data_8UA3
# 
_entry.id   8UA3 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.400 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8UA3         pdb_00008ua3 10.2210/pdb8ua3/pdb 
WWPDB D_1000277643 ?            ?                   
EMDB  EMD-42049    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-13 
3 'Structure model' 1 2 2024-11-20 
4 'Structure model' 1 3 2025-01-08 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
3 3 'Structure model' 'Data collection'     
4 3 'Structure model' 'Database references' 
5 4 'Structure model' 'Data collection'     
6 4 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
4 3 'Structure model' citation        
5 3 'Structure model' em_admin        
6 4 'Structure model' citation        
7 4 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.journal_abbrev'          
2  2 'Structure model' '_citation.journal_id_ASTM'         
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.pdbx_database_id_DOI'    
6  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_em_admin.last_update'             
9  3 'Structure model' '_citation.country'                 
10 3 'Structure model' '_citation.journal_abbrev'          
11 3 'Structure model' '_citation.journal_id_ASTM'         
12 3 'Structure model' '_citation.journal_id_CSD'          
13 3 'Structure model' '_citation.journal_id_ISSN'         
14 3 'Structure model' '_citation.pdbx_database_id_PubMed' 
15 3 'Structure model' '_citation.title'                   
16 3 'Structure model' '_em_admin.last_update'             
17 4 'Structure model' '_citation.journal_volume'          
18 4 'Structure model' '_citation.page_first'              
19 4 'Structure model' '_citation.page_last'               
20 4 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8UA3 
_pdbx_database_status.recvd_initial_deposition_date   2023-09-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM Structure of FBOX22-BACH1BTB' 
_pdbx_database_related.db_id          EMD-42049 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              nzheng@uw.edu 
_pdbx_contact_author.name_first         Zheng 
_pdbx_contact_author.name_last          Ning 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1039-1581 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Shi, H.'   1 0000-0003-2428-2500 
'Cao, S.'   2 0000-0003-1201-4963 
'Zheng, N.' 3 0000-0002-1039-1581 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Cell 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1097-4172 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            187 
_citation.language                  ? 
_citation.page_first                7568 
_citation.page_last                 7584.e22 
_citation.title                     
'Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cell.2024.10.012 
_citation.pdbx_database_id_PubMed   39504958 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Cao, S.'        1  ? 
primary 'Garcia, S.F.'   2  ? 
primary 'Shi, H.'        3  ? 
primary 'James, E.I.'    4  ? 
primary 'Kito, Y.'       5  ? 
primary 'Shi, H.'        6  ? 
primary 'Mao, H.'        7  ? 
primary 'Kaisari, S.'    8  ? 
primary 'Rona, G.'       9  ? 
primary 'Deng, S.'       10 ? 
primary 'Goldberg, H.V.' 11 ? 
primary 'Ponce, J.'      12 ? 
primary 'Ueberheide, B.' 13 ? 
primary 'Lignitto, L.'   14 ? 
primary 'Guttman, M.'    15 ? 
primary 'Pagano, M.'     16 ? 
primary 'Zheng, N.'      17 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'F-box only protein 22'                 44562.270 1 ? ? ?                                 ? 
2 polymer man 'Transcription regulator protein BACH1' 13839.761 2 ? ? 'BTB domain (UNP residues 7-128)' ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MEPVGCCGECRGSSVDPRSTFVLSNLAEVVERVLTFLPAKALLRVACVCRLWRECVRRVLRTHRSVTWISAGLAEAGHLE
GHCLVRVVAEELENVRILPHTVLYMADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGS
GSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVV
STFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTI
GFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLG
SSK
;
;MEPVGCCGECRGSSVDPRSTFVLSNLAEVVERVLTFLPAKALLRVACVCRLWRECVRRVLRTHRSVTWISAGLAEAGHLE
GHCLVRVVAEELENVRILPHTVLYMADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGS
GSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVV
STFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTI
GFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLG
SSK
;
C   ? 
2 'polypeptide(L)' no no 
;SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKF
;
;SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKF
;
D,E ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLU n 
1 3   PRO n 
1 4   VAL n 
1 5   GLY n 
1 6   CYS n 
1 7   CYS n 
1 8   GLY n 
1 9   GLU n 
1 10  CYS n 
1 11  ARG n 
1 12  GLY n 
1 13  SER n 
1 14  SER n 
1 15  VAL n 
1 16  ASP n 
1 17  PRO n 
1 18  ARG n 
1 19  SER n 
1 20  THR n 
1 21  PHE n 
1 22  VAL n 
1 23  LEU n 
1 24  SER n 
1 25  ASN n 
1 26  LEU n 
1 27  ALA n 
1 28  GLU n 
1 29  VAL n 
1 30  VAL n 
1 31  GLU n 
1 32  ARG n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  PHE n 
1 37  LEU n 
1 38  PRO n 
1 39  ALA n 
1 40  LYS n 
1 41  ALA n 
1 42  LEU n 
1 43  LEU n 
1 44  ARG n 
1 45  VAL n 
1 46  ALA n 
1 47  CYS n 
1 48  VAL n 
1 49  CYS n 
1 50  ARG n 
1 51  LEU n 
1 52  TRP n 
1 53  ARG n 
1 54  GLU n 
1 55  CYS n 
1 56  VAL n 
1 57  ARG n 
1 58  ARG n 
1 59  VAL n 
1 60  LEU n 
1 61  ARG n 
1 62  THR n 
1 63  HIS n 
1 64  ARG n 
1 65  SER n 
1 66  VAL n 
1 67  THR n 
1 68  TRP n 
1 69  ILE n 
1 70  SER n 
1 71  ALA n 
1 72  GLY n 
1 73  LEU n 
1 74  ALA n 
1 75  GLU n 
1 76  ALA n 
1 77  GLY n 
1 78  HIS n 
1 79  LEU n 
1 80  GLU n 
1 81  GLY n 
1 82  HIS n 
1 83  CYS n 
1 84  LEU n 
1 85  VAL n 
1 86  ARG n 
1 87  VAL n 
1 88  VAL n 
1 89  ALA n 
1 90  GLU n 
1 91  GLU n 
1 92  LEU n 
1 93  GLU n 
1 94  ASN n 
1 95  VAL n 
1 96  ARG n 
1 97  ILE n 
1 98  LEU n 
1 99  PRO n 
1 100 HIS n 
1 101 THR n 
1 102 VAL n 
1 103 LEU n 
1 104 TYR n 
1 105 MET n 
1 106 ALA n 
1 107 ASP n 
1 108 SER n 
1 109 GLU n 
1 110 THR n 
1 111 PHE n 
1 112 ILE n 
1 113 SER n 
1 114 LEU n 
1 115 GLU n 
1 116 GLU n 
1 117 CYS n 
1 118 ARG n 
1 119 GLY n 
1 120 HIS n 
1 121 LYS n 
1 122 ARG n 
1 123 ALA n 
1 124 ARG n 
1 125 LYS n 
1 126 ARG n 
1 127 THR n 
1 128 SER n 
1 129 MET n 
1 130 GLU n 
1 131 THR n 
1 132 ALA n 
1 133 LEU n 
1 134 ALA n 
1 135 LEU n 
1 136 GLU n 
1 137 LYS n 
1 138 LEU n 
1 139 PHE n 
1 140 PRO n 
1 141 LYS n 
1 142 GLN n 
1 143 CYS n 
1 144 GLN n 
1 145 VAL n 
1 146 LEU n 
1 147 GLY n 
1 148 ILE n 
1 149 VAL n 
1 150 THR n 
1 151 PRO n 
1 152 GLY n 
1 153 ILE n 
1 154 VAL n 
1 155 VAL n 
1 156 THR n 
1 157 PRO n 
1 158 MET n 
1 159 GLY n 
1 160 SER n 
1 161 GLY n 
1 162 SER n 
1 163 ASN n 
1 164 ARG n 
1 165 PRO n 
1 166 GLN n 
1 167 GLU n 
1 168 ILE n 
1 169 GLU n 
1 170 ILE n 
1 171 GLY n 
1 172 GLU n 
1 173 SER n 
1 174 GLY n 
1 175 PHE n 
1 176 ALA n 
1 177 LEU n 
1 178 LEU n 
1 179 PHE n 
1 180 PRO n 
1 181 GLN n 
1 182 ILE n 
1 183 GLU n 
1 184 GLY n 
1 185 ILE n 
1 186 LYS n 
1 187 ILE n 
1 188 GLN n 
1 189 PRO n 
1 190 PHE n 
1 191 HIS n 
1 192 PHE n 
1 193 ILE n 
1 194 LYS n 
1 195 ASP n 
1 196 PRO n 
1 197 LYS n 
1 198 ASN n 
1 199 LEU n 
1 200 THR n 
1 201 LEU n 
1 202 GLU n 
1 203 ARG n 
1 204 HIS n 
1 205 GLN n 
1 206 LEU n 
1 207 THR n 
1 208 GLU n 
1 209 VAL n 
1 210 GLY n 
1 211 LEU n 
1 212 LEU n 
1 213 ASP n 
1 214 ASN n 
1 215 PRO n 
1 216 GLU n 
1 217 LEU n 
1 218 ARG n 
1 219 VAL n 
1 220 VAL n 
1 221 LEU n 
1 222 VAL n 
1 223 PHE n 
1 224 GLY n 
1 225 TYR n 
1 226 ASN n 
1 227 CYS n 
1 228 CYS n 
1 229 LYS n 
1 230 VAL n 
1 231 GLY n 
1 232 ALA n 
1 233 SER n 
1 234 ASN n 
1 235 TYR n 
1 236 LEU n 
1 237 GLN n 
1 238 GLN n 
1 239 VAL n 
1 240 VAL n 
1 241 SER n 
1 242 THR n 
1 243 PHE n 
1 244 SER n 
1 245 ASP n 
1 246 MET n 
1 247 ASN n 
1 248 ILE n 
1 249 ILE n 
1 250 LEU n 
1 251 ALA n 
1 252 GLY n 
1 253 GLY n 
1 254 GLN n 
1 255 VAL n 
1 256 ASP n 
1 257 ASN n 
1 258 LEU n 
1 259 SER n 
1 260 SER n 
1 261 LEU n 
1 262 THR n 
1 263 SER n 
1 264 GLU n 
1 265 LYS n 
1 266 ASN n 
1 267 PRO n 
1 268 LEU n 
1 269 ASP n 
1 270 ILE n 
1 271 ASP n 
1 272 ALA n 
1 273 SER n 
1 274 GLY n 
1 275 VAL n 
1 276 VAL n 
1 277 GLY n 
1 278 LEU n 
1 279 SER n 
1 280 PHE n 
1 281 SER n 
1 282 GLY n 
1 283 HIS n 
1 284 ARG n 
1 285 ILE n 
1 286 GLN n 
1 287 SER n 
1 288 ALA n 
1 289 THR n 
1 290 VAL n 
1 291 LEU n 
1 292 LEU n 
1 293 ASN n 
1 294 GLU n 
1 295 ASP n 
1 296 VAL n 
1 297 SER n 
1 298 ASP n 
1 299 GLU n 
1 300 LYS n 
1 301 THR n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ALA n 
1 306 MET n 
1 307 GLN n 
1 308 ARG n 
1 309 LEU n 
1 310 LYS n 
1 311 ALA n 
1 312 ALA n 
1 313 ASN n 
1 314 ILE n 
1 315 PRO n 
1 316 GLU n 
1 317 HIS n 
1 318 ASN n 
1 319 THR n 
1 320 ILE n 
1 321 GLY n 
1 322 PHE n 
1 323 MET n 
1 324 PHE n 
1 325 ALA n 
1 326 CYS n 
1 327 VAL n 
1 328 GLY n 
1 329 ARG n 
1 330 GLY n 
1 331 PHE n 
1 332 GLN n 
1 333 TYR n 
1 334 TYR n 
1 335 ARG n 
1 336 ALA n 
1 337 LYS n 
1 338 GLY n 
1 339 ASN n 
1 340 VAL n 
1 341 GLU n 
1 342 ALA n 
1 343 ASP n 
1 344 ALA n 
1 345 PHE n 
1 346 ARG n 
1 347 LYS n 
1 348 PHE n 
1 349 PHE n 
1 350 PRO n 
1 351 SER n 
1 352 VAL n 
1 353 PRO n 
1 354 LEU n 
1 355 PHE n 
1 356 GLY n 
1 357 PHE n 
1 358 PHE n 
1 359 GLY n 
1 360 ASN n 
1 361 GLY n 
1 362 GLU n 
1 363 ILE n 
1 364 GLY n 
1 365 CYS n 
1 366 ASP n 
1 367 ARG n 
1 368 ILE n 
1 369 VAL n 
1 370 THR n 
1 371 GLY n 
1 372 ASN n 
1 373 PHE n 
1 374 ILE n 
1 375 LEU n 
1 376 ARG n 
1 377 LYS n 
1 378 CYS n 
1 379 ASN n 
1 380 GLU n 
1 381 VAL n 
1 382 LYS n 
1 383 ASP n 
1 384 ASP n 
1 385 ASP n 
1 386 LEU n 
1 387 PHE n 
1 388 HIS n 
1 389 SER n 
1 390 TYR n 
1 391 THR n 
1 392 THR n 
1 393 ILE n 
1 394 MET n 
1 395 ALA n 
1 396 LEU n 
1 397 ILE n 
1 398 HIS n 
1 399 LEU n 
1 400 GLY n 
1 401 SER n 
1 402 SER n 
1 403 LYS n 
2 1   SER n 
2 2   VAL n 
2 3   PHE n 
2 4   ALA n 
2 5   TYR n 
2 6   GLU n 
2 7   SER n 
2 8   SER n 
2 9   VAL n 
2 10  HIS n 
2 11  SER n 
2 12  THR n 
2 13  ASN n 
2 14  VAL n 
2 15  LEU n 
2 16  LEU n 
2 17  SER n 
2 18  LEU n 
2 19  ASN n 
2 20  ASP n 
2 21  GLN n 
2 22  ARG n 
2 23  LYS n 
2 24  LYS n 
2 25  ASP n 
2 26  VAL n 
2 27  LEU n 
2 28  CYS n 
2 29  ASP n 
2 30  VAL n 
2 31  THR n 
2 32  ILE n 
2 33  PHE n 
2 34  VAL n 
2 35  GLU n 
2 36  GLY n 
2 37  GLN n 
2 38  ARG n 
2 39  PHE n 
2 40  ARG n 
2 41  ALA n 
2 42  HIS n 
2 43  ARG n 
2 44  SER n 
2 45  VAL n 
2 46  LEU n 
2 47  ALA n 
2 48  ALA n 
2 49  CYS n 
2 50  SER n 
2 51  SER n 
2 52  TYR n 
2 53  PHE n 
2 54  HIS n 
2 55  SER n 
2 56  ARG n 
2 57  ILE n 
2 58  VAL n 
2 59  GLY n 
2 60  GLN n 
2 61  ALA n 
2 62  ASP n 
2 63  GLY n 
2 64  GLU n 
2 65  LEU n 
2 66  ASN n 
2 67  ILE n 
2 68  THR n 
2 69  LEU n 
2 70  PRO n 
2 71  GLU n 
2 72  GLU n 
2 73  VAL n 
2 74  THR n 
2 75  VAL n 
2 76  LYS n 
2 77  GLY n 
2 78  PHE n 
2 79  GLU n 
2 80  PRO n 
2 81  LEU n 
2 82  ILE n 
2 83  GLN n 
2 84  PHE n 
2 85  ALA n 
2 86  TYR n 
2 87  THR n 
2 88  ALA n 
2 89  LYS n 
2 90  LEU n 
2 91  ILE n 
2 92  LEU n 
2 93  SER n 
2 94  LYS n 
2 95  GLU n 
2 96  ASN n 
2 97  VAL n 
2 98  ASP n 
2 99  GLU n 
2 100 VAL n 
2 101 CYS n 
2 102 LYS n 
2 103 CYS n 
2 104 VAL n 
2 105 GLU n 
2 106 PHE n 
2 107 LEU n 
2 108 SER n 
2 109 VAL n 
2 110 HIS n 
2 111 ASN n 
2 112 ILE n 
2 113 GLU n 
2 114 GLU n 
2 115 SER n 
2 116 CYS n 
2 117 PHE n 
2 118 GLN n 
2 119 PHE n 
2 120 LEU n 
2 121 LYS n 
2 122 PHE n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 403 human ? FBXO22 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? 'cabbage looper' 
'Trichoplusia ni'  7111 ? ? ? ? ? ? ? ? 'High Five' ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 122 human ? BACH1  ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?                
'Escherichia coli' 562  ? ? ? ? ? ? ? ? ?           ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   C . n 
A 1 2   GLU 2   2   ?   ?   ?   C . n 
A 1 3   PRO 3   3   ?   ?   ?   C . n 
A 1 4   VAL 4   4   ?   ?   ?   C . n 
A 1 5   GLY 5   5   ?   ?   ?   C . n 
A 1 6   CYS 6   6   ?   ?   ?   C . n 
A 1 7   CYS 7   7   ?   ?   ?   C . n 
A 1 8   GLY 8   8   ?   ?   ?   C . n 
A 1 9   GLU 9   9   ?   ?   ?   C . n 
A 1 10  CYS 10  10  ?   ?   ?   C . n 
A 1 11  ARG 11  11  ?   ?   ?   C . n 
A 1 12  GLY 12  12  ?   ?   ?   C . n 
A 1 13  SER 13  13  ?   ?   ?   C . n 
A 1 14  SER 14  14  ?   ?   ?   C . n 
A 1 15  VAL 15  15  ?   ?   ?   C . n 
A 1 16  ASP 16  16  ?   ?   ?   C . n 
A 1 17  PRO 17  17  ?   ?   ?   C . n 
A 1 18  ARG 18  18  ?   ?   ?   C . n 
A 1 19  SER 19  19  ?   ?   ?   C . n 
A 1 20  THR 20  20  ?   ?   ?   C . n 
A 1 21  PHE 21  21  ?   ?   ?   C . n 
A 1 22  VAL 22  22  ?   ?   ?   C . n 
A 1 23  LEU 23  23  ?   ?   ?   C . n 
A 1 24  SER 24  24  ?   ?   ?   C . n 
A 1 25  ASN 25  25  ?   ?   ?   C . n 
A 1 26  LEU 26  26  ?   ?   ?   C . n 
A 1 27  ALA 27  27  ?   ?   ?   C . n 
A 1 28  GLU 28  28  ?   ?   ?   C . n 
A 1 29  VAL 29  29  ?   ?   ?   C . n 
A 1 30  VAL 30  30  ?   ?   ?   C . n 
A 1 31  GLU 31  31  ?   ?   ?   C . n 
A 1 32  ARG 32  32  ?   ?   ?   C . n 
A 1 33  VAL 33  33  ?   ?   ?   C . n 
A 1 34  LEU 34  34  ?   ?   ?   C . n 
A 1 35  THR 35  35  ?   ?   ?   C . n 
A 1 36  PHE 36  36  ?   ?   ?   C . n 
A 1 37  LEU 37  37  ?   ?   ?   C . n 
A 1 38  PRO 38  38  ?   ?   ?   C . n 
A 1 39  ALA 39  39  ?   ?   ?   C . n 
A 1 40  LYS 40  40  ?   ?   ?   C . n 
A 1 41  ALA 41  41  ?   ?   ?   C . n 
A 1 42  LEU 42  42  ?   ?   ?   C . n 
A 1 43  LEU 43  43  ?   ?   ?   C . n 
A 1 44  ARG 44  44  ?   ?   ?   C . n 
A 1 45  VAL 45  45  ?   ?   ?   C . n 
A 1 46  ALA 46  46  ?   ?   ?   C . n 
A 1 47  CYS 47  47  ?   ?   ?   C . n 
A 1 48  VAL 48  48  ?   ?   ?   C . n 
A 1 49  CYS 49  49  ?   ?   ?   C . n 
A 1 50  ARG 50  50  ?   ?   ?   C . n 
A 1 51  LEU 51  51  ?   ?   ?   C . n 
A 1 52  TRP 52  52  ?   ?   ?   C . n 
A 1 53  ARG 53  53  ?   ?   ?   C . n 
A 1 54  GLU 54  54  ?   ?   ?   C . n 
A 1 55  CYS 55  55  ?   ?   ?   C . n 
A 1 56  VAL 56  56  ?   ?   ?   C . n 
A 1 57  ARG 57  57  ?   ?   ?   C . n 
A 1 58  ARG 58  58  ?   ?   ?   C . n 
A 1 59  VAL 59  59  ?   ?   ?   C . n 
A 1 60  LEU 60  60  ?   ?   ?   C . n 
A 1 61  ARG 61  61  ?   ?   ?   C . n 
A 1 62  THR 62  62  ?   ?   ?   C . n 
A 1 63  HIS 63  63  ?   ?   ?   C . n 
A 1 64  ARG 64  64  ?   ?   ?   C . n 
A 1 65  SER 65  65  65  SER SER C . n 
A 1 66  VAL 66  66  66  VAL VAL C . n 
A 1 67  THR 67  67  67  THR THR C . n 
A 1 68  TRP 68  68  68  TRP TRP C . n 
A 1 69  ILE 69  69  69  ILE ILE C . n 
A 1 70  SER 70  70  70  SER SER C . n 
A 1 71  ALA 71  71  71  ALA ALA C . n 
A 1 72  GLY 72  72  72  GLY GLY C . n 
A 1 73  LEU 73  73  73  LEU LEU C . n 
A 1 74  ALA 74  74  74  ALA ALA C . n 
A 1 75  GLU 75  75  75  GLU GLU C . n 
A 1 76  ALA 76  76  76  ALA ALA C . n 
A 1 77  GLY 77  77  77  GLY GLY C . n 
A 1 78  HIS 78  78  78  HIS HIS C . n 
A 1 79  LEU 79  79  79  LEU LEU C . n 
A 1 80  GLU 80  80  80  GLU GLU C . n 
A 1 81  GLY 81  81  81  GLY GLY C . n 
A 1 82  HIS 82  82  82  HIS HIS C . n 
A 1 83  CYS 83  83  83  CYS CYS C . n 
A 1 84  LEU 84  84  84  LEU LEU C . n 
A 1 85  VAL 85  85  85  VAL VAL C . n 
A 1 86  ARG 86  86  86  ARG ARG C . n 
A 1 87  VAL 87  87  87  VAL VAL C . n 
A 1 88  VAL 88  88  88  VAL VAL C . n 
A 1 89  ALA 89  89  89  ALA ALA C . n 
A 1 90  GLU 90  90  90  GLU GLU C . n 
A 1 91  GLU 91  91  91  GLU GLU C . n 
A 1 92  LEU 92  92  92  LEU LEU C . n 
A 1 93  GLU 93  93  93  GLU GLU C . n 
A 1 94  ASN 94  94  94  ASN ASN C . n 
A 1 95  VAL 95  95  95  VAL VAL C . n 
A 1 96  ARG 96  96  96  ARG ARG C . n 
A 1 97  ILE 97  97  97  ILE ILE C . n 
A 1 98  LEU 98  98  98  LEU LEU C . n 
A 1 99  PRO 99  99  99  PRO PRO C . n 
A 1 100 HIS 100 100 100 HIS HIS C . n 
A 1 101 THR 101 101 101 THR THR C . n 
A 1 102 VAL 102 102 102 VAL VAL C . n 
A 1 103 LEU 103 103 103 LEU LEU C . n 
A 1 104 TYR 104 104 104 TYR TYR C . n 
A 1 105 MET 105 105 105 MET MET C . n 
A 1 106 ALA 106 106 106 ALA ALA C . n 
A 1 107 ASP 107 107 107 ASP ASP C . n 
A 1 108 SER 108 108 108 SER SER C . n 
A 1 109 GLU 109 109 109 GLU GLU C . n 
A 1 110 THR 110 110 110 THR THR C . n 
A 1 111 PHE 111 111 111 PHE PHE C . n 
A 1 112 ILE 112 112 112 ILE ILE C . n 
A 1 113 SER 113 113 113 SER SER C . n 
A 1 114 LEU 114 114 114 LEU LEU C . n 
A 1 115 GLU 115 115 115 GLU GLU C . n 
A 1 116 GLU 116 116 116 GLU GLU C . n 
A 1 117 CYS 117 117 ?   ?   ?   C . n 
A 1 118 ARG 118 118 ?   ?   ?   C . n 
A 1 119 GLY 119 119 ?   ?   ?   C . n 
A 1 120 HIS 120 120 ?   ?   ?   C . n 
A 1 121 LYS 121 121 ?   ?   ?   C . n 
A 1 122 ARG 122 122 ?   ?   ?   C . n 
A 1 123 ALA 123 123 ?   ?   ?   C . n 
A 1 124 ARG 124 124 ?   ?   ?   C . n 
A 1 125 LYS 125 125 ?   ?   ?   C . n 
A 1 126 ARG 126 126 ?   ?   ?   C . n 
A 1 127 THR 127 127 127 THR THR C . n 
A 1 128 SER 128 128 128 SER SER C . n 
A 1 129 MET 129 129 129 MET MET C . n 
A 1 130 GLU 130 130 130 GLU GLU C . n 
A 1 131 THR 131 131 131 THR THR C . n 
A 1 132 ALA 132 132 132 ALA ALA C . n 
A 1 133 LEU 133 133 133 LEU LEU C . n 
A 1 134 ALA 134 134 134 ALA ALA C . n 
A 1 135 LEU 135 135 135 LEU LEU C . n 
A 1 136 GLU 136 136 136 GLU GLU C . n 
A 1 137 LYS 137 137 137 LYS LYS C . n 
A 1 138 LEU 138 138 138 LEU LEU C . n 
A 1 139 PHE 139 139 139 PHE PHE C . n 
A 1 140 PRO 140 140 140 PRO PRO C . n 
A 1 141 LYS 141 141 141 LYS LYS C . n 
A 1 142 GLN 142 142 142 GLN GLN C . n 
A 1 143 CYS 143 143 143 CYS CYS C . n 
A 1 144 GLN 144 144 144 GLN GLN C . n 
A 1 145 VAL 145 145 145 VAL VAL C . n 
A 1 146 LEU 146 146 146 LEU LEU C . n 
A 1 147 GLY 147 147 147 GLY GLY C . n 
A 1 148 ILE 148 148 148 ILE ILE C . n 
A 1 149 VAL 149 149 149 VAL VAL C . n 
A 1 150 THR 150 150 150 THR THR C . n 
A 1 151 PRO 151 151 151 PRO PRO C . n 
A 1 152 GLY 152 152 152 GLY GLY C . n 
A 1 153 ILE 153 153 153 ILE ILE C . n 
A 1 154 VAL 154 154 154 VAL VAL C . n 
A 1 155 VAL 155 155 155 VAL VAL C . n 
A 1 156 THR 156 156 156 THR THR C . n 
A 1 157 PRO 157 157 157 PRO PRO C . n 
A 1 158 MET 158 158 158 MET MET C . n 
A 1 159 GLY 159 159 159 GLY GLY C . n 
A 1 160 SER 160 160 160 SER SER C . n 
A 1 161 GLY 161 161 161 GLY GLY C . n 
A 1 162 SER 162 162 162 SER SER C . n 
A 1 163 ASN 163 163 163 ASN ASN C . n 
A 1 164 ARG 164 164 164 ARG ARG C . n 
A 1 165 PRO 165 165 165 PRO PRO C . n 
A 1 166 GLN 166 166 166 GLN GLN C . n 
A 1 167 GLU 167 167 167 GLU GLU C . n 
A 1 168 ILE 168 168 168 ILE ILE C . n 
A 1 169 GLU 169 169 169 GLU GLU C . n 
A 1 170 ILE 170 170 170 ILE ILE C . n 
A 1 171 GLY 171 171 171 GLY GLY C . n 
A 1 172 GLU 172 172 172 GLU GLU C . n 
A 1 173 SER 173 173 173 SER SER C . n 
A 1 174 GLY 174 174 174 GLY GLY C . n 
A 1 175 PHE 175 175 175 PHE PHE C . n 
A 1 176 ALA 176 176 176 ALA ALA C . n 
A 1 177 LEU 177 177 177 LEU LEU C . n 
A 1 178 LEU 178 178 178 LEU LEU C . n 
A 1 179 PHE 179 179 179 PHE PHE C . n 
A 1 180 PRO 180 180 180 PRO PRO C . n 
A 1 181 GLN 181 181 181 GLN GLN C . n 
A 1 182 ILE 182 182 182 ILE ILE C . n 
A 1 183 GLU 183 183 183 GLU GLU C . n 
A 1 184 GLY 184 184 184 GLY GLY C . n 
A 1 185 ILE 185 185 185 ILE ILE C . n 
A 1 186 LYS 186 186 186 LYS LYS C . n 
A 1 187 ILE 187 187 187 ILE ILE C . n 
A 1 188 GLN 188 188 188 GLN GLN C . n 
A 1 189 PRO 189 189 189 PRO PRO C . n 
A 1 190 PHE 190 190 190 PHE PHE C . n 
A 1 191 HIS 191 191 191 HIS HIS C . n 
A 1 192 PHE 192 192 192 PHE PHE C . n 
A 1 193 ILE 193 193 193 ILE ILE C . n 
A 1 194 LYS 194 194 194 LYS LYS C . n 
A 1 195 ASP 195 195 195 ASP ASP C . n 
A 1 196 PRO 196 196 196 PRO PRO C . n 
A 1 197 LYS 197 197 197 LYS LYS C . n 
A 1 198 ASN 198 198 198 ASN ASN C . n 
A 1 199 LEU 199 199 199 LEU LEU C . n 
A 1 200 THR 200 200 200 THR THR C . n 
A 1 201 LEU 201 201 201 LEU LEU C . n 
A 1 202 GLU 202 202 202 GLU GLU C . n 
A 1 203 ARG 203 203 203 ARG ARG C . n 
A 1 204 HIS 204 204 204 HIS HIS C . n 
A 1 205 GLN 205 205 205 GLN GLN C . n 
A 1 206 LEU 206 206 206 LEU LEU C . n 
A 1 207 THR 207 207 207 THR THR C . n 
A 1 208 GLU 208 208 208 GLU GLU C . n 
A 1 209 VAL 209 209 209 VAL VAL C . n 
A 1 210 GLY 210 210 210 GLY GLY C . n 
A 1 211 LEU 211 211 211 LEU LEU C . n 
A 1 212 LEU 212 212 212 LEU LEU C . n 
A 1 213 ASP 213 213 213 ASP ASP C . n 
A 1 214 ASN 214 214 214 ASN ASN C . n 
A 1 215 PRO 215 215 215 PRO PRO C . n 
A 1 216 GLU 216 216 216 GLU GLU C . n 
A 1 217 LEU 217 217 217 LEU LEU C . n 
A 1 218 ARG 218 218 218 ARG ARG C . n 
A 1 219 VAL 219 219 219 VAL VAL C . n 
A 1 220 VAL 220 220 220 VAL VAL C . n 
A 1 221 LEU 221 221 221 LEU LEU C . n 
A 1 222 VAL 222 222 222 VAL VAL C . n 
A 1 223 PHE 223 223 223 PHE PHE C . n 
A 1 224 GLY 224 224 224 GLY GLY C . n 
A 1 225 TYR 225 225 225 TYR TYR C . n 
A 1 226 ASN 226 226 226 ASN ASN C . n 
A 1 227 CYS 227 227 227 CYS CYS C . n 
A 1 228 CYS 228 228 228 CYS CYS C . n 
A 1 229 LYS 229 229 229 LYS LYS C . n 
A 1 230 VAL 230 230 230 VAL VAL C . n 
A 1 231 GLY 231 231 231 GLY GLY C . n 
A 1 232 ALA 232 232 232 ALA ALA C . n 
A 1 233 SER 233 233 233 SER SER C . n 
A 1 234 ASN 234 234 234 ASN ASN C . n 
A 1 235 TYR 235 235 235 TYR TYR C . n 
A 1 236 LEU 236 236 236 LEU LEU C . n 
A 1 237 GLN 237 237 237 GLN GLN C . n 
A 1 238 GLN 238 238 238 GLN GLN C . n 
A 1 239 VAL 239 239 239 VAL VAL C . n 
A 1 240 VAL 240 240 240 VAL VAL C . n 
A 1 241 SER 241 241 241 SER SER C . n 
A 1 242 THR 242 242 242 THR THR C . n 
A 1 243 PHE 243 243 243 PHE PHE C . n 
A 1 244 SER 244 244 244 SER SER C . n 
A 1 245 ASP 245 245 245 ASP ASP C . n 
A 1 246 MET 246 246 246 MET MET C . n 
A 1 247 ASN 247 247 247 ASN ASN C . n 
A 1 248 ILE 248 248 248 ILE ILE C . n 
A 1 249 ILE 249 249 249 ILE ILE C . n 
A 1 250 LEU 250 250 250 LEU LEU C . n 
A 1 251 ALA 251 251 251 ALA ALA C . n 
A 1 252 GLY 252 252 252 GLY GLY C . n 
A 1 253 GLY 253 253 253 GLY GLY C . n 
A 1 254 GLN 254 254 254 GLN GLN C . n 
A 1 255 VAL 255 255 255 VAL VAL C . n 
A 1 256 ASP 256 256 256 ASP ASP C . n 
A 1 257 ASN 257 257 257 ASN ASN C . n 
A 1 258 LEU 258 258 258 LEU LEU C . n 
A 1 259 SER 259 259 259 SER SER C . n 
A 1 260 SER 260 260 260 SER SER C . n 
A 1 261 LEU 261 261 261 LEU LEU C . n 
A 1 262 THR 262 262 262 THR THR C . n 
A 1 263 SER 263 263 263 SER SER C . n 
A 1 264 GLU 264 264 264 GLU GLU C . n 
A 1 265 LYS 265 265 265 LYS LYS C . n 
A 1 266 ASN 266 266 266 ASN ASN C . n 
A 1 267 PRO 267 267 267 PRO PRO C . n 
A 1 268 LEU 268 268 268 LEU LEU C . n 
A 1 269 ASP 269 269 269 ASP ASP C . n 
A 1 270 ILE 270 270 270 ILE ILE C . n 
A 1 271 ASP 271 271 271 ASP ASP C . n 
A 1 272 ALA 272 272 272 ALA ALA C . n 
A 1 273 SER 273 273 273 SER SER C . n 
A 1 274 GLY 274 274 274 GLY GLY C . n 
A 1 275 VAL 275 275 275 VAL VAL C . n 
A 1 276 VAL 276 276 276 VAL VAL C . n 
A 1 277 GLY 277 277 277 GLY GLY C . n 
A 1 278 LEU 278 278 278 LEU LEU C . n 
A 1 279 SER 279 279 279 SER SER C . n 
A 1 280 PHE 280 280 280 PHE PHE C . n 
A 1 281 SER 281 281 281 SER SER C . n 
A 1 282 GLY 282 282 282 GLY GLY C . n 
A 1 283 HIS 283 283 283 HIS HIS C . n 
A 1 284 ARG 284 284 284 ARG ARG C . n 
A 1 285 ILE 285 285 285 ILE ILE C . n 
A 1 286 GLN 286 286 286 GLN GLN C . n 
A 1 287 SER 287 287 287 SER SER C . n 
A 1 288 ALA 288 288 288 ALA ALA C . n 
A 1 289 THR 289 289 289 THR THR C . n 
A 1 290 VAL 290 290 290 VAL VAL C . n 
A 1 291 LEU 291 291 291 LEU LEU C . n 
A 1 292 LEU 292 292 292 LEU LEU C . n 
A 1 293 ASN 293 293 293 ASN ASN C . n 
A 1 294 GLU 294 294 294 GLU GLU C . n 
A 1 295 ASP 295 295 295 ASP ASP C . n 
A 1 296 VAL 296 296 296 VAL VAL C . n 
A 1 297 SER 297 297 297 SER SER C . n 
A 1 298 ASP 298 298 298 ASP ASP C . n 
A 1 299 GLU 299 299 299 GLU GLU C . n 
A 1 300 LYS 300 300 300 LYS LYS C . n 
A 1 301 THR 301 301 301 THR THR C . n 
A 1 302 ALA 302 302 302 ALA ALA C . n 
A 1 303 GLU 303 303 303 GLU GLU C . n 
A 1 304 ALA 304 304 304 ALA ALA C . n 
A 1 305 ALA 305 305 305 ALA ALA C . n 
A 1 306 MET 306 306 306 MET MET C . n 
A 1 307 GLN 307 307 307 GLN GLN C . n 
A 1 308 ARG 308 308 308 ARG ARG C . n 
A 1 309 LEU 309 309 309 LEU LEU C . n 
A 1 310 LYS 310 310 310 LYS LYS C . n 
A 1 311 ALA 311 311 311 ALA ALA C . n 
A 1 312 ALA 312 312 312 ALA ALA C . n 
A 1 313 ASN 313 313 313 ASN ASN C . n 
A 1 314 ILE 314 314 314 ILE ILE C . n 
A 1 315 PRO 315 315 315 PRO PRO C . n 
A 1 316 GLU 316 316 316 GLU GLU C . n 
A 1 317 HIS 317 317 317 HIS HIS C . n 
A 1 318 ASN 318 318 318 ASN ASN C . n 
A 1 319 THR 319 319 319 THR THR C . n 
A 1 320 ILE 320 320 320 ILE ILE C . n 
A 1 321 GLY 321 321 321 GLY GLY C . n 
A 1 322 PHE 322 322 322 PHE PHE C . n 
A 1 323 MET 323 323 323 MET MET C . n 
A 1 324 PHE 324 324 324 PHE PHE C . n 
A 1 325 ALA 325 325 325 ALA ALA C . n 
A 1 326 CYS 326 326 326 CYS CYS C . n 
A 1 327 VAL 327 327 327 VAL VAL C . n 
A 1 328 GLY 328 328 328 GLY GLY C . n 
A 1 329 ARG 329 329 329 ARG ARG C . n 
A 1 330 GLY 330 330 330 GLY GLY C . n 
A 1 331 PHE 331 331 331 PHE PHE C . n 
A 1 332 GLN 332 332 332 GLN GLN C . n 
A 1 333 TYR 333 333 333 TYR TYR C . n 
A 1 334 TYR 334 334 334 TYR TYR C . n 
A 1 335 ARG 335 335 335 ARG ARG C . n 
A 1 336 ALA 336 336 336 ALA ALA C . n 
A 1 337 LYS 337 337 337 LYS LYS C . n 
A 1 338 GLY 338 338 338 GLY GLY C . n 
A 1 339 ASN 339 339 339 ASN ASN C . n 
A 1 340 VAL 340 340 340 VAL VAL C . n 
A 1 341 GLU 341 341 341 GLU GLU C . n 
A 1 342 ALA 342 342 342 ALA ALA C . n 
A 1 343 ASP 343 343 343 ASP ASP C . n 
A 1 344 ALA 344 344 344 ALA ALA C . n 
A 1 345 PHE 345 345 345 PHE PHE C . n 
A 1 346 ARG 346 346 346 ARG ARG C . n 
A 1 347 LYS 347 347 347 LYS LYS C . n 
A 1 348 PHE 348 348 348 PHE PHE C . n 
A 1 349 PHE 349 349 349 PHE PHE C . n 
A 1 350 PRO 350 350 350 PRO PRO C . n 
A 1 351 SER 351 351 351 SER SER C . n 
A 1 352 VAL 352 352 352 VAL VAL C . n 
A 1 353 PRO 353 353 353 PRO PRO C . n 
A 1 354 LEU 354 354 354 LEU LEU C . n 
A 1 355 PHE 355 355 355 PHE PHE C . n 
A 1 356 GLY 356 356 356 GLY GLY C . n 
A 1 357 PHE 357 357 357 PHE PHE C . n 
A 1 358 PHE 358 358 358 PHE PHE C . n 
A 1 359 GLY 359 359 359 GLY GLY C . n 
A 1 360 ASN 360 360 360 ASN ASN C . n 
A 1 361 GLY 361 361 361 GLY GLY C . n 
A 1 362 GLU 362 362 362 GLU GLU C . n 
A 1 363 ILE 363 363 363 ILE ILE C . n 
A 1 364 GLY 364 364 364 GLY GLY C . n 
A 1 365 CYS 365 365 365 CYS CYS C . n 
A 1 366 ASP 366 366 366 ASP ASP C . n 
A 1 367 ARG 367 367 367 ARG ARG C . n 
A 1 368 ILE 368 368 368 ILE ILE C . n 
A 1 369 VAL 369 369 369 VAL VAL C . n 
A 1 370 THR 370 370 370 THR THR C . n 
A 1 371 GLY 371 371 371 GLY GLY C . n 
A 1 372 ASN 372 372 372 ASN ASN C . n 
A 1 373 PHE 373 373 373 PHE PHE C . n 
A 1 374 ILE 374 374 374 ILE ILE C . n 
A 1 375 LEU 375 375 375 LEU LEU C . n 
A 1 376 ARG 376 376 376 ARG ARG C . n 
A 1 377 LYS 377 377 377 LYS LYS C . n 
A 1 378 CYS 378 378 378 CYS CYS C . n 
A 1 379 ASN 379 379 379 ASN ASN C . n 
A 1 380 GLU 380 380 380 GLU GLU C . n 
A 1 381 VAL 381 381 381 VAL VAL C . n 
A 1 382 LYS 382 382 382 LYS LYS C . n 
A 1 383 ASP 383 383 383 ASP ASP C . n 
A 1 384 ASP 384 384 384 ASP ASP C . n 
A 1 385 ASP 385 385 385 ASP ASP C . n 
A 1 386 LEU 386 386 386 LEU LEU C . n 
A 1 387 PHE 387 387 387 PHE PHE C . n 
A 1 388 HIS 388 388 388 HIS HIS C . n 
A 1 389 SER 389 389 389 SER SER C . n 
A 1 390 TYR 390 390 390 TYR TYR C . n 
A 1 391 THR 391 391 391 THR THR C . n 
A 1 392 THR 392 392 392 THR THR C . n 
A 1 393 ILE 393 393 393 ILE ILE C . n 
A 1 394 MET 394 394 394 MET MET C . n 
A 1 395 ALA 395 395 395 ALA ALA C . n 
A 1 396 LEU 396 396 396 LEU LEU C . n 
A 1 397 ILE 397 397 397 ILE ILE C . n 
A 1 398 HIS 398 398 398 HIS HIS C . n 
A 1 399 LEU 399 399 399 LEU LEU C . n 
A 1 400 GLY 400 400 400 GLY GLY C . n 
A 1 401 SER 401 401 401 SER SER C . n 
A 1 402 SER 402 402 ?   ?   ?   C . n 
A 1 403 LYS 403 403 ?   ?   ?   C . n 
B 2 1   SER 1   7   7   SER SER D . n 
B 2 2   VAL 2   8   8   VAL VAL D . n 
B 2 3   PHE 3   9   9   PHE PHE D . n 
B 2 4   ALA 4   10  10  ALA ALA D . n 
B 2 5   TYR 5   11  11  TYR TYR D . n 
B 2 6   GLU 6   12  12  GLU GLU D . n 
B 2 7   SER 7   13  13  SER SER D . n 
B 2 8   SER 8   14  14  SER SER D . n 
B 2 9   VAL 9   15  15  VAL VAL D . n 
B 2 10  HIS 10  16  16  HIS HIS D . n 
B 2 11  SER 11  17  17  SER SER D . n 
B 2 12  THR 12  18  18  THR THR D . n 
B 2 13  ASN 13  19  19  ASN ASN D . n 
B 2 14  VAL 14  20  20  VAL VAL D . n 
B 2 15  LEU 15  21  21  LEU LEU D . n 
B 2 16  LEU 16  22  22  LEU LEU D . n 
B 2 17  SER 17  23  23  SER SER D . n 
B 2 18  LEU 18  24  24  LEU LEU D . n 
B 2 19  ASN 19  25  25  ASN ASN D . n 
B 2 20  ASP 20  26  26  ASP ASP D . n 
B 2 21  GLN 21  27  27  GLN GLN D . n 
B 2 22  ARG 22  28  28  ARG ARG D . n 
B 2 23  LYS 23  29  29  LYS LYS D . n 
B 2 24  LYS 24  30  30  LYS LYS D . n 
B 2 25  ASP 25  31  31  ASP ASP D . n 
B 2 26  VAL 26  32  32  VAL VAL D . n 
B 2 27  LEU 27  33  33  LEU LEU D . n 
B 2 28  CYS 28  34  34  CYS CYS D . n 
B 2 29  ASP 29  35  35  ASP ASP D . n 
B 2 30  VAL 30  36  36  VAL VAL D . n 
B 2 31  THR 31  37  37  THR THR D . n 
B 2 32  ILE 32  38  38  ILE ILE D . n 
B 2 33  PHE 33  39  39  PHE PHE D . n 
B 2 34  VAL 34  40  40  VAL VAL D . n 
B 2 35  GLU 35  41  41  GLU GLU D . n 
B 2 36  GLY 36  42  42  GLY GLY D . n 
B 2 37  GLN 37  43  43  GLN GLN D . n 
B 2 38  ARG 38  44  44  ARG ARG D . n 
B 2 39  PHE 39  45  45  PHE PHE D . n 
B 2 40  ARG 40  46  46  ARG ARG D . n 
B 2 41  ALA 41  47  47  ALA ALA D . n 
B 2 42  HIS 42  48  48  HIS HIS D . n 
B 2 43  ARG 43  49  49  ARG ARG D . n 
B 2 44  SER 44  50  50  SER SER D . n 
B 2 45  VAL 45  51  51  VAL VAL D . n 
B 2 46  LEU 46  52  52  LEU LEU D . n 
B 2 47  ALA 47  53  53  ALA ALA D . n 
B 2 48  ALA 48  54  54  ALA ALA D . n 
B 2 49  CYS 49  55  55  CYS CYS D . n 
B 2 50  SER 50  56  56  SER SER D . n 
B 2 51  SER 51  57  57  SER SER D . n 
B 2 52  TYR 52  58  58  TYR TYR D . n 
B 2 53  PHE 53  59  59  PHE PHE D . n 
B 2 54  HIS 54  60  60  HIS HIS D . n 
B 2 55  SER 55  61  61  SER SER D . n 
B 2 56  ARG 56  62  62  ARG ARG D . n 
B 2 57  ILE 57  63  63  ILE ILE D . n 
B 2 58  VAL 58  64  64  VAL VAL D . n 
B 2 59  GLY 59  65  65  GLY GLY D . n 
B 2 60  GLN 60  66  66  GLN GLN D . n 
B 2 61  ALA 61  67  67  ALA ALA D . n 
B 2 62  ASP 62  68  68  ASP ASP D . n 
B 2 63  GLY 63  69  69  GLY GLY D . n 
B 2 64  GLU 64  70  70  GLU GLU D . n 
B 2 65  LEU 65  71  71  LEU LEU D . n 
B 2 66  ASN 66  72  72  ASN ASN D . n 
B 2 67  ILE 67  73  73  ILE ILE D . n 
B 2 68  THR 68  74  74  THR THR D . n 
B 2 69  LEU 69  75  75  LEU LEU D . n 
B 2 70  PRO 70  76  76  PRO PRO D . n 
B 2 71  GLU 71  77  77  GLU GLU D . n 
B 2 72  GLU 72  78  78  GLU GLU D . n 
B 2 73  VAL 73  79  79  VAL VAL D . n 
B 2 74  THR 74  80  80  THR THR D . n 
B 2 75  VAL 75  81  81  VAL VAL D . n 
B 2 76  LYS 76  82  82  LYS LYS D . n 
B 2 77  GLY 77  83  83  GLY GLY D . n 
B 2 78  PHE 78  84  84  PHE PHE D . n 
B 2 79  GLU 79  85  85  GLU GLU D . n 
B 2 80  PRO 80  86  86  PRO PRO D . n 
B 2 81  LEU 81  87  87  LEU LEU D . n 
B 2 82  ILE 82  88  88  ILE ILE D . n 
B 2 83  GLN 83  89  89  GLN GLN D . n 
B 2 84  PHE 84  90  90  PHE PHE D . n 
B 2 85  ALA 85  91  91  ALA ALA D . n 
B 2 86  TYR 86  92  92  TYR TYR D . n 
B 2 87  THR 87  93  93  THR THR D . n 
B 2 88  ALA 88  94  94  ALA ALA D . n 
B 2 89  LYS 89  95  95  LYS LYS D . n 
B 2 90  LEU 90  96  96  LEU LEU D . n 
B 2 91  ILE 91  97  97  ILE ILE D . n 
B 2 92  LEU 92  98  98  LEU LEU D . n 
B 2 93  SER 93  99  99  SER SER D . n 
B 2 94  LYS 94  100 100 LYS LYS D . n 
B 2 95  GLU 95  101 101 GLU GLU D . n 
B 2 96  ASN 96  102 102 ASN ASN D . n 
B 2 97  VAL 97  103 103 VAL VAL D . n 
B 2 98  ASP 98  104 104 ASP ASP D . n 
B 2 99  GLU 99  105 105 GLU GLU D . n 
B 2 100 VAL 100 106 106 VAL VAL D . n 
B 2 101 CYS 101 107 107 CYS CYS D . n 
B 2 102 LYS 102 108 108 LYS LYS D . n 
B 2 103 CYS 103 109 109 CYS CYS D . n 
B 2 104 VAL 104 110 110 VAL VAL D . n 
B 2 105 GLU 105 111 111 GLU GLU D . n 
B 2 106 PHE 106 112 112 PHE PHE D . n 
B 2 107 LEU 107 113 113 LEU LEU D . n 
B 2 108 SER 108 114 114 SER SER D . n 
B 2 109 VAL 109 115 115 VAL VAL D . n 
B 2 110 HIS 110 116 116 HIS HIS D . n 
B 2 111 ASN 111 117 117 ASN ASN D . n 
B 2 112 ILE 112 118 118 ILE ILE D . n 
B 2 113 GLU 113 119 119 GLU GLU D . n 
B 2 114 GLU 114 120 120 GLU GLU D . n 
B 2 115 SER 115 121 121 SER SER D . n 
B 2 116 CYS 116 122 122 CYS CYS D . n 
B 2 117 PHE 117 123 123 PHE PHE D . n 
B 2 118 GLN 118 124 124 GLN GLN D . n 
B 2 119 PHE 119 125 125 PHE PHE D . n 
B 2 120 LEU 120 126 126 LEU LEU D . n 
B 2 121 LYS 121 127 127 LYS LYS D . n 
B 2 122 PHE 122 128 128 PHE PHE D . n 
C 2 1   SER 1   7   7   SER SER E . n 
C 2 2   VAL 2   8   8   VAL VAL E . n 
C 2 3   PHE 3   9   9   PHE PHE E . n 
C 2 4   ALA 4   10  10  ALA ALA E . n 
C 2 5   TYR 5   11  11  TYR TYR E . n 
C 2 6   GLU 6   12  12  GLU GLU E . n 
C 2 7   SER 7   13  13  SER SER E . n 
C 2 8   SER 8   14  14  SER SER E . n 
C 2 9   VAL 9   15  15  VAL VAL E . n 
C 2 10  HIS 10  16  16  HIS HIS E . n 
C 2 11  SER 11  17  17  SER SER E . n 
C 2 12  THR 12  18  18  THR THR E . n 
C 2 13  ASN 13  19  19  ASN ASN E . n 
C 2 14  VAL 14  20  20  VAL VAL E . n 
C 2 15  LEU 15  21  21  LEU LEU E . n 
C 2 16  LEU 16  22  22  LEU LEU E . n 
C 2 17  SER 17  23  23  SER SER E . n 
C 2 18  LEU 18  24  24  LEU LEU E . n 
C 2 19  ASN 19  25  25  ASN ASN E . n 
C 2 20  ASP 20  26  26  ASP ASP E . n 
C 2 21  GLN 21  27  27  GLN GLN E . n 
C 2 22  ARG 22  28  28  ARG ARG E . n 
C 2 23  LYS 23  29  29  LYS LYS E . n 
C 2 24  LYS 24  30  30  LYS LYS E . n 
C 2 25  ASP 25  31  31  ASP ASP E . n 
C 2 26  VAL 26  32  32  VAL VAL E . n 
C 2 27  LEU 27  33  33  LEU LEU E . n 
C 2 28  CYS 28  34  34  CYS CYS E . n 
C 2 29  ASP 29  35  35  ASP ASP E . n 
C 2 30  VAL 30  36  36  VAL VAL E . n 
C 2 31  THR 31  37  37  THR THR E . n 
C 2 32  ILE 32  38  38  ILE ILE E . n 
C 2 33  PHE 33  39  39  PHE PHE E . n 
C 2 34  VAL 34  40  40  VAL VAL E . n 
C 2 35  GLU 35  41  41  GLU GLU E . n 
C 2 36  GLY 36  42  42  GLY GLY E . n 
C 2 37  GLN 37  43  43  GLN GLN E . n 
C 2 38  ARG 38  44  44  ARG ARG E . n 
C 2 39  PHE 39  45  45  PHE PHE E . n 
C 2 40  ARG 40  46  46  ARG ARG E . n 
C 2 41  ALA 41  47  47  ALA ALA E . n 
C 2 42  HIS 42  48  48  HIS HIS E . n 
C 2 43  ARG 43  49  49  ARG ARG E . n 
C 2 44  SER 44  50  50  SER SER E . n 
C 2 45  VAL 45  51  51  VAL VAL E . n 
C 2 46  LEU 46  52  52  LEU LEU E . n 
C 2 47  ALA 47  53  53  ALA ALA E . n 
C 2 48  ALA 48  54  54  ALA ALA E . n 
C 2 49  CYS 49  55  55  CYS CYS E . n 
C 2 50  SER 50  56  56  SER SER E . n 
C 2 51  SER 51  57  57  SER SER E . n 
C 2 52  TYR 52  58  58  TYR TYR E . n 
C 2 53  PHE 53  59  59  PHE PHE E . n 
C 2 54  HIS 54  60  60  HIS HIS E . n 
C 2 55  SER 55  61  61  SER SER E . n 
C 2 56  ARG 56  62  62  ARG ARG E . n 
C 2 57  ILE 57  63  63  ILE ILE E . n 
C 2 58  VAL 58  64  64  VAL VAL E . n 
C 2 59  GLY 59  65  65  GLY GLY E . n 
C 2 60  GLN 60  66  66  GLN GLN E . n 
C 2 61  ALA 61  67  67  ALA ALA E . n 
C 2 62  ASP 62  68  68  ASP ASP E . n 
C 2 63  GLY 63  69  69  GLY GLY E . n 
C 2 64  GLU 64  70  70  GLU GLU E . n 
C 2 65  LEU 65  71  71  LEU LEU E . n 
C 2 66  ASN 66  72  72  ASN ASN E . n 
C 2 67  ILE 67  73  73  ILE ILE E . n 
C 2 68  THR 68  74  74  THR THR E . n 
C 2 69  LEU 69  75  75  LEU LEU E . n 
C 2 70  PRO 70  76  76  PRO PRO E . n 
C 2 71  GLU 71  77  77  GLU GLU E . n 
C 2 72  GLU 72  78  78  GLU GLU E . n 
C 2 73  VAL 73  79  79  VAL VAL E . n 
C 2 74  THR 74  80  80  THR THR E . n 
C 2 75  VAL 75  81  81  VAL VAL E . n 
C 2 76  LYS 76  82  82  LYS LYS E . n 
C 2 77  GLY 77  83  83  GLY GLY E . n 
C 2 78  PHE 78  84  84  PHE PHE E . n 
C 2 79  GLU 79  85  85  GLU GLU E . n 
C 2 80  PRO 80  86  86  PRO PRO E . n 
C 2 81  LEU 81  87  87  LEU LEU E . n 
C 2 82  ILE 82  88  88  ILE ILE E . n 
C 2 83  GLN 83  89  89  GLN GLN E . n 
C 2 84  PHE 84  90  90  PHE PHE E . n 
C 2 85  ALA 85  91  91  ALA ALA E . n 
C 2 86  TYR 86  92  92  TYR TYR E . n 
C 2 87  THR 87  93  93  THR THR E . n 
C 2 88  ALA 88  94  94  ALA ALA E . n 
C 2 89  LYS 89  95  95  LYS LYS E . n 
C 2 90  LEU 90  96  96  LEU LEU E . n 
C 2 91  ILE 91  97  97  ILE ILE E . n 
C 2 92  LEU 92  98  98  LEU LEU E . n 
C 2 93  SER 93  99  99  SER SER E . n 
C 2 94  LYS 94  100 100 LYS LYS E . n 
C 2 95  GLU 95  101 101 GLU GLU E . n 
C 2 96  ASN 96  102 102 ASN ASN E . n 
C 2 97  VAL 97  103 103 VAL VAL E . n 
C 2 98  ASP 98  104 104 ASP ASP E . n 
C 2 99  GLU 99  105 105 GLU GLU E . n 
C 2 100 VAL 100 106 106 VAL VAL E . n 
C 2 101 CYS 101 107 107 CYS CYS E . n 
C 2 102 LYS 102 108 108 LYS LYS E . n 
C 2 103 CYS 103 109 109 CYS CYS E . n 
C 2 104 VAL 104 110 110 VAL VAL E . n 
C 2 105 GLU 105 111 111 GLU GLU E . n 
C 2 106 PHE 106 112 112 PHE PHE E . n 
C 2 107 LEU 107 113 113 LEU LEU E . n 
C 2 108 SER 108 114 114 SER SER E . n 
C 2 109 VAL 109 115 115 VAL VAL E . n 
C 2 110 HIS 110 116 116 HIS HIS E . n 
C 2 111 ASN 111 117 117 ASN ASN E . n 
C 2 112 ILE 112 118 118 ILE ILE E . n 
C 2 113 GLU 113 119 119 GLU GLU E . n 
C 2 114 GLU 114 120 120 GLU GLU E . n 
C 2 115 SER 115 121 121 SER SER E . n 
C 2 116 CYS 116 122 122 CYS CYS E . n 
C 2 117 PHE 117 123 123 PHE PHE E . n 
C 2 118 GLN 118 124 124 GLN GLN E . n 
C 2 119 PHE 119 125 125 PHE PHE E . n 
C 2 120 LEU 120 126 126 LEU LEU E . n 
C 2 121 LYS 121 127 127 LYS LYS E . n 
C 2 122 PHE 122 128 ?   ?   ?   E . n 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8UA3 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8UA3 
_struct.title                        'Cryo-EM Structure of FBOX22-BACH1BTB' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8UA3 
_struct_keywords.text            'F-box protein, FBXO22, BACH1, LIGASE' 
_struct_keywords.pdbx_keywords   LIGASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP FBX22_HUMAN Q8NEZ5 ? 1 
;MEPVGCCGECRGSSVDPRSTFVLSNLAEVVERVLTFLPAKALLRVACVCRLWRECVRRVLRTHRSVTWISAGLAEAGHLE
GHCLVRVVAEELENVRILPHTVLYMADSETFISLEECRGHKRARKRTSMETALALEKLFPKQCQVLGIVTPGIVVTPMGS
GSNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDPKNLTLERHQLTEVGLLDNPELRVVLVFGYNCCKVGASNYLQQVV
STFSDMNIILAGGQVDNLSSLTSEKNPLDIDASGVVGLSFSGHRIQSATVLLNEDVSDEKTAEAAMQRLKAANIPEHNTI
GFMFACVGRGFQYYRAKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRKCNEVKDDDLFHSYTTIMALIHLG
SSK
;
1 
2 UNP BACH1_HUMAN O14867 ? 2 
;SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKF
;
7 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8UA3 C 1 ? 403 ? Q8NEZ5 1 ? 403 ? 1 403 
2 2 8UA3 D 1 ? 122 ? O14867 7 ? 128 ? 7 128 
3 2 8UA3 E 1 ? 122 ? O14867 7 ? 128 ? 7 128 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 72  ? ALA A 76  ? GLY C 72  ALA C 76  5 ? 5  
HELX_P HELX_P2  AA2 HIS A 82  ? LEU A 92  ? HIS C 82  LEU C 92  1 ? 11 
HELX_P HELX_P3  AA3 GLU A 93  ? VAL A 95  ? GLU C 93  VAL C 95  5 ? 3  
HELX_P HELX_P4  AA4 SER A 128 ? PHE A 139 ? SER C 128 PHE C 139 1 ? 12 
HELX_P HELX_P5  AA5 HIS A 204 ? VAL A 209 ? HIS C 204 VAL C 209 1 ? 6  
HELX_P HELX_P6  AA6 GLY A 231 ? SER A 244 ? GLY C 231 SER C 244 1 ? 14 
HELX_P HELX_P7  AA7 ASP A 298 ? ALA A 311 ? ASP C 298 ALA C 311 1 ? 14 
HELX_P HELX_P8  AA8 ASN A 339 ? PHE A 349 ? ASN C 339 PHE C 349 1 ? 11 
HELX_P HELX_P9  AA9 VAL B 9   ? LYS B 24  ? VAL D 15  LYS D 30  1 ? 16 
HELX_P HELX_P10 AB1 HIS B 42  ? SER B 50  ? HIS D 48  SER D 56  1 ? 9  
HELX_P HELX_P11 AB2 THR B 74  ? ALA B 88  ? THR D 80  ALA D 94  1 ? 15 
HELX_P HELX_P12 AB3 GLU B 95  ? PHE B 106 ? GLU D 101 PHE D 112 1 ? 12 
HELX_P HELX_P13 AB4 VAL C 9   ? LYS C 23  ? VAL E 15  LYS E 29  1 ? 15 
HELX_P HELX_P14 AB5 VAL C 45  ? SER C 50  ? VAL E 51  SER E 56  1 ? 6  
HELX_P HELX_P15 AB6 SER C 51  ? VAL C 58  ? SER E 57  VAL E 64  1 ? 8  
HELX_P HELX_P16 AB7 PHE C 78  ? ALA C 88  ? PHE E 84  ALA E 94  1 ? 11 
HELX_P HELX_P17 AB8 ASN C 96  ? SER C 108 ? ASN E 102 SER E 114 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
AA7 ? 3 ? 
AA8 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? parallel      
AA8 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 67  ? ALA A 71  ? THR C 67  ALA C 71  
AA1 2 GLY A 174 ? PHE A 179 ? GLY C 174 PHE C 179 
AA1 3 THR A 101 ? ALA A 106 ? THR C 101 ALA C 106 
AA1 4 GLN A 144 ? VAL A 149 ? GLN C 144 VAL C 149 
AA1 5 ASN A 257 ? LEU A 261 ? ASN C 257 LEU C 261 
AA2 1 GLN A 166 ? ILE A 168 ? GLN C 166 ILE C 168 
AA2 2 ILE A 153 ? VAL A 155 ? ILE C 153 VAL C 155 
AA2 3 LEU A 354 ? GLY A 359 ? LEU C 354 GLY C 359 
AA2 4 ILE A 320 ? CYS A 326 ? ILE C 320 CYS C 326 
AA2 5 THR A 392 ? ILE A 397 ? THR C 392 ILE C 397 
AA2 6 LEU A 291 ? LEU A 292 ? LEU C 291 LEU C 292 
AA3 1 PHE A 190 ? ILE A 193 ? PHE C 190 ILE C 193 
AA3 2 GLY A 274 ? GLY A 277 ? GLY C 274 GLY C 277 
AA3 3 PHE A 223 ? TYR A 225 ? PHE C 223 TYR C 225 
AA3 4 GLN A 254 ? VAL A 255 ? GLN C 254 VAL C 255 
AA4 1 LEU A 217 ? VAL A 220 ? LEU C 217 VAL C 220 
AA4 2 SER A 279 ? SER A 281 ? SER C 279 SER C 281 
AA5 1 GLU A 362 ? ILE A 363 ? GLU C 362 ILE C 363 
AA5 2 PHE A 387 ? HIS A 388 ? PHE C 387 HIS C 388 
AA6 1 PHE A 373 ? ILE A 374 ? PHE C 373 ILE C 374 
AA6 2 GLU C 6   ? SER C 7   ? GLU E 12  SER E 13  
AA7 1 PHE B 39  ? ALA B 41  ? PHE D 45  ALA D 47  
AA7 2 VAL B 30  ? VAL B 34  ? VAL D 36  VAL D 40  
AA7 3 ASN B 66  ? LEU B 69  ? ASN D 72  LEU D 75  
AA8 1 VAL C 30  ? VAL C 34  ? VAL E 36  VAL E 40  
AA8 2 GLN C 37  ? ALA C 41  ? GLN E 43  ALA E 47  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 69  ? N ILE C 69  O ALA A 176 ? O ALA C 176 
AA1 2 3 O PHE A 179 ? O PHE C 179 N THR A 101 ? N THR C 101 
AA1 3 4 N VAL A 102 ? N VAL C 102 O GLN A 144 ? O GLN C 144 
AA1 4 5 N GLY A 147 ? N GLY C 147 O SER A 259 ? O SER C 259 
AA2 1 2 O GLN A 166 ? O GLN C 166 N VAL A 155 ? N VAL C 155 
AA2 2 3 N VAL A 154 ? N VAL C 154 O GLY A 356 ? O GLY C 356 
AA2 3 4 O GLY A 359 ? O GLY C 359 N ALA A 325 ? N ALA C 325 
AA2 4 5 N PHE A 324 ? N PHE C 324 O ILE A 393 ? O ILE C 393 
AA2 5 6 O THR A 392 ? O THR C 392 N LEU A 292 ? N LEU C 292 
AA3 1 2 N PHE A 192 ? N PHE C 192 O VAL A 275 ? O VAL C 275 
AA3 2 3 O VAL A 276 ? O VAL C 276 N PHE A 223 ? N PHE C 223 
AA3 3 4 N GLY A 224 ? N GLY C 224 O VAL A 255 ? O VAL C 255 
AA4 1 2 N VAL A 219 ? N VAL C 219 O PHE A 280 ? O PHE C 280 
AA5 1 2 N GLU A 362 ? N GLU C 362 O HIS A 388 ? O HIS C 388 
AA6 1 2 N ILE A 374 ? N ILE C 374 O GLU C 6   ? O GLU E 12  
AA7 1 2 O PHE B 39  ? O PHE D 45  N ILE B 32  ? N ILE D 38  
AA7 2 3 N PHE B 33  ? N PHE D 39  O LEU B 69  ? O LEU D 75  
AA8 1 2 N ILE C 32  ? N ILE E 38  O PHE C 39  ? O PHE E 45  
# 
_pdbx_entry_details.entry_id                   8UA3 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CG 
_pdbx_validate_rmsd_bond.auth_asym_id_1            D 
_pdbx_validate_rmsd_bond.auth_comp_id_1            PRO 
_pdbx_validate_rmsd_bond.auth_seq_id_1             86 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_2            D 
_pdbx_validate_rmsd_bond.auth_comp_id_2            PRO 
_pdbx_validate_rmsd_bond.auth_seq_id_2             86 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.157 
_pdbx_validate_rmsd_bond.bond_target_value         1.502 
_pdbx_validate_rmsd_bond.bond_deviation            -0.345 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.033 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CA D PRO 86 ? ? N  D PRO 86 ? ? CD D PRO 86 ? ? 94.95 111.70 -16.75 1.40 N 
2 1 CA D PRO 86 ? ? CB D PRO 86 ? ? CG D PRO 86 ? ? 92.33 104.80 -12.47 1.90 N 
3 1 N  D PRO 86 ? ? CD D PRO 86 ? ? CG D PRO 86 ? ? 85.24 103.20 -17.96 1.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER C 108 ? ? -94.54  36.16   
2  1 GLU C 115 ? ? -140.17 -15.16  
3  1 ASN C 198 ? ? -163.00 -169.22 
4  1 THR C 200 ? ? -99.57  -68.92  
5  1 LEU C 201 ? ? -164.63 109.64  
6  1 GLU C 202 ? ? -69.63  -74.55  
7  1 ARG C 203 ? ? -150.35 -27.42  
8  1 ASP C 213 ? ? 58.58   19.82   
9  1 ASN C 247 ? ? -94.51  57.17   
10 1 LYS C 265 ? ? -141.03 12.05   
11 1 ASN C 293 ? ? -78.84  -167.59 
12 1 ASN C 379 ? ? 36.33   51.48   
13 1 VAL C 381 ? ? -83.25  -78.19  
14 1 LYS C 382 ? ? -135.21 -68.15  
15 1 ASP C 383 ? ? -151.30 30.40   
16 1 ALA D 10  ? ? 65.47   121.52  
17 1 GLU D 41  ? ? 49.29   -122.73 
18 1 GLN D 124 ? ? -82.26  49.58   
19 1 ASP E 31  ? ? 36.40   -74.54  
20 1 GLU E 41  ? ? 59.17   19.41   
21 1 GLU E 77  ? ? -141.86 -24.48  
22 1 ALA E 94  ? ? 70.75   37.27   
23 1 GLU E 120 ? ? -69.65  8.43    
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8UA3 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8UA3 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.8 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               171378 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 FBXO22-BACH1BTB 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1,2 
# 
_em_imaging.entry_id                        8UA3 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             3500 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8UA3 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8UA3 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 C MET 1   ? A MET 1   
2  1 Y 1 C GLU 2   ? A GLU 2   
3  1 Y 1 C PRO 3   ? A PRO 3   
4  1 Y 1 C VAL 4   ? A VAL 4   
5  1 Y 1 C GLY 5   ? A GLY 5   
6  1 Y 1 C CYS 6   ? A CYS 6   
7  1 Y 1 C CYS 7   ? A CYS 7   
8  1 Y 1 C GLY 8   ? A GLY 8   
9  1 Y 1 C GLU 9   ? A GLU 9   
10 1 Y 1 C CYS 10  ? A CYS 10  
11 1 Y 1 C ARG 11  ? A ARG 11  
12 1 Y 1 C GLY 12  ? A GLY 12  
13 1 Y 1 C SER 13  ? A SER 13  
14 1 Y 1 C SER 14  ? A SER 14  
15 1 Y 1 C VAL 15  ? A VAL 15  
16 1 Y 1 C ASP 16  ? A ASP 16  
17 1 Y 1 C PRO 17  ? A PRO 17  
18 1 Y 1 C ARG 18  ? A ARG 18  
19 1 Y 1 C SER 19  ? A SER 19  
20 1 Y 1 C THR 20  ? A THR 20  
21 1 Y 1 C PHE 21  ? A PHE 21  
22 1 Y 1 C VAL 22  ? A VAL 22  
23 1 Y 1 C LEU 23  ? A LEU 23  
24 1 Y 1 C SER 24  ? A SER 24  
25 1 Y 1 C ASN 25  ? A ASN 25  
26 1 Y 1 C LEU 26  ? A LEU 26  
27 1 Y 1 C ALA 27  ? A ALA 27  
28 1 Y 1 C GLU 28  ? A GLU 28  
29 1 Y 1 C VAL 29  ? A VAL 29  
30 1 Y 1 C VAL 30  ? A VAL 30  
31 1 Y 1 C GLU 31  ? A GLU 31  
32 1 Y 1 C ARG 32  ? A ARG 32  
33 1 Y 1 C VAL 33  ? A VAL 33  
34 1 Y 1 C LEU 34  ? A LEU 34  
35 1 Y 1 C THR 35  ? A THR 35  
36 1 Y 1 C PHE 36  ? A PHE 36  
37 1 Y 1 C LEU 37  ? A LEU 37  
38 1 Y 1 C PRO 38  ? A PRO 38  
39 1 Y 1 C ALA 39  ? A ALA 39  
40 1 Y 1 C LYS 40  ? A LYS 40  
41 1 Y 1 C ALA 41  ? A ALA 41  
42 1 Y 1 C LEU 42  ? A LEU 42  
43 1 Y 1 C LEU 43  ? A LEU 43  
44 1 Y 1 C ARG 44  ? A ARG 44  
45 1 Y 1 C VAL 45  ? A VAL 45  
46 1 Y 1 C ALA 46  ? A ALA 46  
47 1 Y 1 C CYS 47  ? A CYS 47  
48 1 Y 1 C VAL 48  ? A VAL 48  
49 1 Y 1 C CYS 49  ? A CYS 49  
50 1 Y 1 C ARG 50  ? A ARG 50  
51 1 Y 1 C LEU 51  ? A LEU 51  
52 1 Y 1 C TRP 52  ? A TRP 52  
53 1 Y 1 C ARG 53  ? A ARG 53  
54 1 Y 1 C GLU 54  ? A GLU 54  
55 1 Y 1 C CYS 55  ? A CYS 55  
56 1 Y 1 C VAL 56  ? A VAL 56  
57 1 Y 1 C ARG 57  ? A ARG 57  
58 1 Y 1 C ARG 58  ? A ARG 58  
59 1 Y 1 C VAL 59  ? A VAL 59  
60 1 Y 1 C LEU 60  ? A LEU 60  
61 1 Y 1 C ARG 61  ? A ARG 61  
62 1 Y 1 C THR 62  ? A THR 62  
63 1 Y 1 C HIS 63  ? A HIS 63  
64 1 Y 1 C ARG 64  ? A ARG 64  
65 1 Y 1 C CYS 117 ? A CYS 117 
66 1 Y 1 C ARG 118 ? A ARG 118 
67 1 Y 1 C GLY 119 ? A GLY 119 
68 1 Y 1 C HIS 120 ? A HIS 120 
69 1 Y 1 C LYS 121 ? A LYS 121 
70 1 Y 1 C ARG 122 ? A ARG 122 
71 1 Y 1 C ALA 123 ? A ALA 123 
72 1 Y 1 C ARG 124 ? A ARG 124 
73 1 Y 1 C LYS 125 ? A LYS 125 
74 1 Y 1 C ARG 126 ? A ARG 126 
75 1 Y 1 C SER 402 ? A SER 402 
76 1 Y 1 C LYS 403 ? A LYS 403 
77 1 Y 1 E PHE 128 ? C PHE 122 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-09-20 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8UA3 
_em_admin.last_update        2025-01-08 
_em_admin.map_release_date   2024-11-06 
_em_admin.title              'Cryo-EM Structure of FBOX22-BACH1BTB' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7111 
_em_entity_assembly_recombinant.organism             'Trichoplusia ni' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         59 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ?         ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 SerialEM  ? 
MASKING                    ? 3  ? ? ? ?         ? 
'CTF CORRECTION'           ? 4  1 ? ? CTFFIND   ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ?         ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?         ? 
'MODEL FITTING'            ? 7  ? ? ? ?         ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ?         ? 
OTHER                      ? 9  ? ? ? ?         ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? cryoSPARC ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? cryoSPARC ? 
CLASSIFICATION             ? 12 1 ? ? cryoSPARC ? 
RECONSTRUCTION             ? 13 1 ? ? ?         ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Howard Hughes Medical Institute (HHMI)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8UA3 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . SER A 1 65  ? 169.489 157.834 194.490 1.00 66.12  ? 65  SER C N   1 
ATOM 2    C CA  . SER A 1 65  ? 170.303 156.980 193.637 1.00 66.12  ? 65  SER C CA  1 
ATOM 3    C C   . SER A 1 65  ? 170.064 155.523 193.997 1.00 66.12  ? 65  SER C C   1 
ATOM 4    O O   . SER A 1 65  ? 170.060 155.165 195.178 1.00 66.12  ? 65  SER C O   1 
ATOM 5    C CB  . SER A 1 65  ? 171.791 157.321 193.776 1.00 66.12  ? 65  SER C CB  1 
ATOM 6    O OG  . SER A 1 65  ? 172.365 156.642 194.879 1.00 66.12  ? 65  SER C OG  1 
ATOM 7    N N   . VAL A 1 66  ? 169.866 154.691 192.980 1.00 52.35  ? 66  VAL C N   1 
ATOM 8    C CA  . VAL A 1 66  ? 169.711 153.256 193.184 1.00 52.35  ? 66  VAL C CA  1 
ATOM 9    C C   . VAL A 1 66  ? 171.086 152.616 193.330 1.00 52.35  ? 66  VAL C C   1 
ATOM 10   O O   . VAL A 1 66  ? 172.048 152.987 192.648 1.00 52.35  ? 66  VAL C O   1 
ATOM 11   C CB  . VAL A 1 66  ? 168.906 152.630 192.027 1.00 52.35  ? 66  VAL C CB  1 
ATOM 12   C CG1 . VAL A 1 66  ? 169.616 152.843 190.701 1.00 52.35  ? 66  VAL C CG1 1 
ATOM 13   C CG2 . VAL A 1 66  ? 168.672 151.151 192.277 1.00 52.35  ? 66  VAL C CG2 1 
ATOM 14   N N   . THR A 1 67  ? 171.187 151.654 194.244 1.00 54.50  ? 67  THR C N   1 
ATOM 15   C CA  . THR A 1 67  ? 172.434 150.953 194.509 1.00 54.50  ? 67  THR C CA  1 
ATOM 16   C C   . THR A 1 67  ? 172.203 149.455 194.387 1.00 54.50  ? 67  THR C C   1 
ATOM 17   O O   . THR A 1 67  ? 171.184 148.930 194.844 1.00 54.50  ? 67  THR C O   1 
ATOM 18   C CB  . THR A 1 67  ? 172.982 151.292 195.901 1.00 54.50  ? 67  THR C CB  1 
ATOM 19   O OG1 . THR A 1 67  ? 173.160 152.709 196.009 1.00 54.50  ? 67  THR C OG1 1 
ATOM 20   C CG2 . THR A 1 67  ? 174.315 150.603 196.140 1.00 54.50  ? 67  THR C CG2 1 
ATOM 21   N N   . TRP A 1 68  ? 173.159 148.769 193.764 1.00 59.03  ? 68  TRP C N   1 
ATOM 22   C CA  . TRP A 1 68  ? 173.028 147.351 193.470 1.00 59.03  ? 68  TRP C CA  1 
ATOM 23   C C   . TRP A 1 68  ? 174.183 146.566 194.073 1.00 59.03  ? 68  TRP C C   1 
ATOM 24   O O   . TRP A 1 68  ? 175.318 147.044 194.135 1.00 59.03  ? 68  TRP C O   1 
ATOM 25   C CB  . TRP A 1 68  ? 172.963 147.104 191.960 1.00 59.03  ? 68  TRP C CB  1 
ATOM 26   C CG  . TRP A 1 68  ? 174.217 147.453 191.223 1.00 59.03  ? 68  TRP C CG  1 
ATOM 27   C CD1 . TRP A 1 68  ? 175.258 146.621 190.941 1.00 59.03  ? 68  TRP C CD1 1 
ATOM 28   C CD2 . TRP A 1 68  ? 174.552 148.722 190.648 1.00 59.03  ? 68  TRP C CD2 1 
ATOM 29   N NE1 . TRP A 1 68  ? 176.226 147.294 190.237 1.00 59.03  ? 68  TRP C NE1 1 
ATOM 30   C CE2 . TRP A 1 68  ? 175.816 148.586 190.044 1.00 59.03  ? 68  TRP C CE2 1 
ATOM 31   C CE3 . TRP A 1 68  ? 173.908 149.961 190.592 1.00 59.03  ? 68  TRP C CE3 1 
ATOM 32   C CZ2 . TRP A 1 68  ? 176.449 149.641 189.392 1.00 59.03  ? 68  TRP C CZ2 1 
ATOM 33   C CZ3 . TRP A 1 68  ? 174.538 151.007 189.943 1.00 59.03  ? 68  TRP C CZ3 1 
ATOM 34   C CH2 . TRP A 1 68  ? 175.795 150.840 189.353 1.00 59.03  ? 68  TRP C CH2 1 
ATOM 35   N N   . ILE A 1 69  ? 173.873 145.351 194.518 1.00 62.04  ? 69  ILE C N   1 
ATOM 36   C CA  . ILE A 1 69  ? 174.848 144.423 195.075 1.00 62.04  ? 69  ILE C CA  1 
ATOM 37   C C   . ILE A 1 69  ? 174.716 143.098 194.338 1.00 62.04  ? 69  ILE C C   1 
ATOM 38   O O   . ILE A 1 69  ? 173.603 142.594 194.151 1.00 62.04  ? 69  ILE C O   1 
ATOM 39   C CB  . ILE A 1 69  ? 174.644 144.220 196.590 1.00 62.04  ? 69  ILE C CB  1 
ATOM 40   C CG1 . ILE A 1 69  ? 174.728 145.554 197.327 1.00 62.04  ? 69  ILE C CG1 1 
ATOM 41   C CG2 . ILE A 1 69  ? 175.662 143.238 197.140 1.00 62.04  ? 69  ILE C CG2 1 
ATOM 42   C CD1 . ILE A 1 69  ? 174.268 145.478 198.764 1.00 62.04  ? 69  ILE C CD1 1 
ATOM 43   N N   . SER A 1 70  ? 175.847 142.531 193.922 1.00 68.96  ? 70  SER C N   1 
ATOM 44   C CA  . SER A 1 70  ? 175.850 141.299 193.149 1.00 68.96  ? 70  SER C CA  1 
ATOM 45   C C   . SER A 1 70  ? 176.889 140.329 193.692 1.00 68.96  ? 70  SER C C   1 
ATOM 46   O O   . SER A 1 70  ? 177.780 140.700 194.459 1.00 68.96  ? 70  SER C O   1 
ATOM 47   C CB  . SER A 1 70  ? 176.124 141.567 191.668 1.00 68.96  ? 70  SER C CB  1 
ATOM 48   O OG  . SER A 1 70  ? 177.436 142.054 191.468 1.00 68.96  ? 70  SER C OG  1 
ATOM 49   N N   . ALA A 1 71  ? 176.759 139.071 193.275 1.00 82.59  ? 71  ALA C N   1 
ATOM 50   C CA  . ALA A 1 71  ? 177.670 137.998 193.661 1.00 82.59  ? 71  ALA C CA  1 
ATOM 51   C C   . ALA A 1 71  ? 178.176 137.318 192.395 1.00 82.59  ? 71  ALA C C   1 
ATOM 52   O O   . ALA A 1 71  ? 177.426 136.596 191.730 1.00 82.59  ? 71  ALA C O   1 
ATOM 53   C CB  . ALA A 1 71  ? 176.979 136.997 194.586 1.00 82.59  ? 71  ALA C CB  1 
ATOM 54   N N   . GLY A 1 72  ? 179.450 137.550 192.064 1.00 105.82 ? 72  GLY C N   1 
ATOM 55   C CA  . GLY A 1 72  ? 180.024 137.004 190.855 1.00 105.82 ? 72  GLY C CA  1 
ATOM 56   C C   . GLY A 1 72  ? 180.498 135.568 191.005 1.00 105.82 ? 72  GLY C C   1 
ATOM 57   O O   . GLY A 1 72  ? 180.367 134.949 192.059 1.00 105.82 ? 72  GLY C O   1 
ATOM 58   N N   . LEU A 1 73  ? 181.057 135.040 189.914 1.00 104.67 ? 73  LEU C N   1 
ATOM 59   C CA  . LEU A 1 73  ? 181.558 133.671 189.898 1.00 104.67 ? 73  LEU C CA  1 
ATOM 60   C C   . LEU A 1 73  ? 182.932 133.531 190.537 1.00 104.67 ? 73  LEU C C   1 
ATOM 61   O O   . LEU A 1 73  ? 183.360 132.402 190.798 1.00 104.67 ? 73  LEU C O   1 
ATOM 62   C CB  . LEU A 1 73  ? 181.611 133.150 188.461 1.00 104.67 ? 73  LEU C CB  1 
ATOM 63   C CG  . LEU A 1 73  ? 180.308 132.602 187.877 1.00 104.67 ? 73  LEU C CG  1 
ATOM 64   C CD1 . LEU A 1 73  ? 180.440 132.397 186.376 1.00 104.67 ? 73  LEU C CD1 1 
ATOM 65   C CD2 . LEU A 1 73  ? 179.917 131.305 188.566 1.00 104.67 ? 73  LEU C CD2 1 
ATOM 66   N N   . ALA A 1 74  ? 183.629 134.636 190.796 1.00 118.95 ? 74  ALA C N   1 
ATOM 67   C CA  . ALA A 1 74  ? 184.973 134.602 191.357 1.00 118.95 ? 74  ALA C CA  1 
ATOM 68   C C   . ALA A 1 74  ? 184.985 134.428 192.871 1.00 118.95 ? 74  ALA C C   1 
ATOM 69   O O   . ALA A 1 74  ? 186.018 134.687 193.502 1.00 118.95 ? 74  ALA C O   1 
ATOM 70   C CB  . ALA A 1 74  ? 185.736 135.872 190.972 1.00 118.95 ? 74  ALA C CB  1 
ATOM 71   N N   . GLU A 1 75  ? 183.876 134.003 193.468 1.00 129.06 ? 75  GLU C N   1 
ATOM 72   C CA  . GLU A 1 75  ? 183.770 133.814 194.911 1.00 129.06 ? 75  GLU C CA  1 
ATOM 73   C C   . GLU A 1 75  ? 183.107 132.480 195.225 1.00 129.06 ? 75  GLU C C   1 
ATOM 74   O O   . GLU A 1 75  ? 182.204 132.382 196.059 1.00 129.06 ? 75  GLU C O   1 
ATOM 75   C CB  . GLU A 1 75  ? 183.005 134.966 195.554 1.00 129.06 ? 75  GLU C CB  1 
ATOM 76   C CG  . GLU A 1 75  ? 183.829 136.228 195.735 1.00 129.06 ? 75  GLU C CG  1 
ATOM 77   C CD  . GLU A 1 75  ? 183.037 137.351 196.370 1.00 129.06 ? 75  GLU C CD  1 
ATOM 78   O OE1 . GLU A 1 75  ? 181.825 137.163 196.603 1.00 129.06 ? 75  GLU C OE1 1 
ATOM 79   O OE2 . GLU A 1 75  ? 183.625 138.420 196.636 1.00 129.06 ? 75  GLU C OE2 1 
ATOM 80   N N   . ALA A 1 76  ? 183.557 131.424 194.551 1.00 126.34 ? 76  ALA C N   1 
ATOM 81   C CA  . ALA A 1 76  ? 183.028 130.078 194.776 1.00 126.34 ? 76  ALA C CA  1 
ATOM 82   C C   . ALA A 1 76  ? 183.767 129.402 195.933 1.00 126.34 ? 76  ALA C C   1 
ATOM 83   O O   . ALA A 1 76  ? 184.423 128.371 195.782 1.00 126.34 ? 76  ALA C O   1 
ATOM 84   C CB  . ALA A 1 76  ? 183.119 129.254 193.498 1.00 126.34 ? 76  ALA C CB  1 
ATOM 85   N N   . GLY A 1 77  ? 183.650 130.017 197.107 1.00 128.13 ? 77  GLY C N   1 
ATOM 86   C CA  . GLY A 1 77  ? 184.286 129.506 198.305 1.00 128.13 ? 77  GLY C CA  1 
ATOM 87   C C   . GLY A 1 77  ? 183.815 128.118 198.686 1.00 128.13 ? 77  GLY C C   1 
ATOM 88   O O   . GLY A 1 77  ? 182.609 127.854 198.725 1.00 128.13 ? 77  GLY C O   1 
ATOM 89   N N   . HIS A 1 78  ? 184.758 127.220 198.969 1.00 137.79 ? 78  HIS C N   1 
ATOM 90   C CA  . HIS A 1 78  ? 184.435 125.841 199.331 1.00 137.79 ? 78  HIS C CA  1 
ATOM 91   C C   . HIS A 1 78  ? 184.138 125.736 200.829 1.00 137.79 ? 78  HIS C C   1 
ATOM 92   O O   . HIS A 1 78  ? 184.797 125.023 201.586 1.00 137.79 ? 78  HIS C O   1 
ATOM 93   C CB  . HIS A 1 78  ? 185.569 124.911 198.920 1.00 137.79 ? 78  HIS C CB  1 
ATOM 94   C CG  . HIS A 1 78  ? 185.738 124.785 197.439 1.00 137.79 ? 78  HIS C CG  1 
ATOM 95   N ND1 . HIS A 1 78  ? 186.492 125.669 196.698 1.00 137.79 ? 78  HIS C ND1 1 
ATOM 96   C CD2 . HIS A 1 78  ? 185.249 123.879 196.559 1.00 137.79 ? 78  HIS C CD2 1 
ATOM 97   C CE1 . HIS A 1 78  ? 186.461 125.313 195.426 1.00 137.79 ? 78  HIS C CE1 1 
ATOM 98   N NE2 . HIS A 1 78  ? 185.713 124.230 195.315 1.00 137.79 ? 78  HIS C NE2 1 
ATOM 99   N N   . LEU A 1 79  ? 183.114 126.475 201.248 1.00 128.86 ? 79  LEU C N   1 
ATOM 100  C CA  . LEU A 1 79  ? 182.660 126.480 202.629 1.00 128.86 ? 79  LEU C CA  1 
ATOM 101  C C   . LEU A 1 79  ? 181.140 126.497 202.660 1.00 128.86 ? 79  LEU C C   1 
ATOM 102  O O   . LEU A 1 79  ? 180.488 126.919 201.700 1.00 128.86 ? 79  LEU C O   1 
ATOM 103  C CB  . LEU A 1 79  ? 183.227 127.681 203.405 1.00 128.86 ? 79  LEU C CB  1 
ATOM 104  C CG  . LEU A 1 79  ? 182.791 129.087 202.985 1.00 128.86 ? 79  LEU C CG  1 
ATOM 105  C CD1 . LEU A 1 79  ? 181.672 129.610 203.877 1.00 128.86 ? 79  LEU C CD1 1 
ATOM 106  C CD2 . LEU A 1 79  ? 183.980 130.034 203.003 1.00 128.86 ? 79  LEU C CD2 1 
ATOM 107  N N   . GLU A 1 80  ? 180.582 126.030 203.774 1.00 127.31 ? 80  GLU C N   1 
ATOM 108  C CA  . GLU A 1 80  ? 179.135 125.953 203.918 1.00 127.31 ? 80  GLU C CA  1 
ATOM 109  C C   . GLU A 1 80  ? 178.525 127.348 203.932 1.00 127.31 ? 80  GLU C C   1 
ATOM 110  O O   . GLU A 1 80  ? 178.805 128.149 204.830 1.00 127.31 ? 80  GLU C O   1 
ATOM 111  C CB  . GLU A 1 80  ? 178.778 125.202 205.200 1.00 127.31 ? 80  GLU C CB  1 
ATOM 112  C CG  . GLU A 1 80  ? 178.594 123.705 205.015 1.00 127.31 ? 80  GLU C CG  1 
ATOM 113  C CD  . GLU A 1 80  ? 178.092 123.021 206.271 1.00 127.31 ? 80  GLU C CD  1 
ATOM 114  O OE1 . GLU A 1 80  ? 177.895 123.716 207.290 1.00 127.31 ? 80  GLU C OE1 1 
ATOM 115  O OE2 . GLU A 1 80  ? 177.895 121.788 206.240 1.00 127.31 ? 80  GLU C OE2 1 
ATOM 116  N N   . GLY A 1 81  ? 177.693 127.637 202.936 1.00 115.39 ? 81  GLY C N   1 
ATOM 117  C CA  . GLY A 1 81  ? 177.024 128.921 202.866 1.00 115.39 ? 81  GLY C CA  1 
ATOM 118  C C   . GLY A 1 81  ? 176.789 129.414 201.453 1.00 115.39 ? 81  GLY C C   1 
ATOM 119  O O   . GLY A 1 81  ? 177.621 129.202 200.565 1.00 115.39 ? 81  GLY C O   1 
ATOM 120  N N   . HIS A 1 82  ? 175.653 130.070 201.235 1.00 100.81 ? 82  HIS C N   1 
ATOM 121  C CA  . HIS A 1 82  ? 175.351 130.673 199.946 1.00 100.81 ? 82  HIS C CA  1 
ATOM 122  C C   . HIS A 1 82  ? 176.342 131.788 199.637 1.00 100.81 ? 82  HIS C C   1 
ATOM 123  O O   . HIS A 1 82  ? 176.733 132.554 200.522 1.00 100.81 ? 82  HIS C O   1 
ATOM 124  C CB  . HIS A 1 82  ? 173.924 131.222 199.940 1.00 100.81 ? 82  HIS C CB  1 
ATOM 125  C CG  . HIS A 1 82  ? 173.404 131.565 198.577 1.00 100.81 ? 82  HIS C CG  1 
ATOM 126  N ND1 . HIS A 1 82  ? 172.094 131.928 198.354 1.00 100.81 ? 82  HIS C ND1 1 
ATOM 127  C CD2 . HIS A 1 82  ? 174.016 131.608 197.370 1.00 100.81 ? 82  HIS C CD2 1 
ATOM 128  C CE1 . HIS A 1 82  ? 171.920 132.180 197.069 1.00 100.81 ? 82  HIS C CE1 1 
ATOM 129  N NE2 . HIS A 1 82  ? 173.073 131.996 196.450 1.00 100.81 ? 82  HIS C NE2 1 
ATOM 130  N N   . CYS A 1 83  ? 176.756 131.864 198.371 1.00 100.24 ? 83  CYS C N   1 
ATOM 131  C CA  . CYS A 1 83  ? 177.649 132.938 197.948 1.00 100.24 ? 83  CYS C CA  1 
ATOM 132  C C   . CYS A 1 83  ? 176.984 134.302 198.091 1.00 100.24 ? 83  CYS C C   1 
ATOM 133  O O   . CYS A 1 83  ? 177.586 135.237 198.630 1.00 100.24 ? 83  CYS C O   1 
ATOM 134  C CB  . CYS A 1 83  ? 178.094 132.709 196.504 1.00 100.24 ? 83  CYS C CB  1 
ATOM 135  S SG  . CYS A 1 83  ? 176.762 132.847 195.293 1.00 100.24 ? 83  CYS C SG  1 
ATOM 136  N N   . LEU A 1 84  ? 175.741 134.433 197.620 1.00 87.91  ? 84  LEU C N   1 
ATOM 137  C CA  . LEU A 1 84  ? 175.070 135.730 197.656 1.00 87.91  ? 84  LEU C CA  1 
ATOM 138  C C   . LEU A 1 84  ? 174.860 136.205 199.089 1.00 87.91  ? 84  LEU C C   1 
ATOM 139  O O   . LEU A 1 84  ? 175.039 137.391 199.389 1.00 87.91  ? 84  LEU C O   1 
ATOM 140  C CB  . LEU A 1 84  ? 173.736 135.652 196.908 1.00 87.91  ? 84  LEU C CB  1 
ATOM 141  C CG  . LEU A 1 84  ? 173.089 136.937 196.377 1.00 87.91  ? 84  LEU C CG  1 
ATOM 142  C CD1 . LEU A 1 84  ? 172.040 136.587 195.342 1.00 87.91  ? 84  LEU C CD1 1 
ATOM 143  C CD2 . LEU A 1 84  ? 172.461 137.780 197.475 1.00 87.91  ? 84  LEU C CD2 1 
ATOM 144  N N   . VAL A 1 85  ? 174.476 135.295 199.986 1.00 88.25  ? 85  VAL C N   1 
ATOM 145  C CA  . VAL A 1 85  ? 174.252 135.670 201.380 1.00 88.25  ? 85  VAL C CA  1 
ATOM 146  C C   . VAL A 1 85  ? 175.542 136.192 202.000 1.00 88.25  ? 85  VAL C C   1 
ATOM 147  O O   . VAL A 1 85  ? 175.532 137.129 202.808 1.00 88.25  ? 85  VAL C O   1 
ATOM 148  C CB  . VAL A 1 85  ? 173.682 134.479 202.172 1.00 88.25  ? 85  VAL C CB  1 
ATOM 149  C CG1 . VAL A 1 85  ? 173.523 134.837 203.640 1.00 88.25  ? 85  VAL C CG1 1 
ATOM 150  C CG2 . VAL A 1 85  ? 172.350 134.046 201.583 1.00 88.25  ? 85  VAL C CG2 1 
ATOM 151  N N   . ARG A 1 86  ? 176.675 135.593 201.629 1.00 96.47  ? 86  ARG C N   1 
ATOM 152  C CA  . ARG A 1 86  ? 177.959 136.045 202.155 1.00 96.47  ? 86  ARG C CA  1 
ATOM 153  C C   . ARG A 1 86  ? 178.260 137.476 201.723 1.00 96.47  ? 86  ARG C C   1 
ATOM 154  O O   . ARG A 1 86  ? 178.672 138.308 202.539 1.00 96.47  ? 86  ARG C O   1 
ATOM 155  C CB  . ARG A 1 86  ? 179.071 135.101 201.701 1.00 96.47  ? 86  ARG C CB  1 
ATOM 156  C CG  . ARG A 1 86  ? 180.442 135.472 202.234 1.00 96.47  ? 86  ARG C CG  1 
ATOM 157  C CD  . ARG A 1 86  ? 181.510 134.520 201.729 1.00 96.47  ? 86  ARG C CD  1 
ATOM 158  N NE  . ARG A 1 86  ? 182.817 134.829 202.295 1.00 96.47  ? 86  ARG C NE  1 
ATOM 159  C CZ  . ARG A 1 86  ? 183.898 134.077 202.139 1.00 96.47  ? 86  ARG C CZ  1 
ATOM 160  N NH1 . ARG A 1 86  ? 183.869 132.965 201.424 1.00 96.47  ? 86  ARG C NH1 1 
ATOM 161  N NH2 . ARG A 1 86  ? 185.037 134.452 202.715 1.00 96.47  ? 86  ARG C NH2 1 
ATOM 162  N N   . VAL A 1 87  ? 178.062 137.780 200.438 1.00 94.28  ? 87  VAL C N   1 
ATOM 163  C CA  . VAL A 1 87  ? 178.330 139.130 199.949 1.00 94.28  ? 87  VAL C CA  1 
ATOM 164  C C   . VAL A 1 87  ? 177.363 140.129 200.568 1.00 94.28  ? 87  VAL C C   1 
ATOM 165  O O   . VAL A 1 87  ? 177.762 141.225 200.980 1.00 94.28  ? 87  VAL C O   1 
ATOM 166  C CB  . VAL A 1 87  ? 178.272 139.172 198.412 1.00 94.28  ? 87  VAL C CB  1 
ATOM 167  C CG1 . VAL A 1 87  ? 178.939 140.436 197.899 1.00 94.28  ? 87  VAL C CG1 1 
ATOM 168  C CG2 . VAL A 1 87  ? 178.945 137.952 197.824 1.00 94.28  ? 87  VAL C CG2 1 
ATOM 169  N N   . VAL A 1 88  ? 176.079 139.774 200.644 1.00 90.37  ? 88  VAL C N   1 
ATOM 170  C CA  . VAL A 1 88  ? 175.087 140.706 201.171 1.00 90.37  ? 88  VAL C CA  1 
ATOM 171  C C   . VAL A 1 88  ? 175.325 140.966 202.654 1.00 90.37  ? 88  VAL C C   1 
ATOM 172  O O   . VAL A 1 88  ? 174.911 142.000 203.189 1.00 90.37  ? 88  VAL C O   1 
ATOM 173  C CB  . VAL A 1 88  ? 173.664 140.185 200.899 1.00 90.37  ? 88  VAL C CB  1 
ATOM 174  C CG1 . VAL A 1 88  ? 173.214 139.241 202.001 1.00 90.37  ? 88  VAL C CG1 1 
ATOM 175  C CG2 . VAL A 1 88  ? 172.694 141.347 200.758 1.00 90.37  ? 88  VAL C CG2 1 
ATOM 176  N N   . ALA A 1 89  ? 175.985 140.033 203.344 1.00 89.72  ? 89  ALA C N   1 
ATOM 177  C CA  . ALA A 1 89  ? 176.323 140.262 204.744 1.00 89.72  ? 89  ALA C CA  1 
ATOM 178  C C   . ALA A 1 89  ? 177.444 141.282 204.879 1.00 89.72  ? 89  ALA C C   1 
ATOM 179  O O   . ALA A 1 89  ? 177.370 142.195 205.709 1.00 89.72  ? 89  ALA C O   1 
ATOM 180  C CB  . ALA A 1 89  ? 176.713 138.945 205.413 1.00 89.72  ? 89  ALA C CB  1 
ATOM 181  N N   . GLU A 1 90  ? 178.494 141.141 204.069 1.00 93.95  ? 90  GLU C N   1 
ATOM 182  C CA  . GLU A 1 90  ? 179.629 142.053 204.155 1.00 93.95  ? 90  GLU C CA  1 
ATOM 183  C C   . GLU A 1 90  ? 179.292 143.403 203.536 1.00 93.95  ? 90  GLU C C   1 
ATOM 184  O O   . GLU A 1 90  ? 179.658 144.450 204.083 1.00 93.95  ? 90  GLU C O   1 
ATOM 185  C CB  . GLU A 1 90  ? 180.851 141.400 203.492 1.00 93.95  ? 90  GLU C CB  1 
ATOM 186  C CG  . GLU A 1 90  ? 182.239 142.056 203.698 1.00 93.95  ? 90  GLU C CG  1 
ATOM 187  C CD  . GLU A 1 90  ? 182.428 143.442 203.093 1.00 93.95  ? 90  GLU C CD  1 
ATOM 188  O OE1 . GLU A 1 90  ? 183.452 144.079 203.416 1.00 93.95  ? 90  GLU C OE1 1 
ATOM 189  O OE2 . GLU A 1 90  ? 181.640 143.859 202.219 1.00 93.95  ? 90  GLU C OE2 1 
ATOM 190  N N   . GLU A 1 91  ? 178.588 143.403 202.402 1.00 88.26  ? 91  GLU C N   1 
ATOM 191  C CA  . GLU A 1 91  ? 178.390 144.642 201.657 1.00 88.26  ? 91  GLU C CA  1 
ATOM 192  C C   . GLU A 1 91  ? 177.359 145.550 202.319 1.00 88.26  ? 91  GLU C C   1 
ATOM 193  O O   . GLU A 1 91  ? 177.476 146.777 202.242 1.00 88.26  ? 91  GLU C O   1 
ATOM 194  C CB  . GLU A 1 91  ? 177.980 144.329 200.217 1.00 88.26  ? 91  GLU C CB  1 
ATOM 195  C CG  . GLU A 1 91  ? 177.894 145.552 199.315 1.00 88.26  ? 91  GLU C CG  1 
ATOM 196  C CD  . GLU A 1 91  ? 179.243 146.216 199.090 1.00 88.26  ? 91  GLU C CD  1 
ATOM 197  O OE1 . GLU A 1 91  ? 180.272 145.513 199.153 1.00 88.26  ? 91  GLU C OE1 1 
ATOM 198  O OE2 . GLU A 1 91  ? 179.274 147.442 198.858 1.00 88.26  ? 91  GLU C OE2 1 
ATOM 199  N N   . LEU A 1 92  ? 176.345 144.974 202.973 1.00 87.57  ? 92  LEU C N   1 
ATOM 200  C CA  . LEU A 1 92  ? 175.318 145.794 203.609 1.00 87.57  ? 92  LEU C CA  1 
ATOM 201  C C   . LEU A 1 92  ? 175.880 146.659 204.727 1.00 87.57  ? 92  LEU C C   1 
ATOM 202  O O   . LEU A 1 92  ? 175.259 147.662 205.093 1.00 87.57  ? 92  LEU C O   1 
ATOM 203  C CB  . LEU A 1 92  ? 174.191 144.915 204.154 1.00 87.57  ? 92  LEU C CB  1 
ATOM 204  C CG  . LEU A 1 92  ? 172.771 145.469 204.025 1.00 87.57  ? 92  LEU C CG  1 
ATOM 205  C CD1 . LEU A 1 92  ? 172.266 145.340 202.597 1.00 87.57  ? 92  LEU C CD1 1 
ATOM 206  C CD2 . LEU A 1 92  ? 171.837 144.763 204.990 1.00 87.57  ? 92  LEU C CD2 1 
ATOM 207  N N   . GLU A 1 93  ? 177.035 146.290 205.285 1.00 87.74  ? 93  GLU C N   1 
ATOM 208  C CA  . GLU A 1 93  ? 177.675 147.135 206.286 1.00 87.74  ? 93  GLU C CA  1 
ATOM 209  C C   . GLU A 1 93  ? 178.121 148.463 205.689 1.00 87.74  ? 93  GLU C C   1 
ATOM 210  O O   . GLU A 1 93  ? 178.052 149.500 206.360 1.00 87.74  ? 93  GLU C O   1 
ATOM 211  C CB  . GLU A 1 93  ? 178.852 146.383 206.916 1.00 87.74  ? 93  GLU C CB  1 
ATOM 212  C CG  . GLU A 1 93  ? 179.906 147.245 207.605 1.00 87.74  ? 93  GLU C CG  1 
ATOM 213  C CD  . GLU A 1 93  ? 180.989 147.726 206.655 1.00 87.74  ? 93  GLU C CD  1 
ATOM 214  O OE1 . GLU A 1 93  ? 181.882 148.479 207.098 1.00 87.74  ? 93  GLU C OE1 1 
ATOM 215  O OE2 . GLU A 1 93  ? 180.950 147.345 205.467 1.00 87.74  ? 93  GLU C OE2 1 
ATOM 216  N N   . ASN A 1 94  ? 178.569 148.457 204.435 1.00 88.15  ? 94  ASN C N   1 
ATOM 217  C CA  . ASN A 1 94  ? 179.077 149.651 203.775 1.00 88.15  ? 94  ASN C CA  1 
ATOM 218  C C   . ASN A 1 94  ? 178.056 150.297 202.847 1.00 88.15  ? 94  ASN C C   1 
ATOM 219  O O   . ASN A 1 94  ? 178.410 151.217 202.102 1.00 88.15  ? 94  ASN C O   1 
ATOM 220  C CB  . ASN A 1 94  ? 180.351 149.320 202.995 1.00 88.15  ? 94  ASN C CB  1 
ATOM 221  C CG  . ASN A 1 94  ? 181.503 150.236 203.348 1.00 88.15  ? 94  ASN C CG  1 
ATOM 222  O OD1 . ASN A 1 94  ? 181.429 151.449 203.153 1.00 88.15  ? 94  ASN C OD1 1 
ATOM 223  N ND2 . ASN A 1 94  ? 182.577 149.659 203.875 1.00 88.15  ? 94  ASN C ND2 1 
ATOM 224  N N   . VAL A 1 95  ? 176.804 149.837 202.864 1.00 80.30  ? 95  VAL C N   1 
ATOM 225  C CA  . VAL A 1 95  ? 175.779 150.444 202.025 1.00 80.30  ? 95  VAL C CA  1 
ATOM 226  C C   . VAL A 1 95  ? 175.540 151.876 202.484 1.00 80.30  ? 95  VAL C C   1 
ATOM 227  O O   . VAL A 1 95  ? 175.777 152.224 203.648 1.00 80.30  ? 95  VAL C O   1 
ATOM 228  C CB  . VAL A 1 95  ? 174.484 149.614 202.062 1.00 80.30  ? 95  VAL C CB  1 
ATOM 229  C CG1 . VAL A 1 95  ? 173.709 149.877 203.344 1.00 80.30  ? 95  VAL C CG1 1 
ATOM 230  C CG2 . VAL A 1 95  ? 173.629 149.906 200.839 1.00 80.30  ? 95  VAL C CG2 1 
ATOM 231  N N   . ARG A 1 96  ? 175.091 152.724 201.562 1.00 85.82  ? 96  ARG C N   1 
ATOM 232  C CA  . ARG A 1 96  ? 174.949 154.145 201.850 1.00 85.82  ? 96  ARG C CA  1 
ATOM 233  C C   . ARG A 1 96  ? 173.502 154.609 201.925 1.00 85.82  ? 96  ARG C C   1 
ATOM 234  O O   . ARG A 1 96  ? 173.193 155.498 202.725 1.00 85.82  ? 96  ARG C O   1 
ATOM 235  C CB  . ARG A 1 96  ? 175.702 154.967 200.798 1.00 85.82  ? 96  ARG C CB  1 
ATOM 236  C CG  . ARG A 1 96  ? 175.523 156.467 200.914 1.00 85.82  ? 96  ARG C CG  1 
ATOM 237  C CD  . ARG A 1 96  ? 176.875 157.153 200.929 1.00 85.82  ? 96  ARG C CD  1 
ATOM 238  N NE  . ARG A 1 96  ? 177.568 156.924 202.192 1.00 85.82  ? 96  ARG C NE  1 
ATOM 239  C CZ  . ARG A 1 96  ? 178.826 156.521 202.297 1.00 85.82  ? 96  ARG C CZ  1 
ATOM 240  N NH1 . ARG A 1 96  ? 179.563 156.267 201.228 1.00 85.82  ? 96  ARG C NH1 1 
ATOM 241  N NH2 . ARG A 1 96  ? 179.358 156.362 203.506 1.00 85.82  ? 96  ARG C NH2 1 
ATOM 242  N N   . ILE A 1 97  ? 172.607 154.025 201.139 1.00 67.58  ? 97  ILE C N   1 
ATOM 243  C CA  . ILE A 1 97  ? 171.198 154.397 201.157 1.00 67.58  ? 97  ILE C CA  1 
ATOM 244  C C   . ILE A 1 97  ? 170.432 153.393 202.003 1.00 67.58  ? 97  ILE C C   1 
ATOM 245  O O   . ILE A 1 97  ? 170.880 152.263 202.226 1.00 67.58  ? 97  ILE C O   1 
ATOM 246  C CB  . ILE A 1 97  ? 170.615 154.476 199.731 1.00 67.58  ? 97  ILE C CB  1 
ATOM 247  C CG1 . ILE A 1 97  ? 170.404 153.071 199.167 1.00 67.58  ? 97  ILE C CG1 1 
ATOM 248  C CG2 . ILE A 1 97  ? 171.532 155.283 198.829 1.00 67.58  ? 97  ILE C CG2 1 
ATOM 249  C CD1 . ILE A 1 97  ? 170.234 153.032 197.666 1.00 67.58  ? 97  ILE C CD1 1 
ATOM 250  N N   . LEU A 1 98  ? 169.269 153.810 202.488 1.00 59.35  ? 98  LEU C N   1 
ATOM 251  C CA  . LEU A 1 98  ? 168.403 152.908 203.236 1.00 59.35  ? 98  LEU C CA  1 
ATOM 252  C C   . LEU A 1 98  ? 167.460 152.199 202.275 1.00 59.35  ? 98  LEU C C   1 
ATOM 253  O O   . LEU A 1 98  ? 166.633 152.859 201.637 1.00 59.35  ? 98  LEU C O   1 
ATOM 254  C CB  . LEU A 1 98  ? 167.610 153.674 204.288 1.00 59.35  ? 98  LEU C CB  1 
ATOM 255  C CG  . LEU A 1 98  ? 166.841 152.847 205.322 1.00 59.35  ? 98  LEU C CG  1 
ATOM 256  C CD1 . LEU A 1 98  ? 166.858 153.544 206.665 1.00 59.35  ? 98  LEU C CD1 1 
ATOM 257  C CD2 . LEU A 1 98  ? 165.406 152.611 204.884 1.00 59.35  ? 98  LEU C CD2 1 
ATOM 258  N N   . PRO A 1 99  ? 167.545 150.880 202.137 1.00 61.01  ? 99  PRO C N   1 
ATOM 259  C CA  . PRO A 1 99  ? 166.671 150.180 201.193 1.00 61.01  ? 99  PRO C CA  1 
ATOM 260  C C   . PRO A 1 99  ? 165.213 150.241 201.622 1.00 61.01  ? 99  PRO C C   1 
ATOM 261  O O   . PRO A 1 99  ? 164.876 150.174 202.805 1.00 61.01  ? 99  PRO C O   1 
ATOM 262  C CB  . PRO A 1 99  ? 167.195 148.741 201.222 1.00 61.01  ? 99  PRO C CB  1 
ATOM 263  C CG  . PRO A 1 99  ? 167.848 148.604 202.547 1.00 61.01  ? 99  PRO C CG  1 
ATOM 264  C CD  . PRO A 1 99  ? 168.396 149.955 202.903 1.00 61.01  ? 99  PRO C CD  1 
ATOM 265  N N   . HIS A 1 100 ? 164.343 150.363 200.627 1.00 72.31  ? 100 HIS C N   1 
ATOM 266  C CA  . HIS A 1 100 ? 162.901 150.366 200.842 1.00 72.31  ? 100 HIS C CA  1 
ATOM 267  C C   . HIS A 1 100 ? 162.199 149.210 200.152 1.00 72.31  ? 100 HIS C C   1 
ATOM 268  O O   . HIS A 1 100 ? 161.399 148.515 200.783 1.00 72.31  ? 100 HIS C O   1 
ATOM 269  C CB  . HIS A 1 100 ? 162.297 151.693 200.360 1.00 72.31  ? 100 HIS C CB  1 
ATOM 270  C CG  . HIS A 1 100 ? 161.248 152.244 201.273 1.00 72.31  ? 100 HIS C CG  1 
ATOM 271  N ND1 . HIS A 1 100 ? 160.452 153.316 200.932 1.00 72.31  ? 100 HIS C ND1 1 
ATOM 272  C CD2 . HIS A 1 100 ? 160.869 151.876 202.519 1.00 72.31  ? 100 HIS C CD2 1 
ATOM 273  C CE1 . HIS A 1 100 ? 159.624 153.581 201.927 1.00 72.31  ? 100 HIS C CE1 1 
ATOM 274  N NE2 . HIS A 1 100 ? 159.857 152.722 202.902 1.00 72.31  ? 100 HIS C NE2 1 
ATOM 275  N N   . THR A 1 101 ? 162.471 148.992 198.867 1.00 59.38  ? 101 THR C N   1 
ATOM 276  C CA  . THR A 1 101 ? 161.990 147.818 198.154 1.00 59.38  ? 101 THR C CA  1 
ATOM 277  C C   . THR A 1 101 ? 163.183 147.163 197.478 1.00 59.38  ? 101 THR C C   1 
ATOM 278  O O   . THR A 1 101 ? 164.031 147.853 196.907 1.00 59.38  ? 101 THR C O   1 
ATOM 279  C CB  . THR A 1 101 ? 160.924 148.170 197.110 1.00 59.38  ? 101 THR C CB  1 
ATOM 280  O OG1 . THR A 1 101 ? 161.560 148.473 195.863 1.00 59.38  ? 101 THR C OG1 1 
ATOM 281  C CG2 . THR A 1 101 ? 160.102 149.371 197.557 1.00 59.38  ? 101 THR C CG2 1 
ATOM 282  N N   . VAL A 1 102 ? 163.244 145.836 197.539 1.00 52.56  ? 102 VAL C N   1 
ATOM 283  C CA  . VAL A 1 102 ? 164.400 145.097 197.045 1.00 52.56  ? 102 VAL C CA  1 
ATOM 284  C C   . VAL A 1 102 ? 163.935 143.960 196.146 1.00 52.56  ? 102 VAL C C   1 
ATOM 285  O O   . VAL A 1 102 ? 162.966 143.258 196.454 1.00 52.56  ? 102 VAL C O   1 
ATOM 286  C CB  . VAL A 1 102 ? 165.274 144.577 198.207 1.00 52.56  ? 102 VAL C CB  1 
ATOM 287  C CG1 . VAL A 1 102 ? 164.499 143.618 199.086 1.00 52.56  ? 102 VAL C CG1 1 
ATOM 288  C CG2 . VAL A 1 102 ? 166.523 143.907 197.669 1.00 52.56  ? 102 VAL C CG2 1 
ATOM 289  N N   . LEU A 1 103 ? 164.622 143.798 195.016 1.00 45.99  ? 103 LEU C N   1 
ATOM 290  C CA  . LEU A 1 103 ? 164.390 142.711 194.071 1.00 45.99  ? 103 LEU C CA  1 
ATOM 291  C C   . LEU A 1 103 ? 165.696 141.948 193.909 1.00 45.99  ? 103 LEU C C   1 
ATOM 292  O O   . LEU A 1 103 ? 166.690 142.507 193.435 1.00 45.99  ? 103 LEU C O   1 
ATOM 293  C CB  . LEU A 1 103 ? 163.905 143.247 192.726 1.00 45.99  ? 103 LEU C CB  1 
ATOM 294  C CG  . LEU A 1 103 ? 163.489 142.195 191.697 1.00 45.99  ? 103 LEU C CG  1 
ATOM 295  C CD1 . LEU A 1 103 ? 162.705 141.079 192.359 1.00 45.99  ? 103 LEU C CD1 1 
ATOM 296  C CD2 . LEU A 1 103 ? 162.690 142.821 190.569 1.00 45.99  ? 103 LEU C CD2 1 
ATOM 297  N N   . TYR A 1 104 ? 165.698 140.677 194.300 1.00 58.26  ? 104 TYR C N   1 
ATOM 298  C CA  . TYR A 1 104 ? 166.888 139.842 194.225 1.00 58.26  ? 104 TYR C CA  1 
ATOM 299  C C   . TYR A 1 104 ? 166.572 138.537 193.510 1.00 58.26  ? 104 TYR C C   1 
ATOM 300  O O   . TYR A 1 104 ? 165.495 137.962 193.696 1.00 58.26  ? 104 TYR C O   1 
ATOM 301  C CB  . TYR A 1 104 ? 167.456 139.568 195.620 1.00 58.26  ? 104 TYR C CB  1 
ATOM 302  C CG  . TYR A 1 104 ? 166.942 138.305 196.268 1.00 58.26  ? 104 TYR C CG  1 
ATOM 303  C CD1 . TYR A 1 104 ? 165.696 138.273 196.872 1.00 58.26  ? 104 TYR C CD1 1 
ATOM 304  C CD2 . TYR A 1 104 ? 167.713 137.152 196.295 1.00 58.26  ? 104 TYR C CD2 1 
ATOM 305  C CE1 . TYR A 1 104 ? 165.227 137.126 197.473 1.00 58.26  ? 104 TYR C CE1 1 
ATOM 306  C CE2 . TYR A 1 104 ? 167.247 135.998 196.891 1.00 58.26  ? 104 TYR C CE2 1 
ATOM 307  C CZ  . TYR A 1 104 ? 166.003 135.991 197.477 1.00 58.26  ? 104 TYR C CZ  1 
ATOM 308  O OH  . TYR A 1 104 ? 165.533 134.846 198.075 1.00 58.26  ? 104 TYR C OH  1 
ATOM 309  N N   . MET A 1 105 ? 167.515 138.083 192.687 1.00 57.55  ? 105 MET C N   1 
ATOM 310  C CA  . MET A 1 105 ? 167.400 136.848 191.926 1.00 57.55  ? 105 MET C CA  1 
ATOM 311  C C   . MET A 1 105 ? 168.662 136.027 192.135 1.00 57.55  ? 105 MET C C   1 
ATOM 312  O O   . MET A 1 105 ? 169.739 136.584 192.364 1.00 57.55  ? 105 MET C O   1 
ATOM 313  C CB  . MET A 1 105 ? 167.207 137.130 190.430 1.00 57.55  ? 105 MET C CB  1 
ATOM 314  C CG  . MET A 1 105 ? 166.517 138.449 190.130 1.00 57.55  ? 105 MET C CG  1 
ATOM 315  S SD  . MET A 1 105 ? 165.938 138.592 188.430 1.00 57.55  ? 105 MET C SD  1 
ATOM 316  C CE  . MET A 1 105 ? 164.458 137.597 188.482 1.00 57.55  ? 105 MET C CE  1 
ATOM 317  N N   . ALA A 1 106 ? 168.532 134.706 192.063 1.00 67.61  ? 106 ALA C N   1 
ATOM 318  C CA  . ALA A 1 106 ? 169.680 133.820 192.193 1.00 67.61  ? 106 ALA C CA  1 
ATOM 319  C C   . ALA A 1 106 ? 169.431 132.584 191.337 1.00 67.61  ? 106 ALA C C   1 
ATOM 320  O O   . ALA A 1 106 ? 168.301 132.307 190.925 1.00 67.61  ? 106 ALA C O   1 
ATOM 321  C CB  . ALA A 1 106 ? 169.940 133.476 193.664 1.00 67.61  ? 106 ALA C CB  1 
ATOM 322  N N   . ASP A 1 107 ? 170.496 131.828 191.076 1.00 91.31  ? 107 ASP C N   1 
ATOM 323  C CA  . ASP A 1 107 ? 170.424 130.702 190.155 1.00 91.31  ? 107 ASP C CA  1 
ATOM 324  C C   . ASP A 1 107 ? 169.773 129.545 190.908 1.00 91.31  ? 107 ASP C C   1 
ATOM 325  O O   . ASP A 1 107 ? 169.662 129.587 192.137 1.00 91.31  ? 107 ASP C O   1 
ATOM 326  C CB  . ASP A 1 107 ? 171.835 130.390 189.619 1.00 91.31  ? 107 ASP C CB  1 
ATOM 327  C CG  . ASP A 1 107 ? 171.941 129.067 188.846 1.00 91.31  ? 107 ASP C CG  1 
ATOM 328  O OD1 . ASP A 1 107 ? 171.132 128.136 189.026 1.00 91.31  ? 107 ASP C OD1 1 
ATOM 329  O OD2 . ASP A 1 107 ? 172.877 128.964 188.027 1.00 91.31  ? 107 ASP C OD2 1 
ATOM 330  N N   . SER A 1 108 ? 169.342 128.508 190.188 1.00 92.72  ? 108 SER C N   1 
ATOM 331  C CA  . SER A 1 108 ? 168.494 127.463 190.750 1.00 92.72  ? 108 SER C CA  1 
ATOM 332  C C   . SER A 1 108 ? 169.302 126.267 191.241 1.00 92.72  ? 108 SER C C   1 
ATOM 333  O O   . SER A 1 108 ? 168.861 125.122 191.108 1.00 92.72  ? 108 SER C O   1 
ATOM 334  C CB  . SER A 1 108 ? 167.447 127.011 189.734 1.00 92.72  ? 108 SER C CB  1 
ATOM 335  O OG  . SER A 1 108 ? 166.402 126.296 190.368 1.00 92.72  ? 108 SER C OG  1 
ATOM 336  N N   . GLU A 1 109 ? 170.492 126.503 191.800 1.00 103.84 ? 109 GLU C N   1 
ATOM 337  C CA  . GLU A 1 109 ? 171.187 125.446 192.527 1.00 103.84 ? 109 GLU C CA  1 
ATOM 338  C C   . GLU A 1 109 ? 171.557 125.917 193.928 1.00 103.84 ? 109 GLU C C   1 
ATOM 339  O O   . GLU A 1 109 ? 172.069 125.136 194.739 1.00 103.84 ? 109 GLU C O   1 
ATOM 340  C CB  . GLU A 1 109 ? 172.439 124.971 191.781 1.00 103.84 ? 109 GLU C CB  1 
ATOM 341  C CG  . GLU A 1 109 ? 173.746 125.631 192.210 1.00 103.84 ? 109 GLU C CG  1 
ATOM 342  C CD  . GLU A 1 109 ? 174.051 126.902 191.456 1.00 103.84 ? 109 GLU C CD  1 
ATOM 343  O OE1 . GLU A 1 109 ? 173.099 127.594 191.048 1.00 103.84 ? 109 GLU C OE1 1 
ATOM 344  O OE2 . GLU A 1 109 ? 175.246 127.203 191.263 1.00 103.84 ? 109 GLU C OE2 1 
ATOM 345  N N   . THR A 1 110 ? 171.279 127.186 194.234 1.00 105.81 ? 110 THR C N   1 
ATOM 346  C CA  . THR A 1 110 ? 171.648 127.759 195.523 1.00 105.81 ? 110 THR C CA  1 
ATOM 347  C C   . THR A 1 110 ? 170.446 127.915 196.448 1.00 105.81 ? 110 THR C C   1 
ATOM 348  O O   . THR A 1 110 ? 170.517 128.677 197.419 1.00 105.81 ? 110 THR C O   1 
ATOM 349  C CB  . THR A 1 110 ? 172.326 129.114 195.335 1.00 105.81 ? 110 THR C CB  1 
ATOM 350  O OG1 . THR A 1 110 ? 171.508 129.946 194.503 1.00 105.81 ? 110 THR C OG1 1 
ATOM 351  C CG2 . THR A 1 110 ? 173.684 128.939 194.681 1.00 105.81 ? 110 THR C CG2 1 
ATOM 352  N N   . PHE A 1 111 ? 169.347 127.220 196.170 1.00 106.51 ? 111 PHE C N   1 
ATOM 353  C CA  . PHE A 1 111 ? 168.178 127.203 197.041 1.00 106.51 ? 111 PHE C CA  1 
ATOM 354  C C   . PHE A 1 111 ? 167.748 125.771 197.304 1.00 106.51 ? 111 PHE C C   1 
ATOM 355  O O   . PHE A 1 111 ? 166.593 125.500 197.644 1.00 106.51 ? 111 PHE C O   1 
ATOM 356  C CB  . PHE A 1 111 ? 167.032 128.017 196.446 1.00 106.51 ? 111 PHE C CB  1 
ATOM 357  C CG  . PHE A 1 111 ? 167.210 129.497 196.586 1.00 106.51 ? 111 PHE C CG  1 
ATOM 358  C CD1 . PHE A 1 111 ? 166.729 130.160 197.702 1.00 106.51 ? 111 PHE C CD1 1 
ATOM 359  C CD2 . PHE A 1 111 ? 167.879 130.222 195.620 1.00 106.51 ? 111 PHE C CD2 1 
ATOM 360  C CE1 . PHE A 1 111 ? 166.894 131.524 197.838 1.00 106.51 ? 111 PHE C CE1 1 
ATOM 361  C CE2 . PHE A 1 111 ? 168.049 131.582 195.754 1.00 106.51 ? 111 PHE C CE2 1 
ATOM 362  C CZ  . PHE A 1 111 ? 167.558 132.235 196.864 1.00 106.51 ? 111 PHE C CZ  1 
ATOM 363  N N   . ILE A 1 112 ? 168.681 124.835 197.148 1.00 126.36 ? 112 ILE C N   1 
ATOM 364  C CA  . ILE A 1 112 ? 168.426 123.422 197.393 1.00 126.36 ? 112 ILE C CA  1 
ATOM 365  C C   . ILE A 1 112 ? 169.493 122.888 198.336 1.00 126.36 ? 112 ILE C C   1 
ATOM 366  O O   . ILE A 1 112 ? 170.689 123.125 198.135 1.00 126.36 ? 112 ILE C O   1 
ATOM 367  C CB  . ILE A 1 112 ? 168.398 122.615 196.081 1.00 126.36 ? 112 ILE C CB  1 
ATOM 368  C CG1 . ILE A 1 112 ? 167.423 123.235 195.076 1.00 126.36 ? 112 ILE C CG1 1 
ATOM 369  C CG2 . ILE A 1 112 ? 168.047 121.162 196.353 1.00 126.36 ? 112 ILE C CG2 1 
ATOM 370  C CD1 . ILE A 1 112 ? 168.083 124.125 194.047 1.00 126.36 ? 112 ILE C CD1 1 
ATOM 371  N N   . SER A 1 113 ? 169.071 122.168 199.373 1.00 140.47 ? 113 SER C N   1 
ATOM 372  C CA  . SER A 1 113 ? 170.027 121.569 200.293 1.00 140.47 ? 113 SER C CA  1 
ATOM 373  C C   . SER A 1 113 ? 169.769 120.077 200.449 1.00 140.47 ? 113 SER C C   1 
ATOM 374  O O   . SER A 1 113 ? 170.713 119.296 200.610 1.00 140.47 ? 113 SER C O   1 
ATOM 375  C CB  . SER A 1 113 ? 169.971 122.267 201.654 1.00 140.47 ? 113 SER C CB  1 
ATOM 376  O OG  . SER A 1 113 ? 169.979 123.676 201.505 1.00 140.47 ? 113 SER C OG  1 
ATOM 377  N N   . LEU A 1 114 ? 168.501 119.665 200.404 1.00 148.81 ? 114 LEU C N   1 
ATOM 378  C CA  . LEU A 1 114 ? 168.164 118.246 200.438 1.00 148.81 ? 114 LEU C CA  1 
ATOM 379  C C   . LEU A 1 114 ? 167.516 117.782 199.136 1.00 148.81 ? 114 LEU C C   1 
ATOM 380  O O   . LEU A 1 114 ? 168.067 116.925 198.439 1.00 148.81 ? 114 LEU C O   1 
ATOM 381  C CB  . LEU A 1 114 ? 167.263 117.972 201.655 1.00 148.81 ? 114 LEU C CB  1 
ATOM 382  C CG  . LEU A 1 114 ? 166.494 116.662 201.846 1.00 148.81 ? 114 LEU C CG  1 
ATOM 383  C CD1 . LEU A 1 114 ? 166.401 116.352 203.328 1.00 148.81 ? 114 LEU C CD1 1 
ATOM 384  C CD2 . LEU A 1 114 ? 165.092 116.760 201.273 1.00 148.81 ? 114 LEU C CD2 1 
ATOM 385  N N   . GLU A 1 115 ? 166.358 118.345 198.785 1.00 145.08 ? 115 GLU C N   1 
ATOM 386  C CA  . GLU A 1 115 ? 165.772 118.157 197.462 1.00 145.08 ? 115 GLU C CA  1 
ATOM 387  C C   . GLU A 1 115 ? 165.157 119.452 196.947 1.00 145.08 ? 115 GLU C C   1 
ATOM 388  O O   . GLU A 1 115 ? 164.864 119.576 195.753 1.00 145.08 ? 115 GLU C O   1 
ATOM 389  C CB  . GLU A 1 115 ? 164.711 117.051 197.470 1.00 145.08 ? 115 GLU C CB  1 
ATOM 390  C CG  . GLU A 1 115 ? 165.204 115.680 197.900 1.00 145.08 ? 115 GLU C CG  1 
ATOM 391  C CD  . GLU A 1 115 ? 164.072 114.691 198.085 1.00 145.08 ? 115 GLU C CD  1 
ATOM 392  O OE1 . GLU A 1 115 ? 163.103 114.744 197.299 1.00 145.08 ? 115 GLU C OE1 1 
ATOM 393  O OE2 . GLU A 1 115 ? 164.150 113.861 199.015 1.00 145.08 ? 115 GLU C OE2 1 
ATOM 394  N N   . GLU A 1 116 ? 164.958 120.419 197.836 1.00 137.12 ? 116 GLU C N   1 
ATOM 395  C CA  . GLU A 1 116 ? 164.221 121.628 197.491 1.00 137.12 ? 116 GLU C CA  1 
ATOM 396  C C   . GLU A 1 116 ? 165.075 122.875 197.668 1.00 137.12 ? 116 GLU C C   1 
ATOM 397  O O   . GLU A 1 116 ? 165.432 123.240 198.787 1.00 137.12 ? 116 GLU C O   1 
ATOM 398  C CB  . GLU A 1 116 ? 162.953 121.739 198.344 1.00 137.12 ? 116 GLU C CB  1 
ATOM 399  C CG  . GLU A 1 116 ? 162.155 120.442 198.499 1.00 137.12 ? 116 GLU C CG  1 
ATOM 400  C CD  . GLU A 1 116 ? 161.482 119.961 197.218 1.00 137.12 ? 116 GLU C CD  1 
ATOM 401  O OE1 . GLU A 1 116 ? 161.792 120.472 196.122 1.00 137.12 ? 116 GLU C OE1 1 
ATOM 402  O OE2 . GLU A 1 116 ? 160.629 119.054 197.314 1.00 137.12 ? 116 GLU C OE2 1 
ATOM 403  N N   . THR A 1 127 ? 165.293 123.816 204.081 1.00 124.53 ? 127 THR C N   1 
ATOM 404  C CA  . THR A 1 127 ? 166.220 123.858 202.955 1.00 124.53 ? 127 THR C CA  1 
ATOM 405  C C   . THR A 1 127 ? 166.046 125.123 202.105 1.00 124.53 ? 127 THR C C   1 
ATOM 406  O O   . THR A 1 127 ? 166.939 125.968 202.067 1.00 124.53 ? 127 THR C O   1 
ATOM 407  C CB  . THR A 1 127 ? 166.089 122.576 202.080 1.00 124.53 ? 127 THR C CB  1 
ATOM 408  O OG1 . THR A 1 127 ? 166.901 122.695 200.903 1.00 124.53 ? 127 THR C OG1 1 
ATOM 409  C CG2 . THR A 1 127 ? 164.633 122.252 201.724 1.00 124.53 ? 127 THR C CG2 1 
ATOM 410  N N   . SER A 1 128 ? 164.906 125.258 201.424 1.00 113.78 ? 128 SER C N   1 
ATOM 411  C CA  . SER A 1 128 ? 164.631 126.482 200.681 1.00 113.78 ? 128 SER C CA  1 
ATOM 412  C C   . SER A 1 128 ? 164.439 127.656 201.629 1.00 113.78 ? 128 SER C C   1 
ATOM 413  O O   . SER A 1 128 ? 164.892 128.773 201.360 1.00 113.78 ? 128 SER C O   1 
ATOM 414  C CB  . SER A 1 128 ? 163.399 126.297 199.795 1.00 113.78 ? 128 SER C CB  1 
ATOM 415  O OG  . SER A 1 128 ? 162.929 127.545 199.317 1.00 113.78 ? 128 SER C OG  1 
ATOM 416  N N   . MET A 1 129 ? 163.759 127.416 202.749 1.00 110.81 ? 129 MET C N   1 
ATOM 417  C CA  . MET A 1 129 ? 163.523 128.446 203.751 1.00 110.81 ? 129 MET C CA  1 
ATOM 418  C C   . MET A 1 129 ? 164.834 128.946 204.343 1.00 110.81 ? 129 MET C C   1 
ATOM 419  O O   . MET A 1 129 ? 165.010 130.153 204.537 1.00 110.81 ? 129 MET C O   1 
ATOM 420  C CB  . MET A 1 129 ? 162.608 127.911 204.855 1.00 110.81 ? 129 MET C CB  1 
ATOM 421  C CG  . MET A 1 129 ? 161.548 126.939 204.360 1.00 110.81 ? 129 MET C CG  1 
ATOM 422  S SD  . MET A 1 129 ? 162.181 125.270 204.103 1.00 110.81 ? 129 MET C SD  1 
ATOM 423  C CE  . MET A 1 129 ? 162.419 124.731 205.794 1.00 110.81 ? 129 MET C CE  1 
ATOM 424  N N   . GLU A 1 130 ? 165.759 128.028 204.625 1.00 111.07 ? 130 GLU C N   1 
ATOM 425  C CA  . GLU A 1 130 ? 167.033 128.380 205.242 1.00 111.07 ? 130 GLU C CA  1 
ATOM 426  C C   . GLU A 1 130 ? 167.780 129.414 204.412 1.00 111.07 ? 130 GLU C C   1 
ATOM 427  O O   . GLU A 1 130 ? 168.268 130.413 204.948 1.00 111.07 ? 130 GLU C O   1 
ATOM 428  C CB  . GLU A 1 130 ? 167.903 127.134 205.433 1.00 111.07 ? 130 GLU C CB  1 
ATOM 429  C CG  . GLU A 1 130 ? 167.594 126.317 206.684 1.00 111.07 ? 130 GLU C CG  1 
ATOM 430  C CD  . GLU A 1 130 ? 166.165 125.806 206.734 1.00 111.07 ? 130 GLU C CD  1 
ATOM 431  O OE1 . GLU A 1 130 ? 165.527 125.689 205.666 1.00 111.07 ? 130 GLU C OE1 1 
ATOM 432  O OE2 . GLU A 1 130 ? 165.680 125.517 207.848 1.00 111.07 ? 130 GLU C OE2 1 
ATOM 433  N N   . THR A 1 131 ? 167.875 129.183 203.102 1.00 101.36 ? 131 THR C N   1 
ATOM 434  C CA  . THR A 1 131 ? 168.528 130.151 202.230 1.00 101.36 ? 131 THR C CA  1 
ATOM 435  C C   . THR A 1 131 ? 167.677 131.407 202.074 1.00 101.36 ? 131 THR C C   1 
ATOM 436  O O   . THR A 1 131 ? 168.195 132.530 202.078 1.00 101.36 ? 131 THR C O   1 
ATOM 437  C CB  . THR A 1 131 ? 168.815 129.519 200.868 1.00 101.36 ? 131 THR C CB  1 
ATOM 438  O OG1 . THR A 1 131 ? 169.707 128.411 201.038 1.00 101.36 ? 131 THR C OG1 1 
ATOM 439  C CG2 . THR A 1 131 ? 169.467 130.531 199.947 1.00 101.36 ? 131 THR C CG2 1 
ATOM 440  N N   . ALA A 1 132 ? 166.362 131.234 201.944 1.00 96.42  ? 132 ALA C N   1 
ATOM 441  C CA  . ALA A 1 132 ? 165.458 132.357 201.723 1.00 96.42  ? 132 ALA C CA  1 
ATOM 442  C C   . ALA A 1 132 ? 165.391 133.277 202.935 1.00 96.42  ? 132 ALA C C   1 
ATOM 443  O O   . ALA A 1 132 ? 165.678 134.474 202.826 1.00 96.42  ? 132 ALA C O   1 
ATOM 444  C CB  . ALA A 1 132 ? 164.057 131.853 201.372 1.00 96.42  ? 132 ALA C CB  1 
ATOM 445  N N   . LEU A 1 133 ? 165.012 132.733 204.092 1.00 97.64  ? 133 LEU C N   1 
ATOM 446  C CA  . LEU A 1 133 ? 164.852 133.540 205.296 1.00 97.64  ? 133 LEU C CA  1 
ATOM 447  C C   . LEU A 1 133 ? 166.170 134.167 205.732 1.00 97.64  ? 133 LEU C C   1 
ATOM 448  O O   . LEU A 1 133 ? 166.172 135.184 206.433 1.00 97.64  ? 133 LEU C O   1 
ATOM 449  C CB  . LEU A 1 133 ? 164.263 132.707 206.436 1.00 97.64  ? 133 LEU C CB  1 
ATOM 450  C CG  . LEU A 1 133 ? 162.978 131.936 206.136 1.00 97.64  ? 133 LEU C CG  1 
ATOM 451  C CD1 . LEU A 1 133 ? 162.821 130.772 207.099 1.00 97.64  ? 133 LEU C CD1 1 
ATOM 452  C CD2 . LEU A 1 133 ? 161.774 132.860 206.205 1.00 97.64  ? 133 LEU C CD2 1 
ATOM 453  N N   . ALA A 1 134 ? 167.292 133.566 205.332 1.00 96.69  ? 134 ALA C N   1 
ATOM 454  C CA  . ALA A 1 134 ? 168.594 134.154 205.627 1.00 96.69  ? 134 ALA C CA  1 
ATOM 455  C C   . ALA A 1 134 ? 168.697 135.556 205.041 1.00 96.69  ? 134 ALA C C   1 
ATOM 456  O O   . ALA A 1 134 ? 169.078 136.508 205.729 1.00 96.69  ? 134 ALA C O   1 
ATOM 457  C CB  . ALA A 1 134 ? 169.710 133.257 205.089 1.00 96.69  ? 134 ALA C CB  1 
ATOM 458  N N   . LEU A 1 135 ? 168.345 135.700 203.762 1.00 89.97  ? 135 LEU C N   1 
ATOM 459  C CA  . LEU A 1 135 ? 168.345 137.021 203.144 1.00 89.97  ? 135 LEU C CA  1 
ATOM 460  C C   . LEU A 1 135 ? 167.161 137.852 203.622 1.00 89.97  ? 135 LEU C C   1 
ATOM 461  O O   . LEU A 1 135 ? 167.214 139.087 203.611 1.00 89.97  ? 135 LEU C O   1 
ATOM 462  C CB  . LEU A 1 135 ? 168.335 136.886 201.622 1.00 89.97  ? 135 LEU C CB  1 
ATOM 463  C CG  . LEU A 1 135 ? 168.664 138.136 200.804 1.00 89.97  ? 135 LEU C CG  1 
ATOM 464  C CD1 . LEU A 1 135 ? 169.680 139.007 201.518 1.00 89.97  ? 135 LEU C CD1 1 
ATOM 465  C CD2 . LEU A 1 135 ? 169.180 137.744 199.433 1.00 89.97  ? 135 LEU C CD2 1 
ATOM 466  N N   . GLU A 1 136 ? 166.085 137.193 204.047 1.00 88.64  ? 136 GLU C N   1 
ATOM 467  C CA  . GLU A 1 136 ? 164.891 137.899 204.497 1.00 88.64  ? 136 GLU C CA  1 
ATOM 468  C C   . GLU A 1 136 ? 165.088 138.479 205.893 1.00 88.64  ? 136 GLU C C   1 
ATOM 469  O O   . GLU A 1 136 ? 164.254 139.256 206.369 1.00 88.64  ? 136 GLU C O   1 
ATOM 470  C CB  . GLU A 1 136 ? 163.681 136.963 204.474 1.00 88.64  ? 136 GLU C CB  1 
ATOM 471  C CG  . GLU A 1 136 ? 162.355 137.662 204.220 1.00 88.64  ? 136 GLU C CG  1 
ATOM 472  C CD  . GLU A 1 136 ? 161.165 136.736 204.385 1.00 88.64  ? 136 GLU C CD  1 
ATOM 473  O OE1 . GLU A 1 136 ? 161.233 135.586 203.905 1.00 88.64  ? 136 GLU C OE1 1 
ATOM 474  O OE2 . GLU A 1 136 ? 160.161 137.159 204.994 1.00 88.64  ? 136 GLU C OE2 1 
ATOM 475  N N   . LYS A 1 137 ? 166.185 138.111 206.555 1.00 93.40  ? 137 LYS C N   1 
ATOM 476  C CA  . LYS A 1 137 ? 166.468 138.567 207.913 1.00 93.40  ? 137 LYS C CA  1 
ATOM 477  C C   . LYS A 1 137 ? 167.376 139.792 207.934 1.00 93.40  ? 137 LYS C C   1 
ATOM 478  O O   . LYS A 1 137 ? 167.148 140.723 208.712 1.00 93.40  ? 137 LYS C O   1 
ATOM 479  C CB  . LYS A 1 137 ? 167.092 137.427 208.729 1.00 93.40  ? 137 LYS C CB  1 
ATOM 480  C CG  . LYS A 1 137 ? 166.079 136.554 209.449 1.00 93.40  ? 137 LYS C CG  1 
ATOM 481  C CD  . LYS A 1 137 ? 166.765 135.468 210.261 1.00 93.40  ? 137 LYS C CD  1 
ATOM 482  C CE  . LYS A 1 137 ? 167.072 134.249 209.407 1.00 93.40  ? 137 LYS C CE  1 
ATOM 483  N NZ  . LYS A 1 137 ? 167.041 132.992 210.203 1.00 93.40  ? 137 LYS C NZ  1 
ATOM 484  N N   . LEU A 1 138 ? 168.413 139.804 207.093 1.00 91.00  ? 138 LEU C N   1 
ATOM 485  C CA  . LEU A 1 138 ? 169.347 140.925 207.064 1.00 91.00  ? 138 LEU C CA  1 
ATOM 486  C C   . LEU A 1 138 ? 168.667 142.220 206.638 1.00 91.00  ? 138 LEU C C   1 
ATOM 487  O O   . LEU A 1 138 ? 168.950 143.292 207.181 1.00 91.00  ? 138 LEU C O   1 
ATOM 488  C CB  . LEU A 1 138 ? 170.516 140.606 206.130 1.00 91.00  ? 138 LEU C CB  1 
ATOM 489  C CG  . LEU A 1 138 ? 171.689 139.823 206.722 1.00 91.00  ? 138 LEU C CG  1 
ATOM 490  C CD1 . LEU A 1 138 ? 171.345 138.359 206.919 1.00 91.00  ? 138 LEU C CD1 1 
ATOM 491  C CD2 . LEU A 1 138 ? 172.905 139.967 205.829 1.00 91.00  ? 138 LEU C CD2 1 
ATOM 492  N N   . PHE A 1 139 ? 167.772 142.137 205.659 1.00 84.25  ? 139 PHE C N   1 
ATOM 493  C CA  . PHE A 1 139 ? 167.107 143.327 205.159 1.00 84.25  ? 139 PHE C CA  1 
ATOM 494  C C   . PHE A 1 139 ? 166.187 143.909 206.233 1.00 84.25  ? 139 PHE C C   1 
ATOM 495  O O   . PHE A 1 139 ? 165.700 143.183 207.105 1.00 84.25  ? 139 PHE C O   1 
ATOM 496  C CB  . PHE A 1 139 ? 166.316 142.991 203.897 1.00 84.25  ? 139 PHE C CB  1 
ATOM 497  C CG  . PHE A 1 139 ? 167.147 142.995 202.648 1.00 84.25  ? 139 PHE C CG  1 
ATOM 498  C CD1 . PHE A 1 139 ? 168.247 143.828 202.536 1.00 84.25  ? 139 PHE C CD1 1 
ATOM 499  C CD2 . PHE A 1 139 ? 166.842 142.153 201.594 1.00 84.25  ? 139 PHE C CD2 1 
ATOM 500  C CE1 . PHE A 1 139 ? 169.017 143.831 201.391 1.00 84.25  ? 139 PHE C CE1 1 
ATOM 501  C CE2 . PHE A 1 139 ? 167.611 142.150 200.448 1.00 84.25  ? 139 PHE C CE2 1 
ATOM 502  C CZ  . PHE A 1 139 ? 168.699 142.991 200.346 1.00 84.25  ? 139 PHE C CZ  1 
ATOM 503  N N   . PRO A 1 140 ? 165.945 145.221 206.202 1.00 96.30  ? 140 PRO C N   1 
ATOM 504  C CA  . PRO A 1 140 ? 165.129 145.848 207.248 1.00 96.30  ? 140 PRO C CA  1 
ATOM 505  C C   . PRO A 1 140 ? 163.708 145.301 207.267 1.00 96.30  ? 140 PRO C C   1 
ATOM 506  O O   . PRO A 1 140 ? 163.178 144.851 206.248 1.00 96.30  ? 140 PRO C O   1 
ATOM 507  C CB  . PRO A 1 140 ? 165.150 147.335 206.875 1.00 96.30  ? 140 PRO C CB  1 
ATOM 508  C CG  . PRO A 1 140 ? 166.330 147.500 205.986 1.00 96.30  ? 140 PRO C CG  1 
ATOM 509  C CD  . PRO A 1 140 ? 166.491 146.208 205.256 1.00 96.30  ? 140 PRO C CD  1 
ATOM 510  N N   . LYS A 1 141 ? 163.098 145.333 208.454 1.00 104.27 ? 141 LYS C N   1 
ATOM 511  C CA  . LYS A 1 141 ? 161.738 144.827 208.607 1.00 104.27 ? 141 LYS C CA  1 
ATOM 512  C C   . LYS A 1 141 ? 160.749 145.626 207.766 1.00 104.27 ? 141 LYS C C   1 
ATOM 513  O O   . LYS A 1 141 ? 159.858 145.051 207.131 1.00 104.27 ? 141 LYS C O   1 
ATOM 514  C CB  . LYS A 1 141 ? 161.332 144.853 210.082 1.00 104.27 ? 141 LYS C CB  1 
ATOM 515  C CG  . LYS A 1 141 ? 160.092 144.029 210.420 1.00 104.27 ? 141 LYS C CG  1 
ATOM 516  C CD  . LYS A 1 141 ? 160.036 142.707 209.662 1.00 104.27 ? 141 LYS C CD  1 
ATOM 517  C CE  . LYS A 1 141 ? 161.119 141.740 210.127 1.00 104.27 ? 141 LYS C CE  1 
ATOM 518  N NZ  . LYS A 1 141 ? 161.271 140.588 209.194 1.00 104.27 ? 141 LYS C NZ  1 
ATOM 519  N N   . GLN A 1 142 ? 160.887 146.952 207.750 1.00 102.03 ? 142 GLN C N   1 
ATOM 520  C CA  . GLN A 1 142 ? 160.009 147.791 206.945 1.00 102.03 ? 142 GLN C CA  1 
ATOM 521  C C   . GLN A 1 142 ? 160.253 147.641 205.450 1.00 102.03 ? 142 GLN C C   1 
ATOM 522  O O   . GLN A 1 142 ? 159.373 147.996 204.659 1.00 102.03 ? 142 GLN C O   1 
ATOM 523  C CB  . GLN A 1 142 ? 160.165 149.268 207.335 1.00 102.03 ? 142 GLN C CB  1 
ATOM 524  C CG  . GLN A 1 142 ? 159.682 149.664 208.740 1.00 102.03 ? 142 GLN C CG  1 
ATOM 525  C CD  . GLN A 1 142 ? 160.451 149.018 209.888 1.00 102.03 ? 142 GLN C CD  1 
ATOM 526  O OE1 . GLN A 1 142 ? 161.257 148.108 209.692 1.00 102.03 ? 142 GLN C OE1 1 
ATOM 527  N NE2 . GLN A 1 142 ? 160.202 149.501 211.100 1.00 102.03 ? 142 GLN C NE2 1 
ATOM 528  N N   . CYS A 1 143 ? 161.413 147.130 205.047 1.00 84.74  ? 143 CYS C N   1 
ATOM 529  C CA  . CYS A 1 143 ? 161.713 146.963 203.634 1.00 84.74  ? 143 CYS C CA  1 
ATOM 530  C C   . CYS A 1 143 ? 160.842 145.871 203.023 1.00 84.74  ? 143 CYS C C   1 
ATOM 531  O O   . CYS A 1 143 ? 160.435 144.918 203.693 1.00 84.74  ? 143 CYS C O   1 
ATOM 532  C CB  . CYS A 1 143 ? 163.190 146.624 203.439 1.00 84.74  ? 143 CYS C CB  1 
ATOM 533  S SG  . CYS A 1 143 ? 163.710 146.508 201.715 1.00 84.74  ? 143 CYS C SG  1 
ATOM 534  N N   . GLN A 1 144 ? 160.557 146.019 201.733 1.00 69.91  ? 144 GLN C N   1 
ATOM 535  C CA  . GLN A 1 144 ? 159.718 145.081 200.999 1.00 69.91  ? 144 GLN C CA  1 
ATOM 536  C C   . GLN A 1 144 ? 160.606 144.202 200.127 1.00 69.91  ? 144 GLN C C   1 
ATOM 537  O O   . GLN A 1 144 ? 161.393 144.713 199.323 1.00 69.91  ? 144 GLN C O   1 
ATOM 538  C CB  . GLN A 1 144 ? 158.689 145.828 200.152 1.00 69.91  ? 144 GLN C CB  1 
ATOM 539  C CG  . GLN A 1 144 ? 157.330 145.163 200.108 1.00 69.91  ? 144 GLN C CG  1 
ATOM 540  C CD  . GLN A 1 144 ? 156.201 146.167 200.037 1.00 69.91  ? 144 GLN C CD  1 
ATOM 541  O OE1 . GLN A 1 144 ? 156.432 147.366 199.879 1.00 69.91  ? 144 GLN C OE1 1 
ATOM 542  N NE2 . GLN A 1 144 ? 154.971 145.685 200.158 1.00 69.91  ? 144 GLN C NE2 1 
ATOM 543  N N   . VAL A 1 145 ? 160.476 142.887 200.285 1.00 64.31  ? 145 VAL C N   1 
ATOM 544  C CA  . VAL A 1 145 ? 161.357 141.919 199.642 1.00 64.31  ? 145 VAL C CA  1 
ATOM 545  C C   . VAL A 1 145 ? 160.533 141.027 198.727 1.00 64.31  ? 145 VAL C C   1 
ATOM 546  O O   . VAL A 1 145 ? 159.523 140.454 199.153 1.00 64.31  ? 145 VAL C O   1 
ATOM 547  C CB  . VAL A 1 145 ? 162.114 141.074 200.682 1.00 64.31  ? 145 VAL C CB  1 
ATOM 548  C CG1 . VAL A 1 145 ? 163.230 140.288 200.016 1.00 64.31  ? 145 VAL C CG1 1 
ATOM 549  C CG2 . VAL A 1 145 ? 162.660 141.957 201.791 1.00 64.31  ? 145 VAL C CG2 1 
ATOM 550  N N   . LEU A 1 146 ? 160.966 140.906 197.475 1.00 55.30  ? 146 LEU C N   1 
ATOM 551  C CA  . LEU A 1 146 ? 160.410 139.948 196.531 1.00 55.30  ? 146 LEU C CA  1 
ATOM 552  C C   . LEU A 1 146 ? 161.489 138.937 196.174 1.00 55.30  ? 146 LEU C C   1 
ATOM 553  O O   . LEU A 1 146 ? 162.576 139.311 195.723 1.00 55.30  ? 146 LEU C O   1 
ATOM 554  C CB  . LEU A 1 146 ? 159.887 140.643 195.266 1.00 55.30  ? 146 LEU C CB  1 
ATOM 555  C CG  . LEU A 1 146 ? 159.039 139.818 194.292 1.00 55.30  ? 146 LEU C CG  1 
ATOM 556  C CD1 . LEU A 1 146 ? 158.072 140.719 193.548 1.00 55.30  ? 146 LEU C CD1 1 
ATOM 557  C CD2 . LEU A 1 146 ? 159.891 139.044 193.301 1.00 55.30  ? 146 LEU C CD2 1 
ATOM 558  N N   . GLY A 1 147 ? 161.184 137.657 196.363 1.00 63.63  ? 147 GLY C N   1 
ATOM 559  C CA  . GLY A 1 147 ? 162.175 136.619 196.158 1.00 63.63  ? 147 GLY C CA  1 
ATOM 560  C C   . GLY A 1 147 ? 161.872 135.684 195.008 1.00 63.63  ? 147 GLY C C   1 
ATOM 561  O O   . GLY A 1 147 ? 160.919 134.903 195.069 1.00 63.63  ? 147 GLY C O   1 
ATOM 562  N N   . ILE A 1 148 ? 162.694 135.738 193.965 1.00 57.68  ? 148 ILE C N   1 
ATOM 563  C CA  . ILE A 1 148 ? 162.457 135.016 192.723 1.00 57.68  ? 148 ILE C CA  1 
ATOM 564  C C   . ILE A 1 148 ? 163.735 134.295 192.316 1.00 57.68  ? 148 ILE C C   1 
ATOM 565  O O   . ILE A 1 148 ? 164.825 134.873 192.359 1.00 57.68  ? 148 ILE C O   1 
ATOM 566  C CB  . ILE A 1 148 ? 161.980 135.981 191.619 1.00 57.68  ? 148 ILE C CB  1 
ATOM 567  C CG1 . ILE A 1 148 ? 162.007 135.314 190.248 1.00 57.68  ? 148 ILE C CG1 1 
ATOM 568  C CG2 . ILE A 1 148 ? 162.807 137.250 191.631 1.00 57.68  ? 148 ILE C CG2 1 
ATOM 569  C CD1 . ILE A 1 148 ? 161.214 136.072 189.214 1.00 57.68  ? 148 ILE C CD1 1 
ATOM 570  N N   . VAL A 1 149 ? 163.597 133.029 191.929 1.00 67.14  ? 149 VAL C N   1 
ATOM 571  C CA  . VAL A 1 149 ? 164.722 132.181 191.550 1.00 67.14  ? 149 VAL C CA  1 
ATOM 572  C C   . VAL A 1 149 ? 164.568 131.797 190.086 1.00 67.14  ? 149 VAL C C   1 
ATOM 573  O O   . VAL A 1 149 ? 163.495 131.348 189.664 1.00 67.14  ? 149 VAL C O   1 
ATOM 574  C CB  . VAL A 1 149 ? 164.807 130.929 192.437 1.00 67.14  ? 149 VAL C CB  1 
ATOM 575  C CG1 . VAL A 1 149 ? 166.102 130.180 192.173 1.00 67.14  ? 149 VAL C CG1 1 
ATOM 576  C CG2 . VAL A 1 149 ? 164.697 131.312 193.902 1.00 67.14  ? 149 VAL C CG2 1 
ATOM 577  N N   . THR A 1 150 ? 165.640 131.969 189.313 1.00 66.70  ? 150 THR C N   1 
ATOM 578  C CA  . THR A 1 150 ? 165.622 131.722 187.877 1.00 66.70  ? 150 THR C CA  1 
ATOM 579  C C   . THR A 1 150 ? 166.778 130.808 187.490 1.00 66.70  ? 150 THR C C   1 
ATOM 580  O O   . THR A 1 150 ? 167.791 130.762 188.199 1.00 66.70  ? 150 THR C O   1 
ATOM 581  C CB  . THR A 1 150 ? 165.720 133.037 187.102 1.00 66.70  ? 150 THR C CB  1 
ATOM 582  O OG1 . THR A 1 150 ? 167.025 133.597 187.283 1.00 66.70  ? 150 THR C OG1 1 
ATOM 583  C CG2 . THR A 1 150 ? 164.689 134.032 187.598 1.00 66.70  ? 150 THR C CG2 1 
ATOM 584  N N   . PRO A 1 151 ? 166.677 130.068 186.380 1.00 61.17  ? 151 PRO C N   1 
ATOM 585  C CA  . PRO A 1 151 ? 167.817 129.254 185.942 1.00 61.17  ? 151 PRO C CA  1 
ATOM 586  C C   . PRO A 1 151 ? 168.799 130.051 185.101 1.00 61.17  ? 151 PRO C C   1 
ATOM 587  O O   . PRO A 1 151 ? 168.917 129.831 183.892 1.00 61.17  ? 151 PRO C O   1 
ATOM 588  C CB  . PRO A 1 151 ? 167.155 128.136 185.129 1.00 61.17  ? 151 PRO C CB  1 
ATOM 589  C CG  . PRO A 1 151 ? 165.885 128.736 184.618 1.00 61.17  ? 151 PRO C CG  1 
ATOM 590  C CD  . PRO A 1 151 ? 165.515 129.915 185.487 1.00 61.17  ? 151 PRO C CD  1 
ATOM 591  N N   . GLY A 1 152 ? 169.511 130.977 185.734 1.00 55.58  ? 152 GLY C N   1 
ATOM 592  C CA  . GLY A 1 152 ? 170.460 131.818 185.033 1.00 55.58  ? 152 GLY C CA  1 
ATOM 593  C C   . GLY A 1 152 ? 170.368 133.270 185.452 1.00 55.58  ? 152 GLY C C   1 
ATOM 594  O O   . GLY A 1 152 ? 169.280 133.852 185.465 1.00 55.58  ? 152 GLY C O   1 
ATOM 595  N N   . ILE A 1 153 ? 171.508 133.866 185.790 1.00 57.43  ? 153 ILE C N   1 
ATOM 596  C CA  . ILE A 1 153 ? 171.578 135.248 186.252 1.00 57.43  ? 153 ILE C CA  1 
ATOM 597  C C   . ILE A 1 153 ? 172.526 136.012 185.342 1.00 57.43  ? 153 ILE C C   1 
ATOM 598  O O   . ILE A 1 153 ? 173.642 135.554 185.078 1.00 57.43  ? 153 ILE C O   1 
ATOM 599  C CB  . ILE A 1 153 ? 172.063 135.341 187.711 1.00 57.43  ? 153 ILE C CB  1 
ATOM 600  C CG1 . ILE A 1 153 ? 171.185 134.508 188.648 1.00 57.43  ? 153 ILE C CG1 1 
ATOM 601  C CG2 . ILE A 1 153 ? 172.106 136.787 188.159 1.00 57.43  ? 153 ILE C CG2 1 
ATOM 602  C CD1 . ILE A 1 153 ? 169.708 134.756 188.497 1.00 57.43  ? 153 ILE C CD1 1 
ATOM 603  N N   . VAL A 1 154 ? 172.088 137.172 184.862 1.00 54.57  ? 154 VAL C N   1 
ATOM 604  C CA  . VAL A 1 154 ? 172.916 138.062 184.056 1.00 54.57  ? 154 VAL C CA  1 
ATOM 605  C C   . VAL A 1 154 ? 172.994 139.397 184.781 1.00 54.57  ? 154 VAL C C   1 
ATOM 606  O O   . VAL A 1 154 ? 171.960 140.022 185.046 1.00 54.57  ? 154 VAL C O   1 
ATOM 607  C CB  . VAL A 1 154 ? 172.340 138.224 182.641 1.00 54.57  ? 154 VAL C CB  1 
ATOM 608  C CG1 . VAL A 1 154 ? 173.146 139.228 181.846 1.00 54.57  ? 154 VAL C CG1 1 
ATOM 609  C CG2 . VAL A 1 154 ? 172.294 136.886 181.942 1.00 54.57  ? 154 VAL C CG2 1 
ATOM 610  N N   . VAL A 1 155 ? 174.209 139.842 185.098 1.00 56.02  ? 155 VAL C N   1 
ATOM 611  C CA  . VAL A 1 155 ? 174.373 140.864 186.129 1.00 56.02  ? 155 VAL C CA  1 
ATOM 612  C C   . VAL A 1 155 ? 175.589 141.732 185.828 1.00 56.02  ? 155 VAL C C   1 
ATOM 613  O O   . VAL A 1 155 ? 176.571 141.268 185.242 1.00 56.02  ? 155 VAL C O   1 
ATOM 614  C CB  . VAL A 1 155 ? 174.502 140.212 187.519 1.00 56.02  ? 155 VAL C CB  1 
ATOM 615  C CG1 . VAL A 1 155 ? 175.682 139.254 187.548 1.00 56.02  ? 155 VAL C CG1 1 
ATOM 616  C CG2 . VAL A 1 155 ? 174.621 141.261 188.595 1.00 56.02  ? 155 VAL C CG2 1 
ATOM 617  N N   . THR A 1 156 ? 175.506 143.004 186.227 1.00 58.78  ? 156 THR C N   1 
ATOM 618  C CA  . THR A 1 156 ? 176.637 143.927 186.227 1.00 58.78  ? 156 THR C CA  1 
ATOM 619  C C   . THR A 1 156 ? 177.274 143.952 187.615 1.00 58.78  ? 156 THR C C   1 
ATOM 620  O O   . THR A 1 156 ? 176.554 144.016 188.616 1.00 58.78  ? 156 THR C O   1 
ATOM 621  C CB  . THR A 1 156 ? 176.170 145.330 185.841 1.00 58.78  ? 156 THR C CB  1 
ATOM 622  O OG1 . THR A 1 156 ? 175.370 145.260 184.654 1.00 58.78  ? 156 THR C OG1 1 
ATOM 623  C CG2 . THR A 1 156 ? 177.349 146.254 185.587 1.00 58.78  ? 156 THR C CG2 1 
ATOM 624  N N   . PRO A 1 157 ? 178.598 143.895 187.720 1.00 66.70  ? 157 PRO C N   1 
ATOM 625  C CA  . PRO A 1 157 ? 179.245 143.891 189.037 1.00 66.70  ? 157 PRO C CA  1 
ATOM 626  C C   . PRO A 1 157 ? 179.186 145.260 189.707 1.00 66.70  ? 157 PRO C C   1 
ATOM 627  O O   . PRO A 1 157 ? 178.702 146.243 189.144 1.00 66.70  ? 157 PRO C O   1 
ATOM 628  C CB  . PRO A 1 157 ? 180.695 143.487 188.729 1.00 66.70  ? 157 PRO C CB  1 
ATOM 629  C CG  . PRO A 1 157 ? 180.715 143.106 187.269 1.00 66.70  ? 157 PRO C CG  1 
ATOM 630  C CD  . PRO A 1 157 ? 179.581 143.815 186.630 1.00 66.70  ? 157 PRO C CD  1 
ATOM 631  N N   . MET A 1 158 ? 179.700 145.306 190.937 1.00 75.35  ? 158 MET C N   1 
ATOM 632  C CA  . MET A 1 158 ? 179.646 146.518 191.740 1.00 75.35  ? 158 MET C CA  1 
ATOM 633  C C   . MET A 1 158 ? 180.527 147.609 191.134 1.00 75.35  ? 158 MET C C   1 
ATOM 634  O O   . MET A 1 158 ? 181.216 147.415 190.131 1.00 75.35  ? 158 MET C O   1 
ATOM 635  C CB  . MET A 1 158 ? 180.096 146.277 193.189 1.00 75.35  ? 158 MET C CB  1 
ATOM 636  C CG  . MET A 1 158 ? 179.170 145.458 194.102 1.00 75.35  ? 158 MET C CG  1 
ATOM 637  S SD  . MET A 1 158 ? 178.574 143.814 193.635 1.00 75.35  ? 158 MET C SD  1 
ATOM 638  C CE  . MET A 1 158 ? 180.022 143.081 192.869 1.00 75.35  ? 158 MET C CE  1 
ATOM 639  N N   . GLY A 1 159 ? 180.497 148.778 191.770 1.00 73.95  ? 159 GLY C N   1 
ATOM 640  C CA  . GLY A 1 159 ? 181.366 149.867 191.377 1.00 73.95  ? 159 GLY C CA  1 
ATOM 641  C C   . GLY A 1 159 ? 180.637 151.004 190.697 1.00 73.95  ? 159 GLY C C   1 
ATOM 642  O O   . GLY A 1 159 ? 179.768 151.644 191.296 1.00 73.95  ? 159 GLY C O   1 
ATOM 643  N N   . SER A 1 160 ? 180.983 151.265 189.443 1.00 66.96  ? 160 SER C N   1 
ATOM 644  C CA  . SER A 1 160 ? 180.365 152.320 188.659 1.00 66.96  ? 160 SER C CA  1 
ATOM 645  C C   . SER A 1 160 ? 179.435 151.718 187.614 1.00 66.96  ? 160 SER C C   1 
ATOM 646  O O   . SER A 1 160 ? 179.188 150.510 187.583 1.00 66.96  ? 160 SER C O   1 
ATOM 647  C CB  . SER A 1 160 ? 181.429 153.197 187.989 1.00 66.96  ? 160 SER C CB  1 
ATOM 648  O OG  . SER A 1 160 ? 180.843 154.064 187.035 1.00 66.96  ? 160 SER C OG  1 
ATOM 649  N N   . GLY A 1 161 ? 178.910 152.587 186.758 1.00 60.84  ? 161 GLY C N   1 
ATOM 650  C CA  . GLY A 1 161 ? 178.054 152.170 185.672 1.00 60.84  ? 161 GLY C CA  1 
ATOM 651  C C   . GLY A 1 161 ? 178.770 151.713 184.425 1.00 60.84  ? 161 GLY C C   1 
ATOM 652  O O   . GLY A 1 161 ? 178.117 151.391 183.430 1.00 60.84  ? 161 GLY C O   1 
ATOM 653  N N   . SER A 1 162 ? 180.100 151.676 184.444 1.00 63.97  ? 162 SER C N   1 
ATOM 654  C CA  . SER A 1 162 ? 180.889 151.309 183.278 1.00 63.97  ? 162 SER C CA  1 
ATOM 655  C C   . SER A 1 162 ? 181.401 149.877 183.322 1.00 63.97  ? 162 SER C C   1 
ATOM 656  O O   . SER A 1 162 ? 182.180 149.488 182.447 1.00 63.97  ? 162 SER C O   1 
ATOM 657  C CB  . SER A 1 162 ? 182.072 152.268 183.120 1.00 63.97  ? 162 SER C CB  1 
ATOM 658  O OG  . SER A 1 162 ? 182.505 152.317 181.772 1.00 63.97  ? 162 SER C OG  1 
ATOM 659  N N   . ASN A 1 163 ? 180.997 149.089 184.314 1.00 66.73  ? 163 ASN C N   1 
ATOM 660  C CA  . ASN A 1 163 ? 181.440 147.706 184.379 1.00 66.73  ? 163 ASN C CA  1 
ATOM 661  C C   . ASN A 1 163 ? 180.854 146.899 183.225 1.00 66.73  ? 163 ASN C C   1 
ATOM 662  O O   . ASN A 1 163 ? 179.674 147.013 182.881 1.00 66.73  ? 163 ASN C O   1 
ATOM 663  C CB  . ASN A 1 163 ? 181.046 147.072 185.712 1.00 66.73  ? 163 ASN C CB  1 
ATOM 664  C CG  . ASN A 1 163 ? 182.084 147.292 186.791 1.00 66.73  ? 163 ASN C CG  1 
ATOM 665  O OD1 . ASN A 1 163 ? 182.234 146.473 187.696 1.00 66.73  ? 163 ASN C OD1 1 
ATOM 666  N ND2 . ASN A 1 163 ? 182.812 148.397 186.697 1.00 66.73  ? 163 ASN C ND2 1 
ATOM 667  N N   . ARG A 1 164 ? 181.699 146.074 182.628 1.00 67.62  ? 164 ARG C N   1 
ATOM 668  C CA  . ARG A 1 164 ? 181.279 145.195 181.544 1.00 67.62  ? 164 ARG C CA  1 
ATOM 669  C C   . ARG A 1 164 ? 180.361 144.108 182.083 1.00 67.62  ? 164 ARG C C   1 
ATOM 670  O O   . ARG A 1 164 ? 180.743 143.390 183.014 1.00 67.62  ? 164 ARG C O   1 
ATOM 671  C CB  . ARG A 1 164 ? 182.487 144.569 180.865 1.00 67.62  ? 164 ARG C CB  1 
ATOM 672  C CG  . ARG A 1 164 ? 182.153 143.462 179.891 1.00 67.62  ? 164 ARG C CG  1 
ATOM 673  C CD  . ARG A 1 164 ? 183.407 142.938 179.218 1.00 67.62  ? 164 ARG C CD  1 
ATOM 674  N NE  . ARG A 1 164 ? 183.098 142.265 177.964 1.00 67.62  ? 164 ARG C NE  1 
ATOM 675  C CZ  . ARG A 1 164 ? 182.887 140.960 177.856 1.00 67.62  ? 164 ARG C CZ  1 
ATOM 676  N NH1 . ARG A 1 164 ? 183.022 140.150 178.893 1.00 67.62  ? 164 ARG C NH1 1 
ATOM 677  N NH2 . ARG A 1 164 ? 182.542 140.453 176.678 1.00 67.62  ? 164 ARG C NH2 1 
ATOM 678  N N   . PRO A 1 165 ? 179.154 143.964 181.538 1.00 62.96  ? 165 PRO C N   1 
ATOM 679  C CA  . PRO A 1 165 ? 178.222 142.974 182.078 1.00 62.96  ? 165 PRO C CA  1 
ATOM 680  C C   . PRO A 1 165 ? 178.722 141.569 181.807 1.00 62.96  ? 165 PRO C C   1 
ATOM 681  O O   . PRO A 1 165 ? 179.337 141.293 180.776 1.00 62.96  ? 165 PRO C O   1 
ATOM 682  C CB  . PRO A 1 165 ? 176.916 143.258 181.327 1.00 62.96  ? 165 PRO C CB  1 
ATOM 683  C CG  . PRO A 1 165 ? 177.166 144.493 180.508 1.00 62.96  ? 165 PRO C CG  1 
ATOM 684  C CD  . PRO A 1 165 ? 178.637 144.583 180.312 1.00 62.96  ? 165 PRO C CD  1 
ATOM 685  N N   . GLN A 1 166 ? 178.450 140.676 182.749 1.00 74.66  ? 166 GLN C N   1 
ATOM 686  C CA  . GLN A 1 166 ? 178.871 139.289 182.655 1.00 74.66  ? 166 GLN C CA  1 
ATOM 687  C C   . GLN A 1 166 ? 177.629 138.413 182.627 1.00 74.66  ? 166 GLN C C   1 
ATOM 688  O O   . GLN A 1 166 ? 176.769 138.518 183.508 1.00 74.66  ? 166 GLN C O   1 
ATOM 689  C CB  . GLN A 1 166 ? 179.791 138.914 183.821 1.00 74.66  ? 166 GLN C CB  1 
ATOM 690  C CG  . GLN A 1 166 ? 179.805 137.440 184.163 1.00 74.66  ? 166 GLN C CG  1 
ATOM 691  C CD  . GLN A 1 166 ? 180.481 137.152 185.490 1.00 74.66  ? 166 GLN C CD  1 
ATOM 692  O OE1 . GLN A 1 166 ? 180.097 137.694 186.528 1.00 74.66  ? 166 GLN C OE1 1 
ATOM 693  N NE2 . GLN A 1 166 ? 181.499 136.300 185.462 1.00 74.66  ? 166 GLN C NE2 1 
ATOM 694  N N   . GLU A 1 167 ? 177.524 137.578 181.598 1.00 76.88  ? 167 GLU C N   1 
ATOM 695  C CA  . GLU A 1 167 ? 176.368 136.718 181.375 1.00 76.88  ? 167 GLU C CA  1 
ATOM 696  C C   . GLU A 1 167 ? 176.684 135.345 181.958 1.00 76.88  ? 167 GLU C C   1 
ATOM 697  O O   . GLU A 1 167 ? 177.592 134.659 181.479 1.00 76.88  ? 167 GLU C O   1 
ATOM 698  C CB  . GLU A 1 167 ? 176.063 136.638 179.880 1.00 76.88  ? 167 GLU C CB  1 
ATOM 699  C CG  . GLU A 1 167 ? 174.714 136.071 179.499 1.00 76.88  ? 167 GLU C CG  1 
ATOM 700  C CD  . GLU A 1 167 ? 174.365 136.370 178.053 1.00 76.88  ? 167 GLU C CD  1 
ATOM 701  O OE1 . GLU A 1 167 ? 173.394 135.786 177.533 1.00 76.88  ? 167 GLU C OE1 1 
ATOM 702  O OE2 . GLU A 1 167 ? 175.064 137.199 177.434 1.00 76.88  ? 167 GLU C OE2 1 
ATOM 703  N N   . ILE A 1 168 ? 175.944 134.940 182.986 1.00 73.67  ? 168 ILE C N   1 
ATOM 704  C CA  . ILE A 1 168 ? 176.241 133.716 183.719 1.00 73.67  ? 168 ILE C CA  1 
ATOM 705  C C   . ILE A 1 168 ? 175.161 132.690 183.407 1.00 73.67  ? 168 ILE C C   1 
ATOM 706  O O   . ILE A 1 168 ? 173.991 132.884 183.756 1.00 73.67  ? 168 ILE C O   1 
ATOM 707  C CB  . ILE A 1 168 ? 176.328 133.954 185.238 1.00 73.67  ? 168 ILE C CB  1 
ATOM 708  C CG1 . ILE A 1 168 ? 177.444 134.928 185.597 1.00 73.67  ? 168 ILE C CG1 1 
ATOM 709  C CG2 . ILE A 1 168 ? 176.615 132.664 185.961 1.00 73.67  ? 168 ILE C CG2 1 
ATOM 710  C CD1 . ILE A 1 168 ? 176.954 136.340 185.726 1.00 73.67  ? 168 ILE C CD1 1 
ATOM 711  N N   . GLU A 1 169 ? 175.557 131.599 182.755 1.00 80.96  ? 169 GLU C N   1 
ATOM 712  C CA  . GLU A 1 169 ? 174.730 130.403 182.639 1.00 80.96  ? 169 GLU C CA  1 
ATOM 713  C C   . GLU A 1 169 ? 174.956 129.586 183.907 1.00 80.96  ? 169 GLU C C   1 
ATOM 714  O O   . GLU A 1 169 ? 175.411 130.145 184.906 1.00 80.96  ? 169 GLU C O   1 
ATOM 715  C CB  . GLU A 1 169 ? 175.061 129.617 181.367 1.00 80.96  ? 169 GLU C CB  1 
ATOM 716  C CG  . GLU A 1 169 ? 173.946 128.682 180.894 1.00 80.96  ? 169 GLU C CG  1 
ATOM 717  C CD  . GLU A 1 169 ? 173.614 128.850 179.422 1.00 80.96  ? 169 GLU C CD  1 
ATOM 718  O OE1 . GLU A 1 169 ? 172.725 128.124 178.928 1.00 80.96  ? 169 GLU C OE1 1 
ATOM 719  O OE2 . GLU A 1 169 ? 174.231 129.712 178.761 1.00 80.96  ? 169 GLU C OE2 1 
ATOM 720  N N   . ILE A 1 170 ? 174.609 128.297 183.904 1.00 89.00  ? 170 ILE C N   1 
ATOM 721  C CA  . ILE A 1 170 ? 174.641 127.461 185.104 1.00 89.00  ? 170 ILE C CA  1 
ATOM 722  C C   . ILE A 1 170 ? 175.894 127.745 185.927 1.00 89.00  ? 170 ILE C C   1 
ATOM 723  O O   . ILE A 1 170 ? 177.019 127.701 185.416 1.00 89.00  ? 170 ILE C O   1 
ATOM 724  C CB  . ILE A 1 170 ? 174.556 125.967 184.734 1.00 89.00  ? 170 ILE C CB  1 
ATOM 725  C CG1 . ILE A 1 170 ? 174.838 125.083 185.954 1.00 89.00  ? 170 ILE C CG1 1 
ATOM 726  C CG2 . ILE A 1 170 ? 175.508 125.638 183.590 1.00 89.00  ? 170 ILE C CG2 1 
ATOM 727  C CD1 . ILE A 1 170 ? 173.885 125.303 187.117 1.00 89.00  ? 170 ILE C CD1 1 
ATOM 728  N N   . GLY A 1 171 ? 175.695 128.053 187.208 1.00 91.44  ? 171 GLY C N   1 
ATOM 729  C CA  . GLY A 1 171 ? 176.747 128.550 188.073 1.00 91.44  ? 171 GLY C CA  1 
ATOM 730  C C   . GLY A 1 171 ? 176.198 129.544 189.078 1.00 91.44  ? 171 GLY C C   1 
ATOM 731  O O   . GLY A 1 171 ? 175.334 130.358 188.737 1.00 91.44  ? 171 GLY C O   1 
ATOM 732  N N   . GLU A 1 172 ? 176.687 129.496 190.315 1.00 89.97  ? 172 GLU C N   1 
ATOM 733  C CA  . GLU A 1 172 ? 176.105 130.270 191.411 1.00 89.97  ? 172 GLU C CA  1 
ATOM 734  C C   . GLU A 1 172 ? 176.389 131.751 191.203 1.00 89.97  ? 172 GLU C C   1 
ATOM 735  O O   . GLU A 1 172 ? 177.538 132.193 191.252 1.00 89.97  ? 172 GLU C O   1 
ATOM 736  C CB  . GLU A 1 172 ? 176.643 129.790 192.754 1.00 89.97  ? 172 GLU C CB  1 
ATOM 737  C CG  . GLU A 1 172 ? 178.099 129.367 192.744 1.00 89.97  ? 172 GLU C CG  1 
ATOM 738  C CD  . GLU A 1 172 ? 178.544 128.805 194.080 1.00 89.97  ? 172 GLU C CD  1 
ATOM 739  O OE1 . GLU A 1 172 ? 179.492 129.359 194.675 1.00 89.97  ? 172 GLU C OE1 1 
ATOM 740  O OE2 . GLU A 1 172 ? 177.941 127.812 194.538 1.00 89.97  ? 172 GLU C OE2 1 
ATOM 741  N N   . SER A 1 173 ? 175.330 132.523 190.969 1.00 73.23  ? 173 SER C N   1 
ATOM 742  C CA  . SER A 1 173 ? 175.422 133.970 190.855 1.00 73.23  ? 173 SER C CA  1 
ATOM 743  C C   . SER A 1 173 ? 174.079 134.577 191.226 1.00 73.23  ? 173 SER C C   1 
ATOM 744  O O   . SER A 1 173 ? 173.053 133.894 191.255 1.00 73.23  ? 173 SER C O   1 
ATOM 745  C CB  . SER A 1 173 ? 175.824 134.408 189.444 1.00 73.23  ? 173 SER C CB  1 
ATOM 746  O OG  . SER A 1 173 ? 175.083 133.695 188.472 1.00 73.23  ? 173 SER C OG  1 
ATOM 747  N N   . GLY A 1 174 ? 174.096 135.873 191.518 1.00 65.85  ? 174 GLY C N   1 
ATOM 748  C CA  . GLY A 1 174 ? 172.875 136.578 191.848 1.00 65.85  ? 174 GLY C CA  1 
ATOM 749  C C   . GLY A 1 174 ? 173.101 138.035 192.186 1.00 65.85  ? 174 GLY C C   1 
ATOM 750  O O   . GLY A 1 174 ? 174.222 138.433 192.517 1.00 65.85  ? 174 GLY C O   1 
ATOM 751  N N   . PHE A 1 175 ? 172.047 138.841 192.109 1.00 55.10  ? 175 PHE C N   1 
ATOM 752  C CA  . PHE A 1 175 ? 172.135 140.259 192.416 1.00 55.10  ? 175 PHE C CA  1 
ATOM 753  C C   . PHE A 1 175 ? 170.962 140.671 193.290 1.00 55.10  ? 175 PHE C C   1 
ATOM 754  O O   . PHE A 1 175 ? 169.911 140.026 193.292 1.00 55.10  ? 175 PHE C O   1 
ATOM 755  C CB  . PHE A 1 175 ? 172.146 141.128 191.151 1.00 55.10  ? 175 PHE C CB  1 
ATOM 756  C CG  . PHE A 1 175 ? 170.948 140.936 190.266 1.00 55.10  ? 175 PHE C CG  1 
ATOM 757  C CD1 . PHE A 1 175 ? 170.815 139.805 189.482 1.00 55.10  ? 175 PHE C CD1 1 
ATOM 758  C CD2 . PHE A 1 175 ? 169.952 141.893 190.219 1.00 55.10  ? 175 PHE C CD2 1 
ATOM 759  C CE1 . PHE A 1 175 ? 169.714 139.636 188.672 1.00 55.10  ? 175 PHE C CE1 1 
ATOM 760  C CE2 . PHE A 1 175 ? 168.850 141.725 189.412 1.00 55.10  ? 175 PHE C CE2 1 
ATOM 761  C CZ  . PHE A 1 175 ? 168.734 140.599 188.635 1.00 55.10  ? 175 PHE C CZ  1 
ATOM 762  N N   . ALA A 1 176 ? 171.159 141.752 194.038 1.00 56.69  ? 176 ALA C N   1 
ATOM 763  C CA  . ALA A 1 176 ? 170.105 142.372 194.828 1.00 56.69  ? 176 ALA C CA  1 
ATOM 764  C C   . ALA A 1 176 ? 170.047 143.851 194.482 1.00 56.69  ? 176 ALA C C   1 
ATOM 765  O O   . ALA A 1 176 ? 171.081 144.526 194.461 1.00 56.69  ? 176 ALA C O   1 
ATOM 766  C CB  . ALA A 1 176 ? 170.345 142.181 196.329 1.00 56.69  ? 176 ALA C CB  1 
ATOM 767  N N   . LEU A 1 177 ? 168.846 144.350 194.207 1.00 47.40  ? 177 LEU C N   1 
ATOM 768  C CA  . LEU A 1 177 ? 168.634 145.739 193.823 1.00 47.40  ? 177 LEU C CA  1 
ATOM 769  C C   . LEU A 1 177 ? 168.002 146.481 194.992 1.00 47.40  ? 177 LEU C C   1 
ATOM 770  O O   . LEU A 1 177 ? 166.920 146.107 195.452 1.00 47.40  ? 177 LEU C O   1 
ATOM 771  C CB  . LEU A 1 177 ? 167.743 145.832 192.585 1.00 47.40  ? 177 LEU C CB  1 
ATOM 772  C CG  . LEU A 1 177 ? 168.355 145.347 191.274 1.00 47.40  ? 177 LEU C CG  1 
ATOM 773  C CD1 . LEU A 1 177 ? 167.366 145.498 190.135 1.00 47.40  ? 177 LEU C CD1 1 
ATOM 774  C CD2 . LEU A 1 177 ? 169.625 146.115 190.983 1.00 47.40  ? 177 LEU C CD2 1 
ATOM 775  N N   . LEU A 1 178 ? 168.666 147.534 195.459 1.00 49.89  ? 178 LEU C N   1 
ATOM 776  C CA  . LEU A 1 178 ? 168.194 148.325 196.590 1.00 49.89  ? 178 LEU C CA  1 
ATOM 777  C C   . LEU A 1 178 ? 167.588 149.621 196.064 1.00 49.89  ? 178 LEU C C   1 
ATOM 778  O O   . LEU A 1 178 ? 168.305 150.482 195.545 1.00 49.89  ? 178 LEU C O   1 
ATOM 779  C CB  . LEU A 1 178 ? 169.331 148.604 197.568 1.00 49.89  ? 178 LEU C CB  1 
ATOM 780  C CG  . LEU A 1 178 ? 170.151 147.378 197.967 1.00 49.89  ? 178 LEU C CG  1 
ATOM 781  C CD1 . LEU A 1 178 ? 171.266 147.760 198.922 1.00 49.89  ? 178 LEU C CD1 1 
ATOM 782  C CD2 . LEU A 1 178 ? 169.254 146.320 198.585 1.00 49.89  ? 178 LEU C CD2 1 
ATOM 783  N N   . PHE A 1 179 ? 166.268 149.755 196.201 1.00 53.61  ? 179 PHE C N   1 
ATOM 784  C CA  . PHE A 1 179 ? 165.566 150.960 195.783 1.00 53.61  ? 179 PHE C CA  1 
ATOM 785  C C   . PHE A 1 179 ? 165.333 151.855 196.987 1.00 53.61  ? 179 PHE C C   1 
ATOM 786  O O   . PHE A 1 179 ? 164.630 151.444 197.924 1.00 53.61  ? 179 PHE C O   1 
ATOM 787  C CB  . PHE A 1 179 ? 164.237 150.608 195.125 1.00 53.61  ? 179 PHE C CB  1 
ATOM 788  C CG  . PHE A 1 179 ? 164.375 149.889 193.814 1.00 53.61  ? 179 PHE C CG  1 
ATOM 789  C CD1 . PHE A 1 179 ? 165.218 150.373 192.830 1.00 53.61  ? 179 PHE C CD1 1 
ATOM 790  C CD2 . PHE A 1 179 ? 163.659 148.733 193.564 1.00 53.61  ? 179 PHE C CD2 1 
ATOM 791  C CE1 . PHE A 1 179 ? 165.345 149.714 191.624 1.00 53.61  ? 179 PHE C CE1 1 
ATOM 792  C CE2 . PHE A 1 179 ? 163.782 148.072 192.360 1.00 53.61  ? 179 PHE C CE2 1 
ATOM 793  C CZ  . PHE A 1 179 ? 164.625 148.563 191.389 1.00 53.61  ? 179 PHE C CZ  1 
ATOM 794  N N   . PRO A 1 180 ? 165.887 153.064 197.017 1.00 62.59  ? 180 PRO C N   1 
ATOM 795  C CA  . PRO A 1 180 ? 165.669 153.947 198.167 1.00 62.59  ? 180 PRO C CA  1 
ATOM 796  C C   . PRO A 1 180 ? 164.351 154.694 198.077 1.00 62.59  ? 180 PRO C C   1 
ATOM 797  O O   . PRO A 1 180 ? 163.608 154.537 197.104 1.00 62.59  ? 180 PRO C O   1 
ATOM 798  C CB  . PRO A 1 180 ? 166.861 154.904 198.091 1.00 62.59  ? 180 PRO C CB  1 
ATOM 799  C CG  . PRO A 1 180 ? 167.120 155.020 196.624 1.00 62.59  ? 180 PRO C CG  1 
ATOM 800  C CD  . PRO A 1 180 ? 166.756 153.686 196.003 1.00 62.59  ? 180 PRO C CD  1 
ATOM 801  N N   . GLN A 1 181 ? 164.052 155.511 199.084 1.00 79.04  ? 181 GLN C N   1 
ATOM 802  C CA  . GLN A 1 181 ? 162.835 156.317 199.072 1.00 79.04  ? 181 GLN C CA  1 
ATOM 803  C C   . GLN A 1 181 ? 163.002 157.469 198.090 1.00 79.04  ? 181 GLN C C   1 
ATOM 804  O O   . GLN A 1 181 ? 163.786 158.392 198.329 1.00 79.04  ? 181 GLN C O   1 
ATOM 805  C CB  . GLN A 1 181 ? 162.525 156.832 200.475 1.00 79.04  ? 181 GLN C CB  1 
ATOM 806  C CG  . GLN A 1 181 ? 161.179 157.542 200.613 1.00 79.04  ? 181 GLN C CG  1 
ATOM 807  C CD  . GLN A 1 181 ? 159.983 156.602 200.560 1.00 79.04  ? 181 GLN C CD  1 
ATOM 808  O OE1 . GLN A 1 181 ? 159.919 155.691 199.733 1.00 79.04  ? 181 GLN C OE1 1 
ATOM 809  N NE2 . GLN A 1 181 ? 159.025 156.824 201.452 1.00 79.04  ? 181 GLN C NE2 1 
ATOM 810  N N   . ILE A 1 182 ? 162.262 157.418 196.987 1.00 77.35  ? 182 ILE C N   1 
ATOM 811  C CA  . ILE A 1 182 ? 162.338 158.412 195.925 1.00 77.35  ? 182 ILE C CA  1 
ATOM 812  C C   . ILE A 1 182 ? 161.022 159.177 195.888 1.00 77.35  ? 182 ILE C C   1 
ATOM 813  O O   . ILE A 1 182 ? 159.943 158.573 195.897 1.00 77.35  ? 182 ILE C O   1 
ATOM 814  C CB  . ILE A 1 182 ? 162.654 157.756 194.568 1.00 77.35  ? 182 ILE C CB  1 
ATOM 815  C CG1 . ILE A 1 182 ? 162.565 158.776 193.430 1.00 77.35  ? 182 ILE C CG1 1 
ATOM 816  C CG2 . ILE A 1 182 ? 161.761 156.547 194.329 1.00 77.35  ? 182 ILE C CG2 1 
ATOM 817  C CD1 . ILE A 1 182 ? 163.611 159.858 193.493 1.00 77.35  ? 182 ILE C CD1 1 
ATOM 818  N N   . GLU A 1 183 ? 161.114 160.505 195.865 1.00 78.12  ? 183 GLU C N   1 
ATOM 819  C CA  . GLU A 1 183 ? 159.924 161.344 195.923 1.00 78.12  ? 183 GLU C CA  1 
ATOM 820  C C   . GLU A 1 183 ? 159.117 161.229 194.635 1.00 78.12  ? 183 GLU C C   1 
ATOM 821  O O   . GLU A 1 183 ? 159.659 161.362 193.534 1.00 78.12  ? 183 GLU C O   1 
ATOM 822  C CB  . GLU A 1 183 ? 160.319 162.800 196.168 1.00 78.12  ? 183 GLU C CB  1 
ATOM 823  C CG  . GLU A 1 183 ? 160.639 163.125 197.618 1.00 78.12  ? 183 GLU C CG  1 
ATOM 824  C CD  . GLU A 1 183 ? 159.573 163.979 198.274 1.00 78.12  ? 183 GLU C CD  1 
ATOM 825  O OE1 . GLU A 1 183 ? 159.798 164.445 199.410 1.00 78.12  ? 183 GLU C OE1 1 
ATOM 826  O OE2 . GLU A 1 183 ? 158.510 164.187 197.652 1.00 78.12  ? 183 GLU C OE2 1 
ATOM 827  N N   . GLY A 1 184 ? 157.817 160.983 194.778 1.00 66.14  ? 184 GLY C N   1 
ATOM 828  C CA  . GLY A 1 184 ? 156.911 160.938 193.651 1.00 66.14  ? 184 GLY C CA  1 
ATOM 829  C C   . GLY A 1 184 ? 156.818 159.608 192.937 1.00 66.14  ? 184 GLY C C   1 
ATOM 830  O O   . GLY A 1 184 ? 155.995 159.475 192.023 1.00 66.14  ? 184 GLY C O   1 
ATOM 831  N N   . ILE A 1 185 ? 157.629 158.623 193.313 1.00 58.00  ? 185 ILE C N   1 
ATOM 832  C CA  . ILE A 1 185 ? 157.611 157.299 192.701 1.00 58.00  ? 185 ILE C CA  1 
ATOM 833  C C   . ILE A 1 185 ? 157.265 156.289 193.784 1.00 58.00  ? 185 ILE C C   1 
ATOM 834  O O   . ILE A 1 185 ? 157.903 156.266 194.843 1.00 58.00  ? 185 ILE C O   1 
ATOM 835  C CB  . ILE A 1 185 ? 158.958 156.948 192.039 1.00 58.00  ? 185 ILE C CB  1 
ATOM 836  C CG1 . ILE A 1 185 ? 159.062 157.535 190.627 1.00 58.00  ? 185 ILE C CG1 1 
ATOM 837  C CG2 . ILE A 1 185 ? 159.150 155.442 191.982 1.00 58.00  ? 185 ILE C CG2 1 
ATOM 838  C CD1 . ILE A 1 185 ? 159.106 159.046 190.557 1.00 58.00  ? 185 ILE C CD1 1 
ATOM 839  N N   . LYS A 1 186 ? 156.255 155.463 193.525 1.00 46.40  ? 186 LYS C N   1 
ATOM 840  C CA  . LYS A 1 186 ? 155.792 154.477 194.488 1.00 46.40  ? 186 LYS C CA  1 
ATOM 841  C C   . LYS A 1 186 ? 155.767 153.101 193.838 1.00 46.40  ? 186 LYS C C   1 
ATOM 842  O O   . LYS A 1 186 ? 155.187 152.923 192.762 1.00 46.40  ? 186 LYS C O   1 
ATOM 843  C CB  . LYS A 1 186 ? 154.404 154.853 195.024 1.00 46.40  ? 186 LYS C CB  1 
ATOM 844  C CG  . LYS A 1 186 ? 153.966 154.073 196.252 1.00 46.40  ? 186 LYS C CG  1 
ATOM 845  C CD  . LYS A 1 186 ? 152.839 153.113 195.930 1.00 46.40  ? 186 LYS C CD  1 
ATOM 846  C CE  . LYS A 1 186 ? 152.260 152.487 197.187 1.00 46.40  ? 186 LYS C CE  1 
ATOM 847  N NZ  . LYS A 1 186 ? 150.858 152.032 196.979 1.00 46.40  ? 186 LYS C NZ  1 
ATOM 848  N N   . ILE A 1 187 ? 156.400 152.133 194.497 1.00 42.17  ? 187 ILE C N   1 
ATOM 849  C CA  . ILE A 1 187 ? 156.552 150.775 193.984 1.00 42.17  ? 187 ILE C CA  1 
ATOM 850  C C   . ILE A 1 187 ? 155.890 149.825 194.969 1.00 42.17  ? 187 ILE C C   1 
ATOM 851  O O   . ILE A 1 187 ? 156.142 149.908 196.177 1.00 42.17  ? 187 ILE C O   1 
ATOM 852  C CB  . ILE A 1 187 ? 158.029 150.398 193.787 1.00 42.17  ? 187 ILE C CB  1 
ATOM 853  C CG1 . ILE A 1 187 ? 158.717 151.406 192.867 1.00 42.17  ? 187 ILE C CG1 1 
ATOM 854  C CG2 . ILE A 1 187 ? 158.150 148.993 193.234 1.00 42.17  ? 187 ILE C CG2 1 
ATOM 855  C CD1 . ILE A 1 187 ? 160.202 151.538 193.113 1.00 42.17  ? 187 ILE C CD1 1 
ATOM 856  N N   . GLN A 1 188 ? 155.045 148.924 194.461 1.00 44.10  ? 188 GLN C N   1 
ATOM 857  C CA  . GLN A 1 188 ? 154.308 148.015 195.326 1.00 44.10  ? 188 GLN C CA  1 
ATOM 858  C C   . GLN A 1 188 ? 154.290 146.621 194.707 1.00 44.10  ? 188 GLN C C   1 
ATOM 859  O O   . GLN A 1 188 ? 153.848 146.461 193.556 1.00 44.10  ? 188 GLN C O   1 
ATOM 860  C CB  . GLN A 1 188 ? 152.881 148.517 195.553 1.00 44.10  ? 188 GLN C CB  1 
ATOM 861  C CG  . GLN A 1 188 ? 152.142 148.891 194.280 1.00 44.10  ? 188 GLN C CG  1 
ATOM 862  C CD  . GLN A 1 188 ? 152.219 150.365 193.951 1.00 44.10  ? 188 GLN C CD  1 
ATOM 863  O OE1 . GLN A 1 188 ? 153.306 150.929 193.840 1.00 44.10  ? 188 GLN C OE1 1 
ATOM 864  N NE2 . GLN A 1 188 ? 151.064 151.000 193.796 1.00 44.10  ? 188 GLN C NE2 1 
ATOM 865  N N   . PRO A 1 189 ? 154.764 145.605 195.422 1.00 47.64  ? 189 PRO C N   1 
ATOM 866  C CA  . PRO A 1 189 ? 154.695 144.240 194.894 1.00 47.64  ? 189 PRO C CA  1 
ATOM 867  C C   . PRO A 1 189 ? 153.259 143.744 194.824 1.00 47.64  ? 189 PRO C C   1 
ATOM 868  O O   . PRO A 1 189 ? 152.348 144.299 195.442 1.00 47.64  ? 189 PRO C O   1 
ATOM 869  C CB  . PRO A 1 189 ? 155.511 143.427 195.903 1.00 47.64  ? 189 PRO C CB  1 
ATOM 870  C CG  . PRO A 1 189 ? 156.426 144.418 196.533 1.00 47.64  ? 189 PRO C CG  1 
ATOM 871  C CD  . PRO A 1 189 ? 155.651 145.701 196.591 1.00 47.64  ? 189 PRO C CD  1 
ATOM 872  N N   . PHE A 1 190 ? 153.063 142.679 194.050 1.00 50.55  ? 190 PHE C N   1 
ATOM 873  C CA  . PHE A 1 190 ? 151.761 142.038 193.946 1.00 50.55  ? 190 PHE C CA  1 
ATOM 874  C C   . PHE A 1 190 ? 151.962 140.542 193.764 1.00 50.55  ? 190 PHE C C   1 
ATOM 875  O O   . PHE A 1 190 ? 153.011 140.104 193.285 1.00 50.55  ? 190 PHE C O   1 
ATOM 876  C CB  . PHE A 1 190 ? 150.934 142.621 192.793 1.00 50.55  ? 190 PHE C CB  1 
ATOM 877  C CG  . PHE A 1 190 ? 151.492 142.334 191.427 1.00 50.55  ? 190 PHE C CG  1 
ATOM 878  C CD1 . PHE A 1 190 ? 151.112 141.201 190.728 1.00 50.55  ? 190 PHE C CD1 1 
ATOM 879  C CD2 . PHE A 1 190 ? 152.391 143.204 190.837 1.00 50.55  ? 190 PHE C CD2 1 
ATOM 880  C CE1 . PHE A 1 190 ? 151.621 140.941 189.472 1.00 50.55  ? 190 PHE C CE1 1 
ATOM 881  C CE2 . PHE A 1 190 ? 152.903 142.948 189.582 1.00 50.55  ? 190 PHE C CE2 1 
ATOM 882  C CZ  . PHE A 1 190 ? 152.517 141.815 188.900 1.00 50.55  ? 190 PHE C CZ  1 
ATOM 883  N N   . HIS A 1 191 ? 150.951 139.766 194.146 1.00 62.07  ? 191 HIS C N   1 
ATOM 884  C CA  . HIS A 1 191 ? 151.042 138.309 194.102 1.00 62.07  ? 191 HIS C CA  1 
ATOM 885  C C   . HIS A 1 191 ? 149.639 137.740 193.955 1.00 62.07  ? 191 HIS C C   1 
ATOM 886  O O   . HIS A 1 191 ? 148.769 138.012 194.787 1.00 62.07  ? 191 HIS C O   1 
ATOM 887  C CB  . HIS A 1 191 ? 151.723 137.768 195.356 1.00 62.07  ? 191 HIS C CB  1 
ATOM 888  C CG  . HIS A 1 191 ? 151.731 136.274 195.448 1.00 62.07  ? 191 HIS C CG  1 
ATOM 889  N ND1 . HIS A 1 191 ? 151.802 135.605 196.650 1.00 62.07  ? 191 HIS C ND1 1 
ATOM 890  C CD2 . HIS A 1 191 ? 151.668 135.320 194.490 1.00 62.07  ? 191 HIS C CD2 1 
ATOM 891  C CE1 . HIS A 1 191 ? 151.789 134.303 196.428 1.00 62.07  ? 191 HIS C CE1 1 
ATOM 892  N NE2 . HIS A 1 191 ? 151.707 134.103 195.125 1.00 62.07  ? 191 HIS C NE2 1 
ATOM 893  N N   . PHE A 1 192 ? 149.423 136.957 192.903 1.00 66.05  ? 192 PHE C N   1 
ATOM 894  C CA  . PHE A 1 192 ? 148.164 136.254 192.680 1.00 66.05  ? 192 PHE C CA  1 
ATOM 895  C C   . PHE A 1 192 ? 148.468 134.760 192.675 1.00 66.05  ? 192 PHE C C   1 
ATOM 896  O O   . PHE A 1 192 ? 148.977 134.224 191.687 1.00 66.05  ? 192 PHE C O   1 
ATOM 897  C CB  . PHE A 1 192 ? 147.510 136.694 191.376 1.00 66.05  ? 192 PHE C CB  1 
ATOM 898  C CG  . PHE A 1 192 ? 147.414 138.180 191.221 1.00 66.05  ? 192 PHE C CG  1 
ATOM 899  C CD1 . PHE A 1 192 ? 146.812 138.952 192.195 1.00 66.05  ? 192 PHE C CD1 1 
ATOM 900  C CD2 . PHE A 1 192 ? 147.917 138.803 190.095 1.00 66.05  ? 192 PHE C CD2 1 
ATOM 901  C CE1 . PHE A 1 192 ? 146.723 140.321 192.053 1.00 66.05  ? 192 PHE C CE1 1 
ATOM 902  C CE2 . PHE A 1 192 ? 147.829 140.170 189.947 1.00 66.05  ? 192 PHE C CE2 1 
ATOM 903  C CZ  . PHE A 1 192 ? 147.230 140.930 190.927 1.00 66.05  ? 192 PHE C CZ  1 
ATOM 904  N N   . ILE A 1 193 ? 148.157 134.091 193.782 1.00 70.55  ? 193 ILE C N   1 
ATOM 905  C CA  . ILE A 1 193 ? 148.390 132.659 193.911 1.00 70.55  ? 193 ILE C CA  1 
ATOM 906  C C   . ILE A 1 193 ? 147.393 131.927 193.022 1.00 70.55  ? 193 ILE C C   1 
ATOM 907  O O   . ILE A 1 193 ? 146.312 132.448 192.729 1.00 70.55  ? 193 ILE C O   1 
ATOM 908  C CB  . ILE A 1 193 ? 148.273 132.213 195.381 1.00 70.55  ? 193 ILE C CB  1 
ATOM 909  C CG1 . ILE A 1 193 ? 148.851 130.811 195.573 1.00 70.55  ? 193 ILE C CG1 1 
ATOM 910  C CG2 . ILE A 1 193 ? 146.826 132.268 195.846 1.00 70.55  ? 193 ILE C CG2 1 
ATOM 911  C CD1 . ILE A 1 193 ? 150.260 130.668 195.054 1.00 70.55  ? 193 ILE C CD1 1 
ATOM 912  N N   . LYS A 1 194 ? 147.746 130.727 192.573 1.00 88.27  ? 194 LYS C N   1 
ATOM 913  C CA  . LYS A 1 194 ? 146.838 129.924 191.773 1.00 88.27  ? 194 LYS C CA  1 
ATOM 914  C C   . LYS A 1 194 ? 145.828 129.244 192.702 1.00 88.27  ? 194 LYS C C   1 
ATOM 915  O O   . LYS A 1 194 ? 145.887 129.400 193.927 1.00 88.27  ? 194 LYS C O   1 
ATOM 916  C CB  . LYS A 1 194 ? 147.636 128.924 190.923 1.00 88.27  ? 194 LYS C CB  1 
ATOM 917  C CG  . LYS A 1 194 ? 146.826 128.266 189.809 1.00 88.27  ? 194 LYS C CG  1 
ATOM 918  C CD  . LYS A 1 194 ? 147.563 127.111 189.165 1.00 88.27  ? 194 LYS C CD  1 
ATOM 919  C CE  . LYS A 1 194 ? 146.854 126.651 187.904 1.00 88.27  ? 194 LYS C CE  1 
ATOM 920  N NZ  . LYS A 1 194 ? 146.103 127.757 187.250 1.00 88.27  ? 194 LYS C NZ  1 
ATOM 921  N N   . ASP A 1 195 ? 144.902 128.482 192.130 1.00 109.67 ? 195 ASP C N   1 
ATOM 922  C CA  . ASP A 1 195 ? 143.828 127.854 192.883 1.00 109.67 ? 195 ASP C CA  1 
ATOM 923  C C   . ASP A 1 195 ? 143.589 126.432 192.394 1.00 109.67 ? 195 ASP C C   1 
ATOM 924  O O   . ASP A 1 195 ? 143.806 126.136 191.212 1.00 109.67 ? 195 ASP C O   1 
ATOM 925  C CB  . ASP A 1 195 ? 142.547 128.679 192.752 1.00 109.67 ? 195 ASP C CB  1 
ATOM 926  C CG  . ASP A 1 195 ? 142.223 129.026 191.307 1.00 109.67 ? 195 ASP C CG  1 
ATOM 927  O OD1 . ASP A 1 195 ? 142.999 128.637 190.408 1.00 109.67 ? 195 ASP C OD1 1 
ATOM 928  O OD2 . ASP A 1 195 ? 141.195 129.689 191.064 1.00 109.67 ? 195 ASP C OD2 1 
ATOM 929  N N   . PRO A 1 196 ? 143.161 125.525 193.265 1.00 117.11 ? 196 PRO C N   1 
ATOM 930  C CA  . PRO A 1 196 ? 142.668 124.229 192.785 1.00 117.11 ? 196 PRO C CA  1 
ATOM 931  C C   . PRO A 1 196 ? 141.375 124.409 192.011 1.00 117.11 ? 196 PRO C C   1 
ATOM 932  O O   . PRO A 1 196 ? 141.211 123.875 190.910 1.00 117.11 ? 196 PRO C O   1 
ATOM 933  C CB  . PRO A 1 196 ? 142.456 123.428 194.077 1.00 117.11 ? 196 PRO C CB  1 
ATOM 934  C CG  . PRO A 1 196 ? 143.296 124.126 195.105 1.00 117.11 ? 196 PRO C CG  1 
ATOM 935  C CD  . PRO A 1 196 ? 143.238 125.574 194.733 1.00 117.11 ? 196 PRO C CD  1 
ATOM 936  N N   . LYS A 1 197 ? 140.452 125.177 192.590 1.00 127.36 ? 197 LYS C N   1 
ATOM 937  C CA  . LYS A 1 197 ? 139.178 125.506 191.953 1.00 127.36 ? 197 LYS C CA  1 
ATOM 938  C C   . LYS A 1 197 ? 138.631 126.768 192.612 1.00 127.36 ? 197 LYS C C   1 
ATOM 939  O O   . LYS A 1 197 ? 138.238 126.752 193.782 1.00 127.36 ? 197 LYS C O   1 
ATOM 940  C CB  . LYS A 1 197 ? 138.196 124.347 192.072 1.00 127.36 ? 197 LYS C CB  1 
ATOM 941  C CG  . LYS A 1 197 ? 138.288 123.588 193.386 1.00 127.36 ? 197 LYS C CG  1 
ATOM 942  C CD  . LYS A 1 197 ? 137.032 122.776 193.639 1.00 127.36 ? 197 LYS C CD  1 
ATOM 943  C CE  . LYS A 1 197 ? 135.992 123.599 194.381 1.00 127.36 ? 197 LYS C CE  1 
ATOM 944  N NZ  . LYS A 1 197 ? 136.527 124.152 195.656 1.00 127.36 ? 197 LYS C NZ  1 
ATOM 945  N N   . ASN A 1 198 ? 138.607 127.867 191.862 1.00 129.54 ? 198 ASN C N   1 
ATOM 946  C CA  . ASN A 1 198 ? 138.094 129.135 192.363 1.00 129.54 ? 198 ASN C CA  1 
ATOM 947  C C   . ASN A 1 198 ? 137.811 130.052 191.179 1.00 129.54 ? 198 ASN C C   1 
ATOM 948  O O   . ASN A 1 198 ? 137.829 129.630 190.020 1.00 129.54 ? 198 ASN C O   1 
ATOM 949  C CB  . ASN A 1 198 ? 139.078 129.783 193.343 1.00 129.54 ? 198 ASN C CB  1 
ATOM 950  C CG  . ASN A 1 198 ? 138.532 129.858 194.754 1.00 129.54 ? 198 ASN C CG  1 
ATOM 951  O OD1 . ASN A 1 198 ? 137.322 129.795 194.967 1.00 129.54 ? 198 ASN C OD1 1 
ATOM 952  N ND2 . ASN A 1 198 ? 139.424 129.996 195.728 1.00 129.54 ? 198 ASN C ND2 1 
ATOM 953  N N   . LEU A 1 199 ? 137.549 131.323 191.483 1.00 120.98 ? 199 LEU C N   1 
ATOM 954  C CA  . LEU A 1 199 ? 137.356 132.336 190.451 1.00 120.98 ? 199 LEU C CA  1 
ATOM 955  C C   . LEU A 1 199 ? 138.693 132.693 189.817 1.00 120.98 ? 199 LEU C C   1 
ATOM 956  O O   . LEU A 1 199 ? 139.697 132.019 190.066 1.00 120.98 ? 199 LEU C O   1 
ATOM 957  C CB  . LEU A 1 199 ? 136.695 133.583 191.040 1.00 120.98 ? 199 LEU C CB  1 
ATOM 958  C CG  . LEU A 1 199 ? 137.397 134.205 192.251 1.00 120.98 ? 199 LEU C CG  1 
ATOM 959  C CD1 . LEU A 1 199 ? 138.207 135.435 191.845 1.00 120.98 ? 199 LEU C CD1 1 
ATOM 960  C CD2 . LEU A 1 199 ? 136.388 134.556 193.331 1.00 120.98 ? 199 LEU C CD2 1 
ATOM 961  N N   . THR A 1 200 ? 138.728 133.740 188.993 1.00 114.57 ? 200 THR C N   1 
ATOM 962  C CA  . THR A 1 200 ? 140.015 134.151 188.449 1.00 114.57 ? 200 THR C CA  1 
ATOM 963  C C   . THR A 1 200 ? 140.584 135.334 189.218 1.00 114.57 ? 200 THR C C   1 
ATOM 964  O O   . THR A 1 200 ? 141.538 135.174 189.980 1.00 114.57 ? 200 THR C O   1 
ATOM 965  C CB  . THR A 1 200 ? 139.882 134.529 186.974 1.00 114.57 ? 200 THR C CB  1 
ATOM 966  O OG1 . THR A 1 200 ? 139.065 135.701 186.852 1.00 114.57 ? 200 THR C OG1 1 
ATOM 967  C CG2 . THR A 1 200 ? 139.249 133.395 186.192 1.00 114.57 ? 200 THR C CG2 1 
ATOM 968  N N   . LEU A 1 201 ? 139.944 136.494 189.079 1.00 104.16 ? 201 LEU C N   1 
ATOM 969  C CA  . LEU A 1 201 ? 140.336 137.749 189.725 1.00 104.16 ? 201 LEU C CA  1 
ATOM 970  C C   . LEU A 1 201 ? 139.140 138.675 189.603 1.00 104.16 ? 201 LEU C C   1 
ATOM 971  O O   . LEU A 1 201 ? 138.832 139.119 188.493 1.00 104.16 ? 201 LEU C O   1 
ATOM 972  C CB  . LEU A 1 201 ? 141.567 138.359 189.031 1.00 104.16 ? 201 LEU C CB  1 
ATOM 973  C CG  . LEU A 1 201 ? 143.013 137.872 189.190 1.00 104.16 ? 201 LEU C CG  1 
ATOM 974  C CD1 . LEU A 1 201 ? 143.955 139.023 188.999 1.00 104.16 ? 201 LEU C CD1 1 
ATOM 975  C CD2 . LEU A 1 201 ? 143.250 137.350 190.587 1.00 104.16 ? 201 LEU C CD2 1 
ATOM 976  N N   . GLU A 1 202 ? 138.456 138.965 190.709 1.00 102.18 ? 202 GLU C N   1 
ATOM 977  C CA  . GLU A 1 202 ? 137.187 139.658 190.521 1.00 102.18 ? 202 GLU C CA  1 
ATOM 978  C C   . GLU A 1 202 ? 137.411 141.095 190.039 1.00 102.18 ? 202 GLU C C   1 
ATOM 979  O O   . GLU A 1 202 ? 137.195 141.375 188.856 1.00 102.18 ? 202 GLU C O   1 
ATOM 980  C CB  . GLU A 1 202 ? 136.340 139.557 191.802 1.00 102.18 ? 202 GLU C CB  1 
ATOM 981  C CG  . GLU A 1 202 ? 135.583 140.793 192.252 1.00 102.18 ? 202 GLU C CG  1 
ATOM 982  C CD  . GLU A 1 202 ? 134.942 140.605 193.604 1.00 102.18 ? 202 GLU C CD  1 
ATOM 983  O OE1 . GLU A 1 202 ? 135.355 141.283 194.566 1.00 102.18 ? 202 GLU C OE1 1 
ATOM 984  O OE2 . GLU A 1 202 ? 134.008 139.783 193.698 1.00 102.18 ? 202 GLU C OE2 1 
ATOM 985  N N   . ARG A 1 203 ? 137.848 142.014 190.905 1.00 89.68  ? 203 ARG C N   1 
ATOM 986  C CA  . ARG A 1 203 ? 138.417 143.269 190.429 1.00 89.68  ? 203 ARG C CA  1 
ATOM 987  C C   . ARG A 1 203 ? 139.460 143.833 191.387 1.00 89.68  ? 203 ARG C C   1 
ATOM 988  O O   . ARG A 1 203 ? 140.382 144.542 190.970 1.00 89.68  ? 203 ARG C O   1 
ATOM 989  C CB  . ARG A 1 203 ? 137.319 144.307 190.192 1.00 89.68  ? 203 ARG C CB  1 
ATOM 990  C CG  . ARG A 1 203 ? 137.831 145.570 189.524 1.00 89.68  ? 203 ARG C CG  1 
ATOM 991  C CD  . ARG A 1 203 ? 137.004 146.779 189.906 1.00 89.68  ? 203 ARG C CD  1 
ATOM 992  N NE  . ARG A 1 203 ? 137.520 148.015 189.326 1.00 89.68  ? 203 ARG C NE  1 
ATOM 993  C CZ  . ARG A 1 203 ? 137.427 148.351 188.046 1.00 89.68  ? 203 ARG C CZ  1 
ATOM 994  N NH1 . ARG A 1 203 ? 136.848 147.556 187.162 1.00 89.68  ? 203 ARG C NH1 1 
ATOM 995  N NH2 . ARG A 1 203 ? 137.925 149.516 187.644 1.00 89.68  ? 203 ARG C NH2 1 
ATOM 996  N N   . HIS A 1 204 ? 139.326 143.507 192.676 1.00 89.81  ? 204 HIS C N   1 
ATOM 997  C CA  . HIS A 1 204 ? 139.918 144.345 193.714 1.00 89.81  ? 204 HIS C CA  1 
ATOM 998  C C   . HIS A 1 204 ? 141.423 144.181 193.828 1.00 89.81  ? 204 HIS C C   1 
ATOM 999  O O   . HIS A 1 204 ? 142.104 145.132 194.226 1.00 89.81  ? 204 HIS C O   1 
ATOM 1000 C CB  . HIS A 1 204 ? 139.292 144.051 195.082 1.00 89.81  ? 204 HIS C CB  1 
ATOM 1001 C CG  . HIS A 1 204 ? 139.036 142.599 195.343 1.00 89.81  ? 204 HIS C CG  1 
ATOM 1002 N ND1 . HIS A 1 204 ? 138.170 141.837 194.586 1.00 89.81  ? 204 HIS C ND1 1 
ATOM 1003 C CD2 . HIS A 1 204 ? 139.550 141.765 196.277 1.00 89.81  ? 204 HIS C CD2 1 
ATOM 1004 C CE1 . HIS A 1 204 ? 138.158 140.600 195.048 1.00 89.81  ? 204 HIS C CE1 1 
ATOM 1005 N NE2 . HIS A 1 204 ? 138.983 140.530 196.076 1.00 89.81  ? 204 HIS C NE2 1 
ATOM 1006 N N   . GLN A 1 205 ? 141.954 143.004 193.510 1.00 84.95  ? 205 GLN C N   1 
ATOM 1007 C CA  . GLN A 1 205 ? 143.389 142.760 193.585 1.00 84.95  ? 205 GLN C CA  1 
ATOM 1008 C C   . GLN A 1 205 ? 144.155 143.661 192.621 1.00 84.95  ? 205 GLN C C   1 
ATOM 1009 O O   . GLN A 1 205 ? 145.327 143.974 192.851 1.00 84.95  ? 205 GLN C O   1 
ATOM 1010 C CB  . GLN A 1 205 ? 143.660 141.279 193.319 1.00 84.95  ? 205 GLN C CB  1 
ATOM 1011 C CG  . GLN A 1 205 ? 143.366 140.409 194.522 1.00 84.95  ? 205 GLN C CG  1 
ATOM 1012 C CD  . GLN A 1 205 ? 142.798 139.063 194.148 1.00 84.95  ? 205 GLN C CD  1 
ATOM 1013 O OE1 . GLN A 1 205 ? 143.499 138.055 194.168 1.00 84.95  ? 205 GLN C OE1 1 
ATOM 1014 N NE2 . GLN A 1 205 ? 141.508 139.033 193.836 1.00 84.95  ? 205 GLN C NE2 1 
ATOM 1015 N N   . LEU A 1 206 ? 143.506 144.072 191.530 1.00 76.00  ? 206 LEU C N   1 
ATOM 1016 C CA  . LEU A 1 206 ? 144.091 145.053 190.626 1.00 76.00  ? 206 LEU C CA  1 
ATOM 1017 C C   . LEU A 1 206 ? 143.997 146.471 191.168 1.00 76.00  ? 206 LEU C C   1 
ATOM 1018 O O   . LEU A 1 206 ? 144.727 147.348 190.695 1.00 76.00  ? 206 LEU C O   1 
ATOM 1019 C CB  . LEU A 1 206 ? 143.422 144.980 189.249 1.00 76.00  ? 206 LEU C CB  1 
ATOM 1020 C CG  . LEU A 1 206 ? 143.837 143.863 188.282 1.00 76.00  ? 206 LEU C CG  1 
ATOM 1021 C CD1 . LEU A 1 206 ? 143.741 142.486 188.903 1.00 76.00  ? 206 LEU C CD1 1 
ATOM 1022 C CD2 . LEU A 1 206 ? 143.029 143.912 187.000 1.00 76.00  ? 206 LEU C CD2 1 
ATOM 1023 N N   . THR A 1 207 ? 143.123 146.715 192.141 1.00 81.66  ? 207 THR C N   1 
ATOM 1024 C CA  . THR A 1 207 ? 143.047 147.996 192.826 1.00 81.66  ? 207 THR C CA  1 
ATOM 1025 C C   . THR A 1 207 ? 143.758 147.953 194.171 1.00 81.66  ? 207 THR C C   1 
ATOM 1026 O O   . THR A 1 207 ? 144.281 148.980 194.620 1.00 81.66  ? 207 THR C O   1 
ATOM 1027 C CB  . THR A 1 207 ? 141.574 148.406 192.999 1.00 81.66  ? 207 THR C CB  1 
ATOM 1028 O OG1 . THR A 1 207 ? 141.037 148.795 191.729 1.00 81.66  ? 207 THR C OG1 1 
ATOM 1029 C CG2 . THR A 1 207 ? 141.419 149.568 193.972 1.00 81.66  ? 207 THR C CG2 1 
ATOM 1030 N N   . GLU A 1 208 ? 143.834 146.776 194.797 1.00 86.90  ? 208 GLU C N   1 
ATOM 1031 C CA  . GLU A 1 208 ? 144.560 146.638 196.054 1.00 86.90  ? 208 GLU C CA  1 
ATOM 1032 C C   . GLU A 1 208 ? 146.026 147.013 195.882 1.00 86.90  ? 208 GLU C C   1 
ATOM 1033 O O   . GLU A 1 208 ? 146.600 147.718 196.720 1.00 86.90  ? 208 GLU C O   1 
ATOM 1034 C CB  . GLU A 1 208 ? 144.434 145.205 196.575 1.00 86.90  ? 208 GLU C CB  1 
ATOM 1035 C CG  . GLU A 1 208 ? 143.334 144.999 197.601 1.00 86.90  ? 208 GLU C CG  1 
ATOM 1036 C CD  . GLU A 1 208 ? 143.808 145.233 199.020 1.00 86.90  ? 208 GLU C CD  1 
ATOM 1037 O OE1 . GLU A 1 208 ? 145.007 145.530 199.206 1.00 86.90  ? 208 GLU C OE1 1 
ATOM 1038 O OE2 . GLU A 1 208 ? 142.984 145.114 199.952 1.00 86.90  ? 208 GLU C OE2 1 
ATOM 1039 N N   . VAL A 1 209 ? 146.650 146.551 194.799 1.00 64.00  ? 209 VAL C N   1 
ATOM 1040 C CA  . VAL A 1 209 ? 148.059 146.831 194.549 1.00 64.00  ? 209 VAL C CA  1 
ATOM 1041 C C   . VAL A 1 209 ? 148.204 148.016 193.598 1.00 64.00  ? 209 VAL C C   1 
ATOM 1042 O O   . VAL A 1 209 ? 149.094 148.853 193.776 1.00 64.00  ? 209 VAL C O   1 
ATOM 1043 C CB  . VAL A 1 209 ? 148.787 145.573 194.036 1.00 64.00  ? 209 VAL C CB  1 
ATOM 1044 C CG1 . VAL A 1 209 ? 148.435 144.385 194.910 1.00 64.00  ? 209 VAL C CG1 1 
ATOM 1045 C CG2 . VAL A 1 209 ? 148.418 145.267 192.604 1.00 64.00  ? 209 VAL C CG2 1 
ATOM 1046 N N   . GLY A 1 210 ? 147.333 148.113 192.595 1.00 63.22  ? 210 GLY C N   1 
ATOM 1047 C CA  . GLY A 1 210 ? 147.330 149.293 191.752 1.00 63.22  ? 210 GLY C CA  1 
ATOM 1048 C C   . GLY A 1 210 ? 147.518 149.074 190.263 1.00 63.22  ? 210 GLY C C   1 
ATOM 1049 O O   . GLY A 1 210 ? 147.856 150.017 189.542 1.00 63.22  ? 210 GLY C O   1 
ATOM 1050 N N   . LEU A 1 211 ? 147.312 147.850 189.783 1.00 59.91  ? 211 LEU C N   1 
ATOM 1051 C CA  . LEU A 1 211 ? 147.414 147.565 188.357 1.00 59.91  ? 211 LEU C CA  1 
ATOM 1052 C C   . LEU A 1 211 ? 146.285 148.178 187.536 1.00 59.91  ? 211 LEU C C   1 
ATOM 1053 O O   . LEU A 1 211 ? 146.435 148.321 186.319 1.00 59.91  ? 211 LEU C O   1 
ATOM 1054 C CB  . LEU A 1 211 ? 147.460 146.053 188.108 1.00 59.91  ? 211 LEU C CB  1 
ATOM 1055 C CG  . LEU A 1 211 ? 148.354 145.148 188.954 1.00 59.91  ? 211 LEU C CG  1 
ATOM 1056 C CD1 . LEU A 1 211 ? 148.666 143.892 188.170 1.00 59.91  ? 211 LEU C CD1 1 
ATOM 1057 C CD2 . LEU A 1 211 ? 149.655 145.850 189.305 1.00 59.91  ? 211 LEU C CD2 1 
ATOM 1058 N N   . LEU A 1 212 ? 145.170 148.546 188.161 1.00 67.78  ? 212 LEU C N   1 
ATOM 1059 C CA  . LEU A 1 212 ? 144.079 149.194 187.447 1.00 67.78  ? 212 LEU C CA  1 
ATOM 1060 C C   . LEU A 1 212 ? 143.668 150.454 188.189 1.00 67.78  ? 212 LEU C C   1 
ATOM 1061 O O   . LEU A 1 212 ? 143.988 150.641 189.365 1.00 67.78  ? 212 LEU C O   1 
ATOM 1062 C CB  . LEU A 1 212 ? 142.863 148.278 187.276 1.00 67.78  ? 212 LEU C CB  1 
ATOM 1063 C CG  . LEU A 1 212 ? 142.673 147.669 185.888 1.00 67.78  ? 212 LEU C CG  1 
ATOM 1064 C CD1 . LEU A 1 212 ? 141.437 146.789 185.858 1.00 67.78  ? 212 LEU C CD1 1 
ATOM 1065 C CD2 . LEU A 1 212 ? 142.580 148.764 184.840 1.00 67.78  ? 212 LEU C CD2 1 
ATOM 1066 N N   . ASP A 1 213 ? 142.958 151.324 187.471 1.00 72.66  ? 213 ASP C N   1 
ATOM 1067 C CA  . ASP A 1 213 ? 142.457 152.591 187.997 1.00 72.66  ? 213 ASP C CA  1 
ATOM 1068 C C   . ASP A 1 213 ? 143.578 153.485 188.513 1.00 72.66  ? 213 ASP C C   1 
ATOM 1069 O O   . ASP A 1 213 ? 143.334 154.402 189.303 1.00 72.66  ? 213 ASP C O   1 
ATOM 1070 C CB  . ASP A 1 213 ? 141.410 152.361 189.094 1.00 72.66  ? 213 ASP C CB  1 
ATOM 1071 C CG  . ASP A 1 213 ? 140.394 151.300 188.715 1.00 72.66  ? 213 ASP C CG  1 
ATOM 1072 O OD1 . ASP A 1 213 ? 139.568 151.560 187.815 1.00 72.66  ? 213 ASP C OD1 1 
ATOM 1073 O OD2 . ASP A 1 213 ? 140.421 150.206 189.317 1.00 72.66  ? 213 ASP C OD2 1 
ATOM 1074 N N   . ASN A 1 214 ? 144.810 153.231 188.076 1.00 60.76  ? 214 ASN C N   1 
ATOM 1075 C CA  . ASN A 1 214 ? 145.946 154.050 188.458 1.00 60.76  ? 214 ASN C CA  1 
ATOM 1076 C C   . ASN A 1 214 ? 146.334 154.925 187.280 1.00 60.76  ? 214 ASN C C   1 
ATOM 1077 O O   . ASN A 1 214 ? 146.855 154.405 186.282 1.00 60.76  ? 214 ASN C O   1 
ATOM 1078 C CB  . ASN A 1 214 ? 147.120 153.176 188.881 1.00 60.76  ? 214 ASN C CB  1 
ATOM 1079 C CG  . ASN A 1 214 ? 148.255 153.974 189.487 1.00 60.76  ? 214 ASN C CG  1 
ATOM 1080 O OD1 . ASN A 1 214 ? 148.156 155.188 189.659 1.00 60.76  ? 214 ASN C OD1 1 
ATOM 1081 N ND2 . ASN A 1 214 ? 149.344 153.291 189.819 1.00 60.76  ? 214 ASN C ND2 1 
ATOM 1082 N N   . PRO A 1 215 ? 146.103 156.239 187.339 1.00 60.96  ? 215 PRO C N   1 
ATOM 1083 C CA  . PRO A 1 215 ? 146.407 157.098 186.186 1.00 60.96  ? 215 PRO C CA  1 
ATOM 1084 C C   . PRO A 1 215 ? 147.890 157.273 185.913 1.00 60.96  ? 215 PRO C C   1 
ATOM 1085 O O   . PRO A 1 215 ? 148.241 157.944 184.936 1.00 60.96  ? 215 PRO C O   1 
ATOM 1086 C CB  . PRO A 1 215 ? 145.761 158.438 186.572 1.00 60.96  ? 215 PRO C CB  1 
ATOM 1087 C CG  . PRO A 1 215 ? 145.695 158.408 188.061 1.00 60.96  ? 215 PRO C CG  1 
ATOM 1088 C CD  . PRO A 1 215 ? 145.441 156.979 188.426 1.00 60.96  ? 215 PRO C CD  1 
ATOM 1089 N N   . GLU A 1 216 ? 148.778 156.697 186.730 1.00 58.98  ? 216 GLU C N   1 
ATOM 1090 C CA  . GLU A 1 216 ? 150.204 156.925 186.536 1.00 58.98  ? 216 GLU C CA  1 
ATOM 1091 C C   . GLU A 1 216 ? 151.002 155.626 186.457 1.00 58.98  ? 216 GLU C C   1 
ATOM 1092 O O   . GLU A 1 216 ? 152.234 155.661 186.563 1.00 58.98  ? 216 GLU C O   1 
ATOM 1093 C CB  . GLU A 1 216 ? 150.765 157.808 187.655 1.00 58.98  ? 216 GLU C CB  1 
ATOM 1094 C CG  . GLU A 1 216 ? 150.517 159.297 187.456 1.00 58.98  ? 216 GLU C CG  1 
ATOM 1095 C CD  . GLU A 1 216 ? 150.811 159.763 186.042 1.00 58.98  ? 216 GLU C CD  1 
ATOM 1096 O OE1 . GLU A 1 216 ? 151.931 159.515 185.548 1.00 58.98  ? 216 GLU C OE1 1 
ATOM 1097 O OE2 . GLU A 1 216 ? 149.920 160.382 185.423 1.00 58.98  ? 216 GLU C OE2 1 
ATOM 1098 N N   . LEU A 1 217 ? 150.340 154.483 186.277 1.00 52.78  ? 217 LEU C N   1 
ATOM 1099 C CA  . LEU A 1 217 ? 151.044 153.224 186.066 1.00 52.78  ? 217 LEU C CA  1 
ATOM 1100 C C   . LEU A 1 217 ? 151.741 153.239 184.715 1.00 52.78  ? 217 LEU C C   1 
ATOM 1101 O O   . LEU A 1 217 ? 151.083 153.378 183.679 1.00 52.78  ? 217 LEU C O   1 
ATOM 1102 C CB  . LEU A 1 217 ? 150.079 152.041 186.144 1.00 52.78  ? 217 LEU C CB  1 
ATOM 1103 C CG  . LEU A 1 217 ? 150.718 150.676 186.390 1.00 52.78  ? 217 LEU C CG  1 
ATOM 1104 C CD1 . LEU A 1 217 ? 151.235 150.584 187.810 1.00 52.78  ? 217 LEU C CD1 1 
ATOM 1105 C CD2 . LEU A 1 217 ? 149.731 149.563 186.103 1.00 52.78  ? 217 LEU C CD2 1 
ATOM 1106 N N   . ARG A 1 218 ? 153.065 153.102 184.703 1.00 46.82  ? 218 ARG C N   1 
ATOM 1107 C CA  . ARG A 1 218 ? 153.790 153.201 183.444 1.00 46.82  ? 218 ARG C CA  1 
ATOM 1108 C C   . ARG A 1 218 ? 154.661 151.989 183.146 1.00 46.82  ? 218 ARG C C   1 
ATOM 1109 O O   . ARG A 1 218 ? 154.869 151.670 181.971 1.00 46.82  ? 218 ARG C O   1 
ATOM 1110 C CB  . ARG A 1 218 ? 154.639 154.473 183.431 1.00 46.82  ? 218 ARG C CB  1 
ATOM 1111 C CG  . ARG A 1 218 ? 153.799 155.728 183.560 1.00 46.82  ? 218 ARG C CG  1 
ATOM 1112 C CD  . ARG A 1 218 ? 154.302 156.851 182.680 1.00 46.82  ? 218 ARG C CD  1 
ATOM 1113 N NE  . ARG A 1 218 ? 154.025 158.155 183.268 1.00 46.82  ? 218 ARG C NE  1 
ATOM 1114 C CZ  . ARG A 1 218 ? 154.568 159.292 182.858 1.00 46.82  ? 218 ARG C CZ  1 
ATOM 1115 N NH1 . ARG A 1 218 ? 155.419 159.326 181.847 1.00 46.82  ? 218 ARG C NH1 1 
ATOM 1116 N NH2 . ARG A 1 218 ? 154.248 160.424 183.478 1.00 46.82  ? 218 ARG C NH2 1 
ATOM 1117 N N   . VAL A 1 219 ? 155.177 151.303 184.163 1.00 38.68  ? 219 VAL C N   1 
ATOM 1118 C CA  . VAL A 1 219 ? 156.002 150.116 183.958 1.00 38.68  ? 219 VAL C CA  1 
ATOM 1119 C C   . VAL A 1 219 ? 155.539 149.018 184.903 1.00 38.68  ? 219 VAL C C   1 
ATOM 1120 O O   . VAL A 1 219 ? 155.293 149.274 186.086 1.00 38.68  ? 219 VAL C O   1 
ATOM 1121 C CB  . VAL A 1 219 ? 157.501 150.399 184.177 1.00 38.68  ? 219 VAL C CB  1 
ATOM 1122 C CG1 . VAL A 1 219 ? 158.318 149.174 183.817 1.00 38.68  ? 219 VAL C CG1 1 
ATOM 1123 C CG2 . VAL A 1 219 ? 157.951 151.596 183.361 1.00 38.68  ? 219 VAL C CG2 1 
ATOM 1124 N N   . VAL A 1 220 ? 155.428 147.798 184.386 1.00 28.77  ? 220 VAL C N   1 
ATOM 1125 C CA  . VAL A 1 220 ? 155.166 146.621 185.199 1.00 28.77  ? 220 VAL C CA  1 
ATOM 1126 C C   . VAL A 1 220 ? 156.199 145.559 184.825 1.00 28.77  ? 220 VAL C C   1 
ATOM 1127 O O   . VAL A 1 220 ? 156.715 145.528 183.708 1.00 28.77  ? 220 VAL C O   1 
ATOM 1128 C CB  . VAL A 1 220 ? 153.725 146.097 185.025 1.00 28.77  ? 220 VAL C CB  1 
ATOM 1129 C CG1 . VAL A 1 220 ? 153.495 145.615 183.608 1.00 28.77  ? 220 VAL C CG1 1 
ATOM 1130 C CG2 . VAL A 1 220 ? 153.406 145.009 186.038 1.00 28.77  ? 220 VAL C CG2 1 
ATOM 1131 N N   . LEU A 1 221 ? 156.507 144.692 185.785 1.00 36.02  ? 221 LEU C N   1 
ATOM 1132 C CA  . LEU A 1 221 ? 157.590 143.726 185.634 1.00 36.02  ? 221 LEU C CA  1 
ATOM 1133 C C   . LEU A 1 221 ? 157.082 142.324 185.959 1.00 36.02  ? 221 LEU C C   1 
ATOM 1134 O O   . LEU A 1 221 ? 157.664 141.600 186.766 1.00 36.02  ? 221 LEU C O   1 
ATOM 1135 C CB  . LEU A 1 221 ? 158.782 144.103 186.514 1.00 36.02  ? 221 LEU C CB  1 
ATOM 1136 C CG  . LEU A 1 221 ? 159.703 145.199 185.980 1.00 36.02  ? 221 LEU C CG  1 
ATOM 1137 C CD1 . LEU A 1 221 ? 160.717 145.593 187.033 1.00 36.02  ? 221 LEU C CD1 1 
ATOM 1138 C CD2 . LEU A 1 221 ? 160.397 144.747 184.714 1.00 36.02  ? 221 LEU C CD2 1 
ATOM 1139 N N   . VAL A 1 222 ? 155.966 141.940 185.341 1.00 40.70  ? 222 VAL C N   1 
ATOM 1140 C CA  . VAL A 1 222 ? 155.298 140.668 185.604 1.00 40.70  ? 222 VAL C CA  1 
ATOM 1141 C C   . VAL A 1 222 ? 156.253 139.488 185.485 1.00 40.70  ? 222 VAL C C   1 
ATOM 1142 O O   . VAL A 1 222 ? 156.956 139.339 184.479 1.00 40.70  ? 222 VAL C O   1 
ATOM 1143 C CB  . VAL A 1 222 ? 154.103 140.487 184.653 1.00 40.70  ? 222 VAL C CB  1 
ATOM 1144 C CG1 . VAL A 1 222 ? 153.513 139.099 184.797 1.00 40.70  ? 222 VAL C CG1 1 
ATOM 1145 C CG2 . VAL A 1 222 ? 153.053 141.543 184.925 1.00 40.70  ? 222 VAL C CG2 1 
ATOM 1146 N N   . PHE A 1 223 ? 156.279 138.642 186.513 1.00 48.27  ? 223 PHE C N   1 
ATOM 1147 C CA  . PHE A 1 223 ? 157.024 137.394 186.517 1.00 48.27  ? 223 PHE C CA  1 
ATOM 1148 C C   . PHE A 1 223 ? 156.059 136.240 186.755 1.00 48.27  ? 223 PHE C C   1 
ATOM 1149 O O   . PHE A 1 223 ? 154.968 136.422 187.302 1.00 48.27  ? 223 PHE C O   1 
ATOM 1150 C CB  . PHE A 1 223 ? 158.108 137.382 187.602 1.00 48.27  ? 223 PHE C CB  1 
ATOM 1151 C CG  . PHE A 1 223 ? 159.198 138.389 187.389 1.00 48.27  ? 223 PHE C CG  1 
ATOM 1152 C CD1 . PHE A 1 223 ? 160.114 138.236 186.368 1.00 48.27  ? 223 PHE C CD1 1 
ATOM 1153 C CD2 . PHE A 1 223 ? 159.306 139.490 188.218 1.00 48.27  ? 223 PHE C CD2 1 
ATOM 1154 C CE1 . PHE A 1 223 ? 161.117 139.165 186.176 1.00 48.27  ? 223 PHE C CE1 1 
ATOM 1155 C CE2 . PHE A 1 223 ? 160.306 140.421 188.031 1.00 48.27  ? 223 PHE C CE2 1 
ATOM 1156 C CZ  . PHE A 1 223 ? 161.212 140.258 187.009 1.00 48.27  ? 223 PHE C CZ  1 
ATOM 1157 N N   . GLY A 1 224 ? 156.470 135.045 186.349 1.00 60.47  ? 224 GLY C N   1 
ATOM 1158 C CA  . GLY A 1 224 ? 155.637 133.871 186.526 1.00 60.47  ? 224 GLY C CA  1 
ATOM 1159 C C   . GLY A 1 224 ? 156.477 132.664 186.860 1.00 60.47  ? 224 GLY C C   1 
ATOM 1160 O O   . GLY A 1 224 ? 157.633 132.558 186.440 1.00 60.47  ? 224 GLY C O   1 
ATOM 1161 N N   . TYR A 1 225 ? 155.892 131.743 187.625 1.00 74.09  ? 225 TYR C N   1 
ATOM 1162 C CA  . TYR A 1 225 ? 156.627 130.564 188.066 1.00 74.09  ? 225 TYR C CA  1 
ATOM 1163 C C   . TYR A 1 225 ? 155.758 129.313 188.076 1.00 74.09  ? 225 TYR C C   1 
ATOM 1164 O O   . TYR A 1 225 ? 154.535 129.400 188.225 1.00 74.09  ? 225 TYR C O   1 
ATOM 1165 C CB  . TYR A 1 225 ? 157.225 130.800 189.454 1.00 74.09  ? 225 TYR C CB  1 
ATOM 1166 C CG  . TYR A 1 225 ? 156.224 131.203 190.513 1.00 74.09  ? 225 TYR C CG  1 
ATOM 1167 C CD1 . TYR A 1 225 ? 155.764 132.510 190.601 1.00 74.09  ? 225 TYR C CD1 1 
ATOM 1168 C CD2 . TYR A 1 225 ? 155.744 130.280 191.430 1.00 74.09  ? 225 TYR C CD2 1 
ATOM 1169 C CE1 . TYR A 1 225 ? 154.853 132.884 191.569 1.00 74.09  ? 225 TYR C CE1 1 
ATOM 1170 C CE2 . TYR A 1 225 ? 154.834 130.646 192.402 1.00 74.09  ? 225 TYR C CE2 1 
ATOM 1171 C CZ  . TYR A 1 225 ? 154.392 131.949 192.467 1.00 74.09  ? 225 TYR C CZ  1 
ATOM 1172 O OH  . TYR A 1 225 ? 153.485 132.317 193.433 1.00 74.09  ? 225 TYR C OH  1 
ATOM 1173 N N   . ASN A 1 226 ? 156.394 128.147 187.928 1.00 84.05  ? 226 ASN C N   1 
ATOM 1174 C CA  . ASN A 1 226 ? 155.721 126.852 187.934 1.00 84.05  ? 226 ASN C CA  1 
ATOM 1175 C C   . ASN A 1 226 ? 154.574 126.806 186.932 1.00 84.05  ? 226 ASN C C   1 
ATOM 1176 O O   . ASN A 1 226 ? 153.466 126.373 187.264 1.00 84.05  ? 226 ASN C O   1 
ATOM 1177 C CB  . ASN A 1 226 ? 155.214 126.518 189.338 1.00 84.05  ? 226 ASN C CB  1 
ATOM 1178 C CG  . ASN A 1 226 ? 156.336 126.196 190.303 1.00 84.05  ? 226 ASN C CG  1 
ATOM 1179 O OD1 . ASN A 1 226 ? 157.419 125.777 189.895 1.00 84.05  ? 226 ASN C OD1 1 
ATOM 1180 N ND2 . ASN A 1 226 ? 156.084 126.392 191.592 1.00 84.05  ? 226 ASN C ND2 1 
ATOM 1181 N N   . CYS A 1 227 ? 154.833 127.247 185.700 1.00 102.58 ? 227 CYS C N   1 
ATOM 1182 C CA  . CYS A 1 227 ? 153.780 127.298 184.691 1.00 102.58 ? 227 CYS C CA  1 
ATOM 1183 C C   . CYS A 1 227 ? 153.701 125.993 183.906 1.00 102.58 ? 227 CYS C C   1 
ATOM 1184 O O   . CYS A 1 227 ? 152.962 125.896 182.920 1.00 102.58 ? 227 CYS C O   1 
ATOM 1185 C CB  . CYS A 1 227 ? 154.017 128.480 183.751 1.00 102.58 ? 227 CYS C CB  1 
ATOM 1186 S SG  . CYS A 1 227 ? 154.644 129.963 184.571 1.00 102.58 ? 227 CYS C SG  1 
ATOM 1187 N N   . CYS A 1 228 ? 154.466 124.983 184.323 1.00 120.20 ? 228 CYS C N   1 
ATOM 1188 C CA  . CYS A 1 228 ? 154.543 123.711 183.611 1.00 120.20 ? 228 CYS C CA  1 
ATOM 1189 C C   . CYS A 1 228 ? 153.183 123.034 183.476 1.00 120.20 ? 228 CYS C C   1 
ATOM 1190 O O   . CYS A 1 228 ? 152.823 122.570 182.389 1.00 120.20 ? 228 CYS C O   1 
ATOM 1191 C CB  . CYS A 1 228 ? 155.524 122.772 184.317 1.00 120.20 ? 228 CYS C CB  1 
ATOM 1192 S SG  . CYS A 1 228 ? 157.245 122.969 183.805 1.00 120.20 ? 228 CYS C SG  1 
ATOM 1193 N N   . LYS A 1 229 ? 152.426 122.966 184.570 1.00 120.73 ? 229 LYS C N   1 
ATOM 1194 C CA  . LYS A 1 229 ? 151.125 122.309 184.543 1.00 120.73 ? 229 LYS C CA  1 
ATOM 1195 C C   . LYS A 1 229 ? 150.157 123.069 183.644 1.00 120.73 ? 229 LYS C C   1 
ATOM 1196 O O   . LYS A 1 229 ? 150.198 124.300 183.550 1.00 120.73 ? 229 LYS C O   1 
ATOM 1197 C CB  . LYS A 1 229 ? 150.557 122.200 185.961 1.00 120.73 ? 229 LYS C CB  1 
ATOM 1198 C CG  . LYS A 1 229 ? 149.190 121.533 186.046 1.00 120.73 ? 229 LYS C CG  1 
ATOM 1199 C CD  . LYS A 1 229 ? 149.272 120.047 185.738 1.00 120.73 ? 229 LYS C CD  1 
ATOM 1200 C CE  . LYS A 1 229 ? 150.153 119.325 186.741 1.00 120.73 ? 229 LYS C CE  1 
ATOM 1201 N NZ  . LYS A 1 229 ? 149.740 119.617 188.141 1.00 120.73 ? 229 LYS C NZ  1 
ATOM 1202 N N   . VAL A 1 230 ? 149.285 122.320 182.968 1.00 123.49 ? 230 VAL C N   1 
ATOM 1203 C CA  . VAL A 1 230 ? 148.241 122.906 182.135 1.00 123.49 ? 230 VAL C CA  1 
ATOM 1204 C C   . VAL A 1 230 ? 147.320 123.728 183.026 1.00 123.49 ? 230 VAL C C   1 
ATOM 1205 O O   . VAL A 1 230 ? 147.223 123.483 184.234 1.00 123.49 ? 230 VAL C O   1 
ATOM 1206 C CB  . VAL A 1 230 ? 147.462 121.826 181.358 1.00 123.49 ? 230 VAL C CB  1 
ATOM 1207 C CG1 . VAL A 1 230 ? 146.331 121.257 182.204 1.00 123.49 ? 230 VAL C CG1 1 
ATOM 1208 C CG2 . VAL A 1 230 ? 146.925 122.394 180.053 1.00 123.49 ? 230 VAL C CG2 1 
ATOM 1209 N N   . GLY A 1 231 ? 146.650 124.712 182.445 1.00 115.19 ? 231 GLY C N   1 
ATOM 1210 C CA  . GLY A 1 231 ? 145.909 125.671 183.260 1.00 115.19 ? 231 GLY C CA  1 
ATOM 1211 C C   . GLY A 1 231 ? 146.806 126.728 183.860 1.00 115.19 ? 231 GLY C C   1 
ATOM 1212 O O   . GLY A 1 231 ? 146.541 127.924 183.709 1.00 115.19 ? 231 GLY C O   1 
ATOM 1213 N N   . ALA A 1 232 ? 147.874 126.312 184.546 1.00 114.07 ? 232 ALA C N   1 
ATOM 1214 C CA  . ALA A 1 232 ? 148.884 127.255 185.011 1.00 114.07 ? 232 ALA C CA  1 
ATOM 1215 C C   . ALA A 1 232 ? 149.595 127.936 183.851 1.00 114.07 ? 232 ALA C C   1 
ATOM 1216 O O   . ALA A 1 232 ? 149.876 129.138 183.920 1.00 114.07 ? 232 ALA C O   1 
ATOM 1217 C CB  . ALA A 1 232 ? 149.901 126.545 185.906 1.00 114.07 ? 232 ALA C CB  1 
ATOM 1218 N N   . SER A 1 233 ? 149.899 127.188 182.788 1.00 112.06 ? 233 SER C N   1 
ATOM 1219 C CA  . SER A 1 233 ? 150.437 127.804 181.581 1.00 112.06 ? 233 SER C CA  1 
ATOM 1220 C C   . SER A 1 233 ? 149.441 128.794 180.995 1.00 112.06 ? 233 SER C C   1 
ATOM 1221 O O   . SER A 1 233 ? 149.816 129.881 180.542 1.00 112.06 ? 233 SER C O   1 
ATOM 1222 C CB  . SER A 1 233 ? 150.797 126.726 180.557 1.00 112.06 ? 233 SER C CB  1 
ATOM 1223 O OG  . SER A 1 233 ? 149.747 125.785 180.420 1.00 112.06 ? 233 SER C OG  1 
ATOM 1224 N N   . ASN A 1 234 ? 148.162 128.434 181.000 1.00 99.53  ? 234 ASN C N   1 
ATOM 1225 C CA  . ASN A 1 234 ? 147.111 129.354 180.592 1.00 99.53  ? 234 ASN C CA  1 
ATOM 1226 C C   . ASN A 1 234 ? 146.737 130.335 181.681 1.00 99.53  ? 234 ASN C C   1 
ATOM 1227 O O   . ASN A 1 234 ? 146.033 131.303 181.374 1.00 99.53  ? 234 ASN C O   1 
ATOM 1228 C CB  . ASN A 1 234 ? 145.874 128.574 180.146 1.00 99.53  ? 234 ASN C CB  1 
ATOM 1229 C CG  . ASN A 1 234 ? 146.117 127.765 178.891 1.00 99.53  ? 234 ASN C CG  1 
ATOM 1230 O OD1 . ASN A 1 234 ? 147.059 128.028 178.144 1.00 99.53  ? 234 ASN C OD1 1 
ATOM 1231 N ND2 . ASN A 1 234 ? 145.265 126.777 178.650 1.00 99.53  ? 234 ASN C ND2 1 
ATOM 1232 N N   . TYR A 1 235 ? 147.154 130.135 182.933 1.00 91.15  ? 235 TYR C N   1 
ATOM 1233 C CA  . TYR A 1 235 ? 146.878 131.130 183.963 1.00 91.15  ? 235 TYR C CA  1 
ATOM 1234 C C   . TYR A 1 235 ? 147.580 132.439 183.631 1.00 91.15  ? 235 TYR C C   1 
ATOM 1235 O O   . TYR A 1 235 ? 146.977 133.515 183.717 1.00 91.15  ? 235 TYR C O   1 
ATOM 1236 C CB  . TYR A 1 235 ? 147.304 130.597 185.339 1.00 91.15  ? 235 TYR C CB  1 
ATOM 1237 C CG  . TYR A 1 235 ? 146.916 131.452 186.539 1.00 91.15  ? 235 TYR C CG  1 
ATOM 1238 C CD1 . TYR A 1 235 ? 147.310 132.781 186.650 1.00 91.15  ? 235 TYR C CD1 1 
ATOM 1239 C CD2 . TYR A 1 235 ? 146.142 130.919 187.560 1.00 91.15  ? 235 TYR C CD2 1 
ATOM 1240 C CE1 . TYR A 1 235 ? 146.948 133.546 187.739 1.00 91.15  ? 235 TYR C CE1 1 
ATOM 1241 C CE2 . TYR A 1 235 ? 145.778 131.678 188.654 1.00 91.15  ? 235 TYR C CE2 1 
ATOM 1242 C CZ  . TYR A 1 235 ? 146.183 132.989 188.738 1.00 91.15  ? 235 TYR C CZ  1 
ATOM 1243 O OH  . TYR A 1 235 ? 145.821 133.748 189.827 1.00 91.15  ? 235 TYR C OH  1 
ATOM 1244 N N   . LEU A 1 236 ? 148.852 132.362 183.231 1.00 77.88  ? 236 LEU C N   1 
ATOM 1245 C CA  . LEU A 1 236 ? 149.565 133.561 182.807 1.00 77.88  ? 236 LEU C CA  1 
ATOM 1246 C C   . LEU A 1 236 ? 148.898 134.194 181.595 1.00 77.88  ? 236 LEU C C   1 
ATOM 1247 O O   . LEU A 1 236 ? 148.945 135.418 181.426 1.00 77.88  ? 236 LEU C O   1 
ATOM 1248 C CB  . LEU A 1 236 ? 151.025 133.226 182.501 1.00 77.88  ? 236 LEU C CB  1 
ATOM 1249 C CG  . LEU A 1 236 ? 151.949 134.426 182.298 1.00 77.88  ? 236 LEU C CG  1 
ATOM 1250 C CD1 . LEU A 1 236 ? 152.037 135.240 183.573 1.00 77.88  ? 236 LEU C CD1 1 
ATOM 1251 C CD2 . LEU A 1 236 ? 153.328 133.982 181.846 1.00 77.88  ? 236 LEU C CD2 1 
ATOM 1252 N N   . GLN A 1 237 ? 148.271 133.379 180.744 1.00 83.72  ? 237 GLN C N   1 
ATOM 1253 C CA  . GLN A 1 237 ? 147.495 133.911 179.629 1.00 83.72  ? 237 GLN C CA  1 
ATOM 1254 C C   . GLN A 1 237 ? 146.335 134.765 180.129 1.00 83.72  ? 237 GLN C C   1 
ATOM 1255 O O   . GLN A 1 237 ? 146.075 135.851 179.599 1.00 83.72  ? 237 GLN C O   1 
ATOM 1256 C CB  . GLN A 1 237 ? 146.977 132.760 178.762 1.00 83.72  ? 237 GLN C CB  1 
ATOM 1257 C CG  . GLN A 1 237 ? 147.975 132.135 177.780 1.00 83.72  ? 237 GLN C CG  1 
ATOM 1258 C CD  . GLN A 1 237 ? 148.429 133.065 176.664 1.00 83.72  ? 237 GLN C CD  1 
ATOM 1259 O OE1 . GLN A 1 237 ? 148.644 134.257 176.867 1.00 83.72  ? 237 GLN C OE1 1 
ATOM 1260 N NE2 . GLN A 1 237 ? 148.575 132.510 175.467 1.00 83.72  ? 237 GLN C NE2 1 
ATOM 1261 N N   . GLN A 1 238 ? 145.625 134.287 181.155 1.00 81.39  ? 238 GLN C N   1 
ATOM 1262 C CA  . GLN A 1 238 ? 144.423 134.976 181.612 1.00 81.39  ? 238 GLN C CA  1 
ATOM 1263 C C   . GLN A 1 238 ? 144.742 136.155 182.522 1.00 81.39  ? 238 GLN C C   1 
ATOM 1264 O O   . GLN A 1 238 ? 144.148 137.228 182.367 1.00 81.39  ? 238 GLN C O   1 
ATOM 1265 C CB  . GLN A 1 238 ? 143.495 133.997 182.331 1.00 81.39  ? 238 GLN C CB  1 
ATOM 1266 C CG  . GLN A 1 238 ? 143.072 132.810 181.486 1.00 81.39  ? 238 GLN C CG  1 
ATOM 1267 C CD  . GLN A 1 238 ? 143.167 131.499 182.236 1.00 81.39  ? 238 GLN C CD  1 
ATOM 1268 O OE1 . GLN A 1 238 ? 143.466 131.475 183.429 1.00 81.39  ? 238 GLN C OE1 1 
ATOM 1269 N NE2 . GLN A 1 238 ? 142.917 130.399 181.538 1.00 81.39  ? 238 GLN C NE2 1 
ATOM 1270 N N   . VAL A 1 239 ? 145.665 135.981 183.471 1.00 74.57  ? 239 VAL C N   1 
ATOM 1271 C CA  . VAL A 1 239 ? 145.896 137.013 184.475 1.00 74.57  ? 239 VAL C CA  1 
ATOM 1272 C C   . VAL A 1 239 ? 146.420 138.299 183.854 1.00 74.57  ? 239 VAL C C   1 
ATOM 1273 O O   . VAL A 1 239 ? 146.067 139.391 184.314 1.00 74.57  ? 239 VAL C O   1 
ATOM 1274 C CB  . VAL A 1 239 ? 146.854 136.501 185.568 1.00 74.57  ? 239 VAL C CB  1 
ATOM 1275 C CG1 . VAL A 1 239 ? 148.207 136.151 184.979 1.00 74.57  ? 239 VAL C CG1 1 
ATOM 1276 C CG2 . VAL A 1 239 ? 147.000 137.533 186.677 1.00 74.57  ? 239 VAL C CG2 1 
ATOM 1277 N N   . VAL A 1 240 ? 147.238 138.203 182.808 1.00 74.70  ? 240 VAL C N   1 
ATOM 1278 C CA  . VAL A 1 240 ? 147.804 139.399 182.199 1.00 74.70  ? 240 VAL C CA  1 
ATOM 1279 C C   . VAL A 1 240 ? 146.728 140.255 181.536 1.00 74.70  ? 240 VAL C C   1 
ATOM 1280 O O   . VAL A 1 240 ? 146.796 141.489 181.588 1.00 74.70  ? 240 VAL C O   1 
ATOM 1281 C CB  . VAL A 1 240 ? 148.903 139.008 181.198 1.00 74.70  ? 240 VAL C CB  1 
ATOM 1282 C CG1 . VAL A 1 240 ? 148.315 138.202 180.061 1.00 74.70  ? 240 VAL C CG1 1 
ATOM 1283 C CG2 . VAL A 1 240 ? 149.577 140.238 180.660 1.00 74.70  ? 240 VAL C CG2 1 
ATOM 1284 N N   . SER A 1 241 ? 145.722 139.630 180.919 1.00 73.93  ? 241 SER C N   1 
ATOM 1285 C CA  . SER A 1 241 ? 144.756 140.376 180.120 1.00 73.93  ? 241 SER C CA  1 
ATOM 1286 C C   . SER A 1 241 ? 143.924 141.311 180.988 1.00 73.93  ? 241 SER C C   1 
ATOM 1287 O O   . SER A 1 241 ? 143.353 142.291 180.496 1.00 73.93  ? 241 SER C O   1 
ATOM 1288 C CB  . SER A 1 241 ? 143.856 139.407 179.355 1.00 73.93  ? 241 SER C CB  1 
ATOM 1289 O OG  . SER A 1 241 ? 142.776 138.976 180.162 1.00 73.93  ? 241 SER C OG  1 
ATOM 1290 N N   . THR A 1 242 ? 143.840 141.018 182.286 1.00 72.67  ? 242 THR C N   1 
ATOM 1291 C CA  . THR A 1 242 ? 143.034 141.839 183.182 1.00 72.67  ? 242 THR C CA  1 
ATOM 1292 C C   . THR A 1 242 ? 143.577 143.261 183.274 1.00 72.67  ? 242 THR C C   1 
ATOM 1293 O O   . THR A 1 242 ? 142.811 144.231 183.266 1.00 72.67  ? 242 THR C O   1 
ATOM 1294 C CB  . THR A 1 242 ? 142.972 141.193 184.565 1.00 72.67  ? 242 THR C CB  1 
ATOM 1295 O OG1 . THR A 1 242 ? 144.233 140.584 184.866 1.00 72.67  ? 242 THR C OG1 1 
ATOM 1296 C CG2 . THR A 1 242 ? 141.884 140.132 184.601 1.00 72.67  ? 242 THR C CG2 1 
ATOM 1297 N N   . PHE A 1 243 ? 144.900 143.407 183.364 1.00 69.07  ? 243 PHE C N   1 
ATOM 1298 C CA  . PHE A 1 243 ? 145.506 144.727 183.493 1.00 69.07  ? 243 PHE C CA  1 
ATOM 1299 C C   . PHE A 1 243 ? 146.292 145.153 182.259 1.00 69.07  ? 243 PHE C C   1 
ATOM 1300 O O   . PHE A 1 243 ? 147.082 146.100 182.346 1.00 69.07  ? 243 PHE C O   1 
ATOM 1301 C CB  . PHE A 1 243 ? 146.415 144.793 184.726 1.00 69.07  ? 243 PHE C CB  1 
ATOM 1302 C CG  . PHE A 1 243 ? 147.487 143.738 184.766 1.00 69.07  ? 243 PHE C CG  1 
ATOM 1303 C CD1 . PHE A 1 243 ? 147.186 142.422 185.068 1.00 69.07  ? 243 PHE C CD1 1 
ATOM 1304 C CD2 . PHE A 1 243 ? 148.808 144.081 184.548 1.00 69.07  ? 243 PHE C CD2 1 
ATOM 1305 C CE1 . PHE A 1 243 ? 148.178 141.465 185.116 1.00 69.07  ? 243 PHE C CE1 1 
ATOM 1306 C CE2 . PHE A 1 243 ? 149.802 143.128 184.594 1.00 69.07  ? 243 PHE C CE2 1 
ATOM 1307 C CZ  . PHE A 1 243 ? 149.486 141.819 184.879 1.00 69.07  ? 243 PHE C CZ  1 
ATOM 1308 N N   . SER A 1 244 ? 146.104 144.489 181.120 1.00 75.97  ? 244 SER C N   1 
ATOM 1309 C CA  . SER A 1 244 ? 146.780 144.890 179.892 1.00 75.97  ? 244 SER C CA  1 
ATOM 1310 C C   . SER A 1 244 ? 146.004 145.991 179.183 1.00 75.97  ? 244 SER C C   1 
ATOM 1311 O O   . SER A 1 244 ? 145.122 146.618 179.778 1.00 75.97  ? 244 SER C O   1 
ATOM 1312 C CB  . SER A 1 244 ? 146.966 143.695 178.957 1.00 75.97  ? 244 SER C CB  1 
ATOM 1313 O OG  . SER A 1 244 ? 147.250 142.516 179.683 1.00 75.97  ? 244 SER C OG  1 
ATOM 1314 N N   . ASP A 1 245 ? 146.359 146.252 177.923 1.00 86.23  ? 245 ASP C N   1 
ATOM 1315 C CA  . ASP A 1 245 ? 145.636 147.172 177.050 1.00 86.23  ? 245 ASP C CA  1 
ATOM 1316 C C   . ASP A 1 245 ? 145.756 148.619 177.511 1.00 86.23  ? 245 ASP C C   1 
ATOM 1317 O O   . ASP A 1 245 ? 145.112 149.508 176.945 1.00 86.23  ? 245 ASP C O   1 
ATOM 1318 C CB  . ASP A 1 245 ? 144.160 146.772 176.945 1.00 86.23  ? 245 ASP C CB  1 
ATOM 1319 C CG  . ASP A 1 245 ? 143.975 145.290 176.683 1.00 86.23  ? 245 ASP C CG  1 
ATOM 1320 O OD1 . ASP A 1 245 ? 144.438 144.809 175.628 1.00 86.23  ? 245 ASP C OD1 1 
ATOM 1321 O OD2 . ASP A 1 245 ? 143.367 144.607 177.534 1.00 86.23  ? 245 ASP C OD2 1 
ATOM 1322 N N   . MET A 1 246 ? 146.569 148.870 178.532 1.00 75.46  ? 246 MET C N   1 
ATOM 1323 C CA  . MET A 1 246 ? 146.790 150.226 179.012 1.00 75.46  ? 246 MET C CA  1 
ATOM 1324 C C   . MET A 1 246 ? 148.047 150.795 178.353 1.00 75.46  ? 246 MET C C   1 
ATOM 1325 O O   . MET A 1 246 ? 148.652 150.176 177.473 1.00 75.46  ? 246 MET C O   1 
ATOM 1326 C CB  . MET A 1 246 ? 146.876 150.239 180.535 1.00 75.46  ? 246 MET C CB  1 
ATOM 1327 C CG  . MET A 1 246 ? 146.182 151.426 181.184 1.00 75.46  ? 246 MET C CG  1 
ATOM 1328 S SD  . MET A 1 246 ? 146.193 151.351 182.985 1.00 75.46  ? 246 MET C SD  1 
ATOM 1329 C CE  . MET A 1 246 ? 146.200 149.581 183.255 1.00 75.46  ? 246 MET C CE  1 
ATOM 1330 N N   . ASN A 1 247 ? 148.450 151.994 178.769 1.00 59.07  ? 247 ASN C N   1 
ATOM 1331 C CA  . ASN A 1 247 ? 149.663 152.630 178.251 1.00 59.07  ? 247 ASN C CA  1 
ATOM 1332 C C   . ASN A 1 247 ? 150.841 152.322 179.179 1.00 59.07  ? 247 ASN C C   1 
ATOM 1333 O O   . ASN A 1 247 ? 151.528 153.200 179.702 1.00 59.07  ? 247 ASN C O   1 
ATOM 1334 C CB  . ASN A 1 247 ? 149.439 154.127 178.074 1.00 59.07  ? 247 ASN C CB  1 
ATOM 1335 C CG  . ASN A 1 247 ? 149.205 154.847 179.390 1.00 59.07  ? 247 ASN C CG  1 
ATOM 1336 O OD1 . ASN A 1 247 ? 148.775 154.245 180.373 1.00 59.07  ? 247 ASN C OD1 1 
ATOM 1337 N ND2 . ASN A 1 247 ? 149.488 156.144 179.413 1.00 59.07  ? 247 ASN C ND2 1 
ATOM 1338 N N   . ILE A 1 248 ? 151.076 151.024 179.361 1.00 49.60  ? 248 ILE C N   1 
ATOM 1339 C CA  . ILE A 1 248 ? 152.112 150.539 180.265 1.00 49.60  ? 248 ILE C CA  1 
ATOM 1340 C C   . ILE A 1 248 ? 153.097 149.664 179.501 1.00 49.60  ? 248 ILE C C   1 
ATOM 1341 O O   . ILE A 1 248 ? 152.849 149.291 178.349 1.00 49.60  ? 248 ILE C O   1 
ATOM 1342 C CB  . ILE A 1 248 ? 151.493 149.768 181.442 1.00 49.60  ? 248 ILE C CB  1 
ATOM 1343 C CG1 . ILE A 1 248 ? 150.998 148.402 180.973 1.00 49.60  ? 248 ILE C CG1 1 
ATOM 1344 C CG2 . ILE A 1 248 ? 150.357 150.559 182.060 1.00 49.60  ? 248 ILE C CG2 1 
ATOM 1345 C CD1 . ILE A 1 248 ? 150.660 147.463 182.101 1.00 49.60  ? 248 ILE C CD1 1 
ATOM 1346 N N   . ILE A 1 249 ? 154.218 149.329 180.138 1.00 39.97  ? 249 ILE C N   1 
ATOM 1347 C CA  . ILE A 1 249 ? 155.230 148.452 179.554 1.00 39.97  ? 249 ILE C CA  1 
ATOM 1348 C C   . ILE A 1 249 ? 155.219 147.156 180.347 1.00 39.97  ? 249 ILE C C   1 
ATOM 1349 O O   . ILE A 1 249 ? 155.399 147.173 181.569 1.00 39.97  ? 249 ILE C O   1 
ATOM 1350 C CB  . ILE A 1 249 ? 156.646 149.053 179.563 1.00 39.97  ? 249 ILE C CB  1 
ATOM 1351 C CG1 . ILE A 1 249 ? 156.789 150.220 178.587 1.00 39.97  ? 249 ILE C CG1 1 
ATOM 1352 C CG2 . ILE A 1 249 ? 157.674 147.981 179.265 1.00 39.97  ? 249 ILE C CG2 1 
ATOM 1353 C CD1 . ILE A 1 249 ? 156.093 151.462 179.005 1.00 39.97  ? 249 ILE C CD1 1 
ATOM 1354 N N   . LEU A 1 250 ? 155.020 146.040 179.663 1.00 37.18  ? 250 LEU C N   1 
ATOM 1355 C CA  . LEU A 1 250 ? 155.207 144.748 180.292 1.00 37.18  ? 250 LEU C CA  1 
ATOM 1356 C C   . LEU A 1 250 ? 156.628 144.253 180.049 1.00 37.18  ? 250 LEU C C   1 
ATOM 1357 O O   . LEU A 1 250 ? 157.275 144.596 179.058 1.00 37.18  ? 250 LEU C O   1 
ATOM 1358 C CB  . LEU A 1 250 ? 154.191 143.740 179.771 1.00 37.18  ? 250 LEU C CB  1 
ATOM 1359 C CG  . LEU A 1 250 ? 152.895 143.702 180.571 1.00 37.18  ? 250 LEU C CG  1 
ATOM 1360 C CD1 . LEU A 1 250 ? 151.905 144.720 180.041 1.00 37.18  ? 250 LEU C CD1 1 
ATOM 1361 C CD2 . LEU A 1 250 ? 152.320 142.315 180.543 1.00 37.18  ? 250 LEU C CD2 1 
ATOM 1362 N N   . ALA A 1 251 ? 157.114 143.437 180.977 1.00 37.46  ? 251 ALA C N   1 
ATOM 1363 C CA  . ALA A 1 251 ? 158.462 142.900 180.892 1.00 37.46  ? 251 ALA C CA  1 
ATOM 1364 C C   . ALA A 1 251 ? 158.564 141.730 181.856 1.00 37.46  ? 251 ALA C C   1 
ATOM 1365 O O   . ALA A 1 251 ? 157.970 141.743 182.937 1.00 37.46  ? 251 ALA C O   1 
ATOM 1366 C CB  . ALA A 1 251 ? 159.516 143.959 181.218 1.00 37.46  ? 251 ALA C CB  1 
ATOM 1367 N N   . GLY A 1 252 ? 159.315 140.721 181.451 1.00 52.44  ? 252 GLY C N   1 
ATOM 1368 C CA  . GLY A 1 252 ? 159.538 139.561 182.284 1.00 52.44  ? 252 GLY C CA  1 
ATOM 1369 C C   . GLY A 1 252 ? 159.221 138.290 181.524 1.00 52.44  ? 252 GLY C C   1 
ATOM 1370 O O   . GLY A 1 252 ? 159.176 138.280 180.299 1.00 52.44  ? 252 GLY C O   1 
ATOM 1371 N N   . GLY A 1 253 ? 158.992 137.228 182.286 1.00 58.62  ? 253 GLY C N   1 
ATOM 1372 C CA  . GLY A 1 253 ? 158.746 135.928 181.699 1.00 58.62  ? 253 GLY C CA  1 
ATOM 1373 C C   . GLY A 1 253 ? 158.438 134.910 182.778 1.00 58.62  ? 253 GLY C C   1 
ATOM 1374 O O   . GLY A 1 253 ? 157.932 135.247 183.850 1.00 58.62  ? 253 GLY C O   1 
ATOM 1375 N N   . GLN A 1 254 ? 158.749 133.657 182.467 1.00 63.83  ? 254 GLN C N   1 
ATOM 1376 C CA  . GLN A 1 254 ? 158.496 132.542 183.366 1.00 63.83  ? 254 GLN C CA  1 
ATOM 1377 C C   . GLN A 1 254 ? 159.788 132.110 184.047 1.00 63.83  ? 254 GLN C C   1 
ATOM 1378 O O   . GLN A 1 254 ? 160.844 132.042 183.413 1.00 63.83  ? 254 GLN C O   1 
ATOM 1379 C CB  . GLN A 1 254 ? 157.882 131.365 182.609 1.00 63.83  ? 254 GLN C CB  1 
ATOM 1380 C CG  . GLN A 1 254 ? 156.639 131.728 181.823 1.00 63.83  ? 254 GLN C CG  1 
ATOM 1381 C CD  . GLN A 1 254 ? 155.982 130.523 181.188 1.00 63.83  ? 254 GLN C CD  1 
ATOM 1382 O OE1 . GLN A 1 254 ? 156.397 129.386 181.412 1.00 63.83  ? 254 GLN C OE1 1 
ATOM 1383 N NE2 . GLN A 1 254 ? 154.956 130.764 180.382 1.00 63.83  ? 254 GLN C NE2 1 
ATOM 1384 N N   . VAL A 1 255 ? 159.696 131.825 185.346 1.00 63.59  ? 255 VAL C N   1 
ATOM 1385 C CA  . VAL A 1 255 ? 160.856 131.442 186.145 1.00 63.59  ? 255 VAL C CA  1 
ATOM 1386 C C   . VAL A 1 255 ? 160.551 130.145 186.884 1.00 63.59  ? 255 VAL C C   1 
ATOM 1387 O O   . VAL A 1 255 ? 159.481 129.555 186.702 1.00 63.59  ? 255 VAL C O   1 
ATOM 1388 C CB  . VAL A 1 255 ? 161.249 132.563 187.124 1.00 63.59  ? 255 VAL C CB  1 
ATOM 1389 C CG1 . VAL A 1 255 ? 161.366 133.884 186.387 1.00 63.59  ? 255 VAL C CG1 1 
ATOM 1390 C CG2 . VAL A 1 255 ? 160.236 132.664 188.251 1.00 63.59  ? 255 VAL C CG2 1 
ATOM 1391 N N   . ASP A 1 256 ? 161.487 129.689 187.720 1.00 72.11  ? 256 ASP C N   1 
ATOM 1392 C CA  . ASP A 1 256 ? 161.319 128.398 188.382 1.00 72.11  ? 256 ASP C CA  1 
ATOM 1393 C C   . ASP A 1 256 ? 160.376 128.489 189.575 1.00 72.11  ? 256 ASP C C   1 
ATOM 1394 O O   . ASP A 1 256 ? 159.305 127.874 189.581 1.00 72.11  ? 256 ASP C O   1 
ATOM 1395 C CB  . ASP A 1 256 ? 162.674 127.850 188.835 1.00 72.11  ? 256 ASP C CB  1 
ATOM 1396 C CG  . ASP A 1 256 ? 163.753 128.019 187.794 1.00 72.11  ? 256 ASP C CG  1 
ATOM 1397 O OD1 . ASP A 1 256 ? 163.505 127.684 186.617 1.00 72.11  ? 256 ASP C OD1 1 
ATOM 1398 O OD2 . ASP A 1 256 ? 164.852 128.484 188.158 1.00 72.11  ? 256 ASP C OD2 1 
ATOM 1399 N N   . ASN A 1 257 ? 160.755 129.253 190.596 1.00 73.09  ? 257 ASN C N   1 
ATOM 1400 C CA  . ASN A 1 257 ? 160.020 129.233 191.852 1.00 73.09  ? 257 ASN C CA  1 
ATOM 1401 C C   . ASN A 1 257 ? 160.275 130.528 192.608 1.00 73.09  ? 257 ASN C C   1 
ATOM 1402 O O   . ASN A 1 257 ? 161.103 131.352 192.213 1.00 73.09  ? 257 ASN C O   1 
ATOM 1403 C CB  . ASN A 1 257 ? 160.410 128.020 192.700 1.00 73.09  ? 257 ASN C CB  1 
ATOM 1404 C CG  . ASN A 1 257 ? 159.208 127.303 193.277 1.00 73.09  ? 257 ASN C CG  1 
ATOM 1405 O OD1 . ASN A 1 257 ? 158.149 127.899 193.472 1.00 73.09  ? 257 ASN C OD1 1 
ATOM 1406 N ND2 . ASN A 1 257 ? 159.363 126.012 193.545 1.00 73.09  ? 257 ASN C ND2 1 
ATOM 1407 N N   . LEU A 1 258 ? 159.547 130.690 193.710 1.00 71.27  ? 258 LEU C N   1 
ATOM 1408 C CA  . LEU A 1 258 ? 159.621 131.875 194.550 1.00 71.27  ? 258 LEU C CA  1 
ATOM 1409 C C   . LEU A 1 258 ? 160.349 131.529 195.840 1.00 71.27  ? 258 LEU C C   1 
ATOM 1410 O O   . LEU A 1 258 ? 160.340 130.373 196.275 1.00 71.27  ? 258 LEU C O   1 
ATOM 1411 C CB  . LEU A 1 258 ? 158.226 132.408 194.878 1.00 71.27  ? 258 LEU C CB  1 
ATOM 1412 C CG  . LEU A 1 258 ? 157.561 133.318 193.846 1.00 71.27  ? 258 LEU C CG  1 
ATOM 1413 C CD1 . LEU A 1 258 ? 156.441 134.110 194.497 1.00 71.27  ? 258 LEU C CD1 1 
ATOM 1414 C CD2 . LEU A 1 258 ? 158.564 134.231 193.171 1.00 71.27  ? 258 LEU C CD2 1 
ATOM 1415 N N   . SER A 1 259 ? 160.977 132.530 196.453 1.00 73.18  ? 259 SER C N   1 
ATOM 1416 C CA  . SER A 1 259 ? 161.723 132.314 197.687 1.00 73.18  ? 259 SER C CA  1 
ATOM 1417 C C   . SER A 1 259 ? 161.146 133.080 198.872 1.00 73.18  ? 259 SER C C   1 
ATOM 1418 O O   . SER A 1 259 ? 160.909 132.489 199.929 1.00 73.18  ? 259 SER C O   1 
ATOM 1419 C CB  . SER A 1 259 ? 163.196 132.692 197.488 1.00 73.18  ? 259 SER C CB  1 
ATOM 1420 O OG  . SER A 1 259 ? 163.378 134.095 197.532 1.00 73.18  ? 259 SER C OG  1 
ATOM 1421 N N   . SER A 1 260 ? 160.910 134.383 198.723 1.00 75.83  ? 260 SER C N   1 
ATOM 1422 C CA  . SER A 1 260 ? 160.467 135.192 199.851 1.00 75.83  ? 260 SER C CA  1 
ATOM 1423 C C   . SER A 1 260 ? 159.652 136.381 199.367 1.00 75.83  ? 260 SER C C   1 
ATOM 1424 O O   . SER A 1 260 ? 160.065 137.087 198.443 1.00 75.83  ? 260 SER C O   1 
ATOM 1425 C CB  . SER A 1 260 ? 161.665 135.680 200.672 1.00 75.83  ? 260 SER C CB  1 
ATOM 1426 O OG  . SER A 1 260 ? 162.478 136.553 199.909 1.00 75.83  ? 260 SER C OG  1 
ATOM 1427 N N   . LEU A 1 261 ? 158.499 136.596 199.997 1.00 75.04  ? 261 LEU C N   1 
ATOM 1428 C CA  . LEU A 1 261 ? 157.681 137.781 199.781 1.00 75.04  ? 261 LEU C CA  1 
ATOM 1429 C C   . LEU A 1 261 ? 157.241 138.327 201.131 1.00 75.04  ? 261 LEU C C   1 
ATOM 1430 O O   . LEU A 1 261 ? 156.875 137.562 202.028 1.00 75.04  ? 261 LEU C O   1 
ATOM 1431 C CB  . LEU A 1 261 ? 156.459 137.470 198.912 1.00 75.04  ? 261 LEU C CB  1 
ATOM 1432 C CG  . LEU A 1 261 ? 155.788 138.658 198.220 1.00 75.04  ? 261 LEU C CG  1 
ATOM 1433 C CD1 . LEU A 1 261 ? 156.818 139.599 197.628 1.00 75.04  ? 261 LEU C CD1 1 
ATOM 1434 C CD2 . LEU A 1 261 ? 154.834 138.173 197.148 1.00 75.04  ? 261 LEU C CD2 1 
ATOM 1435 N N   . THR A 1 262 ? 157.276 139.653 201.272 1.00 84.03  ? 262 THR C N   1 
ATOM 1436 C CA  . THR A 1 262 ? 156.943 140.301 202.541 1.00 84.03  ? 262 THR C CA  1 
ATOM 1437 C C   . THR A 1 262 ? 155.492 140.770 202.503 1.00 84.03  ? 262 THR C C   1 
ATOM 1438 O O   . THR A 1 262 ? 155.179 141.933 202.236 1.00 84.03  ? 262 THR C O   1 
ATOM 1439 C CB  . THR A 1 262 ? 157.899 141.451 202.828 1.00 84.03  ? 262 THR C CB  1 
ATOM 1440 O OG1 . THR A 1 262 ? 157.867 142.387 201.743 1.00 84.03  ? 262 THR C OG1 1 
ATOM 1441 C CG2 . THR A 1 262 ? 159.315 140.932 203.010 1.00 84.03  ? 262 THR C CG2 1 
ATOM 1442 N N   . SER A 1 263 ? 154.588 139.831 202.779 1.00 112.46 ? 263 SER C N   1 
ATOM 1443 C CA  . SER A 1 263 ? 153.178 140.136 202.953 1.00 112.46 ? 263 SER C CA  1 
ATOM 1444 C C   . SER A 1 263 ? 152.694 139.932 204.381 1.00 112.46 ? 263 SER C C   1 
ATOM 1445 O O   . SER A 1 263 ? 151.613 140.426 204.724 1.00 112.46 ? 263 SER C O   1 
ATOM 1446 C CB  . SER A 1 263 ? 152.322 139.285 202.003 1.00 112.46 ? 263 SER C CB  1 
ATOM 1447 O OG  . SER A 1 263 ? 152.488 137.906 202.273 1.00 112.46 ? 263 SER C OG  1 
ATOM 1448 N N   . GLU A 1 264 ? 153.454 139.217 205.214 1.00 133.08 ? 264 GLU C N   1 
ATOM 1449 C CA  . GLU A 1 264 ? 153.190 139.054 206.643 1.00 133.08 ? 264 GLU C CA  1 
ATOM 1450 C C   . GLU A 1 264 ? 151.859 138.365 206.929 1.00 133.08 ? 264 GLU C C   1 
ATOM 1451 O O   . GLU A 1 264 ? 151.333 138.468 208.042 1.00 133.08 ? 264 GLU C O   1 
ATOM 1452 C CB  . GLU A 1 264 ? 153.250 140.402 207.374 1.00 133.08 ? 264 GLU C CB  1 
ATOM 1453 C CG  . GLU A 1 264 ? 154.645 140.800 207.831 1.00 133.08 ? 264 GLU C CG  1 
ATOM 1454 C CD  . GLU A 1 264 ? 154.637 142.014 208.740 1.00 133.08 ? 264 GLU C CD  1 
ATOM 1455 O OE1 . GLU A 1 264 ? 153.560 142.624 208.910 1.00 133.08 ? 264 GLU C OE1 1 
ATOM 1456 O OE2 . GLU A 1 264 ? 155.707 142.359 209.283 1.00 133.08 ? 264 GLU C OE2 1 
ATOM 1457 N N   . LYS A 1 265 ? 151.293 137.654 205.948 1.00 134.99 ? 265 LYS C N   1 
ATOM 1458 C CA  . LYS A 1 265 ? 150.033 136.958 206.181 1.00 134.99 ? 265 LYS C CA  1 
ATOM 1459 C C   . LYS A 1 265 ? 149.979 135.588 205.510 1.00 134.99 ? 265 LYS C C   1 
ATOM 1460 O O   . LYS A 1 265 ? 148.899 134.990 205.438 1.00 134.99 ? 265 LYS C O   1 
ATOM 1461 C CB  . LYS A 1 265 ? 148.846 137.806 205.705 1.00 134.99 ? 265 LYS C CB  1 
ATOM 1462 C CG  . LYS A 1 265 ? 148.390 138.850 206.712 1.00 134.99 ? 265 LYS C CG  1 
ATOM 1463 C CD  . LYS A 1 265 ? 147.262 139.704 206.160 1.00 134.99 ? 265 LYS C CD  1 
ATOM 1464 C CE  . LYS A 1 265 ? 146.845 140.774 207.156 1.00 134.99 ? 265 LYS C CE  1 
ATOM 1465 N NZ  . LYS A 1 265 ? 145.859 141.726 206.574 1.00 134.99 ? 265 LYS C NZ  1 
ATOM 1466 N N   . ASN A 1 266 ? 151.104 135.072 205.020 1.00 123.35 ? 266 ASN C N   1 
ATOM 1467 C CA  . ASN A 1 266 ? 151.074 133.781 204.345 1.00 123.35 ? 266 ASN C CA  1 
ATOM 1468 C C   . ASN A 1 266 ? 152.430 133.086 204.387 1.00 123.35 ? 266 ASN C C   1 
ATOM 1469 O O   . ASN A 1 266 ? 153.415 133.605 203.846 1.00 123.35 ? 266 ASN C O   1 
ATOM 1470 C CB  . ASN A 1 266 ? 150.617 133.950 202.893 1.00 123.35 ? 266 ASN C CB  1 
ATOM 1471 C CG  . ASN A 1 266 ? 151.329 135.087 202.184 1.00 123.35 ? 266 ASN C CG  1 
ATOM 1472 O OD1 . ASN A 1 266 ? 152.138 135.797 202.780 1.00 123.35 ? 266 ASN C OD1 1 
ATOM 1473 N ND2 . ASN A 1 266 ? 151.033 135.261 200.901 1.00 123.35 ? 266 ASN C ND2 1 
ATOM 1474 N N   . PRO A 1 267 ? 152.527 131.920 205.022 1.00 111.00 ? 267 PRO C N   1 
ATOM 1475 C CA  . PRO A 1 267 ? 153.736 131.097 204.864 1.00 111.00 ? 267 PRO C CA  1 
ATOM 1476 C C   . PRO A 1 267 ? 153.806 130.559 203.444 1.00 111.00 ? 267 PRO C C   1 
ATOM 1477 O O   . PRO A 1 267 ? 152.901 129.862 202.980 1.00 111.00 ? 267 PRO C O   1 
ATOM 1478 C CB  . PRO A 1 267 ? 153.557 129.976 205.896 1.00 111.00 ? 267 PRO C CB  1 
ATOM 1479 C CG  . PRO A 1 267 ? 152.156 130.053 206.375 1.00 111.00 ? 267 PRO C CG  1 
ATOM 1480 C CD  . PRO A 1 267 ? 151.523 131.322 205.917 1.00 111.00 ? 267 PRO C CD  1 
ATOM 1481 N N   . LEU A 1 268 ? 154.892 130.895 202.751 1.00 100.76 ? 268 LEU C N   1 
ATOM 1482 C CA  . LEU A 1 268 ? 154.984 130.650 201.316 1.00 100.76 ? 268 LEU C CA  1 
ATOM 1483 C C   . LEU A 1 268 ? 154.965 129.153 201.024 1.00 100.76 ? 268 LEU C C   1 
ATOM 1484 O O   . LEU A 1 268 ? 155.682 128.376 201.663 1.00 100.76 ? 268 LEU C O   1 
ATOM 1485 C CB  . LEU A 1 268 ? 156.250 131.296 200.759 1.00 100.76 ? 268 LEU C CB  1 
ATOM 1486 C CG  . LEU A 1 268 ? 156.311 131.519 199.246 1.00 100.76 ? 268 LEU C CG  1 
ATOM 1487 C CD1 . LEU A 1 268 ? 157.085 132.790 198.940 1.00 100.76 ? 268 LEU C CD1 1 
ATOM 1488 C CD2 . LEU A 1 268 ? 156.938 130.330 198.535 1.00 100.76 ? 268 LEU C CD2 1 
ATOM 1489 N N   . ASP A 1 269 ? 154.142 128.754 200.057 1.00 106.71 ? 269 ASP C N   1 
ATOM 1490 C CA  . ASP A 1 269 ? 154.046 127.360 199.635 1.00 106.71 ? 269 ASP C CA  1 
ATOM 1491 C C   . ASP A 1 269 ? 154.904 127.167 198.391 1.00 106.71 ? 269 ASP C C   1 
ATOM 1492 O O   . ASP A 1 269 ? 154.714 127.855 197.383 1.00 106.71 ? 269 ASP C O   1 
ATOM 1493 C CB  . ASP A 1 269 ? 152.591 126.985 199.368 1.00 106.71 ? 269 ASP C CB  1 
ATOM 1494 C CG  . ASP A 1 269 ? 152.383 125.486 199.267 1.00 106.71 ? 269 ASP C CG  1 
ATOM 1495 O OD1 . ASP A 1 269 ? 153.375 124.735 199.376 1.00 106.71 ? 269 ASP C OD1 1 
ATOM 1496 O OD2 . ASP A 1 269 ? 151.224 125.059 199.079 1.00 106.71 ? 269 ASP C OD2 1 
ATOM 1497 N N   . ILE A 1 270 ? 155.852 126.230 198.458 1.00 94.69  ? 270 ILE C N   1 
ATOM 1498 C CA  . ILE A 1 270 ? 156.805 126.065 197.365 1.00 94.69  ? 270 ILE C CA  1 
ATOM 1499 C C   . ILE A 1 270 ? 156.160 125.376 196.166 1.00 94.69  ? 270 ILE C C   1 
ATOM 1500 O O   . ILE A 1 270 ? 156.599 125.565 195.025 1.00 94.69  ? 270 ILE C O   1 
ATOM 1501 C CB  . ILE A 1 270 ? 158.049 125.302 197.860 1.00 94.69  ? 270 ILE C CB  1 
ATOM 1502 C CG1 . ILE A 1 270 ? 159.198 125.443 196.861 1.00 94.69  ? 270 ILE C CG1 1 
ATOM 1503 C CG2 . ILE A 1 270 ? 157.728 123.837 198.107 1.00 94.69  ? 270 ILE C CG2 1 
ATOM 1504 C CD1 . ILE A 1 270 ? 159.713 126.856 196.735 1.00 94.69  ? 270 ILE C CD1 1 
ATOM 1505 N N   . ASP A 1 271 ? 155.116 124.576 196.390 1.00 96.30  ? 271 ASP C N   1 
ATOM 1506 C CA  . ASP A 1 271 ? 154.520 123.792 195.315 1.00 96.30  ? 271 ASP C CA  1 
ATOM 1507 C C   . ASP A 1 271 ? 153.506 124.567 194.484 1.00 96.30  ? 271 ASP C C   1 
ATOM 1508 O O   . ASP A 1 271 ? 153.146 124.108 193.395 1.00 96.30  ? 271 ASP C O   1 
ATOM 1509 C CB  . ASP A 1 271 ? 153.851 122.542 195.888 1.00 96.30  ? 271 ASP C CB  1 
ATOM 1510 C CG  . ASP A 1 271 ? 154.848 121.567 196.477 1.00 96.30  ? 271 ASP C CG  1 
ATOM 1511 O OD1 . ASP A 1 271 ? 155.207 121.727 197.663 1.00 96.30  ? 271 ASP C OD1 1 
ATOM 1512 O OD2 . ASP A 1 271 ? 155.274 120.643 195.754 1.00 96.30  ? 271 ASP C OD2 1 
ATOM 1513 N N   . ALA A 1 272 ? 153.040 125.718 194.955 1.00 91.90  ? 272 ALA C N   1 
ATOM 1514 C CA  . ALA A 1 272 ? 151.981 126.447 194.276 1.00 91.90  ? 272 ALA C CA  1 
ATOM 1515 C C   . ALA A 1 272 ? 152.555 127.442 193.275 1.00 91.90  ? 272 ALA C C   1 
ATOM 1516 O O   . ALA A 1 272 ? 153.607 128.044 193.500 1.00 91.90  ? 272 ALA C O   1 
ATOM 1517 C CB  . ALA A 1 272 ? 151.096 127.176 195.288 1.00 91.90  ? 272 ALA C CB  1 
ATOM 1518 N N   . SER A 1 273 ? 151.848 127.606 192.162 1.00 80.27  ? 273 SER C N   1 
ATOM 1519 C CA  . SER A 1 273 ? 152.243 128.537 191.117 1.00 80.27  ? 273 SER C CA  1 
ATOM 1520 C C   . SER A 1 273 ? 151.464 129.840 191.240 1.00 80.27  ? 273 SER C C   1 
ATOM 1521 O O   . SER A 1 273 ? 150.457 129.928 191.946 1.00 80.27  ? 273 SER C O   1 
ATOM 1522 C CB  . SER A 1 273 ? 152.017 127.926 189.735 1.00 80.27  ? 273 SER C CB  1 
ATOM 1523 O OG  . SER A 1 273 ? 150.656 127.591 189.544 1.00 80.27  ? 273 SER C OG  1 
ATOM 1524 N N   . GLY A 1 274 ? 151.943 130.859 190.538 1.00 67.25  ? 274 GLY C N   1 
ATOM 1525 C CA  . GLY A 1 274 ? 151.288 132.153 190.585 1.00 67.25  ? 274 GLY C CA  1 
ATOM 1526 C C   . GLY A 1 274 ? 152.043 133.168 189.760 1.00 67.25  ? 274 GLY C C   1 
ATOM 1527 O O   . GLY A 1 274 ? 152.968 132.837 189.011 1.00 67.25  ? 274 GLY C O   1 
ATOM 1528 N N   . VAL A 1 275 ? 151.629 134.422 189.912 1.00 56.14  ? 275 VAL C N   1 
ATOM 1529 C CA  . VAL A 1 275 ? 152.208 135.550 189.192 1.00 56.14  ? 275 VAL C CA  1 
ATOM 1530 C C   . VAL A 1 275 ? 152.626 136.592 190.219 1.00 56.14  ? 275 VAL C C   1 
ATOM 1531 O O   . VAL A 1 275 ? 151.822 136.990 191.072 1.00 56.14  ? 275 VAL C O   1 
ATOM 1532 C CB  . VAL A 1 275 ? 151.225 136.142 188.176 1.00 56.14  ? 275 VAL C CB  1 
ATOM 1533 C CG1 . VAL A 1 275 ? 151.867 137.286 187.427 1.00 56.14  ? 275 VAL C CG1 1 
ATOM 1534 C CG2 . VAL A 1 275 ? 150.769 135.067 187.213 1.00 56.14  ? 275 VAL C CG2 1 
ATOM 1535 N N   . VAL A 1 276 ? 153.879 137.032 190.143 1.00 51.48  ? 276 VAL C N   1 
ATOM 1536 C CA  . VAL A 1 276 ? 154.426 138.040 191.042 1.00 51.48  ? 276 VAL C CA  1 
ATOM 1537 C C   . VAL A 1 276 ? 155.224 139.041 190.223 1.00 51.48  ? 276 VAL C C   1 
ATOM 1538 O O   . VAL A 1 276 ? 155.634 138.747 189.096 1.00 51.48  ? 276 VAL C O   1 
ATOM 1539 C CB  . VAL A 1 276 ? 155.314 137.411 192.131 1.00 51.48  ? 276 VAL C CB  1 
ATOM 1540 C CG1 . VAL A 1 276 ? 154.460 136.823 193.228 1.00 51.48  ? 276 VAL C CG1 1 
ATOM 1541 C CG2 . VAL A 1 276 ? 156.202 136.350 191.522 1.00 51.48  ? 276 VAL C CG2 1 
ATOM 1542 N N   . GLY A 1 277 ? 155.441 140.221 190.790 1.00 44.30  ? 277 GLY C N   1 
ATOM 1543 C CA  . GLY A 1 277 ? 156.261 141.213 190.120 1.00 44.30  ? 277 GLY C CA  1 
ATOM 1544 C C   . GLY A 1 277 ? 156.136 142.561 190.790 1.00 44.30  ? 277 GLY C C   1 
ATOM 1545 O O   . GLY A 1 277 ? 155.414 142.729 191.776 1.00 44.30  ? 277 GLY C O   1 
ATOM 1546 N N   . LEU A 1 278 ? 156.857 143.527 190.233 1.00 39.36  ? 278 LEU C N   1 
ATOM 1547 C CA  . LEU A 1 278 ? 156.808 144.906 190.683 1.00 39.36  ? 278 LEU C CA  1 
ATOM 1548 C C   . LEU A 1 278 ? 155.895 145.705 189.764 1.00 39.36  ? 278 LEU C C   1 
ATOM 1549 O O   . LEU A 1 278 ? 155.688 145.353 188.601 1.00 39.36  ? 278 LEU C O   1 
ATOM 1550 C CB  . LEU A 1 278 ? 158.204 145.541 190.714 1.00 39.36  ? 278 LEU C CB  1 
ATOM 1551 C CG  . LEU A 1 278 ? 158.978 145.489 192.033 1.00 39.36  ? 278 LEU C CG  1 
ATOM 1552 C CD1 . LEU A 1 278 ? 159.101 144.068 192.547 1.00 39.36  ? 278 LEU C CD1 1 
ATOM 1553 C CD2 . LEU A 1 278 ? 160.349 146.125 191.873 1.00 39.36  ? 278 LEU C CD2 1 
ATOM 1554 N N   . SER A 1 279 ? 155.342 146.787 190.304 1.00 40.10  ? 279 SER C N   1 
ATOM 1555 C CA  . SER A 1 279 ? 154.444 147.668 189.561 1.00 40.10  ? 279 SER C CA  1 
ATOM 1556 C C   . SER A 1 279 ? 154.920 149.104 189.752 1.00 40.10  ? 279 SER C C   1 
ATOM 1557 O O   . SER A 1 279 ? 154.468 149.796 190.668 1.00 40.10  ? 279 SER C O   1 
ATOM 1558 C CB  . SER A 1 279 ? 153.003 147.499 190.024 1.00 40.10  ? 279 SER C CB  1 
ATOM 1559 O OG  . SER A 1 279 ? 152.749 148.292 191.169 1.00 40.10  ? 279 SER C OG  1 
ATOM 1560 N N   . PHE A 1 280 ? 155.827 149.546 188.888 1.00 35.36  ? 280 PHE C N   1 
ATOM 1561 C CA  . PHE A 1 280 ? 156.339 150.906 188.955 1.00 35.36  ? 280 PHE C CA  1 
ATOM 1562 C C   . PHE A 1 280 ? 155.222 151.900 188.674 1.00 35.36  ? 280 PHE C C   1 
ATOM 1563 O O   . PHE A 1 280 ? 154.352 151.657 187.835 1.00 35.36  ? 280 PHE C O   1 
ATOM 1564 C CB  . PHE A 1 280 ? 157.476 151.109 187.952 1.00 35.36  ? 280 PHE C CB  1 
ATOM 1565 C CG  . PHE A 1 280 ? 158.759 150.421 188.329 1.00 35.36  ? 280 PHE C CG  1 
ATOM 1566 C CD1 . PHE A 1 280 ? 158.781 149.076 188.656 1.00 35.36  ? 280 PHE C CD1 1 
ATOM 1567 C CD2 . PHE A 1 280 ? 159.949 151.123 188.343 1.00 35.36  ? 280 PHE C CD2 1 
ATOM 1568 C CE1 . PHE A 1 280 ? 159.958 148.451 188.996 1.00 35.36  ? 280 PHE C CE1 1 
ATOM 1569 C CE2 . PHE A 1 280 ? 161.129 150.502 188.682 1.00 35.36  ? 280 PHE C CE2 1 
ATOM 1570 C CZ  . PHE A 1 280 ? 161.133 149.163 189.009 1.00 35.36  ? 280 PHE C CZ  1 
ATOM 1571 N N   . SER A 1 281 ? 155.246 153.023 189.386 1.00 46.75  ? 281 SER C N   1 
ATOM 1572 C CA  . SER A 1 281 ? 154.224 154.044 189.226 1.00 46.75  ? 281 SER C CA  1 
ATOM 1573 C C   . SER A 1 281 ? 154.808 155.395 189.601 1.00 46.75  ? 281 SER C C   1 
ATOM 1574 O O   . SER A 1 281 ? 155.470 155.527 190.633 1.00 46.75  ? 281 SER C O   1 
ATOM 1575 C CB  . SER A 1 281 ? 152.994 153.741 190.086 1.00 46.75  ? 281 SER C CB  1 
ATOM 1576 O OG  . SER A 1 281 ? 153.375 153.339 191.390 1.00 46.75  ? 281 SER C OG  1 
ATOM 1577 N N   . GLY A 1 282 ? 154.558 156.389 188.760 1.00 54.36  ? 282 GLY C N   1 
ATOM 1578 C CA  . GLY A 1 282 ? 155.080 157.715 189.015 1.00 54.36  ? 282 GLY C CA  1 
ATOM 1579 C C   . GLY A 1 282 ? 154.726 158.653 187.888 1.00 54.36  ? 282 GLY C C   1 
ATOM 1580 O O   . GLY A 1 282 ? 153.966 158.301 186.985 1.00 54.36  ? 282 GLY C O   1 
ATOM 1581 N N   . HIS A 1 283 ? 155.291 159.858 187.946 1.00 61.26  ? 283 HIS C N   1 
ATOM 1582 C CA  . HIS A 1 283 ? 155.040 160.871 186.933 1.00 61.26  ? 283 HIS C CA  1 
ATOM 1583 C C   . HIS A 1 283 ? 156.214 161.103 185.995 1.00 61.26  ? 283 HIS C C   1 
ATOM 1584 O O   . HIS A 1 283 ? 156.025 161.743 184.955 1.00 61.26  ? 283 HIS C O   1 
ATOM 1585 C CB  . HIS A 1 283 ? 154.659 162.207 187.590 1.00 61.26  ? 283 HIS C CB  1 
ATOM 1586 C CG  . HIS A 1 283 ? 153.911 163.136 186.686 1.00 61.26  ? 283 HIS C CG  1 
ATOM 1587 N ND1 . HIS A 1 283 ? 154.035 163.104 185.313 1.00 61.26  ? 283 HIS C ND1 1 
ATOM 1588 C CD2 . HIS A 1 283 ? 153.030 164.128 186.959 1.00 61.26  ? 283 HIS C CD2 1 
ATOM 1589 C CE1 . HIS A 1 283 ? 153.263 164.033 184.780 1.00 61.26  ? 283 HIS C CE1 1 
ATOM 1590 N NE2 . HIS A 1 283 ? 152.642 164.669 185.757 1.00 61.26  ? 283 HIS C NE2 1 
ATOM 1591 N N   . ARG A 1 284 ? 157.408 160.610 186.318 1.00 59.04  ? 284 ARG C N   1 
ATOM 1592 C CA  . ARG A 1 284 ? 158.571 160.785 185.462 1.00 59.04  ? 284 ARG C CA  1 
ATOM 1593 C C   . ARG A 1 284 ? 159.204 159.471 185.034 1.00 59.04  ? 284 ARG C C   1 
ATOM 1594 O O   . ARG A 1 284 ? 160.285 159.490 184.436 1.00 59.04  ? 284 ARG C O   1 
ATOM 1595 C CB  . ARG A 1 284 ? 159.626 161.651 186.164 1.00 59.04  ? 284 ARG C CB  1 
ATOM 1596 C CG  . ARG A 1 284 ? 159.569 163.118 185.785 1.00 59.04  ? 284 ARG C CG  1 
ATOM 1597 C CD  . ARG A 1 284 ? 158.502 163.849 186.582 1.00 59.04  ? 284 ARG C CD  1 
ATOM 1598 N NE  . ARG A 1 284 ? 158.759 163.793 188.017 1.00 59.04  ? 284 ARG C NE  1 
ATOM 1599 C CZ  . ARG A 1 284 ? 159.699 164.491 188.640 1.00 59.04  ? 284 ARG C CZ  1 
ATOM 1600 N NH1 . ARG A 1 284 ? 160.488 165.327 187.985 1.00 59.04  ? 284 ARG C NH1 1 
ATOM 1601 N NH2 . ARG A 1 284 ? 159.848 164.350 189.954 1.00 59.04  ? 284 ARG C NH2 1 
ATOM 1602 N N   . ILE A 1 285 ? 158.568 158.335 185.312 1.00 45.40  ? 285 ILE C N   1 
ATOM 1603 C CA  . ILE A 1 285 ? 159.138 157.041 184.962 1.00 45.40  ? 285 ILE C CA  1 
ATOM 1604 C C   . ILE A 1 285 ? 159.005 156.817 183.464 1.00 45.40  ? 285 ILE C C   1 
ATOM 1605 O O   . ILE A 1 285 ? 157.943 156.419 182.975 1.00 45.40  ? 285 ILE C O   1 
ATOM 1606 C CB  . ILE A 1 285 ? 158.467 155.902 185.747 1.00 45.40  ? 285 ILE C CB  1 
ATOM 1607 C CG1 . ILE A 1 285 ? 158.632 156.120 187.249 1.00 45.40  ? 285 ILE C CG1 1 
ATOM 1608 C CG2 . ILE A 1 285 ? 159.050 154.563 185.346 1.00 45.40  ? 285 ILE C CG2 1 
ATOM 1609 C CD1 . ILE A 1 285 ? 157.924 155.084 188.088 1.00 45.40  ? 285 ILE C CD1 1 
ATOM 1610 N N   . GLN A 1 286 ? 160.078 157.074 182.729 1.00 39.51  ? 286 GLN C N   1 
ATOM 1611 C CA  . GLN A 1 286 ? 160.132 156.781 181.308 1.00 39.51  ? 286 GLN C CA  1 
ATOM 1612 C C   . GLN A 1 286 ? 160.574 155.338 181.094 1.00 39.51  ? 286 GLN C C   1 
ATOM 1613 O O   . GLN A 1 286 ? 161.184 154.715 181.966 1.00 39.51  ? 286 GLN C O   1 
ATOM 1614 C CB  . GLN A 1 286 ? 161.082 157.745 180.600 1.00 39.51  ? 286 GLN C CB  1 
ATOM 1615 C CG  . GLN A 1 286 ? 160.556 159.165 180.534 1.00 39.51  ? 286 GLN C CG  1 
ATOM 1616 C CD  . GLN A 1 286 ? 161.658 160.193 180.417 1.00 39.51  ? 286 GLN C CD  1 
ATOM 1617 O OE1 . GLN A 1 286 ? 162.149 160.472 179.325 1.00 39.51  ? 286 GLN C OE1 1 
ATOM 1618 N NE2 . GLN A 1 286 ? 162.051 160.768 181.546 1.00 39.51  ? 286 GLN C NE2 1 
ATOM 1619 N N   . SER A 1 287 ? 160.257 154.805 179.920 1.00 36.66  ? 287 SER C N   1 
ATOM 1620 C CA  . SER A 1 287 ? 160.508 153.397 179.648 1.00 36.66  ? 287 SER C CA  1 
ATOM 1621 C C   . SER A 1 287 ? 160.803 153.220 178.165 1.00 36.66  ? 287 SER C C   1 
ATOM 1622 O O   . SER A 1 287 ? 160.664 154.148 177.365 1.00 36.66  ? 287 SER C O   1 
ATOM 1623 C CB  . SER A 1 287 ? 159.324 152.536 180.084 1.00 36.66  ? 287 SER C CB  1 
ATOM 1624 O OG  . SER A 1 287 ? 159.660 151.161 180.068 1.00 36.66  ? 287 SER C OG  1 
ATOM 1625 N N   . ALA A 1 288 ? 161.217 152.007 177.812 1.00 38.84  ? 288 ALA C N   1 
ATOM 1626 C CA  . ALA A 1 288 ? 161.515 151.633 176.437 1.00 38.84  ? 288 ALA C CA  1 
ATOM 1627 C C   . ALA A 1 288 ? 161.632 150.119 176.380 1.00 38.84  ? 288 ALA C C   1 
ATOM 1628 O O   . ALA A 1 288 ? 161.993 149.473 177.366 1.00 38.84  ? 288 ALA C O   1 
ATOM 1629 C CB  . ALA A 1 288 ? 162.800 152.298 175.937 1.00 38.84  ? 288 ALA C CB  1 
ATOM 1630 N N   . THR A 1 289 ? 161.315 149.554 175.218 1.00 44.00  ? 289 THR C N   1 
ATOM 1631 C CA  . THR A 1 289 ? 161.337 148.106 175.073 1.00 44.00  ? 289 THR C CA  1 
ATOM 1632 C C   . THR A 1 289 ? 161.612 147.733 173.625 1.00 44.00  ? 289 THR C C   1 
ATOM 1633 O O   . THR A 1 289 ? 161.023 148.307 172.705 1.00 44.00  ? 289 THR C O   1 
ATOM 1634 C CB  . THR A 1 289 ? 160.015 147.481 175.525 1.00 44.00  ? 289 THR C CB  1 
ATOM 1635 O OG1 . THR A 1 289 ? 159.685 147.957 176.833 1.00 44.00  ? 289 THR C OG1 1 
ATOM 1636 C CG2 . THR A 1 289 ? 160.138 145.975 175.578 1.00 44.00  ? 289 THR C CG2 1 
ATOM 1637 N N   . VAL A 1 290 ? 162.508 146.766 173.432 1.00 45.09  ? 290 VAL C N   1 
ATOM 1638 C CA  . VAL A 1 290 ? 162.834 146.235 172.113 1.00 45.09  ? 290 VAL C CA  1 
ATOM 1639 C C   . VAL A 1 290 ? 162.786 144.717 172.180 1.00 45.09  ? 290 VAL C C   1 
ATOM 1640 O O   . VAL A 1 290 ? 163.388 144.113 173.074 1.00 45.09  ? 290 VAL C O   1 
ATOM 1641 C CB  . VAL A 1 290 ? 164.214 146.694 171.616 1.00 45.09  ? 290 VAL C CB  1 
ATOM 1642 C CG1 . VAL A 1 290 ? 164.520 146.060 170.276 1.00 45.09  ? 290 VAL C CG1 1 
ATOM 1643 C CG2 . VAL A 1 290 ? 164.247 148.194 171.482 1.00 45.09  ? 290 VAL C CG2 1 
ATOM 1644 N N   . LEU A 1 291 ? 162.072 144.103 171.244 1.00 45.36  ? 291 LEU C N   1 
ATOM 1645 C CA  . LEU A 1 291 ? 162.098 142.658 171.097 1.00 45.36  ? 291 LEU C CA  1 
ATOM 1646 C C   . LEU A 1 291 ? 163.290 142.237 170.248 1.00 45.36  ? 291 LEU C C   1 
ATOM 1647 O O   . LEU A 1 291 ? 163.704 142.945 169.326 1.00 45.36  ? 291 LEU C O   1 
ATOM 1648 C CB  . LEU A 1 291 ? 160.807 142.159 170.454 1.00 45.36  ? 291 LEU C CB  1 
ATOM 1649 C CG  . LEU A 1 291 ? 160.570 140.649 170.473 1.00 45.36  ? 291 LEU C CG  1 
ATOM 1650 C CD1 . LEU A 1 291 ? 160.747 140.087 171.871 1.00 45.36  ? 291 LEU C CD1 1 
ATOM 1651 C CD2 . LEU A 1 291 ? 159.200 140.312 169.914 1.00 45.36  ? 291 LEU C CD2 1 
ATOM 1652 N N   . LEU A 1 292 ? 163.846 141.075 170.571 1.00 54.84  ? 292 LEU C N   1 
ATOM 1653 C CA  . LEU A 1 292 ? 164.927 140.474 169.799 1.00 54.84  ? 292 LEU C CA  1 
ATOM 1654 C C   . LEU A 1 292 ? 164.427 139.141 169.264 1.00 54.84  ? 292 LEU C C   1 
ATOM 1655 O O   . LEU A 1 292 ? 164.591 138.104 169.915 1.00 54.84  ? 292 LEU C O   1 
ATOM 1656 C CB  . LEU A 1 292 ? 166.181 140.299 170.651 1.00 54.84  ? 292 LEU C CB  1 
ATOM 1657 C CG  . LEU A 1 292 ? 167.273 141.341 170.420 1.00 54.84  ? 292 LEU C CG  1 
ATOM 1658 C CD1 . LEU A 1 292 ? 166.815 142.701 170.903 1.00 54.84  ? 292 LEU C CD1 1 
ATOM 1659 C CD2 . LEU A 1 292 ? 168.551 140.933 171.125 1.00 54.84  ? 292 LEU C CD2 1 
ATOM 1660 N N   . ASN A 1 293 ? 163.823 139.170 168.079 1.00 66.70  ? 293 ASN C N   1 
ATOM 1661 C CA  . ASN A 1 293 ? 163.175 137.992 167.520 1.00 66.70  ? 293 ASN C CA  1 
ATOM 1662 C C   . ASN A 1 293 ? 164.198 137.041 166.915 1.00 66.70  ? 293 ASN C C   1 
ATOM 1663 O O   . ASN A 1 293 ? 165.403 137.194 167.133 1.00 66.70  ? 293 ASN C O   1 
ATOM 1664 C CB  . ASN A 1 293 ? 162.143 138.400 166.469 1.00 66.70  ? 293 ASN C CB  1 
ATOM 1665 C CG  . ASN A 1 293 ? 160.917 137.513 166.486 1.00 66.70  ? 293 ASN C CG  1 
ATOM 1666 O OD1 . ASN A 1 293 ? 160.979 136.359 166.907 1.00 66.70  ? 293 ASN C OD1 1 
ATOM 1667 N ND2 . ASN A 1 293 ? 159.792 138.049 166.028 1.00 66.70  ? 293 ASN C ND2 1 
ATOM 1668 N N   . GLU A 1 294 ? 163.727 136.061 166.154 1.00 79.87  ? 294 GLU C N   1 
ATOM 1669 C CA  . GLU A 1 294 ? 164.594 135.064 165.525 1.00 79.87  ? 294 GLU C CA  1 
ATOM 1670 C C   . GLU A 1 294 ? 165.298 135.632 164.300 1.00 79.87  ? 294 GLU C C   1 
ATOM 1671 O O   . GLU A 1 294 ? 165.973 134.917 163.561 1.00 79.87  ? 294 GLU C O   1 
ATOM 1672 C CB  . GLU A 1 294 ? 163.784 133.826 165.163 1.00 79.87  ? 294 GLU C CB  1 
ATOM 1673 C CG  . GLU A 1 294 ? 162.528 134.131 164.365 1.00 79.87  ? 294 GLU C CG  1 
ATOM 1674 C CD  . GLU A 1 294 ? 162.775 134.142 162.872 1.00 79.87  ? 294 GLU C CD  1 
ATOM 1675 O OE1 . GLU A 1 294 ? 163.800 133.581 162.434 1.00 79.87  ? 294 GLU C OE1 1 
ATOM 1676 O OE2 . GLU A 1 294 ? 161.947 134.718 162.135 1.00 79.87  ? 294 GLU C OE2 1 
ATOM 1677 N N   . ASP A 1 295 ? 165.156 136.938 164.075 1.00 83.92  ? 295 ASP C N   1 
ATOM 1678 C CA  . ASP A 1 295 ? 165.832 137.608 162.976 1.00 83.92  ? 295 ASP C CA  1 
ATOM 1679 C C   . ASP A 1 295 ? 167.221 138.107 163.336 1.00 83.92  ? 295 ASP C C   1 
ATOM 1680 O O   . ASP A 1 295 ? 167.929 138.589 162.446 1.00 83.92  ? 295 ASP C O   1 
ATOM 1681 C CB  . ASP A 1 295 ? 164.996 138.794 162.470 1.00 83.92  ? 295 ASP C CB  1 
ATOM 1682 C CG  . ASP A 1 295 ? 165.023 139.971 163.424 1.00 83.92  ? 295 ASP C CG  1 
ATOM 1683 O OD1 . ASP A 1 295 ? 164.576 139.813 164.580 1.00 83.92  ? 295 ASP C OD1 1 
ATOM 1684 O OD2 . ASP A 1 295 ? 165.492 141.056 163.019 1.00 83.92  ? 295 ASP C OD2 1 
ATOM 1685 N N   . VAL A 1 296 ? 167.631 138.013 164.596 1.00 83.11  ? 296 VAL C N   1 
ATOM 1686 C CA  . VAL A 1 296 ? 168.957 138.431 165.031 1.00 83.11  ? 296 VAL C CA  1 
ATOM 1687 C C   . VAL A 1 296 ? 169.756 137.181 165.371 1.00 83.11  ? 296 VAL C C   1 
ATOM 1688 O O   . VAL A 1 296 ? 169.360 136.399 166.244 1.00 83.11  ? 296 VAL C O   1 
ATOM 1689 C CB  . VAL A 1 296 ? 168.876 139.384 166.233 1.00 83.11  ? 296 VAL C CB  1 
ATOM 1690 C CG1 . VAL A 1 296 ? 170.220 139.467 166.935 1.00 83.11  ? 296 VAL C CG1 1 
ATOM 1691 C CG2 . VAL A 1 296 ? 168.414 140.760 165.783 1.00 83.11  ? 296 VAL C CG2 1 
ATOM 1692 N N   . SER A 1 297 ? 170.879 136.985 164.678 1.00 86.51  ? 297 SER C N   1 
ATOM 1693 C CA  . SER A 1 297 ? 171.696 135.800 164.890 1.00 86.51  ? 297 SER C CA  1 
ATOM 1694 C C   . SER A 1 297 ? 173.195 136.063 164.864 1.00 86.51  ? 297 SER C C   1 
ATOM 1695 O O   . SER A 1 297 ? 173.964 135.097 164.847 1.00 86.51  ? 297 SER C O   1 
ATOM 1696 C CB  . SER A 1 297 ? 171.357 134.727 163.843 1.00 86.51  ? 297 SER C CB  1 
ATOM 1697 O OG  . SER A 1 297 ? 172.085 133.535 164.083 1.00 86.51  ? 297 SER C OG  1 
ATOM 1698 N N   . ASP A 1 298 ? 173.638 137.315 164.857 1.00 82.55  ? 298 ASP C N   1 
ATOM 1699 C CA  . ASP A 1 298 ? 175.063 137.617 164.825 1.00 82.55  ? 298 ASP C CA  1 
ATOM 1700 C C   . ASP A 1 298 ? 175.293 138.974 165.480 1.00 82.55  ? 298 ASP C C   1 
ATOM 1701 O O   . ASP A 1 298 ? 174.352 139.636 165.927 1.00 82.55  ? 298 ASP C O   1 
ATOM 1702 C CB  . ASP A 1 298 ? 175.598 137.557 163.387 1.00 82.55  ? 298 ASP C CB  1 
ATOM 1703 C CG  . ASP A 1 298 ? 174.619 138.116 162.377 1.00 82.55  ? 298 ASP C CG  1 
ATOM 1704 O OD1 . ASP A 1 298 ? 173.502 138.496 162.783 1.00 82.55  ? 298 ASP C OD1 1 
ATOM 1705 O OD2 . ASP A 1 298 ? 174.965 138.174 161.178 1.00 82.55  ? 298 ASP C OD2 1 
ATOM 1706 N N   . GLU A 1 299 ? 176.563 139.383 165.539 1.00 73.19  ? 299 GLU C N   1 
ATOM 1707 C CA  . GLU A 1 299 ? 176.931 140.604 166.249 1.00 73.19  ? 299 GLU C CA  1 
ATOM 1708 C C   . GLU A 1 299 ? 176.285 141.833 165.623 1.00 73.19  ? 299 GLU C C   1 
ATOM 1709 O O   . GLU A 1 299 ? 175.749 142.692 166.332 1.00 73.19  ? 299 GLU C O   1 
ATOM 1710 C CB  . GLU A 1 299 ? 178.452 140.756 166.265 1.00 73.19  ? 299 GLU C CB  1 
ATOM 1711 C CG  . GLU A 1 299 ? 179.214 139.445 166.373 1.00 73.19  ? 299 GLU C CG  1 
ATOM 1712 C CD  . GLU A 1 299 ? 179.473 139.036 167.808 1.00 73.19  ? 299 GLU C CD  1 
ATOM 1713 O OE1 . GLU A 1 299 ? 180.359 138.186 168.035 1.00 73.19  ? 299 GLU C OE1 1 
ATOM 1714 O OE2 . GLU A 1 299 ? 178.805 139.579 168.711 1.00 73.19  ? 299 GLU C OE2 1 
ATOM 1715 N N   . LYS A 1 300 ? 176.330 141.937 164.293 1.00 71.39  ? 300 LYS C N   1 
ATOM 1716 C CA  . LYS A 1 300 ? 175.834 143.142 163.635 1.00 71.39  ? 300 LYS C CA  1 
ATOM 1717 C C   . LYS A 1 300 ? 174.327 143.294 163.786 1.00 71.39  ? 300 LYS C C   1 
ATOM 1718 O O   . LYS A 1 300 ? 173.838 144.407 164.012 1.00 71.39  ? 300 LYS C O   1 
ATOM 1719 C CB  . LYS A 1 300 ? 176.224 143.136 162.158 1.00 71.39  ? 300 LYS C CB  1 
ATOM 1720 C CG  . LYS A 1 300 ? 176.044 144.480 161.472 1.00 71.39  ? 300 LYS C CG  1 
ATOM 1721 C CD  . LYS A 1 300 ? 177.053 145.497 161.983 1.00 71.39  ? 300 LYS C CD  1 
ATOM 1722 C CE  . LYS A 1 300 ? 178.463 145.161 161.526 1.00 71.39  ? 300 LYS C CE  1 
ATOM 1723 N NZ  . LYS A 1 300 ? 179.492 145.931 162.280 1.00 71.39  ? 300 LYS C NZ  1 
ATOM 1724 N N   . THR A 1 301 ? 173.575 142.200 163.659 1.00 73.84  ? 301 THR C N   1 
ATOM 1725 C CA  . THR A 1 301 ? 172.129 142.278 163.830 1.00 73.84  ? 301 THR C CA  1 
ATOM 1726 C C   . THR A 1 301 ? 171.743 142.659 165.252 1.00 73.84  ? 301 THR C C   1 
ATOM 1727 O O   . THR A 1 301 ? 170.806 143.443 165.444 1.00 73.84  ? 301 THR C O   1 
ATOM 1728 C CB  . THR A 1 301 ? 171.473 140.949 163.457 1.00 73.84  ? 301 THR C CB  1 
ATOM 1729 O OG1 . THR A 1 301 ? 172.249 139.866 163.984 1.00 73.84  ? 301 THR C OG1 1 
ATOM 1730 C CG2 . THR A 1 301 ? 171.375 140.813 161.947 1.00 73.84  ? 301 THR C CG2 1 
ATOM 1731 N N   . ALA A 1 302 ? 172.438 142.115 166.253 1.00 69.51  ? 302 ALA C N   1 
ATOM 1732 C CA  . ALA A 1 302 ? 172.148 142.483 167.633 1.00 69.51  ? 302 ALA C CA  1 
ATOM 1733 C C   . ALA A 1 302 ? 172.414 143.959 167.885 1.00 69.51  ? 302 ALA C C   1 
ATOM 1734 O O   . ALA A 1 302 ? 171.606 144.629 168.537 1.00 69.51  ? 302 ALA C O   1 
ATOM 1735 C CB  . ALA A 1 302 ? 172.967 141.624 168.593 1.00 69.51  ? 302 ALA C CB  1 
ATOM 1736 N N   . GLU A 1 303 ? 173.528 144.485 167.372 1.00 71.73  ? 303 GLU C N   1 
ATOM 1737 C CA  . GLU A 1 303 ? 173.816 145.905 167.526 1.00 71.73  ? 303 GLU C CA  1 
ATOM 1738 C C   . GLU A 1 303 ? 172.802 146.777 166.801 1.00 71.73  ? 303 GLU C C   1 
ATOM 1739 O O   . GLU A 1 303 ? 172.522 147.889 167.258 1.00 71.73  ? 303 GLU C O   1 
ATOM 1740 C CB  . GLU A 1 303 ? 175.226 146.214 167.024 1.00 71.73  ? 303 GLU C CB  1 
ATOM 1741 C CG  . GLU A 1 303 ? 176.306 146.033 168.074 1.00 71.73  ? 303 GLU C CG  1 
ATOM 1742 C CD  . GLU A 1 303 ? 177.538 146.868 167.793 1.00 71.73  ? 303 GLU C CD  1 
ATOM 1743 O OE1 . GLU A 1 303 ? 178.660 146.362 168.000 1.00 71.73  ? 303 GLU C OE1 1 
ATOM 1744 O OE2 . GLU A 1 303 ? 177.385 148.029 167.361 1.00 71.73  ? 303 GLU C OE2 1 
ATOM 1745 N N   . ALA A 1 304 ? 172.247 146.300 165.685 1.00 66.96  ? 304 ALA C N   1 
ATOM 1746 C CA  . ALA A 1 304 ? 171.210 147.062 164.998 1.00 66.96  ? 304 ALA C CA  1 
ATOM 1747 C C   . ALA A 1 304 ? 169.968 147.206 165.865 1.00 66.96  ? 304 ALA C C   1 
ATOM 1748 O O   . ALA A 1 304 ? 169.343 148.272 165.892 1.00 66.96  ? 304 ALA C O   1 
ATOM 1749 C CB  . ALA A 1 304 ? 170.861 146.396 163.668 1.00 66.96  ? 304 ALA C CB  1 
ATOM 1750 N N   . ALA A 1 305 ? 169.594 146.142 166.580 1.00 65.83  ? 305 ALA C N   1 
ATOM 1751 C CA  . ALA A 1 305 ? 168.402 146.197 167.418 1.00 65.83  ? 305 ALA C CA  1 
ATOM 1752 C C   . ALA A 1 305 ? 168.562 147.199 168.554 1.00 65.83  ? 305 ALA C C   1 
ATOM 1753 O O   . ALA A 1 305 ? 167.654 147.995 168.819 1.00 65.83  ? 305 ALA C O   1 
ATOM 1754 C CB  . ALA A 1 305 ? 168.082 144.808 167.968 1.00 65.83  ? 305 ALA C CB  1 
ATOM 1755 N N   . MET A 1 306 ? 169.709 147.185 169.233 1.00 65.18  ? 306 MET C N   1 
ATOM 1756 C CA  . MET A 1 306 ? 169.927 148.112 170.335 1.00 65.18  ? 306 MET C CA  1 
ATOM 1757 C C   . MET A 1 306 ? 170.183 149.536 169.864 1.00 65.18  ? 306 MET C C   1 
ATOM 1758 O O   . MET A 1 306 ? 170.130 150.459 170.683 1.00 65.18  ? 306 MET C O   1 
ATOM 1759 C CB  . MET A 1 306 ? 171.087 147.632 171.207 1.00 65.18  ? 306 MET C CB  1 
ATOM 1760 C CG  . MET A 1 306 ? 171.193 146.122 171.283 1.00 65.18  ? 306 MET C CG  1 
ATOM 1761 S SD  . MET A 1 306 ? 170.228 145.407 172.624 1.00 65.18  ? 306 MET C SD  1 
ATOM 1762 C CE  . MET A 1 306 ? 171.503 145.134 173.846 1.00 65.18  ? 306 MET C CE  1 
ATOM 1763 N N   . GLN A 1 307 ? 170.459 149.737 168.574 1.00 69.00  ? 307 GLN C N   1 
ATOM 1764 C CA  . GLN A 1 307 ? 170.498 151.092 168.037 1.00 69.00  ? 307 GLN C CA  1 
ATOM 1765 C C   . GLN A 1 307 ? 169.105 151.707 168.024 1.00 69.00  ? 307 GLN C C   1 
ATOM 1766 O O   . GLN A 1 307 ? 168.951 152.919 168.215 1.00 69.00  ? 307 GLN C O   1 
ATOM 1767 C CB  . GLN A 1 307 ? 171.102 151.085 166.633 1.00 69.00  ? 307 GLN C CB  1 
ATOM 1768 C CG  . GLN A 1 307 ? 171.083 152.435 165.932 1.00 69.00  ? 307 GLN C CG  1 
ATOM 1769 C CD  . GLN A 1 307 ? 172.146 153.381 166.454 1.00 69.00  ? 307 GLN C CD  1 
ATOM 1770 O OE1 . GLN A 1 307 ? 172.039 153.904 167.563 1.00 69.00  ? 307 GLN C OE1 1 
ATOM 1771 N NE2 . GLN A 1 307 ? 173.181 153.606 165.655 1.00 69.00  ? 307 GLN C NE2 1 
ATOM 1772 N N   . ARG A 1 308 ? 168.078 150.881 167.809 1.00 61.58  ? 308 ARG C N   1 
ATOM 1773 C CA  . ARG A 1 308 ? 166.706 151.370 167.875 1.00 61.58  ? 308 ARG C CA  1 
ATOM 1774 C C   . ARG A 1 308 ? 166.371 151.872 169.273 1.00 61.58  ? 308 ARG C C   1 
ATOM 1775 O O   . ARG A 1 308 ? 165.665 152.875 169.429 1.00 61.58  ? 308 ARG C O   1 
ATOM 1776 C CB  . ARG A 1 308 ? 165.738 150.267 167.449 1.00 61.58  ? 308 ARG C CB  1 
ATOM 1777 C CG  . ARG A 1 308 ? 165.849 149.885 165.983 1.00 61.58  ? 308 ARG C CG  1 
ATOM 1778 C CD  . ARG A 1 308 ? 165.388 148.459 165.741 1.00 61.58  ? 308 ARG C CD  1 
ATOM 1779 N NE  . ARG A 1 308 ? 164.113 148.172 166.386 1.00 61.58  ? 308 ARG C NE  1 
ATOM 1780 C CZ  . ARG A 1 308 ? 163.538 146.978 166.406 1.00 61.58  ? 308 ARG C CZ  1 
ATOM 1781 N NH1 . ARG A 1 308 ? 164.103 145.930 165.830 1.00 61.58  ? 308 ARG C NH1 1 
ATOM 1782 N NH2 . ARG A 1 308 ? 162.369 146.831 167.021 1.00 61.58  ? 308 ARG C NH2 1 
ATOM 1783 N N   . LEU A 1 309 ? 166.867 151.183 170.303 1.00 54.31  ? 309 LEU C N   1 
ATOM 1784 C CA  . LEU A 1 309 ? 166.650 151.636 171.674 1.00 54.31  ? 309 LEU C CA  1 
ATOM 1785 C C   . LEU A 1 309 ? 167.277 153.002 171.913 1.00 54.31  ? 309 LEU C C   1 
ATOM 1786 O O   . LEU A 1 309 ? 166.690 153.851 172.593 1.00 54.31  ? 309 LEU C O   1 
ATOM 1787 C CB  . LEU A 1 309 ? 167.208 150.608 172.656 1.00 54.31  ? 309 LEU C CB  1 
ATOM 1788 C CG  . LEU A 1 309 ? 166.641 150.629 174.074 1.00 54.31  ? 309 LEU C CG  1 
ATOM 1789 C CD1 . LEU A 1 309 ? 165.161 150.351 174.066 1.00 54.31  ? 309 LEU C CD1 1 
ATOM 1790 C CD2 . LEU A 1 309 ? 167.362 149.608 174.933 1.00 54.31  ? 309 LEU C CD2 1 
ATOM 1791 N N   . LYS A 1 310 ? 168.471 153.233 171.365 1.00 58.90  ? 310 LYS C N   1 
ATOM 1792 C CA  . LYS A 1 310 ? 169.123 154.526 171.525 1.00 58.90  ? 310 LYS C CA  1 
ATOM 1793 C C   . LYS A 1 310 ? 168.332 155.656 170.879 1.00 58.90  ? 310 LYS C C   1 
ATOM 1794 O O   . LYS A 1 310 ? 168.394 156.793 171.359 1.00 58.90  ? 310 LYS C O   1 
ATOM 1795 C CB  . LYS A 1 310 ? 170.534 154.475 170.938 1.00 58.90  ? 310 LYS C CB  1 
ATOM 1796 C CG  . LYS A 1 310 ? 171.391 155.684 171.261 1.00 58.90  ? 310 LYS C CG  1 
ATOM 1797 C CD  . LYS A 1 310 ? 172.233 155.444 172.501 1.00 58.90  ? 310 LYS C CD  1 
ATOM 1798 C CE  . LYS A 1 310 ? 172.848 156.736 173.010 1.00 58.90  ? 310 LYS C CE  1 
ATOM 1799 N NZ  . LYS A 1 310 ? 173.545 156.543 174.311 1.00 58.90  ? 310 LYS C NZ  1 
ATOM 1800 N N   . ALA A 1 311 ? 167.582 155.369 169.812 1.00 58.91  ? 311 ALA C N   1 
ATOM 1801 C CA  . ALA A 1 311 ? 166.821 156.409 169.130 1.00 58.91  ? 311 ALA C CA  1 
ATOM 1802 C C   . ALA A 1 311 ? 165.624 156.883 169.941 1.00 58.91  ? 311 ALA C C   1 
ATOM 1803 O O   . ALA A 1 311 ? 165.051 157.930 169.619 1.00 58.91  ? 311 ALA C O   1 
ATOM 1804 C CB  . ALA A 1 311 ? 166.355 155.910 167.763 1.00 58.91  ? 311 ALA C CB  1 
ATOM 1805 N N   . ALA A 1 312 ? 165.234 156.148 170.979 1.00 56.65  ? 312 ALA C N   1 
ATOM 1806 C CA  . ALA A 1 312 ? 164.111 156.541 171.820 1.00 56.65  ? 312 ALA C CA  1 
ATOM 1807 C C   . ALA A 1 312 ? 164.414 157.758 172.683 1.00 56.65  ? 312 ALA C C   1 
ATOM 1808 O O   . ALA A 1 312 ? 163.492 158.298 173.303 1.00 56.65  ? 312 ALA C O   1 
ATOM 1809 C CB  . ALA A 1 312 ? 163.686 155.372 172.710 1.00 56.65  ? 312 ALA C CB  1 
ATOM 1810 N N   . ASN A 1 313 ? 165.670 158.193 172.736 1.00 58.15  ? 313 ASN C N   1 
ATOM 1811 C CA  . ASN A 1 313 ? 166.087 159.359 173.512 1.00 58.15  ? 313 ASN C CA  1 
ATOM 1812 C C   . ASN A 1 313 ? 165.722 159.204 174.986 1.00 58.15  ? 313 ASN C C   1 
ATOM 1813 O O   . ASN A 1 313 ? 165.261 160.138 175.646 1.00 58.15  ? 313 ASN C O   1 
ATOM 1814 C CB  . ASN A 1 313 ? 165.499 160.641 172.931 1.00 58.15  ? 313 ASN C CB  1 
ATOM 1815 C CG  . ASN A 1 313 ? 166.364 161.232 171.839 1.00 58.15  ? 313 ASN C CG  1 
ATOM 1816 O OD1 . ASN A 1 313 ? 167.444 160.721 171.546 1.00 58.15  ? 313 ASN C OD1 1 
ATOM 1817 N ND2 . ASN A 1 313 ? 165.895 162.314 171.230 1.00 58.15  ? 313 ASN C ND2 1 
ATOM 1818 N N   . ILE A 1 314 ? 165.932 157.998 175.502 1.00 46.75  ? 314 ILE C N   1 
ATOM 1819 C CA  . ILE A 1 314 ? 165.795 157.735 176.931 1.00 46.75  ? 314 ILE C CA  1 
ATOM 1820 C C   . ILE A 1 314 ? 167.042 158.276 177.619 1.00 46.75  ? 314 ILE C C   1 
ATOM 1821 O O   . ILE A 1 314 ? 168.163 157.967 177.188 1.00 46.75  ? 314 ILE C O   1 
ATOM 1822 C CB  . ILE A 1 314 ? 165.598 156.239 177.214 1.00 46.75  ? 314 ILE C CB  1 
ATOM 1823 C CG1 . ILE A 1 314 ? 164.175 155.814 176.854 1.00 46.75  ? 314 ILE C CG1 1 
ATOM 1824 C CG2 . ILE A 1 314 ? 165.892 155.930 178.672 1.00 46.75  ? 314 ILE C CG2 1 
ATOM 1825 C CD1 . ILE A 1 314 ? 163.131 156.313 177.821 1.00 46.75  ? 314 ILE C CD1 1 
ATOM 1826 N N   . PRO A 1 315 ? 166.905 159.086 178.674 1.00 53.89  ? 315 PRO C N   1 
ATOM 1827 C CA  . PRO A 1 315 ? 168.089 159.676 179.314 1.00 53.89  ? 315 PRO C CA  1 
ATOM 1828 C C   . PRO A 1 315 ? 169.037 158.630 179.878 1.00 53.89  ? 315 PRO C C   1 
ATOM 1829 O O   . PRO A 1 315 ? 168.664 157.464 180.036 1.00 53.89  ? 315 PRO C O   1 
ATOM 1830 C CB  . PRO A 1 315 ? 167.490 160.554 180.422 1.00 53.89  ? 315 PRO C CB  1 
ATOM 1831 C CG  . PRO A 1 315 ? 166.066 160.766 180.016 1.00 53.89  ? 315 PRO C CG  1 
ATOM 1832 C CD  . PRO A 1 315 ? 165.661 159.501 179.337 1.00 53.89  ? 315 PRO C CD  1 
ATOM 1833 N N   . GLU A 1 316 ? 170.271 159.036 180.170 1.00 58.03  ? 316 GLU C N   1 
ATOM 1834 C CA  . GLU A 1 316 ? 171.307 158.099 180.584 1.00 58.03  ? 316 GLU C CA  1 
ATOM 1835 C C   . GLU A 1 316 ? 171.284 157.844 182.086 1.00 58.03  ? 316 GLU C C   1 
ATOM 1836 O O   . GLU A 1 316 ? 171.238 156.691 182.525 1.00 58.03  ? 316 GLU C O   1 
ATOM 1837 C CB  . GLU A 1 316 ? 172.685 158.621 180.164 1.00 58.03  ? 316 GLU C CB  1 
ATOM 1838 C CG  . GLU A 1 316 ? 172.916 158.727 178.654 1.00 58.03  ? 316 GLU C CG  1 
ATOM 1839 C CD  . GLU A 1 316 ? 172.627 157.447 177.881 1.00 58.03  ? 316 GLU C CD  1 
ATOM 1840 O OE1 . GLU A 1 316 ? 172.492 157.529 176.642 1.00 58.03  ? 316 GLU C OE1 1 
ATOM 1841 O OE2 . GLU A 1 316 ? 172.572 156.357 178.488 1.00 58.03  ? 316 GLU C OE2 1 
ATOM 1842 N N   . HIS A 1 317 ? 171.330 158.912 182.881 1.00 66.30  ? 317 HIS C N   1 
ATOM 1843 C CA  . HIS A 1 317 ? 171.469 158.793 184.328 1.00 66.30  ? 317 HIS C CA  1 
ATOM 1844 C C   . HIS A 1 317 ? 170.205 158.249 184.980 1.00 66.30  ? 317 HIS C C   1 
ATOM 1845 O O   . HIS A 1 317 ? 169.099 158.452 184.472 1.00 66.30  ? 317 HIS C O   1 
ATOM 1846 C CB  . HIS A 1 317 ? 171.822 160.148 184.947 1.00 66.30  ? 317 HIS C CB  1 
ATOM 1847 C CG  . HIS A 1 317 ? 171.038 161.294 184.388 1.00 66.30  ? 317 HIS C CG  1 
ATOM 1848 N ND1 . HIS A 1 317 ? 171.208 161.759 183.101 1.00 66.30  ? 317 HIS C ND1 1 
ATOM 1849 C CD2 . HIS A 1 317 ? 170.074 162.067 184.942 1.00 66.30  ? 317 HIS C CD2 1 
ATOM 1850 C CE1 . HIS A 1 317 ? 170.385 162.770 182.888 1.00 66.30  ? 317 HIS C CE1 1 
ATOM 1851 N NE2 . HIS A 1 317 ? 169.685 162.976 183.989 1.00 66.30  ? 317 HIS C NE2 1 
ATOM 1852 N N   . ASN A 1 318 ? 170.369 157.565 186.114 1.00 58.31  ? 318 ASN C N   1 
ATOM 1853 C CA  . ASN A 1 318 ? 169.262 157.063 186.931 1.00 58.31  ? 318 ASN C CA  1 
ATOM 1854 C C   . ASN A 1 318 ? 168.376 156.079 186.176 1.00 58.31  ? 318 ASN C C   1 
ATOM 1855 O O   . ASN A 1 318 ? 167.170 156.007 186.425 1.00 58.31  ? 318 ASN C O   1 
ATOM 1856 C CB  . ASN A 1 318 ? 168.414 158.212 187.488 1.00 58.31  ? 318 ASN C CB  1 
ATOM 1857 C CG  . ASN A 1 318 ? 169.020 158.835 188.727 1.00 58.31  ? 318 ASN C CG  1 
ATOM 1858 O OD1 . ASN A 1 318 ? 169.771 159.807 188.643 1.00 58.31  ? 318 ASN C OD1 1 
ATOM 1859 N ND2 . ASN A 1 318 ? 168.694 158.280 189.887 1.00 58.31  ? 318 ASN C ND2 1 
ATOM 1860 N N   . THR A 1 319 ? 168.946 155.313 185.252 1.00 47.83  ? 319 THR C N   1 
ATOM 1861 C CA  . THR A 1 319 ? 168.210 154.270 184.553 1.00 47.83  ? 319 THR C CA  1 
ATOM 1862 C C   . THR A 1 319 ? 168.840 152.915 184.830 1.00 47.83  ? 319 THR C C   1 
ATOM 1863 O O   . THR A 1 319 ? 170.060 152.803 184.974 1.00 47.83  ? 319 THR C O   1 
ATOM 1864 C CB  . THR A 1 319 ? 168.179 154.514 183.045 1.00 47.83  ? 319 THR C CB  1 
ATOM 1865 O OG1 . THR A 1 319 ? 169.334 153.921 182.441 1.00 47.83  ? 319 THR C OG1 1 
ATOM 1866 C CG2 . THR A 1 319 ? 168.162 155.991 182.748 1.00 47.83  ? 319 THR C CG2 1 
ATOM 1867 N N   . ILE A 1 320 ? 168.000 151.889 184.906 1.00 35.96  ? 320 ILE C N   1 
ATOM 1868 C CA  . ILE A 1 320 ? 168.457 150.518 185.079 1.00 35.96  ? 320 ILE C CA  1 
ATOM 1869 C C   . ILE A 1 320 ? 167.888 149.700 183.929 1.00 35.96  ? 320 ILE C C   1 
ATOM 1870 O O   . ILE A 1 320 ? 166.752 149.931 183.501 1.00 35.96  ? 320 ILE C O   1 
ATOM 1871 C CB  . ILE A 1 320 ? 168.051 149.934 186.445 1.00 35.96  ? 320 ILE C CB  1 
ATOM 1872 C CG1 . ILE A 1 320 ? 169.027 148.838 186.870 1.00 35.96  ? 320 ILE C CG1 1 
ATOM 1873 C CG2 . ILE A 1 320 ? 166.621 149.424 186.443 1.00 35.96  ? 320 ILE C CG2 1 
ATOM 1874 C CD1 . ILE A 1 320 ? 168.951 148.504 188.338 1.00 35.96  ? 320 ILE C CD1 1 
ATOM 1875 N N   . GLY A 1 321 ? 168.691 148.792 183.389 1.00 38.28  ? 321 GLY C N   1 
ATOM 1876 C CA  . GLY A 1 321 ? 168.296 147.999 182.244 1.00 38.28  ? 321 GLY C CA  1 
ATOM 1877 C C   . GLY A 1 321 ? 167.966 146.578 182.653 1.00 38.28  ? 321 GLY C C   1 
ATOM 1878 O O   . GLY A 1 321 ? 168.482 146.067 183.648 1.00 38.28  ? 321 GLY C O   1 
ATOM 1879 N N   . PHE A 1 322 ? 167.095 145.946 181.879 1.00 28.77  ? 322 PHE C N   1 
ATOM 1880 C CA  . PHE A 1 322 ? 166.714 144.564 182.106 1.00 28.77  ? 322 PHE C CA  1 
ATOM 1881 C C   . PHE A 1 322 ? 166.822 143.772 180.811 1.00 28.77  ? 322 PHE C C   1 
ATOM 1882 O O   . PHE A 1 322 ? 166.620 144.300 179.715 1.00 28.77  ? 322 PHE C O   1 
ATOM 1883 C CB  . PHE A 1 322 ? 165.294 144.462 182.672 1.00 28.77  ? 322 PHE C CB  1 
ATOM 1884 C CG  . PHE A 1 322 ? 165.165 144.962 184.082 1.00 28.77  ? 322 PHE C CG  1 
ATOM 1885 C CD1 . PHE A 1 322 ? 165.514 144.155 185.149 1.00 28.77  ? 322 PHE C CD1 1 
ATOM 1886 C CD2 . PHE A 1 322 ? 164.695 146.235 184.341 1.00 28.77  ? 322 PHE C CD2 1 
ATOM 1887 C CE1 . PHE A 1 322 ? 165.397 144.608 186.446 1.00 28.77  ? 322 PHE C CE1 1 
ATOM 1888 C CE2 . PHE A 1 322 ? 164.576 146.692 185.637 1.00 28.77  ? 322 PHE C CE2 1 
ATOM 1889 C CZ  . PHE A 1 322 ? 164.928 145.878 186.690 1.00 28.77  ? 322 PHE C CZ  1 
ATOM 1890 N N   . MET A 1 323 ? 167.147 142.490 180.952 1.00 47.17  ? 323 MET C N   1 
ATOM 1891 C CA  . MET A 1 323 ? 167.281 141.588 179.813 1.00 47.17  ? 323 MET C CA  1 
ATOM 1892 C C   . MET A 1 323 ? 166.725 140.231 180.213 1.00 47.17  ? 323 MET C C   1 
ATOM 1893 O O   . MET A 1 323 ? 167.367 139.493 180.965 1.00 47.17  ? 323 MET C O   1 
ATOM 1894 C CB  . MET A 1 323 ? 168.737 141.464 179.368 1.00 47.17  ? 323 MET C CB  1 
ATOM 1895 C CG  . MET A 1 323 ? 168.952 140.432 178.278 1.00 47.17  ? 323 MET C CG  1 
ATOM 1896 S SD  . MET A 1 323 ? 170.492 139.517 178.460 1.00 47.17  ? 323 MET C SD  1 
ATOM 1897 C CE  . MET A 1 323 ? 171.684 140.833 178.249 1.00 47.17  ? 323 MET C CE  1 
ATOM 1898 N N   . PHE A 1 324 ? 165.537 139.905 179.718 1.00 44.02  ? 324 PHE C N   1 
ATOM 1899 C CA  . PHE A 1 324 ? 164.921 138.604 179.935 1.00 44.02  ? 324 PHE C CA  1 
ATOM 1900 C C   . PHE A 1 324 ? 165.004 137.795 178.650 1.00 44.02  ? 324 PHE C C   1 
ATOM 1901 O O   . PHE A 1 324 ? 164.490 138.221 177.611 1.00 44.02  ? 324 PHE C O   1 
ATOM 1902 C CB  . PHE A 1 324 ? 163.469 138.758 180.385 1.00 44.02  ? 324 PHE C CB  1 
ATOM 1903 C CG  . PHE A 1 324 ? 163.246 139.910 181.319 1.00 44.02  ? 324 PHE C CG  1 
ATOM 1904 C CD1 . PHE A 1 324 ? 163.770 139.891 182.598 1.00 44.02  ? 324 PHE C CD1 1 
ATOM 1905 C CD2 . PHE A 1 324 ? 162.516 141.012 180.921 1.00 44.02  ? 324 PHE C CD2 1 
ATOM 1906 C CE1 . PHE A 1 324 ? 163.567 140.943 183.463 1.00 44.02  ? 324 PHE C CE1 1 
ATOM 1907 C CE2 . PHE A 1 324 ? 162.315 142.068 181.781 1.00 44.02  ? 324 PHE C CE2 1 
ATOM 1908 C CZ  . PHE A 1 324 ? 162.839 142.033 183.054 1.00 44.02  ? 324 PHE C CZ  1 
ATOM 1909 N N   . ALA A 1 325 ? 165.647 136.632 178.724 1.00 47.37  ? 325 ALA C N   1 
ATOM 1910 C CA  . ALA A 1 325 ? 165.885 135.826 177.535 1.00 47.37  ? 325 ALA C CA  1 
ATOM 1911 C C   . ALA A 1 325 ? 165.451 134.383 177.747 1.00 47.37  ? 325 ALA C C   1 
ATOM 1912 O O   . ALA A 1 325 ? 164.902 134.041 178.799 1.00 47.37  ? 325 ALA C O   1 
ATOM 1913 C CB  . ALA A 1 325 ? 167.361 135.881 177.143 1.00 47.37  ? 325 ALA C CB  1 
ATOM 1914 N N   . CYS A 1 326 ? 165.691 133.533 176.756 1.00 56.73  ? 326 CYS C N   1 
ATOM 1915 C CA  . CYS A 1 326 ? 165.330 132.127 176.816 1.00 56.73  ? 326 CYS C CA  1 
ATOM 1916 C C   . CYS A 1 326 ? 166.573 131.274 177.019 1.00 56.73  ? 326 CYS C C   1 
ATOM 1917 O O   . CYS A 1 326 ? 167.670 131.618 176.571 1.00 56.73  ? 326 CYS C O   1 
ATOM 1918 C CB  . CYS A 1 326 ? 164.604 131.689 175.541 1.00 56.73  ? 326 CYS C CB  1 
ATOM 1919 S SG  . CYS A 1 326 ? 163.593 130.204 175.732 1.00 56.73  ? 326 CYS C SG  1 
ATOM 1920 N N   . VAL A 1 327 ? 166.384 130.143 177.703 1.00 57.22  ? 327 VAL C N   1 
ATOM 1921 C CA  . VAL A 1 327 ? 167.492 129.227 177.939 1.00 57.22  ? 327 VAL C CA  1 
ATOM 1922 C C   . VAL A 1 327 ? 168.035 128.664 176.632 1.00 57.22  ? 327 VAL C C   1 
ATOM 1923 O O   . VAL A 1 327 ? 169.159 128.151 176.601 1.00 57.22  ? 327 VAL C O   1 
ATOM 1924 C CB  . VAL A 1 327 ? 167.059 128.098 178.894 1.00 57.22  ? 327 VAL C CB  1 
ATOM 1925 C CG1 . VAL A 1 327 ? 166.363 126.982 178.131 1.00 57.22  ? 327 VAL C CG1 1 
ATOM 1926 C CG2 . VAL A 1 327 ? 168.255 127.563 179.664 1.00 57.22  ? 327 VAL C CG2 1 
ATOM 1927 N N   . GLY A 1 328 ? 167.266 128.751 175.547 1.00 61.84  ? 328 GLY C N   1 
ATOM 1928 C CA  . GLY A 1 328 ? 167.744 128.344 174.240 1.00 61.84  ? 328 GLY C CA  1 
ATOM 1929 C C   . GLY A 1 328 ? 168.585 129.383 173.530 1.00 61.84  ? 328 GLY C C   1 
ATOM 1930 O O   . GLY A 1 328 ? 169.062 129.114 172.423 1.00 61.84  ? 328 GLY C O   1 
ATOM 1931 N N   . ARG A 1 329 ? 168.771 130.553 174.131 1.00 67.84  ? 329 ARG C N   1 
ATOM 1932 C CA  . ARG A 1 329 ? 169.606 131.603 173.572 1.00 67.84  ? 329 ARG C CA  1 
ATOM 1933 C C   . ARG A 1 329 ? 170.850 131.801 174.428 1.00 67.84  ? 329 ARG C C   1 
ATOM 1934 O O   . ARG A 1 329 ? 170.805 131.699 175.656 1.00 67.84  ? 329 ARG C O   1 
ATOM 1935 C CB  . ARG A 1 329 ? 168.836 132.919 173.464 1.00 67.84  ? 329 ARG C CB  1 
ATOM 1936 C CG  . ARG A 1 329 ? 169.633 134.041 172.825 1.00 67.84  ? 329 ARG C CG  1 
ATOM 1937 C CD  . ARG A 1 329 ? 168.735 135.158 172.341 1.00 67.84  ? 329 ARG C CD  1 
ATOM 1938 N NE  . ARG A 1 329 ? 167.538 134.644 171.692 1.00 67.84  ? 329 ARG C NE  1 
ATOM 1939 C CZ  . ARG A 1 329 ? 167.220 134.873 170.426 1.00 67.84  ? 329 ARG C CZ  1 
ATOM 1940 N NH1 . ARG A 1 329 ? 167.997 135.601 169.641 1.00 67.84  ? 329 ARG C NH1 1 
ATOM 1941 N NH2 . ARG A 1 329 ? 166.098 134.356 169.934 1.00 67.84  ? 329 ARG C NH2 1 
ATOM 1942 N N   . GLY A 1 330 ? 171.967 132.080 173.763 1.00 84.25  ? 330 GLY C N   1 
ATOM 1943 C CA  . GLY A 1 330 ? 173.220 132.277 174.458 1.00 84.25  ? 330 GLY C CA  1 
ATOM 1944 C C   . GLY A 1 330 ? 174.386 131.623 173.751 1.00 84.25  ? 330 GLY C C   1 
ATOM 1945 O O   . GLY A 1 330 ? 174.679 131.937 172.593 1.00 84.25  ? 330 GLY C O   1 
ATOM 1946 N N   . PHE A 1 331 ? 175.065 130.713 174.451 1.00 92.91  ? 331 PHE C N   1 
ATOM 1947 C CA  . PHE A 1 331 ? 176.192 130.003 173.856 1.00 92.91  ? 331 PHE C CA  1 
ATOM 1948 C C   . PHE A 1 331 ? 175.742 129.194 172.645 1.00 92.91  ? 331 PHE C C   1 
ATOM 1949 O O   . PHE A 1 331 ? 176.407 129.196 171.603 1.00 92.91  ? 331 PHE C O   1 
ATOM 1950 C CB  . PHE A 1 331 ? 176.831 129.098 174.913 1.00 92.91  ? 331 PHE C CB  1 
ATOM 1951 C CG  . PHE A 1 331 ? 178.190 128.562 174.543 1.00 92.91  ? 331 PHE C CG  1 
ATOM 1952 C CD1 . PHE A 1 331 ? 178.826 128.943 173.373 1.00 92.91  ? 331 PHE C CD1 1 
ATOM 1953 C CD2 . PHE A 1 331 ? 178.855 127.706 175.406 1.00 92.91  ? 331 PHE C CD2 1 
ATOM 1954 C CE1 . PHE A 1 331 ? 180.078 128.451 173.056 1.00 92.91  ? 331 PHE C CE1 1 
ATOM 1955 C CE2 . PHE A 1 331 ? 180.105 127.211 175.093 1.00 92.91  ? 331 PHE C CE2 1 
ATOM 1956 C CZ  . PHE A 1 331 ? 180.718 127.585 173.917 1.00 92.91  ? 331 PHE C CZ  1 
ATOM 1957 N N   . GLN A 1 332 ? 174.601 128.512 172.758 1.00 90.40  ? 332 GLN C N   1 
ATOM 1958 C CA  . GLN A 1 332 ? 174.159 127.619 171.692 1.00 90.40  ? 332 GLN C CA  1 
ATOM 1959 C C   . GLN A 1 332 ? 173.656 128.388 170.474 1.00 90.40  ? 332 GLN C C   1 
ATOM 1960 O O   . GLN A 1 332 ? 174.014 128.068 169.334 1.00 90.40  ? 332 GLN C O   1 
ATOM 1961 C CB  . GLN A 1 332 ? 173.071 126.680 172.217 1.00 90.40  ? 332 GLN C CB  1 
ATOM 1962 C CG  . GLN A 1 332 ? 173.087 125.290 171.598 1.00 90.40  ? 332 GLN C CG  1 
ATOM 1963 C CD  . GLN A 1 332 ? 174.372 124.531 171.875 1.00 90.40  ? 332 GLN C CD  1 
ATOM 1964 O OE1 . GLN A 1 332 ? 175.083 124.818 172.839 1.00 90.40  ? 332 GLN C OE1 1 
ATOM 1965 N NE2 . GLN A 1 332 ? 174.677 123.557 171.027 1.00 90.40  ? 332 GLN C NE2 1 
ATOM 1966 N N   . TYR A 1 333 ? 172.827 129.409 170.692 1.00 82.90  ? 333 TYR C N   1 
ATOM 1967 C CA  . TYR A 1 333 ? 172.092 130.008 169.583 1.00 82.90  ? 333 TYR C CA  1 
ATOM 1968 C C   . TYR A 1 333 ? 173.009 130.839 168.694 1.00 82.90  ? 333 TYR C C   1 
ATOM 1969 O O   . TYR A 1 333 ? 173.188 130.514 167.516 1.00 82.90  ? 333 TYR C O   1 
ATOM 1970 C CB  . TYR A 1 333 ? 170.930 130.856 170.105 1.00 82.90  ? 333 TYR C CB  1 
ATOM 1971 C CG  . TYR A 1 333 ? 169.929 131.238 169.038 1.00 82.90  ? 333 TYR C CG  1 
ATOM 1972 C CD1 . TYR A 1 333 ? 169.390 130.279 168.193 1.00 82.90  ? 333 TYR C CD1 1 
ATOM 1973 C CD2 . TYR A 1 333 ? 169.521 132.552 168.878 1.00 82.90  ? 333 TYR C CD2 1 
ATOM 1974 C CE1 . TYR A 1 333 ? 168.475 130.620 167.217 1.00 82.90  ? 333 TYR C CE1 1 
ATOM 1975 C CE2 . TYR A 1 333 ? 168.606 132.903 167.905 1.00 82.90  ? 333 TYR C CE2 1 
ATOM 1976 C CZ  . TYR A 1 333 ? 168.087 131.934 167.077 1.00 82.90  ? 333 TYR C CZ  1 
ATOM 1977 O OH  . TYR A 1 333 ? 167.174 132.277 166.106 1.00 82.90  ? 333 TYR C OH  1 
ATOM 1978 N N   . TYR A 1 334 ? 173.598 131.904 169.234 1.00 87.92  ? 334 TYR C N   1 
ATOM 1979 C CA  . TYR A 1 334 ? 174.647 132.603 168.501 1.00 87.92  ? 334 TYR C CA  1 
ATOM 1980 C C   . TYR A 1 334 ? 175.932 131.789 168.554 1.00 87.92  ? 334 TYR C C   1 
ATOM 1981 O O   . TYR A 1 334 ? 176.339 131.321 169.622 1.00 87.92  ? 334 TYR C O   1 
ATOM 1982 C CB  . TYR A 1 334 ? 174.869 134.027 169.028 1.00 87.92  ? 334 TYR C CB  1 
ATOM 1983 C CG  . TYR A 1 334 ? 173.615 134.830 169.328 1.00 87.92  ? 334 TYR C CG  1 
ATOM 1984 C CD1 . TYR A 1 334 ? 172.404 134.541 168.711 1.00 87.92  ? 334 TYR C CD1 1 
ATOM 1985 C CD2 . TYR A 1 334 ? 173.667 135.939 170.154 1.00 87.92  ? 334 TYR C CD2 1 
ATOM 1986 C CE1 . TYR A 1 334 ? 171.273 135.294 168.966 1.00 87.92  ? 334 TYR C CE1 1 
ATOM 1987 C CE2 . TYR A 1 334 ? 172.541 136.696 170.419 1.00 87.92  ? 334 TYR C CE2 1 
ATOM 1988 C CZ  . TYR A 1 334 ? 171.346 136.370 169.819 1.00 87.92  ? 334 TYR C CZ  1 
ATOM 1989 O OH  . TYR A 1 334 ? 170.219 137.118 170.069 1.00 87.92  ? 334 TYR C OH  1 
ATOM 1990 N N   . ARG A 1 335 ? 176.567 131.613 167.396 1.00 94.71  ? 335 ARG C N   1 
ATOM 1991 C CA  . ARG A 1 335 ? 177.617 130.619 167.218 1.00 94.71  ? 335 ARG C CA  1 
ATOM 1992 C C   . ARG A 1 335 ? 178.818 130.838 168.131 1.00 94.71  ? 335 ARG C C   1 
ATOM 1993 O O   . ARG A 1 335 ? 179.597 131.773 167.926 1.00 94.71  ? 335 ARG C O   1 
ATOM 1994 C CB  . ARG A 1 335 ? 178.078 130.613 165.759 1.00 94.71  ? 335 ARG C CB  1 
ATOM 1995 C CG  . ARG A 1 335 ? 177.028 130.149 164.756 1.00 94.71  ? 335 ARG C CG  1 
ATOM 1996 C CD  . ARG A 1 335 ? 176.469 128.726 164.938 1.00 94.71  ? 335 ARG C CD  1 
ATOM 1997 N NE  . ARG A 1 335 ? 177.483 127.686 165.097 1.00 94.71  ? 335 ARG C NE  1 
ATOM 1998 C CZ  . ARG A 1 335 ? 177.987 127.256 166.247 1.00 94.71  ? 335 ARG C CZ  1 
ATOM 1999 N NH1 . ARG A 1 335 ? 177.478 127.623 167.410 1.00 94.71  ? 335 ARG C NH1 1 
ATOM 2000 N NH2 . ARG A 1 335 ? 178.994 126.388 166.226 1.00 94.71  ? 335 ARG C NH2 1 
ATOM 2001 N N   . ALA A 1 336 ? 178.977 129.965 169.127 1.00 96.49  ? 336 ALA C N   1 
ATOM 2002 C CA  . ALA A 1 336 ? 180.199 129.848 169.918 1.00 96.49  ? 336 ALA C CA  1 
ATOM 2003 C C   . ALA A 1 336 ? 180.636 131.132 170.618 1.00 96.49  ? 336 ALA C C   1 
ATOM 2004 O O   . ALA A 1 336 ? 181.817 131.279 170.949 1.00 96.49  ? 336 ALA C O   1 
ATOM 2005 C CB  . ALA A 1 336 ? 181.341 129.342 169.033 1.00 96.49  ? 336 ALA C CB  1 
ATOM 2006 N N   . LYS A 1 337 ? 179.714 132.056 170.864 1.00 91.85  ? 337 LYS C N   1 
ATOM 2007 C CA  . LYS A 1 337 ? 180.025 133.276 171.596 1.00 91.85  ? 337 LYS C CA  1 
ATOM 2008 C C   . LYS A 1 337 ? 179.113 133.436 172.809 1.00 91.85  ? 337 LYS C C   1 
ATOM 2009 O O   . LYS A 1 337 ? 178.055 132.811 172.917 1.00 91.85  ? 337 LYS C O   1 
ATOM 2010 C CB  . LYS A 1 337 ? 179.912 134.509 170.692 1.00 91.85  ? 337 LYS C CB  1 
ATOM 2011 C CG  . LYS A 1 337 ? 180.476 134.343 169.294 1.00 91.85  ? 337 LYS C CG  1 
ATOM 2012 C CD  . LYS A 1 337 ? 181.957 134.014 169.329 1.00 91.85  ? 337 LYS C CD  1 
ATOM 2013 C CE  . LYS A 1 337 ? 182.586 134.171 167.956 1.00 91.85  ? 337 LYS C CE  1 
ATOM 2014 N NZ  . LYS A 1 337 ? 181.737 133.561 166.897 1.00 91.85  ? 337 LYS C NZ  1 
ATOM 2015 N N   . GLY A 1 338 ? 179.546 134.295 173.730 1.00 79.18  ? 338 GLY C N   1 
ATOM 2016 C CA  . GLY A 1 338 ? 178.759 134.647 174.896 1.00 79.18  ? 338 GLY C CA  1 
ATOM 2017 C C   . GLY A 1 338 ? 178.953 136.101 175.273 1.00 79.18  ? 338 GLY C C   1 
ATOM 2018 O O   . GLY A 1 338 ? 179.837 136.764 174.724 1.00 79.18  ? 338 GLY C O   1 
ATOM 2019 N N   . ASN A 1 339 ? 178.144 136.606 176.208 1.00 74.10  ? 339 ASN C N   1 
ATOM 2020 C CA  . ASN A 1 339 ? 178.174 138.014 176.596 1.00 74.10  ? 339 ASN C CA  1 
ATOM 2021 C C   . ASN A 1 339 ? 178.060 138.914 175.375 1.00 74.10  ? 339 ASN C C   1 
ATOM 2022 O O   . ASN A 1 339 ? 178.744 139.937 175.279 1.00 74.10  ? 339 ASN C O   1 
ATOM 2023 C CB  . ASN A 1 339 ? 179.444 138.337 177.388 1.00 74.10  ? 339 ASN C CB  1 
ATOM 2024 C CG  . ASN A 1 339 ? 179.147 138.998 178.721 1.00 74.10  ? 339 ASN C CG  1 
ATOM 2025 O OD1 . ASN A 1 339 ? 178.020 138.958 179.212 1.00 74.10  ? 339 ASN C OD1 1 
ATOM 2026 N ND2 . ASN A 1 339 ? 180.168 139.602 179.319 1.00 74.10  ? 339 ASN C ND2 1 
ATOM 2027 N N   . VAL A 1 340 ? 177.192 138.535 174.441 1.00 76.92  ? 340 VAL C N   1 
ATOM 2028 C CA  . VAL A 1 340 ? 177.031 139.244 173.178 1.00 76.92  ? 340 VAL C CA  1 
ATOM 2029 C C   . VAL A 1 340 ? 175.935 140.301 173.273 1.00 76.92  ? 340 VAL C C   1 
ATOM 2030 O O   . VAL A 1 340 ? 176.113 141.429 172.800 1.00 76.92  ? 340 VAL C O   1 
ATOM 2031 C CB  . VAL A 1 340 ? 176.770 138.242 172.039 1.00 76.92  ? 340 VAL C CB  1 
ATOM 2032 C CG1 . VAL A 1 340 ? 175.604 137.362 172.383 1.00 76.92  ? 340 VAL C CG1 1 
ATOM 2033 C CG2 . VAL A 1 340 ? 176.483 138.982 170.751 1.00 76.92  ? 340 VAL C CG2 1 
ATOM 2034 N N   . GLU A 1 341 ? 174.795 139.952 173.873 1.00 75.42  ? 341 GLU C N   1 
ATOM 2035 C CA  . GLU A 1 341 ? 173.786 140.965 174.164 1.00 75.42  ? 341 GLU C CA  1 
ATOM 2036 C C   . GLU A 1 341 ? 174.324 141.980 175.162 1.00 75.42  ? 341 GLU C C   1 
ATOM 2037 O O   . GLU A 1 341 ? 174.107 143.189 175.023 1.00 75.42  ? 341 GLU C O   1 
ATOM 2038 C CB  . GLU A 1 341 ? 172.507 140.319 174.701 1.00 75.42  ? 341 GLU C CB  1 
ATOM 2039 C CG  . GLU A 1 341 ? 171.496 139.923 173.640 1.00 75.42  ? 341 GLU C CG  1 
ATOM 2040 C CD  . GLU A 1 341 ? 171.592 138.466 173.247 1.00 75.42  ? 341 GLU C CD  1 
ATOM 2041 O OE1 . GLU A 1 341 ? 170.553 137.884 172.871 1.00 75.42  ? 341 GLU C OE1 1 
ATOM 2042 O OE2 . GLU A 1 341 ? 172.696 137.896 173.330 1.00 75.42  ? 341 GLU C OE2 1 
ATOM 2043 N N   . ALA A 1 342 ? 175.030 141.496 176.184 1.00 69.06  ? 342 ALA C N   1 
ATOM 2044 C CA  . ALA A 1 342 ? 175.546 142.383 177.219 1.00 69.06  ? 342 ALA C CA  1 
ATOM 2045 C C   . ALA A 1 342 ? 176.561 143.369 176.656 1.00 69.06  ? 342 ALA C C   1 
ATOM 2046 O O   . ALA A 1 342 ? 176.531 144.560 176.988 1.00 69.06  ? 342 ALA C O   1 
ATOM 2047 C CB  . ALA A 1 342 ? 176.164 141.557 178.345 1.00 69.06  ? 342 ALA C CB  1 
ATOM 2048 N N   . ASP A 1 343 ? 177.470 142.893 175.802 1.00 73.63  ? 343 ASP C N   1 
ATOM 2049 C CA  . ASP A 1 343 ? 178.470 143.779 175.218 1.00 73.63  ? 343 ASP C CA  1 
ATOM 2050 C C   . ASP A 1 343 ? 177.852 144.826 174.302 1.00 73.63  ? 343 ASP C C   1 
ATOM 2051 O O   . ASP A 1 343 ? 178.299 145.977 174.310 1.00 73.63  ? 343 ASP C O   1 
ATOM 2052 C CB  . ASP A 1 343 ? 179.512 142.973 174.447 1.00 73.63  ? 343 ASP C CB  1 
ATOM 2053 C CG  . ASP A 1 343 ? 180.821 143.717 174.293 1.00 73.63  ? 343 ASP C CG  1 
ATOM 2054 O OD1 . ASP A 1 343 ? 181.130 144.557 175.163 1.00 73.63  ? 343 ASP C OD1 1 
ATOM 2055 O OD2 . ASP A 1 343 ? 181.537 143.467 173.301 1.00 73.63  ? 343 ASP C OD2 1 
ATOM 2056 N N   . ALA A 1 344 ? 176.841 144.456 173.518 1.00 71.83  ? 344 ALA C N   1 
ATOM 2057 C CA  . ALA A 1 344 ? 176.150 145.400 172.654 1.00 71.83  ? 344 ALA C CA  1 
ATOM 2058 C C   . ALA A 1 344 ? 175.356 146.440 173.430 1.00 71.83  ? 344 ALA C C   1 
ATOM 2059 O O   . ALA A 1 344 ? 175.227 147.575 172.957 1.00 71.83  ? 344 ALA C O   1 
ATOM 2060 C CB  . ALA A 1 344 ? 175.213 144.656 171.695 1.00 71.83  ? 344 ALA C CB  1 
ATOM 2061 N N   . PHE A 1 345 ? 174.830 146.083 174.603 1.00 62.15  ? 345 PHE C N   1 
ATOM 2062 C CA  . PHE A 1 345 ? 174.114 147.049 175.429 1.00 62.15  ? 345 PHE C CA  1 
ATOM 2063 C C   . PHE A 1 345 ? 175.022 148.206 175.821 1.00 62.15  ? 345 PHE C C   1 
ATOM 2064 O O   . PHE A 1 345 ? 174.642 149.376 175.700 1.00 62.15  ? 345 PHE C O   1 
ATOM 2065 C CB  . PHE A 1 345 ? 173.557 146.351 176.670 1.00 62.15  ? 345 PHE C CB  1 
ATOM 2066 C CG  . PHE A 1 345 ? 172.378 147.046 177.295 1.00 62.15  ? 345 PHE C CG  1 
ATOM 2067 C CD1 . PHE A 1 345 ? 172.046 148.344 176.957 1.00 62.15  ? 345 PHE C CD1 1 
ATOM 2068 C CD2 . PHE A 1 345 ? 171.602 146.392 178.232 1.00 62.15  ? 345 PHE C CD2 1 
ATOM 2069 C CE1 . PHE A 1 345 ? 170.967 148.968 177.543 1.00 62.15  ? 345 PHE C CE1 1 
ATOM 2070 C CE2 . PHE A 1 345 ? 170.525 147.013 178.818 1.00 62.15  ? 345 PHE C CE2 1 
ATOM 2071 C CZ  . PHE A 1 345 ? 170.206 148.302 178.472 1.00 62.15  ? 345 PHE C CZ  1 
ATOM 2072 N N   . ARG A 1 346 ? 176.232 147.903 176.276 1.00 64.35  ? 346 ARG C N   1 
ATOM 2073 C CA  . ARG A 1 346 ? 177.175 148.935 176.674 1.00 64.35  ? 346 ARG C CA  1 
ATOM 2074 C C   . ARG A 1 346 ? 177.997 149.465 175.509 1.00 64.35  ? 346 ARG C C   1 
ATOM 2075 O O   . ARG A 1 346 ? 178.805 150.379 175.702 1.00 64.35  ? 346 ARG C O   1 
ATOM 2076 C CB  . ARG A 1 346 ? 178.091 148.417 177.781 1.00 64.35  ? 346 ARG C CB  1 
ATOM 2077 C CG  . ARG A 1 346 ? 177.331 147.883 178.978 1.00 64.35  ? 346 ARG C CG  1 
ATOM 2078 C CD  . ARG A 1 346 ? 178.158 147.991 180.242 1.00 64.35  ? 346 ARG C CD  1 
ATOM 2079 N NE  . ARG A 1 346 ? 179.072 149.125 180.203 1.00 64.35  ? 346 ARG C NE  1 
ATOM 2080 C CZ  . ARG A 1 346 ? 178.711 150.387 180.390 1.00 64.35  ? 346 ARG C CZ  1 
ATOM 2081 N NH1 . ARG A 1 346 ? 177.458 150.715 180.658 1.00 64.35  ? 346 ARG C NH1 1 
ATOM 2082 N NH2 . ARG A 1 346 ? 179.630 151.343 180.301 1.00 64.35  ? 346 ARG C NH2 1 
ATOM 2083 N N   . LYS A 1 347 ? 177.810 148.919 174.308 1.00 69.68  ? 347 LYS C N   1 
ATOM 2084 C CA  . LYS A 1 347 ? 178.437 149.501 173.128 1.00 69.68  ? 347 LYS C CA  1 
ATOM 2085 C C   . LYS A 1 347 ? 177.775 150.827 172.766 1.00 69.68  ? 347 LYS C C   1 
ATOM 2086 O O   . LYS A 1 347 ? 178.455 151.805 172.439 1.00 69.68  ? 347 LYS C O   1 
ATOM 2087 C CB  . LYS A 1 347 ? 178.367 148.519 171.956 1.00 69.68  ? 347 LYS C CB  1 
ATOM 2088 C CG  . LYS A 1 347 ? 178.687 149.132 170.599 1.00 69.68  ? 347 LYS C CG  1 
ATOM 2089 C CD  . LYS A 1 347 ? 180.085 149.732 170.565 1.00 69.68  ? 347 LYS C CD  1 
ATOM 2090 C CE  . LYS A 1 347 ? 180.475 150.142 169.155 1.00 69.68  ? 347 LYS C CE  1 
ATOM 2091 N NZ  . LYS A 1 347 ? 179.950 149.193 168.136 1.00 69.68  ? 347 LYS C NZ  1 
ATOM 2092 N N   . PHE A 1 348 ? 176.444 150.877 172.832 1.00 67.91  ? 348 PHE C N   1 
ATOM 2093 C CA  . PHE A 1 348 ? 175.707 152.081 172.472 1.00 67.91  ? 348 PHE C CA  1 
ATOM 2094 C C   . PHE A 1 348 ? 175.243 152.880 173.681 1.00 67.91  ? 348 PHE C C   1 
ATOM 2095 O O   . PHE A 1 348 ? 175.095 154.104 173.584 1.00 67.91  ? 348 PHE C O   1 
ATOM 2096 C CB  . PHE A 1 348 ? 174.501 151.717 171.605 1.00 67.91  ? 348 PHE C CB  1 
ATOM 2097 C CG  . PHE A 1 348 ? 174.867 151.315 170.212 1.00 67.91  ? 348 PHE C CG  1 
ATOM 2098 C CD1 . PHE A 1 348 ? 175.890 151.962 169.542 1.00 67.91  ? 348 PHE C CD1 1 
ATOM 2099 C CD2 . PHE A 1 348 ? 174.195 150.292 169.571 1.00 67.91  ? 348 PHE C CD2 1 
ATOM 2100 C CE1 . PHE A 1 348 ? 176.235 151.597 168.258 1.00 67.91  ? 348 PHE C CE1 1 
ATOM 2101 C CE2 . PHE A 1 348 ? 174.537 149.922 168.286 1.00 67.91  ? 348 PHE C CE2 1 
ATOM 2102 C CZ  . PHE A 1 348 ? 175.557 150.576 167.628 1.00 67.91  ? 348 PHE C CZ  1 
ATOM 2103 N N   . PHE A 1 349 ? 175.006 152.221 174.812 1.00 59.72  ? 349 PHE C N   1 
ATOM 2104 C CA  . PHE A 1 349 ? 174.652 152.902 176.052 1.00 59.72  ? 349 PHE C CA  1 
ATOM 2105 C C   . PHE A 1 349 ? 175.877 152.952 176.953 1.00 59.72  ? 349 PHE C C   1 
ATOM 2106 O O   . PHE A 1 349 ? 176.344 151.905 177.426 1.00 59.72  ? 349 PHE C O   1 
ATOM 2107 C CB  . PHE A 1 349 ? 173.489 152.192 176.745 1.00 59.72  ? 349 PHE C CB  1 
ATOM 2108 C CG  . PHE A 1 349 ? 172.174 152.394 176.056 1.00 59.72  ? 349 PHE C CG  1 
ATOM 2109 C CD1 . PHE A 1 349 ? 171.573 153.639 176.045 1.00 59.72  ? 349 PHE C CD1 1 
ATOM 2110 C CD2 . PHE A 1 349 ? 171.561 151.355 175.384 1.00 59.72  ? 349 PHE C CD2 1 
ATOM 2111 C CE1 . PHE A 1 349 ? 170.369 153.834 175.404 1.00 59.72  ? 349 PHE C CE1 1 
ATOM 2112 C CE2 . PHE A 1 349 ? 170.358 151.543 174.741 1.00 59.72  ? 349 PHE C CE2 1 
ATOM 2113 C CZ  . PHE A 1 349 ? 169.761 152.785 174.748 1.00 59.72  ? 349 PHE C CZ  1 
ATOM 2114 N N   . PRO A 1 350 ? 176.425 154.134 177.231 1.00 59.69  ? 350 PRO C N   1 
ATOM 2115 C CA  . PRO A 1 350 ? 177.791 154.193 177.769 1.00 59.69  ? 350 PRO C CA  1 
ATOM 2116 C C   . PRO A 1 350 ? 177.900 153.850 179.242 1.00 59.69  ? 350 PRO C C   1 
ATOM 2117 O O   . PRO A 1 350 ? 178.949 153.351 179.663 1.00 59.69  ? 350 PRO C O   1 
ATOM 2118 C CB  . PRO A 1 350 ? 178.214 155.645 177.499 1.00 59.69  ? 350 PRO C CB  1 
ATOM 2119 C CG  . PRO A 1 350 ? 176.976 156.374 177.013 1.00 59.69  ? 350 PRO C CG  1 
ATOM 2120 C CD  . PRO A 1 350 ? 175.802 155.461 177.133 1.00 59.69  ? 350 PRO C CD  1 
ATOM 2121 N N   . SER A 1 351 ? 176.866 154.108 180.053 1.00 57.17  ? 351 SER C N   1 
ATOM 2122 C CA  . SER A 1 351 ? 177.049 153.931 181.490 1.00 57.17  ? 351 SER C CA  1 
ATOM 2123 C C   . SER A 1 351 ? 175.852 153.317 182.212 1.00 57.17  ? 351 SER C C   1 
ATOM 2124 O O   . SER A 1 351 ? 175.852 153.294 183.448 1.00 57.17  ? 351 SER C O   1 
ATOM 2125 C CB  . SER A 1 351 ? 177.383 155.277 182.145 1.00 57.17  ? 351 SER C CB  1 
ATOM 2126 O OG  . SER A 1 351 ? 176.280 156.164 182.080 1.00 57.17  ? 351 SER C OG  1 
ATOM 2127 N N   . VAL A 1 352 ? 174.843 152.820 181.505 1.00 50.25  ? 352 VAL C N   1 
ATOM 2128 C CA  . VAL A 1 352 ? 173.687 152.232 182.177 1.00 50.25  ? 352 VAL C CA  1 
ATOM 2129 C C   . VAL A 1 352 ? 174.057 150.841 182.676 1.00 50.25  ? 352 VAL C C   1 
ATOM 2130 O O   . VAL A 1 352 ? 174.838 150.134 182.023 1.00 50.25  ? 352 VAL C O   1 
ATOM 2131 C CB  . VAL A 1 352 ? 172.458 152.192 181.256 1.00 50.25  ? 352 VAL C CB  1 
ATOM 2132 C CG1 . VAL A 1 352 ? 172.163 153.580 180.714 1.00 50.25  ? 352 VAL C CG1 1 
ATOM 2133 C CG2 . VAL A 1 352 ? 172.663 151.207 180.122 1.00 50.25  ? 352 VAL C CG2 1 
ATOM 2134 N N   . PRO A 1 353 ? 173.557 150.420 183.833 1.00 45.67  ? 353 PRO C N   1 
ATOM 2135 C CA  . PRO A 1 353 ? 173.818 149.051 184.293 1.00 45.67  ? 353 PRO C CA  1 
ATOM 2136 C C   . PRO A 1 353 ? 172.914 148.044 183.603 1.00 45.67  ? 353 PRO C C   1 
ATOM 2137 O O   . PRO A 1 353 ? 172.123 148.416 182.731 1.00 45.67  ? 353 PRO C O   1 
ATOM 2138 C CB  . PRO A 1 353 ? 173.539 149.133 185.798 1.00 45.67  ? 353 PRO C CB  1 
ATOM 2139 C CG  . PRO A 1 353 ? 172.538 150.227 185.915 1.00 45.67  ? 353 PRO C CG  1 
ATOM 2140 C CD  . PRO A 1 353 ? 172.911 151.238 184.872 1.00 45.67  ? 353 PRO C CD  1 
ATOM 2141 N N   . LEU A 1 354 ? 173.015 146.772 183.978 1.00 47.85  ? 354 LEU C N   1 
ATOM 2142 C CA  . LEU A 1 354 ? 172.216 145.730 183.342 1.00 47.85  ? 354 LEU C CA  1 
ATOM 2143 C C   . LEU A 1 354 ? 171.953 144.625 184.353 1.00 47.85  ? 354 LEU C C   1 
ATOM 2144 O O   . LEU A 1 354 ? 172.877 144.196 185.050 1.00 47.85  ? 354 LEU C O   1 
ATOM 2145 C CB  . LEU A 1 354 ? 172.932 145.189 182.098 1.00 47.85  ? 354 LEU C CB  1 
ATOM 2146 C CG  . LEU A 1 354 ? 172.526 143.888 181.401 1.00 47.85  ? 354 LEU C CG  1 
ATOM 2147 C CD1 . LEU A 1 354 ? 173.041 143.904 179.983 1.00 47.85  ? 354 LEU C CD1 1 
ATOM 2148 C CD2 . LEU A 1 354 ? 173.099 142.686 182.109 1.00 47.85  ? 354 LEU C CD2 1 
ATOM 2149 N N   . PHE A 1 355 ? 170.701 144.181 184.442 1.00 48.92  ? 355 PHE C N   1 
ATOM 2150 C CA  . PHE A 1 355 ? 170.313 143.067 185.296 1.00 48.92  ? 355 PHE C CA  1 
ATOM 2151 C C   . PHE A 1 355 ? 169.163 142.304 184.658 1.00 48.92  ? 355 PHE C C   1 
ATOM 2152 O O   . PHE A 1 355 ? 168.165 142.901 184.250 1.00 48.92  ? 355 PHE C O   1 
ATOM 2153 C CB  . PHE A 1 355 ? 169.901 143.548 186.689 1.00 48.92  ? 355 PHE C CB  1 
ATOM 2154 C CG  . PHE A 1 355 ? 170.958 144.340 187.391 1.00 48.92  ? 355 PHE C CG  1 
ATOM 2155 C CD1 . PHE A 1 355 ? 171.943 143.701 188.122 1.00 48.92  ? 355 PHE C CD1 1 
ATOM 2156 C CD2 . PHE A 1 355 ? 170.981 145.720 187.307 1.00 48.92  ? 355 PHE C CD2 1 
ATOM 2157 C CE1 . PHE A 1 355 ? 172.924 144.421 188.765 1.00 48.92  ? 355 PHE C CE1 1 
ATOM 2158 C CE2 . PHE A 1 355 ? 171.958 146.446 187.949 1.00 48.92  ? 355 PHE C CE2 1 
ATOM 2159 C CZ  . PHE A 1 355 ? 172.933 145.794 188.678 1.00 48.92  ? 355 PHE C CZ  1 
ATOM 2160 N N   . GLY A 1 356 ? 169.295 140.982 184.584 1.00 44.65  ? 356 GLY C N   1 
ATOM 2161 C CA  . GLY A 1 356 ? 168.243 140.176 183.992 1.00 44.65  ? 356 GLY C CA  1 
ATOM 2162 C C   . GLY A 1 356 ? 168.509 138.705 184.203 1.00 44.65  ? 356 GLY C C   1 
ATOM 2163 O O   . GLY A 1 356 ? 169.596 138.301 184.621 1.00 44.65  ? 356 GLY C O   1 
ATOM 2164 N N   . PHE A 1 357 ? 167.497 137.898 183.898 1.00 49.54  ? 357 PHE C N   1 
ATOM 2165 C CA  . PHE A 1 357 ? 167.560 136.465 184.136 1.00 49.54  ? 357 PHE C CA  1 
ATOM 2166 C C   . PHE A 1 357 ? 167.365 135.703 182.836 1.00 49.54  ? 357 PHE C C   1 
ATOM 2167 O O   . PHE A 1 357 ? 166.964 136.276 181.819 1.00 49.54  ? 357 PHE C O   1 
ATOM 2168 C CB  . PHE A 1 357 ? 166.502 136.011 185.145 1.00 49.54  ? 357 PHE C CB  1 
ATOM 2169 C CG  . PHE A 1 357 ? 165.099 136.029 184.610 1.00 49.54  ? 357 PHE C CG  1 
ATOM 2170 C CD1 . PHE A 1 357 ? 164.317 137.163 184.703 1.00 49.54  ? 357 PHE C CD1 1 
ATOM 2171 C CD2 . PHE A 1 357 ? 164.556 134.896 184.027 1.00 49.54  ? 357 PHE C CD2 1 
ATOM 2172 C CE1 . PHE A 1 357 ? 163.023 137.168 184.214 1.00 49.54  ? 357 PHE C CE1 1 
ATOM 2173 C CE2 . PHE A 1 357 ? 163.270 134.899 183.534 1.00 49.54  ? 357 PHE C CE2 1 
ATOM 2174 C CZ  . PHE A 1 357 ? 162.502 136.036 183.628 1.00 49.54  ? 357 PHE C CZ  1 
ATOM 2175 N N   . PHE A 1 358 ? 167.648 134.406 182.886 1.00 54.14  ? 358 PHE C N   1 
ATOM 2176 C CA  . PHE A 1 358 ? 167.350 133.471 181.811 1.00 54.14  ? 358 PHE C CA  1 
ATOM 2177 C C   . PHE A 1 358 ? 166.185 132.594 182.244 1.00 54.14  ? 358 PHE C C   1 
ATOM 2178 O O   . PHE A 1 358 ? 166.210 132.027 183.340 1.00 54.14  ? 358 PHE C O   1 
ATOM 2179 C CB  . PHE A 1 358 ? 168.566 132.605 181.484 1.00 54.14  ? 358 PHE C CB  1 
ATOM 2180 C CG  . PHE A 1 358 ? 169.429 133.161 180.398 1.00 54.14  ? 358 PHE C CG  1 
ATOM 2181 C CD1 . PHE A 1 358 ? 169.120 132.935 179.073 1.00 54.14  ? 358 PHE C CD1 1 
ATOM 2182 C CD2 . PHE A 1 358 ? 170.553 133.903 180.700 1.00 54.14  ? 358 PHE C CD2 1 
ATOM 2183 C CE1 . PHE A 1 358 ? 169.910 133.442 178.072 1.00 54.14  ? 358 PHE C CE1 1 
ATOM 2184 C CE2 . PHE A 1 358 ? 171.347 134.409 179.699 1.00 54.14  ? 358 PHE C CE2 1 
ATOM 2185 C CZ  . PHE A 1 358 ? 171.023 134.178 178.385 1.00 54.14  ? 358 PHE C CZ  1 
ATOM 2186 N N   . GLY A 1 359 ? 165.174 132.482 181.394 1.00 55.70  ? 359 GLY C N   1 
ATOM 2187 C CA  . GLY A 1 359 ? 163.985 131.759 181.789 1.00 55.70  ? 359 GLY C CA  1 
ATOM 2188 C C   . GLY A 1 359 ? 163.388 130.989 180.635 1.00 55.70  ? 359 GLY C C   1 
ATOM 2189 O O   . GLY A 1 359 ? 163.889 131.024 179.511 1.00 55.70  ? 359 GLY C O   1 
ATOM 2190 N N   . ASN A 1 360 ? 162.295 130.286 180.939 1.00 61.31  ? 360 ASN C N   1 
ATOM 2191 C CA  . ASN A 1 360 ? 161.589 129.457 179.970 1.00 61.31  ? 360 ASN C CA  1 
ATOM 2192 C C   . ASN A 1 360 ? 160.401 130.170 179.341 1.00 61.31  ? 360 ASN C C   1 
ATOM 2193 O O   . ASN A 1 360 ? 159.513 129.513 178.783 1.00 61.31  ? 360 ASN C O   1 
ATOM 2194 C CB  . ASN A 1 360 ? 161.130 128.156 180.630 1.00 61.31  ? 360 ASN C CB  1 
ATOM 2195 C CG  . ASN A 1 360 ? 162.191 127.551 181.518 1.00 61.31  ? 360 ASN C CG  1 
ATOM 2196 O OD1 . ASN A 1 360 ? 162.549 128.116 182.550 1.00 61.31  ? 360 ASN C OD1 1 
ATOM 2197 N ND2 . ASN A 1 360 ? 162.701 126.391 181.123 1.00 61.31  ? 360 ASN C ND2 1 
ATOM 2198 N N   . GLY A 1 361 ? 160.357 131.496 179.414 1.00 57.41  ? 361 GLY C N   1 
ATOM 2199 C CA  . GLY A 1 361 ? 159.231 132.235 178.881 1.00 57.41  ? 361 GLY C CA  1 
ATOM 2200 C C   . GLY A 1 361 ? 159.540 133.699 178.664 1.00 57.41  ? 361 GLY C C   1 
ATOM 2201 O O   . GLY A 1 361 ? 160.451 134.247 179.289 1.00 57.41  ? 361 GLY C O   1 
ATOM 2202 N N   . GLU A 1 362 ? 158.784 134.347 177.780 1.00 59.06  ? 362 GLU C N   1 
ATOM 2203 C CA  . GLU A 1 362 ? 159.057 135.720 177.392 1.00 59.06  ? 362 GLU C CA  1 
ATOM 2204 C C   . GLU A 1 362 ? 157.773 136.534 177.402 1.00 59.06  ? 362 GLU C C   1 
ATOM 2205 O O   . GLU A 1 362 ? 156.714 136.058 176.985 1.00 59.06  ? 362 GLU C O   1 
ATOM 2206 C CB  . GLU A 1 362 ? 159.702 135.784 176.004 1.00 59.06  ? 362 GLU C CB  1 
ATOM 2207 C CG  . GLU A 1 362 ? 160.737 134.707 175.751 1.00 59.06  ? 362 GLU C CG  1 
ATOM 2208 C CD  . GLU A 1 362 ? 161.918 134.793 176.697 1.00 59.06  ? 362 GLU C CD  1 
ATOM 2209 O OE1 . GLU A 1 362 ? 162.641 133.788 176.826 1.00 59.06  ? 362 GLU C OE1 1 
ATOM 2210 O OE2 . GLU A 1 362 ? 162.143 135.868 177.293 1.00 59.06  ? 362 GLU C OE2 1 
ATOM 2211 N N   . ILE A 1 363 ? 157.881 137.769 177.887 1.00 55.10  ? 363 ILE C N   1 
ATOM 2212 C CA  . ILE A 1 363 ? 156.786 138.733 177.872 1.00 55.10  ? 363 ILE C CA  1 
ATOM 2213 C C   . ILE A 1 363 ? 157.344 140.066 177.396 1.00 55.10  ? 363 ILE C C   1 
ATOM 2214 O O   . ILE A 1 363 ? 158.407 140.496 177.855 1.00 55.10  ? 363 ILE C O   1 
ATOM 2215 C CB  . ILE A 1 363 ? 156.132 138.895 179.259 1.00 55.10  ? 363 ILE C CB  1 
ATOM 2216 C CG1 . ILE A 1 363 ? 155.755 137.535 179.852 1.00 55.10  ? 363 ILE C CG1 1 
ATOM 2217 C CG2 . ILE A 1 363 ? 154.913 139.796 179.171 1.00 55.10  ? 363 ILE C CG2 1 
ATOM 2218 C CD1 . ILE A 1 363 ? 154.495 136.939 179.272 1.00 55.10  ? 363 ILE C CD1 1 
ATOM 2219 N N   . GLY A 1 364 ? 156.644 140.713 176.481 1.00 60.17  ? 364 GLY C N   1 
ATOM 2220 C CA  . GLY A 1 364 ? 157.048 142.030 176.025 1.00 60.17  ? 364 GLY C CA  1 
ATOM 2221 C C   . GLY A 1 364 ? 156.591 142.285 174.605 1.00 60.17  ? 364 GLY C C   1 
ATOM 2222 O O   . GLY A 1 364 ? 156.063 141.411 173.921 1.00 60.17  ? 364 GLY C O   1 
ATOM 2223 N N   . CYS A 1 365 ? 156.808 143.522 174.169 1.00 64.47  ? 365 CYS C N   1 
ATOM 2224 C CA  . CYS A 1 365 ? 156.453 143.957 172.824 1.00 64.47  ? 365 CYS C CA  1 
ATOM 2225 C C   . CYS A 1 365 ? 157.398 145.084 172.424 1.00 64.47  ? 365 CYS C C   1 
ATOM 2226 O O   . CYS A 1 365 ? 158.443 145.290 173.047 1.00 64.47  ? 365 CYS C O   1 
ATOM 2227 C CB  . CYS A 1 365 ? 154.984 144.389 172.768 1.00 64.47  ? 365 CYS C CB  1 
ATOM 2228 S SG  . CYS A 1 365 ? 154.468 145.436 174.149 1.00 64.47  ? 365 CYS C SG  1 
ATOM 2229 N N   . ASP A 1 366 ? 157.037 145.810 171.371 1.00 67.89  ? 366 ASP C N   1 
ATOM 2230 C CA  . ASP A 1 366 ? 157.723 147.036 170.984 1.00 67.89  ? 366 ASP C CA  1 
ATOM 2231 C C   . ASP A 1 366 ? 156.866 148.222 171.397 1.00 67.89  ? 366 ASP C C   1 
ATOM 2232 O O   . ASP A 1 366 ? 155.763 148.406 170.872 1.00 67.89  ? 366 ASP C O   1 
ATOM 2233 C CB  . ASP A 1 366 ? 157.990 147.076 169.478 1.00 67.89  ? 366 ASP C CB  1 
ATOM 2234 C CG  . ASP A 1 366 ? 158.630 145.805 168.965 1.00 67.89  ? 366 ASP C CG  1 
ATOM 2235 O OD1 . ASP A 1 366 ? 159.869 145.687 169.049 1.00 67.89  ? 366 ASP C OD1 1 
ATOM 2236 O OD2 . ASP A 1 366 ? 157.897 144.927 168.465 1.00 67.89  ? 366 ASP C OD2 1 
ATOM 2237 N N   . ARG A 1 367 ? 157.372 149.024 172.332 1.00 76.28  ? 367 ARG C N   1 
ATOM 2238 C CA  . ARG A 1 367 ? 156.585 150.119 172.885 1.00 76.28  ? 367 ARG C CA  1 
ATOM 2239 C C   . ARG A 1 367 ? 157.458 151.094 173.662 1.00 76.28  ? 367 ARG C C   1 
ATOM 2240 O O   . ARG A 1 367 ? 158.366 150.681 174.388 1.00 76.28  ? 367 ARG C O   1 
ATOM 2241 C CB  . ARG A 1 367 ? 155.482 149.569 173.789 1.00 76.28  ? 367 ARG C CB  1 
ATOM 2242 C CG  . ARG A 1 367 ? 154.490 150.608 174.267 1.00 76.28  ? 367 ARG C CG  1 
ATOM 2243 C CD  . ARG A 1 367 ? 153.423 149.978 175.142 1.00 76.28  ? 367 ARG C CD  1 
ATOM 2244 N NE  . ARG A 1 367 ? 153.239 148.564 174.843 1.00 76.28  ? 367 ARG C NE  1 
ATOM 2245 C CZ  . ARG A 1 367 ? 152.130 147.885 175.102 1.00 76.28  ? 367 ARG C CZ  1 
ATOM 2246 N NH1 . ARG A 1 367 ? 151.080 148.464 175.658 1.00 76.28  ? 367 ARG C NH1 1 
ATOM 2247 N NH2 . ARG A 1 367 ? 152.073 146.594 174.792 1.00 76.28  ? 367 ARG C NH2 1 
ATOM 2248 N N   . ILE A 1 368 ? 157.191 152.388 173.514 1.00 50.63  ? 368 ILE C N   1 
ATOM 2249 C CA  . ILE A 1 368 ? 157.889 153.437 174.248 1.00 50.63  ? 368 ILE C CA  1 
ATOM 2250 C C   . ILE A 1 368 ? 156.828 154.297 174.916 1.00 50.63  ? 368 ILE C C   1 
ATOM 2251 O O   . ILE A 1 368 ? 155.914 154.794 174.246 1.00 50.63  ? 368 ILE C O   1 
ATOM 2252 C CB  . ILE A 1 368 ? 158.783 154.289 173.340 1.00 50.63  ? 368 ILE C CB  1 
ATOM 2253 C CG1 . ILE A 1 368 ? 159.578 153.410 172.378 1.00 50.63  ? 368 ILE C CG1 1 
ATOM 2254 C CG2 . ILE A 1 368 ? 159.718 155.142 174.173 1.00 50.63  ? 368 ILE C CG2 1 
ATOM 2255 C CD1 . ILE A 1 368 ? 160.720 152.678 173.029 1.00 50.63  ? 368 ILE C CD1 1 
ATOM 2256 N N   . VAL A 1 369 ? 156.941 154.477 176.228 1.00 46.64  ? 369 VAL C N   1 
ATOM 2257 C CA  . VAL A 1 369 ? 156.062 155.362 176.981 1.00 46.64  ? 369 VAL C CA  1 
ATOM 2258 C C   . VAL A 1 369 ? 156.920 156.340 177.765 1.00 46.64  ? 369 VAL C C   1 
ATOM 2259 O O   . VAL A 1 369 ? 157.809 155.932 178.520 1.00 46.64  ? 369 VAL C O   1 
ATOM 2260 C CB  . VAL A 1 369 ? 155.129 154.581 177.919 1.00 46.64  ? 369 VAL C CB  1 
ATOM 2261 C CG1 . VAL A 1 369 ? 154.376 155.534 178.829 1.00 46.64  ? 369 VAL C CG1 1 
ATOM 2262 C CG2 . VAL A 1 369 ? 154.164 153.736 177.115 1.00 46.64  ? 369 VAL C CG2 1 
ATOM 2263 N N   . THR A 1 370 ? 156.647 157.630 177.589 1.00 41.65  ? 370 THR C N   1 
ATOM 2264 C CA  . THR A 1 370 ? 157.367 158.682 178.292 1.00 41.65  ? 370 THR C CA  1 
ATOM 2265 C C   . THR A 1 370 ? 156.363 159.676 178.854 1.00 41.65  ? 370 THR C C   1 
ATOM 2266 O O   . THR A 1 370 ? 155.165 159.387 178.913 1.00 41.65  ? 370 THR C O   1 
ATOM 2267 C CB  . THR A 1 370 ? 158.357 159.405 177.374 1.00 41.65  ? 370 THR C CB  1 
ATOM 2268 O OG1 . THR A 1 370 ? 157.649 160.333 176.543 1.00 41.65  ? 370 THR C OG1 1 
ATOM 2269 C CG2 . THR A 1 370 ? 159.116 158.423 176.496 1.00 41.65  ? 370 THR C CG2 1 
ATOM 2270 N N   . GLY A 1 371 ? 156.841 160.839 179.282 1.00 50.64  ? 371 GLY C N   1 
ATOM 2271 C CA  . GLY A 1 371 ? 155.959 161.864 179.797 1.00 50.64  ? 371 GLY C CA  1 
ATOM 2272 C C   . GLY A 1 371 ? 154.969 162.382 178.773 1.00 50.64  ? 371 GLY C C   1 
ATOM 2273 O O   . GLY A 1 371 ? 153.906 162.892 179.138 1.00 50.64  ? 371 GLY C O   1 
ATOM 2274 N N   . ASN A 1 372 ? 155.302 162.266 177.488 1.00 48.27  ? 372 ASN C N   1 
ATOM 2275 C CA  . ASN A 1 372 ? 154.427 162.794 176.450 1.00 48.27  ? 372 ASN C CA  1 
ATOM 2276 C C   . ASN A 1 372 ? 153.855 161.716 175.536 1.00 48.27  ? 372 ASN C C   1 
ATOM 2277 O O   . ASN A 1 372 ? 152.633 161.591 175.412 1.00 48.27  ? 372 ASN C O   1 
ATOM 2278 C CB  . ASN A 1 372 ? 155.172 163.834 175.613 1.00 48.27  ? 372 ASN C CB  1 
ATOM 2279 C CG  . ASN A 1 372 ? 156.079 164.710 176.447 1.00 48.27  ? 372 ASN C CG  1 
ATOM 2280 O OD1 . ASN A 1 372 ? 155.782 165.007 177.604 1.00 48.27  ? 372 ASN C OD1 1 
ATOM 2281 N ND2 . ASN A 1 372 ? 157.192 165.137 175.862 1.00 48.27  ? 372 ASN C ND2 1 
ATOM 2282 N N   . PHE A 1 373 ? 154.716 160.925 174.901 1.00 60.32  ? 373 PHE C N   1 
ATOM 2283 C CA  . PHE A 1 373 ? 154.262 160.114 173.779 1.00 60.32  ? 373 PHE C CA  1 
ATOM 2284 C C   . PHE A 1 373 ? 154.160 158.643 174.155 1.00 60.32  ? 373 PHE C C   1 
ATOM 2285 O O   . PHE A 1 373 ? 154.849 158.161 175.057 1.00 60.32  ? 373 PHE C O   1 
ATOM 2286 C CB  . PHE A 1 373 ? 155.199 160.309 172.581 1.00 60.32  ? 373 PHE C CB  1 
ATOM 2287 C CG  . PHE A 1 373 ? 156.509 159.578 172.685 1.00 60.32  ? 373 PHE C CG  1 
ATOM 2288 C CD1 . PHE A 1 373 ? 156.603 158.229 172.379 1.00 60.32  ? 373 PHE C CD1 1 
ATOM 2289 C CD2 . PHE A 1 373 ? 157.666 160.265 172.991 1.00 60.32  ? 373 PHE C CD2 1 
ATOM 2290 C CE1 . PHE A 1 373 ? 157.814 157.572 172.454 1.00 60.32  ? 373 PHE C CE1 1 
ATOM 2291 C CE2 . PHE A 1 373 ? 158.878 159.616 173.068 1.00 60.32  ? 373 PHE C CE2 1 
ATOM 2292 C CZ  . PHE A 1 373 ? 158.953 158.267 172.795 1.00 60.32  ? 373 PHE C CZ  1 
ATOM 2293 N N   . ILE A 1 374 ? 153.277 157.934 173.457 1.00 49.36  ? 374 ILE C N   1 
ATOM 2294 C CA  . ILE A 1 374 ? 153.113 156.492 173.585 1.00 49.36  ? 374 ILE C CA  1 
ATOM 2295 C C   . ILE A 1 374 ? 153.125 155.906 172.181 1.00 49.36  ? 374 ILE C C   1 
ATOM 2296 O O   . ILE A 1 374 ? 152.466 156.439 171.280 1.00 49.36  ? 374 ILE C O   1 
ATOM 2297 C CB  . ILE A 1 374 ? 151.814 156.121 174.316 1.00 49.36  ? 374 ILE C CB  1 
ATOM 2298 C CG1 . ILE A 1 374 ? 151.687 156.911 175.618 1.00 49.36  ? 374 ILE C CG1 1 
ATOM 2299 C CG2 . ILE A 1 374 ? 151.779 154.641 174.603 1.00 49.36  ? 374 ILE C CG2 1 
ATOM 2300 C CD1 . ILE A 1 374 ? 150.312 157.499 175.844 1.00 49.36  ? 374 ILE C CD1 1 
ATOM 2301 N N   . LEU A 1 375 ? 153.863 154.813 171.992 1.00 76.28  ? 375 LEU C N   1 
ATOM 2302 C CA  . LEU A 1 375 ? 154.070 154.254 170.660 1.00 76.28  ? 375 LEU C CA  1 
ATOM 2303 C C   . LEU A 1 375 ? 153.582 152.814 170.562 1.00 76.28  ? 375 LEU C C   1 
ATOM 2304 O O   . LEU A 1 375 ? 154.309 151.943 170.077 1.00 76.28  ? 375 LEU C O   1 
ATOM 2305 C CB  . LEU A 1 375 ? 155.548 154.333 170.277 1.00 76.28  ? 375 LEU C CB  1 
ATOM 2306 C CG  . LEU A 1 375 ? 155.872 154.369 168.784 1.00 76.28  ? 375 LEU C CG  1 
ATOM 2307 C CD1 . LEU A 1 375 ? 155.688 155.765 168.230 1.00 76.28  ? 375 LEU C CD1 1 
ATOM 2308 C CD2 . LEU A 1 375 ? 157.281 153.883 168.535 1.00 76.28  ? 375 LEU C CD2 1 
ATOM 2309 N N   . ARG A 1 376 ? 152.362 152.553 171.028 1.00 64.28  ? 376 ARG C N   1 
ATOM 2310 C CA  . ARG A 1 376 ? 151.827 151.199 171.063 1.00 64.28  ? 376 ARG C CA  1 
ATOM 2311 C C   . ARG A 1 376 ? 151.836 150.551 169.680 1.00 64.28  ? 376 ARG C C   1 
ATOM 2312 O O   . ARG A 1 376 ? 151.935 151.216 168.646 1.00 64.28  ? 376 ARG C O   1 
ATOM 2313 C CB  . ARG A 1 376 ? 150.396 151.199 171.598 1.00 64.28  ? 376 ARG C CB  1 
ATOM 2314 C CG  . ARG A 1 376 ? 150.148 152.160 172.735 1.00 64.28  ? 376 ARG C CG  1 
ATOM 2315 C CD  . ARG A 1 376 ? 148.690 152.142 173.156 1.00 64.28  ? 376 ARG C CD  1 
ATOM 2316 N NE  . ARG A 1 376 ? 147.803 151.893 172.026 1.00 64.28  ? 376 ARG C NE  1 
ATOM 2317 C CZ  . ARG A 1 376 ? 147.262 152.843 171.276 1.00 64.28  ? 376 ARG C CZ  1 
ATOM 2318 N NH1 . ARG A 1 376 ? 147.492 154.124 171.509 1.00 64.28  ? 376 ARG C NH1 1 
ATOM 2319 N NH2 . ARG A 1 376 ? 146.468 152.498 170.266 1.00 64.28  ? 376 ARG C NH2 1 
ATOM 2320 N N   . LYS A 1 377 ? 151.725 149.227 169.680 1.00 78.56  ? 377 LYS C N   1 
ATOM 2321 C CA  . LYS A 1 377 ? 151.563 148.426 168.470 1.00 78.56  ? 377 LYS C CA  1 
ATOM 2322 C C   . LYS A 1 377 ? 150.071 148.133 168.343 1.00 78.56  ? 377 LYS C C   1 
ATOM 2323 O O   . LYS A 1 377 ? 149.435 147.698 169.307 1.00 78.56  ? 377 LYS C O   1 
ATOM 2324 C CB  . LYS A 1 377 ? 152.392 147.148 168.549 1.00 78.56  ? 377 LYS C CB  1 
ATOM 2325 C CG  . LYS A 1 377 ? 151.981 146.060 167.573 1.00 78.56  ? 377 LYS C CG  1 
ATOM 2326 C CD  . LYS A 1 377 ? 152.972 145.956 166.425 1.00 78.56  ? 377 LYS C CD  1 
ATOM 2327 C CE  . LYS A 1 377 ? 152.670 144.759 165.537 1.00 78.56  ? 377 LYS C CE  1 
ATOM 2328 N NZ  . LYS A 1 377 ? 153.704 144.574 164.480 1.00 78.56  ? 377 LYS C NZ  1 
ATOM 2329 N N   . CYS A 1 378 ? 149.511 148.387 167.159 1.00 88.38  ? 378 CYS C N   1 
ATOM 2330 C CA  . CYS A 1 378 ? 148.066 148.310 166.963 1.00 88.38  ? 378 CYS C CA  1 
ATOM 2331 C C   . CYS A 1 378 ? 147.516 146.917 167.242 1.00 88.38  ? 378 CYS C C   1 
ATOM 2332 O O   . CYS A 1 378 ? 146.358 146.787 167.652 1.00 88.38  ? 378 CYS C O   1 
ATOM 2333 C CB  . CYS A 1 378 ? 147.695 148.753 165.548 1.00 88.38  ? 378 CYS C CB  1 
ATOM 2334 S SG  . CYS A 1 378 ? 147.628 150.547 165.352 1.00 88.38  ? 378 CYS C SG  1 
ATOM 2335 N N   . ASN A 1 379 ? 148.319 145.886 166.968 1.00 100.61 ? 379 ASN C N   1 
ATOM 2336 C CA  . ASN A 1 379 ? 148.128 144.508 167.446 1.00 100.61 ? 379 ASN C CA  1 
ATOM 2337 C C   . ASN A 1 379 ? 146.654 144.096 167.508 1.00 100.61 ? 379 ASN C C   1 
ATOM 2338 O O   . ASN A 1 379 ? 146.158 143.560 168.501 1.00 100.61 ? 379 ASN C O   1 
ATOM 2339 C CB  . ASN A 1 379 ? 148.848 144.309 168.790 1.00 100.61 ? 379 ASN C CB  1 
ATOM 2340 C CG  . ASN A 1 379 ? 148.183 145.035 169.970 1.00 100.61 ? 379 ASN C CG  1 
ATOM 2341 O OD1 . ASN A 1 379 ? 147.112 145.625 169.858 1.00 100.61 ? 379 ASN C OD1 1 
ATOM 2342 N ND2 . ASN A 1 379 ? 148.847 144.989 171.118 1.00 100.61 ? 379 ASN C ND2 1 
ATOM 2343 N N   . GLU A 1 380 ? 145.968 144.309 166.392 1.00 113.45 ? 380 GLU C N   1 
ATOM 2344 C CA  . GLU A 1 380 ? 144.514 144.256 166.351 1.00 113.45 ? 380 GLU C CA  1 
ATOM 2345 C C   . GLU A 1 380 ? 143.932 142.847 166.450 1.00 113.45 ? 380 GLU C C   1 
ATOM 2346 O O   . GLU A 1 380 ? 142.718 142.709 166.274 1.00 113.45 ? 380 GLU C O   1 
ATOM 2347 C CB  . GLU A 1 380 ? 144.003 144.915 165.067 1.00 113.45 ? 380 GLU C CB  1 
ATOM 2348 C CG  . GLU A 1 380 ? 144.923 145.975 164.489 1.00 113.45 ? 380 GLU C CG  1 
ATOM 2349 C CD  . GLU A 1 380 ? 144.293 146.715 163.325 1.00 113.45 ? 380 GLU C CD  1 
ATOM 2350 O OE1 . GLU A 1 380 ? 144.272 146.159 162.207 1.00 113.45 ? 380 GLU C OE1 1 
ATOM 2351 O OE2 . GLU A 1 380 ? 143.815 147.851 163.527 1.00 113.45 ? 380 GLU C OE2 1 
ATOM 2352 N N   . VAL A 1 381 ? 144.714 141.799 166.717 1.00 118.95 ? 381 VAL C N   1 
ATOM 2353 C CA  . VAL A 1 381 ? 144.096 140.478 166.644 1.00 118.95 ? 381 VAL C CA  1 
ATOM 2354 C C   . VAL A 1 381 ? 143.375 140.158 167.948 1.00 118.95 ? 381 VAL C C   1 
ATOM 2355 O O   . VAL A 1 381 ? 142.145 140.268 168.016 1.00 118.95 ? 381 VAL C O   1 
ATOM 2356 C CB  . VAL A 1 381 ? 145.142 139.398 166.318 1.00 118.95 ? 381 VAL C CB  1 
ATOM 2357 C CG1 . VAL A 1 381 ? 144.456 138.092 165.948 1.00 118.95 ? 381 VAL C CG1 1 
ATOM 2358 C CG2 . VAL A 1 381 ? 146.055 139.867 165.196 1.00 118.95 ? 381 VAL C CG2 1 
ATOM 2359 N N   . LYS A 1 382 ? 144.105 139.765 168.995 1.00 116.34 ? 382 LYS C N   1 
ATOM 2360 C CA  . LYS A 1 382 ? 143.597 139.979 170.346 1.00 116.34 ? 382 LYS C CA  1 
ATOM 2361 C C   . LYS A 1 382 ? 144.665 140.532 171.284 1.00 116.34 ? 382 LYS C C   1 
ATOM 2362 O O   . LYS A 1 382 ? 144.586 141.683 171.727 1.00 116.34 ? 382 LYS C O   1 
ATOM 2363 C CB  . LYS A 1 382 ? 143.025 138.670 170.902 1.00 116.34 ? 382 LYS C CB  1 
ATOM 2364 C CG  . LYS A 1 382 ? 142.748 138.653 172.408 1.00 116.34 ? 382 LYS C CG  1 
ATOM 2365 C CD  . LYS A 1 382 ? 141.889 139.824 172.869 1.00 116.34 ? 382 LYS C CD  1 
ATOM 2366 C CE  . LYS A 1 382 ? 141.549 139.698 174.346 1.00 116.34 ? 382 LYS C CE  1 
ATOM 2367 N NZ  . LYS A 1 382 ? 141.578 141.013 175.043 1.00 116.34 ? 382 LYS C NZ  1 
ATOM 2368 N N   . ASP A 1 383 ? 145.664 139.705 171.585 1.00 104.63 ? 383 ASP C N   1 
ATOM 2369 C CA  . ASP A 1 383 ? 146.761 140.047 172.484 1.00 104.63 ? 383 ASP C CA  1 
ATOM 2370 C C   . ASP A 1 383 ? 148.024 139.274 172.099 1.00 104.63 ? 383 ASP C C   1 
ATOM 2371 O O   . ASP A 1 383 ? 148.863 138.942 172.933 1.00 104.63 ? 383 ASP C O   1 
ATOM 2372 C CB  . ASP A 1 383 ? 146.358 139.782 173.933 1.00 104.63 ? 383 ASP C CB  1 
ATOM 2373 C CG  . ASP A 1 383 ? 146.899 140.826 174.886 1.00 104.63 ? 383 ASP C CG  1 
ATOM 2374 O OD1 . ASP A 1 383 ? 146.856 142.025 174.542 1.00 104.63 ? 383 ASP C OD1 1 
ATOM 2375 O OD2 . ASP A 1 383 ? 147.364 140.445 175.980 1.00 104.63 ? 383 ASP C OD2 1 
ATOM 2376 N N   . ASP A 1 384 ? 148.191 138.961 170.816 1.00 102.74 ? 384 ASP C N   1 
ATOM 2377 C CA  . ASP A 1 384 ? 149.213 138.015 170.385 1.00 102.74 ? 384 ASP C CA  1 
ATOM 2378 C C   . ASP A 1 384 ? 150.578 138.669 170.204 1.00 102.74 ? 384 ASP C C   1 
ATOM 2379 O O   . ASP A 1 384 ? 151.417 138.147 169.461 1.00 102.74 ? 384 ASP C O   1 
ATOM 2380 C CB  . ASP A 1 384 ? 148.782 137.323 169.091 1.00 102.74 ? 384 ASP C CB  1 
ATOM 2381 C CG  . ASP A 1 384 ? 148.394 138.306 168.006 1.00 102.74 ? 384 ASP C CG  1 
ATOM 2382 O OD1 . ASP A 1 384 ? 147.708 139.301 168.322 1.00 102.74 ? 384 ASP C OD1 1 
ATOM 2383 O OD2 . ASP A 1 384 ? 148.772 138.083 166.837 1.00 102.74 ? 384 ASP C OD2 1 
ATOM 2384 N N   . ASP A 1 385 ? 150.820 139.793 170.874 1.00 88.82  ? 385 ASP C N   1 
ATOM 2385 C CA  . ASP A 1 385 ? 152.052 140.557 170.731 1.00 88.82  ? 385 ASP C CA  1 
ATOM 2386 C C   . ASP A 1 385 ? 152.880 140.520 172.011 1.00 88.82  ? 385 ASP C C   1 
ATOM 2387 O O   . ASP A 1 385 ? 153.863 141.251 172.143 1.00 88.82  ? 385 ASP C O   1 
ATOM 2388 C CB  . ASP A 1 385 ? 151.730 142.000 170.352 1.00 88.82  ? 385 ASP C CB  1 
ATOM 2389 C CG  . ASP A 1 385 ? 151.018 142.743 171.467 1.00 88.82  ? 385 ASP C CG  1 
ATOM 2390 O OD1 . ASP A 1 385 ? 151.679 143.127 172.453 1.00 88.82  ? 385 ASP C OD1 1 
ATOM 2391 O OD2 . ASP A 1 385 ? 149.802 142.977 171.344 1.00 88.82  ? 385 ASP C OD2 1 
ATOM 2392 N N   . LEU A 1 386 ? 152.486 139.681 172.967 1.00 73.04  ? 386 LEU C N   1 
ATOM 2393 C CA  . LEU A 1 386 ? 153.132 139.670 174.273 1.00 73.04  ? 386 LEU C CA  1 
ATOM 2394 C C   . LEU A 1 386 ? 153.854 138.356 174.535 1.00 73.04  ? 386 LEU C C   1 
ATOM 2395 O O   . LEU A 1 386 ? 155.051 138.348 174.840 1.00 73.04  ? 386 LEU C O   1 
ATOM 2396 C CB  . LEU A 1 386 ? 152.103 139.934 175.373 1.00 73.04  ? 386 LEU C CB  1 
ATOM 2397 C CG  . LEU A 1 386 ? 151.706 141.394 175.587 1.00 73.04  ? 386 LEU C CG  1 
ATOM 2398 C CD1 . LEU A 1 386 ? 151.206 141.607 177.001 1.00 73.04  ? 386 LEU C CD1 1 
ATOM 2399 C CD2 . LEU A 1 386 ? 152.882 142.307 175.302 1.00 73.04  ? 386 LEU C CD2 1 
ATOM 2400 N N   . PHE A 1 387 ? 153.140 137.241 174.410 1.00 71.21  ? 387 PHE C N   1 
ATOM 2401 C CA  . PHE A 1 387 ? 153.718 135.939 174.715 1.00 71.21  ? 387 PHE C CA  1 
ATOM 2402 C C   . PHE A 1 387 ? 154.531 135.396 173.552 1.00 71.21  ? 387 PHE C C   1 
ATOM 2403 O O   . PHE A 1 387 ? 154.015 134.657 172.708 1.00 71.21  ? 387 PHE C O   1 
ATOM 2404 C CB  . PHE A 1 387 ? 152.630 134.940 175.115 1.00 71.21  ? 387 PHE C CB  1 
ATOM 2405 C CG  . PHE A 1 387 ? 151.837 135.357 176.315 1.00 71.21  ? 387 PHE C CG  1 
ATOM 2406 C CD1 . PHE A 1 387 ? 150.945 136.412 176.257 1.00 71.21  ? 387 PHE C CD1 1 
ATOM 2407 C CD2 . PHE A 1 387 ? 151.997 134.688 177.513 1.00 71.21  ? 387 PHE C CD2 1 
ATOM 2408 C CE1 . PHE A 1 387 ? 150.234 136.788 177.370 1.00 71.21  ? 387 PHE C CE1 1 
ATOM 2409 C CE2 . PHE A 1 387 ? 151.284 135.056 178.626 1.00 71.21  ? 387 PHE C CE2 1 
ATOM 2410 C CZ  . PHE A 1 387 ? 150.403 136.105 178.554 1.00 71.21  ? 387 PHE C CZ  1 
ATOM 2411 N N   . HIS A 1 388 ? 155.804 135.767 173.503 1.00 64.69  ? 388 HIS C N   1 
ATOM 2412 C CA  . HIS A 1 388 ? 156.731 135.188 172.551 1.00 64.69  ? 388 HIS C CA  1 
ATOM 2413 C C   . HIS A 1 388 ? 157.493 134.035 173.196 1.00 64.69  ? 388 HIS C C   1 
ATOM 2414 O O   . HIS A 1 388 ? 157.440 133.820 174.409 1.00 64.69  ? 388 HIS C O   1 
ATOM 2415 C CB  . HIS A 1 388 ? 157.709 136.245 172.051 1.00 64.69  ? 388 HIS C CB  1 
ATOM 2416 C CG  . HIS A 1 388 ? 157.089 137.592 171.861 1.00 64.69  ? 388 HIS C CG  1 
ATOM 2417 N ND1 . HIS A 1 388 ? 155.962 137.788 171.094 1.00 64.69  ? 388 HIS C ND1 1 
ATOM 2418 C CD2 . HIS A 1 388 ? 157.427 138.806 172.354 1.00 64.69  ? 388 HIS C CD2 1 
ATOM 2419 C CE1 . HIS A 1 388 ? 155.640 139.069 171.110 1.00 64.69  ? 388 HIS C CE1 1 
ATOM 2420 N NE2 . HIS A 1 388 ? 156.511 139.708 171.869 1.00 64.69  ? 388 HIS C NE2 1 
ATOM 2421 N N   . SER A 1 389 ? 158.205 133.285 172.363 1.00 63.33  ? 389 SER C N   1 
ATOM 2422 C CA  . SER A 1 389 ? 159.071 132.212 172.823 1.00 63.33  ? 389 SER C CA  1 
ATOM 2423 C C   . SER A 1 389 ? 160.376 132.259 172.041 1.00 63.33  ? 389 SER C C   1 
ATOM 2424 O O   . SER A 1 389 ? 160.430 132.744 170.908 1.00 63.33  ? 389 SER C O   1 
ATOM 2425 C CB  . SER A 1 389 ? 158.395 130.843 172.672 1.00 63.33  ? 389 SER C CB  1 
ATOM 2426 O OG  . SER A 1 389 ? 157.523 130.584 173.758 1.00 63.33  ? 389 SER C OG  1 
ATOM 2427 N N   . TYR A 1 390 ? 161.437 131.749 172.668 1.00 59.79  ? 390 TYR C N   1 
ATOM 2428 C CA  . TYR A 1 390 ? 162.765 131.722 172.066 1.00 59.79  ? 390 TYR C CA  1 
ATOM 2429 C C   . TYR A 1 390 ? 163.209 133.115 171.640 1.00 59.79  ? 390 TYR C C   1 
ATOM 2430 O O   . TYR A 1 390 ? 163.707 133.292 170.524 1.00 59.79  ? 390 TYR C O   1 
ATOM 2431 C CB  . TYR A 1 390 ? 162.800 130.779 170.859 1.00 59.79  ? 390 TYR C CB  1 
ATOM 2432 C CG  . TYR A 1 390 ? 162.409 129.350 171.161 1.00 59.79  ? 390 TYR C CG  1 
ATOM 2433 C CD1 . TYR A 1 390 ? 161.074 128.977 171.236 1.00 59.79  ? 390 TYR C CD1 1 
ATOM 2434 C CD2 . TYR A 1 390 ? 163.374 128.373 171.365 1.00 59.79  ? 390 TYR C CD2 1 
ATOM 2435 C CE1 . TYR A 1 390 ? 160.710 127.673 171.508 1.00 59.79  ? 390 TYR C CE1 1 
ATOM 2436 C CE2 . TYR A 1 390 ? 163.019 127.066 171.639 1.00 59.79  ? 390 TYR C CE2 1 
ATOM 2437 C CZ  . TYR A 1 390 ? 161.686 126.722 171.709 1.00 59.79  ? 390 TYR C CZ  1 
ATOM 2438 O OH  . TYR A 1 390 ? 161.325 125.423 171.981 1.00 59.79  ? 390 TYR C OH  1 
ATOM 2439 N N   . THR A 1 391 ? 163.036 134.110 172.506 1.00 53.79  ? 391 THR C N   1 
ATOM 2440 C CA  . THR A 1 391 ? 163.379 135.484 172.163 1.00 53.79  ? 391 THR C CA  1 
ATOM 2441 C C   . THR A 1 391 ? 163.926 136.182 173.404 1.00 53.79  ? 391 THR C C   1 
ATOM 2442 O O   . THR A 1 391 ? 164.042 135.587 174.480 1.00 53.79  ? 391 THR C O   1 
ATOM 2443 C CB  . THR A 1 391 ? 162.164 136.219 171.587 1.00 53.79  ? 391 THR C CB  1 
ATOM 2444 O OG1 . THR A 1 391 ? 162.586 137.459 171.007 1.00 53.79  ? 391 THR C OG1 1 
ATOM 2445 C CG2 . THR A 1 391 ? 161.164 136.506 172.682 1.00 53.79  ? 391 THR C CG2 1 
ATOM 2446 N N   . THR A 1 392 ? 164.258 137.463 173.248 1.00 49.59  ? 392 THR C N   1 
ATOM 2447 C CA  . THR A 1 392 ? 164.855 138.266 174.307 1.00 49.59  ? 392 THR C CA  1 
ATOM 2448 C C   . THR A 1 392 ? 164.166 139.620 174.349 1.00 49.59  ? 392 THR C C   1 
ATOM 2449 O O   . THR A 1 392 ? 163.845 140.185 173.299 1.00 49.59  ? 392 THR C O   1 
ATOM 2450 C CB  . THR A 1 392 ? 166.361 138.447 174.078 1.00 49.59  ? 392 THR C CB  1 
ATOM 2451 O OG1 . THR A 1 392 ? 166.994 137.165 174.026 1.00 49.59  ? 392 THR C OG1 1 
ATOM 2452 C CG2 . THR A 1 392 ? 166.987 139.264 175.195 1.00 49.59  ? 392 THR C CG2 1 
ATOM 2453 N N   . ILE A 1 393 ? 163.940 140.136 175.554 1.00 39.84  ? 393 ILE C N   1 
ATOM 2454 C CA  . ILE A 1 393 ? 163.309 141.433 175.756 1.00 39.84  ? 393 ILE C CA  1 
ATOM 2455 C C   . ILE A 1 393 ? 164.257 142.311 176.557 1.00 39.84  ? 393 ILE C C   1 
ATOM 2456 O O   . ILE A 1 393 ? 164.908 141.841 177.496 1.00 39.84  ? 393 ILE C O   1 
ATOM 2457 C CB  . ILE A 1 393 ? 161.954 141.313 176.481 1.00 39.84  ? 393 ILE C CB  1 
ATOM 2458 C CG1 . ILE A 1 393 ? 161.072 140.261 175.818 1.00 39.84  ? 393 ILE C CG1 1 
ATOM 2459 C CG2 . ILE A 1 393 ? 161.240 142.644 176.495 1.00 39.84  ? 393 ILE C CG2 1 
ATOM 2460 C CD1 . ILE A 1 393 ? 161.142 138.919 176.488 1.00 39.84  ? 393 ILE C CD1 1 
ATOM 2461 N N   . MET A 1 394 ? 164.331 143.584 176.190 1.00 40.31  ? 394 MET C N   1 
ATOM 2462 C CA  . MET A 1 394 ? 165.091 144.573 176.935 1.00 40.31  ? 394 MET C CA  1 
ATOM 2463 C C   . MET A 1 394 ? 164.146 145.595 177.553 1.00 40.31  ? 394 MET C C   1 
ATOM 2464 O O   . MET A 1 394 ? 162.943 145.613 177.280 1.00 40.31  ? 394 MET C O   1 
ATOM 2465 C CB  . MET A 1 394 ? 166.119 145.266 176.036 1.00 40.31  ? 394 MET C CB  1 
ATOM 2466 C CG  . MET A 1 394 ? 166.617 144.401 174.902 1.00 40.31  ? 394 MET C CG  1 
ATOM 2467 S SD  . MET A 1 394 ? 167.538 142.975 175.498 1.00 40.31  ? 394 MET C SD  1 
ATOM 2468 C CE  . MET A 1 394 ? 168.902 143.787 176.324 1.00 40.31  ? 394 MET C CE  1 
ATOM 2469 N N   . ALA A 1 395 ? 164.706 146.446 178.406 1.00 35.59  ? 395 ALA C N   1 
ATOM 2470 C CA  . ALA A 1 395 ? 163.946 147.511 179.044 1.00 35.59  ? 395 ALA C CA  1 
ATOM 2471 C C   . ALA A 1 395 ? 164.920 148.601 179.477 1.00 35.59  ? 395 ALA C C   1 
ATOM 2472 O O   . ALA A 1 395 ? 166.106 148.345 179.702 1.00 35.59  ? 395 ALA C O   1 
ATOM 2473 C CB  . ALA A 1 395 ? 163.122 146.966 180.215 1.00 35.59  ? 395 ALA C CB  1 
ATOM 2474 N N   . LEU A 1 396 ? 164.413 149.826 179.592 1.00 43.90  ? 396 LEU C N   1 
ATOM 2475 C CA  . LEU A 1 396 ? 165.231 150.970 179.972 1.00 43.90  ? 396 LEU C CA  1 
ATOM 2476 C C   . LEU A 1 396 ? 164.530 151.819 181.022 1.00 43.90  ? 396 LEU C C   1 
ATOM 2477 O O   . LEU A 1 396 ? 164.382 153.032 180.846 1.00 43.90  ? 396 LEU C O   1 
ATOM 2478 C CB  . LEU A 1 396 ? 165.578 151.819 178.751 1.00 43.90  ? 396 LEU C CB  1 
ATOM 2479 C CG  . LEU A 1 396 ? 167.057 152.182 178.651 1.00 43.90  ? 396 LEU C CG  1 
ATOM 2480 C CD1 . LEU A 1 396 ? 167.904 150.938 178.774 1.00 43.90  ? 396 LEU C CD1 1 
ATOM 2481 C CD2 . LEU A 1 396 ? 167.345 152.890 177.346 1.00 43.90  ? 396 LEU C CD2 1 
ATOM 2482 N N   . ILE A 1 397 ? 164.092 151.193 182.111 1.00 31.20  ? 397 ILE C N   1 
ATOM 2483 C CA  . ILE A 1 397 ? 163.256 151.856 183.103 1.00 31.20  ? 397 ILE C CA  1 
ATOM 2484 C C   . ILE A 1 397 ? 164.021 153.010 183.735 1.00 31.20  ? 397 ILE C C   1 
ATOM 2485 O O   . ILE A 1 397 ? 164.984 152.803 184.480 1.00 31.20  ? 397 ILE C O   1 
ATOM 2486 C CB  . ILE A 1 397 ? 162.787 150.858 184.174 1.00 31.20  ? 397 ILE C CB  1 
ATOM 2487 C CG1 . ILE A 1 397 ? 161.793 149.874 183.567 1.00 31.20  ? 397 ILE C CG1 1 
ATOM 2488 C CG2 . ILE A 1 397 ? 162.160 151.588 185.343 1.00 31.20  ? 397 ILE C CG2 1 
ATOM 2489 C CD1 . ILE A 1 397 ? 161.916 148.473 184.107 1.00 31.20  ? 397 ILE C CD1 1 
ATOM 2490 N N   . HIS A 1 398 ? 163.599 154.233 183.424 1.00 54.72  ? 398 HIS C N   1 
ATOM 2491 C CA  . HIS A 1 398 ? 164.222 155.438 183.953 1.00 54.72  ? 398 HIS C CA  1 
ATOM 2492 C C   . HIS A 1 398 ? 163.639 155.775 185.318 1.00 54.72  ? 398 HIS C C   1 
ATOM 2493 O O   . HIS A 1 398 ? 162.812 156.684 185.438 1.00 54.72  ? 398 HIS C O   1 
ATOM 2494 C CB  . HIS A 1 398 ? 164.024 156.600 182.978 1.00 54.72  ? 398 HIS C CB  1 
ATOM 2495 C CG  . HIS A 1 398 ? 164.791 157.835 183.334 1.00 54.72  ? 398 HIS C CG  1 
ATOM 2496 N ND1 . HIS A 1 398 ? 164.500 158.602 184.441 1.00 54.72  ? 398 HIS C ND1 1 
ATOM 2497 C CD2 . HIS A 1 398 ? 165.823 158.451 182.712 1.00 54.72  ? 398 HIS C CD2 1 
ATOM 2498 C CE1 . HIS A 1 398 ? 165.328 159.629 184.494 1.00 54.72  ? 398 HIS C CE1 1 
ATOM 2499 N NE2 . HIS A 1 398 ? 166.142 159.561 183.456 1.00 54.72  ? 398 HIS C NE2 1 
ATOM 2500 N N   . LEU A 1 399 ? 164.061 155.053 186.351 1.00 53.39  ? 399 LEU C N   1 
ATOM 2501 C CA  . LEU A 1 399 ? 163.535 155.250 187.699 1.00 53.39  ? 399 LEU C CA  1 
ATOM 2502 C C   . LEU A 1 399 ? 164.050 156.577 188.239 1.00 53.39  ? 399 LEU C C   1 
ATOM 2503 O O   . LEU A 1 399 ? 165.208 156.690 188.645 1.00 53.39  ? 399 LEU C O   1 
ATOM 2504 C CB  . LEU A 1 399 ? 163.943 154.090 188.601 1.00 53.39  ? 399 LEU C CB  1 
ATOM 2505 C CG  . LEU A 1 399 ? 163.005 153.697 189.746 1.00 53.39  ? 399 LEU C CG  1 
ATOM 2506 C CD1 . LEU A 1 399 ? 163.523 152.449 190.432 1.00 53.39  ? 399 LEU C CD1 1 
ATOM 2507 C CD2 . LEU A 1 399 ? 162.829 154.819 190.759 1.00 53.39  ? 399 LEU C CD2 1 
ATOM 2508 N N   . GLY A 1 400 ? 163.186 157.587 188.249 1.00 67.40  ? 400 GLY C N   1 
ATOM 2509 C CA  . GLY A 1 400 ? 163.552 158.890 188.767 1.00 67.40  ? 400 GLY C CA  1 
ATOM 2510 C C   . GLY A 1 400 ? 163.628 159.955 187.694 1.00 67.40  ? 400 GLY C C   1 
ATOM 2511 O O   . GLY A 1 400 ? 163.109 159.769 186.589 1.00 67.40  ? 400 GLY C O   1 
ATOM 2512 N N   . SER A 1 401 ? 164.275 161.073 188.006 1.00 83.84  ? 401 SER C N   1 
ATOM 2513 C CA  . SER A 1 401 ? 164.419 162.168 187.055 1.00 83.84  ? 401 SER C CA  1 
ATOM 2514 C C   . SER A 1 401 ? 165.581 163.079 187.437 1.00 83.84  ? 401 SER C C   1 
ATOM 2515 O O   . SER A 1 401 ? 165.607 164.254 187.072 1.00 83.84  ? 401 SER C O   1 
ATOM 2516 C CB  . SER A 1 401 ? 163.123 162.977 186.968 1.00 83.84  ? 401 SER C CB  1 
ATOM 2517 O OG  . SER A 1 401 ? 162.469 163.027 188.224 1.00 83.84  ? 401 SER C OG  1 
ATOM 2518 N N   . SER B 2 1   ? 140.052 182.722 198.814 1.00 132.53 ? 7   SER D N   1 
ATOM 2519 C CA  . SER B 2 1   ? 139.421 181.415 198.674 1.00 132.53 ? 7   SER D CA  1 
ATOM 2520 C C   . SER B 2 1   ? 139.477 180.926 197.232 1.00 132.53 ? 7   SER D C   1 
ATOM 2521 O O   . SER B 2 1   ? 138.469 180.488 196.678 1.00 132.53 ? 7   SER D O   1 
ATOM 2522 C CB  . SER B 2 1   ? 137.967 181.468 199.152 1.00 132.53 ? 7   SER D CB  1 
ATOM 2523 O OG  . SER B 2 1   ? 137.827 182.325 200.271 1.00 132.53 ? 7   SER D OG  1 
ATOM 2524 N N   . VAL B 2 2   ? 140.659 180.998 196.624 1.00 132.91 ? 8   VAL D N   1 
ATOM 2525 C CA  . VAL B 2 2   ? 140.823 180.576 195.238 1.00 132.91 ? 8   VAL D CA  1 
ATOM 2526 C C   . VAL B 2 2   ? 141.071 179.067 195.180 1.00 132.91 ? 8   VAL D C   1 
ATOM 2527 O O   . VAL B 2 2   ? 142.181 178.573 195.409 1.00 132.91 ? 8   VAL D O   1 
ATOM 2528 C CB  . VAL B 2 2   ? 141.898 181.433 194.526 1.00 132.91 ? 8   VAL D CB  1 
ATOM 2529 C CG1 . VAL B 2 2   ? 141.697 182.892 194.889 1.00 132.91 ? 8   VAL D CG1 1 
ATOM 2530 C CG2 . VAL B 2 2   ? 143.324 181.067 194.920 1.00 132.91 ? 8   VAL D CG2 1 
ATOM 2531 N N   . PHE B 2 3   ? 139.997 178.315 194.948 1.00 125.57 ? 9   PHE D N   1 
ATOM 2532 C CA  . PHE B 2 3   ? 140.089 176.865 194.835 1.00 125.57 ? 9   PHE D CA  1 
ATOM 2533 C C   . PHE B 2 3   ? 140.701 176.470 193.497 1.00 125.57 ? 9   PHE D C   1 
ATOM 2534 O O   . PHE B 2 3   ? 141.575 175.598 193.444 1.00 125.57 ? 9   PHE D O   1 
ATOM 2535 C CB  . PHE B 2 3   ? 138.704 176.237 195.032 1.00 125.57 ? 9   PHE D CB  1 
ATOM 2536 C CG  . PHE B 2 3   ? 138.477 174.967 194.254 1.00 125.57 ? 9   PHE D CG  1 
ATOM 2537 C CD1 . PHE B 2 3   ? 137.958 175.001 192.968 1.00 125.57 ? 9   PHE D CD1 1 
ATOM 2538 C CD2 . PHE B 2 3   ? 138.722 173.735 194.837 1.00 125.57 ? 9   PHE D CD2 1 
ATOM 2539 C CE1 . PHE B 2 3   ? 137.736 173.833 192.265 1.00 125.57 ? 9   PHE D CE1 1 
ATOM 2540 C CE2 . PHE B 2 3   ? 138.501 172.564 194.138 1.00 125.57 ? 9   PHE D CE2 1 
ATOM 2541 C CZ  . PHE B 2 3   ? 138.005 172.613 192.851 1.00 125.57 ? 9   PHE D CZ  1 
ATOM 2542 N N   . ALA B 2 4   ? 140.236 177.110 192.420 1.00 117.42 ? 10  ALA D N   1 
ATOM 2543 C CA  . ALA B 2 4   ? 140.685 176.866 191.052 1.00 117.42 ? 10  ALA D CA  1 
ATOM 2544 C C   . ALA B 2 4   ? 140.317 175.463 190.583 1.00 117.42 ? 10  ALA D C   1 
ATOM 2545 O O   . ALA B 2 4   ? 140.727 174.467 191.188 1.00 117.42 ? 10  ALA D O   1 
ATOM 2546 C CB  . ALA B 2 4   ? 142.193 177.098 190.919 1.00 117.42 ? 10  ALA D CB  1 
ATOM 2547 N N   . TYR B 2 5   ? 139.555 175.373 189.498 1.00 111.51 ? 11  TYR D N   1 
ATOM 2548 C CA  . TYR B 2 5   ? 139.161 174.097 188.928 1.00 111.51 ? 11  TYR D CA  1 
ATOM 2549 C C   . TYR B 2 5   ? 140.206 173.628 187.921 1.00 111.51 ? 11  TYR D C   1 
ATOM 2550 O O   . TYR B 2 5   ? 140.826 174.420 187.207 1.00 111.51 ? 11  TYR D O   1 
ATOM 2551 C CB  . TYR B 2 5   ? 137.778 174.205 188.281 1.00 111.51 ? 11  TYR D CB  1 
ATOM 2552 C CG  . TYR B 2 5   ? 136.996 172.912 188.266 1.00 111.51 ? 11  TYR D CG  1 
ATOM 2553 C CD1 . TYR B 2 5   ? 137.353 171.874 187.416 1.00 111.51 ? 11  TYR D CD1 1 
ATOM 2554 C CD2 . TYR B 2 5   ? 135.894 172.733 189.089 1.00 111.51 ? 11  TYR D CD2 1 
ATOM 2555 C CE1 . TYR B 2 5   ? 136.644 170.693 187.393 1.00 111.51 ? 11  TYR D CE1 1 
ATOM 2556 C CE2 . TYR B 2 5   ? 135.176 171.552 189.072 1.00 111.51 ? 11  TYR D CE2 1 
ATOM 2557 C CZ  . TYR B 2 5   ? 135.557 170.536 188.221 1.00 111.51 ? 11  TYR D CZ  1 
ATOM 2558 O OH  . TYR B 2 5   ? 134.850 169.358 188.197 1.00 111.51 ? 11  TYR D OH  1 
ATOM 2559 N N   . GLU B 2 6   ? 140.401 172.313 187.867 1.00 109.63 ? 12  GLU D N   1 
ATOM 2560 C CA  . GLU B 2 6   ? 141.298 171.710 186.892 1.00 109.63 ? 12  GLU D CA  1 
ATOM 2561 C C   . GLU B 2 6   ? 140.653 170.469 186.292 1.00 109.63 ? 12  GLU D C   1 
ATOM 2562 O O   . GLU B 2 6   ? 140.391 169.493 187.003 1.00 109.63 ? 12  GLU D O   1 
ATOM 2563 C CB  . GLU B 2 6   ? 142.642 171.362 187.536 1.00 109.63 ? 12  GLU D CB  1 
ATOM 2564 C CG  . GLU B 2 6   ? 143.599 172.540 187.711 1.00 109.63 ? 12  GLU D CG  1 
ATOM 2565 C CD  . GLU B 2 6   ? 144.072 173.137 186.394 1.00 109.63 ? 12  GLU D CD  1 
ATOM 2566 O OE1 . GLU B 2 6   ? 143.260 173.772 185.688 1.00 109.63 ? 12  GLU D OE1 1 
ATOM 2567 O OE2 . GLU B 2 6   ? 145.265 172.969 186.063 1.00 109.63 ? 12  GLU D OE2 1 
ATOM 2568 N N   . SER B 2 7   ? 140.392 170.497 184.989 1.00 96.77  ? 13  SER D N   1 
ATOM 2569 C CA  . SER B 2 7   ? 139.736 169.400 184.292 1.00 96.77  ? 13  SER D CA  1 
ATOM 2570 C C   . SER B 2 7   ? 140.735 168.718 183.372 1.00 96.77  ? 13  SER D C   1 
ATOM 2571 O O   . SER B 2 7   ? 141.365 169.374 182.536 1.00 96.77  ? 13  SER D O   1 
ATOM 2572 C CB  . SER B 2 7   ? 138.534 169.897 183.488 1.00 96.77  ? 13  SER D CB  1 
ATOM 2573 O OG  . SER B 2 7   ? 138.005 168.863 182.678 1.00 96.77  ? 13  SER D OG  1 
ATOM 2574 N N   . SER B 2 8   ? 140.875 167.405 183.527 1.00 90.72  ? 14  SER D N   1 
ATOM 2575 C CA  . SER B 2 8   ? 141.751 166.616 182.675 1.00 90.72  ? 14  SER D CA  1 
ATOM 2576 C C   . SER B 2 8   ? 141.058 166.119 181.415 1.00 90.72  ? 14  SER D C   1 
ATOM 2577 O O   . SER B 2 8   ? 141.680 165.399 180.627 1.00 90.72  ? 14  SER D O   1 
ATOM 2578 C CB  . SER B 2 8   ? 142.310 165.420 183.453 1.00 90.72  ? 14  SER D CB  1 
ATOM 2579 O OG  . SER B 2 8   ? 141.426 164.314 183.389 1.00 90.72  ? 14  SER D OG  1 
ATOM 2580 N N   . VAL B 2 9   ? 139.796 166.480 181.208 1.00 79.17  ? 15  VAL D N   1 
ATOM 2581 C CA  . VAL B 2 9   ? 139.022 166.008 180.071 1.00 79.17  ? 15  VAL D CA  1 
ATOM 2582 C C   . VAL B 2 9   ? 138.564 167.170 179.190 1.00 79.17  ? 15  VAL D C   1 
ATOM 2583 O O   . VAL B 2 9   ? 137.916 166.956 178.167 1.00 79.17  ? 15  VAL D O   1 
ATOM 2584 C CB  . VAL B 2 9   ? 137.833 165.148 180.535 1.00 79.17  ? 15  VAL D CB  1 
ATOM 2585 C CG1 . VAL B 2 9   ? 136.658 166.028 180.935 1.00 79.17  ? 15  VAL D CG1 1 
ATOM 2586 C CG2 . VAL B 2 9   ? 137.433 164.150 179.458 1.00 79.17  ? 15  VAL D CG2 1 
ATOM 2587 N N   . HIS B 2 10  ? 138.909 168.404 179.560 1.00 73.94  ? 16  HIS D N   1 
ATOM 2588 C CA  . HIS B 2 10  ? 138.464 169.574 178.816 1.00 73.94  ? 16  HIS D CA  1 
ATOM 2589 C C   . HIS B 2 10  ? 139.237 169.815 177.528 1.00 73.94  ? 16  HIS D C   1 
ATOM 2590 O O   . HIS B 2 10  ? 138.746 170.543 176.660 1.00 73.94  ? 16  HIS D O   1 
ATOM 2591 C CB  . HIS B 2 10  ? 138.556 170.833 179.682 1.00 73.94  ? 16  HIS D CB  1 
ATOM 2592 C CG  . HIS B 2 10  ? 137.900 172.025 179.064 1.00 73.94  ? 16  HIS D CG  1 
ATOM 2593 N ND1 . HIS B 2 10  ? 136.735 171.936 178.334 1.00 73.94  ? 16  HIS D ND1 1 
ATOM 2594 C CD2 . HIS B 2 10  ? 138.260 173.329 179.039 1.00 73.94  ? 16  HIS D CD2 1 
ATOM 2595 C CE1 . HIS B 2 10  ? 136.396 173.136 177.901 1.00 73.94  ? 16  HIS D CE1 1 
ATOM 2596 N NE2 . HIS B 2 10  ? 137.305 174.000 178.315 1.00 73.94  ? 16  HIS D NE2 1 
ATOM 2597 N N   . SER B 2 11  ? 140.420 169.226 177.372 1.00 59.37  ? 17  SER D N   1 
ATOM 2598 C CA  . SER B 2 11  ? 141.203 169.440 176.160 1.00 59.37  ? 17  SER D CA  1 
ATOM 2599 C C   . SER B 2 11  ? 140.908 168.365 175.117 1.00 59.37  ? 17  SER D C   1 
ATOM 2600 O O   . SER B 2 11  ? 140.746 168.666 173.929 1.00 59.37  ? 17  SER D O   1 
ATOM 2601 C CB  . SER B 2 11  ? 142.694 169.476 176.503 1.00 59.37  ? 17  SER D CB  1 
ATOM 2602 O OG  . SER B 2 11  ? 143.037 170.692 177.142 1.00 59.37  ? 17  SER D OG  1 
ATOM 2603 N N   . THR B 2 12  ? 140.830 167.108 175.555 1.00 59.10  ? 18  THR D N   1 
ATOM 2604 C CA  . THR B 2 12  ? 140.547 166.016 174.632 1.00 59.10  ? 18  THR D CA  1 
ATOM 2605 C C   . THR B 2 12  ? 139.174 166.182 173.995 1.00 59.10  ? 18  THR D C   1 
ATOM 2606 O O   . THR B 2 12  ? 139.008 165.985 172.786 1.00 59.10  ? 18  THR D O   1 
ATOM 2607 C CB  . THR B 2 12  ? 140.643 164.676 175.360 1.00 59.10  ? 18  THR D CB  1 
ATOM 2608 O OG1 . THR B 2 12  ? 141.926 164.562 175.987 1.00 59.10  ? 18  THR D OG1 1 
ATOM 2609 C CG2 . THR B 2 12  ? 140.462 163.528 174.382 1.00 59.10  ? 18  THR D CG2 1 
ATOM 2610 N N   . ASN B 2 13  ? 138.175 166.553 174.796 1.00 65.16  ? 19  ASN D N   1 
ATOM 2611 C CA  . ASN B 2 13  ? 136.837 166.756 174.254 1.00 65.16  ? 19  ASN D CA  1 
ATOM 2612 C C   . ASN B 2 13  ? 136.770 167.950 173.314 1.00 65.16  ? 19  ASN D C   1 
ATOM 2613 O O   . ASN B 2 13  ? 136.061 167.887 172.305 1.00 65.16  ? 19  ASN D O   1 
ATOM 2614 C CB  . ASN B 2 13  ? 135.827 166.928 175.384 1.00 65.16  ? 19  ASN D CB  1 
ATOM 2615 C CG  . ASN B 2 13  ? 135.663 165.672 176.210 1.00 65.16  ? 19  ASN D CG  1 
ATOM 2616 O OD1 . ASN B 2 13  ? 135.325 165.734 177.392 1.00 65.16  ? 19  ASN D OD1 1 
ATOM 2617 N ND2 . ASN B 2 13  ? 135.904 164.522 175.593 1.00 65.16  ? 19  ASN D ND2 1 
ATOM 2618 N N   . VAL B 2 14  ? 137.484 169.035 173.618 1.00 58.45  ? 20  VAL D N   1 
ATOM 2619 C CA  . VAL B 2 14  ? 137.505 170.168 172.702 1.00 58.45  ? 20  VAL D CA  1 
ATOM 2620 C C   . VAL B 2 14  ? 138.148 169.778 171.377 1.00 58.45  ? 20  VAL D C   1 
ATOM 2621 O O   . VAL B 2 14  ? 137.636 170.131 170.306 1.00 58.45  ? 20  VAL D O   1 
ATOM 2622 C CB  . VAL B 2 14  ? 138.217 171.369 173.347 1.00 58.45  ? 20  VAL D CB  1 
ATOM 2623 C CG1 . VAL B 2 14  ? 138.815 172.278 172.287 1.00 58.45  ? 20  VAL D CG1 1 
ATOM 2624 C CG2 . VAL B 2 14  ? 137.249 172.144 174.218 1.00 58.45  ? 20  VAL D CG2 1 
ATOM 2625 N N   . LEU B 2 15  ? 139.257 169.037 171.413 1.00 55.06  ? 21  LEU D N   1 
ATOM 2626 C CA  . LEU B 2 15  ? 139.896 168.618 170.171 1.00 55.06  ? 21  LEU D CA  1 
ATOM 2627 C C   . LEU B 2 15  ? 139.083 167.580 169.408 1.00 55.06  ? 21  LEU D C   1 
ATOM 2628 O O   . LEU B 2 15  ? 139.197 167.510 168.180 1.00 55.06  ? 21  LEU D O   1 
ATOM 2629 C CB  . LEU B 2 15  ? 141.300 168.079 170.443 1.00 55.06  ? 21  LEU D CB  1 
ATOM 2630 C CG  . LEU B 2 15  ? 142.441 169.094 170.342 1.00 55.06  ? 21  LEU D CG  1 
ATOM 2631 C CD1 . LEU B 2 15  ? 142.770 169.359 168.886 1.00 55.06  ? 21  LEU D CD1 1 
ATOM 2632 C CD2 . LEU B 2 15  ? 142.104 170.394 171.051 1.00 55.06  ? 21  LEU D CD2 1 
ATOM 2633 N N   . LEU B 2 16  ? 138.272 166.775 170.096 1.00 57.73  ? 22  LEU D N   1 
ATOM 2634 C CA  . LEU B 2 16  ? 137.353 165.882 169.399 1.00 57.73  ? 22  LEU D CA  1 
ATOM 2635 C C   . LEU B 2 16  ? 136.178 166.627 168.782 1.00 57.73  ? 22  LEU D C   1 
ATOM 2636 O O   . LEU B 2 16  ? 135.743 166.272 167.680 1.00 57.73  ? 22  LEU D O   1 
ATOM 2637 C CB  . LEU B 2 16  ? 136.836 164.797 170.346 1.00 57.73  ? 22  LEU D CB  1 
ATOM 2638 C CG  . LEU B 2 16  ? 137.627 163.488 170.452 1.00 57.73  ? 22  LEU D CG  1 
ATOM 2639 C CD1 . LEU B 2 16  ? 137.278 162.570 169.292 1.00 57.73  ? 22  LEU D CD1 1 
ATOM 2640 C CD2 . LEU B 2 16  ? 139.128 163.721 170.504 1.00 57.73  ? 22  LEU D CD2 1 
ATOM 2641 N N   . SER B 2 17  ? 135.658 167.648 169.462 1.00 58.97  ? 23  SER D N   1 
ATOM 2642 C CA  . SER B 2 17  ? 134.636 168.500 168.873 1.00 58.97  ? 23  SER D CA  1 
ATOM 2643 C C   . SER B 2 17  ? 135.151 169.259 167.660 1.00 58.97  ? 23  SER D C   1 
ATOM 2644 O O   . SER B 2 17  ? 134.406 169.424 166.689 1.00 58.97  ? 23  SER D O   1 
ATOM 2645 C CB  . SER B 2 17  ? 134.105 169.485 169.912 1.00 58.97  ? 23  SER D CB  1 
ATOM 2646 O OG  . SER B 2 17  ? 133.274 168.829 170.851 1.00 58.97  ? 23  SER D OG  1 
ATOM 2647 N N   . LEU B 2 18  ? 136.400 169.721 167.692 1.00 58.21  ? 24  LEU D N   1 
ATOM 2648 C CA  . LEU B 2 18  ? 137.006 170.308 166.505 1.00 58.21  ? 24  LEU D CA  1 
ATOM 2649 C C   . LEU B 2 18  ? 137.084 169.326 165.344 1.00 58.21  ? 24  LEU D C   1 
ATOM 2650 O O   . LEU B 2 18  ? 136.776 169.706 164.210 1.00 58.21  ? 24  LEU D O   1 
ATOM 2651 C CB  . LEU B 2 18  ? 138.404 170.838 166.827 1.00 58.21  ? 24  LEU D CB  1 
ATOM 2652 C CG  . LEU B 2 18  ? 138.451 171.993 167.825 1.00 58.21  ? 24  LEU D CG  1 
ATOM 2653 C CD1 . LEU B 2 18  ? 139.881 172.420 168.090 1.00 58.21  ? 24  LEU D CD1 1 
ATOM 2654 C CD2 . LEU B 2 18  ? 137.629 173.157 167.322 1.00 58.21  ? 24  LEU D CD2 1 
ATOM 2655 N N   . ASN B 2 19  ? 137.465 168.073 165.597 1.00 58.42  ? 25  ASN D N   1 
ATOM 2656 C CA  . ASN B 2 19  ? 137.425 167.040 164.572 1.00 58.42  ? 25  ASN D CA  1 
ATOM 2657 C C   . ASN B 2 19  ? 136.030 166.804 164.016 1.00 58.42  ? 25  ASN D C   1 
ATOM 2658 O O   . ASN B 2 19  ? 135.873 166.717 162.791 1.00 58.42  ? 25  ASN D O   1 
ATOM 2659 C CB  . ASN B 2 19  ? 137.953 165.714 165.128 1.00 58.42  ? 25  ASN D CB  1 
ATOM 2660 C CG  . ASN B 2 19  ? 138.588 164.851 164.062 1.00 58.42  ? 25  ASN D CG  1 
ATOM 2661 O OD1 . ASN B 2 19  ? 139.057 165.351 163.042 1.00 58.42  ? 25  ASN D OD1 1 
ATOM 2662 N ND2 . ASN B 2 19  ? 138.577 163.541 164.277 1.00 58.42  ? 25  ASN D ND2 1 
ATOM 2663 N N   . ASP B 2 20  ? 135.026 166.698 164.880 1.00 62.67  ? 26  ASP D N   1 
ATOM 2664 C CA  . ASP B 2 20  ? 133.649 166.523 164.441 1.00 62.67  ? 26  ASP D CA  1 
ATOM 2665 C C   . ASP B 2 20  ? 133.151 167.697 163.613 1.00 62.67  ? 26  ASP D C   1 
ATOM 2666 O O   . ASP B 2 20  ? 132.448 167.483 162.621 1.00 62.67  ? 26  ASP D O   1 
ATOM 2667 C CB  . ASP B 2 20  ? 132.728 166.316 165.646 1.00 62.67  ? 26  ASP D CB  1 
ATOM 2668 C CG  . ASP B 2 20  ? 131.263 166.357 165.268 1.00 62.67  ? 26  ASP D CG  1 
ATOM 2669 O OD1 . ASP B 2 20  ? 130.742 165.326 164.794 1.00 62.67  ? 26  ASP D OD1 1 
ATOM 2670 O OD2 . ASP B 2 20  ? 130.634 167.422 165.437 1.00 62.67  ? 26  ASP D OD2 1 
ATOM 2671 N N   . GLN B 2 21  ? 133.500 168.922 163.991 1.00 63.24  ? 27  GLN D N   1 
ATOM 2672 C CA  . GLN B 2 21  ? 133.206 170.093 163.182 1.00 63.24  ? 27  GLN D CA  1 
ATOM 2673 C C   . GLN B 2 21  ? 133.937 170.075 161.848 1.00 63.24  ? 27  GLN D C   1 
ATOM 2674 O O   . GLN B 2 21  ? 133.394 170.567 160.853 1.00 63.24  ? 27  GLN D O   1 
ATOM 2675 C CB  . GLN B 2 21  ? 133.575 171.365 163.949 1.00 63.24  ? 27  GLN D CB  1 
ATOM 2676 C CG  . GLN B 2 21  ? 132.694 171.636 165.151 1.00 63.24  ? 27  GLN D CG  1 
ATOM 2677 C CD  . GLN B 2 21  ? 132.490 173.112 165.397 1.00 63.24  ? 27  GLN D CD  1 
ATOM 2678 O OE1 . GLN B 2 21  ? 133.425 173.904 165.293 1.00 63.24  ? 27  GLN D OE1 1 
ATOM 2679 N NE2 . GLN B 2 21  ? 131.262 173.492 165.724 1.00 63.24  ? 27  GLN D NE2 1 
ATOM 2680 N N   . ARG B 2 22  ? 135.151 169.529 161.809 1.00 65.19  ? 28  ARG D N   1 
ATOM 2681 C CA  . ARG B 2 22  ? 135.896 169.395 160.565 1.00 65.19  ? 28  ARG D CA  1 
ATOM 2682 C C   . ARG B 2 22  ? 135.219 168.423 159.609 1.00 65.19  ? 28  ARG D C   1 
ATOM 2683 O O   . ARG B 2 22  ? 135.087 168.712 158.415 1.00 65.19  ? 28  ARG D O   1 
ATOM 2684 C CB  . ARG B 2 22  ? 137.323 168.920 160.841 1.00 65.19  ? 28  ARG D CB  1 
ATOM 2685 C CG  . ARG B 2 22  ? 138.279 169.147 159.686 1.00 65.19  ? 28  ARG D CG  1 
ATOM 2686 C CD  . ARG B 2 22  ? 139.585 168.402 159.899 1.00 65.19  ? 28  ARG D CD  1 
ATOM 2687 N NE  . ARG B 2 22  ? 139.642 167.186 159.097 1.00 65.19  ? 28  ARG D NE  1 
ATOM 2688 C CZ  . ARG B 2 22  ? 139.679 165.958 159.597 1.00 65.19  ? 28  ARG D CZ  1 
ATOM 2689 N NH1 . ARG B 2 22  ? 139.671 165.743 160.901 1.00 65.19  ? 28  ARG D NH1 1 
ATOM 2690 N NH2 . ARG B 2 22  ? 139.723 164.921 158.767 1.00 65.19  ? 28  ARG D NH2 1 
ATOM 2691 N N   . LYS B 2 23  ? 134.796 167.268 160.122 1.00 64.40  ? 29  LYS D N   1 
ATOM 2692 C CA  . LYS B 2 23  ? 134.292 166.200 159.264 1.00 64.40  ? 29  LYS D CA  1 
ATOM 2693 C C   . LYS B 2 23  ? 133.067 166.615 158.459 1.00 64.40  ? 29  LYS D C   1 
ATOM 2694 O O   . LYS B 2 23  ? 133.008 166.372 157.250 1.00 64.40  ? 29  LYS D O   1 
ATOM 2695 C CB  . LYS B 2 23  ? 133.967 164.954 160.089 1.00 64.40  ? 29  LYS D CB  1 
ATOM 2696 C CG  . LYS B 2 23  ? 135.173 164.084 160.392 1.00 64.40  ? 29  LYS D CG  1 
ATOM 2697 C CD  . LYS B 2 23  ? 134.777 162.852 161.185 1.00 64.40  ? 29  LYS D CD  1 
ATOM 2698 C CE  . LYS B 2 23  ? 135.991 162.176 161.797 1.00 64.40  ? 29  LYS D CE  1 
ATOM 2699 N NZ  . LYS B 2 23  ? 135.606 161.026 162.658 1.00 64.40  ? 29  LYS D NZ  1 
ATOM 2700 N N   . LYS B 2 24  ? 132.084 167.240 159.107 1.00 68.99  ? 30  LYS D N   1 
ATOM 2701 C CA  . LYS B 2 24  ? 130.837 167.604 158.433 1.00 68.99  ? 30  LYS D CA  1 
ATOM 2702 C C   . LYS B 2 24  ? 130.802 169.100 158.110 1.00 68.99  ? 30  LYS D C   1 
ATOM 2703 O O   . LYS B 2 24  ? 129.747 169.725 158.005 1.00 68.99  ? 30  LYS D O   1 
ATOM 2704 C CB  . LYS B 2 24  ? 129.641 167.180 159.276 1.00 68.99  ? 30  LYS D CB  1 
ATOM 2705 C CG  . LYS B 2 24  ? 129.834 167.351 160.769 1.00 68.99  ? 30  LYS D CG  1 
ATOM 2706 C CD  . LYS B 2 24  ? 128.788 166.574 161.552 1.00 68.99  ? 30  LYS D CD  1 
ATOM 2707 C CE  . LYS B 2 24  ? 127.394 167.132 161.330 1.00 68.99  ? 30  LYS D CE  1 
ATOM 2708 N NZ  . LYS B 2 24  ? 127.279 168.538 161.802 1.00 68.99  ? 30  LYS D NZ  1 
ATOM 2709 N N   . ASP B 2 25  ? 132.000 169.665 157.940 1.00 70.09  ? 31  ASP D N   1 
ATOM 2710 C CA  . ASP B 2 25  ? 132.183 171.040 157.482 1.00 70.09  ? 31  ASP D CA  1 
ATOM 2711 C C   . ASP B 2 25  ? 131.382 172.040 158.304 1.00 70.09  ? 31  ASP D C   1 
ATOM 2712 O O   . ASP B 2 25  ? 130.620 172.838 157.749 1.00 70.09  ? 31  ASP D O   1 
ATOM 2713 C CB  . ASP B 2 25  ? 131.799 171.158 156.007 1.00 70.09  ? 31  ASP D CB  1 
ATOM 2714 C CG  . ASP B 2 25  ? 132.584 170.215 155.125 1.00 70.09  ? 31  ASP D CG  1 
ATOM 2715 O OD1 . ASP B 2 25  ? 132.964 169.129 155.611 1.00 70.09  ? 31  ASP D OD1 1 
ATOM 2716 O OD2 . ASP B 2 25  ? 132.818 170.555 153.947 1.00 70.09  ? 31  ASP D OD2 1 
ATOM 2717 N N   . VAL B 2 26  ? 131.544 172.010 159.619 1.00 71.50  ? 32  VAL D N   1 
ATOM 2718 C CA  . VAL B 2 26  ? 130.813 172.891 160.519 1.00 71.50  ? 32  VAL D CA  1 
ATOM 2719 C C   . VAL B 2 26  ? 131.752 174.038 160.871 1.00 71.50  ? 32  VAL D C   1 
ATOM 2720 O O   . VAL B 2 26  ? 132.662 173.881 161.694 1.00 71.50  ? 32  VAL D O   1 
ATOM 2721 C CB  . VAL B 2 26  ? 130.321 172.141 161.765 1.00 71.50  ? 32  VAL D CB  1 
ATOM 2722 C CG1 . VAL B 2 26  ? 129.471 173.037 162.641 1.00 71.50  ? 32  VAL D CG1 1 
ATOM 2723 C CG2 . VAL B 2 26  ? 129.544 170.902 161.358 1.00 71.50  ? 32  VAL D CG2 1 
ATOM 2724 N N   . LEU B 2 27  ? 131.534 175.190 160.239 1.00 74.46  ? 33  LEU D N   1 
ATOM 2725 C CA  . LEU B 2 27  ? 132.391 176.372 160.297 1.00 74.46  ? 33  LEU D CA  1 
ATOM 2726 C C   . LEU B 2 27  ? 133.841 176.089 159.926 1.00 74.46  ? 33  LEU D C   1 
ATOM 2727 O O   . LEU B 2 27  ? 134.749 176.526 160.639 1.00 74.46  ? 33  LEU D O   1 
ATOM 2728 C CB  . LEU B 2 27  ? 132.355 177.074 161.663 1.00 74.46  ? 33  LEU D CB  1 
ATOM 2729 C CG  . LEU B 2 27  ? 131.064 177.258 162.457 1.00 74.46  ? 33  LEU D CG  1 
ATOM 2730 C CD1 . LEU B 2 27  ? 130.806 176.092 163.373 1.00 74.46  ? 33  LEU D CD1 1 
ATOM 2731 C CD2 . LEU B 2 27  ? 131.130 178.549 163.241 1.00 74.46  ? 33  LEU D CD2 1 
ATOM 2732 N N   . CYS B 2 28  ? 134.091 175.348 158.850 1.00 84.79  ? 34  CYS D N   1 
ATOM 2733 C CA  . CYS B 2 28  ? 135.434 175.303 158.288 1.00 84.79  ? 34  CYS D CA  1 
ATOM 2734 C C   . CYS B 2 28  ? 135.676 176.552 157.449 1.00 84.79  ? 34  CYS D C   1 
ATOM 2735 O O   . CYS B 2 28  ? 134.927 176.833 156.510 1.00 84.79  ? 34  CYS D O   1 
ATOM 2736 C CB  . CYS B 2 28  ? 135.615 174.047 157.438 1.00 84.79  ? 34  CYS D CB  1 
ATOM 2737 S SG  . CYS B 2 28  ? 135.559 172.498 158.367 1.00 84.79  ? 34  CYS D SG  1 
ATOM 2738 N N   . ASP B 2 29  ? 136.725 177.308 157.788 1.00 82.83  ? 35  ASP D N   1 
ATOM 2739 C CA  . ASP B 2 29  ? 136.982 178.574 157.113 1.00 82.83  ? 35  ASP D CA  1 
ATOM 2740 C C   . ASP B 2 29  ? 138.277 178.580 156.311 1.00 82.83  ? 35  ASP D C   1 
ATOM 2741 O O   . ASP B 2 29  ? 138.707 179.652 155.871 1.00 82.83  ? 35  ASP D O   1 
ATOM 2742 C CB  . ASP B 2 29  ? 137.000 179.734 158.116 1.00 82.83  ? 35  ASP D CB  1 
ATOM 2743 C CG  . ASP B 2 29  ? 135.959 179.583 159.206 1.00 82.83  ? 35  ASP D CG  1 
ATOM 2744 O OD1 . ASP B 2 29  ? 136.101 178.666 160.035 1.00 82.83  ? 35  ASP D OD1 1 
ATOM 2745 O OD2 . ASP B 2 29  ? 134.994 180.377 159.227 1.00 82.83  ? 35  ASP D OD2 1 
ATOM 2746 N N   . VAL B 2 30  ? 138.913 177.429 156.108 1.00 81.33  ? 36  VAL D N   1 
ATOM 2747 C CA  . VAL B 2 30  ? 140.125 177.352 155.303 1.00 81.33  ? 36  VAL D CA  1 
ATOM 2748 C C   . VAL B 2 30  ? 140.074 176.099 154.439 1.00 81.33  ? 36  VAL D C   1 
ATOM 2749 O O   . VAL B 2 30  ? 139.642 175.029 154.879 1.00 81.33  ? 36  VAL D O   1 
ATOM 2750 C CB  . VAL B 2 30  ? 141.400 177.382 156.179 1.00 81.33  ? 36  VAL D CB  1 
ATOM 2751 C CG1 . VAL B 2 30  ? 141.465 176.173 157.097 1.00 81.33  ? 36  VAL D CG1 1 
ATOM 2752 C CG2 . VAL B 2 30  ? 142.645 177.473 155.310 1.00 81.33  ? 36  VAL D CG2 1 
ATOM 2753 N N   . THR B 2 31  ? 140.490 176.252 153.184 1.00 81.43  ? 37  THR D N   1 
ATOM 2754 C CA  . THR B 2 31  ? 140.608 175.144 152.249 1.00 81.43  ? 37  THR D CA  1 
ATOM 2755 C C   . THR B 2 31  ? 142.056 175.050 151.796 1.00 81.43  ? 37  THR D C   1 
ATOM 2756 O O   . THR B 2 31  ? 142.670 176.061 151.444 1.00 81.43  ? 37  THR D O   1 
ATOM 2757 C CB  . THR B 2 31  ? 139.683 175.327 151.040 1.00 81.43  ? 37  THR D CB  1 
ATOM 2758 O OG1 . THR B 2 31  ? 138.366 175.665 151.494 1.00 81.43  ? 37  THR D OG1 1 
ATOM 2759 C CG2 . THR B 2 31  ? 139.611 174.048 150.227 1.00 81.43  ? 37  THR D CG2 1 
ATOM 2760 N N   . ILE B 2 32  ? 142.604 173.839 151.819 1.00 75.86  ? 38  ILE D N   1 
ATOM 2761 C CA  . ILE B 2 32  ? 144.007 173.598 151.495 1.00 75.86  ? 38  ILE D CA  1 
ATOM 2762 C C   . ILE B 2 32  ? 144.052 172.547 150.392 1.00 75.86  ? 38  ILE D C   1 
ATOM 2763 O O   . ILE B 2 32  ? 143.258 171.599 150.390 1.00 75.86  ? 38  ILE D O   1 
ATOM 2764 C CB  . ILE B 2 32  ? 144.824 173.165 152.717 1.00 75.86  ? 38  ILE D CB  1 
ATOM 2765 C CG1 . ILE B 2 32  ? 144.384 171.786 153.204 1.00 75.86  ? 38  ILE D CG1 1 
ATOM 2766 C CG2 . ILE B 2 32  ? 144.699 174.183 153.837 1.00 75.86  ? 38  ILE D CG2 1 
ATOM 2767 C CD1 . ILE B 2 32  ? 145.460 171.034 153.913 1.00 75.86  ? 38  ILE D CD1 1 
ATOM 2768 N N   . PHE B 2 33  ? 144.944 172.738 149.425 1.00 73.57  ? 39  PHE D N   1 
ATOM 2769 C CA  . PHE B 2 33  ? 145.126 171.771 148.358 1.00 73.57  ? 39  PHE D CA  1 
ATOM 2770 C C   . PHE B 2 33  ? 146.468 171.059 148.502 1.00 73.57  ? 39  PHE D C   1 
ATOM 2771 O O   . PHE B 2 33  ? 147.514 171.674 148.719 1.00 73.57  ? 39  PHE D O   1 
ATOM 2772 C CB  . PHE B 2 33  ? 145.045 172.448 146.992 1.00 73.57  ? 39  PHE D CB  1 
ATOM 2773 C CG  . PHE B 2 33  ? 143.781 173.224 146.768 1.00 73.57  ? 39  PHE D CG  1 
ATOM 2774 C CD1 . PHE B 2 33  ? 142.564 172.578 146.661 1.00 73.57  ? 39  PHE D CD1 1 
ATOM 2775 C CD2 . PHE B 2 33  ? 143.814 174.603 146.652 1.00 73.57  ? 39  PHE D CD2 1 
ATOM 2776 C CE1 . PHE B 2 33  ? 141.403 173.294 146.446 1.00 73.57  ? 39  PHE D CE1 1 
ATOM 2777 C CE2 . PHE B 2 33  ? 142.657 175.324 146.440 1.00 73.57  ? 39  PHE D CE2 1 
ATOM 2778 C CZ  . PHE B 2 33  ? 141.450 174.668 146.337 1.00 73.57  ? 39  PHE D CZ  1 
ATOM 2779 N N   . VAL B 2 34  ? 146.425 169.736 148.376 1.00 72.26  ? 40  VAL D N   1 
ATOM 2780 C CA  . VAL B 2 34  ? 147.630 168.923 148.268 1.00 72.26  ? 40  VAL D CA  1 
ATOM 2781 C C   . VAL B 2 34  ? 147.459 168.068 147.023 1.00 72.26  ? 40  VAL D C   1 
ATOM 2782 O O   . VAL B 2 34  ? 146.529 167.257 146.949 1.00 72.26  ? 40  VAL D O   1 
ATOM 2783 C CB  . VAL B 2 34  ? 147.854 168.064 149.526 1.00 72.26  ? 40  VAL D CB  1 
ATOM 2784 C CG1 . VAL B 2 34  ? 148.681 166.834 149.194 1.00 72.26  ? 40  VAL D CG1 1 
ATOM 2785 C CG2 . VAL B 2 34  ? 148.520 168.886 150.615 1.00 72.26  ? 40  VAL D CG2 1 
ATOM 2786 N N   . GLU B 2 35  ? 148.344 168.245 146.040 1.00 76.28  ? 41  GLU D N   1 
ATOM 2787 C CA  . GLU B 2 35  ? 148.097 167.740 144.693 1.00 76.28  ? 41  GLU D CA  1 
ATOM 2788 C C   . GLU B 2 35  ? 146.700 168.183 144.285 1.00 76.28  ? 41  GLU D C   1 
ATOM 2789 O O   . GLU B 2 35  ? 146.408 169.383 144.291 1.00 76.28  ? 41  GLU D O   1 
ATOM 2790 C CB  . GLU B 2 35  ? 148.242 166.219 144.635 1.00 76.28  ? 41  GLU D CB  1 
ATOM 2791 C CG  . GLU B 2 35  ? 149.515 165.695 145.275 1.00 76.28  ? 41  GLU D CG  1 
ATOM 2792 C CD  . GLU B 2 35  ? 149.946 164.365 144.695 1.00 76.28  ? 41  GLU D CD  1 
ATOM 2793 O OE1 . GLU B 2 35  ? 151.162 164.170 144.487 1.00 76.28  ? 41  GLU D OE1 1 
ATOM 2794 O OE2 . GLU B 2 35  ? 149.067 163.514 144.445 1.00 76.28  ? 41  GLU D OE2 1 
ATOM 2795 N N   . GLY B 2 36  ? 145.824 167.244 143.937 1.00 72.92  ? 42  GLY D N   1 
ATOM 2796 C CA  . GLY B 2 36  ? 144.418 167.551 144.089 1.00 72.92  ? 42  GLY D CA  1 
ATOM 2797 C C   . GLY B 2 36  ? 143.649 166.490 144.847 1.00 72.92  ? 42  GLY D C   1 
ATOM 2798 O O   . GLY B 2 36  ? 143.266 165.459 144.288 1.00 72.92  ? 42  GLY D O   1 
ATOM 2799 N N   . GLN B 2 37  ? 143.387 166.773 146.123 1.00 76.18  ? 43  GLN D N   1 
ATOM 2800 C CA  . GLN B 2 37  ? 142.381 166.124 146.956 1.00 76.18  ? 43  GLN D CA  1 
ATOM 2801 C C   . GLN B 2 37  ? 142.007 167.141 148.023 1.00 76.18  ? 43  GLN D C   1 
ATOM 2802 O O   . GLN B 2 37  ? 142.758 167.321 148.984 1.00 76.18  ? 43  GLN D O   1 
ATOM 2803 C CB  . GLN B 2 37  ? 142.844 164.825 147.646 1.00 76.18  ? 43  GLN D CB  1 
ATOM 2804 C CG  . GLN B 2 37  ? 143.382 163.655 146.806 1.00 76.18  ? 43  GLN D CG  1 
ATOM 2805 C CD  . GLN B 2 37  ? 144.788 163.849 146.262 1.00 76.18  ? 43  GLN D CD  1 
ATOM 2806 O OE1 . GLN B 2 37  ? 145.361 164.931 146.334 1.00 76.18  ? 43  GLN D OE1 1 
ATOM 2807 N NE2 . GLN B 2 37  ? 145.350 162.782 145.706 1.00 76.18  ? 43  GLN D NE2 1 
ATOM 2808 N N   . ARG B 2 38  ? 140.879 167.823 147.863 1.00 80.77  ? 44  ARG D N   1 
ATOM 2809 C CA  . ARG B 2 38  ? 140.549 168.951 148.724 1.00 80.77  ? 44  ARG D CA  1 
ATOM 2810 C C   . ARG B 2 38  ? 140.423 168.535 150.183 1.00 80.77  ? 44  ARG D C   1 
ATOM 2811 O O   . ARG B 2 38  ? 139.741 167.559 150.508 1.00 80.77  ? 44  ARG D O   1 
ATOM 2812 C CB  . ARG B 2 38  ? 139.247 169.596 148.249 1.00 80.77  ? 44  ARG D CB  1 
ATOM 2813 C CG  . ARG B 2 38  ? 139.327 171.106 148.116 1.00 80.77  ? 44  ARG D CG  1 
ATOM 2814 C CD  . ARG B 2 38  ? 138.004 171.764 147.718 1.00 80.77  ? 44  ARG D CD  1 
ATOM 2815 N NE  . ARG B 2 38  ? 136.874 171.371 148.555 1.00 80.77  ? 44  ARG D NE  1 
ATOM 2816 C CZ  . ARG B 2 38  ? 136.063 170.351 148.305 1.00 80.77  ? 44  ARG D CZ  1 
ATOM 2817 N NH1 . ARG B 2 38  ? 136.195 169.612 147.216 1.00 80.77  ? 44  ARG D NH1 1 
ATOM 2818 N NH2 . ARG B 2 38  ? 135.088 170.073 149.165 1.00 80.77  ? 44  ARG D NH2 1 
ATOM 2819 N N   . PHE B 2 39  ? 141.087 169.282 151.062 1.00 72.29  ? 45  PHE D N   1 
ATOM 2820 C CA  . PHE B 2 39  ? 140.951 169.118 152.502 1.00 72.29  ? 45  PHE D CA  1 
ATOM 2821 C C   . PHE B 2 39  ? 140.360 170.377 153.127 1.00 72.29  ? 45  PHE D C   1 
ATOM 2822 O O   . PHE B 2 39  ? 140.538 171.492 152.631 1.00 72.29  ? 45  PHE D O   1 
ATOM 2823 C CB  . PHE B 2 39  ? 142.297 168.809 153.159 1.00 72.29  ? 45  PHE D CB  1 
ATOM 2824 C CG  . PHE B 2 39  ? 142.760 167.397 152.969 1.00 72.29  ? 45  PHE D CG  1 
ATOM 2825 C CD1 . PHE B 2 39  ? 143.465 167.032 151.841 1.00 72.29  ? 45  PHE D CD1 1 
ATOM 2826 C CD2 . PHE B 2 39  ? 142.490 166.434 153.924 1.00 72.29  ? 45  PHE D CD2 1 
ATOM 2827 C CE1 . PHE B 2 39  ? 143.891 165.735 151.663 1.00 72.29  ? 45  PHE D CE1 1 
ATOM 2828 C CE2 . PHE B 2 39  ? 142.914 165.135 153.753 1.00 72.29  ? 45  PHE D CE2 1 
ATOM 2829 C CZ  . PHE B 2 39  ? 143.616 164.785 152.621 1.00 72.29  ? 45  PHE D CZ  1 
ATOM 2830 N N   . ARG B 2 40  ? 139.656 170.184 154.238 1.00 78.64  ? 46  ARG D N   1 
ATOM 2831 C CA  . ARG B 2 40  ? 139.052 171.278 154.980 1.00 78.64  ? 46  ARG D CA  1 
ATOM 2832 C C   . ARG B 2 40  ? 139.516 171.218 156.427 1.00 78.64  ? 46  ARG D C   1 
ATOM 2833 O O   . ARG B 2 40  ? 139.672 170.136 156.999 1.00 78.64  ? 46  ARG D O   1 
ATOM 2834 C CB  . ARG B 2 40  ? 137.522 171.221 154.918 1.00 78.64  ? 46  ARG D CB  1 
ATOM 2835 C CG  . ARG B 2 40  ? 136.935 171.811 153.650 1.00 78.64  ? 46  ARG D CG  1 
ATOM 2836 C CD  . ARG B 2 40  ? 136.772 173.315 153.760 1.00 78.64  ? 46  ARG D CD  1 
ATOM 2837 N NE  . ARG B 2 40  ? 135.370 173.706 153.835 1.00 78.64  ? 46  ARG D NE  1 
ATOM 2838 C CZ  . ARG B 2 40  ? 134.946 174.960 153.899 1.00 78.64  ? 46  ARG D CZ  1 
ATOM 2839 N NH1 . ARG B 2 40  ? 135.793 175.976 153.894 1.00 78.64  ? 46  ARG D NH1 1 
ATOM 2840 N NH2 . ARG B 2 40  ? 133.640 175.201 153.968 1.00 78.64  ? 46  ARG D NH2 1 
ATOM 2841 N N   . ALA B 2 41  ? 139.739 172.389 157.014 1.00 74.58  ? 47  ALA D N   1 
ATOM 2842 C CA  . ALA B 2 41  ? 140.235 172.477 158.381 1.00 74.58  ? 47  ALA D CA  1 
ATOM 2843 C C   . ALA B 2 41  ? 139.795 173.810 158.975 1.00 74.58  ? 47  ALA D C   1 
ATOM 2844 O O   . ALA B 2 41  ? 138.966 174.523 158.401 1.00 74.58  ? 47  ALA D O   1 
ATOM 2845 C CB  . ALA B 2 41  ? 141.758 172.305 158.413 1.00 74.58  ? 47  ALA D CB  1 
ATOM 2846 N N   . HIS B 2 42  ? 140.351 174.143 160.136 1.00 67.03  ? 48  HIS D N   1 
ATOM 2847 C CA  . HIS B 2 42  ? 140.076 175.399 160.822 1.00 67.03  ? 48  HIS D CA  1 
ATOM 2848 C C   . HIS B 2 42  ? 141.313 176.280 160.749 1.00 67.03  ? 48  HIS D C   1 
ATOM 2849 O O   . HIS B 2 42  ? 142.439 175.785 160.868 1.00 67.03  ? 48  HIS D O   1 
ATOM 2850 C CB  . HIS B 2 42  ? 139.679 175.158 162.277 1.00 67.03  ? 48  HIS D CB  1 
ATOM 2851 C CG  . HIS B 2 42  ? 138.419 174.370 162.436 1.00 67.03  ? 48  HIS D CG  1 
ATOM 2852 N ND1 . HIS B 2 42  ? 138.413 173.044 162.809 1.00 67.03  ? 48  HIS D ND1 1 
ATOM 2853 C CD2 . HIS B 2 42  ? 137.122 174.723 162.281 1.00 67.03  ? 48  HIS D CD2 1 
ATOM 2854 C CE1 . HIS B 2 42  ? 137.166 172.613 162.871 1.00 67.03  ? 48  HIS D CE1 1 
ATOM 2855 N NE2 . HIS B 2 42  ? 136.363 173.613 162.555 1.00 67.03  ? 48  HIS D NE2 1 
ATOM 2856 N N   . ARG B 2 43  ? 141.101 177.581 160.545 1.00 69.91  ? 49  ARG D N   1 
ATOM 2857 C CA  . ARG B 2 43  ? 142.220 178.512 160.484 1.00 69.91  ? 49  ARG D CA  1 
ATOM 2858 C C   . ARG B 2 43  ? 142.964 178.582 161.810 1.00 69.91  ? 49  ARG D C   1 
ATOM 2859 O O   . ARG B 2 43  ? 144.199 178.538 161.836 1.00 69.91  ? 49  ARG D O   1 
ATOM 2860 C CB  . ARG B 2 43  ? 141.713 179.898 160.085 1.00 69.91  ? 49  ARG D CB  1 
ATOM 2861 C CG  . ARG B 2 43  ? 142.744 180.771 159.400 1.00 69.91  ? 49  ARG D CG  1 
ATOM 2862 C CD  . ARG B 2 43  ? 142.185 182.151 159.089 1.00 69.91  ? 49  ARG D CD  1 
ATOM 2863 N NE  . ARG B 2 43  ? 141.628 182.233 157.745 1.00 69.91  ? 49  ARG D NE  1 
ATOM 2864 C CZ  . ARG B 2 43  ? 140.334 182.161 157.467 1.00 69.91  ? 49  ARG D CZ  1 
ATOM 2865 N NH1 . ARG B 2 43  ? 139.431 182.007 158.420 1.00 69.91  ? 49  ARG D NH1 1 
ATOM 2866 N NH2 . ARG B 2 43  ? 139.936 182.247 156.201 1.00 69.91  ? 49  ARG D NH2 1 
ATOM 2867 N N   . SER B 2 44  ? 142.231 178.669 162.921 1.00 66.19  ? 50  SER D N   1 
ATOM 2868 C CA  . SER B 2 44  ? 142.858 178.813 164.231 1.00 66.19  ? 50  SER D CA  1 
ATOM 2869 C C   . SER B 2 44  ? 143.644 177.570 164.629 1.00 66.19  ? 50  SER D C   1 
ATOM 2870 O O   . SER B 2 44  ? 144.728 177.682 165.211 1.00 66.19  ? 50  SER D O   1 
ATOM 2871 C CB  . SER B 2 44  ? 141.798 179.124 165.286 1.00 66.19  ? 50  SER D CB  1 
ATOM 2872 O OG  . SER B 2 44  ? 141.233 177.934 165.805 1.00 66.19  ? 50  SER D OG  1 
ATOM 2873 N N   . VAL B 2 45  ? 143.113 176.381 164.336 1.00 61.77  ? 51  VAL D N   1 
ATOM 2874 C CA  . VAL B 2 45  ? 143.784 175.149 164.739 1.00 61.77  ? 51  VAL D CA  1 
ATOM 2875 C C   . VAL B 2 45  ? 145.138 175.028 164.054 1.00 61.77  ? 51  VAL D C   1 
ATOM 2876 O O   . VAL B 2 45  ? 146.157 174.766 164.705 1.00 61.77  ? 51  VAL D O   1 
ATOM 2877 C CB  . VAL B 2 45  ? 142.891 173.933 164.439 1.00 61.77  ? 51  VAL D CB  1 
ATOM 2878 C CG1 . VAL B 2 45  ? 143.665 172.647 164.644 1.00 61.77  ? 51  VAL D CG1 1 
ATOM 2879 C CG2 . VAL B 2 45  ? 141.653 173.959 165.313 1.00 61.77  ? 51  VAL D CG2 1 
ATOM 2880 N N   . LEU B 2 46  ? 145.178 175.229 162.740 1.00 66.41  ? 52  LEU D N   1 
ATOM 2881 C CA  . LEU B 2 46  ? 146.426 175.156 161.998 1.00 66.41  ? 52  LEU D CA  1 
ATOM 2882 C C   . LEU B 2 46  ? 147.320 176.365 162.222 1.00 66.41  ? 52  LEU D C   1 
ATOM 2883 O O   . LEU B 2 46  ? 148.522 176.284 161.949 1.00 66.41  ? 52  LEU D O   1 
ATOM 2884 C CB  . LEU B 2 46  ? 146.147 175.001 160.501 1.00 66.41  ? 52  LEU D CB  1 
ATOM 2885 C CG  . LEU B 2 46  ? 145.646 173.621 160.073 1.00 66.41  ? 52  LEU D CG  1 
ATOM 2886 C CD1 . LEU B 2 46  ? 145.137 173.660 158.645 1.00 66.41  ? 52  LEU D CD1 1 
ATOM 2887 C CD2 . LEU B 2 46  ? 146.740 172.579 160.229 1.00 66.41  ? 52  LEU D CD2 1 
ATOM 2888 N N   . ALA B 2 47  ? 146.776 177.472 162.718 1.00 70.85  ? 53  ALA D N   1 
ATOM 2889 C CA  . ALA B 2 47  ? 147.624 178.618 163.029 1.00 70.85  ? 53  ALA D CA  1 
ATOM 2890 C C   . ALA B 2 47  ? 148.530 178.375 164.212 1.00 70.85  ? 53  ALA D C   1 
ATOM 2891 O O   . ALA B 2 47  ? 149.452 179.168 164.432 1.00 70.85  ? 53  ALA D O   1 
ATOM 2892 C CB  . ALA B 2 47  ? 146.760 179.854 163.283 1.00 70.85  ? 53  ALA D CB  1 
ATOM 2893 N N   . ALA B 2 48  ? 148.311 177.309 164.980 1.00 68.05  ? 54  ALA D N   1 
ATOM 2894 C CA  . ALA B 2 48  ? 149.124 177.044 166.158 1.00 68.05  ? 54  ALA D CA  1 
ATOM 2895 C C   . ALA B 2 48  ? 149.660 175.620 166.153 1.00 68.05  ? 54  ALA D C   1 
ATOM 2896 O O   . ALA B 2 48  ? 150.687 175.339 166.778 1.00 68.05  ? 54  ALA D O   1 
ATOM 2897 C CB  . ALA B 2 48  ? 148.315 177.295 167.431 1.00 68.05  ? 54  ALA D CB  1 
ATOM 2898 N N   . CYS B 2 49  ? 148.974 174.712 165.456 1.00 70.00  ? 55  CYS D N   1 
ATOM 2899 C CA  . CYS B 2 49  ? 149.442 173.332 165.412 1.00 70.00  ? 55  CYS D CA  1 
ATOM 2900 C C   . CYS B 2 49  ? 150.759 173.208 164.659 1.00 70.00  ? 55  CYS D C   1 
ATOM 2901 O O   . CYS B 2 49  ? 151.644 172.456 165.082 1.00 70.00  ? 55  CYS D O   1 
ATOM 2902 C CB  . CYS B 2 49  ? 148.383 172.435 164.778 1.00 70.00  ? 55  CYS D CB  1 
ATOM 2903 S SG  . CYS B 2 49  ? 148.817 170.688 164.783 1.00 70.00  ? 55  CYS D SG  1 
ATOM 2904 N N   . SER B 2 50  ? 150.913 173.935 163.555 1.00 79.67  ? 56  SER D N   1 
ATOM 2905 C CA  . SER B 2 50  ? 152.130 173.927 162.765 1.00 79.67  ? 56  SER D CA  1 
ATOM 2906 C C   . SER B 2 50  ? 152.816 175.290 162.876 1.00 79.67  ? 56  SER D C   1 
ATOM 2907 O O   . SER B 2 50  ? 152.323 176.192 163.568 1.00 79.67  ? 56  SER D O   1 
ATOM 2908 C CB  . SER B 2 50  ? 151.793 173.548 161.322 1.00 79.67  ? 56  SER D CB  1 
ATOM 2909 O OG  . SER B 2 50  ? 152.891 172.911 160.694 1.00 79.67  ? 56  SER D OG  1 
ATOM 2910 N N   . SER B 2 51  ? 153.948 175.440 162.197 1.00 82.81  ? 57  SER D N   1 
ATOM 2911 C CA  . SER B 2 51  ? 154.686 176.698 162.222 1.00 82.81  ? 57  SER D CA  1 
ATOM 2912 C C   . SER B 2 51  ? 154.983 177.147 160.793 1.00 82.81  ? 57  SER D C   1 
ATOM 2913 O O   . SER B 2 51  ? 155.922 177.902 160.534 1.00 82.81  ? 57  SER D O   1 
ATOM 2914 C CB  . SER B 2 51  ? 155.964 176.566 163.049 1.00 82.81  ? 57  SER D CB  1 
ATOM 2915 O OG  . SER B 2 51  ? 156.316 177.806 163.637 1.00 82.81  ? 57  SER D OG  1 
ATOM 2916 N N   . TYR B 2 52  ? 154.176 176.678 159.844 1.00 90.75  ? 58  TYR D N   1 
ATOM 2917 C CA  . TYR B 2 52  ? 154.214 177.180 158.476 1.00 90.75  ? 58  TYR D CA  1 
ATOM 2918 C C   . TYR B 2 52  ? 152.833 177.731 158.154 1.00 90.75  ? 58  TYR D C   1 
ATOM 2919 O O   . TYR B 2 52  ? 152.687 178.714 157.414 1.00 90.75  ? 58  TYR D O   1 
ATOM 2920 C CB  . TYR B 2 52  ? 154.619 176.075 157.499 1.00 90.75  ? 58  TYR D CB  1 
ATOM 2921 C CG  . TYR B 2 52  ? 154.560 176.479 156.044 1.00 90.75  ? 58  TYR D CG  1 
ATOM 2922 C CD1 . TYR B 2 52  ? 155.351 177.510 155.558 1.00 90.75  ? 58  TYR D CD1 1 
ATOM 2923 C CD2 . TYR B 2 52  ? 153.723 175.821 155.153 1.00 90.75  ? 58  TYR D CD2 1 
ATOM 2924 C CE1 . TYR B 2 52  ? 155.305 177.879 154.229 1.00 90.75  ? 58  TYR D CE1 1 
ATOM 2925 C CE2 . TYR B 2 52  ? 153.670 176.183 153.823 1.00 90.75  ? 58  TYR D CE2 1 
ATOM 2926 C CZ  . TYR B 2 52  ? 154.463 177.212 153.367 1.00 90.75  ? 58  TYR D CZ  1 
ATOM 2927 O OH  . TYR B 2 52  ? 154.414 177.576 152.042 1.00 90.75  ? 58  TYR D OH  1 
ATOM 2928 N N   . PHE B 2 53  ? 151.818 177.111 158.743 1.00 84.12  ? 59  PHE D N   1 
ATOM 2929 C CA  . PHE B 2 53  ? 150.455 177.636 158.741 1.00 84.12  ? 59  PHE D CA  1 
ATOM 2930 C C   . PHE B 2 53  ? 150.290 178.689 159.829 1.00 84.12  ? 59  PHE D C   1 
ATOM 2931 O O   . PHE B 2 53  ? 149.186 179.012 160.258 1.00 84.12  ? 59  PHE D O   1 
ATOM 2932 C CB  . PHE B 2 53  ? 149.452 176.503 158.915 1.00 84.12  ? 59  PHE D CB  1 
ATOM 2933 C CG  . PHE B 2 53  ? 149.460 175.507 157.794 1.00 84.12  ? 59  PHE D CG  1 
ATOM 2934 C CD1 . PHE B 2 53  ? 149.239 175.910 156.491 1.00 84.12  ? 59  PHE D CD1 1 
ATOM 2935 C CD2 . PHE B 2 53  ? 149.679 174.165 158.046 1.00 84.12  ? 59  PHE D CD2 1 
ATOM 2936 C CE1 . PHE B 2 53  ? 149.242 174.994 155.459 1.00 84.12  ? 59  PHE D CE1 1 
ATOM 2937 C CE2 . PHE B 2 53  ? 149.680 173.244 157.020 1.00 84.12  ? 59  PHE D CE2 1 
ATOM 2938 C CZ  . PHE B 2 53  ? 149.463 173.659 155.725 1.00 84.12  ? 59  PHE D CZ  1 
ATOM 2939 N N   . HIS B 2 54  ? 151.419 179.206 160.317 1.00 90.58  ? 60  HIS D N   1 
ATOM 2940 C CA  . HIS B 2 54  ? 151.393 180.423 161.120 1.00 90.58  ? 60  HIS D CA  1 
ATOM 2941 C C   . HIS B 2 54  ? 152.096 181.566 160.399 1.00 90.58  ? 60  HIS D C   1 
ATOM 2942 O O   . HIS B 2 54  ? 151.990 182.714 160.848 1.00 90.58  ? 60  HIS D O   1 
ATOM 2943 C CB  . HIS B 2 54  ? 152.038 180.192 162.493 1.00 90.58  ? 60  HIS D CB  1 
ATOM 2944 C CG  . HIS B 2 54  ? 151.784 181.296 163.472 1.00 90.58  ? 60  HIS D CG  1 
ATOM 2945 N ND1 . HIS B 2 54  ? 152.606 181.538 164.552 1.00 90.58  ? 60  HIS D ND1 1 
ATOM 2946 C CD2 . HIS B 2 54  ? 150.799 182.223 163.535 1.00 90.58  ? 60  HIS D CD2 1 
ATOM 2947 C CE1 . HIS B 2 54  ? 152.139 182.566 165.236 1.00 90.58  ? 60  HIS D CE1 1 
ATOM 2948 N NE2 . HIS B 2 54  ? 151.044 183.001 164.640 1.00 90.58  ? 60  HIS D NE2 1 
ATOM 2949 N N   . SER B 2 55  ? 152.799 181.298 159.298 1.00 96.79  ? 61  SER D N   1 
ATOM 2950 C CA  . SER B 2 55  ? 153.369 182.345 158.463 1.00 96.79  ? 61  SER D CA  1 
ATOM 2951 C C   . SER B 2 55  ? 152.630 182.476 157.138 1.00 96.79  ? 61  SER D C   1 
ATOM 2952 O O   . SER B 2 55  ? 152.769 183.505 156.467 1.00 96.79  ? 61  SER D O   1 
ATOM 2953 C CB  . SER B 2 55  ? 154.859 182.086 158.210 1.00 96.79  ? 61  SER D CB  1 
ATOM 2954 O OG  . SER B 2 55  ? 155.639 182.452 159.334 1.00 96.79  ? 61  SER D OG  1 
ATOM 2955 N N   . ARG B 2 56  ? 151.844 181.472 156.748 1.00 101.42 ? 62  ARG D N   1 
ATOM 2956 C CA  . ARG B 2 56  ? 151.013 181.609 155.556 1.00 101.42 ? 62  ARG D CA  1 
ATOM 2957 C C   . ARG B 2 56  ? 149.533 181.669 155.911 1.00 101.42 ? 62  ARG D C   1 
ATOM 2958 O O   . ARG B 2 56  ? 148.674 181.406 155.064 1.00 101.42 ? 62  ARG D O   1 
ATOM 2959 C CB  . ARG B 2 56  ? 151.288 180.469 154.578 1.00 101.42 ? 62  ARG D CB  1 
ATOM 2960 C CG  . ARG B 2 56  ? 152.743 180.380 154.195 1.00 101.42 ? 62  ARG D CG  1 
ATOM 2961 C CD  . ARG B 2 56  ? 153.055 181.433 153.154 1.00 101.42 ? 62  ARG D CD  1 
ATOM 2962 N NE  . ARG B 2 56  ? 154.481 181.719 153.072 1.00 101.42 ? 62  ARG D NE  1 
ATOM 2963 C CZ  . ARG B 2 56  ? 155.101 182.121 151.973 1.00 101.42 ? 62  ARG D CZ  1 
ATOM 2964 N NH1 . ARG B 2 56  ? 154.455 182.263 150.827 1.00 101.42 ? 62  ARG D NH1 1 
ATOM 2965 N NH2 . ARG B 2 56  ? 156.400 182.396 152.026 1.00 101.42 ? 62  ARG D NH2 1 
ATOM 2966 N N   . ILE B 2 57  ? 149.231 182.023 157.156 1.00 93.04  ? 63  ILE D N   1 
ATOM 2967 C CA  . ILE B 2 57  ? 147.855 182.174 157.607 1.00 93.04  ? 63  ILE D CA  1 
ATOM 2968 C C   . ILE B 2 57  ? 147.582 183.549 158.213 1.00 93.04  ? 63  ILE D C   1 
ATOM 2969 O O   . ILE B 2 57  ? 146.435 184.020 158.147 1.00 93.04  ? 63  ILE D O   1 
ATOM 2970 C CB  . ILE B 2 57  ? 147.482 181.051 158.601 1.00 93.04  ? 63  ILE D CB  1 
ATOM 2971 C CG1 . ILE B 2 57  ? 147.340 179.717 157.865 1.00 93.04  ? 63  ILE D CG1 1 
ATOM 2972 C CG2 . ILE B 2 57  ? 146.212 181.357 159.362 1.00 93.04  ? 63  ILE D CG2 1 
ATOM 2973 C CD1 . ILE B 2 57  ? 146.460 179.783 156.636 1.00 93.04  ? 63  ILE D CD1 1 
ATOM 2974 N N   . VAL B 2 58  ? 148.597 184.237 158.731 1.00 98.07  ? 64  VAL D N   1 
ATOM 2975 C CA  . VAL B 2 58  ? 148.394 185.534 159.369 1.00 98.07  ? 64  VAL D CA  1 
ATOM 2976 C C   . VAL B 2 58  ? 148.573 186.631 158.329 1.00 98.07  ? 64  VAL D C   1 
ATOM 2977 O O   . VAL B 2 58  ? 149.141 186.399 157.256 1.00 98.07  ? 64  VAL D O   1 
ATOM 2978 C CB  . VAL B 2 58  ? 149.359 185.738 160.549 1.00 98.07  ? 64  VAL D CB  1 
ATOM 2979 C CG1 . VAL B 2 58  ? 149.093 184.711 161.634 1.00 98.07  ? 64  VAL D CG1 1 
ATOM 2980 C CG2 . VAL B 2 58  ? 150.797 185.668 160.072 1.00 98.07  ? 64  VAL D CG2 1 
ATOM 2981 N N   . GLY B 2 59  ? 148.090 187.828 158.641 1.00 104.21 ? 65  GLY D N   1 
ATOM 2982 C CA  . GLY B 2 59  ? 148.136 188.928 157.694 1.00 104.21 ? 65  GLY D CA  1 
ATOM 2983 C C   . GLY B 2 59  ? 147.251 188.731 156.483 1.00 104.21 ? 65  GLY D C   1 
ATOM 2984 O O   . GLY B 2 59  ? 147.641 189.098 155.368 1.00 104.21 ? 65  GLY D O   1 
ATOM 2985 N N   . GLN B 2 60  ? 146.066 188.162 156.676 1.00 101.85 ? 66  GLN D N   1 
ATOM 2986 C CA  . GLN B 2 60  ? 145.105 187.973 155.597 1.00 101.85 ? 66  GLN D CA  1 
ATOM 2987 C C   . GLN B 2 60  ? 143.786 188.605 156.037 1.00 101.85 ? 66  GLN D C   1 
ATOM 2988 O O   . GLN B 2 60  ? 143.695 189.279 157.071 1.00 101.85 ? 66  GLN D O   1 
ATOM 2989 C CB  . GLN B 2 60  ? 144.950 186.487 155.245 1.00 101.85 ? 66  GLN D CB  1 
ATOM 2990 C CG  . GLN B 2 60  ? 146.196 185.649 155.469 1.00 101.85 ? 66  GLN D CG  1 
ATOM 2991 C CD  . GLN B 2 60  ? 147.005 185.454 154.204 1.00 101.85 ? 66  GLN D CD  1 
ATOM 2992 O OE1 . GLN B 2 60  ? 146.492 184.973 153.193 1.00 101.85 ? 66  GLN D OE1 1 
ATOM 2993 N NE2 . GLN B 2 60  ? 148.279 185.825 154.252 1.00 101.85 ? 66  GLN D NE2 1 
ATOM 2994 N N   . ALA B 2 61  ? 142.737 188.393 155.245 1.00 98.07  ? 67  ALA D N   1 
ATOM 2995 C CA  . ALA B 2 61  ? 141.420 188.914 155.583 1.00 98.07  ? 67  ALA D CA  1 
ATOM 2996 C C   . ALA B 2 61  ? 140.490 187.776 155.976 1.00 98.07  ? 67  ALA D C   1 
ATOM 2997 O O   . ALA B 2 61  ? 140.907 186.614 156.016 1.00 98.07  ? 67  ALA D O   1 
ATOM 2998 C CB  . ALA B 2 61  ? 140.835 189.703 154.411 1.00 98.07  ? 67  ALA D CB  1 
ATOM 2999 N N   . ASP B 2 62  ? 139.231 188.094 156.269 1.00 104.04 ? 68  ASP D N   1 
ATOM 3000 C CA  . ASP B 2 62  ? 138.243 187.081 156.607 1.00 104.04 ? 68  ASP D CA  1 
ATOM 3001 C C   . ASP B 2 62  ? 137.812 186.260 155.403 1.00 104.04 ? 68  ASP D C   1 
ATOM 3002 O O   . ASP B 2 62  ? 137.230 185.184 155.581 1.00 104.04 ? 68  ASP D O   1 
ATOM 3003 C CB  . ASP B 2 62  ? 137.016 187.728 157.259 1.00 104.04 ? 68  ASP D CB  1 
ATOM 3004 C CG  . ASP B 2 62  ? 136.490 186.922 158.430 1.00 104.04 ? 68  ASP D CG  1 
ATOM 3005 O OD1 . ASP B 2 62  ? 136.268 185.705 158.263 1.00 104.04 ? 68  ASP D OD1 1 
ATOM 3006 O OD2 . ASP B 2 62  ? 136.303 187.504 159.519 1.00 104.04 ? 68  ASP D OD2 1 
ATOM 3007 N N   . GLY B 2 63  ? 138.074 186.736 154.188 1.00 99.90  ? 69  GLY D N   1 
ATOM 3008 C CA  . GLY B 2 63  ? 137.820 185.933 153.005 1.00 99.90  ? 69  GLY D CA  1 
ATOM 3009 C C   . GLY B 2 63  ? 138.656 184.665 153.028 1.00 99.90  ? 69  GLY D C   1 
ATOM 3010 O O   . GLY B 2 63  ? 139.848 184.685 153.332 1.00 99.90  ? 69  GLY D O   1 
ATOM 3011 N N   . GLU B 2 64  ? 138.006 183.547 152.711 1.00 101.59 ? 70  GLU D N   1 
ATOM 3012 C CA  . GLU B 2 64  ? 138.648 182.244 152.820 1.00 101.59 ? 70  GLU D CA  1 
ATOM 3013 C C   . GLU B 2 64  ? 139.895 182.175 151.949 1.00 101.59 ? 70  GLU D C   1 
ATOM 3014 O O   . GLU B 2 64  ? 139.847 182.451 150.747 1.00 101.59 ? 70  GLU D O   1 
ATOM 3015 C CB  . GLU B 2 64  ? 137.661 181.145 152.423 1.00 101.59 ? 70  GLU D CB  1 
ATOM 3016 C CG  . GLU B 2 64  ? 138.298 179.783 152.214 1.00 101.59 ? 70  GLU D CG  1 
ATOM 3017 C CD  . GLU B 2 64  ? 137.279 178.710 151.893 1.00 101.59 ? 70  GLU D CD  1 
ATOM 3018 O OE1 . GLU B 2 64  ? 136.455 178.391 152.775 1.00 101.59 ? 70  GLU D OE1 1 
ATOM 3019 O OE2 . GLU B 2 64  ? 137.302 178.186 150.759 1.00 101.59 ? 70  GLU D OE2 1 
ATOM 3020 N N   . LEU B 2 65  ? 141.013 181.804 152.565 1.00 89.45  ? 71  LEU D N   1 
ATOM 3021 C CA  . LEU B 2 65  ? 142.286 181.670 151.872 1.00 89.45  ? 71  LEU D CA  1 
ATOM 3022 C C   . LEU B 2 65  ? 142.478 180.218 151.461 1.00 89.45  ? 71  LEU D C   1 
ATOM 3023 O O   . LEU B 2 65  ? 142.334 179.310 152.286 1.00 89.45  ? 71  LEU D O   1 
ATOM 3024 C CB  . LEU B 2 65  ? 143.457 182.123 152.748 1.00 89.45  ? 71  LEU D CB  1 
ATOM 3025 C CG  . LEU B 2 65  ? 143.483 183.519 153.387 1.00 89.45  ? 71  LEU D CG  1 
ATOM 3026 C CD1 . LEU B 2 65  ? 143.186 184.607 152.358 1.00 89.45  ? 71  LEU D CD1 1 
ATOM 3027 C CD2 . LEU B 2 65  ? 142.576 183.637 154.611 1.00 89.45  ? 71  LEU D CD2 1 
ATOM 3028 N N   . ASN B 2 66  ? 142.802 180.003 150.190 1.00 86.21  ? 72  ASN D N   1 
ATOM 3029 C CA  . ASN B 2 66  ? 143.024 178.670 149.644 1.00 86.21  ? 72  ASN D CA  1 
ATOM 3030 C C   . ASN B 2 66  ? 144.519 178.487 149.413 1.00 86.21  ? 72  ASN D C   1 
ATOM 3031 O O   . ASN B 2 66  ? 145.028 178.800 148.332 1.00 86.21  ? 72  ASN D O   1 
ATOM 3032 C CB  . ASN B 2 66  ? 142.237 178.472 148.351 1.00 86.21  ? 72  ASN D CB  1 
ATOM 3033 C CG  . ASN B 2 66  ? 140.810 178.963 148.460 1.00 86.21  ? 72  ASN D CG  1 
ATOM 3034 O OD1 . ASN B 2 66  ? 140.265 179.083 149.557 1.00 86.21  ? 72  ASN D OD1 1 
ATOM 3035 N ND2 . ASN B 2 66  ? 140.194 179.250 147.320 1.00 86.21  ? 72  ASN D ND2 1 
ATOM 3036 N N   . ILE B 2 67  ? 145.215 177.983 150.425 1.00 81.00  ? 73  ILE D N   1 
ATOM 3037 C CA  . ILE B 2 67  ? 146.648 177.755 150.326 1.00 81.00  ? 73  ILE D CA  1 
ATOM 3038 C C   . ILE B 2 67  ? 146.897 176.394 149.685 1.00 81.00  ? 73  ILE D C   1 
ATOM 3039 O O   . ILE B 2 67  ? 146.121 175.448 149.841 1.00 81.00  ? 73  ILE D O   1 
ATOM 3040 C CB  . ILE B 2 67  ? 147.336 177.871 151.704 1.00 81.00  ? 73  ILE D CB  1 
ATOM 3041 C CG1 . ILE B 2 67  ? 148.838 178.113 151.536 1.00 81.00  ? 73  ILE D CG1 1 
ATOM 3042 C CG2 . ILE B 2 67  ? 147.072 176.639 152.554 1.00 81.00  ? 73  ILE D CG2 1 
ATOM 3043 C CD1 . ILE B 2 67  ? 149.172 179.366 150.756 1.00 81.00  ? 73  ILE D CD1 1 
ATOM 3044 N N   . THR B 2 68  ? 147.989 176.304 148.927 1.00 72.80  ? 74  THR D N   1 
ATOM 3045 C CA  . THR B 2 68  ? 148.351 175.086 148.216 1.00 72.80  ? 74  THR D CA  1 
ATOM 3046 C C   . THR B 2 68  ? 149.766 174.679 148.595 1.00 72.80  ? 74  THR D C   1 
ATOM 3047 O O   . THR B 2 68  ? 150.627 175.535 148.818 1.00 72.80  ? 74  THR D O   1 
ATOM 3048 C CB  . THR B 2 68  ? 148.260 175.267 146.696 1.00 72.80  ? 74  THR D CB  1 
ATOM 3049 O OG1 . THR B 2 68  ? 149.464 175.875 146.215 1.00 72.80  ? 74  THR D OG1 1 
ATOM 3050 C CG2 . THR B 2 68  ? 147.075 176.142 146.326 1.00 72.80  ? 74  THR D CG2 1 
ATOM 3051 N N   . LEU B 2 69  ? 150.000 173.372 148.666 1.00 72.56  ? 75  LEU D N   1 
ATOM 3052 C CA  . LEU B 2 69  ? 151.312 172.835 148.984 1.00 72.56  ? 75  LEU D CA  1 
ATOM 3053 C C   . LEU B 2 69  ? 151.955 172.213 147.754 1.00 72.56  ? 75  LEU D C   1 
ATOM 3054 O O   . LEU B 2 69  ? 151.280 171.588 146.932 1.00 72.56  ? 75  LEU D O   1 
ATOM 3055 C CB  . LEU B 2 69  ? 151.210 171.791 150.101 1.00 72.56  ? 75  LEU D CB  1 
ATOM 3056 C CG  . LEU B 2 69  ? 151.305 172.283 151.549 1.00 72.56  ? 75  LEU D CG  1 
ATOM 3057 C CD1 . LEU B 2 69  ? 150.305 173.387 151.847 1.00 72.56  ? 75  LEU D CD1 1 
ATOM 3058 C CD2 . LEU B 2 69  ? 151.126 171.128 152.517 1.00 72.56  ? 75  LEU D CD2 1 
ATOM 3059 N N   . PRO B 2 70  ? 153.271 172.374 147.595 1.00 81.57  ? 76  PRO D N   1 
ATOM 3060 C CA  . PRO B 2 70  ? 153.953 171.811 146.419 1.00 81.57  ? 76  PRO D CA  1 
ATOM 3061 C C   . PRO B 2 70  ? 153.915 170.291 146.366 1.00 81.57  ? 76  PRO D C   1 
ATOM 3062 O O   . PRO B 2 70  ? 153.416 169.635 147.285 1.00 81.57  ? 76  PRO D O   1 
ATOM 3063 C CB  . PRO B 2 70  ? 155.397 172.316 146.562 1.00 81.57  ? 76  PRO D CB  1 
ATOM 3064 C CG  . PRO B 2 70  ? 155.470 173.047 147.868 1.00 81.57  ? 76  PRO D CG  1 
ATOM 3065 C CD  . PRO B 2 70  ? 154.087 173.380 148.291 1.00 81.57  ? 76  PRO D CD  1 
ATOM 3066 N N   . GLU B 2 71  ? 154.457 169.724 145.288 1.00 87.38  ? 77  GLU D N   1 
ATOM 3067 C CA  . GLU B 2 71  ? 154.476 168.284 145.075 1.00 87.38  ? 77  GLU D CA  1 
ATOM 3068 C C   . GLU B 2 71  ? 155.463 167.570 145.990 1.00 87.38  ? 77  GLU D C   1 
ATOM 3069 O O   . GLU B 2 71  ? 155.462 166.336 146.048 1.00 87.38  ? 77  GLU D O   1 
ATOM 3070 C CB  . GLU B 2 71  ? 154.798 167.970 143.613 1.00 87.38  ? 77  GLU D CB  1 
ATOM 3071 C CG  . GLU B 2 71  ? 153.592 167.583 142.774 1.00 87.38  ? 77  GLU D CG  1 
ATOM 3072 C CD  . GLU B 2 71  ? 152.546 168.678 142.714 1.00 87.38  ? 77  GLU D CD  1 
ATOM 3073 O OE1 . GLU B 2 71  ? 152.872 169.787 142.239 1.00 87.38  ? 77  GLU D OE1 1 
ATOM 3074 O OE2 . GLU B 2 71  ? 151.398 168.430 143.138 1.00 87.38  ? 77  GLU D OE2 1 
ATOM 3075 N N   . GLU B 2 72  ? 156.308 168.319 146.699 1.00 84.73  ? 78  GLU D N   1 
ATOM 3076 C CA  . GLU B 2 72  ? 157.278 167.698 147.595 1.00 84.73  ? 78  GLU D CA  1 
ATOM 3077 C C   . GLU B 2 72  ? 156.575 166.982 148.744 1.00 84.73  ? 78  GLU D C   1 
ATOM 3078 O O   . GLU B 2 72  ? 157.063 165.968 149.255 1.00 84.73  ? 78  GLU D O   1 
ATOM 3079 C CB  . GLU B 2 72  ? 158.267 168.754 148.099 1.00 84.73  ? 78  GLU D CB  1 
ATOM 3080 C CG  . GLU B 2 72  ? 158.981 168.412 149.392 1.00 84.73  ? 78  GLU D CG  1 
ATOM 3081 C CD  . GLU B 2 72  ? 159.219 169.629 150.258 1.00 84.73  ? 78  GLU D CD  1 
ATOM 3082 O OE1 . GLU B 2 72  ? 160.008 169.534 151.222 1.00 84.73  ? 78  GLU D OE1 1 
ATOM 3083 O OE2 . GLU B 2 72  ? 158.634 170.688 149.957 1.00 84.73  ? 78  GLU D OE2 1 
ATOM 3084 N N   . VAL B 2 73  ? 155.413 167.489 149.155 1.00 77.21  ? 79  VAL D N   1 
ATOM 3085 C CA  . VAL B 2 73  ? 154.542 166.750 150.061 1.00 77.21  ? 79  VAL D CA  1 
ATOM 3086 C C   . VAL B 2 73  ? 153.436 166.118 149.227 1.00 77.21  ? 79  VAL D C   1 
ATOM 3087 O O   . VAL B 2 73  ? 153.096 166.617 148.148 1.00 77.21  ? 79  VAL D O   1 
ATOM 3088 C CB  . VAL B 2 73  ? 153.968 167.652 151.168 1.00 77.21  ? 79  VAL D CB  1 
ATOM 3089 C CG1 . VAL B 2 73  ? 155.069 168.487 151.792 1.00 77.21  ? 79  VAL D CG1 1 
ATOM 3090 C CG2 . VAL B 2 73  ? 152.871 168.541 150.617 1.00 77.21  ? 79  VAL D CG2 1 
ATOM 3091 N N   . THR B 2 74  ? 152.878 165.013 149.706 1.00 74.20  ? 80  THR D N   1 
ATOM 3092 C CA  . THR B 2 74  ? 151.845 164.303 148.962 1.00 74.20  ? 80  THR D CA  1 
ATOM 3093 C C   . THR B 2 74  ? 150.643 164.107 149.881 1.00 74.20  ? 80  THR D C   1 
ATOM 3094 O O   . THR B 2 74  ? 150.604 164.649 150.991 1.00 74.20  ? 80  THR D O   1 
ATOM 3095 C CB  . THR B 2 74  ? 152.377 162.967 148.415 1.00 74.20  ? 80  THR D CB  1 
ATOM 3096 O OG1 . THR B 2 74  ? 152.189 161.938 149.395 1.00 74.20  ? 80  THR D OG1 1 
ATOM 3097 C CG2 . THR B 2 74  ? 153.851 163.066 148.054 1.00 74.20  ? 80  THR D CG2 1 
ATOM 3098 N N   . VAL B 2 75  ? 149.661 163.336 149.416 1.00 68.54  ? 81  VAL D N   1 
ATOM 3099 C CA  . VAL B 2 75  ? 148.479 163.040 150.214 1.00 68.54  ? 81  VAL D CA  1 
ATOM 3100 C C   . VAL B 2 75  ? 148.671 161.805 151.090 1.00 68.54  ? 81  VAL D C   1 
ATOM 3101 O O   . VAL B 2 75  ? 147.904 161.614 152.047 1.00 68.54  ? 81  VAL D O   1 
ATOM 3102 C CB  . VAL B 2 75  ? 147.240 162.867 149.310 1.00 68.54  ? 81  VAL D CB  1 
ATOM 3103 C CG1 . VAL B 2 75  ? 147.315 161.552 148.546 1.00 68.54  ? 81  VAL D CG1 1 
ATOM 3104 C CG2 . VAL B 2 75  ? 145.953 162.972 150.118 1.00 68.54  ? 81  VAL D CG2 1 
ATOM 3105 N N   . LYS B 2 76  ? 149.671 160.972 150.805 1.00 64.50  ? 82  LYS D N   1 
ATOM 3106 C CA  . LYS B 2 76  ? 149.962 159.806 151.628 1.00 64.50  ? 82  LYS D CA  1 
ATOM 3107 C C   . LYS B 2 76  ? 150.599 160.174 152.952 1.00 64.50  ? 82  LYS D C   1 
ATOM 3108 O O   . LYS B 2 76  ? 150.573 159.372 153.888 1.00 64.50  ? 82  LYS D O   1 
ATOM 3109 C CB  . LYS B 2 76  ? 150.871 158.836 150.870 1.00 64.50  ? 82  LYS D CB  1 
ATOM 3110 C CG  . LYS B 2 76  ? 150.836 157.412 151.399 1.00 64.50  ? 82  LYS D CG  1 
ATOM 3111 C CD  . LYS B 2 76  ? 150.869 156.403 150.262 1.00 64.50  ? 82  LYS D CD  1 
ATOM 3112 C CE  . LYS B 2 76  ? 152.034 156.662 149.318 1.00 64.50  ? 82  LYS D CE  1 
ATOM 3113 N NZ  . LYS B 2 76  ? 152.030 155.738 148.146 1.00 64.50  ? 82  LYS D NZ  1 
ATOM 3114 N N   . GLY B 2 77  ? 151.155 161.374 153.060 1.00 64.52  ? 83  GLY D N   1 
ATOM 3115 C CA  . GLY B 2 77  ? 151.794 161.794 154.287 1.00 64.52  ? 83  GLY D CA  1 
ATOM 3116 C C   . GLY B 2 77  ? 151.020 162.848 155.046 1.00 64.52  ? 83  GLY D C   1 
ATOM 3117 O O   . GLY B 2 77  ? 151.273 163.068 156.234 1.00 64.52  ? 83  GLY D O   1 
ATOM 3118 N N   . PHE B 2 78  ? 150.085 163.518 154.369 1.00 62.40  ? 84  PHE D N   1 
ATOM 3119 C CA  . PHE B 2 78  ? 149.296 164.554 155.023 1.00 62.40  ? 84  PHE D CA  1 
ATOM 3120 C C   . PHE B 2 78  ? 148.100 163.999 155.781 1.00 62.40  ? 84  PHE D C   1 
ATOM 3121 O O   . PHE B 2 78  ? 147.835 164.447 156.900 1.00 62.40  ? 84  PHE D O   1 
ATOM 3122 C CB  . PHE B 2 78  ? 148.809 165.575 154.001 1.00 62.40  ? 84  PHE D CB  1 
ATOM 3123 C CG  . PHE B 2 78  ? 148.924 166.987 154.463 1.00 62.40  ? 84  PHE D CG  1 
ATOM 3124 C CD1 . PHE B 2 78  ? 150.157 167.549 154.726 1.00 62.40  ? 84  PHE D CD1 1 
ATOM 3125 C CD2 . PHE B 2 78  ? 147.788 167.740 154.681 1.00 62.40  ? 84  PHE D CD2 1 
ATOM 3126 C CE1 . PHE B 2 78  ? 150.254 168.852 155.161 1.00 62.40  ? 84  PHE D CE1 1 
ATOM 3127 C CE2 . PHE B 2 78  ? 147.884 169.034 155.123 1.00 62.40  ? 84  PHE D CE2 1 
ATOM 3128 C CZ  . PHE B 2 78  ? 149.111 169.592 155.361 1.00 62.40  ? 84  PHE D CZ  1 
ATOM 3129 N N   . GLU B 2 79  ? 147.367 163.054 155.200 1.00 60.79  ? 85  GLU D N   1 
ATOM 3130 C CA  . GLU B 2 79  ? 146.166 162.554 155.866 1.00 60.79  ? 85  GLU D CA  1 
ATOM 3131 C C   . GLU B 2 79  ? 146.478 161.960 157.233 1.00 60.79  ? 85  GLU D C   1 
ATOM 3132 O O   . GLU B 2 79  ? 145.746 162.261 158.188 1.00 60.79  ? 85  GLU D O   1 
ATOM 3133 C CB  . GLU B 2 79  ? 145.443 161.557 154.952 1.00 60.79  ? 85  GLU D CB  1 
ATOM 3134 C CG  . GLU B 2 79  ? 144.425 160.617 155.619 1.00 60.79  ? 85  GLU D CG  1 
ATOM 3135 C CD  . GLU B 2 79  ? 143.420 161.295 156.555 1.00 60.79  ? 85  GLU D CD  1 
ATOM 3136 O OE1 . GLU B 2 79  ? 143.316 162.537 156.589 1.00 60.79  ? 85  GLU D OE1 1 
ATOM 3137 O OE2 . GLU B 2 79  ? 142.714 160.552 157.280 1.00 60.79  ? 85  GLU D OE2 1 
ATOM 3138 N N   . PRO B 2 80  ? 147.508 161.131 157.407 1.00 56.12  ? 86  PRO D N   1 
ATOM 3139 C CA  . PRO B 2 80  ? 148.002 160.828 158.723 1.00 56.12  ? 86  PRO D CA  1 
ATOM 3140 C C   . PRO B 2 80  ? 148.337 162.036 159.580 1.00 56.12  ? 86  PRO D C   1 
ATOM 3141 O O   . PRO B 2 80  ? 148.072 162.001 160.781 1.00 56.12  ? 86  PRO D O   1 
ATOM 3142 C CB  . PRO B 2 80  ? 149.272 160.092 158.301 1.00 56.12  ? 86  PRO D CB  1 
ATOM 3143 C CG  . PRO B 2 80  ? 148.717 159.872 156.773 1.00 56.12  ? 86  PRO D CG  1 
ATOM 3144 C CD  . PRO B 2 80  ? 147.585 159.668 156.895 1.00 56.12  ? 86  PRO D CD  1 
ATOM 3145 N N   . LEU B 2 81  ? 148.904 163.090 159.009 1.00 49.60  ? 87  LEU D N   1 
ATOM 3146 C CA  . LEU B 2 81  ? 149.396 164.213 159.795 1.00 49.60  ? 87  LEU D CA  1 
ATOM 3147 C C   . LEU B 2 81  ? 148.286 165.163 160.226 1.00 49.60  ? 87  LEU D C   1 
ATOM 3148 O O   . LEU B 2 81  ? 148.249 165.586 161.384 1.00 49.60  ? 87  LEU D O   1 
ATOM 3149 C CB  . LEU B 2 81  ? 150.458 164.978 158.999 1.00 49.60  ? 87  LEU D CB  1 
ATOM 3150 C CG  . LEU B 2 81  ? 151.443 165.794 159.822 1.00 49.60  ? 87  LEU D CG  1 
ATOM 3151 C CD1 . LEU B 2 81  ? 152.384 164.867 160.568 1.00 49.60  ? 87  LEU D CD1 1 
ATOM 3152 C CD2 . LEU B 2 81  ? 152.216 166.725 158.919 1.00 49.60  ? 87  LEU D CD2 1 
ATOM 3153 N N   . ILE B 2 82  ? 147.369 165.507 159.321 1.00 51.06  ? 88  ILE D N   1 
ATOM 3154 C CA  . ILE B 2 82  ? 146.289 166.413 159.686 1.00 51.06  ? 88  ILE D CA  1 
ATOM 3155 C C   . ILE B 2 82  ? 145.281 165.760 160.615 1.00 51.06  ? 88  ILE D C   1 
ATOM 3156 O O   . ILE B 2 82  ? 144.604 166.464 161.372 1.00 51.06  ? 88  ILE D O   1 
ATOM 3157 C CB  . ILE B 2 82  ? 145.576 166.972 158.438 1.00 51.06  ? 88  ILE D CB  1 
ATOM 3158 C CG1 . ILE B 2 82  ? 144.985 168.339 158.759 1.00 51.06  ? 88  ILE D CG1 1 
ATOM 3159 C CG2 . ILE B 2 82  ? 144.478 166.036 157.959 1.00 51.06  ? 88  ILE D CG2 1 
ATOM 3160 C CD1 . ILE B 2 82  ? 144.175 168.936 157.646 1.00 51.06  ? 88  ILE D CD1 1 
ATOM 3161 N N   . GLN B 2 83  ? 145.173 164.431 160.596 1.00 49.95  ? 89  GLN D N   1 
ATOM 3162 C CA  . GLN B 2 83  ? 144.339 163.711 161.546 1.00 49.95  ? 89  GLN D CA  1 
ATOM 3163 C C   . GLN B 2 83  ? 144.956 163.693 162.940 1.00 49.95  ? 89  GLN D C   1 
ATOM 3164 O O   . GLN B 2 83  ? 144.232 163.781 163.937 1.00 49.95  ? 89  GLN D O   1 
ATOM 3165 C CB  . GLN B 2 83  ? 144.083 162.292 161.040 1.00 49.95  ? 89  GLN D CB  1 
ATOM 3166 C CG  . GLN B 2 83  ? 143.671 161.304 162.104 1.00 49.95  ? 89  GLN D CG  1 
ATOM 3167 C CD  . GLN B 2 83  ? 143.523 159.899 161.565 1.00 49.95  ? 89  GLN D CD  1 
ATOM 3168 O OE1 . GLN B 2 83  ? 143.162 159.694 160.408 1.00 49.95  ? 89  GLN D OE1 1 
ATOM 3169 N NE2 . GLN B 2 83  ? 143.807 158.915 162.410 1.00 49.95  ? 89  GLN D NE2 1 
ATOM 3170 N N   . PHE B 2 84  ? 146.283 163.614 163.026 1.00 49.31  ? 90  PHE D N   1 
ATOM 3171 C CA  . PHE B 2 84  ? 146.987 163.835 164.277 1.00 49.31  ? 90  PHE D CA  1 
ATOM 3172 C C   . PHE B 2 84  ? 146.918 165.278 164.745 1.00 49.31  ? 90  PHE D C   1 
ATOM 3173 O O   . PHE B 2 84  ? 146.915 165.519 165.957 1.00 49.31  ? 90  PHE D O   1 
ATOM 3174 C CB  . PHE B 2 84  ? 148.460 163.419 164.146 1.00 49.31  ? 90  PHE D CB  1 
ATOM 3175 C CG  . PHE B 2 84  ? 149.317 163.871 165.287 1.00 49.31  ? 90  PHE D CG  1 
ATOM 3176 C CD1 . PHE B 2 84  ? 149.290 163.205 166.495 1.00 49.31  ? 90  PHE D CD1 1 
ATOM 3177 C CD2 . PHE B 2 84  ? 150.145 164.969 165.150 1.00 49.31  ? 90  PHE D CD2 1 
ATOM 3178 C CE1 . PHE B 2 84  ? 150.074 163.624 167.544 1.00 49.31  ? 90  PHE D CE1 1 
ATOM 3179 C CE2 . PHE B 2 84  ? 150.931 165.391 166.193 1.00 49.31  ? 90  PHE D CE2 1 
ATOM 3180 C CZ  . PHE B 2 84  ? 150.896 164.718 167.392 1.00 49.31  ? 90  PHE D CZ  1 
ATOM 3181 N N   . ALA B 2 85  ? 146.846 166.233 163.826 1.00 46.93  ? 91  ALA D N   1 
ATOM 3182 C CA  . ALA B 2 85  ? 146.686 167.640 164.161 1.00 46.93  ? 91  ALA D CA  1 
ATOM 3183 C C   . ALA B 2 85  ? 145.341 167.939 164.805 1.00 46.93  ? 91  ALA D C   1 
ATOM 3184 O O   . ALA B 2 85  ? 145.152 169.043 165.326 1.00 46.93  ? 91  ALA D O   1 
ATOM 3185 C CB  . ALA B 2 85  ? 146.855 168.501 162.906 1.00 46.93  ? 91  ALA D CB  1 
ATOM 3186 N N   . TYR B 2 86  ? 144.406 166.990 164.777 1.00 53.97  ? 92  TYR D N   1 
ATOM 3187 C CA  . TYR B 2 86  ? 143.090 167.196 165.360 1.00 53.97  ? 92  TYR D CA  1 
ATOM 3188 C C   . TYR B 2 86  ? 142.720 166.166 166.419 1.00 53.97  ? 92  TYR D C   1 
ATOM 3189 O O   . TYR B 2 86  ? 141.854 166.455 167.250 1.00 53.97  ? 92  TYR D O   1 
ATOM 3190 C CB  . TYR B 2 86  ? 142.019 167.191 164.260 1.00 53.97  ? 92  TYR D CB  1 
ATOM 3191 C CG  . TYR B 2 86  ? 141.770 168.544 163.641 1.00 53.97  ? 92  TYR D CG  1 
ATOM 3192 C CD1 . TYR B 2 86  ? 140.920 169.457 164.241 1.00 53.97  ? 92  TYR D CD1 1 
ATOM 3193 C CD2 . TYR B 2 86  ? 142.385 168.906 162.453 1.00 53.97  ? 92  TYR D CD2 1 
ATOM 3194 C CE1 . TYR B 2 86  ? 140.691 170.694 163.678 1.00 53.97  ? 92  TYR D CE1 1 
ATOM 3195 C CE2 . TYR B 2 86  ? 142.162 170.139 161.882 1.00 53.97  ? 92  TYR D CE2 1 
ATOM 3196 C CZ  . TYR B 2 86  ? 141.315 171.030 162.498 1.00 53.97  ? 92  TYR D CZ  1 
ATOM 3197 O OH  . TYR B 2 86  ? 141.090 172.261 161.930 1.00 53.97  ? 92  TYR D OH  1 
ATOM 3198 N N   . THR B 2 87  ? 143.337 164.983 166.424 1.00 50.04  ? 93  THR D N   1 
ATOM 3199 C CA  . THR B 2 87  ? 142.961 163.939 167.370 1.00 50.04  ? 93  THR D CA  1 
ATOM 3200 C C   . THR B 2 87  ? 144.129 163.518 168.251 1.00 50.04  ? 93  THR D C   1 
ATOM 3201 O O   . THR B 2 87  ? 143.958 162.695 169.156 1.00 50.04  ? 93  THR D O   1 
ATOM 3202 C CB  . THR B 2 87  ? 142.415 162.712 166.637 1.00 50.04  ? 93  THR D CB  1 
ATOM 3203 O OG1 . THR B 2 87  ? 143.505 161.943 166.114 1.00 50.04  ? 93  THR D OG1 1 
ATOM 3204 C CG2 . THR B 2 87  ? 141.507 163.126 165.500 1.00 50.04  ? 93  THR D CG2 1 
ATOM 3205 N N   . ALA B 2 88  ? 145.312 164.073 167.995 1.00 49.55  ? 94  ALA D N   1 
ATOM 3206 C CA  . ALA B 2 88  ? 146.529 163.734 168.732 1.00 49.55  ? 94  ALA D CA  1 
ATOM 3207 C C   . ALA B 2 88  ? 146.798 162.230 168.697 1.00 49.55  ? 94  ALA D C   1 
ATOM 3208 O O   . ALA B 2 88  ? 147.145 161.608 169.702 1.00 49.55  ? 94  ALA D O   1 
ATOM 3209 C CB  . ALA B 2 88  ? 146.460 164.247 170.171 1.00 49.55  ? 94  ALA D CB  1 
ATOM 3210 N N   . LYS B 2 89  ? 146.629 161.643 167.513 1.00 51.12  ? 95  LYS D N   1 
ATOM 3211 C CA  . LYS B 2 89  ? 146.919 160.231 167.295 1.00 51.12  ? 95  LYS D CA  1 
ATOM 3212 C C   . LYS B 2 89  ? 147.306 160.010 165.839 1.00 51.12  ? 95  LYS D C   1 
ATOM 3213 O O   . LYS B 2 89  ? 146.505 160.258 164.933 1.00 51.12  ? 95  LYS D O   1 
ATOM 3214 C CB  . LYS B 2 89  ? 145.719 159.364 167.676 1.00 51.12  ? 95  LYS D CB  1 
ATOM 3215 C CG  . LYS B 2 89  ? 145.707 157.995 167.019 1.00 51.12  ? 95  LYS D CG  1 
ATOM 3216 C CD  . LYS B 2 89  ? 144.579 157.135 167.562 1.00 51.12  ? 95  LYS D CD  1 
ATOM 3217 C CE  . LYS B 2 89  ? 144.935 155.659 167.514 1.00 51.12  ? 95  LYS D CE  1 
ATOM 3218 N NZ  . LYS B 2 89  ? 144.039 154.839 168.372 1.00 51.12  ? 95  LYS D NZ  1 
ATOM 3219 N N   . LEU B 2 90  ? 148.530 159.548 165.604 1.00 54.69  ? 96  LEU D N   1 
ATOM 3220 C CA  . LEU B 2 90  ? 149.112 159.481 164.265 1.00 54.69  ? 96  LEU D CA  1 
ATOM 3221 C C   . LEU B 2 90  ? 149.415 158.020 163.938 1.00 54.69  ? 96  LEU D C   1 
ATOM 3222 O O   . LEU B 2 90  ? 150.364 157.440 164.473 1.00 54.69  ? 96  LEU D O   1 
ATOM 3223 C CB  . LEU B 2 90  ? 150.357 160.361 164.192 1.00 54.69  ? 96  LEU D CB  1 
ATOM 3224 C CG  . LEU B 2 90  ? 151.246 160.368 162.953 1.00 54.69  ? 96  LEU D CG  1 
ATOM 3225 C CD1 . LEU B 2 90  ? 151.694 161.781 162.666 1.00 54.69  ? 96  LEU D CD1 1 
ATOM 3226 C CD2 . LEU B 2 90  ? 152.453 159.498 163.186 1.00 54.69  ? 96  LEU D CD2 1 
ATOM 3227 N N   . ILE B 2 91  ? 148.602 157.429 163.065 1.00 55.27  ? 97  ILE D N   1 
ATOM 3228 C CA  . ILE B 2 91  ? 148.757 156.030 162.674 1.00 55.27  ? 97  ILE D CA  1 
ATOM 3229 C C   . ILE B 2 91  ? 149.947 155.923 161.726 1.00 55.27  ? 97  ILE D C   1 
ATOM 3230 O O   . ILE B 2 91  ? 150.130 156.771 160.848 1.00 55.27  ? 97  ILE D O   1 
ATOM 3231 C CB  . ILE B 2 91  ? 147.480 155.483 162.026 1.00 55.27  ? 97  ILE D CB  1 
ATOM 3232 C CG1 . ILE B 2 91  ? 146.306 155.580 162.996 1.00 55.27  ? 97  ILE D CG1 1 
ATOM 3233 C CG2 . ILE B 2 91  ? 147.670 154.043 161.592 1.00 55.27  ? 97  ILE D CG2 1 
ATOM 3234 C CD1 . ILE B 2 91  ? 146.622 155.069 164.378 1.00 55.27  ? 97  ILE D CD1 1 
ATOM 3235 N N   . LEU B 2 92  ? 150.759 154.885 161.900 1.00 68.46  ? 98  LEU D N   1 
ATOM 3236 C CA  . LEU B 2 92  ? 151.911 154.637 161.048 1.00 68.46  ? 98  LEU D CA  1 
ATOM 3237 C C   . LEU B 2 92  ? 151.821 153.261 160.399 1.00 68.46  ? 98  LEU D C   1 
ATOM 3238 O O   . LEU B 2 92  ? 151.319 152.303 160.991 1.00 68.46  ? 98  LEU D O   1 
ATOM 3239 C CB  . LEU B 2 92  ? 153.208 154.756 161.847 1.00 68.46  ? 98  LEU D CB  1 
ATOM 3240 C CG  . LEU B 2 92  ? 153.650 156.196 162.086 1.00 68.46  ? 98  LEU D CG  1 
ATOM 3241 C CD1 . LEU B 2 92  ? 155.124 156.266 162.418 1.00 68.46  ? 98  LEU D CD1 1 
ATOM 3242 C CD2 . LEU B 2 92  ? 153.355 157.016 160.852 1.00 68.46  ? 98  LEU D CD2 1 
ATOM 3243 N N   . SER B 2 93  ? 152.317 153.176 159.168 1.00 78.57  ? 99  SER D N   1 
ATOM 3244 C CA  . SER B 2 93  ? 152.304 151.938 158.400 1.00 78.57  ? 99  SER D CA  1 
ATOM 3245 C C   . SER B 2 93  ? 153.569 151.896 157.552 1.00 78.57  ? 99  SER D C   1 
ATOM 3246 O O   . SER B 2 93  ? 154.354 152.847 157.530 1.00 78.57  ? 99  SER D O   1 
ATOM 3247 C CB  . SER B 2 93  ? 151.042 151.830 157.542 1.00 78.57  ? 99  SER D CB  1 
ATOM 3248 O OG  . SER B 2 93  ? 151.236 152.434 156.275 1.00 78.57  ? 99  SER D OG  1 
ATOM 3249 N N   . LYS B 2 94  ? 153.758 150.779 156.848 1.00 77.61  ? 100 LYS D N   1 
ATOM 3250 C CA  . LYS B 2 94  ? 154.978 150.531 156.087 1.00 77.61  ? 100 LYS D CA  1 
ATOM 3251 C C   . LYS B 2 94  ? 155.282 151.641 155.089 1.00 77.61  ? 100 LYS D C   1 
ATOM 3252 O O   . LYS B 2 94  ? 156.391 152.185 155.081 1.00 77.61  ? 100 LYS D O   1 
ATOM 3253 C CB  . LYS B 2 94  ? 154.878 149.192 155.355 1.00 77.61  ? 100 LYS D CB  1 
ATOM 3254 C CG  . LYS B 2 94  ? 156.199 148.687 154.808 1.00 77.61  ? 100 LYS D CG  1 
ATOM 3255 C CD  . LYS B 2 94  ? 156.204 147.174 154.705 1.00 77.61  ? 100 LYS D CD  1 
ATOM 3256 C CE  . LYS B 2 94  ? 157.521 146.667 154.146 1.00 77.61  ? 100 LYS D CE  1 
ATOM 3257 N NZ  . LYS B 2 94  ? 158.683 147.384 154.738 1.00 77.61  ? 100 LYS D NZ  1 
ATOM 3258 N N   . GLU B 2 95  ? 154.310 151.984 154.242 1.00 79.55  ? 101 GLU D N   1 
ATOM 3259 C CA  . GLU B 2 95  ? 154.547 153.008 153.230 1.00 79.55  ? 101 GLU D CA  1 
ATOM 3260 C C   . GLU B 2 95  ? 154.444 154.407 153.822 1.00 79.55  ? 101 GLU D C   1 
ATOM 3261 O O   . GLU B 2 95  ? 154.833 155.391 153.182 1.00 79.55  ? 101 GLU D O   1 
ATOM 3262 C CB  . GLU B 2 95  ? 153.571 152.858 152.057 1.00 79.55  ? 101 GLU D CB  1 
ATOM 3263 C CG  . GLU B 2 95  ? 153.415 151.456 151.447 1.00 79.55  ? 101 GLU D CG  1 
ATOM 3264 C CD  . GLU B 2 95  ? 152.788 150.433 152.378 1.00 79.55  ? 101 GLU D CD  1 
ATOM 3265 O OE1 . GLU B 2 95  ? 152.794 149.232 152.031 1.00 79.55  ? 101 GLU D OE1 1 
ATOM 3266 O OE2 . GLU B 2 95  ? 152.282 150.827 153.450 1.00 79.55  ? 101 GLU D OE2 1 
ATOM 3267 N N   . ASN B 2 96  ? 153.915 154.519 155.041 1.00 76.82  ? 102 ASN D N   1 
ATOM 3268 C CA  . ASN B 2 96  ? 153.667 155.835 155.619 1.00 76.82  ? 102 ASN D CA  1 
ATOM 3269 C C   . ASN B 2 96  ? 154.937 156.500 156.135 1.00 76.82  ? 102 ASN D C   1 
ATOM 3270 O O   . ASN B 2 96  ? 155.074 157.724 156.034 1.00 76.82  ? 102 ASN D O   1 
ATOM 3271 C CB  . ASN B 2 96  ? 152.644 155.723 156.749 1.00 76.82  ? 102 ASN D CB  1 
ATOM 3272 C CG  . ASN B 2 96  ? 151.321 156.364 156.398 1.00 76.82  ? 102 ASN D CG  1 
ATOM 3273 O OD1 . ASN B 2 96  ? 151.122 156.824 155.275 1.00 76.82  ? 102 ASN D OD1 1 
ATOM 3274 N ND2 . ASN B 2 96  ? 150.408 156.403 157.360 1.00 76.82  ? 102 ASN D ND2 1 
ATOM 3275 N N   . VAL B 2 97  ? 155.881 155.715 156.665 1.00 75.21  ? 103 VAL D N   1 
ATOM 3276 C CA  . VAL B 2 97  ? 156.928 156.261 157.533 1.00 75.21  ? 103 VAL D CA  1 
ATOM 3277 C C   . VAL B 2 97  ? 157.727 157.343 156.820 1.00 75.21  ? 103 VAL D C   1 
ATOM 3278 O O   . VAL B 2 97  ? 157.892 158.458 157.331 1.00 75.21  ? 103 VAL D O   1 
ATOM 3279 C CB  . VAL B 2 97  ? 157.853 155.139 158.032 1.00 75.21  ? 103 VAL D CB  1 
ATOM 3280 C CG1 . VAL B 2 97  ? 158.824 155.678 159.066 1.00 75.21  ? 103 VAL D CG1 1 
ATOM 3281 C CG2 . VAL B 2 97  ? 157.041 154.015 158.608 1.00 75.21  ? 103 VAL D CG2 1 
ATOM 3282 N N   . ASP B 2 98  ? 158.231 157.032 155.625 1.00 80.30  ? 104 ASP D N   1 
ATOM 3283 C CA  . ASP B 2 98  ? 159.120 157.958 154.933 1.00 80.30  ? 104 ASP D CA  1 
ATOM 3284 C C   . ASP B 2 98  ? 158.414 159.275 154.633 1.00 80.30  ? 104 ASP D C   1 
ATOM 3285 O O   . ASP B 2 98  ? 158.914 160.357 154.959 1.00 80.30  ? 104 ASP D O   1 
ATOM 3286 C CB  . ASP B 2 98  ? 159.641 157.319 153.644 1.00 80.30  ? 104 ASP D CB  1 
ATOM 3287 C CG  . ASP B 2 98  ? 159.852 155.823 153.777 1.00 80.30  ? 104 ASP D CG  1 
ATOM 3288 O OD1 . ASP B 2 98  ? 160.545 155.397 154.724 1.00 80.30  ? 104 ASP D OD1 1 
ATOM 3289 O OD2 . ASP B 2 98  ? 159.324 155.073 152.931 1.00 80.30  ? 104 ASP D OD2 1 
ATOM 3290 N N   . GLU B 2 99  ? 157.225 159.195 154.035 1.00 81.70  ? 105 GLU D N   1 
ATOM 3291 C CA  . GLU B 2 99  ? 156.536 160.409 153.614 1.00 81.70  ? 105 GLU D CA  1 
ATOM 3292 C C   . GLU B 2 99  ? 155.973 161.172 154.807 1.00 81.70  ? 105 GLU D C   1 
ATOM 3293 O O   . GLU B 2 99  ? 156.002 162.409 154.828 1.00 81.70  ? 105 GLU D O   1 
ATOM 3294 C CB  . GLU B 2 99  ? 155.431 160.060 152.618 1.00 81.70  ? 105 GLU D CB  1 
ATOM 3295 C CG  . GLU B 2 99  ? 155.931 159.790 151.199 1.00 81.70  ? 105 GLU D CG  1 
ATOM 3296 C CD  . GLU B 2 99  ? 156.339 161.042 150.439 1.00 81.70  ? 105 GLU D CD  1 
ATOM 3297 O OE1 . GLU B 2 99  ? 156.042 161.113 149.229 1.00 81.70  ? 105 GLU D OE1 1 
ATOM 3298 O OE2 . GLU B 2 99  ? 156.957 161.950 151.032 1.00 81.70  ? 105 GLU D OE2 1 
ATOM 3299 N N   . VAL B 2 100 ? 155.461 160.458 155.813 1.00 75.46  ? 106 VAL D N   1 
ATOM 3300 C CA  . VAL B 2 100 ? 154.917 161.143 156.982 1.00 75.46  ? 106 VAL D CA  1 
ATOM 3301 C C   . VAL B 2 100 ? 156.026 161.828 157.769 1.00 75.46  ? 106 VAL D C   1 
ATOM 3302 O O   . VAL B 2 100 ? 155.793 162.860 158.408 1.00 75.46  ? 106 VAL D O   1 
ATOM 3303 C CB  . VAL B 2 100 ? 154.109 160.171 157.862 1.00 75.46  ? 106 VAL D CB  1 
ATOM 3304 C CG1 . VAL B 2 100 ? 155.024 159.342 158.742 1.00 75.46  ? 106 VAL D CG1 1 
ATOM 3305 C CG2 . VAL B 2 100 ? 153.111 160.935 158.707 1.00 75.46  ? 106 VAL D CG2 1 
ATOM 3306 N N   . CYS B 2 101 ? 157.244 161.281 157.742 1.00 83.40  ? 107 CYS D N   1 
ATOM 3307 C CA  . CYS B 2 101 ? 158.362 161.970 158.377 1.00 83.40  ? 107 CYS D CA  1 
ATOM 3308 C C   . CYS B 2 101 ? 158.838 163.137 157.523 1.00 83.40  ? 107 CYS D C   1 
ATOM 3309 O O   . CYS B 2 101 ? 159.232 164.181 158.053 1.00 83.40  ? 107 CYS D O   1 
ATOM 3310 C CB  . CYS B 2 101 ? 159.505 160.989 158.640 1.00 83.40  ? 107 CYS D CB  1 
ATOM 3311 S SG  . CYS B 2 101 ? 161.143 161.748 158.729 1.00 83.40  ? 107 CYS D SG  1 
ATOM 3312 N N   . LYS B 2 102 ? 158.794 162.981 156.198 1.00 83.59  ? 108 LYS D N   1 
ATOM 3313 C CA  . LYS B 2 102 ? 159.234 164.044 155.300 1.00 83.59  ? 108 LYS D CA  1 
ATOM 3314 C C   . LYS B 2 102 ? 158.281 165.233 155.336 1.00 83.59  ? 108 LYS D C   1 
ATOM 3315 O O   . LYS B 2 102 ? 158.663 166.363 155.010 1.00 83.59  ? 108 LYS D O   1 
ATOM 3316 C CB  . LYS B 2 102 ? 159.358 163.491 153.880 1.00 83.59  ? 108 LYS D CB  1 
ATOM 3317 C CG  . LYS B 2 102 ? 160.372 164.204 153.010 1.00 83.59  ? 108 LYS D CG  1 
ATOM 3318 C CD  . LYS B 2 102 ? 160.553 163.473 151.692 1.00 83.59  ? 108 LYS D CD  1 
ATOM 3319 C CE  . LYS B 2 102 ? 159.569 163.970 150.649 1.00 83.59  ? 108 LYS D CE  1 
ATOM 3320 N NZ  . LYS B 2 102 ? 159.671 165.438 150.462 1.00 83.59  ? 108 LYS D NZ  1 
ATOM 3321 N N   . CYS B 2 103 ? 157.023 164.990 155.704 1.00 85.00  ? 109 CYS D N   1 
ATOM 3322 C CA  . CYS B 2 103 ? 156.061 166.085 155.793 1.00 85.00  ? 109 CYS D CA  1 
ATOM 3323 C C   . CYS B 2 103 ? 156.393 167.040 156.934 1.00 85.00  ? 109 CYS D C   1 
ATOM 3324 O O   . CYS B 2 103 ? 156.140 168.247 156.837 1.00 85.00  ? 109 CYS D O   1 
ATOM 3325 C CB  . CYS B 2 103 ? 154.646 165.532 155.963 1.00 85.00  ? 109 CYS D CB  1 
ATOM 3326 S SG  . CYS B 2 103 ? 153.961 164.747 154.490 1.00 85.00  ? 109 CYS D SG  1 
ATOM 3327 N N   . VAL B 2 104 ? 156.955 166.519 158.024 1.00 83.01  ? 110 VAL D N   1 
ATOM 3328 C CA  . VAL B 2 104 ? 157.090 167.269 159.270 1.00 83.01  ? 110 VAL D CA  1 
ATOM 3329 C C   . VAL B 2 104 ? 158.011 168.477 159.125 1.00 83.01  ? 110 VAL D C   1 
ATOM 3330 O O   . VAL B 2 104 ? 157.661 169.581 159.555 1.00 83.01  ? 110 VAL D O   1 
ATOM 3331 C CB  . VAL B 2 104 ? 157.582 166.354 160.405 1.00 83.01  ? 110 VAL D CB  1 
ATOM 3332 C CG1 . VAL B 2 104 ? 157.576 167.104 161.724 1.00 83.01  ? 110 VAL D CG1 1 
ATOM 3333 C CG2 . VAL B 2 104 ? 156.712 165.116 160.497 1.00 83.01  ? 110 VAL D CG2 1 
ATOM 3334 N N   . GLU B 2 105 ? 159.188 168.288 158.523 1.00 85.68  ? 111 GLU D N   1 
ATOM 3335 C CA  . GLU B 2 105 ? 160.174 169.366 158.517 1.00 85.68  ? 111 GLU D CA  1 
ATOM 3336 C C   . GLU B 2 105 ? 159.739 170.532 157.633 1.00 85.68  ? 111 GLU D C   1 
ATOM 3337 O O   . GLU B 2 105 ? 160.161 171.672 157.852 1.00 85.68  ? 111 GLU D O   1 
ATOM 3338 C CB  . GLU B 2 105 ? 161.554 168.855 158.083 1.00 85.68  ? 111 GLU D CB  1 
ATOM 3339 C CG  . GLU B 2 105 ? 161.955 167.461 158.565 1.00 85.68  ? 111 GLU D CG  1 
ATOM 3340 C CD  . GLU B 2 105 ? 161.307 166.341 157.781 1.00 85.68  ? 111 GLU D CD  1 
ATOM 3341 O OE1 . GLU B 2 105 ? 161.843 165.212 157.802 1.00 85.68  ? 111 GLU D OE1 1 
ATOM 3342 O OE2 . GLU B 2 105 ? 160.269 166.588 157.140 1.00 85.68  ? 111 GLU D OE2 1 
ATOM 3343 N N   . PHE B 2 106 ? 158.896 170.273 156.633 1.00 84.18  ? 112 PHE D N   1 
ATOM 3344 C CA  . PHE B 2 106 ? 158.395 171.359 155.797 1.00 84.18  ? 112 PHE D CA  1 
ATOM 3345 C C   . PHE B 2 106 ? 157.271 172.114 156.493 1.00 84.18  ? 112 PHE D C   1 
ATOM 3346 O O   . PHE B 2 106 ? 156.816 173.153 156.005 1.00 84.18  ? 112 PHE D O   1 
ATOM 3347 C CB  . PHE B 2 106 ? 157.896 170.836 154.450 1.00 84.18  ? 112 PHE D CB  1 
ATOM 3348 C CG  . PHE B 2 106 ? 157.826 171.891 153.385 1.00 84.18  ? 112 PHE D CG  1 
ATOM 3349 C CD1 . PHE B 2 106 ? 158.577 173.050 153.490 1.00 84.18  ? 112 PHE D CD1 1 
ATOM 3350 C CD2 . PHE B 2 106 ? 156.973 171.749 152.306 1.00 84.18  ? 112 PHE D CD2 1 
ATOM 3351 C CE1 . PHE B 2 106 ? 158.505 174.031 152.520 1.00 84.18  ? 112 PHE D CE1 1 
ATOM 3352 C CE2 . PHE B 2 106 ? 156.892 172.728 151.335 1.00 84.18  ? 112 PHE D CE2 1 
ATOM 3353 C CZ  . PHE B 2 106 ? 157.661 173.870 151.441 1.00 84.18  ? 112 PHE D CZ  1 
ATOM 3354 N N   . LEU B 2 107 ? 156.818 171.602 157.632 1.00 82.92  ? 113 LEU D N   1 
ATOM 3355 C CA  . LEU B 2 107 ? 155.702 172.218 158.332 1.00 82.92  ? 113 LEU D CA  1 
ATOM 3356 C C   . LEU B 2 107 ? 156.106 172.574 159.754 1.00 82.92  ? 113 LEU D C   1 
ATOM 3357 O O   . LEU B 2 107 ? 155.585 173.534 160.332 1.00 82.92  ? 113 LEU D O   1 
ATOM 3358 C CB  . LEU B 2 107 ? 154.499 171.277 158.333 1.00 82.92  ? 113 LEU D CB  1 
ATOM 3359 C CG  . LEU B 2 107 ? 153.861 171.040 156.967 1.00 82.92  ? 113 LEU D CG  1 
ATOM 3360 C CD1 . LEU B 2 107 ? 153.010 169.790 157.004 1.00 82.92  ? 113 LEU D CD1 1 
ATOM 3361 C CD2 . LEU B 2 107 ? 153.039 172.242 156.541 1.00 82.92  ? 113 LEU D CD2 1 
ATOM 3362 N N   . SER B 2 108 ? 157.045 171.809 160.314 1.00 84.67  ? 114 SER D N   1 
ATOM 3363 C CA  . SER B 2 108 ? 157.519 171.980 161.686 1.00 84.67  ? 114 SER D CA  1 
ATOM 3364 C C   . SER B 2 108 ? 156.340 172.020 162.663 1.00 84.67  ? 114 SER D C   1 
ATOM 3365 O O   . SER B 2 108 ? 156.225 172.892 163.526 1.00 84.67  ? 114 SER D O   1 
ATOM 3366 C CB  . SER B 2 108 ? 158.396 173.232 161.810 1.00 84.67  ? 114 SER D CB  1 
ATOM 3367 O OG  . SER B 2 108 ? 157.668 174.405 161.498 1.00 84.67  ? 114 SER D OG  1 
ATOM 3368 N N   . VAL B 2 109 ? 155.459 171.041 162.488 1.00 76.62  ? 115 VAL D N   1 
ATOM 3369 C CA  . VAL B 2 109 ? 154.293 170.874 163.347 1.00 76.62  ? 115 VAL D CA  1 
ATOM 3370 C C   . VAL B 2 109 ? 154.792 170.560 164.753 1.00 76.62  ? 115 VAL D C   1 
ATOM 3371 O O   . VAL B 2 109 ? 155.703 169.750 164.936 1.00 76.62  ? 115 VAL D O   1 
ATOM 3372 C CB  . VAL B 2 109 ? 153.348 169.791 162.808 1.00 76.62  ? 115 VAL D CB  1 
ATOM 3373 C CG1 . VAL B 2 109 ? 154.094 168.502 162.555 1.00 76.62  ? 115 VAL D CG1 1 
ATOM 3374 C CG2 . VAL B 2 109 ? 152.204 169.549 163.777 1.00 76.62  ? 115 VAL D CG2 1 
ATOM 3375 N N   . HIS B 2 110 ? 154.222 171.238 165.746 1.00 74.00  ? 116 HIS D N   1 
ATOM 3376 C CA  . HIS B 2 110 ? 154.754 171.178 167.100 1.00 74.00  ? 116 HIS D CA  1 
ATOM 3377 C C   . HIS B 2 110 ? 154.275 169.928 167.824 1.00 74.00  ? 116 HIS D C   1 
ATOM 3378 O O   . HIS B 2 110 ? 153.355 169.240 167.374 1.00 74.00  ? 116 HIS D O   1 
ATOM 3379 C CB  . HIS B 2 110 ? 154.340 172.426 167.879 1.00 74.00  ? 116 HIS D CB  1 
ATOM 3380 C CG  . HIS B 2 110 ? 154.947 173.690 167.358 1.00 74.00  ? 116 HIS D CG  1 
ATOM 3381 N ND1 . HIS B 2 110 ? 156.206 173.736 166.802 1.00 74.00  ? 116 HIS D ND1 1 
ATOM 3382 C CD2 . HIS B 2 110 ? 154.465 174.954 167.303 1.00 74.00  ? 116 HIS D CD2 1 
ATOM 3383 C CE1 . HIS B 2 110 ? 156.476 174.974 166.429 1.00 74.00  ? 116 HIS D CE1 1 
ATOM 3384 N NE2 . HIS B 2 110 ? 155.435 175.733 166.722 1.00 74.00  ? 116 HIS D NE2 1 
ATOM 3385 N N   . ASN B 2 111 ? 154.913 169.644 168.960 1.00 69.68  ? 117 ASN D N   1 
ATOM 3386 C CA  . ASN B 2 111 ? 154.579 168.546 169.864 1.00 69.68  ? 117 ASN D CA  1 
ATOM 3387 C C   . ASN B 2 111 ? 154.676 167.175 169.212 1.00 69.68  ? 117 ASN D C   1 
ATOM 3388 O O   . ASN B 2 111 ? 154.087 166.212 169.712 1.00 69.68  ? 117 ASN D O   1 
ATOM 3389 C CB  . ASN B 2 111 ? 153.189 168.719 170.484 1.00 69.68  ? 117 ASN D CB  1 
ATOM 3390 C CG  . ASN B 2 111 ? 152.809 170.172 170.664 1.00 69.68  ? 117 ASN D CG  1 
ATOM 3391 O OD1 . ASN B 2 111 ? 152.267 170.805 169.759 1.00 69.68  ? 117 ASN D OD1 1 
ATOM 3392 N ND2 . ASN B 2 111 ? 153.118 170.718 171.832 1.00 69.68  ? 117 ASN D ND2 1 
ATOM 3393 N N   . ILE B 2 112 ? 155.408 167.052 168.111 1.00 76.87  ? 118 ILE D N   1 
ATOM 3394 C CA  . ILE B 2 112 ? 155.719 165.763 167.508 1.00 76.87  ? 118 ILE D CA  1 
ATOM 3395 C C   . ILE B 2 112 ? 157.231 165.687 167.365 1.00 76.87  ? 118 ILE D C   1 
ATOM 3396 O O   . ILE B 2 112 ? 157.874 166.667 166.969 1.00 76.87  ? 118 ILE D O   1 
ATOM 3397 C CB  . ILE B 2 112 ? 155.021 165.573 166.153 1.00 76.87  ? 118 ILE D CB  1 
ATOM 3398 C CG1 . ILE B 2 112 ? 155.399 164.225 165.542 1.00 76.87  ? 118 ILE D CG1 1 
ATOM 3399 C CG2 . ILE B 2 112 ? 155.380 166.686 165.210 1.00 76.87  ? 118 ILE D CG2 1 
ATOM 3400 C CD1 . ILE B 2 112 ? 154.488 163.789 164.423 1.00 76.87  ? 118 ILE D CD1 1 
ATOM 3401 N N   . GLU B 2 113 ? 157.802 164.542 167.717 1.00 79.51  ? 119 GLU D N   1 
ATOM 3402 C CA  . GLU B 2 113 ? 159.248 164.377 167.677 1.00 79.51  ? 119 GLU D CA  1 
ATOM 3403 C C   . GLU B 2 113 ? 159.632 163.391 166.581 1.00 79.51  ? 119 GLU D C   1 
ATOM 3404 O O   . GLU B 2 113 ? 159.099 162.279 166.520 1.00 79.51  ? 119 GLU D O   1 
ATOM 3405 C CB  . GLU B 2 113 ? 159.753 163.938 169.047 1.00 79.51  ? 119 GLU D CB  1 
ATOM 3406 C CG  . GLU B 2 113 ? 158.788 163.044 169.789 1.00 79.51  ? 119 GLU D CG  1 
ATOM 3407 C CD  . GLU B 2 113 ? 159.152 162.903 171.249 1.00 79.51  ? 119 GLU D CD  1 
ATOM 3408 O OE1 . GLU B 2 113 ? 160.354 162.782 171.562 1.00 79.51  ? 119 GLU D OE1 1 
ATOM 3409 O OE2 . GLU B 2 113 ? 158.233 162.964 172.090 1.00 79.51  ? 119 GLU D OE2 1 
ATOM 3410 N N   . GLU B 2 114 ? 160.559 163.804 165.717 1.00 83.80  ? 120 GLU D N   1 
ATOM 3411 C CA  . GLU B 2 114 ? 160.872 163.056 164.507 1.00 83.80  ? 120 GLU D CA  1 
ATOM 3412 C C   . GLU B 2 114 ? 162.104 162.183 164.697 1.00 83.80  ? 120 GLU D C   1 
ATOM 3413 O O   . GLU B 2 114 ? 162.788 161.845 163.726 1.00 83.80  ? 120 GLU D O   1 
ATOM 3414 C CB  . GLU B 2 114 ? 161.089 164.007 163.327 1.00 83.80  ? 120 GLU D CB  1 
ATOM 3415 C CG  . GLU B 2 114 ? 161.758 165.335 163.679 1.00 83.80  ? 120 GLU D CG  1 
ATOM 3416 C CD  . GLU B 2 114 ? 160.793 166.384 164.208 1.00 83.80  ? 120 GLU D CD  1 
ATOM 3417 O OE1 . GLU B 2 114 ? 160.997 167.579 163.908 1.00 83.80  ? 120 GLU D OE1 1 
ATOM 3418 O OE2 . GLU B 2 114 ? 159.838 166.021 164.924 1.00 83.80  ? 120 GLU D OE2 1 
ATOM 3419 N N   . SER B 2 115 ? 162.397 161.810 165.941 1.00 70.62  ? 121 SER D N   1 
ATOM 3420 C CA  . SER B 2 115 ? 163.522 160.929 166.217 1.00 70.62  ? 121 SER D CA  1 
ATOM 3421 C C   . SER B 2 115 ? 163.011 159.596 166.740 1.00 70.62  ? 121 SER D C   1 
ATOM 3422 O O   . SER B 2 115 ? 163.712 158.583 166.675 1.00 70.62  ? 121 SER D O   1 
ATOM 3423 C CB  . SER B 2 115 ? 164.478 161.571 167.222 1.00 70.62  ? 121 SER D CB  1 
ATOM 3424 O OG  . SER B 2 115 ? 164.049 161.334 168.552 1.00 70.62  ? 121 SER D OG  1 
ATOM 3425 N N   . CYS B 2 116 ? 161.781 159.591 167.256 1.00 72.39  ? 122 CYS D N   1 
ATOM 3426 C CA  . CYS B 2 116 ? 161.187 158.349 167.729 1.00 72.39  ? 122 CYS D CA  1 
ATOM 3427 C C   . CYS B 2 116 ? 160.795 157.442 166.569 1.00 72.39  ? 122 CYS D C   1 
ATOM 3428 O O   . CYS B 2 116 ? 160.731 156.218 166.735 1.00 72.39  ? 122 CYS D O   1 
ATOM 3429 C CB  . CYS B 2 116 ? 159.977 158.656 168.610 1.00 72.39  ? 122 CYS D CB  1 
ATOM 3430 S SG  . CYS B 2 116 ? 158.867 157.264 168.908 1.00 72.39  ? 122 CYS D SG  1 
ATOM 3431 N N   . PHE B 2 117 ? 160.550 158.016 165.388 1.00 75.34  ? 123 PHE D N   1 
ATOM 3432 C CA  . PHE B 2 117 ? 160.152 157.213 164.235 1.00 75.34  ? 123 PHE D CA  1 
ATOM 3433 C C   . PHE B 2 117 ? 161.238 156.228 163.825 1.00 75.34  ? 123 PHE D C   1 
ATOM 3434 O O   . PHE B 2 117 ? 160.929 155.154 163.296 1.00 75.34  ? 123 PHE D O   1 
ATOM 3435 C CB  . PHE B 2 117 ? 159.794 158.119 163.059 1.00 75.34  ? 123 PHE D CB  1 
ATOM 3436 C CG  . PHE B 2 117 ? 158.577 158.962 163.294 1.00 75.34  ? 123 PHE D CG  1 
ATOM 3437 C CD1 . PHE B 2 117 ? 157.586 158.540 164.162 1.00 75.34  ? 123 PHE D CD1 1 
ATOM 3438 C CD2 . PHE B 2 117 ? 158.427 160.178 162.656 1.00 75.34  ? 123 PHE D CD2 1 
ATOM 3439 C CE1 . PHE B 2 117 ? 156.467 159.313 164.383 1.00 75.34  ? 123 PHE D CE1 1 
ATOM 3440 C CE2 . PHE B 2 117 ? 157.310 160.956 162.874 1.00 75.34  ? 123 PHE D CE2 1 
ATOM 3441 C CZ  . PHE B 2 117 ? 156.329 160.522 163.740 1.00 75.34  ? 123 PHE D CZ  1 
ATOM 3442 N N   . GLN B 2 118 ? 162.506 156.562 164.063 1.00 67.63  ? 124 GLN D N   1 
ATOM 3443 C CA  . GLN B 2 118 ? 163.596 155.661 163.711 1.00 67.63  ? 124 GLN D CA  1 
ATOM 3444 C C   . GLN B 2 118 ? 163.778 154.611 164.796 1.00 67.63  ? 124 GLN D C   1 
ATOM 3445 O O   . GLN B 2 118 ? 164.895 154.377 165.266 1.00 67.63  ? 124 GLN D O   1 
ATOM 3446 C CB  . GLN B 2 118 ? 164.891 156.448 163.508 1.00 67.63  ? 124 GLN D CB  1 
ATOM 3447 C CG  . GLN B 2 118 ? 165.579 156.193 162.184 1.00 67.63  ? 124 GLN D CG  1 
ATOM 3448 C CD  . GLN B 2 118 ? 166.463 157.349 161.766 1.00 67.63  ? 124 GLN D CD  1 
ATOM 3449 O OE1 . GLN B 2 118 ? 166.677 158.288 162.532 1.00 67.63  ? 124 GLN D OE1 1 
ATOM 3450 N NE2 . GLN B 2 118 ? 166.980 157.289 160.545 1.00 67.63  ? 124 GLN D NE2 1 
ATOM 3451 N N   . PHE B 2 119 ? 162.682 153.971 165.193 1.00 64.46  ? 125 PHE D N   1 
ATOM 3452 C CA  . PHE B 2 119 ? 162.709 152.933 166.212 1.00 64.46  ? 125 PHE D CA  1 
ATOM 3453 C C   . PHE B 2 119 ? 161.832 151.772 165.767 1.00 64.46  ? 125 PHE D C   1 
ATOM 3454 O O   . PHE B 2 119 ? 162.014 150.632 166.206 1.00 64.46  ? 125 PHE D O   1 
ATOM 3455 C CB  . PHE B 2 119 ? 162.242 153.501 167.555 1.00 64.46  ? 125 PHE D CB  1 
ATOM 3456 C CG  . PHE B 2 119 ? 161.756 152.462 168.521 1.00 64.46  ? 125 PHE D CG  1 
ATOM 3457 C CD1 . PHE B 2 119 ? 162.650 151.697 169.244 1.00 64.46  ? 125 PHE D CD1 1 
ATOM 3458 C CD2 . PHE B 2 119 ? 160.403 152.248 168.703 1.00 64.46  ? 125 PHE D CD2 1 
ATOM 3459 C CE1 . PHE B 2 119 ? 162.202 150.743 170.130 1.00 64.46  ? 125 PHE D CE1 1 
ATOM 3460 C CE2 . PHE B 2 119 ? 159.953 151.292 169.586 1.00 64.46  ? 125 PHE D CE2 1 
ATOM 3461 C CZ  . PHE B 2 119 ? 160.853 150.539 170.299 1.00 64.46  ? 125 PHE D CZ  1 
ATOM 3462 N N   . LEU B 2 120 ? 160.888 152.062 164.876 1.00 70.61  ? 126 LEU D N   1 
ATOM 3463 C CA  . LEU B 2 120 ? 159.902 151.082 164.452 1.00 70.61  ? 126 LEU D CA  1 
ATOM 3464 C C   . LEU B 2 120 ? 160.548 149.986 163.613 1.00 70.61  ? 126 LEU D C   1 
ATOM 3465 O O   . LEU B 2 120 ? 161.469 150.231 162.831 1.00 70.61  ? 126 LEU D O   1 
ATOM 3466 C CB  . LEU B 2 120 ? 158.801 151.767 163.648 1.00 70.61  ? 126 LEU D CB  1 
ATOM 3467 C CG  . LEU B 2 120 ? 158.167 152.982 164.325 1.00 70.61  ? 126 LEU D CG  1 
ATOM 3468 C CD1 . LEU B 2 120 ? 157.820 154.036 163.295 1.00 70.61  ? 126 LEU D CD1 1 
ATOM 3469 C CD2 . LEU B 2 120 ? 156.940 152.579 165.114 1.00 70.61  ? 126 LEU D CD2 1 
ATOM 3470 N N   . LYS B 2 121 ? 160.049 148.763 163.779 1.00 80.85  ? 127 LYS D N   1 
ATOM 3471 C CA  . LYS B 2 121 ? 160.541 147.646 162.984 1.00 80.85  ? 127 LYS D CA  1 
ATOM 3472 C C   . LYS B 2 121 ? 160.025 147.750 161.556 1.00 80.85  ? 127 LYS D C   1 
ATOM 3473 O O   . LYS B 2 121 ? 160.810 147.933 160.621 1.00 80.85  ? 127 LYS D O   1 
ATOM 3474 C CB  . LYS B 2 121 ? 160.119 146.315 163.608 1.00 80.85  ? 127 LYS D CB  1 
ATOM 3475 C CG  . LYS B 2 121 ? 160.484 145.091 162.782 1.00 80.85  ? 127 LYS D CG  1 
ATOM 3476 C CD  . LYS B 2 121 ? 161.951 145.099 162.383 1.00 80.85  ? 127 LYS D CD  1 
ATOM 3477 C CE  . LYS B 2 121 ? 162.553 143.706 162.457 1.00 80.85  ? 127 LYS D CE  1 
ATOM 3478 N NZ  . LYS B 2 121 ? 161.516 142.661 162.676 1.00 80.85  ? 127 LYS D NZ  1 
ATOM 3479 N N   . PHE B 2 122 ? 158.707 147.659 161.392 1.00 81.49  ? 128 PHE D N   1 
ATOM 3480 C CA  . PHE B 2 122 ? 158.046 147.788 160.094 1.00 81.49  ? 128 PHE D CA  1 
ATOM 3481 C C   . PHE B 2 122 ? 158.705 146.954 158.998 1.00 81.49  ? 128 PHE D C   1 
ATOM 3482 O O   . PHE B 2 122 ? 159.422 147.483 158.148 1.00 81.49  ? 128 PHE D O   1 
ATOM 3483 C CB  . PHE B 2 122 ? 158.005 149.257 159.677 1.00 81.49  ? 128 PHE D CB  1 
ATOM 3484 C CG  . PHE B 2 122 ? 156.820 149.999 160.216 1.00 81.49  ? 128 PHE D CG  1 
ATOM 3485 C CD1 . PHE B 2 122 ? 155.576 149.399 160.262 1.00 81.49  ? 128 PHE D CD1 1 
ATOM 3486 C CD2 . PHE B 2 122 ? 156.949 151.295 160.675 1.00 81.49  ? 128 PHE D CD2 1 
ATOM 3487 C CE1 . PHE B 2 122 ? 154.482 150.080 160.757 1.00 81.49  ? 128 PHE D CE1 1 
ATOM 3488 C CE2 . PHE B 2 122 ? 155.860 151.980 161.173 1.00 81.49  ? 128 PHE D CE2 1 
ATOM 3489 C CZ  . PHE B 2 122 ? 154.625 151.372 161.213 1.00 81.49  ? 128 PHE D CZ  1 
ATOM 3490 N N   . SER C 2 1   ? 151.361 144.885 161.020 1.00 77.18  ? 7   SER E N   1 
ATOM 3491 C CA  . SER C 2 1   ? 152.499 145.796 161.020 1.00 77.18  ? 7   SER E CA  1 
ATOM 3492 C C   . SER C 2 1   ? 152.043 147.243 160.901 1.00 77.18  ? 7   SER E C   1 
ATOM 3493 O O   . SER C 2 1   ? 152.398 147.938 159.950 1.00 77.18  ? 7   SER E O   1 
ATOM 3494 C CB  . SER C 2 1   ? 153.460 145.455 159.881 1.00 77.18  ? 7   SER E CB  1 
ATOM 3495 O OG  . SER C 2 1   ? 154.711 146.094 160.065 1.00 77.18  ? 7   SER E OG  1 
ATOM 3496 N N   . VAL C 2 2   ? 151.245 147.690 161.866 1.00 71.12  ? 8   VAL E N   1 
ATOM 3497 C CA  . VAL C 2 2   ? 150.763 149.064 161.927 1.00 71.12  ? 8   VAL E CA  1 
ATOM 3498 C C   . VAL C 2 2   ? 151.015 149.586 163.333 1.00 71.12  ? 8   VAL E C   1 
ATOM 3499 O O   . VAL C 2 2   ? 150.664 148.924 164.316 1.00 71.12  ? 8   VAL E O   1 
ATOM 3500 C CB  . VAL C 2 2   ? 149.271 149.159 161.560 1.00 71.12  ? 8   VAL E CB  1 
ATOM 3501 C CG1 . VAL C 2 2   ? 148.703 150.501 161.976 1.00 71.12  ? 8   VAL E CG1 1 
ATOM 3502 C CG2 . VAL C 2 2   ? 149.078 148.936 160.069 1.00 71.12  ? 8   VAL E CG2 1 
ATOM 3503 N N   . PHE C 2 3   ? 151.621 150.766 163.427 1.00 67.25  ? 9   PHE E N   1 
ATOM 3504 C CA  . PHE C 2 3   ? 151.977 151.356 164.707 1.00 67.25  ? 9   PHE E CA  1 
ATOM 3505 C C   . PHE C 2 3   ? 151.222 152.661 164.908 1.00 67.25  ? 9   PHE E C   1 
ATOM 3506 O O   . PHE C 2 3   ? 150.843 153.342 163.952 1.00 67.25  ? 9   PHE E O   1 
ATOM 3507 C CB  . PHE C 2 3   ? 153.483 151.609 164.815 1.00 67.25  ? 9   PHE E CB  1 
ATOM 3508 C CG  . PHE C 2 3   ? 154.255 150.440 165.344 1.00 67.25  ? 9   PHE E CG  1 
ATOM 3509 C CD1 . PHE C 2 3   ? 154.286 150.176 166.700 1.00 67.25  ? 9   PHE E CD1 1 
ATOM 3510 C CD2 . PHE C 2 3   ? 154.956 149.612 164.490 1.00 67.25  ? 9   PHE E CD2 1 
ATOM 3511 C CE1 . PHE C 2 3   ? 154.995 149.105 167.192 1.00 67.25  ? 9   PHE E CE1 1 
ATOM 3512 C CE2 . PHE C 2 3   ? 155.669 148.539 164.979 1.00 67.25  ? 9   PHE E CE2 1 
ATOM 3513 C CZ  . PHE C 2 3   ? 155.688 148.285 166.331 1.00 67.25  ? 9   PHE E CZ  1 
ATOM 3514 N N   . ALA C 2 4   ? 151.013 153.001 166.174 1.00 61.57  ? 10  ALA E N   1 
ATOM 3515 C CA  . ALA C 2 4   ? 150.300 154.204 166.566 1.00 61.57  ? 10  ALA E CA  1 
ATOM 3516 C C   . ALA C 2 4   ? 151.248 155.160 167.277 1.00 61.57  ? 10  ALA E C   1 
ATOM 3517 O O   . ALA C 2 4   ? 152.333 154.784 167.725 1.00 61.57  ? 10  ALA E O   1 
ATOM 3518 C CB  . ALA C 2 4   ? 149.109 153.868 167.470 1.00 61.57  ? 10  ALA E CB  1 
ATOM 3519 N N   . TYR C 2 5   ? 150.821 156.416 167.369 1.00 76.28  ? 11  TYR E N   1 
ATOM 3520 C CA  . TYR C 2 5   ? 151.579 157.449 168.075 1.00 76.28  ? 11  TYR E CA  1 
ATOM 3521 C C   . TYR C 2 5   ? 150.556 158.302 168.824 1.00 76.28  ? 11  TYR E C   1 
ATOM 3522 O O   . TYR C 2 5   ? 149.980 159.236 168.264 1.00 76.28  ? 11  TYR E O   1 
ATOM 3523 C CB  . TYR C 2 5   ? 152.415 158.284 167.117 1.00 76.28  ? 11  TYR E CB  1 
ATOM 3524 C CG  . TYR C 2 5   ? 153.252 159.351 167.782 1.00 76.28  ? 11  TYR E CG  1 
ATOM 3525 C CD1 . TYR C 2 5   ? 152.723 160.598 168.075 1.00 76.28  ? 11  TYR E CD1 1 
ATOM 3526 C CD2 . TYR C 2 5   ? 154.573 159.114 168.110 1.00 76.28  ? 11  TYR E CD2 1 
ATOM 3527 C CE1 . TYR C 2 5   ? 153.484 161.571 168.681 1.00 76.28  ? 11  TYR E CE1 1 
ATOM 3528 C CE2 . TYR C 2 5   ? 155.343 160.082 168.713 1.00 76.28  ? 11  TYR E CE2 1 
ATOM 3529 C CZ  . TYR C 2 5   ? 154.793 161.308 168.996 1.00 76.28  ? 11  TYR E CZ  1 
ATOM 3530 O OH  . TYR C 2 5   ? 155.560 162.276 169.598 1.00 76.28  ? 11  TYR E OH  1 
ATOM 3531 N N   . GLU C 2 6   ? 150.330 157.960 170.086 1.00 57.68  ? 12  GLU E N   1 
ATOM 3532 C CA  . GLU C 2 6   ? 149.357 158.662 170.910 1.00 57.68  ? 12  GLU E CA  1 
ATOM 3533 C C   . GLU C 2 6   ? 150.088 159.622 171.837 1.00 57.68  ? 12  GLU E C   1 
ATOM 3534 O O   . GLU C 2 6   ? 150.864 159.192 172.697 1.00 57.68  ? 12  GLU E O   1 
ATOM 3535 C CB  . GLU C 2 6   ? 148.514 157.670 171.708 1.00 57.68  ? 12  GLU E CB  1 
ATOM 3536 C CG  . GLU C 2 6   ? 147.608 158.312 172.737 1.00 57.68  ? 12  GLU E CG  1 
ATOM 3537 C CD  . GLU C 2 6   ? 146.502 157.382 173.192 1.00 57.68  ? 12  GLU E CD  1 
ATOM 3538 O OE1 . GLU C 2 6   ? 146.543 156.188 172.826 1.00 57.68  ? 12  GLU E OE1 1 
ATOM 3539 O OE2 . GLU C 2 6   ? 145.593 157.843 173.913 1.00 57.68  ? 12  GLU E OE2 1 
ATOM 3540 N N   . SER C 2 7   ? 149.841 160.914 171.664 1.00 47.52  ? 13  SER E N   1 
ATOM 3541 C CA  . SER C 2 7   ? 150.491 161.942 172.454 1.00 47.52  ? 13  SER E CA  1 
ATOM 3542 C C   . SER C 2 7   ? 149.632 162.280 173.669 1.00 47.52  ? 13  SER E C   1 
ATOM 3543 O O   . SER C 2 7   ? 148.440 161.966 173.725 1.00 47.52  ? 13  SER E O   1 
ATOM 3544 C CB  . SER C 2 7   ? 150.762 163.174 171.588 1.00 47.52  ? 13  SER E CB  1 
ATOM 3545 O OG  . SER C 2 7   ? 151.758 163.996 172.169 1.00 47.52  ? 13  SER E OG  1 
ATOM 3546 N N   . SER C 2 8   ? 150.246 162.927 174.663 1.00 51.93  ? 14  SER E N   1 
ATOM 3547 C CA  . SER C 2 8   ? 149.474 163.335 175.842 1.00 51.93  ? 14  SER E CA  1 
ATOM 3548 C C   . SER C 2 8   ? 149.676 164.802 176.191 1.00 51.93  ? 14  SER E C   1 
ATOM 3549 O O   . SER C 2 8   ? 149.209 165.229 177.253 1.00 51.93  ? 14  SER E O   1 
ATOM 3550 C CB  . SER C 2 8   ? 149.838 162.456 177.041 1.00 51.93  ? 14  SER E CB  1 
ATOM 3551 O OG  . SER C 2 8   ? 148.970 161.341 177.136 1.00 51.93  ? 14  SER E OG  1 
ATOM 3552 N N   . VAL C 2 9   ? 150.348 165.590 175.351 1.00 51.28  ? 15  VAL E N   1 
ATOM 3553 C CA  . VAL C 2 9   ? 150.570 167.004 175.614 1.00 51.28  ? 15  VAL E CA  1 
ATOM 3554 C C   . VAL C 2 9   ? 150.097 167.892 174.475 1.00 51.28  ? 15  VAL E C   1 
ATOM 3555 O O   . VAL C 2 9   ? 150.021 169.109 174.646 1.00 51.28  ? 15  VAL E O   1 
ATOM 3556 C CB  . VAL C 2 9   ? 152.054 167.284 175.926 1.00 51.28  ? 15  VAL E CB  1 
ATOM 3557 C CG1 . VAL C 2 9   ? 152.843 167.471 174.641 1.00 51.28  ? 15  VAL E CG1 1 
ATOM 3558 C CG2 . VAL C 2 9   ? 152.194 168.495 176.834 1.00 51.28  ? 15  VAL E CG2 1 
ATOM 3559 N N   . HIS C 2 10  ? 149.755 167.319 173.317 1.00 53.29  ? 16  HIS E N   1 
ATOM 3560 C CA  . HIS C 2 10  ? 149.332 168.135 172.183 1.00 53.29  ? 16  HIS E CA  1 
ATOM 3561 C C   . HIS C 2 10  ? 148.079 168.936 172.502 1.00 53.29  ? 16  HIS E C   1 
ATOM 3562 O O   . HIS C 2 10  ? 147.967 170.104 172.111 1.00 53.29  ? 16  HIS E O   1 
ATOM 3563 C CB  . HIS C 2 10  ? 149.086 167.260 170.957 1.00 53.29  ? 16  HIS E CB  1 
ATOM 3564 C CG  . HIS C 2 10  ? 149.040 168.031 169.677 1.00 53.29  ? 16  HIS E CG  1 
ATOM 3565 N ND1 . HIS C 2 10  ? 149.956 169.012 169.367 1.00 53.29  ? 16  HIS E ND1 1 
ATOM 3566 C CD2 . HIS C 2 10  ? 148.170 167.987 168.642 1.00 53.29  ? 16  HIS E CD2 1 
ATOM 3567 C CE1 . HIS C 2 10  ? 149.663 169.527 168.187 1.00 53.29  ? 16  HIS E CE1 1 
ATOM 3568 N NE2 . HIS C 2 10  ? 148.583 168.923 167.726 1.00 53.29  ? 16  HIS E NE2 1 
ATOM 3569 N N   . SER C 2 11  ? 147.118 168.322 173.189 1.00 49.55  ? 17  SER E N   1 
ATOM 3570 C CA  . SER C 2 11  ? 145.858 168.999 173.470 1.00 49.55  ? 17  SER E CA  1 
ATOM 3571 C C   . SER C 2 11  ? 146.083 170.248 174.314 1.00 49.55  ? 17  SER E C   1 
ATOM 3572 O O   . SER C 2 11  ? 145.579 171.332 173.995 1.00 49.55  ? 17  SER E O   1 
ATOM 3573 C CB  . SER C 2 11  ? 144.901 168.032 174.166 1.00 49.55  ? 17  SER E CB  1 
ATOM 3574 O OG  . SER C 2 11  ? 144.780 166.827 173.433 1.00 49.55  ? 17  SER E OG  1 
ATOM 3575 N N   . THR C 2 12  ? 146.859 170.117 175.392 1.00 51.13  ? 18  THR E N   1 
ATOM 3576 C CA  . THR C 2 12  ? 147.101 171.260 176.265 1.00 51.13  ? 18  THR E CA  1 
ATOM 3577 C C   . THR C 2 12  ? 147.867 172.366 175.553 1.00 51.13  ? 18  THR E C   1 
ATOM 3578 O O   . THR C 2 12  ? 147.520 173.543 175.694 1.00 51.13  ? 18  THR E O   1 
ATOM 3579 C CB  . THR C 2 12  ? 147.857 170.821 177.517 1.00 51.13  ? 18  THR E CB  1 
ATOM 3580 O OG1 . THR C 2 12  ? 147.243 169.647 178.062 1.00 51.13  ? 18  THR E OG1 1 
ATOM 3581 C CG2 . THR C 2 12  ? 147.839 171.925 178.560 1.00 51.13  ? 18  THR E CG2 1 
ATOM 3582 N N   . ASN C 2 13  ? 148.903 172.019 174.788 1.00 53.19  ? 19  ASN E N   1 
ATOM 3583 C CA  . ASN C 2 13  ? 149.659 173.049 174.086 1.00 53.19  ? 19  ASN E CA  1 
ATOM 3584 C C   . ASN C 2 13  ? 148.834 173.736 173.008 1.00 53.19  ? 19  ASN E C   1 
ATOM 3585 O O   . ASN C 2 13  ? 148.933 174.958 172.851 1.00 53.19  ? 19  ASN E O   1 
ATOM 3586 C CB  . ASN C 2 13  ? 150.934 172.467 173.477 1.00 53.19  ? 19  ASN E CB  1 
ATOM 3587 C CG  . ASN C 2 13  ? 151.743 171.663 174.473 1.00 53.19  ? 19  ASN E CG  1 
ATOM 3588 O OD1 . ASN C 2 13  ? 152.273 170.602 174.146 1.00 53.19  ? 19  ASN E OD1 1 
ATOM 3589 N ND2 . ASN C 2 13  ? 151.846 172.167 175.697 1.00 53.19  ? 19  ASN E ND2 1 
ATOM 3590 N N   . VAL C 2 14  ? 148.023 172.986 172.258 1.00 51.18  ? 20  VAL E N   1 
ATOM 3591 C CA  . VAL C 2 14  ? 147.210 173.633 171.235 1.00 51.18  ? 20  VAL E CA  1 
ATOM 3592 C C   . VAL C 2 14  ? 146.156 174.522 171.881 1.00 51.18  ? 20  VAL E C   1 
ATOM 3593 O O   . VAL C 2 14  ? 145.871 175.614 171.378 1.00 51.18  ? 20  VAL E O   1 
ATOM 3594 C CB  . VAL C 2 14  ? 146.592 172.599 170.271 1.00 51.18  ? 20  VAL E CB  1 
ATOM 3595 C CG1 . VAL C 2 14  ? 145.449 171.844 170.913 1.00 51.18  ? 20  VAL E CG1 1 
ATOM 3596 C CG2 . VAL C 2 14  ? 146.124 173.283 169.001 1.00 51.18  ? 20  VAL E CG2 1 
ATOM 3597 N N   . LEU C 2 15  ? 145.587 174.104 173.017 1.00 57.27  ? 21  LEU E N   1 
ATOM 3598 C CA  . LEU C 2 15  ? 144.641 174.959 173.720 1.00 57.27  ? 21  LEU E CA  1 
ATOM 3599 C C   . LEU C 2 15  ? 145.288 176.226 174.263 1.00 57.27  ? 21  LEU E C   1 
ATOM 3600 O O   . LEU C 2 15  ? 144.709 177.308 174.125 1.00 57.27  ? 21  LEU E O   1 
ATOM 3601 C CB  . LEU C 2 15  ? 143.977 174.187 174.860 1.00 57.27  ? 21  LEU E CB  1 
ATOM 3602 C CG  . LEU C 2 15  ? 142.554 174.616 175.207 1.00 57.27  ? 21  LEU E CG  1 
ATOM 3603 C CD1 . LEU C 2 15  ? 141.801 175.032 173.958 1.00 57.27  ? 21  LEU E CD1 1 
ATOM 3604 C CD2 . LEU C 2 15  ? 141.825 173.494 175.921 1.00 57.27  ? 21  LEU E CD2 1 
ATOM 3605 N N   . LEU C 2 16  ? 146.473 176.124 174.864 1.00 55.94  ? 22  LEU E N   1 
ATOM 3606 C CA  . LEU C 2 16  ? 147.188 177.303 175.332 1.00 55.94  ? 22  LEU E CA  1 
ATOM 3607 C C   . LEU C 2 16  ? 147.595 178.241 174.207 1.00 55.94  ? 22  LEU E C   1 
ATOM 3608 O O   . LEU C 2 16  ? 147.476 179.459 174.370 1.00 55.94  ? 22  LEU E O   1 
ATOM 3609 C CB  . LEU C 2 16  ? 148.433 176.903 176.133 1.00 55.94  ? 22  LEU E CB  1 
ATOM 3610 C CG  . LEU C 2 16  ? 148.277 176.688 177.641 1.00 55.94  ? 22  LEU E CG  1 
ATOM 3611 C CD1 . LEU C 2 16  ? 147.954 178.011 178.317 1.00 55.94  ? 22  LEU E CD1 1 
ATOM 3612 C CD2 . LEU C 2 16  ? 147.217 175.654 177.978 1.00 55.94  ? 22  LEU E CD2 1 
ATOM 3613 N N   . SER C 2 17  ? 148.064 177.717 173.076 1.00 56.41  ? 23  SER E N   1 
ATOM 3614 C CA  . SER C 2 17  ? 148.384 178.565 171.939 1.00 56.41  ? 23  SER E CA  1 
ATOM 3615 C C   . SER C 2 17  ? 147.152 179.211 171.326 1.00 56.41  ? 23  SER E C   1 
ATOM 3616 O O   . SER C 2 17  ? 147.219 180.375 170.915 1.00 56.41  ? 23  SER E O   1 
ATOM 3617 C CB  . SER C 2 17  ? 149.128 177.765 170.865 1.00 56.41  ? 23  SER E CB  1 
ATOM 3618 O OG  . SER C 2 17  ? 148.628 176.444 170.770 1.00 56.41  ? 23  SER E OG  1 
ATOM 3619 N N   . LEU C 2 18  ? 146.027 178.499 171.280 1.00 59.02  ? 24  LEU E N   1 
ATOM 3620 C CA  . LEU C 2 18  ? 144.778 179.108 170.856 1.00 59.02  ? 24  LEU E CA  1 
ATOM 3621 C C   . LEU C 2 18  ? 144.322 180.200 171.814 1.00 59.02  ? 24  LEU E C   1 
ATOM 3622 O O   . LEU C 2 18  ? 143.798 181.219 171.361 1.00 59.02  ? 24  LEU E O   1 
ATOM 3623 C CB  . LEU C 2 18  ? 143.706 178.027 170.716 1.00 59.02  ? 24  LEU E CB  1 
ATOM 3624 C CG  . LEU C 2 18  ? 142.691 178.182 169.584 1.00 59.02  ? 24  LEU E CG  1 
ATOM 3625 C CD1 . LEU C 2 18  ? 141.957 176.873 169.363 1.00 59.02  ? 24  LEU E CD1 1 
ATOM 3626 C CD2 . LEU C 2 18  ? 141.711 179.300 169.866 1.00 59.02  ? 24  LEU E CD2 1 
ATOM 3627 N N   . ASN C 2 19  ? 144.519 180.021 173.120 1.00 60.83  ? 25  ASN E N   1 
ATOM 3628 C CA  . ASN C 2 19  ? 144.260 181.077 174.091 1.00 60.83  ? 25  ASN E CA  1 
ATOM 3629 C C   . ASN C 2 19  ? 145.159 182.292 173.902 1.00 60.83  ? 25  ASN E C   1 
ATOM 3630 O O   . ASN C 2 19  ? 144.683 183.425 174.037 1.00 60.83  ? 25  ASN E O   1 
ATOM 3631 C CB  . ASN C 2 19  ? 144.429 180.536 175.516 1.00 60.83  ? 25  ASN E CB  1 
ATOM 3632 C CG  . ASN C 2 19  ? 144.342 181.620 176.565 1.00 60.83  ? 25  ASN E CG  1 
ATOM 3633 O OD1 . ASN C 2 19  ? 143.417 182.429 176.563 1.00 60.83  ? 25  ASN E OD1 1 
ATOM 3634 N ND2 . ASN C 2 19  ? 145.306 181.637 177.477 1.00 60.83  ? 25  ASN E ND2 1 
ATOM 3635 N N   . ASP C 2 20  ? 146.441 182.084 173.596 1.00 63.27  ? 26  ASP E N   1 
ATOM 3636 C CA  . ASP C 2 20  ? 147.317 183.200 173.260 1.00 63.27  ? 26  ASP E CA  1 
ATOM 3637 C C   . ASP C 2 20  ? 146.832 183.920 172.010 1.00 63.27  ? 26  ASP E C   1 
ATOM 3638 O O   . ASP C 2 20  ? 146.874 185.153 171.942 1.00 63.27  ? 26  ASP E O   1 
ATOM 3639 C CB  . ASP C 2 20  ? 148.750 182.703 173.068 1.00 63.27  ? 26  ASP E CB  1 
ATOM 3640 C CG  . ASP C 2 20  ? 149.602 182.889 174.307 1.00 63.27  ? 26  ASP E CG  1 
ATOM 3641 O OD1 . ASP C 2 20  ? 149.171 183.617 175.226 1.00 63.27  ? 26  ASP E OD1 1 
ATOM 3642 O OD2 . ASP C 2 20  ? 150.706 182.306 174.361 1.00 63.27  ? 26  ASP E OD2 1 
ATOM 3643 N N   . GLN C 2 21  ? 146.374 183.161 171.013 1.00 69.22  ? 27  GLN E N   1 
ATOM 3644 C CA  . GLN C 2 21  ? 145.778 183.771 169.830 1.00 69.22  ? 27  GLN E CA  1 
ATOM 3645 C C   . GLN C 2 21  ? 144.555 184.597 170.206 1.00 69.22  ? 27  GLN E C   1 
ATOM 3646 O O   . GLN C 2 21  ? 144.365 185.709 169.700 1.00 69.22  ? 27  GLN E O   1 
ATOM 3647 C CB  . GLN C 2 21  ? 145.404 182.685 168.824 1.00 69.22  ? 27  GLN E CB  1 
ATOM 3648 C CG  . GLN C 2 21  ? 146.584 182.128 168.051 1.00 69.22  ? 27  GLN E CG  1 
ATOM 3649 C CD  . GLN C 2 21  ? 146.161 181.308 166.853 1.00 69.22  ? 27  GLN E CD  1 
ATOM 3650 O OE1 . GLN C 2 21  ? 145.346 181.742 166.045 1.00 69.22  ? 27  GLN E OE1 1 
ATOM 3651 N NE2 . GLN C 2 21  ? 146.708 180.105 166.740 1.00 69.22  ? 27  GLN E NE2 1 
ATOM 3652 N N   . ARG C 2 22  ? 143.721 184.070 171.100 1.00 67.78  ? 28  ARG E N   1 
ATOM 3653 C CA  . ARG C 2 22  ? 142.557 184.742 171.671 1.00 67.78  ? 28  ARG E CA  1 
ATOM 3654 C C   . ARG C 2 22  ? 142.911 186.053 172.304 1.00 67.78  ? 28  ARG E C   1 
ATOM 3655 O O   . ARG C 2 22  ? 142.185 187.038 172.136 1.00 67.78  ? 28  ARG E O   1 
ATOM 3656 C CB  . ARG C 2 22  ? 141.887 183.820 172.696 1.00 67.78  ? 28  ARG E CB  1 
ATOM 3657 C CG  . ARG C 2 22  ? 140.424 184.129 173.015 1.00 67.78  ? 28  ARG E CG  1 
ATOM 3658 C CD  . ARG C 2 22  ? 140.264 185.294 173.980 1.00 67.78  ? 28  ARG E CD  1 
ATOM 3659 N NE  . ARG C 2 22  ? 141.050 185.125 175.194 1.00 67.78  ? 28  ARG E NE  1 
ATOM 3660 C CZ  . ARG C 2 22  ? 140.702 184.344 176.206 1.00 67.78  ? 28  ARG E CZ  1 
ATOM 3661 N NH1 . ARG C 2 22  ? 139.588 183.632 176.177 1.00 67.78  ? 28  ARG E NH1 1 
ATOM 3662 N NH2 . ARG C 2 22  ? 141.490 184.276 177.275 1.00 67.78  ? 28  ARG E NH2 1 
ATOM 3663 N N   . LYS C 2 23  ? 144.029 186.100 173.023 1.00 68.44  ? 29  LYS E N   1 
ATOM 3664 C CA  . LYS C 2 23  ? 144.453 187.341 173.656 1.00 68.44  ? 29  LYS E CA  1 
ATOM 3665 C C   . LYS C 2 23  ? 145.200 188.280 172.723 1.00 68.44  ? 29  LYS E C   1 
ATOM 3666 O O   . LYS C 2 23  ? 145.577 189.370 173.164 1.00 68.44  ? 29  LYS E O   1 
ATOM 3667 C CB  . LYS C 2 23  ? 145.338 187.046 174.875 1.00 68.44  ? 29  LYS E CB  1 
ATOM 3668 C CG  . LYS C 2 23  ? 144.584 187.007 176.193 1.00 68.44  ? 29  LYS E CG  1 
ATOM 3669 C CD  . LYS C 2 23  ? 145.539 187.001 177.373 1.00 68.44  ? 29  LYS E CD  1 
ATOM 3670 C CE  . LYS C 2 23  ? 145.398 185.731 178.191 1.00 68.44  ? 29  LYS E CE  1 
ATOM 3671 N NZ  . LYS C 2 23  ? 146.284 185.745 179.385 1.00 68.44  ? 29  LYS E NZ  1 
ATOM 3672 N N   . LYS C 2 24  ? 145.430 187.911 171.463 1.00 81.28  ? 30  LYS E N   1 
ATOM 3673 C CA  . LYS C 2 24  ? 146.203 188.728 170.528 1.00 81.28  ? 30  LYS E CA  1 
ATOM 3674 C C   . LYS C 2 24  ? 145.480 188.796 169.183 1.00 81.28  ? 30  LYS E C   1 
ATOM 3675 O O   . LYS C 2 24  ? 145.774 188.008 168.280 1.00 81.28  ? 30  LYS E O   1 
ATOM 3676 C CB  . LYS C 2 24  ? 147.613 188.163 170.382 1.00 81.28  ? 30  LYS E CB  1 
ATOM 3677 C CG  . LYS C 2 24  ? 148.612 189.104 169.733 1.00 81.28  ? 30  LYS E CG  1 
ATOM 3678 C CD  . LYS C 2 24  ? 150.015 188.885 170.283 1.00 81.28  ? 30  LYS E CD  1 
ATOM 3679 C CE  . LYS C 2 24  ? 150.325 187.407 170.493 1.00 81.28  ? 30  LYS E CE  1 
ATOM 3680 N NZ  . LYS C 2 24  ? 150.201 186.613 169.238 1.00 81.28  ? 30  LYS E NZ  1 
ATOM 3681 N N   . ASP C 2 25  ? 144.544 189.743 169.069 1.00 92.38  ? 31  ASP E N   1 
ATOM 3682 C CA  . ASP C 2 25  ? 143.942 190.189 167.813 1.00 92.38  ? 31  ASP E CA  1 
ATOM 3683 C C   . ASP C 2 25  ? 143.719 189.095 166.773 1.00 92.38  ? 31  ASP E C   1 
ATOM 3684 O O   . ASP C 2 25  ? 142.586 188.661 166.543 1.00 92.38  ? 31  ASP E O   1 
ATOM 3685 C CB  . ASP C 2 25  ? 144.808 191.286 167.190 1.00 92.38  ? 31  ASP E CB  1 
ATOM 3686 C CG  . ASP C 2 25  ? 145.121 192.403 168.162 1.00 92.38  ? 31  ASP E CG  1 
ATOM 3687 O OD1 . ASP C 2 25  ? 144.188 192.884 168.839 1.00 92.38  ? 31  ASP E OD1 1 
ATOM 3688 O OD2 . ASP C 2 25  ? 146.302 192.799 168.250 1.00 92.38  ? 31  ASP E OD2 1 
ATOM 3689 N N   . VAL C 2 26  ? 144.810 188.657 166.140 1.00 91.46  ? 32  VAL E N   1 
ATOM 3690 C CA  . VAL C 2 26  ? 144.734 187.896 164.897 1.00 91.46  ? 32  VAL E CA  1 
ATOM 3691 C C   . VAL C 2 26  ? 144.022 186.560 165.101 1.00 91.46  ? 32  VAL E C   1 
ATOM 3692 O O   . VAL C 2 26  ? 143.991 185.988 166.198 1.00 91.46  ? 32  VAL E O   1 
ATOM 3693 C CB  . VAL C 2 26  ? 146.146 187.699 164.324 1.00 91.46  ? 32  VAL E CB  1 
ATOM 3694 C CG1 . VAL C 2 26  ? 146.804 189.045 164.087 1.00 91.46  ? 32  VAL E CG1 1 
ATOM 3695 C CG2 . VAL C 2 26  ? 146.990 186.894 165.295 1.00 91.46  ? 32  VAL E CG2 1 
ATOM 3696 N N   . LEU C 2 27  ? 143.421 186.073 164.010 1.00 86.54  ? 33  LEU E N   1 
ATOM 3697 C CA  . LEU C 2 27  ? 142.687 184.809 163.946 1.00 86.54  ? 33  LEU E CA  1 
ATOM 3698 C C   . LEU C 2 27  ? 141.470 184.765 164.862 1.00 86.54  ? 33  LEU E C   1 
ATOM 3699 O O   . LEU C 2 27  ? 140.844 183.711 165.010 1.00 86.54  ? 33  LEU E O   1 
ATOM 3700 C CB  . LEU C 2 27  ? 143.592 183.608 164.242 1.00 86.54  ? 33  LEU E CB  1 
ATOM 3701 C CG  . LEU C 2 27  ? 144.762 183.248 163.317 1.00 86.54  ? 33  LEU E CG  1 
ATOM 3702 C CD1 . LEU C 2 27  ? 144.244 182.990 161.914 1.00 86.54  ? 33  LEU E CD1 1 
ATOM 3703 C CD2 . LEU C 2 27  ? 145.892 184.252 163.301 1.00 86.54  ? 33  LEU E CD2 1 
ATOM 3704 N N   . CYS C 2 28  ? 141.120 185.887 165.479 1.00 88.83  ? 34  CYS E N   1 
ATOM 3705 C CA  . CYS C 2 28  ? 139.876 185.953 166.229 1.00 88.83  ? 34  CYS E CA  1 
ATOM 3706 C C   . CYS C 2 28  ? 138.768 186.508 165.343 1.00 88.83  ? 34  CYS E C   1 
ATOM 3707 O O   . CYS C 2 28  ? 138.917 187.566 164.724 1.00 88.83  ? 34  CYS E O   1 
ATOM 3708 C CB  . CYS C 2 28  ? 140.053 186.814 167.474 1.00 88.83  ? 34  CYS E CB  1 
ATOM 3709 S SG  . CYS C 2 28  ? 140.397 185.879 168.981 1.00 88.83  ? 34  CYS E SG  1 
ATOM 3710 N N   . ASP C 2 29  ? 137.650 185.790 165.283 1.00 84.17  ? 35  ASP E N   1 
ATOM 3711 C CA  . ASP C 2 29  ? 136.619 186.050 164.283 1.00 84.17  ? 35  ASP E CA  1 
ATOM 3712 C C   . ASP C 2 29  ? 135.227 186.047 164.910 1.00 84.17  ? 35  ASP E C   1 
ATOM 3713 O O   . ASP C 2 29  ? 134.245 185.632 164.295 1.00 84.17  ? 35  ASP E O   1 
ATOM 3714 C CB  . ASP C 2 29  ? 136.723 185.028 163.154 1.00 84.17  ? 35  ASP E CB  1 
ATOM 3715 C CG  . ASP C 2 29  ? 137.137 183.659 163.651 1.00 84.17  ? 35  ASP E CG  1 
ATOM 3716 O OD1 . ASP C 2 29  ? 136.958 183.388 164.856 1.00 84.17  ? 35  ASP E OD1 1 
ATOM 3717 O OD2 . ASP C 2 29  ? 137.651 182.858 162.842 1.00 84.17  ? 35  ASP E OD2 1 
ATOM 3718 N N   . VAL C 2 30  ? 135.131 186.523 166.151 1.00 85.96  ? 36  VAL E N   1 
ATOM 3719 C CA  . VAL C 2 30  ? 133.843 186.758 166.797 1.00 85.96  ? 36  VAL E CA  1 
ATOM 3720 C C   . VAL C 2 30  ? 134.064 187.654 168.007 1.00 85.96  ? 36  VAL E C   1 
ATOM 3721 O O   . VAL C 2 30  ? 135.099 187.568 168.679 1.00 85.96  ? 36  VAL E O   1 
ATOM 3722 C CB  . VAL C 2 30  ? 133.150 185.440 167.198 1.00 85.96  ? 36  VAL E CB  1 
ATOM 3723 C CG1 . VAL C 2 30  ? 134.020 184.635 168.136 1.00 85.96  ? 36  VAL E CG1 1 
ATOM 3724 C CG2 . VAL C 2 30  ? 131.781 185.702 167.816 1.00 85.96  ? 36  VAL E CG2 1 
ATOM 3725 N N   . THR C 2 31  ? 133.102 188.528 168.287 1.00 91.50  ? 37  THR E N   1 
ATOM 3726 C CA  . THR C 2 31  ? 133.202 189.438 169.422 1.00 91.50  ? 37  THR E CA  1 
ATOM 3727 C C   . THR C 2 31  ? 131.974 189.260 170.298 1.00 91.50  ? 37  THR E C   1 
ATOM 3728 O O   . THR C 2 31  ? 130.849 189.234 169.791 1.00 91.50  ? 37  THR E O   1 
ATOM 3729 C CB  . THR C 2 31  ? 133.331 190.886 168.954 1.00 91.50  ? 37  THR E CB  1 
ATOM 3730 O OG1 . THR C 2 31  ? 132.290 191.178 168.014 1.00 91.50  ? 37  THR E OG1 1 
ATOM 3731 C CG2 . THR C 2 31  ? 134.681 191.099 168.288 1.00 91.50  ? 37  THR E CG2 1 
ATOM 3732 N N   . ILE C 2 32  ? 132.191 189.133 171.605 1.00 96.20  ? 38  ILE E N   1 
ATOM 3733 C CA  . ILE C 2 32  ? 131.111 188.929 172.564 1.00 96.20  ? 38  ILE E CA  1 
ATOM 3734 C C   . ILE C 2 32  ? 130.819 190.282 173.206 1.00 96.20  ? 38  ILE E C   1 
ATOM 3735 O O   . ILE C 2 32  ? 131.506 190.703 174.138 1.00 96.20  ? 38  ILE E O   1 
ATOM 3736 C CB  . ILE C 2 32  ? 131.473 187.878 173.615 1.00 96.20  ? 38  ILE E CB  1 
ATOM 3737 C CG1 . ILE C 2 32  ? 132.272 186.729 172.997 1.00 96.20  ? 38  ILE E CG1 1 
ATOM 3738 C CG2 . ILE C 2 32  ? 130.218 187.343 174.276 1.00 96.20  ? 38  ILE E CG2 1 
ATOM 3739 C CD1 . ILE C 2 32  ? 131.580 186.027 171.856 1.00 96.20  ? 38  ILE E CD1 1 
ATOM 3740 N N   . PHE C 2 33  ? 129.795 190.967 172.705 1.00 107.11 ? 39  PHE E N   1 
ATOM 3741 C CA  . PHE C 2 33  ? 129.356 192.231 173.289 1.00 107.11 ? 39  PHE E CA  1 
ATOM 3742 C C   . PHE C 2 33  ? 128.538 191.933 174.539 1.00 107.11 ? 39  PHE E C   1 
ATOM 3743 O O   . PHE C 2 33  ? 127.395 191.475 174.445 1.00 107.11 ? 39  PHE E O   1 
ATOM 3744 C CB  . PHE C 2 33  ? 128.541 193.031 172.278 1.00 107.11 ? 39  PHE E CB  1 
ATOM 3745 C CG  . PHE C 2 33  ? 128.924 194.480 172.197 1.00 107.11 ? 39  PHE E CG  1 
ATOM 3746 C CD1 . PHE C 2 33  ? 130.180 194.859 171.758 1.00 107.11 ? 39  PHE E CD1 1 
ATOM 3747 C CD2 . PHE C 2 33  ? 128.019 195.465 172.555 1.00 107.11 ? 39  PHE E CD2 1 
ATOM 3748 C CE1 . PHE C 2 33  ? 130.527 196.195 171.684 1.00 107.11 ? 39  PHE E CE1 1 
ATOM 3749 C CE2 . PHE C 2 33  ? 128.360 196.801 172.482 1.00 107.11 ? 39  PHE E CE2 1 
ATOM 3750 C CZ  . PHE C 2 33  ? 129.616 197.167 172.046 1.00 107.11 ? 39  PHE E CZ  1 
ATOM 3751 N N   . VAL C 2 34  ? 129.119 192.182 175.711 1.00 109.86 ? 40  VAL E N   1 
ATOM 3752 C CA  . VAL C 2 34  ? 128.464 191.909 176.983 1.00 109.86 ? 40  VAL E CA  1 
ATOM 3753 C C   . VAL C 2 34  ? 128.502 193.157 177.852 1.00 109.86 ? 40  VAL E C   1 
ATOM 3754 O O   . VAL C 2 34  ? 129.579 193.646 178.211 1.00 109.86 ? 40  VAL E O   1 
ATOM 3755 C CB  . VAL C 2 34  ? 129.117 190.718 177.715 1.00 109.86 ? 40  VAL E CB  1 
ATOM 3756 C CG1 . VAL C 2 34  ? 128.635 190.652 179.154 1.00 109.86 ? 40  VAL E CG1 1 
ATOM 3757 C CG2 . VAL C 2 34  ? 128.804 189.421 176.991 1.00 109.86 ? 40  VAL E CG2 1 
ATOM 3758 N N   . GLU C 2 35  ? 127.316 193.672 178.180 1.00 111.86 ? 41  GLU E N   1 
ATOM 3759 C CA  . GLU C 2 35  ? 127.125 194.717 179.189 1.00 111.86 ? 41  GLU E CA  1 
ATOM 3760 C C   . GLU C 2 35  ? 127.889 195.999 178.870 1.00 111.86 ? 41  GLU E C   1 
ATOM 3761 O O   . GLU C 2 35  ? 128.117 196.826 179.758 1.00 111.86 ? 41  GLU E O   1 
ATOM 3762 C CB  . GLU C 2 35  ? 127.508 194.207 180.581 1.00 111.86 ? 41  GLU E CB  1 
ATOM 3763 C CG  . GLU C 2 35  ? 126.445 193.334 181.217 1.00 111.86 ? 41  GLU E CG  1 
ATOM 3764 C CD  . GLU C 2 35  ? 127.013 192.391 182.253 1.00 111.86 ? 41  GLU E CD  1 
ATOM 3765 O OE1 . GLU C 2 35  ? 127.600 192.873 183.244 1.00 111.86 ? 41  GLU E OE1 1 
ATOM 3766 O OE2 . GLU C 2 35  ? 126.884 191.164 182.066 1.00 111.86 ? 41  GLU E OE2 1 
ATOM 3767 N N   . GLY C 2 36  ? 128.284 196.193 177.616 1.00 113.10 ? 42  GLY E N   1 
ATOM 3768 C CA  . GLY C 2 36  ? 128.968 197.413 177.237 1.00 113.10 ? 42  GLY E CA  1 
ATOM 3769 C C   . GLY C 2 36  ? 130.423 197.223 176.862 1.00 113.10 ? 42  GLY E C   1 
ATOM 3770 O O   . GLY C 2 36  ? 130.903 197.844 175.908 1.00 113.10 ? 42  GLY E O   1 
ATOM 3771 N N   . GLN C 2 37  ? 131.139 196.377 177.597 1.00 111.23 ? 43  GLN E N   1 
ATOM 3772 C CA  . GLN C 2 37  ? 132.536 196.106 177.291 1.00 111.23 ? 43  GLN E CA  1 
ATOM 3773 C C   . GLN C 2 37  ? 132.610 195.027 176.210 1.00 111.23 ? 43  GLN E C   1 
ATOM 3774 O O   . GLN C 2 37  ? 131.607 194.389 175.879 1.00 111.23 ? 43  GLN E O   1 
ATOM 3775 C CB  . GLN C 2 37  ? 133.310 195.727 178.563 1.00 111.23 ? 43  GLN E CB  1 
ATOM 3776 C CG  . GLN C 2 37  ? 133.097 196.628 179.787 1.00 111.23 ? 43  GLN E CG  1 
ATOM 3777 C CD  . GLN C 2 37  ? 131.755 196.438 180.474 1.00 111.23 ? 43  GLN E CD  1 
ATOM 3778 O OE1 . GLN C 2 37  ? 130.759 196.094 179.841 1.00 111.23 ? 43  GLN E OE1 1 
ATOM 3779 N NE2 . GLN C 2 37  ? 131.726 196.670 181.781 1.00 111.23 ? 43  GLN E NE2 1 
ATOM 3780 N N   . ARG C 2 38  ? 133.799 194.804 175.659 1.00 104.18 ? 44  ARG E N   1 
ATOM 3781 C CA  . ARG C 2 38  ? 133.987 193.941 174.506 1.00 104.18 ? 44  ARG E CA  1 
ATOM 3782 C C   . ARG C 2 38  ? 134.767 192.703 174.920 1.00 104.18 ? 44  ARG E C   1 
ATOM 3783 O O   . ARG C 2 38  ? 135.694 192.764 175.732 1.00 104.18 ? 44  ARG E O   1 
ATOM 3784 C CB  . ARG C 2 38  ? 134.727 194.683 173.383 1.00 104.18 ? 44  ARG E CB  1 
ATOM 3785 C CG  . ARG C 2 38  ? 133.950 195.841 172.773 1.00 104.18 ? 44  ARG E CG  1 
ATOM 3786 C CD  . ARG C 2 38  ? 134.620 196.359 171.507 1.00 104.18 ? 44  ARG E CD  1 
ATOM 3787 N NE  . ARG C 2 38  ? 134.724 195.352 170.458 1.00 104.18 ? 44  ARG E NE  1 
ATOM 3788 C CZ  . ARG C 2 38  ? 133.808 195.149 169.521 1.00 104.18 ? 44  ARG E CZ  1 
ATOM 3789 N NH1 . ARG C 2 38  ? 132.703 195.875 169.466 1.00 104.18 ? 44  ARG E NH1 1 
ATOM 3790 N NH2 . ARG C 2 38  ? 134.013 194.204 168.607 1.00 104.18 ? 44  ARG E NH2 1 
ATOM 3791 N N   . PHE C 2 39  ? 134.380 191.568 174.349 1.00 97.55  ? 45  PHE E N   1 
ATOM 3792 C CA  . PHE C 2 39  ? 135.133 190.335 174.512 1.00 97.55  ? 45  PHE E CA  1 
ATOM 3793 C C   . PHE C 2 39  ? 135.247 189.681 173.147 1.00 97.55  ? 45  PHE E C   1 
ATOM 3794 O O   . PHE C 2 39  ? 134.265 189.583 172.409 1.00 97.55  ? 45  PHE E O   1 
ATOM 3795 C CB  . PHE C 2 39  ? 134.471 189.381 175.512 1.00 97.55  ? 45  PHE E CB  1 
ATOM 3796 C CG  . PHE C 2 39  ? 134.666 189.777 176.944 1.00 97.55  ? 45  PHE E CG  1 
ATOM 3797 C CD1 . PHE C 2 39  ? 135.929 190.054 177.433 1.00 97.55  ? 45  PHE E CD1 1 
ATOM 3798 C CD2 . PHE C 2 39  ? 133.586 189.869 177.802 1.00 97.55  ? 45  PHE E CD2 1 
ATOM 3799 C CE1 . PHE C 2 39  ? 136.110 190.422 178.750 1.00 97.55  ? 45  PHE E CE1 1 
ATOM 3800 C CE2 . PHE C 2 39  ? 133.760 190.234 179.119 1.00 97.55  ? 45  PHE E CE2 1 
ATOM 3801 C CZ  . PHE C 2 39  ? 135.024 190.511 179.594 1.00 97.55  ? 45  PHE E CZ  1 
ATOM 3802 N N   . ARG C 2 40  ? 136.454 189.237 172.818 1.00 83.77  ? 46  ARG E N   1 
ATOM 3803 C CA  . ARG C 2 40  ? 136.748 188.710 171.498 1.00 83.77  ? 46  ARG E CA  1 
ATOM 3804 C C   . ARG C 2 40  ? 137.288 187.294 171.633 1.00 83.77  ? 46  ARG E C   1 
ATOM 3805 O O   . ARG C 2 40  ? 138.129 187.009 172.487 1.00 83.77  ? 46  ARG E O   1 
ATOM 3806 C CB  . ARG C 2 40  ? 137.737 189.625 170.765 1.00 83.77  ? 46  ARG E CB  1 
ATOM 3807 C CG  . ARG C 2 40  ? 138.516 188.967 169.661 1.00 83.77  ? 46  ARG E CG  1 
ATOM 3808 C CD  . ARG C 2 40  ? 138.874 189.974 168.581 1.00 83.77  ? 46  ARG E CD  1 
ATOM 3809 N NE  . ARG C 2 40  ? 137.850 190.040 167.546 1.00 83.77  ? 46  ARG E NE  1 
ATOM 3810 C CZ  . ARG C 2 40  ? 138.016 190.616 166.363 1.00 83.77  ? 46  ARG E CZ  1 
ATOM 3811 N NH1 . ARG C 2 40  ? 139.157 191.196 166.032 1.00 83.77  ? 46  ARG E NH1 1 
ATOM 3812 N NH2 . ARG C 2 40  ? 137.012 190.608 165.492 1.00 83.77  ? 46  ARG E NH2 1 
ATOM 3813 N N   . ALA C 2 41  ? 136.789 186.402 170.782 1.00 76.27  ? 47  ALA E N   1 
ATOM 3814 C CA  . ALA C 2 41  ? 137.054 184.973 170.918 1.00 76.27  ? 47  ALA E CA  1 
ATOM 3815 C C   . ALA C 2 41  ? 137.075 184.344 169.529 1.00 76.27  ? 47  ALA E C   1 
ATOM 3816 O O   . ALA C 2 41  ? 137.215 185.037 168.516 1.00 76.27  ? 47  ALA E O   1 
ATOM 3817 C CB  . ALA C 2 41  ? 136.016 184.314 171.831 1.00 76.27  ? 47  ALA E CB  1 
ATOM 3818 N N   . HIS C 2 42  ? 136.945 183.020 169.484 1.00 77.00  ? 48  HIS E N   1 
ATOM 3819 C CA  . HIS C 2 42  ? 136.973 182.251 168.246 1.00 77.00  ? 48  HIS E CA  1 
ATOM 3820 C C   . HIS C 2 42  ? 135.607 181.627 167.998 1.00 77.00  ? 48  HIS E C   1 
ATOM 3821 O O   . HIS C 2 42  ? 134.831 181.427 168.939 1.00 77.00  ? 48  HIS E O   1 
ATOM 3822 C CB  . HIS C 2 42  ? 138.043 181.160 168.309 1.00 77.00  ? 48  HIS E CB  1 
ATOM 3823 C CG  . HIS C 2 42  ? 139.443 181.685 168.313 1.00 77.00  ? 48  HIS E CG  1 
ATOM 3824 N ND1 . HIS C 2 42  ? 140.264 181.626 167.209 1.00 77.00  ? 48  HIS E ND1 1 
ATOM 3825 C CD2 . HIS C 2 42  ? 140.165 182.288 169.287 1.00 77.00  ? 48  HIS E CD2 1 
ATOM 3826 C CE1 . HIS C 2 42  ? 141.434 182.164 167.503 1.00 77.00  ? 48  HIS E CE1 1 
ATOM 3827 N NE2 . HIS C 2 42  ? 141.400 182.573 168.758 1.00 77.00  ? 48  HIS E NE2 1 
ATOM 3828 N N   . ARG C 2 43  ? 135.316 181.320 166.734 1.00 77.01  ? 49  ARG E N   1 
ATOM 3829 C CA  . ARG C 2 43  ? 134.039 180.714 166.354 1.00 77.01  ? 49  ARG E CA  1 
ATOM 3830 C C   . ARG C 2 43  ? 134.166 179.193 166.257 1.00 77.01  ? 49  ARG E C   1 
ATOM 3831 O O   . ARG C 2 43  ? 133.349 178.506 165.647 1.00 77.01  ? 49  ARG E O   1 
ATOM 3832 C CB  . ARG C 2 43  ? 133.537 181.303 165.041 1.00 77.01  ? 49  ARG E CB  1 
ATOM 3833 C CG  . ARG C 2 43  ? 132.868 182.651 165.181 1.00 77.01  ? 49  ARG E CG  1 
ATOM 3834 C CD  . ARG C 2 43  ? 132.181 183.092 163.897 1.00 77.01  ? 49  ARG E CD  1 
ATOM 3835 N NE  . ARG C 2 43  ? 133.064 183.022 162.741 1.00 77.01  ? 49  ARG E NE  1 
ATOM 3836 C CZ  . ARG C 2 43  ? 132.880 182.209 161.710 1.00 77.01  ? 49  ARG E CZ  1 
ATOM 3837 N NH1 . ARG C 2 43  ? 131.846 181.388 161.655 1.00 77.01  ? 49  ARG E NH1 1 
ATOM 3838 N NH2 . ARG C 2 43  ? 133.753 182.224 160.707 1.00 77.01  ? 49  ARG E NH2 1 
ATOM 3839 N N   . SER C 2 44  ? 135.219 178.667 166.875 1.00 71.44  ? 50  SER E N   1 
ATOM 3840 C CA  . SER C 2 44  ? 135.444 177.230 166.828 1.00 71.44  ? 50  SER E CA  1 
ATOM 3841 C C   . SER C 2 44  ? 135.451 176.641 168.231 1.00 71.44  ? 50  SER E C   1 
ATOM 3842 O O   . SER C 2 44  ? 134.867 175.580 168.469 1.00 71.44  ? 50  SER E O   1 
ATOM 3843 C CB  . SER C 2 44  ? 136.756 176.919 166.109 1.00 71.44  ? 50  SER E CB  1 
ATOM 3844 O OG  . SER C 2 44  ? 136.715 175.638 165.506 1.00 71.44  ? 50  SER E OG  1 
ATOM 3845 N N   . VAL C 2 45  ? 136.109 177.326 169.168 1.00 74.71  ? 51  VAL E N   1 
ATOM 3846 C CA  . VAL C 2 45  ? 136.128 176.855 170.551 1.00 74.71  ? 51  VAL E CA  1 
ATOM 3847 C C   . VAL C 2 45  ? 134.752 177.006 171.183 1.00 74.71  ? 51  VAL E C   1 
ATOM 3848 O O   . VAL C 2 45  ? 134.234 176.075 171.812 1.00 74.71  ? 51  VAL E O   1 
ATOM 3849 C CB  . VAL C 2 45  ? 137.205 177.605 171.355 1.00 74.71  ? 51  VAL E CB  1 
ATOM 3850 C CG1 . VAL C 2 45  ? 137.612 176.799 172.577 1.00 74.71  ? 51  VAL E CG1 1 
ATOM 3851 C CG2 . VAL C 2 45  ? 138.405 177.891 170.477 1.00 74.71  ? 51  VAL E CG2 1 
ATOM 3852 N N   . LEU C 2 46  ? 134.130 178.173 171.010 1.00 77.23  ? 52  LEU E N   1 
ATOM 3853 C CA  . LEU C 2 46  ? 132.834 178.451 171.618 1.00 77.23  ? 52  LEU E CA  1 
ATOM 3854 C C   . LEU C 2 46  ? 131.726 177.549 171.098 1.00 77.23  ? 52  LEU E C   1 
ATOM 3855 O O   . LEU C 2 46  ? 130.695 177.423 171.767 1.00 77.23  ? 52  LEU E O   1 
ATOM 3856 C CB  . LEU C 2 46  ? 132.449 179.916 171.400 1.00 77.23  ? 52  LEU E CB  1 
ATOM 3857 C CG  . LEU C 2 46  ? 132.925 180.922 172.450 1.00 77.23  ? 52  LEU E CG  1 
ATOM 3858 C CD1 . LEU C 2 46  ? 134.437 181.014 172.492 1.00 77.23  ? 52  LEU E CD1 1 
ATOM 3859 C CD2 . LEU C 2 46  ? 132.314 182.285 172.191 1.00 77.23  ? 52  LEU E CD2 1 
ATOM 3860 N N   . ALA C 2 47  ? 131.906 176.917 169.942 1.00 72.85  ? 53  ALA E N   1 
ATOM 3861 C CA  . ALA C 2 47  ? 130.915 175.977 169.440 1.00 72.85  ? 53  ALA E CA  1 
ATOM 3862 C C   . ALA C 2 47  ? 131.275 174.568 169.885 1.00 72.85  ? 53  ALA E C   1 
ATOM 3863 O O   . ALA C 2 47  ? 130.758 173.585 169.346 1.00 72.85  ? 53  ALA E O   1 
ATOM 3864 C CB  . ALA C 2 47  ? 130.818 176.054 167.916 1.00 72.85  ? 53  ALA E CB  1 
ATOM 3865 N N   . ALA C 2 48  ? 132.162 174.463 170.874 1.00 77.77  ? 54  ALA E N   1 
ATOM 3866 C CA  . ALA C 2 48  ? 132.616 173.168 171.360 1.00 77.77  ? 54  ALA E CA  1 
ATOM 3867 C C   . ALA C 2 48  ? 132.527 173.091 172.878 1.00 77.77  ? 54  ALA E C   1 
ATOM 3868 O O   . ALA C 2 48  ? 132.475 171.997 173.448 1.00 77.77  ? 54  ALA E O   1 
ATOM 3869 C CB  . ALA C 2 48  ? 134.050 172.901 170.901 1.00 77.77  ? 54  ALA E CB  1 
ATOM 3870 N N   . CYS C 2 49  ? 132.509 174.248 173.541 1.00 87.67  ? 55  CYS E N   1 
ATOM 3871 C CA  . CYS C 2 49  ? 132.475 174.266 174.997 1.00 87.67  ? 55  CYS E CA  1 
ATOM 3872 C C   . CYS C 2 49  ? 131.064 174.143 175.554 1.00 87.67  ? 55  CYS E C   1 
ATOM 3873 O O   . CYS C 2 49  ? 130.898 173.657 176.677 1.00 87.67  ? 55  CYS E O   1 
ATOM 3874 C CB  . CYS C 2 49  ? 133.123 175.546 175.521 1.00 87.67  ? 55  CYS E CB  1 
ATOM 3875 S SG  . CYS C 2 49  ? 134.765 175.866 174.854 1.00 87.67  ? 55  CYS E SG  1 
ATOM 3876 N N   . SER C 2 50  ? 130.050 174.566 174.802 1.00 94.86  ? 56  SER E N   1 
ATOM 3877 C CA  . SER C 2 50  ? 128.690 174.576 175.327 1.00 94.86  ? 56  SER E CA  1 
ATOM 3878 C C   . SER C 2 50  ? 127.663 174.321 174.233 1.00 94.86  ? 56  SER E C   1 
ATOM 3879 O O   . SER C 2 50  ? 128.012 173.900 173.126 1.00 94.86  ? 56  SER E O   1 
ATOM 3880 C CB  . SER C 2 50  ? 128.402 175.911 176.011 1.00 94.86  ? 56  SER E CB  1 
ATOM 3881 O OG  . SER C 2 50  ? 128.819 176.993 175.198 1.00 94.86  ? 56  SER E OG  1 
ATOM 3882 N N   . SER C 2 51  ? 126.393 174.571 174.540 1.00 97.32  ? 57  SER E N   1 
ATOM 3883 C CA  . SER C 2 51  ? 125.320 174.411 173.563 1.00 97.32  ? 57  SER E CA  1 
ATOM 3884 C C   . SER C 2 51  ? 124.569 175.696 173.246 1.00 97.32  ? 57  SER E C   1 
ATOM 3885 O O   . SER C 2 51  ? 124.003 175.793 172.152 1.00 97.32  ? 57  SER E O   1 
ATOM 3886 C CB  . SER C 2 51  ? 124.316 173.354 174.041 1.00 97.32  ? 57  SER E CB  1 
ATOM 3887 O OG  . SER C 2 51  ? 123.969 173.559 175.399 1.00 97.32  ? 57  SER E OG  1 
ATOM 3888 N N   . TYR C 2 52  ? 124.533 176.681 174.147 1.00 98.38  ? 58  TYR E N   1 
ATOM 3889 C CA  . TYR C 2 52  ? 123.883 177.948 173.827 1.00 98.38  ? 58  TYR E CA  1 
ATOM 3890 C C   . TYR C 2 52  ? 124.566 178.625 172.647 1.00 98.38  ? 58  TYR E C   1 
ATOM 3891 O O   . TYR C 2 52  ? 123.897 179.083 171.716 1.00 98.38  ? 58  TYR E O   1 
ATOM 3892 C CB  . TYR C 2 52  ? 123.877 178.859 175.058 1.00 98.38  ? 58  TYR E CB  1 
ATOM 3893 C CG  . TYR C 2 52  ? 123.355 180.266 174.824 1.00 98.38  ? 58  TYR E CG  1 
ATOM 3894 C CD1 . TYR C 2 52  ? 124.151 181.245 174.241 1.00 98.38  ? 58  TYR E CD1 1 
ATOM 3895 C CD2 . TYR C 2 52  ? 122.060 180.611 175.185 1.00 98.38  ? 58  TYR E CD2 1 
ATOM 3896 C CE1 . TYR C 2 52  ? 123.673 182.522 174.027 1.00 98.38  ? 58  TYR E CE1 1 
ATOM 3897 C CE2 . TYR C 2 52  ? 121.574 181.886 174.975 1.00 98.38  ? 58  TYR E CE2 1 
ATOM 3898 C CZ  . TYR C 2 52  ? 122.385 182.837 174.396 1.00 98.38  ? 58  TYR E CZ  1 
ATOM 3899 O OH  . TYR C 2 52  ? 121.905 184.108 174.184 1.00 98.38  ? 58  TYR E OH  1 
ATOM 3900 N N   . PHE C 2 53  ? 125.897 178.695 172.669 1.00 92.25  ? 59  PHE E N   1 
ATOM 3901 C CA  . PHE C 2 53  ? 126.633 179.253 171.540 1.00 92.25  ? 59  PHE E CA  1 
ATOM 3902 C C   . PHE C 2 53  ? 126.466 178.382 170.302 1.00 92.25  ? 59  PHE E C   1 
ATOM 3903 O O   . PHE C 2 53  ? 126.355 178.885 169.179 1.00 92.25  ? 59  PHE E O   1 
ATOM 3904 C CB  . PHE C 2 53  ? 128.110 179.402 171.902 1.00 92.25  ? 59  PHE E CB  1 
ATOM 3905 C CG  . PHE C 2 53  ? 128.421 180.644 172.681 1.00 92.25  ? 59  PHE E CG  1 
ATOM 3906 C CD1 . PHE C 2 53  ? 127.987 181.880 172.240 1.00 92.25  ? 59  PHE E CD1 1 
ATOM 3907 C CD2 . PHE C 2 53  ? 129.150 180.574 173.856 1.00 92.25  ? 59  PHE E CD2 1 
ATOM 3908 C CE1 . PHE C 2 53  ? 128.274 183.024 172.956 1.00 92.25  ? 59  PHE E CE1 1 
ATOM 3909 C CE2 . PHE C 2 53  ? 129.439 181.714 174.576 1.00 92.25  ? 59  PHE E CE2 1 
ATOM 3910 C CZ  . PHE C 2 53  ? 129.001 182.941 174.126 1.00 92.25  ? 59  PHE E CZ  1 
ATOM 3911 N N   . HIS C 2 54  ? 126.453 177.060 170.498 1.00 90.60  ? 60  HIS E N   1 
ATOM 3912 C CA  . HIS C 2 54  ? 126.360 176.132 169.376 1.00 90.60  ? 60  HIS E CA  1 
ATOM 3913 C C   . HIS C 2 54  ? 125.055 176.307 168.612 1.00 90.60  ? 60  HIS E C   1 
ATOM 3914 O O   . HIS C 2 54  ? 125.041 176.284 167.377 1.00 90.60  ? 60  HIS E O   1 
ATOM 3915 C CB  . HIS C 2 54  ? 126.496 174.696 169.882 1.00 90.60  ? 60  HIS E CB  1 
ATOM 3916 C CG  . HIS C 2 54  ? 126.473 173.666 168.798 1.00 90.60  ? 60  HIS E CG  1 
ATOM 3917 N ND1 . HIS C 2 54  ? 126.869 173.935 167.506 1.00 90.60  ? 60  HIS E ND1 1 
ATOM 3918 C CD2 . HIS C 2 54  ? 126.101 172.364 168.815 1.00 90.60  ? 60  HIS E CD2 1 
ATOM 3919 C CE1 . HIS C 2 54  ? 126.743 172.843 166.773 1.00 90.60  ? 60  HIS E CE1 1 
ATOM 3920 N NE2 . HIS C 2 54  ? 126.277 171.876 167.543 1.00 90.60  ? 60  HIS E NE2 1 
ATOM 3921 N N   . SER C 2 55  ? 123.947 176.482 169.330 1.00 93.58  ? 61  SER E N   1 
ATOM 3922 C CA  . SER C 2 55  ? 122.654 176.658 168.682 1.00 93.58  ? 61  SER E CA  1 
ATOM 3923 C C   . SER C 2 55  ? 122.516 178.003 167.983 1.00 93.58  ? 61  SER E C   1 
ATOM 3924 O O   . SER C 2 55  ? 121.602 178.160 167.165 1.00 93.58  ? 61  SER E O   1 
ATOM 3925 C CB  . SER C 2 55  ? 121.530 176.490 169.706 1.00 93.58  ? 61  SER E CB  1 
ATOM 3926 O OG  . SER C 2 55  ? 121.750 177.306 170.843 1.00 93.58  ? 61  SER E OG  1 
ATOM 3927 N N   . ARG C 2 56  ? 123.384 178.973 168.277 1.00 91.42  ? 62  ARG E N   1 
ATOM 3928 C CA  . ARG C 2 56  ? 123.302 180.294 167.673 1.00 91.42  ? 62  ARG E CA  1 
ATOM 3929 C C   . ARG C 2 56  ? 124.413 180.596 166.678 1.00 91.42  ? 62  ARG E C   1 
ATOM 3930 O O   . ARG C 2 56  ? 124.350 181.637 166.016 1.00 91.42  ? 62  ARG E O   1 
ATOM 3931 C CB  . ARG C 2 56  ? 123.315 181.391 168.752 1.00 91.42  ? 62  ARG E CB  1 
ATOM 3932 C CG  . ARG C 2 56  ? 122.396 181.177 169.950 1.00 91.42  ? 62  ARG E CG  1 
ATOM 3933 C CD  . ARG C 2 56  ? 121.040 180.603 169.570 1.00 91.42  ? 62  ARG E CD  1 
ATOM 3934 N NE  . ARG C 2 56  ? 120.125 180.601 170.705 1.00 91.42  ? 62  ARG E NE  1 
ATOM 3935 C CZ  . ARG C 2 56  ? 118.804 180.592 170.604 1.00 91.42  ? 62  ARG E CZ  1 
ATOM 3936 N NH1 . ARG C 2 56  ? 118.201 180.588 169.427 1.00 91.42  ? 62  ARG E NH1 1 
ATOM 3937 N NH2 . ARG C 2 56  ? 118.068 180.587 171.712 1.00 91.42  ? 62  ARG E NH2 1 
ATOM 3938 N N   . ILE C 2 57  ? 125.421 179.740 166.554 1.00 87.63  ? 63  ILE E N   1 
ATOM 3939 C CA  . ILE C 2 57  ? 126.583 180.028 165.717 1.00 87.63  ? 63  ILE E CA  1 
ATOM 3940 C C   . ILE C 2 57  ? 126.477 179.361 164.349 1.00 87.63  ? 63  ILE E C   1 
ATOM 3941 O O   . ILE C 2 57  ? 126.937 179.907 163.347 1.00 87.63  ? 63  ILE E O   1 
ATOM 3942 C CB  . ILE C 2 57  ? 127.883 179.619 166.447 1.00 87.63  ? 63  ILE E CB  1 
ATOM 3943 C CG1 . ILE C 2 57  ? 129.104 180.081 165.658 1.00 87.63  ? 63  ILE E CG1 1 
ATOM 3944 C CG2 . ILE C 2 57  ? 127.952 178.114 166.640 1.00 87.63  ? 63  ILE E CG2 1 
ATOM 3945 C CD1 . ILE C 2 57  ? 129.221 181.577 165.552 1.00 87.63  ? 63  ILE E CD1 1 
ATOM 3946 N N   . VAL C 2 58  ? 125.860 178.182 164.286 1.00 92.23  ? 64  VAL E N   1 
ATOM 3947 C CA  . VAL C 2 58  ? 125.829 177.384 163.064 1.00 92.23  ? 64  VAL E CA  1 
ATOM 3948 C C   . VAL C 2 58  ? 124.834 177.960 162.067 1.00 92.23  ? 64  VAL E C   1 
ATOM 3949 O O   . VAL C 2 58  ? 123.881 178.652 162.445 1.00 92.23  ? 64  VAL E O   1 
ATOM 3950 C CB  . VAL C 2 58  ? 125.499 175.912 163.371 1.00 92.23  ? 64  VAL E CB  1 
ATOM 3951 C CG1 . VAL C 2 58  ? 126.337 175.416 164.533 1.00 92.23  ? 64  VAL E CG1 1 
ATOM 3952 C CG2 . VAL C 2 58  ? 124.014 175.743 163.668 1.00 92.23  ? 64  VAL E CG2 1 
ATOM 3953 N N   . GLY C 2 59  ? 125.069 177.701 160.783 1.00 104.81 ? 65  GLY E N   1 
ATOM 3954 C CA  . GLY C 2 59  ? 124.121 178.057 159.746 1.00 104.81 ? 65  GLY E CA  1 
ATOM 3955 C C   . GLY C 2 59  ? 124.312 179.457 159.202 1.00 104.81 ? 65  GLY E C   1 
ATOM 3956 O O   . GLY C 2 59  ? 124.247 179.679 157.989 1.00 104.81 ? 65  GLY E O   1 
ATOM 3957 N N   . GLN C 2 60  ? 124.546 180.409 160.100 1.00 103.90 ? 66  GLN E N   1 
ATOM 3958 C CA  . GLN C 2 60  ? 124.713 181.803 159.714 1.00 103.90 ? 66  GLN E CA  1 
ATOM 3959 C C   . GLN C 2 60  ? 126.009 181.994 158.934 1.00 103.90 ? 66  GLN E C   1 
ATOM 3960 O O   . GLN C 2 60  ? 127.026 181.362 159.227 1.00 103.90 ? 66  GLN E O   1 
ATOM 3961 C CB  . GLN C 2 60  ? 124.701 182.684 160.966 1.00 103.90 ? 66  GLN E CB  1 
ATOM 3962 C CG  . GLN C 2 60  ? 125.525 183.944 160.855 1.00 103.90 ? 66  GLN E CG  1 
ATOM 3963 C CD  . GLN C 2 60  ? 125.618 184.692 162.162 1.00 103.90 ? 66  GLN E CD  1 
ATOM 3964 O OE1 . GLN C 2 60  ? 126.707 185.054 162.599 1.00 103.90 ? 66  GLN E OE1 1 
ATOM 3965 N NE2 . GLN C 2 60  ? 124.477 184.923 162.799 1.00 103.90 ? 66  GLN E NE2 1 
ATOM 3966 N N   . ALA C 2 61  ? 125.961 182.875 157.935 1.00 104.62 ? 67  ALA E N   1 
ATOM 3967 C CA  . ALA C 2 61  ? 127.096 183.112 157.049 1.00 104.62 ? 67  ALA E CA  1 
ATOM 3968 C C   . ALA C 2 61  ? 128.289 183.713 157.784 1.00 104.62 ? 67  ALA E C   1 
ATOM 3969 O O   . ALA C 2 61  ? 128.133 184.316 158.852 1.00 104.62 ? 67  ALA E O   1 
ATOM 3970 C CB  . ALA C 2 61  ? 126.682 184.027 155.894 1.00 104.62 ? 67  ALA E CB  1 
ATOM 3971 N N   . ASP C 2 62  ? 129.482 183.543 157.218 1.00 96.50  ? 68  ASP E N   1 
ATOM 3972 C CA  . ASP C 2 62  ? 130.699 184.087 157.808 1.00 96.50  ? 68  ASP E CA  1 
ATOM 3973 C C   . ASP C 2 62  ? 130.704 185.609 157.729 1.00 96.50  ? 68  ASP E C   1 
ATOM 3974 O O   . ASP C 2 62  ? 130.117 186.202 156.820 1.00 96.50  ? 68  ASP E O   1 
ATOM 3975 C CB  . ASP C 2 62  ? 131.925 183.515 157.092 1.00 96.50  ? 68  ASP E CB  1 
ATOM 3976 C CG  . ASP C 2 62  ? 133.237 184.006 157.680 1.00 96.50  ? 68  ASP E CG  1 
ATOM 3977 O OD1 . ASP C 2 62  ? 133.600 185.178 157.445 1.00 96.50  ? 68  ASP E OD1 1 
ATOM 3978 O OD2 . ASP C 2 62  ? 133.912 183.212 158.372 1.00 96.50  ? 68  ASP E OD2 1 
ATOM 3979 N N   . GLY C 2 63  ? 131.365 186.240 158.688 1.00 96.85  ? 69  GLY E N   1 
ATOM 3980 C CA  . GLY C 2 63  ? 131.539 187.677 158.670 1.00 96.85  ? 69  GLY E CA  1 
ATOM 3981 C C   . GLY C 2 63  ? 131.565 188.238 160.078 1.00 96.85  ? 69  GLY E C   1 
ATOM 3982 O O   . GLY C 2 63  ? 131.707 187.505 161.052 1.00 96.85  ? 69  GLY E O   1 
ATOM 3983 N N   . GLU C 2 64  ? 131.435 189.561 160.149 1.00 107.76 ? 70  GLU E N   1 
ATOM 3984 C CA  . GLU C 2 64  ? 131.401 190.257 161.428 1.00 107.76 ? 70  GLU E CA  1 
ATOM 3985 C C   . GLU C 2 64  ? 130.208 189.789 162.252 1.00 107.76 ? 70  GLU E C   1 
ATOM 3986 O O   . GLU C 2 64  ? 129.109 189.591 161.726 1.00 107.76 ? 70  GLU E O   1 
ATOM 3987 C CB  . GLU C 2 64  ? 131.340 191.767 161.197 1.00 107.76 ? 70  GLU E CB  1 
ATOM 3988 C CG  . GLU C 2 64  ? 131.383 192.611 162.456 1.00 107.76 ? 70  GLU E CG  1 
ATOM 3989 C CD  . GLU C 2 64  ? 130.024 193.168 162.818 1.00 107.76 ? 70  GLU E CD  1 
ATOM 3990 O OE1 . GLU C 2 64  ? 129.468 193.954 162.022 1.00 107.76 ? 70  GLU E OE1 1 
ATOM 3991 O OE2 . GLU C 2 64  ? 129.510 192.818 163.898 1.00 107.76 ? 70  GLU E OE2 1 
ATOM 3992 N N   . LEU C 2 65  ? 130.429 189.605 163.554 1.00 100.74 ? 71  LEU E N   1 
ATOM 3993 C CA  . LEU C 2 65  ? 129.431 188.972 164.404 1.00 100.74 ? 71  LEU E CA  1 
ATOM 3994 C C   . LEU C 2 65  ? 129.348 189.648 165.765 1.00 100.74 ? 71  LEU E C   1 
ATOM 3995 O O   . LEU C 2 65  ? 130.370 189.962 166.381 1.00 100.74 ? 71  LEU E O   1 
ATOM 3996 C CB  . LEU C 2 65  ? 129.740 187.482 164.590 1.00 100.74 ? 71  LEU E CB  1 
ATOM 3997 C CG  . LEU C 2 65  ? 128.665 186.653 165.296 1.00 100.74 ? 71  LEU E CG  1 
ATOM 3998 C CD1 . LEU C 2 65  ? 127.277 187.052 164.830 1.00 100.74 ? 71  LEU E CD1 1 
ATOM 3999 C CD2 . LEU C 2 65  ? 128.900 185.167 165.081 1.00 100.74 ? 71  LEU E CD2 1 
ATOM 4000 N N   . ASN C 2 66  ? 128.115 189.866 166.217 1.00 104.73 ? 72  ASN E N   1 
ATOM 4001 C CA  . ASN C 2 66  ? 127.795 190.130 167.612 1.00 104.73 ? 72  ASN E CA  1 
ATOM 4002 C C   . ASN C 2 66  ? 126.825 189.054 168.070 1.00 104.73 ? 72  ASN E C   1 
ATOM 4003 O O   . ASN C 2 66  ? 125.788 188.842 167.434 1.00 104.73 ? 72  ASN E O   1 
ATOM 4004 C CB  . ASN C 2 66  ? 127.172 191.516 167.812 1.00 104.73 ? 72  ASN E CB  1 
ATOM 4005 C CG  . ASN C 2 66  ? 127.769 192.565 166.900 1.00 104.73 ? 72  ASN E CG  1 
ATOM 4006 O OD1 . ASN C 2 66  ? 128.932 192.478 166.513 1.00 104.73 ? 72  ASN E OD1 1 
ATOM 4007 N ND2 . ASN C 2 66  ? 126.969 193.563 166.544 1.00 104.73 ? 72  ASN E ND2 1 
ATOM 4008 N N   . ILE C 2 67  ? 127.163 188.371 169.159 1.00 106.00 ? 73  ILE E N   1 
ATOM 4009 C CA  . ILE C 2 67  ? 126.338 187.286 169.679 1.00 106.00 ? 73  ILE E CA  1 
ATOM 4010 C C   . ILE C 2 67  ? 125.970 187.685 171.107 1.00 106.00 ? 73  ILE E C   1 
ATOM 4011 O O   . ILE C 2 67  ? 125.980 186.867 172.034 1.00 106.00 ? 73  ILE E O   1 
ATOM 4012 C CB  . ILE C 2 67  ? 127.068 185.929 169.570 1.00 106.00 ? 73  ILE E CB  1 
ATOM 4013 C CG1 . ILE C 2 67  ? 126.229 184.770 170.126 1.00 106.00 ? 73  ILE E CG1 1 
ATOM 4014 C CG2 . ILE C 2 67  ? 128.427 185.997 170.243 1.00 106.00 ? 73  ILE E CG2 1 
ATOM 4015 C CD1 . ILE C 2 67  ? 124.851 184.667 169.510 1.00 106.00 ? 73  ILE E CD1 1 
ATOM 4016 N N   . THR C 2 68  ? 125.689 188.977 171.287 1.00 101.81 ? 74  THR E N   1 
ATOM 4017 C CA  . THR C 2 68  ? 125.433 189.608 172.579 1.00 101.81 ? 74  THR E CA  1 
ATOM 4018 C C   . THR C 2 68  ? 124.592 188.758 173.526 1.00 101.81 ? 74  THR E C   1 
ATOM 4019 O O   . THR C 2 68  ? 123.486 188.335 173.179 1.00 101.81 ? 74  THR E O   1 
ATOM 4020 C CB  . THR C 2 68  ? 124.731 190.953 172.363 1.00 101.81 ? 74  THR E CB  1 
ATOM 4021 O OG1 . THR C 2 68  ? 125.672 191.915 171.878 1.00 101.81 ? 74  THR E OG1 1 
ATOM 4022 C CG2 . THR C 2 68  ? 124.128 191.460 173.664 1.00 101.81 ? 74  THR E CG2 1 
ATOM 4023 N N   . LEU C 2 69  ? 125.116 188.502 174.719 1.00 102.18 ? 75  LEU E N   1 
ATOM 4024 C CA  . LEU C 2 69  ? 124.332 187.874 175.777 1.00 102.18 ? 75  LEU E CA  1 
ATOM 4025 C C   . LEU C 2 69  ? 123.500 188.959 176.446 1.00 102.18 ? 75  LEU E C   1 
ATOM 4026 O O   . LEU C 2 69  ? 124.064 189.821 177.131 1.00 102.18 ? 75  LEU E O   1 
ATOM 4027 C CB  . LEU C 2 69  ? 125.247 187.188 176.786 1.00 102.18 ? 75  LEU E CB  1 
ATOM 4028 C CG  . LEU C 2 69  ? 125.649 185.729 176.536 1.00 102.18 ? 75  LEU E CG  1 
ATOM 4029 C CD1 . LEU C 2 69  ? 126.005 185.473 175.080 1.00 102.18 ? 75  LEU E CD1 1 
ATOM 4030 C CD2 . LEU C 2 69  ? 126.809 185.336 177.436 1.00 102.18 ? 75  LEU E CD2 1 
ATOM 4031 N N   . PRO C 2 70  ? 122.172 188.965 176.277 1.00 108.15 ? 76  PRO E N   1 
ATOM 4032 C CA  . PRO C 2 70  ? 121.411 190.209 176.478 1.00 108.15 ? 76  PRO E CA  1 
ATOM 4033 C C   . PRO C 2 70  ? 121.495 190.835 177.865 1.00 108.15 ? 76  PRO E C   1 
ATOM 4034 O O   . PRO C 2 70  ? 122.021 191.945 177.994 1.00 108.15 ? 76  PRO E O   1 
ATOM 4035 C CB  . PRO C 2 70  ? 119.969 189.786 176.159 1.00 108.15 ? 76  PRO E CB  1 
ATOM 4036 C CG  . PRO C 2 70  ? 119.957 188.296 176.273 1.00 108.15 ? 76  PRO E CG  1 
ATOM 4037 C CD  . PRO C 2 70  ? 121.315 187.847 175.852 1.00 108.15 ? 76  PRO E CD  1 
ATOM 4038 N N   . GLU C 2 71  ? 120.995 190.166 178.905 1.00 107.06 ? 77  GLU E N   1 
ATOM 4039 C CA  . GLU C 2 71  ? 121.067 190.768 180.233 1.00 107.06 ? 77  GLU E CA  1 
ATOM 4040 C C   . GLU C 2 71  ? 121.363 189.767 181.343 1.00 107.06 ? 77  GLU E C   1 
ATOM 4041 O O   . GLU C 2 71  ? 121.885 190.142 182.398 1.00 107.06 ? 77  GLU E O   1 
ATOM 4042 C CB  . GLU C 2 71  ? 119.763 191.515 180.539 1.00 107.06 ? 77  GLU E CB  1 
ATOM 4043 C CG  . GLU C 2 71  ? 118.674 190.704 181.249 1.00 107.06 ? 77  GLU E CG  1 
ATOM 4044 C CD  . GLU C 2 71  ? 118.119 189.545 180.428 1.00 107.06 ? 77  GLU E CD  1 
ATOM 4045 O OE1 . GLU C 2 71  ? 118.673 189.214 179.359 1.00 107.06 ? 77  GLU E OE1 1 
ATOM 4046 O OE2 . GLU C 2 71  ? 117.110 188.953 180.866 1.00 107.06 ? 77  GLU E OE2 1 
ATOM 4047 N N   . GLU C 2 72  ? 121.033 188.497 181.118 1.00 110.28 ? 78  GLU E N   1 
ATOM 4048 C CA  . GLU C 2 72  ? 120.957 187.523 182.201 1.00 110.28 ? 78  GLU E CA  1 
ATOM 4049 C C   . GLU C 2 72  ? 122.321 187.233 182.816 1.00 110.28 ? 78  GLU E C   1 
ATOM 4050 O O   . GLU C 2 72  ? 122.439 187.110 184.039 1.00 110.28 ? 78  GLU E O   1 
ATOM 4051 C CB  . GLU C 2 72  ? 120.300 186.228 181.707 1.00 110.28 ? 78  GLU E CB  1 
ATOM 4052 C CG  . GLU C 2 72  ? 121.019 185.500 180.574 1.00 110.28 ? 78  GLU E CG  1 
ATOM 4053 C CD  . GLU C 2 72  ? 120.851 186.159 179.212 1.00 110.28 ? 78  GLU E CD  1 
ATOM 4054 O OE1 . GLU C 2 72  ? 120.678 185.423 178.218 1.00 110.28 ? 78  GLU E OE1 1 
ATOM 4055 O OE2 . GLU C 2 72  ? 120.909 187.404 179.125 1.00 110.28 ? 78  GLU E OE2 1 
ATOM 4056 N N   . VAL C 2 73  ? 123.356 187.118 181.983 1.00 112.21 ? 79  VAL E N   1 
ATOM 4057 C CA  . VAL C 2 73  ? 124.685 186.842 182.504 1.00 112.21 ? 79  VAL E CA  1 
ATOM 4058 C C   . VAL C 2 73  ? 125.298 188.122 183.046 1.00 112.21 ? 79  VAL E C   1 
ATOM 4059 O O   . VAL C 2 73  ? 124.929 189.232 182.645 1.00 112.21 ? 79  VAL E O   1 
ATOM 4060 C CB  . VAL C 2 73  ? 125.572 186.212 181.415 1.00 112.21 ? 79  VAL E CB  1 
ATOM 4061 C CG1 . VAL C 2 73  ? 124.847 185.055 180.745 1.00 112.21 ? 79  VAL E CG1 1 
ATOM 4062 C CG2 . VAL C 2 73  ? 125.985 187.260 180.394 1.00 112.21 ? 79  VAL E CG2 1 
ATOM 4063 N N   . THR C 2 74  ? 126.229 187.967 183.980 1.00 113.01 ? 80  THR E N   1 
ATOM 4064 C CA  . THR C 2 74  ? 127.022 189.071 184.487 1.00 113.01 ? 80  THR E CA  1 
ATOM 4065 C C   . THR C 2 74  ? 128.356 189.113 183.746 1.00 113.01 ? 80  THR E C   1 
ATOM 4066 O O   . THR C 2 74  ? 128.582 188.381 182.782 1.00 113.01 ? 80  THR E O   1 
ATOM 4067 C CB  . THR C 2 74  ? 127.230 188.935 185.996 1.00 113.01 ? 80  THR E CB  1 
ATOM 4068 O OG1 . THR C 2 74  ? 128.241 187.952 186.253 1.00 113.01 ? 80  THR E OG1 1 
ATOM 4069 C CG2 . THR C 2 74  ? 125.936 188.510 186.673 1.00 113.01 ? 80  THR E CG2 1 
ATOM 4070 N N   . VAL C 2 75  ? 129.246 189.992 184.195 1.00 104.76 ? 81  VAL E N   1 
ATOM 4071 C CA  . VAL C 2 75  ? 130.616 190.029 183.702 1.00 104.76 ? 81  VAL E CA  1 
ATOM 4072 C C   . VAL C 2 75  ? 131.572 189.346 184.670 1.00 104.76 ? 81  VAL E C   1 
ATOM 4073 O O   . VAL C 2 75  ? 132.499 188.654 184.247 1.00 104.76 ? 81  VAL E O   1 
ATOM 4074 C CB  . VAL C 2 75  ? 131.052 191.483 183.422 1.00 104.76 ? 81  VAL E CB  1 
ATOM 4075 C CG1 . VAL C 2 75  ? 130.501 191.950 182.088 1.00 104.76 ? 81  VAL E CG1 1 
ATOM 4076 C CG2 . VAL C 2 75  ? 130.592 192.401 184.542 1.00 104.76 ? 81  VAL E CG2 1 
ATOM 4077 N N   . LYS C 2 76  ? 131.353 189.538 185.973 1.00 108.84 ? 82  LYS E N   1 
ATOM 4078 C CA  . LYS C 2 76  ? 132.138 188.828 186.975 1.00 108.84 ? 82  LYS E CA  1 
ATOM 4079 C C   . LYS C 2 76  ? 131.958 187.323 186.837 1.00 108.84 ? 82  LYS E C   1 
ATOM 4080 O O   . LYS C 2 76  ? 132.863 186.546 187.164 1.00 108.84 ? 82  LYS E O   1 
ATOM 4081 C CB  . LYS C 2 76  ? 131.736 189.295 188.375 1.00 108.84 ? 82  LYS E CB  1 
ATOM 4082 C CG  . LYS C 2 76  ? 132.331 190.639 188.777 1.00 108.84 ? 82  LYS E CG  1 
ATOM 4083 C CD  . LYS C 2 76  ? 132.393 190.824 190.292 1.00 108.84 ? 82  LYS E CD  1 
ATOM 4084 C CE  . LYS C 2 76  ? 131.231 190.153 191.013 1.00 108.84 ? 82  LYS E CE  1 
ATOM 4085 N NZ  . LYS C 2 76  ? 129.904 190.678 190.580 1.00 108.84 ? 82  LYS E NZ  1 
ATOM 4086 N N   . GLY C 2 77  ? 130.793 186.895 186.361 1.00 108.27 ? 83  GLY E N   1 
ATOM 4087 C CA  . GLY C 2 77  ? 130.541 185.491 186.115 1.00 108.27 ? 83  GLY E CA  1 
ATOM 4088 C C   . GLY C 2 77  ? 130.831 185.074 184.689 1.00 108.27 ? 83  GLY E C   1 
ATOM 4089 O O   . GLY C 2 77  ? 130.724 183.892 184.351 1.00 108.27 ? 83  GLY E O   1 
ATOM 4090 N N   . PHE C 2 78  ? 131.199 186.033 183.839 1.00 98.64  ? 84  PHE E N   1 
ATOM 4091 C CA  . PHE C 2 78  ? 131.510 185.720 182.449 1.00 98.64  ? 84  PHE E CA  1 
ATOM 4092 C C   . PHE C 2 78  ? 133.005 185.594 182.204 1.00 98.64  ? 84  PHE E C   1 
ATOM 4093 O O   . PHE C 2 78  ? 133.435 184.705 181.462 1.00 98.64  ? 84  PHE E O   1 
ATOM 4094 C CB  . PHE C 2 78  ? 130.935 186.787 181.517 1.00 98.64  ? 84  PHE E CB  1 
ATOM 4095 C CG  . PHE C 2 78  ? 131.043 186.437 180.059 1.00 98.64  ? 84  PHE E CG  1 
ATOM 4096 C CD1 . PHE C 2 78  ? 130.921 185.124 179.637 1.00 98.64  ? 84  PHE E CD1 1 
ATOM 4097 C CD2 . PHE C 2 78  ? 131.280 187.419 179.113 1.00 98.64  ? 84  PHE E CD2 1 
ATOM 4098 C CE1 . PHE C 2 78  ? 131.022 184.798 178.301 1.00 98.64  ? 84  PHE E CE1 1 
ATOM 4099 C CE2 . PHE C 2 78  ? 131.384 187.098 177.774 1.00 98.64  ? 84  PHE E CE2 1 
ATOM 4100 C CZ  . PHE C 2 78  ? 131.255 185.786 177.368 1.00 98.64  ? 84  PHE E CZ  1 
ATOM 4101 N N   . GLU C 2 79  ? 133.804 186.474 182.804 1.00 92.53  ? 85  GLU E N   1 
ATOM 4102 C CA  . GLU C 2 79  ? 135.251 186.435 182.600 1.00 92.53  ? 85  GLU E CA  1 
ATOM 4103 C C   . GLU C 2 79  ? 135.874 185.080 182.919 1.00 92.53  ? 85  GLU E C   1 
ATOM 4104 O O   . GLU C 2 79  ? 136.689 184.602 182.113 1.00 92.53  ? 85  GLU E O   1 
ATOM 4105 C CB  . GLU C 2 79  ? 135.913 187.553 183.418 1.00 92.53  ? 85  GLU E CB  1 
ATOM 4106 C CG  . GLU C 2 79  ? 137.423 187.660 183.237 1.00 92.53  ? 85  GLU E CG  1 
ATOM 4107 C CD  . GLU C 2 79  ? 137.849 187.869 181.794 1.00 92.53  ? 85  GLU E CD  1 
ATOM 4108 O OE1 . GLU C 2 79  ? 139.019 187.572 181.476 1.00 92.53  ? 85  GLU E OE1 1 
ATOM 4109 O OE2 . GLU C 2 79  ? 137.031 188.353 180.984 1.00 92.53  ? 85  GLU E OE2 1 
ATOM 4110 N N   . PRO C 2 80  ? 135.561 184.416 184.039 1.00 89.78  ? 86  PRO E N   1 
ATOM 4111 C CA  . PRO C 2 80  ? 136.140 183.083 184.269 1.00 89.78  ? 86  PRO E CA  1 
ATOM 4112 C C   . PRO C 2 80  ? 135.668 182.024 183.286 1.00 89.78  ? 86  PRO E C   1 
ATOM 4113 O O   . PRO C 2 80  ? 136.404 181.057 183.051 1.00 89.78  ? 86  PRO E O   1 
ATOM 4114 C CB  . PRO C 2 80  ? 135.696 182.751 185.701 1.00 89.78  ? 86  PRO E CB  1 
ATOM 4115 C CG  . PRO C 2 80  ? 135.380 184.072 186.316 1.00 89.78  ? 86  PRO E CG  1 
ATOM 4116 C CD  . PRO C 2 80  ? 134.777 184.858 185.204 1.00 89.78  ? 86  PRO E CD  1 
ATOM 4117 N N   . LEU C 2 81  ? 134.476 182.167 182.702 1.00 87.78  ? 87  LEU E N   1 
ATOM 4118 C CA  . LEU C 2 81  ? 133.947 181.131 181.821 1.00 87.78  ? 87  LEU E CA  1 
ATOM 4119 C C   . LEU C 2 81  ? 134.761 180.946 180.549 1.00 87.78  ? 87  LEU E C   1 
ATOM 4120 O O   . LEU C 2 81  ? 135.128 179.810 180.230 1.00 87.78  ? 87  LEU E O   1 
ATOM 4121 C CB  . LEU C 2 81  ? 132.495 181.432 181.447 1.00 87.78  ? 87  LEU E CB  1 
ATOM 4122 C CG  . LEU C 2 81  ? 131.412 180.767 182.295 1.00 87.78  ? 87  LEU E CG  1 
ATOM 4123 C CD1 . LEU C 2 81  ? 131.266 179.313 181.885 1.00 87.78  ? 87  LEU E CD1 1 
ATOM 4124 C CD2 . LEU C 2 81  ? 131.724 180.872 183.772 1.00 87.78  ? 87  LEU E CD2 1 
ATOM 4125 N N   . ILE C 2 82  ? 135.055 182.022 179.814 1.00 78.84  ? 88  ILE E N   1 
ATOM 4126 C CA  . ILE C 2 82  ? 135.872 181.890 178.611 1.00 78.84  ? 88  ILE E CA  1 
ATOM 4127 C C   . ILE C 2 82  ? 137.314 181.542 178.946 1.00 78.84  ? 88  ILE E C   1 
ATOM 4128 O O   . ILE C 2 82  ? 137.982 180.868 178.144 1.00 78.84  ? 88  ILE E O   1 
ATOM 4129 C CB  . ILE C 2 82  ? 135.786 183.166 177.749 1.00 78.84  ? 88  ILE E CB  1 
ATOM 4130 C CG1 . ILE C 2 82  ? 136.783 184.224 178.216 1.00 78.84  ? 88  ILE E CG1 1 
ATOM 4131 C CG2 . ILE C 2 82  ? 134.377 183.724 177.775 1.00 78.84  ? 88  ILE E CG2 1 
ATOM 4132 C CD1 . ILE C 2 82  ? 136.937 185.374 177.249 1.00 78.84  ? 88  ILE E CD1 1 
ATOM 4133 N N   . GLN C 2 83  ? 137.809 181.953 180.115 1.00 78.68  ? 89  GLN E N   1 
ATOM 4134 C CA  . GLN C 2 83  ? 139.116 181.499 180.568 1.00 78.68  ? 89  GLN E CA  1 
ATOM 4135 C C   . GLN C 2 83  ? 139.146 179.989 180.744 1.00 78.68  ? 89  GLN E C   1 
ATOM 4136 O O   . GLN C 2 83  ? 140.103 179.337 180.313 1.00 78.68  ? 89  GLN E O   1 
ATOM 4137 C CB  . GLN C 2 83  ? 139.484 182.190 181.880 1.00 78.68  ? 89  GLN E CB  1 
ATOM 4138 C CG  . GLN C 2 83  ? 139.803 183.665 181.733 1.00 78.68  ? 89  GLN E CG  1 
ATOM 4139 C CD  . GLN C 2 83  ? 141.277 183.957 181.897 1.00 78.68  ? 89  GLN E CD  1 
ATOM 4140 O OE1 . GLN C 2 83  ? 142.125 183.126 181.575 1.00 78.68  ? 89  GLN E OE1 1 
ATOM 4141 N NE2 . GLN C 2 83  ? 141.592 185.144 182.401 1.00 78.68  ? 89  GLN E NE2 1 
ATOM 4142 N N   . PHE C 2 84  ? 138.107 179.421 181.357 1.00 77.08  ? 90  PHE E N   1 
ATOM 4143 C CA  . PHE C 2 84  ? 138.006 177.970 181.441 1.00 77.08  ? 90  PHE E CA  1 
ATOM 4144 C C   . PHE C 2 84  ? 137.851 177.341 180.066 1.00 77.08  ? 90  PHE E C   1 
ATOM 4145 O O   . PHE C 2 84  ? 138.372 176.247 179.823 1.00 77.08  ? 90  PHE E O   1 
ATOM 4146 C CB  . PHE C 2 84  ? 136.834 177.565 182.332 1.00 77.08  ? 90  PHE E CB  1 
ATOM 4147 C CG  . PHE C 2 84  ? 136.753 176.089 182.583 1.00 77.08  ? 90  PHE E CG  1 
ATOM 4148 C CD1 . PHE C 2 84  ? 137.743 175.439 183.297 1.00 77.08  ? 90  PHE E CD1 1 
ATOM 4149 C CD2 . PHE C 2 84  ? 135.692 175.349 182.093 1.00 77.08  ? 90  PHE E CD2 1 
ATOM 4150 C CE1 . PHE C 2 84  ? 137.673 174.080 183.524 1.00 77.08  ? 90  PHE E CE1 1 
ATOM 4151 C CE2 . PHE C 2 84  ? 135.617 173.990 182.317 1.00 77.08  ? 90  PHE E CE2 1 
ATOM 4152 C CZ  . PHE C 2 84  ? 136.608 173.355 183.034 1.00 77.08  ? 90  PHE E CZ  1 
ATOM 4153 N N   . ALA C 2 85  ? 137.135 178.007 179.162 1.00 69.52  ? 91  ALA E N   1 
ATOM 4154 C CA  . ALA C 2 85  ? 136.930 177.452 177.830 1.00 69.52  ? 91  ALA E CA  1 
ATOM 4155 C C   . ALA C 2 85  ? 138.243 177.343 177.066 1.00 69.52  ? 91  ALA E C   1 
ATOM 4156 O O   . ALA C 2 85  ? 138.469 176.362 176.349 1.00 69.52  ? 91  ALA E O   1 
ATOM 4157 C CB  . ALA C 2 85  ? 135.929 178.307 177.058 1.00 69.52  ? 91  ALA E CB  1 
ATOM 4158 N N   . TYR C 2 86  ? 139.117 178.336 177.205 1.00 69.37  ? 92  TYR E N   1 
ATOM 4159 C CA  . TYR C 2 86  ? 140.331 178.406 176.403 1.00 69.37  ? 92  TYR E CA  1 
ATOM 4160 C C   . TYR C 2 86  ? 141.567 177.852 177.105 1.00 69.37  ? 92  TYR E C   1 
ATOM 4161 O O   . TYR C 2 86  ? 142.577 177.607 176.438 1.00 69.37  ? 92  TYR E O   1 
ATOM 4162 C CB  . TYR C 2 86  ? 140.594 179.849 175.973 1.00 69.37  ? 92  TYR E CB  1 
ATOM 4163 C CG  . TYR C 2 86  ? 139.784 180.283 174.777 1.00 69.37  ? 92  TYR E CG  1 
ATOM 4164 C CD1 . TYR C 2 86  ? 138.506 180.794 174.930 1.00 69.37  ? 92  TYR E CD1 1 
ATOM 4165 C CD2 . TYR C 2 86  ? 140.298 180.179 173.495 1.00 69.37  ? 92  TYR E CD2 1 
ATOM 4166 C CE1 . TYR C 2 86  ? 137.764 181.192 173.840 1.00 69.37  ? 92  TYR E CE1 1 
ATOM 4167 C CE2 . TYR C 2 86  ? 139.564 180.574 172.400 1.00 69.37  ? 92  TYR E CE2 1 
ATOM 4168 C CZ  . TYR C 2 86  ? 138.298 181.078 172.577 1.00 69.37  ? 92  TYR E CZ  1 
ATOM 4169 O OH  . TYR C 2 86  ? 137.563 181.473 171.484 1.00 69.37  ? 92  TYR E OH  1 
ATOM 4170 N N   . THR C 2 87  ? 141.526 177.650 178.422 1.00 76.14  ? 93  THR E N   1 
ATOM 4171 C CA  . THR C 2 87  ? 142.743 177.267 179.129 1.00 76.14  ? 93  THR E CA  1 
ATOM 4172 C C   . THR C 2 87  ? 142.489 176.079 180.051 1.00 76.14  ? 93  THR E C   1 
ATOM 4173 O O   . THR C 2 87  ? 143.423 175.363 180.427 1.00 76.14  ? 93  THR E O   1 
ATOM 4174 C CB  . THR C 2 87  ? 143.288 178.472 179.905 1.00 76.14  ? 93  THR E CB  1 
ATOM 4175 O OG1 . THR C 2 87  ? 143.661 179.499 178.979 1.00 76.14  ? 93  THR E OG1 1 
ATOM 4176 C CG2 . THR C 2 87  ? 144.525 178.098 180.703 1.00 76.14  ? 93  THR E CG2 1 
ATOM 4177 N N   . ALA C 2 88  ? 141.219 175.859 180.399 1.00 77.57  ? 94  ALA E N   1 
ATOM 4178 C CA  . ALA C 2 88  ? 140.776 174.757 181.251 1.00 77.57  ? 94  ALA E CA  1 
ATOM 4179 C C   . ALA C 2 88  ? 141.204 174.945 182.700 1.00 77.57  ? 94  ALA E C   1 
ATOM 4180 O O   . ALA C 2 88  ? 141.553 173.975 183.379 1.00 77.57  ? 94  ALA E O   1 
ATOM 4181 C CB  . ALA C 2 88  ? 141.275 173.409 180.722 1.00 77.57  ? 94  ALA E CB  1 
ATOM 4182 N N   . LYS C 2 89  ? 141.179 176.185 183.183 1.00 85.86  ? 95  LYS E N   1 
ATOM 4183 C CA  . LYS C 2 89  ? 141.323 176.450 184.608 1.00 85.86  ? 95  LYS E CA  1 
ATOM 4184 C C   . LYS C 2 89  ? 140.257 177.457 185.006 1.00 85.86  ? 95  LYS E C   1 
ATOM 4185 O O   . LYS C 2 89  ? 139.802 178.241 184.168 1.00 85.86  ? 95  LYS E O   1 
ATOM 4186 C CB  . LYS C 2 89  ? 142.716 176.985 184.961 1.00 85.86  ? 95  LYS E CB  1 
ATOM 4187 C CG  . LYS C 2 89  ? 142.879 178.487 184.786 1.00 85.86  ? 95  LYS E CG  1 
ATOM 4188 C CD  . LYS C 2 89  ? 144.205 178.844 184.144 1.00 85.86  ? 95  LYS E CD  1 
ATOM 4189 C CE  . LYS C 2 89  ? 144.258 180.320 183.781 1.00 85.86  ? 95  LYS E CE  1 
ATOM 4190 N NZ  . LYS C 2 89  ? 143.484 180.631 182.548 1.00 85.86  ? 95  LYS E NZ  1 
ATOM 4191 N N   . LEU C 2 90  ? 139.853 177.425 186.269 1.00 97.80  ? 96  LEU E N   1 
ATOM 4192 C CA  . LEU C 2 90  ? 138.837 178.338 186.763 1.00 97.80  ? 96  LEU E CA  1 
ATOM 4193 C C   . LEU C 2 90  ? 139.407 179.223 187.867 1.00 97.80  ? 96  LEU E C   1 
ATOM 4194 O O   . LEU C 2 90  ? 140.404 178.898 188.513 1.00 97.80  ? 96  LEU E O   1 
ATOM 4195 C CB  . LEU C 2 90  ? 137.626 177.560 187.275 1.00 97.80  ? 96  LEU E CB  1 
ATOM 4196 C CG  . LEU C 2 90  ? 136.277 177.807 186.600 1.00 97.80  ? 96  LEU E CG  1 
ATOM 4197 C CD1 . LEU C 2 90  ? 135.163 177.126 187.374 1.00 97.80  ? 96  LEU E CD1 1 
ATOM 4198 C CD2 . LEU C 2 90  ? 136.008 179.290 186.475 1.00 97.80  ? 96  LEU E CD2 1 
ATOM 4199 N N   . ILE C 2 91  ? 138.756 180.363 188.079 1.00 106.00 ? 97  ILE E N   1 
ATOM 4200 C CA  . ILE C 2 91  ? 139.120 181.253 189.173 1.00 106.00 ? 97  ILE E CA  1 
ATOM 4201 C C   . ILE C 2 91  ? 137.862 181.538 189.980 1.00 106.00 ? 97  ILE E C   1 
ATOM 4202 O O   . ILE C 2 91  ? 136.999 182.317 189.560 1.00 106.00 ? 97  ILE E O   1 
ATOM 4203 C CB  . ILE C 2 91  ? 139.773 182.549 188.657 1.00 106.00 ? 97  ILE E CB  1 
ATOM 4204 C CG1 . ILE C 2 91  ? 141.196 182.264 188.167 1.00 106.00 ? 97  ILE E CG1 1 
ATOM 4205 C CG2 . ILE C 2 91  ? 139.790 183.617 189.746 1.00 106.00 ? 97  ILE E CG2 1 
ATOM 4206 C CD1 . ILE C 2 91  ? 142.272 182.460 189.218 1.00 106.00 ? 97  ILE E CD1 1 
ATOM 4207 N N   . LEU C 2 92  ? 137.737 180.887 191.129 1.00 117.91 ? 98  LEU E N   1 
ATOM 4208 C CA  . LEU C 2 92  ? 136.562 181.036 191.972 1.00 117.91 ? 98  LEU E CA  1 
ATOM 4209 C C   . LEU C 2 92  ? 136.941 181.639 193.317 1.00 117.91 ? 98  LEU E C   1 
ATOM 4210 O O   . LEU C 2 92  ? 137.970 181.300 193.907 1.00 117.91 ? 98  LEU E O   1 
ATOM 4211 C CB  . LEU C 2 92  ? 135.871 179.688 192.183 1.00 117.91 ? 98  LEU E CB  1 
ATOM 4212 C CG  . LEU C 2 92  ? 135.189 179.077 190.959 1.00 117.91 ? 98  LEU E CG  1 
ATOM 4213 C CD1 . LEU C 2 92  ? 134.697 177.674 191.270 1.00 117.91 ? 98  LEU E CD1 1 
ATOM 4214 C CD2 . LEU C 2 92  ? 134.043 179.958 190.488 1.00 117.91 ? 98  LEU E CD2 1 
ATOM 4215 N N   . SER C 2 93  ? 136.091 182.542 193.797 1.00 122.39 ? 99  SER E N   1 
ATOM 4216 C CA  . SER C 2 93  ? 136.262 183.169 195.097 1.00 122.39 ? 99  SER E CA  1 
ATOM 4217 C C   . SER C 2 93  ? 134.893 183.288 195.752 1.00 122.39 ? 99  SER E C   1 
ATOM 4218 O O   . SER C 2 93  ? 133.856 183.166 195.093 1.00 122.39 ? 99  SER E O   1 
ATOM 4219 C CB  . SER C 2 93  ? 136.947 184.534 194.969 1.00 122.39 ? 99  SER E CB  1 
ATOM 4220 O OG  . SER C 2 93  ? 135.996 185.560 194.750 1.00 122.39 ? 99  SER E OG  1 
ATOM 4221 N N   . LYS C 2 94  ? 134.889 183.552 197.057 1.00 123.04 ? 100 LYS E N   1 
ATOM 4222 C CA  . LYS C 2 94  ? 133.659 183.599 197.849 1.00 123.04 ? 100 LYS E CA  1 
ATOM 4223 C C   . LYS C 2 94  ? 132.724 184.715 197.401 1.00 123.04 ? 100 LYS E C   1 
ATOM 4224 O O   . LYS C 2 94  ? 131.576 184.797 197.845 1.00 123.04 ? 100 LYS E O   1 
ATOM 4225 C CB  . LYS C 2 94  ? 134.015 183.746 199.325 1.00 123.04 ? 100 LYS E CB  1 
ATOM 4226 C CG  . LYS C 2 94  ? 132.887 183.411 200.289 1.00 123.04 ? 100 LYS E CG  1 
ATOM 4227 C CD  . LYS C 2 94  ? 133.338 183.551 201.732 1.00 123.04 ? 100 LYS E CD  1 
ATOM 4228 C CE  . LYS C 2 94  ? 132.176 183.371 202.694 1.00 123.04 ? 100 LYS E CE  1 
ATOM 4229 N NZ  . LYS C 2 94  ? 132.592 183.577 204.109 1.00 123.04 ? 100 LYS E NZ  1 
ATOM 4230 N N   . GLU C 2 95  ? 133.185 185.580 196.500 1.00 119.86 ? 101 GLU E N   1 
ATOM 4231 C CA  . GLU C 2 95  ? 132.352 186.645 195.964 1.00 119.86 ? 101 GLU E CA  1 
ATOM 4232 C C   . GLU C 2 95  ? 132.161 186.441 194.468 1.00 119.86 ? 101 GLU E C   1 
ATOM 4233 O O   . GLU C 2 95  ? 131.845 187.386 193.738 1.00 119.86 ? 101 GLU E O   1 
ATOM 4234 C CB  . GLU C 2 95  ? 132.975 188.016 196.242 1.00 119.86 ? 101 GLU E CB  1 
ATOM 4235 C CG  . GLU C 2 95  ? 134.462 188.125 195.910 1.00 119.86 ? 101 GLU E CG  1 
ATOM 4236 C CD  . GLU C 2 95  ? 135.369 187.642 197.029 1.00 119.86 ? 101 GLU E CD  1 
ATOM 4237 O OE1 . GLU C 2 95  ? 135.029 186.642 197.693 1.00 119.86 ? 101 GLU E OE1 1 
ATOM 4238 O OE2 . GLU C 2 95  ? 136.429 188.265 197.244 1.00 119.86 ? 101 GLU E OE2 1 
ATOM 4239 N N   . ASN C 2 96  ? 132.357 185.207 194.003 1.00 117.50 ? 102 ASN E N   1 
ATOM 4240 C CA  . ASN C 2 96  ? 132.312 184.914 192.577 1.00 117.50 ? 102 ASN E CA  1 
ATOM 4241 C C   . ASN C 2 96  ? 131.468 183.682 192.271 1.00 117.50 ? 102 ASN E C   1 
ATOM 4242 O O   . ASN C 2 96  ? 130.995 183.517 191.144 1.00 117.50 ? 102 ASN E O   1 
ATOM 4243 C CB  . ASN C 2 96  ? 133.730 184.720 192.037 1.00 117.50 ? 102 ASN E CB  1 
ATOM 4244 C CG  . ASN C 2 96  ? 133.964 185.460 190.738 1.00 117.50 ? 102 ASN E CG  1 
ATOM 4245 O OD1 . ASN C 2 96  ? 133.929 186.689 190.696 1.00 117.50 ? 102 ASN E OD1 1 
ATOM 4246 N ND2 . ASN C 2 96  ? 134.208 184.714 189.668 1.00 117.50 ? 102 ASN E ND2 1 
ATOM 4247 N N   . VAL C 2 97  ? 131.271 182.819 193.265 1.00 119.54 ? 103 VAL E N   1 
ATOM 4248 C CA  . VAL C 2 97  ? 130.700 181.492 193.052 1.00 119.54 ? 103 VAL E CA  1 
ATOM 4249 C C   . VAL C 2 97  ? 129.301 181.563 192.455 1.00 119.54 ? 103 VAL E C   1 
ATOM 4250 O O   . VAL C 2 97  ? 128.977 180.817 191.525 1.00 119.54 ? 103 VAL E O   1 
ATOM 4251 C CB  . VAL C 2 97  ? 130.680 180.694 194.367 1.00 119.54 ? 103 VAL E CB  1 
ATOM 4252 C CG1 . VAL C 2 97  ? 130.118 179.300 194.135 1.00 119.54 ? 103 VAL E CG1 1 
ATOM 4253 C CG2 . VAL C 2 97  ? 132.072 180.622 194.952 1.00 119.54 ? 103 VAL E CG2 1 
ATOM 4254 N N   . ASP C 2 98  ? 128.460 182.451 192.991 1.00 118.56 ? 104 ASP E N   1 
ATOM 4255 C CA  . ASP C 2 98  ? 127.051 182.457 192.608 1.00 118.56 ? 104 ASP E CA  1 
ATOM 4256 C C   . ASP C 2 98  ? 126.868 182.774 191.128 1.00 118.56 ? 104 ASP E C   1 
ATOM 4257 O O   . ASP C 2 98  ? 126.134 182.072 190.423 1.00 118.56 ? 104 ASP E O   1 
ATOM 4258 C CB  . ASP C 2 98  ? 126.279 183.458 193.467 1.00 118.56 ? 104 ASP E CB  1 
ATOM 4259 C CG  . ASP C 2 98  ? 124.946 182.914 193.936 1.00 118.56 ? 104 ASP E CG  1 
ATOM 4260 O OD1 . ASP C 2 98  ? 124.604 181.773 193.560 1.00 118.56 ? 104 ASP E OD1 1 
ATOM 4261 O OD2 . ASP C 2 98  ? 124.240 183.626 194.680 1.00 118.56 ? 104 ASP E OD2 1 
ATOM 4262 N N   . GLU C 2 99  ? 127.526 183.826 190.638 1.00 119.42 ? 105 GLU E N   1 
ATOM 4263 C CA  . GLU C 2 99  ? 127.353 184.219 189.242 1.00 119.42 ? 105 GLU E CA  1 
ATOM 4264 C C   . GLU C 2 99  ? 127.947 183.189 188.288 1.00 119.42 ? 105 GLU E C   1 
ATOM 4265 O O   . GLU C 2 99  ? 127.364 182.906 187.235 1.00 119.42 ? 105 GLU E O   1 
ATOM 4266 C CB  . GLU C 2 99  ? 127.956 185.605 189.005 1.00 119.42 ? 105 GLU E CB  1 
ATOM 4267 C CG  . GLU C 2 99  ? 129.384 185.778 189.496 1.00 119.42 ? 105 GLU E CG  1 
ATOM 4268 C CD  . GLU C 2 99  ? 129.454 186.141 190.970 1.00 119.42 ? 105 GLU E CD  1 
ATOM 4269 O OE1 . GLU C 2 99  ? 128.963 185.353 191.806 1.00 119.42 ? 105 GLU E OE1 1 
ATOM 4270 O OE2 . GLU C 2 99  ? 130.002 187.215 191.293 1.00 119.42 ? 105 GLU E OE2 1 
ATOM 4271 N N   . VAL C 2 100 ? 129.099 182.612 188.635 1.00 115.59 ? 106 VAL E N   1 
ATOM 4272 C CA  . VAL C 2 100 ? 129.683 181.571 187.793 1.00 115.59 ? 106 VAL E CA  1 
ATOM 4273 C C   . VAL C 2 100 ? 128.763 180.358 187.726 1.00 115.59 ? 106 VAL E C   1 
ATOM 4274 O O   . VAL C 2 100 ? 128.540 179.789 186.651 1.00 115.59 ? 106 VAL E O   1 
ATOM 4275 C CB  . VAL C 2 100 ? 131.087 181.190 188.293 1.00 115.59 ? 106 VAL E CB  1 
ATOM 4276 C CG1 . VAL C 2 100 ? 131.746 180.235 187.321 1.00 115.59 ? 106 VAL E CG1 1 
ATOM 4277 C CG2 . VAL C 2 100 ? 131.945 182.432 188.434 1.00 115.59 ? 106 VAL E CG2 1 
ATOM 4278 N N   . CYS C 2 101 ? 128.220 179.940 188.872 1.00 115.47 ? 107 CYS E N   1 
ATOM 4279 C CA  . CYS C 2 101 ? 127.296 178.813 188.881 1.00 115.47 ? 107 CYS E CA  1 
ATOM 4280 C C   . CYS C 2 101 ? 126.019 179.118 188.112 1.00 115.47 ? 107 CYS E C   1 
ATOM 4281 O O   . CYS C 2 101 ? 125.459 178.217 187.479 1.00 115.47 ? 107 CYS E O   1 
ATOM 4282 C CB  . CYS C 2 101 ? 126.958 178.416 190.318 1.00 115.47 ? 107 CYS E CB  1 
ATOM 4283 S SG  . CYS C 2 101 ? 125.997 176.892 190.457 1.00 115.47 ? 107 CYS E SG  1 
ATOM 4284 N N   . LYS C 2 102 ? 125.546 180.364 188.160 1.00 111.10 ? 108 LYS E N   1 
ATOM 4285 C CA  . LYS C 2 102 ? 124.398 180.753 187.349 1.00 111.10 ? 108 LYS E CA  1 
ATOM 4286 C C   . LYS C 2 102 ? 124.726 180.658 185.865 1.00 111.10 ? 108 LYS E C   1 
ATOM 4287 O O   . LYS C 2 102 ? 123.906 180.203 185.060 1.00 111.10 ? 108 LYS E O   1 
ATOM 4288 C CB  . LYS C 2 102 ? 123.958 182.170 187.718 1.00 111.10 ? 108 LYS E CB  1 
ATOM 4289 C CG  . LYS C 2 102 ? 122.573 182.543 187.222 1.00 111.10 ? 108 LYS E CG  1 
ATOM 4290 C CD  . LYS C 2 102 ? 121.513 181.654 187.848 1.00 111.10 ? 108 LYS E CD  1 
ATOM 4291 C CE  . LYS C 2 102 ? 120.975 182.258 189.135 1.00 111.10 ? 108 LYS E CE  1 
ATOM 4292 N NZ  . LYS C 2 102 ? 119.986 181.364 189.796 1.00 111.10 ? 108 LYS E NZ  1 
ATOM 4293 N N   . CYS C 2 103 ? 125.930 181.089 185.485 1.00 110.07 ? 109 CYS E N   1 
ATOM 4294 C CA  . CYS C 2 103 ? 126.354 181.034 184.092 1.00 110.07 ? 109 CYS E CA  1 
ATOM 4295 C C   . CYS C 2 103 ? 126.499 179.612 183.567 1.00 110.07 ? 109 CYS E C   1 
ATOM 4296 O O   . CYS C 2 103 ? 126.104 179.354 182.425 1.00 110.07 ? 109 CYS E O   1 
ATOM 4297 C CB  . CYS C 2 103 ? 127.676 181.783 183.919 1.00 110.07 ? 109 CYS E CB  1 
ATOM 4298 S SG  . CYS C 2 103 ? 127.494 183.560 183.651 1.00 110.07 ? 109 CYS E SG  1 
ATOM 4299 N N   . VAL C 2 104 ? 127.067 178.695 184.352 1.00 106.91 ? 110 VAL E N   1 
ATOM 4300 C CA  . VAL C 2 104 ? 127.213 177.327 183.858 1.00 106.91 ? 110 VAL E CA  1 
ATOM 4301 C C   . VAL C 2 104 ? 125.860 176.660 183.636 1.00 106.91 ? 110 VAL E C   1 
ATOM 4302 O O   . VAL C 2 104 ? 125.643 176.035 182.591 1.00 106.91 ? 110 VAL E O   1 
ATOM 4303 C CB  . VAL C 2 104 ? 128.090 176.470 184.785 1.00 106.91 ? 110 VAL E CB  1 
ATOM 4304 C CG1 . VAL C 2 104 ? 128.609 175.276 184.023 1.00 106.91 ? 110 VAL E CG1 1 
ATOM 4305 C CG2 . VAL C 2 104 ? 129.267 177.264 185.284 1.00 106.91 ? 110 VAL E CG2 1 
ATOM 4306 N N   . GLU C 2 105 ? 124.935 176.770 184.590 1.00 107.98 ? 111 GLU E N   1 
ATOM 4307 C CA  . GLU C 2 105 ? 123.634 176.134 184.430 1.00 107.98 ? 111 GLU E CA  1 
ATOM 4308 C C   . GLU C 2 105 ? 122.810 176.756 183.312 1.00 107.98 ? 111 GLU E C   1 
ATOM 4309 O O   . GLU C 2 105 ? 121.831 176.143 182.871 1.00 107.98 ? 111 GLU E O   1 
ATOM 4310 C CB  . GLU C 2 105 ? 122.842 176.193 185.737 1.00 107.98 ? 111 GLU E CB  1 
ATOM 4311 C CG  . GLU C 2 105 ? 122.067 177.482 185.936 1.00 107.98 ? 111 GLU E CG  1 
ATOM 4312 C CD  . GLU C 2 105 ? 120.981 177.348 186.984 1.00 107.98 ? 111 GLU E CD  1 
ATOM 4313 O OE1 . GLU C 2 105 ? 119.903 176.809 186.655 1.00 107.98 ? 111 GLU E OE1 1 
ATOM 4314 O OE2 . GLU C 2 105 ? 121.205 177.777 188.135 1.00 107.98 ? 111 GLU E OE2 1 
ATOM 4315 N N   . PHE C 2 106 ? 123.179 177.948 182.847 1.00 102.17 ? 112 PHE E N   1 
ATOM 4316 C CA  . PHE C 2 106 ? 122.516 178.591 181.720 1.00 102.17 ? 112 PHE E CA  1 
ATOM 4317 C C   . PHE C 2 106 ? 123.147 178.169 180.397 1.00 102.17 ? 112 PHE E C   1 
ATOM 4318 O O   . PHE C 2 106 ? 122.473 177.595 179.536 1.00 102.17 ? 112 PHE E O   1 
ATOM 4319 C CB  . PHE C 2 106 ? 122.578 180.117 181.883 1.00 102.17 ? 112 PHE E CB  1 
ATOM 4320 C CG  . PHE C 2 106 ? 122.114 180.880 180.674 1.00 102.17 ? 112 PHE E CG  1 
ATOM 4321 C CD1 . PHE C 2 106 ? 121.039 180.437 179.920 1.00 102.17 ? 112 PHE E CD1 1 
ATOM 4322 C CD2 . PHE C 2 106 ? 122.775 182.026 180.275 1.00 102.17 ? 112 PHE E CD2 1 
ATOM 4323 C CE1 . PHE C 2 106 ? 120.623 181.135 178.805 1.00 102.17 ? 112 PHE E CE1 1 
ATOM 4324 C CE2 . PHE C 2 106 ? 122.365 182.724 179.160 1.00 102.17 ? 112 PHE E CE2 1 
ATOM 4325 C CZ  . PHE C 2 106 ? 121.287 182.280 178.426 1.00 102.17 ? 112 PHE E CZ  1 
ATOM 4326 N N   . LEU C 2 107 ? 124.441 178.442 180.223 1.00 102.81 ? 113 LEU E N   1 
ATOM 4327 C CA  . LEU C 2 107 ? 125.115 178.133 178.969 1.00 102.81 ? 113 LEU E CA  1 
ATOM 4328 C C   . LEU C 2 107 ? 125.338 176.642 178.767 1.00 102.81 ? 113 LEU E C   1 
ATOM 4329 O O   . LEU C 2 107 ? 125.668 176.234 177.648 1.00 102.81 ? 113 LEU E O   1 
ATOM 4330 C CB  . LEU C 2 107 ? 126.454 178.869 178.900 1.00 102.81 ? 113 LEU E CB  1 
ATOM 4331 C CG  . LEU C 2 107 ? 126.369 180.396 178.880 1.00 102.81 ? 113 LEU E CG  1 
ATOM 4332 C CD1 . LEU C 2 107 ? 127.754 181.016 178.960 1.00 102.81 ? 113 LEU E CD1 1 
ATOM 4333 C CD2 . LEU C 2 107 ? 125.633 180.875 177.641 1.00 102.81 ? 113 LEU E CD2 1 
ATOM 4334 N N   . SER C 2 108 ? 125.163 175.828 179.809 1.00 103.40 ? 114 SER E N   1 
ATOM 4335 C CA  . SER C 2 108 ? 125.358 174.379 179.733 1.00 103.40 ? 114 SER E CA  1 
ATOM 4336 C C   . SER C 2 108 ? 126.758 174.018 179.244 1.00 103.40 ? 114 SER E C   1 
ATOM 4337 O O   . SER C 2 108 ? 126.919 173.176 178.359 1.00 103.40 ? 114 SER E O   1 
ATOM 4338 C CB  . SER C 2 108 ? 124.299 173.720 178.845 1.00 103.40 ? 114 SER E CB  1 
ATOM 4339 O OG  . SER C 2 108 ? 124.694 173.743 177.486 1.00 103.40 ? 114 SER E OG  1 
ATOM 4340 N N   . VAL C 2 109 ? 127.777 174.659 179.812 1.00 95.79  ? 115 VAL E N   1 
ATOM 4341 C CA  . VAL C 2 109 ? 129.158 174.358 179.452 1.00 95.79  ? 115 VAL E CA  1 
ATOM 4342 C C   . VAL C 2 109 ? 129.490 172.946 179.917 1.00 95.79  ? 115 VAL E C   1 
ATOM 4343 O O   . VAL C 2 109 ? 129.151 172.552 181.038 1.00 95.79  ? 115 VAL E O   1 
ATOM 4344 C CB  . VAL C 2 109 ? 130.118 175.386 180.060 1.00 95.79  ? 115 VAL E CB  1 
ATOM 4345 C CG1 . VAL C 2 109 ? 131.555 175.038 179.716 1.00 95.79  ? 115 VAL E CG1 1 
ATOM 4346 C CG2 . VAL C 2 109 ? 129.771 176.782 179.574 1.00 95.79  ? 115 VAL E CG2 1 
ATOM 4347 N N   . HIS C 2 110 ? 130.137 172.172 179.050 1.00 93.68  ? 116 HIS E N   1 
ATOM 4348 C CA  . HIS C 2 110 ? 130.483 170.802 179.393 1.00 93.68  ? 116 HIS E CA  1 
ATOM 4349 C C   . HIS C 2 110 ? 131.857 170.741 180.063 1.00 93.68  ? 116 HIS E C   1 
ATOM 4350 O O   . HIS C 2 110 ? 132.536 171.752 180.261 1.00 93.68  ? 116 HIS E O   1 
ATOM 4351 C CB  . HIS C 2 110 ? 130.456 169.913 178.151 1.00 93.68  ? 116 HIS E CB  1 
ATOM 4352 C CG  . HIS C 2 110 ? 129.306 170.188 177.235 1.00 93.68  ? 116 HIS E CG  1 
ATOM 4353 N ND1 . HIS C 2 110 ? 129.415 170.999 176.127 1.00 93.68  ? 116 HIS E ND1 1 
ATOM 4354 C CD2 . HIS C 2 110 ? 128.024 169.756 177.261 1.00 93.68  ? 116 HIS E CD2 1 
ATOM 4355 C CE1 . HIS C 2 110 ? 128.249 171.057 175.510 1.00 93.68  ? 116 HIS E CE1 1 
ATOM 4356 N NE2 . HIS C 2 110 ? 127.387 170.312 176.178 1.00 93.68  ? 116 HIS E NE2 1 
ATOM 4357 N N   . ASN C 2 111 ? 132.260 169.516 180.409 1.00 87.72  ? 117 ASN E N   1 
ATOM 4358 C CA  . ASN C 2 111 ? 133.527 169.213 181.076 1.00 87.72  ? 117 ASN E CA  1 
ATOM 4359 C C   . ASN C 2 111 ? 133.737 170.017 182.353 1.00 87.72  ? 117 ASN E C   1 
ATOM 4360 O O   . ASN C 2 111 ? 134.872 170.168 182.813 1.00 87.72  ? 117 ASN E O   1 
ATOM 4361 C CB  . ASN C 2 111 ? 134.725 169.405 180.140 1.00 87.72  ? 117 ASN E CB  1 
ATOM 4362 C CG  . ASN C 2 111 ? 134.411 169.050 178.707 1.00 87.72  ? 117 ASN E CG  1 
ATOM 4363 O OD1 . ASN C 2 111 ? 133.597 169.694 178.050 1.00 87.72  ? 117 ASN E OD1 1 
ATOM 4364 N ND2 . ASN C 2 111 ? 135.052 168.001 178.217 1.00 87.72  ? 117 ASN E ND2 1 
ATOM 4365 N N   . ILE C 2 112 ? 132.666 170.536 182.942 1.00 99.68  ? 118 ILE E N   1 
ATOM 4366 C CA  . ILE C 2 112 ? 132.722 171.211 184.232 1.00 99.68  ? 118 ILE E CA  1 
ATOM 4367 C C   . ILE C 2 112 ? 131.677 170.564 185.133 1.00 99.68  ? 118 ILE E C   1 
ATOM 4368 O O   . ILE C 2 112 ? 130.490 170.519 184.788 1.00 99.68  ? 118 ILE E O   1 
ATOM 4369 C CB  . ILE C 2 112 ? 132.505 172.727 184.111 1.00 99.68  ? 118 ILE E CB  1 
ATOM 4370 C CG1 . ILE C 2 112 ? 132.502 173.389 185.492 1.00 99.68  ? 118 ILE E CG1 1 
ATOM 4371 C CG2 . ILE C 2 112 ? 131.263 173.047 183.300 1.00 99.68  ? 118 ILE E CG2 1 
ATOM 4372 C CD1 . ILE C 2 112 ? 132.788 174.874 185.457 1.00 99.68  ? 118 ILE E CD1 1 
ATOM 4373 N N   . GLU C 2 113 ? 132.121 170.038 186.269 1.00 119.87 ? 119 GLU E N   1 
ATOM 4374 C CA  . GLU C 2 113 ? 131.237 169.341 187.185 1.00 119.87 ? 119 GLU E CA  1 
ATOM 4375 C C   . GLU C 2 113 ? 130.740 170.308 188.261 1.00 119.87 ? 119 GLU E C   1 
ATOM 4376 O O   . GLU C 2 113 ? 131.318 171.373 188.494 1.00 119.87 ? 119 GLU E O   1 
ATOM 4377 C CB  . GLU C 2 113 ? 131.967 168.132 187.784 1.00 119.87 ? 119 GLU E CB  1 
ATOM 4378 C CG  . GLU C 2 113 ? 131.254 167.386 188.907 1.00 119.87 ? 119 GLU E CG  1 
ATOM 4379 C CD  . GLU C 2 113 ? 130.290 166.336 188.391 1.00 119.87 ? 119 GLU E CD  1 
ATOM 4380 O OE1 . GLU C 2 113 ? 129.126 166.322 188.845 1.00 119.87 ? 119 GLU E OE1 1 
ATOM 4381 O OE2 . GLU C 2 113 ? 130.694 165.523 187.534 1.00 119.87 ? 119 GLU E OE2 1 
ATOM 4382 N N   . GLU C 2 114 ? 129.647 169.923 188.927 1.00 135.98 ? 120 GLU E N   1 
ATOM 4383 C CA  . GLU C 2 114 ? 129.073 170.759 189.977 1.00 135.98 ? 120 GLU E CA  1 
ATOM 4384 C C   . GLU C 2 114 ? 129.962 170.815 191.215 1.00 135.98 ? 120 GLU E C   1 
ATOM 4385 O O   . GLU C 2 114 ? 129.556 171.375 192.239 1.00 135.98 ? 120 GLU E O   1 
ATOM 4386 C CB  . GLU C 2 114 ? 127.670 170.252 190.327 1.00 135.98 ? 120 GLU E CB  1 
ATOM 4387 C CG  . GLU C 2 114 ? 127.625 169.003 191.208 1.00 135.98 ? 120 GLU E CG  1 
ATOM 4388 C CD  . GLU C 2 114 ? 127.557 169.318 192.692 1.00 135.98 ? 120 GLU E CD  1 
ATOM 4389 O OE1 . GLU C 2 114 ? 126.826 170.257 193.069 1.00 135.98 ? 120 GLU E OE1 1 
ATOM 4390 O OE2 . GLU C 2 114 ? 128.239 168.628 193.479 1.00 135.98 ? 120 GLU E OE2 1 
ATOM 4391 N N   . SER C 2 115 ? 131.179 170.271 191.133 1.00 131.27 ? 121 SER E N   1 
ATOM 4392 C CA  . SER C 2 115 ? 132.119 170.225 192.249 1.00 131.27 ? 121 SER E CA  1 
ATOM 4393 C C   . SER C 2 115 ? 132.366 171.595 192.873 1.00 131.27 ? 121 SER E C   1 
ATOM 4394 O O   . SER C 2 115 ? 132.900 171.685 193.984 1.00 131.27 ? 121 SER E O   1 
ATOM 4395 C CB  . SER C 2 115 ? 133.447 169.618 191.791 1.00 131.27 ? 121 SER E CB  1 
ATOM 4396 O OG  . SER C 2 115 ? 133.449 168.212 191.965 1.00 131.27 ? 121 SER E OG  1 
ATOM 4397 N N   . CYS C 2 116 ? 131.987 172.668 192.176 1.00 140.93 ? 122 CYS E N   1 
ATOM 4398 C CA  . CYS C 2 116 ? 132.008 174.012 192.752 1.00 140.93 ? 122 CYS E CA  1 
ATOM 4399 C C   . CYS C 2 116 ? 130.785 174.207 193.654 1.00 140.93 ? 122 CYS E C   1 
ATOM 4400 O O   . CYS C 2 116 ? 129.979 175.123 193.489 1.00 140.93 ? 122 CYS E O   1 
ATOM 4401 C CB  . CYS C 2 116 ? 132.061 175.063 191.651 1.00 140.93 ? 122 CYS E CB  1 
ATOM 4402 S SG  . CYS C 2 116 ? 131.007 174.714 190.223 1.00 140.93 ? 122 CYS E SG  1 
ATOM 4403 N N   . PHE C 2 117 ? 130.666 173.309 194.632 1.00 146.89 ? 123 PHE E N   1 
ATOM 4404 C CA  . PHE C 2 117 ? 129.487 173.206 195.481 1.00 146.89 ? 123 PHE E CA  1 
ATOM 4405 C C   . PHE C 2 117 ? 129.759 173.472 196.953 1.00 146.89 ? 123 PHE E C   1 
ATOM 4406 O O   . PHE C 2 117 ? 129.068 174.296 197.553 1.00 146.89 ? 123 PHE E O   1 
ATOM 4407 C CB  . PHE C 2 117 ? 128.862 171.811 195.336 1.00 146.89 ? 123 PHE E CB  1 
ATOM 4408 C CG  . PHE C 2 117 ? 127.733 171.543 196.289 1.00 146.89 ? 123 PHE E CG  1 
ATOM 4409 C CD1 . PHE C 2 117 ? 126.471 172.063 196.056 1.00 146.89 ? 123 PHE E CD1 1 
ATOM 4410 C CD2 . PHE C 2 117 ? 127.929 170.751 197.409 1.00 146.89 ? 123 PHE E CD2 1 
ATOM 4411 C CE1 . PHE C 2 117 ? 125.429 171.811 196.930 1.00 146.89 ? 123 PHE E CE1 1 
ATOM 4412 C CE2 . PHE C 2 117 ? 126.893 170.495 198.286 1.00 146.89 ? 123 PHE E CE2 1 
ATOM 4413 C CZ  . PHE C 2 117 ? 125.641 171.026 198.046 1.00 146.89 ? 123 PHE E CZ  1 
ATOM 4414 N N   . GLN C 2 118 ? 130.743 172.799 197.547 1.00 146.77 ? 124 GLN E N   1 
ATOM 4415 C CA  . GLN C 2 118 ? 130.991 172.924 198.977 1.00 146.77 ? 124 GLN E CA  1 
ATOM 4416 C C   . GLN C 2 118 ? 132.435 173.324 199.254 1.00 146.77 ? 124 GLN E C   1 
ATOM 4417 O O   . GLN C 2 118 ? 132.872 173.337 200.410 1.00 146.77 ? 124 GLN E O   1 
ATOM 4418 C CB  . GLN C 2 118 ? 130.651 171.611 199.691 1.00 146.77 ? 124 GLN E CB  1 
ATOM 4419 C CG  . GLN C 2 118 ? 131.715 170.515 199.587 1.00 146.77 ? 124 GLN E CG  1 
ATOM 4420 C CD  . GLN C 2 118 ? 131.925 170.000 198.171 1.00 146.77 ? 124 GLN E CD  1 
ATOM 4421 O OE1 . GLN C 2 118 ? 131.201 170.366 197.244 1.00 146.77 ? 124 GLN E OE1 1 
ATOM 4422 N NE2 . GLN C 2 118 ? 132.923 169.140 198.001 1.00 146.77 ? 124 GLN E NE2 1 
ATOM 4423 N N   . PHE C 2 119 ? 133.179 173.658 198.200 1.00 144.32 ? 125 PHE E N   1 
ATOM 4424 C CA  . PHE C 2 119 ? 134.573 174.061 198.337 1.00 144.32 ? 125 PHE E CA  1 
ATOM 4425 C C   . PHE C 2 119 ? 134.688 175.347 199.145 1.00 144.32 ? 125 PHE E C   1 
ATOM 4426 O O   . PHE C 2 119 ? 135.724 175.609 199.766 1.00 144.32 ? 125 PHE E O   1 
ATOM 4427 C CB  . PHE C 2 119 ? 135.220 174.254 196.964 1.00 144.32 ? 125 PHE E CB  1 
ATOM 4428 C CG  . PHE C 2 119 ? 134.681 175.431 196.198 1.00 144.32 ? 125 PHE E CG  1 
ATOM 4429 C CD1 . PHE C 2 119 ? 133.396 175.419 195.683 1.00 144.32 ? 125 PHE E CD1 1 
ATOM 4430 C CD2 . PHE C 2 119 ? 135.462 176.556 196.002 1.00 144.32 ? 125 PHE E CD2 1 
ATOM 4431 C CE1 . PHE C 2 119 ? 132.907 176.505 194.984 1.00 144.32 ? 125 PHE E CE1 1 
ATOM 4432 C CE2 . PHE C 2 119 ? 134.979 177.641 195.302 1.00 144.32 ? 125 PHE E CE2 1 
ATOM 4433 C CZ  . PHE C 2 119 ? 133.701 177.614 194.792 1.00 144.32 ? 125 PHE E CZ  1 
ATOM 4434 N N   . LEU C 2 120 ? 133.628 176.155 199.136 1.00 144.06 ? 126 LEU E N   1 
ATOM 4435 C CA  . LEU C 2 120 ? 133.618 177.439 199.826 1.00 144.06 ? 126 LEU E CA  1 
ATOM 4436 C C   . LEU C 2 120 ? 133.778 177.272 201.331 1.00 144.06 ? 126 LEU E C   1 
ATOM 4437 O O   . LEU C 2 120 ? 133.699 176.153 201.850 1.00 144.06 ? 126 LEU E O   1 
ATOM 4438 C CB  . LEU C 2 120 ? 132.323 178.195 199.525 1.00 144.06 ? 126 LEU E CB  1 
ATOM 4439 C CG  . LEU C 2 120 ? 132.329 179.145 198.329 1.00 144.06 ? 126 LEU E CG  1 
ATOM 4440 C CD1 . LEU C 2 120 ? 131.095 180.034 198.363 1.00 144.06 ? 126 LEU E CD1 1 
ATOM 4441 C CD2 . LEU C 2 120 ? 133.602 179.976 198.305 1.00 144.06 ? 126 LEU E CD2 1 
ATOM 4442 N N   . LYS C 2 121 ? 133.982 178.385 202.033 1.00 147.05 ? 127 LYS E N   1 
ATOM 4443 C CA  . LYS C 2 121 ? 134.151 178.399 203.486 1.00 147.05 ? 127 LYS E CA  1 
ATOM 4444 C C   . LYS C 2 121 ? 135.236 177.428 203.943 1.00 147.05 ? 127 LYS E C   1 
ATOM 4445 O O   . LYS C 2 121 ? 136.298 177.334 203.326 1.00 147.05 ? 127 LYS E O   1 
ATOM 4446 C CB  . LYS C 2 121 ? 132.826 178.078 204.192 1.00 147.05 ? 127 LYS E CB  1 
ATOM 4447 C CG  . LYS C 2 121 ? 131.577 178.533 203.445 1.00 147.05 ? 127 LYS E CG  1 
ATOM 4448 C CD  . LYS C 2 121 ? 130.381 177.658 203.786 1.00 147.05 ? 127 LYS E CD  1 
ATOM 4449 C CE  . LYS C 2 121 ? 130.533 176.255 203.222 1.00 147.05 ? 127 LYS E CE  1 
ATOM 4450 N NZ  . LYS C 2 121 ? 130.857 176.263 201.771 1.00 147.05 ? 127 LYS E NZ  1 
# 
