data_8T1W
# 
_entry.id   8T1W 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8T1W         pdb_00008t1w 10.2210/pdb8t1w/pdb 
WWPDB D_1000275044 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-12-04 
2 'Structure model' 1 1 2024-12-18 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'      
2 2 'Structure model' 'Database references'  
3 2 'Structure model' 'Derived calculations' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation                  
2 2 'Structure model' citation_author           
3 2 'Structure model' pdbx_struct_assembly      
4 2 'Structure model' pdbx_struct_assembly_gen  
5 2 'Structure model' pdbx_struct_assembly_prop 
6 2 'Structure model' pdbx_struct_oper_list     
7 2 'Structure model' struct_biol               
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.journal_volume'                  
2  2 'Structure model' '_citation.page_first'                      
3  2 'Structure model' '_citation.page_last'                       
4  2 'Structure model' '_citation.pdbx_database_id_PubMed'         
5  2 'Structure model' '_citation.title'                           
6  2 'Structure model' '_citation_author.identifier_ORCID'         
7  2 'Structure model' '_citation_author.name'                     
8  2 'Structure model' '_pdbx_struct_assembly.details'             
9  2 'Structure model' '_pdbx_struct_assembly.method_details'      
10 2 'Structure model' '_pdbx_struct_assembly.oligomeric_count'    
11 2 'Structure model' '_pdbx_struct_assembly.oligomeric_details'  
12 2 'Structure model' '_pdbx_struct_assembly_gen.oper_expression' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8T1W 
_pdbx_database_status.recvd_initial_deposition_date   2023-06-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              cherezov@usc.edu 
_pdbx_contact_author.name_first         Vadim 
_pdbx_contact_author.name_last          Cherezov 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5265-3914 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Barekatain, M.'   1  ? 
'Johansson, L.'    2  ? 
'Lam, J.H.'        3  ? 
'Sadybekov, A.V.'  4  ? 
'Han, G.W.'        5  ? 
'Popov, P.'        6  ? 
'Russo, J.'        7  ? 
'Bliesath, J.'     8  ? 
'Brice, N.'        9  ? 
'Beresford, M.'    10 ? 
'Carlson, L.'      11 ? 
'Saikatendu, K.S.' 12 ? 
'Sun, H.'          13 ? 
'Murphy, S.'       14 ? 
'Monenschein, H.'  15 ? 
'Schiffer, H.H.'   16 ? 
'Lutomski, C.'     17 ? 
'Robinson, C.V.'   18 ? 
'Liu, Z.'          19 ? 
'Hua, T.'          20 ? 
'Katritch, V.'     21 ? 
'Cherezov, V.'     22 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Sci.Signal. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1937-9145 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            17 
_citation.language                  ? 
_citation.page_first                eado8741 
_citation.page_last                 eado8741 
_citation.title                     
;Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/scisignal.ado8741 
_citation.pdbx_database_id_PubMed   39626010 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Barekatain, M.'   1  0000-0003-4178-684X 
primary 'Johansson, L.C.'  2  ?                   
primary 'Lam, J.H.'        3  0000-0002-5496-6228 
primary 'Chang, H.'        4  0000-0003-1684-8201 
primary 'Sadybekov, A.V.'  5  0000-0003-3925-983X 
primary 'Han, G.W.'        6  0000-0003-4107-835X 
primary 'Russo, J.'        7  ?                   
primary 'Bliesath, J.'     8  ?                   
primary 'Brice, N.L.'      9  ?                   
primary 'Carlton, M.B.L.'  10 ?                   
primary 'Saikatendu, K.S.' 11 0000-0001-6734-237X 
primary 'Sun, H.'          12 ?                   
primary 'Murphy, S.T.'     13 0009-0000-5404-6512 
primary 'Monenschein, H.'  14 ?                   
primary 'Schiffer, H.H.'   15 ?                   
primary 'Popov, P.'        16 ?                   
primary 'Lutomski, C.A.'   17 0000-0001-7509-103X 
primary 'Robinson, C.V.'   18 0000-0001-7829-5505 
primary 'Liu, Z.J.'        19 0000-0001-7279-2893 
primary 'Hua, T.'          20 0000-0002-6132-2068 
primary 'Katritch, V.'     21 0000-0003-3883-4505 
primary 'Cherezov, V.'     22 0000-0002-5265-3914 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'G-protein coupled receptor 6, Soluble cytochrome b562 chimera' 49715.480 1 ? ? ? ? 
2 non-polymer syn 
'1-{2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl}ethan-1-one' 
473.516   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Sphingosine 1-phosphate receptor GPR6,Cytochrome b-562' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKTIIALSYIFCLVFADYKDDDDAGRAGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIAST
PALRTPMFVLVGSLATADLLAGLGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNPLTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAADLE
DNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKV
KEAQAAAEQLKTTRNAYIQKYLAHLAATRKGVRTLAVVLGTFGACWLPFAIYCVVGSHEDPAVYTYATLLPATLNSMINP
IIYAFRNQEIQRALWLLLDGCFQSKVPFRSRSPSEVEFLEVLFQGPHHHHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKTIIALSYIFCLVFADYKDDDDAGRAGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIAST
PALRTPMFVLVGSLATADLLAGLGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNPLTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAADLE
DNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKV
KEAQAAAEQLKTTRNAYIQKYLAHLAATRKGVRTLAVVLGTFGACWLPFAIYCVVGSHEDPAVYTYATLLPATLNSMINP
IIYAFRNQEIQRALWLLLDGCFQSKVPFRSRSPSEVEFLEVLFQGPHHHHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        
'1-{2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl}ethan-1-one' 
_pdbx_entity_nonpoly.comp_id     X7T 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   THR n 
1 4   ILE n 
1 5   ILE n 
1 6   ALA n 
1 7   LEU n 
1 8   SER n 
1 9   TYR n 
1 10  ILE n 
1 11  PHE n 
1 12  CYS n 
1 13  LEU n 
1 14  VAL n 
1 15  PHE n 
1 16  ALA n 
1 17  ASP n 
1 18  TYR n 
1 19  LYS n 
1 20  ASP n 
1 21  ASP n 
1 22  ASP n 
1 23  ASP n 
1 24  ALA n 
1 25  GLY n 
1 26  ARG n 
1 27  ALA n 
1 28  GLY n 
1 29  GLY n 
1 30  ALA n 
1 31  ASN n 
1 32  GLY n 
1 33  SER n 
1 34  LEU n 
1 35  GLU n 
1 36  LEU n 
1 37  SER n 
1 38  SER n 
1 39  GLN n 
1 40  LEU n 
1 41  SER n 
1 42  ALA n 
1 43  GLY n 
1 44  PRO n 
1 45  PRO n 
1 46  GLY n 
1 47  LEU n 
1 48  LEU n 
1 49  LEU n 
1 50  PRO n 
1 51  ALA n 
1 52  VAL n 
1 53  ASN n 
1 54  PRO n 
1 55  TRP n 
1 56  ASP n 
1 57  VAL n 
1 58  LEU n 
1 59  LEU n 
1 60  CYS n 
1 61  VAL n 
1 62  SER n 
1 63  GLY n 
1 64  THR n 
1 65  VAL n 
1 66  ILE n 
1 67  ALA n 
1 68  GLY n 
1 69  GLU n 
1 70  ASN n 
1 71  ALA n 
1 72  LEU n 
1 73  VAL n 
1 74  VAL n 
1 75  ALA n 
1 76  LEU n 
1 77  ILE n 
1 78  ALA n 
1 79  SER n 
1 80  THR n 
1 81  PRO n 
1 82  ALA n 
1 83  LEU n 
1 84  ARG n 
1 85  THR n 
1 86  PRO n 
1 87  MET n 
1 88  PHE n 
1 89  VAL n 
1 90  LEU n 
1 91  VAL n 
1 92  GLY n 
1 93  SER n 
1 94  LEU n 
1 95  ALA n 
1 96  THR n 
1 97  ALA n 
1 98  ASP n 
1 99  LEU n 
1 100 LEU n 
1 101 ALA n 
1 102 GLY n 
1 103 LEU n 
1 104 GLY n 
1 105 LEU n 
1 106 ILE n 
1 107 LEU n 
1 108 HIS n 
1 109 PHE n 
1 110 VAL n 
1 111 PHE n 
1 112 GLN n 
1 113 TYR n 
1 114 LEU n 
1 115 VAL n 
1 116 PRO n 
1 117 SER n 
1 118 GLU n 
1 119 THR n 
1 120 VAL n 
1 121 SER n 
1 122 LEU n 
1 123 LEU n 
1 124 THR n 
1 125 VAL n 
1 126 GLY n 
1 127 PHE n 
1 128 LEU n 
1 129 VAL n 
1 130 ALA n 
1 131 SER n 
1 132 PHE n 
1 133 ALA n 
1 134 ALA n 
1 135 SER n 
1 136 VAL n 
1 137 SER n 
1 138 SER n 
1 139 LEU n 
1 140 LEU n 
1 141 ALA n 
1 142 ILE n 
1 143 THR n 
1 144 VAL n 
1 145 ASP n 
1 146 ARG n 
1 147 TYR n 
1 148 LEU n 
1 149 SER n 
1 150 LEU n 
1 151 TYR n 
1 152 ASN n 
1 153 PRO n 
1 154 LEU n 
1 155 THR n 
1 156 TYR n 
1 157 TYR n 
1 158 SER n 
1 159 ARG n 
1 160 ARG n 
1 161 THR n 
1 162 LEU n 
1 163 LEU n 
1 164 GLY n 
1 165 VAL n 
1 166 HIS n 
1 167 LEU n 
1 168 LEU n 
1 169 LEU n 
1 170 ALA n 
1 171 ALA n 
1 172 THR n 
1 173 TRP n 
1 174 THR n 
1 175 VAL n 
1 176 SER n 
1 177 LEU n 
1 178 GLY n 
1 179 LEU n 
1 180 GLY n 
1 181 LEU n 
1 182 LEU n 
1 183 PRO n 
1 184 VAL n 
1 185 LEU n 
1 186 GLY n 
1 187 TRP n 
1 188 ASN n 
1 189 CYS n 
1 190 LEU n 
1 191 ALA n 
1 192 GLU n 
1 193 ARG n 
1 194 ALA n 
1 195 ALA n 
1 196 CYS n 
1 197 SER n 
1 198 VAL n 
1 199 VAL n 
1 200 ARG n 
1 201 PRO n 
1 202 LEU n 
1 203 ALA n 
1 204 ARG n 
1 205 SER n 
1 206 HIS n 
1 207 VAL n 
1 208 ALA n 
1 209 LEU n 
1 210 LEU n 
1 211 SER n 
1 212 ALA n 
1 213 ALA n 
1 214 PHE n 
1 215 PHE n 
1 216 MET n 
1 217 VAL n 
1 218 PHE n 
1 219 GLY n 
1 220 ILE n 
1 221 MET n 
1 222 LEU n 
1 223 HIS n 
1 224 LEU n 
1 225 TYR n 
1 226 VAL n 
1 227 ARG n 
1 228 ILE n 
1 229 CYS n 
1 230 GLN n 
1 231 VAL n 
1 232 VAL n 
1 233 TRP n 
1 234 ARG n 
1 235 HIS n 
1 236 ALA n 
1 237 ALA n 
1 238 ASP n 
1 239 LEU n 
1 240 GLU n 
1 241 ASP n 
1 242 ASN n 
1 243 TRP n 
1 244 GLU n 
1 245 THR n 
1 246 LEU n 
1 247 ASN n 
1 248 ASP n 
1 249 ASN n 
1 250 LEU n 
1 251 LYS n 
1 252 VAL n 
1 253 ILE n 
1 254 GLU n 
1 255 LYS n 
1 256 ALA n 
1 257 ASP n 
1 258 ASN n 
1 259 ALA n 
1 260 ALA n 
1 261 GLN n 
1 262 VAL n 
1 263 LYS n 
1 264 ASP n 
1 265 ALA n 
1 266 LEU n 
1 267 THR n 
1 268 LYS n 
1 269 MET n 
1 270 ARG n 
1 271 ALA n 
1 272 ALA n 
1 273 ALA n 
1 274 LEU n 
1 275 ASP n 
1 276 ALA n 
1 277 GLN n 
1 278 LYS n 
1 279 ALA n 
1 280 THR n 
1 281 PRO n 
1 282 PRO n 
1 283 LYS n 
1 284 LEU n 
1 285 GLU n 
1 286 ASP n 
1 287 LYS n 
1 288 SER n 
1 289 PRO n 
1 290 ASP n 
1 291 SER n 
1 292 PRO n 
1 293 GLU n 
1 294 MET n 
1 295 LYS n 
1 296 ASP n 
1 297 PHE n 
1 298 ARG n 
1 299 HIS n 
1 300 GLY n 
1 301 PHE n 
1 302 ASP n 
1 303 ILE n 
1 304 LEU n 
1 305 VAL n 
1 306 GLY n 
1 307 GLN n 
1 308 ILE n 
1 309 ASP n 
1 310 ASP n 
1 311 ALA n 
1 312 LEU n 
1 313 LYS n 
1 314 LEU n 
1 315 ALA n 
1 316 ASN n 
1 317 GLU n 
1 318 GLY n 
1 319 LYS n 
1 320 VAL n 
1 321 LYS n 
1 322 GLU n 
1 323 ALA n 
1 324 GLN n 
1 325 ALA n 
1 326 ALA n 
1 327 ALA n 
1 328 GLU n 
1 329 GLN n 
1 330 LEU n 
1 331 LYS n 
1 332 THR n 
1 333 THR n 
1 334 ARG n 
1 335 ASN n 
1 336 ALA n 
1 337 TYR n 
1 338 ILE n 
1 339 GLN n 
1 340 LYS n 
1 341 TYR n 
1 342 LEU n 
1 343 ALA n 
1 344 HIS n 
1 345 LEU n 
1 346 ALA n 
1 347 ALA n 
1 348 THR n 
1 349 ARG n 
1 350 LYS n 
1 351 GLY n 
1 352 VAL n 
1 353 ARG n 
1 354 THR n 
1 355 LEU n 
1 356 ALA n 
1 357 VAL n 
1 358 VAL n 
1 359 LEU n 
1 360 GLY n 
1 361 THR n 
1 362 PHE n 
1 363 GLY n 
1 364 ALA n 
1 365 CYS n 
1 366 TRP n 
1 367 LEU n 
1 368 PRO n 
1 369 PHE n 
1 370 ALA n 
1 371 ILE n 
1 372 TYR n 
1 373 CYS n 
1 374 VAL n 
1 375 VAL n 
1 376 GLY n 
1 377 SER n 
1 378 HIS n 
1 379 GLU n 
1 380 ASP n 
1 381 PRO n 
1 382 ALA n 
1 383 VAL n 
1 384 TYR n 
1 385 THR n 
1 386 TYR n 
1 387 ALA n 
1 388 THR n 
1 389 LEU n 
1 390 LEU n 
1 391 PRO n 
1 392 ALA n 
1 393 THR n 
1 394 LEU n 
1 395 ASN n 
1 396 SER n 
1 397 MET n 
1 398 ILE n 
1 399 ASN n 
1 400 PRO n 
1 401 ILE n 
1 402 ILE n 
1 403 TYR n 
1 404 ALA n 
1 405 PHE n 
1 406 ARG n 
1 407 ASN n 
1 408 GLN n 
1 409 GLU n 
1 410 ILE n 
1 411 GLN n 
1 412 ARG n 
1 413 ALA n 
1 414 LEU n 
1 415 TRP n 
1 416 LEU n 
1 417 LEU n 
1 418 LEU n 
1 419 ASP n 
1 420 GLY n 
1 421 CYS n 
1 422 PHE n 
1 423 GLN n 
1 424 SER n 
1 425 LYS n 
1 426 VAL n 
1 427 PRO n 
1 428 PHE n 
1 429 ARG n 
1 430 SER n 
1 431 ARG n 
1 432 SER n 
1 433 PRO n 
1 434 SER n 
1 435 GLU n 
1 436 VAL n 
1 437 GLU n 
1 438 PHE n 
1 439 LEU n 
1 440 GLU n 
1 441 VAL n 
1 442 LEU n 
1 443 PHE n 
1 444 GLN n 
1 445 GLY n 
1 446 PRO n 
1 447 HIS n 
1 448 HIS n 
1 449 HIS n 
1 450 HIS n 
1 451 HIS n 
1 452 HIS n 
1 453 HIS n 
1 454 HIS n 
1 455 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   236 human ? GPR6 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? human 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 237 343 ?     ? cybC ? ? ? ? ? ? 'Escherichia coli' 562  ? ? ? ? ? ? ? human 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 344 455 human ? GPR6 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? human 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'       133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'   156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'    149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'      165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'      181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'      117.146 
X7T non-polymer         . 
'1-{2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl}ethan-1-one' ? 
'C24 H29 F2 N5 O3' 473.516 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   21   ?    ?   ?   A . n 
A 1 2   LYS 2   22   ?    ?   ?   A . n 
A 1 3   THR 3   23   ?    ?   ?   A . n 
A 1 4   ILE 4   24   ?    ?   ?   A . n 
A 1 5   ILE 5   25   ?    ?   ?   A . n 
A 1 6   ALA 6   26   ?    ?   ?   A . n 
A 1 7   LEU 7   27   ?    ?   ?   A . n 
A 1 8   SER 8   28   ?    ?   ?   A . n 
A 1 9   TYR 9   29   ?    ?   ?   A . n 
A 1 10  ILE 10  30   ?    ?   ?   A . n 
A 1 11  PHE 11  31   ?    ?   ?   A . n 
A 1 12  CYS 12  32   ?    ?   ?   A . n 
A 1 13  LEU 13  33   ?    ?   ?   A . n 
A 1 14  VAL 14  34   ?    ?   ?   A . n 
A 1 15  PHE 15  35   ?    ?   ?   A . n 
A 1 16  ALA 16  36   ?    ?   ?   A . n 
A 1 17  ASP 17  37   ?    ?   ?   A . n 
A 1 18  TYR 18  38   ?    ?   ?   A . n 
A 1 19  LYS 19  39   ?    ?   ?   A . n 
A 1 20  ASP 20  40   ?    ?   ?   A . n 
A 1 21  ASP 21  41   ?    ?   ?   A . n 
A 1 22  ASP 22  42   ?    ?   ?   A . n 
A 1 23  ASP 23  43   ?    ?   ?   A . n 
A 1 24  ALA 24  44   ?    ?   ?   A . n 
A 1 25  GLY 25  45   ?    ?   ?   A . n 
A 1 26  ARG 26  46   ?    ?   ?   A . n 
A 1 27  ALA 27  47   ?    ?   ?   A . n 
A 1 28  GLY 28  48   ?    ?   ?   A . n 
A 1 29  GLY 29  49   ?    ?   ?   A . n 
A 1 30  ALA 30  50   ?    ?   ?   A . n 
A 1 31  ASN 31  51   ?    ?   ?   A . n 
A 1 32  GLY 32  52   ?    ?   ?   A . n 
A 1 33  SER 33  53   ?    ?   ?   A . n 
A 1 34  LEU 34  54   ?    ?   ?   A . n 
A 1 35  GLU 35  55   ?    ?   ?   A . n 
A 1 36  LEU 36  56   ?    ?   ?   A . n 
A 1 37  SER 37  57   ?    ?   ?   A . n 
A 1 38  SER 38  58   ?    ?   ?   A . n 
A 1 39  GLN 39  59   ?    ?   ?   A . n 
A 1 40  LEU 40  60   ?    ?   ?   A . n 
A 1 41  SER 41  61   ?    ?   ?   A . n 
A 1 42  ALA 42  62   ?    ?   ?   A . n 
A 1 43  GLY 43  63   ?    ?   ?   A . n 
A 1 44  PRO 44  64   ?    ?   ?   A . n 
A 1 45  PRO 45  65   ?    ?   ?   A . n 
A 1 46  GLY 46  66   ?    ?   ?   A . n 
A 1 47  LEU 47  67   ?    ?   ?   A . n 
A 1 48  LEU 48  68   ?    ?   ?   A . n 
A 1 49  LEU 49  69   69   LEU LEU A . n 
A 1 50  PRO 50  70   70   PRO PRO A . n 
A 1 51  ALA 51  71   71   ALA ALA A . n 
A 1 52  VAL 52  72   72   VAL VAL A . n 
A 1 53  ASN 53  73   73   ASN ASN A . n 
A 1 54  PRO 54  74   74   PRO PRO A . n 
A 1 55  TRP 55  75   75   TRP TRP A . n 
A 1 56  ASP 56  76   76   ASP ASP A . n 
A 1 57  VAL 57  77   77   VAL VAL A . n 
A 1 58  LEU 58  78   78   LEU LEU A . n 
A 1 59  LEU 59  79   79   LEU LEU A . n 
A 1 60  CYS 60  80   80   CYS CYS A . n 
A 1 61  VAL 61  81   81   VAL VAL A . n 
A 1 62  SER 62  82   82   SER SER A . n 
A 1 63  GLY 63  83   83   GLY GLY A . n 
A 1 64  THR 64  84   84   THR THR A . n 
A 1 65  VAL 65  85   85   VAL VAL A . n 
A 1 66  ILE 66  86   86   ILE ILE A . n 
A 1 67  ALA 67  87   87   ALA ALA A . n 
A 1 68  GLY 68  88   88   GLY GLY A . n 
A 1 69  GLU 69  89   89   GLU GLU A . n 
A 1 70  ASN 70  90   90   ASN ASN A . n 
A 1 71  ALA 71  91   91   ALA ALA A . n 
A 1 72  LEU 72  92   92   LEU LEU A . n 
A 1 73  VAL 73  93   93   VAL VAL A . n 
A 1 74  VAL 74  94   94   VAL VAL A . n 
A 1 75  ALA 75  95   95   ALA ALA A . n 
A 1 76  LEU 76  96   96   LEU LEU A . n 
A 1 77  ILE 77  97   97   ILE ILE A . n 
A 1 78  ALA 78  98   98   ALA ALA A . n 
A 1 79  SER 79  99   99   SER SER A . n 
A 1 80  THR 80  100  100  THR THR A . n 
A 1 81  PRO 81  101  101  PRO PRO A . n 
A 1 82  ALA 82  102  102  ALA ALA A . n 
A 1 83  LEU 83  103  103  LEU LEU A . n 
A 1 84  ARG 84  104  104  ARG ARG A . n 
A 1 85  THR 85  105  105  THR THR A . n 
A 1 86  PRO 86  106  106  PRO PRO A . n 
A 1 87  MET 87  107  107  MET MET A . n 
A 1 88  PHE 88  108  108  PHE PHE A . n 
A 1 89  VAL 89  109  109  VAL VAL A . n 
A 1 90  LEU 90  110  110  LEU LEU A . n 
A 1 91  VAL 91  111  111  VAL VAL A . n 
A 1 92  GLY 92  112  112  GLY GLY A . n 
A 1 93  SER 93  113  113  SER SER A . n 
A 1 94  LEU 94  114  114  LEU LEU A . n 
A 1 95  ALA 95  115  115  ALA ALA A . n 
A 1 96  THR 96  116  116  THR THR A . n 
A 1 97  ALA 97  117  117  ALA ALA A . n 
A 1 98  ASP 98  118  118  ASP ASP A . n 
A 1 99  LEU 99  119  119  LEU LEU A . n 
A 1 100 LEU 100 120  120  LEU LEU A . n 
A 1 101 ALA 101 121  121  ALA ALA A . n 
A 1 102 GLY 102 122  122  GLY GLY A . n 
A 1 103 LEU 103 123  123  LEU LEU A . n 
A 1 104 GLY 104 124  124  GLY GLY A . n 
A 1 105 LEU 105 125  125  LEU LEU A . n 
A 1 106 ILE 106 126  126  ILE ILE A . n 
A 1 107 LEU 107 127  127  LEU LEU A . n 
A 1 108 HIS 108 128  128  HIS HIS A . n 
A 1 109 PHE 109 129  129  PHE PHE A . n 
A 1 110 VAL 110 130  130  VAL VAL A . n 
A 1 111 PHE 111 131  131  PHE PHE A . n 
A 1 112 GLN 112 132  132  GLN GLN A . n 
A 1 113 TYR 113 133  133  TYR TYR A . n 
A 1 114 LEU 114 134  134  LEU LEU A . n 
A 1 115 VAL 115 135  135  VAL VAL A . n 
A 1 116 PRO 116 136  136  PRO PRO A . n 
A 1 117 SER 117 137  137  SER SER A . n 
A 1 118 GLU 118 138  138  GLU GLU A . n 
A 1 119 THR 119 139  139  THR THR A . n 
A 1 120 VAL 120 140  140  VAL VAL A . n 
A 1 121 SER 121 141  141  SER SER A . n 
A 1 122 LEU 122 142  142  LEU LEU A . n 
A 1 123 LEU 123 143  143  LEU LEU A . n 
A 1 124 THR 124 144  144  THR THR A . n 
A 1 125 VAL 125 145  145  VAL VAL A . n 
A 1 126 GLY 126 146  146  GLY GLY A . n 
A 1 127 PHE 127 147  147  PHE PHE A . n 
A 1 128 LEU 128 148  148  LEU LEU A . n 
A 1 129 VAL 129 149  149  VAL VAL A . n 
A 1 130 ALA 130 150  150  ALA ALA A . n 
A 1 131 SER 131 151  151  SER SER A . n 
A 1 132 PHE 132 152  152  PHE PHE A . n 
A 1 133 ALA 133 153  153  ALA ALA A . n 
A 1 134 ALA 134 154  154  ALA ALA A . n 
A 1 135 SER 135 155  155  SER SER A . n 
A 1 136 VAL 136 156  156  VAL VAL A . n 
A 1 137 SER 137 157  157  SER SER A . n 
A 1 138 SER 138 158  158  SER SER A . n 
A 1 139 LEU 139 159  159  LEU LEU A . n 
A 1 140 LEU 140 160  160  LEU LEU A . n 
A 1 141 ALA 141 161  161  ALA ALA A . n 
A 1 142 ILE 142 162  162  ILE ILE A . n 
A 1 143 THR 143 163  163  THR THR A . n 
A 1 144 VAL 144 164  164  VAL VAL A . n 
A 1 145 ASP 145 165  165  ASP ASP A . n 
A 1 146 ARG 146 166  166  ARG ARG A . n 
A 1 147 TYR 147 167  167  TYR TYR A . n 
A 1 148 LEU 148 168  168  LEU LEU A . n 
A 1 149 SER 149 169  169  SER SER A . n 
A 1 150 LEU 150 170  170  LEU LEU A . n 
A 1 151 TYR 151 171  171  TYR TYR A . n 
A 1 152 ASN 152 172  172  ASN ASN A . n 
A 1 153 PRO 153 173  173  PRO PRO A . n 
A 1 154 LEU 154 174  174  LEU LEU A . n 
A 1 155 THR 155 175  175  THR THR A . n 
A 1 156 TYR 156 176  176  TYR TYR A . n 
A 1 157 TYR 157 177  177  TYR TYR A . n 
A 1 158 SER 158 178  178  SER SER A . n 
A 1 159 ARG 159 179  179  ARG ARG A . n 
A 1 160 ARG 160 180  180  ARG ARG A . n 
A 1 161 THR 161 181  181  THR THR A . n 
A 1 162 LEU 162 182  182  LEU LEU A . n 
A 1 163 LEU 163 183  183  LEU LEU A . n 
A 1 164 GLY 164 184  184  GLY GLY A . n 
A 1 165 VAL 165 185  185  VAL VAL A . n 
A 1 166 HIS 166 186  186  HIS HIS A . n 
A 1 167 LEU 167 187  187  LEU LEU A . n 
A 1 168 LEU 168 188  188  LEU LEU A . n 
A 1 169 LEU 169 189  189  LEU LEU A . n 
A 1 170 ALA 170 190  190  ALA ALA A . n 
A 1 171 ALA 171 191  191  ALA ALA A . n 
A 1 172 THR 172 192  192  THR THR A . n 
A 1 173 TRP 173 193  193  TRP TRP A . n 
A 1 174 THR 174 194  194  THR THR A . n 
A 1 175 VAL 175 195  195  VAL VAL A . n 
A 1 176 SER 176 196  196  SER SER A . n 
A 1 177 LEU 177 197  197  LEU LEU A . n 
A 1 178 GLY 178 198  198  GLY GLY A . n 
A 1 179 LEU 179 199  199  LEU LEU A . n 
A 1 180 GLY 180 200  200  GLY GLY A . n 
A 1 181 LEU 181 201  201  LEU LEU A . n 
A 1 182 LEU 182 202  202  LEU LEU A . n 
A 1 183 PRO 183 203  203  PRO PRO A . n 
A 1 184 VAL 184 204  204  VAL VAL A . n 
A 1 185 LEU 185 205  205  LEU LEU A . n 
A 1 186 GLY 186 206  206  GLY GLY A . n 
A 1 187 TRP 187 207  207  TRP TRP A . n 
A 1 188 ASN 188 208  208  ASN ASN A . n 
A 1 189 CYS 189 209  209  CYS CYS A . n 
A 1 190 LEU 190 210  210  LEU LEU A . n 
A 1 191 ALA 191 211  211  ALA ALA A . n 
A 1 192 GLU 192 212  212  GLU GLU A . n 
A 1 193 ARG 193 213  213  ARG ARG A . n 
A 1 194 ALA 194 214  214  ALA ALA A . n 
A 1 195 ALA 195 215  215  ALA ALA A . n 
A 1 196 CYS 196 216  216  CYS CYS A . n 
A 1 197 SER 197 217  217  SER SER A . n 
A 1 198 VAL 198 218  218  VAL VAL A . n 
A 1 199 VAL 199 219  219  VAL VAL A . n 
A 1 200 ARG 200 220  220  ARG ARG A . n 
A 1 201 PRO 201 221  221  PRO PRO A . n 
A 1 202 LEU 202 222  222  LEU LEU A . n 
A 1 203 ALA 203 223  223  ALA ALA A . n 
A 1 204 ARG 204 224  224  ARG ARG A . n 
A 1 205 SER 205 225  225  SER SER A . n 
A 1 206 HIS 206 226  226  HIS HIS A . n 
A 1 207 VAL 207 227  227  VAL VAL A . n 
A 1 208 ALA 208 228  228  ALA ALA A . n 
A 1 209 LEU 209 229  229  LEU LEU A . n 
A 1 210 LEU 210 230  230  LEU LEU A . n 
A 1 211 SER 211 231  231  SER SER A . n 
A 1 212 ALA 212 232  232  ALA ALA A . n 
A 1 213 ALA 213 233  233  ALA ALA A . n 
A 1 214 PHE 214 234  234  PHE PHE A . n 
A 1 215 PHE 215 235  235  PHE PHE A . n 
A 1 216 MET 216 236  236  MET MET A . n 
A 1 217 VAL 217 237  237  VAL VAL A . n 
A 1 218 PHE 218 238  238  PHE PHE A . n 
A 1 219 GLY 219 239  239  GLY GLY A . n 
A 1 220 ILE 220 240  240  ILE ILE A . n 
A 1 221 MET 221 241  241  MET MET A . n 
A 1 222 LEU 222 242  242  LEU LEU A . n 
A 1 223 HIS 223 243  243  HIS HIS A . n 
A 1 224 LEU 224 244  244  LEU LEU A . n 
A 1 225 TYR 225 245  245  TYR TYR A . n 
A 1 226 VAL 226 246  246  VAL VAL A . n 
A 1 227 ARG 227 247  247  ARG ARG A . n 
A 1 228 ILE 228 248  248  ILE ILE A . n 
A 1 229 CYS 229 249  249  CYS CYS A . n 
A 1 230 GLN 230 250  250  GLN GLN A . n 
A 1 231 VAL 231 251  251  VAL VAL A . n 
A 1 232 VAL 232 252  252  VAL VAL A . n 
A 1 233 TRP 233 253  253  TRP TRP A . n 
A 1 234 ARG 234 254  254  ARG ARG A . n 
A 1 235 HIS 235 255  255  HIS HIS A . n 
A 1 236 ALA 236 256  256  ALA ALA A . n 
A 1 237 ALA 237 1001 1001 ALA ALA A . n 
A 1 238 ASP 238 1002 1002 ASP ASP A . n 
A 1 239 LEU 239 1003 1003 LEU LEU A . n 
A 1 240 GLU 240 1004 1004 GLU GLU A . n 
A 1 241 ASP 241 1005 1005 ASP ASP A . n 
A 1 242 ASN 242 1006 1006 ASN ASN A . n 
A 1 243 TRP 243 1007 1007 TRP TRP A . n 
A 1 244 GLU 244 1008 1008 GLU GLU A . n 
A 1 245 THR 245 1009 1009 THR THR A . n 
A 1 246 LEU 246 1010 1010 LEU LEU A . n 
A 1 247 ASN 247 1011 1011 ASN ASN A . n 
A 1 248 ASP 248 1012 1012 ASP ASP A . n 
A 1 249 ASN 249 1013 1013 ASN ASN A . n 
A 1 250 LEU 250 1014 1014 LEU LEU A . n 
A 1 251 LYS 251 1015 1015 LYS LYS A . n 
A 1 252 VAL 252 1016 1016 VAL VAL A . n 
A 1 253 ILE 253 1017 1017 ILE ILE A . n 
A 1 254 GLU 254 1018 1018 GLU GLU A . n 
A 1 255 LYS 255 1019 1019 LYS LYS A . n 
A 1 256 ALA 256 1020 1020 ALA ALA A . n 
A 1 257 ASP 257 1021 1021 ASP ASP A . n 
A 1 258 ASN 258 1022 1022 ASN ASN A . n 
A 1 259 ALA 259 1023 1023 ALA ALA A . n 
A 1 260 ALA 260 1024 1024 ALA ALA A . n 
A 1 261 GLN 261 1025 1025 GLN GLN A . n 
A 1 262 VAL 262 1026 1026 VAL VAL A . n 
A 1 263 LYS 263 1027 1027 LYS LYS A . n 
A 1 264 ASP 264 1028 1028 ASP ASP A . n 
A 1 265 ALA 265 1029 1029 ALA ALA A . n 
A 1 266 LEU 266 1030 1030 LEU LEU A . n 
A 1 267 THR 267 1031 1031 THR THR A . n 
A 1 268 LYS 268 1032 1032 LYS LYS A . n 
A 1 269 MET 269 1033 1033 MET MET A . n 
A 1 270 ARG 270 1034 1034 ARG ARG A . n 
A 1 271 ALA 271 1035 1035 ALA ALA A . n 
A 1 272 ALA 272 1036 1036 ALA ALA A . n 
A 1 273 ALA 273 1037 1037 ALA ALA A . n 
A 1 274 LEU 274 1038 1038 LEU LEU A . n 
A 1 275 ASP 275 1039 1039 ASP ASP A . n 
A 1 276 ALA 276 1040 1040 ALA ALA A . n 
A 1 277 GLN 277 1041 1041 GLN GLN A . n 
A 1 278 LYS 278 1042 1042 LYS LYS A . n 
A 1 279 ALA 279 1043 1043 ALA ALA A . n 
A 1 280 THR 280 1044 1044 THR THR A . n 
A 1 281 PRO 281 1045 1045 PRO PRO A . n 
A 1 282 PRO 282 1046 1046 PRO PRO A . n 
A 1 283 LYS 283 1047 ?    ?   ?   A . n 
A 1 284 LEU 284 1048 ?    ?   ?   A . n 
A 1 285 GLU 285 1049 ?    ?   ?   A . n 
A 1 286 ASP 286 1050 ?    ?   ?   A . n 
A 1 287 LYS 287 1051 ?    ?   ?   A . n 
A 1 288 SER 288 1052 ?    ?   ?   A . n 
A 1 289 PRO 289 1053 ?    ?   ?   A . n 
A 1 290 ASP 290 1054 ?    ?   ?   A . n 
A 1 291 SER 291 1055 ?    ?   ?   A . n 
A 1 292 PRO 292 1056 ?    ?   ?   A . n 
A 1 293 GLU 293 1057 ?    ?   ?   A . n 
A 1 294 MET 294 1058 ?    ?   ?   A . n 
A 1 295 LYS 295 1059 ?    ?   ?   A . n 
A 1 296 ASP 296 1060 ?    ?   ?   A . n 
A 1 297 PHE 297 1061 ?    ?   ?   A . n 
A 1 298 ARG 298 1062 ?    ?   ?   A . n 
A 1 299 HIS 299 1063 1063 HIS HIS A . n 
A 1 300 GLY 300 1064 1064 GLY GLY A . n 
A 1 301 PHE 301 1065 1065 PHE PHE A . n 
A 1 302 ASP 302 1066 1066 ASP ASP A . n 
A 1 303 ILE 303 1067 1067 ILE ILE A . n 
A 1 304 LEU 304 1068 1068 LEU LEU A . n 
A 1 305 VAL 305 1069 1069 VAL VAL A . n 
A 1 306 GLY 306 1070 1070 GLY GLY A . n 
A 1 307 GLN 307 1071 1071 GLN GLN A . n 
A 1 308 ILE 308 1072 1072 ILE ILE A . n 
A 1 309 ASP 309 1073 1073 ASP ASP A . n 
A 1 310 ASP 310 1074 1074 ASP ASP A . n 
A 1 311 ALA 311 1075 1075 ALA ALA A . n 
A 1 312 LEU 312 1076 1076 LEU LEU A . n 
A 1 313 LYS 313 1077 1077 LYS LYS A . n 
A 1 314 LEU 314 1078 1078 LEU LEU A . n 
A 1 315 ALA 315 1079 1079 ALA ALA A . n 
A 1 316 ASN 316 1080 1080 ASN ASN A . n 
A 1 317 GLU 317 1081 1081 GLU GLU A . n 
A 1 318 GLY 318 1082 1082 GLY GLY A . n 
A 1 319 LYS 319 1083 1083 LYS LYS A . n 
A 1 320 VAL 320 1084 1084 VAL VAL A . n 
A 1 321 LYS 321 1085 1085 LYS LYS A . n 
A 1 322 GLU 322 1086 1086 GLU GLU A . n 
A 1 323 ALA 323 1087 1087 ALA ALA A . n 
A 1 324 GLN 324 1088 1088 GLN GLN A . n 
A 1 325 ALA 325 1089 1089 ALA ALA A . n 
A 1 326 ALA 326 1090 1090 ALA ALA A . n 
A 1 327 ALA 327 1091 1091 ALA ALA A . n 
A 1 328 GLU 328 1092 1092 GLU GLU A . n 
A 1 329 GLN 329 1093 1093 GLN GLN A . n 
A 1 330 LEU 330 1094 1094 LEU LEU A . n 
A 1 331 LYS 331 1095 1095 LYS LYS A . n 
A 1 332 THR 332 1096 1096 THR THR A . n 
A 1 333 THR 333 1097 1097 THR THR A . n 
A 1 334 ARG 334 1098 1098 ARG ARG A . n 
A 1 335 ASN 335 1099 1099 ASN ASN A . n 
A 1 336 ALA 336 1100 1100 ALA ALA A . n 
A 1 337 TYR 337 1101 1101 TYR TYR A . n 
A 1 338 ILE 338 1102 1102 ILE ILE A . n 
A 1 339 GLN 339 1103 1103 GLN GLN A . n 
A 1 340 LYS 340 1104 1104 LYS LYS A . n 
A 1 341 TYR 341 1105 1105 TYR TYR A . n 
A 1 342 LEU 342 1106 1106 LEU LEU A . n 
A 1 343 ALA 343 900  900  ALA ALA A . n 
A 1 344 HIS 344 270  270  HIS HIS A . n 
A 1 345 LEU 345 271  271  LEU LEU A . n 
A 1 346 ALA 346 272  272  ALA ALA A . n 
A 1 347 ALA 347 273  273  ALA ALA A . n 
A 1 348 THR 348 274  274  THR THR A . n 
A 1 349 ARG 349 275  275  ARG ARG A . n 
A 1 350 LYS 350 276  276  LYS LYS A . n 
A 1 351 GLY 351 277  277  GLY GLY A . n 
A 1 352 VAL 352 278  278  VAL VAL A . n 
A 1 353 ARG 353 279  279  ARG ARG A . n 
A 1 354 THR 354 280  280  THR THR A . n 
A 1 355 LEU 355 281  281  LEU LEU A . n 
A 1 356 ALA 356 282  282  ALA ALA A . n 
A 1 357 VAL 357 283  283  VAL VAL A . n 
A 1 358 VAL 358 284  284  VAL VAL A . n 
A 1 359 LEU 359 285  285  LEU LEU A . n 
A 1 360 GLY 360 286  286  GLY GLY A . n 
A 1 361 THR 361 287  287  THR THR A . n 
A 1 362 PHE 362 288  288  PHE PHE A . n 
A 1 363 GLY 363 289  289  GLY GLY A . n 
A 1 364 ALA 364 290  290  ALA ALA A . n 
A 1 365 CYS 365 291  291  CYS CYS A . n 
A 1 366 TRP 366 292  292  TRP TRP A . n 
A 1 367 LEU 367 293  293  LEU LEU A . n 
A 1 368 PRO 368 294  294  PRO PRO A . n 
A 1 369 PHE 369 295  295  PHE PHE A . n 
A 1 370 ALA 370 296  296  ALA ALA A . n 
A 1 371 ILE 371 297  297  ILE ILE A . n 
A 1 372 TYR 372 298  298  TYR TYR A . n 
A 1 373 CYS 373 299  299  CYS CYS A . n 
A 1 374 VAL 374 300  300  VAL VAL A . n 
A 1 375 VAL 375 301  301  VAL VAL A . n 
A 1 376 GLY 376 302  302  GLY GLY A . n 
A 1 377 SER 377 303  303  SER SER A . n 
A 1 378 HIS 378 304  304  HIS HIS A . n 
A 1 379 GLU 379 305  305  GLU GLU A . n 
A 1 380 ASP 380 306  306  ASP ASP A . n 
A 1 381 PRO 381 307  307  PRO PRO A . n 
A 1 382 ALA 382 308  308  ALA ALA A . n 
A 1 383 VAL 383 309  309  VAL VAL A . n 
A 1 384 TYR 384 310  310  TYR TYR A . n 
A 1 385 THR 385 311  311  THR THR A . n 
A 1 386 TYR 386 312  312  TYR TYR A . n 
A 1 387 ALA 387 313  313  ALA ALA A . n 
A 1 388 THR 388 314  314  THR THR A . n 
A 1 389 LEU 389 315  315  LEU LEU A . n 
A 1 390 LEU 390 316  316  LEU LEU A . n 
A 1 391 PRO 391 317  317  PRO PRO A . n 
A 1 392 ALA 392 318  318  ALA ALA A . n 
A 1 393 THR 393 319  319  THR THR A . n 
A 1 394 LEU 394 320  320  LEU LEU A . n 
A 1 395 ASN 395 321  321  ASN ASN A . n 
A 1 396 SER 396 322  322  SER SER A . n 
A 1 397 MET 397 323  323  MET MET A . n 
A 1 398 ILE 398 324  324  ILE ILE A . n 
A 1 399 ASN 399 325  325  ASN ASN A . n 
A 1 400 PRO 400 326  326  PRO PRO A . n 
A 1 401 ILE 401 327  327  ILE ILE A . n 
A 1 402 ILE 402 328  328  ILE ILE A . n 
A 1 403 TYR 403 329  329  TYR TYR A . n 
A 1 404 ALA 404 330  330  ALA ALA A . n 
A 1 405 PHE 405 331  331  PHE PHE A . n 
A 1 406 ARG 406 332  332  ARG ARG A . n 
A 1 407 ASN 407 333  333  ASN ASN A . n 
A 1 408 GLN 408 334  334  GLN GLN A . n 
A 1 409 GLU 409 335  335  GLU GLU A . n 
A 1 410 ILE 410 336  336  ILE ILE A . n 
A 1 411 GLN 411 337  337  GLN GLN A . n 
A 1 412 ARG 412 338  338  ARG ARG A . n 
A 1 413 ALA 413 339  339  ALA ALA A . n 
A 1 414 LEU 414 340  340  LEU LEU A . n 
A 1 415 TRP 415 341  341  TRP TRP A . n 
A 1 416 LEU 416 342  342  LEU LEU A . n 
A 1 417 LEU 417 343  343  LEU LEU A . n 
A 1 418 LEU 418 344  344  LEU LEU A . n 
A 1 419 ASP 419 345  345  ASP ASP A . n 
A 1 420 GLY 420 346  346  GLY GLY A . n 
A 1 421 CYS 421 347  347  CYS CYS A . n 
A 1 422 PHE 422 348  ?    ?   ?   A . n 
A 1 423 GLN 423 349  ?    ?   ?   A . n 
A 1 424 SER 424 350  ?    ?   ?   A . n 
A 1 425 LYS 425 351  ?    ?   ?   A . n 
A 1 426 VAL 426 352  ?    ?   ?   A . n 
A 1 427 PRO 427 353  ?    ?   ?   A . n 
A 1 428 PHE 428 354  ?    ?   ?   A . n 
A 1 429 ARG 429 355  ?    ?   ?   A . n 
A 1 430 SER 430 356  ?    ?   ?   A . n 
A 1 431 ARG 431 357  ?    ?   ?   A . n 
A 1 432 SER 432 358  ?    ?   ?   A . n 
A 1 433 PRO 433 359  ?    ?   ?   A . n 
A 1 434 SER 434 360  ?    ?   ?   A . n 
A 1 435 GLU 435 361  ?    ?   ?   A . n 
A 1 436 VAL 436 362  ?    ?   ?   A . n 
A 1 437 GLU 437 363  ?    ?   ?   A . n 
A 1 438 PHE 438 364  ?    ?   ?   A . n 
A 1 439 LEU 439 365  ?    ?   ?   A . n 
A 1 440 GLU 440 366  ?    ?   ?   A . n 
A 1 441 VAL 441 367  ?    ?   ?   A . n 
A 1 442 LEU 442 368  ?    ?   ?   A . n 
A 1 443 PHE 443 369  ?    ?   ?   A . n 
A 1 444 GLN 444 370  ?    ?   ?   A . n 
A 1 445 GLY 445 371  ?    ?   ?   A . n 
A 1 446 PRO 446 372  ?    ?   ?   A . n 
A 1 447 HIS 447 373  ?    ?   ?   A . n 
A 1 448 HIS 448 374  ?    ?   ?   A . n 
A 1 449 HIS 449 375  ?    ?   ?   A . n 
A 1 450 HIS 450 376  ?    ?   ?   A . n 
A 1 451 HIS 451 377  ?    ?   ?   A . n 
A 1 452 HIS 452 378  ?    ?   ?   A . n 
A 1 453 HIS 453 379  ?    ?   ?   A . n 
A 1 454 HIS 454 380  ?    ?   ?   A . n 
A 1 455 HIS 455 381  ?    ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X7T 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X7T 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          X7T 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     1201 
_pdbx_nonpoly_scheme.auth_seq_num    701 
_pdbx_nonpoly_scheme.pdb_mon_id      X7T 
_pdbx_nonpoly_scheme.auth_mon_id     XY9 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A LEU 69   ? CG  ? A LEU 49  CG  
2   1 Y 1 A LEU 69   ? CD1 ? A LEU 49  CD1 
3   1 Y 1 A LEU 69   ? CD2 ? A LEU 49  CD2 
4   1 Y 1 A GLN 132  ? CG  ? A GLN 112 CG  
5   1 Y 1 A GLN 132  ? CD  ? A GLN 112 CD  
6   1 Y 1 A GLN 132  ? OE1 ? A GLN 112 OE1 
7   1 Y 1 A GLN 132  ? NE2 ? A GLN 112 NE2 
8   1 Y 1 A LEU 134  ? CG  ? A LEU 114 CG  
9   1 Y 1 A LEU 134  ? CD1 ? A LEU 114 CD1 
10  1 Y 1 A LEU 134  ? CD2 ? A LEU 114 CD2 
11  1 Y 1 A VAL 135  ? CG1 ? A VAL 115 CG1 
12  1 Y 1 A VAL 135  ? CG2 ? A VAL 115 CG2 
13  1 Y 1 A LEU 168  ? CG  ? A LEU 148 CG  
14  1 Y 1 A LEU 168  ? CD1 ? A LEU 148 CD1 
15  1 Y 1 A LEU 168  ? CD2 ? A LEU 148 CD2 
16  1 Y 1 A TYR 177  ? CG  ? A TYR 157 CG  
17  1 Y 1 A TYR 177  ? CD1 ? A TYR 157 CD1 
18  1 Y 1 A TYR 177  ? CD2 ? A TYR 157 CD2 
19  1 Y 1 A TYR 177  ? CE1 ? A TYR 157 CE1 
20  1 Y 1 A TYR 177  ? CE2 ? A TYR 157 CE2 
21  1 Y 1 A TYR 177  ? CZ  ? A TYR 157 CZ  
22  1 Y 1 A TYR 177  ? OH  ? A TYR 157 OH  
23  1 Y 1 A GLU 212  ? CG  ? A GLU 192 CG  
24  1 Y 1 A GLU 212  ? CD  ? A GLU 192 CD  
25  1 Y 1 A GLU 212  ? OE1 ? A GLU 192 OE1 
26  1 Y 1 A GLU 212  ? OE2 ? A GLU 192 OE2 
27  1 Y 1 A GLU 1004 ? CG  ? A GLU 240 CG  
28  1 Y 1 A GLU 1004 ? CD  ? A GLU 240 CD  
29  1 Y 1 A GLU 1004 ? OE1 ? A GLU 240 OE1 
30  1 Y 1 A GLU 1004 ? OE2 ? A GLU 240 OE2 
31  1 Y 1 A LYS 1015 ? CG  ? A LYS 251 CG  
32  1 Y 1 A LYS 1015 ? CD  ? A LYS 251 CD  
33  1 Y 1 A LYS 1015 ? CE  ? A LYS 251 CE  
34  1 Y 1 A LYS 1015 ? NZ  ? A LYS 251 NZ  
35  1 Y 1 A GLN 1025 ? CG  ? A GLN 261 CG  
36  1 Y 1 A GLN 1025 ? CD  ? A GLN 261 CD  
37  1 Y 1 A GLN 1025 ? OE1 ? A GLN 261 OE1 
38  1 Y 1 A GLN 1025 ? NE2 ? A GLN 261 NE2 
39  1 Y 1 A LYS 1027 ? CG  ? A LYS 263 CG  
40  1 Y 1 A LYS 1027 ? CD  ? A LYS 263 CD  
41  1 Y 1 A LYS 1027 ? CE  ? A LYS 263 CE  
42  1 Y 1 A LYS 1027 ? NZ  ? A LYS 263 NZ  
43  1 Y 1 A GLN 1041 ? CG  ? A GLN 277 CG  
44  1 Y 1 A GLN 1041 ? CD  ? A GLN 277 CD  
45  1 Y 1 A GLN 1041 ? OE1 ? A GLN 277 OE1 
46  1 Y 1 A GLN 1041 ? NE2 ? A GLN 277 NE2 
47  1 Y 1 A LYS 1042 ? CG  ? A LYS 278 CG  
48  1 Y 1 A LYS 1042 ? CD  ? A LYS 278 CD  
49  1 Y 1 A LYS 1042 ? CE  ? A LYS 278 CE  
50  1 Y 1 A LYS 1042 ? NZ  ? A LYS 278 NZ  
51  1 Y 1 A HIS 1063 ? CG  ? A HIS 299 CG  
52  1 Y 1 A HIS 1063 ? ND1 ? A HIS 299 ND1 
53  1 Y 1 A HIS 1063 ? CD2 ? A HIS 299 CD2 
54  1 Y 1 A HIS 1063 ? CE1 ? A HIS 299 CE1 
55  1 Y 1 A HIS 1063 ? NE2 ? A HIS 299 NE2 
56  1 Y 1 A PHE 1065 ? CG  ? A PHE 301 CG  
57  1 Y 1 A PHE 1065 ? CD1 ? A PHE 301 CD1 
58  1 Y 1 A PHE 1065 ? CD2 ? A PHE 301 CD2 
59  1 Y 1 A PHE 1065 ? CE1 ? A PHE 301 CE1 
60  1 Y 1 A PHE 1065 ? CE2 ? A PHE 301 CE2 
61  1 Y 1 A PHE 1065 ? CZ  ? A PHE 301 CZ  
62  1 Y 1 A LYS 1085 ? CG  ? A LYS 321 CG  
63  1 Y 1 A LYS 1085 ? CD  ? A LYS 321 CD  
64  1 Y 1 A LYS 1085 ? CE  ? A LYS 321 CE  
65  1 Y 1 A LYS 1085 ? NZ  ? A LYS 321 NZ  
66  1 Y 1 A LYS 1095 ? CG  ? A LYS 331 CG  
67  1 Y 1 A LYS 1095 ? CD  ? A LYS 331 CD  
68  1 Y 1 A LYS 1095 ? CE  ? A LYS 331 CE  
69  1 Y 1 A LYS 1095 ? NZ  ? A LYS 331 NZ  
70  1 Y 1 A TYR 1101 ? CG  ? A TYR 337 CG  
71  1 Y 1 A TYR 1101 ? CD1 ? A TYR 337 CD1 
72  1 Y 1 A TYR 1101 ? CD2 ? A TYR 337 CD2 
73  1 Y 1 A TYR 1101 ? CE1 ? A TYR 337 CE1 
74  1 Y 1 A TYR 1101 ? CE2 ? A TYR 337 CE2 
75  1 Y 1 A TYR 1101 ? CZ  ? A TYR 337 CZ  
76  1 Y 1 A TYR 1101 ? OH  ? A TYR 337 OH  
77  1 Y 1 A GLN 1103 ? CG  ? A GLN 339 CG  
78  1 Y 1 A GLN 1103 ? CD  ? A GLN 339 CD  
79  1 Y 1 A GLN 1103 ? OE1 ? A GLN 339 OE1 
80  1 Y 1 A GLN 1103 ? NE2 ? A GLN 339 NE2 
81  1 Y 1 A LYS 1104 ? CG  ? A LYS 340 CG  
82  1 Y 1 A LYS 1104 ? CD  ? A LYS 340 CD  
83  1 Y 1 A LYS 1104 ? CE  ? A LYS 340 CE  
84  1 Y 1 A LYS 1104 ? NZ  ? A LYS 340 NZ  
85  1 Y 1 A ARG 275  ? CG  ? A ARG 349 CG  
86  1 Y 1 A ARG 275  ? CD  ? A ARG 349 CD  
87  1 Y 1 A ARG 275  ? NE  ? A ARG 349 NE  
88  1 Y 1 A ARG 275  ? CZ  ? A ARG 349 CZ  
89  1 Y 1 A ARG 275  ? NH1 ? A ARG 349 NH1 
90  1 Y 1 A ARG 275  ? NH2 ? A ARG 349 NH2 
91  1 Y 1 A LYS 276  ? CG  ? A LYS 350 CG  
92  1 Y 1 A LYS 276  ? CD  ? A LYS 350 CD  
93  1 Y 1 A LYS 276  ? CE  ? A LYS 350 CE  
94  1 Y 1 A LYS 276  ? NZ  ? A LYS 350 NZ  
95  1 Y 1 A TYR 312  ? CG  ? A TYR 386 CG  
96  1 Y 1 A TYR 312  ? CD1 ? A TYR 386 CD1 
97  1 Y 1 A TYR 312  ? CD2 ? A TYR 386 CD2 
98  1 Y 1 A TYR 312  ? CE1 ? A TYR 386 CE1 
99  1 Y 1 A TYR 312  ? CE2 ? A TYR 386 CE2 
100 1 Y 1 A TYR 312  ? CZ  ? A TYR 386 CZ  
101 1 Y 1 A TYR 312  ? OH  ? A TYR 386 OH  
102 1 Y 1 A ARG 338  ? CG  ? A ARG 412 CG  
103 1 Y 1 A ARG 338  ? CD  ? A ARG 412 CD  
104 1 Y 1 A ARG 338  ? NE  ? A ARG 412 NE  
105 1 Y 1 A ARG 338  ? CZ  ? A ARG 412 CZ  
106 1 Y 1 A ARG 338  ? NH1 ? A ARG 412 NH1 
107 1 Y 1 A ARG 338  ? NH2 ? A ARG 412 NH2 
108 1 Y 1 A LEU 344  ? CG  ? A LEU 418 CG  
109 1 Y 1 A LEU 344  ? CD1 ? A LEU 418 CD1 
110 1 Y 1 A LEU 344  ? CD2 ? A LEU 418 CD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? '(1.20.1_4487: ???)' 1 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .                    3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8T1W 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     63.731 
_cell.length_a_esd                 ? 
_cell.length_b                     63.731 
_cell.length_b_esd                 ? 
_cell.length_c                     250.932 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8T1W 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8T1W 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.89 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.43 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'LIPIDIC CUBIC PHASE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'NaCH3COO, PEG 400, NaCl, PPG P40' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     123 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-11-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0332 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 23-ID-B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0332 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   23-ID-B 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8T1W 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.49 
_reflns.d_resolution_low                               50.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     7983 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          28.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.00 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    3.50 
_reflns_shell.d_res_low                                     3.56 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             406 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.403 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.89 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8T1W 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.49 
_refine.ls_d_res_low                             46.07 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     7814 
_refine.ls_number_reflns_R_free                  413 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.48 
_refine.ls_percent_reflns_R_free                 5.29 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2929 
_refine.ls_R_factor_R_free                       0.3219 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2913 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 43.43 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.68 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2617 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               2651 
_refine_hist.d_res_high                       3.49 
_refine_hist.d_res_low                        46.07 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.004  ? 2714 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.634  ? 3732 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 11.643 ? 894  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.034  ? 467  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.005  ? 463  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.49 3.56  . . 132 2377 95.00 . . . . 0.3659 . . . . . . . . . . . 0.4236 
'X-RAY DIFFRACTION' 3.56 5.04  . . 143 2446 98.00 . . . . 0.3175 . . . . . . . . . . . 0.3713 
'X-RAY DIFFRACTION' 5.04 46.07 . . 138 2578 96.00 . . . . 0.2686 . . . . . . . . . . . 0.2842 
# 
_struct.entry_id                     8T1W 
_struct.title                        'Crystal structure of orphan G protein-coupled receptor 6 with bound CVN424' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8T1W 
_struct_keywords.text            'Orphan GPCR, GPR6, BRIL, CVN424, inverse agonist, LCP, synchrotron, APS, membrane protein' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP GPR6_HUMAN P46095 ? 1 
;GGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLIL
HFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGW
NCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHA
;
48  
2 UNP C562_ECOLX P0ABE7 ? 1 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKYR
;
23  
3 UNP GPR6_HUMAN P46095 ? 1 
;HLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQ
SKVPFRSRSPSEV
;
270 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8T1W A 28  ? 236 ? P46095 48  ? 256 ? 48   256  
2 2 8T1W A 237 ? 342 ? P0ABE7 23  ? 128 ? 1001 1106 
3 3 8T1W A 344 ? 436 ? P46095 270 ? 362 ? 270  362  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8T1W MET A 1   ? UNP P46095 ?   ?   'initiating methionine' 21   1  
1 8T1W LYS A 2   ? UNP P46095 ?   ?   'expression tag'        22   2  
1 8T1W THR A 3   ? UNP P46095 ?   ?   'expression tag'        23   3  
1 8T1W ILE A 4   ? UNP P46095 ?   ?   'expression tag'        24   4  
1 8T1W ILE A 5   ? UNP P46095 ?   ?   'expression tag'        25   5  
1 8T1W ALA A 6   ? UNP P46095 ?   ?   'expression tag'        26   6  
1 8T1W LEU A 7   ? UNP P46095 ?   ?   'expression tag'        27   7  
1 8T1W SER A 8   ? UNP P46095 ?   ?   'expression tag'        28   8  
1 8T1W TYR A 9   ? UNP P46095 ?   ?   'expression tag'        29   9  
1 8T1W ILE A 10  ? UNP P46095 ?   ?   'expression tag'        30   10 
1 8T1W PHE A 11  ? UNP P46095 ?   ?   'expression tag'        31   11 
1 8T1W CYS A 12  ? UNP P46095 ?   ?   'expression tag'        32   12 
1 8T1W LEU A 13  ? UNP P46095 ?   ?   'expression tag'        33   13 
1 8T1W VAL A 14  ? UNP P46095 ?   ?   'expression tag'        34   14 
1 8T1W PHE A 15  ? UNP P46095 ?   ?   'expression tag'        35   15 
1 8T1W ALA A 16  ? UNP P46095 ?   ?   'expression tag'        36   16 
1 8T1W ASP A 17  ? UNP P46095 ?   ?   'expression tag'        37   17 
1 8T1W TYR A 18  ? UNP P46095 ?   ?   'expression tag'        38   18 
1 8T1W LYS A 19  ? UNP P46095 ?   ?   'expression tag'        39   19 
1 8T1W ASP A 20  ? UNP P46095 ?   ?   'expression tag'        40   20 
1 8T1W ASP A 21  ? UNP P46095 ?   ?   'expression tag'        41   21 
1 8T1W ASP A 22  ? UNP P46095 ?   ?   'expression tag'        42   22 
1 8T1W ASP A 23  ? UNP P46095 ?   ?   'expression tag'        43   23 
1 8T1W ALA A 24  ? UNP P46095 ?   ?   'expression tag'        44   24 
1 8T1W GLY A 25  ? UNP P46095 ?   ?   'expression tag'        45   25 
1 8T1W ARG A 26  ? UNP P46095 ?   ?   'expression tag'        46   26 
1 8T1W ALA A 27  ? UNP P46095 ?   ?   'expression tag'        47   27 
1 8T1W LEU A 103 ? UNP P46095 CYS 123 'engineered mutation'   123  28 
1 8T1W PRO A 153 ? UNP P46095 ALA 173 'engineered mutation'   173  29 
2 8T1W TRP A 243 ? UNP P0ABE7 MET 29  'engineered mutation'   1007 30 
2 8T1W ILE A 338 ? UNP P0ABE7 HIS 124 'engineered mutation'   1102 31 
2 8T1W LEU A 342 ? UNP P0ABE7 ARG 128 'engineered mutation'   1106 32 
2 8T1W ALA A 343 ? UNP P0ABE7 ?   ?   linker                  900  33 
3 8T1W ARG A 353 ? UNP P46095 GLY 279 'engineered mutation'   279  34 
3 8T1W CYS A 365 ? UNP P46095 SER 291 'engineered mutation'   291  35 
3 8T1W LEU A 394 ? UNP P46095 TYR 320 'engineered mutation'   320  36 
3 8T1W ASP A 419 ? UNP P46095 CYS 345 'engineered mutation'   345  37 
3 8T1W GLU A 437 ? UNP P46095 ?   ?   'expression tag'        363  38 
3 8T1W PHE A 438 ? UNP P46095 ?   ?   'expression tag'        364  39 
3 8T1W LEU A 439 ? UNP P46095 ?   ?   'expression tag'        365  40 
3 8T1W GLU A 440 ? UNP P46095 ?   ?   'expression tag'        366  41 
3 8T1W VAL A 441 ? UNP P46095 ?   ?   'expression tag'        367  42 
3 8T1W LEU A 442 ? UNP P46095 ?   ?   'expression tag'        368  43 
3 8T1W PHE A 443 ? UNP P46095 ?   ?   'expression tag'        369  44 
3 8T1W GLN A 444 ? UNP P46095 ?   ?   'expression tag'        370  45 
3 8T1W GLY A 445 ? UNP P46095 ?   ?   'expression tag'        371  46 
3 8T1W PRO A 446 ? UNP P46095 ?   ?   'expression tag'        372  47 
3 8T1W HIS A 447 ? UNP P46095 ?   ?   'expression tag'        373  48 
3 8T1W HIS A 448 ? UNP P46095 ?   ?   'expression tag'        374  49 
3 8T1W HIS A 449 ? UNP P46095 ?   ?   'expression tag'        375  50 
3 8T1W HIS A 450 ? UNP P46095 ?   ?   'expression tag'        376  51 
3 8T1W HIS A 451 ? UNP P46095 ?   ?   'expression tag'        377  52 
3 8T1W HIS A 452 ? UNP P46095 ?   ?   'expression tag'        378  53 
3 8T1W HIS A 453 ? UNP P46095 ?   ?   'expression tag'        379  54 
3 8T1W HIS A 454 ? UNP P46095 ?   ?   'expression tag'        380  55 
3 8T1W HIS A 455 ? UNP P46095 ?   ?   'expression tag'        381  56 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 51  ? THR A 80  ? ALA A 71   THR A 100  1 ? 30 
HELX_P HELX_P2  AA2 PRO A 81  ? ARG A 84  ? PRO A 101  ARG A 104  5 ? 4  
HELX_P HELX_P3  AA3 THR A 85  ? TYR A 113 ? THR A 105  TYR A 133  1 ? 29 
HELX_P HELX_P4  AA4 SER A 117 ? ASN A 152 ? SER A 137  ASN A 172  1 ? 36 
HELX_P HELX_P5  AA5 TYR A 157 ? GLY A 186 ? TYR A 177  GLY A 206  1 ? 30 
HELX_P HELX_P6  AA6 ALA A 203 ? LYS A 255 ? ALA A 223  LYS A 1019 1 ? 53 
HELX_P HELX_P7  AA7 ASN A 258 ? THR A 280 ? ASN A 1022 THR A 1044 1 ? 23 
HELX_P HELX_P8  AA8 PHE A 301 ? GLU A 317 ? PHE A 1065 GLU A 1081 1 ? 17 
HELX_P HELX_P9  AA9 LYS A 319 ? GLY A 376 ? LYS A 1083 GLY A 302  1 ? 58 
HELX_P HELX_P10 AB1 PRO A 381 ? ASN A 407 ? PRO A 307  ASN A 333  1 ? 27 
HELX_P HELX_P11 AB2 ASN A 407 ? CYS A 421 ? ASN A 333  CYS A 347  1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            189 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            196 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             209 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             216 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.030 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       189 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      196 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        209 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       216 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          ARG 
_struct_mon_prot_cis.label_seq_id           200 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           ARG 
_struct_mon_prot_cis.auth_seq_id            220 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    201 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     221 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.09 
# 
_pdbx_entry_details.entry_id                   8T1W 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 172 ? ? -159.17 79.19 
2 1 LEU A 210 ? ? -94.60  33.95 
3 1 PRO A 221 ? ? -93.31  46.18 
4 1 HIS A 304 ? ? 70.08   -4.33 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 21   ? A MET 1   
2  1 Y 1 A LYS 22   ? A LYS 2   
3  1 Y 1 A THR 23   ? A THR 3   
4  1 Y 1 A ILE 24   ? A ILE 4   
5  1 Y 1 A ILE 25   ? A ILE 5   
6  1 Y 1 A ALA 26   ? A ALA 6   
7  1 Y 1 A LEU 27   ? A LEU 7   
8  1 Y 1 A SER 28   ? A SER 8   
9  1 Y 1 A TYR 29   ? A TYR 9   
10 1 Y 1 A ILE 30   ? A ILE 10  
11 1 Y 1 A PHE 31   ? A PHE 11  
12 1 Y 1 A CYS 32   ? A CYS 12  
13 1 Y 1 A LEU 33   ? A LEU 13  
14 1 Y 1 A VAL 34   ? A VAL 14  
15 1 Y 1 A PHE 35   ? A PHE 15  
16 1 Y 1 A ALA 36   ? A ALA 16  
17 1 Y 1 A ASP 37   ? A ASP 17  
18 1 Y 1 A TYR 38   ? A TYR 18  
19 1 Y 1 A LYS 39   ? A LYS 19  
20 1 Y 1 A ASP 40   ? A ASP 20  
21 1 Y 1 A ASP 41   ? A ASP 21  
22 1 Y 1 A ASP 42   ? A ASP 22  
23 1 Y 1 A ASP 43   ? A ASP 23  
24 1 Y 1 A ALA 44   ? A ALA 24  
25 1 Y 1 A GLY 45   ? A GLY 25  
26 1 Y 1 A ARG 46   ? A ARG 26  
27 1 Y 1 A ALA 47   ? A ALA 27  
28 1 Y 1 A GLY 48   ? A GLY 28  
29 1 Y 1 A GLY 49   ? A GLY 29  
30 1 Y 1 A ALA 50   ? A ALA 30  
31 1 Y 1 A ASN 51   ? A ASN 31  
32 1 Y 1 A GLY 52   ? A GLY 32  
33 1 Y 1 A SER 53   ? A SER 33  
34 1 Y 1 A LEU 54   ? A LEU 34  
35 1 Y 1 A GLU 55   ? A GLU 35  
36 1 Y 1 A LEU 56   ? A LEU 36  
37 1 Y 1 A SER 57   ? A SER 37  
38 1 Y 1 A SER 58   ? A SER 38  
39 1 Y 1 A GLN 59   ? A GLN 39  
40 1 Y 1 A LEU 60   ? A LEU 40  
41 1 Y 1 A SER 61   ? A SER 41  
42 1 Y 1 A ALA 62   ? A ALA 42  
43 1 Y 1 A GLY 63   ? A GLY 43  
44 1 Y 1 A PRO 64   ? A PRO 44  
45 1 Y 1 A PRO 65   ? A PRO 45  
46 1 Y 1 A GLY 66   ? A GLY 46  
47 1 Y 1 A LEU 67   ? A LEU 47  
48 1 Y 1 A LEU 68   ? A LEU 48  
49 1 Y 1 A LYS 1047 ? A LYS 283 
50 1 Y 1 A LEU 1048 ? A LEU 284 
51 1 Y 1 A GLU 1049 ? A GLU 285 
52 1 Y 1 A ASP 1050 ? A ASP 286 
53 1 Y 1 A LYS 1051 ? A LYS 287 
54 1 Y 1 A SER 1052 ? A SER 288 
55 1 Y 1 A PRO 1053 ? A PRO 289 
56 1 Y 1 A ASP 1054 ? A ASP 290 
57 1 Y 1 A SER 1055 ? A SER 291 
58 1 Y 1 A PRO 1056 ? A PRO 292 
59 1 Y 1 A GLU 1057 ? A GLU 293 
60 1 Y 1 A MET 1058 ? A MET 294 
61 1 Y 1 A LYS 1059 ? A LYS 295 
62 1 Y 1 A ASP 1060 ? A ASP 296 
63 1 Y 1 A PHE 1061 ? A PHE 297 
64 1 Y 1 A ARG 1062 ? A ARG 298 
65 1 Y 1 A PHE 348  ? A PHE 422 
66 1 Y 1 A GLN 349  ? A GLN 423 
67 1 Y 1 A SER 350  ? A SER 424 
68 1 Y 1 A LYS 351  ? A LYS 425 
69 1 Y 1 A VAL 352  ? A VAL 426 
70 1 Y 1 A PRO 353  ? A PRO 427 
71 1 Y 1 A PHE 354  ? A PHE 428 
72 1 Y 1 A ARG 355  ? A ARG 429 
73 1 Y 1 A SER 356  ? A SER 430 
74 1 Y 1 A ARG 357  ? A ARG 431 
75 1 Y 1 A SER 358  ? A SER 432 
76 1 Y 1 A PRO 359  ? A PRO 433 
77 1 Y 1 A SER 360  ? A SER 434 
78 1 Y 1 A GLU 361  ? A GLU 435 
79 1 Y 1 A VAL 362  ? A VAL 436 
80 1 Y 1 A GLU 363  ? A GLU 437 
81 1 Y 1 A PHE 364  ? A PHE 438 
82 1 Y 1 A LEU 365  ? A LEU 439 
83 1 Y 1 A GLU 366  ? A GLU 440 
84 1 Y 1 A VAL 367  ? A VAL 441 
85 1 Y 1 A LEU 368  ? A LEU 442 
86 1 Y 1 A PHE 369  ? A PHE 443 
87 1 Y 1 A GLN 370  ? A GLN 444 
88 1 Y 1 A GLY 371  ? A GLY 445 
89 1 Y 1 A PRO 372  ? A PRO 446 
90 1 Y 1 A HIS 373  ? A HIS 447 
91 1 Y 1 A HIS 374  ? A HIS 448 
92 1 Y 1 A HIS 375  ? A HIS 449 
93 1 Y 1 A HIS 376  ? A HIS 450 
94 1 Y 1 A HIS 377  ? A HIS 451 
95 1 Y 1 A HIS 378  ? A HIS 452 
96 1 Y 1 A HIS 379  ? A HIS 453 
97 1 Y 1 A HIS 380  ? A HIS 454 
98 1 Y 1 A HIS 381  ? A HIS 455 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
X7T C2   C Y N 388 
X7T C5   C Y N 389 
X7T C1   C Y N 390 
X7T C3   C Y N 391 
X7T C4   C Y N 392 
X7T O2   O N N 393 
X7T O3   O N N 394 
X7T O1   O N N 395 
X7T C10  C N N 396 
X7T C11  C N N 397 
X7T C12  C Y N 398 
X7T C13  C Y N 399 
X7T C14  C N N 400 
X7T C15  C N N 401 
X7T C16  C N N 402 
X7T C17  C Y N 403 
X7T C18  C Y N 404 
X7T C19  C N R 405 
X7T C20  C N N 406 
X7T C21  C N N 407 
X7T C22  C N N 408 
X7T C23  C N N 409 
X7T C24  C N N 410 
X7T C6   C Y N 411 
X7T C7   C N N 412 
X7T C8   C N N 413 
X7T C9   C N N 414 
X7T F1   F N N 415 
X7T F2   F N N 416 
X7T N1   N N N 417 
X7T N2   N Y N 418 
X7T N3   N N N 419 
X7T N4   N Y N 420 
X7T N5   N N N 421 
X7T H1   H N N 422 
X7T H2   H N N 423 
X7T H3   H N N 424 
X7T H4   H N N 425 
X7T H5   H N N 426 
X7T H6   H N N 427 
X7T H7   H N N 428 
X7T H8   H N N 429 
X7T H9   H N N 430 
X7T H10  H N N 431 
X7T H11  H N N 432 
X7T H12  H N N 433 
X7T H13  H N N 434 
X7T H14  H N N 435 
X7T H15  H N N 436 
X7T H16  H N N 437 
X7T H17  H N N 438 
X7T H18  H N N 439 
X7T H19  H N N 440 
X7T H20  H N N 441 
X7T H21  H N N 442 
X7T H22  H N N 443 
X7T H23  H N N 444 
X7T H24  H N N 445 
X7T H25  H N N 446 
X7T H26  H N N 447 
X7T H27  H N N 448 
X7T H28  H N N 449 
X7T H29  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
X7T C21 O2   sing N N 374 
X7T C21 C22  sing N N 375 
X7T O2  C20  sing N N 376 
X7T C22 C19  sing N N 377 
X7T C20 C19  sing N N 378 
X7T C19 N5   sing N N 379 
X7T C2  C3   doub Y N 380 
X7T C2  C1   sing Y N 381 
X7T C3  C4   sing Y N 382 
X7T F1  C1   sing N N 383 
X7T C1  C6   doub Y N 384 
X7T N5  C18  sing N N 385 
X7T C4  O1   sing N N 386 
X7T C4  C5   doub Y N 387 
X7T O1  C7   sing N N 388 
X7T C8  C7   sing N N 389 
X7T C8  C9   sing N N 390 
X7T C6  C5   sing Y N 391 
X7T C5  F2   sing N N 392 
X7T C7  C11  sing N N 393 
X7T C9  N1   sing N N 394 
X7T C11 C10  sing N N 395 
X7T C18 N4   doub Y N 396 
X7T C18 C12  sing Y N 397 
X7T N1  C12  sing N N 398 
X7T N1  C10  sing N N 399 
X7T N4  C17  sing Y N 400 
X7T C12 N2   doub Y N 401 
X7T C17 C16  sing N N 402 
X7T C17 C13  doub Y N 403 
X7T N2  C13  sing Y N 404 
X7T C16 N3   sing N N 405 
X7T C13 C14  sing N N 406 
X7T C14 C15  sing N N 407 
X7T N3  C15  sing N N 408 
X7T N3  C23  sing N N 409 
X7T O3  C23  doub N N 410 
X7T C23 C24  sing N N 411 
X7T C2  H1   sing N N 412 
X7T C3  H2   sing N N 413 
X7T C10 H3   sing N N 414 
X7T C10 H4   sing N N 415 
X7T C11 H5   sing N N 416 
X7T C11 H6   sing N N 417 
X7T C14 H7   sing N N 418 
X7T C14 H8   sing N N 419 
X7T C15 H9   sing N N 420 
X7T C15 H10  sing N N 421 
X7T C16 H11  sing N N 422 
X7T C16 H12  sing N N 423 
X7T C19 H13  sing N N 424 
X7T C20 H14  sing N N 425 
X7T C20 H15  sing N N 426 
X7T C21 H16  sing N N 427 
X7T C21 H17  sing N N 428 
X7T C22 H18  sing N N 429 
X7T C22 H19  sing N N 430 
X7T C24 H20  sing N N 431 
X7T C24 H21  sing N N 432 
X7T C24 H22  sing N N 433 
X7T C6  H23  sing N N 434 
X7T C7  H24  sing N N 435 
X7T C8  H25  sing N N 436 
X7T C8  H26  sing N N 437 
X7T C9  H27  sing N N 438 
X7T C9  H28  sing N N 439 
X7T N5  H29  sing N N 440 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R35 GM127086' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'GPR6 IAG3h' 
# 
_atom_sites.entry_id                    8T1W 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.015691 
_atom_sites.fract_transf_matrix[1][2]   0.009059 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018118 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003985 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
F 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LEU A 1 49  ? -0.877  24.142  11.455  1.00 216.80 ? 69   LEU A N   1 
ATOM   2    C CA  . LEU A 1 49  ? -0.748  23.001  10.555  1.00 229.68 ? 69   LEU A CA  1 
ATOM   3    C C   . LEU A 1 49  ? -0.916  21.691  11.325  1.00 241.28 ? 69   LEU A C   1 
ATOM   4    O O   . LEU A 1 49  ? -1.902  20.987  11.122  1.00 247.33 ? 69   LEU A O   1 
ATOM   5    C CB  . LEU A 1 49  ? 0.599   23.035  9.830   1.00 223.59 ? 69   LEU A CB  1 
ATOM   6    N N   . PRO A 1 50  ? 0.023   21.371  12.223  1.00 256.15 ? 70   PRO A N   1 
ATOM   7    C CA  . PRO A 1 50  ? -0.132  20.155  13.042  1.00 261.06 ? 70   PRO A CA  1 
ATOM   8    C C   . PRO A 1 50  ? -1.345  20.202  13.959  1.00 250.37 ? 70   PRO A C   1 
ATOM   9    O O   . PRO A 1 50  ? -1.688  19.178  14.564  1.00 243.15 ? 70   PRO A O   1 
ATOM   10   C CB  . PRO A 1 50  ? 1.178   20.098  13.841  1.00 246.57 ? 70   PRO A CB  1 
ATOM   11   C CG  . PRO A 1 50  ? 1.625   21.510  13.919  1.00 260.25 ? 70   PRO A CG  1 
ATOM   12   C CD  . PRO A 1 50  ? 1.226   22.131  12.607  1.00 264.27 ? 70   PRO A CD  1 
ATOM   13   N N   . ALA A 1 51  ? -1.985  21.360  14.085  1.00 249.27 ? 71   ALA A N   1 
ATOM   14   C CA  . ALA A 1 51  ? -3.183  21.504  14.901  1.00 231.55 ? 71   ALA A CA  1 
ATOM   15   C C   . ALA A 1 51  ? -4.358  20.736  14.295  1.00 242.21 ? 71   ALA A C   1 
ATOM   16   O O   . ALA A 1 51  ? -4.564  20.749  13.078  1.00 253.95 ? 71   ALA A O   1 
ATOM   17   C CB  . ALA A 1 51  ? -3.515  22.988  15.029  1.00 214.49 ? 71   ALA A CB  1 
ATOM   18   N N   . VAL A 1 52  ? -5.145  20.076  15.156  1.00 238.82 ? 72   VAL A N   1 
ATOM   19   C CA  . VAL A 1 52  ? -6.221  19.204  14.676  1.00 247.89 ? 72   VAL A CA  1 
ATOM   20   C C   . VAL A 1 52  ? -7.496  19.983  14.355  1.00 236.47 ? 72   VAL A C   1 
ATOM   21   O O   . VAL A 1 52  ? -8.289  19.529  13.532  1.00 235.16 ? 72   VAL A O   1 
ATOM   22   C CB  . VAL A 1 52  ? -6.534  18.082  15.686  1.00 216.36 ? 72   VAL A CB  1 
ATOM   23   C CG1 . VAL A 1 52  ? -7.144  18.652  16.885  1.00 227.15 ? 72   VAL A CG1 1 
ATOM   24   C CG2 . VAL A 1 52  ? -7.501  17.063  15.109  1.00 202.16 ? 72   VAL A CG2 1 
ATOM   25   N N   . ASN A 1 53  ? -7.752  21.130  15.007  1.00 218.03 ? 73   ASN A N   1 
ATOM   26   C CA  . ASN A 1 53  ? -8.954  21.907  14.686  1.00 221.37 ? 73   ASN A CA  1 
ATOM   27   C C   . ASN A 1 53  ? -8.770  22.681  13.384  1.00 220.53 ? 73   ASN A C   1 
ATOM   28   O O   . ASN A 1 53  ? -9.705  22.768  12.575  1.00 215.64 ? 73   ASN A O   1 
ATOM   29   C CB  . ASN A 1 53  ? -9.320  22.879  15.813  1.00 206.52 ? 73   ASN A CB  1 
ATOM   30   C CG  . ASN A 1 53  ? -10.438 23.838  15.421  1.00 192.08 ? 73   ASN A CG  1 
ATOM   31   O OD1 . ASN A 1 53  ? -11.185 23.588  14.476  1.00 205.67 ? 73   ASN A OD1 1 
ATOM   32   N ND2 . ASN A 1 53  ? -10.558 24.937  16.155  1.00 191.45 ? 73   ASN A ND2 1 
ATOM   33   N N   . PRO A 1 54  ? -7.610  23.304  13.164  1.00 232.37 ? 74   PRO A N   1 
ATOM   34   C CA  . PRO A 1 54  ? -7.337  23.847  11.824  1.00 240.56 ? 74   PRO A CA  1 
ATOM   35   C C   . PRO A 1 54  ? -7.373  22.771  10.750  1.00 207.92 ? 74   PRO A C   1 
ATOM   36   O O   . PRO A 1 54  ? -7.940  22.990  9.670   1.00 218.33 ? 74   PRO A O   1 
ATOM   37   C CB  . PRO A 1 54  ? -5.946  24.480  11.995  1.00 221.09 ? 74   PRO A CB  1 
ATOM   38   C CG  . PRO A 1 54  ? -5.863  24.783  13.470  1.00 218.83 ? 74   PRO A CG  1 
ATOM   39   C CD  . PRO A 1 54  ? -6.509  23.591  14.096  1.00 212.13 ? 74   PRO A CD  1 
ATOM   40   N N   . TRP A 1 55  ? -6.826  21.586  11.044  1.00 209.02 ? 75   TRP A N   1 
ATOM   41   C CA  . TRP A 1 55  ? -6.992  20.447  10.147  1.00 219.51 ? 75   TRP A CA  1 
ATOM   42   C C   . TRP A 1 55  ? -8.463  20.127  9.943   1.00 207.82 ? 75   TRP A C   1 
ATOM   43   O O   . TRP A 1 55  ? -8.883  19.768  8.840   1.00 235.71 ? 75   TRP A O   1 
ATOM   44   C CB  . TRP A 1 55  ? -6.291  19.213  10.712  1.00 217.56 ? 75   TRP A CB  1 
ATOM   45   C CG  . TRP A 1 55  ? -4.865  19.041  10.333  1.00 211.53 ? 75   TRP A CG  1 
ATOM   46   C CD1 . TRP A 1 55  ? -4.244  19.478  9.198   1.00 222.86 ? 75   TRP A CD1 1 
ATOM   47   C CD2 . TRP A 1 55  ? -3.871  18.366  11.101  1.00 242.70 ? 75   TRP A CD2 1 
ATOM   48   N NE1 . TRP A 1 55  ? -2.920  19.115  9.217   1.00 235.78 ? 75   TRP A NE1 1 
ATOM   49   C CE2 . TRP A 1 55  ? -2.668  18.429  10.376  1.00 238.27 ? 75   TRP A CE2 1 
ATOM   50   C CE3 . TRP A 1 55  ? -3.882  17.713  12.336  1.00 225.36 ? 75   TRP A CE3 1 
ATOM   51   C CZ2 . TRP A 1 55  ? -1.490  17.869  10.846  1.00 239.98 ? 75   TRP A CZ2 1 
ATOM   52   C CZ3 . TRP A 1 55  ? -2.717  17.160  12.799  1.00 232.37 ? 75   TRP A CZ3 1 
ATOM   53   C CH2 . TRP A 1 55  ? -1.536  17.244  12.061  1.00 229.30 ? 75   TRP A CH2 1 
ATOM   54   N N   . ASP A 1 56  ? -9.252  20.227  11.013  1.00 212.04 ? 76   ASP A N   1 
ATOM   55   C CA  . ASP A 1 56  ? -10.655 19.840  10.974  1.00 196.33 ? 76   ASP A CA  1 
ATOM   56   C C   . ASP A 1 56  ? -11.449 20.763  10.063  1.00 201.38 ? 76   ASP A C   1 
ATOM   57   O O   . ASP A 1 56  ? -12.240 20.305  9.233   1.00 216.74 ? 76   ASP A O   1 
ATOM   58   C CB  . ASP A 1 56  ? -11.225 19.857  12.392  1.00 203.00 ? 76   ASP A CB  1 
ATOM   59   C CG  . ASP A 1 56  ? -12.681 19.465  12.441  1.00 230.17 ? 76   ASP A CG  1 
ATOM   60   O OD1 . ASP A 1 56  ? -13.004 18.299  12.129  1.00 210.17 ? 76   ASP A OD1 1 
ATOM   61   O OD2 . ASP A 1 56  ? -13.501 20.327  12.804  1.00 226.84 ? 76   ASP A OD2 1 
ATOM   62   N N   . VAL A 1 57  ? -11.244 22.071  10.199  1.00 190.69 ? 77   VAL A N   1 
ATOM   63   C CA  . VAL A 1 57  ? -11.926 23.013  9.316   1.00 221.19 ? 77   VAL A CA  1 
ATOM   64   C C   . VAL A 1 57  ? -11.422 22.858  7.885   1.00 209.57 ? 77   VAL A C   1 
ATOM   65   O O   . VAL A 1 57  ? -12.197 22.967  6.921   1.00 200.02 ? 77   VAL A O   1 
ATOM   66   C CB  . VAL A 1 57  ? -11.758 24.457  9.825   1.00 228.97 ? 77   VAL A CB  1 
ATOM   67   C CG1 . VAL A 1 57  ? -12.342 24.602  11.221  1.00 222.38 ? 77   VAL A CG1 1 
ATOM   68   C CG2 . VAL A 1 57  ? -10.296 24.873  9.808   1.00 212.45 ? 77   VAL A CG2 1 
ATOM   69   N N   . LEU A 1 58  ? -10.118 22.608  7.720   1.00 201.78 ? 78   LEU A N   1 
ATOM   70   C CA  . LEU A 1 58  ? -9.571  22.353  6.392   1.00 199.05 ? 78   LEU A CA  1 
ATOM   71   C C   . LEU A 1 58  ? -10.309 21.204  5.721   1.00 178.72 ? 78   LEU A C   1 
ATOM   72   O O   . LEU A 1 58  ? -10.825 21.337  4.605   1.00 176.40 ? 78   LEU A O   1 
ATOM   73   C CB  . LEU A 1 58  ? -8.077  22.036  6.511   1.00 193.02 ? 78   LEU A CB  1 
ATOM   74   C CG  . LEU A 1 58  ? -7.267  21.744  5.244   1.00 187.93 ? 78   LEU A CG  1 
ATOM   75   C CD1 . LEU A 1 58  ? -5.790  21.643  5.590   1.00 187.61 ? 78   LEU A CD1 1 
ATOM   76   C CD2 . LEU A 1 58  ? -7.716  20.471  4.539   1.00 194.01 ? 78   LEU A CD2 1 
ATOM   77   N N   . LEU A 1 59  ? -10.358 20.056  6.393   1.00 193.33 ? 79   LEU A N   1 
ATOM   78   C CA  . LEU A 1 59  ? -11.038 18.903  5.824   1.00 178.33 ? 79   LEU A CA  1 
ATOM   79   C C   . LEU A 1 59  ? -12.532 19.157  5.678   1.00 204.24 ? 79   LEU A C   1 
ATOM   80   O O   . LEU A 1 59  ? -13.164 18.586  4.790   1.00 187.62 ? 79   LEU A O   1 
ATOM   81   C CB  . LEU A 1 59  ? -10.772 17.656  6.672   1.00 200.33 ? 79   LEU A CB  1 
ATOM   82   C CG  . LEU A 1 59  ? -10.980 17.733  8.186   1.00 200.16 ? 79   LEU A CG  1 
ATOM   83   C CD1 . LEU A 1 59  ? -12.436 17.544  8.583   1.00 207.44 ? 79   LEU A CD1 1 
ATOM   84   C CD2 . LEU A 1 59  ? -10.093 16.710  8.891   1.00 209.50 ? 79   LEU A CD2 1 
ATOM   85   N N   . CYS A 1 60  ? -13.111 20.026  6.509   1.00 206.68 ? 80   CYS A N   1 
ATOM   86   C CA  . CYS A 1 60  ? -14.520 20.366  6.339   1.00 186.06 ? 80   CYS A CA  1 
ATOM   87   C C   . CYS A 1 60  ? -14.755 21.049  4.999   1.00 204.37 ? 80   CYS A C   1 
ATOM   88   O O   . CYS A 1 60  ? -15.656 20.669  4.238   1.00 197.86 ? 80   CYS A O   1 
ATOM   89   C CB  . CYS A 1 60  ? -14.985 21.270  7.477   1.00 228.19 ? 80   CYS A CB  1 
ATOM   90   S SG  . CYS A 1 60  ? -16.608 21.993  7.167   1.00 259.49 ? 80   CYS A SG  1 
ATOM   91   N N   . VAL A 1 61  ? -13.947 22.066  4.695   1.00 184.92 ? 81   VAL A N   1 
ATOM   92   C CA  . VAL A 1 61  ? -14.095 22.751  3.412   1.00 188.67 ? 81   VAL A CA  1 
ATOM   93   C C   . VAL A 1 61  ? -13.774 21.797  2.266   1.00 187.64 ? 81   VAL A C   1 
ATOM   94   O O   . VAL A 1 61  ? -14.450 21.795  1.227   1.00 181.69 ? 81   VAL A O   1 
ATOM   95   C CB  . VAL A 1 61  ? -13.225 24.024  3.363   1.00 179.07 ? 81   VAL A CB  1 
ATOM   96   C CG1 . VAL A 1 61  ? -13.704 25.031  4.400   1.00 183.91 ? 81   VAL A CG1 1 
ATOM   97   C CG2 . VAL A 1 61  ? -11.752 23.712  3.577   1.00 182.40 ? 81   VAL A CG2 1 
ATOM   98   N N   . SER A 1 62  ? -12.754 20.954  2.443   1.00 187.35 ? 82   SER A N   1 
ATOM   99   C CA  . SER A 1 62  ? -12.387 20.016  1.387   1.00 159.61 ? 82   SER A CA  1 
ATOM   100  C C   . SER A 1 62  ? -13.516 19.029  1.110   1.00 174.88 ? 82   SER A C   1 
ATOM   101  O O   . SER A 1 62  ? -13.773 18.677  -0.045  1.00 177.05 ? 82   SER A O   1 
ATOM   102  C CB  . SER A 1 62  ? -11.103 19.278  1.765   1.00 161.60 ? 82   SER A CB  1 
ATOM   103  O OG  . SER A 1 62  ? -10.053 20.189  2.041   1.00 161.83 ? 82   SER A OG  1 
ATOM   104  N N   . GLY A 1 63  ? -14.204 18.571  2.158   1.00 153.65 ? 83   GLY A N   1 
ATOM   105  C CA  . GLY A 1 63  ? -15.302 17.641  1.967   1.00 162.34 ? 83   GLY A CA  1 
ATOM   106  C C   . GLY A 1 63  ? -16.538 18.298  1.398   1.00 154.65 ? 83   GLY A C   1 
ATOM   107  O O   . GLY A 1 63  ? -17.302 17.659  0.672   1.00 163.87 ? 83   GLY A O   1 
ATOM   108  N N   . THR A 1 64  ? -16.758 19.573  1.721   1.00 174.54 ? 84   THR A N   1 
ATOM   109  C CA  . THR A 1 64  ? -17.760 20.345  0.994   1.00 178.26 ? 84   THR A CA  1 
ATOM   110  C C   . THR A 1 64  ? -17.456 20.331  -0.501  1.00 167.99 ? 84   THR A C   1 
ATOM   111  O O   . THR A 1 64  ? -18.331 20.037  -1.330  1.00 165.72 ? 84   THR A O   1 
ATOM   112  C CB  . THR A 1 64  ? -17.801 21.775  1.539   1.00 183.07 ? 84   THR A CB  1 
ATOM   113  O OG1 . THR A 1 64  ? -18.106 21.746  2.942   1.00 207.35 ? 84   THR A OG1 1 
ATOM   114  C CG2 . THR A 1 64  ? -18.852 22.597  0.814   1.00 171.18 ? 84   THR A CG2 1 
ATOM   115  N N   . VAL A 1 65  ? -16.198 20.608  -0.855  1.00 179.15 ? 85   VAL A N   1 
ATOM   116  C CA  . VAL A 1 65  ? -15.776 20.571  -2.255  1.00 177.24 ? 85   VAL A CA  1 
ATOM   117  C C   . VAL A 1 65  ? -16.067 19.200  -2.861  1.00 176.08 ? 85   VAL A C   1 
ATOM   118  O O   . VAL A 1 65  ? -16.621 19.081  -3.967  1.00 166.34 ? 85   VAL A O   1 
ATOM   119  C CB  . VAL A 1 65  ? -14.278 20.918  -2.357  1.00 153.72 ? 85   VAL A CB  1 
ATOM   120  C CG1 . VAL A 1 65  ? -13.788 20.787  -3.787  1.00 148.61 ? 85   VAL A CG1 1 
ATOM   121  C CG2 . VAL A 1 65  ? -14.003 22.319  -1.812  1.00 162.03 ? 85   VAL A CG2 1 
ATOM   122  N N   . ILE A 1 66  ? -15.681 18.147  -2.138  1.00 184.36 ? 86   ILE A N   1 
ATOM   123  C CA  . ILE A 1 66  ? -15.805 16.780  -2.637  1.00 186.58 ? 86   ILE A CA  1 
ATOM   124  C C   . ILE A 1 66  ? -17.265 16.434  -2.895  1.00 177.34 ? 86   ILE A C   1 
ATOM   125  O O   . ILE A 1 66  ? -17.622 15.904  -3.957  1.00 194.59 ? 86   ILE A O   1 
ATOM   126  C CB  . ILE A 1 66  ? -15.161 15.801  -1.636  1.00 176.17 ? 86   ILE A CB  1 
ATOM   127  C CG1 . ILE A 1 66  ? -13.636 15.914  -1.705  1.00 152.55 ? 86   ILE A CG1 1 
ATOM   128  C CG2 . ILE A 1 66  ? -15.632 14.374  -1.891  1.00 177.47 ? 86   ILE A CG2 1 
ATOM   129  C CD1 . ILE A 1 66  ? -12.911 15.237  -0.563  1.00 147.98 ? 86   ILE A CD1 1 
ATOM   130  N N   . ALA A 1 67  ? -18.130 16.716  -1.919  1.00 183.83 ? 87   ALA A N   1 
ATOM   131  C CA  . ALA A 1 67  ? -19.544 16.408  -2.076  1.00 177.40 ? 87   ALA A CA  1 
ATOM   132  C C   . ALA A 1 67  ? -20.137 17.165  -3.256  1.00 187.87 ? 87   ALA A C   1 
ATOM   133  O O   . ALA A 1 67  ? -20.919 16.602  -4.032  1.00 175.38 ? 87   ALA A O   1 
ATOM   134  C CB  . ALA A 1 67  ? -20.299 16.738  -0.789  1.00 180.17 ? 87   ALA A CB  1 
ATOM   135  N N   . GLY A 1 68  ? -19.773 18.440  -3.416  1.00 174.17 ? 88   GLY A N   1 
ATOM   136  C CA  . GLY A 1 68  ? -20.314 19.199  -4.534  1.00 176.18 ? 88   GLY A CA  1 
ATOM   137  C C   . GLY A 1 68  ? -19.940 18.601  -5.879  1.00 177.37 ? 88   GLY A C   1 
ATOM   138  O O   . GLY A 1 68  ? -20.801 18.383  -6.743  1.00 184.32 ? 88   GLY A O   1 
ATOM   139  N N   . GLU A 1 69  ? -18.650 18.311  -6.071  1.00 184.97 ? 89   GLU A N   1 
ATOM   140  C CA  . GLU A 1 69  ? -18.225 17.765  -7.359  1.00 153.91 ? 89   GLU A CA  1 
ATOM   141  C C   . GLU A 1 69  ? -18.858 16.399  -7.614  1.00 167.79 ? 89   GLU A C   1 
ATOM   142  O O   . GLU A 1 69  ? -19.304 16.107  -8.735  1.00 181.55 ? 89   GLU A O   1 
ATOM   143  C CB  . GLU A 1 69  ? -16.697 17.691  -7.432  1.00 150.69 ? 89   GLU A CB  1 
ATOM   144  C CG  . GLU A 1 69  ? -16.010 16.978  -6.280  1.00 166.36 ? 89   GLU A CG  1 
ATOM   145  C CD  . GLU A 1 69  ? -14.506 17.196  -6.287  1.00 179.83 ? 89   GLU A CD  1 
ATOM   146  O OE1 . GLU A 1 69  ? -13.876 16.981  -7.344  1.00 151.14 ? 89   GLU A OE1 1 
ATOM   147  O OE2 . GLU A 1 69  ? -13.956 17.597  -5.240  1.00 190.47 ? 89   GLU A OE2 1 
ATOM   148  N N   . ASN A 1 70  ? -18.927 15.552  -6.582  1.00 169.67 ? 90   ASN A N   1 
ATOM   149  C CA  . ASN A 1 70  ? -19.532 14.236  -6.759  1.00 161.84 ? 90   ASN A CA  1 
ATOM   150  C C   . ASN A 1 70  ? -21.007 14.343  -7.128  1.00 165.18 ? 90   ASN A C   1 
ATOM   151  O O   . ASN A 1 70  ? -21.496 13.594  -7.984  1.00 175.59 ? 90   ASN A O   1 
ATOM   152  C CB  . ASN A 1 70  ? -19.363 13.408  -5.487  1.00 183.08 ? 90   ASN A CB  1 
ATOM   153  C CG  . ASN A 1 70  ? -17.920 13.044  -5.215  1.00 167.74 ? 90   ASN A CG  1 
ATOM   154  O OD1 . ASN A 1 70  ? -17.391 13.323  -4.141  1.00 173.63 ? 90   ASN A OD1 1 
ATOM   155  N ND2 . ASN A 1 70  ? -17.275 12.413  -6.190  1.00 147.10 ? 90   ASN A ND2 1 
ATOM   156  N N   . ALA A 1 71  ? -21.739 15.254  -6.481  1.00 180.41 ? 91   ALA A N   1 
ATOM   157  C CA  . ALA A 1 71  ? -23.148 15.433  -6.817  1.00 199.87 ? 91   ALA A CA  1 
ATOM   158  C C   . ALA A 1 71  ? -23.307 15.893  -8.258  1.00 175.95 ? 91   ALA A C   1 
ATOM   159  O O   . ALA A 1 71  ? -24.199 15.423  -8.978  1.00 170.60 ? 91   ALA A O   1 
ATOM   160  C CB  . ALA A 1 71  ? -23.794 16.437  -5.863  1.00 199.77 ? 91   ALA A CB  1 
ATOM   161  N N   . LEU A 1 72  ? -22.448 16.816  -8.696  1.00 181.50 ? 92   LEU A N   1 
ATOM   162  C CA  . LEU A 1 72  ? -22.481 17.246  -10.090 1.00 167.70 ? 92   LEU A CA  1 
ATOM   163  C C   . LEU A 1 72  ? -22.314 16.056  -11.030 1.00 154.61 ? 92   LEU A C   1 
ATOM   164  O O   . LEU A 1 72  ? -23.057 15.908  -12.011 1.00 147.23 ? 92   LEU A O   1 
ATOM   165  C CB  . LEU A 1 72  ? -21.388 18.287  -10.333 1.00 163.62 ? 92   LEU A CB  1 
ATOM   166  C CG  . LEU A 1 72  ? -21.113 18.659  -11.789 1.00 160.96 ? 92   LEU A CG  1 
ATOM   167  C CD1 . LEU A 1 72  ? -22.390 19.120  -12.474 1.00 167.00 ? 92   LEU A CD1 1 
ATOM   168  C CD2 . LEU A 1 72  ? -20.037 19.735  -11.865 1.00 153.99 ? 92   LEU A CD2 1 
ATOM   169  N N   . VAL A 1 73  ? -21.342 15.191  -10.740 1.00 153.17 ? 93   VAL A N   1 
ATOM   170  C CA  . VAL A 1 73  ? -21.087 14.053  -11.622 1.00 141.68 ? 93   VAL A CA  1 
ATOM   171  C C   . VAL A 1 73  ? -22.280 13.101  -11.639 1.00 156.34 ? 93   VAL A C   1 
ATOM   172  O O   . VAL A 1 73  ? -22.661 12.574  -12.695 1.00 148.04 ? 93   VAL A O   1 
ATOM   173  C CB  . VAL A 1 73  ? -19.798 13.329  -11.200 1.00 147.58 ? 93   VAL A CB  1 
ATOM   174  C CG1 . VAL A 1 73  ? -19.602 12.078  -12.043 1.00 156.72 ? 93   VAL A CG1 1 
ATOM   175  C CG2 . VAL A 1 73  ? -18.605 14.263  -11.327 1.00 146.24 ? 93   VAL A CG2 1 
ATOM   176  N N   . VAL A 1 74  ? -22.863 12.833  -10.470 1.00 161.83 ? 94   VAL A N   1 
ATOM   177  C CA  . VAL A 1 74  ? -24.019 11.942  -10.424 1.00 160.13 ? 94   VAL A CA  1 
ATOM   178  C C   . VAL A 1 74  ? -25.151 12.519  -11.256 1.00 182.16 ? 94   VAL A C   1 
ATOM   179  O O   . VAL A 1 74  ? -25.850 11.793  -11.976 1.00 200.57 ? 94   VAL A O   1 
ATOM   180  C CB  . VAL A 1 74  ? -24.464 11.695  -8.971  1.00 157.24 ? 94   VAL A CB  1 
ATOM   181  C CG1 . VAL A 1 74  ? -25.696 10.796  -8.948  1.00 152.45 ? 94   VAL A CG1 1 
ATOM   182  C CG2 . VAL A 1 74  ? -23.337 11.078  -8.161  1.00 169.20 ? 94   VAL A CG2 1 
ATOM   183  N N   . ALA A 1 75  ? -25.355 13.835  -11.165 1.00 175.87 ? 95   ALA A N   1 
ATOM   184  C CA  . ALA A 1 75  ? -26.386 14.476  -11.971 1.00 183.42 ? 95   ALA A CA  1 
ATOM   185  C C   . ALA A 1 75  ? -26.105 14.299  -13.458 1.00 193.03 ? 95   ALA A C   1 
ATOM   186  O O   . ALA A 1 75  ? -27.022 14.023  -14.240 1.00 173.77 ? 95   ALA A O   1 
ATOM   187  C CB  . ALA A 1 75  ? -26.484 15.959  -11.613 1.00 176.86 ? 95   ALA A CB  1 
ATOM   188  N N   . LEU A 1 76  ? -24.843 14.452  -13.869 1.00 180.28 ? 96   LEU A N   1 
ATOM   189  C CA  . LEU A 1 76  ? -24.518 14.286  -15.284 1.00 154.16 ? 96   LEU A CA  1 
ATOM   190  C C   . LEU A 1 76  ? -24.802 12.864  -15.757 1.00 172.08 ? 96   LEU A C   1 
ATOM   191  O O   . LEU A 1 76  ? -25.350 12.663  -16.847 1.00 179.43 ? 96   LEU A O   1 
ATOM   192  C CB  . LEU A 1 76  ? -23.056 14.642  -15.551 1.00 144.71 ? 96   LEU A CB  1 
ATOM   193  C CG  . LEU A 1 76  ? -22.719 16.107  -15.833 1.00 153.68 ? 96   LEU A CG  1 
ATOM   194  C CD1 . LEU A 1 76  ? -21.270 16.223  -16.282 1.00 168.46 ? 96   LEU A CD1 1 
ATOM   195  C CD2 . LEU A 1 76  ? -23.645 16.714  -16.879 1.00 201.42 ? 96   LEU A CD2 1 
ATOM   196  N N   . ILE A 1 77  ? -24.430 11.862  -14.959 1.00 185.63 ? 97   ILE A N   1 
ATOM   197  C CA  . ILE A 1 77  ? -24.668 10.484  -15.384 1.00 185.89 ? 97   ILE A CA  1 
ATOM   198  C C   . ILE A 1 77  ? -26.161 10.190  -15.431 1.00 181.70 ? 97   ILE A C   1 
ATOM   199  O O   . ILE A 1 77  ? -26.640 9.493   -16.334 1.00 184.75 ? 97   ILE A O   1 
ATOM   200  C CB  . ILE A 1 77  ? -23.930 9.490   -14.471 1.00 174.97 ? 97   ILE A CB  1 
ATOM   201  C CG1 . ILE A 1 77  ? -22.496 9.291   -14.959 1.00 150.67 ? 97   ILE A CG1 1 
ATOM   202  C CG2 . ILE A 1 77  ? -24.651 8.142   -14.447 1.00 162.74 ? 97   ILE A CG2 1 
ATOM   203  C CD1 . ILE A 1 77  ? -21.679 10.560  -14.999 1.00 172.66 ? 97   ILE A CD1 1 
ATOM   204  N N   . ALA A 1 78  ? -26.920 10.701  -14.459 1.00 206.21 ? 98   ALA A N   1 
ATOM   205  C CA  . ALA A 1 78  ? -28.349 10.414  -14.428 1.00 208.35 ? 98   ALA A CA  1 
ATOM   206  C C   . ALA A 1 78  ? -29.098 11.149  -15.532 1.00 194.23 ? 98   ALA A C   1 
ATOM   207  O O   . ALA A 1 78  ? -30.119 10.652  -16.021 1.00 194.22 ? 98   ALA A O   1 
ATOM   208  C CB  . ALA A 1 78  ? -28.928 10.781  -13.062 1.00 188.48 ? 98   ALA A CB  1 
ATOM   209  N N   . SER A 1 79  ? -28.608 12.320  -15.941 1.00 183.97 ? 99   SER A N   1 
ATOM   210  C CA  . SER A 1 79  ? -29.313 13.154  -16.906 1.00 193.90 ? 99   SER A CA  1 
ATOM   211  C C   . SER A 1 79  ? -28.885 12.900  -18.344 1.00 183.93 ? 99   SER A C   1 
ATOM   212  O O   . SER A 1 79  ? -29.681 13.121  -19.264 1.00 233.11 ? 99   SER A O   1 
ATOM   213  C CB  . SER A 1 79  ? -29.095 14.635  -16.580 1.00 210.30 ? 99   SER A CB  1 
ATOM   214  O OG  . SER A 1 79  ? -27.745 15.012  -16.797 1.00 220.64 ? 99   SER A OG  1 
ATOM   215  N N   . THR A 1 80  ? -27.652 12.445  -18.566 1.00 166.60 ? 100  THR A N   1 
ATOM   216  C CA  . THR A 1 80  ? -27.143 12.269  -19.919 1.00 205.83 ? 100  THR A CA  1 
ATOM   217  C C   . THR A 1 80  ? -27.401 10.838  -20.373 1.00 196.23 ? 100  THR A C   1 
ATOM   218  O O   . THR A 1 80  ? -26.810 9.906   -19.804 1.00 192.13 ? 100  THR A O   1 
ATOM   219  C CB  . THR A 1 80  ? -25.654 12.581  -19.977 1.00 220.60 ? 100  THR A CB  1 
ATOM   220  O OG1 . THR A 1 80  ? -25.415 13.901  -19.472 1.00 181.35 ? 100  THR A OG1 1 
ATOM   221  C CG2 . THR A 1 80  ? -25.148 12.489  -21.412 1.00 200.99 ? 100  THR A CG2 1 
ATOM   222  N N   . PRO A 1 81  ? -28.259 10.607  -21.371 1.00 193.02 ? 101  PRO A N   1 
ATOM   223  C CA  . PRO A 1 81  ? -28.419 9.235   -21.880 1.00 197.62 ? 101  PRO A CA  1 
ATOM   224  C C   . PRO A 1 81  ? -27.141 8.677   -22.475 1.00 194.19 ? 101  PRO A C   1 
ATOM   225  O O   . PRO A 1 81  ? -26.894 7.467   -22.380 1.00 213.85 ? 101  PRO A O   1 
ATOM   226  C CB  . PRO A 1 81  ? -29.523 9.382   -22.935 1.00 213.07 ? 101  PRO A CB  1 
ATOM   227  C CG  . PRO A 1 81  ? -29.387 10.784  -23.412 1.00 219.93 ? 101  PRO A CG  1 
ATOM   228  C CD  . PRO A 1 81  ? -28.981 11.587  -22.206 1.00 214.31 ? 101  PRO A CD  1 
ATOM   229  N N   . ALA A 1 82  ? -26.319 9.531   -23.090 1.00 207.36 ? 102  ALA A N   1 
ATOM   230  C CA  . ALA A 1 82  ? -25.034 9.088   -23.613 1.00 194.50 ? 102  ALA A CA  1 
ATOM   231  C C   . ALA A 1 82  ? -24.136 8.534   -22.516 1.00 237.01 ? 102  ALA A C   1 
ATOM   232  O O   . ALA A 1 82  ? -23.249 7.722   -22.805 1.00 232.89 ? 102  ALA A O   1 
ATOM   233  C CB  . ALA A 1 82  ? -24.338 10.249  -24.326 1.00 163.09 ? 102  ALA A CB  1 
ATOM   234  N N   . LEU A 1 83  ? -24.351 8.948   -21.267 1.00 182.03 ? 103  LEU A N   1 
ATOM   235  C CA  . LEU A 1 83  ? -23.581 8.481   -20.123 1.00 179.42 ? 103  LEU A CA  1 
ATOM   236  C C   . LEU A 1 83  ? -24.267 7.332   -19.390 1.00 198.34 ? 103  LEU A C   1 
ATOM   237  O O   . LEU A 1 83  ? -23.881 7.011   -18.260 1.00 197.13 ? 103  LEU A O   1 
ATOM   238  C CB  . LEU A 1 83  ? -23.329 9.642   -19.157 1.00 165.93 ? 103  LEU A CB  1 
ATOM   239  C CG  . LEU A 1 83  ? -22.542 10.836  -19.709 1.00 171.19 ? 103  LEU A CG  1 
ATOM   240  C CD1 . LEU A 1 83  ? -22.476 11.967  -18.686 1.00 158.21 ? 103  LEU A CD1 1 
ATOM   241  C CD2 . LEU A 1 83  ? -21.142 10.414  -20.131 1.00 168.86 ? 103  LEU A CD2 1 
ATOM   242  N N   . ARG A 1 84  ? -25.271 6.708   -20.003 1.00 183.06 ? 104  ARG A N   1 
ATOM   243  C CA  . ARG A 1 84  ? -26.042 5.648   -19.366 1.00 172.06 ? 104  ARG A CA  1 
ATOM   244  C C   . ARG A 1 84  ? -25.495 4.258   -19.656 1.00 192.33 ? 104  ARG A C   1 
ATOM   245  O O   . ARG A 1 84  ? -26.140 3.266   -19.298 1.00 193.63 ? 104  ARG A O   1 
ATOM   246  C CB  . ARG A 1 84  ? -27.507 5.721   -19.803 1.00 189.95 ? 104  ARG A CB  1 
ATOM   247  C CG  . ARG A 1 84  ? -28.296 6.837   -19.144 1.00 218.03 ? 104  ARG A CG  1 
ATOM   248  C CD  . ARG A 1 84  ? -28.299 6.678   -17.636 1.00 212.63 ? 104  ARG A CD  1 
ATOM   249  N NE  . ARG A 1 84  ? -29.425 7.353   -17.005 1.00 210.58 ? 104  ARG A NE  1 
ATOM   250  C CZ  . ARG A 1 84  ? -29.611 7.425   -15.694 1.00 200.68 ? 104  ARG A CZ  1 
ATOM   251  N NH1 . ARG A 1 84  ? -28.750 6.890   -14.843 1.00 186.26 ? 104  ARG A NH1 1 
ATOM   252  N NH2 . ARG A 1 84  ? -30.683 8.057   -15.225 1.00 200.41 ? 104  ARG A NH2 1 
ATOM   253  N N   . THR A 1 85  ? -24.337 4.159   -20.298 1.00 216.98 ? 105  THR A N   1 
ATOM   254  C CA  . THR A 1 85  ? -23.738 2.858   -20.525 1.00 172.53 ? 105  THR A CA  1 
ATOM   255  C C   . THR A 1 85  ? -23.315 2.240   -19.192 1.00 188.59 ? 105  THR A C   1 
ATOM   256  O O   . THR A 1 85  ? -23.048 2.958   -18.224 1.00 172.97 ? 105  THR A O   1 
ATOM   257  C CB  . THR A 1 85  ? -22.527 2.974   -21.447 1.00 166.21 ? 105  THR A CB  1 
ATOM   258  O OG1 . THR A 1 85  ? -22.110 1.668   -21.864 1.00 183.33 ? 105  THR A OG1 1 
ATOM   259  C CG2 . THR A 1 85  ? -21.375 3.645   -20.733 1.00 153.00 ? 105  THR A CG2 1 
ATOM   260  N N   . PRO A 1 86  ? -23.265 0.906   -19.114 1.00 155.37 ? 106  PRO A N   1 
ATOM   261  C CA  . PRO A 1 86  ? -22.757 0.252   -17.903 1.00 138.45 ? 106  PRO A CA  1 
ATOM   262  C C   . PRO A 1 86  ? -21.565 0.952   -17.276 1.00 135.72 ? 106  PRO A C   1 
ATOM   263  O O   . PRO A 1 86  ? -21.596 1.283   -16.087 1.00 142.56 ? 106  PRO A O   1 
ATOM   264  C CB  . PRO A 1 86  ? -22.380 -1.138  -18.421 1.00 170.91 ? 106  PRO A CB  1 
ATOM   265  C CG  . PRO A 1 86  ? -23.453 -1.422  -19.416 1.00 152.07 ? 106  PRO A CG  1 
ATOM   266  C CD  . PRO A 1 86  ? -23.758 -0.089  -20.086 1.00 165.59 ? 106  PRO A CD  1 
ATOM   267  N N   . MET A 1 87  ? -20.517 1.195   -18.064 1.00 157.33 ? 107  MET A N   1 
ATOM   268  C CA  . MET A 1 87  ? -19.316 1.816   -17.520 1.00 125.64 ? 107  MET A CA  1 
ATOM   269  C C   . MET A 1 87  ? -19.656 3.108   -16.789 1.00 143.12 ? 107  MET A C   1 
ATOM   270  O O   . MET A 1 87  ? -19.272 3.301   -15.632 1.00 144.87 ? 107  MET A O   1 
ATOM   271  C CB  . MET A 1 87  ? -18.313 2.090   -18.643 1.00 146.74 ? 107  MET A CB  1 
ATOM   272  C CG  . MET A 1 87  ? -17.050 2.817   -18.191 1.00 134.31 ? 107  MET A CG  1 
ATOM   273  S SD  . MET A 1 87  ? -16.267 3.714   -19.539 1.00 140.50 ? 107  MET A SD  1 
ATOM   274  C CE  . MET A 1 87  ? -15.153 4.776   -18.628 1.00 138.74 ? 107  MET A CE  1 
ATOM   275  N N   . PHE A 1 88  ? -20.386 4.003   -17.449 1.00 152.61 ? 108  PHE A N   1 
ATOM   276  C CA  . PHE A 1 88  ? -20.642 5.306   -16.852 1.00 146.31 ? 108  PHE A CA  1 
ATOM   277  C C   . PHE A 1 88  ? -21.691 5.240   -15.753 1.00 144.77 ? 108  PHE A C   1 
ATOM   278  O O   . PHE A 1 88  ? -21.675 6.073   -14.844 1.00 133.68 ? 108  PHE A O   1 
ATOM   279  C CB  . PHE A 1 88  ? -21.045 6.305   -17.932 1.00 168.60 ? 108  PHE A CB  1 
ATOM   280  C CG  . PHE A 1 88  ? -19.883 6.823   -18.726 1.00 174.21 ? 108  PHE A CG  1 
ATOM   281  C CD1 . PHE A 1 88  ? -19.167 7.924   -18.292 1.00 169.93 ? 108  PHE A CD1 1 
ATOM   282  C CD2 . PHE A 1 88  ? -19.492 6.198   -19.895 1.00 145.63 ? 108  PHE A CD2 1 
ATOM   283  C CE1 . PHE A 1 88  ? -18.093 8.398   -19.018 1.00 179.01 ? 108  PHE A CE1 1 
ATOM   284  C CE2 . PHE A 1 88  ? -18.422 6.666   -20.623 1.00 173.00 ? 108  PHE A CE2 1 
ATOM   285  C CZ  . PHE A 1 88  ? -17.722 7.767   -20.185 1.00 174.25 ? 108  PHE A CZ  1 
ATOM   286  N N   . VAL A 1 89  ? -22.591 4.258   -15.793 1.00 142.43 ? 109  VAL A N   1 
ATOM   287  C CA  . VAL A 1 89  ? -23.497 4.052   -14.666 1.00 156.00 ? 109  VAL A CA  1 
ATOM   288  C C   . VAL A 1 89  ? -22.701 3.666   -13.422 1.00 142.68 ? 109  VAL A C   1 
ATOM   289  O O   . VAL A 1 89  ? -22.920 4.196   -12.324 1.00 144.74 ? 109  VAL A O   1 
ATOM   290  C CB  . VAL A 1 89  ? -24.556 2.993   -15.020 1.00 189.57 ? 109  VAL A CB  1 
ATOM   291  C CG1 . VAL A 1 89  ? -25.348 2.598   -13.787 1.00 156.77 ? 109  VAL A CG1 1 
ATOM   292  C CG2 . VAL A 1 89  ? -25.487 3.519   -16.105 1.00 197.08 ? 109  VAL A CG2 1 
ATOM   293  N N   . LEU A 1 90  ? -21.747 2.748   -13.583 1.00 173.86 ? 110  LEU A N   1 
ATOM   294  C CA  . LEU A 1 90  ? -20.884 2.368   -12.468 1.00 128.55 ? 110  LEU A CA  1 
ATOM   295  C C   . LEU A 1 90  ? -20.039 3.549   -12.004 1.00 131.37 ? 110  LEU A C   1 
ATOM   296  O O   . LEU A 1 90  ? -19.815 3.739   -10.799 1.00 154.69 ? 110  LEU A O   1 
ATOM   297  C CB  . LEU A 1 90  ? -19.994 1.199   -12.888 1.00 107.41 ? 110  LEU A CB  1 
ATOM   298  C CG  . LEU A 1 90  ? -20.738 -0.022  -13.435 1.00 136.91 ? 110  LEU A CG  1 
ATOM   299  C CD1 . LEU A 1 90  ? -19.774 -0.997  -14.084 1.00 142.71 ? 110  LEU A CD1 1 
ATOM   300  C CD2 . LEU A 1 90  ? -21.527 -0.703  -12.338 1.00 139.39 ? 110  LEU A CD2 1 
ATOM   301  N N   . VAL A 1 91  ? -19.549 4.347   -12.951 1.00 140.07 ? 111  VAL A N   1 
ATOM   302  C CA  . VAL A 1 91  ? -18.777 5.532   -12.595 1.00 142.35 ? 111  VAL A CA  1 
ATOM   303  C C   . VAL A 1 91  ? -19.633 6.493   -11.778 1.00 142.63 ? 111  VAL A C   1 
ATOM   304  O O   . VAL A 1 91  ? -19.163 7.098   -10.808 1.00 142.95 ? 111  VAL A O   1 
ATOM   305  C CB  . VAL A 1 91  ? -18.216 6.195   -13.867 1.00 144.57 ? 111  VAL A CB  1 
ATOM   306  C CG1 . VAL A 1 91  ? -17.536 7.505   -13.524 1.00 143.43 ? 111  VAL A CG1 1 
ATOM   307  C CG2 . VAL A 1 91  ? -17.239 5.255   -14.575 1.00 149.86 ? 111  VAL A CG2 1 
ATOM   308  N N   . GLY A 1 92  ? -20.902 6.653   -12.156 1.00 161.45 ? 112  GLY A N   1 
ATOM   309  C CA  . GLY A 1 92  ? -21.808 7.451   -11.352 1.00 146.16 ? 112  GLY A CA  1 
ATOM   310  C C   . GLY A 1 92  ? -22.025 6.870   -9.969  1.00 184.40 ? 112  GLY A C   1 
ATOM   311  O O   . GLY A 1 92  ? -22.190 7.611   -8.997  1.00 189.21 ? 112  GLY A O   1 
ATOM   312  N N   . SER A 1 93  ? -22.038 5.541   -9.859  1.00 154.14 ? 113  SER A N   1 
ATOM   313  C CA  . SER A 1 93  ? -22.128 4.918   -8.540  1.00 153.06 ? 113  SER A CA  1 
ATOM   314  C C   . SER A 1 93  ? -20.931 5.300   -7.673  1.00 160.73 ? 113  SER A C   1 
ATOM   315  O O   . SER A 1 93  ? -21.080 5.636   -6.489  1.00 158.72 ? 113  SER A O   1 
ATOM   316  C CB  . SER A 1 93  ? -22.221 3.400   -8.686  1.00 143.72 ? 113  SER A CB  1 
ATOM   317  O OG  . SER A 1 93  ? -22.089 2.759   -7.430  1.00 141.40 ? 113  SER A OG  1 
ATOM   318  N N   . LEU A 1 94  ? -19.731 5.256   -8.248  1.00 140.36 ? 114  LEU A N   1 
ATOM   319  C CA  . LEU A 1 94  ? -18.554 5.701   -7.504  1.00 151.13 ? 114  LEU A CA  1 
ATOM   320  C C   . LEU A 1 94  ? -18.665 7.176   -7.139  1.00 149.33 ? 114  LEU A C   1 
ATOM   321  O O   . LEU A 1 94  ? -18.238 7.596   -6.055  1.00 135.41 ? 114  LEU A O   1 
ATOM   322  C CB  . LEU A 1 94  ? -17.282 5.462   -8.313  1.00 154.16 ? 114  LEU A CB  1 
ATOM   323  C CG  . LEU A 1 94  ? -16.060 6.226   -7.786  1.00 156.77 ? 114  LEU A CG  1 
ATOM   324  C CD1 . LEU A 1 94  ? -15.745 5.856   -6.337  1.00 162.81 ? 114  LEU A CD1 1 
ATOM   325  C CD2 . LEU A 1 94  ? -14.855 5.978   -8.674  1.00 175.41 ? 114  LEU A CD2 1 
ATOM   326  N N   . ALA A 1 95  ? -19.184 7.987   -8.058  1.00 168.02 ? 115  ALA A N   1 
ATOM   327  C CA  . ALA A 1 95  ? -19.398 9.394   -7.751  1.00 163.75 ? 115  ALA A CA  1 
ATOM   328  C C   . ALA A 1 95  ? -20.304 9.539   -6.541  1.00 144.73 ? 115  ALA A C   1 
ATOM   329  O O   . ALA A 1 95  ? -20.064 10.381  -5.675  1.00 155.62 ? 115  ALA A O   1 
ATOM   330  C CB  . ALA A 1 95  ? -19.995 10.112  -8.959  1.00 180.64 ? 115  ALA A CB  1 
ATOM   331  N N   . THR A 1 96  ? -21.346 8.711   -6.463  1.00 144.14 ? 116  THR A N   1 
ATOM   332  C CA  . THR A 1 96  ? -22.233 8.740   -5.304  1.00 179.60 ? 116  THR A CA  1 
ATOM   333  C C   . THR A 1 96  ? -21.491 8.334   -4.034  1.00 151.61 ? 116  THR A C   1 
ATOM   334  O O   . THR A 1 96  ? -21.725 8.900   -2.961  1.00 149.72 ? 116  THR A O   1 
ATOM   335  C CB  . THR A 1 96  ? -23.436 7.823   -5.540  1.00 197.51 ? 116  THR A CB  1 
ATOM   336  O OG1 . THR A 1 96  ? -24.101 8.201   -6.754  1.00 175.12 ? 116  THR A OG1 1 
ATOM   337  C CG2 . THR A 1 96  ? -24.424 7.910   -4.379  1.00 177.98 ? 116  THR A CG2 1 
ATOM   338  N N   . ALA A 1 97  ? -20.601 7.346   -4.132  1.00 149.94 ? 117  ALA A N   1 
ATOM   339  C CA  . ALA A 1 97  ? -19.833 6.936   -2.956  1.00 161.31 ? 117  ALA A CA  1 
ATOM   340  C C   . ALA A 1 97  ? -18.960 8.080   -2.444  1.00 138.79 ? 117  ALA A C   1 
ATOM   341  O O   . ALA A 1 97  ? -18.914 8.361   -1.239  1.00 157.03 ? 117  ALA A O   1 
ATOM   342  C CB  . ALA A 1 97  ? -18.975 5.714   -3.285  1.00 135.18 ? 117  ALA A CB  1 
ATOM   343  N N   . ASP A 1 98  ? -18.258 8.756   -3.352  1.00 153.97 ? 118  ASP A N   1 
ATOM   344  C CA  . ASP A 1 98  ? -17.432 9.889   -2.942  1.00 157.96 ? 118  ASP A CA  1 
ATOM   345  C C   . ASP A 1 98  ? -18.288 11.052  -2.450  1.00 143.65 ? 118  ASP A C   1 
ATOM   346  O O   . ASP A 1 98  ? -17.880 11.798  -1.547  1.00 140.93 ? 118  ASP A O   1 
ATOM   347  C CB  . ASP A 1 98  ? -16.537 10.324  -4.101  1.00 160.02 ? 118  ASP A CB  1 
ATOM   348  C CG  . ASP A 1 98  ? -15.382 9.368   -4.336  1.00 169.65 ? 118  ASP A CG  1 
ATOM   349  O OD1 . ASP A 1 98  ? -15.270 8.366   -3.597  1.00 164.34 ? 118  ASP A OD1 1 
ATOM   350  O OD2 . ASP A 1 98  ? -14.583 9.621   -5.263  1.00 153.90 ? 118  ASP A OD2 1 
ATOM   351  N N   . LEU A 1 99  ? -19.473 11.222  -3.035  1.00 149.13 ? 119  LEU A N   1 
ATOM   352  C CA  . LEU A 1 99  ? -20.434 12.183  -2.514  1.00 169.67 ? 119  LEU A CA  1 
ATOM   353  C C   . LEU A 1 99  ? -20.748 11.879  -1.060  1.00 168.71 ? 119  LEU A C   1 
ATOM   354  O O   . LEU A 1 99  ? -20.753 12.776  -0.211  1.00 173.72 ? 119  LEU A O   1 
ATOM   355  C CB  . LEU A 1 99  ? -21.707 12.138  -3.359  1.00 158.22 ? 119  LEU A CB  1 
ATOM   356  C CG  . LEU A 1 99  ? -22.884 13.002  -2.917  1.00 176.94 ? 119  LEU A CG  1 
ATOM   357  C CD1 . LEU A 1 99  ? -22.515 14.466  -2.988  1.00 152.02 ? 119  LEU A CD1 1 
ATOM   358  C CD2 . LEU A 1 99  ? -24.095 12.704  -3.783  1.00 164.25 ? 119  LEU A CD2 1 
ATOM   359  N N   . LEU A 1 100 ? -21.017 10.609  -0.761  1.00 154.89 ? 120  LEU A N   1 
ATOM   360  C CA  . LEU A 1 100 ? -21.282 10.210  0.615   1.00 141.65 ? 120  LEU A CA  1 
ATOM   361  C C   . LEU A 1 100 ? -20.087 10.506  1.503   1.00 143.68 ? 120  LEU A C   1 
ATOM   362  O O   . LEU A 1 100 ? -20.250 10.925  2.649   1.00 176.66 ? 120  LEU A O   1 
ATOM   363  C CB  . LEU A 1 100 ? -21.634 8.726   0.680   1.00 160.24 ? 120  LEU A CB  1 
ATOM   364  C CG  . LEU A 1 100 ? -23.128 8.412   0.727   1.00 147.80 ? 120  LEU A CG  1 
ATOM   365  C CD1 . LEU A 1 100 ? -23.821 8.863   -0.550  1.00 177.90 ? 120  LEU A CD1 1 
ATOM   366  C CD2 . LEU A 1 100 ? -23.349 6.926   0.972   1.00 128.26 ? 120  LEU A CD2 1 
ATOM   367  N N   . ALA A 1 101 ? -18.875 10.278  1.000   1.00 152.71 ? 121  ALA A N   1 
ATOM   368  C CA  . ALA A 1 101 ? -17.689 10.623  1.780   1.00 178.45 ? 121  ALA A CA  1 
ATOM   369  C C   . ALA A 1 101 ? -17.702 12.101  2.161   1.00 169.02 ? 121  ALA A C   1 
ATOM   370  O O   . ALA A 1 101 ? -17.560 12.461  3.341   1.00 166.18 ? 121  ALA A O   1 
ATOM   371  C CB  . ALA A 1 101 ? -16.422 10.282  0.992   1.00 180.63 ? 121  ALA A CB  1 
ATOM   372  N N   . GLY A 1 102 ? -17.880 12.973  1.166   1.00 148.83 ? 122  GLY A N   1 
ATOM   373  C CA  . GLY A 1 102 ? -17.874 14.403  1.442   1.00 170.30 ? 122  GLY A CA  1 
ATOM   374  C C   . GLY A 1 102 ? -18.977 14.809  2.400   1.00 161.88 ? 122  GLY A C   1 
ATOM   375  O O   . GLY A 1 102 ? -18.749 15.557  3.356   1.00 133.69 ? 122  GLY A O   1 
ATOM   376  N N   . LEU A 1 103 ? -20.189 14.306  2.163   1.00 164.72 ? 123  LEU A N   1 
ATOM   377  C CA  . LEU A 1 103 ? -21.318 14.643  3.022   1.00 160.03 ? 123  LEU A CA  1 
ATOM   378  C C   . LEU A 1 103 ? -21.094 14.150  4.442   1.00 185.45 ? 123  LEU A C   1 
ATOM   379  O O   . LEU A 1 103 ? -21.380 14.864  5.409   1.00 173.96 ? 123  LEU A O   1 
ATOM   380  C CB  . LEU A 1 103 ? -22.600 14.033  2.460   1.00 184.42 ? 123  LEU A CB  1 
ATOM   381  C CG  . LEU A 1 103 ? -22.985 14.410  1.030   1.00 170.47 ? 123  LEU A CG  1 
ATOM   382  C CD1 . LEU A 1 103 ? -24.179 13.577  0.575   1.00 168.51 ? 123  LEU A CD1 1 
ATOM   383  C CD2 . LEU A 1 103 ? -23.276 15.894  0.921   1.00 171.72 ? 123  LEU A CD2 1 
ATOM   384  N N   . GLY A 1 104 ? -20.600 12.922  4.587   1.00 165.97 ? 124  GLY A N   1 
ATOM   385  C CA  . GLY A 1 104 ? -20.399 12.364  5.906   1.00 174.74 ? 124  GLY A CA  1 
ATOM   386  C C   . GLY A 1 104 ? -19.371 13.132  6.705   1.00 184.47 ? 124  GLY A C   1 
ATOM   387  O O   . GLY A 1 104 ? -19.568 13.392  7.890   1.00 183.88 ? 124  GLY A O   1 
ATOM   388  N N   . LEU A 1 105 ? -18.260 13.514  6.072   1.00 175.61 ? 125  LEU A N   1 
ATOM   389  C CA  . LEU A 1 105 ? -17.265 14.275  6.822   1.00 170.91 ? 125  LEU A CA  1 
ATOM   390  C C   . LEU A 1 105 ? -17.747 15.692  7.111   1.00 141.31 ? 125  LEU A C   1 
ATOM   391  O O   . LEU A 1 105 ? -17.430 16.251  8.169   1.00 148.87 ? 125  LEU A O   1 
ATOM   392  C CB  . LEU A 1 105 ? -15.935 14.295  6.077   1.00 157.13 ? 125  LEU A CB  1 
ATOM   393  C CG  . LEU A 1 105 ? -15.845 15.193  4.849   1.00 167.28 ? 125  LEU A CG  1 
ATOM   394  C CD1 . LEU A 1 105 ? -15.590 16.643  5.252   1.00 174.82 ? 125  LEU A CD1 1 
ATOM   395  C CD2 . LEU A 1 105 ? -14.759 14.671  3.920   1.00 173.03 ? 125  LEU A CD2 1 
ATOM   396  N N   . ILE A 1 106 ? -18.516 16.292  6.198   1.00 159.78 ? 126  ILE A N   1 
ATOM   397  C CA  . ILE A 1 106 ? -19.101 17.595  6.491   1.00 153.90 ? 126  ILE A CA  1 
ATOM   398  C C   . ILE A 1 106 ? -20.005 17.497  7.708   1.00 171.13 ? 126  ILE A C   1 
ATOM   399  O O   . ILE A 1 106 ? -19.956 18.340  8.608   1.00 182.15 ? 126  ILE A O   1 
ATOM   400  C CB  . ILE A 1 106 ? -19.881 18.124  5.280   1.00 186.24 ? 126  ILE A CB  1 
ATOM   401  C CG1 . ILE A 1 106 ? -18.944 18.393  4.116   1.00 159.53 ? 126  ILE A CG1 1 
ATOM   402  C CG2 . ILE A 1 106 ? -20.633 19.389  5.655   1.00 178.20 ? 126  ILE A CG2 1 
ATOM   403  C CD1 . ILE A 1 106 ? -19.687 18.500  2.830   1.00 182.34 ? 126  ILE A CD1 1 
ATOM   404  N N   . LEU A 1 107 ? -20.861 16.475  7.738   1.00 144.80 ? 127  LEU A N   1 
ATOM   405  C CA  . LEU A 1 107 ? -21.746 16.276  8.880   1.00 154.26 ? 127  LEU A CA  1 
ATOM   406  C C   . LEU A 1 107 ? -20.948 15.983  10.141  1.00 196.35 ? 127  LEU A C   1 
ATOM   407  O O   . LEU A 1 107 ? -21.313 16.426  11.235  1.00 194.30 ? 127  LEU A O   1 
ATOM   408  C CB  . LEU A 1 107 ? -22.724 15.138  8.591   1.00 164.76 ? 127  LEU A CB  1 
ATOM   409  C CG  . LEU A 1 107 ? -23.793 15.453  7.544   1.00 195.65 ? 127  LEU A CG  1 
ATOM   410  C CD1 . LEU A 1 107 ? -24.274 14.185  6.860   1.00 220.93 ? 127  LEU A CD1 1 
ATOM   411  C CD2 . LEU A 1 107 ? -24.959 16.185  8.190   1.00 178.63 ? 127  LEU A CD2 1 
ATOM   412  N N   . HIS A 1 108 ? -19.858 15.231  10.010  1.00 178.31 ? 128  HIS A N   1 
ATOM   413  C CA  . HIS A 1 108 ? -19.052 14.915  11.178  1.00 200.14 ? 128  HIS A CA  1 
ATOM   414  C C   . HIS A 1 108 ? -18.408 16.163  11.755  1.00 160.07 ? 128  HIS A C   1 
ATOM   415  O O   . HIS A 1 108 ? -18.241 16.264  12.970  1.00 164.53 ? 128  HIS A O   1 
ATOM   416  C CB  . HIS A 1 108 ? -17.974 13.895  10.842  1.00 197.03 ? 128  HIS A CB  1 
ATOM   417  C CG  . HIS A 1 108 ? -17.032 13.652  11.977  1.00 195.49 ? 128  HIS A CG  1 
ATOM   418  N ND1 . HIS A 1 108 ? -17.376 12.895  13.076  1.00 189.64 ? 128  HIS A ND1 1 
ATOM   419  C CD2 . HIS A 1 108 ? -15.778 14.106  12.210  1.00 206.27 ? 128  HIS A CD2 1 
ATOM   420  C CE1 . HIS A 1 108 ? -16.365 12.873  13.926  1.00 193.06 ? 128  HIS A CE1 1 
ATOM   421  N NE2 . HIS A 1 108 ? -15.384 13.600  13.424  1.00 213.92 ? 128  HIS A NE2 1 
ATOM   422  N N   . PHE A 1 109 ? -18.006 17.109  10.907  1.00 194.74 ? 129  PHE A N   1 
ATOM   423  C CA  . PHE A 1 109 ? -17.550 18.388  11.440  1.00 196.62 ? 129  PHE A CA  1 
ATOM   424  C C   . PHE A 1 109 ? -18.711 19.172  12.038  1.00 197.06 ? 129  PHE A C   1 
ATOM   425  O O   . PHE A 1 109 ? -18.614 19.697  13.154  1.00 217.09 ? 129  PHE A O   1 
ATOM   426  C CB  . PHE A 1 109 ? -16.878 19.235  10.367  1.00 192.66 ? 129  PHE A CB  1 
ATOM   427  C CG  . PHE A 1 109 ? -16.876 20.700  10.704  1.00 219.13 ? 129  PHE A CG  1 
ATOM   428  C CD1 . PHE A 1 109 ? -15.970 21.205  11.618  1.00 215.35 ? 129  PHE A CD1 1 
ATOM   429  C CD2 . PHE A 1 109 ? -17.810 21.562  10.152  1.00 227.87 ? 129  PHE A CD2 1 
ATOM   430  C CE1 . PHE A 1 109 ? -15.969 22.545  11.956  1.00 211.53 ? 129  PHE A CE1 1 
ATOM   431  C CE2 . PHE A 1 109 ? -17.814 22.907  10.486  1.00 221.40 ? 129  PHE A CE2 1 
ATOM   432  C CZ  . PHE A 1 109 ? -16.891 23.397  11.391  1.00 218.81 ? 129  PHE A CZ  1 
ATOM   433  N N   . VAL A 1 110 ? -19.821 19.257  11.301  1.00 221.53 ? 130  VAL A N   1 
ATOM   434  C CA  . VAL A 1 110 ? -20.953 20.079  11.717  1.00 208.69 ? 130  VAL A CA  1 
ATOM   435  C C   . VAL A 1 110 ? -21.381 19.691  13.119  1.00 196.40 ? 130  VAL A C   1 
ATOM   436  O O   . VAL A 1 110 ? -21.607 20.541  13.988  1.00 178.02 ? 130  VAL A O   1 
ATOM   437  C CB  . VAL A 1 110 ? -22.117 19.917  10.722  1.00 223.56 ? 130  VAL A CB  1 
ATOM   438  C CG1 . VAL A 1 110 ? -23.430 20.378  11.348  1.00 195.46 ? 130  VAL A CG1 1 
ATOM   439  C CG2 . VAL A 1 110 ? -21.828 20.668  9.428   1.00 200.80 ? 130  VAL A CG2 1 
ATOM   440  N N   . PHE A 1 111 ? -21.512 18.393  13.349  1.00 181.54 ? 131  PHE A N   1 
ATOM   441  C CA  . PHE A 1 111 ? -21.873 17.895  14.663  1.00 200.19 ? 131  PHE A CA  1 
ATOM   442  C C   . PHE A 1 111 ? -20.676 17.945  15.607  1.00 205.23 ? 131  PHE A C   1 
ATOM   443  O O   . PHE A 1 111 ? -20.800 18.423  16.740  1.00 212.37 ? 131  PHE A O   1 
ATOM   444  C CB  . PHE A 1 111 ? -22.454 16.487  14.504  1.00 207.37 ? 131  PHE A CB  1 
ATOM   445  C CG  . PHE A 1 111 ? -23.780 16.469  13.772  1.00 201.98 ? 131  PHE A CG  1 
ATOM   446  C CD1 . PHE A 1 111 ? -23.890 16.971  12.483  1.00 192.28 ? 131  PHE A CD1 1 
ATOM   447  C CD2 . PHE A 1 111 ? -24.912 15.963  14.376  1.00 200.71 ? 131  PHE A CD2 1 
ATOM   448  C CE1 . PHE A 1 111 ? -25.101 16.969  11.819  1.00 195.23 ? 131  PHE A CE1 1 
ATOM   449  C CE2 . PHE A 1 111 ? -26.128 15.968  13.717  1.00 205.18 ? 131  PHE A CE2 1 
ATOM   450  C CZ  . PHE A 1 111 ? -26.219 16.462  12.436  1.00 204.90 ? 131  PHE A CZ  1 
ATOM   451  N N   . GLN A 1 112 ? -19.496 17.545  15.132  1.00 235.73 ? 132  GLN A N   1 
ATOM   452  C CA  . GLN A 1 112 ? -18.279 17.514  15.936  1.00 208.32 ? 132  GLN A CA  1 
ATOM   453  C C   . GLN A 1 112 ? -18.181 18.745  16.824  1.00 198.22 ? 132  GLN A C   1 
ATOM   454  O O   . GLN A 1 112 ? -17.816 18.641  17.999  1.00 220.26 ? 132  GLN A O   1 
ATOM   455  C CB  . GLN A 1 112 ? -17.047 17.416  15.032  1.00 210.44 ? 132  GLN A CB  1 
ATOM   456  N N   . TYR A 1 113 ? -18.494 19.913  16.271  1.00 208.96 ? 133  TYR A N   1 
ATOM   457  C CA  . TYR A 1 113 ? -18.661 21.134  17.048  1.00 194.21 ? 133  TYR A CA  1 
ATOM   458  C C   . TYR A 1 113 ? -20.131 21.534  16.961  1.00 184.67 ? 133  TYR A C   1 
ATOM   459  O O   . TYR A 1 113 ? -20.630 21.831  15.871  1.00 221.63 ? 133  TYR A O   1 
ATOM   460  C CB  . TYR A 1 113 ? -17.755 22.259  16.538  1.00 213.22 ? 133  TYR A CB  1 
ATOM   461  C CG  . TYR A 1 113 ? -16.323 21.856  16.207  1.00 199.38 ? 133  TYR A CG  1 
ATOM   462  C CD1 . TYR A 1 113 ? -15.738 20.723  16.761  1.00 224.00 ? 133  TYR A CD1 1 
ATOM   463  C CD2 . TYR A 1 113 ? -15.555 22.623  15.339  1.00 223.17 ? 133  TYR A CD2 1 
ATOM   464  C CE1 . TYR A 1 113 ? -14.437 20.362  16.451  1.00 239.76 ? 133  TYR A CE1 1 
ATOM   465  C CE2 . TYR A 1 113 ? -14.254 22.271  15.027  1.00 197.38 ? 133  TYR A CE2 1 
ATOM   466  C CZ  . TYR A 1 113 ? -13.700 21.142  15.585  1.00 187.54 ? 133  TYR A CZ  1 
ATOM   467  O OH  . TYR A 1 113 ? -12.405 20.793  15.271  1.00 191.91 ? 133  TYR A OH  1 
ATOM   468  N N   . LEU A 1 114 ? -20.811 21.554  18.110  1.00 194.16 ? 134  LEU A N   1 
ATOM   469  C CA  . LEU A 1 114 ? -22.242 21.841  18.191  1.00 183.45 ? 134  LEU A CA  1 
ATOM   470  C C   . LEU A 1 114 ? -23.127 20.656  17.807  1.00 186.63 ? 134  LEU A C   1 
ATOM   471  O O   . LEU A 1 114 ? -24.259 20.853  17.352  1.00 174.29 ? 134  LEU A O   1 
ATOM   472  C CB  . LEU A 1 114 ? -22.595 23.043  17.306  1.00 182.86 ? 134  LEU A CB  1 
ATOM   473  N N   . VAL A 1 115 ? -22.637 19.430  17.982  1.00 205.69 ? 135  VAL A N   1 
ATOM   474  C CA  . VAL A 1 115 ? -23.448 18.234  17.747  1.00 221.37 ? 135  VAL A CA  1 
ATOM   475  C C   . VAL A 1 115 ? -24.569 18.143  18.776  1.00 222.96 ? 135  VAL A C   1 
ATOM   476  O O   . VAL A 1 115 ? -24.382 18.549  19.932  1.00 213.35 ? 135  VAL A O   1 
ATOM   477  C CB  . VAL A 1 115 ? -22.606 16.948  17.808  1.00 233.50 ? 135  VAL A CB  1 
ATOM   478  N N   . PRO A 1 116 ? -25.741 17.614  18.409  1.00 224.90 ? 136  PRO A N   1 
ATOM   479  C CA  . PRO A 1 116 ? -26.740 17.258  19.425  1.00 220.18 ? 136  PRO A CA  1 
ATOM   480  C C   . PRO A 1 116 ? -26.351 16.044  20.260  1.00 226.69 ? 136  PRO A C   1 
ATOM   481  O O   . PRO A 1 116 ? -26.479 16.081  21.488  1.00 229.20 ? 136  PRO A O   1 
ATOM   482  C CB  . PRO A 1 116 ? -28.001 16.979  18.592  1.00 219.60 ? 136  PRO A CB  1 
ATOM   483  C CG  . PRO A 1 116 ? -27.492 16.645  17.229  1.00 230.75 ? 136  PRO A CG  1 
ATOM   484  C CD  . PRO A 1 116 ? -26.291 17.517  17.046  1.00 208.58 ? 136  PRO A CD  1 
ATOM   485  N N   . SER A 1 117 ? -25.873 14.970  19.625  1.00 226.49 ? 137  SER A N   1 
ATOM   486  C CA  . SER A 1 117 ? -25.634 13.719  20.336  1.00 217.38 ? 137  SER A CA  1 
ATOM   487  C C   . SER A 1 117 ? -24.499 12.937  19.686  1.00 218.90 ? 137  SER A C   1 
ATOM   488  O O   . SER A 1 117 ? -24.214 13.087  18.495  1.00 222.69 ? 137  SER A O   1 
ATOM   489  C CB  . SER A 1 117 ? -26.902 12.854  20.374  1.00 214.73 ? 137  SER A CB  1 
ATOM   490  O OG  . SER A 1 117 ? -26.611 11.538  20.814  1.00 209.77 ? 137  SER A OG  1 
ATOM   491  N N   . GLU A 1 118 ? -23.856 12.086  20.496  1.00 235.77 ? 138  GLU A N   1 
ATOM   492  C CA  . GLU A 1 118 ? -22.831 11.185  19.973  1.00 204.91 ? 138  GLU A CA  1 
ATOM   493  C C   . GLU A 1 118 ? -23.435 10.175  19.007  1.00 199.69 ? 138  GLU A C   1 
ATOM   494  O O   . GLU A 1 118 ? -22.840 9.880   17.964  1.00 197.49 ? 138  GLU A O   1 
ATOM   495  C CB  . GLU A 1 118 ? -22.122 10.459  21.118  1.00 207.02 ? 138  GLU A CB  1 
ATOM   496  C CG  . GLU A 1 118 ? -20.692 10.004  20.801  1.00 188.32 ? 138  GLU A CG  1 
ATOM   497  C CD  . GLU A 1 118 ? -20.592 9.153   19.546  1.00 224.42 ? 138  GLU A CD  1 
ATOM   498  O OE1 . GLU A 1 118 ? -21.370 8.184   19.415  1.00 223.88 ? 138  GLU A OE1 1 
ATOM   499  O OE2 . GLU A 1 118 ? -19.738 9.460   18.686  1.00 206.45 ? 138  GLU A OE2 1 
ATOM   500  N N   . THR A 1 119 ? -24.606 9.624   19.347  1.00 208.06 ? 139  THR A N   1 
ATOM   501  C CA  . THR A 1 119 ? -25.311 8.714   18.448  1.00 197.80 ? 139  THR A CA  1 
ATOM   502  C C   . THR A 1 119 ? -25.183 9.184   17.005  1.00 222.18 ? 139  THR A C   1 
ATOM   503  O O   . THR A 1 119 ? -24.868 8.402   16.098  1.00 198.66 ? 139  THR A O   1 
ATOM   504  C CB  . THR A 1 119 ? -26.787 8.625   18.858  1.00 190.36 ? 139  THR A CB  1 
ATOM   505  O OG1 . THR A 1 119 ? -26.887 8.146   20.205  1.00 208.30 ? 139  THR A OG1 1 
ATOM   506  C CG2 . THR A 1 119 ? -27.558 7.693   17.938  1.00 176.79 ? 139  THR A CG2 1 
ATOM   507  N N   . VAL A 1 120 ? -25.383 10.484  16.790  1.00 195.17 ? 140  VAL A N   1 
ATOM   508  C CA  . VAL A 1 120 ? -25.324 11.030  15.440  1.00 191.56 ? 140  VAL A CA  1 
ATOM   509  C C   . VAL A 1 120 ? -23.918 10.893  14.865  1.00 191.77 ? 140  VAL A C   1 
ATOM   510  O O   . VAL A 1 120 ? -23.747 10.594  13.679  1.00 179.46 ? 140  VAL A O   1 
ATOM   511  C CB  . VAL A 1 120 ? -25.794 12.497  15.430  1.00 222.04 ? 140  VAL A CB  1 
ATOM   512  C CG1 . VAL A 1 120 ? -26.151 12.902  14.013  1.00 209.19 ? 140  VAL A CG1 1 
ATOM   513  C CG2 . VAL A 1 120 ? -26.974 12.712  16.383  1.00 224.40 ? 140  VAL A CG2 1 
ATOM   514  N N   . SER A 1 121 ? -22.890 11.134  15.684  1.00 217.32 ? 141  SER A N   1 
ATOM   515  C CA  . SER A 1 121 ? -21.518 10.997  15.199  1.00 180.97 ? 141  SER A CA  1 
ATOM   516  C C   . SER A 1 121 ? -21.196 9.547   14.853  1.00 186.17 ? 141  SER A C   1 
ATOM   517  O O   . SER A 1 121 ? -20.442 9.278   13.910  1.00 188.09 ? 141  SER A O   1 
ATOM   518  C CB  . SER A 1 121 ? -20.533 11.527  16.238  1.00 210.40 ? 141  SER A CB  1 
ATOM   519  O OG  . SER A 1 121 ? -19.196 11.280  15.836  1.00 206.98 ? 141  SER A OG  1 
ATOM   520  N N   . LEU A 1 122 ? -21.748 8.601   15.611  1.00 210.21 ? 142  LEU A N   1 
ATOM   521  C CA  . LEU A 1 122 ? -21.597 7.194   15.255  1.00 174.34 ? 142  LEU A CA  1 
ATOM   522  C C   . LEU A 1 122 ? -22.252 6.907   13.907  1.00 168.15 ? 142  LEU A C   1 
ATOM   523  O O   . LEU A 1 122 ? -21.703 6.173   13.073  1.00 174.51 ? 142  LEU A O   1 
ATOM   524  C CB  . LEU A 1 122 ? -22.192 6.323   16.360  1.00 201.98 ? 142  LEU A CB  1 
ATOM   525  C CG  . LEU A 1 122 ? -22.157 4.814   16.143  1.00 178.82 ? 142  LEU A CG  1 
ATOM   526  C CD1 . LEU A 1 122 ? -21.952 4.094   17.463  1.00 174.56 ? 142  LEU A CD1 1 
ATOM   527  C CD2 . LEU A 1 122 ? -23.443 4.371   15.507  1.00 187.23 ? 142  LEU A CD2 1 
ATOM   528  N N   . LEU A 1 123 ? -23.423 7.494   13.667  1.00 180.82 ? 143  LEU A N   1 
ATOM   529  C CA  . LEU A 1 123 ? -24.055 7.339   12.359  1.00 210.81 ? 143  LEU A CA  1 
ATOM   530  C C   . LEU A 1 123 ? -23.206 7.961   11.251  1.00 199.90 ? 143  LEU A C   1 
ATOM   531  O O   . LEU A 1 123 ? -23.113 7.415   10.147  1.00 166.06 ? 143  LEU A O   1 
ATOM   532  C CB  . LEU A 1 123 ? -25.457 7.948   12.376  1.00 204.72 ? 143  LEU A CB  1 
ATOM   533  C CG  . LEU A 1 123 ? -26.550 7.045   12.961  1.00 197.57 ? 143  LEU A CG  1 
ATOM   534  C CD1 . LEU A 1 123 ? -26.766 7.291   14.447  1.00 200.81 ? 143  LEU A CD1 1 
ATOM   535  C CD2 . LEU A 1 123 ? -27.858 7.214   12.202  1.00 201.44 ? 143  LEU A CD2 1 
ATOM   536  N N   . THR A 1 124 ? -22.580 9.108   11.519  1.00 181.28 ? 144  THR A N   1 
ATOM   537  C CA  . THR A 1 124 ? -21.763 9.741   10.484  1.00 145.85 ? 144  THR A CA  1 
ATOM   538  C C   . THR A 1 124 ? -20.493 8.939   10.201  1.00 179.21 ? 144  THR A C   1 
ATOM   539  O O   . THR A 1 124 ? -20.018 8.913   9.058   1.00 203.13 ? 144  THR A O   1 
ATOM   540  C CB  . THR A 1 124 ? -21.405 11.180  10.868  1.00 152.63 ? 144  THR A CB  1 
ATOM   541  O OG1 . THR A 1 124 ? -20.636 11.188  12.076  1.00 173.14 ? 144  THR A OG1 1 
ATOM   542  C CG2 . THR A 1 124 ? -22.664 12.028  11.050  1.00 191.38 ? 144  THR A CG2 1 
ATOM   543  N N   . VAL A 1 125 ? -19.916 8.289   11.215  1.00 173.12 ? 145  VAL A N   1 
ATOM   544  C CA  . VAL A 1 125 ? -18.809 7.384   10.915  1.00 166.12 ? 145  VAL A CA  1 
ATOM   545  C C   . VAL A 1 125 ? -19.323 6.201   10.108  1.00 165.11 ? 145  VAL A C   1 
ATOM   546  O O   . VAL A 1 125 ? -18.611 5.674   9.248   1.00 153.71 ? 145  VAL A O   1 
ATOM   547  C CB  . VAL A 1 125 ? -18.060 6.918   12.180  1.00 189.73 ? 145  VAL A CB  1 
ATOM   548  C CG1 . VAL A 1 125 ? -17.505 8.115   12.942  1.00 164.06 ? 145  VAL A CG1 1 
ATOM   549  C CG2 . VAL A 1 125 ? -18.939 6.068   13.070  1.00 171.13 ? 145  VAL A CG2 1 
ATOM   550  N N   . GLY A 1 126 ? -20.553 5.754   10.374  1.00 154.25 ? 146  GLY A N   1 
ATOM   551  C CA  . GLY A 1 126 ? -21.181 4.815   9.461   1.00 173.66 ? 146  GLY A CA  1 
ATOM   552  C C   . GLY A 1 126 ? -21.219 5.362   8.047   1.00 169.32 ? 146  GLY A C   1 
ATOM   553  O O   . GLY A 1 126 ? -21.019 4.631   7.077   1.00 165.02 ? 146  GLY A O   1 
ATOM   554  N N   . PHE A 1 127 ? -21.465 6.664   7.924   1.00 176.24 ? 147  PHE A N   1 
ATOM   555  C CA  . PHE A 1 127 ? -21.450 7.330   6.625   1.00 143.07 ? 147  PHE A CA  1 
ATOM   556  C C   . PHE A 1 127 ? -20.093 7.189   5.944   1.00 155.16 ? 147  PHE A C   1 
ATOM   557  O O   . PHE A 1 127 ? -20.007 6.798   4.776   1.00 161.01 ? 147  PHE A O   1 
ATOM   558  C CB  . PHE A 1 127 ? -21.791 8.808   6.814   1.00 179.96 ? 147  PHE A CB  1 
ATOM   559  C CG  . PHE A 1 127 ? -22.842 9.317   5.885   1.00 160.17 ? 147  PHE A CG  1 
ATOM   560  C CD1 . PHE A 1 127 ? -24.170 8.974   6.070   1.00 176.53 ? 147  PHE A CD1 1 
ATOM   561  C CD2 . PHE A 1 127 ? -22.509 10.161  4.841   1.00 169.83 ? 147  PHE A CD2 1 
ATOM   562  C CE1 . PHE A 1 127 ? -25.146 9.449   5.220   1.00 205.79 ? 147  PHE A CE1 1 
ATOM   563  C CE2 . PHE A 1 127 ? -23.478 10.642  3.987   1.00 176.63 ? 147  PHE A CE2 1 
ATOM   564  C CZ  . PHE A 1 127 ? -24.800 10.286  4.177   1.00 206.81 ? 147  PHE A CZ  1 
ATOM   565  N N   . LEU A 1 128 ? -19.021 7.543   6.656   1.00 143.45 ? 148  LEU A N   1 
ATOM   566  C CA  . LEU A 1 128 ? -17.682 7.470   6.067   1.00 160.24 ? 148  LEU A CA  1 
ATOM   567  C C   . LEU A 1 128 ? -17.313 6.030   5.724   1.00 159.80 ? 148  LEU A C   1 
ATOM   568  O O   . LEU A 1 128 ? -16.696 5.760   4.682   1.00 143.99 ? 148  LEU A O   1 
ATOM   569  C CB  . LEU A 1 128 ? -16.638 8.061   7.016   1.00 165.02 ? 148  LEU A CB  1 
ATOM   570  C CG  . LEU A 1 128 ? -16.517 9.583   7.132   1.00 160.93 ? 148  LEU A CG  1 
ATOM   571  C CD1 . LEU A 1 128 ? -16.434 10.244  5.762   1.00 162.56 ? 148  LEU A CD1 1 
ATOM   572  C CD2 . LEU A 1 128 ? -17.667 10.163  7.940   1.00 169.98 ? 148  LEU A CD2 1 
ATOM   573  N N   . VAL A 1 129 ? -17.669 5.097   6.606   1.00 166.67 ? 149  VAL A N   1 
ATOM   574  C CA  . VAL A 1 129 ? -17.444 3.680   6.346   1.00 159.95 ? 149  VAL A CA  1 
ATOM   575  C C   . VAL A 1 129 ? -18.141 3.271   5.058   1.00 147.62 ? 149  VAL A C   1 
ATOM   576  O O   . VAL A 1 129 ? -17.564 2.591   4.199   1.00 154.08 ? 149  VAL A O   1 
ATOM   577  C CB  . VAL A 1 129 ? -17.941 2.845   7.541   1.00 165.17 ? 149  VAL A CB  1 
ATOM   578  C CG1 . VAL A 1 129 ? -17.947 1.367   7.196   1.00 146.80 ? 149  VAL A CG1 1 
ATOM   579  C CG2 . VAL A 1 129 ? -17.093 3.119   8.781   1.00 146.90 ? 149  VAL A CG2 1 
ATOM   580  N N   . ALA A 1 130 ? -19.402 3.683   4.911   1.00 147.59 ? 150  ALA A N   1 
ATOM   581  C CA  . ALA A 1 130 ? -20.168 3.343   3.723   1.00 145.67 ? 150  ALA A CA  1 
ATOM   582  C C   . ALA A 1 130 ? -19.543 3.948   2.476   1.00 150.37 ? 150  ALA A C   1 
ATOM   583  O O   . ALA A 1 130 ? -19.489 3.302   1.427   1.00 159.80 ? 150  ALA A O   1 
ATOM   584  C CB  . ALA A 1 130 ? -21.611 3.816   3.891   1.00 154.85 ? 150  ALA A CB  1 
ATOM   585  N N   . SER A 1 131 ? -19.073 5.192   2.566   1.00 137.09 ? 151  SER A N   1 
ATOM   586  C CA  . SER A 1 131 ? -18.443 5.818   1.408   1.00 116.94 ? 151  SER A CA  1 
ATOM   587  C C   . SER A 1 131 ? -17.210 5.033   0.976   1.00 135.66 ? 151  SER A C   1 
ATOM   588  O O   . SER A 1 131 ? -17.036 4.732   -0.210  1.00 136.63 ? 151  SER A O   1 
ATOM   589  C CB  . SER A 1 131 ? -18.076 7.268   1.723   1.00 116.19 ? 151  SER A CB  1 
ATOM   590  O OG  . SER A 1 131 ? -16.979 7.335   2.615   1.00 180.64 ? 151  SER A OG  1 
ATOM   591  N N   . PHE A 1 132 ? -16.350 4.671   1.933   1.00 155.42 ? 152  PHE A N   1 
ATOM   592  C CA  . PHE A 1 132 ? -15.156 3.901   1.588   1.00 150.90 ? 152  PHE A CA  1 
ATOM   593  C C   . PHE A 1 132 ? -15.529 2.563   0.957   1.00 141.81 ? 152  PHE A C   1 
ATOM   594  O O   . PHE A 1 132 ? -14.985 2.175   -0.090  1.00 125.10 ? 152  PHE A O   1 
ATOM   595  C CB  . PHE A 1 132 ? -14.291 3.680   2.831   1.00 156.05 ? 152  PHE A CB  1 
ATOM   596  C CG  . PHE A 1 132 ? -13.168 2.702   2.619   1.00 136.27 ? 152  PHE A CG  1 
ATOM   597  C CD1 . PHE A 1 132 ? -11.983 3.106   2.027   1.00 144.88 ? 152  PHE A CD1 1 
ATOM   598  C CD2 . PHE A 1 132 ? -13.300 1.376   3.005   1.00 121.61 ? 152  PHE A CD2 1 
ATOM   599  C CE1 . PHE A 1 132 ? -10.953 2.209   1.826   1.00 142.38 ? 152  PHE A CE1 1 
ATOM   600  C CE2 . PHE A 1 132 ? -12.272 0.474   2.806   1.00 107.41 ? 152  PHE A CE2 1 
ATOM   601  C CZ  . PHE A 1 132 ? -11.099 0.891   2.217   1.00 145.70 ? 152  PHE A CZ  1 
ATOM   602  N N   . ALA A 1 133 ? -16.454 1.836   1.587   1.00 123.99 ? 153  ALA A N   1 
ATOM   603  C CA  . ALA A 1 133 ? -16.809 0.513   1.090   1.00 128.39 ? 153  ALA A CA  1 
ATOM   604  C C   . ALA A 1 133 ? -17.436 0.594   -0.293  1.00 137.04 ? 153  ALA A C   1 
ATOM   605  O O   . ALA A 1 133 ? -17.113 -0.207  -1.177  1.00 149.59 ? 153  ALA A O   1 
ATOM   606  C CB  . ALA A 1 133 ? -17.759 -0.174  2.068   1.00 143.55 ? 153  ALA A CB  1 
ATOM   607  N N   . ALA A 1 134 ? -18.343 1.550   -0.498  1.00 160.65 ? 154  ALA A N   1 
ATOM   608  C CA  . ALA A 1 134 ? -18.970 1.708   -1.802  1.00 163.92 ? 154  ALA A CA  1 
ATOM   609  C C   . ALA A 1 134 ? -17.940 2.078   -2.854  1.00 156.84 ? 154  ALA A C   1 
ATOM   610  O O   . ALA A 1 134 ? -17.977 1.562   -3.975  1.00 149.57 ? 154  ALA A O   1 
ATOM   611  C CB  . ALA A 1 134 ? -20.069 2.767   -1.733  1.00 167.33 ? 154  ALA A CB  1 
ATOM   612  N N   . SER A 1 135 ? -17.009 2.970   -2.512  1.00 149.93 ? 155  SER A N   1 
ATOM   613  C CA  . SER A 1 135 ? -15.962 3.330   -3.458  1.00 162.64 ? 155  SER A CA  1 
ATOM   614  C C   . SER A 1 135 ? -15.183 2.097   -3.893  1.00 157.53 ? 155  SER A C   1 
ATOM   615  O O   . SER A 1 135 ? -15.049 1.824   -5.091  1.00 128.08 ? 155  SER A O   1 
ATOM   616  C CB  . SER A 1 135 ? -15.030 4.369   -2.833  1.00 150.08 ? 155  SER A CB  1 
ATOM   617  O OG  . SER A 1 135 ? -14.456 3.885   -1.631  1.00 139.66 ? 155  SER A OG  1 
ATOM   618  N N   . VAL A 1 136 ? -14.684 1.321   -2.929  1.00 148.71 ? 156  VAL A N   1 
ATOM   619  C CA  . VAL A 1 136 ? -13.855 0.169   -3.281  1.00 142.26 ? 156  VAL A CA  1 
ATOM   620  C C   . VAL A 1 136 ? -14.669 -0.850  -4.080  1.00 134.60 ? 156  VAL A C   1 
ATOM   621  O O   . VAL A 1 136 ? -14.202 -1.393  -5.098  1.00 154.16 ? 156  VAL A O   1 
ATOM   622  C CB  . VAL A 1 136 ? -13.225 -0.437  -2.008  1.00 141.40 ? 156  VAL A CB  1 
ATOM   623  C CG1 . VAL A 1 136 ? -14.284 -0.961  -1.057  1.00 129.04 ? 156  VAL A CG1 1 
ATOM   624  C CG2 . VAL A 1 136 ? -12.221 -1.528  -2.356  1.00 139.77 ? 156  VAL A CG2 1 
ATOM   625  N N   . SER A 1 137 ? -15.907 -1.104  -3.654  1.00 139.45 ? 157  SER A N   1 
ATOM   626  C CA  . SER A 1 137 ? -16.737 -2.092  -4.331  1.00 150.37 ? 157  SER A CA  1 
ATOM   627  C C   . SER A 1 137 ? -17.025 -1.676  -5.767  1.00 167.93 ? 157  SER A C   1 
ATOM   628  O O   . SER A 1 137 ? -16.852 -2.465  -6.703  1.00 172.17 ? 157  SER A O   1 
ATOM   629  C CB  . SER A 1 137 ? -18.038 -2.283  -3.551  1.00 139.37 ? 157  SER A CB  1 
ATOM   630  O OG  . SER A 1 137 ? -18.869 -3.246  -4.171  1.00 178.58 ? 157  SER A OG  1 
ATOM   631  N N   . SER A 1 138 ? -17.458 -0.432  -5.965  1.00 146.96 ? 158  SER A N   1 
ATOM   632  C CA  . SER A 1 138 ? -17.757 0.034   -7.312  1.00 169.06 ? 158  SER A CA  1 
ATOM   633  C C   . SER A 1 138 ? -16.500 0.116   -8.169  1.00 160.62 ? 158  SER A C   1 
ATOM   634  O O   . SER A 1 138 ? -16.581 -0.012  -9.395  1.00 131.67 ? 158  SER A O   1 
ATOM   635  C CB  . SER A 1 138 ? -18.456 1.392   -7.245  1.00 160.40 ? 158  SER A CB  1 
ATOM   636  O OG  . SER A 1 138 ? -17.740 2.297   -6.423  1.00 163.97 ? 158  SER A OG  1 
ATOM   637  N N   . LEU A 1 139 ? -15.333 0.323   -7.557  1.00 160.92 ? 159  LEU A N   1 
ATOM   638  C CA  . LEU A 1 139 ? -14.094 0.305   -8.329  1.00 141.87 ? 159  LEU A CA  1 
ATOM   639  C C   . LEU A 1 139 ? -13.836 -1.086  -8.891  1.00 124.07 ? 159  LEU A C   1 
ATOM   640  O O   . LEU A 1 139 ? -13.532 -1.249  -10.084 1.00 128.60 ? 159  LEU A O   1 
ATOM   641  C CB  . LEU A 1 139 ? -12.931 0.763   -7.449  1.00 144.70 ? 159  LEU A CB  1 
ATOM   642  C CG  . LEU A 1 139 ? -11.635 1.183   -8.143  1.00 151.50 ? 159  LEU A CG  1 
ATOM   643  C CD1 . LEU A 1 139 ? -11.897 2.249   -9.190  1.00 154.66 ? 159  LEU A CD1 1 
ATOM   644  C CD2 . LEU A 1 139 ? -10.630 1.691   -7.115  1.00 157.23 ? 159  LEU A CD2 1 
ATOM   645  N N   . LEU A 1 140 ? -13.970 -2.106  -8.044  1.00 125.26 ? 160  LEU A N   1 
ATOM   646  C CA  . LEU A 1 140 ? -13.917 -3.472  -8.554  1.00 129.33 ? 160  LEU A CA  1 
ATOM   647  C C   . LEU A 1 140 ? -14.976 -3.689  -9.630  1.00 132.24 ? 160  LEU A C   1 
ATOM   648  O O   . LEU A 1 140 ? -14.746 -4.405  -10.617 1.00 147.37 ? 160  LEU A O   1 
ATOM   649  C CB  . LEU A 1 140 ? -14.109 -4.461  -7.409  1.00 145.63 ? 160  LEU A CB  1 
ATOM   650  C CG  . LEU A 1 140 ? -14.089 -5.933  -7.816  1.00 147.22 ? 160  LEU A CG  1 
ATOM   651  C CD1 . LEU A 1 140 ? -12.696 -6.359  -8.261  1.00 161.01 ? 160  LEU A CD1 1 
ATOM   652  C CD2 . LEU A 1 140 ? -14.580 -6.791  -6.664  1.00 186.58 ? 160  LEU A CD2 1 
ATOM   653  N N   . ALA A 1 141 ? -16.148 -3.078  -9.449  1.00 132.16 ? 161  ALA A N   1 
ATOM   654  C CA  . ALA A 1 141 ? -17.228 -3.241  -10.415 1.00 137.99 ? 161  ALA A CA  1 
ATOM   655  C C   . ALA A 1 141 ? -16.836 -2.696  -11.783 1.00 138.02 ? 161  ALA A C   1 
ATOM   656  O O   . ALA A 1 141 ? -17.102 -3.327  -12.810 1.00 107.41 ? 161  ALA A O   1 
ATOM   657  C CB  . ALA A 1 141 ? -18.488 -2.546  -9.904  1.00 143.51 ? 161  ALA A CB  1 
ATOM   658  N N   . ILE A 1 142 ? -16.219 -1.516  -11.818 1.00 129.06 ? 162  ILE A N   1 
ATOM   659  C CA  . ILE A 1 142 ? -15.801 -0.947  -13.095 1.00 114.59 ? 162  ILE A CA  1 
ATOM   660  C C   . ILE A 1 142 ? -14.701 -1.797  -13.711 1.00 114.01 ? 162  ILE A C   1 
ATOM   661  O O   . ILE A 1 142 ? -14.649 -1.981  -14.933 1.00 117.69 ? 162  ILE A O   1 
ATOM   662  C CB  . ILE A 1 142 ? -15.353 0.515   -12.923 1.00 121.43 ? 162  ILE A CB  1 
ATOM   663  C CG1 . ILE A 1 142 ? -16.513 1.357   -12.386 1.00 126.57 ? 162  ILE A CG1 1 
ATOM   664  C CG2 . ILE A 1 142 ? -14.845 1.075   -14.260 1.00 119.54 ? 162  ILE A CG2 1 
ATOM   665  C CD1 . ILE A 1 142 ? -16.138 2.780   -12.044 1.00 152.41 ? 162  ILE A CD1 1 
ATOM   666  N N   . THR A 1 143 ? -13.799 -2.322  -12.880 1.00 115.12 ? 163  THR A N   1 
ATOM   667  C CA  . THR A 1 143 ? -12.788 -3.234  -13.401 1.00 107.41 ? 163  THR A CA  1 
ATOM   668  C C   . THR A 1 143 ? -13.443 -4.394  -14.140 1.00 107.41 ? 163  THR A C   1 
ATOM   669  O O   . THR A 1 143 ? -13.069 -4.721  -15.274 1.00 107.41 ? 163  THR A O   1 
ATOM   670  C CB  . THR A 1 143 ? -11.909 -3.755  -12.264 1.00 111.88 ? 163  THR A CB  1 
ATOM   671  O OG1 . THR A 1 143 ? -11.190 -2.666  -11.673 1.00 130.09 ? 163  THR A OG1 1 
ATOM   672  C CG2 . THR A 1 143 ? -10.923 -4.797  -12.781 1.00 122.41 ? 163  THR A CG2 1 
ATOM   673  N N   . VAL A 1 144 ? -14.437 -5.023  -13.512 1.00 114.00 ? 164  VAL A N   1 
ATOM   674  C CA  . VAL A 1 144 ? -15.060 -6.181  -14.144 1.00 133.16 ? 164  VAL A CA  1 
ATOM   675  C C   . VAL A 1 144 ? -15.893 -5.765  -15.348 1.00 134.03 ? 164  VAL A C   1 
ATOM   676  O O   . VAL A 1 144 ? -15.998 -6.517  -16.320 1.00 144.16 ? 164  VAL A O   1 
ATOM   677  C CB  . VAL A 1 144 ? -15.905 -6.977  -13.133 1.00 135.71 ? 164  VAL A CB  1 
ATOM   678  C CG1 . VAL A 1 144 ? -15.017 -7.542  -12.037 1.00 155.67 ? 164  VAL A CG1 1 
ATOM   679  C CG2 . VAL A 1 144 ? -17.003 -6.115  -12.547 1.00 135.69 ? 164  VAL A CG2 1 
ATOM   680  N N   . ASP A 1 145 ? -16.515 -4.587  -15.307 1.00 119.21 ? 165  ASP A N   1 
ATOM   681  C CA  . ASP A 1 145 ? -17.252 -4.109  -16.472 1.00 126.20 ? 165  ASP A CA  1 
ATOM   682  C C   . ASP A 1 145 ? -16.322 -3.966  -17.664 1.00 128.81 ? 165  ASP A C   1 
ATOM   683  O O   . ASP A 1 145 ? -16.644 -4.396  -18.776 1.00 132.60 ? 165  ASP A O   1 
ATOM   684  C CB  . ASP A 1 145 ? -17.923 -2.773  -16.164 1.00 129.94 ? 165  ASP A CB  1 
ATOM   685  C CG  . ASP A 1 145 ? -18.200 -1.960  -17.412 1.00 126.70 ? 165  ASP A CG  1 
ATOM   686  O OD1 . ASP A 1 145 ? -19.157 -2.295  -18.140 1.00 140.13 ? 165  ASP A OD1 1 
ATOM   687  O OD2 . ASP A 1 145 ? -17.458 -0.988  -17.664 1.00 127.18 ? 165  ASP A OD2 1 
ATOM   688  N N   . ARG A 1 146 ? -15.155 -3.367  -17.443 1.00 131.73 ? 166  ARG A N   1 
ATOM   689  C CA  . ARG A 1 146 ? -14.162 -3.263  -18.503 1.00 116.95 ? 166  ARG A CA  1 
ATOM   690  C C   . ARG A 1 146 ? -13.747 -4.643  -18.995 1.00 110.96 ? 166  ARG A C   1 
ATOM   691  O O   . ARG A 1 146 ? -13.714 -4.905  -20.206 1.00 149.70 ? 166  ARG A O   1 
ATOM   692  C CB  . ARG A 1 146 ? -12.951 -2.493  -17.985 1.00 120.44 ? 166  ARG A CB  1 
ATOM   693  C CG  . ARG A 1 146 ? -12.009 -2.043  -19.064 1.00 138.14 ? 166  ARG A CG  1 
ATOM   694  C CD  . ARG A 1 146 ? -12.533 -0.808  -19.755 1.00 127.03 ? 166  ARG A CD  1 
ATOM   695  N NE  . ARG A 1 146 ? -12.657 0.314   -18.832 1.00 138.50 ? 166  ARG A NE  1 
ATOM   696  C CZ  . ARG A 1 146 ? -12.894 1.564   -19.203 1.00 162.20 ? 166  ARG A CZ  1 
ATOM   697  N NH1 . ARG A 1 146 ? -13.051 1.889   -20.476 1.00 188.40 ? 166  ARG A NH1 1 
ATOM   698  N NH2 . ARG A 1 146 ? -12.967 2.513   -18.275 1.00 143.11 ? 166  ARG A NH2 1 
ATOM   699  N N   . TYR A 1 147 ? -13.428 -5.544  -18.063 1.00 107.41 ? 167  TYR A N   1 
ATOM   700  C CA  . TYR A 1 147 ? -12.954 -6.867  -18.452 1.00 121.66 ? 167  TYR A CA  1 
ATOM   701  C C   . TYR A 1 147 ? -14.003 -7.603  -19.274 1.00 167.96 ? 167  TYR A C   1 
ATOM   702  O O   . TYR A 1 147 ? -13.678 -8.249  -20.276 1.00 155.70 ? 167  TYR A O   1 
ATOM   703  C CB  . TYR A 1 147 ? -12.576 -7.677  -17.210 1.00 142.91 ? 167  TYR A CB  1 
ATOM   704  C CG  . TYR A 1 147 ? -12.311 -9.146  -17.478 1.00 141.73 ? 167  TYR A CG  1 
ATOM   705  C CD1 . TYR A 1 147 ? -11.076 -9.581  -17.944 1.00 146.57 ? 167  TYR A CD1 1 
ATOM   706  C CD2 . TYR A 1 147 ? -13.295 -10.099 -17.256 1.00 155.36 ? 167  TYR A CD2 1 
ATOM   707  C CE1 . TYR A 1 147 ? -10.833 -10.925 -18.185 1.00 154.17 ? 167  TYR A CE1 1 
ATOM   708  C CE2 . TYR A 1 147 ? -13.061 -11.442 -17.494 1.00 138.63 ? 167  TYR A CE2 1 
ATOM   709  C CZ  . TYR A 1 147 ? -11.830 -11.849 -17.958 1.00 141.23 ? 167  TYR A CZ  1 
ATOM   710  O OH  . TYR A 1 147 ? -11.597 -13.186 -18.193 1.00 154.96 ? 167  TYR A OH  1 
ATOM   711  N N   . LEU A 1 148 ? -15.269 -7.516  -18.868 1.00 148.47 ? 168  LEU A N   1 
ATOM   712  C CA  . LEU A 1 148 ? -16.333 -8.181  -19.609 1.00 187.92 ? 168  LEU A CA  1 
ATOM   713  C C   . LEU A 1 148 ? -16.547 -7.530  -20.968 1.00 159.32 ? 168  LEU A C   1 
ATOM   714  O O   . LEU A 1 148 ? -16.686 -8.224  -21.982 1.00 165.54 ? 168  LEU A O   1 
ATOM   715  C CB  . LEU A 1 148 ? -17.625 -8.158  -18.792 1.00 160.03 ? 168  LEU A CB  1 
ATOM   716  N N   . SER A 1 149 ? -16.562 -6.196  -21.014 1.00 163.21 ? 169  SER A N   1 
ATOM   717  C CA  . SER A 1 149 ? -16.792 -5.508  -22.276 1.00 159.33 ? 169  SER A CA  1 
ATOM   718  C C   . SER A 1 149 ? -15.721 -5.853  -23.295 1.00 168.03 ? 169  SER A C   1 
ATOM   719  O O   . SER A 1 149 ? -16.012 -5.942  -24.492 1.00 185.82 ? 169  SER A O   1 
ATOM   720  C CB  . SER A 1 149 ? -16.838 -3.996  -22.050 1.00 164.45 ? 169  SER A CB  1 
ATOM   721  O OG  . SER A 1 149 ? -15.577 -3.501  -21.631 1.00 138.45 ? 169  SER A OG  1 
ATOM   722  N N   . LEU A 1 150 ? -14.483 -6.055  -22.848 1.00 171.91 ? 170  LEU A N   1 
ATOM   723  C CA  . LEU A 1 150 ? -13.398 -6.323  -23.783 1.00 192.58 ? 170  LEU A CA  1 
ATOM   724  C C   . LEU A 1 150 ? -13.183 -7.809  -24.056 1.00 168.69 ? 170  LEU A C   1 
ATOM   725  O O   . LEU A 1 150 ? -12.689 -8.163  -25.133 1.00 192.96 ? 170  LEU A O   1 
ATOM   726  C CB  . LEU A 1 150 ? -12.100 -5.705  -23.257 1.00 156.30 ? 170  LEU A CB  1 
ATOM   727  C CG  . LEU A 1 150 ? -12.180 -4.199  -22.989 1.00 137.57 ? 170  LEU A CG  1 
ATOM   728  C CD1 . LEU A 1 150 ? -10.926 -3.708  -22.282 1.00 137.67 ? 170  LEU A CD1 1 
ATOM   729  C CD2 . LEU A 1 150 ? -12.405 -3.431  -24.283 1.00 150.77 ? 170  LEU A CD2 1 
ATOM   730  N N   . TYR A 1 151 ? -13.551 -8.688  -23.119 1.00 155.09 ? 171  TYR A N   1 
ATOM   731  C CA  . TYR A 1 151 ? -13.241 -10.108 -23.266 1.00 190.89 ? 171  TYR A CA  1 
ATOM   732  C C   . TYR A 1 151 ? -13.902 -10.692 -24.507 1.00 213.15 ? 171  TYR A C   1 
ATOM   733  O O   . TYR A 1 151 ? -13.263 -11.400 -25.296 1.00 157.55 ? 171  TYR A O   1 
ATOM   734  C CB  . TYR A 1 151 ? -13.688 -10.869 -22.016 1.00 153.63 ? 171  TYR A CB  1 
ATOM   735  C CG  . TYR A 1 151 ? -13.407 -12.356 -22.070 1.00 159.68 ? 171  TYR A CG  1 
ATOM   736  C CD1 . TYR A 1 151 ? -14.336 -13.240 -22.604 1.00 198.62 ? 171  TYR A CD1 1 
ATOM   737  C CD2 . TYR A 1 151 ? -12.213 -12.874 -21.587 1.00 164.18 ? 171  TYR A CD2 1 
ATOM   738  C CE1 . TYR A 1 151 ? -14.082 -14.599 -22.658 1.00 181.41 ? 171  TYR A CE1 1 
ATOM   739  C CE2 . TYR A 1 151 ? -11.950 -14.231 -21.635 1.00 185.13 ? 171  TYR A CE2 1 
ATOM   740  C CZ  . TYR A 1 151 ? -12.888 -15.089 -22.172 1.00 185.25 ? 171  TYR A CZ  1 
ATOM   741  O OH  . TYR A 1 151 ? -12.629 -16.440 -22.222 1.00 202.81 ? 171  TYR A OH  1 
ATOM   742  N N   . ASN A 1 152 ? -15.182 -10.410 -24.691 1.00 196.25 ? 172  ASN A N   1 
ATOM   743  C CA  . ASN A 1 152 ? -15.948 -10.912 -25.821 1.00 185.93 ? 172  ASN A CA  1 
ATOM   744  C C   . ASN A 1 152 ? -17.156 -9.998  -25.984 1.00 186.57 ? 172  ASN A C   1 
ATOM   745  O O   . ASN A 1 152 ? -18.264 -10.344 -25.553 1.00 175.67 ? 172  ASN A O   1 
ATOM   746  C CB  . ASN A 1 152 ? -16.366 -12.367 -25.598 1.00 190.67 ? 172  ASN A CB  1 
ATOM   747  C CG  . ASN A 1 152 ? -16.266 -13.206 -26.859 1.00 194.86 ? 172  ASN A CG  1 
ATOM   748  O OD1 . ASN A 1 152 ? -16.207 -12.679 -27.971 1.00 226.53 ? 172  ASN A OD1 1 
ATOM   749  N ND2 . ASN A 1 152 ? -16.250 -14.525 -26.690 1.00 190.27 ? 172  ASN A ND2 1 
ATOM   750  N N   . PRO A 1 153 ? -16.982 -8.822  -26.592 1.00 179.61 ? 173  PRO A N   1 
ATOM   751  C CA  . PRO A 1 153 ? -18.076 -7.837  -26.601 1.00 188.04 ? 173  PRO A CA  1 
ATOM   752  C C   . PRO A 1 153 ? -19.368 -8.362  -27.197 1.00 189.15 ? 173  PRO A C   1 
ATOM   753  O O   . PRO A 1 153 ? -20.441 -7.830  -26.882 1.00 188.68 ? 173  PRO A O   1 
ATOM   754  C CB  . PRO A 1 153 ? -17.506 -6.687  -27.437 1.00 186.07 ? 173  PRO A CB  1 
ATOM   755  C CG  . PRO A 1 153 ? -16.024 -6.855  -27.408 1.00 184.71 ? 173  PRO A CG  1 
ATOM   756  C CD  . PRO A 1 153 ? -15.761 -8.318  -27.249 1.00 186.16 ? 173  PRO A CD  1 
ATOM   757  N N   . LEU A 1 154 ? -19.306 -9.375  -28.062 1.00 201.84 ? 174  LEU A N   1 
ATOM   758  C CA  . LEU A 1 154 ? -20.534 -10.000 -28.538 1.00 206.42 ? 174  LEU A CA  1 
ATOM   759  C C   . LEU A 1 154 ? -21.296 -10.645 -27.385 1.00 193.16 ? 174  LEU A C   1 
ATOM   760  O O   . LEU A 1 154 ? -22.516 -10.481 -27.269 1.00 217.88 ? 174  LEU A O   1 
ATOM   761  C CB  . LEU A 1 154 ? -20.211 -11.022 -29.630 1.00 194.99 ? 174  LEU A CB  1 
ATOM   762  C CG  . LEU A 1 154 ? -19.215 -12.128 -29.275 1.00 213.69 ? 174  LEU A CG  1 
ATOM   763  C CD1 . LEU A 1 154 ? -19.940 -13.406 -28.871 1.00 195.65 ? 174  LEU A CD1 1 
ATOM   764  C CD2 . LEU A 1 154 ? -18.267 -12.388 -30.440 1.00 182.27 ? 174  LEU A CD2 1 
ATOM   765  N N   . THR A 1 155 ? -20.590 -11.363 -26.505 1.00 198.61 ? 175  THR A N   1 
ATOM   766  C CA  . THR A 1 155 ? -21.225 -11.886 -25.301 1.00 191.22 ? 175  THR A CA  1 
ATOM   767  C C   . THR A 1 155 ? -21.636 -10.768 -24.355 1.00 192.32 ? 175  THR A C   1 
ATOM   768  O O   . THR A 1 155 ? -22.449 -10.998 -23.453 1.00 206.30 ? 175  THR A O   1 
ATOM   769  C CB  . THR A 1 155 ? -20.294 -12.857 -24.569 1.00 224.64 ? 175  THR A CB  1 
ATOM   770  O OG1 . THR A 1 155 ? -19.229 -12.129 -23.944 1.00 205.43 ? 175  THR A OG1 1 
ATOM   771  C CG2 . THR A 1 155 ? -19.714 -13.882 -25.535 1.00 189.50 ? 175  THR A CG2 1 
ATOM   772  N N   . TYR A 1 156 ? -21.095 -9.564  -24.548 1.00 181.32 ? 176  TYR A N   1 
ATOM   773  C CA  . TYR A 1 156 ? -21.506 -8.383  -23.793 1.00 190.75 ? 176  TYR A CA  1 
ATOM   774  C C   . TYR A 1 156 ? -22.861 -7.907  -24.323 1.00 175.10 ? 176  TYR A C   1 
ATOM   775  O O   . TYR A 1 156 ? -23.031 -6.790  -24.811 1.00 186.88 ? 176  TYR A O   1 
ATOM   776  C CB  . TYR A 1 156 ? -20.432 -7.307  -23.902 1.00 209.93 ? 176  TYR A CB  1 
ATOM   777  C CG  . TYR A 1 156 ? -20.490 -6.208  -22.860 1.00 184.53 ? 176  TYR A CG  1 
ATOM   778  C CD1 . TYR A 1 156 ? -20.103 -6.441  -21.545 1.00 189.38 ? 176  TYR A CD1 1 
ATOM   779  C CD2 . TYR A 1 156 ? -20.901 -4.927  -23.201 1.00 192.57 ? 176  TYR A CD2 1 
ATOM   780  C CE1 . TYR A 1 156 ? -20.146 -5.433  -20.595 1.00 172.50 ? 176  TYR A CE1 1 
ATOM   781  C CE2 . TYR A 1 156 ? -20.945 -3.914  -22.259 1.00 180.47 ? 176  TYR A CE2 1 
ATOM   782  C CZ  . TYR A 1 156 ? -20.566 -4.172  -20.960 1.00 168.49 ? 176  TYR A CZ  1 
ATOM   783  O OH  . TYR A 1 156 ? -20.611 -3.165  -20.023 1.00 155.56 ? 176  TYR A OH  1 
ATOM   784  N N   . TYR A 1 157 ? -23.835 -8.810  -24.232 1.00 185.66 ? 177  TYR A N   1 
ATOM   785  C CA  . TYR A 1 157 ? -25.178 -8.555  -24.721 1.00 198.48 ? 177  TYR A CA  1 
ATOM   786  C C   . TYR A 1 157 ? -25.964 -7.737  -23.704 1.00 198.69 ? 177  TYR A C   1 
ATOM   787  O O   . TYR A 1 157 ? -25.652 -7.711  -22.510 1.00 209.70 ? 177  TYR A O   1 
ATOM   788  C CB  . TYR A 1 157 ? -25.905 -9.868  -25.013 1.00 198.89 ? 177  TYR A CB  1 
ATOM   789  N N   . SER A 1 158 ? -27.012 -7.076  -24.193 1.00 193.07 ? 178  SER A N   1 
ATOM   790  C CA  . SER A 1 158 ? -27.729 -6.117  -23.361 1.00 188.37 ? 178  SER A CA  1 
ATOM   791  C C   . SER A 1 158 ? -28.362 -6.788  -22.148 1.00 199.95 ? 178  SER A C   1 
ATOM   792  O O   . SER A 1 158 ? -28.346 -6.229  -21.046 1.00 185.16 ? 178  SER A O   1 
ATOM   793  C CB  . SER A 1 158 ? -28.789 -5.397  -24.194 1.00 203.77 ? 178  SER A CB  1 
ATOM   794  O OG  . SER A 1 158 ? -28.194 -4.723  -25.290 1.00 218.08 ? 178  SER A OG  1 
ATOM   795  N N   . ARG A 1 159 ? -28.923 -7.986  -22.322 1.00 195.32 ? 179  ARG A N   1 
ATOM   796  C CA  . ARG A 1 159 ? -29.640 -8.623  -21.221 1.00 188.32 ? 179  ARG A CA  1 
ATOM   797  C C   . ARG A 1 159 ? -28.716 -8.864  -20.033 1.00 178.28 ? 179  ARG A C   1 
ATOM   798  O O   . ARG A 1 159 ? -28.916 -8.300  -18.950 1.00 168.89 ? 179  ARG A O   1 
ATOM   799  C CB  . ARG A 1 159 ? -30.283 -9.931  -21.690 1.00 207.40 ? 179  ARG A CB  1 
ATOM   800  C CG  . ARG A 1 159 ? -29.332 -10.943 -22.311 1.00 206.47 ? 179  ARG A CG  1 
ATOM   801  C CD  . ARG A 1 159 ? -30.100 -12.015 -23.055 1.00 212.31 ? 179  ARG A CD  1 
ATOM   802  N NE  . ARG A 1 159 ? -29.232 -12.808 -23.915 1.00 203.25 ? 179  ARG A NE  1 
ATOM   803  C CZ  . ARG A 1 159 ? -28.586 -13.902 -23.534 1.00 208.67 ? 179  ARG A CZ  1 
ATOM   804  N NH1 . ARG A 1 159 ? -28.674 -14.364 -22.296 1.00 207.34 ? 179  ARG A NH1 1 
ATOM   805  N NH2 . ARG A 1 159 ? -27.832 -14.549 -24.417 1.00 228.41 ? 179  ARG A NH2 1 
ATOM   806  N N   . ARG A 1 160 ? -27.686 -9.693  -20.222 1.00 202.48 ? 180  ARG A N   1 
ATOM   807  C CA  . ARG A 1 160 ? -26.827 -10.051 -19.102 1.00 181.36 ? 180  ARG A CA  1 
ATOM   808  C C   . ARG A 1 160 ? -26.050 -8.850  -18.591 1.00 183.47 ? 180  ARG A C   1 
ATOM   809  O O   . ARG A 1 160 ? -25.792 -8.757  -17.392 1.00 167.15 ? 180  ARG A O   1 
ATOM   810  C CB  . ARG A 1 160 ? -25.863 -11.168 -19.496 1.00 193.32 ? 180  ARG A CB  1 
ATOM   811  C CG  . ARG A 1 160 ? -24.877 -11.532 -18.394 1.00 187.39 ? 180  ARG A CG  1 
ATOM   812  C CD  . ARG A 1 160 ? -24.437 -12.979 -18.506 1.00 215.05 ? 180  ARG A CD  1 
ATOM   813  N NE  . ARG A 1 160 ? -23.405 -13.315 -17.533 1.00 204.92 ? 180  ARG A NE  1 
ATOM   814  C CZ  . ARG A 1 160 ? -22.123 -13.001 -17.662 1.00 180.51 ? 180  ARG A CZ  1 
ATOM   815  N NH1 . ARG A 1 160 ? -21.683 -12.307 -18.699 1.00 188.73 ? 180  ARG A NH1 1 
ATOM   816  N NH2 . ARG A 1 160 ? -21.262 -13.393 -16.727 1.00 156.37 ? 180  ARG A NH2 1 
ATOM   817  N N   . THR A 1 161 ? -25.684 -7.916  -19.469 1.00 183.65 ? 181  THR A N   1 
ATOM   818  C CA  . THR A 1 161 ? -24.888 -6.774  -19.030 1.00 173.12 ? 181  THR A CA  1 
ATOM   819  C C   . THR A 1 161 ? -25.715 -5.791  -18.207 1.00 180.78 ? 181  THR A C   1 
ATOM   820  O O   . THR A 1 161 ? -25.269 -5.335  -17.152 1.00 189.06 ? 181  THR A O   1 
ATOM   821  C CB  . THR A 1 161 ? -24.264 -6.071  -20.234 1.00 177.98 ? 181  THR A CB  1 
ATOM   822  O OG1 . THR A 1 161 ? -25.291 -5.678  -21.151 1.00 193.62 ? 181  THR A OG1 1 
ATOM   823  C CG2 . THR A 1 161 ? -23.277 -6.995  -20.928 1.00 176.98 ? 181  THR A CG2 1 
ATOM   824  N N   . LEU A 1 162 ? -26.915 -5.432  -18.675 1.00 165.14 ? 182  LEU A N   1 
ATOM   825  C CA  . LEU A 1 162 ? -27.772 -4.562  -17.874 1.00 162.09 ? 182  LEU A CA  1 
ATOM   826  C C   . LEU A 1 162 ? -28.163 -5.248  -16.575 1.00 193.49 ? 182  LEU A C   1 
ATOM   827  O O   . LEU A 1 162 ? -28.160 -4.626  -15.501 1.00 179.88 ? 182  LEU A O   1 
ATOM   828  C CB  . LEU A 1 162 ? -29.024 -4.167  -18.658 1.00 162.87 ? 182  LEU A CB  1 
ATOM   829  C CG  . LEU A 1 162 ? -28.961 -2.910  -19.531 1.00 172.37 ? 182  LEU A CG  1 
ATOM   830  C CD1 . LEU A 1 162 ? -28.670 -1.661  -18.704 1.00 165.04 ? 182  LEU A CD1 1 
ATOM   831  C CD2 . LEU A 1 162 ? -27.934 -3.070  -20.637 1.00 178.11 ? 182  LEU A CD2 1 
ATOM   832  N N   . LEU A 1 163 ? -28.506 -6.535  -16.655 1.00 181.63 ? 183  LEU A N   1 
ATOM   833  C CA  . LEU A 1 163 ? -28.774 -7.313  -15.457 1.00 177.27 ? 183  LEU A CA  1 
ATOM   834  C C   . LEU A 1 163 ? -27.607 -7.221  -14.489 1.00 192.55 ? 183  LEU A C   1 
ATOM   835  O O   . LEU A 1 163 ? -27.780 -6.872  -13.317 1.00 183.26 ? 183  LEU A O   1 
ATOM   836  C CB  . LEU A 1 163 ? -29.034 -8.763  -15.859 1.00 192.24 ? 183  LEU A CB  1 
ATOM   837  C CG  . LEU A 1 163 ? -29.150 -9.801  -14.750 1.00 169.21 ? 183  LEU A CG  1 
ATOM   838  C CD1 . LEU A 1 163 ? -30.521 -9.718  -14.109 1.00 163.01 ? 183  LEU A CD1 1 
ATOM   839  C CD2 . LEU A 1 163 ? -28.877 -11.190 -15.310 1.00 177.96 ? 183  LEU A CD2 1 
ATOM   840  N N   . GLY A 1 164 ? -26.402 -7.513  -14.976 1.00 159.60 ? 184  GLY A N   1 
ATOM   841  C CA  . GLY A 1 164 ? -25.237 -7.484  -14.120 1.00 167.11 ? 184  GLY A CA  1 
ATOM   842  C C   . GLY A 1 164 ? -24.982 -6.114  -13.534 1.00 163.72 ? 184  GLY A C   1 
ATOM   843  O O   . GLY A 1 164 ? -24.640 -5.994  -12.366 1.00 161.82 ? 184  GLY A O   1 
ATOM   844  N N   . VAL A 1 165 ? -25.155 -5.063  -14.331 1.00 164.92 ? 185  VAL A N   1 
ATOM   845  C CA  . VAL A 1 165 ? -24.843 -3.717  -13.860 1.00 163.70 ? 185  VAL A CA  1 
ATOM   846  C C   . VAL A 1 165 ? -25.794 -3.308  -12.743 1.00 169.53 ? 185  VAL A C   1 
ATOM   847  O O   . VAL A 1 165 ? -25.372 -2.808  -11.690 1.00 166.76 ? 185  VAL A O   1 
ATOM   848  C CB  . VAL A 1 165 ? -24.889 -2.721  -15.031 1.00 154.48 ? 185  VAL A CB  1 
ATOM   849  C CG1 . VAL A 1 165 ? -24.764 -1.290  -14.526 1.00 138.61 ? 185  VAL A CG1 1 
ATOM   850  C CG2 . VAL A 1 165 ? -23.787 -3.041  -16.014 1.00 166.12 ? 185  VAL A CG2 1 
ATOM   851  N N   . HIS A 1 166 ? -27.095 -3.505  -12.955 1.00 171.96 ? 186  HIS A N   1 
ATOM   852  C CA  . HIS A 1 166 ? -28.049 -3.140  -11.915 1.00 180.19 ? 186  HIS A CA  1 
ATOM   853  C C   . HIS A 1 166 ? -27.876 -4.028  -10.684 1.00 188.59 ? 186  HIS A C   1 
ATOM   854  O O   . HIS A 1 166 ? -27.970 -3.548  -9.545  1.00 170.24 ? 186  HIS A O   1 
ATOM   855  C CB  . HIS A 1 166 ? -29.468 -3.200  -12.479 1.00 179.21 ? 186  HIS A CB  1 
ATOM   856  C CG  . HIS A 1 166 ? -29.694 -2.260  -13.627 1.00 187.75 ? 186  HIS A CG  1 
ATOM   857  N ND1 . HIS A 1 166 ? -29.619 -0.890  -13.494 1.00 194.10 ? 186  HIS A ND1 1 
ATOM   858  C CD2 . HIS A 1 166 ? -29.983 -2.494  -14.930 1.00 198.44 ? 186  HIS A CD2 1 
ATOM   859  C CE1 . HIS A 1 166 ? -29.855 -0.320  -14.663 1.00 202.58 ? 186  HIS A CE1 1 
ATOM   860  N NE2 . HIS A 1 166 ? -30.079 -1.271  -15.551 1.00 183.73 ? 186  HIS A NE2 1 
ATOM   861  N N   . LEU A 1 167 ? -27.569 -5.314  -10.891 1.00 174.27 ? 187  LEU A N   1 
ATOM   862  C CA  . LEU A 1 167 ? -27.257 -6.199  -9.774  1.00 190.66 ? 187  LEU A CA  1 
ATOM   863  C C   . LEU A 1 167 ? -26.035 -5.714  -9.006  1.00 169.04 ? 187  LEU A C   1 
ATOM   864  O O   . LEU A 1 167 ? -26.001 -5.776  -7.774  1.00 152.46 ? 187  LEU A O   1 
ATOM   865  C CB  . LEU A 1 167 ? -27.014 -7.616  -10.291 1.00 158.49 ? 187  LEU A CB  1 
ATOM   866  C CG  . LEU A 1 167 ? -28.183 -8.598  -10.351 1.00 166.63 ? 187  LEU A CG  1 
ATOM   867  C CD1 . LEU A 1 167 ? -29.411 -8.002  -11.022 1.00 177.73 ? 187  LEU A CD1 1 
ATOM   868  C CD2 . LEU A 1 167 ? -27.727 -9.853  -11.085 1.00 176.48 ? 187  LEU A CD2 1 
ATOM   869  N N   . LEU A 1 168 ? -25.002 -5.273  -9.724  1.00 187.26 ? 188  LEU A N   1 
ATOM   870  C CA  . LEU A 1 168 ? -23.785 -4.802  -9.079  1.00 174.61 ? 188  LEU A CA  1 
ATOM   871  C C   . LEU A 1 168 ? -24.073 -3.580  -8.227  1.00 175.18 ? 188  LEU A C   1 
ATOM   872  O O   . LEU A 1 168 ? -23.611 -3.484  -7.086  1.00 169.46 ? 188  LEU A O   1 
ATOM   873  C CB  . LEU A 1 168 ? -22.723 -4.474  -10.132 1.00 168.97 ? 188  LEU A CB  1 
ATOM   874  C CG  . LEU A 1 168 ? -22.089 -5.609  -10.946 1.00 170.41 ? 188  LEU A CG  1 
ATOM   875  C CD1 . LEU A 1 168 ? -21.248 -5.035  -12.085 1.00 171.85 ? 188  LEU A CD1 1 
ATOM   876  C CD2 . LEU A 1 168 ? -21.253 -6.528  -10.076 1.00 205.22 ? 188  LEU A CD2 1 
ATOM   877  N N   . LEU A 1 169 ? -24.841 -2.632  -8.764  1.00 168.44 ? 189  LEU A N   1 
ATOM   878  C CA  . LEU A 1 169 ? -25.182 -1.455  -7.972  1.00 178.14 ? 189  LEU A CA  1 
ATOM   879  C C   . LEU A 1 169 ? -25.965 -1.852  -6.727  1.00 175.45 ? 189  LEU A C   1 
ATOM   880  O O   . LEU A 1 169 ? -25.698 -1.348  -5.626  1.00 178.27 ? 189  LEU A O   1 
ATOM   881  C CB  . LEU A 1 169 ? -25.974 -0.454  -8.814  1.00 189.65 ? 189  LEU A CB  1 
ATOM   882  C CG  . LEU A 1 169 ? -25.224 0.235   -9.958  1.00 180.69 ? 189  LEU A CG  1 
ATOM   883  C CD1 . LEU A 1 169 ? -26.007 1.446   -10.455 1.00 195.89 ? 189  LEU A CD1 1 
ATOM   884  C CD2 . LEU A 1 169 ? -23.816 0.641   -9.541  1.00 169.49 ? 189  LEU A CD2 1 
ATOM   885  N N   . ALA A 1 170 ? -26.927 -2.767  -6.876  1.00 174.36 ? 190  ALA A N   1 
ATOM   886  C CA  . ALA A 1 170 ? -27.703 -3.204  -5.720  1.00 177.89 ? 190  ALA A CA  1 
ATOM   887  C C   . ALA A 1 170 ? -26.804 -3.849  -4.670  1.00 185.06 ? 190  ALA A C   1 
ATOM   888  O O   . ALA A 1 170 ? -26.825 -3.464  -3.495  1.00 179.71 ? 190  ALA A O   1 
ATOM   889  C CB  . ALA A 1 170 ? -28.798 -4.174  -6.163  1.00 175.07 ? 190  ALA A CB  1 
ATOM   890  N N   . ALA A 1 171 ? -25.999 -4.834  -5.080  1.00 173.21 ? 191  ALA A N   1 
ATOM   891  C CA  . ALA A 1 171 ? -25.163 -5.575  -4.143  1.00 178.53 ? 191  ALA A CA  1 
ATOM   892  C C   . ALA A 1 171 ? -24.039 -4.725  -3.571  1.00 164.80 ? 191  ALA A C   1 
ATOM   893  O O   . ALA A 1 171 ? -23.477 -5.083  -2.531  1.00 165.12 ? 191  ALA A O   1 
ATOM   894  C CB  . ALA A 1 171 ? -24.574 -6.812  -4.825  1.00 164.78 ? 191  ALA A CB  1 
ATOM   895  N N   . THR A 1 172 ? -23.691 -3.619  -4.229  1.00 186.07 ? 192  THR A N   1 
ATOM   896  C CA  . THR A 1 172 ? -22.700 -2.709  -3.673  1.00 167.13 ? 192  THR A CA  1 
ATOM   897  C C   . THR A 1 172 ? -23.322 -1.805  -2.623  1.00 176.78 ? 192  THR A C   1 
ATOM   898  O O   . THR A 1 172 ? -22.827 -1.721  -1.495  1.00 175.83 ? 192  THR A O   1 
ATOM   899  C CB  . THR A 1 172 ? -22.073 -1.860  -4.780  1.00 177.44 ? 192  THR A CB  1 
ATOM   900  O OG1 . THR A 1 172 ? -21.258 -2.685  -5.619  1.00 185.88 ? 192  THR A OG1 1 
ATOM   901  C CG2 . THR A 1 172 ? -21.227 -0.742  -4.179  1.00 162.50 ? 192  THR A CG2 1 
ATOM   902  N N   . TRP A 1 173 ? -24.400 -1.107  -2.983  1.00 167.52 ? 193  TRP A N   1 
ATOM   903  C CA  . TRP A 1 173 ? -24.975 -0.141  -2.055  1.00 197.75 ? 193  TRP A CA  1 
ATOM   904  C C   . TRP A 1 173 ? -25.594 -0.829  -0.848  1.00 154.80 ? 193  TRP A C   1 
ATOM   905  O O   . TRP A 1 173 ? -25.461 -0.340  0.280   1.00 165.94 ? 193  TRP A O   1 
ATOM   906  C CB  . TRP A 1 173 ? -25.984 0.735   -2.786  1.00 176.20 ? 193  TRP A CB  1 
ATOM   907  C CG  . TRP A 1 173 ? -25.276 1.656   -3.701  1.00 181.55 ? 193  TRP A CG  1 
ATOM   908  C CD1 . TRP A 1 173 ? -25.185 1.560   -5.054  1.00 160.18 ? 193  TRP A CD1 1 
ATOM   909  C CD2 . TRP A 1 173 ? -24.505 2.799   -3.324  1.00 160.00 ? 193  TRP A CD2 1 
ATOM   910  N NE1 . TRP A 1 173 ? -24.419 2.587   -5.549  1.00 174.46 ? 193  TRP A NE1 1 
ATOM   911  C CE2 . TRP A 1 173 ? -23.990 3.362   -4.504  1.00 167.68 ? 193  TRP A CE2 1 
ATOM   912  C CE3 . TRP A 1 173 ? -24.209 3.406   -2.100  1.00 171.16 ? 193  TRP A CE3 1 
ATOM   913  C CZ2 . TRP A 1 173 ? -23.197 4.504   -4.500  1.00 147.00 ? 193  TRP A CZ2 1 
ATOM   914  C CZ3 . TRP A 1 173 ? -23.422 4.542   -2.098  1.00 163.20 ? 193  TRP A CZ3 1 
ATOM   915  C CH2 . TRP A 1 173 ? -22.925 5.079   -3.290  1.00 152.45 ? 193  TRP A CH2 1 
ATOM   916  N N   . THR A 1 174 ? -26.249 -1.973  -1.051  1.00 158.50 ? 194  THR A N   1 
ATOM   917  C CA  . THR A 1 174 ? -26.784 -2.720  0.081   1.00 177.11 ? 194  THR A CA  1 
ATOM   918  C C   . THR A 1 174 ? -25.682 -3.067  1.078   1.00 170.78 ? 194  THR A C   1 
ATOM   919  O O   . THR A 1 174 ? -25.797 -2.782  2.277   1.00 167.91 ? 194  THR A O   1 
ATOM   920  C CB  . THR A 1 174 ? -27.475 -3.990  -0.423  1.00 181.67 ? 194  THR A CB  1 
ATOM   921  O OG1 . THR A 1 174 ? -26.552 -4.765  -1.201  1.00 175.01 ? 194  THR A OG1 1 
ATOM   922  C CG2 . THR A 1 174 ? -28.692 -3.645  -1.281  1.00 190.42 ? 194  THR A CG2 1 
ATOM   923  N N   . VAL A 1 175 ? -24.595 -3.673  0.594   1.00 168.74 ? 195  VAL A N   1 
ATOM   924  C CA  . VAL A 1 175 ? -23.521 -4.107  1.484   1.00 160.51 ? 195  VAL A CA  1 
ATOM   925  C C   . VAL A 1 175 ? -22.872 -2.906  2.160   1.00 157.69 ? 195  VAL A C   1 
ATOM   926  O O   . VAL A 1 175 ? -22.613 -2.918  3.372   1.00 165.99 ? 195  VAL A O   1 
ATOM   927  C CB  . VAL A 1 175 ? -22.488 -4.944  0.703   1.00 165.68 ? 195  VAL A CB  1 
ATOM   928  C CG1 . VAL A 1 175 ? -21.290 -5.266  1.578   1.00 157.67 ? 195  VAL A CG1 1 
ATOM   929  C CG2 . VAL A 1 175 ? -23.123 -6.228  0.175   1.00 167.42 ? 195  VAL A CG2 1 
ATOM   930  N N   . SER A 1 176 ? -22.592 -1.852  1.390   1.00 160.92 ? 196  SER A N   1 
ATOM   931  C CA  . SER A 1 176 ? -21.916 -0.688  1.950   1.00 162.23 ? 196  SER A CA  1 
ATOM   932  C C   . SER A 1 176 ? -22.758 -0.039  3.039   1.00 157.97 ? 196  SER A C   1 
ATOM   933  O O   . SER A 1 176 ? -22.240 0.334   4.099   1.00 153.96 ? 196  SER A O   1 
ATOM   934  C CB  . SER A 1 176 ? -21.606 0.320   0.842   1.00 169.07 ? 196  SER A CB  1 
ATOM   935  O OG  . SER A 1 176 ? -20.788 -0.252  -0.166  1.00 173.30 ? 196  SER A OG  1 
ATOM   936  N N   . LEU A 1 177 ? -24.063 0.103   2.799   1.00 156.93 ? 197  LEU A N   1 
ATOM   937  C CA  . LEU A 1 177 ? -24.933 0.696   3.806   1.00 159.39 ? 197  LEU A CA  1 
ATOM   938  C C   . LEU A 1 177 ? -25.048 -0.204  5.030   1.00 168.15 ? 197  LEU A C   1 
ATOM   939  O O   . LEU A 1 177 ? -25.037 0.283   6.166   1.00 154.88 ? 197  LEU A O   1 
ATOM   940  C CB  . LEU A 1 177 ? -26.301 0.984   3.189   1.00 172.84 ? 197  LEU A CB  1 
ATOM   941  C CG  . LEU A 1 177 ? -26.247 2.001   2.041   1.00 179.29 ? 197  LEU A CG  1 
ATOM   942  C CD1 . LEU A 1 177 ? -27.511 1.972   1.193   1.00 189.86 ? 197  LEU A CD1 1 
ATOM   943  C CD2 . LEU A 1 177 ? -26.004 3.402   2.589   1.00 185.38 ? 197  LEU A CD2 1 
ATOM   944  N N   . GLY A 1 178 ? -25.143 -1.520  4.830   1.00 160.68 ? 198  GLY A N   1 
ATOM   945  C CA  . GLY A 1 178 ? -25.171 -2.418  5.972   1.00 166.21 ? 198  GLY A CA  1 
ATOM   946  C C   . GLY A 1 178 ? -23.938 -2.273  6.840   1.00 139.46 ? 198  GLY A C   1 
ATOM   947  O O   . GLY A 1 178 ? -24.030 -2.215  8.071   1.00 146.37 ? 198  GLY A O   1 
ATOM   948  N N   . LEU A 1 179 ? -22.765 -2.206  6.211   1.00 139.42 ? 199  LEU A N   1 
ATOM   949  C CA  . LEU A 1 179 ? -21.538 -1.990  6.968   1.00 140.56 ? 199  LEU A CA  1 
ATOM   950  C C   . LEU A 1 179 ? -21.579 -0.652  7.697   1.00 141.05 ? 199  LEU A C   1 
ATOM   951  O O   . LEU A 1 179 ? -21.265 -0.572  8.890   1.00 171.06 ? 199  LEU A O   1 
ATOM   952  C CB  . LEU A 1 179 ? -20.327 -2.061  6.039   1.00 163.79 ? 199  LEU A CB  1 
ATOM   953  C CG  . LEU A 1 179 ? -19.727 -3.443  5.748   1.00 169.62 ? 199  LEU A CG  1 
ATOM   954  C CD1 . LEU A 1 179 ? -19.259 -4.124  7.029   1.00 184.91 ? 199  LEU A CD1 1 
ATOM   955  C CD2 . LEU A 1 179 ? -20.699 -4.340  4.994   1.00 174.25 ? 199  LEU A CD2 1 
ATOM   956  N N   . GLY A 1 180 ? -21.981 0.412   6.999   1.00 153.23 ? 200  GLY A N   1 
ATOM   957  C CA  . GLY A 1 180 ? -22.054 1.714   7.640   1.00 170.41 ? 200  GLY A CA  1 
ATOM   958  C C   . GLY A 1 180 ? -22.990 1.728   8.831   1.00 164.21 ? 200  GLY A C   1 
ATOM   959  O O   . GLY A 1 180 ? -22.807 2.515   9.762   1.00 168.65 ? 200  GLY A O   1 
ATOM   960  N N   . LEU A 1 181 ? -23.998 0.861   8.821   1.00 167.39 ? 201  LEU A N   1 
ATOM   961  C CA  . LEU A 1 181 ? -24.944 0.788   9.926   1.00 167.61 ? 201  LEU A CA  1 
ATOM   962  C C   . LEU A 1 181 ? -24.488 -0.130  11.050  1.00 155.80 ? 201  LEU A C   1 
ATOM   963  O O   . LEU A 1 181 ? -24.924 0.053   12.192  1.00 149.60 ? 201  LEU A O   1 
ATOM   964  C CB  . LEU A 1 181 ? -26.306 0.318   9.413   1.00 156.45 ? 201  LEU A CB  1 
ATOM   965  C CG  . LEU A 1 181 ? -26.914 1.233   8.350   1.00 193.96 ? 201  LEU A CG  1 
ATOM   966  C CD1 . LEU A 1 181 ? -28.163 0.600   7.757   1.00 191.86 ? 201  LEU A CD1 1 
ATOM   967  C CD2 . LEU A 1 181 ? -27.215 2.612   8.918   1.00 161.65 ? 201  LEU A CD2 1 
ATOM   968  N N   . LEU A 1 182 ? -23.623 -1.102  10.762  1.00 166.83 ? 202  LEU A N   1 
ATOM   969  C CA  . LEU A 1 182 ? -23.156 -2.016  11.804  1.00 161.28 ? 202  LEU A CA  1 
ATOM   970  C C   . LEU A 1 182 ? -22.684 -1.306  13.068  1.00 155.03 ? 202  LEU A C   1 
ATOM   971  O O   . LEU A 1 182 ? -23.063 -1.743  14.166  1.00 162.81 ? 202  LEU A O   1 
ATOM   972  C CB  . LEU A 1 182 ? -22.031 -2.904  11.257  1.00 162.21 ? 202  LEU A CB  1 
ATOM   973  C CG  . LEU A 1 182 ? -22.444 -4.132  10.445  1.00 132.99 ? 202  LEU A CG  1 
ATOM   974  C CD1 . LEU A 1 182 ? -21.213 -4.918  10.037  1.00 147.81 ? 202  LEU A CD1 1 
ATOM   975  C CD2 . LEU A 1 182 ? -23.400 -5.021  11.222  1.00 147.93 ? 202  LEU A CD2 1 
ATOM   976  N N   . PRO A 1 183 ? -21.883 -0.236  13.007  1.00 156.54 ? 203  PRO A N   1 
ATOM   977  C CA  . PRO A 1 183 ? -21.523 0.450   14.258  1.00 186.29 ? 203  PRO A CA  1 
ATOM   978  C C   . PRO A 1 183 ? -22.738 0.937   15.017  1.00 192.04 ? 203  PRO A C   1 
ATOM   979  O O   . PRO A 1 183 ? -22.685 1.081   16.244  1.00 183.88 ? 203  PRO A O   1 
ATOM   980  C CB  . PRO A 1 183 ? -20.639 1.615   13.785  1.00 146.17 ? 203  PRO A CB  1 
ATOM   981  C CG  . PRO A 1 183 ? -20.977 1.801   12.354  1.00 160.81 ? 203  PRO A CG  1 
ATOM   982  C CD  . PRO A 1 183 ? -21.286 0.428   11.837  1.00 170.63 ? 203  PRO A CD  1 
ATOM   983  N N   . VAL A 1 184 ? -23.839 1.197   14.312  1.00 157.26 ? 204  VAL A N   1 
ATOM   984  C CA  . VAL A 1 184 ? -25.077 1.571   14.981  1.00 176.97 ? 204  VAL A CA  1 
ATOM   985  C C   . VAL A 1 184 ? -25.659 0.377   15.730  1.00 174.22 ? 204  VAL A C   1 
ATOM   986  O O   . VAL A 1 184 ? -26.213 0.525   16.825  1.00 147.26 ? 204  VAL A O   1 
ATOM   987  C CB  . VAL A 1 184 ? -26.079 2.146   13.962  1.00 160.29 ? 204  VAL A CB  1 
ATOM   988  C CG1 . VAL A 1 184 ? -27.205 2.860   14.684  1.00 170.33 ? 204  VAL A CG1 1 
ATOM   989  C CG2 . VAL A 1 184 ? -25.384 3.088   12.969  1.00 193.02 ? 204  VAL A CG2 1 
ATOM   990  N N   . LEU A 1 185 ? -25.545 -0.822  15.152  1.00 167.60 ? 205  LEU A N   1 
ATOM   991  C CA  . LEU A 1 185 ? -26.119 -2.010  15.774  1.00 186.30 ? 205  LEU A CA  1 
ATOM   992  C C   . LEU A 1 185 ? -25.417 -2.396  17.068  1.00 174.42 ? 205  LEU A C   1 
ATOM   993  O O   . LEU A 1 185 ? -25.973 -3.178  17.848  1.00 166.12 ? 205  LEU A O   1 
ATOM   994  C CB  . LEU A 1 185 ? -26.066 -3.195  14.809  1.00 185.16 ? 205  LEU A CB  1 
ATOM   995  C CG  . LEU A 1 185 ? -27.159 -3.248  13.742  1.00 182.40 ? 205  LEU A CG  1 
ATOM   996  C CD1 . LEU A 1 185 ? -26.918 -2.211  12.656  1.00 177.46 ? 205  LEU A CD1 1 
ATOM   997  C CD2 . LEU A 1 185 ? -27.242 -4.647  13.154  1.00 168.59 ? 205  LEU A CD2 1 
ATOM   998  N N   . GLY A 1 186 ? -24.218 -1.877  17.310  1.00 174.86 ? 206  GLY A N   1 
ATOM   999  C CA  . GLY A 1 186 ? -23.451 -2.263  18.478  1.00 188.33 ? 206  GLY A CA  1 
ATOM   1000 C C   . GLY A 1 186 ? -22.102 -2.847  18.114  1.00 181.05 ? 206  GLY A C   1 
ATOM   1001 O O   . GLY A 1 186 ? -21.534 -3.646  18.866  1.00 202.28 ? 206  GLY A O   1 
ATOM   1002 N N   . TRP A 1 187 ? -21.584 -2.457  16.949  1.00 178.42 ? 207  TRP A N   1 
ATOM   1003 C CA  . TRP A 1 187 ? -20.267 -2.875  16.486  1.00 184.08 ? 207  TRP A CA  1 
ATOM   1004 C C   . TRP A 1 187 ? -19.265 -1.726  16.556  1.00 181.98 ? 207  TRP A C   1 
ATOM   1005 O O   . TRP A 1 187 ? -18.367 -1.619  15.716  1.00 153.34 ? 207  TRP A O   1 
ATOM   1006 C CB  . TRP A 1 187 ? -20.358 -3.437  15.066  1.00 163.68 ? 207  TRP A CB  1 
ATOM   1007 C CG  . TRP A 1 187 ? -21.209 -4.678  14.979  1.00 178.60 ? 207  TRP A CG  1 
ATOM   1008 C CD1 . TRP A 1 187 ? -22.572 -4.745  15.060  1.00 163.58 ? 207  TRP A CD1 1 
ATOM   1009 C CD2 . TRP A 1 187 ? -20.753 -6.026  14.800  1.00 181.32 ? 207  TRP A CD2 1 
ATOM   1010 N NE1 . TRP A 1 187 ? -22.990 -6.050  14.945  1.00 186.19 ? 207  TRP A NE1 1 
ATOM   1011 C CE2 . TRP A 1 187 ? -21.894 -6.855  14.783  1.00 194.43 ? 207  TRP A CE2 1 
ATOM   1012 C CE3 . TRP A 1 187 ? -19.491 -6.613  14.652  1.00 174.31 ? 207  TRP A CE3 1 
ATOM   1013 C CZ2 . TRP A 1 187 ? -21.811 -8.238  14.623  1.00 181.16 ? 207  TRP A CZ2 1 
ATOM   1014 C CZ3 . TRP A 1 187 ? -19.411 -7.987  14.493  1.00 196.43 ? 207  TRP A CZ3 1 
ATOM   1015 C CH2 . TRP A 1 187 ? -20.564 -8.783  14.480  1.00 199.25 ? 207  TRP A CH2 1 
ATOM   1016 N N   . ASN A 1 188 ? -19.418 -0.858  17.555  1.00 172.46 ? 208  ASN A N   1 
ATOM   1017 C CA  . ASN A 1 188 ? -18.534 0.271   17.785  1.00 170.47 ? 208  ASN A CA  1 
ATOM   1018 C C   . ASN A 1 188 ? -17.564 -0.060  18.921  1.00 179.83 ? 208  ASN A C   1 
ATOM   1019 O O   . ASN A 1 188 ? -17.499 -1.196  19.403  1.00 194.84 ? 208  ASN A O   1 
ATOM   1020 C CB  . ASN A 1 188 ? -19.357 1.529   18.072  1.00 167.31 ? 208  ASN A CB  1 
ATOM   1021 C CG  . ASN A 1 188 ? -20.391 1.313   19.152  1.00 189.71 ? 208  ASN A CG  1 
ATOM   1022 O OD1 . ASN A 1 188 ? -21.074 0.289   19.176  1.00 203.92 ? 208  ASN A OD1 1 
ATOM   1023 N ND2 . ASN A 1 188 ? -20.510 2.275   20.057  1.00 200.06 ? 208  ASN A ND2 1 
ATOM   1024 N N   . CYS A 1 189 ? -16.799 0.942   19.358  1.00 169.05 ? 209  CYS A N   1 
ATOM   1025 C CA  . CYS A 1 189 ? -15.681 0.737   20.271  1.00 172.15 ? 209  CYS A CA  1 
ATOM   1026 C C   . CYS A 1 189 ? -15.928 1.316   21.657  1.00 189.05 ? 209  CYS A C   1 
ATOM   1027 O O   . CYS A 1 189 ? -14.976 1.498   22.421  1.00 191.60 ? 209  CYS A O   1 
ATOM   1028 C CB  . CYS A 1 189 ? -14.415 1.357   19.683  1.00 182.41 ? 209  CYS A CB  1 
ATOM   1029 S SG  . CYS A 1 189 ? -14.338 3.160   19.837  1.00 177.42 ? 209  CYS A SG  1 
ATOM   1030 N N   . LEU A 1 190 ? -17.184 1.593   22.010  1.00 207.23 ? 210  LEU A N   1 
ATOM   1031 C CA  . LEU A 1 190 ? -17.501 2.327   23.229  1.00 201.45 ? 210  LEU A CA  1 
ATOM   1032 C C   . LEU A 1 190 ? -17.807 1.410   24.412  1.00 205.21 ? 210  LEU A C   1 
ATOM   1033 O O   . LEU A 1 190 ? -18.638 1.757   25.262  1.00 224.07 ? 210  LEU A O   1 
ATOM   1034 C CB  . LEU A 1 190 ? -18.669 3.282   22.970  1.00 199.89 ? 210  LEU A CB  1 
ATOM   1035 C CG  . LEU A 1 190 ? -18.418 4.347   21.897  1.00 183.20 ? 210  LEU A CG  1 
ATOM   1036 C CD1 . LEU A 1 190 ? -19.641 5.236   21.731  1.00 179.01 ? 210  LEU A CD1 1 
ATOM   1037 C CD2 . LEU A 1 190 ? -17.184 5.195   22.207  1.00 173.61 ? 210  LEU A CD2 1 
ATOM   1038 N N   . ALA A 1 191 ? -17.150 0.253   24.498  1.00 217.44 ? 211  ALA A N   1 
ATOM   1039 C CA  . ALA A 1 191 ? -17.345 -0.690  25.590  1.00 201.38 ? 211  ALA A CA  1 
ATOM   1040 C C   . ALA A 1 191 ? -16.064 -0.838  26.402  1.00 203.91 ? 211  ALA A C   1 
ATOM   1041 O O   . ALA A 1 191 ? -14.955 -0.714  25.873  1.00 201.49 ? 211  ALA A O   1 
ATOM   1042 C CB  . ALA A 1 191 ? -17.779 -2.064  25.067  1.00 201.80 ? 211  ALA A CB  1 
ATOM   1043 N N   . GLU A 1 192 ? -16.229 -1.125  27.698  1.00 220.97 ? 212  GLU A N   1 
ATOM   1044 C CA  . GLU A 1 192 ? -15.095 -1.250  28.610  1.00 189.19 ? 212  GLU A CA  1 
ATOM   1045 C C   . GLU A 1 192 ? -14.193 -2.420  28.239  1.00 185.52 ? 212  GLU A C   1 
ATOM   1046 O O   . GLU A 1 192 ? -13.137 -2.605  28.858  1.00 172.38 ? 212  GLU A O   1 
ATOM   1047 C CB  . GLU A 1 192 ? -15.597 -1.412  30.048  1.00 182.39 ? 212  GLU A CB  1 
ATOM   1048 N N   . ARG A 1 193 ? -14.588 -3.212  27.242  1.00 208.72 ? 213  ARG A N   1 
ATOM   1049 C CA  . ARG A 1 193 ? -13.831 -4.376  26.802  1.00 205.29 ? 213  ARG A CA  1 
ATOM   1050 C C   . ARG A 1 193 ? -13.488 -4.314  25.316  1.00 180.82 ? 213  ARG A C   1 
ATOM   1051 O O   . ARG A 1 193 ? -13.164 -5.344  24.717  1.00 185.18 ? 213  ARG A O   1 
ATOM   1052 C CB  . ARG A 1 193 ? -14.619 -5.651  27.104  1.00 208.29 ? 213  ARG A CB  1 
ATOM   1053 C CG  . ARG A 1 193 ? -15.993 -5.670  26.452  1.00 200.34 ? 213  ARG A CG  1 
ATOM   1054 C CD  . ARG A 1 193 ? -16.823 -6.857  26.902  1.00 211.76 ? 213  ARG A CD  1 
ATOM   1055 N NE  . ARG A 1 193 ? -18.093 -6.924  26.187  1.00 219.40 ? 213  ARG A NE  1 
ATOM   1056 C CZ  . ARG A 1 193 ? -19.177 -6.231  26.510  1.00 205.20 ? 213  ARG A CZ  1 
ATOM   1057 N NH1 . ARG A 1 193 ? -19.187 -5.399  27.539  1.00 205.76 ? 213  ARG A NH1 1 
ATOM   1058 N NH2 . ARG A 1 193 ? -20.279 -6.375  25.779  1.00 197.30 ? 213  ARG A NH2 1 
ATOM   1059 N N   . ALA A 1 194 ? -13.555 -3.131  24.707  1.00 203.94 ? 214  ALA A N   1 
ATOM   1060 C CA  . ALA A 1 194 ? -13.285 -2.964  23.286  1.00 180.89 ? 214  ALA A CA  1 
ATOM   1061 C C   . ALA A 1 194 ? -12.390 -1.751  23.084  1.00 182.08 ? 214  ALA A C   1 
ATOM   1062 O O   . ALA A 1 194 ? -12.709 -0.655  23.556  1.00 172.18 ? 214  ALA A O   1 
ATOM   1063 C CB  . ALA A 1 194 ? -14.584 -2.800  22.491  1.00 183.29 ? 214  ALA A CB  1 
ATOM   1064 N N   . ALA A 1 195 ? -11.279 -1.948  22.379  1.00 167.88 ? 215  ALA A N   1 
ATOM   1065 C CA  . ALA A 1 195 ? -10.337 -0.868  22.129  1.00 161.82 ? 215  ALA A CA  1 
ATOM   1066 C C   . ALA A 1 195 ? -10.783 -0.040  20.934  1.00 160.71 ? 215  ALA A C   1 
ATOM   1067 O O   . ALA A 1 195 ? -11.285 -0.575  19.940  1.00 158.76 ? 215  ALA A O   1 
ATOM   1068 C CB  . ALA A 1 195 ? -8.935  -1.424  21.884  1.00 174.46 ? 215  ALA A CB  1 
ATOM   1069 N N   . CYS A 1 196 ? -10.590 1.272   21.034  1.00 177.52 ? 216  CYS A N   1 
ATOM   1070 C CA  . CYS A 1 196 ? -11.010 2.196   19.992  1.00 164.13 ? 216  CYS A CA  1 
ATOM   1071 C C   . CYS A 1 196 ? -9.894  2.413   18.981  1.00 168.92 ? 216  CYS A C   1 
ATOM   1072 O O   . CYS A 1 196 ? -8.726  2.576   19.347  1.00 168.59 ? 216  CYS A O   1 
ATOM   1073 C CB  . CYS A 1 196 ? -11.436 3.534   20.597  1.00 131.50 ? 216  CYS A CB  1 
ATOM   1074 S SG  . CYS A 1 196 ? -13.058 3.482   21.379  1.00 157.52 ? 216  CYS A SG  1 
ATOM   1075 N N   . SER A 1 197 ? -10.268 2.413   17.705  1.00 163.22 ? 217  SER A N   1 
ATOM   1076 C CA  . SER A 1 197 ? -9.321  2.650   16.632  1.00 168.93 ? 217  SER A CA  1 
ATOM   1077 C C   . SER A 1 197 ? -9.076  4.147   16.474  1.00 171.48 ? 217  SER A C   1 
ATOM   1078 O O   . SER A 1 197 ? -9.657  4.983   17.171  1.00 153.53 ? 217  SER A O   1 
ATOM   1079 C CB  . SER A 1 197 ? -9.833  2.049   15.327  1.00 161.32 ? 217  SER A CB  1 
ATOM   1080 O OG  . SER A 1 197 ? -10.961 2.763   14.857  1.00 172.69 ? 217  SER A OG  1 
ATOM   1081 N N   . VAL A 1 198 ? -8.207  4.490   15.523  1.00 150.38 ? 218  VAL A N   1 
ATOM   1082 C CA  . VAL A 1 198 ? -7.836  5.886   15.330  1.00 170.16 ? 218  VAL A CA  1 
ATOM   1083 C C   . VAL A 1 198 ? -9.053  6.730   14.976  1.00 157.09 ? 218  VAL A C   1 
ATOM   1084 O O   . VAL A 1 198 ? -9.108  7.921   15.306  1.00 180.92 ? 218  VAL A O   1 
ATOM   1085 C CB  . VAL A 1 198 ? -6.736  5.990   14.256  1.00 135.36 ? 218  VAL A CB  1 
ATOM   1086 C CG1 . VAL A 1 198 ? -7.220  5.413   12.930  1.00 193.23 ? 218  VAL A CG1 1 
ATOM   1087 C CG2 . VAL A 1 198 ? -6.291  7.429   14.093  1.00 118.75 ? 218  VAL A CG2 1 
ATOM   1088 N N   . VAL A 1 199 ? -10.044 6.141   14.307  1.00 183.35 ? 219  VAL A N   1 
ATOM   1089 C CA  . VAL A 1 199 ? -11.249 6.859   13.906  1.00 175.07 ? 219  VAL A CA  1 
ATOM   1090 C C   . VAL A 1 199 ? -12.376 6.428   14.834  1.00 166.41 ? 219  VAL A C   1 
ATOM   1091 O O   . VAL A 1 199 ? -13.105 5.467   14.563  1.00 162.07 ? 219  VAL A O   1 
ATOM   1092 C CB  . VAL A 1 199 ? -11.599 6.610   12.430  1.00 147.92 ? 219  VAL A CB  1 
ATOM   1093 C CG1 . VAL A 1 199 ? -10.724 7.468   11.534  1.00 179.80 ? 219  VAL A CG1 1 
ATOM   1094 C CG2 . VAL A 1 199 ? -11.448 5.133   12.077  1.00 122.78 ? 219  VAL A CG2 1 
ATOM   1095 N N   . ARG A 1 200 ? -12.542 7.155   15.928  1.00 181.77 ? 220  ARG A N   1 
ATOM   1096 C CA  . ARG A 1 200 ? -13.609 6.842   16.857  1.00 158.08 ? 220  ARG A CA  1 
ATOM   1097 C C   . ARG A 1 200 ? -14.958 7.210   16.244  1.00 178.49 ? 220  ARG A C   1 
ATOM   1098 O O   . ARG A 1 200 ? -15.048 8.138   15.436  1.00 178.35 ? 220  ARG A O   1 
ATOM   1099 C CB  . ARG A 1 200 ? -13.407 7.588   18.171  1.00 209.59 ? 220  ARG A CB  1 
ATOM   1100 C CG  . ARG A 1 200 ? -12.269 7.035   19.019  1.00 208.54 ? 220  ARG A CG  1 
ATOM   1101 C CD  . ARG A 1 200 ? -11.899 7.969   20.163  1.00 194.97 ? 220  ARG A CD  1 
ATOM   1102 N NE  . ARG A 1 200 ? -10.878 7.388   21.030  1.00 198.31 ? 220  ARG A NE  1 
ATOM   1103 C CZ  . ARG A 1 200 ? -9.583  7.348   20.747  1.00 208.65 ? 220  ARG A CZ  1 
ATOM   1104 N NH1 . ARG A 1 200 ? -9.105  7.843   19.616  1.00 201.97 ? 220  ARG A NH1 1 
ATOM   1105 N NH2 . ARG A 1 200 ? -8.745  6.792   21.617  1.00 197.19 ? 220  ARG A NH2 1 
ATOM   1106 N N   . PRO A 1 201 ? -16.033 6.495   16.614  1.00 165.60 ? 221  PRO A N   1 
ATOM   1107 C CA  . PRO A 1 201 ? -16.095 5.373   17.558  1.00 169.62 ? 221  PRO A CA  1 
ATOM   1108 C C   . PRO A 1 201 ? -15.968 3.984   16.916  1.00 164.87 ? 221  PRO A C   1 
ATOM   1109 O O   . PRO A 1 201 ? -16.744 3.088   17.250  1.00 156.58 ? 221  PRO A O   1 
ATOM   1110 C CB  . PRO A 1 201 ? -17.484 5.540   18.205  1.00 145.00 ? 221  PRO A CB  1 
ATOM   1111 C CG  . PRO A 1 201 ? -18.179 6.663   17.443  1.00 185.99 ? 221  PRO A CG  1 
ATOM   1112 C CD  . PRO A 1 201 ? -17.382 6.918   16.212  1.00 192.71 ? 221  PRO A CD  1 
ATOM   1113 N N   . LEU A 1 202 ? -15.002 3.805   16.016  1.00 163.63 ? 222  LEU A N   1 
ATOM   1114 C CA  . LEU A 1 202 ? -14.788 2.527   15.345  1.00 174.29 ? 222  LEU A CA  1 
ATOM   1115 C C   . LEU A 1 202 ? -13.724 1.723   16.084  1.00 146.21 ? 222  LEU A C   1 
ATOM   1116 O O   . LEU A 1 202 ? -12.650 2.245   16.401  1.00 143.35 ? 222  LEU A O   1 
ATOM   1117 C CB  . LEU A 1 202 ? -14.372 2.745   13.889  1.00 191.48 ? 222  LEU A CB  1 
ATOM   1118 C CG  . LEU A 1 202 ? -15.402 3.449   13.006  1.00 142.66 ? 222  LEU A CG  1 
ATOM   1119 C CD1 . LEU A 1 202 ? -14.769 3.882   11.696  1.00 146.69 ? 222  LEU A CD1 1 
ATOM   1120 C CD2 . LEU A 1 202 ? -16.593 2.540   12.749  1.00 144.70 ? 222  LEU A CD2 1 
ATOM   1121 N N   . ALA A 1 203 ? -14.024 0.453   16.352  1.00 136.50 ? 223  ALA A N   1 
ATOM   1122 C CA  . ALA A 1 203 ? -13.122 -0.399  17.113  1.00 147.26 ? 223  ALA A CA  1 
ATOM   1123 C C   . ALA A 1 203 ? -11.983 -0.905  16.239  1.00 140.78 ? 223  ALA A C   1 
ATOM   1124 O O   . ALA A 1 203 ? -12.113 -1.037  15.019  1.00 146.99 ? 223  ALA A O   1 
ATOM   1125 C CB  . ALA A 1 203 ? -13.878 -1.584  17.715  1.00 157.12 ? 223  ALA A CB  1 
ATOM   1126 N N   . ARG A 1 204 ? -10.854 -1.199  16.885  1.00 119.76 ? 224  ARG A N   1 
ATOM   1127 C CA  . ARG A 1 204 ? -9.684  -1.652  16.145  1.00 122.81 ? 224  ARG A CA  1 
ATOM   1128 C C   . ARG A 1 204 ? -9.937  -2.984  15.450  1.00 119.69 ? 224  ARG A C   1 
ATOM   1129 O O   . ARG A 1 204 ? -9.410  -3.216  14.358  1.00 145.56 ? 224  ARG A O   1 
ATOM   1130 C CB  . ARG A 1 204 ? -8.484  -1.745  17.082  1.00 144.50 ? 224  ARG A CB  1 
ATOM   1131 C CG  . ARG A 1 204 ? -8.005  -0.385  17.560  1.00 151.79 ? 224  ARG A CG  1 
ATOM   1132 C CD  . ARG A 1 204 ? -6.939  -0.497  18.633  1.00 170.61 ? 224  ARG A CD  1 
ATOM   1133 N NE  . ARG A 1 204 ? -5.684  -1.024  18.112  1.00 189.85 ? 224  ARG A NE  1 
ATOM   1134 C CZ  . ARG A 1 204 ? -4.751  -0.294  17.516  1.00 183.67 ? 224  ARG A CZ  1 
ATOM   1135 N NH1 . ARG A 1 204 ? -4.909  1.006   17.319  1.00 177.95 ? 224  ARG A NH1 1 
ATOM   1136 N NH2 . ARG A 1 204 ? -3.630  -0.882  17.106  1.00 172.57 ? 224  ARG A NH2 1 
ATOM   1137 N N   . SER A 1 205 ? -10.745 -3.862  16.049  1.00 128.18 ? 225  SER A N   1 
ATOM   1138 C CA  . SER A 1 205 ? -11.039 -5.144  15.412  1.00 137.15 ? 225  SER A CA  1 
ATOM   1139 C C   . SER A 1 205 ? -11.772 -4.950  14.091  1.00 139.57 ? 225  SER A C   1 
ATOM   1140 O O   . SER A 1 205 ? -11.414 -5.548  13.068  1.00 134.83 ? 225  SER A O   1 
ATOM   1141 C CB  . SER A 1 205 ? -11.870 -6.018  16.352  1.00 151.48 ? 225  SER A CB  1 
ATOM   1142 O OG  . SER A 1 205 ? -12.329 -7.183  15.686  1.00 174.34 ? 225  SER A OG  1 
ATOM   1143 N N   . HIS A 1 206 ? -12.803 -4.108  14.092  1.00 148.63 ? 226  HIS A N   1 
ATOM   1144 C CA  . HIS A 1 206 ? -13.635 -3.966  12.903  1.00 152.35 ? 226  HIS A CA  1 
ATOM   1145 C C   . HIS A 1 206 ? -12.913 -3.183  11.812  1.00 117.57 ? 226  HIS A C   1 
ATOM   1146 O O   . HIS A 1 206 ? -12.982 -3.548  10.632  1.00 128.69 ? 226  HIS A O   1 
ATOM   1147 C CB  . HIS A 1 206 ? -14.959 -3.311  13.290  1.00 167.39 ? 226  HIS A CB  1 
ATOM   1148 C CG  . HIS A 1 206 ? -15.698 -4.053  14.363  1.00 161.43 ? 226  HIS A CG  1 
ATOM   1149 N ND1 . HIS A 1 206 ? -16.507 -3.426  15.286  1.00 170.09 ? 226  HIS A ND1 1 
ATOM   1150 C CD2 . HIS A 1 206 ? -15.743 -5.374  14.660  1.00 172.81 ? 226  HIS A CD2 1 
ATOM   1151 C CE1 . HIS A 1 206 ? -17.020 -4.329  16.104  1.00 198.07 ? 226  HIS A CE1 1 
ATOM   1152 N NE2 . HIS A 1 206 ? -16.572 -5.519  15.746  1.00 170.60 ? 226  HIS A NE2 1 
ATOM   1153 N N   . VAL A 1 207 ? -12.195 -2.120  12.182  1.00 107.41 ? 227  VAL A N   1 
ATOM   1154 C CA  . VAL A 1 207 ? -11.388 -1.418  11.188  1.00 110.88 ? 227  VAL A CA  1 
ATOM   1155 C C   . VAL A 1 207 ? -10.298 -2.335  10.653  1.00 135.99 ? 227  VAL A C   1 
ATOM   1156 O O   . VAL A 1 207 ? -9.911  -2.234  9.486   1.00 144.80 ? 227  VAL A O   1 
ATOM   1157 C CB  . VAL A 1 207 ? -10.786 -0.121  11.765  1.00 124.32 ? 227  VAL A CB  1 
ATOM   1158 C CG1 . VAL A 1 207 ? -11.876 0.773   12.337  1.00 136.37 ? 227  VAL A CG1 1 
ATOM   1159 C CG2 . VAL A 1 207 ? -9.727  -0.442  12.801  1.00 143.09 ? 227  VAL A CG2 1 
ATOM   1160 N N   . ALA A 1 208 ? -9.773  -3.230  11.491  1.00 112.59 ? 228  ALA A N   1 
ATOM   1161 C CA  . ALA A 1 208 ? -8.769  -4.178  11.022  1.00 113.48 ? 228  ALA A CA  1 
ATOM   1162 C C   . ALA A 1 208 ? -9.352  -5.144  10.002  1.00 114.63 ? 228  ALA A C   1 
ATOM   1163 O O   . ALA A 1 208 ? -8.714  -5.446  8.985   1.00 137.46 ? 228  ALA A O   1 
ATOM   1164 C CB  . ALA A 1 208 ? -8.194  -4.947  12.205  1.00 138.48 ? 228  ALA A CB  1 
ATOM   1165 N N   . LEU A 1 209 ? -10.550 -5.661  10.268  1.00 124.14 ? 229  LEU A N   1 
ATOM   1166 C CA  . LEU A 1 209 ? -11.203 -6.515  9.283   1.00 134.80 ? 229  LEU A CA  1 
ATOM   1167 C C   . LEU A 1 209 ? -11.441 -5.749  7.988   1.00 130.51 ? 229  LEU A C   1 
ATOM   1168 O O   . LEU A 1 209 ? -11.215 -6.276  6.892   1.00 146.72 ? 229  LEU A O   1 
ATOM   1169 C CB  . LEU A 1 209 ? -12.515 -7.063  9.845   1.00 138.76 ? 229  LEU A CB  1 
ATOM   1170 C CG  . LEU A 1 209 ? -12.392 -7.927  11.106  1.00 161.11 ? 229  LEU A CG  1 
ATOM   1171 C CD1 . LEU A 1 209 ? -13.702 -8.642  11.404  1.00 164.76 ? 229  LEU A CD1 1 
ATOM   1172 C CD2 . LEU A 1 209 ? -11.254 -8.929  10.982  1.00 171.79 ? 229  LEU A CD2 1 
ATOM   1173 N N   . LEU A 1 210 ? -11.873 -4.491  8.099   1.00 107.64 ? 230  LEU A N   1 
ATOM   1174 C CA  . LEU A 1 210 ? -12.058 -3.663  6.912   1.00 128.78 ? 230  LEU A CA  1 
ATOM   1175 C C   . LEU A 1 210 ? -10.752 -3.497  6.143   1.00 120.21 ? 230  LEU A C   1 
ATOM   1176 O O   . LEU A 1 210 ? -10.734 -3.571  4.911   1.00 158.94 ? 230  LEU A O   1 
ATOM   1177 C CB  . LEU A 1 210 ? -12.625 -2.302  7.318   1.00 113.15 ? 230  LEU A CB  1 
ATOM   1178 C CG  . LEU A 1 210 ? -14.081 -2.321  7.793   1.00 123.08 ? 230  LEU A CG  1 
ATOM   1179 C CD1 . LEU A 1 210 ? -14.570 -0.961  8.268   1.00 109.23 ? 230  LEU A CD1 1 
ATOM   1180 C CD2 . LEU A 1 210 ? -14.977 -2.824  6.680   1.00 164.58 ? 230  LEU A CD2 1 
ATOM   1181 N N   . SER A 1 211 ? -9.648  -3.273  6.856   1.00 112.13 ? 231  SER A N   1 
ATOM   1182 C CA  . SER A 1 211 ? -8.357  -3.075  6.205   1.00 114.57 ? 231  SER A CA  1 
ATOM   1183 C C   . SER A 1 211 ? -7.907  -4.331  5.476   1.00 116.08 ? 231  SER A C   1 
ATOM   1184 O O   . SER A 1 211 ? -7.456  -4.271  4.327   1.00 163.75 ? 231  SER A O   1 
ATOM   1185 C CB  . SER A 1 211 ? -7.310  -2.670  7.243   1.00 132.93 ? 231  SER A CB  1 
ATOM   1186 O OG  . SER A 1 211 ? -6.059  -2.404  6.632   1.00 129.15 ? 231  SER A OG  1 
ATOM   1187 N N   . ALA A 1 212 ? -7.990  -5.480  6.144   1.00 107.41 ? 232  ALA A N   1 
ATOM   1188 C CA  . ALA A 1 212 ? -7.592  -6.726  5.500   1.00 122.32 ? 232  ALA A CA  1 
ATOM   1189 C C   . ALA A 1 212 ? -8.460  -7.004  4.280   1.00 129.89 ? 232  ALA A C   1 
ATOM   1190 O O   . ALA A 1 212 ? -7.956  -7.401  3.216   1.00 128.07 ? 232  ALA A O   1 
ATOM   1191 C CB  . ALA A 1 212 ? -7.675  -7.875  6.503   1.00 120.09 ? 232  ALA A CB  1 
ATOM   1192 N N   . ALA A 1 213 ? -9.771  -6.787  4.412   1.00 107.41 ? 233  ALA A N   1 
ATOM   1193 C CA  . ALA A 1 213 ? -10.664 -6.964  3.278   1.00 107.41 ? 233  ALA A CA  1 
ATOM   1194 C C   . ALA A 1 213 ? -10.272 -6.043  2.135   1.00 126.04 ? 233  ALA A C   1 
ATOM   1195 O O   . ALA A 1 213 ? -10.246 -6.461  0.974   1.00 144.26 ? 233  ALA A O   1 
ATOM   1196 C CB  . ALA A 1 213 ? -12.104 -6.702  3.710   1.00 107.41 ? 233  ALA A CB  1 
ATOM   1197 N N   . PHE A 1 214 ? -9.956  -4.787  2.445   1.00 107.41 ? 234  PHE A N   1 
ATOM   1198 C CA  . PHE A 1 214 ? -9.560  -3.851  1.403   1.00 107.41 ? 234  PHE A CA  1 
ATOM   1199 C C   . PHE A 1 214 ? -8.282  -4.303  0.715   1.00 107.41 ? 234  PHE A C   1 
ATOM   1200 O O   . PHE A 1 214 ? -8.160  -4.202  -0.508  1.00 123.51 ? 234  PHE A O   1 
ATOM   1201 C CB  . PHE A 1 214 ? -9.379  -2.457  1.996   1.00 109.53 ? 234  PHE A CB  1 
ATOM   1202 C CG  . PHE A 1 214 ? -8.596  -1.531  1.117   1.00 125.26 ? 234  PHE A CG  1 
ATOM   1203 C CD1 . PHE A 1 214 ? -9.076  -1.173  -0.130  1.00 143.12 ? 234  PHE A CD1 1 
ATOM   1204 C CD2 . PHE A 1 214 ? -7.381  -1.017  1.534   1.00 126.71 ? 234  PHE A CD2 1 
ATOM   1205 C CE1 . PHE A 1 214 ? -8.360  -0.323  -0.944  1.00 140.57 ? 234  PHE A CE1 1 
ATOM   1206 C CE2 . PHE A 1 214 ? -6.659  -0.163  0.723   1.00 153.83 ? 234  PHE A CE2 1 
ATOM   1207 C CZ  . PHE A 1 214 ? -7.150  0.184   -0.516  1.00 152.24 ? 234  PHE A CZ  1 
ATOM   1208 N N   . PHE A 1 215 ? -7.311  -4.790  1.486   1.00 110.46 ? 235  PHE A N   1 
ATOM   1209 C CA  . PHE A 1 215 ? -6.060  -5.248  0.889   1.00 123.28 ? 235  PHE A CA  1 
ATOM   1210 C C   . PHE A 1 215 ? -6.313  -6.388  -0.085  1.00 107.41 ? 235  PHE A C   1 
ATOM   1211 O O   . PHE A 1 215 ? -5.807  -6.388  -1.215  1.00 146.44 ? 235  PHE A O   1 
ATOM   1212 C CB  . PHE A 1 215 ? -5.088  -5.692  1.982   1.00 120.61 ? 235  PHE A CB  1 
ATOM   1213 C CG  . PHE A 1 215 ? -4.110  -4.633  2.390   1.00 107.41 ? 235  PHE A CG  1 
ATOM   1214 C CD1 . PHE A 1 215 ? -4.429  -3.719  3.376   1.00 107.41 ? 235  PHE A CD1 1 
ATOM   1215 C CD2 . PHE A 1 215 ? -2.867  -4.556  1.792   1.00 107.41 ? 235  PHE A CD2 1 
ATOM   1216 C CE1 . PHE A 1 215 ? -3.529  -2.746  3.753   1.00 107.41 ? 235  PHE A CE1 1 
ATOM   1217 C CE2 . PHE A 1 215 ? -1.964  -3.585  2.165   1.00 107.41 ? 235  PHE A CE2 1 
ATOM   1218 C CZ  . PHE A 1 215 ? -2.296  -2.681  3.148   1.00 107.41 ? 235  PHE A CZ  1 
ATOM   1219 N N   . MET A 1 216 ? -7.102  -7.372  0.339   1.00 107.41 ? 236  MET A N   1 
ATOM   1220 C CA  . MET A 1 216 ? -7.366  -8.513  -0.532  1.00 107.41 ? 236  MET A CA  1 
ATOM   1221 C C   . MET A 1 216 ? -8.173  -8.096  -1.752  1.00 115.63 ? 236  MET A C   1 
ATOM   1222 O O   . MET A 1 216 ? -7.918  -8.563  -2.872  1.00 133.09 ? 236  MET A O   1 
ATOM   1223 C CB  . MET A 1 216 ? -8.089  -9.594  0.254   1.00 130.31 ? 236  MET A CB  1 
ATOM   1224 C CG  . MET A 1 216 ? -7.283  -10.069 1.438   1.00 146.43 ? 236  MET A CG  1 
ATOM   1225 S SD  . MET A 1 216 ? -8.157  -11.259 2.449   1.00 143.38 ? 236  MET A SD  1 
ATOM   1226 C CE  . MET A 1 216 ? -6.863  -12.472 2.661   1.00 146.14 ? 236  MET A CE  1 
ATOM   1227 N N   . VAL A 1 217 ? -9.140  -7.205  -1.553  1.00 118.65 ? 237  VAL A N   1 
ATOM   1228 C CA  . VAL A 1 217 ? -9.926  -6.681  -2.661  1.00 129.89 ? 237  VAL A CA  1 
ATOM   1229 C C   . VAL A 1 217 ? -9.018  -6.001  -3.673  1.00 107.41 ? 237  VAL A C   1 
ATOM   1230 O O   . VAL A 1 217 ? -9.148  -6.198  -4.885  1.00 113.31 ? 237  VAL A O   1 
ATOM   1231 C CB  . VAL A 1 217 ? -10.995 -5.711  -2.129  1.00 138.89 ? 237  VAL A CB  1 
ATOM   1232 C CG1 . VAL A 1 217 ? -11.616 -4.930  -3.267  1.00 137.80 ? 237  VAL A CG1 1 
ATOM   1233 C CG2 . VAL A 1 217 ? -12.054 -6.469  -1.337  1.00 148.64 ? 237  VAL A CG2 1 
ATOM   1234 N N   . PHE A 1 218 ? -8.094  -5.176  -3.186  1.00 107.41 ? 238  PHE A N   1 
ATOM   1235 C CA  . PHE A 1 218 ? -7.193  -4.467  -4.080  1.00 107.41 ? 238  PHE A CA  1 
ATOM   1236 C C   . PHE A 1 218 ? -6.306  -5.440  -4.842  1.00 107.41 ? 238  PHE A C   1 
ATOM   1237 O O   . PHE A 1 218 ? -6.060  -5.260  -6.040  1.00 125.76 ? 238  PHE A O   1 
ATOM   1238 C CB  . PHE A 1 218 ? -6.354  -3.475  -3.283  1.00 107.41 ? 238  PHE A CB  1 
ATOM   1239 C CG  . PHE A 1 218 ? -5.815  -2.350  -4.106  1.00 123.07 ? 238  PHE A CG  1 
ATOM   1240 C CD1 . PHE A 1 218 ? -6.541  -1.183  -4.267  1.00 139.21 ? 238  PHE A CD1 1 
ATOM   1241 C CD2 . PHE A 1 218 ? -4.584  -2.459  -4.726  1.00 119.30 ? 238  PHE A CD2 1 
ATOM   1242 C CE1 . PHE A 1 218 ? -6.046  -0.140  -5.029  1.00 119.41 ? 238  PHE A CE1 1 
ATOM   1243 C CE2 . PHE A 1 218 ? -4.084  -1.421  -5.487  1.00 122.16 ? 238  PHE A CE2 1 
ATOM   1244 C CZ  . PHE A 1 218 ? -4.817  -0.260  -5.638  1.00 107.41 ? 238  PHE A CZ  1 
ATOM   1245 N N   . GLY A 1 219 ? -5.813  -6.476  -4.167  1.00 107.41 ? 239  GLY A N   1 
ATOM   1246 C CA  . GLY A 1 219 ? -5.033  -7.480  -4.871  1.00 107.41 ? 239  GLY A CA  1 
ATOM   1247 C C   . GLY A 1 219 ? -5.821  -8.130  -5.992  1.00 111.22 ? 239  GLY A C   1 
ATOM   1248 O O   . GLY A 1 219 ? -5.311  -8.329  -7.103  1.00 153.50 ? 239  GLY A O   1 
ATOM   1249 N N   . ILE A 1 220 ? -7.084  -8.459  -5.722  1.00 107.41 ? 240  ILE A N   1 
ATOM   1250 C CA  . ILE A 1 220 ? -7.912  -9.083  -6.749  1.00 120.09 ? 240  ILE A CA  1 
ATOM   1251 C C   . ILE A 1 220 ? -8.150  -8.121  -7.906  1.00 123.07 ? 240  ILE A C   1 
ATOM   1252 O O   . ILE A 1 220 ? -8.145  -8.519  -9.078  1.00 115.89 ? 240  ILE A O   1 
ATOM   1253 C CB  . ILE A 1 220 ? -9.235  -9.573  -6.138  1.00 109.29 ? 240  ILE A CB  1 
ATOM   1254 C CG1 . ILE A 1 220 ? -8.952  -10.718 -5.165  1.00 127.12 ? 240  ILE A CG1 1 
ATOM   1255 C CG2 . ILE A 1 220 ? -10.191 -9.992  -7.240  1.00 132.92 ? 240  ILE A CG2 1 
ATOM   1256 C CD1 . ILE A 1 220 ? -10.171 -11.231 -4.433  1.00 147.24 ? 240  ILE A CD1 1 
ATOM   1257 N N   . MET A 1 221 ? -8.388  -6.847  -7.597  1.00 107.41 ? 241  MET A N   1 
ATOM   1258 C CA  . MET A 1 221 ? -8.558  -5.855  -8.651  1.00 108.30 ? 241  MET A CA  1 
ATOM   1259 C C   . MET A 1 221 ? -7.315  -5.779  -9.524  1.00 113.91 ? 241  MET A C   1 
ATOM   1260 O O   . MET A 1 221 ? -7.413  -5.660  -10.751 1.00 132.65 ? 241  MET A O   1 
ATOM   1261 C CB  . MET A 1 221 ? -8.861  -4.489  -8.041  1.00 108.84 ? 241  MET A CB  1 
ATOM   1262 C CG  . MET A 1 221 ? -10.150 -4.443  -7.246  1.00 107.41 ? 241  MET A CG  1 
ATOM   1263 S SD  . MET A 1 221 ? -10.205 -3.069  -6.081  1.00 132.32 ? 241  MET A SD  1 
ATOM   1264 C CE  . MET A 1 221 ? -10.292 -1.680  -7.198  1.00 115.13 ? 241  MET A CE  1 
ATOM   1265 N N   . LEU A 1 222 ? -6.134  -5.838  -8.908  1.00 115.30 ? 242  LEU A N   1 
ATOM   1266 C CA  . LEU A 1 222 ? -4.900  -5.831  -9.685  1.00 113.79 ? 242  LEU A CA  1 
ATOM   1267 C C   . LEU A 1 222 ? -4.828  -7.039  -10.611 1.00 122.39 ? 242  LEU A C   1 
ATOM   1268 O O   . LEU A 1 222 ? -4.469  -6.912  -11.792 1.00 140.22 ? 242  LEU A O   1 
ATOM   1269 C CB  . LEU A 1 222 ? -3.693  -5.801  -8.747  1.00 140.73 ? 242  LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 222 ? -3.547  -4.552  -7.875  1.00 124.48 ? 242  LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 222 ? -2.412  -4.727  -6.881  1.00 136.30 ? 242  LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 222 ? -3.319  -3.319  -8.729  1.00 119.03 ? 242  LEU A CD2 1 
ATOM   1273 N N   . HIS A 1 223 ? -5.168  -8.223  -10.100 1.00 119.05 ? 243  HIS A N   1 
ATOM   1274 C CA  . HIS A 1 223 ? -5.137  -9.395  -10.969 1.00 121.80 ? 243  HIS A CA  1 
ATOM   1275 C C   . HIS A 1 223 ? -6.109  -9.238  -12.131 1.00 133.04 ? 243  HIS A C   1 
ATOM   1276 O O   . HIS A 1 223 ? -5.798  -9.612  -13.269 1.00 139.98 ? 243  HIS A O   1 
ATOM   1277 C CB  . HIS A 1 223 ? -5.463  -10.670 -10.202 1.00 118.77 ? 243  HIS A CB  1 
ATOM   1278 C CG  . HIS A 1 223 ? -5.507  -11.884 -11.078 1.00 124.04 ? 243  HIS A CG  1 
ATOM   1279 N ND1 . HIS A 1 223 ? -6.598  -12.724 -11.141 1.00 132.97 ? 243  HIS A ND1 1 
ATOM   1280 C CD2 . HIS A 1 223 ? -4.601  -12.378 -11.955 1.00 139.79 ? 243  HIS A CD2 1 
ATOM   1281 C CE1 . HIS A 1 223 ? -6.354  -13.695 -12.003 1.00 166.27 ? 243  HIS A CE1 1 
ATOM   1282 N NE2 . HIS A 1 223 ? -5.149  -13.509 -12.511 1.00 157.02 ? 243  HIS A NE2 1 
ATOM   1283 N N   . LEU A 1 224 ? -7.299  -8.703  -11.860 1.00 137.15 ? 244  LEU A N   1 
ATOM   1284 C CA  . LEU A 1 224 ? -8.272  -8.510  -12.930 1.00 140.85 ? 244  LEU A CA  1 
ATOM   1285 C C   . LEU A 1 224 ? -7.764  -7.515  -13.963 1.00 133.21 ? 244  LEU A C   1 
ATOM   1286 O O   . LEU A 1 224 ? -7.987  -7.689  -15.165 1.00 118.51 ? 244  LEU A O   1 
ATOM   1287 C CB  . LEU A 1 224 ? -9.605  -8.044  -12.354 1.00 129.99 ? 244  LEU A CB  1 
ATOM   1288 C CG  . LEU A 1 224 ? -10.604 -9.150  -12.022 1.00 138.13 ? 244  LEU A CG  1 
ATOM   1289 C CD1 . LEU A 1 224 ? -11.868 -8.532  -11.459 1.00 131.49 ? 244  LEU A CD1 1 
ATOM   1290 C CD2 . LEU A 1 224 ? -10.917 -9.998  -13.252 1.00 152.82 ? 244  LEU A CD2 1 
ATOM   1291 N N   . TYR A 1 225 ? -7.093  -6.456  -13.514 1.00 107.41 ? 245  TYR A N   1 
ATOM   1292 C CA  . TYR A 1 225 ? -6.504  -5.513  -14.456 1.00 129.09 ? 245  TYR A CA  1 
ATOM   1293 C C   . TYR A 1 225 ? -5.482  -6.204  -15.349 1.00 131.05 ? 245  TYR A C   1 
ATOM   1294 O O   . TYR A 1 225 ? -5.397  -5.927  -16.553 1.00 123.57 ? 245  TYR A O   1 
ATOM   1295 C CB  . TYR A 1 225 ? -5.858  -4.357  -13.698 1.00 107.41 ? 245  TYR A CB  1 
ATOM   1296 C CG  . TYR A 1 225 ? -5.179  -3.351  -14.592 1.00 125.39 ? 245  TYR A CG  1 
ATOM   1297 C CD1 . TYR A 1 225 ? -5.887  -2.289  -15.137 1.00 141.31 ? 245  TYR A CD1 1 
ATOM   1298 C CD2 . TYR A 1 225 ? -3.828  -3.462  -14.892 1.00 121.47 ? 245  TYR A CD2 1 
ATOM   1299 C CE1 . TYR A 1 225 ? -5.270  -1.364  -15.957 1.00 141.70 ? 245  TYR A CE1 1 
ATOM   1300 C CE2 . TYR A 1 225 ? -3.201  -2.542  -15.710 1.00 151.93 ? 245  TYR A CE2 1 
ATOM   1301 C CZ  . TYR A 1 225 ? -3.926  -1.497  -16.240 1.00 129.69 ? 245  TYR A CZ  1 
ATOM   1302 O OH  . TYR A 1 225 ? -3.301  -0.582  -17.055 1.00 146.22 ? 245  TYR A OH  1 
ATOM   1303 N N   . VAL A 1 226 ? -4.692  -7.110  -14.776 1.00 116.25 ? 246  VAL A N   1 
ATOM   1304 C CA  . VAL A 1 226 ? -3.715  -7.827  -15.589 1.00 107.41 ? 246  VAL A CA  1 
ATOM   1305 C C   . VAL A 1 226 ? -4.412  -8.752  -16.581 1.00 141.82 ? 246  VAL A C   1 
ATOM   1306 O O   . VAL A 1 226 ? -3.965  -8.909  -17.724 1.00 149.20 ? 246  VAL A O   1 
ATOM   1307 C CB  . VAL A 1 226 ? -2.733  -8.589  -14.687 1.00 131.62 ? 246  VAL A CB  1 
ATOM   1308 C CG1 . VAL A 1 226 ? -2.013  -9.669  -15.476 1.00 132.19 ? 246  VAL A CG1 1 
ATOM   1309 C CG2 . VAL A 1 226 ? -1.746  -7.607  -14.081 1.00 163.68 ? 246  VAL A CG2 1 
ATOM   1310 N N   . ARG A 1 227 ? -5.509  -9.385  -16.166 1.00 139.03 ? 247  ARG A N   1 
ATOM   1311 C CA  . ARG A 1 227 ? -6.281  -10.190 -17.110 1.00 130.04 ? 247  ARG A CA  1 
ATOM   1312 C C   . ARG A 1 227 ? -6.809  -9.324  -18.250 1.00 126.98 ? 247  ARG A C   1 
ATOM   1313 O O   . ARG A 1 227 ? -6.799  -9.737  -19.418 1.00 129.62 ? 247  ARG A O   1 
ATOM   1314 C CB  . ARG A 1 227 ? -7.431  -10.896 -16.390 1.00 146.94 ? 247  ARG A CB  1 
ATOM   1315 C CG  . ARG A 1 227 ? -7.000  -11.801 -15.238 1.00 149.02 ? 247  ARG A CG  1 
ATOM   1316 C CD  . ARG A 1 227 ? -6.232  -13.027 -15.709 1.00 145.34 ? 247  ARG A CD  1 
ATOM   1317 N NE  . ARG A 1 227 ? -7.106  -14.055 -16.262 1.00 169.81 ? 247  ARG A NE  1 
ATOM   1318 C CZ  . ARG A 1 227 ? -6.698  -15.258 -16.642 1.00 171.34 ? 247  ARG A CZ  1 
ATOM   1319 N NH1 . ARG A 1 227 ? -5.429  -15.623 -16.539 1.00 168.91 ? 247  ARG A NH1 1 
ATOM   1320 N NH2 . ARG A 1 227 ? -7.584  -16.118 -17.135 1.00 195.98 ? 247  ARG A NH2 1 
ATOM   1321 N N   . ILE A 1 228 ? -7.276  -8.116  -17.923 1.00 129.84 ? 248  ILE A N   1 
ATOM   1322 C CA  . ILE A 1 228 ? -7.717  -7.168  -18.944 1.00 130.15 ? 248  ILE A CA  1 
ATOM   1323 C C   . ILE A 1 228 ? -6.595  -6.914  -19.942 1.00 124.79 ? 248  ILE A C   1 
ATOM   1324 O O   . ILE A 1 228 ? -6.790  -6.962  -21.169 1.00 157.30 ? 248  ILE A O   1 
ATOM   1325 C CB  . ILE A 1 228 ? -8.174  -5.853  -18.283 1.00 112.42 ? 248  ILE A CB  1 
ATOM   1326 C CG1 . ILE A 1 228 ? -9.504  -6.046  -17.548 1.00 121.83 ? 248  ILE A CG1 1 
ATOM   1327 C CG2 . ILE A 1 228 ? -8.260  -4.735  -19.320 1.00 126.27 ? 248  ILE A CG2 1 
ATOM   1328 C CD1 . ILE A 1 228 ? -9.944  -4.837  -16.727 1.00 107.41 ? 248  ILE A CD1 1 
ATOM   1329 N N   . CYS A 1 229 ? -5.404  -6.619  -19.426 1.00 119.85 ? 249  CYS A N   1 
ATOM   1330 C CA  . CYS A 1 229 ? -4.274  -6.384  -20.313 1.00 126.58 ? 249  CYS A CA  1 
ATOM   1331 C C   . CYS A 1 229 ? -4.052  -7.584  -21.220 1.00 115.08 ? 249  CYS A C   1 
ATOM   1332 O O   . CYS A 1 229 ? -3.902  -7.428  -22.433 1.00 133.44 ? 249  CYS A O   1 
ATOM   1333 C CB  . CYS A 1 229 ? -3.019  -6.070  -19.505 1.00 141.66 ? 249  CYS A CB  1 
ATOM   1334 S SG  . CYS A 1 229 ? -2.972  -4.372  -18.900 1.00 125.67 ? 249  CYS A SG  1 
ATOM   1335 N N   . GLN A 1 230 ? -4.040  -8.791  -20.646 1.00 125.68 ? 250  GLN A N   1 
ATOM   1336 C CA  . GLN A 1 230 ? -3.867  -9.999  -21.449 1.00 124.25 ? 250  GLN A CA  1 
ATOM   1337 C C   . GLN A 1 230 ? -4.871  -10.045 -22.589 1.00 137.73 ? 250  GLN A C   1 
ATOM   1338 O O   . GLN A 1 230 ? -4.528  -10.384 -23.731 1.00 140.81 ? 250  GLN A O   1 
ATOM   1339 C CB  . GLN A 1 230 ? -4.038  -11.241 -20.576 1.00 139.15 ? 250  GLN A CB  1 
ATOM   1340 C CG  . GLN A 1 230 ? -3.012  -11.405 -19.482 1.00 131.60 ? 250  GLN A CG  1 
ATOM   1341 C CD  . GLN A 1 230 ? -3.368  -12.535 -18.538 1.00 136.83 ? 250  GLN A CD  1 
ATOM   1342 O OE1 . GLN A 1 230 ? -4.444  -13.126 -18.637 1.00 110.14 ? 250  GLN A OE1 1 
ATOM   1343 N NE2 . GLN A 1 230 ? -2.466  -12.843 -17.617 1.00 177.46 ? 250  GLN A NE2 1 
ATOM   1344 N N   . VAL A 1 231 ? -6.128  -9.728  -22.283 1.00 139.84 ? 251  VAL A N   1 
ATOM   1345 C CA  . VAL A 1 231 ? -7.174  -9.762  -23.299 1.00 147.25 ? 251  VAL A CA  1 
ATOM   1346 C C   . VAL A 1 231 ? -6.826  -8.821  -24.443 1.00 140.27 ? 251  VAL A C   1 
ATOM   1347 O O   . VAL A 1 231 ? -6.945  -9.174  -25.623 1.00 151.30 ? 251  VAL A O   1 
ATOM   1348 C CB  . VAL A 1 231 ? -8.534  -9.407  -22.675 1.00 161.27 ? 251  VAL A CB  1 
ATOM   1349 C CG1 . VAL A 1 231 ? -9.536  -9.029  -23.757 1.00 174.76 ? 251  VAL A CG1 1 
ATOM   1350 C CG2 . VAL A 1 231 ? -9.049  -10.568 -21.837 1.00 149.41 ? 251  VAL A CG2 1 
ATOM   1351 N N   . VAL A 1 232 ? -6.402  -7.603  -24.111 1.00 125.90 ? 252  VAL A N   1 
ATOM   1352 C CA  . VAL A 1 232 ? -6.086  -6.643  -25.168 1.00 132.73 ? 252  VAL A CA  1 
ATOM   1353 C C   . VAL A 1 232 ? -4.861  -7.100  -25.960 1.00 145.73 ? 252  VAL A C   1 
ATOM   1354 O O   . VAL A 1 232 ? -4.803  -6.950  -27.190 1.00 148.04 ? 252  VAL A O   1 
ATOM   1355 C CB  . VAL A 1 232 ? -5.893  -5.236  -24.579 1.00 126.72 ? 252  VAL A CB  1 
ATOM   1356 C CG1 . VAL A 1 232 ? -5.617  -4.231  -25.688 1.00 173.15 ? 252  VAL A CG1 1 
ATOM   1357 C CG2 . VAL A 1 232 ? -7.123  -4.827  -23.782 1.00 149.41 ? 252  VAL A CG2 1 
ATOM   1358 N N   . TRP A 1 233 ? -3.860  -7.649  -25.269 1.00 148.35 ? 253  TRP A N   1 
ATOM   1359 C CA  . TRP A 1 233 ? -2.695  -8.192  -25.956 1.00 156.25 ? 253  TRP A CA  1 
ATOM   1360 C C   . TRP A 1 233 ? -3.133  -9.189  -27.015 1.00 161.28 ? 253  TRP A C   1 
ATOM   1361 O O   . TRP A 1 233 ? -2.670  -9.147  -28.158 1.00 188.03 ? 253  TRP A O   1 
ATOM   1362 C CB  . TRP A 1 233 ? -1.744  -8.878  -24.971 1.00 185.86 ? 253  TRP A CB  1 
ATOM   1363 C CG  . TRP A 1 233 ? -0.977  -7.965  -24.062 1.00 177.44 ? 253  TRP A CG  1 
ATOM   1364 C CD1 . TRP A 1 233 ? -1.246  -7.705  -22.754 1.00 172.10 ? 253  TRP A CD1 1 
ATOM   1365 C CD2 . TRP A 1 233 ? 0.201   -7.214  -24.384 1.00 203.48 ? 253  TRP A CD2 1 
ATOM   1366 N NE1 . TRP A 1 233 ? -0.326  -6.830  -22.240 1.00 184.58 ? 253  TRP A NE1 1 
ATOM   1367 C CE2 . TRP A 1 233 ? 0.576   -6.513  -23.220 1.00 218.46 ? 253  TRP A CE2 1 
ATOM   1368 C CE3 . TRP A 1 233 ? 0.972   -7.062  -25.541 1.00 195.72 ? 253  TRP A CE3 1 
ATOM   1369 C CZ2 . TRP A 1 233 ? 1.685   -5.672  -23.178 1.00 208.02 ? 253  TRP A CZ2 1 
ATOM   1370 C CZ3 . TRP A 1 233 ? 2.075   -6.225  -25.499 1.00 205.70 ? 253  TRP A CZ3 1 
ATOM   1371 C CH2 . TRP A 1 233 ? 2.420   -5.541  -24.325 1.00 195.78 ? 253  TRP A CH2 1 
ATOM   1372 N N   . ARG A 1 234 ? -4.029  -10.103 -26.640 1.00 154.77 ? 254  ARG A N   1 
ATOM   1373 C CA  . ARG A 1 234 ? -4.482  -11.114 -27.590 1.00 183.40 ? 254  ARG A CA  1 
ATOM   1374 C C   . ARG A 1 234 ? -5.298  -10.497 -28.718 1.00 179.28 ? 254  ARG A C   1 
ATOM   1375 O O   . ARG A 1 234 ? -5.173  -10.910 -29.877 1.00 182.59 ? 254  ARG A O   1 
ATOM   1376 C CB  . ARG A 1 234 ? -5.301  -12.182 -26.874 1.00 193.32 ? 254  ARG A CB  1 
ATOM   1377 C CG  . ARG A 1 234 ? -4.474  -13.116 -26.019 1.00 198.46 ? 254  ARG A CG  1 
ATOM   1378 C CD  . ARG A 1 234 ? -5.334  -14.248 -25.496 1.00 206.05 ? 254  ARG A CD  1 
ATOM   1379 N NE  . ARG A 1 234 ? -5.698  -15.183 -26.554 1.00 211.71 ? 254  ARG A NE  1 
ATOM   1380 C CZ  . ARG A 1 234 ? -6.756  -15.983 -26.522 1.00 204.92 ? 254  ARG A CZ  1 
ATOM   1381 N NH1 . ARG A 1 234 ? -7.616  -15.955 -25.516 1.00 211.48 ? 254  ARG A NH1 1 
ATOM   1382 N NH2 . ARG A 1 234 ? -6.961  -16.828 -27.528 1.00 191.17 ? 254  ARG A NH2 1 
ATOM   1383 N N   . HIS A 1 235 ? -6.159  -9.528  -28.403 1.00 152.16 ? 255  HIS A N   1 
ATOM   1384 C CA  . HIS A 1 235 ? -6.948  -8.897  -29.455 1.00 148.89 ? 255  HIS A CA  1 
ATOM   1385 C C   . HIS A 1 235 ? -6.042  -8.260  -30.499 1.00 152.34 ? 255  HIS A C   1 
ATOM   1386 O O   . HIS A 1 235 ? -6.342  -8.295  -31.696 1.00 174.67 ? 255  HIS A O   1 
ATOM   1387 C CB  . HIS A 1 235 ? -7.900  -7.859  -28.862 1.00 160.59 ? 255  HIS A CB  1 
ATOM   1388 C CG  . HIS A 1 235 ? -9.131  -8.452  -28.249 1.00 172.59 ? 255  HIS A CG  1 
ATOM   1389 N ND1 . HIS A 1 235 ? -9.278  -9.806  -28.038 1.00 177.00 ? 255  HIS A ND1 1 
ATOM   1390 C CD2 . HIS A 1 235 ? -10.274 -7.876  -27.807 1.00 164.87 ? 255  HIS A CD2 1 
ATOM   1391 C CE1 . HIS A 1 235 ? -10.457 -10.039 -27.489 1.00 173.58 ? 255  HIS A CE1 1 
ATOM   1392 N NE2 . HIS A 1 235 ? -11.082 -8.885  -27.338 1.00 154.20 ? 255  HIS A NE2 1 
ATOM   1393 N N   . ALA A 1 236 ? -4.925  -7.674  -30.064 1.00 175.61 ? 256  ALA A N   1 
ATOM   1394 C CA  . ALA A 1 236 ? -3.983  -7.098  -31.021 1.00 164.17 ? 256  ALA A CA  1 
ATOM   1395 C C   . ALA A 1 236 ? -3.183  -8.178  -31.749 1.00 172.88 ? 256  ALA A C   1 
ATOM   1396 O O   . ALA A 1 236 ? -2.923  -8.062  -32.954 1.00 161.82 ? 256  ALA A O   1 
ATOM   1397 C CB  . ALA A 1 236 ? -3.043  -6.127  -30.309 1.00 166.14 ? 256  ALA A CB  1 
ATOM   1398 N N   A ALA A 1 237 ? -2.786  -9.234  -31.037 0.49 231.35 ? 1001 ALA A N   1 
ATOM   1399 N N   B ALA A 1 237 ? -2.785  -9.234  -31.037 0.51 232.18 ? 1001 ALA A N   1 
ATOM   1400 C CA  A ALA A 1 237 ? -1.922  -10.248 -31.634 0.49 228.14 ? 1001 ALA A CA  1 
ATOM   1401 C CA  B ALA A 1 237 ? -1.921  -10.248 -31.634 0.51 222.37 ? 1001 ALA A CA  1 
ATOM   1402 C C   A ALA A 1 237 ? -2.655  -11.050 -32.700 0.49 192.63 ? 1001 ALA A C   1 
ATOM   1403 C C   B ALA A 1 237 ? -2.655  -11.050 -32.700 0.51 188.54 ? 1001 ALA A C   1 
ATOM   1404 O O   A ALA A 1 237 ? -2.097  -11.335 -33.768 0.49 208.36 ? 1001 ALA A O   1 
ATOM   1405 O O   B ALA A 1 237 ? -2.097  -11.335 -33.767 0.51 208.78 ? 1001 ALA A O   1 
ATOM   1406 C CB  A ALA A 1 237 ? -1.380  -11.174 -30.546 0.49 194.82 ? 1001 ALA A CB  1 
ATOM   1407 C CB  B ALA A 1 237 ? -1.380  -11.174 -30.546 0.51 201.25 ? 1001 ALA A CB  1 
ATOM   1408 N N   . ASP A 1 238 ? -3.901  -11.438 -32.426 1.00 171.88 ? 1002 ASP A N   1 
ATOM   1409 C CA  . ASP A 1 238 ? -4.675  -12.170 -33.420 1.00 194.74 ? 1002 ASP A CA  1 
ATOM   1410 C C   . ASP A 1 238 ? -4.929  -11.303 -34.645 1.00 188.78 ? 1002 ASP A C   1 
ATOM   1411 O O   . ASP A 1 238 ? -4.913  -11.794 -35.780 1.00 203.60 ? 1002 ASP A O   1 
ATOM   1412 C CB  . ASP A 1 238 ? -5.986  -12.657 -32.803 1.00 191.88 ? 1002 ASP A CB  1 
ATOM   1413 C CG  . ASP A 1 238 ? -5.768  -13.698 -31.716 1.00 197.71 ? 1002 ASP A CG  1 
ATOM   1414 O OD1 . ASP A 1 238 ? -4.619  -14.163 -31.555 1.00 187.65 ? 1002 ASP A OD1 1 
ATOM   1415 O OD2 . ASP A 1 238 ? -6.743  -14.049 -31.018 1.00 159.16 ? 1002 ASP A OD2 1 
ATOM   1416 N N   . LEU A 1 239 ? -5.155  -10.004 -34.434 1.00 209.54 ? 1003 LEU A N   1 
ATOM   1417 C CA  . LEU A 1 239 ? -5.310  -9.086  -35.558 1.00 203.43 ? 1003 LEU A CA  1 
ATOM   1418 C C   . LEU A 1 239 ? -4.037  -9.014  -36.397 1.00 179.80 ? 1003 LEU A C   1 
ATOM   1419 O O   . LEU A 1 239 ? -4.098  -8.988  -37.631 1.00 158.08 ? 1003 LEU A O   1 
ATOM   1420 C CB  . LEU A 1 239 ? -5.700  -7.697  -35.046 1.00 171.64 ? 1003 LEU A CB  1 
ATOM   1421 C CG  . LEU A 1 239 ? -7.186  -7.316  -35.097 1.00 132.17 ? 1003 LEU A CG  1 
ATOM   1422 C CD1 . LEU A 1 239 ? -8.067  -8.280  -34.305 1.00 142.62 ? 1003 LEU A CD1 1 
ATOM   1423 C CD2 . LEU A 1 239 ? -7.385  -5.887  -34.596 1.00 129.16 ? 1003 LEU A CD2 1 
ATOM   1424 N N   . GLU A 1 240 ? -2.872  -8.966  -35.747 1.00 216.58 ? 1004 GLU A N   1 
ATOM   1425 C CA  . GLU A 1 240 ? -1.617  -8.962  -36.497 1.00 150.81 ? 1004 GLU A CA  1 
ATOM   1426 C C   . GLU A 1 240 ? -1.447  -10.256 -37.288 1.00 187.38 ? 1004 GLU A C   1 
ATOM   1427 O O   . GLU A 1 240 ? -1.001  -10.239 -38.444 1.00 170.68 ? 1004 GLU A O   1 
ATOM   1428 C CB  . GLU A 1 240 ? -0.438  -8.754  -35.547 1.00 172.88 ? 1004 GLU A CB  1 
ATOM   1429 N N   . ASP A 1 241 ? -1.795  -11.391 -36.676 1.00 176.86 ? 1005 ASP A N   1 
ATOM   1430 C CA  . ASP A 1 241 ? -1.727  -12.662 -37.395 1.00 183.22 ? 1005 ASP A CA  1 
ATOM   1431 C C   . ASP A 1 241 ? -2.645  -12.648 -38.611 1.00 178.78 ? 1005 ASP A C   1 
ATOM   1432 O O   . ASP A 1 241 ? -2.275  -13.125 -39.692 1.00 183.45 ? 1005 ASP A O   1 
ATOM   1433 C CB  . ASP A 1 241 ? -2.101  -13.820 -36.470 1.00 188.65 ? 1005 ASP A CB  1 
ATOM   1434 C CG  . ASP A 1 241 ? -2.133  -15.157 -37.194 1.00 195.36 ? 1005 ASP A CG  1 
ATOM   1435 O OD1 . ASP A 1 241 ? -1.066  -15.609 -37.661 1.00 214.27 ? 1005 ASP A OD1 1 
ATOM   1436 O OD2 . ASP A 1 241 ? -3.226  -15.753 -37.300 1.00 209.85 ? 1005 ASP A OD2 1 
ATOM   1437 N N   . ASN A 1 242 ? -3.855  -12.110 -38.446 1.00 157.27 ? 1006 ASN A N   1 
ATOM   1438 C CA  . ASN A 1 242 ? -4.800  -12.059 -39.553 1.00 167.48 ? 1006 ASN A CA  1 
ATOM   1439 C C   . ASN A 1 242 ? -4.312  -11.128 -40.656 1.00 164.22 ? 1006 ASN A C   1 
ATOM   1440 O O   . ASN A 1 242 ? -4.517  -11.407 -41.838 1.00 173.94 ? 1006 ASN A O   1 
ATOM   1441 C CB  . ASN A 1 242 ? -6.175  -11.630 -39.046 1.00 187.99 ? 1006 ASN A CB  1 
ATOM   1442 C CG  . ASN A 1 242 ? -6.819  -12.678 -38.157 1.00 200.20 ? 1006 ASN A CG  1 
ATOM   1443 O OD1 . ASN A 1 242 ? -7.110  -12.423 -36.989 1.00 202.99 ? 1006 ASN A OD1 1 
ATOM   1444 N ND2 . ASN A 1 242 ? -7.044  -13.866 -38.708 1.00 199.87 ? 1006 ASN A ND2 1 
ATOM   1445 N N   . TRP A 1 243 ? -3.676  -10.012 -40.295 1.00 195.98 ? 1007 TRP A N   1 
ATOM   1446 C CA  . TRP A 1 243 ? -3.088  -9.146  -41.314 1.00 158.86 ? 1007 TRP A CA  1 
ATOM   1447 C C   . TRP A 1 243 ? -1.996  -9.877  -42.082 1.00 185.50 ? 1007 TRP A C   1 
ATOM   1448 O O   . TRP A 1 243 ? -1.929  -9.788  -43.314 1.00 156.82 ? 1007 TRP A O   1 
ATOM   1449 C CB  . TRP A 1 243 ? -2.537  -7.871  -40.672 1.00 187.90 ? 1007 TRP A CB  1 
ATOM   1450 C CG  . TRP A 1 243 ? -1.577  -7.091  -41.544 1.00 193.74 ? 1007 TRP A CG  1 
ATOM   1451 C CD1 . TRP A 1 243 ? -0.237  -7.320  -41.701 1.00 207.34 ? 1007 TRP A CD1 1 
ATOM   1452 C CD2 . TRP A 1 243 ? -1.884  -5.950  -42.359 1.00 197.50 ? 1007 TRP A CD2 1 
ATOM   1453 N NE1 . TRP A 1 243 ? 0.304   -6.401  -42.567 1.00 202.52 ? 1007 TRP A NE1 1 
ATOM   1454 C CE2 . TRP A 1 243 ? -0.684  -5.548  -42.985 1.00 210.28 ? 1007 TRP A CE2 1 
ATOM   1455 C CE3 . TRP A 1 243 ? -3.054  -5.233  -42.623 1.00 162.09 ? 1007 TRP A CE3 1 
ATOM   1456 C CZ2 . TRP A 1 243 ? -0.623  -4.461  -43.856 1.00 178.99 ? 1007 TRP A CZ2 1 
ATOM   1457 C CZ3 . TRP A 1 243 ? -2.990  -4.153  -43.490 1.00 180.34 ? 1007 TRP A CZ3 1 
ATOM   1458 C CH2 . TRP A 1 243 ? -1.784  -3.779  -44.096 1.00 177.09 ? 1007 TRP A CH2 1 
ATOM   1459 N N   . GLU A 1 244 ? -1.128  -10.605 -41.374 1.00 154.70 ? 1008 GLU A N   1 
ATOM   1460 C CA  . GLU A 1 244 ? -0.103  -11.383 -42.065 1.00 154.06 ? 1008 GLU A CA  1 
ATOM   1461 C C   . GLU A 1 244 ? -0.741  -12.363 -43.039 1.00 168.51 ? 1008 GLU A C   1 
ATOM   1462 O O   . GLU A 1 244 ? -0.346  -12.445 -44.208 1.00 191.27 ? 1008 GLU A O   1 
ATOM   1463 C CB  . GLU A 1 244 ? 0.778   -12.133 -41.064 1.00 198.80 ? 1008 GLU A CB  1 
ATOM   1464 C CG  . GLU A 1 244 ? 1.947   -11.325 -40.520 1.00 206.93 ? 1008 GLU A CG  1 
ATOM   1465 C CD  . GLU A 1 244 ? 3.095   -12.200 -40.040 1.00 189.82 ? 1008 GLU A CD  1 
ATOM   1466 O OE1 . GLU A 1 244 ? 3.094   -13.413 -40.338 1.00 166.63 ? 1008 GLU A OE1 1 
ATOM   1467 O OE2 . GLU A 1 244 ? 4.004   -11.672 -39.367 1.00 176.46 ? 1008 GLU A OE2 1 
ATOM   1468 N N   . THR A 1 245 ? -1.744  -13.108 -42.573 1.00 148.99 ? 1009 THR A N   1 
ATOM   1469 C CA  . THR A 1 245 ? -2.375  -14.108 -43.429 1.00 195.52 ? 1009 THR A CA  1 
ATOM   1470 C C   . THR A 1 245 ? -3.099  -13.460 -44.604 1.00 163.19 ? 1009 THR A C   1 
ATOM   1471 O O   . THR A 1 245 ? -3.053  -13.977 -45.722 1.00 185.52 ? 1009 THR A O   1 
ATOM   1472 C CB  . THR A 1 245 ? -3.340  -14.968 -42.615 1.00 171.71 ? 1009 THR A CB  1 
ATOM   1473 O OG1 . THR A 1 245 ? -4.313  -14.130 -41.982 1.00 169.64 ? 1009 THR A OG1 1 
ATOM   1474 C CG2 . THR A 1 245 ? -2.584  -15.768 -41.560 1.00 176.24 ? 1009 THR A CG2 1 
ATOM   1475 N N   . LEU A 1 246 ? -3.772  -12.331 -44.374 1.00 197.37 ? 1010 LEU A N   1 
ATOM   1476 C CA  . LEU A 1 246 ? -4.521  -11.671 -45.440 1.00 201.89 ? 1010 LEU A CA  1 
ATOM   1477 C C   . LEU A 1 246 ? -3.591  -11.103 -46.504 1.00 190.00 ? 1010 LEU A C   1 
ATOM   1478 O O   . LEU A 1 246 ? -3.864  -11.225 -47.704 1.00 182.35 ? 1010 LEU A O   1 
ATOM   1479 C CB  . LEU A 1 246 ? -5.400  -10.569 -44.843 1.00 155.06 ? 1010 LEU A CB  1 
ATOM   1480 C CG  . LEU A 1 246 ? -6.347  -9.818  -45.782 1.00 164.49 ? 1010 LEU A CG  1 
ATOM   1481 C CD1 . LEU A 1 246 ? -7.597  -9.381  -45.031 1.00 129.14 ? 1010 LEU A CD1 1 
ATOM   1482 C CD2 . LEU A 1 246 ? -5.664  -8.609  -46.411 1.00 168.82 ? 1010 LEU A CD2 1 
ATOM   1483 N N   . ASN A 1 247 ? -2.493  -10.467 -46.092 1.00 156.63 ? 1011 ASN A N   1 
ATOM   1484 C CA  . ASN A 1 247 ? -1.530  -9.976  -47.071 1.00 188.53 ? 1011 ASN A CA  1 
ATOM   1485 C C   . ASN A 1 247 ? -0.862  -11.128 -47.808 1.00 167.22 ? 1011 ASN A C   1 
ATOM   1486 O O   . ASN A 1 247 ? -0.622  -11.039 -49.017 1.00 181.72 ? 1011 ASN A O   1 
ATOM   1487 C CB  . ASN A 1 247 ? -0.490  -9.090  -46.391 1.00 160.28 ? 1011 ASN A CB  1 
ATOM   1488 C CG  . ASN A 1 247 ? -0.985  -7.674  -46.185 1.00 187.69 ? 1011 ASN A CG  1 
ATOM   1489 O OD1 . ASN A 1 247 ? -2.190  -7.419  -46.204 1.00 175.60 ? 1011 ASN A OD1 1 
ATOM   1490 N ND2 . ASN A 1 247 ? -0.058  -6.743  -45.997 1.00 177.91 ? 1011 ASN A ND2 1 
ATOM   1491 N N   . ASP A 1 248 ? -0.562  -12.223 -47.105 1.00 152.29 ? 1012 ASP A N   1 
ATOM   1492 C CA  . ASP A 1 248 ? -0.017  -13.395 -47.780 1.00 213.85 ? 1012 ASP A CA  1 
ATOM   1493 C C   . ASP A 1 248 ? -1.006  -13.946 -48.801 1.00 201.22 ? 1012 ASP A C   1 
ATOM   1494 O O   . ASP A 1 248 ? -0.610  -14.365 -49.893 1.00 170.93 ? 1012 ASP A O   1 
ATOM   1495 C CB  . ASP A 1 248 ? 0.353   -14.466 -46.752 1.00 192.15 ? 1012 ASP A CB  1 
ATOM   1496 C CG  . ASP A 1 248 ? 1.475   -14.025 -45.826 1.00 198.94 ? 1012 ASP A CG  1 
ATOM   1497 O OD1 . ASP A 1 248 ? 2.002   -12.910 -46.021 1.00 190.40 ? 1012 ASP A OD1 1 
ATOM   1498 O OD2 . ASP A 1 248 ? 1.829   -14.790 -44.901 1.00 151.29 ? 1012 ASP A OD2 1 
ATOM   1499 N N   . ASN A 1 249 ? -2.298  -13.948 -48.465 1.00 188.80 ? 1013 ASN A N   1 
ATOM   1500 C CA  . ASN A 1 249 ? -3.312  -14.440 -49.394 1.00 194.62 ? 1013 ASN A CA  1 
ATOM   1501 C C   . ASN A 1 249 ? -3.431  -13.534 -50.613 1.00 172.94 ? 1013 ASN A C   1 
ATOM   1502 O O   . ASN A 1 249 ? -3.511  -14.014 -51.748 1.00 167.96 ? 1013 ASN A O   1 
ATOM   1503 C CB  . ASN A 1 249 ? -4.663  -14.558 -48.690 1.00 196.08 ? 1013 ASN A CB  1 
ATOM   1504 C CG  . ASN A 1 249 ? -4.713  -15.717 -47.723 1.00 185.22 ? 1013 ASN A CG  1 
ATOM   1505 O OD1 . ASN A 1 249 ? -3.978  -16.695 -47.869 1.00 177.31 ? 1013 ASN A OD1 1 
ATOM   1506 N ND2 . ASN A 1 249 ? -5.585  -15.618 -46.726 1.00 210.02 ? 1013 ASN A ND2 1 
ATOM   1507 N N   . LEU A 1 250 ? -3.462  -12.219 -50.400 1.00 169.98 ? 1014 LEU A N   1 
ATOM   1508 C CA  . LEU A 1 250 ? -3.521  -11.303 -51.534 1.00 152.84 ? 1014 LEU A CA  1 
ATOM   1509 C C   . LEU A 1 250 ? -2.287  -11.449 -52.413 1.00 156.12 ? 1014 LEU A C   1 
ATOM   1510 O O   . LEU A 1 250 ? -2.379  -11.370 -53.644 1.00 196.93 ? 1014 LEU A O   1 
ATOM   1511 C CB  . LEU A 1 250 ? -3.667  -9.862  -51.047 1.00 163.72 ? 1014 LEU A CB  1 
ATOM   1512 C CG  . LEU A 1 250 ? -5.098  -9.397  -50.773 1.00 193.13 ? 1014 LEU A CG  1 
ATOM   1513 C CD1 . LEU A 1 250 ? -5.093  -8.107  -49.970 1.00 185.75 ? 1014 LEU A CD1 1 
ATOM   1514 C CD2 . LEU A 1 250 ? -5.859  -9.208  -52.076 1.00 183.49 ? 1014 LEU A CD2 1 
ATOM   1515 N N   . LYS A 1 251 ? -1.120  -11.662 -51.801 1.00 173.46 ? 1015 LYS A N   1 
ATOM   1516 C CA  . LYS A 1 251 ? 0.097   -11.862 -52.578 1.00 185.06 ? 1015 LYS A CA  1 
ATOM   1517 C C   . LYS A 1 251 ? 0.026   -13.150 -53.390 1.00 158.29 ? 1015 LYS A C   1 
ATOM   1518 O O   . LYS A 1 251 ? 0.345   -13.160 -54.583 1.00 197.67 ? 1015 LYS A O   1 
ATOM   1519 C CB  . LYS A 1 251 ? 1.312   -11.875 -51.648 1.00 145.65 ? 1015 LYS A CB  1 
ATOM   1520 N N   . VAL A 1 252 ? -0.401  -14.250 -52.762 1.00 186.26 ? 1016 VAL A N   1 
ATOM   1521 C CA  . VAL A 1 252 ? -0.412  -15.537 -53.447 1.00 171.56 ? 1016 VAL A CA  1 
ATOM   1522 C C   . VAL A 1 252 ? -1.545  -15.634 -54.462 1.00 175.61 ? 1016 VAL A C   1 
ATOM   1523 O O   . VAL A 1 252 ? -1.499  -16.494 -55.349 1.00 188.48 ? 1016 VAL A O   1 
ATOM   1524 C CB  . VAL A 1 252 ? -0.501  -16.699 -52.437 1.00 203.00 ? 1016 VAL A CB  1 
ATOM   1525 C CG1 . VAL A 1 252 ? 0.674   -16.661 -51.460 1.00 198.57 ? 1016 VAL A CG1 1 
ATOM   1526 C CG2 . VAL A 1 252 ? -1.825  -16.666 -51.698 1.00 212.89 ? 1016 VAL A CG2 1 
ATOM   1527 N N   . ILE A 1 253 ? -2.571  -14.786 -54.356 1.00 183.94 ? 1017 ILE A N   1 
ATOM   1528 C CA  . ILE A 1 253 ? -3.621  -14.763 -55.373 1.00 185.47 ? 1017 ILE A CA  1 
ATOM   1529 C C   . ILE A 1 253 ? -3.041  -14.347 -56.719 1.00 188.89 ? 1017 ILE A C   1 
ATOM   1530 O O   . ILE A 1 253 ? -3.330  -14.952 -57.758 1.00 192.11 ? 1017 ILE A O   1 
ATOM   1531 C CB  . ILE A 1 253 ? -4.766  -13.824 -54.949 1.00 181.25 ? 1017 ILE A CB  1 
ATOM   1532 C CG1 . ILE A 1 253 ? -5.653  -14.498 -53.900 1.00 169.31 ? 1017 ILE A CG1 1 
ATOM   1533 C CG2 . ILE A 1 253 ? -5.595  -13.410 -56.163 1.00 149.19 ? 1017 ILE A CG2 1 
ATOM   1534 C CD1 . ILE A 1 253 ? -6.643  -13.559 -53.237 1.00 167.73 ? 1017 ILE A CD1 1 
ATOM   1535 N N   . GLU A 1 254 ? -2.208  -13.306 -56.715 1.00 174.07 ? 1018 GLU A N   1 
ATOM   1536 C CA  . GLU A 1 254 ? -1.682  -12.767 -57.964 1.00 172.66 ? 1018 GLU A CA  1 
ATOM   1537 C C   . GLU A 1 254 ? -0.833  -13.798 -58.698 1.00 166.76 ? 1018 GLU A C   1 
ATOM   1538 O O   . GLU A 1 254 ? -0.860  -13.870 -59.932 1.00 200.23 ? 1018 GLU A O   1 
ATOM   1539 C CB  . GLU A 1 254 ? -0.871  -11.504 -57.673 1.00 174.21 ? 1018 GLU A CB  1 
ATOM   1540 C CG  . GLU A 1 254 ? -1.665  -10.419 -56.947 1.00 178.84 ? 1018 GLU A CG  1 
ATOM   1541 C CD  . GLU A 1 254 ? -0.784  -9.466  -56.154 1.00 185.95 ? 1018 GLU A CD  1 
ATOM   1542 O OE1 . GLU A 1 254 ? 0.455   -9.616  -56.195 1.00 178.35 ? 1018 GLU A OE1 1 
ATOM   1543 O OE2 . GLU A 1 254 ? -1.334  -8.567  -55.483 1.00 163.73 ? 1018 GLU A OE2 1 
ATOM   1544 N N   . LYS A 1 255 ? -0.072  -14.604 -57.958 1.00 173.26 ? 1019 LYS A N   1 
ATOM   1545 C CA  . LYS A 1 255 ? 0.825   -15.594 -58.549 1.00 173.66 ? 1019 LYS A CA  1 
ATOM   1546 C C   . LYS A 1 255 ? 0.158   -16.967 -58.521 1.00 194.37 ? 1019 LYS A C   1 
ATOM   1547 O O   . LYS A 1 255 ? 0.488   -17.841 -57.719 1.00 197.97 ? 1019 LYS A O   1 
ATOM   1548 C CB  . LYS A 1 255 ? 2.159   -15.600 -57.813 1.00 190.75 ? 1019 LYS A CB  1 
ATOM   1549 C CG  . LYS A 1 255 ? 3.103   -14.499 -58.249 1.00 174.59 ? 1019 LYS A CG  1 
ATOM   1550 C CD  . LYS A 1 255 ? 4.401   -14.573 -57.476 1.00 222.77 ? 1019 LYS A CD  1 
ATOM   1551 C CE  . LYS A 1 255 ? 5.535   -13.927 -58.236 1.00 203.07 ? 1019 LYS A CE  1 
ATOM   1552 N NZ  . LYS A 1 255 ? 5.453   -12.447 -58.333 1.00 188.98 ? 1019 LYS A NZ  1 
ATOM   1553 N N   . ALA A 1 256 ? -0.798  -17.153 -59.430 1.00 187.14 ? 1020 ALA A N   1 
ATOM   1554 C CA  . ALA A 1 256 ? -1.421  -18.457 -59.620 1.00 190.34 ? 1020 ALA A CA  1 
ATOM   1555 C C   . ALA A 1 256 ? -2.227  -18.470 -60.911 1.00 206.28 ? 1020 ALA A C   1 
ATOM   1556 O O   . ALA A 1 256 ? -3.049  -17.578 -61.145 1.00 197.77 ? 1020 ALA A O   1 
ATOM   1557 C CB  . ALA A 1 256 ? -2.314  -18.813 -58.431 1.00 174.54 ? 1020 ALA A CB  1 
ATOM   1558 N N   . ASP A 1 257 ? -1.996  -19.474 -61.754 1.00 210.15 ? 1021 ASP A N   1 
ATOM   1559 C CA  . ASP A 1 257 ? -2.701  -19.614 -63.020 1.00 204.37 ? 1021 ASP A CA  1 
ATOM   1560 C C   . ASP A 1 257 ? -3.907  -20.540 -62.920 1.00 213.69 ? 1021 ASP A C   1 
ATOM   1561 O O   . ASP A 1 257 ? -4.556  -20.800 -63.938 1.00 236.65 ? 1021 ASP A O   1 
ATOM   1562 C CB  . ASP A 1 257 ? -1.738  -20.127 -64.099 1.00 218.80 ? 1021 ASP A CB  1 
ATOM   1563 C CG  . ASP A 1 257 ? -2.253  -19.894 -65.511 1.00 216.54 ? 1021 ASP A CG  1 
ATOM   1564 O OD1 . ASP A 1 257 ? -3.337  -19.293 -65.665 1.00 233.60 ? 1021 ASP A OD1 1 
ATOM   1565 O OD2 . ASP A 1 257 ? -1.568  -20.311 -66.469 1.00 210.26 ? 1021 ASP A OD2 1 
ATOM   1566 N N   . ASN A 1 258 ? -4.224  -21.038 -61.727 1.00 203.55 ? 1022 ASN A N   1 
ATOM   1567 C CA  . ASN A 1 258 ? -5.330  -21.961 -61.519 1.00 210.95 ? 1022 ASN A CA  1 
ATOM   1568 C C   . ASN A 1 258 ? -6.474  -21.262 -60.797 1.00 179.00 ? 1022 ASN A C   1 
ATOM   1569 O O   . ASN A 1 258 ? -6.251  -20.466 -59.880 1.00 177.76 ? 1022 ASN A O   1 
ATOM   1570 C CB  . ASN A 1 258 ? -4.885  -23.183 -60.710 1.00 209.11 ? 1022 ASN A CB  1 
ATOM   1571 C CG  . ASN A 1 258 ? -4.225  -24.242 -61.570 1.00 217.07 ? 1022 ASN A CG  1 
ATOM   1572 O OD1 . ASN A 1 258 ? -4.900  -24.999 -62.268 1.00 215.08 ? 1022 ASN A OD1 1 
ATOM   1573 N ND2 . ASN A 1 258 ? -2.900  -24.304 -61.520 1.00 231.60 ? 1022 ASN A ND2 1 
ATOM   1574 N N   . ALA A 1 259 ? -7.703  -21.568 -61.220 1.00 185.67 ? 1023 ALA A N   1 
ATOM   1575 C CA  . ALA A 1 259 ? -8.892  -21.000 -60.597 1.00 196.80 ? 1023 ALA A CA  1 
ATOM   1576 C C   . ALA A 1 259 ? -9.128  -21.519 -59.184 1.00 184.82 ? 1023 ALA A C   1 
ATOM   1577 O O   . ALA A 1 259 ? -9.942  -20.935 -58.459 1.00 184.21 ? 1023 ALA A O   1 
ATOM   1578 C CB  . ALA A 1 259 ? -10.121 -21.293 -61.460 1.00 214.57 ? 1023 ALA A CB  1 
ATOM   1579 N N   . ALA A 1 260 ? -8.454  -22.597 -58.779 1.00 172.84 ? 1024 ALA A N   1 
ATOM   1580 C CA  . ALA A 1 260 ? -8.636  -23.133 -57.435 1.00 180.91 ? 1024 ALA A CA  1 
ATOM   1581 C C   . ALA A 1 260 ? -7.781  -22.403 -56.408 1.00 186.65 ? 1024 ALA A C   1 
ATOM   1582 O O   . ALA A 1 260 ? -8.194  -22.260 -55.250 1.00 189.48 ? 1024 ALA A O   1 
ATOM   1583 C CB  . ALA A 1 260 ? -8.308  -24.626 -57.416 1.00 183.29 ? 1024 ALA A CB  1 
ATOM   1584 N N   . GLN A 1 261 ? -6.590  -21.953 -56.805 1.00 156.90 ? 1025 GLN A N   1 
ATOM   1585 C CA  . GLN A 1 261 ? -5.761  -21.173 -55.895 1.00 158.71 ? 1025 GLN A CA  1 
ATOM   1586 C C   . GLN A 1 261 ? -6.491  -19.913 -55.447 1.00 175.58 ? 1025 GLN A C   1 
ATOM   1587 O O   . GLN A 1 261 ? -6.428  -19.530 -54.271 1.00 185.91 ? 1025 GLN A O   1 
ATOM   1588 C CB  . GLN A 1 261 ? -4.437  -20.821 -56.571 1.00 147.43 ? 1025 GLN A CB  1 
ATOM   1589 N N   . VAL A 1 262 ? -7.194  -19.258 -56.374 1.00 154.49 ? 1026 VAL A N   1 
ATOM   1590 C CA  . VAL A 1 262 ? -7.949  -18.057 -56.030 1.00 179.25 ? 1026 VAL A CA  1 
ATOM   1591 C C   . VAL A 1 262 ? -9.039  -18.385 -55.021 1.00 176.04 ? 1026 VAL A C   1 
ATOM   1592 O O   . VAL A 1 262 ? -9.241  -17.654 -54.045 1.00 195.88 ? 1026 VAL A O   1 
ATOM   1593 C CB  . VAL A 1 262 ? -8.535  -17.411 -57.299 1.00 193.45 ? 1026 VAL A CB  1 
ATOM   1594 C CG1 . VAL A 1 262 ? -9.493  -16.287 -56.931 1.00 173.83 ? 1026 VAL A CG1 1 
ATOM   1595 C CG2 . VAL A 1 262 ? -7.419  -16.895 -58.194 1.00 190.85 ? 1026 VAL A CG2 1 
ATOM   1596 N N   . LYS A 1 263 ? -9.762  -19.484 -55.240 1.00 156.71 ? 1027 LYS A N   1 
ATOM   1597 C CA  . LYS A 1 263 ? -10.813 -19.868 -54.304 1.00 169.66 ? 1027 LYS A CA  1 
ATOM   1598 C C   . LYS A 1 263 ? -10.240 -20.138 -52.917 1.00 186.14 ? 1027 LYS A C   1 
ATOM   1599 O O   . LYS A 1 263 ? -10.803 -19.697 -51.908 1.00 191.14 ? 1027 LYS A O   1 
ATOM   1600 C CB  . LYS A 1 263 ? -11.554 -21.097 -54.829 1.00 164.35 ? 1027 LYS A CB  1 
ATOM   1601 N N   . ASP A 1 264 ? -9.114  -20.852 -52.847 1.00 184.37 ? 1028 ASP A N   1 
ATOM   1602 C CA  . ASP A 1 264 ? -8.505  -21.149 -51.552 1.00 165.44 ? 1028 ASP A CA  1 
ATOM   1603 C C   . ASP A 1 264 ? -8.081  -19.872 -50.837 1.00 171.08 ? 1028 ASP A C   1 
ATOM   1604 O O   . ASP A 1 264 ? -8.384  -19.675 -49.651 1.00 178.91 ? 1028 ASP A O   1 
ATOM   1605 C CB  . ASP A 1 264 ? -7.303  -22.073 -51.737 1.00 170.90 ? 1028 ASP A CB  1 
ATOM   1606 C CG  . ASP A 1 264 ? -7.706  -23.515 -51.941 1.00 183.45 ? 1028 ASP A CG  1 
ATOM   1607 O OD1 . ASP A 1 264 ? -8.287  -23.828 -53.001 1.00 196.43 ? 1028 ASP A OD1 1 
ATOM   1608 O OD2 . ASP A 1 264 ? -7.440  -24.335 -51.037 1.00 206.12 ? 1028 ASP A OD2 1 
ATOM   1609 N N   . ALA A 1 265 ? -7.367  -18.994 -51.542 1.00 149.40 ? 1029 ALA A N   1 
ATOM   1610 C CA  . ALA A 1 265 ? -6.899  -17.764 -50.917 1.00 151.52 ? 1029 ALA A CA  1 
ATOM   1611 C C   . ALA A 1 265 ? -8.068  -16.900 -50.470 1.00 174.66 ? 1029 ALA A C   1 
ATOM   1612 O O   . ALA A 1 265 ? -8.022  -16.291 -49.397 1.00 189.24 ? 1029 ALA A O   1 
ATOM   1613 C CB  . ALA A 1 265 ? -6.000  -16.994 -51.881 1.00 167.43 ? 1029 ALA A CB  1 
ATOM   1614 N N   . LEU A 1 266 ? -9.132  -16.838 -51.276 1.00 170.07 ? 1030 LEU A N   1 
ATOM   1615 C CA  . LEU A 1 266 ? -10.284 -16.019 -50.916 1.00 179.29 ? 1030 LEU A CA  1 
ATOM   1616 C C   . LEU A 1 266 ? -11.023 -16.592 -49.714 1.00 201.98 ? 1030 LEU A C   1 
ATOM   1617 O O   . LEU A 1 266 ? -11.504 -15.838 -48.863 1.00 192.72 ? 1030 LEU A O   1 
ATOM   1618 C CB  . LEU A 1 266 ? -11.225 -15.887 -52.111 1.00 201.71 ? 1030 LEU A CB  1 
ATOM   1619 C CG  . LEU A 1 266 ? -10.821 -14.833 -53.144 1.00 200.95 ? 1030 LEU A CG  1 
ATOM   1620 C CD1 . LEU A 1 266 ? -11.621 -15.007 -54.426 1.00 188.44 ? 1030 LEU A CD1 1 
ATOM   1621 C CD2 . LEU A 1 266 ? -11.012 -13.432 -52.576 1.00 194.29 ? 1030 LEU A CD2 1 
ATOM   1622 N N   . THR A 1 267 ? -11.139 -17.919 -49.627 1.00 202.49 ? 1031 THR A N   1 
ATOM   1623 C CA  . THR A 1 267 ? -11.775 -18.517 -48.457 1.00 199.77 ? 1031 THR A CA  1 
ATOM   1624 C C   . THR A 1 267 ? -10.961 -18.256 -47.195 1.00 181.94 ? 1031 THR A C   1 
ATOM   1625 O O   . THR A 1 267 ? -11.522 -17.936 -46.139 1.00 178.29 ? 1031 THR A O   1 
ATOM   1626 C CB  . THR A 1 267 ? -11.967 -20.019 -48.669 1.00 194.73 ? 1031 THR A CB  1 
ATOM   1627 O OG1 . THR A 1 267 ? -10.735 -20.606 -49.108 1.00 200.25 ? 1031 THR A OG1 1 
ATOM   1628 C CG2 . THR A 1 267 ? -13.055 -20.276 -49.703 1.00 185.88 ? 1031 THR A CG2 1 
ATOM   1629 N N   . LYS A 1 268 ? -9.636  -18.389 -47.283 1.00 172.14 ? 1032 LYS A N   1 
ATOM   1630 C CA  . LYS A 1 268 ? -8.794  -18.084 -46.128 1.00 175.04 ? 1032 LYS A CA  1 
ATOM   1631 C C   . LYS A 1 268 ? -8.914  -16.611 -45.743 1.00 172.20 ? 1032 LYS A C   1 
ATOM   1632 O O   . LYS A 1 268 ? -8.967  -16.268 -44.554 1.00 191.73 ? 1032 LYS A O   1 
ATOM   1633 C CB  . LYS A 1 268 ? -7.343  -18.460 -46.434 1.00 171.55 ? 1032 LYS A CB  1 
ATOM   1634 C CG  . LYS A 1 268 ? -7.147  -19.943 -46.752 1.00 156.80 ? 1032 LYS A CG  1 
ATOM   1635 C CD  . LYS A 1 268 ? -5.754  -20.235 -47.297 1.00 152.89 ? 1032 LYS A CD  1 
ATOM   1636 C CE  . LYS A 1 268 ? -5.596  -21.708 -47.654 1.00 145.60 ? 1032 LYS A CE  1 
ATOM   1637 N NZ  . LYS A 1 268 ? -4.230  -22.033 -48.159 1.00 148.94 ? 1032 LYS A NZ  1 
ATOM   1638 N N   . MET A 1 269 ? -8.969  -15.729 -46.743 1.00 181.16 ? 1033 MET A N   1 
ATOM   1639 C CA  . MET A 1 269 ? -9.160  -14.305 -46.492 1.00 190.14 ? 1033 MET A CA  1 
ATOM   1640 C C   . MET A 1 269 ? -10.488 -14.046 -45.793 1.00 191.45 ? 1033 MET A C   1 
ATOM   1641 O O   . MET A 1 269 ? -10.566 -13.243 -44.853 1.00 199.98 ? 1033 MET A O   1 
ATOM   1642 C CB  . MET A 1 269 ? -9.094  -13.561 -47.828 1.00 198.47 ? 1033 MET A CB  1 
ATOM   1643 C CG  . MET A 1 269 ? -8.778  -12.083 -47.745 1.00 202.19 ? 1033 MET A CG  1 
ATOM   1644 S SD  . MET A 1 269 ? -8.707  -11.321 -49.385 1.00 186.81 ? 1033 MET A SD  1 
ATOM   1645 C CE  . MET A 1 269 ? -7.408  -12.281 -50.164 1.00 153.38 ? 1033 MET A CE  1 
ATOM   1646 N N   . ARG A 1 270 ? -11.546 -14.723 -46.243 1.00 183.57 ? 1034 ARG A N   1 
ATOM   1647 C CA  . ARG A 1 270 ? -12.853 -14.595 -45.612 1.00 181.69 ? 1034 ARG A CA  1 
ATOM   1648 C C   . ARG A 1 270 ? -12.805 -15.040 -44.157 1.00 195.51 ? 1034 ARG A C   1 
ATOM   1649 O O   . ARG A 1 270 ? -13.357 -14.372 -43.274 1.00 204.62 ? 1034 ARG A O   1 
ATOM   1650 C CB  . ARG A 1 270 ? -13.874 -15.422 -46.396 1.00 180.21 ? 1034 ARG A CB  1 
ATOM   1651 C CG  . ARG A 1 270 ? -15.309 -15.271 -45.930 1.00 184.28 ? 1034 ARG A CG  1 
ATOM   1652 C CD  . ARG A 1 270 ? -16.275 -15.897 -46.926 1.00 190.27 ? 1034 ARG A CD  1 
ATOM   1653 N NE  . ARG A 1 270 ? -17.654 -15.497 -46.670 1.00 186.75 ? 1034 ARG A NE  1 
ATOM   1654 C CZ  . ARG A 1 270 ? -18.689 -15.842 -47.424 1.00 190.79 ? 1034 ARG A CZ  1 
ATOM   1655 N NH1 . ARG A 1 270 ? -18.542 -16.609 -48.492 1.00 190.00 ? 1034 ARG A NH1 1 
ATOM   1656 N NH2 . ARG A 1 270 ? -19.901 -15.402 -47.099 1.00 198.81 ? 1034 ARG A NH2 1 
ATOM   1657 N N   . ALA A 1 271 ? -12.150 -16.172 -43.891 1.00 186.08 ? 1035 ALA A N   1 
ATOM   1658 C CA  . ALA A 1 271 ? -12.046 -16.659 -42.519 1.00 162.31 ? 1035 ALA A CA  1 
ATOM   1659 C C   . ALA A 1 271 ? -11.303 -15.664 -41.638 1.00 168.69 ? 1035 ALA A C   1 
ATOM   1660 O O   . ALA A 1 271 ? -11.711 -15.400 -40.499 1.00 193.77 ? 1035 ALA A O   1 
ATOM   1661 C CB  . ALA A 1 271 ? -11.348 -18.018 -42.498 1.00 168.31 ? 1035 ALA A CB  1 
ATOM   1662 N N   . ALA A 1 272 ? -10.206 -15.101 -42.150 1.00 156.00 ? 1036 ALA A N   1 
ATOM   1663 C CA  . ALA A 1 272 ? -9.465  -14.103 -41.385 1.00 173.00 ? 1036 ALA A CA  1 
ATOM   1664 C C   . ALA A 1 272 ? -10.337 -12.888 -41.082 1.00 195.86 ? 1036 ALA A C   1 
ATOM   1665 O O   . ALA A 1 272 ? -10.355 -12.385 -39.946 1.00 222.77 ? 1036 ALA A O   1 
ATOM   1666 C CB  . ALA A 1 272 ? -8.210  -13.688 -42.155 1.00 179.49 ? 1036 ALA A CB  1 
ATOM   1667 N N   . ALA A 1 273 ? -11.074 -12.408 -42.086 1.00 188.39 ? 1037 ALA A N   1 
ATOM   1668 C CA  . ALA A 1 273 ? -11.936 -11.249 -41.881 1.00 196.56 ? 1037 ALA A CA  1 
ATOM   1669 C C   . ALA A 1 273 ? -12.991 -11.533 -40.818 1.00 205.61 ? 1037 ALA A C   1 
ATOM   1670 O O   . ALA A 1 273 ? -13.264 -10.688 -39.953 1.00 217.19 ? 1037 ALA A O   1 
ATOM   1671 C CB  . ALA A 1 273 ? -12.598 -10.850 -43.201 1.00 184.36 ? 1037 ALA A CB  1 
ATOM   1672 N N   . LEU A 1 274 ? -13.591 -12.723 -40.862 1.00 215.93 ? 1038 LEU A N   1 
ATOM   1673 C CA  . LEU A 1 274 ? -14.638 -13.052 -39.901 1.00 206.38 ? 1038 LEU A CA  1 
ATOM   1674 C C   . LEU A 1 274 ? -14.073 -13.196 -38.490 1.00 204.83 ? 1038 LEU A C   1 
ATOM   1675 O O   . LEU A 1 274 ? -14.726 -12.807 -37.514 1.00 216.30 ? 1038 LEU A O   1 
ATOM   1676 C CB  . LEU A 1 274 ? -15.364 -14.321 -40.344 1.00 209.17 ? 1038 LEU A CB  1 
ATOM   1677 C CG  . LEU A 1 274 ? -16.065 -14.189 -41.702 1.00 192.98 ? 1038 LEU A CG  1 
ATOM   1678 C CD1 . LEU A 1 274 ? -16.550 -15.542 -42.198 1.00 201.75 ? 1038 LEU A CD1 1 
ATOM   1679 C CD2 . LEU A 1 274 ? -17.223 -13.199 -41.635 1.00 186.14 ? 1038 LEU A CD2 1 
ATOM   1680 N N   . ASP A 1 275 ? -12.859 -13.737 -38.356 1.00 191.62 ? 1039 ASP A N   1 
ATOM   1681 C CA  . ASP A 1 275 ? -12.212 -13.761 -37.045 1.00 198.34 ? 1039 ASP A CA  1 
ATOM   1682 C C   . ASP A 1 275 ? -12.035 -12.344 -36.501 1.00 204.51 ? 1039 ASP A C   1 
ATOM   1683 O O   . ASP A 1 275 ? -12.411 -12.040 -35.353 1.00 202.86 ? 1039 ASP A O   1 
ATOM   1684 C CB  . ASP A 1 275 ? -10.860 -14.472 -37.145 1.00 178.90 ? 1039 ASP A CB  1 
ATOM   1685 C CG  . ASP A 1 275 ? -10.998 -15.952 -37.457 1.00 168.87 ? 1039 ASP A CG  1 
ATOM   1686 O OD1 . ASP A 1 275 ? -12.143 -16.430 -37.599 1.00 165.19 ? 1039 ASP A OD1 1 
ATOM   1687 O OD2 . ASP A 1 275 ? -9.959  -16.638 -37.561 1.00 150.49 ? 1039 ASP A OD2 1 
ATOM   1688 N N   . ALA A 1 276 ? -11.480 -11.452 -37.328 1.00 201.86 ? 1040 ALA A N   1 
ATOM   1689 C CA  . ALA A 1 276 ? -11.268 -10.077 -36.886 1.00 196.79 ? 1040 ALA A CA  1 
ATOM   1690 C C   . ALA A 1 276 ? -12.580 -9.430  -36.466 1.00 190.91 ? 1040 ALA A C   1 
ATOM   1691 O O   . ALA A 1 276 ? -12.627 -8.678  -35.485 1.00 196.68 ? 1040 ALA A O   1 
ATOM   1692 C CB  . ALA A 1 276 ? -10.602 -9.263  -37.993 1.00 193.74 ? 1040 ALA A CB  1 
ATOM   1693 N N   . GLN A 1 277 ? -13.659 -9.707  -37.201 1.00 210.92 ? 1041 GLN A N   1 
ATOM   1694 C CA  . GLN A 1 277 ? -14.966 -9.195  -36.801 1.00 199.32 ? 1041 GLN A CA  1 
ATOM   1695 C C   . GLN A 1 277 ? -15.385 -9.761  -35.449 1.00 202.29 ? 1041 GLN A C   1 
ATOM   1696 O O   . GLN A 1 277 ? -15.906 -9.034  -34.595 1.00 195.61 ? 1041 GLN A O   1 
ATOM   1697 C CB  . GLN A 1 277 ? -16.008 -9.530  -37.868 1.00 201.35 ? 1041 GLN A CB  1 
ATOM   1698 N N   . LYS A 1 278 ? -15.152 -11.059 -35.234 1.00 194.95 ? 1042 LYS A N   1 
ATOM   1699 C CA  . LYS A 1 278 ? -15.548 -11.687 -33.979 1.00 183.44 ? 1042 LYS A CA  1 
ATOM   1700 C C   . LYS A 1 278 ? -14.849 -11.052 -32.787 1.00 221.30 ? 1042 LYS A C   1 
ATOM   1701 O O   . LYS A 1 278 ? -15.394 -11.055 -31.677 1.00 206.69 ? 1042 LYS A O   1 
ATOM   1702 C CB  . LYS A 1 278 ? -15.243 -13.184 -34.024 1.00 163.40 ? 1042 LYS A CB  1 
ATOM   1703 N N   . ALA A 1 279 ? -13.648 -10.504 -32.993 1.00 210.05 ? 1043 ALA A N   1 
ATOM   1704 C CA  . ALA A 1 279 ? -12.880 -9.978  -31.863 1.00 198.18 ? 1043 ALA A CA  1 
ATOM   1705 C C   . ALA A 1 279 ? -13.649 -8.901  -31.099 1.00 197.30 ? 1043 ALA A C   1 
ATOM   1706 O O   . ALA A 1 279 ? -13.830 -8.999  -29.877 1.00 195.15 ? 1043 ALA A O   1 
ATOM   1707 C CB  . ALA A 1 279 ? -11.543 -9.422  -32.353 1.00 183.29 ? 1043 ALA A CB  1 
ATOM   1708 N N   . THR A 1 280 ? -14.113 -7.861  -31.796 1.00 199.47 ? 1044 THR A N   1 
ATOM   1709 C CA  . THR A 1 280 ? -14.731 -6.707  -31.135 1.00 209.38 ? 1044 THR A CA  1 
ATOM   1710 C C   . THR A 1 280 ? -15.788 -6.039  -32.003 1.00 227.66 ? 1044 THR A C   1 
ATOM   1711 O O   . THR A 1 280 ? -15.437 -5.295  -32.926 1.00 229.44 ? 1044 THR A O   1 
ATOM   1712 C CB  . THR A 1 280 ? -13.677 -5.661  -30.776 1.00 198.93 ? 1044 THR A CB  1 
ATOM   1713 O OG1 . THR A 1 280 ? -12.723 -5.555  -31.845 1.00 186.23 ? 1044 THR A OG1 1 
ATOM   1714 C CG2 . THR A 1 280 ? -12.965 -5.990  -29.476 1.00 206.16 ? 1044 THR A CG2 1 
ATOM   1715 N N   . PRO A 1 281 ? -17.078 -6.249  -31.742 1.00 220.05 ? 1045 PRO A N   1 
ATOM   1716 C CA  . PRO A 1 281 ? -18.088 -5.371  -32.358 1.00 232.12 ? 1045 PRO A CA  1 
ATOM   1717 C C   . PRO A 1 281 ? -17.855 -3.927  -31.946 1.00 235.46 ? 1045 PRO A C   1 
ATOM   1718 O O   . PRO A 1 281 ? -17.942 -3.016  -32.783 1.00 239.24 ? 1045 PRO A O   1 
ATOM   1719 C CB  . PRO A 1 281 ? -19.431 -5.911  -31.835 1.00 228.53 ? 1045 PRO A CB  1 
ATOM   1720 C CG  . PRO A 1 281 ? -19.118 -7.072  -30.929 1.00 224.85 ? 1045 PRO A CG  1 
ATOM   1721 C CD  . PRO A 1 281 ? -17.669 -7.426  -31.084 1.00 215.40 ? 1045 PRO A CD  1 
ATOM   1722 N N   . PRO A 1 282 ? -17.540 -3.668  -30.662 1.00 233.44 ? 1046 PRO A N   1 
ATOM   1723 C CA  . PRO A 1 282 ? -16.994 -2.389  -30.232 1.00 226.29 ? 1046 PRO A CA  1 
ATOM   1724 C C   . PRO A 1 282 ? -15.532 -2.567  -29.888 1.00 208.01 ? 1046 PRO A C   1 
ATOM   1725 O O   . PRO A 1 282 ? -15.208 -3.347  -28.989 1.00 190.20 ? 1046 PRO A O   1 
ATOM   1726 C CB  . PRO A 1 282 ? -17.814 -2.068  -28.989 1.00 233.33 ? 1046 PRO A CB  1 
ATOM   1727 C CG  . PRO A 1 282 ? -18.122 -3.441  -28.400 1.00 243.16 ? 1046 PRO A CG  1 
ATOM   1728 C CD  . PRO A 1 282 ? -17.817 -4.484  -29.473 1.00 236.14 ? 1046 PRO A CD  1 
ATOM   1729 N N   . HIS A 1 299 ? -18.595 2.362   -39.936 1.00 238.61 ? 1063 HIS A N   1 
ATOM   1730 C CA  . HIS A 1 299 ? -17.744 1.599   -39.031 1.00 226.30 ? 1063 HIS A CA  1 
ATOM   1731 C C   . HIS A 1 299 ? -17.922 0.100   -39.246 1.00 234.70 ? 1063 HIS A C   1 
ATOM   1732 O O   . HIS A 1 299 ? -17.708 -0.693  -38.330 1.00 222.51 ? 1063 HIS A O   1 
ATOM   1733 C CB  . HIS A 1 299 ? -18.053 1.957   -37.576 1.00 183.85 ? 1063 HIS A CB  1 
ATOM   1734 N N   . GLY A 1 300 ? -18.308 -0.281  -40.462 1.00 239.75 ? 1064 GLY A N   1 
ATOM   1735 C CA  . GLY A 1 300 ? -18.560 -1.675  -40.771 1.00 227.31 ? 1064 GLY A CA  1 
ATOM   1736 C C   . GLY A 1 300 ? -17.658 -2.236  -41.850 1.00 210.05 ? 1064 GLY A C   1 
ATOM   1737 O O   . GLY A 1 300 ? -17.593 -1.698  -42.960 1.00 205.66 ? 1064 GLY A O   1 
ATOM   1738 N N   . PHE A 1 301 ? -16.948 -3.316  -41.529 1.00 211.76 ? 1065 PHE A N   1 
ATOM   1739 C CA  . PHE A 1 301 ? -16.178 -4.067  -42.508 1.00 194.07 ? 1065 PHE A CA  1 
ATOM   1740 C C   . PHE A 1 301 ? -16.949 -5.262  -43.045 1.00 190.60 ? 1065 PHE A C   1 
ATOM   1741 O O   . PHE A 1 301 ? -16.399 -6.040  -43.830 1.00 184.29 ? 1065 PHE A O   1 
ATOM   1742 C CB  . PHE A 1 301 ? -14.851 -4.534  -41.902 1.00 201.32 ? 1065 PHE A CB  1 
ATOM   1743 N N   . ASP A 1 302 ? -18.213 -5.424  -42.643 1.00 199.67 ? 1066 ASP A N   1 
ATOM   1744 C CA  . ASP A 1 302 ? -19.067 -6.388  -43.318 1.00 190.15 ? 1066 ASP A CA  1 
ATOM   1745 C C   . ASP A 1 302 ? -19.148 -6.071  -44.799 1.00 181.03 ? 1066 ASP A C   1 
ATOM   1746 O O   . ASP A 1 302 ? -19.442 -6.959  -45.602 1.00 178.68 ? 1066 ASP A O   1 
ATOM   1747 C CB  . ASP A 1 302 ? -20.466 -6.397  -42.698 1.00 199.27 ? 1066 ASP A CB  1 
ATOM   1748 C CG  . ASP A 1 302 ? -21.153 -5.048  -42.789 1.00 206.55 ? 1066 ASP A CG  1 
ATOM   1749 O OD1 . ASP A 1 302 ? -20.506 -4.078  -43.238 1.00 203.74 ? 1066 ASP A OD1 1 
ATOM   1750 O OD2 . ASP A 1 302 ? -22.341 -4.958  -42.414 1.00 203.97 ? 1066 ASP A OD2 1 
ATOM   1751 N N   . ILE A 1 303 ? -18.892 -4.813  -45.169 1.00 193.12 ? 1067 ILE A N   1 
ATOM   1752 C CA  . ILE A 1 303 ? -18.716 -4.461  -46.572 1.00 178.14 ? 1067 ILE A CA  1 
ATOM   1753 C C   . ILE A 1 303 ? -17.537 -5.216  -47.163 1.00 182.04 ? 1067 ILE A C   1 
ATOM   1754 O O   . ILE A 1 303 ? -17.611 -5.713  -48.289 1.00 194.06 ? 1067 ILE A O   1 
ATOM   1755 C CB  . ILE A 1 303 ? -18.525 -2.942  -46.732 1.00 185.73 ? 1067 ILE A CB  1 
ATOM   1756 C CG1 . ILE A 1 303 ? -18.418 -2.581  -48.216 1.00 180.66 ? 1067 ILE A CG1 1 
ATOM   1757 C CG2 . ILE A 1 303 ? -17.276 -2.485  -45.985 1.00 196.76 ? 1067 ILE A CG2 1 
ATOM   1758 C CD1 . ILE A 1 303 ? -18.115 -1.125  -48.474 1.00 173.83 ? 1067 ILE A CD1 1 
ATOM   1759 N N   . LEU A 1 304 ? -16.416 -5.275  -46.441 1.00 174.91 ? 1068 LEU A N   1 
ATOM   1760 C CA  . LEU A 1 304 ? -15.283 -6.047  -46.938 1.00 184.01 ? 1068 LEU A CA  1 
ATOM   1761 C C   . LEU A 1 304 ? -15.660 -7.513  -47.066 1.00 166.79 ? 1068 LEU A C   1 
ATOM   1762 O O   . LEU A 1 304 ? -15.258 -8.186  -48.021 1.00 179.17 ? 1068 LEU A O   1 
ATOM   1763 C CB  . LEU A 1 304 ? -14.069 -5.894  -46.020 1.00 183.52 ? 1068 LEU A CB  1 
ATOM   1764 C CG  . LEU A 1 304 ? -12.875 -6.795  -46.372 1.00 180.44 ? 1068 LEU A CG  1 
ATOM   1765 C CD1 . LEU A 1 304 ? -11.576 -6.209  -45.848 1.00 174.07 ? 1068 LEU A CD1 1 
ATOM   1766 C CD2 . LEU A 1 304 ? -13.051 -8.219  -45.839 1.00 174.37 ? 1068 LEU A CD2 1 
ATOM   1767 N N   . VAL A 1 305 ? -16.411 -8.031  -46.094 1.00 193.76 ? 1069 VAL A N   1 
ATOM   1768 C CA  . VAL A 1 305 ? -16.894 -9.402  -46.193 1.00 183.26 ? 1069 VAL A CA  1 
ATOM   1769 C C   . VAL A 1 305 ? -17.707 -9.567  -47.468 1.00 180.99 ? 1069 VAL A C   1 
ATOM   1770 O O   . VAL A 1 305 ? -17.570 -10.561 -48.187 1.00 183.08 ? 1069 VAL A O   1 
ATOM   1771 C CB  . VAL A 1 305 ? -17.721 -9.777  -44.949 1.00 203.44 ? 1069 VAL A CB  1 
ATOM   1772 C CG1 . VAL A 1 305 ? -18.076 -11.256 -44.977 1.00 182.58 ? 1069 VAL A CG1 1 
ATOM   1773 C CG2 . VAL A 1 305 ? -16.976 -9.432  -43.665 1.00 173.04 ? 1069 VAL A CG2 1 
ATOM   1774 N N   . GLY A 1 306 ? -18.554 -8.584  -47.773 1.00 201.05 ? 1070 GLY A N   1 
ATOM   1775 C CA  . GLY A 1 306 ? -19.370 -8.658  -48.973 1.00 187.02 ? 1070 GLY A CA  1 
ATOM   1776 C C   . GLY A 1 306 ? -18.556 -8.570  -50.250 1.00 175.78 ? 1070 GLY A C   1 
ATOM   1777 O O   . GLY A 1 306 ? -18.862 -9.239  -51.238 1.00 171.43 ? 1070 GLY A O   1 
ATOM   1778 N N   . GLN A 1 307 ? -17.525 -7.727  -50.257 1.00 171.35 ? 1071 GLN A N   1 
ATOM   1779 C CA  . GLN A 1 307 ? -16.657 -7.633  -51.426 1.00 163.77 ? 1071 GLN A CA  1 
ATOM   1780 C C   . GLN A 1 307 ? -15.896 -8.938  -51.637 1.00 188.14 ? 1071 GLN A C   1 
ATOM   1781 O O   . GLN A 1 307 ? -15.719 -9.388  -52.776 1.00 204.93 ? 1071 GLN A O   1 
ATOM   1782 C CB  . GLN A 1 307 ? -15.684 -6.461  -51.279 1.00 145.58 ? 1071 GLN A CB  1 
ATOM   1783 C CG  . GLN A 1 307 ? -16.320 -5.095  -50.998 1.00 167.82 ? 1071 GLN A CG  1 
ATOM   1784 C CD  . GLN A 1 307 ? -17.742 -4.966  -51.518 1.00 188.90 ? 1071 GLN A CD  1 
ATOM   1785 O OE1 . GLN A 1 307 ? -17.981 -4.980  -52.726 1.00 202.04 ? 1071 GLN A OE1 1 
ATOM   1786 N NE2 . GLN A 1 307 ? -18.694 -4.835  -50.601 1.00 178.52 ? 1071 GLN A NE2 1 
ATOM   1787 N N   . ILE A 1 308 ? -15.443 -9.562  -50.548 1.00 177.99 ? 1072 ILE A N   1 
ATOM   1788 C CA  . ILE A 1 308 ? -14.817 -10.876 -50.644 1.00 154.10 ? 1072 ILE A CA  1 
ATOM   1789 C C   . ILE A 1 308 ? -15.823 -11.911 -51.123 1.00 164.33 ? 1072 ILE A C   1 
ATOM   1790 O O   . ILE A 1 308 ? -15.465 -12.853 -51.835 1.00 185.43 ? 1072 ILE A O   1 
ATOM   1791 C CB  . ILE A 1 308 ? -14.190 -11.268 -49.290 1.00 187.17 ? 1072 ILE A CB  1 
ATOM   1792 C CG1 . ILE A 1 308 ? -12.939 -10.418 -49.039 1.00 196.88 ? 1072 ILE A CG1 1 
ATOM   1793 C CG2 . ILE A 1 308 ? -13.875 -12.764 -49.253 1.00 171.28 ? 1072 ILE A CG2 1 
ATOM   1794 C CD1 . ILE A 1 308 ? -12.114 -10.841 -47.843 1.00 173.51 ? 1072 ILE A CD1 1 
ATOM   1795 N N   . ASP A 1 309 ? -17.091 -11.765 -50.736 1.00 193.12 ? 1073 ASP A N   1 
ATOM   1796 C CA  . ASP A 1 309 ? -18.130 -12.651 -51.253 1.00 198.01 ? 1073 ASP A CA  1 
ATOM   1797 C C   . ASP A 1 309 ? -18.311 -12.468 -52.756 1.00 180.72 ? 1073 ASP A C   1 
ATOM   1798 O O   . ASP A 1 309 ? -18.482 -13.445 -53.493 1.00 199.45 ? 1073 ASP A O   1 
ATOM   1799 C CB  . ASP A 1 309 ? -19.447 -12.399 -50.516 1.00 205.62 ? 1073 ASP A CB  1 
ATOM   1800 C CG  . ASP A 1 309 ? -19.390 -12.812 -49.054 1.00 189.49 ? 1073 ASP A CG  1 
ATOM   1801 O OD1 . ASP A 1 309 ? -18.311 -13.245 -48.598 1.00 189.66 ? 1073 ASP A OD1 1 
ATOM   1802 O OD2 . ASP A 1 309 ? -20.426 -12.706 -48.363 1.00 182.72 ? 1073 ASP A OD2 1 
ATOM   1803 N N   . ASP A 1 310 ? -18.288 -11.218 -53.226 1.00 194.21 ? 1074 ASP A N   1 
ATOM   1804 C CA  . ASP A 1 310 ? -18.352 -10.959 -54.663 1.00 189.43 ? 1074 ASP A CA  1 
ATOM   1805 C C   . ASP A 1 310 ? -17.176 -11.608 -55.381 1.00 182.95 ? 1074 ASP A C   1 
ATOM   1806 O O   . ASP A 1 310 ? -17.338 -12.233 -56.440 1.00 187.07 ? 1074 ASP A O   1 
ATOM   1807 C CB  . ASP A 1 310 ? -18.352 -9.451  -54.930 1.00 180.44 ? 1074 ASP A CB  1 
ATOM   1808 C CG  . ASP A 1 310 ? -19.468 -8.724  -54.207 1.00 181.97 ? 1074 ASP A CG  1 
ATOM   1809 O OD1 . ASP A 1 310 ? -20.240 -9.383  -53.480 1.00 190.43 ? 1074 ASP A OD1 1 
ATOM   1810 O OD2 . ASP A 1 310 ? -19.571 -7.488  -54.367 1.00 177.02 ? 1074 ASP A OD2 1 
ATOM   1811 N N   . ALA A 1 311 ? -15.978 -11.458 -54.814 1.00 177.22 ? 1075 ALA A N   1 
ATOM   1812 C CA  . ALA A 1 311 ? -14.791 -12.057 -55.409 1.00 177.92 ? 1075 ALA A CA  1 
ATOM   1813 C C   . ALA A 1 311 ? -14.902 -13.576 -55.445 1.00 176.81 ? 1075 ALA A C   1 
ATOM   1814 O O   . ALA A 1 311 ? -14.522 -14.209 -56.434 1.00 192.07 ? 1075 ALA A O   1 
ATOM   1815 C CB  . ALA A 1 311 ? -13.546 -11.626 -54.635 1.00 192.51 ? 1075 ALA A CB  1 
ATOM   1816 N N   . LEU A 1 312 ? -15.415 -14.179 -54.370 1.00 197.58 ? 1076 LEU A N   1 
ATOM   1817 C CA  . LEU A 1 312 ? -15.619 -15.624 -54.361 1.00 189.90 ? 1076 LEU A CA  1 
ATOM   1818 C C   . LEU A 1 312 ? -16.612 -16.042 -55.437 1.00 192.49 ? 1076 LEU A C   1 
ATOM   1819 O O   . LEU A 1 312 ? -16.383 -17.022 -56.158 1.00 208.20 ? 1076 LEU A O   1 
ATOM   1820 C CB  . LEU A 1 312 ? -16.105 -16.076 -52.983 1.00 192.03 ? 1076 LEU A CB  1 
ATOM   1821 C CG  . LEU A 1 312 ? -15.050 -16.644 -52.032 1.00 194.84 ? 1076 LEU A CG  1 
ATOM   1822 C CD1 . LEU A 1 312 ? -15.648 -16.902 -50.655 1.00 196.75 ? 1076 LEU A CD1 1 
ATOM   1823 C CD2 . LEU A 1 312 ? -14.451 -17.922 -52.601 1.00 190.08 ? 1076 LEU A CD2 1 
ATOM   1824 N N   . LYS A 1 313 ? -17.722 -15.308 -55.563 1.00 206.03 ? 1077 LYS A N   1 
ATOM   1825 C CA  . LYS A 1 313 ? -18.701 -15.622 -56.598 1.00 203.80 ? 1077 LYS A CA  1 
ATOM   1826 C C   . LYS A 1 313 ? -18.045 -15.635 -57.969 1.00 183.44 ? 1077 LYS A C   1 
ATOM   1827 O O   . LYS A 1 313 ? -18.191 -16.595 -58.734 1.00 193.79 ? 1077 LYS A O   1 
ATOM   1828 C CB  . LYS A 1 313 ? -19.849 -14.611 -56.574 1.00 207.70 ? 1077 LYS A CB  1 
ATOM   1829 C CG  . LYS A 1 313 ? -20.937 -14.908 -57.603 1.00 208.14 ? 1077 LYS A CG  1 
ATOM   1830 C CD  . LYS A 1 313 ? -21.960 -13.789 -57.702 1.00 202.88 ? 1077 LYS A CD  1 
ATOM   1831 C CE  . LYS A 1 313 ? -23.175 -14.226 -58.511 1.00 184.46 ? 1077 LYS A CE  1 
ATOM   1832 N NZ  . LYS A 1 313 ? -22.807 -14.684 -59.882 1.00 195.01 ? 1077 LYS A NZ  1 
ATOM   1833 N N   . LEU A 1 314 ? -17.305 -14.573 -58.293 1.00 175.28 ? 1078 LEU A N   1 
ATOM   1834 C CA  . LEU A 1 314 ? -16.641 -14.523 -59.592 1.00 153.51 ? 1078 LEU A CA  1 
ATOM   1835 C C   . LEU A 1 314 ? -15.650 -15.671 -59.747 1.00 162.29 ? 1078 LEU A C   1 
ATOM   1836 O O   . LEU A 1 314 ? -15.616 -16.334 -60.789 1.00 187.35 ? 1078 LEU A O   1 
ATOM   1837 C CB  . LEU A 1 314 ? -15.942 -13.179 -59.767 1.00 161.99 ? 1078 LEU A CB  1 
ATOM   1838 C CG  . LEU A 1 314 ? -16.894 -11.985 -59.783 1.00 157.84 ? 1078 LEU A CG  1 
ATOM   1839 C CD1 . LEU A 1 314 ? -16.123 -10.684 -59.640 1.00 194.55 ? 1078 LEU A CD1 1 
ATOM   1840 C CD2 . LEU A 1 314 ? -17.721 -11.988 -61.058 1.00 170.30 ? 1078 LEU A CD2 1 
ATOM   1841 N N   . ALA A 1 315 ? -14.859 -15.943 -58.707 1.00 190.17 ? 1079 ALA A N   1 
ATOM   1842 C CA  . ALA A 1 315 ? -13.830 -16.972 -58.806 1.00 178.73 ? 1079 ALA A CA  1 
ATOM   1843 C C   . ALA A 1 315 ? -14.435 -18.339 -59.096 1.00 176.84 ? 1079 ALA A C   1 
ATOM   1844 O O   . ALA A 1 315 ? -13.894 -19.106 -59.902 1.00 184.81 ? 1079 ALA A O   1 
ATOM   1845 C CB  . ALA A 1 315 ? -13.013 -17.015 -57.514 1.00 196.72 ? 1079 ALA A CB  1 
ATOM   1846 N N   . ASN A 1 316 ? -15.555 -18.665 -58.448 1.00 190.76 ? 1080 ASN A N   1 
ATOM   1847 C CA  . ASN A 1 316 ? -16.117 -20.004 -58.591 1.00 192.31 ? 1080 ASN A CA  1 
ATOM   1848 C C   . ASN A 1 316 ? -16.534 -20.291 -60.030 1.00 207.32 ? 1080 ASN A C   1 
ATOM   1849 O O   . ASN A 1 316 ? -16.257 -21.374 -60.559 1.00 195.87 ? 1080 ASN A O   1 
ATOM   1850 C CB  . ASN A 1 316 ? -17.302 -20.176 -57.642 1.00 207.24 ? 1080 ASN A CB  1 
ATOM   1851 C CG  . ASN A 1 316 ? -16.870 -20.394 -56.204 1.00 234.23 ? 1080 ASN A CG  1 
ATOM   1852 O OD1 . ASN A 1 316 ? -16.880 -21.518 -55.704 1.00 270.30 ? 1080 ASN A OD1 1 
ATOM   1853 N ND2 . ASN A 1 316 ? -16.478 -19.317 -55.534 1.00 214.60 ? 1080 ASN A ND2 1 
ATOM   1854 N N   . GLU A 1 317 ? -17.195 -19.338 -60.683 1.00 173.48 ? 1081 GLU A N   1 
ATOM   1855 C CA  . GLU A 1 317 ? -17.711 -19.555 -62.036 1.00 184.43 ? 1081 GLU A CA  1 
ATOM   1856 C C   . GLU A 1 317 ? -16.687 -19.174 -63.100 1.00 175.14 ? 1081 GLU A C   1 
ATOM   1857 O O   . GLU A 1 317 ? -16.965 -18.393 -64.009 1.00 175.98 ? 1081 GLU A O   1 
ATOM   1858 C CB  . GLU A 1 317 ? -19.014 -18.786 -62.230 1.00 198.41 ? 1081 GLU A CB  1 
ATOM   1859 C CG  . GLU A 1 317 ? -18.939 -17.302 -61.913 1.00 152.64 ? 1081 GLU A CG  1 
ATOM   1860 C CD  . GLU A 1 317 ? -20.262 -16.597 -62.141 1.00 169.39 ? 1081 GLU A CD  1 
ATOM   1861 O OE1 . GLU A 1 317 ? -21.053 -17.071 -62.985 1.00 197.59 ? 1081 GLU A OE1 1 
ATOM   1862 O OE2 . GLU A 1 317 ? -20.514 -15.573 -61.472 1.00 172.48 ? 1081 GLU A OE2 1 
ATOM   1863 N N   . GLY A 1 318 ? -15.488 -19.744 -62.986 1.00 207.41 ? 1082 GLY A N   1 
ATOM   1864 C CA  . GLY A 1 318 ? -14.436 -19.552 -63.967 1.00 177.99 ? 1082 GLY A CA  1 
ATOM   1865 C C   . GLY A 1 318 ? -14.251 -18.116 -64.410 1.00 191.52 ? 1082 GLY A C   1 
ATOM   1866 O O   . GLY A 1 318 ? -14.487 -17.795 -65.577 1.00 211.67 ? 1082 GLY A O   1 
ATOM   1867 N N   . LYS A 1 319 ? -13.835 -17.238 -63.501 1.00 181.14 ? 1083 LYS A N   1 
ATOM   1868 C CA  . LYS A 1 319 ? -13.650 -15.824 -63.824 1.00 163.20 ? 1083 LYS A CA  1 
ATOM   1869 C C   . LYS A 1 319 ? -12.320 -15.322 -63.265 1.00 202.13 ? 1083 LYS A C   1 
ATOM   1870 O O   . LYS A 1 319 ? -12.230 -14.246 -62.672 1.00 202.86 ? 1083 LYS A O   1 
ATOM   1871 C CB  . LYS A 1 319 ? -14.835 -14.999 -63.319 1.00 184.76 ? 1083 LYS A CB  1 
ATOM   1872 C CG  . LYS A 1 319 ? -14.936 -13.564 -63.867 1.00 189.55 ? 1083 LYS A CG  1 
ATOM   1873 C CD  . LYS A 1 319 ? -14.360 -13.390 -65.275 1.00 204.28 ? 1083 LYS A CD  1 
ATOM   1874 C CE  . LYS A 1 319 ? -14.878 -12.134 -65.976 1.00 199.48 ? 1083 LYS A CE  1 
ATOM   1875 N NZ  . LYS A 1 319 ? -14.380 -12.002 -67.374 1.00 194.28 ? 1083 LYS A NZ  1 
ATOM   1876 N N   . VAL A 1 320 ? -11.249 -16.087 -63.513 1.00 180.95 ? 1084 VAL A N   1 
ATOM   1877 C CA  . VAL A 1 320 ? -9.989  -15.893 -62.792 1.00 186.16 ? 1084 VAL A CA  1 
ATOM   1878 C C   . VAL A 1 320 ? -9.491  -14.458 -62.929 1.00 197.95 ? 1084 VAL A C   1 
ATOM   1879 O O   . VAL A 1 320 ? -9.156  -13.801 -61.934 1.00 198.95 ? 1084 VAL A O   1 
ATOM   1880 C CB  . VAL A 1 320 ? -8.930  -16.894 -63.292 1.00 176.20 ? 1084 VAL A CB  1 
ATOM   1881 C CG1 . VAL A 1 320 ? -7.578  -16.620 -62.641 1.00 196.17 ? 1084 VAL A CG1 1 
ATOM   1882 C CG2 . VAL A 1 320 ? -9.373  -18.325 -63.023 1.00 201.49 ? 1084 VAL A CG2 1 
ATOM   1883 N N   . LYS A 1 321 ? -9.424  -13.950 -64.161 1.00 186.85 ? 1085 LYS A N   1 
ATOM   1884 C CA  . LYS A 1 321 ? -8.819  -12.639 -64.378 1.00 178.29 ? 1085 LYS A CA  1 
ATOM   1885 C C   . LYS A 1 321 ? -9.567  -11.557 -63.601 1.00 186.90 ? 1085 LYS A C   1 
ATOM   1886 O O   . LYS A 1 321 ? -8.966  -10.747 -62.875 1.00 203.00 ? 1085 LYS A O   1 
ATOM   1887 C CB  . LYS A 1 321 ? -8.797  -12.327 -65.875 1.00 189.61 ? 1085 LYS A CB  1 
ATOM   1888 N N   . GLU A 1 322 ? -10.893 -11.560 -63.699 1.00 211.80 ? 1086 GLU A N   1 
ATOM   1889 C CA  . GLU A 1 322 ? -11.684 -10.549 -63.011 1.00 207.73 ? 1086 GLU A CA  1 
ATOM   1890 C C   . GLU A 1 322 ? -11.786 -10.822 -61.514 1.00 212.59 ? 1086 GLU A C   1 
ATOM   1891 O O   . GLU A 1 322 ? -11.939 -9.880  -60.730 1.00 210.76 ? 1086 GLU A O   1 
ATOM   1892 C CB  . GLU A 1 322 ? -13.071 -10.471 -63.644 1.00 203.48 ? 1086 GLU A CB  1 
ATOM   1893 C CG  . GLU A 1 322 ? -14.018 -9.469  -63.016 1.00 215.50 ? 1086 GLU A CG  1 
ATOM   1894 C CD  . GLU A 1 322 ? -13.721 -8.047  -63.439 1.00 221.60 ? 1086 GLU A CD  1 
ATOM   1895 O OE1 . GLU A 1 322 ? -12.853 -7.853  -64.317 1.00 202.47 ? 1086 GLU A OE1 1 
ATOM   1896 O OE2 . GLU A 1 322 ? -14.358 -7.122  -62.893 1.00 275.67 ? 1086 GLU A OE2 1 
ATOM   1897 N N   . ALA A 1 323 ? -11.707 -12.086 -61.092 1.00 202.51 ? 1087 ALA A N   1 
ATOM   1898 C CA  . ALA A 1 323 ? -11.657 -12.367 -59.660 1.00 200.66 ? 1087 ALA A CA  1 
ATOM   1899 C C   . ALA A 1 323 ? -10.408 -11.760 -59.034 1.00 191.84 ? 1087 ALA A C   1 
ATOM   1900 O O   . ALA A 1 323 ? -10.465 -11.182 -57.941 1.00 178.09 ? 1087 ALA A O   1 
ATOM   1901 C CB  . ALA A 1 323 ? -11.703 -13.875 -59.414 1.00 192.07 ? 1087 ALA A CB  1 
ATOM   1902 N N   . GLN A 1 324 ? -9.268  -11.876 -59.717 1.00 205.76 ? 1088 GLN A N   1 
ATOM   1903 C CA  . GLN A 1 324 ? -8.057  -11.220 -59.238 1.00 178.23 ? 1088 GLN A CA  1 
ATOM   1904 C C   . GLN A 1 324 ? -8.220  -9.705  -59.229 1.00 185.58 ? 1088 GLN A C   1 
ATOM   1905 O O   . GLN A 1 324 ? -7.765  -9.026  -58.298 1.00 182.84 ? 1088 GLN A O   1 
ATOM   1906 C CB  . GLN A 1 324 ? -6.869  -11.633 -60.103 1.00 178.03 ? 1088 GLN A CB  1 
ATOM   1907 C CG  . GLN A 1 324 ? -6.509  -13.104 -59.979 1.00 163.52 ? 1088 GLN A CG  1 
ATOM   1908 C CD  . GLN A 1 324 ? -5.567  -13.569 -61.070 1.00 149.18 ? 1088 GLN A CD  1 
ATOM   1909 O OE1 . GLN A 1 324 ? -5.586  -13.050 -62.184 1.00 176.43 ? 1088 GLN A OE1 1 
ATOM   1910 N NE2 . GLN A 1 324 ? -4.733  -14.551 -60.753 1.00 148.48 ? 1088 GLN A NE2 1 
ATOM   1911 N N   . ALA A 1 325 ? -8.870  -9.152  -60.257 1.00 193.10 ? 1089 ALA A N   1 
ATOM   1912 C CA  . ALA A 1 325 ? -9.111  -7.709  -60.253 1.00 186.09 ? 1089 ALA A CA  1 
ATOM   1913 C C   . ALA A 1 325 ? -9.948  -7.289  -59.047 1.00 179.35 ? 1089 ALA A C   1 
ATOM   1914 O O   . ALA A 1 325 ? -9.686  -6.250  -58.430 1.00 187.42 ? 1089 ALA A O   1 
ATOM   1915 C CB  . ALA A 1 325 ? -9.793  -7.282  -61.551 1.00 214.03 ? 1089 ALA A CB  1 
ATOM   1916 N N   . ALA A 1 326 ? -10.973 -8.075  -58.707 1.00 182.74 ? 1090 ALA A N   1 
ATOM   1917 C CA  . ALA A 1 326 ? -11.789 -7.771  -57.533 1.00 201.71 ? 1090 ALA A CA  1 
ATOM   1918 C C   . ALA A 1 326 ? -10.973 -7.882  -56.250 1.00 194.91 ? 1090 ALA A C   1 
ATOM   1919 O O   . ALA A 1 326 ? -11.123 -7.062  -55.333 1.00 212.48 ? 1090 ALA A O   1 
ATOM   1920 C CB  . ALA A 1 326 ? -12.999 -8.704  -57.480 1.00 210.98 ? 1090 ALA A CB  1 
ATOM   1921 N N   . ALA A 1 327 ? -10.116 -8.901  -56.158 1.00 196.80 ? 1091 ALA A N   1 
ATOM   1922 C CA  . ALA A 1 327 ? -9.232  -9.011  -55.004 1.00 172.84 ? 1091 ALA A CA  1 
ATOM   1923 C C   . ALA A 1 327 ? -8.322  -7.797  -54.894 1.00 161.55 ? 1091 ALA A C   1 
ATOM   1924 O O   . ALA A 1 327 ? -7.908  -7.427  -53.790 1.00 180.89 ? 1091 ALA A O   1 
ATOM   1925 C CB  . ALA A 1 327 ? -8.400  -10.290 -55.092 1.00 163.85 ? 1091 ALA A CB  1 
ATOM   1926 N N   . GLU A 1 328 ? -7.983  -7.179  -56.026 1.00 171.38 ? 1092 GLU A N   1 
ATOM   1927 C CA  . GLU A 1 328 ? -7.215  -5.937  -55.979 1.00 168.06 ? 1092 GLU A CA  1 
ATOM   1928 C C   . GLU A 1 328 ? -8.078  -4.769  -55.512 1.00 176.90 ? 1092 GLU A C   1 
ATOM   1929 O O   . GLU A 1 328 ? -7.638  -3.954  -54.693 1.00 208.75 ? 1092 GLU A O   1 
ATOM   1930 C CB  . GLU A 1 328 ? -6.608  -5.639  -57.347 1.00 168.93 ? 1092 GLU A CB  1 
ATOM   1931 C CG  . GLU A 1 328 ? -5.503  -6.598  -57.754 1.00 176.15 ? 1092 GLU A CG  1 
ATOM   1932 C CD  . GLU A 1 328 ? -4.303  -6.530  -56.833 1.00 171.08 ? 1092 GLU A CD  1 
ATOM   1933 O OE1 . GLU A 1 328 ? -4.201  -5.556  -56.057 1.00 175.55 ? 1092 GLU A OE1 1 
ATOM   1934 O OE2 . GLU A 1 328 ? -3.463  -7.453  -56.882 1.00 171.19 ? 1092 GLU A OE2 1 
ATOM   1935 N N   . GLN A 1 329 ? -9.308  -4.667  -56.025 1.00 196.10 ? 1093 GLN A N   1 
ATOM   1936 C CA  . GLN A 1 329 ? -10.207 -3.610  -55.564 1.00 184.20 ? 1093 GLN A CA  1 
ATOM   1937 C C   . GLN A 1 329 ? -10.420 -3.698  -54.061 1.00 191.15 ? 1093 GLN A C   1 
ATOM   1938 O O   . GLN A 1 329 ? -10.673 -2.679  -53.406 1.00 177.87 ? 1093 GLN A O   1 
ATOM   1939 C CB  . GLN A 1 329 ? -11.559 -3.683  -56.276 1.00 202.60 ? 1093 GLN A CB  1 
ATOM   1940 C CG  . GLN A 1 329 ? -11.482 -3.772  -57.788 1.00 202.41 ? 1093 GLN A CG  1 
ATOM   1941 C CD  . GLN A 1 329 ? -10.393 -2.901  -58.374 1.00 205.85 ? 1093 GLN A CD  1 
ATOM   1942 O OE1 . GLN A 1 329 ? -10.342 -1.696  -58.124 1.00 203.60 ? 1093 GLN A OE1 1 
ATOM   1943 N NE2 . GLN A 1 329 ? -9.506  -3.510  -59.154 1.00 186.91 ? 1093 GLN A NE2 1 
ATOM   1944 N N   . LEU A 1 330 ? -10.327 -4.908  -53.503 1.00 192.49 ? 1094 LEU A N   1 
ATOM   1945 C CA  . LEU A 1 330 ? -10.389 -5.066  -52.055 1.00 169.72 ? 1094 LEU A CA  1 
ATOM   1946 C C   . LEU A 1 330 ? -9.352  -4.215  -51.337 1.00 163.99 ? 1094 LEU A C   1 
ATOM   1947 O O   . LEU A 1 330 ? -9.490  -3.986  -50.134 1.00 191.60 ? 1094 LEU A O   1 
ATOM   1948 C CB  . LEU A 1 330 ? -10.172 -6.527  -51.652 1.00 171.25 ? 1094 LEU A CB  1 
ATOM   1949 C CG  . LEU A 1 330 ? -11.271 -7.550  -51.932 1.00 187.56 ? 1094 LEU A CG  1 
ATOM   1950 C CD1 . LEU A 1 330 ? -10.800 -8.934  -51.508 1.00 181.09 ? 1094 LEU A CD1 1 
ATOM   1951 C CD2 . LEU A 1 330 ? -12.553 -7.180  -51.208 1.00 189.29 ? 1094 LEU A CD2 1 
ATOM   1952 N N   . LYS A 1 331 ? -8.306  -3.765  -52.037 1.00 170.17 ? 1095 LYS A N   1 
ATOM   1953 C CA  . LYS A 1 331 ? -7.237  -3.021  -51.378 1.00 137.68 ? 1095 LYS A CA  1 
ATOM   1954 C C   . LYS A 1 331 ? -7.749  -1.713  -50.785 1.00 156.87 ? 1095 LYS A C   1 
ATOM   1955 O O   . LYS A 1 331 ? -7.351  -1.332  -49.679 1.00 174.05 ? 1095 LYS A O   1 
ATOM   1956 C CB  . LYS A 1 331 ? -6.102  -2.751  -52.365 1.00 161.07 ? 1095 LYS A CB  1 
ATOM   1957 N N   . THR A 1 332 ? -8.626  -1.006  -51.502 1.00 187.32 ? 1096 THR A N   1 
ATOM   1958 C CA  . THR A 1 332 ? -9.136  0.268   -51.000 1.00 196.68 ? 1096 THR A CA  1 
ATOM   1959 C C   . THR A 1 332 ? -9.923  0.073   -49.704 1.00 185.63 ? 1096 THR A C   1 
ATOM   1960 O O   . THR A 1 332 ? -9.674  0.750   -48.692 1.00 193.03 ? 1096 THR A O   1 
ATOM   1961 C CB  . THR A 1 332 ? -10.011 0.934   -52.067 1.00 202.50 ? 1096 THR A CB  1 
ATOM   1962 O OG1 . THR A 1 332 ? -11.219 0.182   -52.242 1.00 192.75 ? 1096 THR A OG1 1 
ATOM   1963 C CG2 . THR A 1 332 ? -9.277  1.009   -53.404 1.00 175.06 ? 1096 THR A CG2 1 
ATOM   1964 N N   . THR A 1 333 ? -10.877 -0.861  -49.716 1.00 175.70 ? 1097 THR A N   1 
ATOM   1965 C CA  . THR A 1 333 ? -11.670 -1.129  -48.522 1.00 185.15 ? 1097 THR A CA  1 
ATOM   1966 C C   . THR A 1 333 ? -10.815 -1.699  -47.396 1.00 178.13 ? 1097 THR A C   1 
ATOM   1967 O O   . THR A 1 333 ? -11.070 -1.412  -46.222 1.00 206.22 ? 1097 THR A O   1 
ATOM   1968 C CB  . THR A 1 333 ? -12.816 -2.084  -48.858 1.00 183.31 ? 1097 THR A CB  1 
ATOM   1969 O OG1 . THR A 1 333 ? -12.285 -3.304  -49.389 1.00 188.49 ? 1097 THR A OG1 1 
ATOM   1970 C CG2 . THR A 1 333 ? -13.759 -1.451  -49.880 1.00 179.15 ? 1097 THR A CG2 1 
ATOM   1971 N N   . ARG A 1 334 ? -9.801  -2.502  -47.727 1.00 149.87 ? 1098 ARG A N   1 
ATOM   1972 C CA  . ARG A 1 334 ? -8.897  -3.016  -46.705 1.00 183.48 ? 1098 ARG A CA  1 
ATOM   1973 C C   . ARG A 1 334 ? -8.111  -1.887  -46.051 1.00 170.94 ? 1098 ARG A C   1 
ATOM   1974 O O   . ARG A 1 334 ? -7.921  -1.882  -44.831 1.00 191.24 ? 1098 ARG A O   1 
ATOM   1975 C CB  . ARG A 1 334 ? -7.953  -4.050  -47.320 1.00 175.49 ? 1098 ARG A CB  1 
ATOM   1976 C CG  . ARG A 1 334 ? -6.948  -4.645  -46.344 1.00 170.32 ? 1098 ARG A CG  1 
ATOM   1977 C CD  . ARG A 1 334 ? -5.539  -4.093  -46.551 1.00 175.67 ? 1098 ARG A CD  1 
ATOM   1978 N NE  . ARG A 1 334 ? -4.859  -4.697  -47.693 1.00 174.12 ? 1098 ARG A NE  1 
ATOM   1979 C CZ  . ARG A 1 334 ? -3.578  -4.514  -47.989 1.00 154.97 ? 1098 ARG A CZ  1 
ATOM   1980 N NH1 . ARG A 1 334 ? -2.798  -3.748  -47.245 1.00 151.40 ? 1098 ARG A NH1 1 
ATOM   1981 N NH2 . ARG A 1 334 ? -3.066  -5.116  -49.058 1.00 154.45 ? 1098 ARG A NH2 1 
ATOM   1982 N N   . ASN A 1 335 ? -7.642  -0.922  -46.847 1.00 178.95 ? 1099 ASN A N   1 
ATOM   1983 C CA  . ASN A 1 335 ? -6.966  0.240   -46.281 1.00 188.04 ? 1099 ASN A CA  1 
ATOM   1984 C C   . ASN A 1 335 ? -7.893  0.992   -45.335 1.00 202.61 ? 1099 ASN A C   1 
ATOM   1985 O O   . ASN A 1 335 ? -7.504  1.360   -44.218 1.00 186.24 ? 1099 ASN A O   1 
ATOM   1986 C CB  . ASN A 1 335 ? -6.481  1.168   -47.398 1.00 220.00 ? 1099 ASN A CB  1 
ATOM   1987 C CG  . ASN A 1 335 ? -5.435  0.522   -48.287 1.00 221.21 ? 1099 ASN A CG  1 
ATOM   1988 O OD1 . ASN A 1 335 ? -4.833  -0.490  -47.925 1.00 189.17 ? 1099 ASN A OD1 1 
ATOM   1989 N ND2 . ASN A 1 335 ? -5.206  1.113   -49.457 1.00 217.33 ? 1099 ASN A ND2 1 
ATOM   1990 N N   . ALA A 1 336 ? -9.137  1.218   -45.765 1.00 196.94 ? 1100 ALA A N   1 
ATOM   1991 C CA  . ALA A 1 336 ? -10.088 1.915   -44.904 1.00 182.65 ? 1100 ALA A CA  1 
ATOM   1992 C C   . ALA A 1 336 ? -10.295 1.161   -43.591 1.00 181.00 ? 1100 ALA A C   1 
ATOM   1993 O O   . ALA A 1 336 ? -10.227 1.748   -42.503 1.00 197.74 ? 1100 ALA A O   1 
ATOM   1994 C CB  . ALA A 1 336 ? -11.416 2.104   -45.637 1.00 190.09 ? 1100 ALA A CB  1 
ATOM   1995 N N   . TYR A 1 337 ? -10.526 -0.152  -43.672 1.00 189.14 ? 1101 TYR A N   1 
ATOM   1996 C CA  . TYR A 1 337 ? -10.815 -0.937  -42.472 1.00 177.64 ? 1101 TYR A CA  1 
ATOM   1997 C C   . TYR A 1 337 ? -9.619  -0.987  -41.523 1.00 192.09 ? 1101 TYR A C   1 
ATOM   1998 O O   . TYR A 1 337 ? -9.782  -0.887  -40.295 1.00 180.57 ? 1101 TYR A O   1 
ATOM   1999 C CB  . TYR A 1 337 ? -11.240 -2.351  -42.872 1.00 155.25 ? 1101 TYR A CB  1 
ATOM   2000 N N   . ILE A 1 338 ? -8.414  -1.175  -42.068 1.00 201.78 ? 1102 ILE A N   1 
ATOM   2001 C CA  . ILE A 1 338 ? -7.228  -1.252  -41.222 1.00 194.88 ? 1102 ILE A CA  1 
ATOM   2002 C C   . ILE A 1 338 ? -6.973  0.092   -40.556 1.00 181.38 ? 1102 ILE A C   1 
ATOM   2003 O O   . ILE A 1 338 ? -6.582  0.153   -39.384 1.00 180.12 ? 1102 ILE A O   1 
ATOM   2004 C CB  . ILE A 1 338 ? -6.015  -1.736  -42.040 1.00 201.47 ? 1102 ILE A CB  1 
ATOM   2005 C CG1 . ILE A 1 338 ? -4.839  -2.070  -41.119 1.00 213.56 ? 1102 ILE A CG1 1 
ATOM   2006 C CG2 . ILE A 1 338 ? -5.591  -0.697  -43.065 1.00 207.95 ? 1102 ILE A CG2 1 
ATOM   2007 C CD1 . ILE A 1 338 ? -5.078  -3.278  -40.240 1.00 207.55 ? 1102 ILE A CD1 1 
ATOM   2008 N N   . GLN A 1 339 ? -7.199  1.193   -41.279 1.00 190.87 ? 1103 GLN A N   1 
ATOM   2009 C CA  . GLN A 1 339 ? -7.146  2.500   -40.634 1.00 190.61 ? 1103 GLN A CA  1 
ATOM   2010 C C   . GLN A 1 339 ? -8.174  2.589   -39.513 1.00 179.25 ? 1103 GLN A C   1 
ATOM   2011 O O   . GLN A 1 339 ? -7.922  3.213   -38.476 1.00 157.19 ? 1103 GLN A O   1 
ATOM   2012 C CB  . GLN A 1 339 ? -7.376  3.604   -41.666 1.00 190.35 ? 1103 GLN A CB  1 
ATOM   2013 N N   . LYS A 1 340 ? -9.340  1.970   -39.705 1.00 174.26 ? 1104 LYS A N   1 
ATOM   2014 C CA  . LYS A 1 340 ? -10.398 2.053   -38.702 1.00 182.65 ? 1104 LYS A CA  1 
ATOM   2015 C C   . LYS A 1 340 ? -9.991  1.384   -37.391 1.00 178.04 ? 1104 LYS A C   1 
ATOM   2016 O O   . LYS A 1 340 ? -10.049 2.001   -36.321 1.00 192.58 ? 1104 LYS A O   1 
ATOM   2017 C CB  . LYS A 1 340 ? -11.677 1.416   -39.250 1.00 169.51 ? 1104 LYS A CB  1 
ATOM   2018 N N   . TYR A 1 341 ? -9.561  0.121   -37.455 1.00 184.73 ? 1105 TYR A N   1 
ATOM   2019 C CA  . TYR A 1 341 ? -9.418  -0.654  -36.217 1.00 154.03 ? 1105 TYR A CA  1 
ATOM   2020 C C   . TYR A 1 341 ? -8.367  -0.065  -35.281 1.00 148.20 ? 1105 TYR A C   1 
ATOM   2021 O O   . TYR A 1 341 ? -8.449  -0.245  -34.055 1.00 137.70 ? 1105 TYR A O   1 
ATOM   2022 C CB  . TYR A 1 341 ? -9.067  -2.109  -36.519 1.00 166.77 ? 1105 TYR A CB  1 
ATOM   2023 C CG  . TYR A 1 341 ? -10.226 -2.913  -37.049 1.00 186.13 ? 1105 TYR A CG  1 
ATOM   2024 C CD1 . TYR A 1 341 ? -11.115 -3.548  -36.188 1.00 178.97 ? 1105 TYR A CD1 1 
ATOM   2025 C CD2 . TYR A 1 341 ? -10.434 -3.037  -38.413 1.00 193.94 ? 1105 TYR A CD2 1 
ATOM   2026 C CE1 . TYR A 1 341 ? -12.179 -4.285  -36.678 1.00 216.21 ? 1105 TYR A CE1 1 
ATOM   2027 C CE2 . TYR A 1 341 ? -11.491 -3.767  -38.912 1.00 220.22 ? 1105 TYR A CE2 1 
ATOM   2028 C CZ  . TYR A 1 341 ? -12.362 -4.390  -38.042 1.00 220.17 ? 1105 TYR A CZ  1 
ATOM   2029 O OH  . TYR A 1 341 ? -13.415 -5.119  -38.545 1.00 223.11 ? 1105 TYR A OH  1 
ATOM   2030 N N   . LEU A 1 342 ? -7.365  0.618   -35.835 1.00 138.69 ? 1106 LEU A N   1 
ATOM   2031 C CA  . LEU A 1 342 ? -6.304  1.176   -35.005 1.00 145.74 ? 1106 LEU A CA  1 
ATOM   2032 C C   . LEU A 1 342 ? -6.850  2.221   -34.042 1.00 154.94 ? 1106 LEU A C   1 
ATOM   2033 O O   . LEU A 1 342 ? -6.438  2.279   -32.878 1.00 169.03 ? 1106 LEU A O   1 
ATOM   2034 C CB  . LEU A 1 342 ? -5.218  1.779   -35.891 1.00 177.67 ? 1106 LEU A CB  1 
ATOM   2035 C CG  . LEU A 1 342 ? -4.596  0.800   -36.887 1.00 157.49 ? 1106 LEU A CG  1 
ATOM   2036 C CD1 . LEU A 1 342 ? -3.647  1.526   -37.831 1.00 174.78 ? 1106 LEU A CD1 1 
ATOM   2037 C CD2 . LEU A 1 342 ? -3.879  -0.326  -36.160 1.00 174.45 ? 1106 LEU A CD2 1 
ATOM   2038 N N   . ALA A 1 343 ? -7.770  3.065   -34.511 1.00 156.28 ? 900  ALA A N   1 
ATOM   2039 C CA  . ALA A 1 343 ? -8.380  4.048   -33.624 1.00 165.75 ? 900  ALA A CA  1 
ATOM   2040 C C   . ALA A 1 343 ? -9.142  3.361   -32.501 1.00 180.53 ? 900  ALA A C   1 
ATOM   2041 O O   . ALA A 1 343 ? -9.114  3.813   -31.348 1.00 171.45 ? 900  ALA A O   1 
ATOM   2042 C CB  . ALA A 1 343 ? -9.309  4.966   -34.417 1.00 173.96 ? 900  ALA A CB  1 
ATOM   2043 N N   . HIS A 1 344 ? -9.832  2.266   -32.820 1.00 174.64 ? 270  HIS A N   1 
ATOM   2044 C CA  . HIS A 1 344 ? -10.549 1.529   -31.789 1.00 166.92 ? 270  HIS A CA  1 
ATOM   2045 C C   . HIS A 1 344 ? -9.593  1.022   -30.718 1.00 166.43 ? 270  HIS A C   1 
ATOM   2046 O O   . HIS A 1 344 ? -9.849  1.164   -29.514 1.00 167.89 ? 270  HIS A O   1 
ATOM   2047 C CB  . HIS A 1 344 ? -11.308 0.359   -32.409 1.00 153.89 ? 270  HIS A CB  1 
ATOM   2048 C CG  . HIS A 1 344 ? -11.978 -0.501  -31.392 1.00 162.40 ? 270  HIS A CG  1 
ATOM   2049 N ND1 . HIS A 1 344 ? -12.749 0.029   -30.381 1.00 183.66 ? 270  HIS A ND1 1 
ATOM   2050 C CD2 . HIS A 1 344 ? -11.970 -1.841  -31.200 1.00 168.33 ? 270  HIS A CD2 1 
ATOM   2051 C CE1 . HIS A 1 344 ? -13.192 -0.948  -29.613 1.00 193.99 ? 270  HIS A CE1 1 
ATOM   2052 N NE2 . HIS A 1 344 ? -12.741 -2.094  -30.093 1.00 192.86 ? 270  HIS A NE2 1 
ATOM   2053 N N   . LEU A 1 345 ? -8.483  0.418   -31.141 1.00 145.90 ? 271  LEU A N   1 
ATOM   2054 C CA  . LEU A 1 345 ? -7.538  -0.099  -30.156 1.00 147.48 ? 271  LEU A CA  1 
ATOM   2055 C C   . LEU A 1 345 ? -6.888  1.025   -29.356 1.00 147.80 ? 271  LEU A C   1 
ATOM   2056 O O   . LEU A 1 345 ? -6.609  0.853   -28.164 1.00 157.74 ? 271  LEU A O   1 
ATOM   2057 C CB  . LEU A 1 345 ? -6.485  -0.968  -30.837 1.00 126.78 ? 271  LEU A CB  1 
ATOM   2058 C CG  . LEU A 1 345 ? -6.857  -2.452  -30.768 1.00 151.69 ? 271  LEU A CG  1 
ATOM   2059 C CD1 . LEU A 1 345 ? -8.200  -2.709  -31.454 1.00 153.54 ? 271  LEU A CD1 1 
ATOM   2060 C CD2 . LEU A 1 345 ? -5.764  -3.322  -31.363 1.00 173.48 ? 271  LEU A CD2 1 
ATOM   2061 N N   . ALA A 1 346 ? -6.653  2.181   -29.980 1.00 161.99 ? 272  ALA A N   1 
ATOM   2062 C CA  . ALA A 1 346 ? -6.137  3.324   -29.234 1.00 131.51 ? 272  ALA A CA  1 
ATOM   2063 C C   . ALA A 1 346 ? -7.122  3.765   -28.157 1.00 139.18 ? 272  ALA A C   1 
ATOM   2064 O O   . ALA A 1 346 ? -6.726  4.061   -27.022 1.00 160.49 ? 272  ALA A O   1 
ATOM   2065 C CB  . ALA A 1 346 ? -5.836  4.479   -30.189 1.00 164.67 ? 272  ALA A CB  1 
ATOM   2066 N N   . ALA A 1 347 ? -8.413  3.814   -28.494 1.00 132.31 ? 273  ALA A N   1 
ATOM   2067 C CA  . ALA A 1 347 ? -9.417  4.186   -27.501 1.00 152.72 ? 273  ALA A CA  1 
ATOM   2068 C C   . ALA A 1 347 ? -9.466  3.172   -26.365 1.00 143.41 ? 273  ALA A C   1 
ATOM   2069 O O   . ALA A 1 347 ? -9.608  3.542   -25.190 1.00 158.57 ? 273  ALA A O   1 
ATOM   2070 C CB  . ALA A 1 347 ? -10.788 4.311   -28.162 1.00 156.96 ? 273  ALA A CB  1 
ATOM   2071 N N   . THR A 1 348 ? -9.368  1.885   -26.697 1.00 147.00 ? 274  THR A N   1 
ATOM   2072 C CA  . THR A 1 348 ? -9.338  0.862   -25.658 1.00 149.79 ? 274  THR A CA  1 
ATOM   2073 C C   . THR A 1 348 ? -8.145  1.070   -24.734 1.00 138.07 ? 274  THR A C   1 
ATOM   2074 O O   . THR A 1 348 ? -8.273  1.003   -23.503 1.00 135.76 ? 274  THR A O   1 
ATOM   2075 C CB  . THR A 1 348 ? -9.288  -0.528  -26.292 1.00 140.78 ? 274  THR A CB  1 
ATOM   2076 O OG1 . THR A 1 348 ? -10.528 -0.799  -26.956 1.00 171.26 ? 274  THR A OG1 1 
ATOM   2077 C CG2 . THR A 1 348 ? -9.040  -1.588  -25.235 1.00 145.13 ? 274  THR A CG2 1 
ATOM   2078 N N   . ARG A 1 349 ? -6.972  1.325   -25.316 1.00 107.41 ? 275  ARG A N   1 
ATOM   2079 C CA  . ARG A 1 349 ? -5.793  1.585   -24.503 1.00 107.41 ? 275  ARG A CA  1 
ATOM   2080 C C   . ARG A 1 349 ? -6.023  2.781   -23.594 1.00 115.28 ? 275  ARG A C   1 
ATOM   2081 O O   . ARG A 1 349 ? -5.644  2.758   -22.420 1.00 145.98 ? 275  ARG A O   1 
ATOM   2082 C CB  . ARG A 1 349 ? -4.577  1.816   -25.399 1.00 107.41 ? 275  ARG A CB  1 
ATOM   2083 N N   . LYS A 1 350 ? -6.657  3.831   -24.114 1.00 107.41 ? 276  LYS A N   1 
ATOM   2084 C CA  . LYS A 1 350 ? -6.916  5.013   -23.298 1.00 133.71 ? 276  LYS A CA  1 
ATOM   2085 C C   . LYS A 1 350 ? -7.816  4.677   -22.114 1.00 139.80 ? 276  LYS A C   1 
ATOM   2086 O O   . LYS A 1 350 ? -7.544  5.076   -20.973 1.00 146.49 ? 276  LYS A O   1 
ATOM   2087 C CB  . LYS A 1 350 ? -7.547  6.110   -24.155 1.00 136.52 ? 276  LYS A CB  1 
ATOM   2088 N N   . GLY A 1 351 ? -8.902  3.947   -22.367 1.00 107.41 ? 277  GLY A N   1 
ATOM   2089 C CA  . GLY A 1 351 ? -9.815  3.614   -21.283 1.00 159.53 ? 277  GLY A CA  1 
ATOM   2090 C C   . GLY A 1 351 ? -9.154  2.763   -20.216 1.00 127.29 ? 277  GLY A C   1 
ATOM   2091 O O   . GLY A 1 351 ? -9.298  3.016   -19.012 1.00 132.68 ? 277  GLY A O   1 
ATOM   2092 N N   . VAL A 1 352 ? -8.405  1.748   -20.643 1.00 126.71 ? 278  VAL A N   1 
ATOM   2093 C CA  . VAL A 1 352 ? -7.724  0.884   -19.687 1.00 119.06 ? 278  VAL A CA  1 
ATOM   2094 C C   . VAL A 1 352 ? -6.676  1.672   -18.913 1.00 131.95 ? 278  VAL A C   1 
ATOM   2095 O O   . VAL A 1 352 ? -6.462  1.447   -17.715 1.00 141.16 ? 278  VAL A O   1 
ATOM   2096 C CB  . VAL A 1 352 ? -7.108  -0.324  -20.413 1.00 124.49 ? 278  VAL A CB  1 
ATOM   2097 C CG1 . VAL A 1 352 ? -6.234  -1.125  -19.466 1.00 121.23 ? 278  VAL A CG1 1 
ATOM   2098 C CG2 . VAL A 1 352 ? -8.210  -1.196  -21.006 1.00 125.45 ? 278  VAL A CG2 1 
ATOM   2099 N N   . ARG A 1 353 ? -6.003  2.604   -19.583 1.00 107.41 ? 279  ARG A N   1 
ATOM   2100 C CA  . ARG A 1 353 ? -5.013  3.428   -18.904 1.00 134.08 ? 279  ARG A CA  1 
ATOM   2101 C C   . ARG A 1 353 ? -5.663  4.281   -17.824 1.00 126.44 ? 279  ARG A C   1 
ATOM   2102 O O   . ARG A 1 353 ? -5.117  4.430   -16.722 1.00 137.43 ? 279  ARG A O   1 
ATOM   2103 C CB  . ARG A 1 353 ? -4.292  4.295   -19.934 1.00 142.07 ? 279  ARG A CB  1 
ATOM   2104 C CG  . ARG A 1 353 ? -3.231  5.209   -19.357 1.00 173.02 ? 279  ARG A CG  1 
ATOM   2105 C CD  . ARG A 1 353 ? -2.233  4.429   -18.526 1.00 187.05 ? 279  ARG A CD  1 
ATOM   2106 N NE  . ARG A 1 353 ? -1.653  3.326   -19.283 1.00 187.48 ? 279  ARG A NE  1 
ATOM   2107 C CZ  . ARG A 1 353 ? -1.084  2.259   -18.739 1.00 190.88 ? 279  ARG A CZ  1 
ATOM   2108 N NH1 . ARG A 1 353 ? -1.029  2.095   -17.427 1.00 190.22 ? 279  ARG A NH1 1 
ATOM   2109 N NH2 . ARG A 1 353 ? -0.563  1.328   -19.533 1.00 184.97 ? 279  ARG A NH2 1 
ATOM   2110 N N   . THR A 1 354 ? -6.828  4.857   -18.123 1.00 119.55 ? 280  THR A N   1 
ATOM   2111 C CA  . THR A 1 354 ? -7.551  5.606   -17.100 1.00 153.96 ? 280  THR A CA  1 
ATOM   2112 C C   . THR A 1 354 ? -7.897  4.708   -15.922 1.00 125.43 ? 280  THR A C   1 
ATOM   2113 O O   . THR A 1 354 ? -7.752  5.103   -14.756 1.00 122.23 ? 280  THR A O   1 
ATOM   2114 C CB  . THR A 1 354 ? -8.819  6.221   -17.691 1.00 171.03 ? 280  THR A CB  1 
ATOM   2115 O OG1 . THR A 1 354 ? -8.488  6.960   -18.873 1.00 182.64 ? 280  THR A OG1 1 
ATOM   2116 C CG2 . THR A 1 354 ? -9.479  7.151   -16.684 1.00 148.27 ? 280  THR A CG2 1 
ATOM   2117 N N   . LEU A 1 355 ? -8.358  3.493   -16.211 1.00 123.95 ? 281  LEU A N   1 
ATOM   2118 C CA  . LEU A 1 355 ? -8.637  2.541   -15.142 1.00 107.41 ? 281  LEU A CA  1 
ATOM   2119 C C   . LEU A 1 355 ? -7.409  2.343   -14.261 1.00 107.41 ? 281  LEU A C   1 
ATOM   2120 O O   . LEU A 1 355 ? -7.492  2.399   -13.027 1.00 129.61 ? 281  LEU A O   1 
ATOM   2121 C CB  . LEU A 1 355 ? -9.089  1.219   -15.753 1.00 116.90 ? 281  LEU A CB  1 
ATOM   2122 C CG  . LEU A 1 355 ? -9.584  0.135   -14.806 1.00 125.26 ? 281  LEU A CG  1 
ATOM   2123 C CD1 . LEU A 1 355 ? -10.828 0.601   -14.071 1.00 131.04 ? 281  LEU A CD1 1 
ATOM   2124 C CD2 . LEU A 1 355 ? -9.855  -1.140  -15.592 1.00 125.46 ? 281  LEU A CD2 1 
ATOM   2125 N N   . ALA A 1 356 ? -6.255  2.118   -14.887 1.00 107.41 ? 282  ALA A N   1 
ATOM   2126 C CA  . ALA A 1 356 ? -5.035  1.865   -14.129 1.00 107.56 ? 282  ALA A CA  1 
ATOM   2127 C C   . ALA A 1 356 ? -4.671  3.057   -13.259 1.00 107.41 ? 282  ALA A C   1 
ATOM   2128 O O   . ALA A 1 356 ? -4.284  2.896   -12.095 1.00 113.23 ? 282  ALA A O   1 
ATOM   2129 C CB  . ALA A 1 356 ? -3.886  1.543   -15.080 1.00 116.00 ? 282  ALA A CB  1 
ATOM   2130 N N   . VAL A 1 357 ? -4.775  4.263   -13.816 1.00 107.41 ? 283  VAL A N   1 
ATOM   2131 C CA  . VAL A 1 357 ? -4.445  5.459   -13.048 1.00 123.86 ? 283  VAL A CA  1 
ATOM   2132 C C   . VAL A 1 357 ? -5.351  5.566   -11.834 1.00 120.75 ? 283  VAL A C   1 
ATOM   2133 O O   . VAL A 1 357 ? -4.900  5.882   -10.724 1.00 113.81 ? 283  VAL A O   1 
ATOM   2134 C CB  . VAL A 1 357 ? -4.550  6.713   -13.935 1.00 117.07 ? 283  VAL A CB  1 
ATOM   2135 C CG1 . VAL A 1 357 ? -4.679  7.966   -13.078 1.00 133.12 ? 283  VAL A CG1 1 
ATOM   2136 C CG2 . VAL A 1 357 ? -3.344  6.813   -14.844 1.00 138.60 ? 283  VAL A CG2 1 
ATOM   2137 N N   . VAL A 1 358 ? -6.645  5.326   -12.028 1.00 107.41 ? 284  VAL A N   1 
ATOM   2138 C CA  . VAL A 1 358 ? -7.582  5.430   -10.918 1.00 124.31 ? 284  VAL A CA  1 
ATOM   2139 C C   . VAL A 1 358 ? -7.226  4.426   -9.833  1.00 112.84 ? 284  VAL A C   1 
ATOM   2140 O O   . VAL A 1 358 ? -7.221  4.748   -8.638  1.00 122.89 ? 284  VAL A O   1 
ATOM   2141 C CB  . VAL A 1 358 ? -9.022  5.233   -11.420 1.00 127.35 ? 284  VAL A CB  1 
ATOM   2142 C CG1 . VAL A 1 358 ? -9.986  5.197   -10.247 1.00 151.66 ? 284  VAL A CG1 1 
ATOM   2143 C CG2 . VAL A 1 358 ? -9.393  6.341   -12.395 1.00 135.58 ? 284  VAL A CG2 1 
ATOM   2144 N N   . LEU A 1 359 ? -6.935  3.189   -10.232 1.00 107.41 ? 285  LEU A N   1 
ATOM   2145 C CA  . LEU A 1 359 ? -6.567  2.176   -9.251  1.00 108.10 ? 285  LEU A CA  1 
ATOM   2146 C C   . LEU A 1 359 ? -5.339  2.611   -8.464  1.00 111.96 ? 285  LEU A C   1 
ATOM   2147 O O   . LEU A 1 359 ? -5.298  2.498   -7.232  1.00 145.82 ? 285  LEU A O   1 
ATOM   2148 C CB  . LEU A 1 359 ? -6.310  0.845   -9.953  1.00 137.78 ? 285  LEU A CB  1 
ATOM   2149 C CG  . LEU A 1 359 ? -7.503  0.260   -10.706 1.00 149.96 ? 285  LEU A CG  1 
ATOM   2150 C CD1 . LEU A 1 359 ? -7.075  -0.932  -11.547 1.00 134.21 ? 285  LEU A CD1 1 
ATOM   2151 C CD2 . LEU A 1 359 ? -8.594  -0.130  -9.729  1.00 152.06 ? 285  LEU A CD2 1 
ATOM   2152 N N   . GLY A 1 360 ? -4.324  3.114   -9.167  1.00 107.41 ? 286  GLY A N   1 
ATOM   2153 C CA  . GLY A 1 360 ? -3.114  3.539   -8.488  1.00 107.41 ? 286  GLY A CA  1 
ATOM   2154 C C   . GLY A 1 360 ? -3.371  4.658   -7.500  1.00 107.41 ? 286  GLY A C   1 
ATOM   2155 O O   . GLY A 1 360 ? -2.863  4.637   -6.377  1.00 118.01 ? 286  GLY A O   1 
ATOM   2156 N N   . THR A 1 361 ? -4.161  5.653   -7.904  1.00 107.41 ? 287  THR A N   1 
ATOM   2157 C CA  . THR A 1 361 ? -4.445  6.763   -7.002  1.00 126.26 ? 287  THR A CA  1 
ATOM   2158 C C   . THR A 1 361 ? -5.210  6.287   -5.775  1.00 107.41 ? 287  THR A C   1 
ATOM   2159 O O   . THR A 1 361 ? -4.899  6.687   -4.647  1.00 118.00 ? 287  THR A O   1 
ATOM   2160 C CB  . THR A 1 361 ? -5.235  7.852   -7.726  1.00 119.20 ? 287  THR A CB  1 
ATOM   2161 O OG1 . THR A 1 361 ? -6.481  7.317   -8.185  1.00 120.33 ? 287  THR A OG1 1 
ATOM   2162 C CG2 . THR A 1 361 ? -4.437  8.403   -8.906  1.00 118.12 ? 287  THR A CG2 1 
ATOM   2163 N N   . PHE A 1 362 ? -6.211  5.428   -5.972  1.00 107.41 ? 288  PHE A N   1 
ATOM   2164 C CA  . PHE A 1 362 ? -6.982  4.933   -4.838  1.00 107.41 ? 288  PHE A CA  1 
ATOM   2165 C C   . PHE A 1 362 ? -6.090  4.169   -3.870  1.00 114.25 ? 288  PHE A C   1 
ATOM   2166 O O   . PHE A 1 362 ? -6.146  4.378   -2.650  1.00 140.11 ? 288  PHE A O   1 
ATOM   2167 C CB  . PHE A 1 362 ? -8.123  4.048   -5.331  1.00 107.41 ? 288  PHE A CB  1 
ATOM   2168 C CG  . PHE A 1 362 ? -9.104  3.673   -4.260  1.00 123.22 ? 288  PHE A CG  1 
ATOM   2169 C CD1 . PHE A 1 362 ? -10.070 4.574   -3.843  1.00 130.87 ? 288  PHE A CD1 1 
ATOM   2170 C CD2 . PHE A 1 362 ? -9.067  2.419   -3.673  1.00 128.88 ? 288  PHE A CD2 1 
ATOM   2171 C CE1 . PHE A 1 362 ? -10.982 4.233   -2.859  1.00 158.28 ? 288  PHE A CE1 1 
ATOM   2172 C CE2 . PHE A 1 362 ? -9.976  2.071   -2.686  1.00 146.71 ? 288  PHE A CE2 1 
ATOM   2173 C CZ  . PHE A 1 362 ? -10.933 2.979   -2.278  1.00 156.39 ? 288  PHE A CZ  1 
ATOM   2174 N N   . GLY A 1 363 ? -5.251  3.278   -4.399  1.00 107.41 ? 289  GLY A N   1 
ATOM   2175 C CA  . GLY A 1 363 ? -4.349  2.538   -3.535  1.00 107.41 ? 289  GLY A CA  1 
ATOM   2176 C C   . GLY A 1 363 ? -3.408  3.451   -2.776  1.00 107.41 ? 289  GLY A C   1 
ATOM   2177 O O   . GLY A 1 363 ? -3.275  3.352   -1.557  1.00 165.73 ? 289  GLY A O   1 
ATOM   2178 N N   . ALA A 1 364 ? -2.772  4.384   -3.484  1.00 109.83 ? 290  ALA A N   1 
ATOM   2179 C CA  . ALA A 1 364 ? -1.821  5.274   -2.830  1.00 107.41 ? 290  ALA A CA  1 
ATOM   2180 C C   . ALA A 1 364 ? -2.495  6.093   -1.740  1.00 112.91 ? 290  ALA A C   1 
ATOM   2181 O O   . ALA A 1 364 ? -1.912  6.326   -0.676  1.00 131.13 ? 290  ALA A O   1 
ATOM   2182 C CB  . ALA A 1 364 ? -1.174  6.195   -3.862  1.00 115.55 ? 290  ALA A CB  1 
ATOM   2183 N N   . CYS A 1 365 ? -3.723  6.545   -1.987  1.00 114.14 ? 291  CYS A N   1 
ATOM   2184 C CA  . CYS A 1 365 ? -4.391  7.402   -1.017  1.00 127.80 ? 291  CYS A CA  1 
ATOM   2185 C C   . CYS A 1 365 ? -4.863  6.617   0.200   1.00 137.20 ? 291  CYS A C   1 
ATOM   2186 O O   . CYS A 1 365 ? -4.769  7.108   1.332   1.00 179.76 ? 291  CYS A O   1 
ATOM   2187 C CB  . CYS A 1 365 ? -5.563  8.114   -1.685  1.00 131.69 ? 291  CYS A CB  1 
ATOM   2188 S SG  . CYS A 1 365 ? -5.068  9.360   -2.900  1.00 130.01 ? 291  CYS A SG  1 
ATOM   2189 N N   . TRP A 1 366 ? -5.368  5.400   -0.001  1.00 107.41 ? 292  TRP A N   1 
ATOM   2190 C CA  . TRP A 1 366 ? -6.013  4.702   1.104   1.00 141.40 ? 292  TRP A CA  1 
ATOM   2191 C C   . TRP A 1 366 ? -5.083  3.754   1.847   1.00 124.36 ? 292  TRP A C   1 
ATOM   2192 O O   . TRP A 1 366 ? -5.201  3.616   3.069   1.00 182.09 ? 292  TRP A O   1 
ATOM   2193 C CB  . TRP A 1 366 ? -7.234  3.936   0.594   1.00 145.33 ? 292  TRP A CB  1 
ATOM   2194 C CG  . TRP A 1 366 ? -8.462  4.782   0.558   1.00 149.77 ? 292  TRP A CG  1 
ATOM   2195 C CD1 . TRP A 1 366 ? -9.062  5.309   -0.544  1.00 146.04 ? 292  TRP A CD1 1 
ATOM   2196 C CD2 . TRP A 1 366 ? -9.235  5.215   1.683   1.00 158.33 ? 292  TRP A CD2 1 
ATOM   2197 N NE1 . TRP A 1 366 ? -10.170 6.037   -0.179  1.00 155.94 ? 292  TRP A NE1 1 
ATOM   2198 C CE2 . TRP A 1 366 ? -10.296 5.996   1.185   1.00 163.56 ? 292  TRP A CE2 1 
ATOM   2199 C CE3 . TRP A 1 366 ? -9.133  5.017   3.063   1.00 170.15 ? 292  TRP A CE3 1 
ATOM   2200 C CZ2 . TRP A 1 366 ? -11.249 6.578   2.017   1.00 155.49 ? 292  TRP A CZ2 1 
ATOM   2201 C CZ3 . TRP A 1 366 ? -10.081 5.594   3.887   1.00 147.55 ? 292  TRP A CZ3 1 
ATOM   2202 C CH2 . TRP A 1 366 ? -11.124 6.364   3.362   1.00 144.80 ? 292  TRP A CH2 1 
ATOM   2203 N N   . LEU A 1 367 ? -4.160  3.097   1.153   1.00 107.41 ? 293  LEU A N   1 
ATOM   2204 C CA  . LEU A 1 367 ? -3.260  2.163   1.818   1.00 107.41 ? 293  LEU A CA  1 
ATOM   2205 C C   . LEU A 1 367 ? -2.508  2.779   2.986   1.00 107.41 ? 293  LEU A C   1 
ATOM   2206 O O   . LEU A 1 367 ? -2.306  2.075   3.987   1.00 118.28 ? 293  LEU A O   1 
ATOM   2207 C CB  . LEU A 1 367 ? -2.276  1.585   0.794   1.00 107.41 ? 293  LEU A CB  1 
ATOM   2208 C CG  . LEU A 1 367 ? -2.881  0.543   -0.146  1.00 107.41 ? 293  LEU A CG  1 
ATOM   2209 C CD1 . LEU A 1 367 ? -1.931  0.257   -1.283  1.00 128.08 ? 293  LEU A CD1 1 
ATOM   2210 C CD2 . LEU A 1 367 ? -3.198  -0.736  0.595   1.00 122.57 ? 293  LEU A CD2 1 
ATOM   2211 N N   . PRO A 1 368 ? -2.048  4.029   2.933   1.00 107.41 ? 294  PRO A N   1 
ATOM   2212 C CA  . PRO A 1 368 ? -1.449  4.618   4.143   1.00 119.49 ? 294  PRO A CA  1 
ATOM   2213 C C   . PRO A 1 368 ? -2.358  4.488   5.354   1.00 133.90 ? 294  PRO A C   1 
ATOM   2214 O O   . PRO A 1 368 ? -1.953  3.935   6.385   1.00 114.54 ? 294  PRO A O   1 
ATOM   2215 C CB  . PRO A 1 368 ? -1.216  6.078   3.735   1.00 138.68 ? 294  PRO A CB  1 
ATOM   2216 C CG  . PRO A 1 368 ? -1.127  6.047   2.254   1.00 135.11 ? 294  PRO A CG  1 
ATOM   2217 C CD  . PRO A 1 368 ? -2.077  4.983   1.814   1.00 107.41 ? 294  PRO A CD  1 
ATOM   2218 N N   . PHE A 1 369 ? -3.596  4.970   5.247   1.00 127.50 ? 295  PHE A N   1 
ATOM   2219 C CA  . PHE A 1 369 ? -4.543  4.784   6.337   1.00 107.41 ? 295  PHE A CA  1 
ATOM   2220 C C   . PHE A 1 369 ? -4.854  3.312   6.549   1.00 107.41 ? 295  PHE A C   1 
ATOM   2221 O O   . PHE A 1 369 ? -4.980  2.855   7.690   1.00 132.74 ? 295  PHE A O   1 
ATOM   2222 C CB  . PHE A 1 369 ? -5.833  5.550   6.064   1.00 136.60 ? 295  PHE A CB  1 
ATOM   2223 C CG  . PHE A 1 369 ? -6.882  5.329   7.109   1.00 138.74 ? 295  PHE A CG  1 
ATOM   2224 C CD1 . PHE A 1 369 ? -7.745  4.250   7.027   1.00 143.10 ? 295  PHE A CD1 1 
ATOM   2225 C CD2 . PHE A 1 369 ? -6.990  6.185   8.188   1.00 123.26 ? 295  PHE A CD2 1 
ATOM   2226 C CE1 . PHE A 1 369 ? -8.696  4.035   7.997   1.00 132.15 ? 295  PHE A CE1 1 
ATOM   2227 C CE2 . PHE A 1 369 ? -7.945  5.977   9.155   1.00 148.54 ? 295  PHE A CE2 1 
ATOM   2228 C CZ  . PHE A 1 369 ? -8.800  4.901   9.059   1.00 139.66 ? 295  PHE A CZ  1 
ATOM   2229 N N   . ALA A 1 370 ? -5.018  2.557   5.463   1.00 112.04 ? 296  ALA A N   1 
ATOM   2230 C CA  . ALA A 1 370 ? -5.388  1.155   5.612   1.00 119.32 ? 296  ALA A CA  1 
ATOM   2231 C C   . ALA A 1 370 ? -4.378  0.412   6.472   1.00 116.74 ? 296  ALA A C   1 
ATOM   2232 O O   . ALA A 1 370 ? -4.731  -0.554  7.157   1.00 116.72 ? 296  ALA A O   1 
ATOM   2233 C CB  . ALA A 1 370 ? -5.514  0.493   4.241   1.00 116.41 ? 296  ALA A CB  1 
ATOM   2234 N N   . ILE A 1 371 ? -3.127  0.852   6.455   1.00 120.26 ? 297  ILE A N   1 
ATOM   2235 C CA  . ILE A 1 371 ? -2.094  0.261   7.292   1.00 120.75 ? 297  ILE A CA  1 
ATOM   2236 C C   . ILE A 1 371 ? -2.089  0.888   8.674   1.00 132.36 ? 297  ILE A C   1 
ATOM   2237 O O   . ILE A 1 371 ? -2.022  0.187   9.686   1.00 125.25 ? 297  ILE A O   1 
ATOM   2238 C CB  . ILE A 1 371 ? -0.720  0.413   6.608   1.00 132.24 ? 297  ILE A CB  1 
ATOM   2239 C CG1 . ILE A 1 371 ? -0.699  -0.340  5.278   1.00 107.94 ? 297  ILE A CG1 1 
ATOM   2240 C CG2 . ILE A 1 371 ? 0.383   -0.072  7.535   1.00 122.25 ? 297  ILE A CG2 1 
ATOM   2241 C CD1 . ILE A 1 371 ? 0.489   -0.001  4.408   1.00 118.49 ? 297  ILE A CD1 1 
ATOM   2242 N N   . TYR A 1 372 ? -2.170  2.218   8.730   1.00 126.46 ? 298  TYR A N   1 
ATOM   2243 C CA  . TYR A 1 372 ? -2.041  2.911   10.005  1.00 131.68 ? 298  TYR A CA  1 
ATOM   2244 C C   . TYR A 1 372 ? -3.149  2.518   10.972  1.00 133.15 ? 298  TYR A C   1 
ATOM   2245 O O   . TYR A 1 372 ? -2.891  2.287   12.158  1.00 154.60 ? 298  TYR A O   1 
ATOM   2246 C CB  . TYR A 1 372 ? -2.048  4.420   9.779   1.00 128.97 ? 298  TYR A CB  1 
ATOM   2247 C CG  . TYR A 1 372 ? -1.837  5.207   11.047  1.00 151.44 ? 298  TYR A CG  1 
ATOM   2248 C CD1 . TYR A 1 372 ? -0.596  5.234   11.669  1.00 153.01 ? 298  TYR A CD1 1 
ATOM   2249 C CD2 . TYR A 1 372 ? -2.876  5.921   11.628  1.00 147.72 ? 298  TYR A CD2 1 
ATOM   2250 C CE1 . TYR A 1 372 ? -0.393  5.951   12.833  1.00 148.04 ? 298  TYR A CE1 1 
ATOM   2251 C CE2 . TYR A 1 372 ? -2.682  6.643   12.793  1.00 184.11 ? 298  TYR A CE2 1 
ATOM   2252 C CZ  . TYR A 1 372 ? -1.438  6.655   13.391  1.00 152.82 ? 298  TYR A CZ  1 
ATOM   2253 O OH  . TYR A 1 372 ? -1.241  7.372   14.550  1.00 164.84 ? 298  TYR A OH  1 
ATOM   2254 N N   . CYS A 1 373 ? -4.387  2.420   10.486  1.00 117.31 ? 299  CYS A N   1 
ATOM   2255 C CA  . CYS A 1 373 ? -5.508  2.149   11.377  1.00 131.57 ? 299  CYS A CA  1 
ATOM   2256 C C   . CYS A 1 373 ? -5.329  0.840   12.129  1.00 139.44 ? 299  CYS A C   1 
ATOM   2257 O O   . CYS A 1 373 ? -5.956  0.646   13.177  1.00 128.49 ? 299  CYS A O   1 
ATOM   2258 C CB  . CYS A 1 373 ? -6.816  2.118   10.585  1.00 141.12 ? 299  CYS A CB  1 
ATOM   2259 S SG  . CYS A 1 373 ? -7.031  0.644   9.573   1.00 130.42 ? 299  CYS A SG  1 
ATOM   2260 N N   . VAL A 1 374 ? -4.492  -0.057  11.619  1.00 125.94 ? 300  VAL A N   1 
ATOM   2261 C CA  . VAL A 1 374 ? -4.186  -1.319  12.279  1.00 151.03 ? 300  VAL A CA  1 
ATOM   2262 C C   . VAL A 1 374 ? -2.884  -1.237  13.060  1.00 131.02 ? 300  VAL A C   1 
ATOM   2263 O O   . VAL A 1 374 ? -2.815  -1.659  14.213  1.00 132.74 ? 300  VAL A O   1 
ATOM   2264 C CB  . VAL A 1 374 ? -4.140  -2.459  11.238  1.00 134.35 ? 300  VAL A CB  1 
ATOM   2265 C CG1 . VAL A 1 374 ? -3.649  -3.738  11.886  1.00 123.31 ? 300  VAL A CG1 1 
ATOM   2266 C CG2 . VAL A 1 374 ? -5.510  -2.648  10.610  1.00 139.55 ? 300  VAL A CG2 1 
ATOM   2267 N N   . VAL A 1 375 ? -1.831  -0.697  12.437  1.00 125.06 ? 301  VAL A N   1 
ATOM   2268 C CA  . VAL A 1 375 ? -0.548  -0.522  13.117  1.00 133.34 ? 301  VAL A CA  1 
ATOM   2269 C C   . VAL A 1 375 ? -0.531  0.716   13.996  1.00 145.99 ? 301  VAL A C   1 
ATOM   2270 O O   . VAL A 1 375 ? 0.475   0.973   14.671  1.00 147.70 ? 301  VAL A O   1 
ATOM   2271 C CB  . VAL A 1 375 ? 0.581   -0.490  12.065  1.00 138.46 ? 301  VAL A CB  1 
ATOM   2272 C CG1 . VAL A 1 375 ? 1.928   -0.138  12.695  1.00 137.38 ? 301  VAL A CG1 1 
ATOM   2273 C CG2 . VAL A 1 375 ? 0.668   -1.837  11.355  1.00 121.12 ? 301  VAL A CG2 1 
ATOM   2274 N N   . GLY A 1 376 ? -1.621  1.478   14.035  1.00 164.71 ? 302  GLY A N   1 
ATOM   2275 C CA  . GLY A 1 376 ? -1.685  2.614   14.935  1.00 154.46 ? 302  GLY A CA  1 
ATOM   2276 C C   . GLY A 1 376 ? -1.501  2.188   16.379  1.00 159.67 ? 302  GLY A C   1 
ATOM   2277 O O   . GLY A 1 376 ? -1.813  1.059   16.762  1.00 163.85 ? 302  GLY A O   1 
ATOM   2278 N N   . SER A 1 377 ? -0.991  3.116   17.192  1.00 163.56 ? 303  SER A N   1 
ATOM   2279 C CA  . SER A 1 377 ? -0.491  2.781   18.518  1.00 171.87 ? 303  SER A CA  1 
ATOM   2280 C C   . SER A 1 377 ? -1.357  3.277   19.667  1.00 172.48 ? 303  SER A C   1 
ATOM   2281 O O   . SER A 1 377 ? -1.085  2.907   20.815  1.00 180.30 ? 303  SER A O   1 
ATOM   2282 C CB  . SER A 1 377 ? 0.928   3.342   18.701  1.00 162.56 ? 303  SER A CB  1 
ATOM   2283 O OG  . SER A 1 377 ? 1.773   2.947   17.636  1.00 190.18 ? 303  SER A OG  1 
ATOM   2284 N N   . HIS A 1 378 ? -2.365  4.111   19.411  1.00 174.71 ? 304  HIS A N   1 
ATOM   2285 C CA  . HIS A 1 378 ? -3.257  4.648   20.437  1.00 184.21 ? 304  HIS A CA  1 
ATOM   2286 C C   . HIS A 1 378 ? -2.544  5.651   21.341  1.00 178.39 ? 304  HIS A C   1 
ATOM   2287 O O   . HIS A 1 378 ? -3.189  6.270   22.194  1.00 186.02 ? 304  HIS A O   1 
ATOM   2288 C CB  . HIS A 1 378 ? -3.873  3.520   21.282  1.00 205.53 ? 304  HIS A CB  1 
ATOM   2289 C CG  . HIS A 1 378 ? -4.782  3.988   22.376  1.00 205.42 ? 304  HIS A CG  1 
ATOM   2290 N ND1 . HIS A 1 378 ? -4.311  4.449   23.587  1.00 175.72 ? 304  HIS A ND1 1 
ATOM   2291 C CD2 . HIS A 1 378 ? -6.133  4.038   22.455  1.00 190.82 ? 304  HIS A CD2 1 
ATOM   2292 C CE1 . HIS A 1 378 ? -5.332  4.778   24.358  1.00 177.11 ? 304  HIS A CE1 1 
ATOM   2293 N NE2 . HIS A 1 378 ? -6.449  4.538   23.696  1.00 173.62 ? 304  HIS A NE2 1 
ATOM   2294 N N   . GLU A 1 379 ? -1.239  5.848   21.166  1.00 175.10 ? 305  GLU A N   1 
ATOM   2295 C CA  . GLU A 1 379 ? -0.483  6.854   21.893  1.00 167.14 ? 305  GLU A CA  1 
ATOM   2296 C C   . GLU A 1 379 ? 0.332   7.730   20.953  1.00 168.36 ? 305  GLU A C   1 
ATOM   2297 O O   . GLU A 1 379 ? 1.079   8.594   21.428  1.00 201.95 ? 305  GLU A O   1 
ATOM   2298 C CB  . GLU A 1 379 ? 0.449   6.186   22.916  1.00 148.27 ? 305  GLU A CB  1 
ATOM   2299 C CG  . GLU A 1 379 ? -0.187  4.993   23.621  1.00 184.38 ? 305  GLU A CG  1 
ATOM   2300 C CD  . GLU A 1 379 ? 0.582   4.545   24.852  1.00 194.33 ? 305  GLU A CD  1 
ATOM   2301 O OE1 . GLU A 1 379 ? 1.222   5.397   25.504  1.00 215.93 ? 305  GLU A OE1 1 
ATOM   2302 O OE2 . GLU A 1 379 ? 0.544   3.337   25.169  1.00 206.52 ? 305  GLU A OE2 1 
ATOM   2303 N N   . ASP A 1 380 ? 0.206   7.532   19.643  1.00 177.90 ? 306  ASP A N   1 
ATOM   2304 C CA  . ASP A 1 380 ? 0.959   8.279   18.648  1.00 160.90 ? 306  ASP A CA  1 
ATOM   2305 C C   . ASP A 1 380 ? 0.397   9.685   18.494  1.00 181.44 ? 306  ASP A C   1 
ATOM   2306 O O   . ASP A 1 380 ? -0.705  9.988   18.956  1.00 197.73 ? 306  ASP A O   1 
ATOM   2307 C CB  . ASP A 1 380 ? 0.919   7.550   17.306  1.00 155.13 ? 306  ASP A CB  1 
ATOM   2308 C CG  . ASP A 1 380 ? 1.837   6.346   17.262  1.00 158.59 ? 306  ASP A CG  1 
ATOM   2309 O OD1 . ASP A 1 380 ? 2.928   6.405   17.864  1.00 174.94 ? 306  ASP A OD1 1 
ATOM   2310 O OD2 . ASP A 1 380 ? 1.468   5.340   16.620  1.00 156.84 ? 306  ASP A OD2 1 
ATOM   2311 N N   . PRO A 1 381 ? 1.144   10.578  17.845  1.00 163.98 ? 307  PRO A N   1 
ATOM   2312 C CA  . PRO A 1 381 ? 0.625   11.926  17.591  1.00 167.02 ? 307  PRO A CA  1 
ATOM   2313 C C   . PRO A 1 381 ? -0.580  11.899  16.664  1.00 173.67 ? 307  PRO A C   1 
ATOM   2314 O O   . PRO A 1 381 ? -0.757  10.982  15.858  1.00 165.18 ? 307  PRO A O   1 
ATOM   2315 C CB  . PRO A 1 381 ? 1.811   12.652  16.943  1.00 158.40 ? 307  PRO A CB  1 
ATOM   2316 C CG  . PRO A 1 381 ? 3.011   11.854  17.317  1.00 159.57 ? 307  PRO A CG  1 
ATOM   2317 C CD  . PRO A 1 381 ? 2.544   10.437  17.411  1.00 156.74 ? 307  PRO A CD  1 
ATOM   2318 N N   . ALA A 1 382 ? -1.418  12.929  16.793  1.00 156.33 ? 308  ALA A N   1 
ATOM   2319 C CA  . ALA A 1 382 ? -2.606  13.025  15.955  1.00 166.48 ? 308  ALA A CA  1 
ATOM   2320 C C   . ALA A 1 382 ? -2.244  13.189  14.488  1.00 173.04 ? 308  ALA A C   1 
ATOM   2321 O O   . ALA A 1 382 ? -3.009  12.774  13.610  1.00 174.69 ? 308  ALA A O   1 
ATOM   2322 C CB  . ALA A 1 382 ? -3.473  14.199  16.408  1.00 171.50 ? 308  ALA A CB  1 
ATOM   2323 N N   . VAL A 1 383 ? -1.082  13.780  14.203  1.00 175.87 ? 309  VAL A N   1 
ATOM   2324 C CA  . VAL A 1 383 ? -0.755  14.147  12.829  1.00 172.29 ? 309  VAL A CA  1 
ATOM   2325 C C   . VAL A 1 383 ? -0.798  12.927  11.920  1.00 165.06 ? 309  VAL A C   1 
ATOM   2326 O O   . VAL A 1 383 ? -1.296  13.002  10.794  1.00 156.82 ? 309  VAL A O   1 
ATOM   2327 C CB  . VAL A 1 383 ? 0.612   14.855  12.769  1.00 178.86 ? 309  VAL A CB  1 
ATOM   2328 C CG1 . VAL A 1 383 ? 1.717   13.935  13.243  1.00 180.07 ? 309  VAL A CG1 1 
ATOM   2329 C CG2 . VAL A 1 383 ? 0.899   15.352  11.350  1.00 205.50 ? 309  VAL A CG2 1 
ATOM   2330 N N   . TYR A 1 384 ? -0.290  11.788  12.391  1.00 154.21 ? 310  TYR A N   1 
ATOM   2331 C CA  . TYR A 1 384 ? -0.282  10.584  11.565  1.00 135.74 ? 310  TYR A CA  1 
ATOM   2332 C C   . TYR A 1 384 ? -1.674  10.294  11.013  1.00 139.93 ? 310  TYR A C   1 
ATOM   2333 O O   . TYR A 1 384 ? -1.844  9.982   9.824   1.00 154.08 ? 310  TYR A O   1 
ATOM   2334 C CB  . TYR A 1 384 ? 0.222   9.397   12.387  1.00 171.74 ? 310  TYR A CB  1 
ATOM   2335 C CG  . TYR A 1 384 ? 1.640   9.534   12.909  1.00 160.79 ? 310  TYR A CG  1 
ATOM   2336 C CD1 . TYR A 1 384 ? 2.431   10.625  12.570  1.00 173.55 ? 310  TYR A CD1 1 
ATOM   2337 C CD2 . TYR A 1 384 ? 2.191   8.562   13.734  1.00 175.22 ? 310  TYR A CD2 1 
ATOM   2338 C CE1 . TYR A 1 384 ? 3.724   10.747  13.044  1.00 159.48 ? 310  TYR A CE1 1 
ATOM   2339 C CE2 . TYR A 1 384 ? 3.485   8.675   14.211  1.00 159.94 ? 310  TYR A CE2 1 
ATOM   2340 C CZ  . TYR A 1 384 ? 4.246   9.770   13.863  1.00 155.78 ? 310  TYR A CZ  1 
ATOM   2341 O OH  . TYR A 1 384 ? 5.534   9.889   14.334  1.00 178.54 ? 310  TYR A OH  1 
ATOM   2342 N N   . THR A 1 385 ? -2.684  10.393  11.877  1.00 148.45 ? 311  THR A N   1 
ATOM   2343 C CA  . THR A 1 385 ? -4.057  10.166  11.450  1.00 120.02 ? 311  THR A CA  1 
ATOM   2344 C C   . THR A 1 385 ? -4.396  11.027  10.244  1.00 140.58 ? 311  THR A C   1 
ATOM   2345 O O   . THR A 1 385 ? -4.887  10.530  9.225   1.00 161.36 ? 311  THR A O   1 
ATOM   2346 C CB  . THR A 1 385 ? -5.008  10.475  12.603  1.00 124.48 ? 311  THR A CB  1 
ATOM   2347 O OG1 . THR A 1 385 ? -4.617  9.729   13.761  1.00 154.14 ? 311  THR A OG1 1 
ATOM   2348 C CG2 . THR A 1 385 ? -6.432  10.126  12.220  1.00 155.26 ? 311  THR A CG2 1 
ATOM   2349 N N   . TYR A 1 386 ? -4.138  12.331  10.349  1.00 143.23 ? 312  TYR A N   1 
ATOM   2350 C CA  . TYR A 1 386 ? -4.362  13.220  9.219   1.00 113.82 ? 312  TYR A CA  1 
ATOM   2351 C C   . TYR A 1 386 ? -3.551  12.762  8.016   1.00 116.56 ? 312  TYR A C   1 
ATOM   2352 O O   . TYR A 1 386 ? -4.105  12.398  6.985   1.00 115.19 ? 312  TYR A O   1 
ATOM   2353 C CB  . TYR A 1 386 ? -4.008  14.656  9.604   1.00 145.01 ? 312  TYR A CB  1 
ATOM   2354 N N   . ALA A 1 387 ? -2.230  12.699  8.155   1.00 123.46 ? 313  ALA A N   1 
ATOM   2355 C CA  . ALA A 1 387 ? -1.384  12.351  7.020   1.00 129.34 ? 313  ALA A CA  1 
ATOM   2356 C C   . ALA A 1 387 ? -1.879  11.116  6.279   1.00 135.03 ? 313  ALA A C   1 
ATOM   2357 O O   . ALA A 1 387 ? -1.570  10.954  5.094   1.00 151.85 ? 313  ALA A O   1 
ATOM   2358 C CB  . ALA A 1 387 ? 0.054   12.133  7.492   1.00 123.21 ? 313  ALA A CB  1 
ATOM   2359 N N   . THR A 1 388 ? -2.631  10.240  6.946   1.00 131.09 ? 314  THR A N   1 
ATOM   2360 C CA  . THR A 1 388 ? -3.206  9.092   6.252   1.00 121.73 ? 314  THR A CA  1 
ATOM   2361 C C   . THR A 1 388 ? -4.608  9.358   5.716   1.00 131.87 ? 314  THR A C   1 
ATOM   2362 O O   . THR A 1 388 ? -4.971  8.818   4.665   1.00 157.85 ? 314  THR A O   1 
ATOM   2363 C CB  . THR A 1 388 ? -3.248  7.876   7.179   1.00 143.93 ? 314  THR A CB  1 
ATOM   2364 O OG1 . THR A 1 388 ? -4.104  8.151   8.295   1.00 132.05 ? 314  THR A OG1 1 
ATOM   2365 C CG2 . THR A 1 388 ? -1.852  7.530   7.674   1.00 116.03 ? 314  THR A CG2 1 
ATOM   2366 N N   . LEU A 1 389 ? -5.407  10.166  6.416   1.00 107.41 ? 315  LEU A N   1 
ATOM   2367 C CA  . LEU A 1 389 ? -6.749  10.494  5.941   1.00 107.41 ? 315  LEU A CA  1 
ATOM   2368 C C   . LEU A 1 389 ? -6.719  11.540  4.832   1.00 131.24 ? 315  LEU A C   1 
ATOM   2369 O O   . LEU A 1 389 ? -7.538  11.499  3.910   1.00 123.53 ? 315  LEU A O   1 
ATOM   2370 C CB  . LEU A 1 389 ? -7.601  10.993  7.104   1.00 107.41 ? 315  LEU A CB  1 
ATOM   2371 C CG  . LEU A 1 389 ? -8.044  9.938   8.114   1.00 120.77 ? 315  LEU A CG  1 
ATOM   2372 C CD1 . LEU A 1 389 ? -8.635  10.613  9.336   1.00 146.92 ? 315  LEU A CD1 1 
ATOM   2373 C CD2 . LEU A 1 389 ? -9.052  8.984   7.497   1.00 139.54 ? 315  LEU A CD2 1 
ATOM   2374 N N   . LEU A 1 390 ? -5.792  12.484  4.922   1.00 120.39 ? 316  LEU A N   1 
ATOM   2375 C CA  . LEU A 1 390 ? -5.657  13.528  3.913   1.00 115.10 ? 316  LEU A CA  1 
ATOM   2376 C C   . LEU A 1 390 ? -5.475  12.940  2.526   1.00 125.65 ? 316  LEU A C   1 
ATOM   2377 O O   . LEU A 1 390 ? -6.217  13.336  1.612   1.00 125.25 ? 316  LEU A O   1 
ATOM   2378 C CB  . LEU A 1 390 ? -4.496  14.453  4.296   1.00 147.81 ? 316  LEU A CB  1 
ATOM   2379 C CG  . LEU A 1 390 ? -4.246  15.644  3.372   1.00 138.64 ? 316  LEU A CG  1 
ATOM   2380 C CD1 . LEU A 1 390 ? -5.328  16.698  3.568   1.00 141.19 ? 316  LEU A CD1 1 
ATOM   2381 C CD2 . LEU A 1 390 ? -2.859  16.230  3.605   1.00 125.09 ? 316  LEU A CD2 1 
ATOM   2382 N N   . PRO A 1 391 ? -4.558  12.000  2.292   1.00 126.39 ? 317  PRO A N   1 
ATOM   2383 C CA  . PRO A 1 391 ? -4.584  11.303  0.998   1.00 107.41 ? 317  PRO A CA  1 
ATOM   2384 C C   . PRO A 1 391 ? -5.905  10.604  0.761   1.00 107.41 ? 317  PRO A C   1 
ATOM   2385 O O   . PRO A 1 391 ? -6.520  10.780  -0.294  1.00 141.96 ? 317  PRO A O   1 
ATOM   2386 C CB  . PRO A 1 391 ? -3.420  10.308  1.106   1.00 107.41 ? 317  PRO A CB  1 
ATOM   2387 C CG  . PRO A 1 391 ? -2.565  10.816  2.198   1.00 138.49 ? 317  PRO A CG  1 
ATOM   2388 C CD  . PRO A 1 391 ? -3.479  11.501  3.158   1.00 126.48 ? 317  PRO A CD  1 
ATOM   2389 N N   . ALA A 1 392 ? -6.366  9.817   1.732   1.00 107.41 ? 318  ALA A N   1 
ATOM   2390 C CA  . ALA A 1 392 ? -7.597  9.059   1.546   1.00 126.23 ? 318  ALA A CA  1 
ATOM   2391 C C   . ALA A 1 392 ? -8.780  9.979   1.284   1.00 122.98 ? 318  ALA A C   1 
ATOM   2392 O O   . ALA A 1 392 ? -9.614  9.698   0.417   1.00 134.15 ? 318  ALA A O   1 
ATOM   2393 C CB  . ALA A 1 392 ? -7.861  8.188   2.773   1.00 147.13 ? 318  ALA A CB  1 
ATOM   2394 N N   . THR A 1 393 ? -8.879  11.079  2.029   1.00 136.97 ? 319  THR A N   1 
ATOM   2395 C CA  . THR A 1 393 ? -10.010 11.980  1.844   1.00 144.87 ? 319  THR A CA  1 
ATOM   2396 C C   . THR A 1 393 ? -9.916  12.712  0.509   1.00 128.37 ? 319  THR A C   1 
ATOM   2397 O O   . THR A 1 393 ? -10.890 12.763  -0.250  1.00 109.08 ? 319  THR A O   1 
ATOM   2398 C CB  . THR A 1 393 ? -10.098 12.967  3.012   1.00 137.47 ? 319  THR A CB  1 
ATOM   2399 O OG1 . THR A 1 393 ? -11.320 13.710  2.921   1.00 161.91 ? 319  THR A OG1 1 
ATOM   2400 C CG2 . THR A 1 393 ? -8.932  13.933  3.007   1.00 135.44 ? 319  THR A CG2 1 
ATOM   2401 N N   . LEU A 1 394 ? -8.743  13.261  0.185   1.00 124.86 ? 320  LEU A N   1 
ATOM   2402 C CA  . LEU A 1 394 ? -8.607  13.982  -1.073  1.00 118.61 ? 320  LEU A CA  1 
ATOM   2403 C C   . LEU A 1 394 ? -8.595  13.047  -2.272  1.00 129.34 ? 320  LEU A C   1 
ATOM   2404 O O   . LEU A 1 394 ? -8.601  13.523  -3.409  1.00 126.97 ? 320  LEU A O   1 
ATOM   2405 C CB  . LEU A 1 394 ? -7.344  14.844  -1.059  1.00 151.38 ? 320  LEU A CB  1 
ATOM   2406 C CG  . LEU A 1 394 ? -5.986  14.146  -1.133  1.00 157.02 ? 320  LEU A CG  1 
ATOM   2407 C CD1 . LEU A 1 394 ? -5.606  13.781  -2.559  1.00 140.73 ? 320  LEU A CD1 1 
ATOM   2408 C CD2 . LEU A 1 394 ? -4.921  15.034  -0.504  1.00 127.86 ? 320  LEU A CD2 1 
ATOM   2409 N N   . ASN A 1 395 ? -8.557  11.734  -2.049  1.00 133.70 ? 321  ASN A N   1 
ATOM   2410 C CA  . ASN A 1 395 ? -8.794  10.801  -3.143  1.00 110.18 ? 321  ASN A CA  1 
ATOM   2411 C C   . ASN A 1 395 ? -10.176 11.014  -3.738  1.00 114.87 ? 321  ASN A C   1 
ATOM   2412 O O   . ASN A 1 395 ? -10.345 10.999  -4.963  1.00 125.16 ? 321  ASN A O   1 
ATOM   2413 C CB  . ASN A 1 395 ? -8.648  9.368   -2.640  1.00 125.02 ? 321  ASN A CB  1 
ATOM   2414 C CG  . ASN A 1 395 ? -9.054  8.349   -3.671  1.00 125.94 ? 321  ASN A CG  1 
ATOM   2415 O OD1 . ASN A 1 395 ? -10.182 7.857   -3.660  1.00 123.71 ? 321  ASN A OD1 1 
ATOM   2416 N ND2 . ASN A 1 395 ? -8.136  8.022   -4.573  1.00 157.84 ? 321  ASN A ND2 1 
ATOM   2417 N N   . SER A 1 396 ? -11.181 11.202  -2.881  1.00 134.25 ? 322  SER A N   1 
ATOM   2418 C CA  . SER A 1 396 ? -12.518 11.518  -3.367  1.00 139.16 ? 322  SER A CA  1 
ATOM   2419 C C   . SER A 1 396 ? -12.527 12.824  -4.151  1.00 133.86 ? 322  SER A C   1 
ATOM   2420 O O   . SER A 1 396 ? -13.320 12.983  -5.085  1.00 128.21 ? 322  SER A O   1 
ATOM   2421 C CB  . SER A 1 396 ? -13.491 11.594  -2.188  1.00 145.52 ? 322  SER A CB  1 
ATOM   2422 O OG  . SER A 1 396 ? -13.510 10.379  -1.457  1.00 143.45 ? 322  SER A OG  1 
ATOM   2423 N N   . MET A 1 397 ? -11.655 13.767  -3.785  1.00 139.98 ? 323  MET A N   1 
ATOM   2424 C CA  . MET A 1 397 ? -11.567 15.030  -4.511  1.00 138.57 ? 323  MET A CA  1 
ATOM   2425 C C   . MET A 1 397 ? -10.908 14.839  -5.870  1.00 134.16 ? 323  MET A C   1 
ATOM   2426 O O   . MET A 1 397 ? -11.309 15.464  -6.858  1.00 147.74 ? 323  MET A O   1 
ATOM   2427 C CB  . MET A 1 397 ? -10.779 16.046  -3.684  1.00 149.18 ? 323  MET A CB  1 
ATOM   2428 C CG  . MET A 1 397 ? -10.794 17.460  -4.235  1.00 163.12 ? 323  MET A CG  1 
ATOM   2429 S SD  . MET A 1 397 ? -9.274  18.358  -3.859  1.00 228.57 ? 323  MET A SD  1 
ATOM   2430 C CE  . MET A 1 397 ? -8.182  17.711  -5.124  1.00 143.59 ? 323  MET A CE  1 
ATOM   2431 N N   . ILE A 1 398 ? -9.886  13.988  -5.932  1.00 137.43 ? 324  ILE A N   1 
ATOM   2432 C CA  . ILE A 1 398 ? -9.115  13.829  -7.157  1.00 124.86 ? 324  ILE A CA  1 
ATOM   2433 C C   . ILE A 1 398 ? -9.832  12.933  -8.154  1.00 120.94 ? 324  ILE A C   1 
ATOM   2434 O O   . ILE A 1 398 ? -9.626  13.064  -9.365  1.00 139.08 ? 324  ILE A O   1 
ATOM   2435 C CB  . ILE A 1 398 ? -7.714  13.288  -6.825  1.00 146.68 ? 324  ILE A CB  1 
ATOM   2436 C CG1 . ILE A 1 398 ? -6.839  14.422  -6.287  1.00 145.00 ? 324  ILE A CG1 1 
ATOM   2437 C CG2 . ILE A 1 398 ? -7.090  12.621  -8.047  1.00 116.42 ? 324  ILE A CG2 1 
ATOM   2438 C CD1 . ILE A 1 398 ? -5.469  13.987  -5.821  1.00 142.18 ? 324  ILE A CD1 1 
ATOM   2439 N N   . ASN A 1 399 ? -10.671 12.013  -7.681  1.00 127.39 ? 325  ASN A N   1 
ATOM   2440 C CA  . ASN A 1 399 ? -11.327 11.087  -8.601  1.00 148.18 ? 325  ASN A CA  1 
ATOM   2441 C C   . ASN A 1 399 ? -12.173 11.801  -9.646  1.00 146.38 ? 325  ASN A C   1 
ATOM   2442 O O   . ASN A 1 399 ? -12.042 11.478  -10.840 1.00 148.89 ? 325  ASN A O   1 
ATOM   2443 C CB  . ASN A 1 399 ? -12.158 10.078  -7.803  1.00 139.60 ? 325  ASN A CB  1 
ATOM   2444 C CG  . ASN A 1 399 ? -11.303 9.005   -7.158  1.00 149.05 ? 325  ASN A CG  1 
ATOM   2445 O OD1 . ASN A 1 399 ? -10.087 9.156   -7.030  1.00 154.92 ? 325  ASN A OD1 1 
ATOM   2446 N ND2 . ASN A 1 399 ? -11.934 7.913   -6.751  1.00 143.31 ? 325  ASN A ND2 1 
ATOM   2447 N N   . PRO A 1 400 ? -13.035 12.760  -9.296  1.00 141.32 ? 326  PRO A N   1 
ATOM   2448 C CA  . PRO A 1 400 ? -13.790 13.463  -10.347 1.00 145.61 ? 326  PRO A CA  1 
ATOM   2449 C C   . PRO A 1 400 ? -12.895 14.093  -11.402 1.00 137.62 ? 326  PRO A C   1 
ATOM   2450 O O   . PRO A 1 400 ? -13.249 14.111  -12.587 1.00 145.34 ? 326  PRO A O   1 
ATOM   2451 C CB  . PRO A 1 400 ? -14.580 14.519  -9.558  1.00 125.65 ? 326  PRO A CB  1 
ATOM   2452 C CG  . PRO A 1 400 ? -14.715 13.950  -8.191  1.00 136.29 ? 326  PRO A CG  1 
ATOM   2453 C CD  . PRO A 1 400 ? -13.464 13.158  -7.943  1.00 137.94 ? 326  PRO A CD  1 
ATOM   2454 N N   . ILE A 1 401 ? -11.729 14.600  -10.998 1.00 139.17 ? 327  ILE A N   1 
ATOM   2455 C CA  . ILE A 1 401 ? -10.849 15.312  -11.921 1.00 137.14 ? 327  ILE A CA  1 
ATOM   2456 C C   . ILE A 1 401 ? -10.345 14.383  -13.022 1.00 148.18 ? 327  ILE A C   1 
ATOM   2457 O O   . ILE A 1 401 ? -10.235 14.778  -14.195 1.00 177.58 ? 327  ILE A O   1 
ATOM   2458 C CB  . ILE A 1 401 ? -9.679  15.941  -11.137 1.00 146.89 ? 327  ILE A CB  1 
ATOM   2459 C CG1 . ILE A 1 401 ? -10.202 16.908  -10.067 1.00 151.43 ? 327  ILE A CG1 1 
ATOM   2460 C CG2 . ILE A 1 401 ? -8.722  16.649  -12.082 1.00 192.94 ? 327  ILE A CG2 1 
ATOM   2461 C CD1 . ILE A 1 401 ? -9.132  17.410  -9.110  1.00 151.56 ? 327  ILE A CD1 1 
ATOM   2462 N N   . ILE A 1 402 ? -9.997  13.149  -12.654 1.00 151.42 ? 328  ILE A N   1 
ATOM   2463 C CA  . ILE A 1 402 ? -9.295  12.249  -13.568 1.00 154.54 ? 328  ILE A CA  1 
ATOM   2464 C C   . ILE A 1 402 ? -10.113 12.027  -14.835 1.00 162.77 ? 328  ILE A C   1 
ATOM   2465 O O   . ILE A 1 402 ? -9.673  12.340  -15.952 1.00 167.76 ? 328  ILE A O   1 
ATOM   2466 C CB  . ILE A 1 402 ? -8.980  10.920  -12.857 1.00 165.51 ? 328  ILE A CB  1 
ATOM   2467 C CG1 . ILE A 1 402 ? -7.862  11.129  -11.828 1.00 159.93 ? 328  ILE A CG1 1 
ATOM   2468 C CG2 . ILE A 1 402 ? -8.616  9.840   -13.867 1.00 198.17 ? 328  ILE A CG2 1 
ATOM   2469 C CD1 . ILE A 1 402 ? -7.672  9.969   -10.869 1.00 138.06 ? 328  ILE A CD1 1 
ATOM   2470 N N   . TYR A 1 403 ? -11.320 11.483  -14.676 1.00 158.85 ? 329  TYR A N   1 
ATOM   2471 C CA  . TYR A 1 403 ? -12.153 11.184  -15.834 1.00 152.74 ? 329  TYR A CA  1 
ATOM   2472 C C   . TYR A 1 403 ? -12.335 12.410  -16.717 1.00 188.71 ? 329  TYR A C   1 
ATOM   2473 O O   . TYR A 1 403 ? -12.256 12.316  -17.948 1.00 204.08 ? 329  TYR A O   1 
ATOM   2474 C CB  . TYR A 1 403 ? -13.509 10.650  -15.378 1.00 145.54 ? 329  TYR A CB  1 
ATOM   2475 C CG  . TYR A 1 403 ? -13.516 9.166   -15.094 1.00 158.55 ? 329  TYR A CG  1 
ATOM   2476 C CD1 . TYR A 1 403 ? -12.977 8.661   -13.921 1.00 171.78 ? 329  TYR A CD1 1 
ATOM   2477 C CD2 . TYR A 1 403 ? -14.068 8.270   -16.002 1.00 175.58 ? 329  TYR A CD2 1 
ATOM   2478 C CE1 . TYR A 1 403 ? -12.984 7.300   -13.660 1.00 179.51 ? 329  TYR A CE1 1 
ATOM   2479 C CE2 . TYR A 1 403 ? -14.081 6.910   -15.751 1.00 177.64 ? 329  TYR A CE2 1 
ATOM   2480 C CZ  . TYR A 1 403 ? -13.539 6.429   -14.581 1.00 183.86 ? 329  TYR A CZ  1 
ATOM   2481 O OH  . TYR A 1 403 ? -13.556 5.072   -14.341 1.00 158.65 ? 329  TYR A OH  1 
ATOM   2482 N N   . ALA A 1 404 ? -12.573 13.573  -16.109 1.00 164.28 ? 330  ALA A N   1 
ATOM   2483 C CA  . ALA A 1 404 ? -12.758 14.787  -16.895 1.00 169.21 ? 330  ALA A CA  1 
ATOM   2484 C C   . ALA A 1 404 ? -11.546 15.056  -17.776 1.00 186.71 ? 330  ALA A C   1 
ATOM   2485 O O   . ALA A 1 404 ? -11.679 15.291  -18.983 1.00 197.52 ? 330  ALA A O   1 
ATOM   2486 C CB  . ALA A 1 404 ? -13.020 15.977  -15.972 1.00 174.39 ? 330  ALA A CB  1 
ATOM   2487 N N   . PHE A 1 405 ? -10.347 15.017  -17.190 1.00 179.11 ? 331  PHE A N   1 
ATOM   2488 C CA  . PHE A 1 405 ? -9.156  15.288  -17.989 1.00 197.37 ? 331  PHE A CA  1 
ATOM   2489 C C   . PHE A 1 405 ? -8.919  14.224  -19.046 1.00 188.09 ? 331  PHE A C   1 
ATOM   2490 O O   . PHE A 1 405 ? -8.221  14.491  -20.032 1.00 157.00 ? 331  PHE A O   1 
ATOM   2491 C CB  . PHE A 1 405 ? -7.919  15.399  -17.101 1.00 201.56 ? 331  PHE A CB  1 
ATOM   2492 C CG  . PHE A 1 405 ? -7.665  16.785  -16.601 1.00 202.68 ? 331  PHE A CG  1 
ATOM   2493 C CD1 . PHE A 1 405 ? -8.543  17.379  -15.712 1.00 202.78 ? 331  PHE A CD1 1 
ATOM   2494 C CD2 . PHE A 1 405 ? -6.553  17.500  -17.020 1.00 198.26 ? 331  PHE A CD2 1 
ATOM   2495 C CE1 . PHE A 1 405 ? -8.321  18.659  -15.247 1.00 215.03 ? 331  PHE A CE1 1 
ATOM   2496 C CE2 . PHE A 1 405 ? -6.323  18.783  -16.557 1.00 219.07 ? 331  PHE A CE2 1 
ATOM   2497 C CZ  . PHE A 1 405 ? -7.209  19.363  -15.669 1.00 216.66 ? 331  PHE A CZ  1 
ATOM   2498 N N   . ARG A 1 406 ? -9.481  13.032  -18.869 1.00 170.59 ? 332  ARG A N   1 
ATOM   2499 C CA  . ARG A 1 406 ? -9.135  11.907  -19.726 1.00 166.52 ? 332  ARG A CA  1 
ATOM   2500 C C   . ARG A 1 406 ? -10.307 11.379  -20.536 1.00 168.07 ? 332  ARG A C   1 
ATOM   2501 O O   . ARG A 1 406 ? -10.194 11.254  -21.762 1.00 193.67 ? 332  ARG A O   1 
ATOM   2502 C CB  . ARG A 1 406 ? -8.527  10.806  -18.851 1.00 196.71 ? 332  ARG A CB  1 
ATOM   2503 C CG  . ARG A 1 406 ? -7.344  11.330  -18.020 1.00 194.67 ? 332  ARG A CG  1 
ATOM   2504 C CD  . ARG A 1 406 ? -6.307  10.263  -17.747 1.00 188.70 ? 332  ARG A CD  1 
ATOM   2505 N NE  . ARG A 1 406 ? -6.082  9.454   -18.936 1.00 212.17 ? 332  ARG A NE  1 
ATOM   2506 C CZ  . ARG A 1 406 ? -5.682  8.192   -18.922 1.00 214.44 ? 332  ARG A CZ  1 
ATOM   2507 N NH1 . ARG A 1 406 ? -5.325  7.594   -17.799 1.00 212.80 ? 332  ARG A NH1 1 
ATOM   2508 N NH2 . ARG A 1 406 ? -5.653  7.511   -20.063 1.00 185.98 ? 332  ARG A NH2 1 
ATOM   2509 N N   . ASN A 1 407 ? -11.434 11.071  -19.900 1.00 153.00 ? 333  ASN A N   1 
ATOM   2510 C CA  . ASN A 1 407 ? -12.590 10.540  -20.618 1.00 183.46 ? 333  ASN A CA  1 
ATOM   2511 C C   . ASN A 1 407 ? -13.259 11.668  -21.397 1.00 196.93 ? 333  ASN A C   1 
ATOM   2512 O O   . ASN A 1 407 ? -13.894 12.549  -20.808 1.00 185.75 ? 333  ASN A O   1 
ATOM   2513 C CB  . ASN A 1 407 ? -13.562 9.890   -19.638 1.00 176.70 ? 333  ASN A CB  1 
ATOM   2514 C CG  . ASN A 1 407 ? -14.643 9.085   -20.333 1.00 175.87 ? 333  ASN A CG  1 
ATOM   2515 O OD1 . ASN A 1 407 ? -15.504 9.640   -21.017 1.00 190.69 ? 333  ASN A OD1 1 
ATOM   2516 N ND2 . ASN A 1 407 ? -14.611 7.767   -20.151 1.00 201.64 ? 333  ASN A ND2 1 
ATOM   2517 N N   . GLN A 1 408 ? -13.119 11.640  -22.725 1.00 196.57 ? 334  GLN A N   1 
ATOM   2518 C CA  . GLN A 1 408 ? -13.606 12.742  -23.551 1.00 189.74 ? 334  GLN A CA  1 
ATOM   2519 C C   . GLN A 1 408 ? -15.131 12.800  -23.567 1.00 183.48 ? 334  GLN A C   1 
ATOM   2520 O O   . GLN A 1 408 ? -15.717 13.892  -23.592 1.00 171.87 ? 334  GLN A O   1 
ATOM   2521 C CB  . GLN A 1 408 ? -13.057 12.602  -24.974 1.00 188.88 ? 334  GLN A CB  1 
ATOM   2522 C CG  . GLN A 1 408 ? -11.531 12.523  -25.060 1.00 182.50 ? 334  GLN A CG  1 
ATOM   2523 C CD  . GLN A 1 408 ? -10.842 13.806  -24.623 1.00 186.04 ? 334  GLN A CD  1 
ATOM   2524 O OE1 . GLN A 1 408 ? -11.183 14.896  -25.081 1.00 191.62 ? 334  GLN A OE1 1 
ATOM   2525 N NE2 . GLN A 1 408 ? -9.866  13.678  -23.732 1.00 182.55 ? 334  GLN A NE2 1 
ATOM   2526 N N   . GLU A 1 409 ? -15.790 11.638  -23.547 1.00 180.62 ? 335  GLU A N   1 
ATOM   2527 C CA  . GLU A 1 409 ? -17.244 11.604  -23.681 1.00 181.43 ? 335  GLU A CA  1 
ATOM   2528 C C   . GLU A 1 409 ? -17.917 12.413  -22.577 1.00 199.86 ? 335  GLU A C   1 
ATOM   2529 O O   . GLU A 1 409 ? -18.835 13.199  -22.839 1.00 191.25 ? 335  GLU A O   1 
ATOM   2530 C CB  . GLU A 1 409 ? -17.735 10.154  -23.665 1.00 172.89 ? 335  GLU A CB  1 
ATOM   2531 C CG  . GLU A 1 409 ? -17.121 9.270   -24.748 1.00 205.42 ? 335  GLU A CG  1 
ATOM   2532 C CD  . GLU A 1 409 ? -17.343 9.808   -26.153 1.00 214.77 ? 335  GLU A CD  1 
ATOM   2533 O OE1 . GLU A 1 409 ? -18.452 10.307  -26.438 1.00 228.56 ? 335  GLU A OE1 1 
ATOM   2534 O OE2 . GLU A 1 409 ? -16.403 9.736   -26.974 1.00 213.47 ? 335  GLU A OE2 1 
ATOM   2535 N N   . ILE A 1 410 ? -17.471 12.239  -21.334 1.00 184.79 ? 336  ILE A N   1 
ATOM   2536 C CA  . ILE A 1 410 ? -18.069 12.974  -20.221 1.00 172.67 ? 336  ILE A CA  1 
ATOM   2537 C C   . ILE A 1 410 ? -17.511 14.399  -20.130 1.00 188.67 ? 336  ILE A C   1 
ATOM   2538 O O   . ILE A 1 410 ? -18.209 15.326  -19.677 1.00 179.39 ? 336  ILE A O   1 
ATOM   2539 C CB  . ILE A 1 410 ? -17.857 12.182  -18.918 1.00 177.53 ? 336  ILE A CB  1 
ATOM   2540 C CG1 . ILE A 1 410 ? -18.469 12.930  -17.735 1.00 190.73 ? 336  ILE A CG1 1 
ATOM   2541 C CG2 . ILE A 1 410 ? -16.371 11.901  -18.688 1.00 183.12 ? 336  ILE A CG2 1 
ATOM   2542 C CD1 . ILE A 1 410 ? -18.660 12.068  -16.507 1.00 172.60 ? 336  ILE A CD1 1 
ATOM   2543 N N   . GLN A 1 411 ? -16.263 14.601  -20.558 1.00 181.95 ? 337  GLN A N   1 
ATOM   2544 C CA  . GLN A 1 411 ? -15.716 15.951  -20.656 1.00 189.29 ? 337  GLN A CA  1 
ATOM   2545 C C   . GLN A 1 411 ? -16.595 16.834  -21.536 1.00 207.76 ? 337  GLN A C   1 
ATOM   2546 O O   . GLN A 1 411 ? -16.746 18.045  -21.277 1.00 208.65 ? 337  GLN A O   1 
ATOM   2547 C CB  . GLN A 1 411 ? -14.290 15.871  -21.207 1.00 194.66 ? 337  GLN A CB  1 
ATOM   2548 C CG  . GLN A 1 411 ? -13.530 17.179  -21.228 1.00 177.68 ? 337  GLN A CG  1 
ATOM   2549 C CD  . GLN A 1 411 ? -12.121 17.014  -21.769 1.00 192.34 ? 337  GLN A CD  1 
ATOM   2550 O OE1 . GLN A 1 411 ? -11.845 16.099  -22.546 1.00 174.54 ? 337  GLN A OE1 1 
ATOM   2551 N NE2 . GLN A 1 411 ? -11.220 17.896  -21.353 1.00 187.90 ? 337  GLN A NE2 1 
ATOM   2552 N N   . ARG A 1 412 ? -17.191 16.239  -22.572 1.00 212.90 ? 338  ARG A N   1 
ATOM   2553 C CA  . ARG A 1 412 ? -18.112 16.979  -23.426 1.00 200.44 ? 338  ARG A CA  1 
ATOM   2554 C C   . ARG A 1 412 ? -19.222 17.621  -22.602 1.00 213.20 ? 338  ARG A C   1 
ATOM   2555 O O   . ARG A 1 412 ? -19.446 18.836  -22.673 1.00 227.61 ? 338  ARG A O   1 
ATOM   2556 C CB  . ARG A 1 412 ? -18.701 16.043  -24.482 1.00 199.63 ? 338  ARG A CB  1 
ATOM   2557 N N   . ALA A 1 413 ? -19.911 16.820  -21.786 1.00 214.48 ? 339  ALA A N   1 
ATOM   2558 C CA  . ALA A 1 413 ? -20.985 17.368  -20.967 1.00 214.13 ? 339  ALA A CA  1 
ATOM   2559 C C   . ALA A 1 413 ? -20.447 18.400  -19.992 1.00 208.11 ? 339  ALA A C   1 
ATOM   2560 O O   . ALA A 1 413 ? -21.118 19.398  -19.701 1.00 213.41 ? 339  ALA A O   1 
ATOM   2561 C CB  . ALA A 1 413 ? -21.703 16.254  -20.210 1.00 182.27 ? 339  ALA A CB  1 
ATOM   2562 N N   . LEU A 1 414 ? -19.236 18.179  -19.476 1.00 218.69 ? 340  LEU A N   1 
ATOM   2563 C CA  . LEU A 1 414 ? -18.661 19.154  -18.553 1.00 225.84 ? 340  LEU A CA  1 
ATOM   2564 C C   . LEU A 1 414 ? -18.645 20.543  -19.181 1.00 229.53 ? 340  LEU A C   1 
ATOM   2565 O O   . LEU A 1 414 ? -19.021 21.533  -18.542 1.00 237.93 ? 340  LEU A O   1 
ATOM   2566 C CB  . LEU A 1 414 ? -17.247 18.743  -18.142 1.00 214.96 ? 340  LEU A CB  1 
ATOM   2567 C CG  . LEU A 1 414 ? -16.552 19.709  -17.174 1.00 199.33 ? 340  LEU A CG  1 
ATOM   2568 C CD1 . LEU A 1 414 ? -17.235 19.710  -15.813 1.00 195.41 ? 340  LEU A CD1 1 
ATOM   2569 C CD2 . LEU A 1 414 ? -15.078 19.368  -17.035 1.00 197.96 ? 340  LEU A CD2 1 
ATOM   2570 N N   . TRP A 1 415 ? -18.211 20.633  -20.438 1.00 228.82 ? 341  TRP A N   1 
ATOM   2571 C CA  . TRP A 1 415 ? -18.182 21.941  -21.094 1.00 224.53 ? 341  TRP A CA  1 
ATOM   2572 C C   . TRP A 1 415 ? -19.528 22.340  -21.702 1.00 237.19 ? 341  TRP A C   1 
ATOM   2573 O O   . TRP A 1 415 ? -19.683 23.493  -22.119 1.00 229.03 ? 341  TRP A O   1 
ATOM   2574 C CB  . TRP A 1 415 ? -17.089 21.964  -22.168 1.00 229.92 ? 341  TRP A CB  1 
ATOM   2575 C CG  . TRP A 1 415 ? -15.700 21.856  -21.597 1.00 214.20 ? 341  TRP A CG  1 
ATOM   2576 C CD1 . TRP A 1 415 ? -15.358 21.861  -20.276 1.00 207.47 ? 341  TRP A CD1 1 
ATOM   2577 C CD2 . TRP A 1 415 ? -14.472 21.727  -22.328 1.00 206.01 ? 341  TRP A CD2 1 
ATOM   2578 N NE1 . TRP A 1 415 ? -13.998 21.744  -20.138 1.00 219.56 ? 341  TRP A NE1 1 
ATOM   2579 C CE2 . TRP A 1 415 ? -13.430 21.659  -21.382 1.00 197.04 ? 341  TRP A CE2 1 
ATOM   2580 C CE3 . TRP A 1 415 ? -14.152 21.662  -23.687 1.00 202.43 ? 341  TRP A CE3 1 
ATOM   2581 C CZ2 . TRP A 1 415 ? -12.092 21.530  -21.751 1.00 186.75 ? 341  TRP A CZ2 1 
ATOM   2582 C CZ3 . TRP A 1 415 ? -12.822 21.533  -24.052 1.00 202.22 ? 341  TRP A CZ3 1 
ATOM   2583 C CH2 . TRP A 1 415 ? -11.810 21.469  -23.088 1.00 177.66 ? 341  TRP A CH2 1 
ATOM   2584 N N   . LEU A 1 416 ? -20.497 21.421  -21.746 1.00 238.81 ? 342  LEU A N   1 
ATOM   2585 C CA  . LEU A 1 416 ? -21.785 21.702  -22.383 1.00 232.94 ? 342  LEU A CA  1 
ATOM   2586 C C   . LEU A 1 416 ? -22.565 22.811  -21.672 1.00 237.36 ? 342  LEU A C   1 
ATOM   2587 O O   . LEU A 1 416 ? -23.192 23.658  -22.325 1.00 244.09 ? 342  LEU A O   1 
ATOM   2588 C CB  . LEU A 1 416 ? -22.604 20.411  -22.429 1.00 216.31 ? 342  LEU A CB  1 
ATOM   2589 C CG  . LEU A 1 416 ? -24.019 20.468  -22.998 1.00 225.47 ? 342  LEU A CG  1 
ATOM   2590 C CD1 . LEU A 1 416 ? -24.023 21.104  -24.375 1.00 225.22 ? 342  LEU A CD1 1 
ATOM   2591 C CD2 . LEU A 1 416 ? -24.603 19.064  -23.051 1.00 216.81 ? 342  LEU A CD2 1 
ATOM   2592 N N   . LEU A 1 417 ? -22.562 22.815  -20.335 1.00 238.73 ? 343  LEU A N   1 
ATOM   2593 C CA  . LEU A 1 417 ? -23.374 23.791  -19.611 1.00 239.99 ? 343  LEU A CA  1 
ATOM   2594 C C   . LEU A 1 417 ? -22.989 25.219  -19.970 1.00 246.33 ? 343  LEU A C   1 
ATOM   2595 O O   . LEU A 1 417 ? -23.852 26.105  -20.000 1.00 285.90 ? 343  LEU A O   1 
ATOM   2596 C CB  . LEU A 1 417 ? -23.244 23.585  -18.102 1.00 231.57 ? 343  LEU A CB  1 
ATOM   2597 C CG  . LEU A 1 417 ? -23.800 24.717  -17.226 1.00 214.94 ? 343  LEU A CG  1 
ATOM   2598 C CD1 . LEU A 1 417 ? -25.301 24.887  -17.423 1.00 210.57 ? 343  LEU A CD1 1 
ATOM   2599 C CD2 . LEU A 1 417 ? -23.477 24.466  -15.766 1.00 194.29 ? 343  LEU A CD2 1 
ATOM   2600 N N   . LEU A 1 418 ? -21.704 25.468  -20.232 1.00 242.56 ? 344  LEU A N   1 
ATOM   2601 C CA  . LEU A 1 418 ? -21.279 26.811  -20.609 1.00 236.50 ? 344  LEU A CA  1 
ATOM   2602 C C   . LEU A 1 418 ? -22.007 27.273  -21.864 1.00 239.33 ? 344  LEU A C   1 
ATOM   2603 O O   . LEU A 1 418 ? -22.440 28.429  -21.949 1.00 244.01 ? 344  LEU A O   1 
ATOM   2604 C CB  . LEU A 1 418 ? -19.765 26.846  -20.814 1.00 228.78 ? 344  LEU A CB  1 
ATOM   2605 N N   . ASP A 1 419 ? -22.159 26.382  -22.848 1.00 249.53 ? 345  ASP A N   1 
ATOM   2606 C CA  . ASP A 1 419 ? -23.061 26.673  -23.957 1.00 237.94 ? 345  ASP A CA  1 
ATOM   2607 C C   . ASP A 1 419 ? -24.469 26.901  -23.432 1.00 238.11 ? 345  ASP A C   1 
ATOM   2608 O O   . ASP A 1 419 ? -25.199 27.765  -23.931 1.00 234.44 ? 345  ASP A O   1 
ATOM   2609 C CB  . ASP A 1 419 ? -23.045 25.531  -24.976 1.00 216.55 ? 345  ASP A CB  1 
ATOM   2610 C CG  . ASP A 1 419 ? -23.839 25.854  -26.231 1.00 209.62 ? 345  ASP A CG  1 
ATOM   2611 O OD1 . ASP A 1 419 ? -24.334 26.994  -26.348 1.00 211.11 ? 345  ASP A OD1 1 
ATOM   2612 O OD2 . ASP A 1 419 ? -23.969 24.967  -27.101 1.00 206.18 ? 345  ASP A OD2 1 
ATOM   2613 N N   . GLY A 1 420 ? -24.861 26.133  -22.413 1.00 248.66 ? 346  GLY A N   1 
ATOM   2614 C CA  . GLY A 1 420 ? -26.123 26.404  -21.743 1.00 242.09 ? 346  GLY A CA  1 
ATOM   2615 C C   . GLY A 1 420 ? -26.152 27.769  -21.078 1.00 238.98 ? 346  GLY A C   1 
ATOM   2616 O O   . GLY A 1 420 ? -27.169 28.465  -21.113 1.00 245.45 ? 346  GLY A O   1 
ATOM   2617 N N   . CYS A 1 421 ? -25.039 28.169  -20.465 1.00 247.86 ? 347  CYS A N   1 
ATOM   2618 C CA  . CYS A 1 421 ? -24.956 29.461  -19.784 1.00 214.48 ? 347  CYS A CA  1 
ATOM   2619 C C   . CYS A 1 421 ? -24.070 30.427  -20.562 1.00 215.92 ? 347  CYS A C   1 
ATOM   2620 O O   . CYS A 1 421 ? -24.277 30.647  -21.754 1.00 228.66 ? 347  CYS A O   1 
ATOM   2621 C CB  . CYS A 1 421 ? -24.419 29.289  -18.361 1.00 203.40 ? 347  CYS A CB  1 
ATOM   2622 S SG  . CYS A 1 421 ? -25.523 28.389  -17.244 1.00 191.86 ? 347  CYS A SG  1 
HETATM 2623 C C2  . X7T B 2 .   ? -9.328  1.682   5.607   1.00 136.32 ? 1201 X7T A C2  1 
HETATM 2624 C C5  . X7T B 2 .   ? -11.328 0.861   7.340   1.00 128.98 ? 1201 X7T A C5  1 
HETATM 2625 C C1  . X7T B 2 .   ? -9.199  0.519   6.349   1.00 132.82 ? 1201 X7T A C1  1 
HETATM 2626 C C3  . X7T B 2 .   ? -10.480 2.445   5.730   1.00 154.37 ? 1201 X7T A C3  1 
HETATM 2627 C C4  . X7T B 2 .   ? -11.481 2.039   6.610   1.00 144.51 ? 1201 X7T A C4  1 
HETATM 2628 O O2  . X7T B 2 .   ? -12.226 11.009  3.541   1.00 139.90 ? 1201 X7T A O2  1 
HETATM 2629 O O3  . X7T B 2 .   ? -11.707 13.004  12.258  1.00 196.14 ? 1201 X7T A O3  1 
HETATM 2630 O O1  . X7T B 2 .   ? -12.639 2.807   6.716   1.00 152.32 ? 1201 X7T A O1  1 
HETATM 2631 C C10 . X7T B 2 .   ? -14.064 5.736   8.579   1.00 112.70 ? 1201 X7T A C10 1 
HETATM 2632 C C11 . X7T B 2 .   ? -13.991 4.393   7.866   1.00 146.14 ? 1201 X7T A C11 1 
HETATM 2633 C C12 . X7T B 2 .   ? -13.254 8.015   8.551   1.00 127.60 ? 1201 X7T A C12 1 
HETATM 2634 C C13 . X7T B 2 .   ? -13.810 9.302   10.396  1.00 171.81 ? 1201 X7T A C13 1 
HETATM 2635 C C14 . X7T B 2 .   ? -14.360 9.339   11.792  1.00 169.82 ? 1201 X7T A C14 1 
HETATM 2636 C C15 . X7T B 2 .   ? -14.639 10.757  12.264  1.00 188.39 ? 1201 X7T A C15 1 
HETATM 2637 C C16 . X7T B 2 .   ? -13.465 11.802  10.390  1.00 174.16 ? 1201 X7T A C16 1 
HETATM 2638 C C17 . X7T B 2 .   ? -13.389 10.452  9.730   1.00 172.13 ? 1201 X7T A C17 1 
HETATM 2639 C C18 . X7T B 2 .   ? -12.817 9.178   7.884   1.00 153.58 ? 1201 X7T A C18 1 
HETATM 2640 C C19 . X7T B 2 .   ? -12.894 9.936   5.528   1.00 141.82 ? 1201 X7T A C19 1 
HETATM 2641 C C20 . X7T B 2 .   ? -11.824 10.806  4.900   1.00 153.87 ? 1201 X7T A C20 1 
HETATM 2642 C C21 . X7T B 2 .   ? -13.377 10.191  3.284   1.00 158.64 ? 1201 X7T A C21 1 
HETATM 2643 C C22 . X7T B 2 .   ? -13.373 9.129   4.352   1.00 147.89 ? 1201 X7T A C22 1 
HETATM 2644 C C23 . X7T B 2 .   ? -12.605 12.285  12.674  1.00 189.95 ? 1201 X7T A C23 1 
HETATM 2645 C C24 . X7T B 2 .   ? -12.722 12.070  14.165  1.00 199.13 ? 1201 X7T A C24 1 
HETATM 2646 C C6  . X7T B 2 .   ? -10.186 0.088   7.222   1.00 128.91 ? 1201 X7T A C6  1 
HETATM 2647 C C7  . X7T B 2 .   ? -12.557 3.934   7.608   1.00 154.19 ? 1201 X7T A C7  1 
HETATM 2648 C C8  . X7T B 2 .   ? -11.779 5.045   6.912   1.00 152.73 ? 1201 X7T A C8  1 
HETATM 2649 C C9  . X7T B 2 .   ? -11.784 6.294   7.768   1.00 136.92 ? 1201 X7T A C9  1 
HETATM 2650 F F1  . X7T B 2 .   ? -8.084  -0.193  6.204   1.00 125.83 ? 1201 X7T A F1  1 
HETATM 2651 F F2  . X7T B 2 .   ? -12.296 0.481   8.177   1.00 130.48 ? 1201 X7T A F2  1 
HETATM 2652 N N1  . X7T B 2 .   ? -13.175 6.729   7.957   1.00 136.17 ? 1201 X7T A N1  1 
HETATM 2653 N N2  . X7T B 2 .   ? -13.740 8.099   9.808   1.00 144.09 ? 1201 X7T A N2  1 
HETATM 2654 N N3  . X7T B 2 .   ? -13.540 11.643  11.847  1.00 177.29 ? 1201 X7T A N3  1 
HETATM 2655 N N4  . X7T B 2 .   ? -12.897 10.389  8.480   1.00 157.62 ? 1201 X7T A N4  1 
HETATM 2656 N N5  . X7T B 2 .   ? -12.314 9.101   6.572   1.00 156.20 ? 1201 X7T A N5  1 
# 
