data_8TN7
# 
_entry.id   8TN7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8TN7         pdb_00008tn7 10.2210/pdb8tn7/pdb 
WWPDB D_1000276246 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8TN7 
_pdbx_database_status.recvd_initial_deposition_date   2023-08-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              wlodawer@nih.gov 
_pdbx_contact_author.name_first         Alexander 
_pdbx_contact_author.name_last          Wlodawer 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5510-9703 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, M.'           1 ? 
'Wlodawer, A.'     2 ? 
'Temme, S.'        3 ? 
'Gildersleeve, J.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;An human dPNAG-specific Monoclonal Antibody Provides Protection from a Lethal S. aureus Changenge and Reveals Unique Biofilm Feature
;
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Temme, S.'        1 ? 
primary 'Li, M.'           2 ? 
primary 'Wlodawer, A.'     3 ? 
primary 'Gildersleeve, J.' 4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'TG10, heavy chain'                                                               23300.016 1   ? ? ? ? 
2 polymer     man 'TG10, Light chain'                                                               23576.996 1   ? ? ? ? 
3 branched    man '2-amino-2-deoxy-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-beta-D-glucopyranose' 340.327   1   ? ? ? ? 
4 non-polymer syn 'SULFATE ION'                                                                     96.063    9   ? ? ? ? 
5 non-polymer syn 'CHLORIDE ION'                                                                    35.453    1   ? ? ? ? 
6 water       nat water                                                                             18.015    472 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;EVQLVESGGGLVQPGGSLRLSCAVSGFPFSSYWMSWVRQAPGKGLEWVANIKEDGSEKYYVDSVKGRFTISRDNAKNSLY
LQMNSLRAEDTAVYYCATDPDVGLSDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS
;
;EVQLVESGGGLVQPGGSLRLSCAVSGFPFSSYWMSWVRQAPGKGLEWVANIKEDGSEKYYVDSVKGRFTISRDNAKNSLY
LQMNSLRAEDTAVYYCATDPDVGLSDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS
;
H ? 
2 'polypeptide(L)' no no 
;EIVLTQSPGTLSLSPGDRATHSCRASQSVSRSYLAWYQQKPGQTPRLFIYGASNRATGIPDRFSGSGSGTYFTLTISRLE
PEDFAVYYCQQYDSAPDTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
;
;EIVLTQSPGTLSLSPGDRATHSCRASQSVSRSYLAWYQQKPGQTPRLFIYGASNRATGIPDRFSGSGSGTYFTLTISRLE
PEDFAVYYCQQYDSAPDTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
;
L ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'SULFATE ION'  SO4 
5 'CHLORIDE ION' CL  
6 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLU n 
1 2   VAL n 
1 3   GLN n 
1 4   LEU n 
1 5   VAL n 
1 6   GLU n 
1 7   SER n 
1 8   GLY n 
1 9   GLY n 
1 10  GLY n 
1 11  LEU n 
1 12  VAL n 
1 13  GLN n 
1 14  PRO n 
1 15  GLY n 
1 16  GLY n 
1 17  SER n 
1 18  LEU n 
1 19  ARG n 
1 20  LEU n 
1 21  SER n 
1 22  CYS n 
1 23  ALA n 
1 24  VAL n 
1 25  SER n 
1 26  GLY n 
1 27  PHE n 
1 28  PRO n 
1 29  PHE n 
1 30  SER n 
1 31  SER n 
1 32  TYR n 
1 33  TRP n 
1 34  MET n 
1 35  SER n 
1 36  TRP n 
1 37  VAL n 
1 38  ARG n 
1 39  GLN n 
1 40  ALA n 
1 41  PRO n 
1 42  GLY n 
1 43  LYS n 
1 44  GLY n 
1 45  LEU n 
1 46  GLU n 
1 47  TRP n 
1 48  VAL n 
1 49  ALA n 
1 50  ASN n 
1 51  ILE n 
1 52  LYS n 
1 53  GLU n 
1 54  ASP n 
1 55  GLY n 
1 56  SER n 
1 57  GLU n 
1 58  LYS n 
1 59  TYR n 
1 60  TYR n 
1 61  VAL n 
1 62  ASP n 
1 63  SER n 
1 64  VAL n 
1 65  LYS n 
1 66  GLY n 
1 67  ARG n 
1 68  PHE n 
1 69  THR n 
1 70  ILE n 
1 71  SER n 
1 72  ARG n 
1 73  ASP n 
1 74  ASN n 
1 75  ALA n 
1 76  LYS n 
1 77  ASN n 
1 78  SER n 
1 79  LEU n 
1 80  TYR n 
1 81  LEU n 
1 82  GLN n 
1 83  MET n 
1 84  ASN n 
1 85  SER n 
1 86  LEU n 
1 87  ARG n 
1 88  ALA n 
1 89  GLU n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  VAL n 
1 94  TYR n 
1 95  TYR n 
1 96  CYS n 
1 97  ALA n 
1 98  THR n 
1 99  ASP n 
1 100 PRO n 
1 101 ASP n 
1 102 VAL n 
1 103 GLY n 
1 104 LEU n 
1 105 SER n 
1 106 ASP n 
1 107 SER n 
1 108 TRP n 
1 109 GLY n 
1 110 GLN n 
1 111 GLY n 
1 112 THR n 
1 113 LEU n 
1 114 VAL n 
1 115 THR n 
1 116 VAL n 
1 117 SER n 
1 118 SER n 
1 119 ALA n 
1 120 SER n 
1 121 THR n 
1 122 LYS n 
1 123 GLY n 
1 124 PRO n 
1 125 SER n 
1 126 VAL n 
1 127 PHE n 
1 128 PRO n 
1 129 LEU n 
1 130 ALA n 
1 131 PRO n 
1 132 SER n 
1 133 SER n 
1 134 LYS n 
1 135 SER n 
1 136 THR n 
1 137 SER n 
1 138 GLY n 
1 139 GLY n 
1 140 THR n 
1 141 ALA n 
1 142 ALA n 
1 143 LEU n 
1 144 GLY n 
1 145 CYS n 
1 146 LEU n 
1 147 VAL n 
1 148 LYS n 
1 149 ASP n 
1 150 TYR n 
1 151 PHE n 
1 152 PRO n 
1 153 GLU n 
1 154 PRO n 
1 155 VAL n 
1 156 THR n 
1 157 VAL n 
1 158 SER n 
1 159 TRP n 
1 160 ASN n 
1 161 SER n 
1 162 GLY n 
1 163 ALA n 
1 164 LEU n 
1 165 THR n 
1 166 SER n 
1 167 GLY n 
1 168 VAL n 
1 169 HIS n 
1 170 THR n 
1 171 PHE n 
1 172 PRO n 
1 173 ALA n 
1 174 VAL n 
1 175 LEU n 
1 176 GLN n 
1 177 SER n 
1 178 SER n 
1 179 GLY n 
1 180 LEU n 
1 181 TYR n 
1 182 SER n 
1 183 LEU n 
1 184 SER n 
1 185 SER n 
1 186 VAL n 
1 187 VAL n 
1 188 THR n 
1 189 VAL n 
1 190 PRO n 
1 191 SER n 
1 192 SER n 
1 193 SER n 
1 194 LEU n 
1 195 GLY n 
1 196 THR n 
1 197 GLN n 
1 198 THR n 
1 199 TYR n 
1 200 ILE n 
1 201 CYS n 
1 202 ASN n 
1 203 VAL n 
1 204 ASN n 
1 205 HIS n 
1 206 LYS n 
1 207 PRO n 
1 208 SER n 
1 209 ASN n 
1 210 THR n 
1 211 LYS n 
1 212 VAL n 
1 213 ASP n 
1 214 LYS n 
1 215 LYS n 
1 216 VAL n 
1 217 GLU n 
1 218 PRO n 
1 219 LYS n 
1 220 SER n 
2 1   GLU n 
2 2   ILE n 
2 3   VAL n 
2 4   LEU n 
2 5   THR n 
2 6   GLN n 
2 7   SER n 
2 8   PRO n 
2 9   GLY n 
2 10  THR n 
2 11  LEU n 
2 12  SER n 
2 13  LEU n 
2 14  SER n 
2 15  PRO n 
2 16  GLY n 
2 17  ASP n 
2 18  ARG n 
2 19  ALA n 
2 20  THR n 
2 21  HIS n 
2 22  SER n 
2 23  CYS n 
2 24  ARG n 
2 25  ALA n 
2 26  SER n 
2 27  GLN n 
2 28  SER n 
2 29  VAL n 
2 30  SER n 
2 31  ARG n 
2 32  SER n 
2 33  TYR n 
2 34  LEU n 
2 35  ALA n 
2 36  TRP n 
2 37  TYR n 
2 38  GLN n 
2 39  GLN n 
2 40  LYS n 
2 41  PRO n 
2 42  GLY n 
2 43  GLN n 
2 44  THR n 
2 45  PRO n 
2 46  ARG n 
2 47  LEU n 
2 48  PHE n 
2 49  ILE n 
2 50  TYR n 
2 51  GLY n 
2 52  ALA n 
2 53  SER n 
2 54  ASN n 
2 55  ARG n 
2 56  ALA n 
2 57  THR n 
2 58  GLY n 
2 59  ILE n 
2 60  PRO n 
2 61  ASP n 
2 62  ARG n 
2 63  PHE n 
2 64  SER n 
2 65  GLY n 
2 66  SER n 
2 67  GLY n 
2 68  SER n 
2 69  GLY n 
2 70  THR n 
2 71  TYR n 
2 72  PHE n 
2 73  THR n 
2 74  LEU n 
2 75  THR n 
2 76  ILE n 
2 77  SER n 
2 78  ARG n 
2 79  LEU n 
2 80  GLU n 
2 81  PRO n 
2 82  GLU n 
2 83  ASP n 
2 84  PHE n 
2 85  ALA n 
2 86  VAL n 
2 87  TYR n 
2 88  TYR n 
2 89  CYS n 
2 90  GLN n 
2 91  GLN n 
2 92  TYR n 
2 93  ASP n 
2 94  SER n 
2 95  ALA n 
2 96  PRO n 
2 97  ASP n 
2 98  THR n 
2 99  PHE n 
2 100 GLY n 
2 101 GLN n 
2 102 GLY n 
2 103 THR n 
2 104 ARG n 
2 105 LEU n 
2 106 GLU n 
2 107 ILE n 
2 108 LYS n 
2 109 ARG n 
2 110 THR n 
2 111 VAL n 
2 112 ALA n 
2 113 ALA n 
2 114 PRO n 
2 115 SER n 
2 116 VAL n 
2 117 PHE n 
2 118 ILE n 
2 119 PHE n 
2 120 PRO n 
2 121 PRO n 
2 122 SER n 
2 123 ASP n 
2 124 GLU n 
2 125 GLN n 
2 126 LEU n 
2 127 LYS n 
2 128 SER n 
2 129 GLY n 
2 130 THR n 
2 131 ALA n 
2 132 SER n 
2 133 VAL n 
2 134 VAL n 
2 135 CYS n 
2 136 LEU n 
2 137 LEU n 
2 138 ASN n 
2 139 ASN n 
2 140 PHE n 
2 141 TYR n 
2 142 PRO n 
2 143 ARG n 
2 144 GLU n 
2 145 ALA n 
2 146 LYS n 
2 147 VAL n 
2 148 GLN n 
2 149 TRP n 
2 150 LYS n 
2 151 VAL n 
2 152 ASP n 
2 153 ASN n 
2 154 ALA n 
2 155 LEU n 
2 156 GLN n 
2 157 SER n 
2 158 GLY n 
2 159 ASN n 
2 160 SER n 
2 161 GLN n 
2 162 GLU n 
2 163 SER n 
2 164 VAL n 
2 165 THR n 
2 166 GLU n 
2 167 GLN n 
2 168 ASP n 
2 169 SER n 
2 170 LYS n 
2 171 ASP n 
2 172 SER n 
2 173 THR n 
2 174 TYR n 
2 175 SER n 
2 176 LEU n 
2 177 SER n 
2 178 SER n 
2 179 THR n 
2 180 LEU n 
2 181 THR n 
2 182 LEU n 
2 183 SER n 
2 184 LYS n 
2 185 ALA n 
2 186 ASP n 
2 187 TYR n 
2 188 GLU n 
2 189 LYS n 
2 190 HIS n 
2 191 LYS n 
2 192 VAL n 
2 193 TYR n 
2 194 ALA n 
2 195 CYS n 
2 196 GLU n 
2 197 VAL n 
2 198 THR n 
2 199 HIS n 
2 200 GLN n 
2 201 GLY n 
2 202 LEU n 
2 203 SER n 
2 204 SER n 
2 205 PRO n 
2 206 VAL n 
2 207 THR n 
2 208 LYS n 
2 209 SER n 
2 210 PHE n 
2 211 ASN n 
2 212 ARG n 
2 213 GLY n 
2 214 GLU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 220 human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 214 human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   3 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 3 DGlcpNb1-6DGlcpNb1-ROH                          'Glycam Condensed Sequence' GMML       1.0   
2 3 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*N]/1-1/a6-b1' WURCS                       PDB2Glycan 1.1.0 
3 3 '[][b-D-GlcpN]{[(6+1)][b-D-GlcpN]{}}'           LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  3 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  GCS 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  GCS 
_pdbx_entity_branch_link.atom_id_2                  O6 
_pdbx_entity_branch_link.leaving_atom_id_2          HO6 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                              ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                             ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                           ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                      ? 'C4 H7 N O4'     133.103 
CL  non-polymer                  . 'CHLORIDE ION'                       ? 'Cl -1'          35.453  
CYS 'L-peptide linking'          y CYSTEINE                             ? 'C3 H7 N O2 S'   121.158 
GCS 'D-saccharide, beta linking' . 2-amino-2-deoxy-beta-D-glucopyranose 
'beta-D-glucosamine; 2-amino-2-deoxy-beta-D-glucose; 2-amino-2-deoxy-D-glucose; 2-amino-2-deoxy-glucose; D-GLUCOSAMINE' 
'C6 H13 N O5'    179.171 
GLN 'L-peptide linking'          y GLUTAMINE                            ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                      ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                              ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                            ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                           ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                              ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                               ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                           ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking'          y PHENYLALANINE                        ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                              ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                               ? 'C3 H7 N O3'     105.093 
SO4 non-polymer                  . 'SULFATE ION'                        ? 'O4 S -2'        96.063  
THR 'L-peptide linking'          y THREONINE                            ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                           ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                             ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                               ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
GCS 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNb               
GCS 'COMMON NAME'                         GMML     1.0 b-D-glucopyranosamine 
GCS 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpN             
GCS 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcN                  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLU 1   1   1   GLU GLU H . n 
A 1 2   VAL 2   2   2   VAL VAL H . n 
A 1 3   GLN 3   3   3   GLN GLN H . n 
A 1 4   LEU 4   4   4   LEU LEU H . n 
A 1 5   VAL 5   5   5   VAL VAL H . n 
A 1 6   GLU 6   6   6   GLU GLU H . n 
A 1 7   SER 7   7   7   SER SER H . n 
A 1 8   GLY 8   8   8   GLY GLY H . n 
A 1 9   GLY 9   9   9   GLY GLY H . n 
A 1 10  GLY 10  11  11  GLY GLY H . n 
A 1 11  LEU 11  12  12  LEU LEU H . n 
A 1 12  VAL 12  13  13  VAL VAL H . n 
A 1 13  GLN 13  14  14  GLN GLN H . n 
A 1 14  PRO 14  15  15  PRO PRO H . n 
A 1 15  GLY 15  16  16  GLY GLY H . n 
A 1 16  GLY 16  17  17  GLY GLY H . n 
A 1 17  SER 17  18  18  SER SER H . n 
A 1 18  LEU 18  19  19  LEU LEU H . n 
A 1 19  ARG 19  20  20  ARG ARG H . n 
A 1 20  LEU 20  21  21  LEU LEU H . n 
A 1 21  SER 21  22  22  SER SER H . n 
A 1 22  CYS 22  23  23  CYS CYS H . n 
A 1 23  ALA 23  24  24  ALA ALA H . n 
A 1 24  VAL 24  25  25  VAL VAL H . n 
A 1 25  SER 25  26  26  SER SER H . n 
A 1 26  GLY 26  27  27  GLY GLY H . n 
A 1 27  PHE 27  28  28  PHE PHE H . n 
A 1 28  PRO 28  29  29  PRO PRO H . n 
A 1 29  PHE 29  30  30  PHE PHE H . n 
A 1 30  SER 30  35  35  SER SER H . n 
A 1 31  SER 31  36  36  SER SER H . n 
A 1 32  TYR 32  37  37  TYR TYR H . n 
A 1 33  TRP 33  38  38  TRP TRP H . n 
A 1 34  MET 34  39  39  MET MET H . n 
A 1 35  SER 35  40  40  SER SER H . n 
A 1 36  TRP 36  41  41  TRP TRP H . n 
A 1 37  VAL 37  42  42  VAL VAL H . n 
A 1 38  ARG 38  43  43  ARG ARG H . n 
A 1 39  GLN 39  44  44  GLN GLN H . n 
A 1 40  ALA 40  45  45  ALA ALA H . n 
A 1 41  PRO 41  46  46  PRO PRO H . n 
A 1 42  GLY 42  47  47  GLY GLY H . n 
A 1 43  LYS 43  48  48  LYS LYS H . n 
A 1 44  GLY 44  49  49  GLY GLY H . n 
A 1 45  LEU 45  50  50  LEU LEU H . n 
A 1 46  GLU 46  51  51  GLU GLU H . n 
A 1 47  TRP 47  52  52  TRP TRP H . n 
A 1 48  VAL 48  53  53  VAL VAL H . n 
A 1 49  ALA 49  54  54  ALA ALA H . n 
A 1 50  ASN 50  55  55  ASN ASN H . n 
A 1 51  ILE 51  56  56  ILE ILE H . n 
A 1 52  LYS 52  57  57  LYS LYS H . n 
A 1 53  GLU 53  58  58  GLU GLU H . n 
A 1 54  ASP 54  59  59  ASP ASP H . n 
A 1 55  GLY 55  62  62  GLY GLY H . n 
A 1 56  SER 56  63  63  SER SER H . n 
A 1 57  GLU 57  64  64  GLU GLU H . n 
A 1 58  LYS 58  65  65  LYS LYS H . n 
A 1 59  TYR 59  66  66  TYR TYR H . n 
A 1 60  TYR 60  67  67  TYR TYR H . n 
A 1 61  VAL 61  68  68  VAL VAL H . n 
A 1 62  ASP 62  69  69  ASP ASP H . n 
A 1 63  SER 63  70  70  SER SER H . n 
A 1 64  VAL 64  71  71  VAL VAL H . n 
A 1 65  LYS 65  72  72  LYS LYS H . n 
A 1 66  GLY 66  74  74  GLY GLY H . n 
A 1 67  ARG 67  75  75  ARG ARG H . n 
A 1 68  PHE 68  76  76  PHE PHE H . n 
A 1 69  THR 69  77  77  THR THR H . n 
A 1 70  ILE 70  78  78  ILE ILE H . n 
A 1 71  SER 71  79  79  SER SER H . n 
A 1 72  ARG 72  80  80  ARG ARG H . n 
A 1 73  ASP 73  81  81  ASP ASP H . n 
A 1 74  ASN 74  82  82  ASN ASN H . n 
A 1 75  ALA 75  83  83  ALA ALA H . n 
A 1 76  LYS 76  84  84  LYS LYS H . n 
A 1 77  ASN 77  85  85  ASN ASN H . n 
A 1 78  SER 78  86  86  SER SER H . n 
A 1 79  LEU 79  87  87  LEU LEU H . n 
A 1 80  TYR 80  88  88  TYR TYR H . n 
A 1 81  LEU 81  89  89  LEU LEU H . n 
A 1 82  GLN 82  90  90  GLN GLN H . n 
A 1 83  MET 83  91  91  MET MET H . n 
A 1 84  ASN 84  92  92  ASN ASN H . n 
A 1 85  SER 85  93  93  SER SER H . n 
A 1 86  LEU 86  94  94  LEU LEU H . n 
A 1 87  ARG 87  95  95  ARG ARG H . n 
A 1 88  ALA 88  96  96  ALA ALA H . n 
A 1 89  GLU 89  97  97  GLU GLU H . n 
A 1 90  ASP 90  98  98  ASP ASP H . n 
A 1 91  THR 91  99  99  THR THR H . n 
A 1 92  ALA 92  100 100 ALA ALA H . n 
A 1 93  VAL 93  101 101 VAL VAL H . n 
A 1 94  TYR 94  102 102 TYR TYR H . n 
A 1 95  TYR 95  103 103 TYR TYR H . n 
A 1 96  CYS 96  104 104 CYS CYS H . n 
A 1 97  ALA 97  105 105 ALA ALA H . n 
A 1 98  THR 98  106 106 THR THR H . n 
A 1 99  ASP 99  107 107 ASP ASP H . n 
A 1 100 PRO 100 108 108 PRO PRO H . n 
A 1 101 ASP 101 109 109 ASP ASP H . n 
A 1 102 VAL 102 110 110 VAL VAL H . n 
A 1 103 GLY 103 113 113 GLY GLY H . n 
A 1 104 LEU 104 114 114 LEU LEU H . n 
A 1 105 SER 105 115 115 SER SER H . n 
A 1 106 ASP 106 116 116 ASP ASP H . n 
A 1 107 SER 107 117 117 SER SER H . n 
A 1 108 TRP 108 118 118 TRP TRP H . n 
A 1 109 GLY 109 119 119 GLY GLY H . n 
A 1 110 GLN 110 120 120 GLN GLN H . n 
A 1 111 GLY 111 121 121 GLY GLY H . n 
A 1 112 THR 112 122 122 THR THR H . n 
A 1 113 LEU 113 123 123 LEU LEU H . n 
A 1 114 VAL 114 124 124 VAL VAL H . n 
A 1 115 THR 115 125 125 THR THR H . n 
A 1 116 VAL 116 126 126 VAL VAL H . n 
A 1 117 SER 117 127 127 SER SER H . n 
A 1 118 SER 118 128 128 SER SER H . n 
A 1 119 ALA 119 129 129 ALA ALA H . n 
A 1 120 SER 120 130 130 SER SER H . n 
A 1 121 THR 121 131 131 THR THR H . n 
A 1 122 LYS 122 132 132 LYS LYS H . n 
A 1 123 GLY 123 133 133 GLY GLY H . n 
A 1 124 PRO 124 134 134 PRO PRO H . n 
A 1 125 SER 125 135 135 SER SER H . n 
A 1 126 VAL 126 136 136 VAL VAL H . n 
A 1 127 PHE 127 137 137 PHE PHE H . n 
A 1 128 PRO 128 138 138 PRO PRO H . n 
A 1 129 LEU 129 139 139 LEU LEU H . n 
A 1 130 ALA 130 140 140 ALA ALA H . n 
A 1 131 PRO 131 141 141 PRO PRO H . n 
A 1 132 SER 132 142 142 SER SER H . n 
A 1 133 SER 133 143 143 SER SER H . n 
A 1 134 LYS 134 144 144 LYS LYS H . n 
A 1 135 SER 135 145 145 SER SER H . n 
A 1 136 THR 136 146 146 THR THR H . n 
A 1 137 SER 137 147 147 SER SER H . n 
A 1 138 GLY 138 148 148 GLY GLY H . n 
A 1 139 GLY 139 149 149 GLY GLY H . n 
A 1 140 THR 140 150 150 THR THR H . n 
A 1 141 ALA 141 151 151 ALA ALA H . n 
A 1 142 ALA 142 152 152 ALA ALA H . n 
A 1 143 LEU 143 153 153 LEU LEU H . n 
A 1 144 GLY 144 154 154 GLY GLY H . n 
A 1 145 CYS 145 155 155 CYS CYS H . n 
A 1 146 LEU 146 156 156 LEU LEU H . n 
A 1 147 VAL 147 157 157 VAL VAL H . n 
A 1 148 LYS 148 158 158 LYS LYS H . n 
A 1 149 ASP 149 159 159 ASP ASP H . n 
A 1 150 TYR 150 160 160 TYR TYR H . n 
A 1 151 PHE 151 161 161 PHE PHE H . n 
A 1 152 PRO 152 162 162 PRO PRO H . n 
A 1 153 GLU 153 163 163 GLU GLU H . n 
A 1 154 PRO 154 164 164 PRO PRO H . n 
A 1 155 VAL 155 165 165 VAL VAL H . n 
A 1 156 THR 156 166 166 THR THR H . n 
A 1 157 VAL 157 167 167 VAL VAL H . n 
A 1 158 SER 158 168 168 SER SER H . n 
A 1 159 TRP 159 169 169 TRP TRP H . n 
A 1 160 ASN 160 170 170 ASN ASN H . n 
A 1 161 SER 161 171 171 SER SER H . n 
A 1 162 GLY 162 172 172 GLY GLY H . n 
A 1 163 ALA 163 173 173 ALA ALA H . n 
A 1 164 LEU 164 174 174 LEU LEU H . n 
A 1 165 THR 165 175 175 THR THR H . n 
A 1 166 SER 166 176 176 SER SER H . n 
A 1 167 GLY 167 177 177 GLY GLY H . n 
A 1 168 VAL 168 178 178 VAL VAL H . n 
A 1 169 HIS 169 179 179 HIS HIS H . n 
A 1 170 THR 170 180 180 THR THR H . n 
A 1 171 PHE 171 181 181 PHE PHE H . n 
A 1 172 PRO 172 182 182 PRO PRO H . n 
A 1 173 ALA 173 183 183 ALA ALA H . n 
A 1 174 VAL 174 184 184 VAL VAL H . n 
A 1 175 LEU 175 185 185 LEU LEU H . n 
A 1 176 GLN 176 186 186 GLN GLN H . n 
A 1 177 SER 177 187 187 SER SER H . n 
A 1 178 SER 178 188 188 SER SER H . n 
A 1 179 GLY 179 189 189 GLY GLY H . n 
A 1 180 LEU 180 190 190 LEU LEU H . n 
A 1 181 TYR 181 191 191 TYR TYR H . n 
A 1 182 SER 182 192 192 SER SER H . n 
A 1 183 LEU 183 193 193 LEU LEU H . n 
A 1 184 SER 184 194 194 SER SER H . n 
A 1 185 SER 185 195 195 SER SER H . n 
A 1 186 VAL 186 196 196 VAL VAL H . n 
A 1 187 VAL 187 197 197 VAL VAL H . n 
A 1 188 THR 188 198 198 THR THR H . n 
A 1 189 VAL 189 199 199 VAL VAL H . n 
A 1 190 PRO 190 200 200 PRO PRO H . n 
A 1 191 SER 191 201 201 SER SER H . n 
A 1 192 SER 192 202 202 SER SER H . n 
A 1 193 SER 193 203 203 SER SER H . n 
A 1 194 LEU 194 204 204 LEU LEU H . n 
A 1 195 GLY 195 205 205 GLY GLY H . n 
A 1 196 THR 196 206 206 THR THR H . n 
A 1 197 GLN 197 207 207 GLN GLN H . n 
A 1 198 THR 198 208 208 THR THR H . n 
A 1 199 TYR 199 209 209 TYR TYR H . n 
A 1 200 ILE 200 210 210 ILE ILE H . n 
A 1 201 CYS 201 211 211 CYS CYS H . n 
A 1 202 ASN 202 212 212 ASN ASN H . n 
A 1 203 VAL 203 213 213 VAL VAL H . n 
A 1 204 ASN 204 214 214 ASN ASN H . n 
A 1 205 HIS 205 215 215 HIS HIS H . n 
A 1 206 LYS 206 216 216 LYS LYS H . n 
A 1 207 PRO 207 217 217 PRO PRO H . n 
A 1 208 SER 208 218 218 SER SER H . n 
A 1 209 ASN 209 219 219 ASN ASN H . n 
A 1 210 THR 210 220 220 THR THR H . n 
A 1 211 LYS 211 221 221 LYS LYS H . n 
A 1 212 VAL 212 222 222 VAL VAL H . n 
A 1 213 ASP 213 223 223 ASP ASP H . n 
A 1 214 LYS 214 224 224 LYS LYS H . n 
A 1 215 LYS 215 225 225 LYS LYS H . n 
A 1 216 VAL 216 226 226 VAL VAL H . n 
A 1 217 GLU 217 227 227 GLU GLU H . n 
A 1 218 PRO 218 228 228 PRO PRO H . n 
A 1 219 LYS 219 229 229 LYS LYS H . n 
A 1 220 SER 220 230 230 SER SER H . n 
B 2 1   GLU 1   1   1   GLU GLU L . n 
B 2 2   ILE 2   2   2   ILE ILE L . n 
B 2 3   VAL 3   3   3   VAL VAL L . n 
B 2 4   LEU 4   4   4   LEU LEU L . n 
B 2 5   THR 5   5   5   THR THR L . n 
B 2 6   GLN 6   6   6   GLN GLN L . n 
B 2 7   SER 7   7   7   SER SER L . n 
B 2 8   PRO 8   8   8   PRO PRO L . n 
B 2 9   GLY 9   9   9   GLY GLY L . n 
B 2 10  THR 10  10  10  THR THR L . n 
B 2 11  LEU 11  11  11  LEU LEU L . n 
B 2 12  SER 12  12  12  SER SER L . n 
B 2 13  LEU 13  13  13  LEU LEU L . n 
B 2 14  SER 14  14  14  SER SER L . n 
B 2 15  PRO 15  15  15  PRO PRO L . n 
B 2 16  GLY 16  16  16  GLY GLY L . n 
B 2 17  ASP 17  17  17  ASP ASP L . n 
B 2 18  ARG 18  18  18  ARG ARG L . n 
B 2 19  ALA 19  19  19  ALA ALA L . n 
B 2 20  THR 20  20  20  THR THR L . n 
B 2 21  HIS 21  21  21  HIS HIS L . n 
B 2 22  SER 22  22  22  SER SER L . n 
B 2 23  CYS 23  23  23  CYS CYS L . n 
B 2 24  ARG 24  24  24  ARG ARG L . n 
B 2 25  ALA 25  25  25  ALA ALA L . n 
B 2 26  SER 26  26  26  SER SER L . n 
B 2 27  GLN 27  27  27  GLN GLN L . n 
B 2 28  SER 28  28  28  SER SER L . n 
B 2 29  VAL 29  29  29  VAL VAL L . n 
B 2 30  SER 30  30  30  SER SER L . n 
B 2 31  ARG 31  36  36  ARG ARG L . n 
B 2 32  SER 32  37  37  SER SER L . n 
B 2 33  TYR 33  38  38  TYR TYR L . n 
B 2 34  LEU 34  39  39  LEU LEU L . n 
B 2 35  ALA 35  40  40  ALA ALA L . n 
B 2 36  TRP 36  41  41  TRP TRP L . n 
B 2 37  TYR 37  42  42  TYR TYR L . n 
B 2 38  GLN 38  43  43  GLN GLN L . n 
B 2 39  GLN 39  44  44  GLN GLN L . n 
B 2 40  LYS 40  45  45  LYS LYS L . n 
B 2 41  PRO 41  46  46  PRO PRO L . n 
B 2 42  GLY 42  47  47  GLY GLY L . n 
B 2 43  GLN 43  48  48  GLN GLN L . n 
B 2 44  THR 44  49  49  THR THR L . n 
B 2 45  PRO 45  50  50  PRO PRO L . n 
B 2 46  ARG 46  51  51  ARG ARG L . n 
B 2 47  LEU 47  52  52  LEU LEU L . n 
B 2 48  PHE 48  53  53  PHE PHE L . n 
B 2 49  ILE 49  54  54  ILE ILE L . n 
B 2 50  TYR 50  55  55  TYR TYR L . n 
B 2 51  GLY 51  56  56  GLY GLY L . n 
B 2 52  ALA 52  57  57  ALA ALA L . n 
B 2 53  SER 53  65  65  SER SER L . n 
B 2 54  ASN 54  66  66  ASN ASN L . n 
B 2 55  ARG 55  67  67  ARG ARG L . n 
B 2 56  ALA 56  68  68  ALA ALA L . n 
B 2 57  THR 57  69  69  THR THR L . n 
B 2 58  GLY 58  70  70  GLY GLY L . n 
B 2 59  ILE 59  71  71  ILE ILE L . n 
B 2 60  PRO 60  72  72  PRO PRO L . n 
B 2 61  ASP 61  74  74  ASP ASP L . n 
B 2 62  ARG 62  75  75  ARG ARG L . n 
B 2 63  PHE 63  76  76  PHE PHE L . n 
B 2 64  SER 64  77  77  SER SER L . n 
B 2 65  GLY 65  78  78  GLY GLY L . n 
B 2 66  SER 66  79  79  SER SER L . n 
B 2 67  GLY 67  80  80  GLY GLY L . n 
B 2 68  SER 68  83  83  SER SER L . n 
B 2 69  GLY 69  84  84  GLY GLY L . n 
B 2 70  THR 70  85  85  THR THR L . n 
B 2 71  TYR 71  86  86  TYR TYR L . n 
B 2 72  PHE 72  87  87  PHE PHE L . n 
B 2 73  THR 73  88  88  THR THR L . n 
B 2 74  LEU 74  89  89  LEU LEU L . n 
B 2 75  THR 75  90  90  THR THR L . n 
B 2 76  ILE 76  91  91  ILE ILE L . n 
B 2 77  SER 77  92  92  SER SER L . n 
B 2 78  ARG 78  93  93  ARG ARG L . n 
B 2 79  LEU 79  94  94  LEU LEU L . n 
B 2 80  GLU 80  95  95  GLU GLU L . n 
B 2 81  PRO 81  96  96  PRO PRO L . n 
B 2 82  GLU 82  97  97  GLU GLU L . n 
B 2 83  ASP 83  98  98  ASP ASP L . n 
B 2 84  PHE 84  99  99  PHE PHE L . n 
B 2 85  ALA 85  100 100 ALA ALA L . n 
B 2 86  VAL 86  101 101 VAL VAL L . n 
B 2 87  TYR 87  102 102 TYR TYR L . n 
B 2 88  TYR 88  103 103 TYR TYR L . n 
B 2 89  CYS 89  104 104 CYS CYS L . n 
B 2 90  GLN 90  105 105 GLN GLN L . n 
B 2 91  GLN 91  106 106 GLN GLN L . n 
B 2 92  TYR 92  107 107 TYR TYR L . n 
B 2 93  ASP 93  108 108 ASP ASP L . n 
B 2 94  SER 94  109 109 SER SER L . n 
B 2 95  ALA 95  114 114 ALA ALA L . n 
B 2 96  PRO 96  115 115 PRO PRO L . n 
B 2 97  ASP 97  116 116 ASP ASP L . n 
B 2 98  THR 98  117 117 THR THR L . n 
B 2 99  PHE 99  118 118 PHE PHE L . n 
B 2 100 GLY 100 119 119 GLY GLY L . n 
B 2 101 GLN 101 120 120 GLN GLN L . n 
B 2 102 GLY 102 121 121 GLY GLY L . n 
B 2 103 THR 103 122 122 THR THR L . n 
B 2 104 ARG 104 123 123 ARG ARG L . n 
B 2 105 LEU 105 124 124 LEU LEU L . n 
B 2 106 GLU 106 125 125 GLU GLU L . n 
B 2 107 ILE 107 126 126 ILE ILE L . n 
B 2 108 LYS 108 127 127 LYS LYS L . n 
B 2 109 ARG 109 128 128 ARG ARG L . n 
B 2 110 THR 110 129 129 THR THR L . n 
B 2 111 VAL 111 130 130 VAL VAL L . n 
B 2 112 ALA 112 131 131 ALA ALA L . n 
B 2 113 ALA 113 132 132 ALA ALA L . n 
B 2 114 PRO 114 133 133 PRO PRO L . n 
B 2 115 SER 115 134 134 SER SER L . n 
B 2 116 VAL 116 135 135 VAL VAL L . n 
B 2 117 PHE 117 136 136 PHE PHE L . n 
B 2 118 ILE 118 137 137 ILE ILE L . n 
B 2 119 PHE 119 138 138 PHE PHE L . n 
B 2 120 PRO 120 139 139 PRO PRO L . n 
B 2 121 PRO 121 140 140 PRO PRO L . n 
B 2 122 SER 122 141 141 SER SER L . n 
B 2 123 ASP 123 142 142 ASP ASP L . n 
B 2 124 GLU 124 143 143 GLU GLU L . n 
B 2 125 GLN 125 144 144 GLN GLN L . n 
B 2 126 LEU 126 145 145 LEU LEU L . n 
B 2 127 LYS 127 146 146 LYS LYS L . n 
B 2 128 SER 128 147 147 SER SER L . n 
B 2 129 GLY 129 148 148 GLY GLY L . n 
B 2 130 THR 130 149 149 THR THR L . n 
B 2 131 ALA 131 150 150 ALA ALA L . n 
B 2 132 SER 132 151 151 SER SER L . n 
B 2 133 VAL 133 152 152 VAL VAL L . n 
B 2 134 VAL 134 153 153 VAL VAL L . n 
B 2 135 CYS 135 154 154 CYS CYS L . n 
B 2 136 LEU 136 155 155 LEU LEU L . n 
B 2 137 LEU 137 156 156 LEU LEU L . n 
B 2 138 ASN 138 157 157 ASN ASN L . n 
B 2 139 ASN 139 158 158 ASN ASN L . n 
B 2 140 PHE 140 159 159 PHE PHE L . n 
B 2 141 TYR 141 160 160 TYR TYR L . n 
B 2 142 PRO 142 161 161 PRO PRO L . n 
B 2 143 ARG 143 162 162 ARG ARG L . n 
B 2 144 GLU 144 163 163 GLU GLU L . n 
B 2 145 ALA 145 164 164 ALA ALA L . n 
B 2 146 LYS 146 165 165 LYS LYS L . n 
B 2 147 VAL 147 166 166 VAL VAL L . n 
B 2 148 GLN 148 167 167 GLN GLN L . n 
B 2 149 TRP 149 168 168 TRP TRP L . n 
B 2 150 LYS 150 169 169 LYS LYS L . n 
B 2 151 VAL 151 170 170 VAL VAL L . n 
B 2 152 ASP 152 171 171 ASP ASP L . n 
B 2 153 ASN 153 172 172 ASN ASN L . n 
B 2 154 ALA 154 173 173 ALA ALA L . n 
B 2 155 LEU 155 174 174 LEU LEU L . n 
B 2 156 GLN 156 175 175 GLN GLN L . n 
B 2 157 SER 157 176 176 SER SER L . n 
B 2 158 GLY 158 177 177 GLY GLY L . n 
B 2 159 ASN 159 178 178 ASN ASN L . n 
B 2 160 SER 160 179 179 SER SER L . n 
B 2 161 GLN 161 180 180 GLN GLN L . n 
B 2 162 GLU 162 181 181 GLU GLU L . n 
B 2 163 SER 163 182 182 SER SER L . n 
B 2 164 VAL 164 183 183 VAL VAL L . n 
B 2 165 THR 165 184 184 THR THR L . n 
B 2 166 GLU 166 185 185 GLU GLU L . n 
B 2 167 GLN 167 186 186 GLN GLN L . n 
B 2 168 ASP 168 187 187 ASP ASP L . n 
B 2 169 SER 169 188 188 SER SER L . n 
B 2 170 LYS 170 189 189 LYS LYS L . n 
B 2 171 ASP 171 190 190 ASP ASP L . n 
B 2 172 SER 172 191 191 SER SER L . n 
B 2 173 THR 173 192 192 THR THR L . n 
B 2 174 TYR 174 193 193 TYR TYR L . n 
B 2 175 SER 175 194 194 SER SER L . n 
B 2 176 LEU 176 195 195 LEU LEU L . n 
B 2 177 SER 177 196 196 SER SER L . n 
B 2 178 SER 178 197 197 SER SER L . n 
B 2 179 THR 179 198 198 THR THR L . n 
B 2 180 LEU 180 199 199 LEU LEU L . n 
B 2 181 THR 181 200 200 THR THR L . n 
B 2 182 LEU 182 201 201 LEU LEU L . n 
B 2 183 SER 183 202 202 SER SER L . n 
B 2 184 LYS 184 203 203 LYS LYS L . n 
B 2 185 ALA 185 204 204 ALA ALA L . n 
B 2 186 ASP 186 205 205 ASP ASP L . n 
B 2 187 TYR 187 206 206 TYR TYR L . n 
B 2 188 GLU 188 207 207 GLU GLU L . n 
B 2 189 LYS 189 208 208 LYS LYS L . n 
B 2 190 HIS 190 209 209 HIS HIS L . n 
B 2 191 LYS 191 210 210 LYS LYS L . n 
B 2 192 VAL 192 211 211 VAL VAL L . n 
B 2 193 TYR 193 212 212 TYR TYR L . n 
B 2 194 ALA 194 213 213 ALA ALA L . n 
B 2 195 CYS 195 214 214 CYS CYS L . n 
B 2 196 GLU 196 215 215 GLU GLU L . n 
B 2 197 VAL 197 216 216 VAL VAL L . n 
B 2 198 THR 198 217 217 THR THR L . n 
B 2 199 HIS 199 218 218 HIS HIS L . n 
B 2 200 GLN 200 219 219 GLN GLN L . n 
B 2 201 GLY 201 220 220 GLY GLY L . n 
B 2 202 LEU 202 221 221 LEU LEU L . n 
B 2 203 SER 203 222 222 SER SER L . n 
B 2 204 SER 204 223 223 SER SER L . n 
B 2 205 PRO 205 224 224 PRO PRO L . n 
B 2 206 VAL 206 225 225 VAL VAL L . n 
B 2 207 THR 207 226 226 THR THR L . n 
B 2 208 LYS 208 227 227 LYS LYS L . n 
B 2 209 SER 209 228 228 SER SER L . n 
B 2 210 PHE 210 229 229 PHE PHE L . n 
B 2 211 ASN 211 230 230 ASN ASN L . n 
B 2 212 ARG 212 231 231 ARG ARG L . n 
B 2 213 GLY 213 232 232 GLY GLY L . n 
B 2 214 GLU 214 233 233 GLU GLU L . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
C 3 GCS 1 A GCS 1 A GCS 1 n 
C 3 GCS 2 A GCS 2 A GCS 2 n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        GCS 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   GCS 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 SO4 1   301 4   SO4 SO4 H . 
E 4 SO4 1   302 5   SO4 SO4 H . 
F 4 SO4 1   303 8   SO4 SO4 H . 
G 4 SO4 1   304 9   SO4 SO4 H . 
H 5 CL  1   305 11  CL  CL  H . 
I 4 SO4 1   301 1   SO4 SO4 L . 
J 4 SO4 1   302 2   SO4 SO4 L . 
K 4 SO4 1   303 3   SO4 SO4 L . 
L 4 SO4 1   304 7   SO4 SO4 L . 
M 4 SO4 1   305 10  SO4 SO4 L . 
N 6 HOH 1   401 455 HOH HOH H . 
N 6 HOH 2   402 454 HOH HOH H . 
N 6 HOH 3   403 438 HOH HOH H . 
N 6 HOH 4   404 422 HOH HOH H . 
N 6 HOH 5   405 376 HOH HOH H . 
N 6 HOH 6   406 412 HOH HOH H . 
N 6 HOH 7   407 472 HOH HOH H . 
N 6 HOH 8   408 257 HOH HOH H . 
N 6 HOH 9   409 453 HOH HOH H . 
N 6 HOH 10  410 417 HOH HOH H . 
N 6 HOH 11  411 134 HOH HOH H . 
N 6 HOH 12  412 434 HOH HOH H . 
N 6 HOH 13  413 205 HOH HOH H . 
N 6 HOH 14  414 303 HOH HOH H . 
N 6 HOH 15  415 315 HOH HOH H . 
N 6 HOH 16  416 268 HOH HOH H . 
N 6 HOH 17  417 286 HOH HOH H . 
N 6 HOH 18  418 228 HOH HOH H . 
N 6 HOH 19  419 364 HOH HOH H . 
N 6 HOH 20  420 37  HOH HOH H . 
N 6 HOH 21  421 452 HOH HOH H . 
N 6 HOH 22  422 369 HOH HOH H . 
N 6 HOH 23  423 49  HOH HOH H . 
N 6 HOH 24  424 462 HOH HOH H . 
N 6 HOH 25  425 209 HOH HOH H . 
N 6 HOH 26  426 171 HOH HOH H . 
N 6 HOH 27  427 354 HOH HOH H . 
N 6 HOH 28  428 302 HOH HOH H . 
N 6 HOH 29  429 238 HOH HOH H . 
N 6 HOH 30  430 317 HOH HOH H . 
N 6 HOH 31  431 76  HOH HOH H . 
N 6 HOH 32  432 123 HOH HOH H . 
N 6 HOH 33  433 115 HOH HOH H . 
N 6 HOH 34  434 40  HOH HOH H . 
N 6 HOH 35  435 135 HOH HOH H . 
N 6 HOH 36  436 188 HOH HOH H . 
N 6 HOH 37  437 378 HOH HOH H . 
N 6 HOH 38  438 240 HOH HOH H . 
N 6 HOH 39  439 153 HOH HOH H . 
N 6 HOH 40  440 61  HOH HOH H . 
N 6 HOH 41  441 166 HOH HOH H . 
N 6 HOH 42  442 254 HOH HOH H . 
N 6 HOH 43  443 21  HOH HOH H . 
N 6 HOH 44  444 48  HOH HOH H . 
N 6 HOH 45  445 358 HOH HOH H . 
N 6 HOH 46  446 419 HOH HOH H . 
N 6 HOH 47  447 11  HOH HOH H . 
N 6 HOH 48  448 304 HOH HOH H . 
N 6 HOH 49  449 109 HOH HOH H . 
N 6 HOH 50  450 213 HOH HOH H . 
N 6 HOH 51  451 292 HOH HOH H . 
N 6 HOH 52  452 43  HOH HOH H . 
N 6 HOH 53  453 19  HOH HOH H . 
N 6 HOH 54  454 112 HOH HOH H . 
N 6 HOH 55  455 88  HOH HOH H . 
N 6 HOH 56  456 106 HOH HOH H . 
N 6 HOH 57  457 183 HOH HOH H . 
N 6 HOH 58  458 251 HOH HOH H . 
N 6 HOH 59  459 246 HOH HOH H . 
N 6 HOH 60  460 176 HOH HOH H . 
N 6 HOH 61  461 343 HOH HOH H . 
N 6 HOH 62  462 298 HOH HOH H . 
N 6 HOH 63  463 193 HOH HOH H . 
N 6 HOH 64  464 328 HOH HOH H . 
N 6 HOH 65  465 271 HOH HOH H . 
N 6 HOH 66  466 414 HOH HOH H . 
N 6 HOH 67  467 295 HOH HOH H . 
N 6 HOH 68  468 415 HOH HOH H . 
N 6 HOH 69  469 127 HOH HOH H . 
N 6 HOH 70  470 167 HOH HOH H . 
N 6 HOH 71  471 89  HOH HOH H . 
N 6 HOH 72  472 420 HOH HOH H . 
N 6 HOH 73  473 301 HOH HOH H . 
N 6 HOH 74  474 320 HOH HOH H . 
N 6 HOH 75  475 416 HOH HOH H . 
N 6 HOH 76  476 105 HOH HOH H . 
N 6 HOH 77  477 179 HOH HOH H . 
N 6 HOH 78  478 98  HOH HOH H . 
N 6 HOH 79  479 121 HOH HOH H . 
N 6 HOH 80  480 164 HOH HOH H . 
N 6 HOH 81  481 144 HOH HOH H . 
N 6 HOH 82  482 197 HOH HOH H . 
N 6 HOH 83  483 46  HOH HOH H . 
N 6 HOH 84  484 293 HOH HOH H . 
N 6 HOH 85  485 25  HOH HOH H . 
N 6 HOH 86  486 163 HOH HOH H . 
N 6 HOH 87  487 128 HOH HOH H . 
N 6 HOH 88  488 411 HOH HOH H . 
N 6 HOH 89  489 38  HOH HOH H . 
N 6 HOH 90  490 280 HOH HOH H . 
N 6 HOH 91  491 86  HOH HOH H . 
N 6 HOH 92  492 314 HOH HOH H . 
N 6 HOH 93  493 131 HOH HOH H . 
N 6 HOH 94  494 334 HOH HOH H . 
N 6 HOH 95  495 381 HOH HOH H . 
N 6 HOH 96  496 256 HOH HOH H . 
N 6 HOH 97  497 57  HOH HOH H . 
N 6 HOH 98  498 20  HOH HOH H . 
N 6 HOH 99  499 198 HOH HOH H . 
N 6 HOH 100 500 18  HOH HOH H . 
N 6 HOH 101 501 233 HOH HOH H . 
N 6 HOH 102 502 325 HOH HOH H . 
N 6 HOH 103 503 392 HOH HOH H . 
N 6 HOH 104 504 281 HOH HOH H . 
N 6 HOH 105 505 149 HOH HOH H . 
N 6 HOH 106 506 162 HOH HOH H . 
N 6 HOH 107 507 259 HOH HOH H . 
N 6 HOH 108 508 223 HOH HOH H . 
N 6 HOH 109 509 339 HOH HOH H . 
N 6 HOH 110 510 42  HOH HOH H . 
N 6 HOH 111 511 60  HOH HOH H . 
N 6 HOH 112 512 355 HOH HOH H . 
N 6 HOH 113 513 356 HOH HOH H . 
N 6 HOH 114 514 329 HOH HOH H . 
N 6 HOH 115 515 429 HOH HOH H . 
N 6 HOH 116 516 224 HOH HOH H . 
N 6 HOH 117 517 218 HOH HOH H . 
N 6 HOH 118 518 237 HOH HOH H . 
N 6 HOH 119 519 170 HOH HOH H . 
N 6 HOH 120 520 17  HOH HOH H . 
N 6 HOH 121 521 158 HOH HOH H . 
N 6 HOH 122 522 379 HOH HOH H . 
N 6 HOH 123 523 50  HOH HOH H . 
N 6 HOH 124 524 350 HOH HOH H . 
N 6 HOH 125 525 323 HOH HOH H . 
N 6 HOH 126 526 72  HOH HOH H . 
N 6 HOH 127 527 124 HOH HOH H . 
N 6 HOH 128 528 234 HOH HOH H . 
N 6 HOH 129 529 327 HOH HOH H . 
N 6 HOH 130 530 387 HOH HOH H . 
N 6 HOH 131 531 122 HOH HOH H . 
N 6 HOH 132 532 383 HOH HOH H . 
N 6 HOH 133 533 365 HOH HOH H . 
N 6 HOH 134 534 432 HOH HOH H . 
N 6 HOH 135 535 423 HOH HOH H . 
N 6 HOH 136 536 441 HOH HOH H . 
N 6 HOH 137 537 371 HOH HOH H . 
N 6 HOH 138 538 111 HOH HOH H . 
N 6 HOH 139 539 287 HOH HOH H . 
N 6 HOH 140 540 319 HOH HOH H . 
N 6 HOH 141 541 294 HOH HOH H . 
N 6 HOH 142 542 99  HOH HOH H . 
N 6 HOH 143 543 345 HOH HOH H . 
N 6 HOH 144 544 346 HOH HOH H . 
N 6 HOH 145 545 120 HOH HOH H . 
N 6 HOH 146 546 459 HOH HOH H . 
N 6 HOH 147 547 68  HOH HOH H . 
N 6 HOH 148 548 299 HOH HOH H . 
N 6 HOH 149 549 310 HOH HOH H . 
N 6 HOH 150 550 94  HOH HOH H . 
N 6 HOH 151 551 248 HOH HOH H . 
N 6 HOH 152 552 217 HOH HOH H . 
N 6 HOH 153 553 235 HOH HOH H . 
N 6 HOH 154 554 154 HOH HOH H . 
N 6 HOH 155 555 102 HOH HOH H . 
N 6 HOH 156 556 316 HOH HOH H . 
N 6 HOH 157 557 180 HOH HOH H . 
N 6 HOH 158 558 146 HOH HOH H . 
N 6 HOH 159 559 104 HOH HOH H . 
N 6 HOH 160 560 253 HOH HOH H . 
N 6 HOH 161 561 277 HOH HOH H . 
N 6 HOH 162 562 8   HOH HOH H . 
N 6 HOH 163 563 107 HOH HOH H . 
N 6 HOH 164 564 391 HOH HOH H . 
N 6 HOH 165 565 313 HOH HOH H . 
N 6 HOH 166 566 204 HOH HOH H . 
N 6 HOH 167 567 182 HOH HOH H . 
N 6 HOH 168 568 141 HOH HOH H . 
N 6 HOH 169 569 239 HOH HOH H . 
N 6 HOH 170 570 32  HOH HOH H . 
N 6 HOH 171 571 73  HOH HOH H . 
N 6 HOH 172 572 311 HOH HOH H . 
N 6 HOH 173 573 142 HOH HOH H . 
N 6 HOH 174 574 390 HOH HOH H . 
N 6 HOH 175 575 95  HOH HOH H . 
N 6 HOH 176 576 45  HOH HOH H . 
N 6 HOH 177 577 282 HOH HOH H . 
N 6 HOH 178 578 36  HOH HOH H . 
N 6 HOH 179 579 116 HOH HOH H . 
N 6 HOH 180 580 59  HOH HOH H . 
N 6 HOH 181 581 393 HOH HOH H . 
N 6 HOH 182 582 451 HOH HOH H . 
N 6 HOH 183 583 389 HOH HOH H . 
N 6 HOH 184 584 133 HOH HOH H . 
N 6 HOH 185 585 185 HOH HOH H . 
N 6 HOH 186 586 324 HOH HOH H . 
N 6 HOH 187 587 289 HOH HOH H . 
N 6 HOH 188 588 367 HOH HOH H . 
N 6 HOH 189 589 5   HOH HOH H . 
N 6 HOH 190 590 132 HOH HOH H . 
N 6 HOH 191 591 267 HOH HOH H . 
N 6 HOH 192 592 439 HOH HOH H . 
N 6 HOH 193 593 250 HOH HOH H . 
N 6 HOH 194 594 214 HOH HOH H . 
N 6 HOH 195 595 399 HOH HOH H . 
N 6 HOH 196 596 96  HOH HOH H . 
N 6 HOH 197 597 279 HOH HOH H . 
N 6 HOH 198 598 100 HOH HOH H . 
N 6 HOH 199 599 341 HOH HOH H . 
N 6 HOH 200 600 215 HOH HOH H . 
N 6 HOH 201 601 405 HOH HOH H . 
N 6 HOH 202 602 186 HOH HOH H . 
N 6 HOH 203 603 129 HOH HOH H . 
N 6 HOH 204 604 266 HOH HOH H . 
N 6 HOH 205 605 382 HOH HOH H . 
N 6 HOH 206 606 466 HOH HOH H . 
N 6 HOH 207 607 333 HOH HOH H . 
N 6 HOH 208 608 467 HOH HOH H . 
N 6 HOH 209 609 274 HOH HOH H . 
N 6 HOH 210 610 465 HOH HOH H . 
N 6 HOH 211 611 300 HOH HOH H . 
N 6 HOH 212 612 374 HOH HOH H . 
N 6 HOH 213 613 306 HOH HOH H . 
N 6 HOH 214 614 220 HOH HOH H . 
N 6 HOH 215 615 407 HOH HOH H . 
N 6 HOH 216 616 340 HOH HOH H . 
N 6 HOH 217 617 385 HOH HOH H . 
N 6 HOH 218 618 161 HOH HOH H . 
N 6 HOH 219 619 245 HOH HOH H . 
N 6 HOH 220 620 457 HOH HOH H . 
N 6 HOH 221 621 456 HOH HOH H . 
N 6 HOH 222 622 243 HOH HOH H . 
N 6 HOH 223 623 184 HOH HOH H . 
N 6 HOH 224 624 202 HOH HOH H . 
N 6 HOH 225 625 344 HOH HOH H . 
N 6 HOH 226 626 404 HOH HOH H . 
N 6 HOH 227 627 210 HOH HOH H . 
N 6 HOH 228 628 276 HOH HOH H . 
O 6 HOH 1   401 464 HOH HOH L . 
O 6 HOH 2   402 260 HOH HOH L . 
O 6 HOH 3   403 409 HOH HOH L . 
O 6 HOH 4   404 460 HOH HOH L . 
O 6 HOH 5   405 81  HOH HOH L . 
O 6 HOH 6   406 363 HOH HOH L . 
O 6 HOH 7   407 336 HOH HOH L . 
O 6 HOH 8   408 82  HOH HOH L . 
O 6 HOH 9   409 221 HOH HOH L . 
O 6 HOH 10  410 305 HOH HOH L . 
O 6 HOH 11  411 169 HOH HOH L . 
O 6 HOH 12  412 357 HOH HOH L . 
O 6 HOH 13  413 190 HOH HOH L . 
O 6 HOH 14  414 165 HOH HOH L . 
O 6 HOH 15  415 342 HOH HOH L . 
O 6 HOH 16  416 283 HOH HOH L . 
O 6 HOH 17  417 332 HOH HOH L . 
O 6 HOH 18  418 330 HOH HOH L . 
O 6 HOH 19  419 361 HOH HOH L . 
O 6 HOH 20  420 231 HOH HOH L . 
O 6 HOH 21  421 156 HOH HOH L . 
O 6 HOH 22  422 458 HOH HOH L . 
O 6 HOH 23  423 225 HOH HOH L . 
O 6 HOH 24  424 189 HOH HOH L . 
O 6 HOH 25  425 194 HOH HOH L . 
O 6 HOH 26  426 252 HOH HOH L . 
O 6 HOH 27  427 470 HOH HOH L . 
O 6 HOH 28  428 177 HOH HOH L . 
O 6 HOH 29  429 44  HOH HOH L . 
O 6 HOH 30  430 284 HOH HOH L . 
O 6 HOH 31  431 178 HOH HOH L . 
O 6 HOH 32  432 126 HOH HOH L . 
O 6 HOH 33  433 66  HOH HOH L . 
O 6 HOH 34  434 318 HOH HOH L . 
O 6 HOH 35  435 62  HOH HOH L . 
O 6 HOH 36  436 35  HOH HOH L . 
O 6 HOH 37  437 227 HOH HOH L . 
O 6 HOH 38  438 64  HOH HOH L . 
O 6 HOH 39  439 421 HOH HOH L . 
O 6 HOH 40  440 67  HOH HOH L . 
O 6 HOH 41  441 74  HOH HOH L . 
O 6 HOH 42  442 307 HOH HOH L . 
O 6 HOH 43  443 375 HOH HOH L . 
O 6 HOH 44  444 468 HOH HOH L . 
O 6 HOH 45  445 255 HOH HOH L . 
O 6 HOH 46  446 31  HOH HOH L . 
O 6 HOH 47  447 137 HOH HOH L . 
O 6 HOH 48  448 54  HOH HOH L . 
O 6 HOH 49  449 290 HOH HOH L . 
O 6 HOH 50  450 70  HOH HOH L . 
O 6 HOH 51  451 433 HOH HOH L . 
O 6 HOH 52  452 261 HOH HOH L . 
O 6 HOH 53  453 150 HOH HOH L . 
O 6 HOH 54  454 16  HOH HOH L . 
O 6 HOH 55  455 413 HOH HOH L . 
O 6 HOH 56  456 229 HOH HOH L . 
O 6 HOH 57  457 13  HOH HOH L . 
O 6 HOH 58  458 291 HOH HOH L . 
O 6 HOH 59  459 348 HOH HOH L . 
O 6 HOH 60  460 431 HOH HOH L . 
O 6 HOH 61  461 337 HOH HOH L . 
O 6 HOH 62  462 427 HOH HOH L . 
O 6 HOH 63  463 174 HOH HOH L . 
O 6 HOH 64  464 139 HOH HOH L . 
O 6 HOH 65  465 349 HOH HOH L . 
O 6 HOH 66  466 309 HOH HOH L . 
O 6 HOH 67  467 211 HOH HOH L . 
O 6 HOH 68  468 296 HOH HOH L . 
O 6 HOH 69  469 157 HOH HOH L . 
O 6 HOH 70  470 7   HOH HOH L . 
O 6 HOH 71  471 469 HOH HOH L . 
O 6 HOH 72  472 321 HOH HOH L . 
O 6 HOH 73  473 69  HOH HOH L . 
O 6 HOH 74  474 3   HOH HOH L . 
O 6 HOH 75  475 373 HOH HOH L . 
O 6 HOH 76  476 168 HOH HOH L . 
O 6 HOH 77  477 14  HOH HOH L . 
O 6 HOH 78  478 181 HOH HOH L . 
O 6 HOH 79  479 9   HOH HOH L . 
O 6 HOH 80  480 199 HOH HOH L . 
O 6 HOH 81  481 80  HOH HOH L . 
O 6 HOH 82  482 22  HOH HOH L . 
O 6 HOH 83  483 63  HOH HOH L . 
O 6 HOH 84  484 425 HOH HOH L . 
O 6 HOH 85  485 130 HOH HOH L . 
O 6 HOH 86  486 47  HOH HOH L . 
O 6 HOH 87  487 236 HOH HOH L . 
O 6 HOH 88  488 258 HOH HOH L . 
O 6 HOH 89  489 77  HOH HOH L . 
O 6 HOH 90  490 27  HOH HOH L . 
O 6 HOH 91  491 208 HOH HOH L . 
O 6 HOH 92  492 30  HOH HOH L . 
O 6 HOH 93  493 33  HOH HOH L . 
O 6 HOH 94  494 380 HOH HOH L . 
O 6 HOH 95  495 83  HOH HOH L . 
O 6 HOH 96  496 140 HOH HOH L . 
O 6 HOH 97  497 372 HOH HOH L . 
O 6 HOH 98  498 110 HOH HOH L . 
O 6 HOH 99  499 308 HOH HOH L . 
O 6 HOH 100 500 4   HOH HOH L . 
O 6 HOH 101 501 117 HOH HOH L . 
O 6 HOH 102 502 1   HOH HOH L . 
O 6 HOH 103 503 52  HOH HOH L . 
O 6 HOH 104 504 196 HOH HOH L . 
O 6 HOH 105 505 370 HOH HOH L . 
O 6 HOH 106 506 437 HOH HOH L . 
O 6 HOH 107 507 125 HOH HOH L . 
O 6 HOH 108 508 241 HOH HOH L . 
O 6 HOH 109 509 28  HOH HOH L . 
O 6 HOH 110 510 136 HOH HOH L . 
O 6 HOH 111 511 159 HOH HOH L . 
O 6 HOH 112 512 278 HOH HOH L . 
O 6 HOH 113 513 84  HOH HOH L . 
O 6 HOH 114 514 51  HOH HOH L . 
O 6 HOH 115 515 91  HOH HOH L . 
O 6 HOH 116 516 23  HOH HOH L . 
O 6 HOH 117 517 26  HOH HOH L . 
O 6 HOH 118 518 386 HOH HOH L . 
O 6 HOH 119 519 58  HOH HOH L . 
O 6 HOH 120 520 207 HOH HOH L . 
O 6 HOH 121 521 29  HOH HOH L . 
O 6 HOH 122 522 78  HOH HOH L . 
O 6 HOH 123 523 347 HOH HOH L . 
O 6 HOH 124 524 65  HOH HOH L . 
O 6 HOH 125 525 249 HOH HOH L . 
O 6 HOH 126 526 2   HOH HOH L . 
O 6 HOH 127 527 101 HOH HOH L . 
O 6 HOH 128 528 173 HOH HOH L . 
O 6 HOH 129 529 360 HOH HOH L . 
O 6 HOH 130 530 269 HOH HOH L . 
O 6 HOH 131 531 147 HOH HOH L . 
O 6 HOH 132 532 264 HOH HOH L . 
O 6 HOH 133 533 55  HOH HOH L . 
O 6 HOH 134 534 443 HOH HOH L . 
O 6 HOH 135 535 103 HOH HOH L . 
O 6 HOH 136 536 15  HOH HOH L . 
O 6 HOH 137 537 34  HOH HOH L . 
O 6 HOH 138 538 418 HOH HOH L . 
O 6 HOH 139 539 353 HOH HOH L . 
O 6 HOH 140 540 6   HOH HOH L . 
O 6 HOH 141 541 53  HOH HOH L . 
O 6 HOH 142 542 148 HOH HOH L . 
O 6 HOH 143 543 435 HOH HOH L . 
O 6 HOH 144 544 285 HOH HOH L . 
O 6 HOH 145 545 118 HOH HOH L . 
O 6 HOH 146 546 187 HOH HOH L . 
O 6 HOH 147 547 326 HOH HOH L . 
O 6 HOH 148 548 79  HOH HOH L . 
O 6 HOH 149 549 424 HOH HOH L . 
O 6 HOH 150 550 430 HOH HOH L . 
O 6 HOH 151 551 351 HOH HOH L . 
O 6 HOH 152 552 155 HOH HOH L . 
O 6 HOH 153 553 442 HOH HOH L . 
O 6 HOH 154 554 152 HOH HOH L . 
O 6 HOH 155 555 242 HOH HOH L . 
O 6 HOH 156 556 200 HOH HOH L . 
O 6 HOH 157 557 93  HOH HOH L . 
O 6 HOH 158 558 56  HOH HOH L . 
O 6 HOH 159 559 172 HOH HOH L . 
O 6 HOH 160 560 212 HOH HOH L . 
O 6 HOH 161 561 12  HOH HOH L . 
O 6 HOH 162 562 97  HOH HOH L . 
O 6 HOH 163 563 216 HOH HOH L . 
O 6 HOH 164 564 145 HOH HOH L . 
O 6 HOH 165 565 230 HOH HOH L . 
O 6 HOH 166 566 359 HOH HOH L . 
O 6 HOH 167 567 143 HOH HOH L . 
O 6 HOH 168 568 71  HOH HOH L . 
O 6 HOH 169 569 401 HOH HOH L . 
O 6 HOH 170 570 191 HOH HOH L . 
O 6 HOH 171 571 192 HOH HOH L . 
O 6 HOH 172 572 463 HOH HOH L . 
O 6 HOH 173 573 119 HOH HOH L . 
O 6 HOH 174 574 10  HOH HOH L . 
O 6 HOH 175 575 41  HOH HOH L . 
O 6 HOH 176 576 410 HOH HOH L . 
O 6 HOH 177 577 273 HOH HOH L . 
O 6 HOH 178 578 263 HOH HOH L . 
O 6 HOH 179 579 85  HOH HOH L . 
O 6 HOH 180 580 312 HOH HOH L . 
O 6 HOH 181 581 388 HOH HOH L . 
O 6 HOH 182 582 322 HOH HOH L . 
O 6 HOH 183 583 408 HOH HOH L . 
O 6 HOH 184 584 90  HOH HOH L . 
O 6 HOH 185 585 362 HOH HOH L . 
O 6 HOH 186 586 398 HOH HOH L . 
O 6 HOH 187 587 338 HOH HOH L . 
O 6 HOH 188 588 39  HOH HOH L . 
O 6 HOH 189 589 394 HOH HOH L . 
O 6 HOH 190 590 396 HOH HOH L . 
O 6 HOH 191 591 368 HOH HOH L . 
O 6 HOH 192 592 24  HOH HOH L . 
O 6 HOH 193 593 402 HOH HOH L . 
O 6 HOH 194 594 352 HOH HOH L . 
O 6 HOH 195 595 272 HOH HOH L . 
O 6 HOH 196 596 201 HOH HOH L . 
O 6 HOH 197 597 444 HOH HOH L . 
O 6 HOH 198 598 395 HOH HOH L . 
O 6 HOH 199 599 461 HOH HOH L . 
O 6 HOH 200 600 426 HOH HOH L . 
O 6 HOH 201 601 428 HOH HOH L . 
O 6 HOH 202 602 335 HOH HOH L . 
O 6 HOH 203 603 288 HOH HOH L . 
O 6 HOH 204 604 175 HOH HOH L . 
O 6 HOH 205 605 448 HOH HOH L . 
O 6 HOH 206 606 275 HOH HOH L . 
O 6 HOH 207 607 331 HOH HOH L . 
O 6 HOH 208 608 446 HOH HOH L . 
O 6 HOH 209 609 262 HOH HOH L . 
O 6 HOH 210 610 244 HOH HOH L . 
O 6 HOH 211 611 366 HOH HOH L . 
O 6 HOH 212 612 114 HOH HOH L . 
O 6 HOH 213 613 219 HOH HOH L . 
O 6 HOH 214 614 297 HOH HOH L . 
O 6 HOH 215 615 195 HOH HOH L . 
O 6 HOH 216 616 265 HOH HOH L . 
O 6 HOH 217 617 445 HOH HOH L . 
O 6 HOH 218 618 447 HOH HOH L . 
O 6 HOH 219 619 226 HOH HOH L . 
O 6 HOH 220 620 471 HOH HOH L . 
O 6 HOH 221 621 92  HOH HOH L . 
O 6 HOH 222 622 232 HOH HOH L . 
O 6 HOH 223 623 384 HOH HOH L . 
O 6 HOH 224 624 108 HOH HOH L . 
O 6 HOH 225 625 403 HOH HOH L . 
O 6 HOH 226 626 247 HOH HOH L . 
O 6 HOH 227 627 87  HOH HOH L . 
O 6 HOH 228 628 450 HOH HOH L . 
O 6 HOH 229 629 377 HOH HOH L . 
O 6 HOH 230 630 400 HOH HOH L . 
O 6 HOH 231 631 270 HOH HOH L . 
O 6 HOH 232 632 75  HOH HOH L . 
O 6 HOH 233 633 113 HOH HOH L . 
O 6 HOH 234 634 160 HOH HOH L . 
O 6 HOH 235 635 449 HOH HOH L . 
O 6 HOH 236 636 436 HOH HOH L . 
O 6 HOH 237 637 222 HOH HOH L . 
O 6 HOH 238 638 206 HOH HOH L . 
O 6 HOH 239 639 138 HOH HOH L . 
O 6 HOH 240 640 203 HOH HOH L . 
O 6 HOH 241 641 151 HOH HOH L . 
O 6 HOH 242 642 406 HOH HOH L . 
O 6 HOH 243 643 397 HOH HOH L . 
O 6 HOH 244 644 440 HOH HOH L . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0405 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8TN7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     91.095 
_cell.length_a_esd                 ? 
_cell.length_b                     91.095 
_cell.length_b_esd                 ? 
_cell.length_c                     202.254 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8TN7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                179 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 65 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8TN7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.58 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          52.40 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2.4M Ammonium Sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 22-ID' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   22-ID 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8TN7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.56 
_reflns.d_resolution_low                               62.28 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     70955 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                14.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.56 
_reflns_shell.d_res_low                                     1.59 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4697 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.479 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.37 
_refine.aniso_B[1][2]                            0.19 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            0.37 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -1.20 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.843 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.971 
_refine.correlation_coeff_Fo_to_Fc_free          0.960 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8TN7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.56 
_refine.ls_d_res_low                             62.28 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     66996 
_refine.ls_number_reflns_R_free                  3712 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.25 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.17148 
_refine.ls_R_factor_R_free                       0.19939 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.16991 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'FOURIER SYNTHESIS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.074 
_refine.pdbx_overall_ESU_R_Free                  0.076 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             1.589 
_refine.overall_SU_ML                            0.055 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.56 
_refine_hist.d_res_low                        62.28 
_refine_hist.number_atoms_solvent             472 
_refine_hist.number_atoms_total               3839 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3298 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         69 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.012  3490 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  3138 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.738  1.647  4767 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.598  1.566  7293 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.390  5.000  446  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 5.482  5.000  17   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.098 10.000 549  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.086  0.200  544  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.010  0.020  4034 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  778  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.229  2.214  1755 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.208  2.214  1755 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 3.035  3.971  2194 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 3.035  3.973  2195 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 3.555  2.552  1735 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.405  2.521  1700 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.036  4.464  2514 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 6.599  24.83  3914 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 6.380  22.35  3778 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.560 
_refine_ls_shell.d_res_low                        1.601 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             263 
_refine_ls_shell.number_reflns_R_work             4697 
_refine_ls_shell.percent_reflns_obs               95.77 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.300 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.296 
# 
_struct.entry_id                     8TN7 
_struct.title                        
'The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a disaccharide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8TN7 
_struct_keywords.text            'monoclonal antibody, TG10, GlcNac-GlcNac, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 4 ? 
N N N 6 ? 
O N N 6 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8TN7 8TN7 ? 1 ? 1 
2 PDB 8TN7 8TN7 ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8TN7 H 1 ? 220 ? 8TN7 1 ? 230 ? 1 230 
2 2 8TN7 L 1 ? 214 ? 8TN7 1 ? 233 ? 1 233 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5930  ? 
1 MORE         -125  ? 
1 'SSA (A^2)'  18790 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 28  ? TYR A 32  ? PRO H 29  TYR H 37  5 ? 5 
HELX_P HELX_P2  AA2 ASP A 62  ? LYS A 65  ? ASP H 69  LYS H 72  5 ? 4 
HELX_P HELX_P3  AA3 ASN A 74  ? LYS A 76  ? ASN H 82  LYS H 84  5 ? 3 
HELX_P HELX_P4  AA4 ARG A 87  ? THR A 91  ? ARG H 95  THR H 99  5 ? 5 
HELX_P HELX_P5  AA5 PRO A 100 ? GLY A 103 ? PRO H 108 GLY H 113 5 ? 4 
HELX_P HELX_P6  AA6 SER A 132 ? LYS A 134 ? SER H 142 LYS H 144 5 ? 3 
HELX_P HELX_P7  AA7 SER A 161 ? ALA A 163 ? SER H 171 ALA H 173 5 ? 3 
HELX_P HELX_P8  AA8 SER A 192 ? LEU A 194 ? SER H 202 LEU H 204 5 ? 3 
HELX_P HELX_P9  AA9 LYS A 206 ? ASN A 209 ? LYS H 216 ASN H 219 5 ? 4 
HELX_P HELX_P10 AB1 SER B 30  ? SER B 32  ? SER L 30  SER L 37  5 ? 3 
HELX_P HELX_P11 AB2 GLU B 80  ? PHE B 84  ? GLU L 95  PHE L 99  5 ? 5 
HELX_P HELX_P12 AB3 SER B 122 ? SER B 128 ? SER L 141 SER L 147 1 ? 7 
HELX_P HELX_P13 AB4 LYS B 184 ? GLU B 188 ? LYS L 203 GLU L 207 1 ? 5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 22  SG ? ? ? 1_555 A CYS 96  SG B ? H CYS 23  H CYS 104 1_555 ? ? ? ? ? ? ? 2.024 ? ? 
disulf2 disulf ?    ? A CYS 22  SG ? ? ? 1_555 A CYS 96  SG A ? H CYS 23  H CYS 104 1_555 ? ? ? ? ? ? ? 2.313 ? ? 
disulf3 disulf ?    ? A CYS 145 SG ? ? ? 1_555 A CYS 201 SG ? ? H CYS 155 H CYS 211 1_555 ? ? ? ? ? ? ? 2.017 ? ? 
disulf4 disulf ?    ? B CYS 23  SG ? ? ? 1_555 B CYS 89  SG ? ? L CYS 23  L CYS 104 1_555 ? ? ? ? ? ? ? 2.145 ? ? 
disulf5 disulf ?    ? B CYS 135 SG ? ? ? 1_555 B CYS 195 SG A ? L CYS 154 L CYS 214 1_555 ? ? ? ? ? ? ? 1.924 ? ? 
disulf6 disulf ?    ? B CYS 135 SG ? ? ? 1_555 B CYS 195 SG B ? L CYS 154 L CYS 214 1_555 ? ? ? ? ? ? ? 2.179 ? ? 
covale1 covale both ? C GCS .   O6 ? ? ? 1_555 C GCS .   C1 ? ? A GCS 1   A GCS 2   1_555 ? ? ? ? ? ? ? 1.475 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 22  ? CYS A 96  B CYS H 23  ? 1_555 CYS H 104 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 22  ? CYS A 96  A CYS H 23  ? 1_555 CYS H 104 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 145 ? CYS A 201 ? CYS H 155 ? 1_555 CYS H 211 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 23  ? CYS B 89  ? CYS L 23  ? 1_555 CYS L 104 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS B 135 ? CYS B 195 A CYS L 154 ? 1_555 CYS L 214 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS B 135 ? CYS B 195 B CYS L 154 ? 1_555 CYS L 214 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 151 A . ? PHE 161 H PRO 152 A ? PRO 162 H 1 -11.03 
2 GLU 153 A . ? GLU 163 H PRO 154 A ? PRO 164 H 1 -8.41  
3 SER 7   B . ? SER 7   L PRO 8   B ? PRO 8   L 1 -10.77 
4 SER 7   B . ? SER 7   L PRO 8   B ? PRO 8   L 1 -6.63  
5 SER 7   B . ? SER 7   L PRO 8   B ? PRO 8   L 1 -11.08 
6 ALA 95  B . ? ALA 114 L PRO 96  B ? PRO 115 L 1 -3.51  
7 TYR 141 B . ? TYR 160 L PRO 142 B ? PRO 161 L 1 6.67   
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 3 ? 
AA7 ? 6 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA7 5 6 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 3   ? SER A 7   ? GLN H 3   SER H 7   
AA1 2 LEU A 18  ? SER A 25  ? LEU H 19  SER H 26  
AA1 3 SER A 78  ? MET A 83  ? SER H 86  MET H 91  
AA1 4 PHE A 68  ? ASP A 73  ? PHE H 76  ASP H 81  
AA2 1 GLY A 10  ? VAL A 12  ? GLY H 11  VAL H 13  
AA2 2 THR A 112 ? VAL A 116 ? THR H 122 VAL H 126 
AA2 3 ALA A 92  ? THR A 98  ? ALA H 100 THR H 106 
AA2 4 MET A 34  ? GLN A 39  ? MET H 39  GLN H 44  
AA2 5 GLU A 46  ? ILE A 51  ? GLU H 51  ILE H 56  
AA2 6 LYS A 58  ? TYR A 60  ? LYS H 65  TYR H 67  
AA3 1 SER A 125 ? LEU A 129 ? SER H 135 LEU H 139 
AA3 2 THR A 140 ? TYR A 150 ? THR H 150 TYR H 160 
AA3 3 TYR A 181 ? PRO A 190 ? TYR H 191 PRO H 200 
AA3 4 VAL A 168 ? THR A 170 ? VAL H 178 THR H 180 
AA4 1 THR A 136 ? SER A 137 ? THR H 146 SER H 147 
AA4 2 THR A 140 ? TYR A 150 ? THR H 150 TYR H 160 
AA4 3 TYR A 181 ? PRO A 190 ? TYR H 191 PRO H 200 
AA4 4 VAL A 174 ? LEU A 175 ? VAL H 184 LEU H 185 
AA5 1 THR A 156 ? TRP A 159 ? THR H 166 TRP H 169 
AA5 2 ILE A 200 ? HIS A 205 ? ILE H 210 HIS H 215 
AA5 3 THR A 210 ? LYS A 215 ? THR H 220 LYS H 225 
AA6 1 LEU B 4   ? SER B 7   ? LEU L 4   SER L 7   
AA6 2 ALA B 19  ? VAL B 29  ? ALA L 19  VAL L 29  
AA6 3 PHE B 63  ? ILE B 76  ? PHE L 76  ILE L 91  
AA7 1 THR B 10  ? LEU B 13  ? THR L 10  LEU L 13  
AA7 2 THR B 103 ? ILE B 107 ? THR L 122 ILE L 126 
AA7 3 ALA B 85  ? GLN B 91  ? ALA L 100 GLN L 106 
AA7 4 LEU B 34  ? GLN B 39  ? LEU L 39  GLN L 44  
AA7 5 ARG B 46  ? TYR B 50  ? ARG L 51  TYR L 55  
AA7 6 ASN B 54  ? ARG B 55  ? ASN L 66  ARG L 67  
AA8 1 SER B 115 ? PHE B 119 ? SER L 134 PHE L 138 
AA8 2 THR B 130 ? PHE B 140 ? THR L 149 PHE L 159 
AA8 3 TYR B 174 ? SER B 183 ? TYR L 193 SER L 202 
AA8 4 SER B 160 ? VAL B 164 ? SER L 179 VAL L 183 
AA9 1 ALA B 154 ? LEU B 155 ? ALA L 173 LEU L 174 
AA9 2 LYS B 146 ? VAL B 151 ? LYS L 165 VAL L 170 
AA9 3 VAL B 192 ? THR B 198 ? VAL L 211 THR L 217 
AA9 4 VAL B 206 ? ASN B 211 ? VAL L 225 ASN L 230 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N SER A 7   ? N SER H 7   O SER A 21  ? O SER H 22  
AA1 2 3 N LEU A 20  ? N LEU H 21  O LEU A 81  ? O LEU H 89  
AA1 3 4 O SER A 78  ? O SER H 86  N ASP A 73  ? N ASP H 81  
AA2 1 2 N VAL A 12  ? N VAL H 13  O THR A 115 ? O THR H 125 
AA2 2 3 O VAL A 114 ? O VAL H 124 N ALA A 92  ? N ALA H 100 
AA2 3 4 O TYR A 95  ? O TYR H 103 N VAL A 37  ? N VAL H 42  
AA2 4 5 N ARG A 38  ? N ARG H 43  O GLU A 46  ? O GLU H 51  
AA2 5 6 N ASN A 50  ? N ASN H 55  O TYR A 59  ? O TYR H 66  
AA3 1 2 N PHE A 127 ? N PHE H 137 O LEU A 146 ? O LEU H 156 
AA3 2 3 N VAL A 147 ? N VAL H 157 O LEU A 183 ? O LEU H 193 
AA3 3 4 O VAL A 186 ? O VAL H 196 N HIS A 169 ? N HIS H 179 
AA4 1 2 N SER A 137 ? N SER H 147 O THR A 140 ? O THR H 150 
AA4 2 3 N VAL A 147 ? N VAL H 157 O LEU A 183 ? O LEU H 193 
AA4 3 4 O SER A 182 ? O SER H 192 N VAL A 174 ? N VAL H 184 
AA5 1 2 N SER A 158 ? N SER H 168 O ASN A 202 ? O ASN H 212 
AA5 2 3 N VAL A 203 ? N VAL H 213 O VAL A 212 ? O VAL H 222 
AA6 1 2 N THR B 5   ? N THR L 5   O ARG B 24  ? O ARG L 24  
AA6 2 3 N CYS B 23  ? N CYS L 23  O PHE B 72  ? O PHE L 87  
AA7 1 2 N LEU B 11  ? N LEU L 11  O GLU B 106 ? O GLU L 125 
AA7 2 3 O LEU B 105 ? O LEU L 124 N ALA B 85  ? N ALA L 100 
AA7 3 4 O GLN B 90  ? O GLN L 105 N ALA B 35  ? N ALA L 40  
AA7 4 5 N TRP B 36  ? N TRP L 41  O PHE B 48  ? O PHE L 53  
AA7 5 6 N TYR B 50  ? N TYR L 55  O ASN B 54  ? O ASN L 66  
AA8 1 2 N SER B 115 ? N SER L 134 O ASN B 138 ? O ASN L 157 
AA8 2 3 N LEU B 137 ? N LEU L 156 O LEU B 176 ? O LEU L 195 
AA8 3 4 O THR B 179 ? O THR L 198 N GLN B 161 ? N GLN L 180 
AA9 1 2 O ALA B 154 ? O ALA L 173 N VAL B 151 ? N VAL L 170 
AA9 2 3 N GLN B 148 ? N GLN L 167 O GLU B 196 ? O GLU L 215 
AA9 3 4 N CYS B 195 ? N CYS L 214 O LYS B 208 ? O LYS L 227 
# 
_pdbx_entry_details.entry_id                   8TN7 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O2 H SO4 304 ? ? O H HOH 403 ? ? 2.08 
2 1 O  H HOH 448 ? ? O H HOH 573 ? ? 2.16 
3 1 O  L ILE 137 ? ? O L HOH 401 ? ? 2.16 
4 1 O  L HOH 583 ? ? O L HOH 636 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    H 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     591 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    L 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     532 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   6_554 
_pdbx_validate_symm_contact.dist              2.12 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA H 100 ? ? 179.27 164.28 
2 1 ASP H 116 ? ? -98.13 44.18  
3 1 ASP H 159 ? ? 65.02  64.19  
4 1 ALA L 57  ? ? 71.85  -38.72 
5 1 ALA L 100 ? ? 176.99 172.58 
6 1 ASN L 158 ? ? 57.43  75.07  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 H SO4 303 ? F SO4 . 
2 1 L SO4 304 ? L SO4 . 
3 1 H HOH 404 ? N HOH . 
4 1 H HOH 547 ? N HOH . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GCS C1   C  N R 89  
GCS C2   C  N R 90  
GCS C3   C  N R 91  
GCS C4   C  N S 92  
GCS C5   C  N R 93  
GCS C6   C  N N 94  
GCS N2   N  N N 95  
GCS O1   O  N N 96  
GCS O3   O  N N 97  
GCS O4   O  N N 98  
GCS O5   O  N N 99  
GCS O6   O  N N 100 
GCS H1   H  N N 101 
GCS H2   H  N N 102 
GCS H3   H  N N 103 
GCS H4   H  N N 104 
GCS H5   H  N N 105 
GCS H61  H  N N 106 
GCS H62  H  N N 107 
GCS HN21 H  N N 108 
GCS HN22 H  N N 109 
GCS HO1  H  N N 110 
GCS HO3  H  N N 111 
GCS HO4  H  N N 112 
GCS HO6  H  N N 113 
GLN N    N  N N 114 
GLN CA   C  N S 115 
GLN C    C  N N 116 
GLN O    O  N N 117 
GLN CB   C  N N 118 
GLN CG   C  N N 119 
GLN CD   C  N N 120 
GLN OE1  O  N N 121 
GLN NE2  N  N N 122 
GLN OXT  O  N N 123 
GLN H    H  N N 124 
GLN H2   H  N N 125 
GLN HA   H  N N 126 
GLN HB2  H  N N 127 
GLN HB3  H  N N 128 
GLN HG2  H  N N 129 
GLN HG3  H  N N 130 
GLN HE21 H  N N 131 
GLN HE22 H  N N 132 
GLN HXT  H  N N 133 
GLU N    N  N N 134 
GLU CA   C  N S 135 
GLU C    C  N N 136 
GLU O    O  N N 137 
GLU CB   C  N N 138 
GLU CG   C  N N 139 
GLU CD   C  N N 140 
GLU OE1  O  N N 141 
GLU OE2  O  N N 142 
GLU OXT  O  N N 143 
GLU H    H  N N 144 
GLU H2   H  N N 145 
GLU HA   H  N N 146 
GLU HB2  H  N N 147 
GLU HB3  H  N N 148 
GLU HG2  H  N N 149 
GLU HG3  H  N N 150 
GLU HE2  H  N N 151 
GLU HXT  H  N N 152 
GLY N    N  N N 153 
GLY CA   C  N N 154 
GLY C    C  N N 155 
GLY O    O  N N 156 
GLY OXT  O  N N 157 
GLY H    H  N N 158 
GLY H2   H  N N 159 
GLY HA2  H  N N 160 
GLY HA3  H  N N 161 
GLY HXT  H  N N 162 
HIS N    N  N N 163 
HIS CA   C  N S 164 
HIS C    C  N N 165 
HIS O    O  N N 166 
HIS CB   C  N N 167 
HIS CG   C  Y N 168 
HIS ND1  N  Y N 169 
HIS CD2  C  Y N 170 
HIS CE1  C  Y N 171 
HIS NE2  N  Y N 172 
HIS OXT  O  N N 173 
HIS H    H  N N 174 
HIS H2   H  N N 175 
HIS HA   H  N N 176 
HIS HB2  H  N N 177 
HIS HB3  H  N N 178 
HIS HD1  H  N N 179 
HIS HD2  H  N N 180 
HIS HE1  H  N N 181 
HIS HE2  H  N N 182 
HIS HXT  H  N N 183 
HOH O    O  N N 184 
HOH H1   H  N N 185 
HOH H2   H  N N 186 
ILE N    N  N N 187 
ILE CA   C  N S 188 
ILE C    C  N N 189 
ILE O    O  N N 190 
ILE CB   C  N S 191 
ILE CG1  C  N N 192 
ILE CG2  C  N N 193 
ILE CD1  C  N N 194 
ILE OXT  O  N N 195 
ILE H    H  N N 196 
ILE H2   H  N N 197 
ILE HA   H  N N 198 
ILE HB   H  N N 199 
ILE HG12 H  N N 200 
ILE HG13 H  N N 201 
ILE HG21 H  N N 202 
ILE HG22 H  N N 203 
ILE HG23 H  N N 204 
ILE HD11 H  N N 205 
ILE HD12 H  N N 206 
ILE HD13 H  N N 207 
ILE HXT  H  N N 208 
LEU N    N  N N 209 
LEU CA   C  N S 210 
LEU C    C  N N 211 
LEU O    O  N N 212 
LEU CB   C  N N 213 
LEU CG   C  N N 214 
LEU CD1  C  N N 215 
LEU CD2  C  N N 216 
LEU OXT  O  N N 217 
LEU H    H  N N 218 
LEU H2   H  N N 219 
LEU HA   H  N N 220 
LEU HB2  H  N N 221 
LEU HB3  H  N N 222 
LEU HG   H  N N 223 
LEU HD11 H  N N 224 
LEU HD12 H  N N 225 
LEU HD13 H  N N 226 
LEU HD21 H  N N 227 
LEU HD22 H  N N 228 
LEU HD23 H  N N 229 
LEU HXT  H  N N 230 
LYS N    N  N N 231 
LYS CA   C  N S 232 
LYS C    C  N N 233 
LYS O    O  N N 234 
LYS CB   C  N N 235 
LYS CG   C  N N 236 
LYS CD   C  N N 237 
LYS CE   C  N N 238 
LYS NZ   N  N N 239 
LYS OXT  O  N N 240 
LYS H    H  N N 241 
LYS H2   H  N N 242 
LYS HA   H  N N 243 
LYS HB2  H  N N 244 
LYS HB3  H  N N 245 
LYS HG2  H  N N 246 
LYS HG3  H  N N 247 
LYS HD2  H  N N 248 
LYS HD3  H  N N 249 
LYS HE2  H  N N 250 
LYS HE3  H  N N 251 
LYS HZ1  H  N N 252 
LYS HZ2  H  N N 253 
LYS HZ3  H  N N 254 
LYS HXT  H  N N 255 
MET N    N  N N 256 
MET CA   C  N S 257 
MET C    C  N N 258 
MET O    O  N N 259 
MET CB   C  N N 260 
MET CG   C  N N 261 
MET SD   S  N N 262 
MET CE   C  N N 263 
MET OXT  O  N N 264 
MET H    H  N N 265 
MET H2   H  N N 266 
MET HA   H  N N 267 
MET HB2  H  N N 268 
MET HB3  H  N N 269 
MET HG2  H  N N 270 
MET HG3  H  N N 271 
MET HE1  H  N N 272 
MET HE2  H  N N 273 
MET HE3  H  N N 274 
MET HXT  H  N N 275 
PHE N    N  N N 276 
PHE CA   C  N S 277 
PHE C    C  N N 278 
PHE O    O  N N 279 
PHE CB   C  N N 280 
PHE CG   C  Y N 281 
PHE CD1  C  Y N 282 
PHE CD2  C  Y N 283 
PHE CE1  C  Y N 284 
PHE CE2  C  Y N 285 
PHE CZ   C  Y N 286 
PHE OXT  O  N N 287 
PHE H    H  N N 288 
PHE H2   H  N N 289 
PHE HA   H  N N 290 
PHE HB2  H  N N 291 
PHE HB3  H  N N 292 
PHE HD1  H  N N 293 
PHE HD2  H  N N 294 
PHE HE1  H  N N 295 
PHE HE2  H  N N 296 
PHE HZ   H  N N 297 
PHE HXT  H  N N 298 
PRO N    N  N N 299 
PRO CA   C  N S 300 
PRO C    C  N N 301 
PRO O    O  N N 302 
PRO CB   C  N N 303 
PRO CG   C  N N 304 
PRO CD   C  N N 305 
PRO OXT  O  N N 306 
PRO H    H  N N 307 
PRO HA   H  N N 308 
PRO HB2  H  N N 309 
PRO HB3  H  N N 310 
PRO HG2  H  N N 311 
PRO HG3  H  N N 312 
PRO HD2  H  N N 313 
PRO HD3  H  N N 314 
PRO HXT  H  N N 315 
SER N    N  N N 316 
SER CA   C  N S 317 
SER C    C  N N 318 
SER O    O  N N 319 
SER CB   C  N N 320 
SER OG   O  N N 321 
SER OXT  O  N N 322 
SER H    H  N N 323 
SER H2   H  N N 324 
SER HA   H  N N 325 
SER HB2  H  N N 326 
SER HB3  H  N N 327 
SER HG   H  N N 328 
SER HXT  H  N N 329 
SO4 S    S  N N 330 
SO4 O1   O  N N 331 
SO4 O2   O  N N 332 
SO4 O3   O  N N 333 
SO4 O4   O  N N 334 
THR N    N  N N 335 
THR CA   C  N S 336 
THR C    C  N N 337 
THR O    O  N N 338 
THR CB   C  N R 339 
THR OG1  O  N N 340 
THR CG2  C  N N 341 
THR OXT  O  N N 342 
THR H    H  N N 343 
THR H2   H  N N 344 
THR HA   H  N N 345 
THR HB   H  N N 346 
THR HG1  H  N N 347 
THR HG21 H  N N 348 
THR HG22 H  N N 349 
THR HG23 H  N N 350 
THR HXT  H  N N 351 
TRP N    N  N N 352 
TRP CA   C  N S 353 
TRP C    C  N N 354 
TRP O    O  N N 355 
TRP CB   C  N N 356 
TRP CG   C  Y N 357 
TRP CD1  C  Y N 358 
TRP CD2  C  Y N 359 
TRP NE1  N  Y N 360 
TRP CE2  C  Y N 361 
TRP CE3  C  Y N 362 
TRP CZ2  C  Y N 363 
TRP CZ3  C  Y N 364 
TRP CH2  C  Y N 365 
TRP OXT  O  N N 366 
TRP H    H  N N 367 
TRP H2   H  N N 368 
TRP HA   H  N N 369 
TRP HB2  H  N N 370 
TRP HB3  H  N N 371 
TRP HD1  H  N N 372 
TRP HE1  H  N N 373 
TRP HE3  H  N N 374 
TRP HZ2  H  N N 375 
TRP HZ3  H  N N 376 
TRP HH2  H  N N 377 
TRP HXT  H  N N 378 
TYR N    N  N N 379 
TYR CA   C  N S 380 
TYR C    C  N N 381 
TYR O    O  N N 382 
TYR CB   C  N N 383 
TYR CG   C  Y N 384 
TYR CD1  C  Y N 385 
TYR CD2  C  Y N 386 
TYR CE1  C  Y N 387 
TYR CE2  C  Y N 388 
TYR CZ   C  Y N 389 
TYR OH   O  N N 390 
TYR OXT  O  N N 391 
TYR H    H  N N 392 
TYR H2   H  N N 393 
TYR HA   H  N N 394 
TYR HB2  H  N N 395 
TYR HB3  H  N N 396 
TYR HD1  H  N N 397 
TYR HD2  H  N N 398 
TYR HE1  H  N N 399 
TYR HE2  H  N N 400 
TYR HH   H  N N 401 
TYR HXT  H  N N 402 
VAL N    N  N N 403 
VAL CA   C  N S 404 
VAL C    C  N N 405 
VAL O    O  N N 406 
VAL CB   C  N N 407 
VAL CG1  C  N N 408 
VAL CG2  C  N N 409 
VAL OXT  O  N N 410 
VAL H    H  N N 411 
VAL H2   H  N N 412 
VAL HA   H  N N 413 
VAL HB   H  N N 414 
VAL HG11 H  N N 415 
VAL HG12 H  N N 416 
VAL HG13 H  N N 417 
VAL HG21 H  N N 418 
VAL HG22 H  N N 419 
VAL HG23 H  N N 420 
VAL HXT  H  N N 421 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GCS C1  C2   sing N N 83  
GCS C1  O1   sing N N 84  
GCS C1  O5   sing N N 85  
GCS C1  H1   sing N N 86  
GCS C2  C3   sing N N 87  
GCS C2  N2   sing N N 88  
GCS C2  H2   sing N N 89  
GCS C3  C4   sing N N 90  
GCS C3  O3   sing N N 91  
GCS C3  H3   sing N N 92  
GCS C4  C5   sing N N 93  
GCS C4  O4   sing N N 94  
GCS C4  H4   sing N N 95  
GCS C5  C6   sing N N 96  
GCS C5  O5   sing N N 97  
GCS C5  H5   sing N N 98  
GCS C6  O6   sing N N 99  
GCS C6  H61  sing N N 100 
GCS C6  H62  sing N N 101 
GCS N2  HN21 sing N N 102 
GCS N2  HN22 sing N N 103 
GCS O1  HO1  sing N N 104 
GCS O3  HO3  sing N N 105 
GCS O4  HO4  sing N N 106 
GCS O6  HO6  sing N N 107 
GLN N   CA   sing N N 108 
GLN N   H    sing N N 109 
GLN N   H2   sing N N 110 
GLN CA  C    sing N N 111 
GLN CA  CB   sing N N 112 
GLN CA  HA   sing N N 113 
GLN C   O    doub N N 114 
GLN C   OXT  sing N N 115 
GLN CB  CG   sing N N 116 
GLN CB  HB2  sing N N 117 
GLN CB  HB3  sing N N 118 
GLN CG  CD   sing N N 119 
GLN CG  HG2  sing N N 120 
GLN CG  HG3  sing N N 121 
GLN CD  OE1  doub N N 122 
GLN CD  NE2  sing N N 123 
GLN NE2 HE21 sing N N 124 
GLN NE2 HE22 sing N N 125 
GLN OXT HXT  sing N N 126 
GLU N   CA   sing N N 127 
GLU N   H    sing N N 128 
GLU N   H2   sing N N 129 
GLU CA  C    sing N N 130 
GLU CA  CB   sing N N 131 
GLU CA  HA   sing N N 132 
GLU C   O    doub N N 133 
GLU C   OXT  sing N N 134 
GLU CB  CG   sing N N 135 
GLU CB  HB2  sing N N 136 
GLU CB  HB3  sing N N 137 
GLU CG  CD   sing N N 138 
GLU CG  HG2  sing N N 139 
GLU CG  HG3  sing N N 140 
GLU CD  OE1  doub N N 141 
GLU CD  OE2  sing N N 142 
GLU OE2 HE2  sing N N 143 
GLU OXT HXT  sing N N 144 
GLY N   CA   sing N N 145 
GLY N   H    sing N N 146 
GLY N   H2   sing N N 147 
GLY CA  C    sing N N 148 
GLY CA  HA2  sing N N 149 
GLY CA  HA3  sing N N 150 
GLY C   O    doub N N 151 
GLY C   OXT  sing N N 152 
GLY OXT HXT  sing N N 153 
HIS N   CA   sing N N 154 
HIS N   H    sing N N 155 
HIS N   H2   sing N N 156 
HIS CA  C    sing N N 157 
HIS CA  CB   sing N N 158 
HIS CA  HA   sing N N 159 
HIS C   O    doub N N 160 
HIS C   OXT  sing N N 161 
HIS CB  CG   sing N N 162 
HIS CB  HB2  sing N N 163 
HIS CB  HB3  sing N N 164 
HIS CG  ND1  sing Y N 165 
HIS CG  CD2  doub Y N 166 
HIS ND1 CE1  doub Y N 167 
HIS ND1 HD1  sing N N 168 
HIS CD2 NE2  sing Y N 169 
HIS CD2 HD2  sing N N 170 
HIS CE1 NE2  sing Y N 171 
HIS CE1 HE1  sing N N 172 
HIS NE2 HE2  sing N N 173 
HIS OXT HXT  sing N N 174 
HOH O   H1   sing N N 175 
HOH O   H2   sing N N 176 
ILE N   CA   sing N N 177 
ILE N   H    sing N N 178 
ILE N   H2   sing N N 179 
ILE CA  C    sing N N 180 
ILE CA  CB   sing N N 181 
ILE CA  HA   sing N N 182 
ILE C   O    doub N N 183 
ILE C   OXT  sing N N 184 
ILE CB  CG1  sing N N 185 
ILE CB  CG2  sing N N 186 
ILE CB  HB   sing N N 187 
ILE CG1 CD1  sing N N 188 
ILE CG1 HG12 sing N N 189 
ILE CG1 HG13 sing N N 190 
ILE CG2 HG21 sing N N 191 
ILE CG2 HG22 sing N N 192 
ILE CG2 HG23 sing N N 193 
ILE CD1 HD11 sing N N 194 
ILE CD1 HD12 sing N N 195 
ILE CD1 HD13 sing N N 196 
ILE OXT HXT  sing N N 197 
LEU N   CA   sing N N 198 
LEU N   H    sing N N 199 
LEU N   H2   sing N N 200 
LEU CA  C    sing N N 201 
LEU CA  CB   sing N N 202 
LEU CA  HA   sing N N 203 
LEU C   O    doub N N 204 
LEU C   OXT  sing N N 205 
LEU CB  CG   sing N N 206 
LEU CB  HB2  sing N N 207 
LEU CB  HB3  sing N N 208 
LEU CG  CD1  sing N N 209 
LEU CG  CD2  sing N N 210 
LEU CG  HG   sing N N 211 
LEU CD1 HD11 sing N N 212 
LEU CD1 HD12 sing N N 213 
LEU CD1 HD13 sing N N 214 
LEU CD2 HD21 sing N N 215 
LEU CD2 HD22 sing N N 216 
LEU CD2 HD23 sing N N 217 
LEU OXT HXT  sing N N 218 
LYS N   CA   sing N N 219 
LYS N   H    sing N N 220 
LYS N   H2   sing N N 221 
LYS CA  C    sing N N 222 
LYS CA  CB   sing N N 223 
LYS CA  HA   sing N N 224 
LYS C   O    doub N N 225 
LYS C   OXT  sing N N 226 
LYS CB  CG   sing N N 227 
LYS CB  HB2  sing N N 228 
LYS CB  HB3  sing N N 229 
LYS CG  CD   sing N N 230 
LYS CG  HG2  sing N N 231 
LYS CG  HG3  sing N N 232 
LYS CD  CE   sing N N 233 
LYS CD  HD2  sing N N 234 
LYS CD  HD3  sing N N 235 
LYS CE  NZ   sing N N 236 
LYS CE  HE2  sing N N 237 
LYS CE  HE3  sing N N 238 
LYS NZ  HZ1  sing N N 239 
LYS NZ  HZ2  sing N N 240 
LYS NZ  HZ3  sing N N 241 
LYS OXT HXT  sing N N 242 
MET N   CA   sing N N 243 
MET N   H    sing N N 244 
MET N   H2   sing N N 245 
MET CA  C    sing N N 246 
MET CA  CB   sing N N 247 
MET CA  HA   sing N N 248 
MET C   O    doub N N 249 
MET C   OXT  sing N N 250 
MET CB  CG   sing N N 251 
MET CB  HB2  sing N N 252 
MET CB  HB3  sing N N 253 
MET CG  SD   sing N N 254 
MET CG  HG2  sing N N 255 
MET CG  HG3  sing N N 256 
MET SD  CE   sing N N 257 
MET CE  HE1  sing N N 258 
MET CE  HE2  sing N N 259 
MET CE  HE3  sing N N 260 
MET OXT HXT  sing N N 261 
PHE N   CA   sing N N 262 
PHE N   H    sing N N 263 
PHE N   H2   sing N N 264 
PHE CA  C    sing N N 265 
PHE CA  CB   sing N N 266 
PHE CA  HA   sing N N 267 
PHE C   O    doub N N 268 
PHE C   OXT  sing N N 269 
PHE CB  CG   sing N N 270 
PHE CB  HB2  sing N N 271 
PHE CB  HB3  sing N N 272 
PHE CG  CD1  doub Y N 273 
PHE CG  CD2  sing Y N 274 
PHE CD1 CE1  sing Y N 275 
PHE CD1 HD1  sing N N 276 
PHE CD2 CE2  doub Y N 277 
PHE CD2 HD2  sing N N 278 
PHE CE1 CZ   doub Y N 279 
PHE CE1 HE1  sing N N 280 
PHE CE2 CZ   sing Y N 281 
PHE CE2 HE2  sing N N 282 
PHE CZ  HZ   sing N N 283 
PHE OXT HXT  sing N N 284 
PRO N   CA   sing N N 285 
PRO N   CD   sing N N 286 
PRO N   H    sing N N 287 
PRO CA  C    sing N N 288 
PRO CA  CB   sing N N 289 
PRO CA  HA   sing N N 290 
PRO C   O    doub N N 291 
PRO C   OXT  sing N N 292 
PRO CB  CG   sing N N 293 
PRO CB  HB2  sing N N 294 
PRO CB  HB3  sing N N 295 
PRO CG  CD   sing N N 296 
PRO CG  HG2  sing N N 297 
PRO CG  HG3  sing N N 298 
PRO CD  HD2  sing N N 299 
PRO CD  HD3  sing N N 300 
PRO OXT HXT  sing N N 301 
SER N   CA   sing N N 302 
SER N   H    sing N N 303 
SER N   H2   sing N N 304 
SER CA  C    sing N N 305 
SER CA  CB   sing N N 306 
SER CA  HA   sing N N 307 
SER C   O    doub N N 308 
SER C   OXT  sing N N 309 
SER CB  OG   sing N N 310 
SER CB  HB2  sing N N 311 
SER CB  HB3  sing N N 312 
SER OG  HG   sing N N 313 
SER OXT HXT  sing N N 314 
SO4 S   O1   doub N N 315 
SO4 S   O2   doub N N 316 
SO4 S   O3   sing N N 317 
SO4 S   O4   sing N N 318 
THR N   CA   sing N N 319 
THR N   H    sing N N 320 
THR N   H2   sing N N 321 
THR CA  C    sing N N 322 
THR CA  CB   sing N N 323 
THR CA  HA   sing N N 324 
THR C   O    doub N N 325 
THR C   OXT  sing N N 326 
THR CB  OG1  sing N N 327 
THR CB  CG2  sing N N 328 
THR CB  HB   sing N N 329 
THR OG1 HG1  sing N N 330 
THR CG2 HG21 sing N N 331 
THR CG2 HG22 sing N N 332 
THR CG2 HG23 sing N N 333 
THR OXT HXT  sing N N 334 
TRP N   CA   sing N N 335 
TRP N   H    sing N N 336 
TRP N   H2   sing N N 337 
TRP CA  C    sing N N 338 
TRP CA  CB   sing N N 339 
TRP CA  HA   sing N N 340 
TRP C   O    doub N N 341 
TRP C   OXT  sing N N 342 
TRP CB  CG   sing N N 343 
TRP CB  HB2  sing N N 344 
TRP CB  HB3  sing N N 345 
TRP CG  CD1  doub Y N 346 
TRP CG  CD2  sing Y N 347 
TRP CD1 NE1  sing Y N 348 
TRP CD1 HD1  sing N N 349 
TRP CD2 CE2  doub Y N 350 
TRP CD2 CE3  sing Y N 351 
TRP NE1 CE2  sing Y N 352 
TRP NE1 HE1  sing N N 353 
TRP CE2 CZ2  sing Y N 354 
TRP CE3 CZ3  doub Y N 355 
TRP CE3 HE3  sing N N 356 
TRP CZ2 CH2  doub Y N 357 
TRP CZ2 HZ2  sing N N 358 
TRP CZ3 CH2  sing Y N 359 
TRP CZ3 HZ3  sing N N 360 
TRP CH2 HH2  sing N N 361 
TRP OXT HXT  sing N N 362 
TYR N   CA   sing N N 363 
TYR N   H    sing N N 364 
TYR N   H2   sing N N 365 
TYR CA  C    sing N N 366 
TYR CA  CB   sing N N 367 
TYR CA  HA   sing N N 368 
TYR C   O    doub N N 369 
TYR C   OXT  sing N N 370 
TYR CB  CG   sing N N 371 
TYR CB  HB2  sing N N 372 
TYR CB  HB3  sing N N 373 
TYR CG  CD1  doub Y N 374 
TYR CG  CD2  sing Y N 375 
TYR CD1 CE1  sing Y N 376 
TYR CD1 HD1  sing N N 377 
TYR CD2 CE2  doub Y N 378 
TYR CD2 HD2  sing N N 379 
TYR CE1 CZ   doub Y N 380 
TYR CE1 HE1  sing N N 381 
TYR CE2 CZ   sing Y N 382 
TYR CE2 HE2  sing N N 383 
TYR CZ  OH   sing N N 384 
TYR OH  HH   sing N N 385 
TYR OXT HXT  sing N N 386 
VAL N   CA   sing N N 387 
VAL N   H    sing N N 388 
VAL N   H2   sing N N 389 
VAL CA  C    sing N N 390 
VAL CA  CB   sing N N 391 
VAL CA  HA   sing N N 392 
VAL C   O    doub N N 393 
VAL C   OXT  sing N N 394 
VAL CB  CG1  sing N N 395 
VAL CB  CG2  sing N N 396 
VAL CB  HB   sing N N 397 
VAL CG1 HG11 sing N N 398 
VAL CG1 HG12 sing N N 399 
VAL CG1 HG13 sing N N 400 
VAL CG2 HG21 sing N N 401 
VAL CG2 HG22 sing N N 402 
VAL CG2 HG23 sing N N 403 
VAL OXT HXT  sing N N 404 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Cancer Institute (NIH/NCI)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 GCS 1 n 
3 GCS 2 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'TG10 apo, same sequence' 
# 
_atom_sites.entry_id                    8TN7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.010978 
_atom_sites.fract_transf_matrix[1][2]   0.006338 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012676 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004944 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLU A 1 1   ? 25.446  24.435 74.793  1.00 56.22 ? 1   GLU H N   1 
ATOM   2    C  CA  . GLU A 1 1   ? 25.372  25.675 75.617  1.00 54.34 ? 1   GLU H CA  1 
ATOM   3    C  C   . GLU A 1 1   ? 23.901  25.956 75.946  1.00 43.99 ? 1   GLU H C   1 
ATOM   4    O  O   . GLU A 1 1   ? 23.155  26.403 75.075  1.00 43.55 ? 1   GLU H O   1 
ATOM   5    C  CB  . GLU A 1 1   ? 26.050  26.809 74.845  1.00 59.14 ? 1   GLU H CB  1 
ATOM   6    C  CG  . GLU A 1 1   ? 25.717  28.203 75.351  1.00 70.86 ? 1   GLU H CG  1 
ATOM   7    C  CD  . GLU A 1 1   ? 25.885  28.398 76.846  1.00 72.69 ? 1   GLU H CD  1 
ATOM   8    O  OE1 . GLU A 1 1   ? 26.231  27.418 77.529  1.00 72.40 ? 1   GLU H OE1 1 
ATOM   9    O  OE2 . GLU A 1 1   ? 25.671  29.533 77.318  1.00 82.07 ? 1   GLU H OE2 1 
ATOM   10   N  N   . VAL A 1 2   ? 23.480  25.672 77.190  1.00 31.64 ? 2   VAL H N   1 
ATOM   11   C  CA  . VAL A 1 2   ? 22.051  25.716 77.504  1.00 29.10 ? 2   VAL H CA  1 
ATOM   12   C  C   . VAL A 1 2   ? 21.645  27.134 77.857  1.00 28.31 ? 2   VAL H C   1 
ATOM   13   O  O   . VAL A 1 2   ? 22.314  27.790 78.660  1.00 26.79 ? 2   VAL H O   1 
ATOM   14   C  CB  . VAL A 1 2   ? 21.703  24.725 78.633  1.00 31.35 ? 2   VAL H CB  1 
ATOM   15   C  CG1 . VAL A 1 2   ? 20.250  24.789 79.071  1.00 27.52 ? 2   VAL H CG1 1 
ATOM   16   C  CG2 . VAL A 1 2   ? 22.064  23.310 78.250  1.00 32.49 ? 2   VAL H CG2 1 
ATOM   17   N  N   . GLN A 1 3   ? 20.550  27.613 77.243  1.00 21.92 ? 3   GLN H N   1 
ATOM   18   C  CA  . GLN A 1 3   ? 20.075  28.944 77.512  1.00 24.40 ? 3   GLN H CA  1 
ATOM   19   C  C   . GLN A 1 3   ? 18.547  28.921 77.522  1.00 21.02 ? 3   GLN H C   1 
ATOM   20   O  O   . GLN A 1 3   ? 17.957  28.201 76.730  1.00 21.42 ? 3   GLN H O   1 
ATOM   21   C  CB  . GLN A 1 3   ? 20.459  29.948 76.438  1.00 29.22 ? 3   GLN H CB  1 
ATOM   22   C  CG  . GLN A 1 3   ? 21.955  30.151 76.223  1.00 40.68 ? 3   GLN H CG  1 
ATOM   23   C  CD  . GLN A 1 3   ? 22.124  31.290 75.235  1.00 52.77 ? 3   GLN H CD  1 
ATOM   24   O  OE1 . GLN A 1 3   ? 21.741  32.436 75.493  1.00 57.01 ? 3   GLN H OE1 1 
ATOM   25   N  NE2 . GLN A 1 3   ? 22.625  30.969 74.053  1.00 56.92 ? 3   GLN H NE2 1 
ATOM   26   N  N   . LEU A 1 4   ? 17.930  29.605 78.500  1.00 20.11 ? 4   LEU H N   1 
ATOM   27   C  CA  . LEU A 1 4   ? 16.496  29.809 78.533  1.00 19.17 ? 4   LEU H CA  1 
ATOM   28   C  C   . LEU A 1 4   ? 16.309  31.302 78.724  1.00 22.88 ? 4   LEU H C   1 
ATOM   29   O  O   . LEU A 1 4   ? 16.765  31.841 79.711  1.00 22.28 ? 4   LEU H O   1 
ATOM   30   C  CB  . LEU A 1 4   ? 15.815  29.003 79.641  1.00 17.92 ? 4   LEU H CB  1 
ATOM   31   C  CG  . LEU A 1 4   ? 15.793  27.489 79.492  1.00 17.95 ? 4   LEU H CG  1 
ATOM   32   C  CD1 . LEU A 1 4   ? 17.066  26.880 80.067  1.00 19.09 ? 4   LEU H CD1 1 
ATOM   33   C  CD2 . LEU A 1 4   ? 14.577  26.863 80.156  1.00 18.70 ? 4   LEU H CD2 1 
ATOM   34   N  N   . VAL A 1 5   ? 15.718  31.986 77.739  1.00 20.33 ? 5   VAL H N   1 
ATOM   35   C  CA  . VAL A 1 5   ? 15.633  33.428 77.753  1.00 20.32 ? 5   VAL H CA  1 
ATOM   36   C  C   . VAL A 1 5   ? 14.171  33.854 77.809  1.00 18.85 ? 5   VAL H C   1 
ATOM   37   O  O   . VAL A 1 5   ? 13.442  33.648 76.825  1.00 19.73 ? 5   VAL H O   1 
ATOM   38   C  CB  . VAL A 1 5   ? 16.325  34.037 76.525  1.00 22.58 ? 5   VAL H CB  1 
ATOM   39   C  CG1 . VAL A 1 5   ? 16.284  35.546 76.592  1.00 23.04 ? 5   VAL H CG1 1 
ATOM   40   C  CG2 . VAL A 1 5   ? 17.757  33.522 76.423  1.00 24.96 ? 5   VAL H CG2 1 
ATOM   41   N  N   . GLU A 1 6   ? 13.803  34.494 78.925  1.00 19.25 ? 6   GLU H N   1 
ATOM   42   C  CA  . GLU A 1 6   ? 12.454  34.970 79.146  1.00 19.10 ? 6   GLU H CA  1 
ATOM   43   C  C   . GLU A 1 6   ? 12.276  36.407 78.662  1.00 19.47 ? 6   GLU H C   1 
ATOM   44   O  O   . GLU A 1 6   ? 13.161  37.258 78.719  1.00 20.38 ? 6   GLU H O   1 
ATOM   45   C  CB  . GLU A 1 6   ? 12.109  34.862 80.614  1.00 20.11 ? 6   GLU H CB  1 
ATOM   46   C  CG  . GLU A 1 6   ? 12.314  33.454 81.094  1.00 22.43 ? 6   GLU H CG  1 
ATOM   47   C  CD  . GLU A 1 6   ? 12.001  33.360 82.553  1.00 22.93 ? 6   GLU H CD  1 
ATOM   48   O  OE1 . GLU A 1 6   ? 12.701  32.611 83.239  1.00 20.33 ? 6   GLU H OE1 1 
ATOM   49   O  OE2 . GLU A 1 6   ? 10.934  33.937 82.950  1.00 24.08 ? 6   GLU H OE2 1 
ATOM   50   N  N   . SER A 1 7   ? 11.077  36.700 78.191  1.00 18.50 ? 7   SER H N   1 
ATOM   51   C  CA  . SER A 1 7   ? 10.621  38.035 77.885  1.00 18.25 ? 7   SER H CA  1 
ATOM   52   C  C   . SER A 1 7   ? 9.134   38.172 78.171  1.00 17.83 ? 7   SER H C   1 
ATOM   53   O  O   . SER A 1 7   ? 8.456   37.166 78.415  1.00 18.35 ? 7   SER H O   1 
ATOM   54   C  CB  . SER A 1 7   ? 10.927  38.425 76.478  1.00 21.62 ? 7   SER H CB  1 
ATOM   55   O  OG  . SER A 1 7   ? 10.422  37.489 75.578  1.00 23.49 ? 7   SER H OG  1 
ATOM   56   N  N   . GLY A 1 8   ? 8.657   39.420 78.154  1.00 18.52 ? 8   GLY H N   1 
ATOM   57   C  CA  . GLY A 1 8   ? 7.227   39.657 78.268  1.00 17.82 ? 8   GLY H CA  1 
ATOM   58   C  C   . GLY A 1 8   ? 6.733   40.104 79.633  1.00 19.98 ? 8   GLY H C   1 
ATOM   59   O  O   . GLY A 1 8   ? 5.537   40.369 79.740  1.00 20.16 ? 8   GLY H O   1 
ATOM   60   N  N   . GLY A 1 9   ? 7.628   40.195 80.643  1.00 19.98 ? 9   GLY H N   1 
ATOM   61   C  CA  . GLY A 1 9   ? 7.221   40.627 81.968  1.00 19.62 ? 9   GLY H CA  1 
ATOM   62   C  C   . GLY A 1 9   ? 7.132   42.140 82.143  1.00 22.28 ? 9   GLY H C   1 
ATOM   63   O  O   . GLY A 1 9   ? 6.916   42.874 81.181  1.00 23.40 ? 9   GLY H O   1 
ATOM   64   N  N   . GLY A 1 10  ? 7.304   42.587 83.387  1.00 20.83 ? 11  GLY H N   1 
ATOM   65   C  CA  . GLY A 1 10  ? 7.334   44.003 83.737  1.00 19.49 ? 11  GLY H CA  1 
ATOM   66   C  C   . GLY A 1 10  ? 6.102   44.457 84.478  1.00 18.51 ? 11  GLY H C   1 
ATOM   67   O  O   . GLY A 1 10  ? 5.410   43.643 85.084  1.00 18.28 ? 11  GLY H O   1 
ATOM   68   N  N   . LEU A 1 11  ? 5.899   45.789 84.469  1.00 18.27 ? 12  LEU H N   1 
ATOM   69   C  CA  . LEU A 1 11  ? 4.833   46.426 85.219  1.00 19.29 ? 12  LEU H CA  1 
ATOM   70   C  C   . LEU A 1 11  ? 3.527   46.264 84.456  1.00 19.97 ? 12  LEU H C   1 
ATOM   71   O  O   . LEU A 1 11  ? 3.516   46.454 83.246  1.00 23.40 ? 12  LEU H O   1 
ATOM   72   C  CB  . LEU A 1 11  ? 5.153   47.917 85.352  1.00 21.43 ? 12  LEU H CB  1 
ATOM   73   C  CG  . LEU A 1 11  ? 4.118   48.788 86.058  1.00 23.27 ? 12  LEU H CG  1 
ATOM   74   C  CD1 . LEU A 1 11  ? 3.966   48.445 87.526  1.00 21.22 ? 12  LEU H CD1 1 
ATOM   75   C  CD2 . LEU A 1 11  ? 4.485   50.248 85.914  1.00 25.23 ? 12  LEU H CD2 1 
ATOM   76   N  N   . VAL A 1 12  ? 2.474   45.875 85.168  1.00 18.13 ? 13  VAL H N   1 
ATOM   77   C  CA  . VAL A 1 12  ? 1.171   45.685 84.566  1.00 16.56 ? 13  VAL H CA  1 
ATOM   78   C  C   . VAL A 1 12  ? 0.107   46.133 85.560  1.00 18.07 ? 13  VAL H C   1 
ATOM   79   O  O   . VAL A 1 12  ? 0.248   45.970 86.762  1.00 20.16 ? 13  VAL H O   1 
ATOM   80   C  CB  . VAL A 1 12  ? 0.965   44.226 84.105  1.00 17.99 ? 13  VAL H CB  1 
ATOM   81   C  CG1 . VAL A 1 12  ? 1.090   43.238 85.243  1.00 19.04 ? 13  VAL H CG1 1 
ATOM   82   C  CG2 . VAL A 1 12  ? -0.373  44.022 83.394  1.00 19.98 ? 13  VAL H CG2 1 
ATOM   83   N  N   . GLN A 1 13  ? -0.930  46.777 85.008  1.00 20.03 ? 14  GLN H N   1 
ATOM   84   C  CA  . GLN A 1 13  ? -2.096  47.227 85.756  1.00 22.91 ? 14  GLN H CA  1 
ATOM   85   C  C   . GLN A 1 13  ? -2.802  46.023 86.392  1.00 20.99 ? 14  GLN H C   1 
ATOM   86   O  O   . GLN A 1 13  ? -3.028  45.003 85.754  1.00 18.37 ? 14  GLN H O   1 
ATOM   87   C  CB  . GLN A 1 13  ? -3.058  47.926 84.779  1.00 26.02 ? 14  GLN H CB  1 
ATOM   88   C  CG  . GLN A 1 13  ? -2.978  47.390 83.327  1.00 33.73 ? 14  GLN H CG  1 
ATOM   89   C  CD  . GLN A 1 13  ? -1.806  47.863 82.465  1.00 47.35 ? 14  GLN H CD  1 
ATOM   90   O  OE1 . GLN A 1 13  ? -1.030  47.101 81.870  1.00 40.05 ? 14  GLN H OE1 1 
ATOM   91   N  NE2 . GLN A 1 13  ? -1.695  49.173 82.310  1.00 68.80 ? 14  GLN H NE2 1 
ATOM   92   N  N   . PRO A 1 14  ? -3.295  46.115 87.633  1.00 19.53 ? 15  PRO H N   1 
ATOM   93   C  CA  . PRO A 1 14  ? -4.207  45.128 88.207  1.00 19.26 ? 15  PRO H CA  1 
ATOM   94   C  C   . PRO A 1 14  ? -5.412  44.967 87.273  1.00 17.64 ? 15  PRO H C   1 
ATOM   95   O  O   . PRO A 1 14  ? -5.953  45.956 86.721  1.00 17.73 ? 15  PRO H O   1 
ATOM   96   C  CB  . PRO A 1 14  ? -4.674  45.726 89.554  1.00 20.12 ? 15  PRO H CB  1 
ATOM   97   C  CG  . PRO A 1 14  ? -3.646  46.783 89.825  1.00 21.80 ? 15  PRO H CG  1 
ATOM   98   C  CD  . PRO A 1 14  ? -3.017  47.231 88.540  1.00 22.72 ? 15  PRO H CD  1 
ATOM   99   N  N   . GLY A 1 15  ? -5.772  43.711 87.046  1.00 17.84 ? 16  GLY H N   1 
ATOM   100  C  CA  . GLY A 1 15  ? -6.843  43.374 86.115  1.00 16.84 ? 16  GLY H CA  1 
ATOM   101  C  C   . GLY A 1 15  ? -6.346  43.142 84.703  1.00 17.83 ? 16  GLY H C   1 
ATOM   102  O  O   . GLY A 1 15  ? -7.104  42.691 83.857  1.00 19.79 ? 16  GLY H O   1 
ATOM   103  N  N   . GLY A 1 16  ? -5.073  43.467 84.456  1.00 15.96 ? 17  GLY H N   1 
ATOM   104  C  CA  . GLY A 1 16  ? -4.509  43.338 83.132  1.00 17.20 ? 17  GLY H CA  1 
ATOM   105  C  C   . GLY A 1 16  ? -3.944  41.949 82.852  1.00 14.84 ? 17  GLY H C   1 
ATOM   106  O  O   . GLY A 1 16  ? -4.233  40.991 83.558  1.00 16.26 ? 17  GLY H O   1 
ATOM   107  N  N   . SER A 1 17  ? -3.165  41.900 81.757  1.00 15.53 ? 18  SER H N   1 
ATOM   108  C  CA  . SER A 1 17  ? -2.628  40.646 81.247  1.00 15.69 ? 18  SER H CA  1 
ATOM   109  C  C   . SER A 1 17  ? -1.202  40.851 80.772  1.00 15.27 ? 18  SER H C   1 
ATOM   110  O  O   . SER A 1 17  ? -0.791  41.966 80.419  1.00 15.30 ? 18  SER H O   1 
ATOM   111  C  CB  . SER A 1 17  ? -3.493  40.097 80.120  1.00 16.43 ? 18  SER H CB  1 
ATOM   112  O  OG  . SER A 1 17  ? -3.423  40.890 78.942  1.00 16.49 ? 18  SER H OG  1 
ATOM   113  N  N   . LEU A 1 18  ? -0.430  39.753 80.799  1.00 16.52 ? 19  LEU H N   1 
ATOM   114  C  CA  . LEU A 1 18  ? 0.891   39.669 80.218  1.00 15.65 ? 19  LEU H CA  1 
ATOM   115  C  C   . LEU A 1 18  ? 1.026   38.349 79.496  1.00 15.64 ? 19  LEU H C   1 
ATOM   116  O  O   . LEU A 1 18  ? 0.359   37.367 79.830  1.00 16.72 ? 19  LEU H O   1 
ATOM   117  C  CB  . LEU A 1 18  ? 1.978   39.731 81.293  1.00 15.80 ? 19  LEU H CB  1 
ATOM   118  C  CG  . LEU A 1 18  ? 2.150   41.072 81.979  1.00 17.03 ? 19  LEU H CG  1 
ATOM   119  C  CD1 . LEU A 1 18  ? 3.112   40.915 83.144  1.00 18.50 ? 19  LEU H CD1 1 
ATOM   120  C  CD2 . LEU A 1 18  ? 2.691   42.125 81.009  1.00 17.82 ? 19  LEU H CD2 1 
ATOM   121  N  N   . ARG A 1 19  ? 1.924   38.337 78.524  1.00 14.93 ? 20  ARG H N   1 
ATOM   122  C  CA  . ARG A 1 19  ? 2.281   37.151 77.765  1.00 14.71 ? 20  ARG H CA  1 
ATOM   123  C  C   . ARG A 1 19  ? 3.747   36.895 78.016  1.00 15.75 ? 20  ARG H C   1 
ATOM   124  O  O   . ARG A 1 19  ? 4.560   37.706 77.571  1.00 17.05 ? 20  ARG H O   1 
ATOM   125  C  CB  . ARG A 1 19  ? 2.043   37.356 76.273  1.00 16.69 ? 20  ARG H CB  1 
ATOM   126  C  CG  . ARG A 1 19  ? 2.373   36.153 75.383  1.00 16.14 ? 20  ARG H CG  1 
ATOM   127  C  CD  . ARG A 1 19  ? 2.369   36.579 73.938  1.00 18.05 ? 20  ARG H CD  1 
ATOM   128  N  NE  . ARG A 1 19  ? 3.478   37.440 73.668  1.00 18.47 ? 20  ARG H NE  1 
ATOM   129  C  CZ  . ARG A 1 19  ? 3.809   37.915 72.479  1.00 20.99 ? 20  ARG H CZ  1 
ATOM   130  N  NH1 . ARG A 1 19  ? 4.940   38.597 72.306  1.00 22.77 ? 20  ARG H NH1 1 
ATOM   131  N  NH2 . ARG A 1 19  ? 2.998   37.671 71.461  1.00 19.40 ? 20  ARG H NH2 1 
ATOM   132  N  N   . LEU A 1 20  ? 4.082   35.848 78.770  1.00 14.62 ? 21  LEU H N   1 
ATOM   133  C  CA  . LEU A 1 20  ? 5.481   35.521 78.999  1.00 14.54 ? 21  LEU H CA  1 
ATOM   134  C  C   . LEU A 1 20  ? 5.943   34.507 77.965  1.00 15.48 ? 21  LEU H C   1 
ATOM   135  O  O   . LEU A 1 20  ? 5.222   33.556 77.644  1.00 16.77 ? 21  LEU H O   1 
ATOM   136  C  CB  . LEU A 1 20  ? 5.713   34.930 80.398  1.00 15.62 ? 21  LEU H CB  1 
ATOM   137  C  CG  . LEU A 1 20  ? 5.197   35.742 81.580  1.00 16.57 ? 21  LEU H CG  1 
ATOM   138  C  CD1 . LEU A 1 20  ? 5.618   35.106 82.897  1.00 17.86 ? 21  LEU H CD1 1 
ATOM   139  C  CD2 . LEU A 1 20  ? 5.677   37.170 81.510  1.00 18.13 ? 21  LEU H CD2 1 
ATOM   140  N  N   . SER A 1 21  ? 7.160   34.742 77.429  1.00 16.35 ? 22  SER H N   1 
ATOM   141  C  CA  . SER A 1 21  ? 7.803   33.858 76.470  1.00 17.03 ? 22  SER H CA  1 
ATOM   142  C  C   . SER A 1 21  ? 9.108   33.339 77.057  1.00 17.75 ? 22  SER H C   1 
ATOM   143  O  O   . SER A 1 21  ? 9.747   34.057 77.788  1.00 18.71 ? 22  SER H O   1 
ATOM   144  C  CB  . SER A 1 21  ? 8.096   34.616 75.183  1.00 17.70 ? 22  SER H CB  1 
ATOM   145  O  OG  . SER A 1 21  ? 6.846   34.994 74.520  1.00 21.09 ? 22  SER H OG  1 
ATOM   146  N  N   . CYS A 1 22  ? 9.536   32.162 76.661  1.00 17.63 ? 23  CYS H N   1 
ATOM   147  C  CA  . CYS A 1 22  ? 10.785  31.577 77.065  1.00 18.70 ? 23  CYS H CA  1 
ATOM   148  C  C   . CYS A 1 22  ? 11.375  30.784 75.872  1.00 18.98 ? 23  CYS H C   1 
ATOM   149  O  O   . CYS A 1 22  ? 10.827  29.769 75.475  1.00 19.80 ? 23  CYS H O   1 
ATOM   150  C  CB  . CYS A 1 22  ? 10.515  30.675 78.245  1.00 18.78 ? 23  CYS H CB  1 
ATOM   151  S  SG  . CYS A 1 22  ? 11.930  29.632 78.707  1.00 24.57 ? 23  CYS H SG  1 
ATOM   152  N  N   . ALA A 1 23  ? 12.493  31.285 75.330  1.00 19.09 ? 24  ALA H N   1 
ATOM   153  C  CA  . ALA A 1 23  ? 13.176  30.676 74.196  1.00 20.26 ? 24  ALA H CA  1 
ATOM   154  C  C   . ALA A 1 23  ? 14.314  29.803 74.714  1.00 20.80 ? 24  ALA H C   1 
ATOM   155  O  O   . ALA A 1 23  ? 15.208  30.327 75.399  1.00 22.03 ? 24  ALA H O   1 
ATOM   156  C  CB  . ALA A 1 23  ? 13.682  31.773 73.310  1.00 21.22 ? 24  ALA H CB  1 
ATOM   157  N  N   . VAL A 1 24  ? 14.241  28.510 74.397  1.00 19.88 ? 25  VAL H N   1 
ATOM   158  C  CA  . VAL A 1 24  ? 15.136  27.495 74.953  1.00 20.45 ? 25  VAL H CA  1 
ATOM   159  C  C   . VAL A 1 24  ? 16.072  27.063 73.833  1.00 24.33 ? 25  VAL H C   1 
ATOM   160  O  O   . VAL A 1 24  ? 15.668  26.973 72.673  1.00 25.47 ? 25  VAL H O   1 
ATOM   161  C  CB  . VAL A 1 24  ? 14.326  26.308 75.513  1.00 23.05 ? 25  VAL H CB  1 
ATOM   162  C  CG1 . VAL A 1 24  ? 15.113  25.178 76.139  1.00 24.28 ? 25  VAL H CG1 1 
ATOM   163  C  CG2 . VAL A 1 24  ? 13.282  26.804 76.512  1.00 22.70 ? 25  VAL H CG2 1 
ATOM   164  N  N   . SER A 1 25  ? 17.331  26.840 74.200  1.00 20.31 ? 26  SER H N   1 
ATOM   165  C  CA  . SER A 1 25  ? 18.304  26.220 73.306  1.00 22.98 ? 26  SER H CA  1 
ATOM   166  C  C   . SER A 1 25  ? 19.261  25.327 74.108  1.00 26.64 ? 26  SER H C   1 
ATOM   167  O  O   . SER A 1 25  ? 19.431  25.499 75.304  1.00 22.47 ? 26  SER H O   1 
ATOM   168  C  CB  . SER A 1 25  ? 19.024  27.259 72.499  1.00 27.26 ? 26  SER H CB  1 
ATOM   169  O  OG  . SER A 1 25  ? 19.767  28.174 73.281  1.00 29.01 ? 26  SER H OG  1 
ATOM   170  N  N   . GLY A 1 26  ? 19.837  24.298 73.459  1.00 25.21 ? 27  GLY H N   1 
ATOM   171  C  CA  . GLY A 1 26  ? 20.936  23.568 74.076  1.00 21.20 ? 27  GLY H CA  1 
ATOM   172  C  C   . GLY A 1 26  ? 20.546  22.195 74.595  1.00 23.57 ? 27  GLY H C   1 
ATOM   173  O  O   . GLY A 1 26  ? 21.403  21.451 75.041  1.00 28.22 ? 27  GLY H O   1 
ATOM   174  N  N   . PHE A 1 27  ? 19.270  21.829 74.549  1.00 21.53 ? 28  PHE H N   1 
ATOM   175  C  CA  . PHE A 1 27  ? 18.831  20.479 74.812  1.00 23.03 ? 28  PHE H CA  1 
ATOM   176  C  C   . PHE A 1 27  ? 17.542  20.237 74.037  1.00 22.04 ? 28  PHE H C   1 
ATOM   177  O  O   . PHE A 1 27  ? 17.008  21.219 73.502  1.00 21.28 ? 28  PHE H O   1 
ATOM   178  C  CB  . PHE A 1 27  ? 18.584  20.222 76.303  1.00 25.56 ? 28  PHE H CB  1 
ATOM   179  C  CG  . PHE A 1 27  ? 17.440  20.983 76.942  1.00 22.76 ? 28  PHE H CG  1 
ATOM   180  C  CD1 . PHE A 1 27  ? 17.623  22.260 77.448  1.00 25.28 ? 28  PHE H CD1 1 
ATOM   181  C  CD2 . PHE A 1 27  ? 16.203  20.412 77.053  1.00 22.69 ? 28  PHE H CD2 1 
ATOM   182  C  CE1 . PHE A 1 27  ? 16.574  22.951 78.043  1.00 24.91 ? 28  PHE H CE1 1 
ATOM   183  C  CE2 . PHE A 1 27  ? 15.155  21.122 77.622  1.00 23.66 ? 28  PHE H CE2 1 
ATOM   184  C  CZ  . PHE A 1 27  ? 15.352  22.384 78.117  1.00 25.72 ? 28  PHE H CZ  1 
ATOM   185  N  N   . PRO A 1 28  ? 17.067  18.986 73.928  1.00 22.51 ? 29  PRO H N   1 
ATOM   186  C  CA  . PRO A 1 28  ? 15.870  18.660 73.161  1.00 21.35 ? 29  PRO H CA  1 
ATOM   187  C  C   . PRO A 1 28  ? 14.607  19.000 73.931  1.00 18.41 ? 29  PRO H C   1 
ATOM   188  O  O   . PRO A 1 28  ? 14.016  18.166 74.583  1.00 18.76 ? 29  PRO H O   1 
ATOM   189  C  CB  . PRO A 1 28  ? 15.917  17.164 72.874  1.00 23.43 ? 29  PRO H CB  1 
ATOM   190  C  CG  . PRO A 1 28  ? 16.936  16.603 73.853  1.00 25.67 ? 29  PRO H CG  1 
ATOM   191  C  CD  . PRO A 1 28  ? 17.733  17.756 74.413  1.00 23.68 ? 29  PRO H CD  1 
ATOM   192  N  N   . PHE A 1 29  ? 14.223  20.256 73.765  1.00 23.08 ? 30  PHE H N   1 
ATOM   193  C  CA  . PHE A 1 29  ? 13.057  20.823 74.419  1.00 20.89 ? 30  PHE H CA  1 
ATOM   194  C  C   . PHE A 1 29  ? 11.857  19.903 74.284  1.00 19.66 ? 30  PHE H C   1 
ATOM   195  O  O   . PHE A 1 29  ? 11.127  19.726 75.245  1.00 20.45 ? 30  PHE H O   1 
ATOM   196  C  CB  . PHE A 1 29  ? 12.838  22.201 73.808  1.00 20.07 ? 30  PHE H CB  1 
ATOM   197  C  CG  . PHE A 1 29  ? 11.607  22.938 74.253  1.00 19.81 ? 30  PHE H CG  1 
ATOM   198  C  CD1 . PHE A 1 29  ? 11.576  23.603 75.451  1.00 19.14 ? 30  PHE H CD1 1 
ATOM   199  C  CD2 . PHE A 1 29  ? 10.507  23.022 73.422  1.00 20.57 ? 30  PHE H CD2 1 
ATOM   200  C  CE1 . PHE A 1 29  ? 10.442  24.324 75.830  1.00 19.44 ? 30  PHE H CE1 1 
ATOM   201  C  CE2 . PHE A 1 29  ? 9.385   23.746 73.786  1.00 21.11 ? 30  PHE H CE2 1 
ATOM   202  C  CZ  . PHE A 1 29  ? 9.359   24.416 74.978  1.00 18.69 ? 30  PHE H CZ  1 
ATOM   203  N  N   . SER A 1 30  ? 11.560  19.401 73.052  1.00 23.90 ? 35  SER H N   1 
ATOM   204  C  CA  . SER A 1 30  ? 10.359  18.644 72.775  1.00 25.99 ? 35  SER H CA  1 
ATOM   205  C  C   . SER A 1 30  ? 10.304  17.280 73.459  1.00 24.53 ? 35  SER H C   1 
ATOM   206  O  O   . SER A 1 30  ? 9.289   16.569 73.377  1.00 26.58 ? 35  SER H O   1 
ATOM   207  C  CB  . SER A 1 30  ? 10.165  18.520 71.279  1.00 29.67 ? 35  SER H CB  1 
ATOM   208  O  OG  . SER A 1 30  ? 11.125  17.637 70.757  1.00 32.33 ? 35  SER H OG  1 
ATOM   209  N  N   . SER A 1 31  ? 11.401  16.857 74.106  1.00 23.76 ? 36  SER H N   1 
ATOM   210  C  CA  . SER A 1 31  ? 11.389  15.639 74.887  1.00 23.99 ? 36  SER H CA  1 
ATOM   211  C  C   . SER A 1 31  ? 10.921  15.829 76.322  1.00 25.00 ? 36  SER H C   1 
ATOM   212  O  O   . SER A 1 31  ? 10.768  14.826 77.003  1.00 25.88 ? 36  SER H O   1 
ATOM   213  C  CB  . SER A 1 31  ? 12.759  15.016 74.917  1.00 26.53 ? 36  SER H CB  1 
ATOM   214  O  OG  . SER A 1 31  ? 13.125  14.606 73.623  1.00 27.35 ? 36  SER H OG  1 
ATOM   215  N  N   . TYR A 1 32  ? 10.815  17.072 76.831  1.00 20.71 ? 37  TYR H N   1 
ATOM   216  C  CA  . TYR A 1 32  ? 10.640  17.264 78.254  1.00 22.15 ? 37  TYR H CA  1 
ATOM   217  C  C   . TYR A 1 32  ? 9.377   18.031 78.600  1.00 18.14 ? 37  TYR H C   1 
ATOM   218  O  O   . TYR A 1 32  ? 8.976   18.968 77.891  1.00 18.64 ? 37  TYR H O   1 
ATOM   219  C  CB  . TYR A 1 32  ? 11.827  18.046 78.835  1.00 21.22 ? 37  TYR H CB  1 
ATOM   220  C  CG  . TYR A 1 32  ? 13.060  17.190 78.852  1.00 21.90 ? 37  TYR H CG  1 
ATOM   221  C  CD1 . TYR A 1 32  ? 13.241  16.248 79.872  1.00 22.50 ? 37  TYR H CD1 1 
ATOM   222  C  CD2 . TYR A 1 32  ? 13.959  17.206 77.797  1.00 21.46 ? 37  TYR H CD2 1 
ATOM   223  C  CE1 . TYR A 1 32  ? 14.335  15.409 79.902  1.00 22.52 ? 37  TYR H CE1 1 
ATOM   224  C  CE2 . TYR A 1 32  ? 15.037  16.330 77.791  1.00 23.26 ? 37  TYR H CE2 1 
ATOM   225  C  CZ  . TYR A 1 32  ? 15.229  15.449 78.846  1.00 24.24 ? 37  TYR H CZ  1 
ATOM   226  O  OH  . TYR A 1 32  ? 16.310  14.596 78.818  1.00 28.60 ? 37  TYR H OH  1 
ATOM   227  N  N   . TRP A 1 33  ? 8.808   17.638 79.728  1.00 20.61 ? 38  TRP H N   1 
ATOM   228  C  CA  . TRP A 1 33  ? 7.863   18.485 80.429  1.00 17.37 ? 38  TRP H CA  1 
ATOM   229  C  C   . TRP A 1 33  ? 8.548   19.811 80.767  1.00 19.14 ? 38  TRP H C   1 
ATOM   230  O  O   . TRP A 1 33  ? 9.741   19.880 81.022  1.00 18.65 ? 38  TRP H O   1 
ATOM   231  C  CB  . TRP A 1 33  ? 7.353   17.830 81.730  1.00 21.38 ? 38  TRP H CB  1 
ATOM   232  C  CG  . TRP A 1 33  ? 6.372   16.710 81.576  1.00 19.68 ? 38  TRP H CG  1 
ATOM   233  C  CD1 . TRP A 1 33  ? 6.582   15.500 80.991  1.00 25.42 ? 38  TRP H CD1 1 
ATOM   234  C  CD2 . TRP A 1 33  ? 5.022   16.680 82.086  1.00 20.93 ? 38  TRP H CD2 1 
ATOM   235  N  NE1 . TRP A 1 33  ? 5.444   14.748 81.039  1.00 23.38 ? 38  TRP H NE1 1 
ATOM   236  C  CE2 . TRP A 1 33  ? 4.468   15.442 81.700  1.00 20.53 ? 38  TRP H CE2 1 
ATOM   237  C  CE3 . TRP A 1 33  ? 4.185   17.606 82.692  1.00 20.85 ? 38  TRP H CE3 1 
ATOM   238  C  CZ2 . TRP A 1 33  ? 3.175   15.065 82.061  1.00 24.16 ? 38  TRP H CZ2 1 
ATOM   239  C  CZ3 . TRP A 1 33  ? 2.912   17.237 83.063  1.00 23.61 ? 38  TRP H CZ3 1 
ATOM   240  C  CH2 . TRP A 1 33  ? 2.392   15.996 82.695  1.00 24.49 ? 38  TRP H CH2 1 
ATOM   241  N  N   . MET A 1 34  ? 7.756   20.867 80.788  1.00 17.65 ? 39  MET H N   1 
ATOM   242  C  CA  . MET A 1 34  ? 8.235   22.204 81.138  1.00 16.72 ? 39  MET H CA  1 
ATOM   243  C  C   . MET A 1 34  ? 7.271   22.817 82.133  1.00 16.97 ? 39  MET H C   1 
ATOM   244  O  O   . MET A 1 34  ? 6.123   22.386 82.289  1.00 17.53 ? 39  MET H O   1 
ATOM   245  C  CB  . MET A 1 34  ? 8.272   23.113 79.896  1.00 17.59 ? 39  MET H CB  1 
ATOM   246  C  CG  . MET A 1 34  ? 9.330   22.757 78.874  1.00 18.24 ? 39  MET H CG  1 
ATOM   247  S  SD  . MET A 1 34  ? 11.047  22.843 79.422  1.00 20.06 ? 39  MET H SD  1 
ATOM   248  C  CE  . MET A 1 34  ? 11.160  24.559 79.946  1.00 20.32 ? 39  MET H CE  1 
ATOM   249  N  N   . SER A 1 35  ? 7.768   23.834 82.879  1.00 17.42 ? 40  SER H N   1 
ATOM   250  C  CA  . SER A 1 35  ? 6.978   24.449 83.928  1.00 17.42 ? 40  SER H CA  1 
ATOM   251  C  C   . SER A 1 35  ? 7.267   25.937 84.049  1.00 14.72 ? 40  SER H C   1 
ATOM   252  O  O   . SER A 1 35  ? 8.256   26.451 83.516  1.00 15.55 ? 40  SER H O   1 
ATOM   253  C  CB  . SER A 1 35  ? 7.162   23.800 85.262  1.00 18.47 ? 40  SER H CB  1 
ATOM   254  O  OG  . SER A 1 35  ? 8.462   24.032 85.709  1.00 20.06 ? 40  SER H OG  1 
ATOM   255  N  N   . TRP A 1 36  ? 6.339   26.590 84.750  1.00 16.17 ? 41  TRP H N   1 
ATOM   256  C  CA  . TRP A 1 36  ? 6.606   27.921 85.267  1.00 16.88 ? 41  TRP H CA  1 
ATOM   257  C  C   . TRP A 1 36  ? 6.579   27.883 86.788  1.00 14.70 ? 41  TRP H C   1 
ATOM   258  O  O   . TRP A 1 36  ? 5.717   27.237 87.349  1.00 15.84 ? 41  TRP H O   1 
ATOM   259  C  CB  . TRP A 1 36  ? 5.596   28.954 84.757  1.00 16.51 ? 41  TRP H CB  1 
ATOM   260  C  CG  . TRP A 1 36  ? 5.701   29.215 83.283  1.00 15.12 ? 41  TRP H CG  1 
ATOM   261  C  CD1 . TRP A 1 36  ? 4.970   28.582 82.317  1.00 15.43 ? 41  TRP H CD1 1 
ATOM   262  C  CD2 . TRP A 1 36  ? 6.539   30.177 82.616  1.00 13.86 ? 41  TRP H CD2 1 
ATOM   263  N  NE1 . TRP A 1 36  ? 5.331   29.031 81.087  1.00 15.26 ? 41  TRP H NE1 1 
ATOM   264  C  CE2 . TRP A 1 36  ? 6.282   30.025 81.223  1.00 14.31 ? 41  TRP H CE2 1 
ATOM   265  C  CE3 . TRP A 1 36  ? 7.439   31.167 83.053  1.00 13.61 ? 41  TRP H CE3 1 
ATOM   266  C  CZ2 . TRP A 1 36  ? 6.921   30.849 80.276  1.00 15.74 ? 41  TRP H CZ2 1 
ATOM   267  C  CZ3 . TRP A 1 36  ? 8.042   31.991 82.135  1.00 16.84 ? 41  TRP H CZ3 1 
ATOM   268  C  CH2 . TRP A 1 36  ? 7.826   31.792 80.744  1.00 15.82 ? 41  TRP H CH2 1 
ATOM   269  N  N   . VAL A 1 37  ? 7.525   28.613 87.409  1.00 15.64 ? 42  VAL H N   1 
ATOM   270  C  CA  . VAL A 1 37  ? 7.695   28.713 88.847  1.00 16.61 ? 42  VAL H CA  1 
ATOM   271  C  C   . VAL A 1 37  ? 7.840   30.194 89.160  1.00 15.80 ? 42  VAL H C   1 
ATOM   272  O  O   . VAL A 1 37  ? 8.484   30.890 88.376  1.00 18.25 ? 42  VAL H O   1 
ATOM   273  C  CB  . VAL A 1 37  ? 8.929   27.913 89.291  1.00 17.54 ? 42  VAL H CB  1 
ATOM   274  C  CG1 . VAL A 1 37  ? 9.194   28.121 90.792  1.00 18.17 ? 42  VAL H CG1 1 
ATOM   275  C  CG2 . VAL A 1 37  ? 8.759   26.439 88.924  1.00 17.66 ? 42  VAL H CG2 1 
ATOM   276  N  N   . ARG A 1 38  ? 7.195   30.658 90.213  1.00 16.08 ? 43  ARG H N   1 
ATOM   277  C  CA  . ARG A 1 38  ? 7.318   32.073 90.577  1.00 16.42 ? 43  ARG H CA  1 
ATOM   278  C  C   . ARG A 1 38  ? 7.794   32.246 92.014  1.00 16.98 ? 43  ARG H C   1 
ATOM   279  O  O   . ARG A 1 38  ? 7.653   31.356 92.827  1.00 16.76 ? 43  ARG H O   1 
ATOM   280  C  CB  . ARG A 1 38  ? 5.995   32.793 90.319  1.00 16.19 ? 43  ARG H CB  1 
ATOM   281  C  CG  . ARG A 1 38  ? 4.902   32.438 91.294  1.00 15.99 ? 43  ARG H CG  1 
ATOM   282  C  CD  . ARG A 1 38  ? 3.582   33.079 90.868  1.00 16.91 ? 43  ARG H CD  1 
ATOM   283  N  NE  . ARG A 1 38  ? 2.493   32.678 91.773  1.00 17.02 ? 43  ARG H NE  1 
ATOM   284  C  CZ  . ARG A 1 38  ? 1.242   33.075 91.635  1.00 18.71 ? 43  ARG H CZ  1 
ATOM   285  N  NH1 . ARG A 1 38  ? 0.908   33.907 90.652  1.00 17.84 ? 43  ARG H NH1 1 
ATOM   286  N  NH2 . ARG A 1 38  ? 0.326   32.630 92.480  1.00 21.48 ? 43  ARG H NH2 1 
ATOM   287  N  N   . GLN A 1 39  ? 8.293   33.440 92.300  1.00 16.52 ? 44  GLN H N   1 
ATOM   288  C  CA  . GLN A 1 39  ? 8.794   33.814 93.611  1.00 15.21 ? 44  GLN H CA  1 
ATOM   289  C  C   . GLN A 1 39  ? 8.430   35.268 93.920  1.00 14.65 ? 44  GLN H C   1 
ATOM   290  O  O   . GLN A 1 39  ? 8.983   36.190 93.333  1.00 16.61 ? 44  GLN H O   1 
ATOM   291  C  CB  . GLN A 1 39  ? 10.293  33.581 93.626  1.00 16.12 ? 44  GLN H CB  1 
ATOM   292  C  CG  . GLN A 1 39  ? 10.916  33.899 94.992  1.00 15.83 ? 44  GLN H CG  1 
ATOM   293  C  CD  . GLN A 1 39  ? 12.331  33.370 94.963  1.00 17.75 ? 44  GLN H CD  1 
ATOM   294  O  OE1 . GLN A 1 39  ? 13.078  33.589 94.017  1.00 19.19 ? 44  GLN H OE1 1 
ATOM   295  N  NE2 . GLN A 1 39  ? 12.669  32.614 95.989  1.00 17.83 ? 44  GLN H NE2 1 
ATOM   296  N  N   . ALA A 1 40  ? 7.507   35.403 94.860  1.00 15.67 ? 45  ALA H N   1 
ATOM   297  C  CA  . ALA A 1 40  ? 7.085   36.708 95.337  1.00 17.77 ? 45  ALA H CA  1 
ATOM   298  C  C   . ALA A 1 40  ? 8.258   37.314 96.077  1.00 20.14 ? 45  ALA H C   1 
ATOM   299  O  O   . ALA A 1 40  ? 9.105   36.593 96.615  1.00 19.43 ? 45  ALA H O   1 
ATOM   300  C  CB  . ALA A 1 40  ? 5.861   36.567 96.194  1.00 18.46 ? 45  ALA H CB  1 
ATOM   301  N  N   . PRO A 1 41  ? 8.356   38.651 96.122  1.00 22.14 ? 46  PRO H N   1 
ATOM   302  C  CA  . PRO A 1 41  ? 9.486   39.277 96.799  1.00 25.83 ? 46  PRO H CA  1 
ATOM   303  C  C   . PRO A 1 41  ? 9.642   38.808 98.252  1.00 22.57 ? 46  PRO H C   1 
ATOM   304  O  O   . PRO A 1 41  ? 8.688   38.769 99.021  1.00 24.40 ? 46  PRO H O   1 
ATOM   305  C  CB  . PRO A 1 41  ? 9.115   40.767 96.707  1.00 24.85 ? 46  PRO H CB  1 
ATOM   306  C  CG  . PRO A 1 41  ? 8.355   40.887 95.431  1.00 26.34 ? 46  PRO H CG  1 
ATOM   307  C  CD  . PRO A 1 41  ? 7.480   39.641 95.435  1.00 21.71 ? 46  PRO H CD  1 
ATOM   308  N  N   . GLY A 1 42  ? 10.839  38.337 98.567  1.00 26.22 ? 47  GLY H N   1 
ATOM   309  C  CA  . GLY A 1 42  ? 11.169  37.852 99.898  1.00 26.17 ? 47  GLY H CA  1 
ATOM   310  C  C   . GLY A 1 42  ? 10.567  36.492 100.267 1.00 28.48 ? 47  GLY H C   1 
ATOM   311  O  O   . GLY A 1 42  ? 10.635  36.068 101.419 1.00 26.29 ? 47  GLY H O   1 
ATOM   312  N  N   . LYS A 1 43  ? 9.951   35.774 99.310  1.00 21.56 ? 48  LYS H N   1 
ATOM   313  C  CA  . LYS A 1 43  ? 9.243   34.545 99.610  1.00 20.55 ? 48  LYS H CA  1 
ATOM   314  C  C   . LYS A 1 43  ? 9.917   33.376 98.881  1.00 16.21 ? 48  LYS H C   1 
ATOM   315  O  O   . LYS A 1 43  ? 10.946  33.525 98.249  1.00 18.19 ? 48  LYS H O   1 
ATOM   316  C  CB  . LYS A 1 43  ? 7.765   34.618 99.199  1.00 22.80 ? 48  LYS H CB  1 
ATOM   317  C  CG  . LYS A 1 43  ? 6.941   35.745 99.826  1.00 27.89 ? 48  LYS H CG  1 
ATOM   318  C  CD  . LYS A 1 43  ? 6.808   35.642 101.310 1.00 36.70 ? 48  LYS H CD  1 
ATOM   319  C  CE  . LYS A 1 43  ? 5.740   36.596 101.821 1.00 46.26 ? 48  LYS H CE  1 
ATOM   320  N  NZ  . LYS A 1 43  ? 5.600   36.499 103.295 1.00 53.25 ? 48  LYS H NZ  1 
ATOM   321  N  N   . GLY A 1 44  ? 9.366   32.196 99.097  1.00 17.28 ? 49  GLY H N   1 
ATOM   322  C  CA  . GLY A 1 44  ? 9.934   30.980 98.516  1.00 15.61 ? 49  GLY H CA  1 
ATOM   323  C  C   . GLY A 1 44  ? 9.455   30.727 97.094  1.00 16.75 ? 49  GLY H C   1 
ATOM   324  O  O   . GLY A 1 44  ? 8.609   31.423 96.565  1.00 21.09 ? 49  GLY H O   1 
ATOM   325  N  N   . LEU A 1 45  ? 9.975   29.670 96.509  1.00 16.38 ? 50  LEU H N   1 
ATOM   326  C  CA  . LEU A 1 45  ? 9.518   29.233 95.198  1.00 16.00 ? 50  LEU H CA  1 
ATOM   327  C  C   . LEU A 1 45  ? 8.127   28.640 95.278  1.00 15.76 ? 50  LEU H C   1 
ATOM   328  O  O   . LEU A 1 45  ? 7.806   27.858 96.185  1.00 16.03 ? 50  LEU H O   1 
ATOM   329  C  CB  . LEU A 1 45  ? 10.518  28.214 94.641  1.00 15.55 ? 50  LEU H CB  1 
ATOM   330  C  CG  . LEU A 1 45  ? 11.959  28.709 94.502  1.00 16.85 ? 50  LEU H CG  1 
ATOM   331  C  CD1 . LEU A 1 45  ? 12.899  27.616 94.046  1.00 16.94 ? 50  LEU H CD1 1 
ATOM   332  C  CD2 . LEU A 1 45  ? 12.066  29.862 93.510  1.00 18.16 ? 50  LEU H CD2 1 
ATOM   333  N  N   . GLU A 1 46  ? 7.331   28.943 94.225  1.00 15.42 ? 51  GLU H N   1 
ATOM   334  C  CA  . GLU A 1 46  ? 5.969   28.457 94.134  1.00 15.85 ? 51  GLU H CA  1 
ATOM   335  C  C   . GLU A 1 46  ? 5.751   27.930 92.721  1.00 14.82 ? 51  GLU H C   1 
ATOM   336  O  O   . GLU A 1 46  ? 5.844   28.680 91.738  1.00 16.12 ? 51  GLU H O   1 
ATOM   337  C  CB  . GLU A 1 46  ? 4.905   29.510 94.453  1.00 18.78 ? 51  GLU H CB  1 
ATOM   338  C  CG  . GLU A 1 46  ? 3.503   28.944 94.261  1.00 21.91 ? 51  GLU H CG  1 
ATOM   339  C  CD  . GLU A 1 46  ? 2.355   29.887 94.587  1.00 26.83 ? 51  GLU H CD  1 
ATOM   340  O  OE1 . GLU A 1 46  ? 2.392   31.059 94.100  1.00 25.21 ? 51  GLU H OE1 1 
ATOM   341  O  OE2 . GLU A 1 46  ? 1.407   29.440 95.298  1.00 28.01 ? 51  GLU H OE2 1 
ATOM   342  N  N   . TRP A 1 47  ? 5.461   26.637 92.596  1.00 14.59 ? 52  TRP H N   1 
ATOM   343  C  CA  . TRP A 1 47  ? 5.117   26.068 91.300  1.00 17.06 ? 52  TRP H CA  1 
ATOM   344  C  C   . TRP A 1 47  ? 3.765   26.607 90.814  1.00 16.45 ? 52  TRP H C   1 
ATOM   345  O  O   . TRP A 1 47  ? 2.810   26.707 91.594  1.00 18.14 ? 52  TRP H O   1 
ATOM   346  C  CB  . TRP A 1 47  ? 5.124   24.538 91.401  1.00 16.59 ? 52  TRP H CB  1 
ATOM   347  C  CG  . TRP A 1 47  ? 4.702   23.805 90.173  1.00 16.74 ? 52  TRP H CG  1 
ATOM   348  C  CD1 . TRP A 1 47  ? 5.541   23.260 89.249  1.00 17.84 ? 52  TRP H CD1 1 
ATOM   349  C  CD2 . TRP A 1 47  ? 3.361   23.430 89.806  1.00 18.30 ? 52  TRP H CD2 1 
ATOM   350  N  NE1 . TRP A 1 47  ? 4.800   22.593 88.288  1.00 16.92 ? 52  TRP H NE1 1 
ATOM   351  C  CE2 . TRP A 1 47  ? 3.474   22.677 88.631  1.00 17.70 ? 52  TRP H CE2 1 
ATOM   352  C  CE3 . TRP A 1 47  ? 2.092   23.680 90.336  1.00 17.70 ? 52  TRP H CE3 1 
ATOM   353  C  CZ2 . TRP A 1 47  ? 2.348   22.156 87.996  1.00 18.39 ? 52  TRP H CZ2 1 
ATOM   354  C  CZ3 . TRP A 1 47  ? 0.985   23.150 89.716  1.00 19.91 ? 52  TRP H CZ3 1 
ATOM   355  C  CH2 . TRP A 1 47  ? 1.129   22.370 88.567  1.00 17.56 ? 52  TRP H CH2 1 
ATOM   356  N  N   . VAL A 1 48  ? 3.708   26.993 89.514  1.00 17.48 ? 53  VAL H N   1 
ATOM   357  C  CA  . VAL A 1 48  ? 2.529   27.632 88.935  1.00 17.25 ? 53  VAL H CA  1 
ATOM   358  C  C   . VAL A 1 48  ? 1.793   26.694 87.955  1.00 15.56 ? 53  VAL H C   1 
ATOM   359  O  O   . VAL A 1 48  ? 0.592   26.566 88.027  1.00 16.44 ? 53  VAL H O   1 
ATOM   360  C  CB  . VAL A 1 48  ? 2.932   28.923 88.215  1.00 18.13 ? 53  VAL H CB  1 
ATOM   361  C  CG1 . VAL A 1 48  ? 1.727   29.554 87.539  1.00 19.24 ? 53  VAL H CG1 1 
ATOM   362  C  CG2 . VAL A 1 48  ? 3.559   29.955 89.138  1.00 19.46 ? 53  VAL H CG2 1 
ATOM   363  N  N   . ALA A 1 49  ? 2.539   26.123 87.030  1.00 16.72 ? 54  ALA H N   1 
ATOM   364  C  CA  . ALA A 1 49  ? 1.943   25.284 85.991  1.00 15.80 ? 54  ALA H CA  1 
ATOM   365  C  C   . ALA A 1 49  ? 2.992   24.437 85.301  1.00 15.22 ? 54  ALA H C   1 
ATOM   366  O  O   . ALA A 1 49  ? 4.182   24.733 85.261  1.00 16.94 ? 54  ALA H O   1 
ATOM   367  C  CB  . ALA A 1 49  ? 1.263   26.186 84.979  1.00 18.08 ? 54  ALA H CB  1 
ATOM   368  N  N   . ASN A 1 50  ? 2.524   23.380 84.649  1.00 16.06 ? 55  ASN H N   1 
ATOM   369  C  CA  . ASN A 1 50  ? 3.415   22.578 83.822  1.00 15.07 ? 55  ASN H CA  1 
ATOM   370  C  C   . ASN A 1 50  ? 2.650   21.992 82.635  1.00 16.81 ? 55  ASN H C   1 
ATOM   371  O  O   . ASN A 1 50  ? 1.428   22.097 82.579  1.00 16.92 ? 55  ASN H O   1 
ATOM   372  C  CB  . ASN A 1 50  ? 4.156   21.481 84.600  1.00 16.38 ? 55  ASN H CB  1 
ATOM   373  C  CG  . ASN A 1 50  ? 3.319   20.332 85.100  1.00 17.88 ? 55  ASN H CG  1 
ATOM   374  O  OD1 . ASN A 1 50  ? 2.112   20.264 84.901  1.00 19.98 ? 55  ASN H OD1 1 
ATOM   375  N  ND2 . ASN A 1 50  ? 3.958   19.455 85.861  1.00 18.97 ? 55  ASN H ND2 1 
ATOM   376  N  N   . ILE A 1 51  ? 3.441   21.429 81.737  1.00 16.75 ? 56  ILE H N   1 
ATOM   377  C  CA  . ILE A 1 51  ? 2.950   20.912 80.456  1.00 16.05 ? 56  ILE H CA  1 
ATOM   378  C  C   . ILE A 1 51  ? 3.788   19.753 79.941  1.00 16.13 ? 56  ILE H C   1 
ATOM   379  O  O   . ILE A 1 51  ? 5.028   19.801 79.962  1.00 17.71 ? 56  ILE H O   1 
ATOM   380  C  CB  . ILE A 1 51  ? 2.899   22.089 79.464  1.00 17.33 ? 56  ILE H CB  1 
ATOM   381  C  CG1 . ILE A 1 51  ? 2.221   21.685 78.138  1.00 17.49 ? 56  ILE H CG1 1 
ATOM   382  C  CG2 . ILE A 1 51  ? 4.262   22.680 79.181  1.00 16.33 ? 56  ILE H CG2 1 
ATOM   383  C  CD1 . ILE A 1 51  ? 1.897   22.909 77.263  1.00 18.97 ? 56  ILE H CD1 1 
ATOM   384  N  N   . LYS A 1 52  ? 3.067   18.726 79.423  1.00 16.44 ? 57  LYS H N   1 
ATOM   385  C  CA  . LYS A 1 52  ? 3.706   17.560 78.835  1.00 18.59 ? 57  LYS H CA  1 
ATOM   386  C  C   . LYS A 1 52  ? 4.517   17.949 77.600  1.00 16.81 ? 57  LYS H C   1 
ATOM   387  O  O   . LYS A 1 52  ? 4.278   18.947 76.925  1.00 18.74 ? 57  LYS H O   1 
ATOM   388  C  CB  . LYS A 1 52  ? 2.579   16.558 78.608  1.00 20.91 ? 57  LYS H CB  1 
ATOM   389  C  CG  . LYS A 1 52  ? 3.013   15.187 78.087  1.00 24.90 ? 57  LYS H CG  1 
ATOM   390  C  CD  . LYS A 1 52  ? 1.872   14.234 78.312  1.00 26.07 ? 57  LYS H CD  1 
ATOM   391  C  CE  . LYS A 1 52  ? 1.939   12.990 77.455  1.00 32.22 ? 57  LYS H CE  1 
ATOM   392  N  NZ  . LYS A 1 52  ? 3.163   12.236 77.739  1.00 38.56 ? 57  LYS H NZ  1 
ATOM   393  N  N   . GLU A 1 53  ? 5.405   17.060 77.191  1.00 20.08 ? 58  GLU H N   1 
ATOM   394  C  CA  . GLU A 1 53  ? 6.327   17.338 76.097  1.00 19.25 ? 58  GLU H CA  1 
ATOM   395  C  C   . GLU A 1 53  ? 5.560   17.670 74.802  1.00 21.17 ? 58  GLU H C   1 
ATOM   396  O  O   . GLU A 1 53  ? 5.992   18.525 74.047  1.00 22.17 ? 58  GLU H O   1 
ATOM   397  C  CB  . GLU A 1 53  ? 7.352   16.204 76.012  1.00 23.59 ? 58  GLU H CB  1 
ATOM   398  C  CG  . GLU A 1 53  ? 6.800   14.899 75.469  1.00 26.16 ? 58  GLU H CG  1 
ATOM   399  C  CD  . GLU A 1 53  ? 6.067   14.063 76.504  1.00 29.80 ? 58  GLU H CD  1 
ATOM   400  O  OE1 . GLU A 1 53  ? 5.229   13.253 76.088  1.00 40.45 ? 58  GLU H OE1 1 
ATOM   401  O  OE2 . GLU A 1 53  ? 6.295   14.234 77.722  1.00 27.30 ? 58  GLU H OE2 1 
ATOM   402  N  N   . ASP A 1 54  ? 4.396   17.036 74.578  1.00 19.19 ? 59  ASP H N   1 
ATOM   403  C  CA  . ASP A 1 54  ? 3.585   17.249 73.382  1.00 20.91 ? 59  ASP H CA  1 
ATOM   404  C  C   . ASP A 1 54  ? 2.427   18.219 73.602  1.00 20.12 ? 59  ASP H C   1 
ATOM   405  O  O   . ASP A 1 54  ? 1.552   18.373 72.712  1.00 21.89 ? 59  ASP H O   1 
ATOM   406  C  CB  . ASP A 1 54  ? 3.021   15.924 72.848  1.00 21.46 ? 59  ASP H CB  1 
ATOM   407  C  CG  . ASP A 1 54  ? 2.021   15.222 73.753  1.00 25.53 ? 59  ASP H CG  1 
ATOM   408  O  OD1 . ASP A 1 54  ? 1.731   15.699 74.868  1.00 21.74 ? 59  ASP H OD1 1 
ATOM   409  O  OD2 . ASP A 1 54  ? 1.511   14.128 73.333  1.00 27.07 ? 59  ASP H OD2 1 
ATOM   410  N  N   . GLY A 1 55  ? 2.384   18.892 74.776  1.00 17.92 ? 62  GLY H N   1 
ATOM   411  C  CA  . GLY A 1 55  ? 1.307   19.824 75.053  1.00 16.23 ? 62  GLY H CA  1 
ATOM   412  C  C   . GLY A 1 55  ? 0.000   19.233 75.523  1.00 16.67 ? 62  GLY H C   1 
ATOM   413  O  O   . GLY A 1 55  ? -0.898  19.998 75.883  1.00 16.89 ? 62  GLY H O   1 
ATOM   414  N  N   . SER A 1 56  ? -0.155  17.881 75.540  1.00 18.10 ? 63  SER H N   1 
ATOM   415  C  CA  . SER A 1 56  ? -1.470  17.272 75.645  1.00 18.63 ? 63  SER H CA  1 
ATOM   416  C  C   . SER A 1 56  ? -2.018  17.116 77.065  1.00 21.73 ? 63  SER H C   1 
ATOM   417  O  O   . SER A 1 56  ? -3.189  16.734 77.212  1.00 23.04 ? 63  SER H O   1 
ATOM   418  C  CB  . SER A 1 56  ? -1.466  15.905 74.974  1.00 20.73 ? 63  SER H CB  1 
ATOM   419  O  OG  . SER A 1 56  ? -0.619  15.004 75.696  1.00 22.68 ? 63  SER H OG  1 
ATOM   420  N  N   . GLU A 1 57  ? -1.162  17.350 78.091  1.00 18.30 ? 64  GLU H N   1 
ATOM   421  C  CA  . GLU A 1 57  ? -1.546  17.353 79.498  1.00 20.18 ? 64  GLU H CA  1 
ATOM   422  C  C   . GLU A 1 57  ? -0.895  18.611 80.089  1.00 18.65 ? 64  GLU H C   1 
ATOM   423  O  O   . GLU A 1 57  ? 0.225   18.942 79.739  1.00 20.07 ? 64  GLU H O   1 
ATOM   424  C  CB  . GLU A 1 57  ? -1.002  16.039 80.081  1.00 26.55 ? 64  GLU H CB  1 
ATOM   425  C  CG  . GLU A 1 57  ? -1.421  15.584 81.454  1.00 32.91 ? 64  GLU H CG  1 
ATOM   426  C  CD  . GLU A 1 57  ? -0.906  14.179 81.820  1.00 31.72 ? 64  GLU H CD  1 
ATOM   427  O  OE1 . GLU A 1 57  ? -0.439  13.484 80.916  1.00 41.91 ? 64  GLU H OE1 1 
ATOM   428  O  OE2 . GLU A 1 57  ? -0.959  13.773 83.022  1.00 40.01 ? 64  GLU H OE2 1 
ATOM   429  N  N   . LYS A 1 58  ? -1.662  19.340 80.875  1.00 21.04 ? 65  LYS H N   1 
ATOM   430  C  CA  . LYS A 1 58  ? -1.110  20.431 81.667  1.00 20.89 ? 65  LYS H CA  1 
ATOM   431  C  C   . LYS A 1 58  ? -1.843  20.550 82.988  1.00 21.37 ? 65  LYS H C   1 
ATOM   432  O  O   . LYS A 1 58  ? -3.020  20.249 83.108  1.00 21.07 ? 65  LYS H O   1 
ATOM   433  C  CB  . LYS A 1 58  ? -1.253  21.716 80.887  1.00 26.74 ? 65  LYS H CB  1 
ATOM   434  C  CG  . LYS A 1 58  ? -2.635  22.098 80.460  1.00 31.15 ? 65  LYS H CG  1 
ATOM   435  C  CD  . LYS A 1 58  ? -2.604  22.687 79.063  1.00 36.92 ? 65  LYS H CD  1 
ATOM   436  C  CE  . LYS A 1 58  ? -2.349  21.600 78.051  1.00 41.51 ? 65  LYS H CE  1 
ATOM   437  N  NZ  . LYS A 1 58  ? -2.973  21.915 76.748  1.00 42.47 ? 65  LYS H NZ  1 
ATOM   438  N  N   . TYR A 1 59  ? -1.106  21.091 83.984  1.00 18.11 ? 66  TYR H N   1 
ATOM   439  C  CA  . TYR A 1 59  ? -1.653  21.236 85.319  1.00 18.91 ? 66  TYR H CA  1 
ATOM   440  C  C   . TYR A 1 59  ? -1.331  22.642 85.822  1.00 17.51 ? 66  TYR H C   1 
ATOM   441  O  O   . TYR A 1 59  ? -0.350  23.237 85.379  1.00 17.34 ? 66  TYR H O   1 
ATOM   442  C  CB  . TYR A 1 59  ? -1.041  20.177 86.251  1.00 18.36 ? 66  TYR H CB  1 
ATOM   443  C  CG  . TYR A 1 59  ? -1.405  18.794 85.782  1.00 23.06 ? 66  TYR H CG  1 
ATOM   444  C  CD1 . TYR A 1 59  ? -2.631  18.247 86.086  1.00 27.94 ? 66  TYR H CD1 1 
ATOM   445  C  CD2 . TYR A 1 59  ? -0.555  18.101 84.967  1.00 22.63 ? 66  TYR H CD2 1 
ATOM   446  C  CE1 . TYR A 1 59  ? -2.997  17.008 85.591  1.00 32.52 ? 66  TYR H CE1 1 
ATOM   447  C  CE2 . TYR A 1 59  ? -0.885  16.837 84.498  1.00 25.36 ? 66  TYR H CE2 1 
ATOM   448  C  CZ  . TYR A 1 59  ? -2.114  16.302 84.795  1.00 32.10 ? 66  TYR H CZ  1 
ATOM   449  O  OH  . TYR A 1 59  ? -2.394  15.071 84.229  1.00 36.30 ? 66  TYR H OH  1 
ATOM   450  N  N   . TYR A 1 60  ? -2.170  23.117 86.742  1.00 17.44 ? 67  TYR H N   1 
ATOM   451  C  CA  . TYR A 1 60  ? -2.061  24.458 87.285  1.00 17.50 ? 67  TYR H CA  1 
ATOM   452  C  C   . TYR A 1 60  ? -2.274  24.431 88.808  1.00 19.37 ? 67  TYR H C   1 
ATOM   453  O  O   . TYR A 1 60  ? -3.081  23.647 89.336  1.00 20.18 ? 67  TYR H O   1 
ATOM   454  C  CB  . TYR A 1 60  ? -3.144  25.338 86.686  1.00 18.83 ? 67  TYR H CB  1 
ATOM   455  C  CG  . TYR A 1 60  ? -3.059  25.495 85.195  1.00 17.33 ? 67  TYR H CG  1 
ATOM   456  C  CD1 . TYR A 1 60  ? -2.244  26.449 84.636  1.00 17.45 ? 67  TYR H CD1 1 
ATOM   457  C  CD2 . TYR A 1 60  ? -3.761  24.649 84.340  1.00 17.20 ? 67  TYR H CD2 1 
ATOM   458  C  CE1 . TYR A 1 60  ? -2.158  26.606 83.260  1.00 16.13 ? 67  TYR H CE1 1 
ATOM   459  C  CE2 . TYR A 1 60  ? -3.691  24.813 82.976  1.00 16.66 ? 67  TYR H CE2 1 
ATOM   460  C  CZ  . TYR A 1 60  ? -2.869  25.770 82.424  1.00 17.34 ? 67  TYR H CZ  1 
ATOM   461  O  OH  . TYR A 1 60  ? -2.806  25.927 81.037  1.00 16.15 ? 67  TYR H OH  1 
ATOM   462  N  N   . VAL A 1 61  ? -1.683  25.417 89.486  1.00 23.39 ? 68  VAL H N   1 
ATOM   463  C  CA  . VAL A 1 61  ? -2.076  25.706 90.851  1.00 25.72 ? 68  VAL H CA  1 
ATOM   464  C  C   . VAL A 1 61  ? -3.504  26.273 90.836  1.00 28.25 ? 68  VAL H C   1 
ATOM   465  O  O   . VAL A 1 61  ? -3.916  26.948 89.889  1.00 24.36 ? 68  VAL H O   1 
ATOM   466  C  CB  . VAL A 1 61  ? -0.937  26.580 91.405  1.00 31.05 ? 68  VAL H CB  1 
ATOM   467  C  CG1 . VAL A 1 61  ? -1.080  28.035 90.948  1.00 27.65 ? 68  VAL H CG1 1 
ATOM   468  C  CG2 . VAL A 1 61  ? -0.775  26.465 92.888  1.00 33.90 ? 68  VAL H CG2 1 
ATOM   469  N  N   . ASP A 1 62  ? -4.345  25.988 91.845  1.00 26.27 ? 69  ASP H N   1 
ATOM   470  C  CA  . ASP A 1 62  ? -5.739  26.315 91.776  1.00 26.33 ? 69  ASP H CA  1 
ATOM   471  C  C   . ASP A 1 62  ? -5.984  27.816 91.651  1.00 21.78 ? 69  ASP H C   1 
ATOM   472  O  O   . ASP A 1 62  ? -6.976  28.247 91.072  1.00 25.44 ? 69  ASP H O   1 
ATOM   473  C  CB  A ASP A 1 62  ? -6.328  25.761 93.064  0.50 31.06 ? 69  ASP H CB  1 
ATOM   474  C  CB  B ASP A 1 62  ? -6.647  25.867 92.943  0.50 25.79 ? 69  ASP H CB  1 
ATOM   475  C  CG  A ASP A 1 62  ? -7.764  25.467 92.816  0.50 29.09 ? 69  ASP H CG  1 
ATOM   476  C  CG  B ASP A 1 62  ? -7.106  24.414 92.905  0.50 25.17 ? 69  ASP H CG  1 
ATOM   477  O  OD1 A ASP A 1 62  ? -8.500  26.438 92.758  0.50 34.40 ? 69  ASP H OD1 1 
ATOM   478  O  OD1 B ASP A 1 62  ? -7.581  23.941 91.835  0.50 18.75 ? 69  ASP H OD1 1 
ATOM   479  O  OD2 A ASP A 1 62  ? -8.068  24.271 92.557  0.50 32.78 ? 69  ASP H OD2 1 
ATOM   480  O  OD2 B ASP A 1 62  ? -7.012  23.778 93.966  0.50 24.69 ? 69  ASP H OD2 1 
ATOM   481  N  N   . SER A 1 63  ? -5.064  28.574 92.236  1.00 24.41 ? 70  SER H N   1 
ATOM   482  C  CA  . SER A 1 63  ? -5.172  30.032 92.292  1.00 24.22 ? 70  SER H CA  1 
ATOM   483  C  C   . SER A 1 63  ? -5.017  30.702 90.918  1.00 23.32 ? 70  SER H C   1 
ATOM   484  O  O   . SER A 1 63  ? -5.332  31.896 90.767  1.00 20.93 ? 70  SER H O   1 
ATOM   485  C  CB  . SER A 1 63  ? -4.152  30.581 93.255  1.00 22.88 ? 70  SER H CB  1 
ATOM   486  O  OG  . SER A 1 63  ? -2.818  30.354 92.837  1.00 24.82 ? 70  SER H OG  1 
ATOM   487  N  N   . VAL A 1 64  ? -4.617  29.924 89.901  1.00 19.04 ? 71  VAL H N   1 
ATOM   488  C  CA  . VAL A 1 64  ? -4.495  30.484 88.559  1.00 17.96 ? 71  VAL H CA  1 
ATOM   489  C  C   . VAL A 1 64  ? -5.371  29.773 87.540  1.00 18.28 ? 71  VAL H C   1 
ATOM   490  O  O   . VAL A 1 64  ? -5.394  30.181 86.386  1.00 18.51 ? 71  VAL H O   1 
ATOM   491  C  CB  . VAL A 1 64  ? -3.036  30.535 88.059  1.00 15.81 ? 71  VAL H CB  1 
ATOM   492  C  CG1 . VAL A 1 64  ? -2.160  31.231 89.064  1.00 17.18 ? 71  VAL H CG1 1 
ATOM   493  C  CG2 . VAL A 1 64  ? -2.480  29.166 87.700  1.00 17.62 ? 71  VAL H CG2 1 
ATOM   494  N  N   . LYS A 1 65  ? -6.077  28.691 87.921  1.00 17.31 ? 72  LYS H N   1 
ATOM   495  C  CA  . LYS A 1 65  ? -6.894  27.946 86.969  1.00 19.39 ? 72  LYS H CA  1 
ATOM   496  C  C   . LYS A 1 65  ? -7.960  28.821 86.334  1.00 18.97 ? 72  LYS H C   1 
ATOM   497  O  O   . LYS A 1 65  ? -8.646  29.589 86.999  1.00 21.79 ? 72  LYS H O   1 
ATOM   498  C  CB  . LYS A 1 65  ? -7.572  26.719 87.602  1.00 22.37 ? 72  LYS H CB  1 
ATOM   499  C  CG  . LYS A 1 65  ? -6.590  25.615 87.926  1.00 28.54 ? 72  LYS H CG  1 
ATOM   500  C  CD  . LYS A 1 65  ? -7.213  24.447 88.649  1.00 29.40 ? 72  LYS H CD  1 
ATOM   501  C  CE  . LYS A 1 65  ? -6.136  23.553 89.228  1.00 29.28 ? 72  LYS H CE  1 
ATOM   502  N  NZ  . LYS A 1 65  ? -6.675  22.451 90.031  1.00 33.89 ? 72  LYS H NZ  1 
ATOM   503  N  N   . GLY A 1 66  ? -8.046  28.712 85.010  1.00 16.91 ? 74  GLY H N   1 
ATOM   504  C  CA  . GLY A 1 66  ? -8.990  29.475 84.232  1.00 17.43 ? 74  GLY H CA  1 
ATOM   505  C  C   . GLY A 1 66  ? -8.486  30.860 83.837  1.00 16.71 ? 74  GLY H C   1 
ATOM   506  O  O   . GLY A 1 66  ? -9.146  31.493 83.014  1.00 18.15 ? 74  GLY H O   1 
ATOM   507  N  N   . ARG A 1 67  ? -7.375  31.341 84.404  1.00 17.48 ? 75  ARG H N   1 
ATOM   508  C  CA  . ARG A 1 67  ? -6.887  32.648 83.965  1.00 16.17 ? 75  ARG H CA  1 
ATOM   509  C  C   . ARG A 1 67  ? -5.421  32.642 83.502  1.00 14.56 ? 75  ARG H C   1 
ATOM   510  O  O   . ARG A 1 67  ? -4.980  33.636 82.887  1.00 15.58 ? 75  ARG H O   1 
ATOM   511  C  CB  . ARG A 1 67  ? -7.125  33.678 85.072  1.00 17.72 ? 75  ARG H CB  1 
ATOM   512  C  CG  . ARG A 1 67  ? -6.318  33.466 86.335  1.00 16.73 ? 75  ARG H CG  1 
ATOM   513  C  CD  . ARG A 1 67  ? -6.692  34.425 87.447  1.00 17.44 ? 75  ARG H CD  1 
ATOM   514  N  NE  . ARG A 1 67  ? -5.870  34.141 88.615  1.00 17.98 ? 75  ARG H NE  1 
ATOM   515  C  CZ  . ARG A 1 67  ? -4.843  34.894 89.010  1.00 16.69 ? 75  ARG H CZ  1 
ATOM   516  N  NH1 . ARG A 1 67  ? -4.532  35.994 88.349  1.00 16.76 ? 75  ARG H NH1 1 
ATOM   517  N  NH2 . ARG A 1 67  ? -4.087  34.506 90.023  1.00 18.19 ? 75  ARG H NH2 1 
ATOM   518  N  N   . PHE A 1 68  ? -4.690  31.586 83.833  1.00 14.76 ? 76  PHE H N   1 
ATOM   519  C  CA  . PHE A 1 68  ? -3.368  31.423 83.239  1.00 14.55 ? 76  PHE H CA  1 
ATOM   520  C  C   . PHE A 1 68  ? -3.420  30.240 82.298  1.00 16.23 ? 76  PHE H C   1 
ATOM   521  O  O   . PHE A 1 68  ? -4.028  29.228 82.661  1.00 15.29 ? 76  PHE H O   1 
ATOM   522  C  CB  . PHE A 1 68  ? -2.244  31.167 84.243  1.00 15.44 ? 76  PHE H CB  1 
ATOM   523  C  CG  . PHE A 1 68  ? -1.755  32.301 85.117  1.00 16.04 ? 76  PHE H CG  1 
ATOM   524  C  CD1 . PHE A 1 68  ? -2.456  33.476 85.259  1.00 15.54 ? 76  PHE H CD1 1 
ATOM   525  C  CD2 . PHE A 1 68  ? -0.607  32.149 85.890  1.00 15.91 ? 76  PHE H CD2 1 
ATOM   526  C  CE1 . PHE A 1 68  ? -2.057  34.480 86.121  1.00 15.72 ? 76  PHE H CE1 1 
ATOM   527  C  CE2 . PHE A 1 68  ? -0.197  33.170 86.743  1.00 16.69 ? 76  PHE H CE2 1 
ATOM   528  C  CZ  . PHE A 1 68  ? -0.926  34.317 86.874  1.00 15.44 ? 76  PHE H CZ  1 
ATOM   529  N  N   . THR A 1 69  ? -2.652  30.302 81.213  1.00 14.85 ? 77  THR H N   1 
ATOM   530  C  CA  . THR A 1 69  ? -2.567  29.159 80.289  1.00 14.58 ? 77  THR H CA  1 
ATOM   531  C  C   . THR A 1 69  ? -1.112  28.941 79.931  1.00 14.56 ? 77  THR H C   1 
ATOM   532  O  O   . THR A 1 69  ? -0.474  29.854 79.436  1.00 14.84 ? 77  THR H O   1 
ATOM   533  C  CB  . THR A 1 69  ? -3.391  29.371 79.022  1.00 16.25 ? 77  THR H CB  1 
ATOM   534  O  OG1 . THR A 1 69  ? -4.769  29.481 79.361  1.00 17.85 ? 77  THR H OG1 1 
ATOM   535  C  CG2 . THR A 1 69  ? -3.178  28.243 78.042  1.00 16.59 ? 77  THR H CG2 1 
ATOM   536  N  N   . ILE A 1 70  ? -0.625  27.718 80.155  1.00 15.40 ? 78  ILE H N   1 
ATOM   537  C  CA  . ILE A 1 70  ? 0.694   27.337 79.720  1.00 13.69 ? 78  ILE H CA  1 
ATOM   538  C  C   . ILE A 1 70  ? 0.565   26.685 78.343  1.00 14.26 ? 78  ILE H C   1 
ATOM   539  O  O   . ILE A 1 70  ? -0.396  25.943 78.117  1.00 16.26 ? 78  ILE H O   1 
ATOM   540  C  CB  . ILE A 1 70  ? 1.349   26.428 80.780  1.00 14.10 ? 78  ILE H CB  1 
ATOM   541  C  CG1 . ILE A 1 70  ? 2.811   26.175 80.439  1.00 14.86 ? 78  ILE H CG1 1 
ATOM   542  C  CG2 . ILE A 1 70  ? 0.539   25.173 80.993  1.00 14.75 ? 78  ILE H CG2 1 
ATOM   543  C  CD1 . ILE A 1 70  ? 3.583   25.413 81.537  1.00 15.01 ? 78  ILE H CD1 1 
ATOM   544  N  N   . SER A 1 71  ? 1.474   27.066 77.449  1.00 14.45 ? 79  SER H N   1 
ATOM   545  C  CA  . SER A 1 71  ? 1.551   26.426 76.141  1.00 15.59 ? 79  SER H CA  1 
ATOM   546  C  C   . SER A 1 71  ? 2.985   26.343 75.677  1.00 15.71 ? 79  SER H C   1 
ATOM   547  O  O   . SER A 1 71  ? 3.861   26.961 76.241  1.00 15.05 ? 79  SER H O   1 
ATOM   548  C  CB  . SER A 1 71  ? 0.734   27.184 75.107  1.00 14.43 ? 79  SER H CB  1 
ATOM   549  O  OG  . SER A 1 71  ? 1.102   28.544 74.987  1.00 15.59 ? 79  SER H OG  1 
ATOM   550  N  N   . ARG A 1 72  ? 3.196   25.610 74.574  1.00 16.26 ? 80  ARG H N   1 
ATOM   551  C  CA  . ARG A 1 72  ? 4.513   25.513 74.027  1.00 16.35 ? 80  ARG H CA  1 
ATOM   552  C  C   . ARG A 1 72  ? 4.433   25.478 72.504  1.00 15.77 ? 80  ARG H C   1 
ATOM   553  O  O   . ARG A 1 72  ? 3.410   25.051 71.939  1.00 17.49 ? 80  ARG H O   1 
ATOM   554  C  CB  . ARG A 1 72  ? 5.240   24.282 74.580  1.00 17.85 ? 80  ARG H CB  1 
ATOM   555  C  CG  . ARG A 1 72  ? 4.594   22.953 74.213  1.00 18.73 ? 80  ARG H CG  1 
ATOM   556  C  CD  . ARG A 1 72  ? 5.067   21.766 75.046  1.00 18.01 ? 80  ARG H CD  1 
ATOM   557  N  NE  . ARG A 1 72  ? 6.517   21.617 74.943  1.00 18.55 ? 80  ARG H NE  1 
ATOM   558  C  CZ  . ARG A 1 72  ? 7.277   21.025 75.873  1.00 16.91 ? 80  ARG H CZ  1 
ATOM   559  N  NH1 . ARG A 1 72  ? 6.759   20.572 76.980  1.00 16.91 ? 80  ARG H NH1 1 
ATOM   560  N  NH2 . ARG A 1 72  ? 8.557   20.876 75.634  1.00 17.92 ? 80  ARG H NH2 1 
ATOM   561  N  N   . ASP A 1 73  ? 5.551   25.868 71.903  1.00 16.77 ? 81  ASP H N   1 
ATOM   562  C  CA  . ASP A 1 73  ? 5.810   25.813 70.471  1.00 17.29 ? 81  ASP H CA  1 
ATOM   563  C  C   . ASP A 1 73  ? 7.096   25.009 70.277  1.00 18.90 ? 81  ASP H C   1 
ATOM   564  O  O   . ASP A 1 73  ? 8.181   25.597 70.378  1.00 19.66 ? 81  ASP H O   1 
ATOM   565  C  CB  . ASP A 1 73  ? 5.899   27.199 69.882  1.00 18.20 ? 81  ASP H CB  1 
ATOM   566  C  CG  . ASP A 1 73  ? 5.988   27.234 68.368  1.00 20.48 ? 81  ASP H CG  1 
ATOM   567  O  OD1 . ASP A 1 73  ? 6.406   26.174 67.816  1.00 20.74 ? 81  ASP H OD1 1 
ATOM   568  O  OD2 . ASP A 1 73  ? 5.484   28.243 67.753  1.00 20.89 ? 81  ASP H OD2 1 
ATOM   569  N  N   . ASN A 1 74  ? 6.936   23.697 70.048  1.00 18.85 ? 82  ASN H N   1 
ATOM   570  C  CA  . ASN A 1 74  ? 8.097   22.807 69.927  1.00 17.90 ? 82  ASN H CA  1 
ATOM   571  C  C   . ASN A 1 74  ? 8.913   23.172 68.696  1.00 20.76 ? 82  ASN H C   1 
ATOM   572  O  O   . ASN A 1 74  ? 10.147  23.128 68.720  1.00 22.16 ? 82  ASN H O   1 
ATOM   573  C  CB  . ASN A 1 74  ? 7.722   21.339 70.006  1.00 19.70 ? 82  ASN H CB  1 
ATOM   574  C  CG  . ASN A 1 74  ? 7.349   20.852 71.391  1.00 22.74 ? 82  ASN H CG  1 
ATOM   575  O  OD1 . ASN A 1 74  ? 7.618   21.527 72.395  1.00 20.64 ? 82  ASN H OD1 1 
ATOM   576  N  ND2 . ASN A 1 74  ? 6.712   19.701 71.470  1.00 24.96 ? 82  ASN H ND2 1 
ATOM   577  N  N   . ALA A 1 75  ? 8.257   23.697 67.658  1.00 20.10 ? 83  ALA H N   1 
ATOM   578  C  CA  . ALA A 1 75  ? 8.976   24.113 66.471  1.00 20.74 ? 83  ALA H CA  1 
ATOM   579  C  C   . ALA A 1 75  ? 9.938   25.250 66.735  1.00 23.51 ? 83  ALA H C   1 
ATOM   580  O  O   . ALA A 1 75  ? 10.992  25.315 66.121  1.00 28.51 ? 83  ALA H O   1 
ATOM   581  C  CB  . ALA A 1 75  ? 8.006   24.482 65.369  1.00 21.83 ? 83  ALA H CB  1 
ATOM   582  N  N   . LYS A 1 76  ? 9.576   26.190 67.616  1.00 19.92 ? 84  LYS H N   1 
ATOM   583  C  CA  . LYS A 1 76  ? 10.388  27.344 67.946  1.00 21.19 ? 84  LYS H CA  1 
ATOM   584  C  C   . LYS A 1 76  ? 11.151  27.131 69.273  1.00 18.72 ? 84  LYS H C   1 
ATOM   585  O  O   . LYS A 1 76  ? 11.697  28.109 69.789  1.00 22.27 ? 84  LYS H O   1 
ATOM   586  C  CB  . LYS A 1 76  ? 9.526   28.592 68.205  1.00 23.90 ? 84  LYS H CB  1 
ATOM   587  C  CG  . LYS A 1 76  ? 8.768   29.196 67.039  1.00 29.61 ? 84  LYS H CG  1 
ATOM   588  C  CD  . LYS A 1 76  ? 8.161   30.566 67.350  1.00 27.34 ? 84  LYS H CD  1 
ATOM   589  C  CE  . LYS A 1 76  ? 9.137   31.695 67.554  1.00 30.42 ? 84  LYS H CE  1 
ATOM   590  N  NZ  . LYS A 1 76  ? 8.474   33.030 67.535  1.00 34.90 ? 84  LYS H NZ  1 
ATOM   591  N  N   . ASN A 1 77  ? 11.086  25.927 69.849  1.00 18.43 ? 85  ASN H N   1 
ATOM   592  C  CA  . ASN A 1 77  ? 11.701  25.579 71.125  1.00 17.94 ? 85  ASN H CA  1 
ATOM   593  C  C   . ASN A 1 77  ? 11.317  26.603 72.199  1.00 19.45 ? 85  ASN H C   1 
ATOM   594  O  O   . ASN A 1 77  ? 12.182  27.172 72.836  1.00 19.19 ? 85  ASN H O   1 
ATOM   595  C  CB  . ASN A 1 77  ? 13.220  25.453 71.004  1.00 19.97 ? 85  ASN H CB  1 
ATOM   596  C  CG  . ASN A 1 77  ? 13.579  24.291 70.098  1.00 21.43 ? 85  ASN H CG  1 
ATOM   597  O  OD1 . ASN A 1 77  ? 12.946  23.238 70.139  1.00 24.23 ? 85  ASN H OD1 1 
ATOM   598  N  ND2 . ASN A 1 77  ? 14.649  24.454 69.355  1.00 28.30 ? 85  ASN H ND2 1 
ATOM   599  N  N   . SER A 1 78  ? 10.038  27.008 72.247  1.00 17.18 ? 86  SER H N   1 
ATOM   600  C  CA  . SER A 1 78  ? 9.587   28.058 73.164  1.00 16.20 ? 86  SER H CA  1 
ATOM   601  C  C   . SER A 1 78  ? 8.403   27.637 74.033  1.00 14.77 ? 86  SER H C   1 
ATOM   602  O  O   . SER A 1 78  ? 7.555   26.854 73.642  1.00 15.18 ? 86  SER H O   1 
ATOM   603  C  CB  . SER A 1 78  ? 9.271   29.298 72.412  1.00 16.97 ? 86  SER H CB  1 
ATOM   604  O  OG  . SER A 1 78  ? 10.428  29.822 71.741  1.00 20.72 ? 86  SER H OG  1 
ATOM   605  N  N   . LEU A 1 79  ? 8.424   28.170 75.260  1.00 14.70 ? 87  LEU H N   1 
ATOM   606  C  CA  . LEU A 1 79  ? 7.402   27.975 76.291  1.00 16.27 ? 87  LEU H CA  1 
ATOM   607  C  C   . LEU A 1 79  ? 6.732   29.316 76.542  1.00 15.13 ? 87  LEU H C   1 
ATOM   608  O  O   . LEU A 1 79  ? 7.410   30.350 76.508  1.00 14.80 ? 87  LEU H O   1 
ATOM   609  C  CB  . LEU A 1 79  ? 8.040   27.465 77.598  1.00 15.17 ? 87  LEU H CB  1 
ATOM   610  C  CG  . LEU A 1 79  ? 7.069   27.081 78.704  1.00 15.67 ? 87  LEU H CG  1 
ATOM   611  C  CD1 . LEU A 1 79  ? 6.250   25.832 78.366  1.00 17.29 ? 87  LEU H CD1 1 
ATOM   612  C  CD2 . LEU A 1 79  ? 7.825   26.922 80.022  1.00 16.85 ? 87  LEU H CD2 1 
ATOM   613  N  N   . TYR A 1 80  ? 5.433   29.296 76.880  1.00 14.36 ? 88  TYR H N   1 
ATOM   614  C  CA  . TYR A 1 80  ? 4.662   30.510 77.078  1.00 14.53 ? 88  TYR H CA  1 
ATOM   615  C  C   . TYR A 1 80  ? 3.791   30.390 78.319  1.00 13.72 ? 88  TYR H C   1 
ATOM   616  O  O   . TYR A 1 80  ? 3.334   29.301 78.679  1.00 14.18 ? 88  TYR H O   1 
ATOM   617  C  CB  . TYR A 1 80  ? 3.763   30.786 75.859  1.00 13.67 ? 88  TYR H CB  1 
ATOM   618  C  CG  . TYR A 1 80  ? 4.551   30.881 74.571  1.00 14.69 ? 88  TYR H CG  1 
ATOM   619  C  CD1 . TYR A 1 80  ? 5.085   32.081 74.163  1.00 13.72 ? 88  TYR H CD1 1 
ATOM   620  C  CD2 . TYR A 1 80  ? 4.783   29.752 73.798  1.00 16.41 ? 88  TYR H CD2 1 
ATOM   621  C  CE1 . TYR A 1 80  ? 5.840   32.211 73.006  1.00 15.23 ? 88  TYR H CE1 1 
ATOM   622  C  CE2 . TYR A 1 80  ? 5.552   29.848 72.637  1.00 15.34 ? 88  TYR H CE2 1 
ATOM   623  C  CZ  . TYR A 1 80  ? 6.056   31.067 72.238  1.00 15.19 ? 88  TYR H CZ  1 
ATOM   624  O  OH  . TYR A 1 80  ? 6.802   31.136 71.077  1.00 18.17 ? 88  TYR H OH  1 
ATOM   625  N  N   . LEU A 1 81  ? 3.563   31.546 78.960  1.00 13.24 ? 89  LEU H N   1 
ATOM   626  C  CA  . LEU A 1 81  ? 2.552   31.665 79.997  1.00 14.59 ? 89  LEU H CA  1 
ATOM   627  C  C   . LEU A 1 81  ? 1.687   32.883 79.691  1.00 13.61 ? 89  LEU H C   1 
ATOM   628  O  O   . LEU A 1 81  ? 2.197   34.007 79.760  1.00 15.46 ? 89  LEU H O   1 
ATOM   629  C  CB  . LEU A 1 81  ? 3.174   31.752 81.400  1.00 14.98 ? 89  LEU H CB  1 
ATOM   630  C  CG  . LEU A 1 81  ? 2.160   31.628 82.557  1.00 15.23 ? 89  LEU H CG  1 
ATOM   631  C  CD1 . LEU A 1 81  ? 1.506   30.275 82.617  1.00 15.86 ? 89  LEU H CD1 1 
ATOM   632  C  CD2 . LEU A 1 81  ? 2.906   31.945 83.889  1.00 17.73 ? 89  LEU H CD2 1 
ATOM   633  N  N   . GLN A 1 82  ? 0.414   32.660 79.368  1.00 14.59 ? 90  GLN H N   1 
ATOM   634  C  CA  . GLN A 1 82  ? -0.499  33.751 79.131  1.00 15.00 ? 90  GLN H CA  1 
ATOM   635  C  C   . GLN A 1 82  ? -1.228  33.999 80.456  1.00 14.48 ? 90  GLN H C   1 
ATOM   636  O  O   . GLN A 1 82  ? -1.866  33.063 80.956  1.00 14.59 ? 90  GLN H O   1 
ATOM   637  C  CB  . GLN A 1 82  ? -1.521  33.339 78.059  1.00 13.40 ? 90  GLN H CB  1 
ATOM   638  C  CG  . GLN A 1 82  ? -2.560  34.376 77.722  1.00 13.65 ? 90  GLN H CG  1 
ATOM   639  C  CD  . GLN A 1 82  ? -1.916  35.709 77.493  1.00 13.02 ? 90  GLN H CD  1 
ATOM   640  O  OE1 . GLN A 1 82  ? -1.017  35.852 76.670  1.00 14.38 ? 90  GLN H OE1 1 
ATOM   641  N  NE2 . GLN A 1 82  ? -2.375  36.702 78.224  1.00 15.07 ? 90  GLN H NE2 1 
ATOM   642  N  N   . MET A 1 83  ? -1.086  35.217 81.008  1.00 14.81 ? 91  MET H N   1 
ATOM   643  C  CA  . MET A 1 83  ? -1.569  35.525 82.349  1.00 16.19 ? 91  MET H CA  1 
ATOM   644  C  C   . MET A 1 83  ? -2.629  36.615 82.261  1.00 16.22 ? 91  MET H C   1 
ATOM   645  O  O   . MET A 1 83  ? -2.366  37.715 81.752  1.00 14.98 ? 91  MET H O   1 
ATOM   646  C  CB  . MET A 1 83  ? -0.384  36.002 83.204  1.00 19.36 ? 91  MET H CB  1 
ATOM   647  C  CG  . MET A 1 83  ? 0.732   35.049 83.302  1.00 19.89 ? 91  MET H CG  1 
ATOM   648  S  SD  . MET A 1 83  ? 2.289   35.999 83.881  1.00 27.73 ? 91  MET H SD  1 
ATOM   649  C  CE  . MET A 1 83  ? 1.772   36.245 85.553  1.00 31.52 ? 91  MET H CE  1 
ATOM   650  N  N   . ASN A 1 84  ? -3.836  36.333 82.793  1.00 14.69 ? 92  ASN H N   1 
ATOM   651  C  CA  . ASN A 1 84  ? -4.950  37.252 82.750  1.00 14.19 ? 92  ASN H CA  1 
ATOM   652  C  C   . ASN A 1 84  ? -5.492  37.534 84.164  1.00 13.59 ? 92  ASN H C   1 
ATOM   653  O  O   . ASN A 1 84  ? -5.195  36.828 85.125  1.00 15.82 ? 92  ASN H O   1 
ATOM   654  C  CB  . ASN A 1 84  ? -6.024  36.753 81.763  1.00 15.92 ? 92  ASN H CB  1 
ATOM   655  C  CG  . ASN A 1 84  ? -5.573  36.911 80.329  1.00 15.78 ? 92  ASN H CG  1 
ATOM   656  O  OD1 . ASN A 1 84  ? -4.787  36.109 79.856  1.00 18.20 ? 92  ASN H OD1 1 
ATOM   657  N  ND2 . ASN A 1 84  ? -5.991  37.966 79.658  1.00 15.76 ? 92  ASN H ND2 1 
ATOM   658  N  N   . SER A 1 85  ? -6.301  38.586 84.257  1.00 15.88 ? 93  SER H N   1 
ATOM   659  C  CA  . SER A 1 85  ? -6.948  39.029 85.474  1.00 14.09 ? 93  SER H CA  1 
ATOM   660  C  C   . SER A 1 85  ? -5.935  39.161 86.618  1.00 14.74 ? 93  SER H C   1 
ATOM   661  O  O   . SER A 1 85  ? -6.119  38.610 87.673  1.00 15.94 ? 93  SER H O   1 
ATOM   662  C  CB  . SER A 1 85  ? -8.059  38.074 85.861  1.00 16.53 ? 93  SER H CB  1 
ATOM   663  O  OG  . SER A 1 85  ? -8.967  37.975 84.792  1.00 19.06 ? 93  SER H OG  1 
ATOM   664  N  N   . LEU A 1 86  ? -4.814  39.831 86.337  1.00 15.22 ? 94  LEU H N   1 
ATOM   665  C  CA  . LEU A 1 86  ? -3.716  39.856 87.276  1.00 16.37 ? 94  LEU H CA  1 
ATOM   666  C  C   . LEU A 1 86  ? -4.047  40.644 88.554  1.00 15.26 ? 94  LEU H C   1 
ATOM   667  O  O   . LEU A 1 86  ? -4.834  41.608 88.569  1.00 16.72 ? 94  LEU H O   1 
ATOM   668  C  CB  . LEU A 1 86  ? -2.492  40.412 86.544  1.00 16.29 ? 94  LEU H CB  1 
ATOM   669  C  CG  . LEU A 1 86  ? -1.828  39.403 85.597  1.00 15.84 ? 94  LEU H CG  1 
ATOM   670  C  CD1 . LEU A 1 86  ? -0.786  40.092 84.741  1.00 17.99 ? 94  LEU H CD1 1 
ATOM   671  C  CD2 . LEU A 1 86  ? -1.222  38.221 86.357  1.00 18.99 ? 94  LEU H CD2 1 
ATOM   672  N  N   . ARG A 1 87  ? -3.526  40.144 89.660  1.00 15.55 ? 95  ARG H N   1 
ATOM   673  C  CA  . ARG A 1 87  ? -3.722  40.681 90.991  1.00 18.16 ? 95  ARG H CA  1 
ATOM   674  C  C   . ARG A 1 87  ? -2.392  40.866 91.695  1.00 20.38 ? 95  ARG H C   1 
ATOM   675  O  O   . ARG A 1 87  ? -1.373  40.344 91.263  1.00 17.17 ? 95  ARG H O   1 
ATOM   676  C  CB  . ARG A 1 87  ? -4.562  39.699 91.777  1.00 21.36 ? 95  ARG H CB  1 
ATOM   677  C  CG  . ARG A 1 87  ? -5.997  39.603 91.306  1.00 22.12 ? 95  ARG H CG  1 
ATOM   678  C  CD  . ARG A 1 87  ? -6.652  38.496 92.093  1.00 24.00 ? 95  ARG H CD  1 
ATOM   679  N  NE  . ARG A 1 87  ? -6.859  38.923 93.472  1.00 22.61 ? 95  ARG H NE  1 
ATOM   680  C  CZ  . ARG A 1 87  ? -7.631  38.284 94.338  1.00 25.84 ? 95  ARG H CZ  1 
ATOM   681  N  NH1 . ARG A 1 87  ? -8.293  37.238 93.935  1.00 24.85 ? 95  ARG H NH1 1 
ATOM   682  N  NH2 . ARG A 1 87  ? -7.798  38.757 95.562  1.00 25.49 ? 95  ARG H NH2 1 
ATOM   683  N  N   . ALA A 1 88  ? -2.375  41.653 92.782  1.00 22.00 ? 96  ALA H N   1 
ATOM   684  C  CA  . ALA A 1 88  ? -1.116  41.842 93.489  1.00 22.75 ? 96  ALA H CA  1 
ATOM   685  C  C   . ALA A 1 88  ? -0.530  40.524 93.984  1.00 21.71 ? 96  ALA H C   1 
ATOM   686  O  O   . ALA A 1 88  ? 0.705   40.370 94.052  1.00 22.81 ? 96  ALA H O   1 
ATOM   687  C  CB  . ALA A 1 88  ? -1.302  42.849 94.615  1.00 24.79 ? 96  ALA H CB  1 
ATOM   688  N  N   . GLU A 1 89  ? -1.359  39.513 94.272  1.00 21.64 ? 97  GLU H N   1 
ATOM   689  C  CA  . GLU A 1 89  ? -0.902  38.178 94.677  1.00 24.86 ? 97  GLU H CA  1 
ATOM   690  C  C   . GLU A 1 89  ? -0.035  37.538 93.578  1.00 21.84 ? 97  GLU H C   1 
ATOM   691  O  O   . GLU A 1 89  ? 0.671   36.555 93.817  1.00 25.21 ? 97  GLU H O   1 
ATOM   692  C  CB  . GLU A 1 89  ? -2.068  37.266 95.125  1.00 27.26 ? 97  GLU H CB  1 
ATOM   693  C  CG  . GLU A 1 89  ? -2.992  36.719 94.016  1.00 29.37 ? 97  GLU H CG  1 
ATOM   694  C  CD  . GLU A 1 89  ? -4.191  35.831 94.397  1.00 28.89 ? 97  GLU H CD  1 
ATOM   695  O  OE1 . GLU A 1 89  ? -5.122  36.328 95.123  1.00 30.97 ? 97  GLU H OE1 1 
ATOM   696  O  OE2 . GLU A 1 89  ? -4.238  34.658 93.944  1.00 26.91 ? 97  GLU H OE2 1 
ATOM   697  N  N   . ASP A 1 90  ? -0.095  38.067 92.337  1.00 18.13 ? 98  ASP H N   1 
ATOM   698  C  CA  . ASP A 1 90  ? 0.645   37.515 91.221  1.00 16.48 ? 98  ASP H CA  1 
ATOM   699  C  C   . ASP A 1 90  ? 2.000   38.173 91.040  1.00 17.56 ? 98  ASP H C   1 
ATOM   700  O  O   . ASP A 1 90  ? 2.815   37.758 90.234  1.00 16.18 ? 98  ASP H O   1 
ATOM   701  C  CB  . ASP A 1 90  ? -0.150  37.627 89.917  1.00 15.52 ? 98  ASP H CB  1 
ATOM   702  C  CG  . ASP A 1 90  ? -1.460  36.887 89.984  1.00 17.38 ? 98  ASP H CG  1 
ATOM   703  O  OD1 . ASP A 1 90  ? -1.443  35.680 90.393  1.00 17.56 ? 98  ASP H OD1 1 
ATOM   704  O  OD2 . ASP A 1 90  ? -2.482  37.473 89.568  1.00 17.20 ? 98  ASP H OD2 1 
ATOM   705  N  N   . THR A 1 91  ? 2.276   39.245 91.804  1.00 16.17 ? 99  THR H N   1 
ATOM   706  C  CA  . THR A 1 91  ? 3.543   39.933 91.716  1.00 15.11 ? 99  THR H CA  1 
ATOM   707  C  C   . THR A 1 91  ? 4.680   39.005 92.137  1.00 16.34 ? 99  THR H C   1 
ATOM   708  O  O   . THR A 1 91  ? 4.596   38.377 93.169  1.00 19.13 ? 99  THR H O   1 
ATOM   709  C  CB  . THR A 1 91  ? 3.557   41.194 92.571  1.00 17.47 ? 99  THR H CB  1 
ATOM   710  O  OG1 . THR A 1 91  ? 2.720   42.220 92.004  1.00 16.45 ? 99  THR H OG1 1 
ATOM   711  C  CG2 . THR A 1 91  ? 4.954   41.731 92.737  1.00 17.81 ? 99  THR H CG2 1 
ATOM   712  N  N   . ALA A 1 92  ? 5.682   38.831 91.281  1.00 17.05 ? 100 ALA H N   1 
ATOM   713  C  CA  . ALA A 1 92  ? 6.692   37.814 91.509  1.00 14.94 ? 100 ALA H CA  1 
ATOM   714  C  C   . ALA A 1 92  ? 7.685   37.852 90.352  1.00 15.62 ? 100 ALA H C   1 
ATOM   715  O  O   . ALA A 1 92  ? 7.374   38.294 89.243  1.00 15.38 ? 100 ALA H O   1 
ATOM   716  C  CB  . ALA A 1 92  ? 6.100   36.401 91.604  1.00 14.55 ? 100 ALA H CB  1 
ATOM   717  N  N   . VAL A 1 93  ? 8.843   37.218 90.558  1.00 15.31 ? 101 VAL H N   1 
ATOM   718  C  CA  . VAL A 1 93  ? 9.731   36.848 89.480  1.00 16.27 ? 101 VAL H CA  1 
ATOM   719  C  C   . VAL A 1 93  ? 9.229   35.513 88.940  1.00 16.19 ? 101 VAL H C   1 
ATOM   720  O  O   . VAL A 1 93  ? 8.951   34.571 89.687  1.00 16.50 ? 101 VAL H O   1 
ATOM   721  C  CB  . VAL A 1 93  ? 11.198  36.744 89.952  1.00 17.34 ? 101 VAL H CB  1 
ATOM   722  C  CG1 . VAL A 1 93  ? 12.079  36.206 88.865  1.00 18.63 ? 101 VAL H CG1 1 
ATOM   723  C  CG2 . VAL A 1 93  ? 11.715  38.079 90.437  1.00 18.53 ? 101 VAL H CG2 1 
ATOM   724  N  N   . TYR A 1 94  ? 9.020   35.459 87.622  1.00 16.10 ? 102 TYR H N   1 
ATOM   725  C  CA  . TYR A 1 94  ? 8.584   34.228 86.977  1.00 15.16 ? 102 TYR H CA  1 
ATOM   726  C  C   . TYR A 1 94  ? 9.755   33.594 86.219  1.00 15.47 ? 102 TYR H C   1 
ATOM   727  O  O   . TYR A 1 94  ? 10.396  34.247 85.403  1.00 16.54 ? 102 TYR H O   1 
ATOM   728  C  CB  . TYR A 1 94  ? 7.433   34.544 86.007  1.00 15.10 ? 102 TYR H CB  1 
ATOM   729  C  CG  . TYR A 1 94  ? 6.131   34.823 86.695  1.00 14.87 ? 102 TYR H CG  1 
ATOM   730  C  CD1 . TYR A 1 94  ? 5.923   36.016 87.399  1.00 14.22 ? 102 TYR H CD1 1 
ATOM   731  C  CD2 . TYR A 1 94  ? 5.095   33.904 86.699  1.00 15.46 ? 102 TYR H CD2 1 
ATOM   732  C  CE1 . TYR A 1 94  ? 4.754   36.243 88.092  1.00 15.55 ? 102 TYR H CE1 1 
ATOM   733  C  CE2 . TYR A 1 94  ? 3.901   34.124 87.393  1.00 15.92 ? 102 TYR H CE2 1 
ATOM   734  C  CZ  . TYR A 1 94  ? 3.754   35.285 88.126  1.00 15.23 ? 102 TYR H CZ  1 
ATOM   735  O  OH  . TYR A 1 94  ? 2.574   35.521 88.803  1.00 15.83 ? 102 TYR H OH  1 
ATOM   736  N  N   . TYR A 1 95  ? 9.945   32.303 86.488  1.00 15.10 ? 103 TYR H N   1 
ATOM   737  C  CA  . TYR A 1 95  ? 10.942  31.490 85.847  1.00 16.44 ? 103 TYR H CA  1 
ATOM   738  C  C   . TYR A 1 95  ? 10.313  30.396 84.998  1.00 16.03 ? 103 TYR H C   1 
ATOM   739  O  O   . TYR A 1 95  ? 9.433   29.658 85.436  1.00 16.39 ? 103 TYR H O   1 
ATOM   740  C  CB  . TYR A 1 95  ? 11.817  30.787 86.889  1.00 16.89 ? 103 TYR H CB  1 
ATOM   741  C  CG  . TYR A 1 95  ? 12.538  31.701 87.859  1.00 16.50 ? 103 TYR H CG  1 
ATOM   742  C  CD1 . TYR A 1 95  ? 13.680  32.359 87.485  1.00 17.90 ? 103 TYR H CD1 1 
ATOM   743  C  CD2 . TYR A 1 95  ? 12.047  31.849 89.154  1.00 17.32 ? 103 TYR H CD2 1 
ATOM   744  C  CE1 . TYR A 1 95  ? 14.342  33.151 88.412  1.00 18.55 ? 103 TYR H CE1 1 
ATOM   745  C  CE2 . TYR A 1 95  ? 12.733  32.584 90.104  1.00 19.33 ? 103 TYR H CE2 1 
ATOM   746  C  CZ  . TYR A 1 95  ? 13.848  33.284 89.698  1.00 18.46 ? 103 TYR H CZ  1 
ATOM   747  O  OH  . TYR A 1 95  ? 14.528  34.073 90.641  1.00 22.63 ? 103 TYR H OH  1 
ATOM   748  N  N   A CYS A 1 96  ? 10.821  30.233 83.773  0.50 16.55 ? 104 CYS H N   1 
ATOM   749  N  N   B CYS A 1 96  ? 10.895  30.231 83.806  0.50 19.05 ? 104 CYS H N   1 
ATOM   750  C  CA  A CYS A 1 96  ? 10.558  28.987 83.077  0.50 15.93 ? 104 CYS H CA  1 
ATOM   751  C  CA  B CYS A 1 96  ? 10.709  29.075 82.946  0.50 20.56 ? 104 CYS H CA  1 
ATOM   752  C  C   A CYS A 1 96  ? 11.597  27.986 83.552  0.50 16.64 ? 104 CYS H C   1 
ATOM   753  C  C   B CYS A 1 96  ? 11.646  27.977 83.464  0.50 19.13 ? 104 CYS H C   1 
ATOM   754  O  O   A CYS A 1 96  ? 12.759  28.320 83.772  0.50 18.51 ? 104 CYS H O   1 
ATOM   755  O  O   B CYS A 1 96  ? 12.822  28.257 83.675  0.50 20.82 ? 104 CYS H O   1 
ATOM   756  C  CB  A CYS A 1 96  ? 10.586  29.148 81.572  0.50 15.91 ? 104 CYS H CB  1 
ATOM   757  C  CB  B CYS A 1 96  ? 10.968  29.624 81.545  0.50 24.92 ? 104 CYS H CB  1 
ATOM   758  S  SG  A CYS A 1 96  ? 12.108  29.931 80.994  0.50 14.32 ? 104 CYS H SG  1 
ATOM   759  S  SG  B CYS A 1 96  ? 11.299  28.443 80.218  0.50 31.36 ? 104 CYS H SG  1 
ATOM   760  N  N   . ALA A 1 97  ? 11.129  26.778 83.756  1.00 18.84 ? 105 ALA H N   1 
ATOM   761  C  CA  . ALA A 1 97  ? 11.871  25.744 84.484  1.00 17.55 ? 105 ALA H CA  1 
ATOM   762  C  C   . ALA A 1 97  ? 11.616  24.429 83.783  1.00 18.60 ? 105 ALA H C   1 
ATOM   763  O  O   . ALA A 1 97  ? 10.498  23.954 83.702  1.00 22.57 ? 105 ALA H O   1 
ATOM   764  C  CB  . ALA A 1 97  ? 11.405  25.674 85.923  1.00 20.55 ? 105 ALA H CB  1 
ATOM   765  N  N   . THR A 1 98  ? 12.684  23.777 83.362  1.00 18.07 ? 106 THR H N   1 
ATOM   766  C  CA  . THR A 1 98  ? 12.574  22.470 82.751  1.00 18.18 ? 106 THR H CA  1 
ATOM   767  C  C   . THR A 1 98  ? 12.322  21.389 83.803  1.00 20.71 ? 106 THR H C   1 
ATOM   768  O  O   . THR A 1 98  ? 12.806  21.482 84.924  1.00 19.24 ? 106 THR H O   1 
ATOM   769  C  CB  . THR A 1 98  ? 13.890  22.166 82.033  1.00 17.84 ? 106 THR H CB  1 
ATOM   770  O  OG1 . THR A 1 98  ? 14.276  23.310 81.259  1.00 18.55 ? 106 THR H OG1 1 
ATOM   771  C  CG2 . THR A 1 98  ? 13.840  20.917 81.189  1.00 20.75 ? 106 THR H CG2 1 
ATOM   772  N  N   . ASP A 1 99  ? 11.635  20.334 83.390  1.00 21.78 ? 107 ASP H N   1 
ATOM   773  C  CA  A ASP A 1 99  ? 11.497  19.097 84.146  0.50 21.76 ? 107 ASP H CA  1 
ATOM   774  C  CA  C ASP A 1 99  ? 11.427  19.170 84.232  0.50 22.53 ? 107 ASP H CA  1 
ATOM   775  C  C   A ASP A 1 99  ? 12.849  18.722 84.744  0.50 20.52 ? 107 ASP H C   1 
ATOM   776  C  C   B ASP A 1 99  ? 12.803  18.615 84.743  0.50 18.84 ? 107 ASP H C   1 
ATOM   777  O  O   A ASP A 1 99  ? 13.852  18.650 84.034  0.50 19.75 ? 107 ASP H O   1 
ATOM   778  O  O   B ASP A 1 99  ? 13.799  18.741 84.035  0.50 18.90 ? 107 ASP H O   1 
ATOM   779  C  CB  A ASP A 1 99  ? 10.924  18.042 83.196  0.50 24.89 ? 107 ASP H CB  1 
ATOM   780  C  CB  C ASP A 1 99  ? 11.058  17.932 83.419  0.50 25.35 ? 107 ASP H CB  1 
ATOM   781  C  CG  A ASP A 1 99  ? 11.026  16.586 83.622  0.50 27.73 ? 107 ASP H CG  1 
ATOM   782  C  CG  C ASP A 1 99  ? 10.673  16.764 84.316  0.50 24.27 ? 107 ASP H CG  1 
ATOM   783  O  OD1 A ASP A 1 99  ? 11.147  16.334 84.835  0.50 20.96 ? 107 ASP H OD1 1 
ATOM   784  O  OD1 C ASP A 1 99  ? 9.583   16.829 84.930  0.50 30.14 ? 107 ASP H OD1 1 
ATOM   785  O  OD2 A ASP A 1 99  ? 10.962  15.712 82.707  0.50 31.34 ? 107 ASP H OD2 1 
ATOM   786  O  OD2 C ASP A 1 99  ? 11.499  15.836 84.433  0.50 27.46 ? 107 ASP H OD2 1 
ATOM   787  N  N   . PRO A 1 100 ? 12.977  18.528 86.084  1.00 18.87 ? 108 PRO H N   1 
ATOM   788  C  CA  . PRO A 1 100 ? 14.286  18.204 86.644  1.00 19.90 ? 108 PRO H CA  1 
ATOM   789  C  C   . PRO A 1 100 ? 14.889  16.923 86.112  1.00 20.00 ? 108 PRO H C   1 
ATOM   790  O  O   . PRO A 1 100 ? 16.088  16.751 86.165  1.00 20.93 ? 108 PRO H O   1 
ATOM   791  C  CB  . PRO A 1 100 ? 14.008  18.027 88.148  1.00 23.07 ? 108 PRO H CB  1 
ATOM   792  C  CG  . PRO A 1 100 ? 12.662  18.539 88.400  1.00 20.40 ? 108 PRO H CG  1 
ATOM   793  C  CD  . PRO A 1 100 ? 11.926  18.676 87.096  1.00 20.91 ? 108 PRO H CD  1 
ATOM   794  N  N   . ASP A 1 101 ? 14.085  16.033 85.498  1.00 22.31 ? 109 ASP H N   1 
ATOM   795  C  CA  . ASP A 1 101 ? 14.618  14.853 84.855  1.00 24.05 ? 109 ASP H CA  1 
ATOM   796  C  C   A ASP A 1 101 ? 15.624  15.188 83.755  0.50 22.66 ? 109 ASP H C   1 
ATOM   797  C  C   B ASP A 1 101 ? 15.624  15.188 83.755  0.50 22.66 ? 109 ASP H C   1 
ATOM   798  O  O   A ASP A 1 101 ? 16.412  14.340 83.358  0.50 26.73 ? 109 ASP H O   1 
ATOM   799  O  O   B ASP A 1 101 ? 16.412  14.340 83.358  0.50 26.75 ? 109 ASP H O   1 
ATOM   800  C  CB  . ASP A 1 101 ? 13.449  14.034 84.316  1.00 29.15 ? 109 ASP H CB  1 
ATOM   801  C  CG  . ASP A 1 101 ? 13.798  12.620 83.922  1.00 41.94 ? 109 ASP H CG  1 
ATOM   802  O  OD1 . ASP A 1 101 ? 14.159  11.848 84.843  1.00 39.46 ? 109 ASP H OD1 1 
ATOM   803  O  OD2 . ASP A 1 101 ? 13.663  12.297 82.690  1.00 45.21 ? 109 ASP H OD2 1 
ATOM   804  N  N   . VAL A 1 102 ? 15.595  16.404 83.217  1.00 22.09 ? 110 VAL H N   1 
ATOM   805  C  CA  . VAL A 1 102 ? 16.594  16.792 82.235  1.00 20.91 ? 110 VAL H CA  1 
ATOM   806  C  C   . VAL A 1 102 ? 18.022  16.730 82.827  1.00 20.01 ? 110 VAL H C   1 
ATOM   807  O  O   . VAL A 1 102 ? 19.003  16.600 82.106  1.00 20.97 ? 110 VAL H O   1 
ATOM   808  C  CB  . VAL A 1 102 ? 16.294  18.194 81.672  1.00 22.42 ? 110 VAL H CB  1 
ATOM   809  C  CG1 . VAL A 1 102 ? 16.606  19.329 82.653  1.00 22.96 ? 110 VAL H CG1 1 
ATOM   810  C  CG2 . VAL A 1 102 ? 17.015  18.405 80.361  1.00 22.98 ? 110 VAL H CG2 1 
ATOM   811  N  N   . GLY A 1 103 ? 18.163  16.949 84.149  1.00 19.93 ? 113 GLY H N   1 
ATOM   812  C  CA  . GLY A 1 103 ? 19.439  16.766 84.820  1.00 19.15 ? 113 GLY H CA  1 
ATOM   813  C  C   . GLY A 1 103 ? 20.491  17.819 84.559  1.00 16.66 ? 113 GLY H C   1 
ATOM   814  O  O   . GLY A 1 103 ? 21.688  17.535 84.712  1.00 18.96 ? 113 GLY H O   1 
ATOM   815  N  N   . LEU A 1 104 ? 20.063  18.999 84.056  1.00 17.17 ? 114 LEU H N   1 
ATOM   816  C  CA  . LEU A 1 104 ? 20.957  20.095 83.735  1.00 17.20 ? 114 LEU H CA  1 
ATOM   817  C  C   . LEU A 1 104 ? 20.864  21.201 84.784  1.00 16.38 ? 114 LEU H C   1 
ATOM   818  O  O   . LEU A 1 104 ? 19.749  21.621 85.144  1.00 16.81 ? 114 LEU H O   1 
ATOM   819  C  CB  . LEU A 1 104 ? 20.543  20.642 82.352  1.00 19.03 ? 114 LEU H CB  1 
ATOM   820  C  CG  . LEU A 1 104 ? 20.465  19.621 81.232  1.00 19.88 ? 114 LEU H CG  1 
ATOM   821  C  CD1 . LEU A 1 104 ? 20.099  20.323 79.923  1.00 20.11 ? 114 LEU H CD1 1 
ATOM   822  C  CD2 . LEU A 1 104 ? 21.768  18.879 81.068  1.00 19.89 ? 114 LEU H CD2 1 
ATOM   823  N  N   . SER A 1 105 ? 22.005  21.637 85.319  1.00 16.98 ? 115 SER H N   1 
ATOM   824  C  CA  . SER A 1 105 ? 21.965  22.590 86.420  1.00 15.97 ? 115 SER H CA  1 
ATOM   825  C  C   . SER A 1 105 ? 21.368  23.921 85.994  1.00 17.93 ? 115 SER H C   1 
ATOM   826  O  O   . SER A 1 105 ? 20.627  24.533 86.763  1.00 20.41 ? 115 SER H O   1 
ATOM   827  C  CB  . SER A 1 105 ? 23.324  22.700 87.097  1.00 16.95 ? 115 SER H CB  1 
ATOM   828  O  OG  . SER A 1 105 ? 24.308  23.159 86.178  1.00 18.93 ? 115 SER H OG  1 
ATOM   829  N  N   . ASP A 1 106 ? 21.672  24.308 84.742  1.00 17.83 ? 116 ASP H N   1 
ATOM   830  C  CA  . ASP A 1 106 ? 21.358  25.602 84.187  1.00 20.34 ? 116 ASP H CA  1 
ATOM   831  C  C   . ASP A 1 106 ? 20.081  25.523 83.351  1.00 19.22 ? 116 ASP H C   1 
ATOM   832  O  O   . ASP A 1 106 ? 19.983  26.193 82.325  1.00 22.32 ? 116 ASP H O   1 
ATOM   833  C  CB  . ASP A 1 106 ? 22.555  26.053 83.341  1.00 22.96 ? 116 ASP H CB  1 
ATOM   834  C  CG  . ASP A 1 106 ? 23.092  25.060 82.306  1.00 29.26 ? 116 ASP H CG  1 
ATOM   835  O  OD1 . ASP A 1 106 ? 22.614  23.898 82.230  1.00 28.70 ? 116 ASP H OD1 1 
ATOM   836  O  OD2 . ASP A 1 106 ? 24.028  25.452 81.545  1.00 31.83 ? 116 ASP H OD2 1 
ATOM   837  N  N   . SER A 1 107 ? 19.061  24.842 83.865  1.00 18.76 ? 117 SER H N   1 
ATOM   838  C  CA  . SER A 1 107 ? 17.882  24.511 83.078  1.00 19.62 ? 117 SER H CA  1 
ATOM   839  C  C   . SER A 1 107 ? 16.663  25.417 83.386  1.00 18.57 ? 117 SER H C   1 
ATOM   840  O  O   . SER A 1 107 ? 15.538  25.024 83.044  1.00 16.88 ? 117 SER H O   1 
ATOM   841  C  CB  . SER A 1 107 ? 17.569  23.066 83.230  1.00 20.18 ? 117 SER H CB  1 
ATOM   842  O  OG  . SER A 1 107 ? 17.443  22.702 84.563  1.00 22.45 ? 117 SER H OG  1 
ATOM   843  N  N   . TRP A 1 108 ? 16.859  26.572 84.070  1.00 17.57 ? 118 TRP H N   1 
ATOM   844  C  CA  . TRP A 1 108 ? 15.831  27.574 84.295  1.00 16.44 ? 118 TRP H CA  1 
ATOM   845  C  C   . TRP A 1 108 ? 16.267  28.846 83.586  1.00 16.94 ? 118 TRP H C   1 
ATOM   846  O  O   . TRP A 1 108 ? 17.472  29.149 83.463  1.00 19.10 ? 118 TRP H O   1 
ATOM   847  C  CB  . TRP A 1 108 ? 15.613  27.849 85.789  1.00 16.45 ? 118 TRP H CB  1 
ATOM   848  C  CG  . TRP A 1 108 ? 15.020  26.766 86.627  1.00 15.12 ? 118 TRP H CG  1 
ATOM   849  C  CD1 . TRP A 1 108 ? 15.135  25.410 86.459  1.00 15.08 ? 118 TRP H CD1 1 
ATOM   850  C  CD2 . TRP A 1 108 ? 14.187  26.952 87.787  1.00 15.19 ? 118 TRP H CD2 1 
ATOM   851  N  NE1 . TRP A 1 108 ? 14.453  24.731 87.430  1.00 16.06 ? 118 TRP H NE1 1 
ATOM   852  C  CE2 . TRP A 1 108 ? 13.830  25.651 88.239  1.00 15.90 ? 118 TRP H CE2 1 
ATOM   853  C  CE3 . TRP A 1 108 ? 13.672  28.078 88.464  1.00 15.83 ? 118 TRP H CE3 1 
ATOM   854  C  CZ2 . TRP A 1 108 ? 13.024  25.456 89.360  1.00 17.28 ? 118 TRP H CZ2 1 
ATOM   855  C  CZ3 . TRP A 1 108 ? 12.878  27.863 89.555  1.00 16.91 ? 118 TRP H CZ3 1 
ATOM   856  C  CH2 . TRP A 1 108 ? 12.576  26.582 90.005  1.00 18.26 ? 118 TRP H CH2 1 
ATOM   857  N  N   . GLY A 1 109 ? 15.292  29.672 83.209  1.00 17.01 ? 119 GLY H N   1 
ATOM   858  C  CA  . GLY A 1 109 ? 15.576  30.972 82.639  1.00 18.85 ? 119 GLY H CA  1 
ATOM   859  C  C   . GLY A 1 109 ? 15.970  31.983 83.712  1.00 20.93 ? 119 GLY H C   1 
ATOM   860  O  O   . GLY A 1 109 ? 15.952  31.659 84.912  1.00 20.91 ? 119 GLY H O   1 
ATOM   861  N  N   . GLN A 1 110 ? 16.336  33.174 83.233  1.00 21.47 ? 120 GLN H N   1 
ATOM   862  C  CA  . GLN A 1 110 ? 16.914  34.231 84.040  1.00 21.07 ? 120 GLN H CA  1 
ATOM   863  C  C   . GLN A 1 110 ? 15.882  34.911 84.935  1.00 24.61 ? 120 GLN H C   1 
ATOM   864  O  O   . GLN A 1 110 ? 16.227  35.610 85.898  1.00 25.51 ? 120 GLN H O   1 
ATOM   865  C  CB  . GLN A 1 110 ? 17.611  35.267 83.156  1.00 22.19 ? 120 GLN H CB  1 
ATOM   866  C  CG  . GLN A 1 110 ? 16.737  36.396 82.606  1.00 23.57 ? 120 GLN H CG  1 
ATOM   867  C  CD  . GLN A 1 110 ? 15.905  36.063 81.386  1.00 24.64 ? 120 GLN H CD  1 
ATOM   868  O  OE1 . GLN A 1 110 ? 15.875  34.934 80.916  1.00 26.07 ? 120 GLN H OE1 1 
ATOM   869  N  NE2 . GLN A 1 110 ? 15.320  37.094 80.799  1.00 28.27 ? 120 GLN H NE2 1 
ATOM   870  N  N   . GLY A 1 111 ? 14.620  34.637 84.696  1.00 20.45 ? 121 GLY H N   1 
ATOM   871  C  CA  . GLY A 1 111 ? 13.581  35.266 85.501  1.00 19.38 ? 121 GLY H CA  1 
ATOM   872  C  C   . GLY A 1 111 ? 13.133  36.599 84.905  1.00 22.24 ? 121 GLY H C   1 
ATOM   873  O  O   . GLY A 1 111 ? 13.952  37.357 84.374  1.00 23.57 ? 121 GLY H O   1 
ATOM   874  N  N   . THR A 1 112 ? 11.827  36.873 84.964  1.00 19.08 ? 122 THR H N   1 
ATOM   875  C  CA  . THR A 1 112 ? 11.299  38.178 84.606  1.00 19.58 ? 122 THR H CA  1 
ATOM   876  C  C   . THR A 1 112 ? 10.387  38.629 85.735  1.00 19.05 ? 122 THR H C   1 
ATOM   877  O  O   . THR A 1 112 ? 9.507   37.883 86.178  1.00 18.13 ? 122 THR H O   1 
ATOM   878  C  CB  . THR A 1 112 ? 10.603  38.176 83.242  1.00 21.85 ? 122 THR H CB  1 
ATOM   879  O  OG1 . THR A 1 112 ? 10.186  39.538 83.013  1.00 24.80 ? 122 THR H OG1 1 
ATOM   880  C  CG2 . THR A 1 112 ? 9.433   37.222 83.142  1.00 22.89 ? 122 THR H CG2 1 
ATOM   881  N  N   . LEU A 1 113 ? 10.634  39.843 86.247  1.00 19.80 ? 123 LEU H N   1 
ATOM   882  C  CA  . LEU A 1 113 ? 9.794   40.389 87.300  1.00 17.63 ? 123 LEU H CA  1 
ATOM   883  C  C   . LEU A 1 113 ? 8.479   40.916 86.740  1.00 17.54 ? 123 LEU H C   1 
ATOM   884  O  O   . LEU A 1 113 ? 8.481   41.773 85.873  1.00 17.70 ? 123 LEU H O   1 
ATOM   885  C  CB  . LEU A 1 113 ? 10.501  41.516 88.049  1.00 19.84 ? 123 LEU H CB  1 
ATOM   886  C  CG  . LEU A 1 113 ? 9.700   42.097 89.211  1.00 19.29 ? 123 LEU H CG  1 
ATOM   887  C  CD1 . LEU A 1 113 ? 9.484   41.108 90.348  1.00 21.38 ? 123 LEU H CD1 1 
ATOM   888  C  CD2 . LEU A 1 113 ? 10.419  43.331 89.773  1.00 22.16 ? 123 LEU H CD2 1 
ATOM   889  N  N   . VAL A 1 114 ? 7.373   40.441 87.320  1.00 17.75 ? 124 VAL H N   1 
ATOM   890  C  CA  . VAL A 1 114 ? 6.037   40.897 87.027  1.00 16.22 ? 124 VAL H CA  1 
ATOM   891  C  C   . VAL A 1 114 ? 5.582   41.652 88.266  1.00 15.59 ? 124 VAL H C   1 
ATOM   892  O  O   . VAL A 1 114 ? 5.553   41.100 89.338  1.00 16.62 ? 124 VAL H O   1 
ATOM   893  C  CB  . VAL A 1 114 ? 5.093   39.723 86.734  1.00 17.31 ? 124 VAL H CB  1 
ATOM   894  C  CG1 . VAL A 1 114 ? 3.612   40.150 86.725  1.00 17.31 ? 124 VAL H CG1 1 
ATOM   895  C  CG2 . VAL A 1 114 ? 5.461   38.998 85.469  1.00 16.62 ? 124 VAL H CG2 1 
ATOM   896  N  N   . THR A 1 115 ? 5.336   42.961 88.081  1.00 16.53 ? 125 THR H N   1 
ATOM   897  C  CA  . THR A 1 115 ? 4.816   43.830 89.124  1.00 16.57 ? 125 THR H CA  1 
ATOM   898  C  C   . THR A 1 115 ? 3.407   44.295 88.769  1.00 16.96 ? 125 THR H C   1 
ATOM   899  O  O   . THR A 1 115 ? 3.222   45.000 87.803  1.00 16.63 ? 125 THR H O   1 
ATOM   900  C  CB  . THR A 1 115 ? 5.702   45.071 89.308  1.00 17.92 ? 125 THR H CB  1 
ATOM   901  O  OG1 . THR A 1 115 ? 7.023   44.633 89.599  1.00 18.00 ? 125 THR H OG1 1 
ATOM   902  C  CG2 . THR A 1 115 ? 5.268   45.937 90.466  1.00 16.82 ? 125 THR H CG2 1 
ATOM   903  N  N   . VAL A 1 116 ? 2.435   43.860 89.576  1.00 17.74 ? 126 VAL H N   1 
ATOM   904  C  CA  . VAL A 1 116 ? 1.029   44.171 89.360  1.00 18.41 ? 126 VAL H CA  1 
ATOM   905  C  C   . VAL A 1 116 ? 0.675   45.350 90.256  1.00 19.15 ? 126 VAL H C   1 
ATOM   906  O  O   . VAL A 1 116 ? 0.428   45.192 91.460  1.00 19.64 ? 126 VAL H O   1 
ATOM   907  C  CB  . VAL A 1 116 ? 0.129   42.959 89.646  1.00 17.53 ? 126 VAL H CB  1 
ATOM   908  C  CG1 . VAL A 1 116 ? -1.290  43.323 89.273  1.00 17.68 ? 126 VAL H CG1 1 
ATOM   909  C  CG2 . VAL A 1 116 ? 0.630   41.742 88.887  1.00 16.95 ? 126 VAL H CG2 1 
ATOM   910  N  N   . SER A 1 117 ? 0.597   46.500 89.612  1.00 18.32 ? 127 SER H N   1 
ATOM   911  C  CA  . SER A 1 117 ? 0.510   47.803 90.275  1.00 19.22 ? 127 SER H CA  1 
ATOM   912  C  C   . SER A 1 117 ? -0.054  48.842 89.298  1.00 18.97 ? 127 SER H C   1 
ATOM   913  O  O   . SER A 1 117 ? 0.274   48.844 88.133  1.00 20.54 ? 127 SER H O   1 
ATOM   914  C  CB  . SER A 1 117 ? 1.861   48.247 90.712  1.00 20.21 ? 127 SER H CB  1 
ATOM   915  O  OG  . SER A 1 117 ? 1.803   49.553 91.347  1.00 23.96 ? 127 SER H OG  1 
ATOM   916  N  N   . SER A 1 118 ? -0.879  49.784 89.804  1.00 25.13 ? 128 SER H N   1 
ATOM   917  C  CA  . SER A 1 118 ? -1.281  50.929 88.994  1.00 27.84 ? 128 SER H CA  1 
ATOM   918  C  C   . SER A 1 118 ? -0.303  52.128 89.048  1.00 34.25 ? 128 SER H C   1 
ATOM   919  O  O   . SER A 1 118 ? -0.581  53.142 88.420  1.00 31.88 ? 128 SER H O   1 
ATOM   920  C  CB  . SER A 1 118 ? -2.677  51.358 89.375  1.00 33.30 ? 128 SER H CB  1 
ATOM   921  O  OG  . SER A 1 118 ? -2.744  51.657 90.754  1.00 35.74 ? 128 SER H OG  1 
ATOM   922  N  N   . ALA A 1 119 ? 0.879   52.044 89.693  1.00 34.90 ? 129 ALA H N   1 
ATOM   923  C  CA  . ALA A 1 119 ? 1.897   53.125 89.619  1.00 32.22 ? 129 ALA H CA  1 
ATOM   924  C  C   . ALA A 1 119 ? 2.640   53.210 88.278  1.00 32.05 ? 129 ALA H C   1 
ATOM   925  O  O   . ALA A 1 119 ? 2.718   52.216 87.576  1.00 31.37 ? 129 ALA H O   1 
ATOM   926  C  CB  . ALA A 1 119 ? 2.855   52.901 90.784  1.00 32.67 ? 129 ALA H CB  1 
ATOM   927  N  N   . SER A 1 120 ? 3.219   54.404 87.865  1.00 31.37 ? 130 SER H N   1 
ATOM   928  C  CA  . SER A 1 120 ? 3.957   54.511 86.588  1.00 32.11 ? 130 SER H CA  1 
ATOM   929  C  C   . SER A 1 120 ? 5.446   54.236 86.736  1.00 28.19 ? 130 SER H C   1 
ATOM   930  O  O   . SER A 1 120 ? 5.941   54.357 87.852  1.00 41.09 ? 130 SER H O   1 
ATOM   931  C  CB  . SER A 1 120 ? 3.693   55.851 85.858  1.00 33.29 ? 130 SER H CB  1 
ATOM   932  O  OG  . SER A 1 120 ? 2.802   55.612 84.766  1.00 32.10 ? 130 SER H OG  1 
ATOM   933  N  N   . THR A 1 121 ? 6.119   53.694 85.676  1.00 33.67 ? 131 THR H N   1 
ATOM   934  C  CA  . THR A 1 121 ? 7.566   53.584 85.715  1.00 38.05 ? 131 THR H CA  1 
ATOM   935  C  C   . THR A 1 121 ? 8.100   54.977 86.067  1.00 38.20 ? 131 THR H C   1 
ATOM   936  O  O   . THR A 1 121 ? 7.481   56.028 85.827  1.00 37.02 ? 131 THR H O   1 
ATOM   937  C  CB  . THR A 1 121 ? 8.243   52.913 84.496  1.00 39.65 ? 131 THR H CB  1 
ATOM   938  O  OG1 . THR A 1 121 ? 8.133   53.788 83.380  1.00 35.54 ? 131 THR H OG1 1 
ATOM   939  C  CG2 . THR A 1 121 ? 7.723   51.529 84.118  1.00 36.33 ? 131 THR H CG2 1 
ATOM   940  N  N   . LYS A 1 122 ? 9.200   54.963 86.826  1.00 36.21 ? 132 LYS H N   1 
ATOM   941  C  CA  . LYS A 1 122 ? 9.765   56.215 87.294  1.00 37.52 ? 132 LYS H CA  1 
ATOM   942  C  C   . LYS A 1 122 ? 11.241  55.981 87.506  1.00 36.63 ? 132 LYS H C   1 
ATOM   943  O  O   . LYS A 1 122 ? 11.636  55.003 88.138  1.00 29.57 ? 132 LYS H O   1 
ATOM   944  C  CB  . LYS A 1 122 ? 9.142   56.754 88.574  1.00 38.45 ? 132 LYS H CB  1 
ATOM   945  C  CG  . LYS A 1 122 ? 9.989   57.827 89.239  1.00 42.37 ? 132 LYS H CG  1 
ATOM   946  C  CD  . LYS A 1 122 ? 9.351   58.447 90.461  1.00 46.16 ? 132 LYS H CD  1 
ATOM   947  C  CE  . LYS A 1 122 ? 10.059  59.712 90.912  1.00 47.73 ? 132 LYS H CE  1 
ATOM   948  N  NZ  . LYS A 1 122 ? 9.969   60.787 89.889  1.00 51.72 ? 132 LYS H NZ  1 
ATOM   949  N  N   . GLY A 1 123 ? 12.038  56.851 86.876  1.00 31.88 ? 133 GLY H N   1 
ATOM   950  C  CA  . GLY A 1 123 ? 13.458  56.617 86.802  1.00 28.62 ? 133 GLY H CA  1 
ATOM   951  C  C   . GLY A 1 123 ? 14.134  57.203 88.054  1.00 22.78 ? 133 GLY H C   1 
ATOM   952  O  O   . GLY A 1 123 ? 13.562  58.026 88.734  1.00 27.34 ? 133 GLY H O   1 
ATOM   953  N  N   . PRO A 1 124 ? 15.307  56.674 88.402  1.00 28.48 ? 134 PRO H N   1 
ATOM   954  C  CA  . PRO A 1 124 ? 15.974  57.146 89.605  1.00 28.23 ? 134 PRO H CA  1 
ATOM   955  C  C   . PRO A 1 124 ? 16.672  58.493 89.479  1.00 29.50 ? 134 PRO H C   1 
ATOM   956  O  O   . PRO A 1 124 ? 17.128  58.882 88.403  1.00 29.64 ? 134 PRO H O   1 
ATOM   957  C  CB  . PRO A 1 124 ? 17.009  56.053 89.834  1.00 26.72 ? 134 PRO H CB  1 
ATOM   958  C  CG  . PRO A 1 124 ? 17.360  55.527 88.490  1.00 29.73 ? 134 PRO H CG  1 
ATOM   959  C  CD  . PRO A 1 124 ? 16.071  55.649 87.696  1.00 26.89 ? 134 PRO H CD  1 
ATOM   960  N  N   . SER A 1 125 ? 16.799  59.137 90.627  1.00 29.96 ? 135 SER H N   1 
ATOM   961  C  CA  . SER A 1 125 ? 17.751  60.214 90.830  1.00 27.77 ? 135 SER H CA  1 
ATOM   962  C  C   . SER A 1 125 ? 19.039  59.591 91.358  1.00 26.96 ? 135 SER H C   1 
ATOM   963  O  O   . SER A 1 125 ? 18.986  58.709 92.212  1.00 28.75 ? 135 SER H O   1 
ATOM   964  C  CB  . SER A 1 125 ? 17.204  61.184 91.797  1.00 33.56 ? 135 SER H CB  1 
ATOM   965  O  OG  . SER A 1 125 ? 16.053  61.819 91.266  1.00 37.75 ? 135 SER H OG  1 
ATOM   966  N  N   . VAL A 1 126 ? 20.182  59.999 90.809  1.00 23.82 ? 136 VAL H N   1 
ATOM   967  C  CA  . VAL A 1 126 ? 21.434  59.407 91.210  1.00 24.35 ? 136 VAL H CA  1 
ATOM   968  C  C   . VAL A 1 126 ? 22.306  60.487 91.842  1.00 24.08 ? 136 VAL H C   1 
ATOM   969  O  O   . VAL A 1 126 ? 22.597  61.488 91.204  1.00 26.95 ? 136 VAL H O   1 
ATOM   970  C  CB  . VAL A 1 126 ? 22.170  58.724 90.055  1.00 22.29 ? 136 VAL H CB  1 
ATOM   971  C  CG1 . VAL A 1 126 ? 23.462  58.093 90.526  1.00 26.55 ? 136 VAL H CG1 1 
ATOM   972  C  CG2 . VAL A 1 126 ? 21.302  57.689 89.339  1.00 26.02 ? 136 VAL H CG2 1 
ATOM   973  N  N   . PHE A 1 127 ? 22.704  60.244 93.088  1.00 22.26 ? 137 PHE H N   1 
ATOM   974  C  CA  . PHE A 1 127 ? 23.513  61.179 93.860  1.00 25.13 ? 137 PHE H CA  1 
ATOM   975  C  C   . PHE A 1 127 ? 24.823  60.504 94.231  1.00 27.04 ? 137 PHE H C   1 
ATOM   976  O  O   . PHE A 1 127 ? 24.846  59.328 94.581  1.00 23.37 ? 137 PHE H O   1 
ATOM   977  C  CB  . PHE A 1 127 ? 22.762  61.572 95.127  1.00 26.26 ? 137 PHE H CB  1 
ATOM   978  C  CG  . PHE A 1 127 ? 21.410  62.173 94.856  1.00 25.30 ? 137 PHE H CG  1 
ATOM   979  C  CD1 . PHE A 1 127 ? 21.317  63.327 94.097  1.00 25.40 ? 137 PHE H CD1 1 
ATOM   980  C  CD2 . PHE A 1 127 ? 20.227  61.571 95.280  1.00 24.08 ? 137 PHE H CD2 1 
ATOM   981  C  CE1 . PHE A 1 127 ? 20.081  63.897 93.849  1.00 27.08 ? 137 PHE H CE1 1 
ATOM   982  C  CE2 . PHE A 1 127 ? 18.993  62.136 95.016  1.00 28.22 ? 137 PHE H CE2 1 
ATOM   983  C  CZ  . PHE A 1 127 ? 18.921  63.314 94.308  1.00 26.36 ? 137 PHE H CZ  1 
ATOM   984  N  N   . PRO A 1 128 ? 25.942  61.263 94.271  1.00 23.32 ? 138 PRO H N   1 
ATOM   985  C  CA  . PRO A 1 128 ? 27.220  60.725 94.714  1.00 22.74 ? 138 PRO H CA  1 
ATOM   986  C  C   . PRO A 1 128 ? 27.302  60.552 96.227  1.00 20.95 ? 138 PRO H C   1 
ATOM   987  O  O   . PRO A 1 128 ? 26.678  61.277 97.001  1.00 25.23 ? 138 PRO H O   1 
ATOM   988  C  CB  . PRO A 1 128 ? 28.208  61.801 94.261  1.00 25.83 ? 138 PRO H CB  1 
ATOM   989  C  CG  . PRO A 1 128 ? 27.435  63.075 94.438  1.00 27.51 ? 138 PRO H CG  1 
ATOM   990  C  CD  . PRO A 1 128 ? 26.029  62.703 93.969  1.00 28.50 ? 138 PRO H CD  1 
ATOM   991  N  N   . LEU A 1 129 ? 28.081  59.526 96.588  1.00 22.27 ? 139 LEU H N   1 
ATOM   992  C  CA  . LEU A 1 129 ? 28.565  59.259 97.923  1.00 22.41 ? 139 LEU H CA  1 
ATOM   993  C  C   . LEU A 1 129 ? 30.074  59.464 97.813  1.00 22.43 ? 139 LEU H C   1 
ATOM   994  O  O   . LEU A 1 129 ? 30.838  58.542 97.533  1.00 22.93 ? 139 LEU H O   1 
ATOM   995  C  CB  . LEU A 1 129 ? 28.172  57.827 98.327  1.00 21.90 ? 139 LEU H CB  1 
ATOM   996  C  CG  . LEU A 1 129 ? 26.673  57.578 98.485  1.00 23.15 ? 139 LEU H CG  1 
ATOM   997  C  CD1 . LEU A 1 129 ? 26.403  56.087 98.684  1.00 25.07 ? 139 LEU H CD1 1 
ATOM   998  C  CD2 . LEU A 1 129 ? 26.095  58.374 99.658  1.00 26.83 ? 139 LEU H CD2 1 
ATOM   999  N  N   . ALA A 1 130 ? 30.498  60.730 97.997  1.00 21.80 ? 140 ALA H N   1 
ATOM   1000 C  CA  . ALA A 1 130 ? 31.877  61.129 97.681  1.00 22.89 ? 140 ALA H CA  1 
ATOM   1001 C  C   . ALA A 1 130 ? 32.860  60.603 98.725  1.00 22.39 ? 140 ALA H C   1 
ATOM   1002 O  O   . ALA A 1 130 ? 32.612  60.610 99.928  1.00 23.99 ? 140 ALA H O   1 
ATOM   1003 C  CB  . ALA A 1 130 ? 31.948  62.633 97.629  1.00 25.57 ? 140 ALA H CB  1 
ATOM   1004 N  N   . PRO A 1 131 ? 34.060  60.193 98.296  1.00 22.02 ? 141 PRO H N   1 
ATOM   1005 C  CA  . PRO A 1 131 ? 35.080  59.799 99.265  1.00 23.73 ? 141 PRO H CA  1 
ATOM   1006 C  C   . PRO A 1 131 ? 35.615  61.038 99.972  1.00 22.99 ? 141 PRO H C   1 
ATOM   1007 O  O   . PRO A 1 131 ? 35.679  62.136 99.394  1.00 25.38 ? 141 PRO H O   1 
ATOM   1008 C  CB  . PRO A 1 131 ? 36.161  59.132 98.427  1.00 24.60 ? 141 PRO H CB  1 
ATOM   1009 C  CG  . PRO A 1 131 ? 36.000  59.746 97.042  1.00 24.40 ? 141 PRO H CG  1 
ATOM   1010 C  CD  . PRO A 1 131 ? 34.553  60.201 96.909  1.00 23.66 ? 141 PRO H CD  1 
ATOM   1011 N  N   . SER A 1 132 ? 36.014  60.828 101.229 1.00 23.15 ? 142 SER H N   1 
ATOM   1012 C  CA  . SER A 1 132 ? 36.550  61.882 102.054 1.00 24.20 ? 142 SER H CA  1 
ATOM   1013 C  C   . SER A 1 132 ? 37.414  61.241 103.113 1.00 24.30 ? 142 SER H C   1 
ATOM   1014 O  O   . SER A 1 132 ? 37.517  59.996 103.151 1.00 23.06 ? 142 SER H O   1 
ATOM   1015 C  CB  . SER A 1 132 ? 35.435  62.692 102.674 1.00 27.08 ? 142 SER H CB  1 
ATOM   1016 O  OG  . SER A 1 132 ? 34.788  61.944 103.712 1.00 28.30 ? 142 SER H OG  1 
ATOM   1017 N  N   . SER A 1 133 ? 37.913  62.069 104.050 1.00 24.34 ? 143 SER H N   1 
ATOM   1018 C  CA  . SER A 1 133 ? 38.672  61.525 105.166 1.00 24.79 ? 143 SER H CA  1 
ATOM   1019 C  C   . SER A 1 133 ? 37.814  60.559 106.000 1.00 25.53 ? 143 SER H C   1 
ATOM   1020 O  O   . SER A 1 133 ? 38.346  59.611 106.611 1.00 25.78 ? 143 SER H O   1 
ATOM   1021 C  CB  . SER A 1 133 ? 39.324  62.588 106.003 1.00 27.05 ? 143 SER H CB  1 
ATOM   1022 O  OG  . SER A 1 133 ? 38.378  63.411 106.689 1.00 30.72 ? 143 SER H OG  1 
ATOM   1023 N  N   . LYS A 1 134 ? 36.491  60.756 105.982 1.00 26.35 ? 144 LYS H N   1 
ATOM   1024 C  CA  . LYS A 1 134 ? 35.582  59.927 106.763 1.00 25.43 ? 144 LYS H CA  1 
ATOM   1025 C  C   . LYS A 1 134 ? 35.403  58.537 106.146 1.00 29.19 ? 144 LYS H C   1 
ATOM   1026 O  O   . LYS A 1 134 ? 34.962  57.628 106.853 1.00 35.06 ? 144 LYS H O   1 
ATOM   1027 C  CB  . LYS A 1 134 ? 34.225  60.626 106.909 1.00 26.57 ? 144 LYS H CB  1 
ATOM   1028 C  CG  . LYS A 1 134 ? 34.315  61.962 107.641 1.00 30.12 ? 144 LYS H CG  1 
ATOM   1029 C  CD  . LYS A 1 134 ? 32.963  62.661 107.815 1.00 35.15 ? 144 LYS H CD  1 
ATOM   1030 C  CE  . LYS A 1 134 ? 32.264  62.958 106.498 1.00 35.88 ? 144 LYS H CE  1 
ATOM   1031 N  NZ  . LYS A 1 134 ? 33.044  63.892 105.634 1.00 38.39 ? 144 LYS H NZ  1 
ATOM   1032 N  N   . SER A 1 135 ? 35.717  58.366 104.849 1.00 24.43 ? 145 SER H N   1 
ATOM   1033 C  CA  . SER A 1 135 ? 35.581  57.062 104.202 1.00 25.37 ? 145 SER H CA  1 
ATOM   1034 C  C   . SER A 1 135 ? 36.947  56.413 103.885 1.00 25.15 ? 145 SER H C   1 
ATOM   1035 O  O   . SER A 1 135 ? 36.963  55.385 103.202 1.00 24.41 ? 145 SER H O   1 
ATOM   1036 C  CB  . SER A 1 135 ? 34.736  57.148 102.950 1.00 27.39 ? 145 SER H CB  1 
ATOM   1037 O  OG  . SER A 1 135 ? 35.503  57.752 101.925 1.00 25.97 ? 145 SER H OG  1 
ATOM   1038 N  N   . THR A 1 136 ? 38.059  56.979 104.423 1.00 27.08 ? 146 THR H N   1 
ATOM   1039 C  CA  . THR A 1 136 ? 39.416  56.715 103.941 1.00 30.53 ? 146 THR H CA  1 
ATOM   1040 C  C   . THR A 1 136 ? 40.412  56.501 105.075 1.00 38.84 ? 146 THR H C   1 
ATOM   1041 O  O   . THR A 1 136 ? 40.611  57.388 105.921 1.00 33.62 ? 146 THR H O   1 
ATOM   1042 C  CB  . THR A 1 136 ? 39.990  57.887 103.121 1.00 28.38 ? 146 THR H CB  1 
ATOM   1043 O  OG1 . THR A 1 136 ? 39.031  58.263 102.123 1.00 33.51 ? 146 THR H OG1 1 
ATOM   1044 C  CG2 . THR A 1 136 ? 41.277  57.534 102.403 1.00 34.27 ? 146 THR H CG2 1 
ATOM   1045 N  N   . SER A 1 137 ? 41.053  55.318 105.044 1.00 35.23 ? 147 SER H N   1 
ATOM   1046 C  CA  . SER A 1 137 ? 42.198  55.014 105.893 1.00 35.03 ? 147 SER H CA  1 
ATOM   1047 C  C   . SER A 1 137 ? 42.799  53.673 105.448 1.00 30.83 ? 147 SER H C   1 
ATOM   1048 O  O   . SER A 1 137 ? 42.222  52.881 104.693 1.00 34.19 ? 147 SER H O   1 
ATOM   1049 C  CB  A SER A 1 137 ? 41.810  55.001 107.376 0.50 34.54 ? 147 SER H CB  1 
ATOM   1050 C  CB  B SER A 1 137 ? 41.846  55.007 107.371 0.50 36.31 ? 147 SER H CB  1 
ATOM   1051 O  OG  A SER A 1 137 ? 42.945  54.918 108.238 0.50 25.22 ? 147 SER H OG  1 
ATOM   1052 O  OG  B SER A 1 137 ? 41.209  53.795 107.738 0.50 29.09 ? 147 SER H OG  1 
ATOM   1053 N  N   . GLY A 1 138 ? 43.988  53.391 105.974 1.00 31.10 ? 148 GLY H N   1 
ATOM   1054 C  CA  . GLY A 1 138 ? 44.673  52.173 105.594 1.00 27.24 ? 148 GLY H CA  1 
ATOM   1055 C  C   . GLY A 1 138 ? 44.905  52.089 104.090 1.00 33.54 ? 148 GLY H C   1 
ATOM   1056 O  O   . GLY A 1 138 ? 45.059  50.995 103.540 1.00 32.92 ? 148 GLY H O   1 
ATOM   1057 N  N   . GLY A 1 139 ? 44.900  53.249 103.421 1.00 26.63 ? 149 GLY H N   1 
ATOM   1058 C  CA  . GLY A 1 139 ? 45.341  53.284 102.042 1.00 26.26 ? 149 GLY H CA  1 
ATOM   1059 C  C   . GLY A 1 139 ? 44.190  53.027 101.077 1.00 25.54 ? 149 GLY H C   1 
ATOM   1060 O  O   . GLY A 1 139 ? 44.420  52.905 99.885  1.00 25.39 ? 149 GLY H O   1 
ATOM   1061 N  N   . THR A 1 140 ? 42.954  52.977 101.622 1.00 25.36 ? 150 THR H N   1 
ATOM   1062 C  CA  . THR A 1 140 ? 41.779  52.688 100.812 1.00 24.82 ? 150 THR H CA  1 
ATOM   1063 C  C   . THR A 1 140 ? 40.671  53.676 101.162 1.00 22.08 ? 150 THR H C   1 
ATOM   1064 O  O   . THR A 1 140 ? 40.584  54.152 102.297 1.00 25.44 ? 150 THR H O   1 
ATOM   1065 C  CB  . THR A 1 140 ? 41.232  51.253 100.938 1.00 28.95 ? 150 THR H CB  1 
ATOM   1066 O  OG1 . THR A 1 140 ? 40.656  51.102 102.235 1.00 30.97 ? 150 THR H OG1 1 
ATOM   1067 C  CG2 . THR A 1 140 ? 42.268  50.169 100.764 1.00 28.12 ? 150 THR H CG2 1 
ATOM   1068 N  N   . ALA A 1 141 ? 39.870  54.001 100.128 1.00 22.88 ? 151 ALA H N   1 
ATOM   1069 C  CA  . ALA A 1 141 ? 38.755  54.905 100.268 1.00 21.97 ? 151 ALA H CA  1 
ATOM   1070 C  C   . ALA A 1 141 ? 37.503  54.213 99.735  1.00 20.25 ? 151 ALA H C   1 
ATOM   1071 O  O   . ALA A 1 141 ? 37.538  53.611 98.677  1.00 21.68 ? 151 ALA H O   1 
ATOM   1072 C  CB  . ALA A 1 141 ? 39.002  56.174 99.478  1.00 23.35 ? 151 ALA H CB  1 
ATOM   1073 N  N   . ALA A 1 142 ? 36.396  54.470 100.437 1.00 20.28 ? 152 ALA H N   1 
ATOM   1074 C  CA  . ALA A 1 142 ? 35.068  54.064 100.015 1.00 23.39 ? 152 ALA H CA  1 
ATOM   1075 C  C   . ALA A 1 142 ? 34.335  55.229 99.372  1.00 22.74 ? 152 ALA H C   1 
ATOM   1076 O  O   . ALA A 1 142 ? 34.417  56.368 99.825  1.00 22.53 ? 152 ALA H O   1 
ATOM   1077 C  CB  . ALA A 1 142 ? 34.310  53.552 101.203 1.00 25.54 ? 152 ALA H CB  1 
ATOM   1078 N  N   . LEU A 1 143 ? 33.638  54.939 98.267  1.00 22.47 ? 153 LEU H N   1 
ATOM   1079 C  CA  . LEU A 1 143 ? 32.785  55.895 97.597  1.00 22.53 ? 153 LEU H CA  1 
ATOM   1080 C  C   . LEU A 1 143 ? 31.613  55.152 96.983  1.00 22.75 ? 153 LEU H C   1 
ATOM   1081 O  O   . LEU A 1 143 ? 31.596  53.909 96.998  1.00 25.11 ? 153 LEU H O   1 
ATOM   1082 C  CB  . LEU A 1 143 ? 33.620  56.636 96.534  1.00 24.57 ? 153 LEU H CB  1 
ATOM   1083 C  CG  . LEU A 1 143 ? 34.215  55.775 95.423  1.00 25.34 ? 153 LEU H CG  1 
ATOM   1084 C  CD1 . LEU A 1 143 ? 33.501  55.964 94.097  1.00 31.77 ? 153 LEU H CD1 1 
ATOM   1085 C  CD2 . LEU A 1 143 ? 35.701  56.068 95.271  1.00 31.93 ? 153 LEU H CD2 1 
ATOM   1086 N  N   . GLY A 1 144 ? 30.647  55.882 96.424  1.00 20.50 ? 154 GLY H N   1 
ATOM   1087 C  CA  . GLY A 1 144 ? 29.488  55.195 95.898  1.00 21.03 ? 154 GLY H CA  1 
ATOM   1088 C  C   . GLY A 1 144 ? 28.485  56.124 95.217  1.00 22.74 ? 154 GLY H C   1 
ATOM   1089 O  O   . GLY A 1 144 ? 28.764  57.315 94.992  1.00 20.91 ? 154 GLY H O   1 
ATOM   1090 N  N   . CYS A 1 145 ? 27.290  55.566 94.947  1.00 22.82 ? 155 CYS H N   1 
ATOM   1091 C  CA  . CYS A 1 145 ? 26.167  56.243 94.303  1.00 21.78 ? 155 CYS H CA  1 
ATOM   1092 C  C   . CYS A 1 145 ? 24.892  55.803 95.003  1.00 20.33 ? 155 CYS H C   1 
ATOM   1093 O  O   . CYS A 1 145 ? 24.771  54.616 95.287  1.00 25.14 ? 155 CYS H O   1 
ATOM   1094 C  CB  . CYS A 1 145 ? 26.043  55.877 92.830  1.00 25.21 ? 155 CYS H CB  1 
ATOM   1095 S  SG  . CYS A 1 145 ? 27.232  56.833 91.862  1.00 27.83 ? 155 CYS H SG  1 
ATOM   1096 N  N   . LEU A 1 146 ? 24.079  56.773 95.413  1.00 20.88 ? 156 LEU H N   1 
ATOM   1097 C  CA  . LEU A 1 146 ? 22.760  56.576 95.944  1.00 20.54 ? 156 LEU H CA  1 
ATOM   1098 C  C   . LEU A 1 146 ? 21.815  56.674 94.755  1.00 24.94 ? 156 LEU H C   1 
ATOM   1099 O  O   . LEU A 1 146 ? 21.744  57.706 94.101  1.00 22.77 ? 156 LEU H O   1 
ATOM   1100 C  CB  . LEU A 1 146 ? 22.472  57.672 96.965  1.00 21.10 ? 156 LEU H CB  1 
ATOM   1101 C  CG  . LEU A 1 146 ? 21.066  57.703 97.555  1.00 21.93 ? 156 LEU H CG  1 
ATOM   1102 C  CD1 . LEU A 1 146 ? 20.811  56.418 98.303  1.00 24.36 ? 156 LEU H CD1 1 
ATOM   1103 C  CD2 . LEU A 1 146 ? 20.870  58.909 98.444  1.00 22.97 ? 156 LEU H CD2 1 
ATOM   1104 N  N   . VAL A 1 147 ? 21.064  55.593 94.528  1.00 25.50 ? 157 VAL H N   1 
ATOM   1105 C  CA  . VAL A 1 147 ? 20.085  55.506 93.449  1.00 22.22 ? 157 VAL H CA  1 
ATOM   1106 C  C   . VAL A 1 147 ? 18.676  55.568 94.026  1.00 23.42 ? 157 VAL H C   1 
ATOM   1107 O  O   . VAL A 1 147 ? 18.146  54.586 94.560  1.00 26.41 ? 157 VAL H O   1 
ATOM   1108 C  CB  . VAL A 1 147 ? 20.363  54.220 92.666  1.00 21.95 ? 157 VAL H CB  1 
ATOM   1109 C  CG1 . VAL A 1 147 ? 19.428  54.036 91.479  1.00 22.70 ? 157 VAL H CG1 1 
ATOM   1110 C  CG2 . VAL A 1 147 ? 21.792  54.156 92.189  1.00 22.09 ? 157 VAL H CG2 1 
ATOM   1111 N  N   . LYS A 1 148 ? 18.067  56.736 93.982  1.00 22.91 ? 158 LYS H N   1 
ATOM   1112 C  CA  . LYS A 1 148 ? 16.921  57.003 94.817  1.00 23.48 ? 158 LYS H CA  1 
ATOM   1113 C  C   . LYS A 1 148 ? 15.666  57.201 93.964  1.00 28.01 ? 158 LYS H C   1 
ATOM   1114 O  O   . LYS A 1 148 ? 15.723  57.796 92.895  1.00 27.75 ? 158 LYS H O   1 
ATOM   1115 C  CB  . LYS A 1 148 ? 17.211  58.175 95.749  1.00 26.84 ? 158 LYS H CB  1 
ATOM   1116 C  CG  . LYS A 1 148 ? 16.126  58.401 96.783  1.00 32.12 ? 158 LYS H CG  1 
ATOM   1117 C  CD  . LYS A 1 148 ? 16.511  59.392 97.803  1.00 34.45 ? 158 LYS H CD  1 
ATOM   1118 C  CE  . LYS A 1 148 ? 15.620  59.306 99.013  1.00 41.77 ? 158 LYS H CE  1 
ATOM   1119 N  NZ  . LYS A 1 148 ? 14.230  59.654 98.694  1.00 45.40 ? 158 LYS H NZ  1 
ATOM   1120 N  N   . ASP A 1 149 ? 14.543  56.730 94.515  1.00 26.07 ? 159 ASP H N   1 
ATOM   1121 C  CA  . ASP A 1 149 ? 13.189  57.064 94.079  1.00 23.59 ? 159 ASP H CA  1 
ATOM   1122 C  C   . ASP A 1 149 ? 12.905  56.552 92.663  1.00 27.37 ? 159 ASP H C   1 
ATOM   1123 O  O   . ASP A 1 149 ? 12.653  57.319 91.741  1.00 30.52 ? 159 ASP H O   1 
ATOM   1124 C  CB  . ASP A 1 149 ? 12.908  58.548 94.231  1.00 24.03 ? 159 ASP H CB  1 
ATOM   1125 C  CG  . ASP A 1 149 ? 12.909  59.066 95.651  1.00 26.51 ? 159 ASP H CG  1 
ATOM   1126 O  OD1 . ASP A 1 149 ? 12.706  58.269 96.625  1.00 29.65 ? 159 ASP H OD1 1 
ATOM   1127 O  OD2 . ASP A 1 149 ? 13.032  60.288 95.777  1.00 33.02 ? 159 ASP H OD2 1 
ATOM   1128 N  N   . TYR A 1 150 ? 12.916  55.233 92.501  1.00 22.78 ? 160 TYR H N   1 
ATOM   1129 C  CA  . TYR A 1 150 ? 12.535  54.640 91.224  1.00 23.39 ? 160 TYR H CA  1 
ATOM   1130 C  C   . TYR A 1 150 ? 11.451  53.580 91.438  1.00 27.16 ? 160 TYR H C   1 
ATOM   1131 O  O   . TYR A 1 150 ? 11.291  53.024 92.523  1.00 24.59 ? 160 TYR H O   1 
ATOM   1132 C  CB  . TYR A 1 150 ? 13.748  54.096 90.499  1.00 24.36 ? 160 TYR H CB  1 
ATOM   1133 C  CG  . TYR A 1 150 ? 14.422  52.925 91.167  1.00 24.67 ? 160 TYR H CG  1 
ATOM   1134 C  CD1 . TYR A 1 150 ? 14.012  51.630 90.948  1.00 25.30 ? 160 TYR H CD1 1 
ATOM   1135 C  CD2 . TYR A 1 150 ? 15.420  53.123 92.116  1.00 23.29 ? 160 TYR H CD2 1 
ATOM   1136 C  CE1 . TYR A 1 150 ? 14.618  50.556 91.573  1.00 23.21 ? 160 TYR H CE1 1 
ATOM   1137 C  CE2 . TYR A 1 150 ? 16.039  52.056 92.748  1.00 23.24 ? 160 TYR H CE2 1 
ATOM   1138 C  CZ  . TYR A 1 150 ? 15.609  50.768 92.527  1.00 23.59 ? 160 TYR H CZ  1 
ATOM   1139 O  OH  . TYR A 1 150 ? 16.183  49.671 93.126  1.00 26.49 ? 160 TYR H OH  1 
ATOM   1140 N  N   . PHE A 1 151 ? 10.692  53.333 90.361  1.00 26.56 ? 161 PHE H N   1 
ATOM   1141 C  CA  . PHE A 1 151 ? 9.677   52.281 90.371  1.00 26.32 ? 161 PHE H CA  1 
ATOM   1142 C  C   . PHE A 1 151 ? 9.415   51.824 88.935  1.00 31.65 ? 161 PHE H C   1 
ATOM   1143 O  O   . PHE A 1 151 ? 9.408   52.672 88.045  1.00 30.04 ? 161 PHE H O   1 
ATOM   1144 C  CB  . PHE A 1 151 ? 8.422   52.765 91.071  1.00 27.63 ? 161 PHE H CB  1 
ATOM   1145 C  CG  . PHE A 1 151 ? 7.353   51.708 91.201  1.00 25.35 ? 161 PHE H CG  1 
ATOM   1146 C  CD1 . PHE A 1 151 ? 7.373   50.819 92.260  1.00 27.93 ? 161 PHE H CD1 1 
ATOM   1147 C  CD2 . PHE A 1 151 ? 6.378   51.560 90.223  1.00 26.70 ? 161 PHE H CD2 1 
ATOM   1148 C  CE1 . PHE A 1 151 ? 6.452   49.783 92.349  1.00 26.33 ? 161 PHE H CE1 1 
ATOM   1149 C  CE2 . PHE A 1 151 ? 5.436   50.545 90.337  1.00 26.10 ? 161 PHE H CE2 1 
ATOM   1150 C  CZ  . PHE A 1 151 ? 5.467   49.676 91.402  1.00 25.13 ? 161 PHE H CZ  1 
ATOM   1151 N  N   . PRO A 1 152 ? 9.203   50.520 88.644  1.00 25.31 ? 162 PRO H N   1 
ATOM   1152 C  CA  . PRO A 1 152 ? 9.417   49.396 89.561  1.00 24.40 ? 162 PRO H CA  1 
ATOM   1153 C  C   . PRO A 1 152 ? 10.876  48.990 89.608  1.00 27.22 ? 162 PRO H C   1 
ATOM   1154 O  O   . PRO A 1 152 ? 11.745  49.616 88.997  1.00 25.65 ? 162 PRO H O   1 
ATOM   1155 C  CB  . PRO A 1 152 ? 8.534   48.298 88.903  1.00 24.08 ? 162 PRO H CB  1 
ATOM   1156 C  CG  . PRO A 1 152 ? 8.765   48.538 87.426  1.00 26.52 ? 162 PRO H CG  1 
ATOM   1157 C  CD  . PRO A 1 152 ? 8.765   50.035 87.321  1.00 25.82 ? 162 PRO H CD  1 
ATOM   1158 N  N   . GLU A 1 153 ? 11.160  47.908 90.320  1.00 23.53 ? 163 GLU H N   1 
ATOM   1159 C  CA  . GLU A 1 153 ? 12.398  47.197 90.169  1.00 23.40 ? 163 GLU H CA  1 
ATOM   1160 C  C   . GLU A 1 153 ? 12.460  46.644 88.747  1.00 25.04 ? 163 GLU H C   1 
ATOM   1161 O  O   . GLU A 1 153 ? 11.393  46.504 88.107  1.00 25.56 ? 163 GLU H O   1 
ATOM   1162 C  CB  . GLU A 1 153 ? 12.459  46.075 91.206  1.00 24.33 ? 163 GLU H CB  1 
ATOM   1163 C  CG  . GLU A 1 153 ? 12.812  46.545 92.601  1.00 28.02 ? 163 GLU H CG  1 
ATOM   1164 C  CD  . GLU A 1 153 ? 14.308  46.459 92.890  1.00 38.70 ? 163 GLU H CD  1 
ATOM   1165 O  OE1 . GLU A 1 153 ? 15.112  47.267 92.307  1.00 33.85 ? 163 GLU H OE1 1 
ATOM   1166 O  OE2 . GLU A 1 153 ? 14.687  45.533 93.639  1.00 33.46 ? 163 GLU H OE2 1 
ATOM   1167 N  N   . PRO A 1 154 ? 13.642  46.287 88.214  1.00 24.67 ? 164 PRO H N   1 
ATOM   1168 C  CA  . PRO A 1 154 ? 14.948  46.543 88.827  1.00 27.86 ? 164 PRO H CA  1 
ATOM   1169 C  C   . PRO A 1 154 ? 15.824  47.643 88.216  1.00 30.07 ? 164 PRO H C   1 
ATOM   1170 O  O   . PRO A 1 154 ? 15.488  48.225 87.201  1.00 28.03 ? 164 PRO H O   1 
ATOM   1171 C  CB  . PRO A 1 154 ? 15.625  45.213 88.522  1.00 29.37 ? 164 PRO H CB  1 
ATOM   1172 C  CG  . PRO A 1 154 ? 15.174  44.900 87.116  1.00 29.15 ? 164 PRO H CG  1 
ATOM   1173 C  CD  . PRO A 1 154 ? 13.781  45.468 87.002  1.00 27.81 ? 164 PRO H CD  1 
ATOM   1174 N  N   . VAL A 1 155 ? 16.933  47.957 88.897  1.00 29.58 ? 165 VAL H N   1 
ATOM   1175 C  CA  . VAL A 1 155 ? 18.003  48.778 88.332  1.00 29.64 ? 165 VAL H CA  1 
ATOM   1176 C  C   . VAL A 1 155 ? 19.270  47.926 88.290  1.00 28.90 ? 165 VAL H C   1 
ATOM   1177 O  O   . VAL A 1 155 ? 19.452  47.007 89.088  1.00 30.60 ? 165 VAL H O   1 
ATOM   1178 C  CB  . VAL A 1 155 ? 18.288  50.057 89.146  1.00 31.76 ? 165 VAL H CB  1 
ATOM   1179 C  CG1 . VAL A 1 155 ? 17.179  51.073 89.061  1.00 35.50 ? 165 VAL H CG1 1 
ATOM   1180 C  CG2 . VAL A 1 155 ? 18.633  49.740 90.603  1.00 29.75 ? 165 VAL H CG2 1 
ATOM   1181 N  N   . THR A 1 156 ? 20.172  48.252 87.367  1.00 29.68 ? 166 THR H N   1 
ATOM   1182 C  CA  . THR A 1 156 ? 21.515  47.711 87.425  1.00 30.63 ? 166 THR H CA  1 
ATOM   1183 C  C   . THR A 1 156 ? 22.476  48.884 87.590  1.00 27.53 ? 166 THR H C   1 
ATOM   1184 O  O   . THR A 1 156 ? 22.183  50.019 87.171  1.00 28.20 ? 166 THR H O   1 
ATOM   1185 C  CB  . THR A 1 156 ? 21.896  46.848 86.219  1.00 35.42 ? 166 THR H CB  1 
ATOM   1186 O  OG1 . THR A 1 156 ? 21.841  47.693 85.082  1.00 36.50 ? 166 THR H OG1 1 
ATOM   1187 C  CG2 . THR A 1 156 ? 20.981  45.664 86.001  1.00 36.79 ? 166 THR H CG2 1 
ATOM   1188 N  N   . VAL A 1 157 ? 23.543  48.567 88.311  1.00 26.72 ? 167 VAL H N   1 
ATOM   1189 C  CA  . VAL A 1 157 ? 24.628  49.497 88.540  1.00 26.74 ? 167 VAL H CA  1 
ATOM   1190 C  C   . VAL A 1 157 ? 25.938  48.818 88.175  1.00 26.68 ? 167 VAL H C   1 
ATOM   1191 O  O   . VAL A 1 157 ? 26.211  47.688 88.586  1.00 25.84 ? 167 VAL H O   1 
ATOM   1192 C  CB  . VAL A 1 157 ? 24.723  49.978 89.992  1.00 26.08 ? 167 VAL H CB  1 
ATOM   1193 C  CG1 . VAL A 1 157 ? 25.790  51.044 90.127  1.00 27.34 ? 167 VAL H CG1 1 
ATOM   1194 C  CG2 . VAL A 1 157 ? 23.383  50.451 90.505  1.00 25.75 ? 167 VAL H CG2 1 
ATOM   1195 N  N   . SER A 1 158 ? 26.720  49.580 87.399  1.00 24.13 ? 168 SER H N   1 
ATOM   1196 C  CA  . SER A 1 158 ? 28.076  49.221 87.082  1.00 22.67 ? 168 SER H CA  1 
ATOM   1197 C  C   . SER A 1 158 ? 28.975  50.406 87.433  1.00 23.64 ? 168 SER H C   1 
ATOM   1198 O  O   . SER A 1 158 ? 28.470  51.501 87.685  1.00 24.70 ? 168 SER H O   1 
ATOM   1199 C  CB  . SER A 1 158 ? 28.211  48.757 85.655  1.00 28.51 ? 168 SER H CB  1 
ATOM   1200 O  OG  . SER A 1 158 ? 27.936  49.813 84.746  1.00 30.64 ? 168 SER H OG  1 
ATOM   1201 N  N   . TRP A 1 159 ? 30.284  50.144 87.434  1.00 26.57 ? 169 TRP H N   1 
ATOM   1202 C  CA  . TRP A 1 159 ? 31.306  51.145 87.690  1.00 25.16 ? 169 TRP H CA  1 
ATOM   1203 C  C   . TRP A 1 159 ? 32.297  51.172 86.531  1.00 23.99 ? 169 TRP H C   1 
ATOM   1204 O  O   . TRP A 1 159 ? 32.829  50.134 86.129  1.00 27.15 ? 169 TRP H O   1 
ATOM   1205 C  CB  . TRP A 1 159 ? 32.029  50.872 89.021  1.00 25.70 ? 169 TRP H CB  1 
ATOM   1206 C  CG  . TRP A 1 159 ? 31.193  51.196 90.217  1.00 24.55 ? 169 TRP H CG  1 
ATOM   1207 C  CD1 . TRP A 1 159 ? 30.321  50.362 90.869  1.00 25.17 ? 169 TRP H CD1 1 
ATOM   1208 C  CD2 . TRP A 1 159 ? 31.048  52.490 90.825  1.00 24.50 ? 169 TRP H CD2 1 
ATOM   1209 N  NE1 . TRP A 1 159 ? 29.677  51.043 91.871  1.00 24.04 ? 169 TRP H NE1 1 
ATOM   1210 C  CE2 . TRP A 1 159 ? 30.110  52.356 91.864  1.00 22.46 ? 169 TRP H CE2 1 
ATOM   1211 C  CE3 . TRP A 1 159 ? 31.620  53.745 90.611  1.00 21.16 ? 169 TRP H CE3 1 
ATOM   1212 C  CZ2 . TRP A 1 159 ? 29.742  53.418 92.698  1.00 25.72 ? 169 TRP H CZ2 1 
ATOM   1213 C  CZ3 . TRP A 1 159 ? 31.236  54.801 91.410  1.00 22.37 ? 169 TRP H CZ3 1 
ATOM   1214 C  CH2 . TRP A 1 159 ? 30.300  54.651 92.431  1.00 26.90 ? 169 TRP H CH2 1 
ATOM   1215 N  N   . ASN A 1 160 ? 32.558  52.384 86.050  1.00 24.09 ? 170 ASN H N   1 
ATOM   1216 C  CA  . ASN A 1 160 ? 33.527  52.612 84.997  1.00 24.99 ? 170 ASN H CA  1 
ATOM   1217 C  C   . ASN A 1 160 ? 33.201  51.702 83.818  1.00 27.92 ? 170 ASN H C   1 
ATOM   1218 O  O   . ASN A 1 160 ? 34.080  51.036 83.259  1.00 30.07 ? 170 ASN H O   1 
ATOM   1219 C  CB  . ASN A 1 160 ? 34.955  52.480 85.532  1.00 25.35 ? 170 ASN H CB  1 
ATOM   1220 C  CG  . ASN A 1 160 ? 35.328  53.642 86.428  1.00 27.41 ? 170 ASN H CG  1 
ATOM   1221 O  OD1 . ASN A 1 160 ? 34.547  54.588 86.573  1.00 27.84 ? 170 ASN H OD1 1 
ATOM   1222 N  ND2 . ASN A 1 160 ? 36.524  53.591 87.002  1.00 27.44 ? 170 ASN H ND2 1 
ATOM   1223 N  N   . SER A 1 161 ? 31.902  51.657 83.484  1.00 28.26 ? 171 SER H N   1 
ATOM   1224 C  CA  . SER A 1 161 ? 31.421  50.906 82.323  1.00 29.63 ? 171 SER H CA  1 
ATOM   1225 C  C   . SER A 1 161 ? 31.788  49.442 82.417  1.00 29.80 ? 171 SER H C   1 
ATOM   1226 O  O   . SER A 1 161 ? 32.015  48.781 81.385  1.00 35.17 ? 171 SER H O   1 
ATOM   1227 C  CB  . SER A 1 161 ? 31.916  51.484 81.047  1.00 31.56 ? 171 SER H CB  1 
ATOM   1228 O  OG  . SER A 1 161 ? 31.418  52.788 80.892  1.00 34.73 ? 171 SER H OG  1 
ATOM   1229 N  N   . GLY A 1 162 ? 31.840  48.922 83.647  1.00 28.96 ? 172 GLY H N   1 
ATOM   1230 C  CA  . GLY A 1 162 ? 32.120  47.514 83.883  1.00 31.23 ? 172 GLY H CA  1 
ATOM   1231 C  C   . GLY A 1 162 ? 33.606  47.211 84.086  1.00 31.93 ? 172 GLY H C   1 
ATOM   1232 O  O   . GLY A 1 162 ? 33.964  46.087 84.415  1.00 34.83 ? 172 GLY H O   1 
ATOM   1233 N  N   . ALA A 1 163 ? 34.479  48.214 83.927  1.00 31.68 ? 173 ALA H N   1 
ATOM   1234 C  CA  . ALA A 1 163 ? 35.912  48.021 84.133  1.00 34.28 ? 173 ALA H CA  1 
ATOM   1235 C  C   . ALA A 1 163 ? 36.275  47.857 85.611  1.00 36.56 ? 173 ALA H C   1 
ATOM   1236 O  O   . ALA A 1 163 ? 37.297  47.276 85.953  1.00 37.66 ? 173 ALA H O   1 
ATOM   1237 C  CB  . ALA A 1 163 ? 36.663  49.176 83.513  1.00 35.12 ? 173 ALA H CB  1 
ATOM   1238 N  N   . LEU A 1 164 ? 35.435  48.359 86.514  1.00 29.71 ? 174 LEU H N   1 
ATOM   1239 C  CA  . LEU A 1 164 ? 35.729  48.268 87.926  1.00 30.27 ? 174 LEU H CA  1 
ATOM   1240 C  C   . LEU A 1 164 ? 34.698  47.339 88.546  1.00 29.64 ? 174 LEU H C   1 
ATOM   1241 O  O   . LEU A 1 164 ? 33.518  47.672 88.535  1.00 30.88 ? 174 LEU H O   1 
ATOM   1242 C  CB  . LEU A 1 164 ? 35.675  49.678 88.522  1.00 28.41 ? 174 LEU H CB  1 
ATOM   1243 C  CG  . LEU A 1 164 ? 35.798  49.826 90.039  1.00 31.87 ? 174 LEU H CG  1 
ATOM   1244 C  CD1 . LEU A 1 164 ? 37.102  49.230 90.562  1.00 32.11 ? 174 LEU H CD1 1 
ATOM   1245 C  CD2 . LEU A 1 164 ? 35.663  51.292 90.410  1.00 31.63 ? 174 LEU H CD2 1 
ATOM   1246 N  N   . THR A 1 165 ? 35.191  46.214 89.085  1.00 28.44 ? 175 THR H N   1 
ATOM   1247 C  CA  . THR A 1 165 ? 34.363  45.194 89.695  1.00 32.47 ? 175 THR H CA  1 
ATOM   1248 C  C   . THR A 1 165 ? 34.856  44.836 91.089  1.00 35.13 ? 175 THR H C   1 
ATOM   1249 O  O   . THR A 1 165 ? 34.045  44.572 91.957  1.00 33.74 ? 175 THR H O   1 
ATOM   1250 C  CB  . THR A 1 165 ? 34.265  43.966 88.775  1.00 35.63 ? 175 THR H CB  1 
ATOM   1251 O  OG1 . THR A 1 165 ? 35.561  43.434 88.499  1.00 33.10 ? 175 THR H OG1 1 
ATOM   1252 C  CG2 . THR A 1 165 ? 33.608  44.319 87.462  1.00 37.99 ? 175 THR H CG2 1 
ATOM   1253 N  N   . SER A 1 166 ? 36.166  44.827 91.368  1.00 37.59 ? 176 SER H N   1 
ATOM   1254 C  CA  . SER A 1 166 ? 36.546  44.350 92.683  1.00 37.07 ? 176 SER H CA  1 
ATOM   1255 C  C   . SER A 1 166 ? 36.216  45.420 93.716  1.00 28.42 ? 176 SER H C   1 
ATOM   1256 O  O   . SER A 1 166 ? 36.261  46.611 93.420  1.00 30.59 ? 176 SER H O   1 
ATOM   1257 C  CB  . SER A 1 166 ? 37.991  43.910 92.758  1.00 42.75 ? 176 SER H CB  1 
ATOM   1258 O  OG  . SER A 1 166 ? 38.812  45.011 92.499  1.00 49.10 ? 176 SER H OG  1 
ATOM   1259 N  N   . GLY A 1 167 ? 35.814  44.968 94.905  1.00 28.33 ? 177 GLY H N   1 
ATOM   1260 C  CA  . GLY A 1 167 ? 35.501  45.858 96.009  1.00 27.75 ? 177 GLY H CA  1 
ATOM   1261 C  C   . GLY A 1 167 ? 34.140  46.538 95.910  1.00 28.47 ? 177 GLY H C   1 
ATOM   1262 O  O   . GLY A 1 167 ? 33.864  47.452 96.682  1.00 28.59 ? 177 GLY H O   1 
ATOM   1263 N  N   . VAL A 1 168 ? 33.298  46.109 94.971  1.00 24.83 ? 178 VAL H N   1 
ATOM   1264 C  CA  . VAL A 1 168 ? 31.988  46.691 94.782  1.00 23.66 ? 178 VAL H CA  1 
ATOM   1265 C  C   . VAL A 1 168 ? 30.960  45.942 95.625  1.00 25.49 ? 178 VAL H C   1 
ATOM   1266 O  O   . VAL A 1 168 ? 30.936  44.708 95.628  1.00 25.99 ? 178 VAL H O   1 
ATOM   1267 C  CB  . VAL A 1 168 ? 31.554  46.635 93.316  1.00 22.54 ? 178 VAL H CB  1 
ATOM   1268 C  CG1 . VAL A 1 168 ? 30.131  47.145 93.114  1.00 23.47 ? 178 VAL H CG1 1 
ATOM   1269 C  CG2 . VAL A 1 168 ? 32.541  47.347 92.390  1.00 23.95 ? 178 VAL H CG2 1 
ATOM   1270 N  N   . HIS A 1 169 ? 30.073  46.710 96.262  1.00 23.90 ? 179 HIS H N   1 
ATOM   1271 C  CA  . HIS A 1 169 ? 28.901  46.195 96.956  1.00 22.87 ? 179 HIS H CA  1 
ATOM   1272 C  C   . HIS A 1 169 ? 27.703  47.010 96.502  1.00 25.22 ? 179 HIS H C   1 
ATOM   1273 O  O   . HIS A 1 169 ? 27.586  48.206 96.803  1.00 22.29 ? 179 HIS H O   1 
ATOM   1274 C  CB  . HIS A 1 169 ? 29.035  46.347 98.470  1.00 24.53 ? 179 HIS H CB  1 
ATOM   1275 C  CG  . HIS A 1 169 ? 30.045  45.488 99.100  1.00 25.15 ? 179 HIS H CG  1 
ATOM   1276 N  ND1 . HIS A 1 169 ? 30.060  44.116 98.956  1.00 27.36 ? 179 HIS H ND1 1 
ATOM   1277 C  CD2 . HIS A 1 169 ? 31.094  45.802 99.854  1.00 27.20 ? 179 HIS H CD2 1 
ATOM   1278 C  CE1 . HIS A 1 169 ? 31.070  43.635 99.662  1.00 28.82 ? 179 HIS H CE1 1 
ATOM   1279 N  NE2 . HIS A 1 169 ? 31.743  44.631 100.175 1.00 28.21 ? 179 HIS H NE2 1 
ATOM   1280 N  N   . THR A 1 170 ? 26.810  46.345 95.783  1.00 24.11 ? 180 THR H N   1 
ATOM   1281 C  CA  . THR A 1 170 ? 25.556  46.935 95.385  1.00 25.03 ? 180 THR H CA  1 
ATOM   1282 C  C   . THR A 1 170 ? 24.463  46.316 96.244  1.00 26.64 ? 180 THR H C   1 
ATOM   1283 O  O   . THR A 1 170 ? 24.241  45.124 96.204  1.00 28.37 ? 180 THR H O   1 
ATOM   1284 C  CB  . THR A 1 170 ? 25.353  46.759 93.886  1.00 26.53 ? 180 THR H CB  1 
ATOM   1285 O  OG1 . THR A 1 170 ? 26.388  47.480 93.212  1.00 26.17 ? 180 THR H OG1 1 
ATOM   1286 C  CG2 . THR A 1 170 ? 24.028  47.304 93.406  1.00 27.73 ? 180 THR H CG2 1 
ATOM   1287 N  N   . PHE A 1 171 ? 23.830  47.148 97.055  1.00 22.48 ? 181 PHE H N   1 
ATOM   1288 C  CA  . PHE A 1 171 ? 22.909  46.708 98.076  1.00 22.20 ? 181 PHE H CA  1 
ATOM   1289 C  C   . PHE A 1 171 ? 21.583  46.364 97.440  1.00 25.09 ? 181 PHE H C   1 
ATOM   1290 O  O   . PHE A 1 171 ? 21.133  47.001 96.487  1.00 23.00 ? 181 PHE H O   1 
ATOM   1291 C  CB  . PHE A 1 171 ? 22.752  47.759 99.162  1.00 21.07 ? 181 PHE H CB  1 
ATOM   1292 C  CG  . PHE A 1 171 ? 24.000  47.801 99.993  1.00 21.08 ? 181 PHE H CG  1 
ATOM   1293 C  CD1 . PHE A 1 171 ? 24.157  46.939 101.069 1.00 22.62 ? 181 PHE H CD1 1 
ATOM   1294 C  CD2 . PHE A 1 171 ? 25.036  48.684 99.694  1.00 21.29 ? 181 PHE H CD2 1 
ATOM   1295 C  CE1 . PHE A 1 171 ? 25.328  46.958 101.801 1.00 21.89 ? 181 PHE H CE1 1 
ATOM   1296 C  CE2 . PHE A 1 171 ? 26.195  48.719 100.448 1.00 23.06 ? 181 PHE H CE2 1 
ATOM   1297 C  CZ  . PHE A 1 171 ? 26.347  47.818 101.488 1.00 23.30 ? 181 PHE H CZ  1 
ATOM   1298 N  N   . PRO A 1 172 ? 20.863  45.411 98.044  1.00 21.40 ? 182 PRO H N   1 
ATOM   1299 C  CA  . PRO A 1 172 ? 19.465  45.220 97.697  1.00 20.63 ? 182 PRO H CA  1 
ATOM   1300 C  C   . PRO A 1 172 ? 18.659  46.497 97.898  1.00 21.54 ? 182 PRO H C   1 
ATOM   1301 O  O   . PRO A 1 172 ? 18.904  47.272 98.822  1.00 23.40 ? 182 PRO H O   1 
ATOM   1302 C  CB  . PRO A 1 172 ? 18.964  44.137 98.673  1.00 24.52 ? 182 PRO H CB  1 
ATOM   1303 C  CG  . PRO A 1 172 ? 20.193  43.472 99.180  1.00 24.06 ? 182 PRO H CG  1 
ATOM   1304 C  CD  . PRO A 1 172 ? 21.327  44.476 99.083  1.00 23.00 ? 182 PRO H CD  1 
ATOM   1305 N  N   . ALA A 1 173 ? 17.697  46.724 96.974  1.00 23.55 ? 183 ALA H N   1 
ATOM   1306 C  CA  . ALA A 1 173 ? 16.801  47.848 97.084  1.00 25.62 ? 183 ALA H CA  1 
ATOM   1307 C  C   . ALA A 1 173 ? 15.924  47.724 98.325  1.00 23.77 ? 183 ALA H C   1 
ATOM   1308 O  O   . ALA A 1 173 ? 15.639  46.620 98.792  1.00 26.80 ? 183 ALA H O   1 
ATOM   1309 C  CB  . ALA A 1 173 ? 15.930  47.927 95.853  1.00 26.51 ? 183 ALA H CB  1 
ATOM   1310 N  N   . VAL A 1 174 ? 15.572  48.862 98.894  1.00 24.37 ? 184 VAL H N   1 
ATOM   1311 C  CA  . VAL A 1 174 ? 14.584  48.963 99.941  1.00 27.71 ? 184 VAL H CA  1 
ATOM   1312 C  C   . VAL A 1 174 ? 13.389  49.719 99.361  1.00 27.91 ? 184 VAL H C   1 
ATOM   1313 O  O   . VAL A 1 174 ? 13.511  50.676 98.617  1.00 25.61 ? 184 VAL H O   1 
ATOM   1314 C  CB  . VAL A 1 174 ? 15.052  49.663 101.228 1.00 33.56 ? 184 VAL H CB  1 
ATOM   1315 C  CG1 . VAL A 1 174 ? 16.196  48.889 101.873 1.00 33.09 ? 184 VAL H CG1 1 
ATOM   1316 C  CG2 . VAL A 1 174 ? 15.388  51.149 101.030 1.00 37.96 ? 184 VAL H CG2 1 
ATOM   1317 N  N   . LEU A 1 175 ? 12.207  49.260 99.719  1.00 29.11 ? 185 LEU H N   1 
ATOM   1318 C  CA  . LEU A 1 175 ? 10.993  49.956 99.352  1.00 27.83 ? 185 LEU H CA  1 
ATOM   1319 C  C   . LEU A 1 175 ? 10.692  50.982 100.433 1.00 29.46 ? 185 LEU H C   1 
ATOM   1320 O  O   . LEU A 1 175 ? 10.510  50.617 101.606 1.00 29.17 ? 185 LEU H O   1 
ATOM   1321 C  CB  . LEU A 1 175 ? 9.907   48.888 99.235  1.00 29.20 ? 185 LEU H CB  1 
ATOM   1322 C  CG  . LEU A 1 175 ? 8.514   49.383 98.844  1.00 31.85 ? 185 LEU H CG  1 
ATOM   1323 C  CD1 . LEU A 1 175 ? 8.520   50.116 97.509  1.00 30.20 ? 185 LEU H CD1 1 
ATOM   1324 C  CD2 . LEU A 1 175 ? 7.547   48.219 98.812  1.00 34.01 ? 185 LEU H CD2 1 
ATOM   1325 N  N   . GLN A 1 176 ? 10.693  52.260 100.045 1.00 25.45 ? 186 GLN H N   1 
ATOM   1326 C  CA  . GLN A 1 176 ? 10.394  53.362 100.940 1.00 27.16 ? 186 GLN H CA  1 
ATOM   1327 C  C   . GLN A 1 176 ? 8.877   53.433 101.144 1.00 34.67 ? 186 GLN H C   1 
ATOM   1328 O  O   . GLN A 1 176 ? 8.129   52.841 100.370 1.00 32.05 ? 186 GLN H O   1 
ATOM   1329 C  CB  . GLN A 1 176 ? 10.970  54.661 100.358 1.00 29.64 ? 186 GLN H CB  1 
ATOM   1330 C  CG  . GLN A 1 176 ? 12.453  54.545 99.998  1.00 29.08 ? 186 GLN H CG  1 
ATOM   1331 C  CD  . GLN A 1 176 ? 12.964  55.723 99.195  1.00 35.83 ? 186 GLN H CD  1 
ATOM   1332 O  OE1 . GLN A 1 176 ? 13.687  56.586 99.689  1.00 36.94 ? 186 GLN H OE1 1 
ATOM   1333 N  NE2 . GLN A 1 176 ? 12.622  55.754 97.919  1.00 31.23 ? 186 GLN H NE2 1 
ATOM   1334 N  N   . SER A 1 177 ? 8.440   54.170 102.176 1.00 35.95 ? 187 SER H N   1 
ATOM   1335 C  CA  . SER A 1 177 ? 7.016   54.368 102.445 1.00 38.91 ? 187 SER H CA  1 
ATOM   1336 C  C   . SER A 1 177 ? 6.339   55.071 101.275 1.00 37.58 ? 187 SER H C   1 
ATOM   1337 O  O   . SER A 1 177 ? 5.123   55.047 101.152 1.00 37.80 ? 187 SER H O   1 
ATOM   1338 C  CB  . SER A 1 177 ? 6.765   55.184 103.687 1.00 44.33 ? 187 SER H CB  1 
ATOM   1339 O  OG  . SER A 1 177 ? 7.982   55.529 104.314 1.00 55.37 ? 187 SER H OG  1 
ATOM   1340 N  N   . SER A 1 178 ? 7.120   55.783 100.473 1.00 37.13 ? 188 SER H N   1 
ATOM   1341 C  CA  . SER A 1 178 ? 6.572   56.476 99.319  1.00 35.66 ? 188 SER H CA  1 
ATOM   1342 C  C   . SER A 1 178 ? 6.077   55.482 98.273  1.00 33.96 ? 188 SER H C   1 
ATOM   1343 O  O   . SER A 1 178 ? 5.348   55.863 97.365  1.00 35.83 ? 188 SER H O   1 
ATOM   1344 C  CB  . SER A 1 178 ? 7.576   57.436 98.724  1.00 36.16 ? 188 SER H CB  1 
ATOM   1345 O  OG  . SER A 1 178 ? 8.701   56.737 98.205  1.00 33.46 ? 188 SER H OG  1 
ATOM   1346 N  N   . GLY A 1 179 ? 6.493   54.221 98.359  1.00 30.87 ? 189 GLY H N   1 
ATOM   1347 C  CA  . GLY A 1 179 ? 6.186   53.263 97.309  1.00 29.91 ? 189 GLY H CA  1 
ATOM   1348 C  C   . GLY A 1 179 ? 7.238   53.246 96.192  1.00 28.73 ? 189 GLY H C   1 
ATOM   1349 O  O   . GLY A 1 179 ? 7.094   52.489 95.229  1.00 28.69 ? 189 GLY H O   1 
ATOM   1350 N  N   . LEU A 1 180 ? 8.339   54.018 96.362  1.00 25.37 ? 190 LEU H N   1 
ATOM   1351 C  CA  . LEU A 1 180 ? 9.469   53.989 95.458  1.00 24.59 ? 190 LEU H CA  1 
ATOM   1352 C  C   . LEU A 1 180 ? 10.638  53.276 96.118  1.00 24.71 ? 190 LEU H C   1 
ATOM   1353 O  O   . LEU A 1 180 ? 10.788  53.394 97.337  1.00 26.82 ? 190 LEU H O   1 
ATOM   1354 C  CB  . LEU A 1 180 ? 9.902   55.425 95.128  1.00 25.86 ? 190 LEU H CB  1 
ATOM   1355 C  CG  . LEU A 1 180 ? 8.817   56.327 94.519  1.00 28.47 ? 190 LEU H CG  1 
ATOM   1356 C  CD1 . LEU A 1 180 ? 9.347   57.725 94.307  1.00 27.44 ? 190 LEU H CD1 1 
ATOM   1357 C  CD2 . LEU A 1 180 ? 8.343   55.776 93.192  1.00 29.09 ? 190 LEU H CD2 1 
ATOM   1358 N  N   . TYR A 1 181 ? 11.497  52.693 95.284  1.00 24.18 ? 191 TYR H N   1 
ATOM   1359 C  CA  . TYR A 1 181 ? 12.674  51.976 95.739  1.00 22.21 ? 191 TYR H CA  1 
ATOM   1360 C  C   . TYR A 1 181 ? 13.871  52.913 95.825  1.00 24.90 ? 191 TYR H C   1 
ATOM   1361 O  O   . TYR A 1 181 ? 13.905  53.955 95.184  1.00 22.75 ? 191 TYR H O   1 
ATOM   1362 C  CB  . TYR A 1 181 ? 13.013  50.811 94.825  1.00 22.95 ? 191 TYR H CB  1 
ATOM   1363 C  CG  . TYR A 1 181 ? 11.974  49.719 94.846  1.00 25.31 ? 191 TYR H CG  1 
ATOM   1364 C  CD1 . TYR A 1 181 ? 10.852  49.783 94.018  1.00 26.69 ? 191 TYR H CD1 1 
ATOM   1365 C  CD2 . TYR A 1 181 ? 12.082  48.671 95.741  1.00 23.67 ? 191 TYR H CD2 1 
ATOM   1366 C  CE1 . TYR A 1 181 ? 9.916   48.765 94.017  1.00 27.68 ? 191 TYR H CE1 1 
ATOM   1367 C  CE2 . TYR A 1 181 ? 11.152  47.643 95.739  1.00 27.99 ? 191 TYR H CE2 1 
ATOM   1368 C  CZ  . TYR A 1 181 ? 10.067  47.702 94.887  1.00 28.28 ? 191 TYR H CZ  1 
ATOM   1369 O  OH  . TYR A 1 181 ? 9.100   46.717 94.853  1.00 29.09 ? 191 TYR H OH  1 
ATOM   1370 N  N   . SER A 1 182 ? 14.848  52.514 96.640  1.00 22.62 ? 192 SER H N   1 
ATOM   1371 C  CA  . SER A 1 182 ? 16.133  53.167 96.702  1.00 24.61 ? 192 SER H CA  1 
ATOM   1372 C  C   . SER A 1 182 ? 17.219  52.135 96.966  1.00 23.80 ? 192 SER H C   1 
ATOM   1373 O  O   . SER A 1 182 ? 17.004  51.173 97.689  1.00 22.29 ? 192 SER H O   1 
ATOM   1374 C  CB  . SER A 1 182 ? 16.114  54.224 97.775  1.00 27.94 ? 192 SER H CB  1 
ATOM   1375 O  OG  . SER A 1 182 ? 17.351  54.906 97.855  1.00 37.54 ? 192 SER H OG  1 
ATOM   1376 N  N   . LEU A 1 183 ? 18.425  52.384 96.442  1.00 23.18 ? 193 LEU H N   1 
ATOM   1377 C  CA  . LEU A 1 183 ? 19.510  51.446 96.618  1.00 25.55 ? 193 LEU H CA  1 
ATOM   1378 C  C   . LEU A 1 183 ? 20.803  52.250 96.647  1.00 25.66 ? 193 LEU H C   1 
ATOM   1379 O  O   . LEU A 1 183 ? 20.815  53.331 96.060  1.00 22.27 ? 193 LEU H O   1 
ATOM   1380 C  CB  . LEU A 1 183 ? 19.286  50.592 95.380  1.00 30.90 ? 193 LEU H CB  1 
ATOM   1381 C  CG  . LEU A 1 183 ? 20.389  49.790 94.767  1.00 31.51 ? 193 LEU H CG  1 
ATOM   1382 C  CD1 . LEU A 1 183 ? 19.722  48.824 93.816  1.00 25.48 ? 193 LEU H CD1 1 
ATOM   1383 C  CD2 . LEU A 1 183 ? 21.423  50.657 94.084  1.00 26.86 ? 193 LEU H CD2 1 
ATOM   1384 N  N   . SER A 1 184 ? 21.849  51.767 97.338  1.00 23.25 ? 194 SER H N   1 
ATOM   1385 C  CA  . SER A 1 184 ? 23.174  52.348 97.185  1.00 21.10 ? 194 SER H CA  1 
ATOM   1386 C  C   . SER A 1 184 ? 24.099  51.295 96.590  1.00 19.81 ? 194 SER H C   1 
ATOM   1387 O  O   . SER A 1 184 ? 23.917  50.097 96.757  1.00 19.77 ? 194 SER H O   1 
ATOM   1388 C  CB  . SER A 1 184 ? 23.770  52.879 98.483  1.00 27.87 ? 194 SER H CB  1 
ATOM   1389 O  OG  . SER A 1 184 ? 23.269  54.199 98.786  1.00 32.93 ? 194 SER H OG  1 
ATOM   1390 N  N   . SER A 1 185 ? 25.135  51.767 95.883  1.00 21.12 ? 195 SER H N   1 
ATOM   1391 C  CA  . SER A 1 185 ? 26.229  50.948 95.394  1.00 20.70 ? 195 SER H CA  1 
ATOM   1392 C  C   . SER A 1 185 ? 27.518  51.655 95.829  1.00 23.88 ? 195 SER H C   1 
ATOM   1393 O  O   . SER A 1 185 ? 27.669  52.856 95.575  1.00 24.78 ? 195 SER H O   1 
ATOM   1394 C  CB  . SER A 1 185 ? 26.175  50.740 93.900  1.00 22.16 ? 195 SER H CB  1 
ATOM   1395 O  OG  . SER A 1 185 ? 27.304  50.037 93.394  1.00 22.26 ? 195 SER H OG  1 
ATOM   1396 N  N   . VAL A 1 186 ? 28.411  50.890 96.437  1.00 22.51 ? 196 VAL H N   1 
ATOM   1397 C  CA  . VAL A 1 186 ? 29.664  51.412 96.981  1.00 21.60 ? 196 VAL H CA  1 
ATOM   1398 C  C   . VAL A 1 186 ? 30.840  50.596 96.465  1.00 22.94 ? 196 VAL H C   1 
ATOM   1399 O  O   . VAL A 1 186 ? 30.710  49.451 96.067  1.00 21.32 ? 196 VAL H O   1 
ATOM   1400 C  CB  . VAL A 1 186 ? 29.673  51.466 98.511  1.00 21.44 ? 196 VAL H CB  1 
ATOM   1401 C  CG1 . VAL A 1 186 ? 28.547  52.325 99.039  1.00 21.07 ? 196 VAL H CG1 1 
ATOM   1402 C  CG2 . VAL A 1 186 ? 29.684  50.092 99.150  1.00 23.79 ? 196 VAL H CG2 1 
ATOM   1403 N  N   . VAL A 1 187 ? 32.012  51.246 96.403  1.00 21.80 ? 197 VAL H N   1 
ATOM   1404 C  CA  . VAL A 1 187 ? 33.220  50.557 95.979  1.00 23.80 ? 197 VAL H CA  1 
ATOM   1405 C  C   . VAL A 1 187 ? 34.358  51.075 96.842  1.00 23.86 ? 197 VAL H C   1 
ATOM   1406 O  O   . VAL A 1 187 ? 34.348  52.252 97.225  1.00 22.46 ? 197 VAL H O   1 
ATOM   1407 C  CB  . VAL A 1 187 ? 33.475  50.741 94.474  1.00 23.34 ? 197 VAL H CB  1 
ATOM   1408 C  CG1 . VAL A 1 187 ? 33.557  52.209 94.074  1.00 25.91 ? 197 VAL H CG1 1 
ATOM   1409 C  CG2 . VAL A 1 187 ? 34.703  49.973 94.000  1.00 24.88 ? 197 VAL H CG2 1 
ATOM   1410 N  N   . THR A 1 188 ? 35.314  50.197 97.162  1.00 23.36 ? 198 THR H N   1 
ATOM   1411 C  CA  . THR A 1 188 ? 36.537  50.589 97.860  1.00 22.61 ? 198 THR H CA  1 
ATOM   1412 C  C   . THR A 1 188 ? 37.680  50.551 96.868  1.00 23.27 ? 198 THR H C   1 
ATOM   1413 O  O   . THR A 1 188 ? 37.844  49.562 96.161  1.00 24.46 ? 198 THR H O   1 
ATOM   1414 C  CB  A THR A 1 188 ? 36.807  49.771 99.129  0.50 25.36 ? 198 THR H CB  1 
ATOM   1415 C  CB  B THR A 1 188 ? 36.834  49.624 99.024  0.50 23.44 ? 198 THR H CB  1 
ATOM   1416 O  OG1 A THR A 1 188 ? 36.781  48.378 98.843  0.50 24.29 ? 198 THR H OG1 1 
ATOM   1417 O  OG1 B THR A 1 188 ? 35.698  49.659 99.885  0.50 20.50 ? 198 THR H OG1 1 
ATOM   1418 C  CG2 A THR A 1 188 ? 35.778  50.052 100.194 0.50 25.08 ? 198 THR H CG2 1 
ATOM   1419 C  CG2 B THR A 1 188 ? 38.103  49.907 99.802  0.50 21.59 ? 198 THR H CG2 1 
ATOM   1420 N  N   . VAL A 1 189 ? 38.468  51.635 96.874  1.00 21.61 ? 199 VAL H N   1 
ATOM   1421 C  CA  . VAL A 1 189 ? 39.552  51.822 95.932  1.00 22.98 ? 199 VAL H CA  1 
ATOM   1422 C  C   . VAL A 1 189 ? 40.812  52.297 96.656  1.00 23.22 ? 199 VAL H C   1 
ATOM   1423 O  O   . VAL A 1 189 ? 40.751  52.825 97.766  1.00 24.00 ? 199 VAL H O   1 
ATOM   1424 C  CB  . VAL A 1 189 ? 39.169  52.847 94.836  1.00 23.05 ? 199 VAL H CB  1 
ATOM   1425 C  CG1 . VAL A 1 189 ? 37.926  52.387 94.087  1.00 24.82 ? 199 VAL H CG1 1 
ATOM   1426 C  CG2 . VAL A 1 189 ? 38.962  54.275 95.332  1.00 22.12 ? 199 VAL H CG2 1 
ATOM   1427 N  N   . PRO A 1 190 ? 41.978  52.238 95.988  1.00 24.73 ? 200 PRO H N   1 
ATOM   1428 C  CA  . PRO A 1 190 ? 43.195  52.807 96.579  1.00 24.58 ? 200 PRO H CA  1 
ATOM   1429 C  C   . PRO A 1 190 ? 43.037  54.312 96.775  1.00 24.50 ? 200 PRO H C   1 
ATOM   1430 O  O   . PRO A 1 190 ? 42.652  55.063 95.877  1.00 23.80 ? 200 PRO H O   1 
ATOM   1431 C  CB  . PRO A 1 190 ? 44.299  52.431 95.565  1.00 25.42 ? 200 PRO H CB  1 
ATOM   1432 C  CG  . PRO A 1 190 ? 43.708  51.298 94.758  1.00 25.99 ? 200 PRO H CG  1 
ATOM   1433 C  CD  . PRO A 1 190 ? 42.228  51.618 94.686  1.00 28.69 ? 200 PRO H CD  1 
ATOM   1434 N  N   . SER A 1 191 ? 43.392  54.801 97.981  1.00 24.94 ? 201 SER H N   1 
ATOM   1435 C  CA  . SER A 1 191 ? 43.292  56.225 98.232  1.00 26.94 ? 201 SER H CA  1 
ATOM   1436 C  C   . SER A 1 191 ? 44.281  56.974 97.339  1.00 26.06 ? 201 SER H C   1 
ATOM   1437 O  O   . SER A 1 191 ? 43.971  58.061 96.868  1.00 27.55 ? 201 SER H O   1 
ATOM   1438 C  CB  . SER A 1 191 ? 43.449  56.516 99.690  1.00 27.38 ? 201 SER H CB  1 
ATOM   1439 O  OG  . SER A 1 191 ? 44.678  55.995 100.173 1.00 32.02 ? 201 SER H OG  1 
ATOM   1440 N  N   . SER A 1 192 ? 45.378  56.329 96.969  1.00 24.05 ? 202 SER H N   1 
ATOM   1441 C  CA  . SER A 1 192 ? 46.316  56.972 96.051  1.00 27.05 ? 202 SER H CA  1 
ATOM   1442 C  C   . SER A 1 192 ? 45.718  57.228 94.652  1.00 29.45 ? 202 SER H C   1 
ATOM   1443 O  O   . SER A 1 192 ? 46.264  58.053 93.890  1.00 29.11 ? 202 SER H O   1 
ATOM   1444 C  CB  . SER A 1 192 ? 47.570  56.165 95.955  1.00 26.89 ? 202 SER H CB  1 
ATOM   1445 O  OG  . SER A 1 192 ? 47.288  54.923 95.356  1.00 28.11 ? 202 SER H OG  1 
ATOM   1446 N  N   . SER A 1 193 ? 44.629  56.517 94.281  1.00 27.43 ? 203 SER H N   1 
ATOM   1447 C  CA  . SER A 1 193 ? 44.040  56.668 92.949  1.00 28.60 ? 203 SER H CA  1 
ATOM   1448 C  C   . SER A 1 193 ? 43.100  57.868 92.874  1.00 29.65 ? 203 SER H C   1 
ATOM   1449 O  O   . SER A 1 193 ? 42.689  58.292 91.786  1.00 30.42 ? 203 SER H O   1 
ATOM   1450 C  CB  . SER A 1 193 ? 43.293  55.421 92.538  1.00 30.27 ? 203 SER H CB  1 
ATOM   1451 O  OG  . SER A 1 193 ? 42.061  55.312 93.277  1.00 29.90 ? 203 SER H OG  1 
ATOM   1452 N  N   . LEU A 1 194 ? 42.739  58.440 94.015  1.00 26.06 ? 204 LEU H N   1 
ATOM   1453 C  CA  . LEU A 1 194 ? 41.680  59.448 94.015  1.00 26.76 ? 204 LEU H CA  1 
ATOM   1454 C  C   . LEU A 1 194 ? 41.986  60.679 93.158  1.00 34.31 ? 204 LEU H C   1 
ATOM   1455 O  O   . LEU A 1 194 ? 41.070  61.225 92.542  1.00 31.80 ? 204 LEU H O   1 
ATOM   1456 C  CB  . LEU A 1 194 ? 41.366  59.820 95.465  1.00 28.46 ? 204 LEU H CB  1 
ATOM   1457 C  CG  . LEU A 1 194 ? 40.657  58.712 96.234  1.00 26.22 ? 204 LEU H CG  1 
ATOM   1458 C  CD1 . LEU A 1 194 ? 40.287  59.192 97.633  1.00 26.64 ? 204 LEU H CD1 1 
ATOM   1459 C  CD2 . LEU A 1 194 ? 39.421  58.258 95.452  1.00 27.70 ? 204 LEU H CD2 1 
ATOM   1460 N  N   . GLY A 1 195 ? 43.236  61.147 93.126  1.00 37.72 ? 205 GLY H N   1 
ATOM   1461 C  CA  . GLY A 1 195 ? 43.549  62.276 92.248  1.00 43.10 ? 205 GLY H CA  1 
ATOM   1462 C  C   . GLY A 1 195 ? 43.435  61.960 90.753  1.00 43.70 ? 205 GLY H C   1 
ATOM   1463 O  O   . GLY A 1 195 ? 43.138  62.832 89.939  1.00 50.87 ? 205 GLY H O   1 
ATOM   1464 N  N   . THR A 1 196 ? 43.647  60.692 90.418  1.00 36.75 ? 206 THR H N   1 
ATOM   1465 C  CA  . THR A 1 196 ? 44.139  60.277 89.126  1.00 38.70 ? 206 THR H CA  1 
ATOM   1466 C  C   . THR A 1 196 ? 43.055  59.526 88.359  1.00 34.14 ? 206 THR H C   1 
ATOM   1467 O  O   . THR A 1 196 ? 42.906  59.679 87.153  1.00 34.97 ? 206 THR H O   1 
ATOM   1468 C  CB  . THR A 1 196 ? 45.356  59.375 89.363  1.00 41.37 ? 206 THR H CB  1 
ATOM   1469 O  OG1 . THR A 1 196 ? 46.311  60.204 90.028  1.00 48.53 ? 206 THR H OG1 1 
ATOM   1470 C  CG2 . THR A 1 196 ? 45.945  58.759 88.112  1.00 42.88 ? 206 THR H CG2 1 
ATOM   1471 N  N   . GLN A 1 197 ? 42.373  58.622 89.055  1.00 30.51 ? 207 GLN H N   1 
ATOM   1472 C  CA  . GLN A 1 197 ? 41.412  57.758 88.393  1.00 27.23 ? 207 GLN H CA  1 
ATOM   1473 C  C   . GLN A 1 197 ? 40.019  58.357 88.537  1.00 28.89 ? 207 GLN H C   1 
ATOM   1474 O  O   . GLN A 1 197 ? 39.629  58.790 89.621  1.00 29.95 ? 207 GLN H O   1 
ATOM   1475 C  CB  . GLN A 1 197 ? 41.451  56.377 89.035  1.00 29.50 ? 207 GLN H CB  1 
ATOM   1476 C  CG  . GLN A 1 197 ? 40.386  55.450 88.491  1.00 29.23 ? 207 GLN H CG  1 
ATOM   1477 C  CD  . GLN A 1 197 ? 40.665  55.077 87.057  1.00 34.97 ? 207 GLN H CD  1 
ATOM   1478 O  OE1 . GLN A 1 197 ? 41.752  54.599 86.730  1.00 29.81 ? 207 GLN H OE1 1 
ATOM   1479 N  NE2 . GLN A 1 197 ? 39.683  55.301 86.198  1.00 32.40 ? 207 GLN H NE2 1 
ATOM   1480 N  N   . THR A 1 198 ? 39.264  58.374 87.430  1.00 27.74 ? 208 THR H N   1 
ATOM   1481 C  CA  . THR A 1 198 ? 37.886  58.835 87.472  1.00 27.40 ? 208 THR H CA  1 
ATOM   1482 C  C   . THR A 1 198 ? 36.977  57.672 87.838  1.00 25.69 ? 208 THR H C   1 
ATOM   1483 O  O   . THR A 1 198 ? 37.188  56.572 87.351  1.00 26.49 ? 208 THR H O   1 
ATOM   1484 C  CB  . THR A 1 198 ? 37.464  59.405 86.116  1.00 33.16 ? 208 THR H CB  1 
ATOM   1485 O  OG1 . THR A 1 198 ? 38.340  60.509 85.898  1.00 37.17 ? 208 THR H OG1 1 
ATOM   1486 C  CG2 . THR A 1 198 ? 36.030  59.872 86.068  1.00 38.93 ? 208 THR H CG2 1 
ATOM   1487 N  N   . TYR A 1 199 ? 36.005  57.968 88.700  1.00 21.97 ? 209 TYR H N   1 
ATOM   1488 C  CA  . TYR A 1 199 ? 35.027  56.978 89.141  1.00 25.36 ? 209 TYR H CA  1 
ATOM   1489 C  C   . TYR A 1 199 ? 33.627  57.426 88.759  1.00 22.95 ? 209 TYR H C   1 
ATOM   1490 O  O   . TYR A 1 199 ? 33.153  58.478 89.214  1.00 25.96 ? 209 TYR H O   1 
ATOM   1491 C  CB  . TYR A 1 199 ? 35.175  56.725 90.644  1.00 24.65 ? 209 TYR H CB  1 
ATOM   1492 C  CG  . TYR A 1 199 ? 36.490  56.074 91.009  1.00 23.25 ? 209 TYR H CG  1 
ATOM   1493 C  CD1 . TYR A 1 199 ? 36.780  54.795 90.587  1.00 24.51 ? 209 TYR H CD1 1 
ATOM   1494 C  CD2 . TYR A 1 199 ? 37.483  56.780 91.687  1.00 23.70 ? 209 TYR H CD2 1 
ATOM   1495 C  CE1 . TYR A 1 199 ? 37.993  54.192 90.837  1.00 25.24 ? 209 TYR H CE1 1 
ATOM   1496 C  CE2 . TYR A 1 199 ? 38.694  56.169 91.981  1.00 25.82 ? 209 TYR H CE2 1 
ATOM   1497 C  CZ  . TYR A 1 199 ? 38.952  54.881 91.561  1.00 24.05 ? 209 TYR H CZ  1 
ATOM   1498 O  OH  . TYR A 1 199 ? 40.136  54.228 91.785  1.00 24.81 ? 209 TYR H OH  1 
ATOM   1499 N  N   . ILE A 1 200 ? 32.991  56.578 87.921  1.00 25.62 ? 210 ILE H N   1 
ATOM   1500 C  CA  . ILE A 1 200 ? 31.654  56.829 87.430  1.00 24.03 ? 210 ILE H CA  1 
ATOM   1501 C  C   . ILE A 1 200 ? 30.759  55.621 87.705  1.00 22.61 ? 210 ILE H C   1 
ATOM   1502 O  O   . ILE A 1 200 ? 31.107  54.497 87.358  1.00 22.33 ? 210 ILE H O   1 
ATOM   1503 C  CB  . ILE A 1 200 ? 31.694  57.109 85.918  1.00 25.74 ? 210 ILE H CB  1 
ATOM   1504 C  CG1 . ILE A 1 200 ? 32.614  58.285 85.573  1.00 29.07 ? 210 ILE H CG1 1 
ATOM   1505 C  CG2 . ILE A 1 200 ? 30.287  57.335 85.379  1.00 26.48 ? 210 ILE H CG2 1 
ATOM   1506 C  CD1 . ILE A 1 200 ? 32.795  58.443 84.086  1.00 28.41 ? 210 ILE H CD1 1 
ATOM   1507 N  N   . CYS A 1 201 ? 29.600  55.879 88.305  1.00 22.55 ? 211 CYS H N   1 
ATOM   1508 C  CA  . CYS A 1 201 ? 28.586  54.825 88.370  1.00 23.07 ? 211 CYS H CA  1 
ATOM   1509 C  C   . CYS A 1 201 ? 27.642  54.948 87.176  1.00 23.42 ? 211 CYS H C   1 
ATOM   1510 O  O   . CYS A 1 201 ? 27.138  56.025 86.890  1.00 25.53 ? 211 CYS H O   1 
ATOM   1511 C  CB  . CYS A 1 201 ? 27.822  54.816 89.685  1.00 25.43 ? 211 CYS H CB  1 
ATOM   1512 S  SG  . CYS A 1 201 ? 26.810  56.276 89.970  1.00 28.20 ? 211 CYS H SG  1 
ATOM   1513 N  N   . ASN A 1 202 ? 27.364  53.796 86.564  1.00 26.02 ? 212 ASN H N   1 
ATOM   1514 C  CA  . ASN A 1 202 ? 26.495  53.695 85.400  1.00 25.45 ? 212 ASN H CA  1 
ATOM   1515 C  C   . ASN A 1 202 ? 25.227  52.995 85.865  1.00 24.08 ? 212 ASN H C   1 
ATOM   1516 O  O   . ASN A 1 202 ? 25.311  51.831 86.262  1.00 26.34 ? 212 ASN H O   1 
ATOM   1517 C  CB  . ASN A 1 202 ? 27.154  52.902 84.271  1.00 26.44 ? 212 ASN H CB  1 
ATOM   1518 C  CG  . ASN A 1 202 ? 28.650  53.144 84.152  1.00 27.48 ? 212 ASN H CG  1 
ATOM   1519 O  OD1 . ASN A 1 202 ? 29.450  52.283 84.506  1.00 26.39 ? 212 ASN H OD1 1 
ATOM   1520 N  ND2 . ASN A 1 202 ? 29.022  54.309 83.662  1.00 29.08 ? 212 ASN H ND2 1 
ATOM   1521 N  N   . VAL A 1 203 ? 24.122  53.759 85.862  1.00 24.52 ? 213 VAL H N   1 
ATOM   1522 C  CA  . VAL A 1 203 ? 22.836  53.278 86.369  1.00 22.59 ? 213 VAL H CA  1 
ATOM   1523 C  C   . VAL A 1 203 ? 21.896  53.106 85.174  1.00 25.01 ? 213 VAL H C   1 
ATOM   1524 O  O   . VAL A 1 203 ? 21.684  54.045 84.412  1.00 27.91 ? 213 VAL H O   1 
ATOM   1525 C  CB  . VAL A 1 203 ? 22.252  54.255 87.392  1.00 24.15 ? 213 VAL H CB  1 
ATOM   1526 C  CG1 . VAL A 1 203 ? 20.891  53.800 87.931  1.00 27.00 ? 213 VAL H CG1 1 
ATOM   1527 C  CG2 . VAL A 1 203 ? 23.244  54.449 88.524  1.00 25.41 ? 213 VAL H CG2 1 
ATOM   1528 N  N   . ASN A 1 204 ? 21.302  51.899 85.083  1.00 28.62 ? 214 ASN H N   1 
ATOM   1529 C  CA  . ASN A 1 204 ? 20.339  51.570 84.034  1.00 29.44 ? 214 ASN H CA  1 
ATOM   1530 C  C   . ASN A 1 204 ? 19.040  51.111 84.692  1.00 26.49 ? 214 ASN H C   1 
ATOM   1531 O  O   . ASN A 1 204 ? 19.063  50.141 85.436  1.00 29.82 ? 214 ASN H O   1 
ATOM   1532 C  CB  . ASN A 1 204 ? 20.863  50.495 83.086  1.00 32.83 ? 214 ASN H CB  1 
ATOM   1533 C  CG  . ASN A 1 204 ? 20.028  50.397 81.824  1.00 33.32 ? 214 ASN H CG  1 
ATOM   1534 O  OD1 . ASN A 1 204 ? 19.071  51.140 81.618  1.00 39.18 ? 214 ASN H OD1 1 
ATOM   1535 N  ND2 . ASN A 1 204 ? 20.381  49.470 80.961  1.00 40.97 ? 214 ASN H ND2 1 
ATOM   1536 N  N   . HIS A 1 205 ? 17.975  51.878 84.490  1.00 26.25 ? 215 HIS H N   1 
ATOM   1537 C  CA  . HIS A 1 205 ? 16.625  51.483 84.897  1.00 24.58 ? 215 HIS H CA  1 
ATOM   1538 C  C   . HIS A 1 205 ? 15.823  51.186 83.614  1.00 26.28 ? 215 HIS H C   1 
ATOM   1539 O  O   . HIS A 1 205 ? 15.155  52.100 83.131  1.00 28.18 ? 215 HIS H O   1 
ATOM   1540 C  CB  . HIS A 1 205 ? 15.938  52.594 85.685  1.00 24.88 ? 215 HIS H CB  1 
ATOM   1541 C  CG  . HIS A 1 205 ? 14.592  52.240 86.243  1.00 24.69 ? 215 HIS H CG  1 
ATOM   1542 N  ND1 . HIS A 1 205 ? 13.502  53.076 86.091  1.00 26.61 ? 215 HIS H ND1 1 
ATOM   1543 C  CD2 . HIS A 1 205 ? 14.181  51.221 87.058  1.00 26.31 ? 215 HIS H CD2 1 
ATOM   1544 C  CE1 . HIS A 1 205 ? 12.449  52.528 86.738  1.00 27.28 ? 215 HIS H CE1 1 
ATOM   1545 N  NE2 . HIS A 1 205 ? 12.841  51.432 87.342  1.00 25.23 ? 215 HIS H NE2 1 
ATOM   1546 N  N   . LYS A 1 206 ? 15.913  49.936 83.143  1.00 30.48 ? 216 LYS H N   1 
ATOM   1547 C  CA  . LYS A 1 206 ? 15.294  49.533 81.879  1.00 34.53 ? 216 LYS H CA  1 
ATOM   1548 C  C   . LYS A 1 206 ? 13.807  49.879 81.886  1.00 37.68 ? 216 LYS H C   1 
ATOM   1549 O  O   . LYS A 1 206 ? 13.285  50.433 80.913  1.00 36.54 ? 216 LYS H O   1 
ATOM   1550 C  CB  . LYS A 1 206 ? 15.583  48.060 81.578  1.00 35.70 ? 216 LYS H CB  1 
ATOM   1551 C  CG  . LYS A 1 206 ? 16.966  47.793 81.002  1.00 37.12 ? 216 LYS H CG  1 
ATOM   1552 C  CD  . LYS A 1 206 ? 17.272  46.331 80.752  1.00 45.68 ? 216 LYS H CD  1 
ATOM   1553 C  CE  . LYS A 1 206 ? 18.741  46.104 80.462  1.00 52.62 ? 216 LYS H CE  1 
ATOM   1554 N  NZ  . LYS A 1 206 ? 18.990  44.786 79.833  1.00 56.14 ? 216 LYS H NZ  1 
ATOM   1555 N  N   . PRO A 1 207 ? 13.047  49.643 82.979  1.00 32.40 ? 217 PRO H N   1 
ATOM   1556 C  CA  . PRO A 1 207 ? 11.602  49.903 82.931  1.00 32.96 ? 217 PRO H CA  1 
ATOM   1557 C  C   . PRO A 1 207 ? 11.211  51.319 82.521  1.00 35.94 ? 217 PRO H C   1 
ATOM   1558 O  O   . PRO A 1 207 ? 10.160  51.541 81.912  1.00 37.25 ? 217 PRO H O   1 
ATOM   1559 C  CB  . PRO A 1 207 ? 11.161  49.585 84.373  1.00 29.31 ? 217 PRO H CB  1 
ATOM   1560 C  CG  . PRO A 1 207 ? 12.129  48.543 84.825  1.00 31.41 ? 217 PRO H CG  1 
ATOM   1561 C  CD  . PRO A 1 207 ? 13.457  48.988 84.231  1.00 33.46 ? 217 PRO H CD  1 
ATOM   1562 N  N   . SER A 1 208 ? 12.056  52.300 82.855  1.00 35.84 ? 218 SER H N   1 
ATOM   1563 C  CA  . SER A 1 208 ? 11.806  53.659 82.434  1.00 28.54 ? 218 SER H CA  1 
ATOM   1564 C  C   . SER A 1 208 ? 12.716  54.080 81.272  1.00 26.14 ? 218 SER H C   1 
ATOM   1565 O  O   . SER A 1 208 ? 12.690  55.245 80.903  1.00 32.22 ? 218 SER H O   1 
ATOM   1566 C  CB  . SER A 1 208 ? 11.902  54.645 83.563  1.00 31.70 ? 218 SER H CB  1 
ATOM   1567 O  OG  . SER A 1 208 ? 13.252  54.808 84.029  1.00 28.99 ? 218 SER H OG  1 
ATOM   1568 N  N   . ASN A 1 209 ? 13.491  53.152 80.722  1.00 32.06 ? 219 ASN H N   1 
ATOM   1569 C  CA  . ASN A 1 209 ? 14.499  53.467 79.717  1.00 40.23 ? 219 ASN H CA  1 
ATOM   1570 C  C   . ASN A 1 209 ? 15.358  54.655 80.158  1.00 42.32 ? 219 ASN H C   1 
ATOM   1571 O  O   . ASN A 1 209 ? 15.681  55.509 79.333  1.00 42.68 ? 219 ASN H O   1 
ATOM   1572 C  CB  . ASN A 1 209 ? 13.880  53.750 78.342  1.00 41.51 ? 219 ASN H CB  1 
ATOM   1573 C  CG  . ASN A 1 209 ? 13.103  52.566 77.813  1.00 49.51 ? 219 ASN H CG  1 
ATOM   1574 O  OD1 . ASN A 1 209 ? 11.883  52.632 77.696  1.00 58.47 ? 219 ASN H OD1 1 
ATOM   1575 N  ND2 . ASN A 1 209 ? 13.787  51.465 77.542  1.00 53.96 ? 219 ASN H ND2 1 
ATOM   1576 N  N   . THR A 1 210 ? 15.730  54.681 81.447  1.00 39.91 ? 220 THR H N   1 
ATOM   1577 C  CA  . THR A 1 210 ? 16.594  55.698 82.034  1.00 40.24 ? 220 THR H CA  1 
ATOM   1578 C  C   . THR A 1 210 ? 18.010  55.136 82.166  1.00 39.81 ? 220 THR H C   1 
ATOM   1579 O  O   . THR A 1 210 ? 18.203  54.029 82.701  1.00 35.22 ? 220 THR H O   1 
ATOM   1580 C  CB  . THR A 1 210 ? 16.101  56.123 83.424  1.00 42.58 ? 220 THR H CB  1 
ATOM   1581 O  OG1 . THR A 1 210 ? 14.854  56.809 83.319  1.00 43.14 ? 220 THR H OG1 1 
ATOM   1582 C  CG2 . THR A 1 210 ? 17.079  57.012 84.165  1.00 42.27 ? 220 THR H CG2 1 
ATOM   1583 N  N   . LYS A 1 211 ? 18.992  55.922 81.690  1.00 34.64 ? 221 LYS H N   1 
ATOM   1584 C  CA  . LYS A 1 211 ? 20.400  55.632 81.892  1.00 35.87 ? 221 LYS H CA  1 
ATOM   1585 C  C   . LYS A 1 211 ? 21.069  56.895 82.429  1.00 37.23 ? 221 LYS H C   1 
ATOM   1586 O  O   . LYS A 1 211 ? 20.903  57.994 81.896  1.00 33.69 ? 221 LYS H O   1 
ATOM   1587 C  CB  . LYS A 1 211 ? 21.068  55.160 80.607  1.00 37.97 ? 221 LYS H CB  1 
ATOM   1588 C  CG  . LYS A 1 211 ? 20.290  54.097 79.855  1.00 44.37 ? 221 LYS H CG  1 
ATOM   1589 C  CD  . LYS A 1 211 ? 20.972  53.616 78.591  1.00 52.39 ? 221 LYS H CD  1 
ATOM   1590 C  CE  . LYS A 1 211 ? 21.718  52.314 78.771  1.00 59.50 ? 221 LYS H CE  1 
ATOM   1591 N  NZ  . LYS A 1 211 ? 21.800  51.573 77.491  1.00 62.05 ? 221 LYS H NZ  1 
ATOM   1592 N  N   . VAL A 1 212 ? 21.788  56.743 83.540  1.00 34.06 ? 222 VAL H N   1 
ATOM   1593 C  CA  . VAL A 1 212 ? 22.459  57.871 84.162  1.00 32.68 ? 222 VAL H CA  1 
ATOM   1594 C  C   . VAL A 1 212 ? 23.898  57.438 84.416  1.00 30.39 ? 222 VAL H C   1 
ATOM   1595 O  O   . VAL A 1 212 ? 24.125  56.355 84.912  1.00 26.76 ? 222 VAL H O   1 
ATOM   1596 C  CB  . VAL A 1 212 ? 21.799  58.334 85.477  1.00 34.66 ? 222 VAL H CB  1 
ATOM   1597 C  CG1 . VAL A 1 212 ? 22.633  59.410 86.167  1.00 34.05 ? 222 VAL H CG1 1 
ATOM   1598 C  CG2 . VAL A 1 212 ? 20.375  58.825 85.279  1.00 39.25 ? 222 VAL H CG2 1 
ATOM   1599 N  N   . ASP A 1 213 ? 24.863  58.285 84.052  1.00 28.62 ? 223 ASP H N   1 
ATOM   1600 C  CA  . ASP A 1 213 ? 26.234  58.107 84.476  1.00 29.64 ? 223 ASP H CA  1 
ATOM   1601 C  C   . ASP A 1 213 ? 26.562  59.267 85.407  1.00 32.40 ? 223 ASP H C   1 
ATOM   1602 O  O   . ASP A 1 213 ? 26.401  60.424 85.027  1.00 41.98 ? 223 ASP H O   1 
ATOM   1603 C  CB  . ASP A 1 213 ? 27.200  58.057 83.285  1.00 33.19 ? 223 ASP H CB  1 
ATOM   1604 C  CG  . ASP A 1 213 ? 26.885  56.987 82.261  1.00 36.32 ? 223 ASP H CG  1 
ATOM   1605 O  OD1 . ASP A 1 213 ? 26.863  55.785 82.610  1.00 33.51 ? 223 ASP H OD1 1 
ATOM   1606 O  OD2 . ASP A 1 213 ? 26.647  57.380 81.115  1.00 43.91 ? 223 ASP H OD2 1 
ATOM   1607 N  N   . LYS A 1 214 ? 27.042  58.945 86.611  1.00 26.50 ? 224 LYS H N   1 
ATOM   1608 C  CA  . LYS A 1 214 ? 27.344  59.955 87.601  1.00 25.77 ? 224 LYS H CA  1 
ATOM   1609 C  C   . LYS A 1 214 ? 28.812  59.801 87.990  1.00 23.52 ? 224 LYS H C   1 
ATOM   1610 O  O   . LYS A 1 214 ? 29.233  58.782 88.526  1.00 24.33 ? 224 LYS H O   1 
ATOM   1611 C  CB  . LYS A 1 214 ? 26.389  59.798 88.786  1.00 30.51 ? 224 LYS H CB  1 
ATOM   1612 C  CG  . LYS A 1 214 ? 26.457  60.919 89.803  1.00 34.23 ? 224 LYS H CG  1 
ATOM   1613 C  CD  . LYS A 1 214 ? 26.101  62.232 89.155  1.00 40.62 ? 224 LYS H CD  1 
ATOM   1614 C  CE  . LYS A 1 214 ? 25.286  63.150 90.027  1.00 48.07 ? 224 LYS H CE  1 
ATOM   1615 N  NZ  . LYS A 1 214 ? 24.530  64.124 89.198  1.00 51.81 ? 224 LYS H NZ  1 
ATOM   1616 N  N   . LYS A 1 215 ? 29.593  60.868 87.757  1.00 26.01 ? 225 LYS H N   1 
ATOM   1617 C  CA  . LYS A 1 215 ? 30.990  60.875 88.187  1.00 25.67 ? 225 LYS H CA  1 
ATOM   1618 C  C   . LYS A 1 215 ? 31.015  61.216 89.673  1.00 25.01 ? 225 LYS H C   1 
ATOM   1619 O  O   . LYS A 1 215 ? 30.349  62.160 90.073  1.00 27.83 ? 225 LYS H O   1 
ATOM   1620 C  CB  . LYS A 1 215 ? 31.774  61.929 87.389  1.00 30.08 ? 225 LYS H CB  1 
ATOM   1621 C  CG  . LYS A 1 215 ? 33.177  62.194 87.947  1.00 37.58 ? 225 LYS H CG  1 
ATOM   1622 C  CD  . LYS A 1 215 ? 34.238  62.654 86.949  1.00 49.36 ? 225 LYS H CD  1 
ATOM   1623 C  CE  . LYS A 1 215 ? 34.035  64.050 86.404  1.00 56.55 ? 225 LYS H CE  1 
ATOM   1624 N  NZ  . LYS A 1 215 ? 35.334  64.712 86.114  1.00 63.23 ? 225 LYS H NZ  1 
ATOM   1625 N  N   . VAL A 1 216 ? 31.833  60.509 90.468  1.00 23.16 ? 226 VAL H N   1 
ATOM   1626 C  CA  . VAL A 1 216 ? 31.884  60.700 91.906  1.00 23.23 ? 226 VAL H CA  1 
ATOM   1627 C  C   . VAL A 1 216 ? 33.252  61.293 92.237  1.00 24.88 ? 226 VAL H C   1 
ATOM   1628 O  O   . VAL A 1 216 ? 34.258  60.635 92.015  1.00 28.13 ? 226 VAL H O   1 
ATOM   1629 C  CB  . VAL A 1 216 ? 31.644  59.370 92.658  1.00 23.04 ? 226 VAL H CB  1 
ATOM   1630 C  CG1 . VAL A 1 216 ? 31.690  59.550 94.160  1.00 24.67 ? 226 VAL H CG1 1 
ATOM   1631 C  CG2 . VAL A 1 216 ? 30.317  58.754 92.230  1.00 25.21 ? 226 VAL H CG2 1 
ATOM   1632 N  N   . GLU A 1 217 ? 33.234  62.541 92.687  1.00 26.10 ? 227 GLU H N   1 
ATOM   1633 C  CA  . GLU A 1 217 ? 34.419  63.388 92.817  1.00 28.67 ? 227 GLU H CA  1 
ATOM   1634 C  C   . GLU A 1 217 ? 34.842  63.421 94.279  1.00 24.47 ? 227 GLU H C   1 
ATOM   1635 O  O   . GLU A 1 217 ? 33.993  63.512 95.171  1.00 25.52 ? 227 GLU H O   1 
ATOM   1636 C  CB  . GLU A 1 217 ? 34.082  64.849 92.486  1.00 34.64 ? 227 GLU H CB  1 
ATOM   1637 C  CG  . GLU A 1 217 ? 33.687  65.114 91.052  1.00 44.50 ? 227 GLU H CG  1 
ATOM   1638 C  CD  . GLU A 1 217 ? 34.812  65.629 90.171  1.00 55.43 ? 227 GLU H CD  1 
ATOM   1639 O  OE1 . GLU A 1 217 ? 35.905  65.907 90.705  1.00 65.21 ? 227 GLU H OE1 1 
ATOM   1640 O  OE2 . GLU A 1 217 ? 34.595  65.734 88.955  1.00 62.59 ? 227 GLU H OE2 1 
ATOM   1641 N  N   . PRO A 1 218 ? 36.154  63.408 94.583  1.00 26.46 ? 228 PRO H N   1 
ATOM   1642 C  CA  . PRO A 1 218 ? 36.611  63.411 95.963  1.00 31.28 ? 228 PRO H CA  1 
ATOM   1643 C  C   . PRO A 1 218 ? 36.367  64.739 96.657  1.00 36.24 ? 228 PRO H C   1 
ATOM   1644 O  O   . PRO A 1 218 ? 36.362  65.790 96.011  1.00 38.79 ? 228 PRO H O   1 
ATOM   1645 C  CB  . PRO A 1 218 ? 38.122  63.124 95.857  1.00 31.00 ? 228 PRO H CB  1 
ATOM   1646 C  CG  . PRO A 1 218 ? 38.292  62.477 94.530  1.00 33.17 ? 228 PRO H CG  1 
ATOM   1647 C  CD  . PRO A 1 218 ? 37.265  63.175 93.647  1.00 29.00 ? 228 PRO H CD  1 
ATOM   1648 N  N   . LYS A 1 219 ? 36.138  64.656 97.968  1.00 34.77 ? 229 LYS H N   1 
ATOM   1649 C  CA  . LYS A 1 219 ? 36.213  65.802 98.861  1.00 41.20 ? 229 LYS H CA  1 
ATOM   1650 C  C   . LYS A 1 219 ? 37.629  65.991 99.432  1.00 45.99 ? 229 LYS H C   1 
ATOM   1651 O  O   . LYS A 1 219 ? 38.331  65.018 99.765  1.00 40.10 ? 229 LYS H O   1 
ATOM   1652 C  CB  . LYS A 1 219 ? 35.236  65.564 100.015 1.00 41.88 ? 229 LYS H CB  1 
ATOM   1653 C  CG  . LYS A 1 219 ? 33.800  65.290 99.611  1.00 46.94 ? 229 LYS H CG  1 
ATOM   1654 C  CD  . LYS A 1 219 ? 33.126  66.453 98.936  1.00 54.70 ? 229 LYS H CD  1 
ATOM   1655 C  CE  . LYS A 1 219 ? 31.626  66.403 99.136  1.00 54.74 ? 229 LYS H CE  1 
ATOM   1656 N  NZ  . LYS A 1 219 ? 30.968  67.615 98.599  1.00 63.52 ? 229 LYS H NZ  1 
ATOM   1657 N  N   . SER A 1 220 ? 38.004  67.269 99.632  1.00 49.98 ? 230 SER H N   1 
ATOM   1658 C  CA  . SER A 1 220 ? 39.212  67.664 100.356 1.00 57.98 ? 230 SER H CA  1 
ATOM   1659 C  C   . SER A 1 220 ? 39.196  67.198 101.824 1.00 58.50 ? 230 SER H C   1 
ATOM   1660 O  O   . SER A 1 220 ? 38.132  67.303 102.482 1.00 58.77 ? 230 SER H O   1 
ATOM   1661 C  CB  . SER A 1 220 ? 39.394  69.163 100.280 1.00 60.10 ? 230 SER H CB  1 
ATOM   1662 O  OG  . SER A 1 220 ? 39.677  69.560 98.947  1.00 63.46 ? 230 SER H OG  1 
ATOM   1663 N  N   . GLU B 2 1   ? -2.632  17.634 97.288  1.00 30.59 ? 1   GLU L N   1 
ATOM   1664 C  CA  . GLU B 2 1   ? -1.309  18.308 97.276  1.00 28.96 ? 1   GLU L CA  1 
ATOM   1665 C  C   . GLU B 2 1   ? -0.380  17.550 98.216  1.00 26.77 ? 1   GLU L C   1 
ATOM   1666 O  O   . GLU B 2 1   ? -0.770  17.306 99.356  1.00 27.39 ? 1   GLU L O   1 
ATOM   1667 C  CB  . GLU B 2 1   ? -1.476  19.739 97.776  1.00 33.17 ? 1   GLU L CB  1 
ATOM   1668 C  CG  . GLU B 2 1   ? -0.176  20.466 97.997  1.00 35.58 ? 1   GLU L CG  1 
ATOM   1669 C  CD  . GLU B 2 1   ? -0.322  21.906 98.440  1.00 37.83 ? 1   GLU L CD  1 
ATOM   1670 O  OE1 . GLU B 2 1   ? 0.113   22.801 97.698  1.00 44.22 ? 1   GLU L OE1 1 
ATOM   1671 O  OE2 . GLU B 2 1   ? -0.832  22.114 99.522  1.00 44.51 ? 1   GLU L OE2 1 
ATOM   1672 N  N   . ILE B 2 2   ? 0.833   17.212 97.739  1.00 21.31 ? 2   ILE L N   1 
ATOM   1673 C  CA  . ILE B 2 2   ? 1.890   16.687 98.591  1.00 20.52 ? 2   ILE L CA  1 
ATOM   1674 C  C   . ILE B 2 2   ? 2.576   17.871 99.240  1.00 22.72 ? 2   ILE L C   1 
ATOM   1675 O  O   . ILE B 2 2   ? 3.149   18.715 98.530  1.00 25.76 ? 2   ILE L O   1 
ATOM   1676 C  CB  . ILE B 2 2   ? 2.899   15.820 97.815  1.00 19.95 ? 2   ILE L CB  1 
ATOM   1677 C  CG1 . ILE B 2 2   ? 2.215   14.638 97.114  1.00 22.21 ? 2   ILE L CG1 1 
ATOM   1678 C  CG2 . ILE B 2 2   ? 4.032   15.296 98.697  1.00 22.76 ? 2   ILE L CG2 1 
ATOM   1679 C  CD1 . ILE B 2 2   ? 3.082   13.733 96.310  1.00 21.92 ? 2   ILE L CD1 1 
ATOM   1680 N  N   . VAL B 2 3   ? 2.565   17.925 100.577 1.00 19.01 ? 3   VAL L N   1 
ATOM   1681 C  CA  . VAL B 2 3   ? 3.224   19.009 101.245 1.00 18.36 ? 3   VAL L CA  1 
ATOM   1682 C  C   . VAL B 2 3   ? 4.638   18.601 101.614 1.00 18.15 ? 3   VAL L C   1 
ATOM   1683 O  O   . VAL B 2 3   ? 4.817   17.512 102.156 1.00 18.34 ? 3   VAL L O   1 
ATOM   1684 C  CB  . VAL B 2 3   ? 2.472   19.399 102.523 1.00 21.66 ? 3   VAL L CB  1 
ATOM   1685 C  CG1 . VAL B 2 3   ? 3.206   20.495 103.248 1.00 22.57 ? 3   VAL L CG1 1 
ATOM   1686 C  CG2 . VAL B 2 3   ? 1.036   19.770 102.201 1.00 22.35 ? 3   VAL L CG2 1 
ATOM   1687 N  N   . LEU B 2 4   ? 5.623   19.434 101.234 1.00 17.26 ? 4   LEU L N   1 
ATOM   1688 C  CA  . LEU B 2 4   ? 7.014   19.182 101.596 1.00 17.23 ? 4   LEU L CA  1 
ATOM   1689 C  C   . LEU B 2 4   ? 7.410   20.165 102.683 1.00 15.82 ? 4   LEU L C   1 
ATOM   1690 O  O   . LEU B 2 4   ? 7.243   21.379 102.557 1.00 18.62 ? 4   LEU L O   1 
ATOM   1691 C  CB  . LEU B 2 4   ? 7.988   19.360 100.413 1.00 16.65 ? 4   LEU L CB  1 
ATOM   1692 C  CG  . LEU B 2 4   ? 7.706   18.439 99.212  1.00 17.67 ? 4   LEU L CG  1 
ATOM   1693 C  CD1 . LEU B 2 4   ? 8.745   18.642 98.111  1.00 18.24 ? 4   LEU L CD1 1 
ATOM   1694 C  CD2 . LEU B 2 4   ? 7.687   16.999 99.630  1.00 18.14 ? 4   LEU L CD2 1 
ATOM   1695 N  N   . THR B 2 5   ? 7.920   19.582 103.776 1.00 14.89 ? 5   THR L N   1 
ATOM   1696 C  CA  . THR B 2 5   ? 8.381   20.323 104.938 1.00 16.52 ? 5   THR L CA  1 
ATOM   1697 C  C   . THR B 2 5   ? 9.889   20.154 105.071 1.00 18.49 ? 5   THR L C   1 
ATOM   1698 O  O   . THR B 2 5   ? 10.383  19.050 105.331 1.00 17.98 ? 5   THR L O   1 
ATOM   1699 C  CB  . THR B 2 5   ? 7.680   19.878 106.226 1.00 19.95 ? 5   THR L CB  1 
ATOM   1700 O  OG1 . THR B 2 5   ? 6.279   20.097 106.054 1.00 23.36 ? 5   THR L OG1 1 
ATOM   1701 C  CG2 . THR B 2 5   ? 8.141   20.722 107.389 1.00 21.49 ? 5   THR L CG2 1 
ATOM   1702 N  N   . GLN B 2 6   ? 10.611  21.272 104.957 1.00 16.33 ? 6   GLN L N   1 
ATOM   1703 C  CA  . GLN B 2 6   ? 12.056  21.271 105.076 1.00 16.47 ? 6   GLN L CA  1 
ATOM   1704 C  C   . GLN B 2 6   ? 12.449  21.654 106.499 1.00 16.45 ? 6   GLN L C   1 
ATOM   1705 O  O   . GLN B 2 6   ? 11.769  22.417 107.191 1.00 18.17 ? 6   GLN L O   1 
ATOM   1706 C  CB  . GLN B 2 6   ? 12.697  22.233 104.074 1.00 14.91 ? 6   GLN L CB  1 
ATOM   1707 C  CG  . GLN B 2 6   ? 12.618  21.706 102.644 1.00 14.87 ? 6   GLN L CG  1 
ATOM   1708 C  CD  . GLN B 2 6   ? 13.315  22.570 101.623 1.00 15.02 ? 6   GLN L CD  1 
ATOM   1709 O  OE1 . GLN B 2 6   ? 12.709  23.209 100.763 1.00 15.40 ? 6   GLN L OE1 1 
ATOM   1710 N  NE2 . GLN B 2 6   ? 14.617  22.609 101.757 1.00 15.20 ? 6   GLN L NE2 1 
ATOM   1711 N  N   . SER B 2 7   ? 13.541  21.043 106.936 1.00 14.91 ? 7   SER L N   1 
ATOM   1712 C  CA  A SER B 2 7   ? 14.171  21.301 108.226 0.25 15.51 ? 7   SER L CA  1 
ATOM   1713 C  CA  B SER B 2 7   ? 14.178  21.401 108.187 0.25 14.34 ? 7   SER L CA  1 
ATOM   1714 C  CA  C SER B 2 7   ? 14.175  21.290 108.225 0.50 16.72 ? 7   SER L CA  1 
ATOM   1715 C  C   . SER B 2 7   ? 15.682  21.239 108.021 1.00 16.20 ? 7   SER L C   1 
ATOM   1716 O  O   . SER B 2 7   ? 16.143  20.417 107.232 1.00 15.46 ? 7   SER L O   1 
ATOM   1717 C  CB  A SER B 2 7   ? 13.740  20.276 109.262 0.25 15.56 ? 7   SER L CB  1 
ATOM   1718 C  CB  B SER B 2 7   ? 13.673  20.572 109.329 0.25 13.02 ? 7   SER L CB  1 
ATOM   1719 C  CB  C SER B 2 7   ? 13.838  20.231 109.236 0.50 18.50 ? 7   SER L CB  1 
ATOM   1720 O  OG  A SER B 2 7   ? 14.298  20.518 110.556 0.25 15.19 ? 7   SER L OG  1 
ATOM   1721 O  OG  B SER B 2 7   ? 13.855  19.179 109.067 0.25 11.22 ? 7   SER L OG  1 
ATOM   1722 O  OG  C SER B 2 7   ? 12.461  20.262 109.555 0.50 22.68 ? 7   SER L OG  1 
ATOM   1723 N  N   . PRO B 2 8   ? 16.492  22.047 108.721 1.00 17.11 ? 8   PRO L N   1 
ATOM   1724 C  CA  . PRO B 2 8   ? 16.075  23.183 109.547 1.00 17.31 ? 8   PRO L CA  1 
ATOM   1725 C  C   . PRO B 2 8   ? 15.676  24.328 108.614 1.00 16.57 ? 8   PRO L C   1 
ATOM   1726 O  O   . PRO B 2 8   ? 15.944  24.279 107.422 1.00 18.50 ? 8   PRO L O   1 
ATOM   1727 C  CB  . PRO B 2 8   ? 17.358  23.545 110.306 1.00 14.98 ? 8   PRO L CB  1 
ATOM   1728 C  CG  . PRO B 2 8   ? 18.441  23.189 109.363 1.00 17.21 ? 8   PRO L CG  1 
ATOM   1729 C  CD  . PRO B 2 8   ? 17.949  21.927 108.683 1.00 17.74 ? 8   PRO L CD  1 
ATOM   1730 N  N   . GLY B 2 9   ? 15.063  25.373 109.143 1.00 17.37 ? 9   GLY L N   1 
ATOM   1731 C  CA  . GLY B 2 9   ? 14.746  26.525 108.318 1.00 17.50 ? 9   GLY L CA  1 
ATOM   1732 C  C   . GLY B 2 9   ? 16.015  27.322 108.015 1.00 16.18 ? 9   GLY L C   1 
ATOM   1733 O  O   . GLY B 2 9   ? 16.112  27.966 106.974 1.00 17.29 ? 9   GLY L O   1 
ATOM   1734 N  N   . THR B 2 10  ? 16.932  27.364 109.000 1.00 16.78 ? 10  THR L N   1 
ATOM   1735 C  CA  . THR B 2 10  ? 18.185  28.064 108.853 1.00 17.05 ? 10  THR L CA  1 
ATOM   1736 C  C   . THR B 2 10  ? 19.296  27.213 109.436 1.00 15.20 ? 10  THR L C   1 
ATOM   1737 O  O   . THR B 2 10  ? 19.063  26.469 110.384 1.00 16.67 ? 10  THR L O   1 
ATOM   1738 C  CB  . THR B 2 10  ? 18.215  29.443 109.534 1.00 19.69 ? 10  THR L CB  1 
ATOM   1739 O  OG1 . THR B 2 10  ? 18.000  29.333 110.936 1.00 21.91 ? 10  THR L OG1 1 
ATOM   1740 C  CG2 . THR B 2 10  ? 17.164  30.359 108.979 1.00 20.83 ? 10  THR L CG2 1 
ATOM   1741 N  N   . LEU B 2 11  ? 20.483  27.318 108.831 1.00 14.98 ? 11  LEU L N   1 
ATOM   1742 C  CA  . LEU B 2 11  ? 21.635  26.498 109.185 1.00 15.17 ? 11  LEU L CA  1 
ATOM   1743 C  C   . LEU B 2 11  ? 22.884  27.338 108.957 1.00 16.16 ? 11  LEU L C   1 
ATOM   1744 O  O   . LEU B 2 11  ? 23.031  28.003 107.915 1.00 16.66 ? 11  LEU L O   1 
ATOM   1745 C  CB  . LEU B 2 11  ? 21.669  25.288 108.250 1.00 15.53 ? 11  LEU L CB  1 
ATOM   1746 C  CG  . LEU B 2 11  ? 22.697  24.204 108.521 1.00 16.76 ? 11  LEU L CG  1 
ATOM   1747 C  CD1 . LEU B 2 11  ? 22.662  23.695 109.955 1.00 16.93 ? 11  LEU L CD1 1 
ATOM   1748 C  CD2 . LEU B 2 11  ? 22.486  23.056 107.540 1.00 17.63 ? 11  LEU L CD2 1 
ATOM   1749 N  N   . SER B 2 12  ? 23.786  27.376 109.959 1.00 14.66 ? 12  SER L N   1 
ATOM   1750 C  CA  . SER B 2 12  ? 25.028  28.098 109.882 1.00 14.09 ? 12  SER L CA  1 
ATOM   1751 C  C   . SER B 2 12  ? 26.185  27.168 110.255 1.00 14.56 ? 12  SER L C   1 
ATOM   1752 O  O   . SER B 2 12  ? 26.238  26.653 111.369 1.00 16.28 ? 12  SER L O   1 
ATOM   1753 C  CB  . SER B 2 12  ? 24.975  29.275 110.859 1.00 16.05 ? 12  SER L CB  1 
ATOM   1754 O  OG  . SER B 2 12  ? 26.201  29.988 110.806 1.00 19.24 ? 12  SER L OG  1 
ATOM   1755 N  N   . LEU B 2 13  ? 27.065  26.907 109.296 1.00 13.23 ? 13  LEU L N   1 
ATOM   1756 C  CA  . LEU B 2 13  ? 28.157  25.920 109.445 1.00 13.81 ? 13  LEU L CA  1 
ATOM   1757 C  C   . LEU B 2 13  ? 29.402  26.449 108.741 1.00 14.30 ? 13  LEU L C   1 
ATOM   1758 O  O   . LEU B 2 13  ? 29.321  27.241 107.798 1.00 15.07 ? 13  LEU L O   1 
ATOM   1759 C  CB  . LEU B 2 13  ? 27.757  24.557 108.851 1.00 14.20 ? 13  LEU L CB  1 
ATOM   1760 C  CG  . LEU B 2 13  ? 26.605  23.794 109.518 1.00 15.30 ? 13  LEU L CG  1 
ATOM   1761 C  CD1 . LEU B 2 13  ? 26.207  22.623 108.634 1.00 17.44 ? 13  LEU L CD1 1 
ATOM   1762 C  CD2 . LEU B 2 13  ? 27.020  23.336 110.926 1.00 16.07 ? 13  LEU L CD2 1 
ATOM   1763 N  N   . SER B 2 14  ? 30.592  26.010 109.209 1.00 15.24 ? 14  SER L N   1 
ATOM   1764 C  CA  . SER B 2 14  ? 31.868  26.483 108.733 1.00 14.53 ? 14  SER L CA  1 
ATOM   1765 C  C   . SER B 2 14  ? 32.387  25.690 107.562 1.00 14.75 ? 14  SER L C   1 
ATOM   1766 O  O   . SER B 2 14  ? 32.007  24.550 107.385 1.00 15.80 ? 14  SER L O   1 
ATOM   1767 C  CB  . SER B 2 14  ? 32.896  26.359 109.864 1.00 17.67 ? 14  SER L CB  1 
ATOM   1768 O  OG  . SER B 2 14  ? 32.553  27.238 110.911 1.00 20.05 ? 14  SER L OG  1 
ATOM   1769 N  N   . PRO B 2 15  ? 33.324  26.253 106.747 1.00 15.14 ? 15  PRO L N   1 
ATOM   1770 C  CA  . PRO B 2 15  ? 33.980  25.430 105.744 1.00 17.70 ? 15  PRO L CA  1 
ATOM   1771 C  C   . PRO B 2 15  ? 34.530  24.155 106.377 1.00 16.03 ? 15  PRO L C   1 
ATOM   1772 O  O   . PRO B 2 15  ? 35.140  24.207 107.466 1.00 17.67 ? 15  PRO L O   1 
ATOM   1773 C  CB  . PRO B 2 15  ? 35.035  26.388 105.201 1.00 18.09 ? 15  PRO L CB  1 
ATOM   1774 C  CG  . PRO B 2 15  ? 34.437  27.762 105.409 1.00 17.83 ? 15  PRO L CG  1 
ATOM   1775 C  CD  . PRO B 2 15  ? 33.768  27.653 106.763 1.00 17.67 ? 15  PRO L CD  1 
ATOM   1776 N  N   . GLY B 2 16  ? 34.335  23.026 105.679 1.00 15.77 ? 16  GLY L N   1 
ATOM   1777 C  CA  . GLY B 2 16  ? 34.821  21.732 106.139 1.00 15.05 ? 16  GLY L CA  1 
ATOM   1778 C  C   . GLY B 2 16  ? 33.741  20.952 106.879 1.00 16.76 ? 16  GLY L C   1 
ATOM   1779 O  O   . GLY B 2 16  ? 33.836  19.726 106.963 1.00 17.07 ? 16  GLY L O   1 
ATOM   1780 N  N   . ASP B 2 17  ? 32.763  21.650 107.432 1.00 15.58 ? 17  ASP L N   1 
ATOM   1781 C  CA  . ASP B 2 17  ? 31.660  20.994 108.111 1.00 15.77 ? 17  ASP L CA  1 
ATOM   1782 C  C   . ASP B 2 17  ? 30.756  20.256 107.116 1.00 15.57 ? 17  ASP L C   1 
ATOM   1783 O  O   . ASP B 2 17  ? 30.731  20.602 105.927 1.00 15.92 ? 17  ASP L O   1 
ATOM   1784 C  CB  . ASP B 2 17  ? 30.822  21.975 108.915 1.00 14.88 ? 17  ASP L CB  1 
ATOM   1785 C  CG  . ASP B 2 17  ? 31.509  22.641 110.102 1.00 17.24 ? 17  ASP L CG  1 
ATOM   1786 O  OD1 . ASP B 2 17  ? 32.631  22.208 110.462 1.00 17.93 ? 17  ASP L OD1 1 
ATOM   1787 O  OD2 . ASP B 2 17  ? 30.879  23.648 110.660 1.00 16.11 ? 17  ASP L OD2 1 
ATOM   1788 N  N   . ARG B 2 18  ? 30.069  19.228 107.593 1.00 14.20 ? 18  ARG L N   1 
ATOM   1789 C  CA  . ARG B 2 18  ? 29.095  18.481 106.811 1.00 13.74 ? 18  ARG L CA  1 
ATOM   1790 C  C   . ARG B 2 18  ? 27.704  19.069 107.077 1.00 14.25 ? 18  ARG L C   1 
ATOM   1791 O  O   . ARG B 2 18  ? 27.239  19.162 108.231 1.00 14.72 ? 18  ARG L O   1 
ATOM   1792 C  CB  . ARG B 2 18  ? 29.079  17.030 107.286 1.00 14.74 ? 18  ARG L CB  1 
ATOM   1793 C  CG  . ARG B 2 18  ? 28.042  16.145 106.595 1.00 15.94 ? 18  ARG L CG  1 
ATOM   1794 C  CD  . ARG B 2 18  ? 28.090  14.724 107.120 1.00 14.58 ? 18  ARG L CD  1 
ATOM   1795 N  NE  . ARG B 2 18  ? 27.053  13.884 106.528 1.00 15.76 ? 18  ARG L NE  1 
ATOM   1796 C  CZ  . ARG B 2 18  ? 27.226  13.126 105.449 1.00 14.33 ? 18  ARG L CZ  1 
ATOM   1797 N  NH1 . ARG B 2 18  ? 28.353  13.179 104.755 1.00 15.75 ? 18  ARG L NH1 1 
ATOM   1798 N  NH2 . ARG B 2 18  ? 26.225  12.373 105.010 1.00 16.84 ? 18  ARG L NH2 1 
ATOM   1799 N  N   . ALA B 2 19  ? 27.017  19.493 106.007 1.00 14.00 ? 19  ALA L N   1 
ATOM   1800 C  CA  . ALA B 2 19  ? 25.691  20.056 106.123 1.00 13.72 ? 19  ALA L CA  1 
ATOM   1801 C  C   . ALA B 2 19  ? 24.628  19.060 105.667 1.00 14.28 ? 19  ALA L C   1 
ATOM   1802 O  O   . ALA B 2 19  ? 24.845  18.432 104.630 1.00 16.23 ? 19  ALA L O   1 
ATOM   1803 C  CB  . ALA B 2 19  ? 25.621  21.296 105.265 1.00 14.89 ? 19  ALA L CB  1 
ATOM   1804 N  N   . THR B 2 20  ? 23.560  18.913 106.446 1.00 13.05 ? 20  THR L N   1 
ATOM   1805 C  CA  . THR B 2 20  ? 22.439  18.038 106.159 1.00 13.08 ? 20  THR L CA  1 
ATOM   1806 C  C   . THR B 2 20  ? 21.148  18.866 106.136 1.00 15.52 ? 20  THR L C   1 
ATOM   1807 O  O   . THR B 2 20  ? 20.781  19.541 107.116 1.00 17.03 ? 20  THR L O   1 
ATOM   1808 C  CB  . THR B 2 20  ? 22.319  16.905 107.185 1.00 14.13 ? 20  THR L CB  1 
ATOM   1809 O  OG1 . THR B 2 20  ? 23.552  16.195 107.294 1.00 15.19 ? 20  THR L OG1 1 
ATOM   1810 C  CG2 . THR B 2 20  ? 21.206  15.944 106.875 1.00 16.58 ? 20  THR L CG2 1 
ATOM   1811 N  N   . HIS B 2 21  ? 20.448  18.738 105.005 1.00 14.64 ? 21  HIS L N   1 
ATOM   1812 C  CA  . HIS B 2 21  ? 19.195  19.410 104.734 1.00 13.27 ? 21  HIS L CA  1 
ATOM   1813 C  C   . HIS B 2 21  ? 18.107  18.357 104.540 1.00 13.85 ? 21  HIS L C   1 
ATOM   1814 O  O   . HIS B 2 21  ? 18.303  17.434 103.769 1.00 15.37 ? 21  HIS L O   1 
ATOM   1815 C  CB  . HIS B 2 21  ? 19.280  20.323 103.494 1.00 12.88 ? 21  HIS L CB  1 
ATOM   1816 C  CG  . HIS B 2 21  ? 20.474  21.173 103.381 1.00 15.17 ? 21  HIS L CG  1 
ATOM   1817 N  ND1 . HIS B 2 21  ? 21.723  20.740 102.988 1.00 16.18 ? 21  HIS L ND1 1 
ATOM   1818 C  CD2 . HIS B 2 21  ? 20.610  22.485 103.641 1.00 18.87 ? 21  HIS L CD2 1 
ATOM   1819 C  CE1 . HIS B 2 21  ? 22.542  21.790 102.990 1.00 16.90 ? 21  HIS L CE1 1 
ATOM   1820 N  NE2 . HIS B 2 21  ? 21.891  22.850 103.375 1.00 19.00 ? 21  HIS L NE2 1 
ATOM   1821 N  N   . SER B 2 22  ? 17.071  18.396 105.365 1.00 13.14 ? 22  SER L N   1 
ATOM   1822 C  CA  . SER B 2 22  ? 15.996  17.408 105.306 1.00 15.05 ? 22  SER L CA  1 
ATOM   1823 C  C   . SER B 2 22  ? 14.745  17.920 104.591 1.00 14.88 ? 22  SER L C   1 
ATOM   1824 O  O   . SER B 2 22  ? 14.391  19.083 104.722 1.00 16.34 ? 22  SER L O   1 
ATOM   1825 C  CB  . SER B 2 22  ? 15.604  16.980 106.686 1.00 17.80 ? 22  SER L CB  1 
ATOM   1826 O  OG  . SER B 2 22  ? 16.676  16.306 107.328 1.00 22.73 ? 22  SER L OG  1 
ATOM   1827 N  N   . CYS B 2 23  ? 14.028  16.996 103.936 1.00 15.13 ? 23  CYS L N   1 
ATOM   1828 C  CA  . CYS B 2 23  ? 12.780  17.257 103.225 1.00 15.68 ? 23  CYS L CA  1 
ATOM   1829 C  C   . CYS B 2 23  ? 11.828  16.123 103.528 1.00 17.42 ? 23  CYS L C   1 
ATOM   1830 O  O   . CYS B 2 23  ? 12.137  15.000 103.130 1.00 17.63 ? 23  CYS L O   1 
ATOM   1831 C  CB  . CYS B 2 23  ? 13.124  17.387 101.749 1.00 15.33 ? 23  CYS L CB  1 
ATOM   1832 S  SG  . CYS B 2 23  ? 11.671  17.738 100.697 1.00 18.47 ? 23  CYS L SG  1 
ATOM   1833 N  N   . ARG B 2 24  ? 10.728  16.404 104.229 1.00 16.12 ? 24  ARG L N   1 
ATOM   1834 C  CA  . ARG B 2 24  ? 9.736   15.403 104.577 1.00 17.49 ? 24  ARG L CA  1 
ATOM   1835 C  C   . ARG B 2 24  ? 8.507   15.647 103.700 1.00 17.70 ? 24  ARG L C   1 
ATOM   1836 O  O   . ARG B 2 24  ? 8.016   16.777 103.594 1.00 19.77 ? 24  ARG L O   1 
ATOM   1837 C  CB  . ARG B 2 24  ? 9.349   15.495 106.056 1.00 19.30 ? 24  ARG L CB  1 
ATOM   1838 C  CG  . ARG B 2 24  ? 10.434  15.028 107.007 1.00 23.45 ? 24  ARG L CG  1 
ATOM   1839 C  CD  . ARG B 2 24  ? 10.058  15.087 108.485 1.00 27.88 ? 24  ARG L CD  1 
ATOM   1840 N  NE  . ARG B 2 24  ? 11.023  14.300 109.250 1.00 29.33 ? 24  ARG L NE  1 
ATOM   1841 C  CZ  . ARG B 2 24  ? 12.224  14.741 109.594 1.00 33.43 ? 24  ARG L CZ  1 
ATOM   1842 N  NH1 . ARG B 2 24  ? 12.630  15.940 109.194 1.00 34.92 ? 24  ARG L NH1 1 
ATOM   1843 N  NH2 . ARG B 2 24  ? 13.007  13.995 110.356 1.00 30.46 ? 24  ARG L NH2 1 
ATOM   1844 N  N   . ALA B 2 25  ? 7.894   14.562 103.210 1.00 19.84 ? 25  ALA L N   1 
ATOM   1845 C  CA  . ALA B 2 25  ? 6.667   14.678 102.423 1.00 18.18 ? 25  ALA L CA  1 
ATOM   1846 C  C   . ALA B 2 25  ? 5.434   14.145 103.165 1.00 19.96 ? 25  ALA L C   1 
ATOM   1847 O  O   . ALA B 2 25  ? 5.534   13.181 103.926 1.00 21.54 ? 25  ALA L O   1 
ATOM   1848 C  CB  . ALA B 2 25  ? 6.845   13.943 101.141 1.00 18.56 ? 25  ALA L CB  1 
ATOM   1849 N  N   . SER B 2 26  ? 4.278   14.751 102.890 1.00 19.99 ? 26  SER L N   1 
ATOM   1850 C  CA  . SER B 2 26  ? 3.043   14.395 103.602 1.00 20.24 ? 26  SER L CA  1 
ATOM   1851 C  C   . SER B 2 26  ? 2.479   13.077 103.089 1.00 23.54 ? 26  SER L C   1 
ATOM   1852 O  O   . SER B 2 26  ? 1.664   12.464 103.771 1.00 25.95 ? 26  SER L O   1 
ATOM   1853 C  CB  . SER B 2 26  ? 2.034   15.496 103.556 1.00 20.27 ? 26  SER L CB  1 
ATOM   1854 O  OG  . SER B 2 26  ? 1.640   15.737 102.204 1.00 20.88 ? 26  SER L OG  1 
ATOM   1855 N  N   . GLN B 2 27  ? 2.919   12.652 101.927 1.00 21.02 ? 27  GLN L N   1 
ATOM   1856 C  CA  . GLN B 2 27  ? 2.656   11.310 101.439 1.00 26.74 ? 27  GLN L CA  1 
ATOM   1857 C  C   . GLN B 2 27  ? 3.862   10.867 100.640 1.00 23.55 ? 27  GLN L C   1 
ATOM   1858 O  O   . GLN B 2 27  ? 4.708   11.689 100.297 1.00 23.21 ? 27  GLN L O   1 
ATOM   1859 C  CB  . GLN B 2 27  ? 1.328   11.223 100.697 1.00 33.32 ? 27  GLN L CB  1 
ATOM   1860 C  CG  . GLN B 2 27  ? 1.188   12.205 99.567  1.00 33.34 ? 27  GLN L CG  1 
ATOM   1861 C  CD  . GLN B 2 27  ? -0.127  12.113 98.824  1.00 33.19 ? 27  GLN L CD  1 
ATOM   1862 O  OE1 . GLN B 2 27  ? -0.331  11.253 97.977  1.00 40.74 ? 27  GLN L OE1 1 
ATOM   1863 N  NE2 . GLN B 2 27  ? -0.993  13.064 99.084  1.00 31.95 ? 27  GLN L NE2 1 
ATOM   1864 N  N   . SER B 2 28  ? 3.901   9.591  100.261 1.00 23.70 ? 28  SER L N   1 
ATOM   1865 C  CA  A SER B 2 28  ? 5.043   8.998  99.600  0.50 24.87 ? 28  SER L CA  1 
ATOM   1866 C  CA  B SER B 2 28  ? 5.065   9.027  99.613  0.50 25.90 ? 28  SER L CA  1 
ATOM   1867 C  C   . SER B 2 28  ? 5.232   9.620  98.222  1.00 25.68 ? 28  SER L C   1 
ATOM   1868 O  O   . SER B 2 28  ? 4.238   9.805  97.500  1.00 24.34 ? 28  SER L O   1 
ATOM   1869 C  CB  A SER B 2 28  ? 4.892   7.487  99.507  0.50 26.35 ? 28  SER L CB  1 
ATOM   1870 C  CB  B SER B 2 28  ? 5.015   7.518  99.572  0.50 28.52 ? 28  SER L CB  1 
ATOM   1871 O  OG  A SER B 2 28  ? 6.058   6.885  98.974  0.50 26.69 ? 28  SER L OG  1 
ATOM   1872 O  OG  B SER B 2 28  ? 5.087   7.001  100.887 0.50 32.32 ? 28  SER L OG  1 
ATOM   1873 N  N   . VAL B 2 29  ? 6.500   9.946  97.906  1.00 21.83 ? 29  VAL L N   1 
ATOM   1874 C  CA  . VAL B 2 29  ? 6.923   10.429 96.606  1.00 22.55 ? 29  VAL L CA  1 
ATOM   1875 C  C   . VAL B 2 29  ? 7.520   9.263  95.837  1.00 29.91 ? 29  VAL L C   1 
ATOM   1876 O  O   . VAL B 2 29  ? 8.595   8.804  96.212  1.00 31.34 ? 29  VAL L O   1 
ATOM   1877 C  CB  . VAL B 2 29  ? 7.924   11.585 96.764  1.00 20.39 ? 29  VAL L CB  1 
ATOM   1878 C  CG1 . VAL B 2 29  ? 8.535   12.002 95.457  1.00 20.32 ? 29  VAL L CG1 1 
ATOM   1879 C  CG2 . VAL B 2 29  ? 7.234   12.757 97.457  1.00 22.66 ? 29  VAL L CG2 1 
ATOM   1880 N  N   . SER B 2 30  ? 6.786   8.846  94.799  1.00 35.68 ? 30  SER L N   1 
ATOM   1881 C  CA  . SER B 2 30  ? 7.098   7.681  93.974  1.00 43.60 ? 30  SER L CA  1 
ATOM   1882 C  C   . SER B 2 30  ? 8.183   8.057  92.976  1.00 37.33 ? 30  SER L C   1 
ATOM   1883 O  O   . SER B 2 30  ? 8.331   9.238  92.620  1.00 41.18 ? 30  SER L O   1 
ATOM   1884 C  CB  . SER B 2 30  ? 5.889   7.153  93.204  1.00 45.81 ? 30  SER L CB  1 
ATOM   1885 O  OG  . SER B 2 30  ? 4.737   7.049  94.021  1.00 46.08 ? 30  SER L OG  1 
ATOM   1886 N  N   . ARG B 2 31  ? 8.913   7.030  92.541  1.00 36.48 ? 36  ARG L N   1 
ATOM   1887 C  CA  . ARG B 2 31  ? 9.846   7.083  91.438  1.00 42.25 ? 36  ARG L CA  1 
ATOM   1888 C  C   . ARG B 2 31  ? 11.026  7.976  91.833  1.00 40.72 ? 36  ARG L C   1 
ATOM   1889 O  O   . ARG B 2 31  ? 11.815  8.396  90.972  1.00 43.19 ? 36  ARG L O   1 
ATOM   1890 C  CB  . ARG B 2 31  ? 9.042   7.449  90.177  1.00 51.53 ? 36  ARG L CB  1 
ATOM   1891 C  CG  . ARG B 2 31  ? 7.850   6.517  89.930  1.00 58.87 ? 36  ARG L CG  1 
ATOM   1892 C  CD  . ARG B 2 31  ? 6.896   6.842  88.772  1.00 62.43 ? 36  ARG L CD  1 
ATOM   1893 N  NE  . ARG B 2 31  ? 6.168   8.102  88.937  1.00 64.81 ? 36  ARG L NE  1 
ATOM   1894 C  CZ  . ARG B 2 31  ? 5.428   8.685  87.992  1.00 63.57 ? 36  ARG L CZ  1 
ATOM   1895 N  NH1 . ARG B 2 31  ? 5.008   9.937  88.133  1.00 49.34 ? 36  ARG L NH1 1 
ATOM   1896 N  NH2 . ARG B 2 31  ? 5.171   8.031  86.872  1.00 65.06 ? 36  ARG L NH2 1 
ATOM   1897 N  N   . SER B 2 32  ? 11.146  8.245  93.150  1.00 46.82 ? 37  SER L N   1 
ATOM   1898 C  CA  . SER B 2 32  ? 12.194  9.120  93.644  1.00 41.27 ? 37  SER L CA  1 
ATOM   1899 C  C   . SER B 2 32  ? 12.259  10.414 92.824  1.00 34.37 ? 37  SER L C   1 
ATOM   1900 O  O   . SER B 2 32  ? 13.373  10.881 92.610  1.00 30.04 ? 37  SER L O   1 
ATOM   1901 C  CB  . SER B 2 32  ? 13.523  8.425  93.587  1.00 48.48 ? 37  SER L CB  1 
ATOM   1902 O  OG  . SER B 2 32  ? 13.544  7.238  94.377  1.00 48.70 ? 37  SER L OG  1 
ATOM   1903 N  N   . TYR B 2 33  ? 11.108  10.938 92.339  1.00 26.78 ? 38  TYR L N   1 
ATOM   1904 C  CA  . TYR B 2 33  ? 10.980  12.188 91.584  1.00 21.63 ? 38  TYR L CA  1 
ATOM   1905 C  C   . TYR B 2 33  ? 11.020  13.355 92.568  1.00 18.22 ? 38  TYR L C   1 
ATOM   1906 O  O   . TYR B 2 33  ? 10.045  14.036 92.851  1.00 17.89 ? 38  TYR L O   1 
ATOM   1907 C  CB  . TYR B 2 33  ? 9.682   12.158 90.782  1.00 25.92 ? 38  TYR L CB  1 
ATOM   1908 C  CG  . TYR B 2 33  ? 9.785   11.361 89.502  1.00 27.74 ? 38  TYR L CG  1 
ATOM   1909 C  CD1 . TYR B 2 33  ? 11.004  11.171 88.863  1.00 36.21 ? 38  TYR L CD1 1 
ATOM   1910 C  CD2 . TYR B 2 33  ? 8.637   10.850 88.928  1.00 37.16 ? 38  TYR L CD2 1 
ATOM   1911 C  CE1 . TYR B 2 33  ? 11.080  10.432 87.690  1.00 42.14 ? 38  TYR L CE1 1 
ATOM   1912 C  CE2 . TYR B 2 33  ? 8.695   10.092 87.769  1.00 36.37 ? 38  TYR L CE2 1 
ATOM   1913 C  CZ  . TYR B 2 33  ? 9.918   9.899  87.147  1.00 40.44 ? 38  TYR L CZ  1 
ATOM   1914 O  OH  . TYR B 2 33  ? 10.002  9.149  85.996  1.00 46.32 ? 38  TYR L OH  1 
ATOM   1915 N  N   . LEU B 2 34  ? 12.217  13.507 93.129  1.00 18.78 ? 39  LEU L N   1 
ATOM   1916 C  CA  . LEU B 2 34  ? 12.505  14.508 94.157  1.00 17.48 ? 39  LEU L CA  1 
ATOM   1917 C  C   . LEU B 2 34  ? 13.780  15.235 93.734  1.00 16.78 ? 39  LEU L C   1 
ATOM   1918 O  O   . LEU B 2 34  ? 14.776  14.585 93.403  1.00 19.20 ? 39  LEU L O   1 
ATOM   1919 C  CB  . LEU B 2 34  ? 12.662  13.777 95.498  1.00 18.04 ? 39  LEU L CB  1 
ATOM   1920 C  CG  . LEU B 2 34  ? 12.644  14.607 96.784  1.00 18.79 ? 39  LEU L CG  1 
ATOM   1921 C  CD1 . LEU B 2 34  ? 13.904  15.440 96.997  1.00 19.62 ? 39  LEU L CD1 1 
ATOM   1922 C  CD2 . LEU B 2 34  ? 11.395  15.436 96.915  1.00 18.90 ? 39  LEU L CD2 1 
ATOM   1923 N  N   . ALA B 2 35  ? 13.721  16.565 93.622  1.00 14.21 ? 40  ALA L N   1 
ATOM   1924 C  CA  . ALA B 2 35  ? 14.810  17.397 93.185  1.00 14.53 ? 40  ALA L CA  1 
ATOM   1925 C  C   . ALA B 2 35  ? 15.220  18.349 94.303  1.00 14.19 ? 40  ALA L C   1 
ATOM   1926 O  O   . ALA B 2 35  ? 14.405  18.668 95.177  1.00 14.92 ? 40  ALA L O   1 
ATOM   1927 C  CB  . ALA B 2 35  ? 14.426  18.249 91.974  1.00 14.23 ? 40  ALA L CB  1 
ATOM   1928 N  N   . TRP B 2 36  ? 16.465  18.803 94.210  1.00 14.85 ? 41  TRP L N   1 
ATOM   1929 C  CA  . TRP B 2 36  ? 17.000  19.855 95.071  1.00 15.10 ? 41  TRP L CA  1 
ATOM   1930 C  C   . TRP B 2 36  ? 17.581  20.931 94.204  1.00 14.77 ? 41  TRP L C   1 
ATOM   1931 O  O   . TRP B 2 36  ? 18.319  20.647 93.263  1.00 15.84 ? 41  TRP L O   1 
ATOM   1932 C  CB  . TRP B 2 36  ? 18.089  19.369 96.028  1.00 14.86 ? 41  TRP L CB  1 
ATOM   1933 C  CG  . TRP B 2 36  ? 17.629  18.374 97.050  1.00 15.33 ? 41  TRP L CG  1 
ATOM   1934 C  CD1 . TRP B 2 36  ? 17.542  17.017 96.973  1.00 15.90 ? 41  TRP L CD1 1 
ATOM   1935 C  CD2 . TRP B 2 36  ? 17.208  18.714 98.381  1.00 16.54 ? 41  TRP L CD2 1 
ATOM   1936 N  NE1 . TRP B 2 36  ? 17.078  16.498 98.136  1.00 16.63 ? 41  TRP L NE1 1 
ATOM   1937 C  CE2 . TRP B 2 36  ? 16.838  17.520 99.015  1.00 14.35 ? 41  TRP L CE2 1 
ATOM   1938 C  CE3 . TRP B 2 36  ? 17.077  19.922 99.072  1.00 16.00 ? 41  TRP L CE3 1 
ATOM   1939 C  CZ2 . TRP B 2 36  ? 16.411  17.480 100.346 1.00 15.43 ? 41  TRP L CZ2 1 
ATOM   1940 C  CZ3 . TRP B 2 36  ? 16.690  19.871 100.383 1.00 16.61 ? 41  TRP L CZ3 1 
ATOM   1941 C  CH2 . TRP B 2 36  ? 16.382  18.668 101.020 1.00 17.04 ? 41  TRP L CH2 1 
ATOM   1942 N  N   . TYR B 2 37  ? 17.327  22.175 94.595  1.00 14.92 ? 42  TYR L N   1 
ATOM   1943 C  CA  . TYR B 2 37  ? 17.860  23.368 93.954  1.00 14.56 ? 42  TYR L CA  1 
ATOM   1944 C  C   . TYR B 2 37  ? 18.639  24.230 94.929  1.00 15.64 ? 42  TYR L C   1 
ATOM   1945 O  O   . TYR B 2 37  ? 18.266  24.319 96.117  1.00 15.40 ? 42  TYR L O   1 
ATOM   1946 C  CB  . TYR B 2 37  ? 16.712  24.235 93.420  1.00 14.13 ? 42  TYR L CB  1 
ATOM   1947 C  CG  . TYR B 2 37  ? 15.804  23.556 92.438  1.00 14.55 ? 42  TYR L CG  1 
ATOM   1948 C  CD1 . TYR B 2 37  ? 14.714  22.830 92.865  1.00 15.53 ? 42  TYR L CD1 1 
ATOM   1949 C  CD2 . TYR B 2 37  ? 16.037  23.643 91.082  1.00 16.64 ? 42  TYR L CD2 1 
ATOM   1950 C  CE1 . TYR B 2 37  ? 13.907  22.140 91.996  1.00 17.56 ? 42  TYR L CE1 1 
ATOM   1951 C  CE2 . TYR B 2 37  ? 15.207  22.962 90.183  1.00 16.73 ? 42  TYR L CE2 1 
ATOM   1952 C  CZ  . TYR B 2 37  ? 14.134  22.254 90.649  1.00 18.12 ? 42  TYR L CZ  1 
ATOM   1953 O  OH  . TYR B 2 37  ? 13.255  21.559 89.800  1.00 19.99 ? 42  TYR L OH  1 
ATOM   1954 N  N   . GLN B 2 38  ? 19.654  24.902 94.404  1.00 14.43 ? 43  GLN L N   1 
ATOM   1955 C  CA  . GLN B 2 38  ? 20.397  25.955 95.088  1.00 14.18 ? 43  GLN L CA  1 
ATOM   1956 C  C   . GLN B 2 38  ? 19.976  27.312 94.542  1.00 16.51 ? 43  GLN L C   1 
ATOM   1957 O  O   . GLN B 2 38  ? 20.027  27.522 93.329  1.00 15.53 ? 43  GLN L O   1 
ATOM   1958 C  CB  . GLN B 2 38  ? 21.893  25.784 94.854  1.00 14.16 ? 43  GLN L CB  1 
ATOM   1959 C  CG  . GLN B 2 38  ? 22.754  26.774 95.633  1.00 12.92 ? 43  GLN L CG  1 
ATOM   1960 C  CD  . GLN B 2 38  ? 24.169  26.765 95.137  1.00 15.68 ? 43  GLN L CD  1 
ATOM   1961 O  OE1 . GLN B 2 38  ? 24.442  27.301 94.062  1.00 17.45 ? 43  GLN L OE1 1 
ATOM   1962 N  NE2 . GLN B 2 38  ? 25.099  26.272 95.934  1.00 15.10 ? 43  GLN L NE2 1 
ATOM   1963 N  N   . GLN B 2 39  ? 19.531  28.213 95.420  1.00 13.91 ? 44  GLN L N   1 
ATOM   1964 C  CA  . GLN B 2 39  ? 19.276  29.575 95.002  1.00 16.34 ? 44  GLN L CA  1 
ATOM   1965 C  C   . GLN B 2 39  ? 20.082  30.571 95.817  1.00 17.76 ? 44  GLN L C   1 
ATOM   1966 O  O   . GLN B 2 39  ? 19.918  30.674 97.031  1.00 17.60 ? 44  GLN L O   1 
ATOM   1967 C  CB  . GLN B 2 39  ? 17.815  29.950 95.107  1.00 17.23 ? 44  GLN L CB  1 
ATOM   1968 C  CG  . GLN B 2 39  ? 17.525  31.291 94.434  1.00 17.39 ? 44  GLN L CG  1 
ATOM   1969 C  CD  . GLN B 2 39  ? 16.076  31.699 94.526  1.00 17.70 ? 44  GLN L CD  1 
ATOM   1970 O  OE1 . GLN B 2 39  ? 15.390  31.411 95.497  1.00 17.28 ? 44  GLN L OE1 1 
ATOM   1971 N  NE2 . GLN B 2 39  ? 15.632  32.465 93.527  1.00 17.32 ? 44  GLN L NE2 1 
ATOM   1972 N  N   . LYS B 2 40  ? 20.875  31.369 95.102  1.00 17.68 ? 45  LYS L N   1 
ATOM   1973 C  CA  . LYS B 2 40  ? 21.585  32.501 95.674  1.00 19.84 ? 45  LYS L CA  1 
ATOM   1974 C  C   . LYS B 2 40  ? 20.749  33.761 95.558  1.00 22.20 ? 45  LYS L C   1 
ATOM   1975 O  O   . LYS B 2 40  ? 19.885  33.861 94.701  1.00 19.93 ? 45  LYS L O   1 
ATOM   1976 C  CB  . LYS B 2 40  ? 22.828  32.803 94.840  1.00 22.72 ? 45  LYS L CB  1 
ATOM   1977 C  CG  . LYS B 2 40  ? 23.784  31.651 94.613  1.00 28.66 ? 45  LYS L CG  1 
ATOM   1978 C  CD  . LYS B 2 40  ? 24.724  31.613 95.688  1.00 26.24 ? 45  LYS L CD  1 
ATOM   1979 C  CE  . LYS B 2 40  ? 25.838  30.584 95.612  1.00 20.87 ? 45  LYS L CE  1 
ATOM   1980 N  NZ  . LYS B 2 40  ? 26.737  30.863 96.775  1.00 19.93 ? 45  LYS L NZ  1 
ATOM   1981 N  N   . PRO B 2 41  ? 21.008  34.800 96.391  1.00 25.31 ? 46  PRO L N   1 
ATOM   1982 C  CA  . PRO B 2 41  ? 20.056  35.902 96.506  1.00 28.01 ? 46  PRO L CA  1 
ATOM   1983 C  C   . PRO B 2 41  ? 19.907  36.619 95.187  1.00 24.80 ? 46  PRO L C   1 
ATOM   1984 O  O   . PRO B 2 41  ? 20.909  36.935 94.559  1.00 28.53 ? 46  PRO L O   1 
ATOM   1985 C  CB  . PRO B 2 41  ? 20.692  36.837 97.535  1.00 27.43 ? 46  PRO L CB  1 
ATOM   1986 C  CG  . PRO B 2 41  ? 21.593  35.930 98.325  1.00 30.11 ? 46  PRO L CG  1 
ATOM   1987 C  CD  . PRO B 2 41  ? 22.141  34.938 97.322  1.00 29.23 ? 46  PRO L CD  1 
ATOM   1988 N  N   . GLY B 2 42  ? 18.654  36.775 94.750  1.00 27.74 ? 47  GLY L N   1 
ATOM   1989 C  CA  . GLY B 2 42  ? 18.386  37.522 93.534  1.00 26.67 ? 47  GLY L CA  1 
ATOM   1990 C  C   . GLY B 2 42  ? 18.833  36.848 92.221  1.00 27.53 ? 47  GLY L C   1 
ATOM   1991 O  O   . GLY B 2 42  ? 19.013  37.512 91.205  1.00 25.43 ? 47  GLY L O   1 
ATOM   1992 N  N   . GLN B 2 43  ? 19.049  35.537 92.238  1.00 21.44 ? 48  GLN L N   1 
ATOM   1993 C  CA  . GLN B 2 43  ? 19.568  34.787 91.094  1.00 20.36 ? 48  GLN L CA  1 
ATOM   1994 C  C   . GLN B 2 43  ? 18.635  33.620 90.813  1.00 19.46 ? 48  GLN L C   1 
ATOM   1995 O  O   . GLN B 2 43  ? 17.886  33.194 91.676  1.00 19.08 ? 48  GLN L O   1 
ATOM   1996 C  CB  . GLN B 2 43  ? 20.972  34.234 91.364  1.00 25.28 ? 48  GLN L CB  1 
ATOM   1997 C  CG  . GLN B 2 43  ? 21.991  35.342 91.606  1.00 34.65 ? 48  GLN L CG  1 
ATOM   1998 C  CD  . GLN B 2 43  ? 22.515  35.944 90.323  1.00 54.23 ? 48  GLN L CD  1 
ATOM   1999 O  OE1 . GLN B 2 43  ? 22.550  35.306 89.265  1.00 65.40 ? 48  GLN L OE1 1 
ATOM   2000 N  NE2 . GLN B 2 43  ? 22.985  37.178 90.421  1.00 66.61 ? 48  GLN L NE2 1 
ATOM   2001 N  N   . THR B 2 44  ? 18.684  33.090 89.571  1.00 19.11 ? 49  THR L N   1 
ATOM   2002 C  CA  . THR B 2 44  ? 17.882  31.959 89.198  1.00 17.50 ? 49  THR L CA  1 
ATOM   2003 C  C   . THR B 2 44  ? 18.331  30.740 90.005  1.00 15.76 ? 49  THR L C   1 
ATOM   2004 O  O   . THR B 2 44  ? 19.536  30.467 90.043  1.00 18.43 ? 49  THR L O   1 
ATOM   2005 C  CB  . THR B 2 44  ? 18.086  31.613 87.707  1.00 21.99 ? 49  THR L CB  1 
ATOM   2006 O  OG1 . THR B 2 44  ? 17.816  32.808 86.969  1.00 27.48 ? 49  THR L OG1 1 
ATOM   2007 C  CG2 . THR B 2 44  ? 17.215  30.479 87.231  1.00 26.31 ? 49  THR L CG2 1 
ATOM   2008 N  N   . PRO B 2 45  ? 17.391  29.946 90.499  1.00 15.58 ? 50  PRO L N   1 
ATOM   2009 C  CA  . PRO B 2 45  ? 17.720  28.644 91.081  1.00 15.87 ? 50  PRO L CA  1 
ATOM   2010 C  C   . PRO B 2 45  ? 18.455  27.750 90.067  1.00 15.56 ? 50  PRO L C   1 
ATOM   2011 O  O   . PRO B 2 45  ? 18.178  27.767 88.853  1.00 17.87 ? 50  PRO L O   1 
ATOM   2012 C  CB  . PRO B 2 45  ? 16.361  28.058 91.449  1.00 16.77 ? 50  PRO L CB  1 
ATOM   2013 C  CG  . PRO B 2 45  ? 15.477  29.264 91.691  1.00 16.67 ? 50  PRO L CG  1 
ATOM   2014 C  CD  . PRO B 2 45  ? 15.943  30.220 90.619  1.00 17.41 ? 50  PRO L CD  1 
ATOM   2015 N  N   . ARG B 2 46  ? 19.440  26.986 90.576  1.00 15.56 ? 51  ARG L N   1 
ATOM   2016 C  CA  . ARG B 2 46  ? 20.136  25.961 89.827  1.00 16.75 ? 51  ARG L CA  1 
ATOM   2017 C  C   . ARG B 2 46  ? 19.704  24.595 90.337  1.00 16.46 ? 51  ARG L C   1 
ATOM   2018 O  O   . ARG B 2 46  ? 19.623  24.348 91.561  1.00 15.01 ? 51  ARG L O   1 
ATOM   2019 C  CB  . ARG B 2 46  ? 21.655  26.085 89.937  1.00 17.93 ? 51  ARG L CB  1 
ATOM   2020 C  CG  . ARG B 2 46  ? 22.210  27.347 89.294  1.00 22.94 ? 51  ARG L CG  1 
ATOM   2021 C  CD  . ARG B 2 46  ? 23.715  27.335 89.561  1.00 30.40 ? 51  ARG L CD  1 
ATOM   2022 N  NE  . ARG B 2 46  ? 24.333  26.271 88.760  1.00 31.49 ? 51  ARG L NE  1 
ATOM   2023 C  CZ  . ARG B 2 46  ? 25.503  25.671 89.008  1.00 32.12 ? 51  ARG L CZ  1 
ATOM   2024 N  NH1 . ARG B 2 46  ? 26.159  25.858 90.146  1.00 29.13 ? 51  ARG L NH1 1 
ATOM   2025 N  NH2 . ARG B 2 46  ? 25.993  24.830 88.122  1.00 32.79 ? 51  ARG L NH2 1 
ATOM   2026 N  N   . LEU B 2 47  ? 19.420  23.695 89.393  1.00 14.84 ? 52  LEU L N   1 
ATOM   2027 C  CA  . LEU B 2 47  ? 19.154  22.319 89.751  1.00 15.16 ? 52  LEU L CA  1 
ATOM   2028 C  C   . LEU B 2 47  ? 20.448  21.640 90.189  1.00 16.73 ? 52  LEU L C   1 
ATOM   2029 O  O   . LEU B 2 47  ? 21.482  21.683 89.460  1.00 16.17 ? 52  LEU L O   1 
ATOM   2030 C  CB  . LEU B 2 47  ? 18.563  21.587 88.553  1.00 15.88 ? 52  LEU L CB  1 
ATOM   2031 C  CG  . LEU B 2 47  ? 18.304  20.111 88.763  1.00 17.13 ? 52  LEU L CG  1 
ATOM   2032 C  CD1 . LEU B 2 47  ? 17.161  19.879 89.724  1.00 16.64 ? 52  LEU L CD1 1 
ATOM   2033 C  CD2 . LEU B 2 47  ? 18.002  19.422 87.413  1.00 18.87 ? 52  LEU L CD2 1 
ATOM   2034 N  N   . PHE B 2 48  ? 20.417  21.043 91.393  1.00 14.67 ? 53  PHE L N   1 
ATOM   2035 C  CA  . PHE B 2 48  ? 21.574  20.355 91.946  1.00 14.99 ? 53  PHE L CA  1 
ATOM   2036 C  C   . PHE B 2 48  ? 21.437  18.842 91.925  1.00 14.84 ? 53  PHE L C   1 
ATOM   2037 O  O   . PHE B 2 48  ? 22.414  18.179 91.577  1.00 16.79 ? 53  PHE L O   1 
ATOM   2038 C  CB  . PHE B 2 48  ? 21.953  20.896 93.333  1.00 15.34 ? 53  PHE L CB  1 
ATOM   2039 C  CG  . PHE B 2 48  ? 23.006  21.982 93.331  1.00 13.47 ? 53  PHE L CG  1 
ATOM   2040 C  CD1 . PHE B 2 48  ? 22.840  23.120 92.549  1.00 16.49 ? 53  PHE L CD1 1 
ATOM   2041 C  CD2 . PHE B 2 48  ? 24.139  21.930 94.139  1.00 14.93 ? 53  PHE L CD2 1 
ATOM   2042 C  CE1 . PHE B 2 48  ? 23.780  24.127 92.527  1.00 16.53 ? 53  PHE L CE1 1 
ATOM   2043 C  CE2 . PHE B 2 48  ? 25.074  22.962 94.104  1.00 14.76 ? 53  PHE L CE2 1 
ATOM   2044 C  CZ  . PHE B 2 48  ? 24.899  24.042 93.285  1.00 16.67 ? 53  PHE L CZ  1 
ATOM   2045 N  N   . ILE B 2 49  ? 20.328  18.336 92.416  1.00 14.12 ? 54  ILE L N   1 
ATOM   2046 C  CA  . ILE B 2 49  ? 20.011  16.924 92.531  1.00 16.51 ? 54  ILE L CA  1 
ATOM   2047 C  C   . ILE B 2 49  ? 18.687  16.667 91.824  1.00 16.49 ? 54  ILE L C   1 
ATOM   2048 O  O   . ILE B 2 49  ? 17.728  17.390 92.034  1.00 17.03 ? 54  ILE L O   1 
ATOM   2049 C  CB  . ILE B 2 49  ? 19.993  16.474 94.013  1.00 17.80 ? 54  ILE L CB  1 
ATOM   2050 C  CG1 . ILE B 2 49  ? 21.323  16.678 94.754  1.00 18.32 ? 54  ILE L CG1 1 
ATOM   2051 C  CG2 . ILE B 2 49  ? 19.493  15.050 94.122  1.00 17.38 ? 54  ILE L CG2 1 
ATOM   2052 C  CD1 . ILE B 2 49  ? 22.534  15.899 94.259  1.00 19.95 ? 54  ILE L CD1 1 
ATOM   2053 N  N   . TYR B 2 50  ? 18.574  15.546 91.068  1.00 15.41 ? 55  TYR L N   1 
ATOM   2054 C  CA  . TYR B 2 50  ? 17.308  15.107 90.507  1.00 16.02 ? 55  TYR L CA  1 
ATOM   2055 C  C   . TYR B 2 50  ? 17.214  13.600 90.774  1.00 15.87 ? 55  TYR L C   1 
ATOM   2056 O  O   . TYR B 2 50  ? 18.216  12.916 91.008  1.00 18.06 ? 55  TYR L O   1 
ATOM   2057 C  CB  . TYR B 2 50  ? 17.158  15.480 89.027  1.00 17.04 ? 55  TYR L CB  1 
ATOM   2058 C  CG  . TYR B 2 50  ? 18.136  14.790 88.108  1.00 18.30 ? 55  TYR L CG  1 
ATOM   2059 C  CD1 . TYR B 2 50  ? 19.458  15.209 88.040  1.00 18.49 ? 55  TYR L CD1 1 
ATOM   2060 C  CD2 . TYR B 2 50  ? 17.742  13.698 87.365  1.00 22.46 ? 55  TYR L CD2 1 
ATOM   2061 C  CE1 . TYR B 2 50  ? 20.380  14.558 87.226  1.00 18.73 ? 55  TYR L CE1 1 
ATOM   2062 C  CE2 . TYR B 2 50  ? 18.653  13.034 86.561  1.00 21.64 ? 55  TYR L CE2 1 
ATOM   2063 C  CZ  . TYR B 2 50  ? 19.952  13.477 86.480  1.00 21.88 ? 55  TYR L CZ  1 
ATOM   2064 O  OH  . TYR B 2 50  ? 20.884  12.829 85.677  1.00 26.21 ? 55  TYR L OH  1 
ATOM   2065 N  N   . GLY B 2 51  ? 15.992  13.088 90.739  1.00 17.28 ? 56  GLY L N   1 
ATOM   2066 C  CA  . GLY B 2 51  ? 15.745  11.675 90.972  1.00 20.67 ? 56  GLY L CA  1 
ATOM   2067 C  C   . GLY B 2 51  ? 16.310  11.213 92.315  1.00 19.85 ? 56  GLY L C   1 
ATOM   2068 O  O   . GLY B 2 51  ? 16.888  10.129 92.392  1.00 19.42 ? 56  GLY L O   1 
ATOM   2069 N  N   . ALA B 2 52  ? 16.224  12.108 93.319  1.00 20.22 ? 57  ALA L N   1 
ATOM   2070 C  CA  . ALA B 2 52  ? 16.644  11.938 94.708  1.00 18.31 ? 57  ALA L CA  1 
ATOM   2071 C  C   . ALA B 2 52  ? 18.164  11.922 94.905  1.00 19.19 ? 57  ALA L C   1 
ATOM   2072 O  O   . ALA B 2 52  ? 18.623  12.443 95.915  1.00 18.51 ? 57  ALA L O   1 
ATOM   2073 C  CB  . ALA B 2 52  ? 16.004  10.745 95.334  1.00 16.98 ? 57  ALA L CB  1 
ATOM   2074 N  N   . SER B 2 53  ? 18.934  11.295 93.991  1.00 18.44 ? 65  SER L N   1 
ATOM   2075 C  CA  . SER B 2 53  ? 20.351  11.065 94.260  1.00 18.70 ? 65  SER L CA  1 
ATOM   2076 C  C   . SER B 2 53  ? 21.256  11.372 93.077  1.00 18.96 ? 65  SER L C   1 
ATOM   2077 O  O   . SER B 2 53  ? 22.473  11.205 93.232  1.00 22.41 ? 65  SER L O   1 
ATOM   2078 C  CB  . SER B 2 53  ? 20.586  9.647  94.701  1.00 19.31 ? 65  SER L CB  1 
ATOM   2079 O  OG  . SER B 2 53  ? 20.172  8.743  93.690  1.00 21.41 ? 65  SER L OG  1 
ATOM   2080 N  N   . ASN B 2 54  ? 20.724  11.863 91.924  1.00 18.63 ? 66  ASN L N   1 
ATOM   2081 C  CA  . ASN B 2 54  ? 21.563  12.133 90.762  1.00 17.79 ? 66  ASN L CA  1 
ATOM   2082 C  C   . ASN B 2 54  ? 22.082  13.560 90.764  1.00 18.64 ? 66  ASN L C   1 
ATOM   2083 O  O   . ASN B 2 54  ? 21.299  14.493 90.953  1.00 19.01 ? 66  ASN L O   1 
ATOM   2084 C  CB  . ASN B 2 54  ? 20.758  11.931 89.473  1.00 20.83 ? 66  ASN L CB  1 
ATOM   2085 C  CG  . ASN B 2 54  ? 20.260  10.511 89.355  1.00 23.33 ? 66  ASN L CG  1 
ATOM   2086 O  OD1 . ASN B 2 54  ? 21.043  9.633  89.007  1.00 27.82 ? 66  ASN L OD1 1 
ATOM   2087 N  ND2 . ASN B 2 54  ? 19.009  10.256 89.667  1.00 32.39 ? 66  ASN L ND2 1 
ATOM   2088 N  N   . ARG B 2 55  ? 23.386  13.760 90.547  1.00 18.53 ? 67  ARG L N   1 
ATOM   2089 C  CA  . ARG B 2 55  ? 23.929  15.096 90.430  1.00 17.29 ? 67  ARG L CA  1 
ATOM   2090 C  C   . ARG B 2 55  ? 23.595  15.637 89.047  1.00 18.94 ? 67  ARG L C   1 
ATOM   2091 O  O   . ARG B 2 55  ? 23.820  14.952 88.025  1.00 19.08 ? 67  ARG L O   1 
ATOM   2092 C  CB  . ARG B 2 55  ? 25.439  15.142 90.647  1.00 18.33 ? 67  ARG L CB  1 
ATOM   2093 C  CG  . ARG B 2 55  ? 25.896  14.726 92.038  1.00 18.16 ? 67  ARG L CG  1 
ATOM   2094 C  CD  . ARG B 2 55  ? 27.365  15.075 92.177  1.00 18.45 ? 67  ARG L CD  1 
ATOM   2095 N  NE  . ARG B 2 55  ? 27.910  14.532 93.404  1.00 21.88 ? 67  ARG L NE  1 
ATOM   2096 C  CZ  . ARG B 2 55  ? 28.277  13.272 93.587  1.00 23.57 ? 67  ARG L CZ  1 
ATOM   2097 N  NH1 . ARG B 2 55  ? 28.326  12.438 92.571  1.00 26.03 ? 67  ARG L NH1 1 
ATOM   2098 N  NH2 . ARG B 2 55  ? 28.702  12.870 94.769  1.00 24.83 ? 67  ARG L NH2 1 
ATOM   2099 N  N   . ALA B 2 56  ? 23.168  16.913 89.008  1.00 17.65 ? 68  ALA L N   1 
ATOM   2100 C  CA  . ALA B 2 56  ? 22.993  17.611 87.751  1.00 17.85 ? 68  ALA L CA  1 
ATOM   2101 C  C   . ALA B 2 56  ? 24.343  17.940 87.120  1.00 18.03 ? 68  ALA L C   1 
ATOM   2102 O  O   . ALA B 2 56  ? 25.400  17.820 87.750  1.00 17.31 ? 68  ALA L O   1 
ATOM   2103 C  CB  . ALA B 2 56  ? 22.109  18.847 87.921  1.00 18.16 ? 68  ALA L CB  1 
ATOM   2104 N  N   . THR B 2 57  ? 24.328  18.395 85.865  1.00 19.11 ? 69  THR L N   1 
ATOM   2105 C  CA  . THR B 2 57  ? 25.553  18.842 85.213  1.00 18.07 ? 69  THR L CA  1 
ATOM   2106 C  C   . THR B 2 57  ? 26.250  19.954 85.977  1.00 18.64 ? 69  THR L C   1 
ATOM   2107 O  O   . THR B 2 57  ? 25.625  20.840 86.557  1.00 19.20 ? 69  THR L O   1 
ATOM   2108 C  CB  . THR B 2 57  ? 25.291  19.333 83.784  1.00 20.95 ? 69  THR L CB  1 
ATOM   2109 O  OG1 . THR B 2 57  ? 24.341  20.408 83.847  1.00 19.80 ? 69  THR L OG1 1 
ATOM   2110 C  CG2 . THR B 2 57  ? 24.874  18.172 82.926  1.00 22.12 ? 69  THR L CG2 1 
ATOM   2111 N  N   . GLY B 2 58  ? 27.560  19.802 86.111  1.00 17.85 ? 70  GLY L N   1 
ATOM   2112 C  CA  . GLY B 2 58  ? 28.412  20.845 86.693  1.00 20.22 ? 70  GLY L CA  1 
ATOM   2113 C  C   . GLY B 2 58  ? 28.377  20.915 88.221  1.00 21.55 ? 70  GLY L C   1 
ATOM   2114 O  O   . GLY B 2 58  ? 28.904  21.869 88.803  1.00 24.12 ? 70  GLY L O   1 
ATOM   2115 N  N   . ILE B 2 59  ? 27.794  19.921 88.865  1.00 18.19 ? 71  ILE L N   1 
ATOM   2116 C  CA  . ILE B 2 59  ? 27.638  19.909 90.322  1.00 18.50 ? 71  ILE L CA  1 
ATOM   2117 C  C   . ILE B 2 59  ? 28.780  19.104 90.924  1.00 18.43 ? 71  ILE L C   1 
ATOM   2118 O  O   . ILE B 2 59  ? 29.028  17.969 90.539  1.00 18.28 ? 71  ILE L O   1 
ATOM   2119 C  CB  . ILE B 2 59  ? 26.271  19.322 90.709  1.00 16.99 ? 71  ILE L CB  1 
ATOM   2120 C  CG1 . ILE B 2 59  ? 25.104  20.101 90.079  1.00 17.68 ? 71  ILE L CG1 1 
ATOM   2121 C  CG2 . ILE B 2 59  ? 26.139  19.136 92.218  1.00 18.20 ? 71  ILE L CG2 1 
ATOM   2122 C  CD1 . ILE B 2 59  ? 25.082  21.570 90.425  1.00 18.78 ? 71  ILE L CD1 1 
ATOM   2123 N  N   . PRO B 2 60  ? 29.533  19.690 91.879  1.00 16.47 ? 72  PRO L N   1 
ATOM   2124 C  CA  . PRO B 2 60  ? 30.690  18.997 92.435  1.00 18.22 ? 72  PRO L CA  1 
ATOM   2125 C  C   . PRO B 2 60  ? 30.313  17.812 93.318  1.00 15.29 ? 72  PRO L C   1 
ATOM   2126 O  O   . PRO B 2 60  ? 29.169  17.692 93.809  1.00 17.56 ? 72  PRO L O   1 
ATOM   2127 C  CB  . PRO B 2 60  ? 31.401  20.073 93.245  1.00 21.47 ? 72  PRO L CB  1 
ATOM   2128 C  CG  . PRO B 2 60  ? 30.617  21.321 93.146  1.00 24.58 ? 72  PRO L CG  1 
ATOM   2129 C  CD  . PRO B 2 60  ? 29.324  21.037 92.386  1.00 18.66 ? 72  PRO L CD  1 
ATOM   2130 N  N   . ASP B 2 61  ? 31.290  16.909 93.517  1.00 16.87 ? 74  ASP L N   1 
ATOM   2131 C  CA  . ASP B 2 61  ? 31.123  15.663 94.238  1.00 18.95 ? 74  ASP L CA  1 
ATOM   2132 C  C   . ASP B 2 61  ? 30.660  15.871 95.684  1.00 16.50 ? 74  ASP L C   1 
ATOM   2133 O  O   . ASP B 2 61  ? 29.990  15.005 96.269  1.00 17.52 ? 74  ASP L O   1 
ATOM   2134 C  CB  . ASP B 2 61  ? 32.432  14.879 94.244  1.00 20.67 ? 74  ASP L CB  1 
ATOM   2135 C  CG  . ASP B 2 61  ? 32.707  14.145 92.937  1.00 25.63 ? 74  ASP L CG  1 
ATOM   2136 O  OD1 . ASP B 2 61  ? 31.832  14.151 92.035  1.00 25.99 ? 74  ASP L OD1 1 
ATOM   2137 O  OD2 . ASP B 2 61  ? 33.772  13.489 92.890  1.00 33.27 ? 74  ASP L OD2 1 
ATOM   2138 N  N   . ARG B 2 62  ? 30.973  17.027 96.300  1.00 15.68 ? 75  ARG L N   1 
ATOM   2139 C  CA  . ARG B 2 62  ? 30.593  17.227 97.714  1.00 15.48 ? 75  ARG L CA  1 
ATOM   2140 C  C   . ARG B 2 62  ? 29.085  17.301 97.912  1.00 17.20 ? 75  ARG L C   1 
ATOM   2141 O  O   . ARG B 2 62  ? 28.608  17.206 99.065  1.00 16.05 ? 75  ARG L O   1 
ATOM   2142 C  CB  . ARG B 2 62  ? 31.316  18.441 98.314  1.00 15.35 ? 75  ARG L CB  1 
ATOM   2143 C  CG  . ARG B 2 62  ? 30.930  19.783 97.704  1.00 15.53 ? 75  ARG L CG  1 
ATOM   2144 C  CD  . ARG B 2 62  ? 31.718  20.950 98.330  1.00 16.41 ? 75  ARG L CD  1 
ATOM   2145 N  NE  . ARG B 2 62  ? 31.424  22.260 97.773  1.00 15.93 ? 75  ARG L NE  1 
ATOM   2146 C  CZ  . ARG B 2 62  ? 31.901  22.749 96.646  1.00 16.29 ? 75  ARG L CZ  1 
ATOM   2147 N  NH1 . ARG B 2 62  ? 31.551  23.958 96.236  1.00 17.79 ? 75  ARG L NH1 1 
ATOM   2148 N  NH2 . ARG B 2 62  ? 32.769  22.041 95.930  1.00 16.35 ? 75  ARG L NH2 1 
ATOM   2149 N  N   . PHE B 2 63  ? 28.338  17.564 96.856  1.00 15.60 ? 76  PHE L N   1 
ATOM   2150 C  CA  . PHE B 2 63  ? 26.888  17.557 96.933  1.00 14.87 ? 76  PHE L CA  1 
ATOM   2151 C  C   . PHE B 2 63  ? 26.328  16.184 96.622  1.00 17.54 ? 76  PHE L C   1 
ATOM   2152 O  O   . PHE B 2 63  ? 26.654  15.575 95.593  1.00 17.47 ? 76  PHE L O   1 
ATOM   2153 C  CB  . PHE B 2 63  ? 26.248  18.546 95.948  1.00 14.79 ? 76  PHE L CB  1 
ATOM   2154 C  CG  . PHE B 2 63  ? 26.594  19.960 96.303  1.00 14.90 ? 76  PHE L CG  1 
ATOM   2155 C  CD1 . PHE B 2 63  ? 27.749  20.549 95.824  1.00 15.75 ? 76  PHE L CD1 1 
ATOM   2156 C  CD2 . PHE B 2 63  ? 25.735  20.740 97.085  1.00 15.32 ? 76  PHE L CD2 1 
ATOM   2157 C  CE1 . PHE B 2 63  ? 28.074  21.844 96.183  1.00 16.63 ? 76  PHE L CE1 1 
ATOM   2158 C  CE2 . PHE B 2 63  ? 26.073  22.044 97.434  1.00 15.99 ? 76  PHE L CE2 1 
ATOM   2159 C  CZ  . PHE B 2 63  ? 27.212  22.594 96.959  1.00 16.51 ? 76  PHE L CZ  1 
ATOM   2160 N  N   . SER B 2 64  ? 25.478  15.680 97.511  1.00 15.45 ? 77  SER L N   1 
ATOM   2161 C  CA  . SER B 2 64  ? 24.840  14.416 97.290  1.00 16.00 ? 77  SER L CA  1 
ATOM   2162 C  C   . SER B 2 64  ? 23.428  14.429 97.866  1.00 16.70 ? 77  SER L C   1 
ATOM   2163 O  O   . SER B 2 64  ? 23.042  15.291 98.665  1.00 16.05 ? 77  SER L O   1 
ATOM   2164 C  CB  . SER B 2 64  ? 25.643  13.233 97.808  1.00 19.61 ? 77  SER L CB  1 
ATOM   2165 O  OG  . SER B 2 64  ? 25.720  13.234 99.203  1.00 20.77 ? 77  SER L OG  1 
ATOM   2166 N  N   . GLY B 2 65  ? 22.583  13.577 97.266  1.00 17.09 ? 78  GLY L N   1 
ATOM   2167 C  CA  . GLY B 2 65  ? 21.218  13.411 97.751  1.00 18.63 ? 78  GLY L CA  1 
ATOM   2168 C  C   . GLY B 2 65  ? 20.890  11.960 98.064  1.00 18.10 ? 78  GLY L C   1 
ATOM   2169 O  O   . GLY B 2 65  ? 21.431  11.029 97.440  1.00 18.68 ? 78  GLY L O   1 
ATOM   2170 N  N   . SER B 2 66  ? 19.967  11.738 98.993  1.00 17.95 ? 79  SER L N   1 
ATOM   2171 C  CA  . SER B 2 66  ? 19.516  10.396 99.336  1.00 18.85 ? 79  SER L CA  1 
ATOM   2172 C  C   . SER B 2 66  ? 18.064  10.427 99.777  1.00 18.96 ? 79  SER L C   1 
ATOM   2173 O  O   . SER B 2 66  ? 17.502  11.491 100.082 1.00 18.55 ? 79  SER L O   1 
ATOM   2174 C  CB  . SER B 2 66  ? 20.402  9.757  100.386 1.00 20.24 ? 79  SER L CB  1 
ATOM   2175 O  OG  . SER B 2 66  ? 20.304  10.412 101.624 1.00 22.41 ? 79  SER L OG  1 
ATOM   2176 N  N   . GLY B 2 67  ? 17.455  9.230  99.903  1.00 18.95 ? 80  GLY L N   1 
ATOM   2177 C  CA  . GLY B 2 67  ? 16.098  9.153  100.434 1.00 17.84 ? 80  GLY L CA  1 
ATOM   2178 C  C   . GLY B 2 67  ? 15.118  8.418  99.529  1.00 20.70 ? 80  GLY L C   1 
ATOM   2179 O  O   . GLY B 2 67  ? 15.418  8.199  98.366  1.00 23.58 ? 80  GLY L O   1 
ATOM   2180 N  N   . SER B 2 68  ? 13.931  8.174  100.094 1.00 22.49 ? 83  SER L N   1 
ATOM   2181 C  CA  . SER B 2 68  ? 12.799  7.601  99.387  1.00 24.70 ? 83  SER L CA  1 
ATOM   2182 C  C   . SER B 2 68  ? 11.572  7.770  100.269 1.00 23.79 ? 83  SER L C   1 
ATOM   2183 O  O   . SER B 2 68  ? 11.685  8.094  101.454 1.00 22.20 ? 83  SER L O   1 
ATOM   2184 C  CB  . SER B 2 68  ? 13.011  6.145  99.055  1.00 28.13 ? 83  SER L CB  1 
ATOM   2185 O  OG  . SER B 2 68  ? 13.122  5.406  100.262 1.00 30.39 ? 83  SER L OG  1 
ATOM   2186 N  N   . GLY B 2 69  ? 10.391  7.549  99.679  1.00 23.29 ? 84  GLY L N   1 
ATOM   2187 C  CA  . GLY B 2 69  ? 9.146   7.572  100.429 1.00 24.26 ? 84  GLY L CA  1 
ATOM   2188 C  C   . GLY B 2 69  ? 8.792   8.980  100.862 1.00 22.16 ? 84  GLY L C   1 
ATOM   2189 O  O   . GLY B 2 69  ? 8.442   9.826  100.022 1.00 23.65 ? 84  GLY L O   1 
ATOM   2190 N  N   . THR B 2 70  ? 8.994   9.244  102.160 1.00 20.75 ? 85  THR L N   1 
ATOM   2191 C  CA  . THR B 2 70  ? 8.568   10.473 102.790 1.00 20.40 ? 85  THR L CA  1 
ATOM   2192 C  C   . THR B 2 70  ? 9.756   11.243 103.380 1.00 19.83 ? 85  THR L C   1 
ATOM   2193 O  O   . THR B 2 70  ? 9.498   12.232 104.048 1.00 20.97 ? 85  THR L O   1 
ATOM   2194 C  CB  . THR B 2 70  ? 7.495   10.247 103.853 1.00 22.21 ? 85  THR L CB  1 
ATOM   2195 O  OG1 . THR B 2 70  ? 7.912   9.312  104.851 1.00 23.63 ? 85  THR L OG1 1 
ATOM   2196 C  CG2 . THR B 2 70  ? 6.216   9.737  103.235 1.00 23.24 ? 85  THR L CG2 1 
ATOM   2197 N  N   . TYR B 2 71  ? 10.986  10.730 103.257 1.00 17.90 ? 86  TYR L N   1 
ATOM   2198 C  CA  . TYR B 2 71  ? 12.107  11.400 103.887 1.00 17.33 ? 86  TYR L CA  1 
ATOM   2199 C  C   . TYR B 2 71  ? 13.304  11.416 102.934 1.00 15.89 ? 86  TYR L C   1 
ATOM   2200 O  O   . TYR B 2 71  ? 13.775  10.388 102.459 1.00 16.97 ? 86  TYR L O   1 
ATOM   2201 C  CB  . TYR B 2 71  ? 12.512  10.749 105.211 1.00 18.47 ? 86  TYR L CB  1 
ATOM   2202 C  CG  . TYR B 2 71  ? 13.643  11.455 105.899 1.00 17.50 ? 86  TYR L CG  1 
ATOM   2203 C  CD1 . TYR B 2 71  ? 13.413  12.632 106.588 1.00 18.97 ? 86  TYR L CD1 1 
ATOM   2204 C  CD2 . TYR B 2 71  ? 14.947  10.959 105.840 1.00 18.80 ? 86  TYR L CD2 1 
ATOM   2205 C  CE1 . TYR B 2 71  ? 14.463  13.334 107.183 1.00 18.19 ? 86  TYR L CE1 1 
ATOM   2206 C  CE2 . TYR B 2 71  ? 16.000  11.632 106.458 1.00 18.50 ? 86  TYR L CE2 1 
ATOM   2207 C  CZ  . TYR B 2 71  ? 15.759  12.835 107.082 1.00 17.48 ? 86  TYR L CZ  1 
ATOM   2208 O  OH  . TYR B 2 71  ? 16.816  13.565 107.696 1.00 20.37 ? 86  TYR L OH  1 
ATOM   2209 N  N   . PHE B 2 72  ? 13.789  12.626 102.673 1.00 15.85 ? 87  PHE L N   1 
ATOM   2210 C  CA  . PHE B 2 72  ? 14.898  12.879 101.775 1.00 15.46 ? 87  PHE L CA  1 
ATOM   2211 C  C   . PHE B 2 72  ? 15.878  13.881 102.389 1.00 15.77 ? 87  PHE L C   1 
ATOM   2212 O  O   . PHE B 2 72  ? 15.480  14.787 103.132 1.00 15.87 ? 87  PHE L O   1 
ATOM   2213 C  CB  . PHE B 2 72  ? 14.381  13.485 100.453 1.00 17.23 ? 87  PHE L CB  1 
ATOM   2214 C  CG  . PHE B 2 72  ? 13.402  12.599 99.722  1.00 15.83 ? 87  PHE L CG  1 
ATOM   2215 C  CD1 . PHE B 2 72  ? 12.062  12.581 100.054 1.00 16.31 ? 87  PHE L CD1 1 
ATOM   2216 C  CD2 . PHE B 2 72  ? 13.861  11.747 98.741  1.00 17.10 ? 87  PHE L CD2 1 
ATOM   2217 C  CE1 . PHE B 2 72  ? 11.168  11.736 99.396  1.00 18.49 ? 87  PHE L CE1 1 
ATOM   2218 C  CE2 . PHE B 2 72  ? 12.978  10.897 98.066  1.00 17.47 ? 87  PHE L CE2 1 
ATOM   2219 C  CZ  . PHE B 2 72  ? 11.643  10.880 98.431  1.00 20.32 ? 87  PHE L CZ  1 
ATOM   2220 N  N   . THR B 2 73  ? 17.154  13.750 101.991 1.00 15.65 ? 88  THR L N   1 
ATOM   2221 C  CA  . THR B 2 73  ? 18.182  14.687 102.415 1.00 14.35 ? 88  THR L CA  1 
ATOM   2222 C  C   . THR B 2 73  ? 19.063  15.097 101.235 1.00 15.47 ? 88  THR L C   1 
ATOM   2223 O  O   . THR B 2 73  ? 19.306  14.311 100.310 1.00 16.87 ? 88  THR L O   1 
ATOM   2224 C  CB  . THR B 2 73  ? 19.045  14.146 103.581 1.00 16.35 ? 88  THR L CB  1 
ATOM   2225 O  OG1 . THR B 2 73  ? 19.680  12.964 103.105 1.00 18.46 ? 88  THR L OG1 1 
ATOM   2226 C  CG2 . THR B 2 73  ? 18.238  13.898 104.825 1.00 17.66 ? 88  THR L CG2 1 
ATOM   2227 N  N   . LEU B 2 74  ? 19.603  16.318 101.390 1.00 13.13 ? 89  LEU L N   1 
ATOM   2228 C  CA  . LEU B 2 74  ? 20.680  16.878 100.612 1.00 13.78 ? 89  LEU L CA  1 
ATOM   2229 C  C   . LEU B 2 74  ? 21.854  17.095 101.557 1.00 14.78 ? 89  LEU L C   1 
ATOM   2230 O  O   . LEU B 2 74  ? 21.661  17.748 102.594 1.00 15.72 ? 89  LEU L O   1 
ATOM   2231 C  CB  . LEU B 2 74  ? 20.248  18.213 100.021 1.00 14.85 ? 89  LEU L CB  1 
ATOM   2232 C  CG  . LEU B 2 74  ? 21.356  18.993 99.312  1.00 16.07 ? 89  LEU L CG  1 
ATOM   2233 C  CD1 . LEU B 2 74  ? 21.759  18.365 98.004  1.00 19.04 ? 89  LEU L CD1 1 
ATOM   2234 C  CD2 . LEU B 2 74  ? 20.932  20.448 99.073  1.00 16.79 ? 89  LEU L CD2 1 
ATOM   2235 N  N   . THR B 2 75  ? 22.995  16.486 101.213 1.00 14.72 ? 90  THR L N   1 
ATOM   2236 C  CA  . THR B 2 75  ? 24.219  16.609 101.954 1.00 15.74 ? 90  THR L CA  1 
ATOM   2237 C  C   . THR B 2 75  ? 25.250  17.446 101.215 1.00 15.81 ? 90  THR L C   1 
ATOM   2238 O  O   . THR B 2 75  ? 25.414  17.334 99.999  1.00 16.03 ? 90  THR L O   1 
ATOM   2239 C  CB  . THR B 2 75  ? 24.810  15.228 102.184 1.00 14.51 ? 90  THR L CB  1 
ATOM   2240 O  OG1 . THR B 2 75  ? 23.832  14.491 102.909 1.00 15.93 ? 90  THR L OG1 1 
ATOM   2241 C  CG2 . THR B 2 75  ? 26.106  15.291 102.948 1.00 17.05 ? 90  THR L CG2 1 
ATOM   2242 N  N   . ILE B 2 76  ? 25.917  18.344 101.948 1.00 14.14 ? 91  ILE L N   1 
ATOM   2243 C  CA  . ILE B 2 76  ? 27.167  18.928 101.477 1.00 14.18 ? 91  ILE L CA  1 
ATOM   2244 C  C   . ILE B 2 76  ? 28.255  18.346 102.390 1.00 14.77 ? 91  ILE L C   1 
ATOM   2245 O  O   . ILE B 2 76  ? 28.288  18.622 103.582 1.00 15.07 ? 91  ILE L O   1 
ATOM   2246 C  CB  . ILE B 2 76  ? 27.175  20.452 101.423 1.00 15.12 ? 91  ILE L CB  1 
ATOM   2247 C  CG1 . ILE B 2 76  ? 25.867  21.007 100.840 1.00 14.27 ? 91  ILE L CG1 1 
ATOM   2248 C  CG2 . ILE B 2 76  ? 28.411  20.909 100.690 1.00 15.54 ? 91  ILE L CG2 1 
ATOM   2249 C  CD1 . ILE B 2 76  ? 25.776  22.487 100.944 1.00 16.45 ? 91  ILE L CD1 1 
ATOM   2250 N  N   . SER B 2 77  ? 29.086  17.433 101.828 1.00 14.90 ? 92  SER L N   1 
ATOM   2251 C  CA  . SER B 2 77  ? 29.948  16.613 102.694 1.00 14.44 ? 92  SER L CA  1 
ATOM   2252 C  C   . SER B 2 77  ? 31.043  17.440 103.364 1.00 15.21 ? 92  SER L C   1 
ATOM   2253 O  O   . SER B 2 77  ? 31.424  17.134 104.493 1.00 16.73 ? 92  SER L O   1 
ATOM   2254 C  CB  . SER B 2 77  ? 30.603  15.478 101.902 1.00 16.35 ? 92  SER L CB  1 
ATOM   2255 O  OG  . SER B 2 77  ? 31.297  16.041 100.794 1.00 20.34 ? 92  SER L OG  1 
ATOM   2256 N  N   . ARG B 2 78  ? 31.528  18.485 102.692 1.00 15.43 ? 93  ARG L N   1 
ATOM   2257 C  CA  . ARG B 2 78  ? 32.633  19.317 103.146 1.00 17.03 ? 93  ARG L CA  1 
ATOM   2258 C  C   . ARG B 2 78  ? 32.384  20.714 102.595 1.00 15.32 ? 93  ARG L C   1 
ATOM   2259 O  O   . ARG B 2 78  ? 32.593  20.965 101.413 1.00 15.43 ? 93  ARG L O   1 
ATOM   2260 C  CB  . ARG B 2 78  ? 33.950  18.755 102.596 1.00 16.78 ? 93  ARG L CB  1 
ATOM   2261 C  CG  . ARG B 2 78  ? 35.203  19.468 103.053 1.00 19.55 ? 93  ARG L CG  1 
ATOM   2262 C  CD  . ARG B 2 78  ? 36.372  19.304 102.099 1.00 22.95 ? 93  ARG L CD  1 
ATOM   2263 N  NE  . ARG B 2 78  ? 36.125  20.131 100.911 1.00 25.36 ? 93  ARG L NE  1 
ATOM   2264 C  CZ  . ARG B 2 78  ? 35.778  19.682 99.716  1.00 27.95 ? 93  ARG L CZ  1 
ATOM   2265 N  NH1 . ARG B 2 78  ? 35.666  18.386 99.478  1.00 23.88 ? 93  ARG L NH1 1 
ATOM   2266 N  NH2 . ARG B 2 78  ? 35.658  20.539 98.714  1.00 29.75 ? 93  ARG L NH2 1 
ATOM   2267 N  N   . LEU B 2 79  ? 31.862  21.637 103.440 1.00 15.26 ? 94  LEU L N   1 
ATOM   2268 C  CA  . LEU B 2 79  ? 31.402  22.928 102.940 1.00 16.03 ? 94  LEU L CA  1 
ATOM   2269 C  C   . LEU B 2 79  ? 32.567  23.727 102.408 1.00 15.79 ? 94  LEU L C   1 
ATOM   2270 O  O   . LEU B 2 79  ? 33.660  23.741 102.984 1.00 17.02 ? 94  LEU L O   1 
ATOM   2271 C  CB  . LEU B 2 79  ? 30.724  23.709 104.070 1.00 17.37 ? 94  LEU L CB  1 
ATOM   2272 C  CG  . LEU B 2 79  ? 29.312  23.278 104.349 1.00 18.90 ? 94  LEU L CG  1 
ATOM   2273 C  CD1 . LEU B 2 79  ? 28.836  23.881 105.637 1.00 19.18 ? 94  LEU L CD1 1 
ATOM   2274 C  CD2 . LEU B 2 79  ? 28.366  23.677 103.192 1.00 18.69 ? 94  LEU L CD2 1 
ATOM   2275 N  N   . GLU B 2 80  ? 32.240  24.479 101.357 1.00 16.71 ? 95  GLU L N   1 
ATOM   2276 C  CA  . GLU B 2 80  ? 33.115  25.483 100.804 1.00 17.89 ? 95  GLU L CA  1 
ATOM   2277 C  C   . GLU B 2 80  ? 32.442  26.840 100.986 1.00 17.47 ? 95  GLU L C   1 
ATOM   2278 O  O   . GLU B 2 80  ? 31.217  26.955 101.060 1.00 16.27 ? 95  GLU L O   1 
ATOM   2279 C  CB  . GLU B 2 80  ? 33.416  25.227 99.337  1.00 17.42 ? 95  GLU L CB  1 
ATOM   2280 C  CG  . GLU B 2 80  ? 34.235  23.981 99.078  1.00 19.06 ? 95  GLU L CG  1 
ATOM   2281 C  CD  . GLU B 2 80  ? 35.695  24.120 99.461  1.00 25.54 ? 95  GLU L CD  1 
ATOM   2282 O  OE1 . GLU B 2 80  ? 36.161  25.251 99.676  1.00 26.31 ? 95  GLU L OE1 1 
ATOM   2283 O  OE2 . GLU B 2 80  ? 36.361  23.081 99.526  1.00 28.08 ? 95  GLU L OE2 1 
ATOM   2284 N  N   . PRO B 2 81  ? 33.224  27.947 101.031 1.00 17.67 ? 96  PRO L N   1 
ATOM   2285 C  CA  . PRO B 2 81  ? 32.602  29.249 101.293 1.00 18.33 ? 96  PRO L CA  1 
ATOM   2286 C  C   . PRO B 2 81  ? 31.591  29.694 100.231 1.00 16.56 ? 96  PRO L C   1 
ATOM   2287 O  O   . PRO B 2 81  ? 30.657  30.456 100.510 1.00 18.36 ? 96  PRO L O   1 
ATOM   2288 C  CB  . PRO B 2 81  ? 33.817  30.199 101.450 1.00 19.72 ? 96  PRO L CB  1 
ATOM   2289 C  CG  . PRO B 2 81  ? 35.020  29.451 101.011 1.00 23.54 ? 96  PRO L CG  1 
ATOM   2290 C  CD  . PRO B 2 81  ? 34.694  27.969 101.003 1.00 18.87 ? 96  PRO L CD  1 
ATOM   2291 N  N   . GLU B 2 82  ? 31.741  29.181 99.006  1.00 16.65 ? 97  GLU L N   1 
ATOM   2292 C  CA  . GLU B 2 82  ? 30.787  29.496 97.943  1.00 16.76 ? 97  GLU L CA  1 
ATOM   2293 C  C   . GLU B 2 82  ? 29.452  28.741 98.043  1.00 15.48 ? 97  GLU L C   1 
ATOM   2294 O  O   . GLU B 2 82  ? 28.581  28.914 97.178  1.00 17.82 ? 97  GLU L O   1 
ATOM   2295 C  CB  . GLU B 2 82  ? 31.413  29.309 96.553  1.00 18.22 ? 97  GLU L CB  1 
ATOM   2296 C  CG  . GLU B 2 82  ? 31.757  27.898 96.252  1.00 19.50 ? 97  GLU L CG  1 
ATOM   2297 C  CD  . GLU B 2 82  ? 33.215  27.543 96.513  1.00 26.46 ? 97  GLU L CD  1 
ATOM   2298 O  OE1 . GLU B 2 82  ? 33.707  26.683 95.745  1.00 27.15 ? 97  GLU L OE1 1 
ATOM   2299 O  OE2 . GLU B 2 82  ? 33.856  28.109 97.454  1.00 22.61 ? 97  GLU L OE2 1 
ATOM   2300 N  N   . ASP B 2 83  ? 29.226  27.927 99.084  1.00 14.71 ? 98  ASP L N   1 
ATOM   2301 C  CA  . ASP B 2 83  ? 28.043  27.088 99.189  1.00 14.34 ? 98  ASP L CA  1 
ATOM   2302 C  C   . ASP B 2 83  ? 26.866  27.708 99.952  1.00 14.65 ? 98  ASP L C   1 
ATOM   2303 O  O   . ASP B 2 83  ? 25.790  27.092 100.017 1.00 16.29 ? 98  ASP L O   1 
ATOM   2304 C  CB  . ASP B 2 83  ? 28.454  25.765 99.799  1.00 14.92 ? 98  ASP L CB  1 
ATOM   2305 C  CG  . ASP B 2 83  ? 29.404  24.951 98.934  1.00 16.55 ? 98  ASP L CG  1 
ATOM   2306 O  OD1 . ASP B 2 83  ? 29.519  25.184 97.728  1.00 16.36 ? 98  ASP L OD1 1 
ATOM   2307 O  OD2 . ASP B 2 83  ? 30.038  24.043 99.509  1.00 15.26 ? 98  ASP L OD2 1 
ATOM   2308 N  N   . PHE B 2 84  ? 26.975  28.968 100.412 1.00 14.73 ? 99  PHE L N   1 
ATOM   2309 C  CA  . PHE B 2 84  ? 25.797  29.608 101.012 1.00 14.03 ? 99  PHE L CA  1 
ATOM   2310 C  C   . PHE B 2 84  ? 24.712  29.759 99.955  1.00 14.68 ? 99  PHE L C   1 
ATOM   2311 O  O   . PHE B 2 84  ? 25.016  30.011 98.792  1.00 16.90 ? 99  PHE L O   1 
ATOM   2312 C  CB  . PHE B 2 84  ? 26.159  30.988 101.575 1.00 14.52 ? 99  PHE L CB  1 
ATOM   2313 C  CG  . PHE B 2 84  ? 26.449  32.064 100.561 1.00 17.59 ? 99  PHE L CG  1 
ATOM   2314 C  CD1 . PHE B 2 84  ? 25.408  32.820 100.029 1.00 17.58 ? 99  PHE L CD1 1 
ATOM   2315 C  CD2 . PHE B 2 84  ? 27.729  32.201 100.042 1.00 19.52 ? 99  PHE L CD2 1 
ATOM   2316 C  CE1 . PHE B 2 84  ? 25.672  33.770 99.043  1.00 18.41 ? 99  PHE L CE1 1 
ATOM   2317 C  CE2 . PHE B 2 84  ? 27.991  33.170 99.075  1.00 21.46 ? 99  PHE L CE2 1 
ATOM   2318 C  CZ  . PHE B 2 84  ? 26.959  33.940 98.589  1.00 19.97 ? 99  PHE L CZ  1 
ATOM   2319 N  N   . ALA B 2 85  ? 23.473  29.578 100.389 1.00 15.52 ? 100 ALA L N   1 
ATOM   2320 C  CA  . ALA B 2 85  ? 22.315  29.624 99.507  1.00 14.71 ? 100 ALA L CA  1 
ATOM   2321 C  C   . ALA B 2 85  ? 21.073  29.305 100.308 1.00 14.62 ? 100 ALA L C   1 
ATOM   2322 O  O   . ALA B 2 85  ? 21.159  28.844 101.450 1.00 15.02 ? 100 ALA L O   1 
ATOM   2323 C  CB  . ALA B 2 85  ? 22.399  28.627 98.368  1.00 14.68 ? 100 ALA L CB  1 
ATOM   2324 N  N   . VAL B 2 86  ? 19.913  29.456 99.678  1.00 14.62 ? 101 VAL L N   1 
ATOM   2325 C  CA  . VAL B 2 86  ? 18.711  28.765 100.107 1.00 14.88 ? 101 VAL L CA  1 
ATOM   2326 C  C   . VAL B 2 86  ? 18.577  27.516 99.247  1.00 16.11 ? 101 VAL L C   1 
ATOM   2327 O  O   . VAL B 2 86  ? 18.629  27.580 98.009  1.00 15.50 ? 101 VAL L O   1 
ATOM   2328 C  CB  . VAL B 2 86  ? 17.426  29.613 100.034 1.00 15.02 ? 101 VAL L CB  1 
ATOM   2329 C  CG1 . VAL B 2 86  ? 16.172  28.847 100.455 1.00 14.94 ? 101 VAL L CG1 1 
ATOM   2330 C  CG2 . VAL B 2 86  ? 17.564  30.877 100.855 1.00 16.79 ? 101 VAL L CG2 1 
ATOM   2331 N  N   . TYR B 2 87  ? 18.439  26.367 99.920  1.00 14.28 ? 102 TYR L N   1 
ATOM   2332 C  CA  . TYR B 2 87  ? 18.260  25.093 99.247  1.00 14.01 ? 102 TYR L CA  1 
ATOM   2333 C  C   . TYR B 2 87  ? 16.804  24.676 99.351  1.00 15.12 ? 102 TYR L C   1 
ATOM   2334 O  O   . TYR B 2 87  ? 16.241  24.653 100.459 1.00 14.77 ? 102 TYR L O   1 
ATOM   2335 C  CB  . TYR B 2 87  ? 19.190  24.033 99.845  1.00 16.32 ? 102 TYR L CB  1 
ATOM   2336 C  CG  . TYR B 2 87  ? 20.647  24.297 99.548  1.00 15.11 ? 102 TYR L CG  1 
ATOM   2337 C  CD1 . TYR B 2 87  ? 21.240  23.871 98.380  1.00 15.07 ? 102 TYR L CD1 1 
ATOM   2338 C  CD2 . TYR B 2 87  ? 21.413  25.030 100.420 1.00 15.52 ? 102 TYR L CD2 1 
ATOM   2339 C  CE1 . TYR B 2 87  ? 22.565  24.131 98.104  1.00 15.67 ? 102 TYR L CE1 1 
ATOM   2340 C  CE2 . TYR B 2 87  ? 22.721  25.335 100.131 1.00 15.08 ? 102 TYR L CE2 1 
ATOM   2341 C  CZ  . TYR B 2 87  ? 23.316  24.892 98.963  1.00 15.25 ? 102 TYR L CZ  1 
ATOM   2342 O  OH  . TYR B 2 87  ? 24.644  25.147 98.650  1.00 15.37 ? 102 TYR L OH  1 
ATOM   2343 N  N   . TYR B 2 88  ? 16.185  24.374 98.179  1.00 14.73 ? 103 TYR L N   1 
ATOM   2344 C  CA  . TYR B 2 88  ? 14.789  23.967 98.102  1.00 15.42 ? 103 TYR L CA  1 
ATOM   2345 C  C   . TYR B 2 88  ? 14.704  22.550 97.597  1.00 14.84 ? 103 TYR L C   1 
ATOM   2346 O  O   . TYR B 2 88  ? 15.454  22.185 96.682  1.00 16.17 ? 103 TYR L O   1 
ATOM   2347 C  CB  . TYR B 2 88  ? 14.015  24.839 97.111  1.00 14.99 ? 103 TYR L CB  1 
ATOM   2348 C  CG  . TYR B 2 88  ? 13.838  26.269 97.514  1.00 13.78 ? 103 TYR L CG  1 
ATOM   2349 C  CD1 . TYR B 2 88  ? 12.774  26.659 98.293  1.00 15.28 ? 103 TYR L CD1 1 
ATOM   2350 C  CD2 . TYR B 2 88  ? 14.761  27.251 97.136  1.00 13.87 ? 103 TYR L CD2 1 
ATOM   2351 C  CE1 . TYR B 2 88  ? 12.587  27.976 98.677  1.00 14.96 ? 103 TYR L CE1 1 
ATOM   2352 C  CE2 . TYR B 2 88  ? 14.567  28.577 97.477  1.00 15.23 ? 103 TYR L CE2 1 
ATOM   2353 C  CZ  . TYR B 2 88  ? 13.463  28.943 98.226  1.00 14.92 ? 103 TYR L CZ  1 
ATOM   2354 O  OH  . TYR B 2 88  ? 13.326  30.251 98.630  1.00 17.88 ? 103 TYR L OH  1 
ATOM   2355 N  N   . CYS B 2 89  ? 13.833  21.747 98.205  1.00 13.30 ? 104 CYS L N   1 
ATOM   2356 C  CA  . CYS B 2 89  ? 13.435  20.473 97.616  1.00 14.28 ? 104 CYS L CA  1 
ATOM   2357 C  C   . CYS B 2 89  ? 12.131  20.679 96.813  1.00 14.35 ? 104 CYS L C   1 
ATOM   2358 O  O   . CYS B 2 89  ? 11.357  21.606 97.083  1.00 15.31 ? 104 CYS L O   1 
ATOM   2359 C  CB  . CYS B 2 89  ? 13.281  19.343 98.629  1.00 15.70 ? 104 CYS L CB  1 
ATOM   2360 S  SG  . CYS B 2 89  ? 12.047  19.695 99.903  1.00 17.26 ? 104 CYS L SG  1 
ATOM   2361 N  N   . GLN B 2 90  ? 11.879  19.799 95.839  1.00 14.93 ? 105 GLN L N   1 
ATOM   2362 C  CA  . GLN B 2 90  ? 10.662  19.830 95.029  1.00 14.41 ? 105 GLN L CA  1 
ATOM   2363 C  C   . GLN B 2 90  ? 10.305  18.404 94.654  1.00 15.29 ? 105 GLN L C   1 
ATOM   2364 O  O   . GLN B 2 90  ? 11.202  17.654 94.247  1.00 16.40 ? 105 GLN L O   1 
ATOM   2365 C  CB  . GLN B 2 90  ? 10.916  20.606 93.738  1.00 15.04 ? 105 GLN L CB  1 
ATOM   2366 C  CG  . GLN B 2 90  ? 9.666   20.817 92.893  1.00 15.37 ? 105 GLN L CG  1 
ATOM   2367 C  CD  . GLN B 2 90  ? 9.908   21.201 91.463  1.00 15.79 ? 105 GLN L CD  1 
ATOM   2368 O  OE1 . GLN B 2 90  ? 10.980  20.975 90.925  1.00 18.31 ? 105 GLN L OE1 1 
ATOM   2369 N  NE2 . GLN B 2 90  ? 8.827   21.638 90.806  1.00 15.57 ? 105 GLN L NE2 1 
ATOM   2370 N  N   . GLN B 2 91  ? 9.033   18.058 94.757  1.00 15.99 ? 106 GLN L N   1 
ATOM   2371 C  CA  . GLN B 2 91  ? 8.597   16.794 94.187  1.00 14.48 ? 106 GLN L CA  1 
ATOM   2372 C  C   . GLN B 2 91  ? 7.940   17.041 92.832  1.00 15.55 ? 106 GLN L C   1 
ATOM   2373 O  O   . GLN B 2 91  ? 7.196   18.009 92.705  1.00 16.12 ? 106 GLN L O   1 
ATOM   2374 C  CB  . GLN B 2 91  ? 7.696   16.042 95.152  1.00 16.80 ? 106 GLN L CB  1 
ATOM   2375 C  CG  . GLN B 2 91  ? 6.334   16.652 95.409  1.00 16.15 ? 106 GLN L CG  1 
ATOM   2376 C  CD  . GLN B 2 91  ? 5.303   16.289 94.360  1.00 16.62 ? 106 GLN L CD  1 
ATOM   2377 O  OE1 . GLN B 2 91  ? 5.450   15.324 93.612  1.00 18.86 ? 106 GLN L OE1 1 
ATOM   2378 N  NE2 . GLN B 2 91  ? 4.216   17.044 94.358  1.00 17.64 ? 106 GLN L NE2 1 
ATOM   2379 N  N   . TYR B 2 92  ? 8.243   16.128 91.883  1.00 16.75 ? 107 TYR L N   1 
ATOM   2380 C  CA  . TYR B 2 92  ? 7.685   16.216 90.533  1.00 17.10 ? 107 TYR L CA  1 
ATOM   2381 C  C   . TYR B 2 92  ? 7.076   14.861 90.147  1.00 21.24 ? 107 TYR L C   1 
ATOM   2382 O  O   . TYR B 2 92  ? 6.962   14.534 88.947  1.00 21.36 ? 107 TYR L O   1 
ATOM   2383 C  CB  . TYR B 2 92  ? 8.716   16.753 89.538  1.00 18.01 ? 107 TYR L CB  1 
ATOM   2384 C  CG  . TYR B 2 92  ? 10.039  16.008 89.463  1.00 19.28 ? 107 TYR L CG  1 
ATOM   2385 C  CD1 . TYR B 2 92  ? 11.044  16.167 90.424  1.00 18.26 ? 107 TYR L CD1 1 
ATOM   2386 C  CD2 . TYR B 2 92  ? 10.346  15.164 88.406  1.00 19.17 ? 107 TYR L CD2 1 
ATOM   2387 C  CE1 . TYR B 2 92  ? 12.253  15.500 90.323  1.00 17.85 ? 107 TYR L CE1 1 
ATOM   2388 C  CE2 . TYR B 2 92  ? 11.551  14.486 88.310  1.00 20.24 ? 107 TYR L CE2 1 
ATOM   2389 C  CZ  . TYR B 2 92  ? 12.532  14.673 89.270  1.00 20.02 ? 107 TYR L CZ  1 
ATOM   2390 O  OH  . TYR B 2 92  ? 13.706  14.003 89.170  1.00 21.00 ? 107 TYR L OH  1 
ATOM   2391 N  N   . ASP B 2 93  ? 6.540   14.170 91.162  1.00 20.16 ? 108 ASP L N   1 
ATOM   2392 C  CA  . ASP B 2 93  ? 5.852   12.904 90.972  1.00 22.61 ? 108 ASP L CA  1 
ATOM   2393 C  C   . ASP B 2 93  ? 4.409   13.148 90.544  1.00 24.88 ? 108 ASP L C   1 
ATOM   2394 O  O   . ASP B 2 93  ? 3.921   12.495 89.630  1.00 24.83 ? 108 ASP L O   1 
ATOM   2395 C  CB  . ASP B 2 93  ? 5.908   12.123 92.287  1.00 25.21 ? 108 ASP L CB  1 
ATOM   2396 C  CG  . ASP B 2 93  ? 5.428   10.685 92.183  1.00 37.54 ? 108 ASP L CG  1 
ATOM   2397 O  OD1 . ASP B 2 93  ? 5.491   10.119 91.062  1.00 33.70 ? 108 ASP L OD1 1 
ATOM   2398 O  OD2 . ASP B 2 93  ? 5.029   10.145 93.225  1.00 37.60 ? 108 ASP L OD2 1 
ATOM   2399 N  N   . SER B 2 94  ? 3.747   14.089 91.221  1.00 23.82 ? 109 SER L N   1 
ATOM   2400 C  CA  . SER B 2 94  ? 2.312   14.276 91.139  1.00 23.73 ? 109 SER L CA  1 
ATOM   2401 C  C   . SER B 2 94  ? 1.954   15.758 91.221  1.00 21.72 ? 109 SER L C   1 
ATOM   2402 O  O   . SER B 2 94  ? 2.173   16.389 92.238  1.00 23.15 ? 109 SER L O   1 
ATOM   2403 C  CB  . SER B 2 94  ? 1.652   13.486 92.224  1.00 27.16 ? 109 SER L CB  1 
ATOM   2404 O  OG  . SER B 2 94  ? 0.272   13.741 92.206  1.00 33.39 ? 109 SER L OG  1 
ATOM   2405 N  N   . ALA B 2 95  ? 1.319   16.348 90.176  1.00 21.92 ? 114 ALA L N   1 
ATOM   2406 C  CA  . ALA B 2 95  ? 1.011   17.776 90.239  1.00 21.72 ? 114 ALA L CA  1 
ATOM   2407 C  C   . ALA B 2 95  ? 0.011   18.085 91.337  1.00 20.97 ? 114 ALA L C   1 
ATOM   2408 O  O   . ALA B 2 95  ? -0.888  17.279 91.586  1.00 23.33 ? 114 ALA L O   1 
ATOM   2409 C  CB  . ALA B 2 95  ? 0.456   18.256 88.912  1.00 23.26 ? 114 ALA L CB  1 
ATOM   2410 N  N   . PRO B 2 96  ? 0.052   19.265 91.992  1.00 20.95 ? 115 PRO L N   1 
ATOM   2411 C  CA  . PRO B 2 96  ? 1.074   20.306 91.776  1.00 22.07 ? 115 PRO L CA  1 
ATOM   2412 C  C   . PRO B 2 96  ? 2.479   19.883 92.220  1.00 19.66 ? 115 PRO L C   1 
ATOM   2413 O  O   . PRO B 2 96  ? 2.626   19.218 93.244  1.00 20.61 ? 115 PRO L O   1 
ATOM   2414 C  CB  . PRO B 2 96  ? 0.637   21.447 92.696  1.00 22.37 ? 115 PRO L CB  1 
ATOM   2415 C  CG  . PRO B 2 96  ? -0.253  20.785 93.741  1.00 24.65 ? 115 PRO L CG  1 
ATOM   2416 C  CD  . PRO B 2 96  ? -0.930  19.661 93.000  1.00 24.09 ? 115 PRO L CD  1 
ATOM   2417 N  N   . ASP B 2 97  ? 3.484   20.248 91.416  1.00 17.01 ? 116 ASP L N   1 
ATOM   2418 C  CA  . ASP B 2 97  ? 4.872   19.846 91.646  1.00 16.27 ? 116 ASP L CA  1 
ATOM   2419 C  C   . ASP B 2 97  ? 5.519   20.720 92.731  1.00 17.18 ? 116 ASP L C   1 
ATOM   2420 O  O   . ASP B 2 97  ? 6.305   21.613 92.411  1.00 16.44 ? 116 ASP L O   1 
ATOM   2421 C  CB  . ASP B 2 97  ? 5.690   19.829 90.364  1.00 16.89 ? 116 ASP L CB  1 
ATOM   2422 C  CG  . ASP B 2 97  ? 5.314   18.761 89.328  1.00 17.85 ? 116 ASP L CG  1 
ATOM   2423 O  OD1 . ASP B 2 97  ? 4.405   17.955 89.584  1.00 21.18 ? 116 ASP L OD1 1 
ATOM   2424 O  OD2 . ASP B 2 97  ? 6.019   18.700 88.332  1.00 19.48 ? 116 ASP L OD2 1 
ATOM   2425 N  N   . THR B 2 98  ? 5.132   20.442 93.986  1.00 16.31 ? 117 THR L N   1 
ATOM   2426 C  CA  . THR B 2 98  ? 5.327   21.351 95.101  1.00 16.05 ? 117 THR L CA  1 
ATOM   2427 C  C   . THR B 2 98  ? 6.775   21.465 95.550  1.00 15.11 ? 117 THR L C   1 
ATOM   2428 O  O   . THR B 2 98  ? 7.547   20.504 95.487  1.00 15.33 ? 117 THR L O   1 
ATOM   2429 C  CB  . THR B 2 98  ? 4.442   20.923 96.270  1.00 17.68 ? 117 THR L CB  1 
ATOM   2430 O  OG1 . THR B 2 98  ? 4.558   19.512 96.346  1.00 18.51 ? 117 THR L OG1 1 
ATOM   2431 C  CG2 . THR B 2 98  ? 3.007   21.329 96.046  1.00 19.88 ? 117 THR L CG2 1 
ATOM   2432 N  N   . PHE B 2 99  ? 7.114   22.665 96.021  1.00 15.57 ? 118 PHE L N   1 
ATOM   2433 C  CA  . PHE B 2 99  ? 8.378   22.958 96.679  1.00 14.86 ? 118 PHE L CA  1 
ATOM   2434 C  C   . PHE B 2 99  ? 8.221   22.965 98.200  1.00 16.01 ? 118 PHE L C   1 
ATOM   2435 O  O   . PHE B 2 99  ? 7.201   23.393 98.756  1.00 16.78 ? 118 PHE L O   1 
ATOM   2436 C  CB  . PHE B 2 99  ? 8.833   24.366 96.242  1.00 15.96 ? 118 PHE L CB  1 
ATOM   2437 C  CG  . PHE B 2 99  ? 9.317   24.444 94.815  1.00 15.60 ? 118 PHE L CG  1 
ATOM   2438 C  CD1 . PHE B 2 99  ? 10.651  24.209 94.510  1.00 16.08 ? 118 PHE L CD1 1 
ATOM   2439 C  CD2 . PHE B 2 99  ? 8.453   24.741 93.766  1.00 16.59 ? 118 PHE L CD2 1 
ATOM   2440 C  CE1 . PHE B 2 99  ? 11.097  24.249 93.197  1.00 17.74 ? 118 PHE L CE1 1 
ATOM   2441 C  CE2 . PHE B 2 99  ? 8.899   24.774 92.455  1.00 17.47 ? 118 PHE L CE2 1 
ATOM   2442 C  CZ  . PHE B 2 99  ? 10.213  24.526 92.161  1.00 16.16 ? 118 PHE L CZ  1 
ATOM   2443 N  N   . GLY B 2 100 ? 9.303   22.577 98.860  1.00 15.59 ? 119 GLY L N   1 
ATOM   2444 C  CA  . GLY B 2 100 ? 9.455   22.931 100.253 1.00 15.72 ? 119 GLY L CA  1 
ATOM   2445 C  C   . GLY B 2 100 ? 9.685   24.422 100.423 1.00 14.22 ? 119 GLY L C   1 
ATOM   2446 O  O   . GLY B 2 100 ? 9.913   25.153 99.454  1.00 14.72 ? 119 GLY L O   1 
ATOM   2447 N  N   . GLN B 2 101 ? 9.796   24.829 101.705 1.00 15.53 ? 120 GLN L N   1 
ATOM   2448 C  CA  . GLN B 2 101 ? 9.881   26.233 102.033 1.00 16.39 ? 120 GLN L CA  1 
ATOM   2449 C  C   . GLN B 2 101 ? 11.309  26.763 102.058 1.00 16.58 ? 120 GLN L C   1 
ATOM   2450 O  O   . GLN B 2 101 ? 11.461  27.966 102.206 1.00 17.33 ? 120 GLN L O   1 
ATOM   2451 C  CB  . GLN B 2 101 ? 9.130   26.551 103.338 1.00 19.76 ? 120 GLN L CB  1 
ATOM   2452 C  CG  . GLN B 2 101 ? 9.897   26.185 104.573 1.00 24.22 ? 120 GLN L CG  1 
ATOM   2453 C  CD  . GLN B 2 101 ? 9.923   24.721 104.966 1.00 25.41 ? 120 GLN L CD  1 
ATOM   2454 O  OE1 . GLN B 2 101 ? 9.445   23.776 104.307 1.00 21.66 ? 120 GLN L OE1 1 
ATOM   2455 N  NE2 . GLN B 2 101 ? 10.525  24.539 106.140 1.00 34.07 ? 120 GLN L NE2 1 
ATOM   2456 N  N   . GLY B 2 102 ? 12.290  25.885 101.874 1.00 14.24 ? 121 GLY L N   1 
ATOM   2457 C  CA  . GLY B 2 102 ? 13.697  26.240 101.802 1.00 14.72 ? 121 GLY L CA  1 
ATOM   2458 C  C   . GLY B 2 102 ? 14.414  26.158 103.137 1.00 16.81 ? 121 GLY L C   1 
ATOM   2459 O  O   . GLY B 2 102 ? 13.828  26.376 104.193 1.00 17.11 ? 121 GLY L O   1 
ATOM   2460 N  N   . THR B 2 103 ? 15.707  25.840 103.074 1.00 14.49 ? 122 THR L N   1 
ATOM   2461 C  CA  . THR B 2 103 ? 16.636  25.959 104.179 1.00 14.98 ? 122 THR L CA  1 
ATOM   2462 C  C   . THR B 2 103 ? 17.689  26.972 103.763 1.00 14.84 ? 122 THR L C   1 
ATOM   2463 O  O   . THR B 2 103 ? 18.390  26.765 102.763 1.00 15.48 ? 122 THR L O   1 
ATOM   2464 C  CB  . THR B 2 103 ? 17.295  24.617 104.497 1.00 16.24 ? 122 THR L CB  1 
ATOM   2465 O  OG1 . THR B 2 103 ? 16.313  23.693 104.956 1.00 17.73 ? 122 THR L OG1 1 
ATOM   2466 C  CG2 . THR B 2 103 ? 18.432  24.776 105.483 1.00 16.97 ? 122 THR L CG2 1 
ATOM   2467 N  N   . ARG B 2 104 ? 17.811  28.030 104.561 1.00 14.06 ? 123 ARG L N   1 
ATOM   2468 C  CA  . ARG B 2 104 ? 18.848  29.032 104.330 1.00 15.45 ? 123 ARG L CA  1 
ATOM   2469 C  C   . ARG B 2 104 ? 20.119  28.577 105.037 1.00 15.31 ? 123 ARG L C   1 
ATOM   2470 O  O   . ARG B 2 104 ? 20.171  28.572 106.266 1.00 16.63 ? 123 ARG L O   1 
ATOM   2471 C  CB  A ARG B 2 104 ? 18.456  30.431 104.816 0.50 16.17 ? 123 ARG L CB  1 
ATOM   2472 C  CB  B ARG B 2 104 ? 18.475  30.430 104.849 0.50 16.27 ? 123 ARG L CB  1 
ATOM   2473 C  CG  A ARG B 2 104 ? 19.384  31.510 104.265 0.50 18.88 ? 123 ARG L CG  1 
ATOM   2474 C  CG  B ARG B 2 104 ? 19.552  31.488 104.597 0.50 19.43 ? 123 ARG L CG  1 
ATOM   2475 C  CD  A ARG B 2 104 ? 19.033  32.933 104.670 0.50 22.61 ? 123 ARG L CD  1 
ATOM   2476 C  CD  B ARG B 2 104 ? 19.255  32.878 105.169 0.50 22.68 ? 123 ARG L CD  1 
ATOM   2477 N  NE  A ARG B 2 104 ? 17.654  33.255 104.379 0.50 25.93 ? 123 ARG L NE  1 
ATOM   2478 N  NE  B ARG B 2 104 ? 20.311  33.886 104.948 0.50 23.16 ? 123 ARG L NE  1 
ATOM   2479 C  CZ  A ARG B 2 104 ? 17.181  33.693 103.217 0.50 25.86 ? 123 ARG L CZ  1 
ATOM   2480 C  CZ  B ARG B 2 104 ? 21.350  34.116 105.758 0.50 23.54 ? 123 ARG L CZ  1 
ATOM   2481 N  NH1 A ARG B 2 104 ? 17.998  34.106 102.264 0.50 24.19 ? 123 ARG L NH1 1 
ATOM   2482 N  NH1 B ARG B 2 104 ? 21.441  33.519 106.932 0.50 20.10 ? 123 ARG L NH1 1 
ATOM   2483 N  NH2 A ARG B 2 104 ? 15.873  33.755 103.058 0.50 23.08 ? 123 ARG L NH2 1 
ATOM   2484 N  NH2 B ARG B 2 104 ? 22.267  35.017 105.423 0.50 21.15 ? 123 ARG L NH2 1 
ATOM   2485 N  N   . LEU B 2 105 ? 21.158  28.279 104.232 1.00 14.33 ? 124 LEU L N   1 
ATOM   2486 C  CA  . LEU B 2 105 ? 22.470  27.912 104.716 1.00 14.05 ? 124 LEU L CA  1 
ATOM   2487 C  C   . LEU B 2 105 ? 23.383  29.123 104.580 1.00 14.23 ? 124 LEU L C   1 
ATOM   2488 O  O   . LEU B 2 105 ? 23.587  29.652 103.492 1.00 15.09 ? 124 LEU L O   1 
ATOM   2489 C  CB  . LEU B 2 105 ? 23.023  26.754 103.887 1.00 14.13 ? 124 LEU L CB  1 
ATOM   2490 C  CG  . LEU B 2 105 ? 24.475  26.349 104.158 1.00 14.52 ? 124 LEU L CG  1 
ATOM   2491 C  CD1 . LEU B 2 105 ? 24.610  25.818 105.598 1.00 15.94 ? 124 LEU L CD1 1 
ATOM   2492 C  CD2 . LEU B 2 105 ? 24.940  25.322 103.156 1.00 15.66 ? 124 LEU L CD2 1 
ATOM   2493 N  N   . GLU B 2 106 ? 23.959  29.536 105.713 1.00 14.63 ? 125 GLU L N   1 
ATOM   2494 C  CA  . GLU B 2 106 ? 25.005  30.530 105.787 1.00 16.47 ? 125 GLU L CA  1 
ATOM   2495 C  C   . GLU B 2 106 ? 26.325  29.860 106.124 1.00 15.44 ? 125 GLU L C   1 
ATOM   2496 O  O   . GLU B 2 106 ? 26.310  28.848 106.828 1.00 15.15 ? 125 GLU L O   1 
ATOM   2497 C  CB  . GLU B 2 106 ? 24.616  31.477 106.945 1.00 22.61 ? 125 GLU L CB  1 
ATOM   2498 C  CG  . GLU B 2 106 ? 25.728  32.398 107.324 1.00 29.61 ? 125 GLU L CG  1 
ATOM   2499 C  CD  . GLU B 2 106 ? 25.584  33.096 108.651 1.00 27.29 ? 125 GLU L CD  1 
ATOM   2500 O  OE1 . GLU B 2 106 ? 25.377  34.285 108.585 1.00 27.13 ? 125 GLU L OE1 1 
ATOM   2501 O  OE2 . GLU B 2 106 ? 25.777  32.457 109.746 1.00 23.95 ? 125 GLU L OE2 1 
ATOM   2502 N  N   . ILE B 2 107 ? 27.407  30.419 105.588 1.00 16.39 ? 126 ILE L N   1 
ATOM   2503 C  CA  . ILE B 2 107 ? 28.750  29.965 105.890 1.00 16.27 ? 126 ILE L CA  1 
ATOM   2504 C  C   . ILE B 2 107 ? 29.259  30.720 107.105 1.00 17.40 ? 126 ILE L C   1 
ATOM   2505 O  O   . ILE B 2 107 ? 29.382  31.941 107.081 1.00 18.82 ? 126 ILE L O   1 
ATOM   2506 C  CB  . ILE B 2 107 ? 29.684  30.057 104.680 1.00 18.43 ? 126 ILE L CB  1 
ATOM   2507 C  CG1 . ILE B 2 107 ? 29.127  29.225 103.516 1.00 18.61 ? 126 ILE L CG1 1 
ATOM   2508 C  CG2 . ILE B 2 107 ? 31.079  29.650 105.152 1.00 18.94 ? 126 ILE L CG2 1 
ATOM   2509 C  CD1 . ILE B 2 107 ? 28.958  27.754 103.741 1.00 20.88 ? 126 ILE L CD1 1 
ATOM   2510 N  N   . LYS B 2 108 ? 29.504  29.989 108.183 1.00 16.66 ? 127 LYS L N   1 
ATOM   2511 C  CA  . LYS B 2 108 ? 30.077  30.537 109.409 1.00 16.91 ? 127 LYS L CA  1 
ATOM   2512 C  C   . LYS B 2 108 ? 31.564  30.824 109.182 1.00 18.73 ? 127 LYS L C   1 
ATOM   2513 O  O   . LYS B 2 108 ? 32.301  30.108 108.480 1.00 21.55 ? 127 LYS L O   1 
ATOM   2514 C  CB  . LYS B 2 108 ? 29.771  29.588 110.576 1.00 16.48 ? 127 LYS L CB  1 
ATOM   2515 C  CG  . LYS B 2 108 ? 30.238  30.031 111.955 1.00 21.36 ? 127 LYS L CG  1 
ATOM   2516 C  CD  . LYS B 2 108 ? 29.739  29.141 113.054 1.00 26.01 ? 127 LYS L CD  1 
ATOM   2517 C  CE  . LYS B 2 108 ? 28.212  29.250 113.162 1.00 33.49 ? 127 LYS L CE  1 
ATOM   2518 N  NZ  . LYS B 2 108 ? 27.709  29.213 114.556 1.00 48.23 ? 127 LYS L NZ  1 
ATOM   2519 N  N   . ARG B 2 109 ? 32.004  31.983 109.703 1.00 17.58 ? 128 ARG L N   1 
ATOM   2520 C  CA  . ARG B 2 109 ? 33.416  32.279 109.822 1.00 16.46 ? 128 ARG L CA  1 
ATOM   2521 C  C   . ARG B 2 109 ? 33.674  32.891 111.186 1.00 18.27 ? 128 ARG L C   1 
ATOM   2522 O  O   . ARG B 2 109 ? 32.761  33.065 111.975 1.00 18.31 ? 128 ARG L O   1 
ATOM   2523 C  CB  . ARG B 2 109 ? 33.863  33.235 108.716 1.00 18.28 ? 128 ARG L CB  1 
ATOM   2524 C  CG  . ARG B 2 109 ? 33.120  34.563 108.728 1.00 19.93 ? 128 ARG L CG  1 
ATOM   2525 C  CD  . ARG B 2 109 ? 33.891  35.674 108.044 1.00 21.35 ? 128 ARG L CD  1 
ATOM   2526 N  NE  . ARG B 2 109 ? 35.072  35.942 108.872 1.00 21.39 ? 128 ARG L NE  1 
ATOM   2527 C  CZ  . ARG B 2 109 ? 36.286  36.242 108.460 1.00 21.28 ? 128 ARG L CZ  1 
ATOM   2528 N  NH1 . ARG B 2 109 ? 36.543  36.357 107.177 1.00 21.00 ? 128 ARG L NH1 1 
ATOM   2529 N  NH2 . ARG B 2 109 ? 37.256  36.471 109.331 1.00 23.45 ? 128 ARG L NH2 1 
ATOM   2530 N  N   . THR B 2 110 ? 34.958  33.096 111.487 1.00 18.00 ? 129 THR L N   1 
ATOM   2531 C  CA  . THR B 2 110 ? 35.313  33.731 112.745 1.00 18.66 ? 129 THR L CA  1 
ATOM   2532 C  C   . THR B 2 110 ? 34.889  35.199 112.739 1.00 18.17 ? 129 THR L C   1 
ATOM   2533 O  O   . THR B 2 110 ? 34.747  35.839 111.701 1.00 18.98 ? 129 THR L O   1 
ATOM   2534 C  CB  . THR B 2 110 ? 36.785  33.501 113.073 1.00 18.90 ? 129 THR L CB  1 
ATOM   2535 O  OG1 . THR B 2 110 ? 37.562  34.060 112.033 1.00 20.21 ? 129 THR L OG1 1 
ATOM   2536 C  CG2 . THR B 2 110 ? 37.093  32.025 113.220 1.00 20.10 ? 129 THR L CG2 1 
ATOM   2537 N  N   . VAL B 2 111 ? 34.740  35.731 113.959 1.00 19.36 ? 130 VAL L N   1 
ATOM   2538 C  CA  . VAL B 2 111 ? 34.173  37.072 114.093 1.00 21.61 ? 130 VAL L CA  1 
ATOM   2539 C  C   . VAL B 2 111 ? 35.004  38.079 113.302 1.00 22.78 ? 130 VAL L C   1 
ATOM   2540 O  O   . VAL B 2 111 ? 36.240  38.070 113.382 1.00 24.59 ? 130 VAL L O   1 
ATOM   2541 C  CB  . VAL B 2 111 ? 34.050  37.469 115.563 1.00 22.64 ? 130 VAL L CB  1 
ATOM   2542 C  CG1 . VAL B 2 111 ? 35.409  37.755 116.198 1.00 28.74 ? 130 VAL L CG1 1 
ATOM   2543 C  CG2 . VAL B 2 111 ? 33.111  38.656 115.767 1.00 24.85 ? 130 VAL L CG2 1 
ATOM   2544 N  N   . ALA B 2 112 ? 34.317  39.018 112.640 1.00 19.35 ? 131 ALA L N   1 
ATOM   2545 C  CA  . ALA B 2 112 ? 34.968  40.050 111.849 1.00 18.44 ? 131 ALA L CA  1 
ATOM   2546 C  C   . ALA B 2 112 ? 34.250  41.378 112.017 1.00 18.54 ? 131 ALA L C   1 
ATOM   2547 O  O   . ALA B 2 112 ? 33.071  41.501 111.701 1.00 19.17 ? 131 ALA L O   1 
ATOM   2548 C  CB  . ALA B 2 112 ? 35.007  39.706 110.401 1.00 19.69 ? 131 ALA L CB  1 
ATOM   2549 N  N   . ALA B 2 113 ? 34.946  42.358 112.606 1.00 17.96 ? 132 ALA L N   1 
ATOM   2550 C  CA  . ALA B 2 113 ? 34.298  43.610 112.919 1.00 17.32 ? 132 ALA L CA  1 
ATOM   2551 C  C   . ALA B 2 113 ? 34.087  44.439 111.671 1.00 16.39 ? 132 ALA L C   1 
ATOM   2552 O  O   . ALA B 2 113 ? 34.929  44.446 110.782 1.00 18.84 ? 132 ALA L O   1 
ATOM   2553 C  CB  . ALA B 2 113 ? 35.138  44.418 113.914 1.00 18.16 ? 132 ALA L CB  1 
ATOM   2554 N  N   . PRO B 2 114 ? 33.022  45.285 111.625 1.00 17.12 ? 133 PRO L N   1 
ATOM   2555 C  CA  . PRO B 2 114 ? 32.854  46.177 110.474 1.00 16.75 ? 133 PRO L CA  1 
ATOM   2556 C  C   . PRO B 2 114 ? 33.779  47.399 110.472 1.00 19.27 ? 133 PRO L C   1 
ATOM   2557 O  O   . PRO B 2 114 ? 34.103  47.925 111.554 1.00 20.89 ? 133 PRO L O   1 
ATOM   2558 C  CB  . PRO B 2 114 ? 31.431  46.712 110.641 1.00 18.56 ? 133 PRO L CB  1 
ATOM   2559 C  CG  . PRO B 2 114 ? 31.165  46.607 112.076 1.00 18.35 ? 133 PRO L CG  1 
ATOM   2560 C  CD  . PRO B 2 114 ? 31.932  45.393 112.592 1.00 17.21 ? 133 PRO L CD  1 
ATOM   2561 N  N   . SER B 2 115 ? 34.140  47.821 109.256 1.00 18.22 ? 134 SER L N   1 
ATOM   2562 C  CA  . SER B 2 115 ? 34.624  49.170 109.018 1.00 20.31 ? 134 SER L CA  1 
ATOM   2563 C  C   . SER B 2 115 ? 33.405  50.063 108.823 1.00 19.61 ? 134 SER L C   1 
ATOM   2564 O  O   . SER B 2 115 ? 32.491  49.695 108.092 1.00 21.96 ? 134 SER L O   1 
ATOM   2565 C  CB  . SER B 2 115 ? 35.590  49.156 107.842 1.00 23.15 ? 134 SER L CB  1 
ATOM   2566 O  OG  . SER B 2 115 ? 36.667  48.252 108.149 1.00 26.67 ? 134 SER L OG  1 
ATOM   2567 N  N   . VAL B 2 116 ? 33.375  51.206 109.508 1.00 17.78 ? 135 VAL L N   1 
ATOM   2568 C  CA  . VAL B 2 116 ? 32.215  52.084 109.441 1.00 18.62 ? 135 VAL L CA  1 
ATOM   2569 C  C   . VAL B 2 116 ? 32.590  53.408 108.780 1.00 19.11 ? 135 VAL L C   1 
ATOM   2570 O  O   . VAL B 2 116 ? 33.559  54.018 109.219 1.00 21.61 ? 135 VAL L O   1 
ATOM   2571 C  CB  . VAL B 2 116 ? 31.687  52.343 110.856 1.00 16.86 ? 135 VAL L CB  1 
ATOM   2572 C  CG1 . VAL B 2 116 ? 30.414  53.148 110.832 1.00 19.11 ? 135 VAL L CG1 1 
ATOM   2573 C  CG2 . VAL B 2 116 ? 31.462  51.046 111.617 1.00 17.02 ? 135 VAL L CG2 1 
ATOM   2574 N  N   . PHE B 2 117 ? 31.750  53.834 107.862 1.00 18.87 ? 136 PHE L N   1 
ATOM   2575 C  CA  . PHE B 2 117 ? 31.937  55.084 107.131 1.00 19.37 ? 136 PHE L CA  1 
ATOM   2576 C  C   . PHE B 2 117 ? 30.607  55.833 107.054 1.00 21.13 ? 136 PHE L C   1 
ATOM   2577 O  O   . PHE B 2 117 ? 29.554  55.247 106.802 1.00 22.79 ? 136 PHE L O   1 
ATOM   2578 C  CB  . PHE B 2 117 ? 32.504  54.785 105.738 1.00 22.63 ? 136 PHE L CB  1 
ATOM   2579 C  CG  . PHE B 2 117 ? 33.689  53.859 105.731 1.00 23.24 ? 136 PHE L CG  1 
ATOM   2580 C  CD1 . PHE B 2 117 ? 34.889  54.219 106.351 1.00 25.31 ? 136 PHE L CD1 1 
ATOM   2581 C  CD2 . PHE B 2 117 ? 33.625  52.629 105.109 1.00 26.62 ? 136 PHE L CD2 1 
ATOM   2582 C  CE1 . PHE B 2 117 ? 36.007  53.388 106.325 1.00 26.13 ? 136 PHE L CE1 1 
ATOM   2583 C  CE2 . PHE B 2 117 ? 34.738  51.807 105.090 1.00 27.41 ? 136 PHE L CE2 1 
ATOM   2584 C  CZ  . PHE B 2 117 ? 35.914  52.164 105.734 1.00 25.91 ? 136 PHE L CZ  1 
ATOM   2585 N  N   . ILE B 2 118 ? 30.649  57.175 107.250 1.00 22.22 ? 137 ILE L N   1 
ATOM   2586 C  CA  . ILE B 2 118 ? 29.452  58.013 107.167 1.00 20.89 ? 137 ILE L CA  1 
ATOM   2587 C  C   . ILE B 2 118 ? 29.601  58.984 105.973 1.00 22.63 ? 137 ILE L C   1 
ATOM   2588 O  O   . ILE B 2 118 ? 30.684  59.483 105.665 1.00 24.31 ? 137 ILE L O   1 
ATOM   2589 C  CB  . ILE B 2 118 ? 29.130  58.727 108.498 1.00 21.42 ? 137 ILE L CB  1 
ATOM   2590 C  CG1 . ILE B 2 118 ? 27.726  59.325 108.508 1.00 22.76 ? 137 ILE L CG1 1 
ATOM   2591 C  CG2 . ILE B 2 118 ? 30.161  59.793 108.864 1.00 21.96 ? 137 ILE L CG2 1 
ATOM   2592 C  CD1 . ILE B 2 118 ? 27.228  59.715 109.860 1.00 21.45 ? 137 ILE L CD1 1 
ATOM   2593 N  N   . PHE B 2 119 ? 28.507  59.147 105.231 1.00 20.79 ? 138 PHE L N   1 
ATOM   2594 C  CA  . PHE B 2 119 ? 28.460  59.985 104.033 1.00 21.02 ? 138 PHE L CA  1 
ATOM   2595 C  C   . PHE B 2 119 ? 27.367  61.020 104.214 1.00 23.55 ? 138 PHE L C   1 
ATOM   2596 O  O   . PHE B 2 119 ? 26.199  60.666 104.323 1.00 23.39 ? 138 PHE L O   1 
ATOM   2597 C  CB  . PHE B 2 119 ? 28.146  59.178 102.775 1.00 23.25 ? 138 PHE L CB  1 
ATOM   2598 C  CG  . PHE B 2 119 ? 29.211  58.193 102.389 1.00 23.45 ? 138 PHE L CG  1 
ATOM   2599 C  CD1 . PHE B 2 119 ? 29.191  56.901 102.892 1.00 23.57 ? 138 PHE L CD1 1 
ATOM   2600 C  CD2 . PHE B 2 119 ? 30.230  58.561 101.538 1.00 21.93 ? 138 PHE L CD2 1 
ATOM   2601 C  CE1 . PHE B 2 119 ? 30.152  55.981 102.507 1.00 25.52 ? 138 PHE L CE1 1 
ATOM   2602 C  CE2 . PHE B 2 119 ? 31.209  57.645 101.169 1.00 23.02 ? 138 PHE L CE2 1 
ATOM   2603 C  CZ  . PHE B 2 119 ? 31.173  56.362 101.659 1.00 24.64 ? 138 PHE L CZ  1 
ATOM   2604 N  N   . PRO B 2 120 ? 27.691  62.341 104.297 1.00 23.05 ? 139 PRO L N   1 
ATOM   2605 C  CA  . PRO B 2 120 ? 26.638  63.353 104.279 1.00 24.55 ? 139 PRO L CA  1 
ATOM   2606 C  C   . PRO B 2 120 ? 25.785  63.292 103.016 1.00 20.23 ? 139 PRO L C   1 
ATOM   2607 O  O   . PRO B 2 120 ? 26.220  62.812 101.971 1.00 22.42 ? 139 PRO L O   1 
ATOM   2608 C  CB  . PRO B 2 120 ? 27.441  64.670 104.352 1.00 21.86 ? 139 PRO L CB  1 
ATOM   2609 C  CG  . PRO B 2 120 ? 28.721  64.259 105.046 1.00 24.15 ? 139 PRO L CG  1 
ATOM   2610 C  CD  . PRO B 2 120 ? 29.035  62.918 104.411 1.00 22.62 ? 139 PRO L CD  1 
ATOM   2611 N  N   . PRO B 2 121 ? 24.599  63.941 103.023 1.00 21.16 ? 140 PRO L N   1 
ATOM   2612 C  CA  . PRO B 2 121 ? 23.853  64.178 101.783 1.00 25.53 ? 140 PRO L CA  1 
ATOM   2613 C  C   . PRO B 2 121 ? 24.711  64.986 100.800 1.00 26.30 ? 140 PRO L C   1 
ATOM   2614 O  O   . PRO B 2 121 ? 25.541  65.816 101.199 1.00 26.92 ? 140 PRO L O   1 
ATOM   2615 C  CB  . PRO B 2 121 ? 22.608  64.947 102.239 1.00 22.48 ? 140 PRO L CB  1 
ATOM   2616 C  CG  . PRO B 2 121 ? 22.954  65.527 103.592 1.00 26.90 ? 140 PRO L CG  1 
ATOM   2617 C  CD  . PRO B 2 121 ? 24.012  64.620 104.182 1.00 24.40 ? 140 PRO L CD  1 
ATOM   2618 N  N   . SER B 2 122 ? 24.550  64.689 99.518  1.00 25.67 ? 141 SER L N   1 
ATOM   2619 C  CA  . SER B 2 122 ? 25.193  65.436 98.446  1.00 29.72 ? 141 SER L CA  1 
ATOM   2620 C  C   . SER B 2 122 ? 24.543  66.811 98.360  1.00 31.48 ? 141 SER L C   1 
ATOM   2621 O  O   . SER B 2 122 ? 23.377  66.957 98.707  1.00 29.57 ? 141 SER L O   1 
ATOM   2622 C  CB  . SER B 2 122 ? 25.099  64.715 97.135  1.00 28.66 ? 141 SER L CB  1 
ATOM   2623 O  OG  . SER B 2 122 ? 23.765  64.734 96.627  1.00 29.04 ? 141 SER L OG  1 
ATOM   2624 N  N   . ASP B 2 123 ? 25.325  67.813 97.917  1.00 35.54 ? 142 ASP L N   1 
ATOM   2625 C  CA  . ASP B 2 123 ? 24.777  69.123 97.584  1.00 38.87 ? 142 ASP L CA  1 
ATOM   2626 C  C   . ASP B 2 123 ? 23.618  68.998 96.592  1.00 35.20 ? 142 ASP L C   1 
ATOM   2627 O  O   . ASP B 2 123 ? 22.549  69.576 96.789  1.00 39.48 ? 142 ASP L O   1 
ATOM   2628 C  CB  . ASP B 2 123 ? 25.875  70.037 97.031  1.00 46.12 ? 142 ASP L CB  1 
ATOM   2629 C  CG  . ASP B 2 123 ? 26.645  70.762 98.121  1.00 51.63 ? 142 ASP L CG  1 
ATOM   2630 O  OD1 . ASP B 2 123 ? 26.545  70.349 99.297  1.00 59.89 ? 142 ASP L OD1 1 
ATOM   2631 O  OD2 . ASP B 2 123 ? 27.314  71.756 97.791  1.00 65.04 ? 142 ASP L OD2 1 
ATOM   2632 N  N   . GLU B 2 124 ? 23.821  68.193 95.548  1.00 34.85 ? 143 GLU L N   1 
ATOM   2633 C  CA  . GLU B 2 124 ? 22.791  68.011 94.535  1.00 36.66 ? 143 GLU L CA  1 
ATOM   2634 C  C   . GLU B 2 124 ? 21.469  67.613 95.187  1.00 37.38 ? 143 GLU L C   1 
ATOM   2635 O  O   . GLU B 2 124 ? 20.416  68.158 94.883  1.00 37.13 ? 143 GLU L O   1 
ATOM   2636 C  CB  . GLU B 2 124 ? 23.297  66.981 93.538  1.00 40.02 ? 143 GLU L CB  1 
ATOM   2637 C  CG  . GLU B 2 124 ? 22.353  66.720 92.384  1.00 45.26 ? 143 GLU L CG  1 
ATOM   2638 C  CD  . GLU B 2 124 ? 22.925  65.723 91.390  1.00 50.55 ? 143 GLU L CD  1 
ATOM   2639 O  OE1 . GLU B 2 124 ? 22.185  65.284 90.490  1.00 63.73 ? 143 GLU L OE1 1 
ATOM   2640 O  OE2 . GLU B 2 124 ? 24.107  65.360 91.532  1.00 54.89 ? 143 GLU L OE2 1 
ATOM   2641 N  N   . GLN B 2 125 ? 21.484  66.633 96.099  1.00 34.32 ? 144 GLN L N   1 
ATOM   2642 C  CA  . GLN B 2 125 ? 20.224  66.176 96.649  1.00 29.45 ? 144 GLN L CA  1 
ATOM   2643 C  C   . GLN B 2 125 ? 19.574  67.253 97.519  1.00 32.70 ? 144 GLN L C   1 
ATOM   2644 O  O   . GLN B 2 125 ? 18.366  67.428 97.510  1.00 32.38 ? 144 GLN L O   1 
ATOM   2645 C  CB  . GLN B 2 125 ? 20.417  64.865 97.417  1.00 28.72 ? 144 GLN L CB  1 
ATOM   2646 C  CG  . GLN B 2 125 ? 19.120  64.387 98.021  1.00 28.13 ? 144 GLN L CG  1 
ATOM   2647 C  CD  . GLN B 2 125 ? 19.272  63.255 99.007  1.00 29.50 ? 144 GLN L CD  1 
ATOM   2648 O  OE1 . GLN B 2 125 ? 20.327  63.068 99.616  1.00 25.56 ? 144 GLN L OE1 1 
ATOM   2649 N  NE2 . GLN B 2 125 ? 18.187  62.540 99.222  1.00 29.94 ? 144 GLN L NE2 1 
ATOM   2650 N  N   . LEU B 2 126 ? 20.358  67.973 98.310  1.00 32.04 ? 145 LEU L N   1 
ATOM   2651 C  CA  . LEU B 2 126 ? 19.773  68.951 99.218  1.00 37.32 ? 145 LEU L CA  1 
ATOM   2652 C  C   . LEU B 2 126 ? 18.990  70.011 98.432  1.00 42.64 ? 145 LEU L C   1 
ATOM   2653 O  O   . LEU B 2 126 ? 17.931  70.459 98.887  1.00 47.04 ? 145 LEU L O   1 
ATOM   2654 C  CB  . LEU B 2 126 ? 20.909  69.551 100.050 1.00 38.60 ? 145 LEU L CB  1 
ATOM   2655 C  CG  . LEU B 2 126 ? 21.422  68.616 101.147 1.00 39.45 ? 145 LEU L CG  1 
ATOM   2656 C  CD1 . LEU B 2 126 ? 22.698  69.146 101.804 1.00 38.48 ? 145 LEU L CD1 1 
ATOM   2657 C  CD2 . LEU B 2 126 ? 20.333  68.354 102.183 1.00 41.00 ? 145 LEU L CD2 1 
ATOM   2658 N  N   . LYS B 2 127 ? 19.495  70.343 97.237  1.00 44.20 ? 146 LYS L N   1 
ATOM   2659 C  CA  . LYS B 2 127 ? 18.809  71.227 96.302  1.00 56.22 ? 146 LYS L CA  1 
ATOM   2660 C  C   . LYS B 2 127 ? 17.314  70.934 96.264  1.00 54.10 ? 146 LYS L C   1 
ATOM   2661 O  O   . LYS B 2 127 ? 16.514  71.863 96.224  1.00 56.47 ? 146 LYS L O   1 
ATOM   2662 C  CB  . LYS B 2 127 ? 19.291  71.038 94.860  1.00 58.29 ? 146 LYS L CB  1 
ATOM   2663 C  CG  . LYS B 2 127 ? 20.644  71.634 94.486  1.00 63.94 ? 146 LYS L CG  1 
ATOM   2664 C  CD  . LYS B 2 127 ? 20.551  72.761 93.462  1.00 72.40 ? 146 LYS L CD  1 
ATOM   2665 C  CE  . LYS B 2 127 ? 21.754  72.851 92.542  1.00 77.14 ? 146 LYS L CE  1 
ATOM   2666 N  NZ  . LYS B 2 127 ? 22.997  73.190 93.279  1.00 77.94 ? 146 LYS L NZ  1 
ATOM   2667 N  N   . SER B 2 128 ? 16.945  69.649 96.252  1.00 52.66 ? 147 SER L N   1 
ATOM   2668 C  CA  . SER B 2 128 ? 15.587  69.250 95.916  1.00 52.42 ? 147 SER L CA  1 
ATOM   2669 C  C   . SER B 2 128 ? 14.751  68.854 97.137  1.00 50.12 ? 147 SER L C   1 
ATOM   2670 O  O   . SER B 2 128 ? 13.724  68.201 96.967  1.00 55.11 ? 147 SER L O   1 
ATOM   2671 C  CB  . SER B 2 128 ? 15.616  68.152 94.886  1.00 53.67 ? 147 SER L CB  1 
ATOM   2672 O  OG  . SER B 2 128 ? 16.743  67.304 95.079  1.00 62.17 ? 147 SER L OG  1 
ATOM   2673 N  N   . GLY B 2 129 ? 15.151  69.242 98.360  1.00 41.44 ? 148 GLY L N   1 
ATOM   2674 C  CA  . GLY B 2 129 ? 14.209  69.221 99.471  1.00 40.62 ? 148 GLY L CA  1 
ATOM   2675 C  C   . GLY B 2 129 ? 14.390  68.079 100.471 1.00 36.04 ? 148 GLY L C   1 
ATOM   2676 O  O   . GLY B 2 129 ? 13.682  68.041 101.488 1.00 35.74 ? 148 GLY L O   1 
ATOM   2677 N  N   . THR B 2 130 ? 15.318  67.152 100.181 1.00 37.08 ? 149 THR L N   1 
ATOM   2678 C  CA  . THR B 2 130 ? 15.480  65.961 101.018 1.00 38.70 ? 149 THR L CA  1 
ATOM   2679 C  C   . THR B 2 130 ? 16.964  65.697 101.289 1.00 33.53 ? 149 THR L C   1 
ATOM   2680 O  O   . THR B 2 130 ? 17.828  66.049 100.485 1.00 33.60 ? 149 THR L O   1 
ATOM   2681 C  CB  . THR B 2 130 ? 14.754  64.767 100.378 1.00 44.17 ? 149 THR L CB  1 
ATOM   2682 O  OG1 . THR B 2 130 ? 13.340  65.012 100.458 1.00 45.31 ? 149 THR L OG1 1 
ATOM   2683 C  CG2 . THR B 2 130 ? 15.055  63.450 101.066 1.00 44.24 ? 149 THR L CG2 1 
ATOM   2684 N  N   . ALA B 2 131 ? 17.233  65.040 102.441 1.00 32.72 ? 150 ALA L N   1 
ATOM   2685 C  CA  . ALA B 2 131 ? 18.583  64.699 102.870 1.00 30.69 ? 150 ALA L CA  1 
ATOM   2686 C  C   . ALA B 2 131 ? 18.643  63.212 103.224 1.00 24.92 ? 150 ALA L C   1 
ATOM   2687 O  O   . ALA B 2 131 ? 17.876  62.752 104.072 1.00 27.48 ? 150 ALA L O   1 
ATOM   2688 C  CB  . ALA B 2 131 ? 18.975  65.559 104.047 1.00 32.97 ? 150 ALA L CB  1 
ATOM   2689 N  N   . SER B 2 132 ? 19.460  62.470 102.477 1.00 23.91 ? 151 SER L N   1 
ATOM   2690 C  CA  . SER B 2 132 ? 19.781  61.086 102.797 1.00 22.53 ? 151 SER L CA  1 
ATOM   2691 C  C   . SER B 2 132 ? 21.210  61.069 103.335 1.00 19.63 ? 151 SER L C   1 
ATOM   2692 O  O   . SER B 2 132 ? 22.138  61.471 102.636 1.00 21.69 ? 151 SER L O   1 
ATOM   2693 C  CB  . SER B 2 132 ? 19.648  60.197 101.595 1.00 23.19 ? 151 SER L CB  1 
ATOM   2694 O  OG  . SER B 2 132 ? 18.337  60.251 101.024 1.00 25.55 ? 151 SER L OG  1 
ATOM   2695 N  N   . VAL B 2 133 ? 21.353  60.542 104.556 1.00 21.25 ? 152 VAL L N   1 
ATOM   2696 C  CA  . VAL B 2 133 ? 22.648  60.346 105.195 1.00 23.27 ? 152 VAL L CA  1 
ATOM   2697 C  C   . VAL B 2 133 ? 22.906  58.834 105.197 1.00 21.66 ? 152 VAL L C   1 
ATOM   2698 O  O   . VAL B 2 133 ? 22.032  58.075 105.613 1.00 21.11 ? 152 VAL L O   1 
ATOM   2699 C  CB  . VAL B 2 133 ? 22.661  60.893 106.638 1.00 22.78 ? 152 VAL L CB  1 
ATOM   2700 C  CG1 . VAL B 2 133 ? 24.075  60.951 107.212 1.00 23.57 ? 152 VAL L CG1 1 
ATOM   2701 C  CG2 . VAL B 2 133 ? 21.945  62.254 106.750 1.00 23.47 ? 152 VAL L CG2 1 
ATOM   2702 N  N   . VAL B 2 134 ? 24.067  58.403 104.728 1.00 21.16 ? 153 VAL L N   1 
ATOM   2703 C  CA  . VAL B 2 134 ? 24.331  56.979 104.557 1.00 20.06 ? 153 VAL L CA  1 
ATOM   2704 C  C   . VAL B 2 134 ? 25.440  56.569 105.518 1.00 19.50 ? 153 VAL L C   1 
ATOM   2705 O  O   . VAL B 2 134 ? 26.477  57.226 105.589 1.00 20.26 ? 153 VAL L O   1 
ATOM   2706 C  CB  . VAL B 2 134 ? 24.719  56.627 103.107 1.00 22.51 ? 153 VAL L CB  1 
ATOM   2707 C  CG1 . VAL B 2 134 ? 25.156  55.183 103.006 1.00 24.14 ? 153 VAL L CG1 1 
ATOM   2708 C  CG2 . VAL B 2 134 ? 23.579  56.897 102.129 1.00 24.88 ? 153 VAL L CG2 1 
ATOM   2709 N  N   . CYS B 2 135 ? 25.224  55.457 106.213 1.00 19.18 ? 154 CYS L N   1 
ATOM   2710 C  CA  . CYS B 2 135 ? 26.228  54.821 107.046 1.00 19.57 ? 154 CYS L CA  1 
ATOM   2711 C  C   . CYS B 2 135 ? 26.537  53.446 106.472 1.00 18.29 ? 154 CYS L C   1 
ATOM   2712 O  O   . CYS B 2 135 ? 25.625  52.648 106.218 1.00 21.94 ? 154 CYS L O   1 
ATOM   2713 C  CB  . CYS B 2 135 ? 25.680  54.670 108.452 1.00 19.93 ? 154 CYS L CB  1 
ATOM   2714 S  SG  . CYS B 2 135 ? 26.929  54.099 109.632 1.00 23.78 ? 154 CYS L SG  1 
ATOM   2715 N  N   . LEU B 2 136 ? 27.801  53.198 106.145 1.00 18.09 ? 155 LEU L N   1 
ATOM   2716 C  CA  . LEU B 2 136 ? 28.206  51.943 105.516 1.00 17.44 ? 155 LEU L CA  1 
ATOM   2717 C  C   . LEU B 2 136 ? 28.970  51.130 106.554 1.00 18.63 ? 155 LEU L C   1 
ATOM   2718 O  O   . LEU B 2 136 ? 29.916  51.629 107.195 1.00 17.84 ? 155 LEU L O   1 
ATOM   2719 C  CB  . LEU B 2 136 ? 29.142  52.206 104.333 1.00 18.70 ? 155 LEU L CB  1 
ATOM   2720 C  CG  . LEU B 2 136 ? 29.893  51.012 103.763 1.00 20.72 ? 155 LEU L CG  1 
ATOM   2721 C  CD1 . LEU B 2 136 ? 28.922  49.989 103.154 1.00 21.53 ? 155 LEU L CD1 1 
ATOM   2722 C  CD2 . LEU B 2 136 ? 30.863  51.492 102.693 1.00 23.15 ? 155 LEU L CD2 1 
ATOM   2723 N  N   . LEU B 2 137 ? 28.528  49.883 106.751 1.00 16.74 ? 156 LEU L N   1 
ATOM   2724 C  CA  . LEU B 2 137 ? 29.291  48.919 107.538 1.00 16.19 ? 156 LEU L CA  1 
ATOM   2725 C  C   . LEU B 2 137 ? 29.881  47.912 106.576 1.00 19.94 ? 156 LEU L C   1 
ATOM   2726 O  O   . LEU B 2 137 ? 29.139  47.128 105.961 1.00 19.11 ? 156 LEU L O   1 
ATOM   2727 C  CB  . LEU B 2 137 ? 28.377  48.187 108.531 1.00 18.20 ? 156 LEU L CB  1 
ATOM   2728 C  CG  . LEU B 2 137 ? 27.919  48.937 109.788 1.00 18.64 ? 156 LEU L CG  1 
ATOM   2729 C  CD1 . LEU B 2 137 ? 27.218  50.246 109.462 1.00 19.86 ? 156 LEU L CD1 1 
ATOM   2730 C  CD2 . LEU B 2 137 ? 27.034  48.006 110.652 1.00 20.82 ? 156 LEU L CD2 1 
ATOM   2731 N  N   . ASN B 2 138 ? 31.204  47.877 106.494 1.00 18.04 ? 157 ASN L N   1 
ATOM   2732 C  CA  . ASN B 2 138 ? 31.860  47.075 105.480 1.00 18.33 ? 157 ASN L CA  1 
ATOM   2733 C  C   . ASN B 2 138 ? 32.583  45.873 106.083 1.00 18.46 ? 157 ASN L C   1 
ATOM   2734 O  O   . ASN B 2 138 ? 33.387  45.954 107.015 1.00 18.92 ? 157 ASN L O   1 
ATOM   2735 C  CB  . ASN B 2 138 ? 32.816  47.961 104.660 1.00 20.28 ? 157 ASN L CB  1 
ATOM   2736 C  CG  . ASN B 2 138 ? 32.722  47.771 103.161 1.00 27.21 ? 157 ASN L CG  1 
ATOM   2737 O  OD1 . ASN B 2 138 ? 31.783  47.178 102.619 1.00 25.74 ? 157 ASN L OD1 1 
ATOM   2738 N  ND2 . ASN B 2 138 ? 33.705  48.317 102.464 1.00 29.74 ? 157 ASN L ND2 1 
ATOM   2739 N  N   . ASN B 2 139 ? 32.271  44.731 105.461 1.00 19.37 ? 158 ASN L N   1 
ATOM   2740 C  CA  . ASN B 2 139 ? 32.973  43.467 105.563 1.00 20.00 ? 158 ASN L CA  1 
ATOM   2741 C  C   . ASN B 2 139 ? 33.072  42.943 106.998 1.00 19.68 ? 158 ASN L C   1 
ATOM   2742 O  O   . ASN B 2 139 ? 34.152  42.914 107.600 1.00 21.39 ? 158 ASN L O   1 
ATOM   2743 C  CB  . ASN B 2 139 ? 34.322  43.572 104.853 1.00 23.99 ? 158 ASN L CB  1 
ATOM   2744 C  CG  . ASN B 2 139 ? 34.220  44.073 103.427 1.00 26.29 ? 158 ASN L CG  1 
ATOM   2745 O  OD1 . ASN B 2 139 ? 33.353  43.699 102.635 1.00 26.24 ? 158 ASN L OD1 1 
ATOM   2746 N  ND2 . ASN B 2 139 ? 35.090  45.002 103.063 1.00 28.45 ? 158 ASN L ND2 1 
ATOM   2747 N  N   . PHE B 2 140 ? 31.960  42.431 107.494 1.00 18.36 ? 159 PHE L N   1 
ATOM   2748 C  CA  . PHE B 2 140 ? 31.856  41.952 108.854 1.00 16.84 ? 159 PHE L CA  1 
ATOM   2749 C  C   . PHE B 2 140 ? 31.117  40.614 108.945 1.00 16.64 ? 159 PHE L C   1 
ATOM   2750 O  O   . PHE B 2 140 ? 30.462  40.157 107.996 1.00 17.55 ? 159 PHE L O   1 
ATOM   2751 C  CB  . PHE B 2 140 ? 31.119  43.008 109.695 1.00 16.29 ? 159 PHE L CB  1 
ATOM   2752 C  CG  . PHE B 2 140 ? 29.692  43.301 109.287 1.00 16.68 ? 159 PHE L CG  1 
ATOM   2753 C  CD1 . PHE B 2 140 ? 29.364  44.265 108.352 1.00 16.05 ? 159 PHE L CD1 1 
ATOM   2754 C  CD2 . PHE B 2 140 ? 28.651  42.594 109.861 1.00 17.00 ? 159 PHE L CD2 1 
ATOM   2755 C  CE1 . PHE B 2 140 ? 28.032  44.510 108.018 1.00 16.70 ? 159 PHE L CE1 1 
ATOM   2756 C  CE2 . PHE B 2 140 ? 27.325  42.813 109.511 1.00 16.85 ? 159 PHE L CE2 1 
ATOM   2757 C  CZ  . PHE B 2 140 ? 27.016  43.801 108.621 1.00 16.44 ? 159 PHE L CZ  1 
ATOM   2758 N  N   . TYR B 2 141 ? 31.197  40.012 110.120 1.00 15.81 ? 160 TYR L N   1 
ATOM   2759 C  CA  . TYR B 2 141 ? 30.501  38.770 110.414 1.00 16.77 ? 160 TYR L CA  1 
ATOM   2760 C  C   . TYR B 2 141 ? 30.452  38.620 111.911 1.00 17.99 ? 160 TYR L C   1 
ATOM   2761 O  O   . TYR B 2 141 ? 31.472  38.839 112.582 1.00 18.64 ? 160 TYR L O   1 
ATOM   2762 C  CB  . TYR B 2 141 ? 31.223  37.566 109.768 1.00 16.93 ? 160 TYR L CB  1 
ATOM   2763 C  CG  . TYR B 2 141 ? 30.494  36.273 110.046 1.00 16.17 ? 160 TYR L CG  1 
ATOM   2764 C  CD1 . TYR B 2 141 ? 30.571  35.605 111.250 1.00 16.69 ? 160 TYR L CD1 1 
ATOM   2765 C  CD2 . TYR B 2 141 ? 29.583  35.812 109.112 1.00 18.36 ? 160 TYR L CD2 1 
ATOM   2766 C  CE1 . TYR B 2 141 ? 29.786  34.518 111.557 1.00 18.81 ? 160 TYR L CE1 1 
ATOM   2767 C  CE2 . TYR B 2 141 ? 28.783  34.713 109.402 1.00 19.10 ? 160 TYR L CE2 1 
ATOM   2768 C  CZ  . TYR B 2 141 ? 28.904  34.053 110.597 1.00 19.10 ? 160 TYR L CZ  1 
ATOM   2769 O  OH  . TYR B 2 141 ? 28.087  33.003 110.953 1.00 21.42 ? 160 TYR L OH  1 
ATOM   2770 N  N   . PRO B 2 142 ? 29.339  38.233 112.561 1.00 16.88 ? 161 PRO L N   1 
ATOM   2771 C  CA  . PRO B 2 142 ? 28.112  37.784 111.898 1.00 16.61 ? 161 PRO L CA  1 
ATOM   2772 C  C   . PRO B 2 142 ? 27.263  38.900 111.316 1.00 16.17 ? 161 PRO L C   1 
ATOM   2773 O  O   . PRO B 2 142 ? 27.593  40.061 111.444 1.00 16.43 ? 161 PRO L O   1 
ATOM   2774 C  CB  . PRO B 2 142 ? 27.362  37.101 113.048 1.00 17.80 ? 161 PRO L CB  1 
ATOM   2775 C  CG  . PRO B 2 142 ? 27.806  37.819 114.270 1.00 21.59 ? 161 PRO L CG  1 
ATOM   2776 C  CD  . PRO B 2 142 ? 29.268  38.103 114.019 1.00 18.31 ? 161 PRO L CD  1 
ATOM   2777 N  N   . ARG B 2 143 ? 26.157  38.496 110.678 1.00 18.64 ? 162 ARG L N   1 
ATOM   2778 C  CA  . ARG B 2 143 ? 25.286  39.411 109.953 1.00 18.93 ? 162 ARG L CA  1 
ATOM   2779 C  C   . ARG B 2 143 ? 24.612  40.400 110.916 1.00 18.69 ? 162 ARG L C   1 
ATOM   2780 O  O   . ARG B 2 143 ? 24.302  41.525 110.538 1.00 20.21 ? 162 ARG L O   1 
ATOM   2781 C  CB  . ARG B 2 143 ? 24.202  38.594 109.251 1.00 20.49 ? 162 ARG L CB  1 
ATOM   2782 C  CG  . ARG B 2 143 ? 23.397  39.406 108.237 1.00 24.76 ? 162 ARG L CG  1 
ATOM   2783 C  CD  . ARG B 2 143 ? 22.473  38.422 107.515 1.00 29.16 ? 162 ARG L CD  1 
ATOM   2784 N  NE  . ARG B 2 143 ? 21.663  39.039 106.455 1.00 32.92 ? 162 ARG L NE  1 
ATOM   2785 C  CZ  . ARG B 2 143 ? 20.544  39.734 106.631 1.00 29.70 ? 162 ARG L CZ  1 
ATOM   2786 N  NH1 . ARG B 2 143 ? 20.064  39.993 107.826 1.00 30.97 ? 162 ARG L NH1 1 
ATOM   2787 N  NH2 . ARG B 2 143 ? 19.919  40.232 105.578 1.00 36.22 ? 162 ARG L NH2 1 
ATOM   2788 N  N   . GLU B 2 144 ? 24.339  39.961 112.137 1.00 18.73 ? 163 GLU L N   1 
ATOM   2789 C  CA  . GLU B 2 144 ? 23.609  40.770 113.110 1.00 21.22 ? 163 GLU L CA  1 
ATOM   2790 C  C   . GLU B 2 144 ? 24.467  41.968 113.535 1.00 21.34 ? 163 GLU L C   1 
ATOM   2791 O  O   . GLU B 2 144 ? 25.617  41.822 113.905 1.00 21.27 ? 163 GLU L O   1 
ATOM   2792 C  CB  . GLU B 2 144 ? 23.271  39.937 114.357 1.00 26.36 ? 163 GLU L CB  1 
ATOM   2793 C  CG  . GLU B 2 144 ? 22.295  38.783 114.098 1.00 35.30 ? 163 GLU L CG  1 
ATOM   2794 C  CD  . GLU B 2 144 ? 22.647  37.666 113.117 1.00 38.78 ? 163 GLU L CD  1 
ATOM   2795 O  OE1 . GLU B 2 144 ? 21.723  37.231 112.339 1.00 42.24 ? 163 GLU L OE1 1 
ATOM   2796 O  OE2 . GLU B 2 144 ? 23.851  37.262 113.055 1.00 31.79 ? 163 GLU L OE2 1 
ATOM   2797 N  N   . ALA B 2 145 ? 23.886  43.156 113.425 1.00 25.06 ? 164 ALA L N   1 
ATOM   2798 C  CA  . ALA B 2 145 ? 24.531  44.394 113.808 1.00 22.88 ? 164 ALA L CA  1 
ATOM   2799 C  C   . ALA B 2 145 ? 23.443  45.374 114.189 1.00 27.46 ? 164 ALA L C   1 
ATOM   2800 O  O   . ALA B 2 145 ? 22.341  45.332 113.637 1.00 26.09 ? 164 ALA L O   1 
ATOM   2801 C  CB  . ALA B 2 145 ? 25.321  44.937 112.659 1.00 23.42 ? 164 ALA L CB  1 
ATOM   2802 N  N   . LYS B 2 146 ? 23.802  46.299 115.048 1.00 21.66 ? 165 LYS L N   1 
ATOM   2803 C  CA  . LYS B 2 146 ? 22.853  47.333 115.423 1.00 24.86 ? 165 LYS L CA  1 
ATOM   2804 C  C   . LYS B 2 146 ? 23.416  48.678 114.990 1.00 25.66 ? 165 LYS L C   1 
ATOM   2805 O  O   . LYS B 2 146 ? 24.551  49.026 115.319 1.00 23.56 ? 165 LYS L O   1 
ATOM   2806 C  CB  . LYS B 2 146 ? 22.584  47.313 116.923 1.00 29.52 ? 165 LYS L CB  1 
ATOM   2807 C  CG  . LYS B 2 146 ? 21.822  48.542 117.406 1.00 39.43 ? 165 LYS L CG  1 
ATOM   2808 C  CD  . LYS B 2 146 ? 21.155  48.421 118.766 1.00 49.87 ? 165 LYS L CD  1 
ATOM   2809 C  CE  . LYS B 2 146 ? 22.122  48.459 119.925 1.00 53.87 ? 165 LYS L CE  1 
ATOM   2810 N  NZ  . LYS B 2 146 ? 21.431  48.908 121.156 1.00 59.77 ? 165 LYS L NZ  1 
ATOM   2811 N  N   . VAL B 2 147 ? 22.639  49.417 114.198 1.00 20.79 ? 166 VAL L N   1 
ATOM   2812 C  CA  . VAL B 2 147 ? 22.978  50.761 113.811 1.00 22.46 ? 166 VAL L CA  1 
ATOM   2813 C  C   . VAL B 2 147 ? 22.016  51.718 114.483 1.00 22.58 ? 166 VAL L C   1 
ATOM   2814 O  O   . VAL B 2 147 ? 20.794  51.607 114.277 1.00 25.73 ? 166 VAL L O   1 
ATOM   2815 C  CB  . VAL B 2 147 ? 22.917  50.963 112.288 1.00 28.41 ? 166 VAL L CB  1 
ATOM   2816 C  CG1 . VAL B 2 147 ? 23.245  52.400 111.937 1.00 31.71 ? 166 VAL L CG1 1 
ATOM   2817 C  CG2 . VAL B 2 147 ? 23.839  49.990 111.584 1.00 30.02 ? 166 VAL L CG2 1 
ATOM   2818 N  N   . GLN B 2 148 ? 22.549  52.674 115.236 1.00 21.30 ? 167 GLN L N   1 
ATOM   2819 C  CA  . GLN B 2 148 ? 21.724  53.704 115.842 1.00 21.65 ? 167 GLN L CA  1 
ATOM   2820 C  C   . GLN B 2 148 ? 22.158  55.049 115.292 1.00 22.74 ? 167 GLN L C   1 
ATOM   2821 O  O   . GLN B 2 148 ? 23.292  55.477 115.487 1.00 23.66 ? 167 GLN L O   1 
ATOM   2822 C  CB  . GLN B 2 148 ? 21.871  53.707 117.363 1.00 27.82 ? 167 GLN L CB  1 
ATOM   2823 C  CG  . GLN B 2 148 ? 21.381  52.411 117.987 1.00 36.88 ? 167 GLN L CG  1 
ATOM   2824 C  CD  . GLN B 2 148 ? 21.469  52.411 119.496 1.00 50.14 ? 167 GLN L CD  1 
ATOM   2825 O  OE1 . GLN B 2 148 ? 20.457  52.481 120.192 1.00 49.66 ? 167 GLN L OE1 1 
ATOM   2826 N  NE2 . GLN B 2 148 ? 22.684  52.295 120.011 1.00 57.20 ? 167 GLN L NE2 1 
ATOM   2827 N  N   . TRP B 2 149 ? 21.193  55.765 114.711 1.00 21.35 ? 168 TRP L N   1 
ATOM   2828 C  CA  . TRP B 2 149 ? 21.409  57.130 114.297 1.00 18.62 ? 168 TRP L CA  1 
ATOM   2829 C  C   . TRP B 2 149 ? 21.157  58.099 115.461 1.00 19.95 ? 168 TRP L C   1 
ATOM   2830 O  O   . TRP B 2 149 ? 20.172  57.955 116.174 1.00 21.82 ? 168 TRP L O   1 
ATOM   2831 C  CB  . TRP B 2 149 ? 20.476  57.483 113.138 1.00 19.49 ? 168 TRP L CB  1 
ATOM   2832 C  CG  . TRP B 2 149 ? 20.857  56.840 111.848 1.00 19.18 ? 168 TRP L CG  1 
ATOM   2833 C  CD1 . TRP B 2 149 ? 20.347  55.715 111.285 1.00 18.40 ? 168 TRP L CD1 1 
ATOM   2834 C  CD2 . TRP B 2 149 ? 21.855  57.329 110.956 1.00 20.33 ? 168 TRP L CD2 1 
ATOM   2835 N  NE1 . TRP B 2 149 ? 20.949  55.484 110.086 1.00 21.20 ? 168 TRP L NE1 1 
ATOM   2836 C  CE2 . TRP B 2 149 ? 21.885  56.448 109.854 1.00 19.91 ? 168 TRP L CE2 1 
ATOM   2837 C  CE3 . TRP B 2 149 ? 22.739  58.412 111.000 1.00 20.04 ? 168 TRP L CE3 1 
ATOM   2838 C  CZ2 . TRP B 2 149 ? 22.742  56.647 108.768 1.00 20.50 ? 168 TRP L CZ2 1 
ATOM   2839 C  CZ3 . TRP B 2 149 ? 23.585  58.596 109.937 1.00 19.97 ? 168 TRP L CZ3 1 
ATOM   2840 C  CH2 . TRP B 2 149 ? 23.584  57.726 108.844 1.00 21.55 ? 168 TRP L CH2 1 
ATOM   2841 N  N   . LYS B 2 150 ? 22.046  59.077 115.607 1.00 20.11 ? 169 LYS L N   1 
ATOM   2842 C  CA  . LYS B 2 150 ? 21.867  60.151 116.572 1.00 25.69 ? 169 LYS L CA  1 
ATOM   2843 C  C   . LYS B 2 150 ? 22.012  61.489 115.867 1.00 24.91 ? 169 LYS L C   1 
ATOM   2844 O  O   . LYS B 2 150 ? 22.893  61.723 115.055 1.00 24.73 ? 169 LYS L O   1 
ATOM   2845 C  CB  . LYS B 2 150 ? 22.867  60.071 117.727 1.00 24.79 ? 169 LYS L CB  1 
ATOM   2846 C  CG  . LYS B 2 150 ? 22.754  58.768 118.516 1.00 30.69 ? 169 LYS L CG  1 
ATOM   2847 C  CD  . LYS B 2 150 ? 23.836  58.584 119.565 1.00 32.67 ? 169 LYS L CD  1 
ATOM   2848 C  CE  . LYS B 2 150 ? 23.802  57.183 120.126 1.00 37.93 ? 169 LYS L CE  1 
ATOM   2849 N  NZ  . LYS B 2 150 ? 24.811  57.001 121.198 1.00 42.91 ? 169 LYS L NZ  1 
ATOM   2850 N  N   . VAL B 2 151 ? 21.086  62.392 116.185 1.00 24.27 ? 170 VAL L N   1 
ATOM   2851 C  CA  . VAL B 2 151 ? 21.138  63.720 115.630 1.00 23.79 ? 170 VAL L CA  1 
ATOM   2852 C  C   . VAL B 2 151 ? 21.200  64.689 116.799 1.00 26.70 ? 170 VAL L C   1 
ATOM   2853 O  O   . VAL B 2 151 ? 20.287  64.703 117.620 1.00 25.23 ? 170 VAL L O   1 
ATOM   2854 C  CB  . VAL B 2 151 ? 19.923  63.988 114.719 1.00 26.34 ? 170 VAL L CB  1 
ATOM   2855 C  CG1 . VAL B 2 151 ? 19.976  65.388 114.141 1.00 25.57 ? 170 VAL L CG1 1 
ATOM   2856 C  CG2 . VAL B 2 151 ? 19.789  62.962 113.595 1.00 26.94 ? 170 VAL L CG2 1 
ATOM   2857 N  N   . ASP B 2 152 ? 22.312  65.428 116.889 1.00 26.66 ? 171 ASP L N   1 
ATOM   2858 C  CA  . ASP B 2 152 ? 22.610  66.239 118.074 1.00 27.04 ? 171 ASP L CA  1 
ATOM   2859 C  C   . ASP B 2 152 ? 22.386  65.432 119.347 1.00 31.45 ? 171 ASP L C   1 
ATOM   2860 O  O   . ASP B 2 152 ? 21.800  65.916 120.319 1.00 31.24 ? 171 ASP L O   1 
ATOM   2861 C  CB  . ASP B 2 152 ? 21.805  67.544 118.051 1.00 28.69 ? 171 ASP L CB  1 
ATOM   2862 C  CG  . ASP B 2 152 ? 22.242  68.523 116.972 1.00 27.05 ? 171 ASP L CG  1 
ATOM   2863 O  OD1 . ASP B 2 152 ? 23.435  68.591 116.659 1.00 29.26 ? 171 ASP L OD1 1 
ATOM   2864 O  OD2 . ASP B 2 152 ? 21.393  69.329 116.556 1.00 30.34 ? 171 ASP L OD2 1 
ATOM   2865 N  N   . ASN B 2 153 ? 22.840  64.174 119.296 1.00 28.96 ? 172 ASN L N   1 
ATOM   2866 C  CA  . ASN B 2 153 ? 22.850  63.224 120.387 1.00 30.34 ? 172 ASN L CA  1 
ATOM   2867 C  C   . ASN B 2 153 ? 21.450  62.696 120.724 1.00 29.54 ? 172 ASN L C   1 
ATOM   2868 O  O   . ASN B 2 153 ? 21.301  61.956 121.688 1.00 34.13 ? 172 ASN L O   1 
ATOM   2869 C  CB  . ASN B 2 153 ? 23.579  63.798 121.605 1.00 34.71 ? 172 ASN L CB  1 
ATOM   2870 C  CG  . ASN B 2 153 ? 24.105  62.693 122.493 1.00 46.84 ? 172 ASN L CG  1 
ATOM   2871 O  OD1 . ASN B 2 153 ? 24.686  61.710 122.019 1.00 44.19 ? 172 ASN L OD1 1 
ATOM   2872 N  ND2 . ASN B 2 153 ? 23.845  62.818 123.782 1.00 47.90 ? 172 ASN L ND2 1 
ATOM   2873 N  N   . ALA B 2 154 ? 20.424  63.001 119.926 1.00 29.38 ? 173 ALA L N   1 
ATOM   2874 C  CA  . ALA B 2 154 ? 19.110  62.437 120.165 1.00 31.33 ? 173 ALA L CA  1 
ATOM   2875 C  C   . ALA B 2 154 ? 18.935  61.180 119.319 1.00 27.86 ? 173 ALA L C   1 
ATOM   2876 O  O   . ALA B 2 154 ? 19.123  61.236 118.099 1.00 27.73 ? 173 ALA L O   1 
ATOM   2877 C  CB  . ALA B 2 154 ? 18.061  63.457 119.811 1.00 31.33 ? 173 ALA L CB  1 
ATOM   2878 N  N   . LEU B 2 155 ? 18.513  60.087 119.970 1.00 29.27 ? 174 LEU L N   1 
ATOM   2879 C  CA  . LEU B 2 155 ? 18.300  58.816 119.297 1.00 30.11 ? 174 LEU L CA  1 
ATOM   2880 C  C   . LEU B 2 155 ? 17.169  58.954 118.299 1.00 28.29 ? 174 LEU L C   1 
ATOM   2881 O  O   . LEU B 2 155 ? 16.123  59.461 118.646 1.00 30.56 ? 174 LEU L O   1 
ATOM   2882 C  CB  . LEU B 2 155 ? 17.926  57.721 120.302 1.00 33.09 ? 174 LEU L CB  1 
ATOM   2883 C  CG  . LEU B 2 155 ? 18.949  56.614 120.490 1.00 43.17 ? 174 LEU L CG  1 
ATOM   2884 C  CD1 . LEU B 2 155 ? 19.265  55.970 119.146 1.00 45.81 ? 174 LEU L CD1 1 
ATOM   2885 C  CD2 . LEU B 2 155 ? 20.193  57.158 121.174 1.00 41.61 ? 174 LEU L CD2 1 
ATOM   2886 N  N   . GLN B 2 156 ? 17.387  58.486 117.075 1.00 27.47 ? 175 GLN L N   1 
ATOM   2887 C  CA  . GLN B 2 156 ? 16.396  58.498 116.010 1.00 26.11 ? 175 GLN L CA  1 
ATOM   2888 C  C   . GLN B 2 156 ? 15.674  57.167 115.979 1.00 27.98 ? 175 GLN L C   1 
ATOM   2889 O  O   . GLN B 2 156 ? 16.222  56.147 116.372 1.00 29.61 ? 175 GLN L O   1 
ATOM   2890 C  CB  . GLN B 2 156 ? 17.033  58.720 114.648 1.00 28.90 ? 175 GLN L CB  1 
ATOM   2891 C  CG  . GLN B 2 156 ? 17.838  59.994 114.557 1.00 24.17 ? 175 GLN L CG  1 
ATOM   2892 C  CD  . GLN B 2 156 ? 16.959  61.209 114.729 1.00 29.83 ? 175 GLN L CD  1 
ATOM   2893 O  OE1 . GLN B 2 156 ? 16.151  61.566 113.856 1.00 28.28 ? 175 GLN L OE1 1 
ATOM   2894 N  NE2 . GLN B 2 156 ? 17.129  61.841 115.871 1.00 27.61 ? 175 GLN L NE2 1 
ATOM   2895 N  N   . SER B 2 157 ? 14.418  57.204 115.558 1.00 31.71 ? 176 SER L N   1 
ATOM   2896 C  CA  . SER B 2 157 ? 13.680  55.989 115.270 1.00 34.03 ? 176 SER L CA  1 
ATOM   2897 C  C   . SER B 2 157 ? 12.663  56.283 114.182 1.00 29.78 ? 176 SER L C   1 
ATOM   2898 O  O   . SER B 2 157 ? 12.194  57.414 114.048 1.00 33.93 ? 176 SER L O   1 
ATOM   2899 C  CB  . SER B 2 157 ? 13.067  55.375 116.507 1.00 40.95 ? 176 SER L CB  1 
ATOM   2900 O  OG  . SER B 2 157 ? 12.235  56.298 117.162 1.00 43.06 ? 176 SER L OG  1 
ATOM   2901 N  N   . GLY B 2 158 ? 12.458  55.284 113.325 1.00 31.02 ? 177 GLY L N   1 
ATOM   2902 C  CA  . GLY B 2 158 ? 11.424  55.315 112.310 1.00 30.74 ? 177 GLY L CA  1 
ATOM   2903 C  C   . GLY B 2 158 ? 11.817  56.010 111.011 1.00 36.03 ? 177 GLY L C   1 
ATOM   2904 O  O   . GLY B 2 158 ? 11.033  55.992 110.063 1.00 33.00 ? 177 GLY L O   1 
ATOM   2905 N  N   . ASN B 2 159 ? 13.019  56.598 110.925 1.00 24.97 ? 178 ASN L N   1 
ATOM   2906 C  CA  . ASN B 2 159 ? 13.393  57.385 109.762 1.00 27.38 ? 178 ASN L CA  1 
ATOM   2907 C  C   . ASN B 2 159 ? 14.656  56.825 109.101 1.00 24.35 ? 178 ASN L C   1 
ATOM   2908 O  O   . ASN B 2 159 ? 15.327  57.536 108.346 1.00 26.40 ? 178 ASN L O   1 
ATOM   2909 C  CB  . ASN B 2 159 ? 13.602  58.860 110.113 1.00 29.04 ? 178 ASN L CB  1 
ATOM   2910 C  CG  . ASN B 2 159 ? 14.494  59.066 111.312 1.00 27.86 ? 178 ASN L CG  1 
ATOM   2911 O  OD1 . ASN B 2 159 ? 15.034  58.111 111.865 1.00 29.79 ? 178 ASN L OD1 1 
ATOM   2912 N  ND2 . ASN B 2 159 ? 14.595  60.314 111.767 1.00 30.99 ? 178 ASN L ND2 1 
ATOM   2913 N  N   . SER B 2 160 ? 14.941  55.544 109.364 1.00 24.44 ? 179 SER L N   1 
ATOM   2914 C  CA  . SER B 2 160 ? 16.014  54.838 108.667 1.00 23.15 ? 179 SER L CA  1 
ATOM   2915 C  C   . SER B 2 160 ? 15.591  53.489 108.081 1.00 21.68 ? 179 SER L C   1 
ATOM   2916 O  O   . SER B 2 160 ? 14.702  52.808 108.570 1.00 26.46 ? 179 SER L O   1 
ATOM   2917 C  CB  . SER B 2 160 ? 17.189  54.667 109.579 1.00 22.42 ? 179 SER L CB  1 
ATOM   2918 O  OG  . SER B 2 160 ? 16.835  53.974 110.735 1.00 24.60 ? 179 SER L OG  1 
ATOM   2919 N  N   . GLN B 2 161 ? 16.341  53.071 107.076 1.00 24.46 ? 180 GLN L N   1 
ATOM   2920 C  CA  . GLN B 2 161 ? 16.195  51.743 106.509 1.00 23.37 ? 180 GLN L CA  1 
ATOM   2921 C  C   . GLN B 2 161 ? 17.570  51.145 106.229 1.00 23.20 ? 180 GLN L C   1 
ATOM   2922 O  O   . GLN B 2 161 ? 18.511  51.849 105.872 1.00 21.86 ? 180 GLN L O   1 
ATOM   2923 C  CB  . GLN B 2 161 ? 15.364  51.805 105.223 1.00 25.68 ? 180 GLN L CB  1 
ATOM   2924 C  CG  . GLN B 2 161 ? 13.936  52.318 105.431 1.00 25.97 ? 180 GLN L CG  1 
ATOM   2925 C  CD  . GLN B 2 161 ? 13.160  52.251 104.123 1.00 31.54 ? 180 GLN L CD  1 
ATOM   2926 O  OE1 . GLN B 2 161 ? 13.316  53.062 103.223 1.00 34.11 ? 180 GLN L OE1 1 
ATOM   2927 N  NE2 . GLN B 2 161 ? 12.321  51.242 103.977 1.00 30.13 ? 180 GLN L NE2 1 
ATOM   2928 N  N   . GLU B 2 162 ? 17.651  49.812 106.329 1.00 23.49 ? 181 GLU L N   1 
ATOM   2929 C  CA  . GLU B 2 162 ? 18.893  49.066 106.166 1.00 23.71 ? 181 GLU L CA  1 
ATOM   2930 C  C   . GLU B 2 162 ? 18.725  48.001 105.103 1.00 23.26 ? 181 GLU L C   1 
ATOM   2931 O  O   . GLU B 2 162 ? 17.630  47.461 104.921 1.00 23.32 ? 181 GLU L O   1 
ATOM   2932 C  CB  . GLU B 2 162 ? 19.225  48.195 107.382 1.00 27.92 ? 181 GLU L CB  1 
ATOM   2933 C  CG  . GLU B 2 162 ? 19.519  48.957 108.596 1.00 32.29 ? 181 GLU L CG  1 
ATOM   2934 C  CD  . GLU B 2 162 ? 19.850  48.095 109.783 1.00 28.47 ? 181 GLU L CD  1 
ATOM   2935 O  OE1 . GLU B 2 162 ? 19.662  46.836 109.751 1.00 29.17 ? 181 GLU L OE1 1 
ATOM   2936 O  OE2 . GLU B 2 162 ? 20.202  48.697 110.786 1.00 38.07 ? 181 GLU L OE2 1 
ATOM   2937 N  N   . SER B 2 163 ? 19.848  47.677 104.475 1.00 21.36 ? 182 SER L N   1 
ATOM   2938 C  CA  . SER B 2 163 ? 19.953  46.636 103.480 1.00 20.57 ? 182 SER L CA  1 
ATOM   2939 C  C   . SER B 2 163 ? 21.295  45.941 103.692 1.00 21.11 ? 182 SER L C   1 
ATOM   2940 O  O   . SER B 2 163 ? 22.259  46.613 104.071 1.00 19.46 ? 182 SER L O   1 
ATOM   2941 C  CB  . SER B 2 163 ? 19.831  47.325 102.107 1.00 22.95 ? 182 SER L CB  1 
ATOM   2942 O  OG  . SER B 2 163 ? 20.066  46.481 101.073 1.00 29.05 ? 182 SER L OG  1 
ATOM   2943 N  N   . VAL B 2 164 ? 21.374  44.629 103.423 1.00 20.95 ? 183 VAL L N   1 
ATOM   2944 C  CA  . VAL B 2 164 ? 22.561  43.812 103.624 1.00 21.13 ? 183 VAL L CA  1 
ATOM   2945 C  C   . VAL B 2 164 ? 22.897  43.056 102.336 1.00 17.98 ? 183 VAL L C   1 
ATOM   2946 O  O   . VAL B 2 164 ? 22.031  42.452 101.723 1.00 22.02 ? 183 VAL L O   1 
ATOM   2947 C  CB  . VAL B 2 164 ? 22.335  42.834 104.791 1.00 21.21 ? 183 VAL L CB  1 
ATOM   2948 C  CG1 . VAL B 2 164 ? 23.611  42.088 105.153 1.00 20.88 ? 183 VAL L CG1 1 
ATOM   2949 C  CG2 . VAL B 2 164 ? 21.761  43.545 106.006 1.00 23.95 ? 183 VAL L CG2 1 
ATOM   2950 N  N   . THR B 2 165 ? 24.156  43.037 101.971 1.00 18.13 ? 184 THR L N   1 
ATOM   2951 C  CA  . THR B 2 165 ? 24.634  42.287 100.813 1.00 18.38 ? 184 THR L CA  1 
ATOM   2952 C  C   . THR B 2 165 ? 24.568  40.788 101.072 1.00 18.81 ? 184 THR L C   1 
ATOM   2953 O  O   . THR B 2 165 ? 24.491  40.336 102.217 1.00 21.99 ? 184 THR L O   1 
ATOM   2954 C  CB  . THR B 2 165 ? 26.072  42.650 100.424 1.00 22.60 ? 184 THR L CB  1 
ATOM   2955 O  OG1 . THR B 2 165 ? 26.957  42.430 101.531 1.00 24.93 ? 184 THR L OG1 1 
ATOM   2956 C  CG2 . THR B 2 165 ? 26.222  44.072 99.916  1.00 25.03 ? 184 THR L CG2 1 
ATOM   2957 N  N   . GLU B 2 166 ? 24.641  40.045 99.958  1.00 21.86 ? 185 GLU L N   1 
ATOM   2958 C  CA  . GLU B 2 166 ? 24.848  38.614 100.082 1.00 23.95 ? 185 GLU L CA  1 
ATOM   2959 C  C   . GLU B 2 166 ? 26.237  38.372 100.668 1.00 22.28 ? 185 GLU L C   1 
ATOM   2960 O  O   . GLU B 2 166 ? 27.140  39.172 100.518 1.00 22.23 ? 185 GLU L O   1 
ATOM   2961 C  CB  . GLU B 2 166 ? 24.659  37.877 98.756  1.00 29.97 ? 185 GLU L CB  1 
ATOM   2962 C  CG  . GLU B 2 166 ? 25.722  38.073 97.695  1.00 37.37 ? 185 GLU L CG  1 
ATOM   2963 C  CD  . GLU B 2 166 ? 25.608  37.105 96.511  1.00 43.68 ? 185 GLU L CD  1 
ATOM   2964 O  OE1 . GLU B 2 166 ? 24.490  36.709 96.176  1.00 53.11 ? 185 GLU L OE1 1 
ATOM   2965 O  OE2 . GLU B 2 166 ? 26.638  36.754 95.913  1.00 47.65 ? 185 GLU L OE2 1 
ATOM   2966 N  N   . GLN B 2 167 ? 26.410  37.217 101.315 1.00 19.38 ? 186 GLN L N   1 
ATOM   2967 C  CA  . GLN B 2 167 ? 27.713  36.812 101.806 1.00 19.94 ? 186 GLN L CA  1 
ATOM   2968 C  C   . GLN B 2 167 ? 28.775  36.810 100.701 1.00 17.14 ? 186 GLN L C   1 
ATOM   2969 O  O   . GLN B 2 167 ? 28.497  36.398 99.556  1.00 19.45 ? 186 GLN L O   1 
ATOM   2970 C  CB  . GLN B 2 167 ? 27.488  35.427 102.398 1.00 20.79 ? 186 GLN L CB  1 
ATOM   2971 C  CG  . GLN B 2 167 ? 28.549  35.014 103.318 1.00 23.96 ? 186 GLN L CG  1 
ATOM   2972 C  CD  . GLN B 2 167 ? 28.049  33.998 104.327 1.00 20.80 ? 186 GLN L CD  1 
ATOM   2973 O  OE1 . GLN B 2 167 ? 27.168  33.142 104.110 1.00 19.53 ? 186 GLN L OE1 1 
ATOM   2974 N  NE2 . GLN B 2 167 ? 28.744  34.033 105.433 1.00 18.14 ? 186 GLN L NE2 1 
ATOM   2975 N  N   . ASP B 2 168 ? 29.978  37.261 101.035 1.00 17.57 ? 187 ASP L N   1 
ATOM   2976 C  CA  . ASP B 2 168 ? 31.117  37.206 100.132 1.00 19.08 ? 187 ASP L CA  1 
ATOM   2977 C  C   . ASP B 2 168 ? 31.472  35.741 99.909  1.00 19.63 ? 187 ASP L C   1 
ATOM   2978 O  O   . ASP B 2 168 ? 31.566  34.953 100.873 1.00 19.35 ? 187 ASP L O   1 
ATOM   2979 C  CB  . ASP B 2 168 ? 32.283  37.989 100.729 1.00 22.20 ? 187 ASP L CB  1 
ATOM   2980 C  CG  . ASP B 2 168 ? 33.477  38.159 99.805  1.00 26.55 ? 187 ASP L CG  1 
ATOM   2981 O  OD1 . ASP B 2 168 ? 34.244  37.209 99.632  1.00 23.83 ? 187 ASP L OD1 1 
ATOM   2982 O  OD2 . ASP B 2 168 ? 33.638  39.290 99.316  1.00 27.79 ? 187 ASP L OD2 1 
ATOM   2983 N  N   . SER B 2 169 ? 31.682  35.355 98.652  1.00 22.54 ? 188 SER L N   1 
ATOM   2984 C  CA  . SER B 2 169 ? 31.905  33.952 98.350  1.00 22.32 ? 188 SER L CA  1 
ATOM   2985 C  C   . SER B 2 169 ? 33.304  33.479 98.720  1.00 25.02 ? 188 SER L C   1 
ATOM   2986 O  O   . SER B 2 169 ? 33.571  32.283 98.663  1.00 24.38 ? 188 SER L O   1 
ATOM   2987 C  CB  . SER B 2 169 ? 31.550  33.677 96.913  1.00 28.61 ? 188 SER L CB  1 
ATOM   2988 O  OG  . SER B 2 169 ? 32.460  34.355 96.065  1.00 33.86 ? 188 SER L OG  1 
ATOM   2989 N  N   . LYS B 2 170 ? 34.228  34.396 99.046  1.00 22.22 ? 189 LYS L N   1 
ATOM   2990 C  CA  . LYS B 2 170 ? 35.581  33.989 99.402  1.00 23.43 ? 189 LYS L CA  1 
ATOM   2991 C  C   . LYS B 2 170 ? 35.830  34.165 100.898 1.00 22.86 ? 189 LYS L C   1 
ATOM   2992 O  O   . LYS B 2 170 ? 36.430  33.286 101.510 1.00 25.47 ? 189 LYS L O   1 
ATOM   2993 C  CB  . LYS B 2 170 ? 36.598  34.746 98.546  1.00 29.71 ? 189 LYS L CB  1 
ATOM   2994 C  CG  . LYS B 2 170 ? 36.510  34.413 97.061  1.00 37.46 ? 189 LYS L CG  1 
ATOM   2995 C  CD  . LYS B 2 170 ? 37.482  35.218 96.209  1.00 46.06 ? 189 LYS L CD  1 
ATOM   2996 C  CE  . LYS B 2 170 ? 38.924  34.810 96.426  1.00 56.23 ? 189 LYS L CE  1 
ATOM   2997 N  NZ  . LYS B 2 170 ? 39.732  35.016 95.198  1.00 66.46 ? 189 LYS L NZ  1 
ATOM   2998 N  N   . ASP B 2 171 ? 35.399  35.293 101.497 1.00 21.25 ? 190 ASP L N   1 
ATOM   2999 C  CA  . ASP B 2 171 ? 35.775  35.544 102.880 1.00 22.39 ? 190 ASP L CA  1 
ATOM   3000 C  C   . ASP B 2 171 ? 34.568  35.521 103.817 1.00 18.89 ? 190 ASP L C   1 
ATOM   3001 O  O   . ASP B 2 171 ? 34.733  35.709 105.002 1.00 20.25 ? 190 ASP L O   1 
ATOM   3002 C  CB  . ASP B 2 171 ? 36.535  36.869 103.053 1.00 25.04 ? 190 ASP L CB  1 
ATOM   3003 C  CG  . ASP B 2 171 ? 35.733  38.141 102.915 1.00 27.57 ? 190 ASP L CG  1 
ATOM   3004 O  OD1 . ASP B 2 171 ? 34.500  38.078 102.907 1.00 24.07 ? 190 ASP L OD1 1 
ATOM   3005 O  OD2 . ASP B 2 171 ? 36.379  39.210 102.712 1.00 31.02 ? 190 ASP L OD2 1 
ATOM   3006 N  N   . SER B 2 172 ? 33.363  35.250 103.304 1.00 17.58 ? 191 SER L N   1 
ATOM   3007 C  CA  . SER B 2 172 ? 32.167  34.967 104.096 1.00 18.17 ? 191 SER L CA  1 
ATOM   3008 C  C   . SER B 2 172 ? 31.654  36.153 104.921 1.00 19.91 ? 191 SER L C   1 
ATOM   3009 O  O   . SER B 2 172 ? 30.804  35.976 105.805 1.00 18.72 ? 191 SER L O   1 
ATOM   3010 C  CB  . SER B 2 172 ? 32.363  33.734 104.962 1.00 19.25 ? 191 SER L CB  1 
ATOM   3011 O  OG  . SER B 2 172 ? 32.775  32.618 104.160 1.00 19.69 ? 191 SER L OG  1 
ATOM   3012 N  N   . THR B 2 173 ? 32.101  37.370 104.591 1.00 18.50 ? 192 THR L N   1 
ATOM   3013 C  CA  . THR B 2 173 ? 31.590  38.558 105.263 1.00 17.29 ? 192 THR L CA  1 
ATOM   3014 C  C   . THR B 2 173 ? 30.341  39.109 104.576 1.00 18.00 ? 192 THR L C   1 
ATOM   3015 O  O   . THR B 2 173 ? 30.024  38.784 103.424 1.00 19.58 ? 192 THR L O   1 
ATOM   3016 C  CB  . THR B 2 173 ? 32.668  39.654 105.352 1.00 17.01 ? 192 THR L CB  1 
ATOM   3017 O  OG1 . THR B 2 173 ? 33.086  40.061 104.056 1.00 19.94 ? 192 THR L OG1 1 
ATOM   3018 C  CG2 . THR B 2 173 ? 33.869  39.208 106.130 1.00 20.55 ? 192 THR L CG2 1 
ATOM   3019 N  N   . TYR B 2 174 ? 29.688  40.013 105.301 1.00 17.77 ? 193 TYR L N   1 
ATOM   3020 C  CA  . TYR B 2 174 ? 28.597  40.833 104.839 1.00 17.38 ? 193 TYR L CA  1 
ATOM   3021 C  C   . TYR B 2 174 ? 28.991  42.325 104.848 1.00 17.66 ? 193 TYR L C   1 
ATOM   3022 O  O   . TYR B 2 174 ? 29.935  42.727 105.539 1.00 19.09 ? 193 TYR L O   1 
ATOM   3023 C  CB  . TYR B 2 174 ? 27.424  40.680 105.805 1.00 20.46 ? 193 TYR L CB  1 
ATOM   3024 C  CG  . TYR B 2 174 ? 26.831  39.296 105.914 1.00 19.23 ? 193 TYR L CG  1 
ATOM   3025 C  CD1 . TYR B 2 174 ? 25.892  38.869 105.008 1.00 18.71 ? 193 TYR L CD1 1 
ATOM   3026 C  CD2 . TYR B 2 174 ? 27.214  38.411 106.895 1.00 18.02 ? 193 TYR L CD2 1 
ATOM   3027 C  CE1 . TYR B 2 174 ? 25.366  37.579 105.037 1.00 20.38 ? 193 TYR L CE1 1 
ATOM   3028 C  CE2 . TYR B 2 174 ? 26.706  37.125 106.955 1.00 20.13 ? 193 TYR L CE2 1 
ATOM   3029 C  CZ  . TYR B 2 174 ? 25.768  36.704 106.037 1.00 20.58 ? 193 TYR L CZ  1 
ATOM   3030 O  OH  . TYR B 2 174 ? 25.204  35.445 106.139 1.00 23.01 ? 193 TYR L OH  1 
ATOM   3031 N  N   . SER B 2 175 ? 28.224  43.136 104.128 1.00 18.92 ? 194 SER L N   1 
ATOM   3032 C  CA  . SER B 2 175 ? 28.211  44.595 104.288 1.00 18.79 ? 194 SER L CA  1 
ATOM   3033 C  C   . SER B 2 175 ? 26.775  45.082 104.405 1.00 17.94 ? 194 SER L C   1 
ATOM   3034 O  O   . SER B 2 175 ? 25.812  44.426 103.966 1.00 18.51 ? 194 SER L O   1 
ATOM   3035 C  CB  . SER B 2 175 ? 28.929  45.250 103.133 1.00 19.14 ? 194 SER L CB  1 
ATOM   3036 O  OG  . SER B 2 175 ? 30.312  44.939 103.130 1.00 20.69 ? 194 SER L OG  1 
ATOM   3037 N  N   . LEU B 2 176 ? 26.594  46.228 105.051 1.00 17.66 ? 195 LEU L N   1 
ATOM   3038 C  CA  . LEU B 2 176 ? 25.285  46.769 105.393 1.00 18.34 ? 195 LEU L CA  1 
ATOM   3039 C  C   . LEU B 2 176 ? 25.300  48.264 105.132 1.00 19.98 ? 195 LEU L C   1 
ATOM   3040 O  O   . LEU B 2 176 ? 26.283  48.927 105.469 1.00 20.58 ? 195 LEU L O   1 
ATOM   3041 C  CB  . LEU B 2 176 ? 24.976  46.445 106.860 1.00 20.13 ? 195 LEU L CB  1 
ATOM   3042 C  CG  . LEU B 2 176 ? 23.663  46.967 107.458 1.00 19.93 ? 195 LEU L CG  1 
ATOM   3043 C  CD1 . LEU B 2 176 ? 23.286  46.110 108.650 1.00 23.87 ? 195 LEU L CD1 1 
ATOM   3044 C  CD2 . LEU B 2 176 ? 23.791  48.426 107.868 1.00 21.53 ? 195 LEU L CD2 1 
ATOM   3045 N  N   . SER B 2 177 ? 24.200  48.755 104.547 1.00 19.64 ? 196 SER L N   1 
ATOM   3046 C  CA  A SER B 2 177 ? 23.997  50.190 104.356 0.50 20.12 ? 196 SER L CA  1 
ATOM   3047 C  CA  B SER B 2 177 ? 23.997  50.183 104.347 0.50 21.99 ? 196 SER L CA  1 
ATOM   3048 C  C   . SER B 2 177 ? 22.828  50.611 105.229 1.00 21.74 ? 196 SER L C   1 
ATOM   3049 O  O   . SER B 2 177 ? 21.833  49.901 105.276 1.00 24.58 ? 196 SER L O   1 
ATOM   3050 C  CB  A SER B 2 177 ? 23.701  50.517 102.921 0.50 20.05 ? 196 SER L CB  1 
ATOM   3051 C  CB  B SER B 2 177 ? 23.745  50.421 102.883 0.50 24.36 ? 196 SER L CB  1 
ATOM   3052 O  OG  A SER B 2 177 ? 22.378  50.105 102.586 0.50 19.18 ? 196 SER L OG  1 
ATOM   3053 O  OG  B SER B 2 177 ? 23.572  51.788 102.592 0.50 28.68 ? 196 SER L OG  1 
ATOM   3054 N  N   . SER B 2 178 ? 22.963  51.725 105.970 1.00 19.78 ? 197 SER L N   1 
ATOM   3055 C  CA  . SER B 2 178 ? 21.821  52.300 106.669 1.00 21.93 ? 197 SER L CA  1 
ATOM   3056 C  C   . SER B 2 178 ? 21.656  53.730 106.151 1.00 21.75 ? 197 SER L C   1 
ATOM   3057 O  O   . SER B 2 178 ? 22.610  54.505 106.093 1.00 23.95 ? 197 SER L O   1 
ATOM   3058 C  CB  . SER B 2 178 ? 21.960  52.263 108.156 1.00 22.79 ? 197 SER L CB  1 
ATOM   3059 O  OG  . SER B 2 178 ? 20.859  52.866 108.841 1.00 24.43 ? 197 SER L OG  1 
ATOM   3060 N  N   . THR B 2 179 ? 20.432  54.073 105.757 1.00 20.94 ? 198 THR L N   1 
ATOM   3061 C  CA  . THR B 2 179 ? 20.142  55.396 105.242 1.00 21.86 ? 198 THR L CA  1 
ATOM   3062 C  C   . THR B 2 179 ? 19.115  56.066 106.158 1.00 20.31 ? 198 THR L C   1 
ATOM   3063 O  O   . THR B 2 179 ? 18.015  55.539 106.353 1.00 21.09 ? 198 THR L O   1 
ATOM   3064 C  CB  . THR B 2 179 ? 19.560  55.312 103.825 1.00 26.81 ? 198 THR L CB  1 
ATOM   3065 O  OG1 . THR B 2 179 ? 20.464  54.573 103.001 1.00 28.57 ? 198 THR L OG1 1 
ATOM   3066 C  CG2 . THR B 2 179 ? 19.260  56.707 103.317 1.00 27.98 ? 198 THR L CG2 1 
ATOM   3067 N  N   . LEU B 2 180 ? 19.493  57.224 106.712 1.00 20.42 ? 199 LEU L N   1 
ATOM   3068 C  CA  . LEU B 2 180 ? 18.632  58.131 107.469 1.00 20.29 ? 199 LEU L CA  1 
ATOM   3069 C  C   . LEU B 2 180 ? 18.083  59.155 106.488 1.00 20.55 ? 199 LEU L C   1 
ATOM   3070 O  O   . LEU B 2 180 ? 18.859  59.762 105.778 1.00 23.01 ? 199 LEU L O   1 
ATOM   3071 C  CB  . LEU B 2 180 ? 19.487  58.852 108.516 1.00 20.66 ? 199 LEU L CB  1 
ATOM   3072 C  CG  . LEU B 2 180 ? 18.781  59.860 109.417 1.00 22.57 ? 199 LEU L CG  1 
ATOM   3073 C  CD1 . LEU B 2 180 ? 17.816  59.147 110.340 1.00 26.36 ? 199 LEU L CD1 1 
ATOM   3074 C  CD2 . LEU B 2 180 ? 19.751  60.690 110.253 1.00 24.30 ? 199 LEU L CD2 1 
ATOM   3075 N  N   . THR B 2 181 ? 16.753  59.316 106.450 1.00 24.70 ? 200 THR L N   1 
ATOM   3076 C  CA  . THR B 2 181 ? 16.143  60.262 105.534 1.00 28.66 ? 200 THR L CA  1 
ATOM   3077 C  C   . THR B 2 181 ? 15.399  61.328 106.316 1.00 27.19 ? 200 THR L C   1 
ATOM   3078 O  O   . THR B 2 181 ? 14.599  60.999 107.190 1.00 29.15 ? 200 THR L O   1 
ATOM   3079 C  CB  . THR B 2 181 ? 15.161  59.630 104.548 1.00 32.71 ? 200 THR L CB  1 
ATOM   3080 O  OG1 . THR B 2 181 ? 15.786  58.519 103.913 1.00 34.18 ? 200 THR L OG1 1 
ATOM   3081 C  CG2 . THR B 2 181 ? 14.753  60.658 103.507 1.00 34.91 ? 200 THR L CG2 1 
ATOM   3082 N  N   . LEU B 2 182 ? 15.744  62.603 106.033 1.00 29.73 ? 201 LEU L N   1 
ATOM   3083 C  CA  . LEU B 2 182 ? 15.072  63.735 106.645 1.00 32.12 ? 201 LEU L CA  1 
ATOM   3084 C  C   . LEU B 2 182 ? 14.696  64.731 105.564 1.00 30.38 ? 201 LEU L C   1 
ATOM   3085 O  O   . LEU B 2 182 ? 15.407  64.833 104.563 1.00 29.52 ? 201 LEU L O   1 
ATOM   3086 C  CB  . LEU B 2 182 ? 16.025  64.453 107.615 1.00 34.84 ? 201 LEU L CB  1 
ATOM   3087 C  CG  . LEU B 2 182 ? 16.712  63.563 108.640 1.00 38.34 ? 201 LEU L CG  1 
ATOM   3088 C  CD1 . LEU B 2 182 ? 17.865  64.307 109.265 1.00 40.84 ? 201 LEU L CD1 1 
ATOM   3089 C  CD2 . LEU B 2 182 ? 15.714  63.125 109.701 1.00 43.12 ? 201 LEU L CD2 1 
ATOM   3090 N  N   . SER B 2 183 ? 13.692  65.571 105.858 1.00 31.94 ? 202 SER L N   1 
ATOM   3091 C  CA  . SER B 2 183 ? 13.506  66.776 105.059 1.00 35.56 ? 202 SER L CA  1 
ATOM   3092 C  C   . SER B 2 183 ? 14.736  67.681 105.188 1.00 36.37 ? 202 SER L C   1 
ATOM   3093 O  O   . SER B 2 183 ? 15.465  67.651 106.187 1.00 34.83 ? 202 SER L O   1 
ATOM   3094 C  CB  . SER B 2 183 ? 12.258  67.535 105.476 1.00 34.52 ? 202 SER L CB  1 
ATOM   3095 O  OG  . SER B 2 183 ? 12.402  68.067 106.778 1.00 32.83 ? 202 SER L OG  1 
ATOM   3096 N  N   . LYS B 2 184 ? 14.963  68.490 104.158 1.00 36.20 ? 203 LYS L N   1 
ATOM   3097 C  CA  . LYS B 2 184 ? 16.004  69.501 104.217 1.00 39.70 ? 203 LYS L CA  1 
ATOM   3098 C  C   . LYS B 2 184 ? 15.730  70.441 105.396 1.00 39.80 ? 203 LYS L C   1 
ATOM   3099 O  O   . LYS B 2 184 ? 16.640  70.831 106.120 1.00 34.39 ? 203 LYS L O   1 
ATOM   3100 C  CB  . LYS B 2 184 ? 16.057  70.195 102.856 1.00 44.15 ? 203 LYS L CB  1 
ATOM   3101 C  CG  . LYS B 2 184 ? 17.115  71.274 102.718 1.00 49.16 ? 203 LYS L CG  1 
ATOM   3102 C  CD  . LYS B 2 184 ? 16.928  72.111 101.479 1.00 53.22 ? 203 LYS L CD  1 
ATOM   3103 C  CE  . LYS B 2 184 ? 18.025  73.140 101.318 1.00 55.45 ? 203 LYS L CE  1 
ATOM   3104 N  NZ  . LYS B 2 184 ? 18.371  73.339 99.893  1.00 62.84 ? 203 LYS L NZ  1 
ATOM   3105 N  N   . ALA B 2 185 ? 14.455  70.763 105.667 1.00 36.39 ? 204 ALA L N   1 
ATOM   3106 C  CA  . ALA B 2 185 ? 14.171  71.679 106.766 1.00 38.36 ? 204 ALA L CA  1 
ATOM   3107 C  C   . ALA B 2 185 ? 14.671  71.100 108.087 1.00 36.30 ? 204 ALA L C   1 
ATOM   3108 O  O   . ALA B 2 185 ? 15.186  71.841 108.931 1.00 42.23 ? 204 ALA L O   1 
ATOM   3109 C  CB  . ALA B 2 185 ? 12.692  71.954 106.872 1.00 42.35 ? 204 ALA L CB  1 
ATOM   3110 N  N   . ASP B 2 186 ? 14.435  69.796 108.297 1.00 31.98 ? 205 ASP L N   1 
ATOM   3111 C  CA  . ASP B 2 186 ? 14.780  69.166 109.563 1.00 35.47 ? 205 ASP L CA  1 
ATOM   3112 C  C   . ASP B 2 186 ? 16.297  69.036 109.636 1.00 29.48 ? 205 ASP L C   1 
ATOM   3113 O  O   . ASP B 2 186 ? 16.894  69.289 110.687 1.00 32.74 ? 205 ASP L O   1 
ATOM   3114 C  CB  . ASP B 2 186 ? 14.043  67.835 109.744 1.00 38.47 ? 205 ASP L CB  1 
ATOM   3115 C  CG  . ASP B 2 186 ? 12.594  67.996 110.177 1.00 49.30 ? 205 ASP L CG  1 
ATOM   3116 O  OD1 . ASP B 2 186 ? 12.241  69.111 110.611 1.00 51.61 ? 205 ASP L OD1 1 
ATOM   3117 O  OD2 . ASP B 2 186 ? 11.832  67.002 110.091 1.00 45.91 ? 205 ASP L OD2 1 
ATOM   3118 N  N   . TYR B 2 187 ? 16.893  68.633 108.514 1.00 30.86 ? 206 TYR L N   1 
ATOM   3119 C  CA  . TYR B 2 187 ? 18.336  68.477 108.378 1.00 31.54 ? 206 TYR L CA  1 
ATOM   3120 C  C   . TYR B 2 187 ? 19.039  69.766 108.819 1.00 32.14 ? 206 TYR L C   1 
ATOM   3121 O  O   . TYR B 2 187 ? 20.004  69.748 109.586 1.00 27.91 ? 206 TYR L O   1 
ATOM   3122 C  CB  . TYR B 2 187 ? 18.691  68.023 106.958 1.00 31.48 ? 206 TYR L CB  1 
ATOM   3123 C  CG  . TYR B 2 187 ? 20.167  67.794 106.740 1.00 30.62 ? 206 TYR L CG  1 
ATOM   3124 C  CD1 . TYR B 2 187 ? 20.811  66.746 107.374 1.00 27.76 ? 206 TYR L CD1 1 
ATOM   3125 C  CD2 . TYR B 2 187 ? 20.927  68.619 105.929 1.00 26.73 ? 206 TYR L CD2 1 
ATOM   3126 C  CE1 . TYR B 2 187 ? 22.169  66.530 107.209 1.00 26.08 ? 206 TYR L CE1 1 
ATOM   3127 C  CE2 . TYR B 2 187 ? 22.282  68.402 105.730 1.00 27.71 ? 206 TYR L CE2 1 
ATOM   3128 C  CZ  . TYR B 2 187 ? 22.918  67.371 106.413 1.00 26.39 ? 206 TYR L CZ  1 
ATOM   3129 O  OH  . TYR B 2 187 ? 24.289  67.212 106.263 1.00 26.14 ? 206 TYR L OH  1 
ATOM   3130 N  N   . GLU B 2 188 ? 18.502  70.926 108.413 1.00 31.98 ? 207 GLU L N   1 
ATOM   3131 C  CA  . GLU B 2 188 ? 19.219  72.173 108.643 1.00 35.43 ? 207 GLU L CA  1 
ATOM   3132 C  C   . GLU B 2 188 ? 18.998  72.738 110.049 1.00 33.45 ? 207 GLU L C   1 
ATOM   3133 O  O   . GLU B 2 188 ? 19.677  73.684 110.430 1.00 32.86 ? 207 GLU L O   1 
ATOM   3134 C  CB  . GLU B 2 188 ? 18.824  73.174 107.557 1.00 38.42 ? 207 GLU L CB  1 
ATOM   3135 C  CG  . GLU B 2 188 ? 19.207  72.699 106.181 1.00 46.45 ? 207 GLU L CG  1 
ATOM   3136 C  CD  . GLU B 2 188 ? 18.945  73.743 105.110 1.00 55.89 ? 207 GLU L CD  1 
ATOM   3137 O  OE1 . GLU B 2 188 ? 19.760  73.839 104.169 1.00 61.82 ? 207 GLU L OE1 1 
ATOM   3138 O  OE2 . GLU B 2 188 ? 17.961  74.498 105.263 1.00 60.15 ? 207 GLU L OE2 1 
ATOM   3139 N  N   . LYS B 2 189 ? 18.132  72.102 110.842 1.00 33.18 ? 208 LYS L N   1 
ATOM   3140 C  CA  . LYS B 2 189 ? 17.926  72.487 112.224 1.00 35.24 ? 208 LYS L CA  1 
ATOM   3141 C  C   . LYS B 2 189 ? 18.918  71.813 113.168 1.00 33.44 ? 208 LYS L C   1 
ATOM   3142 O  O   . LYS B 2 189 ? 18.901  72.151 114.353 1.00 36.22 ? 208 LYS L O   1 
ATOM   3143 C  CB  . LYS B 2 189 ? 16.482  72.204 112.652 1.00 39.40 ? 208 LYS L CB  1 
ATOM   3144 C  CG  . LYS B 2 189 ? 15.473  73.235 112.139 1.00 46.07 ? 208 LYS L CG  1 
ATOM   3145 C  CD  . LYS B 2 189 ? 14.147  73.235 112.869 1.00 57.18 ? 208 LYS L CD  1 
ATOM   3146 C  CE  . LYS B 2 189 ? 13.287  72.030 112.550 1.00 69.25 ? 208 LYS L CE  1 
ATOM   3147 N  NZ  . LYS B 2 189 ? 12.666  72.125 111.204 1.00 75.83 ? 208 LYS L NZ  1 
ATOM   3148 N  N   . HIS B 2 190 ? 19.814  70.945 112.647 1.00 28.86 ? 209 HIS L N   1 
ATOM   3149 C  CA  . HIS B 2 190 ? 20.699  70.174 113.507 1.00 29.89 ? 209 HIS L CA  1 
ATOM   3150 C  C   . HIS B 2 190 ? 22.139  70.217 113.004 1.00 25.24 ? 209 HIS L C   1 
ATOM   3151 O  O   . HIS B 2 190 ? 22.392  70.466 111.836 1.00 28.57 ? 209 HIS L O   1 
ATOM   3152 C  CB  . HIS B 2 190 ? 20.158  68.745 113.639 1.00 27.81 ? 209 HIS L CB  1 
ATOM   3153 C  CG  . HIS B 2 190 ? 18.846  68.712 114.352 1.00 33.23 ? 209 HIS L CG  1 
ATOM   3154 N  ND1 . HIS B 2 190 ? 18.739  68.837 115.721 1.00 37.68 ? 209 HIS L ND1 1 
ATOM   3155 C  CD2 . HIS B 2 190 ? 17.603  68.569 113.885 1.00 36.54 ? 209 HIS L CD2 1 
ATOM   3156 C  CE1 . HIS B 2 190 ? 17.453  68.762 116.058 1.00 38.67 ? 209 HIS L CE1 1 
ATOM   3157 N  NE2 . HIS B 2 190 ? 16.750  68.590 114.951 1.00 41.26 ? 209 HIS L NE2 1 
ATOM   3158 N  N   . LYS B 2 191 ? 23.089  69.970 113.909 1.00 25.66 ? 210 LYS L N   1 
ATOM   3159 C  CA  . LYS B 2 191 ? 24.490  70.077 113.540 1.00 25.22 ? 210 LYS L CA  1 
ATOM   3160 C  C   . LYS B 2 191 ? 25.188  68.720 113.422 1.00 22.42 ? 210 LYS L C   1 
ATOM   3161 O  O   . LYS B 2 191 ? 25.812  68.490 112.392 1.00 22.43 ? 210 LYS L O   1 
ATOM   3162 C  CB  . LYS B 2 191 ? 25.293  70.849 114.583 1.00 26.75 ? 210 LYS L CB  1 
ATOM   3163 C  CG  . LYS B 2 191 ? 26.763  71.047 114.251 1.00 29.25 ? 210 LYS L CG  1 
ATOM   3164 C  CD  . LYS B 2 191 ? 27.530  71.666 115.426 1.00 37.02 ? 210 LYS L CD  1 
ATOM   3165 C  CE  . LYS B 2 191 ? 28.941  72.115 115.106 1.00 43.81 ? 210 LYS L CE  1 
ATOM   3166 N  NZ  . LYS B 2 191 ? 29.693  72.401 116.355 1.00 44.23 ? 210 LYS L NZ  1 
ATOM   3167 N  N   . VAL B 2 192 ? 25.067  67.882 114.450 1.00 24.66 ? 211 VAL L N   1 
ATOM   3168 C  CA  . VAL B 2 192 ? 25.863  66.663 114.534 1.00 23.86 ? 211 VAL L CA  1 
ATOM   3169 C  C   . VAL B 2 192 ? 25.051  65.452 114.074 1.00 21.58 ? 211 VAL L C   1 
ATOM   3170 O  O   . VAL B 2 192 ? 24.038  65.126 114.692 1.00 22.73 ? 211 VAL L O   1 
ATOM   3171 C  CB  . VAL B 2 192 ? 26.400  66.402 115.958 1.00 24.76 ? 211 VAL L CB  1 
ATOM   3172 C  CG1 . VAL B 2 192 ? 27.308  65.195 115.975 1.00 24.43 ? 211 VAL L CG1 1 
ATOM   3173 C  CG2 . VAL B 2 192 ? 27.140  67.592 116.542 1.00 26.36 ? 211 VAL L CG2 1 
ATOM   3174 N  N   . TYR B 2 193 ? 25.579  64.754 113.059 1.00 21.12 ? 212 TYR L N   1 
ATOM   3175 C  CA  . TYR B 2 193 ? 24.952  63.546 112.529 1.00 20.68 ? 212 TYR L CA  1 
ATOM   3176 C  C   . TYR B 2 193 ? 25.895  62.367 112.797 1.00 19.02 ? 212 TYR L C   1 
ATOM   3177 O  O   . TYR B 2 193 ? 27.034  62.429 112.390 1.00 20.39 ? 212 TYR L O   1 
ATOM   3178 C  CB  . TYR B 2 193 ? 24.654  63.709 111.033 1.00 21.36 ? 212 TYR L CB  1 
ATOM   3179 C  CG  . TYR B 2 193 ? 23.528  64.680 110.810 1.00 23.00 ? 212 TYR L CG  1 
ATOM   3180 C  CD1 . TYR B 2 193 ? 23.768  66.050 110.800 1.00 25.43 ? 212 TYR L CD1 1 
ATOM   3181 C  CD2 . TYR B 2 193 ? 22.220  64.226 110.762 1.00 24.42 ? 212 TYR L CD2 1 
ATOM   3182 C  CE1 . TYR B 2 193 ? 22.723  66.953 110.691 1.00 26.10 ? 212 TYR L CE1 1 
ATOM   3183 C  CE2 . TYR B 2 193 ? 21.159  65.110 110.654 1.00 26.04 ? 212 TYR L CE2 1 
ATOM   3184 C  CZ  . TYR B 2 193 ? 21.429  66.472 110.650 1.00 26.40 ? 212 TYR L CZ  1 
ATOM   3185 O  OH  . TYR B 2 193 ? 20.358  67.313 110.533 1.00 29.50 ? 212 TYR L OH  1 
ATOM   3186 N  N   . ALA B 2 194 ? 25.390  61.356 113.476 1.00 20.73 ? 213 ALA L N   1 
ATOM   3187 C  CA  . ALA B 2 194 ? 26.218  60.264 113.955 1.00 19.57 ? 213 ALA L CA  1 
ATOM   3188 C  C   . ALA B 2 194 ? 25.550  58.927 113.709 1.00 21.91 ? 213 ALA L C   1 
ATOM   3189 O  O   . ALA B 2 194 ? 24.359  58.747 113.945 1.00 20.40 ? 213 ALA L O   1 
ATOM   3190 C  CB  . ALA B 2 194 ? 26.487  60.431 115.416 1.00 21.03 ? 213 ALA L CB  1 
ATOM   3191 N  N   . CYS B 2 195 ? 26.376  57.949 113.330 1.00 19.02 ? 214 CYS L N   1 
ATOM   3192 C  CA  A CYS B 2 195 ? 25.982  56.555 113.187 0.50 17.53 ? 214 CYS L CA  1 
ATOM   3193 C  CA  B CYS B 2 195 ? 25.860  56.594 113.340 0.50 18.57 ? 214 CYS L CA  1 
ATOM   3194 C  C   . CYS B 2 195 ? 26.740  55.754 114.255 1.00 18.25 ? 214 CYS L C   1 
ATOM   3195 O  O   . CYS B 2 195 ? 27.952  55.766 114.150 1.00 19.04 ? 214 CYS L O   1 
ATOM   3196 C  CB  A CYS B 2 195 ? 26.370  56.125 111.768 0.50 18.18 ? 214 CYS L CB  1 
ATOM   3197 C  CB  B CYS B 2 195 ? 25.705  55.991 111.952 0.50 20.67 ? 214 CYS L CB  1 
ATOM   3198 S  SG  A CYS B 2 195 ? 26.061  54.387 111.325 0.50 18.45 ? 214 CYS L SG  1 
ATOM   3199 S  SG  B CYS B 2 195 ? 27.287  55.602 111.168 0.50 22.71 ? 214 CYS L SG  1 
ATOM   3200 N  N   . GLU B 2 196 ? 26.053  55.092 115.201 1.00 17.70 ? 215 GLU L N   1 
ATOM   3201 C  CA  . GLU B 2 196 ? 26.705  54.298 116.243 1.00 21.19 ? 215 GLU L CA  1 
ATOM   3202 C  C   . GLU B 2 196 ? 26.430  52.832 115.964 1.00 19.09 ? 215 GLU L C   1 
ATOM   3203 O  O   . GLU B 2 196 ? 25.294  52.402 115.794 1.00 19.19 ? 215 GLU L O   1 
ATOM   3204 C  CB  . GLU B 2 196 ? 26.226  54.680 117.635 1.00 23.58 ? 215 GLU L CB  1 
ATOM   3205 C  CG  . GLU B 2 196 ? 26.782  53.768 118.707 1.00 22.93 ? 215 GLU L CG  1 
ATOM   3206 C  CD  . GLU B 2 196 ? 25.943  53.784 119.972 1.00 33.25 ? 215 GLU L CD  1 
ATOM   3207 O  OE1 . GLU B 2 196 ? 24.821  53.171 119.966 1.00 36.21 ? 215 GLU L OE1 1 
ATOM   3208 O  OE2 . GLU B 2 196 ? 26.364  54.468 120.889 1.00 41.04 ? 215 GLU L OE2 1 
ATOM   3209 N  N   . VAL B 2 197 ? 27.515  52.073 115.861 1.00 17.65 ? 216 VAL L N   1 
ATOM   3210 C  CA  . VAL B 2 197 ? 27.491  50.685 115.482 1.00 16.36 ? 216 VAL L CA  1 
ATOM   3211 C  C   . VAL B 2 197 ? 27.924  49.762 116.622 1.00 16.44 ? 216 VAL L C   1 
ATOM   3212 O  O   . VAL B 2 197 ? 28.950  49.967 117.243 1.00 18.05 ? 216 VAL L O   1 
ATOM   3213 C  CB  . VAL B 2 197 ? 28.380  50.453 114.264 1.00 17.74 ? 216 VAL L CB  1 
ATOM   3214 C  CG1 . VAL B 2 197 ? 28.426  48.971 113.925 1.00 17.34 ? 216 VAL L CG1 1 
ATOM   3215 C  CG2 . VAL B 2 197 ? 27.899  51.291 113.082 1.00 18.03 ? 216 VAL L CG2 1 
ATOM   3216 N  N   . THR B 2 198 ? 27.043  48.789 116.915 1.00 17.61 ? 217 THR L N   1 
ATOM   3217 C  CA  . THR B 2 198 ? 27.252  47.758 117.915 1.00 16.66 ? 217 THR L CA  1 
ATOM   3218 C  C   . THR B 2 198 ? 27.308  46.428 117.180 1.00 18.06 ? 217 THR L C   1 
ATOM   3219 O  O   . THR B 2 198 ? 26.477  46.153 116.316 1.00 20.09 ? 217 THR L O   1 
ATOM   3220 C  CB  . THR B 2 198 ? 26.084  47.777 118.921 1.00 18.69 ? 217 THR L CB  1 
ATOM   3221 O  OG1 . THR B 2 198 ? 26.057  49.058 119.531 1.00 21.05 ? 217 THR L OG1 1 
ATOM   3222 C  CG2 . THR B 2 198 ? 26.188  46.686 119.958 1.00 22.64 ? 217 THR L CG2 1 
ATOM   3223 N  N   . HIS B 2 199 ? 28.352  45.627 117.457 1.00 18.31 ? 218 HIS L N   1 
ATOM   3224 C  CA  . HIS B 2 199 ? 28.586  44.398 116.742 1.00 17.54 ? 218 HIS L CA  1 
ATOM   3225 C  C   . HIS B 2 199 ? 29.486  43.519 117.589 1.00 18.79 ? 218 HIS L C   1 
ATOM   3226 O  O   . HIS B 2 199 ? 30.357  44.033 118.297 1.00 18.78 ? 218 HIS L O   1 
ATOM   3227 C  CB  . HIS B 2 199 ? 29.250  44.652 115.384 1.00 16.63 ? 218 HIS L CB  1 
ATOM   3228 C  CG  . HIS B 2 199 ? 29.418  43.418 114.563 1.00 15.81 ? 218 HIS L CG  1 
ATOM   3229 N  ND1 . HIS B 2 199 ? 30.544  42.638 114.536 1.00 17.00 ? 218 HIS L ND1 1 
ATOM   3230 C  CD2 . HIS B 2 199 ? 28.536  42.828 113.725 1.00 15.91 ? 218 HIS L CD2 1 
ATOM   3231 C  CE1 . HIS B 2 199 ? 30.362  41.604 113.738 1.00 17.18 ? 218 HIS L CE1 1 
ATOM   3232 N  NE2 . HIS B 2 199 ? 29.126  41.684 113.239 1.00 14.76 ? 218 HIS L NE2 1 
ATOM   3233 N  N   . GLN B 2 200 ? 29.307  42.214 117.466 1.00 18.37 ? 219 GLN L N   1 
ATOM   3234 C  CA  . GLN B 2 200 ? 30.047  41.251 118.279 1.00 21.87 ? 219 GLN L CA  1 
ATOM   3235 C  C   . GLN B 2 200 ? 31.563  41.403 118.112 1.00 21.32 ? 219 GLN L C   1 
ATOM   3236 O  O   . GLN B 2 200 ? 32.334  41.125 119.054 1.00 21.44 ? 219 GLN L O   1 
ATOM   3237 C  CB  . GLN B 2 200 ? 29.625  39.838 117.866 1.00 28.51 ? 219 GLN L CB  1 
ATOM   3238 C  CG  . GLN B 2 200 ? 30.451  38.785 118.572 1.00 33.57 ? 219 GLN L CG  1 
ATOM   3239 C  CD  . GLN B 2 200 ? 29.857  37.406 118.493 1.00 47.33 ? 219 GLN L CD  1 
ATOM   3240 O  OE1 . GLN B 2 200 ? 29.712  36.717 119.502 1.00 56.90 ? 219 GLN L OE1 1 
ATOM   3241 N  NE2 . GLN B 2 200 ? 29.571  36.978 117.276 1.00 47.28 ? 219 GLN L NE2 1 
ATOM   3242 N  N   . GLY B 2 201 ? 32.032  41.870 116.951 1.00 19.26 ? 220 GLY L N   1 
ATOM   3243 C  CA  . GLY B 2 201 ? 33.452  41.969 116.674 1.00 18.46 ? 220 GLY L CA  1 
ATOM   3244 C  C   . GLY B 2 201 ? 34.045  43.244 117.258 1.00 20.08 ? 220 GLY L C   1 
ATOM   3245 O  O   . GLY B 2 201 ? 35.244  43.394 117.274 1.00 20.29 ? 220 GLY L O   1 
ATOM   3246 N  N   . LEU B 2 202 ? 33.190  44.184 117.687 1.00 17.97 ? 221 LEU L N   1 
ATOM   3247 C  CA  . LEU B 2 202 ? 33.704  45.439 118.233 1.00 17.13 ? 221 LEU L CA  1 
ATOM   3248 C  C   . LEU B 2 202 ? 33.699  45.313 119.751 1.00 20.14 ? 221 LEU L C   1 
ATOM   3249 O  O   . LEU B 2 202 ? 32.679  45.012 120.359 1.00 21.85 ? 221 LEU L O   1 
ATOM   3250 C  CB  . LEU B 2 202 ? 32.773  46.584 117.827 1.00 16.16 ? 221 LEU L CB  1 
ATOM   3251 C  CG  . LEU B 2 202 ? 32.680  46.874 116.339 1.00 17.92 ? 221 LEU L CG  1 
ATOM   3252 C  CD1 . LEU B 2 202 ? 31.609  47.935 116.040 1.00 18.54 ? 221 LEU L CD1 1 
ATOM   3253 C  CD2 . LEU B 2 202 ? 34.015  47.324 115.730 1.00 19.86 ? 221 LEU L CD2 1 
ATOM   3254 N  N   . SER B 2 203 ? 34.847  45.507 120.370 1.00 17.81 ? 222 SER L N   1 
ATOM   3255 C  CA  . SER B 2 203 ? 34.970  45.425 121.820 1.00 18.64 ? 222 SER L CA  1 
ATOM   3256 C  C   . SER B 2 203 ? 34.116  46.479 122.489 1.00 19.15 ? 222 SER L C   1 
ATOM   3257 O  O   . SER B 2 203 ? 33.628  46.274 123.590 1.00 18.27 ? 222 SER L O   1 
ATOM   3258 C  CB  . SER B 2 203 ? 36.423  45.717 122.161 1.00 19.74 ? 222 SER L CB  1 
ATOM   3259 O  OG  . SER B 2 203 ? 37.268  44.762 121.564 1.00 21.69 ? 222 SER L OG  1 
ATOM   3260 N  N   . SER B 2 204 ? 33.966  47.621 121.787 1.00 15.99 ? 223 SER L N   1 
ATOM   3261 C  CA  . SER B 2 204 ? 33.087  48.706 122.200 1.00 17.03 ? 223 SER L CA  1 
ATOM   3262 C  C   . SER B 2 204 ? 32.475  49.290 120.934 1.00 17.48 ? 223 SER L C   1 
ATOM   3263 O  O   . SER B 2 204 ? 33.108  49.254 119.866 1.00 19.06 ? 223 SER L O   1 
ATOM   3264 C  CB  A SER B 2 204 ? 33.840  49.763 123.045 0.50 17.52 ? 223 SER L CB  1 
ATOM   3265 C  CB  B SER B 2 204 ? 33.803  49.838 122.902 0.50 15.08 ? 223 SER L CB  1 
ATOM   3266 O  OG  A SER B 2 204 ? 35.155  50.042 122.571 0.50 20.38 ? 223 SER L OG  1 
ATOM   3267 O  OG  B SER B 2 204 ? 34.499  49.378 124.022 0.50 13.79 ? 223 SER L OG  1 
ATOM   3268 N  N   . PRO B 2 205 ? 31.265  49.839 121.034 1.00 19.29 ? 224 PRO L N   1 
ATOM   3269 C  CA  . PRO B 2 205 ? 30.604  50.395 119.860 1.00 18.67 ? 224 PRO L CA  1 
ATOM   3270 C  C   . PRO B 2 205 ? 31.417  51.514 119.211 1.00 19.70 ? 224 PRO L C   1 
ATOM   3271 O  O   . PRO B 2 205 ? 32.169  52.230 119.871 1.00 22.66 ? 224 PRO L O   1 
ATOM   3272 C  CB  . PRO B 2 205 ? 29.264  50.910 120.407 1.00 20.51 ? 224 PRO L CB  1 
ATOM   3273 C  CG  . PRO B 2 205 ? 29.024  50.181 121.707 1.00 22.19 ? 224 PRO L CG  1 
ATOM   3274 C  CD  . PRO B 2 205 ? 30.419  49.925 122.239 1.00 21.67 ? 224 PRO L CD  1 
ATOM   3275 N  N   . VAL B 2 206 ? 31.262  51.650 117.890 1.00 16.90 ? 225 VAL L N   1 
ATOM   3276 C  CA  . VAL B 2 206 ? 32.015  52.623 117.127 1.00 15.76 ? 225 VAL L CA  1 
ATOM   3277 C  C   . VAL B 2 206 ? 31.022  53.660 116.611 1.00 17.45 ? 225 VAL L C   1 
ATOM   3278 O  O   . VAL B 2 206 ? 30.044  53.275 116.005 1.00 18.88 ? 225 VAL L O   1 
ATOM   3279 C  CB  . VAL B 2 206 ? 32.800  51.967 115.975 1.00 17.20 ? 225 VAL L CB  1 
ATOM   3280 C  CG1 . VAL B 2 206 ? 33.273  52.974 114.955 1.00 17.55 ? 225 VAL L CG1 1 
ATOM   3281 C  CG2 . VAL B 2 206 ? 33.985  51.222 116.488 1.00 17.41 ? 225 VAL L CG2 1 
ATOM   3282 N  N   . THR B 2 207 ? 31.329  54.957 116.790 1.00 18.62 ? 226 THR L N   1 
ATOM   3283 C  CA  . THR B 2 207 ? 30.484  56.024 116.295 1.00 19.93 ? 226 THR L CA  1 
ATOM   3284 C  C   . THR B 2 207 ? 31.262  56.819 115.268 1.00 18.50 ? 226 THR L C   1 
ATOM   3285 O  O   . THR B 2 207 ? 32.396  57.226 115.490 1.00 19.90 ? 226 THR L O   1 
ATOM   3286 C  CB  . THR B 2 207 ? 30.008  56.991 117.395 1.00 21.82 ? 226 THR L CB  1 
ATOM   3287 O  OG1 . THR B 2 207 ? 29.265  56.248 118.366 1.00 20.14 ? 226 THR L OG1 1 
ATOM   3288 C  CG2 . THR B 2 207 ? 29.147  58.124 116.837 1.00 22.51 ? 226 THR L CG2 1 
ATOM   3289 N  N   . LYS B 2 208 ? 30.650  56.991 114.107 1.00 18.04 ? 227 LYS L N   1 
ATOM   3290 C  CA  . LYS B 2 208 ? 31.157  57.882 113.081 1.00 18.94 ? 227 LYS L CA  1 
ATOM   3291 C  C   . LYS B 2 208 ? 30.195  59.043 112.916 1.00 18.72 ? 227 LYS L C   1 
ATOM   3292 O  O   . LYS B 2 208 ? 28.991  58.828 112.890 1.00 22.16 ? 227 LYS L O   1 
ATOM   3293 C  CB  . LYS B 2 208 ? 31.256  57.124 111.764 1.00 21.03 ? 227 LYS L CB  1 
ATOM   3294 C  CG  . LYS B 2 208 ? 32.346  56.077 111.791 1.00 21.02 ? 227 LYS L CG  1 
ATOM   3295 C  CD  . LYS B 2 208 ? 33.668  56.605 112.299 1.00 23.41 ? 227 LYS L CD  1 
ATOM   3296 C  CE  . LYS B 2 208 ? 34.792  55.612 112.084 1.00 25.97 ? 227 LYS L CE  1 
ATOM   3297 N  NZ  . LYS B 2 208 ? 35.271  55.612 110.681 1.00 29.93 ? 227 LYS L NZ  1 
ATOM   3298 N  N   . SER B 2 209 ? 30.746  60.258 112.812 1.00 22.53 ? 228 SER L N   1 
ATOM   3299 C  CA  . SER B 2 209 ? 29.900  61.434 112.783 1.00 24.72 ? 228 SER L CA  1 
ATOM   3300 C  C   . SER B 2 209 ? 30.497  62.530 111.888 1.00 24.02 ? 228 SER L C   1 
ATOM   3301 O  O   . SER B 2 209 ? 31.650  62.487 111.453 1.00 23.74 ? 228 SER L O   1 
ATOM   3302 C  CB  . SER B 2 209 ? 29.662  61.931 114.170 1.00 26.36 ? 228 SER L CB  1 
ATOM   3303 O  OG  . SER B 2 209 ? 30.874  62.388 114.711 1.00 32.30 ? 228 SER L OG  1 
ATOM   3304 N  N   . PHE B 2 210 ? 29.641  63.509 111.567 1.00 21.69 ? 229 PHE L N   1 
ATOM   3305 C  CA  . PHE B 2 210 ? 30.108  64.724 110.920 1.00 21.99 ? 229 PHE L CA  1 
ATOM   3306 C  C   . PHE B 2 210 ? 29.248  65.880 111.405 1.00 22.63 ? 229 PHE L C   1 
ATOM   3307 O  O   . PHE B 2 210 ? 28.155  65.672 111.925 1.00 21.41 ? 229 PHE L O   1 
ATOM   3308 C  CB  . PHE B 2 210 ? 30.026  64.636 109.412 1.00 22.86 ? 229 PHE L CB  1 
ATOM   3309 C  CG  . PHE B 2 210 ? 28.625  64.504 108.866 1.00 19.97 ? 229 PHE L CG  1 
ATOM   3310 C  CD1 . PHE B 2 210 ? 28.071  63.254 108.605 1.00 19.84 ? 229 PHE L CD1 1 
ATOM   3311 C  CD2 . PHE B 2 210 ? 27.867  65.628 108.524 1.00 22.59 ? 229 PHE L CD2 1 
ATOM   3312 C  CE1 . PHE B 2 210 ? 26.773  63.122 108.127 1.00 22.61 ? 229 PHE L CE1 1 
ATOM   3313 C  CE2 . PHE B 2 210 ? 26.570  65.486 108.052 1.00 22.75 ? 229 PHE L CE2 1 
ATOM   3314 C  CZ  . PHE B 2 210 ? 26.032  64.243 107.806 1.00 22.44 ? 229 PHE L CZ  1 
ATOM   3315 N  N   . ASN B 2 211 ? 29.769  67.093 111.161 1.00 23.99 ? 230 ASN L N   1 
ATOM   3316 C  CA  . ASN B 2 211 ? 28.995  68.274 111.439 1.00 24.60 ? 230 ASN L CA  1 
ATOM   3317 C  C   . ASN B 2 211 ? 28.491  68.821 110.113 1.00 24.14 ? 230 ASN L C   1 
ATOM   3318 O  O   . ASN B 2 211 ? 29.245  68.954 109.160 1.00 26.86 ? 230 ASN L O   1 
ATOM   3319 C  CB  . ASN B 2 211 ? 29.776  69.371 112.129 1.00 27.28 ? 230 ASN L CB  1 
ATOM   3320 C  CG  . ASN B 2 211 ? 30.455  68.941 113.400 1.00 27.97 ? 230 ASN L CG  1 
ATOM   3321 O  OD1 . ASN B 2 211 ? 31.617  69.285 113.612 1.00 39.35 ? 230 ASN L OD1 1 
ATOM   3322 N  ND2 . ASN B 2 211 ? 29.770  68.195 114.245 1.00 27.41 ? 230 ASN L ND2 1 
ATOM   3323 N  N   . ARG B 2 212 ? 27.203  69.128 110.055 1.00 25.09 ? 231 ARG L N   1 
ATOM   3324 C  CA  . ARG B 2 212 ? 26.601  69.557 108.805 1.00 27.13 ? 231 ARG L CA  1 
ATOM   3325 C  C   . ARG B 2 212 ? 27.307  70.800 108.273 1.00 31.26 ? 231 ARG L C   1 
ATOM   3326 O  O   . ARG B 2 212 ? 27.596  71.699 109.050 1.00 30.86 ? 231 ARG L O   1 
ATOM   3327 C  CB  . ARG B 2 212 ? 25.114  69.828 109.013 1.00 28.59 ? 231 ARG L CB  1 
ATOM   3328 C  CG  . ARG B 2 212 ? 24.453  70.596 107.874 1.00 31.53 ? 231 ARG L CG  1 
ATOM   3329 C  CD  . ARG B 2 212 ? 22.972  70.744 108.197 1.00 32.39 ? 231 ARG L CD  1 
ATOM   3330 N  NE  . ARG B 2 212 ? 22.756  71.585 109.364 1.00 33.53 ? 231 ARG L NE  1 
ATOM   3331 C  CZ  . ARG B 2 212 ? 22.983  72.884 109.397 1.00 40.63 ? 231 ARG L CZ  1 
ATOM   3332 N  NH1 . ARG B 2 212 ? 23.156  73.554 108.270 1.00 43.25 ? 231 ARG L NH1 1 
ATOM   3333 N  NH2 . ARG B 2 212 ? 22.988  73.512 110.557 1.00 41.65 ? 231 ARG L NH2 1 
ATOM   3334 N  N   . GLY B 2 213 ? 27.597  70.775 106.967 1.00 36.14 ? 232 GLY L N   1 
ATOM   3335 C  CA  . GLY B 2 213 ? 28.142  71.905 106.235 1.00 43.77 ? 232 GLY L CA  1 
ATOM   3336 C  C   . GLY B 2 213 ? 29.654  72.121 106.380 1.00 50.75 ? 232 GLY L C   1 
ATOM   3337 O  O   . GLY B 2 213 ? 30.114  73.226 106.107 1.00 52.66 ? 232 GLY L O   1 
ATOM   3338 N  N   . GLU B 2 214 ? 30.447  71.120 106.799 1.00 51.60 ? 233 GLU L N   1 
ATOM   3339 C  CA  . GLU B 2 214 ? 31.868  71.375 107.065 1.00 52.97 ? 233 GLU L CA  1 
ATOM   3340 C  C   . GLU B 2 214 ? 32.780  70.865 105.939 1.00 48.13 ? 233 GLU L C   1 
ATOM   3341 O  O   . GLU B 2 214 ? 32.435  69.855 105.301 1.00 60.83 ? 233 GLU L O   1 
ATOM   3342 C  CB  . GLU B 2 214 ? 32.294  70.807 108.420 1.00 51.42 ? 233 GLU L CB  1 
ATOM   3343 C  CG  . GLU B 2 214 ? 31.734  71.613 109.583 1.00 56.85 ? 233 GLU L CG  1 
ATOM   3344 C  CD  . GLU B 2 214 ? 32.387  71.459 110.952 1.00 60.12 ? 233 GLU L CD  1 
ATOM   3345 O  OE1 . GLU B 2 214 ? 33.378  70.706 111.061 1.00 64.63 ? 233 GLU L OE1 1 
ATOM   3346 O  OE2 . GLU B 2 214 ? 31.891  72.100 111.926 1.00 58.42 ? 233 GLU L OE2 1 
HETATM 3347 C  C1  . GCS C 3 .   ? 2.797   13.766 85.911  1.00 38.54 ? 1   GCS A C1  1 
HETATM 3348 C  C2  . GCS C 3 .   ? 2.638   14.763 87.062  1.00 32.01 ? 1   GCS A C2  1 
HETATM 3349 C  C3  . GCS C 3 .   ? 3.515   15.978 86.725  1.00 31.68 ? 1   GCS A C3  1 
HETATM 3350 C  C4  . GCS C 3 .   ? 4.937   15.502 86.857  1.00 33.48 ? 1   GCS A C4  1 
HETATM 3351 C  C5  . GCS C 3 .   ? 5.141   14.439 85.786  1.00 37.48 ? 1   GCS A C5  1 
HETATM 3352 C  C6  . GCS C 3 .   ? 6.539   13.901 85.838  1.00 43.32 ? 1   GCS A C6  1 
HETATM 3353 N  N2  . GCS C 3 .   ? 1.267   14.942 87.536  1.00 28.89 ? 1   GCS A N2  1 
HETATM 3354 O  O1  . GCS C 3 .   ? 1.904   12.686 85.978  1.00 46.50 ? 1   GCS A O1  1 
HETATM 3355 O  O3  . GCS C 3 .   ? 3.232   17.141 87.488  1.00 22.72 ? 1   GCS A O3  1 
HETATM 3356 O  O4  . GCS C 3 .   ? 5.946   16.501 86.766  1.00 32.12 ? 1   GCS A O4  1 
HETATM 3357 O  O5  . GCS C 3 .   ? 4.163   13.382 85.944  1.00 32.75 ? 1   GCS A O5  1 
HETATM 3358 O  O6  . GCS C 3 .   ? 6.728   12.521 85.598  1.00 56.65 ? 1   GCS A O6  1 
HETATM 3359 C  C1  . GCS C 3 .   ? 7.454   12.427 84.318  1.00 58.86 ? 2   GCS A C1  1 
HETATM 3360 C  C2  . GCS C 3 .   ? 8.965   12.737 84.363  1.00 49.59 ? 2   GCS A C2  1 
HETATM 3361 C  C3  . GCS C 3 .   ? 9.416   12.837 82.908  1.00 53.36 ? 2   GCS A C3  1 
HETATM 3362 C  C4  . GCS C 3 .   ? 9.279   11.446 82.321  1.00 51.07 ? 2   GCS A C4  1 
HETATM 3363 C  C5  . GCS C 3 .   ? 7.785   11.133 82.313  1.00 55.72 ? 2   GCS A C5  1 
HETATM 3364 C  C6  . GCS C 3 .   ? 7.441   9.800  81.683  1.00 53.88 ? 2   GCS A C6  1 
HETATM 3365 N  N2  . GCS C 3 .   ? 9.443   13.887 85.143  1.00 39.43 ? 2   GCS A N2  1 
HETATM 3366 O  O3  . GCS C 3 .   ? 10.716  13.374 82.736  1.00 46.99 ? 2   GCS A O3  1 
HETATM 3367 O  O4  . GCS C 3 .   ? 9.846   11.428 81.019  1.00 52.82 ? 2   GCS A O4  1 
HETATM 3368 O  O5  . GCS C 3 .   ? 7.328   11.154 83.685  1.00 58.93 ? 2   GCS A O5  1 
HETATM 3369 O  O6  . GCS C 3 .   ? 6.650   8.959  82.513  1.00 49.55 ? 2   GCS A O6  1 
HETATM 3370 S  S   . SO4 D 4 .   ? 7.964   40.103 74.156  1.00 37.57 ? 301 SO4 H S   1 
HETATM 3371 O  O1  . SO4 D 4 .   ? 8.579   40.012 72.860  1.00 54.30 ? 301 SO4 H O1  1 
HETATM 3372 O  O2  . SO4 D 4 .   ? 6.552   40.387 74.010  1.00 46.81 ? 301 SO4 H O2  1 
HETATM 3373 O  O3  . SO4 D 4 .   ? 8.175   38.835 74.833  1.00 38.06 ? 301 SO4 H O3  1 
HETATM 3374 O  O4  . SO4 D 4 .   ? 8.562   41.164 74.938  1.00 44.86 ? 301 SO4 H O4  1 
HETATM 3375 S  S   . SO4 E 4 .   ? -6.438  22.022 77.134  0.50 27.28 ? 302 SO4 H S   1 
HETATM 3376 O  O1  . SO4 E 4 .   ? -5.871  22.941 76.184  0.50 26.59 ? 302 SO4 H O1  1 
HETATM 3377 O  O2  . SO4 E 4 .   ? -7.569  21.331 76.555  0.50 27.61 ? 302 SO4 H O2  1 
HETATM 3378 O  O3  . SO4 E 4 .   ? -5.456  21.080 77.541  0.50 27.48 ? 302 SO4 H O3  1 
HETATM 3379 O  O4  . SO4 E 4 .   ? -6.862  22.770 78.293  0.50 25.72 ? 302 SO4 H O4  1 
HETATM 3380 S  S   . SO4 F 4 .   ? 11.060  58.972 84.270  0.50 39.25 ? 303 SO4 H S   1 
HETATM 3381 O  O1  . SO4 F 4 .   ? 11.672  59.627 83.135  0.50 43.73 ? 303 SO4 H O1  1 
HETATM 3382 O  O2  . SO4 F 4 .   ? 10.931  57.557 83.982  0.50 41.07 ? 303 SO4 H O2  1 
HETATM 3383 O  O3  . SO4 F 4 .   ? 9.752   59.536 84.525  0.50 41.54 ? 303 SO4 H O3  1 
HETATM 3384 O  O4  . SO4 F 4 .   ? 11.888  59.169 85.440  0.50 43.75 ? 303 SO4 H O4  1 
HETATM 3385 S  S   . SO4 G 4 .   ? 36.321  59.639 110.940 1.00 68.14 ? 304 SO4 H S   1 
HETATM 3386 O  O1  . SO4 G 4 .   ? 36.425  58.273 110.423 1.00 48.69 ? 304 SO4 H O1  1 
HETATM 3387 O  O2  . SO4 G 4 .   ? 35.191  60.298 110.330 1.00 78.81 ? 304 SO4 H O2  1 
HETATM 3388 O  O3  . SO4 G 4 .   ? 37.522  60.385 110.623 1.00 68.41 ? 304 SO4 H O3  1 
HETATM 3389 O  O4  . SO4 G 4 .   ? 36.131  59.612 112.376 1.00 57.67 ? 304 SO4 H O4  1 
HETATM 3390 CL CL  . CL  H 5 .   ? 4.958   25.064 95.455  1.00 19.34 ? 305 CL  H CL  1 
HETATM 3391 S  S   . SO4 I 4 .   ? 40.295  37.126 106.882 1.00 34.61 ? 301 SO4 L S   1 
HETATM 3392 O  O1  . SO4 I 4 .   ? 40.963  36.096 106.165 1.00 42.79 ? 301 SO4 L O1  1 
HETATM 3393 O  O2  . SO4 I 4 .   ? 39.109  37.514 106.191 1.00 40.65 ? 301 SO4 L O2  1 
HETATM 3394 O  O3  . SO4 I 4 .   ? 39.977  36.599 108.176 1.00 37.90 ? 301 SO4 L O3  1 
HETATM 3395 O  O4  . SO4 I 4 .   ? 41.133  38.320 107.028 1.00 35.55 ? 301 SO4 L O4  1 
HETATM 3396 S  S   . SO4 J 4 .   ? 34.604  18.553 95.707  1.00 28.13 ? 302 SO4 L S   1 
HETATM 3397 O  O1  . SO4 J 4 .   ? 35.132  18.303 94.354  1.00 33.32 ? 302 SO4 L O1  1 
HETATM 3398 O  O2  . SO4 J 4 .   ? 33.241  18.796 95.660  1.00 24.59 ? 302 SO4 L O2  1 
HETATM 3399 O  O3  . SO4 J 4 .   ? 34.890  17.452 96.625  1.00 38.85 ? 302 SO4 L O3  1 
HETATM 3400 O  O4  . SO4 J 4 .   ? 35.200  19.772 96.209  1.00 36.81 ? 302 SO4 L O4  1 
HETATM 3401 S  S   . SO4 K 4 .   ? 34.805  15.050 101.289 1.00 38.15 ? 303 SO4 L S   1 
HETATM 3402 O  O1  . SO4 K 4 .   ? 35.149  13.698 100.885 1.00 43.67 ? 303 SO4 L O1  1 
HETATM 3403 O  O2  . SO4 K 4 .   ? 33.833  15.599 100.307 1.00 33.74 ? 303 SO4 L O2  1 
HETATM 3404 O  O3  . SO4 K 4 .   ? 36.002  15.869 101.313 1.00 33.61 ? 303 SO4 L O3  1 
HETATM 3405 O  O4  . SO4 K 4 .   ? 34.193  15.007 102.583 1.00 32.44 ? 303 SO4 L O4  1 
HETATM 3406 S  S   . SO4 L 4 .   ? 29.084  16.793 84.272  0.50 30.79 ? 304 SO4 L S   1 
HETATM 3407 O  O1  . SO4 L 4 .   ? 29.069  16.752 82.832  0.50 33.91 ? 304 SO4 L O1  1 
HETATM 3408 O  O2  . SO4 L 4 .   ? 29.136  18.157 84.716  0.50 31.65 ? 304 SO4 L O2  1 
HETATM 3409 O  O3  . SO4 L 4 .   ? 30.239  16.098 84.783  0.50 28.49 ? 304 SO4 L O3  1 
HETATM 3410 O  O4  . SO4 L 4 .   ? 27.891  16.181 84.763  0.50 26.33 ? 304 SO4 L O4  1 
HETATM 3411 S  S   . SO4 M 4 .   ? 37.298  47.516 104.947 1.00 60.03 ? 305 SO4 L S   1 
HETATM 3412 O  O1  . SO4 M 4 .   ? 38.162  46.984 103.923 1.00 66.21 ? 305 SO4 L O1  1 
HETATM 3413 O  O2  . SO4 M 4 .   ? 36.476  48.574 104.369 1.00 45.78 ? 305 SO4 L O2  1 
HETATM 3414 O  O3  . SO4 M 4 .   ? 36.409  46.469 105.441 1.00 42.19 ? 305 SO4 L O3  1 
HETATM 3415 O  O4  . SO4 M 4 .   ? 38.137  48.043 106.048 1.00 49.79 ? 305 SO4 L O4  1 
HETATM 3416 O  O   . HOH N 6 .   ? 8.402   17.392 85.348  0.50 30.58 ? 401 HOH H O   1 
HETATM 3417 O  O   . HOH N 6 .   ? 9.975   15.345 80.950  0.50 20.11 ? 402 HOH H O   1 
HETATM 3418 O  O   . HOH N 6 .   ? 33.109  60.247 110.395 1.00 40.94 ? 403 HOH H O   1 
HETATM 3419 O  O   . HOH N 6 .   ? 8.691   57.615 84.265  0.50 39.09 ? 404 HOH H O   1 
HETATM 3420 O  O   . HOH N 6 .   ? -8.159  20.058 78.379  1.00 56.87 ? 405 HOH H O   1 
HETATM 3421 O  O   . HOH N 6 .   ? 36.643  57.994 113.954 1.00 42.05 ? 406 HOH H O   1 
HETATM 3422 O  O   . HOH N 6 .   ? 17.210  46.414 91.539  1.00 37.18 ? 407 HOH H O   1 
HETATM 3423 O  O   . HOH N 6 .   ? -7.004  21.369 93.855  1.00 39.68 ? 408 HOH H O   1 
HETATM 3424 O  O   . HOH N 6 .   ? 14.277  12.361 87.199  0.50 20.16 ? 409 HOH H O   1 
HETATM 3425 O  O   . HOH N 6 .   ? -2.716  21.713 90.779  1.00 37.77 ? 410 HOH H O   1 
HETATM 3426 O  O   . HOH N 6 .   ? -6.204  22.920 80.640  1.00 32.85 ? 411 HOH H O   1 
HETATM 3427 O  O   . HOH N 6 .   ? 26.623  45.685 87.212  1.00 52.01 ? 412 HOH H O   1 
HETATM 3428 O  O   . HOH N 6 .   ? 17.458  51.916 79.915  1.00 41.17 ? 413 HOH H O   1 
HETATM 3429 O  O   . HOH N 6 .   ? 32.530  60.942 103.611 1.00 36.41 ? 414 HOH H O   1 
HETATM 3430 O  O   . HOH N 6 .   ? 13.755  59.561 90.677  1.00 40.68 ? 415 HOH H O   1 
HETATM 3431 O  O   . HOH N 6 .   ? 4.350   40.425 75.185  1.00 19.89 ? 416 HOH H O   1 
HETATM 3432 O  O   . HOH N 6 .   ? 2.360   24.373 69.774  1.00 28.20 ? 417 HOH H O   1 
HETATM 3433 O  O   . HOH N 6 .   ? -8.246  30.395 91.323  1.00 33.98 ? 418 HOH H O   1 
HETATM 3434 O  O   . HOH N 6 .   ? 9.345   44.578 96.172  1.00 35.37 ? 419 HOH H O   1 
HETATM 3435 O  O   . HOH N 6 .   ? -10.074 27.037 90.864  1.00 22.15 ? 420 HOH H O   1 
HETATM 3436 O  O   . HOH N 6 .   ? 41.447  51.285 107.452 1.00 33.71 ? 421 HOH H O   1 
HETATM 3437 O  O   . HOH N 6 .   ? 24.164  27.817 80.602  1.00 41.79 ? 422 HOH H O   1 
HETATM 3438 O  O   . HOH N 6 .   ? 8.218   33.212 70.562  1.00 21.84 ? 423 HOH H O   1 
HETATM 3439 O  O   . HOH N 6 .   ? 0.867   50.760 86.523  1.00 33.77 ? 424 HOH H O   1 
HETATM 3440 O  O   . HOH N 6 .   ? -1.463  12.762 76.633  1.00 38.25 ? 425 HOH H O   1 
HETATM 3441 O  O   . HOH N 6 .   ? -0.902  30.512 94.900  1.00 35.04 ? 426 HOH H O   1 
HETATM 3442 O  O   . HOH N 6 .   ? 18.405  35.437 87.285  1.00 38.35 ? 427 HOH H O   1 
HETATM 3443 O  O   . HOH N 6 .   ? 43.595  53.667 88.291  1.00 42.46 ? 428 HOH H O   1 
HETATM 3444 O  O   . HOH N 6 .   ? 22.252  19.722 76.774  1.00 36.22 ? 429 HOH H O   1 
HETATM 3445 O  O   . HOH N 6 .   ? 14.451  39.308 77.792  1.00 39.92 ? 430 HOH H O   1 
HETATM 3446 O  O   . HOH N 6 .   ? 6.082   37.397 75.366  1.00 21.07 ? 431 HOH H O   1 
HETATM 3447 O  O   . HOH N 6 .   ? 2.123   44.226 93.540  1.00 31.08 ? 432 HOH H O   1 
HETATM 3448 O  O   . HOH N 6 .   ? 10.565  58.556 98.232  1.00 29.74 ? 433 HOH H O   1 
HETATM 3449 O  O   . HOH N 6 .   ? -6.086  31.478 78.330  1.00 17.34 ? 434 HOH H O   1 
HETATM 3450 O  O   . HOH N 6 .   ? 33.267  57.873 108.824 1.00 28.66 ? 435 HOH H O   1 
HETATM 3451 O  O   . HOH N 6 .   ? -4.921  19.653 79.664  1.00 46.79 ? 436 HOH H O   1 
HETATM 3452 O  O   . HOH N 6 .   ? 40.134  60.364 101.028 1.00 43.69 ? 437 HOH H O   1 
HETATM 3453 O  O   . HOH N 6 .   ? -9.777  39.371 82.736  1.00 30.52 ? 438 HOH H O   1 
HETATM 3454 O  O   . HOH N 6 .   ? 5.577   28.255 65.137  1.00 30.96 ? 439 HOH H O   1 
HETATM 3455 O  O   . HOH N 6 .   ? -8.840  24.489 78.042  1.00 31.42 ? 440 HOH H O   1 
HETATM 3456 O  O   . HOH N 6 .   ? 22.885  15.206 84.422  1.00 29.35 ? 441 HOH H O   1 
HETATM 3457 O  O   . HOH N 6 .   ? 33.790  47.904 99.415  1.00 38.44 ? 442 HOH H O   1 
HETATM 3458 O  O   . HOH N 6 .   ? -0.113  30.216 76.623  1.00 15.08 ? 443 HOH H O   1 
HETATM 3459 O  O   . HOH N 6 .   ? 1.379   18.601 70.084  1.00 25.83 ? 444 HOH H O   1 
HETATM 3460 O  O   . HOH N 6 .   ? 37.971  62.579 109.165 1.00 40.60 ? 445 HOH H O   1 
HETATM 3461 O  O   . HOH N 6 .   ? 5.917   51.394 100.413 1.00 45.97 ? 446 HOH H O   1 
HETATM 3462 O  O   . HOH N 6 .   ? -4.879  25.031 79.662  1.00 18.71 ? 447 HOH H O   1 
HETATM 3463 O  O   . HOH N 6 .   ? 14.716  21.432 70.936  1.00 34.31 ? 448 HOH H O   1 
HETATM 3464 O  O   . HOH N 6 .   ? 17.992  15.015 76.807  1.00 30.59 ? 449 HOH H O   1 
HETATM 3465 O  O   . HOH N 6 .   ? 3.111   35.611 93.356  1.00 26.96 ? 450 HOH H O   1 
HETATM 3466 O  O   . HOH N 6 .   ? 19.444  49.783 99.502  1.00 36.37 ? 451 HOH H O   1 
HETATM 3467 O  O   . HOH N 6 .   ? 16.254  35.897 89.755  1.00 27.04 ? 452 HOH H O   1 
HETATM 3468 O  O   . HOH N 6 .   ? -5.576  33.577 80.149  1.00 18.57 ? 453 HOH H O   1 
HETATM 3469 O  O   . HOH N 6 .   ? -8.605  37.494 97.770  1.00 33.22 ? 454 HOH H O   1 
HETATM 3470 O  O   . HOH N 6 .   ? 38.090  64.827 103.484 1.00 28.11 ? 455 HOH H O   1 
HETATM 3471 O  O   . HOH N 6 .   ? 38.286  48.455 93.769  1.00 30.51 ? 456 HOH H O   1 
HETATM 3472 O  O   . HOH N 6 .   ? 20.933  28.444 81.238  1.00 33.51 ? 457 HOH H O   1 
HETATM 3473 O  O   . HOH N 6 .   ? 8.448   37.834 71.313  1.00 36.44 ? 458 HOH H O   1 
HETATM 3474 O  O   . HOH N 6 .   ? 16.421  26.669 70.122  1.00 36.29 ? 459 HOH H O   1 
HETATM 3475 O  O   . HOH N 6 .   ? 10.165  45.653 85.884  1.00 27.03 ? 460 HOH H O   1 
HETATM 3476 O  O   . HOH N 6 .   ? -1.494  46.199 93.033  1.00 38.64 ? 461 HOH H O   1 
HETATM 3477 O  O   . HOH N 6 .   ? -9.726  43.201 83.619  1.00 31.56 ? 462 HOH H O   1 
HETATM 3478 O  O   . HOH N 6 .   ? 13.229  35.870 92.612  1.00 25.20 ? 463 HOH H O   1 
HETATM 3479 O  O   . HOH N 6 .   ? 45.861  60.584 93.046  1.00 45.37 ? 464 HOH H O   1 
HETATM 3480 O  O   . HOH N 6 .   ? -1.988  24.761 76.304  1.00 23.56 ? 465 HOH H O   1 
HETATM 3481 O  O   . HOH N 6 .   ? 32.218  65.485 95.613  1.00 44.71 ? 466 HOH H O   1 
HETATM 3482 O  O   . HOH N 6 .   ? 16.677  47.774 84.827  1.00 36.10 ? 467 HOH H O   1 
HETATM 3483 O  O   . HOH N 6 .   ? 14.570  39.300 82.610  1.00 43.75 ? 468 HOH H O   1 
HETATM 3484 O  O   . HOH N 6 .   ? -2.463  33.378 92.369  1.00 29.31 ? 469 HOH H O   1 
HETATM 3485 O  O   . HOH N 6 .   ? 28.361  42.486 97.635  1.00 31.25 ? 470 HOH H O   1 
HETATM 3486 O  O   . HOH N 6 .   ? 26.811  46.253 90.793  1.00 32.11 ? 471 HOH H O   1 
HETATM 3487 O  O   . HOH N 6 .   ? 19.468  44.307 89.045  1.00 48.26 ? 472 HOH H O   1 
HETATM 3488 O  O   . HOH N 6 .   ? -5.971  48.617 87.181  1.00 35.14 ? 473 HOH H O   1 
HETATM 3489 O  O   . HOH N 6 .   ? 12.385  60.558 100.448 1.00 38.27 ? 474 HOH H O   1 
HETATM 3490 O  O   . HOH N 6 .   ? 6.243   42.489 72.339  1.00 45.35 ? 475 HOH H O   1 
HETATM 3491 O  O   . HOH N 6 .   ? 11.984  35.325 75.127  1.00 28.39 ? 476 HOH H O   1 
HETATM 3492 O  O   . HOH N 6 .   ? 12.889  35.415 98.232  1.00 32.17 ? 477 HOH H O   1 
HETATM 3493 O  O   . HOH N 6 .   ? 31.048  62.176 101.499 1.00 28.44 ? 478 HOH H O   1 
HETATM 3494 O  O   . HOH N 6 .   ? 10.751  32.455 71.144  1.00 24.69 ? 479 HOH H O   1 
HETATM 3495 O  O   . HOH N 6 .   ? 41.571  59.748 106.871 1.00 32.28 ? 480 HOH H O   1 
HETATM 3496 O  O   . HOH N 6 .   ? 40.790  51.669 91.137  1.00 30.18 ? 481 HOH H O   1 
HETATM 3497 O  O   . HOH N 6 .   ? 31.042  47.295 87.473  1.00 29.02 ? 482 HOH H O   1 
HETATM 3498 O  O   . HOH N 6 .   ? 3.553   40.718 77.910  1.00 18.70 ? 483 HOH H O   1 
HETATM 3499 O  O   . HOH N 6 .   ? 5.892   18.018 69.482  1.00 43.01 ? 484 HOH H O   1 
HETATM 3500 O  O   . HOH N 6 .   ? 7.205   35.582 71.876  1.00 21.59 ? 485 HOH H O   1 
HETATM 3501 O  O   . HOH N 6 .   ? 45.787  55.062 107.182 1.00 30.36 ? 486 HOH H O   1 
HETATM 3502 O  O   . HOH N 6 .   ? -6.186  27.419 80.470  1.00 26.40 ? 487 HOH H O   1 
HETATM 3503 O  O   . HOH N 6 .   ? 31.975  64.259 103.138 1.00 42.17 ? 488 HOH H O   1 
HETATM 3504 O  O   . HOH N 6 .   ? 2.954   38.862 95.317  1.00 24.57 ? 489 HOH H O   1 
HETATM 3505 O  O   . HOH N 6 .   ? -4.781  25.387 76.845  1.00 20.49 ? 490 HOH H O   1 
HETATM 3506 O  O   . HOH N 6 .   ? 2.357   25.186 93.850  1.00 25.39 ? 491 HOH H O   1 
HETATM 3507 O  O   . HOH N 6 .   ? 2.361   49.378 94.044  1.00 43.17 ? 492 HOH H O   1 
HETATM 3508 O  O   . HOH N 6 .   ? 11.290  37.587 93.920  1.00 23.25 ? 493 HOH H O   1 
HETATM 3509 O  O   . HOH N 6 .   ? -7.169  42.451 81.106  1.00 36.37 ? 494 HOH H O   1 
HETATM 3510 O  O   . HOH N 6 .   ? 1.961   46.176 80.977  1.00 36.65 ? 495 HOH H O   1 
HETATM 3511 O  O   . HOH N 6 .   ? 36.048  60.529 89.910  1.00 34.97 ? 496 HOH H O   1 
HETATM 3512 O  O   . HOH N 6 .   ? 10.741  40.631 80.534  1.00 27.64 ? 497 HOH H O   1 
HETATM 3513 O  O   . HOH N 6 .   ? 4.915   30.587 69.110  1.00 20.05 ? 498 HOH H O   1 
HETATM 3514 O  O   . HOH N 6 .   ? 7.617   43.983 92.225  1.00 30.55 ? 499 HOH H O   1 
HETATM 3515 O  O   . HOH N 6 .   ? -5.918  27.396 83.532  1.00 22.44 ? 500 HOH H O   1 
HETATM 3516 O  O   . HOH N 6 .   ? 38.592  60.127 91.819  1.00 30.40 ? 501 HOH H O   1 
HETATM 3517 O  O   . HOH N 6 .   ? 29.905  43.044 93.661  1.00 40.10 ? 502 HOH H O   1 
HETATM 3518 O  O   . HOH N 6 .   ? -4.100  50.548 82.146  1.00 38.48 ? 503 HOH H O   1 
HETATM 3519 O  O   . HOH N 6 .   ? 36.462  59.887 93.532  1.00 35.08 ? 504 HOH H O   1 
HETATM 3520 O  O   . HOH N 6 .   ? 46.540  54.027 98.478  1.00 25.53 ? 505 HOH H O   1 
HETATM 3521 O  O   . HOH N 6 .   ? 4.421   25.037 66.232  1.00 33.28 ? 506 HOH H O   1 
HETATM 3522 O  O   . HOH N 6 .   ? -4.572  32.922 96.095  1.00 42.56 ? 507 HOH H O   1 
HETATM 3523 O  O   . HOH N 6 .   ? 6.951   16.013 71.969  1.00 35.75 ? 508 HOH H O   1 
HETATM 3524 O  O   . HOH N 6 .   ? 10.186  35.164 68.071  1.00 49.43 ? 509 HOH H O   1 
HETATM 3525 O  O   . HOH N 6 .   ? 15.132  22.002 86.384  1.00 19.18 ? 510 HOH H O   1 
HETATM 3526 O  O   . HOH N 6 .   ? 31.823  54.876 82.712  1.00 28.51 ? 511 HOH H O   1 
HETATM 3527 O  O   . HOH N 6 .   ? -1.064  13.281 72.619  1.00 40.53 ? 512 HOH H O   1 
HETATM 3528 O  O   . HOH N 6 .   ? 5.514   27.324 97.710  1.00 38.87 ? 513 HOH H O   1 
HETATM 3529 O  O   . HOH N 6 .   ? 18.864  33.610 80.286  1.00 34.42 ? 514 HOH H O   1 
HETATM 3530 O  O   . HOH N 6 .   ? 14.682  9.554  83.293  1.00 44.63 ? 515 HOH H O   1 
HETATM 3531 O  O   . HOH N 6 .   ? 32.842  43.011 96.825  1.00 40.67 ? 516 HOH H O   1 
HETATM 3532 O  O   . HOH N 6 .   ? -8.084  46.430 84.922  1.00 34.21 ? 517 HOH H O   1 
HETATM 3533 O  O   . HOH N 6 .   ? 0.318   44.476 79.729  1.00 35.88 ? 518 HOH H O   1 
HETATM 3534 O  O   . HOH N 6 .   ? 5.985   39.541 98.678  1.00 34.22 ? 519 HOH H O   1 
HETATM 3535 O  O   . HOH N 6 .   ? 8.096   44.405 86.987  1.00 19.55 ? 520 HOH H O   1 
HETATM 3536 O  O   . HOH N 6 .   ? 33.597  60.384 113.386 1.00 32.09 ? 521 HOH H O   1 
HETATM 3537 O  O   . HOH N 6 .   ? 11.496  20.800 70.111  1.00 51.66 ? 522 HOH H O   1 
HETATM 3538 O  O   . HOH N 6 .   ? 6.378   33.131 96.172  1.00 20.15 ? 523 HOH H O   1 
HETATM 3539 O  O   . HOH N 6 .   ? 17.649  30.304 73.953  1.00 34.74 ? 524 HOH H O   1 
HETATM 3540 O  O   . HOH N 6 .   ? 5.455   50.186 95.512  1.00 34.85 ? 525 HOH H O   1 
HETATM 3541 O  O   . HOH N 6 .   ? 9.046   22.373 87.940  1.00 21.10 ? 526 HOH H O   1 
HETATM 3542 O  O   . HOH N 6 .   ? 28.611  63.009 98.167  1.00 26.52 ? 527 HOH H O   1 
HETATM 3543 O  O   . HOH N 6 .   ? 4.177   33.169 94.780  1.00 30.54 ? 528 HOH H O   1 
HETATM 3544 O  O   . HOH N 6 .   ? 20.989  46.300 91.380  1.00 40.26 ? 529 HOH H O   1 
HETATM 3545 O  O   . HOH N 6 .   ? 15.195  61.776 94.665  1.00 40.50 ? 530 HOH H O   1 
HETATM 3546 O  O   . HOH N 6 .   ? -6.594  33.715 92.575  1.00 26.31 ? 531 HOH H O   1 
HETATM 3547 O  O   . HOH N 6 .   ? 19.311  30.338 80.905  1.00 45.71 ? 532 HOH H O   1 
HETATM 3548 O  O   . HOH N 6 .   ? 17.288  44.925 94.692  1.00 34.92 ? 533 HOH H O   1 
HETATM 3549 O  O   . HOH N 6 .   ? 18.817  53.535 99.919  1.00 48.44 ? 534 HOH H O   1 
HETATM 3550 O  O   . HOH N 6 .   ? -5.611  21.455 82.758  1.00 39.19 ? 535 HOH H O   1 
HETATM 3551 O  O   . HOH N 6 .   ? 36.213  56.270 84.658  1.00 47.08 ? 536 HOH H O   1 
HETATM 3552 O  O   . HOH N 6 .   ? 27.809  50.009 81.875  1.00 50.71 ? 537 HOH H O   1 
HETATM 3553 O  O   . HOH N 6 .   ? 12.571  37.510 96.419  1.00 31.15 ? 538 HOH H O   1 
HETATM 3554 O  O   . HOH N 6 .   ? 5.879   54.763 90.705  1.00 44.80 ? 539 HOH H O   1 
HETATM 3555 O  O   . HOH N 6 .   ? 18.161  58.155 80.053  1.00 38.83 ? 540 HOH H O   1 
HETATM 3556 O  O   . HOH N 6 .   ? 25.386  24.640 79.121  1.00 38.35 ? 541 HOH H O   1 
HETATM 3557 O  O   . HOH N 6 .   ? 48.267  52.520 96.642  1.00 38.93 ? 542 HOH H O   1 
HETATM 3558 O  O   . HOH N 6 .   ? 46.947  54.765 92.482  1.00 40.70 ? 543 HOH H O   1 
HETATM 3559 O  O   . HOH N 6 .   ? 13.228  44.250 95.790  1.00 44.66 ? 544 HOH H O   1 
HETATM 3560 O  O   . HOH N 6 .   ? 38.286  51.441 86.169  1.00 35.96 ? 545 HOH H O   1 
HETATM 3561 O  O   . HOH N 6 .   ? 10.842  55.113 104.001 1.00 43.29 ? 546 HOH H O   1 
HETATM 3562 O  O   . HOH N 6 .   ? 12.829  22.220 67.418  0.50 26.35 ? 547 HOH H O   1 
HETATM 3563 O  O   . HOH N 6 .   ? 5.315   53.397 93.109  1.00 39.95 ? 548 HOH H O   1 
HETATM 3564 O  O   . HOH N 6 .   ? 5.198   45.367 81.128  1.00 32.91 ? 549 HOH H O   1 
HETATM 3565 O  O   . HOH N 6 .   ? 10.107  41.854 77.465  1.00 40.26 ? 550 HOH H O   1 
HETATM 3566 O  O   . HOH N 6 .   ? 20.817  45.503 93.999  1.00 36.65 ? 551 HOH H O   1 
HETATM 3567 O  O   . HOH N 6 .   ? 23.984  60.517 82.383  1.00 36.01 ? 552 HOH H O   1 
HETATM 3568 O  O   . HOH N 6 .   ? 30.669  63.899 93.185  1.00 34.81 ? 553 HOH H O   1 
HETATM 3569 O  O   . HOH N 6 .   ? 9.016   46.376 91.643  1.00 27.98 ? 554 HOH H O   1 
HETATM 3570 O  O   . HOH N 6 .   ? -4.296  18.011 81.105  1.00 31.61 ? 555 HOH H O   1 
HETATM 3571 O  O   . HOH N 6 .   ? 20.202  61.695 88.383  1.00 34.93 ? 556 HOH H O   1 
HETATM 3572 O  O   . HOH N 6 .   ? 38.983  62.198 99.138  1.00 31.78 ? 557 HOH H O   1 
HETATM 3573 O  O   . HOH N 6 .   ? 12.843  41.493 85.166  1.00 33.79 ? 558 HOH H O   1 
HETATM 3574 O  O   . HOH N 6 .   ? 6.978   31.526 100.724 1.00 36.83 ? 559 HOH H O   1 
HETATM 3575 O  O   . HOH N 6 .   ? 24.255  49.594 84.625  1.00 40.73 ? 560 HOH H O   1 
HETATM 3576 O  O   . HOH N 6 .   ? 35.481  42.027 95.103  1.00 45.45 ? 561 HOH H O   1 
HETATM 3577 O  O   . HOH N 6 .   ? -7.723  31.695 88.877  1.00 23.57 ? 562 HOH H O   1 
HETATM 3578 O  O   . HOH N 6 .   ? 24.220  60.637 98.552  1.00 27.72 ? 563 HOH H O   1 
HETATM 3579 O  O   . HOH N 6 .   ? 5.686   13.000 73.156  1.00 46.00 ? 564 HOH H O   1 
HETATM 3580 O  O   . HOH N 6 .   ? 5.723   12.079 79.735  1.00 42.26 ? 565 HOH H O   1 
HETATM 3581 O  O   . HOH N 6 .   ? 16.391  55.822 100.716 1.00 36.13 ? 566 HOH H O   1 
HETATM 3582 O  O   . HOH N 6 .   ? 5.449   22.775 67.134  1.00 31.33 ? 567 HOH H O   1 
HETATM 3583 O  O   . HOH N 6 .   ? 27.537  43.609 94.779  1.00 33.68 ? 568 HOH H O   1 
HETATM 3584 O  O   . HOH N 6 .   ? 18.642  23.347 70.872  1.00 35.09 ? 569 HOH H O   1 
HETATM 3585 O  O   . HOH N 6 .   ? 4.214   22.424 69.854  1.00 21.57 ? 570 HOH H O   1 
HETATM 3586 O  O   . HOH N 6 .   ? 28.389  63.301 86.451  1.00 33.80 ? 571 HOH H O   1 
HETATM 3587 O  O   . HOH N 6 .   ? 26.662  23.378 84.297  1.00 40.35 ? 572 HOH H O   1 
HETATM 3588 O  O   . HOH N 6 .   ? 13.435  19.712 70.703  1.00 38.43 ? 573 HOH H O   1 
HETATM 3589 O  O   . HOH N 6 .   ? -1.469  43.594 77.964  1.00 37.95 ? 574 HOH H O   1 
HETATM 3590 O  O   . HOH N 6 .   ? -2.051  49.025 92.506  1.00 41.56 ? 575 HOH H O   1 
HETATM 3591 O  O   . HOH N 6 .   ? 38.222  45.779 89.320  1.00 30.96 ? 576 HOH H O   1 
HETATM 3592 O  O   . HOH N 6 .   ? 1.726   57.045 87.489  1.00 38.25 ? 577 HOH H O   1 
HETATM 3593 O  O   . HOH N 6 .   ? -7.201  40.058 81.708  1.00 20.96 ? 578 HOH H O   1 
HETATM 3594 O  O   . HOH N 6 .   ? 5.445   33.186 68.125  1.00 25.33 ? 579 HOH H O   1 
HETATM 3595 O  O   . HOH N 6 .   ? -2.946  44.699 80.439  1.00 25.86 ? 580 HOH H O   1 
HETATM 3596 O  O   . HOH N 6 .   ? 23.421  45.813 89.745  1.00 28.58 ? 581 HOH H O   1 
HETATM 3597 O  O   . HOH N 6 .   ? 37.766  52.408 102.776 1.00 28.96 ? 582 HOH H O   1 
HETATM 3598 O  O   . HOH N 6 .   ? 7.706   33.293 64.525  1.00 53.10 ? 583 HOH H O   1 
HETATM 3599 O  O   . HOH N 6 .   ? 8.504   47.358 83.760  1.00 28.18 ? 584 HOH H O   1 
HETATM 3600 O  O   . HOH N 6 .   ? 40.661  58.116 84.646  1.00 34.05 ? 585 HOH H O   1 
HETATM 3601 O  O   . HOH N 6 .   ? 48.057  51.083 104.477 1.00 45.90 ? 586 HOH H O   1 
HETATM 3602 O  O   . HOH N 6 .   ? 11.877  46.344 100.882 1.00 41.53 ? 587 HOH H O   1 
HETATM 3603 O  O   . HOH N 6 .   ? 9.201   57.677 101.915 1.00 44.06 ? 588 HOH H O   1 
HETATM 3604 O  O   . HOH N 6 .   ? -4.873  21.416 86.841  1.00 24.19 ? 589 HOH H O   1 
HETATM 3605 O  O   . HOH N 6 .   ? 24.201  53.782 82.448  1.00 39.63 ? 590 HOH H O   1 
HETATM 3606 O  O   . HOH N 6 .   ? 0.695   23.746 73.801  1.00 17.01 ? 591 HOH H O   1 
HETATM 3607 O  O   . HOH N 6 .   ? 7.324   41.081 70.054  1.00 52.48 ? 592 HOH H O   1 
HETATM 3608 O  O   . HOH N 6 .   ? -4.628  49.327 92.136  1.00 52.71 ? 593 HOH H O   1 
HETATM 3609 O  O   . HOH N 6 .   ? 40.400  64.208 102.271 1.00 40.18 ? 594 HOH H O   1 
HETATM 3610 O  O   . HOH N 6 .   ? 28.087  52.162 80.805  1.00 48.63 ? 595 HOH H O   1 
HETATM 3611 O  O   . HOH N 6 .   ? 1.938   21.824 71.859  1.00 24.19 ? 596 HOH H O   1 
HETATM 3612 O  O   . HOH N 6 .   ? 20.641  21.436 71.242  1.00 35.83 ? 597 HOH H O   1 
HETATM 3613 O  O   . HOH N 6 .   ? 7.475   19.749 84.673  1.00 32.23 ? 598 HOH H O   1 
HETATM 3614 O  O   . HOH N 6 .   ? 18.979  36.161 79.496  1.00 46.04 ? 599 HOH H O   1 
HETATM 3615 O  O   . HOH N 6 .   ? 29.388  65.025 96.601  1.00 34.89 ? 600 HOH H O   1 
HETATM 3616 O  O   . HOH N 6 .   ? 2.018   43.057 96.153  1.00 54.49 ? 601 HOH H O   1 
HETATM 3617 O  O   . HOH N 6 .   ? 2.361   37.086 97.076  1.00 41.17 ? 602 HOH H O   1 
HETATM 3618 O  O   . HOH N 6 .   ? 34.600  55.135 82.894  1.00 35.22 ? 603 HOH H O   1 
HETATM 3619 O  O   . HOH N 6 .   ? 4.124   19.476 68.797  1.00 37.19 ? 604 HOH H O   1 
HETATM 3620 O  O   . HOH N 6 .   ? 5.888   44.842 94.341  1.00 41.51 ? 605 HOH H O   1 
HETATM 3621 O  O   . HOH N 6 .   ? 48.056  60.583 96.084  1.00 27.64 ? 606 HOH H O   1 
HETATM 3622 O  O   . HOH N 6 .   ? -0.921  14.070 87.713  1.00 44.86 ? 607 HOH H O   1 
HETATM 3623 O  O   . HOH N 6 .   ? 37.839  62.540 90.195  1.00 39.77 ? 608 HOH H O   1 
HETATM 3624 O  O   . HOH N 6 .   ? 48.430  54.754 100.355 1.00 29.73 ? 609 HOH H O   1 
HETATM 3625 O  O   . HOH N 6 .   ? 29.612  45.917 89.582  1.00 40.39 ? 610 HOH H O   1 
HETATM 3626 O  O   . HOH N 6 .   ? 4.363   11.709 83.438  1.00 39.61 ? 611 HOH H O   1 
HETATM 3627 O  O   . HOH N 6 .   ? -6.194  49.693 89.958  1.00 43.99 ? 612 HOH H O   1 
HETATM 3628 O  O   . HOH N 6 .   ? 43.443  52.194 90.633  1.00 41.16 ? 613 HOH H O   1 
HETATM 3629 O  O   . HOH N 6 .   ? 10.960  34.507 72.819  1.00 35.35 ? 614 HOH H O   1 
HETATM 3630 O  O   . HOH N 6 .   ? 4.455   40.664 96.607  1.00 52.03 ? 615 HOH H O   1 
HETATM 3631 O  O   . HOH N 6 .   ? 3.799   46.759 93.677  1.00 37.75 ? 616 HOH H O   1 
HETATM 3632 O  O   . HOH N 6 .   ? 10.722  36.752 71.200  1.00 42.59 ? 617 HOH H O   1 
HETATM 3633 O  O   . HOH N 6 .   ? 7.493   28.712 100.692 1.00 31.23 ? 618 HOH H O   1 
HETATM 3634 O  O   . HOH N 6 .   ? 41.409  62.802 97.778  1.00 37.71 ? 619 HOH H O   1 
HETATM 3635 O  O   . HOH N 6 .   ? 14.254  41.193 88.193  1.00 45.49 ? 620 HOH H O   1 
HETATM 3636 O  O   . HOH N 6 .   ? 16.341  39.750 87.313  1.00 41.56 ? 621 HOH H O   1 
HETATM 3637 O  O   . HOH N 6 .   ? 11.636  40.359 93.764  1.00 33.61 ? 622 HOH H O   1 
HETATM 3638 O  O   . HOH N 6 .   ? -6.407  22.310 85.231  1.00 43.99 ? 623 HOH H O   1 
HETATM 3639 O  O   . HOH N 6 .   ? 40.287  49.270 92.375  1.00 30.20 ? 624 HOH H O   1 
HETATM 3640 O  O   . HOH N 6 .   ? 4.443   50.103 98.140  1.00 43.24 ? 625 HOH H O   1 
HETATM 3641 O  O   . HOH N 6 .   ? 4.867   43.164 96.008  1.00 46.34 ? 626 HOH H O   1 
HETATM 3642 O  O   . HOH N 6 .   ? 3.914   37.480 99.057  1.00 49.92 ? 627 HOH H O   1 
HETATM 3643 O  O   . HOH N 6 .   ? 42.800  48.150 93.208  1.00 40.92 ? 628 HOH H O   1 
HETATM 3644 O  O   . HOH O 6 .   ? 32.354  58.709 104.530 1.00 35.25 ? 401 HOH L O   1 
HETATM 3645 O  O   . HOH O 6 .   ? 36.328  50.163 102.824 1.00 39.46 ? 402 HOH L O   1 
HETATM 3646 O  O   . HOH O 6 .   ? 37.044  15.669 103.355 1.00 35.78 ? 403 HOH L O   1 
HETATM 3647 O  O   . HOH O 6 .   ? 20.302  48.198 113.062 1.00 28.59 ? 404 HOH L O   1 
HETATM 3648 O  O   . HOH O 6 .   ? 37.119  48.798 122.981 1.00 28.75 ? 405 HOH L O   1 
HETATM 3649 O  O   . HOH O 6 .   ? 20.890  34.204 87.913  1.00 38.64 ? 406 HOH L O   1 
HETATM 3650 O  O   . HOH O 6 .   ? 27.700  15.703 81.056  1.00 38.65 ? 407 HOH L O   1 
HETATM 3651 O  O   . HOH O 6 .   ? 19.411  51.159 110.001 1.00 31.60 ? 408 HOH L O   1 
HETATM 3652 O  O   . HOH O 6 .   ? -0.650  14.778 101.662 1.00 38.00 ? 409 HOH L O   1 
HETATM 3653 O  O   . HOH O 6 .   ? 20.868  45.103 111.577 1.00 39.01 ? 410 HOH L O   1 
HETATM 3654 O  O   . HOH O 6 .   ? 16.656  58.401 101.500 1.00 35.46 ? 411 HOH L O   1 
HETATM 3655 O  O   . HOH O 6 .   ? 38.827  22.593 99.971  1.00 41.02 ? 412 HOH L O   1 
HETATM 3656 O  O   . HOH O 6 .   ? 20.935  31.106 107.615 1.00 24.85 ? 413 HOH L O   1 
HETATM 3657 O  O   . HOH O 6 .   ? 23.996  11.909 95.168  1.00 27.72 ? 414 HOH L O   1 
HETATM 3658 O  O   . HOH O 6 .   ? 15.924  45.734 104.097 1.00 38.95 ? 415 HOH L O   1 
HETATM 3659 O  O   . HOH O 6 .   ? 26.212  66.138 92.781  1.00 48.10 ? 416 HOH L O   1 
HETATM 3660 O  O   . HOH O 6 .   ? 25.523  30.541 114.278 1.00 46.91 ? 417 HOH L O   1 
HETATM 3661 O  O   . HOH O 6 .   ? 42.169  34.170 104.956 1.00 42.16 ? 418 HOH L O   1 
HETATM 3662 O  O   . HOH O 6 .   ? 23.695  35.897 93.866  1.00 51.83 ? 419 HOH L O   1 
HETATM 3663 O  O   . HOH O 6 .   ? 1.795   8.972  97.488  1.00 37.82 ? 420 HOH L O   1 
HETATM 3664 O  O   . HOH O 6 .   ? 9.778   29.924 102.114 1.00 32.11 ? 421 HOH L O   1 
HETATM 3665 O  O   . HOH O 6 .   ? 15.415  54.539 102.927 1.00 36.32 ? 422 HOH L O   1 
HETATM 3666 O  O   . HOH O 6 .   ? 36.459  26.046 108.714 1.00 33.02 ? 423 HOH L O   1 
HETATM 3667 O  O   . HOH O 6 .   ? 23.558  9.853  88.432  1.00 31.96 ? 424 HOH L O   1 
HETATM 3668 O  O   . HOH O 6 .   ? 31.725  33.035 114.348 1.00 33.56 ? 425 HOH L O   1 
HETATM 3669 O  O   . HOH O 6 .   ? 19.040  52.215 112.468 1.00 35.24 ? 426 HOH L O   1 
HETATM 3670 O  O   . HOH O 6 .   ? 25.582  35.691 110.755 1.00 25.46 ? 427 HOH L O   1 
HETATM 3671 O  O   . HOH O 6 .   ? 29.813  13.592 98.441  1.00 30.06 ? 428 HOH L O   1 
HETATM 3672 O  O   . HOH O 6 .   ? 6.924   20.798 87.095  1.00 21.40 ? 429 HOH L O   1 
HETATM 3673 O  O   . HOH O 6 .   ? 15.311  31.869 98.188  1.00 21.69 ? 430 HOH L O   1 
HETATM 3674 O  O   . HOH O 6 .   ? 30.779  43.633 121.474 1.00 37.88 ? 431 HOH L O   1 
HETATM 3675 O  O   . HOH O 6 .   ? 18.926  53.723 118.489 1.00 46.50 ? 432 HOH L O   1 
HETATM 3676 O  O   . HOH O 6 .   ? 29.009  36.573 96.987  1.00 34.32 ? 433 HOH L O   1 
HETATM 3677 O  O   . HOH O 6 .   ? 36.341  27.345 97.732  1.00 39.51 ? 434 HOH L O   1 
HETATM 3678 O  O   . HOH O 6 .   ? 26.411  27.783 92.407  1.00 26.16 ? 435 HOH L O   1 
HETATM 3679 O  O   . HOH O 6 .   ? 38.230  36.550 112.497 1.00 20.12 ? 436 HOH L O   1 
HETATM 3680 O  O   . HOH O 6 .   ? 27.537  57.503 119.889 1.00 32.90 ? 437 HOH L O   1 
HETATM 3681 O  O   . HOH O 6 .   ? 32.903  13.137 103.895 1.00 20.71 ? 438 HOH L O   1 
HETATM 3682 O  O   . HOH O 6 .   ? 10.411  6.958  96.638  1.00 46.81 ? 439 HOH L O   1 
HETATM 3683 O  O   . HOH O 6 .   ? 33.822  17.496 92.228  1.00 24.88 ? 440 HOH L O   1 
HETATM 3684 O  O   . HOH O 6 .   ? 30.577  15.760 90.383  1.00 25.24 ? 441 HOH L O   1 
HETATM 3685 O  O   . HOH O 6 .   ? 24.911  69.433 118.662 1.00 42.51 ? 442 HOH L O   1 
HETATM 3686 O  O   . HOH O 6 .   ? 10.377  11.754 109.371 1.00 45.68 ? 443 HOH L O   1 
HETATM 3687 O  O   . HOH O 6 .   ? 36.415  42.323 122.066 1.00 29.45 ? 444 HOH L O   1 
HETATM 3688 O  O   . HOH O 6 .   ? 35.512  24.831 95.221  1.00 40.72 ? 445 HOH L O   1 
HETATM 3689 O  O   . HOH O 6 .   ? 15.733  56.050 105.130 1.00 27.91 ? 446 HOH L O   1 
HETATM 3690 O  O   . HOH O 6 .   ? 6.484   25.352 100.374 1.00 33.46 ? 447 HOH L O   1 
HETATM 3691 O  O   . HOH O 6 .   ? 35.087  49.820 113.107 1.00 22.59 ? 448 HOH L O   1 
HETATM 3692 O  O   . HOH O 6 .   ? 33.619  15.329 97.686  1.00 29.26 ? 449 HOH L O   1 
HETATM 3693 O  O   . HOH O 6 .   ? 27.839  14.668 99.873  1.00 23.38 ? 450 HOH L O   1 
HETATM 3694 O  O   . HOH O 6 .   ? 15.944  33.202 106.397 1.00 52.97 ? 451 HOH L O   1 
HETATM 3695 O  O   . HOH O 6 .   ? 23.529  12.719 86.627  1.00 36.66 ? 452 HOH L O   1 
HETATM 3696 O  O   . HOH O 6 .   ? 34.970  30.697 97.061  1.00 29.06 ? 453 HOH L O   1 
HETATM 3697 O  O   . HOH O 6 .   ? 22.055  13.214 101.404 1.00 16.80 ? 454 HOH L O   1 
HETATM 3698 O  O   . HOH O 6 .   ? 14.116  68.833 115.209 1.00 49.57 ? 455 HOH L O   1 
HETATM 3699 O  O   . HOH O 6 .   ? 25.446  49.578 122.065 1.00 33.10 ? 456 HOH L O   1 
HETATM 3700 O  O   . HOH O 6 .   ? 22.721  62.834 98.470  1.00 24.22 ? 457 HOH L O   1 
HETATM 3701 O  O   . HOH O 6 .   ? 35.056  31.449 104.894 1.00 33.91 ? 458 HOH L O   1 
HETATM 3702 O  O   . HOH O 6 .   ? 24.400  59.226 122.946 1.00 43.77 ? 459 HOH L O   1 
HETATM 3703 O  O   . HOH O 6 .   ? 15.670  5.122  100.996 1.00 49.50 ? 460 HOH L O   1 
HETATM 3704 O  O   . HOH O 6 .   ? 28.658  62.652 100.886 1.00 35.57 ? 461 HOH L O   1 
HETATM 3705 O  O   . HOH O 6 .   ? 16.763  51.340 110.245 1.00 46.12 ? 462 HOH L O   1 
HETATM 3706 O  O   . HOH O 6 .   ? 21.356  50.802 100.208 1.00 29.51 ? 463 HOH L O   1 
HETATM 3707 O  O   . HOH O 6 .   ? 33.844  26.165 113.005 1.00 35.24 ? 464 HOH L O   1 
HETATM 3708 O  O   . HOH O 6 .   ? 17.549  31.657 112.205 1.00 37.14 ? 465 HOH L O   1 
HETATM 3709 O  O   . HOH O 6 .   ? 4.314   11.668 105.784 1.00 37.64 ? 466 HOH L O   1 
HETATM 3710 O  O   . HOH O 6 .   ? 29.171  40.973 101.063 1.00 29.33 ? 467 HOH L O   1 
HETATM 3711 O  O   . HOH O 6 .   ? -0.566  15.470 94.092  1.00 32.39 ? 468 HOH L O   1 
HETATM 3712 O  O   . HOH O 6 .   ? 22.924  28.669 92.306  1.00 28.99 ? 469 HOH L O   1 
HETATM 3713 O  O   . HOH O 6 .   ? 25.270  17.530 109.086 1.00 15.12 ? 470 HOH L O   1 
HETATM 3714 O  O   . HOH O 6 .   ? 20.905  19.320 109.802 1.00 18.94 ? 471 HOH L O   1 
HETATM 3715 O  O   . HOH O 6 .   ? 12.485  65.111 108.229 1.00 45.01 ? 472 HOH L O   1 
HETATM 3716 O  O   . HOH O 6 .   ? 24.292  60.572 101.275 1.00 23.83 ? 473 HOH L O   1 
HETATM 3717 O  O   . HOH O 6 .   ? 30.926  32.568 102.176 1.00 20.15 ? 474 HOH L O   1 
HETATM 3718 O  O   . HOH O 6 .   ? 19.722  44.296 108.823 1.00 46.65 ? 475 HOH L O   1 
HETATM 3719 O  O   . HOH O 6 .   ? 34.124  41.525 100.761 1.00 38.21 ? 476 HOH L O   1 
HETATM 3720 O  O   . HOH O 6 .   ? 23.771  14.035 105.578 1.00 16.85 ? 477 HOH L O   1 
HETATM 3721 O  O   . HOH O 6 .   ? 18.526  6.845  94.704  1.00 34.23 ? 478 HOH L O   1 
HETATM 3722 O  O   . HOH O 6 .   ? 8.962   27.567 98.664  1.00 17.08 ? 479 HOH L O   1 
HETATM 3723 O  O   . HOH O 6 .   ? 34.262  63.086 111.033 1.00 45.38 ? 480 HOH L O   1 
HETATM 3724 O  O   . HOH O 6 .   ? 22.461  32.008 102.723 1.00 22.79 ? 481 HOH L O   1 
HETATM 3725 O  O   . HOH O 6 .   ? 5.116   17.864 105.013 1.00 21.29 ? 482 HOH L O   1 
HETATM 3726 O  O   . HOH O 6 .   ? 35.192  22.366 109.540 1.00 23.58 ? 483 HOH L O   1 
HETATM 3727 O  O   . HOH O 6 .   ? 40.200  48.381 102.768 1.00 42.22 ? 484 HOH L O   1 
HETATM 3728 O  O   . HOH O 6 .   ? 32.456  52.867 122.514 1.00 30.97 ? 485 HOH L O   1 
HETATM 3729 O  O   . HOH O 6 .   ? 26.891  41.165 116.233 1.00 23.78 ? 486 HOH L O   1 
HETATM 3730 O  O   . HOH O 6 .   ? 23.703  11.601 100.065 1.00 30.13 ? 487 HOH L O   1 
HETATM 3731 O  O   . HOH O 6 .   ? 14.819  21.957 112.824 1.00 37.60 ? 488 HOH L O   1 
HETATM 3732 O  O   . HOH O 6 .   ? 11.424  18.283 107.743 1.00 27.13 ? 489 HOH L O   1 
HETATM 3733 O  O   . HOH O 6 .   ? 24.550  50.864 118.132 1.00 22.14 ? 490 HOH L O   1 
HETATM 3734 O  O   . HOH O 6 .   ? 22.423  39.043 103.471 1.00 30.84 ? 491 HOH L O   1 
HETATM 3735 O  O   . HOH O 6 .   ? 18.247  10.484 103.437 1.00 20.77 ? 492 HOH L O   1 
HETATM 3736 O  O   . HOH O 6 .   ? 19.045  27.069 86.346  1.00 22.22 ? 493 HOH L O   1 
HETATM 3737 O  O   . HOH O 6 .   ? -1.902  15.308 89.969  1.00 38.72 ? 494 HOH L O   1 
HETATM 3738 O  O   . HOH O 6 .   ? 16.171  55.753 112.716 1.00 30.58 ? 495 HOH L O   1 
HETATM 3739 O  O   . HOH O 6 .   ? 21.739  30.907 88.466  1.00 26.89 ? 496 HOH L O   1 
HETATM 3740 O  O   . HOH O 6 .   ? 1.536   11.142 89.423  1.00 42.12 ? 497 HOH L O   1 
HETATM 3741 O  O   . HOH O 6 .   ? 36.251  22.875 102.646 1.00 30.90 ? 498 HOH L O   1 
HETATM 3742 O  O   . HOH O 6 .   ? 28.446  24.443 90.755  1.00 37.23 ? 499 HOH L O   1 
HETATM 3743 O  O   . HOH O 6 .   ? 37.623  41.911 113.098 1.00 17.82 ? 500 HOH L O   1 
HETATM 3744 O  O   . HOH O 6 .   ? 5.514   23.520 102.745 1.00 28.87 ? 501 HOH L O   1 
HETATM 3745 O  O   . HOH O 6 .   ? 16.057  21.196 103.812 1.00 15.58 ? 502 HOH L O   1 
HETATM 3746 O  O   . HOH O 6 .   ? 30.945  54.885 120.078 1.00 27.01 ? 503 HOH L O   1 
HETATM 3747 O  O   . HOH O 6 .   ? 38.194  31.518 100.323 1.00 36.10 ? 504 HOH L O   1 
HETATM 3748 O  O   . HOH O 6 .   ? 21.188  53.612 100.511 1.00 30.97 ? 505 HOH L O   1 
HETATM 3749 O  O   . HOH O 6 .   ? 10.614  22.727 109.686 1.00 39.74 ? 506 HOH L O   1 
HETATM 3750 O  O   . HOH O 6 .   ? 24.267  21.788 81.446  1.00 26.30 ? 507 HOH L O   1 
HETATM 3751 O  O   . HOH O 6 .   ? 30.883  17.343 80.823  1.00 30.10 ? 508 HOH L O   1 
HETATM 3752 O  O   . HOH O 6 .   ? 19.719  32.943 98.614  1.00 27.89 ? 509 HOH L O   1 
HETATM 3753 O  O   . HOH O 6 .   ? 14.216  7.792  103.351 1.00 28.78 ? 510 HOH L O   1 
HETATM 3754 O  O   . HOH O 6 .   ? 13.365  53.248 110.968 1.00 35.66 ? 511 HOH L O   1 
HETATM 3755 O  O   . HOH O 6 .   ? -4.391  17.025 99.354  1.00 35.43 ? 512 HOH L O   1 
HETATM 3756 O  O   . HOH O 6 .   ? 5.088   22.026 99.943  1.00 20.23 ? 513 HOH L O   1 
HETATM 3757 O  O   . HOH O 6 .   ? 34.161  29.468 111.347 1.00 26.29 ? 514 HOH L O   1 
HETATM 3758 O  O   . HOH O 6 .   ? 21.869  42.836 110.200 1.00 29.23 ? 515 HOH L O   1 
HETATM 3759 O  O   . HOH O 6 .   ? 28.077  26.050 95.509  1.00 18.01 ? 516 HOH L O   1 
HETATM 3760 O  O   . HOH O 6 .   ? 1.049   17.663 94.933  1.00 20.11 ? 517 HOH L O   1 
HETATM 3761 O  O   . HOH O 6 .   ? 32.819  13.313 89.565  1.00 43.65 ? 518 HOH L O   1 
HETATM 3762 O  O   . HOH O 6 .   ? 24.487  33.712 103.594 1.00 22.50 ? 519 HOH L O   1 
HETATM 3763 O  O   . HOH O 6 .   ? 36.313  38.857 98.613  1.00 40.16 ? 520 HOH L O   1 
HETATM 3764 O  O   . HOH O 6 .   ? 28.533  32.644 95.573  1.00 26.23 ? 521 HOH L O   1 
HETATM 3765 O  O   . HOH O 6 .   ? 20.093  51.554 103.331 1.00 33.60 ? 522 HOH L O   1 
HETATM 3766 O  O   . HOH O 6 .   ? 37.549  25.530 102.101 1.00 43.00 ? 523 HOH L O   1 
HETATM 3767 O  O   . HOH O 6 .   ? 11.843  22.407 87.524  1.00 21.37 ? 524 HOH L O   1 
HETATM 3768 O  O   . HOH O 6 .   ? 22.252  71.979 116.943 1.00 33.56 ? 525 HOH L O   1 
HETATM 3769 O  O   . HOH O 6 .   ? 17.090  13.554 98.000  1.00 17.32 ? 526 HOH L O   1 
HETATM 3770 O  O   . HOH O 6 .   ? 30.851  46.033 124.007 1.00 27.19 ? 527 HOH L O   1 
HETATM 3771 O  O   . HOH O 6 .   ? 31.444  40.737 98.282  1.00 33.99 ? 528 HOH L O   1 
HETATM 3772 O  O   . HOH O 6 .   ? -2.212  14.909 96.669  1.00 46.56 ? 529 HOH L O   1 
HETATM 3773 O  O   . HOH O 6 .   ? 36.365  18.477 107.231 1.00 20.71 ? 530 HOH L O   1 
HETATM 3774 O  O   . HOH O 6 .   ? 25.024  11.510 90.009  1.00 26.78 ? 531 HOH L O   1 
HETATM 3775 O  O   . HOH O 6 .   ? 19.386  12.518 108.278 1.00 34.67 ? 532 HOH L O   1 
HETATM 3776 O  O   . HOH O 6 .   ? 24.536  63.151 117.260 1.00 25.90 ? 533 HOH L O   1 
HETATM 3777 O  O   . HOH O 6 .   ? 17.623  41.788 106.192 1.00 58.67 ? 534 HOH L O   1 
HETATM 3778 O  O   . HOH O 6 .   ? 21.167  40.192 100.231 1.00 34.67 ? 535 HOH L O   1 
HETATM 3779 O  O   . HOH O 6 .   ? 21.313  30.833 92.234  1.00 18.52 ? 536 HOH L O   1 
HETATM 3780 O  O   . HOH O 6 .   ? 21.761  12.319 104.935 1.00 20.06 ? 537 HOH L O   1 
HETATM 3781 O  O   . HOH O 6 .   ? 17.930  74.695 115.191 1.00 41.14 ? 538 HOH L O   1 
HETATM 3782 O  O   . HOH O 6 .   ? 28.696  10.065 95.293  1.00 42.36 ? 539 HOH L O   1 
HETATM 3783 O  O   . HOH O 6 .   ? 30.876  14.420 105.273 1.00 17.27 ? 540 HOH L O   1 
HETATM 3784 O  O   . HOH O 6 .   ? 31.300  41.657 102.482 1.00 24.47 ? 541 HOH L O   1 
HETATM 3785 O  O   . HOH O 6 .   ? 34.974  30.376 107.480 1.00 28.74 ? 542 HOH L O   1 
HETATM 3786 O  O   . HOH O 6 .   ? 14.706  63.975 113.270 1.00 57.37 ? 543 HOH L O   1 
HETATM 3787 O  O   . HOH O 6 .   ? 18.295  6.484  99.961  1.00 35.49 ? 544 HOH L O   1 
HETATM 3788 O  O   . HOH O 6 .   ? 31.705  37.348 96.566  1.00 37.51 ? 545 HOH L O   1 
HETATM 3789 O  O   . HOH O 6 .   ? 23.467  32.762 111.461 1.00 36.51 ? 546 HOH L O   1 
HETATM 3790 O  O   . HOH O 6 .   ? 12.737  31.053 101.347 1.00 42.26 ? 547 HOH L O   1 
HETATM 3791 O  O   . HOH O 6 .   ? 37.605  43.328 110.713 1.00 23.35 ? 548 HOH L O   1 
HETATM 3792 O  O   . HOH O 6 .   ? 12.160  70.752 103.882 1.00 40.36 ? 549 HOH L O   1 
HETATM 3793 O  O   . HOH O 6 .   ? 11.911  54.312 107.858 1.00 43.39 ? 550 HOH L O   1 
HETATM 3794 O  O   . HOH O 6 .   ? 14.338  29.949 105.795 1.00 41.30 ? 551 HOH L O   1 
HETATM 3795 O  O   . HOH O 6 .   ? 25.522  11.632 102.274 1.00 29.94 ? 552 HOH L O   1 
HETATM 3796 O  O   . HOH O 6 .   ? 31.961  11.424 90.986  1.00 40.34 ? 553 HOH L O   1 
HETATM 3797 O  O   . HOH O 6 .   ? 14.662  26.023 111.970 1.00 35.86 ? 554 HOH L O   1 
HETATM 3798 O  O   . HOH O 6 .   ? 13.656  29.573 103.309 1.00 35.56 ? 555 HOH L O   1 
HETATM 3799 O  O   . HOH O 6 .   ? 30.834  65.459 114.252 1.00 35.65 ? 556 HOH L O   1 
HETATM 3800 O  O   . HOH O 6 .   ? 33.847  55.556 118.194 1.00 26.06 ? 557 HOH L O   1 
HETATM 3801 O  O   . HOH O 6 .   ? 36.027  45.307 108.153 1.00 25.53 ? 558 HOH L O   1 
HETATM 3802 O  O   . HOH O 6 .   ? 32.266  25.060 93.596  1.00 36.63 ? 559 HOH L O   1 
HETATM 3803 O  O   . HOH O 6 .   ? 18.797  43.194 103.230 1.00 32.50 ? 560 HOH L O   1 
HETATM 3804 O  O   . HOH O 6 .   ? 23.924  35.652 101.661 1.00 22.06 ? 561 HOH L O   1 
HETATM 3805 O  O   . HOH O 6 .   ? 17.797  60.402 122.824 1.00 37.22 ? 562 HOH L O   1 
HETATM 3806 O  O   . HOH O 6 .   ? 15.105  48.568 107.197 1.00 33.55 ? 563 HOH L O   1 
HETATM 3807 O  O   . HOH O 6 .   ? 24.457  41.499 97.377  1.00 38.95 ? 564 HOH L O   1 
HETATM 3808 O  O   . HOH O 6 .   ? 12.521  58.928 106.736 1.00 37.80 ? 565 HOH L O   1 
HETATM 3809 O  O   . HOH O 6 .   ? 7.190   4.574  100.465 1.00 51.84 ? 566 HOH L O   1 
HETATM 3810 O  O   . HOH O 6 .   ? 34.998  45.704 100.163 1.00 34.64 ? 567 HOH L O   1 
HETATM 3811 O  O   . HOH O 6 .   ? 27.847  12.395 89.624  1.00 22.55 ? 568 HOH L O   1 
HETATM 3812 O  O   . HOH O 6 .   ? -2.428  18.581 101.492 1.00 33.75 ? 569 HOH L O   1 
HETATM 3813 O  O   . HOH O 6 .   ? 32.592  67.207 110.178 1.00 30.32 ? 570 HOH L O   1 
HETATM 3814 O  O   . HOH O 6 .   ? 2.497   23.112 99.486  1.00 30.02 ? 571 HOH L O   1 
HETATM 3815 O  O   . HOH O 6 .   ? 35.128  51.856 120.171 1.00 31.36 ? 572 HOH L O   1 
HETATM 3816 O  O   . HOH O 6 .   ? 37.917  44.038 106.339 1.00 34.03 ? 573 HOH L O   1 
HETATM 3817 O  O   . HOH O 6 .   ? 35.151  33.915 116.313 1.00 20.30 ? 574 HOH L O   1 
HETATM 3818 O  O   . HOH O 6 .   ? 33.971  22.865 93.305  1.00 28.34 ? 575 HOH L O   1 
HETATM 3819 O  O   . HOH O 6 .   ? 32.251  13.169 99.509  1.00 33.56 ? 576 HOH L O   1 
HETATM 3820 O  O   . HOH O 6 .   ? 23.441  26.995 85.977  1.00 37.62 ? 577 HOH L O   1 
HETATM 3821 O  O   . HOH O 6 .   ? 36.764  31.683 109.527 1.00 40.17 ? 578 HOH L O   1 
HETATM 3822 O  O   . HOH O 6 .   ? 18.324  54.837 114.585 1.00 27.41 ? 579 HOH L O   1 
HETATM 3823 O  O   . HOH O 6 .   ? 28.982  40.183 98.340  1.00 40.61 ? 580 HOH L O   1 
HETATM 3824 O  O   . HOH O 6 .   ? 31.587  20.491 89.154  1.00 51.38 ? 581 HOH L O   1 
HETATM 3825 O  O   . HOH O 6 .   ? 39.481  50.787 106.308 1.00 43.40 ? 582 HOH L O   1 
HETATM 3826 O  O   . HOH O 6 .   ? 1.929   7.715  101.683 1.00 38.72 ? 583 HOH L O   1 
HETATM 3827 O  O   . HOH O 6 .   ? 37.337  51.479 124.215 1.00 26.04 ? 584 HOH L O   1 
HETATM 3828 O  O   . HOH O 6 .   ? 13.328  60.097 115.544 1.00 37.76 ? 585 HOH L O   1 
HETATM 3829 O  O   . HOH O 6 .   ? 27.108  33.340 113.869 1.00 43.74 ? 586 HOH L O   1 
HETATM 3830 O  O   . HOH O 6 .   ? 12.432  62.288 110.717 1.00 42.34 ? 587 HOH L O   1 
HETATM 3831 O  O   . HOH O 6 .   ? 29.936  46.744 119.904 1.00 22.58 ? 588 HOH L O   1 
HETATM 3832 O  O   . HOH O 6 .   ? 9.626   9.692  107.437 1.00 41.09 ? 589 HOH L O   1 
HETATM 3833 O  O   . HOH O 6 .   ? 15.597  62.892 97.485  1.00 35.52 ? 590 HOH L O   1 
HETATM 3834 O  O   . HOH O 6 .   ? 25.727  52.059 122.832 1.00 49.32 ? 591 HOH L O   1 
HETATM 3835 O  O   . HOH O 6 .   ? 23.651  19.799 109.482 1.00 15.29 ? 592 HOH L O   1 
HETATM 3836 O  O   . HOH O 6 .   ? 15.965  64.781 116.077 1.00 39.16 ? 593 HOH L O   1 
HETATM 3837 O  O   . HOH O 6 .   ? 9.468   6.669  104.005 1.00 33.27 ? 594 HOH L O   1 
HETATM 3838 O  O   . HOH O 6 .   ? 26.775  67.130 95.010  1.00 40.61 ? 595 HOH L O   1 
HETATM 3839 O  O   . HOH O 6 .   ? 11.058  27.130 107.920 1.00 32.08 ? 596 HOH L O   1 
HETATM 3840 O  O   . HOH O 6 .   ? 22.728  54.877 122.377 1.00 51.31 ? 597 HOH L O   1 
HETATM 3841 O  O   . HOH O 6 .   ? 19.722  30.447 113.399 1.00 34.86 ? 598 HOH L O   1 
HETATM 3842 O  O   . HOH O 6 .   ? 13.771  52.462 114.148 1.00 44.24 ? 599 HOH L O   1 
HETATM 3843 O  O   . HOH O 6 .   ? 22.700  72.340 105.296 1.00 45.25 ? 600 HOH L O   1 
HETATM 3844 O  O   . HOH O 6 .   ? 28.729  68.148 105.428 1.00 42.81 ? 601 HOH L O   1 
HETATM 3845 O  O   . HOH O 6 .   ? 22.073  35.268 109.598 1.00 42.71 ? 602 HOH L O   1 
HETATM 3846 O  O   . HOH O 6 .   ? 12.862  23.372 111.246 1.00 43.18 ? 603 HOH L O   1 
HETATM 3847 O  O   . HOH O 6 .   ? 20.293  33.666 85.012  1.00 37.53 ? 604 HOH L O   1 
HETATM 3848 O  O   . HOH O 6 .   ? 13.214  56.086 106.292 1.00 36.35 ? 605 HOH L O   1 
HETATM 3849 O  O   . HOH O 6 .   ? 2.529   25.027 97.526  1.00 31.58 ? 606 HOH L O   1 
HETATM 3850 O  O   . HOH O 6 .   ? 9.532   18.743 109.742 1.00 43.21 ? 607 HOH L O   1 
HETATM 3851 O  O   . HOH O 6 .   ? 29.108  62.200 117.507 1.00 38.76 ? 608 HOH L O   1 
HETATM 3852 O  O   . HOH O 6 .   ? 25.116  9.608  92.013  1.00 36.18 ? 609 HOH L O   1 
HETATM 3853 O  O   . HOH O 6 .   ? 15.855  35.419 95.912  1.00 41.65 ? 610 HOH L O   1 
HETATM 3854 O  O   . HOH O 6 .   ? 20.480  42.499 113.285 1.00 47.09 ? 611 HOH L O   1 
HETATM 3855 O  O   . HOH O 6 .   ? 28.783  28.106 93.834  1.00 26.56 ? 612 HOH L O   1 
HETATM 3856 O  O   . HOH O 6 .   ? 29.057  11.111 97.728  1.00 36.55 ? 613 HOH L O   1 
HETATM 3857 O  O   . HOH O 6 .   ? 27.973  39.493 120.754 1.00 48.28 ? 614 HOH L O   1 
HETATM 3858 O  O   . HOH O 6 .   ? 21.096  33.211 100.854 1.00 30.21 ? 615 HOH L O   1 
HETATM 3859 O  O   . HOH O 6 .   ? 22.203  40.742 97.500  1.00 45.02 ? 616 HOH L O   1 
HETATM 3860 O  O   . HOH O 6 .   ? 10.944  4.911  95.066  1.00 44.38 ? 617 HOH L O   1 
HETATM 3861 O  O   . HOH O 6 .   ? 18.025  33.880 107.973 1.00 45.13 ? 618 HOH L O   1 
HETATM 3862 O  O   . HOH O 6 .   ? 17.477  34.201 98.695  1.00 46.20 ? 619 HOH L O   1 
HETATM 3863 O  O   . HOH O 6 .   ? 22.351  73.525 114.272 1.00 38.31 ? 620 HOH L O   1 
HETATM 3864 O  O   . HOH O 6 .   ? 24.577  34.353 92.154  1.00 46.93 ? 621 HOH L O   1 
HETATM 3865 O  O   . HOH O 6 .   ? 26.951  17.860 80.045  1.00 29.58 ? 622 HOH L O   1 
HETATM 3866 O  O   . HOH O 6 .   ? 39.329  19.505 99.101  1.00 46.97 ? 623 HOH L O   1 
HETATM 3867 O  O   . HOH O 6 .   ? 29.938  10.578 89.677  1.00 27.90 ? 624 HOH L O   1 
HETATM 3868 O  O   . HOH O 6 .   ? 25.912  10.233 94.911  1.00 43.39 ? 625 HOH L O   1 
HETATM 3869 O  O   . HOH O 6 .   ? 37.916  22.137 104.528 1.00 41.78 ? 626 HOH L O   1 
HETATM 3870 O  O   . HOH O 6 .   ? 28.948  24.402 93.399  1.00 26.26 ? 627 HOH L O   1 
HETATM 3871 O  O   . HOH O 6 .   ? 24.815  71.491 104.362 1.00 39.87 ? 628 HOH L O   1 
HETATM 3872 O  O   . HOH O 6 .   ? 18.189  51.579 101.696 1.00 44.40 ? 629 HOH L O   1 
HETATM 3873 O  O   . HOH O 6 .   ? 25.615  67.030 119.918 1.00 44.36 ? 630 HOH L O   1 
HETATM 3874 O  O   . HOH O 6 .   ? 21.810  31.022 110.263 1.00 22.76 ? 631 HOH L O   1 
HETATM 3875 O  O   . HOH O 6 .   ? 37.193  20.633 108.972 1.00 29.89 ? 632 HOH L O   1 
HETATM 3876 O  O   . HOH O 6 .   ? 29.411  30.976 93.770  1.00 28.84 ? 633 HOH L O   1 
HETATM 3877 O  O   . HOH O 6 .   ? 33.917  29.792 114.017 1.00 36.46 ? 634 HOH L O   1 
HETATM 3878 O  O   . HOH O 6 .   ? 9.846   70.893 105.425 1.00 48.79 ? 635 HOH L O   1 
HETATM 3879 O  O   . HOH O 6 .   ? 0.294   8.600  102.841 1.00 58.47 ? 636 HOH L O   1 
HETATM 3880 O  O   . HOH O 6 .   ? 32.634  16.340 88.275  1.00 39.24 ? 637 HOH L O   1 
HETATM 3881 O  O   . HOH O 6 .   ? 32.058  31.111 93.318  1.00 39.55 ? 638 HOH L O   1 
HETATM 3882 O  O   . HOH O 6 .   ? 26.810  62.696 118.427 1.00 36.78 ? 639 HOH L O   1 
HETATM 3883 O  O   . HOH O 6 .   ? 25.790  30.090 91.022  1.00 33.30 ? 640 HOH L O   1 
HETATM 3884 O  O   . HOH O 6 .   ? 27.061  65.127 119.857 1.00 42.74 ? 641 HOH L O   1 
HETATM 3885 O  O   . HOH O 6 .   ? 7.059   27.382 105.994 1.00 50.46 ? 642 HOH L O   1 
HETATM 3886 O  O   . HOH O 6 .   ? 37.643  27.816 103.232 1.00 35.96 ? 643 HOH L O   1 
HETATM 3887 O  O   . HOH O 6 .   ? 0.672   10.252 86.067  1.00 55.43 ? 644 HOH L O   1 
# 
