data_8TG2
# 
_entry.id   8TG2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8TG2         pdb_00008tg2 10.2210/pdb8tg2/pdb 
WWPDB D_1000275892 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8TG2 
_pdbx_database_status.recvd_initial_deposition_date   2023-07-12 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 Fedorov.Roman@mh-hannover.de     Roman     Fedorov ? 'principal investigator/group leader' 0000-0002-5240-4205 
3 Routier.Francoise@mh-hannover.de Francoise Routier ? 'principal investigator/group leader' 0000-0002-7163-0590 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Prakash, O.'    1 ? 
'Fuehring, J.I.' 2 ? 
'Baruch, P.'     3 ? 
'Routier, F.H.'  4 ? 
'Fedorov, R.'    5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;The post-reactive state structures of Leishmania major UDP-sugar pyrophosphorylase provide insights into the product release mechanism
;
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Prakash, O.'    1 ? 
primary 'Fuehring, J.I.' 2 ? 
primary 'Baruch, P.'     3 ? 
primary 'Routier, F.H.'  4 ? 
primary 'Fedorov, R.'    5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'UTP-monosaccharide-1-phosphate uridylyltransferase' 66935.883 1   2.7.7.64 ? ? ? 
2 non-polymer syn "URIDINE-5'-DIPHOSPHATE-GLUCOSE"                     566.302   1   ?        ? ? ? 
3 non-polymer syn 'PYROPHOSPHATE 2-'                                   175.959   2   ?        ? ? ? 
4 water       nat water                                                18.015    209 ?        ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;NPSNSNLQALREELCTPGLDQGHLFEGWPETVDECNERQIALLTDLYMFSNMYPGGVAQYIRNGHELLARESEEVDFAAL
EMPPLIFEAPSLHRRTAERTALENAGTAMLCKTVFVLVAGGLGERLGYSSIKVSLPVETATNTTYLAYYLRWAQRVGGKE
VPFVIMTSDDTHDRTLQLLRELQLEVPNLHVLKQGQVFCFADSAAHLALDETGKLLRKPHGHGDVHSLIYNATVKRDVVP
DSGDGTATAQPLVNDWLAAGYESIVFIQDTNAGATITIPISLALSAEHSLDMNFTCIPRVPKEPIGLLCRTKKNSGDPWL
VANVEYNVFAEVSRALNKDGGDEVSDPTGFSPFPGSVNTLVFKLSSYVDRLRESHGIVPEFINPKYSDETRRSFKKPARI
ESLMQDIALLFSEDDYRVGGTVFERFSYQPVKNSLEEAAGLVAQGNGAYCAATGEAAFYELQRRRLKAIGLPLFYSSQPE
VTVAKDAFGVRLFPIIVLDTVCASSGSLDDLARVFPTPEKVHIDQHSTLIVEGRVIIESLELYGALTIRGPTDSMALPHV
VRNAVVRNAGWSVHAILSLCAGRDSRLSEVDRIRGFVLKKTAMAVMDC
;
_entity_poly.pdbx_seq_one_letter_code_can   
;NPSNSNLQALREELCTPGLDQGHLFEGWPETVDECNERQIALLTDLYMFSNMYPGGVAQYIRNGHELLARESEEVDFAAL
EMPPLIFEAPSLHRRTAERTALENAGTAMLCKTVFVLVAGGLGERLGYSSIKVSLPVETATNTTYLAYYLRWAQRVGGKE
VPFVIMTSDDTHDRTLQLLRELQLEVPNLHVLKQGQVFCFADSAAHLALDETGKLLRKPHGHGDVHSLIYNATVKRDVVP
DSGDGTATAQPLVNDWLAAGYESIVFIQDTNAGATITIPISLALSAEHSLDMNFTCIPRVPKEPIGLLCRTKKNSGDPWL
VANVEYNVFAEVSRALNKDGGDEVSDPTGFSPFPGSVNTLVFKLSSYVDRLRESHGIVPEFINPKYSDETRRSFKKPARI
ESLMQDIALLFSEDDYRVGGTVFERFSYQPVKNSLEEAAGLVAQGNGAYCAATGEAAFYELQRRRLKAIGLPLFYSSQPE
VTVAKDAFGVRLFPIIVLDTVCASSGSLDDLARVFPTPEKVHIDQHSTLIVEGRVIIESLELYGALTIRGPTDSMALPHV
VRNAVVRNAGWSVHAILSLCAGRDSRLSEVDRIRGFVLKKTAMAVMDC
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "URIDINE-5'-DIPHOSPHATE-GLUCOSE" UPG 
3 'PYROPHOSPHATE 2-'               POP 
4 water                            HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASN n 
1 2   PRO n 
1 3   SER n 
1 4   ASN n 
1 5   SER n 
1 6   ASN n 
1 7   LEU n 
1 8   GLN n 
1 9   ALA n 
1 10  LEU n 
1 11  ARG n 
1 12  GLU n 
1 13  GLU n 
1 14  LEU n 
1 15  CYS n 
1 16  THR n 
1 17  PRO n 
1 18  GLY n 
1 19  LEU n 
1 20  ASP n 
1 21  GLN n 
1 22  GLY n 
1 23  HIS n 
1 24  LEU n 
1 25  PHE n 
1 26  GLU n 
1 27  GLY n 
1 28  TRP n 
1 29  PRO n 
1 30  GLU n 
1 31  THR n 
1 32  VAL n 
1 33  ASP n 
1 34  GLU n 
1 35  CYS n 
1 36  ASN n 
1 37  GLU n 
1 38  ARG n 
1 39  GLN n 
1 40  ILE n 
1 41  ALA n 
1 42  LEU n 
1 43  LEU n 
1 44  THR n 
1 45  ASP n 
1 46  LEU n 
1 47  TYR n 
1 48  MET n 
1 49  PHE n 
1 50  SER n 
1 51  ASN n 
1 52  MET n 
1 53  TYR n 
1 54  PRO n 
1 55  GLY n 
1 56  GLY n 
1 57  VAL n 
1 58  ALA n 
1 59  GLN n 
1 60  TYR n 
1 61  ILE n 
1 62  ARG n 
1 63  ASN n 
1 64  GLY n 
1 65  HIS n 
1 66  GLU n 
1 67  LEU n 
1 68  LEU n 
1 69  ALA n 
1 70  ARG n 
1 71  GLU n 
1 72  SER n 
1 73  GLU n 
1 74  GLU n 
1 75  VAL n 
1 76  ASP n 
1 77  PHE n 
1 78  ALA n 
1 79  ALA n 
1 80  LEU n 
1 81  GLU n 
1 82  MET n 
1 83  PRO n 
1 84  PRO n 
1 85  LEU n 
1 86  ILE n 
1 87  PHE n 
1 88  GLU n 
1 89  ALA n 
1 90  PRO n 
1 91  SER n 
1 92  LEU n 
1 93  HIS n 
1 94  ARG n 
1 95  ARG n 
1 96  THR n 
1 97  ALA n 
1 98  GLU n 
1 99  ARG n 
1 100 THR n 
1 101 ALA n 
1 102 LEU n 
1 103 GLU n 
1 104 ASN n 
1 105 ALA n 
1 106 GLY n 
1 107 THR n 
1 108 ALA n 
1 109 MET n 
1 110 LEU n 
1 111 CYS n 
1 112 LYS n 
1 113 THR n 
1 114 VAL n 
1 115 PHE n 
1 116 VAL n 
1 117 LEU n 
1 118 VAL n 
1 119 ALA n 
1 120 GLY n 
1 121 GLY n 
1 122 LEU n 
1 123 GLY n 
1 124 GLU n 
1 125 ARG n 
1 126 LEU n 
1 127 GLY n 
1 128 TYR n 
1 129 SER n 
1 130 SER n 
1 131 ILE n 
1 132 LYS n 
1 133 VAL n 
1 134 SER n 
1 135 LEU n 
1 136 PRO n 
1 137 VAL n 
1 138 GLU n 
1 139 THR n 
1 140 ALA n 
1 141 THR n 
1 142 ASN n 
1 143 THR n 
1 144 THR n 
1 145 TYR n 
1 146 LEU n 
1 147 ALA n 
1 148 TYR n 
1 149 TYR n 
1 150 LEU n 
1 151 ARG n 
1 152 TRP n 
1 153 ALA n 
1 154 GLN n 
1 155 ARG n 
1 156 VAL n 
1 157 GLY n 
1 158 GLY n 
1 159 LYS n 
1 160 GLU n 
1 161 VAL n 
1 162 PRO n 
1 163 PHE n 
1 164 VAL n 
1 165 ILE n 
1 166 MET n 
1 167 THR n 
1 168 SER n 
1 169 ASP n 
1 170 ASP n 
1 171 THR n 
1 172 HIS n 
1 173 ASP n 
1 174 ARG n 
1 175 THR n 
1 176 LEU n 
1 177 GLN n 
1 178 LEU n 
1 179 LEU n 
1 180 ARG n 
1 181 GLU n 
1 182 LEU n 
1 183 GLN n 
1 184 LEU n 
1 185 GLU n 
1 186 VAL n 
1 187 PRO n 
1 188 ASN n 
1 189 LEU n 
1 190 HIS n 
1 191 VAL n 
1 192 LEU n 
1 193 LYS n 
1 194 GLN n 
1 195 GLY n 
1 196 GLN n 
1 197 VAL n 
1 198 PHE n 
1 199 CYS n 
1 200 PHE n 
1 201 ALA n 
1 202 ASP n 
1 203 SER n 
1 204 ALA n 
1 205 ALA n 
1 206 HIS n 
1 207 LEU n 
1 208 ALA n 
1 209 LEU n 
1 210 ASP n 
1 211 GLU n 
1 212 THR n 
1 213 GLY n 
1 214 LYS n 
1 215 LEU n 
1 216 LEU n 
1 217 ARG n 
1 218 LYS n 
1 219 PRO n 
1 220 HIS n 
1 221 GLY n 
1 222 HIS n 
1 223 GLY n 
1 224 ASP n 
1 225 VAL n 
1 226 HIS n 
1 227 SER n 
1 228 LEU n 
1 229 ILE n 
1 230 TYR n 
1 231 ASN n 
1 232 ALA n 
1 233 THR n 
1 234 VAL n 
1 235 LYS n 
1 236 ARG n 
1 237 ASP n 
1 238 VAL n 
1 239 VAL n 
1 240 PRO n 
1 241 ASP n 
1 242 SER n 
1 243 GLY n 
1 244 ASP n 
1 245 GLY n 
1 246 THR n 
1 247 ALA n 
1 248 THR n 
1 249 ALA n 
1 250 GLN n 
1 251 PRO n 
1 252 LEU n 
1 253 VAL n 
1 254 ASN n 
1 255 ASP n 
1 256 TRP n 
1 257 LEU n 
1 258 ALA n 
1 259 ALA n 
1 260 GLY n 
1 261 TYR n 
1 262 GLU n 
1 263 SER n 
1 264 ILE n 
1 265 VAL n 
1 266 PHE n 
1 267 ILE n 
1 268 GLN n 
1 269 ASP n 
1 270 THR n 
1 271 ASN n 
1 272 ALA n 
1 273 GLY n 
1 274 ALA n 
1 275 THR n 
1 276 ILE n 
1 277 THR n 
1 278 ILE n 
1 279 PRO n 
1 280 ILE n 
1 281 SER n 
1 282 LEU n 
1 283 ALA n 
1 284 LEU n 
1 285 SER n 
1 286 ALA n 
1 287 GLU n 
1 288 HIS n 
1 289 SER n 
1 290 LEU n 
1 291 ASP n 
1 292 MET n 
1 293 ASN n 
1 294 PHE n 
1 295 THR n 
1 296 CYS n 
1 297 ILE n 
1 298 PRO n 
1 299 ARG n 
1 300 VAL n 
1 301 PRO n 
1 302 LYS n 
1 303 GLU n 
1 304 PRO n 
1 305 ILE n 
1 306 GLY n 
1 307 LEU n 
1 308 LEU n 
1 309 CYS n 
1 310 ARG n 
1 311 THR n 
1 312 LYS n 
1 313 LYS n 
1 314 ASN n 
1 315 SER n 
1 316 GLY n 
1 317 ASP n 
1 318 PRO n 
1 319 TRP n 
1 320 LEU n 
1 321 VAL n 
1 322 ALA n 
1 323 ASN n 
1 324 VAL n 
1 325 GLU n 
1 326 TYR n 
1 327 ASN n 
1 328 VAL n 
1 329 PHE n 
1 330 ALA n 
1 331 GLU n 
1 332 VAL n 
1 333 SER n 
1 334 ARG n 
1 335 ALA n 
1 336 LEU n 
1 337 ASN n 
1 338 LYS n 
1 339 ASP n 
1 340 GLY n 
1 341 GLY n 
1 342 ASP n 
1 343 GLU n 
1 344 VAL n 
1 345 SER n 
1 346 ASP n 
1 347 PRO n 
1 348 THR n 
1 349 GLY n 
1 350 PHE n 
1 351 SER n 
1 352 PRO n 
1 353 PHE n 
1 354 PRO n 
1 355 GLY n 
1 356 SER n 
1 357 VAL n 
1 358 ASN n 
1 359 THR n 
1 360 LEU n 
1 361 VAL n 
1 362 PHE n 
1 363 LYS n 
1 364 LEU n 
1 365 SER n 
1 366 SER n 
1 367 TYR n 
1 368 VAL n 
1 369 ASP n 
1 370 ARG n 
1 371 LEU n 
1 372 ARG n 
1 373 GLU n 
1 374 SER n 
1 375 HIS n 
1 376 GLY n 
1 377 ILE n 
1 378 VAL n 
1 379 PRO n 
1 380 GLU n 
1 381 PHE n 
1 382 ILE n 
1 383 ASN n 
1 384 PRO n 
1 385 LYS n 
1 386 TYR n 
1 387 SER n 
1 388 ASP n 
1 389 GLU n 
1 390 THR n 
1 391 ARG n 
1 392 ARG n 
1 393 SER n 
1 394 PHE n 
1 395 LYS n 
1 396 LYS n 
1 397 PRO n 
1 398 ALA n 
1 399 ARG n 
1 400 ILE n 
1 401 GLU n 
1 402 SER n 
1 403 LEU n 
1 404 MET n 
1 405 GLN n 
1 406 ASP n 
1 407 ILE n 
1 408 ALA n 
1 409 LEU n 
1 410 LEU n 
1 411 PHE n 
1 412 SER n 
1 413 GLU n 
1 414 ASP n 
1 415 ASP n 
1 416 TYR n 
1 417 ARG n 
1 418 VAL n 
1 419 GLY n 
1 420 GLY n 
1 421 THR n 
1 422 VAL n 
1 423 PHE n 
1 424 GLU n 
1 425 ARG n 
1 426 PHE n 
1 427 SER n 
1 428 TYR n 
1 429 GLN n 
1 430 PRO n 
1 431 VAL n 
1 432 LYS n 
1 433 ASN n 
1 434 SER n 
1 435 LEU n 
1 436 GLU n 
1 437 GLU n 
1 438 ALA n 
1 439 ALA n 
1 440 GLY n 
1 441 LEU n 
1 442 VAL n 
1 443 ALA n 
1 444 GLN n 
1 445 GLY n 
1 446 ASN n 
1 447 GLY n 
1 448 ALA n 
1 449 TYR n 
1 450 CYS n 
1 451 ALA n 
1 452 ALA n 
1 453 THR n 
1 454 GLY n 
1 455 GLU n 
1 456 ALA n 
1 457 ALA n 
1 458 PHE n 
1 459 TYR n 
1 460 GLU n 
1 461 LEU n 
1 462 GLN n 
1 463 ARG n 
1 464 ARG n 
1 465 ARG n 
1 466 LEU n 
1 467 LYS n 
1 468 ALA n 
1 469 ILE n 
1 470 GLY n 
1 471 LEU n 
1 472 PRO n 
1 473 LEU n 
1 474 PHE n 
1 475 TYR n 
1 476 SER n 
1 477 SER n 
1 478 GLN n 
1 479 PRO n 
1 480 GLU n 
1 481 VAL n 
1 482 THR n 
1 483 VAL n 
1 484 ALA n 
1 485 LYS n 
1 486 ASP n 
1 487 ALA n 
1 488 PHE n 
1 489 GLY n 
1 490 VAL n 
1 491 ARG n 
1 492 LEU n 
1 493 PHE n 
1 494 PRO n 
1 495 ILE n 
1 496 ILE n 
1 497 VAL n 
1 498 LEU n 
1 499 ASP n 
1 500 THR n 
1 501 VAL n 
1 502 CYS n 
1 503 ALA n 
1 504 SER n 
1 505 SER n 
1 506 GLY n 
1 507 SER n 
1 508 LEU n 
1 509 ASP n 
1 510 ASP n 
1 511 LEU n 
1 512 ALA n 
1 513 ARG n 
1 514 VAL n 
1 515 PHE n 
1 516 PRO n 
1 517 THR n 
1 518 PRO n 
1 519 GLU n 
1 520 LYS n 
1 521 VAL n 
1 522 HIS n 
1 523 ILE n 
1 524 ASP n 
1 525 GLN n 
1 526 HIS n 
1 527 SER n 
1 528 THR n 
1 529 LEU n 
1 530 ILE n 
1 531 VAL n 
1 532 GLU n 
1 533 GLY n 
1 534 ARG n 
1 535 VAL n 
1 536 ILE n 
1 537 ILE n 
1 538 GLU n 
1 539 SER n 
1 540 LEU n 
1 541 GLU n 
1 542 LEU n 
1 543 TYR n 
1 544 GLY n 
1 545 ALA n 
1 546 LEU n 
1 547 THR n 
1 548 ILE n 
1 549 ARG n 
1 550 GLY n 
1 551 PRO n 
1 552 THR n 
1 553 ASP n 
1 554 SER n 
1 555 MET n 
1 556 ALA n 
1 557 LEU n 
1 558 PRO n 
1 559 HIS n 
1 560 VAL n 
1 561 VAL n 
1 562 ARG n 
1 563 ASN n 
1 564 ALA n 
1 565 VAL n 
1 566 VAL n 
1 567 ARG n 
1 568 ASN n 
1 569 ALA n 
1 570 GLY n 
1 571 TRP n 
1 572 SER n 
1 573 VAL n 
1 574 HIS n 
1 575 ALA n 
1 576 ILE n 
1 577 LEU n 
1 578 SER n 
1 579 LEU n 
1 580 CYS n 
1 581 ALA n 
1 582 GLY n 
1 583 ARG n 
1 584 ASP n 
1 585 SER n 
1 586 ARG n 
1 587 LEU n 
1 588 SER n 
1 589 GLU n 
1 590 VAL n 
1 591 ASP n 
1 592 ARG n 
1 593 ILE n 
1 594 ARG n 
1 595 GLY n 
1 596 PHE n 
1 597 VAL n 
1 598 LEU n 
1 599 LYS n 
1 600 LYS n 
1 601 THR n 
1 602 ALA n 
1 603 MET n 
1 604 ALA n 
1 605 VAL n 
1 606 MET n 
1 607 ASP n 
1 608 CYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   608 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 USP 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Leishmania major' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     5664 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                          ?                                                             
'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                         ?                                                             
'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                       ?                                                             
'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                  ?                                                             
'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                         ?                                                             
'C3 H7 N O2 S'      121.158 
GLN 'L-peptide linking' y GLUTAMINE                        ?                                                             
'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                  ?                                                             
'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                          ?                                                             
'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                        ?                                                             
'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                            ?                                                             'H2 O' 
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                       ?                                                             
'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                          ?                                                             
'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                           ?                                                             
'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                       ?                                                             
'C5 H11 N O2 S'     149.211 
PHE 'L-peptide linking' y PHENYLALANINE                    ?                                                             
'C9 H11 N O2'       165.189 
POP non-polymer         . 'PYROPHOSPHATE 2-'               ?                                                             
'H2 O7 P2 -2'       175.959 
PRO 'L-peptide linking' y PROLINE                          ?                                                             
'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                           ?                                                             
'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                        ?                                                             
'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                       ?                                                             
'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                         ?                                                             
'C9 H11 N O3'       181.189 
UPG non-polymer         . "URIDINE-5'-DIPHOSPHATE-GLUCOSE" 
;URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER
;
'C15 H24 N2 O17 P2' 566.302 
VAL 'L-peptide linking' y VALINE                           ?                                                             
'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASN 1   3   3   ASN ASN A . n 
A 1 2   PRO 2   4   4   PRO PRO A . n 
A 1 3   SER 3   5   5   SER SER A . n 
A 1 4   ASN 4   6   6   ASN ASN A . n 
A 1 5   SER 5   7   7   SER SER A . n 
A 1 6   ASN 6   8   8   ASN ASN A . n 
A 1 7   LEU 7   9   9   LEU LEU A . n 
A 1 8   GLN 8   10  10  GLN GLN A . n 
A 1 9   ALA 9   11  11  ALA ALA A . n 
A 1 10  LEU 10  12  12  LEU LEU A . n 
A 1 11  ARG 11  13  13  ARG ARG A . n 
A 1 12  GLU 12  14  14  GLU GLU A . n 
A 1 13  GLU 13  15  15  GLU GLU A . n 
A 1 14  LEU 14  16  16  LEU LEU A . n 
A 1 15  CYS 15  17  17  CYS CYS A . n 
A 1 16  THR 16  18  18  THR THR A . n 
A 1 17  PRO 17  19  19  PRO PRO A . n 
A 1 18  GLY 18  20  20  GLY GLY A . n 
A 1 19  LEU 19  21  21  LEU LEU A . n 
A 1 20  ASP 20  22  22  ASP ASP A . n 
A 1 21  GLN 21  23  23  GLN GLN A . n 
A 1 22  GLY 22  24  24  GLY GLY A . n 
A 1 23  HIS 23  25  25  HIS HIS A . n 
A 1 24  LEU 24  26  26  LEU LEU A . n 
A 1 25  PHE 25  27  27  PHE PHE A . n 
A 1 26  GLU 26  28  28  GLU GLU A . n 
A 1 27  GLY 27  29  29  GLY GLY A . n 
A 1 28  TRP 28  30  30  TRP TRP A . n 
A 1 29  PRO 29  31  31  PRO PRO A . n 
A 1 30  GLU 30  32  32  GLU GLU A . n 
A 1 31  THR 31  33  33  THR THR A . n 
A 1 32  VAL 32  34  34  VAL VAL A . n 
A 1 33  ASP 33  35  35  ASP ASP A . n 
A 1 34  GLU 34  36  36  GLU GLU A . n 
A 1 35  CYS 35  37  37  CYS CYS A . n 
A 1 36  ASN 36  38  38  ASN ASN A . n 
A 1 37  GLU 37  39  39  GLU GLU A . n 
A 1 38  ARG 38  40  40  ARG ARG A . n 
A 1 39  GLN 39  41  41  GLN GLN A . n 
A 1 40  ILE 40  42  42  ILE ILE A . n 
A 1 41  ALA 41  43  43  ALA ALA A . n 
A 1 42  LEU 42  44  44  LEU LEU A . n 
A 1 43  LEU 43  45  45  LEU LEU A . n 
A 1 44  THR 44  46  46  THR THR A . n 
A 1 45  ASP 45  47  47  ASP ASP A . n 
A 1 46  LEU 46  48  48  LEU LEU A . n 
A 1 47  TYR 47  49  49  TYR TYR A . n 
A 1 48  MET 48  50  50  MET MET A . n 
A 1 49  PHE 49  51  51  PHE PHE A . n 
A 1 50  SER 50  52  52  SER SER A . n 
A 1 51  ASN 51  53  53  ASN ASN A . n 
A 1 52  MET 52  54  54  MET MET A . n 
A 1 53  TYR 53  55  55  TYR TYR A . n 
A 1 54  PRO 54  56  56  PRO PRO A . n 
A 1 55  GLY 55  57  57  GLY GLY A . n 
A 1 56  GLY 56  58  58  GLY GLY A . n 
A 1 57  VAL 57  59  59  VAL VAL A . n 
A 1 58  ALA 58  60  60  ALA ALA A . n 
A 1 59  GLN 59  61  61  GLN GLN A . n 
A 1 60  TYR 60  62  62  TYR TYR A . n 
A 1 61  ILE 61  63  63  ILE ILE A . n 
A 1 62  ARG 62  64  64  ARG ARG A . n 
A 1 63  ASN 63  65  65  ASN ASN A . n 
A 1 64  GLY 64  66  66  GLY GLY A . n 
A 1 65  HIS 65  67  67  HIS HIS A . n 
A 1 66  GLU 66  68  68  GLU GLU A . n 
A 1 67  LEU 67  69  69  LEU LEU A . n 
A 1 68  LEU 68  70  70  LEU LEU A . n 
A 1 69  ALA 69  71  71  ALA ALA A . n 
A 1 70  ARG 70  72  72  ARG ARG A . n 
A 1 71  GLU 71  73  73  GLU GLU A . n 
A 1 72  SER 72  74  74  SER SER A . n 
A 1 73  GLU 73  75  75  GLU GLU A . n 
A 1 74  GLU 74  76  76  GLU GLU A . n 
A 1 75  VAL 75  77  77  VAL VAL A . n 
A 1 76  ASP 76  78  78  ASP ASP A . n 
A 1 77  PHE 77  79  79  PHE PHE A . n 
A 1 78  ALA 78  80  80  ALA ALA A . n 
A 1 79  ALA 79  81  81  ALA ALA A . n 
A 1 80  LEU 80  82  82  LEU LEU A . n 
A 1 81  GLU 81  83  83  GLU GLU A . n 
A 1 82  MET 82  84  84  MET MET A . n 
A 1 83  PRO 83  85  85  PRO PRO A . n 
A 1 84  PRO 84  86  86  PRO PRO A . n 
A 1 85  LEU 85  87  87  LEU LEU A . n 
A 1 86  ILE 86  88  88  ILE ILE A . n 
A 1 87  PHE 87  89  89  PHE PHE A . n 
A 1 88  GLU 88  90  90  GLU GLU A . n 
A 1 89  ALA 89  91  91  ALA ALA A . n 
A 1 90  PRO 90  92  92  PRO PRO A . n 
A 1 91  SER 91  93  93  SER SER A . n 
A 1 92  LEU 92  94  94  LEU LEU A . n 
A 1 93  HIS 93  95  95  HIS HIS A . n 
A 1 94  ARG 94  96  96  ARG ARG A . n 
A 1 95  ARG 95  97  97  ARG ARG A . n 
A 1 96  THR 96  98  98  THR THR A . n 
A 1 97  ALA 97  99  99  ALA ALA A . n 
A 1 98  GLU 98  100 100 GLU GLU A . n 
A 1 99  ARG 99  101 101 ARG ARG A . n 
A 1 100 THR 100 102 102 THR THR A . n 
A 1 101 ALA 101 103 103 ALA ALA A . n 
A 1 102 LEU 102 104 104 LEU LEU A . n 
A 1 103 GLU 103 105 105 GLU GLU A . n 
A 1 104 ASN 104 106 106 ASN ASN A . n 
A 1 105 ALA 105 107 107 ALA ALA A . n 
A 1 106 GLY 106 108 108 GLY GLY A . n 
A 1 107 THR 107 109 109 THR THR A . n 
A 1 108 ALA 108 110 110 ALA ALA A . n 
A 1 109 MET 109 111 111 MET MET A . n 
A 1 110 LEU 110 112 112 LEU LEU A . n 
A 1 111 CYS 111 113 113 CYS CYS A . n 
A 1 112 LYS 112 114 114 LYS LYS A . n 
A 1 113 THR 113 115 115 THR THR A . n 
A 1 114 VAL 114 116 116 VAL VAL A . n 
A 1 115 PHE 115 117 117 PHE PHE A . n 
A 1 116 VAL 116 118 118 VAL VAL A . n 
A 1 117 LEU 117 119 119 LEU LEU A . n 
A 1 118 VAL 118 120 120 VAL VAL A . n 
A 1 119 ALA 119 121 121 ALA ALA A . n 
A 1 120 GLY 120 122 122 GLY GLY A . n 
A 1 121 GLY 121 123 123 GLY GLY A . n 
A 1 122 LEU 122 124 124 LEU LEU A . n 
A 1 123 GLY 123 125 125 GLY GLY A . n 
A 1 124 GLU 124 126 126 GLU GLU A . n 
A 1 125 ARG 125 127 127 ARG ARG A . n 
A 1 126 LEU 126 128 128 LEU LEU A . n 
A 1 127 GLY 127 129 129 GLY GLY A . n 
A 1 128 TYR 128 130 130 TYR TYR A . n 
A 1 129 SER 129 131 131 SER SER A . n 
A 1 130 SER 130 132 132 SER SER A . n 
A 1 131 ILE 131 133 133 ILE ILE A . n 
A 1 132 LYS 132 134 134 LYS LYS A . n 
A 1 133 VAL 133 135 135 VAL VAL A . n 
A 1 134 SER 134 136 136 SER SER A . n 
A 1 135 LEU 135 137 137 LEU LEU A . n 
A 1 136 PRO 136 138 138 PRO PRO A . n 
A 1 137 VAL 137 139 139 VAL VAL A . n 
A 1 138 GLU 138 140 140 GLU GLU A . n 
A 1 139 THR 139 141 141 THR THR A . n 
A 1 140 ALA 140 142 142 ALA ALA A . n 
A 1 141 THR 141 143 143 THR THR A . n 
A 1 142 ASN 142 144 144 ASN ASN A . n 
A 1 143 THR 143 145 145 THR THR A . n 
A 1 144 THR 144 146 146 THR THR A . n 
A 1 145 TYR 145 147 147 TYR TYR A . n 
A 1 146 LEU 146 148 148 LEU LEU A . n 
A 1 147 ALA 147 149 149 ALA ALA A . n 
A 1 148 TYR 148 150 150 TYR TYR A . n 
A 1 149 TYR 149 151 151 TYR TYR A . n 
A 1 150 LEU 150 152 152 LEU LEU A . n 
A 1 151 ARG 151 153 153 ARG ARG A . n 
A 1 152 TRP 152 154 154 TRP TRP A . n 
A 1 153 ALA 153 155 155 ALA ALA A . n 
A 1 154 GLN 154 156 156 GLN GLN A . n 
A 1 155 ARG 155 157 157 ARG ARG A . n 
A 1 156 VAL 156 158 158 VAL VAL A . n 
A 1 157 GLY 157 159 159 GLY GLY A . n 
A 1 158 GLY 158 160 160 GLY GLY A . n 
A 1 159 LYS 159 161 161 LYS LYS A . n 
A 1 160 GLU 160 162 162 GLU GLU A . n 
A 1 161 VAL 161 163 163 VAL VAL A . n 
A 1 162 PRO 162 164 164 PRO PRO A . n 
A 1 163 PHE 163 165 165 PHE PHE A . n 
A 1 164 VAL 164 166 166 VAL VAL A . n 
A 1 165 ILE 165 167 167 ILE ILE A . n 
A 1 166 MET 166 168 168 MET MET A . n 
A 1 167 THR 167 169 169 THR THR A . n 
A 1 168 SER 168 170 170 SER SER A . n 
A 1 169 ASP 169 171 171 ASP ASP A . n 
A 1 170 ASP 170 172 172 ASP ASP A . n 
A 1 171 THR 171 173 173 THR THR A . n 
A 1 172 HIS 172 174 174 HIS HIS A . n 
A 1 173 ASP 173 175 175 ASP ASP A . n 
A 1 174 ARG 174 176 176 ARG ARG A . n 
A 1 175 THR 175 177 177 THR THR A . n 
A 1 176 LEU 176 178 178 LEU LEU A . n 
A 1 177 GLN 177 179 179 GLN GLN A . n 
A 1 178 LEU 178 180 180 LEU LEU A . n 
A 1 179 LEU 179 181 181 LEU LEU A . n 
A 1 180 ARG 180 182 182 ARG ARG A . n 
A 1 181 GLU 181 183 183 GLU GLU A . n 
A 1 182 LEU 182 184 184 LEU LEU A . n 
A 1 183 GLN 183 185 185 GLN GLN A . n 
A 1 184 LEU 184 186 186 LEU LEU A . n 
A 1 185 GLU 185 187 187 GLU GLU A . n 
A 1 186 VAL 186 188 188 VAL VAL A . n 
A 1 187 PRO 187 189 189 PRO PRO A . n 
A 1 188 ASN 188 190 190 ASN ASN A . n 
A 1 189 LEU 189 191 191 LEU LEU A . n 
A 1 190 HIS 190 192 192 HIS HIS A . n 
A 1 191 VAL 191 193 193 VAL VAL A . n 
A 1 192 LEU 192 194 194 LEU LEU A . n 
A 1 193 LYS 193 195 195 LYS LYS A . n 
A 1 194 GLN 194 196 196 GLN GLN A . n 
A 1 195 GLY 195 197 197 GLY GLY A . n 
A 1 196 GLN 196 198 198 GLN GLN A . n 
A 1 197 VAL 197 199 199 VAL VAL A . n 
A 1 198 PHE 198 200 200 PHE PHE A . n 
A 1 199 CYS 199 201 201 CYS CYS A . n 
A 1 200 PHE 200 202 202 PHE PHE A . n 
A 1 201 ALA 201 203 203 ALA ALA A . n 
A 1 202 ASP 202 204 204 ASP ASP A . n 
A 1 203 SER 203 205 205 SER SER A . n 
A 1 204 ALA 204 206 206 ALA ALA A . n 
A 1 205 ALA 205 207 207 ALA ALA A . n 
A 1 206 HIS 206 208 208 HIS HIS A . n 
A 1 207 LEU 207 209 209 LEU LEU A . n 
A 1 208 ALA 208 210 210 ALA ALA A . n 
A 1 209 LEU 209 211 211 LEU LEU A . n 
A 1 210 ASP 210 212 212 ASP ASP A . n 
A 1 211 GLU 211 213 213 GLU GLU A . n 
A 1 212 THR 212 214 214 THR THR A . n 
A 1 213 GLY 213 215 215 GLY GLY A . n 
A 1 214 LYS 214 216 216 LYS LYS A . n 
A 1 215 LEU 215 217 217 LEU LEU A . n 
A 1 216 LEU 216 218 218 LEU LEU A . n 
A 1 217 ARG 217 219 219 ARG ARG A . n 
A 1 218 LYS 218 220 220 LYS LYS A . n 
A 1 219 PRO 219 221 221 PRO PRO A . n 
A 1 220 HIS 220 222 222 HIS HIS A . n 
A 1 221 GLY 221 223 223 GLY GLY A . n 
A 1 222 HIS 222 224 224 HIS HIS A . n 
A 1 223 GLY 223 225 225 GLY GLY A . n 
A 1 224 ASP 224 226 226 ASP ASP A . n 
A 1 225 VAL 225 227 227 VAL VAL A . n 
A 1 226 HIS 226 228 228 HIS HIS A . n 
A 1 227 SER 227 229 229 SER SER A . n 
A 1 228 LEU 228 230 230 LEU LEU A . n 
A 1 229 ILE 229 231 231 ILE ILE A . n 
A 1 230 TYR 230 232 232 TYR TYR A . n 
A 1 231 ASN 231 233 233 ASN ASN A . n 
A 1 232 ALA 232 234 234 ALA ALA A . n 
A 1 233 THR 233 235 235 THR THR A . n 
A 1 234 VAL 234 236 236 VAL VAL A . n 
A 1 235 LYS 235 237 237 LYS LYS A . n 
A 1 236 ARG 236 238 238 ARG ARG A . n 
A 1 237 ASP 237 239 239 ASP ASP A . n 
A 1 238 VAL 238 240 240 VAL VAL A . n 
A 1 239 VAL 239 241 241 VAL VAL A . n 
A 1 240 PRO 240 242 242 PRO PRO A . n 
A 1 241 ASP 241 243 243 ASP ASP A . n 
A 1 242 SER 242 244 244 SER SER A . n 
A 1 243 GLY 243 245 245 GLY GLY A . n 
A 1 244 ASP 244 246 246 ASP ASP A . n 
A 1 245 GLY 245 247 247 GLY GLY A . n 
A 1 246 THR 246 248 248 THR THR A . n 
A 1 247 ALA 247 249 249 ALA ALA A . n 
A 1 248 THR 248 250 250 THR THR A . n 
A 1 249 ALA 249 251 251 ALA ALA A . n 
A 1 250 GLN 250 252 252 GLN GLN A . n 
A 1 251 PRO 251 253 253 PRO PRO A . n 
A 1 252 LEU 252 254 254 LEU LEU A . n 
A 1 253 VAL 253 255 255 VAL VAL A . n 
A 1 254 ASN 254 256 256 ASN ASN A . n 
A 1 255 ASP 255 257 257 ASP ASP A . n 
A 1 256 TRP 256 258 258 TRP TRP A . n 
A 1 257 LEU 257 259 259 LEU LEU A . n 
A 1 258 ALA 258 260 260 ALA ALA A . n 
A 1 259 ALA 259 261 261 ALA ALA A . n 
A 1 260 GLY 260 262 262 GLY GLY A . n 
A 1 261 TYR 261 263 263 TYR TYR A . n 
A 1 262 GLU 262 264 264 GLU GLU A . n 
A 1 263 SER 263 265 265 SER SER A . n 
A 1 264 ILE 264 266 266 ILE ILE A . n 
A 1 265 VAL 265 267 267 VAL VAL A . n 
A 1 266 PHE 266 268 268 PHE PHE A . n 
A 1 267 ILE 267 269 269 ILE ILE A . n 
A 1 268 GLN 268 270 270 GLN GLN A . n 
A 1 269 ASP 269 271 271 ASP ASP A . n 
A 1 270 THR 270 272 272 THR THR A . n 
A 1 271 ASN 271 273 273 ASN ASN A . n 
A 1 272 ALA 272 274 274 ALA ALA A . n 
A 1 273 GLY 273 275 275 GLY GLY A . n 
A 1 274 ALA 274 276 276 ALA ALA A . n 
A 1 275 THR 275 277 277 THR THR A . n 
A 1 276 ILE 276 278 278 ILE ILE A . n 
A 1 277 THR 277 279 279 THR THR A . n 
A 1 278 ILE 278 280 280 ILE ILE A . n 
A 1 279 PRO 279 281 281 PRO PRO A . n 
A 1 280 ILE 280 282 282 ILE ILE A . n 
A 1 281 SER 281 283 283 SER SER A . n 
A 1 282 LEU 282 284 284 LEU LEU A . n 
A 1 283 ALA 283 285 285 ALA ALA A . n 
A 1 284 LEU 284 286 286 LEU LEU A . n 
A 1 285 SER 285 287 287 SER SER A . n 
A 1 286 ALA 286 288 288 ALA ALA A . n 
A 1 287 GLU 287 289 289 GLU GLU A . n 
A 1 288 HIS 288 290 290 HIS HIS A . n 
A 1 289 SER 289 291 291 SER SER A . n 
A 1 290 LEU 290 292 292 LEU LEU A . n 
A 1 291 ASP 291 293 293 ASP ASP A . n 
A 1 292 MET 292 294 294 MET MET A . n 
A 1 293 ASN 293 295 295 ASN ASN A . n 
A 1 294 PHE 294 296 296 PHE PHE A . n 
A 1 295 THR 295 297 297 THR THR A . n 
A 1 296 CYS 296 298 298 CYS CYS A . n 
A 1 297 ILE 297 299 299 ILE ILE A . n 
A 1 298 PRO 298 300 300 PRO PRO A . n 
A 1 299 ARG 299 301 301 ARG ARG A . n 
A 1 300 VAL 300 302 302 VAL VAL A . n 
A 1 301 PRO 301 303 303 PRO PRO A . n 
A 1 302 LYS 302 304 304 LYS LYS A . n 
A 1 303 GLU 303 305 305 GLU GLU A . n 
A 1 304 PRO 304 306 306 PRO PRO A . n 
A 1 305 ILE 305 307 307 ILE ILE A . n 
A 1 306 GLY 306 308 308 GLY GLY A . n 
A 1 307 LEU 307 309 309 LEU LEU A . n 
A 1 308 LEU 308 310 310 LEU LEU A . n 
A 1 309 CYS 309 311 311 CYS CYS A . n 
A 1 310 ARG 310 312 312 ARG ARG A . n 
A 1 311 THR 311 313 313 THR THR A . n 
A 1 312 LYS 312 314 314 LYS LYS A . n 
A 1 313 LYS 313 315 315 LYS LYS A . n 
A 1 314 ASN 314 316 316 ASN ASN A . n 
A 1 315 SER 315 317 317 SER SER A . n 
A 1 316 GLY 316 318 318 GLY GLY A . n 
A 1 317 ASP 317 319 319 ASP ASP A . n 
A 1 318 PRO 318 320 320 PRO PRO A . n 
A 1 319 TRP 319 321 321 TRP TRP A . n 
A 1 320 LEU 320 322 322 LEU LEU A . n 
A 1 321 VAL 321 323 323 VAL VAL A . n 
A 1 322 ALA 322 324 324 ALA ALA A . n 
A 1 323 ASN 323 325 325 ASN ASN A . n 
A 1 324 VAL 324 326 326 VAL VAL A . n 
A 1 325 GLU 325 327 327 GLU GLU A . n 
A 1 326 TYR 326 328 328 TYR TYR A . n 
A 1 327 ASN 327 329 329 ASN ASN A . n 
A 1 328 VAL 328 330 330 VAL VAL A . n 
A 1 329 PHE 329 331 331 PHE PHE A . n 
A 1 330 ALA 330 332 332 ALA ALA A . n 
A 1 331 GLU 331 333 333 GLU GLU A . n 
A 1 332 VAL 332 334 334 VAL VAL A . n 
A 1 333 SER 333 335 335 SER SER A . n 
A 1 334 ARG 334 336 336 ARG ARG A . n 
A 1 335 ALA 335 337 337 ALA ALA A . n 
A 1 336 LEU 336 338 338 LEU LEU A . n 
A 1 337 ASN 337 339 339 ASN ASN A . n 
A 1 338 LYS 338 340 340 LYS LYS A . n 
A 1 339 ASP 339 341 341 ASP ASP A . n 
A 1 340 GLY 340 342 342 GLY GLY A . n 
A 1 341 GLY 341 343 343 GLY GLY A . n 
A 1 342 ASP 342 344 344 ASP ASP A . n 
A 1 343 GLU 343 345 345 GLU GLU A . n 
A 1 344 VAL 344 346 346 VAL VAL A . n 
A 1 345 SER 345 347 347 SER SER A . n 
A 1 346 ASP 346 348 348 ASP ASP A . n 
A 1 347 PRO 347 349 349 PRO PRO A . n 
A 1 348 THR 348 350 350 THR THR A . n 
A 1 349 GLY 349 351 351 GLY GLY A . n 
A 1 350 PHE 350 352 352 PHE PHE A . n 
A 1 351 SER 351 353 353 SER SER A . n 
A 1 352 PRO 352 354 354 PRO PRO A . n 
A 1 353 PHE 353 355 355 PHE PHE A . n 
A 1 354 PRO 354 356 356 PRO PRO A . n 
A 1 355 GLY 355 357 357 GLY GLY A . n 
A 1 356 SER 356 358 358 SER SER A . n 
A 1 357 VAL 357 359 359 VAL VAL A . n 
A 1 358 ASN 358 360 360 ASN ASN A . n 
A 1 359 THR 359 361 361 THR THR A . n 
A 1 360 LEU 360 362 362 LEU LEU A . n 
A 1 361 VAL 361 363 363 VAL VAL A . n 
A 1 362 PHE 362 364 364 PHE PHE A . n 
A 1 363 LYS 363 365 365 LYS LYS A . n 
A 1 364 LEU 364 366 366 LEU LEU A . n 
A 1 365 SER 365 367 367 SER SER A . n 
A 1 366 SER 366 368 368 SER SER A . n 
A 1 367 TYR 367 369 369 TYR TYR A . n 
A 1 368 VAL 368 370 370 VAL VAL A . n 
A 1 369 ASP 369 371 371 ASP ASP A . n 
A 1 370 ARG 370 372 372 ARG ARG A . n 
A 1 371 LEU 371 373 373 LEU LEU A . n 
A 1 372 ARG 372 374 374 ARG ARG A . n 
A 1 373 GLU 373 375 375 GLU GLU A . n 
A 1 374 SER 374 376 376 SER SER A . n 
A 1 375 HIS 375 377 377 HIS HIS A . n 
A 1 376 GLY 376 378 378 GLY GLY A . n 
A 1 377 ILE 377 379 379 ILE ILE A . n 
A 1 378 VAL 378 380 380 VAL VAL A . n 
A 1 379 PRO 379 381 381 PRO PRO A . n 
A 1 380 GLU 380 382 382 GLU GLU A . n 
A 1 381 PHE 381 383 383 PHE PHE A . n 
A 1 382 ILE 382 384 384 ILE ILE A . n 
A 1 383 ASN 383 385 385 ASN ASN A . n 
A 1 384 PRO 384 386 386 PRO PRO A . n 
A 1 385 LYS 385 387 387 LYS LYS A . n 
A 1 386 TYR 386 388 388 TYR TYR A . n 
A 1 387 SER 387 389 389 SER SER A . n 
A 1 388 ASP 388 390 390 ASP ASP A . n 
A 1 389 GLU 389 391 391 GLU GLU A . n 
A 1 390 THR 390 392 392 THR THR A . n 
A 1 391 ARG 391 393 393 ARG ARG A . n 
A 1 392 ARG 392 394 394 ARG ARG A . n 
A 1 393 SER 393 395 395 SER SER A . n 
A 1 394 PHE 394 396 396 PHE PHE A . n 
A 1 395 LYS 395 397 397 LYS LYS A . n 
A 1 396 LYS 396 398 398 LYS LYS A . n 
A 1 397 PRO 397 399 399 PRO PRO A . n 
A 1 398 ALA 398 400 400 ALA ALA A . n 
A 1 399 ARG 399 401 401 ARG ARG A . n 
A 1 400 ILE 400 402 402 ILE ILE A . n 
A 1 401 GLU 401 403 403 GLU GLU A . n 
A 1 402 SER 402 404 404 SER SER A . n 
A 1 403 LEU 403 405 405 LEU LEU A . n 
A 1 404 MET 404 406 406 MET MET A . n 
A 1 405 GLN 405 407 407 GLN GLN A . n 
A 1 406 ASP 406 408 408 ASP ASP A . n 
A 1 407 ILE 407 409 409 ILE ILE A . n 
A 1 408 ALA 408 410 410 ALA ALA A . n 
A 1 409 LEU 409 411 411 LEU LEU A . n 
A 1 410 LEU 410 412 412 LEU LEU A . n 
A 1 411 PHE 411 413 413 PHE PHE A . n 
A 1 412 SER 412 414 414 SER SER A . n 
A 1 413 GLU 413 415 415 GLU GLU A . n 
A 1 414 ASP 414 416 416 ASP ASP A . n 
A 1 415 ASP 415 417 417 ASP ASP A . n 
A 1 416 TYR 416 418 418 TYR TYR A . n 
A 1 417 ARG 417 419 419 ARG ARG A . n 
A 1 418 VAL 418 420 420 VAL VAL A . n 
A 1 419 GLY 419 421 421 GLY GLY A . n 
A 1 420 GLY 420 422 422 GLY GLY A . n 
A 1 421 THR 421 423 423 THR THR A . n 
A 1 422 VAL 422 424 424 VAL VAL A . n 
A 1 423 PHE 423 425 425 PHE PHE A . n 
A 1 424 GLU 424 426 426 GLU GLU A . n 
A 1 425 ARG 425 427 427 ARG ARG A . n 
A 1 426 PHE 426 428 428 PHE PHE A . n 
A 1 427 SER 427 429 429 SER SER A . n 
A 1 428 TYR 428 430 430 TYR TYR A . n 
A 1 429 GLN 429 431 431 GLN GLN A . n 
A 1 430 PRO 430 432 432 PRO PRO A . n 
A 1 431 VAL 431 433 433 VAL VAL A . n 
A 1 432 LYS 432 434 434 LYS LYS A . n 
A 1 433 ASN 433 435 435 ASN ASN A . n 
A 1 434 SER 434 436 436 SER SER A . n 
A 1 435 LEU 435 437 437 LEU LEU A . n 
A 1 436 GLU 436 438 438 GLU GLU A . n 
A 1 437 GLU 437 439 439 GLU GLU A . n 
A 1 438 ALA 438 440 440 ALA ALA A . n 
A 1 439 ALA 439 441 441 ALA ALA A . n 
A 1 440 GLY 440 442 442 GLY GLY A . n 
A 1 441 LEU 441 443 443 LEU LEU A . n 
A 1 442 VAL 442 444 444 VAL VAL A . n 
A 1 443 ALA 443 445 445 ALA ALA A . n 
A 1 444 GLN 444 446 446 GLN GLN A . n 
A 1 445 GLY 445 447 447 GLY GLY A . n 
A 1 446 ASN 446 448 448 ASN ASN A . n 
A 1 447 GLY 447 449 449 GLY GLY A . n 
A 1 448 ALA 448 450 450 ALA ALA A . n 
A 1 449 TYR 449 451 451 TYR TYR A . n 
A 1 450 CYS 450 452 452 CYS CYS A . n 
A 1 451 ALA 451 453 453 ALA ALA A . n 
A 1 452 ALA 452 454 454 ALA ALA A . n 
A 1 453 THR 453 455 455 THR THR A . n 
A 1 454 GLY 454 456 456 GLY GLY A . n 
A 1 455 GLU 455 457 457 GLU GLU A . n 
A 1 456 ALA 456 458 458 ALA ALA A . n 
A 1 457 ALA 457 459 459 ALA ALA A . n 
A 1 458 PHE 458 460 460 PHE PHE A . n 
A 1 459 TYR 459 461 461 TYR TYR A . n 
A 1 460 GLU 460 462 462 GLU GLU A . n 
A 1 461 LEU 461 463 463 LEU LEU A . n 
A 1 462 GLN 462 464 464 GLN GLN A . n 
A 1 463 ARG 463 465 465 ARG ARG A . n 
A 1 464 ARG 464 466 466 ARG ARG A . n 
A 1 465 ARG 465 467 467 ARG ARG A . n 
A 1 466 LEU 466 468 468 LEU LEU A . n 
A 1 467 LYS 467 469 469 LYS LYS A . n 
A 1 468 ALA 468 470 470 ALA ALA A . n 
A 1 469 ILE 469 471 471 ILE ILE A . n 
A 1 470 GLY 470 472 472 GLY GLY A . n 
A 1 471 LEU 471 473 473 LEU LEU A . n 
A 1 472 PRO 472 474 474 PRO PRO A . n 
A 1 473 LEU 473 475 475 LEU LEU A . n 
A 1 474 PHE 474 476 476 PHE PHE A . n 
A 1 475 TYR 475 477 477 TYR TYR A . n 
A 1 476 SER 476 478 478 SER SER A . n 
A 1 477 SER 477 479 479 SER SER A . n 
A 1 478 GLN 478 480 480 GLN GLN A . n 
A 1 479 PRO 479 481 481 PRO PRO A . n 
A 1 480 GLU 480 482 482 GLU GLU A . n 
A 1 481 VAL 481 483 483 VAL VAL A . n 
A 1 482 THR 482 484 484 THR THR A . n 
A 1 483 VAL 483 485 485 VAL VAL A . n 
A 1 484 ALA 484 486 486 ALA ALA A . n 
A 1 485 LYS 485 487 487 LYS LYS A . n 
A 1 486 ASP 486 488 488 ASP ASP A . n 
A 1 487 ALA 487 489 489 ALA ALA A . n 
A 1 488 PHE 488 490 490 PHE PHE A . n 
A 1 489 GLY 489 491 491 GLY GLY A . n 
A 1 490 VAL 490 492 492 VAL VAL A . n 
A 1 491 ARG 491 493 493 ARG ARG A . n 
A 1 492 LEU 492 494 494 LEU LEU A . n 
A 1 493 PHE 493 495 495 PHE PHE A . n 
A 1 494 PRO 494 496 496 PRO PRO A . n 
A 1 495 ILE 495 497 497 ILE ILE A . n 
A 1 496 ILE 496 498 498 ILE ILE A . n 
A 1 497 VAL 497 499 499 VAL VAL A . n 
A 1 498 LEU 498 500 500 LEU LEU A . n 
A 1 499 ASP 499 501 501 ASP ASP A . n 
A 1 500 THR 500 502 502 THR THR A . n 
A 1 501 VAL 501 503 503 VAL VAL A . n 
A 1 502 CYS 502 504 504 CYS CYS A . n 
A 1 503 ALA 503 505 505 ALA ALA A . n 
A 1 504 SER 504 506 506 SER SER A . n 
A 1 505 SER 505 507 507 SER SER A . n 
A 1 506 GLY 506 508 508 GLY GLY A . n 
A 1 507 SER 507 509 509 SER SER A . n 
A 1 508 LEU 508 510 510 LEU LEU A . n 
A 1 509 ASP 509 511 511 ASP ASP A . n 
A 1 510 ASP 510 512 512 ASP ASP A . n 
A 1 511 LEU 511 513 513 LEU LEU A . n 
A 1 512 ALA 512 514 514 ALA ALA A . n 
A 1 513 ARG 513 515 515 ARG ARG A . n 
A 1 514 VAL 514 516 516 VAL VAL A . n 
A 1 515 PHE 515 517 517 PHE PHE A . n 
A 1 516 PRO 516 518 518 PRO PRO A . n 
A 1 517 THR 517 519 519 THR THR A . n 
A 1 518 PRO 518 520 520 PRO PRO A . n 
A 1 519 GLU 519 521 521 GLU GLU A . n 
A 1 520 LYS 520 522 522 LYS LYS A . n 
A 1 521 VAL 521 523 523 VAL VAL A . n 
A 1 522 HIS 522 524 524 HIS HIS A . n 
A 1 523 ILE 523 525 525 ILE ILE A . n 
A 1 524 ASP 524 526 526 ASP ASP A . n 
A 1 525 GLN 525 527 527 GLN GLN A . n 
A 1 526 HIS 526 528 528 HIS HIS A . n 
A 1 527 SER 527 529 529 SER SER A . n 
A 1 528 THR 528 530 530 THR THR A . n 
A 1 529 LEU 529 531 531 LEU LEU A . n 
A 1 530 ILE 530 532 532 ILE ILE A . n 
A 1 531 VAL 531 533 533 VAL VAL A . n 
A 1 532 GLU 532 534 534 GLU GLU A . n 
A 1 533 GLY 533 535 535 GLY GLY A . n 
A 1 534 ARG 534 536 536 ARG ARG A . n 
A 1 535 VAL 535 537 537 VAL VAL A . n 
A 1 536 ILE 536 538 538 ILE ILE A . n 
A 1 537 ILE 537 539 539 ILE ILE A . n 
A 1 538 GLU 538 540 540 GLU GLU A . n 
A 1 539 SER 539 541 541 SER SER A . n 
A 1 540 LEU 540 542 542 LEU LEU A . n 
A 1 541 GLU 541 543 543 GLU GLU A . n 
A 1 542 LEU 542 544 544 LEU LEU A . n 
A 1 543 TYR 543 545 545 TYR TYR A . n 
A 1 544 GLY 544 546 546 GLY GLY A . n 
A 1 545 ALA 545 547 547 ALA ALA A . n 
A 1 546 LEU 546 548 548 LEU LEU A . n 
A 1 547 THR 547 549 549 THR THR A . n 
A 1 548 ILE 548 550 550 ILE ILE A . n 
A 1 549 ARG 549 551 551 ARG ARG A . n 
A 1 550 GLY 550 552 552 GLY GLY A . n 
A 1 551 PRO 551 553 553 PRO PRO A . n 
A 1 552 THR 552 554 554 THR THR A . n 
A 1 553 ASP 553 555 555 ASP ASP A . n 
A 1 554 SER 554 556 556 SER SER A . n 
A 1 555 MET 555 557 557 MET MET A . n 
A 1 556 ALA 556 558 558 ALA ALA A . n 
A 1 557 LEU 557 559 559 LEU LEU A . n 
A 1 558 PRO 558 560 560 PRO PRO A . n 
A 1 559 HIS 559 561 561 HIS HIS A . n 
A 1 560 VAL 560 562 562 VAL VAL A . n 
A 1 561 VAL 561 563 563 VAL VAL A . n 
A 1 562 ARG 562 564 564 ARG ARG A . n 
A 1 563 ASN 563 565 565 ASN ASN A . n 
A 1 564 ALA 564 566 566 ALA ALA A . n 
A 1 565 VAL 565 567 567 VAL VAL A . n 
A 1 566 VAL 566 568 568 VAL VAL A . n 
A 1 567 ARG 567 569 569 ARG ARG A . n 
A 1 568 ASN 568 570 570 ASN ASN A . n 
A 1 569 ALA 569 571 571 ALA ALA A . n 
A 1 570 GLY 570 572 572 GLY GLY A . n 
A 1 571 TRP 571 573 573 TRP TRP A . n 
A 1 572 SER 572 574 574 SER SER A . n 
A 1 573 VAL 573 575 575 VAL VAL A . n 
A 1 574 HIS 574 576 576 HIS HIS A . n 
A 1 575 ALA 575 577 577 ALA ALA A . n 
A 1 576 ILE 576 578 578 ILE ILE A . n 
A 1 577 LEU 577 579 579 LEU LEU A . n 
A 1 578 SER 578 580 580 SER SER A . n 
A 1 579 LEU 579 581 581 LEU LEU A . n 
A 1 580 CYS 580 582 582 CYS CYS A . n 
A 1 581 ALA 581 583 583 ALA ALA A . n 
A 1 582 GLY 582 584 584 GLY GLY A . n 
A 1 583 ARG 583 585 585 ARG ARG A . n 
A 1 584 ASP 584 586 586 ASP ASP A . n 
A 1 585 SER 585 587 587 SER SER A . n 
A 1 586 ARG 586 588 588 ARG ARG A . n 
A 1 587 LEU 587 589 589 LEU LEU A . n 
A 1 588 SER 588 590 590 SER SER A . n 
A 1 589 GLU 589 591 591 GLU GLU A . n 
A 1 590 VAL 590 592 592 VAL VAL A . n 
A 1 591 ASP 591 593 593 ASP ASP A . n 
A 1 592 ARG 592 594 594 ARG ARG A . n 
A 1 593 ILE 593 595 595 ILE ILE A . n 
A 1 594 ARG 594 596 596 ARG ARG A . n 
A 1 595 GLY 595 597 597 GLY GLY A . n 
A 1 596 PHE 596 598 598 PHE PHE A . n 
A 1 597 VAL 597 599 599 VAL VAL A . n 
A 1 598 LEU 598 600 600 LEU LEU A . n 
A 1 599 LYS 599 601 601 LYS LYS A . n 
A 1 600 LYS 600 602 602 LYS LYS A . n 
A 1 601 THR 601 603 603 THR THR A . n 
A 1 602 ALA 602 604 604 ALA ALA A . n 
A 1 603 MET 603 605 605 MET MET A . n 
A 1 604 ALA 604 606 606 ALA ALA A . n 
A 1 605 VAL 605 607 607 VAL VAL A . n 
A 1 606 MET 606 608 608 MET MET A . n 
A 1 607 ASP 607 609 609 ASP ASP A . n 
A 1 608 CYS 608 610 610 CYS CYS A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 UPG ? ? UPG ? ? 'SUBJECT OF INVESTIGATION' ? 
2 POP ? ? POP ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UPG 1   700  700 UPG UPG A . 
C 3 POP 1   701  701 POP POP A . 
D 3 POP 1   702  702 POP POP A . 
E 4 HOH 1   801  142 HOH HOH A . 
E 4 HOH 2   802  302 HOH HOH A . 
E 4 HOH 3   803  162 HOH HOH A . 
E 4 HOH 4   804  340 HOH HOH A . 
E 4 HOH 5   805  85  HOH HOH A . 
E 4 HOH 6   806  476 HOH HOH A . 
E 4 HOH 7   807  608 HOH HOH A . 
E 4 HOH 8   808  532 HOH HOH A . 
E 4 HOH 9   809  491 HOH HOH A . 
E 4 HOH 10  810  582 HOH HOH A . 
E 4 HOH 11  811  525 HOH HOH A . 
E 4 HOH 12  812  13  HOH HOH A . 
E 4 HOH 13  813  437 HOH HOH A . 
E 4 HOH 14  814  487 HOH HOH A . 
E 4 HOH 15  815  623 HOH HOH A . 
E 4 HOH 16  816  561 HOH HOH A . 
E 4 HOH 17  817  526 HOH HOH A . 
E 4 HOH 18  818  499 HOH HOH A . 
E 4 HOH 19  819  559 HOH HOH A . 
E 4 HOH 20  820  477 HOH HOH A . 
E 4 HOH 21  821  436 HOH HOH A . 
E 4 HOH 22  822  290 HOH HOH A . 
E 4 HOH 23  823  535 HOH HOH A . 
E 4 HOH 24  824  611 HOH HOH A . 
E 4 HOH 25  825  216 HOH HOH A . 
E 4 HOH 26  826  598 HOH HOH A . 
E 4 HOH 27  827  564 HOH HOH A . 
E 4 HOH 28  828  581 HOH HOH A . 
E 4 HOH 29  829  541 HOH HOH A . 
E 4 HOH 30  830  130 HOH HOH A . 
E 4 HOH 31  831  578 HOH HOH A . 
E 4 HOH 32  832  281 HOH HOH A . 
E 4 HOH 33  833  441 HOH HOH A . 
E 4 HOH 34  834  620 HOH HOH A . 
E 4 HOH 35  835  482 HOH HOH A . 
E 4 HOH 36  836  502 HOH HOH A . 
E 4 HOH 37  837  519 HOH HOH A . 
E 4 HOH 38  838  596 HOH HOH A . 
E 4 HOH 39  839  483 HOH HOH A . 
E 4 HOH 40  840  227 HOH HOH A . 
E 4 HOH 41  841  626 HOH HOH A . 
E 4 HOH 42  842  36  HOH HOH A . 
E 4 HOH 43  843  172 HOH HOH A . 
E 4 HOH 44  844  171 HOH HOH A . 
E 4 HOH 45  845  299 HOH HOH A . 
E 4 HOH 46  846  523 HOH HOH A . 
E 4 HOH 47  847  393 HOH HOH A . 
E 4 HOH 48  848  475 HOH HOH A . 
E 4 HOH 49  849  406 HOH HOH A . 
E 4 HOH 50  850  637 HOH HOH A . 
E 4 HOH 51  851  108 HOH HOH A . 
E 4 HOH 52  852  146 HOH HOH A . 
E 4 HOH 53  853  508 HOH HOH A . 
E 4 HOH 54  854  111 HOH HOH A . 
E 4 HOH 55  855  116 HOH HOH A . 
E 4 HOH 56  856  105 HOH HOH A . 
E 4 HOH 57  857  128 HOH HOH A . 
E 4 HOH 58  859  570 HOH HOH A . 
E 4 HOH 59  860  633 HOH HOH A . 
E 4 HOH 60  861  1   HOH HOH A . 
E 4 HOH 61  862  468 HOH HOH A . 
E 4 HOH 62  863  610 HOH HOH A . 
E 4 HOH 63  864  627 HOH HOH A . 
E 4 HOH 64  865  513 HOH HOH A . 
E 4 HOH 65  866  490 HOH HOH A . 
E 4 HOH 66  867  545 HOH HOH A . 
E 4 HOH 67  868  8   HOH HOH A . 
E 4 HOH 68  869  603 HOH HOH A . 
E 4 HOH 69  870  357 HOH HOH A . 
E 4 HOH 70  871  616 HOH HOH A . 
E 4 HOH 71  872  301 HOH HOH A . 
E 4 HOH 72  873  57  HOH HOH A . 
E 4 HOH 73  874  294 HOH HOH A . 
E 4 HOH 74  875  397 HOH HOH A . 
E 4 HOH 75  876  566 HOH HOH A . 
E 4 HOH 76  877  404 HOH HOH A . 
E 4 HOH 77  878  243 HOH HOH A . 
E 4 HOH 78  879  14  HOH HOH A . 
E 4 HOH 79  880  594 HOH HOH A . 
E 4 HOH 80  881  412 HOH HOH A . 
E 4 HOH 81  882  286 HOH HOH A . 
E 4 HOH 82  883  341 HOH HOH A . 
E 4 HOH 83  884  572 HOH HOH A . 
E 4 HOH 84  885  175 HOH HOH A . 
E 4 HOH 85  886  313 HOH HOH A . 
E 4 HOH 86  887  494 HOH HOH A . 
E 4 HOH 87  888  120 HOH HOH A . 
E 4 HOH 88  889  316 HOH HOH A . 
E 4 HOH 89  890  609 HOH HOH A . 
E 4 HOH 90  891  600 HOH HOH A . 
E 4 HOH 91  892  19  HOH HOH A . 
E 4 HOH 92  893  331 HOH HOH A . 
E 4 HOH 93  894  567 HOH HOH A . 
E 4 HOH 94  895  592 HOH HOH A . 
E 4 HOH 95  896  558 HOH HOH A . 
E 4 HOH 96  897  248 HOH HOH A . 
E 4 HOH 97  898  11  HOH HOH A . 
E 4 HOH 98  899  31  HOH HOH A . 
E 4 HOH 99  900  470 HOH HOH A . 
E 4 HOH 100 901  23  HOH HOH A . 
E 4 HOH 101 902  91  HOH HOH A . 
E 4 HOH 102 903  300 HOH HOH A . 
E 4 HOH 103 904  207 HOH HOH A . 
E 4 HOH 104 905  584 HOH HOH A . 
E 4 HOH 105 906  562 HOH HOH A . 
E 4 HOH 106 907  580 HOH HOH A . 
E 4 HOH 107 908  27  HOH HOH A . 
E 4 HOH 108 909  410 HOH HOH A . 
E 4 HOH 109 910  347 HOH HOH A . 
E 4 HOH 110 911  575 HOH HOH A . 
E 4 HOH 111 912  551 HOH HOH A . 
E 4 HOH 112 913  375 HOH HOH A . 
E 4 HOH 113 914  144 HOH HOH A . 
E 4 HOH 114 915  303 HOH HOH A . 
E 4 HOH 115 916  364 HOH HOH A . 
E 4 HOH 116 917  323 HOH HOH A . 
E 4 HOH 117 918  12  HOH HOH A . 
E 4 HOH 118 919  606 HOH HOH A . 
E 4 HOH 119 920  360 HOH HOH A . 
E 4 HOH 120 921  474 HOH HOH A . 
E 4 HOH 121 922  426 HOH HOH A . 
E 4 HOH 122 923  29  HOH HOH A . 
E 4 HOH 123 924  601 HOH HOH A . 
E 4 HOH 124 925  274 HOH HOH A . 
E 4 HOH 125 926  405 HOH HOH A . 
E 4 HOH 126 927  635 HOH HOH A . 
E 4 HOH 127 928  634 HOH HOH A . 
E 4 HOH 128 929  503 HOH HOH A . 
E 4 HOH 129 930  488 HOH HOH A . 
E 4 HOH 130 931  573 HOH HOH A . 
E 4 HOH 131 932  489 HOH HOH A . 
E 4 HOH 132 933  498 HOH HOH A . 
E 4 HOH 133 934  590 HOH HOH A . 
E 4 HOH 134 935  421 HOH HOH A . 
E 4 HOH 135 936  292 HOH HOH A . 
E 4 HOH 136 937  589 HOH HOH A . 
E 4 HOH 137 938  399 HOH HOH A . 
E 4 HOH 138 939  59  HOH HOH A . 
E 4 HOH 139 940  588 HOH HOH A . 
E 4 HOH 140 941  497 HOH HOH A . 
E 4 HOH 141 942  400 HOH HOH A . 
E 4 HOH 142 943  356 HOH HOH A . 
E 4 HOH 143 944  439 HOH HOH A . 
E 4 HOH 144 945  186 HOH HOH A . 
E 4 HOH 145 946  615 HOH HOH A . 
E 4 HOH 146 947  512 HOH HOH A . 
E 4 HOH 147 948  117 HOH HOH A . 
E 4 HOH 148 949  624 HOH HOH A . 
E 4 HOH 149 950  614 HOH HOH A . 
E 4 HOH 150 951  4   HOH HOH A . 
E 4 HOH 151 952  266 HOH HOH A . 
E 4 HOH 152 953  2   HOH HOH A . 
E 4 HOH 153 954  613 HOH HOH A . 
E 4 HOH 154 955  593 HOH HOH A . 
E 4 HOH 155 956  617 HOH HOH A . 
E 4 HOH 156 957  445 HOH HOH A . 
E 4 HOH 157 958  456 HOH HOH A . 
E 4 HOH 158 959  585 HOH HOH A . 
E 4 HOH 159 960  612 HOH HOH A . 
E 4 HOH 160 961  586 HOH HOH A . 
E 4 HOH 161 962  563 HOH HOH A . 
E 4 HOH 162 963  21  HOH HOH A . 
E 4 HOH 163 964  516 HOH HOH A . 
E 4 HOH 164 965  632 HOH HOH A . 
E 4 HOH 165 966  349 HOH HOH A . 
E 4 HOH 166 967  543 HOH HOH A . 
E 4 HOH 167 968  595 HOH HOH A . 
E 4 HOH 168 969  629 HOH HOH A . 
E 4 HOH 169 970  577 HOH HOH A . 
E 4 HOH 170 971  151 HOH HOH A . 
E 4 HOH 171 972  258 HOH HOH A . 
E 4 HOH 172 973  597 HOH HOH A . 
E 4 HOH 173 974  450 HOH HOH A . 
E 4 HOH 174 975  270 HOH HOH A . 
E 4 HOH 175 976  552 HOH HOH A . 
E 4 HOH 176 977  479 HOH HOH A . 
E 4 HOH 177 978  560 HOH HOH A . 
E 4 HOH 178 979  587 HOH HOH A . 
E 4 HOH 179 980  527 HOH HOH A . 
E 4 HOH 180 981  549 HOH HOH A . 
E 4 HOH 181 982  622 HOH HOH A . 
E 4 HOH 182 983  576 HOH HOH A . 
E 4 HOH 183 984  625 HOH HOH A . 
E 4 HOH 184 985  565 HOH HOH A . 
E 4 HOH 185 986  518 HOH HOH A . 
E 4 HOH 186 987  636 HOH HOH A . 
E 4 HOH 187 988  272 HOH HOH A . 
E 4 HOH 188 989  500 HOH HOH A . 
E 4 HOH 189 990  416 HOH HOH A . 
E 4 HOH 190 991  505 HOH HOH A . 
E 4 HOH 191 992  332 HOH HOH A . 
E 4 HOH 192 993  170 HOH HOH A . 
E 4 HOH 193 994  639 HOH HOH A . 
E 4 HOH 194 995  521 HOH HOH A . 
E 4 HOH 195 996  544 HOH HOH A . 
E 4 HOH 196 997  605 HOH HOH A . 
E 4 HOH 197 998  293 HOH HOH A . 
E 4 HOH 198 999  630 HOH HOH A . 
E 4 HOH 199 1000 484 HOH HOH A . 
E 4 HOH 200 1001 507 HOH HOH A . 
E 4 HOH 201 1002 569 HOH HOH A . 
E 4 HOH 202 1003 571 HOH HOH A . 
E 4 HOH 203 1004 352 HOH HOH A . 
E 4 HOH 204 1005 618 HOH HOH A . 
E 4 HOH 205 1006 574 HOH HOH A . 
E 4 HOH 206 1007 345 HOH HOH A . 
E 4 HOH 207 1008 631 HOH HOH A . 
E 4 HOH 208 1009 509 HOH HOH A . 
E 4 HOH 209 1010 599 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0267 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SADABS ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.69 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8TG2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     107.090 
_cell.length_a_esd                 ? 
_cell.length_b                     121.900 
_cell.length_b_esd                 ? 
_cell.length_c                     60.960 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8TG2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8TG2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.77 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.67 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'200 mM ammonium acetate, 100 mM tri-sodium citrate, pH 5.4 - 5.6, and 15% - 17% polyethylene glycol-4000 (PEG-4000)' 
_exptl_crystal_grow.pdbx_pH_range   '5.4 - 5.6' 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2018-10-19 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9763 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9763 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'P13 (MX1)' 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, EMBL c/o DESY' 
# 
_reflns.B_iso_Wilson_estimate                          76.042 
_reflns.entry_id                                       8TG2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.40 
_reflns.d_resolution_low                               52.6 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29455 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.92 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          19.00 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.0451 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.0270 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.40 
_reflns_shell.d_res_low                                     2.5 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3375 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.67 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.901 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.5176 
_reflns_shell.pdbx_Rsym_value                               0.4020 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.58 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            -1.68 
_refine.aniso_B[2][2]                            -1.02 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            2.20 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               71.313 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.960 
_refine.correlation_coeff_Fo_to_Fc_free          0.950 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8TG2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.40 
_refine.ls_d_res_low                             52.59 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27910 
_refine.ls_number_reflns_R_free                  1544 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.97 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20784 
_refine.ls_R_factor_R_free                       0.23626 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20630 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD WITH PHASES' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.397 
_refine.pdbx_overall_ESU_R_Free                  0.244 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.40 
_refine_hist.d_res_low                        52.59 
_refine_hist.number_atoms_solvent             210 
_refine_hist.number_atoms_total               4970 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4706 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         54 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  0.013  4859  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.035  0.015  4567  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.238  1.644  6616  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 2.225  1.573  10514 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 5.386  5.000  607   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 31.587 21.660 253   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.916 15.000 789   ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 16.829 15.000 37    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.059  0.200  638   ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.011  0.020  5478  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.024  0.020  1100  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 5.095  7.601  2431  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.096  7.599  2430  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 7.090  11.418 3037  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 7.089  11.420 3038  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.166  7.782  2428  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.112  7.770  2413  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 7.006  11.526 3554  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 9.368  88.911 5180  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 9.363  88.867 5168  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.400 
_refine_ls_shell.d_res_low                        2.462 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             113 
_refine_ls_shell.number_reflns_R_work             2047 
_refine_ls_shell.percent_reflns_obs               99.68 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.328 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.382 
# 
_struct.entry_id                     8TG2 
_struct.title                        
;The crystal structure of the post-reactive state of UDP-sugar pyrophosphorylase from Leishmania major in complex with products UDP-Glucose and PPi
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8TG2 
_struct_keywords.text            
'carbohydrate biosynthesis, nucleotidyltransferase, catalysis, molecular mechanism, SUGAR BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'SUGAR BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    D3G6S4_LEIMA 
_struct_ref.pdbx_db_accession          D3G6S4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;NPSNSNLQALREELCTPGLDQGHLFEGWPETVDECNERQIALLTDLYMFSNMYPGGVAQYIRNGHELLARESEEVDFAAL
EMPPLIFEAPSLHRRTAERTALENAGTAMLCKTVFVLVAGGLGERLGYSSIKVSLPVETATNTTYLAYYLRWAQRVGGKE
VPFVIMTSDDTHDRTLQLLRELQLEVPNLHVLKQGQVFCFADSAAHLALDETGKLLRKPHGHGDVHSLIYNATVKRDVVP
DSGDGTATAQPLVNDWLAAGYESIVFIQDTNAGATITIPISLALSAEHSLDMNFTCIPRVPKEPIGLLCRTKKNSGDPWL
VANVEYNVFAEVSRALNKDGGDEVSDPTGFSPFPGSVNTLVFKLSSYVDRLRESHGIVPEFINPKYSDETRRSFKKPARI
ESLMQDIALLFSEDDYRVGGTVFERFSYQPVKNSLEEAAGLVAQGNGAYCAATGEAAFYELQRRRLKAIGLPLFYSSQPE
VTVAKDAFGVRLFPIIVLDTVCASSGSLDDLARVFPTPEKVHIDQHSTLIVEGRVIIESLELYGALTIRGPTDSMALPHV
VRNAVVRNAGWSVHAILSLCAGRDSRLSEVDRIRGFVLKKTAMAVMDC
;
_struct_ref.pdbx_align_begin           3 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8TG2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 608 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             D3G6S4 
_struct_ref_seq.db_align_beg                  3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  610 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       3 
_struct_ref_seq.pdbx_auth_seq_align_end       610 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 3   ? CYS A 15  ? SER A 5   CYS A 17  1 ? 13 
HELX_P HELX_P2  AA2 GLN A 21  ? GLU A 26  ? GLN A 23  GLU A 28  5 ? 6  
HELX_P HELX_P3  AA3 ASN A 36  ? PHE A 49  ? ASN A 38  PHE A 51  1 ? 14 
HELX_P HELX_P4  AA4 SER A 50  ? MET A 52  ? SER A 52  MET A 54  5 ? 3  
HELX_P HELX_P5  AA5 GLY A 55  ? GLU A 73  ? GLY A 57  GLU A 75  1 ? 19 
HELX_P HELX_P6  AA6 THR A 96  ? CYS A 111 ? THR A 98  CYS A 113 1 ? 16 
HELX_P HELX_P7  AA7 GLY A 123 ? GLY A 127 ? GLY A 125 GLY A 129 5 ? 5  
HELX_P HELX_P8  AA8 ILE A 131 ? LEU A 135 ? ILE A 133 LEU A 137 5 ? 5  
HELX_P HELX_P9  AA9 THR A 144 ? GLY A 158 ? THR A 146 GLY A 160 1 ? 15 
HELX_P HELX_P10 AB1 THR A 171 ? GLN A 183 ? THR A 173 GLN A 185 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 221 ? GLY A 223 ? GLY A 223 GLY A 225 5 ? 3  
HELX_P HELX_P12 AB3 ASP A 224 ? ASN A 231 ? ASP A 226 ASN A 233 1 ? 8  
HELX_P HELX_P13 AB4 LEU A 252 ? GLY A 260 ? LEU A 254 GLY A 262 1 ? 9  
HELX_P HELX_P14 AB5 GLY A 273 ? HIS A 288 ? GLY A 275 HIS A 290 1 ? 16 
HELX_P HELX_P15 AB6 GLU A 325 ? ALA A 335 ? GLU A 327 ALA A 337 1 ? 11 
HELX_P HELX_P16 AB7 LEU A 364 ? HIS A 375 ? LEU A 366 HIS A 377 1 ? 12 
HELX_P HELX_P17 AB8 LEU A 403 ? PHE A 411 ? LEU A 405 PHE A 413 5 ? 9  
HELX_P HELX_P18 AB9 GLU A 424 ? TYR A 428 ? GLU A 426 TYR A 430 5 ? 5  
HELX_P HELX_P19 AC1 SER A 434 ? GLN A 444 ? SER A 436 GLN A 446 1 ? 11 
HELX_P HELX_P20 AC2 CYS A 450 ? ILE A 469 ? CYS A 452 ILE A 471 1 ? 20 
HELX_P HELX_P21 AC3 ASP A 499 ? SER A 504 ? ASP A 501 SER A 506 1 ? 6  
HELX_P HELX_P22 AC4 SER A 507 ? PHE A 515 ? SER A 509 PHE A 517 1 ? 9  
HELX_P HELX_P23 AC5 THR A 517 ? GLU A 519 ? THR A 519 GLU A 521 5 ? 3  
HELX_P HELX_P24 AC6 SER A 588 ? ILE A 593 ? SER A 590 ILE A 595 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 THR 248 A . ? THR 250 A ALA 249 A ? ALA 251 A 1 10.24 
2 PHE 493 A . ? PHE 495 A PRO 494 A ? PRO 496 A 1 -3.85 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 8 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
AA7 ? 4 ? 
AA8 ? 3 ? 
AA9 ? 2 ? 
AB1 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? parallel      
AA2 6 7 ? parallel      
AA2 7 8 ? parallel      
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? parallel      
AA7 3 4 ? parallel      
AA8 1 2 ? parallel      
AA8 2 3 ? parallel      
AA9 1 2 ? parallel      
AB1 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 79  ? GLU A 81  ? ALA A 81  GLU A 83  
AA1 2 LEU A 307 ? LYS A 312 ? LEU A 309 LYS A 314 
AA1 3 LEU A 320 ? VAL A 324 ? LEU A 322 VAL A 326 
AA2 1 ILE A 86  ? GLU A 88  ? ILE A 88  GLU A 90  
AA2 2 VAL A 418 ? VAL A 422 ? VAL A 420 VAL A 424 
AA2 3 MET A 292 ? ILE A 297 ? MET A 294 ILE A 299 
AA2 4 GLY A 355 ? LYS A 363 ? GLY A 357 LYS A 365 
AA2 5 SER A 263 ? GLN A 268 ? SER A 265 GLN A 270 
AA2 6 THR A 113 ? VAL A 118 ? THR A 115 VAL A 120 
AA2 7 PHE A 163 ? THR A 167 ? PHE A 165 THR A 169 
AA2 8 LEU A 189 ? LYS A 193 ? LEU A 191 LYS A 195 
AA3 1 VAL A 197 ? PHE A 198 ? VAL A 199 PHE A 200 
AA3 2 ARG A 217 ? LYS A 218 ? ARG A 219 LYS A 220 
AA4 1 THR A 233 ? VAL A 234 ? THR A 235 VAL A 236 
AA4 2 GLN A 250 ? PRO A 251 ? GLN A 252 PRO A 253 
AA5 1 PHE A 381 ? ILE A 382 ? PHE A 383 ILE A 384 
AA5 2 ILE A 400 ? GLU A 401 ? ILE A 402 GLU A 403 
AA6 1 VAL A 481 ? VAL A 483 ? VAL A 483 VAL A 485 
AA6 2 PHE A 488 ? VAL A 490 ? PHE A 490 VAL A 492 
AA7 1 ILE A 495 ? LEU A 498 ? ILE A 497 LEU A 500 
AA7 2 THR A 528 ? GLU A 532 ? THR A 530 GLU A 534 
AA7 3 ALA A 545 ? ARG A 549 ? ALA A 547 ARG A 551 
AA7 4 ALA A 604 ? MET A 606 ? ALA A 606 MET A 608 
AA8 1 VAL A 521 ? ILE A 523 ? VAL A 523 ILE A 525 
AA8 2 LEU A 540 ? TYR A 543 ? LEU A 542 TYR A 545 
AA8 3 ALA A 564 ? ARG A 567 ? ALA A 566 ARG A 569 
AA9 1 VAL A 535 ? ILE A 537 ? VAL A 537 ILE A 539 
AA9 2 HIS A 559 ? VAL A 561 ? HIS A 561 VAL A 563 
AB1 1 SER A 572 ? ALA A 575 ? SER A 574 ALA A 577 
AB1 2 PHE A 596 ? LYS A 599 ? PHE A 598 LYS A 601 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLU A 81  ? N GLU A 83  O ARG A 310 ? O ARG A 312 
AA1 2 3 N THR A 311 ? N THR A 313 O LEU A 320 ? O LEU A 322 
AA2 1 2 N PHE A 87  ? N PHE A 89  O VAL A 422 ? O VAL A 424 
AA2 2 3 O THR A 421 ? O THR A 423 N CYS A 296 ? N CYS A 298 
AA2 3 4 N THR A 295 ? N THR A 297 O VAL A 357 ? O VAL A 359 
AA2 4 5 O PHE A 362 ? O PHE A 364 N ILE A 264 ? N ILE A 266 
AA2 5 6 O VAL A 265 ? O VAL A 267 N VAL A 116 ? N VAL A 118 
AA2 6 7 N LEU A 117 ? N LEU A 119 O VAL A 164 ? O VAL A 166 
AA2 7 8 N PHE A 163 ? N PHE A 165 O HIS A 190 ? O HIS A 192 
AA3 1 2 N VAL A 197 ? N VAL A 199 O LYS A 218 ? O LYS A 220 
AA4 1 2 N VAL A 234 ? N VAL A 236 O GLN A 250 ? O GLN A 252 
AA5 1 2 N PHE A 381 ? N PHE A 383 O GLU A 401 ? O GLU A 403 
AA6 1 2 N VAL A 483 ? N VAL A 485 O PHE A 488 ? O PHE A 490 
AA7 1 2 N ILE A 495 ? N ILE A 497 O LEU A 529 ? O LEU A 531 
AA7 2 3 N ILE A 530 ? N ILE A 532 O ILE A 548 ? O ILE A 550 
AA7 3 4 N THR A 547 ? N THR A 549 O ALA A 604 ? O ALA A 606 
AA8 1 2 N HIS A 522 ? N HIS A 524 O LEU A 540 ? O LEU A 542 
AA8 2 3 N TYR A 543 ? N TYR A 545 O VAL A 566 ? O VAL A 568 
AA9 1 2 N ILE A 536 ? N ILE A 538 O HIS A 559 ? O HIS A 561 
AB1 1 2 N SER A 572 ? N SER A 574 O LYS A 599 ? O LYS A 601 
# 
_pdbx_entry_details.entry_id                   8TG2 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   NH1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ARG 
_pdbx_validate_close_contact.auth_seq_id_1    176 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    801 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.07 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 238 ? ? -115.49 -89.25  
2 1 VAL A 240 ? ? 37.16   41.93   
3 1 ALA A 251 ? ? -125.97 -57.52  
4 1 LYS A 304 ? ? -100.98 74.46   
5 1 PRO A 306 ? ? -76.04  48.84   
6 1 ASP A 348 ? ? -162.47 61.43   
7 1 ARG A 394 ? ? -88.29  49.73   
8 1 SER A 506 ? ? 57.16   -123.76 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     967 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   E 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1  1 O ? A HOH 997  ? 6.08 . 
2  1 O ? A HOH 998  ? 6.32 . 
3  1 O ? A HOH 999  ? 6.38 . 
4  1 O ? A HOH 1000 ? 6.39 . 
5  1 O ? A HOH 1001 ? 6.40 . 
6  1 O ? A HOH 1002 ? 6.45 . 
7  1 O ? A HOH 1003 ? 6.60 . 
8  1 O ? A HOH 1004 ? 6.73 . 
9  1 O ? A HOH 1005 ? 6.82 . 
10 1 O ? A HOH 1006 ? 6.93 . 
11 1 O ? A HOH 1007 ? 7.24 . 
12 1 O ? A HOH 1008 ? 7.34 . 
13 1 O ? A HOH 1009 ? 7.55 . 
14 1 O ? A HOH 1010 ? 7.88 . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
CYS N      N N N 74  
CYS CA     C N R 75  
CYS C      C N N 76  
CYS O      O N N 77  
CYS CB     C N N 78  
CYS SG     S N N 79  
CYS OXT    O N N 80  
CYS H      H N N 81  
CYS H2     H N N 82  
CYS HA     H N N 83  
CYS HB2    H N N 84  
CYS HB3    H N N 85  
CYS HG     H N N 86  
CYS HXT    H N N 87  
GLN N      N N N 88  
GLN CA     C N S 89  
GLN C      C N N 90  
GLN O      O N N 91  
GLN CB     C N N 92  
GLN CG     C N N 93  
GLN CD     C N N 94  
GLN OE1    O N N 95  
GLN NE2    N N N 96  
GLN OXT    O N N 97  
GLN H      H N N 98  
GLN H2     H N N 99  
GLN HA     H N N 100 
GLN HB2    H N N 101 
GLN HB3    H N N 102 
GLN HG2    H N N 103 
GLN HG3    H N N 104 
GLN HE21   H N N 105 
GLN HE22   H N N 106 
GLN HXT    H N N 107 
GLU N      N N N 108 
GLU CA     C N S 109 
GLU C      C N N 110 
GLU O      O N N 111 
GLU CB     C N N 112 
GLU CG     C N N 113 
GLU CD     C N N 114 
GLU OE1    O N N 115 
GLU OE2    O N N 116 
GLU OXT    O N N 117 
GLU H      H N N 118 
GLU H2     H N N 119 
GLU HA     H N N 120 
GLU HB2    H N N 121 
GLU HB3    H N N 122 
GLU HG2    H N N 123 
GLU HG3    H N N 124 
GLU HE2    H N N 125 
GLU HXT    H N N 126 
GLY N      N N N 127 
GLY CA     C N N 128 
GLY C      C N N 129 
GLY O      O N N 130 
GLY OXT    O N N 131 
GLY H      H N N 132 
GLY H2     H N N 133 
GLY HA2    H N N 134 
GLY HA3    H N N 135 
GLY HXT    H N N 136 
HIS N      N N N 137 
HIS CA     C N S 138 
HIS C      C N N 139 
HIS O      O N N 140 
HIS CB     C N N 141 
HIS CG     C Y N 142 
HIS ND1    N Y N 143 
HIS CD2    C Y N 144 
HIS CE1    C Y N 145 
HIS NE2    N Y N 146 
HIS OXT    O N N 147 
HIS H      H N N 148 
HIS H2     H N N 149 
HIS HA     H N N 150 
HIS HB2    H N N 151 
HIS HB3    H N N 152 
HIS HD1    H N N 153 
HIS HD2    H N N 154 
HIS HE1    H N N 155 
HIS HE2    H N N 156 
HIS HXT    H N N 157 
HOH O      O N N 158 
HOH H1     H N N 159 
HOH H2     H N N 160 
ILE N      N N N 161 
ILE CA     C N S 162 
ILE C      C N N 163 
ILE O      O N N 164 
ILE CB     C N S 165 
ILE CG1    C N N 166 
ILE CG2    C N N 167 
ILE CD1    C N N 168 
ILE OXT    O N N 169 
ILE H      H N N 170 
ILE H2     H N N 171 
ILE HA     H N N 172 
ILE HB     H N N 173 
ILE HG12   H N N 174 
ILE HG13   H N N 175 
ILE HG21   H N N 176 
ILE HG22   H N N 177 
ILE HG23   H N N 178 
ILE HD11   H N N 179 
ILE HD12   H N N 180 
ILE HD13   H N N 181 
ILE HXT    H N N 182 
LEU N      N N N 183 
LEU CA     C N S 184 
LEU C      C N N 185 
LEU O      O N N 186 
LEU CB     C N N 187 
LEU CG     C N N 188 
LEU CD1    C N N 189 
LEU CD2    C N N 190 
LEU OXT    O N N 191 
LEU H      H N N 192 
LEU H2     H N N 193 
LEU HA     H N N 194 
LEU HB2    H N N 195 
LEU HB3    H N N 196 
LEU HG     H N N 197 
LEU HD11   H N N 198 
LEU HD12   H N N 199 
LEU HD13   H N N 200 
LEU HD21   H N N 201 
LEU HD22   H N N 202 
LEU HD23   H N N 203 
LEU HXT    H N N 204 
LYS N      N N N 205 
LYS CA     C N S 206 
LYS C      C N N 207 
LYS O      O N N 208 
LYS CB     C N N 209 
LYS CG     C N N 210 
LYS CD     C N N 211 
LYS CE     C N N 212 
LYS NZ     N N N 213 
LYS OXT    O N N 214 
LYS H      H N N 215 
LYS H2     H N N 216 
LYS HA     H N N 217 
LYS HB2    H N N 218 
LYS HB3    H N N 219 
LYS HG2    H N N 220 
LYS HG3    H N N 221 
LYS HD2    H N N 222 
LYS HD3    H N N 223 
LYS HE2    H N N 224 
LYS HE3    H N N 225 
LYS HZ1    H N N 226 
LYS HZ2    H N N 227 
LYS HZ3    H N N 228 
LYS HXT    H N N 229 
MET N      N N N 230 
MET CA     C N S 231 
MET C      C N N 232 
MET O      O N N 233 
MET CB     C N N 234 
MET CG     C N N 235 
MET SD     S N N 236 
MET CE     C N N 237 
MET OXT    O N N 238 
MET H      H N N 239 
MET H2     H N N 240 
MET HA     H N N 241 
MET HB2    H N N 242 
MET HB3    H N N 243 
MET HG2    H N N 244 
MET HG3    H N N 245 
MET HE1    H N N 246 
MET HE2    H N N 247 
MET HE3    H N N 248 
MET HXT    H N N 249 
PHE N      N N N 250 
PHE CA     C N S 251 
PHE C      C N N 252 
PHE O      O N N 253 
PHE CB     C N N 254 
PHE CG     C Y N 255 
PHE CD1    C Y N 256 
PHE CD2    C Y N 257 
PHE CE1    C Y N 258 
PHE CE2    C Y N 259 
PHE CZ     C Y N 260 
PHE OXT    O N N 261 
PHE H      H N N 262 
PHE H2     H N N 263 
PHE HA     H N N 264 
PHE HB2    H N N 265 
PHE HB3    H N N 266 
PHE HD1    H N N 267 
PHE HD2    H N N 268 
PHE HE1    H N N 269 
PHE HE2    H N N 270 
PHE HZ     H N N 271 
PHE HXT    H N N 272 
POP P1     P N N 273 
POP O1     O N N 274 
POP O2     O N N 275 
POP O3     O N N 276 
POP O      O N N 277 
POP P2     P N N 278 
POP O4     O N N 279 
POP O5     O N N 280 
POP O6     O N N 281 
POP HO2    H N N 282 
POP HO5    H N N 283 
PRO N      N N N 284 
PRO CA     C N S 285 
PRO C      C N N 286 
PRO O      O N N 287 
PRO CB     C N N 288 
PRO CG     C N N 289 
PRO CD     C N N 290 
PRO OXT    O N N 291 
PRO H      H N N 292 
PRO HA     H N N 293 
PRO HB2    H N N 294 
PRO HB3    H N N 295 
PRO HG2    H N N 296 
PRO HG3    H N N 297 
PRO HD2    H N N 298 
PRO HD3    H N N 299 
PRO HXT    H N N 300 
SER N      N N N 301 
SER CA     C N S 302 
SER C      C N N 303 
SER O      O N N 304 
SER CB     C N N 305 
SER OG     O N N 306 
SER OXT    O N N 307 
SER H      H N N 308 
SER H2     H N N 309 
SER HA     H N N 310 
SER HB2    H N N 311 
SER HB3    H N N 312 
SER HG     H N N 313 
SER HXT    H N N 314 
THR N      N N N 315 
THR CA     C N S 316 
THR C      C N N 317 
THR O      O N N 318 
THR CB     C N R 319 
THR OG1    O N N 320 
THR CG2    C N N 321 
THR OXT    O N N 322 
THR H      H N N 323 
THR H2     H N N 324 
THR HA     H N N 325 
THR HB     H N N 326 
THR HG1    H N N 327 
THR HG21   H N N 328 
THR HG22   H N N 329 
THR HG23   H N N 330 
THR HXT    H N N 331 
TRP N      N N N 332 
TRP CA     C N S 333 
TRP C      C N N 334 
TRP O      O N N 335 
TRP CB     C N N 336 
TRP CG     C Y N 337 
TRP CD1    C Y N 338 
TRP CD2    C Y N 339 
TRP NE1    N Y N 340 
TRP CE2    C Y N 341 
TRP CE3    C Y N 342 
TRP CZ2    C Y N 343 
TRP CZ3    C Y N 344 
TRP CH2    C Y N 345 
TRP OXT    O N N 346 
TRP H      H N N 347 
TRP H2     H N N 348 
TRP HA     H N N 349 
TRP HB2    H N N 350 
TRP HB3    H N N 351 
TRP HD1    H N N 352 
TRP HE1    H N N 353 
TRP HE3    H N N 354 
TRP HZ2    H N N 355 
TRP HZ3    H N N 356 
TRP HH2    H N N 357 
TRP HXT    H N N 358 
TYR N      N N N 359 
TYR CA     C N S 360 
TYR C      C N N 361 
TYR O      O N N 362 
TYR CB     C N N 363 
TYR CG     C Y N 364 
TYR CD1    C Y N 365 
TYR CD2    C Y N 366 
TYR CE1    C Y N 367 
TYR CE2    C Y N 368 
TYR CZ     C Y N 369 
TYR OH     O N N 370 
TYR OXT    O N N 371 
TYR H      H N N 372 
TYR H2     H N N 373 
TYR HA     H N N 374 
TYR HB2    H N N 375 
TYR HB3    H N N 376 
TYR HD1    H N N 377 
TYR HD2    H N N 378 
TYR HE1    H N N 379 
TYR HE2    H N N 380 
TYR HH     H N N 381 
TYR HXT    H N N 382 
UPG N1     N N N 383 
UPG C2     C N N 384 
UPG N3     N N N 385 
UPG C4     C N N 386 
UPG C5     C N N 387 
UPG C6     C N N 388 
UPG O2     O N N 389 
UPG O4     O N N 390 
UPG C1C    C N R 391 
UPG C2C    C N R 392 
UPG O2C    O N N 393 
UPG C3C    C N S 394 
UPG C4C    C N R 395 
UPG O4C    O N N 396 
UPG O3C    O N N 397 
UPG C5C    C N N 398 
UPG O5C    O N N 399 
UPG PA     P N N 400 
UPG O1A    O N N 401 
UPG O2A    O N N 402 
UPG O3A    O N N 403 
UPG PB     P N N 404 
UPG O1B    O N N 405 
UPG O2B    O N N 406 
UPG O3B    O N N 407 
UPG "C1'"  C N R 408 
UPG "C2'"  C N R 409 
UPG "C3'"  C N S 410 
UPG "C4'"  C N S 411 
UPG "C5'"  C N R 412 
UPG "C6'"  C N N 413 
UPG "O2'"  O N N 414 
UPG "O3'"  O N N 415 
UPG "O4'"  O N N 416 
UPG "O5'"  O N N 417 
UPG "O6'"  O N N 418 
UPG HN3    H N N 419 
UPG H5     H N N 420 
UPG H6     H N N 421 
UPG H1C    H N N 422 
UPG H2C    H N N 423 
UPG HO2C   H N N 424 
UPG H3C    H N N 425 
UPG H4C    H N N 426 
UPG HO3C   H N N 427 
UPG H5C1   H N N 428 
UPG H5C2   H N N 429 
UPG HOA2   H N N 430 
UPG HOB2   H N N 431 
UPG "H1'"  H N N 432 
UPG "H2'"  H N N 433 
UPG "H3'"  H N N 434 
UPG "H4'"  H N N 435 
UPG "H5'"  H N N 436 
UPG "H6'1" H N N 437 
UPG "H6'2" H N N 438 
UPG "HO2'" H N N 439 
UPG "HO3'" H N N 440 
UPG "HO4'" H N N 441 
UPG "HO6'" H N N 442 
VAL N      N N N 443 
VAL CA     C N S 444 
VAL C      C N N 445 
VAL O      O N N 446 
VAL CB     C N N 447 
VAL CG1    C N N 448 
VAL CG2    C N N 449 
VAL OXT    O N N 450 
VAL H      H N N 451 
VAL H2     H N N 452 
VAL HA     H N N 453 
VAL HB     H N N 454 
VAL HG11   H N N 455 
VAL HG12   H N N 456 
VAL HG13   H N N 457 
VAL HG21   H N N 458 
VAL HG22   H N N 459 
VAL HG23   H N N 460 
VAL HXT    H N N 461 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
GLN N     CA     sing N N 83  
GLN N     H      sing N N 84  
GLN N     H2     sing N N 85  
GLN CA    C      sing N N 86  
GLN CA    CB     sing N N 87  
GLN CA    HA     sing N N 88  
GLN C     O      doub N N 89  
GLN C     OXT    sing N N 90  
GLN CB    CG     sing N N 91  
GLN CB    HB2    sing N N 92  
GLN CB    HB3    sing N N 93  
GLN CG    CD     sing N N 94  
GLN CG    HG2    sing N N 95  
GLN CG    HG3    sing N N 96  
GLN CD    OE1    doub N N 97  
GLN CD    NE2    sing N N 98  
GLN NE2   HE21   sing N N 99  
GLN NE2   HE22   sing N N 100 
GLN OXT   HXT    sing N N 101 
GLU N     CA     sing N N 102 
GLU N     H      sing N N 103 
GLU N     H2     sing N N 104 
GLU CA    C      sing N N 105 
GLU CA    CB     sing N N 106 
GLU CA    HA     sing N N 107 
GLU C     O      doub N N 108 
GLU C     OXT    sing N N 109 
GLU CB    CG     sing N N 110 
GLU CB    HB2    sing N N 111 
GLU CB    HB3    sing N N 112 
GLU CG    CD     sing N N 113 
GLU CG    HG2    sing N N 114 
GLU CG    HG3    sing N N 115 
GLU CD    OE1    doub N N 116 
GLU CD    OE2    sing N N 117 
GLU OE2   HE2    sing N N 118 
GLU OXT   HXT    sing N N 119 
GLY N     CA     sing N N 120 
GLY N     H      sing N N 121 
GLY N     H2     sing N N 122 
GLY CA    C      sing N N 123 
GLY CA    HA2    sing N N 124 
GLY CA    HA3    sing N N 125 
GLY C     O      doub N N 126 
GLY C     OXT    sing N N 127 
GLY OXT   HXT    sing N N 128 
HIS N     CA     sing N N 129 
HIS N     H      sing N N 130 
HIS N     H2     sing N N 131 
HIS CA    C      sing N N 132 
HIS CA    CB     sing N N 133 
HIS CA    HA     sing N N 134 
HIS C     O      doub N N 135 
HIS C     OXT    sing N N 136 
HIS CB    CG     sing N N 137 
HIS CB    HB2    sing N N 138 
HIS CB    HB3    sing N N 139 
HIS CG    ND1    sing Y N 140 
HIS CG    CD2    doub Y N 141 
HIS ND1   CE1    doub Y N 142 
HIS ND1   HD1    sing N N 143 
HIS CD2   NE2    sing Y N 144 
HIS CD2   HD2    sing N N 145 
HIS CE1   NE2    sing Y N 146 
HIS CE1   HE1    sing N N 147 
HIS NE2   HE2    sing N N 148 
HIS OXT   HXT    sing N N 149 
HOH O     H1     sing N N 150 
HOH O     H2     sing N N 151 
ILE N     CA     sing N N 152 
ILE N     H      sing N N 153 
ILE N     H2     sing N N 154 
ILE CA    C      sing N N 155 
ILE CA    CB     sing N N 156 
ILE CA    HA     sing N N 157 
ILE C     O      doub N N 158 
ILE C     OXT    sing N N 159 
ILE CB    CG1    sing N N 160 
ILE CB    CG2    sing N N 161 
ILE CB    HB     sing N N 162 
ILE CG1   CD1    sing N N 163 
ILE CG1   HG12   sing N N 164 
ILE CG1   HG13   sing N N 165 
ILE CG2   HG21   sing N N 166 
ILE CG2   HG22   sing N N 167 
ILE CG2   HG23   sing N N 168 
ILE CD1   HD11   sing N N 169 
ILE CD1   HD12   sing N N 170 
ILE CD1   HD13   sing N N 171 
ILE OXT   HXT    sing N N 172 
LEU N     CA     sing N N 173 
LEU N     H      sing N N 174 
LEU N     H2     sing N N 175 
LEU CA    C      sing N N 176 
LEU CA    CB     sing N N 177 
LEU CA    HA     sing N N 178 
LEU C     O      doub N N 179 
LEU C     OXT    sing N N 180 
LEU CB    CG     sing N N 181 
LEU CB    HB2    sing N N 182 
LEU CB    HB3    sing N N 183 
LEU CG    CD1    sing N N 184 
LEU CG    CD2    sing N N 185 
LEU CG    HG     sing N N 186 
LEU CD1   HD11   sing N N 187 
LEU CD1   HD12   sing N N 188 
LEU CD1   HD13   sing N N 189 
LEU CD2   HD21   sing N N 190 
LEU CD2   HD22   sing N N 191 
LEU CD2   HD23   sing N N 192 
LEU OXT   HXT    sing N N 193 
LYS N     CA     sing N N 194 
LYS N     H      sing N N 195 
LYS N     H2     sing N N 196 
LYS CA    C      sing N N 197 
LYS CA    CB     sing N N 198 
LYS CA    HA     sing N N 199 
LYS C     O      doub N N 200 
LYS C     OXT    sing N N 201 
LYS CB    CG     sing N N 202 
LYS CB    HB2    sing N N 203 
LYS CB    HB3    sing N N 204 
LYS CG    CD     sing N N 205 
LYS CG    HG2    sing N N 206 
LYS CG    HG3    sing N N 207 
LYS CD    CE     sing N N 208 
LYS CD    HD2    sing N N 209 
LYS CD    HD3    sing N N 210 
LYS CE    NZ     sing N N 211 
LYS CE    HE2    sing N N 212 
LYS CE    HE3    sing N N 213 
LYS NZ    HZ1    sing N N 214 
LYS NZ    HZ2    sing N N 215 
LYS NZ    HZ3    sing N N 216 
LYS OXT   HXT    sing N N 217 
MET N     CA     sing N N 218 
MET N     H      sing N N 219 
MET N     H2     sing N N 220 
MET CA    C      sing N N 221 
MET CA    CB     sing N N 222 
MET CA    HA     sing N N 223 
MET C     O      doub N N 224 
MET C     OXT    sing N N 225 
MET CB    CG     sing N N 226 
MET CB    HB2    sing N N 227 
MET CB    HB3    sing N N 228 
MET CG    SD     sing N N 229 
MET CG    HG2    sing N N 230 
MET CG    HG3    sing N N 231 
MET SD    CE     sing N N 232 
MET CE    HE1    sing N N 233 
MET CE    HE2    sing N N 234 
MET CE    HE3    sing N N 235 
MET OXT   HXT    sing N N 236 
PHE N     CA     sing N N 237 
PHE N     H      sing N N 238 
PHE N     H2     sing N N 239 
PHE CA    C      sing N N 240 
PHE CA    CB     sing N N 241 
PHE CA    HA     sing N N 242 
PHE C     O      doub N N 243 
PHE C     OXT    sing N N 244 
PHE CB    CG     sing N N 245 
PHE CB    HB2    sing N N 246 
PHE CB    HB3    sing N N 247 
PHE CG    CD1    doub Y N 248 
PHE CG    CD2    sing Y N 249 
PHE CD1   CE1    sing Y N 250 
PHE CD1   HD1    sing N N 251 
PHE CD2   CE2    doub Y N 252 
PHE CD2   HD2    sing N N 253 
PHE CE1   CZ     doub Y N 254 
PHE CE1   HE1    sing N N 255 
PHE CE2   CZ     sing Y N 256 
PHE CE2   HE2    sing N N 257 
PHE CZ    HZ     sing N N 258 
PHE OXT   HXT    sing N N 259 
POP P1    O1     doub N N 260 
POP P1    O2     sing N N 261 
POP P1    O3     sing N N 262 
POP P1    O      sing N N 263 
POP O2    HO2    sing N N 264 
POP O     P2     sing N N 265 
POP P2    O4     doub N N 266 
POP P2    O5     sing N N 267 
POP P2    O6     sing N N 268 
POP O5    HO5    sing N N 269 
PRO N     CA     sing N N 270 
PRO N     CD     sing N N 271 
PRO N     H      sing N N 272 
PRO CA    C      sing N N 273 
PRO CA    CB     sing N N 274 
PRO CA    HA     sing N N 275 
PRO C     O      doub N N 276 
PRO C     OXT    sing N N 277 
PRO CB    CG     sing N N 278 
PRO CB    HB2    sing N N 279 
PRO CB    HB3    sing N N 280 
PRO CG    CD     sing N N 281 
PRO CG    HG2    sing N N 282 
PRO CG    HG3    sing N N 283 
PRO CD    HD2    sing N N 284 
PRO CD    HD3    sing N N 285 
PRO OXT   HXT    sing N N 286 
SER N     CA     sing N N 287 
SER N     H      sing N N 288 
SER N     H2     sing N N 289 
SER CA    C      sing N N 290 
SER CA    CB     sing N N 291 
SER CA    HA     sing N N 292 
SER C     O      doub N N 293 
SER C     OXT    sing N N 294 
SER CB    OG     sing N N 295 
SER CB    HB2    sing N N 296 
SER CB    HB3    sing N N 297 
SER OG    HG     sing N N 298 
SER OXT   HXT    sing N N 299 
THR N     CA     sing N N 300 
THR N     H      sing N N 301 
THR N     H2     sing N N 302 
THR CA    C      sing N N 303 
THR CA    CB     sing N N 304 
THR CA    HA     sing N N 305 
THR C     O      doub N N 306 
THR C     OXT    sing N N 307 
THR CB    OG1    sing N N 308 
THR CB    CG2    sing N N 309 
THR CB    HB     sing N N 310 
THR OG1   HG1    sing N N 311 
THR CG2   HG21   sing N N 312 
THR CG2   HG22   sing N N 313 
THR CG2   HG23   sing N N 314 
THR OXT   HXT    sing N N 315 
TRP N     CA     sing N N 316 
TRP N     H      sing N N 317 
TRP N     H2     sing N N 318 
TRP CA    C      sing N N 319 
TRP CA    CB     sing N N 320 
TRP CA    HA     sing N N 321 
TRP C     O      doub N N 322 
TRP C     OXT    sing N N 323 
TRP CB    CG     sing N N 324 
TRP CB    HB2    sing N N 325 
TRP CB    HB3    sing N N 326 
TRP CG    CD1    doub Y N 327 
TRP CG    CD2    sing Y N 328 
TRP CD1   NE1    sing Y N 329 
TRP CD1   HD1    sing N N 330 
TRP CD2   CE2    doub Y N 331 
TRP CD2   CE3    sing Y N 332 
TRP NE1   CE2    sing Y N 333 
TRP NE1   HE1    sing N N 334 
TRP CE2   CZ2    sing Y N 335 
TRP CE3   CZ3    doub Y N 336 
TRP CE3   HE3    sing N N 337 
TRP CZ2   CH2    doub Y N 338 
TRP CZ2   HZ2    sing N N 339 
TRP CZ3   CH2    sing Y N 340 
TRP CZ3   HZ3    sing N N 341 
TRP CH2   HH2    sing N N 342 
TRP OXT   HXT    sing N N 343 
TYR N     CA     sing N N 344 
TYR N     H      sing N N 345 
TYR N     H2     sing N N 346 
TYR CA    C      sing N N 347 
TYR CA    CB     sing N N 348 
TYR CA    HA     sing N N 349 
TYR C     O      doub N N 350 
TYR C     OXT    sing N N 351 
TYR CB    CG     sing N N 352 
TYR CB    HB2    sing N N 353 
TYR CB    HB3    sing N N 354 
TYR CG    CD1    doub Y N 355 
TYR CG    CD2    sing Y N 356 
TYR CD1   CE1    sing Y N 357 
TYR CD1   HD1    sing N N 358 
TYR CD2   CE2    doub Y N 359 
TYR CD2   HD2    sing N N 360 
TYR CE1   CZ     doub Y N 361 
TYR CE1   HE1    sing N N 362 
TYR CE2   CZ     sing Y N 363 
TYR CE2   HE2    sing N N 364 
TYR CZ    OH     sing N N 365 
TYR OH    HH     sing N N 366 
TYR OXT   HXT    sing N N 367 
UPG N1    C2     sing N N 368 
UPG N1    C6     sing N N 369 
UPG N1    C1C    sing N N 370 
UPG C2    N3     sing N N 371 
UPG C2    O2     doub N N 372 
UPG N3    C4     sing N N 373 
UPG N3    HN3    sing N N 374 
UPG C4    C5     sing N N 375 
UPG C4    O4     doub N N 376 
UPG C5    C6     doub N N 377 
UPG C5    H5     sing N N 378 
UPG C6    H6     sing N N 379 
UPG C1C   C2C    sing N N 380 
UPG C1C   O4C    sing N N 381 
UPG C1C   H1C    sing N N 382 
UPG C2C   O2C    sing N N 383 
UPG C2C   C3C    sing N N 384 
UPG C2C   H2C    sing N N 385 
UPG O2C   HO2C   sing N N 386 
UPG C3C   C4C    sing N N 387 
UPG C3C   O3C    sing N N 388 
UPG C3C   H3C    sing N N 389 
UPG C4C   O4C    sing N N 390 
UPG C4C   C5C    sing N N 391 
UPG C4C   H4C    sing N N 392 
UPG O3C   HO3C   sing N N 393 
UPG C5C   O5C    sing N N 394 
UPG C5C   H5C1   sing N N 395 
UPG C5C   H5C2   sing N N 396 
UPG O5C   PA     sing N N 397 
UPG PA    O1A    doub N N 398 
UPG PA    O2A    sing N N 399 
UPG PA    O3A    sing N N 400 
UPG O2A   HOA2   sing N N 401 
UPG O3A   PB     sing N N 402 
UPG PB    O1B    doub N N 403 
UPG PB    O2B    sing N N 404 
UPG PB    O3B    sing N N 405 
UPG O2B   HOB2   sing N N 406 
UPG O3B   "C1'"  sing N N 407 
UPG "C1'" "C2'"  sing N N 408 
UPG "C1'" "O5'"  sing N N 409 
UPG "C1'" "H1'"  sing N N 410 
UPG "C2'" "C3'"  sing N N 411 
UPG "C2'" "O2'"  sing N N 412 
UPG "C2'" "H2'"  sing N N 413 
UPG "C3'" "C4'"  sing N N 414 
UPG "C3'" "O3'"  sing N N 415 
UPG "C3'" "H3'"  sing N N 416 
UPG "C4'" "C5'"  sing N N 417 
UPG "C4'" "O4'"  sing N N 418 
UPG "C4'" "H4'"  sing N N 419 
UPG "C5'" "C6'"  sing N N 420 
UPG "C5'" "O5'"  sing N N 421 
UPG "C5'" "H5'"  sing N N 422 
UPG "C6'" "O6'"  sing N N 423 
UPG "C6'" "H6'1" sing N N 424 
UPG "C6'" "H6'2" sing N N 425 
UPG "O2'" "HO2'" sing N N 426 
UPG "O3'" "HO3'" sing N N 427 
UPG "O4'" "HO4'" sing N N 428 
UPG "O6'" "HO6'" sing N N 429 
VAL N     CA     sing N N 430 
VAL N     H      sing N N 431 
VAL N     H2     sing N N 432 
VAL CA    C      sing N N 433 
VAL CA    CB     sing N N 434 
VAL CA    HA     sing N N 435 
VAL C     O      doub N N 436 
VAL C     OXT    sing N N 437 
VAL CB    CG1    sing N N 438 
VAL CB    CG2    sing N N 439 
VAL CB    HB     sing N N 440 
VAL CG1   HG11   sing N N 441 
VAL CG1   HG12   sing N N 442 
VAL CG1   HG13   sing N N 443 
VAL CG2   HG21   sing N N 444 
VAL CG2   HG22   sing N N 445 
VAL CG2   HG23   sing N N 446 
VAL OXT   HXT    sing N N 447 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'German Research Foundation (DFG)' Germany          'FE 1510/2-1'        1 
'European Union (EU)'              'European Union' 'EU FP7, GA. 608295' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3OH4 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8TG2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009338 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002623 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008203 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.017039 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
P 15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491 68.164 1.115   
S 16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N     . ASN A 1 1   ? -0.911  19.752  59.418 1.00 116.75 ? 3    ASN A N     1 ? 
ATOM   2    C CA    . ASN A 1 1   ? 0.549   19.983  59.699 1.00 121.13 ? 3    ASN A CA    1 ? 
ATOM   3    C C     . ASN A 1 1   ? 0.916   21.455  59.502 1.00 116.13 ? 3    ASN A C     1 ? 
ATOM   4    O O     . ASN A 1 1   ? 1.519   22.048  60.398 1.00 104.71 ? 3    ASN A O     1 ? 
ATOM   5    C CB    . ASN A 1 1   ? 1.435   19.066  58.850 1.00 117.92 ? 3    ASN A CB    1 ? 
ATOM   6    C CG    . ASN A 1 1   ? 2.905   19.199  59.184 1.00 120.58 ? 3    ASN A CG    1 ? 
ATOM   7    O OD1   . ASN A 1 1   ? 3.270   19.816  60.185 1.00 117.47 ? 3    ASN A OD1   1 ? 
ATOM   8    N ND2   . ASN A 1 1   ? 3.755   18.622  58.349 1.00 114.06 ? 3    ASN A ND2   1 ? 
ATOM   9    N N     . PRO A 1 2   ? 0.608   22.087  58.339 1.00 117.46 ? 4    PRO A N     1 ? 
ATOM   10   C CA    . PRO A 1 2   ? 1.003   23.474  58.111 1.00 113.91 ? 4    PRO A CA    1 ? 
ATOM   11   C C     . PRO A 1 2   ? 0.063   24.442  58.835 1.00 103.90 ? 4    PRO A C     1 ? 
ATOM   12   O O     . PRO A 1 2   ? -1.062  24.621  58.397 1.00 102.39 ? 4    PRO A O     1 ? 
ATOM   13   C CB    . PRO A 1 2   ? 0.916   23.639  56.589 1.00 105.41 ? 4    PRO A CB    1 ? 
ATOM   14   C CG    . PRO A 1 2   ? -0.179  22.687  56.192 1.00 112.48 ? 4    PRO A CG    1 ? 
ATOM   15   C CD    . PRO A 1 2   ? -0.109  21.532  57.176 1.00 112.97 ? 4    PRO A CD    1 ? 
ATOM   16   N N     . SER A 1 3   ? 0.560   25.054  59.908 1.00 95.46  ? 5    SER A N     1 ? 
ATOM   17   C CA    . SER A 1 3   ? -0.210  26.072  60.661 1.00 95.23  ? 5    SER A CA    1 ? 
ATOM   18   C C     . SER A 1 3   ? -0.164  27.390  59.896 1.00 98.26  ? 5    SER A C     1 ? 
ATOM   19   O O     . SER A 1 3   ? 0.633   27.506  58.954 1.00 112.45 ? 5    SER A O     1 ? 
ATOM   20   C CB    . SER A 1 3   ? 0.302   26.229  62.058 1.00 99.62  ? 5    SER A CB    1 ? 
ATOM   21   O OG    . SER A 1 3   ? 1.370   27.168  62.116 1.00 96.50  ? 5    SER A OG    1 ? 
ATOM   22   N N     . ASN A 1 4   ? -0.997  28.345  60.289 1.00 100.78 ? 6    ASN A N     1 ? 
ATOM   23   C CA    . ASN A 1 4   ? -1.045  29.681  59.643 1.00 103.83 ? 6    ASN A CA    1 ? 
ATOM   24   C C     . ASN A 1 4   ? 0.243   30.456  59.922 1.00 108.52 ? 6    ASN A C     1 ? 
ATOM   25   O O     . ASN A 1 4   ? 0.650   31.237  59.050 1.00 122.05 ? 6    ASN A O     1 ? 
ATOM   26   C CB    . ASN A 1 4   ? -2.253  30.479  60.113 1.00 104.94 ? 6    ASN A CB    1 ? 
ATOM   27   C CG    . ASN A 1 4   ? -3.533  30.010  59.455 1.00 114.26 ? 6    ASN A CG    1 ? 
ATOM   28   O OD1   . ASN A 1 4   ? -3.678  28.832  59.125 1.00 108.24 ? 6    ASN A OD1   1 ? 
ATOM   29   N ND2   . ASN A 1 4   ? -4.466  30.928  59.245 1.00 109.13 ? 6    ASN A ND2   1 ? 
ATOM   30   N N     . SER A 1 5   ? 0.850   30.256  61.090 1.00 108.27 ? 7    SER A N     1 ? 
ATOM   31   C CA    . SER A 1 5   ? 2.114   30.932  61.478 1.00 107.52 ? 7    SER A CA    1 ? 
ATOM   32   C C     . SER A 1 5   ? 3.218   30.525  60.496 1.00 110.45 ? 7    SER A C     1 ? 
ATOM   33   O O     . SER A 1 5   ? 3.882   31.423  59.943 1.00 115.79 ? 7    SER A O     1 ? 
ATOM   34   C CB    . SER A 1 5   ? 2.482   30.616  62.900 1.00 99.97  ? 7    SER A CB    1 ? 
ATOM   35   O OG    . SER A 1 5   ? 3.467   31.494  63.381 1.00 103.51 ? 7    SER A OG    1 ? 
ATOM   36   N N     . ASN A 1 6   ? 3.377   29.223  60.262 1.00 105.72 ? 8    ASN A N     1 ? 
ATOM   37   C CA    . ASN A 1 6   ? 4.416   28.684  59.348 1.00 101.25 ? 8    ASN A CA    1 ? 
ATOM   38   C C     . ASN A 1 6   ? 4.136   29.126  57.912 1.00 101.55 ? 8    ASN A C     1 ? 
ATOM   39   O O     . ASN A 1 6   ? 5.111   29.301  57.158 1.00 103.58 ? 8    ASN A O     1 ? 
ATOM   40   C CB    . ASN A 1 6   ? 4.497   27.162  59.419 1.00 107.51 ? 8    ASN A CB    1 ? 
ATOM   41   C CG    . ASN A 1 6   ? 4.929   26.662  60.781 1.00 104.48 ? 8    ASN A CG    1 ? 
ATOM   42   O OD1   . ASN A 1 6   ? 5.510   27.405  61.569 1.00 106.83 ? 8    ASN A OD1   1 ? 
ATOM   43   N ND2   . ASN A 1 6   ? 4.647   25.404  61.071 1.00 96.29  ? 8    ASN A ND2   1 ? 
ATOM   44   N N     . LEU A 1 7   ? 2.866   29.273  57.538 1.00 97.78  ? 9    LEU A N     1 ? 
ATOM   45   C CA    . LEU A 1 7   ? 2.500   29.729  56.173 1.00 98.96  ? 9    LEU A CA    1 ? 
ATOM   46   C C     . LEU A 1 7   ? 2.910   31.183  55.986 1.00 95.11  ? 9    LEU A C     1 ? 
ATOM   47   O O     . LEU A 1 7   ? 3.375   31.503  54.876 1.00 95.08  ? 9    LEU A O     1 ? 
ATOM   48   C CB    . LEU A 1 7   ? 0.995   29.577  55.950 1.00 104.06 ? 9    LEU A CB    1 ? 
ATOM   49   C CG    . LEU A 1 7   ? 0.583   28.382  55.092 1.00 104.44 ? 9    LEU A CG    1 ? 
ATOM   50   C CD1   . LEU A 1 7   ? 1.260   27.100  55.559 1.00 97.71  ? 9    LEU A CD1   1 ? 
ATOM   51   C CD2   . LEU A 1 7   ? -0.929  28.228  55.095 1.00 99.99  ? 9    LEU A CD2   1 ? 
ATOM   52   N N     . GLN A 1 8   ? 2.706   32.019  57.008 1.00 93.25  ? 10   GLN A N     1 ? 
ATOM   53   C CA    . GLN A 1 8   ? 3.131   33.446  56.980 1.00 91.93  ? 10   GLN A CA    1 ? 
ATOM   54   C C     . GLN A 1 8   ? 4.663   33.487  56.907 1.00 81.63  ? 10   GLN A C     1 ? 
ATOM   55   O O     . GLN A 1 8   ? 5.192   34.247  56.090 1.00 81.85  ? 10   GLN A O     1 ? 
ATOM   56   C CB    . GLN A 1 8   ? 2.581   34.200  58.196 1.00 89.45  ? 10   GLN A CB    1 ? 
ATOM   57   C CG    . GLN A 1 8   ? 3.151   35.601  58.360 1.00 90.74  ? 10   GLN A CG    1 ? 
ATOM   58   C CD    . GLN A 1 8   ? 2.662   36.562  57.303 1.00 93.47  ? 10   GLN A CD    1 ? 
ATOM   59   O OE1   . GLN A 1 8   ? 1.582   36.412  56.737 1.00 98.25  ? 10   GLN A OE1   1 ? 
ATOM   60   N NE2   . GLN A 1 8   ? 3.458   37.585  57.032 1.00 95.96  ? 10   GLN A NE2   1 ? 
ATOM   61   N N     . ALA A 1 9   ? 5.339   32.668  57.709 1.00 74.80  ? 11   ALA A N     1 ? 
ATOM   62   C CA    . ALA A 1 9   ? 6.816   32.598  57.735 1.00 80.79  ? 11   ALA A CA    1 ? 
ATOM   63   C C     . ALA A 1 9   ? 7.343   32.251  56.339 1.00 84.25  ? 11   ALA A C     1 ? 
ATOM   64   O O     . ALA A 1 9   ? 8.307   32.898  55.897 1.00 85.24  ? 11   ALA A O     1 ? 
ATOM   65   C CB    . ALA A 1 9   ? 7.292   31.592  58.755 1.00 77.17  ? 11   ALA A CB    1 ? 
ATOM   66   N N     . LEU A 1 10  ? 6.744   31.259  55.682 1.00 87.47  ? 12   LEU A N     1 ? 
ATOM   67   C CA    . LEU A 1 10  ? 7.164   30.837  54.326 1.00 85.72  ? 12   LEU A CA    1 ? 
ATOM   68   C C     . LEU A 1 10  ? 6.891   31.963  53.332 1.00 85.91  ? 12   LEU A C     1 ? 
ATOM   69   O O     . LEU A 1 10  ? 7.746   32.204  52.475 1.00 82.92  ? 12   LEU A O     1 ? 
ATOM   70   C CB    . LEU A 1 10  ? 6.423   29.572  53.903 1.00 91.21  ? 12   LEU A CB    1 ? 
ATOM   71   C CG    . LEU A 1 10  ? 6.909   29.005  52.573 1.00 89.64  ? 12   LEU A CG    1 ? 
ATOM   72   C CD1   . LEU A 1 10  ? 8.174   28.191  52.779 1.00 94.16  ? 12   LEU A CD1   1 ? 
ATOM   73   C CD2   . LEU A 1 10  ? 5.823   28.175  51.905 1.00 91.41  ? 12   LEU A CD2   1 ? 
ATOM   74   N N     . ARG A 1 11  ? 5.746   32.631  53.445 1.00 85.79  ? 13   ARG A N     1 ? 
ATOM   75   C CA    . ARG A 1 11  ? 5.419   33.763  52.547 1.00 85.42  ? 13   ARG A CA    1 ? 
ATOM   76   C C     . ARG A 1 11  ? 6.485   34.853  52.670 1.00 80.00  ? 13   ARG A C     1 ? 
ATOM   77   O O     . ARG A 1 11  ? 6.946   35.338  51.625 1.00 82.00  ? 13   ARG A O     1 ? 
ATOM   78   C CB    . ARG A 1 11  ? 4.042   34.322  52.890 1.00 89.43  ? 13   ARG A CB    1 ? 
ATOM   79   C CG    . ARG A 1 11  ? 3.646   35.555  52.093 1.00 93.13  ? 13   ARG A CG    1 ? 
ATOM   80   C CD    . ARG A 1 11  ? 2.428   36.212  52.714 1.00 91.85  ? 13   ARG A CD    1 ? 
ATOM   81   N NE    . ARG A 1 11  ? 1.953   37.344  51.934 1.00 89.63  ? 13   ARG A NE    1 ? 
ATOM   82   C CZ    . ARG A 1 11  ? 0.971   38.156  52.302 1.00 85.04  ? 13   ARG A CZ    1 ? 
ATOM   83   N NH1   . ARG A 1 11  ? 0.333   37.966  53.446 1.00 91.65  ? 13   ARG A NH1   1 ? 
ATOM   84   N NH2   . ARG A 1 11  ? 0.629   39.161  51.518 1.00 81.69  ? 13   ARG A NH2   1 ? 
ATOM   85   N N     . GLU A 1 12  ? 6.832   35.231  53.896 1.00 81.74  ? 14   GLU A N     1 ? 
ATOM   86   C CA    . GLU A 1 12  ? 7.856   36.275  54.154 1.00 86.64  ? 14   GLU A CA    1 ? 
ATOM   87   C C     . GLU A 1 12  ? 9.195   35.800  53.572 1.00 84.94  ? 14   GLU A C     1 ? 
ATOM   88   O O     . GLU A 1 12  ? 9.870   36.592  52.883 1.00 79.28  ? 14   GLU A O     1 ? 
ATOM   89   C CB    . GLU A 1 12  ? 7.936   36.594  55.648 1.00 89.62  ? 14   GLU A CB    1 ? 
ATOM   90   C CG    . GLU A 1 12  ? 6.837   37.539  56.110 1.00 96.11  ? 14   GLU A CG    1 ? 
ATOM   91   C CD    . GLU A 1 12  ? 6.600   37.547  57.613 1.00 101.15 ? 14   GLU A CD    1 ? 
ATOM   92   O OE1   . GLU A 1 12  ? 7.052   36.601  58.301 1.00 101.63 ? 14   GLU A OE1   1 ? 
ATOM   93   O OE2   . GLU A 1 12  ? 5.938   38.490  58.092 1.00 100.87 ? 14   GLU A OE2   1 ? 
ATOM   94   N N     . GLU A 1 13  ? 9.539   34.534  53.791 1.00 82.55  ? 15   GLU A N     1 ? 
ATOM   95   C CA    . GLU A 1 13  ? 10.822  33.971  53.306 1.00 81.78  ? 15   GLU A CA    1 ? 
ATOM   96   C C     . GLU A 1 13  ? 10.870  34.039  51.777 1.00 80.92  ? 15   GLU A C     1 ? 
ATOM   97   O O     . GLU A 1 13  ? 11.919  34.412  51.230 1.00 82.46  ? 15   GLU A O     1 ? 
ATOM   98   C CB    . GLU A 1 13  ? 10.989  32.524  53.747 1.00 78.72  ? 15   GLU A CB    1 ? 
ATOM   99   C CG    . GLU A 1 13  ? 12.382  32.007  53.477 1.00 78.51  ? 15   GLU A CG    1 ? 
ATOM   100  C CD    . GLU A 1 13  ? 12.459  30.497  53.453 1.00 83.95  ? 15   GLU A CD    1 ? 
ATOM   101  O OE1   . GLU A 1 13  ? 11.371  29.844  53.498 1.00 88.78  ? 15   GLU A OE1   1 ? 
ATOM   102  O OE2   . GLU A 1 13  ? 13.595  29.974  53.389 1.00 78.15  ? 15   GLU A OE2   1 ? 
ATOM   103  N N     . LEU A 1 14  ? 9.778   33.697  51.102 1.00 75.29  ? 16   LEU A N     1 ? 
ATOM   104  C CA    . LEU A 1 14  ? 9.748   33.698  49.617 1.00 76.96  ? 16   LEU A CA    1 ? 
ATOM   105  C C     . LEU A 1 14  ? 9.721   35.125  49.072 1.00 77.15  ? 16   LEU A C     1 ? 
ATOM   106  O O     . LEU A 1 14  ? 9.940   35.280  47.848 1.00 79.75  ? 16   LEU A O     1 ? 
ATOM   107  C CB    . LEU A 1 14  ? 8.527   32.947  49.097 1.00 73.20  ? 16   LEU A CB    1 ? 
ATOM   108  C CG    . LEU A 1 14  ? 8.476   31.457  49.416 1.00 77.73  ? 16   LEU A CG    1 ? 
ATOM   109  C CD1   . LEU A 1 14  ? 7.093   30.904  49.086 1.00 77.13  ? 16   LEU A CD1   1 ? 
ATOM   110  C CD2   . LEU A 1 14  ? 9.560   30.697  48.660 1.00 78.03  ? 16   LEU A CD2   1 ? 
ATOM   111  N N     . CYS A 1 15  ? 9.412   36.122  49.899 1.00 74.05  ? 17   CYS A N     1 ? 
ATOM   112  C CA    . CYS A 1 15  ? 9.417   37.528  49.428 1.00 72.92  ? 17   CYS A CA    1 ? 
ATOM   113  C C     . CYS A 1 15  ? 10.814  38.150  49.594 1.00 75.01  ? 17   CYS A C     1 ? 
ATOM   114  O O     . CYS A 1 15  ? 11.012  39.295  49.155 1.00 70.41  ? 17   CYS A O     1 ? 
ATOM   115  C CB    . CYS A 1 15  ? 8.334   38.339  50.129 1.00 74.88  ? 17   CYS A CB    1 ? 
ATOM   116  S SG    . CYS A 1 15  ? 6.700   38.098  49.374 1.00 76.04  ? 17   CYS A SG    1 ? 
ATOM   117  N N     . THR A 1 16  ? 11.755  37.429  50.194 1.00 71.85  ? 18   THR A N     1 ? 
ATOM   118  C CA    . THR A 1 16  ? 13.089  37.988  50.515 1.00 72.98  ? 18   THR A CA    1 ? 
ATOM   119  C C     . THR A 1 16  ? 13.939  38.038  49.253 1.00 74.47  ? 18   THR A C     1 ? 
ATOM   120  O O     . THR A 1 16  ? 13.689  37.337  48.280 1.00 74.96  ? 18   THR A O     1 ? 
ATOM   121  C CB    . THR A 1 16  ? 13.810  37.180  51.594 1.00 71.74  ? 18   THR A CB    1 ? 
ATOM   122  O OG1   . THR A 1 16  ? 14.059  35.871  51.068 1.00 77.51  ? 18   THR A OG1   1 ? 
ATOM   123  C CG2   . THR A 1 16  ? 13.033  37.166  52.896 1.00 73.98  ? 18   THR A CG2   1 ? 
ATOM   124  N N     . PRO A 1 17  ? 14.969  38.909  49.220 1.00 78.13  ? 19   PRO A N     1 ? 
ATOM   125  C CA    . PRO A 1 17  ? 15.876  38.959  48.082 1.00 75.82  ? 19   PRO A CA    1 ? 
ATOM   126  C C     . PRO A 1 17  ? 16.628  37.640  47.840 1.00 76.78  ? 19   PRO A C     1 ? 
ATOM   127  O O     . PRO A 1 17  ? 17.101  37.004  48.780 1.00 74.61  ? 19   PRO A O     1 ? 
ATOM   128  C CB    . PRO A 1 17  ? 16.877  40.059  48.458 1.00 76.23  ? 19   PRO A CB    1 ? 
ATOM   129  C CG    . PRO A 1 17  ? 16.128  40.924  49.426 1.00 77.33  ? 19   PRO A CG    1 ? 
ATOM   130  C CD    . PRO A 1 17  ? 15.275  39.953  50.214 1.00 79.32  ? 19   PRO A CD    1 ? 
ATOM   131  N N     . GLY A 1 18  ? 16.744  37.282  46.562 1.00 71.08  ? 20   GLY A N     1 ? 
ATOM   132  C CA    . GLY A 1 18  ? 17.212  35.951  46.136 1.00 70.45  ? 20   GLY A CA    1 ? 
ATOM   133  C C     . GLY A 1 18  ? 16.072  35.000  45.799 1.00 73.11  ? 20   GLY A C     1 ? 
ATOM   134  O O     . GLY A 1 18  ? 16.322  34.054  45.036 1.00 75.69  ? 20   GLY A O     1 ? 
ATOM   135  N N     . LEU A 1 19  ? 14.884  35.183  46.382 1.00 73.74  ? 21   LEU A N     1 ? 
ATOM   136  C CA    . LEU A 1 19  ? 13.689  34.355  46.045 1.00 71.29  ? 21   LEU A CA    1 ? 
ATOM   137  C C     . LEU A 1 19  ? 12.686  35.183  45.246 1.00 68.19  ? 21   LEU A C     1 ? 
ATOM   138  O O     . LEU A 1 19  ? 12.339  34.747  44.138 1.00 73.02  ? 21   LEU A O     1 ? 
ATOM   139  C CB    . LEU A 1 19  ? 13.071  33.806  47.328 1.00 66.79  ? 21   LEU A CB    1 ? 
ATOM   140  C CG    . LEU A 1 19  ? 13.992  32.896  48.141 1.00 64.72  ? 21   LEU A CG    1 ? 
ATOM   141  C CD1   . LEU A 1 19  ? 13.273  32.324  49.348 1.00 67.93  ? 21   LEU A CD1   1 ? 
ATOM   142  C CD2   . LEU A 1 19  ? 14.525  31.770  47.285 1.00 66.56  ? 21   LEU A CD2   1 ? 
ATOM   143  N N     . ASP A 1 20  ? 12.358  36.371  45.747 1.00 65.51  ? 22   ASP A N     1 ? 
ATOM   144  C CA    . ASP A 1 20  ? 11.562  37.356  44.975 1.00 69.92  ? 22   ASP A CA    1 ? 
ATOM   145  C C     . ASP A 1 20  ? 10.290  36.763  44.369 1.00 72.11  ? 22   ASP A C     1 ? 
ATOM   146  O O     . ASP A 1 20  ? 10.093  36.918  43.164 1.00 72.83  ? 22   ASP A O     1 ? 
ATOM   147  C CB    . ASP A 1 20  ? 12.481  37.983  43.929 1.00 68.11  ? 22   ASP A CB    1 ? 
ATOM   148  C CG    . ASP A 1 20  ? 13.787  38.486  44.515 1.00 81.86  ? 22   ASP A CG    1 ? 
ATOM   149  O OD1   . ASP A 1 20  ? 13.736  39.405  45.351 1.00 80.60  ? 22   ASP A OD1   1 ? 
ATOM   150  O OD2   . ASP A 1 20  ? 14.842  37.945  44.142 1.00 79.83  ? 22   ASP A OD2   1 ? 
ATOM   151  N N     . GLN A 1 21  ? 9.431   36.181  45.197 1.00 65.74  ? 23   GLN A N     1 ? 
ATOM   152  C CA    . GLN A 1 21  ? 8.150   35.634  44.686 1.00 76.18  ? 23   GLN A CA    1 ? 
ATOM   153  C C     . GLN A 1 21  ? 6.964   36.496  45.157 1.00 76.76  ? 23   GLN A C     1 ? 
ATOM   154  O O     . GLN A 1 21  ? 5.870   35.952  45.345 1.00 77.09  ? 23   GLN A O     1 ? 
ATOM   155  C CB    . GLN A 1 21  ? 7.992   34.172  45.112 1.00 69.86  ? 23   GLN A CB    1 ? 
ATOM   156  C CG    . GLN A 1 21  ? 9.147   33.277  44.683 1.00 70.06  ? 23   GLN A CG    1 ? 
ATOM   157  C CD    . GLN A 1 21  ? 9.192   33.020  43.196 1.00 68.86  ? 23   GLN A CD    1 ? 
ATOM   158  O OE1   . GLN A 1 21  ? 8.193   33.133  42.505 1.00 72.16  ? 23   GLN A OE1   1 ? 
ATOM   159  N NE2   . GLN A 1 21  ? 10.366  32.689  42.684 1.00 70.19  ? 23   GLN A NE2   1 ? 
ATOM   160  N N     . GLY A 1 22  ? 7.153   37.802  45.313 1.00 77.30  ? 24   GLY A N     1 ? 
ATOM   161  C CA    . GLY A 1 22  ? 6.076   38.689  45.781 1.00 75.35  ? 24   GLY A CA    1 ? 
ATOM   162  C C     . GLY A 1 22  ? 4.946   38.811  44.778 1.00 77.29  ? 24   GLY A C     1 ? 
ATOM   163  O O     . GLY A 1 22  ? 3.834   39.125  45.216 1.00 81.66  ? 24   GLY A O     1 ? 
ATOM   164  N N     . HIS A 1 23  ? 5.200   38.576  43.491 1.00 75.58  ? 25   HIS A N     1 ? 
ATOM   165  C CA    . HIS A 1 23  ? 4.154   38.608  42.433 1.00 78.25  ? 25   HIS A CA    1 ? 
ATOM   166  C C     . HIS A 1 23  ? 3.088   37.532  42.693 1.00 78.69  ? 25   HIS A C     1 ? 
ATOM   167  O O     . HIS A 1 23  ? 1.987   37.635  42.146 1.00 81.88  ? 25   HIS A O     1 ? 
ATOM   168  C CB    . HIS A 1 23  ? 4.768   38.418  41.042 1.00 78.26  ? 25   HIS A CB    1 ? 
ATOM   169  C CG    . HIS A 1 23  ? 5.331   37.050  40.827 1.00 86.69  ? 25   HIS A CG    1 ? 
ATOM   170  N ND1   . HIS A 1 23  ? 6.444   36.586  41.523 1.00 83.70  ? 25   HIS A ND1   1 ? 
ATOM   171  C CD2   . HIS A 1 23  ? 4.943   36.046  40.005 1.00 81.85  ? 25   HIS A CD2   1 ? 
ATOM   172  C CE1   . HIS A 1 23  ? 6.718   35.363  41.121 1.00 86.65  ? 25   HIS A CE1   1 ? 
ATOM   173  N NE2   . HIS A 1 23  ? 5.807   35.005  40.189 1.00 81.82  ? 25   HIS A NE2   1 ? 
ATOM   174  N N     . LEU A 1 24  ? 3.418   36.514  43.478 1.00 78.99  ? 26   LEU A N     1 ? 
ATOM   175  C CA    . LEU A 1 24  ? 2.448   35.462  43.860 1.00 81.65  ? 26   LEU A CA    1 ? 
ATOM   176  C C     . LEU A 1 24  ? 1.417   36.017  44.847 1.00 85.89  ? 26   LEU A C     1 ? 
ATOM   177  O O     . LEU A 1 24  ? 0.381   35.355  45.029 1.00 90.48  ? 26   LEU A O     1 ? 
ATOM   178  C CB    . LEU A 1 24  ? 3.206   34.286  44.479 1.00 77.49  ? 26   LEU A CB    1 ? 
ATOM   179  C CG    . LEU A 1 24  ? 3.425   33.073  43.584 1.00 83.04  ? 26   LEU A CG    1 ? 
ATOM   180  C CD1   . LEU A 1 24  ? 3.873   33.464  42.190 1.00 83.97  ? 26   LEU A CD1   1 ? 
ATOM   181  C CD2   . LEU A 1 24  ? 4.433   32.137  44.225 1.00 78.94  ? 26   LEU A CD2   1 ? 
ATOM   182  N N     . PHE A 1 25  ? 1.679   37.161  45.477 1.00 87.49  ? 27   PHE A N     1 ? 
ATOM   183  C CA    . PHE A 1 25  ? 0.844   37.665  46.597 1.00 83.99  ? 27   PHE A CA    1 ? 
ATOM   184  C C     . PHE A 1 25  ? 0.344   39.078  46.329 1.00 77.14  ? 27   PHE A C     1 ? 
ATOM   185  O O     . PHE A 1 25  ? 0.130   39.824  47.280 1.00 77.09  ? 27   PHE A O     1 ? 
ATOM   186  C CB    . PHE A 1 25  ? 1.638   37.647  47.898 1.00 84.02  ? 27   PHE A CB    1 ? 
ATOM   187  C CG    . PHE A 1 25  ? 2.382   36.363  48.128 1.00 87.34  ? 27   PHE A CG    1 ? 
ATOM   188  C CD1   . PHE A 1 25  ? 1.765   35.140  47.932 1.00 86.42  ? 27   PHE A CD1   1 ? 
ATOM   189  C CD2   . PHE A 1 25  ? 3.701   36.383  48.538 1.00 87.25  ? 27   PHE A CD2   1 ? 
ATOM   190  C CE1   . PHE A 1 25  ? 2.453   33.961  48.159 1.00 90.51  ? 27   PHE A CE1   1 ? 
ATOM   191  C CE2   . PHE A 1 25  ? 4.394   35.204  48.742 1.00 91.75  ? 27   PHE A CE2   1 ? 
ATOM   192  C CZ    . PHE A 1 25  ? 3.768   33.995  48.560 1.00 92.06  ? 27   PHE A CZ    1 ? 
ATOM   193  N N     . GLU A 1 26  ? 0.122   39.418  45.069 1.00 82.99  ? 28   GLU A N     1 ? 
ATOM   194  C CA    . GLU A 1 26  ? -0.279  40.800  44.718 1.00 93.12  ? 28   GLU A CA    1 ? 
ATOM   195  C C     . GLU A 1 26  ? -1.680  41.099  45.245 1.00 100.19 ? 28   GLU A C     1 ? 
ATOM   196  O O     . GLU A 1 26  ? -2.604  40.367  44.879 1.00 106.90 ? 28   GLU A O     1 ? 
ATOM   197  C CB    . GLU A 1 26  ? -0.233  40.953  43.202 1.00 96.48  ? 28   GLU A CB    1 ? 
ATOM   198  C CG    . GLU A 1 26  ? 0.019   42.364  42.715 1.00 107.36 ? 28   GLU A CG    1 ? 
ATOM   199  C CD    . GLU A 1 26  ? 0.308   42.419  41.225 1.00 116.78 ? 28   GLU A CD    1 ? 
ATOM   200  O OE1   . GLU A 1 26  ? 1.413   42.852  40.858 1.00 115.71 ? 28   GLU A OE1   1 ? 
ATOM   201  O OE2   . GLU A 1 26  ? -0.568  42.014  40.438 1.00 114.68 ? 28   GLU A OE2   1 ? 
ATOM   202  N N     . GLY A 1 27  ? -1.819  42.126  46.073 1.00 103.04 ? 29   GLY A N     1 ? 
ATOM   203  C CA    . GLY A 1 27  ? -3.131  42.577  46.582 1.00 98.47  ? 29   GLY A CA    1 ? 
ATOM   204  C C     . GLY A 1 27  ? -3.623  41.727  47.734 1.00 97.08  ? 29   GLY A C     1 ? 
ATOM   205  O O     . GLY A 1 27  ? -4.801  41.865  48.106 1.00 106.53 ? 29   GLY A O     1 ? 
ATOM   206  N N     . TRP A 1 28  ? -2.766  40.884  48.289 1.00 82.87  ? 30   TRP A N     1 ? 
ATOM   207  C CA    . TRP A 1 28  ? -3.215  39.996  49.385 1.00 88.93  ? 30   TRP A CA    1 ? 
ATOM   208  C C     . TRP A 1 28  ? -3.187  40.759  50.710 1.00 94.86  ? 30   TRP A C     1 ? 
ATOM   209  O O     . TRP A 1 28  ? -2.412  41.717  50.821 1.00 92.80  ? 30   TRP A O     1 ? 
ATOM   210  C CB    . TRP A 1 28  ? -2.339  38.743  49.470 1.00 90.71  ? 30   TRP A CB    1 ? 
ATOM   211  C CG    . TRP A 1 28  ? -2.503  37.725  48.387 1.00 79.21  ? 30   TRP A CG    1 ? 
ATOM   212  C CD1   . TRP A 1 28  ? -3.053  37.896  47.152 1.00 82.70  ? 30   TRP A CD1   1 ? 
ATOM   213  C CD2   . TRP A 1 28  ? -2.121  36.343  48.469 1.00 71.83  ? 30   TRP A CD2   1 ? 
ATOM   214  N NE1   . TRP A 1 28  ? -3.025  36.717  46.459 1.00 77.66  ? 30   TRP A NE1   1 ? 
ATOM   215  C CE2   . TRP A 1 28  ? -2.457  35.747  47.238 1.00 75.64  ? 30   TRP A CE2   1 ? 
ATOM   216  C CE3   . TRP A 1 28  ? -1.526  35.556  49.459 1.00 70.85  ? 30   TRP A CE3   1 ? 
ATOM   217  C CZ2   . TRP A 1 28  ? -2.218  34.402  46.973 1.00 74.48  ? 30   TRP A CZ2   1 ? 
ATOM   218  C CZ3   . TRP A 1 28  ? -1.290  34.227  49.197 1.00 69.62  ? 30   TRP A CZ3   1 ? 
ATOM   219  C CH2   . TRP A 1 28  ? -1.629  33.660  47.970 1.00 71.84  ? 30   TRP A CH2   1 ? 
ATOM   220  N N     . PRO A 1 29  ? -4.007  40.390  51.713 1.00 100.26 ? 31   PRO A N     1 ? 
ATOM   221  C CA    . PRO A 1 29  ? -3.945  40.991  53.038 1.00 101.04 ? 31   PRO A CA    1 ? 
ATOM   222  C C     . PRO A 1 29  ? -2.625  40.679  53.744 1.00 104.06 ? 31   PRO A C     1 ? 
ATOM   223  O O     . PRO A 1 29  ? -1.992  39.685  53.436 1.00 103.70 ? 31   PRO A O     1 ? 
ATOM   224  C CB    . PRO A 1 29  ? -5.116  40.350  53.788 1.00 104.81 ? 31   PRO A CB    1 ? 
ATOM   225  C CG    . PRO A 1 29  ? -5.335  39.041  53.069 1.00 105.50 ? 31   PRO A CG    1 ? 
ATOM   226  C CD    . PRO A 1 29  ? -5.050  39.355  51.614 1.00 107.36 ? 31   PRO A CD    1 ? 
ATOM   227  N N     . GLU A 1 30  ? -2.269  41.536  54.692 1.00 103.48 ? 32   GLU A N     1 ? 
ATOM   228  C CA    . GLU A 1 30  ? -0.961  41.462  55.375 1.00 107.18 ? 32   GLU A CA    1 ? 
ATOM   229  C C     . GLU A 1 30  ? -0.867  40.145  56.145 1.00 110.10 ? 32   GLU A C     1 ? 
ATOM   230  O O     . GLU A 1 30  ? 0.214   39.516  56.099 1.00 116.64 ? 32   GLU A O     1 ? 
ATOM   231  C CB    . GLU A 1 30  ? -0.772  42.665  56.295 1.00 113.49 ? 32   GLU A CB    1 ? 
ATOM   232  C CG    . GLU A 1 30  ? 0.487   42.572  57.144 1.00 117.35 ? 32   GLU A CG    1 ? 
ATOM   233  C CD    . GLU A 1 30  ? 1.331   43.836  57.123 1.00 122.01 ? 32   GLU A CD    1 ? 
ATOM   234  O OE1   . GLU A 1 30  ? 1.459   44.442  56.031 1.00 119.93 ? 32   GLU A OE1   1 ? 
ATOM   235  O OE2   . GLU A 1 30  ? 1.853   44.215  58.194 1.00 122.68 ? 32   GLU A OE2   1 ? 
ATOM   236  N N     . THR A 1 31  ? -1.935  39.750  56.834 1.00 110.98 ? 33   THR A N     1 ? 
ATOM   237  C CA    . THR A 1 31  ? -1.888  38.574  57.739 1.00 117.46 ? 33   THR A CA    1 ? 
ATOM   238  C C     . THR A 1 31  ? -2.526  37.375  57.041 1.00 110.90 ? 33   THR A C     1 ? 
ATOM   239  O O     . THR A 1 31  ? -3.382  37.563  56.135 1.00 111.34 ? 33   THR A O     1 ? 
ATOM   240  C CB    . THR A 1 31  ? -2.548  38.864  59.090 1.00 118.81 ? 33   THR A CB    1 ? 
ATOM   241  O OG1   . THR A 1 31  ? -2.364  40.252  59.383 1.00 128.53 ? 33   THR A OG1   1 ? 
ATOM   242  C CG2   . THR A 1 31  ? -1.983  37.990  60.190 1.00 117.33 ? 33   THR A CG2   1 ? 
ATOM   243  N N     . VAL A 1 32  ? -2.089  36.192  57.448 1.00 106.09 ? 34   VAL A N     1 ? 
ATOM   244  C CA    . VAL A 1 32  ? -2.622  34.903  56.927 1.00 119.64 ? 34   VAL A CA    1 ? 
ATOM   245  C C     . VAL A 1 32  ? -4.037  34.673  57.464 1.00 110.89 ? 34   VAL A C     1 ? 
ATOM   246  O O     . VAL A 1 32  ? -4.887  34.183  56.702 1.00 105.95 ? 34   VAL A O     1 ? 
ATOM   247  C CB    . VAL A 1 32  ? -1.682  33.741  57.283 1.00 124.58 ? 34   VAL A CB    1 ? 
ATOM   248  C CG1   . VAL A 1 32  ? -0.513  33.696  56.313 1.00 127.13 ? 34   VAL A CG1   1 ? 
ATOM   249  C CG2   . VAL A 1 32  ? -1.196  33.825  58.726 1.00 126.76 ? 34   VAL A CG2   1 ? 
ATOM   250  N N     . ASP A 1 33  ? -4.290  35.031  58.720 1.00 111.31 ? 35   ASP A N     1 ? 
ATOM   251  C CA    . ASP A 1 33  ? -5.621  34.824  59.344 1.00 114.14 ? 35   ASP A CA    1 ? 
ATOM   252  C C     . ASP A 1 33  ? -6.679  35.647  58.604 1.00 113.40 ? 35   ASP A C     1 ? 
ATOM   253  O O     . ASP A 1 33  ? -7.866  35.277  58.697 1.00 112.93 ? 35   ASP A O     1 ? 
ATOM   254  C CB    . ASP A 1 33  ? -5.570  35.127  60.842 1.00 120.51 ? 35   ASP A CB    1 ? 
ATOM   255  C CG    . ASP A 1 33  ? -4.749  34.106  61.625 1.00 123.55 ? 35   ASP A CG    1 ? 
ATOM   256  O OD1   . ASP A 1 33  ? -4.929  32.883  61.378 1.00 118.38 ? 35   ASP A OD1   1 ? 
ATOM   257  O OD2   . ASP A 1 33  ? -3.922  34.530  62.467 1.00 115.09 ? 35   ASP A OD2   1 ? 
ATOM   258  N N     . GLU A 1 34  ? -6.263  36.691  57.880 1.00 117.68 ? 36   GLU A N     1 ? 
ATOM   259  C CA    . GLU A 1 34  ? -7.206  37.567  57.135 1.00 114.96 ? 36   GLU A CA    1 ? 
ATOM   260  C C     . GLU A 1 34  ? -7.319  37.129  55.672 1.00 111.06 ? 36   GLU A C     1 ? 
ATOM   261  O O     . GLU A 1 34  ? -8.004  37.832  54.917 1.00 106.32 ? 36   GLU A O     1 ? 
ATOM   262  C CB    . GLU A 1 34  ? -6.709  39.011  57.160 1.00 119.62 ? 36   GLU A CB    1 ? 
ATOM   263  C CG    . GLU A 1 34  ? -5.937  39.363  58.415 1.00 124.70 ? 36   GLU A CG    1 ? 
ATOM   264  C CD    . GLU A 1 34  ? -5.399  40.782  58.435 1.00 127.31 ? 36   GLU A CD    1 ? 
ATOM   265  O OE1   . GLU A 1 34  ? -5.726  41.519  59.380 1.00 123.23 ? 36   GLU A OE1   1 ? 
ATOM   266  O OE2   . GLU A 1 34  ? -4.659  41.146  57.502 1.00 126.97 ? 36   GLU A OE2   1 ? 
ATOM   267  N N     . CYS A 1 35  ? -6.665  36.027  55.285 1.00 109.53 ? 37   CYS A N     1 ? 
ATOM   268  C CA    . CYS A 1 35  ? -6.669  35.586  53.867 1.00 119.65 ? 37   CYS A CA    1 ? 
ATOM   269  C C     . CYS A 1 35  ? -7.704  34.482  53.679 1.00 112.54 ? 37   CYS A C     1 ? 
ATOM   270  O O     . CYS A 1 35  ? -8.072  33.816  54.679 1.00 114.63 ? 37   CYS A O     1 ? 
ATOM   271  C CB    . CYS A 1 35  ? -5.275  35.191  53.393 0.30 129.98 ? 37   CYS A CB    1 ? 
ATOM   272  S SG    . CYS A 1 35  ? -4.780  33.493  53.772 0.30 144.80 ? 37   CYS A SG    1 ? 
ATOM   273  N N     . ASN A 1 36  ? -8.164  34.335  52.438 1.00 101.15 ? 38   ASN A N     1 ? 
ATOM   274  C CA    . ASN A 1 36  ? -9.311  33.473  52.073 1.00 102.70 ? 38   ASN A CA    1 ? 
ATOM   275  C C     . ASN A 1 36  ? -8.816  32.082  51.663 1.00 106.06 ? 38   ASN A C     1 ? 
ATOM   276  O O     . ASN A 1 36  ? -7.612  31.794  51.824 1.00 95.92  ? 38   ASN A O     1 ? 
ATOM   277  C CB    . ASN A 1 36  ? -10.142 34.118  50.969 1.00 99.48  ? 38   ASN A CB    1 ? 
ATOM   278  C CG    . ASN A 1 36  ? -9.365  34.312  49.687 1.00 98.70  ? 38   ASN A CG    1 ? 
ATOM   279  O OD1   . ASN A 1 36  ? -8.596  33.441  49.275 1.00 106.33 ? 38   ASN A OD1   1 ? 
ATOM   280  N ND2   . ASN A 1 36  ? -9.583  35.440  49.034 1.00 94.67  ? 38   ASN A ND2   1 ? 
ATOM   281  N N     . GLU A 1 37  ? -9.705  31.230  51.140 1.00 111.62 ? 39   GLU A N     1 ? 
ATOM   282  C CA    . GLU A 1 37  ? -9.359  29.802  50.854 1.00 113.90 ? 39   GLU A CA    1 ? 
ATOM   283  C C     . GLU A 1 37  ? -8.349  29.630  49.709 1.00 105.76 ? 39   GLU A C     1 ? 
ATOM   284  O O     . GLU A 1 37  ? -7.397  28.851  49.895 1.00 99.31  ? 39   GLU A O     1 ? 
ATOM   285  C CB    . GLU A 1 37  ? -10.641 29.014  50.554 1.00 110.60 ? 39   GLU A CB    1 ? 
ATOM   286  C CG    . GLU A 1 37  ? -11.684 29.101  51.653 1.00 109.62 ? 39   GLU A CG    1 ? 
ATOM   287  C CD    . GLU A 1 37  ? -13.047 28.552  51.272 1.00 113.90 ? 39   GLU A CD    1 ? 
ATOM   288  O OE1   . GLU A 1 37  ? -13.291 28.369  50.067 1.00 103.33 ? 39   GLU A OE1   1 ? 
ATOM   289  O OE2   . GLU A 1 37  ? -13.857 28.308  52.182 1.00 106.79 ? 39   GLU A OE2   1 ? 
ATOM   290  N N     . ARG A 1 38  ? -8.566  30.276  48.561 1.00 99.62  ? 40   ARG A N     1 ? 
ATOM   291  C CA    . ARG A 1 38  ? -7.664  30.068  47.392 1.00 108.61 ? 40   ARG A CA    1 ? 
ATOM   292  C C     . ARG A 1 38  ? -6.232  30.463  47.775 1.00 108.26 ? 40   ARG A C     1 ? 
ATOM   293  O O     . ARG A 1 38  ? -5.295  29.790  47.320 1.00 95.38  ? 40   ARG A O     1 ? 
ATOM   294  C CB    . ARG A 1 38  ? -8.154  30.869  46.183 1.00 110.40 ? 40   ARG A CB    1 ? 
ATOM   295  C CG    . ARG A 1 38  ? -9.303  30.222  45.426 1.00 118.51 ? 40   ARG A CG    1 ? 
ATOM   296  C CD    . ARG A 1 38  ? -8.871  28.878  44.882 1.00 124.19 ? 40   ARG A CD    1 ? 
ATOM   297  N NE    . ARG A 1 38  ? -9.879  28.294  44.015 1.00 126.41 ? 40   ARG A NE    1 ? 
ATOM   298  C CZ    . ARG A 1 38  ? -10.887 27.548  44.441 1.00 125.52 ? 40   ARG A CZ    1 ? 
ATOM   299  N NH1   . ARG A 1 38  ? -11.027 27.297  45.731 1.00 120.41 ? 40   ARG A NH1   1 ? 
ATOM   300  N NH2   . ARG A 1 38  ? -11.753 27.057  43.575 1.00 119.35 ? 40   ARG A NH2   1 ? 
ATOM   301  N N     . GLN A 1 39  ? -6.081  31.516  48.578 1.00 103.27 ? 41   GLN A N     1 ? 
ATOM   302  C CA    . GLN A 1 39  ? -4.745  31.986  49.026 1.00 96.24  ? 41   GLN A CA    1 ? 
ATOM   303  C C     . GLN A 1 39  ? -4.163  30.953  49.993 1.00 93.59  ? 41   GLN A C     1 ? 
ATOM   304  O O     . GLN A 1 39  ? -3.014  30.555  49.790 1.00 105.01 ? 41   GLN A O     1 ? 
ATOM   305  C CB    . GLN A 1 39  ? -4.917  33.386  49.617 1.00 91.25  ? 41   GLN A CB    1 ? 
ATOM   306  C CG    . GLN A 1 39  ? -5.463  34.383  48.605 1.00 88.63  ? 41   GLN A CG    1 ? 
ATOM   307  C CD    . GLN A 1 39  ? -5.740  35.748  49.185 1.00 90.26  ? 41   GLN A CD    1 ? 
ATOM   308  O OE1   . GLN A 1 39  ? -5.745  35.939  50.396 1.00 97.30  ? 41   GLN A OE1   1 ? 
ATOM   309  N NE2   . GLN A 1 39  ? -5.986  36.712  48.314 1.00 85.89  ? 41   GLN A NE2   1 ? 
ATOM   310  N N     . ILE A 1 40  ? -4.932  30.530  50.990 1.00 84.18  ? 42   ILE A N     1 ? 
ATOM   311  C CA    . ILE A 1 40  ? -4.490  29.463  51.933 1.00 87.98  ? 42   ILE A CA    1 ? 
ATOM   312  C C     . ILE A 1 40  ? -4.078  28.227  51.139 1.00 87.41  ? 42   ILE A C     1 ? 
ATOM   313  O O     . ILE A 1 40  ? -3.097  27.579  51.545 1.00 96.42  ? 42   ILE A O     1 ? 
ATOM   314  C CB    . ILE A 1 40  ? -5.578  29.116  52.960 1.00 101.86 ? 42   ILE A CB    1 ? 
ATOM   315  C CG1   . ILE A 1 40  ? -5.724  30.230  53.999 1.00 107.75 ? 42   ILE A CG1   1 ? 
ATOM   316  C CG2   . ILE A 1 40  ? -5.294  27.766  53.609 1.00 104.17 ? 42   ILE A CG2   1 ? 
ATOM   317  C CD1   . ILE A 1 40  ? -6.339  29.785  55.318 1.00 110.81 ? 42   ILE A CD1   1 ? 
ATOM   318  N N     . ALA A 1 41  ? -4.818  27.882  50.088 1.00 86.51  ? 43   ALA A N     1 ? 
ATOM   319  C CA    . ALA A 1 41  ? -4.524  26.672  49.286 1.00 91.63  ? 43   ALA A CA    1 ? 
ATOM   320  C C     . ALA A 1 41  ? -3.181  26.844  48.567 1.00 89.86  ? 43   ALA A C     1 ? 
ATOM   321  O O     . ALA A 1 41  ? -2.390  25.877  48.542 1.00 95.57  ? 43   ALA A O     1 ? 
ATOM   322  C CB    . ALA A 1 41  ? -5.642  26.393  48.314 1.00 87.35  ? 43   ALA A CB    1 ? 
ATOM   323  N N     . LEU A 1 42  ? -2.928  28.023  48.002 1.00 88.91  ? 44   LEU A N     1 ? 
ATOM   324  C CA    . LEU A 1 42  ? -1.651  28.300  47.290 1.00 89.85  ? 44   LEU A CA    1 ? 
ATOM   325  C C     . LEU A 1 42  ? -0.466  28.290  48.267 1.00 83.81  ? 44   LEU A C     1 ? 
ATOM   326  O O     . LEU A 1 42  ? 0.588   27.718  47.919 1.00 83.38  ? 44   LEU A O     1 ? 
ATOM   327  C CB    . LEU A 1 42  ? -1.742  29.650  46.588 1.00 86.77  ? 44   LEU A CB    1 ? 
ATOM   328  C CG    . LEU A 1 42  ? -0.686  29.878  45.512 1.00 88.97  ? 44   LEU A CG    1 ? 
ATOM   329  C CD1   . LEU A 1 42  ? -1.300  30.578  44.319 1.00 87.00  ? 44   LEU A CD1   1 ? 
ATOM   330  C CD2   . LEU A 1 42  ? 0.489   30.679  46.054 1.00 93.33  ? 44   LEU A CD2   1 ? 
ATOM   331  N N     . LEU A 1 43  ? -0.613  28.900  49.439 1.00 78.25  ? 45   LEU A N     1 ? 
ATOM   332  C CA    . LEU A 1 43  ? 0.455   28.840  50.463 1.00 80.70  ? 45   LEU A CA    1 ? 
ATOM   333  C C     . LEU A 1 43  ? 0.663   27.394  50.893 1.00 78.09  ? 45   LEU A C     1 ? 
ATOM   334  O O     . LEU A 1 43  ? 1.832   27.012  51.075 1.00 77.97  ? 45   LEU A O     1 ? 
ATOM   335  C CB    . LEU A 1 43  ? 0.105   29.738  51.651 1.00 90.36  ? 45   LEU A CB    1 ? 
ATOM   336  C CG    . LEU A 1 43  ? 0.796   31.100  51.667 1.00 90.10  ? 45   LEU A CG    1 ? 
ATOM   337  C CD1   . LEU A 1 43  ? 0.741   31.746  50.296 1.00 96.29  ? 45   LEU A CD1   1 ? 
ATOM   338  C CD2   . LEU A 1 43  ? 0.163   32.014  52.702 1.00 95.57  ? 45   LEU A CD2   1 ? 
ATOM   339  N N     . THR A 1 44  ? -0.413  26.620  51.031 1.00 83.84  ? 46   THR A N     1 ? 
ATOM   340  C CA    . THR A 1 44  ? -0.293  25.213  51.482 1.00 92.91  ? 46   THR A CA    1 ? 
ATOM   341  C C     . THR A 1 44  ? 0.438   24.397  50.418 1.00 87.37  ? 46   THR A C     1 ? 
ATOM   342  O O     . THR A 1 44  ? 1.289   23.561  50.790 1.00 82.50  ? 46   THR A O     1 ? 
ATOM   343  C CB    . THR A 1 44  ? -1.657  24.609  51.810 1.00 99.88  ? 46   THR A CB    1 ? 
ATOM   344  O OG1   . THR A 1 44  ? -2.367  25.566  52.601 1.00 99.40  ? 46   THR A OG1   1 ? 
ATOM   345  C CG2   . THR A 1 44  ? -1.509  23.307  52.566 1.00 95.51  ? 46   THR A CG2   1 ? 
ATOM   346  N N     . ASP A 1 45  ? 0.121   24.639  49.150 1.00 87.58  ? 47   ASP A N     1 ? 
ATOM   347  C CA    . ASP A 1 45  ? 0.826   23.989  48.016 1.00 86.80  ? 47   ASP A CA    1 ? 
ATOM   348  C C     . ASP A 1 45  ? 2.324   24.299  48.098 1.00 86.47  ? 47   ASP A C     1 ? 
ATOM   349  O O     . ASP A 1 45  ? 3.138   23.367  47.865 1.00 84.25  ? 47   ASP A O     1 ? 
ATOM   350  C CB    . ASP A 1 45  ? 0.257   24.473  46.683 1.00 87.53  ? 47   ASP A CB    1 ? 
ATOM   351  C CG    . ASP A 1 45  ? 0.525   23.526  45.521 1.00 94.18  ? 47   ASP A CG    1 ? 
ATOM   352  O OD1   . ASP A 1 45  ? 0.980   22.367  45.800 1.00 104.47 ? 47   ASP A OD1   1 ? 
ATOM   353  O OD2   . ASP A 1 45  ? 0.302   23.965  44.338 1.00 75.26  ? 47   ASP A OD2   1 ? 
ATOM   354  N N     . LEU A 1 46  ? 2.669   25.558  48.405 1.00 81.93  ? 48   LEU A N     1 ? 
ATOM   355  C CA    . LEU A 1 46  ? 4.087   25.972  48.518 1.00 74.92  ? 48   LEU A CA    1 ? 
ATOM   356  C C     . LEU A 1 46  ? 4.701   25.252  49.710 1.00 74.06  ? 48   LEU A C     1 ? 
ATOM   357  O O     . LEU A 1 46  ? 5.822   24.708  49.556 1.00 80.10  ? 48   LEU A O     1 ? 
ATOM   358  C CB    . LEU A 1 46  ? 4.189   27.491  48.660 1.00 75.68  ? 48   LEU A CB    1 ? 
ATOM   359  C CG    . LEU A 1 46  ? 3.967   28.296  47.379 1.00 79.27  ? 48   LEU A CG    1 ? 
ATOM   360  C CD1   . LEU A 1 46  ? 3.777   29.763  47.705 1.00 82.81  ? 48   LEU A CD1   1 ? 
ATOM   361  C CD2   . LEU A 1 46  ? 5.114   28.134  46.410 1.00 81.88  ? 48   LEU A CD2   1 ? 
ATOM   362  N N     . TYR A 1 47  ? 3.991   25.213  50.837 1.00 69.12  ? 49   TYR A N     1 ? 
ATOM   363  C CA    . TYR A 1 47  ? 4.560   24.670  52.093 1.00 75.61  ? 49   TYR A CA    1 ? 
ATOM   364  C C     . TYR A 1 47  ? 4.821   23.169  51.944 1.00 81.96  ? 49   TYR A C     1 ? 
ATOM   365  O O     . TYR A 1 47  ? 5.927   22.725  52.308 1.00 82.27  ? 49   TYR A O     1 ? 
ATOM   366  C CB    . TYR A 1 47  ? 3.647   24.964  53.280 1.00 83.75  ? 49   TYR A CB    1 ? 
ATOM   367  C CG    . TYR A 1 47  ? 4.291   24.666  54.610 1.00 85.65  ? 49   TYR A CG    1 ? 
ATOM   368  C CD1   . TYR A 1 47  ? 4.230   23.398  55.171 1.00 89.19  ? 49   TYR A CD1   1 ? 
ATOM   369  C CD2   . TYR A 1 47  ? 4.998   25.643  55.292 1.00 85.29  ? 49   TYR A CD2   1 ? 
ATOM   370  C CE1   . TYR A 1 47  ? 4.824   23.118  56.391 1.00 90.68  ? 49   TYR A CE1   1 ? 
ATOM   371  C CE2   . TYR A 1 47  ? 5.606   25.380  56.506 1.00 84.87  ? 49   TYR A CE2   1 ? 
ATOM   372  C CZ    . TYR A 1 47  ? 5.518   24.115  57.058 1.00 91.50  ? 49   TYR A CZ    1 ? 
ATOM   373  O OH    . TYR A 1 47  ? 6.128   23.876  58.255 1.00 91.05  ? 49   TYR A OH    1 ? 
ATOM   374  N N     . MET A 1 48  ? 3.853   22.422  51.410 1.00 83.59  ? 50   MET A N     1 ? 
ATOM   375  C CA    . MET A 1 48  ? 3.937   20.939  51.384 1.00 89.18  ? 50   MET A CA    1 ? 
ATOM   376  C C     . MET A 1 48  ? 4.705   20.468  50.152 1.00 93.13  ? 50   MET A C     1 ? 
ATOM   377  O O     . MET A 1 48  ? 4.896   19.240  50.021 1.00 98.83  ? 50   MET A O     1 ? 
ATOM   378  C CB    . MET A 1 48  ? 2.550   20.290  51.380 1.00 101.05 ? 50   MET A CB    1 ? 
ATOM   379  C CG    . MET A 1 48  ? 1.552   20.950  52.330 1.00 96.45  ? 50   MET A CG    1 ? 
ATOM   380  S SD    . MET A 1 48  ? 1.667   20.269  53.996 1.00 98.19  ? 50   MET A SD    1 ? 
ATOM   381  C CE    . MET A 1 48  ? 1.478   18.522  53.644 1.00 95.69  ? 50   MET A CE    1 ? 
ATOM   382  N N     . PHE A 1 49  ? 5.158   21.378  49.290 1.00 86.91  ? 51   PHE A N     1 ? 
ATOM   383  C CA    . PHE A 1 49  ? 6.114   21.004  48.222 1.00 78.03  ? 51   PHE A CA    1 ? 
ATOM   384  C C     . PHE A 1 49  ? 7.378   20.422  48.863 1.00 77.59  ? 51   PHE A C     1 ? 
ATOM   385  O O     . PHE A 1 49  ? 8.121   19.643  48.238 1.00 82.41  ? 51   PHE A O     1 ? 
ATOM   386  C CB    . PHE A 1 49  ? 6.459   22.197  47.345 1.00 77.08  ? 51   PHE A CB    1 ? 
ATOM   387  C CG    . PHE A 1 49  ? 7.313   21.812  46.171 1.00 83.34  ? 51   PHE A CG    1 ? 
ATOM   388  C CD1   . PHE A 1 49  ? 6.829   20.954  45.190 1.00 77.91  ? 51   PHE A CD1   1 ? 
ATOM   389  C CD2   . PHE A 1 49  ? 8.614   22.279  46.067 1.00 79.99  ? 51   PHE A CD2   1 ? 
ATOM   390  C CE1   . PHE A 1 49  ? 7.621   20.603  44.107 1.00 80.53  ? 51   PHE A CE1   1 ? 
ATOM   391  C CE2   . PHE A 1 49  ? 9.407   21.917  44.991 1.00 81.72  ? 51   PHE A CE2   1 ? 
ATOM   392  C CZ    . PHE A 1 49  ? 8.909   21.082  44.011 1.00 81.39  ? 51   PHE A CZ    1 ? 
ATOM   393  N N     . SER A 1 50  ? 7.645   20.793  50.103 1.00 74.89  ? 52   SER A N     1 ? 
ATOM   394  C CA    . SER A 1 50  ? 8.862   20.325  50.804 1.00 72.56  ? 52   SER A CA    1 ? 
ATOM   395  C C     . SER A 1 50  ? 8.810   18.813  51.042 1.00 79.47  ? 52   SER A C     1 ? 
ATOM   396  O O     . SER A 1 50  ? 9.881   18.197  51.230 1.00 70.05  ? 52   SER A O     1 ? 
ATOM   397  C CB    . SER A 1 50  ? 9.058   21.070  52.089 1.00 75.16  ? 52   SER A CB    1 ? 
ATOM   398  O OG    . SER A 1 50  ? 10.008  20.398  52.890 1.00 81.52  ? 52   SER A OG    1 ? 
ATOM   399  N N     . ASN A 1 51  ? 7.608   18.239  51.062 1.00 88.54  ? 53   ASN A N     1 ? 
ATOM   400  C CA    . ASN A 1 51  ? 7.422   16.788  51.316 1.00 82.00  ? 53   ASN A CA    1 ? 
ATOM   401  C C     . ASN A 1 51  ? 8.004   15.981  50.158 1.00 82.28  ? 53   ASN A C     1 ? 
ATOM   402  O O     . ASN A 1 51  ? 8.545   14.902  50.436 1.00 91.05  ? 53   ASN A O     1 ? 
ATOM   403  C CB    . ASN A 1 51  ? 5.950   16.444  51.549 1.00 91.60  ? 53   ASN A CB    1 ? 
ATOM   404  C CG    . ASN A 1 51  ? 5.635   16.119  52.998 1.00 103.79 ? 53   ASN A CG    1 ? 
ATOM   405  O OD1   . ASN A 1 51  ? 6.177   16.725  53.932 1.00 102.57 ? 53   ASN A OD1   1 ? 
ATOM   406  N ND2   . ASN A 1 51  ? 4.759   15.145  53.199 1.00 105.11 ? 53   ASN A ND2   1 ? 
ATOM   407  N N     . MET A 1 52  ? 7.941   16.504  48.930 1.00 79.89  ? 54   MET A N     1 ? 
ATOM   408  C CA    . MET A 1 52  ? 8.364   15.753  47.723 1.00 76.24  ? 54   MET A CA    1 ? 
ATOM   409  C C     . MET A 1 52  ? 9.653   16.310  47.122 1.00 80.68  ? 54   MET A C     1 ? 
ATOM   410  O O     . MET A 1 52  ? 10.130  15.686  46.174 1.00 81.88  ? 54   MET A O     1 ? 
ATOM   411  C CB    . MET A 1 52  ? 7.264   15.772  46.663 1.00 75.72  ? 54   MET A CB    1 ? 
ATOM   412  C CG    . MET A 1 52  ? 6.848   17.156  46.211 1.00 82.76  ? 54   MET A CG    1 ? 
ATOM   413  S SD    . MET A 1 52  ? 6.225   17.205  44.490 1.00 88.92  ? 54   MET A SD    1 ? 
ATOM   414  C CE    . MET A 1 52  ? 7.622   16.465  43.644 1.00 93.94  ? 54   MET A CE    1 ? 
ATOM   415  N N     . TYR A 1 53  ? 10.193  17.422  47.630 1.00 79.48  ? 55   TYR A N     1 ? 
ATOM   416  C CA    . TYR A 1 53  ? 11.450  18.014  47.092 1.00 78.49  ? 55   TYR A CA    1 ? 
ATOM   417  C C     . TYR A 1 53  ? 12.402  18.388  48.219 1.00 72.20  ? 55   TYR A C     1 ? 
ATOM   418  O O     . TYR A 1 53  ? 11.991  18.919  49.245 1.00 77.52  ? 55   TYR A O     1 ? 
ATOM   419  C CB    . TYR A 1 53  ? 11.166  19.247  46.233 1.00 75.91  ? 55   TYR A CB    1 ? 
ATOM   420  C CG    . TYR A 1 53  ? 12.319  19.644  45.351 1.00 70.92  ? 55   TYR A CG    1 ? 
ATOM   421  C CD1   . TYR A 1 53  ? 13.309  20.498  45.815 1.00 74.39  ? 55   TYR A CD1   1 ? 
ATOM   422  C CD2   . TYR A 1 53  ? 12.448  19.134  44.066 1.00 72.46  ? 55   TYR A CD2   1 ? 
ATOM   423  C CE1   . TYR A 1 53  ? 14.381  20.867  45.017 1.00 69.23  ? 55   TYR A CE1   1 ? 
ATOM   424  C CE2   . TYR A 1 53  ? 13.521  19.488  43.256 1.00 75.71  ? 55   TYR A CE2   1 ? 
ATOM   425  C CZ    . TYR A 1 53  ? 14.479  20.369  43.733 1.00 68.02  ? 55   TYR A CZ    1 ? 
ATOM   426  O OH    . TYR A 1 53  ? 15.526  20.720  42.948 1.00 69.64  ? 55   TYR A OH    1 ? 
ATOM   427  N N     . PRO A 1 54  ? 13.710  18.092  48.074 1.00 71.49  ? 56   PRO A N     1 ? 
ATOM   428  C CA    . PRO A 1 54  ? 14.661  18.364  49.147 1.00 69.67  ? 56   PRO A CA    1 ? 
ATOM   429  C C     . PRO A 1 54  ? 14.840  19.877  49.332 1.00 74.70  ? 56   PRO A C     1 ? 
ATOM   430  O O     . PRO A 1 54  ? 15.286  20.552  48.400 1.00 70.03  ? 56   PRO A O     1 ? 
ATOM   431  C CB    . PRO A 1 54  ? 15.980  17.718  48.696 1.00 63.36  ? 56   PRO A CB    1 ? 
ATOM   432  C CG    . PRO A 1 54  ? 15.621  16.845  47.517 1.00 64.21  ? 56   PRO A CG    1 ? 
ATOM   433  C CD    . PRO A 1 54  ? 14.336  17.394  46.934 1.00 68.27  ? 56   PRO A CD    1 ? 
ATOM   434  N N     . GLY A 1 55  ? 14.456  20.371  50.510 1.00 68.14  ? 57   GLY A N     1 ? 
ATOM   435  C CA    . GLY A 1 55  ? 14.575  21.793  50.855 1.00 65.39  ? 57   GLY A CA    1 ? 
ATOM   436  C C     . GLY A 1 55  ? 13.335  22.593  50.498 1.00 69.18  ? 57   GLY A C     1 ? 
ATOM   437  O O     . GLY A 1 55  ? 13.279  23.775  50.859 1.00 79.84  ? 57   GLY A O     1 ? 
ATOM   438  N N     . GLY A 1 56  ? 12.351  22.003  49.826 1.00 64.75  ? 58   GLY A N     1 ? 
ATOM   439  C CA    . GLY A 1 56  ? 11.099  22.722  49.538 1.00 65.84  ? 58   GLY A CA    1 ? 
ATOM   440  C C     . GLY A 1 56  ? 11.249  23.716  48.403 1.00 68.56  ? 58   GLY A C     1 ? 
ATOM   441  O O     . GLY A 1 56  ? 12.229  23.627  47.630 1.00 67.29  ? 58   GLY A O     1 ? 
ATOM   442  N N     . VAL A 1 57  ? 10.286  24.626  48.312 1.00 65.57  ? 59   VAL A N     1 ? 
ATOM   443  C CA    . VAL A 1 57  ? 10.151  25.560  47.167 1.00 65.30  ? 59   VAL A CA    1 ? 
ATOM   444  C C     . VAL A 1 57  ? 11.325  26.546  47.162 1.00 68.51  ? 59   VAL A C     1 ? 
ATOM   445  O O     . VAL A 1 57  ? 11.791  26.914  46.075 1.00 68.29  ? 59   VAL A O     1 ? 
ATOM   446  C CB    . VAL A 1 57  ? 8.784   26.265  47.206 1.00 65.86  ? 59   VAL A CB    1 ? 
ATOM   447  C CG1   . VAL A 1 57  ? 8.585   27.043  48.498 1.00 69.57  ? 59   VAL A CG1   1 ? 
ATOM   448  C CG2   . VAL A 1 57  ? 8.585   27.158  46.000 1.00 65.79  ? 59   VAL A CG2   1 ? 
ATOM   449  N N     . ALA A 1 58  ? 11.793  26.980  48.323 1.00 70.14  ? 60   ALA A N     1 ? 
ATOM   450  C CA    . ALA A 1 58  ? 12.928  27.923  48.410 1.00 66.41  ? 60   ALA A CA    1 ? 
ATOM   451  C C     . ALA A 1 58  ? 14.177  27.266  47.817 1.00 75.20  ? 60   ALA A C     1 ? 
ATOM   452  O O     . ALA A 1 58  ? 14.856  27.926  46.985 1.00 78.83  ? 60   ALA A O     1 ? 
ATOM   453  C CB    . ALA A 1 58  ? 13.160  28.335  49.839 1.00 67.21  ? 60   ALA A CB    1 ? 
ATOM   454  N N     . GLN A 1 59  ? 14.469  26.020  48.205 1.00 68.27  ? 61   GLN A N     1 ? 
ATOM   455  C CA    . GLN A 1 59  ? 15.643  25.287  47.663 1.00 63.31  ? 61   GLN A CA    1 ? 
ATOM   456  C C     . GLN A 1 59  ? 15.436  24.982  46.182 1.00 63.20  ? 61   GLN A C     1 ? 
ATOM   457  O O     . GLN A 1 59  ? 16.430  24.931  45.446 1.00 70.31  ? 61   GLN A O     1 ? 
ATOM   458  C CB    . GLN A 1 59  ? 15.880  24.001  48.437 1.00 67.69  ? 61   GLN A CB    1 ? 
ATOM   459  C CG    . GLN A 1 59  ? 17.261  23.412  48.206 1.00 71.99  ? 61   GLN A CG    1 ? 
ATOM   460  C CD    . GLN A 1 59  ? 18.349  24.387  48.566 1.00 81.13  ? 61   GLN A CD    1 ? 
ATOM   461  O OE1   . GLN A 1 59  ? 18.364  24.954  49.664 1.00 73.11  ? 61   GLN A OE1   1 ? 
ATOM   462  N NE2   . GLN A 1 59  ? 19.253  24.604  47.619 1.00 80.37  ? 61   GLN A NE2   1 ? 
ATOM   463  N N     . TYR A 1 60  ? 14.192  24.789  45.755 1.00 62.58  ? 62   TYR A N     1 ? 
ATOM   464  C CA    . TYR A 1 60  ? 13.867  24.586  44.326 1.00 62.36  ? 62   TYR A CA    1 ? 
ATOM   465  C C     . TYR A 1 60  ? 14.210  25.847  43.532 1.00 62.91  ? 62   TYR A C     1 ? 
ATOM   466  O O     . TYR A 1 60  ? 14.759  25.745  42.415 1.00 61.45  ? 62   TYR A O     1 ? 
ATOM   467  C CB    . TYR A 1 60  ? 12.396  24.222  44.144 1.00 64.96  ? 62   TYR A CB    1 ? 
ATOM   468  C CG    . TYR A 1 60  ? 12.035  23.870  42.721 1.00 63.88  ? 62   TYR A CG    1 ? 
ATOM   469  C CD1   . TYR A 1 60  ? 12.485  22.697  42.150 1.00 67.02  ? 62   TYR A CD1   1 ? 
ATOM   470  C CD2   . TYR A 1 60  ? 11.255  24.704  41.948 1.00 60.93  ? 62   TYR A CD2   1 ? 
ATOM   471  C CE1   . TYR A 1 60  ? 12.145  22.346  40.854 1.00 68.83  ? 62   TYR A CE1   1 ? 
ATOM   472  C CE2   . TYR A 1 60  ? 10.923  24.379  40.644 1.00 62.61  ? 62   TYR A CE2   1 ? 
ATOM   473  C CZ    . TYR A 1 60  ? 11.366  23.192  40.092 1.00 65.24  ? 62   TYR A CZ    1 ? 
ATOM   474  O OH    . TYR A 1 60  ? 11.054  22.837  38.814 1.00 59.67  ? 62   TYR A OH    1 ? 
ATOM   475  N N     . ILE A 1 61  ? 13.905  27.012  44.099 1.00 68.53  ? 63   ILE A N     1 ? 
ATOM   476  C CA    . ILE A 1 61  ? 14.186  28.315  43.427 1.00 70.38  ? 63   ILE A CA    1 ? 
ATOM   477  C C     . ILE A 1 61  ? 15.695  28.547  43.370 1.00 61.94  ? 63   ILE A C     1 ? 
ATOM   478  O O     . ILE A 1 61  ? 16.178  28.994  42.324 1.00 59.64  ? 63   ILE A O     1 ? 
ATOM   479  C CB    . ILE A 1 61  ? 13.454  29.464  44.127 1.00 68.19  ? 63   ILE A CB    1 ? 
ATOM   480  C CG1   . ILE A 1 61  ? 11.943  29.279  44.010 1.00 66.67  ? 63   ILE A CG1   1 ? 
ATOM   481  C CG2   . ILE A 1 61  ? 13.906  30.801  43.557 1.00 71.55  ? 63   ILE A CG2   1 ? 
ATOM   482  C CD1   . ILE A 1 61  ? 11.144  30.278  44.791 1.00 71.40  ? 63   ILE A CD1   1 ? 
ATOM   483  N N     . ARG A 1 62  ? 16.413  28.270  44.445 1.00 61.42  ? 64   ARG A N     1 ? 
ATOM   484  C CA    . ARG A 1 62  ? 17.883  28.438  44.424 1.00 64.92  ? 64   ARG A CA    1 ? 
ATOM   485  C C     . ARG A 1 62  ? 18.485  27.508  43.369 1.00 62.36  ? 64   ARG A C     1 ? 
ATOM   486  O O     . ARG A 1 62  ? 19.329  27.967  42.602 1.00 64.53  ? 64   ARG A O     1 ? 
ATOM   487  C CB    . ARG A 1 62  ? 18.448  28.197  45.824 1.00 65.50  ? 64   ARG A CB    1 ? 
ATOM   488  C CG    . ARG A 1 62  ? 17.940  29.180  46.866 1.00 70.32  ? 64   ARG A CG    1 ? 
ATOM   489  C CD    . ARG A 1 62  ? 18.560  28.919  48.220 1.00 72.20  ? 64   ARG A CD    1 ? 
ATOM   490  N NE    . ARG A 1 62  ? 17.718  29.460  49.272 1.00 79.11  ? 64   ARG A NE    1 ? 
ATOM   491  C CZ    . ARG A 1 62  ? 17.146  28.725  50.213 1.00 75.93  ? 64   ARG A CZ    1 ? 
ATOM   492  N NH1   . ARG A 1 62  ? 17.495  27.461  50.364 1.00 75.19  ? 64   ARG A NH1   1 ? 
ATOM   493  N NH2   . ARG A 1 62  ? 16.227  29.257  50.998 1.00 83.86  ? 64   ARG A NH2   1 ? 
ATOM   494  N N     . ASN A 1 63  ? 18.058  26.251  43.345 1.00 64.70  ? 65   ASN A N     1 ? 
ATOM   495  C CA    . ASN A 1 63  ? 18.563  25.282  42.349 1.00 65.56  ? 65   ASN A CA    1 ? 
ATOM   496  C C     . ASN A 1 63  ? 18.242  25.798  40.947 1.00 57.63  ? 65   ASN A C     1 ? 
ATOM   497  O O     . ASN A 1 63  ? 19.065  25.627  40.065 1.00 59.55  ? 65   ASN A O     1 ? 
ATOM   498  C CB    . ASN A 1 63  ? 17.993  23.888  42.614 1.00 68.43  ? 65   ASN A CB    1 ? 
ATOM   499  C CG    . ASN A 1 63  ? 18.513  23.264  43.893 1.00 69.62  ? 65   ASN A CG    1 ? 
ATOM   500  O OD1   . ASN A 1 63  ? 19.425  23.787  44.537 1.00 72.22  ? 65   ASN A OD1   1 ? 
ATOM   501  N ND2   . ASN A 1 63  ? 17.934  22.140  44.273 1.00 70.91  ? 65   ASN A ND2   1 ? 
ATOM   502  N N     . GLY A 1 64  ? 17.073  26.397  40.768 1.00 60.47  ? 66   GLY A N     1 ? 
ATOM   503  C CA    . GLY A 1 64  ? 16.666  26.937  39.463 1.00 65.64  ? 66   GLY A CA    1 ? 
ATOM   504  C C     . GLY A 1 64  ? 17.625  28.025  39.034 1.00 71.39  ? 66   GLY A C     1 ? 
ATOM   505  O O     . GLY A 1 64  ? 18.064  28.040  37.851 1.00 65.29  ? 66   GLY A O     1 ? 
ATOM   506  N N     . HIS A 1 65  ? 17.963  28.912  39.965 1.00 67.21  ? 67   HIS A N     1 ? 
ATOM   507  C CA    . HIS A 1 65  ? 18.899  30.030  39.693 1.00 61.52  ? 67   HIS A CA    1 ? 
ATOM   508  C C     . HIS A 1 65  ? 20.240  29.434  39.270 1.00 60.59  ? 67   HIS A C     1 ? 
ATOM   509  O O     . HIS A 1 65  ? 20.842  29.891  38.257 1.00 61.07  ? 67   HIS A O     1 ? 
ATOM   510  C CB    . HIS A 1 65  ? 19.060  30.941  40.918 1.00 63.97  ? 67   HIS A CB    1 ? 
ATOM   511  C CG    . HIS A 1 65  ? 17.980  31.952  41.078 1.00 64.02  ? 67   HIS A CG    1 ? 
ATOM   512  N ND1   . HIS A 1 65  ? 17.371  32.206  42.295 1.00 55.61  ? 67   HIS A ND1   1 ? 
ATOM   513  C CD2   . HIS A 1 65  ? 17.389  32.765  40.176 1.00 66.73  ? 67   HIS A CD2   1 ? 
ATOM   514  C CE1   . HIS A 1 65  ? 16.459  33.138  42.128 1.00 58.55  ? 67   HIS A CE1   1 ? 
ATOM   515  N NE2   . HIS A 1 65  ? 16.447  33.490  40.843 1.00 64.45  ? 67   HIS A NE2   1 ? 
ATOM   516  N N     . GLU A 1 66  ? 20.706  28.435  40.000 1.00 59.13  ? 68   GLU A N     1 ? 
ATOM   517  C CA    . GLU A 1 66  ? 22.012  27.812  39.687 1.00 61.64  ? 68   GLU A CA    1 ? 
ATOM   518  C C     . GLU A 1 66  ? 21.966  27.183  38.294 1.00 69.06  ? 68   GLU A C     1 ? 
ATOM   519  O O     . GLU A 1 66  ? 22.956  27.323  37.551 1.00 67.79  ? 68   GLU A O     1 ? 
ATOM   520  C CB    . GLU A 1 66  ? 22.361  26.784  40.750 1.00 59.05  ? 68   GLU A CB    1 ? 
ATOM   521  C CG    . GLU A 1 66  ? 23.635  26.022  40.447 1.00 67.74  ? 68   GLU A CG    1 ? 
ATOM   522  C CD    . GLU A 1 66  ? 24.156  25.196  41.622 1.00 74.58  ? 68   GLU A CD    1 ? 
ATOM   523  O OE1   . GLU A 1 66  ? 23.383  24.946  42.562 1.00 71.99  ? 68   GLU A OE1   1 ? 
ATOM   524  O OE2   . GLU A 1 66  ? 25.346  24.825  41.600 1.00 75.42  ? 68   GLU A OE2   1 ? 
ATOM   525  N N     . LEU A 1 67  ? 20.857  26.520  37.960 1.00 73.48  ? 69   LEU A N     1 ? 
ATOM   526  C CA    . LEU A 1 67  ? 20.737  25.767  36.690 1.00 65.62  ? 69   LEU A CA    1 ? 
ATOM   527  C C     . LEU A 1 67  ? 20.567  26.730  35.519 1.00 64.71  ? 69   LEU A C     1 ? 
ATOM   528  O O     . LEU A 1 67  ? 21.176  26.464  34.467 1.00 65.74  ? 69   LEU A O     1 ? 
ATOM   529  C CB    . LEU A 1 67  ? 19.583  24.765  36.771 1.00 58.81  ? 69   LEU A CB    1 ? 
ATOM   530  C CG    . LEU A 1 67  ? 19.840  23.595  37.713 1.00 62.41  ? 69   LEU A CG    1 ? 
ATOM   531  C CD1   . LEU A 1 67  ? 18.644  22.649  37.725 1.00 66.36  ? 69   LEU A CD1   1 ? 
ATOM   532  C CD2   . LEU A 1 67  ? 21.118  22.855  37.335 1.00 59.60  ? 69   LEU A CD2   1 ? 
ATOM   533  N N     . LEU A 1 68  ? 19.780  27.797  35.676 1.00 65.35  ? 70   LEU A N     1 ? 
ATOM   534  C CA    . LEU A 1 68  ? 19.623  28.768  34.565 1.00 70.43  ? 70   LEU A CA    1 ? 
ATOM   535  C C     . LEU A 1 68  ? 20.940  29.511  34.357 1.00 76.59  ? 70   LEU A C     1 ? 
ATOM   536  O O     . LEU A 1 68  ? 21.223  29.830  33.179 1.00 76.63  ? 70   LEU A O     1 ? 
ATOM   537  C CB    . LEU A 1 68  ? 18.493  29.765  34.815 1.00 67.69  ? 70   LEU A CB    1 ? 
ATOM   538  C CG    . LEU A 1 68  ? 17.068  29.207  34.868 1.00 68.65  ? 70   LEU A CG    1 ? 
ATOM   539  C CD1   . LEU A 1 68  ? 16.339  29.741  36.086 1.00 63.78  ? 70   LEU A CD1   1 ? 
ATOM   540  C CD2   . LEU A 1 68  ? 16.293  29.579  33.606 1.00 76.93  ? 70   LEU A CD2   1 ? 
ATOM   541  N N     . ALA A 1 69  ? 21.706  29.774  35.424 1.00 78.52  ? 71   ALA A N     1 ? 
ATOM   542  C CA    . ALA A 1 69  ? 23.080  30.317  35.283 1.00 70.34  ? 71   ALA A CA    1 ? 
ATOM   543  C C     . ALA A 1 69  ? 23.890  29.333  34.426 1.00 74.58  ? 71   ALA A C     1 ? 
ATOM   544  O O     . ALA A 1 69  ? 24.486  29.773  33.416 1.00 72.70  ? 71   ALA A O     1 ? 
ATOM   545  C CB    . ALA A 1 69  ? 23.720  30.569  36.627 1.00 68.83  ? 71   ALA A CB    1 ? 
ATOM   546  N N     . ARG A 1 70  ? 23.872  28.045  34.784 1.00 77.75  ? 72   ARG A N     1 ? 
ATOM   547  C CA    . ARG A 1 70  ? 24.704  27.026  34.093 1.00 74.31  ? 72   ARG A CA    1 ? 
ATOM   548  C C     . ARG A 1 70  ? 24.267  26.883  32.634 1.00 81.38  ? 72   ARG A C     1 ? 
ATOM   549  O O     . ARG A 1 70  ? 25.147  26.682  31.763 1.00 78.04  ? 72   ARG A O     1 ? 
ATOM   550  C CB    . ARG A 1 70  ? 24.620  25.682  34.811 1.00 74.80  ? 72   ARG A CB    1 ? 
ATOM   551  C CG    . ARG A 1 70  ? 25.606  24.654  34.282 1.00 85.90  ? 72   ARG A CG    1 ? 
ATOM   552  C CD    . ARG A 1 70  ? 25.603  23.394  35.136 1.00 90.66  ? 72   ARG A CD    1 ? 
ATOM   553  N NE    . ARG A 1 70  ? 25.994  23.677  36.518 1.00 99.65  ? 72   ARG A NE    1 ? 
ATOM   554  C CZ    . ARG A 1 70  ? 25.782  22.860  37.551 1.00 93.74  ? 72   ARG A CZ    1 ? 
ATOM   555  N NH1   . ARG A 1 70  ? 25.175  21.692  37.381 1.00 87.08  ? 72   ARG A NH1   1 ? 
ATOM   556  N NH2   . ARG A 1 70  ? 26.176  23.226  38.757 1.00 85.50  ? 72   ARG A NH2   1 ? 
ATOM   557  N N     . GLU A 1 71  ? 22.961  26.970  32.379 1.00 84.65  ? 73   GLU A N     1 ? 
ATOM   558  C CA    . GLU A 1 71  ? 22.381  26.746  31.029 1.00 82.70  ? 73   GLU A CA    1 ? 
ATOM   559  C C     . GLU A 1 71  ? 22.698  27.923  30.105 1.00 84.25  ? 73   GLU A C     1 ? 
ATOM   560  O O     . GLU A 1 71  ? 22.745  27.691  28.876 1.00 88.14  ? 73   GLU A O     1 ? 
ATOM   561  C CB    . GLU A 1 71  ? 20.870  26.552  31.118 1.00 81.50  ? 73   GLU A CB    1 ? 
ATOM   562  C CG    . GLU A 1 71  ? 20.240  26.110  29.809 1.00 83.53  ? 73   GLU A CG    1 ? 
ATOM   563  C CD    . GLU A 1 71  ? 19.778  27.260  28.929 1.00 87.93  ? 73   GLU A CD    1 ? 
ATOM   564  O OE1   . GLU A 1 71  ? 19.913  27.154  27.680 1.00 85.05  ? 73   GLU A OE1   1 ? 
ATOM   565  O OE2   . GLU A 1 71  ? 19.296  28.268  29.495 1.00 82.91  ? 73   GLU A OE2   1 ? 
ATOM   566  N N     . SER A 1 72  ? 22.902  29.124  30.658 1.00 81.64  ? 74   SER A N     1 ? 
ATOM   567  C CA    . SER A 1 72  ? 23.241  30.324  29.839 1.00 90.15  ? 74   SER A CA    1 ? 
ATOM   568  C C     . SER A 1 72  ? 24.658  30.202  29.263 1.00 86.05  ? 74   SER A C     1 ? 
ATOM   569  O O     . SER A 1 72  ? 24.959  30.906  28.288 1.00 75.68  ? 74   SER A O     1 ? 
ATOM   570  C CB    . SER A 1 72  ? 23.121  31.582  30.644 1.00 93.74  ? 74   SER A CB    1 ? 
ATOM   571  O OG    . SER A 1 72  ? 24.246  31.709  31.515 1.00 91.25  ? 74   SER A OG    1 ? 
ATOM   572  N N     . GLU A 1 73  ? 25.497  29.368  29.873 1.00 89.28  ? 75   GLU A N     1 ? 
ATOM   573  C CA    . GLU A 1 73  ? 26.904  29.174  29.454 1.00 86.72  ? 75   GLU A CA    1 ? 
ATOM   574  C C     . GLU A 1 73  ? 26.970  28.066  28.401 1.00 95.53  ? 75   GLU A C     1 ? 
ATOM   575  O O     . GLU A 1 73  ? 26.057  27.196  28.343 1.00 92.76  ? 75   GLU A O     1 ? 
ATOM   576  C CB    . GLU A 1 73  ? 27.785  28.802  30.651 1.00 88.30  ? 75   GLU A CB    1 ? 
ATOM   577  C CG    . GLU A 1 73  ? 27.604  29.695  31.872 1.00 91.12  ? 75   GLU A CG    1 ? 
ATOM   578  C CD    . GLU A 1 73  ? 28.314  31.039  31.801 1.00 90.93  ? 75   GLU A CD    1 ? 
ATOM   579  O OE1   . GLU A 1 73  ? 29.291  31.165  31.009 1.00 88.11  ? 75   GLU A OE1   1 ? 
ATOM   580  O OE2   . GLU A 1 73  ? 27.870  31.959  32.521 1.00 82.41  ? 75   GLU A OE2   1 ? 
ATOM   581  N N     . GLU A 1 74  ? 28.030  28.093  27.603 1.00 92.91  ? 76   GLU A N     1 ? 
ATOM   582  C CA    . GLU A 1 74  ? 28.288  27.040  26.599 1.00 94.93  ? 76   GLU A CA    1 ? 
ATOM   583  C C     . GLU A 1 74  ? 28.985  25.884  27.293 1.00 94.00  ? 76   GLU A C     1 ? 
ATOM   584  O O     . GLU A 1 74  ? 29.991  26.114  27.970 1.00 101.13 ? 76   GLU A O     1 ? 
ATOM   585  C CB    . GLU A 1 74  ? 29.120  27.573  25.445 1.00 96.11  ? 76   GLU A CB    1 ? 
ATOM   586  C CG    . GLU A 1 74  ? 28.328  28.512  24.561 1.00 106.99 ? 76   GLU A CG    1 ? 
ATOM   587  C CD    . GLU A 1 74  ? 29.149  29.084  23.420 1.00 113.07 ? 76   GLU A CD    1 ? 
ATOM   588  O OE1   . GLU A 1 74  ? 30.254  28.539  23.150 1.00 111.35 ? 76   GLU A OE1   1 ? 
ATOM   589  O OE2   . GLU A 1 74  ? 28.690  30.078  22.811 1.00 108.82 ? 76   GLU A OE2   1 ? 
ATOM   590  N N     . VAL A 1 75  ? 28.431  24.693  27.148 1.00 97.31  ? 77   VAL A N     1 ? 
ATOM   591  C CA    . VAL A 1 75  ? 28.926  23.512  27.901 1.00 106.80 ? 77   VAL A CA    1 ? 
ATOM   592  C C     . VAL A 1 75  ? 30.293  23.136  27.329 1.00 104.68 ? 77   VAL A C     1 ? 
ATOM   593  O O     . VAL A 1 75  ? 30.482  23.232  26.095 1.00 99.88  ? 77   VAL A O     1 ? 
ATOM   594  C CB    . VAL A 1 75  ? 27.923  22.349  27.841 1.00 112.72 ? 77   VAL A CB    1 ? 
ATOM   595  C CG1   . VAL A 1 75  ? 27.583  21.986  26.399 1.00 105.95 ? 77   VAL A CG1   1 ? 
ATOM   596  C CG2   . VAL A 1 75  ? 28.438  21.143  28.621 1.00 108.91 ? 77   VAL A CG2   1 ? 
ATOM   597  N N     . ASP A 1 76  ? 31.215  22.771  28.214 1.00 103.64 ? 78   ASP A N     1 ? 
ATOM   598  C CA    . ASP A 1 76  ? 32.574  22.331  27.824 1.00 109.58 ? 78   ASP A CA    1 ? 
ATOM   599  C C     . ASP A 1 76  ? 32.985  21.161  28.706 1.00 100.27 ? 78   ASP A C     1 ? 
ATOM   600  O O     . ASP A 1 76  ? 32.755  21.199  29.930 1.00 102.79 ? 78   ASP A O     1 ? 
ATOM   601  C CB    . ASP A 1 76  ? 33.631  23.435  27.941 1.00 116.90 ? 78   ASP A CB    1 ? 
ATOM   602  C CG    . ASP A 1 76  ? 35.058  22.881  27.969 1.00 117.45 ? 78   ASP A CG    1 ? 
ATOM   603  O OD1   . ASP A 1 76  ? 35.643  22.661  26.868 1.00 102.83 ? 78   ASP A OD1   1 ? 
ATOM   604  O OD2   . ASP A 1 76  ? 35.577  22.633  29.094 1.00 109.68 ? 78   ASP A OD2   1 ? 
ATOM   605  N N     . PHE A 1 77  ? 33.621  20.181  28.088 1.00 97.02  ? 79   PHE A N     1 ? 
ATOM   606  C CA    . PHE A 1 77  ? 34.236  19.044  28.798 1.00 97.64  ? 79   PHE A CA    1 ? 
ATOM   607  C C     . PHE A 1 77  ? 35.747  19.191  28.675 1.00 90.33  ? 79   PHE A C     1 ? 
ATOM   608  O O     . PHE A 1 77  ? 36.253  19.468  27.580 1.00 92.76  ? 79   PHE A O     1 ? 
ATOM   609  C CB    . PHE A 1 77  ? 33.720  17.724  28.228 1.00 100.80 ? 79   PHE A CB    1 ? 
ATOM   610  C CG    . PHE A 1 77  ? 32.283  17.426  28.566 1.00 109.25 ? 79   PHE A CG    1 ? 
ATOM   611  C CD1   . PHE A 1 77  ? 31.942  16.890  29.799 1.00 109.05 ? 79   PHE A CD1   1 ? 
ATOM   612  C CD2   . PHE A 1 77  ? 31.272  17.694  27.653 1.00 115.15 ? 79   PHE A CD2   1 ? 
ATOM   613  C CE1   . PHE A 1 77  ? 30.618  16.622  30.112 1.00 105.15 ? 79   PHE A CE1   1 ? 
ATOM   614  C CE2   . PHE A 1 77  ? 29.949  17.425  27.967 1.00 114.03 ? 79   PHE A CE2   1 ? 
ATOM   615  C CZ    . PHE A 1 77  ? 29.625  16.895  29.198 1.00 104.80 ? 79   PHE A CZ    1 ? 
ATOM   616  N N     . ALA A 1 78  ? 36.448  19.041  29.787 1.00 97.52  ? 80   ALA A N     1 ? 
ATOM   617  C CA    . ALA A 1 78  ? 37.928  19.063  29.797 1.00 107.27 ? 80   ALA A CA    1 ? 
ATOM   618  C C     . ALA A 1 78  ? 38.455  17.893  28.952 1.00 108.32 ? 80   ALA A C     1 ? 
ATOM   619  O O     . ALA A 1 78  ? 39.414  18.105  28.171 1.00 102.38 ? 80   ALA A O     1 ? 
ATOM   620  C CB    . ALA A 1 78  ? 38.459  19.023  31.211 1.00 97.62  ? 80   ALA A CB    1 ? 
ATOM   621  N N     . ALA A 1 79  ? 37.846  16.714  29.087 1.00 101.24 ? 81   ALA A N     1 ? 
ATOM   622  C CA    . ALA A 1 79  ? 38.250  15.494  28.354 1.00 101.84 ? 81   ALA A CA    1 ? 
ATOM   623  C C     . ALA A 1 79  ? 37.025  14.642  28.027 1.00 98.68  ? 81   ALA A C     1 ? 
ATOM   624  O O     . ALA A 1 79  ? 36.127  14.468  28.892 1.00 93.93  ? 81   ALA A O     1 ? 
ATOM   625  C CB    . ALA A 1 79  ? 39.241  14.696  29.159 0.30 109.98 ? 81   ALA A CB    1 ? 
ATOM   626  N N     . LEU A 1 80  ? 37.026  14.075  26.830 1.00 98.84  ? 82   LEU A N     1 ? 
ATOM   627  C CA    . LEU A 1 80  ? 35.873  13.296  26.325 1.00 95.60  ? 82   LEU A CA    1 ? 
ATOM   628  C C     . LEU A 1 80  ? 36.386  12.193  25.402 1.00 97.76  ? 82   LEU A C     1 ? 
ATOM   629  O O     . LEU A 1 80  ? 36.830  12.504  24.273 1.00 97.64  ? 82   LEU A O     1 ? 
ATOM   630  C CB    . LEU A 1 80  ? 34.925  14.253  25.605 1.00 91.46  ? 82   LEU A CB    1 ? 
ATOM   631  C CG    . LEU A 1 80  ? 33.464  13.819  25.539 1.00 91.75  ? 82   LEU A CG    1 ? 
ATOM   632  C CD1   . LEU A 1 80  ? 32.546  15.021  25.634 1.00 88.20  ? 82   LEU A CD1   1 ? 
ATOM   633  C CD2   . LEU A 1 80  ? 33.200  13.063  24.250 1.00 96.45  ? 82   LEU A CD2   1 ? 
ATOM   634  N N     . GLU A 1 81  ? 36.351  10.955  25.888 1.00 96.20  ? 83   GLU A N     1 ? 
ATOM   635  C CA    . GLU A 1 81  ? 37.005  9.812   25.217 1.00 96.33  ? 83   GLU A CA    1 ? 
ATOM   636  C C     . GLU A 1 81  ? 36.060  8.619   25.214 1.00 91.41  ? 83   GLU A C     1 ? 
ATOM   637  O O     . GLU A 1 81  ? 34.983  8.687   25.822 1.00 94.47  ? 83   GLU A O     1 ? 
ATOM   638  C CB    . GLU A 1 81  ? 38.289  9.417   25.948 1.00 104.98 ? 83   GLU A CB    1 ? 
ATOM   639  C CG    . GLU A 1 81  ? 39.493  10.272  25.607 1.00 116.47 ? 83   GLU A CG    1 ? 
ATOM   640  C CD    . GLU A 1 81  ? 40.701  9.923   26.463 1.00 119.47 ? 83   GLU A CD    1 ? 
ATOM   641  O OE1   . GLU A 1 81  ? 40.580  8.967   27.294 1.00 101.10 ? 83   GLU A OE1   1 ? 
ATOM   642  O OE2   . GLU A 1 81  ? 41.747  10.611  26.318 1.00 121.45 ? 83   GLU A OE2   1 ? 
ATOM   643  N N     . MET A 1 82  ? 36.501  7.561   24.550 1.00 93.76  ? 84   MET A N     1 ? 
ATOM   644  C CA    . MET A 1 82  ? 35.826  6.248   24.543 1.00 89.84  ? 84   MET A CA    1 ? 
ATOM   645  C C     . MET A 1 82  ? 35.879  5.680   25.952 1.00 97.42  ? 84   MET A C     1 ? 
ATOM   646  O O     . MET A 1 82  ? 36.898  5.786   26.634 1.00 102.58 ? 84   MET A O     1 ? 
ATOM   647  C CB    . MET A 1 82  ? 36.536  5.285   23.587 1.00 94.70  ? 84   MET A CB    1 ? 
ATOM   648  C CG    . MET A 1 82  ? 35.702  4.085   23.172 1.00 93.08  ? 84   MET A CG    1 ? 
ATOM   649  S SD    . MET A 1 82  ? 34.150  4.502   22.363 1.00 94.37  ? 84   MET A SD    1 ? 
ATOM   650  C CE    . MET A 1 82  ? 34.713  4.666   20.662 1.00 103.86 ? 84   MET A CE    1 ? 
ATOM   651  N N     . PRO A 1 83  ? 34.768  5.099   26.446 1.00 97.04  ? 85   PRO A N     1 ? 
ATOM   652  C CA    . PRO A 1 83  ? 34.789  4.399   27.729 1.00 88.54  ? 85   PRO A CA    1 ? 
ATOM   653  C C     . PRO A 1 83  ? 35.773  3.236   27.667 1.00 90.16  ? 85   PRO A C     1 ? 
ATOM   654  O O     . PRO A 1 83  ? 35.897  2.560   26.639 1.00 88.23  ? 85   PRO A O     1 ? 
ATOM   655  C CB    . PRO A 1 83  ? 33.349  3.917   27.914 1.00 85.40  ? 85   PRO A CB    1 ? 
ATOM   656  C CG    . PRO A 1 83  ? 32.536  4.825   27.016 1.00 89.19  ? 85   PRO A CG    1 ? 
ATOM   657  C CD    . PRO A 1 83  ? 33.431  5.130   25.836 1.00 90.53  ? 85   PRO A CD    1 ? 
ATOM   658  N N     . PRO A 1 84  ? 36.560  3.004   28.735 1.00 84.67  ? 86   PRO A N     1 ? 
ATOM   659  C CA    . PRO A 1 84  ? 37.480  1.868   28.748 1.00 91.68  ? 86   PRO A CA    1 ? 
ATOM   660  C C     . PRO A 1 84  ? 36.757  0.515   28.603 1.00 89.35  ? 86   PRO A C     1 ? 
ATOM   661  O O     . PRO A 1 84  ? 37.251  -0.348  27.901 1.00 86.73  ? 86   PRO A O     1 ? 
ATOM   662  C CB    . PRO A 1 84  ? 38.189  2.001   30.108 1.00 84.83  ? 86   PRO A CB    1 ? 
ATOM   663  C CG    . PRO A 1 84  ? 38.009  3.456   30.477 1.00 82.09  ? 86   PRO A CG    1 ? 
ATOM   664  C CD    . PRO A 1 84  ? 36.647  3.826   29.947 1.00 84.45  ? 86   PRO A CD    1 ? 
ATOM   665  N N     . LEU A 1 85  ? 35.588  0.372   29.235 1.00 85.04  ? 87   LEU A N     1 ? 
ATOM   666  C CA    . LEU A 1 85  ? 34.901  -0.941  29.332 1.00 81.66  ? 87   LEU A CA    1 ? 
ATOM   667  C C     . LEU A 1 85  ? 33.729  -0.978  28.367 1.00 78.43  ? 87   LEU A C     1 ? 
ATOM   668  O O     . LEU A 1 85  ? 32.603  -0.707  28.785 1.00 80.77  ? 87   LEU A O     1 ? 
ATOM   669  C CB    . LEU A 1 85  ? 34.442  -1.171  30.768 1.00 80.38  ? 87   LEU A CB    1 ? 
ATOM   670  C CG    . LEU A 1 85  ? 35.562  -1.164  31.799 1.00 79.19  ? 87   LEU A CG    1 ? 
ATOM   671  C CD1   . LEU A 1 85  ? 34.988  -1.345  33.196 1.00 76.80  ? 87   LEU A CD1   1 ? 
ATOM   672  C CD2   . LEU A 1 85  ? 36.582  -2.254  31.483 1.00 83.80  ? 87   LEU A CD2   1 ? 
ATOM   673  N N     . ILE A 1 86  ? 34.028  -1.284  27.116 1.00 79.72  ? 88   ILE A N     1 ? 
ATOM   674  C CA    . ILE A 1 86  ? 33.021  -1.455  26.044 1.00 73.14  ? 88   ILE A CA    1 ? 
ATOM   675  C C     . ILE A 1 86  ? 33.138  -2.889  25.566 1.00 82.91  ? 88   ILE A C     1 ? 
ATOM   676  O O     . ILE A 1 86  ? 34.294  -3.361  25.353 1.00 82.60  ? 88   ILE A O     1 ? 
ATOM   677  C CB    . ILE A 1 86  ? 33.228  -0.447  24.913 1.00 74.09  ? 88   ILE A CB    1 ? 
ATOM   678  C CG1   . ILE A 1 86  ? 33.014  0.976   25.428 1.00 81.45  ? 88   ILE A CG1   1 ? 
ATOM   679  C CG2   . ILE A 1 86  ? 32.309  -0.762  23.747 1.00 73.63  ? 88   ILE A CG2   1 ? 
ATOM   680  C CD1   . ILE A 1 86  ? 31.718  1.149   26.178 1.00 83.50  ? 88   ILE A CD1   1 ? 
ATOM   681  N N     . PHE A 1 87  ? 31.993  -3.556  25.444 1.00 76.78  ? 89   PHE A N     1 ? 
ATOM   682  C CA    . PHE A 1 87  ? 31.930  -4.980  25.049 1.00 75.66  ? 89   PHE A CA    1 ? 
ATOM   683  C C     . PHE A 1 87  ? 30.880  -5.180  23.971 1.00 70.36  ? 89   PHE A C     1 ? 
ATOM   684  O O     . PHE A 1 87  ? 29.760  -4.693  24.116 1.00 80.54  ? 89   PHE A O     1 ? 
ATOM   685  C CB    . PHE A 1 87  ? 31.619  -5.846  26.260 1.00 75.69  ? 89   PHE A CB    1 ? 
ATOM   686  C CG    . PHE A 1 87  ? 32.434  -5.498  27.470 1.00 77.28  ? 89   PHE A CG    1 ? 
ATOM   687  C CD1   . PHE A 1 87  ? 33.756  -5.902  27.583 1.00 83.94  ? 89   PHE A CD1   1 ? 
ATOM   688  C CD2   . PHE A 1 87  ? 31.880  -4.745  28.485 1.00 80.86  ? 89   PHE A CD2   1 ? 
ATOM   689  C CE1   . PHE A 1 87  ? 34.500  -5.570  28.704 1.00 83.58  ? 89   PHE A CE1   1 ? 
ATOM   690  C CE2   . PHE A 1 87  ? 32.627  -4.415  29.605 1.00 83.24  ? 89   PHE A CE2   1 ? 
ATOM   691  C CZ    . PHE A 1 87  ? 33.929  -4.835  29.716 1.00 81.76  ? 89   PHE A CZ    1 ? 
ATOM   692  N N     . GLU A 1 88  ? 31.253  -5.894  22.924 1.00 70.81  ? 90   GLU A N     1 ? 
ATOM   693  C CA    . GLU A 1 88  ? 30.396  -6.069  21.736 1.00 71.36  ? 90   GLU A CA    1 ? 
ATOM   694  C C     . GLU A 1 88  ? 29.525  -7.305  21.941 1.00 73.76  ? 90   GLU A C     1 ? 
ATOM   695  O O     . GLU A 1 88  ? 30.069  -8.409  22.110 1.00 71.70  ? 90   GLU A O     1 ? 
ATOM   696  C CB    . GLU A 1 88  ? 31.254  -6.222  20.486 1.00 77.18  ? 90   GLU A CB    1 ? 
ATOM   697  C CG    . GLU A 1 88  ? 30.534  -5.854  19.214 1.00 90.03  ? 90   GLU A CG    1 ? 
ATOM   698  C CD    . GLU A 1 88  ? 31.486  -5.426  18.111 1.00 101.98 ? 90   GLU A CD    1 ? 
ATOM   699  O OE1   . GLU A 1 88  ? 32.660  -5.052  18.438 1.00 87.60  ? 90   GLU A OE1   1 ? 
ATOM   700  O OE2   . GLU A 1 88  ? 31.048  -5.464  16.925 1.00 104.66 ? 90   GLU A OE2   1 ? 
ATOM   701  N N     . ALA A 1 89  ? 28.209  -7.126  21.913 1.00 68.45  ? 91   ALA A N     1 ? 
ATOM   702  C CA    . ALA A 1 89  ? 27.266  -8.255  22.083 1.00 62.70  ? 91   ALA A CA    1 ? 
ATOM   703  C C     . ALA A 1 89  ? 27.161  -9.037  20.786 1.00 60.19  ? 91   ALA A C     1 ? 
ATOM   704  O O     . ALA A 1 89  ? 27.179  -8.464  19.692 1.00 67.90  ? 91   ALA A O     1 ? 
ATOM   705  C CB    . ALA A 1 89  ? 25.924  -7.759  22.502 1.00 59.50  ? 91   ALA A CB    1 ? 
ATOM   706  N N     . PRO A 1 90  ? 27.063  -10.372 20.862 1.00 55.39  ? 92   PRO A N     1 ? 
ATOM   707  C CA    . PRO A 1 90  ? 26.896  -11.169 19.663 1.00 57.30  ? 92   PRO A CA    1 ? 
ATOM   708  C C     . PRO A 1 90  ? 25.495  -11.020 19.067 1.00 53.02  ? 92   PRO A C     1 ? 
ATOM   709  O O     . PRO A 1 90  ? 24.582  -10.600 19.735 1.00 55.50  ? 92   PRO A O     1 ? 
ATOM   710  C CB    . PRO A 1 90  ? 27.154  -12.605 20.128 1.00 59.77  ? 92   PRO A CB    1 ? 
ATOM   711  C CG    . PRO A 1 90  ? 26.808  -12.579 21.587 1.00 62.57  ? 92   PRO A CG    1 ? 
ATOM   712  C CD    . PRO A 1 90  ? 27.172  -11.193 22.071 1.00 63.87  ? 92   PRO A CD    1 ? 
ATOM   713  N N     . SER A 1 91  ? 25.383  -11.389 17.807 1.00 58.61  ? 93   SER A N     1 ? 
ATOM   714  C CA    . SER A 1 91  ? 24.121  -11.252 17.047 1.00 59.44  ? 93   SER A CA    1 ? 
ATOM   715  C C     . SER A 1 91  ? 22.995  -12.059 17.700 1.00 60.63  ? 93   SER A C     1 ? 
ATOM   716  O O     . SER A 1 91  ? 23.235  -13.187 18.151 1.00 64.03  ? 93   SER A O     1 ? 
ATOM   717  C CB    . SER A 1 91  ? 24.303  -11.667 15.650 1.00 58.56  ? 93   SER A CB    1 ? 
ATOM   718  O OG    . SER A 1 91  ? 23.034  -11.644 15.006 1.00 66.10  ? 93   SER A OG    1 ? 
ATOM   719  N N     . LEU A 1 92  ? 21.796  -11.488 17.716 1.00 61.20  ? 94   LEU A N     1 ? 
ATOM   720  C CA    . LEU A 1 92  ? 20.596  -12.157 18.275 1.00 58.81  ? 94   LEU A CA    1 ? 
ATOM   721  C C     . LEU A 1 92  ? 20.006  -13.150 17.274 1.00 54.20  ? 94   LEU A C     1 ? 
ATOM   722  O O     . LEU A 1 92  ? 19.098  -13.879 17.697 1.00 55.50  ? 94   LEU A O     1 ? 
ATOM   723  C CB    . LEU A 1 92  ? 19.541  -11.120 18.681 1.00 57.13  ? 94   LEU A CB    1 ? 
ATOM   724  C CG    . LEU A 1 92  ? 18.931  -10.238 17.576 1.00 56.49  ? 94   LEU A CG    1 ? 
ATOM   725  C CD1   . LEU A 1 92  ? 17.745  -10.888 16.878 1.00 55.46  ? 94   LEU A CD1   1 ? 
ATOM   726  C CD2   . LEU A 1 92  ? 18.461  -8.925  18.169 1.00 61.46  ? 94   LEU A CD2   1 ? 
ATOM   727  N N     . HIS A 1 93  ? 20.438  -13.155 16.010 1.00 54.43  ? 95   HIS A N     1 ? 
ATOM   728  C CA    . HIS A 1 93  ? 19.904  -14.110 14.998 1.00 59.69  ? 95   HIS A CA    1 ? 
ATOM   729  C C     . HIS A 1 93  ? 20.924  -15.182 14.592 1.00 62.46  ? 95   HIS A C     1 ? 
ATOM   730  O O     . HIS A 1 93  ? 20.651  -15.920 13.612 1.00 64.25  ? 95   HIS A O     1 ? 
ATOM   731  C CB    . HIS A 1 93  ? 19.406  -13.363 13.781 1.00 63.42  ? 95   HIS A CB    1 ? 
ATOM   732  C CG    . HIS A 1 93  ? 20.466  -12.603 13.072 1.00 70.14  ? 95   HIS A CG    1 ? 
ATOM   733  N ND1   . HIS A 1 93  ? 21.320  -13.195 12.172 1.00 69.42  ? 95   HIS A ND1   1 ? 
ATOM   734  C CD2   . HIS A 1 93  ? 20.785  -11.297 13.107 1.00 72.74  ? 95   HIS A CD2   1 ? 
ATOM   735  C CE1   . HIS A 1 93  ? 22.146  -12.297 11.703 1.00 72.94  ? 95   HIS A CE1   1 ? 
ATOM   736  N NE2   . HIS A 1 93  ? 21.837  -11.126 12.257 1.00 81.57  ? 95   HIS A NE2   1 ? 
ATOM   737  N N     . ARG A 1 94  ? 22.048  -15.263 15.302 1.00 62.43  ? 96   ARG A N     1 ? 
ATOM   738  C CA    . ARG A 1 94  ? 23.056  -16.325 15.079 1.00 61.84  ? 96   ARG A CA    1 ? 
ATOM   739  C C     . ARG A 1 94  ? 23.177  -17.153 16.359 1.00 57.91  ? 96   ARG A C     1 ? 
ATOM   740  O O     . ARG A 1 94  ? 23.544  -16.637 17.435 1.00 61.88  ? 96   ARG A O     1 ? 
ATOM   741  C CB    . ARG A 1 94  ? 24.406  -15.735 14.671 1.00 72.11  ? 96   ARG A CB    1 ? 
ATOM   742  C CG    . ARG A 1 94  ? 24.369  -14.880 13.414 1.00 72.42  ? 96   ARG A CG    1 ? 
ATOM   743  C CD    . ARG A 1 94  ? 25.768  -14.417 13.023 1.00 75.30  ? 96   ARG A CD    1 ? 
ATOM   744  N NE    . ARG A 1 94  ? 25.760  -13.618 11.795 1.00 84.99  ? 96   ARG A NE    1 ? 
ATOM   745  C CZ    . ARG A 1 94  ? 26.013  -12.306 11.721 1.00 88.74  ? 96   ARG A CZ    1 ? 
ATOM   746  N NH1   . ARG A 1 94  ? 26.339  -11.610 12.808 1.00 79.14  ? 96   ARG A NH1   1 ? 
ATOM   747  N NH2   . ARG A 1 94  ? 25.958  -11.703 10.542 1.00 73.80  ? 96   ARG A NH2   1 ? 
ATOM   748  N N     . ARG A 1 95  ? 22.919  -18.441 16.226 1.00 55.51  ? 97   ARG A N     1 ? 
ATOM   749  C CA    . ARG A 1 95  ? 22.976  -19.356 17.391 1.00 63.27  ? 97   ARG A CA    1 ? 
ATOM   750  C C     . ARG A 1 95  ? 24.397  -19.851 17.581 1.00 59.39  ? 97   ARG A C     1 ? 
ATOM   751  O O     . ARG A 1 95  ? 24.646  -21.057 17.410 1.00 71.19  ? 97   ARG A O     1 ? 
ATOM   752  C CB    . ARG A 1 95  ? 21.998  -20.502 17.206 1.00 61.14  ? 97   ARG A CB    1 ? 
ATOM   753  C CG    . ARG A 1 95  ? 21.649  -21.191 18.513 1.00 60.01  ? 97   ARG A CG    1 ? 
ATOM   754  C CD    . ARG A 1 95  ? 20.676  -22.323 18.258 1.00 60.25  ? 97   ARG A CD    1 ? 
ATOM   755  N NE    . ARG A 1 95  ? 20.113  -22.839 19.490 1.00 62.36  ? 97   ARG A NE    1 ? 
ATOM   756  C CZ    . ARG A 1 95  ? 19.340  -23.924 19.583 1.00 63.23  ? 97   ARG A CZ    1 ? 
ATOM   757  N NH1   . ARG A 1 95  ? 19.034  -24.618 18.495 1.00 62.65  ? 97   ARG A NH1   1 ? 
ATOM   758  N NH2   . ARG A 1 95  ? 18.899  -24.318 20.774 1.00 57.70  ? 97   ARG A NH2   1 ? 
ATOM   759  N N     . THR A 1 96  ? 25.283  -18.940 17.960 1.00 62.45  ? 98   THR A N     1 ? 
ATOM   760  C CA    . THR A 1 96  ? 26.701  -19.287 18.224 1.00 66.45  ? 98   THR A CA    1 ? 
ATOM   761  C C     . THR A 1 96  ? 26.861  -19.784 19.661 1.00 73.88  ? 98   THR A C     1 ? 
ATOM   762  O O     . THR A 1 96  ? 25.994  -19.477 20.534 1.00 74.63  ? 98   THR A O     1 ? 
ATOM   763  C CB    . THR A 1 96  ? 27.603  -18.085 17.986 1.00 60.75  ? 98   THR A CB    1 ? 
ATOM   764  O OG1   . THR A 1 96  ? 27.329  -17.134 19.014 1.00 61.60  ? 98   THR A OG1   1 ? 
ATOM   765  C CG2   . THR A 1 96  ? 27.388  -17.521 16.606 1.00 65.31  ? 98   THR A CG2   1 ? 
ATOM   766  N N     . ALA A 1 97  ? 27.965  -20.473 19.912 1.00 64.35  ? 99   ALA A N     1 ? 
ATOM   767  C CA    . ALA A 1 97  ? 28.270  -21.010 21.250 1.00 59.65  ? 99   ALA A CA    1 ? 
ATOM   768  C C     . ALA A 1 97  ? 28.307  -19.860 22.252 1.00 58.34  ? 99   ALA A C     1 ? 
ATOM   769  O O     . ALA A 1 97  ? 27.752  -20.019 23.351 1.00 62.91  ? 99   ALA A O     1 ? 
ATOM   770  C CB    . ALA A 1 97  ? 29.562  -21.800 21.222 1.00 57.20  ? 99   ALA A CB    1 ? 
ATOM   771  N N     . GLU A 1 98  ? 28.944  -18.749 21.892 1.00 64.81  ? 100  GLU A N     1 ? 
ATOM   772  C CA    . GLU A 1 98  ? 29.029  -17.584 22.795 1.00 63.96  ? 100  GLU A CA    1 ? 
ATOM   773  C C     . GLU A 1 98  ? 27.611  -17.086 23.072 1.00 62.66  ? 100  GLU A C     1 ? 
ATOM   774  O O     . GLU A 1 98  ? 27.280  -16.816 24.229 1.00 70.09  ? 100  GLU A O     1 ? 
ATOM   775  C CB    . GLU A 1 98  ? 29.903  -16.506 22.169 1.00 74.17  ? 100  GLU A CB    1 ? 
ATOM   776  C CG    . GLU A 1 98  ? 30.182  -15.344 23.106 1.00 74.23  ? 100  GLU A CG    1 ? 
ATOM   777  C CD    . GLU A 1 98  ? 30.661  -14.102 22.370 1.00 86.29  ? 100  GLU A CD    1 ? 
ATOM   778  O OE1   . GLU A 1 98  ? 30.602  -14.096 21.098 1.00 85.11  ? 100  GLU A OE1   1 ? 
ATOM   779  O OE2   . GLU A 1 98  ? 31.088  -13.136 23.055 1.00 84.23  ? 100  GLU A OE2   1 ? 
ATOM   780  N N     . ARG A 1 99  ? 26.788  -16.969 22.040 1.00 68.22  ? 101  ARG A N     1 ? 
ATOM   781  C CA    . ARG A 1 99  ? 25.397  -16.477 22.208 1.00 64.44  ? 101  ARG A CA    1 ? 
ATOM   782  C C     . ARG A 1 99  ? 24.611  -17.429 23.108 1.00 64.86  ? 101  ARG A C     1 ? 
ATOM   783  O O     . ARG A 1 99  ? 23.891  -16.947 24.014 1.00 64.53  ? 101  ARG A O     1 ? 
ATOM   784  C CB    . ARG A 1 99  ? 24.724  -16.342 20.847 1.00 64.18  ? 101  ARG A CB    1 ? 
ATOM   785  C CG    . ARG A 1 99  ? 23.294  -15.842 20.915 1.00 59.56  ? 101  ARG A CG    1 ? 
ATOM   786  C CD    . ARG A 1 99  ? 23.239  -14.354 21.204 1.00 63.77  ? 101  ARG A CD    1 ? 
ATOM   787  N NE    . ARG A 1 99  ? 21.894  -13.918 21.541 1.00 69.91  ? 101  ARG A NE    1 ? 
ATOM   788  C CZ    . ARG A 1 99  ? 21.492  -12.652 21.622 1.00 68.84  ? 101  ARG A CZ    1 ? 
ATOM   789  N NH1   . ARG A 1 99  ? 22.334  -11.661 21.389 1.00 70.37  ? 101  ARG A NH1   1 ? 
ATOM   790  N NH2   . ARG A 1 99  ? 20.243  -12.380 21.945 1.00 70.09  ? 101  ARG A NH2   1 ? 
ATOM   791  N N     . THR A 1 100 ? 24.766  -18.731 22.890 1.00 61.41  ? 102  THR A N     1 ? 
ATOM   792  C CA    . THR A 1 100 ? 24.070  -19.739 23.718 1.00 62.29  ? 102  THR A CA    1 ? 
ATOM   793  C C     . THR A 1 100 ? 24.497  -19.590 25.183 1.00 60.61  ? 102  THR A C     1 ? 
ATOM   794  O O     . THR A 1 100 ? 23.627  -19.566 26.040 1.00 59.38  ? 102  THR A O     1 ? 
ATOM   795  C CB    . THR A 1 100 ? 24.324  -21.157 23.201 1.00 64.09  ? 102  THR A CB    1 ? 
ATOM   796  O OG1   . THR A 1 100 ? 23.751  -21.381 21.911 1.00 62.32  ? 102  THR A OG1   1 ? 
ATOM   797  C CG2   . THR A 1 100 ? 23.714  -22.193 24.117 1.00 63.28  ? 102  THR A CG2   1 ? 
ATOM   798  N N     . ALA A 1 101 ? 25.799  -19.468 25.442 1.00 61.69  ? 103  ALA A N     1 ? 
ATOM   799  C CA    . ALA A 1 101 ? 26.358  -19.431 26.811 1.00 59.53  ? 103  ALA A CA    1 ? 
ATOM   800  C C     . ALA A 1 101 ? 25.929  -18.163 27.526 1.00 59.02  ? 103  ALA A C     1 ? 
ATOM   801  O O     . ALA A 1 101 ? 25.647  -18.215 28.748 1.00 65.97  ? 103  ALA A O     1 ? 
ATOM   802  C CB    . ALA A 1 101 ? 27.867  -19.517 26.772 1.00 60.65  ? 103  ALA A CB    1 ? 
ATOM   803  N N     . LEU A 1 102 ? 25.903  -17.051 26.796 1.00 64.48  ? 104  LEU A N     1 ? 
ATOM   804  C CA    . LEU A 1 102 ? 25.461  -15.747 27.373 1.00 66.72  ? 104  LEU A CA    1 ? 
ATOM   805  C C     . LEU A 1 102 ? 23.947  -15.759 27.639 1.00 62.63  ? 104  LEU A C     1 ? 
ATOM   806  O O     . LEU A 1 102 ? 23.507  -15.346 28.733 1.00 58.78  ? 104  LEU A O     1 ? 
ATOM   807  C CB    . LEU A 1 102 ? 25.869  -14.632 26.411 1.00 64.46  ? 104  LEU A CB    1 ? 
ATOM   808  C CG    . LEU A 1 102 ? 27.382  -14.359 26.343 1.00 62.69  ? 104  LEU A CG    1 ? 
ATOM   809  C CD1   . LEU A 1 102 ? 27.703  -13.310 25.294 1.00 60.34  ? 104  LEU A CD1   1 ? 
ATOM   810  C CD2   . LEU A 1 102 ? 27.907  -13.923 27.700 1.00 57.38  ? 104  LEU A CD2   1 ? 
ATOM   811  N N     . GLU A 1 103 ? 23.156  -16.250 26.693 1.00 63.97  ? 105  GLU A N     1 ? 
ATOM   812  C CA    . GLU A 1 103 ? 21.684  -16.339 26.915 1.00 68.64  ? 105  GLU A CA    1 ? 
ATOM   813  C C     . GLU A 1 103 ? 21.378  -17.228 28.133 1.00 65.90  ? 105  GLU A C     1 ? 
ATOM   814  O O     . GLU A 1 103 ? 20.551  -16.832 28.974 1.00 63.26  ? 105  GLU A O     1 ? 
ATOM   815  C CB    . GLU A 1 103 ? 20.970  -16.885 25.684 1.00 59.24  ? 105  GLU A CB    1 ? 
ATOM   816  C CG    . GLU A 1 103 ? 20.647  -15.823 24.660 1.00 67.07  ? 105  GLU A CG    1 ? 
ATOM   817  C CD    . GLU A 1 103 ? 19.836  -16.337 23.478 1.00 67.91  ? 105  GLU A CD    1 ? 
ATOM   818  O OE1   . GLU A 1 103 ? 19.267  -17.463 23.557 1.00 67.77  ? 105  GLU A OE1   1 ? 
ATOM   819  O OE2   . GLU A 1 103 ? 19.796  -15.631 22.479 1.00 64.46  ? 105  GLU A OE2   1 ? 
ATOM   820  N N     . ASN A 1 104 ? 22.022  -18.384 28.244 1.00 66.69  ? 106  ASN A N     1 ? 
ATOM   821  C CA    . ASN A 1 104 ? 21.737  -19.322 29.366 1.00 71.55  ? 106  ASN A CA    1 ? 
ATOM   822  C C     . ASN A 1 104 ? 22.185  -18.738 30.712 1.00 60.76  ? 106  ASN A C     1 ? 
ATOM   823  O O     . ASN A 1 104 ? 21.421  -18.826 31.676 1.00 65.77  ? 106  ASN A O     1 ? 
ATOM   824  C CB    . ASN A 1 104 ? 22.375  -20.678 29.112 1.00 74.22  ? 106  ASN A CB    1 ? 
ATOM   825  C CG    . ASN A 1 104 ? 21.757  -21.362 27.906 1.00 80.73  ? 106  ASN A CG    1 ? 
ATOM   826  O OD1   . ASN A 1 104 ? 20.963  -20.763 27.137 1.00 78.14  ? 106  ASN A OD1   1 ? 
ATOM   827  N ND2   . ASN A 1 104 ? 22.103  -22.631 27.746 1.00 84.04  ? 106  ASN A ND2   1 ? 
ATOM   828  N N     . ALA A 1 105 ? 23.358  -18.121 30.756 1.00 58.42  ? 107  ALA A N     1 ? 
ATOM   829  C CA    . ALA A 1 105 ? 23.831  -17.419 31.963 1.00 59.75  ? 107  ALA A CA    1 ? 
ATOM   830  C C     . ALA A 1 105 ? 22.867  -16.295 32.329 1.00 60.64  ? 107  ALA A C     1 ? 
ATOM   831  O O     . ALA A 1 105 ? 22.496  -16.207 33.511 1.00 66.50  ? 107  ALA A O     1 ? 
ATOM   832  C CB    . ALA A 1 105 ? 25.236  -16.915 31.758 1.00 56.70  ? 107  ALA A CB    1 ? 
ATOM   833  N N     . GLY A 1 106 ? 22.474  -15.481 31.349 1.00 63.08  ? 108  GLY A N     1 ? 
ATOM   834  C CA    . GLY A 1 106 ? 21.558  -14.350 31.605 1.00 58.89  ? 108  GLY A CA    1 ? 
ATOM   835  C C     . GLY A 1 106 ? 20.217  -14.827 32.090 1.00 56.17  ? 108  GLY A C     1 ? 
ATOM   836  O O     . GLY A 1 106 ? 19.695  -14.230 33.047 1.00 65.99  ? 108  GLY A O     1 ? 
ATOM   837  N N     . THR A 1 107 ? 19.695  -15.885 31.477 1.00 62.16  ? 109  THR A N     1 ? 
ATOM   838  C CA    . THR A 1 107 ? 18.397  -16.471 31.894 1.00 61.55  ? 109  THR A CA    1 ? 
ATOM   839  C C     . THR A 1 107 ? 18.494  -16.969 33.333 1.00 60.43  ? 109  THR A C     1 ? 
ATOM   840  O O     . THR A 1 107 ? 17.542  -16.768 34.079 1.00 64.44  ? 109  THR A O     1 ? 
ATOM   841  C CB    . THR A 1 107 ? 17.955  -17.574 30.940 1.00 64.43  ? 109  THR A CB    1 ? 
ATOM   842  O OG1   . THR A 1 107 ? 17.935  -17.009 29.629 1.00 73.75  ? 109  THR A OG1   1 ? 
ATOM   843  C CG2   . THR A 1 107 ? 16.591  -18.106 31.306 1.00 60.92  ? 109  THR A CG2   1 ? 
ATOM   844  N N     . ALA A 1 108 ? 19.610  -17.577 33.714 1.00 68.89  ? 110  ALA A N     1 ? 
ATOM   845  C CA    . ALA A 1 108 ? 19.831  -18.012 35.113 1.00 65.37  ? 110  ALA A CA    1 ? 
ATOM   846  C C     . ALA A 1 108 ? 19.813  -16.795 36.040 1.00 61.57  ? 110  ALA A C     1 ? 
ATOM   847  O O     . ALA A 1 108 ? 19.188  -16.852 37.096 1.00 64.56  ? 110  ALA A O     1 ? 
ATOM   848  C CB    . ALA A 1 108 ? 21.124  -18.767 35.238 1.00 66.34  ? 110  ALA A CB    1 ? 
ATOM   849  N N     . MET A 1 109 ? 20.457  -15.703 35.658 1.00 64.97  ? 111  MET A N     1 ? 
ATOM   850  C CA    . MET A 1 109 ? 20.510  -14.496 36.525 1.00 62.24  ? 111  MET A CA    1 ? 
ATOM   851  C C     . MET A 1 109 ? 19.161  -13.753 36.551 1.00 67.58  ? 111  MET A C     1 ? 
ATOM   852  O O     . MET A 1 109 ? 18.903  -12.993 37.532 1.00 62.57  ? 111  MET A O     1 ? 
ATOM   853  C CB    . MET A 1 109 ? 21.585  -13.529 36.047 1.00 60.47  ? 111  MET A CB    1 ? 
ATOM   854  C CG    . MET A 1 109 ? 22.965  -14.131 36.030 1.00 62.38  ? 111  MET A CG    1 ? 
ATOM   855  S SD    . MET A 1 109 ? 24.079  -13.209 34.972 1.00 64.14  ? 111  MET A SD    1 ? 
ATOM   856  C CE    . MET A 1 109 ? 24.440  -11.839 36.070 1.00 57.92  ? 111  MET A CE    1 ? 
ATOM   857  N N     . LEU A 1 110 ? 18.315  -13.933 35.537 1.00 64.74  ? 112  LEU A N     1 ? 
ATOM   858  C CA    . LEU A 1 110 ? 16.972  -13.298 35.536 1.00 60.34  ? 112  LEU A CA    1 ? 
ATOM   859  C C     . LEU A 1 110 ? 16.134  -13.818 36.712 1.00 64.14  ? 112  LEU A C     1 ? 
ATOM   860  O O     . LEU A 1 110 ? 15.207  -13.105 37.147 1.00 57.60  ? 112  LEU A O     1 ? 
ATOM   861  C CB    . LEU A 1 110 ? 16.270  -13.584 34.209 1.00 64.66  ? 112  LEU A CB    1 ? 
ATOM   862  C CG    . LEU A 1 110 ? 16.724  -12.717 33.040 1.00 64.43  ? 112  LEU A CG    1 ? 
ATOM   863  C CD1   . LEU A 1 110 ? 16.240  -13.309 31.725 1.00 61.15  ? 112  LEU A CD1   1 ? 
ATOM   864  C CD2   . LEU A 1 110 ? 16.228  -11.283 33.213 1.00 61.13  ? 112  LEU A CD2   1 ? 
ATOM   865  N N     . CYS A 1 111 ? 16.451  -14.994 37.249 1.00 63.73  ? 113  CYS A N     1 ? 
ATOM   866  C CA    . CYS A 1 111 ? 15.752  -15.502 38.462 1.00 67.66  ? 113  CYS A CA    1 ? 
ATOM   867  C C     . CYS A 1 111 ? 16.109  -14.654 39.707 1.00 60.15  ? 113  CYS A C     1 ? 
ATOM   868  O O     . CYS A 1 111 ? 15.425  -14.739 40.734 1.00 55.79  ? 113  CYS A O     1 ? 
ATOM   869  C CB    . CYS A 1 111 ? 16.092  -16.963 38.725 1.00 63.44  ? 113  CYS A CB    1 ? 
ATOM   870  S SG    . CYS A 1 111 ? 15.760  -18.098 37.364 1.00 68.98  ? 113  CYS A SG    1 ? 
ATOM   871  N N     . LYS A 1 112 ? 17.146  -13.831 39.618 1.00 68.20  ? 114  LYS A N     1 ? 
ATOM   872  C CA    . LYS A 1 112 ? 17.584  -12.993 40.765 1.00 75.34  ? 114  LYS A CA    1 ? 
ATOM   873  C C     . LYS A 1 112 ? 17.634  -11.521 40.360 1.00 74.02  ? 114  LYS A C     1 ? 
ATOM   874  O O     . LYS A 1 112 ? 18.523  -10.796 40.856 1.00 69.42  ? 114  LYS A O     1 ? 
ATOM   875  C CB    . LYS A 1 112 ? 18.953  -13.449 41.259 1.00 74.11  ? 114  LYS A CB    1 ? 
ATOM   876  C CG    . LYS A 1 112 ? 18.982  -14.866 41.802 1.00 76.63  ? 114  LYS A CG    1 ? 
ATOM   877  C CD    . LYS A 1 112 ? 20.390  -15.387 41.958 1.00 80.39  ? 114  LYS A CD    1 ? 
ATOM   878  C CE    . LYS A 1 112 ? 20.456  -16.619 42.835 1.00 83.76  ? 114  LYS A CE    1 ? 
ATOM   879  N NZ    . LYS A 1 112 ? 20.069  -16.288 44.231 1.00 89.50  ? 114  LYS A NZ    1 ? 
ATOM   880  N N     . THR A 1 113 ? 16.666  -11.078 39.555 1.00 66.85  ? 115  THR A N     1 ? 
ATOM   881  C CA    . THR A 1 113 ? 16.668  -9.709  39.018 1.00 56.11  ? 115  THR A CA    1 ? 
ATOM   882  C C     . THR A 1 113 ? 15.404  -8.967  39.431 1.00 51.43  ? 115  THR A C     1 ? 
ATOM   883  O O     . THR A 1 113 ? 14.294  -9.509  39.331 1.00 52.98  ? 115  THR A O     1 ? 
ATOM   884  C CB    . THR A 1 113 ? 16.857  -9.738  37.509 1.00 58.27  ? 115  THR A CB    1 ? 
ATOM   885  O OG1   . THR A 1 113 ? 18.081  -10.444 37.283 1.00 60.58  ? 115  THR A OG1   1 ? 
ATOM   886  C CG2   . THR A 1 113 ? 16.961  -8.346  36.930 1.00 62.25  ? 115  THR A CG2   1 ? 
ATOM   887  N N     . VAL A 1 114 ? 15.598  -7.740  39.874 1.00 49.23  ? 116  VAL A N     1 ? 
ATOM   888  C CA    . VAL A 1 114 ? 14.504  -6.762  40.085 1.00 53.68  ? 116  VAL A CA    1 ? 
ATOM   889  C C     . VAL A 1 114 ? 14.320  -5.972  38.795 1.00 57.35  ? 116  VAL A C     1 ? 
ATOM   890  O O     . VAL A 1 114 ? 15.319  -5.661  38.124 1.00 59.22  ? 116  VAL A O     1 ? 
ATOM   891  C CB    . VAL A 1 114 ? 14.839  -5.827  41.245 1.00 55.42  ? 116  VAL A CB    1 ? 
ATOM   892  C CG1   . VAL A 1 114 ? 13.771  -4.747  41.398 1.00 61.45  ? 116  VAL A CG1   1 ? 
ATOM   893  C CG2   . VAL A 1 114 ? 15.031  -6.604  42.540 1.00 53.96  ? 116  VAL A CG2   1 ? 
ATOM   894  N N     . PHE A 1 115 ? 13.071  -5.706  38.450 1.00 56.83  ? 117  PHE A N     1 ? 
ATOM   895  C CA    . PHE A 1 115 ? 12.716  -4.976  37.214 1.00 59.62  ? 117  PHE A CA    1 ? 
ATOM   896  C C     . PHE A 1 115 ? 12.040  -3.672  37.600 1.00 55.78  ? 117  PHE A C     1 ? 
ATOM   897  O O     . PHE A 1 115 ? 11.168  -3.678  38.497 1.00 56.38  ? 117  PHE A O     1 ? 
ATOM   898  C CB    . PHE A 1 115 ? 11.819  -5.805  36.306 1.00 60.99  ? 117  PHE A CB    1 ? 
ATOM   899  C CG    . PHE A 1 115 ? 12.427  -7.109  35.884 1.00 57.54  ? 117  PHE A CG    1 ? 
ATOM   900  C CD1   . PHE A 1 115 ? 12.253  -8.244  36.656 1.00 56.43  ? 117  PHE A CD1   1 ? 
ATOM   901  C CD2   . PHE A 1 115 ? 13.154  -7.202  34.708 1.00 57.39  ? 117  PHE A CD2   1 ? 
ATOM   902  C CE1   . PHE A 1 115 ? 12.811  -9.458  36.275 1.00 52.40  ? 117  PHE A CE1   1 ? 
ATOM   903  C CE2   . PHE A 1 115 ? 13.706  -8.414  34.320 1.00 57.09  ? 117  PHE A CE2   1 ? 
ATOM   904  C CZ    . PHE A 1 115 ? 13.549  -9.535  35.115 1.00 54.37  ? 117  PHE A CZ    1 ? 
ATOM   905  N N     . VAL A 1 116 ? 12.461  -2.599  36.919 1.00 55.29  ? 118  VAL A N     1 ? 
ATOM   906  C CA    . VAL A 1 116 ? 11.875  -1.236  37.091 1.00 54.88  ? 118  VAL A CA    1 ? 
ATOM   907  C C     . VAL A 1 116 ? 11.497  -0.690  35.720 1.00 49.91  ? 118  VAL A C     1 ? 
ATOM   908  O O     . VAL A 1 116 ? 12.308  -0.744  34.814 1.00 54.28  ? 118  VAL A O     1 ? 
ATOM   909  C CB    . VAL A 1 116 ? 12.842  -0.278  37.792 1.00 50.18  ? 118  VAL A CB    1 ? 
ATOM   910  C CG1   . VAL A 1 116 ? 12.136  1.008   38.169 1.00 50.43  ? 118  VAL A CG1   1 ? 
ATOM   911  C CG2   . VAL A 1 116 ? 13.466  -0.926  39.008 1.00 52.13  ? 118  VAL A CG2   1 ? 
ATOM   912  N N     . LEU A 1 117 ? 10.277  -0.196  35.617 1.00 55.89  ? 119  LEU A N     1 ? 
ATOM   913  C CA    . LEU A 1 117 ? 9.729   0.350   34.355 1.00 54.30  ? 119  LEU A CA    1 ? 
ATOM   914  C C     . LEU A 1 117 ? 9.351   1.815   34.595 1.00 55.00  ? 119  LEU A C     1 ? 
ATOM   915  O O     . LEU A 1 117 ? 8.521   2.095   35.484 1.00 48.38  ? 119  LEU A O     1 ? 
ATOM   916  C CB    . LEU A 1 117 ? 8.527   -0.480  33.903 1.00 48.68  ? 119  LEU A CB    1 ? 
ATOM   917  C CG    . LEU A 1 117 ? 7.657   0.157   32.805 1.00 49.56  ? 119  LEU A CG    1 ? 
ATOM   918  C CD1   . LEU A 1 117 ? 8.465   0.399   31.529 1.00 49.19  ? 119  LEU A CD1   1 ? 
ATOM   919  C CD2   . LEU A 1 117 ? 6.480   -0.738  32.488 1.00 46.83  ? 119  LEU A CD2   1 ? 
ATOM   920  N N     . VAL A 1 118 ? 9.937   2.704   33.809 1.00 53.85  ? 120  VAL A N     1 ? 
ATOM   921  C CA    . VAL A 1 118 ? 9.598   4.151   33.870 1.00 52.81  ? 120  VAL A CA    1 ? 
ATOM   922  C C     . VAL A 1 118 ? 8.465   4.410   32.884 1.00 53.14  ? 120  VAL A C     1 ? 
ATOM   923  O O     . VAL A 1 118 ? 8.698   4.305   31.679 1.00 54.44  ? 120  VAL A O     1 ? 
ATOM   924  C CB    . VAL A 1 118 ? 10.844  5.025   33.604 1.00 61.29  ? 120  VAL A CB    1 ? 
ATOM   925  C CG1   . VAL A 1 118 ? 11.766  4.999   34.819 1.00 61.02  ? 120  VAL A CG1   1 ? 
ATOM   926  C CG2   . VAL A 1 118 ? 11.628  4.610   32.369 1.00 58.66  ? 120  VAL A CG2   1 ? 
ATOM   927  N N     . ALA A 1 119 ? 7.277   4.695   33.421 1.00 59.85  ? 121  ALA A N     1 ? 
ATOM   928  C CA    . ALA A 1 119 ? 6.040   4.896   32.633 1.00 57.06  ? 121  ALA A CA    1 ? 
ATOM   929  C C     . ALA A 1 119 ? 5.294   6.105   33.186 1.00 51.22  ? 121  ALA A C     1 ? 
ATOM   930  O O     . ALA A 1 119 ? 4.101   6.036   33.406 1.00 58.69  ? 121  ALA A O     1 ? 
ATOM   931  C CB    . ALA A 1 119 ? 5.206   3.654   32.638 1.00 51.06  ? 121  ALA A CB    1 ? 
ATOM   932  N N     . GLY A 1 120 ? 6.010   7.214   33.347 1.00 56.75  ? 122  GLY A N     1 ? 
ATOM   933  C CA    . GLY A 1 120 ? 5.402   8.476   33.803 1.00 56.34  ? 122  GLY A CA    1 ? 
ATOM   934  C C     . GLY A 1 120 ? 5.154   9.430   32.652 1.00 56.82  ? 122  GLY A C     1 ? 
ATOM   935  O O     . GLY A 1 120 ? 4.487   10.443  32.883 1.00 62.93  ? 122  GLY A O     1 ? 
ATOM   936  N N     . GLY A 1 121 ? 5.608   9.095   31.442 1.00 62.25  ? 123  GLY A N     1 ? 
ATOM   937  C CA    . GLY A 1 121 ? 5.624   10.044  30.321 1.00 59.03  ? 123  GLY A CA    1 ? 
ATOM   938  C C     . GLY A 1 121 ? 4.365   9.993   29.500 1.00 61.17  ? 123  GLY A C     1 ? 
ATOM   939  O O     . GLY A 1 121 ? 3.779   8.903   29.375 1.00 66.47  ? 123  GLY A O     1 ? 
ATOM   940  N N     . LEU A 1 122 ? 3.983   11.136  28.926 1.00 75.95  ? 124  LEU A N     1 ? 
ATOM   941  C CA    . LEU A 1 122 ? 2.851   11.243  27.969 1.00 89.98  ? 124  LEU A CA    1 ? 
ATOM   942  C C     . LEU A 1 122 ? 3.298   10.820  26.572 1.00 87.64  ? 124  LEU A C     1 ? 
ATOM   943  O O     . LEU A 1 122 ? 4.503   10.981  26.245 1.00 87.37  ? 124  LEU A O     1 ? 
ATOM   944  C CB    . LEU A 1 122 ? 2.358   12.686  27.880 1.00 95.11  ? 124  LEU A CB    1 ? 
ATOM   945  C CG    . LEU A 1 122 ? 2.067   13.387  29.200 1.00 97.95  ? 124  LEU A CG    1 ? 
ATOM   946  C CD1   . LEU A 1 122 ? 2.311   14.893  29.068 1.00 97.13  ? 124  LEU A CD1   1 ? 
ATOM   947  C CD2   . LEU A 1 122 ? 0.631   13.110  29.597 1.00 100.26 ? 124  LEU A CD2   1 ? 
ATOM   948  N N     . GLY A 1 123 ? 2.331   10.374  25.764 1.00 102.96 ? 125  GLY A N     1 ? 
ATOM   949  C CA    . GLY A 1 123 ? 2.563   10.043  24.346 1.00 111.75 ? 125  GLY A CA    1 ? 
ATOM   950  C C     . GLY A 1 123 ? 1.642   10.828  23.428 1.00 113.39 ? 125  GLY A C     1 ? 
ATOM   951  O O     . GLY A 1 123 ? 1.133   10.224  22.453 1.00 108.54 ? 125  GLY A O     1 ? 
ATOM   952  N N     . GLU A 1 124 ? 1.399   12.107  23.739 1.00 113.59 ? 126  GLU A N     1 ? 
ATOM   953  C CA    . GLU A 1 124 ? 0.544   12.968  22.877 1.00 113.48 ? 126  GLU A CA    1 ? 
ATOM   954  C C     . GLU A 1 124 ? 1.298   13.307  21.589 1.00 100.50 ? 126  GLU A C     1 ? 
ATOM   955  O O     . GLU A 1 124 ? 0.620   13.523  20.566 1.00 92.38  ? 126  GLU A O     1 ? 
ATOM   956  C CB    . GLU A 1 124 ? 0.114   14.237  23.610 1.00 111.49 ? 126  GLU A CB    1 ? 
ATOM   957  C CG    . GLU A 1 124 ? -1.067  14.921  22.940 1.00 116.69 ? 126  GLU A CG    1 ? 
ATOM   958  C CD    . GLU A 1 124 ? -2.373  14.142  23.034 1.00 119.94 ? 126  GLU A CD    1 ? 
ATOM   959  O OE1   . GLU A 1 124 ? -2.530  13.370  24.019 1.00 112.50 ? 126  GLU A OE1   1 ? 
ATOM   960  O OE2   . GLU A 1 124 ? -3.237  14.310  22.136 1.00 118.59 ? 126  GLU A OE2   1 ? 
ATOM   961  N N     . ARG A 1 125 ? 2.634   13.326  21.644 1.00 91.41  ? 127  ARG A N     1 ? 
ATOM   962  C CA    . ARG A 1 125 ? 3.474   13.510  20.434 1.00 90.22  ? 127  ARG A CA    1 ? 
ATOM   963  C C     . ARG A 1 125 ? 3.147   12.485  19.347 1.00 90.48  ? 127  ARG A C     1 ? 
ATOM   964  O O     . ARG A 1 125 ? 3.357   12.825  18.162 1.00 96.23  ? 127  ARG A O     1 ? 
ATOM   965  C CB    . ARG A 1 125 ? 4.955   13.401  20.772 1.00 88.30  ? 127  ARG A CB    1 ? 
ATOM   966  C CG    . ARG A 1 125 ? 5.421   14.448  21.768 1.00 97.24  ? 127  ARG A CG    1 ? 
ATOM   967  C CD    . ARG A 1 125 ? 6.916   14.658  21.687 1.00 101.85 ? 127  ARG A CD    1 ? 
ATOM   968  N NE    . ARG A 1 125 ? 7.606   13.573  20.989 1.00 104.98 ? 127  ARG A NE    1 ? 
ATOM   969  C CZ    . ARG A 1 125 ? 8.200   13.685  19.795 1.00 106.32 ? 127  ARG A CZ    1 ? 
ATOM   970  N NH1   . ARG A 1 125 ? 8.188   14.841  19.134 1.00 105.05 ? 127  ARG A NH1   1 ? 
ATOM   971  N NH2   . ARG A 1 125 ? 8.804   12.635  19.260 1.00 96.43  ? 127  ARG A NH2   1 ? 
ATOM   972  N N     . LEU A 1 126 ? 2.690   11.287  19.724 1.00 74.90  ? 128  LEU A N     1 ? 
ATOM   973  C CA    . LEU A 1 126 ? 2.358   10.213  18.761 1.00 69.52  ? 128  LEU A CA    1 ? 
ATOM   974  C C     . LEU A 1 126 ? 1.042   10.519  18.062 1.00 67.32  ? 128  LEU A C     1 ? 
ATOM   975  O O     . LEU A 1 126 ? 0.850   10.008  16.955 1.00 76.35  ? 128  LEU A O     1 ? 
ATOM   976  C CB    . LEU A 1 126 ? 2.216   8.877   19.492 1.00 78.99  ? 128  LEU A CB    1 ? 
ATOM   977  C CG    . LEU A 1 126 ? 3.472   8.257   20.087 1.00 77.65  ? 128  LEU A CG    1 ? 
ATOM   978  C CD1   . LEU A 1 126 ? 3.331   6.746   20.114 1.00 85.66  ? 128  LEU A CD1   1 ? 
ATOM   979  C CD2   . LEU A 1 126 ? 4.699   8.646   19.298 1.00 77.50  ? 128  LEU A CD2   1 ? 
ATOM   980  N N     . GLY A 1 127 ? 0.159   11.275  18.708 1.00 68.90  ? 129  GLY A N     1 ? 
ATOM   981  C CA    . GLY A 1 127 ? -1.259  11.319  18.311 1.00 73.63  ? 129  GLY A CA    1 ? 
ATOM   982  C C     . GLY A 1 127 ? -2.062  10.289  19.078 1.00 76.15  ? 129  GLY A C     1 ? 
ATOM   983  O O     . GLY A 1 127 ? -3.166  9.876   18.590 1.00 77.78  ? 129  GLY A O     1 ? 
ATOM   984  N N     . TYR A 1 128 ? -1.526  9.856   20.222 1.00 64.24  ? 130  TYR A N     1 ? 
ATOM   985  C CA    . TYR A 1 128 ? -2.189  8.845   21.084 1.00 67.62  ? 130  TYR A CA    1 ? 
ATOM   986  C C     . TYR A 1 128 ? -2.597  9.515   22.394 1.00 62.96  ? 130  TYR A C     1 ? 
ATOM   987  O O     . TYR A 1 128 ? -1.749  10.027  23.124 1.00 54.57  ? 130  TYR A O     1 ? 
ATOM   988  C CB    . TYR A 1 128 ? -1.282  7.641   21.342 1.00 58.81  ? 130  TYR A CB    1 ? 
ATOM   989  C CG    . TYR A 1 128 ? -1.962  6.472   22.004 1.00 56.73  ? 130  TYR A CG    1 ? 
ATOM   990  C CD1   . TYR A 1 128 ? -3.035  5.822   21.411 1.00 61.59  ? 130  TYR A CD1   1 ? 
ATOM   991  C CD2   . TYR A 1 128 ? -1.517  5.995   23.222 1.00 63.84  ? 130  TYR A CD2   1 ? 
ATOM   992  C CE1   . TYR A 1 128 ? -3.665  4.744   22.016 1.00 58.43  ? 130  TYR A CE1   1 ? 
ATOM   993  C CE2   . TYR A 1 128 ? -2.110  4.903   23.833 1.00 62.95  ? 130  TYR A CE2   1 ? 
ATOM   994  C CZ    . TYR A 1 128 ? -3.196  4.274   23.232 1.00 68.31  ? 130  TYR A CZ    1 ? 
ATOM   995  O OH    . TYR A 1 128 ? -3.796  3.205   23.848 1.00 62.43  ? 130  TYR A OH    1 ? 
ATOM   996  N N     . SER A 1 129 ? -3.885  9.495   22.681 1.00 65.38  ? 131  SER A N     1 ? 
ATOM   997  C CA    . SER A 1 129 ? -4.435  10.257  23.825 1.00 60.91  ? 131  SER A CA    1 ? 
ATOM   998  C C     . SER A 1 129 ? -4.335  9.462   25.118 1.00 63.55  ? 131  SER A C     1 ? 
ATOM   999  O O     . SER A 1 129 ? -4.590  10.044  26.165 1.00 71.65  ? 131  SER A O     1 ? 
ATOM   1000 C CB    . SER A 1 129 ? -5.840  10.675  23.561 1.00 58.89  ? 131  SER A CB    1 ? 
ATOM   1001 O OG    . SER A 1 129 ? -6.655  9.542   23.342 1.00 73.37  ? 131  SER A OG    1 ? 
ATOM   1002 N N     . SER A 1 130 ? -3.969  8.186   25.043 1.00 67.74  ? 132  SER A N     1 ? 
ATOM   1003 C CA    . SER A 1 130 ? -3.880  7.312   26.239 1.00 64.48  ? 132  SER A CA    1 ? 
ATOM   1004 C C     . SER A 1 130 ? -2.423  7.079   26.621 1.00 58.96  ? 132  SER A C     1 ? 
ATOM   1005 O O     . SER A 1 130 ? -1.528  7.678   26.005 1.00 67.23  ? 132  SER A O     1 ? 
ATOM   1006 C CB    . SER A 1 130 ? -4.620  6.042   26.031 1.00 65.95  ? 132  SER A CB    1 ? 
ATOM   1007 O OG    . SER A 1 130 ? -5.055  5.549   27.287 1.00 80.88  ? 132  SER A OG    1 ? 
ATOM   1008 N N     . ILE A 1 131 ? -2.203  6.285   27.655 1.00 60.11  ? 133  ILE A N     1 ? 
ATOM   1009 C CA    . ILE A 1 131 ? -0.837  6.044   28.199 1.00 57.16  ? 133  ILE A CA    1 ? 
ATOM   1010 C C     . ILE A 1 131 ? -0.066  5.126   27.257 1.00 51.32  ? 133  ILE A C     1 ? 
ATOM   1011 O O     . ILE A 1 131 ? -0.647  4.252   26.631 1.00 57.00  ? 133  ILE A O     1 ? 
ATOM   1012 C CB    . ILE A 1 131 ? -0.907  5.461   29.616 1.00 54.23  ? 133  ILE A CB    1 ? 
ATOM   1013 C CG1   . ILE A 1 131 ? -1.588  4.095   29.617 1.00 59.24  ? 133  ILE A CG1   1 ? 
ATOM   1014 C CG2   . ILE A 1 131 ? -1.626  6.409   30.548 1.00 58.05  ? 133  ILE A CG2   1 ? 
ATOM   1015 C CD1   . ILE A 1 131 ? -1.519  3.397   30.960 1.00 59.00  ? 133  ILE A CD1   1 ? 
ATOM   1016 N N     . LYS A 1 132 ? 1.241   5.282   27.242 1.00 58.53  ? 134  LYS A N     1 ? 
ATOM   1017 C CA    . LYS A 1 132 ? 2.112   4.610   26.260 1.00 56.12  ? 134  LYS A CA    1 ? 
ATOM   1018 C C     . LYS A 1 132 ? 2.159   3.106   26.501 1.00 49.57  ? 134  LYS A C     1 ? 
ATOM   1019 O O     . LYS A 1 132 ? 2.254   2.373   25.510 1.00 49.70  ? 134  LYS A O     1 ? 
ATOM   1020 C CB    . LYS A 1 132 ? 3.498   5.237   26.296 1.00 54.81  ? 134  LYS A CB    1 ? 
ATOM   1021 C CG    . LYS A 1 132 ? 3.495   6.663   25.768 1.00 62.67  ? 134  LYS A CG    1 ? 
ATOM   1022 C CD    . LYS A 1 132 ? 4.864   7.233   25.545 1.00 66.28  ? 134  LYS A CD    1 ? 
ATOM   1023 C CE    . LYS A 1 132 ? 5.470   6.791   24.234 1.00 64.73  ? 134  LYS A CE    1 ? 
ATOM   1024 N NZ    . LYS A 1 132 ? 6.913   7.141   24.184 1.00 67.64  ? 134  LYS A NZ    1 ? 
ATOM   1025 N N     . VAL A 1 133 ? 2.083   2.673   27.759 1.00 48.86  ? 135  VAL A N     1 ? 
ATOM   1026 C CA    . VAL A 1 133 ? 2.155   1.217   28.078 1.00 48.29  ? 135  VAL A CA    1 ? 
ATOM   1027 C C     . VAL A 1 133 ? 0.842   0.551   27.664 1.00 43.84  ? 135  VAL A C     1 ? 
ATOM   1028 O O     . VAL A 1 133 ? 0.798   -0.688  27.658 1.00 43.47  ? 135  VAL A O     1 ? 
ATOM   1029 C CB    . VAL A 1 133 ? 2.496   0.944   29.554 1.00 46.97  ? 135  VAL A CB    1 ? 
ATOM   1030 C CG1   . VAL A 1 133 ? 3.898   1.440   29.892 1.00 46.45  ? 135  VAL A CG1   1 ? 
ATOM   1031 C CG2   . VAL A 1 133 ? 1.468   1.539   30.491 1.00 49.67  ? 135  VAL A CG2   1 ? 
ATOM   1032 N N     . SER A 1 134 ? -0.171  1.320   27.317 1.00 45.40  ? 136  SER A N     1 ? 
ATOM   1033 C CA    . SER A 1 134 ? -1.439  0.748   26.806 1.00 47.69  ? 136  SER A CA    1 ? 
ATOM   1034 C C     . SER A 1 134 ? -1.330  0.483   25.306 1.00 47.57  ? 136  SER A C     1 ? 
ATOM   1035 O O     . SER A 1 134 ? -2.186  -0.189  24.763 1.00 49.94  ? 136  SER A O     1 ? 
ATOM   1036 C CB    . SER A 1 134 ? -2.620  1.656   27.125 1.00 43.79  ? 136  SER A CB    1 ? 
ATOM   1037 O OG    . SER A 1 134 ? -2.587  2.889   26.427 1.00 48.27  ? 136  SER A OG    1 ? 
ATOM   1038 N N     . LEU A 1 135 ? -0.301  1.020   24.657 1.00 42.54  ? 137  LEU A N     1 ? 
ATOM   1039 C CA    . LEU A 1 135 ? -0.092  0.745   23.218 1.00 47.43  ? 137  LEU A CA    1 ? 
ATOM   1040 C C     . LEU A 1 135 ? 0.148   -0.751  23.046 1.00 53.38  ? 137  LEU A C     1 ? 
ATOM   1041 O O     . LEU A 1 135 ? 0.768   -1.375  23.902 1.00 52.02  ? 137  LEU A O     1 ? 
ATOM   1042 C CB    . LEU A 1 135 ? 1.094   1.513   22.655 1.00 43.23  ? 137  LEU A CB    1 ? 
ATOM   1043 C CG    . LEU A 1 135 ? 0.877   2.984   22.369 1.00 45.66  ? 137  LEU A CG    1 ? 
ATOM   1044 C CD1   . LEU A 1 135 ? 2.195   3.638   22.161 1.00 45.15  ? 137  LEU A CD1   1 ? 
ATOM   1045 C CD2   . LEU A 1 135 ? -0.010  3.189   21.173 1.00 56.23  ? 137  LEU A CD2   1 ? 
ATOM   1046 N N     . PRO A 1 136 ? -0.406  -1.357  21.973 1.00 47.75  ? 138  PRO A N     1 ? 
ATOM   1047 C CA    . PRO A 1 136 ? -0.093  -2.732  21.655 1.00 45.07  ? 138  PRO A CA    1 ? 
ATOM   1048 C C     . PRO A 1 136 ? 1.341   -2.805  21.104 1.00 48.94  ? 138  PRO A C     1 ? 
ATOM   1049 O O     . PRO A 1 136 ? 1.763   -1.960  20.344 1.00 48.61  ? 138  PRO A O     1 ? 
ATOM   1050 C CB    . PRO A 1 136 ? -1.139  -3.128  20.605 1.00 45.63  ? 138  PRO A CB    1 ? 
ATOM   1051 C CG    . PRO A 1 136 ? -1.486  -1.811  19.947 1.00 46.01  ? 138  PRO A CG    1 ? 
ATOM   1052 C CD    . PRO A 1 136 ? -1.383  -0.772  21.048 1.00 42.05  ? 138  PRO A CD    1 ? 
ATOM   1053 N N     . VAL A 1 137 ? 2.057   -3.840  21.512 1.00 51.81  ? 139  VAL A N     1 ? 
ATOM   1054 C CA    . VAL A 1 137 ? 3.352   -4.196  20.893 1.00 47.08  ? 139  VAL A CA    1 ? 
ATOM   1055 C C     . VAL A 1 137 ? 3.091   -4.614  19.438 1.00 50.39  ? 139  VAL A C     1 ? 
ATOM   1056 O O     . VAL A 1 137 ? 3.878   -4.235  18.552 1.00 48.42  ? 139  VAL A O     1 ? 
ATOM   1057 C CB    . VAL A 1 137 ? 4.052   -5.305  21.696 1.00 47.56  ? 139  VAL A CB    1 ? 
ATOM   1058 C CG1   . VAL A 1 137 ? 5.357   -5.698  21.017 1.00 50.97  ? 139  VAL A CG1   1 ? 
ATOM   1059 C CG2   . VAL A 1 137 ? 4.302   -4.887  23.135 1.00 46.42  ? 139  VAL A CG2   1 ? 
ATOM   1060 N N     . GLU A 1 138 ? 2.022   -5.362  19.202 1.00 54.53  ? 140  GLU A N     1 ? 
ATOM   1061 C CA    . GLU A 1 138 ? 1.584   -5.733  17.840 1.00 49.13  ? 140  GLU A CA    1 ? 
ATOM   1062 C C     . GLU A 1 138 ? 0.061   -5.837  17.876 1.00 48.15  ? 140  GLU A C     1 ? 
ATOM   1063 O O     . GLU A 1 138 ? -0.497  -6.101  18.976 1.00 50.17  ? 140  GLU A O     1 ? 
ATOM   1064 C CB    . GLU A 1 138 ? 2.230   -7.059  17.413 1.00 51.83  ? 140  GLU A CB    1 ? 
ATOM   1065 C CG    . GLU A 1 138 ? 1.365   -8.317  17.739 1.00 53.09  ? 140  GLU A CG    1 ? 
ATOM   1066 C CD    . GLU A 1 138 ? 1.583   -8.830  19.136 1.00 56.05  ? 140  GLU A CD    1 ? 
ATOM   1067 O OE1   . GLU A 1 138 ? 2.634   -8.516  19.707 1.00 88.32  ? 140  GLU A OE1   1 ? 
ATOM   1068 O OE2   . GLU A 1 138 ? 0.738   -9.494  19.651 1.00 62.88  ? 140  GLU A OE2   1 ? 
ATOM   1069 N N     . THR A 1 139 ? -0.564  -5.680  16.734 1.00 39.03  ? 141  THR A N     1 ? 
ATOM   1070 C CA    . THR A 1 139 ? -2.036  -5.710  16.603 1.00 39.56  ? 141  THR A CA    1 ? 
ATOM   1071 C C     . THR A 1 139 ? -2.562  -7.085  16.230 1.00 38.49  ? 141  THR A C     1 ? 
ATOM   1072 O O     . THR A 1 139 ? -3.761  -7.201  16.113 1.00 49.38  ? 141  THR A O     1 ? 
ATOM   1073 C CB    . THR A 1 139 ? -2.534  -4.661  15.592 1.00 44.15  ? 141  THR A CB    1 ? 
ATOM   1074 O OG1   . THR A 1 139 ? -1.973  -4.845  14.279 1.00 49.69  ? 141  THR A OG1   1 ? 
ATOM   1075 C CG2   . THR A 1 139 ? -2.212  -3.286  16.103 1.00 41.44  ? 141  THR A CG2   1 ? 
ATOM   1076 N N     . ALA A 1 140 ? -1.714  -8.074  16.019 1.00 42.67  ? 142  ALA A N     1 ? 
ATOM   1077 C CA    . ALA A 1 140 ? -2.148  -9.463  15.794 1.00 41.96  ? 142  ALA A CA    1 ? 
ATOM   1078 C C     . ALA A 1 140 ? -2.834  -9.989  17.077 1.00 47.09  ? 142  ALA A C     1 ? 
ATOM   1079 O O     . ALA A 1 140 ? -3.888  -10.616 16.987 1.00 46.03  ? 142  ALA A O     1 ? 
ATOM   1080 C CB    . ALA A 1 140 ? -0.953  -10.300 15.395 1.00 45.68  ? 142  ALA A CB    1 ? 
ATOM   1081 N N     . THR A 1 141 ? -2.216  -9.791  18.252 1.00 47.65  ? 143  THR A N     1 ? 
ATOM   1082 C CA    . THR A 1 141 ? -2.818  -10.229 19.539 1.00 46.49  ? 143  THR A CA    1 ? 
ATOM   1083 C C     . THR A 1 141 ? -3.242  -9.037  20.395 1.00 49.79  ? 143  THR A C     1 ? 
ATOM   1084 O O     . THR A 1 141 ? -3.943  -9.243  21.376 1.00 52.67  ? 143  THR A O     1 ? 
ATOM   1085 C CB    . THR A 1 141 ? -1.839  -11.109 20.302 1.00 44.50  ? 143  THR A CB    1 ? 
ATOM   1086 O OG1   . THR A 1 141 ? -0.923  -10.235 20.955 1.00 49.49  ? 143  THR A OG1   1 ? 
ATOM   1087 C CG2   . THR A 1 141 ? -1.138  -12.102 19.404 1.00 47.63  ? 143  THR A CG2   1 ? 
ATOM   1088 N N     . ASN A 1 142 ? -2.838  -7.833  20.009 1.00 46.32  ? 144  ASN A N     1 ? 
ATOM   1089 C CA    . ASN A 1 142 ? -3.089  -6.586  20.769 1.00 48.94  ? 144  ASN A CA    1 ? 
ATOM   1090 C C     . ASN A 1 142 ? -2.537  -6.631  22.208 1.00 46.50  ? 144  ASN A C     1 ? 
ATOM   1091 O O     . ASN A 1 142 ? -3.073  -5.965  23.081 1.00 55.78  ? 144  ASN A O     1 ? 
ATOM   1092 C CB    . ASN A 1 142 ? -4.578  -6.302  20.764 1.00 44.25  ? 144  ASN A CB    1 ? 
ATOM   1093 C CG    . ASN A 1 142 ? -5.022  -5.893  19.381 1.00 50.72  ? 144  ASN A CG    1 ? 
ATOM   1094 O OD1   . ASN A 1 142 ? -4.491  -4.945  18.817 1.00 56.17  ? 144  ASN A OD1   1 ? 
ATOM   1095 N ND2   . ASN A 1 142 ? -6.041  -6.577  18.874 1.00 51.33  ? 144  ASN A ND2   1 ? 
ATOM   1096 N N     . THR A 1 143 ? -1.458  -7.349  22.425 1.00 48.49  ? 145  THR A N     1 ? 
ATOM   1097 C CA    . THR A 1 143 ? -0.782  -7.382  23.746 1.00 47.93  ? 145  THR A CA    1 ? 
ATOM   1098 C C     . THR A 1 143 ? -0.149  -6.015  24.030 1.00 48.59  ? 145  THR A C     1 ? 
ATOM   1099 O O     . THR A 1 143 ? 0.671   -5.542  23.215 1.00 50.49  ? 145  THR A O     1 ? 
ATOM   1100 C CB    . THR A 1 143 ? 0.300   -8.465  23.795 1.00 44.21  ? 145  THR A CB    1 ? 
ATOM   1101 O OG1   . THR A 1 143 ? -0.151  -9.733  23.321 1.00 52.22  ? 145  THR A OG1   1 ? 
ATOM   1102 C CG2   . THR A 1 143 ? 0.817   -8.624  25.197 1.00 41.66  ? 145  THR A CG2   1 ? 
ATOM   1103 N N     . THR A 1 144 ? -0.533  -5.416  25.145 1.00 49.35  ? 146  THR A N     1 ? 
ATOM   1104 C CA    . THR A 1 144 ? -0.002  -4.115  25.576 1.00 49.85  ? 146  THR A CA    1 ? 
ATOM   1105 C C     . THR A 1 144 ? 1.452   -4.265  26.008 1.00 47.86  ? 146  THR A C     1 ? 
ATOM   1106 O O     . THR A 1 144 ? 1.898   -5.382  26.286 1.00 55.58  ? 146  THR A O     1 ? 
ATOM   1107 C CB    . THR A 1 144 ? -0.829  -3.507  26.712 1.00 51.27  ? 146  THR A CB    1 ? 
ATOM   1108 O OG1   . THR A 1 144 ? -0.791  -4.428  27.805 1.00 53.99  ? 146  THR A OG1   1 ? 
ATOM   1109 C CG2   . THR A 1 144 ? -2.230  -3.196  26.244 1.00 42.10  ? 146  THR A CG2   1 ? 
ATOM   1110 N N     . TYR A 1 145 ? 2.154   -3.141  26.034 1.00 44.11  ? 147  TYR A N     1 ? 
ATOM   1111 C CA    . TYR A 1 145 ? 3.551   -3.111  26.534 1.00 47.20  ? 147  TYR A CA    1 ? 
ATOM   1112 C C     . TYR A 1 145 ? 3.554   -3.482  28.013 1.00 41.43  ? 147  TYR A C     1 ? 
ATOM   1113 O O     . TYR A 1 145 ? 4.404   -4.191  28.428 1.00 46.86  ? 147  TYR A O     1 ? 
ATOM   1114 C CB    . TYR A 1 145 ? 4.204   -1.749  26.259 1.00 46.98  ? 147  TYR A CB    1 ? 
ATOM   1115 C CG    . TYR A 1 145 ? 4.804   -1.627  24.888 1.00 48.76  ? 147  TYR A CG    1 ? 
ATOM   1116 C CD1   . TYR A 1 145 ? 6.082   -2.082  24.639 1.00 47.20  ? 147  TYR A CD1   1 ? 
ATOM   1117 C CD2   . TYR A 1 145 ? 4.086   -1.079  23.834 1.00 49.12  ? 147  TYR A CD2   1 ? 
ATOM   1118 C CE1   . TYR A 1 145 ? 6.648   -1.978  23.386 1.00 47.48  ? 147  TYR A CE1   1 ? 
ATOM   1119 C CE2   . TYR A 1 145 ? 4.619   -1.020  22.560 1.00 44.77  ? 147  TYR A CE2   1 ? 
ATOM   1120 C CZ    . TYR A 1 145 ? 5.911   -1.466  22.335 1.00 47.85  ? 147  TYR A CZ    1 ? 
ATOM   1121 O OH    . TYR A 1 145 ? 6.410   -1.347  21.068 1.00 48.15  ? 147  TYR A OH    1 ? 
ATOM   1122 N N     . LEU A 1 146 ? 2.597   -2.973  28.778 1.00 45.19  ? 148  LEU A N     1 ? 
ATOM   1123 C CA    . LEU A 1 146 ? 2.503   -3.289  30.215 1.00 48.89  ? 148  LEU A CA    1 ? 
ATOM   1124 C C     . LEU A 1 146 ? 2.421   -4.793  30.403 1.00 48.27  ? 148  LEU A C     1 ? 
ATOM   1125 O O     . LEU A 1 146 ? 3.216   -5.316  31.159 1.00 49.73  ? 148  LEU A O     1 ? 
ATOM   1126 C CB    . LEU A 1 146 ? 1.290   -2.608  30.818 1.00 49.72  ? 148  LEU A CB    1 ? 
ATOM   1127 C CG    . LEU A 1 146 ? 1.174   -2.747  32.340 1.00 51.60  ? 148  LEU A CG    1 ? 
ATOM   1128 C CD1   . LEU A 1 146 ? 2.424   -2.287  33.039 1.00 53.66  ? 148  LEU A CD1   1 ? 
ATOM   1129 C CD2   . LEU A 1 146 ? -0.007  -1.939  32.843 1.00 53.82  ? 148  LEU A CD2   1 ? 
ATOM   1130 N N     . ALA A 1 147 ? 1.504   -5.439  29.700 1.00 48.00  ? 149  ALA A N     1 ? 
ATOM   1131 C CA    . ALA A 1 147 ? 1.290   -6.891  29.820 1.00 48.06  ? 149  ALA A CA    1 ? 
ATOM   1132 C C     . ALA A 1 147 ? 2.552   -7.625  29.352 1.00 48.92  ? 149  ALA A C     1 ? 
ATOM   1133 O O     . ALA A 1 147 ? 2.990   -8.557  29.987 1.00 49.64  ? 149  ALA A O     1 ? 
ATOM   1134 C CB    . ALA A 1 147 ? 0.073   -7.320  29.054 1.00 41.89  ? 149  ALA A CB    1 ? 
ATOM   1135 N N     . TYR A 1 148 ? 3.115   -7.184  28.245 1.00 51.62  ? 150  TYR A N     1 ? 
ATOM   1136 C CA    . TYR A 1 148 ? 4.321   -7.791  27.655 1.00 45.62  ? 150  TYR A CA    1 ? 
ATOM   1137 C C     . TYR A 1 148 ? 5.445   -7.810  28.696 1.00 44.61  ? 150  TYR A C     1 ? 
ATOM   1138 O O     . TYR A 1 148 ? 6.009   -8.865  28.948 1.00 53.67  ? 150  TYR A O     1 ? 
ATOM   1139 C CB    . TYR A 1 148 ? 4.711   -7.021  26.398 1.00 41.08  ? 150  TYR A CB    1 ? 
ATOM   1140 C CG    . TYR A 1 148 ? 5.953   -7.489  25.699 1.00 47.65  ? 150  TYR A CG    1 ? 
ATOM   1141 C CD1   . TYR A 1 148 ? 5.908   -8.542  24.809 1.00 43.33  ? 150  TYR A CD1   1 ? 
ATOM   1142 C CD2   . TYR A 1 148 ? 7.160   -6.836  25.900 1.00 43.99  ? 150  TYR A CD2   1 ? 
ATOM   1143 C CE1   . TYR A 1 148 ? 7.050   -8.980  24.160 1.00 47.93  ? 150  TYR A CE1   1 ? 
ATOM   1144 C CE2   . TYR A 1 148 ? 8.312   -7.264  25.265 1.00 45.58  ? 150  TYR A CE2   1 ? 
ATOM   1145 C CZ    . TYR A 1 148 ? 8.257   -8.333  24.382 1.00 43.57  ? 150  TYR A CZ    1 ? 
ATOM   1146 O OH    . TYR A 1 148 ? 9.379   -8.757  23.737 1.00 56.72  ? 150  TYR A OH    1 ? 
ATOM   1147 N N     . TYR A 1 149 ? 5.750   -6.669  29.287 1.00 48.89  ? 151  TYR A N     1 ? 
ATOM   1148 C CA    . TYR A 1 149 ? 6.848   -6.577  30.280 1.00 52.73  ? 151  TYR A CA    1 ? 
ATOM   1149 C C     . TYR A 1 149 ? 6.526   -7.392  31.530 1.00 51.18  ? 151  TYR A C     1 ? 
ATOM   1150 O O     . TYR A 1 149 ? 7.406   -8.131  31.977 1.00 51.30  ? 151  TYR A O     1 ? 
ATOM   1151 C CB    . TYR A 1 149 ? 7.108   -5.129  30.674 1.00 53.04  ? 151  TYR A CB    1 ? 
ATOM   1152 C CG    . TYR A 1 149 ? 7.635   -4.265  29.559 1.00 51.67  ? 151  TYR A CG    1 ? 
ATOM   1153 C CD1   . TYR A 1 149 ? 8.613   -4.714  28.700 1.00 55.14  ? 151  TYR A CD1   1 ? 
ATOM   1154 C CD2   . TYR A 1 149 ? 7.130   -2.995  29.355 1.00 49.99  ? 151  TYR A CD2   1 ? 
ATOM   1155 C CE1   . TYR A 1 149 ? 9.102   -3.903  27.688 1.00 55.62  ? 151  TYR A CE1   1 ? 
ATOM   1156 C CE2   . TYR A 1 149 ? 7.594   -2.176  28.354 1.00 54.95  ? 151  TYR A CE2   1 ? 
ATOM   1157 C CZ    . TYR A 1 149 ? 8.577   -2.633  27.508 1.00 55.60  ? 151  TYR A CZ    1 ? 
ATOM   1158 O OH    . TYR A 1 149 ? 8.987   -1.753  26.559 1.00 51.72  ? 151  TYR A OH    1 ? 
ATOM   1159 N N     . LEU A 1 150 ? 5.311   -7.275  32.056 1.00 53.64  ? 152  LEU A N     1 ? 
ATOM   1160 C CA    . LEU A 1 150 ? 4.930   -7.966  33.311 1.00 50.45  ? 152  LEU A CA    1 ? 
ATOM   1161 C C     . LEU A 1 150 ? 4.906   -9.481  33.115 1.00 51.84  ? 152  LEU A C     1 ? 
ATOM   1162 O O     . LEU A 1 150 ? 5.404   -10.225 33.977 1.00 54.80  ? 152  LEU A O     1 ? 
ATOM   1163 C CB    . LEU A 1 150 ? 3.585   -7.451  33.798 1.00 51.40  ? 152  LEU A CB    1 ? 
ATOM   1164 C CG    . LEU A 1 150 ? 3.629   -6.026  34.348 1.00 51.55  ? 152  LEU A CG    1 ? 
ATOM   1165 C CD1   . LEU A 1 150 ? 2.224   -5.508  34.597 1.00 52.70  ? 152  LEU A CD1   1 ? 
ATOM   1166 C CD2   . LEU A 1 150 ? 4.452   -5.986  35.619 1.00 57.05  ? 152  LEU A CD2   1 ? 
ATOM   1167 N N     . ARG A 1 151 ? 4.366   -9.951  32.009 1.00 53.84  ? 153  ARG A N     1 ? 
ATOM   1168 C CA    . ARG A 1 151 ? 4.299   -11.412 31.787 1.00 54.91  ? 153  ARG A CA    1 ? 
ATOM   1169 C C     . ARG A 1 151 ? 5.698   -11.965 31.550 1.00 53.87  ? 153  ARG A C     1 ? 
ATOM   1170 O O     . ARG A 1 151 ? 5.951   -13.084 31.976 1.00 61.99  ? 153  ARG A O     1 ? 
ATOM   1171 C CB    . ARG A 1 151 ? 3.368   -11.730 30.628 1.00 51.19  ? 153  ARG A CB    1 ? 
ATOM   1172 C CG    . ARG A 1 151 ? 1.917   -11.475 30.980 1.00 58.20  ? 153  ARG A CG    1 ? 
ATOM   1173 C CD    . ARG A 1 151 ? 1.005   -12.523 30.368 1.00 68.60  ? 153  ARG A CD    1 ? 
ATOM   1174 N NE    . ARG A 1 151 ? -0.374  -12.321 30.789 1.00 72.73  ? 153  ARG A NE    1 ? 
ATOM   1175 C CZ    . ARG A 1 151 ? -1.274  -11.582 30.134 1.00 79.29  ? 153  ARG A CZ    1 ? 
ATOM   1176 N NH1   . ARG A 1 151 ? -0.957  -10.973 29.000 1.00 72.07  ? 153  ARG A NH1   1 ? 
ATOM   1177 N NH2   . ARG A 1 151 ? -2.503  -11.466 30.615 1.00 73.28  ? 153  ARG A NH2   1 ? 
ATOM   1178 N N     . TRP A 1 152 ? 6.562   -11.223 30.872 1.00 50.08  ? 154  TRP A N     1 ? 
ATOM   1179 C CA    . TRP A 1 152 ? 7.926   -11.726 30.629 1.00 51.17  ? 154  TRP A CA    1 ? 
ATOM   1180 C C     . TRP A 1 152 ? 8.684   -11.797 31.963 1.00 43.97  ? 154  TRP A C     1 ? 
ATOM   1181 O O     . TRP A 1 152 ? 9.346   -12.775 32.207 1.00 48.22  ? 154  TRP A O     1 ? 
ATOM   1182 C CB    . TRP A 1 152 ? 8.670   -10.868 29.613 1.00 49.44  ? 154  TRP A CB    1 ? 
ATOM   1183 C CG    . TRP A 1 152 ? 10.082  -11.324 29.431 1.00 51.12  ? 154  TRP A CG    1 ? 
ATOM   1184 C CD1   . TRP A 1 152 ? 10.495  -12.419 28.744 1.00 53.15  ? 154  TRP A CD1   1 ? 
ATOM   1185 C CD2   . TRP A 1 152 ? 11.264  -10.722 29.984 1.00 50.90  ? 154  TRP A CD2   1 ? 
ATOM   1186 N NE1   . TRP A 1 152 ? 11.860  -12.517 28.794 1.00 58.21  ? 154  TRP A NE1   1 ? 
ATOM   1187 C CE2   . TRP A 1 152 ? 12.357  -11.491 29.555 1.00 56.45  ? 154  TRP A CE2   1 ? 
ATOM   1188 C CE3   . TRP A 1 152 ? 11.506  -9.582  30.749 1.00 57.27  ? 154  TRP A CE3   1 ? 
ATOM   1189 C CZ2   . TRP A 1 152 ? 13.675  -11.168 29.871 1.00 57.58  ? 154  TRP A CZ2   1 ? 
ATOM   1190 C CZ3   . TRP A 1 152 ? 12.810  -9.257  31.068 1.00 59.20  ? 154  TRP A CZ3   1 ? 
ATOM   1191 C CH2   . TRP A 1 152 ? 13.879  -10.040 30.628 1.00 58.20  ? 154  TRP A CH2   1 ? 
ATOM   1192 N N     . ALA A 1 153 ? 8.583   -10.768 32.782 1.00 45.92  ? 155  ALA A N     1 ? 
ATOM   1193 C CA    . ALA A 1 153 ? 9.219   -10.738 34.119 1.00 51.66  ? 155  ALA A CA    1 ? 
ATOM   1194 C C     . ALA A 1 153 ? 8.678   -11.882 34.992 1.00 56.32  ? 155  ALA A C     1 ? 
ATOM   1195 O O     . ALA A 1 153 ? 9.452   -12.544 35.647 1.00 50.98  ? 155  ALA A O     1 ? 
ATOM   1196 C CB    . ALA A 1 153 ? 8.971   -9.424  34.794 1.00 48.83  ? 155  ALA A CB    1 ? 
ATOM   1197 N N     . GLN A 1 154 ? 7.372   -12.118 34.979 1.00 54.64  ? 156  GLN A N     1 ? 
ATOM   1198 C CA    . GLN A 1 154 ? 6.795   -13.193 35.815 1.00 53.20  ? 156  GLN A CA    1 ? 
ATOM   1199 C C     . GLN A 1 154 ? 7.199   -14.543 35.243 1.00 56.09  ? 156  GLN A C     1 ? 
ATOM   1200 O O     . GLN A 1 154 ? 7.290   -15.511 36.001 1.00 58.00  ? 156  GLN A O     1 ? 
ATOM   1201 C CB    . GLN A 1 154 ? 5.278   -13.121 35.895 1.00 51.34  ? 156  GLN A CB    1 ? 
ATOM   1202 C CG    . GLN A 1 154 ? 4.797   -12.092 36.900 1.00 49.23  ? 156  GLN A CG    1 ? 
ATOM   1203 C CD    . GLN A 1 154 ? 3.285   -12.062 36.989 1.00 60.86  ? 156  GLN A CD    1 ? 
ATOM   1204 O OE1   . GLN A 1 154 ? 2.587   -12.084 35.977 1.00 66.17  ? 156  GLN A OE1   1 ? 
ATOM   1205 N NE2   . GLN A 1 154 ? 2.772   -11.933 38.210 1.00 60.06  ? 156  GLN A NE2   1 ? 
ATOM   1206 N N     . ARG A 1 155 ? 7.446   -14.620 33.948 1.00 55.72  ? 157  ARG A N     1 ? 
ATOM   1207 C CA    . ARG A 1 155 ? 7.925   -15.895 33.385 1.00 50.59  ? 157  ARG A CA    1 ? 
ATOM   1208 C C     . ARG A 1 155 ? 9.371   -16.172 33.806 1.00 55.18  ? 157  ARG A C     1 ? 
ATOM   1209 O O     . ARG A 1 155 ? 9.659   -17.309 34.179 1.00 59.39  ? 157  ARG A O     1 ? 
ATOM   1210 C CB    . ARG A 1 155 ? 7.813   -15.864 31.868 1.00 55.56  ? 157  ARG A CB    1 ? 
ATOM   1211 C CG    . ARG A 1 155 ? 8.092   -17.213 31.236 1.00 57.87  ? 157  ARG A CG    1 ? 
ATOM   1212 C CD    . ARG A 1 155 ? 6.967   -18.181 31.611 1.00 60.32  ? 157  ARG A CD    1 ? 
ATOM   1213 N NE    . ARG A 1 155 ? 7.200   -19.480 31.033 1.00 71.24  ? 157  ARG A NE    1 ? 
ATOM   1214 C CZ    . ARG A 1 155 ? 6.285   -20.442 30.928 1.00 95.71  ? 157  ARG A CZ    1 ? 
ATOM   1215 N NH1   . ARG A 1 155 ? 5.052   -20.232 31.376 1.00 98.20  ? 157  ARG A NH1   1 ? 
ATOM   1216 N NH2   . ARG A 1 155 ? 6.600   -21.602 30.350 1.00 83.43  ? 157  ARG A NH2   1 ? 
ATOM   1217 N N     . VAL A 1 156 ? 10.259  -15.183 33.729 1.00 55.99  ? 158  VAL A N     1 ? 
ATOM   1218 C CA    . VAL A 1 156 ? 11.702  -15.419 33.991 1.00 52.10  ? 158  VAL A CA    1 ? 
ATOM   1219 C C     . VAL A 1 156 ? 12.032  -15.381 35.485 1.00 51.73  ? 158  VAL A C     1 ? 
ATOM   1220 O O     . VAL A 1 156 ? 13.087  -15.914 35.842 1.00 56.66  ? 158  VAL A O     1 ? 
ATOM   1221 C CB    . VAL A 1 156 ? 12.593  -14.414 33.254 1.00 58.50  ? 158  VAL A CB    1 ? 
ATOM   1222 C CG1   . VAL A 1 156 ? 12.732  -14.808 31.798 1.00 55.46  ? 158  VAL A CG1   1 ? 
ATOM   1223 C CG2   . VAL A 1 156 ? 12.137  -12.972 33.434 1.00 61.06  ? 158  VAL A CG2   1 ? 
ATOM   1224 N N     . GLY A 1 157 ? 11.219  -14.740 36.309 1.00 47.57  ? 159  GLY A N     1 ? 
ATOM   1225 C CA    . GLY A 1 157 ? 11.510  -14.560 37.749 1.00 54.63  ? 159  GLY A CA    1 ? 
ATOM   1226 C C     . GLY A 1 157 ? 10.405  -15.086 38.666 1.00 59.12  ? 159  GLY A C     1 ? 
ATOM   1227 O O     . GLY A 1 157 ? 10.433  -14.815 39.869 1.00 65.30  ? 159  GLY A O     1 ? 
ATOM   1228 N N     . GLY A 1 158 ? 9.463   -15.851 38.119 1.00 62.34  ? 160  GLY A N     1 ? 
ATOM   1229 C CA    . GLY A 1 158 ? 8.369   -16.459 38.894 1.00 56.63  ? 160  GLY A CA    1 ? 
ATOM   1230 C C     . GLY A 1 158 ? 7.257   -15.465 39.121 1.00 61.52  ? 160  GLY A C     1 ? 
ATOM   1231 O O     . GLY A 1 158 ? 7.415   -14.261 38.809 1.00 60.97  ? 160  GLY A O     1 ? 
ATOM   1232 N N     . LYS A 1 159 ? 6.156   -15.953 39.664 1.00 61.66  ? 161  LYS A N     1 ? 
ATOM   1233 C CA    . LYS A 1 159 ? 4.967   -15.107 39.881 1.00 63.06  ? 161  LYS A CA    1 ? 
ATOM   1234 C C     . LYS A 1 159 ? 5.284   -13.957 40.837 1.00 63.52  ? 161  LYS A C     1 ? 
ATOM   1235 O O     . LYS A 1 159 ? 4.678   -12.882 40.667 1.00 61.89  ? 161  LYS A O     1 ? 
ATOM   1236 C CB    . LYS A 1 159 ? 3.840   -15.980 40.407 1.00 64.39  ? 161  LYS A CB    1 ? 
ATOM   1237 C CG    . LYS A 1 159 ? 2.492   -15.295 40.483 1.00 59.86  ? 161  LYS A CG    1 ? 
ATOM   1238 C CD    . LYS A 1 159 ? 1.521   -16.175 41.212 1.00 72.23  ? 161  LYS A CD    1 ? 
ATOM   1239 C CE    . LYS A 1 159 ? 0.217   -15.477 41.527 1.00 75.41  ? 161  LYS A CE    1 ? 
ATOM   1240 N NZ    . LYS A 1 159 ? -0.664  -16.356 42.337 1.00 76.99  ? 161  LYS A NZ    1 ? 
ATOM   1241 N N     . GLU A 1 160 ? 6.175   -14.191 41.807 1.00 70.92  ? 162  GLU A N     1 ? 
ATOM   1242 C CA    . GLU A 1 160 ? 6.489   -13.219 42.889 1.00 75.46  ? 162  GLU A CA    1 ? 
ATOM   1243 C C     . GLU A 1 160 ? 7.724   -12.375 42.526 1.00 68.47  ? 162  GLU A C     1 ? 
ATOM   1244 O O     . GLU A 1 160 ? 8.441   -11.920 43.410 1.00 70.66  ? 162  GLU A O     1 ? 
ATOM   1245 C CB    . GLU A 1 160 ? 6.682   -13.968 44.212 1.00 82.44  ? 162  GLU A CB    1 ? 
ATOM   1246 C CG    . GLU A 1 160 ? 5.387   -14.207 44.979 1.00 89.05  ? 162  GLU A CG    1 ? 
ATOM   1247 C CD    . GLU A 1 160 ? 4.655   -15.496 44.618 1.00 102.40 ? 162  GLU A CD    1 ? 
ATOM   1248 O OE1   . GLU A 1 160 ? 5.327   -16.450 44.137 1.00 106.55 ? 162  GLU A OE1   1 ? 
ATOM   1249 O OE2   . GLU A 1 160 ? 3.409   -15.561 44.828 1.00 98.69  ? 162  GLU A OE2   1 ? 
ATOM   1250 N N     . VAL A 1 161 ? 7.957   -12.145 41.254 1.00 69.54  ? 163  VAL A N     1 ? 
ATOM   1251 C CA    . VAL A 1 161 ? 9.101   -11.322 40.783 1.00 68.46  ? 163  VAL A CA    1 ? 
ATOM   1252 C C     . VAL A 1 161 ? 8.926   -9.891  41.287 1.00 61.67  ? 163  VAL A C     1 ? 
ATOM   1253 O O     . VAL A 1 161 ? 7.851   -9.315  41.200 1.00 63.37  ? 163  VAL A O     1 ? 
ATOM   1254 C CB    . VAL A 1 161 ? 9.215   -11.369 39.248 1.00 67.91  ? 163  VAL A CB    1 ? 
ATOM   1255 C CG1   . VAL A 1 161 ? 7.946   -10.859 38.582 1.00 64.40  ? 163  VAL A CG1   1 ? 
ATOM   1256 C CG2   . VAL A 1 161 ? 10.437  -10.614 38.752 1.00 60.51  ? 163  VAL A CG2   1 ? 
ATOM   1257 N N     . PRO A 1 162 ? 9.989   -9.257  41.808 1.00 58.85  ? 164  PRO A N     1 ? 
ATOM   1258 C CA    . PRO A 1 162 ? 9.911   -7.858  42.192 1.00 60.90  ? 164  PRO A CA    1 ? 
ATOM   1259 C C     . PRO A 1 162 ? 9.856   -6.965  40.946 1.00 56.65  ? 164  PRO A C     1 ? 
ATOM   1260 O O     . PRO A 1 162 ? 10.685  -7.094  40.048 1.00 52.33  ? 164  PRO A O     1 ? 
ATOM   1261 C CB    . PRO A 1 162 ? 11.205  -7.593  42.982 1.00 56.19  ? 164  PRO A CB    1 ? 
ATOM   1262 C CG    . PRO A 1 162 ? 11.786  -8.955  43.225 1.00 58.82  ? 164  PRO A CG    1 ? 
ATOM   1263 C CD    . PRO A 1 162 ? 11.310  -9.832  42.083 1.00 57.45  ? 164  PRO A CD    1 ? 
ATOM   1264 N N     . PHE A 1 163 ? 8.836   -6.119  40.913 1.00 60.42  ? 165  PHE A N     1 ? 
ATOM   1265 C CA    . PHE A 1 163 ? 8.555   -5.239  39.763 1.00 56.61  ? 165  PHE A CA    1 ? 
ATOM   1266 C C     . PHE A 1 163 ? 8.151   -3.888  40.303 1.00 54.13  ? 165  PHE A C     1 ? 
ATOM   1267 O O     . PHE A 1 163 ? 7.306   -3.823  41.178 1.00 59.51  ? 165  PHE A O     1 ? 
ATOM   1268 C CB    . PHE A 1 163 ? 7.479   -5.804  38.839 1.00 58.70  ? 165  PHE A CB    1 ? 
ATOM   1269 C CG    . PHE A 1 163 ? 7.616   -5.338  37.413 1.00 55.30  ? 165  PHE A CG    1 ? 
ATOM   1270 C CD1   . PHE A 1 163 ? 7.232   -4.062  37.046 1.00 54.47  ? 165  PHE A CD1   1 ? 
ATOM   1271 C CD2   . PHE A 1 163 ? 8.185   -6.168  36.456 1.00 54.45  ? 165  PHE A CD2   1 ? 
ATOM   1272 C CE1   . PHE A 1 163 ? 7.373   -3.641  35.732 1.00 57.35  ? 165  PHE A CE1   1 ? 
ATOM   1273 C CE2   . PHE A 1 163 ? 8.295   -5.763  35.139 1.00 54.62  ? 165  PHE A CE2   1 ? 
ATOM   1274 C CZ    . PHE A 1 163 ? 7.880   -4.501  34.779 1.00 56.66  ? 165  PHE A CZ    1 ? 
ATOM   1275 N N     . VAL A 1 164 ? 8.768   -2.850  39.745 1.00 61.25  ? 166  VAL A N     1 ? 
ATOM   1276 C CA    . VAL A 1 164 ? 8.458   -1.439  40.090 1.00 60.35  ? 166  VAL A CA    1 ? 
ATOM   1277 C C     . VAL A 1 164 ? 7.994   -0.730  38.828 1.00 58.51  ? 166  VAL A C     1 ? 
ATOM   1278 O O     . VAL A 1 164 ? 8.612   -0.891  37.777 1.00 56.09  ? 166  VAL A O     1 ? 
ATOM   1279 C CB    . VAL A 1 164 ? 9.688   -0.754  40.692 1.00 60.88  ? 166  VAL A CB    1 ? 
ATOM   1280 C CG1   . VAL A 1 164 ? 9.409   0.708   40.985 1.00 55.67  ? 166  VAL A CG1   1 ? 
ATOM   1281 C CG2   . VAL A 1 164 ? 10.154  -1.501  41.932 1.00 61.04  ? 166  VAL A CG2   1 ? 
ATOM   1282 N N     . ILE A 1 165 ? 6.939   0.034   38.944 1.00 55.26  ? 167  ILE A N     1 ? 
ATOM   1283 C CA    . ILE A 1 165 ? 6.479   0.908   37.851 1.00 60.64  ? 167  ILE A CA    1 ? 
ATOM   1284 C C     . ILE A 1 165 ? 6.405   2.323   38.402 1.00 58.36  ? 167  ILE A C     1 ? 
ATOM   1285 O O     . ILE A 1 165 ? 5.627   2.537   39.356 1.00 63.31  ? 167  ILE A O     1 ? 
ATOM   1286 C CB    . ILE A 1 165 ? 5.124   0.440   37.306 1.00 60.15  ? 167  ILE A CB    1 ? 
ATOM   1287 C CG1   . ILE A 1 165 ? 5.228   -0.966  36.724 1.00 57.96  ? 167  ILE A CG1   1 ? 
ATOM   1288 C CG2   . ILE A 1 165 ? 4.610   1.440   36.278 1.00 53.82  ? 167  ILE A CG2   1 ? 
ATOM   1289 C CD1   . ILE A 1 165 ? 3.899   -1.548  36.336 1.00 54.39  ? 167  ILE A CD1   1 ? 
ATOM   1290 N N     . MET A 1 166 ? 7.141   3.236   37.782 1.00 54.38  ? 168  MET A N     1 ? 
ATOM   1291 C CA    . MET A 1 166 ? 7.006   4.675   38.071 1.00 54.44  ? 168  MET A CA    1 ? 
ATOM   1292 C C     . MET A 1 166 ? 5.893   5.261   37.214 1.00 52.70  ? 168  MET A C     1 ? 
ATOM   1293 O O     . MET A 1 166 ? 5.904   5.091   35.993 1.00 56.08  ? 168  MET A O     1 ? 
ATOM   1294 C CB    . MET A 1 166 ? 8.287   5.451   37.795 1.00 56.57  ? 168  MET A CB    1 ? 
ATOM   1295 C CG    . MET A 1 166 ? 8.122   6.900   38.169 1.00 55.20  ? 168  MET A CG    1 ? 
ATOM   1296 S SD    . MET A 1 166 ? 9.664   7.742   38.472 1.00 58.61  ? 168  MET A SD    1 ? 
ATOM   1297 C CE    . MET A 1 166 ? 10.262  7.899   36.791 1.00 52.79  ? 168  MET A CE    1 ? 
ATOM   1298 N N     . THR A 1 167 ? 4.960   5.920   37.870 1.00 55.70  ? 169  THR A N     1 ? 
ATOM   1299 C CA    . THR A 1 167 ? 3.838   6.606   37.210 1.00 54.36  ? 169  THR A CA    1 ? 
ATOM   1300 C C     . THR A 1 167 ? 3.934   8.098   37.498 1.00 54.62  ? 169  THR A C     1 ? 
ATOM   1301 O O     . THR A 1 167 ? 4.853   8.516   38.214 1.00 58.02  ? 169  THR A O     1 ? 
ATOM   1302 C CB    . THR A 1 167 ? 2.512   6.023   37.690 1.00 53.97  ? 169  THR A CB    1 ? 
ATOM   1303 O OG1   . THR A 1 167 ? 2.478   6.217   39.107 1.00 55.90  ? 169  THR A OG1   1 ? 
ATOM   1304 C CG2   . THR A 1 167 ? 2.390   4.571   37.282 1.00 54.72  ? 169  THR A CG2   1 ? 
ATOM   1305 N N     . SER A 1 168 ? 2.977   8.838   36.975 1.00 59.87  ? 170  SER A N     1 ? 
ATOM   1306 C CA    . SER A 1 168 ? 2.874   10.297  37.169 1.00 57.06  ? 170  SER A CA    1 ? 
ATOM   1307 C C     . SER A 1 168 ? 1.409   10.650  37.343 1.00 55.82  ? 170  SER A C     1 ? 
ATOM   1308 O O     . SER A 1 168 ? 0.568   9.765   37.208 1.00 63.90  ? 170  SER A O     1 ? 
ATOM   1309 C CB    . SER A 1 168 ? 3.508   11.049  35.982 1.00 59.50  ? 170  SER A CB    1 ? 
ATOM   1310 O OG    . SER A 1 168 ? 2.675   11.051  34.815 1.00 58.79  ? 170  SER A OG    1 ? 
ATOM   1311 N N     . ASP A 1 169 ? 1.118   11.927  37.558 1.00 61.65  ? 171  ASP A N     1 ? 
ATOM   1312 C CA    . ASP A 1 169 ? -0.283  12.392  37.672 1.00 64.38  ? 171  ASP A CA    1 ? 
ATOM   1313 C C     . ASP A 1 169 ? -1.004  12.155  36.344 1.00 62.04  ? 171  ASP A C     1 ? 
ATOM   1314 O O     . ASP A 1 169 ? -2.233  12.107  36.346 1.00 63.55  ? 171  ASP A O     1 ? 
ATOM   1315 C CB    . ASP A 1 169 ? -0.325  13.862  38.083 1.00 64.80  ? 171  ASP A CB    1 ? 
ATOM   1316 C CG    . ASP A 1 169 ? 0.324   14.143  39.423 1.00 69.20  ? 171  ASP A CG    1 ? 
ATOM   1317 O OD1   . ASP A 1 169 ? 0.755   13.181  40.072 1.00 75.34  ? 171  ASP A OD1   1 ? 
ATOM   1318 O OD2   . ASP A 1 169 ? 0.400   15.325  39.795 1.00 82.69  ? 171  ASP A OD2   1 ? 
ATOM   1319 N N     . ASP A 1 170 ? -0.249  11.993  35.262 1.00 68.09  ? 172  ASP A N     1 ? 
ATOM   1320 C CA    . ASP A 1 170 ? -0.857  11.804  33.920 1.00 72.76  ? 172  ASP A CA    1 ? 
ATOM   1321 C C     . ASP A 1 170 ? -1.104  10.319  33.637 1.00 66.16  ? 172  ASP A C     1 ? 
ATOM   1322 O O     . ASP A 1 170 ? -1.977  10.033  32.808 1.00 69.78  ? 172  ASP A O     1 ? 
ATOM   1323 C CB    . ASP A 1 170 ? 0.019   12.442  32.843 1.00 75.26  ? 172  ASP A CB    1 ? 
ATOM   1324 C CG    . ASP A 1 170 ? 0.369   13.904  33.130 1.00 95.87  ? 172  ASP A CG    1 ? 
ATOM   1325 O OD1   . ASP A 1 170 ? -0.533  14.772  32.939 1.00 91.11  ? 172  ASP A OD1   1 ? 
ATOM   1326 O OD2   . ASP A 1 170 ? 1.550   14.184  33.556 1.00 86.40  ? 172  ASP A OD2   1 ? 
ATOM   1327 N N     . THR A 1 171 ? -0.415  9.400   34.306 1.00 59.59  ? 173  THR A N     1 ? 
ATOM   1328 C CA    . THR A 1 171 ? -0.480  7.970   33.917 1.00 63.35  ? 173  THR A CA    1 ? 
ATOM   1329 C C     . THR A 1 171 ? -0.945  7.049   35.036 1.00 59.07  ? 173  THR A C     1 ? 
ATOM   1330 O O     . THR A 1 171 ? -1.254  5.891   34.708 1.00 59.09  ? 173  THR A O     1 ? 
ATOM   1331 C CB    . THR A 1 171 ? 0.879   7.508   33.380 1.00 63.17  ? 173  THR A CB    1 ? 
ATOM   1332 O OG1   . THR A 1 171 ? 1.879   7.562   34.397 1.00 59.49  ? 173  THR A OG1   1 ? 
ATOM   1333 C CG2   . THR A 1 171 ? 1.314   8.352   32.206 1.00 65.82  ? 173  THR A CG2   1 ? 
ATOM   1334 N N     . HIS A 1 172 ? -0.954  7.515   36.282 1.00 57.63  ? 174  HIS A N     1 ? 
ATOM   1335 C CA    . HIS A 1 172 ? -1.156  6.639   37.467 1.00 57.80  ? 174  HIS A CA    1 ? 
ATOM   1336 C C     . HIS A 1 172 ? -2.507  5.941   37.373 1.00 53.18  ? 174  HIS A C     1 ? 
ATOM   1337 O O     . HIS A 1 172 ? -2.543  4.713   37.334 1.00 60.55  ? 174  HIS A O     1 ? 
ATOM   1338 C CB    . HIS A 1 172 ? -1.009  7.448   38.766 1.00 60.68  ? 174  HIS A CB    1 ? 
ATOM   1339 C CG    . HIS A 1 172 ? -1.099  6.626   40.013 1.00 60.53  ? 174  HIS A CG    1 ? 
ATOM   1340 N ND1   . HIS A 1 172 ? -0.077  5.801   40.435 1.00 57.78  ? 174  HIS A ND1   1 ? 
ATOM   1341 C CD2   . HIS A 1 172 ? -2.092  6.491   40.914 1.00 59.24  ? 174  HIS A CD2   1 ? 
ATOM   1342 C CE1   . HIS A 1 172 ? -0.438  5.183   41.535 1.00 58.09  ? 174  HIS A CE1   1 ? 
ATOM   1343 N NE2   . HIS A 1 172 ? -1.659  5.604   41.855 1.00 64.52  ? 174  HIS A NE2   1 ? 
ATOM   1344 N N     . ASP A 1 173 ? -3.593  6.696   37.392 1.00 58.21  ? 175  ASP A N     1 ? 
ATOM   1345 C CA    . ASP A 1 173 ? -4.940  6.077   37.442 1.00 60.90  ? 175  ASP A CA    1 ? 
ATOM   1346 C C     . ASP A 1 173 ? -5.117  5.095   36.287 1.00 60.52  ? 175  ASP A C     1 ? 
ATOM   1347 O O     . ASP A 1 173 ? -5.575  3.976   36.538 1.00 67.57  ? 175  ASP A O     1 ? 
ATOM   1348 C CB    . ASP A 1 173 ? -6.021  7.156   37.497 1.00 68.07  ? 175  ASP A CB    1 ? 
ATOM   1349 C CG    . ASP A 1 173 ? -6.134  7.836   38.847 1.00 72.11  ? 175  ASP A CG    1 ? 
ATOM   1350 O OD1   . ASP A 1 173 ? -5.710  7.227   39.842 1.00 80.77  ? 175  ASP A OD1   1 ? 
ATOM   1351 O OD2   . ASP A 1 173 ? -6.641  8.970   38.889 1.00 75.45  ? 175  ASP A OD2   1 ? 
ATOM   1352 N N     . ARG A 1 174 ? -4.737  5.490   35.081 1.00 62.75  ? 176  ARG A N     1 ? 
ATOM   1353 C CA    . ARG A 1 174 ? -4.974  4.629   33.898 1.00 61.37  ? 176  ARG A CA    1 ? 
ATOM   1354 C C     . ARG A 1 174 ? -4.089  3.383   33.964 1.00 53.77  ? 176  ARG A C     1 ? 
ATOM   1355 O O     . ARG A 1 174 ? -4.563  2.342   33.582 1.00 60.91  ? 176  ARG A O     1 ? 
ATOM   1356 C CB    . ARG A 1 174 ? -4.814  5.453   32.619 1.00 66.97  ? 176  ARG A CB    1 ? 
ATOM   1357 C CG    . ARG A 1 174 ? -5.965  6.416   32.366 1.00 73.28  ? 176  ARG A CG    1 ? 
ATOM   1358 C CD    . ARG A 1 174 ? -5.800  7.271   31.124 1.00 75.41  ? 176  ARG A CD    1 ? 
ATOM   1359 N NE    . ARG A 1 174 ? -4.745  8.264   31.249 1.00 71.09  ? 176  ARG A NE    1 ? 
ATOM   1360 C CZ    . ARG A 1 174 ? -4.410  9.121   30.296 1.00 66.23  ? 176  ARG A CZ    1 ? 
ATOM   1361 N NH1   . ARG A 1 174 ? -5.054  9.110   29.143 1.00 67.78  ? 176  ARG A NH1   1 ? 
ATOM   1362 N NH2   . ARG A 1 174 ? -3.436  9.989   30.497 1.00 68.96  ? 176  ARG A NH2   1 ? 
ATOM   1363 N N     . THR A 1 175 ? -2.888  3.489   34.506 1.00 55.78  ? 177  THR A N     1 ? 
ATOM   1364 C CA    . THR A 1 175 ? -2.016  2.297   34.659 1.00 55.54  ? 177  THR A CA    1 ? 
ATOM   1365 C C     . THR A 1 175 ? -2.722  1.277   35.556 1.00 49.15  ? 177  THR A C     1 ? 
ATOM   1366 O O     . THR A 1 175 ? -2.756  0.089   35.201 1.00 52.26  ? 177  THR A O     1 ? 
ATOM   1367 C CB    . THR A 1 175 ? -0.617  2.703   35.142 1.00 44.85  ? 177  THR A CB    1 ? 
ATOM   1368 O OG1   . THR A 1 175 ? -0.093  3.654   34.219 1.00 54.76  ? 177  THR A OG1   1 ? 
ATOM   1369 C CG2   . THR A 1 175 ? 0.329   1.531   35.274 1.00 47.52  ? 177  THR A CG2   1 ? 
ATOM   1370 N N     . LEU A 1 176 ? -3.301  1.744   36.652 1.00 53.33  ? 178  LEU A N     1 ? 
ATOM   1371 C CA    . LEU A 1 176 ? -3.946  0.829   37.620 1.00 52.16  ? 178  LEU A CA    1 ? 
ATOM   1372 C C     . LEU A 1 176 ? -5.201  0.255   36.971 1.00 52.49  ? 178  LEU A C     1 ? 
ATOM   1373 O O     . LEU A 1 176 ? -5.459  -0.954  37.116 1.00 53.03  ? 178  LEU A O     1 ? 
ATOM   1374 C CB    . LEU A 1 176 ? -4.248  1.631   38.888 1.00 54.07  ? 178  LEU A CB    1 ? 
ATOM   1375 C CG    . LEU A 1 176 ? -3.169  1.618   39.967 1.00 58.41  ? 178  LEU A CG    1 ? 
ATOM   1376 C CD1   . LEU A 1 176 ? -1.785  1.820   39.378 1.00 58.28  ? 178  LEU A CD1   1 ? 
ATOM   1377 C CD2   . LEU A 1 176 ? -3.454  2.670   41.023 1.00 62.12  ? 178  LEU A CD2   1 ? 
ATOM   1378 N N     . GLN A 1 177 ? -5.897  1.089   36.215 1.00 57.40  ? 179  GLN A N     1 ? 
ATOM   1379 C CA    . GLN A 1 177 ? -7.102  0.610   35.512 1.00 62.26  ? 179  GLN A CA    1 ? 
ATOM   1380 C C     . GLN A 1 177 ? -6.702  -0.517  34.567 1.00 60.82  ? 179  GLN A C     1 ? 
ATOM   1381 O O     . GLN A 1 177 ? -7.413  -1.502  34.537 1.00 59.56  ? 179  GLN A O     1 ? 
ATOM   1382 C CB    . GLN A 1 177 ? -7.743  1.761   34.746 1.00 69.85  ? 179  GLN A CB    1 ? 
ATOM   1383 C CG    . GLN A 1 177 ? -8.961  1.363   33.934 1.00 78.28  ? 179  GLN A CG    1 ? 
ATOM   1384 C CD    . GLN A 1 177 ? -9.330  2.435   32.941 1.00 93.71  ? 179  GLN A CD    1 ? 
ATOM   1385 O OE1   . GLN A 1 177 ? -8.727  3.504   32.902 1.00 92.00  ? 179  GLN A OE1   1 ? 
ATOM   1386 N NE2   . GLN A 1 177 ? -10.327 2.151   32.121 1.00 96.59  ? 179  GLN A NE2   1 ? 
ATOM   1387 N N     . LEU A 1 178 ? -5.596  -0.360  33.847 1.00 55.96  ? 180  LEU A N     1 ? 
ATOM   1388 C CA    . LEU A 1 178 ? -5.146  -1.371  32.864 1.00 56.47  ? 180  LEU A CA    1 ? 
ATOM   1389 C C     . LEU A 1 178 ? -4.742  -2.640  33.602 1.00 51.35  ? 180  LEU A C     1 ? 
ATOM   1390 O O     . LEU A 1 178 ? -5.109  -3.702  33.139 1.00 55.27  ? 180  LEU A O     1 ? 
ATOM   1391 C CB    . LEU A 1 178 ? -3.976  -0.806  32.056 1.00 49.94  ? 180  LEU A CB    1 ? 
ATOM   1392 C CG    . LEU A 1 178 ? -3.536  -1.630  30.849 1.00 51.07  ? 180  LEU A CG    1 ? 
ATOM   1393 C CD1   . LEU A 1 178 ? -4.696  -1.859  29.897 1.00 44.59  ? 180  LEU A CD1   1 ? 
ATOM   1394 C CD2   . LEU A 1 178 ? -2.384  -0.954  30.127 1.00 57.39  ? 180  LEU A CD2   1 ? 
ATOM   1395 N N     . LEU A 1 179 ? -4.047  -2.504  34.725 1.00 55.41  ? 181  LEU A N     1 ? 
ATOM   1396 C CA    . LEU A 1 179 ? -3.693  -3.706  35.512 1.00 56.69  ? 181  LEU A CA    1 ? 
ATOM   1397 C C     . LEU A 1 179 ? -4.985  -4.451  35.836 1.00 55.70  ? 181  LEU A C     1 ? 
ATOM   1398 O O     . LEU A 1 179 ? -5.073  -5.630  35.520 1.00 51.43  ? 181  LEU A O     1 ? 
ATOM   1399 C CB    . LEU A 1 179 ? -2.932  -3.274  36.764 1.00 51.13  ? 181  LEU A CB    1 ? 
ATOM   1400 C CG    . LEU A 1 179 ? -1.507  -2.785  36.524 1.00 55.68  ? 181  LEU A CG    1 ? 
ATOM   1401 C CD1   . LEU A 1 179 ? -0.971  -2.061  37.746 1.00 55.21  ? 181  LEU A CD1   1 ? 
ATOM   1402 C CD2   . LEU A 1 179 ? -0.598  -3.940  36.147 1.00 56.93  ? 181  LEU A CD2   1 ? 
ATOM   1403 N N     . ARG A 1 180 ? -5.997  -3.750  36.315 1.00 58.05  ? 182  ARG A N     1 ? 
ATOM   1404 C CA    . ARG A 1 180 ? -7.273  -4.401  36.682 1.00 60.96  ? 182  ARG A CA    1 ? 
ATOM   1405 C C     . ARG A 1 180 ? -7.892  -5.059  35.446 1.00 61.34  ? 182  ARG A C     1 ? 
ATOM   1406 O O     . ARG A 1 180 ? -8.212  -6.243  35.528 1.00 59.66  ? 182  ARG A O     1 ? 
ATOM   1407 C CB    . ARG A 1 180 ? -8.183  -3.351  37.322 1.00 58.22  ? 182  ARG A CB    1 ? 
ATOM   1408 C CG    . ARG A 1 180 ? -9.558  -3.851  37.728 1.00 68.70  ? 182  ARG A CG    1 ? 
ATOM   1409 C CD    . ARG A 1 180 ? -10.350 -2.710  38.335 1.00 64.85  ? 182  ARG A CD    1 ? 
ATOM   1410 N NE    . ARG A 1 180 ? -9.678  -2.144  39.494 1.00 73.40  ? 182  ARG A NE    1 ? 
ATOM   1411 C CZ    . ARG A 1 180 ? -9.895  -2.522  40.747 1.00 73.41  ? 182  ARG A CZ    1 ? 
ATOM   1412 N NH1   . ARG A 1 180 ? -10.778 -3.468  41.008 1.00 74.90  ? 182  ARG A NH1   1 ? 
ATOM   1413 N NH2   . ARG A 1 180 ? -9.234  -1.950  41.735 1.00 68.71  ? 182  ARG A NH2   1 ? 
ATOM   1414 N N     . GLU A 1 181 ? -7.999  -4.334  34.336 1.00 61.66  ? 183  GLU A N     1 ? 
ATOM   1415 C CA    . GLU A 1 181 ? -8.678  -4.840  33.114 1.00 56.67  ? 183  GLU A CA    1 ? 
ATOM   1416 C C     . GLU A 1 181 ? -7.943  -6.050  32.531 1.00 52.28  ? 183  GLU A C     1 ? 
ATOM   1417 O O     . GLU A 1 181 ? -8.598  -6.860  31.867 1.00 58.73  ? 183  GLU A O     1 ? 
ATOM   1418 C CB    . GLU A 1 181 ? -8.793  -3.731  32.072 1.00 50.42  ? 183  GLU A CB    1 ? 
ATOM   1419 C CG    . GLU A 1 181 ? -9.590  -2.531  32.523 1.00 60.55  ? 183  GLU A CG    1 ? 
ATOM   1420 C CD    . GLU A 1 181 ? -9.510  -1.380  31.538 1.00 70.16  ? 183  GLU A CD    1 ? 
ATOM   1421 O OE1   . GLU A 1 181 ? -8.658  -1.441  30.636 1.00 72.81  ? 183  GLU A OE1   1 ? 
ATOM   1422 O OE2   . GLU A 1 181 ? -10.306 -0.438  31.669 1.00 69.96  ? 183  GLU A OE2   1 ? 
ATOM   1423 N N     . LEU A 1 182 ? -6.640  -6.160  32.765 1.00 58.43  ? 184  LEU A N     1 ? 
ATOM   1424 C CA    . LEU A 1 182 ? -5.900  -7.282  32.154 1.00 59.68  ? 184  LEU A CA    1 ? 
ATOM   1425 C C     . LEU A 1 182 ? -5.921  -8.403  33.175 1.00 59.76  ? 184  LEU A C     1 ? 
ATOM   1426 O O     . LEU A 1 182 ? -5.492  -9.548  32.863 1.00 65.27  ? 184  LEU A O     1 ? 
ATOM   1427 C CB    . LEU A 1 182 ? -4.477  -6.835  31.828 1.00 65.90  ? 184  LEU A CB    1 ? 
ATOM   1428 C CG    . LEU A 1 182 ? -4.242  -6.381  30.388 1.00 65.84  ? 184  LEU A CG    1 ? 
ATOM   1429 C CD1   . LEU A 1 182 ? -5.499  -5.775  29.787 1.00 70.00  ? 184  LEU A CD1   1 ? 
ATOM   1430 C CD2   . LEU A 1 182 ? -3.084  -5.403  30.311 1.00 65.01  ? 184  LEU A CD2   1 ? 
ATOM   1431 N N     . GLN A 1 183 ? -6.466  -8.066  34.341 1.00 71.43  ? 185  GLN A N     1 ? 
ATOM   1432 C CA    . GLN A 1 183 ? -6.543  -9.105  35.409 1.00 70.63  ? 185  GLN A CA    1 ? 
ATOM   1433 C C     . GLN A 1 183 ? -5.143  -9.671  35.627 1.00 70.63  ? 185  GLN A C     1 ? 
ATOM   1434 O O     . GLN A 1 183 ? -4.950  -10.910 35.679 1.00 67.85  ? 185  GLN A O     1 ? 
ATOM   1435 C CB    . GLN A 1 183 ? -7.561  -10.184 35.021 1.00 77.30  ? 185  GLN A CB    1 ? 
ATOM   1436 C CG    . GLN A 1 183 ? -8.993  -9.770  35.357 1.00 81.38  ? 185  GLN A CG    1 ? 
ATOM   1437 C CD    . GLN A 1 183 ? -10.018 -10.149 34.316 1.00 93.38  ? 185  GLN A CD    1 ? 
ATOM   1438 O OE1   . GLN A 1 183 ? -10.962 -9.376  34.049 1.00 83.10  ? 185  GLN A OE1   1 ? 
ATOM   1439 N NE2   . GLN A 1 183 ? -9.854  -11.345 33.752 1.00 93.00  ? 185  GLN A NE2   1 ? 
ATOM   1440 N N     . LEU A 1 184 ? -4.174  -8.769  35.708 1.00 76.39  ? 186  LEU A N     1 ? 
ATOM   1441 C CA    . LEU A 1 184 ? -2.772  -9.141  36.001 1.00 78.17  ? 186  LEU A CA    1 ? 
ATOM   1442 C C     . LEU A 1 184 ? -2.578  -9.134  37.519 1.00 84.50  ? 186  LEU A C     1 ? 
ATOM   1443 O O     . LEU A 1 184 ? -2.784  -8.071  38.161 1.00 81.02  ? 186  LEU A O     1 ? 
ATOM   1444 C CB    . LEU A 1 184 ? -1.826  -8.142  35.334 1.00 81.53  ? 186  LEU A CB    1 ? 
ATOM   1445 C CG    . LEU A 1 184 ? -1.562  -8.354  33.846 1.00 81.28  ? 186  LEU A CG    1 ? 
ATOM   1446 C CD1   . LEU A 1 184 ? -0.821  -7.155  33.277 1.00 79.53  ? 186  LEU A CD1   1 ? 
ATOM   1447 C CD2   . LEU A 1 184 ? -0.767  -9.631  33.613 1.00 77.47  ? 186  LEU A CD2   1 ? 
ATOM   1448 N N     . GLU A 1 185 ? -2.198  -10.281 38.069 1.00 77.53  ? 187  GLU A N     1 ? 
ATOM   1449 C CA    . GLU A 1 185 ? -1.996  -10.434 39.521 1.00 86.89  ? 187  GLU A CA    1 ? 
ATOM   1450 C C     . GLU A 1 185 ? -0.490  -10.570 39.783 1.00 77.05  ? 187  GLU A C     1 ? 
ATOM   1451 O O     . GLU A 1 185 ? 0.077   -11.658 39.590 1.00 62.10  ? 187  GLU A O     1 ? 
ATOM   1452 C CB    . GLU A 1 185 ? -2.831  -11.607 40.033 1.00 92.34  ? 187  GLU A CB    1 ? 
ATOM   1453 C CG    . GLU A 1 185 ? -2.941  -11.654 41.553 1.00 105.20 ? 187  GLU A CG    1 ? 
ATOM   1454 C CD    . GLU A 1 185 ? -3.462  -12.983 42.106 1.00 108.50 ? 187  GLU A CD    1 ? 
ATOM   1455 O OE1   . GLU A 1 185 ? -4.322  -13.642 41.425 1.00 104.78 ? 187  GLU A OE1   1 ? 
ATOM   1456 O OE2   . GLU A 1 185 ? -3.011  -13.386 43.213 1.00 97.96  ? 187  GLU A OE2   1 ? 
ATOM   1457 N N     . VAL A 1 186 ? 0.128   -9.478  40.225 1.00 74.00  ? 188  VAL A N     1 ? 
ATOM   1458 C CA    . VAL A 1 186 ? 1.594   -9.432  40.490 1.00 70.66  ? 188  VAL A CA    1 ? 
ATOM   1459 C C     . VAL A 1 186 ? 1.799   -9.113  41.961 1.00 64.45  ? 188  VAL A C     1 ? 
ATOM   1460 O O     . VAL A 1 186 ? 1.711   -7.952  42.376 1.00 64.46  ? 188  VAL A O     1 ? 
ATOM   1461 C CB    . VAL A 1 186 ? 2.299   -8.408  39.581 1.00 59.79  ? 188  VAL A CB    1 ? 
ATOM   1462 C CG1   . VAL A 1 186 ? 3.780   -8.688  39.502 1.00 60.01  ? 188  VAL A CG1   1 ? 
ATOM   1463 C CG2   . VAL A 1 186 ? 1.717   -8.414  38.194 1.00 62.10  ? 188  VAL A CG2   1 ? 
ATOM   1464 N N     . PRO A 1 187 ? 2.026   -10.138 42.801 1.00 67.53  ? 189  PRO A N     1 ? 
ATOM   1465 C CA    . PRO A 1 187 ? 2.073   -9.927  44.250 1.00 66.02  ? 189  PRO A CA    1 ? 
ATOM   1466 C C     . PRO A 1 187 ? 3.113   -8.901  44.729 1.00 59.40  ? 189  PRO A C     1 ? 
ATOM   1467 O O     . PRO A 1 187 ? 2.820   -8.156  45.620 1.00 65.16  ? 189  PRO A O     1 ? 
ATOM   1468 C CB    . PRO A 1 187 ? 2.422   -11.317 44.803 1.00 67.27  ? 189  PRO A CB    1 ? 
ATOM   1469 C CG    . PRO A 1 187 ? 1.925   -12.257 43.729 1.00 73.62  ? 189  PRO A CG    1 ? 
ATOM   1470 C CD    . PRO A 1 187 ? 2.215   -11.544 42.424 1.00 68.32  ? 189  PRO A CD    1 ? 
ATOM   1471 N N     . ASN A 1 188 ? 4.285   -8.861  44.113 1.00 59.33  ? 190  ASN A N     1 ? 
ATOM   1472 C CA    . ASN A 1 188 ? 5.367   -7.938  44.526 1.00 62.86  ? 190  ASN A CA    1 ? 
ATOM   1473 C C     . ASN A 1 188 ? 5.518   -6.785  43.533 1.00 66.61  ? 190  ASN A C     1 ? 
ATOM   1474 O O     . ASN A 1 188 ? 6.644   -6.295  43.349 1.00 59.53  ? 190  ASN A O     1 ? 
ATOM   1475 C CB    . ASN A 1 188 ? 6.680   -8.689  44.672 1.00 69.77  ? 190  ASN A CB    1 ? 
ATOM   1476 C CG    . ASN A 1 188 ? 6.611   -9.657  45.831 1.00 76.89  ? 190  ASN A CG    1 ? 
ATOM   1477 O OD1   . ASN A 1 188 ? 6.158   -9.289  46.917 1.00 75.77  ? 190  ASN A OD1   1 ? 
ATOM   1478 N ND2   . ASN A 1 188 ? 6.993   -10.897 45.595 1.00 71.57  ? 190  ASN A ND2   1 ? 
ATOM   1479 N N     . LEU A 1 189 ? 4.424   -6.344  42.929 1.00 61.01  ? 191  LEU A N     1 ? 
ATOM   1480 C CA    . LEU A 1 189 ? 4.441   -5.117  42.119 1.00 56.24  ? 191  LEU A CA    1 ? 
ATOM   1481 C C     . LEU A 1 189 ? 4.317   -3.911  43.048 1.00 58.49  ? 191  LEU A C     1 ? 
ATOM   1482 O O     . LEU A 1 189 ? 3.421   -3.908  43.913 1.00 66.97  ? 191  LEU A O     1 ? 
ATOM   1483 C CB    . LEU A 1 189 ? 3.303   -5.145  41.102 1.00 58.56  ? 191  LEU A CB    1 ? 
ATOM   1484 C CG    . LEU A 1 189 ? 3.138   -3.882  40.274 1.00 55.11  ? 191  LEU A CG    1 ? 
ATOM   1485 C CD1   . LEU A 1 189 ? 4.364   -3.621  39.427 1.00 59.67  ? 191  LEU A CD1   1 ? 
ATOM   1486 C CD2   . LEU A 1 189 ? 1.906   -4.021  39.386 1.00 66.27  ? 191  LEU A CD2   1 ? 
ATOM   1487 N N     . HIS A 1 190 ? 5.158   -2.910  42.836 1.00 61.45  ? 192  HIS A N     1 ? 
ATOM   1488 C CA    . HIS A 1 190 ? 5.040   -1.598  43.510 1.00 66.71  ? 192  HIS A CA    1 ? 
ATOM   1489 C C     . HIS A 1 190 ? 4.905   -0.486  42.473 1.00 61.34  ? 192  HIS A C     1 ? 
ATOM   1490 O O     . HIS A 1 190 ? 5.813   -0.322  41.655 1.00 59.51  ? 192  HIS A O     1 ? 
ATOM   1491 C CB    . HIS A 1 190 ? 6.244   -1.375  44.417 1.00 61.73  ? 192  HIS A CB    1 ? 
ATOM   1492 C CG    . HIS A 1 190 ? 6.374   -2.421  45.463 1.00 71.07  ? 192  HIS A CG    1 ? 
ATOM   1493 N ND1   . HIS A 1 190 ? 5.745   -2.313  46.687 1.00 70.43  ? 192  HIS A ND1   1 ? 
ATOM   1494 C CD2   . HIS A 1 190 ? 7.052   -3.591  45.473 1.00 77.75  ? 192  HIS A CD2   1 ? 
ATOM   1495 C CE1   . HIS A 1 190 ? 6.037   -3.375  47.408 1.00 76.09  ? 192  HIS A CE1   1 ? 
ATOM   1496 N NE2   . HIS A 1 190 ? 6.842   -4.175  46.690 1.00 74.46  ? 192  HIS A NE2   1 ? 
ATOM   1497 N N     . VAL A 1 191 ? 3.811   0.247   42.552 1.00 62.05  ? 193  VAL A N     1 ? 
ATOM   1498 C CA    . VAL A 1 191 ? 3.534   1.381   41.653 1.00 59.20  ? 193  VAL A CA    1 ? 
ATOM   1499 C C     . VAL A 1 191 ? 3.827   2.630   42.458 1.00 64.16  ? 193  VAL A C     1 ? 
ATOM   1500 O O     . VAL A 1 191 ? 3.090   2.865   43.447 1.00 61.91  ? 193  VAL A O     1 ? 
ATOM   1501 C CB    . VAL A 1 191 ? 2.099   1.353   41.118 1.00 53.80  ? 193  VAL A CB    1 ? 
ATOM   1502 C CG1   . VAL A 1 191 ? 1.774   2.646   40.377 1.00 58.51  ? 193  VAL A CG1   1 ? 
ATOM   1503 C CG2   . VAL A 1 191 ? 1.908   0.153   40.199 1.00 57.65  ? 193  VAL A CG2   1 ? 
ATOM   1504 N N     . LEU A 1 192 ? 4.854   3.380   42.034 1.00 60.89  ? 194  LEU A N     1 ? 
ATOM   1505 C CA    . LEU A 1 192 ? 5.285   4.613   42.730 1.00 60.03  ? 194  LEU A CA    1 ? 
ATOM   1506 C C     . LEU A 1 192 ? 5.049   5.827   41.845 1.00 54.05  ? 194  LEU A C     1 ? 
ATOM   1507 O O     . LEU A 1 192 ? 5.588   5.864   40.746 1.00 55.87  ? 194  LEU A O     1 ? 
ATOM   1508 C CB    . LEU A 1 192 ? 6.761   4.487   43.064 1.00 58.79  ? 194  LEU A CB    1 ? 
ATOM   1509 C CG    . LEU A 1 192 ? 7.157   3.181   43.744 1.00 58.71  ? 194  LEU A CG    1 ? 
ATOM   1510 C CD1   . LEU A 1 192 ? 8.669   3.151   43.962 1.00 61.46  ? 194  LEU A CD1   1 ? 
ATOM   1511 C CD2   . LEU A 1 192 ? 6.421   3.011   45.065 1.00 54.30  ? 194  LEU A CD2   1 ? 
ATOM   1512 N N     . LYS A 1 193 ? 4.214   6.749   42.318 1.00 56.91  ? 195  LYS A N     1 ? 
ATOM   1513 C CA    . LYS A 1 193 ? 3.863   7.952   41.529 1.00 60.06  ? 195  LYS A CA    1 ? 
ATOM   1514 C C     . LYS A 1 193 ? 4.833   9.089   41.817 1.00 63.50  ? 195  LYS A C     1 ? 
ATOM   1515 O O     . LYS A 1 193 ? 5.027   9.432   42.986 1.00 61.80  ? 195  LYS A O     1 ? 
ATOM   1516 C CB    . LYS A 1 193 ? 2.442   8.447   41.807 1.00 59.24  ? 195  LYS A CB    1 ? 
ATOM   1517 C CG    . LYS A 1 193 ? 1.933   9.489   40.823 1.00 57.72  ? 195  LYS A CG    1 ? 
ATOM   1518 C CD    . LYS A 1 193 ? 0.533   9.967   41.114 1.00 62.96  ? 195  LYS A CD    1 ? 
ATOM   1519 C CE    . LYS A 1 193 ? 0.453   10.822  42.359 1.00 71.22  ? 195  LYS A CE    1 ? 
ATOM   1520 N NZ    . LYS A 1 193 ? 1.303   12.029  42.244 1.00 72.93  ? 195  LYS A NZ    1 ? 
ATOM   1521 N N     . GLN A 1 194 ? 5.419   9.629   40.767 1.00 60.73  ? 196  GLN A N     1 ? 
ATOM   1522 C CA    . GLN A 1 194 ? 6.322   10.788  40.865 1.00 64.33  ? 196  GLN A CA    1 ? 
ATOM   1523 C C     . GLN A 1 194 ? 5.494   12.065  40.922 1.00 68.54  ? 196  GLN A C     1 ? 
ATOM   1524 O O     . GLN A 1 194 ? 4.440   12.147  40.255 1.00 68.20  ? 196  GLN A O     1 ? 
ATOM   1525 C CB    . GLN A 1 194 ? 7.295   10.825  39.684 1.00 69.07  ? 196  GLN A CB    1 ? 
ATOM   1526 C CG    . GLN A 1 194 ? 6.659   11.204  38.352 1.00 61.14  ? 196  GLN A CG    1 ? 
ATOM   1527 C CD    . GLN A 1 194 ? 7.619   10.978  37.212 1.00 70.11  ? 196  GLN A CD    1 ? 
ATOM   1528 O OE1   . GLN A 1 194 ? 7.392   10.145  36.345 1.00 80.59  ? 196  GLN A OE1   1 ? 
ATOM   1529 N NE2   . GLN A 1 194 ? 8.722   11.711  37.206 1.00 75.16  ? 196  GLN A NE2   1 ? 
ATOM   1530 N N     . GLY A 1 195 ? 5.993   13.032  41.687 1.00 67.88  ? 197  GLY A N     1 ? 
ATOM   1531 C CA    . GLY A 1 195 ? 5.305   14.314  41.880 1.00 67.59  ? 197  GLY A CA    1 ? 
ATOM   1532 C C     . GLY A 1 195 ? 5.779   15.305  40.852 1.00 67.33  ? 197  GLY A C     1 ? 
ATOM   1533 O O     . GLY A 1 195 ? 6.965   15.337  40.575 1.00 78.16  ? 197  GLY A O     1 ? 
ATOM   1534 N N     . GLN A 1 196 ? 4.869   16.090  40.309 1.00 70.90  ? 198  GLN A N     1 ? 
ATOM   1535 C CA    . GLN A 1 196 ? 5.239   17.188  39.397 1.00 78.46  ? 198  GLN A CA    1 ? 
ATOM   1536 C C     . GLN A 1 196 ? 5.901   18.300  40.224 1.00 78.14  ? 198  GLN A C     1 ? 
ATOM   1537 O O     . GLN A 1 196 ? 5.700   18.360  41.468 1.00 75.97  ? 198  GLN A O     1 ? 
ATOM   1538 C CB    . GLN A 1 196 ? 4.007   17.657  38.623 1.00 82.64  ? 198  GLN A CB    1 ? 
ATOM   1539 C CG    . GLN A 1 196 ? 3.703   16.793  37.407 1.00 79.62  ? 198  GLN A CG    1 ? 
ATOM   1540 C CD    . GLN A 1 196 ? 2.494   17.276  36.644 1.00 82.85  ? 198  GLN A CD    1 ? 
ATOM   1541 O OE1   . GLN A 1 196 ? 1.384   17.338  37.183 1.00 80.75  ? 198  GLN A OE1   1 ? 
ATOM   1542 N NE2   . GLN A 1 196 ? 2.707   17.632  35.379 1.00 79.06  ? 198  GLN A NE2   1 ? 
ATOM   1543 N N     . VAL A 1 197 ? 6.680   19.133  39.543 1.00 69.28  ? 199  VAL A N     1 ? 
ATOM   1544 C CA    . VAL A 1 197 ? 7.428   20.245  40.183 1.00 65.37  ? 199  VAL A CA    1 ? 
ATOM   1545 C C     . VAL A 1 197 ? 6.964   21.560  39.580 1.00 66.95  ? 199  VAL A C     1 ? 
ATOM   1546 O O     . VAL A 1 197 ? 6.497   21.578  38.428 1.00 73.53  ? 199  VAL A O     1 ? 
ATOM   1547 C CB    . VAL A 1 197 ? 8.943   20.075  40.029 1.00 64.18  ? 199  VAL A CB    1 ? 
ATOM   1548 C CG1   . VAL A 1 197 ? 9.464   18.966  40.927 1.00 69.62  ? 199  VAL A CG1   1 ? 
ATOM   1549 C CG2   . VAL A 1 197 ? 9.322   19.832  38.580 1.00 64.55  ? 199  VAL A CG2   1 ? 
ATOM   1550 N N     . PHE A 1 198 ? 7.136   22.628  40.349 1.00 72.85  ? 200  PHE A N     1 ? 
ATOM   1551 C CA    . PHE A 1 198 ? 6.775   24.009  39.943 1.00 65.01  ? 200  PHE A CA    1 ? 
ATOM   1552 C C     . PHE A 1 198 ? 7.569   24.419  38.715 1.00 58.62  ? 200  PHE A C     1 ? 
ATOM   1553 O O     . PHE A 1 198 ? 8.568   23.764  38.346 1.00 58.49  ? 200  PHE A O     1 ? 
ATOM   1554 C CB    . PHE A 1 198 ? 7.023   24.990  41.079 1.00 65.11  ? 200  PHE A CB    1 ? 
ATOM   1555 C CG    . PHE A 1 198 ? 6.180   24.717  42.293 1.00 67.47  ? 200  PHE A CG    1 ? 
ATOM   1556 C CD1   . PHE A 1 198 ? 4.815   24.557  42.165 1.00 70.68  ? 200  PHE A CD1   1 ? 
ATOM   1557 C CD2   . PHE A 1 198 ? 6.750   24.617  43.551 1.00 67.46  ? 200  PHE A CD2   1 ? 
ATOM   1558 C CE1   . PHE A 1 198 ? 4.031   24.309  43.276 1.00 66.88  ? 200  PHE A CE1   1 ? 
ATOM   1559 C CE2   . PHE A 1 198 ? 5.967   24.377  44.662 1.00 68.54  ? 200  PHE A CE2   1 ? 
ATOM   1560 C CZ    . PHE A 1 198 ? 4.607   24.212  44.521 1.00 69.31  ? 200  PHE A CZ    1 ? 
ATOM   1561 N N     . CYS A 1 199 ? 7.097   25.483  38.087 1.00 60.78  ? 201  CYS A N     1 ? 
ATOM   1562 C CA    . CYS A 1 199 ? 7.662   25.967  36.810 1.00 68.00  ? 201  CYS A CA    1 ? 
ATOM   1563 C C     . CYS A 1 199 ? 8.101   27.420  36.966 1.00 68.13  ? 201  CYS A C     1 ? 
ATOM   1564 O O     . CYS A 1 199 ? 7.569   28.123  37.839 1.00 66.80  ? 201  CYS A O     1 ? 
ATOM   1565 C CB    . CYS A 1 199 ? 6.668   25.818  35.665 1.00 72.81  ? 201  CYS A CB    1 ? 
ATOM   1566 S SG    . CYS A 1 199 ? 6.042   24.132  35.447 1.00 75.32  ? 201  CYS A SG    1 ? 
ATOM   1567 N N     . PHE A 1 200 ? 9.023   27.828  36.100 1.00 71.87  ? 202  PHE A N     1 ? 
ATOM   1568 C CA    . PHE A 1 200 ? 9.612   29.185  36.081 1.00 68.87  ? 202  PHE A CA    1 ? 
ATOM   1569 C C     . PHE A 1 200 ? 9.087   29.970  34.878 1.00 62.70  ? 202  PHE A C     1 ? 
ATOM   1570 O O     . PHE A 1 200 ? 9.376   29.607  33.740 1.00 63.67  ? 202  PHE A O     1 ? 
ATOM   1571 C CB    . PHE A 1 200 ? 11.135  29.094  36.059 1.00 64.96  ? 202  PHE A CB    1 ? 
ATOM   1572 C CG    . PHE A 1 200 ? 11.729  28.412  37.261 1.00 62.39  ? 202  PHE A CG    1 ? 
ATOM   1573 C CD1   . PHE A 1 200 ? 11.314  28.750  38.534 1.00 62.67  ? 202  PHE A CD1   1 ? 
ATOM   1574 C CD2   . PHE A 1 200 ? 12.706  27.440  37.111 1.00 59.30  ? 202  PHE A CD2   1 ? 
ATOM   1575 C CE1   . PHE A 1 200 ? 11.843  28.110  39.635 1.00 63.02  ? 202  PHE A CE1   1 ? 
ATOM   1576 C CE2   . PHE A 1 200 ? 13.221  26.787  38.216 1.00 63.59  ? 202  PHE A CE2   1 ? 
ATOM   1577 C CZ    . PHE A 1 200 ? 12.791  27.129  39.473 1.00 65.37  ? 202  PHE A CZ    1 ? 
ATOM   1578 N N     . ALA A 1 201 ? 8.380   31.063  35.140 1.00 64.29  ? 203  ALA A N     1 ? 
ATOM   1579 C CA    . ALA A 1 201 ? 7.809   31.910  34.078 1.00 63.55  ? 203  ALA A CA    1 ? 
ATOM   1580 C C     . ALA A 1 201 ? 8.920   32.653  33.346 1.00 71.76  ? 203  ALA A C     1 ? 
ATOM   1581 O O     . ALA A 1 201 ? 8.703   32.982  32.160 1.00 75.24  ? 203  ALA A O     1 ? 
ATOM   1582 C CB    . ALA A 1 201 ? 6.810   32.873  34.654 1.00 63.10  ? 203  ALA A CB    1 ? 
ATOM   1583 N N     . ASP A 1 202 ? 10.040  32.923  34.020 1.00 69.86  ? 204  ASP A N     1 ? 
ATOM   1584 C CA    . ASP A 1 202 ? 11.127  33.736  33.416 1.00 77.08  ? 204  ASP A CA    1 ? 
ATOM   1585 C C     . ASP A 1 202 ? 12.487  33.225  33.887 1.00 76.20  ? 204  ASP A C     1 ? 
ATOM   1586 O O     . ASP A 1 202 ? 12.555  32.313  34.750 1.00 76.48  ? 204  ASP A O     1 ? 
ATOM   1587 C CB    . ASP A 1 202 ? 10.957  35.224  33.732 1.00 67.80  ? 204  ASP A CB    1 ? 
ATOM   1588 C CG    . ASP A 1 202 ? 10.929  35.518  35.218 1.00 68.65  ? 204  ASP A CG    1 ? 
ATOM   1589 O OD1   . ASP A 1 202 ? 11.521  34.715  36.003 1.00 70.46  ? 204  ASP A OD1   1 ? 
ATOM   1590 O OD2   . ASP A 1 202 ? 10.334  36.558  35.585 1.00 73.70  ? 204  ASP A OD2   1 ? 
ATOM   1591 N N     . SER A 1 203 ? 13.531  33.832  33.345 1.00 64.47  ? 205  SER A N     1 ? 
ATOM   1592 C CA    . SER A 1 203 ? 14.932  33.446  33.622 1.00 67.91  ? 205  SER A CA    1 ? 
ATOM   1593 C C     . SER A 1 203 ? 15.346  33.819  35.046 1.00 64.18  ? 205  SER A C     1 ? 
ATOM   1594 O O     . SER A 1 203 ? 16.449  33.419  35.449 1.00 75.85  ? 205  SER A O     1 ? 
ATOM   1595 C CB    . SER A 1 203 ? 15.845  34.084  32.628 1.00 73.38  ? 205  SER A CB    1 ? 
ATOM   1596 O OG    . SER A 1 203 ? 15.400  35.403  32.347 1.00 73.36  ? 205  SER A OG    1 ? 
ATOM   1597 N N     . ALA A 1 204 ? 14.526  34.562  35.777 1.00 65.95  ? 206  ALA A N     1 ? 
ATOM   1598 C CA    . ALA A 1 204 ? 14.806  34.937  37.187 1.00 63.61  ? 206  ALA A CA    1 ? 
ATOM   1599 C C     . ALA A 1 204 ? 14.164  33.948  38.160 1.00 64.54  ? 206  ALA A C     1 ? 
ATOM   1600 O O     . ALA A 1 204 ? 14.135  34.263  39.354 1.00 67.17  ? 206  ALA A O     1 ? 
ATOM   1601 C CB    . ALA A 1 204 ? 14.307  36.333  37.460 1.00 60.47  ? 206  ALA A CB    1 ? 
ATOM   1602 N N     . ALA A 1 205 ? 13.643  32.820  37.663 1.00 69.15  ? 207  ALA A N     1 ? 
ATOM   1603 C CA    . ALA A 1 205 ? 13.068  31.722  38.473 1.00 61.61  ? 207  ALA A CA    1 ? 
ATOM   1604 C C     . ALA A 1 205 ? 11.822  32.219  39.210 1.00 58.40  ? 207  ALA A C     1 ? 
ATOM   1605 O O     . ALA A 1 205 ? 11.592  31.830  40.357 1.00 57.08  ? 207  ALA A O     1 ? 
ATOM   1606 C CB    . ALA A 1 205 ? 14.111  31.182  39.428 1.00 64.50  ? 207  ALA A CB    1 ? 
ATOM   1607 N N     . HIS A 1 206 ? 11.033  33.053  38.549 1.00 64.76  ? 208  HIS A N     1 ? 
ATOM   1608 C CA    . HIS A 1 206 ? 9.713   33.491  39.074 1.00 70.83  ? 208  HIS A CA    1 ? 
ATOM   1609 C C     . HIS A 1 206 ? 8.687   32.385  38.813 1.00 70.10  ? 208  HIS A C     1 ? 
ATOM   1610 O O     . HIS A 1 206 ? 8.488   32.042  37.626 1.00 69.81  ? 208  HIS A O     1 ? 
ATOM   1611 C CB    . HIS A 1 206 ? 9.277   34.817  38.441 1.00 67.19  ? 208  HIS A CB    1 ? 
ATOM   1612 C CG    . HIS A 1 206 ? 10.062  35.982  38.930 1.00 68.15  ? 208  HIS A CG    1 ? 
ATOM   1613 N ND1   . HIS A 1 206 ? 10.872  36.735  38.103 1.00 65.67  ? 208  HIS A ND1   1 ? 
ATOM   1614 C CD2   . HIS A 1 206 ? 10.188  36.505  40.167 1.00 69.03  ? 208  HIS A CD2   1 ? 
ATOM   1615 C CE1   . HIS A 1 206 ? 11.468  37.670  38.814 1.00 69.87  ? 208  HIS A CE1   1 ? 
ATOM   1616 N NE2   . HIS A 1 206 ? 11.067  37.554  40.083 1.00 69.18  ? 208  HIS A NE2   1 ? 
ATOM   1617 N N     . LEU A 1 207 ? 8.078   31.854  39.871 1.00 67.16  ? 209  LEU A N     1 ? 
ATOM   1618 C CA    . LEU A 1 207 ? 7.168   30.687  39.758 1.00 71.07  ? 209  LEU A CA    1 ? 
ATOM   1619 C C     . LEU A 1 207 ? 5.989   31.058  38.865 1.00 67.76  ? 209  LEU A C     1 ? 
ATOM   1620 O O     . LEU A 1 207 ? 5.404   32.119  39.072 1.00 74.63  ? 209  LEU A O     1 ? 
ATOM   1621 C CB    . LEU A 1 207 ? 6.677   30.249  41.139 1.00 66.86  ? 209  LEU A CB    1 ? 
ATOM   1622 C CG    . LEU A 1 207 ? 7.762   29.708  42.055 1.00 65.88  ? 209  LEU A CG    1 ? 
ATOM   1623 C CD1   . LEU A 1 207 ? 7.263   29.610  43.478 1.00 73.61  ? 209  LEU A CD1   1 ? 
ATOM   1624 C CD2   . LEU A 1 207 ? 8.245   28.372  41.568 1.00 65.88  ? 209  LEU A CD2   1 ? 
ATOM   1625 N N     . ALA A 1 208 ? 5.669   30.189  37.917 1.00 68.70  ? 210  ALA A N     1 ? 
ATOM   1626 C CA    . ALA A 1 208 ? 4.578   30.423  36.949 1.00 75.28  ? 210  ALA A CA    1 ? 
ATOM   1627 C C     . ALA A 1 208 ? 3.217   30.034  37.538 1.00 69.55  ? 210  ALA A C     1 ? 
ATOM   1628 O O     . ALA A 1 208 ? 3.122   29.113  38.372 1.00 62.52  ? 210  ALA A O     1 ? 
ATOM   1629 C CB    . ALA A 1 208 ? 4.849   29.687  35.669 1.00 74.47  ? 210  ALA A CB    1 ? 
ATOM   1630 N N     . LEU A 1 209 ? 2.187   30.759  37.115 1.00 79.62  ? 211  LEU A N     1 ? 
ATOM   1631 C CA    . LEU A 1 209 ? 0.786   30.438  37.466 1.00 80.99  ? 211  LEU A CA    1 ? 
ATOM   1632 C C     . LEU A 1 209 ? 0.039   30.014  36.202 1.00 82.96  ? 211  LEU A C     1 ? 
ATOM   1633 O O     . LEU A 1 209 ? 0.410   30.443  35.103 1.00 81.37  ? 211  LEU A O     1 ? 
ATOM   1634 C CB    . LEU A 1 209 ? 0.133   31.648  38.122 1.00 77.99  ? 211  LEU A CB    1 ? 
ATOM   1635 C CG    . LEU A 1 209 ? 0.697   32.039  39.482 1.00 80.12  ? 211  LEU A CG    1 ? 
ATOM   1636 C CD1   . LEU A 1 209 ? 0.168   33.410  39.878 1.00 91.37  ? 211  LEU A CD1   1 ? 
ATOM   1637 C CD2   . LEU A 1 209 ? 0.371   31.012  40.550 1.00 70.49  ? 211  LEU A CD2   1 ? 
ATOM   1638 N N     . ASP A 1 210 ? -0.965  29.166  36.365 1.00 96.25  ? 212  ASP A N     1 ? 
ATOM   1639 C CA    . ASP A 1 210 ? -1.794  28.694  35.231 1.00 97.20  ? 212  ASP A CA    1 ? 
ATOM   1640 C C     . ASP A 1 210 ? -2.934  29.687  35.025 1.00 96.85  ? 212  ASP A C     1 ? 
ATOM   1641 O O     . ASP A 1 210 ? -2.922  30.774  35.655 1.00 94.27  ? 212  ASP A O     1 ? 
ATOM   1642 C CB    . ASP A 1 210 ? -2.294  27.266  35.461 1.00 98.43  ? 212  ASP A CB    1 ? 
ATOM   1643 C CG    . ASP A 1 210 ? -3.220  27.106  36.662 1.00 104.57 ? 212  ASP A CG    1 ? 
ATOM   1644 O OD1   . ASP A 1 210 ? -3.589  28.138  37.273 1.00 114.41 ? 212  ASP A OD1   1 ? 
ATOM   1645 O OD2   . ASP A 1 210 ? -3.572  25.955  36.974 1.00 94.45  ? 212  ASP A OD2   1 ? 
ATOM   1646 N N     . GLU A 1 211 ? -3.892  29.302  34.189 1.00 101.17 ? 213  GLU A N     1 ? 
ATOM   1647 C CA    . GLU A 1 211 ? -4.994  30.193  33.750 1.00 104.93 ? 213  GLU A CA    1 ? 
ATOM   1648 C C     . GLU A 1 211 ? -5.892  30.517  34.949 1.00 99.45  ? 213  GLU A C     1 ? 
ATOM   1649 O O     . GLU A 1 211 ? -6.550  31.565  34.907 1.00 102.05 ? 213  GLU A O     1 ? 
ATOM   1650 C CB    . GLU A 1 211 ? -5.806  29.571  32.608 1.00 106.51 ? 213  GLU A CB    1 ? 
ATOM   1651 C CG    . GLU A 1 211 ? -4.996  28.699  31.652 1.00 107.78 ? 213  GLU A CG    1 ? 
ATOM   1652 C CD    . GLU A 1 211 ? -4.610  27.338  32.230 1.00 113.74 ? 213  GLU A CD    1 ? 
ATOM   1653 O OE1   . GLU A 1 211 ? -3.534  26.808  31.849 1.00 103.46 ? 213  GLU A OE1   1 ? 
ATOM   1654 O OE2   . GLU A 1 211 ? -5.372  26.824  33.098 1.00 113.78 ? 213  GLU A OE2   1 ? 
ATOM   1655 N N     . THR A 1 212 ? -5.899  29.674  35.982 1.00 91.45  ? 214  THR A N     1 ? 
ATOM   1656 C CA    . THR A 1 212 ? -6.806  29.844  37.145 1.00 87.34  ? 214  THR A CA    1 ? 
ATOM   1657 C C     . THR A 1 212 ? -6.050  30.387  38.357 1.00 86.62  ? 214  THR A C     1 ? 
ATOM   1658 O O     . THR A 1 212 ? -6.573  30.275  39.473 1.00 84.14  ? 214  THR A O     1 ? 
ATOM   1659 C CB    . THR A 1 212 ? -7.493  28.520  37.487 1.00 90.22  ? 214  THR A CB    1 ? 
ATOM   1660 O OG1   . THR A 1 212 ? -8.062  28.587  38.794 1.00 104.44 ? 214  THR A OG1   1 ? 
ATOM   1661 C CG2   . THR A 1 212 ? -6.530  27.357  37.476 1.00 93.11  ? 214  THR A CG2   1 ? 
ATOM   1662 N N     . GLY A 1 213 ? -4.870  30.966  38.162 1.00 91.76  ? 215  GLY A N     1 ? 
ATOM   1663 C CA    . GLY A 1 213 ? -4.105  31.561  39.276 1.00 87.81  ? 215  GLY A CA    1 ? 
ATOM   1664 C C     . GLY A 1 213 ? -3.541  30.505  40.209 1.00 81.84  ? 215  GLY A C     1 ? 
ATOM   1665 O O     . GLY A 1 213 ? -3.301  30.829  41.386 1.00 74.72  ? 215  GLY A O     1 ? 
ATOM   1666 N N     . LYS A 1 214 ? -3.317  29.293  39.703 1.00 87.56  ? 216  LYS A N     1 ? 
ATOM   1667 C CA    . LYS A 1 214 ? -2.713  28.190  40.491 1.00 93.55  ? 216  LYS A CA    1 ? 
ATOM   1668 C C     . LYS A 1 214 ? -1.301  27.927  39.973 1.00 84.46  ? 216  LYS A C     1 ? 
ATOM   1669 O O     . LYS A 1 214 ? -1.009  28.234  38.808 1.00 90.18  ? 216  LYS A O     1 ? 
ATOM   1670 C CB    . LYS A 1 214 ? -3.577  26.928  40.429 1.00 105.26 ? 216  LYS A CB    1 ? 
ATOM   1671 C CG    . LYS A 1 214 ? -4.987  27.109  40.974 1.00 109.96 ? 216  LYS A CG    1 ? 
ATOM   1672 C CD    . LYS A 1 214 ? -5.775  25.824  41.028 1.00 110.49 ? 216  LYS A CD    1 ? 
ATOM   1673 C CE    . LYS A 1 214 ? -7.153  26.035  41.617 1.00 112.06 ? 216  LYS A CE    1 ? 
ATOM   1674 N NZ    . LYS A 1 214 ? -7.795  24.749  41.980 1.00 111.06 ? 216  LYS A NZ    1 ? 
ATOM   1675 N N     . LEU A 1 215 ? -0.455  27.382  40.832 1.00 76.42  ? 217  LEU A N     1 ? 
ATOM   1676 C CA    . LEU A 1 215 ? 0.959   27.126  40.485 1.00 77.44  ? 217  LEU A CA    1 ? 
ATOM   1677 C C     . LEU A 1 215 ? 1.040   26.051  39.407 1.00 77.09  ? 217  LEU A C     1 ? 
ATOM   1678 O O     . LEU A 1 215 ? 0.586   24.924  39.637 1.00 82.82  ? 217  LEU A O     1 ? 
ATOM   1679 C CB    . LEU A 1 215 ? 1.724   26.722  41.741 1.00 76.95  ? 217  LEU A CB    1 ? 
ATOM   1680 C CG    . LEU A 1 215 ? 1.971   27.872  42.710 1.00 81.71  ? 217  LEU A CG    1 ? 
ATOM   1681 C CD1   . LEU A 1 215 ? 2.483   27.355  44.039 1.00 82.65  ? 217  LEU A CD1   1 ? 
ATOM   1682 C CD2   . LEU A 1 215 ? 2.946   28.878  42.116 1.00 77.80  ? 217  LEU A CD2   1 ? 
ATOM   1683 N N     . LEU A 1 216 ? 1.611   26.401  38.266 1.00 72.34  ? 218  LEU A N     1 ? 
ATOM   1684 C CA    . LEU A 1 216 ? 1.784   25.443  37.159 1.00 68.96  ? 218  LEU A CA    1 ? 
ATOM   1685 C C     . LEU A 1 216 ? 2.751   24.349  37.591 1.00 72.78  ? 218  LEU A C     1 ? 
ATOM   1686 O O     . LEU A 1 216 ? 3.715   24.643  38.318 1.00 81.59  ? 218  LEU A O     1 ? 
ATOM   1687 C CB    . LEU A 1 216 ? 2.301   26.180  35.926 1.00 70.71  ? 218  LEU A CB    1 ? 
ATOM   1688 C CG    . LEU A 1 216 ? 2.363   25.352  34.648 1.00 79.16  ? 218  LEU A CG    1 ? 
ATOM   1689 C CD1   . LEU A 1 216 ? 0.986   24.825  34.254 1.00 84.46  ? 218  LEU A CD1   1 ? 
ATOM   1690 C CD2   . LEU A 1 216 ? 2.946   26.180  33.522 1.00 77.14  ? 218  LEU A CD2   1 ? 
ATOM   1691 N N     . ARG A 1 217 ? 2.478   23.123  37.159 1.00 73.23  ? 219  ARG A N     1 ? 
ATOM   1692 C CA    . ARG A 1 217 ? 3.335   21.968  37.497 1.00 71.66  ? 219  ARG A CA    1 ? 
ATOM   1693 C C     . ARG A 1 217 ? 3.664   21.211  36.220 1.00 69.14  ? 219  ARG A C     1 ? 
ATOM   1694 O O     . ARG A 1 217 ? 2.857   21.215  35.277 1.00 73.26  ? 219  ARG A O     1 ? 
ATOM   1695 C CB    . ARG A 1 217 ? 2.660   21.076  38.538 1.00 70.21  ? 219  ARG A CB    1 ? 
ATOM   1696 C CG    . ARG A 1 217 ? 2.797   21.588  39.963 1.00 71.96  ? 219  ARG A CG    1 ? 
ATOM   1697 C CD    . ARG A 1 217 ? 2.113   20.672  40.936 1.00 77.50  ? 219  ARG A CD    1 ? 
ATOM   1698 N NE    . ARG A 1 217 ? 2.081   21.209  42.289 1.00 71.88  ? 219  ARG A NE    1 ? 
ATOM   1699 C CZ    . ARG A 1 217 ? 2.829   20.784  43.300 1.00 66.58  ? 219  ARG A CZ    1 ? 
ATOM   1700 N NH1   . ARG A 1 217 ? 3.746   19.852  43.125 1.00 68.46  ? 219  ARG A NH1   1 ? 
ATOM   1701 N NH2   . ARG A 1 217 ? 2.656   21.298  44.499 1.00 71.93  ? 219  ARG A NH2   1 ? 
ATOM   1702 N N     . LYS A 1 218 ? 4.841   20.601  36.218 1.00 70.95  ? 220  LYS A N     1 ? 
ATOM   1703 C CA    . LYS A 1 218 ? 5.371   19.855  35.056 1.00 69.31  ? 220  LYS A CA    1 ? 
ATOM   1704 C C     . LYS A 1 218 ? 6.271   18.738  35.554 1.00 67.65  ? 220  LYS A C     1 ? 
ATOM   1705 O O     . LYS A 1 218 ? 6.735   18.738  36.693 1.00 67.02  ? 220  LYS A O     1 ? 
ATOM   1706 C CB    . LYS A 1 218 ? 6.104   20.787  34.102 1.00 65.36  ? 220  LYS A CB    1 ? 
ATOM   1707 C CG    . LYS A 1 218 ? 5.203   21.638  33.219 1.00 71.20  ? 220  LYS A CG    1 ? 
ATOM   1708 C CD    . LYS A 1 218 ? 5.977   22.426  32.193 1.00 73.36  ? 220  LYS A CD    1 ? 
ATOM   1709 C CE    . LYS A 1 218 ? 5.086   23.180  31.232 1.00 82.93  ? 220  LYS A CE    1 ? 
ATOM   1710 N NZ    . LYS A 1 218 ? 5.873   23.993  30.266 1.00 84.33  ? 220  LYS A NZ    1 ? 
ATOM   1711 N N     . PRO A 1 219 ? 6.490   17.704  34.726 1.00 79.10  ? 221  PRO A N     1 ? 
ATOM   1712 C CA    . PRO A 1 219 ? 7.264   16.553  35.170 1.00 77.44  ? 221  PRO A CA    1 ? 
ATOM   1713 C C     . PRO A 1 219 ? 8.717   16.916  35.484 1.00 73.10  ? 221  PRO A C     1 ? 
ATOM   1714 O O     . PRO A 1 219 ? 9.290   17.748  34.808 1.00 70.51  ? 221  PRO A O     1 ? 
ATOM   1715 C CB    . PRO A 1 219 ? 7.226   15.591  33.974 1.00 83.55  ? 221  PRO A CB    1 ? 
ATOM   1716 C CG    . PRO A 1 219 ? 6.019   16.041  33.168 1.00 82.45  ? 221  PRO A CG    1 ? 
ATOM   1717 C CD    . PRO A 1 219 ? 5.957   17.539  33.357 1.00 82.67  ? 221  PRO A CD    1 ? 
ATOM   1718 N N     . HIS A 1 220 ? 9.274   16.231  36.476 1.00 69.82  ? 222  HIS A N     1 ? 
ATOM   1719 C CA    . HIS A 1 220 ? 10.675  16.396  36.921 1.00 67.17  ? 222  HIS A CA    1 ? 
ATOM   1720 C C     . HIS A 1 220 ? 11.600  15.428  36.172 1.00 70.81  ? 222  HIS A C     1 ? 
ATOM   1721 O O     . HIS A 1 220 ? 12.807  15.447  36.444 1.00 69.94  ? 222  HIS A O     1 ? 
ATOM   1722 C CB    . HIS A 1 220 ? 10.765  16.175  38.427 1.00 73.53  ? 222  HIS A CB    1 ? 
ATOM   1723 C CG    . HIS A 1 220 ? 12.082  16.571  38.991 1.00 71.47  ? 222  HIS A CG    1 ? 
ATOM   1724 N ND1   . HIS A 1 220 ? 12.954  15.663  39.532 1.00 72.53  ? 222  HIS A ND1   1 ? 
ATOM   1725 C CD2   . HIS A 1 220 ? 12.694  17.772  39.059 1.00 73.60  ? 222  HIS A CD2   1 ? 
ATOM   1726 C CE1   . HIS A 1 220 ? 14.044  16.297  39.938 1.00 73.96  ? 222  HIS A CE1   1 ? 
ATOM   1727 N NE2   . HIS A 1 220 ? 13.903  17.587  39.662 1.00 68.73  ? 222  HIS A NE2   1 ? 
ATOM   1728 N N     . GLY A 1 221 ? 11.072  14.579  35.296 1.00 65.09  ? 223  GLY A N     1 ? 
ATOM   1729 C CA    . GLY A 1 221 ? 11.906  13.651  34.511 1.00 67.28  ? 223  GLY A CA    1 ? 
ATOM   1730 C C     . GLY A 1 221 ? 11.968  12.254  35.118 1.00 66.70  ? 223  GLY A C     1 ? 
ATOM   1731 O O     . GLY A 1 221 ? 11.534  12.028  36.264 1.00 68.43  ? 223  GLY A O     1 ? 
ATOM   1732 N N     . HIS A 1 222 ? 12.534  11.335  34.367 1.00 64.10  ? 224  HIS A N     1 ? 
ATOM   1733 C CA    . HIS A 1 222 ? 12.584  9.913   34.764 1.00 65.99  ? 224  HIS A CA    1 ? 
ATOM   1734 C C     . HIS A 1 222 ? 13.691  9.669   35.793 1.00 62.24  ? 224  HIS A C     1 ? 
ATOM   1735 O O     . HIS A 1 222 ? 13.814  8.541   36.231 1.00 60.82  ? 224  HIS A O     1 ? 
ATOM   1736 C CB    . HIS A 1 222 ? 12.718  9.027   33.525 1.00 62.90  ? 224  HIS A CB    1 ? 
ATOM   1737 C CG    . HIS A 1 222 ? 13.746  9.467   32.537 1.00 60.84  ? 224  HIS A CG    1 ? 
ATOM   1738 N ND1   . HIS A 1 222 ? 15.100  9.342   32.770 1.00 63.20  ? 224  HIS A ND1   1 ? 
ATOM   1739 C CD2   . HIS A 1 222 ? 13.624  9.972   31.295 1.00 60.33  ? 224  HIS A CD2   1 ? 
ATOM   1740 C CE1   . HIS A 1 222 ? 15.774  9.765   31.723 1.00 60.35  ? 224  HIS A CE1   1 ? 
ATOM   1741 N NE2   . HIS A 1 222 ? 14.889  10.148  30.792 1.00 64.45  ? 224  HIS A NE2   1 ? 
ATOM   1742 N N     . GLY A 1 223 ? 14.452  10.695  36.187 1.00 69.43  ? 225  GLY A N     1 ? 
ATOM   1743 C CA    . GLY A 1 223 ? 15.453  10.567  37.271 1.00 62.01  ? 225  GLY A CA    1 ? 
ATOM   1744 C C     . GLY A 1 223 ? 14.819  10.429  38.644 1.00 62.85  ? 225  GLY A C     1 ? 
ATOM   1745 O O     . GLY A 1 223 ? 15.548  10.102  39.585 1.00 67.37  ? 225  GLY A O     1 ? 
ATOM   1746 N N     . ASP A 1 224 ? 13.495  10.573  38.742 1.00 74.10  ? 226  ASP A N     1 ? 
ATOM   1747 C CA    . ASP A 1 224 ? 12.732  10.481  40.016 1.00 64.32  ? 226  ASP A CA    1 ? 
ATOM   1748 C C     . ASP A 1 224 ? 12.650  9.050   40.569 1.00 68.34  ? 226  ASP A C     1 ? 
ATOM   1749 O O     . ASP A 1 224 ? 12.265  8.939   41.743 1.00 65.57  ? 226  ASP A O     1 ? 
ATOM   1750 C CB    . ASP A 1 224 ? 11.330  11.034  39.812 1.00 62.25  ? 226  ASP A CB    1 ? 
ATOM   1751 C CG    . ASP A 1 224 ? 11.324  12.543  39.675 1.00 67.93  ? 226  ASP A CG    1 ? 
ATOM   1752 O OD1   . ASP A 1 224 ? 12.403  13.138  39.881 1.00 76.79  ? 226  ASP A OD1   1 ? 
ATOM   1753 O OD2   . ASP A 1 224 ? 10.236  13.127  39.382 1.00 62.37  ? 226  ASP A OD2   1 ? 
ATOM   1754 N N     . VAL A 1 225 ? 12.972  8.020   39.780 1.00 66.07  ? 227  VAL A N     1 ? 
ATOM   1755 C CA    . VAL A 1 225 ? 12.813  6.599   40.218 1.00 75.45  ? 227  VAL A CA    1 ? 
ATOM   1756 C C     . VAL A 1 225 ? 13.616  6.353   41.475 1.00 63.92  ? 227  VAL A C     1 ? 
ATOM   1757 O O     . VAL A 1 225 ? 13.046  5.746   42.390 1.00 76.32  ? 227  VAL A O     1 ? 
ATOM   1758 C CB    . VAL A 1 225 ? 13.228  5.584   39.140 1.00 73.83  ? 227  VAL A CB    1 ? 
ATOM   1759 C CG1   . VAL A 1 225 ? 12.076  5.297   38.220 1.00 73.43  ? 227  VAL A CG1   1 ? 
ATOM   1760 C CG2   . VAL A 1 225 ? 14.445  6.042   38.361 1.00 66.45  ? 227  VAL A CG2   1 ? 
ATOM   1761 N N     . HIS A 1 226 ? 14.871  6.802   41.491 1.00 69.91  ? 228  HIS A N     1 ? 
ATOM   1762 C CA    . HIS A 1 226 ? 15.845  6.435   42.560 1.00 66.55  ? 228  HIS A CA    1 ? 
ATOM   1763 C C     . HIS A 1 226 ? 15.341  6.925   43.904 1.00 61.85  ? 228  HIS A C     1 ? 
ATOM   1764 O O     . HIS A 1 226 ? 15.208  6.101   44.800 1.00 71.52  ? 228  HIS A O     1 ? 
ATOM   1765 C CB    . HIS A 1 226 ? 17.214  6.961   42.207 1.00 64.08  ? 228  HIS A CB    1 ? 
ATOM   1766 C CG    . HIS A 1 226 ? 17.625  6.558   40.831 1.00 62.88  ? 228  HIS A CG    1 ? 
ATOM   1767 N ND1   . HIS A 1 226 ? 17.753  5.236   40.443 1.00 62.44  ? 228  HIS A ND1   1 ? 
ATOM   1768 C CD2   . HIS A 1 226 ? 17.903  7.293   39.738 1.00 64.37  ? 228  HIS A CD2   1 ? 
ATOM   1769 C CE1   . HIS A 1 226 ? 18.134  5.171   39.187 1.00 58.32  ? 228  HIS A CE1   1 ? 
ATOM   1770 N NE2   . HIS A 1 226 ? 18.228  6.426   38.715 1.00 60.51  ? 228  HIS A NE2   1 ? 
ATOM   1771 N N     . SER A 1 227 ? 14.974  8.195   43.989 1.00 63.57  ? 229  SER A N     1 ? 
ATOM   1772 C CA    . SER A 1 227 ? 14.415  8.775   45.233 1.00 70.92  ? 229  SER A CA    1 ? 
ATOM   1773 C C     . SER A 1 227 ? 13.126  8.040   45.585 1.00 66.17  ? 229  SER A C     1 ? 
ATOM   1774 O O     . SER A 1 227 ? 12.929  7.700   46.783 1.00 70.75  ? 229  SER A O     1 ? 
ATOM   1775 C CB    . SER A 1 227 ? 14.181  10.251  45.101 1.00 72.57  ? 229  SER A CB    1 ? 
ATOM   1776 O OG    . SER A 1 227 ? 13.667  10.561  43.810 1.00 83.76  ? 229  SER A OG    1 ? 
ATOM   1777 N N     . LEU A 1 228 ? 12.288  7.783   44.585 1.00 67.29  ? 230  LEU A N     1 ? 
ATOM   1778 C CA    . LEU A 1 228 ? 11.024  7.032   44.815 1.00 62.52  ? 230  LEU A CA    1 ? 
ATOM   1779 C C     . LEU A 1 228 ? 11.346  5.640   45.353 1.00 61.80  ? 230  LEU A C     1 ? 
ATOM   1780 O O     . LEU A 1 228 ? 10.627  5.196   46.270 1.00 63.32  ? 230  LEU A O     1 ? 
ATOM   1781 C CB    . LEU A 1 228 ? 10.224  6.938   43.523 1.00 59.51  ? 230  LEU A CB    1 ? 
ATOM   1782 C CG    . LEU A 1 228 ? 9.438   8.184   43.140 1.00 58.13  ? 230  LEU A CG    1 ? 
ATOM   1783 C CD1   . LEU A 1 228 ? 8.679   7.931   41.846 1.00 57.82  ? 230  LEU A CD1   1 ? 
ATOM   1784 C CD2   . LEU A 1 228 ? 8.494   8.603   44.248 1.00 58.48  ? 230  LEU A CD2   1 ? 
ATOM   1785 N N     . ILE A 1 229 ? 12.394  5.009   44.835 1.00 63.62  ? 231  ILE A N     1 ? 
ATOM   1786 C CA    . ILE A 1 229 ? 12.850  3.683   45.342 1.00 66.94  ? 231  ILE A CA    1 ? 
ATOM   1787 C C     . ILE A 1 229 ? 13.419  3.854   46.760 1.00 71.47  ? 231  ILE A C     1 ? 
ATOM   1788 O O     . ILE A 1 229 ? 13.153  2.983   47.611 1.00 73.16  ? 231  ILE A O     1 ? 
ATOM   1789 C CB    . ILE A 1 229 ? 13.843  3.024   44.366 1.00 64.75  ? 231  ILE A CB    1 ? 
ATOM   1790 C CG1   . ILE A 1 229 ? 13.134  2.647   43.064 1.00 62.53  ? 231  ILE A CG1   1 ? 
ATOM   1791 C CG2   . ILE A 1 229 ? 14.516  1.813   44.991 1.00 66.00  ? 231  ILE A CG2   1 ? 
ATOM   1792 C CD1   . ILE A 1 229 ? 14.006  1.899   42.081 1.00 63.23  ? 231  ILE A CD1   1 ? 
ATOM   1793 N N     . TYR A 1 230 ? 14.163  4.931   47.012 1.00 77.38  ? 232  TYR A N     1 ? 
ATOM   1794 C CA    . TYR A 1 230 ? 14.867  5.133   48.302 1.00 74.37  ? 232  TYR A CA    1 ? 
ATOM   1795 C C     . TYR A 1 230 ? 13.849  5.245   49.436 1.00 63.56  ? 232  TYR A C     1 ? 
ATOM   1796 O O     . TYR A 1 230 ? 14.101  4.696   50.492 1.00 74.61  ? 232  TYR A O     1 ? 
ATOM   1797 C CB    . TYR A 1 230 ? 15.777  6.360   48.254 1.00 82.48  ? 232  TYR A CB    1 ? 
ATOM   1798 C CG    . TYR A 1 230 ? 16.332  6.729   49.605 1.00 82.11  ? 232  TYR A CG    1 ? 
ATOM   1799 C CD1   . TYR A 1 230 ? 17.318  5.959   50.202 1.00 83.48  ? 232  TYR A CD1   1 ? 
ATOM   1800 C CD2   . TYR A 1 230 ? 15.843  7.824   50.302 1.00 86.25  ? 232  TYR A CD2   1 ? 
ATOM   1801 C CE1   . TYR A 1 230 ? 17.821  6.281   51.454 1.00 91.00  ? 232  TYR A CE1   1 ? 
ATOM   1802 C CE2   . TYR A 1 230 ? 16.333  8.163   51.551 1.00 89.84  ? 232  TYR A CE2   1 ? 
ATOM   1803 C CZ    . TYR A 1 230 ? 17.321  7.387   52.131 1.00 93.21  ? 232  TYR A CZ    1 ? 
ATOM   1804 O OH    . TYR A 1 230 ? 17.809  7.744   53.354 1.00 90.40  ? 232  TYR A OH    1 ? 
ATOM   1805 N N     . ASN A 1 231 ? 12.735  5.926   49.201 1.00 66.31  ? 233  ASN A N     1 ? 
ATOM   1806 C CA    . ASN A 1 231 ? 11.705  6.199   50.232 1.00 70.11  ? 233  ASN A CA    1 ? 
ATOM   1807 C C     . ASN A 1 231 ? 10.605  5.128   50.230 1.00 75.83  ? 233  ASN A C     1 ? 
ATOM   1808 O O     . ASN A 1 231 ? 9.647   5.242   51.032 1.00 75.01  ? 233  ASN A O     1 ? 
ATOM   1809 C CB    . ASN A 1 231 ? 11.120  7.596   50.040 1.00 73.19  ? 233  ASN A CB    1 ? 
ATOM   1810 C CG    . ASN A 1 231 ? 12.108  8.669   50.445 1.00 78.07  ? 233  ASN A CG    1 ? 
ATOM   1811 O OD1   . ASN A 1 231 ? 12.294  8.920   51.632 1.00 88.71  ? 233  ASN A OD1   1 ? 
ATOM   1812 N ND2   . ASN A 1 231 ? 12.772  9.275   49.478 1.00 73.79  ? 233  ASN A ND2   1 ? 
ATOM   1813 N N     . ALA A 1 232 ? 10.718  4.108   49.387 1.00 77.06  ? 234  ALA A N     1 ? 
ATOM   1814 C CA    . ALA A 1 232 ? 9.666   3.077   49.271 1.00 80.39  ? 234  ALA A CA    1 ? 
ATOM   1815 C C     . ALA A 1 232 ? 9.808   2.076   50.414 1.00 75.73  ? 234  ALA A C     1 ? 
ATOM   1816 O O     . ALA A 1 232 ? 10.912  1.599   50.672 1.00 74.38  ? 234  ALA A O     1 ? 
ATOM   1817 C CB    . ALA A 1 232 ? 9.732   2.388   47.937 1.00 82.04  ? 234  ALA A CB    1 ? 
ATOM   1818 N N     . THR A 1 233 ? 8.693   1.733   51.031 1.00 76.12  ? 235  THR A N     1 ? 
ATOM   1819 C CA    . THR A 1 233 ? 8.663   0.740   52.121 1.00 82.54  ? 235  THR A CA    1 ? 
ATOM   1820 C C     . THR A 1 233 ? 7.690   -0.372  51.776 1.00 87.87  ? 235  THR A C     1 ? 
ATOM   1821 O O     . THR A 1 233 ? 6.811   -0.175  50.934 1.00 90.76  ? 235  THR A O     1 ? 
ATOM   1822 C CB    . THR A 1 233 ? 8.314   1.396   53.456 1.00 84.93  ? 235  THR A CB    1 ? 
ATOM   1823 O OG1   . THR A 1 233 ? 7.060   2.076   53.364 1.00 88.13  ? 235  THR A OG1   1 ? 
ATOM   1824 C CG2   . THR A 1 233 ? 9.397   2.355   53.887 1.00 83.32  ? 235  THR A CG2   1 ? 
ATOM   1825 N N     . VAL A 1 234 ? 7.856   -1.504  52.465 1.00 101.93 ? 236  VAL A N     1 ? 
ATOM   1826 C CA    . VAL A 1 234 ? 6.990   -2.696  52.242 1.00 103.01 ? 236  VAL A CA    1 ? 
ATOM   1827 C C     . VAL A 1 234 ? 6.553   -3.275  53.591 1.00 116.16 ? 236  VAL A C     1 ? 
ATOM   1828 O O     . VAL A 1 234 ? 7.355   -3.199  54.537 1.00 114.50 ? 236  VAL A O     1 ? 
ATOM   1829 C CB    . VAL A 1 234 ? 7.761   -3.760  51.442 1.00 94.22  ? 236  VAL A CB    1 ? 
ATOM   1830 C CG1   . VAL A 1 234 ? 9.086   -4.113  52.098 1.00 93.45  ? 236  VAL A CG1   1 ? 
ATOM   1831 C CG2   . VAL A 1 234 ? 6.932   -5.009  51.197 1.00 97.64  ? 236  VAL A CG2   1 ? 
ATOM   1832 N N     . LYS A 1 235 ? 5.325   -3.799  53.696 1.00 131.91 ? 237  LYS A N     1 ? 
ATOM   1833 C CA    . LYS A 1 235 ? 4.875   -4.518  54.920 1.00 131.95 ? 237  LYS A CA    1 ? 
ATOM   1834 C C     . LYS A 1 235 ? 3.952   -5.655  54.475 1.00 137.72 ? 237  LYS A C     1 ? 
ATOM   1835 O O     . LYS A 1 235 ? 3.070   -5.402  53.640 1.00 127.66 ? 237  LYS A O     1 ? 
ATOM   1836 C CB    . LYS A 1 235 ? 4.126   -3.615  55.896 1.00 135.10 ? 237  LYS A CB    1 ? 
ATOM   1837 C CG    . LYS A 1 235 ? 3.639   -4.322  57.155 1.00 132.61 ? 237  LYS A CG    1 ? 
ATOM   1838 C CD    . LYS A 1 235 ? 2.616   -3.548  57.955 1.00 132.55 ? 237  LYS A CD    1 ? 
ATOM   1839 C CE    . LYS A 1 235 ? 2.062   -4.344  59.119 1.00 134.42 ? 237  LYS A CE    1 ? 
ATOM   1840 N NZ    . LYS A 1 235 ? 0.947   -3.637  59.791 1.00 131.81 ? 237  LYS A NZ    1 ? 
ATOM   1841 N N     . ARG A 1 236 ? 4.158   -6.860  54.999 0.50 145.54 ? 238  ARG A N     1 ? 
ATOM   1842 C CA    . ARG A 1 236 ? 3.350   -8.037  54.583 0.50 148.56 ? 238  ARG A CA    1 ? 
ATOM   1843 C C     . ARG A 1 236 ? 2.449   -8.704  55.618 0.50 150.69 ? 238  ARG A C     1 ? 
ATOM   1844 O O     . ARG A 1 236 ? 1.343   -8.197  55.841 0.50 148.92 ? 238  ARG A O     1 ? 
ATOM   1845 C CB    . ARG A 1 236 ? 4.294   -9.124  54.065 0.50 147.14 ? 238  ARG A CB    1 ? 
ATOM   1846 C CG    . ARG A 1 236 ? 3.639   -10.221 53.239 0.50 146.92 ? 238  ARG A CG    1 ? 
ATOM   1847 C CD    . ARG A 1 236 ? 4.744   -11.086 52.667 0.50 148.23 ? 238  ARG A CD    1 ? 
ATOM   1848 N NE    . ARG A 1 236 ? 5.577   -10.317 51.755 0.50 149.21 ? 238  ARG A NE    1 ? 
ATOM   1849 C CZ    . ARG A 1 236 ? 6.852   -10.015 51.969 0.50 146.98 ? 238  ARG A CZ    1 ? 
ATOM   1850 N NH1   . ARG A 1 236 ? 7.368   -10.140 53.178 0.50 145.97 ? 238  ARG A NH1   1 ? 
ATOM   1851 N NH2   . ARG A 1 236 ? 7.602   -9.571  50.976 0.50 138.29 ? 238  ARG A NH2   1 ? 
ATOM   1852 N N     . ASP A 1 237 ? 2.981   -9.677  56.350 0.50 151.97 ? 239  ASP A N     1 ? 
ATOM   1853 C CA    . ASP A 1 237 ? 2.241   -10.292 57.481 0.50 151.98 ? 239  ASP A CA    1 ? 
ATOM   1854 C C     . ASP A 1 237 ? 3.191   -11.345 58.072 0.50 151.85 ? 239  ASP A C     1 ? 
ATOM   1855 O O     . ASP A 1 237 ? 4.025   -11.872 57.315 0.50 150.02 ? 239  ASP A O     1 ? 
ATOM   1856 C CB    . ASP A 1 237 ? 0.826   -10.804 57.195 0.50 149.69 ? 239  ASP A CB    1 ? 
ATOM   1857 C CG    . ASP A 1 237 ? -0.232  -9.711  57.163 0.50 146.72 ? 239  ASP A CG    1 ? 
ATOM   1858 O OD1   . ASP A 1 237 ? -0.425  -9.049  58.201 0.50 136.78 ? 239  ASP A OD1   1 ? 
ATOM   1859 O OD2   . ASP A 1 237 ? -0.843  -9.520  56.097 0.50 137.97 ? 239  ASP A OD2   1 ? 
ATOM   1860 N N     . VAL A 1 238 ? 3.074   -11.632 59.368 0.50 153.78 ? 240  VAL A N     1 ? 
ATOM   1861 C CA    . VAL A 1 238 ? 3.992   -12.599 60.036 0.50 153.07 ? 240  VAL A CA    1 ? 
ATOM   1862 C C     . VAL A 1 238 ? 5.399   -12.432 59.452 0.50 152.80 ? 240  VAL A C     1 ? 
ATOM   1863 O O     . VAL A 1 238 ? 6.054   -13.456 59.191 0.50 152.62 ? 240  VAL A O     1 ? 
ATOM   1864 C CB    . VAL A 1 238 ? 3.464   -14.037 59.917 0.50 149.96 ? 240  VAL A CB    1 ? 
ATOM   1865 C CG1   . VAL A 1 238 ? 4.074   -14.945 60.975 0.50 143.75 ? 240  VAL A CG1   1 ? 
ATOM   1866 C CG2   . VAL A 1 238 ? 1.946   -14.070 60.010 0.50 139.71 ? 240  VAL A CG2   1 ? 
ATOM   1867 N N     . VAL A 1 239 ? 5.840   -11.192 59.237 0.50 154.19 ? 241  VAL A N     1 ? 
ATOM   1868 C CA    . VAL A 1 239 ? 7.242   -10.936 58.796 0.50 154.03 ? 241  VAL A CA    1 ? 
ATOM   1869 C C     . VAL A 1 239 ? 7.896   -9.961  59.764 0.50 156.92 ? 241  VAL A C     1 ? 
ATOM   1870 O O     . VAL A 1 239 ? 7.228   -9.102  60.346 0.50 157.88 ? 241  VAL A O     1 ? 
ATOM   1871 C CB    . VAL A 1 239 ? 7.298   -10.397 57.356 0.50 152.24 ? 241  VAL A CB    1 ? 
ATOM   1872 C CG1   . VAL A 1 239 ? 6.935   -11.481 56.353 0.50 142.58 ? 241  VAL A CG1   1 ? 
ATOM   1873 C CG2   . VAL A 1 239 ? 6.415   -9.169  57.200 0.50 152.64 ? 241  VAL A CG2   1 ? 
ATOM   1874 N N     . PRO A 1 240 ? 9.230   -10.072 59.953 0.50 163.02 ? 242  PRO A N     1 ? 
ATOM   1875 C CA    . PRO A 1 240 ? 9.961   -9.109  60.775 0.50 162.99 ? 242  PRO A CA    1 ? 
ATOM   1876 C C     . PRO A 1 240 ? 10.134  -7.754  60.065 0.50 161.68 ? 242  PRO A C     1 ? 
ATOM   1877 O O     . PRO A 1 240 ? 11.191  -7.506  59.476 0.50 159.45 ? 242  PRO A O     1 ? 
ATOM   1878 C CB    . PRO A 1 240 ? 11.304  -9.814  61.025 0.50 161.89 ? 242  PRO A CB    1 ? 
ATOM   1879 C CG    . PRO A 1 240 ? 11.492  -10.700 59.805 0.50 159.64 ? 242  PRO A CG    1 ? 
ATOM   1880 C CD    . PRO A 1 240 ? 10.094  -11.149 59.429 0.50 159.24 ? 242  PRO A CD    1 ? 
ATOM   1881 N N     . ASP A 1 241 ? 9.092   -6.917  60.131 0.50 155.54 ? 243  ASP A N     1 ? 
ATOM   1882 C CA    . ASP A 1 241 ? 9.087   -5.543  59.563 0.50 154.86 ? 243  ASP A CA    1 ? 
ATOM   1883 C C     . ASP A 1 241 ? 8.927   -4.529  60.698 0.50 152.76 ? 243  ASP A C     1 ? 
ATOM   1884 O O     . ASP A 1 241 ? 7.769   -4.071  60.949 0.50 134.21 ? 243  ASP A O     1 ? 
ATOM   1885 C CB    . ASP A 1 241 ? 7.998   -5.394  58.498 0.50 153.26 ? 243  ASP A CB    1 ? 
ATOM   1886 C CG    . ASP A 1 241 ? 8.401   -5.935  57.134 0.50 153.50 ? 243  ASP A CG    1 ? 
ATOM   1887 O OD1   . ASP A 1 241 ? 9.616   -5.929  56.829 0.50 145.69 ? 243  ASP A OD1   1 ? 
ATOM   1888 O OD2   . ASP A 1 241 ? 7.496   -6.346  56.374 0.50 137.12 ? 243  ASP A OD2   1 ? 
ATOM   1889 N N     . SER A 1 242 ? 10.050  -4.177  61.334 0.50 154.42 ? 244  SER A N     1 ? 
ATOM   1890 C CA    . SER A 1 242 ? 10.074  -3.184  62.434 0.50 150.48 ? 244  SER A CA    1 ? 
ATOM   1891 C C     . SER A 1 242 ? 9.800   -1.799  61.848 0.50 154.91 ? 244  SER A C     1 ? 
ATOM   1892 O O     . SER A 1 242 ? 10.522  -1.404  60.893 0.50 158.11 ? 244  SER A O     1 ? 
ATOM   1893 C CB    . SER A 1 242 ? 11.391  -3.221  63.172 0.50 137.93 ? 244  SER A CB    1 ? 
ATOM   1894 O OG    . SER A 1 242 ? 12.486  -2.951  62.315 0.50 139.32 ? 244  SER A OG    1 ? 
ATOM   1895 N N     . GLY A 1 243 ? 8.855   -1.082  62.423 0.50 158.13 ? 245  GLY A N     1 ? 
ATOM   1896 C CA    . GLY A 1 243 ? 8.689   0.296   61.954 0.50 156.82 ? 245  GLY A CA    1 ? 
ATOM   1897 C C     . GLY A 1 243 ? 9.820   1.163   62.471 0.50 157.76 ? 245  GLY A C     1 ? 
ATOM   1898 O O     . GLY A 1 243 ? 9.821   1.468   63.678 0.50 154.23 ? 245  GLY A O     1 ? 
ATOM   1899 N N     . ASP A 1 244 ? 10.777  1.513   61.611 0.50 172.67 ? 246  ASP A N     1 ? 
ATOM   1900 C CA    . ASP A 1 244 ? 11.838  2.462   62.037 0.50 177.86 ? 246  ASP A CA    1 ? 
ATOM   1901 C C     . ASP A 1 244 ? 11.289  3.877   61.856 0.50 179.91 ? 246  ASP A C     1 ? 
ATOM   1902 O O     . ASP A 1 244 ? 10.344  4.047   61.066 0.50 179.19 ? 246  ASP A O     1 ? 
ATOM   1903 C CB    . ASP A 1 244 ? 13.158  2.237   61.293 0.50 174.22 ? 246  ASP A CB    1 ? 
ATOM   1904 C CG    . ASP A 1 244 ? 14.245  3.253   61.605 0.50 165.34 ? 246  ASP A CG    1 ? 
ATOM   1905 O OD1   . ASP A 1 244 ? 14.127  4.402   61.145 0.50 151.49 ? 246  ASP A OD1   1 ? 
ATOM   1906 O OD2   . ASP A 1 244 ? 15.221  2.875   62.275 0.50 162.27 ? 246  ASP A OD2   1 ? 
ATOM   1907 N N     . GLY A 1 245 ? 11.860  4.842   62.575 0.50 188.50 ? 247  GLY A N     1 ? 
ATOM   1908 C CA    . GLY A 1 245 ? 11.382  6.228   62.483 0.50 185.54 ? 247  GLY A CA    1 ? 
ATOM   1909 C C     . GLY A 1 245 ? 11.569  6.780   61.093 0.50 187.11 ? 247  GLY A C     1 ? 
ATOM   1910 O O     . GLY A 1 245 ? 10.856  7.729   60.736 0.50 187.63 ? 247  GLY A O     1 ? 
ATOM   1911 N N     . THR A 1 246 ? 12.483  6.203   60.307 0.50 183.60 ? 248  THR A N     1 ? 
ATOM   1912 C CA    . THR A 1 246 ? 12.603  6.637   58.890 0.50 182.65 ? 248  THR A CA    1 ? 
ATOM   1913 C C     . THR A 1 246 ? 11.222  6.493   58.248 0.50 181.66 ? 248  THR A C     1 ? 
ATOM   1914 O O     . THR A 1 246 ? 10.687  7.517   57.776 0.50 180.30 ? 248  THR A O     1 ? 
ATOM   1915 C CB    . THR A 1 246 ? 13.662  5.822   58.138 0.50 181.47 ? 248  THR A CB    1 ? 
ATOM   1916 O OG1   . THR A 1 246 ? 13.391  4.438   58.364 0.50 180.77 ? 248  THR A OG1   1 ? 
ATOM   1917 C CG2   . THR A 1 246 ? 15.074  6.146   58.574 0.50 171.98 ? 248  THR A CG2   1 ? 
ATOM   1918 N N     . ALA A 1 247 ? 10.672  5.274   58.242 0.50 169.70 ? 249  ALA A N     1 ? 
ATOM   1919 C CA    . ALA A 1 247 ? 9.309   5.039   57.709 0.50 167.41 ? 249  ALA A CA    1 ? 
ATOM   1920 C C     . ALA A 1 247 ? 8.854   3.633   58.113 0.50 165.95 ? 249  ALA A C     1 ? 
ATOM   1921 O O     . ALA A 1 247 ? 9.719   2.814   58.481 0.50 164.84 ? 249  ALA A O     1 ? 
ATOM   1922 C CB    . ALA A 1 247 ? 9.284   5.207   56.212 0.50 162.84 ? 249  ALA A CB    1 ? 
ATOM   1923 N N     . THR A 1 248 ? 7.548   3.370   58.034 0.50 149.19 ? 250  THR A N     1 ? 
ATOM   1924 C CA    . THR A 1 248 ? 7.013   2.030   58.393 0.50 149.35 ? 250  THR A CA    1 ? 
ATOM   1925 C C     . THR A 1 248 ? 6.748   1.233   57.112 0.50 147.33 ? 250  THR A C     1 ? 
ATOM   1926 O O     . THR A 1 248 ? 5.925   1.684   56.291 0.50 146.75 ? 250  THR A O     1 ? 
ATOM   1927 C CB    . THR A 1 248 ? 5.769   2.157   59.280 0.50 149.18 ? 250  THR A CB    1 ? 
ATOM   1928 O OG1   . THR A 1 248 ? 4.783   2.896   58.559 0.50 148.26 ? 250  THR A OG1   1 ? 
ATOM   1929 C CG2   . THR A 1 248 ? 6.065   2.840   60.596 0.50 147.37 ? 250  THR A CG2   1 ? 
ATOM   1930 N N     . ALA A 1 249 ? 7.432   0.096   56.962 1.00 135.75 ? 251  ALA A N     1 ? 
ATOM   1931 C CA    . ALA A 1 249 ? 8.222   -0.477  58.076 1.00 129.15 ? 251  ALA A CA    1 ? 
ATOM   1932 C C     . ALA A 1 249 ? 9.664   -0.714  57.618 1.00 123.11 ? 251  ALA A C     1 ? 
ATOM   1933 O O     . ALA A 1 249 ? 10.584  -0.155  58.247 1.00 119.63 ? 251  ALA A O     1 ? 
ATOM   1934 C CB    . ALA A 1 249 ? 7.579   -1.755  58.552 1.00 118.83 ? 251  ALA A CB    1 ? 
ATOM   1935 N N     . GLN A 1 250 ? 9.847   -1.505  56.558 1.00 116.24 ? 252  GLN A N     1 ? 
ATOM   1936 C CA    . GLN A 1 250 ? 11.207  -1.833  56.065 1.00 110.30 ? 252  GLN A CA    1 ? 
ATOM   1937 C C     . GLN A 1 250 ? 11.429  -1.205  54.693 1.00 110.36 ? 252  GLN A C     1 ? 
ATOM   1938 O O     . GLN A 1 250 ? 10.523  -1.188  53.857 1.00 95.11  ? 252  GLN A O     1 ? 
ATOM   1939 C CB    . GLN A 1 250 ? 11.386  -3.343  55.973 1.00 103.80 ? 252  GLN A CB    1 ? 
ATOM   1940 C CG    . GLN A 1 250 ? 12.816  -3.757  55.668 1.00 102.82 ? 252  GLN A CG    1 ? 
ATOM   1941 C CD    . GLN A 1 250 ? 12.939  -5.222  55.328 1.00 106.34 ? 252  GLN A CD    1 ? 
ATOM   1942 O OE1   . GLN A 1 250 ? 11.955  -5.918  55.060 1.00 109.97 ? 252  GLN A OE1   1 ? 
ATOM   1943 N NE2   . GLN A 1 250 ? 14.170  -5.707  55.327 1.00 94.88  ? 252  GLN A NE2   1 ? 
ATOM   1944 N N     . PRO A 1 251 ? 12.640  -0.654  54.434 1.00 102.81 ? 253  PRO A N     1 ? 
ATOM   1945 C CA    . PRO A 1 251 ? 12.997  -0.195  53.095 1.00 92.12  ? 253  PRO A CA    1 ? 
ATOM   1946 C C     . PRO A 1 251 ? 12.908  -1.327  52.073 1.00 82.93  ? 253  PRO A C     1 ? 
ATOM   1947 O O     . PRO A 1 251 ? 13.283  -2.438  52.373 1.00 86.39  ? 253  PRO A O     1 ? 
ATOM   1948 C CB    . PRO A 1 251 ? 14.439  0.303   53.233 1.00 87.82  ? 253  PRO A CB    1 ? 
ATOM   1949 C CG    . PRO A 1 251 ? 14.533  0.695   54.691 1.00 88.44  ? 253  PRO A CG    1 ? 
ATOM   1950 C CD    . PRO A 1 251 ? 13.679  -0.325  55.424 1.00 94.67  ? 253  PRO A CD    1 ? 
ATOM   1951 N N     . LEU A 1 252 ? 12.414  -0.990  50.886 1.00 80.31  ? 254  LEU A N     1 ? 
ATOM   1952 C CA    . LEU A 1 252 ? 12.085  -1.981  49.832 1.00 76.50  ? 254  LEU A CA    1 ? 
ATOM   1953 C C     . LEU A 1 252 ? 13.357  -2.629  49.293 1.00 71.23  ? 254  LEU A C     1 ? 
ATOM   1954 O O     . LEU A 1 252 ? 13.316  -3.846  49.021 1.00 80.13  ? 254  LEU A O     1 ? 
ATOM   1955 C CB    . LEU A 1 252 ? 11.287  -1.270  48.738 1.00 79.38  ? 254  LEU A CB    1 ? 
ATOM   1956 C CG    . LEU A 1 252 ? 11.251  -1.905  47.353 1.00 84.03  ? 254  LEU A CG    1 ? 
ATOM   1957 C CD1   . LEU A 1 252 ? 10.335  -3.119  47.329 1.00 85.22  ? 254  LEU A CD1   1 ? 
ATOM   1958 C CD2   . LEU A 1 252 ? 10.767  -0.874  46.349 1.00 90.58  ? 254  LEU A CD2   1 ? 
ATOM   1959 N N     . VAL A 1 253 ? 14.437  -1.868  49.158 1.00 71.88  ? 255  VAL A N     1 ? 
ATOM   1960 C CA    . VAL A 1 253 ? 15.737  -2.433  48.686 1.00 68.63  ? 255  VAL A CA    1 ? 
ATOM   1961 C C     . VAL A 1 253 ? 16.301  -3.399  49.731 1.00 74.69  ? 255  VAL A C     1 ? 
ATOM   1962 O O     . VAL A 1 253 ? 17.066  -4.333  49.340 1.00 68.31  ? 255  VAL A O     1 ? 
ATOM   1963 C CB    . VAL A 1 253 ? 16.727  -1.311  48.377 1.00 70.59  ? 255  VAL A CB    1 ? 
ATOM   1964 C CG1   . VAL A 1 253 ? 16.221  -0.489  47.215 1.00 70.32  ? 255  VAL A CG1   1 ? 
ATOM   1965 C CG2   . VAL A 1 253 ? 16.993  -0.432  49.594 1.00 73.58  ? 255  VAL A CG2   1 ? 
ATOM   1966 N N     . ASN A 1 254 ? 15.963  -3.181  51.004 1.00 82.68  ? 256  ASN A N     1 ? 
ATOM   1967 C CA    . ASN A 1 254 ? 16.371  -4.105  52.093 1.00 86.51  ? 256  ASN A CA    1 ? 
ATOM   1968 C C     . ASN A 1 254 ? 15.666  -5.443  51.864 1.00 82.57  ? 256  ASN A C     1 ? 
ATOM   1969 O O     . ASN A 1 254 ? 16.335  -6.512  51.973 1.00 83.43  ? 256  ASN A O     1 ? 
ATOM   1970 C CB    . ASN A 1 254 ? 16.068  -3.526  53.476 1.00 89.08  ? 256  ASN A CB    1 ? 
ATOM   1971 C CG    . ASN A 1 254 ? 16.850  -2.267  53.785 1.00 83.74  ? 256  ASN A CG    1 ? 
ATOM   1972 O OD1   . ASN A 1 254 ? 17.649  -1.789  52.983 1.00 84.80  ? 256  ASN A OD1   1 ? 
ATOM   1973 N ND2   . ASN A 1 254 ? 16.619  -1.716  54.956 1.00 90.03  ? 256  ASN A ND2   1 ? 
ATOM   1974 N N     . ASP A 1 255 ? 14.375  -5.391  51.546 1.00 73.43  ? 257  ASP A N     1 ? 
ATOM   1975 C CA    . ASP A 1 255 ? 13.581  -6.618  51.298 1.00 68.31  ? 257  ASP A CA    1 ? 
ATOM   1976 C C     . ASP A 1 255 ? 14.153  -7.337  50.087 1.00 69.28  ? 257  ASP A C     1 ? 
ATOM   1977 O O     . ASP A 1 255 ? 14.322  -8.568  50.146 1.00 75.82  ? 257  ASP A O     1 ? 
ATOM   1978 C CB    . ASP A 1 255 ? 12.116  -6.287  51.073 1.00 82.41  ? 257  ASP A CB    1 ? 
ATOM   1979 C CG    . ASP A 1 255 ? 11.265  -7.526  50.919 1.00 87.27  ? 257  ASP A CG    1 ? 
ATOM   1980 O OD1   . ASP A 1 255 ? 11.196  -8.042  49.790 1.00 92.47  ? 257  ASP A OD1   1 ? 
ATOM   1981 O OD2   . ASP A 1 255 ? 10.696  -7.964  51.928 1.00 93.21  ? 257  ASP A OD2   1 ? 
ATOM   1982 N N     . TRP A 1 256 ? 14.499  -6.589  49.046 1.00 67.95  ? 258  TRP A N     1 ? 
ATOM   1983 C CA    . TRP A 1 256 ? 15.123  -7.195  47.845 1.00 69.27  ? 258  TRP A CA    1 ? 
ATOM   1984 C C     . TRP A 1 256 ? 16.418  -7.909  48.246 1.00 69.72  ? 258  TRP A C     1 ? 
ATOM   1985 O O     . TRP A 1 256 ? 16.567  -9.096  47.935 1.00 76.20  ? 258  TRP A O     1 ? 
ATOM   1986 C CB    . TRP A 1 256 ? 15.378  -6.148  46.758 1.00 69.61  ? 258  TRP A CB    1 ? 
ATOM   1987 C CG    . TRP A 1 256 ? 14.129  -5.613  46.141 1.00 66.10  ? 258  TRP A CG    1 ? 
ATOM   1988 C CD1   . TRP A 1 256 ? 12.904  -6.200  46.135 1.00 65.80  ? 258  TRP A CD1   1 ? 
ATOM   1989 C CD2   . TRP A 1 256 ? 13.991  -4.375  45.424 1.00 68.99  ? 258  TRP A CD2   1 ? 
ATOM   1990 N NE1   . TRP A 1 256 ? 11.998  -5.396  45.496 1.00 68.11  ? 258  TRP A NE1   1 ? 
ATOM   1991 C CE2   . TRP A 1 256 ? 12.639  -4.277  45.039 1.00 68.36  ? 258  TRP A CE2   1 ? 
ATOM   1992 C CE3   . TRP A 1 256 ? 14.875  -3.357  45.057 1.00 64.67  ? 258  TRP A CE3   1 ? 
ATOM   1993 C CZ2   . TRP A 1 256 ? 12.158  -3.209  44.293 1.00 67.62  ? 258  TRP A CZ2   1 ? 
ATOM   1994 C CZ3   . TRP A 1 256 ? 14.393  -2.292  44.338 1.00 67.39  ? 258  TRP A CZ3   1 ? 
ATOM   1995 C CH2   . TRP A 1 256 ? 13.057  -2.226  43.951 1.00 67.54  ? 258  TRP A CH2   1 ? 
ATOM   1996 N N     . LEU A 1 257 ? 17.336  -7.206  48.896 1.00 65.13  ? 259  LEU A N     1 ? 
ATOM   1997 C CA    . LEU A 1 257 ? 18.652  -7.812  49.220 1.00 68.40  ? 259  LEU A CA    1 ? 
ATOM   1998 C C     . LEU A 1 257 ? 18.459  -9.005  50.168 1.00 65.03  ? 259  LEU A C     1 ? 
ATOM   1999 O O     . LEU A 1 257 ? 19.115  -10.051 49.971 1.00 57.38  ? 259  LEU A O     1 ? 
ATOM   2000 C CB    . LEU A 1 257 ? 19.556  -6.749  49.841 1.00 69.60  ? 259  LEU A CB    1 ? 
ATOM   2001 C CG    . LEU A 1 257 ? 20.394  -5.978  48.826 1.00 67.65  ? 259  LEU A CG    1 ? 
ATOM   2002 C CD1   . LEU A 1 257 ? 20.859  -4.657  49.420 1.00 69.22  ? 259  LEU A CD1   1 ? 
ATOM   2003 C CD2   . LEU A 1 257 ? 21.578  -6.807  48.367 1.00 69.85  ? 259  LEU A CD2   1 ? 
ATOM   2004 N N     . ALA A 1 258 ? 17.562  -8.884  51.137 1.00 65.07  ? 260  ALA A N     1 ? 
ATOM   2005 C CA    . ALA A 1 258 ? 17.294  -10.003 52.065 1.00 73.22  ? 260  ALA A CA    1 ? 
ATOM   2006 C C     . ALA A 1 258 ? 16.766  -11.213 51.289 1.00 78.64  ? 260  ALA A C     1 ? 
ATOM   2007 O O     . ALA A 1 258 ? 17.152  -12.345 51.662 1.00 88.57  ? 260  ALA A O     1 ? 
ATOM   2008 C CB    . ALA A 1 258 ? 16.350  -9.575  53.151 1.00 74.43  ? 260  ALA A CB    1 ? 
ATOM   2009 N N     . ALA A 1 259 ? 15.962  -10.997 50.240 1.00 76.73  ? 261  ALA A N     1 ? 
ATOM   2010 C CA    . ALA A 1 259 ? 15.316  -12.089 49.473 1.00 64.22  ? 261  ALA A CA    1 ? 
ATOM   2011 C C     . ALA A 1 259 ? 16.335  -12.798 48.587 1.00 59.68  ? 261  ALA A C     1 ? 
ATOM   2012 O O     . ALA A 1 259 ? 16.007  -13.844 48.043 1.00 72.86  ? 261  ALA A O     1 ? 
ATOM   2013 C CB    . ALA A 1 259 ? 14.168  -11.563 48.666 1.00 72.59  ? 261  ALA A CB    1 ? 
ATOM   2014 N N     . GLY A 1 260 ? 17.539  -12.271 48.436 1.00 59.62  ? 262  GLY A N     1 ? 
ATOM   2015 C CA    . GLY A 1 260 ? 18.599  -12.943 47.650 1.00 62.82  ? 262  GLY A CA    1 ? 
ATOM   2016 C C     . GLY A 1 260 ? 18.768  -12.363 46.248 1.00 67.84  ? 262  GLY A C     1 ? 
ATOM   2017 O O     . GLY A 1 260 ? 19.555  -12.948 45.450 1.00 68.67  ? 262  GLY A O     1 ? 
ATOM   2018 N N     . TYR A 1 261 ? 18.117  -11.243 45.933 1.00 65.80  ? 263  TYR A N     1 ? 
ATOM   2019 C CA    . TYR A 1 261 ? 18.223  -10.640 44.578 1.00 72.33  ? 263  TYR A CA    1 ? 
ATOM   2020 C C     . TYR A 1 261 ? 19.592  -9.978  44.422 1.00 70.17  ? 263  TYR A C     1 ? 
ATOM   2021 O O     . TYR A 1 261 ? 20.122  -9.432  45.395 1.00 71.70  ? 263  TYR A O     1 ? 
ATOM   2022 C CB    . TYR A 1 261 ? 17.055  -9.690  44.308 1.00 68.72  ? 263  TYR A CB    1 ? 
ATOM   2023 C CG    . TYR A 1 261 ? 15.765  -10.441 44.101 1.00 73.12  ? 263  TYR A CG    1 ? 
ATOM   2024 C CD1   . TYR A 1 261 ? 15.474  -11.052 42.880 1.00 67.18  ? 263  TYR A CD1   1 ? 
ATOM   2025 C CD2   . TYR A 1 261 ? 14.875  -10.618 45.150 1.00 68.59  ? 263  TYR A CD2   1 ? 
ATOM   2026 C CE1   . TYR A 1 261 ? 14.319  -11.795 42.702 1.00 65.96  ? 263  TYR A CE1   1 ? 
ATOM   2027 C CE2   . TYR A 1 261 ? 13.706  -11.345 44.981 1.00 73.15  ? 263  TYR A CE2   1 ? 
ATOM   2028 C CZ    . TYR A 1 261 ? 13.434  -11.941 43.757 1.00 70.29  ? 263  TYR A CZ    1 ? 
ATOM   2029 O OH    . TYR A 1 261 ? 12.298  -12.670 43.612 1.00 73.36  ? 263  TYR A OH    1 ? 
ATOM   2030 N N     . GLU A 1 262 ? 20.133  -10.024 43.208 1.00 68.84  ? 264  GLU A N     1 ? 
ATOM   2031 C CA    . GLU A 1 262 ? 21.527  -9.610  42.940 1.00 72.82  ? 264  GLU A CA    1 ? 
ATOM   2032 C C     . GLU A 1 262 ? 21.651  -8.582  41.815 1.00 67.01  ? 264  GLU A C     1 ? 
ATOM   2033 O O     . GLU A 1 262 ? 22.756  -8.029  41.661 1.00 70.42  ? 264  GLU A O     1 ? 
ATOM   2034 C CB    . GLU A 1 262 ? 22.357  -10.837 42.578 1.00 77.04  ? 264  GLU A CB    1 ? 
ATOM   2035 C CG    . GLU A 1 262 ? 22.371  -11.876 43.681 1.00 78.01  ? 264  GLU A CG    1 ? 
ATOM   2036 C CD    . GLU A 1 262 ? 23.208  -13.084 43.325 1.00 83.90  ? 264  GLU A CD    1 ? 
ATOM   2037 O OE1   . GLU A 1 262 ? 23.675  -13.157 42.163 1.00 84.02  ? 264  GLU A OE1   1 ? 
ATOM   2038 O OE2   . GLU A 1 262 ? 23.394  -13.942 44.209 1.00 83.53  ? 264  GLU A OE2   1 ? 
ATOM   2039 N N     . SER A 1 263 ? 20.604  -8.344  41.036 1.00 69.10  ? 265  SER A N     1 ? 
ATOM   2040 C CA    . SER A 1 263 ? 20.661  -7.365  39.922 1.00 66.13  ? 265  SER A CA    1 ? 
ATOM   2041 C C     . SER A 1 263 ? 19.375  -6.547  39.887 1.00 63.62  ? 265  SER A C     1 ? 
ATOM   2042 O O     . SER A 1 263 ? 18.356  -6.987  40.430 1.00 65.55  ? 265  SER A O     1 ? 
ATOM   2043 C CB    . SER A 1 263 ? 20.916  -8.052  38.624 1.00 58.88  ? 265  SER A CB    1 ? 
ATOM   2044 O OG    . SER A 1 263 ? 22.155  -8.727  38.596 1.00 68.66  ? 265  SER A OG    1 ? 
ATOM   2045 N N     . ILE A 1 264 ? 19.449  -5.358  39.308 1.00 61.81  ? 266  ILE A N     1 ? 
ATOM   2046 C CA    . ILE A 1 264 ? 18.236  -4.531  39.066 1.00 53.54  ? 266  ILE A CA    1 ? 
ATOM   2047 C C     . ILE A 1 264 ? 18.357  -3.932  37.678 1.00 55.92  ? 266  ILE A C     1 ? 
ATOM   2048 O O     . ILE A 1 264 ? 19.452  -3.473  37.331 1.00 57.96  ? 266  ILE A O     1 ? 
ATOM   2049 C CB    . ILE A 1 264 ? 18.045  -3.476  40.158 1.00 52.94  ? 266  ILE A CB    1 ? 
ATOM   2050 C CG1   . ILE A 1 264 ? 16.781  -2.669  39.920 1.00 54.25  ? 266  ILE A CG1   1 ? 
ATOM   2051 C CG2   . ILE A 1 264 ? 19.270  -2.578  40.282 1.00 58.28  ? 266  ILE A CG2   1 ? 
ATOM   2052 C CD1   . ILE A 1 264 ? 16.394  -1.811  41.102 1.00 52.00  ? 266  ILE A CD1   1 ? 
ATOM   2053 N N     . VAL A 1 265 ? 17.259  -3.964  36.929 1.00 55.14  ? 267  VAL A N     1 ? 
ATOM   2054 C CA    . VAL A 1 265 ? 17.235  -3.534  35.517 1.00 52.58  ? 267  VAL A CA    1 ? 
ATOM   2055 C C     . VAL A 1 265 ? 16.146  -2.465  35.354 1.00 55.19  ? 267  VAL A C     1 ? 
ATOM   2056 O O     . VAL A 1 265 ? 15.019  -2.641  35.841 1.00 61.54  ? 267  VAL A O     1 ? 
ATOM   2057 C CB    . VAL A 1 265 ? 17.050  -4.737  34.591 1.00 54.18  ? 267  VAL A CB    1 ? 
ATOM   2058 C CG1   . VAL A 1 265 ? 16.828  -4.289  33.164 1.00 68.88  ? 267  VAL A CG1   1 ? 
ATOM   2059 C CG2   . VAL A 1 265 ? 18.235  -5.672  34.651 1.00 59.85  ? 267  VAL A CG2   1 ? 
ATOM   2060 N N     . PHE A 1 266 ? 16.500  -1.377  34.679 1.00 52.02  ? 268  PHE A N     1 ? 
ATOM   2061 C CA    . PHE A 1 266 ? 15.607  -0.238  34.408 1.00 49.10  ? 268  PHE A CA    1 ? 
ATOM   2062 C C     . PHE A 1 266 ? 15.299  -0.240  32.920 1.00 56.60  ? 268  PHE A C     1 ? 
ATOM   2063 O O     . PHE A 1 266 ? 16.221  -0.375  32.111 1.00 59.12  ? 268  PHE A O     1 ? 
ATOM   2064 C CB    . PHE A 1 266 ? 16.270  1.080   34.798 1.00 52.59  ? 268  PHE A CB    1 ? 
ATOM   2065 C CG    . PHE A 1 266 ? 16.343  1.309   36.276 1.00 48.10  ? 268  PHE A CG    1 ? 
ATOM   2066 C CD1   . PHE A 1 266 ? 17.303  0.682   37.036 1.00 47.42  ? 268  PHE A CD1   1 ? 
ATOM   2067 C CD2   . PHE A 1 266 ? 15.426  2.134   36.896 1.00 51.63  ? 268  PHE A CD2   1 ? 
ATOM   2068 C CE1   . PHE A 1 266 ? 17.350  0.899   38.406 1.00 54.03  ? 268  PHE A CE1   1 ? 
ATOM   2069 C CE2   . PHE A 1 266 ? 15.463  2.336   38.268 1.00 57.10  ? 268  PHE A CE2   1 ? 
ATOM   2070 C CZ    . PHE A 1 266 ? 16.433  1.724   39.017 1.00 52.22  ? 268  PHE A CZ    1 ? 
ATOM   2071 N N     . ILE A 1 267 ? 14.022  -0.150  32.587 1.00 52.14  ? 269  ILE A N     1 ? 
ATOM   2072 C CA    . ILE A 1 267 ? 13.546  -0.172  31.189 1.00 50.18  ? 269  ILE A CA    1 ? 
ATOM   2073 C C     . ILE A 1 267 ? 12.534  0.956   30.994 1.00 48.66  ? 269  ILE A C     1 ? 
ATOM   2074 O O     . ILE A 1 267 ? 11.926  1.412   31.966 1.00 49.22  ? 269  ILE A O     1 ? 
ATOM   2075 C CB    . ILE A 1 267 ? 12.903  -1.521  30.836 1.00 48.53  ? 269  ILE A CB    1 ? 
ATOM   2076 C CG1   . ILE A 1 267 ? 11.669  -1.802  31.705 1.00 46.26  ? 269  ILE A CG1   1 ? 
ATOM   2077 C CG2   . ILE A 1 267 ? 13.911  -2.640  30.910 1.00 51.71  ? 269  ILE A CG2   1 ? 
ATOM   2078 C CD1   . ILE A 1 267 ? 10.754  -2.842  31.111 1.00 51.49  ? 269  ILE A CD1   1 ? 
ATOM   2079 N N     . GLN A 1 268 ? 12.305  1.285   29.741 1.00 48.24  ? 270  GLN A N     1 ? 
ATOM   2080 C CA    . GLN A 1 268 ? 11.402  2.364   29.323 1.00 54.25  ? 270  GLN A CA    1 ? 
ATOM   2081 C C     . GLN A 1 268 ? 10.136  1.747   28.716 1.00 52.82  ? 270  GLN A C     1 ? 
ATOM   2082 O O     . GLN A 1 268 ? 10.064  0.531   28.532 1.00 54.16  ? 270  GLN A O     1 ? 
ATOM   2083 C CB    . GLN A 1 268 ? 12.125  3.306   28.351 1.00 56.29  ? 270  GLN A CB    1 ? 
ATOM   2084 C CG    . GLN A 1 268 ? 13.376  3.948   28.967 1.00 59.90  ? 270  GLN A CG    1 ? 
ATOM   2085 C CD    . GLN A 1 268 ? 13.911  5.178   28.263 1.00 58.65  ? 270  GLN A CD    1 ? 
ATOM   2086 O OE1   . GLN A 1 268 ? 14.248  6.171   28.905 1.00 54.40  ? 270  GLN A OE1   1 ? 
ATOM   2087 N NE2   . GLN A 1 268 ? 13.933  5.134   26.937 1.00 65.29  ? 270  GLN A NE2   1 ? 
ATOM   2088 N N     . ASP A 1 269 ? 9.192   2.604   28.389 1.00 47.75  ? 271  ASP A N     1 ? 
ATOM   2089 C CA    . ASP A 1 269 ? 7.783   2.226   28.213 1.00 53.99  ? 271  ASP A CA    1 ? 
ATOM   2090 C C     . ASP A 1 269 ? 7.535   1.520   26.884 1.00 52.46  ? 271  ASP A C     1 ? 
ATOM   2091 O O     . ASP A 1 269 ? 6.613   0.702   26.866 1.00 67.48  ? 271  ASP A O     1 ? 
ATOM   2092 C CB    . ASP A 1 269 ? 6.875   3.443   28.356 1.00 56.82  ? 271  ASP A CB    1 ? 
ATOM   2093 C CG    . ASP A 1 269 ? 7.333   4.692   27.635 1.00 53.16  ? 271  ASP A CG    1 ? 
ATOM   2094 O OD1   . ASP A 1 269 ? 8.294   4.626   26.847 1.00 68.87  ? 271  ASP A OD1   1 ? 
ATOM   2095 O OD2   . ASP A 1 269 ? 6.716   5.707   27.895 1.00 57.49  ? 271  ASP A OD2   1 ? 
ATOM   2096 N N     . THR A 1 270 ? 8.261   1.812   25.810 1.00 53.58  ? 272  THR A N     1 ? 
ATOM   2097 C CA    . THR A 1 270 ? 7.830   1.297   24.491 1.00 52.76  ? 272  THR A CA    1 ? 
ATOM   2098 C C     . THR A 1 270 ? 8.940   0.661   23.694 1.00 51.76  ? 272  THR A C     1 ? 
ATOM   2099 O O     . THR A 1 270 ? 8.920   0.835   22.486 1.00 64.30  ? 272  THR A O     1 ? 
ATOM   2100 C CB    . THR A 1 270 ? 7.156   2.384   23.662 1.00 55.36  ? 272  THR A CB    1 ? 
ATOM   2101 O OG1   . THR A 1 270 ? 8.037   3.496   23.523 1.00 62.06  ? 272  THR A OG1   1 ? 
ATOM   2102 C CG2   . THR A 1 270 ? 5.840   2.805   24.285 1.00 58.58  ? 272  THR A CG2   1 ? 
ATOM   2103 N N     . ASN A 1 271 ? 9.794   -0.135  24.326 1.00 57.15  ? 273  ASN A N     1 ? 
ATOM   2104 C CA    . ASN A 1 271 ? 10.912  -0.820  23.626 1.00 50.91  ? 273  ASN A CA    1 ? 
ATOM   2105 C C     . ASN A 1 271 ? 10.940  -2.309  23.981 1.00 51.91  ? 273  ASN A C     1 ? 
ATOM   2106 O O     . ASN A 1 271 ? 11.545  -2.688  25.018 1.00 61.18  ? 273  ASN A O     1 ? 
ATOM   2107 C CB    . ASN A 1 271 ? 12.248  -0.171  23.969 1.00 52.05  ? 273  ASN A CB    1 ? 
ATOM   2108 C CG    . ASN A 1 271 ? 13.407  -0.746  23.174 1.00 48.28  ? 273  ASN A CG    1 ? 
ATOM   2109 O OD1   . ASN A 1 271 ? 13.226  -1.345  22.112 1.00 49.55  ? 273  ASN A OD1   1 ? 
ATOM   2110 N ND2   . ASN A 1 271 ? 14.596  -0.601  23.705 1.00 47.77  ? 273  ASN A ND2   1 ? 
ATOM   2111 N N     . ALA A 1 272 ? 10.375  -3.120  23.101 1.00 54.71  ? 274  ALA A N     1 ? 
ATOM   2112 C CA    . ALA A 1 272 ? 10.251  -4.581  23.276 1.00 52.27  ? 274  ALA A CA    1 ? 
ATOM   2113 C C     . ALA A 1 272 ? 11.597  -5.265  23.207 1.00 51.88  ? 274  ALA A C     1 ? 
ATOM   2114 O O     . ALA A 1 272 ? 11.684  -6.360  23.774 1.00 57.52  ? 274  ALA A O     1 ? 
ATOM   2115 C CB    . ALA A 1 272 ? 9.353   -5.150  22.216 1.00 51.03  ? 274  ALA A CB    1 ? 
ATOM   2116 N N     . GLY A 1 273 ? 12.585  -4.654  22.539 1.00 54.76  ? 275  GLY A N     1 ? 
ATOM   2117 C CA    . GLY A 1 273 ? 13.924  -5.262  22.402 1.00 52.37  ? 275  GLY A CA    1 ? 
ATOM   2118 C C     . GLY A 1 273 ? 14.581  -5.512  23.752 1.00 45.32  ? 275  GLY A C     1 ? 
ATOM   2119 O O     . GLY A 1 273 ? 15.467  -6.320  23.821 1.00 57.18  ? 275  GLY A O     1 ? 
ATOM   2120 N N     . ALA A 1 274 ? 14.144  -4.825  24.794 1.00 43.70  ? 276  ALA A N     1 ? 
ATOM   2121 C CA    . ALA A 1 274 ? 14.696  -5.014  26.152 1.00 47.96  ? 276  ALA A CA    1 ? 
ATOM   2122 C C     . ALA A 1 274 ? 14.646  -6.501  26.562 1.00 50.87  ? 276  ALA A C     1 ? 
ATOM   2123 O O     . ALA A 1 274 ? 15.577  -6.957  27.226 1.00 55.48  ? 276  ALA A O     1 ? 
ATOM   2124 C CB    . ALA A 1 274 ? 13.971  -4.154  27.154 1.00 52.83  ? 276  ALA A CB    1 ? 
ATOM   2125 N N     . THR A 1 275 ? 13.588  -7.226  26.178 1.00 51.05  ? 277  THR A N     1 ? 
ATOM   2126 C CA    . THR A 1 275 ? 13.494  -8.672  26.519 1.00 49.18  ? 277  THR A CA    1 ? 
ATOM   2127 C C     . THR A 1 275 ? 14.583  -9.480  25.830 1.00 45.94  ? 277  THR A C     1 ? 
ATOM   2128 O O     . THR A 1 275 ? 14.920  -10.546 26.338 1.00 55.54  ? 277  THR A O     1 ? 
ATOM   2129 C CB    . THR A 1 275 ? 12.130  -9.242  26.187 1.00 44.87  ? 277  THR A CB    1 ? 
ATOM   2130 O OG1   . THR A 1 275 ? 11.892  -8.996  24.810 1.00 54.72  ? 277  THR A OG1   1 ? 
ATOM   2131 C CG2   . THR A 1 275 ? 11.083  -8.607  27.078 1.00 44.00  ? 277  THR A CG2   1 ? 
ATOM   2132 N N     . ILE A 1 276 ? 15.095  -9.001  24.717 1.00 49.36  ? 278  ILE A N     1 ? 
ATOM   2133 C CA    . ILE A 1 276 ? 16.233  -9.658  24.029 1.00 54.09  ? 278  ILE A CA    1 ? 
ATOM   2134 C C     . ILE A 1 276 ? 17.561  -9.142  24.603 1.00 55.95  ? 278  ILE A C     1 ? 
ATOM   2135 O O     . ILE A 1 276 ? 18.522  -9.908  24.696 1.00 65.08  ? 278  ILE A O     1 ? 
ATOM   2136 C CB    . ILE A 1 276 ? 16.144  -9.391  22.531 1.00 55.43  ? 278  ILE A CB    1 ? 
ATOM   2137 C CG1   . ILE A 1 276 ? 14.864  -9.996  21.962 1.00 59.75  ? 278  ILE A CG1   1 ? 
ATOM   2138 C CG2   . ILE A 1 276 ? 17.387  -9.942  21.840 1.00 66.40  ? 278  ILE A CG2   1 ? 
ATOM   2139 C CD1   . ILE A 1 276 ? 14.968  -11.498 21.675 1.00 66.11  ? 278  ILE A CD1   1 ? 
ATOM   2140 N N     . THR A 1 277 ? 17.591  -7.884  24.986 1.00 57.66  ? 279  THR A N     1 ? 
ATOM   2141 C CA    . THR A 1 277 ? 18.830  -7.224  25.456 1.00 53.84  ? 279  THR A CA    1 ? 
ATOM   2142 C C     . THR A 1 277 ? 19.216  -7.741  26.844 1.00 58.13  ? 279  THR A C     1 ? 
ATOM   2143 O O     . THR A 1 277 ? 20.390  -8.054  27.036 1.00 50.62  ? 279  THR A O     1 ? 
ATOM   2144 C CB    . THR A 1 277 ? 18.647  -5.704  25.453 1.00 50.31  ? 279  THR A CB    1 ? 
ATOM   2145 O OG1   . THR A 1 277 ? 19.175  -5.287  24.199 1.00 60.75  ? 279  THR A OG1   1 ? 
ATOM   2146 C CG2   . THR A 1 277 ? 19.338  -5.056  26.619 1.00 61.04  ? 279  THR A CG2   1 ? 
ATOM   2147 N N     . ILE A 1 278 ? 18.271  -7.763  27.779 1.00 58.64  ? 280  ILE A N     1 ? 
ATOM   2148 C CA    . ILE A 1 278 ? 18.590  -7.804  29.229 1.00 54.48  ? 280  ILE A CA    1 ? 
ATOM   2149 C C     . ILE A 1 278 ? 19.430  -9.051  29.539 1.00 59.74  ? 280  ILE A C     1 ? 
ATOM   2150 O O     . ILE A 1 278 ? 20.450  -8.948  30.219 1.00 59.09  ? 280  ILE A O     1 ? 
ATOM   2151 C CB    . ILE A 1 278 ? 17.312  -7.673  30.070 1.00 57.21  ? 280  ILE A CB    1 ? 
ATOM   2152 C CG1   . ILE A 1 278 ? 16.791  -6.238  30.036 1.00 53.38  ? 280  ILE A CG1   1 ? 
ATOM   2153 C CG2   . ILE A 1 278 ? 17.521  -8.145  31.500 1.00 57.74  ? 280  ILE A CG2   1 ? 
ATOM   2154 C CD1   . ILE A 1 278 ? 15.345  -6.128  30.395 1.00 60.33  ? 280  ILE A CD1   1 ? 
ATOM   2155 N N     . PRO A 1 279 ? 19.064  -10.283 29.118 1.00 64.55  ? 281  PRO A N     1 ? 
ATOM   2156 C CA    . PRO A 1 279 ? 19.825  -11.458 29.563 1.00 60.29  ? 281  PRO A CA    1 ? 
ATOM   2157 C C     . PRO A 1 279 ? 21.307  -11.399 29.182 1.00 57.72  ? 281  PRO A C     1 ? 
ATOM   2158 O O     . PRO A 1 279 ? 22.149  -11.679 29.996 1.00 66.14  ? 281  PRO A O     1 ? 
ATOM   2159 C CB    . PRO A 1 279 ? 19.152  -12.652 28.867 1.00 55.62  ? 281  PRO A CB    1 ? 
ATOM   2160 C CG    . PRO A 1 279 ? 18.228  -12.041 27.811 1.00 57.76  ? 281  PRO A CG    1 ? 
ATOM   2161 C CD    . PRO A 1 279 ? 17.855  -10.669 28.346 1.00 58.10  ? 281  PRO A CD    1 ? 
ATOM   2162 N N     . ILE A 1 280 ? 21.584  -11.019 27.943 1.00 58.93  ? 282  ILE A N     1 ? 
ATOM   2163 C CA    . ILE A 1 280 ? 22.990  -10.893 27.463 1.00 56.71  ? 282  ILE A CA    1 ? 
ATOM   2164 C C     . ILE A 1 280 ? 23.724  -9.894  28.351 1.00 55.29  ? 282  ILE A C     1 ? 
ATOM   2165 O O     . ILE A 1 280 ? 24.765  -10.231 28.861 1.00 63.86  ? 282  ILE A O     1 ? 
ATOM   2166 C CB    . ILE A 1 280 ? 23.023  -10.481 25.986 1.00 55.78  ? 282  ILE A CB    1 ? 
ATOM   2167 C CG1   . ILE A 1 280 ? 22.211  -11.460 25.120 1.00 61.09  ? 282  ILE A CG1   1 ? 
ATOM   2168 C CG2   . ILE A 1 280 ? 24.458  -10.359 25.510 1.00 59.49  ? 282  ILE A CG2   1 ? 
ATOM   2169 C CD1   . ILE A 1 280 ? 22.926  -12.747 24.756 1.00 58.28  ? 282  ILE A CD1   1 ? 
ATOM   2170 N N     . SER A 1 281 ? 23.166  -8.711  28.537 1.00 56.45  ? 283  SER A N     1 ? 
ATOM   2171 C CA    . SER A 1 281 ? 23.804  -7.648  29.357 1.00 58.18  ? 283  SER A CA    1 ? 
ATOM   2172 C C     . SER A 1 281 ? 24.123  -8.216  30.733 1.00 59.86  ? 283  SER A C     1 ? 
ATOM   2173 O O     . SER A 1 281 ? 25.232  -7.995  31.213 1.00 71.94  ? 283  SER A O     1 ? 
ATOM   2174 C CB    . SER A 1 281 ? 22.905  -6.442  29.491 1.00 51.66  ? 283  SER A CB    1 ? 
ATOM   2175 O OG    . SER A 1 281 ? 22.742  -5.779  28.261 1.00 64.86  ? 283  SER A OG    1 ? 
ATOM   2176 N N     . LEU A 1 282 ? 23.172  -8.912  31.348 1.00 59.92  ? 284  LEU A N     1 ? 
ATOM   2177 C CA    . LEU A 1 282 ? 23.375  -9.482  32.703 1.00 60.91  ? 284  LEU A CA    1 ? 
ATOM   2178 C C     . LEU A 1 282 ? 24.580  -10.424 32.670 1.00 59.67  ? 284  LEU A C     1 ? 
ATOM   2179 O O     . LEU A 1 282 ? 25.444  -10.344 33.558 1.00 68.29  ? 284  LEU A O     1 ? 
ATOM   2180 C CB    . LEU A 1 282 ? 22.124  -10.239 33.145 1.00 62.56  ? 284  LEU A CB    1 ? 
ATOM   2181 C CG    . LEU A 1 282 ? 21.061  -9.394  33.831 1.00 63.16  ? 284  LEU A CG    1 ? 
ATOM   2182 C CD1   . LEU A 1 282 ? 19.739  -10.153 33.917 1.00 56.51  ? 284  LEU A CD1   1 ? 
ATOM   2183 C CD2   . LEU A 1 282 ? 21.536  -8.981  35.211 1.00 61.55  ? 284  LEU A CD2   1 ? 
ATOM   2184 N N     . ALA A 1 283 ? 24.647  -11.297 31.685 1.00 55.09  ? 285  ALA A N     1 ? 
ATOM   2185 C CA    . ALA A 1 283 ? 25.753  -12.270 31.589 1.00 58.99  ? 285  ALA A CA    1 ? 
ATOM   2186 C C     . ALA A 1 283 ? 27.068  -11.514 31.465 1.00 66.65  ? 285  ALA A C     1 ? 
ATOM   2187 O O     . ALA A 1 283 ? 28.005  -11.877 32.190 1.00 73.75  ? 285  ALA A O     1 ? 
ATOM   2188 C CB    . ALA A 1 283 ? 25.553  -13.191 30.429 1.00 55.88  ? 285  ALA A CB    1 ? 
ATOM   2189 N N     . LEU A 1 284 ? 27.101  -10.494 30.608 1.00 65.62  ? 286  LEU A N     1 ? 
ATOM   2190 C CA    . LEU A 1 284 ? 28.320  -9.696  30.376 1.00 63.03  ? 286  LEU A CA    1 ? 
ATOM   2191 C C     . LEU A 1 284 ? 28.652  -8.865  31.613 1.00 68.90  ? 286  LEU A C     1 ? 
ATOM   2192 O O     . LEU A 1 284 ? 29.839  -8.578  31.810 1.00 79.44  ? 286  LEU A O     1 ? 
ATOM   2193 C CB    . LEU A 1 284 ? 28.157  -8.827  29.136 1.00 58.89  ? 286  LEU A CB    1 ? 
ATOM   2194 C CG    . LEU A 1 284 ? 28.302  -9.626  27.853 1.00 65.37  ? 286  LEU A CG    1 ? 
ATOM   2195 C CD1   . LEU A 1 284 ? 27.955  -8.786  26.649 1.00 61.29  ? 286  LEU A CD1   1 ? 
ATOM   2196 C CD2   . LEU A 1 284 ? 29.712  -10.205 27.728 1.00 70.88  ? 286  LEU A CD2   1 ? 
ATOM   2197 N N     . SER A 1 285 ? 27.666  -8.499  32.419 1.00 66.13  ? 287  SER A N     1 ? 
ATOM   2198 C CA    . SER A 1 285 ? 27.940  -7.801  33.694 1.00 64.20  ? 287  SER A CA    1 ? 
ATOM   2199 C C     . SER A 1 285 ? 28.660  -8.746  34.646 1.00 69.62  ? 287  SER A C     1 ? 
ATOM   2200 O O     . SER A 1 285 ? 29.544  -8.268  35.375 1.00 70.33  ? 287  SER A O     1 ? 
ATOM   2201 C CB    . SER A 1 285 ? 26.682  -7.236  34.299 1.00 65.12  ? 287  SER A CB    1 ? 
ATOM   2202 O OG    . SER A 1 285 ? 26.228  -6.107  33.559 1.00 70.19  ? 287  SER A OG    1 ? 
ATOM   2203 N N     . ALA A 1 286 ? 28.299  -10.030 34.633 1.00 75.68  ? 288  ALA A N     1 ? 
ATOM   2204 C CA    . ALA A 1 286 ? 28.894  -11.038 35.538 1.00 73.55  ? 288  ALA A CA    1 ? 
ATOM   2205 C C     . ALA A 1 286 ? 30.302  -11.361 35.039 1.00 69.59  ? 288  ALA A C     1 ? 
ATOM   2206 O O     . ALA A 1 286 ? 31.237  -11.373 35.854 1.00 75.19  ? 288  ALA A O     1 ? 
ATOM   2207 C CB    . ALA A 1 286 ? 28.014  -12.266 35.624 1.00 71.72  ? 288  ALA A CB    1 ? 
ATOM   2208 N N     . GLU A 1 287 ? 30.452  -11.574 33.741 1.00 72.14  ? 289  GLU A N     1 ? 
ATOM   2209 C CA    . GLU A 1 287 ? 31.747  -11.990 33.153 1.00 80.70  ? 289  GLU A CA    1 ? 
ATOM   2210 C C     . GLU A 1 287 ? 32.810  -10.914 33.396 1.00 89.68  ? 289  GLU A C     1 ? 
ATOM   2211 O O     . GLU A 1 287 ? 33.967  -11.310 33.674 1.00 99.56  ? 289  GLU A O     1 ? 
ATOM   2212 C CB    . GLU A 1 287 ? 31.578  -12.271 31.666 1.00 81.25  ? 289  GLU A CB    1 ? 
ATOM   2213 C CG    . GLU A 1 287 ? 32.865  -12.652 30.974 1.00 93.59  ? 289  GLU A CG    1 ? 
ATOM   2214 C CD    . GLU A 1 287 ? 32.632  -13.289 29.612 1.00 106.49 ? 289  GLU A CD    1 ? 
ATOM   2215 O OE1   . GLU A 1 287 ? 31.682  -14.112 29.490 1.00 102.71 ? 289  GLU A OE1   1 ? 
ATOM   2216 O OE2   . GLU A 1 287 ? 33.381  -12.948 28.663 1.00 105.32 ? 289  GLU A OE2   1 ? 
ATOM   2217 N N     . HIS A 1 288 ? 32.454  -9.627  33.276 1.00 83.30  ? 290  HIS A N     1 ? 
ATOM   2218 C CA    . HIS A 1 288 ? 33.417  -8.498  33.345 1.00 73.58  ? 290  HIS A CA    1 ? 
ATOM   2219 C C     . HIS A 1 288 ? 33.187  -7.661  34.595 1.00 75.81  ? 290  HIS A C     1 ? 
ATOM   2220 O O     . HIS A 1 288 ? 33.706  -6.536  34.649 1.00 79.65  ? 290  HIS A O     1 ? 
ATOM   2221 C CB    . HIS A 1 288 ? 33.321  -7.634  32.106 1.00 72.12  ? 290  HIS A CB    1 ? 
ATOM   2222 C CG    . HIS A 1 288 ? 33.596  -8.381  30.851 1.00 71.93  ? 290  HIS A CG    1 ? 
ATOM   2223 N ND1   . HIS A 1 288 ? 32.618  -9.073  30.188 1.00 87.65  ? 290  HIS A ND1   1 ? 
ATOM   2224 C CD2   . HIS A 1 288 ? 34.720  -8.522  30.124 1.00 80.43  ? 290  HIS A CD2   1 ? 
ATOM   2225 C CE1   . HIS A 1 288 ? 33.114  -9.597  29.079 1.00 89.67  ? 290  HIS A CE1   1 ? 
ATOM   2226 N NE2   . HIS A 1 288 ? 34.409  -9.279  29.022 1.00 91.25  ? 290  HIS A NE2   1 ? 
ATOM   2227 N N     . SER A 1 289 ? 32.432  -8.181  35.555 1.00 76.01  ? 291  SER A N     1 ? 
ATOM   2228 C CA    . SER A 1 289 ? 32.304  -7.564  36.900 1.00 79.09  ? 291  SER A CA    1 ? 
ATOM   2229 C C     . SER A 1 289 ? 31.929  -6.087  36.757 1.00 76.19  ? 291  SER A C     1 ? 
ATOM   2230 O O     . SER A 1 289 ? 32.547  -5.244  37.415 1.00 89.09  ? 291  SER A O     1 ? 
ATOM   2231 C CB    . SER A 1 289 ? 33.583  -7.735  37.695 1.00 78.77  ? 291  SER A CB    1 ? 
ATOM   2232 O OG    . SER A 1 289 ? 33.901  -9.122  37.845 1.00 76.92  ? 291  SER A OG    1 ? 
ATOM   2233 N N     . LEU A 1 290 ? 30.933  -5.794  35.931 1.00 77.25  ? 292  LEU A N     1 ? 
ATOM   2234 C CA    . LEU A 1 290 ? 30.402  -4.420  35.782 1.00 71.49  ? 292  LEU A CA    1 ? 
ATOM   2235 C C     . LEU A 1 290 ? 29.384  -4.136  36.878 1.00 71.61  ? 292  LEU A C     1 ? 
ATOM   2236 O O     . LEU A 1 290 ? 28.489  -4.958  37.085 1.00 80.38  ? 292  LEU A O     1 ? 
ATOM   2237 C CB    . LEU A 1 290 ? 29.758  -4.263  34.412 1.00 66.18  ? 292  LEU A CB    1 ? 
ATOM   2238 C CG    . LEU A 1 290 ? 30.696  -4.465  33.238 1.00 76.79  ? 292  LEU A CG    1 ? 
ATOM   2239 C CD1   . LEU A 1 290 ? 30.058  -3.939  31.967 1.00 75.63  ? 292  LEU A CD1   1 ? 
ATOM   2240 C CD2   . LEU A 1 290 ? 32.038  -3.794  33.497 1.00 79.83  ? 292  LEU A CD2   1 ? 
ATOM   2241 N N     . ASP A 1 291 ? 29.545  -2.999  37.541 1.00 73.84  ? 293  ASP A N     1 ? 
ATOM   2242 C CA    . ASP A 1 291 ? 28.587  -2.511  38.559 1.00 73.07  ? 293  ASP A CA    1 ? 
ATOM   2243 C C     . ASP A 1 291 ? 27.401  -1.840  37.871 1.00 72.08  ? 293  ASP A C     1 ? 
ATOM   2244 O O     . ASP A 1 291 ? 26.296  -1.852  38.436 1.00 68.66  ? 293  ASP A O     1 ? 
ATOM   2245 C CB    . ASP A 1 291 ? 29.262  -1.525  39.501 1.00 75.14  ? 293  ASP A CB    1 ? 
ATOM   2246 C CG    . ASP A 1 291 ? 30.230  -2.220  40.424 1.00 73.70  ? 293  ASP A CG    1 ? 
ATOM   2247 O OD1   . ASP A 1 291 ? 29.748  -2.937  41.322 1.00 72.39  ? 293  ASP A OD1   1 ? 
ATOM   2248 O OD2   . ASP A 1 291 ? 31.451  -2.043  40.209 1.00 74.26  ? 293  ASP A OD2   1 ? 
ATOM   2249 N N     . MET A 1 292 ? 27.638  -1.226  36.723 1.00 70.39  ? 294  MET A N     1 ? 
ATOM   2250 C CA    . MET A 1 292 ? 26.564  -0.560  35.964 1.00 64.34  ? 294  MET A CA    1 ? 
ATOM   2251 C C     . MET A 1 292 ? 26.856  -0.782  34.497 1.00 68.06  ? 294  MET A C     1 ? 
ATOM   2252 O O     . MET A 1 292 ? 27.999  -0.538  34.089 1.00 71.49  ? 294  MET A O     1 ? 
ATOM   2253 C CB    . MET A 1 292 ? 26.477  0.942   36.251 1.00 70.59  ? 294  MET A CB    1 ? 
ATOM   2254 C CG    . MET A 1 292 ? 25.315  1.610   35.543 1.00 69.37  ? 294  MET A CG    1 ? 
ATOM   2255 S SD    . MET A 1 292 ? 25.389  3.375   35.601 1.00 74.44  ? 294  MET A SD    1 ? 
ATOM   2256 C CE    . MET A 1 292 ? 23.907  3.836   34.716 1.00 72.33  ? 294  MET A CE    1 ? 
ATOM   2257 N N     . ASN A 1 293 ? 25.831  -1.210  33.759 1.00 64.63  ? 295  ASN A N     1 ? 
ATOM   2258 C CA    . ASN A 1 293 ? 25.965  -1.575  32.333 1.00 65.70  ? 295  ASN A CA    1 ? 
ATOM   2259 C C     . ASN A 1 293 ? 24.932  -0.811  31.515 1.00 63.40  ? 295  ASN A C     1 ? 
ATOM   2260 O O     . ASN A 1 293 ? 23.744  -1.033  31.718 1.00 66.08  ? 295  ASN A O     1 ? 
ATOM   2261 C CB    . ASN A 1 293 ? 25.829  -3.075  32.159 1.00 60.40  ? 295  ASN A CB    1 ? 
ATOM   2262 C CG    . ASN A 1 293 ? 26.274  -3.543  30.795 1.00 59.67  ? 295  ASN A CG    1 ? 
ATOM   2263 O OD1   . ASN A 1 293 ? 26.546  -2.736  29.908 1.00 64.68  ? 295  ASN A OD1   1 ? 
ATOM   2264 N ND2   . ASN A 1 293 ? 26.312  -4.851  30.612 1.00 56.78  ? 295  ASN A ND2   1 ? 
ATOM   2265 N N     . PHE A 1 294 ? 25.405  0.064   30.637 1.00 65.52  ? 296  PHE A N     1 ? 
ATOM   2266 C CA    . PHE A 1 294 ? 24.563  0.818   29.687 1.00 62.33  ? 296  PHE A CA    1 ? 
ATOM   2267 C C     . PHE A 1 294 ? 24.284  -0.057  28.486 1.00 59.73  ? 296  PHE A C     1 ? 
ATOM   2268 O O     . PHE A 1 294 ? 25.219  -0.642  27.928 1.00 63.85  ? 296  PHE A O     1 ? 
ATOM   2269 C CB    . PHE A 1 294 ? 25.256  2.080   29.188 1.00 64.04  ? 296  PHE A CB    1 ? 
ATOM   2270 C CG    . PHE A 1 294 ? 25.221  3.235   30.142 1.00 58.90  ? 296  PHE A CG    1 ? 
ATOM   2271 C CD1   . PHE A 1 294 ? 26.114  3.310   31.191 1.00 64.87  ? 296  PHE A CD1   1 ? 
ATOM   2272 C CD2   . PHE A 1 294 ? 24.312  4.262   29.966 1.00 66.07  ? 296  PHE A CD2   1 ? 
ATOM   2273 C CE1   . PHE A 1 294 ? 26.076  4.382   32.068 1.00 68.27  ? 296  PHE A CE1   1 ? 
ATOM   2274 C CE2   . PHE A 1 294 ? 24.288  5.347   30.829 1.00 67.30  ? 296  PHE A CE2   1 ? 
ATOM   2275 C CZ    . PHE A 1 294 ? 25.174  5.405   31.882 1.00 64.82  ? 296  PHE A CZ    1 ? 
ATOM   2276 N N     . THR A 1 295 ? 23.029  -0.119  28.089 1.00 67.21  ? 297  THR A N     1 ? 
ATOM   2277 C CA    . THR A 1 295 ? 22.663  -0.794  26.830 1.00 64.86  ? 297  THR A CA    1 ? 
ATOM   2278 C C     . THR A 1 295 ? 22.814  0.175   25.682 1.00 55.60  ? 297  THR A C     1 ? 
ATOM   2279 O O     . THR A 1 295 ? 22.176  1.229   25.755 1.00 62.85  ? 297  THR A O     1 ? 
ATOM   2280 C CB    . THR A 1 295 ? 21.229  -1.315  26.846 1.00 64.82  ? 297  THR A CB    1 ? 
ATOM   2281 O OG1   . THR A 1 295 ? 21.016  -1.985  28.090 1.00 56.46  ? 297  THR A OG1   1 ? 
ATOM   2282 C CG2   . THR A 1 295 ? 21.020  -2.286  25.712 1.00 59.95  ? 297  THR A CG2   1 ? 
ATOM   2283 N N     . CYS A 1 296 ? 23.605  -0.202  24.686 1.00 54.10  ? 298  CYS A N     1 ? 
ATOM   2284 C CA    . CYS A 1 296 ? 24.082  0.743   23.643 1.00 60.60  ? 298  CYS A CA    1 ? 
ATOM   2285 C C     . CYS A 1 296 ? 23.866  0.131   22.271 1.00 59.99  ? 298  CYS A C     1 ? 
ATOM   2286 O O     . CYS A 1 296 ? 23.817  -1.106  22.149 1.00 60.38  ? 298  CYS A O     1 ? 
ATOM   2287 C CB    . CYS A 1 296 ? 25.543  1.152   23.846 1.00 60.04  ? 298  CYS A CB    1 ? 
ATOM   2288 S SG    . CYS A 1 296 ? 25.858  1.830   25.500 1.00 71.42  ? 298  CYS A SG    1 ? 
ATOM   2289 N N     . ILE A 1 297 ? 23.692  1.004   21.290 1.00 58.16  ? 299  ILE A N     1 ? 
ATOM   2290 C CA    . ILE A 1 297 ? 23.702  0.619   19.859 1.00 58.01  ? 299  ILE A CA    1 ? 
ATOM   2291 C C     . ILE A 1 297 ? 24.658  1.551   19.132 1.00 66.20  ? 299  ILE A C     1 ? 
ATOM   2292 O O     . ILE A 1 297 ? 24.992  2.627   19.625 1.00 70.77  ? 299  ILE A O     1 ? 
ATOM   2293 C CB    . ILE A 1 297 ? 22.284  0.676   19.286 1.00 61.57  ? 299  ILE A CB    1 ? 
ATOM   2294 C CG1   . ILE A 1 297 ? 21.726  2.099   19.355 1.00 63.33  ? 299  ILE A CG1   1 ? 
ATOM   2295 C CG2   . ILE A 1 297 ? 21.377  -0.320  19.998 1.00 63.30  ? 299  ILE A CG2   1 ? 
ATOM   2296 C CD1   . ILE A 1 297 ? 20.447  2.292   18.578 1.00 59.86  ? 299  ILE A CD1   1 ? 
ATOM   2297 N N     . PRO A 1 298 ? 25.150  1.167   17.941 1.00 66.46  ? 300  PRO A N     1 ? 
ATOM   2298 C CA    . PRO A 1 298 ? 25.873  2.109   17.100 1.00 64.15  ? 300  PRO A CA    1 ? 
ATOM   2299 C C     . PRO A 1 298 ? 24.957  3.272   16.746 1.00 60.88  ? 300  PRO A C     1 ? 
ATOM   2300 O O     . PRO A 1 298 ? 23.862  3.043   16.312 1.00 72.87  ? 300  PRO A O     1 ? 
ATOM   2301 C CB    . PRO A 1 298 ? 26.258  1.286   15.870 1.00 69.49  ? 300  PRO A CB    1 ? 
ATOM   2302 C CG    . PRO A 1 298 ? 26.215  -0.140  16.359 1.00 68.88  ? 300  PRO A CG    1 ? 
ATOM   2303 C CD    . PRO A 1 298 ? 25.092  -0.176  17.365 1.00 64.29  ? 300  PRO A CD    1 ? 
ATOM   2304 N N     . ARG A 1 299 ? 25.447  4.482   16.954 1.00 75.30  ? 301  ARG A N     1 ? 
ATOM   2305 C CA    . ARG A 1 299 ? 24.634  5.707   16.785 1.00 75.29  ? 301  ARG A CA    1 ? 
ATOM   2306 C C     . ARG A 1 299 ? 25.008  6.353   15.458 1.00 79.09  ? 301  ARG A C     1 ? 
ATOM   2307 O O     . ARG A 1 299 ? 26.208  6.404   15.140 1.00 86.05  ? 301  ARG A O     1 ? 
ATOM   2308 C CB    . ARG A 1 299 ? 24.849  6.637   17.971 1.00 71.44  ? 301  ARG A CB    1 ? 
ATOM   2309 C CG    . ARG A 1 299 ? 24.084  7.940   17.876 1.00 77.02  ? 301  ARG A CG    1 ? 
ATOM   2310 C CD    . ARG A 1 299 ? 24.033  8.630   19.232 1.00 86.57  ? 301  ARG A CD    1 ? 
ATOM   2311 N NE    . ARG A 1 299 ? 23.421  9.956   19.171 1.00 93.81  ? 301  ARG A NE    1 ? 
ATOM   2312 C CZ    . ARG A 1 299 ? 23.930  11.015  18.538 1.00 88.58  ? 301  ARG A CZ    1 ? 
ATOM   2313 N NH1   . ARG A 1 299 ? 25.087  10.930  17.897 1.00 92.12  ? 301  ARG A NH1   1 ? 
ATOM   2314 N NH2   . ARG A 1 299 ? 23.269  12.157  18.547 1.00 79.91  ? 301  ARG A NH2   1 ? 
ATOM   2315 N N     . VAL A 1 300 ? 24.002  6.780   14.701 1.00 88.08  ? 302  VAL A N     1 ? 
ATOM   2316 C CA    . VAL A 1 300 ? 24.194  7.698   13.544 1.00 94.26  ? 302  VAL A CA    1 ? 
ATOM   2317 C C     . VAL A 1 300 ? 24.267  9.120   14.094 1.00 98.64  ? 302  VAL A C     1 ? 
ATOM   2318 O O     . VAL A 1 300 ? 23.539  9.462   15.028 1.00 98.18  ? 302  VAL A O     1 ? 
ATOM   2319 C CB    . VAL A 1 300 ? 23.068  7.540   12.512 1.00 95.42  ? 302  VAL A CB    1 ? 
ATOM   2320 C CG1   . VAL A 1 300 ? 22.955  6.095   12.048 1.00 93.13  ? 302  VAL A CG1   1 ? 
ATOM   2321 C CG2   . VAL A 1 300 ? 21.736  8.036   13.047 1.00 95.31  ? 302  VAL A CG2   1 ? 
ATOM   2322 N N     . PRO A 1 301 ? 25.134  9.999   13.538 1.00 113.72 ? 303  PRO A N     1 ? 
ATOM   2323 C CA    . PRO A 1 301 ? 25.379  11.317  14.140 1.00 114.34 ? 303  PRO A CA    1 ? 
ATOM   2324 C C     . PRO A 1 301 ? 24.138  12.198  14.347 1.00 103.28 ? 303  PRO A C     1 ? 
ATOM   2325 O O     . PRO A 1 301 ? 24.136  13.016  15.248 1.00 100.85 ? 303  PRO A O     1 ? 
ATOM   2326 C CB    . PRO A 1 301 ? 26.308  12.008  13.131 1.00 111.35 ? 303  PRO A CB    1 ? 
ATOM   2327 C CG    . PRO A 1 301 ? 27.000  10.864  12.417 1.00 110.75 ? 303  PRO A CG    1 ? 
ATOM   2328 C CD    . PRO A 1 301 ? 25.964  9.759   12.343 1.00 114.30 ? 303  PRO A CD    1 ? 
ATOM   2329 N N     . LYS A 1 302 ? 23.137  12.024  13.492 1.00 104.16 ? 304  LYS A N     1 ? 
ATOM   2330 C CA    . LYS A 1 302 ? 21.850  12.760  13.591 1.00 116.94 ? 304  LYS A CA    1 ? 
ATOM   2331 C C     . LYS A 1 302 ? 20.809  11.837  14.226 1.00 123.09 ? 304  LYS A C     1 ? 
ATOM   2332 O O     . LYS A 1 302 ? 19.933  11.309  13.479 1.00 130.88 ? 304  LYS A O     1 ? 
ATOM   2333 C CB    . LYS A 1 302 ? 21.415  13.231  12.200 1.00 116.88 ? 304  LYS A CB    1 ? 
ATOM   2334 C CG    . LYS A 1 302 ? 21.746  12.261  11.067 1.00 115.37 ? 304  LYS A CG    1 ? 
ATOM   2335 C CD    . LYS A 1 302 ? 21.068  12.607  9.766  1.00 114.17 ? 304  LYS A CD    1 ? 
ATOM   2336 C CE    . LYS A 1 302 ? 22.055  13.029  8.700  1.00 116.98 ? 304  LYS A CE    1 ? 
ATOM   2337 N NZ    . LYS A 1 302 ? 21.370  13.501  7.472  1.00 114.08 ? 304  LYS A NZ    1 ? 
ATOM   2338 N N     . GLU A 1 303 ? 20.912  11.620  15.539 1.00 100.77 ? 305  GLU A N     1 ? 
ATOM   2339 C CA    . GLU A 1 303 ? 20.027  10.649  16.233 1.00 97.21  ? 305  GLU A CA    1 ? 
ATOM   2340 C C     . GLU A 1 303 ? 19.636  11.207  17.589 1.00 86.58  ? 305  GLU A C     1 ? 
ATOM   2341 O O     . GLU A 1 303 ? 20.484  11.593  18.388 1.00 80.99  ? 305  GLU A O     1 ? 
ATOM   2342 C CB    . GLU A 1 303 ? 20.690  9.280   16.403 1.00 102.14 ? 305  GLU A CB    1 ? 
ATOM   2343 C CG    . GLU A 1 303 ? 19.726  8.192   16.855 1.00 94.84  ? 305  GLU A CG    1 ? 
ATOM   2344 C CD    . GLU A 1 303 ? 19.967  6.832   16.211 1.00 94.52  ? 305  GLU A CD    1 ? 
ATOM   2345 O OE1   . GLU A 1 303 ? 19.018  6.038   16.141 1.00 102.76 ? 305  GLU A OE1   1 ? 
ATOM   2346 O OE2   . GLU A 1 303 ? 21.098  6.559   15.780 1.00 88.15  ? 305  GLU A OE2   1 ? 
ATOM   2347 N N     . PRO A 1 304 ? 18.328  11.236  17.897 1.00 86.75  ? 306  PRO A N     1 ? 
ATOM   2348 C CA    . PRO A 1 304 ? 17.861  11.724  19.189 1.00 88.27  ? 306  PRO A CA    1 ? 
ATOM   2349 C C     . PRO A 1 304 ? 18.084  10.716  20.328 1.00 87.13  ? 306  PRO A C     1 ? 
ATOM   2350 O O     . PRO A 1 304 ? 17.167  10.465  21.099 1.00 86.10  ? 306  PRO A O     1 ? 
ATOM   2351 C CB    . PRO A 1 304 ? 16.361  11.988  18.967 1.00 83.70  ? 306  PRO A CB    1 ? 
ATOM   2352 C CG    . PRO A 1 304 ? 16.149  11.866  17.476 1.00 89.37  ? 306  PRO A CG    1 ? 
ATOM   2353 C CD    . PRO A 1 304 ? 17.218  10.920  16.987 1.00 95.34  ? 306  PRO A CD    1 ? 
ATOM   2354 N N     . ILE A 1 305 ? 19.295  10.171  20.430 1.00 84.07  ? 307  ILE A N     1 ? 
ATOM   2355 C CA    . ILE A 1 305 ? 19.693  9.325   21.591 1.00 82.76  ? 307  ILE A CA    1 ? 
ATOM   2356 C C     . ILE A 1 305 ? 21.064  9.760   22.089 1.00 74.76  ? 307  ILE A C     1 ? 
ATOM   2357 O O     . ILE A 1 305 ? 21.893  10.209  21.280 1.00 73.57  ? 307  ILE A O     1 ? 
ATOM   2358 C CB    . ILE A 1 305 ? 19.697  7.838   21.233 1.00 76.88  ? 307  ILE A CB    1 ? 
ATOM   2359 C CG1   . ILE A 1 305 ? 20.810  7.520   20.244 1.00 78.96  ? 307  ILE A CG1   1 ? 
ATOM   2360 C CG2   . ILE A 1 305 ? 18.345  7.411   20.701 1.00 84.08  ? 307  ILE A CG2   1 ? 
ATOM   2361 C CD1   . ILE A 1 305 ? 21.170  6.067   20.182 1.00 84.37  ? 307  ILE A CD1   1 ? 
ATOM   2362 N N     . GLY A 1 306 ? 21.283  9.600   23.385 1.00 70.65  ? 308  GLY A N     1 ? 
ATOM   2363 C CA    . GLY A 1 306 ? 22.528  10.051  24.024 1.00 77.92  ? 308  GLY A CA    1 ? 
ATOM   2364 C C     . GLY A 1 306 ? 23.699  9.156   23.676 1.00 73.55  ? 308  GLY A C     1 ? 
ATOM   2365 O O     . GLY A 1 306 ? 23.508  8.092   23.053 1.00 73.26  ? 308  GLY A O     1 ? 
ATOM   2366 N N     . LEU A 1 307 ? 24.897  9.596   24.033 1.00 76.12  ? 309  LEU A N     1 ? 
ATOM   2367 C CA    . LEU A 1 307 ? 26.129  8.827   23.753 1.00 76.95  ? 309  LEU A CA    1 ? 
ATOM   2368 C C     . LEU A 1 307 ? 26.831  8.540   25.067 1.00 71.38  ? 309  LEU A C     1 ? 
ATOM   2369 O O     . LEU A 1 307 ? 26.825  9.417   25.939 1.00 73.08  ? 309  LEU A O     1 ? 
ATOM   2370 C CB    . LEU A 1 307 ? 27.060  9.593   22.813 1.00 79.61  ? 309  LEU A CB    1 ? 
ATOM   2371 C CG    . LEU A 1 307 ? 26.422  10.213  21.576 1.00 77.01  ? 309  LEU A CG    1 ? 
ATOM   2372 C CD1   . LEU A 1 307 ? 26.049  11.654  21.832 1.00 70.87  ? 309  LEU A CD1   1 ? 
ATOM   2373 C CD2   . LEU A 1 307 ? 27.369  10.114  20.390 1.00 83.82  ? 309  LEU A CD2   1 ? 
ATOM   2374 N N     . LEU A 1 308 ? 27.369  7.329   25.180 1.00 67.55  ? 310  LEU A N     1 ? 
ATOM   2375 C CA    . LEU A 1 308 ? 28.074  6.887   26.396 1.00 71.36  ? 310  LEU A CA    1 ? 
ATOM   2376 C C     . LEU A 1 308 ? 29.535  7.238   26.195 1.00 69.12  ? 310  LEU A C     1 ? 
ATOM   2377 O O     . LEU A 1 308 ? 30.119  6.783   25.206 1.00 69.03  ? 310  LEU A O     1 ? 
ATOM   2378 C CB    . LEU A 1 308 ? 27.882  5.386   26.621 1.00 66.21  ? 310  LEU A CB    1 ? 
ATOM   2379 C CG    . LEU A 1 308 ? 28.547  4.855   27.883 1.00 65.47  ? 310  LEU A CG    1 ? 
ATOM   2380 C CD1   . LEU A 1 308 ? 27.922  5.458   29.122 1.00 65.29  ? 310  LEU A CD1   1 ? 
ATOM   2381 C CD2   . LEU A 1 308 ? 28.466  3.349   27.927 1.00 71.97  ? 310  LEU A CD2   1 ? 
ATOM   2382 N N     . CYS A 1 309 ? 30.086  8.026   27.107 1.00 76.41  ? 311  CYS A N     1 ? 
ATOM   2383 C CA    . CYS A 1 309 ? 31.459  8.543   26.957 1.00 74.65  ? 311  CYS A CA    1 ? 
ATOM   2384 C C     . CYS A 1 309 ? 32.171  8.508   28.295 1.00 83.16  ? 311  CYS A C     1 ? 
ATOM   2385 O O     . CYS A 1 309 ? 31.509  8.487   29.336 1.00 95.58  ? 311  CYS A O     1 ? 
ATOM   2386 C CB    . CYS A 1 309 ? 31.464  9.956   26.388 1.00 77.89  ? 311  CYS A CB    1 ? 
ATOM   2387 S SG    . CYS A 1 309 ? 30.414  10.197  24.937 1.00 80.48  ? 311  CYS A SG    1 ? 
ATOM   2388 N N     . ARG A 1 310 ? 33.491  8.485   28.236 1.00 90.84  ? 312  ARG A N     1 ? 
ATOM   2389 C CA    . ARG A 1 310 ? 34.336  8.790   29.412 1.00 89.79  ? 312  ARG A CA    1 ? 
ATOM   2390 C C     . ARG A 1 310 ? 34.551  10.296  29.422 1.00 83.20  ? 312  ARG A C     1 ? 
ATOM   2391 O O     . ARG A 1 310 ? 35.052  10.810  28.406 1.00 89.06  ? 312  ARG A O     1 ? 
ATOM   2392 C CB    . ARG A 1 310 ? 35.659  8.037   29.303 1.00 92.53  ? 312  ARG A CB    1 ? 
ATOM   2393 C CG    . ARG A 1 310 ? 36.277  7.662   30.640 1.00 95.76  ? 312  ARG A CG    1 ? 
ATOM   2394 C CD    . ARG A 1 310 ? 37.707  7.200   30.452 1.00 87.12  ? 312  ARG A CD    1 ? 
ATOM   2395 N NE    . ARG A 1 310 ? 38.334  6.813   31.704 1.00 95.85  ? 312  ARG A NE    1 ? 
ATOM   2396 C CZ    . ARG A 1 310 ? 39.567  6.319   31.822 1.00 90.30  ? 312  ARG A CZ    1 ? 
ATOM   2397 N NH1   . ARG A 1 310 ? 40.321  6.131   30.754 1.00 83.27  ? 312  ARG A NH1   1 ? 
ATOM   2398 N NH2   . ARG A 1 310 ? 40.036  5.995   33.014 1.00 82.07  ? 312  ARG A NH2   1 ? 
ATOM   2399 N N     . THR A 1 311 ? 34.161  10.965  30.501 1.00 82.71  ? 313  THR A N     1 ? 
ATOM   2400 C CA    . THR A 1 311 ? 34.133  12.445  30.538 1.00 90.79  ? 313  THR A CA    1 ? 
ATOM   2401 C C     . THR A 1 311 ? 34.904  12.959  31.744 1.00 100.63 ? 313  THR A C     1 ? 
ATOM   2402 O O     . THR A 1 311 ? 34.942  12.265  32.789 1.00 99.59  ? 313  THR A O     1 ? 
ATOM   2403 C CB    . THR A 1 311 ? 32.699  12.978  30.552 1.00 91.65  ? 313  THR A CB    1 ? 
ATOM   2404 O OG1   . THR A 1 311 ? 32.078  12.545  31.768 1.00 83.89  ? 313  THR A OG1   1 ? 
ATOM   2405 C CG2   . THR A 1 311 ? 31.933  12.504  29.337 1.00 94.16  ? 313  THR A CG2   1 ? 
ATOM   2406 N N     . LYS A 1 312 ? 35.504  14.132  31.558 1.00 111.07 ? 314  LYS A N     1 ? 
ATOM   2407 C CA    . LYS A 1 312 ? 35.987  15.012  32.646 1.00 104.49 ? 314  LYS A CA    1 ? 
ATOM   2408 C C     . LYS A 1 312 ? 35.500  16.411  32.308 1.00 97.68  ? 314  LYS A C     1 ? 
ATOM   2409 O O     . LYS A 1 312 ? 35.896  16.926  31.248 1.00 96.37  ? 314  LYS A O     1 ? 
ATOM   2410 C CB    . LYS A 1 312 ? 37.510  14.956  32.753 1.00 112.57 ? 314  LYS A CB    1 ? 
ATOM   2411 C CG    . LYS A 1 312 ? 38.071  13.602  33.169 1.00 121.03 ? 314  LYS A CG    1 ? 
ATOM   2412 C CD    . LYS A 1 312 ? 39.475  13.367  32.661 1.00 116.84 ? 314  LYS A CD    1 ? 
ATOM   2413 C CE    . LYS A 1 312 ? 40.498  14.231  33.366 1.00 116.66 ? 314  LYS A CE    1 ? 
ATOM   2414 N NZ    . LYS A 1 312 ? 41.852  14.063  32.779 1.00 111.95 ? 314  LYS A NZ    1 ? 
ATOM   2415 N N     . LYS A 1 313 ? 34.621  16.961  33.137 1.00 102.77 ? 315  LYS A N     1 ? 
ATOM   2416 C CA    . LYS A 1 313 ? 34.044  18.299  32.876 1.00 115.03 ? 315  LYS A CA    1 ? 
ATOM   2417 C C     . LYS A 1 313 ? 35.093  19.382  33.144 1.00 124.73 ? 315  LYS A C     1 ? 
ATOM   2418 O O     . LYS A 1 313 ? 35.125  20.374  32.364 1.00 123.56 ? 315  LYS A O     1 ? 
ATOM   2419 C CB    . LYS A 1 313 ? 32.804  18.530  33.732 1.00 108.11 ? 315  LYS A CB    1 ? 
ATOM   2420 C CG    . LYS A 1 313 ? 32.203  19.915  33.562 1.00 115.28 ? 315  LYS A CG    1 ? 
ATOM   2421 C CD    . LYS A 1 313 ? 30.716  19.919  33.749 1.00 121.02 ? 315  LYS A CD    1 ? 
ATOM   2422 C CE    . LYS A 1 313 ? 29.999  19.314  32.557 1.00 122.79 ? 315  LYS A CE    1 ? 
ATOM   2423 N NZ    . LYS A 1 313 ? 28.523  19.457  32.658 1.00 124.37 ? 315  LYS A NZ    1 ? 
ATOM   2424 N N     . ASN A 1 314 ? 35.892  19.208  34.201 1.00 118.40 ? 316  ASN A N     1 ? 
ATOM   2425 C CA    . ASN A 1 314 ? 36.952  20.175  34.592 1.00 118.26 ? 316  ASN A CA    1 ? 
ATOM   2426 C C     . ASN A 1 314 ? 38.305  19.469  34.627 1.00 126.15 ? 316  ASN A C     1 ? 
ATOM   2427 O O     . ASN A 1 314 ? 38.336  18.233  34.818 1.00 132.49 ? 316  ASN A O     1 ? 
ATOM   2428 C CB    . ASN A 1 314 ? 36.645  20.835  35.931 1.00 106.50 ? 316  ASN A CB    1 ? 
ATOM   2429 C CG    . ASN A 1 314 ? 35.315  21.551  35.911 1.00 106.00 ? 316  ASN A CG    1 ? 
ATOM   2430 O OD1   . ASN A 1 314 ? 34.835  21.959  34.854 1.00 98.61  ? 316  ASN A OD1   1 ? 
ATOM   2431 N ND2   . ASN A 1 314 ? 34.704  21.689  37.075 1.00 110.52 ? 316  ASN A ND2   1 ? 
ATOM   2432 N N     . SER A 1 315 ? 39.381  20.238  34.459 1.00 115.40 ? 317  SER A N     1 ? 
ATOM   2433 C CA    . SER A 1 315 ? 40.740  19.679  34.251 1.00 113.13 ? 317  SER A CA    1 ? 
ATOM   2434 C C     . SER A 1 315 ? 41.182  18.850  35.454 1.00 110.82 ? 317  SER A C     1 ? 
ATOM   2435 O O     . SER A 1 315 ? 41.962  17.903  35.237 1.00 111.07 ? 317  SER A O     1 ? 
ATOM   2436 C CB    . SER A 1 315 ? 41.722  20.767  33.972 1.00 114.34 ? 317  SER A CB    1 ? 
ATOM   2437 O OG    . SER A 1 315 ? 42.951  20.212  33.531 1.00 116.30 ? 317  SER A OG    1 ? 
ATOM   2438 N N     . GLY A 1 316 ? 40.720  19.198  36.658 1.00 105.67 ? 318  GLY A N     1 ? 
ATOM   2439 C CA    . GLY A 1 316 ? 41.098  18.479  37.890 1.00 102.19 ? 318  GLY A CA    1 ? 
ATOM   2440 C C     . GLY A 1 316 ? 40.168  17.323  38.190 1.00 108.33 ? 318  GLY A C     1 ? 
ATOM   2441 O O     . GLY A 1 316 ? 40.543  16.498  39.040 1.00 105.32 ? 318  GLY A O     1 ? 
ATOM   2442 N N     . ASP A 1 317 ? 39.011  17.257  37.519 1.00 112.63 ? 319  ASP A N     1 ? 
ATOM   2443 C CA    . ASP A 1 317 ? 37.965  16.236  37.792 1.00 103.27 ? 319  ASP A CA    1 ? 
ATOM   2444 C C     . ASP A 1 317 ? 38.473  14.848  37.402 1.00 102.10 ? 319  ASP A C     1 ? 
ATOM   2445 O O     . ASP A 1 317 ? 39.256  14.683  36.464 1.00 94.00  ? 319  ASP A O     1 ? 
ATOM   2446 C CB    . ASP A 1 317 ? 36.657  16.574  37.074 1.00 104.08 ? 319  ASP A CB    1 ? 
ATOM   2447 C CG    . ASP A 1 317 ? 35.751  17.528  37.838 1.00 103.66 ? 319  ASP A CG    1 ? 
ATOM   2448 O OD1   . ASP A 1 317 ? 35.674  17.409  39.087 1.00 101.33 ? 319  ASP A OD1   1 ? 
ATOM   2449 O OD2   . ASP A 1 317 ? 35.108  18.363  37.174 1.00 98.37  ? 319  ASP A OD2   1 ? 
ATOM   2450 N N     . PRO A 1 318 ? 38.034  13.791  38.123 1.00 103.24 ? 320  PRO A N     1 ? 
ATOM   2451 C CA    . PRO A 1 318 ? 38.370  12.425  37.747 1.00 93.44  ? 320  PRO A CA    1 ? 
ATOM   2452 C C     . PRO A 1 318 ? 37.513  11.953  36.570 1.00 86.24  ? 320  PRO A C     1 ? 
ATOM   2453 O O     . PRO A 1 318 ? 36.507  12.566  36.273 1.00 96.72  ? 320  PRO A O     1 ? 
ATOM   2454 C CB    . PRO A 1 318 ? 38.060  11.583  38.997 1.00 89.11  ? 320  PRO A CB    1 ? 
ATOM   2455 C CG    . PRO A 1 318 ? 37.621  12.569  40.064 1.00 92.14  ? 320  PRO A CG    1 ? 
ATOM   2456 C CD    . PRO A 1 318 ? 37.195  13.828  39.333 1.00 103.57 ? 320  PRO A CD    1 ? 
ATOM   2457 N N     . TRP A 1 319 ? 37.952  10.871  35.940 1.00 84.90  ? 321  TRP A N     1 ? 
ATOM   2458 C CA    . TRP A 1 319 ? 37.227  10.226  34.822 1.00 96.37  ? 321  TRP A CA    1 ? 
ATOM   2459 C C     . TRP A 1 319 ? 35.861  9.741   35.314 1.00 104.81 ? 321  TRP A C     1 ? 
ATOM   2460 O O     . TRP A 1 319 ? 35.790  9.105   36.399 1.00 105.71 ? 321  TRP A O     1 ? 
ATOM   2461 C CB    . TRP A 1 319 ? 38.029  9.051   34.269 1.00 102.28 ? 321  TRP A CB    1 ? 
ATOM   2462 C CG    . TRP A 1 319 ? 39.092  9.408   33.280 1.00 101.42 ? 321  TRP A CG    1 ? 
ATOM   2463 C CD1   . TRP A 1 319 ? 40.422  9.129   33.384 1.00 101.26 ? 321  TRP A CD1   1 ? 
ATOM   2464 C CD2   . TRP A 1 319 ? 38.915  10.054  32.007 1.00 99.86  ? 321  TRP A CD2   1 ? 
ATOM   2465 N NE1   . TRP A 1 319 ? 41.088  9.566   32.273 1.00 102.95 ? 321  TRP A NE1   1 ? 
ATOM   2466 C CE2   . TRP A 1 319 ? 40.192  10.139  31.410 1.00 102.17 ? 321  TRP A CE2   1 ? 
ATOM   2467 C CE3   . TRP A 1 319 ? 37.817  10.586  31.324 1.00 99.43  ? 321  TRP A CE3   1 ? 
ATOM   2468 C CZ2   . TRP A 1 319 ? 40.396  10.729  30.164 1.00 96.95  ? 321  TRP A CZ2   1 ? 
ATOM   2469 C CZ3   . TRP A 1 319 ? 38.018  11.164  30.089 1.00 100.07 ? 321  TRP A CZ3   1 ? 
ATOM   2470 C CH2   . TRP A 1 319 ? 39.291  11.233  29.518 1.00 99.88  ? 321  TRP A CH2   1 ? 
ATOM   2471 N N     . LEU A 1 320 ? 34.819  10.016  34.536 1.00 97.01  ? 322  LEU A N     1 ? 
ATOM   2472 C CA    . LEU A 1 320 ? 33.447  9.558   34.848 1.00 85.71  ? 322  LEU A CA    1 ? 
ATOM   2473 C C     . LEU A 1 320 ? 32.850  8.973   33.584 1.00 83.66  ? 322  LEU A C     1 ? 
ATOM   2474 O O     . LEU A 1 320 ? 32.813  9.688   32.561 1.00 80.02  ? 322  LEU A O     1 ? 
ATOM   2475 C CB    . LEU A 1 320 ? 32.610  10.733  35.351 1.00 82.37  ? 322  LEU A CB    1 ? 
ATOM   2476 C CG    . LEU A 1 320 ? 32.485  10.856  36.863 1.00 78.41  ? 322  LEU A CG    1 ? 
ATOM   2477 C CD1   . LEU A 1 320 ? 31.587  12.023  37.212 1.00 80.50  ? 322  LEU A CD1   1 ? 
ATOM   2478 C CD2   . LEU A 1 320 ? 31.940  9.579   37.478 1.00 76.48  ? 322  LEU A CD2   1 ? 
ATOM   2479 N N     . VAL A 1 321 ? 32.424  7.717   33.659 1.00 85.46  ? 323  VAL A N     1 ? 
ATOM   2480 C CA    . VAL A 1 321 ? 31.702  7.069   32.534 1.00 78.46  ? 323  VAL A CA    1 ? 
ATOM   2481 C C     . VAL A 1 321 ? 30.228  7.421   32.676 1.00 77.62  ? 323  VAL A C     1 ? 
ATOM   2482 O O     . VAL A 1 321 ? 29.614  7.049   33.700 1.00 80.40  ? 323  VAL A O     1 ? 
ATOM   2483 C CB    . VAL A 1 321 ? 31.928  5.558   32.496 1.00 77.61  ? 323  VAL A CB    1 ? 
ATOM   2484 C CG1   . VAL A 1 321 ? 31.195  4.951   31.312 1.00 83.28  ? 323  VAL A CG1   1 ? 
ATOM   2485 C CG2   . VAL A 1 321 ? 33.408  5.231   32.437 1.00 81.54  ? 323  VAL A CG2   1 ? 
ATOM   2486 N N     . ALA A 1 322 ? 29.695  8.141   31.699 1.00 70.47  ? 324  ALA A N     1 ? 
ATOM   2487 C CA    . ALA A 1 322 ? 28.339  8.707   31.795 1.00 66.14  ? 324  ALA A CA    1 ? 
ATOM   2488 C C     . ALA A 1 322 ? 27.750  8.965   30.411 1.00 70.84  ? 324  ALA A C     1 ? 
ATOM   2489 O O     . ALA A 1 322 ? 28.441  8.852   29.381 1.00 75.55  ? 324  ALA A O     1 ? 
ATOM   2490 C CB    . ALA A 1 322 ? 28.381  9.966   32.614 1.00 72.21  ? 324  ALA A CB    1 ? 
ATOM   2491 N N     . ASN A 1 323 ? 26.475  9.286   30.408 1.00 70.33  ? 325  ASN A N     1 ? 
ATOM   2492 C CA    . ASN A 1 323 ? 25.728  9.547   29.163 1.00 74.72  ? 325  ASN A CA    1 ? 
ATOM   2493 C C     . ASN A 1 323 ? 25.764  11.049  28.922 1.00 74.39  ? 325  ASN A C     1 ? 
ATOM   2494 O O     . ASN A 1 323 ? 25.522  11.811  29.891 1.00 77.52  ? 325  ASN A O     1 ? 
ATOM   2495 C CB    . ASN A 1 323 ? 24.300  8.998   29.253 1.00 66.46  ? 325  ASN A CB    1 ? 
ATOM   2496 C CG    . ASN A 1 323 ? 23.401  9.529   28.167 1.00 62.04  ? 325  ASN A CG    1 ? 
ATOM   2497 O OD1   . ASN A 1 323 ? 23.518  9.123   27.013 1.00 70.37  ? 325  ASN A OD1   1 ? 
ATOM   2498 N ND2   . ASN A 1 323 ? 22.498  10.434  28.520 1.00 65.73  ? 325  ASN A ND2   1 ? 
ATOM   2499 N N     . VAL A 1 324 ? 25.997  11.429  27.671 1.00 69.90  ? 326  VAL A N     1 ? 
ATOM   2500 C CA    . VAL A 1 324 ? 25.837  12.833  27.223 1.00 75.56  ? 326  VAL A CA    1 ? 
ATOM   2501 C C     . VAL A 1 324 ? 24.660  12.858  26.266 1.00 72.30  ? 326  VAL A C     1 ? 
ATOM   2502 O O     . VAL A 1 324 ? 24.740  12.166  25.249 1.00 71.64  ? 326  VAL A O     1 ? 
ATOM   2503 C CB    . VAL A 1 324 ? 27.128  13.362  26.581 1.00 77.03  ? 326  VAL A CB    1 ? 
ATOM   2504 C CG1   . VAL A 1 324 ? 26.999  14.828  26.214 1.00 76.72  ? 326  VAL A CG1   1 ? 
ATOM   2505 C CG2   . VAL A 1 324 ? 28.312  13.133  27.505 1.00 81.10  ? 326  VAL A CG2   1 ? 
ATOM   2506 N N     . GLU A 1 325 ? 23.641  13.651  26.591 1.00 77.04  ? 327  GLU A N     1 ? 
ATOM   2507 C CA    . GLU A 1 325 ? 22.415  13.750  25.764 1.00 84.96  ? 327  GLU A CA    1 ? 
ATOM   2508 C C     . GLU A 1 325 ? 22.744  14.347  24.396 1.00 87.59  ? 327  GLU A C     1 ? 
ATOM   2509 O O     . GLU A 1 325 ? 23.785  15.000  24.237 1.00 97.80  ? 327  GLU A O     1 ? 
ATOM   2510 C CB    . GLU A 1 325 ? 21.334  14.573  26.463 1.00 84.43  ? 327  GLU A CB    1 ? 
ATOM   2511 C CG    . GLU A 1 325 ? 20.532  13.781  27.484 1.00 77.11  ? 327  GLU A CG    1 ? 
ATOM   2512 C CD    . GLU A 1 325 ? 19.699  12.629  26.929 1.00 76.30  ? 327  GLU A CD    1 ? 
ATOM   2513 O OE1   . GLU A 1 325 ? 18.456  12.671  27.055 1.00 70.26  ? 327  GLU A OE1   1 ? 
ATOM   2514 O OE2   . GLU A 1 325 ? 20.291  11.682  26.382 1.00 76.33  ? 327  GLU A OE2   1 ? 
ATOM   2515 N N     . TYR A 1 326 ? 21.854  14.124  23.443 1.00 91.03  ? 328  TYR A N     1 ? 
ATOM   2516 C CA    . TYR A 1 326 ? 22.103  14.394  22.005 1.00 94.99  ? 328  TYR A CA    1 ? 
ATOM   2517 C C     . TYR A 1 326 ? 22.407  15.879  21.802 1.00 92.17  ? 328  TYR A C     1 ? 
ATOM   2518 O O     . TYR A 1 326 ? 23.399  16.179  21.100 1.00 93.28  ? 328  TYR A O     1 ? 
ATOM   2519 C CB    . TYR A 1 326 ? 20.917  13.932  21.153 1.00 94.40  ? 328  TYR A CB    1 ? 
ATOM   2520 C CG    . TYR A 1 326 ? 19.558  14.091  21.791 1.00 97.52  ? 328  TYR A CG    1 ? 
ATOM   2521 C CD1   . TYR A 1 326 ? 19.034  13.096  22.610 1.00 102.34 ? 328  TYR A CD1   1 ? 
ATOM   2522 C CD2   . TYR A 1 326 ? 18.787  15.227  21.582 1.00 101.25 ? 328  TYR A CD2   1 ? 
ATOM   2523 C CE1   . TYR A 1 326 ? 17.787  13.227  23.209 1.00 107.25 ? 328  TYR A CE1   1 ? 
ATOM   2524 C CE2   . TYR A 1 326 ? 17.536  15.372  22.167 1.00 99.86  ? 328  TYR A CE2   1 ? 
ATOM   2525 C CZ    . TYR A 1 326 ? 17.029  14.369  22.984 1.00 105.03 ? 328  TYR A CZ    1 ? 
ATOM   2526 O OH    . TYR A 1 326 ? 15.793  14.480  23.573 1.00 92.23  ? 328  TYR A OH    1 ? 
ATOM   2527 N N     . ASN A 1 327 ? 21.579  16.753  22.378 1.00 92.68  ? 329  ASN A N     1 ? 
ATOM   2528 C CA    . ASN A 1 327 ? 21.696  18.226  22.202 1.00 99.35  ? 329  ASN A CA    1 ? 
ATOM   2529 C C     . ASN A 1 327 ? 23.048  18.690  22.739 1.00 95.19  ? 329  ASN A C     1 ? 
ATOM   2530 O O     . ASN A 1 327 ? 23.730  19.451  22.027 1.00 103.85 ? 329  ASN A O     1 ? 
ATOM   2531 C CB    . ASN A 1 327 ? 20.548  18.980  22.873 1.00 101.92 ? 329  ASN A CB    1 ? 
ATOM   2532 C CG    . ASN A 1 327 ? 19.953  18.238  24.053 1.00 103.01 ? 329  ASN A CG    1 ? 
ATOM   2533 O OD1   . ASN A 1 327 ? 20.641  17.486  24.747 1.00 107.75 ? 329  ASN A OD1   1 ? 
ATOM   2534 N ND2   . ASN A 1 327 ? 18.667  18.437  24.291 1.00 103.83 ? 329  ASN A ND2   1 ? 
ATOM   2535 N N     . VAL A 1 328 ? 23.421  18.224  23.927 1.00 85.04  ? 330  VAL A N     1 ? 
ATOM   2536 C CA    . VAL A 1 328 ? 24.701  18.612  24.580 1.00 84.40  ? 330  VAL A CA    1 ? 
ATOM   2537 C C     . VAL A 1 328 ? 25.859  18.184  23.681 1.00 84.85  ? 330  VAL A C     1 ? 
ATOM   2538 O O     . VAL A 1 328 ? 26.816  18.952  23.565 1.00 91.56  ? 330  VAL A O     1 ? 
ATOM   2539 C CB    . VAL A 1 328 ? 24.822  17.999  25.985 1.00 78.61  ? 330  VAL A CB    1 ? 
ATOM   2540 C CG1   . VAL A 1 328 ? 26.165  18.319  26.607 1.00 82.01  ? 330  VAL A CG1   1 ? 
ATOM   2541 C CG2   . VAL A 1 328 ? 23.694  18.476  26.878 1.00 79.88  ? 330  VAL A CG2   1 ? 
ATOM   2542 N N     . PHE A 1 329 ? 25.791  16.995  23.092 1.00 91.08  ? 331  PHE A N     1 ? 
ATOM   2543 C CA    . PHE A 1 329 ? 26.897  16.491  22.243 1.00 98.28  ? 331  PHE A CA    1 ? 
ATOM   2544 C C     . PHE A 1 329 ? 26.928  17.243  20.915 1.00 99.68  ? 331  PHE A C     1 ? 
ATOM   2545 O O     . PHE A 1 329 ? 28.038  17.380  20.358 1.00 97.86  ? 331  PHE A O     1 ? 
ATOM   2546 C CB    . PHE A 1 329 ? 26.778  15.002  21.957 1.00 93.98  ? 331  PHE A CB    1 ? 
ATOM   2547 C CG    . PHE A 1 329 ? 27.999  14.459  21.267 1.00 91.15  ? 331  PHE A CG    1 ? 
ATOM   2548 C CD1   . PHE A 1 329 ? 29.197  14.345  21.951 1.00 88.24  ? 331  PHE A CD1   1 ? 
ATOM   2549 C CD2   . PHE A 1 329 ? 27.959  14.105  19.929 1.00 92.38  ? 331  PHE A CD2   1 ? 
ATOM   2550 C CE1   . PHE A 1 329 ? 30.328  13.860  21.319 1.00 83.28  ? 331  PHE A CE1   1 ? 
ATOM   2551 C CE2   . PHE A 1 329 ? 29.092  13.622  19.299 1.00 86.80  ? 331  PHE A CE2   1 ? 
ATOM   2552 C CZ    . PHE A 1 329 ? 30.271  13.500  19.996 1.00 85.99  ? 331  PHE A CZ    1 ? 
ATOM   2553 N N     . ALA A 1 330 ? 25.771  17.681  20.412 1.00 100.13 ? 332  ALA A N     1 ? 
ATOM   2554 C CA    . ALA A 1 330 ? 25.707  18.537  19.203 1.00 112.13 ? 332  ALA A CA    1 ? 
ATOM   2555 C C     . ALA A 1 330 ? 26.417  19.872  19.485 1.00 121.46 ? 332  ALA A C     1 ? 
ATOM   2556 O O     . ALA A 1 330 ? 27.242  20.311  18.621 1.00 119.25 ? 332  ALA A O     1 ? 
ATOM   2557 C CB    . ALA A 1 330 ? 24.280  18.750  18.760 1.00 97.63  ? 332  ALA A CB    1 ? 
ATOM   2558 N N     . GLU A 1 331 ? 26.134  20.481  20.644 1.00 111.96 ? 333  GLU A N     1 ? 
ATOM   2559 C CA    . GLU A 1 331 ? 26.760  21.765  21.061 1.00 112.24 ? 333  GLU A CA    1 ? 
ATOM   2560 C C     . GLU A 1 331 ? 28.272  21.580  21.210 1.00 105.32 ? 333  GLU A C     1 ? 
ATOM   2561 O O     . GLU A 1 331 ? 29.008  22.464  20.729 1.00 105.25 ? 333  GLU A O     1 ? 
ATOM   2562 C CB    . GLU A 1 331 ? 26.150  22.272  22.364 1.00 110.12 ? 333  GLU A CB    1 ? 
ATOM   2563 C CG    . GLU A 1 331 ? 26.589  23.679  22.721 1.00 116.71 ? 333  GLU A CG    1 ? 
ATOM   2564 C CD    . GLU A 1 331 ? 25.900  24.225  23.960 1.00 118.40 ? 333  GLU A CD    1 ? 
ATOM   2565 O OE1   . GLU A 1 331 ? 25.097  23.470  24.563 1.00 105.75 ? 333  GLU A OE1   1 ? 
ATOM   2566 O OE2   . GLU A 1 331 ? 26.182  25.400  24.329 1.00 119.68 ? 333  GLU A OE2   1 ? 
ATOM   2567 N N     . VAL A 1 332 ? 28.700  20.476  21.830 1.00 104.72 ? 334  VAL A N     1 ? 
ATOM   2568 C CA    . VAL A 1 332 ? 30.147  20.165  22.042 1.00 114.78 ? 334  VAL A CA    1 ? 
ATOM   2569 C C     . VAL A 1 332 ? 30.847  19.955  20.690 1.00 123.16 ? 334  VAL A C     1 ? 
ATOM   2570 O O     . VAL A 1 332 ? 32.022  20.404  20.562 1.00 115.89 ? 334  VAL A O     1 ? 
ATOM   2571 C CB    . VAL A 1 332 ? 30.347  18.946  22.959 1.00 105.99 ? 334  VAL A CB    1 ? 
ATOM   2572 C CG1   . VAL A 1 332 ? 31.810  18.529  22.997 1.00 111.57 ? 334  VAL A CG1   1 ? 
ATOM   2573 C CG2   . VAL A 1 332 ? 29.844  19.227  24.360 1.00 108.18 ? 334  VAL A CG2   1 ? 
ATOM   2574 N N     . SER A 1 333 ? 30.189  19.276  19.741 1.00 123.95 ? 335  SER A N     1 ? 
ATOM   2575 C CA    . SER A 1 333 ? 30.768  18.992  18.398 1.00 123.23 ? 335  SER A CA    1 ? 
ATOM   2576 C C     . SER A 1 333 ? 30.943  20.293  17.609 1.00 121.92 ? 335  SER A C     1 ? 
ATOM   2577 O O     . SER A 1 333 ? 31.958  20.417  16.872 1.00 116.33 ? 335  SER A O     1 ? 
ATOM   2578 C CB    . SER A 1 333 ? 29.924  18.026  17.618 1.00 109.75 ? 335  SER A CB    1 ? 
ATOM   2579 O OG    . SER A 1 333 ? 28.571  18.445  17.566 1.00 102.08 ? 335  SER A OG    1 ? 
ATOM   2580 N N     . ARG A 1 334 ? 29.995  21.223  17.751 1.00 121.24 ? 336  ARG A N     1 ? 
ATOM   2581 C CA    . ARG A 1 334 ? 30.094  22.532  17.053 1.00 117.55 ? 336  ARG A CA    1 ? 
ATOM   2582 C C     . ARG A 1 334 ? 31.330  23.274  17.571 1.00 115.60 ? 336  ARG A C     1 ? 
ATOM   2583 O O     . ARG A 1 334 ? 31.990  23.959  16.764 1.00 103.07 ? 336  ARG A O     1 ? 
ATOM   2584 C CB    . ARG A 1 334 ? 28.821  23.354  17.278 1.00 115.39 ? 336  ARG A CB    1 ? 
ATOM   2585 C CG    . ARG A 1 334 ? 28.811  24.686  16.544 1.00 126.49 ? 336  ARG A CG    1 ? 
ATOM   2586 C CD    . ARG A 1 334 ? 28.960  24.500  15.046 1.00 128.95 ? 336  ARG A CD    1 ? 
ATOM   2587 N NE    . ARG A 1 334 ? 29.305  25.739  14.365 1.00 129.85 ? 336  ARG A NE    1 ? 
ATOM   2588 C CZ    . ARG A 1 334 ? 30.548  26.138  14.116 1.00 126.66 ? 336  ARG A CZ    1 ? 
ATOM   2589 N NH1   . ARG A 1 334 ? 31.571  25.389  14.490 1.00 118.57 ? 336  ARG A NH1   1 ? 
ATOM   2590 N NH2   . ARG A 1 334 ? 30.762  27.282  13.491 1.00 120.69 ? 336  ARG A NH2   1 ? 
ATOM   2591 N N     . ALA A 1 335 ? 31.636  23.127  18.864 1.00 132.70 ? 337  ALA A N     1 ? 
ATOM   2592 C CA    . ALA A 1 335 ? 32.796  23.825  19.466 1.00 130.11 ? 337  ALA A CA    1 ? 
ATOM   2593 C C     . ALA A 1 335 ? 34.032  22.925  19.365 1.00 136.13 ? 337  ALA A C     1 ? 
ATOM   2594 O O     . ALA A 1 335 ? 33.966  21.914  18.636 1.00 140.66 ? 337  ALA A O     1 ? 
ATOM   2595 C CB    . ALA A 1 335 ? 32.514  24.123  20.918 1.00 130.21 ? 337  ALA A CB    1 ? 
ATOM   2596 N N     . LEU A 1 336 ? 35.114  23.289  20.060 0.50 141.54 ? 338  LEU A N     1 ? 
ATOM   2597 C CA    . LEU A 1 336 ? 36.357  22.468  20.059 0.50 144.13 ? 338  LEU A CA    1 ? 
ATOM   2598 C C     . LEU A 1 336 ? 36.890  22.435  18.622 0.50 147.80 ? 338  LEU A C     1 ? 
ATOM   2599 O O     . LEU A 1 336 ? 37.082  21.324  18.091 0.50 149.36 ? 338  LEU A O     1 ? 
ATOM   2600 C CB    . LEU A 1 336 ? 36.084  21.053  20.578 0.50 144.19 ? 338  LEU A CB    1 ? 
ATOM   2601 C CG    . LEU A 1 336 ? 35.529  20.970  21.999 0.50 143.80 ? 338  LEU A CG    1 ? 
ATOM   2602 C CD1   . LEU A 1 336 ? 35.311  19.522  22.408 0.50 141.48 ? 338  LEU A CD1   1 ? 
ATOM   2603 C CD2   . LEU A 1 336 ? 36.456  21.667  22.983 0.50 140.41 ? 338  LEU A CD2   1 ? 
ATOM   2604 N N     . ASN A 1 337 ? 37.118  23.607  18.022 0.50 149.90 ? 339  ASN A N     1 ? 
ATOM   2605 C CA    . ASN A 1 337 ? 37.679  23.669  16.645 0.50 148.18 ? 339  ASN A CA    1 ? 
ATOM   2606 C C     . ASN A 1 337 ? 39.060  23.006  16.645 0.50 150.32 ? 339  ASN A C     1 ? 
ATOM   2607 O O     . ASN A 1 337 ? 39.296  22.146  15.775 0.50 152.72 ? 339  ASN A O     1 ? 
ATOM   2608 C CB    . ASN A 1 337 ? 37.729  25.106  16.121 0.50 143.09 ? 339  ASN A CB    1 ? 
ATOM   2609 C CG    . ASN A 1 337 ? 36.375  25.781  16.135 0.50 135.13 ? 339  ASN A CG    1 ? 
ATOM   2610 O OD1   . ASN A 1 337 ? 35.384  25.188  16.556 0.50 124.69 ? 339  ASN A OD1   1 ? 
ATOM   2611 N ND2   . ASN A 1 337 ? 36.321  27.021  15.677 0.50 128.05 ? 339  ASN A ND2   1 ? 
ATOM   2612 N N     . LYS A 1 338 ? 39.929  23.384  17.588 0.50 147.79 ? 340  LYS A N     1 ? 
ATOM   2613 C CA    . LYS A 1 338 ? 41.260  22.729  17.707 0.50 148.37 ? 340  LYS A CA    1 ? 
ATOM   2614 C C     . LYS A 1 338 ? 41.183  21.682  18.822 0.50 147.59 ? 340  LYS A C     1 ? 
ATOM   2615 O O     . LYS A 1 338 ? 41.809  21.898  19.878 0.50 144.22 ? 340  LYS A O     1 ? 
ATOM   2616 C CB    . LYS A 1 338 ? 42.358  23.761  17.978 0.50 145.31 ? 340  LYS A CB    1 ? 
ATOM   2617 C CG    . LYS A 1 338 ? 42.881  24.488  16.747 0.50 141.16 ? 340  LYS A CG    1 ? 
ATOM   2618 C CD    . LYS A 1 338 ? 44.168  25.241  17.001 0.50 137.14 ? 340  LYS A CD    1 ? 
ATOM   2619 C CE    . LYS A 1 338 ? 44.789  25.797  15.737 0.50 132.12 ? 340  LYS A CE    1 ? 
ATOM   2620 N NZ    . LYS A 1 338 ? 46.039  26.541  16.022 0.50 121.94 ? 340  LYS A NZ    1 ? 
ATOM   2621 N N     . ASP A 1 339 ? 40.440  20.598  18.589 0.50 149.77 ? 341  ASP A N     1 ? 
ATOM   2622 C CA    . ASP A 1 339 ? 40.254  19.549  19.628 0.50 148.70 ? 341  ASP A CA    1 ? 
ATOM   2623 C C     . ASP A 1 339 ? 41.234  18.404  19.377 0.50 149.04 ? 341  ASP A C     1 ? 
ATOM   2624 O O     . ASP A 1 339 ? 41.356  17.530  20.250 0.50 144.08 ? 341  ASP A O     1 ? 
ATOM   2625 C CB    . ASP A 1 339 ? 38.818  19.028  19.648 0.50 146.00 ? 341  ASP A CB    1 ? 
ATOM   2626 C CG    . ASP A 1 339 ? 38.466  18.208  18.420 0.50 145.95 ? 341  ASP A CG    1 ? 
ATOM   2627 O OD1   . ASP A 1 339 ? 39.053  18.472  17.351 0.50 144.83 ? 341  ASP A OD1   1 ? 
ATOM   2628 O OD2   . ASP A 1 339 ? 37.618  17.304  18.545 0.50 144.47 ? 341  ASP A OD2   1 ? 
ATOM   2629 N N     . GLY A 1 340 ? 41.896  18.417  18.221 0.50 144.76 ? 342  GLY A N     1 ? 
ATOM   2630 C CA    . GLY A 1 340 ? 42.867  17.360  17.887 0.50 142.18 ? 342  GLY A CA    1 ? 
ATOM   2631 C C     . GLY A 1 340 ? 42.313  16.426  16.833 0.50 144.06 ? 342  GLY A C     1 ? 
ATOM   2632 O O     . GLY A 1 340 ? 41.354  15.701  17.144 0.50 147.50 ? 342  GLY A O     1 ? 
ATOM   2633 N N     . GLY A 1 341 ? 42.887  16.445  15.626 0.50 143.24 ? 343  GLY A N     1 ? 
ATOM   2634 C CA    . GLY A 1 341 ? 42.433  15.546  14.548 0.50 143.97 ? 343  GLY A CA    1 ? 
ATOM   2635 C C     . GLY A 1 341 ? 42.554  16.189  13.178 0.50 146.55 ? 343  GLY A C     1 ? 
ATOM   2636 O O     . GLY A 1 341 ? 42.919  17.380  13.117 0.50 141.68 ? 343  GLY A O     1 ? 
ATOM   2637 N N     . ASP A 1 342 ? 42.258  15.432  12.118 0.50 155.55 ? 344  ASP A N     1 ? 
ATOM   2638 C CA    . ASP A 1 342 ? 42.381  15.957  10.732 0.50 157.82 ? 344  ASP A CA    1 ? 
ATOM   2639 C C     . ASP A 1 342 ? 40.990  16.273  10.175 0.50 158.33 ? 344  ASP A C     1 ? 
ATOM   2640 O O     . ASP A 1 342 ? 40.811  17.385  9.642  0.50 157.13 ? 344  ASP A O     1 ? 
ATOM   2641 C CB    . ASP A 1 342 ? 43.121  14.966  9.830  0.50 156.27 ? 344  ASP A CB    1 ? 
ATOM   2642 C CG    . ASP A 1 342 ? 43.273  15.445  8.396  0.50 155.49 ? 344  ASP A CG    1 ? 
ATOM   2643 O OD1   . ASP A 1 342 ? 43.407  16.669  8.197  0.50 156.73 ? 344  ASP A OD1   1 ? 
ATOM   2644 O OD2   . ASP A 1 342 ? 43.248  14.589  7.489  0.50 153.04 ? 344  ASP A OD2   1 ? 
ATOM   2645 N N     . GLU A 1 343 ? 40.045  15.335  10.297 0.50 159.62 ? 345  GLU A N     1 ? 
ATOM   2646 C CA    . GLU A 1 343 ? 38.697  15.535  9.700  0.50 158.18 ? 345  GLU A CA    1 ? 
ATOM   2647 C C     . GLU A 1 343 ? 37.614  15.351  10.769 0.50 159.63 ? 345  GLU A C     1 ? 
ATOM   2648 O O     . GLU A 1 343 ? 37.967  15.003  11.913 0.50 159.06 ? 345  GLU A O     1 ? 
ATOM   2649 C CB    . GLU A 1 343 ? 38.483  14.558  8.543  0.50 156.26 ? 345  GLU A CB    1 ? 
ATOM   2650 C CG    . GLU A 1 343 ? 39.534  14.675  7.455  0.50 156.69 ? 345  GLU A CG    1 ? 
ATOM   2651 C CD    . GLU A 1 343 ? 39.398  13.664  6.330  0.50 153.94 ? 345  GLU A CD    1 ? 
ATOM   2652 O OE1   . GLU A 1 343 ? 38.439  12.868  6.366  0.50 151.29 ? 345  GLU A OE1   1 ? 
ATOM   2653 O OE2   . GLU A 1 343 ? 40.253  13.673  5.423  0.50 139.62 ? 345  GLU A OE2   1 ? 
ATOM   2654 N N     . VAL A 1 344 ? 36.349  15.578  10.401 0.50 156.95 ? 346  VAL A N     1 ? 
ATOM   2655 C CA    . VAL A 1 344 ? 35.211  15.433  11.359 0.50 155.71 ? 346  VAL A CA    1 ? 
ATOM   2656 C C     . VAL A 1 344 ? 35.163  13.987  11.868 0.50 159.29 ? 346  VAL A C     1 ? 
ATOM   2657 O O     . VAL A 1 344 ? 35.578  13.083  11.116 0.50 158.29 ? 346  VAL A O     1 ? 
ATOM   2658 C CB    . VAL A 1 344 ? 33.886  15.867  10.701 0.50 152.45 ? 346  VAL A CB    1 ? 
ATOM   2659 C CG1   . VAL A 1 344 ? 33.753  15.339  9.281  0.50 151.96 ? 346  VAL A CG1   1 ? 
ATOM   2660 C CG2   . VAL A 1 344 ? 32.666  15.508  11.536 0.50 152.31 ? 346  VAL A CG2   1 ? 
ATOM   2661 N N     . SER A 1 345 ? 34.685  13.781  13.099 0.50 162.50 ? 347  SER A N     1 ? 
ATOM   2662 C CA    . SER A 1 345 ? 34.636  12.422  13.702 0.50 161.18 ? 347  SER A CA    1 ? 
ATOM   2663 C C     . SER A 1 345 ? 33.508  11.585  13.093 0.50 160.00 ? 347  SER A C     1 ? 
ATOM   2664 O O     . SER A 1 345 ? 32.419  11.558  13.688 0.50 157.71 ? 347  SER A O     1 ? 
ATOM   2665 C CB    . SER A 1 345 ? 34.480  12.520  15.190 0.50 159.81 ? 347  SER A CB    1 ? 
ATOM   2666 O OG    . SER A 1 345 ? 35.442  13.410  15.736 0.50 159.99 ? 347  SER A OG    1 ? 
ATOM   2667 N N     . ASP A 1 346 ? 33.770  10.919  11.966 0.50 160.29 ? 348  ASP A N     1 ? 
ATOM   2668 C CA    . ASP A 1 346 ? 32.759  10.027  11.339 0.50 158.37 ? 348  ASP A CA    1 ? 
ATOM   2669 C C     . ASP A 1 346 ? 33.458  9.087   10.349 0.50 158.44 ? 348  ASP A C     1 ? 
ATOM   2670 O O     . ASP A 1 346 ? 33.115  9.134   9.154  0.50 156.14 ? 348  ASP A O     1 ? 
ATOM   2671 C CB    . ASP A 1 346 ? 31.641  10.850  10.694 0.50 150.00 ? 348  ASP A CB    1 ? 
ATOM   2672 C CG    . ASP A 1 346 ? 32.136  12.075  9.949  0.50 157.48 ? 348  ASP A CG    1 ? 
ATOM   2673 O OD1   . ASP A 1 346 ? 33.342  12.132  9.652  0.50 158.73 ? 348  ASP A OD1   1 ? 
ATOM   2674 O OD2   . ASP A 1 346 ? 31.309  12.964  9.682  0.50 146.09 ? 348  ASP A OD2   1 ? 
ATOM   2675 N N     . PRO A 1 347 ? 34.399  8.219   10.779 0.50 152.65 ? 349  PRO A N     1 ? 
ATOM   2676 C CA    . PRO A 1 347 ? 35.157  7.382   9.847  0.50 150.76 ? 349  PRO A CA    1 ? 
ATOM   2677 C C     . PRO A 1 347 ? 34.496  6.033   9.543  0.50 150.64 ? 349  PRO A C     1 ? 
ATOM   2678 O O     . PRO A 1 347 ? 35.014  5.315   8.712  0.50 150.00 ? 349  PRO A O     1 ? 
ATOM   2679 C CB    . PRO A 1 347 ? 36.424  7.114   10.658 0.50 150.41 ? 349  PRO A CB    1 ? 
ATOM   2680 C CG    . PRO A 1 347 ? 35.921  6.993   12.077 0.50 149.78 ? 349  PRO A CG    1 ? 
ATOM   2681 C CD    . PRO A 1 347 ? 34.780  7.985   12.174 0.50 150.06 ? 349  PRO A CD    1 ? 
ATOM   2682 N N     . THR A 1 348 ? 33.385  5.725   10.213 1.00 141.76 ? 350  THR A N     1 ? 
ATOM   2683 C CA    . THR A 1 348 ? 32.710  4.410   10.038 1.00 141.48 ? 350  THR A CA    1 ? 
ATOM   2684 C C     . THR A 1 348 ? 31.235  4.615   9.678  1.00 128.66 ? 350  THR A C     1 ? 
ATOM   2685 O O     . THR A 1 348 ? 30.571  3.618   9.315  1.00 117.59 ? 350  THR A O     1 ? 
ATOM   2686 C CB    . THR A 1 348 ? 32.821  3.575   11.319 1.00 131.22 ? 350  THR A CB    1 ? 
ATOM   2687 O OG1   . THR A 1 348 ? 31.938  2.459   11.210 1.00 118.62 ? 350  THR A OG1   1 ? 
ATOM   2688 C CG2   . THR A 1 348 ? 32.481  4.368   12.562 1.00 128.44 ? 350  THR A CG2   1 ? 
ATOM   2689 N N     . GLY A 1 349 ? 30.746  5.854   9.773  1.00 113.54 ? 351  GLY A N     1 ? 
ATOM   2690 C CA    . GLY A 1 349 ? 29.331  6.154   9.484  1.00 113.30 ? 351  GLY A CA    1 ? 
ATOM   2691 C C     . GLY A 1 349 ? 28.566  6.335   10.773 1.00 112.02 ? 351  GLY A C     1 ? 
ATOM   2692 O O     . GLY A 1 349 ? 27.454  6.880   10.736 1.00 105.91 ? 351  GLY A O     1 ? 
ATOM   2693 N N     . PHE A 1 350 ? 29.169  5.904   11.878 1.00 110.11 ? 352  PHE A N     1 ? 
ATOM   2694 C CA    . PHE A 1 350 ? 28.496  5.999   13.194 1.00 111.67 ? 352  PHE A CA    1 ? 
ATOM   2695 C C     . PHE A 1 350 ? 29.272  6.947   14.103 1.00 109.53 ? 352  PHE A C     1 ? 
ATOM   2696 O O     . PHE A 1 350 ? 30.464  7.178   13.863 1.00 120.37 ? 352  PHE A O     1 ? 
ATOM   2697 C CB    . PHE A 1 350 ? 28.374  4.619   13.849 1.00 105.63 ? 352  PHE A CB    1 ? 
ATOM   2698 C CG    . PHE A 1 350 ? 27.478  3.648   13.125 1.00 101.77 ? 352  PHE A CG    1 ? 
ATOM   2699 C CD1   . PHE A 1 350 ? 26.173  3.986   12.814 1.00 94.67  ? 352  PHE A CD1   1 ? 
ATOM   2700 C CD2   . PHE A 1 350 ? 27.938  2.393   12.767 1.00 94.03  ? 352  PHE A CD2   1 ? 
ATOM   2701 C CE1   . PHE A 1 350 ? 25.350  3.092   12.151 1.00 93.83  ? 352  PHE A CE1   1 ? 
ATOM   2702 C CE2   . PHE A 1 350 ? 27.113  1.498   12.106 1.00 99.26  ? 352  PHE A CE2   1 ? 
ATOM   2703 C CZ    . PHE A 1 350 ? 25.821  1.850   11.798 1.00 101.75 ? 352  PHE A CZ    1 ? 
ATOM   2704 N N     . SER A 1 351 ? 28.600  7.466   15.126 1.00 102.66 ? 353  SER A N     1 ? 
ATOM   2705 C CA    . SER A 1 351 ? 29.285  8.335   16.104 1.00 97.98  ? 353  SER A CA    1 ? 
ATOM   2706 C C     . SER A 1 351 ? 30.438  7.549   16.720 1.00 96.04  ? 353  SER A C     1 ? 
ATOM   2707 O O     . SER A 1 351 ? 30.348  6.318   16.793 1.00 104.01 ? 353  SER A O     1 ? 
ATOM   2708 C CB    . SER A 1 351 ? 28.314  8.801   17.140 1.00 93.91  ? 353  SER A CB    1 ? 
ATOM   2709 O OG    . SER A 1 351 ? 27.142  9.322   16.534 1.00 93.89  ? 353  SER A OG    1 ? 
ATOM   2710 N N     . PRO A 1 352 ? 31.530  8.213   17.138 1.00 102.17 ? 354  PRO A N     1 ? 
ATOM   2711 C CA    . PRO A 1 352 ? 32.673  7.522   17.701 1.00 101.84 ? 354  PRO A CA    1 ? 
ATOM   2712 C C     . PRO A 1 352 ? 32.216  6.720   18.912 1.00 100.28 ? 354  PRO A C     1 ? 
ATOM   2713 O O     . PRO A 1 352 ? 32.533  5.571   18.995 1.00 106.59 ? 354  PRO A O     1 ? 
ATOM   2714 C CB    . PRO A 1 352 ? 33.580  8.646   18.204 1.00 105.76 ? 354  PRO A CB    1 ? 
ATOM   2715 C CG    . PRO A 1 352 ? 32.744  9.906   18.141 1.00 109.24 ? 354  PRO A CG    1 ? 
ATOM   2716 C CD    . PRO A 1 352 ? 31.726  9.657   17.053 1.00 101.70 ? 354  PRO A CD    1 ? 
ATOM   2717 N N     . PHE A 1 353 ? 31.428  7.347   19.771 1.00 88.32  ? 355  PHE A N     1 ? 
ATOM   2718 C CA    . PHE A 1 353 ? 30.980  6.681   21.014 1.00 92.32  ? 355  PHE A CA    1 ? 
ATOM   2719 C C     . PHE A 1 353 ? 29.634  5.988   20.777 1.00 83.64  ? 355  PHE A C     1 ? 
ATOM   2720 O O     . PHE A 1 353 ? 28.871  6.446   19.913 1.00 75.09  ? 355  PHE A O     1 ? 
ATOM   2721 C CB    . PHE A 1 353 ? 30.910  7.733   22.118 1.00 91.96  ? 355  PHE A CB    1 ? 
ATOM   2722 C CG    . PHE A 1 353 ? 32.039  8.729   22.080 1.00 102.11 ? 355  PHE A CG    1 ? 
ATOM   2723 C CD1   . PHE A 1 353 ? 33.316  8.367   22.471 1.00 105.79 ? 355  PHE A CD1   1 ? 
ATOM   2724 C CD2   . PHE A 1 353 ? 31.825  10.025  21.642 1.00 103.90 ? 355  PHE A CD2   1 ? 
ATOM   2725 C CE1   . PHE A 1 353 ? 34.356  9.281   22.428 1.00 99.15  ? 355  PHE A CE1   1 ? 
ATOM   2726 C CE2   . PHE A 1 353 ? 32.866  10.938  21.599 1.00 105.22 ? 355  PHE A CE2   1 ? 
ATOM   2727 C CZ    . PHE A 1 353 ? 34.128  10.565  21.993 1.00 103.04 ? 355  PHE A CZ    1 ? 
ATOM   2728 N N     . PRO A 1 354 ? 29.316  4.888   21.497 1.00 82.53  ? 356  PRO A N     1 ? 
ATOM   2729 C CA    . PRO A 1 354 ? 28.058  4.180   21.273 1.00 76.93  ? 356  PRO A CA    1 ? 
ATOM   2730 C C     . PRO A 1 354 ? 26.873  5.015   21.782 1.00 72.46  ? 356  PRO A C     1 ? 
ATOM   2731 O O     . PRO A 1 354 ? 27.030  5.875   22.650 1.00 69.77  ? 356  PRO A O     1 ? 
ATOM   2732 C CB    . PRO A 1 354 ? 28.217  2.862   22.058 1.00 78.05  ? 356  PRO A CB    1 ? 
ATOM   2733 C CG    . PRO A 1 354 ? 29.687  2.823   22.507 1.00 77.43  ? 356  PRO A CG    1 ? 
ATOM   2734 C CD    . PRO A 1 354 ? 30.131  4.267   22.564 1.00 74.84  ? 356  PRO A CD    1 ? 
ATOM   2735 N N     . GLY A 1 355 ? 25.708  4.742   21.220 1.00 67.33  ? 357  GLY A N     1 ? 
ATOM   2736 C CA    . GLY A 1 355 ? 24.461  5.407   21.624 1.00 70.34  ? 357  GLY A CA    1 ? 
ATOM   2737 C C     . GLY A 1 355 ? 23.779  4.628   22.735 1.00 67.85  ? 357  GLY A C     1 ? 
ATOM   2738 O O     . GLY A 1 355 ? 23.603  3.401   22.592 1.00 73.70  ? 357  GLY A O     1 ? 
ATOM   2739 N N     . SER A 1 356 ? 23.427  5.314   23.818 1.00 62.86  ? 358  SER A N     1 ? 
ATOM   2740 C CA    . SER A 1 356 ? 22.769  4.705   24.998 1.00 56.73  ? 358  SER A CA    1 ? 
ATOM   2741 C C     . SER A 1 356 ? 21.271  4.576   24.722 1.00 60.44  ? 358  SER A C     1 ? 
ATOM   2742 O O     . SER A 1 356 ? 20.613  5.572   24.347 1.00 57.63  ? 358  SER A O     1 ? 
ATOM   2743 C CB    . SER A 1 356 ? 22.998  5.513   26.234 1.00 67.58  ? 358  SER A CB    1 ? 
ATOM   2744 O OG    . SER A 1 356 ? 22.256  4.971   27.306 1.00 68.28  ? 358  SER A OG    1 ? 
ATOM   2745 N N     . VAL A 1 357 ? 20.746  3.385   24.941 1.00 59.78  ? 359  VAL A N     1 ? 
ATOM   2746 C CA    . VAL A 1 357 ? 19.323  3.056   24.692 1.00 55.41  ? 359  VAL A CA    1 ? 
ATOM   2747 C C     . VAL A 1 357 ? 18.535  3.295   25.984 1.00 56.85  ? 359  VAL A C     1 ? 
ATOM   2748 O O     . VAL A 1 357 ? 17.323  3.400   25.903 1.00 56.44  ? 359  VAL A O     1 ? 
ATOM   2749 C CB    . VAL A 1 357 ? 19.260  1.602   24.184 1.00 66.78  ? 359  VAL A CB    1 ? 
ATOM   2750 C CG1   . VAL A 1 357 ? 17.979  0.894   24.549 1.00 73.25  ? 359  VAL A CG1   1 ? 
ATOM   2751 C CG2   . VAL A 1 357 ? 19.513  1.570   22.687 1.00 64.40  ? 359  VAL A CG2   1 ? 
ATOM   2752 N N     . ASN A 1 358 ? 19.201  3.426   27.133 1.00 58.22  ? 360  ASN A N     1 ? 
ATOM   2753 C CA    . ASN A 1 358 ? 18.550  3.660   28.459 1.00 53.77  ? 360  ASN A CA    1 ? 
ATOM   2754 C C     . ASN A 1 358 ? 17.790  2.403   28.916 1.00 59.10  ? 360  ASN A C     1 ? 
ATOM   2755 O O     . ASN A 1 358 ? 16.717  2.509   29.569 1.00 62.80  ? 360  ASN A O     1 ? 
ATOM   2756 C CB    . ASN A 1 358 ? 17.628  4.876   28.437 1.00 58.10  ? 360  ASN A CB    1 ? 
ATOM   2757 C CG    . ASN A 1 358 ? 17.903  5.844   29.573 1.00 54.81  ? 360  ASN A CG    1 ? 
ATOM   2758 O OD1   . ASN A 1 358 ? 18.974  5.837   30.159 1.00 54.56  ? 360  ASN A OD1   1 ? 
ATOM   2759 N ND2   . ASN A 1 358 ? 16.950  6.693   29.878 1.00 56.07  ? 360  ASN A ND2   1 ? 
ATOM   2760 N N     . THR A 1 359 ? 18.366  1.238   28.639 1.00 56.99  ? 361  THR A N     1 ? 
ATOM   2761 C CA    . THR A 1 359 ? 18.101  0.012   29.403 1.00 58.99  ? 361  THR A CA    1 ? 
ATOM   2762 C C     . THR A 1 359 ? 19.314  -0.180  30.310 1.00 54.97  ? 361  THR A C     1 ? 
ATOM   2763 O O     . THR A 1 359 ? 20.374  -0.549  29.790 1.00 57.12  ? 361  THR A O     1 ? 
ATOM   2764 C CB    . THR A 1 359 ? 17.834  -1.180  28.483 1.00 56.24  ? 361  THR A CB    1 ? 
ATOM   2765 O OG1   . THR A 1 359 ? 16.688  -0.954  27.672 1.00 57.01  ? 361  THR A OG1   1 ? 
ATOM   2766 C CG2   . THR A 1 359 ? 17.590  -2.432  29.277 1.00 53.68  ? 361  THR A CG2   1 ? 
ATOM   2767 N N     . LEU A 1 360 ? 19.151  0.098   31.599 1.00 52.94  ? 362  LEU A N     1 ? 
ATOM   2768 C CA    . LEU A 1 360 ? 20.288  0.136   32.555 1.00 60.81  ? 362  LEU A CA    1 ? 
ATOM   2769 C C     . LEU A 1 360 ? 20.318  -1.134  33.397 1.00 61.26  ? 362  LEU A C     1 ? 
ATOM   2770 O O     . LEU A 1 360 ? 19.265  -1.489  33.977 1.00 67.50  ? 362  LEU A O     1 ? 
ATOM   2771 C CB    . LEU A 1 360 ? 20.146  1.371   33.451 1.00 54.32  ? 362  LEU A CB    1 ? 
ATOM   2772 C CG    . LEU A 1 360 ? 19.791  2.647   32.701 1.00 51.79  ? 362  LEU A CG    1 ? 
ATOM   2773 C CD1   . LEU A 1 360 ? 19.627  3.790   33.663 1.00 59.37  ? 362  LEU A CD1   1 ? 
ATOM   2774 C CD2   . LEU A 1 360 ? 20.845  2.967   31.661 1.00 53.24  ? 362  LEU A CD2   1 ? 
ATOM   2775 N N     . VAL A 1 361 ? 21.494  -1.749  33.489 1.00 61.40  ? 363  VAL A N     1 ? 
ATOM   2776 C CA    . VAL A 1 361 ? 21.691  -3.003  34.275 1.00 58.03  ? 363  VAL A CA    1 ? 
ATOM   2777 C C     . VAL A 1 361 ? 22.668  -2.739  35.413 1.00 62.77  ? 363  VAL A C     1 ? 
ATOM   2778 O O     . VAL A 1 361 ? 23.854  -2.508  35.138 1.00 69.54  ? 363  VAL A O     1 ? 
ATOM   2779 C CB    . VAL A 1 361 ? 22.195  -4.136  33.379 1.00 56.47  ? 363  VAL A CB    1 ? 
ATOM   2780 C CG1   . VAL A 1 361 ? 22.397  -5.407  34.175 1.00 60.71  ? 363  VAL A CG1   1 ? 
ATOM   2781 C CG2   . VAL A 1 361 ? 21.232  -4.356  32.226 1.00 56.93  ? 363  VAL A CG2   1 ? 
ATOM   2782 N N     . PHE A 1 362 ? 22.170  -2.770  36.646 1.00 69.34  ? 364  PHE A N     1 ? 
ATOM   2783 C CA    . PHE A 1 362 ? 22.987  -2.529  37.858 1.00 64.86  ? 364  PHE A CA    1 ? 
ATOM   2784 C C     . PHE A 1 362 ? 23.170  -3.848  38.593 1.00 69.64  ? 364  PHE A C     1 ? 
ATOM   2785 O O     . PHE A 1 362 ? 22.249  -4.699  38.621 1.00 67.90  ? 364  PHE A O     1 ? 
ATOM   2786 C CB    . PHE A 1 362 ? 22.324  -1.516  38.782 1.00 64.05  ? 364  PHE A CB    1 ? 
ATOM   2787 C CG    . PHE A 1 362 ? 22.134  -0.155  38.180 1.00 63.93  ? 364  PHE A CG    1 ? 
ATOM   2788 C CD1   . PHE A 1 362 ? 21.044  0.124   37.377 1.00 63.48  ? 364  PHE A CD1   1 ? 
ATOM   2789 C CD2   . PHE A 1 362 ? 23.047  0.854   38.435 1.00 70.17  ? 364  PHE A CD2   1 ? 
ATOM   2790 C CE1   . PHE A 1 362 ? 20.870  1.394   36.850 1.00 67.82  ? 364  PHE A CE1   1 ? 
ATOM   2791 C CE2   . PHE A 1 362 ? 22.865  2.126   37.910 1.00 68.44  ? 364  PHE A CE2   1 ? 
ATOM   2792 C CZ    . PHE A 1 362 ? 21.782  2.388   37.112 1.00 63.63  ? 364  PHE A CZ    1 ? 
ATOM   2793 N N     . LYS A 1 363 ? 24.352  -4.003  39.168 1.00 72.80  ? 365  LYS A N     1 ? 
ATOM   2794 C CA    . LYS A 1 363 ? 24.549  -4.903  40.319 1.00 71.48  ? 365  LYS A CA    1 ? 
ATOM   2795 C C     . LYS A 1 363 ? 23.777  -4.308  41.491 1.00 67.17  ? 365  LYS A C     1 ? 
ATOM   2796 O O     . LYS A 1 363 ? 23.929  -3.097  41.755 1.00 74.44  ? 365  LYS A O     1 ? 
ATOM   2797 C CB    . LYS A 1 363 ? 26.036  -5.040  40.616 1.00 77.19  ? 365  LYS A CB    1 ? 
ATOM   2798 C CG    . LYS A 1 363 ? 26.372  -6.070  41.672 1.00 80.86  ? 365  LYS A CG    1 ? 
ATOM   2799 C CD    . LYS A 1 363 ? 27.873  -6.135  41.975 1.00 74.89  ? 365  LYS A CD    1 ? 
ATOM   2800 C CE    . LYS A 1 363 ? 28.214  -7.323  42.854 1.00 73.36  ? 365  LYS A CE    1 ? 
ATOM   2801 N NZ    . LYS A 1 363 ? 28.897  -6.896  44.097 1.00 78.99  ? 365  LYS A NZ    1 ? 
ATOM   2802 N N     . LEU A 1 364 ? 22.935  -5.114  42.134 1.00 57.79  ? 366  LEU A N     1 ? 
ATOM   2803 C CA    . LEU A 1 364 ? 21.998  -4.583  43.151 1.00 63.72  ? 366  LEU A CA    1 ? 
ATOM   2804 C C     . LEU A 1 364 ? 22.769  -4.011  44.346 1.00 68.97  ? 366  LEU A C     1 ? 
ATOM   2805 O O     . LEU A 1 364 ? 22.359  -2.974  44.872 1.00 71.52  ? 366  LEU A O     1 ? 
ATOM   2806 C CB    . LEU A 1 364 ? 21.051  -5.690  43.613 1.00 65.71  ? 366  LEU A CB    1 ? 
ATOM   2807 C CG    . LEU A 1 364 ? 19.922  -5.201  44.518 1.00 61.52  ? 366  LEU A CG    1 ? 
ATOM   2808 C CD1   . LEU A 1 364 ? 19.220  -4.002  43.906 1.00 63.38  ? 366  LEU A CD1   1 ? 
ATOM   2809 C CD2   . LEU A 1 364 ? 18.935  -6.313  44.793 1.00 62.73  ? 366  LEU A CD2   1 ? 
ATOM   2810 N N     . SER A 1 365 ? 23.836  -4.669  44.785 1.00 73.50  ? 367  SER A N     1 ? 
ATOM   2811 C CA    . SER A 1 365 ? 24.586  -4.219  45.988 1.00 73.52  ? 367  SER A CA    1 ? 
ATOM   2812 C C     . SER A 1 365 ? 25.165  -2.819  45.758 1.00 68.13  ? 367  SER A C     1 ? 
ATOM   2813 O O     . SER A 1 365 ? 24.920  -1.938  46.585 1.00 70.96  ? 367  SER A O     1 ? 
ATOM   2814 C CB    . SER A 1 365 ? 25.661  -5.205  46.357 1.00 69.20  ? 367  SER A CB    1 ? 
ATOM   2815 O OG    . SER A 1 365 ? 26.558  -5.394  45.268 1.00 72.68  ? 367  SER A OG    1 ? 
ATOM   2816 N N     . SER A 1 366 ? 25.865  -2.618  44.643 1.00 68.65  ? 368  SER A N     1 ? 
ATOM   2817 C CA    . SER A 1 366 ? 26.472  -1.309  44.299 1.00 67.72  ? 368  SER A CA    1 ? 
ATOM   2818 C C     . SER A 1 366 ? 25.389  -0.250  44.138 1.00 68.16  ? 368  SER A C     1 ? 
ATOM   2819 O O     . SER A 1 366 ? 25.586  0.881   44.603 1.00 74.85  ? 368  SER A O     1 ? 
ATOM   2820 C CB    . SER A 1 366 ? 27.315  -1.409  43.056 1.00 70.16  ? 368  SER A CB    1 ? 
ATOM   2821 O OG    . SER A 1 366 ? 28.111  -2.598  43.054 1.00 72.55  ? 368  SER A OG    1 ? 
ATOM   2822 N N     . TYR A 1 367 ? 24.281  -0.611  43.501 1.00 75.93  ? 369  TYR A N     1 ? 
ATOM   2823 C CA    . TYR A 1 367 ? 23.154  0.333   43.272 1.00 70.22  ? 369  TYR A CA    1 ? 
ATOM   2824 C C     . TYR A 1 367 ? 22.610  0.774   44.621 1.00 62.93  ? 369  TYR A C     1 ? 
ATOM   2825 O O     . TYR A 1 367 ? 22.354  1.964   44.829 1.00 72.69  ? 369  TYR A O     1 ? 
ATOM   2826 C CB    . TYR A 1 367 ? 22.063  -0.299  42.405 1.00 65.65  ? 369  TYR A CB    1 ? 
ATOM   2827 C CG    . TYR A 1 367 ? 20.864  0.586   42.221 1.00 61.70  ? 369  TYR A CG    1 ? 
ATOM   2828 C CD1   . TYR A 1 367 ? 20.851  1.572   41.246 1.00 67.81  ? 369  TYR A CD1   1 ? 
ATOM   2829 C CD2   . TYR A 1 367 ? 19.776  0.495   43.068 1.00 57.20  ? 369  TYR A CD2   1 ? 
ATOM   2830 C CE1   . TYR A 1 367 ? 19.779  2.443   41.116 1.00 66.26  ? 369  TYR A CE1   1 ? 
ATOM   2831 C CE2   . TYR A 1 367 ? 18.696  1.348   42.942 1.00 57.48  ? 369  TYR A CE2   1 ? 
ATOM   2832 C CZ    . TYR A 1 367 ? 18.700  2.324   41.968 1.00 57.48  ? 369  TYR A CZ    1 ? 
ATOM   2833 O OH    . TYR A 1 367 ? 17.622  3.138   41.866 1.00 64.81  ? 369  TYR A OH    1 ? 
ATOM   2834 N N     . VAL A 1 368 ? 22.444  -0.173  45.534 1.00 69.29  ? 370  VAL A N     1 ? 
ATOM   2835 C CA    . VAL A 1 368 ? 21.855  0.151   46.867 1.00 72.58  ? 370  VAL A CA    1 ? 
ATOM   2836 C C     . VAL A 1 368 ? 22.834  1.055   47.629 1.00 75.91  ? 370  VAL A C     1 ? 
ATOM   2837 O O     . VAL A 1 368 ? 22.368  2.033   48.283 1.00 74.70  ? 370  VAL A O     1 ? 
ATOM   2838 C CB    . VAL A 1 368 ? 21.489  -1.124  47.637 1.00 70.76  ? 370  VAL A CB    1 ? 
ATOM   2839 C CG1   . VAL A 1 368 ? 21.205  -0.822  49.092 1.00 70.76  ? 370  VAL A CG1   1 ? 
ATOM   2840 C CG2   . VAL A 1 368 ? 20.290  -1.803  46.995 1.00 71.99  ? 370  VAL A CG2   1 ? 
ATOM   2841 N N     . ASP A 1 369 ? 24.132  0.755   47.539 1.00 73.18  ? 371  ASP A N     1 ? 
ATOM   2842 C CA    . ASP A 1 369 ? 25.170  1.541   48.247 1.00 76.20  ? 371  ASP A CA    1 ? 
ATOM   2843 C C     . ASP A 1 369 ? 25.040  2.995   47.799 1.00 80.25  ? 371  ASP A C     1 ? 
ATOM   2844 O O     . ASP A 1 369 ? 24.893  3.889   48.669 1.00 75.06  ? 371  ASP A O     1 ? 
ATOM   2845 C CB    . ASP A 1 369 ? 26.565  0.961   48.000 1.00 82.07  ? 371  ASP A CB    1 ? 
ATOM   2846 C CG    . ASP A 1 369 ? 26.838  -0.336  48.768 1.00 85.22  ? 371  ASP A CG    1 ? 
ATOM   2847 O OD1   . ASP A 1 369 ? 26.097  -0.616  49.752 1.00 79.76  ? 371  ASP A OD1   1 ? 
ATOM   2848 O OD2   . ASP A 1 369 ? 27.783  -1.080  48.369 1.00 71.93  ? 371  ASP A OD2   1 ? 
ATOM   2849 N N     . ARG A 1 370 ? 25.030  3.223   46.485 1.00 79.66  ? 372  ARG A N     1 ? 
ATOM   2850 C CA    . ARG A 1 370 ? 25.033  4.614   45.955 1.00 73.26  ? 372  ARG A CA    1 ? 
ATOM   2851 C C     . ARG A 1 370 ? 23.682  5.267   46.227 1.00 75.67  ? 372  ARG A C     1 ? 
ATOM   2852 O O     . ARG A 1 370 ? 23.657  6.488   46.486 1.00 77.72  ? 372  ARG A O     1 ? 
ATOM   2853 C CB    . ARG A 1 370 ? 25.342  4.634   44.464 1.00 74.22  ? 372  ARG A CB    1 ? 
ATOM   2854 C CG    . ARG A 1 370 ? 26.639  3.929   44.104 1.00 80.92  ? 372  ARG A CG    1 ? 
ATOM   2855 C CD    . ARG A 1 370 ? 27.853  4.762   44.444 1.00 87.33  ? 372  ARG A CD    1 ? 
ATOM   2856 N NE    . ARG A 1 370 ? 28.349  4.498   45.796 1.00 92.86  ? 372  ARG A NE    1 ? 
ATOM   2857 C CZ    . ARG A 1 370 ? 28.449  5.405   46.765 1.00 89.96  ? 372  ARG A CZ    1 ? 
ATOM   2858 N NH1   . ARG A 1 370 ? 28.097  6.664   46.559 1.00 89.80  ? 372  ARG A NH1   1 ? 
ATOM   2859 N NH2   . ARG A 1 370 ? 28.884  5.044   47.957 1.00 91.87  ? 372  ARG A NH2   1 ? 
ATOM   2860 N N     . LEU A 1 371 ? 22.599  4.491   46.184 1.00 69.29  ? 373  LEU A N     1 ? 
ATOM   2861 C CA    . LEU A 1 371 ? 21.252  5.030   46.472 1.00 68.93  ? 373  LEU A CA    1 ? 
ATOM   2862 C C     . LEU A 1 371 ? 21.188  5.477   47.930 1.00 67.34  ? 373  LEU A C     1 ? 
ATOM   2863 O O     . LEU A 1 371 ? 20.627  6.554   48.179 1.00 70.48  ? 373  LEU A O     1 ? 
ATOM   2864 C CB    . LEU A 1 371 ? 20.214  3.940   46.184 1.00 71.50  ? 373  LEU A CB    1 ? 
ATOM   2865 C CG    . LEU A 1 371 ? 18.762  4.353   46.367 1.00 65.85  ? 373  LEU A CG    1 ? 
ATOM   2866 C CD1   . LEU A 1 371 ? 18.339  5.266   45.239 1.00 68.26  ? 373  LEU A CD1   1 ? 
ATOM   2867 C CD2   . LEU A 1 371 ? 17.885  3.122   46.436 1.00 70.40  ? 373  LEU A CD2   1 ? 
ATOM   2868 N N     . ARG A 1 372 ? 21.698  4.665   48.857 1.00 74.61  ? 374  ARG A N     1 ? 
ATOM   2869 C CA    . ARG A 1 372 ? 21.710  5.039   50.301 1.00 81.40  ? 374  ARG A CA    1 ? 
ATOM   2870 C C     . ARG A 1 372 ? 22.603  6.257   50.550 1.00 77.59  ? 374  ARG A C     1 ? 
ATOM   2871 O O     . ARG A 1 372 ? 22.187  7.123   51.332 1.00 76.18  ? 374  ARG A O     1 ? 
ATOM   2872 C CB    . ARG A 1 372 ? 22.175  3.869   51.160 1.00 79.52  ? 374  ARG A CB    1 ? 
ATOM   2873 C CG    . ARG A 1 372 ? 21.106  2.812   51.365 1.00 79.06  ? 374  ARG A CG    1 ? 
ATOM   2874 C CD    . ARG A 1 372 ? 21.719  1.549   51.938 1.00 73.13  ? 374  ARG A CD    1 ? 
ATOM   2875 N NE    . ARG A 1 372 ? 20.705  0.594   52.350 1.00 68.28  ? 374  ARG A NE    1 ? 
ATOM   2876 C CZ    . ARG A 1 372 ? 20.940  -0.697  52.559 1.00 75.80  ? 374  ARG A CZ    1 ? 
ATOM   2877 N NH1   . ARG A 1 372 ? 22.157  -1.198  52.393 1.00 74.71  ? 374  ARG A NH1   1 ? 
ATOM   2878 N NH2   . ARG A 1 372 ? 19.949  -1.495  52.920 1.00 77.79  ? 374  ARG A NH2   1 ? 
ATOM   2879 N N     . GLU A 1 373 ? 23.728  6.362   49.863 1.00 83.59  ? 375  GLU A N     1 ? 
ATOM   2880 C CA    . GLU A 1 373 ? 24.624  7.525   50.040 1.00 85.31  ? 375  GLU A CA    1 ? 
ATOM   2881 C C     . GLU A 1 373 ? 23.987  8.783   49.456 1.00 84.40  ? 375  GLU A C     1 ? 
ATOM   2882 O O     . GLU A 1 373 ? 24.143  9.849   50.062 1.00 86.17  ? 375  GLU A O     1 ? 
ATOM   2883 C CB    . GLU A 1 373 ? 25.942  7.246   49.326 1.00 95.71  ? 375  GLU A CB    1 ? 
ATOM   2884 C CG    . GLU A 1 373 ? 26.858  8.450   49.226 1.00 101.55 ? 375  GLU A CG    1 ? 
ATOM   2885 C CD    . GLU A 1 373 ? 27.721  8.694   50.451 1.00 110.47 ? 375  GLU A CD    1 ? 
ATOM   2886 O OE1   . GLU A 1 373 ? 27.624  7.903   51.407 1.00 112.32 ? 375  GLU A OE1   1 ? 
ATOM   2887 O OE2   . GLU A 1 373 ? 28.489  9.672   50.443 1.00 111.97 ? 375  GLU A OE2   1 ? 
ATOM   2888 N N     . SER A 1 374 ? 23.268  8.658   48.347 1.00 82.72  ? 376  SER A N     1 ? 
ATOM   2889 C CA    . SER A 1 374 ? 22.743  9.859   47.638 1.00 76.36  ? 376  SER A CA    1 ? 
ATOM   2890 C C     . SER A 1 374 ? 21.284  10.143  47.988 1.00 69.84  ? 376  SER A C     1 ? 
ATOM   2891 O O     . SER A 1 374 ? 20.800  11.201  47.579 1.00 69.37  ? 376  SER A O     1 ? 
ATOM   2892 C CB    . SER A 1 374 ? 22.904  9.724   46.153 1.00 79.77  ? 376  SER A CB    1 ? 
ATOM   2893 O OG    . SER A 1 374 ? 21.845  8.940   45.601 1.00 75.28  ? 376  SER A OG    1 ? 
ATOM   2894 N N     . HIS A 1 375 ? 20.611  9.235   48.695 1.00 78.38  ? 377  HIS A N     1 ? 
ATOM   2895 C CA    . HIS A 1 375 ? 19.157  9.332   49.016 1.00 83.17  ? 377  HIS A CA    1 ? 
ATOM   2896 C C     . HIS A 1 375 ? 18.310  9.289   47.731 1.00 76.50  ? 377  HIS A C     1 ? 
ATOM   2897 O O     . HIS A 1 375 ? 17.132  9.701   47.760 1.00 80.87  ? 377  HIS A O     1 ? 
ATOM   2898 C CB    . HIS A 1 375 ? 18.875  10.603  49.842 1.00 82.06  ? 377  HIS A CB    1 ? 
ATOM   2899 C CG    . HIS A 1 375 ? 19.271  10.494  51.276 1.00 85.01  ? 377  HIS A CG    1 ? 
ATOM   2900 N ND1   . HIS A 1 375 ? 18.552  11.097  52.291 1.00 84.01  ? 377  HIS A ND1   1 ? 
ATOM   2901 C CD2   . HIS A 1 375 ? 20.295  9.843   51.868 1.00 87.75  ? 377  HIS A CD2   1 ? 
ATOM   2902 C CE1   . HIS A 1 375 ? 19.119  10.823  53.448 1.00 89.32  ? 377  HIS A CE1   1 ? 
ATOM   2903 N NE2   . HIS A 1 375 ? 20.195  10.062  53.216 1.00 93.89  ? 377  HIS A NE2   1 ? 
ATOM   2904 N N     . GLY A 1 376 ? 18.876  8.803   46.632 1.00 76.71  ? 378  GLY A N     1 ? 
ATOM   2905 C CA    . GLY A 1 376 ? 18.179  8.779   45.331 1.00 81.27  ? 378  GLY A CA    1 ? 
ATOM   2906 C C     . GLY A 1 376 ? 18.324  10.068  44.549 1.00 77.42  ? 378  GLY A C     1 ? 
ATOM   2907 O O     . GLY A 1 376 ? 17.862  10.087  43.393 1.00 73.37  ? 378  GLY A O     1 ? 
ATOM   2908 N N     . ILE A 1 377 ? 18.968  11.087  45.124 1.00 76.63  ? 379  ILE A N     1 ? 
ATOM   2909 C CA    . ILE A 1 377 ? 19.123  12.403  44.455 1.00 71.30  ? 379  ILE A CA    1 ? 
ATOM   2910 C C     . ILE A 1 377 ? 20.163  12.256  43.354 1.00 70.47  ? 379  ILE A C     1 ? 
ATOM   2911 O O     . ILE A 1 377 ? 21.223  11.668  43.588 1.00 81.04  ? 379  ILE A O     1 ? 
ATOM   2912 C CB    . ILE A 1 377 ? 19.464  13.513  45.462 1.00 73.25  ? 379  ILE A CB    1 ? 
ATOM   2913 C CG1   . ILE A 1 377 ? 18.431  13.553  46.589 1.00 74.82  ? 379  ILE A CG1   1 ? 
ATOM   2914 C CG2   . ILE A 1 377 ? 19.560  14.859  44.764 1.00 70.60  ? 379  ILE A CG2   1 ? 
ATOM   2915 C CD1   . ILE A 1 377 ? 17.004  13.646  46.086 1.00 76.84  ? 379  ILE A CD1   1 ? 
ATOM   2916 N N     . VAL A 1 378 ? 19.840  12.774  42.180 1.00 73.02  ? 380  VAL A N     1 ? 
ATOM   2917 C CA    . VAL A 1 378 ? 20.768  12.781  41.020 1.00 70.27  ? 380  VAL A CA    1 ? 
ATOM   2918 C C     . VAL A 1 378 ? 20.920  14.215  40.545 1.00 66.59  ? 380  VAL A C     1 ? 
ATOM   2919 O O     . VAL A 1 378 ? 20.035  15.039  40.739 1.00 63.17  ? 380  VAL A O     1 ? 
ATOM   2920 C CB    . VAL A 1 378 ? 20.258  11.875  39.883 1.00 74.34  ? 380  VAL A CB    1 ? 
ATOM   2921 C CG1   . VAL A 1 378 ? 20.623  10.424  40.138 1.00 75.00  ? 380  VAL A CG1   1 ? 
ATOM   2922 C CG2   . VAL A 1 378 ? 18.761  12.030  39.661 1.00 70.20  ? 380  VAL A CG2   1 ? 
ATOM   2923 N N     . PRO A 1 379 ? 22.054  14.533  39.895 1.00 66.07  ? 381  PRO A N     1 ? 
ATOM   2924 C CA    . PRO A 1 379 ? 22.272  15.872  39.372 1.00 70.31  ? 381  PRO A CA    1 ? 
ATOM   2925 C C     . PRO A 1 379 ? 21.120  16.269  38.454 1.00 66.22  ? 381  PRO A C     1 ? 
ATOM   2926 O O     . PRO A 1 379 ? 20.641  15.433  37.721 1.00 69.67  ? 381  PRO A O     1 ? 
ATOM   2927 C CB    . PRO A 1 379 ? 23.603  15.760  38.608 1.00 72.41  ? 381  PRO A CB    1 ? 
ATOM   2928 C CG    . PRO A 1 379 ? 24.331  14.651  39.340 1.00 72.65  ? 381  PRO A CG    1 ? 
ATOM   2929 C CD    . PRO A 1 379 ? 23.237  13.665  39.721 1.00 70.30  ? 381  PRO A CD    1 ? 
ATOM   2930 N N     . GLU A 1 380 ? 20.715  17.529  38.562 1.00 71.13  ? 382  GLU A N     1 ? 
ATOM   2931 C CA    . GLU A 1 380 ? 19.555  18.070  37.826 1.00 66.15  ? 382  GLU A CA    1 ? 
ATOM   2932 C C     . GLU A 1 380 ? 20.061  18.947  36.692 1.00 64.28  ? 382  GLU A C     1 ? 
ATOM   2933 O O     . GLU A 1 380 ? 21.282  19.220  36.610 1.00 67.14  ? 382  GLU A O     1 ? 
ATOM   2934 C CB    . GLU A 1 380 ? 18.640  18.863  38.751 1.00 61.47  ? 382  GLU A CB    1 ? 
ATOM   2935 C CG    . GLU A 1 380 ? 18.005  18.041  39.842 1.00 65.62  ? 382  GLU A CG    1 ? 
ATOM   2936 C CD    . GLU A 1 380 ? 17.516  18.902  40.989 1.00 70.10  ? 382  GLU A CD    1 ? 
ATOM   2937 O OE1   . GLU A 1 380 ? 18.343  19.293  41.833 1.00 79.51  ? 382  GLU A OE1   1 ? 
ATOM   2938 O OE2   . GLU A 1 380 ? 16.322  19.212  41.012 1.00 73.60  ? 382  GLU A OE2   1 ? 
ATOM   2939 N N     . PHE A 1 381 ? 19.127  19.365  35.856 1.00 61.64  ? 383  PHE A N     1 ? 
ATOM   2940 C CA    . PHE A 1 381 ? 19.387  20.319  34.757 1.00 61.93  ? 383  PHE A CA    1 ? 
ATOM   2941 C C     . PHE A 1 381 ? 18.100  21.059  34.410 1.00 61.88  ? 383  PHE A C     1 ? 
ATOM   2942 O O     . PHE A 1 381 ? 17.024  20.788  34.958 1.00 68.57  ? 383  PHE A O     1 ? 
ATOM   2943 C CB    . PHE A 1 381 ? 19.996  19.573  33.575 1.00 63.08  ? 383  PHE A CB    1 ? 
ATOM   2944 C CG    . PHE A 1 381 ? 19.012  18.790  32.745 1.00 69.23  ? 383  PHE A CG    1 ? 
ATOM   2945 C CD1   . PHE A 1 381 ? 18.641  17.506  33.107 1.00 70.60  ? 383  PHE A CD1   1 ? 
ATOM   2946 C CD2   . PHE A 1 381 ? 18.477  19.328  31.581 1.00 68.69  ? 383  PHE A CD2   1 ? 
ATOM   2947 C CE1   . PHE A 1 381 ? 17.742  16.782  32.333 1.00 71.12  ? 383  PHE A CE1   1 ? 
ATOM   2948 C CE2   . PHE A 1 381 ? 17.570  18.607  30.813 1.00 68.72  ? 383  PHE A CE2   1 ? 
ATOM   2949 C CZ    . PHE A 1 381 ? 17.203  17.335  31.189 1.00 64.65  ? 383  PHE A CZ    1 ? 
ATOM   2950 N N     . ILE A 1 382 ? 18.228  22.018  33.518 1.00 64.29  ? 384  ILE A N     1 ? 
ATOM   2951 C CA    . ILE A 1 382 ? 17.060  22.747  32.965 1.00 63.47  ? 384  ILE A CA    1 ? 
ATOM   2952 C C     . ILE A 1 382 ? 17.342  23.052  31.495 1.00 65.08  ? 384  ILE A C     1 ? 
ATOM   2953 O O     . ILE A 1 382 ? 18.495  23.315  31.131 1.00 72.29  ? 384  ILE A O     1 ? 
ATOM   2954 C CB    . ILE A 1 382 ? 16.759  24.006  33.800 1.00 65.29  ? 384  ILE A CB    1 ? 
ATOM   2955 C CG1   . ILE A 1 382 ? 15.413  24.605  33.408 1.00 64.35  ? 384  ILE A CG1   1 ? 
ATOM   2956 C CG2   . ILE A 1 382 ? 17.881  25.029  33.675 1.00 72.11  ? 384  ILE A CG2   1 ? 
ATOM   2957 C CD1   . ILE A 1 382 ? 14.867  25.534  34.417 1.00 62.42  ? 384  ILE A CD1   1 ? 
ATOM   2958 N N     . ASN A 1 383 ? 16.307  22.989  30.674 1.00 71.66  ? 385  ASN A N     1 ? 
ATOM   2959 C CA    . ASN A 1 383 ? 16.453  23.183  29.211 1.00 73.00  ? 385  ASN A CA    1 ? 
ATOM   2960 C C     . ASN A 1 383 ? 15.238  23.940  28.711 1.00 77.47  ? 385  ASN A C     1 ? 
ATOM   2961 O O     . ASN A 1 383 ? 14.338  23.354  28.113 1.00 87.07  ? 385  ASN A O     1 ? 
ATOM   2962 C CB    . ASN A 1 383 ? 16.629  21.862  28.462 1.00 76.93  ? 385  ASN A CB    1 ? 
ATOM   2963 C CG    . ASN A 1 383 ? 16.788  22.065  26.965 1.00 89.63  ? 385  ASN A CG    1 ? 
ATOM   2964 O OD1   . ASN A 1 383 ? 17.359  23.062  26.509 1.00 84.39  ? 385  ASN A OD1   1 ? 
ATOM   2965 N ND2   . ASN A 1 383 ? 16.280  21.125  26.181 1.00 87.49  ? 385  ASN A ND2   1 ? 
ATOM   2966 N N     . PRO A 1 384 ? 15.173  25.262  28.964 1.00 72.87  ? 386  PRO A N     1 ? 
ATOM   2967 C CA    . PRO A 1 384 ? 14.003  26.038  28.597 1.00 70.64  ? 386  PRO A CA    1 ? 
ATOM   2968 C C     . PRO A 1 384 ? 13.872  26.125  27.078 1.00 76.35  ? 386  PRO A C     1 ? 
ATOM   2969 O O     . PRO A 1 384 ? 14.857  25.966  26.392 1.00 76.28  ? 386  PRO A O     1 ? 
ATOM   2970 C CB    . PRO A 1 384 ? 14.243  27.423  29.208 1.00 72.29  ? 386  PRO A CB    1 ? 
ATOM   2971 C CG    . PRO A 1 384 ? 15.393  27.246  30.161 1.00 68.31  ? 386  PRO A CG    1 ? 
ATOM   2972 C CD    . PRO A 1 384 ? 16.191  26.074  29.638 1.00 72.59  ? 386  PRO A CD    1 ? 
ATOM   2973 N N     . LYS A 1 385 ? 12.639  26.349  26.625 1.00 81.82  ? 387  LYS A N     1 ? 
ATOM   2974 C CA    . LYS A 1 385 ? 12.312  26.570  25.202 1.00 79.95  ? 387  LYS A CA    1 ? 
ATOM   2975 C C     . LYS A 1 385 ? 12.068  28.058  25.034 1.00 81.86  ? 387  LYS A C     1 ? 
ATOM   2976 O O     . LYS A 1 385 ? 11.058  28.562  25.562 1.00 92.31  ? 387  LYS A O     1 ? 
ATOM   2977 C CB    . LYS A 1 385 ? 11.109  25.731  24.760 0.60 82.36  ? 387  LYS A CB    1 ? 
ATOM   2978 C CG    . LYS A 1 385 ? 11.459  24.641  23.754 0.60 85.02  ? 387  LYS A CG    1 ? 
ATOM   2979 C CD    . LYS A 1 385 ? 12.131  23.445  24.398 0.60 83.42  ? 387  LYS A CD    1 ? 
ATOM   2980 C CE    . LYS A 1 385 ? 12.892  22.590  23.408 0.60 84.10  ? 387  LYS A CE    1 ? 
ATOM   2981 N NZ    . LYS A 1 385 ? 13.995  21.846  24.062 0.60 84.75  ? 387  LYS A NZ    1 ? 
ATOM   2982 N N     . TYR A 1 386 ? 12.977  28.739  24.354 1.00 88.57  ? 388  TYR A N     1 ? 
ATOM   2983 C CA    . TYR A 1 386 ? 12.898  30.207  24.180 1.00 92.14  ? 388  TYR A CA    1 ? 
ATOM   2984 C C     . TYR A 1 386 ? 12.056  30.531  22.952 1.00 99.23  ? 388  TYR A C     1 ? 
ATOM   2985 O O     . TYR A 1 386 ? 12.024  29.724  21.987 1.00 88.46  ? 388  TYR A O     1 ? 
ATOM   2986 C CB    . TYR A 1 386 ? 14.285  30.816  24.028 1.00 87.16  ? 388  TYR A CB    1 ? 
ATOM   2987 C CG    . TYR A 1 386 ? 15.202  30.560  25.191 1.00 87.14  ? 388  TYR A CG    1 ? 
ATOM   2988 C CD1   . TYR A 1 386 ? 16.002  29.431  25.228 1.00 87.38  ? 388  TYR A CD1   1 ? 
ATOM   2989 C CD2   . TYR A 1 386 ? 15.278  31.451  26.251 1.00 85.26  ? 388  TYR A CD2   1 ? 
ATOM   2990 C CE1   . TYR A 1 386 ? 16.862  29.191  26.285 1.00 87.49  ? 388  TYR A CE1   1 ? 
ATOM   2991 C CE2   . TYR A 1 386 ? 16.123  31.221  27.322 1.00 87.20  ? 388  TYR A CE2   1 ? 
ATOM   2992 C CZ    . TYR A 1 386 ? 16.923  30.090  27.336 1.00 93.77  ? 388  TYR A CZ    1 ? 
ATOM   2993 O OH    . TYR A 1 386 ? 17.779  29.872  28.379 1.00 89.81  ? 388  TYR A OH    1 ? 
ATOM   2994 N N     . SER A 1 387 ? 11.413  31.703  22.952 1.00 106.79 ? 389  SER A N     1 ? 
ATOM   2995 C CA    . SER A 1 387 ? 10.556  32.135  21.816 1.00 111.63 ? 389  SER A CA    1 ? 
ATOM   2996 C C     . SER A 1 387 ? 11.412  32.735  20.701 1.00 113.59 ? 389  SER A C     1 ? 
ATOM   2997 O O     . SER A 1 387 ? 11.360  32.219  19.573 1.00 109.97 ? 389  SER A O     1 ? 
ATOM   2998 C CB    . SER A 1 387 ? 9.546   33.138  22.284 1.00 105.51 ? 389  SER A CB    1 ? 
ATOM   2999 O OG    . SER A 1 387 ? 10.184  34.214  22.955 1.00 99.76  ? 389  SER A OG    1 ? 
ATOM   3000 N N     . ASP A 1 388 ? 12.160  33.796  21.016 1.00 112.36 ? 390  ASP A N     1 ? 
ATOM   3001 C CA    . ASP A 1 388 ? 12.973  34.475  19.974 1.00 120.82 ? 390  ASP A CA    1 ? 
ATOM   3002 C C     . ASP A 1 388 ? 14.344  33.811  19.879 1.00 118.96 ? 390  ASP A C     1 ? 
ATOM   3003 O O     . ASP A 1 388 ? 14.753  33.081  20.817 1.00 110.17 ? 390  ASP A O     1 ? 
ATOM   3004 C CB    . ASP A 1 388 ? 13.118  35.972  20.247 1.00 117.87 ? 390  ASP A CB    1 ? 
ATOM   3005 C CG    . ASP A 1 388 ? 11.794  36.722  20.217 1.00 120.25 ? 390  ASP A CG    1 ? 
ATOM   3006 O OD1   . ASP A 1 388 ? 11.127  36.701  19.156 1.00 120.74 ? 390  ASP A OD1   1 ? 
ATOM   3007 O OD2   . ASP A 1 388 ? 11.426  37.306  21.263 1.00 118.44 ? 390  ASP A OD2   1 ? 
ATOM   3008 N N     . GLU A 1 389 ? 15.030  34.082  18.773 1.00 125.13 ? 391  GLU A N     1 ? 
ATOM   3009 C CA    . GLU A 1 389 ? 16.289  33.388  18.423 1.00 126.32 ? 391  GLU A CA    1 ? 
ATOM   3010 C C     . GLU A 1 389 ? 17.331  33.672  19.502 1.00 124.98 ? 391  GLU A C     1 ? 
ATOM   3011 O O     . GLU A 1 389 ? 18.098  32.741  19.837 1.00 122.09 ? 391  GLU A O     1 ? 
ATOM   3012 C CB    . GLU A 1 389 ? 16.779  33.842  17.053 1.00 121.86 ? 391  GLU A CB    1 ? 
ATOM   3013 C CG    . GLU A 1 389 ? 17.928  33.005  16.528 1.00 123.93 ? 391  GLU A CG    1 ? 
ATOM   3014 C CD    . GLU A 1 389 ? 17.497  31.612  16.101 1.00 125.80 ? 391  GLU A CD    1 ? 
ATOM   3015 O OE1   . GLU A 1 389 ? 16.262  31.379  16.022 1.00 124.02 ? 391  GLU A OE1   1 ? 
ATOM   3016 O OE2   . GLU A 1 389 ? 18.392  30.768  15.829 1.00 126.01 ? 391  GLU A OE2   1 ? 
ATOM   3017 N N     . THR A 1 390 ? 17.362  34.896  20.023 1.00 113.27 ? 392  THR A N     1 ? 
ATOM   3018 C CA    . THR A 1 390 ? 18.364  35.261  21.052 1.00 120.32 ? 392  THR A CA    1 ? 
ATOM   3019 C C     . THR A 1 390 ? 17.681  35.837  22.288 1.00 125.97 ? 392  THR A C     1 ? 
ATOM   3020 O O     . THR A 1 390 ? 18.219  35.645  23.403 1.00 121.79 ? 392  THR A O     1 ? 
ATOM   3021 C CB    . THR A 1 390 ? 19.400  36.229  20.478 1.00 130.48 ? 392  THR A CB    1 ? 
ATOM   3022 O OG1   . THR A 1 390 ? 20.259  36.661  21.535 1.00 126.84 ? 392  THR A OG1   1 ? 
ATOM   3023 C CG2   . THR A 1 390 ? 18.749  37.427  19.819 1.00 130.99 ? 392  THR A CG2   1 ? 
ATOM   3024 N N     . ARG A 1 391 ? 16.538  36.496  22.112 1.00 125.89 ? 393  ARG A N     1 ? 
ATOM   3025 C CA    . ARG A 1 391 ? 15.851  37.122  23.265 1.00 129.17 ? 393  ARG A CA    1 ? 
ATOM   3026 C C     . ARG A 1 391 ? 15.559  36.053  24.319 1.00 127.13 ? 393  ARG A C     1 ? 
ATOM   3027 O O     . ARG A 1 391 ? 15.093  34.937  23.947 1.00 112.93 ? 393  ARG A O     1 ? 
ATOM   3028 C CB    . ARG A 1 391 ? 14.568  37.807  22.809 1.00 126.44 ? 393  ARG A CB    1 ? 
ATOM   3029 C CG    . ARG A 1 391 ? 14.041  38.859  23.772 1.00 126.76 ? 393  ARG A CG    1 ? 
ATOM   3030 C CD    . ARG A 1 391 ? 13.061  39.765  23.048 1.00 122.79 ? 393  ARG A CD    1 ? 
ATOM   3031 N NE    . ARG A 1 391 ? 12.705  40.949  23.815 1.00 124.75 ? 393  ARG A NE    1 ? 
ATOM   3032 C CZ    . ARG A 1 391 ? 12.048  42.003  23.326 1.00 120.62 ? 393  ARG A CZ    1 ? 
ATOM   3033 N NH1   . ARG A 1 391 ? 11.644  42.024  22.068 1.00 119.56 ? 393  ARG A NH1   1 ? 
ATOM   3034 N NH2   . ARG A 1 391 ? 11.800  43.041  24.100 1.00 115.79 ? 393  ARG A NH2   1 ? 
ATOM   3035 N N     . ARG A 1 392 ? 15.807  36.401  25.582 1.00 118.67 ? 394  ARG A N     1 ? 
ATOM   3036 C CA    . ARG A 1 392 ? 15.697  35.427  26.694 1.00 121.76 ? 394  ARG A CA    1 ? 
ATOM   3037 C C     . ARG A 1 392 ? 14.269  35.407  27.231 1.00 125.56 ? 394  ARG A C     1 ? 
ATOM   3038 O O     . ARG A 1 392 ? 14.112  35.475  28.481 1.00 129.66 ? 394  ARG A O     1 ? 
ATOM   3039 C CB    . ARG A 1 392 ? 16.688  35.753  27.809 1.00 123.25 ? 394  ARG A CB    1 ? 
ATOM   3040 C CG    . ARG A 1 392 ? 18.128  35.827  27.330 1.00 123.24 ? 394  ARG A CG    1 ? 
ATOM   3041 C CD    . ARG A 1 392 ? 19.079  35.366  28.412 1.00 124.04 ? 394  ARG A CD    1 ? 
ATOM   3042 N NE    . ARG A 1 392 ? 18.997  33.929  28.642 1.00 125.99 ? 394  ARG A NE    1 ? 
ATOM   3043 C CZ    . ARG A 1 392 ? 19.765  33.254  29.495 1.00 127.67 ? 394  ARG A CZ    1 ? 
ATOM   3044 N NH1   . ARG A 1 392 ? 20.685  33.879  30.215 1.00 128.32 ? 394  ARG A NH1   1 ? 
ATOM   3045 N NH2   . ARG A 1 392 ? 19.601  31.948  29.626 1.00 124.05 ? 394  ARG A NH2   1 ? 
ATOM   3046 N N     . SER A 1 393 ? 13.280  35.280  26.338 1.00 119.84 ? 395  SER A N     1 ? 
ATOM   3047 C CA    . SER A 1 393 ? 11.850  35.177  26.728 1.00 114.12 ? 395  SER A CA    1 ? 
ATOM   3048 C C     . SER A 1 393 ? 11.397  33.732  26.554 1.00 111.52 ? 395  SER A C     1 ? 
ATOM   3049 O O     . SER A 1 393 ? 11.672  33.149  25.476 1.00 112.03 ? 395  SER A O     1 ? 
ATOM   3050 C CB    . SER A 1 393 ? 11.000  36.115  25.923 1.00 114.33 ? 395  SER A CB    1 ? 
ATOM   3051 O OG    . SER A 1 393 ? 9.664   36.161  26.418 1.00 114.92 ? 395  SER A OG    1 ? 
ATOM   3052 N N     . PHE A 1 394 ? 10.713  33.175  27.560 1.00 101.03 ? 396  PHE A N     1 ? 
ATOM   3053 C CA    . PHE A 1 394 ? 10.279  31.755  27.519 1.00 94.48  ? 396  PHE A CA    1 ? 
ATOM   3054 C C     . PHE A 1 394 ? 8.977   31.596  26.729 1.00 87.97  ? 396  PHE A C     1 ? 
ATOM   3055 O O     . PHE A 1 394 ? 8.025   32.339  26.991 1.00 79.08  ? 396  PHE A O     1 ? 
ATOM   3056 C CB    . PHE A 1 394 ? 10.057  31.228  28.938 1.00 88.12  ? 396  PHE A CB    1 ? 
ATOM   3057 C CG    . PHE A 1 394 ? 11.286  30.987  29.775 1.00 80.80  ? 396  PHE A CG    1 ? 
ATOM   3058 C CD1   . PHE A 1 394 ? 12.557  31.182  29.262 1.00 89.77  ? 396  PHE A CD1   1 ? 
ATOM   3059 C CD2   . PHE A 1 394 ? 11.165  30.561  31.087 1.00 75.60  ? 396  PHE A CD2   1 ? 
ATOM   3060 C CE1   . PHE A 1 394 ? 13.677  30.957  30.045 1.00 82.40  ? 396  PHE A CE1   1 ? 
ATOM   3061 C CE2   . PHE A 1 394 ? 12.285  30.336  31.867 1.00 80.50  ? 396  PHE A CE2   1 ? 
ATOM   3062 C CZ    . PHE A 1 394 ? 13.539  30.533  31.344 1.00 76.38  ? 396  PHE A CZ    1 ? 
ATOM   3063 N N     . LYS A 1 395 ? 8.943   30.646  25.795 1.00 86.54  ? 397  LYS A N     1 ? 
ATOM   3064 C CA    . LYS A 1 395 ? 7.683   30.357  25.068 1.00 89.78  ? 397  LYS A CA    1 ? 
ATOM   3065 C C     . LYS A 1 395 ? 6.758   29.609  26.025 1.00 92.97  ? 397  LYS A C     1 ? 
ATOM   3066 O O     . LYS A 1 395 ? 5.574   29.963  26.101 1.00 87.15  ? 397  LYS A O     1 ? 
ATOM   3067 C CB    . LYS A 1 395 ? 7.972   29.532  23.813 1.00 94.08  ? 397  LYS A CB    1 ? 
ATOM   3068 C CG    . LYS A 1 395 ? 6.764   29.173  22.960 1.00 95.84  ? 397  LYS A CG    1 ? 
ATOM   3069 C CD    . LYS A 1 395 ? 7.153   28.672  21.587 1.00 99.21  ? 397  LYS A CD    1 ? 
ATOM   3070 C CE    . LYS A 1 395 ? 5.988   28.131  20.786 1.00 100.13 ? 397  LYS A CE    1 ? 
ATOM   3071 N NZ    . LYS A 1 395 ? 5.880   26.658  20.893 1.00 96.42  ? 397  LYS A NZ    1 ? 
ATOM   3072 N N     . LYS A 1 396 ? 7.297   28.618  26.728 1.00 95.36  ? 398  LYS A N     1 ? 
ATOM   3073 C CA    . LYS A 1 396 ? 6.499   27.843  27.707 1.00 84.67  ? 398  LYS A CA    1 ? 
ATOM   3074 C C     . LYS A 1 396 ? 7.230   27.875  29.050 1.00 78.33  ? 398  LYS A C     1 ? 
ATOM   3075 O O     . LYS A 1 396 ? 8.461   27.769  29.047 1.00 76.78  ? 398  LYS A O     1 ? 
ATOM   3076 C CB    . LYS A 1 396 ? 6.329   26.397  27.235 1.00 87.95  ? 398  LYS A CB    1 ? 
ATOM   3077 C CG    . LYS A 1 396 ? 5.884   26.203  25.794 1.00 98.55  ? 398  LYS A CG    1 ? 
ATOM   3078 C CD    . LYS A 1 396 ? 6.036   24.773  25.326 1.00 98.33  ? 398  LYS A CD    1 ? 
ATOM   3079 C CE    . LYS A 1 396 ? 6.042   24.641  23.819 1.00 104.24 ? 398  LYS A CE    1 ? 
ATOM   3080 N NZ    . LYS A 1 396 ? 6.465   23.289  23.385 1.00 108.40 ? 398  LYS A NZ    1 ? 
ATOM   3081 N N     . PRO A 1 397 ? 6.528   28.001  30.191 1.00 78.05  ? 399  PRO A N     1 ? 
ATOM   3082 C CA    . PRO A 1 397 ? 7.177   27.970  31.488 1.00 74.45  ? 399  PRO A CA    1 ? 
ATOM   3083 C C     . PRO A 1 397 ? 8.132   26.777  31.581 1.00 71.17  ? 399  PRO A C     1 ? 
ATOM   3084 O O     . PRO A 1 397 ? 7.826   25.743  31.048 1.00 78.02  ? 399  PRO A O     1 ? 
ATOM   3085 C CB    . PRO A 1 397 ? 5.989   27.835  32.435 1.00 74.35  ? 399  PRO A CB    1 ? 
ATOM   3086 C CG    . PRO A 1 397 ? 4.895   28.592  31.737 1.00 75.27  ? 399  PRO A CG    1 ? 
ATOM   3087 C CD    . PRO A 1 397 ? 5.086   28.225  30.282 1.00 81.20  ? 399  PRO A CD    1 ? 
ATOM   3088 N N     . ALA A 1 398 ? 9.249   26.951  32.276 1.00 73.51  ? 400  ALA A N     1 ? 
ATOM   3089 C CA    . ALA A 1 398 ? 10.283  25.900  32.323 1.00 66.44  ? 400  ALA A CA    1 ? 
ATOM   3090 C C     . ALA A 1 398 ? 10.296  25.191  33.672 1.00 67.41  ? 400  ALA A C     1 ? 
ATOM   3091 O O     . ALA A 1 398 ? 9.727   25.736  34.608 1.00 66.79  ? 400  ALA A O     1 ? 
ATOM   3092 C CB    . ALA A 1 398 ? 11.611  26.532  32.034 1.00 71.24  ? 400  ALA A CB    1 ? 
ATOM   3093 N N     . ARG A 1 399 ? 10.972  24.046  33.754 1.00 68.47  ? 401  ARG A N     1 ? 
ATOM   3094 C CA    . ARG A 1 399 ? 10.982  23.216  34.981 1.00 71.01  ? 401  ARG A CA    1 ? 
ATOM   3095 C C     . ARG A 1 399 ? 12.364  22.590  35.115 1.00 64.30  ? 401  ARG A C     1 ? 
ATOM   3096 O O     . ARG A 1 399 ? 13.019  22.374  34.084 1.00 62.97  ? 401  ARG A O     1 ? 
ATOM   3097 C CB    . ARG A 1 399 ? 9.923   22.111  34.878 1.00 76.04  ? 401  ARG A CB    1 ? 
ATOM   3098 C CG    . ARG A 1 399 ? 10.286  21.035  33.858 1.00 82.17  ? 401  ARG A CG    1 ? 
ATOM   3099 C CD    . ARG A 1 399 ? 9.092   20.514  33.113 1.00 78.95  ? 401  ARG A CD    1 ? 
ATOM   3100 N NE    . ARG A 1 399 ? 9.371   20.096  31.749 1.00 81.14  ? 401  ARG A NE    1 ? 
ATOM   3101 C CZ    . ARG A 1 399 ? 9.469   18.835  31.360 1.00 86.37  ? 401  ARG A CZ    1 ? 
ATOM   3102 N NH1   . ARG A 1 399 ? 9.351   17.859  32.243 1.00 91.40  ? 401  ARG A NH1   1 ? 
ATOM   3103 N NH2   . ARG A 1 399 ? 9.713   18.549  30.094 1.00 92.94  ? 401  ARG A NH2   1 ? 
ATOM   3104 N N     . ILE A 1 400 ? 12.765  22.262  36.337 1.00 61.31  ? 402  ILE A N     1 ? 
ATOM   3105 C CA    . ILE A 1 400 ? 14.008  21.473  36.539 1.00 65.85  ? 402  ILE A CA    1 ? 
ATOM   3106 C C     . ILE A 1 400 ? 13.706  20.022  36.139 1.00 69.86  ? 402  ILE A C     1 ? 
ATOM   3107 O O     . ILE A 1 400 ? 12.577  19.528  36.407 1.00 64.57  ? 402  ILE A O     1 ? 
ATOM   3108 C CB    . ILE A 1 400 ? 14.543  21.609  37.971 1.00 66.19  ? 402  ILE A CB    1 ? 
ATOM   3109 C CG1   . ILE A 1 400 ? 14.903  23.067  38.276 1.00 69.80  ? 402  ILE A CG1   1 ? 
ATOM   3110 C CG2   . ILE A 1 400 ? 15.726  20.671  38.196 1.00 63.87  ? 402  ILE A CG2   1 ? 
ATOM   3111 C CD1   . ILE A 1 400 ? 15.474  23.284  39.670 1.00 69.24  ? 402  ILE A CD1   1 ? 
ATOM   3112 N N     . GLU A 1 401 ? 14.666  19.382  35.485 1.00 65.95  ? 403  GLU A N     1 ? 
ATOM   3113 C CA    . GLU A 1 401 ? 14.518  17.983  35.027 1.00 72.05  ? 403  GLU A CA    1 ? 
ATOM   3114 C C     . GLU A 1 401 ? 15.684  17.148  35.582 1.00 69.74  ? 403  GLU A C     1 ? 
ATOM   3115 O O     . GLU A 1 401 ? 16.679  17.711  36.075 1.00 67.48  ? 403  GLU A O     1 ? 
ATOM   3116 C CB    . GLU A 1 401 ? 14.422  17.923  33.494 1.00 68.84  ? 403  GLU A CB    1 ? 
ATOM   3117 C CG    . GLU A 1 401 ? 13.288  18.742  32.903 1.00 72.06  ? 403  GLU A CG    1 ? 
ATOM   3118 C CD    . GLU A 1 401 ? 13.253  18.688  31.382 1.00 73.86  ? 403  GLU A CD    1 ? 
ATOM   3119 O OE1   . GLU A 1 401 ? 13.155  17.593  30.853 1.00 78.21  ? 403  GLU A OE1   1 ? 
ATOM   3120 O OE2   . GLU A 1 401 ? 13.386  19.747  30.725 1.00 82.99  ? 403  GLU A OE2   1 ? 
ATOM   3121 N N     . SER A 1 402 ? 15.542  15.835  35.484 1.00 68.64  ? 404  SER A N     1 ? 
ATOM   3122 C CA    . SER A 1 402 ? 16.604  14.871  35.840 1.00 69.17  ? 404  SER A CA    1 ? 
ATOM   3123 C C     . SER A 1 402 ? 16.504  13.637  34.953 1.00 71.13  ? 404  SER A C     1 ? 
ATOM   3124 O O     . SER A 1 402 ? 15.398  13.333  34.440 1.00 63.55  ? 404  SER A O     1 ? 
ATOM   3125 C CB    . SER A 1 402 ? 16.529  14.496  37.288 1.00 68.22  ? 404  SER A CB    1 ? 
ATOM   3126 O OG    . SER A 1 402 ? 15.231  14.052  37.632 1.00 69.94  ? 404  SER A OG    1 ? 
ATOM   3127 N N     . LEU A 1 403 ? 17.635  12.963  34.786 1.00 68.23  ? 405  LEU A N     1 ? 
ATOM   3128 C CA    . LEU A 1 403 ? 17.732  11.738  33.974 1.00 61.80  ? 405  LEU A CA    1 ? 
ATOM   3129 C C     . LEU A 1 403 ? 18.126  10.598  34.896 1.00 64.92  ? 405  LEU A C     1 ? 
ATOM   3130 O O     . LEU A 1 403 ? 19.021  10.793  35.734 1.00 68.36  ? 405  LEU A O     1 ? 
ATOM   3131 C CB    . LEU A 1 403 ? 18.768  11.908  32.862 1.00 62.54  ? 405  LEU A CB    1 ? 
ATOM   3132 C CG    . LEU A 1 403 ? 18.581  13.096  31.928 1.00 63.88  ? 405  LEU A CG    1 ? 
ATOM   3133 C CD1   . LEU A 1 403 ? 19.800  13.235  31.031 1.00 64.79  ? 405  LEU A CD1   1 ? 
ATOM   3134 C CD2   . LEU A 1 403 ? 17.328  12.965  31.087 1.00 61.13  ? 405  LEU A CD2   1 ? 
ATOM   3135 N N     . MET A 1 404 ? 17.506  9.434   34.712 1.00 58.89  ? 406  MET A N     1 ? 
ATOM   3136 C CA    . MET A 1 404 ? 17.765  8.275   35.596 1.00 57.73  ? 406  MET A CA    1 ? 
ATOM   3137 C C     . MET A 1 404 ? 19.113  7.627   35.269 1.00 56.75  ? 406  MET A C     1 ? 
ATOM   3138 O O     . MET A 1 404 ? 19.646  6.927   36.139 1.00 58.05  ? 406  MET A O     1 ? 
ATOM   3139 C CB    . MET A 1 404 ? 16.641  7.246   35.501 1.00 62.39  ? 406  MET A CB    1 ? 
ATOM   3140 C CG    . MET A 1 404 ? 16.514  6.551   34.151 1.00 65.81  ? 406  MET A CG    1 ? 
ATOM   3141 S SD    . MET A 1 404 ? 15.512  5.019   34.287 1.00 64.96  ? 406  MET A SD    1 ? 
ATOM   3142 C CE    . MET A 1 404 ? 15.505  4.470   32.588 1.00 55.10  ? 406  MET A CE    1 ? 
ATOM   3143 N N     . GLN A 1 405 ? 19.657  7.863   34.080 1.00 60.71  ? 407  GLN A N     1 ? 
ATOM   3144 C CA    . GLN A 1 405 ? 21.013  7.366   33.742 1.00 64.25  ? 407  GLN A CA    1 ? 
ATOM   3145 C C     . GLN A 1 405 ? 22.087  8.213   34.442 1.00 62.69  ? 407  GLN A C     1 ? 
ATOM   3146 O O     . GLN A 1 405 ? 23.207  7.711   34.627 1.00 68.37  ? 407  GLN A O     1 ? 
ATOM   3147 C CB    . GLN A 1 405 ? 21.246  7.373   32.237 1.00 63.11  ? 407  GLN A CB    1 ? 
ATOM   3148 C CG    . GLN A 1 405 ? 21.067  8.739   31.603 1.00 66.05  ? 407  GLN A CG    1 ? 
ATOM   3149 C CD    . GLN A 1 405 ? 19.691  8.925   31.039 1.00 62.85  ? 407  GLN A CD    1 ? 
ATOM   3150 O OE1   . GLN A 1 405 ? 18.702  8.747   31.739 1.00 65.68  ? 407  GLN A OE1   1 ? 
ATOM   3151 N NE2   . GLN A 1 405 ? 19.641  9.347   29.785 1.00 67.10  ? 407  GLN A NE2   1 ? 
ATOM   3152 N N     . ASP A 1 406 ? 21.756  9.431   34.841 1.00 62.48  ? 408  ASP A N     1 ? 
ATOM   3153 C CA    . ASP A 1 406 ? 22.740  10.349  35.475 1.00 72.67  ? 408  ASP A CA    1 ? 
ATOM   3154 C C     . ASP A 1 406 ? 23.163  9.830   36.853 1.00 73.89  ? 408  ASP A C     1 ? 
ATOM   3155 O O     . ASP A 1 406 ? 24.142  10.346  37.381 1.00 79.00  ? 408  ASP A O     1 ? 
ATOM   3156 C CB    . ASP A 1 406 ? 22.197  11.778  35.554 1.00 67.71  ? 408  ASP A CB    1 ? 
ATOM   3157 C CG    . ASP A 1 406 ? 22.188  12.467  34.199 1.00 70.41  ? 408  ASP A CG    1 ? 
ATOM   3158 O OD1   . ASP A 1 406 ? 22.883  11.977  33.283 1.00 64.25  ? 408  ASP A OD1   1 ? 
ATOM   3159 O OD2   . ASP A 1 406 ? 21.468  13.478  34.056 1.00 79.53  ? 408  ASP A OD2   1 ? 
ATOM   3160 N N     . ILE A 1 407 ? 22.497  8.812   37.397 1.00 68.26  ? 409  ILE A N     1 ? 
ATOM   3161 C CA    . ILE A 1 407 ? 23.003  8.140   38.623 1.00 68.19  ? 409  ILE A CA    1 ? 
ATOM   3162 C C     . ILE A 1 407 ? 24.412  7.590   38.361 1.00 65.24  ? 409  ILE A C     1 ? 
ATOM   3163 O O     . ILE A 1 407 ? 25.116  7.319   39.336 1.00 69.72  ? 409  ILE A O     1 ? 
ATOM   3164 C CB    . ILE A 1 407 ? 22.034  7.040   39.074 1.00 64.86  ? 409  ILE A CB    1 ? 
ATOM   3165 C CG1   . ILE A 1 407 ? 22.200  6.780   40.569 1.00 71.74  ? 409  ILE A CG1   1 ? 
ATOM   3166 C CG2   . ILE A 1 407 ? 22.238  5.776   38.261 1.00 65.57  ? 409  ILE A CG2   1 ? 
ATOM   3167 C CD1   . ILE A 1 407 ? 21.418  5.601   41.075 1.00 67.24  ? 409  ILE A CD1   1 ? 
ATOM   3168 N N     . ALA A 1 408 ? 24.809  7.417   37.104 1.00 64.34  ? 410  ALA A N     1 ? 
ATOM   3169 C CA    . ALA A 1 408 ? 26.177  6.966   36.752 1.00 70.90  ? 410  ALA A CA    1 ? 
ATOM   3170 C C     . ALA A 1 408 ? 27.213  7.975   37.256 1.00 78.28  ? 410  ALA A C     1 ? 
ATOM   3171 O O     . ALA A 1 408 ? 28.372  7.558   37.441 1.00 76.39  ? 410  ALA A O     1 ? 
ATOM   3172 C CB    . ALA A 1 408 ? 26.308  6.775   35.264 1.00 68.05  ? 410  ALA A CB    1 ? 
ATOM   3173 N N     . LEU A 1 409 ? 26.818  9.240   37.458 1.00 79.38  ? 411  LEU A N     1 ? 
ATOM   3174 C CA    . LEU A 1 409 ? 27.745  10.307  37.933 1.00 77.25  ? 411  LEU A CA    1 ? 
ATOM   3175 C C     . LEU A 1 409 ? 28.138  10.032  39.388 1.00 87.31  ? 411  LEU A C     1 ? 
ATOM   3176 O O     . LEU A 1 409 ? 29.119  10.644  39.853 1.00 82.11  ? 411  LEU A O     1 ? 
ATOM   3177 C CB    . LEU A 1 409 ? 27.092  11.685  37.804 1.00 68.18  ? 411  LEU A CB    1 ? 
ATOM   3178 C CG    . LEU A 1 409 ? 26.761  12.110  36.381 1.00 67.62  ? 411  LEU A CG    1 ? 
ATOM   3179 C CD1   . LEU A 1 409 ? 25.994  13.412  36.364 1.00 74.25  ? 411  LEU A CD1   1 ? 
ATOM   3180 C CD2   . LEU A 1 409 ? 28.023  12.230  35.556 1.00 79.00  ? 411  LEU A CD2   1 ? 
ATOM   3181 N N     . LEU A 1 410 ? 27.411  9.151   40.084 1.00 79.54  ? 412  LEU A N     1 ? 
ATOM   3182 C CA    . LEU A 1 410 ? 27.734  8.806   41.492 1.00 69.29  ? 412  LEU A CA    1 ? 
ATOM   3183 C C     . LEU A 1 410 ? 28.668  7.596   41.554 1.00 69.79  ? 412  LEU A C     1 ? 
ATOM   3184 O O     . LEU A 1 410 ? 28.956  7.135   42.680 1.00 65.53  ? 412  LEU A O     1 ? 
ATOM   3185 C CB    . LEU A 1 410 ? 26.432  8.526   42.236 1.00 69.26  ? 412  LEU A CB    1 ? 
ATOM   3186 C CG    . LEU A 1 410 ? 25.418  9.663   42.200 1.00 74.39  ? 412  LEU A CG    1 ? 
ATOM   3187 C CD1   . LEU A 1 410 ? 24.105  9.230   42.826 1.00 74.64  ? 412  LEU A CD1   1 ? 
ATOM   3188 C CD2   . LEU A 1 410 ? 25.953  10.888  42.905 1.00 73.04  ? 412  LEU A CD2   1 ? 
ATOM   3189 N N     . PHE A 1 411 ? 29.105  7.077   40.406 1.00 69.57  ? 413  PHE A N     1 ? 
ATOM   3190 C CA    . PHE A 1 411 ? 29.932  5.848   40.361 1.00 79.80  ? 413  PHE A CA    1 ? 
ATOM   3191 C C     . PHE A 1 411 ? 31.349  6.236   39.972 1.00 91.40  ? 413  PHE A C     1 ? 
ATOM   3192 O O     . PHE A 1 411 ? 31.598  6.477   38.764 1.00 90.45  ? 413  PHE A O     1 ? 
ATOM   3193 C CB    . PHE A 1 411 ? 29.357  4.814   39.397 1.00 81.88  ? 413  PHE A CB    1 ? 
ATOM   3194 C CG    . PHE A 1 411 ? 28.158  4.076   39.937 1.00 82.58  ? 413  PHE A CG    1 ? 
ATOM   3195 C CD1   . PHE A 1 411 ? 26.884  4.616   39.822 1.00 80.79  ? 413  PHE A CD1   1 ? 
ATOM   3196 C CD2   . PHE A 1 411 ? 28.305  2.850   40.570 1.00 79.64  ? 413  PHE A CD2   1 ? 
ATOM   3197 C CE1   . PHE A 1 411 ? 25.782  3.938   40.316 1.00 78.69  ? 413  PHE A CE1   1 ? 
ATOM   3198 C CE2   . PHE A 1 411 ? 27.201  2.171   41.066 1.00 79.30  ? 413  PHE A CE2   1 ? 
ATOM   3199 C CZ    . PHE A 1 411 ? 25.942  2.715   40.929 1.00 78.67  ? 413  PHE A CZ    1 ? 
ATOM   3200 N N     . SER A 1 412 ? 32.241  6.308   40.966 1.00 89.70  ? 414  SER A N     1 ? 
ATOM   3201 C CA    . SER A 1 412 ? 33.662  6.648   40.725 1.00 79.65  ? 414  SER A CA    1 ? 
ATOM   3202 C C     . SER A 1 412 ? 34.339  5.501   39.986 1.00 74.47  ? 414  SER A C     1 ? 
ATOM   3203 O O     . SER A 1 412 ? 34.013  4.339   40.265 1.00 83.38  ? 414  SER A O     1 ? 
ATOM   3204 C CB    . SER A 1 412 ? 34.367  6.961   42.013 1.00 82.05  ? 414  SER A CB    1 ? 
ATOM   3205 O OG    . SER A 1 412 ? 34.954  5.802   42.594 1.00 82.70  ? 414  SER A OG    1 ? 
ATOM   3206 N N     . GLU A 1 413 ? 35.258  5.834   39.091 1.00 72.59  ? 415  GLU A N     1 ? 
ATOM   3207 C CA    . GLU A 1 413 ? 36.081  4.823   38.387 1.00 81.25  ? 415  GLU A CA    1 ? 
ATOM   3208 C C     . GLU A 1 413 ? 37.001  4.099   39.371 1.00 88.14  ? 415  GLU A C     1 ? 
ATOM   3209 O O     . GLU A 1 413 ? 37.440  2.979   39.047 1.00 95.30  ? 415  GLU A O     1 ? 
ATOM   3210 C CB    . GLU A 1 413 ? 36.908  5.472   37.288 1.00 82.05  ? 415  GLU A CB    1 ? 
ATOM   3211 C CG    . GLU A 1 413 ? 36.460  5.055   35.912 1.00 93.10  ? 415  GLU A CG    1 ? 
ATOM   3212 C CD    . GLU A 1 413 ? 37.363  5.561   34.803 1.00 104.96 ? 415  GLU A CD    1 ? 
ATOM   3213 O OE1   . GLU A 1 413 ? 38.612  5.554   35.016 1.00 108.87 ? 415  GLU A OE1   1 ? 
ATOM   3214 O OE2   . GLU A 1 413 ? 36.827  5.954   33.730 1.00 98.49  ? 415  GLU A OE2   1 ? 
ATOM   3215 N N     . ASP A 1 414 ? 37.290  4.706   40.519 1.00 89.59  ? 416  ASP A N     1 ? 
ATOM   3216 C CA    . ASP A 1 414 ? 38.216  4.105   41.509 1.00 97.26  ? 416  ASP A CA    1 ? 
ATOM   3217 C C     . ASP A 1 414 ? 37.523  2.932   42.195 1.00 96.82  ? 416  ASP A C     1 ? 
ATOM   3218 O O     . ASP A 1 414 ? 38.173  1.880   42.354 1.00 104.32 ? 416  ASP A O     1 ? 
ATOM   3219 C CB    . ASP A 1 414 ? 38.711  5.148   42.512 1.00 100.37 ? 416  ASP A CB    1 ? 
ATOM   3220 C CG    . ASP A 1 414 ? 39.696  6.137   41.899 1.00 106.30 ? 416  ASP A CG    1 ? 
ATOM   3221 O OD1   . ASP A 1 414 ? 40.432  5.731   40.964 1.00 103.95 ? 416  ASP A OD1   1 ? 
ATOM   3222 O OD2   . ASP A 1 414 ? 39.714  7.305   42.345 1.00 95.29  ? 416  ASP A OD2   1 ? 
ATOM   3223 N N     . ASP A 1 415 ? 36.256  3.106   42.546 1.00 93.66  ? 417  ASP A N     1 ? 
ATOM   3224 C CA    . ASP A 1 415 ? 35.546  2.111   43.398 1.00 104.21 ? 417  ASP A CA    1 ? 
ATOM   3225 C C     . ASP A 1 415 ? 34.594  1.223   42.589 1.00 98.49  ? 417  ASP A C     1 ? 
ATOM   3226 O O     . ASP A 1 415 ? 34.231  0.149   43.115 1.00 88.08  ? 417  ASP A O     1 ? 
ATOM   3227 C CB    . ASP A 1 415 ? 34.777  2.812   44.516 1.00 104.92 ? 417  ASP A CB    1 ? 
ATOM   3228 C CG    . ASP A 1 415 ? 35.690  3.613   45.431 1.00 107.63 ? 417  ASP A CG    1 ? 
ATOM   3229 O OD1   . ASP A 1 415 ? 36.464  4.465   44.896 1.00 107.93 ? 417  ASP A OD1   1 ? 
ATOM   3230 O OD2   . ASP A 1 415 ? 35.652  3.367   46.657 1.00 94.12  ? 417  ASP A OD2   1 ? 
ATOM   3231 N N     . TYR A 1 416 ? 34.189  1.632   41.409 1.00 88.14  ? 418  TYR A N     1 ? 
ATOM   3232 C CA    . TYR A 1 416 ? 33.130  0.934   40.640 1.00 83.05  ? 418  TYR A CA    1 ? 
ATOM   3233 C C     . TYR A 1 416 ? 33.557  0.786   39.189 1.00 83.54  ? 418  TYR A C     1 ? 
ATOM   3234 O O     . TYR A 1 416 ? 34.314  1.610   38.662 1.00 89.97  ? 418  TYR A O     1 ? 
ATOM   3235 C CB    . TYR A 1 416 ? 31.797  1.677   40.743 1.00 74.97  ? 418  TYR A CB    1 ? 
ATOM   3236 C CG    . TYR A 1 416 ? 31.202  1.673   42.126 1.00 74.16  ? 418  TYR A CG    1 ? 
ATOM   3237 C CD1   . TYR A 1 416 ? 30.672  0.516   42.668 1.00 76.78  ? 418  TYR A CD1   1 ? 
ATOM   3238 C CD2   . TYR A 1 416 ? 31.167  2.823   42.892 1.00 68.99  ? 418  TYR A CD2   1 ? 
ATOM   3239 C CE1   . TYR A 1 416 ? 30.121  0.503   43.939 1.00 80.22  ? 418  TYR A CE1   1 ? 
ATOM   3240 C CE2   . TYR A 1 416 ? 30.623  2.828   44.163 1.00 71.00  ? 418  TYR A CE2   1 ? 
ATOM   3241 C CZ    . TYR A 1 416 ? 30.093  1.666   44.688 1.00 76.78  ? 418  TYR A CZ    1 ? 
ATOM   3242 O OH    . TYR A 1 416 ? 29.544  1.661   45.940 1.00 84.58  ? 418  TYR A OH    1 ? 
ATOM   3243 N N     . ARG A 1 417 ? 33.062  -0.266  38.562 1.00 76.99  ? 419  ARG A N     1 ? 
ATOM   3244 C CA    . ARG A 1 417 ? 33.249  -0.472  37.114 1.00 77.84  ? 419  ARG A CA    1 ? 
ATOM   3245 C C     . ARG A 1 417 ? 31.926  -0.167  36.435 1.00 84.86  ? 419  ARG A C     1 ? 
ATOM   3246 O O     . ARG A 1 417 ? 30.915  -0.859  36.747 1.00 79.76  ? 419  ARG A O     1 ? 
ATOM   3247 C CB    . ARG A 1 417 ? 33.681  -1.908  36.821 1.00 87.16  ? 419  ARG A CB    1 ? 
ATOM   3248 C CG    . ARG A 1 417 ? 35.152  -2.177  37.102 1.00 84.90  ? 419  ARG A CG    1 ? 
ATOM   3249 C CD    . ARG A 1 417 ? 35.458  -3.662  37.133 1.00 75.65  ? 419  ARG A CD    1 ? 
ATOM   3250 N NE    . ARG A 1 417 ? 35.403  -4.263  35.814 1.00 78.06  ? 419  ARG A NE    1 ? 
ATOM   3251 C CZ    . ARG A 1 417 ? 36.380  -4.212  34.911 1.00 81.46  ? 419  ARG A CZ    1 ? 
ATOM   3252 N NH1   . ARG A 1 417 ? 37.513  -3.584  35.176 1.00 83.04  ? 419  ARG A NH1   1 ? 
ATOM   3253 N NH2   . ARG A 1 417 ? 36.230  -4.799  33.741 1.00 78.80  ? 419  ARG A NH2   1 ? 
ATOM   3254 N N     . VAL A 1 418 ? 31.954  0.831   35.557 1.00 80.55  ? 420  VAL A N     1 ? 
ATOM   3255 C CA    . VAL A 1 418 ? 30.786  1.252   34.745 1.00 73.08  ? 420  VAL A CA    1 ? 
ATOM   3256 C C     . VAL A 1 418 ? 31.138  1.052   33.280 1.00 76.99  ? 420  VAL A C     1 ? 
ATOM   3257 O O     . VAL A 1 418 ? 32.141  1.614   32.828 1.00 80.31  ? 420  VAL A O     1 ? 
ATOM   3258 C CB    . VAL A 1 418 ? 30.382  2.706   35.016 1.00 69.01  ? 420  VAL A CB    1 ? 
ATOM   3259 C CG1   . VAL A 1 418 ? 29.329  3.156   34.013 1.00 68.86  ? 420  VAL A CG1   1 ? 
ATOM   3260 C CG2   . VAL A 1 418 ? 29.883  2.869   36.446 1.00 68.14  ? 420  VAL A CG2   1 ? 
ATOM   3261 N N     . GLY A 1 419 ? 30.318  0.288   32.571 1.00 78.82  ? 421  GLY A N     1 ? 
ATOM   3262 C CA    . GLY A 1 419 ? 30.595  -0.037  31.170 1.00 78.01  ? 421  GLY A CA    1 ? 
ATOM   3263 C C     . GLY A 1 419 ? 29.342  -0.025  30.328 1.00 74.44  ? 421  GLY A C     1 ? 
ATOM   3264 O O     . GLY A 1 419 ? 28.285  0.393   30.819 1.00 68.10  ? 421  GLY A O     1 ? 
ATOM   3265 N N     . GLY A 1 420 ? 29.496  -0.440  29.078 1.00 68.82  ? 422  GLY A N     1 ? 
ATOM   3266 C CA    . GLY A 1 420 ? 28.404  -0.459  28.104 1.00 67.92  ? 422  GLY A CA    1 ? 
ATOM   3267 C C     . GLY A 1 420 ? 28.487  -1.680  27.210 1.00 69.63  ? 422  GLY A C     1 ? 
ATOM   3268 O O     . GLY A 1 420 ? 29.619  -2.092  26.849 1.00 66.40  ? 422  GLY A O     1 ? 
ATOM   3269 N N     . THR A 1 421 ? 27.325  -2.233  26.849 1.00 60.24  ? 423  THR A N     1 ? 
ATOM   3270 C CA    . THR A 1 421 ? 27.249  -3.351  25.882 1.00 56.76  ? 423  THR A CA    1 ? 
ATOM   3271 C C     . THR A 1 421 ? 26.620  -2.858  24.588 1.00 56.13  ? 423  THR A C     1 ? 
ATOM   3272 O O     . THR A 1 421 ? 25.602  -2.170  24.647 1.00 65.96  ? 423  THR A O     1 ? 
ATOM   3273 C CB    . THR A 1 421 ? 26.451  -4.512  26.464 1.00 62.61  ? 423  THR A CB    1 ? 
ATOM   3274 O OG1   . THR A 1 421 ? 26.873  -4.700  27.817 1.00 63.30  ? 423  THR A OG1   1 ? 
ATOM   3275 C CG2   . THR A 1 421 ? 26.644  -5.760  25.643 1.00 61.58  ? 423  THR A CG2   1 ? 
ATOM   3276 N N     . VAL A 1 422 ? 27.238  -3.197  23.468 1.00 57.52  ? 424  VAL A N     1 ? 
ATOM   3277 C CA    . VAL A 1 422 ? 26.809  -2.686  22.146 1.00 58.35  ? 424  VAL A CA    1 ? 
ATOM   3278 C C     . VAL A 1 422 ? 26.099  -3.814  21.428 1.00 57.00  ? 424  VAL A C     1 ? 
ATOM   3279 O O     . VAL A 1 422 ? 26.738  -4.816  21.143 1.00 65.03  ? 424  VAL A O     1 ? 
ATOM   3280 C CB    . VAL A 1 422 ? 27.974  -2.137  21.305 1.00 61.59  ? 424  VAL A CB    1 ? 
ATOM   3281 C CG1   . VAL A 1 422 ? 27.459  -1.541  19.997 1.00 58.34  ? 424  VAL A CG1   1 ? 
ATOM   3282 C CG2   . VAL A 1 422 ? 28.777  -1.106  22.087 1.00 62.30  ? 424  VAL A CG2   1 ? 
ATOM   3283 N N     . PHE A 1 423 ? 24.822  -3.599  21.157 1.00 63.50  ? 425  PHE A N     1 ? 
ATOM   3284 C CA    . PHE A 1 423 ? 23.958  -4.533  20.409 1.00 59.27  ? 425  PHE A CA    1 ? 
ATOM   3285 C C     . PHE A 1 423 ? 23.706  -3.962  19.021 1.00 54.17  ? 425  PHE A C     1 ? 
ATOM   3286 O O     . PHE A 1 423 ? 24.050  -2.810  18.750 1.00 56.69  ? 425  PHE A O     1 ? 
ATOM   3287 C CB    . PHE A 1 423 ? 22.627  -4.735  21.132 1.00 57.00  ? 425  PHE A CB    1 ? 
ATOM   3288 C CG    . PHE A 1 423 ? 22.767  -5.403  22.471 1.00 53.57  ? 425  PHE A CG    1 ? 
ATOM   3289 C CD1   . PHE A 1 423 ? 23.077  -4.672  23.599 1.00 53.79  ? 425  PHE A CD1   1 ? 
ATOM   3290 C CD2   . PHE A 1 423 ? 22.570  -6.763  22.596 1.00 55.57  ? 425  PHE A CD2   1 ? 
ATOM   3291 C CE1   . PHE A 1 423 ? 23.192  -5.300  24.830 1.00 55.26  ? 425  PHE A CE1   1 ? 
ATOM   3292 C CE2   . PHE A 1 423 ? 22.683  -7.391  23.819 1.00 55.15  ? 425  PHE A CE2   1 ? 
ATOM   3293 C CZ    . PHE A 1 423 ? 22.982  -6.658  24.938 1.00 57.14  ? 425  PHE A CZ    1 ? 
ATOM   3294 N N     . GLU A 1 424 ? 23.051  -4.759  18.197 1.00 54.65  ? 426  GLU A N     1 ? 
ATOM   3295 C CA    . GLU A 1 424 ? 22.605  -4.323  16.866 1.00 61.82  ? 426  GLU A CA    1 ? 
ATOM   3296 C C     . GLU A 1 424 ? 21.563  -3.220  17.034 1.00 64.95  ? 426  GLU A C     1 ? 
ATOM   3297 O O     . GLU A 1 424 ? 20.814  -3.243  18.029 1.00 70.19  ? 426  GLU A O     1 ? 
ATOM   3298 C CB    . GLU A 1 424 ? 21.993  -5.477  16.086 1.00 65.21  ? 426  GLU A CB    1 ? 
ATOM   3299 C CG    . GLU A 1 424 ? 22.754  -6.761  16.193 1.00 77.49  ? 426  GLU A CG    1 ? 
ATOM   3300 C CD    . GLU A 1 424 ? 21.833  -7.961  16.365 1.00 84.11  ? 426  GLU A CD    1 ? 
ATOM   3301 O OE1   . GLU A 1 424 ? 21.752  -8.480  17.503 1.00 75.70  ? 426  GLU A OE1   1 ? 
ATOM   3302 O OE2   . GLU A 1 424 ? 21.187  -8.359  15.357 1.00 94.54  ? 426  GLU A OE2   1 ? 
ATOM   3303 N N     . ARG A 1 425 ? 21.506  -2.321  16.058 1.00 65.59  ? 427  ARG A N     1 ? 
ATOM   3304 C CA    . ARG A 1 425 ? 20.496  -1.231  16.044 1.00 64.44  ? 427  ARG A CA    1 ? 
ATOM   3305 C C     . ARG A 1 425 ? 19.095  -1.837  15.975 1.00 53.92  ? 427  ARG A C     1 ? 
ATOM   3306 O O     . ARG A 1 425 ? 18.150  -1.238  16.522 1.00 54.94  ? 427  ARG A O     1 ? 
ATOM   3307 C CB    . ARG A 1 425 ? 20.776  -0.272  14.887 1.00 63.46  ? 427  ARG A CB    1 ? 
ATOM   3308 C CG    . ARG A 1 425 ? 22.062  0.522   15.057 1.00 66.77  ? 427  ARG A CG    1 ? 
ATOM   3309 C CD    . ARG A 1 425 ? 22.291  1.449   13.873 1.00 66.41  ? 427  ARG A CD    1 ? 
ATOM   3310 N NE    . ARG A 1 425 ? 21.113  2.231   13.513 1.00 62.85  ? 427  ARG A NE    1 ? 
ATOM   3311 C CZ    . ARG A 1 425 ? 20.685  3.315   14.158 1.00 59.28  ? 427  ARG A CZ    1 ? 
ATOM   3312 N NH1   . ARG A 1 425 ? 21.327  3.773   15.214 1.00 65.08  ? 427  ARG A NH1   1 ? 
ATOM   3313 N NH2   . ARG A 1 425 ? 19.611  3.948   13.742 1.00 61.31  ? 427  ARG A NH2   1 ? 
ATOM   3314 N N     . PHE A 1 426 ? 18.931  -3.003  15.350 1.00 48.72  ? 428  PHE A N     1 ? 
ATOM   3315 C CA    . PHE A 1 426 ? 17.588  -3.621  15.188 1.00 53.84  ? 428  PHE A CA    1 ? 
ATOM   3316 C C     . PHE A 1 426 ? 17.004  -3.986  16.554 1.00 55.53  ? 428  PHE A C     1 ? 
ATOM   3317 O O     . PHE A 1 426 ? 15.787  -4.072  16.668 1.00 53.38  ? 428  PHE A O     1 ? 
ATOM   3318 C CB    . PHE A 1 426 ? 17.664  -4.848  14.282 1.00 50.44  ? 428  PHE A CB    1 ? 
ATOM   3319 C CG    . PHE A 1 426 ? 16.362  -5.566  14.045 1.00 55.11  ? 428  PHE A CG    1 ? 
ATOM   3320 C CD1   . PHE A 1 426 ? 15.358  -4.986  13.292 1.00 58.23  ? 428  PHE A CD1   1 ? 
ATOM   3321 C CD2   . PHE A 1 426 ? 16.139  -6.820  14.587 1.00 55.43  ? 428  PHE A CD2   1 ? 
ATOM   3322 C CE1   . PHE A 1 426 ? 14.163  -5.652  13.075 1.00 58.53  ? 428  PHE A CE1   1 ? 
ATOM   3323 C CE2   . PHE A 1 426 ? 14.944  -7.484  14.369 1.00 56.96  ? 428  PHE A CE2   1 ? 
ATOM   3324 C CZ    . PHE A 1 426 ? 13.960  -6.897  13.615 1.00 55.93  ? 428  PHE A CZ    1 ? 
ATOM   3325 N N     . SER A 1 427 ? 17.861  -4.200  17.545 1.00 55.57  ? 429  SER A N     1 ? 
ATOM   3326 C CA    . SER A 1 427 ? 17.402  -4.541  18.910 1.00 51.92  ? 429  SER A CA    1 ? 
ATOM   3327 C C     . SER A 1 427 ? 16.731  -3.369  19.605 1.00 51.20  ? 429  SER A C     1 ? 
ATOM   3328 O O     . SER A 1 427 ? 16.035  -3.621  20.570 1.00 53.22  ? 429  SER A O     1 ? 
ATOM   3329 C CB    . SER A 1 427 ? 18.549  -5.042  19.741 1.00 56.31  ? 429  SER A CB    1 ? 
ATOM   3330 O OG    . SER A 1 427 ? 19.361  -3.957  20.168 1.00 62.03  ? 429  SER A OG    1 ? 
ATOM   3331 N N     . TYR A 1 428 ? 16.962  -2.151  19.134 1.00 58.41  ? 430  TYR A N     1 ? 
ATOM   3332 C CA    . TYR A 1 428 ? 16.344  -0.921  19.675 1.00 54.07  ? 430  TYR A CA    1 ? 
ATOM   3333 C C     . TYR A 1 428 ? 15.112  -0.617  18.837 1.00 55.52  ? 430  TYR A C     1 ? 
ATOM   3334 O O     . TYR A 1 428 ? 15.259  -0.240  17.659 1.00 64.69  ? 430  TYR A O     1 ? 
ATOM   3335 C CB    . TYR A 1 428 ? 17.357  0.213   19.657 1.00 58.25  ? 430  TYR A CB    1 ? 
ATOM   3336 C CG    . TYR A 1 428 ? 16.865  1.532   20.167 1.00 53.65  ? 430  TYR A CG    1 ? 
ATOM   3337 C CD1   . TYR A 1 428 ? 16.346  1.641   21.435 1.00 56.05  ? 430  TYR A CD1   1 ? 
ATOM   3338 C CD2   . TYR A 1 428 ? 16.945  2.671   19.394 1.00 53.65  ? 430  TYR A CD2   1 ? 
ATOM   3339 C CE1   . TYR A 1 428 ? 15.922  2.856   21.939 1.00 55.84  ? 430  TYR A CE1   1 ? 
ATOM   3340 C CE2   . TYR A 1 428 ? 16.514  3.893   19.868 1.00 54.53  ? 430  TYR A CE2   1 ? 
ATOM   3341 C CZ    . TYR A 1 428 ? 16.011  3.988   21.150 1.00 58.61  ? 430  TYR A CZ    1 ? 
ATOM   3342 O OH    . TYR A 1 428 ? 15.546  5.191   21.584 1.00 62.88  ? 430  TYR A OH    1 ? 
ATOM   3343 N N     . GLN A 1 429 ? 13.931  -0.825  19.415 1.00 52.37  ? 431  GLN A N     1 ? 
ATOM   3344 C CA    . GLN A 1 429 ? 12.645  -0.697  18.664 1.00 55.60  ? 431  GLN A CA    1 ? 
ATOM   3345 C C     . GLN A 1 429 ? 11.660  0.192   19.410 1.00 51.49  ? 431  GLN A C     1 ? 
ATOM   3346 O O     . GLN A 1 429 ? 10.582  -0.235  19.751 1.00 65.06  ? 431  GLN A O     1 ? 
ATOM   3347 C CB    . GLN A 1 429 ? 12.016  -2.062  18.416 1.00 46.64  ? 431  GLN A CB    1 ? 
ATOM   3348 C CG    . GLN A 1 429 ? 13.022  -3.150  18.096 1.00 52.99  ? 431  GLN A CG    1 ? 
ATOM   3349 C CD    . GLN A 1 429 ? 12.338  -4.419  17.649 1.00 57.15  ? 431  GLN A CD    1 ? 
ATOM   3350 O OE1   . GLN A 1 429 ? 11.126  -4.607  17.842 1.00 55.72  ? 431  GLN A OE1   1 ? 
ATOM   3351 N NE2   . GLN A 1 429 ? 13.139  -5.310  17.092 1.00 57.80  ? 431  GLN A NE2   1 ? 
ATOM   3352 N N     . PRO A 1 430 ? 11.959  1.461   19.683 1.00 55.48  ? 432  PRO A N     1 ? 
ATOM   3353 C CA    . PRO A 1 430 ? 10.998  2.291   20.386 1.00 58.26  ? 432  PRO A CA    1 ? 
ATOM   3354 C C     . PRO A 1 430 ? 9.882   2.832   19.482 1.00 57.01  ? 432  PRO A C     1 ? 
ATOM   3355 O O     . PRO A 1 430 ? 10.038  2.929   18.271 1.00 58.51  ? 432  PRO A O     1 ? 
ATOM   3356 C CB    . PRO A 1 430 ? 11.878  3.440   20.893 1.00 56.68  ? 432  PRO A CB    1 ? 
ATOM   3357 C CG    . PRO A 1 430 ? 12.887  3.594   19.789 1.00 56.33  ? 432  PRO A CG    1 ? 
ATOM   3358 C CD    . PRO A 1 430 ? 13.192  2.177   19.346 1.00 57.36  ? 432  PRO A CD    1 ? 
ATOM   3359 N N     . VAL A 1 431 ? 8.785   3.203   20.122 1.00 55.14  ? 433  VAL A N     1 ? 
ATOM   3360 C CA    . VAL A 1 431 ? 7.668   3.928   19.469 1.00 58.88  ? 433  VAL A CA    1 ? 
ATOM   3361 C C     . VAL A 1 431 ? 7.653   5.344   20.046 1.00 62.83  ? 433  VAL A C     1 ? 
ATOM   3362 O O     . VAL A 1 431 ? 7.074   5.565   21.108 1.00 62.90  ? 433  VAL A O     1 ? 
ATOM   3363 C CB    . VAL A 1 431 ? 6.347   3.171   19.663 1.00 55.67  ? 433  VAL A CB    1 ? 
ATOM   3364 C CG1   . VAL A 1 431 ? 5.196   3.875   18.992 1.00 55.67  ? 433  VAL A CG1   1 ? 
ATOM   3365 C CG2   . VAL A 1 431 ? 6.456   1.753   19.121 1.00 53.29  ? 433  VAL A CG2   1 ? 
ATOM   3366 N N     . LYS A 1 432 ? 8.335   6.271   19.384 1.00 71.65  ? 434  LYS A N     1 ? 
ATOM   3367 C CA    . LYS A 1 432 ? 8.534   7.646   19.914 1.00 65.62  ? 434  LYS A CA    1 ? 
ATOM   3368 C C     . LYS A 1 432 ? 7.868   8.694   19.023 1.00 59.89  ? 434  LYS A C     1 ? 
ATOM   3369 O O     . LYS A 1 432 ? 7.482   9.708   19.567 1.00 65.61  ? 434  LYS A O     1 ? 
ATOM   3370 C CB    . LYS A 1 432 ? 10.027  7.925   20.046 1.00 68.15  ? 434  LYS A CB    1 ? 
ATOM   3371 C CG    . LYS A 1 432 ? 10.694  7.179   21.190 1.00 81.62  ? 434  LYS A CG    1 ? 
ATOM   3372 C CD    . LYS A 1 432 ? 11.717  8.005   21.919 1.00 77.77  ? 434  LYS A CD    1 ? 
ATOM   3373 C CE    . LYS A 1 432 ? 12.197  7.350   23.193 1.00 85.31  ? 434  LYS A CE    1 ? 
ATOM   3374 N NZ    . LYS A 1 432 ? 12.895  8.321   24.074 1.00 82.14  ? 434  LYS A NZ    1 ? 
ATOM   3375 N N     . ASN A 1 433 ? 7.729   8.449   17.719 1.00 61.27  ? 435  ASN A N     1 ? 
ATOM   3376 C CA    . ASN A 1 433 ? 7.367   9.515   16.759 1.00 59.90  ? 435  ASN A CA    1 ? 
ATOM   3377 C C     . ASN A 1 433 ? 6.023   9.227   16.114 1.00 48.22  ? 435  ASN A C     1 ? 
ATOM   3378 O O     . ASN A 1 433 ? 5.648   8.103   15.925 1.00 59.87  ? 435  ASN A O     1 ? 
ATOM   3379 C CB    . ASN A 1 433 ? 8.438   9.707   15.683 1.00 67.20  ? 435  ASN A CB    1 ? 
ATOM   3380 C CG    . ASN A 1 433 ? 9.795   10.027  16.260 1.00 63.18  ? 435  ASN A CG    1 ? 
ATOM   3381 O OD1   . ASN A 1 433 ? 9.911   10.897  17.118 1.00 69.92  ? 435  ASN A OD1   1 ? 
ATOM   3382 N ND2   . ASN A 1 433 ? 10.807  9.315   15.805 1.00 63.89  ? 435  ASN A ND2   1 ? 
ATOM   3383 N N     . SER A 1 434 ? 5.337   10.270  15.735 1.00 56.20  ? 436  SER A N     1 ? 
ATOM   3384 C CA    . SER A 1 434 ? 4.090   10.164  14.948 1.00 61.43  ? 436  SER A CA    1 ? 
ATOM   3385 C C     . SER A 1 434 ? 4.413   9.864   13.489 1.00 54.15  ? 436  SER A C     1 ? 
ATOM   3386 O O     . SER A 1 434 ? 5.579   9.945   13.103 1.00 59.80  ? 436  SER A O     1 ? 
ATOM   3387 C CB    . SER A 1 434 ? 3.291   11.418  15.031 1.00 62.22  ? 436  SER A CB    1 ? 
ATOM   3388 O OG    . SER A 1 434 ? 4.118   12.542  14.767 1.00 70.64  ? 436  SER A OG    1 ? 
ATOM   3389 N N     . LEU A 1 435 ? 3.390   9.493   12.735 1.00 56.61  ? 437  LEU A N     1 ? 
ATOM   3390 C CA    . LEU A 1 435 ? 3.522   9.230   11.275 1.00 62.21  ? 437  LEU A CA    1 ? 
ATOM   3391 C C     . LEU A 1 435 ? 4.065   10.447  10.523 1.00 58.51  ? 437  LEU A C     1 ? 
ATOM   3392 O O     . LEU A 1 435 ? 4.950   10.235  9.701  1.00 65.76  ? 437  LEU A O     1 ? 
ATOM   3393 C CB    . LEU A 1 435 ? 2.161   8.848   10.702 1.00 64.56  ? 437  LEU A CB    1 ? 
ATOM   3394 C CG    . LEU A 1 435 ? 1.778   7.393   10.870 1.00 58.87  ? 437  LEU A CG    1 ? 
ATOM   3395 C CD1   . LEU A 1 435 ? 0.595   7.059   9.976  1.00 57.91  ? 437  LEU A CD1   1 ? 
ATOM   3396 C CD2   . LEU A 1 435 ? 2.955   6.480   10.558 1.00 65.97  ? 437  LEU A CD2   1 ? 
ATOM   3397 N N     . GLU A 1 436 ? 3.627   11.653  10.873 1.00 68.70  ? 438  GLU A N     1 ? 
ATOM   3398 C CA    . GLU A 1 436 ? 4.112   12.904  10.231 1.00 76.05  ? 438  GLU A CA    1 ? 
ATOM   3399 C C     . GLU A 1 436 ? 5.606   13.097  10.512 1.00 77.98  ? 438  GLU A C     1 ? 
ATOM   3400 O O     . GLU A 1 436 ? 6.341   13.360  9.556  1.00 87.48  ? 438  GLU A O     1 ? 
ATOM   3401 C CB    . GLU A 1 436 ? 3.272   14.085  10.720 1.00 88.02  ? 438  GLU A CB    1 ? 
ATOM   3402 C CG    . GLU A 1 436 ? 3.713   15.428  10.178 1.00 100.48 ? 438  GLU A CG    1 ? 
ATOM   3403 C CD    . GLU A 1 436 ? 2.783   16.571  10.544 1.00 104.86 ? 438  GLU A CD    1 ? 
ATOM   3404 O OE1   . GLU A 1 436 ? 1.741   16.304  11.166 1.00 97.71  ? 438  GLU A OE1   1 ? 
ATOM   3405 O OE2   . GLU A 1 436 ? 3.110   17.724  10.217 1.00 103.75 ? 438  GLU A OE2   1 ? 
ATOM   3406 N N     . GLU A 1 437 ? 6.031   12.961  11.767 1.00 71.75  ? 439  GLU A N     1 ? 
ATOM   3407 C CA    . GLU A 1 437 ? 7.463   13.095  12.142 1.00 67.18  ? 439  GLU A CA    1 ? 
ATOM   3408 C C     . GLU A 1 437 ? 8.255   11.967  11.476 1.00 69.20  ? 439  GLU A C     1 ? 
ATOM   3409 O O     . GLU A 1 437 ? 9.392   12.216  11.009 1.00 77.74  ? 439  GLU A O     1 ? 
ATOM   3410 C CB    . GLU A 1 437 ? 7.642   13.072  13.658 1.00 71.13  ? 439  GLU A CB    1 ? 
ATOM   3411 C CG    . GLU A 1 437 ? 6.990   14.239  14.381 1.00 84.06  ? 439  GLU A CG    1 ? 
ATOM   3412 C CD    . GLU A 1 437 ? 6.837   14.058  15.897 1.00 98.93  ? 439  GLU A CD    1 ? 
ATOM   3413 O OE1   . GLU A 1 437 ? 6.827   12.896  16.415 1.00 86.00  ? 439  GLU A OE1   1 ? 
ATOM   3414 O OE2   . GLU A 1 437 ? 6.727   15.092  16.588 1.00 104.69 ? 439  GLU A OE2   1 ? 
ATOM   3415 N N     . ALA A 1 438 ? 7.697   10.767  11.428 1.00 70.18  ? 440  ALA A N     1 ? 
ATOM   3416 C CA    . ALA A 1 438 ? 8.399   9.608   10.839 1.00 76.57  ? 440  ALA A CA    1 ? 
ATOM   3417 C C     . ALA A 1 438 ? 8.635   9.882   9.343  1.00 68.82  ? 440  ALA A C     1 ? 
ATOM   3418 O O     . ALA A 1 438 ? 9.703   9.537   8.836  1.00 67.40  ? 440  ALA A O     1 ? 
ATOM   3419 C CB    . ALA A 1 438 ? 7.614   8.335   11.064 1.00 73.05  ? 440  ALA A CB    1 ? 
ATOM   3420 N N     . ALA A 1 439 ? 7.652   10.437  8.645  1.00 65.52  ? 441  ALA A N     1 ? 
ATOM   3421 C CA    . ALA A 1 439 ? 7.791   10.721  7.200  1.00 77.05  ? 441  ALA A CA    1 ? 
ATOM   3422 C C     . ALA A 1 439 ? 8.867   11.793  7.014  1.00 81.23  ? 441  ALA A C     1 ? 
ATOM   3423 O O     . ALA A 1 439 ? 9.762   11.625  6.135  1.00 74.99  ? 441  ALA A O     1 ? 
ATOM   3424 C CB    . ALA A 1 439 ? 6.481   11.149  6.601  1.00 73.76  ? 441  ALA A CB    1 ? 
ATOM   3425 N N     . GLY A 1 440 ? 8.823   12.826  7.852  1.00 77.67  ? 442  GLY A N     1 ? 
ATOM   3426 C CA    . GLY A 1 440 ? 9.848   13.886  7.842  1.00 78.16  ? 442  GLY A CA    1 ? 
ATOM   3427 C C     . GLY A 1 440 ? 11.234  13.323  8.088  1.00 81.38  ? 442  GLY A C     1 ? 
ATOM   3428 O O     . GLY A 1 440 ? 12.170  13.714  7.364  1.00 93.25  ? 442  GLY A O     1 ? 
ATOM   3429 N N     . LEU A 1 441 ? 11.374  12.431  9.066  1.00 81.69  ? 443  LEU A N     1 ? 
ATOM   3430 C CA    . LEU A 1 441 ? 12.692  11.839  9.419  1.00 82.62  ? 443  LEU A CA    1 ? 
ATOM   3431 C C     . LEU A 1 441 ? 13.181  10.897  8.315  1.00 84.83  ? 443  LEU A C     1 ? 
ATOM   3432 O O     . LEU A 1 441 ? 14.421  10.791  8.104  1.00 78.27  ? 443  LEU A O     1 ? 
ATOM   3433 C CB    . LEU A 1 441 ? 12.573  11.072  10.732 1.00 82.99  ? 443  LEU A CB    1 ? 
ATOM   3434 C CG    . LEU A 1 441 ? 12.825  11.886  11.997 1.00 86.33  ? 443  LEU A CG    1 ? 
ATOM   3435 C CD1   . LEU A 1 441 ? 12.154  11.207  13.180 1.00 81.81  ? 443  LEU A CD1   1 ? 
ATOM   3436 C CD2   . LEU A 1 441 ? 14.322  12.055  12.243 1.00 80.10  ? 443  LEU A CD2   1 ? 
ATOM   3437 N N     . VAL A 1 442 ? 12.261  10.188  7.670  1.00 84.14  ? 444  VAL A N     1 ? 
ATOM   3438 C CA    . VAL A 1 442 ? 12.632  9.260   6.564  1.00 91.35  ? 444  VAL A CA    1 ? 
ATOM   3439 C C     . VAL A 1 442 ? 13.092  10.084  5.355  1.00 89.55  ? 444  VAL A C     1 ? 
ATOM   3440 O O     . VAL A 1 442 ? 14.040  9.632   4.676  1.00 87.82  ? 444  VAL A O     1 ? 
ATOM   3441 C CB    . VAL A 1 442 ? 11.472  8.311   6.218  1.00 86.68  ? 444  VAL A CB    1 ? 
ATOM   3442 C CG1   . VAL A 1 442 ? 11.592  7.764   4.812  1.00 85.10  ? 444  VAL A CG1   1 ? 
ATOM   3443 C CG2   . VAL A 1 442 ? 11.385  7.178   7.224  1.00 82.03  ? 444  VAL A CG2   1 ? 
ATOM   3444 N N     . ALA A 1 443 ? 12.507  11.258  5.140  1.00 88.43  ? 445  ALA A N     1 ? 
ATOM   3445 C CA    . ALA A 1 443 ? 12.928  12.134  4.026  1.00 92.68  ? 445  ALA A CA    1 ? 
ATOM   3446 C C     . ALA A 1 443 ? 14.411  12.502  4.168  1.00 98.79  ? 445  ALA A C     1 ? 
ATOM   3447 O O     . ALA A 1 443 ? 15.061  12.687  3.128  1.00 96.37  ? 445  ALA A O     1 ? 
ATOM   3448 C CB    . ALA A 1 443 ? 12.040  13.350  3.993  1.00 86.58  ? 445  ALA A CB    1 ? 
ATOM   3449 N N     . GLN A 1 444 ? 14.926  12.580  5.401  1.00 101.90 ? 446  GLN A N     1 ? 
ATOM   3450 C CA    . GLN A 1 444 ? 16.354  12.909  5.651  1.00 96.18  ? 446  GLN A CA    1 ? 
ATOM   3451 C C     . GLN A 1 444 ? 17.199  11.635  5.756  1.00 101.81 ? 446  GLN A C     1 ? 
ATOM   3452 O O     . GLN A 1 444 ? 18.383  11.755  6.102  1.00 108.38 ? 446  GLN A O     1 ? 
ATOM   3453 C CB    . GLN A 1 444 ? 16.504  13.652  6.972  1.00 96.20  ? 446  GLN A CB    1 ? 
ATOM   3454 C CG    . GLN A 1 444 ? 15.475  14.744  7.199  1.00 106.19 ? 446  GLN A CG    1 ? 
ATOM   3455 C CD    . GLN A 1 444 ? 15.523  15.220  8.629  1.00 116.37 ? 446  GLN A CD    1 ? 
ATOM   3456 O OE1   . GLN A 1 444 ? 16.298  14.723  9.444  1.00 104.44 ? 446  GLN A OE1   1 ? 
ATOM   3457 N NE2   . GLN A 1 444 ? 14.683  16.191  8.947  1.00 114.90 ? 446  GLN A NE2   1 ? 
ATOM   3458 N N     . GLY A 1 445 ? 16.611  10.463  5.509  1.00 91.72  ? 447  GLY A N     1 ? 
ATOM   3459 C CA    . GLY A 1 445 ? 17.347  9.190   5.612  1.00 88.35  ? 447  GLY A CA    1 ? 
ATOM   3460 C C     . GLY A 1 445 ? 17.596  8.800   7.055  1.00 89.50  ? 447  GLY A C     1 ? 
ATOM   3461 O O     . GLY A 1 445 ? 18.686  8.278   7.341  1.00 95.57  ? 447  GLY A O     1 ? 
ATOM   3462 N N     . ASN A 1 446 ? 16.622  9.043   7.929  1.00 91.74  ? 448  ASN A N     1 ? 
ATOM   3463 C CA    . ASN A 1 446 ? 16.743  8.719   9.372  1.00 91.62  ? 448  ASN A CA    1 ? 
ATOM   3464 C C     . ASN A 1 446 ? 15.730  7.638   9.753  1.00 85.55  ? 448  ASN A C     1 ? 
ATOM   3465 O O     . ASN A 1 446 ? 14.888  7.258   8.904  1.00 83.63  ? 448  ASN A O     1 ? 
ATOM   3466 C CB    . ASN A 1 446 ? 16.564  9.963   10.238 1.00 93.00  ? 448  ASN A CB    1 ? 
ATOM   3467 C CG    . ASN A 1 446 ? 17.822  10.801  10.346 1.00 100.32 ? 448  ASN A CG    1 ? 
ATOM   3468 O OD1   . ASN A 1 446 ? 17.798  12.005  10.075 1.00 100.43 ? 448  ASN A OD1   1 ? 
ATOM   3469 N ND2   . ASN A 1 446 ? 18.916  10.179  10.766 1.00 95.18  ? 448  ASN A ND2   1 ? 
ATOM   3470 N N     . GLY A 1 447 ? 15.838  7.157   10.990 1.00 80.30  ? 449  GLY A N     1 ? 
ATOM   3471 C CA    . GLY A 1 447 ? 14.942  6.122   11.535 1.00 79.64  ? 449  GLY A CA    1 ? 
ATOM   3472 C C     . GLY A 1 447 ? 13.573  6.693   11.858 1.00 73.60  ? 449  GLY A C     1 ? 
ATOM   3473 O O     . GLY A 1 447 ? 13.475  7.807   12.415 1.00 72.91  ? 449  GLY A O     1 ? 
ATOM   3474 N N     . ALA A 1 448 ? 12.527  5.955   11.525 1.00 71.12  ? 450  ALA A N     1 ? 
ATOM   3475 C CA    . ALA A 1 448 ? 11.139  6.422   11.725 1.00 68.85  ? 450  ALA A CA    1 ? 
ATOM   3476 C C     . ALA A 1 448 ? 10.778  6.334   13.211 1.00 72.46  ? 450  ALA A C     1 ? 
ATOM   3477 O O     . ALA A 1 448 ? 10.281  7.347   13.778 1.00 68.64  ? 450  ALA A O     1 ? 
ATOM   3478 C CB    . ALA A 1 448 ? 10.202  5.604   10.886 1.00 65.48  ? 450  ALA A CB    1 ? 
ATOM   3479 N N     . TYR A 1 449 ? 11.021  5.168   13.819 1.00 66.13  ? 451  TYR A N     1 ? 
ATOM   3480 C CA    . TYR A 1 449 ? 10.701  4.890   15.249 1.00 63.66  ? 451  TYR A CA    1 ? 
ATOM   3481 C C     . TYR A 1 449 ? 9.258   5.269   15.555 1.00 50.75  ? 451  TYR A C     1 ? 
ATOM   3482 O O     . TYR A 1 449 ? 8.985   5.975   16.503 1.00 50.02  ? 451  TYR A O     1 ? 
ATOM   3483 C CB    . TYR A 1 449 ? 11.674  5.618   16.176 1.00 67.37  ? 451  TYR A CB    1 ? 
ATOM   3484 C CG    . TYR A 1 449 ? 13.083  5.105   16.061 1.00 67.01  ? 451  TYR A CG    1 ? 
ATOM   3485 C CD1   . TYR A 1 449 ? 13.326  3.745   15.943 1.00 69.24  ? 451  TYR A CD1   1 ? 
ATOM   3486 C CD2   . TYR A 1 449 ? 14.164  5.974   16.005 1.00 68.56  ? 451  TYR A CD2   1 ? 
ATOM   3487 C CE1   . TYR A 1 449 ? 14.611  3.251   15.801 1.00 69.11  ? 451  TYR A CE1   1 ? 
ATOM   3488 C CE2   . TYR A 1 449 ? 15.460  5.498   15.862 1.00 70.08  ? 451  TYR A CE2   1 ? 
ATOM   3489 C CZ    . TYR A 1 449 ? 15.681  4.132   15.761 1.00 73.44  ? 451  TYR A CZ    1 ? 
ATOM   3490 O OH    . TYR A 1 449 ? 16.949  3.654   15.623 1.00 75.41  ? 451  TYR A OH    1 ? 
ATOM   3491 N N     . CYS A 1 450 ? 8.358   4.783   14.726 1.00 56.14  ? 452  CYS A N     1 ? 
ATOM   3492 C CA    . CYS A 1 450 ? 6.904   5.012   14.843 1.00 53.11  ? 452  CYS A CA    1 ? 
ATOM   3493 C C     . CYS A 1 450 ? 6.201   3.702   15.208 1.00 47.44  ? 452  CYS A C     1 ? 
ATOM   3494 O O     . CYS A 1 450 ? 6.850   2.691   15.336 1.00 62.60  ? 452  CYS A O     1 ? 
ATOM   3495 C CB    . CYS A 1 450 ? 6.351   5.628   13.558 1.00 54.52  ? 452  CYS A CB    1 ? 
ATOM   3496 S SG    . CYS A 1 450 ? 6.521   4.634   12.076 1.00 60.35  ? 452  CYS A SG    1 ? 
ATOM   3497 N N     . ALA A 1 451 ? 4.892   3.742   15.332 1.00 49.56  ? 453  ALA A N     1 ? 
ATOM   3498 C CA    . ALA A 1 451 ? 4.072   2.556   15.653 1.00 53.91  ? 453  ALA A CA    1 ? 
ATOM   3499 C C     . ALA A 1 451 ? 4.151   1.483   14.560 1.00 54.67  ? 453  ALA A C     1 ? 
ATOM   3500 O O     . ALA A 1 451 ? 4.198   0.299   14.904 1.00 61.69  ? 453  ALA A O     1 ? 
ATOM   3501 C CB    . ALA A 1 451 ? 2.649   2.968   15.883 1.00 48.23  ? 453  ALA A CB    1 ? 
ATOM   3502 N N     . ALA A 1 452 ? 4.160   1.885   13.285 1.00 54.93  ? 454  ALA A N     1 ? 
ATOM   3503 C CA    . ALA A 1 452 ? 4.252   0.928   12.159 1.00 54.07  ? 454  ALA A CA    1 ? 
ATOM   3504 C C     . ALA A 1 452 ? 5.612   0.240   12.118 1.00 47.46  ? 454  ALA A C     1 ? 
ATOM   3505 O O     . ALA A 1 452 ? 5.655   -0.968  11.941 1.00 51.98  ? 454  ALA A O     1 ? 
ATOM   3506 C CB    . ALA A 1 452 ? 3.992   1.641   10.871 1.00 58.17  ? 454  ALA A CB    1 ? 
ATOM   3507 N N     . THR A 1 453 ? 6.676   0.995   12.325 1.00 48.00  ? 455  THR A N     1 ? 
ATOM   3508 C CA    . THR A 1 453 ? 8.041   0.411   12.365 1.00 54.49  ? 455  THR A CA    1 ? 
ATOM   3509 C C     . THR A 1 453 ? 8.223   -0.467  13.604 1.00 48.75  ? 455  THR A C     1 ? 
ATOM   3510 O O     . THR A 1 453 ? 8.912   -1.468  13.491 1.00 55.98  ? 455  THR A O     1 ? 
ATOM   3511 C CB    . THR A 1 453 ? 9.112   1.509   12.296 1.00 53.68  ? 455  THR A CB    1 ? 
ATOM   3512 O OG1   . THR A 1 453 ? 8.861   2.579   13.202 1.00 60.04  ? 455  THR A OG1   1 ? 
ATOM   3513 C CG2   . THR A 1 453 ? 9.170   2.074   10.903 1.00 51.34  ? 455  THR A CG2   1 ? 
ATOM   3514 N N     . GLY A 1 454 ? 7.648   -0.076  14.747 1.00 46.78  ? 456  GLY A N     1 ? 
ATOM   3515 C CA    . GLY A 1 454 ? 7.722   -0.873  15.988 1.00 46.98  ? 456  GLY A CA    1 ? 
ATOM   3516 C C     . GLY A 1 454 ? 7.049   -2.229  15.832 1.00 45.94  ? 456  GLY A C     1 ? 
ATOM   3517 O O     . GLY A 1 454 ? 7.678   -3.246  16.147 1.00 48.37  ? 456  GLY A O     1 ? 
ATOM   3518 N N     . GLU A 1 455 ? 5.847   -2.248  15.279 1.00 41.48  ? 457  GLU A N     1 ? 
ATOM   3519 C CA    . GLU A 1 455 ? 5.119   -3.514  15.053 1.00 45.89  ? 457  GLU A CA    1 ? 
ATOM   3520 C C     . GLU A 1 455 ? 5.855   -4.361  14.019 1.00 45.41  ? 457  GLU A C     1 ? 
ATOM   3521 O O     . GLU A 1 455 ? 6.003   -5.553  14.255 1.00 54.35  ? 457  GLU A O     1 ? 
ATOM   3522 C CB    . GLU A 1 455 ? 3.681   -3.196  14.654 1.00 44.72  ? 457  GLU A CB    1 ? 
ATOM   3523 C CG    . GLU A 1 455 ? 2.849   -4.416  14.262 1.00 50.83  ? 457  GLU A CG    1 ? 
ATOM   3524 C CD    . GLU A 1 455 ? 1.359   -4.171  14.257 1.00 44.23  ? 457  GLU A CD    1 ? 
ATOM   3525 O OE1   . GLU A 1 455 ? 0.958   -3.030  14.346 1.00 51.36  ? 457  GLU A OE1   1 ? 
ATOM   3526 O OE2   . GLU A 1 455 ? 0.613   -5.131  14.110 1.00 45.44  ? 457  GLU A OE2   1 ? 
ATOM   3527 N N     . ALA A 1 456 ? 6.298   -3.769  12.911 1.00 49.07  ? 458  ALA A N     1 ? 
ATOM   3528 C CA    . ALA A 1 456 ? 7.006   -4.523  11.851 1.00 48.01  ? 458  ALA A CA    1 ? 
ATOM   3529 C C     . ALA A 1 456 ? 8.291   -5.122  12.425 1.00 41.90  ? 458  ALA A C     1 ? 
ATOM   3530 O O     . ALA A 1 456 ? 8.633   -6.257  12.124 1.00 46.50  ? 458  ALA A O     1 ? 
ATOM   3531 C CB    . ALA A 1 456 ? 7.264   -3.643  10.656 1.00 46.93  ? 458  ALA A CB    1 ? 
ATOM   3532 N N     . ALA A 1 457 ? 8.997   -4.343  13.222 1.00 45.71  ? 459  ALA A N     1 ? 
ATOM   3533 C CA    . ALA A 1 457 ? 10.276  -4.777  13.821 1.00 43.79  ? 459  ALA A CA    1 ? 
ATOM   3534 C C     . ALA A 1 457 ? 9.998   -5.931  14.794 1.00 49.60  ? 459  ALA A C     1 ? 
ATOM   3535 O O     . ALA A 1 457 ? 10.836  -6.851  14.843 1.00 55.11  ? 459  ALA A O     1 ? 
ATOM   3536 C CB    . ALA A 1 457 ? 10.946  -3.615  14.507 1.00 43.60  ? 459  ALA A CB    1 ? 
ATOM   3537 N N     . PHE A 1 458 ? 8.879   -5.900  15.522 1.00 47.52  ? 460  PHE A N     1 ? 
ATOM   3538 C CA    . PHE A 1 458 ? 8.505   -7.010  16.434 1.00 48.91  ? 460  PHE A CA    1 ? 
ATOM   3539 C C     . PHE A 1 458 ? 8.311   -8.294  15.626 1.00 44.82  ? 460  PHE A C     1 ? 
ATOM   3540 O O     . PHE A 1 458 ? 8.833   -9.326  15.972 1.00 47.60  ? 460  PHE A O     1 ? 
ATOM   3541 C CB    . PHE A 1 458 ? 7.249   -6.679  17.249 1.00 46.87  ? 460  PHE A CB    1 ? 
ATOM   3542 C CG    . PHE A 1 458 ? 6.902   -7.741  18.249 1.00 48.34  ? 460  PHE A CG    1 ? 
ATOM   3543 C CD1   . PHE A 1 458 ? 7.536   -7.804  19.477 1.00 51.69  ? 460  PHE A CD1   1 ? 
ATOM   3544 C CD2   . PHE A 1 458 ? 5.996   -8.727  17.926 1.00 52.41  ? 460  PHE A CD2   1 ? 
ATOM   3545 C CE1   . PHE A 1 458 ? 7.211   -8.792  20.393 1.00 51.48  ? 460  PHE A CE1   1 ? 
ATOM   3546 C CE2   . PHE A 1 458 ? 5.693   -9.746  18.821 1.00 49.29  ? 460  PHE A CE2   1 ? 
ATOM   3547 C CZ    . PHE A 1 458 ? 6.286   -9.769  20.056 1.00 51.42  ? 460  PHE A CZ    1 ? 
ATOM   3548 N N     . TYR A 1 459 ? 7.548   -8.212  14.539 1.00 50.46  ? 461  TYR A N     1 ? 
ATOM   3549 C CA    . TYR A 1 459 ? 7.323   -9.395  13.678 1.00 47.20  ? 461  TYR A CA    1 ? 
ATOM   3550 C C     . TYR A 1 459 ? 8.642   -9.904  13.087 1.00 48.15  ? 461  TYR A C     1 ? 
ATOM   3551 O O     . TYR A 1 459 ? 8.915   -11.124 13.114 1.00 45.71  ? 461  TYR A O     1 ? 
ATOM   3552 C CB    . TYR A 1 459 ? 6.326   -9.108  12.569 1.00 45.66  ? 461  TYR A CB    1 ? 
ATOM   3553 C CG    . TYR A 1 459 ? 4.940   -8.754  13.039 1.00 50.42  ? 461  TYR A CG    1 ? 
ATOM   3554 C CD1   . TYR A 1 459 ? 4.372   -9.378  14.144 1.00 50.73  ? 461  TYR A CD1   1 ? 
ATOM   3555 C CD2   . TYR A 1 459 ? 4.187   -7.790  12.375 1.00 50.93  ? 461  TYR A CD2   1 ? 
ATOM   3556 C CE1   . TYR A 1 459 ? 3.099   -9.046  14.576 1.00 47.37  ? 461  TYR A CE1   1 ? 
ATOM   3557 C CE2   . TYR A 1 459 ? 2.905   -7.441  12.796 1.00 50.08  ? 461  TYR A CE2   1 ? 
ATOM   3558 C CZ    . TYR A 1 459 ? 2.355   -8.066  13.920 1.00 55.01  ? 461  TYR A CZ    1 ? 
ATOM   3559 O OH    . TYR A 1 459 ? 1.099   -7.727  14.376 1.00 47.52  ? 461  TYR A OH    1 ? 
ATOM   3560 N N     . GLU A 1 460 ? 9.479   -8.989  12.619 1.00 49.84  ? 462  GLU A N     1 ? 
ATOM   3561 C CA    . GLU A 1 460 ? 10.774  -9.384  12.028 1.00 48.76  ? 462  GLU A CA    1 ? 
ATOM   3562 C C     . GLU A 1 460 ? 11.643  -10.019 13.111 1.00 46.80  ? 462  GLU A C     1 ? 
ATOM   3563 O O     . GLU A 1 460 ? 12.329  -10.979 12.777 1.00 52.98  ? 462  GLU A O     1 ? 
ATOM   3564 C CB    . GLU A 1 460 ? 11.428  -8.177  11.355 1.00 50.84  ? 462  GLU A CB    1 ? 
ATOM   3565 C CG    . GLU A 1 460 ? 12.806  -8.466  10.810 1.00 51.51  ? 462  GLU A CG    1 ? 
ATOM   3566 C CD    . GLU A 1 460 ? 12.834  -9.538  9.734  1.00 60.77  ? 462  GLU A CD    1 ? 
ATOM   3567 O OE1   . GLU A 1 460 ? 11.769  -9.872  9.164  1.00 60.93  ? 462  GLU A OE1   1 ? 
ATOM   3568 O OE2   . GLU A 1 460 ? 13.952  -10.046 9.475  1.00 69.51  ? 462  GLU A OE2   1 ? 
ATOM   3569 N N     . LEU A 1 461 ? 11.616  -9.492  14.338 1.00 53.34  ? 463  LEU A N     1 ? 
ATOM   3570 C CA    . LEU A 1 461 ? 12.425  -10.054 15.454 1.00 52.89  ? 463  LEU A CA    1 ? 
ATOM   3571 C C     . LEU A 1 461 ? 12.007  -11.500 15.710 1.00 52.94  ? 463  LEU A C     1 ? 
ATOM   3572 O O     . LEU A 1 461 ? 12.885  -12.396 15.722 1.00 58.88  ? 463  LEU A O     1 ? 
ATOM   3573 C CB    . LEU A 1 461 ? 12.247  -9.204  16.699 1.00 53.11  ? 463  LEU A CB    1 ? 
ATOM   3574 C CG    . LEU A 1 461 ? 12.808  -9.771  18.008 1.00 55.05  ? 463  LEU A CG    1 ? 
ATOM   3575 C CD1   . LEU A 1 461 ? 14.313  -9.882  17.942 1.00 63.46  ? 463  LEU A CD1   1 ? 
ATOM   3576 C CD2   . LEU A 1 461 ? 12.412  -8.887  19.177 1.00 52.69  ? 463  LEU A CD2   1 ? 
ATOM   3577 N N     . GLN A 1 462 ? 10.719  -11.758 15.810 1.00 51.99  ? 464  GLN A N     1 ? 
ATOM   3578 C CA    . GLN A 1 462 ? 10.241  -13.147 16.027 1.00 50.70  ? 464  GLN A CA    1 ? 
ATOM   3579 C C     . GLN A 1 462 ? 10.724  -14.024 14.867 1.00 56.29  ? 464  GLN A C     1 ? 
ATOM   3580 O O     . GLN A 1 462 ? 11.250  -15.114 15.143 1.00 55.14  ? 464  GLN A O     1 ? 
ATOM   3581 C CB    . GLN A 1 462 ? 8.721   -13.218 16.152 1.00 46.66  ? 464  GLN A CB    1 ? 
ATOM   3582 C CG    . GLN A 1 462 ? 8.143   -12.224 17.148 1.00 53.78  ? 464  GLN A CG    1 ? 
ATOM   3583 C CD    . GLN A 1 462 ? 8.758   -12.377 18.511 1.00 61.54  ? 464  GLN A CD    1 ? 
ATOM   3584 O OE1   . GLN A 1 462 ? 8.840   -13.478 19.056 1.00 70.30  ? 464  GLN A OE1   1 ? 
ATOM   3585 N NE2   . GLN A 1 462 ? 9.164   -11.251 19.078 1.00 61.67  ? 464  GLN A NE2   1 ? 
ATOM   3586 N N     . ARG A 1 463 ? 10.596  -13.550 13.627 1.00 59.23  ? 465  ARG A N     1 ? 
ATOM   3587 C CA    . ARG A 1 463 ? 11.019  -14.341 12.448 1.00 53.20  ? 465  ARG A CA    1 ? 
ATOM   3588 C C     . ARG A 1 463 ? 12.523  -14.623 12.509 1.00 52.63  ? 465  ARG A C     1 ? 
ATOM   3589 O O     . ARG A 1 463 ? 12.927  -15.732 12.261 1.00 51.28  ? 465  ARG A O     1 ? 
ATOM   3590 C CB    . ARG A 1 463 ? 10.670  -13.617 11.148 1.00 57.61  ? 465  ARG A CB    1 ? 
ATOM   3591 C CG    . ARG A 1 463 ? 9.189   -13.593 10.827 1.00 52.06  ? 465  ARG A CG    1 ? 
ATOM   3592 C CD    . ARG A 1 463 ? 8.962   -13.114 9.424  1.00 51.43  ? 465  ARG A CD    1 ? 
ATOM   3593 N NE    . ARG A 1 463 ? 9.279   -11.710 9.252  1.00 52.76  ? 465  ARG A NE    1 ? 
ATOM   3594 C CZ    . ARG A 1 463 ? 8.415   -10.721 9.353  1.00 49.21  ? 465  ARG A CZ    1 ? 
ATOM   3595 N NH1   . ARG A 1 463 ? 7.143   -10.957 9.621  1.00 51.49  ? 465  ARG A NH1   1 ? 
ATOM   3596 N NH2   . ARG A 1 463 ? 8.841   -9.482  9.199  1.00 54.89  ? 465  ARG A NH2   1 ? 
ATOM   3597 N N     . ARG A 1 464 ? 13.332  -13.627 12.845 1.00 58.34  ? 466  ARG A N     1 ? 
ATOM   3598 C CA    . ARG A 1 464 ? 14.801  -13.807 12.891 1.00 55.52  ? 466  ARG A CA    1 ? 
ATOM   3599 C C     . ARG A 1 464 ? 15.189  -14.773 13.991 1.00 55.28  ? 466  ARG A C     1 ? 
ATOM   3600 O O     . ARG A 1 464 ? 16.086  -15.581 13.752 1.00 59.08  ? 466  ARG A O     1 ? 
ATOM   3601 C CB    . ARG A 1 464 ? 15.505  -12.477 13.126 1.00 54.14  ? 466  ARG A CB    1 ? 
ATOM   3602 C CG    . ARG A 1 464 ? 15.505  -11.570 11.911 1.00 57.75  ? 466  ARG A CG    1 ? 
ATOM   3603 C CD    . ARG A 1 464 ? 16.289  -10.307 12.220 1.00 63.36  ? 466  ARG A CD    1 ? 
ATOM   3604 N NE    . ARG A 1 464 ? 16.269  -9.360  11.103 1.00 64.75  ? 466  ARG A NE    1 ? 
ATOM   3605 C CZ    . ARG A 1 464 ? 16.961  -8.239  11.063 1.00 58.77  ? 466  ARG A CZ    1 ? 
ATOM   3606 N NH1   . ARG A 1 464 ? 17.744  -7.884  12.066 1.00 66.60  ? 466  ARG A NH1   1 ? 
ATOM   3607 N NH2   . ARG A 1 464 ? 16.856  -7.453  10.013 1.00 63.21  ? 466  ARG A NH2   1 ? 
ATOM   3608 N N     . ARG A 1 465 ? 14.555  -14.658 15.152 1.00 58.90  ? 467  ARG A N     1 ? 
ATOM   3609 C CA    . ARG A 1 465 ? 14.846  -15.583 16.262 1.00 55.07  ? 467  ARG A CA    1 ? 
ATOM   3610 C C     . ARG A 1 465 ? 14.482  -17.009 15.835 1.00 59.76  ? 467  ARG A C     1 ? 
ATOM   3611 O O     . ARG A 1 465 ? 15.253  -17.933 16.118 1.00 58.97  ? 467  ARG A O     1 ? 
ATOM   3612 C CB    . ARG A 1 465 ? 14.129  -15.115 17.519 1.00 51.95  ? 467  ARG A CB    1 ? 
ATOM   3613 C CG    . ARG A 1 465 ? 14.715  -13.828 18.082 1.00 48.71  ? 467  ARG A CG    1 ? 
ATOM   3614 C CD    . ARG A 1 465 ? 16.058  -14.061 18.751 1.00 49.62  ? 467  ARG A CD    1 ? 
ATOM   3615 N NE    . ARG A 1 465 ? 15.898  -14.566 20.087 1.00 59.08  ? 467  ARG A NE    1 ? 
ATOM   3616 C CZ    . ARG A 1 465 ? 16.875  -14.718 20.968 1.00 59.74  ? 467  ARG A CZ    1 ? 
ATOM   3617 N NH1   . ARG A 1 465 ? 18.122  -14.461 20.620 1.00 63.29  ? 467  ARG A NH1   1 ? 
ATOM   3618 N NH2   . ARG A 1 465 ? 16.609  -15.162 22.183 1.00 56.32  ? 467  ARG A NH2   1 ? 
ATOM   3619 N N     . LEU A 1 466 ? 13.350  -17.187 15.179 1.00 57.79  ? 468  LEU A N     1 ? 
ATOM   3620 C CA    . LEU A 1 466 ? 12.893  -18.547 14.819 1.00 52.44  ? 468  LEU A CA    1 ? 
ATOM   3621 C C     . LEU A 1 466 ? 13.812  -19.114 13.752 1.00 56.58  ? 468  LEU A C     1 ? 
ATOM   3622 O O     . LEU A 1 466 ? 14.060  -20.317 13.767 1.00 59.65  ? 468  LEU A O     1 ? 
ATOM   3623 C CB    . LEU A 1 466 ? 11.440  -18.496 14.339 1.00 57.53  ? 468  LEU A CB    1 ? 
ATOM   3624 C CG    . LEU A 1 466 ? 10.425  -18.300 15.455 1.00 56.58  ? 468  LEU A CG    1 ? 
ATOM   3625 C CD1   . LEU A 1 466 ? 9.028   -18.154 14.885 1.00 64.45  ? 468  LEU A CD1   1 ? 
ATOM   3626 C CD2   . LEU A 1 466 ? 10.490  -19.468 16.411 1.00 60.34  ? 468  LEU A CD2   1 ? 
ATOM   3627 N N     . LYS A 1 467 ? 14.276  -18.285 12.829 1.00 61.88  ? 469  LYS A N     1 ? 
ATOM   3628 C CA    . LYS A 1 467 ? 15.184  -18.777 11.769 1.00 60.80  ? 469  LYS A CA    1 ? 
ATOM   3629 C C     . LYS A 1 467 ? 16.530  -19.138 12.393 1.00 59.87  ? 469  LYS A C     1 ? 
ATOM   3630 O O     . LYS A 1 467 ? 17.214  -20.018 11.857 1.00 71.06  ? 469  LYS A O     1 ? 
ATOM   3631 C CB    . LYS A 1 467 ? 15.324  -17.757 10.650 1.00 56.29  ? 469  LYS A CB    1 ? 
ATOM   3632 C CG    . LYS A 1 467 ? 14.141  -17.710 9.708  1.00 60.11  ? 469  LYS A CG    1 ? 
ATOM   3633 C CD    . LYS A 1 467 ? 14.406  -16.832 8.494  1.00 61.15  ? 469  LYS A CD    1 ? 
ATOM   3634 C CE    . LYS A 1 467 ? 14.997  -15.500 8.882  1.00 65.01  ? 469  LYS A CE    1 ? 
ATOM   3635 N NZ    . LYS A 1 467 ? 15.179  -14.614 7.708  1.00 64.42  ? 469  LYS A NZ    1 ? 
ATOM   3636 N N     . ALA A 1 468 ? 16.880  -18.513 13.505 1.00 63.08  ? 470  ALA A N     1 ? 
ATOM   3637 C CA    . ALA A 1 468 ? 18.167  -18.771 14.189 1.00 56.34  ? 470  ALA A CA    1 ? 
ATOM   3638 C C     . ALA A 1 468 ? 18.222  -20.229 14.668 1.00 65.04  ? 470  ALA A C     1 ? 
ATOM   3639 O O     . ALA A 1 468 ? 19.339  -20.776 14.788 1.00 62.78  ? 470  ALA A O     1 ? 
ATOM   3640 C CB    . ALA A 1 468 ? 18.353  -17.821 15.324 1.00 51.61  ? 470  ALA A CB    1 ? 
ATOM   3641 N N     . ILE A 1 469 ? 17.065  -20.843 14.937 1.00 62.71  ? 471  ILE A N     1 ? 
ATOM   3642 C CA    . ILE A 1 469 ? 17.013  -22.240 15.454 1.00 57.88  ? 471  ILE A CA    1 ? 
ATOM   3643 C C     . ILE A 1 469 ? 16.656  -23.186 14.308 1.00 58.28  ? 471  ILE A C     1 ? 
ATOM   3644 O O     . ILE A 1 469 ? 16.345  -24.344 14.593 1.00 61.54  ? 471  ILE A O     1 ? 
ATOM   3645 C CB    . ILE A 1 469 ? 16.022  -22.376 16.629 1.00 52.28  ? 471  ILE A CB    1 ? 
ATOM   3646 C CG1   . ILE A 1 469 ? 14.585  -22.105 16.158 1.00 61.04  ? 471  ILE A CG1   1 ? 
ATOM   3647 C CG2   . ILE A 1 469 ? 16.404  -21.471 17.773 1.00 54.32  ? 471  ILE A CG2   1 ? 
ATOM   3648 C CD1   . ILE A 1 469 ? 13.520  -22.752 17.022 1.00 65.38  ? 471  ILE A CD1   1 ? 
ATOM   3649 N N     . GLY A 1 470 ? 16.665  -22.701 13.065 1.00 58.26  ? 472  GLY A N     1 ? 
ATOM   3650 C CA    . GLY A 1 470 ? 16.525  -23.575 11.884 1.00 56.77  ? 472  GLY A CA    1 ? 
ATOM   3651 C C     . GLY A 1 470 ? 15.129  -23.645 11.304 1.00 58.11  ? 472  GLY A C     1 ? 
ATOM   3652 O O     . GLY A 1 470 ? 14.921  -24.472 10.408 1.00 64.00  ? 472  GLY A O     1 ? 
ATOM   3653 N N     . LEU A 1 471 ? 14.191  -22.816 11.748 1.00 62.14  ? 473  LEU A N     1 ? 
ATOM   3654 C CA    . LEU A 1 471 ? 12.858  -22.751 11.082 1.00 55.34  ? 473  LEU A CA    1 ? 
ATOM   3655 C C     . LEU A 1 471 ? 13.042  -22.180 9.684  1.00 51.51  ? 473  LEU A C     1 ? 
ATOM   3656 O O     . LEU A 1 471 ? 13.591  -21.106 9.518  1.00 62.49  ? 473  LEU A O     1 ? 
ATOM   3657 C CB    . LEU A 1 471 ? 11.912  -21.876 11.902 1.00 55.13  ? 473  LEU A CB    1 ? 
ATOM   3658 C CG    . LEU A 1 471 ? 10.431  -22.126 11.652 1.00 55.41  ? 473  LEU A CG    1 ? 
ATOM   3659 C CD1   . LEU A 1 471 ? 10.005  -23.458 12.232 1.00 56.02  ? 473  LEU A CD1   1 ? 
ATOM   3660 C CD2   . LEU A 1 471 ? 9.598   -21.023 12.262 1.00 62.31  ? 473  LEU A CD2   1 ? 
ATOM   3661 N N     . PRO A 1 472 ? 12.637  -22.912 8.637  1.00 55.74  ? 474  PRO A N     1 ? 
ATOM   3662 C CA    . PRO A 1 472 ? 12.828  -22.448 7.261  1.00 55.64  ? 474  PRO A CA    1 ? 
ATOM   3663 C C     . PRO A 1 472 ? 11.730  -21.491 6.804  1.00 57.46  ? 474  PRO A C     1 ? 
ATOM   3664 O O     . PRO A 1 472 ? 10.868  -21.906 6.091  1.00 71.33  ? 474  PRO A O     1 ? 
ATOM   3665 C CB    . PRO A 1 472 ? 12.794  -23.752 6.472  1.00 53.59  ? 474  PRO A CB    1 ? 
ATOM   3666 C CG    . PRO A 1 472 ? 11.823  -24.616 7.254  1.00 53.15  ? 474  PRO A CG    1 ? 
ATOM   3667 C CD    . PRO A 1 472 ? 12.049  -24.259 8.702  1.00 50.35  ? 474  PRO A CD    1 ? 
ATOM   3668 N N     . LEU A 1 473 ? 11.812  -20.243 7.249  1.00 62.46  ? 475  LEU A N     1 ? 
ATOM   3669 C CA    . LEU A 1 473 ? 10.879  -19.165 6.840  1.00 62.59  ? 475  LEU A CA    1 ? 
ATOM   3670 C C     . LEU A 1 473 ? 11.435  -18.483 5.599  1.00 62.02  ? 475  LEU A C     1 ? 
ATOM   3671 O O     . LEU A 1 473 ? 12.438  -17.770 5.689  1.00 67.00  ? 475  LEU A O     1 ? 
ATOM   3672 C CB    . LEU A 1 473 ? 10.700  -18.145 7.961  1.00 60.97  ? 475  LEU A CB    1 ? 
ATOM   3673 C CG    . LEU A 1 473 ? 10.028  -18.661 9.219  1.00 63.90  ? 475  LEU A CG    1 ? 
ATOM   3674 C CD1   . LEU A 1 473 ? 10.182  -17.632 10.330 1.00 63.28  ? 475  LEU A CD1   1 ? 
ATOM   3675 C CD2   . LEU A 1 473 ? 8.566   -18.969 8.954  1.00 62.78  ? 475  LEU A CD2   1 ? 
ATOM   3676 N N     . PHE A 1 474 ? 10.792  -18.720 4.469  1.00 65.42  ? 476  PHE A N     1 ? 
ATOM   3677 C CA    . PHE A 1 474 ? 11.123  -18.026 3.208  1.00 68.39  ? 476  PHE A CA    1 ? 
ATOM   3678 C C     . PHE A 1 474 ? 10.067  -16.952 3.000  1.00 66.22  ? 476  PHE A C     1 ? 
ATOM   3679 O O     . PHE A 1 474 ? 8.874   -17.275 2.830  1.00 61.98  ? 476  PHE A O     1 ? 
ATOM   3680 C CB    . PHE A 1 474 ? 11.196  -19.020 2.046  1.00 69.04  ? 476  PHE A CB    1 ? 
ATOM   3681 C CG    . PHE A 1 474 ? 12.199  -20.123 2.270  1.00 68.95  ? 476  PHE A CG    1 ? 
ATOM   3682 C CD1   . PHE A 1 474 ? 13.559  -19.869 2.210  1.00 73.86  ? 476  PHE A CD1   1 ? 
ATOM   3683 C CD2   . PHE A 1 474 ? 11.778  -21.403 2.571  1.00 70.52  ? 476  PHE A CD2   1 ? 
ATOM   3684 C CE1   . PHE A 1 474 ? 14.479  -20.883 2.449  1.00 82.12  ? 476  PHE A CE1   1 ? 
ATOM   3685 C CE2   . PHE A 1 474 ? 12.696  -22.420 2.793  1.00 79.27  ? 476  PHE A CE2   1 ? 
ATOM   3686 C CZ    . PHE A 1 474 ? 14.045  -22.159 2.735  1.00 78.45  ? 476  PHE A CZ    1 ? 
ATOM   3687 N N     . TYR A 1 475 ? 10.498  -15.702 3.050  1.00 62.89  ? 477  TYR A N     1 ? 
ATOM   3688 C CA    . TYR A 1 475 ? 9.591   -14.566 2.796  1.00 62.82  ? 477  TYR A CA    1 ? 
ATOM   3689 C C     . TYR A 1 475 ? 10.382  -13.462 2.129  1.00 67.10  ? 477  TYR A C     1 ? 
ATOM   3690 O O     . TYR A 1 475 ? 11.613  -13.376 2.345  1.00 71.71  ? 477  TYR A O     1 ? 
ATOM   3691 C CB    . TYR A 1 475 ? 8.959   -14.091 4.104  1.00 61.15  ? 477  TYR A CB    1 ? 
ATOM   3692 C CG    . TYR A 1 475 ? 9.947   -13.689 5.174  1.00 63.82  ? 477  TYR A CG    1 ? 
ATOM   3693 C CD1   . TYR A 1 475 ? 10.498  -14.637 6.033  1.00 56.66  ? 477  TYR A CD1   1 ? 
ATOM   3694 C CD2   . TYR A 1 475 ? 10.308  -12.355 5.342  1.00 57.09  ? 477  TYR A CD2   1 ? 
ATOM   3695 C CE1   . TYR A 1 475 ? 11.390  -14.269 7.019  1.00 53.66  ? 477  TYR A CE1   1 ? 
ATOM   3696 C CE2   . TYR A 1 475 ? 11.183  -11.975 6.344  1.00 61.76  ? 477  TYR A CE2   1 ? 
ATOM   3697 C CZ    . TYR A 1 475 ? 11.727  -12.939 7.180  1.00 60.37  ? 477  TYR A CZ    1 ? 
ATOM   3698 O OH    . TYR A 1 475 ? 12.585  -12.583 8.186  1.00 68.59  ? 477  TYR A OH    1 ? 
ATOM   3699 N N     . SER A 1 476 ? 9.664   -12.642 1.362  1.00 72.60  ? 478  SER A N     1 ? 
ATOM   3700 C CA    . SER A 1 476 ? 10.245  -11.455 0.697  1.00 66.61  ? 478  SER A CA    1 ? 
ATOM   3701 C C     . SER A 1 476 ? 10.455  -10.354 1.711  1.00 64.05  ? 478  SER A C     1 ? 
ATOM   3702 O O     . SER A 1 476 ? 9.675   -10.276 2.674  1.00 68.91  ? 478  SER A O     1 ? 
ATOM   3703 C CB    . SER A 1 476 ? 9.356   -10.975 -0.410 1.00 74.57  ? 478  SER A CB    1 ? 
ATOM   3704 O OG    . SER A 1 476 ? 9.720   -9.649  -0.784 1.00 74.09  ? 478  SER A OG    1 ? 
ATOM   3705 N N     . SER A 1 477 ? 11.441  -9.501  1.446  1.00 67.54  ? 479  SER A N     1 ? 
ATOM   3706 C CA    . SER A 1 477 ? 11.730  -8.300  2.273  1.00 64.02  ? 479  SER A CA    1 ? 
ATOM   3707 C C     . SER A 1 477 ? 10.969  -7.079  1.746  1.00 67.24  ? 479  SER A C     1 ? 
ATOM   3708 O O     . SER A 1 477 ? 11.140  -5.977  2.317  1.00 69.29  ? 479  SER A O     1 ? 
ATOM   3709 C CB    . SER A 1 477 ? 13.194  -8.014  2.301  1.00 73.70  ? 479  SER A CB    1 ? 
ATOM   3710 O OG    . SER A 1 477 ? 13.653  -7.664  0.985  1.00 74.48  ? 479  SER A OG    1 ? 
ATOM   3711 N N     . GLN A 1 478 ? 10.193  -7.236  0.677  1.00 67.06  ? 480  GLN A N     1 ? 
ATOM   3712 C CA    . GLN A 1 478 ? 9.448   -6.101  0.087  1.00 71.42  ? 480  GLN A CA    1 ? 
ATOM   3713 C C     . GLN A 1 478 ? 8.329   -5.704  1.044  1.00 73.42  ? 480  GLN A C     1 ? 
ATOM   3714 O O     . GLN A 1 478 ? 7.671   -6.559  1.604  1.00 66.01  ? 480  GLN A O     1 ? 
ATOM   3715 C CB    . GLN A 1 478 ? 8.866   -6.488  -1.277 1.00 69.32  ? 480  GLN A CB    1 ? 
ATOM   3716 C CG    . GLN A 1 478 ? 9.933   -6.740  -2.337 1.00 70.39  ? 480  GLN A CG    1 ? 
ATOM   3717 C CD    . GLN A 1 478 ? 10.543  -5.477  -2.914 1.00 72.09  ? 480  GLN A CD    1 ? 
ATOM   3718 O OE1   . GLN A 1 478 ? 10.213  -4.337  -2.557 1.00 74.24  ? 480  GLN A OE1   1 ? 
ATOM   3719 N NE2   . GLN A 1 478 ? 11.459  -5.672  -3.844 1.00 77.81  ? 480  GLN A NE2   1 ? 
ATOM   3720 N N     . PRO A 1 479 ? 8.066   -4.395  1.231  1.00 73.79  ? 481  PRO A N     1 ? 
ATOM   3721 C CA    . PRO A 1 479 ? 6.967   -3.963  2.078  1.00 67.37  ? 481  PRO A CA    1 ? 
ATOM   3722 C C     . PRO A 1 479 ? 5.618   -4.396  1.499  1.00 67.73  ? 481  PRO A C     1 ? 
ATOM   3723 O O     . PRO A 1 479 ? 5.505   -4.588  0.322  1.00 79.20  ? 481  PRO A O     1 ? 
ATOM   3724 C CB    . PRO A 1 479 ? 7.104   -2.440  2.095  1.00 74.58  ? 481  PRO A CB    1 ? 
ATOM   3725 C CG    . PRO A 1 479 ? 7.830   -2.117  0.793  1.00 74.50  ? 481  PRO A CG    1 ? 
ATOM   3726 C CD    . PRO A 1 479 ? 8.793   -3.269  0.615  1.00 76.26  ? 481  PRO A CD    1 ? 
ATOM   3727 N N     . GLU A 1 480 ? 4.635   -4.566  2.367  1.00 62.92  ? 482  GLU A N     1 ? 
ATOM   3728 C CA    . GLU A 1 480 ? 3.274   -4.971  1.967  1.00 58.38  ? 482  GLU A CA    1 ? 
ATOM   3729 C C     . GLU A 1 480 ? 2.281   -3.816  2.105  1.00 59.49  ? 482  GLU A C     1 ? 
ATOM   3730 O O     . GLU A 1 480 ? 1.130   -3.988  1.693  1.00 61.72  ? 482  GLU A O     1 ? 
ATOM   3731 C CB    . GLU A 1 480 ? 2.806   -6.128  2.844  1.00 60.27  ? 482  GLU A CB    1 ? 
ATOM   3732 C CG    . GLU A 1 480 ? 3.816   -7.258  2.938  1.00 63.76  ? 482  GLU A CG    1 ? 
ATOM   3733 C CD    . GLU A 1 480 ? 3.374   -8.329  3.910  1.00 73.01  ? 482  GLU A CD    1 ? 
ATOM   3734 O OE1   . GLU A 1 480 ? 3.507   -8.067  5.126  1.00 75.96  ? 482  GLU A OE1   1 ? 
ATOM   3735 O OE2   . GLU A 1 480 ? 2.876   -9.404  3.445  1.00 79.07  ? 482  GLU A OE2   1 ? 
ATOM   3736 N N     . VAL A 1 481 ? 2.662   -2.709  2.728  1.00 60.34  ? 483  VAL A N     1 ? 
ATOM   3737 C CA    . VAL A 1 481 ? 1.715   -1.577  2.967  1.00 57.42  ? 483  VAL A CA    1 ? 
ATOM   3738 C C     . VAL A 1 481 ? 2.549   -0.319  3.085  1.00 58.16  ? 483  VAL A C     1 ? 
ATOM   3739 O O     . VAL A 1 481 ? 3.607   -0.350  3.729  1.00 67.70  ? 483  VAL A O     1 ? 
ATOM   3740 C CB    . VAL A 1 481 ? 0.809   -1.786  4.204  1.00 58.63  ? 483  VAL A CB    1 ? 
ATOM   3741 C CG1   . VAL A 1 481 ? 1.590   -1.852  5.511  1.00 58.55  ? 483  VAL A CG1   1 ? 
ATOM   3742 C CG2   . VAL A 1 481 ? -0.245  -0.704  4.295  1.00 57.03  ? 483  VAL A CG2   1 ? 
ATOM   3743 N N     . THR A 1 482 ? 2.098   0.730   2.420  1.00 62.18  ? 484  THR A N     1 ? 
ATOM   3744 C CA    . THR A 1 482 ? 2.760   2.047   2.473  1.00 63.59  ? 484  THR A CA    1 ? 
ATOM   3745 C C     . THR A 1 482 ? 1.933   2.884   3.435  1.00 65.19  ? 484  THR A C     1 ? 
ATOM   3746 O O     . THR A 1 482 ? 0.704   2.725   3.491  1.00 71.30  ? 484  THR A O     1 ? 
ATOM   3747 C CB    . THR A 1 482 ? 2.947   2.639   1.072  1.00 60.25  ? 484  THR A CB    1 ? 
ATOM   3748 O OG1   . THR A 1 482 ? 1.682   2.757   0.421  1.00 70.12  ? 484  THR A OG1   1 ? 
ATOM   3749 C CG2   . THR A 1 482 ? 3.884   1.792   0.239  1.00 59.57  ? 484  THR A CG2   1 ? 
ATOM   3750 N N     . VAL A 1 483 ? 2.607   3.701   4.221  1.00 68.35  ? 485  VAL A N     1 ? 
ATOM   3751 C CA    . VAL A 1 483 ? 1.902   4.535   5.218  1.00 72.62  ? 485  VAL A CA    1 ? 
ATOM   3752 C C     . VAL A 1 483 ? 2.400   5.964   5.086  1.00 76.74  ? 485  VAL A C     1 ? 
ATOM   3753 O O     . VAL A 1 483 ? 3.462   6.172   4.482  1.00 78.66  ? 485  VAL A O     1 ? 
ATOM   3754 C CB    . VAL A 1 483 ? 2.117   3.994   6.644  1.00 70.03  ? 485  VAL A CB    1 ? 
ATOM   3755 C CG1   . VAL A 1 483 ? 1.525   2.601   6.783  1.00 62.95  ? 485  VAL A CG1   1 ? 
ATOM   3756 C CG2   . VAL A 1 483 ? 3.589   3.981   7.016  1.00 66.23  ? 485  VAL A CG2   1 ? 
ATOM   3757 N N     . ALA A 1 484 ? 1.631   6.884   5.666  1.00 80.37  ? 486  ALA A N     1 ? 
ATOM   3758 C CA    . ALA A 1 484 ? 1.943   8.320   5.751  1.00 76.76  ? 486  ALA A CA    1 ? 
ATOM   3759 C C     . ALA A 1 484 ? 2.087   8.871   4.342  1.00 77.40  ? 486  ALA A C     1 ? 
ATOM   3760 O O     . ALA A 1 484 ? 3.201   9.310   3.993  1.00 81.15  ? 486  ALA A O     1 ? 
ATOM   3761 C CB    . ALA A 1 484 ? 3.196   8.524   6.569  1.00 77.89  ? 486  ALA A CB    1 ? 
ATOM   3762 N N     . LYS A 1 485 ? 0.995   8.829   3.575  1.00 86.55  ? 487  LYS A N     1 ? 
ATOM   3763 C CA    . LYS A 1 485 ? 0.910   9.436   2.218  1.00 88.94  ? 487  LYS A CA    1 ? 
ATOM   3764 C C     . LYS A 1 485 ? 2.062   8.916   1.356  1.00 86.52  ? 487  LYS A C     1 ? 
ATOM   3765 O O     . LYS A 1 485 ? 2.788   9.733   0.750  1.00 83.85  ? 487  LYS A O     1 ? 
ATOM   3766 C CB    . LYS A 1 485 ? 0.957   10.962  2.321  1.00 91.04  ? 487  LYS A CB    1 ? 
ATOM   3767 C CG    . LYS A 1 485 ? -0.330  11.587  2.825  1.00 90.19  ? 487  LYS A CG    1 ? 
ATOM   3768 C CD    . LYS A 1 485 ? -1.348  11.753  1.722  1.00 93.32  ? 487  LYS A CD    1 ? 
ATOM   3769 C CE    . LYS A 1 485 ? -2.513  12.622  2.148  1.00 94.33  ? 487  LYS A CE    1 ? 
ATOM   3770 N NZ    . LYS A 1 485 ? -3.420  12.923  1.012  1.00 96.27  ? 487  LYS A NZ    1 ? 
ATOM   3771 N N     . ASP A 1 486 ? 2.229   7.596   1.342  1.00 99.31  ? 488  ASP A N     1 ? 
ATOM   3772 C CA    . ASP A 1 486 ? 3.204   6.886   0.472  1.00 96.28  ? 488  ASP A CA    1 ? 
ATOM   3773 C C     . ASP A 1 486 ? 4.616   7.427   0.736  1.00 93.37  ? 488  ASP A C     1 ? 
ATOM   3774 O O     . ASP A 1 486 ? 5.378   7.609   -0.236 1.00 104.71 ? 488  ASP A O     1 ? 
ATOM   3775 C CB    . ASP A 1 486 ? 2.801   7.018   -1.001 0.30 95.30  ? 488  ASP A CB    1 ? 
ATOM   3776 C CG    . ASP A 1 486 ? 1.573   6.192   -1.394 0.30 110.70 ? 488  ASP A CG    1 ? 
ATOM   3777 O OD1   . ASP A 1 486 ? 1.042   5.436   -0.522 0.30 109.88 ? 488  ASP A OD1   1 ? 
ATOM   3778 O OD2   . ASP A 1 486 ? 1.146   6.292   -2.582 0.30 107.38 ? 488  ASP A OD2   1 ? 
ATOM   3779 N N     . ALA A 1 487 ? 4.960   7.683   1.997  1.00 76.17  ? 489  ALA A N     1 ? 
ATOM   3780 C CA    . ALA A 1 487 ? 6.315   8.140   2.368  1.00 71.55  ? 489  ALA A CA    1 ? 
ATOM   3781 C C     . ALA A 1 487 ? 7.240   6.924   2.505  1.00 70.65  ? 489  ALA A C     1 ? 
ATOM   3782 O O     . ALA A 1 487 ? 8.390   6.980   2.034  1.00 68.16  ? 489  ALA A O     1 ? 
ATOM   3783 C CB    . ALA A 1 487 ? 6.262   8.941   3.640  1.00 73.99  ? 489  ALA A CB    1 ? 
ATOM   3784 N N     . PHE A 1 488 ? 6.780   5.878   3.181  1.00 64.50  ? 490  PHE A N     1 ? 
ATOM   3785 C CA    . PHE A 1 488 ? 7.590   4.653   3.371  1.00 63.24  ? 490  PHE A CA    1 ? 
ATOM   3786 C C     . PHE A 1 488 ? 6.654   3.474   3.556  1.00 60.23  ? 490  PHE A C     1 ? 
ATOM   3787 O O     . PHE A 1 488 ? 5.457   3.639   3.831  1.00 63.52  ? 490  PHE A O     1 ? 
ATOM   3788 C CB    . PHE A 1 488 ? 8.579   4.788   4.527  1.00 70.61  ? 490  PHE A CB    1 ? 
ATOM   3789 C CG    . PHE A 1 488 ? 7.935   4.953   5.877  1.00 69.97  ? 490  PHE A CG    1 ? 
ATOM   3790 C CD1   . PHE A 1 488 ? 7.606   6.212   6.350  1.00 70.31  ? 490  PHE A CD1   1 ? 
ATOM   3791 C CD2   . PHE A 1 488 ? 7.663   3.848   6.672  1.00 70.49  ? 490  PHE A CD2   1 ? 
ATOM   3792 C CE1   . PHE A 1 488 ? 7.011   6.367   7.594  1.00 77.80  ? 490  PHE A CE1   1 ? 
ATOM   3793 C CE2   . PHE A 1 488 ? 7.059   4.004   7.913  1.00 72.96  ? 490  PHE A CE2   1 ? 
ATOM   3794 C CZ    . PHE A 1 488 ? 6.737   5.260   8.376  1.00 71.29  ? 490  PHE A CZ    1 ? 
ATOM   3795 N N     . GLY A 1 489 ? 7.210   2.296   3.346  1.00 63.23  ? 491  GLY A N     1 ? 
ATOM   3796 C CA    . GLY A 1 489 ? 6.459   1.042   3.458  1.00 63.22  ? 491  GLY A CA    1 ? 
ATOM   3797 C C     . GLY A 1 489 ? 7.013   0.162   4.561  1.00 62.24  ? 491  GLY A C     1 ? 
ATOM   3798 O O     . GLY A 1 489 ? 8.198   0.298   4.939  1.00 59.18  ? 491  GLY A O     1 ? 
ATOM   3799 N N     . VAL A 1 490 ? 6.161   -0.709  5.084  1.00 59.47  ? 492  VAL A N     1 ? 
ATOM   3800 C CA    . VAL A 1 490 ? 6.583   -1.751  6.054  1.00 56.35  ? 492  VAL A CA    1 ? 
ATOM   3801 C C     . VAL A 1 490 ? 5.979   -3.052  5.604  1.00 53.66  ? 492  VAL A C     1 ? 
ATOM   3802 O O     . VAL A 1 490 ? 4.977   -3.054  4.903  1.00 68.71  ? 492  VAL A O     1 ? 
ATOM   3803 C CB    . VAL A 1 490 ? 6.155   -1.435  7.498  1.00 60.61  ? 492  VAL A CB    1 ? 
ATOM   3804 C CG1   . VAL A 1 490 ? 6.672   -0.073  7.956  1.00 63.18  ? 492  VAL A CG1   1 ? 
ATOM   3805 C CG2   . VAL A 1 490 ? 4.649   -1.500  7.654  1.00 63.49  ? 492  VAL A CG2   1 ? 
ATOM   3806 N N     . ARG A 1 491 ? 6.575   -4.134  6.050  1.00 61.03  ? 493  ARG A N     1 ? 
ATOM   3807 C CA    . ARG A 1 491 ? 5.980   -5.464  5.871  1.00 59.67  ? 493  ARG A CA    1 ? 
ATOM   3808 C C     . ARG A 1 491 ? 5.731   -6.068  7.239  1.00 55.25  ? 493  ARG A C     1 ? 
ATOM   3809 O O     . ARG A 1 491 ? 6.456   -5.726  8.172  1.00 63.45  ? 493  ARG A O     1 ? 
ATOM   3810 C CB    . ARG A 1 491 ? 6.898   -6.324  5.014  1.00 62.79  ? 493  ARG A CB    1 ? 
ATOM   3811 C CG    . ARG A 1 491 ? 7.904   -7.152  5.780  1.00 58.04  ? 493  ARG A CG    1 ? 
ATOM   3812 C CD    . ARG A 1 491 ? 8.365   -8.315  4.913  1.00 58.96  ? 493  ARG A CD    1 ? 
ATOM   3813 N NE    . ARG A 1 491 ? 7.296   -9.279  4.623  1.00 57.68  ? 493  ARG A NE    1 ? 
ATOM   3814 C CZ    . ARG A 1 491 ? 6.788   -9.541  3.416  1.00 64.00  ? 493  ARG A CZ    1 ? 
ATOM   3815 N NH1   . ARG A 1 491 ? 7.241   -8.916  2.345  1.00 70.81  ? 493  ARG A NH1   1 ? 
ATOM   3816 N NH2   . ARG A 1 491 ? 5.836   -10.452 3.277  1.00 61.81  ? 493  ARG A NH2   1 ? 
ATOM   3817 N N     . LEU A 1 492 ? 4.723   -6.919  7.311  1.00 61.97  ? 494  LEU A N     1 ? 
ATOM   3818 C CA    . LEU A 1 492 ? 4.300   -7.537  8.589  1.00 59.15  ? 494  LEU A CA    1 ? 
ATOM   3819 C C     . LEU A 1 492 ? 4.393   -9.060  8.509  1.00 54.51  ? 494  LEU A C     1 ? 
ATOM   3820 O O     . LEU A 1 492 ? 4.748   -9.651  9.482  1.00 52.02  ? 494  LEU A O     1 ? 
ATOM   3821 C CB    . LEU A 1 492 ? 2.872   -7.098  8.894  1.00 49.52  ? 494  LEU A CB    1 ? 
ATOM   3822 C CG    . LEU A 1 492 ? 2.642   -5.596  8.989  1.00 52.42  ? 494  LEU A CG    1 ? 
ATOM   3823 C CD1   . LEU A 1 492 ? 1.165   -5.307  9.259  1.00 57.13  ? 494  LEU A CD1   1 ? 
ATOM   3824 C CD2   . LEU A 1 492 ? 3.497   -4.982  10.072 1.00 54.93  ? 494  LEU A CD2   1 ? 
ATOM   3825 N N     . PHE A 1 493 ? 4.032   -9.638  7.375  1.00 53.73  ? 495  PHE A N     1 ? 
ATOM   3826 C CA    . PHE A 1 493 ? 3.870   -11.092 7.241  1.00 55.16  ? 495  PHE A CA    1 ? 
ATOM   3827 C C     . PHE A 1 493 ? 5.197   -11.730 6.873  1.00 57.28  ? 495  PHE A C     1 ? 
ATOM   3828 O O     . PHE A 1 493 ? 6.035   -11.092 6.244  1.00 61.47  ? 495  PHE A O     1 ? 
ATOM   3829 C CB    . PHE A 1 493 ? 2.787   -11.394 6.224  1.00 52.33  ? 495  PHE A CB    1 ? 
ATOM   3830 C CG    . PHE A 1 493 ? 1.423   -10.979 6.692  1.00 58.75  ? 495  PHE A CG    1 ? 
ATOM   3831 C CD1   . PHE A 1 493 ? 0.964   -9.693  6.449  1.00 59.39  ? 495  PHE A CD1   1 ? 
ATOM   3832 C CD2   . PHE A 1 493 ? 0.608   -11.867 7.376  1.00 54.38  ? 495  PHE A CD2   1 ? 
ATOM   3833 C CE1   . PHE A 1 493 ? -0.299  -9.316  6.867  1.00 59.52  ? 495  PHE A CE1   1 ? 
ATOM   3834 C CE2   . PHE A 1 493 ? -0.658  -11.490 7.784  1.00 55.53  ? 495  PHE A CE2   1 ? 
ATOM   3835 C CZ    . PHE A 1 493 ? -1.100  -10.212 7.547  1.00 58.51  ? 495  PHE A CZ    1 ? 
ATOM   3836 N N     . PRO A 1 494 ? 5.440   -12.997 7.251  1.00 52.34  ? 496  PRO A N     1 ? 
ATOM   3837 C CA    . PRO A 1 494 ? 4.535   -13.799 8.076  1.00 57.34  ? 496  PRO A CA    1 ? 
ATOM   3838 C C     . PRO A 1 494 ? 4.539   -13.388 9.552  1.00 51.89  ? 496  PRO A C     1 ? 
ATOM   3839 O O     . PRO A 1 494 ? 5.571   -13.104 10.093 1.00 50.00  ? 496  PRO A O     1 ? 
ATOM   3840 C CB    . PRO A 1 494 ? 5.072   -15.235 7.881  1.00 50.95  ? 496  PRO A CB    1 ? 
ATOM   3841 C CG    . PRO A 1 494 ? 6.545   -15.015 7.678  1.00 50.36  ? 496  PRO A CG    1 ? 
ATOM   3842 C CD    . PRO A 1 494 ? 6.617   -13.752 6.833  1.00 52.09  ? 496  PRO A CD    1 ? 
ATOM   3843 N N     . ILE A 1 495 ? 3.361   -13.383 10.162 1.00 54.39  ? 497  ILE A N     1 ? 
ATOM   3844 C CA    . ILE A 1 495 ? 3.204   -13.029 11.600 1.00 54.55  ? 497  ILE A CA    1 ? 
ATOM   3845 C C     . ILE A 1 495 ? 3.262   -14.304 12.432 1.00 50.54  ? 497  ILE A C     1 ? 
ATOM   3846 O O     . ILE A 1 495 ? 2.473   -15.220 12.172 1.00 50.65  ? 497  ILE A O     1 ? 
ATOM   3847 C CB    . ILE A 1 495 ? 1.907   -12.263 11.825 1.00 50.01  ? 497  ILE A CB    1 ? 
ATOM   3848 C CG1   . ILE A 1 495 ? 1.950   -10.935 11.079 1.00 48.17  ? 497  ILE A CG1   1 ? 
ATOM   3849 C CG2   . ILE A 1 495 ? 1.680   -12.075 13.312 1.00 48.28  ? 497  ILE A CG2   1 ? 
ATOM   3850 C CD1   . ILE A 1 495 ? 0.636   -10.176 11.092 1.00 47.81  ? 497  ILE A CD1   1 ? 
ATOM   3851 N N     . ILE A 1 496 ? 4.209   -14.364 13.358 1.00 50.13  ? 498  ILE A N     1 ? 
ATOM   3852 C CA    . ILE A 1 496 ? 4.358   -15.510 14.291 1.00 48.66  ? 498  ILE A CA    1 ? 
ATOM   3853 C C     . ILE A 1 496 ? 4.512   -14.954 15.696 1.00 46.85  ? 498  ILE A C     1 ? 
ATOM   3854 O O     . ILE A 1 496 ? 5.560   -14.328 15.980 1.00 41.66  ? 498  ILE A O     1 ? 
ATOM   3855 C CB    . ILE A 1 496 ? 5.536   -16.406 13.923 1.00 45.71  ? 498  ILE A CB    1 ? 
ATOM   3856 C CG1   . ILE A 1 496 ? 5.510   -16.754 12.438 1.00 46.09  ? 498  ILE A CG1   1 ? 
ATOM   3857 C CG2   . ILE A 1 496 ? 5.491   -17.646 14.756 1.00 54.69  ? 498  ILE A CG2   1 ? 
ATOM   3858 C CD1   . ILE A 1 496 ? 6.699   -17.523 11.983 1.00 44.57  ? 498  ILE A CD1   1 ? 
ATOM   3859 N N     . VAL A 1 497 ? 3.471   -15.116 16.506 1.00 45.28  ? 499  VAL A N     1 ? 
ATOM   3860 C CA    . VAL A 1 497 ? 3.458   -14.596 17.900 1.00 46.13  ? 499  VAL A CA    1 ? 
ATOM   3861 C C     . VAL A 1 497 ? 3.257   -15.750 18.880 1.00 45.10  ? 499  VAL A C     1 ? 
ATOM   3862 O O     . VAL A 1 497 ? 2.211   -16.404 18.833 1.00 53.67  ? 499  VAL A O     1 ? 
ATOM   3863 C CB    . VAL A 1 497 ? 2.383   -13.529 18.094 1.00 50.47  ? 499  VAL A CB    1 ? 
ATOM   3864 C CG1   . VAL A 1 497 ? 2.477   -12.948 19.503 1.00 53.12  ? 499  VAL A CG1   1 ? 
ATOM   3865 C CG2   . VAL A 1 497 ? 2.485   -12.431 17.052 1.00 52.91  ? 499  VAL A CG2   1 ? 
ATOM   3866 N N     . LEU A 1 498 ? 4.272   -15.981 19.705 1.00 47.66  ? 500  LEU A N     1 ? 
ATOM   3867 C CA    . LEU A 1 498 ? 4.238   -16.996 20.776 1.00 50.86  ? 500  LEU A CA    1 ? 
ATOM   3868 C C     . LEU A 1 498 ? 4.129   -16.280 22.110 1.00 45.34  ? 500  LEU A C     1 ? 
ATOM   3869 O O     . LEU A 1 498 ? 4.836   -15.318 22.311 1.00 63.48  ? 500  LEU A O     1 ? 
ATOM   3870 C CB    . LEU A 1 498 ? 5.483   -17.876 20.738 1.00 48.53  ? 500  LEU A CB    1 ? 
ATOM   3871 C CG    . LEU A 1 498 ? 6.012   -18.244 19.369 1.00 53.12  ? 500  LEU A CG    1 ? 
ATOM   3872 C CD1   . LEU A 1 498 ? 7.325   -18.961 19.501 1.00 55.84  ? 500  LEU A CD1   1 ? 
ATOM   3873 C CD2   . LEU A 1 498 ? 5.023   -19.116 18.637 1.00 55.89  ? 500  LEU A CD2   1 ? 
ATOM   3874 N N     . ASP A 1 499 ? 3.279   -16.786 22.985 1.00 50.84  ? 501  ASP A N     1 ? 
ATOM   3875 C CA    . ASP A 1 499 ? 3.075   -16.165 24.315 1.00 56.93  ? 501  ASP A CA    1 ? 
ATOM   3876 C C     . ASP A 1 499 ? 4.154   -16.667 25.268 1.00 46.41  ? 501  ASP A C     1 ? 
ATOM   3877 O O     . ASP A 1 499 ? 4.952   -17.503 24.887 1.00 46.15  ? 501  ASP A O     1 ? 
ATOM   3878 C CB    . ASP A 1 499 ? 1.655   -16.415 24.816 1.00 60.46  ? 501  ASP A CB    1 ? 
ATOM   3879 C CG    . ASP A 1 499 ? 1.413   -17.806 25.400 1.00 64.64  ? 501  ASP A CG    1 ? 
ATOM   3880 O OD1   . ASP A 1 499 ? 2.122   -18.787 25.044 1.00 69.34  ? 501  ASP A OD1   1 ? 
ATOM   3881 O OD2   . ASP A 1 499 ? 0.523   -17.889 26.230 1.00 62.13  ? 501  ASP A OD2   1 ? 
ATOM   3882 N N     . THR A 1 500 ? 4.180   -16.119 26.468 1.00 52.28  ? 502  THR A N     1 ? 
ATOM   3883 C CA    . THR A 1 500 ? 5.260   -16.409 27.449 1.00 53.14  ? 502  THR A CA    1 ? 
ATOM   3884 C C     . THR A 1 500 ? 5.146   -17.826 27.999 1.00 57.19  ? 502  THR A C     1 ? 
ATOM   3885 O O     . THR A 1 500 ? 6.159   -18.374 28.419 1.00 57.77  ? 502  THR A O     1 ? 
ATOM   3886 C CB    . THR A 1 500 ? 5.268   -15.402 28.590 1.00 55.99  ? 502  THR A CB    1 ? 
ATOM   3887 O OG1   . THR A 1 500 ? 3.945   -15.300 29.122 1.00 62.75  ? 502  THR A OG1   1 ? 
ATOM   3888 C CG2   . THR A 1 500 ? 5.770   -14.059 28.108 1.00 53.82  ? 502  THR A CG2   1 ? 
ATOM   3889 N N     . VAL A 1 501 ? 3.963   -18.418 27.964 1.00 62.59  ? 503  VAL A N     1 ? 
ATOM   3890 C CA    . VAL A 1 501 ? 3.810   -19.840 28.367 1.00 57.72  ? 503  VAL A CA    1 ? 
ATOM   3891 C C     . VAL A 1 501 ? 4.475   -20.708 27.303 1.00 60.47  ? 503  VAL A C     1 ? 
ATOM   3892 O O     . VAL A 1 501 ? 5.130   -21.674 27.696 1.00 65.19  ? 503  VAL A O     1 ? 
ATOM   3893 C CB    . VAL A 1 501 ? 2.330   -20.195 28.580 1.00 62.53  ? 503  VAL A CB    1 ? 
ATOM   3894 C CG1   . VAL A 1 501 ? 2.185   -21.593 29.114 1.00 65.55  ? 503  VAL A CG1   1 ? 
ATOM   3895 C CG2   . VAL A 1 501 ? 1.642   -19.207 29.491 1.00 58.36  ? 503  VAL A CG2   1 ? 
ATOM   3896 N N     . CYS A 1 502 ? 4.315   -20.383 26.018 1.00 56.55  ? 504  CYS A N     1 ? 
ATOM   3897 C CA    . CYS A 1 502 ? 4.868   -21.199 24.911 1.00 50.22  ? 504  CYS A CA    1 ? 
ATOM   3898 C C     . CYS A 1 502 ? 6.368   -20.988 24.796 1.00 49.86  ? 504  CYS A C     1 ? 
ATOM   3899 O O     . CYS A 1 502 ? 7.082   -21.984 24.762 1.00 55.38  ? 504  CYS A O     1 ? 
ATOM   3900 C CB    . CYS A 1 502 ? 4.189   -20.871 23.589 1.00 48.42  ? 504  CYS A CB    1 ? 
ATOM   3901 S SG    . CYS A 1 502 ? 4.922   -21.632 22.127 1.00 58.91  ? 504  CYS A SG    1 ? 
ATOM   3902 N N     . ALA A 1 503 ? 6.800   -19.729 24.680 1.00 52.30  ? 505  ALA A N     1 ? 
ATOM   3903 C CA    . ALA A 1 503 ? 8.209   -19.378 24.354 1.00 57.20  ? 505  ALA A CA    1 ? 
ATOM   3904 C C     . ALA A 1 503 ? 9.050   -19.255 25.634 1.00 52.28  ? 505  ALA A C     1 ? 
ATOM   3905 O O     . ALA A 1 503 ? 10.285  -19.130 25.535 1.00 50.76  ? 505  ALA A O     1 ? 
ATOM   3906 C CB    . ALA A 1 503 ? 8.259   -18.112 23.544 1.00 50.68  ? 505  ALA A CB    1 ? 
ATOM   3907 N N     . SER A 1 504 ? 8.411   -19.260 26.794 1.00 56.63  ? 506  SER A N     1 ? 
ATOM   3908 C CA    . SER A 1 504 ? 9.118   -19.110 28.090 1.00 58.08  ? 506  SER A CA    1 ? 
ATOM   3909 C C     . SER A 1 504 ? 9.919   -17.795 28.096 1.00 56.69  ? 506  SER A C     1 ? 
ATOM   3910 O O     . SER A 1 504 ? 9.327   -16.716 27.905 1.00 60.82  ? 506  SER A O     1 ? 
ATOM   3911 C CB    . SER A 1 504 ? 9.998   -20.307 28.361 1.00 57.85  ? 506  SER A CB    1 ? 
ATOM   3912 O OG    . SER A 1 504 ? 10.472  -20.265 29.696 1.00 69.71  ? 506  SER A OG    1 ? 
ATOM   3913 N N     . SER A 1 505 ? 11.221  -17.864 28.335 1.00 51.85  ? 507  SER A N     1 ? 
ATOM   3914 C CA    . SER A 1 505 ? 12.050  -16.640 28.439 1.00 58.15  ? 507  SER A CA    1 ? 
ATOM   3915 C C     . SER A 1 505 ? 12.261  -15.988 27.050 1.00 58.89  ? 507  SER A C     1 ? 
ATOM   3916 O O     . SER A 1 505 ? 12.657  -14.833 26.962 1.00 61.38  ? 507  SER A O     1 ? 
ATOM   3917 C CB    . SER A 1 505 ? 13.363  -16.939 29.124 1.00 51.73  ? 507  SER A CB    1 ? 
ATOM   3918 O OG    . SER A 1 505 ? 14.263  -17.630 28.259 1.00 58.31  ? 507  SER A OG    1 ? 
ATOM   3919 N N     . GLY A 1 506 ? 11.982  -16.698 25.974 1.00 50.93  ? 508  GLY A N     1 ? 
ATOM   3920 C CA    . GLY A 1 506 ? 12.224  -16.196 24.618 1.00 57.75  ? 508  GLY A CA    1 ? 
ATOM   3921 C C     . GLY A 1 506 ? 13.641  -16.489 24.146 1.00 62.91  ? 508  GLY A C     1 ? 
ATOM   3922 O O     . GLY A 1 506 ? 14.018  -16.017 23.043 1.00 56.74  ? 508  GLY A O     1 ? 
ATOM   3923 N N     . SER A 1 507 ? 14.405  -17.241 24.932 1.00 63.52  ? 509  SER A N     1 ? 
ATOM   3924 C CA    . SER A 1 507 ? 15.773  -17.640 24.529 1.00 62.39  ? 509  SER A CA    1 ? 
ATOM   3925 C C     . SER A 1 507 ? 15.693  -18.624 23.373 1.00 59.09  ? 509  SER A C     1 ? 
ATOM   3926 O O     . SER A 1 507 ? 14.635  -19.248 23.194 1.00 63.56  ? 509  SER A O     1 ? 
ATOM   3927 C CB    . SER A 1 507 ? 16.543  -18.252 25.666 1.00 60.58  ? 509  SER A CB    1 ? 
ATOM   3928 O OG    . SER A 1 507 ? 16.043  -19.540 25.980 1.00 57.14  ? 509  SER A OG    1 ? 
ATOM   3929 N N     . LEU A 1 508 ? 16.798  -18.777 22.656 1.00 57.26  ? 510  LEU A N     1 ? 
ATOM   3930 C CA    . LEU A 1 508 ? 16.889  -19.705 21.500 1.00 58.01  ? 510  LEU A CA    1 ? 
ATOM   3931 C C     . LEU A 1 508 ? 16.635  -21.154 21.939 1.00 58.43  ? 510  LEU A C     1 ? 
ATOM   3932 O O     . LEU A 1 508 ? 15.998  -21.894 21.184 1.00 59.71  ? 510  LEU A O     1 ? 
ATOM   3933 C CB    . LEU A 1 508 ? 18.260  -19.550 20.837 1.00 55.98  ? 510  LEU A CB    1 ? 
ATOM   3934 C CG    . LEU A 1 508 ? 18.473  -18.199 20.157 1.00 57.22  ? 510  LEU A CG    1 ? 
ATOM   3935 C CD1   . LEU A 1 508 ? 19.764  -18.188 19.348 1.00 60.45  ? 510  LEU A CD1   1 ? 
ATOM   3936 C CD2   . LEU A 1 508 ? 17.314  -17.866 19.249 1.00 59.39  ? 510  LEU A CD2   1 ? 
ATOM   3937 N N     . ASP A 1 509 ? 17.095  -21.528 23.124 1.00 58.87  ? 511  ASP A N     1 ? 
ATOM   3938 C CA    . ASP A 1 509 ? 16.839  -22.877 23.673 1.00 57.08  ? 511  ASP A CA    1 ? 
ATOM   3939 C C     . ASP A 1 509 ? 15.347  -23.024 23.931 1.00 56.85  ? 511  ASP A C     1 ? 
ATOM   3940 O O     . ASP A 1 509 ? 14.790  -24.084 23.606 1.00 61.15  ? 511  ASP A O     1 ? 
ATOM   3941 C CB    . ASP A 1 509 ? 17.674  -23.099 24.935 1.00 59.00  ? 511  ASP A CB    1 ? 
ATOM   3942 C CG    . ASP A 1 509 ? 19.124  -23.449 24.624 1.00 65.32  ? 511  ASP A CG    1 ? 
ATOM   3943 O OD1   . ASP A 1 509 ? 19.490  -23.625 23.414 1.00 65.18  ? 511  ASP A OD1   1 ? 
ATOM   3944 O OD2   . ASP A 1 509 ? 19.886  -23.576 25.589 1.00 68.28  ? 511  ASP A OD2   1 ? 
ATOM   3945 N N     . ASP A 1 510 ? 14.733  -22.007 24.524 1.00 57.55  ? 512  ASP A N     1 ? 
ATOM   3946 C CA    . ASP A 1 510 ? 13.286  -22.041 24.835 1.00 54.07  ? 512  ASP A CA    1 ? 
ATOM   3947 C C     . ASP A 1 510 ? 12.507  -22.080 23.533 1.00 54.14  ? 512  ASP A C     1 ? 
ATOM   3948 O O     . ASP A 1 510 ? 11.509  -22.774 23.453 1.00 62.29  ? 512  ASP A O     1 ? 
ATOM   3949 C CB    . ASP A 1 510 ? 12.899  -20.855 25.698 1.00 59.03  ? 512  ASP A CB    1 ? 
ATOM   3950 C CG    . ASP A 1 510 ? 13.297  -21.036 27.153 1.00 63.31  ? 512  ASP A CG    1 ? 
ATOM   3951 O OD1   . ASP A 1 510 ? 13.742  -22.143 27.513 1.00 68.19  ? 512  ASP A OD1   1 ? 
ATOM   3952 O OD2   . ASP A 1 510 ? 13.133  -20.073 27.923 1.00 65.40  ? 512  ASP A OD2   1 ? 
ATOM   3953 N N     . LEU A 1 511 ? 12.975  -21.381 22.515 1.00 59.32  ? 513  LEU A N     1 ? 
ATOM   3954 C CA    . LEU A 1 511 ? 12.305  -21.419 21.192 1.00 56.75  ? 513  LEU A CA    1 ? 
ATOM   3955 C C     . LEU A 1 511 ? 12.466  -22.815 20.586 1.00 54.58  ? 513  LEU A C     1 ? 
ATOM   3956 O O     . LEU A 1 511 ? 11.527  -23.315 19.981 1.00 51.41  ? 513  LEU A O     1 ? 
ATOM   3957 C CB    . LEU A 1 511 ? 12.923  -20.345 20.301 1.00 54.58  ? 513  LEU A CB    1 ? 
ATOM   3958 C CG    . LEU A 1 511 ? 12.115  -19.072 20.095 1.00 59.51  ? 513  LEU A CG    1 ? 
ATOM   3959 C CD1   . LEU A 1 511 ? 11.530  -18.558 21.391 1.00 57.39  ? 513  LEU A CD1   1 ? 
ATOM   3960 C CD2   . LEU A 1 511 ? 12.987  -18.013 19.434 1.00 56.42  ? 513  LEU A CD2   1 ? 
ATOM   3961 N N     . ALA A 1 512 ? 13.629  -23.432 20.747 1.00 60.59  ? 514  ALA A N     1 ? 
ATOM   3962 C CA    . ALA A 1 512 ? 13.894  -24.793 20.226 1.00 57.05  ? 514  ALA A CA    1 ? 
ATOM   3963 C C     . ALA A 1 512 ? 13.045  -25.846 20.961 1.00 57.53  ? 514  ALA A C     1 ? 
ATOM   3964 O O     . ALA A 1 512 ? 12.734  -26.874 20.369 1.00 56.80  ? 514  ALA A O     1 ? 
ATOM   3965 C CB    . ALA A 1 512 ? 15.347  -25.114 20.356 1.00 58.24  ? 514  ALA A CB    1 ? 
ATOM   3966 N N     . ARG A 1 513 ? 12.654  -25.590 22.208 1.00 55.12  ? 515  ARG A N     1 ? 
ATOM   3967 C CA    . ARG A 1 513 ? 11.681  -26.474 22.893 1.00 56.85  ? 515  ARG A CA    1 ? 
ATOM   3968 C C     . ARG A 1 513 ? 10.312  -26.434 22.190 1.00 64.85  ? 515  ARG A C     1 ? 
ATOM   3969 O O     . ARG A 1 513 ? 9.547   -27.440 22.268 1.00 65.98  ? 515  ARG A O     1 ? 
ATOM   3970 C CB    . ARG A 1 513 ? 11.525  -26.089 24.364 1.00 59.45  ? 515  ARG A CB    1 ? 
ATOM   3971 C CG    . ARG A 1 513 ? 12.797  -26.273 25.168 1.00 67.92  ? 515  ARG A CG    1 ? 
ATOM   3972 C CD    . ARG A 1 513 ? 12.568  -25.944 26.627 1.00 79.22  ? 515  ARG A CD    1 ? 
ATOM   3973 N NE    . ARG A 1 513 ? 11.673  -26.890 27.284 1.00 85.92  ? 515  ARG A NE    1 ? 
ATOM   3974 C CZ    . ARG A 1 513 ? 10.553  -26.571 27.926 1.00 88.86  ? 515  ARG A CZ    1 ? 
ATOM   3975 N NH1   . ARG A 1 513 ? 10.161  -25.303 28.020 1.00 91.26  ? 515  ARG A NH1   1 ? 
ATOM   3976 N NH2   . ARG A 1 513 ? 9.830   -27.530 28.477 1.00 75.81  ? 515  ARG A NH2   1 ? 
ATOM   3977 N N     . VAL A 1 514 ? 9.990   -25.338 21.510 1.00 60.86  ? 516  VAL A N     1 ? 
ATOM   3978 C CA    . VAL A 1 514 ? 8.679   -25.214 20.808 1.00 59.75  ? 516  VAL A CA    1 ? 
ATOM   3979 C C     . VAL A 1 514 ? 8.753   -25.860 19.413 1.00 57.60  ? 516  VAL A C     1 ? 
ATOM   3980 O O     . VAL A 1 514 ? 7.761   -26.456 18.966 1.00 57.00  ? 516  VAL A O     1 ? 
ATOM   3981 C CB    . VAL A 1 514 ? 8.247   -23.754 20.718 1.00 56.54  ? 516  VAL A CB    1 ? 
ATOM   3982 C CG1   . VAL A 1 514 ? 6.903   -23.628 20.041 1.00 59.86  ? 516  VAL A CG1   1 ? 
ATOM   3983 C CG2   . VAL A 1 514 ? 8.204   -23.109 22.085 1.00 49.23  ? 516  VAL A CG2   1 ? 
ATOM   3984 N N     . PHE A 1 515 ? 9.912   -25.789 18.766 1.00 58.68  ? 517  PHE A N     1 ? 
ATOM   3985 C CA    . PHE A 1 515 ? 10.131  -26.433 17.451 1.00 63.30  ? 517  PHE A CA    1 ? 
ATOM   3986 C C     . PHE A 1 515 ? 11.282  -27.423 17.536 1.00 64.96  ? 517  PHE A C     1 ? 
ATOM   3987 O O     . PHE A 1 515 ? 12.384  -27.104 17.122 1.00 65.19  ? 517  PHE A O     1 ? 
ATOM   3988 C CB    . PHE A 1 515 ? 10.382  -25.365 16.394 1.00 61.95  ? 517  PHE A CB    1 ? 
ATOM   3989 C CG    . PHE A 1 515 ? 9.258   -24.382 16.255 1.00 58.23  ? 517  PHE A CG    1 ? 
ATOM   3990 C CD1   . PHE A 1 515 ? 8.180   -24.650 15.434 1.00 61.05  ? 517  PHE A CD1   1 ? 
ATOM   3991 C CD2   . PHE A 1 515 ? 9.275   -23.205 16.973 1.00 57.43  ? 517  PHE A CD2   1 ? 
ATOM   3992 C CE1   . PHE A 1 515 ? 7.142   -23.742 15.328 1.00 59.87  ? 517  PHE A CE1   1 ? 
ATOM   3993 C CE2   . PHE A 1 515 ? 8.232   -22.305 16.878 1.00 56.22  ? 517  PHE A CE2   1 ? 
ATOM   3994 C CZ    . PHE A 1 515 ? 7.184   -22.566 16.039 1.00 58.33  ? 517  PHE A CZ    1 ? 
ATOM   3995 N N     . PRO A 1 516 ? 11.057  -28.652 18.055 1.00 66.89  ? 518  PRO A N     1 ? 
ATOM   3996 C CA    . PRO A 1 516 ? 12.146  -29.615 18.193 1.00 69.58  ? 518  PRO A CA    1 ? 
ATOM   3997 C C     . PRO A 1 516 ? 12.612  -30.190 16.848 1.00 69.12  ? 518  PRO A C     1 ? 
ATOM   3998 O O     . PRO A 1 516 ? 13.738  -30.659 16.809 1.00 70.60  ? 518  PRO A O     1 ? 
ATOM   3999 C CB    . PRO A 1 516 ? 11.539  -30.712 19.076 1.00 68.46  ? 518  PRO A CB    1 ? 
ATOM   4000 C CG    . PRO A 1 516 ? 10.067  -30.657 18.764 1.00 67.83  ? 518  PRO A CG    1 ? 
ATOM   4001 C CD    . PRO A 1 516 ? 9.768   -29.188 18.531 1.00 62.86  ? 518  PRO A CD    1 ? 
ATOM   4002 N N     . THR A 1 517 ? 11.750  -30.178 15.826 1.00 67.90  ? 519  THR A N     1 ? 
ATOM   4003 C CA    . THR A 1 517 ? 12.100  -30.631 14.450 1.00 72.51  ? 519  THR A CA    1 ? 
ATOM   4004 C C     . THR A 1 517 ? 11.727  -29.528 13.469 1.00 72.74  ? 519  THR A C     1 ? 
ATOM   4005 O O     . THR A 1 517 ? 10.787  -29.663 12.688 1.00 72.66  ? 519  THR A O     1 ? 
ATOM   4006 C CB    . THR A 1 517 ? 11.403  -31.955 14.111 1.00 74.52  ? 519  THR A CB    1 ? 
ATOM   4007 O OG1   . THR A 1 517 ? 10.023  -31.765 13.783 1.00 74.89  ? 519  THR A OG1   1 ? 
ATOM   4008 C CG2   . THR A 1 517 ? 11.424  -32.920 15.269 1.00 78.83  ? 519  THR A CG2   1 ? 
ATOM   4009 N N     . PRO A 1 518 ? 12.446  -28.390 13.502 1.00 73.70  ? 520  PRO A N     1 ? 
ATOM   4010 C CA    . PRO A 1 518 ? 12.014  -27.207 12.761 1.00 70.57  ? 520  PRO A CA    1 ? 
ATOM   4011 C C     . PRO A 1 518 ? 11.986  -27.397 11.236 1.00 72.55  ? 520  PRO A C     1 ? 
ATOM   4012 O O     . PRO A 1 518 ? 11.310  -26.613 10.580 1.00 73.48  ? 520  PRO A O     1 ? 
ATOM   4013 C CB    . PRO A 1 518 ? 13.048  -26.147 13.155 1.00 69.74  ? 520  PRO A CB    1 ? 
ATOM   4014 C CG    . PRO A 1 518 ? 14.265  -26.937 13.551 1.00 68.98  ? 520  PRO A CG    1 ? 
ATOM   4015 C CD    . PRO A 1 518 ? 13.715  -28.179 14.221 1.00 67.64  ? 520  PRO A CD    1 ? 
ATOM   4016 N N     . GLU A 1 519 ? 12.679  -28.414 10.710 0.60 62.67  ? 521  GLU A N     1 ? 
ATOM   4017 C CA    . GLU A 1 519 ? 12.750  -28.629 9.238  0.60 64.54  ? 521  GLU A CA    1 ? 
ATOM   4018 C C     . GLU A 1 519 ? 11.409  -29.143 8.717  0.60 61.23  ? 521  GLU A C     1 ? 
ATOM   4019 O O     . GLU A 1 519 ? 11.183  -29.047 7.504  0.60 60.83  ? 521  GLU A O     1 ? 
ATOM   4020 C CB    . GLU A 1 519 ? 13.870  -29.586 8.838  0.60 69.15  ? 521  GLU A CB    1 ? 
ATOM   4021 C CG    . GLU A 1 519 ? 13.929  -30.841 9.692  0.60 77.48  ? 521  GLU A CG    1 ? 
ATOM   4022 C CD    . GLU A 1 519 ? 14.779  -30.696 10.947 0.60 88.61  ? 521  GLU A CD    1 ? 
ATOM   4023 O OE1   . GLU A 1 519 ? 15.539  -29.663 11.077 0.60 80.51  ? 521  GLU A OE1   1 ? 
ATOM   4024 O OE2   . GLU A 1 519 ? 14.682  -31.614 11.798 0.60 91.38  ? 521  GLU A OE2   1 ? 
ATOM   4025 N N     . LYS A 1 520 ? 10.539  -29.633 9.593  1.00 62.82  ? 522  LYS A N     1 ? 
ATOM   4026 C CA    . LYS A 1 520 ? 9.202   -30.162 9.200  1.00 72.17  ? 522  LYS A CA    1 ? 
ATOM   4027 C C     . LYS A 1 520 ? 8.085   -29.133 9.415  1.00 73.30  ? 522  LYS A C     1 ? 
ATOM   4028 O O     . LYS A 1 520 ? 6.904   -29.501 9.258  1.00 68.30  ? 522  LYS A O     1 ? 
ATOM   4029 C CB    . LYS A 1 520 ? 8.870   -31.395 10.032 1.00 74.54  ? 522  LYS A CB    1 ? 
ATOM   4030 C CG    . LYS A 1 520 ? 9.937   -32.479 9.987  1.00 76.95  ? 522  LYS A CG    1 ? 
ATOM   4031 C CD    . LYS A 1 520 ? 9.433   -33.739 10.637 1.00 83.65  ? 522  LYS A CD    1 ? 
ATOM   4032 C CE    . LYS A 1 520 ? 10.551  -34.652 11.088 1.00 90.21  ? 522  LYS A CE    1 ? 
ATOM   4033 N NZ    . LYS A 1 520 ? 10.058  -35.592 12.127 1.00 86.71  ? 522  LYS A NZ    1 ? 
ATOM   4034 N N     . VAL A 1 521 ? 8.438   -27.900 9.769  1.00 68.45  ? 523  VAL A N     1 ? 
ATOM   4035 C CA    . VAL A 1 521 ? 7.447   -26.813 9.966  1.00 61.03  ? 523  VAL A CA    1 ? 
ATOM   4036 C C     . VAL A 1 521 ? 7.604   -25.792 8.842  1.00 59.57  ? 523  VAL A C     1 ? 
ATOM   4037 O O     . VAL A 1 521 ? 8.639   -25.146 8.772  1.00 59.38  ? 523  VAL A O     1 ? 
ATOM   4038 C CB    . VAL A 1 521 ? 7.611   -26.167 11.341 1.00 62.45  ? 523  VAL A CB    1 ? 
ATOM   4039 C CG1   . VAL A 1 521 ? 6.580   -25.067 11.550 1.00 62.88  ? 523  VAL A CG1   1 ? 
ATOM   4040 C CG2   . VAL A 1 521 ? 7.509   -27.210 12.437 1.00 63.13  ? 523  VAL A CG2   1 ? 
ATOM   4041 N N     . HIS A 1 522 ? 6.583   -25.684 7.998  1.00 59.54  ? 524  HIS A N     1 ? 
ATOM   4042 C CA    . HIS A 1 522 ? 6.590   -24.835 6.783  1.00 67.32  ? 524  HIS A CA    1 ? 
ATOM   4043 C C     . HIS A 1 522 ? 5.475   -23.804 6.888  1.00 67.17  ? 524  HIS A C     1 ? 
ATOM   4044 O O     . HIS A 1 522 ? 4.275   -24.167 6.738  1.00 63.31  ? 524  HIS A O     1 ? 
ATOM   4045 C CB    . HIS A 1 522 ? 6.453   -25.671 5.509  1.00 69.50  ? 524  HIS A CB    1 ? 
ATOM   4046 C CG    . HIS A 1 522 ? 7.391   -26.828 5.450  1.00 80.82  ? 524  HIS A CG    1 ? 
ATOM   4047 N ND1   . HIS A 1 522 ? 8.743   -26.675 5.164  1.00 75.27  ? 524  HIS A ND1   1 ? 
ATOM   4048 C CD2   . HIS A 1 522 ? 7.180   -28.155 5.636  1.00 75.92  ? 524  HIS A CD2   1 ? 
ATOM   4049 C CE1   . HIS A 1 522 ? 9.320   -27.863 5.173  1.00 79.94  ? 524  HIS A CE1   1 ? 
ATOM   4050 N NE2   . HIS A 1 522 ? 8.386   -28.787 5.466  1.00 80.57  ? 524  HIS A NE2   1 ? 
ATOM   4051 N N     . ILE A 1 523 ? 5.866   -22.575 7.188  1.00 61.73  ? 525  ILE A N     1 ? 
ATOM   4052 C CA    . ILE A 1 523 ? 4.917   -21.450 7.348  1.00 55.78  ? 525  ILE A CA    1 ? 
ATOM   4053 C C     . ILE A 1 523 ? 5.128   -20.560 6.142  1.00 56.27  ? 525  ILE A C     1 ? 
ATOM   4054 O O     . ILE A 1 523 ? 6.227   -20.051 5.956  1.00 51.95  ? 525  ILE A O     1 ? 
ATOM   4055 C CB    . ILE A 1 523 ? 5.130   -20.719 8.674  1.00 55.56  ? 525  ILE A CB    1 ? 
ATOM   4056 C CG1   . ILE A 1 523 ? 5.025   -21.698 9.849  1.00 52.62  ? 525  ILE A CG1   1 ? 
ATOM   4057 C CG2   . ILE A 1 523 ? 4.142   -19.577 8.788  1.00 53.45  ? 525  ILE A CG2   1 ? 
ATOM   4058 C CD1   . ILE A 1 523 ? 5.491   -21.117 11.157 1.00 57.85  ? 525  ILE A CD1   1 ? 
ATOM   4059 N N     . ASP A 1 524 ? 4.077   -20.397 5.363  1.00 61.46  ? 526  ASP A N     1 ? 
ATOM   4060 C CA    . ASP A 1 524 ? 4.119   -19.553 4.154  1.00 59.97  ? 526  ASP A CA    1 ? 
ATOM   4061 C C     . ASP A 1 524 ? 4.240   -18.093 4.569  1.00 56.94  ? 526  ASP A C     1 ? 
ATOM   4062 O O     . ASP A 1 524 ? 3.756   -17.761 5.655  1.00 61.09  ? 526  ASP A O     1 ? 
ATOM   4063 C CB    . ASP A 1 524 ? 2.863   -19.787 3.322  1.00 64.50  ? 526  ASP A CB    1 ? 
ATOM   4064 C CG    . ASP A 1 524 ? 2.821   -18.888 2.123  1.00 64.83  ? 526  ASP A CG    1 ? 
ATOM   4065 O OD1   . ASP A 1 524 ? 3.679   -19.079 1.254  1.00 70.63  ? 526  ASP A OD1   1 ? 
ATOM   4066 O OD2   . ASP A 1 524 ? 1.980   -17.988 2.123  1.00 69.37  ? 526  ASP A OD2   1 ? 
ATOM   4067 N N     . GLN A 1 525 ? 4.846   -17.285 3.694  1.00 61.84  ? 527  GLN A N     1 ? 
ATOM   4068 C CA    . GLN A 1 525 ? 5.169   -15.857 3.928  1.00 56.32  ? 527  GLN A CA    1 ? 
ATOM   4069 C C     . GLN A 1 525 ? 3.925   -15.009 4.202  1.00 52.39  ? 527  GLN A C     1 ? 
ATOM   4070 O O     . GLN A 1 525 ? 4.113   -13.971 4.817  1.00 57.64  ? 527  GLN A O     1 ? 
ATOM   4071 C CB    . GLN A 1 525 ? 5.925   -15.289 2.740  1.00 57.74  ? 527  GLN A CB    1 ? 
ATOM   4072 C CG    . GLN A 1 525 ? 5.179   -15.386 1.428  1.00 57.07  ? 527  GLN A CG    1 ? 
ATOM   4073 C CD    . GLN A 1 525 ? 5.961   -14.744 0.303  1.00 60.85  ? 527  GLN A CD    1 ? 
ATOM   4074 O OE1   . GLN A 1 525 ? 6.705   -13.783 0.504  1.00 66.09  ? 527  GLN A OE1   1 ? 
ATOM   4075 N NE2   . GLN A 1 525 ? 5.801   -15.293 -0.891 1.00 56.47  ? 527  GLN A NE2   1 ? 
ATOM   4076 N N     . HIS A 1 526 ? 2.740   -15.443 3.763  1.00 53.21  ? 528  HIS A N     1 ? 
ATOM   4077 C CA    . HIS A 1 526 ? 1.452   -14.734 3.996  1.00 55.40  ? 528  HIS A CA    1 ? 
ATOM   4078 C C     . HIS A 1 526 ? 0.699   -15.308 5.199  1.00 50.74  ? 528  HIS A C     1 ? 
ATOM   4079 O O     . HIS A 1 526 ? -0.384  -14.818 5.460  1.00 59.56  ? 528  HIS A O     1 ? 
ATOM   4080 C CB    . HIS A 1 526 ? 0.537   -14.773 2.765  1.00 50.40  ? 528  HIS A CB    1 ? 
ATOM   4081 C CG    . HIS A 1 526 ? 1.185   -14.268 1.525  1.00 61.07  ? 528  HIS A CG    1 ? 
ATOM   4082 N ND1   . HIS A 1 526 ? 1.719   -15.115 0.557  1.00 60.76  ? 528  HIS A ND1   1 ? 
ATOM   4083 C CD2   . HIS A 1 526 ? 1.400   -13.013 1.075  1.00 67.71  ? 528  HIS A CD2   1 ? 
ATOM   4084 C CE1   . HIS A 1 526 ? 2.238   -14.399 -0.420 1.00 56.98  ? 528  HIS A CE1   1 ? 
ATOM   4085 N NE2   . HIS A 1 526 ? 2.042   -13.114 -0.148 1.00 60.31  ? 528  HIS A NE2   1 ? 
ATOM   4086 N N     . SER A 1 527 ? 1.275   -16.248 5.923  1.00 54.62  ? 529  SER A N     1 ? 
ATOM   4087 C CA    . SER A 1 527 ? 0.542   -16.971 6.990  1.00 55.78  ? 529  SER A CA    1 ? 
ATOM   4088 C C     . SER A 1 527 ? 0.612   -16.196 8.305  1.00 55.70  ? 529  SER A C     1 ? 
ATOM   4089 O O     . SER A 1 527 ? 1.460   -15.280 8.454  1.00 54.77  ? 529  SER A O     1 ? 
ATOM   4090 C CB    . SER A 1 527 ? 1.049   -18.371 7.144  1.00 55.33  ? 529  SER A CB    1 ? 
ATOM   4091 O OG    . SER A 1 527 ? 0.715   -19.121 5.995  1.00 62.50  ? 529  SER A OG    1 ? 
ATOM   4092 N N     . THR A 1 528 ? -0.277  -16.571 9.219  1.00 53.56  ? 530  THR A N     1 ? 
ATOM   4093 C CA    . THR A 1 528 ? -0.308  -16.046 10.596 1.00 52.29  ? 530  THR A CA    1 ? 
ATOM   4094 C C     . THR A 1 528 ? -0.369  -17.222 11.564 1.00 52.17  ? 530  THR A C     1 ? 
ATOM   4095 O O     . THR A 1 528 ? -1.269  -18.074 11.409 1.00 55.61  ? 530  THR A O     1 ? 
ATOM   4096 C CB    . THR A 1 528 ? -1.506  -15.112 10.807 1.00 55.90  ? 530  THR A CB    1 ? 
ATOM   4097 O OG1   . THR A 1 528 ? -1.427  -13.955 9.978  1.00 55.64  ? 530  THR A OG1   1 ? 
ATOM   4098 C CG2   . THR A 1 528 ? -1.603  -14.677 12.256 1.00 58.65  ? 530  THR A CG2   1 ? 
ATOM   4099 N N     . LEU A 1 529 ? 0.538   -17.237 12.531 1.00 49.41  ? 531  LEU A N     1 ? 
ATOM   4100 C CA    . LEU A 1 529 ? 0.582   -18.311 13.550 1.00 51.47  ? 531  LEU A CA    1 ? 
ATOM   4101 C C     . LEU A 1 529 ? 0.594   -17.708 14.961 1.00 54.50  ? 531  LEU A C     1 ? 
ATOM   4102 O O     . LEU A 1 529 ? 1.604   -17.096 15.345 1.00 55.12  ? 531  LEU A O     1 ? 
ATOM   4103 C CB    . LEU A 1 529 ? 1.810   -19.181 13.341 1.00 50.51  ? 531  LEU A CB    1 ? 
ATOM   4104 C CG    . LEU A 1 529 ? 1.974   -20.288 14.385 1.00 52.11  ? 531  LEU A CG    1 ? 
ATOM   4105 C CD1   . LEU A 1 529 ? 0.837   -21.275 14.293 1.00 52.85  ? 531  LEU A CD1   1 ? 
ATOM   4106 C CD2   . LEU A 1 529 ? 3.310   -21.004 14.206 1.00 52.03  ? 531  LEU A CD2   1 ? 
ATOM   4107 N N     . ILE A 1 530 ? -0.521  -17.831 15.664 1.00 49.96  ? 532  ILE A N     1 ? 
ATOM   4108 C CA    . ILE A 1 530 ? -0.643  -17.390 17.071 1.00 47.29  ? 532  ILE A CA    1 ? 
ATOM   4109 C C     . ILE A 1 530 ? -0.592  -18.642 17.937 1.00 52.66  ? 532  ILE A C     1 ? 
ATOM   4110 O O     . ILE A 1 530 ? -1.361  -19.591 17.707 1.00 53.23  ? 532  ILE A O     1 ? 
ATOM   4111 C CB    . ILE A 1 530 ? -1.930  -16.591 17.309 1.00 51.74  ? 532  ILE A CB    1 ? 
ATOM   4112 C CG1   . ILE A 1 530 ? -2.109  -15.479 16.269 1.00 54.25  ? 532  ILE A CG1   1 ? 
ATOM   4113 C CG2   . ILE A 1 530 ? -1.966  -16.034 18.719 1.00 53.43  ? 532  ILE A CG2   1 ? 
ATOM   4114 C CD1   . ILE A 1 530 ? -1.056  -14.414 16.325 1.00 59.43  ? 532  ILE A CD1   1 ? 
ATOM   4115 N N     . VAL A 1 531 ? 0.326   -18.653 18.888 1.00 49.73  ? 533  VAL A N     1 ? 
ATOM   4116 C CA    . VAL A 1 531 ? 0.486   -19.807 19.802 1.00 51.14  ? 533  VAL A CA    1 ? 
ATOM   4117 C C     . VAL A 1 531 ? 0.341   -19.322 21.233 1.00 54.10  ? 533  VAL A C     1 ? 
ATOM   4118 O O     . VAL A 1 531 ? 1.087   -18.430 21.658 1.00 61.77  ? 533  VAL A O     1 ? 
ATOM   4119 C CB    . VAL A 1 531 ? 1.808   -20.533 19.583 1.00 53.71  ? 533  VAL A CB    1 ? 
ATOM   4120 C CG1   . VAL A 1 531 ? 1.868   -21.782 20.431 1.00 51.27  ? 533  VAL A CG1   1 ? 
ATOM   4121 C CG2   . VAL A 1 531 ? 1.982   -20.884 18.115 1.00 53.97  ? 533  VAL A CG2   1 ? 
ATOM   4122 N N     . GLU A 1 532 ? -0.645  -19.881 21.922 1.00 57.52  ? 534  GLU A N     1 ? 
ATOM   4123 C CA    . GLU A 1 532 ? -0.942  -19.550 23.331 1.00 55.70  ? 534  GLU A CA    1 ? 
ATOM   4124 C C     . GLU A 1 532 ? -0.827  -20.818 24.178 1.00 56.34  ? 534  GLU A C     1 ? 
ATOM   4125 O O     . GLU A 1 532 ? -1.287  -21.882 23.757 1.00 60.57  ? 534  GLU A O     1 ? 
ATOM   4126 C CB    . GLU A 1 532 ? -2.323  -18.917 23.458 1.00 56.79  ? 534  GLU A CB    1 ? 
ATOM   4127 C CG    . GLU A 1 532 ? -2.572  -17.779 22.517 1.00 61.91  ? 534  GLU A CG    1 ? 
ATOM   4128 C CD    . GLU A 1 532 ? -3.948  -17.160 22.665 1.00 71.02  ? 534  GLU A CD    1 ? 
ATOM   4129 O OE1   . GLU A 1 532 ? -4.873  -17.872 23.114 1.00 75.85  ? 534  GLU A OE1   1 ? 
ATOM   4130 O OE2   . GLU A 1 532 ? -4.090  -15.969 22.342 1.00 73.25  ? 534  GLU A OE2   1 ? 
ATOM   4131 N N     . GLY A 1 533 ? -0.209  -20.691 25.336 1.00 59.51  ? 535  GLY A N     1 ? 
ATOM   4132 C CA    . GLY A 1 533 ? -0.094  -21.788 26.308 1.00 62.33  ? 535  GLY A CA    1 ? 
ATOM   4133 C C     . GLY A 1 533 ? 1.024   -22.757 25.991 1.00 61.25  ? 535  GLY A C     1 ? 
ATOM   4134 O O     . GLY A 1 533 ? 1.840   -22.513 25.073 1.00 64.33  ? 535  GLY A O     1 ? 
ATOM   4135 N N     . ARG A 1 534 ? 1.029   -23.863 26.719 1.00 68.93  ? 536  ARG A N     1 ? 
ATOM   4136 C CA    . ARG A 1 534 ? 2.082   -24.893 26.596 1.00 67.98  ? 536  ARG A CA    1 ? 
ATOM   4137 C C     . ARG A 1 534 ? 1.857   -25.708 25.327 1.00 63.56  ? 536  ARG A C     1 ? 
ATOM   4138 O O     . ARG A 1 534 ? 1.105   -26.674 25.349 1.00 68.54  ? 536  ARG A O     1 ? 
ATOM   4139 C CB    . ARG A 1 534 ? 2.082   -25.761 27.850 1.00 70.54  ? 536  ARG A CB    1 ? 
ATOM   4140 C CG    . ARG A 1 534 ? 3.308   -26.647 27.977 1.00 80.32  ? 536  ARG A CG    1 ? 
ATOM   4141 C CD    . ARG A 1 534 ? 4.588   -25.849 28.188 1.00 86.02  ? 536  ARG A CD    1 ? 
ATOM   4142 N NE    . ARG A 1 534 ? 5.775   -26.637 27.853 1.00 84.71  ? 536  ARG A NE    1 ? 
ATOM   4143 C CZ    . ARG A 1 534 ? 6.446   -26.543 26.691 1.00 89.02  ? 536  ARG A CZ    1 ? 
ATOM   4144 N NH1   . ARG A 1 534 ? 6.089   -25.678 25.740 1.00 80.52  ? 536  ARG A NH1   1 ? 
ATOM   4145 N NH2   . ARG A 1 534 ? 7.498   -27.312 26.495 1.00 82.39  ? 536  ARG A NH2   1 ? 
ATOM   4146 N N     . VAL A 1 535 ? 2.521   -25.327 24.250 1.00 66.62  ? 537  VAL A N     1 ? 
ATOM   4147 C CA    . VAL A 1 535 ? 2.361   -25.997 22.936 1.00 62.38  ? 537  VAL A CA    1 ? 
ATOM   4148 C C     . VAL A 1 535 ? 3.736   -26.382 22.430 1.00 55.51  ? 537  VAL A C     1 ? 
ATOM   4149 O O     . VAL A 1 535 ? 4.676   -25.610 22.616 1.00 59.04  ? 537  VAL A O     1 ? 
ATOM   4150 C CB    . VAL A 1 535 ? 1.623   -25.099 21.937 1.00 61.07  ? 537  VAL A CB    1 ? 
ATOM   4151 C CG1   . VAL A 1 535 ? 1.483   -25.781 20.596 1.00 64.10  ? 537  VAL A CG1   1 ? 
ATOM   4152 C CG2   . VAL A 1 535 ? 0.269   -24.684 22.473 1.00 63.98  ? 537  VAL A CG2   1 ? 
ATOM   4153 N N     . ILE A 1 536 ? 3.806   -27.550 21.808 1.00 59.66  ? 538  ILE A N     1 ? 
ATOM   4154 C CA    . ILE A 1 536 ? 4.988   -28.034 21.058 1.00 58.35  ? 538  ILE A CA    1 ? 
ATOM   4155 C C     . ILE A 1 536 ? 4.524   -28.322 19.644 1.00 64.54  ? 538  ILE A C     1 ? 
ATOM   4156 O O     . ILE A 1 536 ? 3.477   -28.976 19.499 1.00 71.86  ? 538  ILE A O     1 ? 
ATOM   4157 C CB    . ILE A 1 536 ? 5.604   -29.276 21.711 1.00 54.95  ? 538  ILE A CB    1 ? 
ATOM   4158 C CG1   . ILE A 1 536 ? 6.043   -28.955 23.141 1.00 57.25  ? 538  ILE A CG1   1 ? 
ATOM   4159 C CG2   . ILE A 1 536 ? 6.747   -29.797 20.863 1.00 46.19  ? 538  ILE A CG2   1 ? 
ATOM   4160 C CD1   . ILE A 1 536 ? 6.559   -30.151 23.913 1.00 61.05  ? 538  ILE A CD1   1 ? 
ATOM   4161 N N     . ILE A 1 537 ? 5.260   -27.811 18.663 1.00 57.74  ? 539  ILE A N     1 ? 
ATOM   4162 C CA    . ILE A 1 537 ? 4.910   -27.996 17.235 1.00 60.58  ? 539  ILE A CA    1 ? 
ATOM   4163 C C     . ILE A 1 537 ? 6.017   -28.807 16.577 1.00 64.45  ? 539  ILE A C     1 ? 
ATOM   4164 O O     . ILE A 1 537 ? 7.127   -28.267 16.357 1.00 66.97  ? 539  ILE A O     1 ? 
ATOM   4165 C CB    . ILE A 1 537 ? 4.682   -26.661 16.521 1.00 59.15  ? 539  ILE A CB    1 ? 
ATOM   4166 C CG1   . ILE A 1 537 ? 3.539   -25.866 17.154 1.00 55.49  ? 539  ILE A CG1   1 ? 
ATOM   4167 C CG2   . ILE A 1 537 ? 4.426   -26.892 15.041 1.00 60.19  ? 539  ILE A CG2   1 ? 
ATOM   4168 C CD1   . ILE A 1 537 ? 3.569   -24.415 16.788 1.00 58.72  ? 539  ILE A CD1   1 ? 
ATOM   4169 N N     . GLU A 1 538 ? 5.699   -30.037 16.199 1.00 64.86  ? 540  GLU A N     1 ? 
ATOM   4170 C CA    . GLU A 1 538 ? 6.674   -30.944 15.560 1.00 64.14  ? 540  GLU A CA    1 ? 
ATOM   4171 C C     . GLU A 1 538 ? 6.610   -30.790 14.045 1.00 63.92  ? 540  GLU A C     1 ? 
ATOM   4172 O O     . GLU A 1 538 ? 7.658   -30.590 13.422 1.00 70.78  ? 540  GLU A O     1 ? 
ATOM   4173 C CB    . GLU A 1 538 ? 6.365   -32.380 15.956 1.00 69.99  ? 540  GLU A CB    1 ? 
ATOM   4174 C CG    . GLU A 1 538 ? 6.751   -32.714 17.383 1.00 78.58  ? 540  GLU A CG    1 ? 
ATOM   4175 C CD    . GLU A 1 538 ? 6.627   -34.198 17.698 1.00 88.15  ? 540  GLU A CD    1 ? 
ATOM   4176 O OE1   . GLU A 1 538 ? 6.148   -34.966 16.803 1.00 80.62  ? 540  GLU A OE1   1 ? 
ATOM   4177 O OE2   . GLU A 1 538 ? 7.005   -34.592 18.830 1.00 90.35  ? 540  GLU A OE2   1 ? 
ATOM   4178 N N     . SER A 1 539 ? 5.419   -30.924 13.473 1.00 66.65  ? 541  SER A N     1 ? 
ATOM   4179 C CA    . SER A 1 539 ? 5.234   -30.857 12.005 1.00 68.57  ? 541  SER A CA    1 ? 
ATOM   4180 C C     . SER A 1 539 ? 3.991   -30.028 11.728 1.00 60.71  ? 541  SER A C     1 ? 
ATOM   4181 O O     . SER A 1 539 ? 3.002   -30.210 12.399 1.00 65.31  ? 541  SER A O     1 ? 
ATOM   4182 C CB    . SER A 1 539 ? 5.159   -32.221 11.365 1.00 70.45  ? 541  SER A CB    1 ? 
ATOM   4183 O OG    . SER A 1 539 ? 4.363   -33.083 12.144 1.00 71.52  ? 541  SER A OG    1 ? 
ATOM   4184 N N     . LEU A 1 540 ? 4.088   -29.121 10.776 1.00 65.92  ? 542  LEU A N     1 ? 
ATOM   4185 C CA    . LEU A 1 540 ? 2.980   -28.210 10.425 1.00 64.44  ? 542  LEU A CA    1 ? 
ATOM   4186 C C     . LEU A 1 540 ? 3.207   -27.685 9.010  1.00 67.21  ? 542  LEU A C     1 ? 
ATOM   4187 O O     . LEU A 1 540 ? 4.361   -27.395 8.633  1.00 66.56  ? 542  LEU A O     1 ? 
ATOM   4188 C CB    . LEU A 1 540 ? 2.899   -27.069 11.444 1.00 64.83  ? 542  LEU A CB    1 ? 
ATOM   4189 C CG    . LEU A 1 540 ? 1.867   -25.967 11.157 1.00 66.26  ? 542  LEU A CG    1 ? 
ATOM   4190 C CD1   . LEU A 1 540 ? 0.453   -26.526 11.078 1.00 64.72  ? 542  LEU A CD1   1 ? 
ATOM   4191 C CD2   . LEU A 1 540 ? 1.920   -24.875 12.240 1.00 64.39  ? 542  LEU A CD2   1 ? 
ATOM   4192 N N     . GLU A 1 541 ? 2.130   -27.607 8.250  1.00 63.76  ? 543  GLU A N     1 ? 
ATOM   4193 C CA    . GLU A 1 541 ? 2.116   -26.945 6.932  1.00 72.01  ? 543  GLU A CA    1 ? 
ATOM   4194 C C     . GLU A 1 541 ? 0.986   -25.915 6.954  1.00 69.41  ? 543  GLU A C     1 ? 
ATOM   4195 O O     . GLU A 1 541 ? -0.203  -26.324 6.995  1.00 74.48  ? 543  GLU A O     1 ? 
ATOM   4196 C CB    . GLU A 1 541 ? 1.939   -27.990 5.834  1.00 85.15  ? 543  GLU A CB    1 ? 
ATOM   4197 C CG    . GLU A 1 541 ? 2.754   -27.700 4.588  1.00 89.35  ? 543  GLU A CG    1 ? 
ATOM   4198 C CD    . GLU A 1 541 ? 2.173   -28.344 3.336  1.00 104.12 ? 543  GLU A CD    1 ? 
ATOM   4199 O OE1   . GLU A 1 541 ? 1.742   -27.582 2.435  1.00 98.26  ? 543  GLU A OE1   1 ? 
ATOM   4200 O OE2   . GLU A 1 541 ? 2.134   -29.608 3.263  1.00 97.38  ? 543  GLU A OE2   1 ? 
ATOM   4201 N N     . LEU A 1 542 ? 1.342   -24.629 6.986  1.00 62.30  ? 544  LEU A N     1 ? 
ATOM   4202 C CA    . LEU A 1 542 ? 0.365   -23.540 7.264  1.00 63.54  ? 544  LEU A CA    1 ? 
ATOM   4203 C C     . LEU A 1 542 ? 0.298   -22.601 6.067  1.00 58.58  ? 544  LEU A C     1 ? 
ATOM   4204 O O     . LEU A 1 542 ? 1.318   -21.960 5.719  1.00 60.39  ? 544  LEU A O     1 ? 
ATOM   4205 C CB    . LEU A 1 542 ? 0.743   -22.772 8.528  1.00 61.41  ? 544  LEU A CB    1 ? 
ATOM   4206 C CG    . LEU A 1 542 ? -0.099  -21.522 8.784  1.00 64.56  ? 544  LEU A CG    1 ? 
ATOM   4207 C CD1   . LEU A 1 542 ? -1.579  -21.846 8.877  1.00 59.57  ? 544  LEU A CD1   1 ? 
ATOM   4208 C CD2   . LEU A 1 542 ? 0.362   -20.829 10.051 1.00 59.87  ? 544  LEU A CD2   1 ? 
ATOM   4209 N N     . TYR A 1 543 ? -0.876  -22.534 5.461  1.00 62.65  ? 545  TYR A N     1 ? 
ATOM   4210 C CA    . TYR A 1 543 ? -1.176  -21.580 4.368  1.00 68.90  ? 545  TYR A CA    1 ? 
ATOM   4211 C C     . TYR A 1 543 ? -2.416  -20.793 4.764  1.00 71.84  ? 545  TYR A C     1 ? 
ATOM   4212 O O     . TYR A 1 543 ? -3.532  -21.156 4.323  1.00 72.62  ? 545  TYR A O     1 ? 
ATOM   4213 C CB    . TYR A 1 543 ? -1.400  -22.299 3.039  1.00 73.72  ? 545  TYR A CB    1 ? 
ATOM   4214 C CG    . TYR A 1 543 ? -0.132  -22.676 2.319  1.00 77.36  ? 545  TYR A CG    1 ? 
ATOM   4215 C CD1   . TYR A 1 543 ? 0.571   -21.741 1.577  1.00 86.35  ? 545  TYR A CD1   1 ? 
ATOM   4216 C CD2   . TYR A 1 543 ? 0.368   -23.966 2.384  1.00 80.91  ? 545  TYR A CD2   1 ? 
ATOM   4217 C CE1   . TYR A 1 543 ? 1.734   -22.083 0.900  1.00 93.93  ? 545  TYR A CE1   1 ? 
ATOM   4218 C CE2   . TYR A 1 543 ? 1.535   -24.320 1.729  1.00 82.45  ? 545  TYR A CE2   1 ? 
ATOM   4219 C CZ    . TYR A 1 543 ? 2.220   -23.380 0.974  1.00 91.98  ? 545  TYR A CZ    1 ? 
ATOM   4220 O OH    . TYR A 1 543 ? 3.382   -23.688 0.307  1.00 90.09  ? 545  TYR A OH    1 ? 
ATOM   4221 N N     . GLY A 1 544 ? -2.217  -19.767 5.590  1.00 65.93  ? 546  GLY A N     1 ? 
ATOM   4222 C CA    . GLY A 1 544 ? -3.326  -19.012 6.196  1.00 60.46  ? 546  GLY A CA    1 ? 
ATOM   4223 C C     . GLY A 1 544 ? -3.081  -18.670 7.656  1.00 61.22  ? 546  GLY A C     1 ? 
ATOM   4224 O O     . GLY A 1 544 ? -1.910  -18.535 8.069  1.00 63.13  ? 546  GLY A O     1 ? 
ATOM   4225 N N     . ALA A 1 545 ? -4.158  -18.500 8.408  1.00 56.06  ? 547  ALA A N     1 ? 
ATOM   4226 C CA    . ALA A 1 545 ? -4.106  -18.052 9.806  1.00 56.10  ? 547  ALA A CA    1 ? 
ATOM   4227 C C     . ALA A 1 545 ? -4.514  -19.199 10.720 1.00 57.11  ? 547  ALA A C     1 ? 
ATOM   4228 O O     . ALA A 1 545 ? -5.525  -19.884 10.434 1.00 57.84  ? 547  ALA A O     1 ? 
ATOM   4229 C CB    . ALA A 1 545 ? -4.987  -16.852 10.004 1.00 59.36  ? 547  ALA A CB    1 ? 
ATOM   4230 N N     . LEU A 1 546 ? -3.732  -19.398 11.774 1.00 58.21  ? 548  LEU A N     1 ? 
ATOM   4231 C CA    . LEU A 1 546 ? -3.920  -20.517 12.729 1.00 55.94  ? 548  LEU A CA    1 ? 
ATOM   4232 C C     . LEU A 1 546 ? -3.614  -20.019 14.138 1.00 57.59  ? 548  LEU A C     1 ? 
ATOM   4233 O O     . LEU A 1 546 ? -2.561  -19.420 14.377 1.00 58.08  ? 548  LEU A O     1 ? 
ATOM   4234 C CB    . LEU A 1 546 ? -3.031  -21.703 12.353 1.00 51.31  ? 548  LEU A CB    1 ? 
ATOM   4235 C CG    . LEU A 1 546 ? -3.003  -22.830 13.383 1.00 57.07  ? 548  LEU A CG    1 ? 
ATOM   4236 C CD1   . LEU A 1 546 ? -4.394  -23.397 13.614 1.00 63.68  ? 548  LEU A CD1   1 ? 
ATOM   4237 C CD2   . LEU A 1 546 ? -2.051  -23.928 12.946 1.00 57.58  ? 548  LEU A CD2   1 ? 
ATOM   4238 N N     . THR A 1 547 ? -4.536  -20.272 15.049 1.00 58.71  ? 549  THR A N     1 ? 
ATOM   4239 C CA    . THR A 1 547 ? -4.300  -20.112 16.500 1.00 52.33  ? 549  THR A CA    1 ? 
ATOM   4240 C C     . THR A 1 547 ? -4.244  -21.499 17.137 1.00 60.19  ? 549  THR A C     1 ? 
ATOM   4241 O O     . THR A 1 547 ? -5.202  -22.250 17.001 1.00 65.66  ? 549  THR A O     1 ? 
ATOM   4242 C CB    . THR A 1 547 ? -5.375  -19.257 17.149 1.00 52.76  ? 549  THR A CB    1 ? 
ATOM   4243 O OG1   . THR A 1 547 ? -5.398  -17.949 16.589 1.00 50.40  ? 549  THR A OG1   1 ? 
ATOM   4244 C CG2   . THR A 1 547 ? -5.130  -19.101 18.626 1.00 52.71  ? 549  THR A CG2   1 ? 
ATOM   4245 N N     . ILE A 1 548 ? -3.130  -21.812 17.784 1.00 59.21  ? 550  ILE A N     1 ? 
ATOM   4246 C CA    . ILE A 1 548 ? -2.985  -23.058 18.572 1.00 57.27  ? 550  ILE A CA    1 ? 
ATOM   4247 C C     . ILE A 1 548 ? -2.987  -22.690 20.053 1.00 58.40  ? 550  ILE A C     1 ? 
ATOM   4248 O O     . ILE A 1 548 ? -2.109  -21.921 20.480 1.00 57.64  ? 550  ILE A O     1 ? 
ATOM   4249 C CB    . ILE A 1 548 ? -1.714  -23.800 18.182 1.00 58.52  ? 550  ILE A CB    1 ? 
ATOM   4250 C CG1   . ILE A 1 548 ? -1.647  -24.001 16.675 1.00 61.02  ? 550  ILE A CG1   1 ? 
ATOM   4251 C CG2   . ILE A 1 548 ? -1.629  -25.111 18.929 1.00 60.58  ? 550  ILE A CG2   1 ? 
ATOM   4252 C CD1   . ILE A 1 548 ? -0.351  -24.592 16.217 1.00 60.35  ? 550  ILE A CD1   1 ? 
ATOM   4253 N N     . ARG A 1 549 ? -3.944  -23.230 20.791 1.00 61.25  ? 551  ARG A N     1 ? 
ATOM   4254 C CA    . ARG A 1 549 ? -4.089  -22.939 22.237 1.00 65.54  ? 551  ARG A CA    1 ? 
ATOM   4255 C C     . ARG A 1 549 ? -3.706  -24.170 23.042 1.00 62.72  ? 551  ARG A C     1 ? 
ATOM   4256 O O     . ARG A 1 549 ? -4.127  -25.274 22.716 1.00 74.27  ? 551  ARG A O     1 ? 
ATOM   4257 C CB    . ARG A 1 549 ? -5.519  -22.528 22.566 1.00 67.38  ? 551  ARG A CB    1 ? 
ATOM   4258 C CG    . ARG A 1 549 ? -5.940  -21.221 21.919 1.00 67.49  ? 551  ARG A CG    1 ? 
ATOM   4259 C CD    . ARG A 1 549 ? -7.107  -20.608 22.639 1.00 68.66  ? 551  ARG A CD    1 ? 
ATOM   4260 N NE    . ARG A 1 549 ? -7.430  -19.303 22.075 1.00 81.67  ? 551  ARG A NE    1 ? 
ATOM   4261 C CZ    . ARG A 1 549 ? -8.431  -19.062 21.229 1.00 82.23  ? 551  ARG A CZ    1 ? 
ATOM   4262 N NH1   . ARG A 1 549 ? -9.244  -20.030 20.840 1.00 75.15  ? 551  ARG A NH1   1 ? 
ATOM   4263 N NH2   . ARG A 1 549 ? -8.629  -17.832 20.791 1.00 86.68  ? 551  ARG A NH2   1 ? 
ATOM   4264 N N     . GLY A 1 550 ? -2.909  -23.969 24.063 1.00 65.68  ? 552  GLY A N     1 ? 
ATOM   4265 C CA    . GLY A 1 550 ? -2.498  -25.062 24.952 1.00 63.90  ? 552  GLY A CA    1 ? 
ATOM   4266 C C     . GLY A 1 550 ? -2.859  -24.722 26.384 1.00 62.04  ? 552  GLY A C     1 ? 
ATOM   4267 O O     . GLY A 1 550 ? -3.468  -23.690 26.650 1.00 61.87  ? 552  GLY A O     1 ? 
ATOM   4268 N N     . PRO A 1 551 ? -2.426  -25.560 27.338 1.00 71.26  ? 553  PRO A N     1 ? 
ATOM   4269 C CA    . PRO A 1 551 ? -2.706  -25.324 28.750 1.00 67.85  ? 553  PRO A CA    1 ? 
ATOM   4270 C C     . PRO A 1 551 ? -2.119  -24.003 29.256 1.00 76.29  ? 553  PRO A C     1 ? 
ATOM   4271 O O     . PRO A 1 551 ? -0.947  -23.707 29.011 1.00 73.03  ? 553  PRO A O     1 ? 
ATOM   4272 C CB    . PRO A 1 551 ? -2.019  -26.486 29.466 1.00 66.73  ? 553  PRO A CB    1 ? 
ATOM   4273 C CG    . PRO A 1 551 ? -1.902  -27.553 28.402 1.00 69.19  ? 553  PRO A CG    1 ? 
ATOM   4274 C CD    . PRO A 1 551 ? -1.674  -26.803 27.110 1.00 71.45  ? 553  PRO A CD    1 ? 
ATOM   4275 N N     . THR A 1 552 ? -2.940  -23.252 29.982 1.00 80.78  ? 554  THR A N     1 ? 
ATOM   4276 C CA    . THR A 1 552 ? -2.531  -21.944 30.539 1.00 81.49  ? 554  THR A CA    1 ? 
ATOM   4277 C C     . THR A 1 552 ? -1.455  -22.106 31.606 1.00 76.62  ? 554  THR A C     1 ? 
ATOM   4278 O O     . THR A 1 552 ? -0.713  -21.118 31.815 1.00 77.97  ? 554  THR A O     1 ? 
ATOM   4279 C CB    . THR A 1 552 ? -3.723  -21.195 31.125 1.00 85.00  ? 554  THR A CB    1 ? 
ATOM   4280 O OG1   . THR A 1 552 ? -4.638  -20.939 30.048 1.00 81.09  ? 554  THR A OG1   1 ? 
ATOM   4281 C CG2   . THR A 1 552 ? -3.306  -19.870 31.708 1.00 86.82  ? 554  THR A CG2   1 ? 
ATOM   4282 N N     . ASP A 1 553 ? -1.398  -23.267 32.259 1.00 76.17  ? 555  ASP A N     1 ? 
ATOM   4283 C CA    . ASP A 1 553 ? -0.382  -23.557 33.299 1.00 78.17  ? 555  ASP A CA    1 ? 
ATOM   4284 C C     . ASP A 1 553 ? 0.924   -24.004 32.631 1.00 76.38  ? 555  ASP A C     1 ? 
ATOM   4285 O O     . ASP A 1 553 ? 0.877   -24.855 31.726 1.00 73.52  ? 555  ASP A O     1 ? 
ATOM   4286 C CB    . ASP A 1 553 ? -0.881  -24.612 34.282 1.00 87.72  ? 555  ASP A CB    1 ? 
ATOM   4287 C CG    . ASP A 1 553 ? 0.046   -24.748 35.477 1.00 89.90  ? 555  ASP A CG    1 ? 
ATOM   4288 O OD1   . ASP A 1 553 ? 0.168   -23.766 36.225 1.00 82.01  ? 555  ASP A OD1   1 ? 
ATOM   4289 O OD2   . ASP A 1 553 ? 0.695   -25.813 35.604 1.00 99.31  ? 555  ASP A OD2   1 ? 
ATOM   4290 N N     . SER A 1 554 ? 2.051   -23.477 33.107 1.00 85.06  ? 556  SER A N     1 ? 
ATOM   4291 C CA    . SER A 1 554 ? 3.393   -23.751 32.526 1.00 87.87  ? 556  SER A CA    1 ? 
ATOM   4292 C C     . SER A 1 554 ? 3.812   -25.202 32.776 1.00 96.76  ? 556  SER A C     1 ? 
ATOM   4293 O O     . SER A 1 554 ? 4.398   -25.816 31.835 1.00 94.44  ? 556  SER A O     1 ? 
ATOM   4294 C CB    . SER A 1 554 ? 4.430   -22.819 33.076 1.00 85.16  ? 556  SER A CB    1 ? 
ATOM   4295 O OG    . SER A 1 554 ? 3.912   -21.517 33.255 1.00 90.28  ? 556  SER A OG    1 ? 
ATOM   4296 N N     . MET A 1 555 ? 3.561   -25.718 33.991 1.00 99.83  ? 557  MET A N     1 ? 
ATOM   4297 C CA    . MET A 1 555 ? 4.019   -27.076 34.396 1.00 94.67  ? 557  MET A CA    1 ? 
ATOM   4298 C C     . MET A 1 555 ? 3.006   -28.131 33.946 1.00 90.88  ? 557  MET A C     1 ? 
ATOM   4299 O O     . MET A 1 555 ? 3.287   -29.318 34.135 1.00 92.41  ? 557  MET A O     1 ? 
ATOM   4300 C CB    . MET A 1 555 ? 4.231   -27.168 35.908 1.00 94.53  ? 557  MET A CB    1 ? 
ATOM   4301 C CG    . MET A 1 555 ? 5.173   -26.099 36.443 1.00 102.67 ? 557  MET A CG    1 ? 
ATOM   4302 S SD    . MET A 1 555 ? 4.493   -25.210 37.874 1.00 122.23 ? 557  MET A SD    1 ? 
ATOM   4303 C CE    . MET A 1 555 ? 3.082   -24.384 37.135 1.00 113.43 ? 557  MET A CE    1 ? 
ATOM   4304 N N     . ALA A 1 556 ? 1.896   -27.736 33.324 1.00 85.83  ? 558  ALA A N     1 ? 
ATOM   4305 C CA    . ALA A 1 556 ? 0.943   -28.709 32.748 1.00 91.30  ? 558  ALA A CA    1 ? 
ATOM   4306 C C     . ALA A 1 556 ? 1.601   -29.418 31.568 1.00 84.41  ? 558  ALA A C     1 ? 
ATOM   4307 O O     . ALA A 1 556 ? 2.546   -28.859 30.978 1.00 90.34  ? 558  ALA A O     1 ? 
ATOM   4308 C CB    . ALA A 1 556 ? -0.343  -28.036 32.334 1.00 93.55  ? 558  ALA A CB    1 ? 
ATOM   4309 N N     . LEU A 1 557 ? 1.096   -30.602 31.240 1.00 91.25  ? 559  LEU A N     1 ? 
ATOM   4310 C CA    . LEU A 1 557 ? 1.591   -31.393 30.085 1.00 97.02  ? 559  LEU A CA    1 ? 
ATOM   4311 C C     . LEU A 1 557 ? 1.271   -30.671 28.781 1.00 95.60  ? 559  LEU A C     1 ? 
ATOM   4312 O O     . LEU A 1 557 ? 0.186   -30.110 28.596 1.00 96.38  ? 559  LEU A O     1 ? 
ATOM   4313 C CB    . LEU A 1 557 ? 0.957   -32.785 30.080 1.00 89.41  ? 559  LEU A CB    1 ? 
ATOM   4314 C CG    . LEU A 1 557 ? 1.324   -33.665 31.270 1.00 99.47  ? 559  LEU A CG    1 ? 
ATOM   4315 C CD1   . LEU A 1 557 ? 1.034   -35.121 30.941 1.00 101.86 ? 559  LEU A CD1   1 ? 
ATOM   4316 C CD2   . LEU A 1 557 ? 2.786   -33.478 31.680 1.00 92.41  ? 559  LEU A CD2   1 ? 
ATOM   4317 N N     . PRO A 1 558 ? 2.193   -30.718 27.803 1.00 79.54  ? 560  PRO A N     1 ? 
ATOM   4318 C CA    . PRO A 1 558 ? 2.067   -29.896 26.613 1.00 81.56  ? 560  PRO A CA    1 ? 
ATOM   4319 C C     . PRO A 1 558 ? 1.192   -30.527 25.532 1.00 81.19  ? 560  PRO A C     1 ? 
ATOM   4320 O O     . PRO A 1 558 ? 1.229   -31.725 25.370 1.00 86.67  ? 560  PRO A O     1 ? 
ATOM   4321 C CB    . PRO A 1 558 ? 3.510   -29.797 26.128 1.00 78.98  ? 560  PRO A CB    1 ? 
ATOM   4322 C CG    . PRO A 1 558 ? 4.114   -31.123 26.523 1.00 85.98  ? 560  PRO A CG    1 ? 
ATOM   4323 C CD    . PRO A 1 558 ? 3.409   -31.538 27.802 1.00 83.65  ? 560  PRO A CD    1 ? 
ATOM   4324 N N     . HIS A 1 559 ? 0.447   -29.679 24.829 1.00 81.60  ? 561  HIS A N     1 ? 
ATOM   4325 C CA    . HIS A 1 559 ? -0.284  -30.029 23.585 1.00 76.77  ? 561  HIS A CA    1 ? 
ATOM   4326 C C     . HIS A 1 559 ? 0.719   -30.135 22.438 1.00 74.80  ? 561  HIS A C     1 ? 
ATOM   4327 O O     . HIS A 1 559 ? 1.387   -29.137 22.151 1.00 86.70  ? 561  HIS A O     1 ? 
ATOM   4328 C CB    . HIS A 1 559 ? -1.360  -28.984 23.297 1.00 77.54  ? 561  HIS A CB    1 ? 
ATOM   4329 C CG    . HIS A 1 559 ? -2.061  -29.177 21.996 1.00 86.41  ? 561  HIS A CG    1 ? 
ATOM   4330 N ND1   . HIS A 1 559 ? -1.976  -30.352 21.281 1.00 96.99  ? 561  HIS A ND1   1 ? 
ATOM   4331 C CD2   . HIS A 1 559 ? -2.860  -28.352 21.280 1.00 85.68  ? 561  HIS A CD2   1 ? 
ATOM   4332 C CE1   . HIS A 1 559 ? -2.686  -30.243 20.174 1.00 91.18  ? 561  HIS A CE1   1 ? 
ATOM   4333 N NE2   . HIS A 1 559 ? -3.235  -29.018 20.145 1.00 82.43  ? 561  HIS A NE2   1 ? 
ATOM   4334 N N     . VAL A 1 560 ? 0.808   -31.299 21.810 1.00 67.34  ? 562  VAL A N     1 ? 
ATOM   4335 C CA    . VAL A 1 560 ? 1.781   -31.563 20.725 1.00 63.50  ? 562  VAL A CA    1 ? 
ATOM   4336 C C     . VAL A 1 560 ? 1.019   -31.586 19.409 1.00 73.43  ? 562  VAL A C     1 ? 
ATOM   4337 O O     . VAL A 1 560 ? -0.054  -32.218 19.343 1.00 75.97  ? 562  VAL A O     1 ? 
ATOM   4338 C CB    . VAL A 1 560 ? 2.556   -32.864 20.950 1.00 64.66  ? 562  VAL A CB    1 ? 
ATOM   4339 C CG1   . VAL A 1 560 ? 3.649   -33.028 19.914 1.00 61.35  ? 562  VAL A CG1   1 ? 
ATOM   4340 C CG2   . VAL A 1 560 ? 3.151   -32.916 22.341 1.00 64.00  ? 562  VAL A CG2   1 ? 
ATOM   4341 N N     . VAL A 1 561 ? 1.558   -30.899 18.409 1.00 68.70  ? 563  VAL A N     1 ? 
ATOM   4342 C CA    . VAL A 1 561 ? 0.922   -30.780 17.078 1.00 64.82  ? 563  VAL A CA    1 ? 
ATOM   4343 C C     . VAL A 1 561 ? 1.780   -31.536 16.083 1.00 73.07  ? 563  VAL A C     1 ? 
ATOM   4344 O O     . VAL A 1 561 ? 2.963   -31.167 15.904 1.00 66.64  ? 563  VAL A O     1 ? 
ATOM   4345 C CB    . VAL A 1 561 ? 0.754   -29.318 16.645 1.00 62.32  ? 563  VAL A CB    1 ? 
ATOM   4346 C CG1   . VAL A 1 561 ? 0.320   -29.237 15.193 1.00 61.23  ? 563  VAL A CG1   1 ? 
ATOM   4347 C CG2   . VAL A 1 561 ? -0.218  -28.590 17.549 1.00 62.27  ? 563  VAL A CG2   1 ? 
ATOM   4348 N N     . ARG A 1 562 ? 1.180   -32.538 15.439 1.00 80.75  ? 564  ARG A N     1 ? 
ATOM   4349 C CA    . ARG A 1 562 ? 1.919   -33.397 14.491 1.00 77.44  ? 564  ARG A CA    1 ? 
ATOM   4350 C C     . ARG A 1 562 ? 1.142   -33.441 13.176 1.00 74.84  ? 564  ARG A C     1 ? 
ATOM   4351 O O     . ARG A 1 562 ? -0.088  -33.521 13.194 1.00 77.22  ? 564  ARG A O     1 ? 
ATOM   4352 C CB    . ARG A 1 562 ? 2.157   -34.793 15.072 1.00 79.44  ? 564  ARG A CB    1 ? 
ATOM   4353 C CG    . ARG A 1 562 ? 2.578   -34.820 16.533 1.00 84.96  ? 564  ARG A CG    1 ? 
ATOM   4354 C CD    . ARG A 1 562 ? 2.816   -36.249 17.015 1.00 87.67  ? 564  ARG A CD    1 ? 
ATOM   4355 N NE    . ARG A 1 562 ? 3.229   -36.289 18.418 1.00 85.77  ? 564  ARG A NE    1 ? 
ATOM   4356 C CZ    . ARG A 1 562 ? 2.403   -36.455 19.452 1.00 87.59  ? 564  ARG A CZ    1 ? 
ATOM   4357 N NH1   . ARG A 1 562 ? 1.102   -36.634 19.259 1.00 87.97  ? 564  ARG A NH1   1 ? 
ATOM   4358 N NH2   . ARG A 1 562 ? 2.885   -36.444 20.683 1.00 83.69  ? 564  ARG A NH2   1 ? 
ATOM   4359 N N     . ASN A 1 563 ? 1.869   -33.365 12.069 1.00 78.33  ? 565  ASN A N     1 ? 
ATOM   4360 C CA    . ASN A 1 563 ? 1.355   -33.632 10.702 1.00 82.46  ? 565  ASN A CA    1 ? 
ATOM   4361 C C     . ASN A 1 563 ? 0.113   -32.786 10.421 1.00 80.72  ? 565  ASN A C     1 ? 
ATOM   4362 O O     . ASN A 1 563 ? -0.729  -33.244 9.630  1.00 82.97  ? 565  ASN A O     1 ? 
ATOM   4363 C CB    . ASN A 1 563 ? 1.020   -35.114 10.510 1.00 80.32  ? 565  ASN A CB    1 ? 
ATOM   4364 C CG    . ASN A 1 563 ? 2.173   -36.021 10.883 1.00 79.18  ? 565  ASN A CG    1 ? 
ATOM   4365 O OD1   . ASN A 1 563 ? 3.222   -35.995 10.249 1.00 76.04  ? 565  ASN A OD1   1 ? 
ATOM   4366 N ND2   . ASN A 1 563 ? 1.991   -36.817 11.923 1.00 80.01  ? 565  ASN A ND2   1 ? 
ATOM   4367 N N     . ALA A 1 564 ? 0.012   -31.598 11.014 1.00 72.44  ? 566  ALA A N     1 ? 
ATOM   4368 C CA    . ALA A 1 564 ? -1.149  -30.708 10.790 1.00 71.21  ? 566  ALA A CA    1 ? 
ATOM   4369 C C     . ALA A 1 564 ? -0.998  -29.998 9.450  1.00 64.65  ? 566  ALA A C     1 ? 
ATOM   4370 O O     . ALA A 1 564 ? 0.118   -29.635 9.097  1.00 73.97  ? 566  ALA A O     1 ? 
ATOM   4371 C CB    . ALA A 1 564 ? -1.302  -29.727 11.916 1.00 69.56  ? 566  ALA A CB    1 ? 
ATOM   4372 N N     . VAL A 1 565 ? -2.103  -29.852 8.733  1.00 65.89  ? 567  VAL A N     1 ? 
ATOM   4373 C CA    . VAL A 1 565 ? -2.181  -29.069 7.469  1.00 61.66  ? 567  VAL A CA    1 ? 
ATOM   4374 C C     . VAL A 1 565 ? -3.371  -28.130 7.600  1.00 63.96  ? 567  VAL A C     1 ? 
ATOM   4375 O O     . VAL A 1 565 ? -4.483  -28.612 7.823  1.00 72.15  ? 567  VAL A O     1 ? 
ATOM   4376 C CB    . VAL A 1 565 ? -2.330  -29.990 6.249  1.00 64.16  ? 567  VAL A CB    1 ? 
ATOM   4377 C CG1   . VAL A 1 565 ? -2.582  -29.183 4.981  1.00 65.59  ? 567  VAL A CG1   1 ? 
ATOM   4378 C CG2   . VAL A 1 565 ? -1.106  -30.882 6.087  1.00 60.62  ? 567  VAL A CG2   1 ? 
ATOM   4379 N N     . VAL A 1 566 ? -3.128  -26.832 7.499  1.00 61.44  ? 568  VAL A N     1 ? 
ATOM   4380 C CA    . VAL A 1 566 ? -4.193  -25.800 7.624  1.00 63.09  ? 568  VAL A CA    1 ? 
ATOM   4381 C C     . VAL A 1 566 ? -4.134  -24.880 6.417  1.00 59.70  ? 568  VAL A C     1 ? 
ATOM   4382 O O     . VAL A 1 566 ? -3.058  -24.363 6.125  1.00 65.02  ? 568  VAL A O     1 ? 
ATOM   4383 C CB    . VAL A 1 566 ? -4.046  -25.001 8.926  1.00 64.94  ? 568  VAL A CB    1 ? 
ATOM   4384 C CG1   . VAL A 1 566 ? -5.206  -24.029 9.092  1.00 62.82  ? 568  VAL A CG1   1 ? 
ATOM   4385 C CG2   . VAL A 1 566 ? -3.943  -25.932 10.125 1.00 64.09  ? 568  VAL A CG2   1 ? 
ATOM   4386 N N     . ARG A 1 567 ? -5.272  -24.680 5.771  1.00 68.71  ? 569  ARG A N     1 ? 
ATOM   4387 C CA    . ARG A 1 567 ? -5.377  -23.787 4.598  1.00 70.42  ? 569  ARG A CA    1 ? 
ATOM   4388 C C     . ARG A 1 567 ? -6.641  -22.961 4.742  1.00 68.36  ? 569  ARG A C     1 ? 
ATOM   4389 O O     . ARG A 1 567 ? -7.730  -23.548 4.893  1.00 65.73  ? 569  ARG A O     1 ? 
ATOM   4390 C CB    . ARG A 1 567 ? -5.425  -24.579 3.293  1.00 76.55  ? 569  ARG A CB    1 ? 
ATOM   4391 C CG    . ARG A 1 567 ? -4.223  -25.478 3.060  1.00 77.22  ? 569  ARG A CG    1 ? 
ATOM   4392 C CD    . ARG A 1 567 ? -4.255  -26.044 1.653  1.00 81.98  ? 569  ARG A CD    1 ? 
ATOM   4393 N NE    . ARG A 1 567 ? -3.506  -27.292 1.547  1.00 90.38  ? 569  ARG A NE    1 ? 
ATOM   4394 C CZ    . ARG A 1 567 ? -2.412  -27.459 0.806  1.00 101.69 ? 569  ARG A CZ    1 ? 
ATOM   4395 N NH1   . ARG A 1 567 ? -1.941  -26.465 0.073  1.00 101.42 ? 569  ARG A NH1   1 ? 
ATOM   4396 N NH2   . ARG A 1 567 ? -1.792  -28.627 0.788  1.00 103.56 ? 569  ARG A NH2   1 ? 
ATOM   4397 N N     . ASN A 1 568 ? -6.486  -21.644 4.705  1.00 60.38  ? 570  ASN A N     1 ? 
ATOM   4398 C CA    . ASN A 1 568 ? -7.655  -20.733 4.746  1.00 58.92  ? 570  ASN A CA    1 ? 
ATOM   4399 C C     . ASN A 1 568 ? -7.241  -19.391 4.170  1.00 53.84  ? 570  ASN A C     1 ? 
ATOM   4400 O O     . ASN A 1 568 ? -6.071  -19.194 3.846  1.00 52.23  ? 570  ASN A O     1 ? 
ATOM   4401 C CB    . ASN A 1 568 ? -8.208  -20.634 6.174  1.00 59.91  ? 570  ASN A CB    1 ? 
ATOM   4402 C CG    . ASN A 1 568 ? -7.138  -20.206 7.156  1.00 62.20  ? 570  ASN A CG    1 ? 
ATOM   4403 O OD1   . ASN A 1 568 ? -6.537  -19.144 6.996  1.00 63.03  ? 570  ASN A OD1   1 ? 
ATOM   4404 N ND2   . ASN A 1 568 ? -6.890  -21.027 8.165  1.00 63.21  ? 570  ASN A ND2   1 ? 
ATOM   4405 N N     . ALA A 1 569 ? -8.187  -18.474 4.088  1.00 58.62  ? 571  ALA A N     1 ? 
ATOM   4406 C CA    . ALA A 1 569 ? -7.954  -17.115 3.531  1.00 58.82  ? 571  ALA A CA    1 ? 
ATOM   4407 C C     . ALA A 1 569 ? -6.965  -16.319 4.394  1.00 60.60  ? 571  ALA A C     1 ? 
ATOM   4408 O O     . ALA A 1 569 ? -6.349  -15.374 3.863  1.00 55.61  ? 571  ALA A O     1 ? 
ATOM   4409 C CB    . ALA A 1 569 ? -9.272  -16.388 3.428  1.00 58.72  ? 571  ALA A CB    1 ? 
ATOM   4410 N N     . GLY A 1 570 ? -6.858  -16.641 5.692  1.00 63.64  ? 572  GLY A N     1 ? 
ATOM   4411 C CA    . GLY A 1 570 ? -5.884  -15.964 6.570  1.00 59.48  ? 572  GLY A CA    1 ? 
ATOM   4412 C C     . GLY A 1 570 ? -6.143  -14.467 6.633  1.00 56.11  ? 572  GLY A C     1 ? 
ATOM   4413 O O     . GLY A 1 570 ? -7.293  -14.055 6.573  1.00 64.53  ? 572  GLY A O     1 ? 
ATOM   4414 N N     . TRP A 1 571 ? -5.087  -13.694 6.784  1.00 52.67  ? 573  TRP A N     1 ? 
ATOM   4415 C CA    . TRP A 1 571 ? -5.173  -12.263 7.130  1.00 56.17  ? 573  TRP A CA    1 ? 
ATOM   4416 C C     . TRP A 1 571 ? -4.583  -11.456 5.990  1.00 55.74  ? 573  TRP A C     1 ? 
ATOM   4417 O O     . TRP A 1 571 ? -3.774  -11.982 5.237  1.00 60.41  ? 573  TRP A O     1 ? 
ATOM   4418 C CB    . TRP A 1 571 ? -4.424  -11.929 8.435  1.00 56.52  ? 573  TRP A CB    1 ? 
ATOM   4419 C CG    . TRP A 1 571 ? -5.061  -12.450 9.675  1.00 54.55  ? 573  TRP A CG    1 ? 
ATOM   4420 C CD1   . TRP A 1 571 ? -6.131  -13.285 9.760  1.00 53.99  ? 573  TRP A CD1   1 ? 
ATOM   4421 C CD2   . TRP A 1 571 ? -4.614  -12.219 11.021 1.00 53.50  ? 573  TRP A CD2   1 ? 
ATOM   4422 N NE1   . TRP A 1 571 ? -6.407  -13.554 11.072 1.00 57.86  ? 573  TRP A NE1   1 ? 
ATOM   4423 C CE2   . TRP A 1 571 ? -5.488  -12.924 11.868 1.00 54.63  ? 573  TRP A CE2   1 ? 
ATOM   4424 C CE3   . TRP A 1 571 ? -3.590  -11.464 11.593 1.00 53.69  ? 573  TRP A CE3   1 ? 
ATOM   4425 C CZ2   . TRP A 1 571 ? -5.365  -12.897 13.249 1.00 57.80  ? 573  TRP A CZ2   1 ? 
ATOM   4426 C CZ3   . TRP A 1 571 ? -3.470  -11.433 12.971 1.00 56.07  ? 573  TRP A CZ3   1 ? 
ATOM   4427 C CH2   . TRP A 1 571 ? -4.351  -12.135 13.780 1.00 56.43  ? 573  TRP A CH2   1 ? 
ATOM   4428 N N     . SER A 1 572 ? -4.945  -10.183 5.949  1.00 58.64  ? 574  SER A N     1 ? 
ATOM   4429 C CA    . SER A 1 572 ? -4.305  -9.199  5.049  1.00 57.49  ? 574  SER A CA    1 ? 
ATOM   4430 C C     . SER A 1 572 ? -4.043  -7.915  5.822  1.00 62.51  ? 574  SER A C     1 ? 
ATOM   4431 O O     . SER A 1 572 ? -4.493  -7.779  6.966  1.00 62.80  ? 574  SER A O     1 ? 
ATOM   4432 C CB    . SER A 1 572 ? -5.126  -8.939  3.794  1.00 57.99  ? 574  SER A CB    1 ? 
ATOM   4433 O OG    . SER A 1 572 ? -6.477  -8.614  4.060  1.00 63.56  ? 574  SER A OG    1 ? 
ATOM   4434 N N     . VAL A 1 573 ? -3.334  -7.000  5.185  1.00 58.30  ? 575  VAL A N     1 ? 
ATOM   4435 C CA    . VAL A 1 573 ? -3.159  -5.648  5.753  1.00 58.99  ? 575  VAL A CA    1 ? 
ATOM   4436 C C     . VAL A 1 573 ? -3.470  -4.632  4.664  1.00 58.36  ? 575  VAL A C     1 ? 
ATOM   4437 O O     . VAL A 1 573 ? -3.106  -4.856  3.518  1.00 59.91  ? 575  VAL A O     1 ? 
ATOM   4438 C CB    . VAL A 1 573 ? -1.745  -5.491  6.323  1.00 56.77  ? 575  VAL A CB    1 ? 
ATOM   4439 C CG1   . VAL A 1 573 ? -0.693  -5.765  5.252  1.00 58.97  ? 575  VAL A CG1   1 ? 
ATOM   4440 C CG2   . VAL A 1 573 ? -1.554  -4.120  6.954  1.00 54.13  ? 575  VAL A CG2   1 ? 
ATOM   4441 N N     . HIS A 1 574 ? -4.152  -3.555  5.023  1.00 65.82  ? 576  HIS A N     1 ? 
ATOM   4442 C CA    . HIS A 1 574 ? -4.373  -2.443  4.074  1.00 65.73  ? 576  HIS A CA    1 ? 
ATOM   4443 C C     . HIS A 1 574 ? -4.203  -1.122  4.800  1.00 64.99  ? 576  HIS A C     1 ? 
ATOM   4444 O O     . HIS A 1 574 ? -4.507  -1.050  6.009  1.00 63.03  ? 576  HIS A O     1 ? 
ATOM   4445 C CB    . HIS A 1 574 ? -5.716  -2.560  3.351  1.00 66.07  ? 576  HIS A CB    1 ? 
ATOM   4446 C CG    . HIS A 1 574 ? -6.899  -2.339  4.218  1.00 78.53  ? 576  HIS A CG    1 ? 
ATOM   4447 N ND1   . HIS A 1 574 ? -7.429  -1.079  4.441  1.00 99.32  ? 576  HIS A ND1   1 ? 
ATOM   4448 C CD2   . HIS A 1 574 ? -7.667  -3.206  4.918  1.00 89.83  ? 576  HIS A CD2   1 ? 
ATOM   4449 C CE1   . HIS A 1 574 ? -8.471  -1.180  5.263  1.00 97.12  ? 576  HIS A CE1   1 ? 
ATOM   4450 N NE2   . HIS A 1 574 ? -8.648  -2.486  5.571  1.00 93.61  ? 576  HIS A NE2   1 ? 
ATOM   4451 N N     . ALA A 1 575 ? -3.728  -0.122  4.061  1.00 56.34  ? 577  ALA A N     1 ? 
ATOM   4452 C CA    . ALA A 1 575 ? -3.468  1.215   4.615  1.00 58.58  ? 577  ALA A CA    1 ? 
ATOM   4453 C C     . ALA A 1 575 ? -4.788  1.917   4.904  1.00 55.45  ? 577  ALA A C     1 ? 
ATOM   4454 O O     . ALA A 1 575 ? -5.837  1.568   4.349  1.00 55.18  ? 577  ALA A O     1 ? 
ATOM   4455 C CB    . ALA A 1 575 ? -2.595  2.019   3.685  1.00 59.51  ? 577  ALA A CB    1 ? 
ATOM   4456 N N     . ILE A 1 576 ? -4.722  2.882   5.794  1.00 60.01  ? 578  ILE A N     1 ? 
ATOM   4457 C CA    . ILE A 1 576 ? -5.885  3.755   6.083  1.00 72.12  ? 578  ILE A CA    1 ? 
ATOM   4458 C C     . ILE A 1 576 ? -5.913  4.803   4.983  1.00 70.63  ? 578  ILE A C     1 ? 
ATOM   4459 O O     . ILE A 1 576 ? -4.938  5.575   4.882  1.00 63.45  ? 578  ILE A O     1 ? 
ATOM   4460 C CB    . ILE A 1 576 ? -5.790  4.382   7.482  1.00 69.07  ? 578  ILE A CB    1 ? 
ATOM   4461 C CG1   . ILE A 1 576 ? -5.669  3.290   8.548  1.00 68.94  ? 578  ILE A CG1   1 ? 
ATOM   4462 C CG2   . ILE A 1 576 ? -6.993  5.275   7.724  1.00 68.36  ? 578  ILE A CG2   1 ? 
ATOM   4463 C CD1   . ILE A 1 576 ? -5.529  3.829   9.963  1.00 70.96  ? 578  ILE A CD1   1 ? 
ATOM   4464 N N     . LEU A 1 577 ? -6.971  4.790   4.179  1.00 84.29  ? 579  LEU A N     1 ? 
ATOM   4465 C CA    . LEU A 1 577 ? -7.107  5.730   3.044  1.00 84.36  ? 579  LEU A CA    1 ? 
ATOM   4466 C C     . LEU A 1 577 ? -7.341  7.130   3.597  1.00 91.21  ? 579  LEU A C     1 ? 
ATOM   4467 O O     . LEU A 1 577 ? -8.022  7.260   4.652  1.00 97.51  ? 579  LEU A O     1 ? 
ATOM   4468 C CB    . LEU A 1 577 ? -8.263  5.292   2.144  1.00 84.32  ? 579  LEU A CB    1 ? 
ATOM   4469 C CG    . LEU A 1 577 ? -8.082  3.931   1.478  1.00 87.88  ? 579  LEU A CG    1 ? 
ATOM   4470 C CD1   . LEU A 1 577 ? -9.302  3.569   0.640  1.00 85.92  ? 579  LEU A CD1   1 ? 
ATOM   4471 C CD2   . LEU A 1 577 ? -6.822  3.913   0.624  1.00 87.97  ? 579  LEU A CD2   1 ? 
ATOM   4472 N N     . SER A 1 578 ? -6.792  8.129   2.912  1.00 94.74  ? 580  SER A N     1 ? 
ATOM   4473 C CA    . SER A 1 578 ? -7.053  9.555   3.228  1.00 109.21 ? 580  SER A CA    1 ? 
ATOM   4474 C C     . SER A 1 578 ? -8.532  9.876   2.963  1.00 110.49 ? 580  SER A C     1 ? 
ATOM   4475 O O     . SER A 1 578 ? -9.084  10.727  3.676  1.00 114.40 ? 580  SER A O     1 ? 
ATOM   4476 C CB    . SER A 1 578 ? -6.152  10.456  2.432  1.00 107.79 ? 580  SER A CB    1 ? 
ATOM   4477 O OG    . SER A 1 578 ? -4.790  10.069  2.529  1.00 100.67 ? 580  SER A OG    1 ? 
ATOM   4478 N N     . LEU A 1 579 ? -9.146  9.198   1.989  1.00 123.34 ? 581  LEU A N     1 ? 
ATOM   4479 C CA    . LEU A 1 579 ? -10.554 9.433   1.570  1.00 135.15 ? 581  LEU A CA    1 ? 
ATOM   4480 C C     . LEU A 1 579 ? -11.529 8.690   2.491  1.00 140.21 ? 581  LEU A C     1 ? 
ATOM   4481 O O     . LEU A 1 579 ? -12.694 8.474   2.076  1.00 134.18 ? 581  LEU A O     1 ? 
ATOM   4482 C CB    . LEU A 1 579 ? -10.726 8.965   0.123  1.00 140.30 ? 581  LEU A CB    1 ? 
ATOM   4483 C CG    . LEU A 1 579 ? -11.891 9.587   -0.646 1.00 144.30 ? 581  LEU A CG    1 ? 
ATOM   4484 C CD1   . LEU A 1 579 ? -11.843 11.112  -0.601 1.00 140.65 ? 581  LEU A CD1   1 ? 
ATOM   4485 C CD2   . LEU A 1 579 ? -11.876 9.097   -2.078 1.00 142.70 ? 581  LEU A CD2   1 ? 
ATOM   4486 N N     . CYS A 1 580 ? -11.082 8.286   3.679  1.00 144.01 ? 582  CYS A N     1 ? 
ATOM   4487 C CA    . CYS A 1 580 ? -11.986 7.684   4.690  1.00 147.71 ? 582  CYS A CA    1 ? 
ATOM   4488 C C     . CYS A 1 580 ? -13.068 8.699   5.068  1.00 152.74 ? 582  CYS A C     1 ? 
ATOM   4489 O O     . CYS A 1 580 ? -12.715 9.876   5.319  1.00 152.89 ? 582  CYS A O     1 ? 
ATOM   4490 C CB    . CYS A 1 580 ? -11.218 7.205   5.918  1.00 144.84 ? 582  CYS A CB    1 ? 
ATOM   4491 S SG    . CYS A 1 580 ? -10.216 8.454   6.774  1.00 142.59 ? 582  CYS A SG    1 ? 
ATOM   4492 N N     . ALA A 1 581 ? -14.333 8.268   5.082  0.50 157.87 ? 583  ALA A N     1 ? 
ATOM   4493 C CA    . ALA A 1 581 ? -15.485 9.144   5.398  0.50 156.63 ? 583  ALA A CA    1 ? 
ATOM   4494 C C     . ALA A 1 581 ? -15.432 9.530   6.879  0.50 158.04 ? 583  ALA A C     1 ? 
ATOM   4495 O O     . ALA A 1 581 ? -15.672 10.717  7.178  0.50 157.93 ? 583  ALA A O     1 ? 
ATOM   4496 C CB    . ALA A 1 581 ? -16.787 8.475   5.047  0.50 145.04 ? 583  ALA A CB    1 ? 
ATOM   4497 N N     . GLY A 1 582 ? -15.129 8.569   7.760  0.50 155.73 ? 584  GLY A N     1 ? 
ATOM   4498 C CA    . GLY A 1 582 ? -14.987 8.826   9.204  0.50 152.73 ? 584  GLY A CA    1 ? 
ATOM   4499 C C     . GLY A 1 582 ? -16.269 8.550   9.970  0.50 155.25 ? 584  GLY A C     1 ? 
ATOM   4500 O O     . GLY A 1 582 ? -16.184 8.517   11.217 0.50 159.42 ? 584  GLY A O     1 ? 
ATOM   4501 N N     . ARG A 1 583 ? -17.417 8.371   9.297  0.50 156.97 ? 585  ARG A N     1 ? 
ATOM   4502 C CA    . ARG A 1 583 ? -18.662 7.965   10.014 0.50 156.73 ? 585  ARG A CA    1 ? 
ATOM   4503 C C     . ARG A 1 583 ? -18.608 6.445   10.222 0.50 157.72 ? 585  ARG A C     1 ? 
ATOM   4504 O O     . ARG A 1 583 ? -18.093 5.764   9.299  0.50 157.48 ? 585  ARG A O     1 ? 
ATOM   4505 C CB    . ARG A 1 583 ? -19.919 8.356   9.238  0.50 154.33 ? 585  ARG A CB    1 ? 
ATOM   4506 C CG    . ARG A 1 583 ? -21.153 8.508   10.117 0.50 151.03 ? 585  ARG A CG    1 ? 
ATOM   4507 C CD    . ARG A 1 583 ? -22.436 8.300   9.336  0.50 149.39 ? 585  ARG A CD    1 ? 
ATOM   4508 N NE    . ARG A 1 583 ? -22.434 7.030   8.618  0.50 156.58 ? 585  ARG A NE    1 ? 
ATOM   4509 C CZ    . ARG A 1 583 ? -22.682 5.842   9.170  0.50 159.43 ? 585  ARG A CZ    1 ? 
ATOM   4510 N NH1   . ARG A 1 583 ? -22.969 5.752   10.459 0.50 162.59 ? 585  ARG A NH1   1 ? 
ATOM   4511 N NH2   . ARG A 1 583 ? -22.642 4.744   8.431  0.50 156.26 ? 585  ARG A NH2   1 ? 
ATOM   4512 N N     . ASP A 1 584 ? -19.119 5.927   11.353 1.00 151.91 ? 586  ASP A N     1 ? 
ATOM   4513 C CA    . ASP A 1 584 ? -18.978 4.493   11.758 1.00 145.55 ? 586  ASP A CA    1 ? 
ATOM   4514 C C     . ASP A 1 584 ? -17.490 4.122   11.757 1.00 147.78 ? 586  ASP A C     1 ? 
ATOM   4515 O O     . ASP A 1 584 ? -17.158 2.980   11.340 1.00 142.96 ? 586  ASP A O     1 ? 
ATOM   4516 C CB    . ASP A 1 584 ? -19.753 3.529   10.842 1.00 134.81 ? 586  ASP A CB    1 ? 
ATOM   4517 C CG    . ASP A 1 584 ? -19.915 2.110   11.394 1.00 117.13 ? 586  ASP A CG    1 ? 
ATOM   4518 O OD1   . ASP A 1 584 ? -19.264 1.780   12.403 1.00 118.55 ? 586  ASP A OD1   1 ? 
ATOM   4519 O OD2   . ASP A 1 584 ? -20.697 1.333   10.822 1.00 105.27 ? 586  ASP A OD2   1 ? 
ATOM   4520 N N     . SER A 1 585 ? -16.617 5.041   12.193 1.00 132.58 ? 587  SER A N     1 ? 
ATOM   4521 C CA    . SER A 1 585 ? -15.157 4.797   12.128 1.00 119.94 ? 587  SER A CA    1 ? 
ATOM   4522 C C     . SER A 1 585 ? -14.854 3.768   13.208 1.00 123.32 ? 587  SER A C     1 ? 
ATOM   4523 O O     . SER A 1 585 ? -14.890 4.147   14.405 1.00 119.65 ? 587  SER A O     1 ? 
ATOM   4524 C CB    . SER A 1 585 ? -14.339 6.051   12.275 1.00 110.65 ? 587  SER A CB    1 ? 
ATOM   4525 O OG    . SER A 1 585 ? -14.296 6.522   13.613 1.00 108.52 ? 587  SER A OG    1 ? 
ATOM   4526 N N     . ARG A 1 586 ? -14.643 2.509   12.809 1.00 109.52 ? 588  ARG A N     1 ? 
ATOM   4527 C CA    . ARG A 1 586 ? -14.090 1.504   13.758 1.00 105.38 ? 588  ARG A CA    1 ? 
ATOM   4528 C C     . ARG A 1 586 ? -12.583 1.755   13.842 1.00 96.38  ? 588  ARG A C     1 ? 
ATOM   4529 O O     . ARG A 1 586 ? -11.904 1.051   14.609 1.00 94.65  ? 588  ARG A O     1 ? 
ATOM   4530 C CB    . ARG A 1 586 ? -14.436 0.085   13.313 1.00 112.11 ? 588  ARG A CB    1 ? 
ATOM   4531 C CG    . ARG A 1 586 ? -15.685 -0.480  13.971 1.00 113.51 ? 588  ARG A CG    1 ? 
ATOM   4532 C CD    . ARG A 1 586 ? -15.310 -1.315  15.182 1.00 117.23 ? 588  ARG A CD    1 ? 
ATOM   4533 N NE    . ARG A 1 586 ? -15.783 -2.685  15.050 1.00 115.02 ? 588  ARG A NE    1 ? 
ATOM   4534 C CZ    . ARG A 1 586 ? -15.474 -3.672  15.883 1.00 108.95 ? 588  ARG A CZ    1 ? 
ATOM   4535 N NH1   . ARG A 1 586 ? -14.688 -3.446  16.925 1.00 98.58  ? 588  ARG A NH1   1 ? 
ATOM   4536 N NH2   . ARG A 1 586 ? -15.954 -4.887  15.668 1.00 91.33  ? 588  ARG A NH2   1 ? 
ATOM   4537 N N     . LEU A 1 587 ? -12.097 2.763   13.105 1.00 91.58  ? 589  LEU A N     1 ? 
ATOM   4538 C CA    . LEU A 1 587 ? -10.668 3.176   13.112 1.00 86.22  ? 589  LEU A CA    1 ? 
ATOM   4539 C C     . LEU A 1 587 ? -10.370 4.001   14.361 1.00 77.73  ? 589  LEU A C     1 ? 
ATOM   4540 O O     . LEU A 1 587 ? -10.741 5.172   14.415 1.00 81.06  ? 589  LEU A O     1 ? 
ATOM   4541 C CB    . LEU A 1 587 ? -10.365 3.981   11.848 1.00 81.85  ? 589  LEU A CB    1 ? 
ATOM   4542 C CG    . LEU A 1 587 ? -10.271 3.156   10.567 1.00 76.73  ? 589  LEU A CG    1 ? 
ATOM   4543 C CD1   . LEU A 1 587 ? -10.376 4.052   9.350  1.00 77.91  ? 589  LEU A CD1   1 ? 
ATOM   4544 C CD2   . LEU A 1 587 ? -8.978  2.378   10.537 1.00 81.59  ? 589  LEU A CD2   1 ? 
ATOM   4545 N N     . SER A 1 588 ? -9.704  3.389   15.325 1.00 78.46  ? 590  SER A N     1 ? 
ATOM   4546 C CA    . SER A 1 588 ? -9.251  4.068   16.563 1.00 65.16  ? 590  SER A CA    1 ? 
ATOM   4547 C C     . SER A 1 588 ? -7.924  4.778   16.311 1.00 58.32  ? 590  SER A C     1 ? 
ATOM   4548 O O     . SER A 1 588 ? -7.344  4.636   15.209 1.00 61.57  ? 590  SER A O     1 ? 
ATOM   4549 C CB    . SER A 1 588 ? -9.119  3.063   17.676 1.00 69.10  ? 590  SER A CB    1 ? 
ATOM   4550 O OG    . SER A 1 588 ? -8.345  1.940   17.240 1.00 66.60  ? 590  SER A OG    1 ? 
ATOM   4551 N N     . GLU A 1 589 ? -7.454  5.500   17.319 1.00 55.54  ? 591  GLU A N     1 ? 
ATOM   4552 C CA    . GLU A 1 589 ? -6.151  6.186   17.245 1.00 63.21  ? 591  GLU A CA    1 ? 
ATOM   4553 C C     . GLU A 1 589 ? -5.016  5.162   17.270 1.00 60.78  ? 591  GLU A C     1 ? 
ATOM   4554 O O     . GLU A 1 589 ? -3.941  5.484   16.761 1.00 65.65  ? 591  GLU A O     1 ? 
ATOM   4555 C CB    . GLU A 1 589 ? -6.016  7.254   18.329 1.00 66.21  ? 591  GLU A CB    1 ? 
ATOM   4556 C CG    . GLU A 1 589 ? -6.351  6.792   19.727 1.00 82.63  ? 591  GLU A CG    1 ? 
ATOM   4557 C CD    . GLU A 1 589 ? -6.158  7.868   20.789 1.00 82.19  ? 591  GLU A CD    1 ? 
ATOM   4558 O OE1   . GLU A 1 589 ? -5.925  9.046   20.433 1.00 73.96  ? 591  GLU A OE1   1 ? 
ATOM   4559 O OE2   . GLU A 1 589 ? -6.226  7.517   21.980 1.00 81.37  ? 591  GLU A OE2   1 ? 
ATOM   4560 N N     . VAL A 1 590 ? -5.257  3.958   17.766 1.00 60.84  ? 592  VAL A N     1 ? 
ATOM   4561 C CA    . VAL A 1 590 ? -4.246  2.866   17.711 1.00 63.20  ? 592  VAL A CA    1 ? 
ATOM   4562 C C     . VAL A 1 590 ? -4.009  2.450   16.257 1.00 54.51  ? 592  VAL A C     1 ? 
ATOM   4563 O O     . VAL A 1 590 ? -2.852  2.192   15.893 1.00 51.27  ? 592  VAL A O     1 ? 
ATOM   4564 C CB    . VAL A 1 590 ? -4.677  1.660   18.561 1.00 62.95  ? 592  VAL A CB    1 ? 
ATOM   4565 C CG1   . VAL A 1 590 ? -3.851  0.442   18.254 1.00 60.22  ? 592  VAL A CG1   1 ? 
ATOM   4566 C CG2   . VAL A 1 590 ? -4.590  1.981   20.031 1.00 67.85  ? 592  VAL A CG2   1 ? 
ATOM   4567 N N     . ASP A 1 591 ? -5.076  2.354   15.476 1.00 57.60  ? 593  ASP A N     1 ? 
ATOM   4568 C CA    . ASP A 1 591 ? -4.956  2.089   14.025 1.00 59.90  ? 593  ASP A CA    1 ? 
ATOM   4569 C C     . ASP A 1 591 ? -4.336  3.294   13.331 1.00 58.57  ? 593  ASP A C     1 ? 
ATOM   4570 O O     . ASP A 1 591 ? -3.446  3.093   12.514 1.00 59.29  ? 593  ASP A O     1 ? 
ATOM   4571 C CB    . ASP A 1 591 ? -6.305  1.782   13.407 1.00 56.55  ? 593  ASP A CB    1 ? 
ATOM   4572 C CG    . ASP A 1 591 ? -6.996  0.638   14.095 1.00 62.55  ? 593  ASP A CG    1 ? 
ATOM   4573 O OD1   . ASP A 1 591 ? -6.369  -0.438  14.194 1.00 68.51  ? 593  ASP A OD1   1 ? 
ATOM   4574 O OD2   . ASP A 1 591 ? -8.158  0.852   14.528 1.00 72.52  ? 593  ASP A OD2   1 ? 
ATOM   4575 N N     . ARG A 1 592 ? -4.754  4.494   13.707 1.00 59.12  ? 594  ARG A N     1 ? 
ATOM   4576 C CA    . ARG A 1 592 ? -4.420  5.711   12.936 1.00 59.65  ? 594  ARG A CA    1 ? 
ATOM   4577 C C     . ARG A 1 592 ? -2.939  6.049   13.065 1.00 56.95  ? 594  ARG A C     1 ? 
ATOM   4578 O O     . ARG A 1 592 ? -2.391  6.612   12.122 1.00 71.57  ? 594  ARG A O     1 ? 
ATOM   4579 C CB    . ARG A 1 592 ? -5.321  6.867   13.371 1.00 65.54  ? 594  ARG A CB    1 ? 
ATOM   4580 C CG    . ARG A 1 592 ? -6.425  7.176   12.377 1.00 67.57  ? 594  ARG A CG    1 ? 
ATOM   4581 C CD    . ARG A 1 592 ? -7.197  8.410   12.779 1.00 69.84  ? 594  ARG A CD    1 ? 
ATOM   4582 N NE    . ARG A 1 592 ? -8.624  8.142   12.826 1.00 81.18  ? 594  ARG A NE    1 ? 
ATOM   4583 C CZ    . ARG A 1 592 ? -9.426  8.064   11.746 1.00 95.45  ? 594  ARG A CZ    1 ? 
ATOM   4584 N NH1   . ARG A 1 592 ? -8.947  8.250   10.518 1.00 80.33  ? 594  ARG A NH1   1 ? 
ATOM   4585 N NH2   . ARG A 1 592 ? -10.719 7.796   11.909 1.00 93.13  ? 594  ARG A NH2   1 ? 
ATOM   4586 N N     . ILE A 1 593 ? -2.299  5.717   14.179 1.00 53.40  ? 595  ILE A N     1 ? 
ATOM   4587 C CA    . ILE A 1 593 ? -0.874  6.100   14.417 1.00 53.22  ? 595  ILE A CA    1 ? 
ATOM   4588 C C     . ILE A 1 593 ? 0.087   5.142   13.723 1.00 51.15  ? 595  ILE A C     1 ? 
ATOM   4589 O O     . ILE A 1 593 ? 1.276   5.457   13.698 1.00 53.30  ? 595  ILE A O     1 ? 
ATOM   4590 C CB    . ILE A 1 593 ? -0.540  6.159   15.918 1.00 54.66  ? 595  ILE A CB    1 ? 
ATOM   4591 C CG1   . ILE A 1 593 ? -0.748  4.805   16.593 1.00 52.49  ? 595  ILE A CG1   1 ? 
ATOM   4592 C CG2   . ILE A 1 593 ? -1.320  7.259   16.610 1.00 54.42  ? 595  ILE A CG2   1 ? 
ATOM   4593 C CD1   . ILE A 1 593 ? 0.013   4.677   17.865 1.00 52.16  ? 595  ILE A CD1   1 ? 
ATOM   4594 N N     . ARG A 1 594 ? -0.395  4.002   13.237 1.00 50.53  ? 596  ARG A N     1 ? 
ATOM   4595 C CA    . ARG A 1 594 ? 0.464   3.078   12.445 1.00 53.84  ? 596  ARG A CA    1 ? 
ATOM   4596 C C     . ARG A 1 594 ? 0.138   3.153   10.949 1.00 49.55  ? 596  ARG A C     1 ? 
ATOM   4597 O O     . ARG A 1 594 ? 0.966   2.725   10.165 1.00 55.66  ? 596  ARG A O     1 ? 
ATOM   4598 C CB    . ARG A 1 594 ? 0.357   1.633   12.929 1.00 50.02  ? 596  ARG A CB    1 ? 
ATOM   4599 C CG    . ARG A 1 594 ? -1.006  0.997   12.752 1.00 53.54  ? 596  ARG A CG    1 ? 
ATOM   4600 C CD    . ARG A 1 594 ? -1.265  -0.087  13.809 1.00 49.88  ? 596  ARG A CD    1 ? 
ATOM   4601 N NE    . ARG A 1 594 ? -1.230  0.438   15.162 1.00 49.96  ? 596  ARG A NE    1 ? 
ATOM   4602 C CZ    . ARG A 1 594 ? -0.274  0.201   16.055 1.00 48.43  ? 596  ARG A CZ    1 ? 
ATOM   4603 N NH1   . ARG A 1 594 ? 0.709   -0.650  15.791 1.00 52.32  ? 596  ARG A NH1   1 ? 
ATOM   4604 N NH2   . ARG A 1 594 ? -0.326  0.797   17.230 1.00 50.23  ? 596  ARG A NH2   1 ? 
ATOM   4605 N N     . GLY A 1 595 ? -1.036  3.645   10.588 1.00 52.96  ? 597  GLY A N     1 ? 
ATOM   4606 C CA    . GLY A 1 595 ? -1.398  3.954   9.193  1.00 54.09  ? 597  GLY A CA    1 ? 
ATOM   4607 C C     . GLY A 1 595 ? -1.948  2.772   8.437  1.00 56.38  ? 597  GLY A C     1 ? 
ATOM   4608 O O     . GLY A 1 595 ? -2.128  2.904   7.209  1.00 64.75  ? 597  GLY A O     1 ? 
ATOM   4609 N N     . PHE A 1 596 ? -2.190  1.657   9.113  1.00 51.69  ? 598  PHE A N     1 ? 
ATOM   4610 C CA    . PHE A 1 596 ? -2.709  0.439   8.460  1.00 54.30  ? 598  PHE A CA    1 ? 
ATOM   4611 C C     . PHE A 1 596 ? -3.612  -0.281  9.453  1.00 53.47  ? 598  PHE A C     1 ? 
ATOM   4612 O O     . PHE A 1 596 ? -3.596  -0.008  10.651 1.00 60.98  ? 598  PHE A O     1 ? 
ATOM   4613 C CB    . PHE A 1 596 ? -1.563  -0.455  7.940  1.00 51.30  ? 598  PHE A CB    1 ? 
ATOM   4614 C CG    . PHE A 1 596 ? -0.662  -1.008  9.015  1.00 50.68  ? 598  PHE A CG    1 ? 
ATOM   4615 C CD1   . PHE A 1 596 ? -1.087  -2.047  9.838  1.00 53.75  ? 598  PHE A CD1   1 ? 
ATOM   4616 C CD2   . PHE A 1 596 ? 0.570   -0.451  9.248  1.00 48.85  ? 598  PHE A CD2   1 ? 
ATOM   4617 C CE1   . PHE A 1 596 ? -0.276  -2.532  10.846 1.00 52.93  ? 598  PHE A CE1   1 ? 
ATOM   4618 C CE2   . PHE A 1 596 ? 1.395   -0.960  10.245 1.00 56.87  ? 598  PHE A CE2   1 ? 
ATOM   4619 C CZ    . PHE A 1 596 ? 0.971   -1.996  11.047 1.00 48.49  ? 598  PHE A CZ    1 ? 
ATOM   4620 N N     . VAL A 1 597 ? -4.368  -1.220  8.916  1.00 58.47  ? 599  VAL A N     1 ? 
ATOM   4621 C CA    . VAL A 1 597 ? -5.225  -2.133  9.707  1.00 54.51  ? 599  VAL A CA    1 ? 
ATOM   4622 C C     . VAL A 1 597 ? -5.050  -3.535  9.163  1.00 59.35  ? 599  VAL A C     1 ? 
ATOM   4623 O O     . VAL A 1 597 ? -4.925  -3.698  7.926  1.00 61.53  ? 599  VAL A O     1 ? 
ATOM   4624 C CB    . VAL A 1 597 ? -6.703  -1.700  9.688  1.00 58.97  ? 599  VAL A CB    1 ? 
ATOM   4625 C CG1   . VAL A 1 597 ? -6.945  -0.580  10.677 1.00 61.09  ? 599  VAL A CG1   1 ? 
ATOM   4626 C CG2   . VAL A 1 597 ? -7.151  -1.269  8.305  1.00 66.32  ? 599  VAL A CG2   1 ? 
ATOM   4627 N N     . LEU A 1 598 ? -5.057  -4.499  10.087 1.00 56.16  ? 600  LEU A N     1 ? 
ATOM   4628 C CA    . LEU A 1 598 ? -5.068  -5.925  9.713  1.00 57.54  ? 600  LEU A CA    1 ? 
ATOM   4629 C C     . LEU A 1 598 ? -6.512  -6.366  9.525  1.00 58.14  ? 600  LEU A C     1 ? 
ATOM   4630 O O     . LEU A 1 598 ? -7.333  -6.098  10.404 1.00 56.51  ? 600  LEU A O     1 ? 
ATOM   4631 C CB    . LEU A 1 598 ? -4.364  -6.755  10.781 1.00 55.28  ? 600  LEU A CB    1 ? 
ATOM   4632 C CG    . LEU A 1 598 ? -2.837  -6.747  10.753 1.00 55.57  ? 600  LEU A CG    1 ? 
ATOM   4633 C CD1   . LEU A 1 598 ? -2.288  -7.506  11.958 1.00 52.80  ? 600  LEU A CD1   1 ? 
ATOM   4634 C CD2   . LEU A 1 598 ? -2.306  -7.368  9.480  1.00 56.77  ? 600  LEU A CD2   1 ? 
ATOM   4635 N N     . LYS A 1 599 ? -6.786  -6.998  8.377  1.00 64.49  ? 601  LYS A N     1 ? 
ATOM   4636 C CA    . LYS A 1 599 ? -8.060  -7.684  8.107  1.00 58.94  ? 601  LYS A CA    1 ? 
ATOM   4637 C C     . LYS A 1 599 ? -7.874  -9.139  8.486  1.00 58.31  ? 601  LYS A C     1 ? 
ATOM   4638 O O     . LYS A 1 599 ? -7.175  -9.837  7.768  1.00 58.88  ? 601  LYS A O     1 ? 
ATOM   4639 C CB    . LYS A 1 599 ? -8.500  -7.486  6.661  1.00 67.87  ? 601  LYS A CB    1 ? 
ATOM   4640 C CG    . LYS A 1 599 ? -8.984  -6.074  6.332  1.00 86.10  ? 601  LYS A CG    1 ? 
ATOM   4641 C CD    . LYS A 1 599 ? -9.492  -5.243  7.518  1.00 85.58  ? 601  LYS A CD    1 ? 
ATOM   4642 C CE    . LYS A 1 599 ? -10.994 -5.357  7.702  1.00 91.12  ? 601  LYS A CE    1 ? 
ATOM   4643 N NZ    . LYS A 1 599 ? -11.429 -4.817  9.022  1.00 86.92  ? 601  LYS A NZ    1 ? 
ATOM   4644 N N     . LYS A 1 600 ? -8.539  -9.551  9.561  1.00 61.05  ? 602  LYS A N     1 ? 
ATOM   4645 C CA    . LYS A 1 600 ? -8.515  -10.946 10.065 1.00 56.41  ? 602  LYS A CA    1 ? 
ATOM   4646 C C     . LYS A 1 600 ? -9.672  -11.713 9.447  1.00 57.81  ? 602  LYS A C     1 ? 
ATOM   4647 O O     . LYS A 1 600 ? -10.606 -12.079 10.161 1.00 62.88  ? 602  LYS A O     1 ? 
ATOM   4648 C CB    . LYS A 1 600 ? -8.582  -10.925 11.591 1.00 57.65  ? 602  LYS A CB    1 ? 
ATOM   4649 C CG    . LYS A 1 600 ? -7.694  -9.857  12.207 1.00 54.88  ? 602  LYS A CG    1 ? 
ATOM   4650 C CD    . LYS A 1 600 ? -7.536  -10.014 13.688 1.00 54.99  ? 602  LYS A CD    1 ? 
ATOM   4651 C CE    . LYS A 1 600 ? -6.393  -9.169  14.213 1.00 49.05  ? 602  LYS A CE    1 ? 
ATOM   4652 N NZ    . LYS A 1 600 ? -6.356  -9.143  15.701 1.00 50.71  ? 602  LYS A NZ    1 ? 
ATOM   4653 N N     . THR A 1 601 ? -9.559  -11.982 8.155  1.00 63.41  ? 603  THR A N     1 ? 
ATOM   4654 C CA    . THR A 1 601 ? -10.671 -12.557 7.362  1.00 59.66  ? 603  THR A CA    1 ? 
ATOM   4655 C C     . THR A 1 601 ? -10.988 -13.961 7.858  1.00 54.87  ? 603  THR A C     1 ? 
ATOM   4656 O O     . THR A 1 601 ? -12.169 -14.300 8.027  1.00 66.07  ? 603  THR A O     1 ? 
ATOM   4657 C CB    . THR A 1 601 ? -10.336 -12.532 5.870  1.00 65.87  ? 603  THR A CB    1 ? 
ATOM   4658 O OG1   . THR A 1 601 ? -9.671  -11.288 5.601  1.00 66.17  ? 603  THR A OG1   1 ? 
ATOM   4659 C CG2   . THR A 1 601 ? -11.587 -12.680 5.035  1.00 64.12  ? 603  THR A CG2   1 ? 
ATOM   4660 N N     . ALA A 1 602 ? -9.982  -14.781 8.076  1.00 55.01  ? 604  ALA A N     1 ? 
ATOM   4661 C CA    . ALA A 1 602 ? -10.212 -16.189 8.464  1.00 57.35  ? 604  ALA A CA    1 ? 
ATOM   4662 C C     . ALA A 1 602 ? -9.185  -16.581 9.507  1.00 56.68  ? 604  ALA A C     1 ? 
ATOM   4663 O O     . ALA A 1 602 ? -8.096  -15.967 9.573  1.00 54.91  ? 604  ALA A O     1 ? 
ATOM   4664 C CB    . ALA A 1 602 ? -10.152 -17.117 7.267  1.00 60.93  ? 604  ALA A CB    1 ? 
ATOM   4665 N N     . MET A 1 603 ? -9.535  -17.582 10.293 1.00 57.07  ? 605  MET A N     1 ? 
ATOM   4666 C CA    . MET A 1 603 ? -8.619  -18.073 11.330 1.00 61.77  ? 605  MET A CA    1 ? 
ATOM   4667 C C     . MET A 1 603 ? -9.064  -19.453 11.800 1.00 63.63  ? 605  MET A C     1 ? 
ATOM   4668 O O     . MET A 1 603 ? -10.220 -19.600 12.186 1.00 67.01  ? 605  MET A O     1 ? 
ATOM   4669 C CB    . MET A 1 603 ? -8.600  -17.094 12.506 1.00 60.35  ? 605  MET A CB    1 ? 
ATOM   4670 C CG    . MET A 1 603 ? -8.057  -17.719 13.777 1.00 65.02  ? 605  MET A CG    1 ? 
ATOM   4671 S SD    . MET A 1 603 ? -6.273  -17.954 13.703 1.00 66.58  ? 605  MET A SD    1 ? 
ATOM   4672 C CE    . MET A 1 603 ? -5.762  -16.248 13.820 1.00 63.73  ? 605  MET A CE    1 ? 
ATOM   4673 N N     . ALA A 1 604 ? -8.151  -20.416 11.785 1.00 59.12  ? 606  ALA A N     1 ? 
ATOM   4674 C CA    . ALA A 1 604 ? -8.414  -21.758 12.336 1.00 55.31  ? 606  ALA A CA    1 ? 
ATOM   4675 C C     . ALA A 1 604 ? -7.936  -21.779 13.778 1.00 55.46  ? 606  ALA A C     1 ? 
ATOM   4676 O O     . ALA A 1 604 ? -6.966  -21.048 14.115 1.00 57.56  ? 606  ALA A O     1 ? 
ATOM   4677 C CB    . ALA A 1 604 ? -7.717  -22.821 11.533 1.00 53.25  ? 606  ALA A CB    1 ? 
ATOM   4678 N N     . VAL A 1 605 ? -8.596  -22.606 14.574 1.00 58.65  ? 607  VAL A N     1 ? 
ATOM   4679 C CA    . VAL A 1 605 ? -8.251  -22.790 16.000 1.00 60.84  ? 607  VAL A CA    1 ? 
ATOM   4680 C C     . VAL A 1 605 ? -8.093  -24.283 16.249 1.00 63.06  ? 607  VAL A C     1 ? 
ATOM   4681 O O     . VAL A 1 605 ? -9.018  -25.046 15.911 1.00 65.49  ? 607  VAL A O     1 ? 
ATOM   4682 C CB    . VAL A 1 605 ? -9.301  -22.154 16.919 1.00 62.89  ? 607  VAL A CB    1 ? 
ATOM   4683 C CG1   . VAL A 1 605 ? -8.878  -22.262 18.378 1.00 59.72  ? 607  VAL A CG1   1 ? 
ATOM   4684 C CG2   . VAL A 1 605 ? -9.558  -20.704 16.546 1.00 63.56  ? 607  VAL A CG2   1 ? 
ATOM   4685 N N     . MET A 1 606 ? -6.950  -24.666 16.816 1.00 67.44  ? 608  MET A N     1 ? 
ATOM   4686 C CA    . MET A 1 606 ? -6.764  -25.986 17.464 1.00 73.32  ? 608  MET A CA    1 ? 
ATOM   4687 C C     . MET A 1 606 ? -6.634  -25.796 18.969 1.00 69.22  ? 608  MET A C     1 ? 
ATOM   4688 O O     . MET A 1 606 ? -5.696  -25.117 19.380 1.00 73.65  ? 608  MET A O     1 ? 
ATOM   4689 C CB    . MET A 1 606 ? -5.513  -26.693 16.964 1.00 66.43  ? 608  MET A CB    1 ? 
ATOM   4690 C CG    . MET A 1 606 ? -5.313  -26.622 15.496 1.00 68.76  ? 608  MET A CG    1 ? 
ATOM   4691 S SD    . MET A 1 606 ? -3.759  -27.472 15.104 1.00 77.19  ? 608  MET A SD    1 ? 
ATOM   4692 C CE    . MET A 1 606 ? -3.839  -27.471 13.318 1.00 72.10  ? 608  MET A CE    1 ? 
ATOM   4693 N N     . ASP A 1 607 ? -7.529  -26.413 19.732 1.00 82.57  ? 609  ASP A N     1 ? 
ATOM   4694 C CA    . ASP A 1 607 ? -7.488  -26.394 21.216 1.00 88.11  ? 609  ASP A CA    1 ? 
ATOM   4695 C C     . ASP A 1 607 ? -7.015  -27.764 21.708 1.00 95.67  ? 609  ASP A C     1 ? 
ATOM   4696 O O     . ASP A 1 607 ? -6.637  -28.624 20.861 1.00 87.24  ? 609  ASP A O     1 ? 
ATOM   4697 C CB    . ASP A 1 607 ? -8.846  -25.979 21.785 1.00 89.75  ? 609  ASP A CB    1 ? 
ATOM   4698 C CG    . ASP A 1 607 ? -9.452  -24.809 21.040 1.00 98.44  ? 609  ASP A CG    1 ? 
ATOM   4699 O OD1   . ASP A 1 607 ? -10.052 -25.054 19.958 1.00 102.95 ? 609  ASP A OD1   1 ? 
ATOM   4700 O OD2   . ASP A 1 607 ? -9.297  -23.666 21.536 1.00 101.50 ? 609  ASP A OD2   1 ? 
ATOM   4701 N N     . CYS A 1 608 ? -6.985  -27.921 23.032 1.00 109.15 ? 610  CYS A N     1 ? 
ATOM   4702 C CA    . CYS A 1 608 ? -6.665  -29.205 23.711 1.00 110.80 ? 610  CYS A CA    1 ? 
ATOM   4703 C C     . CYS A 1 608 ? -5.340  -29.763 23.154 1.00 111.72 ? 610  CYS A C     1 ? 
ATOM   4704 O O     . CYS A 1 608 ? -4.559  -30.514 23.787 1.00 114.76 ? 610  CYS A O     1 ? 
ATOM   4705 C CB    . CYS A 1 608 ? -7.803  -30.210 23.533 1.00 112.81 ? 610  CYS A CB    1 ? 
ATOM   4706 S SG    . CYS A 1 608 ? -7.708  -31.618 24.674 1.00 121.08 ? 610  CYS A SG    1 ? 
HETATM 4707 N N1    . UPG B 2 .   ? 9.541   9.174   31.803 1.00 67.38  ? 700  UPG A N1    1 ? 
HETATM 4708 C C2    . UPG B 2 .   ? 8.965   9.086   33.060 1.00 71.67  ? 700  UPG A C2    1 ? 
HETATM 4709 N N3    . UPG B 2 .   ? 8.799   10.285  33.708 1.00 73.06  ? 700  UPG A N3    1 ? 
HETATM 4710 C C4    . UPG B 2 .   ? 9.164   11.537  33.244 1.00 69.64  ? 700  UPG A C4    1 ? 
HETATM 4711 C C5    . UPG B 2 .   ? 9.739   11.543  31.931 1.00 71.37  ? 700  UPG A C5    1 ? 
HETATM 4712 C C6    . UPG B 2 .   ? 9.910   10.386  31.273 1.00 66.99  ? 700  UPG A C6    1 ? 
HETATM 4713 O O2    . UPG B 2 .   ? 8.629   8.023   33.559 1.00 67.31  ? 700  UPG A O2    1 ? 
HETATM 4714 O O4    . UPG B 2 .   ? 8.947   12.533  33.931 1.00 65.28  ? 700  UPG A O4    1 ? 
HETATM 4715 C C1C   . UPG B 2 .   ? 9.769   7.919   31.075 1.00 60.00  ? 700  UPG A C1C   1 ? 
HETATM 4716 C C2C   . UPG B 2 .   ? 8.902   7.767   29.830 1.00 57.00  ? 700  UPG A C2C   1 ? 
HETATM 4717 O O2C   . UPG B 2 .   ? 7.618   7.307   30.179 1.00 50.80  ? 700  UPG A O2C   1 ? 
HETATM 4718 C C3C   . UPG B 2 .   ? 9.721   6.739   29.045 1.00 57.03  ? 700  UPG A C3C   1 ? 
HETATM 4719 C C4C   . UPG B 2 .   ? 11.170  7.110   29.411 1.00 61.41  ? 700  UPG A C4C   1 ? 
HETATM 4720 O O4C   . UPG B 2 .   ? 11.093  7.921   30.606 1.00 62.17  ? 700  UPG A O4C   1 ? 
HETATM 4721 O O3C   . UPG B 2 .   ? 9.451   5.399   29.439 1.00 60.73  ? 700  UPG A O3C   1 ? 
HETATM 4722 C C5C   . UPG B 2 .   ? 11.964  7.862   28.376 1.00 60.83  ? 700  UPG A C5C   1 ? 
HETATM 4723 O O5C   . UPG B 2 .   ? 11.305  9.097   28.029 1.00 62.74  ? 700  UPG A O5C   1 ? 
HETATM 4724 P PA    . UPG B 2 .   ? 11.353  9.516   26.476 1.00 66.00  ? 700  UPG A PA    1 ? 
HETATM 4725 O O1A   . UPG B 2 .   ? 10.725  10.847  26.329 1.00 70.63  ? 700  UPG A O1A   1 ? 
HETATM 4726 O O2A   . UPG B 2 .   ? 10.853  8.412   25.612 1.00 72.94  ? 700  UPG A O2A   1 ? 
HETATM 4727 O O3A   . UPG B 2 .   ? 12.938  9.575   26.267 1.00 75.06  ? 700  UPG A O3A   1 ? 
HETATM 4728 P PB    . UPG B 2 .   ? 14.038  10.662  26.636 1.00 63.82  ? 700  UPG A PB    1 ? 
HETATM 4729 O O1B   . UPG B 2 .   ? 14.007  10.946  28.093 1.00 73.27  ? 700  UPG A O1B   1 ? 
HETATM 4730 O O2B   . UPG B 2 .   ? 13.800  11.775  25.670 1.00 69.67  ? 700  UPG A O2B   1 ? 
HETATM 4731 O O3B   . UPG B 2 .   ? 15.389  9.849   26.324 1.00 72.50  ? 700  UPG A O3B   1 ? 
HETATM 4732 C "C1'" . UPG B 2 .   ? 15.778  8.738   27.061 1.00 67.60  ? 700  UPG A "C1'" 1 ? 
HETATM 4733 C "C2'" . UPG B 2 .   ? 17.203  8.937   27.575 1.00 67.89  ? 700  UPG A "C2'" 1 ? 
HETATM 4734 C "C3'" . UPG B 2 .   ? 18.201  8.947   26.443 1.00 69.64  ? 700  UPG A "C3'" 1 ? 
HETATM 4735 C "C4'" . UPG B 2 .   ? 18.025  7.698   25.601 1.00 73.56  ? 700  UPG A "C4'" 1 ? 
HETATM 4736 C "C5'" . UPG B 2 .   ? 16.580  7.578   25.118 1.00 70.70  ? 700  UPG A "C5'" 1 ? 
HETATM 4737 C "C6'" . UPG B 2 .   ? 16.323  6.261   24.396 1.00 68.22  ? 700  UPG A "C6'" 1 ? 
HETATM 4738 O "O2'" . UPG B 2 .   ? 17.278  10.153  28.294 1.00 64.63  ? 700  UPG A "O2'" 1 ? 
HETATM 4739 O "O3'" . UPG B 2 .   ? 19.534  9.004   26.954 1.00 71.14  ? 700  UPG A "O3'" 1 ? 
HETATM 4740 O "O4'" . UPG B 2 .   ? 18.882  7.737   24.469 1.00 66.33  ? 700  UPG A "O4'" 1 ? 
HETATM 4741 O "O5'" . UPG B 2 .   ? 15.691  7.602   26.232 1.00 59.82  ? 700  UPG A "O5'" 1 ? 
HETATM 4742 O "O6'" . UPG B 2 .   ? 15.005  6.178   23.891 1.00 60.24  ? 700  UPG A "O6'" 1 ? 
HETATM 4743 P P1    . POP C 3 .   ? 6.814   20.854  26.909 0.50 78.16  ? 701  POP A P1    1 ? 
HETATM 4744 O O1    . POP C 3 .   ? 6.765   19.578  26.119 0.50 65.90  ? 701  POP A O1    1 ? 
HETATM 4745 O O2    . POP C 3 .   ? 7.506   21.970  26.176 0.50 85.13  ? 701  POP A O2    1 ? 
HETATM 4746 O O3    . POP C 3 .   ? 7.349   20.654  28.297 0.50 68.39  ? 701  POP A O3    1 ? 
HETATM 4747 O O     . POP C 3 .   ? 5.293   21.316  27.096 0.50 78.39  ? 701  POP A O     1 ? 
HETATM 4748 P P2    . POP C 3 .   ? 4.035   21.327  26.098 0.50 99.27  ? 701  POP A P2    1 ? 
HETATM 4749 O O4    . POP C 3 .   ? 3.409   19.960  26.194 0.50 102.79 ? 701  POP A O4    1 ? 
HETATM 4750 O O5    . POP C 3 .   ? 3.129   22.423  26.591 0.50 83.72  ? 701  POP A O5    1 ? 
HETATM 4751 O O6    . POP C 3 .   ? 4.601   21.609  24.736 0.50 90.53  ? 701  POP A O6    1 ? 
HETATM 4752 P P1    . POP D 3 .   ? 2.864   25.573  20.281 0.50 110.87 ? 702  POP A P1    1 ? 
HETATM 4753 O O1    . POP D 3 .   ? 3.714   24.689  21.151 0.50 95.61  ? 702  POP A O1    1 ? 
HETATM 4754 O O2    . POP D 3 .   ? 3.024   27.031  20.600 0.50 103.33 ? 702  POP A O2    1 ? 
HETATM 4755 O O3    . POP D 3 .   ? 1.425   25.144  20.242 0.50 103.47 ? 702  POP A O3    1 ? 
HETATM 4756 O O     . POP D 3 .   ? 3.411   25.385  18.781 0.50 110.59 ? 702  POP A O     1 ? 
HETATM 4757 P P2    . POP D 3 .   ? 3.425   24.149  17.742 0.50 104.32 ? 702  POP A P2    1 ? 
HETATM 4758 O O4    . POP D 3 .   ? 1.993   23.695  17.614 0.50 104.13 ? 702  POP A O4    1 ? 
HETATM 4759 O O5    . POP D 3 .   ? 3.975   24.706  16.455 0.50 88.99  ? 702  POP A O5    1 ? 
HETATM 4760 O O6    . POP D 3 .   ? 4.321   23.099  18.350 0.50 96.31  ? 702  POP A O6    1 ? 
HETATM 4761 O O     . HOH E 4 .   ? -6.793  8.250   28.410 1.00 75.21  ? 801  HOH A O     1 ? 
HETATM 4762 O O     . HOH E 4 .   ? -5.517  -10.881 21.138 1.00 71.90  ? 802  HOH A O     1 ? 
HETATM 4763 O O     . HOH E 4 .   ? 19.332  -9.509  14.403 1.00 72.55  ? 803  HOH A O     1 ? 
HETATM 4764 O O     . HOH E 4 .   ? 10.272  15.963  43.783 1.00 67.04  ? 804  HOH A O     1 ? 
HETATM 4765 O O     . HOH E 4 .   ? 15.428  -31.312 15.152 1.00 66.96  ? 805  HOH A O     1 ? 
HETATM 4766 O O     . HOH E 4 .   ? 12.281  19.776  28.479 1.00 67.56  ? 806  HOH A O     1 ? 
HETATM 4767 O O     . HOH E 4 .   ? 25.208  -14.688 17.798 1.00 76.69  ? 807  HOH A O     1 ? 
HETATM 4768 O O     . HOH E 4 .   ? -9.623  -13.551 34.934 1.00 67.50  ? 808  HOH A O     1 ? 
HETATM 4769 O O     . HOH E 4 .   ? 25.775  21.541  40.642 1.00 78.95  ? 809  HOH A O     1 ? 
HETATM 4770 O O     . HOH E 4 .   ? 13.087  -14.549 21.163 1.00 60.01  ? 810  HOH A O     1 ? 
HETATM 4771 O O     . HOH E 4 .   ? 13.633  -6.714  59.243 1.00 93.98  ? 811  HOH A O     1 ? 
HETATM 4772 O O     . HOH E 4 .   ? -2.584  -9.555  27.552 1.00 46.84  ? 812  HOH A O     1 ? 
HETATM 4773 O O     . HOH E 4 .   ? 14.168  -15.260 5.394  1.00 70.74  ? 813  HOH A O     1 ? 
HETATM 4774 O O     . HOH E 4 .   ? 24.588  27.203  26.186 1.00 77.58  ? 814  HOH A O     1 ? 
HETATM 4775 O O     . HOH E 4 .   ? 15.162  13.334  40.155 1.00 64.97  ? 815  HOH A O     1 ? 
HETATM 4776 O O     . HOH E 4 .   ? -10.665 -19.268 4.452  1.00 63.59  ? 816  HOH A O     1 ? 
HETATM 4777 O O     . HOH E 4 .   ? 34.316  14.053  36.161 1.00 82.77  ? 817  HOH A O     1 ? 
HETATM 4778 O O     . HOH E 4 .   ? -7.001  -11.205 17.265 1.00 64.02  ? 818  HOH A O     1 ? 
HETATM 4779 O O     . HOH E 4 .   ? 8.777   -3.653  18.686 1.00 48.86  ? 819  HOH A O     1 ? 
HETATM 4780 O O     . HOH E 4 .   ? 8.529   -20.429 4.606  1.00 59.25  ? 820  HOH A O     1 ? 
HETATM 4781 O O     . HOH E 4 .   ? 19.705  -19.959 24.499 1.00 60.23  ? 821  HOH A O     1 ? 
HETATM 4782 O O     . HOH E 4 .   ? 30.402  28.799  28.750 1.00 75.74  ? 822  HOH A O     1 ? 
HETATM 4783 O O     . HOH E 4 .   ? 27.140  31.164  35.040 1.00 60.64  ? 823  HOH A O     1 ? 
HETATM 4784 O O     . HOH E 4 .   ? -8.511  0.281   38.971 1.00 75.32  ? 824  HOH A O     1 ? 
HETATM 4785 O O     . HOH E 4 .   ? 20.454  -24.393 16.158 1.00 68.24  ? 825  HOH A O     1 ? 
HETATM 4786 O O     . HOH E 4 .   ? 10.626  3.677   24.442 1.00 64.80  ? 826  HOH A O     1 ? 
HETATM 4787 O O     . HOH E 4 .   ? 23.562  19.610  38.214 1.00 69.12  ? 827  HOH A O     1 ? 
HETATM 4788 O O     . HOH E 4 .   ? 1.514   0.639   19.285 1.00 50.51  ? 828  HOH A O     1 ? 
HETATM 4789 O O     . HOH E 4 .   ? -2.339  -14.754 7.412  1.00 57.65  ? 829  HOH A O     1 ? 
HETATM 4790 O O     . HOH E 4 .   ? -4.370  -30.765 10.023 1.00 65.54  ? 830  HOH A O     1 ? 
HETATM 4791 O O     . HOH E 4 .   ? 15.308  25.315  51.933 1.00 66.31  ? 831  HOH A O     1 ? 
HETATM 4792 O O     . HOH E 4 .   ? -3.833  -20.948 26.633 1.00 73.42  ? 832  HOH A O     1 ? 
HETATM 4793 O O     . HOH E 4 .   ? -2.569  36.960  43.738 1.00 75.59  ? 833  HOH A O     1 ? 
HETATM 4794 O O     . HOH E 4 .   ? -8.902  -17.118 23.460 1.00 63.81  ? 834  HOH A O     1 ? 
HETATM 4795 O O     . HOH E 4 .   ? 0.468   -31.481 2.066  1.00 89.81  ? 835  HOH A O     1 ? 
HETATM 4796 O O     . HOH E 4 .   ? 12.641  3.150   12.808 1.00 67.87  ? 836  HOH A O     1 ? 
HETATM 4797 O O     . HOH E 4 .   ? 32.776  -6.691  15.119 1.00 78.57  ? 837  HOH A O     1 ? 
HETATM 4798 O O     . HOH E 4 .   ? 9.653   -10.797 21.790 1.00 68.98  ? 838  HOH A O     1 ? 
HETATM 4799 O O     . HOH E 4 .   ? 13.209  3.631   24.677 1.00 54.42  ? 839  HOH A O     1 ? 
HETATM 4800 O O     . HOH E 4 .   ? 6.481   -12.541 13.094 1.00 58.21  ? 840  HOH A O     1 ? 
HETATM 4801 O O     . HOH E 4 .   ? -0.550  -11.525 36.153 1.00 74.60  ? 841  HOH A O     1 ? 
HETATM 4802 O O     . HOH E 4 .   ? 11.976  -1.394  27.484 1.00 54.23  ? 842  HOH A O     1 ? 
HETATM 4803 O O     . HOH E 4 .   ? 3.597   6.246   15.181 1.00 57.45  ? 843  HOH A O     1 ? 
HETATM 4804 O O     . HOH E 4 .   ? 5.722   -18.744 39.614 1.00 53.95  ? 844  HOH A O     1 ? 
HETATM 4805 O O     . HOH E 4 .   ? 33.716  -7.144  22.284 1.00 76.13  ? 845  HOH A O     1 ? 
HETATM 4806 O O     . HOH E 4 .   ? 2.048   -14.000 33.927 1.00 67.73  ? 846  HOH A O     1 ? 
HETATM 4807 O O     . HOH E 4 .   ? -9.251  3.171   4.780  0.50 66.87  ? 847  HOH A O     1 ? 
HETATM 4808 O O     . HOH E 4 .   ? 4.692   6.180   29.870 1.00 60.66  ? 848  HOH A O     1 ? 
HETATM 4809 O O     . HOH E 4 .   ? 12.984  15.964  11.251 1.00 75.24  ? 849  HOH A O     1 ? 
HETATM 4810 O O     . HOH E 4 .   ? 15.180  11.770  48.208 1.00 80.28  ? 850  HOH A O     1 ? 
HETATM 4811 O O     . HOH E 4 .   ? 20.867  -11.652 39.208 1.00 67.28  ? 851  HOH A O     1 ? 
HETATM 4812 O O     . HOH E 4 .   ? 0.983   0.278   -0.959 1.00 77.26  ? 852  HOH A O     1 ? 
HETATM 4813 O O     . HOH E 4 .   ? 14.983  1.687   25.529 1.00 56.31  ? 853  HOH A O     1 ? 
HETATM 4814 O O     . HOH E 4 .   ? -8.589  8.925   15.653 1.00 68.45  ? 854  HOH A O     1 ? 
HETATM 4815 O O     . HOH E 4 .   ? -4.755  -6.449  25.447 1.00 62.45  ? 855  HOH A O     1 ? 
HETATM 4816 O O     . HOH E 4 .   ? -7.868  -8.219  20.525 1.00 68.16  ? 856  HOH A O     1 ? 
HETATM 4817 O O     . HOH E 4 .   ? -1.408  -19.362 27.929 1.00 67.05  ? 857  HOH A O     1 ? 
HETATM 4818 O O     . HOH E 4 .   ? -1.643  -6.299  40.256 1.00 75.25  ? 859  HOH A O     1 ? 
HETATM 4819 O O     . HOH E 4 .   ? 28.513  25.014  35.627 1.00 76.14  ? 860  HOH A O     1 ? 
HETATM 4820 O O     . HOH E 4 .   ? -4.356  -3.648  12.865 1.00 53.13  ? 861  HOH A O     1 ? 
HETATM 4821 O O     . HOH E 4 .   ? 31.695  6.480   43.931 1.00 80.20  ? 862  HOH A O     1 ? 
HETATM 4822 O O     . HOH E 4 .   ? 17.415  36.556  51.760 1.00 82.95  ? 863  HOH A O     1 ? 
HETATM 4823 O O     . HOH E 4 .   ? 9.851   29.875  56.121 1.00 85.96  ? 864  HOH A O     1 ? 
HETATM 4824 O O     . HOH E 4 .   ? -0.864  -12.114 4.167  1.00 67.73  ? 865  HOH A O     1 ? 
HETATM 4825 O O     . HOH E 4 .   ? -4.078  8.369   34.240 1.00 64.07  ? 866  HOH A O     1 ? 
HETATM 4826 O O     . HOH E 4 .   ? 21.464  5.453   53.767 1.00 71.89  ? 867  HOH A O     1 ? 
HETATM 4827 O O     . HOH E 4 .   ? 23.568  -2.589  13.826 1.00 56.87  ? 868  HOH A O     1 ? 
HETATM 4828 O O     . HOH E 4 .   ? 6.068   -11.071 26.835 1.00 70.75  ? 869  HOH A O     1 ? 
HETATM 4829 O O     . HOH E 4 .   ? 18.015  7.375   13.143 1.00 82.79  ? 870  HOH A O     1 ? 
HETATM 4830 O O     . HOH E 4 .   ? 3.195   15.377  14.035 1.00 79.28  ? 871  HOH A O     1 ? 
HETATM 4831 O O     . HOH E 4 .   ? 21.141  8.687   55.804 1.00 74.89  ? 872  HOH A O     1 ? 
HETATM 4832 O O     . HOH E 4 .   ? 2.584   33.401  35.567 1.00 65.98  ? 873  HOH A O     1 ? 
HETATM 4833 O O     . HOH E 4 .   ? 18.011  12.936  2.223  1.00 82.26  ? 874  HOH A O     1 ? 
HETATM 4834 O O     . HOH E 4 .   ? 3.972   -15.312 32.824 1.00 58.41  ? 875  HOH A O     1 ? 
HETATM 4835 O O     . HOH E 4 .   ? 34.126  -7.783  18.583 1.00 75.90  ? 876  HOH A O     1 ? 
HETATM 4836 O O     . HOH E 4 .   ? 12.597  -10.457 -1.644 1.00 79.98  ? 877  HOH A O     1 ? 
HETATM 4837 O O     . HOH E 4 .   ? -7.834  -6.402  16.327 1.00 71.73  ? 878  HOH A O     1 ? 
HETATM 4838 O O     . HOH E 4 .   ? -6.134  -5.616  3.107  1.00 76.20  ? 879  HOH A O     1 ? 
HETATM 4839 O O     . HOH E 4 .   ? 10.240  2.170   2.490  1.00 63.45  ? 880  HOH A O     1 ? 
HETATM 4840 O O     . HOH E 4 .   ? 9.638   38.161  23.730 1.00 81.12  ? 881  HOH A O     1 ? 
HETATM 4841 O O     . HOH E 4 .   ? -6.844  2.990   30.406 1.00 69.01  ? 882  HOH A O     1 ? 
HETATM 4842 O O     . HOH E 4 .   ? 6.318   32.108  30.252 1.00 67.93  ? 883  HOH A O     1 ? 
HETATM 4843 O O     . HOH E 4 .   ? 31.777  -14.041 26.139 1.00 74.87  ? 884  HOH A O     1 ? 
HETATM 4844 O O     . HOH E 4 .   ? 18.082  -27.377 21.113 1.00 68.64  ? 885  HOH A O     1 ? 
HETATM 4845 O O     . HOH E 4 .   ? -11.383 -17.226 22.286 1.00 77.34  ? 886  HOH A O     1 ? 
HETATM 4846 O O     . HOH E 4 .   ? -8.966  38.580  49.335 1.00 80.57  ? 887  HOH A O     1 ? 
HETATM 4847 O O     . HOH E 4 .   ? 12.300  22.774  30.923 1.00 69.05  ? 888  HOH A O     1 ? 
HETATM 4848 O O     . HOH E 4 .   ? 21.192  23.289  33.328 1.00 67.92  ? 889  HOH A O     1 ? 
HETATM 4849 O O     . HOH E 4 .   ? -2.000  -12.143 54.593 1.00 79.46  ? 890  HOH A O     1 ? 
HETATM 4850 O O     . HOH E 4 .   ? -0.522  -37.123 16.498 1.00 79.09  ? 891  HOH A O     1 ? 
HETATM 4851 O O     . HOH E 4 .   ? -10.450 -7.549  11.255 1.00 68.55  ? 892  HOH A O     1 ? 
HETATM 4852 O O     . HOH E 4 .   ? 13.547  14.528  0.925  1.00 72.90  ? 893  HOH A O     1 ? 
HETATM 4853 O O     . HOH E 4 .   ? 18.464  20.352  47.766 1.00 76.68  ? 894  HOH A O     1 ? 
HETATM 4854 O O     . HOH E 4 .   ? -4.671  -25.367 31.748 1.00 76.88  ? 895  HOH A O     1 ? 
HETATM 4855 O O     . HOH E 4 .   ? 12.888  18.760  52.866 1.00 72.44  ? 896  HOH A O     1 ? 
HETATM 4856 O O     . HOH E 4 .   ? 14.078  -15.490 2.725  1.00 66.98  ? 897  HOH A O     1 ? 
HETATM 4857 O O     . HOH E 4 .   ? -0.592  22.473  36.235 1.00 66.52  ? 898  HOH A O     1 ? 
HETATM 4858 O O     . HOH E 4 .   ? 10.232  -9.798  47.196 1.00 57.76  ? 899  HOH A O     1 ? 
HETATM 4859 O O     . HOH E 4 .   ? 10.985  -2.006  11.004 1.00 75.55  ? 900  HOH A O     1 ? 
HETATM 4860 O O     . HOH E 4 .   ? -11.590 -23.650 13.646 1.00 59.85  ? 901  HOH A O     1 ? 
HETATM 4861 O O     . HOH E 4 .   ? 21.204  -3.670  13.041 1.00 62.96  ? 902  HOH A O     1 ? 
HETATM 4862 O O     . HOH E 4 .   ? 37.445  -10.095 30.053 1.00 76.77  ? 903  HOH A O     1 ? 
HETATM 4863 O O     . HOH E 4 .   ? 11.293  16.544  5.870  1.00 66.17  ? 904  HOH A O     1 ? 
HETATM 4864 O O     . HOH E 4 .   ? 6.734   -12.151 49.076 1.00 75.17  ? 905  HOH A O     1 ? 
HETATM 4865 O O     . HOH E 4 .   ? -14.458 -3.837  12.229 1.00 90.18  ? 906  HOH A O     1 ? 
HETATM 4866 O O     . HOH E 4 .   ? 16.911  -14.631 25.451 1.00 56.99  ? 907  HOH A O     1 ? 
HETATM 4867 O O     . HOH E 4 .   ? 0.218   -15.232 21.349 1.00 50.22  ? 908  HOH A O     1 ? 
HETATM 4868 O O     . HOH E 4 .   ? -11.790 -2.388  6.775  1.00 71.14  ? 909  HOH A O     1 ? 
HETATM 4869 O O     . HOH E 4 .   ? -12.216 -25.976 16.247 1.00 78.42  ? 910  HOH A O     1 ? 
HETATM 4870 O O     . HOH E 4 .   ? -8.777  -28.144 25.869 1.00 75.58  ? 911  HOH A O     1 ? 
HETATM 4871 O O     . HOH E 4 .   ? 13.603  -27.835 5.488  1.00 71.93  ? 912  HOH A O     1 ? 
HETATM 4872 O O     . HOH E 4 .   ? 30.580  -19.146 18.154 1.00 79.17  ? 913  HOH A O     1 ? 
HETATM 4873 O O     . HOH E 4 .   ? -0.733  -34.920 6.635  1.00 66.39  ? 914  HOH A O     1 ? 
HETATM 4874 O O     . HOH E 4 .   ? -9.831  -27.037 13.200 1.00 74.57  ? 915  HOH A O     1 ? 
HETATM 4875 O O     . HOH E 4 .   ? -11.122 34.414  56.202 1.00 77.85  ? 916  HOH A O     1 ? 
HETATM 4876 O O     . HOH E 4 .   ? 21.865  22.482  30.878 1.00 73.48  ? 917  HOH A O     1 ? 
HETATM 4877 O O     . HOH E 4 .   ? 9.728   40.109  44.873 1.00 68.54  ? 918  HOH A O     1 ? 
HETATM 4878 O O     . HOH E 4 .   ? 1.829   -34.229 7.465  1.00 81.97  ? 919  HOH A O     1 ? 
HETATM 4879 O O     . HOH E 4 .   ? 0.478   -8.777  48.147 1.00 69.57  ? 920  HOH A O     1 ? 
HETATM 4880 O O     . HOH E 4 .   ? -2.696  -1.498  1.009  1.00 67.51  ? 921  HOH A O     1 ? 
HETATM 4881 O O     . HOH E 4 .   ? 14.402  8.045   19.873 1.00 70.80  ? 922  HOH A O     1 ? 
HETATM 4882 O O     . HOH E 4 .   ? 5.677   -22.886 2.851  1.00 61.85  ? 923  HOH A O     1 ? 
HETATM 4883 O O     . HOH E 4 .   ? -3.602  -31.529 17.704 1.00 85.12  ? 924  HOH A O     1 ? 
HETATM 4884 O O     . HOH E 4 .   ? 16.878  -26.913 23.893 1.00 67.46  ? 925  HOH A O     1 ? 
HETATM 4885 O O     . HOH E 4 .   ? 32.431  22.653  12.428 1.00 80.13  ? 926  HOH A O     1 ? 
HETATM 4886 O O     . HOH E 4 .   ? -13.384 -17.409 6.835  1.00 78.13  ? 927  HOH A O     1 ? 
HETATM 4887 O O     . HOH E 4 .   ? 42.175  20.057  30.075 1.00 79.18  ? 928  HOH A O     1 ? 
HETATM 4888 O O     . HOH E 4 .   ? -7.763  43.895  57.687 1.00 75.89  ? 929  HOH A O     1 ? 
HETATM 4889 O O     . HOH E 4 .   ? -9.461  1.161   6.370  0.50 73.78  ? 930  HOH A O     1 ? 
HETATM 4890 O O     . HOH E 4 .   ? 18.869  -16.925 10.655 1.00 56.41  ? 931  HOH A O     1 ? 
HETATM 4891 O O     . HOH E 4 .   ? -2.092  -15.386 26.240 1.00 65.58  ? 932  HOH A O     1 ? 
HETATM 4892 O O     . HOH E 4 .   ? 22.520  -17.152 38.483 1.00 78.40  ? 933  HOH A O     1 ? 
HETATM 4893 O O     . HOH E 4 .   ? 11.358  6.016   54.179 1.00 82.96  ? 934  HOH A O     1 ? 
HETATM 4894 O O     . HOH E 4 .   ? 18.235  21.012  21.717 1.00 71.75  ? 935  HOH A O     1 ? 
HETATM 4895 O O     . HOH E 4 .   ? -2.106  -32.036 2.101  1.00 65.97  ? 936  HOH A O     1 ? 
HETATM 4896 O O     . HOH E 4 .   ? 10.108  -5.896  8.582  1.00 57.21  ? 937  HOH A O     1 ? 
HETATM 4897 O O     . HOH E 4 .   ? 7.408   -12.597 22.329 1.00 59.93  ? 938  HOH A O     1 ? 
HETATM 4898 O O     . HOH E 4 .   ? 26.590  -4.438  16.629 1.00 74.99  ? 939  HOH A O     1 ? 
HETATM 4899 O O     . HOH E 4 .   ? 9.247   -14.835 22.470 1.00 66.80  ? 940  HOH A O     1 ? 
HETATM 4900 O O     . HOH E 4 .   ? 25.778  11.581  47.228 1.00 77.09  ? 941  HOH A O     1 ? 
HETATM 4901 O O     . HOH E 4 .   ? -11.288 -21.469 9.174  1.00 70.21  ? 942  HOH A O     1 ? 
HETATM 4902 O O     . HOH E 4 .   ? 11.826  -0.117  15.358 1.00 63.52  ? 943  HOH A O     1 ? 
HETATM 4903 O O     . HOH E 4 .   ? 17.969  -3.919  10.306 1.00 70.79  ? 944  HOH A O     1 ? 
HETATM 4904 O O     . HOH E 4 .   ? 12.973  -19.127 32.235 1.00 67.53  ? 945  HOH A O     1 ? 
HETATM 4905 O O     . HOH E 4 .   ? 9.397   12.066  45.564 1.00 71.00  ? 946  HOH A O     1 ? 
HETATM 4906 O O     . HOH E 4 .   ? 12.780  14.813  49.624 1.00 67.98  ? 947  HOH A O     1 ? 
HETATM 4907 O O     . HOH E 4 .   ? 15.133  -15.350 44.710 1.00 68.84  ? 948  HOH A O     1 ? 
HETATM 4908 O O     . HOH E 4 .   ? 44.475  28.873  18.544 1.00 73.84  ? 949  HOH A O     1 ? 
HETATM 4909 O O     . HOH E 4 .   ? 42.719  28.289  16.531 1.00 88.07  ? 950  HOH A O     1 ? 
HETATM 4910 O O     . HOH E 4 .   ? 3.846   -11.686 22.820 1.00 59.21  ? 951  HOH A O     1 ? 
HETATM 4911 O O     . HOH E 4 .   ? 38.095  -5.714  30.557 1.00 72.37  ? 952  HOH A O     1 ? 
HETATM 4912 O O     . HOH E 4 .   ? 11.825  -4.523  10.679 1.00 56.82  ? 953  HOH A O     1 ? 
HETATM 4913 O O     . HOH E 4 .   ? 26.602  -15.538 42.761 1.00 78.51  ? 954  HOH A O     1 ? 
HETATM 4914 O O     . HOH E 4 .   ? -15.046 31.588  48.936 1.00 86.69  ? 955  HOH A O     1 ? 
HETATM 4915 O O     . HOH E 4 .   ? 37.205  -8.122  32.070 1.00 84.92  ? 956  HOH A O     1 ? 
HETATM 4916 O O     . HOH E 4 .   ? 2.269   25.173  29.506 1.00 79.59  ? 957  HOH A O     1 ? 
HETATM 4917 O O     . HOH E 4 .   ? 14.296  6.500   54.496 1.00 81.50  ? 958  HOH A O     1 ? 
HETATM 4918 O O     . HOH E 4 .   ? 0.636   16.666  56.994 1.00 86.74  ? 959  HOH A O     1 ? 
HETATM 4919 O O     . HOH E 4 .   ? 10.513  42.994  47.930 1.00 74.81  ? 960  HOH A O     1 ? 
HETATM 4920 O O     . HOH E 4 .   ? 0.261   -16.080 31.830 1.00 63.58  ? 961  HOH A O     1 ? 
HETATM 4921 O O     . HOH E 4 .   ? -7.727  13.377  23.439 1.00 81.91  ? 962  HOH A O     1 ? 
HETATM 4922 O O     . HOH E 4 .   ? 28.380  -16.465 12.759 1.00 64.61  ? 963  HOH A O     1 ? 
HETATM 4923 O O     . HOH E 4 .   ? 20.618  -9.623  8.729  1.00 74.52  ? 964  HOH A O     1 ? 
HETATM 4924 O O     . HOH E 4 .   ? 0.433   14.077  15.420 1.00 81.17  ? 965  HOH A O     1 ? 
HETATM 4925 O O     . HOH E 4 .   ? 5.419   33.371  66.456 1.00 83.99  ? 966  HOH A O     1 ? 
HETATM 4926 O O     . HOH E 4 .   ? -8.243  -19.075 29.344 0.50 84.26  ? 967  HOH A O     1 ? 
HETATM 4927 O O     . HOH E 4 .   ? -9.115  28.659  32.920 1.00 81.25  ? 968  HOH A O     1 ? 
HETATM 4928 O O     . HOH E 4 .   ? 3.725   0.437   61.782 1.00 88.06  ? 969  HOH A O     1 ? 
HETATM 4929 O O     . HOH E 4 .   ? 0.152   18.077  28.078 1.00 70.78  ? 970  HOH A O     1 ? 
HETATM 4930 O O     . HOH E 4 .   ? -10.160 -30.931 21.179 1.00 69.35  ? 971  HOH A O     1 ? 
HETATM 4931 O O     . HOH E 4 .   ? 14.492  -3.955  9.865  1.00 69.71  ? 972  HOH A O     1 ? 
HETATM 4932 O O     . HOH E 4 .   ? -3.908  -33.982 19.743 1.00 69.79  ? 973  HOH A O     1 ? 
HETATM 4933 O O     . HOH E 4 .   ? 23.298  -9.619  50.873 1.00 77.18  ? 974  HOH A O     1 ? 
HETATM 4934 O O     . HOH E 4 .   ? 29.364  2.117   18.100 1.00 72.25  ? 975  HOH A O     1 ? 
HETATM 4935 O O     . HOH E 4 .   ? 12.619  -1.043  -1.088 1.00 77.50  ? 976  HOH A O     1 ? 
HETATM 4936 O O     . HOH E 4 .   ? 29.084  26.409  33.697 1.00 68.26  ? 977  HOH A O     1 ? 
HETATM 4937 O O     . HOH E 4 .   ? 10.181  -1.427  8.491  1.00 67.71  ? 978  HOH A O     1 ? 
HETATM 4938 O O     . HOH E 4 .   ? 18.994  -17.018 8.031  1.00 61.11  ? 979  HOH A O     1 ? 
HETATM 4939 O O     . HOH E 4 .   ? -3.684  -36.238 13.582 1.00 86.34  ? 980  HOH A O     1 ? 
HETATM 4940 O O     . HOH E 4 .   ? -5.286  11.361  12.318 1.00 71.55  ? 981  HOH A O     1 ? 
HETATM 4941 O O     . HOH E 4 .   ? 31.628  -0.589  19.561 1.00 75.54  ? 982  HOH A O     1 ? 
HETATM 4942 O O     . HOH E 4 .   ? 21.849  -19.686 39.887 1.00 77.75  ? 983  HOH A O     1 ? 
HETATM 4943 O O     . HOH E 4 .   ? 33.432  -0.978  14.190 1.00 84.51  ? 984  HOH A O     1 ? 
HETATM 4944 O O     . HOH E 4 .   ? -5.966  29.683  28.851 1.00 79.84  ? 985  HOH A O     1 ? 
HETATM 4945 O O     . HOH E 4 .   ? 5.649   14.021  58.336 1.00 76.14  ? 986  HOH A O     1 ? 
HETATM 4946 O O     . HOH E 4 .   ? 16.237  -23.171 5.179  1.00 79.41  ? 987  HOH A O     1 ? 
HETATM 4947 O O     . HOH E 4 .   ? -2.440  -17.631 35.017 1.00 75.51  ? 988  HOH A O     1 ? 
HETATM 4948 O O     . HOH E 4 .   ? 28.212  31.634  13.176 1.00 85.51  ? 989  HOH A O     1 ? 
HETATM 4949 O O     . HOH E 4 .   ? 21.616  16.853  29.947 1.00 77.88  ? 990  HOH A O     1 ? 
HETATM 4950 O O     . HOH E 4 .   ? 27.743  30.498  10.431 1.00 85.75  ? 991  HOH A O     1 ? 
HETATM 4951 O O     . HOH E 4 .   ? 31.412  -19.720 29.119 1.00 71.65  ? 992  HOH A O     1 ? 
HETATM 4952 O O     . HOH E 4 .   ? -0.071  -2.447  65.233 1.00 82.22  ? 993  HOH A O     1 ? 
HETATM 4953 O O     . HOH E 4 .   ? -6.025  17.769  18.566 1.00 80.88  ? 994  HOH A O     1 ? 
HETATM 4954 O O     . HOH E 4 .   ? 7.447   20.221  14.094 1.00 78.92  ? 995  HOH A O     1 ? 
HETATM 4955 O O     . HOH E 4 .   ? 28.246  15.424  50.854 1.00 78.11  ? 996  HOH A O     1 ? 
HETATM 4956 O O     . HOH E 4 .   ? -10.405 -33.030 22.696 1.00 76.57  ? 997  HOH A O     1 ? 
HETATM 4957 O O     . HOH E 4 .   ? 18.466  -4.508  60.987 1.00 77.66  ? 998  HOH A O     1 ? 
HETATM 4958 O O     . HOH E 4 .   ? -3.174  18.312  4.412  1.00 89.50  ? 999  HOH A O     1 ? 
HETATM 4959 O O     . HOH E 4 .   ? 27.238  -1.834  10.647 1.00 88.96  ? 1000 HOH A O     1 ? 
HETATM 4960 O O     . HOH E 4 .   ? 23.511  24.997  53.460 1.00 76.83  ? 1001 HOH A O     1 ? 
HETATM 4961 O O     . HOH E 4 .   ? 40.257  -10.548 32.454 1.00 80.79  ? 1002 HOH A O     1 ? 
HETATM 4962 O O     . HOH E 4 .   ? -2.814  20.256  30.071 1.00 92.47  ? 1003 HOH A O     1 ? 
HETATM 4963 O O     . HOH E 4 .   ? 21.647  -6.858  56.623 1.00 68.20  ? 1004 HOH A O     1 ? 
HETATM 4964 O O     . HOH E 4 .   ? 0.265   -36.365 3.650  1.00 94.90  ? 1005 HOH A O     1 ? 
HETATM 4965 O O     . HOH E 4 .   ? 11.038  20.094  4.526  1.00 73.81  ? 1006 HOH A O     1 ? 
HETATM 4966 O O     . HOH E 4 .   ? 23.375  18.415  47.368 1.00 69.62  ? 1007 HOH A O     1 ? 
HETATM 4967 O O     . HOH E 4 .   ? -15.024 2.033   -0.554 1.00 63.78  ? 1008 HOH A O     1 ? 
HETATM 4968 O O     . HOH E 4 .   ? 26.163  17.015  48.834 1.00 65.78  ? 1009 HOH A O     1 ? 
HETATM 4969 O O     . HOH E 4 .   ? 37.105  13.536  46.398 1.00 84.28  ? 1010 HOH A O     1 ? 
# 
