ? 46  GLU H C   1 
ATOM   327  O O   . GLU A 1 46  ? 2.33607   -16.15623 15.86937  1.000 44.37652  ? 46  GLU H O   1 
ATOM   328  C CB  . GLU A 1 46  ? 2.87441   -14.67975 18.47527  1.000 55.29041  ? 46  GLU H CB  1 
ATOM   329  C CG  . GLU A 1 46  ? 3.35959   -13.69275 19.51066  1.000 70.83888  ? 46  GLU H CG  1 
ATOM   330  C CD  . GLU A 1 46  ? 3.97558   -14.38694 20.71145  1.000 74.44199  ? 46  GLU H CD  1 
ATOM   331  O OE1 . GLU A 1 46  ? 3.88742   -15.63482 20.77864  1.000 74.90281  ? 46  GLU H OE1 1 
ATOM   332  O OE2 . GLU A 1 46  ? 4.54907   -13.68465 21.57440  1.000 68.18611  ? 46  GLU H OE2 1 
ATOM   333  N N   . HIS A 1 47  ? 4.30704   -15.13800 15.46740  1.000 49.76874  ? 47  HIS H N   1 
ATOM   334  C CA  . HIS A 1 47  ? 4.74725   -16.16434 14.54066  1.000 45.79276  ? 47  HIS H CA  1 
ATOM   335  C C   . HIS A 1 47  ? 5.35108   -17.33486 15.30082  1.000 52.69279  ? 47  HIS H C   1 
ATOM   336  O O   . HIS A 1 47  ? 6.09183   -17.14656 16.27027  1.000 62.14971  ? 47  HIS H O   1 
ATOM   337  C CB  . HIS A 1 47  ? 5.76638   -15.61053 13.55068  1.000 46.15178  ? 47  HIS H CB  1 
ATOM   338  C CG  . HIS A 1 47  ? 6.12377   -16.57662 12.46502  1.000 65.81771  ? 47  HIS H CG  1 
ATOM   339  N ND1 . HIS A 1 47  ? 7.39965   -17.07374 12.29414  1.000 63.28595  ? 47  HIS H ND1 1 
ATOM   340  C CD2 . HIS A 1 47  ? 5.36080   -17.15783 11.50855  1.000 59.88431  ? 47  HIS H CD2 1 
ATOM   341  C CE1 . HIS A 1 47  ? 7.40862   -17.91066 11.27185  1.000 61.36336  ? 47  HIS H CE1 1 
ATOM   342  N NE2 . HIS A 1 47  ? 6.18403   -17.98087 10.77951  1.000 65.44952  ? 47  HIS H NE2 1 
ATOM   343  N N   . ILE A 1 48  ? 5.03451   -18.54674 14.84672  1.000 53.71459  ? 48  ILE H N   1 
ATOM   344  C CA  . ILE A 1 48  ? 5.56845   -19.77010 15.43525  1.000 58.07082  ? 48  ILE H CA  1 
ATOM   345  C C   . ILE A 1 48  ? 6.73400   -20.25150 14.58663  1.000 59.68927  ? 48  ILE H C   1 
ATOM   346  O O   . ILE A 1 48  ? 7.89390   -20.17350 15.00308  1.000 67.54411  ? 48  ILE H O   1 
ATOM   347  C CB  . ILE A 1 48  ? 4.48665   -20.85693 15.53823  1.000 62.14462  ? 48  ILE H CB  1 
ATOM   348  C CG1 . ILE A 1 48  ? 3.29413   -20.35082 16.34665  1.000 55.25318  ? 48  ILE H CG1 1 
ATOM   349  C CG2 . ILE A 1 48  ? 5.06116   -22.11272 16.15536  1.000 61.30884  ? 48  ILE H CG2 1 
ATOM   350  C CD1 . ILE A 1 48  ? 2.18529   -21.35574 16.44295  1.000 45.58672  ? 48  ILE H CD1 1 
ATOM   351  N N   . GLY A 1 49  ? 6.42410   -20.75542 13.39624  1.000 64.33276  ? 49  GLY H N   1 
ATOM   352  C CA  . GLY A 1 49  ? 7.41871   -21.13332 12.40723  1.000 58.32639  ? 49  GLY H CA  1 
ATOM   353  C C   . GLY A 1 49  ? 6.74464   -21.30338 11.06163  1.000 68.23042  ? 49  GLY H C   1 
ATOM   354  O O   . GLY A 1 49  ? 5.52303   -21.17651 10.93661  1.000 65.38484  ? 49  GLY H O   1 
ATOM   355  N N   . TYR A 1 50  ? 7.55457   -21.59258 10.03969  1.000 72.37300  ? 50  TYR H N   1 
ATOM   356  C CA  . TYR A 1 50  ? 7.01589   -21.87178 8.71099   1.000 70.38824  ? 50  TYR H CA  1 
ATOM   357  C C   . TYR A 1 50  ? 7.81119   -22.97830 8.03537   1.000 69.97058  ? 50  TYR H C   1 
ATOM   358  O O   . TYR A 1 50  ? 8.94564   -23.28266 8.40953   1.000 70.00233  ? 50  TYR H O   1 
ATOM   359  C CB  . TYR A 1 50  ? 6.99497   -20.62925 7.80689   1.000 67.77106  ? 50  TYR H CB  1 
ATOM   360  C CG  . TYR A 1 50  ? 8.32750   -20.18695 7.22874   1.000 57.92122  ? 50  TYR H CG  1 
ATOM   361  C CD1 . TYR A 1 50  ? 8.77645   -20.67049 6.00072   1.000 70.14640  ? 50  TYR H CD1 1 
ATOM   362  C CD2 . TYR A 1 50  ? 9.11003   -19.24836 7.88527   1.000 57.15752  ? 50  TYR H CD2 1 
ATOM   363  C CE1 . TYR A 1 50  ? 9.98182   -20.25263 5.45957   1.000 60.90558  ? 50  TYR H CE1 1 
ATOM   364  C CE2 . TYR A 1 50  ? 10.31260  -18.82075 7.35046   1.000 71.61794  ? 50  TYR H CE2 1 
ATOM   365  C CZ  . TYR A 1 50  ? 10.74393  -19.32628 6.14078   1.000 64.57212  ? 50  TYR H CZ  1 
ATOM   366  O OH  . TYR A 1 50  ? 11.94238  -18.89739 5.62130   1.000 79.98193  ? 50  TYR H OH  1 
ATOM   367  N N   . LEU A 1 51  ? 7.19138   -23.57353 7.02221   1.000 55.04846  ? 51  LEU H N   1 
ATOM   368  C CA  . LEU A 1 51  ? 7.78842   -24.64418 6.23786   1.000 69.15367  ? 51  LEU H CA  1 
ATOM   369  C C   . LEU A 1 51  ? 7.82426   -24.21127 4.77746   1.000 82.76498  ? 51  LEU H C   1 
ATOM   370  O O   . LEU A 1 51  ? 6.77533   -23.92286 4.19023   1.000 77.09638  ? 51  LEU H O   1 
ATOM   371  C CB  . LEU A 1 51  ? 6.99506   -25.94259 6.41105   1.000 72.41366  ? 51  LEU H CB  1 
ATOM   372  C CG  . LEU A 1 51  ? 7.48705   -27.21273 5.71065   1.000 78.22205  ? 51  LEU H CG  1 
ATOM   373  C CD1 . LEU A 1 51  ? 8.88765   -27.58329 6.17484   1.000 81.82315  ? 51  LEU H CD1 1 
ATOM   374  C CD2 . LEU A 1 51  ? 6.52747   -28.35879 5.95342   1.000 75.43974  ? 51  LEU H CD2 1 
ATOM   375  N N   . THR A 1 52  ? 9.02816   -24.16272 4.19989   1.000 85.64345  ? 52  THR H N   1 
ATOM   376  C CA  . THR A 1 52  ? 9.20819   -23.75147 2.81100   1.000 80.78561  ? 52  THR H CA  1 
ATOM   377  C C   . THR A 1 52  ? 8.46243   -24.68756 1.86267   1.000 80.78627  ? 52  THR H C   1 
ATOM   378  O O   . THR A 1 52  ? 8.18268   -25.84719 2.18001   1.000 80.76895  ? 52  THR H O   1 
ATOM   379  C CB  . THR A 1 52  ? 10.69021  -23.74536 2.43249   1.000 68.53484  ? 52  THR H CB  1 
ATOM   380  O OG1 . THR A 1 52  ? 11.16384  -25.09432 2.36514   1.000 69.96715  ? 52  THR H OG1 1 
ATOM   381  C CG2 . THR A 1 52  ? 11.51668  -22.97773 3.45687   1.000 76.72831  ? 52  THR H CG2 1 
ATOM   382  N N   . ALA A 1 53  ? 8.14520   -24.16981 0.67149   1.000 85.02676  ? 53  ALA H N   1 
ATOM   383  C CA  . ALA A 1 53  ? 7.56000   -25.02065 -0.35942  1.000 88.75864  ? 53  ALA H CA  1 
ATOM   384  C C   . ALA A 1 53  ? 8.48909   -26.16425 -0.74345  1.000 95.59370  ? 53  ALA H C   1 
ATOM   385  O O   . ALA A 1 53  ? 8.02622   -27.15743 -1.31775  1.000 88.23856  ? 53  ALA H O   1 
ATOM   386  C CB  . ALA A 1 53  ? 7.20354   -24.19972 -1.59757  1.000 82.09775  ? 53  ALA H CB  1 
ATOM   387  N N   . GLY A 1 54  ? 9.78498   -26.04069 -0.44674  1.000 87.19279  ? 54  GLY H N   1 
ATOM   388  C CA  . GLY A 1 54  ? 10.71459  -27.14271 -0.58440  1.000 89.31320  ? 54  GLY H CA  1 
ATOM   389  C C   . GLY A 1 54  ? 10.49682  -28.20320 0.47663   1.000 103.40569 ? 54  GLY H C   1 
ATOM   390  O O   . GLY A 1 54  ? 9.90741   -29.25266 0.19434   1.000 100.54377 ? 54  GLY H O   1 
ATOM   391  N N   . GLY A 1 55  ? 10.95819  -27.94345 1.70285   1.000 95.07030  ? 55  GLY H N   1 
ATOM   392  C CA  . GLY A 1 55  ? 10.74223  -28.87939 2.78965   1.000 68.73076  ? 55  GLY H CA  1 
ATOM   393  C C   . GLY A 1 55  ? 11.52884  -28.60947 4.05461   1.000 76.69188  ? 55  GLY H C   1 
ATOM   394  O O   . GLY A 1 55  ? 11.50093  -29.42810 4.97574   1.000 82.02720  ? 55  GLY H O   1 
ATOM   395  N N   . ARG A 1 56  ? 12.23897  -27.48284 4.12338   1.000 87.52116  ? 56  ARG H N   1 
ATOM   396  C CA  . ARG A 1 56  ? 12.97253  -27.11234 5.33124   1.000 82.34205  ? 56  ARG H CA  1 
ATOM   397  C C   . ARG A 1 56  ? 12.09446  -26.24504 6.22717   1.000 86.44516  ? 56  ARG H C   1 
ATOM   398  O O   . ARG A 1 56  ? 11.47426  -25.28042 5.76481   1.000 79.08719  ? 56  ARG H O   1 
ATOM   399  C CB  . ARG A 1 56  ? 14.27730  -26.37646 5.00422   1.000 76.97094  ? 56  ARG H CB  1 
ATOM   400  C CG  . ARG A 1 56  ? 15.07029  -25.96921 6.25792   1.000 75.59304  ? 56  ARG H CG  1 
ATOM   401  C CD  . ARG A 1 56  ? 16.43887  -25.36022 5.94170   1.000 83.19728  ? 56  ARG H CD  1 
ATOM   402  N NE  . ARG A 1 56  ? 17.16764  -24.98027 7.15083   1.000 85.67903  ? 56  ARG H NE  1 
ATOM   403  C CZ  . ARG A 1 56  ? 18.39284  -24.46543 7.16729   1.000 89.63316  ? 56  ARG H CZ  1 
ATOM   404  N NH1 . ARG A 1 56  ? 19.07014  -24.25201 6.05071   1.000 88.45723  ? 56  ARG H NH1 1 
ATOM   405  N NH2 . ARG A 1 56  ? 18.95309  -24.15617 8.33445   1.000 88.69283  ? 56  ARG H NH2 1 
ATOM   406  N N   . ALA A 1 57  ? 12.04509  -26.59303 7.50680   1.000 78.83778  ? 57  ALA H N   1 
ATOM   407  C CA  . ALA A 1 57  ? 11.21969  -25.88867 8.47288   1.000 72.13613  ? 57  ALA H CA  1 
ATOM   408  C C   . ALA A 1 57  ? 12.08953  -24.99576 9.34479   1.000 65.19212  ? 57  ALA H C   1 
ATOM   409  O O   . ALA A 1 57  ? 13.16734  -25.40584 9.78871   1.000 63.72269  ? 57  ALA H O   1 
ATOM   410  C CB  . ALA A 1 57  ? 10.43316  -26.87156 9.33849   1.000 78.79465  ? 57  ALA H CB  1 
ATOM   411  N N   . PHE A 1 58  ? 11.61411  -23.77701 9.57858   1.000 70.22262  ? 58  PHE H N   1 
ATOM   412  C CA  . PHE A 1 58  ? 12.27633  -22.78970 10.41763  1.000 77.79627  ? 58  PHE H CA  1 
ATOM   413  C C   . PHE A 1 58  ? 11.34065  -22.40252 11.55199  1.000 75.61642  ? 58  PHE H C   1 
ATOM   414  O O   . PHE A 1 58  ? 10.12811  -22.28189 11.34828  1.000 72.22962  ? 58  PHE H O   1 
ATOM   415  C CB  . PHE A 1 58  ? 12.65457  -21.53476 9.61607   1.000 83.02103  ? 58  PHE H CB  1 
ATOM   416  C CG  . PHE A 1 58  ? 13.90557  -21.68004 8.79368   1.000 88.64334  ? 58  PHE H CG  1 
ATOM   417  C CD1 . PHE A 1 58  ? 15.13524  -21.32294 9.32228   1.000 80.53704  ? 58  PHE H CD1 1 
ATOM   418  C CD2 . PHE A 1 58  ? 13.84923  -22.15457 7.48703   1.000 80.19378  ? 58  PHE H CD2 1 
ATOM   419  C CE1 . PHE A 1 58  ? 16.28356  -21.44335 8.57228   1.000 94.65216  ? 58  PHE H CE1 1 
ATOM   420  C CE2 . PHE A 1 58  ? 14.99733  -22.28126 6.73076   1.000 71.03343  ? 58  PHE H CE2 1 
ATOM   421  C CZ  . PHE A 1 58  ? 16.21606  -21.92363 7.27242   1.000 88.42781  ? 58  PHE H CZ  1 
ATOM   422  N N   . TYR A 1 59  ? 11.90643  -22.18719 12.73824  1.000 70.67050  ? 59  TYR H N   1 
ATOM   423  C CA  . TYR A 1 59  ? 11.12534  -21.87207 13.92252  1.000 66.05524  ? 59  TYR H CA  1 
ATOM   424  C C   . TYR A 1 59  ? 11.62845  -20.56995 14.53266  1.000 70.88417  ? 59  TYR H C   1 
ATOM   425  O O   . TYR A 1 59  ? 12.75462  -20.13496 14.28172  1.000 74.99337  ? 59  TYR H O   1 
ATOM   426  C CB  . TYR A 1 59  ? 11.18306  -23.02462 14.94396  1.000 62.58325  ? 59  TYR H CB  1 
ATOM   427  C CG  . TYR A 1 59  ? 10.73471  -24.35940 14.37624  1.000 63.85848  ? 59  TYR H CG  1 
ATOM   428  C CD1 . TYR A 1 59  ? 9.40514   -24.74974 14.42897  1.000 58.76915  ? 59  TYR H CD1 1 
ATOM   429  C CD2 . TYR A 1 59  ? 11.63978  -25.22218 13.77613  1.000 55.30774  ? 59  TYR H CD2 1 
ATOM   430  C CE1 . TYR A 1 59  ? 8.99052   -25.96882 13.90211  1.000 61.89412  ? 59  TYR H CE1 1 
ATOM   431  C CE2 . TYR A 1 59  ? 11.23533  -26.44165 13.24811  1.000 55.76500  ? 59  TYR H CE2 1 
ATOM   432  C CZ  . TYR A 1 59  ? 9.91108   -26.81216 13.31234  1.000 69.84867  ? 59  TYR H CZ  1 
ATOM   433  O OH  . TYR A 1 59  ? 9.51145   -28.02403 12.78128  1.000 66.22240  ? 59  TYR H OH  1 
ATOM   434  N N   . ALA A 1 60  ? 10.76200  -19.92678 15.31156  1.000 74.22082  ? 60  ALA H N   1 
ATOM   435  C CA  . ALA A 1 60  ? 11.15070  -18.73479 16.04716  1.000 70.58251  ? 60  ALA H CA  1 
ATOM   436  C C   . ALA A 1 60  ? 11.84831  -19.13639 17.34600  1.000 69.58846  ? 60  ALA H C   1 
ATOM   437  O O   . ALA A 1 60  ? 11.93416  -20.31539 17.69889  1.000 67.90346  ? 60  ALA H O   1 
ATOM   438  C CB  . ALA A 1 60  ? 9.93535   -17.85058 16.31256  1.000 69.64313  ? 60  ALA H CB  1 
ATOM   439  N N   . SER A 1 61  ? 12.35736  -18.13806 18.07043  1.000 81.73884  ? 61  SER H N   1 
ATOM   440  C CA  . SER A 1 61  ? 13.14043  -18.41223 19.27351  1.000 83.27021  ? 61  SER H CA  1 
ATOM   441  C C   . SER A 1 61  ? 12.33069  -19.19739 20.30030  1.000 87.23951  ? 61  SER H C   1 
ATOM   442  O O   . SER A 1 61  ? 12.74964  -20.27286 20.74566  1.000 85.22151  ? 61  SER H O   1 
ATOM   443  C CB  . SER A 1 61  ? 13.64102  -17.10226 19.88079  1.000 86.16687  ? 61  SER H CB  1 
ATOM   444  O OG  . SER A 1 61  ? 12.55028  -16.35456 20.39782  1.000 99.22839  ? 61  SER H OG  1 
ATOM   445  N N   . TRP A 1 62  ? 11.16554  -18.67156 20.69322  1.000 79.76670  ? 62  TRP H N   1 
ATOM   446  C CA  . TRP A 1 62  ? 10.36712  -19.34687 21.71031  1.000 68.95013  ? 62  TRP H CA  1 
ATOM   447  C C   . TRP A 1 62  ? 9.91202   -20.71935 21.22960  1.000 69.30289  ? 62  TRP H C   1 
ATOM   448  O O   . TRP A 1 62  ? 9.97795   -21.70167 21.97816  1.000 74.61184  ? 62  TRP H O   1 
ATOM   449  C CB  . TRP A 1 62  ? 9.17159   -18.47602 22.11281  1.000 72.95266  ? 62  TRP H CB  1 
ATOM   450  C CG  . TRP A 1 62  ? 8.17424   -18.18359 21.01999  1.000 79.65544  ? 62  TRP H CG  1 
ATOM   451  C CD1 . TRP A 1 62  ? 8.18637   -17.12185 20.15652  1.000 68.06072  ? 62  TRP H CD1 1 
ATOM   452  C CD2 . TRP A 1 62  ? 7.00243   -18.94687 20.69788  1.000 75.06657  ? 62  TRP H CD2 1 
ATOM   453  N NE1 . TRP A 1 62  ? 7.10527   -17.18589 19.31238  1.000 64.82849  ? 62  TRP H NE1 1 
ATOM   454  C CE2 . TRP A 1 62  ? 6.36381   -18.29651 19.62209  1.000 69.12239  ? 62  TRP H CE2 1 
ATOM   455  C CE3 . TRP A 1 62  ? 6.43646   -20.12165 21.20882  1.000 71.00832  ? 62  TRP H CE3 1 
ATOM   456  C CZ2 . TRP A 1 62  ? 5.19060   -18.78119 19.04856  1.000 62.07714  ? 62  TRP H CZ2 1 
ATOM   457  C CZ3 . TRP A 1 62  ? 5.27036   -20.60307 20.63491  1.000 67.89549  ? 62  TRP H CZ3 1 
ATOM   458  C CH2 . TRP A 1 62  ? 4.66314   -19.93376 19.56552  1.000 68.43411  ? 62  TRP H CH2 1 
ATOM   459  N N   . ALA A 1 63  ? 9.47517   -20.81263 19.97865  1.000 67.09691  ? 63  ALA H N   1 
ATOM   460  C CA  . ALA A 1 63  ? 8.95021   -22.05806 19.44302  1.000 61.60380  ? 63  ALA H CA  1 
ATOM   461  C C   . ALA A 1 63  ? 10.03261  -23.07142 19.10083  1.000 70.81385  ? 63  ALA H C   1 
ATOM   462  O O   . ALA A 1 63  ? 9.70694   -24.24897 18.91107  1.000 75.92023  ? 63  ALA H O   1 
ATOM   463  C CB  . ALA A 1 63  ? 8.11019   -21.76778 18.19873  1.000 72.38025  ? 63  ALA H CB  1 
ATOM   464  N N   . LYS A 1 64  ? 11.29815  -22.64755 19.00496  1.000 86.16769  ? 64  LYS H N   1 
ATOM   465  C CA  . LYS A 1 64  ? 12.36853  -23.56663 18.61870  1.000 85.39081  ? 64  LYS H CA  1 
ATOM   466  C C   . LYS A 1 64  ? 12.40959  -24.76794 19.55632  1.000 74.75960  ? 64  LYS H C   1 
ATOM   467  O O   . LYS A 1 64  ? 12.24868  -25.91994 19.12529  1.000 63.61599  ? 64  LYS H O   1 
ATOM   468  C CB  . LYS A 1 64  ? 13.71481  -22.82594 18.61336  1.000 73.56542  ? 64  LYS H CB  1 
ATOM   469  C CG  . LYS A 1 64  ? 14.77925  -23.38284 17.64503  1.000 77.17053  ? 64  LYS H CG  1 
ATOM   470  C CD  . LYS A 1 64  ? 16.07737  -22.55900 17.69745  1.000 77.20521  ? 64  LYS H CD  1 
ATOM   471  C CE  . LYS A 1 64  ? 17.14601  -23.07650 16.72516  1.000 75.85960  ? 64  LYS H CE  1 
ATOM   472  N NZ  . LYS A 1 64  ? 18.40154  -22.25125 16.72959  1.000 58.09097  ? 64  LYS H NZ  1 
ATOM   473  N N   . SER A 1 65  ? 12.56374  -24.49916 20.85772  1.000 62.43958  ? 65  SER H N   1 
ATOM   474  C CA  . SER A 1 65  ? 12.71241  -25.53438 21.87371  1.000 61.03410  ? 65  SER H CA  1 
ATOM   475  C C   . SER A 1 65  ? 11.59802  -26.58120 21.84344  1.000 70.37859  ? 65  SER H C   1 
ATOM   476  O O   . SER A 1 65  ? 11.83734  -27.72721 22.24263  1.000 62.22979  ? 65  SER H O   1 
ATOM   477  C CB  . SER A 1 65  ? 12.78867  -24.85643 23.24717  1.000 54.24207  ? 65  SER H CB  1 
ATOM   478  O OG  . SER A 1 65  ? 12.13290  -25.60763 24.25151  1.000 67.12333  ? 65  SER H OG  1 
ATOM   479  N N   . ARG A 1 66  ? 10.40336  -26.23340 21.34876  1.000 63.55880  ? 66  ARG H N   1 
ATOM   480  C CA  . ARG A 1 66  ? 9.22201   -27.05780 21.59287  1.000 68.03138  ? 66  ARG H CA  1 
ATOM   481  C C   . ARG A 1 66  ? 8.45688   -27.48952 20.34177  1.000 70.33737  ? 66  ARG H C   1 
ATOM   482  O O   . ARG A 1 66  ? 7.80982   -28.54165 20.35259  1.000 70.88703  ? 66  ARG H O   1 
ATOM   483  C CB  . ARG A 1 66  ? 8.26895   -26.31058 22.53582  1.000 73.07831  ? 66  ARG H CB  1 
ATOM   484  C CG  . ARG A 1 66  ? 8.99423   -25.47860 23.58169  1.000 70.53935  ? 66  ARG H CG  1 
ATOM   485  C CD  . ARG A 1 66  ? 8.13116   -25.12269 24.77156  1.000 71.60384  ? 66  ARG H CD  1 
ATOM   486  N NE  . ARG A 1 66  ? 7.40509   -23.86586 24.62333  1.000 81.97312  ? 66  ARG H NE  1 
ATOM   487  C CZ  . ARG A 1 66  ? 6.09614   -23.78223 24.42488  1.000 83.97437  ? 66  ARG H CZ  1 
ATOM   488  N NH1 . ARG A 1 66  ? 5.35595   -24.86724 24.24567  1.000 66.75497  ? 66  ARG H NH1 1 
ATOM   489  N NH2 . ARG A 1 66  ? 5.51384   -22.58286 24.42099  1.000 66.09538  ? 66  ARG H NH2 1 
ATOM   490  N N   . SER A 1 67  ? 8.51299   -26.70883 19.26456  1.000 74.96303  ? 67  SER H N   1 
ATOM   491  C CA  . SER A 1 67  ? 7.59654   -26.90019 18.14529  1.000 73.67659  ? 67  SER H CA  1 
ATOM   492  C C   . SER A 1 67  ? 8.17056   -27.84154 17.08297  1.000 70.85002  ? 67  SER H C   1 
ATOM   493  O O   . SER A 1 67  ? 9.34214   -28.21769 17.11223  1.000 83.86865  ? 67  SER H O   1 
ATOM   494  C CB  . SER A 1 67  ? 7.24743   -25.55222 17.51962  1.000 71.64375  ? 67  SER H CB  1 
ATOM   495  O OG  . SER A 1 67  ? 7.03228   -24.58007 18.52817  1.000 60.58146  ? 67  SER H OG  1 
ATOM   496  N N   . THR A 1 68  ? 7.31840   -28.20944 16.12275  1.000 71.56686  ? 68  THR H N   1 
ATOM   497  C CA  . THR A 1 68  ? 7.68865   -29.13262 15.04709  1.000 66.19001  ? 68  THR H CA  1 
ATOM   498  C C   . THR A 1 68  ? 6.65734   -29.04733 13.92899  1.000 75.48592  ? 68  THR H C   1 
ATOM   499  O O   . THR A 1 68  ? 5.48977   -29.39198 14.14586  1.000 75.28693  ? 68  THR H O   1 
ATOM   500  C CB  . THR A 1 68  ? 7.78097   -30.56416 15.56812  1.000 67.25963  ? 68  THR H CB  1 
ATOM   501  O OG1 . THR A 1 68  ? 8.95523   -30.70212 16.37558  1.000 78.37040  ? 68  THR H OG1 1 
ATOM   502  C CG2 . THR A 1 68  ? 7.83506   -31.56016 14.40766  1.000 62.65222  ? 68  THR H CG2 1 
ATOM   503  N N   . ILE A 1 69  ? 7.08072   -28.62251 12.73384  1.000 75.35509  ? 69  ILE H N   1 
ATOM   504  C CA  . ILE A 1 69  ? 6.19163   -28.48358 11.57482  1.000 68.49392  ? 69  ILE H CA  1 
ATOM   505  C C   . ILE A 1 69  ? 6.60391   -29.49224 10.51461  1.000 66.76545  ? 69  ILE H C   1 
ATOM   506  O O   . ILE A 1 69  ? 7.74923   -29.48069 10.05084  1.000 82.62235  ? 69  ILE H O   1 
ATOM   507  C CB  . ILE A 1 69  ? 6.21304   -27.06774 10.97500  1.000 58.20336  ? 69  ILE H CB  1 
ATOM   508  C CG1 . ILE A 1 69  ? 5.83725   -26.01669 12.01071  1.000 54.15192  ? 69  ILE H CG1 1 
ATOM   509  C CG2 . ILE A 1 69  ? 5.25438   -26.98372 9.79790   1.000 63.92455  ? 69  ILE H CG2 1 
ATOM   510  C CD1 . ILE A 1 69  ? 5.88726   -24.62438 11.46401  1.000 58.66195  ? 69  ILE H CD1 1 
ATOM   511  N N   . THR A 1 70  ? 5.66644   -30.33633 10.10857  1.000 62.82243  ? 70  THR H N   1 
ATOM   512  C CA  . THR A 1 70  ? 5.87205   -31.31210 9.05347   1.000 61.64407  ? 70  THR H CA  1 
ATOM   513  C C   . THR A 1 70  ? 4.70431   -31.20728 8.08684   1.000 76.89770  ? 70  THR H C   1 
ATOM   514  O O   . THR A 1 70  ? 3.73958   -30.48274 8.33562   1.000 88.05792  ? 70  THR H O   1 
ATOM   515  C CB  . THR A 1 70  ? 5.97361   -32.73643 9.62003   1.000 86.61179  ? 70  THR H CB  1 
ATOM   516  O OG1 . THR A 1 70  ? 4.65641   -33.25960 9.84871   1.000 84.39365  ? 70  THR H OG1 1 
ATOM   517  C CG2 . THR A 1 70  ? 6.74491   -32.73410 10.93810  1.000 71.18398  ? 70  THR H CG2 1 
ATOM   518  N N   . ARG A 1 71  ? 4.77500   -31.94821 6.98348   1.000 81.27074  ? 71  ARG H N   1 
ATOM   519  C CA  . ARG A 1 71  ? 3.66066   -31.97755 6.04781   1.000 78.89912  ? 71  ARG H CA  1 
ATOM   520  C C   . ARG A 1 71  ? 3.60477   -33.34045 5.38032   1.000 73.35315  ? 71  ARG H C   1 
ATOM   521  O O   . ARG A 1 71  ? 4.46036   -34.19993 5.59654   1.000 74.60764  ? 71  ARG H O   1 
ATOM   522  C CB  . ARG A 1 71  ? 3.76556   -30.86550 5.00255   1.000 84.78302  ? 71  ARG H CB  1 
ATOM   523  C CG  . ARG A 1 71  ? 4.95477   -30.98107 4.08706   1.000 89.40237  ? 71  ARG H CG  1 
ATOM   524  C CD  . ARG A 1 71  ? 4.91399   -29.88388 3.05115   1.000 95.00523  ? 71  ARG H CD  1 
ATOM   525  N NE  . ARG A 1 71  ? 6.12678   -29.83785 2.24838   1.000 99.84226  ? 71  ARG H NE  1 
ATOM   526  C CZ  . ARG A 1 71  ? 6.31591   -28.99557 1.24408   1.000 102.03781 ? 71  ARG H CZ  1 
ATOM   527  N NH1 . ARG A 1 71  ? 5.38357   -28.12674 0.88914   1.000 100.19784 ? 71  ARG H NH1 1 
ATOM   528  N NH2 . ARG A 1 71  ? 7.46794   -29.02544 0.57996   1.000 104.82524 ? 71  ARG H NH2 1 
ATOM   529  N N   . ASN A 1 72  ? 2.57712   -33.52371 4.55764   1.000 88.19038  ? 72  ASN H N   1 
ATOM   530  C CA  . ASN A 1 72  ? 2.32481   -34.80276 3.90445   1.000 88.95115  ? 72  ASN H CA  1 
ATOM   531  C C   . ASN A 1 72  ? 1.64307   -34.51223 2.57719   1.000 99.67787  ? 72  ASN H C   1 
ATOM   532  O O   . ASN A 1 72  ? 0.45400   -34.17918 2.54987   1.000 103.87666 ? 72  ASN H O   1 
ATOM   533  C CB  . ASN A 1 72  ? 1.45949   -35.70388 4.77973   1.000 99.55866  ? 72  ASN H CB  1 
ATOM   534  C CG  . ASN A 1 72  ? 0.88599   -36.87917 4.01350   1.000 108.86338 ? 72  ASN H CG  1 
ATOM   535  O OD1 . ASN A 1 72  ? 1.52870   -37.42010 3.11280   1.000 116.51003 ? 72  ASN H OD1 1 
ATOM   536  N ND2 . ASN A 1 72  ? -0.33385  -37.27458 4.36030   1.000 98.02349  ? 72  ASN H ND2 1 
ATOM   537  N N   . THR A 1 73  ? 2.39046   -34.64198 1.48113   1.000 104.41420 ? 73  THR H N   1 
ATOM   538  C CA  . THR A 1 73  ? 1.82420   -34.35711 0.16978   1.000 103.45700 ? 73  THR H CA  1 
ATOM   539  C C   . THR A 1 73  ? 0.72554   -35.34190 -0.21268  1.000 102.59892 ? 73  THR H C   1 
ATOM   540  O O   . THR A 1 73  ? -0.08399  -35.03579 -1.09520  1.000 100.27285 ? 73  THR H O   1 
ATOM   541  C CB  . THR A 1 73  ? 2.93352   -34.34926 -0.88388  1.000 101.49487 ? 73  THR H CB  1 
ATOM   542  O OG1 . THR A 1 73  ? 3.68710   -35.56422 -0.79689  1.000 111.86952 ? 73  THR H OG1 1 
ATOM   543  C CG2 . THR A 1 73  ? 3.86877   -33.16694 -0.65477  1.000 95.14678  ? 73  THR H CG2 1 
ATOM   544  N N   . ASN A 1 74  ? 0.66019   -36.50114 0.44680   1.000 100.19769 ? 74  ASN H N   1 
ATOM   545  C CA  . ASN A 1 74  ? -0.35237  -37.49110 0.09492   1.000 109.41830 ? 74  ASN H CA  1 
ATOM   546  C C   . ASN A 1 74  ? -1.75045  -37.05556 0.51329   1.000 110.42905 ? 74  ASN H C   1 
ATOM   547  O O   . ASN A 1 74  ? -2.73766  -37.47819 -0.09947  1.000 104.17460 ? 74  ASN H O   1 
ATOM   548  C CB  . ASN A 1 74  ? -0.00602  -38.83809 0.72408   1.000 109.23653 ? 74  ASN H CB  1 
ATOM   549  C CG  . ASN A 1 74  ? 1.25526   -39.43883 0.14142   1.000 109.77320 ? 74  ASN H CG  1 
ATOM   550  O OD1 . ASN A 1 74  ? 1.19945   -40.21748 -0.81212  1.000 103.46410 ? 74  ASN H OD1 1 
ATOM   551  N ND2 . ASN A 1 74  ? 2.40409   -39.06994 0.70213   1.000 105.57484 ? 74  ASN H ND2 1 
ATOM   552  N N   . GLU A 1 75  ? -1.86261  -36.21933 1.54339   1.000 115.31120 ? 75  GLU H N   1 
ATOM   553  C CA  . GLU A 1 75  ? -3.16409  -35.76791 2.01852   1.000 110.07565 ? 75  GLU H CA  1 
ATOM   554  C C   . GLU A 1 75  ? -3.33533  -34.25738 1.92687   1.000 105.07940 ? 75  GLU H C   1 
ATOM   555  O O   . GLU A 1 75  ? -4.36458  -33.73584 2.37487   1.000 99.95384  ? 75  GLU H O   1 
ATOM   556  C CB  . GLU A 1 75  ? -3.39372  -36.24520 3.45338   1.000 107.93856 ? 75  GLU H CB  1 
ATOM   557  C CG  . GLU A 1 75  ? -3.57713  -37.74578 3.55899   1.000 112.09796 ? 75  GLU H CG  1 
ATOM   558  C CD  . GLU A 1 75  ? -3.72092  -38.20437 4.98717   1.000 123.66475 ? 75  GLU H CD  1 
ATOM   559  O OE1 . GLU A 1 75  ? -3.11907  -37.56281 5.87502   1.000 123.18900 ? 75  GLU H OE1 1 
ATOM   560  O OE2 . GLU A 1 75  ? -4.44091  -39.19799 5.22023   1.000 119.32830 ? 75  GLU H OE2 1 
ATOM   561  N N   . ASN A 1 76  ? -2.36242  -33.54524 1.35145   1.000 103.32912 ? 76  ASN H N   1 
ATOM   562  C CA  . ASN A 1 76  ? -2.45606  -32.09871 1.14545   1.000 100.86926 ? 76  ASN H CA  1 
ATOM   563  C C   . ASN A 1 76  ? -2.60272  -31.37096 2.48274   1.000 91.19933  ? 76  ASN H C   1 
ATOM   564  O O   . ASN A 1 76  ? -3.51047  -30.55872 2.68730   1.000 75.38839  ? 76  ASN H O   1 
ATOM   565  C CB  . ASN A 1 76  ? -3.60683  -31.75360 0.19279   1.000 99.82176  ? 76  ASN H CB  1 
ATOM   566  C CG  . ASN A 1 76  ? -3.24100  -30.66816 -0.80603  1.000 100.10095 ? 76  ASN H CG  1 
ATOM   567  O OD1 . ASN A 1 76  ? -2.06470  -30.44785 -1.11048  1.000 92.49102  ? 76  ASN H OD1 1 
ATOM   568  N ND2 . ASN A 1 76  ? -4.25642  -29.98498 -1.32605  1.000 97.63733  ? 76  ASN H ND2 1 
ATOM   569  N N   . THR A 1 77  ? -1.69064  -31.67721 3.40395   1.000 88.24907  ? 77  THR H N   1 
ATOM   570  C CA  . THR A 1 77  ? -1.74007  -31.14166 4.75433   1.000 84.78265  ? 77  THR H CA  1 
ATOM   571  C C   . THR A 1 77  ? -0.34086  -30.78156 5.22559   1.000 78.43328  ? 77  THR H C   1 
ATOM   572  O O   . THR A 1 77  ? 0.64304   -31.41783 4.84696   1.000 87.52898  ? 77  THR H O   1 
ATOM   573  C CB  . THR A 1 77  ? -2.35166  -32.13988 5.75516   1.000 86.06464  ? 77  THR H CB  1 
ATOM   574  O OG1 . THR A 1 77  ? -1.70446  -33.41289 5.62542   1.000 97.97396  ? 77  THR H OG1 1 
ATOM   575  C CG2 . THR A 1 77  ? -3.85057  -32.29530 5.53627   1.000 73.90328  ? 77  THR H CG2 1 
ATOM   576  N N   . VAL A 1 78  ? -0.26968  -29.75198 6.06144   1.000 75.56068  ? 78  VAL H N   1 
ATOM   577  C CA  . VAL A 1 78  ? 0.90310   -29.44842 6.86985   1.000 72.76677  ? 78  VAL H CA  1 
ATOM   578  C C   . VAL A 1 78  ? 0.44763   -29.44467 8.32616   1.000 71.97902  ? 78  VAL H C   1 
ATOM   579  O O   . VAL A 1 78  ? -0.69414  -29.07435 8.62176   1.000 73.35706  ? 78  VAL H O   1 
ATOM   580  C CB  . VAL A 1 78  ? 1.54378   -28.10484 6.45173   1.000 63.39296  ? 78  VAL H CB  1 
ATOM   581  C CG1 . VAL A 1 78  ? 0.65624   -26.94021 6.80746   1.000 61.99772  ? 78  VAL H CG1 1 
ATOM   582  C CG2 . VAL A 1 78  ? 2.91150   -27.92442 7.07292   1.000 79.55782  ? 78  VAL H CG2 1 
ATOM   583  N N   . THR A 1 79  ? 1.31434   -29.89592 9.23220   1.000 66.43474  ? 79  THR H N   1 
ATOM   584  C CA  . THR A 1 79  ? 0.90598   -30.18478 10.60479  1.000 70.62809  ? 79  THR H CA  1 
ATOM   585  C C   . THR A 1 79  ? 1.86353   -29.55634 11.60577  1.000 56.85940  ? 79  THR H C   1 
ATOM   586  O O   . THR A 1 79  ? 3.07412   -29.77810 11.53310  1.000 73.20965  ? 79  THR H O   1 
ATOM   587  C CB  . THR A 1 79  ? 0.83375   -31.69473 10.85141  1.000 72.07461  ? 79  THR H CB  1 
ATOM   588  O OG1 . THR A 1 79  ? -0.28054  -32.24518 10.14079  1.000 69.51035  ? 79  THR H OG1 1 
ATOM   589  C CG2 . THR A 1 79  ? 0.68800   -31.98767 12.33612  1.000 70.15736  ? 79  THR H CG2 1 
ATOM   590  N N   . LEU A 1 80  ? 1.31893   -28.79162 12.54614  1.000 53.78487  ? 80  LEU H N   1 
ATOM   591  C CA  . LEU A 1 80  ? 2.08652   -28.23710 13.65172  1.000 63.45355  ? 80  LEU H CA  1 
ATOM   592  C C   . LEU A 1 80  ? 1.92909   -29.12500 14.87930  1.000 72.71524  ? 80  LEU H C   1 
ATOM   593  O O   . LEU A 1 80  ? 0.84192   -29.64657 15.14737  1.000 72.45785  ? 80  LEU H O   1 
ATOM   594  C CB  . LEU A 1 80  ? 1.63343   -26.81067 13.97545  1.000 50.71453  ? 80  LEU H CB  1 
ATOM   595  C CG  . LEU A 1 80  ? 2.23096   -26.11887 15.20705  1.000 55.22188  ? 80  LEU H CG  1 
ATOM   596  C CD1 . LEU A 1 80  ? 3.74009   -26.04734 15.12210  1.000 46.15105  ? 80  LEU H CD1 1 
ATOM   597  C CD2 . LEU A 1 80  ? 1.63708   -24.72314 15.41367  1.000 46.45881  ? 80  LEU H CD2 1 
ATOM   598  N N   . LYS A 1 81  ? 3.02468   -29.30302 15.61467  1.000 68.39114  ? 81  LYS H N   1 
ATOM   599  C CA  . LYS A 1 81  ? 3.01846   -30.05204 16.86546  1.000 63.99340  ? 81  LYS H CA  1 
ATOM   600  C C   . LYS A 1 81  ? 3.91173   -29.31967 17.85133  1.000 62.84474  ? 81  LYS H C   1 
ATOM   601  O O   . LYS A 1 81  ? 5.09770   -29.11829 17.57985  1.000 75.92442  ? 81  LYS H O   1 
ATOM   602  C CB  . LYS A 1 81  ? 3.50231   -31.49327 16.66618  1.000 67.49429  ? 81  LYS H CB  1 
ATOM   603  C CG  . LYS A 1 81  ? 2.58209   -32.36672 15.81321  1.000 77.20903  ? 81  LYS H CG  1 
ATOM   604  C CD  . LYS A 1 81  ? 3.14231   -33.78036 15.65126  1.000 76.30318  ? 81  LYS H CD  1 
ATOM   605  C CE  . LYS A 1 81  ? 2.23155   -34.66493 14.80562  1.000 81.91419  ? 81  LYS H CE  1 
ATOM   606  N NZ  . LYS A 1 81  ? 2.80234   -36.02907 14.63842  1.000 75.31106  ? 81  LYS H NZ  1 
ATOM   607  N N   . MET A 1 82  ? 3.34361   -28.89077 18.97057  1.000 56.39654  ? 82  MET H N   1 
ATOM   608  C CA  . MET A 1 82  ? 4.11730   -28.35582 20.08040  1.000 68.54404  ? 82  MET H CA  1 
ATOM   609  C C   . MET A 1 82  ? 4.09054   -29.35691 21.23318  1.000 82.82249  ? 82  MET H C   1 
ATOM   610  O O   . MET A 1 82  ? 3.52180   -30.44849 21.13216  1.000 82.90595  ? 82  MET H O   1 
ATOM   611  C CB  . MET A 1 82  ? 3.59158   -26.98496 20.52977  1.000 57.99120  ? 82  MET H CB  1 
ATOM   612  C CG  . MET A 1 82  ? 3.35279   -25.97721 19.41265  1.000 68.42214  ? 82  MET H CG  1 
ATOM   613  S SD  . MET A 1 82  ? 3.75585   -24.26450 19.84885  1.000 73.96205  ? 82  MET H SD  1 
ATOM   614  C CE  . MET A 1 82  ? 3.39357   -24.23330 21.60290  1.000 60.81758  ? 82  MET H CE  1 
ATOM   615  N N   . ASN A 1 83  A 4.72395   -28.97273 22.33670  1.000 72.85562  ? 82  ASN H N   1 
ATOM   616  C CA  . ASN A 1 83  A 4.78220   -29.79685 23.53557  1.000 61.04653  ? 82  ASN H CA  1 
ATOM   617  C C   . ASN A 1 83  A 5.09746   -28.87464 24.69904  1.000 70.94661  ? 82  ASN H C   1 
ATOM   618  O O   . ASN A 1 83  A 5.45250   -27.70641 24.50535  1.000 62.04628  ? 82  ASN H O   1 
ATOM   619  C CB  . ASN A 1 83  A 5.82740   -30.91364 23.41083  1.000 80.69793  ? 82  ASN H CB  1 
ATOM   620  C CG  . ASN A 1 83  A 7.21908   -30.38898 23.03290  1.000 80.92177  ? 82  ASN H CG  1 
ATOM   621  O OD1 . ASN A 1 83  A 7.66442   -29.33904 23.51086  1.000 73.98569  ? 82  ASN H OD1 1 
ATOM   622  N ND2 . ASN A 1 83  A 7.90357   -31.12149 22.16045  1.000 78.16842  ? 82  ASN H ND2 1 
ATOM   623  N N   . SER A 1 84  B 4.97486   -29.41451 25.91351  1.000 65.15496  ? 82  SER H N   1 
ATOM   624  C CA  . SER A 1 84  B 5.26963   -28.64096 27.11575  1.000 65.43404  ? 82  SER H CA  1 
ATOM   625  C C   . SER A 1 84  B 4.33072   -27.44033 27.21329  1.000 65.00028  ? 82  SER H C   1 
ATOM   626  O O   . SER A 1 84  B 4.74514   -26.31995 27.53378  1.000 52.15135  ? 82  SER H O   1 
ATOM   627  C CB  . SER A 1 84  B 6.74607   -28.21714 27.13808  1.000 63.11370  ? 82  SER H CB  1 
ATOM   628  O OG  . SER A 1 84  B 6.96285   -27.04507 27.89793  1.000 63.34980  ? 82  SER H OG  1 
ATOM   629  N N   . LEU A 1 85  C 3.05022   -27.68573 26.92218  1.000 67.15539  ? 82  LEU H N   1 
ATOM   630  C CA  . LEU A 1 85  C 2.07277   -26.61268 26.83766  1.000 60.50731  ? 82  LEU H CA  1 
ATOM   631  C C   . LEU A 1 85  C 1.86681   -25.96191 28.20233  1.000 60.75792  ? 82  LEU H C   1 
ATOM   632  O O   . LEU A 1 85  C 2.15541   -26.54014 29.25163  1.000 55.07732  ? 82  LEU H O   1 
ATOM   633  C CB  . LEU A 1 85  C 0.75264   -27.14123 26.28057  1.000 63.81717  ? 82  LEU H CB  1 
ATOM   634  C CG  . LEU A 1 85  C 0.82975   -27.60097 24.82236  1.000 56.48116  ? 82  LEU H CG  1 
ATOM   635  C CD1 . LEU A 1 85  C -0.50213  -28.13127 24.32271  1.000 65.03446  ? 82  LEU H CD1 1 
ATOM   636  C CD2 . LEU A 1 85  C 1.32316   -26.48639 23.93163  1.000 53.87327  ? 82  LEU H CD2 1 
ATOM   637  N N   . ARG A 1 86  ? 1.37698   -24.72713 28.17259  1.000 65.08950  ? 83  ARG H N   1 
ATOM   638  C CA  . ARG A 1 86  ? 1.19867   -23.93766 29.37967  1.000 55.74961  ? 83  ARG H CA  1 
ATOM   639  C C   . ARG A 1 86  ? 0.11313   -22.89693 29.12783  1.000 67.54413  ? 83  ARG H C   1 
ATOM   640  O O   . ARG A 1 86  ? -0.47617  -22.83147 28.04430  1.000 64.20019  ? 83  ARG H O   1 
ATOM   641  C CB  . ARG A 1 86  ? 2.51811   -23.28715 29.80619  1.000 56.17764  ? 83  ARG H CB  1 
ATOM   642  C CG  . ARG A 1 86  ? 2.99297   -22.15947 28.89789  1.000 78.45913  ? 83  ARG H CG  1 
ATOM   643  C CD  . ARG A 1 86  ? 4.47093   -21.86170 29.11617  1.000 91.26107  ? 83  ARG H CD  1 
ATOM   644  N NE  . ARG A 1 86  ? 4.77032   -21.56214 30.51225  1.000 112.56010 ? 83  ARG H NE  1 
ATOM   645  C CZ  . ARG A 1 86  ? 5.99341   -21.40430 31.00336  1.000 128.42505 ? 83  ARG H CZ  1 
ATOM   646  N NH1 . ARG A 1 86  ? 7.06706   -21.52181 30.23747  1.000 133.05241 ? 83  ARG H NH1 1 
ATOM   647  N NH2 . ARG A 1 86  ? 6.14345   -21.12362 32.29639  1.000 114.81679 ? 83  ARG H NH2 1 
ATOM   648  N N   . ALA A 1 87  ? -0.14022  -22.07168 30.14808  1.000 72.56757  ? 84  ALA H N   1 
ATOM   649  C CA  . ALA A 1 87  ? -1.21312  -21.08271 30.07175  1.000 75.39528  ? 84  ALA H CA  1 
ATOM   650  C C   . ALA A 1 87  ? -1.04233  -20.15618 28.87344  1.000 67.88274  ? 84  ALA H C   1 
ATOM   651  O O   . ALA A 1 87  ? -2.00767  -19.87574 28.15227  1.000 70.09853  ? 84  ALA H O   1 
ATOM   652  C CB  . ALA A 1 87  ? -1.26744  -20.27348 31.36825  1.000 62.62275  ? 84  ALA H CB  1 
ATOM   653  N N   . GLU A 1 88  ? 0.18003   -19.67827 28.63747  1.000 70.99108  ? 85  GLU H N   1 
ATOM   654  C CA  . GLU A 1 88  ? 0.40967   -18.72057 27.56296  1.000 69.49520  ? 85  GLU H CA  1 
ATOM   655  C C   . GLU A 1 88  ? 0.30051   -19.34786 26.18299  1.000 62.23078  ? 85  GLU H C   1 
ATOM   656  O O   . GLU A 1 88  ? 0.25113   -18.60821 25.19777  1.000 58.19050  ? 85  GLU H O   1 
ATOM   657  C CB  . GLU A 1 88  ? 1.77874   -18.05368 27.71327  1.000 72.71812  ? 85  GLU H CB  1 
ATOM   658  C CG  . GLU A 1 88  ? 1.94710   -17.29632 29.01693  1.000 79.03945  ? 85  GLU H CG  1 
ATOM   659  C CD  . GLU A 1 88  ? 2.18477   -18.22378 30.19631  1.000 95.90020  ? 85  GLU H CD  1 
ATOM   660  O OE1 . GLU A 1 88  ? 3.10814   -19.06396 30.10213  1.000 95.96299  ? 85  GLU H OE1 1 
ATOM   661  O OE2 . GLU A 1 88  ? 1.43499   -18.13204 31.19768  1.000 86.46600  ? 85  GLU H OE2 1 
ATOM   662  N N   . ASP A 1 89  ? 0.26084   -20.67688 26.08635  1.000 48.23697  ? 86  ASP H N   1 
ATOM   663  C CA  . ASP A 1 89  ? 0.05495   -21.32579 24.80347  1.000 44.44937  ? 86  ASP H CA  1 
ATOM   664  C C   . ASP A 1 89  ? -1.40562  -21.37095 24.38159  1.000 64.24250  ? 86  ASP H C   1 
ATOM   665  O O   . ASP A 1 89  ? -1.69025  -21.72265 23.23049  1.000 55.32688  ? 86  ASP H O   1 
ATOM   666  C CB  . ASP A 1 89  ? 0.60408   -22.74364 24.83186  1.000 55.42786  ? 86  ASP H CB  1 
ATOM   667  C CG  . ASP A 1 89  ? 2.09748   -22.77389 24.90061  1.000 67.61136  ? 86  ASP H CG  1 
ATOM   668  O OD1 . ASP A 1 89  ? 2.70842   -21.68647 25.01066  1.000 70.86655  ? 86  ASP H OD1 1 
ATOM   669  O OD2 . ASP A 1 89  ? 2.66024   -23.88452 24.84546  1.000 69.64972  ? 86  ASP H OD2 1 
ATOM   670  N N   . THR A 1 90  ? -2.33634  -21.05068 25.27152  1.000 55.12223  ? 87  THR H N   1 
ATOM   671  C CA  . THR A 1 90  ? -3.72803  -20.95520 24.86049  1.000 56.80423  ? 87  THR H CA  1 
ATOM   672  C C   . THR A 1 90  ? -3.87559  -19.79342 23.88652  1.000 44.58996  ? 87  THR H C   1 
ATOM   673  O O   . THR A 1 90  ? -3.58524  -18.64126 24.22719  1.000 42.57693  ? 87  THR H O   1 
ATOM   674  C CB  . THR A 1 90  ? -4.64599  -20.77707 26.07053  1.000 63.77488  ? 87  THR H CB  1 
ATOM   675  O OG1 . THR A 1 90  ? -4.57017  -21.93764 26.91185  1.000 55.07205  ? 87  THR H OG1 1 
ATOM   676  C CG2 . THR A 1 90  ? -6.08016  -20.59655 25.62108  1.000 36.23234  ? 87  THR H CG2 1 
ATOM   677  N N   . ALA A 1 91  ? -4.30484  -20.10239 22.66991  1.000 45.74355  ? 88  ALA H N   1 
ATOM   678  C CA  . ALA A 1 91  ? -4.41468  -19.10184 21.62208  1.000 45.17088  ? 88  ALA H CA  1 
ATOM   679  C C   . ALA A 1 91  ? -5.24036  -19.68817 20.49360  1.000 40.95752  ? 88  ALA H C   1 
ATOM   680  O O   . ALA A 1 91  ? -5.59879  -20.86984 20.50273  1.000 41.17359  ? 88  ALA H O   1 
ATOM   681  C CB  . ALA A 1 91  ? -3.04066  -18.66844 21.10537  1.000 54.07560  ? 88  ALA H CB  1 
ATOM   682  N N   . VAL A 1 92  ? -5.54069  -18.83964 19.52277  1.000 39.83477  ? 89  VAL H N   1 
ATOM   683  C CA  . VAL A 1 92  ? -6.07095  -19.28858 18.24436  1.000 42.81497  ? 89  VAL H CA  1 
ATOM   684  C C   . VAL A 1 92  ? -4.89654  -19.50332 17.30455  1.000 40.90696  ? 89  VAL H C   1 
ATOM   685  O O   . VAL A 1 92  ? -4.01234  -18.64781 17.19204  1.000 36.44885  ? 89  VAL H O   1 
ATOM   686  C CB  . VAL A 1 92  ? -7.07033  -18.27460 17.66626  1.000 46.82878  ? 89  VAL H CB  1 
ATOM   687  C CG1 . VAL A 1 92  ? -7.45769  -18.66747 16.24692  1.000 41.96762  ? 89  VAL H CG1 1 
ATOM   688  C CG2 . VAL A 1 92  ? -8.31077  -18.19840 18.55362  1.000 34.38993  ? 89  VAL H CG2 1 
ATOM   689  N N   . TYR A 1 93  ? -4.87933  -20.65034 16.64496  1.000 39.11225  ? 90  TYR H N   1 
ATOM   690  C CA  . TYR A 1 93  ? -3.75189  -21.08073 15.83937  1.000 49.24779  ? 90  TYR H CA  1 
ATOM   691  C C   . TYR A 1 93  ? -4.16537  -21.10050 14.37348  1.000 54.65967  ? 90  TYR H C   1 
ATOM   692  O O   . TYR A 1 93  ? -5.10505  -21.81103 13.99778  1.000 50.06785  ? 90  TYR H O   1 
ATOM   693  C CB  . TYR A 1 93  ? -3.26076  -22.44851 16.31347  1.000 49.52631  ? 90  TYR H CB  1 
ATOM   694  C CG  . TYR A 1 93  ? -2.44168  -22.37918 17.59021  1.000 51.43416  ? 90  TYR H CG  1 
ATOM   695  C CD1 . TYR A 1 93  ? -3.05210  -22.35989 18.84521  1.000 49.80916  ? 90  TYR H CD1 1 
ATOM   696  C CD2 . TYR A 1 93  ? -1.05445  -22.31080 17.53972  1.000 52.75168  ? 90  TYR H CD2 1 
ATOM   697  C CE1 . TYR A 1 93  ? -2.29057  -22.27937 20.01190  1.000 50.21216  ? 90  TYR H CE1 1 
ATOM   698  C CE2 . TYR A 1 93  ? -0.29122  -22.23011 18.69375  1.000 46.98067  ? 90  TYR H CE2 1 
ATOM   699  C CZ  . TYR A 1 93  ? -0.90566  -22.21840 19.92302  1.000 58.42222  ? 90  TYR H CZ  1 
ATOM   700  O OH  . TYR A 1 93  ? -0.11860  -22.13422 21.05460  1.000 62.22012  ? 90  TYR H OH  1 
ATOM   701  N N   . TYR A 1 94  ? -3.47518  -20.30232 13.55830  1.000 53.21581  ? 91  TYR H N   1 
ATOM   702  C CA  . TYR A 1 94  ? -3.71994  -20.20768 12.12686  1.000 46.82774  ? 91  TYR H CA  1 
ATOM   703  C C   . TYR A 1 94  ? -2.53599  -20.77078 11.35458  1.000 51.22093  ? 91  TYR H C   1 
ATOM   704  O O   . TYR A 1 94  ? -1.37976  -20.57571 11.73716  1.000 49.81249  ? 91  TYR H O   1 
ATOM   705  C CB  . TYR A 1 94  ? -3.91443  -18.75661 11.66123  1.000 45.84017  ? 91  TYR H CB  1 
ATOM   706  C CG  . TYR A 1 94  ? -4.96123  -17.91772 12.36106  1.000 45.81607  ? 91  TYR H CG  1 
ATOM   707  C CD1 . TYR A 1 94  ? -6.27676  -17.89150 11.91892  1.000 48.95102  ? 91  TYR H CD1 1 
ATOM   708  C CD2 . TYR A 1 94  ? -4.61763  -17.10137 13.42946  1.000 45.24642  ? 91  TYR H CD2 1 
ATOM   709  C CE1 . TYR A 1 94  ? -7.22978  -17.10187 12.54990  1.000 45.75898  ? 91  TYR H CE1 1 
ATOM   710  C CE2 . TYR A 1 94  ? -5.55845  -16.31168 14.05968  1.000 47.39986  ? 91  TYR H CE2 1 
ATOM   711  C CZ  . TYR A 1 94  ? -6.86099  -16.31339 13.61784  1.000 44.79910  ? 91  TYR H CZ  1 
ATOM   712  O OH  . TYR A 1 94  ? -7.78268  -15.51927 14.26115  1.000 54.36192  ? 91  TYR H OH  1 
ATOM   713  N N   . CYS A 1 95  ? -2.83122  -21.44628 10.25085  1.000 49.62344  ? 92  CYS H N   1 
ATOM   714  C CA  . CYS A 1 95  ? -1.86153  -21.67973 9.19311   1.000 50.16097  ? 92  CYS H CA  1 
ATOM   715  C C   . CYS A 1 95  ? -2.15880  -20.71574 8.05621   1.000 55.83096  ? 92  CYS H C   1 
ATOM   716  O O   . CYS A 1 95  ? -3.32126  -20.39341 7.79642   1.000 56.09072  ? 92  CYS H O   1 
ATOM   717  C CB  . CYS A 1 95  ? -1.91365  -23.10986 8.67386   1.000 57.55306  ? 92  CYS H CB  1 
ATOM   718  S SG  . CYS A 1 95  ? -3.54276  -23.58077 8.11148   0.661 57.33729  ? 92  CYS H SG  1 
ATOM   719  N N   . ALA A 1 96  ? -1.11203  -20.25826 7.37664   1.000 58.91349  ? 93  ALA H N   1 
ATOM   720  C CA  . ALA A 1 96  ? -1.30322  -19.21851 6.37787   1.000 59.62188  ? 93  ALA H CA  1 
ATOM   721  C C   . ALA A 1 96  ? -0.03387  -19.04222 5.56243   1.000 62.59982  ? 93  ALA H C   1 
ATOM   722  O O   . ALA A 1 96  ? 1.06982   -19.03773 6.11660   1.000 54.52246  ? 93  ALA H O   1 
ATOM   723  C CB  . ALA A 1 96  ? -1.67944  -17.88639 7.03608   1.000 53.30947  ? 93  ALA H CB  1 
ATOM   724  N N   . LYS A 1 97  ? -0.19855  -18.89364 4.24931   1.000 61.56095  ? 94  LYS H N   1 
ATOM   725  C CA  . LYS A 1 97  ? 0.88399   -18.39735 3.40722   1.000 61.41371  ? 94  LYS H CA  1 
ATOM   726  C C   . LYS A 1 97  ? 0.89900   -16.88821 3.57796   1.000 61.46810  ? 94  LYS H C   1 
ATOM   727  O O   . LYS A 1 97  ? 0.05947   -16.18252 3.01689   1.000 66.02634  ? 94  LYS H O   1 
ATOM   728  C CB  . LYS A 1 97  ? 0.68830   -18.79054 1.94960   1.000 55.57026  ? 94  LYS H CB  1 
ATOM   729  C CG  . LYS A 1 97  ? 1.84626   -18.32741 1.07941   1.000 73.46658  ? 94  LYS H CG  1 
ATOM   730  C CD  . LYS A 1 97  ? 1.65796   -18.65350 -0.38968  1.000 69.68454  ? 94  LYS H CD  1 
ATOM   731  C CE  . LYS A 1 97  ? 2.85759   -18.18458 -1.19616  1.000 55.09166  ? 94  LYS H CE  1 
ATOM   732  N NZ  . LYS A 1 97  ? 3.04641   -16.71718 -1.09862  1.000 48.05405  ? 94  LYS H NZ  1 
ATOM   733  N N   . LEU A 1 98  ? 1.84661   -16.39292 4.37677   1.000 57.18397  ? 95  LEU H N   1 
ATOM   734  C CA  . LEU A 1 98  ? 1.81757   -14.99231 4.78508   1.000 56.88172  ? 95  LEU H CA  1 
ATOM   735  C C   . LEU A 1 98  ? 1.92814   -14.05856 3.59069   1.000 60.92357  ? 95  LEU H C   1 
ATOM   736  O O   . LEU A 1 98  ? 1.33750   -12.96975 3.59172   1.000 48.25440  ? 95  LEU H O   1 
ATOM   737  C CB  . LEU A 1 98  ? 2.93158   -14.71995 5.79069   1.000 53.30921  ? 95  LEU H CB  1 
ATOM   738  C CG  . LEU A 1 98  ? 2.65258   -15.38117 7.13611   1.000 56.09010  ? 95  LEU H CG  1 
ATOM   739  C CD1 . LEU A 1 98  ? 3.62011   -14.91054 8.20095   1.000 52.16316  ? 95  LEU H CD1 1 
ATOM   740  C CD2 . LEU A 1 98  ? 1.21163   -15.09981 7.55196   1.000 56.51222  ? 95  LEU H CD2 1 
ATOM   741  N N   . GLY A 1 99  ? 2.66572   -14.47709 2.55834   1.000 70.65050  ? 96  GLY H N   1 
ATOM   742  C CA  . GLY A 1 99  ? 2.87292   -13.68360 1.36256   1.000 65.42681  ? 96  GLY H CA  1 
ATOM   743  C C   . GLY A 1 99  ? 3.24153   -12.24203 1.64402   1.000 62.47586  ? 96  GLY H C   1 
ATOM   744  O O   . GLY A 1 99  ? 2.50642   -11.32247 1.26827   1.000 64.29929  ? 96  GLY H O   1 
ATOM   745  N N   . THR A 1 100 ? 4.36173   -12.02187 2.32277   1.000 58.65522  ? 97  THR H N   1 
ATOM   746  C CA  . THR A 1 100 ? 4.77554   -10.64863 2.55072   1.000 62.86167  ? 97  THR H CA  1 
ATOM   747  C C   . THR A 1 100 ? 5.48273   -10.04506 1.34329   1.000 70.13855  ? 97  THR H C   1 
ATOM   748  O O   . THR A 1 100 ? 5.60231   -8.81632  1.26586   1.000 69.34767  ? 97  THR H O   1 
ATOM   749  C CB  . THR A 1 100 ? 5.66684   -10.56569 3.79244   1.000 60.69447  ? 97  THR H CB  1 
ATOM   750  O OG1 . THR A 1 100 ? 6.82265   -11.39202 3.62171   1.000 53.12890  ? 97  THR H OG1 1 
ATOM   751  C CG2 . THR A 1 100 ? 4.89341   -11.02891 5.02000   1.000 65.94192  ? 97  THR H CG2 1 
ATOM   752  N N   . GLY A 1 101 ? 5.92701   -10.86745 0.39482   1.000 60.70618  ? 98  GLY H N   1 
ATOM   753  C CA  . GLY A 1 101 ? 6.59748   -10.35331 -0.77858  1.000 63.26435  ? 98  GLY H CA  1 
ATOM   754  C C   . GLY A 1 101 ? 6.17633   -11.01799 -2.06934  1.000 53.85978  ? 98  GLY H C   1 
ATOM   755  O O   . GLY A 1 101 ? 6.81832   -10.80912 -3.09756  1.000 75.37458  ? 98  GLY H O   1 
ATOM   756  N N   . SER A 1 102 ? 5.11655   -11.82322 -2.03781  1.000 57.53618  ? 99  SER H N   1 
ATOM   757  C CA  . SER A 1 102 ? 4.57093   -12.45490 -3.23167  1.000 58.70821  ? 99  SER H CA  1 
ATOM   758  C C   . SER A 1 102 ? 3.07040   -12.19476 -3.28615  1.000 72.05328  ? 99  SER H C   1 
ATOM   759  O O   . SER A 1 102 ? 2.45940   -11.76560 -2.30375  1.000 65.01268  ? 99  SER H O   1 
ATOM   760  C CB  . SER A 1 102 ? 4.86824   -13.96741 -3.26965  1.000 54.43048  ? 99  SER H CB  1 
ATOM   761  O OG  . SER A 1 102 ? 4.49260   -14.60230 -2.06126  1.000 66.40334  ? 99  SER H OG  1 
ATOM   762  N N   . ARG A 1 103 ? 2.48121   -12.44156 -4.45989  1.000 68.84970  ? 100 ARG H N   1 
ATOM   763  C CA  . ARG A 1 103 ? 1.07821   -12.09483 -4.66482  1.000 66.64067  ? 100 ARG H CA  1 
ATOM   764  C C   . ARG A 1 103 ? 0.15288   -13.01554 -3.88295  1.000 67.36675  ? 100 ARG H C   1 
ATOM   765  O O   . ARG A 1 103 ? -0.83574  -12.55733 -3.29850  1.000 75.50533  ? 100 ARG H O   1 
ATOM   766  C CB  . ARG A 1 103 ? 0.72596   -12.14276 -6.15244  1.000 75.50669  ? 100 ARG H CB  1 
ATOM   767  C CG  . ARG A 1 103 ? 1.33534   -11.03328 -6.99269  1.000 81.27328  ? 100 ARG H CG  1 
ATOM   768  C CD  . ARG A 1 103 ? 0.54576   -10.82355 -8.28149  1.000 97.35561  ? 100 ARG H CD  1 
ATOM   769  N NE  . ARG A 1 103 ? -0.78554  -10.27745 -8.03269  1.000 99.99825  ? 100 ARG H NE  1 
ATOM   770  C CZ  . ARG A 1 103 ? -1.71456  -10.11049 -8.96541  1.000 104.97658 ? 100 ARG H CZ  1 
ATOM   771  N NH1 . ARG A 1 103 ? -1.49893  -10.45994 -10.22529 1.000 94.60246  ? 100 ARG H NH1 1 
ATOM   772  N NH2 . ARG A 1 103 ? -2.88914  -9.58048  -8.62543  1.000 93.28888  ? 100 ARG H NH2 1 
ATOM   773  N N   . PHE A 1 104 A 0.44174   -14.31361 -3.87234  1.000 65.77793  ? 100 PHE H N   1 
ATOM   774  C CA  . PHE A 1 104 A -0.44940  -15.28343 -3.24694  1.000 65.30769  ? 100 PHE H CA  1 
ATOM   775  C C   . PHE A 1 104 A -0.26558  -15.25708 -1.73342  1.000 66.90681  ? 100 PHE H C   1 
ATOM   776  O O   . PHE A 1 104 A 0.83769   -15.49615 -1.22615  1.000 63.06484  ? 100 PHE H O   1 
ATOM   777  C CB  . PHE A 1 104 A -0.19107  -16.68234 -3.80467  1.000 66.58311  ? 100 PHE H CB  1 
ATOM   778  C CG  . PHE A 1 104 A -1.18796  -17.71828 -3.35106  1.000 77.34148  ? 100 PHE H CG  1 
ATOM   779  C CD1 . PHE A 1 104 A -2.51239  -17.37705 -3.10598  1.000 77.33213  ? 100 PHE H CD1 1 
ATOM   780  C CD2 . PHE A 1 104 A -0.79313  -19.03611 -3.16244  1.000 80.34264  ? 100 PHE H CD2 1 
ATOM   781  C CE1 . PHE A 1 104 A -3.42631  -18.33492 -2.68857  1.000 76.43744  ? 100 PHE H CE1 1 
ATOM   782  C CE2 . PHE A 1 104 A -1.69779  -19.99836 -2.74658  1.000 81.04091  ? 100 PHE H CE2 1 
ATOM   783  C CZ  . PHE A 1 104 A -3.01726  -19.64827 -2.50822  1.000 84.17885  ? 100 PHE H CZ  1 
ATOM   784  N N   . ALA A 1 105 ? -1.34552  -14.94020 -1.02249  1.000 69.08857  ? 101 ALA H N   1 
ATOM   785  C CA  . ALA A 1 105 ? -1.41940  -15.06102 0.42556   1.000 62.46525  ? 101 ALA H CA  1 
ATOM   786  C C   . ALA A 1 105 ? -2.78128  -15.63600 0.76227   1.000 64.14211  ? 101 ALA H C   1 
ATOM   787  O O   . ALA A 1 105 ? -3.79780  -15.16245 0.24607   1.000 60.08008  ? 101 ALA H O   1 
ATOM   788  C CB  . ALA A 1 105 ? -1.22089  -13.71444 1.12792   1.000 49.63839  ? 101 ALA H CB  1 
ATOM   789  N N   . ILE A 1 106 ? -2.79926  -16.65885 1.61061   1.000 69.25450  ? 102 ILE H N   1 
ATOM   790  C CA  . ILE A 1 106 ? -4.03355  -17.33925 1.97886   1.000 62.01376  ? 102 ILE H CA  1 
ATOM   791  C C   . ILE A 1 106 ? -3.96178  -17.69289 3.45809   1.000 74.22030  ? 102 ILE H C   1 
ATOM   792  O O   . ILE A 1 106 ? -2.94418  -18.20930 3.93109   1.000 73.90966  ? 102 ILE H O   1 
ATOM   793  C CB  . ILE A 1 106 ? -4.26634  -18.59049 1.10930   1.000 60.66076  ? 102 ILE H CB  1 
ATOM   794  C CG1 . ILE A 1 106 ? -5.55482  -19.30619 1.50868   1.000 65.42000  ? 102 ILE H CG1 1 
ATOM   795  C CG2 . ILE A 1 106 ? -3.07267  -19.53411 1.17730   1.000 70.18700  ? 102 ILE H CG2 1 
ATOM   796  C CD1 . ILE A 1 106 ? -5.81820  -20.55280 0.68424   1.000 71.97615  ? 102 ILE H CD1 1 
ATOM   797  N N   . TRP A 1 107 ? -5.02856  -17.38880 4.19237   1.000 70.70854  ? 103 TRP H N   1 
ATOM   798  C CA  . TRP A 1 107 ? -5.10972  -17.65865 5.61781   1.000 61.60588  ? 103 TRP H CA  1 
ATOM   799  C C   . TRP A 1 107 ? -6.15152  -18.72349 5.90679   1.000 67.13565  ? 103 TRP H C   1 
ATOM   800  O O   . TRP A 1 107 ? -7.04910  -18.98527 5.10285   1.000 75.14337  ? 103 TRP H O   1 
ATOM   801  C CB  . TRP A 1 107 ? -5.45999  -16.40056 6.40748   1.000 52.92872  ? 103 TRP H CB  1 
ATOM   802  C CG  . TRP A 1 107 ? -4.26479  -15.62022 6.74105   1.000 63.24927  ? 103 TRP H CG  1 
ATOM   803  C CD1 . TRP A 1 107 ? -3.39717  -15.04670 5.86394   1.000 64.65057  ? 103 TRP H CD1 1 
ATOM   804  C CD2 . TRP A 1 107 ? -3.76861  -15.33008 8.05011   1.000 57.95223  ? 103 TRP H CD2 1 
ATOM   805  N NE1 . TRP A 1 107 ? -2.39188  -14.40605 6.54413   1.000 66.92476  ? 103 TRP H NE1 1 
ATOM   806  C CE2 . TRP A 1 107 ? -2.59757  -14.56557 7.89009   1.000 56.90312  ? 103 TRP H CE2 1 
ATOM   807  C CE3 . TRP A 1 107 ? -4.20001  -15.64072 9.34039   1.000 50.53478  ? 103 TRP H CE3 1 
ATOM   808  C CZ2 . TRP A 1 107 ? -1.85784  -14.10298 8.97102   1.000 51.43890  ? 103 TRP H CZ2 1 
ATOM   809  C CZ3 . TRP A 1 107 ? -3.45971  -15.18554 10.40925  1.000 46.14023  ? 103 TRP H CZ3 1 
ATOM   810  C CH2 . TRP A 1 107 ? -2.30567  -14.42075 10.22091  1.000 46.13552  ? 103 TRP H CH2 1 
ATOM   811  N N   . GLY A 1 108 ? -6.02005  -19.33134 7.07643   1.000 64.70384  ? 104 GLY H N   1 
ATOM   812  C CA  . GLY A 1 108 ? -7.04751  -20.21684 7.57037   1.000 60.44927  ? 104 GLY H CA  1 
ATOM   813  C C   . GLY A 1 108 ? -8.03368  -19.48130 8.44626   1.000 56.09776  ? 104 GLY H C   1 
ATOM   814  O O   . GLY A 1 108 ? -7.84283  -18.31810 8.79961   1.000 60.09714  ? 104 GLY H O   1 
ATOM   815  N N   . GLN A 1 109 ? -9.11248  -20.17913 8.79095   1.000 60.49884  ? 105 GLN H N   1 
ATOM   816  C CA  . GLN A 1 109 ? -10.07628 -19.62201 9.72832   1.000 69.24435  ? 105 GLN H CA  1 
ATOM   817  C C   . GLN A 1 109 ? -9.58965  -19.70599 11.16829  1.000 66.74466  ? 105 GLN H C   1 
ATOM   818  O O   . GLN A 1 109 ? -10.12263 -19.00047 12.03127  1.000 68.81709  ? 105 GLN H O   1 
ATOM   819  C CB  . GLN A 1 109 ? -11.42737 -20.33070 9.58157   1.000 84.73319  ? 105 GLN H CB  1 
ATOM   820  C CG  . GLN A 1 109 ? -11.52222 -21.68066 10.28322  1.000 94.41105  ? 105 GLN H CG  1 
ATOM   821  C CD  . GLN A 1 109 ? -10.67218 -22.76792 9.63104   1.000 97.97032  ? 105 GLN H CD  1 
ATOM   822  O OE1 . GLN A 1 109 ? -10.42123 -22.74131 8.42102   1.000 90.78658  ? 105 GLN H OE1 1 
ATOM   823  N NE2 . GLN A 1 109 ? -10.22421 -23.73283 10.43813  1.000 89.47478  ? 105 GLN H NE2 1 
ATOM   824  N N   . GLY A 1 110 ? -8.58598  -20.53428 11.43924  1.000 64.28318  ? 106 GLY H N   1 
ATOM   825  C CA  . GLY A 1 110 ? -8.03438  -20.67196 12.76916  1.000 64.38154  ? 106 GLY H CA  1 
ATOM   826  C C   . GLY A 1 110 ? -8.69530  -21.78402 13.56503  1.000 64.62453  ? 106 GLY H C   1 
ATOM   827  O O   . GLY A 1 110 ? -9.75383  -22.30282 13.21449  1.000 64.69367  ? 106 GLY H O   1 
ATOM   828  N N   . THR A 1 111 ? -8.03457  -22.16119 14.65708  1.000 60.34207  ? 107 THR H N   1 
ATOM   829  C CA  . THR A 1 111 ? -8.58557  -23.14089 15.58073  1.000 54.75626  ? 107 THR H CA  1 
ATOM   830  C C   . THR A 1 111 ? -8.07231  -22.83680 16.98036  1.000 49.88516  ? 107 THR H C   1 
ATOM   831  O O   . THR A 1 111 ? -6.97143  -22.30895 17.15745  1.000 43.66557  ? 107 THR H O   1 
ATOM   832  C CB  . THR A 1 111 ? -8.23740  -24.57653 15.18298  1.000 51.60762  ? 107 THR H CB  1 
ATOM   833  O OG1 . THR A 1 111 ? -9.09636  -25.47882 15.88791  1.000 53.72826  ? 107 THR H OG1 1 
ATOM   834  C CG2 . THR A 1 111 ? -6.79189  -24.88910 15.53278  1.000 61.55077  ? 107 THR H CG2 1 
ATOM   835  N N   . LEU A 1 112 ? -8.89527  -23.14374 17.97352  1.000 57.72112  ? 108 LEU H N   1 
ATOM   836  C CA  . LEU A 1 112 ? -8.60631  -22.77966 19.35176  1.000 54.87530  ? 108 LEU H CA  1 
ATOM   837  C C   . LEU A 1 112 ? -7.94250  -23.94292 20.06879  1.000 45.48106  ? 108 LEU H C   1 
ATOM   838  O O   . LEU A 1 112 ? -8.47727  -25.05785 20.08659  1.000 45.11258  ? 108 LEU H O   1 
ATOM   839  C CB  . LEU A 1 112 ? -9.87724  -22.37172 20.09590  1.000 37.32662  ? 108 LEU H CB  1 
ATOM   840  C CG  . LEU A 1 112 ? -9.64058  -22.07897 21.58290  1.000 48.47217  ? 108 LEU H CG  1 
ATOM   841  C CD1 . LEU A 1 112 ? -8.71792  -20.87846 21.76896  1.000 43.39327  ? 108 LEU H CD1 1 
ATOM   842  C CD2 . LEU A 1 112 ? -10.94992 -21.86588 22.31084  1.000 38.52746  ? 108 LEU H CD2 1 
ATOM   843  N N   . VAL A 1 113 ? -6.77842  -23.67603 20.64955  1.000 50.19375  ? 109 VAL H N   1 
ATOM   844  C CA  . VAL A 1 113 ? -6.11189  -24.58901 21.56951  1.000 47.64301  ? 109 VAL H CA  1 
ATOM   845  C C   . VAL A 1 113 ? -6.24654  -24.00124 22.96211  1.000 36.92669  ? 109 VAL H C   1 
ATOM   846  O O   . VAL A 1 113 ? -5.78585  -22.88025 23.21491  1.000 45.63905  ? 109 VAL H O   1 
ATOM   847  C CB  . VAL A 1 113 ? -4.63607  -24.78764 21.20667  1.000 46.45364  ? 109 VAL H CB  1 
ATOM   848  C CG1 . VAL A 1 113 ? -3.95832  -25.61204 22.27671  1.000 47.71625  ? 109 VAL H CG1 1 
ATOM   849  C CG2 . VAL A 1 113 ? -4.51526  -25.44360 19.84637  1.000 46.33855  ? 109 VAL H CG2 1 
ATOM   850  N N   . THR A 1 114 ? -6.88748  -24.73927 23.86132  1.000 40.61167  ? 110 THR H N   1 
ATOM   851  C CA  . THR A 1 114 ? -7.08966  -24.28034 25.23005  1.000 43.31281  ? 110 THR H CA  1 
ATOM   852  C C   . THR A 1 114 ? -6.27864  -25.16059 26.17071  1.000 44.78138  ? 110 THR H C   1 
ATOM   853  O O   . THR A 1 114 ? -6.41055  -26.39015 26.15023  1.000 42.64674  ? 110 THR H O   1 
ATOM   854  C CB  . THR A 1 114 ? -8.56977  -24.29421 25.60940  1.000 42.65608  ? 110 THR H CB  1 
ATOM   855  O OG1 . THR A 1 114 ? -9.33111  -23.68691 24.55692  1.000 43.12900  ? 110 THR H OG1 1 
ATOM   856  C CG2 . THR A 1 114 ? -8.78391  -23.50901 26.89840  1.000 39.12609  ? 110 THR H CG2 1 
ATOM   857  N N   . VAL A 1 115 ? -5.42735  -24.52994 26.97068  1.000 43.57145  ? 111 VAL H N   1 
ATOM   858  C CA  . VAL A 1 115 ? -4.64326  -25.21138 27.99216  1.000 58.36794  ? 111 VAL H CA  1 
ATOM   859  C C   . VAL A 1 115 ? -5.35277  -25.00864 29.32195  1.000 47.94403  ? 111 VAL H C   1 
ATOM   860  O O   . VAL A 1 115 ? -5.59255  -23.86733 29.73667  1.000 50.41202  ? 111 VAL H O   1 
ATOM   861  C CB  . VAL A 1 115 ? -3.19957  -24.68184 28.03509  1.000 66.24075  ? 111 VAL H CB  1 
ATOM   862  C CG1 . VAL A 1 115 ? -2.46975  -25.18183 29.27768  1.000 45.22061  ? 111 VAL H CG1 1 
ATOM   863  C CG2 . VAL A 1 115 ? -2.45342  -25.09667 26.77462  1.000 61.62680  ? 111 VAL H CG2 1 
ATOM   864  N N   . PHE A 1 116 ? -5.70270  -26.10635 29.99082  1.000 51.12718  ? 112 PHE H N   1 
ATOM   865  C CA  . PHE A 1 116 ? -6.48962  -26.02285 31.21365  1.000 58.52219  ? 112 PHE H CA  1 
ATOM   866  C C   . PHE A 1 116 ? -5.90116  -26.89329 32.31127  1.000 48.65695  ? 112 PHE H C   1 
ATOM   867  O O   . PHE A 1 116 ? -5.51612  -28.03958 32.06417  1.000 49.14806  ? 112 PHE H O   1 
ATOM   868  C CB  . PHE A 1 116 ? -7.94189  -26.43066 30.96067  1.000 51.97816  ? 112 PHE H CB  1 
ATOM   869  C CG  . PHE A 1 116 ? -8.12494  -27.89190 30.68231  1.000 49.35969  ? 112 PHE H CG  1 
ATOM   870  C CD1 . PHE A 1 116 ? -7.82395  -28.40782 29.43767  1.000 56.23794  ? 112 PHE H CD1 1 
ATOM   871  C CD2 . PHE A 1 116 ? -8.61676  -28.74537 31.65771  1.000 43.51087  ? 112 PHE H CD2 1 
ATOM   872  C CE1 . PHE A 1 116 ? -7.99974  -29.74604 29.16282  1.000 51.94197  ? 112 PHE H CE1 1 
ATOM   873  C CE2 . PHE A 1 116 ? -8.79845  -30.08906 31.38933  1.000 51.53240  ? 112 PHE H CE2 1 
ATOM   874  C CZ  . PHE A 1 116 ? -8.48818  -30.58886 30.13395  1.000 53.45093  ? 112 PHE H CZ  1 
ATOM   875  N N   . ASN A 1 117 ? -5.86861  -26.35184 33.52774  1.000 47.08403  ? 113 ASN H N   1 
ATOM   876  C CA  . ASN A 1 117 ? -5.52658  -27.11668 34.71846  1.000 57.07413  ? 113 ASN H CA  1 
ATOM   877  C C   . ASN A 1 117 ? -6.75268  -27.67621 35.43470  1.000 62.69227  ? 113 ASN H C   1 
ATOM   878  O O   . ASN A 1 117 ? -6.59761  -28.49441 36.35080  1.000 67.99120  ? 113 ASN H O   1 
ATOM   879  C CB  . ASN A 1 117 ? -4.72232  -26.23927 35.68104  1.000 45.86712  ? 113 ASN H CB  1 
ATOM   880  C CG  . ASN A 1 117 ? -5.45034  -24.95431 36.03196  1.000 70.31106  ? 113 ASN H CG  1 
ATOM   881  O OD1 . ASN A 1 117 ? -5.44460  -23.99081 35.26261  1.000 73.67378  ? 113 ASN H OD1 1 
ATOM   882  N ND2 . ASN A 1 117 ? -6.09628  -24.93888 37.19170  1.000 72.00621  ? 113 ASN H ND2 1 
ATOM   883  N N   . GLN A 1 118 ? -7.95707  -27.25879 35.04066  1.000 61.73620  ? 114 GLN H N   1 
ATOM   884  C CA  . GLN A 1 118 ? -9.19997  -27.73181 35.64256  1.000 53.32402  ? 114 GLN H CA  1 
ATOM   885  C C   . GLN A 1 118 ? -10.35164 -27.40718 34.70326  1.000 51.92652  ? 114 GLN H C   1 
ATOM   886  O O   . GLN A 1 118 ? -10.19691 -26.65293 33.74191  1.000 58.12161  ? 114 GLN H O   1 
ATOM   887  C CB  . GLN A 1 118 ? -9.43845  -27.09018 37.00716  1.000 53.02425  ? 114 GLN H CB  1 
ATOM   888  C CG  . GLN A 1 118 ? -9.44459  -25.58385 36.94037  1.000 51.04873  ? 114 GLN H CG  1 
ATOM   889  C CD  . GLN A 1 118 ? -9.65555  -24.94556 38.28883  1.000 56.44438  ? 114 GLN H CD  1 
ATOM   890  O OE1 . GLN A 1 118 ? -8.92036  -24.03906 38.67739  1.000 62.02133  ? 114 GLN H OE1 1 
ATOM   891  N NE2 . GLN A 1 118 ? -10.67058 -25.40727 39.01235  1.000 55.79593  ? 114 GLN H NE2 1 
ATOM   892  N N   . ILE A 1 119 ? -11.51597 -27.98232 35.00113  1.000 53.09299  ? 115 ILE H N   1 
ATOM   893  C CA  . ILE A 1 119 ? -12.75200 -27.72872 34.26410  1.000 46.05961  ? 115 ILE H CA  1 
ATOM   894  C C   . ILE A 1 119 ? -13.84001 -27.43802 35.28586  1.000 53.40356  ? 115 ILE H C   1 
ATOM   895  O O   . ILE A 1 119 ? -14.33941 -28.35682 35.94815  1.000 51.45427  ? 115 ILE H O   1 
ATOM   896  C CB  . ILE A 1 119 ? -13.16381 -28.90447 33.37303  1.000 49.71796  ? 115 ILE H CB  1 
ATOM   897  C CG1 . ILE A 1 119 ? -12.07000 -29.23478 32.36751  1.000 50.82864  ? 115 ILE H CG1 1 
ATOM   898  C CG2 . ILE A 1 119 ? -14.45653 -28.57136 32.64562  1.000 52.88959  ? 115 ILE H CG2 1 
ATOM   899  C CD1 . ILE A 1 119 ? -11.98614 -28.26734 31.22010  1.000 53.78649  ? 115 ILE H CD1 1 
ATOM   900  N N   . LYS A 1 120 ? -14.22486 -26.17385 35.40218  1.000 50.28747  ? 116 LYS H N   1 
ATOM   901  C CA  . LYS A 1 120 ? -15.21073 -25.75316 36.38651  1.000 49.70524  ? 116 LYS H CA  1 
ATOM   902  C C   . LYS A 1 120 ? -16.30798 -24.96952 35.68450  1.000 42.01447  ? 116 LYS H C   1 
ATOM   903  O O   . LYS A 1 120 ? -16.03069 -23.96001 35.03082  1.000 43.31699  ? 116 LYS H O   1 
ATOM   904  C CB  . LYS A 1 120 ? -14.55262 -24.90914 37.48048  1.000 47.14494  ? 116 LYS H CB  1 
ATOM   905  C CG  . LYS A 1 120 ? -15.41067 -24.71754 38.70780  1.000 49.08247  ? 116 LYS H CG  1 
ATOM   906  C CD  . LYS A 1 120 ? -14.67653 -23.92256 39.76689  1.000 46.44186  ? 116 LYS H CD  1 
ATOM   907  C CE  . LYS A 1 120 ? -15.38055 -24.03809 41.10936  1.000 67.14798  ? 116 LYS H CE  1 
ATOM   908  N NZ  . LYS A 1 120 ? -16.85200 -23.82419 40.98604  1.000 68.32830  ? 116 LYS H NZ  1 
ATOM   909  N N   . GLY A 1 121 ? -17.54561 -25.43226 35.81714  1.000 50.88082  ? 117 GLY H N   1 
ATOM   910  C CA  . GLY A 1 121 ? -18.68270 -24.73015 35.26723  1.000 40.07177  ? 117 GLY H CA  1 
ATOM   911  C C   . GLY A 1 121 ? -18.91760 -23.42090 35.99391  1.000 40.80497  ? 117 GLY H C   1 
ATOM   912  O O   . GLY A 1 121 ? -18.40300 -23.19276 37.09645  1.000 42.73471  ? 117 GLY H O   1 
ATOM   913  N N   . PRO A 1 122 ? -19.68917 -22.52672 35.38579  1.000 39.95670  ? 118 PRO H N   1 
ATOM   914  C CA  . PRO A 1 122 ? -19.91031 -21.20933 35.98020  1.000 39.80371  ? 118 PRO H CA  1 
ATOM   915  C C   . PRO A 1 122 ? -21.08071 -21.19802 36.95409  1.000 51.90309  ? 118 PRO H C   1 
ATOM   916  O O   . PRO A 1 122 ? -21.98238 -22.03821 36.90385  1.000 37.69283  ? 118 PRO H O   1 
ATOM   917  C CB  . PRO A 1 122 ? -20.21237 -20.33284 34.75961  1.000 32.85377  ? 118 PRO H CB  1 
ATOM   918  C CG  . PRO A 1 122 ? -20.88680 -21.26489 33.81317  1.000 40.94745  ? 118 PRO H CG  1 
ATOM   919  C CD  . PRO A 1 122 ? -20.29007 -22.63607 34.04584  1.000 42.20612  ? 118 PRO H CD  1 
ATOM   920  N N   . SER A 1 123 ? -21.02507 -20.22424 37.86265  1.000 44.05488  ? 119 SER H N   1 
ATOM   921  C CA  . SER A 1 123 ? -22.13904 -19.83856 38.71954  1.000 46.98659  ? 119 SER H CA  1 
ATOM   922  C C   . SER A 1 123 ? -22.70060 -18.51946 38.20028  1.000 46.68805  ? 119 SER H C   1 
ATOM   923  O O   . SER A 1 123 ? -21.95757 -17.54726 38.03270  1.000 49.17907  ? 119 SER H O   1 
ATOM   924  C CB  . SER A 1 123 ? -21.69472 -19.69838 40.17457  1.000 35.01506  ? 119 SER H CB  1 
ATOM   925  O OG  . SER A 1 123 ? -21.31558 -20.94621 40.71444  1.000 48.88047  ? 119 SER H OG  1 
ATOM   926  N N   . VAL A 1 124 ? -24.00052 -18.48660 37.93723  1.000 41.69969  ? 120 VAL H N   1 
ATOM   927  C CA  . VAL A 1 124 ? -24.65590 -17.31837 37.36136  1.000 44.28618  ? 120 VAL H CA  1 
ATOM   928  C C   . VAL A 1 124 ? -25.58170 -16.71785 38.41455  1.000 47.39167  ? 120 VAL H C   1 
ATOM   929  O O   . VAL A 1 124 ? -26.51409 -17.38421 38.88416  1.000 50.29021  ? 120 VAL H O   1 
ATOM   930  C CB  . VAL A 1 124 ? -25.42462 -17.68311 36.08227  1.000 41.82518  ? 120 VAL H CB  1 
ATOM   931  C CG1 . VAL A 1 124 ? -25.96244 -16.43542 35.40802  1.000 40.80664  ? 120 VAL H CG1 1 
ATOM   932  C CG2 . VAL A 1 124 ? -24.52753 -18.47377 35.12377  1.000 44.29851  ? 120 VAL H CG2 1 
ATOM   933  N N   . PHE A 1 125 ? -25.32442 -15.45824 38.78118  1.000 39.62670  ? 121 PHE H N   1 
ATOM   934  C CA  . PHE A 1 125 ? -26.11302 -14.68913 39.73068  1.000 42.85016  ? 121 PHE H CA  1 
ATOM   935  C C   . PHE A 1 125 ? -26.73880 -13.48608 39.04076  1.000 52.51113  ? 121 PHE H C   1 
ATOM   936  O O   . PHE A 1 125 ? -26.19124 -12.97789 38.05789  1.000 57.67307  ? 121 PHE H O   1 
ATOM   937  C CB  . PHE A 1 125 ? -25.26758 -14.19789 40.90904  1.000 44.25331  ? 121 PHE H CB  1 
ATOM   938  C CG  . PHE A 1 125 ? -24.50425 -15.28426 41.58327  1.000 51.78152  ? 121 PHE H CG  1 
ATOM   939  C CD1 . PHE A 1 125 ? -25.17094 -16.29211 42.25266  1.000 53.06840  ? 121 PHE H CD1 1 
ATOM   940  C CD2 . PHE A 1 125 ? -23.12244 -15.30665 41.53850  1.000 44.67020  ? 121 PHE H CD2 1 
ATOM   941  C CE1 . PHE A 1 125 ? -24.47655 -17.30076 42.86885  1.000 50.57523  ? 121 PHE H CE1 1 
ATOM   942  C CE2 . PHE A 1 125 ? -22.41796 -16.31379 42.15391  1.000 42.86201  ? 121 PHE H CE2 1 
ATOM   943  C CZ  . PHE A 1 125 ? -23.09458 -17.31177 42.81897  1.000 56.85289  ? 121 PHE H CZ  1 
ATOM   944  N N   . PRO A 1 126 ? -27.87254 -12.99928 39.53579  1.000 47.93580  ? 122 PRO H N   1 
ATOM   945  C CA  . PRO A 1 126 ? -28.56306 -11.91073 38.84781  1.000 42.32803  ? 122 PRO H CA  1 
ATOM   946  C C   . PRO A 1 126 ? -27.99667 -10.55114 39.21321  1.000 39.01188  ? 122 PRO H C   1 
ATOM   947  O O   . PRO A 1 126 ? -27.49299 -10.32686 40.31359  1.000 35.37270  ? 122 PRO H O   1 
ATOM   948  C CB  . PRO A 1 126 ? -30.00622 -12.04767 39.34660  1.000 30.95794  ? 122 PRO H CB  1 
ATOM   949  C CG  . PRO A 1 126 ? -29.85527 -12.58364 40.71631  1.000 29.82222  ? 122 PRO H CG  1 
ATOM   950  C CD  . PRO A 1 126 ? -28.66307 -13.51358 40.66870  1.000 44.23518  ? 122 PRO H CD  1 
ATOM   951  N N   . LEU A 1 127 ? -28.09435 -9.63811  38.25948  1.000 36.35814  ? 123 LEU H N   1 
ATOM   952  C CA  . LEU A 1 127 ? -27.82337 -8.21628  38.45590  1.000 38.99462  ? 123 LEU H CA  1 
ATOM   953  C C   . LEU A 1 127 ? -29.18347 -7.52066  38.37124  1.000 41.09621  ? 123 LEU H C   1 
ATOM   954  O O   . LEU A 1 127 ? -29.60832 -7.07415  37.30356  1.000 41.41633  ? 123 LEU H O   1 
ATOM   955  C CB  . LEU A 1 127 ? -26.82056 -7.69567  37.41164  1.000 40.13917  ? 123 LEU H CB  1 
ATOM   956  C CG  . LEU A 1 127 ? -25.42814 -8.32115  37.55663  1.000 39.60367  ? 123 LEU H CG  1 
ATOM   957  C CD1 . LEU A 1 127 ? -24.51416 -7.95096  36.40312  1.000 33.90992  ? 123 LEU H CD1 1 
ATOM   958  C CD2 . LEU A 1 127 ? -24.80776 -7.90671  38.89002  1.000 29.83987  ? 123 LEU H CD2 1 
ATOM   959  N N   . ALA A 1 128 ? -29.86365 -7.44509  39.51235  1.000 46.16420  ? 124 ALA H N   1 
ATOM   960  C CA  . ALA A 1 128 ? -31.27496 -7.08531  39.53564  1.000 48.76680  ? 124 ALA H CA  1 
ATOM   961  C C   . ALA A 1 128 ? -31.46661 -5.64730  39.06329  1.000 47.68162  ? 124 ALA H C   1 
ATOM   962  O O   . ALA A 1 128 ? -30.62398 -4.78984  39.34766  1.000 63.50451  ? 124 ALA H O   1 
ATOM   963  C CB  . ALA A 1 128 ? -31.83378 -7.25474  40.94906  1.000 55.68628  ? 124 ALA H CB  1 
ATOM   964  N N   . PRO A 1 129 ? -32.55172 -5.34605  38.34547  1.000 49.35482  ? 125 PRO H N   1 
ATOM   965  C CA  . PRO A 1 129 ? -32.76658 -3.97477  37.86787  1.000 49.82543  ? 125 PRO H CA  1 
ATOM   966  C C   . PRO A 1 129 ? -32.83335 -2.99487  39.02262  1.000 60.76986  ? 125 PRO H C   1 
ATOM   967  O O   . PRO A 1 129 ? -33.14303 -3.35439  40.15883  1.000 63.25660  ? 125 PRO H O   1 
ATOM   968  C CB  . PRO A 1 129 ? -34.11584 -4.04787  37.14117  1.000 45.66456  ? 125 PRO H CB  1 
ATOM   969  C CG  . PRO A 1 129 ? -34.30569 -5.49271  36.84407  1.000 44.81004  ? 125 PRO H CG  1 
ATOM   970  C CD  . PRO A 1 129 ? -33.63612 -6.25143  37.93350  1.000 50.01519  ? 125 PRO H CD  1 
ATOM   971  N N   . SER A 1 130 ? -32.54471 -1.73570  38.71294  1.000 70.91532  ? 126 SER H N   1 
ATOM   972  C CA  . SER A 1 130 ? -32.64177 -0.68366  39.71362  1.000 73.45665  ? 126 SER H CA  1 
ATOM   973  C C   . SER A 1 130 ? -34.09647 -0.44881  40.09664  1.000 88.96886  ? 126 SER H C   1 
ATOM   974  O O   . SER A 1 130 ? -34.96808 -0.35051  39.22385  1.000 79.54437  ? 126 SER H O   1 
ATOM   975  C CB  . SER A 1 130 ? -32.02746 0.60638   39.18363  1.000 71.11987  ? 126 SER H CB  1 
ATOM   976  O OG  . SER A 1 130 ? -32.15898 1.64034   40.14088  1.000 69.17301  ? 126 SER H OG  1 
ATOM   977  N N   . SER A 1 131 ? -34.35813 -0.37073  41.41035  1.000 92.79657  ? 127 SER H N   1 
ATOM   978  C CA  . SER A 1 131 ? -35.67270 0.05235   41.88529  1.000 91.64142  ? 127 SER H CA  1 
ATOM   979  C C   . SER A 1 131 ? -35.85206 1.56213   41.75356  1.000 91.36651  ? 127 SER H C   1 
ATOM   980  O O   . SER A 1 131 ? -36.98082 2.03817   41.58056  1.000 83.43513  ? 127 SER H O   1 
ATOM   981  C CB  . SER A 1 131 ? -35.89347 -0.40320  43.33704  1.000 88.13248  ? 127 SER H CB  1 
ATOM   982  O OG  . SER A 1 131 ? -34.98235 0.19168   44.25095  1.000 83.67671  ? 127 SER H OG  1 
ATOM   983  N N   . LYS A 1 132 ? -34.75210 2.31831   41.79169  1.000 101.59513 ? 128 LYS H N   1 
ATOM   984  C CA  . LYS A 1 132 ? -34.75475 3.76413   41.59637  1.000 89.16722  ? 128 LYS H CA  1 
ATOM   985  C C   . LYS A 1 132 ? -34.93001 4.16683   40.13123  1.000 85.41962  ? 128 LYS H C   1 
ATOM   986  O O   . LYS A 1 132 ? -34.68112 5.32823   39.78706  1.000 86.40124  ? 128 LYS H O   1 
ATOM   987  C CB  . LYS A 1 132 ? -33.45794 4.37190   42.15928  1.000 76.85450  ? 128 LYS H CB  1 
ATOM   988  C CG  . LYS A 1 132 ? -33.15268 4.00714   43.62922  1.000 75.41547  ? 128 LYS H CG  1 
ATOM   989  C CD  . LYS A 1 132 ? -34.21605 4.54634   44.60761  1.000 80.17420  ? 128 LYS H CD  1 
ATOM   990  C CE  . LYS A 1 132 ? -33.96314 4.11245   46.05779  1.000 68.10859  ? 128 LYS H CE  1 
ATOM   991  N NZ  . LYS A 1 132 ? -34.87631 4.77331   47.03791  1.000 64.03652  ? 128 LYS H NZ  1 
ATOM   992  N N   . SER A 1 133 ? -35.34252 3.24368   39.26715  1.000 95.16364  ? 129 SER H N   1 
ATOM   993  C CA  . SER A 1 133 ? -35.57290 3.55109   37.85872  1.000 84.49010  ? 129 SER H CA  1 
ATOM   994  C C   . SER A 1 133 ? -37.06993 3.58449   37.55507  1.000 100.82393 ? 129 SER H C   1 
ATOM   995  O O   . SER A 1 133 ? -37.49271 4.06336   36.49891  1.000 108.53249 ? 129 SER H O   1 
ATOM   996  C CB  . SER A 1 133 ? -34.86691 2.53036   36.96179  1.000 74.17161  ? 129 SER H CB  1 
ATOM   997  O OG  . SER A 1 133 ? -35.21843 1.20045   37.31494  1.000 66.59656  ? 129 SER H OG  1 
ATOM   998  N N   . GLY A 1 136 ? -39.37998 6.36333   34.99572  1.000 62.87056  ? 132 GLY H N   1 
ATOM   999  C CA  . GLY A 1 136 ? -39.94913 5.92004   33.73517  1.000 79.18775  ? 132 GLY H CA  1 
ATOM   1000 C C   . GLY A 1 136 ? -38.95831 5.95774   32.58747  1.000 94.54192  ? 132 GLY H C   1 
ATOM   1001 O O   . GLY A 1 136 ? -39.34730 6.02842   31.42167  1.000 100.89911 ? 132 GLY H O   1 
ATOM   1002 N N   . GLY A 1 137 ? -37.66937 5.90704   32.91847  1.000 88.35684  ? 133 GLY H N   1 
ATOM   1003 C CA  . GLY A 1 137 ? -36.62934 5.97225   31.90844  1.000 80.88022  ? 133 GLY H CA  1 
ATOM   1004 C C   . GLY A 1 137 ? -36.08043 4.61747   31.50959  1.000 80.53941  ? 133 GLY H C   1 
ATOM   1005 O O   . GLY A 1 137 ? -36.84329 3.70312   31.17643  1.000 71.86290  ? 133 GLY H O   1 
ATOM   1006 N N   . THR A 1 138 ? -34.75644 4.47805   31.54258  1.000 76.60336  ? 134 THR H N   1 
ATOM   1007 C CA  . THR A 1 138 ? -34.07683 3.24796   31.16316  1.000 56.19336  ? 134 THR H CA  1 
ATOM   1008 C C   . THR A 1 138 ? -33.47538 2.60747   32.40495  1.000 65.53872  ? 134 THR H C   1 
ATOM   1009 O O   . THR A 1 138 ? -32.87435 3.29702   33.23468  1.000 74.99262  ? 134 THR H O   1 
ATOM   1010 C CB  . THR A 1 138 ? -32.98895 3.52125   30.12451  1.000 62.19677  ? 134 THR H CB  1 
ATOM   1011 O OG1 . THR A 1 138 ? -33.51286 4.37191   29.09611  1.000 66.04559  ? 134 THR H OG1 1 
ATOM   1012 C CG2 . THR A 1 138 ? -32.51235 2.21836   29.49935  1.000 64.56263  ? 134 THR H CG2 1 
ATOM   1013 N N   . ALA A 1 139 ? -33.65570 1.29883   32.53881  1.000 58.55388  ? 135 ALA H N   1 
ATOM   1014 C CA  . ALA A 1 139 ? -33.05620 0.52834   33.61422  1.000 52.39494  ? 135 ALA H CA  1 
ATOM   1015 C C   . ALA A 1 139 ? -31.94273 -0.36506  33.07744  1.000 56.09555  ? 135 ALA H C   1 
ATOM   1016 O O   . ALA A 1 139 ? -31.87961 -0.67803  31.88498  1.000 48.75516  ? 135 ALA H O   1 
ATOM   1017 C CB  . ALA A 1 139 ? -34.11146 -0.31922  34.32687  1.000 50.16683  ? 135 ALA H CB  1 
ATOM   1018 N N   . ALA A 1 140 ? -31.06162 -0.78358  33.98022  1.000 44.38049  ? 136 ALA H N   1 
ATOM   1019 C CA  . ALA A 1 140 ? -29.99639 -1.72196  33.65917  1.000 42.79091  ? 136 ALA H CA  1 
ATOM   1020 C C   . ALA A 1 140 ? -30.22900 -3.00978  34.43120  1.000 43.63393  ? 136 ALA H C   1 
ATOM   1021 O O   . ALA A 1 140 ? -30.63176 -2.97185  35.59622  1.000 45.98462  ? 136 ALA H O   1 
ATOM   1022 C CB  . ALA A 1 140 ? -28.62298 -1.14597  33.99885  1.000 46.68819  ? 136 ALA H CB  1 
ATOM   1023 N N   . LEU A 1 141 ? -29.99429 -4.14247  33.77439  1.000 44.70259  ? 137 LEU H N   1 
ATOM   1024 C CA  . LEU A 1 141 ? -30.03571 -5.45369  34.40825  1.000 42.79060  ? 137 LEU H CA  1 
ATOM   1025 C C   . LEU A 1 141 ? -28.99264 -6.33714  33.73520  1.000 41.42640  ? 137 LEU H C   1 
ATOM   1026 O O   . LEU A 1 141 ? -28.40373 -5.96637  32.71508  1.000 41.73264  ? 137 LEU H O   1 
ATOM   1027 C CB  . LEU A 1 141 ? -31.43407 -6.07616  34.31709  1.000 39.88745  ? 137 LEU H CB  1 
ATOM   1028 C CG  . LEU A 1 141 ? -31.97299 -6.44298  32.93123  1.000 34.79141  ? 137 LEU H CG  1 
ATOM   1029 C CD1 . LEU A 1 141 ? -31.77627 -7.92796  32.64608  1.000 41.95422  ? 137 LEU H CD1 1 
ATOM   1030 C CD2 . LEU A 1 141 ? -33.44224 -6.08054  32.82685  1.000 44.22097  ? 137 LEU H CD2 1 
ATOM   1031 N N   . GLY A 1 142 ? -28.75795 -7.51537  34.29927  1.000 33.94438  ? 138 GLY H N   1 
ATOM   1032 C CA  . GLY A 1 142 ? -27.76348 -8.38888  33.71463  1.000 46.50379  ? 138 GLY H CA  1 
ATOM   1033 C C   . GLY A 1 142 ? -27.51078 -9.62376  34.55486  1.000 43.21812  ? 138 GLY H C   1 
ATOM   1034 O O   . GLY A 1 142 ? -28.25983 -9.94005  35.48333  1.000 37.84434  ? 138 GLY H O   1 
ATOM   1035 N N   . CYS A 1 143 ? -26.43733 -10.32381 34.18534  1.000 40.03635  ? 139 CYS H N   1 
ATOM   1036 C CA  A CYS A 1 143 ? -26.02348 -11.56556 34.82509  0.905 40.27036  ? 139 CYS H CA  1 
ATOM   1037 C CA  B CYS A 1 143 ? -26.02782 -11.53105 34.87782  0.095 40.75053  ? 139 CYS H CA  1 
ATOM   1038 C C   . CYS A 1 143 ? -24.54016 -11.49142 35.16658  1.000 47.72659  ? 139 CYS H C   1 
ATOM   1039 O O   . CYS A 1 143 ? -23.74564 -10.93466 34.40366  1.000 48.86923  ? 139 CYS H O   1 
ATOM   1040 C CB  A CYS A 1 143 ? -26.30585 -12.79565 33.91293  0.905 45.13225  ? 139 CYS H CB  1 
ATOM   1041 C CB  B CYS A 1 143 ? -26.32820 -12.77800 34.07639  0.095 45.04945  ? 139 CYS H CB  1 
ATOM   1042 S SG  A CYS A 1 143 ? -28.06099 -13.29621 33.88067  0.905 43.80541  ? 139 CYS H SG  1 
ATOM   1043 S SG  B CYS A 1 143 ? -25.42665 -12.89376 32.52307  0.095 43.54710  ? 139 CYS H SG  1 
ATOM   1044 N N   . LEU A 1 144 ? -24.17865 -12.07932 36.29803  1.000 46.88775  ? 140 LEU H N   1 
ATOM   1045 C CA  . LEU A 1 144 ? -22.79522 -12.21310 36.72863  1.000 37.62012  ? 140 LEU H CA  1 
ATOM   1046 C C   . LEU A 1 144 ? -22.40067 -13.66742 36.51662  1.000 48.66217  ? 140 LEU H C   1 
ATOM   1047 O O   . LEU A 1 144 ? -22.98290 -14.56566 37.13312  1.000 50.53364  ? 140 LEU H O   1 
ATOM   1048 C CB  . LEU A 1 144 ? -22.63913 -11.80050 38.18971  1.000 37.23642  ? 140 LEU H CB  1 
ATOM   1049 C CG  . LEU A 1 144 ? -21.28005 -11.99780 38.86263  1.000 42.39014  ? 140 LEU H CG  1 
ATOM   1050 C CD1 . LEU A 1 144 ? -20.15444 -11.32567 38.07216  1.000 29.52372  ? 140 LEU H CD1 1 
ATOM   1051 C CD2 . LEU A 1 144 ? -21.35250 -11.44479 40.27529  1.000 30.97745  ? 140 LEU H CD2 1 
ATOM   1052 N N   . VAL A 1 145 ? -21.44153 -13.90035 35.62504  1.000 44.13195  ? 141 VAL H N   1 
ATOM   1053 C CA  . VAL A 1 145 ? -20.92629 -15.23702 35.34799  1.000 42.06293  ? 141 VAL H CA  1 
ATOM   1054 C C   . VAL A 1 145 ? -19.60008 -15.35134 36.08743  1.000 52.90283  ? 141 VAL H C   1 
ATOM   1055 O O   . VAL A 1 145 ? -18.58572 -14.80103 35.64887  1.000 56.29924  ? 141 VAL H O   1 
ATOM   1056 C CB  . VAL A 1 145 ? -20.76280 -15.48882 33.84893  1.000 37.58932  ? 141 VAL H CB  1 
ATOM   1057 C CG1 . VAL A 1 145 ? -20.35868 -16.93057 33.61843  1.000 39.04717  ? 141 VAL H CG1 1 
ATOM   1058 C CG2 . VAL A 1 145 ? -22.05644 -15.16251 33.12112  1.000 45.09682  ? 141 VAL H CG2 1 
ATOM   1059 N N   . LYS A 1 146 ? -19.60414 -16.06217 37.21587  1.000 46.74246  ? 142 LYS H N   1 
ATOM   1060 C CA  . LYS A 1 146 ? -18.48126 -16.06738 38.14009  1.000 47.85664  ? 142 LYS H CA  1 
ATOM   1061 C C   . LYS A 1 146 ? -17.88172 -17.46105 38.26951  1.000 45.51794  ? 142 LYS H C   1 
ATOM   1062 O O   . LYS A 1 146 ? -18.59741 -18.46780 38.21255  1.000 45.63831  ? 142 LYS H O   1 
ATOM   1063 C CB  . LYS A 1 146 ? -18.91353 -15.56256 39.51716  1.000 38.58234  ? 142 LYS H CB  1 
ATOM   1064 C CG  . LYS A 1 146 ? -17.80930 -14.89182 40.26655  1.000 44.21985  ? 142 LYS H CG  1 
ATOM   1065 C CD  . LYS A 1 146 ? -18.06591 -14.89227 41.73707  1.000 48.55324  ? 142 LYS H CD  1 
ATOM   1066 C CE  . LYS A 1 146 ? -16.78821 -14.55800 42.48698  1.000 39.13559  ? 142 LYS H CE  1 
ATOM   1067 N NZ  . LYS A 1 146 ? -16.99998 -14.72817 43.96122  1.000 78.08081  ? 142 LYS H NZ  1 
ATOM   1068 N N   . ASP A 1 147 ? -16.55473 -17.50003 38.41745  1.000 49.05988  ? 143 ASP H N   1 
ATOM   1069 C CA  . ASP A 1 147 ? -15.81513 -18.67329 38.88667  1.000 46.77345  ? 143 ASP H CA  1 
ATOM   1070 C C   . ASP A 1 147 ? -16.01979 -19.86922 37.95085  1.000 43.00990  ? 143 ASP H C   1 
ATOM   1071 O O   . ASP A 1 147 ? -16.59193 -20.89889 38.30691  1.000 54.00262  ? 143 ASP H O   1 
ATOM   1072 C CB  . ASP A 1 147 ? -16.21087 -19.00384 40.33184  1.000 37.91535  ? 143 ASP H CB  1 
ATOM   1073 C CG  . ASP A 1 147 ? -15.92683 -17.85352 41.28299  1.000 45.18254  ? 143 ASP H CG  1 
ATOM   1074 O OD1 . ASP A 1 147 ? -15.23112 -16.90643 40.86052  1.000 47.56502  ? 143 ASP H OD1 1 
ATOM   1075 O OD2 . ASP A 1 147 ? -16.39383 -17.88070 42.44522  1.000 41.60624  ? 143 ASP H OD2 1 
ATOM   1076 N N   . TYR A 1 148 ? -15.51551 -19.69663 36.73150  1.000 43.49877  ? 144 TYR H N   1 
ATOM   1077 C CA  . TYR A 1 148 ? -15.50415 -20.75894 35.73568  1.000 41.35417  ? 144 TYR H CA  1 
ATOM   1078 C C   . TYR A 1 148 ? -14.11284 -20.85237 35.10679  1.000 47.59501  ? 144 TYR H C   1 
ATOM   1079 O O   . TYR A 1 148 ? -13.28721 -19.94150 35.22694  1.000 41.44736  ? 144 TYR H O   1 
ATOM   1080 C CB  . TYR A 1 148 ? -16.58743 -20.53413 34.66433  1.000 32.21280  ? 144 TYR H CB  1 
ATOM   1081 C CG  . TYR A 1 148 ? -16.33721 -19.36263 33.74847  1.000 41.43170  ? 144 TYR H CG  1 
ATOM   1082 C CD1 . TYR A 1 148 ? -16.75210 -18.07790 34.08891  1.000 42.89787  ? 144 TYR H CD1 1 
ATOM   1083 C CD2 . TYR A 1 148 ? -15.68911 -19.53948 32.53164  1.000 42.61949  ? 144 TYR H CD2 1 
ATOM   1084 C CE1 . TYR A 1 148 ? -16.52431 -17.00357 33.24394  1.000 40.50476  ? 144 TYR H CE1 1 
ATOM   1085 C CE2 . TYR A 1 148 ? -15.45795 -18.47216 31.68703  1.000 50.82129  ? 144 TYR H CE2 1 
ATOM   1086 C CZ  . TYR A 1 148 ? -15.87290 -17.20962 32.04524  1.000 42.08834  ? 144 TYR H CZ  1 
ATOM   1087 O OH  . TYR A 1 148 ? -15.62604 -16.16561 31.17896  1.000 49.82130  ? 144 TYR H OH  1 
ATOM   1088 N N   . PHE A 1 149 ? -13.85866 -21.97634 34.43591  1.000 38.31580  ? 145 PHE H N   1 
ATOM   1089 C CA  . PHE A 1 149 ? -12.56044 -22.23283 33.83064  1.000 40.00076  ? 145 PHE H CA  1 
ATOM   1090 C C   . PHE A 1 149 ? -12.64997 -23.47117 32.94665  1.000 46.68726  ? 145 PHE H C   1 
ATOM   1091 O O   . PHE A 1 149 ? -13.34168 -24.43436 33.30072  1.000 42.45498  ? 145 PHE H O   1 
ATOM   1092 C CB  . PHE A 1 149 ? -11.48278 -22.41641 34.90582  1.000 52.89018  ? 145 PHE H CB  1 
ATOM   1093 C CG  . PHE A 1 149 ? -10.07751 -22.26709 34.38925  1.000 53.15663  ? 145 PHE H CG  1 
ATOM   1094 C CD1 . PHE A 1 149 ? -9.45097  -23.31630 33.73939  1.000 49.37134  ? 145 PHE H CD1 1 
ATOM   1095 C CD2 . PHE A 1 149 ? -9.38371  -21.07882 34.55742  1.000 47.03921  ? 145 PHE H CD2 1 
ATOM   1096 C CE1 . PHE A 1 149 ? -8.16979  -23.17978 33.25057  1.000 48.46563  ? 145 PHE H CE1 1 
ATOM   1097 C CE2 . PHE A 1 149 ? -8.09745  -20.93732 34.07476  1.000 51.06496  ? 145 PHE H CE2 1 
ATOM   1098 C CZ  . PHE A 1 149 ? -7.49020  -21.99120 33.42193  1.000 55.53143  ? 145 PHE H CZ  1 
ATOM   1099 N N   . PRO A 1 150 ? -12.00837 -23.47177 31.76709  1.000 45.89771  ? 146 PRO H N   1 
ATOM   1100 C CA  . PRO A 1 150 ? -11.36892 -22.29336 31.18570  1.000 51.99460  ? 146 PRO H CA  1 
ATOM   1101 C C   . PRO A 1 150 ? -12.34571 -21.49589 30.34031  1.000 53.71711  ? 146 PRO H C   1 
ATOM   1102 O O   . PRO A 1 150 ? -13.51613 -21.86889 30.24166  1.000 50.37621  ? 146 PRO H O   1 
ATOM   1103 C CB  . PRO A 1 150 ? -10.28406 -22.90046 30.30463  1.000 44.18808  ? 146 PRO H CB  1 
ATOM   1104 C CG  . PRO A 1 150 ? -10.95627 -24.12280 29.76603  1.000 45.01884  ? 146 PRO H CG  1 
ATOM   1105 C CD  . PRO A 1 150 ? -11.77022 -24.66617 30.93602  1.000 48.87914  ? 146 PRO H CD  1 
ATOM   1106 N N   . GLU A 1 151 ? -11.85625 -20.42281 29.71712  1.000 55.16642  ? 147 GLU H N   1 
ATOM   1107 C CA  . GLU A 1 151 ? -12.63651 -19.70596 28.72941  1.000 45.83153  ? 147 GLU H CA  1 
ATOM   1108 C C   . GLU A 1 151 ? -12.99760 -20.63822 27.57527  1.000 42.28384  ? 147 GLU H C   1 
ATOM   1109 O O   . GLU A 1 151 ? -12.33916 -21.65885 27.35955  1.000 43.77993  ? 147 GLU H O   1 
ATOM   1110 C CB  . GLU A 1 151 ? -11.85466 -18.50035 28.22151  1.000 40.77888  ? 147 GLU H CB  1 
ATOM   1111 C CG  . GLU A 1 151 ? -11.63927 -17.44330 29.27380  1.000 38.95541  ? 147 GLU H CG  1 
ATOM   1112 C CD  . GLU A 1 151 ? -11.25530 -16.11139 28.67413  1.000 51.79305  ? 147 GLU H CD  1 
ATOM   1113 O OE1 . GLU A 1 151 ? -10.10225 -15.96375 28.20445  1.000 62.13926  ? 147 GLU H OE1 1 
ATOM   1114 O OE2 . GLU A 1 151 ? -12.12195 -15.21293 28.65423  1.000 49.92461  ? 147 GLU H OE2 1 
ATOM   1115 N N   . PRO A 1 152 ? -14.06599 -20.31928 26.82537  1.000 54.00720  ? 148 PRO H N   1 
ATOM   1116 C CA  . PRO A 1 152 ? -14.94635 -19.17686 27.05188  1.000 41.95347  ? 148 PRO H CA  1 
ATOM   1117 C C   . PRO A 1 152 ? -16.35778 -19.57208 27.46663  1.000 47.04800  ? 148 PRO H C   1 
ATOM   1118 O O   . PRO A 1 152 ? -16.74879 -20.73902 27.37959  1.000 36.23381  ? 148 PRO H O   1 
ATOM   1119 C CB  . PRO A 1 152 ? -14.98448 -18.53946 25.68144  1.000 34.52140  ? 148 PRO H CB  1 
ATOM   1120 C CG  . PRO A 1 152 ? -15.12231 -19.76959 24.79941  1.000 30.80830  ? 148 PRO H CG  1 
ATOM   1121 C CD  . PRO A 1 152 ? -14.28002 -20.86287 25.47014  1.000 38.68730  ? 148 PRO H CD  1 
ATOM   1122 N N   . VAL A 1 153 ? -17.12533 -18.57839 27.89822  1.000 47.29125  ? 149 VAL H N   1 
ATOM   1123 C CA  . VAL A 1 153 ? -18.56981 -18.69434 28.02453  1.000 52.94084  ? 149 VAL H CA  1 
ATOM   1124 C C   . VAL A 1 153 ? -19.20310 -17.76916 26.99973  1.000 49.55580  ? 149 VAL H C   1 
ATOM   1125 O O   . VAL A 1 153 ? -18.67953 -16.68543 26.71966  1.000 48.74154  ? 149 VAL H O   1 
ATOM   1126 C CB  . VAL A 1 153 ? -19.06706 -18.34477 29.43941  1.000 46.86092  ? 149 VAL H CB  1 
ATOM   1127 C CG1 . VAL A 1 153 ? -18.67055 -19.42234 30.41857  1.000 47.01632  ? 149 VAL H CG1 1 
ATOM   1128 C CG2 . VAL A 1 153 ? -18.50082 -17.02750 29.86019  1.000 40.82267  ? 149 VAL H CG2 1 
ATOM   1129 N N   . THR A 1 154 ? -20.31259 -18.21378 26.42558  1.000 45.31534  ? 150 THR H N   1 
ATOM   1130 C CA  . THR A 1 154 ? -21.15336 -17.39872 25.56437  1.000 36.46039  ? 150 THR H CA  1 
ATOM   1131 C C   . THR A 1 154 ? -22.40355 -16.99980 26.33458  1.000 52.32282  ? 150 THR H C   1 
ATOM   1132 O O   . THR A 1 154 ? -22.96261 -17.81061 27.07961  1.000 47.08814  ? 150 THR H O   1 
ATOM   1133 C CB  . THR A 1 154 ? -21.56027 -18.16759 24.30915  1.000 38.08662  ? 150 THR H CB  1 
ATOM   1134 O OG1 . THR A 1 154 ? -22.36778 -19.28987 24.68772  1.000 44.35556  ? 150 THR H OG1 1 
ATOM   1135 C CG2 . THR A 1 154 ? -20.34087 -18.66154 23.57432  1.000 36.48196  ? 150 THR H CG2 1 
ATOM   1136 N N   . VAL A 1 155 ? -22.84930 -15.75790 26.15425  1.000 53.81191  ? 151 VAL H N   1 
ATOM   1137 C CA  . VAL A 1 155 ? -24.05416 -15.26667 26.81822  1.000 45.07257  ? 151 VAL H CA  1 
ATOM   1138 C C   . VAL A 1 155 ? -24.99246 -14.67818 25.77275  1.000 46.32429  ? 151 VAL H C   1 
ATOM   1139 O O   . VAL A 1 155 ? -24.60734 -13.77217 25.02331  1.000 41.01854  ? 151 VAL H O   1 
ATOM   1140 C CB  . VAL A 1 155 ? -23.74112 -14.21828 27.89573  1.000 41.50536  ? 151 VAL H CB  1 
ATOM   1141 C CG1 . VAL A 1 155 ? -25.00715 -13.89246 28.66730  1.000 43.51089  ? 151 VAL H CG1 1 
ATOM   1142 C CG2 . VAL A 1 155 ? -22.64059 -14.71409 28.83007  1.000 36.54111  ? 151 VAL H CG2 1 
ATOM   1143 N N   . SER A 1 156 ? -26.21593 -15.18722 25.72513  1.000 40.10953  ? 152 SER H N   1 
ATOM   1144 C CA  . SER A 1 156 ? -27.29258 -14.57693 24.96680  1.000 41.72437  ? 152 SER H CA  1 
ATOM   1145 C C   . SER A 1 156 ? -28.42623 -14.22982 25.92216  1.000 49.53530  ? 152 SER H C   1 
ATOM   1146 O O   . SER A 1 156 ? -28.43599 -14.63270 27.08707  1.000 49.16155  ? 152 SER H O   1 
ATOM   1147 C CB  . SER A 1 156 ? -27.79679 -15.50415 23.85357  1.000 38.58435  ? 152 SER H CB  1 
ATOM   1148 O OG  . SER A 1 156 ? -28.55635 -16.56946 24.40037  1.000 40.08474  ? 152 SER H OG  1 
ATOM   1149 N N   . TRP A 1 157 ? -29.39786 -13.48025 25.41265  1.000 51.34025  ? 153 TRP H N   1 
ATOM   1150 C CA  . TRP A 1 157 ? -30.50216 -12.96984 26.21467  1.000 45.97471  ? 153 TRP H CA  1 
ATOM   1151 C C   . TRP A 1 157 ? -31.83340 -13.37699 25.59774  1.000 46.67584  ? 153 TRP H C   1 
ATOM   1152 O O   . TRP A 1 157 ? -32.11780 -13.05155 24.43793  1.000 40.62072  ? 153 TRP H O   1 
ATOM   1153 C CB  . TRP A 1 157 ? -30.40913 -11.45697 26.34355  1.000 42.42967  ? 153 TRP H CB  1 
ATOM   1154 C CG  . TRP A 1 157 ? -29.40667 -11.04672 27.33960  1.000 45.26264  ? 153 TRP H CG  1 
ATOM   1155 C CD1 . TRP A 1 157 ? -28.11762 -10.67536 27.10501  1.000 45.24034  ? 153 TRP H CD1 1 
ATOM   1156 C CD2 . TRP A 1 157 ? -29.60301 -10.95883 28.74995  1.000 45.18733  ? 153 TRP H CD2 1 
ATOM   1157 N NE1 . TRP A 1 157 ? -27.49937 -10.35423 28.28509  1.000 41.14459  ? 153 TRP H NE1 1 
ATOM   1158 C CE2 . TRP A 1 157 ? -28.39117 -10.52224 29.31138  1.000 40.02951  ? 153 TRP H CE2 1 
ATOM   1159 C CE3 . TRP A 1 157 ? -30.69060 -11.20235 29.59231  1.000 40.30210  ? 153 TRP H CE3 1 
ATOM   1160 C CZ2 . TRP A 1 157 ? -28.23327 -10.32609 30.67746  1.000 46.12518  ? 153 TRP H CZ2 1 
ATOM   1161 C CZ3 . TRP A 1 157 ? -30.53654 -11.00331 30.94125  1.000 45.49472  ? 153 TRP H CZ3 1 
ATOM   1162 C CH2 . TRP A 1 157 ? -29.31435 -10.57522 31.47578  1.000 49.91401  ? 153 TRP H CH2 1 
ATOM   1163 N N   . ASN A 1 158 ? -32.65156 -14.06938 26.38732  1.000 48.36651  ? 154 ASN H N   1 
ATOM   1164 C CA  . ASN A 1 158 ? -33.91960 -14.61704 25.91946  1.000 53.54402  ? 154 ASN H CA  1 
ATOM   1165 C C   . ASN A 1 158 ? -33.70866 -15.43910 24.64983  1.000 59.18362  ? 154 ASN H C   1 
ATOM   1166 O O   . ASN A 1 158 ? -34.33161 -15.19802 23.61283  1.000 58.24211  ? 154 ASN H O   1 
ATOM   1167 C CB  . ASN A 1 158 ? -34.95290 -13.50841 25.70064  1.000 53.55935  ? 154 ASN H CB  1 
ATOM   1168 C CG  . ASN A 1 158 ? -35.28178 -12.76035 26.97928  1.000 49.97176  ? 154 ASN H CG  1 
ATOM   1169 O OD1 . ASN A 1 158 ? -35.05063 -13.25880 28.08307  1.000 50.81378  ? 154 ASN H OD1 1 
ATOM   1170 N ND2 . ASN A 1 158 ? -35.82375 -11.55836 26.83804  1.000 45.79369  ? 154 ASN H ND2 1 
ATOM   1171 N N   . SER A 1 159 ? -32.79048 -16.40457 24.74114  1.000 55.63080  ? 155 SER H N   1 
ATOM   1172 C CA  . SER A 1 159 ? -32.48607 -17.33333 23.65160  1.000 45.36749  ? 155 SER H CA  1 
ATOM   1173 C C   . SER A 1 159 ? -32.30311 -16.60735 22.32065  1.000 43.23774  ? 155 SER H C   1 
ATOM   1174 O O   . SER A 1 159 ? -32.77978 -17.05594 21.27808  1.000 60.06353  ? 155 SER H O   1 
ATOM   1175 C CB  . SER A 1 159 ? -33.56393 -18.40989 23.54129  1.000 43.36973  ? 155 SER H CB  1 
ATOM   1176 O OG  . SER A 1 159 ? -33.93234 -18.88308 24.82529  1.000 49.46661  ? 155 SER H OG  1 
ATOM   1177 N N   . GLY A 1 160 ? -31.62772 -15.46045 22.35967  1.000 49.50128  ? 156 GLY H N   1 
ATOM   1178 C CA  . GLY A 1 160 ? -31.28775 -14.72457 21.16003  1.000 50.13617  ? 156 GLY H CA  1 
ATOM   1179 C C   . GLY A 1 160 ? -32.26676 -13.64299 20.75392  1.000 60.03595  ? 156 GLY H C   1 
ATOM   1180 O O   . GLY A 1 160 ? -31.90499 -12.77929 19.94199  1.000 61.30196  ? 156 GLY H O   1 
ATOM   1181 N N   . ALA A 1 161 ? -33.48829 -13.65558 21.29524  1.000 55.56385  ? 157 ALA H N   1 
ATOM   1182 C CA  . ALA A 1 161 ? -34.48305 -12.65200 20.92513  1.000 58.50803  ? 157 ALA H CA  1 
ATOM   1183 C C   . ALA A 1 161 ? -34.01967 -11.23757 21.26474  1.000 64.08027  ? 157 ALA H C   1 
ATOM   1184 O O   . ALA A 1 161 ? -34.26364 -10.29816 20.49780  1.000 64.20686  ? 157 ALA H O   1 
ATOM   1185 C CB  . ALA A 1 161 ? -35.81355 -12.95784 21.61247  1.000 54.82219  ? 157 ALA H CB  1 
ATOM   1186 N N   . LEU A 1 162 ? -33.35078 -11.06059 22.40007  1.000 59.50512  ? 158 LEU H N   1 
ATOM   1187 C CA  . LEU A 1 162 ? -32.91441 -9.74407  22.84638  1.000 44.44587  ? 158 LEU H CA  1 
ATOM   1188 C C   . LEU A 1 162 ? -31.42815 -9.58352  22.55326  1.000 46.40836  ? 158 LEU H C   1 
ATOM   1189 O O   . LEU A 1 162 ? -30.58600 -10.15696 23.25103  1.000 57.18043  ? 158 LEU H O   1 
ATOM   1190 C CB  . LEU A 1 162 ? -33.21488 -9.56692  24.32930  1.000 45.11901  ? 158 LEU H CB  1 
ATOM   1191 C CG  . LEU A 1 162 ? -32.61269 -8.36674  25.04963  1.000 48.92613  ? 158 LEU H CG  1 
ATOM   1192 C CD1 . LEU A 1 162 ? -32.83986 -7.06555  24.29845  1.000 52.25694  ? 158 LEU H CD1 1 
ATOM   1193 C CD2 . LEU A 1 162 ? -33.20487 -8.29644  26.43884  1.000 32.29845  ? 158 LEU H CD2 1 
ATOM   1194 N N   . THR A 1 163 ? -31.10809 -8.80511  21.51578  1.000 48.93126  ? 159 THR H N   1 
ATOM   1195 C CA  . THR A 1 163 ? -29.72770 -8.50183  21.16483  1.000 44.64480  ? 159 THR H CA  1 
ATOM   1196 C C   . THR A 1 163 ? -29.37519 -7.02944  21.27204  1.000 48.32453  ? 159 THR H C   1 
ATOM   1197 O O   . THR A 1 163 ? -28.18933 -6.70765  21.42018  1.000 44.90469  ? 159 THR H O   1 
ATOM   1198 C CB  . THR A 1 163 ? -29.41015 -8.95835  19.72999  1.000 51.34906  ? 159 THR H CB  1 
ATOM   1199 O OG1 . THR A 1 163 ? -30.09470 -8.11689  18.79491  1.000 53.19581  ? 159 THR H OG1 1 
ATOM   1200 C CG2 . THR A 1 163 ? -29.83854 -10.39777 19.51339  1.000 58.82867  ? 159 THR H CG2 1 
ATOM   1201 N N   . SER A 1 164 ? -30.35258 -6.13217  21.18685  1.000 50.00436  ? 160 SER H N   1 
ATOM   1202 C CA  . SER A 1 164 ? -30.05624 -4.70652  21.19144  1.000 54.45341  ? 160 SER H CA  1 
ATOM   1203 C C   . SER A 1 164 ? -29.71027 -4.21447  22.59336  1.000 47.12798  ? 160 SER H C   1 
ATOM   1204 O O   . SER A 1 164 ? -30.33586 -4.60379  23.58329  1.000 43.58601  ? 160 SER H O   1 
ATOM   1205 C CB  . SER A 1 164 ? -31.24156 -3.92092  20.63532  1.000 54.20750  ? 160 SER H CB  1 
ATOM   1206 O OG  . SER A 1 164 ? -31.02812 -2.52717  20.77003  1.000 75.04148  ? 160 SER H OG  1 
ATOM   1207 N N   . GLY A 1 165 ? -28.70134 -3.34910  22.66911  1.000 50.60498  ? 161 GLY H N   1 
ATOM   1208 C CA  . GLY A 1 165 ? -28.27531 -2.78502  23.93329  1.000 49.51911  ? 161 GLY H CA  1 
ATOM   1209 C C   . GLY A 1 165 ? -27.60646 -3.75057  24.88437  1.000 56.59027  ? 161 GLY H C   1 
ATOM   1210 O O   . GLY A 1 165 ? -27.44702 -3.41788  26.06265  1.000 55.29607  ? 161 GLY H O   1 
ATOM   1211 N N   . VAL A 1 166 ? -27.21639 -4.93540  24.41300  1.000 52.56462  ? 162 VAL H N   1 
ATOM   1212 C CA  . VAL A 1 166 ? -26.57196 -5.94508  25.24526  1.000 43.98380  ? 162 VAL H CA  1 
ATOM   1213 C C   . VAL A 1 166 ? -25.06918 -5.72644  25.20827  1.000 43.52122  ? 162 VAL H C   1 
ATOM   1214 O O   . VAL A 1 166 ? -24.48472 -5.52615  24.13690  1.000 47.90604  ? 162 VAL H O   1 
ATOM   1215 C CB  . VAL A 1 166 ? -26.92451 -7.36396  24.76915  1.000 39.55701  ? 162 VAL H CB  1 
ATOM   1216 C CG1 . VAL A 1 166 ? -26.11478 -8.38886  25.54362  1.000 32.00591  ? 162 VAL H CG1 1 
ATOM   1217 C CG2 . VAL A 1 166 ? -28.41016 -7.62603  24.92124  1.000 35.33106  ? 162 VAL H CG2 1 
ATOM   1218 N N   . HIS A 1 167 ? -24.44281 -5.75557  26.37941  1.000 54.24847  ? 163 HIS H N   1 
ATOM   1219 C CA  . HIS A 1 167 ? -22.99174 -5.69133  26.51096  1.000 39.44776  ? 163 HIS H CA  1 
ATOM   1220 C C   . HIS A 1 167 ? -22.54319 -6.92100  27.27887  1.000 46.04966  ? 163 HIS H C   1 
ATOM   1221 O O   . HIS A 1 167 ? -22.91757 -7.09918  28.44268  1.000 41.11578  ? 163 HIS H O   1 
ATOM   1222 C CB  . HIS A 1 167 ? -22.55766 -4.42168  27.22658  1.000 36.74140  ? 163 HIS H CB  1 
ATOM   1223 C CG  . HIS A 1 167 ? -22.76757 -3.17697  26.42587  1.000 51.96016  ? 163 HIS H CG  1 
ATOM   1224 N ND1 . HIS A 1 167 ? -21.94433 -2.81910  25.38059  1.000 60.85351  ? 163 HIS H ND1 1 
ATOM   1225 C CD2 . HIS A 1 167 ? -23.70025 -2.20028  26.52263  1.000 51.78027  ? 163 HIS H CD2 1 
ATOM   1226 C CE1 . HIS A 1 167 ? -22.36085 -1.67561  24.86693  1.000 58.70642  ? 163 HIS H CE1 1 
ATOM   1227 N NE2 . HIS A 1 167 ? -23.42406 -1.27827  25.54289  1.000 53.91236  ? 163 HIS H NE2 1 
ATOM   1228 N N   . THR A 1 168 ? -21.76414 -7.77238  26.62606  1.000 46.48162  ? 164 THR H N   1 
ATOM   1229 C CA  . THR A 1 168 ? -21.14819 -8.92308  27.27073  1.000 39.91484  ? 164 THR H CA  1 
ATOM   1230 C C   . THR A 1 168 ? -19.65683 -8.62416  27.32541  1.000 39.97332  ? 164 THR H C   1 
ATOM   1231 O O   . THR A 1 168 ? -18.97612 -8.62811  26.29770  1.000 51.80557  ? 164 THR H O   1 
ATOM   1232 C CB  . THR A 1 168 ? -21.46924 -10.20728 26.52341  1.000 36.49583  ? 164 THR H CB  1 
ATOM   1233 O OG1 . THR A 1 168 ? -22.88545 -10.41687 26.55234  1.000 48.53275  ? 164 THR H OG1 1 
ATOM   1234 C CG2 . THR A 1 168 ? -20.79064 -11.38091 27.17668  1.000 38.58322  ? 164 THR H CG2 1 
ATOM   1235 N N   . PHE A 1 169 ? -19.16844 -8.31643  28.52484  1.000 36.73255  ? 165 PHE H N   1 
ATOM   1236 C CA  . PHE A 1 169 ? -17.81594 -7.82509  28.69208  1.000 42.28158  ? 165 PHE H CA  1 
ATOM   1237 C C   . PHE A 1 169 ? -16.79864 -8.94234  28.47586  1.000 47.76213  ? 165 PHE H C   1 
ATOM   1238 O O   . PHE A 1 169 ? -17.12991 -10.12798 28.56153  1.000 44.48669  ? 165 PHE H O   1 
ATOM   1239 C CB  . PHE A 1 169 ? -17.62679 -7.24218  30.09227  1.000 43.85910  ? 165 PHE H CB  1 
ATOM   1240 C CG  . PHE A 1 169 ? -18.38168 -5.96383  30.34287  1.000 43.84921  ? 165 PHE H CG  1 
ATOM   1241 C CD1 . PHE A 1 169 ? -19.65943 -5.98637  30.87307  1.000 43.23250  ? 165 PHE H CD1 1 
ATOM   1242 C CD2 . PHE A 1 169 ? -17.80235 -4.73860  30.08311  1.000 42.35612  ? 165 PHE H CD2 1 
ATOM   1243 C CE1 . PHE A 1 169 ? -20.34853 -4.80935  31.11639  1.000 42.53978  ? 165 PHE H CE1 1 
ATOM   1244 C CE2 . PHE A 1 169 ? -18.49174 -3.56480  30.33294  1.000 51.95672  ? 165 PHE H CE2 1 
ATOM   1245 C CZ  . PHE A 1 169 ? -19.76407 -3.60345  30.85095  1.000 39.23113  ? 165 PHE H CZ  1 
ATOM   1246 N N   . PRO A 1 170 ? -15.54716 -8.58388  28.19087  1.000 49.52381  ? 166 PRO H N   1 
ATOM   1247 C CA  . PRO A 1 170 ? -14.47897 -9.58596  28.21909  1.000 46.72034  ? 166 PRO H CA  1 
ATOM   1248 C C   . PRO A 1 170 ? -14.26279 -10.09323 29.63358  1.000 46.80786  ? 166 PRO H C   1 
ATOM   1249 O O   . PRO A 1 170 ? -14.29692 -9.32719  30.59973  1.000 36.71191  ? 166 PRO H O   1 
ATOM   1250 C CB  . PRO A 1 170 ? -13.24931 -8.81966  27.71008  1.000 39.05380  ? 166 PRO H CB  1 
ATOM   1251 C CG  . PRO A 1 170 ? -13.78915 -7.64025  26.98918  1.000 48.94770  ? 166 PRO H CG  1 
ATOM   1252 C CD  . PRO A 1 170 ? -15.06350 -7.28017  27.70161  1.000 56.79259  ? 166 PRO H CD  1 
ATOM   1253 N N   . ALA A 1 171 ? -14.03174 -11.39710 29.74356  1.000 42.50584  ? 167 ALA H N   1 
ATOM   1254 C CA  . ALA A 1 171 ? -13.76626 -12.00181 31.03661  1.000 42.70559  ? 167 ALA H CA  1 
ATOM   1255 C C   . ALA A 1 171 ? -12.41891 -11.54715 31.58486  1.000 42.67881  ? 167 ALA H C   1 
ATOM   1256 O O   . ALA A 1 171 ? -11.46345 -11.30840 30.84422  1.000 53.12720  ? 167 ALA H O   1 
ATOM   1257 C CB  . ALA A 1 171 ? -13.79611 -13.52549 30.93068  1.000 50.22837  ? 167 ALA H CB  1 
ATOM   1258 N N   . VAL A 1 172 ? -12.35729 -11.41784 32.90183  1.000 42.67630  ? 168 VAL H N   1 
ATOM   1259 C CA  . VAL A 1 172 ? -11.11881 -11.14378 33.61258  1.000 44.55933  ? 168 VAL H CA  1 
ATOM   1260 C C   . VAL A 1 172 ? -10.74380 -12.38005 34.41774  1.000 48.99694  ? 168 VAL H C   1 
ATOM   1261 O O   . VAL A 1 172 ? -11.60502 -13.17362 34.81620  1.000 41.10863  ? 168 VAL H O   1 
ATOM   1262 C CB  . VAL A 1 172 ? -11.25087 -9.91140  34.52848  1.000 52.30109  ? 168 VAL H CB  1 
ATOM   1263 C CG1 . VAL A 1 172 ? -11.86172 -8.75616  33.76117  1.000 49.08274  ? 168 VAL H CG1 1 
ATOM   1264 C CG2 . VAL A 1 172 ? -12.09668 -10.24335 35.75577  1.000 53.00745  ? 168 VAL H CG2 1 
ATOM   1265 N N   . LEU A 1 173 ? -9.44283  -12.54563 34.64842  1.000 56.13607  ? 169 LEU H N   1 
ATOM   1266 C CA  . LEU A 1 173 ? -8.93031  -13.60855 35.50191  1.000 40.91552  ? 169 LEU H CA  1 
ATOM   1267 C C   . LEU A 1 173 ? -8.83429  -13.07027 36.92176  1.000 46.37029  ? 169 LEU H C   1 
ATOM   1268 O O   . LEU A 1 173 ? -8.18501  -12.04604 37.15688  1.000 48.06175  ? 169 LEU H O   1 
ATOM   1269 C CB  . LEU A 1 173 ? -7.56860  -14.09348 35.01246  1.000 52.24608  ? 169 LEU H CB  1 
ATOM   1270 C CG  . LEU A 1 173 ? -7.00154  -15.37301 35.62318  1.000 42.65864  ? 169 LEU H CG  1 
ATOM   1271 C CD1 . LEU A 1 173 ? -7.89775  -16.56010 35.29299  1.000 42.13875  ? 169 LEU H CD1 1 
ATOM   1272 C CD2 . LEU A 1 173 ? -5.61260  -15.59702 35.09213  1.000 35.66786  ? 169 LEU H CD2 1 
ATOM   1273 N N   . GLN A 1 174 ? -9.50579  -13.73929 37.85632  1.000 48.72330  ? 170 GLN H N   1 
ATOM   1274 C CA  . GLN A 1 174 ? -9.49503  -13.33235 39.25174  1.000 43.29622  ? 170 GLN H CA  1 
ATOM   1275 C C   . GLN A 1 174 ? -8.28785  -13.93448 39.96757  1.000 47.12490  ? 170 GLN H C   1 
ATOM   1276 O O   . GLN A 1 174 ? -7.64280  -14.87064 39.48150  1.000 43.49926  ? 170 GLN H O   1 
ATOM   1277 C CB  . GLN A 1 174 ? -10.79017 -13.75724 39.93962  1.000 47.30933  ? 170 GLN H CB  1 
ATOM   1278 C CG  . GLN A 1 174 ? -12.05580 -13.46216 39.13999  1.000 43.92799  ? 170 GLN H CG  1 
ATOM   1279 C CD  . GLN A 1 174 ? -13.26179 -14.23362 39.64975  1.000 44.70338  ? 170 GLN H CD  1 
ATOM   1280 O OE1 . GLN A 1 174 ? -14.10418 -13.69321 40.36844  1.000 53.38297  ? 170 GLN H OE1 1 
ATOM   1281 N NE2 . GLN A 1 174 ? -13.34849 -15.50608 39.27794  1.000 40.60388  ? 170 GLN H NE2 1 
ATOM   1282 N N   . SER A 1 175 ? -7.99169  -13.38870 41.15274  1.000 54.73754  ? 171 SER H N   1 
ATOM   1283 C CA  . SER A 1 175 ? -6.85294  -13.86718 41.93031  1.000 46.43152  ? 171 SER H CA  1 
ATOM   1284 C C   . SER A 1 175 ? -6.96286  -15.35020 42.25935  1.000 54.30510  ? 171 SER H C   1 
ATOM   1285 O O   . SER A 1 175 ? -5.93542  -16.00692 42.46596  1.000 61.86711  ? 171 SER H O   1 
ATOM   1286 C CB  . SER A 1 175 ? -6.72228  -13.05709 43.20998  1.000 41.82653  ? 171 SER H CB  1 
ATOM   1287 O OG  . SER A 1 175 ? -7.89448  -13.19387 43.98730  1.000 65.60192  ? 171 SER H OG  1 
ATOM   1288 N N   . SER A 1 176 ? -8.18336  -15.89049 42.30138  1.000 46.32980  ? 172 SER H N   1 
ATOM   1289 C CA  . SER A 1 176 ? -8.41738  -17.32213 42.46083  1.000 46.59064  ? 172 SER H CA  1 
ATOM   1290 C C   . SER A 1 176 ? -7.96921  -18.14186 41.25757  1.000 55.39387  ? 172 SER H C   1 
ATOM   1291 O O   . SER A 1 176 ? -7.96708  -19.37848 41.33807  1.000 48.89787  ? 172 SER H O   1 
ATOM   1292 C CB  . SER A 1 176 ? -9.90571  -17.57858 42.69282  1.000 47.94937  ? 172 SER H CB  1 
ATOM   1293 O OG  . SER A 1 176 ? -10.63548 -17.38699 41.48751  1.000 47.67558  ? 172 SER H OG  1 
ATOM   1294 N N   . GLY A 1 177 ? -7.61682  -17.49432 40.14625  1.000 51.12432  ? 173 GLY H N   1 
ATOM   1295 C CA  . GLY A 1 177 ? -7.32493  -18.21099 38.92649  1.000 38.30508  ? 173 GLY H CA  1 
ATOM   1296 C C   . GLY A 1 177 ? -8.54508  -18.67391 38.16850  1.000 52.25497  ? 173 GLY H C   1 
ATOM   1297 O O   . GLY A 1 177 ? -8.41550  -19.49787 37.25559  1.000 57.83202  ? 173 GLY H O   1 
ATOM   1298 N N   . LEU A 1 178 ? -9.72621  -18.17810 38.52368  1.000 53.23152  ? 174 LEU H N   1 
ATOM   1299 C CA  . LEU A 1 178 ? -10.95409 -18.43522 37.79193  1.000 48.88838  ? 174 LEU H CA  1 
ATOM   1300 C C   . LEU A 1 178 ? -11.39808 -17.16702 37.07481  1.000 46.60297  ? 174 LEU H C   1 
ATOM   1301 O O   . LEU A 1 178 ? -11.12729 -16.04933 37.52491  1.000 43.01567  ? 174 LEU H O   1 
ATOM   1302 C CB  . LEU A 1 178 ? -12.05838 -18.92744 38.72988  1.000 43.24310  ? 174 LEU H CB  1 
ATOM   1303 C CG  . LEU A 1 178 ? -11.63858 -20.13991 39.55763  1.000 44.98818  ? 174 LEU H CG  1 
ATOM   1304 C CD1 . LEU A 1 178 ? -12.74479 -20.55040 40.48967  1.000 38.16466  ? 174 LEU H CD1 1 
ATOM   1305 C CD2 . LEU A 1 178 ? -11.23114 -21.29662 38.64901  1.000 41.10235  ? 174 LEU H CD2 1 
ATOM   1306 N N   . TYR A 1 179 ? -12.07330 -17.35240 35.94743  1.000 42.15665  ? 175 TYR H N   1 
ATOM   1307 C CA  . TYR A 1 179 ? -12.57545 -16.23854 35.15971  1.000 50.55345  ? 175 TYR H CA  1 
ATOM   1308 C C   . TYR A 1 179 ? -13.94125 -15.77827 35.66538  1.000 47.47072  ? 175 TYR H C   1 
ATOM   1309 O O   . TYR A 1 179 ? -14.66929 -16.51422 36.33391  1.000 44.25018  ? 175 TYR H O   1 
ATOM   1310 C CB  . TYR A 1 179 ? -12.67077 -16.62554 33.68391  1.000 45.06592  ? 175 TYR H CB  1 
ATOM   1311 C CG  . TYR A 1 179 ? -11.33248 -16.82842 33.01120  1.000 45.37705  ? 175 TYR H CG  1 
ATOM   1312 C CD1 . TYR A 1 179 ? -10.50790 -15.74762 32.72211  1.000 49.19587  ? 175 TYR H CD1 1 
ATOM   1313 C CD2 . TYR A 1 179 ? -10.89595 -18.09724 32.65270  1.000 50.86224  ? 175 TYR H CD2 1 
ATOM   1314 C CE1 . TYR A 1 179 ? -9.28273  -15.92538 32.10298  1.000 48.50181  ? 175 TYR H CE1 1 
ATOM   1315 C CE2 . TYR A 1 179 ? -9.67220  -18.27869 32.02755  1.000 57.81133  ? 175 TYR H CE2 1 
ATOM   1316 C CZ  . TYR A 1 179 ? -8.87421  -17.18921 31.75550  1.000 45.39176  ? 175 TYR H CZ  1 
ATOM   1317 O OH  . TYR A 1 179 ? -7.65748  -17.36678 31.14134  1.000 43.95856  ? 175 TYR H OH  1 
ATOM   1318 N N   . SER A 1 180 ? -14.28476 -14.54091 35.31884  1.000 50.88430  ? 176 SER H N   1 
ATOM   1319 C CA  . SER A 1 180 ? -15.54659 -13.93971 35.72043  1.000 42.95254  ? 176 SER H CA  1 
ATOM   1320 C C   . SER A 1 180 ? -15.90800 -12.86650 34.70211  1.000 46.40252  ? 176 SER H C   1 
ATOM   1321 O O   . SER A 1 180 ? -15.04195 -12.11406 34.25644  1.000 42.23500  ? 176 SER H O   1 
ATOM   1322 C CB  . SER A 1 180 ? -15.45112 -13.34745 37.13318  1.000 41.71233  ? 176 SER H CB  1 
ATOM   1323 O OG  . SER A 1 180 ? -16.51138 -12.43661 37.40086  1.000 47.91934  ? 176 SER H OG  1 
ATOM   1324 N N   . LEU A 1 181 ? -17.17929 -12.81157 34.31714  1.000 47.19201  ? 177 LEU H N   1 
ATOM   1325 C CA  . LEU A 1 181 ? -17.61759 -11.74964 33.42720  1.000 47.60234  ? 177 LEU H CA  1 
ATOM   1326 C C   . LEU A 1 181 ? -19.06269 -11.38726 33.73290  1.000 45.51492  ? 177 LEU H C   1 
ATOM   1327 O O   . LEU A 1 181 ? -19.80440 -12.14954 34.35759  1.000 47.05681  ? 177 LEU H O   1 
ATOM   1328 C CB  . LEU A 1 181 ? -17.45328 -12.14564 31.95429  1.000 47.08125  ? 177 LEU H CB  1 
ATOM   1329 C CG  . LEU A 1 181 ? -18.28501 -13.26185 31.32079  1.000 47.70250  ? 177 LEU H CG  1 
ATOM   1330 C CD1 . LEU A 1 181 ? -19.70360 -12.79620 30.95499  1.000 41.71362  ? 177 LEU H CD1 1 
ATOM   1331 C CD2 . LEU A 1 181 ? -17.57713 -13.74763 30.08377  1.000 36.88126  ? 177 LEU H CD2 1 
ATOM   1332 N N   . SER A 1 182 ? -19.46632 -10.21783 33.24903  1.000 44.23141  ? 178 SER H N   1 
ATOM   1333 C CA  . SER A 1 182 ? -20.84561 -9.76764  33.33395  1.000 36.28187  ? 178 SER H CA  1 
ATOM   1334 C C   . SER A 1 182 ? -21.40173 -9.53795  31.93768  1.000 41.56044  ? 178 SER H C   1 
ATOM   1335 O O   . SER A 1 182 ? -20.68677 -9.07726  31.04195  1.000 39.44549  ? 178 SER H O   1 
ATOM   1336 C CB  . SER A 1 182 ? -20.95763 -8.48218  34.15714  1.000 32.62212  ? 178 SER H CB  1 
ATOM   1337 O OG  . SER A 1 182 ? -20.79006 -8.75701  35.54209  1.000 48.07326  ? 178 SER H OG  1 
ATOM   1338 N N   . SER A 1 183 ? -22.67293 -9.88895  31.75499  1.000 45.30619  ? 179 SER H N   1 
ATOM   1339 C CA  . SER A 1 183 ? -23.45447 -9.49015  30.59092  1.000 43.65451  ? 179 SER H CA  1 
ATOM   1340 C C   . SER A 1 183 ? -24.58426 -8.59513  31.07894  1.000 41.10739  ? 179 SER H C   1 
ATOM   1341 O O   . SER A 1 183 ? -25.29005 -8.94589  32.02872  1.000 39.08979  ? 179 SER H O   1 
ATOM   1342 C CB  . SER A 1 183 ? -24.01092 -10.70016 29.84225  1.000 43.57722  ? 179 SER H CB  1 
ATOM   1343 O OG  . SER A 1 183 ? -24.62855 -10.30059 28.63274  1.000 47.95005  ? 179 SER H OG  1 
ATOM   1344 N N   . VAL A 1 184 ? -24.73038 -7.42780  30.45874  1.000 42.22750  ? 180 VAL H N   1 
ATOM   1345 C CA  . VAL A 1 184 ? -25.70807 -6.44081  30.88747  1.000 37.65968  ? 180 VAL H CA  1 
ATOM   1346 C C   . VAL A 1 184 ? -26.51055 -5.97664  29.68309  1.000 45.75254  ? 180 VAL H C   1 
ATOM   1347 O O   . VAL A 1 184 ? -26.05779 -6.03301  28.53661  1.000 45.20304  ? 180 VAL H O   1 
ATOM   1348 C CB  . VAL A 1 184 ? -25.05350 -5.23154  31.58865  1.000 39.62737  ? 180 VAL H CB  1 
ATOM   1349 C CG1 . VAL A 1 184 ? -24.27281 -5.68624  32.80519  1.000 35.80999  ? 180 VAL H CG1 1 
ATOM   1350 C CG2 . VAL A 1 184 ? -24.16087 -4.47016  30.61915  1.000 37.94338  ? 180 VAL H CG2 1 
ATOM   1351 N N   . VAL A 1 185 ? -27.72473 -5.51586  29.96274  1.000 46.74086  ? 181 VAL H N   1 
ATOM   1352 C CA  . VAL A 1 185 ? -28.59497 -4.95957  28.93295  1.000 43.66125  ? 181 VAL H CA  1 
ATOM   1353 C C   . VAL A 1 185 ? -29.38904 -3.81766  29.55333  1.000 39.30537  ? 181 VAL H C   1 
ATOM   1354 O O   . VAL A 1 185 ? -29.75731 -3.86235  30.73157  1.000 39.59649  ? 181 VAL H O   1 
ATOM   1355 C CB  . VAL A 1 185 ? -29.51390 -6.04086  28.31309  1.000 37.63046  ? 181 VAL H CB  1 
ATOM   1356 C CG1 . VAL A 1 185 ? -30.42636 -6.65795  29.37140  1.000 41.35983  ? 181 VAL H CG1 1 
ATOM   1357 C CG2 . VAL A 1 185 ? -30.32235 -5.47142  27.15364  1.000 49.94626  ? 181 VAL H CG2 1 
ATOM   1358 N N   . THR A 1 186 ? -29.60560 -2.77225  28.76577  1.000 43.27291  ? 182 THR H N   1 
ATOM   1359 C CA  . THR A 1 186 ? -30.44579 -1.65113  29.15209  1.000 43.35440  ? 182 THR H CA  1 
ATOM   1360 C C   . THR A 1 186 ? -31.78888 -1.76906  28.43701  1.000 53.03018  ? 182 THR H C   1 
ATOM   1361 O O   . THR A 1 186 ? -31.83412 -1.95843  27.21660  1.000 56.61096  ? 182 THR H O   1 
ATOM   1362 C CB  . THR A 1 186 ? -29.75788 -0.32209  28.83415  1.000 48.11188  ? 182 THR H CB  1 
ATOM   1363 O OG1 . THR A 1 186 ? -29.13024 -0.38973  27.54443  1.000 55.96794  ? 182 THR H OG1 1 
ATOM   1364 C CG2 . THR A 1 186 ? -28.69943 -0.02997  29.88149  1.000 46.46741  ? 182 THR H CG2 1 
ATOM   1365 N N   . VAL A 1 187 ? -32.87021 -1.69887  29.20998  1.000 46.62656  ? 183 VAL H N   1 
ATOM   1366 C CA  . VAL A 1 187 ? -34.23351 -1.87786  28.71463  1.000 47.45939  ? 183 VAL H CA  1 
ATOM   1367 C C   . VAL A 1 187 ? -35.09925 -0.76981  29.29890  1.000 61.28234  ? 183 VAL H C   1 
ATOM   1368 O O   . VAL A 1 187 ? -34.75284 -0.17751  30.33392  1.000 62.06568  ? 183 VAL H O   1 
ATOM   1369 C CB  . VAL A 1 187 ? -34.80381 -3.26539  29.09451  1.000 44.38027  ? 183 VAL H CB  1 
ATOM   1370 C CG1 . VAL A 1 187 ? -33.93142 -4.38496  28.56344  1.000 44.05408  ? 183 VAL H CG1 1 
ATOM   1371 C CG2 . VAL A 1 187 ? -34.99150 -3.37547  30.60365  1.000 31.36389  ? 183 VAL H CG2 1 
ATOM   1372 N N   . PRO A 1 188 ? -36.23371 -0.46011  28.66014  1.000 64.86289  ? 184 PRO H N   1 
ATOM   1373 C CA  . PRO A 1 188 ? -37.14558 0.53975   29.23428  1.000 56.85608  ? 184 PRO H CA  1 
ATOM   1374 C C   . PRO A 1 188 ? -37.70316 0.07944   30.57312  1.000 61.58753  ? 184 PRO H C   1 
ATOM   1375 O O   . PRO A 1 188 ? -38.01674 -1.09750  30.76453  1.000 63.70953  ? 184 PRO H O   1 
ATOM   1376 C CB  . PRO A 1 188 ? -38.24835 0.67066   28.17558  1.000 61.05291  ? 184 PRO H CB  1 
ATOM   1377 C CG  . PRO A 1 188 ? -38.13894 -0.55935  27.34065  1.000 69.18991  ? 184 PRO H CG  1 
ATOM   1378 C CD  . PRO A 1 188 ? -36.68323 -0.90366  27.33020  1.000 58.67000  ? 184 PRO H CD  1 
ATOM   1379 N N   . SER A 1 189 ? -37.83041 1.03246   31.50452  1.000 61.75904  ? 185 SER H N   1 
ATOM   1380 C CA  . SER A 1 189 ? -38.23646 0.69844   32.86706  1.000 57.77130  ? 185 SER H CA  1 
ATOM   1381 C C   . SER A 1 189 ? -39.66190 0.16121   32.92998  1.000 59.60531  ? 185 SER H C   1 
ATOM   1382 O O   . SER A 1 189 ? -39.98214 -0.63724  33.81941  1.000 53.37327  ? 185 SER H O   1 
ATOM   1383 C CB  . SER A 1 189 ? -38.09763 1.92471   33.76887  1.000 74.42448  ? 185 SER H CB  1 
ATOM   1384 O OG  . SER A 1 189 ? -36.78088 2.44731   33.72654  1.000 74.30761  ? 185 SER H OG  1 
ATOM   1385 N N   . SER A 1 190 ? -40.52663 0.57862   32.00187  1.000 56.32292  ? 186 SER H N   1 
ATOM   1386 C CA  . SER A 1 190 ? -41.93136 0.18275   32.04417  1.000 61.25488  ? 186 SER H CA  1 
ATOM   1387 C C   . SER A 1 190 ? -42.13631 -1.29970  31.76665  1.000 65.76930  ? 186 SER H C   1 
ATOM   1388 O O   . SER A 1 190 ? -43.19421 -1.84261  32.10650  1.000 64.23314  ? 186 SER H O   1 
ATOM   1389 C CB  . SER A 1 190 ? -42.72868 1.00005   31.03228  1.000 54.35541  ? 186 SER H CB  1 
ATOM   1390 O OG  . SER A 1 190 ? -42.28684 0.71985   29.71692  1.000 65.95042  ? 186 SER H OG  1 
ATOM   1391 N N   . SER A 1 191 ? -41.15968 -1.95868  31.15141  1.000 67.13043  ? 187 SER H N   1 
ATOM   1392 C CA  . SER A 1 191 ? -41.25929 -3.36575  30.79506  1.000 55.84115  ? 187 SER H CA  1 
ATOM   1393 C C   . SER A 1 191 ? -40.90023 -4.30202  31.93922  1.000 56.31983  ? 187 SER H C   1 
ATOM   1394 O O   . SER A 1 191 ? -41.08306 -5.51487  31.80413  1.000 64.58457  ? 187 SER H O   1 
ATOM   1395 C CB  . SER A 1 191 ? -40.35151 -3.66277  29.60393  1.000 56.24332  ? 187 SER H CB  1 
ATOM   1396 O OG  . SER A 1 191 ? -38.99654 -3.43049  29.95148  1.000 61.02193  ? 187 SER H OG  1 
ATOM   1397 N N   . LEU A 1 192 ? -40.40504 -3.77615  33.06008  1.000 58.81141  ? 188 LEU H N   1 
ATOM   1398 C CA  . LEU A 1 192 ? -39.88923 -4.62452  34.12705  1.000 54.01464  ? 188 LEU H CA  1 
ATOM   1399 C C   . LEU A 1 192 ? -40.96408 -5.46750  34.80787  1.000 60.73333  ? 188 LEU H C   1 
ATOM   1400 O O   . LEU A 1 192 ? -40.61835 -6.36720  35.58154  1.000 67.36015  ? 188 LEU H O   1 
ATOM   1401 C CB  . LEU A 1 192 ? -39.15765 -3.76672  35.16903  1.000 62.25229  ? 188 LEU H CB  1 
ATOM   1402 C CG  . LEU A 1 192 ? -37.87934 -3.00998  34.76483  1.000 59.59946  ? 188 LEU H CG  1 
ATOM   1403 C CD1 . LEU A 1 192 ? -37.20515 -2.35486  35.97439  1.000 63.77196  ? 188 LEU H CD1 1 
ATOM   1404 C CD2 . LEU A 1 192 ? -36.89845 -3.91315  34.03892  1.000 44.18327  ? 188 LEU H CD2 1 
ATOM   1405 N N   . GLY A 1 193 ? -42.24432 -5.20782  34.55398  1.000 74.11583  ? 189 GLY H N   1 
ATOM   1406 C CA  . GLY A 1 193 ? -43.30027 -6.02228  35.13152  1.000 70.57660  ? 189 GLY H CA  1 
ATOM   1407 C C   . GLY A 1 193 ? -43.99679 -6.84463  34.07107  1.000 65.13823  ? 189 GLY H C   1 
ATOM   1408 O O   . GLY A 1 193 ? -44.74842 -7.77747  34.36867  1.000 71.70862  ? 189 GLY H O   1 
ATOM   1409 N N   . THR A 1 194 ? -43.73180 -6.48796  32.81688  1.000 65.90910  ? 190 THR H N   1 
ATOM   1410 C CA  . THR A 1 194 ? -44.30906 -7.11035  31.63467  1.000 69.38278  ? 190 THR H CA  1 
ATOM   1411 C C   . THR A 1 194 ? -43.35566 -8.09750  30.97100  1.000 71.12162  ? 190 THR H C   1 
ATOM   1412 O O   . THR A 1 194 ? -43.71731 -9.25335  30.73267  1.000 69.34334  ? 190 THR H O   1 
ATOM   1413 C CB  . THR A 1 194 ? -44.70753 -6.01999  30.63137  1.000 68.21190  ? 190 THR H CB  1 
ATOM   1414 O OG1 . THR A 1 194 ? -45.86298 -5.32337  31.11357  1.000 79.45364  ? 190 THR H OG1 1 
ATOM   1415 C CG2 . THR A 1 194 ? -44.98934 -6.61279  29.25709  1.000 71.64045  ? 190 THR H CG2 1 
ATOM   1416 N N   . GLN A 1 195 ? -42.13496 -7.66468  30.67551  1.000 61.52049  ? 191 GLN H N   1 
ATOM   1417 C CA  . GLN A 1 195 ? -41.19533 -8.46641  29.90821  1.000 62.64599  ? 191 GLN H CA  1 
ATOM   1418 C C   . GLN A 1 195 ? -40.34566 -9.32374  30.83643  1.000 54.76463  ? 191 GLN H C   1 
ATOM   1419 O O   . GLN A 1 195 ? -39.78958 -8.82288  31.81735  1.000 54.19827  ? 191 GLN H O   1 
ATOM   1420 C CB  . GLN A 1 195 ? -40.29444 -7.57197  29.06009  1.000 46.95982  ? 191 GLN H CB  1 
ATOM   1421 C CG  . GLN A 1 195 ? -39.45378 -8.35800  28.09356  1.000 56.85551  ? 191 GLN H CG  1 
ATOM   1422 C CD  . GLN A 1 195 ? -40.30345 -9.11680  27.09670  1.000 65.15252  ? 191 GLN H CD  1 
ATOM   1423 O OE1 . GLN A 1 195 ? -40.18984 -10.33575 26.97120  1.000 64.51708  ? 191 GLN H OE1 1 
ATOM   1424 N NE2 . GLN A 1 195 ? -41.16607 -8.39677  26.38176  1.000 61.95816  ? 191 GLN H NE2 1 
ATOM   1425 N N   . THR A 1 196 ? -40.24570 -10.61273 30.52305  1.000 55.46637  ? 192 THR H N   1 
ATOM   1426 C CA  . THR A 1 196 ? -39.35748 -11.51757 31.24024  1.000 55.84711  ? 192 THR H CA  1 
ATOM   1427 C C   . THR A 1 196 ? -37.97638 -11.49500 30.58938  1.000 53.77052  ? 192 THR H C   1 
ATOM   1428 O O   . THR A 1 196 ? -37.86809 -11.47331 29.35999  1.000 57.24421  ? 192 THR H O   1 
ATOM   1429 C CB  . THR A 1 196 ? -39.94299 -12.92763 31.25401  1.000 52.88694  ? 192 THR H CB  1 
ATOM   1430 O OG1 . THR A 1 196 ? -40.97200 -12.99221 32.25023  1.000 67.09197  ? 192 THR H OG1 1 
ATOM   1431 C CG2 . THR A 1 196 ? -38.88151 -13.95836 31.57278  1.000 47.60138  ? 192 THR H CG2 1 
ATOM   1432 N N   . TYR A 1 197 ? -36.92433 -11.45209 31.41285  1.000 57.01713  ? 193 TYR H N   1 
ATOM   1433 C CA  . TYR A 1 197 ? -35.54460 -11.38525 30.93344  1.000 51.31855  ? 193 TYR H CA  1 
ATOM   1434 C C   . TYR A 1 197 ? -34.74161 -12.55576 31.48640  1.000 49.93261  ? 193 TYR H C   1 
ATOM   1435 O O   . TYR A 1 197 ? -34.62610 -12.71688 32.70713  1.000 45.97221  ? 193 TYR H O   1 
ATOM   1436 C CB  . TYR A 1 197 ? -34.89062 -10.06263 31.32132  1.000 41.92606  ? 193 TYR H CB  1 
ATOM   1437 C CG  . TYR A 1 197 ? -35.55054 -8.87187  30.69872  1.000 48.72742  ? 193 TYR H CG  1 
ATOM   1438 C CD1 . TYR A 1 197 ? -35.25825 -8.49637  29.39128  1.000 46.97188  ? 193 TYR H CD1 1 
ATOM   1439 C CD2 . TYR A 1 197 ? -36.46274 -8.11486  31.41574  1.000 38.55678  ? 193 TYR H CD2 1 
ATOM   1440 C CE1 . TYR A 1 197 ? -35.86105 -7.39670  28.81356  1.000 43.72722  ? 193 TYR H CE1 1 
ATOM   1441 C CE2 . TYR A 1 197 ? -37.07006 -7.01467  30.85276  1.000 48.39074  ? 193 TYR H CE2 1 
ATOM   1442 C CZ  . TYR A 1 197 ? -36.77324 -6.65685  29.55083  1.000 51.65765  ? 193 TYR H CZ  1 
ATOM   1443 O OH  . TYR A 1 197 ? -37.39339 -5.55316  28.99392  1.000 50.26590  ? 193 TYR H OH  1 
ATOM   1444 N N   . ILE A 1 198 ? -34.18379 -13.36176 30.58341  1.000 51.95750  ? 194 ILE H N   1 
ATOM   1445 C CA  . ILE A 1 198 ? -33.42331 -14.55696 30.92710  1.000 46.48847  ? 194 ILE H CA  1 
ATOM   1446 C C   . ILE A 1 198 ? -32.09186 -14.51019 30.19602  1.000 47.57366  ? 194 ILE H C   1 
ATOM   1447 O O   . ILE A 1 198 ? -32.06021 -14.34563 28.97005  1.000 45.25986  ? 194 ILE H O   1 
ATOM   1448 C CB  . ILE A 1 198 ? -34.18611 -15.83847 30.54848  1.000 52.11194  ? 194 ILE H CB  1 
ATOM   1449 C CG1 . ILE A 1 198 ? -35.49834 -15.92205 31.33153  1.000 55.36408  ? 194 ILE H CG1 1 
ATOM   1450 C CG2 . ILE A 1 198 ? -33.30604 -17.06565 30.76615  1.000 47.23196  ? 194 ILE H CG2 1 
ATOM   1451 C CD1 . ILE A 1 198 ? -36.31319 -17.14573 31.02662  1.000 45.71862  ? 194 ILE H CD1 1 
ATOM   1452 N N   . CYS A 1 199 ? -30.99482 -14.65465 30.93326  1.000 39.32010  ? 195 CYS H N   1 
ATOM   1453 C CA  . CYS A 1 199 ? -29.69793 -14.80427 30.28334  1.000 51.13589  ? 195 CYS H CA  1 
ATOM   1454 C C   . CYS A 1 199 ? -29.36338 -16.27953 30.11929  1.000 51.62961  ? 195 CYS H C   1 
ATOM   1455 O O   . CYS A 1 199 ? -29.61802 -17.09571 31.01198  1.000 47.27223  ? 195 CYS H O   1 
ATOM   1456 C CB  . CYS A 1 199 ? -28.59602 -14.10220 31.06532  1.000 39.10708  ? 195 CYS H CB  1 
ATOM   1457 S SG  . CYS A 1 199 ? -28.27874 -14.88597 32.63173  1.000 49.26232  ? 195 CYS H SG  1 
ATOM   1458 N N   . ASN A 1 200 ? -28.79915 -16.60914 28.96523  1.000 42.87708  ? 196 ASN H N   1 
ATOM   1459 C CA  . ASN A 1 200 ? -28.41907 -17.97041 28.61553  1.000 40.58903  ? 196 ASN H CA  1 
ATOM   1460 C C   . ASN A 1 200 ? -26.89562 -18.00943 28.55630  1.000 47.46552  ? 196 ASN H C   1 
ATOM   1461 O O   . ASN A 1 200 ? -26.28593 -17.47612 27.62314  1.000 44.61856  ? 196 ASN H O   1 
ATOM   1462 C CB  . ASN A 1 200 ? -29.05821 -18.37245 27.29705  1.000 40.98603  ? 196 ASN H CB  1 
ATOM   1463 C CG  . ASN A 1 200 ? -30.40605 -17.71473 27.09078  1.000 46.77800  ? 196 ASN H CG  1 
ATOM   1464 O OD1 . ASN A 1 200 ? -30.54018 -16.78853 26.29304  1.000 41.00909  ? 196 ASN H OD1 1 
ATOM   1465 N ND2 . ASN A 1 200 ? -31.40834 -18.18359 27.81832  1.000 44.31130  ? 196 ASN H ND2 1 
ATOM   1466 N N   . VAL A 1 201 ? -26.29180 -18.61997 29.57215  1.000 38.88547  ? 197 VAL H N   1 
ATOM   1467 C CA  . VAL A 1 201 ? -24.84535 -18.75193 29.68416  1.000 48.59491  ? 197 VAL H CA  1 
ATOM   1468 C C   . VAL A 1 201 ? -24.48011 -20.18609 29.33023  1.000 47.54200  ? 197 VAL H C   1 
ATOM   1469 O O   . VAL A 1 201 ? -24.91652 -21.12927 30.00216  1.000 45.48480  ? 197 VAL H O   1 
ATOM   1470 C CB  . VAL A 1 201 ? -24.35963 -18.38836 31.09521  1.000 40.85926  ? 197 VAL H CB  1 
ATOM   1471 C CG1 . VAL A 1 201 ? -22.85467 -18.21915 31.11202  1.000 39.49263  ? 197 VAL H CG1 1 
ATOM   1472 C CG2 . VAL A 1 201 ? -25.05642 -17.12939 31.57992  1.000 41.23421  ? 197 VAL H CG2 1 
ATOM   1473 N N   . ASN A 1 202 ? -23.71175 -20.35676 28.25765  1.000 47.69478  ? 198 ASN H N   1 
ATOM   1474 C CA  . ASN A 1 202 ? -23.22853 -21.66295 27.83760  1.000 47.03250  ? 198 ASN H CA  1 
ATOM   1475 C C   . ASN A 1 202 ? -21.73647 -21.73217 28.11579  1.000 48.89475  ? 198 ASN H C   1 
ATOM   1476 O O   . ASN A 1 202 ? -21.00888 -20.76061 27.87944  1.000 48.78983  ? 198 ASN H O   1 
ATOM   1477 C CB  . ASN A 1 202 ? -23.52397 -21.91600 26.35869  1.000 49.21375  ? 198 ASN H CB  1 
ATOM   1478 C CG  . ASN A 1 202 ? -23.29818 -23.36828 25.94679  1.000 56.67058  ? 198 ASN H CG  1 
ATOM   1479 O OD1 . ASN A 1 202 ? -23.12829 -24.26030 26.78109  1.000 58.15970  ? 198 ASN H OD1 1 
ATOM   1480 N ND2 . ASN A 1 202 ? -23.29665 -23.60588 24.64536  1.000 73.32889  ? 198 ASN H ND2 1 
ATOM   1481 N N   . HIS A 1 203 ? -21.29418 -22.86390 28.65669  1.000 48.16517  ? 199 HIS H N   1 
ATOM   1482 C CA  . HIS A 1 203 ? -19.89023 -23.08841 28.99084  1.000 40.50144  ? 199 HIS H CA  1 
ATOM   1483 C C   . HIS A 1 203 ? -19.51593 -24.43328 28.38932  1.000 44.18023  ? 199 HIS H C   1 
ATOM   1484 O O   . HIS A 1 203 ? -19.48931 -25.45130 29.08544  1.000 47.43881  ? 199 HIS H O   1 
ATOM   1485 C CB  . HIS A 1 203 ? -19.66598 -23.05582 30.47873  1.000 44.55801  ? 199 HIS H CB  1 
ATOM   1486 C CG  . HIS A 1 203 ? -18.22785 -23.19054 30.86729  1.000 47.79906  ? 199 HIS H CG  1 
ATOM   1487 N ND1 . HIS A 1 203 ? -17.77091 -24.18480 31.70521  1.000 47.01143  ? 199 HIS H ND1 1 
ATOM   1488 C CD2 . HIS A 1 203 ? -17.14127 -22.45610 30.52732  1.000 46.82534  ? 199 HIS H CD2 1 
ATOM   1489 C CE1 . HIS A 1 203 ? -16.46577 -24.05422 31.86859  1.000 47.46278  ? 199 HIS H CE1 1 
ATOM   1490 N NE2 . HIS A 1 203 ? -16.05967 -23.01042 31.16778  1.000 47.05501  ? 199 HIS H NE2 1 
ATOM   1491 N N   . LYS A 1 204 ? -19.23900 -24.42537 27.08686  1.000 48.72688  ? 200 LYS H N   1 
ATOM   1492 C CA  . LYS A 1 204 ? -18.94884 -25.66771 26.37800  1.000 52.57374  ? 200 LYS H CA  1 
ATOM   1493 C C   . LYS A 1 204 ? -17.86888 -26.52311 27.03436  1.000 45.24082  ? 200 LYS H C   1 
ATOM   1494 O O   . LYS A 1 204 ? -18.05833 -27.75024 27.09492  1.000 50.64534  ? 200 LYS H O   1 
ATOM   1495 C CB  . LYS A 1 204 ? -18.57848 -25.34972 24.92623  1.000 52.94561  ? 200 LYS H CB  1 
ATOM   1496 C CG  . LYS A 1 204 ? -18.42644 -26.57784 24.05037  1.000 62.27693  ? 200 LYS H CG  1 
ATOM   1497 C CD  . LYS A 1 204 ? -17.91814 -26.20685 22.66380  1.000 58.84361  ? 200 LYS H CD  1 
ATOM   1498 C CE  . LYS A 1 204 ? -17.78206 -27.44204 21.78399  1.000 69.46606  ? 200 LYS H CE  1 
ATOM   1499 N NZ  . LYS A 1 204 ? -17.61984 -27.10654 20.34200  1.000 91.27490  ? 200 LYS H NZ  1 
ATOM   1500 N N   . PRO A 1 205 ? -16.75045 -25.98133 27.53735  1.000 45.76730  ? 201 PRO H N   1 
ATOM   1501 C CA  . PRO A 1 205 ? -15.73937 -26.86108 28.15347  1.000 48.65961  ? 201 PRO H CA  1 
ATOM   1502 C C   . PRO A 1 205 ? -16.28869 -27.79217 29.22305  1.000 55.81664  ? 201 PRO H C   1 
ATOM   1503 O O   . PRO A 1 205 ? -15.80601 -28.92448 29.35159  1.000 61.54548  ? 201 PRO H O   1 
ATOM   1504 C CB  . PRO A 1 205 ? -14.73184 -25.86669 28.74605  1.000 42.86615  ? 201 PRO H CB  1 
ATOM   1505 C CG  . PRO A 1 205 ? -14.82953 -24.68652 27.87895  1.000 49.92503  ? 201 PRO H CG  1 
ATOM   1506 C CD  . PRO A 1 205 ? -16.27994 -24.58131 27.48970  1.000 46.95620  ? 201 PRO H CD  1 
ATOM   1507 N N   . SER A 1 206 ? -17.28420 -27.35916 29.99443  1.000 54.80571  ? 202 SER H N   1 
ATOM   1508 C CA  . SER A 1 206 ? -17.86050 -28.19261 31.04101  1.000 55.71586  ? 202 SER H CA  1 
ATOM   1509 C C   . SER A 1 206 ? -19.25711 -28.67499 30.69672  1.000 42.86208  ? 202 SER H C   1 
ATOM   1510 O O   . SER A 1 206 ? -19.93446 -29.22266 31.56956  1.000 48.42195  ? 202 SER H O   1 
ATOM   1511 C CB  . SER A 1 206 ? -17.89410 -27.44531 32.37480  1.000 47.17591  ? 202 SER H CB  1 
ATOM   1512 O OG  . SER A 1 206 ? -19.01604 -26.59541 32.44343  1.000 41.78412  ? 202 SER H OG  1 
ATOM   1513 N N   . ASN A 1 207 ? -19.70550 -28.46774 29.45693  1.000 43.60388  ? 203 ASN H N   1 
ATOM   1514 C CA  . ASN A 1 207 ? -21.01043 -28.94863 28.98930  1.000 46.59689  ? 203 ASN H CA  1 
ATOM   1515 C C   . ASN A 1 207 ? -22.13604 -28.45829 29.88733  1.000 44.09067  ? 203 ASN H C   1 
ATOM   1516 O O   . ASN A 1 207 ? -23.13774 -29.14101 30.11827  1.000 41.31608  ? 203 ASN H O   1 
ATOM   1517 C CB  . ASN A 1 207 ? -21.01720 -30.46156 28.88247  1.000 51.62689  ? 203 ASN H CB  1 
ATOM   1518 C CG  . ASN A 1 207 ? -20.06887 -30.95703 27.82923  1.000 61.64854  ? 203 ASN H CG  1 
ATOM   1519 O OD1 . ASN A 1 207 ? -20.30824 -30.78851 26.63224  1.000 69.58085  ? 203 ASN H OD1 1 
ATOM   1520 N ND2 . ASN A 1 207 ? -18.98149 -31.57972 28.26423  1.000 57.19368  ? 203 ASN H ND2 1 
ATOM   1521 N N   . THR A 1 208 ? -21.95956 -27.25236 30.39530  1.000 47.88238  ? 204 THR H N   1 
ATOM   1522 C CA  . THR A 1 208 ? -22.92882 -26.61511 31.26213  1.000 45.71446  ? 204 THR H CA  1 
ATOM   1523 C C   . THR A 1 208 ? -23.56814 -25.46806 30.50053  1.000 48.78431  ? 204 THR H C   1 
ATOM   1524 O O   . THR A 1 208 ? -22.86728 -24.67326 29.85721  1.000 47.30152  ? 204 THR H O   1 
ATOM   1525 C CB  . THR A 1 208 ? -22.27298 -26.10500 32.54962  1.000 44.78053  ? 204 THR H CB  1 
ATOM   1526 O OG1 . THR A 1 208 ? -21.56236 -27.17853 33.18126  1.000 54.33385  ? 204 THR H OG1 1 
ATOM   1527 C CG2 . THR A 1 208 ? -23.32218 -25.57254 33.51563  1.000 42.33451  ? 204 THR H CG2 1 
ATOM   1528 N N   . LYS A 1 209 ? -24.89540 -25.41465 30.54533  1.000 44.37301  ? 205 LYS H N   1 
ATOM   1529 C CA  . LYS A 1 209 ? -25.66001 -24.23333 30.17820  1.000 44.83283  ? 205 LYS H CA  1 
ATOM   1530 C C   . LYS A 1 209 ? -26.49025 -23.83172 31.38730  1.000 41.60520  ? 205 LYS H C   1 
ATOM   1531 O O   . LYS A 1 209 ? -27.18195 -24.67197 31.96957  1.000 40.69067  ? 205 LYS H O   1 
ATOM   1532 C CB  . LYS A 1 209 ? -26.56144 -24.49643 28.97217  1.000 48.12886  ? 205 LYS H CB  1 
ATOM   1533 C CG  . LYS A 1 209 ? -27.16121 -23.22839 28.39459  1.000 59.04610  ? 205 LYS H CG  1 
ATOM   1534 C CD  . LYS A 1 209 ? -28.27058 -23.52886 27.41563  1.000 45.35231  ? 205 LYS H CD  1 
ATOM   1535 C CE  . LYS A 1 209 ? -29.46640 -24.13191 28.11545  1.000 50.40237  ? 205 LYS H CE  1 
ATOM   1536 N NZ  . LYS A 1 209 ? -30.65703 -24.15963 27.21259  1.000 56.63694  ? 205 LYS H NZ  1 
ATOM   1537 N N   . VAL A 1 210 ? -26.39654 -22.56640 31.78563  1.000 46.01756  ? 206 VAL H N   1 
ATOM   1538 C CA  . VAL A 1 210 ? -27.20901 -22.02325 32.86818  1.000 48.74123  ? 206 VAL H CA  1 
ATOM   1539 C C   . VAL A 1 210 ? -28.09348 -20.92223 32.29511  1.000 54.18899  ? 206 VAL H C   1 
ATOM   1540 O O   . VAL A 1 210 ? -27.59197 -19.96598 31.69063  1.000 48.66059  ? 206 VAL H O   1 
ATOM   1541 C CB  . VAL A 1 210 ? -26.35764 -21.48279 34.02720  1.000 48.09870  ? 206 VAL H CB  1 
ATOM   1542 C CG1 . VAL A 1 210 ? -27.25749 -21.10762 35.20723  1.000 35.75578  ? 206 VAL H CG1 1 
ATOM   1543 C CG2 . VAL A 1 210 ? -25.30655 -22.49419 34.44726  1.000 41.88771  ? 206 VAL H CG2 1 
ATOM   1544 N N   . ASP A 1 211 ? -29.40443 -21.06537 32.47654  1.000 56.07523  ? 207 ASP H N   1 
ATOM   1545 C CA  . ASP A 1 211 ? -30.36904 -20.00845 32.20052  1.000 48.71550  ? 207 ASP H CA  1 
ATOM   1546 C C   . ASP A 1 211 ? -30.80037 -19.39127 33.52620  1.000 52.09177  ? 207 ASP H C   1 
ATOM   1547 O O   . ASP A 1 211 ? -31.09107 -20.11578 34.48514  1.000 51.28483  ? 207 ASP H O   1 
ATOM   1548 C CB  . ASP A 1 211 ? -31.58670 -20.55162 31.44919  1.000 49.38296  ? 207 ASP H CB  1 
ATOM   1549 C CG  . ASP A 1 211 ? -31.22545 -21.18488 30.11400  1.000 50.41075  ? 207 ASP H CG  1 
ATOM   1550 O OD1 . ASP A 1 211 ? -30.60138 -20.50765 29.26893  1.000 50.91359  ? 207 ASP H OD1 1 
ATOM   1551 O OD2 . ASP A 1 211 ? -31.56714 -22.37023 29.91599  1.000 52.03298  ? 207 ASP H OD2 1 
ATOM   1552 N N   . LYS A 1 212 ? -30.83556 -18.05864 33.58135  1.000 47.97187  ? 208 LYS H N   1 
ATOM   1553 C CA  . LYS A 1 212 ? -31.17289 -17.32944 34.79908  1.000 47.14466  ? 208 LYS H CA  1 
ATOM   1554 C C   . LYS A 1 212 ? -32.21398 -16.26317 34.49003  1.000 45.55601  ? 208 LYS H C   1 
ATOM   1555 O O   . LYS A 1 212 ? -32.01886 -15.45168 33.58329  1.000 41.33825  ? 208 LYS H O   1 
ATOM   1556 C CB  . LYS A 1 212 ? -29.93096 -16.67262 35.41299  1.000 46.61096  ? 208 LYS H CB  1 
ATOM   1557 C CG  . LYS A 1 212 ? -30.09471 -16.23739 36.85590  1.000 46.39695  ? 208 LYS H CG  1 
ATOM   1558 C CD  . LYS A 1 212 ? -30.03773 -17.44142 37.76723  1.000 57.76561  ? 208 LYS H CD  1 
ATOM   1559 C CE  . LYS A 1 212 ? -29.73159 -17.04372 39.19309  1.000 59.56160  ? 208 LYS H CE  1 
ATOM   1560 N NZ  . LYS A 1 212 ? -29.41777 -18.24296 40.01161  1.000 53.74164  ? 208 LYS H NZ  1 
ATOM   1561 N N   . LYS A 1 213 ? -33.30949 -16.26011 35.24830  1.000 54.87996  ? 209 LYS H N   1 
ATOM   1562 C CA  . LYS A 1 213 ? -34.32514 -15.21594 35.15617  1.000 50.14964  ? 209 LYS H CA  1 
ATOM   1563 C C   . LYS A 1 213 ? -33.92626 -14.05139 36.06005  1.000 43.98741  ? 209 LYS H C   1 
ATOM   1564 O O   . LYS A 1 213 ? -33.65180 -14.25019 37.24602  1.000 45.58496  ? 209 LYS H O   1 
ATOM   1565 C CB  . LYS A 1 213 ? -35.69365 -15.76733 35.54910  1.000 58.48498  ? 209 LYS H CB  1 
ATOM   1566 C CG  . LYS A 1 213 ? -36.84573 -14.77224 35.44425  1.000 65.36446  ? 209 LYS H CG  1 
ATOM   1567 C CD  . LYS A 1 213 ? -38.08991 -15.45220 34.88075  1.000 54.75279  ? 209 LYS H CD  1 
ATOM   1568 C CE  . LYS A 1 213 ? -39.31073 -15.26601 35.76558  1.000 61.30626  ? 209 LYS H CE  1 
ATOM   1569 N NZ  . LYS A 1 213 ? -39.79479 -13.86004 35.75600  1.000 64.48719  ? 209 LYS H NZ  1 
ATOM   1570 N N   . VAL A 1 214 ? -33.88173 -12.84385 35.50546  1.000 42.94783  ? 210 VAL H N   1 
ATOM   1571 C CA  . VAL A 1 214 ? -33.45006 -11.66025 36.24251  1.000 53.58279  ? 210 VAL H CA  1 
ATOM   1572 C C   . VAL A 1 214 ? -34.69526 -10.82244 36.51672  1.000 57.46385  ? 210 VAL H C   1 
ATOM   1573 O O   . VAL A 1 214 ? -35.15814 -10.06247 35.65812  1.000 55.89909  ? 210 VAL H O   1 
ATOM   1574 C CB  . VAL A 1 214 ? -32.37615 -10.87549 35.48241  1.000 43.53177  ? 210 VAL H CB  1 
ATOM   1575 C CG1 . VAL A 1 214 ? -31.85088 -9.73074  36.33051  1.000 44.36128  ? 210 VAL H CG1 1 
ATOM   1576 C CG2 . VAL A 1 214 ? -31.23752 -11.79189 35.10879  1.000 38.41916  ? 210 VAL H CG2 1 
ATOM   1577 N N   . GLU A 1 215 ? -35.25077 -10.96802 37.74800  1.000 53.89251  ? 211 GLU H N   1 
ATOM   1578 C CA  . GLU A 1 215 ? -36.44555 -10.32354 38.26425  1.000 54.29202  ? 211 GLU H CA  1 
ATOM   1579 C C   . GLU A 1 215 ? -36.09138 -9.10116  39.10225  1.000 64.33491  ? 211 GLU H C   1 
ATOM   1580 O O   . GLU A 1 215 ? -35.03480 -9.05759  39.74132  1.000 66.07297  ? 211 GLU H O   1 
ATOM   1581 C CB  . GLU A 1 215 ? -37.25615 -11.29939 39.11459  1.000 53.09760  ? 211 GLU H CB  1 
ATOM   1582 C CG  . GLU A 1 215 ? -37.96513 -12.34797 38.30137  1.000 59.94825  ? 211 GLU H CG  1 
ATOM   1583 C CD  . GLU A 1 215 ? -38.64024 -13.37771 39.16560  1.000 61.91704  ? 211 GLU H CD  1 
ATOM   1584 O OE1 . GLU A 1 215 ? -38.14289 -13.61867 40.28466  1.000 59.46316  ? 211 GLU H OE1 1 
ATOM   1585 O OE2 . GLU A 1 215 ? -39.66312 -13.94598 38.72768  1.000 67.26733  ? 211 GLU H OE2 1 
ATOM   1586 N N   . PRO A 1 216 ? -36.95620 -8.08919  39.10633  1.000 61.62399  ? 212 PRO H N   1 
ATOM   1587 C CA  . PRO A 1 216 ? -36.71046 -6.91522  39.94859  1.000 62.97460  ? 212 PRO H CA  1 
ATOM   1588 C C   . PRO A 1 216 ? -36.71962 -7.27679  41.42784  1.000 60.97253  ? 212 PRO H C   1 
ATOM   1589 O O   . PRO A 1 216 ? -37.22940 -8.32231  41.83858  1.000 66.17746  ? 212 PRO H O   1 
ATOM   1590 C CB  . PRO A 1 216 ? -37.86693 -5.97713  39.58823  1.000 49.01008  ? 212 PRO H CB  1 
ATOM   1591 C CG  . PRO A 1 216 ? -38.25741 -6.39974  38.20444  1.000 43.09437  ? 212 PRO H CG  1 
ATOM   1592 C CD  . PRO A 1 216 ? -38.09865 -7.88595  38.20237  1.000 45.45232  ? 212 PRO H CD  1 
ATOM   1593 N N   . LYS A 1 217 ? -36.12317 -6.39346  42.22626  1.000 65.56131  ? 213 LYS H N   1 
ATOM   1594 C CA  . LYS A 1 217 ? -36.01954 -6.56532  43.67581  1.000 73.64992  ? 213 LYS H CA  1 
ATOM   1595 C C   . LYS A 1 217 ? -35.20272 -7.80332  44.03404  1.000 80.20806  ? 213 LYS H C   1 
ATOM   1596 O O   . LYS A 1 217 ? -34.35568 -7.76154  44.93313  1.000 79.87134  ? 213 LYS H O   1 
ATOM   1597 C CB  . LYS A 1 217 ? -37.40891 -6.64190  44.33250  1.000 48.59464  ? 213 LYS H CB  1 
ATOM   1598 C CG  . LYS A 1 217 ? -37.34151 -6.85383  45.84152  1.000 71.74311  ? 213 LYS H CG  1 
ATOM   1599 C CD  . LYS A 1 217 ? -38.63263 -6.49766  46.54772  1.000 59.02328  ? 213 LYS H CD  1 
ATOM   1600 C CE  . LYS A 1 217 ? -38.38620 -6.29026  48.03273  1.000 66.98306  ? 213 LYS H CE  1 
ATOM   1601 N NZ  . LYS A 1 217 ? -39.61688 -5.84562  48.75285  1.000 76.48804  ? 213 LYS H NZ  1 
ATOM   1602 N N   . ASP B 2 1   ? 14.51457  -12.41372 17.72439  1.000 79.06474  ? 1   ASP L N   1 
ATOM   1603 C CA  . ASP B 2 1   ? 15.54950  -12.47989 16.70358  1.000 89.16598  ? 1   ASP L CA  1 
ATOM   1604 C C   . ASP B 2 1   ? 15.60157  -11.16826 15.91763  1.000 97.23199  ? 1   ASP L C   1 
ATOM   1605 O O   . ASP B 2 1   ? 16.64951  -10.77200 15.40724  1.000 110.93770 ? 1   ASP L O   1 
ATOM   1606 C CB  . ASP B 2 1   ? 15.29519  -13.67423 15.78493  1.000 85.92126  ? 1   ASP L CB  1 
ATOM   1607 C CG  . ASP B 2 1   ? 15.41468  -15.00213 16.51239  1.000 90.06961  ? 1   ASP L CG  1 
ATOM   1608 O OD1 . ASP B 2 1   ? 16.44862  -15.22085 17.17939  1.000 90.18353  ? 1   ASP L OD1 1 
ATOM   1609 O OD2 . ASP B 2 1   ? 14.47141  -15.82020 16.43061  1.000 86.17332  ? 1   ASP L OD2 1 
ATOM   1610 N N   . ILE B 2 2   ? 14.45210  -10.50457 15.83101  1.000 90.97629  ? 2   ILE L N   1 
ATOM   1611 C CA  . ILE B 2 2   ? 14.34588  -9.14437  15.31470  1.000 92.15376  ? 2   ILE L CA  1 
ATOM   1612 C C   . ILE B 2 2   ? 13.01733  -8.61101  15.82272  1.000 85.73336  ? 2   ILE L C   1 
ATOM   1613 O O   . ILE B 2 2   ? 12.19364  -9.37267  16.34115  1.000 86.98376  ? 2   ILE L O   1 
ATOM   1614 C CB  . ILE B 2 2   ? 14.43088  -9.08271  13.77848  1.000 90.98949  ? 2   ILE L CB  1 
ATOM   1615 C CG1 . ILE B 2 2   ? 14.96105  -7.71928  13.32470  1.000 87.63632  ? 2   ILE L CG1 1 
ATOM   1616 C CG2 . ILE B 2 2   ? 13.06295  -9.32639  13.16426  1.000 101.12675 ? 2   ILE L CG2 1 
ATOM   1617 C CD1 . ILE B 2 2   ? 14.93810  -7.52012  11.82069  1.000 92.45590  ? 2   ILE L CD1 1 
ATOM   1618 N N   . GLN B 2 3   ? 12.78914  -7.31083  15.68786  1.000 82.06350  ? 3   GLN L N   1 
ATOM   1619 C CA  . GLN B 2 3   ? 11.60626  -6.70404  16.28050  1.000 89.92673  ? 3   GLN L CA  1 
ATOM   1620 C C   . GLN B 2 3   ? 11.05057  -5.65824  15.33204  1.000 92.81579  ? 3   GLN L C   1 
ATOM   1621 O O   . GLN B 2 3   ? 11.77988  -4.76450  14.89265  1.000 100.43182 ? 3   GLN L O   1 
ATOM   1622 C CB  . GLN B 2 3   ? 11.94051  -6.08665  17.63956  1.000 99.75511  ? 3   GLN L CB  1 
ATOM   1623 C CG  . GLN B 2 3   ? 10.75265  -5.54309  18.40125  1.000 97.14155  ? 3   GLN L CG  1 
ATOM   1624 C CD  . GLN B 2 3   ? 11.05817  -5.37183  19.87553  1.000 96.40082  ? 3   GLN L CD  1 
ATOM   1625 O OE1 . GLN B 2 3   ? 12.00567  -5.96258  20.39700  1.000 78.58425  ? 3   GLN L OE1 1 
ATOM   1626 N NE2 . GLN B 2 3   ? 10.25904  -4.55799  20.55487  1.000 101.19795 ? 3   GLN L NE2 1 
ATOM   1627 N N   . MET B 2 4   ? 9.76600   -5.78294  15.01071  1.000 81.65287  ? 4   MET L N   1 
ATOM   1628 C CA  . MET B 2 4   ? 9.04134   -4.79343  14.21686  1.000 80.13028  ? 4   MET L CA  1 
ATOM   1629 C C   . MET B 2 4   ? 8.30832   -3.88185  15.19535  1.000 88.64575  ? 4   MET L C   1 
ATOM   1630 O O   . MET B 2 4   ? 7.19860   -4.17781  15.64385  1.000 92.85913  ? 4   MET L O   1 
ATOM   1631 C CB  . MET B 2 4   ? 8.08859   -5.47245  13.24093  1.000 80.38274  ? 4   MET L CB  1 
ATOM   1632 C CG  . MET B 2 4   ? 8.79474   -6.27538  12.17464  1.000 77.57542  ? 4   MET L CG  1 
ATOM   1633 S SD  . MET B 2 4   ? 9.53438   -5.21644  10.92350  1.000 88.83671  ? 4   MET L SD  1 
ATOM   1634 C CE  . MET B 2 4   ? 8.27757   -5.28781  9.64935   1.000 76.31505  ? 4   MET L CE  1 
ATOM   1635 N N   . THR B 2 5   ? 8.94963   -2.76756  15.53623  1.000 86.22715  ? 5   THR L N   1 
ATOM   1636 C CA  . THR B 2 5   ? 8.40111   -1.82751  16.50468  1.000 85.66279  ? 5   THR L CA  1 
ATOM   1637 C C   . THR B 2 5   ? 7.42504   -0.88435  15.81448  1.000 82.97565  ? 5   THR L C   1 
ATOM   1638 O O   . THR B 2 5   ? 7.81965   -0.09634  14.94840  1.000 86.88388  ? 5   THR L O   1 
ATOM   1639 C CB  . THR B 2 5   ? 9.52281   -1.04144  17.17235  1.000 87.58861  ? 5   THR L CB  1 
ATOM   1640 O OG1 . THR B 2 5   ? 10.41122  -1.95191  17.83560  1.000 72.22672  ? 5   THR L OG1 1 
ATOM   1641 C CG2 . THR B 2 5   ? 8.94209   -0.05653  18.17753  1.000 72.86739  ? 5   THR L CG2 1 
ATOM   1642 N N   . GLN B 2 6   ? 6.15803   -0.96198  16.20182  1.000 84.01814  ? 6   GLN L N   1 
ATOM   1643 C CA  . GLN B 2 6   ? 5.08536   -0.21019  15.57045  1.000 78.28201  ? 6   GLN L CA  1 
ATOM   1644 C C   . GLN B 2 6   ? 4.80368   1.06938   16.35305  1.000 78.77077  ? 6   GLN L C   1 
ATOM   1645 O O   . GLN B 2 6   ? 5.24673   1.23671   17.49403  1.000 82.27969  ? 6   GLN L O   1 
ATOM   1646 C CB  . GLN B 2 6   ? 3.82912   -1.08071  15.47606  1.000 76.42512  ? 6   GLN L CB  1 
ATOM   1647 C CG  . GLN B 2 6   ? 2.89803   -0.76033  14.32697  1.000 71.50093  ? 6   GLN L CG  1 
ATOM   1648 C CD  . GLN B 2 6   ? 1.97673   -1.92272  13.98905  1.000 62.43401  ? 6   GLN L CD  1 
ATOM   1649 O OE1 . GLN B 2 6   ? 2.39056   -3.08208  14.01684  1.000 57.99223  ? 6   GLN L OE1 1 
ATOM   1650 N NE2 . GLN B 2 6   ? 0.72245   -1.61611  13.66713  1.000 60.55721  ? 6   GLN L NE2 1 
ATOM   1651 N N   . SER B 2 7   ? 4.05612   1.98253   15.71816  1.000 78.62942  ? 7   SER L N   1 
ATOM   1652 C CA  . SER B 2 7   ? 3.74996   3.26045   16.34664  1.000 74.69384  ? 7   SER L CA  1 
ATOM   1653 C C   . SER B 2 7   ? 2.64908   3.97490   15.58217  1.000 85.67581  ? 7   SER L C   1 
ATOM   1654 O O   . SER B 2 7   ? 2.68674   3.99021   14.34358  1.000 91.00720  ? 7   SER L O   1 
ATOM   1655 C CB  . SER B 2 7   ? 4.99536   4.15090   16.40930  1.000 72.95663  ? 7   SER L CB  1 
ATOM   1656 O OG  . SER B 2 7   ? 4.66424   5.44530   16.87523  1.000 94.34467  ? 7   SER L OG  1 
ATOM   1657 N N   . PRO B 2 8   ? 1.66323   4.57587   16.26671  1.000 84.09131  ? 8   PRO L N   1 
ATOM   1658 C CA  . PRO B 2 8   ? 1.47720   4.49013   17.71753  1.000 79.18834  ? 8   PRO L CA  1 
ATOM   1659 C C   . PRO B 2 8   ? 0.79190   3.18459   18.09294  1.000 74.88116  ? 8   PRO L C   1 
ATOM   1660 O O   . PRO B 2 8   ? 0.25124   2.52186   17.21058  1.000 74.59724  ? 8   PRO L O   1 
ATOM   1661 C CB  . PRO B 2 8   ? 0.58289   5.68988   18.02222  1.000 78.69326  ? 8   PRO L CB  1 
ATOM   1662 C CG  . PRO B 2 8   ? -0.21857  5.86173   16.77979  1.000 82.79916  ? 8   PRO L CG  1 
ATOM   1663 C CD  . PRO B 2 8   ? 0.67413   5.46759   15.63272  1.000 84.01322  ? 8   PRO L CD  1 
ATOM   1664 N N   . SER B 2 9   ? 0.82585   2.80683   19.37194  1.000 75.10882  ? 9   SER L N   1 
ATOM   1665 C CA  . SER B 2 9   ? 0.16358   1.57427   19.78327  1.000 72.46533  ? 9   SER L CA  1 
ATOM   1666 C C   . SER B 2 9   ? -1.34000  1.64288   19.56310  1.000 77.60410  ? 9   SER L C   1 
ATOM   1667 O O   . SER B 2 9   ? -1.99001  0.59871   19.42864  1.000 67.27589  ? 9   SER L O   1 
ATOM   1668 C CB  . SER B 2 9   ? 0.47879   1.27445   21.24756  1.000 73.15230  ? 9   SER L CB  1 
ATOM   1669 O OG  . SER B 2 9   ? 0.22024   2.40343   22.05883  1.000 92.29734  ? 9   SER L OG  1 
ATOM   1670 N N   . SER B 2 10  ? -1.89328  2.85034   19.50078  1.000 85.78535  ? 10  SER L N   1 
ATOM   1671 C CA  . SER B 2 10  ? -3.30387  3.10198   19.24985  1.000 81.29713  ? 10  SER L CA  1 
ATOM   1672 C C   . SER B 2 10  ? -3.45097  4.56834   18.88762  1.000 74.93856  ? 10  SER L C   1 
ATOM   1673 O O   . SER B 2 10  ? -2.66959  5.40950   19.34039  1.000 78.96330  ? 10  SER L O   1 
ATOM   1674 C CB  . SER B 2 10  ? -4.16137  2.76885   20.47333  1.000 74.27915  ? 10  SER L CB  1 
ATOM   1675 O OG  . SER B 2 10  ? -3.63281  3.41648   21.61840  1.000 84.77766  ? 10  SER L OG  1 
ATOM   1676 N N   . LEU B 2 11  ? -4.45215  4.86474   18.06795  1.000 66.32660  ? 11  LEU L N   1 
ATOM   1677 C CA  . LEU B 2 11  ? -4.71180  6.24113   17.68852  1.000 65.41225  ? 11  LEU L CA  1 
ATOM   1678 C C   . LEU B 2 11  ? -6.20029  6.41793   17.43869  1.000 72.65197  ? 11  LEU L C   1 
ATOM   1679 O O   . LEU B 2 11  ? -6.93111  5.45805   17.17698  1.000 64.01283  ? 11  LEU L O   1 
ATOM   1680 C CB  . LEU B 2 11  ? -3.89815  6.64880   16.45508  1.000 69.29457  ? 11  LEU L CB  1 
ATOM   1681 C CG  . LEU B 2 11  ? -4.18224  5.89927   15.15303  1.000 78.11378  ? 11  LEU L CG  1 
ATOM   1682 C CD1 . LEU B 2 11  ? -5.24599  6.59822   14.31030  1.000 69.32475  ? 11  LEU L CD1 1 
ATOM   1683 C CD2 . LEU B 2 11  ? -2.89856  5.72500   14.36058  1.000 83.40121  ? 11  LEU L CD2 1 
ATOM   1684 N N   . SER B 2 12  ? -6.63450  7.67062   17.51765  1.000 64.87706  ? 12  SER L N   1 
ATOM   1685 C CA  . SER B 2 12  ? -8.02168  8.04151   17.30149  1.000 62.23859  ? 12  SER L CA  1 
ATOM   1686 C C   . SER B 2 12  ? -8.06016  9.14324   16.25261  1.000 74.94371  ? 12  SER L C   1 
ATOM   1687 O O   . SER B 2 12  ? -7.29627  10.11065  16.34114  1.000 67.08092  ? 12  SER L O   1 
ATOM   1688 C CB  . SER B 2 12  ? -8.66984  8.49886   18.61515  1.000 67.49407  ? 12  SER L CB  1 
ATOM   1689 O OG  . SER B 2 12  ? -10.08282 8.43972   18.55325  1.000 75.35962  ? 12  SER L OG  1 
ATOM   1690 N N   . ALA B 2 13  ? -8.93008  8.98582   15.25405  1.000 66.68714  ? 13  ALA L N   1 
ATOM   1691 C CA  . ALA B 2 13  ? -9.03277  9.94507   14.16308  1.000 73.18795  ? 13  ALA L CA  1 
ATOM   1692 C C   . ALA B 2 13  ? -10.40892 9.81480   13.53113  1.000 77.07781  ? 13  ALA L C   1 
ATOM   1693 O O   . ALA B 2 13  ? -10.91195 8.70287   13.36217  1.000 81.18342  ? 13  ALA L O   1 
ATOM   1694 C CB  . ALA B 2 13  ? -7.93767  9.72326   13.10983  1.000 74.26442  ? 13  ALA L CB  1 
ATOM   1695 N N   . SER B 2 14  ? -11.01330 10.94676  13.18502  1.000 74.16393  ? 14  SER L N   1 
ATOM   1696 C CA  . SER B 2 14  ? -12.34727 10.89714  12.61377  1.000 72.64766  ? 14  SER L CA  1 
ATOM   1697 C C   . SER B 2 14  ? -12.27965 10.53218  11.13144  1.000 71.56724  ? 14  SER L C   1 
ATOM   1698 O O   . SER B 2 14  ? -11.20476 10.38724  10.54160  1.000 69.28645  ? 14  SER L O   1 
ATOM   1699 C CB  . SER B 2 14  ? -13.07191 12.22365  12.82247  1.000 76.31639  ? 14  SER L CB  1 
ATOM   1700 O OG  . SER B 2 14  ? -14.46948 12.05798  12.62643  1.000 82.17967  ? 14  SER L OG  1 
ATOM   1701 N N   . VAL B 2 15  ? -13.46149 10.37869  10.52793  1.000 66.36320  ? 15  VAL L N   1 
ATOM   1702 C CA  . VAL B 2 15  ? -13.55663 9.98136   9.12949   1.000 66.01192  ? 15  VAL L CA  1 
ATOM   1703 C C   . VAL B 2 15  ? -12.88263 11.01986  8.24310   1.000 80.00618  ? 15  VAL L C   1 
ATOM   1704 O O   . VAL B 2 15  ? -12.90110 12.22384  8.52995   1.000 77.91266  ? 15  VAL L O   1 
ATOM   1705 C CB  . VAL B 2 15  ? -15.03163 9.78769   8.74091   1.000 57.93609  ? 15  VAL L CB  1 
ATOM   1706 C CG1 . VAL B 2 15  ? -15.16134 9.25486   7.32404   1.000 68.16024  ? 15  VAL L CG1 1 
ATOM   1707 C CG2 . VAL B 2 15  ? -15.71642 8.85956   9.72830   1.000 72.76311  ? 15  VAL L CG2 1 
ATOM   1708 N N   . GLY B 2 16  ? -12.26985 10.55072  7.15756   1.000 80.87663  ? 16  GLY L N   1 
ATOM   1709 C CA  . GLY B 2 16  ? -11.61807 11.41857  6.20551   1.000 73.71755  ? 16  GLY L CA  1 
ATOM   1710 C C   . GLY B 2 16  ? -10.21260 11.82789  6.57642   1.000 80.78057  ? 16  GLY L C   1 
ATOM   1711 O O   . GLY B 2 16  ? -9.48417  12.32536  5.70811   1.000 82.18142  ? 16  GLY L O   1 
ATOM   1712 N N   . ASP B 2 17  ? -9.81029  11.63475  7.83197   1.000 85.01487  ? 17  ASP L N   1 
ATOM   1713 C CA  . ASP B 2 17  ? -8.46320  11.96871  8.26461   1.000 85.30813  ? 17  ASP L CA  1 
ATOM   1714 C C   . ASP B 2 17  ? -7.42952  11.14927  7.49790   1.000 81.34207  ? 17  ASP L C   1 
ATOM   1715 O O   . ASP B 2 17  ? -7.73111  10.11684  6.89041   1.000 79.87714  ? 17  ASP L O   1 
ATOM   1716 C CB  . ASP B 2 17  ? -8.29373  11.72391  9.76664   1.000 75.96917  ? 17  ASP L CB  1 
ATOM   1717 C CG  . ASP B 2 17  ? -9.15485  12.63581  10.61079  1.000 79.89324  ? 17  ASP L CG  1 
ATOM   1718 O OD1 . ASP B 2 17  ? -10.08503 13.25846  10.05194  1.000 76.57182  ? 17  ASP L OD1 1 
ATOM   1719 O OD2 . ASP B 2 17  ? -8.89640  12.72758  11.83246  1.000 83.17612  ? 17  ASP L OD2 1 
ATOM   1720 N N   . ARG B 2 18  ? -6.19417  11.63706  7.52444   1.000 78.12692  ? 18  ARG L N   1 
ATOM   1721 C CA  . ARG B 2 18  ? -5.05595  10.93483  6.94843   1.000 80.37914  ? 18  ARG L CA  1 
ATOM   1722 C C   . ARG B 2 18  ? -4.27259  10.31859  8.09934   1.000 81.24129  ? 18  ARG L C   1 
ATOM   1723 O O   . ARG B 2 18  ? -3.67169  11.03500  8.90782   1.000 80.27909  ? 18  ARG L O   1 
ATOM   1724 C CB  . ARG B 2 18  ? -4.18910  11.87799  6.11616   1.000 84.57960  ? 18  ARG L CB  1 
ATOM   1725 C CG  . ARG B 2 18  ? -3.05413  11.19758  5.35576   1.000 84.36277  ? 18  ARG L CG  1 
ATOM   1726 C CD  . ARG B 2 18  ? -2.14712  12.22754  4.69350   1.000 74.17723  ? 18  ARG L CD  1 
ATOM   1727 N NE  . ARG B 2 18  ? -0.97075  11.61819  4.08634   1.000 89.25175  ? 18  ARG L NE  1 
ATOM   1728 C CZ  . ARG B 2 18  ? -0.87361  11.28884  2.80578   1.000 83.85129  ? 18  ARG L CZ  1 
ATOM   1729 N NH1 . ARG B 2 18  ? -1.86811  11.50277  1.95981   1.000 76.26170  ? 18  ARG L NH1 1 
ATOM   1730 N NH2 . ARG B 2 18  ? 0.25109   10.73356  2.36269   1.000 81.27019  ? 18  ARG L NH2 1 
ATOM   1731 N N   . VAL B 2 19  ? -4.29811  8.99503   8.17939   1.000 77.83766  ? 19  VAL L N   1 
ATOM   1732 C CA  . VAL B 2 19  ? -3.65422  8.25260   9.25455   1.000 79.86392  ? 19  VAL L CA  1 
ATOM   1733 C C   . VAL B 2 19  ? -2.31301  7.73863   8.75973   1.000 76.55080  ? 19  VAL L C   1 
ATOM   1734 O O   . VAL B 2 19  ? -2.18400  7.29774   7.60979   1.000 70.70006  ? 19  VAL L O   1 
ATOM   1735 C CB  . VAL B 2 19  ? -4.55142  7.09687   9.73927   1.000 72.29685  ? 19  VAL L CB  1 
ATOM   1736 C CG1 . VAL B 2 19  ? -3.84825  6.28229   10.81475  1.000 76.34722  ? 19  VAL L CG1 1 
ATOM   1737 C CG2 . VAL B 2 19  ? -5.86951  7.63681   10.25823  1.000 76.58223  ? 19  VAL L CG2 1 
ATOM   1738 N N   . THR B 2 20  ? -1.30816  7.79564   9.62586   1.000 70.92300  ? 20  THR L N   1 
ATOM   1739 C CA  . THR B 2 20  ? 0.02284   7.30851   9.29236   1.000 72.16444  ? 20  THR L CA  1 
ATOM   1740 C C   . THR B 2 20  ? 0.50136   6.39888   10.41305  1.000 82.79811  ? 20  THR L C   1 
ATOM   1741 O O   . THR B 2 20  ? 0.76220   6.86037   11.53059  1.000 84.17555  ? 20  THR L O   1 
ATOM   1742 C CB  . THR B 2 20  ? 0.99228   8.46430   9.06183   1.000 82.09226  ? 20  THR L CB  1 
ATOM   1743 O OG1 . THR B 2 20  ? 0.60560   9.17162   7.87510   1.000 80.06372  ? 20  THR L OG1 1 
ATOM   1744 C CG2 . THR B 2 20  ? 2.40946   7.94275   8.89433   1.000 76.06932  ? 20  THR L CG2 1 
ATOM   1745 N N   . ILE B 2 21  ? 0.59016   5.10692   10.10679  1.000 83.81051  ? 21  ILE L N   1 
ATOM   1746 C CA  . ILE B 2 21  ? 1.13442   4.09309   11.00100  1.000 72.30277  ? 21  ILE L CA  1 
ATOM   1747 C C   . ILE B 2 21  ? 2.52720   3.74628   10.50594  1.000 74.35470  ? 21  ILE L C   1 
ATOM   1748 O O   . ILE B 2 21  ? 2.72393   3.50811   9.30828   1.000 81.06126  ? 21  ILE L O   1 
ATOM   1749 C CB  . ILE B 2 21  ? 0.23814   2.84272   11.03556  1.000 72.24702  ? 21  ILE L CB  1 
ATOM   1750 C CG1 . ILE B 2 21  ? -1.18347  3.20926   11.47532  1.000 70.99813  ? 21  ILE L CG1 1 
ATOM   1751 C CG2 . ILE B 2 21  ? 0.83632   1.76888   11.93029  1.000 68.84266  ? 21  ILE L CG2 1 
ATOM   1752 C CD1 . ILE B 2 21  ? -2.17257  2.09623   11.29320  1.000 55.71621  ? 21  ILE L CD1 1 
ATOM   1753 N N   . THR B 2 22  ? 3.49179   3.72498   11.41706  1.000 84.05913  ? 22  THR L N   1 
ATOM   1754 C CA  . THR B 2 22  ? 4.88490   3.45759   11.09667  1.000 77.05670  ? 22  THR L CA  1 
ATOM   1755 C C   . THR B 2 22  ? 5.32426   2.13956   11.72259  1.000 80.98688  ? 22  THR L C   1 
ATOM   1756 O O   . THR B 2 22  ? 4.71556   1.64125   12.67182  1.000 85.22757  ? 22  THR L O   1 
ATOM   1757 C CB  . THR B 2 22  ? 5.78404   4.59656   11.58925  1.000 84.81610  ? 22  THR L CB  1 
ATOM   1758 O OG1 . THR B 2 22  ? 5.65574   4.72339   13.01234  1.000 93.18895  ? 22  THR L OG1 1 
ATOM   1759 C CG2 . THR B 2 22  ? 5.38591   5.91563   10.93077  1.000 84.58322  ? 22  THR L CG2 1 
ATOM   1760 N N   . CYS B 2 23  ? 6.40618   1.58358   11.18483  1.000 82.93538  ? 23  CYS L N   1 
ATOM   1761 C CA  . CYS B 2 23  ? 6.92147   0.29424   11.64103  1.000 78.62866  ? 23  CYS L CA  1 
ATOM   1762 C C   . CYS B 2 23  ? 8.42302   0.29079   11.38193  1.000 91.55320  ? 23  CYS L C   1 
ATOM   1763 O O   . CYS B 2 23  ? 8.85183   0.41471   10.23067  1.000 94.38778  ? 23  CYS L O   1 
ATOM   1764 C CB  . CYS B 2 23  ? 6.20870   -0.85388  10.91483  1.000 84.12059  ? 23  CYS L CB  1 
ATOM   1765 S SG  . CYS B 2 23  ? 6.59975   -2.57787  11.38876  1.000 99.74881  ? 23  CYS L SG  1 
ATOM   1766 N N   . ARG B 2 24  ? 9.21478   0.18328   12.44693  1.000 99.52572  ? 24  ARG L N   1 
ATOM   1767 C CA  . ARG B 2 24  ? 10.66997  0.19521   12.37052  1.000 87.97318  ? 24  ARG L CA  1 
ATOM   1768 C C   . ARG B 2 24  ? 11.23196  -1.21451  12.49950  1.000 90.97163  ? 24  ARG L C   1 
ATOM   1769 O O   . ARG B 2 24  ? 10.58814  -2.12217  13.03090  1.000 95.19949  ? 24  ARG L O   1 
ATOM   1770 C CB  . ARG B 2 24  ? 11.27416  1.06769   13.47343  1.000 99.80557  ? 24  ARG L CB  1 
ATOM   1771 C CG  . ARG B 2 24  ? 11.20916  2.55619   13.23845  1.000 99.67277  ? 24  ARG L CG  1 
ATOM   1772 C CD  . ARG B 2 24  ? 11.75125  3.28426   14.45256  1.000 103.24296 ? 24  ARG L CD  1 
ATOM   1773 N NE  . ARG B 2 24  ? 11.83180  4.72212   14.23966  1.000 108.06651 ? 24  ARG L NE  1 
ATOM   1774 C CZ  . ARG B 2 24  ? 12.24634  5.58792   15.15366  1.000 111.00910 ? 24  ARG L CZ  1 
ATOM   1775 N NH1 . ARG B 2 24  ? 12.62171  5.19262   16.35912  1.000 103.31258 ? 24  ARG L NH1 1 
ATOM   1776 N NH2 . ARG B 2 24  ? 12.28458  6.88267   14.85120  1.000 109.71043 ? 24  ARG L NH2 1 
ATOM   1777 N N   . ALA B 2 25  ? 12.45889  -1.38461  12.01857  1.000 89.95098  ? 25  ALA L N   1 
ATOM   1778 C CA  . ALA B 2 25  ? 13.22210  -2.60266  12.24665  1.000 91.37674  ? 25  ALA L CA  1 
ATOM   1779 C C   . ALA B 2 25  ? 14.21483  -2.32153  13.36605  1.000 99.96229  ? 25  ALA L C   1 
ATOM   1780 O O   . ALA B 2 25  ? 14.94804  -1.32832  13.31136  1.000 108.51709 ? 25  ALA L O   1 
ATOM   1781 C CB  . ALA B 2 25  ? 13.94058  -3.05798  10.97738  1.000 93.86294  ? 25  ALA L CB  1 
ATOM   1782 N N   . SER B 2 26  ? 14.21550  -3.18017  14.38927  1.000 106.94916 ? 26  SER L N   1 
ATOM   1783 C CA  . SER B 2 26  ? 15.10054  -2.98470  15.53590  1.000 106.02146 ? 26  SER L CA  1 
ATOM   1784 C C   . SER B 2 26  ? 16.55733  -2.92031  15.09608  1.000 115.92405 ? 26  SER L C   1 
ATOM   1785 O O   . SER B 2 26  ? 17.28793  -1.98538  15.44747  1.000 106.81163 ? 26  SER L O   1 
ATOM   1786 C CB  . SER B 2 26  ? 14.89606  -4.11052  16.55311  1.000 96.98720  ? 26  SER L CB  1 
ATOM   1787 O OG  . SER B 2 26  ? 15.20448  -5.37628  15.98925  1.000 90.72426  ? 26  SER L OG  1 
ATOM   1788 N N   . GLN B 2 27  ? 16.99284  -3.90960  14.31768  1.000 119.48430 ? 27  GLN L N   1 
ATOM   1789 C CA  . GLN B 2 27  ? 18.33891  -3.93099  13.76736  1.000 115.62294 ? 27  GLN L CA  1 
ATOM   1790 C C   . GLN B 2 27  ? 18.36595  -3.16723  12.44977  1.000 110.77877 ? 27  GLN L C   1 
ATOM   1791 O O   . GLN B 2 27  ? 17.72909  -2.11797  12.31477  1.000 108.67194 ? 27  GLN L O   1 
ATOM   1792 C CB  . GLN B 2 27  ? 18.80762  -5.37575  13.57164  1.000 112.42789 ? 27  GLN L CB  1 
ATOM   1793 C CG  . GLN B 2 27  ? 18.41033  -6.32692  14.69888  1.000 97.78883  ? 27  GLN L CG  1 
ATOM   1794 C CD  . GLN B 2 27  ? 18.44071  -7.77831  14.26208  1.000 103.54703 ? 27  GLN L CD  1 
ATOM   1795 O OE1 . GLN B 2 27  ? 18.09720  -8.09999  13.12393  1.000 114.88167 ? 27  GLN L OE1 1 
ATOM   1796 N NE2 . GLN B 2 27  ? 18.86220  -8.66283  15.16133  1.000 96.01293  ? 27  GLN L NE2 1 
ATOM   1797 N N   . SER B 2 28  A 19.09685  -3.68819  11.47075  1.000 110.30093 ? 27  SER L N   1 
ATOM   1798 C CA  . SER B 2 28  A 19.18601  -3.05020  10.16119  1.000 116.93288 ? 27  SER L CA  1 
ATOM   1799 C C   . SER B 2 28  A 19.42925  -4.16149  9.14730   1.000 117.95554 ? 27  SER L C   1 
ATOM   1800 O O   . SER B 2 28  A 20.50989  -4.75142  9.11194   1.000 118.61787 ? 27  SER L O   1 
ATOM   1801 C CB  . SER B 2 28  A 20.28640  -2.00038  10.12731  1.000 115.52351 ? 27  SER L CB  1 
ATOM   1802 O OG  . SER B 2 28  A 19.88180  -0.81997  10.77991  1.000 115.12159 ? 27  SER L OG  1 
ATOM   1803 N N   . VAL B 2 29  B 18.41769  -4.45656  8.34414   1.000 112.07532 ? 27  VAL L N   1 
ATOM   1804 C CA  . VAL B 2 29  B 18.54434  -5.47479  7.31097   1.000 111.71691 ? 27  VAL L CA  1 
ATOM   1805 C C   . VAL B 2 29  B 18.78053  -4.73994  6.00860   1.000 115.46996 ? 27  VAL L C   1 
ATOM   1806 O O   . VAL B 2 29  B 18.66226  -5.31548  4.91796   1.000 115.33738 ? 27  VAL L O   1 
ATOM   1807 C CB  . VAL B 2 29  B 17.29573  -6.36860  7.26825   1.000 110.78515 ? 27  VAL L CB  1 
ATOM   1808 C CG1 . VAL B 2 29  B 17.14744  -7.06775  8.60992   1.000 102.92970 ? 27  VAL L CG1 1 
ATOM   1809 C CG2 . VAL B 2 29  B 16.08179  -5.51466  6.94693   1.000 107.81455 ? 27  VAL L CG2 1 
ATOM   1810 N N   . TRP B 2 30  ? 19.10411  -3.45129  6.14310   1.000 114.68285 ? 28  TRP L N   1 
ATOM   1811 C CA  . TRP B 2 30  ? 19.50137  -2.59593  5.03511   1.000 115.74885 ? 28  TRP L CA  1 
ATOM   1812 C C   . TRP B 2 30  ? 18.33218  -2.38356  4.08247   1.000 113.14725 ? 28  TRP L C   1 
ATOM   1813 O O   . TRP B 2 30  ? 17.78584  -1.27738  3.98566   1.000 108.54132 ? 28  TRP L O   1 
ATOM   1814 C CB  . TRP B 2 30  ? 20.71176  -3.19084  4.29888   1.000 115.67793 ? 28  TRP L CB  1 
ATOM   1815 C CG  . TRP B 2 30  ? 21.65263  -3.91277  5.22156   1.000 119.35707 ? 28  TRP L CG  1 
ATOM   1816 C CD1 . TRP B 2 30  ? 22.02044  -5.22575  5.15470   1.000 118.51223 ? 28  TRP L CD1 1 
ATOM   1817 C CD2 . TRP B 2 30  ? 22.32446  -3.36672  6.36513   1.000 129.29470 ? 28  TRP L CD2 1 
ATOM   1818 N NE1 . TRP B 2 30  ? 22.88619  -5.52997  6.17574   1.000 122.68917 ? 28  TRP L NE1 1 
ATOM   1819 C CE2 . TRP B 2 30  ? 23.09082  -4.40691  6.93392   1.000 134.04520 ? 28  TRP L CE2 1 
ATOM   1820 C CE3 . TRP B 2 30  ? 22.35786  -2.09917  6.96109   1.000 125.26275 ? 28  TRP L CE3 1 
ATOM   1821 C CZ2 . TRP B 2 30  ? 23.88243  -4.21848  8.06906   1.000 135.71498 ? 28  TRP L CZ2 1 
ATOM   1822 C CZ3 . TRP B 2 30  ? 23.14506  -1.91548  8.08809   1.000 130.97388 ? 28  TRP L CZ3 1 
ATOM   1823 C CH2 . TRP B 2 30  ? 23.89512  -2.96839  8.62904   1.000 131.53901 ? 28  TRP L CH2 1 
ATOM   1824 N N   . ARG B 2 31  ? 17.92371  -3.44582  3.39655   1.000 107.95393 ? 29  ARG L N   1 
ATOM   1825 C CA  . ARG B 2 31  ? 16.84733  -3.34796  2.42212   1.000 97.82187  ? 29  ARG L CA  1 
ATOM   1826 C C   . ARG B 2 31  ? 16.07406  -4.65491  2.46104   1.000 96.98099  ? 29  ARG L C   1 
ATOM   1827 O O   . ARG B 2 31  ? 16.61298  -5.70337  2.09541   1.000 99.10118  ? 29  ARG L O   1 
ATOM   1828 C CB  . ARG B 2 31  ? 17.41093  -3.07053  1.03618   1.000 96.18508  ? 29  ARG L CB  1 
ATOM   1829 C CG  . ARG B 2 31  ? 16.36285  -2.79427  -0.00266  1.000 90.66796  ? 29  ARG L CG  1 
ATOM   1830 C CD  . ARG B 2 31  ? 16.61352  -1.46562  -0.68811  1.000 101.34172 ? 29  ARG L CD  1 
ATOM   1831 N NE  . ARG B 2 31  ? 16.33336  -1.55069  -2.11685  1.000 110.36473 ? 29  ARG L NE  1 
ATOM   1832 C CZ  . ARG B 2 31  ? 17.24164  -1.84040  -3.03922  1.000 97.95843  ? 29  ARG L CZ  1 
ATOM   1833 N NH1 . ARG B 2 31  ? 18.50762  -2.04655  -2.71973  1.000 95.42979  ? 29  ARG L NH1 1 
ATOM   1834 N NH2 . ARG B 2 31  ? 16.86978  -1.92878  -4.31308  1.000 84.73528  ? 29  ARG L NH2 1 
ATOM   1835 N N   . ASN B 2 32  ? 14.82589  -4.59409  2.91224   1.000 91.72115  ? 30  ASN L N   1 
ATOM   1836 C CA  . ASN B 2 32  ? 13.95288  -5.75680  2.93614   1.000 80.46734  ? 30  ASN L CA  1 
ATOM   1837 C C   . ASN B 2 32  ? 12.71093  -5.44415  2.11968   1.000 79.31140  ? 30  ASN L C   1 
ATOM   1838 O O   . ASN B 2 32  ? 12.04531  -4.43204  2.35966   1.000 77.72504  ? 30  ASN L O   1 
ATOM   1839 C CB  . ASN B 2 32  ? 13.57924  -6.14765  4.36607   1.000 90.52836  ? 30  ASN L CB  1 
ATOM   1840 C CG  . ASN B 2 32  ? 12.66045  -7.35385  4.41214   1.000 88.33516  ? 30  ASN L CG  1 
ATOM   1841 O OD1 . ASN B 2 32  ? 11.46661  -7.22765  4.68582   1.000 86.30123  ? 30  ASN L OD1 1 
ATOM   1842 N ND2 . ASN B 2 32  ? 13.21099  -8.53203  4.12671   1.000 79.77653  ? 30  ASN L ND2 1 
ATOM   1843 N N   . LYS B 2 33  ? 12.40921  -6.31084  1.15442   1.000 85.11588  ? 31  LYS L N   1 
ATOM   1844 C CA  . LYS B 2 33  ? 11.23162  -6.16488  0.30988   1.000 73.25067  ? 31  LYS L CA  1 
ATOM   1845 C C   . LYS B 2 33  ? 10.00930  -6.87361  0.87883   1.000 73.53582  ? 31  LYS L C   1 
ATOM   1846 O O   . LYS B 2 33  ? 8.88363   -6.40566  0.67484   1.000 75.14054  ? 31  LYS L O   1 
ATOM   1847 C CB  . LYS B 2 33  ? 11.53109  -6.69883  -1.09645  1.000 66.80910  ? 31  LYS L CB  1 
ATOM   1848 C CG  . LYS B 2 33  ? 10.31674  -6.78547  -2.02309  1.000 87.55404  ? 31  LYS L CG  1 
ATOM   1849 C CD  . LYS B 2 33  ? 10.66238  -7.41933  -3.37370  1.000 90.75514  ? 31  LYS L CD  1 
ATOM   1850 C CE  . LYS B 2 33  ? 9.47464   -7.38773  -4.33399  1.000 83.50615  ? 31  LYS L CE  1 
ATOM   1851 N NZ  . LYS B 2 33  ? 9.78593   -8.02655  -5.64480  1.000 90.95939  ? 31  LYS L NZ  1 
ATOM   1852 N N   . ASN B 2 34  ? 10.20139  -7.98001  1.60158   1.000 72.83159  ? 32  ASN L N   1 
ATOM   1853 C CA  . ASN B 2 34  ? 9.09101   -8.80936  2.07383   1.000 69.64099  ? 32  ASN L CA  1 
ATOM   1854 C C   . ASN B 2 34  ? 8.49956   -8.27356  3.37811   1.000 76.49697  ? 32  ASN L C   1 
ATOM   1855 O O   . ASN B 2 34  ? 8.48799   -8.93749  4.41596   1.000 69.73034  ? 32  ASN L O   1 
ATOM   1856 C CB  . ASN B 2 34  ? 9.54285   -10.24857 2.25862   1.000 71.64510  ? 32  ASN L CB  1 
ATOM   1857 C CG  . ASN B 2 34  ? 10.22869  -10.79577 1.04583   1.000 74.00580  ? 32  ASN L CG  1 
ATOM   1858 O OD1 . ASN B 2 34  ? 9.59217   -11.07645 0.03034   1.000 69.36251  ? 32  ASN L OD1 1 
ATOM   1859 N ND2 . ASN B 2 34  ? 11.54202  -10.96256 1.14100   1.000 74.16754  ? 32  ASN L ND2 1 
ATOM   1860 N N   . VAL B 2 35  ? 7.99301   -7.04815  3.30503   1.000 75.76434  ? 33  VAL L N   1 
ATOM   1861 C CA  . VAL B 2 35  ? 7.22799   -6.44703  4.38840   1.000 64.68204  ? 33  VAL L CA  1 
ATOM   1862 C C   . VAL B 2 35  ? 5.79103   -6.30683  3.91790   1.000 66.73832  ? 33  VAL L C   1 
ATOM   1863 O O   . VAL B 2 35  ? 5.54151   -5.89534  2.77842   1.000 67.00572  ? 33  VAL L O   1 
ATOM   1864 C CB  . VAL B 2 35  ? 7.80926   -5.09110  4.82055   1.000 62.68753  ? 33  VAL L CB  1 
ATOM   1865 C CG1 . VAL B 2 35  ? 6.77092   -4.28892  5.58481   1.000 60.28678  ? 33  VAL L CG1 1 
ATOM   1866 C CG2 . VAL B 2 35  ? 9.04662   -5.31580  5.67370   1.000 66.65241  ? 33  VAL L CG2 1 
ATOM   1867 N N   . ALA B 2 36  ? 4.85365   -6.68176  4.77701   1.000 58.65657  ? 34  ALA L N   1 
ATOM   1868 C CA  . ALA B 2 36  ? 3.44208   -6.59464  4.45854   1.000 56.14186  ? 34  ALA L CA  1 
ATOM   1869 C C   . ALA B 2 36  ? 2.72178   -5.78505  5.52608   1.000 53.47878  ? 34  ALA L C   1 
ATOM   1870 O O   . ALA B 2 36  ? 3.27323   -5.45117  6.57791   1.000 53.73745  ? 34  ALA L O   1 
ATOM   1871 C CB  . ALA B 2 36  ? 2.81257   -7.98791  4.33429   1.000 57.98869  ? 34  ALA L CB  1 
ATOM   1872 N N   . TRP B 2 37  ? 1.47004   -5.46538  5.22768   1.000 53.47126  ? 35  TRP L N   1 
ATOM   1873 C CA  . TRP B 2 37  ? 0.57974   -4.80310  6.16203   1.000 46.72754  ? 35  TRP L CA  1 
ATOM   1874 C C   . TRP B 2 37  ? -0.71655  -5.58432  6.20558   1.000 51.22881  ? 35  TRP L C   1 
ATOM   1875 O O   . TRP B 2 37  ? -1.30520  -5.88572  5.16053   1.000 44.75702  ? 35  TRP L O   1 
ATOM   1876 C CB  . TRP B 2 37  ? 0.32295   -3.35329  5.76486   1.000 51.23297  ? 35  TRP L CB  1 
ATOM   1877 C CG  . TRP B 2 37  ? 1.48012   -2.46828  6.05569   1.000 59.20266  ? 35  TRP L CG  1 
ATOM   1878 C CD1 . TRP B 2 37  ? 2.47177   -2.09738  5.19162   1.000 62.65387  ? 35  TRP L CD1 1 
ATOM   1879 C CD2 . TRP B 2 37  ? 1.78475   -1.84589  7.30682   1.000 65.94862  ? 35  TRP L CD2 1 
ATOM   1880 N NE1 . TRP B 2 37  ? 3.37139   -1.27660  5.82866   1.000 65.18742  ? 35  TRP L NE1 1 
ATOM   1881 C CE2 . TRP B 2 37  ? 2.96995   -1.10687  7.12863   1.000 69.58766  ? 35  TRP L CE2 1 
ATOM   1882 C CE3 . TRP B 2 37  ? 1.16894   -1.83882  8.56223   1.000 62.86096  ? 35  TRP L CE3 1 
ATOM   1883 C CZ2 . TRP B 2 37  ? 3.54675   -0.36695  8.15959   1.000 72.23950  ? 35  TRP L CZ2 1 
ATOM   1884 C CZ3 . TRP B 2 37  ? 1.74577   -1.10407  9.58378   1.000 57.43410  ? 35  TRP L CZ3 1 
ATOM   1885 C CH2 . TRP B 2 37  ? 2.91730   -0.37913  9.37593   1.000 67.90846  ? 35  TRP L CH2 1 
ATOM   1886 N N   . TYR B 2 38  ? -1.13684  -5.92657  7.41302   1.000 49.47789  ? 36  TYR L N   1 
ATOM   1887 C CA  . TYR B 2 38  ? -2.34349  -6.69454  7.64509   1.000 47.74053  ? 36  TYR L CA  1 
ATOM   1888 C C   . TYR B 2 38  ? -3.34483  -5.87050  8.43817   1.000 50.67658  ? 36  TYR L C   1 
ATOM   1889 O O   . TYR B 2 38  ? -2.98525  -4.95786  9.18853   1.000 52.54763  ? 36  TYR L O   1 
ATOM   1890 C CB  . TYR B 2 38  ? -2.02926  -7.98678  8.40122   1.000 53.86101  ? 36  TYR L CB  1 
ATOM   1891 C CG  . TYR B 2 38  ? -1.68688  -9.16098  7.52188   1.000 49.14274  ? 36  TYR L CG  1 
ATOM   1892 C CD1 . TYR B 2 38  ? -0.39942  -9.33573  7.02603   1.000 43.00585  ? 36  TYR L CD1 1 
ATOM   1893 C CD2 . TYR B 2 38  ? -2.64842  -10.10544 7.20452   1.000 44.49887  ? 36  TYR L CD2 1 
ATOM   1894 C CE1 . TYR B 2 38  ? -0.08517  -10.42240 6.23239   1.000 43.25756  ? 36  TYR L CE1 1 
ATOM   1895 C CE2 . TYR B 2 38  ? -2.34590  -11.18473 6.41294   1.000 52.33604  ? 36  TYR L CE2 1 
ATOM   1896 C CZ  . TYR B 2 38  ? -1.06851  -11.34075 5.92652   1.000 48.69468  ? 36  TYR L CZ  1 
ATOM   1897 O OH  . TYR B 2 38  ? -0.79531  -12.43441 5.13906   1.000 50.20127  ? 36  TYR L OH  1 
ATOM   1898 N N   . GLN B 2 39  ? -4.61385  -6.22032  8.26761   1.000 51.98306  ? 37  GLN L N   1 
ATOM   1899 C CA  . GLN B 2 39  ? -5.70971  -5.60321  8.99586   1.000 53.67526  ? 37  GLN L CA  1 
ATOM   1900 C C   . GLN B 2 39  ? -6.53987  -6.69248  9.65764   1.000 53.49006  ? 37  GLN L C   1 
ATOM   1901 O O   . GLN B 2 39  ? -6.77479  -7.74822  9.06387   1.000 66.46092  ? 37  GLN L O   1 
ATOM   1902 C CB  . GLN B 2 39  ? -6.58310  -4.76152  8.06501   1.000 51.14344  ? 37  GLN L CB  1 
ATOM   1903 C CG  . GLN B 2 39  ? -7.81179  -4.17240  8.73077   1.000 55.68044  ? 37  GLN L CG  1 
ATOM   1904 C CD  . GLN B 2 39  ? -8.84181  -3.74037  7.71898   1.000 54.89352  ? 37  GLN L CD  1 
ATOM   1905 O OE1 . GLN B 2 39  ? -9.57484  -4.56798  7.17311   1.000 61.18482  ? 37  GLN L OE1 1 
ATOM   1906 N NE2 . GLN B 2 39  ? -8.88865  -2.44171  7.43853   1.000 53.75546  ? 37  GLN L NE2 1 
ATOM   1907 N N   . GLN B 2 40  ? -6.98625  -6.43933  10.88515  1.000 55.31525  ? 38  GLN L N   1 
ATOM   1908 C CA  . GLN B 2 40  ? -7.76531  -7.41462  11.63744  1.000 59.37898  ? 38  GLN L CA  1 
ATOM   1909 C C   . GLN B 2 40  ? -8.91437  -6.71262  12.33882  1.000 54.39504  ? 38  GLN L C   1 
ATOM   1910 O O   . GLN B 2 40  ? -8.69175  -5.82465  13.16698  1.000 64.33056  ? 38  GLN L O   1 
ATOM   1911 C CB  . GLN B 2 40  ? -6.89960  -8.14745  12.65892  1.000 61.49693  ? 38  GLN L CB  1 
ATOM   1912 C CG  . GLN B 2 40  ? -7.58507  -9.34955  13.25658  1.000 53.68430  ? 38  GLN L CG  1 
ATOM   1913 C CD  . GLN B 2 40  ? -6.76190  -9.99074  14.33176  1.000 55.36435  ? 38  GLN L CD  1 
ATOM   1914 O OE1 . GLN B 2 40  ? -6.06600  -9.31034  15.08385  1.000 64.05986  ? 38  GLN L OE1 1 
ATOM   1915 N NE2 . GLN B 2 40  ? -6.83191  -11.31106 14.41576  1.000 61.58969  ? 38  GLN L NE2 1 
ATOM   1916 N N   . LYS B 2 41  ? -10.06440 -7.09666  12.03530  1.000 62.80175  ? 39  LYS L N   1 
ATOM   1917 C CA  . LYS B 2 41  ? -11.27250 -6.58428  12.64991  1.000 66.87357  ? 39  LYS L CA  1 
ATOM   1918 C C   . LYS B 2 41  ? -11.63327 -7.42666  13.87244  1.000 71.53602  ? 39  LYS L C   1 
ATOM   1919 O O   . LYS B 2 41  ? -11.27024 -8.60520  13.94289  1.000 66.42233  ? 39  LYS L O   1 
ATOM   1920 C CB  . LYS B 2 41  ? -12.41371 -6.58798  11.62927  1.000 64.09858  ? 39  LYS L CB  1 
ATOM   1921 C CG  . LYS B 2 41  ? -12.42505 -5.35308  10.71814  1.000 59.90078  ? 39  LYS L CG  1 
ATOM   1922 C CD  . LYS B 2 41  ? -13.17807 -5.56240  9.39564   1.000 63.14717  ? 39  LYS L CD  1 
ATOM   1923 C CE  . LYS B 2 41  ? -12.41436 -6.50504  8.45986   1.000 75.74864  ? 39  LYS L CE  1 
ATOM   1924 N NZ  . LYS B 2 41  ? -12.60551 -6.21443  7.00517   1.000 68.57875  ? 39  LYS L NZ  1 
ATOM   1925 N N   . PRO B 2 42  ? -12.31106 -6.83673  14.86218  1.000 73.46141  ? 40  PRO L N   1 
ATOM   1926 C CA  . PRO B 2 42  ? -12.65820 -7.58950  16.07641  1.000 71.62503  ? 40  PRO L CA  1 
ATOM   1927 C C   . PRO B 2 42  ? -13.34541 -8.90621  15.74962  1.000 72.49400  ? 40  PRO L C   1 
ATOM   1928 O O   . PRO B 2 42  ? -14.31909 -8.94947  14.99160  1.000 57.08787  ? 40  PRO L O   1 
ATOM   1929 C CB  . PRO B 2 42  ? -13.59470 -6.63604  16.82696  1.000 63.84212  ? 40  PRO L CB  1 
ATOM   1930 C CG  . PRO B 2 42  ? -13.16085 -5.28507  16.39842  1.000 72.12228  ? 40  PRO L CG  1 
ATOM   1931 C CD  . PRO B 2 42  ? -12.73487 -5.42840  14.95518  1.000 82.10392  ? 40  PRO L CD  1 
ATOM   1932 N N   . GLY B 2 43  ? -12.81003 -9.98849  16.31770  1.000 66.33278  ? 41  GLY L N   1 
ATOM   1933 C CA  . GLY B 2 43  ? -13.34754 -11.31170 16.08003  1.000 57.68867  ? 41  GLY L CA  1 
ATOM   1934 C C   . GLY B 2 43  ? -13.19134 -11.83343 14.67089  1.000 69.73838  ? 41  GLY L C   1 
ATOM   1935 O O   . GLY B 2 43  ? -13.87969 -12.78756 14.30356  1.000 75.20034  ? 41  GLY L O   1 
ATOM   1936 N N   . LYS B 2 44  ? -12.31191 -11.24773 13.86331  1.000 74.24353  ? 42  LYS L N   1 
ATOM   1937 C CA  . LYS B 2 44  ? -12.10835 -11.69363 12.49439  1.000 62.08558  ? 42  LYS L CA  1 
ATOM   1938 C C   . LYS B 2 44  ? -10.66111 -12.12230 12.29833  1.000 59.43293  ? 42  LYS L C   1 
ATOM   1939 O O   . LYS B 2 44  ? -9.76820  -11.76356 13.07242  1.000 66.42688  ? 42  LYS L O   1 
ATOM   1940 C CB  . LYS B 2 44  ? -12.47247 -10.59659 11.48307  1.000 65.37330  ? 42  LYS L CB  1 
ATOM   1941 C CG  . LYS B 2 44  ? -13.94731 -10.22199 11.45472  1.000 72.95088  ? 42  LYS L CG  1 
ATOM   1942 C CD  . LYS B 2 44  ? -14.80941 -11.34032 10.88337  1.000 87.03453  ? 42  LYS L CD  1 
ATOM   1943 C CE  . LYS B 2 44  ? -16.26909 -10.90338 10.74583  1.000 93.56312  ? 42  LYS L CE  1 
ATOM   1944 N NZ  . LYS B 2 44  ? -17.14347 -11.97745 10.18352  1.000 83.29314  ? 42  LYS L NZ  1 
ATOM   1945 N N   . ALA B 2 45  ? -10.44376 -12.91594 11.25768  1.000 47.97752  ? 43  ALA L N   1 
ATOM   1946 C CA  . ALA B 2 45  ? -9.09698  -13.31967 10.90993  1.000 55.42416  ? 43  ALA L CA  1 
ATOM   1947 C C   . ALA B 2 45  ? -8.34968  -12.14387 10.28290  1.000 55.15585  ? 43  ALA L C   1 
ATOM   1948 O O   . ALA B 2 45  ? -8.96527  -11.22550 9.74055   1.000 61.05968  ? 43  ALA L O   1 
ATOM   1949 C CB  . ALA B 2 45  ? -9.12702  -14.50643 9.94960   1.000 52.55168  ? 43  ALA L CB  1 
ATOM   1950 N N   . PRO B 2 46  ? -7.02460  -12.13168 10.36477  1.000 47.55078  ? 44  PRO L N   1 
ATOM   1951 C CA  . PRO B 2 46  ? -6.27763  -11.05124 9.72468   1.000 52.22994  ? 44  PRO L CA  1 
ATOM   1952 C C   . PRO B 2 46  ? -6.50103  -11.06515 8.22001   1.000 56.88302  ? 44  PRO L C   1 
ATOM   1953 O O   . PRO B 2 46  ? -6.73460  -12.10951 7.61036   1.000 59.93642  ? 44  PRO L O   1 
ATOM   1954 C CB  . PRO B 2 46  ? -4.82094  -11.35947 10.09001  1.000 50.89080  ? 44  PRO L CB  1 
ATOM   1955 C CG  . PRO B 2 46  ? -4.92230  -12.22108 11.30462  1.000 56.47775  ? 44  PRO L CG  1 
ATOM   1956 C CD  . PRO B 2 46  ? -6.13581  -13.05850 11.07527  1.000 38.63400  ? 44  PRO L CD  1 
ATOM   1957 N N   . LYS B 2 47  ? -6.45624  -9.87613  7.63047   1.000 58.75793  ? 45  LYS L N   1 
ATOM   1958 C CA  . LYS B 2 47  ? -6.66708  -9.67367  6.20497   1.000 52.61575  ? 45  LYS L CA  1 
ATOM   1959 C C   . LYS B 2 47  ? -5.48434  -8.88503  5.66403   1.000 54.55522  ? 45  LYS L C   1 
ATOM   1960 O O   . LYS B 2 47  ? -5.09090  -7.87624  6.25701   1.000 62.05029  ? 45  LYS L O   1 
ATOM   1961 C CB  . LYS B 2 47  ? -7.97901  -8.92525  5.95831   1.000 51.54724  ? 45  LYS L CB  1 
ATOM   1962 C CG  . LYS B 2 47  ? -8.23320  -8.54580  4.52006   1.000 71.35493  ? 45  LYS L CG  1 
ATOM   1963 C CD  . LYS B 2 47  ? -9.47291  -7.67319  4.41650   1.000 74.69971  ? 45  LYS L CD  1 
ATOM   1964 C CE  . LYS B 2 47  ? -9.68818  -7.17479  2.99839   1.000 69.69044  ? 45  LYS L CE  1 
ATOM   1965 N NZ  . LYS B 2 47  ? -10.84390 -6.24224  2.92737   1.000 74.61867  ? 45  LYS L NZ  1 
ATOM   1966 N N   . ARG B 2 48  ? -4.89721  -9.34928  4.56501   1.000 51.01130  ? 46  ARG L N   1 
ATOM   1967 C CA  . ARG B 2 48  ? -3.75361  -8.64919  3.99882   1.000 50.69362  ? 46  ARG L CA  1 
ATOM   1968 C C   . ARG B 2 48  ? -4.21622  -7.50313  3.11126   1.000 53.12707  ? 46  ARG L C   1 
ATOM   1969 O O   . ARG B 2 48  ? -5.18905  -7.62767  2.36103   1.000 59.10638  ? 46  ARG L O   1 
ATOM   1970 C CB  . ARG B 2 48  ? -2.86109  -9.59599  3.19962   1.000 46.20272  ? 46  ARG L CB  1 
ATOM   1971 C CG  . ARG B 2 48  ? -1.55125  -8.95388  2.79506   1.000 47.96225  ? 46  ARG L CG  1 
ATOM   1972 C CD  . ARG B 2 48  ? -0.71145  -9.89030  1.96800   1.000 49.97736  ? 46  ARG L CD  1 
ATOM   1973 N NE  . ARG B 2 48  ? -1.39282  -10.25229 0.73620   1.000 59.68057  ? 46  ARG L NE  1 
ATOM   1974 C CZ  . ARG B 2 48  ? -0.79681  -10.78932 -0.31866  1.000 64.00062  ? 46  ARG L CZ  1 
ATOM   1975 N NH1 . ARG B 2 48  ? 0.49612   -11.06458 -0.31487  1.000 64.81660  ? 46  ARG L NH1 1 
ATOM   1976 N NH2 . ARG B 2 48  ? -1.51755  -11.06002 -1.40389  1.000 66.41169  ? 46  ARG L NH2 1 
ATOM   1977 N N   . LEU B 2 49  ? -3.51348  -6.37798  3.20994   1.000 61.00795  ? 47  LEU L N   1 
ATOM   1978 C CA  . LEU B 2 49  ? -3.79696  -5.20604  2.39389   1.000 61.37692  ? 47  LEU L CA  1 
ATOM   1979 C C   . LEU B 2 49  ? -2.63369  -4.83958  1.48969   1.000 66.93473  ? 47  LEU L C   1 
ATOM   1980 O O   . LEU B 2 49  ? -2.83015  -4.63569  0.28630   1.000 76.54891  ? 47  LEU L O   1 
ATOM   1981 C CB  . LEU B 2 49  ? -4.15772  -4.01606  3.29509   1.000 59.54481  ? 47  LEU L CB  1 
ATOM   1982 C CG  . LEU B 2 49  ? -5.34106  -4.23970  4.23974   1.000 60.20895  ? 47  LEU L CG  1 
ATOM   1983 C CD1 . LEU B 2 49  ? -5.57787  -3.00339  5.08258   1.000 66.78298  ? 47  LEU L CD1 1 
ATOM   1984 C CD2 . LEU B 2 49  ? -6.60213  -4.62123  3.46736   1.000 53.76224  ? 47  LEU L CD2 1 
ATOM   1985 N N   . ILE B 2 50  ? -1.42440  -4.76347  2.03786   1.000 62.76722  ? 48  ILE L N   1 
ATOM   1986 C CA  . ILE B 2 50  ? -0.22422  -4.37845  1.30665   1.000 62.97412  ? 48  ILE L CA  1 
ATOM   1987 C C   . ILE B 2 50  ? 0.78423   -5.51377  1.41524   1.000 70.90529  ? 48  ILE L C   1 
ATOM   1988 O O   . ILE B 2 50  ? 0.99723   -6.05782  2.50529   1.000 69.90105  ? 48  ILE L O   1 
ATOM   1989 C CB  . ILE B 2 50  ? 0.37189   -3.07027  1.85978   1.000 64.12857  ? 48  ILE L CB  1 
ATOM   1990 C CG1 . ILE B 2 50  ? -0.62448  -1.93086  1.70322   1.000 64.01216  ? 48  ILE L CG1 1 
ATOM   1991 C CG2 . ILE B 2 50  ? 1.66764   -2.72562  1.16331   1.000 64.74475  ? 48  ILE L CG2 1 
ATOM   1992 C CD1 . ILE B 2 50  ? -0.96764  -1.64541  0.28059   1.000 66.22790  ? 48  ILE L CD1 1 
ATOM   1993 N N   . TYR B 2 51  ? 1.39262   -5.87651  0.28755   1.000 71.49037  ? 49  TYR L N   1 
ATOM   1994 C CA  . TYR B 2 51  ? 2.52809   -6.78720  0.26345   1.000 69.28283  ? 49  TYR L CA  1 
ATOM   1995 C C   . TYR B 2 51  ? 3.66899   -6.11576  -0.48724  1.000 69.70195  ? 49  TYR L C   1 
ATOM   1996 O O   . TYR B 2 51  ? 3.45774   -5.18087  -1.26322  1.000 73.86537  ? 49  TYR L O   1 
ATOM   1997 C CB  . TYR B 2 51  ? 2.17615   -8.14561  -0.38052  1.000 66.78467  ? 49  TYR L CB  1 
ATOM   1998 C CG  . TYR B 2 51  ? 1.83665   -8.11170  -1.86393  1.000 65.91901  ? 49  TYR L CG  1 
ATOM   1999 C CD1 . TYR B 2 51  ? 0.53857   -7.86249  -2.29866  1.000 66.09184  ? 49  TYR L CD1 1 
ATOM   2000 C CD2 . TYR B 2 51  ? 2.81246   -8.35967  -2.82747  1.000 73.85225  ? 49  TYR L CD2 1 
ATOM   2001 C CE1 . TYR B 2 51  ? 0.22526   -7.84217  -3.65161  1.000 71.02861  ? 49  TYR L CE1 1 
ATOM   2002 C CE2 . TYR B 2 51  ? 2.51183   -8.33986  -4.18049  1.000 63.87658  ? 49  TYR L CE2 1 
ATOM   2003 C CZ  . TYR B 2 51  ? 1.21851   -8.08314  -4.58666  1.000 76.13223  ? 49  TYR L CZ  1 
ATOM   2004 O OH  . TYR B 2 51  ? 0.91859   -8.06512  -5.92847  1.000 65.48984  ? 49  TYR L OH  1 
ATOM   2005 N N   . ALA B 2 52  ? 4.88593   -6.58989  -0.23242  1.000 66.23993  ? 50  ALA L N   1 
ATOM   2006 C CA  . ALA B 2 52  ? 6.08224   -6.05913  -0.87826  1.000 67.46988  ? 50  ALA L CA  1 
ATOM   2007 C C   . ALA B 2 52  ? 6.14827   -4.54031  -0.73615  1.000 69.03785  ? 50  ALA L C   1 
ATOM   2008 O O   . ALA B 2 52  ? 6.20379   -3.79617  -1.71854  1.000 75.04162  ? 50  ALA L O   1 
ATOM   2009 C CB  . ALA B 2 52  ? 6.14060   -6.48044  -2.34744  1.000 69.06443  ? 50  ALA L CB  1 
ATOM   2010 N N   . ILE B 2 53  ? 6.10115   -4.08781  0.51513   1.000 61.09866  ? 51  ILE L N   1 
ATOM   2011 C CA  . ILE B 2 53  ? 6.20682   -2.68244  0.90385   1.000 60.09010  ? 51  ILE L CA  1 
ATOM   2012 C C   . ILE B 2 53  ? 5.06239   -1.83373  0.35759   1.000 73.96053  ? 51  ILE L C   1 
ATOM   2013 O O   . ILE B 2 53  ? 4.37840   -1.14674  1.12611   1.000 73.10282  ? 51  ILE L O   1 
ATOM   2014 C CB  . ILE B 2 53  ? 7.55663   -2.07960  0.48540   1.000 68.23437  ? 51  ILE L CB  1 
ATOM   2015 C CG1 . ILE B 2 53  ? 8.70544   -2.88697  1.07642   1.000 69.79358  ? 51  ILE L CG1 1 
ATOM   2016 C CG2 . ILE B 2 53  ? 7.63816   -0.63966  0.94643   1.000 66.75040  ? 51  ILE L CG2 1 
ATOM   2017 C CD1 . ILE B 2 53  ? 10.05494  -2.33794  0.71604   1.000 71.98319  ? 51  ILE L CD1 1 
ATOM   2018 N N   . ALA B 2 54  ? 4.85482   -1.84568  -0.96683  1.000 70.26583  ? 52  ALA L N   1 
ATOM   2019 C CA  . ALA B 2 54  ? 3.93088   -0.90427  -1.59168  1.000 63.36696  ? 52  ALA L CA  1 
ATOM   2020 C C   . ALA B 2 54  ? 2.90264   -1.52132  -2.52694  1.000 69.42370  ? 52  ALA L C   1 
ATOM   2021 O O   . ALA B 2 54  ? 1.96896   -0.81388  -2.92254  1.000 68.23668  ? 52  ALA L O   1 
ATOM   2022 C CB  . ALA B 2 54  ? 4.70231   0.17206   -2.36975  1.000 61.02226  ? 52  ALA L CB  1 
ATOM   2023 N N   . SER B 2 55  ? 3.02970   -2.79427  -2.89348  1.000 76.31687  ? 53  SER L N   1 
ATOM   2024 C CA  . SER B 2 55  ? 2.09572   -3.39815  -3.84013  1.000 66.71316  ? 53  SER L CA  1 
ATOM   2025 C C   . SER B 2 55  ? 0.72116   -3.54537  -3.20152  1.000 69.78454  ? 53  SER L C   1 
ATOM   2026 O O   . SER B 2 55  ? 0.55503   -4.28849  -2.23030  1.000 81.26919  ? 53  SER L O   1 
ATOM   2027 C CB  . SER B 2 55  ? 2.60808   -4.75882  -4.30827  1.000 62.77747  ? 53  SER L CB  1 
ATOM   2028 O OG  . SER B 2 55  ? 3.87372   -4.64410  -4.93686  1.000 79.06539  ? 53  SER L OG  1 
ATOM   2029 N N   . LEU B 2 56  ? -0.26203  -2.84314  -3.74766  1.000 73.39381  ? 54  LEU L N   1 
ATOM   2030 C CA  . LEU B 2 56  ? -1.62801  -2.91773  -3.24936  1.000 69.05731  ? 54  LEU L CA  1 
ATOM   2031 C C   . LEU B 2 56  ? -2.31163  -4.15565  -3.82253  1.000 75.18792  ? 54  LEU L C   1 
ATOM   2032 O O   . LEU B 2 56  ? -2.39093  -4.31714  -5.04467  1.000 83.86742  ? 54  LEU L O   1 
ATOM   2033 C CB  . LEU B 2 56  ? -2.38843  -1.65290  -3.63390  1.000 68.05351  ? 54  LEU L CB  1 
ATOM   2034 C CG  . LEU B 2 56  ? -3.82760  -1.56280  -3.15005  1.000 74.36757  ? 54  LEU L CG  1 
ATOM   2035 C CD1 . LEU B 2 56  ? -3.84142  -1.13969  -1.70570  1.000 77.22909  ? 54  LEU L CD1 1 
ATOM   2036 C CD2 . LEU B 2 56  ? -4.60843  -0.58806  -4.01045  1.000 81.00854  ? 54  LEU L CD2 1 
ATOM   2037 N N   . TYR B 2 57  ? -2.80260  -5.02712  -2.94556  1.000 79.73220  ? 55  TYR L N   1 
ATOM   2038 C CA  . TYR B 2 57  ? -3.48120  -6.23952  -3.38277  1.000 67.19476  ? 55  TYR L CA  1 
ATOM   2039 C C   . TYR B 2 57  ? -4.76975  -5.89191  -4.12340  1.000 77.59179  ? 55  TYR L C   1 
ATOM   2040 O O   . TYR B 2 57  ? -5.43681  -4.89735  -3.82778  1.000 78.92838  ? 55  TYR L O   1 
ATOM   2041 C CB  . TYR B 2 57  ? -3.78321  -7.14553  -2.18180  1.000 68.36654  ? 55  TYR L CB  1 
ATOM   2042 C CG  . TYR B 2 57  ? -4.42293  -8.47791  -2.52882  1.000 72.93797  ? 55  TYR L CG  1 
ATOM   2043 C CD1 . TYR B 2 57  ? -3.70079  -9.46666  -3.19506  1.000 74.09001  ? 55  TYR L CD1 1 
ATOM   2044 C CD2 . TYR B 2 57  ? -5.74198  -8.75543  -2.17260  1.000 69.45016  ? 55  TYR L CD2 1 
ATOM   2045 C CE1 . TYR B 2 57  ? -4.27839  -10.69116 -3.50998  1.000 74.91829  ? 55  TYR L CE1 1 
ATOM   2046 C CE2 . TYR B 2 57  ? -6.33052  -9.97714  -2.48401  1.000 67.67938  ? 55  TYR L CE2 1 
ATOM   2047 C CZ  . TYR B 2 57  ? -5.59438  -10.93940 -3.15244  1.000 76.14099  ? 55  TYR L CZ  1 
ATOM   2048 O OH  . TYR B 2 57  ? -6.17443  -12.15157 -3.46098  1.000 65.61569  ? 55  TYR L OH  1 
ATOM   2049 N N   . SER B 2 58  ? -5.11257  -6.72399  -5.10208  1.000 73.67522  ? 56  SER L N   1 
ATOM   2050 C CA  . SER B 2 58  ? -6.29876  -6.48329  -5.91037  1.000 74.11302  ? 56  SER L CA  1 
ATOM   2051 C C   . SER B 2 58  ? -7.55734  -6.64622  -5.06681  1.000 80.42787  ? 56  SER L C   1 
ATOM   2052 O O   . SER B 2 58  ? -7.74962  -7.66917  -4.40373  1.000 81.65008  ? 56  SER L O   1 
ATOM   2053 C CB  . SER B 2 58  ? -6.32579  -7.43570  -7.09994  1.000 72.31397  ? 56  SER L CB  1 
ATOM   2054 O OG  . SER B 2 58  ? -6.22810  -8.77924  -6.66808  1.000 86.94078  ? 56  SER L OG  1 
ATOM   2055 N N   . GLY B 2 59  ? -8.42277  -5.63757  -5.10553  1.000 76.30021  ? 57  GLY L N   1 
ATOM   2056 C CA  . GLY B 2 59  ? -9.59341  -5.57429  -4.26756  1.000 67.54322  ? 57  GLY L CA  1 
ATOM   2057 C C   . GLY B 2 59  ? -9.45375  -4.62734  -3.09778  1.000 69.04587  ? 57  GLY L C   1 
ATOM   2058 O O   . GLY B 2 59  ? -10.46370 -4.24644  -2.49628  1.000 73.11082  ? 57  GLY L O   1 
ATOM   2059 N N   . VAL B 2 60  ? -8.23375  -4.23770  -2.76628  1.000 70.27594  ? 58  VAL L N   1 
ATOM   2060 C CA  . VAL B 2 60  ? -8.01175  -3.32098  -1.64847  1.000 82.79360  ? 58  VAL L CA  1 
ATOM   2061 C C   . VAL B 2 60  ? -8.22143  -1.89116  -2.14267  1.000 79.98812  ? 58  VAL L C   1 
ATOM   2062 O O   . VAL B 2 60  ? -7.71954  -1.54144  -3.22417  1.000 75.27419  ? 58  VAL L O   1 
ATOM   2063 C CB  . VAL B 2 60  ? -6.61029  -3.50458  -1.06776  1.000 78.16210  ? 58  VAL L CB  1 
ATOM   2064 C CG1 . VAL B 2 60  ? -6.42104  -2.62442  0.15896   1.000 73.66879  ? 58  VAL L CG1 1 
ATOM   2065 C CG2 . VAL B 2 60  ? -6.37227  -4.96266  -0.71250  1.000 70.33485  ? 58  VAL L CG2 1 
ATOM   2066 N N   . PRO B 2 61  ? -8.97648  -1.06624  -1.41383  1.000 79.47652  ? 59  PRO L N   1 
ATOM   2067 C CA  . PRO B 2 61  ? -9.13375  0.34097   -1.80682  1.000 79.55902  ? 59  PRO L CA  1 
ATOM   2068 C C   . PRO B 2 61  ? -7.79317  1.05779   -1.89449  1.000 80.86215  ? 59  PRO L C   1 
ATOM   2069 O O   . PRO B 2 61  ? -6.89417  0.84027   -1.07787  1.000 80.60300  ? 59  PRO L O   1 
ATOM   2070 C CB  . PRO B 2 61  ? -10.01527 0.91680   -0.69302  1.000 70.14671  ? 59  PRO L CB  1 
ATOM   2071 C CG  . PRO B 2 61  ? -10.84287 -0.25613  -0.24804  1.000 62.88044  ? 59  PRO L CG  1 
ATOM   2072 C CD  . PRO B 2 61  ? -9.92990  -1.45741  -0.35919  1.000 76.56688  ? 59  PRO L CD  1 
ATOM   2073 N N   . SER B 2 62  ? -7.66801  1.92262   -2.90607  1.000 71.92714  ? 60  SER L N   1 
ATOM   2074 C CA  . SER B 2 62  ? -6.39900  2.58203   -3.20038  1.000 75.42189  ? 60  SER L CA  1 
ATOM   2075 C C   . SER B 2 62  ? -6.01401  3.63418   -2.16701  1.000 71.05378  ? 60  SER L C   1 
ATOM   2076 O O   . SER B 2 62  ? -4.91927  4.20325   -2.26694  1.000 54.69436  ? 60  SER L O   1 
ATOM   2077 C CB  . SER B 2 62  ? -6.45702  3.21113   -4.59481  1.000 72.43907  ? 60  SER L CB  1 
ATOM   2078 O OG  . SER B 2 62  ? -7.66865  3.92586   -4.78353  1.000 81.55773  ? 60  SER L OG  1 
ATOM   2079 N N   . ARG B 2 63  ? -6.88430  3.91360   -1.19061  1.000 82.32854  ? 61  ARG L N   1 
ATOM   2080 C CA  . ARG B 2 63  ? -6.52744  4.82418   -0.10890  1.000 79.59861  ? 61  ARG L CA  1 
ATOM   2081 C C   . ARG B 2 63  ? -5.41208  4.26152   0.76049   1.000 80.94217  ? 61  ARG L C   1 
ATOM   2082 O O   . ARG B 2 63  ? -4.69901  5.03043   1.41796   1.000 75.85883  ? 61  ARG L O   1 
ATOM   2083 C CB  . ARG B 2 63  ? -7.76254  5.14389   0.74185   1.000 77.18133  ? 61  ARG L CB  1 
ATOM   2084 C CG  . ARG B 2 63  ? -8.58085  3.93728   1.20163   1.000 66.71410  ? 61  ARG L CG  1 
ATOM   2085 C CD  . ARG B 2 63  ? -9.78331  4.38460   2.04719   1.000 74.09191  ? 61  ARG L CD  1 
ATOM   2086 N NE  . ARG B 2 63  ? -10.51957 3.26703   2.62768   1.000 71.57774  ? 61  ARG L NE  1 
ATOM   2087 C CZ  . ARG B 2 63  ? -11.55503 2.66798   2.05287   1.000 83.05482  ? 61  ARG L CZ  1 
ATOM   2088 N NH1 . ARG B 2 63  ? -12.01802 3.06287   0.87975   1.000 84.91346  ? 61  ARG L NH1 1 
ATOM   2089 N NH2 . ARG B 2 63  ? -12.14217 1.64678   2.67135   1.000 79.83821  ? 61  ARG L NH2 1 
ATOM   2090 N N   . PHE B 2 64  ? -5.24837  2.94097   0.76933   1.000 81.32834  ? 62  PHE L N   1 
ATOM   2091 C CA  . PHE B 2 64  ? -4.15070  2.29565   1.47477   1.000 76.24355  ? 62  PHE L CA  1 
ATOM   2092 C C   . PHE B 2 64  ? -2.91372  2.32669   0.58886   1.000 67.87639  ? 62  PHE L C   1 
ATOM   2093 O O   . PHE B 2 64  ? -2.92144  1.77526   -0.51680  1.000 70.99880  ? 62  PHE L O   1 
ATOM   2094 C CB  . PHE B 2 64  ? -4.51883  0.85771   1.83653   1.000 77.87014  ? 62  PHE L CB  1 
ATOM   2095 C CG  . PHE B 2 64  ? -5.71010  0.73997   2.75635   1.000 73.92621  ? 62  PHE L CG  1 
ATOM   2096 C CD1 . PHE B 2 64  ? -5.55072  0.82588   4.13276   1.000 63.48606  ? 62  PHE L CD1 1 
ATOM   2097 C CD2 . PHE B 2 64  ? -6.98524  0.52505   2.24657   1.000 69.66449  ? 62  PHE L CD2 1 
ATOM   2098 C CE1 . PHE B 2 64  ? -6.63924  0.70711   4.98319   1.000 70.48425  ? 62  PHE L CE1 1 
ATOM   2099 C CE2 . PHE B 2 64  ? -8.07839  0.40819   3.09473   1.000 73.98819  ? 62  PHE L CE2 1 
ATOM   2100 C CZ  . PHE B 2 64  ? -7.90517  0.49726   4.46511   1.000 63.93990  ? 62  PHE L CZ  1 
ATOM   2101 N N   . SER B 2 65  ? -1.85661  2.97393   1.06713   1.000 69.21372  ? 63  SER L N   1 
ATOM   2102 C CA  . SER B 2 65  ? -0.62438  3.11510   0.30839   1.000 66.57287  ? 63  SER L CA  1 
ATOM   2103 C C   . SER B 2 65  ? 0.55312   2.72394   1.18666   1.000 71.30446  ? 63  SER L C   1 
ATOM   2104 O O   . SER B 2 65  ? 0.68935   3.22148   2.30921   1.000 73.68622  ? 63  SER L O   1 
ATOM   2105 C CB  . SER B 2 65  ? -0.45935  4.54786   -0.21056  1.000 69.46392  ? 63  SER L CB  1 
ATOM   2106 O OG  . SER B 2 65  ? -0.38734  5.47461   0.85607   1.000 70.67811  ? 63  SER L OG  1 
ATOM   2107 N N   . GLY B 2 66  ? 1.39590   1.83410   0.67441   1.000 67.74791  ? 64  GLY L N   1 
ATOM   2108 C CA  . GLY B 2 66  ? 2.56902   1.37003   1.39314   1.000 67.18818  ? 64  GLY L CA  1 
ATOM   2109 C C   . GLY B 2 66  ? 3.81548   2.09640   0.92532   1.000 72.22106  ? 64  GLY L C   1 
ATOM   2110 O O   . GLY B 2 66  ? 3.97380   2.38258   -0.26189  1.000 73.92984  ? 64  GLY L O   1 
ATOM   2111 N N   . SER B 2 67  ? 4.70405   2.38955   1.87315   1.000 64.43454  ? 65  SER L N   1 
ATOM   2112 C CA  . SER B 2 67  ? 5.87905   3.20436   1.60648   1.000 70.38168  ? 65  SER L CA  1 
ATOM   2113 C C   . SER B 2 67  ? 7.08432   2.60987   2.31880   1.000 81.19359  ? 65  SER L C   1 
ATOM   2114 O O   . SER B 2 67  ? 6.95892   2.06667   3.41851   1.000 74.12503  ? 65  SER L O   1 
ATOM   2115 C CB  . SER B 2 67  ? 5.65048   4.66564   2.04250   1.000 81.53053  ? 65  SER L CB  1 
ATOM   2116 O OG  . SER B 2 67  ? 4.88418   4.74634   3.23361   1.000 81.51119  ? 65  SER L OG  1 
ATOM   2117 N N   . GLY B 2 68  ? 8.26264   2.73091   1.68619   1.000 78.24783  ? 66  GLY L N   1 
ATOM   2118 C CA  . GLY B 2 68  ? 9.45528   2.07152   2.16948   1.000 83.72644  ? 66  GLY L CA  1 
ATOM   2119 C C   . GLY B 2 68  ? 10.60526  3.03105   2.42202   1.000 89.29806  ? 66  GLY L C   1 
ATOM   2120 O O   . GLY B 2 68  ? 10.64608  4.14545   1.89973   1.000 87.10552  ? 66  GLY L O   1 
ATOM   2121 N N   . SER B 2 69  ? 11.55527  2.56437   3.25111   1.000 90.19780  ? 67  SER L N   1 
ATOM   2122 C CA  . SER B 2 69  ? 12.80456  3.31116   3.41467   1.000 87.07373  ? 67  SER L CA  1 
ATOM   2123 C C   . SER B 2 69  ? 13.97201  2.43203   3.84703   1.000 98.04156  ? 67  SER L C   1 
ATOM   2124 O O   . SER B 2 69  ? 14.85643  2.94515   4.54042   1.000 95.58767  ? 67  SER L O   1 
ATOM   2125 C CB  . SER B 2 69  ? 12.63035  4.43918   4.43147   1.000 91.60762  ? 67  SER L CB  1 
ATOM   2126 O OG  . SER B 2 69  ? 12.65617  3.93085   5.75637   1.000 102.54615 ? 67  SER L OG  1 
ATOM   2127 N N   . GLY B 2 70  ? 14.00937  1.15929   3.49641   1.000 101.99636 ? 68  GLY L N   1 
ATOM   2128 C CA  . GLY B 2 70  ? 15.07513  0.27013   3.94621   1.000 109.47698 ? 68  GLY L CA  1 
ATOM   2129 C C   . GLY B 2 70  ? 14.79453  -0.44141  5.25475   1.000 114.32114 ? 68  GLY L C   1 
ATOM   2130 O O   . GLY B 2 70  ? 14.85608  -1.67035  5.31828   1.000 109.96646 ? 68  GLY L O   1 
ATOM   2131 N N   . THR B 2 71  ? 14.47632  0.32776   6.30452   1.000 115.25485 ? 69  THR L N   1 
ATOM   2132 C CA  . THR B 2 71  ? 14.18111  -0.17997  7.64292   1.000 115.88324 ? 69  THR L CA  1 
ATOM   2133 C C   . THR B 2 71  ? 12.84656  0.29817   8.19678   1.000 110.53269 ? 69  THR L C   1 
ATOM   2134 O O   . THR B 2 71  ? 12.16552  -0.46520  8.88585   1.000 103.46819 ? 69  THR L O   1 
ATOM   2135 C CB  . THR B 2 71  ? 15.29788  0.21756   8.62449   1.000 104.29543 ? 69  THR L CB  1 
ATOM   2136 O OG1 . THR B 2 71  ? 15.52981  1.62869   8.53645   1.000 101.47469 ? 69  THR L OG1 1 
ATOM   2137 C CG2 . THR B 2 71  ? 16.59004  -0.53722  8.31459   1.000 100.81622 ? 69  THR L CG2 1 
ATOM   2138 N N   . ASP B 2 72  ? 12.44738  1.53937   7.91938   1.000 111.53571 ? 70  ASP L N   1 
ATOM   2139 C CA  . ASP B 2 72  ? 11.20741  2.10201   8.44818   1.000 96.65808  ? 70  ASP L CA  1 
ATOM   2140 C C   . ASP B 2 72  ? 10.13798  2.05877   7.36166   1.000 92.52161  ? 70  ASP L C   1 
ATOM   2141 O O   . ASP B 2 72  ? 10.22030  2.78841   6.36925   1.000 94.08884  ? 70  ASP L O   1 
ATOM   2142 C CB  . ASP B 2 72  ? 11.42512  3.52750   8.95295   1.000 97.09802  ? 70  ASP L CB  1 
ATOM   2143 C CG  . ASP B 2 72  ? 12.46876  3.60360   10.05502  1.000 112.61544 ? 70  ASP L CG  1 
ATOM   2144 O OD1 . ASP B 2 72  ? 13.24680  2.63742   10.21192  1.000 106.52202 ? 70  ASP L OD1 1 
ATOM   2145 O OD2 . ASP B 2 72  ? 12.50739  4.63034   10.76835  1.000 118.34089 ? 70  ASP L OD2 1 
ATOM   2146 N N   . PHE B 2 73  ? 9.13172   1.21302   7.56059   1.000 89.74359  ? 71  PHE L N   1 
ATOM   2147 C CA  . PHE B 2 73  ? 8.03144   1.04303   6.62225   1.000 79.58157  ? 71  PHE L CA  1 
ATOM   2148 C C   . PHE B 2 73  ? 6.78806   1.74651   7.15574   1.000 84.27770  ? 71  PHE L C   1 
ATOM   2149 O O   . PHE B 2 73  ? 6.50456   1.70192   8.35727   1.000 85.10858  ? 71  PHE L O   1 
ATOM   2150 C CB  . PHE B 2 73  ? 7.75297   -0.44481  6.39645   1.000 74.37184  ? 71  PHE L CB  1 
ATOM   2151 C CG  . PHE B 2 73  ? 8.97359   -1.23541  6.00966   1.000 86.82540  ? 71  PHE L CG  1 
ATOM   2152 C CD1 . PHE B 2 73  ? 9.84416   -1.71172  6.97954   1.000 85.77798  ? 71  PHE L CD1 1 
ATOM   2153 C CD2 . PHE B 2 73  ? 9.25325   -1.49827  4.67521   1.000 84.35060  ? 71  PHE L CD2 1 
ATOM   2154 C CE1 . PHE B 2 73  ? 10.97152  -2.43331  6.62860   1.000 93.09795  ? 71  PHE L CE1 1 
ATOM   2155 C CE2 . PHE B 2 73  ? 10.37957  -2.22213  4.31444   1.000 86.34804  ? 71  PHE L CE2 1 
ATOM   2156 C CZ  . PHE B 2 73  ? 11.24202  -2.68878  5.29332   1.000 92.93200  ? 71  PHE L CZ  1 
ATOM   2157 N N   . THR B 2 74  ? 6.04516   2.39857   6.26286   1.000 76.84225  ? 72  THR L N   1 
ATOM   2158 C CA  . THR B 2 74  ? 4.93482   3.24993   6.67240   1.000 69.87419  ? 72  THR L CA  1 
ATOM   2159 C C   . THR B 2 74  ? 3.67084   2.88938   5.91104   1.000 73.20901  ? 72  THR L C   1 
ATOM   2160 O O   . THR B 2 74  ? 3.67816   2.83026   4.67745   1.000 79.63448  ? 72  THR L O   1 
ATOM   2161 C CB  . THR B 2 74  ? 5.26385   4.73039   6.45445   1.000 75.25906  ? 72  THR L CB  1 
ATOM   2162 O OG1 . THR B 2 74  ? 6.23573   5.14747   7.41803   1.000 84.81843  ? 72  THR L OG1 1 
ATOM   2163 C CG2 . THR B 2 74  ? 4.01845   5.58848   6.60037   1.000 75.37872  ? 72  THR L CG2 1 
ATOM   2164 N N   . LEU B 2 75  ? 2.58847   2.66294   6.65067   1.000 77.31124  ? 73  LEU L N   1 
ATOM   2165 C CA  . LEU B 2 75  ? 1.26191   2.47971   6.07868   1.000 76.05918  ? 73  LEU L CA  1 
ATOM   2166 C C   . LEU B 2 75  ? 0.52400   3.80894   6.12736   1.000 75.93141  ? 73  LEU L C   1 
ATOM   2167 O O   . LEU B 2 75  ? 0.53514   4.49366   7.15572   1.000 80.98635  ? 73  LEU L O   1 
ATOM   2168 C CB  . LEU B 2 75  ? 0.47679   1.40897   6.83679   1.000 61.31849  ? 73  LEU L CB  1 
ATOM   2169 C CG  . LEU B 2 75  ? -0.91011  1.08408   6.28380   1.000 73.52704  ? 73  LEU L CG  1 
ATOM   2170 C CD1 . LEU B 2 75  ? -0.82956  0.62277   4.83264   1.000 72.97339  ? 73  LEU L CD1 1 
ATOM   2171 C CD2 . LEU B 2 75  ? -1.57830  0.03205   7.14547   1.000 65.11615  ? 73  LEU L CD2 1 
ATOM   2172 N N   . THR B 2 76  ? -0.10431  4.17998   5.01771   1.000 74.42160  ? 74  THR L N   1 
ATOM   2173 C CA  . THR B 2 76  ? -0.79041  5.46075   4.92414   1.000 79.88431  ? 74  THR L CA  1 
ATOM   2174 C C   . THR B 2 76  ? -2.19327  5.24695   4.37970   1.000 76.98499  ? 74  THR L C   1 
ATOM   2175 O O   . THR B 2 76  ? -2.36715  4.69137   3.28899   1.000 74.55345  ? 74  THR L O   1 
ATOM   2176 C CB  . THR B 2 76  ? -0.01077  6.44450   4.04831   1.000 83.43496  ? 74  THR L CB  1 
ATOM   2177 O OG1 . THR B 2 76  ? 1.23038   6.76692   4.69045   1.000 75.44062  ? 74  THR L OG1 1 
ATOM   2178 C CG2 . THR B 2 76  ? -0.81592  7.71934   3.84202   1.000 81.17329  ? 74  THR L CG2 1 
ATOM   2179 N N   . ILE B 2 77  ? -3.18638  5.67293   5.15028   1.000 77.94825  ? 75  ILE L N   1 
ATOM   2180 C CA  . ILE B 2 77  ? -4.57450  5.70274   4.71614   1.000 82.41320  ? 75  ILE L CA  1 
ATOM   2181 C C   . ILE B 2 77  ? -4.91072  7.16168   4.44629   1.000 88.90412  ? 75  ILE L C   1 
ATOM   2182 O O   . ILE B 2 77  ? -4.96419  7.97603   5.37588   1.000 96.44795  ? 75  ILE L O   1 
ATOM   2183 C CB  . ILE B 2 77  ? -5.51360  5.09130   5.76099   1.000 63.40312  ? 75  ILE L CB  1 
ATOM   2184 C CG1 . ILE B 2 77  ? -4.90534  3.80646   6.32749   1.000 70.10755  ? 75  ILE L CG1 1 
ATOM   2185 C CG2 . ILE B 2 77  ? -6.87127  4.80938   5.13981   1.000 78.94223  ? 75  ILE L CG2 1 
ATOM   2186 C CD1 . ILE B 2 77  ? -5.70162  3.19810   7.46825   1.000 54.83818  ? 75  ILE L CD1 1 
ATOM   2187 N N   . SER B 2 78  ? -5.11513  7.50294   3.17290   1.000 89.43070  ? 76  SER L N   1 
ATOM   2188 C CA  . SER B 2 78  ? -5.32628  8.90000   2.80466   1.000 83.17499  ? 76  SER L CA  1 
ATOM   2189 C C   . SER B 2 78  ? -6.62333  9.44145   3.40262   1.000 78.99753  ? 76  SER L C   1 
ATOM   2190 O O   . SER B 2 78  ? -6.60591  10.38394  4.20268   1.000 76.35972  ? 76  SER L O   1 
ATOM   2191 C CB  . SER B 2 78  ? -5.30956  9.04478   1.27905   1.000 71.89457  ? 76  SER L CB  1 
ATOM   2192 O OG  . SER B 2 78  ? -5.95291  7.95127   0.64713   1.000 65.44207  ? 76  SER L OG  1 
ATOM   2193 N N   . SER B 2 79  ? -7.76039  8.84827   3.04005   1.000 83.60989  ? 77  SER L N   1 
ATOM   2194 C CA  . SER B 2 79  ? -9.07079  9.29232   3.51219   1.000 79.35944  ? 77  SER L CA  1 
ATOM   2195 C C   . SER B 2 79  ? -9.72150  8.16201   4.29971   1.000 85.65508  ? 77  SER L C   1 
ATOM   2196 O O   . SER B 2 79  ? -10.13707 7.15234   3.71885   1.000 78.61764  ? 77  SER L O   1 
ATOM   2197 C CB  . SER B 2 79  ? -9.95781  9.72671   2.34724   1.000 70.22318  ? 77  SER L CB  1 
ATOM   2198 O OG  . SER B 2 79  ? -11.20139 10.20772  2.81974   1.000 80.27947  ? 77  SER L OG  1 
ATOM   2199 N N   . LEU B 2 80  ? -9.82541  8.34588   5.61423   1.000 77.84356  ? 78  LEU L N   1 
ATOM   2200 C CA  . LEU B 2 80  ? -10.32411 7.29800   6.49370   1.000 72.54872  ? 78  LEU L CA  1 
ATOM   2201 C C   . LEU B 2 80  ? -11.80575 7.03140   6.24859   1.000 81.04026  ? 78  LEU L C   1 
ATOM   2202 O O   . LEU B 2 80  ? -12.58803 7.95210   6.00193   1.000 89.07863  ? 78  LEU L O   1 
ATOM   2203 C CB  . LEU B 2 80  ? -10.09453 7.69746   7.94644   1.000 79.36487  ? 78  LEU L CB  1 
ATOM   2204 C CG  . LEU B 2 80  ? -9.72819  6.57883   8.91173   1.000 86.58489  ? 78  LEU L CG  1 
ATOM   2205 C CD1 . LEU B 2 80  ? -8.53627  5.80152   8.38973   1.000 68.83131  ? 78  LEU L CD1 1 
ATOM   2206 C CD2 . LEU B 2 80  ? -9.43383  7.16723   10.28338  1.000 85.45523  ? 78  LEU L CD2 1 
ATOM   2207 N N   . GLN B 2 81  ? -12.19110 5.76583   6.32750   1.000 79.25575  ? 79  GLN L N   1 
ATOM   2208 C CA  . GLN B 2 81  ? -13.54472 5.31577   6.04630   1.000 75.24140  ? 79  GLN L CA  1 
ATOM   2209 C C   . GLN B 2 81  ? -14.06774 4.49940   7.21573   1.000 83.38278  ? 79  GLN L C   1 
ATOM   2210 O O   . GLN B 2 81  ? -13.28840 4.04022   8.05712   1.000 83.93313  ? 79  GLN L O   1 
ATOM   2211 C CB  . GLN B 2 81  ? -13.58286 4.47924   4.75860   1.000 84.19375  ? 79  GLN L CB  1 
ATOM   2212 C CG  . GLN B 2 81  ? -13.14317 5.25401   3.51921   1.000 96.57970  ? 79  GLN L CG  1 
ATOM   2213 C CD  . GLN B 2 81  ? -13.98692 6.49777   3.27141   1.000 92.72937  ? 79  GLN L CD  1 
ATOM   2214 O OE1 . GLN B 2 81  ? -15.19207 6.40442   3.03710   1.000 87.45520  ? 79  GLN L OE1 1 
ATOM   2215 N NE2 . GLN B 2 81  ? -13.35571 7.66858   3.32890   1.000 85.27078  ? 79  GLN L NE2 1 
ATOM   2216 N N   . PRO B 2 82  ? -15.38939 4.30840   7.30733   1.000 90.61888  ? 80  PRO L N   1 
ATOM   2217 C CA  . PRO B 2 82  ? -15.93903 3.56609   8.45735   1.000 86.78583  ? 80  PRO L CA  1 
ATOM   2218 C C   . PRO B 2 82  ? -15.43298 2.13827   8.57157   1.000 81.54817  ? 80  PRO L C   1 
ATOM   2219 O O   . PRO B 2 82  ? -15.24174 1.64290   9.68990   1.000 86.79358  ? 80  PRO L O   1 
ATOM   2220 C CB  . PRO B 2 82  ? -17.45305 3.60550   8.20431   1.000 84.41143  ? 80  PRO L CB  1 
ATOM   2221 C CG  . PRO B 2 82  ? -17.66427 4.82244   7.38662   1.000 95.70604  ? 80  PRO L CG  1 
ATOM   2222 C CD  . PRO B 2 82  ? -16.45553 4.92193   6.49473   1.000 90.86836  ? 80  PRO L CD  1 
ATOM   2223 N N   . GLU B 2 83  ? -15.21235 1.45655   7.45381   1.000 78.44197  ? 81  GLU L N   1 
ATOM   2224 C CA  . GLU B 2 83  ? -14.71739 0.08809   7.49384   1.000 80.83794  ? 81  GLU L CA  1 
ATOM   2225 C C   . GLU B 2 83  ? -13.21277 0.00478   7.73563   1.000 74.71832  ? 81  GLU L C   1 
ATOM   2226 O O   . GLU B 2 83  ? -12.66118 -1.10110  7.72875   1.000 73.64143  ? 81  GLU L O   1 
ATOM   2227 C CB  . GLU B 2 83  ? -15.08154 -0.63625  6.19219   1.000 79.23928  ? 81  GLU L CB  1 
ATOM   2228 C CG  . GLU B 2 83  ? -14.39663 -0.09910  4.93866   1.000 80.38961  ? 81  GLU L CG  1 
ATOM   2229 C CD  . GLU B 2 83  ? -15.06162 1.14308   4.36436   1.000 89.73861  ? 81  GLU L CD  1 
ATOM   2230 O OE1 . GLU B 2 83  ? -16.00528 1.67775   4.98902   1.000 92.43575  ? 81  GLU L OE1 1 
ATOM   2231 O OE2 . GLU B 2 83  ? -14.63628 1.58165   3.27444   1.000 95.73893  ? 81  GLU L OE2 1 
ATOM   2232 N N   . ASP B 2 84  ? -12.54007 1.13230   7.95640   1.000 66.58647  ? 82  ASP L N   1 
ATOM   2233 C CA  . ASP B 2 84  ? -11.09916 1.15874   8.15002   1.000 59.56490  ? 82  ASP L CA  1 
ATOM   2234 C C   . ASP B 2 84  ? -10.69998 1.17226   9.61662   1.000 67.52238  ? 82  ASP L C   1 
ATOM   2235 O O   . ASP B 2 84  ? -9.50976  1.30610   9.92267   1.000 65.76850  ? 82  ASP L O   1 
ATOM   2236 C CB  . ASP B 2 84  ? -10.49250 2.37244   7.44503   1.000 72.05510  ? 82  ASP L CB  1 
ATOM   2237 C CG  . ASP B 2 84  ? -10.58376 2.27697   5.94232   1.000 79.35663  ? 82  ASP L CG  1 
ATOM   2238 O OD1 . ASP B 2 84  ? -10.99627 1.20675   5.44136   1.000 69.28870  ? 82  ASP L OD1 1 
ATOM   2239 O OD2 . ASP B 2 84  ? -10.24025 3.27562   5.26857   1.000 81.97028  ? 82  ASP L OD2 1 
ATOM   2240 N N   . PHE B 2 85  ? -11.65507 1.05099   10.53094  1.000 62.83130  ? 83  PHE L N   1 
ATOM   2241 C CA  . PHE B 2 85  ? -11.34303 1.09742   11.95671  1.000 67.33411  ? 83  PHE L CA  1 
ATOM   2242 C C   . PHE B 2 85  ? -11.14454 -0.32780  12.44699  1.000 63.22716  ? 83  PHE L C   1 
ATOM   2243 O O   . PHE B 2 85  ? -12.10340 -1.08612  12.61197  1.000 69.39441  ? 83  PHE L O   1 
ATOM   2244 C CB  . PHE B 2 85  ? -12.43221 1.83673   12.71979  1.000 70.53145  ? 83  PHE L CB  1 
ATOM   2245 C CG  . PHE B 2 85  ? -12.58269 3.25724   12.28357  1.000 71.71903  ? 83  PHE L CG  1 
ATOM   2246 C CD1 . PHE B 2 85  ? -11.72474 4.23243   12.75803  1.000 72.65694  ? 83  PHE L CD1 1 
ATOM   2247 C CD2 . PHE B 2 85  ? -13.54906 3.61136   11.36293  1.000 65.86134  ? 83  PHE L CD2 1 
ATOM   2248 C CE1 . PHE B 2 85  ? -11.84751 5.54000   12.34158  1.000 77.39762  ? 83  PHE L CE1 1 
ATOM   2249 C CE2 . PHE B 2 85  ? -13.67964 4.91819   10.94691  1.000 70.53197  ? 83  PHE L CE2 1 
ATOM   2250 C CZ  . PHE B 2 85  ? -12.82753 5.88311   11.43343  1.000 71.47444  ? 83  PHE L CZ  1 
ATOM   2251 N N   . ALA B 2 86  ? -9.88719  -0.68896  12.66682  1.000 53.97559  ? 84  ALA L N   1 
ATOM   2252 C CA  . ALA B 2 86  ? -9.50646  -2.02642  13.08329  1.000 54.35987  ? 84  ALA L CA  1 
ATOM   2253 C C   . ALA B 2 86  ? -8.07437  -1.94917  13.59311  1.000 56.57945  ? 84  ALA L C   1 
ATOM   2254 O O   . ALA B 2 86  ? -7.54378  -0.85953  13.83446  1.000 57.13439  ? 84  ALA L O   1 
ATOM   2255 C CB  . ALA B 2 86  ? -9.67378  -3.02890  11.93519  1.000 47.18741  ? 84  ALA L CB  1 
ATOM   2256 N N   . THR B 2 87  ? -7.45186  -3.10707  13.77235  1.000 50.92053  ? 85  THR L N   1 
ATOM   2257 C CA  . THR B 2 87  ? -6.07151  -3.18902  14.22345  1.000 61.44013  ? 85  THR L CA  1 
ATOM   2258 C C   . THR B 2 87  ? -5.18524  -3.55068  13.03705  1.000 63.37364  ? 85  THR L C   1 
ATOM   2259 O O   . THR B 2 87  ? -5.52004  -4.44534  12.25361  1.000 60.89371  ? 85  THR L O   1 
ATOM   2260 C CB  . THR B 2 87  ? -5.92567  -4.21483  15.35103  1.000 57.65858  ? 85  THR L CB  1 
ATOM   2261 O OG1 . THR B 2 87  ? -6.86772  -3.91432  16.38830  1.000 61.64183  ? 85  THR L OG1 1 
ATOM   2262 C CG2 . THR B 2 87  ? -4.52177  -4.17188  15.93436  1.000 55.01705  ? 85  THR L CG2 1 
ATOM   2263 N N   . TYR B 2 88  ? -4.07386  -2.83992  12.89089  1.000 60.74192  ? 86  TYR L N   1 
ATOM   2264 C CA  . TYR B 2 88  ? -3.16580  -3.03587  11.77088  1.000 58.10097  ? 86  TYR L CA  1 
ATOM   2265 C C   . TYR B 2 88  ? -1.84532  -3.58163  12.28676  1.000 54.62568  ? 86  TYR L C   1 
ATOM   2266 O O   . TYR B 2 88  ? -1.28726  -3.06085  13.25881  1.000 56.20395  ? 86  TYR L O   1 
ATOM   2267 C CB  . TYR B 2 88  ? -2.95881  -1.73013  10.99732  1.000 56.93084  ? 86  TYR L CB  1 
ATOM   2268 C CG  . TYR B 2 88  ? -4.22418  -1.26587  10.31076  1.000 49.51540  ? 86  TYR L CG  1 
ATOM   2269 C CD1 . TYR B 2 88  ? -5.18296  -0.53268  10.99523  1.000 48.94532  ? 86  TYR L CD1 1 
ATOM   2270 C CD2 . TYR B 2 88  ? -4.47540  -1.58848  8.98493   1.000 61.20583  ? 86  TYR L CD2 1 
ATOM   2271 C CE1 . TYR B 2 88  ? -6.35086  -0.12046  10.37198  1.000 55.25108  ? 86  TYR L CE1 1 
ATOM   2272 C CE2 . TYR B 2 88  ? -5.63829  -1.18135  8.35399   1.000 56.55099  ? 86  TYR L CE2 1 
ATOM   2273 C CZ  . TYR B 2 88  ? -6.57090  -0.44854  9.05181   1.000 52.09649  ? 86  TYR L CZ  1 
ATOM   2274 O OH  . TYR B 2 88  ? -7.72465  -0.04239  8.42330   1.000 54.50744  ? 86  TYR L OH  1 
ATOM   2275 N N   . TYR B 2 89  ? -1.36878  -4.64698  11.65448  1.000 52.43434  ? 87  TYR L N   1 
ATOM   2276 C CA  . TYR B 2 89  ? -0.09710  -5.26114  11.99920  1.000 53.97052  ? 87  TYR L CA  1 
ATOM   2277 C C   . TYR B 2 89  ? 0.81664   -5.21290  10.78351  1.000 59.97064  ? 87  TYR L C   1 
ATOM   2278 O O   . TYR B 2 89  ? 0.39290   -5.54035  9.66841   1.000 56.84202  ? 87  TYR L O   1 
ATOM   2279 C CB  . TYR B 2 89  ? -0.27548  -6.71485  12.46707  1.000 53.52668  ? 87  TYR L CB  1 
ATOM   2280 C CG  . TYR B 2 89  ? -1.08543  -6.90701  13.73808  1.000 64.81612  ? 87  TYR L CG  1 
ATOM   2281 C CD1 . TYR B 2 89  ? -0.47264  -6.89207  14.99707  1.000 60.28990  ? 87  TYR L CD1 1 
ATOM   2282 C CD2 . TYR B 2 89  ? -2.46117  -7.14011  13.67815  1.000 56.48478  ? 87  TYR L CD2 1 
ATOM   2283 C CE1 . TYR B 2 89  ? -1.21947  -7.07975  16.16115  1.000 58.45043  ? 87  TYR L CE1 1 
ATOM   2284 C CE2 . TYR B 2 89  ? -3.21130  -7.33215  14.82785  1.000 56.74547  ? 87  TYR L CE2 1 
ATOM   2285 C CZ  . TYR B 2 89  ? -2.59305  -7.30125  16.06389  1.000 67.65550  ? 87  TYR L CZ  1 
ATOM   2286 O OH  . TYR B 2 89  ? -3.36666  -7.49366  17.19117  1.000 67.93041  ? 87  TYR L OH  1 
ATOM   2287 N N   . CYS B 2 90  ? 2.05371   -4.77630  10.99762  1.000 60.62684  ? 88  CYS L N   1 
ATOM   2288 C CA  . CYS B 2 90  ? 3.10775   -4.93556  10.01159  1.000 61.33546  ? 88  CYS L CA  1 
ATOM   2289 C C   . CYS B 2 90  ? 3.83031   -6.24320  10.28257  1.000 59.10524  ? 88  CYS L C   1 
ATOM   2290 O O   . CYS B 2 90  ? 4.04657   -6.61547  11.43751  1.000 64.52900  ? 88  CYS L O   1 
ATOM   2291 C CB  . CYS B 2 90  ? 4.10299   -3.77605  10.06580  1.000 67.33385  ? 88  CYS L CB  1 
ATOM   2292 S SG  . CYS B 2 90  ? 4.81022   -3.50268  11.70471  1.000 72.55404  ? 88  CYS L SG  1 
ATOM   2293 N N   . VAL B 2 91  ? 4.19567   -6.94081  9.21517   1.000 58.88265  ? 89  VAL L N   1 
ATOM   2294 C CA  . VAL B 2 91  ? 4.95041   -8.18236  9.31670   1.000 52.99567  ? 89  VAL L CA  1 
ATOM   2295 C C   . VAL B 2 91  ? 6.05905   -8.15087  8.27180   1.000 66.78234  ? 89  VAL L C   1 
ATOM   2296 O O   . VAL B 2 91  ? 5.86197   -7.66723  7.15127   1.000 68.93196  ? 89  VAL L O   1 
ATOM   2297 C CB  . VAL B 2 91  ? 4.03644   -9.41436  9.14615   1.000 46.62505  ? 89  VAL L CB  1 
ATOM   2298 C CG1 . VAL B 2 91  ? 3.22266   -9.30473  7.86695   1.000 56.53389  ? 89  VAL L CG1 1 
ATOM   2299 C CG2 . VAL B 2 91  ? 4.84481   -10.70042 9.16676   1.000 47.29464  ? 89  VAL L CG2 1 
ATOM   2300 N N   . GLY B 2 92  ? 7.23778   -8.63183  8.65432   1.000 69.07556  ? 90  GLY L N   1 
ATOM   2301 C CA  . GLY B 2 92  ? 8.36154   -8.70179  7.74474   1.000 62.57588  ? 90  GLY L CA  1 
ATOM   2302 C C   . GLY B 2 92  ? 9.08880   -10.02647 7.84193   1.000 72.90483  ? 90  GLY L C   1 
ATOM   2303 O O   . GLY B 2 92  ? 9.22826   -10.58118 8.93637   1.000 74.22240  ? 90  GLY L O   1 
ATOM   2304 N N   . HIS B 2 93  ? 9.54765   -10.55040 6.70581   1.000 77.05801  ? 91  HIS L N   1 
ATOM   2305 C CA  . HIS B 2 93  ? 10.32468  -11.78227 6.67782   1.000 71.53350  ? 91  HIS L CA  1 
ATOM   2306 C C   . HIS B 2 93  ? 11.80847  -11.44290 6.69827   1.000 70.92974  ? 91  HIS L C   1 
ATOM   2307 O O   . HIS B 2 93  ? 12.26611  -10.58009 5.94216   1.000 81.37469  ? 91  HIS L O   1 
ATOM   2308 C CB  . HIS B 2 93  ? 9.98377   -12.61761 5.44295   1.000 59.94368  ? 91  HIS L CB  1 
ATOM   2309 C CG  . HIS B 2 93  ? 10.88065  -13.80034 5.24471   1.000 69.43400  ? 91  HIS L CG  1 
ATOM   2310 N ND1 . HIS B 2 93  ? 11.91172  -13.80593 4.32941   1.000 75.00326  ? 91  HIS L ND1 1 
ATOM   2311 C CD2 . HIS B 2 93  ? 10.89973  -15.01666 5.84023   1.000 69.22589  ? 91  HIS L CD2 1 
ATOM   2312 C CE1 . HIS B 2 93  ? 12.52457  -14.97573 4.36683   1.000 76.18698  ? 91  HIS L CE1 1 
ATOM   2313 N NE2 . HIS B 2 93  ? 11.93086  -15.72811 5.27616   1.000 73.84267  ? 91  HIS L NE2 1 
ATOM   2314 N N   . TYR B 2 94  ? 12.54896  -12.10942 7.57771   1.000 69.82185  ? 92  TYR L N   1 
ATOM   2315 C CA  . TYR B 2 94  ? 13.98633  -11.92825 7.69228   1.000 76.04034  ? 92  TYR L CA  1 
ATOM   2316 C C   . TYR B 2 94  ? 14.65949  -13.28818 7.76700   1.000 71.51144  ? 92  TYR L C   1 
ATOM   2317 O O   . TYR B 2 94  ? 14.07656  -14.26802 8.23537   1.000 75.21737  ? 92  TYR L O   1 
ATOM   2318 C CB  . TYR B 2 94  ? 14.35523  -11.09692 8.92074   1.000 61.34214  ? 92  TYR L CB  1 
ATOM   2319 C CG  . TYR B 2 94  ? 13.71758  -9.73329  8.92474   1.000 72.62058  ? 92  TYR L CG  1 
ATOM   2320 C CD1 . TYR B 2 94  ? 14.24603  -8.70134  8.17765   1.000 75.55116  ? 92  TYR L CD1 1 
ATOM   2321 C CD2 . TYR B 2 94  ? 12.57795  -9.47973  9.66997   1.000 84.68582  ? 92  TYR L CD2 1 
ATOM   2322 C CE1 . TYR B 2 94  ? 13.66670  -7.45335  8.17479   1.000 83.52353  ? 92  TYR L CE1 1 
ATOM   2323 C CE2 . TYR B 2 94  ? 11.98989  -8.22747  9.67557   1.000 82.19407  ? 92  TYR L CE2 1 
ATOM   2324 C CZ  . TYR B 2 94  ? 12.54407  -7.21610  8.92283   1.000 85.14838  ? 92  TYR L CZ  1 
ATOM   2325 O OH  . TYR B 2 94  ? 11.97907  -5.96120  8.90780   1.000 91.02669  ? 92  TYR L OH  1 
ATOM   2326 N N   . GLY B 2 95  ? 15.89063  -13.34320 7.29149   1.000 69.12270  ? 93  GLY L N   1 
ATOM   2327 C CA  . GLY B 2 95  ? 16.61828  -14.58892 7.32420   1.000 76.71681  ? 93  GLY L CA  1 
ATOM   2328 C C   . GLY B 2 95  ? 18.07676  -14.38960 7.00125   1.000 73.57260  ? 93  GLY L C   1 
ATOM   2329 O O   . GLY B 2 95  ? 18.42975  -13.47095 6.25863   1.000 86.02390  ? 93  GLY L O   1 
ATOM   2330 N N   . SER B 2 96  ? 18.93611  -15.23412 7.56039   1.000 74.61694  ? 94  SER L N   1 
ATOM   2331 C CA  . SER B 2 96  ? 20.35204  -15.16343 7.23851   1.000 74.97370  ? 94  SER L CA  1 
ATOM   2332 C C   . SER B 2 96  ? 20.81235  -16.50243 6.68332   1.000 84.79654  ? 94  SER L C   1 
ATOM   2333 O O   . SER B 2 96  ? 20.79237  -16.71609 5.46805   1.000 87.92781  ? 94  SER L O   1 
ATOM   2334 C CB  . SER B 2 96  ? 21.17183  -14.76136 8.46675   1.000 85.38260  ? 94  SER L CB  1 
ATOM   2335 O OG  . SER B 2 96  ? 20.89284  -15.60512 9.57004   1.000 90.95188  ? 94  SER L OG  1 
ATOM   2336 N N   . GLU B 2 97  ? 21.21138  -17.41703 7.56161   1.000 91.03165  ? 95  GLU L N   1 
ATOM   2337 C CA  . GLU B 2 97  ? 21.72098  -18.70812 7.12156   1.000 80.91187  ? 95  GLU L CA  1 
ATOM   2338 C C   . GLU B 2 97  ? 20.89517  -19.82685 7.72845   1.000 89.16639  ? 95  GLU L C   1 
ATOM   2339 O O   . GLU B 2 97  ? 20.07160  -20.44437 7.04458   1.000 90.48238  ? 95  GLU L O   1 
ATOM   2340 C CB  . GLU B 2 97  ? 23.19046  -18.85891 7.50813   1.000 77.00716  ? 95  GLU L CB  1 
ATOM   2341 C CG  . GLU B 2 97  ? 24.04244  -17.69332 7.05557   1.000 86.63704  ? 95  GLU L CG  1 
ATOM   2342 C CD  . GLU B 2 97  ? 25.37080  -17.61108 7.77770   1.000 90.70281  ? 95  GLU L CD  1 
ATOM   2343 O OE1 . GLU B 2 97  ? 26.00227  -18.66989 7.98398   1.000 87.75184  ? 95  GLU L OE1 1 
ATOM   2344 O OE2 . GLU B 2 97  ? 25.77713  -16.48491 8.14405   1.000 93.06048  ? 95  GLU L OE2 1 
ATOM   2345 N N   . ASN B 2 98  A 21.12288  -20.09279 9.01423   1.000 93.31782  ? 95  ASN L N   1 
ATOM   2346 C CA  . ASN B 2 98  A 20.34374  -21.05370 9.77821   1.000 102.40281 ? 95  ASN L CA  1 
ATOM   2347 C C   . ASN B 2 98  A 19.19727  -20.39173 10.54001  1.000 103.31286 ? 95  ASN L C   1 
ATOM   2348 O O   . ASN B 2 98  A 18.66945  -20.97801 11.49381  1.000 78.10681  ? 95  ASN L O   1 
ATOM   2349 C CB  . ASN B 2 98  A 21.25995  -21.81878 10.73411  1.000 100.61542 ? 95  ASN L CB  1 
ATOM   2350 C CG  . ASN B 2 98  A 22.34160  -22.59484 10.00489  1.000 99.25501  ? 95  ASN L CG  1 
ATOM   2351 O OD1 . ASN B 2 98  A 22.17828  -22.96440 8.84225   1.000 107.33912 ? 95  ASN L OD1 1 
ATOM   2352 N ND2 . ASN B 2 98  A 23.45108  -22.85082 10.68815  1.000 96.08102  ? 95  ASN L ND2 1 
ATOM   2353 N N   . ASP B 2 99  B 18.80392  -19.18496 10.13184  1.000 108.50779 ? 95  ASP L N   1 
ATOM   2354 C CA  . ASP B 2 99  B 17.72621  -18.43571 10.76196  1.000 96.26143  ? 95  ASP L CA  1 
ATOM   2355 C C   . ASP B 2 99  B 16.79820  -17.89595 9.68444   1.000 99.02121  ? 95  ASP L C   1 
ATOM   2356 O O   . ASP B 2 99  B 17.26066  -17.35249 8.67549   1.000 99.12248  ? 95  ASP L O   1 
ATOM   2357 C CB  . ASP B 2 99  B 18.27375  -17.28267 11.61199  1.000 99.21782  ? 95  ASP L CB  1 
ATOM   2358 C CG  . ASP B 2 99  B 19.52443  -17.66697 12.37679  1.000 102.51604 ? 95  ASP L CG  1 
ATOM   2359 O OD1 . ASP B 2 99  B 20.62594  -17.61338 11.78304  1.000 93.46302  ? 95  ASP L OD1 1 
ATOM   2360 O OD2 . ASP B 2 99  B 19.40340  -18.02904 13.56845  1.000 95.35010  ? 95  ASP L OD2 1 
ATOM   2361 N N   . ALA B 2 100 C 15.49414  -18.05882 9.90204   1.000 104.82728 ? 95  ALA L N   1 
ATOM   2362 C CA  . ALA B 2 100 C 14.46378  -17.52415 9.02003   1.000 93.08150  ? 95  ALA L CA  1 
ATOM   2363 C C   . ALA B 2 100 C 13.16011  -17.50320 9.80108   1.000 88.60799  ? 95  ALA L C   1 
ATOM   2364 O O   . ALA B 2 100 C 12.81347  -18.49364 10.45218  1.000 96.29630  ? 95  ALA L O   1 
ATOM   2365 C CB  . ALA B 2 100 C 14.32207  -18.35988 7.74380   1.000 82.00957  ? 95  ALA L CB  1 
ATOM   2366 N N   . TYR B 2 101 D 12.44488  -16.38446 9.73596   1.000 87.12779  ? 95  TYR L N   1 
ATOM   2367 C CA  . TYR B 2 101 D 11.29850  -16.17687 10.60952  1.000 77.85873  ? 95  TYR L CA  1 
ATOM   2368 C C   . TYR B 2 101 D 10.57352  -14.90666 10.18512  1.000 70.88396  ? 95  TYR L C   1 
ATOM   2369 O O   . TYR B 2 101 D 11.17029  -14.01086 9.58276   1.000 76.44793  ? 95  TYR L O   1 
ATOM   2370 C CB  . TYR B 2 101 D 11.74526  -16.07456 12.07272  1.000 70.51362  ? 95  TYR L CB  1 
ATOM   2371 C CG  . TYR B 2 101 D 12.78041  -14.99429 12.28778  1.000 76.28747  ? 95  TYR L CG  1 
ATOM   2372 C CD1 . TYR B 2 101 D 14.13503  -15.25175 12.11981  1.000 81.58836  ? 95  TYR L CD1 1 
ATOM   2373 C CD2 . TYR B 2 101 D 12.40067  -13.71060 12.64190  1.000 72.54189  ? 95  TYR L CD2 1 
ATOM   2374 C CE1 . TYR B 2 101 D 15.07864  -14.25766 12.30944  1.000 80.31301  ? 95  TYR L CE1 1 
ATOM   2375 C CE2 . TYR B 2 101 D 13.33339  -12.71655 12.83404  1.000 79.98387  ? 95  TYR L CE2 1 
ATOM   2376 C CZ  . TYR B 2 101 D 14.66875  -12.98803 12.66350  1.000 78.08280  ? 95  TYR L CZ  1 
ATOM   2377 O OH  . TYR B 2 101 D 15.58577  -11.98023 12.86434  1.000 76.29152  ? 95  TYR L OH  1 
ATOM   2378 N N   . TYR B 2 102 ? 9.28484   -14.84438 10.49771  1.000 69.63974  ? 96  TYR L N   1 
ATOM   2379 C CA  . TYR B 2 102 ? 8.48582   -13.64120 10.32151  1.000 61.12784  ? 96  TYR L CA  1 
ATOM   2380 C C   . TYR B 2 102 ? 8.34584   -12.92370 11.65968  1.000 56.69489  ? 96  TYR L C   1 
ATOM   2381 O O   . TYR B 2 102 ? 8.42426   -13.53343 12.72499  1.000 58.27744  ? 96  TYR L O   1 
ATOM   2382 C CB  . TYR B 2 102 ? 7.10093   -13.97940 9.76823   1.000 63.52160  ? 96  TYR L CB  1 
ATOM   2383 C CG  . TYR B 2 102 ? 7.07251   -14.55426 8.36572   1.000 65.01200  ? 96  TYR L CG  1 
ATOM   2384 C CD1 . TYR B 2 102 ? 7.18562   -15.91890 8.14989   1.000 64.41807  ? 96  TYR L CD1 1 
ATOM   2385 C CD2 . TYR B 2 102 ? 6.88768   -13.73327 7.26007   1.000 66.17078  ? 96  TYR L CD2 1 
ATOM   2386 C CE1 . TYR B 2 102 ? 7.13326   -16.44949 6.86987   1.000 63.59414  ? 96  TYR L CE1 1 
ATOM   2387 C CE2 . TYR B 2 102 ? 6.83489   -14.25609 5.97575   1.000 59.59109  ? 96  TYR L CE2 1 
ATOM   2388 C CZ  . TYR B 2 102 ? 6.95864   -15.61285 5.78797   1.000 60.55347  ? 96  TYR L CZ  1 
ATOM   2389 O OH  . TYR B 2 102 ? 6.90650   -16.13261 4.51426   1.000 65.73016  ? 96  TYR L OH  1 
ATOM   2390 N N   . ALA B 2 103 ? 8.13437   -11.61367 11.60350  1.000 59.31158  ? 97  ALA L N   1 
ATOM   2391 C CA  . ALA B 2 103 ? 8.04444   -10.82200 12.82533  1.000 59.35064  ? 97  ALA L CA  1 
ATOM   2392 C C   . ALA B 2 103 ? 6.91206   -9.81881  12.69309  1.000 59.97109  ? 97  ALA L C   1 
ATOM   2393 O O   . ALA B 2 103 ? 6.97475   -8.91629  11.85347  1.000 66.19853  ? 97  ALA L O   1 
ATOM   2394 C CB  . ALA B 2 103 ? 9.36304   -10.10452 13.12189  1.000 72.04780  ? 97  ALA L CB  1 
ATOM   2395 N N   . PHE B 2 104 ? 5.88990   -9.97113  13.52667  1.000 59.08243  ? 98  PHE L N   1 
ATOM   2396 C CA  . PHE B 2 104 ? 4.74979   -9.07050  13.51908  1.000 57.15093  ? 98  PHE L CA  1 
ATOM   2397 C C   . PHE B 2 104 ? 5.01731   -7.86581  14.40966  1.000 50.73712  ? 98  PHE L C   1 
ATOM   2398 O O   . PHE B 2 104 ? 5.89897   -7.87530  15.27044  1.000 64.50287  ? 98  PHE L O   1 
ATOM   2399 C CB  . PHE B 2 104 ? 3.48150   -9.79629  13.97594  1.000 49.10537  ? 98  PHE L CB  1 
ATOM   2400 C CG  . PHE B 2 104 ? 3.02007   -10.86424 13.02242  1.000 42.54648  ? 98  PHE L CG  1 
ATOM   2401 C CD1 . PHE B 2 104 ? 3.55296   -12.14004 13.07583  1.000 44.96856  ? 98  PHE L CD1 1 
ATOM   2402 C CD2 . PHE B 2 104 ? 2.05760   -10.58996 12.06821  1.000 52.73034  ? 98  PHE L CD2 1 
ATOM   2403 C CE1 . PHE B 2 104 ? 3.13358   -13.12118 12.19545  1.000 47.96357  ? 98  PHE L CE1 1 
ATOM   2404 C CE2 . PHE B 2 104 ? 1.62962   -11.56997 11.19163  1.000 46.16087  ? 98  PHE L CE2 1 
ATOM   2405 C CZ  . PHE B 2 104 ? 2.17026   -12.83463 11.25490  1.000 46.07202  ? 98  PHE L CZ  1 
ATOM   2406 N N   . GLY B 2 105 ? 4.25817   -6.81801  14.17564  1.000 57.60687  ? 99  GLY L N   1 
ATOM   2407 C CA  . GLY B 2 105 ? 4.30018   -5.66625  15.04306  1.000 63.62825  ? 99  GLY L CA  1 
ATOM   2408 C C   . GLY B 2 105 ? 3.35214   -5.81463  16.21241  1.000 68.94064  ? 99  GLY L C   1 
ATOM   2409 O O   . GLY B 2 105 ? 2.49478   -6.69905  16.24968  1.000 65.37828  ? 99  GLY L O   1 
ATOM   2410 N N   . GLN B 2 106 ? 3.53338   -4.93132  17.19365  1.000 77.92408  ? 100 GLN L N   1 
ATOM   2411 C CA  . GLN B 2 106 ? 2.63175   -4.89603  18.33638  1.000 72.98873  ? 100 GLN L CA  1 
ATOM   2412 C C   . GLN B 2 106 ? 1.18832   -4.64074  17.91871  1.000 67.52116  ? 100 GLN L C   1 
ATOM   2413 O O   . GLN B 2 106 ? 0.26406   -5.01671  18.64958  1.000 73.37992  ? 100 GLN L O   1 
ATOM   2414 C CB  . GLN B 2 106 ? 3.09848   -3.82318  19.31998  1.000 77.69120  ? 100 GLN L CB  1 
ATOM   2415 C CG  . GLN B 2 106 ? 3.42312   -2.49173  18.65705  1.000 81.71223  ? 100 GLN L CG  1 
ATOM   2416 C CD  . GLN B 2 106 ? 3.15138   -1.29779  19.56001  1.000 95.18277  ? 100 GLN L CD  1 
ATOM   2417 O OE1 . GLN B 2 106 ? 2.82432   -0.20561  19.08445  1.000 80.86154  ? 100 GLN L OE1 1 
ATOM   2418 N NE2 . GLN B 2 106 ? 3.27877   -1.50203  20.87073  1.000 104.42152 ? 100 GLN L NE2 1 
ATOM   2419 N N   . GLY B 2 107 ? 0.97772   -4.03017  16.75916  1.000 55.85948  ? 101 GLY L N   1 
ATOM   2420 C CA  . GLY B 2 107 ? -0.34224  -3.66862  16.29493  1.000 57.04874  ? 101 GLY L CA  1 
ATOM   2421 C C   . GLY B 2 107 ? -0.64625  -2.19672  16.52631  1.000 57.97221  ? 101 GLY L C   1 
ATOM   2422 O O   . GLY B 2 107 ? 0.02386   -1.50075  17.28892  1.000 63.02935  ? 101 GLY L O   1 
ATOM   2423 N N   . THR B 2 108 ? -1.68104  -1.71396  15.84303  1.000 57.80777  ? 102 THR L N   1 
ATOM   2424 C CA  . THR B 2 108 ? -2.14013  -0.33478  15.99125  1.000 53.34679  ? 102 THR L CA  1 
ATOM   2425 C C   . THR B 2 108 ? -3.66021  -0.33981  15.93472  1.000 69.72706  ? 102 THR L C   1 
ATOM   2426 O O   . THR B 2 108 ? -4.24491  -0.61898  14.88316  1.000 63.66394  ? 102 THR L O   1 
ATOM   2427 C CB  . THR B 2 108 ? -1.56505  0.57242   14.90383  1.000 67.80031  ? 102 THR L CB  1 
ATOM   2428 O OG1 . THR B 2 108 ? -0.13870  0.63588   15.02741  1.000 76.48598  ? 102 THR L OG1 1 
ATOM   2429 C CG2 . THR B 2 108 ? -2.14651  1.97628   15.01815  1.000 69.95354  ? 102 THR L CG2 1 
ATOM   2430 N N   . LYS B 2 109 ? -4.29876  -0.03291  17.05702  1.000 62.98498  ? 103 LYS L N   1 
ATOM   2431 C CA  . LYS B 2 109 ? -5.75317  -0.00678  17.12103  1.000 54.54054  ? 103 LYS L CA  1 
ATOM   2432 C C   . LYS B 2 109 ? -6.23745  1.35241   16.62968  1.000 54.89470  ? 103 LYS L C   1 
ATOM   2433 O O   . LYS B 2 109 ? -5.93687  2.38522   17.23468  1.000 60.94916  ? 103 LYS L O   1 
ATOM   2434 C CB  . LYS B 2 109 ? -6.20978  -0.28951  18.54622  1.000 67.68861  ? 103 LYS L CB  1 
ATOM   2435 C CG  . LYS B 2 109 ? -7.64706  -0.72231  18.67805  1.000 72.46223  ? 103 LYS L CG  1 
ATOM   2436 C CD  . LYS B 2 109 ? -7.93964  -1.18505  20.09905  1.000 69.43859  ? 103 LYS L CD  1 
ATOM   2437 C CE  . LYS B 2 109 ? -9.42690  -1.43010  20.28712  1.000 88.37660  ? 103 LYS L CE  1 
ATOM   2438 N NZ  . LYS B 2 109 ? -9.78296  -1.81719  21.68126  1.000 82.99947  ? 103 LYS L NZ  1 
ATOM   2439 N N   . VAL B 2 110 ? -6.97435  1.36160   15.52597  1.000 55.53859  ? 104 VAL L N   1 
ATOM   2440 C CA  . VAL B 2 110 ? -7.45131  2.60213   14.92833  1.000 56.42099  ? 104 VAL L CA  1 
ATOM   2441 C C   . VAL B 2 110 ? -8.89028  2.81636   15.37663  1.000 65.97366  ? 104 VAL L C   1 
ATOM   2442 O O   . VAL B 2 110 ? -9.80721  2.13882   14.90518  1.000 65.37738  ? 104 VAL L O   1 
ATOM   2443 C CB  . VAL B 2 110 ? -7.34320  2.57579   13.39937  1.000 63.75765  ? 104 VAL L CB  1 
ATOM   2444 C CG1 . VAL B 2 110 ? -7.99324  3.81202   12.80284  1.000 56.88310  ? 104 VAL L CG1 1 
ATOM   2445 C CG2 . VAL B 2 110 ? -5.88497  2.49128   12.97151  1.000 67.46934  ? 104 VAL L CG2 1 
ATOM   2446 N N   . GLU B 2 111 ? -9.08779  3.77393   16.27387  1.000 66.39664  ? 105 GLU L N   1 
ATOM   2447 C CA  . GLU B 2 111 ? -10.39437 4.08312   16.83250  1.000 71.14009  ? 105 GLU L CA  1 
ATOM   2448 C C   . GLU B 2 111 ? -10.91960 5.40696   16.28905  1.000 74.67186  ? 105 GLU L C   1 
ATOM   2449 O O   . GLU B 2 111 ? -10.15905 6.27165   15.85143  1.000 82.03407  ? 105 GLU L O   1 
ATOM   2450 C CB  . GLU B 2 111 ? -10.32231 4.12741   18.35888  1.000 75.04420  ? 105 GLU L CB  1 
ATOM   2451 C CG  . GLU B 2 111 ? -10.35228 2.75381   18.99455  1.000 78.06607  ? 105 GLU L CG  1 
ATOM   2452 C CD  . GLU B 2 111 ? -9.69518  2.72481   20.34971  1.000 83.78486  ? 105 GLU L CD  1 
ATOM   2453 O OE1 . GLU B 2 111 ? -8.61526  3.34651   20.49793  1.000 89.28032  ? 105 GLU L OE1 1 
ATOM   2454 O OE2 . GLU B 2 111 ? -10.26493 2.07868   21.25916  1.000 75.97656  ? 105 GLU L OE2 1 
ATOM   2455 N N   . ILE B 2 112 ? -12.24090 5.56421   16.33501  1.000 62.15891  ? 106 ILE L N   1 
ATOM   2456 C CA  . ILE B 2 112 ? -12.91954 6.69749   15.71514  1.000 71.55875  ? 106 ILE L CA  1 
ATOM   2457 C C   . ILE B 2 112 ? -13.33058 7.69344   16.79382  1.000 73.28013  ? 106 ILE L C   1 
ATOM   2458 O O   . ILE B 2 112 ? -13.93700 7.31549   17.80381  1.000 72.05062  ? 106 ILE L O   1 
ATOM   2459 C CB  . ILE B 2 112 ? -14.13325 6.24376   14.88072  1.000 73.76232  ? 106 ILE L CB  1 
ATOM   2460 C CG1 . ILE B 2 112 ? -14.86018 7.45304   14.28807  1.000 71.42684  ? 106 ILE L CG1 1 
ATOM   2461 C CG2 . ILE B 2 112 ? -15.07679 5.37090   15.69926  1.000 73.30013  ? 106 ILE L CG2 1 
ATOM   2462 C CD1 . ILE B 2 112 ? -16.02421 7.09847   13.39586  1.000 65.16626  ? 106 ILE L CD1 1 
ATOM   2463 N N   . LYS B 2 113 ? -12.99350 8.96501   16.57541  1.000 76.02372  ? 107 LYS L N   1 
ATOM   2464 C CA  . LYS B 2 113 ? -13.39117 10.04955  17.46004  1.000 63.39661  ? 107 LYS L CA  1 
ATOM   2465 C C   . LYS B 2 113 ? -14.89808 10.26468  17.42128  1.000 69.34555  ? 107 LYS L C   1 
ATOM   2466 O O   . LYS B 2 113 ? -15.57999 9.92508   16.44918  1.000 71.30017  ? 107 LYS L O   1 
ATOM   2467 C CB  . LYS B 2 113 ? -12.69788 11.35131  17.06706  1.000 59.03797  ? 107 LYS L CB  1 
ATOM   2468 C CG  . LYS B 2 113 ? -11.19212 11.30996  17.06216  1.000 66.57872  ? 107 LYS L CG  1 
ATOM   2469 C CD  . LYS B 2 113 ? -10.63386 12.55564  16.39234  1.000 70.27376  ? 107 LYS L CD  1 
ATOM   2470 C CE  . LYS B 2 113 ? -9.18283  12.77728  16.77967  1.000 75.32696  ? 107 LYS L CE  1 
ATOM   2471 N NZ  . LYS B 2 113 ? -9.02843  12.79414  18.26497  1.000 82.01435  ? 107 LYS L NZ  1 
ATOM   2472 N N   . ARG B 2 114 ? -15.40953 10.85927  18.49747  1.000 69.61712  ? 108 ARG L N   1 
ATOM   2473 C CA  . ARG B 2 114 ? -16.81503 11.22752  18.56932  1.000 55.96816  ? 108 ARG L CA  1 
ATOM   2474 C C   . ARG B 2 114 ? -16.99564 12.26893  19.66163  1.000 54.48650  ? 108 ARG L C   1 
ATOM   2475 O O   . ARG B 2 114 ? -16.05620 12.61909  20.38010  1.000 60.69057  ? 108 ARG L O   1 
ATOM   2476 C CB  . ARG B 2 114 ? -17.69906 10.01016  18.82874  1.000 60.58145  ? 108 ARG L CB  1 
ATOM   2477 C CG  . ARG B 2 114 ? -17.42613 9.32460   20.14938  1.000 68.18299  ? 108 ARG L CG  1 
ATOM   2478 C CD  . ARG B 2 114 ? -18.71452 8.78371   20.70815  1.000 59.36309  ? 108 ARG L CD  1 
ATOM   2479 N NE  . ARG B 2 114 ? -19.57716 9.86560   21.16179  1.000 61.79518  ? 108 ARG L NE  1 
ATOM   2480 C CZ  . ARG B 2 114 ? -20.89883 9.79712   21.21335  1.000 59.12730  ? 108 ARG L CZ  1 
ATOM   2481 N NH1 . ARG B 2 114 ? -21.55292 8.73189   20.77712  1.000 54.14110  ? 108 ARG L NH1 1 
ATOM   2482 N NH2 . ARG B 2 114 ? -21.58066 10.82378  21.71273  1.000 55.27487  ? 108 ARG L NH2 1 
ATOM   2483 N N   . THR B 2 115 ? -18.22388 12.76628  19.76516  1.000 61.92267  ? 109 THR L N   1 
ATOM   2484 C CA  . THR B 2 115 ? -18.56633 13.73171  20.79834  1.000 66.82672  ? 109 THR L CA  1 
ATOM   2485 C C   . THR B 2 115 ? -18.50117 13.07036  22.16751  1.000 71.88232  ? 109 THR L C   1 
ATOM   2486 O O   . THR B 2 115 ? -19.03486 11.97584  22.36161  1.000 71.34585  ? 109 THR L O   1 
ATOM   2487 C CB  . THR B 2 115 ? -19.96444 14.29075  20.55237  1.000 70.91330  ? 109 THR L CB  1 
ATOM   2488 O OG1 . THR B 2 115 ? -20.92348 13.23210  20.66473  1.000 74.32241  ? 109 THR L OG1 1 
ATOM   2489 C CG2 . THR B 2 115 ? -20.05871 14.89137  19.15824  1.000 66.55832  ? 109 THR L CG2 1 
ATOM   2490 N N   . VAL B 2 116 ? -17.83737 13.73785  23.11320  1.000 72.18113  ? 110 VAL L N   1 
ATOM   2491 C CA  . VAL B 2 116 ? -17.75992 13.24320  24.48163  1.000 66.84492  ? 110 VAL L CA  1 
ATOM   2492 C C   . VAL B 2 116 ? -19.16051 12.96898  25.00615  1.000 58.81752  ? 110 VAL L C   1 
ATOM   2493 O O   . VAL B 2 116 ? -20.07883 13.77731  24.82639  1.000 62.83093  ? 110 VAL L O   1 
ATOM   2494 C CB  . VAL B 2 116 ? -17.01247 14.25570  25.36101  1.000 65.00081  ? 110 VAL L CB  1 
ATOM   2495 C CG1 . VAL B 2 116 ? -17.07358 13.84196  26.82082  1.000 66.43897  ? 110 VAL L CG1 1 
ATOM   2496 C CG2 . VAL B 2 116 ? -15.57043 14.39325  24.88873  1.000 57.30274  ? 110 VAL L CG2 1 
ATOM   2497 N N   . ALA B 2 117 ? -19.33381 11.80861  25.63719  1.000 56.14950  ? 111 ALA L N   1 
ATOM   2498 C CA  . ALA B 2 117 ? -20.60601 11.39745  26.21739  1.000 58.70586  ? 111 ALA L CA  1 
ATOM   2499 C C   . ALA B 2 117 ? -20.37475 10.88944  27.63531  1.000 62.27947  ? 111 ALA L C   1 
ATOM   2500 O O   . ALA B 2 117 ? -19.43891 10.11923  27.87568  1.000 63.05168  ? 111 ALA L O   1 
ATOM   2501 C CB  . ALA B 2 117 ? -21.27390 10.31279  25.36836  1.000 48.23560  ? 111 ALA L CB  1 
ATOM   2502 N N   . ALA B 2 118 ? -21.23264 11.32495  28.57715  1.000 48.20842  ? 112 ALA L N   1 
ATOM   2503 C CA  . ALA B 2 118 ? -21.14078 10.89119  29.96299  1.000 51.27744  ? 112 ALA L CA  1 
ATOM   2504 C C   . ALA B 2 118 ? -21.88189 9.57132   30.15113  1.000 43.17362  ? 112 ALA L C   1 
ATOM   2505 O O   . ALA B 2 118 ? -22.96567 9.38134   29.59735  1.000 56.09387  ? 112 ALA L O   1 
ATOM   2506 C CB  . ALA B 2 118 ? -21.72506 11.94316  30.90590  1.000 52.43059  ? 112 ALA L CB  1 
ATOM   2507 N N   . PRO B 2 119 ? -21.32511 8.65533   30.93165  1.000 52.21962  ? 113 PRO L N   1 
ATOM   2508 C CA  . PRO B 2 119 ? -21.95027 7.33928   31.09907  1.000 45.18416  ? 113 PRO L CA  1 
ATOM   2509 C C   . PRO B 2 119 ? -23.21842 7.39887   31.93462  1.000 44.96456  ? 113 PRO L C   1 
ATOM   2510 O O   . PRO B 2 119 ? -23.40666 8.28551   32.76800  1.000 51.61100  ? 113 PRO L O   1 
ATOM   2511 C CB  . PRO B 2 119 ? -20.86479 6.52616   31.82005  1.000 49.45553  ? 113 PRO L CB  1 
ATOM   2512 C CG  . PRO B 2 119 ? -20.01535 7.55937   32.51444  1.000 41.97104  ? 113 PRO L CG  1 
ATOM   2513 C CD  . PRO B 2 119 ? -20.04006 8.77660   31.64737  1.000 40.96883  ? 113 PRO L CD  1 
ATOM   2514 N N   . SER B 2 120 ? -24.10027 6.43369   31.69615  1.000 40.78510  ? 114 SER L N   1 
ATOM   2515 C CA  . SER B 2 120 ? -25.17206 6.12452   32.63407  1.000 42.39305  ? 114 SER L CA  1 
ATOM   2516 C C   . SER B 2 120 ? -24.58995 5.16618   33.66177  1.000 51.81271  ? 114 SER L C   1 
ATOM   2517 O O   . SER B 2 120 ? -24.23015 4.03501   33.32247  1.000 49.52077  ? 114 SER L O   1 
ATOM   2518 C CB  . SER B 2 120 ? -26.37342 5.50848   31.92397  1.000 37.07252  ? 114 SER L CB  1 
ATOM   2519 O OG  . SER B 2 120 ? -26.89313 6.38091   30.93207  1.000 56.94571  ? 114 SER L OG  1 
ATOM   2520 N N   . VAL B 2 121 ? -24.45837 5.62260   34.90424  1.000 47.18351  ? 115 VAL L N   1 
ATOM   2521 C CA  . VAL B 2 121 ? -23.82428 4.82467   35.94402  1.000 30.88490  ? 115 VAL L CA  1 
ATOM   2522 C C   . VAL B 2 121 ? -24.89004 4.05201   36.70072  1.000 40.98550  ? 115 VAL L C   1 
ATOM   2523 O O   . VAL B 2 121 ? -25.91349 4.61398   37.11254  1.000 49.98185  ? 115 VAL L O   1 
ATOM   2524 C CB  . VAL B 2 121 ? -22.99934 5.70257   36.89167  1.000 39.75131  ? 115 VAL L CB  1 
ATOM   2525 C CG1 . VAL B 2 121 ? -22.37251 4.83980   37.97069  1.000 38.33089  ? 115 VAL L CG1 1 
ATOM   2526 C CG2 . VAL B 2 121 ? -21.92961 6.46186   36.10882  1.000 29.08306  ? 115 VAL L CG2 1 
ATOM   2527 N N   . PHE B 2 122 ? -24.65322 2.75574   36.86823  1.000 37.79957  ? 116 PHE L N   1 
ATOM   2528 C CA  . PHE B 2 122 ? -25.53802 1.86507   37.59658  1.000 39.51759  ? 116 PHE L CA  1 
ATOM   2529 C C   . PHE B 2 122 ? -24.71737 1.05056   38.58203  1.000 34.30845  ? 116 PHE L C   1 
ATOM   2530 O O   . PHE B 2 122 ? -23.59256 0.64639   38.27868  1.000 40.70079  ? 116 PHE L O   1 
ATOM   2531 C CB  . PHE B 2 122 ? -26.27696 0.91698   36.65039  1.000 41.66316  ? 116 PHE L CB  1 
ATOM   2532 C CG  . PHE B 2 122 ? -27.03994 1.61109   35.56446  1.000 44.44562  ? 116 PHE L CG  1 
ATOM   2533 C CD1 . PHE B 2 122 ? -26.42486 1.92061   34.35367  1.000 43.95513  ? 116 PHE L CD1 1 
ATOM   2534 C CD2 . PHE B 2 122 ? -28.37907 1.93538   35.74423  1.000 38.02581  ? 116 PHE L CD2 1 
ATOM   2535 C CE1 . PHE B 2 122 ? -27.12237 2.55095   33.34548  1.000 41.81608  ? 116 PHE L CE1 1 
ATOM   2536 C CE2 . PHE B 2 122 ? -29.09056 2.56820   34.74649  1.000 40.63341  ? 116 PHE L CE2 1 
ATOM   2537 C CZ  . PHE B 2 122 ? -28.45942 2.87802   33.53642  1.000 45.88596  ? 116 PHE L CZ  1 
ATOM   2538 N N   . ILE B 2 123 ? -25.29002 0.78769   39.75377  1.000 31.83702  ? 117 ILE L N   1 
ATOM   2539 C CA  . ILE B 2 123 ? -24.63685 -0.03314  40.76709  1.000 39.52969  ? 117 ILE L CA  1 
ATOM   2540 C C   . ILE B 2 123 ? -25.56080 -1.18509  41.14215  1.000 37.59056  ? 117 ILE L C   1 
ATOM   2541 O O   . ILE B 2 123 ? -26.77032 -0.99206  41.31141  1.000 44.32492  ? 117 ILE L O   1 
ATOM   2542 C CB  . ILE B 2 123 ? -24.22567 0.79501   42.00703  1.000 36.83327  ? 117 ILE L CB  1 
ATOM   2543 C CG1 . ILE B 2 123 ? -23.37839 -0.05234  42.96030  1.000 33.50487  ? 117 ILE L CG1 1 
ATOM   2544 C CG2 . ILE B 2 123 ? -25.44311 1.40095   42.71988  1.000 33.84113  ? 117 ILE L CG2 1 
ATOM   2545 C CD1 . ILE B 2 123 ? -22.76680 0.73613   44.10152  1.000 39.54151  ? 117 ILE L CD1 1 
ATOM   2546 N N   . PHE B 2 124 ? -24.98429 -2.38521  41.25513  1.000 30.94522  ? 118 PHE L N   1 
ATOM   2547 C CA  . PHE B 2 124 ? -25.71946 -3.62432  41.50099  1.000 35.99083  ? 118 PHE L CA  1 
ATOM   2548 C C   . PHE B 2 124 ? -25.24962 -4.27571  42.79033  1.000 42.53319  ? 118 PHE L C   1 
ATOM   2549 O O   . PHE B 2 124 ? -24.09595 -4.72537  42.85815  1.000 39.20230  ? 118 PHE L O   1 
ATOM   2550 C CB  . PHE B 2 124 ? -25.54076 -4.61057  40.35325  1.000 33.86345  ? 118 PHE L CB  1 
ATOM   2551 C CG  . PHE B 2 124 ? -26.06597 -4.11877  39.05658  1.000 41.54062  ? 118 PHE L CG  1 
ATOM   2552 C CD1 . PHE B 2 124 ? -27.40062 -4.30026  38.73054  1.000 40.41820  ? 118 PHE L CD1 1 
ATOM   2553 C CD2 . PHE B 2 124 ? -25.23433 -3.47632  38.15604  1.000 39.47473  ? 118 PHE L CD2 1 
ATOM   2554 C CE1 . PHE B 2 124 ? -27.90200 -3.85612  37.53446  1.000 33.11358  ? 118 PHE L CE1 1 
ATOM   2555 C CE2 . PHE B 2 124 ? -25.73184 -3.02323  36.95601  1.000 45.00102  ? 118 PHE L CE2 1 
ATOM   2556 C CZ  . PHE B 2 124 ? -27.07518 -3.21519  36.64348  1.000 32.96365  ? 118 PHE L CZ  1 
ATOM   2557 N N   . PRO B 2 125 ? -26.09683 -4.40210  43.80499  1.000 42.00520  ? 119 PRO L N   1 
ATOM   2558 C CA  . PRO B 2 125 ? -25.70453 -5.12031  45.01281  1.000 39.73923  ? 119 PRO L CA  1 
ATOM   2559 C C   . PRO B 2 125 ? -25.54055 -6.59913  44.71790  1.000 43.31781  ? 119 PRO L C   1 
ATOM   2560 O O   . PRO B 2 125 ? -26.08384 -7.10022  43.72309  1.000 44.27256  ? 119 PRO L O   1 
ATOM   2561 C CB  . PRO B 2 125 ? -26.88331 -4.87415  45.97587  1.000 38.91594  ? 119 PRO L CB  1 
ATOM   2562 C CG  . PRO B 2 125 ? -27.71496 -3.79956  45.34765  1.000 34.48741  ? 119 PRO L CG  1 
ATOM   2563 C CD  . PRO B 2 125 ? -27.48479 -3.91941  43.87736  1.000 39.02396  ? 119 PRO L CD  1 
ATOM   2564 N N   . PRO B 2 126 ? -24.80925 -7.33307  45.55768  1.000 42.61342  ? 120 PRO L N   1 
ATOM   2565 C CA  . PRO B 2 126 ? -24.69868 -8.78256  45.35760  1.000 40.01488  ? 120 PRO L CA  1 
ATOM   2566 C C   . PRO B 2 126 ? -26.04032 -9.45743  45.58125  1.000 36.42847  ? 120 PRO L C   1 
ATOM   2567 O O   . PRO B 2 126 ? -26.85002 -9.01120  46.39606  1.000 42.33974  ? 120 PRO L O   1 
ATOM   2568 C CB  . PRO B 2 126 ? -23.68140 -9.20828  46.42002  1.000 44.65827  ? 120 PRO L CB  1 
ATOM   2569 C CG  . PRO B 2 126 ? -23.84430 -8.18972  47.49733  1.000 42.16904  ? 120 PRO L CG  1 
ATOM   2570 C CD  . PRO B 2 126 ? -24.13583 -6.89401  46.79127  1.000 38.17072  ? 120 PRO L CD  1 
ATOM   2571 N N   . SER B 2 127 ? -26.28087 -10.53525 44.84482  1.000 39.15828  ? 121 SER L N   1 
ATOM   2572 C CA  . SER B 2 127 ? -27.53591 -11.25252 45.00993  1.000 42.04953  ? 121 SER L CA  1 
ATOM   2573 C C   . SER B 2 127 ? -27.48965 -12.09731 46.27371  1.000 43.61586  ? 121 SER L C   1 
ATOM   2574 O O   . SER B 2 127 ? -26.43465 -12.59146 46.67305  1.000 51.11263  ? 121 SER L O   1 
ATOM   2575 C CB  . SER B 2 127 ? -27.80484 -12.15277 43.81613  1.000 34.71953  ? 121 SER L CB  1 
ATOM   2576 O OG  . SER B 2 127 ? -27.02080 -13.32444 43.93333  1.000 43.78598  ? 121 SER L OG  1 
ATOM   2577 N N   . ASP B 2 128 ? -28.65374 -12.27659 46.90300  1.000 48.73484  ? 122 ASP L N   1 
ATOM   2578 C CA  . ASP B 2 128 ? -28.69423 -13.09742 48.10944  1.000 51.73161  ? 122 ASP L CA  1 
ATOM   2579 C C   . ASP B 2 128 ? -28.19415 -14.50689 47.83738  1.000 52.83862  ? 122 ASP L C   1 
ATOM   2580 O O   . ASP B 2 128 ? -27.56662 -15.12154 48.70993  1.000 47.64004  ? 122 ASP L O   1 
ATOM   2581 C CB  . ASP B 2 128 ? -30.10963 -13.13730 48.68001  1.000 51.15228  ? 122 ASP L CB  1 
ATOM   2582 C CG  . ASP B 2 128 ? -30.61857 -11.77135 49.03927  1.000 52.08533  ? 122 ASP L CG  1 
ATOM   2583 O OD1 . ASP B 2 128 ? -29.78302 -10.87116 49.25890  1.000 60.33149  ? 122 ASP L OD1 1 
ATOM   2584 O OD2 . ASP B 2 128 ? -31.85200 -11.59870 49.10631  1.000 62.86429  ? 122 ASP L OD2 1 
ATOM   2585 N N   . GLU B 2 129 ? -28.44151 -15.01825 46.62759  1.000 44.53712  ? 123 GLU L N   1 
ATOM   2586 C CA  . GLU B 2 129 ? -27.96544 -16.34515 46.26116  1.000 45.92131  ? 123 GLU L CA  1 
ATOM   2587 C C   . GLU B 2 129 ? -26.44945 -16.43773 46.37010  1.000 51.71458  ? 123 GLU L C   1 
ATOM   2588 O O   . GLU B 2 129 ? -25.91133 -17.45852 46.81391  1.000 59.05884  ? 123 GLU L O   1 
ATOM   2589 C CB  . GLU B 2 129 ? -28.42857 -16.67298 44.84603  1.000 40.11456  ? 123 GLU L CB  1 
ATOM   2590 C CG  . GLU B 2 129 ? -28.05906 -18.05625 44.36574  1.000 53.01031  ? 123 GLU L CG  1 
ATOM   2591 C CD  . GLU B 2 129 ? -28.61855 -18.34630 42.98202  1.000 68.55795  ? 123 GLU L CD  1 
ATOM   2592 O OE1 . GLU B 2 129 ? -29.33278 -17.46876 42.44072  1.000 59.90590  ? 123 GLU L OE1 1 
ATOM   2593 O OE2 . GLU B 2 129 ? -28.34359 -19.44388 42.43893  1.000 63.93886  ? 123 GLU L OE2 1 
ATOM   2594 N N   . GLN B 2 130 ? -25.74122 -15.37262 45.98988  1.000 51.00289  ? 124 GLN L N   1 
ATOM   2595 C CA  . GLN B 2 130 ? -24.28889 -15.40528 46.09195  1.000 47.93995  ? 124 GLN L CA  1 
ATOM   2596 C C   . GLN B 2 130 ? -23.82557 -15.37595 47.53920  1.000 50.59370  ? 124 GLN L C   1 
ATOM   2597 O O   . GLN B 2 130 ? -22.85147 -16.05291 47.88342  1.000 59.90271  ? 124 GLN L O   1 
ATOM   2598 C CB  . GLN B 2 130 ? -23.65915 -14.24423 45.32496  1.000 45.24457  ? 124 GLN L CB  1 
ATOM   2599 C CG  . GLN B 2 130 ? -22.17247 -14.45881 45.08719  1.000 50.70335  ? 124 GLN L CG  1 
ATOM   2600 C CD  . GLN B 2 130 ? -21.47378 -13.24466 44.53865  1.000 44.56609  ? 124 GLN L CD  1 
ATOM   2601 O OE1 . GLN B 2 130 ? -21.97576 -12.12469 44.63150  1.000 42.08088  ? 124 GLN L OE1 1 
ATOM   2602 N NE2 . GLN B 2 130 ? -20.29635 -13.45658 43.96706  1.000 52.40221  ? 124 GLN L NE2 1 
ATOM   2603 N N   . LEU B 2 131 ? -24.49608 -14.59783 48.39496  1.000 54.16887  ? 125 LEU L N   1 
ATOM   2604 C CA  . LEU B 2 131 ? -24.07187 -14.49272 49.78891  1.000 53.14387  ? 125 LEU L CA  1 
ATOM   2605 C C   . LEU B 2 131 ? -23.97959 -15.85802 50.45377  1.000 61.43242  ? 125 LEU L C   1 
ATOM   2606 O O   . LEU B 2 131 ? -23.05673 -16.10299 51.24019  1.000 67.27357  ? 125 LEU L O   1 
ATOM   2607 C CB  . LEU B 2 131 ? -25.02662 -13.58825 50.56109  1.000 51.10069  ? 125 LEU L CB  1 
ATOM   2608 C CG  . LEU B 2 131 ? -24.99345 -12.12810 50.11705  1.000 55.38924  ? 125 LEU L CG  1 
ATOM   2609 C CD1 . LEU B 2 131 ? -25.85507 -11.28789 51.03496  1.000 47.05939  ? 125 LEU L CD1 1 
ATOM   2610 C CD2 . LEU B 2 131 ? -23.55927 -11.61107 50.09477  1.000 46.44362  ? 125 LEU L CD2 1 
ATOM   2611 N N   . LYS B 2 132 ? -24.90767 -16.76384 50.13395  1.000 62.16924  ? 126 LYS L N   1 
ATOM   2612 C CA  . LYS B 2 132 ? -24.85126 -18.11998 50.66842  1.000 66.43944  ? 126 LYS L CA  1 
ATOM   2613 C C   . LYS B 2 132 ? -23.53528 -18.81758 50.35626  1.000 68.18614  ? 126 LYS L C   1 
ATOM   2614 O O   . LYS B 2 132 ? -23.14745 -19.73782 51.08354  1.000 86.21438  ? 126 LYS L O   1 
ATOM   2615 C CB  . LYS B 2 132 ? -26.00601 -18.94832 50.11492  1.000 61.35292  ? 126 LYS L CB  1 
ATOM   2616 C CG  . LYS B 2 132 ? -27.36180 -18.34293 50.38238  1.000 58.37270  ? 126 LYS L CG  1 
ATOM   2617 C CD  . LYS B 2 132 ? -28.48054 -19.28920 49.99454  1.000 61.06991  ? 126 LYS L CD  1 
ATOM   2618 C CE  . LYS B 2 132 ? -28.39874 -19.71254 48.54072  1.000 59.70876  ? 126 LYS L CE  1 
ATOM   2619 N NZ  . LYS B 2 132 ? -29.68179 -20.35914 48.12419  1.000 76.55838  ? 126 LYS L NZ  1 
ATOM   2620 N N   . SER B 2 133 ? -22.84609 -18.41322 49.29430  1.000 61.58497  ? 127 SER L N   1 
ATOM   2621 C CA  A SER B 2 133 ? -21.56753 -18.99952 48.91637  0.491 60.91695  ? 127 SER L CA  1 
ATOM   2622 C CA  B SER B 2 133 ? -21.57181 -19.01651 48.93375  0.509 60.90459  ? 127 SER L CA  1 
ATOM   2623 C C   . SER B 2 133 ? -20.38868 -18.37241 49.64633  1.000 64.02505  ? 127 SER L C   1 
ATOM   2624 O O   . SER B 2 133 ? -19.24377 -18.77486 49.40327  1.000 55.22302  ? 127 SER L O   1 
ATOM   2625 C CB  A SER B 2 133 ? -21.34996 -18.86867 47.40521  0.491 65.91103  ? 127 SER L CB  1 
ATOM   2626 C CB  B SER B 2 133 ? -21.37202 -18.94650 47.41617  0.509 65.89187  ? 127 SER L CB  1 
ATOM   2627 O OG  A SER B 2 133 ? -20.85773 -17.58011 47.06738  0.491 58.17457  ? 127 SER L OG  1 
ATOM   2628 O OG  B SER B 2 133 ? -22.46626 -19.53975 46.73239  0.509 63.71670  ? 127 SER L OG  1 
ATOM   2629 N N   . GLY B 2 134 ? -20.63433 -17.38933 50.51628  1.000 56.27250  ? 128 GLY L N   1 
ATOM   2630 C CA  . GLY B 2 134 ? -19.58143 -16.76726 51.28822  1.000 66.21809  ? 128 GLY L CA  1 
ATOM   2631 C C   . GLY B 2 134 ? -18.91449 -15.55729 50.66314  1.000 62.85145  ? 128 GLY L C   1 
ATOM   2632 O O   . GLY B 2 134 ? -18.15333 -14.86573 51.35780  1.000 49.39260  ? 128 GLY L O   1 
ATOM   2633 N N   . THR B 2 135 ? -19.16664 -15.27130 49.38737  1.000 61.00092  ? 129 THR L N   1 
ATOM   2634 C CA  . THR B 2 135 ? -18.57259 -14.12053 48.72535  1.000 57.96677  ? 129 THR L CA  1 
ATOM   2635 C C   . THR B 2 135 ? -19.66909 -13.18626 48.22803  1.000 53.21409  ? 129 THR L C   1 
ATOM   2636 O O   . THR B 2 135 ? -20.78248 -13.61565 47.90955  1.000 52.57782  ? 129 THR L O   1 
ATOM   2637 C CB  . THR B 2 135 ? -17.66308 -14.55272 47.55808  1.000 64.68220  ? 129 THR L CB  1 
ATOM   2638 O OG1 . THR B 2 135 ? -16.80732 -15.61818 47.98948  1.000 69.20634  ? 129 THR L OG1 1 
ATOM   2639 C CG2 . THR B 2 135 ? -16.79503 -13.39788 47.09115  1.000 50.81156  ? 129 THR L CG2 1 
ATOM   2640 N N   . ALA B 2 136 ? -19.34374 -11.89693 48.18461  1.000 52.09748  ? 130 ALA L N   1 
ATOM   2641 C CA  . ALA B 2 136 ? -20.22639 -10.85999 47.66789  1.000 49.89831  ? 130 ALA L CA  1 
ATOM   2642 C C   . ALA B 2 136 ? -19.49806 -10.07794 46.58482  1.000 51.26397  ? 130 ALA L C   1 
ATOM   2643 O O   . ALA B 2 136 ? -18.51543 -9.39063  46.87811  1.000 51.73115  ? 130 ALA L O   1 
ATOM   2644 C CB  . ALA B 2 136 ? -20.66922 -9.91499  48.78298  1.000 50.42628  ? 130 ALA L CB  1 
ATOM   2645 N N   . SER B 2 137 ? -19.98271 -10.16918 45.34364  1.000 43.97748  ? 131 SER L N   1 
ATOM   2646 C CA  . SER B 2 137 ? -19.53156 -9.30122  44.26080  1.000 30.88142  ? 131 SER L CA  1 
ATOM   2647 C C   . SER B 2 137 ? -20.46370 -8.09862  44.18094  1.000 35.32386  ? 131 SER L C   1 
ATOM   2648 O O   . SER B 2 137 ? -21.68574 -8.26334  44.11942  1.000 42.48852  ? 131 SER L O   1 
ATOM   2649 C CB  . SER B 2 137 ? -19.51535 -10.02960 42.91793  1.000 36.06212  ? 131 SER L CB  1 
ATOM   2650 O OG  . SER B 2 137 ? -18.88170 -11.28915 42.98966  1.000 39.86312  ? 131 SER L OG  1 
ATOM   2651 N N   . VAL B 2 138 ? -19.89822 -6.89447  44.18722  1.000 41.15874  ? 132 VAL L N   1 
ATOM   2652 C CA  . VAL B 2 138 ? -20.63905 -5.68280  43.84874  1.000 44.05167  ? 132 VAL L CA  1 
ATOM   2653 C C   . VAL B 2 138 ? -20.13961 -5.19300  42.49218  1.000 42.92838  ? 132 VAL L C   1 
ATOM   2654 O O   . VAL B 2 138 ? -18.92613 -5.09776  42.26501  1.000 41.80403  ? 132 VAL L O   1 
ATOM   2655 C CB  . VAL B 2 138 ? -20.49285 -4.59699  44.92907  1.000 38.61762  ? 132 VAL L CB  1 
ATOM   2656 C CG1 . VAL B 2 138 ? -21.59883 -3.56284  44.78450  1.000 32.97413  ? 132 VAL L CG1 1 
ATOM   2657 C CG2 . VAL B 2 138 ? -20.52056 -5.21278  46.32574  1.000 35.49916  ? 132 VAL L CG2 1 
ATOM   2658 N N   . VAL B 2 139 ? -21.07358 -4.89038  41.59291  1.000 37.06282  ? 133 VAL L N   1 
ATOM   2659 C CA  . VAL B 2 139 ? -20.77431 -4.53240  40.21104  1.000 28.88917  ? 133 VAL L CA  1 
ATOM   2660 C C   . VAL B 2 139 ? -21.21910 -3.10134  39.95674  1.000 28.83890  ? 133 VAL L C   1 
ATOM   2661 O O   . VAL B 2 139 ? -22.30074 -2.68775  40.38515  1.000 40.74382  ? 133 VAL L O   1 
ATOM   2662 C CB  . VAL B 2 139 ? -21.45710 -5.49606  39.22246  1.000 33.08411  ? 133 VAL L CB  1 
ATOM   2663 C CG1 . VAL B 2 139 ? -21.20686 -5.05858  37.77557  1.000 27.99468  ? 133 VAL L CG1 1 
ATOM   2664 C CG2 . VAL B 2 139 ? -20.95268 -6.90576  39.44711  1.000 31.88719  ? 133 VAL L CG2 1 
ATOM   2665 N N   . CYS B 2 140 ? -20.37769 -2.34504  39.26422  1.000 37.21109  ? 134 CYS L N   1 
ATOM   2666 C CA  . CYS B 2 140 ? -20.69205 -0.99122  38.82868  1.000 43.72561  ? 134 CYS L CA  1 
ATOM   2667 C C   . CYS B 2 140 ? -20.62833 -0.94243  37.30946  1.000 46.79407  ? 134 CYS L C   1 
ATOM   2668 O O   . CYS B 2 140 ? -19.65504 -1.41512  36.71750  1.000 45.63692  ? 134 CYS L O   1 
ATOM   2669 C CB  . CYS B 2 140 ? -19.71456 0.01184   39.42739  1.000 38.22484  ? 134 CYS L CB  1 
ATOM   2670 S SG  . CYS B 2 140 ? -20.02586 1.71378   39.00554  1.000 50.00759  ? 134 CYS L SG  1 
ATOM   2671 N N   . LEU B 2 141 ? -21.65843 -0.38047  36.68001  1.000 45.36026  ? 135 LEU L N   1 
ATOM   2672 C CA  . LEU B 2 141 ? -21.74420 -0.31905  35.22724  1.000 37.23113  ? 135 LEU L CA  1 
ATOM   2673 C C   . LEU B 2 141 ? -21.62214 1.12374   34.76427  1.000 40.51686  ? 135 LEU L C   1 
ATOM   2674 O O   . LEU B 2 141 ? -22.31627 2.00518   35.27893  1.000 46.31580  ? 135 LEU L O   1 
ATOM   2675 C CB  . LEU B 2 141 ? -23.05713 -0.92055  34.72293  1.000 42.74772  ? 135 LEU L CB  1 
ATOM   2676 C CG  . LEU B 2 141 ? -23.38400 -0.74259  33.23283  1.000 36.45494  ? 135 LEU L CG  1 
ATOM   2677 C CD1 . LEU B 2 141 ? -22.26881 -1.27039  32.34487  1.000 46.71571  ? 135 LEU L CD1 1 
ATOM   2678 C CD2 . LEU B 2 141 ? -24.69416 -1.42089  32.89268  1.000 32.24498  ? 135 LEU L CD2 1 
ATOM   2679 N N   . LEU B 2 142 ? -20.73609 1.35712   33.80020  1.000 37.79822  ? 136 LEU L N   1 
ATOM   2680 C CA  . LEU B 2 142 ? -20.64918 2.61883   33.07120  1.000 48.45187  ? 136 LEU L CA  1 
ATOM   2681 C C   . LEU B 2 142 ? -21.03543 2.31479   31.63350  1.000 43.95356  ? 136 LEU L C   1 
ATOM   2682 O O   . LEU B 2 142 ? -20.26889 1.66451   30.91667  1.000 39.85188  ? 136 LEU L O   1 
ATOM   2683 C CB  . LEU B 2 142 ? -19.24463 3.20512   33.12783  1.000 45.72154  ? 136 LEU L CB  1 
ATOM   2684 C CG  . LEU B 2 142 ? -18.67937 3.79798   34.40943  1.000 43.20917  ? 136 LEU L CG  1 
ATOM   2685 C CD1 . LEU B 2 142 ? -18.61587 2.78299   35.52725  1.000 36.48732  ? 136 LEU L CD1 1 
ATOM   2686 C CD2 . LEU B 2 142 ? -17.30245 4.28816   34.06697  1.000 36.84923  ? 136 LEU L CD2 1 
ATOM   2687 N N   . ASN B 2 143 ? -22.20863 2.78499   31.20982  1.000 49.01338  ? 137 ASN L N   1 
ATOM   2688 C CA  . ASN B 2 143 ? -22.81093 2.37284   29.94561  1.000 43.64321  ? 137 ASN L CA  1 
ATOM   2689 C C   . ASN B 2 143 ? -22.73645 3.49044   28.91361  1.000 48.55277  ? 137 ASN L C   1 
ATOM   2690 O O   . ASN B 2 143 ? -23.13754 4.62419   29.19083  1.000 46.06728  ? 137 ASN L O   1 
ATOM   2691 C CB  . ASN B 2 143 ? -24.26291 1.95308   30.14795  1.000 38.40517  ? 137 ASN L CB  1 
ATOM   2692 C CG  . ASN B 2 143 ? -24.72562 0.98121   29.10287  1.000 51.97509  ? 137 ASN L CG  1 
ATOM   2693 O OD1 . ASN B 2 143 ? -23.94384 0.17071   28.60311  1.000 52.52324  ? 137 ASN L OD1 1 
ATOM   2694 N ND2 . ASN B 2 143 ? -25.99602 1.06065   28.74866  1.000 51.81120  ? 137 ASN L ND2 1 
ATOM   2695 N N   . ASN B 2 144 ? -22.19539 3.16043   27.73641  1.000 53.23080  ? 138 ASN L N   1 
ATOM   2696 C CA  . ASN B 2 144 ? -22.23701 3.98573   26.53147  1.000 45.63189  ? 138 ASN L CA  1 
ATOM   2697 C C   . ASN B 2 144 ? -21.65134 5.38327   26.72769  1.000 46.31396  ? 138 ASN L C   1 
ATOM   2698 O O   . ASN B 2 144 ? -22.38671 6.37575   26.72059  1.000 46.73522  ? 138 ASN L O   1 
ATOM   2699 C CB  . ASN B 2 144 ? -23.67794 4.08156   26.02475  1.000 40.22364  ? 138 ASN L CB  1 
ATOM   2700 C CG  . ASN B 2 144 ? -24.29265 2.71904   25.74436  1.000 46.67871  ? 138 ASN L CG  1 
ATOM   2701 O OD1 . ASN B 2 144 ? -23.60522 1.70019   25.77263  1.000 47.21811  ? 138 ASN L OD1 1 
ATOM   2702 N ND2 . ASN B 2 144 ? -25.59237 2.69778   25.46485  1.000 50.79156  ? 138 ASN L ND2 1 
ATOM   2703 N N   . PHE B 2 145 ? -20.32849 5.48040   26.86341  1.000 42.15456  ? 139 PHE L N   1 
ATOM   2704 C CA  . PHE B 2 145 ? -19.67451 6.75603   27.12669  1.000 50.22043  ? 139 PHE L CA  1 
ATOM   2705 C C   . PHE B 2 145 ? -18.43664 6.90615   26.25067  1.000 51.37835  ? 139 PHE L C   1 
ATOM   2706 O O   . PHE B 2 145 ? -18.00236 5.96994   25.57595  1.000 51.78782  ? 139 PHE L O   1 
ATOM   2707 C CB  . PHE B 2 145 ? -19.29272 6.89965   28.60763  1.000 48.33270  ? 139 PHE L CB  1 
ATOM   2708 C CG  . PHE B 2 145 ? -18.25652 5.91275   29.07248  1.000 47.94328  ? 139 PHE L CG  1 
ATOM   2709 C CD1 . PHE B 2 145 ? -18.60600 4.61577   29.40328  1.000 49.13576  ? 139 PHE L CD1 1 
ATOM   2710 C CD2 . PHE B 2 145 ? -16.93489 6.28733   29.19298  1.000 46.34957  ? 139 PHE L CD2 1 
ATOM   2711 C CE1 . PHE B 2 145 ? -17.64982 3.71135   29.82627  1.000 41.39904  ? 139 PHE L CE1 1 
ATOM   2712 C CE2 . PHE B 2 145 ? -15.98362 5.38659   29.62054  1.000 43.21194  ? 139 PHE L CE2 1 
ATOM   2713 C CZ  . PHE B 2 145 ? -16.34254 4.10219   29.93918  1.000 38.71056  ? 139 PHE L CZ  1 
ATOM   2714 N N   . TYR B 2 146 ? -17.86373 8.11550   26.27852  1.000 55.43681  ? 140 TYR L N   1 
ATOM   2715 C CA  . TYR B 2 146 ? -16.66496 8.46091   25.52495  1.000 56.80755  ? 140 TYR L CA  1 
ATOM   2716 C C   . TYR B 2 146 ? -16.01935 9.66209   26.19166  1.000 54.77324  ? 140 TYR L C   1 
ATOM   2717 O O   . TYR B 2 146 ? -16.74035 10.59030  26.58644  1.000 56.71599  ? 140 TYR L O   1 
ATOM   2718 C CB  . TYR B 2 146 ? -16.99124 8.78062   24.05961  1.000 56.50408  ? 140 TYR L CB  1 
ATOM   2719 C CG  . TYR B 2 146 ? -15.77755 8.80011   23.15943  1.000 62.31515  ? 140 TYR L CG  1 
ATOM   2720 C CD1 . TYR B 2 146 ? -15.07625 9.97521   22.92805  1.000 61.20993  ? 140 TYR L CD1 1 
ATOM   2721 C CD2 . TYR B 2 146 ? -15.33042 7.63943   22.54297  1.000 63.37339  ? 140 TYR L CD2 1 
ATOM   2722 C CE1 . TYR B 2 146 ? -13.96352 9.99332   22.10697  1.000 59.85156  ? 140 TYR L CE1 1 
ATOM   2723 C CE2 . TYR B 2 146 ? -14.21565 7.64756   21.72461  1.000 66.16228  ? 140 TYR L CE2 1 
ATOM   2724 C CZ  . TYR B 2 146 ? -13.53437 8.82623   21.50848  1.000 61.70381  ? 140 TYR L CZ  1 
ATOM   2725 O OH  . TYR B 2 146 ? -12.42207 8.83018   20.68951  1.000 66.48961  ? 140 TYR L OH  1 
ATOM   2726 N N   . PRO B 2 147 ? -14.68636 9.69026   26.34148  1.000 51.32384  ? 141 PRO L N   1 
ATOM   2727 C CA  . PRO B 2 147 ? -13.74091 8.63952   25.95088  1.000 62.85764  ? 141 PRO L CA  1 
ATOM   2728 C C   . PRO B 2 147 ? -13.60887 7.52291   26.98660  1.000 62.42256  ? 141 PRO L C   1 
ATOM   2729 O O   . PRO B 2 147 ? -14.20313 7.59663   28.06077  1.000 61.38435  ? 141 PRO L O   1 
ATOM   2730 C CB  . PRO B 2 147 ? -12.42219 9.40198   25.82703  1.000 56.98542  ? 141 PRO L CB  1 
ATOM   2731 C CG  . PRO B 2 147 ? -12.53056 10.44172  26.88426  1.000 44.70604  ? 141 PRO L CG  1 
ATOM   2732 C CD  . PRO B 2 147 ? -13.98479 10.87718  26.86233  1.000 50.67671  ? 141 PRO L CD  1 
ATOM   2733 N N   . ARG B 2 148 ? -12.79853 6.51428   26.65914  1.000 61.32344  ? 142 ARG L N   1 
ATOM   2734 C CA  . ARG B 2 148 ? -12.61921 5.34565   27.51279  1.000 57.95965  ? 142 ARG L CA  1 
ATOM   2735 C C   . ARG B 2 148 ? -11.93324 5.67316   28.83604  1.000 67.09896  ? 142 ARG L C   1 
ATOM   2736 O O   . ARG B 2 148 ? -12.05816 4.90390   29.79480  1.000 60.94691  ? 142 ARG L O   1 
ATOM   2737 C CB  . ARG B 2 148 ? -11.81230 4.29438   26.75270  1.000 60.68437  ? 142 ARG L CB  1 
ATOM   2738 C CG  . ARG B 2 148 ? -11.69669 2.94447   27.41931  1.000 59.12883  ? 142 ARG L CG  1 
ATOM   2739 C CD  . ARG B 2 148 ? -11.09119 1.95791   26.44467  1.000 68.89183  ? 142 ARG L CD  1 
ATOM   2740 N NE  . ARG B 2 148 ? -9.74412  2.34509   26.04572  1.000 83.21721  ? 142 ARG L NE  1 
ATOM   2741 C CZ  . ARG B 2 148 ? -9.13885  1.92675   24.94176  1.000 92.98316  ? 142 ARG L CZ  1 
ATOM   2742 N NH1 . ARG B 2 148 ? -9.75478  1.14622   24.06834  1.000 72.40672  ? 142 ARG L NH1 1 
ATOM   2743 N NH2 . ARG B 2 148 ? -7.88432  2.30418   24.70640  1.000 107.99188 ? 142 ARG L NH2 1 
ATOM   2744 N N   . GLU B 2 149 ? -11.21414 6.78469   28.91920  1.000 60.00112  ? 143 GLU L N   1 
ATOM   2745 C CA  . GLU B 2 149 ? -10.46694 7.09122   30.13200  1.000 66.00072  ? 143 GLU L CA  1 
ATOM   2746 C C   . GLU B 2 149 ? -11.42609 7.50683   31.24545  1.000 58.78960  ? 143 GLU L C   1 
ATOM   2747 O O   . GLU B 2 149 ? -12.11386 8.52680   31.13622  1.000 61.38530  ? 143 GLU L O   1 
ATOM   2748 C CB  . GLU B 2 149 ? -9.43682  8.18982   29.85793  1.000 70.54053  ? 143 GLU L CB  1 
ATOM   2749 C CG  . GLU B 2 149 ? -8.23525  7.75596   29.00641  1.000 73.39762  ? 143 GLU L CG  1 
ATOM   2750 C CD  . GLU B 2 149 ? -8.57591  7.51697   27.53490  1.000 76.41052  ? 143 GLU L CD  1 
ATOM   2751 O OE1 . GLU B 2 149 ? -9.63307  7.98872   27.06048  1.000 67.46431  ? 143 GLU L OE1 1 
ATOM   2752 O OE2 . GLU B 2 149 ? -7.77699  6.84579   26.84929  1.000 93.58165  ? 143 GLU L OE2 1 
ATOM   2753 N N   . ALA B 2 150 ? -11.47663 6.71647   32.31385  1.000 45.02744  ? 144 ALA L N   1 
ATOM   2754 C CA  . ALA B 2 150 ? -12.27845 7.06667   33.47684  1.000 52.58462  ? 144 ALA L CA  1 
ATOM   2755 C C   . ALA B 2 150 ? -11.68992 6.38033   34.69869  1.000 47.10933  ? 144 ALA L C   1 
ATOM   2756 O O   . ALA B 2 150 ? -11.10857 5.29809   34.59254  1.000 43.84222  ? 144 ALA L O   1 
ATOM   2757 C CB  . ALA B 2 150 ? -13.74751 6.66585   33.29709  1.000 51.26419  ? 144 ALA L CB  1 
ATOM   2758 N N   . LYS B 2 151 ? -11.84060 7.02332   35.85664  1.000 46.48286  ? 145 LYS L N   1 
ATOM   2759 C CA  . LYS B 2 151 ? -11.43879 6.45395   37.14107  1.000 50.50408  ? 145 LYS L CA  1 
ATOM   2760 C C   . LYS B 2 151 ? -12.68662 6.03178   37.91295  1.000 53.97500  ? 145 LYS L C   1 
ATOM   2761 O O   . LYS B 2 151 ? -13.55142 6.86237   38.21264  1.000 48.13684  ? 145 LYS L O   1 
ATOM   2762 C CB  . LYS B 2 151 ? -10.61196 7.44825   37.96329  1.000 47.07160  ? 145 LYS L CB  1 
ATOM   2763 C CG  . LYS B 2 151 ? -10.06058 6.84221   39.25025  1.000 44.56201  ? 145 LYS L CG  1 
ATOM   2764 C CD  . LYS B 2 151 ? -9.22152  7.81003   40.06634  1.000 59.38462  ? 145 LYS L CD  1 
ATOM   2765 C CE  . LYS B 2 151 ? -10.06253 8.64853   41.01347  1.000 61.09516  ? 145 LYS L CE  1 
ATOM   2766 N NZ  . LYS B 2 151 ? -10.87346 9.66827   40.29879  1.000 74.27660  ? 145 LYS L NZ  1 
ATOM   2767 N N   . VAL B 2 152 ? -12.77567 4.74693   38.23220  1.000 51.96977  ? 146 VAL L N   1 
ATOM   2768 C CA  . VAL B 2 152 ? -13.89902 4.18719   38.97078  1.000 38.52033  ? 146 VAL L CA  1 
ATOM   2769 C C   . VAL B 2 152 ? -13.38397 3.74012   40.33436  1.000 48.13948  ? 146 VAL L C   1 
ATOM   2770 O O   . VAL B 2 152 ? -12.55039 2.82568   40.42497  1.000 37.74399  ? 146 VAL L O   1 
ATOM   2771 C CB  . VAL B 2 152 ? -14.54446 3.02849   38.19952  1.000 35.12654  ? 146 VAL L CB  1 
ATOM   2772 C CG1 . VAL B 2 152 ? -15.68247 2.42937   38.98777  1.000 51.88358  ? 146 VAL L CG1 1 
ATOM   2773 C CG2 . VAL B 2 152 ? -15.02738 3.50917   36.83255  1.000 40.59306  ? 146 VAL L CG2 1 
ATOM   2774 N N   . SER B 2 153 ? -13.87758 4.38921   41.38999  1.000 39.57107  ? 147 SER L N   1 
ATOM   2775 C CA  . SER B 2 153 ? -13.45211 4.14854   42.76433  1.000 47.64163  ? 147 SER L CA  1 
ATOM   2776 C C   . SER B 2 153 ? -14.58565 3.54015   43.59101  1.000 47.66546  ? 147 SER L C   1 
ATOM   2777 O O   . SER B 2 153 ? -15.75910 3.87518   43.41209  1.000 46.10222  ? 147 SER L O   1 
ATOM   2778 C CB  . SER B 2 153 ? -12.98297 5.45433   43.42982  1.000 49.39873  ? 147 SER L CB  1 
ATOM   2779 O OG  . SER B 2 153 ? -11.98787 6.12506   42.66328  1.000 45.70693  ? 147 SER L OG  1 
ATOM   2780 N N   . TRP B 2 154 ? -14.22728 2.66538   44.52582  1.000 51.26253  ? 148 TRP L N   1 
ATOM   2781 C CA  . TRP B 2 154 ? -15.18985 2.01380   45.40758  1.000 42.86782  ? 148 TRP L CA  1 
ATOM   2782 C C   . TRP B 2 154 ? -15.04172 2.51976   46.83648  1.000 51.61660  ? 148 TRP L C   1 
ATOM   2783 O O   . TRP B 2 154 ? -13.93444 2.53005   47.38711  1.000 50.87026  ? 148 TRP L O   1 
ATOM   2784 C CB  . TRP B 2 154 ? -15.00958 0.49710   45.40041  1.000 42.72443  ? 148 TRP L CB  1 
ATOM   2785 C CG  . TRP B 2 154 ? -15.53840 -0.20225  44.19719  1.000 47.47440  ? 148 TRP L CG  1 
ATOM   2786 C CD1 . TRP B 2 154 ? -14.80719 -0.73342  43.17171  1.000 46.93909  ? 148 TRP L CD1 1 
ATOM   2787 C CD2 . TRP B 2 154 ? -16.91220 -0.48371  43.89779  1.000 38.44791  ? 148 TRP L CD2 1 
ATOM   2788 N NE1 . TRP B 2 154 ? -15.64267 -1.32113  42.25088  1.000 42.47254  ? 148 TRP L NE1 1 
ATOM   2789 C CE2 . TRP B 2 154 ? -16.93856 -1.17992  42.67578  1.000 36.65987  ? 148 TRP L CE2 1 
ATOM   2790 C CE3 . TRP B 2 154 ? -18.12484 -0.20856  44.54162  1.000 50.02168  ? 148 TRP L CE3 1 
ATOM   2791 C CZ2 . TRP B 2 154 ? -18.12878 -1.60563  42.08729  1.000 43.35771  ? 148 TRP L CZ2 1 
ATOM   2792 C CZ3 . TRP B 2 154 ? -19.30847 -0.63620  43.95219  1.000 39.05493  ? 148 TRP L CZ3 1 
ATOM   2793 C CH2 . TRP B 2 154 ? -19.30012 -1.32215  42.74160  1.000 40.96136  ? 148 TRP L CH2 1 
ATOM   2794 N N   . TYR B 2 155 ? -16.16168 2.89697   47.44655  1.000 48.42642  ? 149 TYR L N   1 
ATOM   2795 C CA  . TYR B 2 155 ? -16.20626 3.27566   48.85279  1.000 45.62910  ? 149 TYR L CA  1 
ATOM   2796 C C   . TYR B 2 155 ? -17.14424 2.34433   49.60731  1.000 45.68738  ? 149 TYR L C   1 
ATOM   2797 O O   . TYR B 2 155 ? -18.29761 2.15131   49.20782  1.000 49.60829  ? 149 TYR L O   1 
ATOM   2798 C CB  . TYR B 2 155 ? -16.67350 4.72038   49.02969  1.000 53.33006  ? 149 TYR L CB  1 
ATOM   2799 C CG  . TYR B 2 155 ? -15.75080 5.74784   48.42824  1.000 51.39647  ? 149 TYR L CG  1 
ATOM   2800 C CD1 . TYR B 2 155 ? -15.78829 6.02796   47.06731  1.000 59.44242  ? 149 TYR L CD1 1 
ATOM   2801 C CD2 . TYR B 2 155 ? -14.85292 6.45199   49.22245  1.000 56.25801  ? 149 TYR L CD2 1 
ATOM   2802 C CE1 . TYR B 2 155 ? -14.94907 6.97061   46.51067  1.000 63.85266  ? 149 TYR L CE1 1 
ATOM   2803 C CE2 . TYR B 2 155 ? -14.01077 7.39661   48.68112  1.000 53.39994  ? 149 TYR L CE2 1 
ATOM   2804 C CZ  . TYR B 2 155 ? -14.05982 7.65335   47.32537  1.000 67.06063  ? 149 TYR L CZ  1 
ATOM   2805 O OH  . TYR B 2 155 ? -13.22152 8.59694   46.77945  1.000 63.49491  ? 149 TYR L OH  1 
ATOM   2806 N N   . VAL B 2 156 ? -16.65245 1.78308   50.70088  1.000 49.47736  ? 150 VAL L N   1 
ATOM   2807 C CA  . VAL B 2 156 ? -17.44481 0.96660   51.60886  1.000 51.51947  ? 150 VAL L CA  1 
ATOM   2808 C C   . VAL B 2 156 ? -17.52109 1.71515   52.92924  1.000 48.88971  ? 150 VAL L C   1 
ATOM   2809 O O   . VAL B 2 156 ? -16.50584 1.86186   53.62170  1.000 55.30241  ? 150 VAL L O   1 
ATOM   2810 C CB  . VAL B 2 156 ? -16.83996 -0.42694  51.80471  1.000 49.21407  ? 150 VAL L CB  1 
ATOM   2811 C CG1 . VAL B 2 156 ? -17.62868 -1.18876  52.85077  1.000 42.69792  ? 150 VAL L CG1 1 
ATOM   2812 C CG2 . VAL B 2 156 ? -16.80467 -1.18208  50.48099  1.000 41.41629  ? 150 VAL L CG2 1 
ATOM   2813 N N   . ASP B 2 157 ? -18.71664 2.18161   53.28641  1.000 45.25763  ? 151 ASP L N   1 
ATOM   2814 C CA  . ASP B 2 157 ? -18.88254 3.05363   54.45071  1.000 57.46055  ? 151 ASP L CA  1 
ATOM   2815 C C   . ASP B 2 157 ? -17.90141 4.22269   54.38343  1.000 56.58723  ? 151 ASP L C   1 
ATOM   2816 O O   . ASP B 2 157 ? -17.26994 4.59429   55.37414  1.000 64.75411  ? 151 ASP L O   1 
ATOM   2817 C CB  . ASP B 2 157 ? -18.71978 2.27924   55.76400  1.000 47.95786  ? 151 ASP L CB  1 
ATOM   2818 C CG  . ASP B 2 157 ? -19.99079 1.55836   56.19140  1.000 56.31036  ? 151 ASP L CG  1 
ATOM   2819 O OD1 . ASP B 2 157 ? -21.10156 1.98790   55.80932  1.000 46.71475  ? 151 ASP L OD1 1 
ATOM   2820 O OD2 . ASP B 2 157 ? -19.87162 0.56427   56.93624  1.000 54.63062  ? 151 ASP L OD2 1 
ATOM   2821 N N   . ASN B 2 158 ? -17.74569 4.77587   53.18290  1.000 56.69937  ? 152 ASN L N   1 
ATOM   2822 C CA  . ASN B 2 158 ? -16.96255 5.97191   52.89145  1.000 56.48471  ? 152 ASN L CA  1 
ATOM   2823 C C   . ASN B 2 158 ? -15.45966 5.74953   52.98104  1.000 46.95690  ? 152 ASN L C   1 
ATOM   2824 O O   . ASN B 2 158 ? -14.69257 6.70611   52.82203  1.000 55.20264  ? 152 ASN L O   1 
ATOM   2825 C CB  . ASN B 2 158 ? -17.38028 7.14046   53.78789  1.000 51.44409  ? 152 ASN L CB  1 
ATOM   2826 C CG  . ASN B 2 158 ? -18.79044 7.60436   53.49869  1.000 54.70991  ? 152 ASN L CG  1 
ATOM   2827 O OD1 . ASN B 2 158 ? -19.21086 7.65582   52.34064  1.000 66.51314  ? 152 ASN L OD1 1 
ATOM   2828 N ND2 . ASN B 2 158 ? -19.53671 7.93034   54.54796  1.000 58.69757  ? 152 ASN L ND2 1 
ATOM   2829 N N   . ALA B 2 159 ? -15.01370 4.51471   53.18669  1.000 50.57855  ? 153 ALA L N   1 
ATOM   2830 C CA  . ALA B 2 159 ? -13.59974 4.16808   53.14609  1.000 34.18554  ? 153 ALA L CA  1 
ATOM   2831 C C   . ALA B 2 159 ? -13.24732 3.69017   51.74446  1.000 55.49303  ? 153 ALA L C   1 
ATOM   2832 O O   . ALA B 2 159 ? -13.82150 2.70769   51.26416  1.000 52.32341  ? 153 ALA L O   1 
ATOM   2833 C CB  . ALA B 2 159 ? -13.27404 3.08430   54.16747  1.000 28.90035  ? 153 ALA L CB  1 
ATOM   2834 N N   . LEU B 2 160 ? -12.29042 4.36917   51.10628  1.000 60.42450  ? 154 LEU L N   1 
ATOM   2835 C CA  . LEU B 2 160 ? -11.87499 4.02647   49.75086  1.000 51.68528  ? 154 LEU L CA  1 
ATOM   2836 C C   . LEU B 2 160 ? -11.24453 2.63988   49.71535  1.000 49.21141  ? 154 LEU L C   1 
ATOM   2837 O O   . LEU B 2 160 ? -10.35674 2.33113   50.51262  1.000 57.23230  ? 154 LEU L O   1 
ATOM   2838 C CB  . LEU B 2 160 ? -10.88167 5.06310   49.23014  1.000 61.24862  ? 154 LEU L CB  1 
ATOM   2839 C CG  . LEU B 2 160 ? -10.35022 4.84568   47.81004  1.000 63.04513  ? 154 LEU L CG  1 
ATOM   2840 C CD1 . LEU B 2 160 ? -11.48779 4.85173   46.80538  1.000 57.81529  ? 154 LEU L CD1 1 
ATOM   2841 C CD2 . LEU B 2 160 ? -9.31785  5.90501   47.45073  1.000 71.87173  ? 154 LEU L CD2 1 
ATOM   2842 N N   . GLN B 2 161 ? -11.69588 1.80591   48.78571  1.000 51.43051  ? 155 GLN L N   1 
ATOM   2843 C CA  . GLN B 2 161 ? -11.17773 0.45206   48.65514  1.000 47.53514  ? 155 GLN L CA  1 
ATOM   2844 C C   . GLN B 2 161 ? -9.98729  0.42273   47.70751  1.000 59.17562  ? 155 GLN L C   1 
ATOM   2845 O O   . GLN B 2 161 ? -9.76199  1.34736   46.91891  1.000 55.72050  ? 155 GLN L O   1 
ATOM   2846 C CB  . GLN B 2 161 ? -12.25507 -0.50732  48.14100  1.000 51.68643  ? 155 GLN L CB  1 
ATOM   2847 C CG  . GLN B 2 161 ? -13.51978 -0.53212  48.96586  1.000 38.85888  ? 155 GLN L CG  1 
ATOM   2848 C CD  . GLN B 2 161 ? -13.27363 -0.99803  50.37961  1.000 40.61436  ? 155 GLN L CD  1 
ATOM   2849 O OE1 . GLN B 2 161 ? -12.97275 -2.17080  50.62557  1.000 42.54522  ? 155 GLN L OE1 1 
ATOM   2850 N NE2 . GLN B 2 161 ? -13.38857 -0.07506  51.32461  1.000 36.73752  ? 155 GLN L NE2 1 
ATOM   2851 N N   . SER B 2 162 ? -9.23965  -0.67902  47.77724  1.000 56.74234  ? 156 SER L N   1 
ATOM   2852 C CA  . SER B 2 162 ? -8.03160  -0.83643  46.98389  1.000 45.66017  ? 156 SER L CA  1 
ATOM   2853 C C   . SER B 2 162 ? -7.63058  -2.30036  46.96850  1.000 46.88236  ? 156 SER L C   1 
ATOM   2854 O O   . SER B 2 162 ? -7.62817  -2.95732  48.01150  1.000 52.94852  ? 156 SER L O   1 
ATOM   2855 C CB  . SER B 2 162 ? -6.90144  0.01649   47.55042  1.000 40.79998  ? 156 SER L CB  1 
ATOM   2856 O OG  . SER B 2 162 ? -5.75127  -0.10310  46.74076  1.000 74.38946  ? 156 SER L OG  1 
ATOM   2857 N N   . GLY B 2 163 ? -7.28934  -2.80050  45.79043  1.000 45.12668  ? 157 GLY L N   1 
ATOM   2858 C CA  . GLY B 2 163 ? -6.79693  -4.14777  45.64942  1.000 41.79075  ? 157 GLY L CA  1 
ATOM   2859 C C   . GLY B 2 163 ? -7.84985  -5.22487  45.55423  1.000 53.82366  ? 157 GLY L C   1 
ATOM   2860 O O   . GLY B 2 163 ? -7.48938  -6.39457  45.38327  1.000 55.39418  ? 157 GLY L O   1 
ATOM   2861 N N   . ASN B 2 164 ? -9.13655  -4.88270  45.64861  1.000 55.05067  ? 158 ASN L N   1 
ATOM   2862 C CA  . ASN B 2 164 ? -10.20201 -5.88199  45.65287  1.000 53.68598  ? 158 ASN L CA  1 
ATOM   2863 C C   . ASN B 2 164 ? -11.20031 -5.68319  44.51127  1.000 55.38777  ? 158 ASN L C   1 
ATOM   2864 O O   . ASN B 2 164 ? -12.33799 -6.15811  44.58361  1.000 49.15941  ? 158 ASN L O   1 
ATOM   2865 C CB  . ASN B 2 164 ? -10.92726 -5.90474  47.00297  1.000 45.16522  ? 158 ASN L CB  1 
ATOM   2866 C CG  . ASN B 2 164 ? -11.35728 -4.52357  47.47718  1.000 43.32085  ? 158 ASN L CG  1 
ATOM   2867 O OD1 . ASN B 2 164 ? -11.21481 -3.52679  46.76647  1.000 49.72561  ? 158 ASN L OD1 1 
ATOM   2868 N ND2 . ASN B 2 164 ? -11.89859 -4.46431  48.68912  1.000 50.90038  ? 158 ASN L ND2 1 
ATOM   2869 N N   . SER B 2 165 ? -10.78977 -5.00741  43.43918  1.000 55.05189  ? 159 SER L N   1 
ATOM   2870 C CA  . SER B 2 165 ? -11.68496 -4.71851  42.32722  1.000 52.56197  ? 159 SER L CA  1 
ATOM   2871 C C   . SER B 2 165 ? -10.99162 -5.02817  41.00694  1.000 52.83159  ? 159 SER L C   1 
ATOM   2872 O O   . SER B 2 165 ? -9.76520  -4.93757  40.90142  1.000 53.39739  ? 159 SER L O   1 
ATOM   2873 C CB  . SER B 2 165 ? -12.13538 -3.25549  42.35462  1.000 50.20580  ? 159 SER L CB  1 
ATOM   2874 O OG  . SER B 2 165 ? -11.02891 -2.38884  42.23367  1.000 52.33985  ? 159 SER L OG  1 
ATOM   2875 N N   . GLN B 2 166 ? -11.78963 -5.39608  39.99693  1.000 45.76675  ? 160 GLN L N   1 
ATOM   2876 C CA  . GLN B 2 166 ? -11.29218 -5.64444  38.64540  1.000 44.53671  ? 160 GLN L CA  1 
ATOM   2877 C C   . GLN B 2 166 ? -12.23574 -4.99699  37.64237  1.000 50.74075  ? 160 GLN L C   1 
ATOM   2878 O O   . GLN B 2 166 ? -13.45388 -5.00724  37.83812  1.000 59.09394  ? 160 GLN L O   1 
ATOM   2879 C CB  . GLN B 2 166 ? -11.15321 -7.15090  38.34066  1.000 39.56082  ? 160 GLN L CB  1 
ATOM   2880 C CG  . GLN B 2 166 ? -10.13890 -7.88245  39.23085  1.000 33.39297  ? 160 GLN L CG  1 
ATOM   2881 C CD  . GLN B 2 166 ? -9.88090  -9.32483  38.80272  1.000 33.89410  ? 160 GLN L CD  1 
ATOM   2882 O OE1 . GLN B 2 166 ? -10.63439 -10.23183 39.15112  1.000 48.76968  ? 160 GLN L OE1 1 
ATOM   2883 N NE2 . GLN B 2 166 ? -8.80843  -9.54067  38.04805  1.000 41.13865  ? 160 GLN L NE2 1 
ATOM   2884 N N   . GLU B 2 167 ? -11.67355 -4.43289  36.57245  1.000 47.17253  ? 161 GLU L N   1 
ATOM   2885 C CA  . GLU B 2 167 ? -12.43610 -3.70711  35.56274  1.000 36.47881  ? 161 GLU L CA  1 
ATOM   2886 C C   . GLU B 2 167 ? -12.43722 -4.46190  34.24197  1.000 40.08714  ? 161 GLU L C   1 
ATOM   2887 O O   . GLU B 2 167 ? -11.52849 -5.23759  33.94465  1.000 41.72044  ? 161 GLU L O   1 
ATOM   2888 C CB  . GLU B 2 167 ? -11.86876 -2.30059  35.32702  1.000 36.22292  ? 161 GLU L CB  1 
ATOM   2889 C CG  . GLU B 2 167 ? -12.03475 -1.33155  36.48534  1.000 41.00850  ? 161 GLU L CG  1 
ATOM   2890 C CD  . GLU B 2 167 ? -11.63395 0.08443   36.11064  1.000 55.22907  ? 161 GLU L CD  1 
ATOM   2891 O OE1 . GLU B 2 167 ? -11.36964 0.31800   34.90829  1.000 57.87111  ? 161 GLU L OE1 1 
ATOM   2892 O OE2 . GLU B 2 167 ? -11.57377 0.95803   37.01044  1.000 58.71085  ? 161 GLU L OE2 1 
ATOM   2893 N N   . SER B 2 168 ? -13.46792 -4.21858  33.43597  1.000 39.41318  ? 162 SER L N   1 
ATOM   2894 C CA  . SER B 2 168 ? -13.51943 -4.78253  32.09562  1.000 41.01685  ? 162 SER L CA  1 
ATOM   2895 C C   . SER B 2 168 ? -14.19646 -3.78026  31.17288  1.000 48.62042  ? 162 SER L C   1 
ATOM   2896 O O   . SER B 2 168 ? -15.17666 -3.14058  31.56063  1.000 50.54285  ? 162 SER L O   1 
ATOM   2897 C CB  . SER B 2 168 ? -14.25848 -6.12548  32.07605  1.000 36.77861  ? 162 SER L CB  1 
ATOM   2898 O OG  . SER B 2 168 ? -14.15343 -6.74799  30.80088  1.000 44.09307  ? 162 SER L OG  1 
ATOM   2899 N N   . VAL B 2 169 ? -13.66127 -3.63608  29.95731  1.000 57.13532  ? 163 VAL L N   1 
ATOM   2900 C CA  . VAL B 2 169 ? -14.17446 -2.67919  28.98263  1.000 48.49821  ? 163 VAL L CA  1 
ATOM   2901 C C   . VAL B 2 169 ? -14.45013 -3.39924  27.67190  1.000 56.34280  ? 163 VAL L C   1 
ATOM   2902 O O   . VAL B 2 169 ? -13.66004 -4.24808  27.24349  1.000 58.61910  ? 163 VAL L O   1 
ATOM   2903 C CB  . VAL B 2 169 ? -13.20347 -1.50483  28.74177  1.000 53.76397  ? 163 VAL L CB  1 
ATOM   2904 C CG1 . VAL B 2 169 ? -13.89529 -0.42276  27.92356  1.000 57.92906  ? 163 VAL L CG1 1 
ATOM   2905 C CG2 . VAL B 2 169 ? -12.69902 -0.94221  30.04979  1.000 64.71155  ? 163 VAL L CG2 1 
ATOM   2906 N N   . THR B 2 170 ? -15.57753 -3.05895  27.04265  1.000 53.23373  ? 164 THR L N   1 
ATOM   2907 C CA  . THR B 2 170 ? -15.93189 -3.51642  25.70755  1.000 51.08705  ? 164 THR L CA  1 
ATOM   2908 C C   . THR B 2 170 ? -15.16268 -2.72682  24.64954  1.000 54.52673  ? 164 THR L C   1 
ATOM   2909 O O   . THR B 2 170 ? -14.48108 -1.74038  24.94104  1.000 53.97687  ? 164 THR L O   1 
ATOM   2910 C CB  . THR B 2 170 ? -17.42772 -3.34907  25.45884  1.000 42.29096  ? 164 THR L CB  1 
ATOM   2911 O OG1 . THR B 2 170 ? -17.77233 -1.97060  25.61978  1.000 47.19925  ? 164 THR L OG1 1 
ATOM   2912 C CG2 . THR B 2 170 ? -18.24520 -4.17846  26.42846  1.000 49.38946  ? 164 THR L CG2 1 
ATOM   2913 N N   . GLU B 2 171 ? -15.28210 -3.17625  23.40293  1.000 55.62220  ? 165 GLU L N   1 
ATOM   2914 C CA  . GLU B 2 171 ? -14.78423 -2.41856  22.26685  1.000 60.55603  ? 165 GLU L CA  1 
ATOM   2915 C C   . GLU B 2 171 ? -15.77741 -1.31604  21.90195  1.000 60.28783  ? 165 GLU L C   1 
ATOM   2916 O O   . GLU B 2 171 ? -16.90984 -1.28051  22.39308  1.000 62.44857  ? 165 GLU L O   1 
ATOM   2917 C CB  . GLU B 2 171 ? -14.55686 -3.33691  21.06426  1.000 63.87429  ? 165 GLU L CB  1 
ATOM   2918 C CG  . GLU B 2 171 ? -13.70209 -4.57238  21.32493  1.000 66.43909  ? 165 GLU L CG  1 
ATOM   2919 C CD  . GLU B 2 171 ? -12.20612 -4.28665  21.31488  1.000 55.63050  ? 165 GLU L CD  1 
ATOM   2920 O OE1 . GLU B 2 171 ? -11.80469 -3.12235  21.51552  1.000 64.12721  ? 165 GLU L OE1 1 
ATOM   2921 O OE2 . GLU B 2 171 ? -11.42780 -5.23677  21.10020  1.000 66.96361  ? 165 GLU L OE2 1 
ATOM   2922 N N   . GLN B 2 172 ? -15.34140 -0.40751  21.02496  1.000 63.05596  ? 166 GLN L N   1 
ATOM   2923 C CA  . GLN B 2 172 ? -16.23073 0.63366   20.51810  1.000 58.18152  ? 166 GLN L CA  1 
ATOM   2924 C C   . GLN B 2 172 ? -17.44820 0.01682   19.84968  1.000 64.43559  ? 166 GLN L C   1 
ATOM   2925 O O   . GLN B 2 172 ? -17.31937 -0.84645  18.97585  1.000 71.42924  ? 166 GLN L O   1 
ATOM   2926 C CB  . GLN B 2 172 ? -15.50599 1.52676   19.51638  1.000 60.25728  ? 166 GLN L CB  1 
ATOM   2927 C CG  . GLN B 2 172 ? -14.77842 2.68824   20.12964  1.000 72.11137  ? 166 GLN L CG  1 
ATOM   2928 C CD  . GLN B 2 172 ? -14.53049 3.80084   19.13757  1.000 70.15480  ? 166 GLN L CD  1 
ATOM   2929 O OE1 . GLN B 2 172 ? -13.63161 3.71669   18.30039  1.000 69.73228  ? 166 GLN L OE1 1 
ATOM   2930 N NE2 . GLN B 2 172 ? -15.33648 4.85230   19.22094  1.000 66.45413  ? 166 GLN L NE2 1 
ATOM   2931 N N   . ASP B 2 173 ? -18.63392 0.45864   20.26211  1.000 58.07580  ? 167 ASP L N   1 
ATOM   2932 C CA  . ASP B 2 173 ? -19.84418 0.02082   19.58739  1.000 59.50418  ? 167 ASP L CA  1 
ATOM   2933 C C   . ASP B 2 173 ? -19.81924 0.49605   18.14133  1.000 67.36340  ? 167 ASP L C   1 
ATOM   2934 O O   . ASP B 2 173 ? -19.49663 1.65303   17.86149  1.000 62.23604  ? 167 ASP L O   1 
ATOM   2935 C CB  . ASP B 2 173 ? -21.07973 0.55419   20.30388  1.000 55.06684  ? 167 ASP L CB  1 
ATOM   2936 C CG  . ASP B 2 173 ? -22.34884 -0.11098  19.83143  1.000 57.94996  ? 167 ASP L CG  1 
ATOM   2937 O OD1 . ASP B 2 173 ? -22.26167 -1.08763  19.06334  1.000 68.01148  ? 167 ASP L OD1 1 
ATOM   2938 O OD2 . ASP B 2 173 ? -23.44094 0.33884   20.22220  1.000 86.18798  ? 167 ASP L OD2 1 
ATOM   2939 N N   . SER B 2 174 ? -20.13683 -0.41076  17.21597  1.000 76.51733  ? 168 SER L N   1 
ATOM   2940 C CA  . SER B 2 174 ? -20.08300 -0.06448  15.80086  1.000 73.13414  ? 168 SER L CA  1 
ATOM   2941 C C   . SER B 2 174 ? -21.12505 0.97813   15.42625  1.000 74.70975  ? 168 SER L C   1 
ATOM   2942 O O   . SER B 2 174 ? -20.99477 1.61611   14.37669  1.000 71.95093  ? 168 SER L O   1 
ATOM   2943 C CB  . SER B 2 174 ? -20.26433 -1.31811  14.94984  1.000 53.74642  ? 168 SER L CB  1 
ATOM   2944 O OG  . SER B 2 174 ? -21.44915 -1.99314  15.31690  1.000 71.44477  ? 168 SER L OG  1 
ATOM   2945 N N   . LYS B 2 175 ? -22.14585 1.17372   16.26203  1.000 66.97308  ? 169 LYS L N   1 
ATOM   2946 C CA  . LYS B 2 175 ? -23.19382 2.16084   15.97772  1.000 71.52461  ? 169 LYS L CA  1 
ATOM   2947 C C   . LYS B 2 175 ? -22.79243 3.53365   16.51658  1.000 79.81785  ? 169 LYS L C   1 
ATOM   2948 O O   . LYS B 2 175 ? -22.45237 4.43481   15.74565  1.000 81.19880  ? 169 LYS L O   1 
ATOM   2949 C CB  . LYS B 2 175 ? -24.53181 1.68387   16.54690  1.000 68.18338  ? 169 LYS L CB  1 
ATOM   2950 C CG  . LYS B 2 175 ? -25.70431 2.61609   16.28040  1.000 89.49913  ? 169 LYS L CG  1 
ATOM   2951 C CD  . LYS B 2 175 ? -26.97886 2.12741   16.97406  1.000 101.61011 ? 169 LYS L CD  1 
ATOM   2952 C CE  . LYS B 2 175 ? -28.16151 3.06173   16.71559  1.000 97.54651  ? 169 LYS L CE  1 
ATOM   2953 N NZ  . LYS B 2 175 ? -27.88961 4.45882   17.16691  1.000 99.82811  ? 169 LYS L NZ  1 
ATOM   2954 N N   . ASP B 2 176 ? -22.80028 3.69911   17.83875  1.000 72.06993  ? 170 ASP L N   1 
ATOM   2955 C CA  . ASP B 2 176 ? -22.60960 5.01556   18.43770  1.000 67.74810  ? 170 ASP L CA  1 
ATOM   2956 C C   . ASP B 2 176 ? -21.16901 5.31428   18.83451  1.000 63.33252  ? 170 ASP L C   1 
ATOM   2957 O O   . ASP B 2 176 ? -20.90517 6.40566   19.35102  1.000 69.12510  ? 170 ASP L O   1 
ATOM   2958 C CB  . ASP B 2 176 ? -23.52113 5.18172   19.65948  1.000 70.83323  ? 170 ASP L CB  1 
ATOM   2959 C CG  . ASP B 2 176 ? -23.58252 3.93760   20.51530  1.000 68.15120  ? 170 ASP L CG  1 
ATOM   2960 O OD1 . ASP B 2 176 ? -22.53906 3.54722   21.07260  1.000 58.41055  ? 170 ASP L OD1 1 
ATOM   2961 O OD2 . ASP B 2 176 ? -24.67750 3.34883   20.62598  1.000 79.69983  ? 170 ASP L OD2 1 
ATOM   2962 N N   . SER B 2 177 ? -20.23949 4.38050   18.61718  1.000 64.93286  ? 171 SER L N   1 
ATOM   2963 C CA  . SER B 2 177 ? -18.80991 4.58200   18.89509  1.000 63.14224  ? 171 SER L CA  1 
ATOM   2964 C C   . SER B 2 177 ? -18.51890 4.80473   20.38264  1.000 67.61794  ? 171 SER L C   1 
ATOM   2965 O O   . SER B 2 177 ? -17.53640 5.46301   20.74108  1.000 61.67038  ? 171 SER L O   1 
ATOM   2966 C CB  . SER B 2 177 ? -18.23410 5.73676   18.06494  1.000 66.26742  ? 171 SER L CB  1 
ATOM   2967 O OG  . SER B 2 177 ? -18.11116 5.38211   16.69600  1.000 73.82437  ? 171 SER L OG  1 
ATOM   2968 N N   . THR B 2 178 ? -19.33704 4.23621   21.26490  1.000 65.30743  ? 172 THR L N   1 
ATOM   2969 C CA  . THR B 2 178 ? -19.15975 4.40176   22.69951  1.000 59.49325  ? 172 THR L CA  1 
ATOM   2970 C C   . THR B 2 178 ? -18.64433 3.11704   23.33687  1.000 60.45280  ? 172 THR L C   1 
ATOM   2971 O O   . THR B 2 178 ? -18.74070 2.02424   22.76891  1.000 65.08390  ? 172 THR L O   1 
ATOM   2972 C CB  . THR B 2 178 ? -20.46853 4.82196   23.37818  1.000 54.50255  ? 172 THR L CB  1 
ATOM   2973 O OG1 . THR B 2 178 ? -21.40184 3.73364   23.34618  1.000 53.49564  ? 172 THR L OG1 1 
ATOM   2974 C CG2 . THR B 2 178 ? -21.07322 6.02749   22.67574  1.000 52.21655  ? 172 THR L CG2 1 
ATOM   2975 N N   . TYR B 2 179 ? -18.09167 3.27474   24.53618  1.000 56.34484  ? 173 TYR L N   1 
ATOM   2976 C CA  . TYR B 2 179 ? -17.57720 2.18456   25.34701  1.000 51.03591  ? 173 TYR L CA  1 
ATOM   2977 C C   . TYR B 2 179 ? -18.51044 1.91657   26.52207  1.000 55.59850  ? 173 TYR L C   1 
ATOM   2978 O O   . TYR B 2 179 ? -19.27900 2.78246   26.94818  1.000 52.67421  ? 173 TYR L O   1 
ATOM   2979 C CB  . TYR B 2 179 ? -16.17268 2.50574   25.87527  1.000 52.24240  ? 173 TYR L CB  1 
ATOM   2980 C CG  . TYR B 2 179 ? -15.13436 2.82943   24.81748  1.000 57.50625  ? 173 TYR L CG  1 
ATOM   2981 C CD1 . TYR B 2 179 ? -14.34807 1.83566   24.26647  1.000 58.96781  ? 173 TYR L CD1 1 
ATOM   2982 C CD2 . TYR B 2 179 ? -14.92666 4.13195   24.39166  1.000 62.96228  ? 173 TYR L CD2 1 
ATOM   2983 C CE1 . TYR B 2 179 ? -13.39827 2.12416   23.31030  1.000 69.44793  ? 173 TYR L CE1 1 
ATOM   2984 C CE2 . TYR B 2 179 ? -13.97934 4.42966   23.43026  1.000 56.57755  ? 173 TYR L CE2 1 
ATOM   2985 C CZ  . TYR B 2 179 ? -13.21423 3.42192   22.89703  1.000 67.01033  ? 173 TYR L CZ  1 
ATOM   2986 O OH  . TYR B 2 179 ? -12.26534 3.70339   21.94015  1.000 72.90237  ? 173 TYR L OH  1 
ATOM   2987 N N   . SER B 2 180 ? -18.43341 0.69695   27.04588  1.000 47.42368  ? 174 SER L N   1 
ATOM   2988 C CA  . SER B 2 180 ? -19.09143 0.34118   28.29301  1.000 43.86944  ? 174 SER L CA  1 
ATOM   2989 C C   . SER B 2 180 ? -18.07408 -0.32636  29.20744  1.000 54.55634  ? 174 SER L C   1 
ATOM   2990 O O   . SER B 2 180 ? -17.25808 -1.13828  28.75884  1.000 53.75519  ? 174 SER L O   1 
ATOM   2991 C CB  . SER B 2 180 ? -20.29776 -0.57995  28.06422  1.000 51.33939  ? 174 SER L CB  1 
ATOM   2992 O OG  . SER B 2 180 ? -21.36631 0.10767   27.43631  1.000 48.93636  ? 174 SER L OG  1 
ATOM   2993 N N   . LEU B 2 181 ? -18.11901 0.03092   30.48734  1.000 47.63227  ? 175 LEU L N   1 
ATOM   2994 C CA  . LEU B 2 181 ? -17.14473 -0.42221  31.46678  1.000 46.87461  ? 175 LEU L CA  1 
ATOM   2995 C C   . LEU B 2 181 ? -17.86889 -0.99714  32.67340  1.000 46.95223  ? 175 LEU L C   1 
ATOM   2996 O O   . LEU B 2 181 ? -18.93359 -0.50521  33.06136  1.000 56.84018  ? 175 LEU L O   1 
ATOM   2997 C CB  . LEU B 2 181 ? -16.22993 0.73543   31.89669  1.000 45.47929  ? 175 LEU L CB  1 
ATOM   2998 C CG  . LEU B 2 181 ? -14.98783 0.44106   32.73431  1.000 49.11085  ? 175 LEU L CG  1 
ATOM   2999 C CD1 . LEU B 2 181 ? -13.90075 1.43574   32.38347  1.000 51.42452  ? 175 LEU L CD1 1 
ATOM   3000 C CD2 . LEU B 2 181 ? -15.30479 0.51816   34.20654  1.000 40.02222  ? 175 LEU L CD2 1 
ATOM   3001 N N   . SER B 2 182 ? -17.28572 -2.03580  33.26554  1.000 47.23278  ? 176 SER L N   1 
ATOM   3002 C CA  . SER B 2 182 ? -17.80229 -2.63457  34.48688  1.000 43.57162  ? 176 SER L CA  1 
ATOM   3003 C C   . SER B 2 182 ? -16.67425 -2.77110  35.49237  1.000 43.88569  ? 176 SER L C   1 
ATOM   3004 O O   . SER B 2 182 ? -15.58218 -3.22113  35.14437  1.000 55.35802  ? 176 SER L O   1 
ATOM   3005 C CB  . SER B 2 182 ? -18.41652 -4.01474  34.22839  1.000 43.53364  ? 176 SER L CB  1 
ATOM   3006 O OG  . SER B 2 182 ? -17.40599 -4.99215  34.01963  1.000 40.44918  ? 176 SER L OG  1 
ATOM   3007 N N   . SER B 2 183 ? -16.94298 -2.39811  36.74030  1.000 54.54785  ? 177 SER L N   1 
ATOM   3008 C CA  . SER B 2 183 ? -15.99690 -2.56394  37.83853  1.000 48.30044  ? 177 SER L CA  1 
ATOM   3009 C C   . SER B 2 183 ? -16.61873 -3.49904  38.86484  1.000 49.37133  ? 177 SER L C   1 
ATOM   3010 O O   . SER B 2 183 ? -17.69775 -3.20956  39.38913  1.000 52.05382  ? 177 SER L O   1 
ATOM   3011 C CB  . SER B 2 183 ? -15.65799 -1.21931  38.48021  1.000 41.39345  ? 177 SER L CB  1 
ATOM   3012 O OG  . SER B 2 183 ? -14.63782 -1.36685  39.45312  1.000 46.72937  ? 177 SER L OG  1 
ATOM   3013 N N   . THR B 2 184 ? -15.94229 -4.60852  39.15821  1.000 46.03238  ? 178 THR L N   1 
ATOM   3014 C CA  . THR B 2 184 ? -16.45668 -5.62780  40.06503  1.000 34.65721  ? 178 THR L CA  1 
ATOM   3015 C C   . THR B 2 184 ? -15.63906 -5.62902  41.35064  1.000 44.80177  ? 178 THR L C   1 
ATOM   3016 O O   . THR B 2 184 ? -14.47875 -6.05730  41.36148  1.000 48.46820  ? 178 THR L O   1 
ATOM   3017 C CB  . THR B 2 184 ? -16.44830 -7.00452  39.40427  1.000 37.35118  ? 178 THR L CB  1 
ATOM   3018 O OG1 . THR B 2 184 ? -17.29561 -6.98205  38.25209  1.000 36.70072  ? 178 THR L OG1 1 
ATOM   3019 C CG2 . THR B 2 184 ? -16.97663 -8.05893  40.36106  1.000 47.66692  ? 178 THR L CG2 1 
ATOM   3020 N N   . LEU B 2 185 ? -16.25691 -5.15215  42.42964  1.000 46.10461  ? 179 LEU L N   1 
ATOM   3021 C CA  . LEU B 2 185 ? -15.68700 -5.20263  43.77019  1.000 37.07671  ? 179 LEU L CA  1 
ATOM   3022 C C   . LEU B 2 185 ? -16.01673 -6.54292  44.41241  1.000 37.15638  ? 179 LEU L C   1 
ATOM   3023 O O   . LEU B 2 185 ? -17.18929 -6.91468  44.50105  1.000 49.40530  ? 179 LEU L O   1 
ATOM   3024 C CB  . LEU B 2 185 ? -16.25032 -4.06928  44.62383  1.000 38.18935  ? 179 LEU L CB  1 
ATOM   3025 C CG  . LEU B 2 185 ? -15.77829 -3.98631  46.07343  1.000 50.01849  ? 179 LEU L CG  1 
ATOM   3026 C CD1 . LEU B 2 185 ? -14.37766 -3.39731  46.13650  1.000 37.13577  ? 179 LEU L CD1 1 
ATOM   3027 C CD2 . LEU B 2 185 ? -16.74750 -3.16716  46.91080  1.000 29.52931  ? 179 LEU L CD2 1 
ATOM   3028 N N   . THR B 2 186 ? -14.99392 -7.25830  44.87312  1.000 45.05112  ? 180 THR L N   1 
ATOM   3029 C CA  . THR B 2 186 ? -15.16352 -8.56278  45.51082  1.000 46.47147  ? 180 THR L CA  1 
ATOM   3030 C C   . THR B 2 186 ? -14.93695 -8.43467  47.01558  1.000 49.87863  ? 180 THR L C   1 
ATOM   3031 O O   . THR B 2 186 ? -13.83362 -8.08611  47.45400  1.000 49.55552  ? 180 THR L O   1 
ATOM   3032 C CB  . THR B 2 186 ? -14.20210 -9.59268  44.91623  1.000 42.86609  ? 180 THR L CB  1 
ATOM   3033 O OG1 . THR B 2 186 ? -14.60570 -9.90889  43.57730  1.000 52.35315  ? 180 THR L OG1 1 
ATOM   3034 C CG2 . THR B 2 186 ? -14.19932 -10.85626 45.75197  1.000 31.00216  ? 180 THR L CG2 1 
ATOM   3035 N N   . LEU B 2 187 ? -15.97706 -8.72132  47.80083  1.000 49.60972  ? 181 LEU L N   1 
ATOM   3036 C CA  . LEU B 2 187 ? -15.89874 -8.75424  49.25764  1.000 50.37475  ? 181 LEU L CA  1 
ATOM   3037 C C   . LEU B 2 187 ? -16.33737 -10.11259 49.78919  1.000 54.21647  ? 181 LEU L C   1 
ATOM   3038 O O   . LEU B 2 187 ? -17.07376 -10.85954 49.13230  1.000 45.44700  ? 181 LEU L O   1 
ATOM   3039 C CB  . LEU B 2 187 ? -16.77763 -7.67969  49.91607  1.000 43.99619  ? 181 LEU L CB  1 
ATOM   3040 C CG  . LEU B 2 187 ? -16.54358 -6.20411  49.62857  1.000 47.76038  ? 181 LEU L CG  1 
ATOM   3041 C CD1 . LEU B 2 187 ? -17.61648 -5.36961  50.32561  1.000 41.70695  ? 181 LEU L CD1 1 
ATOM   3042 C CD2 . LEU B 2 187 ? -15.15986 -5.79351  50.06585  1.000 42.43513  ? 181 LEU L CD2 1 
ATOM   3043 N N   . SER B 2 188 ? -15.87965 -10.41269 51.00333  1.000 46.85009  ? 182 SER L N   1 
ATOM   3044 C CA  . SER B 2 188 ? -16.36826 -11.56286 51.74472  1.000 49.39216  ? 182 SER L CA  1 
ATOM   3045 C C   . SER B 2 188 ? -17.76185 -11.27866 52.30387  1.000 51.70920  ? 182 SER L C   1 
ATOM   3046 O O   . SER B 2 188 ? -18.12005 -10.12959 52.58203  1.000 56.05314  ? 182 SER L O   1 
ATOM   3047 C CB  . SER B 2 188 ? -15.41314 -11.90514 52.88565  1.000 43.38655  ? 182 SER L CB  1 
ATOM   3048 O OG  . SER B 2 188 ? -15.48659 -10.92238 53.91315  1.000 53.88553  ? 182 SER L OG  1 
ATOM   3049 N N   . LYS B 2 189 ? -18.55119 -12.34785 52.47240  1.000 45.39234  ? 183 LYS L N   1 
ATOM   3050 C CA  . LYS B 2 189 ? -19.87936 -12.19347 53.06153  1.000 52.35205  ? 183 LYS L CA  1 
ATOM   3051 C C   . LYS B 2 189 ? -19.80661 -11.46201 54.39499  1.000 47.05471  ? 183 LYS L C   1 
ATOM   3052 O O   . LYS B 2 189 ? -20.62447 -10.57681 54.67203  1.000 50.54459  ? 183 LYS L O   1 
ATOM   3053 C CB  . LYS B 2 189 ? -20.54899 -13.55647 53.24031  1.000 51.65219  ? 183 LYS L CB  1 
ATOM   3054 C CG  . LYS B 2 189 ? -21.95609 -13.47201 53.83091  1.000 48.65893  ? 183 LYS L CG  1 
ATOM   3055 C CD  . LYS B 2 189 ? -22.48434 -14.84802 54.22115  1.000 46.57193  ? 183 LYS L CD  1 
ATOM   3056 C CE  . LYS B 2 189 ? -23.74777 -14.74044 55.05722  1.000 53.09362  ? 183 LYS L CE  1 
ATOM   3057 N NZ  . LYS B 2 189 ? -24.35740 -16.07059 55.29516  1.000 64.31838  ? 183 LYS L NZ  1 
ATOM   3058 N N   . ALA B 2 190 ? -18.81982 -11.80531 55.22453  1.000 46.16368  ? 184 ALA L N   1 
ATOM   3059 C CA  . ALA B 2 190 ? -18.67949 -11.15969 56.52525  1.000 47.64863  ? 184 ALA L CA  1 
ATOM   3060 C C   . ALA B 2 190 ? -18.45045 -9.66386  56.37410  1.000 53.67349  ? 184 ALA L C   1 
ATOM   3061 O O   . ALA B 2 190 ? -19.12490 -8.85123  57.01691  1.000 55.74669  ? 184 ALA L O   1 
ATOM   3062 C CB  . ALA B 2 190 ? -17.53111 -11.80129 57.29868  1.000 53.45476  ? 184 ALA L CB  1 
ATOM   3063 N N   . ASP B 2 191 ? -17.49258 -9.28282  55.52599  1.000 54.92977  ? 185 ASP L N   1 
ATOM   3064 C CA  . ASP B 2 191 ? -17.21521 -7.86808  55.30643  1.000 47.05693  ? 185 ASP L CA  1 
ATOM   3065 C C   . ASP B 2 191 ? -18.40914 -7.15854  54.69336  1.000 50.94192  ? 185 ASP L C   1 
ATOM   3066 O O   . ASP B 2 191 ? -18.69385 -6.00536  55.03478  1.000 53.22805  ? 185 ASP L O   1 
ATOM   3067 C CB  . ASP B 2 191 ? -15.98833 -7.70762  54.41491  1.000 58.97582  ? 185 ASP L CB  1 
ATOM   3068 C CG  . ASP B 2 191 ? -14.69741 -7.85174  55.18187  1.000 61.17651  ? 185 ASP L CG  1 
ATOM   3069 O OD1 . ASP B 2 191 ? -14.76366 -7.95279  56.42308  1.000 72.42956  ? 185 ASP L OD1 1 
ATOM   3070 O OD2 . ASP B 2 191 ? -13.62527 -7.86018  54.54808  1.000 65.01526  ? 185 ASP L OD2 1 
ATOM   3071 N N   . TYR B 2 192 ? -19.11722 -7.82923  53.77890  1.000 53.46601  ? 186 TYR L N   1 
ATOM   3072 C CA  . TYR B 2 192 ? -20.29517 -7.21901  53.17229  1.000 49.73918  ? 186 TYR L CA  1 
ATOM   3073 C C   . TYR B 2 192 ? -21.39498 -6.99488  54.19732  1.000 48.67896  ? 186 TYR L C   1 
ATOM   3074 O O   . TYR B 2 192 ? -22.09382 -5.97640  54.15242  1.000 44.58667  ? 186 TYR L O   1 
ATOM   3075 C CB  . TYR B 2 192 ? -20.82357 -8.07395  52.02212  1.000 44.43234  ? 186 TYR L CB  1 
ATOM   3076 C CG  . TYR B 2 192 ? -22.05445 -7.47166  51.39126  1.000 46.13835  ? 186 TYR L CG  1 
ATOM   3077 C CD1 . TYR B 2 192 ? -21.96046 -6.33528  50.59838  1.000 45.61626  ? 186 TYR L CD1 1 
ATOM   3078 C CD2 . TYR B 2 192 ? -23.31486 -8.02138  51.60118  1.000 44.46682  ? 186 TYR L CD2 1 
ATOM   3079 C CE1 . TYR B 2 192 ? -23.08254 -5.76618  50.02215  1.000 43.11275  ? 186 TYR L CE1 1 
ATOM   3080 C CE2 . TYR B 2 192 ? -24.44636 -7.45808  51.02478  1.000 42.14289  ? 186 TYR L CE2 1 
ATOM   3081 C CZ  . TYR B 2 192 ? -24.32404 -6.32888  50.23849  1.000 43.29751  ? 186 TYR L CZ  1 
ATOM   3082 O OH  . TYR B 2 192 ? -25.43694 -5.75751  49.65263  1.000 37.04362  ? 186 TYR L OH  1 
ATOM   3083 N N   . GLU B 2 193 ? -21.56879 -7.92521  55.12935  1.000 55.10080  ? 187 GLU L N   1 
ATOM   3084 C CA  . GLU B 2 193 ? -22.65420 -7.74856  56.08258  1.000 62.82748  ? 187 GLU L CA  1 
ATOM   3085 C C   . GLU B 2 193 ? -22.28351 -6.82884  57.24423  1.000 52.08199  ? 187 GLU L C   1 
ATOM   3086 O O   . GLU B 2 193 ? -23.18818 -6.33316  57.92224  1.000 53.62540  ? 187 GLU L O   1 
ATOM   3087 C CB  . GLU B 2 193 ? -23.14572 -9.12387  56.54874  1.000 50.68871  ? 187 GLU L CB  1 
ATOM   3088 C CG  . GLU B 2 193 ? -23.89855 -9.82514  55.40279  1.000 58.18650  ? 187 GLU L CG  1 
ATOM   3089 C CD  . GLU B 2 193 ? -24.38357 -11.23369 55.71097  1.000 68.36375  ? 187 GLU L CD  1 
ATOM   3090 O OE1 . GLU B 2 193 ? -23.74696 -11.92980 56.53150  1.000 67.67150  ? 187 GLU L OE1 1 
ATOM   3091 O OE2 . GLU B 2 193 ? -25.40773 -11.64232 55.11174  1.000 67.55825  ? 187 GLU L OE2 1 
ATOM   3092 N N   . LYS B 2 194 ? -20.99400 -6.51827  57.43550  1.000 54.34057  ? 188 LYS L N   1 
ATOM   3093 C CA  . LYS B 2 194 ? -20.60066 -5.55456  58.46178  1.000 47.15224  ? 188 LYS L CA  1 
ATOM   3094 C C   . LYS B 2 194 ? -20.95786 -4.11941  58.10092  1.000 53.73670  ? 188 LYS L C   1 
ATOM   3095 O O   . LYS B 2 194 ? -21.25255 -3.31766  58.99500  1.000 65.34470  ? 188 LYS L O   1 
ATOM   3096 C CB  . LYS B 2 194 ? -19.09962 -5.62309  58.72285  1.000 47.26342  ? 188 LYS L CB  1 
ATOM   3097 C CG  . LYS B 2 194 ? -18.64736 -6.87338  59.41346  1.000 59.14854  ? 188 LYS L CG  1 
ATOM   3098 C CD  . LYS B 2 194 ? -17.13841 -6.87460  59.61188  1.000 77.57927  ? 188 LYS L CD  1 
ATOM   3099 C CE  . LYS B 2 194 ? -16.69065 -8.16914  60.26799  1.000 87.01245  ? 188 LYS L CE  1 
ATOM   3100 N NZ  . LYS B 2 194 ? -15.23264 -8.18787  60.51266  1.000 87.80780  ? 188 LYS L NZ  1 
ATOM   3101 N N   . HIS B 2 195 ? -20.92716 -3.76902  56.82072  1.000 56.82093  ? 189 HIS L N   1 
ATOM   3102 C CA  . HIS B 2 195 ? -21.02698 -2.38150  56.39847  1.000 52.86137  ? 189 HIS L CA  1 
ATOM   3103 C C   . HIS B 2 195 ? -22.34820 -2.11229  55.69288  1.000 47.11550  ? 189 HIS L C   1 
ATOM   3104 O O   . HIS B 2 195 ? -23.01538 -3.02315  55.19721  1.000 45.31796  ? 189 HIS L O   1 
ATOM   3105 C CB  . HIS B 2 195 ? -19.85066 -2.02247  55.49258  1.000 51.16167  ? 189 HIS L CB  1 
ATOM   3106 C CG  . HIS B 2 195 ? -18.52163 -2.26449  56.13344  1.000 50.45611  ? 189 HIS L CG  1 
ATOM   3107 N ND1 . HIS B 2 195 ? -17.95956 -1.38967  57.04048  1.000 42.14760  ? 189 HIS L ND1 1 
ATOM   3108 C CD2 . HIS B 2 195 ? -17.65977 -3.30291  56.02680  1.000 52.03981  ? 189 HIS L CD2 1 
ATOM   3109 C CE1 . HIS B 2 195 ? -16.80029 -1.87263  57.45133  1.000 54.39137  ? 189 HIS L CE1 1 
ATOM   3110 N NE2 . HIS B 2 195 ? -16.59557 -3.03303  56.85291  1.000 55.41119  ? 189 HIS L NE2 1 
ATOM   3111 N N   . LYS B 2 196 ? -22.71583 -0.83367  55.65483  1.000 45.15468  ? 190 LYS L N   1 
ATOM   3112 C CA  . LYS B 2 196 ? -24.02093 -0.41494  55.17047  1.000 54.40704  ? 190 LYS L CA  1 
ATOM   3113 C C   . LYS B 2 196 ? -23.97843 0.28458   53.82007  1.000 58.51189  ? 190 LYS L C   1 
ATOM   3114 O O   . LYS B 2 196 ? -24.74382 -0.08248  52.92149  1.000 57.85147  ? 190 LYS L O   1 
ATOM   3115 C CB  . LYS B 2 196 ? -24.69157 0.49513   56.21082  1.000 55.50796  ? 190 LYS L CB  1 
ATOM   3116 C CG  . LYS B 2 196 ? -26.07668 0.97771   55.80685  1.000 62.89674  ? 190 LYS L CG  1 
ATOM   3117 C CD  . LYS B 2 196 ? -26.86640 1.40747   57.02471  1.000 70.67750  ? 190 LYS L CD  1 
ATOM   3118 C CE  . LYS B 2 196 ? -27.71860 2.62585   56.73354  1.000 84.95147  ? 190 LYS L CE  1 
ATOM   3119 N NZ  . LYS B 2 196 ? -28.50081 3.02922   57.93544  1.000 89.36279  ? 190 LYS L NZ  1 
ATOM   3120 N N   . VAL B 2 197 ? -23.11625 1.28813   53.64390  1.000 57.06670  ? 191 VAL L N   1 
ATOM   3121 C CA  . VAL B 2 197 ? -23.16020 2.13277   52.45278  1.000 52.06617  ? 191 VAL L CA  1 
ATOM   3122 C C   . VAL B 2 197 ? -22.11143 1.68372   51.44808  1.000 51.28053  ? 191 VAL L C   1 
ATOM   3123 O O   . VAL B 2 197 ? -20.92407 1.57426   51.77726  1.000 46.30135  ? 191 VAL L O   1 
ATOM   3124 C CB  . VAL B 2 197 ? -22.96464 3.61065   52.81061  1.000 47.88701  ? 191 VAL L CB  1 
ATOM   3125 C CG1 . VAL B 2 197 ? -23.21756 4.46481   51.57962  1.000 39.65357  ? 191 VAL L CG1 1 
ATOM   3126 C CG2 . VAL B 2 197 ? -23.89799 4.00910   53.94407  1.000 50.47939  ? 191 VAL L CG2 1 
ATOM   3127 N N   . TYR B 2 198 ? -22.55441 1.44803   50.21214  1.000 47.61546  ? 192 TYR L N   1 
ATOM   3128 C CA  . TYR B 2 198 ? -21.70079 0.98950   49.12323  1.000 52.48878  ? 192 TYR L CA  1 
ATOM   3129 C C   . TYR B 2 198 ? -21.82609 1.97328   47.97332  1.000 50.63102  ? 192 TYR L C   1 
ATOM   3130 O O   . TYR B 2 198 ? -22.93547 2.22368   47.49381  1.000 43.15503  ? 192 TYR L O   1 
ATOM   3131 C CB  . TYR B 2 198 ? -22.09170 -0.42712  48.69059  1.000 48.04060  ? 192 TYR L CB  1 
ATOM   3132 C CG  . TYR B 2 198 ? -21.78754 -1.43620  49.76746  1.000 49.60881  ? 192 TYR L CG  1 
ATOM   3133 C CD1 . TYR B 2 198 ? -22.65741 -1.63050  50.83521  1.000 57.71654  ? 192 TYR L CD1 1 
ATOM   3134 C CD2 . TYR B 2 198 ? -20.61501 -2.16188  49.74146  1.000 38.09717  ? 192 TYR L CD2 1 
ATOM   3135 C CE1 . TYR B 2 198 ? -22.36441 -2.53743  51.83801  1.000 52.72273  ? 192 TYR L CE1 1 
ATOM   3136 C CE2 . TYR B 2 198 ? -20.31663 -3.07038  50.72859  1.000 51.68934  ? 192 TYR L CE2 1 
ATOM   3137 C CZ  . TYR B 2 198 ? -21.18991 -3.25236  51.77695  1.000 49.36377  ? 192 TYR L CZ  1 
ATOM   3138 O OH  . TYR B 2 198 ? -20.88488 -4.15740  52.76244  1.000 58.68772  ? 192 TYR L OH  1 
ATOM   3139 N N   . ALA B 2 199 ? -20.69557 2.53526   47.53799  1.000 52.49965  ? 193 ALA L N   1 
ATOM   3140 C CA  . ALA B 2 199 ? -20.69625 3.59239   46.53892  1.000 40.01635  ? 193 ALA L CA  1 
ATOM   3141 C C   . ALA B 2 199 ? -19.72081 3.29692   45.41098  1.000 49.91702  ? 193 ALA L C   1 
ATOM   3142 O O   . ALA B 2 199 ? -18.68126 2.65402   45.59400  1.000 41.68707  ? 193 ALA L O   1 
ATOM   3143 C CB  . ALA B 2 199 ? -20.34633 4.94775   47.15664  1.000 42.26156  ? 193 ALA L CB  1 
ATOM   3144 N N   . CYS B 2 200 ? -20.07510 3.79824   44.23564  1.000 48.10132  ? 194 CYS L N   1 
ATOM   3145 C CA  A CYS B 2 200 ? -19.24204 3.73153   43.03648  0.874 38.49201  ? 194 CYS L CA  1 
ATOM   3146 C CA  B CYS B 2 200 ? -19.20825 3.74199   43.07436  0.126 39.16306  ? 194 CYS L CA  1 
ATOM   3147 C C   . CYS B 2 200 ? -19.04339 5.15479   42.54435  1.000 39.34295  ? 194 CYS L C   1 
ATOM   3148 O O   . CYS B 2 200 ? -20.02310 5.81888   42.20295  1.000 41.99595  ? 194 CYS L O   1 
ATOM   3149 C CB  A CYS B 2 200 ? -19.90485 2.88283   41.93764  0.874 42.01973  ? 194 CYS L CB  1 
ATOM   3150 C CB  B CYS B 2 200 ? -19.78146 2.81429   42.01367  0.126 42.04566  ? 194 CYS L CB  1 
ATOM   3151 S SG  A CYS B 2 200 ? -18.91180 2.67261   40.43290  0.874 51.67872  ? 194 CYS L SG  1 
ATOM   3152 S SG  B CYS B 2 200 ? -21.49510 3.15708   41.57321  0.126 42.74921  ? 194 CYS L SG  1 
ATOM   3153 N N   . GLU B 2 201 ? -17.80317 5.62923   42.51696  1.000 43.69964  ? 195 GLU L N   1 
ATOM   3154 C CA  . GLU B 2 201 ? -17.50772 6.96993   42.03047  1.000 37.55720  ? 195 GLU L CA  1 
ATOM   3155 C C   . GLU B 2 201 ? -16.85479 6.87669   40.65812  1.000 48.13673  ? 195 GLU L C   1 
ATOM   3156 O O   . GLU B 2 201 ? -15.82796 6.20796   40.49132  1.000 51.20947  ? 195 GLU L O   1 
ATOM   3157 C CB  . GLU B 2 201 ? -16.60971 7.72203   43.00058  1.000 41.26493  ? 195 GLU L CB  1 
ATOM   3158 C CG  . GLU B 2 201 ? -16.41335 9.17296   42.63316  1.000 39.39636  ? 195 GLU L CG  1 
ATOM   3159 C CD  . GLU B 2 201 ? -15.38108 9.82710   43.51718  1.000 49.58884  ? 195 GLU L CD  1 
ATOM   3160 O OE1 . GLU B 2 201 ? -14.37322 9.15085   43.81908  1.000 51.94666  ? 195 GLU L OE1 1 
ATOM   3161 O OE2 . GLU B 2 201 ? -15.58242 10.99270  43.92896  1.000 56.62127  ? 195 GLU L OE2 1 
ATOM   3162 N N   . VAL B 2 202 ? -17.45400 7.54674   39.68517  1.000 48.29400  ? 196 VAL L N   1 
ATOM   3163 C CA  . VAL B 2 202 ? -16.95457 7.58811   38.32343  1.000 49.95979  ? 196 VAL L CA  1 
ATOM   3164 C C   . VAL B 2 202 ? -16.45372 8.99733   38.07668  1.000 56.09328  ? 196 VAL L C   1 
ATOM   3165 O O   . VAL B 2 202 ? -17.21326 9.96173   38.23007  1.000 49.75903  ? 196 VAL L O   1 
ATOM   3166 C CB  . VAL B 2 202 ? -18.04364 7.20058   37.31868  1.000 36.84837  ? 196 VAL L CB  1 
ATOM   3167 C CG1 . VAL B 2 202 ? -17.52657 7.36541   35.90864  1.000 38.63658  ? 196 VAL L CG1 1 
ATOM   3168 C CG2 . VAL B 2 202 ? -18.48937 5.77369   37.57543  1.000 46.13301  ? 196 VAL L CG2 1 
ATOM   3169 N N   . THR B 2 203 ? -15.17567 9.12220   37.71656  1.000 46.82120  ? 197 THR L N   1 
ATOM   3170 C CA  . THR B 2 203 ? -14.55375 10.42050  37.48701  1.000 50.26303  ? 197 THR L CA  1 
ATOM   3171 C C   . THR B 2 203 ? -14.07664 10.51189  36.04323  1.000 54.80982  ? 197 THR L C   1 
ATOM   3172 O O   . THR B 2 203 ? -13.28484 9.67855   35.58867  1.000 54.13189  ? 197 THR L O   1 
ATOM   3173 C CB  . THR B 2 203 ? -13.39564 10.65625  38.45934  1.000 60.43058  ? 197 THR L CB  1 
ATOM   3174 O OG1 . THR B 2 203 ? -13.87627 10.53809  39.80770  1.000 50.99212  ? 197 THR L OG1 1 
ATOM   3175 C CG2 . THR B 2 203 ? -12.80190 12.04907  38.25237  1.000 50.68185  ? 197 THR L CG2 1 
ATOM   3176 N N   . GLN B 2 204 ? -14.58219 11.51151  35.32328  1.000 57.08629  ? 198 GLN L N   1 
ATOM   3177 C CA  . GLN B 2 204 ? -14.10745 11.87543  33.98773  1.000 52.93243  ? 198 GLN L CA  1 
ATOM   3178 C C   . GLN B 2 204 ? -13.88828 13.38559  33.96424  1.000 66.77730  ? 198 GLN L C   1 
ATOM   3179 O O   . GLN B 2 204 ? -14.85118 14.15795  33.98110  1.000 67.17716  ? 198 GLN L O   1 
ATOM   3180 C CB  . GLN B 2 204 ? -15.08809 11.45672  32.90731  1.000 50.56883  ? 198 GLN L CB  1 
ATOM   3181 C CG  . GLN B 2 204 ? -14.95978 10.02843  32.48562  1.000 50.02918  ? 198 GLN L CG  1 
ATOM   3182 C CD  . GLN B 2 204 ? -15.71005 9.75356   31.20721  1.000 63.12984  ? 198 GLN L CD  1 
ATOM   3183 O OE1 . GLN B 2 204 ? -16.73768 10.37760  30.92011  1.000 71.84191  ? 198 GLN L OE1 1 
ATOM   3184 N NE2 . GLN B 2 204 ? -15.19411 8.82428   30.41726  1.000 67.08115  ? 198 GLN L NE2 1 
ATOM   3185 N N   . GLY B 2 205 ? -12.62600 13.80234  33.93429  1.000 56.41875  ? 199 GLY L N   1 
ATOM   3186 C CA  . GLY B 2 205 ? -12.30043 15.20808  33.88328  1.000 45.48059  ? 199 GLY L CA  1 
ATOM   3187 C C   . GLY B 2 205 ? -12.74188 15.97909  35.10552  1.000 53.26130  ? 199 GLY L C   1 
ATOM   3188 O O   . GLY B 2 205 ? -12.25369 15.74999  36.21620  1.000 64.26797  ? 199 GLY L O   1 
ATOM   3189 N N   . THR B 2 206 ? -13.67807 16.89834  34.90875  1.000 55.27904  ? 200 THR L N   1 
ATOM   3190 C CA  . THR B 2 206 ? -14.15378 17.77093  35.96997  1.000 62.64848  ? 200 THR L CA  1 
ATOM   3191 C C   . THR B 2 206 ? -15.45900 17.29373  36.58828  1.000 62.52501  ? 200 THR L C   1 
ATOM   3192 O O   . THR B 2 206 ? -16.06703 18.03238  37.36678  1.000 66.51824  ? 200 THR L O   1 
ATOM   3193 C CB  . THR B 2 206 ? -14.33804 19.18874  35.43463  1.000 65.80082  ? 200 THR L CB  1 
ATOM   3194 O OG1 . THR B 2 206 ? -15.40625 19.19902  34.47400  1.000 64.93532  ? 200 THR L OG1 1 
ATOM   3195 C CG2 . THR B 2 206 ? -13.05787 19.65911  34.77455  1.000 47.31685  ? 200 THR L CG2 1 
ATOM   3196 N N   . THR B 2 207 ? -15.91408 16.09229  36.25345  1.000 59.27842  ? 201 THR L N   1 
ATOM   3197 C CA  . THR B 2 207 ? -17.18282 15.57725  36.74578  1.000 52.58017  ? 201 THR L CA  1 
ATOM   3198 C C   . THR B 2 207 ? -16.95004 14.24820  37.45060  1.000 56.33308  ? 201 THR L C   1 
ATOM   3199 O O   . THR B 2 207 ? -16.21435 13.38994  36.94866  1.000 52.12769  ? 201 THR L O   1 
ATOM   3200 C CB  . THR B 2 207 ? -18.18805 15.42279  35.60113  1.000 52.80729  ? 201 THR L CB  1 
ATOM   3201 O OG1 . THR B 2 207 ? -18.29512 16.66682  34.89714  1.000 67.41132  ? 201 THR L OG1 1 
ATOM   3202 C CG2 . THR B 2 207 ? -19.55715 15.05140  36.13719  1.000 65.56851  ? 201 THR L CG2 1 
ATOM   3203 N N   . SER B 2 208 ? -17.54631 14.10146  38.63073  1.000 53.11685  ? 202 SER L N   1 
ATOM   3204 C CA  . SER B 2 208 ? -17.58199 12.83796  39.35257  1.000 47.57501  ? 202 SER L CA  1 
ATOM   3205 C C   . SER B 2 208 ? -19.03594 12.49339  39.63989  1.000 46.79408  ? 202 SER L C   1 
ATOM   3206 O O   . SER B 2 208 ? -19.77924 13.33125  40.16070  1.000 46.73380  ? 202 SER L O   1 
ATOM   3207 C CB  . SER B 2 208 ? -16.77894 12.91005  40.65762  1.000 42.23029  ? 202 SER L CB  1 
ATOM   3208 O OG  . SER B 2 208 ? -15.38650 13.02620  40.40692  1.000 51.21220  ? 202 SER L OG  1 
ATOM   3209 N N   . VAL B 2 209 ? -19.44301 11.27338  39.28834  1.000 47.41619  ? 203 VAL L N   1 
ATOM   3210 C CA  . VAL B 2 209 ? -20.79277 10.77407  39.54350  1.000 44.86639  ? 203 VAL L CA  1 
ATOM   3211 C C   . VAL B 2 209 ? -20.69479 9.57273   40.47191  1.000 44.76376  ? 203 VAL L C   1 
ATOM   3212 O O   . VAL B 2 209 ? -19.99129 8.60285   40.16458  1.000 42.61776  ? 203 VAL L O   1 
ATOM   3213 C CB  . VAL B 2 209 ? -21.52800 10.38745  38.24515  1.000 36.61730  ? 203 VAL L CB  1 
ATOM   3214 C CG1 . VAL B 2 209 ? -22.86489 9.71779   38.57834  1.000 39.01093  ? 203 VAL L CG1 1 
ATOM   3215 C CG2 . VAL B 2 209 ? -21.75154 11.60723  37.37437  1.000 36.50319  ? 203 VAL L CG2 1 
ATOM   3216 N N   . THR B 2 210 ? -21.40891 9.63194   41.59521  1.000 41.22084  ? 204 THR L N   1 
ATOM   3217 C CA  . THR B 2 210 ? -21.41697 8.56252   42.58747  1.000 40.75856  ? 204 THR L CA  1 
ATOM   3218 C C   . THR B 2 210 ? -22.81755 7.96906   42.66806  1.000 38.65646  ? 204 THR L C   1 
ATOM   3219 O O   . THR B 2 210 ? -23.79454 8.70244   42.85756  1.000 42.62991  ? 204 THR L O   1 
ATOM   3220 C CB  . THR B 2 210 ? -20.96278 9.08224   43.95587  1.000 44.66064  ? 204 THR L CB  1 
ATOM   3221 O OG1 . THR B 2 210 ? -19.65082 9.64993   43.83551  1.000 49.25737  ? 204 THR L OG1 1 
ATOM   3222 C CG2 . THR B 2 210 ? -20.91851 7.95502   44.97876  1.000 36.76971  ? 204 THR L CG2 1 
ATOM   3223 N N   . LYS B 2 211 ? -22.91376 6.65094   42.49273  1.000 40.29308  ? 205 LYS L N   1 
ATOM   3224 C CA  . LYS B 2 211 ? -24.14913 5.89795   42.68168  1.000 46.38342  ? 205 LYS L CA  1 
ATOM   3225 C C   . LYS B 2 211 ? -23.94598 4.93969   43.84364  1.000 48.76160  ? 205 LYS L C   1 
ATOM   3226 O O   . LYS B 2 211 ? -22.94723 4.21632   43.88651  1.000 47.05366  ? 205 LYS L O   1 
ATOM   3227 C CB  . LYS B 2 211 ? -24.53861 5.12408   41.42208  1.000 36.02712  ? 205 LYS L CB  1 
ATOM   3228 C CG  . LYS B 2 211 ? -24.98250 5.99001   40.25630  1.000 38.69575  ? 205 LYS L CG  1 
ATOM   3229 C CD  . LYS B 2 211 ? -26.49600 6.19313   40.21118  1.000 46.41476  ? 205 LYS L CD  1 
ATOM   3230 C CE  . LYS B 2 211 ? -26.89033 6.94595   38.93721  1.000 54.89629  ? 205 LYS L CE  1 
ATOM   3231 N NZ  . LYS B 2 211 ? -28.35774 7.19647   38.79806  1.000 69.02760  ? 205 LYS L NZ  1 
ATOM   3232 N N   . SER B 2 212 ? -24.88198 4.93882   44.78682  1.000 46.95109  ? 206 SER L N   1 
ATOM   3233 C CA  . SER B 2 212 ? -24.71105 4.16186   46.00258  1.000 44.56342  ? 206 SER L CA  1 
ATOM   3234 C C   . SER B 2 212 ? -25.99589 3.41850   46.34020  1.000 43.25590  ? 206 SER L C   1 
ATOM   3235 O O   . SER B 2 212 ? -27.07302 3.70999   45.81739  1.000 46.30010  ? 206 SER L O   1 
ATOM   3236 C CB  . SER B 2 212 ? -24.28499 5.05604   47.17420  1.000 39.10662  ? 206 SER L CB  1 
ATOM   3237 O OG  . SER B 2 212 ? -24.89079 6.33590   47.06847  1.000 50.91722  ? 206 SER L OG  1 
ATOM   3238 N N   . PHE B 2 213 ? -25.85820 2.42748   47.21490  1.000 41.31548  ? 207 PHE L N   1 
ATOM   3239 C CA  . PHE B 2 213 ? -26.99349 1.77836   47.84384  1.000 41.37351  ? 207 PHE L CA  1 
ATOM   3240 C C   . PHE B 2 213 ? -26.62308 1.48075   49.28898  1.000 49.18764  ? 207 PHE L C   1 
ATOM   3241 O O   . PHE B 2 213 ? -25.44128 1.34716   49.62094  1.000 49.64948  ? 207 PHE L O   1 
ATOM   3242 C CB  . PHE B 2 213 ? -27.39057 0.49028   47.11147  1.000 30.36825  ? 207 PHE L CB  1 
ATOM   3243 C CG  . PHE B 2 213 ? -26.36102 -0.59724  47.19463  1.000 39.13975  ? 207 PHE L CG  1 
ATOM   3244 C CD1 . PHE B 2 213 ? -26.38217 -1.51546  48.22518  1.000 36.95339  ? 207 PHE L CD1 1 
ATOM   3245 C CD2 . PHE B 2 213 ? -25.37615 -0.70889  46.23384  1.000 38.94010  ? 207 PHE L CD2 1 
ATOM   3246 C CE1 . PHE B 2 213 ? -25.42769 -2.51558  48.30314  1.000 45.52836  ? 207 PHE L CE1 1 
ATOM   3247 C CE2 . PHE B 2 213 ? -24.42751 -1.71096  46.30628  1.000 40.49881  ? 207 PHE L CE2 1 
ATOM   3248 C CZ  . PHE B 2 213 ? -24.45334 -2.61290  47.34095  1.000 37.50889  ? 207 PHE L CZ  1 
ATOM   3249 N N   . ASN B 2 214 ? -27.64247 1.40024   50.14647  1.000 44.76977  ? 208 ASN L N   1 
ATOM   3250 C CA  . ASN B 2 214 ? -27.48658 0.93024   51.51993  1.000 48.76232  ? 208 ASN L CA  1 
ATOM   3251 C C   . ASN B 2 214 ? -27.85361 -0.54601  51.58381  1.000 52.70942  ? 208 ASN L C   1 
ATOM   3252 O O   . ASN B 2 214 ? -28.95721 -0.92689  51.17492  1.000 51.83032  ? 208 ASN L O   1 
ATOM   3253 C CB  . ASN B 2 214 ? -28.38090 1.71381   52.48327  1.000 55.40146  ? 208 ASN L CB  1 
ATOM   3254 C CG  . ASN B 2 214 ? -27.93547 3.14114   52.67570  1.000 61.35227  ? 208 ASN L CG  1 
ATOM   3255 O OD1 . ASN B 2 214 ? -26.99650 3.41162   53.41581  1.000 84.12882  ? 208 ASN L OD1 1 
ATOM   3256 N ND2 . ASN B 2 214 ? -28.63430 4.07033   52.04092  1.000 69.11743  ? 208 ASN L ND2 1 
ATOM   3257 N N   . ARG B 2 215 ? -26.93553 -1.37115  52.09567  1.000 40.16666  ? 209 ARG L N   1 
ATOM   3258 C CA  . ARG B 2 215 ? -27.20978 -2.79844  52.23343  1.000 43.99222  ? 209 ARG L CA  1 
ATOM   3259 C C   . ARG B 2 215 ? -28.51203 -3.02680  52.99523  1.000 54.59873  ? 209 ARG L C   1 
ATOM   3260 O O   . ARG B 2 215 ? -28.64223 -2.63514  54.15985  1.000 51.83561  ? 209 ARG L O   1 
ATOM   3261 C CB  . ARG B 2 215 ? -26.05906 -3.50961  52.94336  1.000 42.94802  ? 209 ARG L CB  1 
ATOM   3262 C CG  . ARG B 2 215 ? -26.32298 -5.00421  53.13772  1.000 49.65339  ? 209 ARG L CG  1 
ATOM   3263 C CD  . ARG B 2 215 ? -25.24070 -5.69886  53.94376  1.000 39.23036  ? 209 ARG L CD  1 
ATOM   3264 N NE  . ARG B 2 215 ? -24.86992 -4.94484  55.13439  1.000 56.93386  ? 209 ARG L NE  1 
ATOM   3265 C CZ  . ARG B 2 215 ? -25.49446 -5.01678  56.30315  1.000 64.34072  ? 209 ARG L CZ  1 
ATOM   3266 N NH1 . ARG B 2 215 ? -26.56078 -5.78359  56.47384  1.000 58.14957  ? 209 ARG L NH1 1 
ATOM   3267 N NH2 . ARG B 2 215 ? -25.03364 -4.30467  57.32833  1.000 56.69663  ? 209 ARG L NH2 1 
ATOM   3268 N N   . GLY B 2 216 ? -29.47944 -3.64855  52.32686  1.000 53.86326  ? 210 GLY L N   1 
ATOM   3269 C CA  . GLY B 2 216 ? -30.72267 -4.01171  52.96947  1.000 52.84499  ? 210 GLY L CA  1 
ATOM   3270 C C   . GLY B 2 216 ? -31.85725 -3.02905  52.81444  1.000 62.78513  ? 210 GLY L C   1 
ATOM   3271 O O   . GLY B 2 216 ? -32.80437 -3.07497  53.60525  1.000 68.50511  ? 210 GLY L O   1 
ATOM   3272 N N   . GLU B 2 217 ? -31.80416 -2.14508  51.82242  1.000 64.33244  ? 211 GLU L N   1 
ATOM   3273 C CA  . GLU B 2 217 ? -32.86045 -1.16728  51.60933  1.000 48.60203  ? 211 GLU L CA  1 
ATOM   3274 C C   . GLU B 2 217 ? -33.20226 -1.13031  50.12929  1.000 63.28149  ? 211 GLU L C   1 
ATOM   3275 O O   . GLU B 2 217 ? -32.30310 -1.10633  49.28268  1.000 68.74794  ? 211 GLU L O   1 
ATOM   3276 C CB  . GLU B 2 217 ? -32.43792 0.22064   52.11638  1.000 54.68173  ? 211 GLU L CB  1 
ATOM   3277 C CG  . GLU B 2 217 ? -31.91839 0.20289   53.56546  1.000 63.71163  ? 211 GLU L CG  1 
ATOM   3278 C CD  . GLU B 2 217 ? -31.42368 1.55584   54.05960  1.000 73.22865  ? 211 GLU L CD  1 
ATOM   3279 O OE1 . GLU B 2 217 ? -31.80160 2.58477   53.45599  1.000 77.31590  ? 211 GLU L OE1 1 
ATOM   3280 O OE2 . GLU B 2 217 ? -30.65033 1.58396   55.04805  1.000 66.28792  ? 211 GLU L OE2 1 
ATOM   3281 N N   . CYS B 2 218 ? -34.49978 -1.15620  49.82800  1.000 83.48672  ? 212 CYS L N   1 
ATOM   3282 C CA  . CYS B 2 218 ? -35.00030 -1.08359  48.45758  1.000 88.76375  ? 212 CYS L CA  1 
ATOM   3283 C C   . CYS B 2 218 ? -35.55788 0.30451   48.16432  1.000 86.80899  ? 212 CYS L C   1 
ATOM   3284 O O   . CYS B 2 218 ? -35.16405 0.94843   47.19063  1.000 80.86231  ? 212 CYS L O   1 
ATOM   3285 C CB  . CYS B 2 218 ? -36.07953 -2.14435  48.21429  1.000 86.65185  ? 212 CYS L CB  1 
ATOM   3286 S SG  . CYS B 2 218 ? -35.47508 -3.68609  47.48082  1.000 106.65504 ? 212 CYS L SG  1 
HETATM 3287 O O   . HOH C 3 .   ? -32.99386 4.95273   35.07139  1.000 59.25727  ? 301 HOH H O   1 
HETATM 3288 O O   . HOH C 3 .   ? -34.56884 -18.20763 27.41272  1.000 41.16802  ? 302 HOH H O   1 
HETATM 3289 O O   . HOH C 3 .   ? -21.24704 -6.95551  23.77832  1.000 40.33683  ? 303 HOH H O   1 
HETATM 3290 O O   . HOH C 3 .   ? -3.30102  -22.50739 33.71349  1.000 57.38057  ? 304 HOH H O   1 
HETATM 3291 O O   . HOH D 3 .   ? -17.57910 -7.54913  33.93130  1.000 46.97962  ? 301 HOH L O   1 
HETATM 3292 O O   . HOH D 3 .   ? -14.82960 -4.48769  58.08712  1.000 54.89806  ? 302 HOH L O   1 
HETATM 3293 O O   . HOH D 3 .   ? -19.67796 12.21157  42.99093  1.000 44.30336  ? 303 HOH L O   1 
HETATM 3294 O O   . HOH D 3 .   ? -18.06906 -8.78768  36.33330  1.000 29.44353  ? 304 HOH L O   1 
HETATM 3295 O O   . HOH D 3 .   ? -16.55464 -5.66992  23.37315  1.000 45.36105  ? 305 HOH L O   1 
HETATM 3296 O O   . HOH D 3 .   ? -14.60240 16.13127  40.34391  1.000 36.65246  ? 306 HOH L O   1 
# 
