data_8S6S
# 
_entry.id   8S6S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8S6S         pdb_00008s6s 10.2210/pdb8s6s/pdb 
WWPDB D_1292136919 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-12 ? 
2 'Structure model' 1 1 2025-05-14 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8S6S 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-28 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 maha@bio.dtu.dk Maher         'Abou Hachem' ? 'principal investigator/group leader' 0000-0001-8250-1842 
3 premo@dtu.dk    'Jens Preben' Morth         ? 'principal investigator/group leader' 0000-0003-4077-0192 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Banerjee, S.'    1 ? 
'Turella, S.'     2 ? 
'Morth, J.P.'     3 ? 
'Abou Hachem, M.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                3467 
_citation.page_last                 3467 
_citation.title                     
'Enzymatic oxidation of galacturonides from pectin breakdown contributes to stealth infection by Oomycota phytopathogens.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-58668-8 
_citation.pdbx_database_id_PubMed   40216756 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Turella, S.'              1  0000-0002-3411-4837 
primary 'He, C.'                   2  0000-0002-6148-7487 
primary 'Zhao, L.'                 3  ?                   
primary 'Banerjee, S.'             4  ?                   
primary 'Plouhinec, L.'            5  ?                   
primary 'Assiah Yao, R.'           6  ?                   
primary 'Norgaard Kejlstrup, M.C.' 7  ?                   
primary 'Grisel, S.'               8  0000-0001-6983-0107 
primary 'So, Y.'                   9  0000-0002-4310-012X 
primary 'Annic, B.'                10 0009-0003-6404-6358 
primary 'Fanuel, M.'               11 ?                   
primary 'Haddad Momeni, M.'        12 0000-0001-9653-1380 
primary 'Bissaro, B.'              13 0000-0001-8354-3892 
primary 'Meier, S.'                14 0000-0003-3761-3217 
primary 'Morth, J.P.'              15 0000-0003-4077-0192 
primary 'Dong, S.'                 16 0000-0002-9623-6776 
primary 'Berrin, J.G.'             17 0000-0001-7570-3745 
primary 'Abou Hachem, M.'          18 0000-0001-8250-1842 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Mucin-like protein' 20307.682 2   ? ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL       62.068    2   ? ? ? ? 
3 non-polymer syn 'COPPER (II) ION'    63.546    2   ? ? ? ? 
4 non-polymer nat 'SULFATE ION'        96.063    2   ? ? ? ? 
5 non-polymer syn GLYCEROL             92.094    1   ? ? ? ? 
6 water       nat water                18.015    366 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;HGYIAKPEPSWKDKKTNDWVVEIEPQWKGGWDESKGDEGLLATFKELSAANNYKDVRSLMDGNPVYGEDCGFTDPKGKPV
APPTDGTATFSRGIVHAGPCEIWLDDKMVLQNDDCQSAYGDGTQETIAVFKPVDYSSCASGGCMLRFYWLALQRLDGKTV
WQAYKNCIPLTGPAGWSHPQFEK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;HGYIAKPEPSWKDKKTNDWVVEIEPQWKGGWDESKGDEGLLATFKELSAANNYKDVRSLMDGNPVYGEDCGFTDPKGKPV
APPTDGTATFSRGIVHAGPCEIWLDDKMVLQNDDCQSAYGDGTQETIAVFKPVDYSSCASGGCMLRFYWLALQRLDGKTV
WQAYKNCIPLTGPAGWSHPQFEK
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL    EDO 
3 'COPPER (II) ION' CU  
4 'SULFATE ION'     SO4 
5 GLYCEROL          GOL 
6 water             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   GLY n 
1 3   TYR n 
1 4   ILE n 
1 5   ALA n 
1 6   LYS n 
1 7   PRO n 
1 8   GLU n 
1 9   PRO n 
1 10  SER n 
1 11  TRP n 
1 12  LYS n 
1 13  ASP n 
1 14  LYS n 
1 15  LYS n 
1 16  THR n 
1 17  ASN n 
1 18  ASP n 
1 19  TRP n 
1 20  VAL n 
1 21  VAL n 
1 22  GLU n 
1 23  ILE n 
1 24  GLU n 
1 25  PRO n 
1 26  GLN n 
1 27  TRP n 
1 28  LYS n 
1 29  GLY n 
1 30  GLY n 
1 31  TRP n 
1 32  ASP n 
1 33  GLU n 
1 34  SER n 
1 35  LYS n 
1 36  GLY n 
1 37  ASP n 
1 38  GLU n 
1 39  GLY n 
1 40  LEU n 
1 41  LEU n 
1 42  ALA n 
1 43  THR n 
1 44  PHE n 
1 45  LYS n 
1 46  GLU n 
1 47  LEU n 
1 48  SER n 
1 49  ALA n 
1 50  ALA n 
1 51  ASN n 
1 52  ASN n 
1 53  TYR n 
1 54  LYS n 
1 55  ASP n 
1 56  VAL n 
1 57  ARG n 
1 58  SER n 
1 59  LEU n 
1 60  MET n 
1 61  ASP n 
1 62  GLY n 
1 63  ASN n 
1 64  PRO n 
1 65  VAL n 
1 66  TYR n 
1 67  GLY n 
1 68  GLU n 
1 69  ASP n 
1 70  CYS n 
1 71  GLY n 
1 72  PHE n 
1 73  THR n 
1 74  ASP n 
1 75  PRO n 
1 76  LYS n 
1 77  GLY n 
1 78  LYS n 
1 79  PRO n 
1 80  VAL n 
1 81  ALA n 
1 82  PRO n 
1 83  PRO n 
1 84  THR n 
1 85  ASP n 
1 86  GLY n 
1 87  THR n 
1 88  ALA n 
1 89  THR n 
1 90  PHE n 
1 91  SER n 
1 92  ARG n 
1 93  GLY n 
1 94  ILE n 
1 95  VAL n 
1 96  HIS n 
1 97  ALA n 
1 98  GLY n 
1 99  PRO n 
1 100 CYS n 
1 101 GLU n 
1 102 ILE n 
1 103 TRP n 
1 104 LEU n 
1 105 ASP n 
1 106 ASP n 
1 107 LYS n 
1 108 MET n 
1 109 VAL n 
1 110 LEU n 
1 111 GLN n 
1 112 ASN n 
1 113 ASP n 
1 114 ASP n 
1 115 CYS n 
1 116 GLN n 
1 117 SER n 
1 118 ALA n 
1 119 TYR n 
1 120 GLY n 
1 121 ASP n 
1 122 GLY n 
1 123 THR n 
1 124 GLN n 
1 125 GLU n 
1 126 THR n 
1 127 ILE n 
1 128 ALA n 
1 129 VAL n 
1 130 PHE n 
1 131 LYS n 
1 132 PRO n 
1 133 VAL n 
1 134 ASP n 
1 135 TYR n 
1 136 SER n 
1 137 SER n 
1 138 CYS n 
1 139 ALA n 
1 140 SER n 
1 141 GLY n 
1 142 GLY n 
1 143 CYS n 
1 144 MET n 
1 145 LEU n 
1 146 ARG n 
1 147 PHE n 
1 148 TYR n 
1 149 TRP n 
1 150 LEU n 
1 151 ALA n 
1 152 LEU n 
1 153 GLN n 
1 154 ARG n 
1 155 LEU n 
1 156 ASP n 
1 157 GLY n 
1 158 LYS n 
1 159 THR n 
1 160 VAL n 
1 161 TRP n 
1 162 GLN n 
1 163 ALA n 
1 164 TYR n 
1 165 LYS n 
1 166 ASN n 
1 167 CYS n 
1 168 ILE n 
1 169 PRO n 
1 170 LEU n 
1 171 THR n 
1 172 GLY n 
1 173 PRO n 
1 174 ALA n 
1 175 GLY n 
1 176 TRP n 
1 177 SER n 
1 178 HIS n 
1 179 PRO n 
1 180 GLN n 
1 181 PHE n 
1 182 GLU n 
1 183 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   183 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PHYSODRAFT_483955 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Phytophthora sojae' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     67593 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE           ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE          ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE        ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'   ?                               'C4 H7 N O4'     133.103 
CU  non-polymer         . 'COPPER (II) ION' ?                               'Cu 2'           63.546  
CYS 'L-peptide linking' y CYSTEINE          ?                               'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL    'ETHYLENE GLYCOL'               'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE         ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'   ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE           ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL          'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE         ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER             ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE        ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE           ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE            ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE        ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE     ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE           ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE            ?                               'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'     ?                               'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE         ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN        ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE          ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE            ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   24  1   HIS HIS A . n 
A 1 2   GLY 2   25  2   GLY GLY A . n 
A 1 3   TYR 3   26  3   TYR TYR A . n 
A 1 4   ILE 4   27  4   ILE ILE A . n 
A 1 5   ALA 5   28  5   ALA ALA A . n 
A 1 6   LYS 6   29  6   LYS LYS A . n 
A 1 7   PRO 7   30  7   PRO PRO A . n 
A 1 8   GLU 8   31  8   GLU GLU A . n 
A 1 9   PRO 9   32  9   PRO PRO A . n 
A 1 10  SER 10  33  10  SER SER A . n 
A 1 11  TRP 11  34  11  TRP TRP A . n 
A 1 12  LYS 12  35  12  LYS LYS A . n 
A 1 13  ASP 13  36  13  ASP ASP A . n 
A 1 14  LYS 14  37  14  LYS LYS A . n 
A 1 15  LYS 15  38  15  LYS LYS A . n 
A 1 16  THR 16  39  16  THR THR A . n 
A 1 17  ASN 17  40  17  ASN ASN A . n 
A 1 18  ASP 18  41  18  ASP ASP A . n 
A 1 19  TRP 19  42  19  TRP TRP A . n 
A 1 20  VAL 20  43  20  VAL VAL A . n 
A 1 21  VAL 21  44  21  VAL VAL A . n 
A 1 22  GLU 22  45  22  GLU GLU A . n 
A 1 23  ILE 23  46  23  ILE ILE A . n 
A 1 24  GLU 24  47  24  GLU GLU A . n 
A 1 25  PRO 25  48  25  PRO PRO A . n 
A 1 26  GLN 26  49  26  GLN GLN A . n 
A 1 27  TRP 27  50  27  TRP TRP A . n 
A 1 28  LYS 28  51  28  LYS LYS A . n 
A 1 29  GLY 29  52  29  GLY GLY A . n 
A 1 30  GLY 30  53  30  GLY GLY A . n 
A 1 31  TRP 31  54  31  TRP TRP A . n 
A 1 32  ASP 32  55  32  ASP ASP A . n 
A 1 33  GLU 33  56  33  GLU GLU A . n 
A 1 34  SER 34  57  34  SER SER A . n 
A 1 35  LYS 35  58  35  LYS LYS A . n 
A 1 36  GLY 36  59  36  GLY GLY A . n 
A 1 37  ASP 37  60  37  ASP ASP A . n 
A 1 38  GLU 38  61  38  GLU GLU A . n 
A 1 39  GLY 39  62  39  GLY GLY A . n 
A 1 40  LEU 40  63  40  LEU LEU A . n 
A 1 41  LEU 41  64  41  LEU LEU A . n 
A 1 42  ALA 42  65  42  ALA ALA A . n 
A 1 43  THR 43  66  43  THR THR A . n 
A 1 44  PHE 44  67  44  PHE PHE A . n 
A 1 45  LYS 45  68  45  LYS LYS A . n 
A 1 46  GLU 46  69  46  GLU GLU A . n 
A 1 47  LEU 47  70  47  LEU LEU A . n 
A 1 48  SER 48  71  48  SER SER A . n 
A 1 49  ALA 49  72  49  ALA ALA A . n 
A 1 50  ALA 50  73  50  ALA ALA A . n 
A 1 51  ASN 51  74  51  ASN ASN A . n 
A 1 52  ASN 52  75  52  ASN ASN A . n 
A 1 53  TYR 53  76  53  TYR TYR A . n 
A 1 54  LYS 54  77  54  LYS LYS A . n 
A 1 55  ASP 55  78  55  ASP ASP A . n 
A 1 56  VAL 56  79  56  VAL VAL A . n 
A 1 57  ARG 57  80  57  ARG ARG A . n 
A 1 58  SER 58  81  58  SER SER A . n 
A 1 59  LEU 59  82  59  LEU LEU A . n 
A 1 60  MET 60  83  60  MET MET A . n 
A 1 61  ASP 61  84  61  ASP ASP A . n 
A 1 62  GLY 62  85  62  GLY GLY A . n 
A 1 63  ASN 63  86  63  ASN ASN A . n 
A 1 64  PRO 64  87  64  PRO PRO A . n 
A 1 65  VAL 65  88  65  VAL VAL A . n 
A 1 66  TYR 66  89  66  TYR TYR A . n 
A 1 67  GLY 67  90  67  GLY GLY A . n 
A 1 68  GLU 68  91  68  GLU GLU A . n 
A 1 69  ASP 69  92  69  ASP ASP A . n 
A 1 70  CYS 70  93  70  CYS CYS A . n 
A 1 71  GLY 71  94  71  GLY GLY A . n 
A 1 72  PHE 72  95  72  PHE PHE A . n 
A 1 73  THR 73  96  73  THR THR A . n 
A 1 74  ASP 74  97  74  ASP ASP A . n 
A 1 75  PRO 75  98  75  PRO PRO A . n 
A 1 76  LYS 76  99  76  LYS LYS A . n 
A 1 77  GLY 77  100 77  GLY GLY A . n 
A 1 78  LYS 78  101 78  LYS LYS A . n 
A 1 79  PRO 79  102 79  PRO PRO A . n 
A 1 80  VAL 80  103 80  VAL VAL A . n 
A 1 81  ALA 81  104 81  ALA ALA A . n 
A 1 82  PRO 82  105 82  PRO PRO A . n 
A 1 83  PRO 83  106 83  PRO PRO A . n 
A 1 84  THR 84  107 84  THR THR A . n 
A 1 85  ASP 85  108 85  ASP ASP A . n 
A 1 86  GLY 86  109 86  GLY GLY A . n 
A 1 87  THR 87  110 87  THR THR A . n 
A 1 88  ALA 88  111 88  ALA ALA A . n 
A 1 89  THR 89  112 89  THR THR A . n 
A 1 90  PHE 90  113 90  PHE PHE A . n 
A 1 91  SER 91  114 91  SER SER A . n 
A 1 92  ARG 92  115 92  ARG ARG A . n 
A 1 93  GLY 93  116 93  GLY GLY A . n 
A 1 94  ILE 94  117 94  ILE ILE A . n 
A 1 95  VAL 95  118 95  VAL VAL A . n 
A 1 96  HIS 96  119 96  HIS HIS A . n 
A 1 97  ALA 97  120 97  ALA ALA A . n 
A 1 98  GLY 98  121 98  GLY GLY A . n 
A 1 99  PRO 99  122 99  PRO PRO A . n 
A 1 100 CYS 100 123 100 CYS CYS A . n 
A 1 101 GLU 101 124 101 GLU GLU A . n 
A 1 102 ILE 102 125 102 ILE ILE A . n 
A 1 103 TRP 103 126 103 TRP TRP A . n 
A 1 104 LEU 104 127 104 LEU LEU A . n 
A 1 105 ASP 105 128 105 ASP ASP A . n 
A 1 106 ASP 106 129 106 ASP ASP A . n 
A 1 107 LYS 107 130 107 LYS LYS A . n 
A 1 108 MET 108 131 108 MET MET A . n 
A 1 109 VAL 109 132 109 VAL VAL A . n 
A 1 110 LEU 110 133 110 LEU LEU A . n 
A 1 111 GLN 111 134 111 GLN GLN A . n 
A 1 112 ASN 112 135 112 ASN ASN A . n 
A 1 113 ASP 113 136 113 ASP ASP A . n 
A 1 114 ASP 114 137 114 ASP ASP A . n 
A 1 115 CYS 115 138 115 CYS CYS A . n 
A 1 116 GLN 116 139 116 GLN GLN A . n 
A 1 117 SER 117 140 117 SER SER A . n 
A 1 118 ALA 118 141 118 ALA ALA A . n 
A 1 119 TYR 119 142 119 TYR TYR A . n 
A 1 120 GLY 120 143 120 GLY GLY A . n 
A 1 121 ASP 121 144 121 ASP ASP A . n 
A 1 122 GLY 122 145 122 GLY GLY A . n 
A 1 123 THR 123 146 123 THR THR A . n 
A 1 124 GLN 124 147 124 GLN GLN A . n 
A 1 125 GLU 125 148 125 GLU GLU A . n 
A 1 126 THR 126 149 126 THR THR A . n 
A 1 127 ILE 127 150 127 ILE ILE A . n 
A 1 128 ALA 128 151 128 ALA ALA A . n 
A 1 129 VAL 129 152 129 VAL VAL A . n 
A 1 130 PHE 130 153 130 PHE PHE A . n 
A 1 131 LYS 131 154 131 LYS LYS A . n 
A 1 132 PRO 132 155 132 PRO PRO A . n 
A 1 133 VAL 133 156 133 VAL VAL A . n 
A 1 134 ASP 134 157 134 ASP ASP A . n 
A 1 135 TYR 135 158 135 TYR TYR A . n 
A 1 136 SER 136 159 136 SER SER A . n 
A 1 137 SER 137 160 137 SER SER A . n 
A 1 138 CYS 138 161 138 CYS CYS A . n 
A 1 139 ALA 139 162 139 ALA ALA A . n 
A 1 140 SER 140 163 140 SER SER A . n 
A 1 141 GLY 141 164 141 GLY GLY A . n 
A 1 142 GLY 142 165 142 GLY GLY A . n 
A 1 143 CYS 143 166 143 CYS CYS A . n 
A 1 144 MET 144 167 144 MET MET A . n 
A 1 145 LEU 145 168 145 LEU LEU A . n 
A 1 146 ARG 146 169 146 ARG ARG A . n 
A 1 147 PHE 147 170 147 PHE PHE A . n 
A 1 148 TYR 148 171 148 TYR TYR A . n 
A 1 149 TRP 149 172 149 TRP TRP A . n 
A 1 150 LEU 150 173 150 LEU LEU A . n 
A 1 151 ALA 151 174 151 ALA ALA A . n 
A 1 152 LEU 152 175 152 LEU LEU A . n 
A 1 153 GLN 153 176 153 GLN GLN A . n 
A 1 154 ARG 154 177 154 ARG ARG A . n 
A 1 155 LEU 155 178 155 LEU LEU A . n 
A 1 156 ASP 156 179 156 ASP ASP A . n 
A 1 157 GLY 157 180 157 GLY GLY A . n 
A 1 158 LYS 158 181 158 LYS LYS A . n 
A 1 159 THR 159 182 159 THR THR A . n 
A 1 160 VAL 160 183 160 VAL VAL A . n 
A 1 161 TRP 161 184 161 TRP TRP A . n 
A 1 162 GLN 162 185 162 GLN GLN A . n 
A 1 163 ALA 163 186 163 ALA ALA A . n 
A 1 164 TYR 164 187 164 TYR TYR A . n 
A 1 165 LYS 165 188 165 LYS LYS A . n 
A 1 166 ASN 166 189 166 ASN ASN A . n 
A 1 167 CYS 167 190 167 CYS CYS A . n 
A 1 168 ILE 168 191 168 ILE ILE A . n 
A 1 169 PRO 169 192 169 PRO PRO A . n 
A 1 170 LEU 170 193 170 LEU LEU A . n 
A 1 171 THR 171 194 171 THR THR A . n 
A 1 172 GLY 172 195 172 GLY GLY A . n 
A 1 173 PRO 173 196 173 PRO PRO A . n 
A 1 174 ALA 174 197 ?   ?   ?   A . n 
A 1 175 GLY 175 198 ?   ?   ?   A . n 
A 1 176 TRP 176 199 ?   ?   ?   A . n 
A 1 177 SER 177 200 ?   ?   ?   A . n 
A 1 178 HIS 178 201 ?   ?   ?   A . n 
A 1 179 PRO 179 202 ?   ?   ?   A . n 
A 1 180 GLN 180 203 ?   ?   ?   A . n 
A 1 181 PHE 181 204 ?   ?   ?   A . n 
A 1 182 GLU 182 205 ?   ?   ?   A . n 
A 1 183 LYS 183 206 ?   ?   ?   A . n 
B 1 1   HIS 1   24  1   HIS HIS B . n 
B 1 2   GLY 2   25  2   GLY GLY B . n 
B 1 3   TYR 3   26  3   TYR TYR B . n 
B 1 4   ILE 4   27  4   ILE ILE B . n 
B 1 5   ALA 5   28  5   ALA ALA B . n 
B 1 6   LYS 6   29  6   LYS LYS B . n 
B 1 7   PRO 7   30  7   PRO PRO B . n 
B 1 8   GLU 8   31  8   GLU GLU B . n 
B 1 9   PRO 9   32  9   PRO PRO B . n 
B 1 10  SER 10  33  10  SER SER B . n 
B 1 11  TRP 11  34  11  TRP TRP B . n 
B 1 12  LYS 12  35  12  LYS LYS B . n 
B 1 13  ASP 13  36  13  ASP ASP B . n 
B 1 14  LYS 14  37  14  LYS LYS B . n 
B 1 15  LYS 15  38  15  LYS LYS B . n 
B 1 16  THR 16  39  16  THR THR B . n 
B 1 17  ASN 17  40  17  ASN ASN B . n 
B 1 18  ASP 18  41  18  ASP ASP B . n 
B 1 19  TRP 19  42  19  TRP TRP B . n 
B 1 20  VAL 20  43  20  VAL VAL B . n 
B 1 21  VAL 21  44  21  VAL VAL B . n 
B 1 22  GLU 22  45  22  GLU GLU B . n 
B 1 23  ILE 23  46  23  ILE ILE B . n 
B 1 24  GLU 24  47  24  GLU GLU B . n 
B 1 25  PRO 25  48  25  PRO PRO B . n 
B 1 26  GLN 26  49  26  GLN GLN B . n 
B 1 27  TRP 27  50  27  TRP TRP B . n 
B 1 28  LYS 28  51  28  LYS LYS B . n 
B 1 29  GLY 29  52  29  GLY GLY B . n 
B 1 30  GLY 30  53  30  GLY GLY B . n 
B 1 31  TRP 31  54  31  TRP TRP B . n 
B 1 32  ASP 32  55  32  ASP ASP B . n 
B 1 33  GLU 33  56  33  GLU GLU B . n 
B 1 34  SER 34  57  34  SER SER B . n 
B 1 35  LYS 35  58  35  LYS LYS B . n 
B 1 36  GLY 36  59  36  GLY GLY B . n 
B 1 37  ASP 37  60  37  ASP ASP B . n 
B 1 38  GLU 38  61  38  GLU GLU B . n 
B 1 39  GLY 39  62  39  GLY GLY B . n 
B 1 40  LEU 40  63  40  LEU LEU B . n 
B 1 41  LEU 41  64  41  LEU LEU B . n 
B 1 42  ALA 42  65  42  ALA ALA B . n 
B 1 43  THR 43  66  43  THR THR B . n 
B 1 44  PHE 44  67  44  PHE PHE B . n 
B 1 45  LYS 45  68  45  LYS LYS B . n 
B 1 46  GLU 46  69  46  GLU GLU B . n 
B 1 47  LEU 47  70  47  LEU LEU B . n 
B 1 48  SER 48  71  48  SER SER B . n 
B 1 49  ALA 49  72  49  ALA ALA B . n 
B 1 50  ALA 50  73  50  ALA ALA B . n 
B 1 51  ASN 51  74  51  ASN ASN B . n 
B 1 52  ASN 52  75  52  ASN ASN B . n 
B 1 53  TYR 53  76  53  TYR TYR B . n 
B 1 54  LYS 54  77  54  LYS LYS B . n 
B 1 55  ASP 55  78  55  ASP ASP B . n 
B 1 56  VAL 56  79  56  VAL VAL B . n 
B 1 57  ARG 57  80  57  ARG ARG B . n 
B 1 58  SER 58  81  58  SER SER B . n 
B 1 59  LEU 59  82  59  LEU LEU B . n 
B 1 60  MET 60  83  60  MET MET B . n 
B 1 61  ASP 61  84  61  ASP ASP B . n 
B 1 62  GLY 62  85  62  GLY GLY B . n 
B 1 63  ASN 63  86  63  ASN ASN B . n 
B 1 64  PRO 64  87  64  PRO PRO B . n 
B 1 65  VAL 65  88  65  VAL VAL B . n 
B 1 66  TYR 66  89  66  TYR TYR B . n 
B 1 67  GLY 67  90  67  GLY GLY B . n 
B 1 68  GLU 68  91  68  GLU GLU B . n 
B 1 69  ASP 69  92  69  ASP ASP B . n 
B 1 70  CYS 70  93  70  CYS CYS B . n 
B 1 71  GLY 71  94  71  GLY GLY B . n 
B 1 72  PHE 72  95  72  PHE PHE B . n 
B 1 73  THR 73  96  73  THR THR B . n 
B 1 74  ASP 74  97  74  ASP ASP B . n 
B 1 75  PRO 75  98  75  PRO PRO B . n 
B 1 76  LYS 76  99  76  LYS LYS B . n 
B 1 77  GLY 77  100 77  GLY GLY B . n 
B 1 78  LYS 78  101 78  LYS LYS B . n 
B 1 79  PRO 79  102 79  PRO PRO B . n 
B 1 80  VAL 80  103 80  VAL VAL B . n 
B 1 81  ALA 81  104 81  ALA ALA B . n 
B 1 82  PRO 82  105 82  PRO PRO B . n 
B 1 83  PRO 83  106 83  PRO PRO B . n 
B 1 84  THR 84  107 84  THR THR B . n 
B 1 85  ASP 85  108 85  ASP ASP B . n 
B 1 86  GLY 86  109 86  GLY GLY B . n 
B 1 87  THR 87  110 87  THR THR B . n 
B 1 88  ALA 88  111 88  ALA ALA B . n 
B 1 89  THR 89  112 89  THR THR B . n 
B 1 90  PHE 90  113 90  PHE PHE B . n 
B 1 91  SER 91  114 91  SER SER B . n 
B 1 92  ARG 92  115 92  ARG ARG B . n 
B 1 93  GLY 93  116 93  GLY GLY B . n 
B 1 94  ILE 94  117 94  ILE ILE B . n 
B 1 95  VAL 95  118 95  VAL VAL B . n 
B 1 96  HIS 96  119 96  HIS HIS B . n 
B 1 97  ALA 97  120 97  ALA ALA B . n 
B 1 98  GLY 98  121 98  GLY GLY B . n 
B 1 99  PRO 99  122 99  PRO PRO B . n 
B 1 100 CYS 100 123 100 CYS CYS B . n 
B 1 101 GLU 101 124 101 GLU GLU B . n 
B 1 102 ILE 102 125 102 ILE ILE B . n 
B 1 103 TRP 103 126 103 TRP TRP B . n 
B 1 104 LEU 104 127 104 LEU LEU B . n 
B 1 105 ASP 105 128 105 ASP ASP B . n 
B 1 106 ASP 106 129 106 ASP ASP B . n 
B 1 107 LYS 107 130 107 LYS LYS B . n 
B 1 108 MET 108 131 108 MET MET B . n 
B 1 109 VAL 109 132 109 VAL VAL B . n 
B 1 110 LEU 110 133 110 LEU LEU B . n 
B 1 111 GLN 111 134 111 GLN GLN B . n 
B 1 112 ASN 112 135 112 ASN ASN B . n 
B 1 113 ASP 113 136 113 ASP ASP B . n 
B 1 114 ASP 114 137 114 ASP ASP B . n 
B 1 115 CYS 115 138 115 CYS CYS B . n 
B 1 116 GLN 116 139 116 GLN GLN B . n 
B 1 117 SER 117 140 117 SER SER B . n 
B 1 118 ALA 118 141 118 ALA ALA B . n 
B 1 119 TYR 119 142 119 TYR TYR B . n 
B 1 120 GLY 120 143 120 GLY GLY B . n 
B 1 121 ASP 121 144 121 ASP ASP B . n 
B 1 122 GLY 122 145 122 GLY GLY B . n 
B 1 123 THR 123 146 123 THR THR B . n 
B 1 124 GLN 124 147 124 GLN GLN B . n 
B 1 125 GLU 125 148 125 GLU GLU B . n 
B 1 126 THR 126 149 126 THR THR B . n 
B 1 127 ILE 127 150 127 ILE ILE B . n 
B 1 128 ALA 128 151 128 ALA ALA B . n 
B 1 129 VAL 129 152 129 VAL VAL B . n 
B 1 130 PHE 130 153 130 PHE PHE B . n 
B 1 131 LYS 131 154 131 LYS LYS B . n 
B 1 132 PRO 132 155 132 PRO PRO B . n 
B 1 133 VAL 133 156 133 VAL VAL B . n 
B 1 134 ASP 134 157 134 ASP ASP B . n 
B 1 135 TYR 135 158 135 TYR TYR B . n 
B 1 136 SER 136 159 136 SER SER B . n 
B 1 137 SER 137 160 137 SER SER B . n 
B 1 138 CYS 138 161 138 CYS CYS B . n 
B 1 139 ALA 139 162 139 ALA ALA B . n 
B 1 140 SER 140 163 140 SER SER B . n 
B 1 141 GLY 141 164 141 GLY GLY B . n 
B 1 142 GLY 142 165 142 GLY GLY B . n 
B 1 143 CYS 143 166 143 CYS CYS B . n 
B 1 144 MET 144 167 144 MET MET B . n 
B 1 145 LEU 145 168 145 LEU LEU B . n 
B 1 146 ARG 146 169 146 ARG ARG B . n 
B 1 147 PHE 147 170 147 PHE PHE B . n 
B 1 148 TYR 148 171 148 TYR TYR B . n 
B 1 149 TRP 149 172 149 TRP TRP B . n 
B 1 150 LEU 150 173 150 LEU LEU B . n 
B 1 151 ALA 151 174 151 ALA ALA B . n 
B 1 152 LEU 152 175 152 LEU LEU B . n 
B 1 153 GLN 153 176 153 GLN GLN B . n 
B 1 154 ARG 154 177 154 ARG ARG B . n 
B 1 155 LEU 155 178 155 LEU LEU B . n 
B 1 156 ASP 156 179 156 ASP ASP B . n 
B 1 157 GLY 157 180 157 GLY GLY B . n 
B 1 158 LYS 158 181 158 LYS LYS B . n 
B 1 159 THR 159 182 159 THR THR B . n 
B 1 160 VAL 160 183 160 VAL VAL B . n 
B 1 161 TRP 161 184 161 TRP TRP B . n 
B 1 162 GLN 162 185 162 GLN GLN B . n 
B 1 163 ALA 163 186 163 ALA ALA B . n 
B 1 164 TYR 164 187 164 TYR TYR B . n 
B 1 165 LYS 165 188 165 LYS LYS B . n 
B 1 166 ASN 166 189 166 ASN ASN B . n 
B 1 167 CYS 167 190 167 CYS CYS B . n 
B 1 168 ILE 168 191 168 ILE ILE B . n 
B 1 169 PRO 169 192 169 PRO PRO B . n 
B 1 170 LEU 170 193 170 LEU LEU B . n 
B 1 171 THR 171 194 171 THR THR B . n 
B 1 172 GLY 172 195 172 GLY GLY B . n 
B 1 173 PRO 173 196 173 PRO PRO B . n 
B 1 174 ALA 174 197 ?   ?   ?   B . n 
B 1 175 GLY 175 198 ?   ?   ?   B . n 
B 1 176 TRP 176 199 ?   ?   ?   B . n 
B 1 177 SER 177 200 ?   ?   ?   B . n 
B 1 178 HIS 178 201 ?   ?   ?   B . n 
B 1 179 PRO 179 202 ?   ?   ?   B . n 
B 1 180 GLN 180 203 ?   ?   ?   B . n 
B 1 181 PHE 181 204 ?   ?   ?   B . n 
B 1 182 GLU 182 205 ?   ?   ?   B . n 
B 1 183 LYS 183 206 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        CU 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   CU 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 EDO 1   301 201 EDO EDO A . 
D 3 CU  1   302 301 CU  CU  A . 
E 2 EDO 1   303 302 EDO EDO A . 
F 4 SO4 1   304 1   SO4 SO4 A . 
G 4 SO4 1   305 2   SO4 SO4 A . 
H 5 GOL 1   301 201 GOL GOL B . 
I 3 CU  1   302 301 CU  CU  B . 
J 6 HOH 1   401 306 HOH HOH A . 
J 6 HOH 2   402 375 HOH HOH A . 
J 6 HOH 3   403 402 HOH HOH A . 
J 6 HOH 4   404 301 HOH HOH A . 
J 6 HOH 5   405 388 HOH HOH A . 
J 6 HOH 6   406 332 HOH HOH A . 
J 6 HOH 7   407 340 HOH HOH A . 
J 6 HOH 8   408 346 HOH HOH A . 
J 6 HOH 9   409 116 HOH HOH A . 
J 6 HOH 10  410 398 HOH HOH A . 
J 6 HOH 11  411 80  HOH HOH A . 
J 6 HOH 12  412 370 HOH HOH A . 
J 6 HOH 13  413 368 HOH HOH A . 
J 6 HOH 14  414 202 HOH HOH A . 
J 6 HOH 15  415 151 HOH HOH A . 
J 6 HOH 16  416 47  HOH HOH A . 
J 6 HOH 17  417 328 HOH HOH A . 
J 6 HOH 18  418 361 HOH HOH A . 
J 6 HOH 19  419 71  HOH HOH A . 
J 6 HOH 20  420 200 HOH HOH A . 
J 6 HOH 21  421 418 HOH HOH A . 
J 6 HOH 22  422 297 HOH HOH A . 
J 6 HOH 23  423 99  HOH HOH A . 
J 6 HOH 24  424 81  HOH HOH A . 
J 6 HOH 25  425 86  HOH HOH A . 
J 6 HOH 26  426 188 HOH HOH A . 
J 6 HOH 27  427 327 HOH HOH A . 
J 6 HOH 28  428 34  HOH HOH A . 
J 6 HOH 29  429 414 HOH HOH A . 
J 6 HOH 30  430 281 HOH HOH A . 
J 6 HOH 31  431 265 HOH HOH A . 
J 6 HOH 32  432 405 HOH HOH A . 
J 6 HOH 33  433 115 HOH HOH A . 
J 6 HOH 34  434 14  HOH HOH A . 
J 6 HOH 35  435 165 HOH HOH A . 
J 6 HOH 36  436 159 HOH HOH A . 
J 6 HOH 37  437 52  HOH HOH A . 
J 6 HOH 38  438 293 HOH HOH A . 
J 6 HOH 39  439 350 HOH HOH A . 
J 6 HOH 40  440 72  HOH HOH A . 
J 6 HOH 41  441 321 HOH HOH A . 
J 6 HOH 42  442 107 HOH HOH A . 
J 6 HOH 43  443 319 HOH HOH A . 
J 6 HOH 44  444 7   HOH HOH A . 
J 6 HOH 45  445 21  HOH HOH A . 
J 6 HOH 46  446 347 HOH HOH A . 
J 6 HOH 47  447 79  HOH HOH A . 
J 6 HOH 48  448 305 HOH HOH A . 
J 6 HOH 49  449 119 HOH HOH A . 
J 6 HOH 50  450 257 HOH HOH A . 
J 6 HOH 51  451 31  HOH HOH A . 
J 6 HOH 52  452 8   HOH HOH A . 
J 6 HOH 53  453 108 HOH HOH A . 
J 6 HOH 54  454 209 HOH HOH A . 
J 6 HOH 55  455 320 HOH HOH A . 
J 6 HOH 56  456 70  HOH HOH A . 
J 6 HOH 57  457 266 HOH HOH A . 
J 6 HOH 58  458 25  HOH HOH A . 
J 6 HOH 59  459 68  HOH HOH A . 
J 6 HOH 60  460 185 HOH HOH A . 
J 6 HOH 61  461 190 HOH HOH A . 
J 6 HOH 62  462 399 HOH HOH A . 
J 6 HOH 63  463 258 HOH HOH A . 
J 6 HOH 64  464 5   HOH HOH A . 
J 6 HOH 65  465 411 HOH HOH A . 
J 6 HOH 66  466 384 HOH HOH A . 
J 6 HOH 67  467 93  HOH HOH A . 
J 6 HOH 68  468 121 HOH HOH A . 
J 6 HOH 69  469 172 HOH HOH A . 
J 6 HOH 70  470 1   HOH HOH A . 
J 6 HOH 71  471 233 HOH HOH A . 
J 6 HOH 72  472 46  HOH HOH A . 
J 6 HOH 73  473 173 HOH HOH A . 
J 6 HOH 74  474 111 HOH HOH A . 
J 6 HOH 75  475 44  HOH HOH A . 
J 6 HOH 76  476 139 HOH HOH A . 
J 6 HOH 77  477 114 HOH HOH A . 
J 6 HOH 78  478 20  HOH HOH A . 
J 6 HOH 79  479 169 HOH HOH A . 
J 6 HOH 80  480 291 HOH HOH A . 
J 6 HOH 81  481 23  HOH HOH A . 
J 6 HOH 82  482 304 HOH HOH A . 
J 6 HOH 83  483 313 HOH HOH A . 
J 6 HOH 84  484 18  HOH HOH A . 
J 6 HOH 85  485 95  HOH HOH A . 
J 6 HOH 86  486 113 HOH HOH A . 
J 6 HOH 87  487 164 HOH HOH A . 
J 6 HOH 88  488 36  HOH HOH A . 
J 6 HOH 89  489 182 HOH HOH A . 
J 6 HOH 90  490 397 HOH HOH A . 
J 6 HOH 91  491 333 HOH HOH A . 
J 6 HOH 92  492 168 HOH HOH A . 
J 6 HOH 93  493 161 HOH HOH A . 
J 6 HOH 94  494 199 HOH HOH A . 
J 6 HOH 95  495 94  HOH HOH A . 
J 6 HOH 96  496 49  HOH HOH A . 
J 6 HOH 97  497 401 HOH HOH A . 
J 6 HOH 98  498 42  HOH HOH A . 
J 6 HOH 99  499 364 HOH HOH A . 
J 6 HOH 100 500 348 HOH HOH A . 
J 6 HOH 101 501 50  HOH HOH A . 
J 6 HOH 102 502 43  HOH HOH A . 
J 6 HOH 103 503 167 HOH HOH A . 
J 6 HOH 104 504 123 HOH HOH A . 
J 6 HOH 105 505 177 HOH HOH A . 
J 6 HOH 106 506 162 HOH HOH A . 
J 6 HOH 107 507 90  HOH HOH A . 
J 6 HOH 108 508 307 HOH HOH A . 
J 6 HOH 109 509 374 HOH HOH A . 
J 6 HOH 110 510 124 HOH HOH A . 
J 6 HOH 111 511 290 HOH HOH A . 
J 6 HOH 112 512 128 HOH HOH A . 
J 6 HOH 113 513 41  HOH HOH A . 
J 6 HOH 114 514 138 HOH HOH A . 
J 6 HOH 115 515 294 HOH HOH A . 
J 6 HOH 116 516 238 HOH HOH A . 
J 6 HOH 117 517 158 HOH HOH A . 
J 6 HOH 118 518 382 HOH HOH A . 
J 6 HOH 119 519 298 HOH HOH A . 
J 6 HOH 120 520 381 HOH HOH A . 
J 6 HOH 121 521 137 HOH HOH A . 
J 6 HOH 122 522 97  HOH HOH A . 
J 6 HOH 123 523 191 HOH HOH A . 
J 6 HOH 124 524 61  HOH HOH A . 
J 6 HOH 125 525 89  HOH HOH A . 
J 6 HOH 126 526 284 HOH HOH A . 
J 6 HOH 127 527 67  HOH HOH A . 
J 6 HOH 128 528 29  HOH HOH A . 
J 6 HOH 129 529 357 HOH HOH A . 
J 6 HOH 130 530 187 HOH HOH A . 
J 6 HOH 131 531 120 HOH HOH A . 
J 6 HOH 132 532 63  HOH HOH A . 
J 6 HOH 133 533 142 HOH HOH A . 
J 6 HOH 134 534 66  HOH HOH A . 
J 6 HOH 135 535 391 HOH HOH A . 
J 6 HOH 136 536 410 HOH HOH A . 
J 6 HOH 137 537 59  HOH HOH A . 
J 6 HOH 138 538 214 HOH HOH A . 
J 6 HOH 139 539 155 HOH HOH A . 
J 6 HOH 140 540 174 HOH HOH A . 
J 6 HOH 141 541 40  HOH HOH A . 
J 6 HOH 142 542 143 HOH HOH A . 
J 6 HOH 143 543 231 HOH HOH A . 
J 6 HOH 144 544 341 HOH HOH A . 
J 6 HOH 145 545 299 HOH HOH A . 
J 6 HOH 146 546 356 HOH HOH A . 
J 6 HOH 147 547 92  HOH HOH A . 
J 6 HOH 148 548 296 HOH HOH A . 
J 6 HOH 149 549 3   HOH HOH A . 
J 6 HOH 150 550 396 HOH HOH A . 
J 6 HOH 151 551 292 HOH HOH A . 
J 6 HOH 152 552 300 HOH HOH A . 
J 6 HOH 153 553 149 HOH HOH A . 
J 6 HOH 154 554 192 HOH HOH A . 
J 6 HOH 155 555 334 HOH HOH A . 
J 6 HOH 156 556 73  HOH HOH A . 
J 6 HOH 157 557 154 HOH HOH A . 
J 6 HOH 158 558 264 HOH HOH A . 
J 6 HOH 159 559 275 HOH HOH A . 
J 6 HOH 160 560 392 HOH HOH A . 
J 6 HOH 161 561 240 HOH HOH A . 
J 6 HOH 162 562 365 HOH HOH A . 
J 6 HOH 163 563 377 HOH HOH A . 
J 6 HOH 164 564 378 HOH HOH A . 
J 6 HOH 165 565 412 HOH HOH A . 
J 6 HOH 166 566 371 HOH HOH A . 
J 6 HOH 167 567 400 HOH HOH A . 
J 6 HOH 168 568 407 HOH HOH A . 
J 6 HOH 169 569 245 HOH HOH A . 
J 6 HOH 170 570 308 HOH HOH A . 
J 6 HOH 171 571 150 HOH HOH A . 
J 6 HOH 172 572 314 HOH HOH A . 
J 6 HOH 173 573 408 HOH HOH A . 
J 6 HOH 174 574 183 HOH HOH A . 
J 6 HOH 175 575 383 HOH HOH A . 
J 6 HOH 176 576 210 HOH HOH A . 
J 6 HOH 177 577 339 HOH HOH A . 
J 6 HOH 178 578 360 HOH HOH A . 
J 6 HOH 179 579 129 HOH HOH A . 
J 6 HOH 180 580 379 HOH HOH A . 
J 6 HOH 181 581 419 HOH HOH A . 
J 6 HOH 182 582 141 HOH HOH A . 
J 6 HOH 183 583 131 HOH HOH A . 
J 6 HOH 184 584 380 HOH HOH A . 
J 6 HOH 185 585 178 HOH HOH A . 
J 6 HOH 186 586 317 HOH HOH A . 
J 6 HOH 187 587 394 HOH HOH A . 
J 6 HOH 188 588 289 HOH HOH A . 
J 6 HOH 189 589 415 HOH HOH A . 
J 6 HOH 190 590 406 HOH HOH A . 
J 6 HOH 191 591 117 HOH HOH A . 
J 6 HOH 192 592 148 HOH HOH A . 
K 6 HOH 1   401 358 HOH HOH B . 
K 6 HOH 2   402 326 HOH HOH B . 
K 6 HOH 3   403 372 HOH HOH B . 
K 6 HOH 4   404 133 HOH HOH B . 
K 6 HOH 5   405 322 HOH HOH B . 
K 6 HOH 6   406 65  HOH HOH B . 
K 6 HOH 7   407 386 HOH HOH B . 
K 6 HOH 8   408 351 HOH HOH B . 
K 6 HOH 9   409 48  HOH HOH B . 
K 6 HOH 10  410 416 HOH HOH B . 
K 6 HOH 11  411 105 HOH HOH B . 
K 6 HOH 12  412 215 HOH HOH B . 
K 6 HOH 13  413 324 HOH HOH B . 
K 6 HOH 14  414 387 HOH HOH B . 
K 6 HOH 15  415 249 HOH HOH B . 
K 6 HOH 16  416 166 HOH HOH B . 
K 6 HOH 17  417 325 HOH HOH B . 
K 6 HOH 18  418 228 HOH HOH B . 
K 6 HOH 19  419 272 HOH HOH B . 
K 6 HOH 20  420 338 HOH HOH B . 
K 6 HOH 21  421 39  HOH HOH B . 
K 6 HOH 22  422 87  HOH HOH B . 
K 6 HOH 23  423 104 HOH HOH B . 
K 6 HOH 24  424 77  HOH HOH B . 
K 6 HOH 25  425 6   HOH HOH B . 
K 6 HOH 26  426 153 HOH HOH B . 
K 6 HOH 27  427 250 HOH HOH B . 
K 6 HOH 28  428 27  HOH HOH B . 
K 6 HOH 29  429 243 HOH HOH B . 
K 6 HOH 30  430 16  HOH HOH B . 
K 6 HOH 31  431 118 HOH HOH B . 
K 6 HOH 32  432 4   HOH HOH B . 
K 6 HOH 33  433 260 HOH HOH B . 
K 6 HOH 34  434 274 HOH HOH B . 
K 6 HOH 35  435 344 HOH HOH B . 
K 6 HOH 36  436 10  HOH HOH B . 
K 6 HOH 37  437 160 HOH HOH B . 
K 6 HOH 38  438 213 HOH HOH B . 
K 6 HOH 39  439 237 HOH HOH B . 
K 6 HOH 40  440 359 HOH HOH B . 
K 6 HOH 41  441 102 HOH HOH B . 
K 6 HOH 42  442 171 HOH HOH B . 
K 6 HOH 43  443 32  HOH HOH B . 
K 6 HOH 44  444 125 HOH HOH B . 
K 6 HOH 45  445 189 HOH HOH B . 
K 6 HOH 46  446 354 HOH HOH B . 
K 6 HOH 47  447 22  HOH HOH B . 
K 6 HOH 48  448 235 HOH HOH B . 
K 6 HOH 49  449 278 HOH HOH B . 
K 6 HOH 50  450 363 HOH HOH B . 
K 6 HOH 51  451 38  HOH HOH B . 
K 6 HOH 52  452 336 HOH HOH B . 
K 6 HOH 53  453 147 HOH HOH B . 
K 6 HOH 54  454 91  HOH HOH B . 
K 6 HOH 55  455 60  HOH HOH B . 
K 6 HOH 56  456 82  HOH HOH B . 
K 6 HOH 57  457 331 HOH HOH B . 
K 6 HOH 58  458 229 HOH HOH B . 
K 6 HOH 59  459 198 HOH HOH B . 
K 6 HOH 60  460 157 HOH HOH B . 
K 6 HOH 61  461 62  HOH HOH B . 
K 6 HOH 62  462 355 HOH HOH B . 
K 6 HOH 63  463 323 HOH HOH B . 
K 6 HOH 64  464 330 HOH HOH B . 
K 6 HOH 65  465 57  HOH HOH B . 
K 6 HOH 66  466 385 HOH HOH B . 
K 6 HOH 67  467 84  HOH HOH B . 
K 6 HOH 68  468 196 HOH HOH B . 
K 6 HOH 69  469 64  HOH HOH B . 
K 6 HOH 70  470 204 HOH HOH B . 
K 6 HOH 71  471 83  HOH HOH B . 
K 6 HOH 72  472 103 HOH HOH B . 
K 6 HOH 73  473 53  HOH HOH B . 
K 6 HOH 74  474 55  HOH HOH B . 
K 6 HOH 75  475 51  HOH HOH B . 
K 6 HOH 76  476 33  HOH HOH B . 
K 6 HOH 77  477 24  HOH HOH B . 
K 6 HOH 78  478 273 HOH HOH B . 
K 6 HOH 79  479 126 HOH HOH B . 
K 6 HOH 80  480 343 HOH HOH B . 
K 6 HOH 81  481 156 HOH HOH B . 
K 6 HOH 82  482 2   HOH HOH B . 
K 6 HOH 83  483 127 HOH HOH B . 
K 6 HOH 84  484 17  HOH HOH B . 
K 6 HOH 85  485 345 HOH HOH B . 
K 6 HOH 86  486 201 HOH HOH B . 
K 6 HOH 87  487 145 HOH HOH B . 
K 6 HOH 88  488 244 HOH HOH B . 
K 6 HOH 89  489 130 HOH HOH B . 
K 6 HOH 90  490 136 HOH HOH B . 
K 6 HOH 91  491 96  HOH HOH B . 
K 6 HOH 92  492 69  HOH HOH B . 
K 6 HOH 93  493 88  HOH HOH B . 
K 6 HOH 94  494 134 HOH HOH B . 
K 6 HOH 95  495 262 HOH HOH B . 
K 6 HOH 96  496 78  HOH HOH B . 
K 6 HOH 97  497 184 HOH HOH B . 
K 6 HOH 98  498 373 HOH HOH B . 
K 6 HOH 99  499 409 HOH HOH B . 
K 6 HOH 100 500 15  HOH HOH B . 
K 6 HOH 101 501 56  HOH HOH B . 
K 6 HOH 102 502 226 HOH HOH B . 
K 6 HOH 103 503 276 HOH HOH B . 
K 6 HOH 104 504 309 HOH HOH B . 
K 6 HOH 105 505 98  HOH HOH B . 
K 6 HOH 106 506 246 HOH HOH B . 
K 6 HOH 107 507 208 HOH HOH B . 
K 6 HOH 108 508 28  HOH HOH B . 
K 6 HOH 109 509 109 HOH HOH B . 
K 6 HOH 110 510 75  HOH HOH B . 
K 6 HOH 111 511 30  HOH HOH B . 
K 6 HOH 112 512 362 HOH HOH B . 
K 6 HOH 113 513 254 HOH HOH B . 
K 6 HOH 114 514 144 HOH HOH B . 
K 6 HOH 115 515 58  HOH HOH B . 
K 6 HOH 116 516 35  HOH HOH B . 
K 6 HOH 117 517 179 HOH HOH B . 
K 6 HOH 118 518 366 HOH HOH B . 
K 6 HOH 119 519 404 HOH HOH B . 
K 6 HOH 120 520 367 HOH HOH B . 
K 6 HOH 121 521 112 HOH HOH B . 
K 6 HOH 122 522 212 HOH HOH B . 
K 6 HOH 123 523 85  HOH HOH B . 
K 6 HOH 124 524 13  HOH HOH B . 
K 6 HOH 125 525 106 HOH HOH B . 
K 6 HOH 126 526 152 HOH HOH B . 
K 6 HOH 127 527 54  HOH HOH B . 
K 6 HOH 128 528 140 HOH HOH B . 
K 6 HOH 129 529 11  HOH HOH B . 
K 6 HOH 130 530 337 HOH HOH B . 
K 6 HOH 131 531 12  HOH HOH B . 
K 6 HOH 132 532 76  HOH HOH B . 
K 6 HOH 133 533 288 HOH HOH B . 
K 6 HOH 134 534 393 HOH HOH B . 
K 6 HOH 135 535 302 HOH HOH B . 
K 6 HOH 136 536 311 HOH HOH B . 
K 6 HOH 137 537 342 HOH HOH B . 
K 6 HOH 138 538 417 HOH HOH B . 
K 6 HOH 139 539 349 HOH HOH B . 
K 6 HOH 140 540 239 HOH HOH B . 
K 6 HOH 141 541 403 HOH HOH B . 
K 6 HOH 142 542 335 HOH HOH B . 
K 6 HOH 143 543 279 HOH HOH B . 
K 6 HOH 144 544 310 HOH HOH B . 
K 6 HOH 145 545 353 HOH HOH B . 
K 6 HOH 146 546 135 HOH HOH B . 
K 6 HOH 147 547 100 HOH HOH B . 
K 6 HOH 148 548 232 HOH HOH B . 
K 6 HOH 149 549 181 HOH HOH B . 
K 6 HOH 150 550 219 HOH HOH B . 
K 6 HOH 151 551 352 HOH HOH B . 
K 6 HOH 152 552 19  HOH HOH B . 
K 6 HOH 153 553 413 HOH HOH B . 
K 6 HOH 154 554 163 HOH HOH B . 
K 6 HOH 155 555 369 HOH HOH B . 
K 6 HOH 156 556 395 HOH HOH B . 
K 6 HOH 157 557 194 HOH HOH B . 
K 6 HOH 158 558 122 HOH HOH B . 
K 6 HOH 159 559 390 HOH HOH B . 
K 6 HOH 160 560 110 HOH HOH B . 
K 6 HOH 161 561 329 HOH HOH B . 
K 6 HOH 162 562 227 HOH HOH B . 
K 6 HOH 163 563 211 HOH HOH B . 
K 6 HOH 164 564 248 HOH HOH B . 
K 6 HOH 165 565 376 HOH HOH B . 
K 6 HOH 166 566 225 HOH HOH B . 
K 6 HOH 167 567 175 HOH HOH B . 
K 6 HOH 168 568 312 HOH HOH B . 
K 6 HOH 169 569 224 HOH HOH B . 
K 6 HOH 170 570 389 HOH HOH B . 
K 6 HOH 171 571 222 HOH HOH B . 
K 6 HOH 172 572 242 HOH HOH B . 
K 6 HOH 173 573 270 HOH HOH B . 
K 6 HOH 174 574 230 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 107 ? CG2 ? A THR 84 CG2 
2 1 Y 1 B THR 107 ? CG2 ? B THR 84 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? AutoProcess ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP      ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8S6S 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     46.267 
_cell.length_a_esd                 ? 
_cell.length_b                     73.129 
_cell.length_b_esd                 ? 
_cell.length_c                     116.418 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8S6S 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8S6S 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.57 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          52.19 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Lithium sulfate, 0.1 M Tris pH 8.5, 30% w/v PEG 4000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.98 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.98 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'P13 (MX1)' 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, EMBL c/o DESY' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8S6S 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.789 
_reflns.d_resolution_low                               61.925 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38093 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.789 
_reflns_shell.d_res_low                                     1.82 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1838 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.829 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.746 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            -1.326 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            0.580 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.585 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.971 
_refine.correlation_coeff_Fo_to_Fc_free          0.954 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8S6S 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.789 
_refine.ls_d_res_low                             61.925 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38093 
_refine.ls_number_reflns_R_free                  1905 
_refine.ls_number_reflns_R_work                  36188 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.974 
_refine.ls_percent_reflns_R_free                 5.001 
_refine.ls_R_factor_all                          0.163 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2023 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1608 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.107 
_refine.pdbx_overall_ESU_R_Free                  0.109 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             2.318 
_refine.overall_SU_ML                            0.072 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.789 
_refine_hist.d_res_low                        61.925 
_refine_hist.number_atoms_solvent             366 
_refine_hist.number_atoms_total               3078 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2686 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         26 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.012  2890 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2555 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.560  1.658  3947 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.558  1.594  5963 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 7.218  5.000  372  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 4.984  5.000  8    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.028 10.000 448  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 16.198 10.000 126  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.088  0.200  400  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  3479 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  629  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.218  0.200  532  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.204  0.200  2327 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.185  0.200  1393 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.086  0.200  1471 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.203  0.200  296  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.031  0.200  1    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.055  0.200  4    ? r_metal_ion_refined            ? ? 
'X-RAY DIFFRACTION' ? 0.102  0.200  11   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.149  0.200  45   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.117  0.200  17   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.893  2.747  1449 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.893  2.748  1449 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.144  4.911  1831 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.144  4.915  1832 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 4.634  3.188  1441 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 4.591  3.169  1434 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 7.111  5.565  2115 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 7.072  5.532  2104 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 8.645  29.984 3371 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.637  29.526 3286 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.789 1.835  2755 . 125 2630 100.0000 . 0.230 . . 0.228 . . . . . 0.216 . 20 . 0.963 0.950 0.276 
'X-RAY DIFFRACTION' 1.835 1.885  2707 . 140 2566 99.9631  . 0.197 . . 0.197 . . . . . 0.181 . 20 . 0.972 0.969 0.203 
'X-RAY DIFFRACTION' 1.885 1.940  2627 . 124 2503 100.0000 . 0.183 . . 0.181 . . . . . 0.163 . 20 . 0.977 0.969 0.218 
'X-RAY DIFFRACTION' 1.940 2.000  2551 . 161 2390 100.0000 . 0.171 . . 0.169 . . . . . 0.151 . 20 . 0.982 0.974 0.205 
'X-RAY DIFFRACTION' 2.000 2.065  2484 . 137 2347 100.0000 . 0.162 . . 0.160 . . . . . 0.141 . 20 . 0.984 0.974 0.199 
'X-RAY DIFFRACTION' 2.065 2.138  2390 . 113 2277 100.0000 . 0.165 . . 0.163 . . . . . 0.145 . 20 . 0.983 0.967 0.203 
'X-RAY DIFFRACTION' 2.138 2.218  2358 . 119 2239 100.0000 . 0.162 . . 0.159 . . . . . 0.141 . 20 . 0.984 0.966 0.236 
'X-RAY DIFFRACTION' 2.218 2.309  2224 . 100 2123 99.9550  . 0.156 . . 0.154 . . . . . 0.136 . 20 . 0.985 0.976 0.197 
'X-RAY DIFFRACTION' 2.309 2.411  2168 . 108 2059 99.9539  . 0.150 . . 0.147 . . . . . 0.131 . 20 . 0.987 0.973 0.210 
'X-RAY DIFFRACTION' 2.411 2.529  2030 . 90  1940 100.0000 . 0.140 . . 0.138 . . . . . 0.122 . 20 . 0.989 0.981 0.188 
'X-RAY DIFFRACTION' 2.529 2.665  1981 . 109 1872 100.0000 . 0.150 . . 0.147 . . . . . 0.134 . 20 . 0.987 0.977 0.210 
'X-RAY DIFFRACTION' 2.665 2.827  1854 . 101 1752 99.9461  . 0.165 . . 0.162 . . . . . 0.151 . 20 . 0.984 0.969 0.223 
'X-RAY DIFFRACTION' 2.827 3.021  1771 . 87  1683 99.9435  . 0.177 . . 0.175 . . . . . 0.168 . 20 . 0.981 0.970 0.222 
'X-RAY DIFFRACTION' 3.021 3.263  1649 . 70  1579 100.0000 . 0.185 . . 0.183 . . . . . 0.180 . 20 . 0.982 0.974 0.225 
'X-RAY DIFFRACTION' 3.263 3.573  1516 . 73  1443 100.0000 . 0.170 . . 0.170 . . . . . 0.170 . 20 . 0.985 0.982 0.179 
'X-RAY DIFFRACTION' 3.573 3.993  1376 . 62  1313 99.9273  . 0.147 . . 0.146 . . . . . 0.152 . 20 . 0.989 0.982 0.171 
'X-RAY DIFFRACTION' 3.993 4.608  1251 . 66  1183 99.8401  . 0.129 . . 0.128 . . . . . 0.141 . 20 . 0.991 0.987 0.149 
'X-RAY DIFFRACTION' 4.608 5.636  1056 . 51  1005 100.0000 . 0.145 . . 0.142 . . . . . 0.161 . 20 . 0.990 0.978 0.220 
'X-RAY DIFFRACTION' 5.636 7.937  845  . 47  798  100.0000 . 0.178 . . 0.177 . . . . . 0.198 . 20 . 0.985 0.977 0.196 
'X-RAY DIFFRACTION' 7.937 61.925 510  . 22  486  99.6078  . 0.205 . . 0.202 . . . . . 0.243 . 20 . 0.971 0.927 0.294 
# 
_struct.entry_id                     8S6S 
_struct.title                        'Oxidoreductase from Phytophthora sojae' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8S6S 
_struct_keywords.text            'LPMO, AA17, Phytophthora sojae, phytopathogen, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 3 ? 
J N N 6 ? 
K N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    G4YSM3_PHYSP 
_struct_ref.pdbx_db_accession          G4YSM3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;HGYIAKPEPSWKDKKTNDWVVEIEPQWKGGWDESKGDEGLLATFKELSAANNYKDVRSLMDGNPVYGEDCGFTDPKGKPV
APPTDGTATFSRGIVHAGPCEIWLDDKMVLQNDDCQSAYGDGTQETIAVFKPVDYSSCASGGCMLRFYWLALQRLDGKTV
WQAYKNCIPLTGPAG
;
_struct_ref.pdbx_align_begin           24 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8S6S A 1 ? 175 ? G4YSM3 24 ? 198 ? 24 198 
2 1 8S6S B 1 ? 175 ? G4YSM3 24 ? 198 ? 24 198 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8S6S TRP A 176 ? UNP G4YSM3 ? ? 'expression tag' 199 1  
1 8S6S SER A 177 ? UNP G4YSM3 ? ? 'expression tag' 200 2  
1 8S6S HIS A 178 ? UNP G4YSM3 ? ? 'expression tag' 201 3  
1 8S6S PRO A 179 ? UNP G4YSM3 ? ? 'expression tag' 202 4  
1 8S6S GLN A 180 ? UNP G4YSM3 ? ? 'expression tag' 203 5  
1 8S6S PHE A 181 ? UNP G4YSM3 ? ? 'expression tag' 204 6  
1 8S6S GLU A 182 ? UNP G4YSM3 ? ? 'expression tag' 205 7  
1 8S6S LYS A 183 ? UNP G4YSM3 ? ? 'expression tag' 206 8  
2 8S6S TRP B 176 ? UNP G4YSM3 ? ? 'expression tag' 199 9  
2 8S6S SER B 177 ? UNP G4YSM3 ? ? 'expression tag' 200 10 
2 8S6S HIS B 178 ? UNP G4YSM3 ? ? 'expression tag' 201 11 
2 8S6S PRO B 179 ? UNP G4YSM3 ? ? 'expression tag' 202 12 
2 8S6S GLN B 180 ? UNP G4YSM3 ? ? 'expression tag' 203 13 
2 8S6S PHE B 181 ? UNP G4YSM3 ? ? 'expression tag' 204 14 
2 8S6S GLU B 182 ? UNP G4YSM3 ? ? 'expression tag' 205 15 
2 8S6S LYS B 183 ? UNP G4YSM3 ? ? 'expression tag' 206 16 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1470  ? 
1 MORE         -29   ? 
1 'SSA (A^2)'  17040 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 LYS A 35  ? ALA A 49  ? LYS A 58  ALA A 72  1 ? 15 
HELX_P HELX_P2 AA2 ASP A 55  ? ASP A 61  ? ASP A 78  ASP A 84  1 ? 7  
HELX_P HELX_P3 AA3 ASN A 63  ? GLY A 67  ? ASN A 86  GLY A 90  5 ? 5  
HELX_P HELX_P4 AA4 ASP A 114 ? GLY A 120 ? ASP A 137 GLY A 143 1 ? 7  
HELX_P HELX_P5 AA5 GLY B 30  ? SER B 34  ? GLY B 53  SER B 57  5 ? 5  
HELX_P HELX_P6 AA6 GLY B 36  ? ALA B 50  ? GLY B 59  ALA B 73  1 ? 15 
HELX_P HELX_P7 AA7 ASP B 55  ? ASP B 61  ? ASP B 78  ASP B 84  1 ? 7  
HELX_P HELX_P8 AA8 ASN B 63  ? GLY B 67  ? ASN B 86  GLY B 90  5 ? 5  
HELX_P HELX_P9 AA9 ASP B 114 ? GLY B 120 ? ASP B 137 GLY B 143 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 70  SG  A ? ? 1_555 A CYS 167 SG  A ? A CYS 93  A CYS 190 1_555 ? ? ? ? ? ? ? 2.074 ? ? 
disulf2 disulf ? ? A CYS 138 SG  A ? ? 1_555 A CYS 143 SG  A ? A CYS 161 A CYS 166 1_555 ? ? ? ? ? ? ? 2.066 ? ? 
disulf3 disulf ? ? B CYS 70  SG  A ? ? 1_555 B CYS 167 SG  A ? B CYS 93  B CYS 190 1_555 ? ? ? ? ? ? ? 2.132 ? ? 
disulf4 disulf ? ? B CYS 138 SG  A ? ? 1_555 B CYS 143 SG  A ? B CYS 161 B CYS 166 1_555 ? ? ? ? ? ? ? 2.096 ? ? 
metalc1 metalc ? ? A HIS 1   N   ? ? ? 1_555 D CU  .   CU  ? ? A HIS 24  A CU  302 1_555 ? ? ? ? ? ? ? 2.457 ? ? 
metalc2 metalc ? ? A HIS 1   ND1 ? ? ? 1_555 D CU  .   CU  ? ? A HIS 24  A CU  302 1_555 ? ? ? ? ? ? ? 1.950 ? ? 
metalc3 metalc ? ? A HIS 96  NE2 ? ? ? 1_555 D CU  .   CU  ? ? A HIS 119 A CU  302 1_555 ? ? ? ? ? ? ? 2.017 ? ? 
metalc4 metalc ? ? D CU  .   CU  ? ? ? 4_455 B ASP 156 OD1 ? ? A CU  302 B ASP 179 1_555 ? ? ? ? ? ? ? 2.633 ? ? 
metalc5 metalc ? ? B HIS 1   N   ? ? ? 1_555 I CU  .   CU  ? ? B HIS 24  B CU  302 1_555 ? ? ? ? ? ? ? 2.500 ? ? 
metalc6 metalc ? ? B HIS 1   ND1 ? ? ? 1_555 I CU  .   CU  ? ? B HIS 24  B CU  302 1_555 ? ? ? ? ? ? ? 1.959 ? ? 
metalc7 metalc ? ? B HIS 96  NE2 ? ? ? 1_555 I CU  .   CU  ? ? B HIS 119 B CU  302 1_555 ? ? ? ? ? ? ? 2.016 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 N   ? A HIS 1  ? A HIS 24  ? 1_555 CU ? D CU . ? A CU 302 ? 1_555 ND1 ? A HIS 1   ? A HIS 24  ? 1_555 89.6  ? 
2 N   ? A HIS 1  ? A HIS 24  ? 1_555 CU ? D CU . ? A CU 302 ? 1_555 NE2 ? A HIS 96  ? A HIS 119 ? 1_555 93.0  ? 
3 ND1 ? A HIS 1  ? A HIS 24  ? 1_555 CU ? D CU . ? A CU 302 ? 1_555 NE2 ? A HIS 96  ? A HIS 119 ? 1_555 176.8 ? 
4 N   ? A HIS 1  ? A HIS 24  ? 1_555 CU ? D CU . ? A CU 302 ? 1_555 OD1 ? B ASP 156 ? B ASP 179 ? 1_555 122.8 ? 
5 ND1 ? A HIS 1  ? A HIS 24  ? 1_555 CU ? D CU . ? A CU 302 ? 1_555 OD1 ? B ASP 156 ? B ASP 179 ? 1_555 105.8 ? 
6 NE2 ? A HIS 96 ? A HIS 119 ? 1_555 CU ? D CU . ? A CU 302 ? 1_555 OD1 ? B ASP 156 ? B ASP 179 ? 1_555 74.4  ? 
7 N   ? B HIS 1  ? B HIS 24  ? 1_555 CU ? I CU . ? B CU 302 ? 1_555 ND1 ? B HIS 1   ? B HIS 24  ? 1_555 89.2  ? 
8 N   ? B HIS 1  ? B HIS 24  ? 1_555 CU ? I CU . ? B CU 302 ? 1_555 NE2 ? B HIS 96  ? B HIS 119 ? 1_555 95.3  ? 
9 ND1 ? B HIS 1  ? B HIS 24  ? 1_555 CU ? I CU . ? B CU 302 ? 1_555 NE2 ? B HIS 96  ? B HIS 119 ? 1_555 175.1 ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 70  A CYS A 167 A CYS A 93  ? 1_555 CYS A 190 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 138 A CYS A 143 A CYS A 161 ? 1_555 CYS A 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 70  A CYS B 167 A CYS B 93  ? 1_555 CYS B 190 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 138 A CYS B 143 A CYS B 161 ? 1_555 CYS B 166 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LYS 6   A . ? LYS 29  A PRO 7   A ? PRO 30  A 1 3.72  
2 LYS 131 A . ? LYS 154 A PRO 132 A ? PRO 155 A 1 -2.07 
3 LYS 6   B . ? LYS 29  B PRO 7   B ? PRO 30  B 1 0.22  
4 LYS 131 B . ? LYS 154 B PRO 132 B ? PRO 155 B 1 -6.62 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 4   ? LYS A 6   ? ILE A 27  LYS A 29  
AA1 2 ALA A 88  ? PHE A 90  ? ALA A 111 PHE A 113 
AA1 3 VAL A 129 ? PHE A 130 ? VAL A 152 PHE A 153 
AA2 1 VAL A 21  ? ILE A 23  ? VAL A 44  ILE A 46  
AA2 2 LYS A 158 ? LEU A 170 ? LYS A 181 LEU A 193 
AA2 3 CYS A 143 ? LEU A 155 ? CYS A 166 LEU A 178 
AA2 4 CYS A 100 ? LEU A 104 ? CYS A 123 LEU A 127 
AA2 5 LYS A 107 ? ASN A 112 ? LYS A 130 ASN A 135 
AA3 1 ILE B 4   ? LYS B 6   ? ILE B 27  LYS B 29  
AA3 2 ALA B 88  ? PHE B 90  ? ALA B 111 PHE B 113 
AA3 3 VAL B 129 ? PHE B 130 ? VAL B 152 PHE B 153 
AA4 1 VAL B 21  ? ILE B 23  ? VAL B 44  ILE B 46  
AA4 2 LYS B 158 ? LEU B 170 ? LYS B 181 LEU B 193 
AA4 3 CYS B 143 ? LEU B 155 ? CYS B 166 LEU B 178 
AA4 4 CYS B 100 ? LEU B 104 ? CYS B 123 LEU B 127 
AA4 5 LYS B 107 ? ASN B 112 ? LYS B 130 ASN B 135 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 5   ? N ALA A 28  O THR A 89  ? O THR A 112 
AA1 2 3 N ALA A 88  ? N ALA A 111 O PHE A 130 ? O PHE A 153 
AA2 1 2 N ILE A 23  ? N ILE A 46  O TRP A 161 ? O TRP A 184 
AA2 2 3 O LYS A 158 ? O LYS A 181 N LEU A 155 ? N LEU A 178 
AA2 3 4 O ARG A 146 ? O ARG A 169 N TRP A 103 ? N TRP A 126 
AA2 4 5 N ILE A 102 ? N ILE A 125 O LEU A 110 ? O LEU A 133 
AA3 1 2 N LYS B 6   ? N LYS B 29  O THR B 89  ? O THR B 112 
AA3 2 3 N ALA B 88  ? N ALA B 111 O PHE B 130 ? O PHE B 153 
AA4 1 2 N ILE B 23  ? N ILE B 46  O TRP B 161 ? O TRP B 184 
AA4 2 3 O LEU B 170 ? O LEU B 193 N CYS B 143 ? N CYS B 166 
AA4 3 4 O ARG B 146 ? O ARG B 169 N TRP B 103 ? N TRP B 126 
AA4 4 5 N LEU B 104 ? N LEU B 127 O LYS B 107 ? O LYS B 130 
# 
_pdbx_entry_details.entry_id                   8S6S 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   SG 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   CYS 
_pdbx_validate_close_contact.auth_seq_id_1    123 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   SG 
_pdbx_validate_close_contact.auth_asym_id_2   B 
_pdbx_validate_close_contact.auth_comp_id_2   CYS 
_pdbx_validate_close_contact.auth_seq_id_2    138 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   A 
_pdbx_validate_close_contact.dist             1.68 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_1             148 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OE2 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_2             148 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.321 
_pdbx_validate_rmsd_bond.bond_target_value         1.252 
_pdbx_validate_rmsd_bond.bond_deviation            0.069 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.011 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_1              138 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_2              138 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             C 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_3              138 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                120.44 
_pdbx_validate_rmsd_angle.angle_target_value         111.50 
_pdbx_validate_rmsd_angle.angle_deviation            8.94 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.20 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 36  ? ? -126.19 -87.08  
2 1 CYS A 93  ? ? 76.27   -5.54   
3 1 ASP A 128 ? ? 50.00   -122.48 
4 1 ASP A 128 ? ? 50.00   -117.61 
5 1 ASP B 36  ? ? -121.74 -94.14  
6 1 CYS B 93  ? B 74.16   -8.75   
7 1 ASP B 128 ? ? 47.17   -125.16 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ALA 197 ? A ALA 174 
2  1 Y 1 A GLY 198 ? A GLY 175 
3  1 Y 1 A TRP 199 ? A TRP 176 
4  1 Y 1 A SER 200 ? A SER 177 
5  1 Y 1 A HIS 201 ? A HIS 178 
6  1 Y 1 A PRO 202 ? A PRO 179 
7  1 Y 1 A GLN 203 ? A GLN 180 
8  1 Y 1 A PHE 204 ? A PHE 181 
9  1 Y 1 A GLU 205 ? A GLU 182 
10 1 Y 1 A LYS 206 ? A LYS 183 
11 1 Y 1 B ALA 197 ? B ALA 174 
12 1 Y 1 B GLY 198 ? B GLY 175 
13 1 Y 1 B TRP 199 ? B TRP 176 
14 1 Y 1 B SER 200 ? B SER 177 
15 1 Y 1 B HIS 201 ? B HIS 178 
16 1 Y 1 B PRO 202 ? B PRO 179 
17 1 Y 1 B GLN 203 ? B GLN 180 
18 1 Y 1 B PHE 204 ? B PHE 181 
19 1 Y 1 B GLU 205 ? B GLU 182 
20 1 Y 1 B LYS 206 ? B LYS 183 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CU  CU   CU N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
EDO C1   C  N N 89  
EDO O1   O  N N 90  
EDO C2   C  N N 91  
EDO O2   O  N N 92  
EDO H11  H  N N 93  
EDO H12  H  N N 94  
EDO HO1  H  N N 95  
EDO H21  H  N N 96  
EDO H22  H  N N 97  
EDO HO2  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
GOL C1   C  N N 148 
GOL O1   O  N N 149 
GOL C2   C  N N 150 
GOL O2   O  N N 151 
GOL C3   C  N N 152 
GOL O3   O  N N 153 
GOL H11  H  N N 154 
GOL H12  H  N N 155 
GOL HO1  H  N N 156 
GOL H2   H  N N 157 
GOL HO2  H  N N 158 
GOL H31  H  N N 159 
GOL H32  H  N N 160 
GOL HO3  H  N N 161 
HIS N    N  N N 162 
HIS CA   C  N S 163 
HIS C    C  N N 164 
HIS O    O  N N 165 
HIS CB   C  N N 166 
HIS CG   C  Y N 167 
HIS ND1  N  Y N 168 
HIS CD2  C  Y N 169 
HIS CE1  C  Y N 170 
HIS NE2  N  Y N 171 
HIS OXT  O  N N 172 
HIS H    H  N N 173 
HIS H2   H  N N 174 
HIS HA   H  N N 175 
HIS HB2  H  N N 176 
HIS HB3  H  N N 177 
HIS HD1  H  N N 178 
HIS HD2  H  N N 179 
HIS HE1  H  N N 180 
HIS HE2  H  N N 181 
HIS HXT  H  N N 182 
HOH O    O  N N 183 
HOH H1   H  N N 184 
HOH H2   H  N N 185 
ILE N    N  N N 186 
ILE CA   C  N S 187 
ILE C    C  N N 188 
ILE O    O  N N 189 
ILE CB   C  N S 190 
ILE CG1  C  N N 191 
ILE CG2  C  N N 192 
ILE CD1  C  N N 193 
ILE OXT  O  N N 194 
ILE H    H  N N 195 
ILE H2   H  N N 196 
ILE HA   H  N N 197 
ILE HB   H  N N 198 
ILE HG12 H  N N 199 
ILE HG13 H  N N 200 
ILE HG21 H  N N 201 
ILE HG22 H  N N 202 
ILE HG23 H  N N 203 
ILE HD11 H  N N 204 
ILE HD12 H  N N 205 
ILE HD13 H  N N 206 
ILE HXT  H  N N 207 
LEU N    N  N N 208 
LEU CA   C  N S 209 
LEU C    C  N N 210 
LEU O    O  N N 211 
LEU CB   C  N N 212 
LEU CG   C  N N 213 
LEU CD1  C  N N 214 
LEU CD2  C  N N 215 
LEU OXT  O  N N 216 
LEU H    H  N N 217 
LEU H2   H  N N 218 
LEU HA   H  N N 219 
LEU HB2  H  N N 220 
LEU HB3  H  N N 221 
LEU HG   H  N N 222 
LEU HD11 H  N N 223 
LEU HD12 H  N N 224 
LEU HD13 H  N N 225 
LEU HD21 H  N N 226 
LEU HD22 H  N N 227 
LEU HD23 H  N N 228 
LEU HXT  H  N N 229 
LYS N    N  N N 230 
LYS CA   C  N S 231 
LYS C    C  N N 232 
LYS O    O  N N 233 
LYS CB   C  N N 234 
LYS CG   C  N N 235 
LYS CD   C  N N 236 
LYS CE   C  N N 237 
LYS NZ   N  N N 238 
LYS OXT  O  N N 239 
LYS H    H  N N 240 
LYS H2   H  N N 241 
LYS HA   H  N N 242 
LYS HB2  H  N N 243 
LYS HB3  H  N N 244 
LYS HG2  H  N N 245 
LYS HG3  H  N N 246 
LYS HD2  H  N N 247 
LYS HD3  H  N N 248 
LYS HE2  H  N N 249 
LYS HE3  H  N N 250 
LYS HZ1  H  N N 251 
LYS HZ2  H  N N 252 
LYS HZ3  H  N N 253 
LYS HXT  H  N N 254 
MET N    N  N N 255 
MET CA   C  N S 256 
MET C    C  N N 257 
MET O    O  N N 258 
MET CB   C  N N 259 
MET CG   C  N N 260 
MET SD   S  N N 261 
MET CE   C  N N 262 
MET OXT  O  N N 263 
MET H    H  N N 264 
MET H2   H  N N 265 
MET HA   H  N N 266 
MET HB2  H  N N 267 
MET HB3  H  N N 268 
MET HG2  H  N N 269 
MET HG3  H  N N 270 
MET HE1  H  N N 271 
MET HE2  H  N N 272 
MET HE3  H  N N 273 
MET HXT  H  N N 274 
PHE N    N  N N 275 
PHE CA   C  N S 276 
PHE C    C  N N 277 
PHE O    O  N N 278 
PHE CB   C  N N 279 
PHE CG   C  Y N 280 
PHE CD1  C  Y N 281 
PHE CD2  C  Y N 282 
PHE CE1  C  Y N 283 
PHE CE2  C  Y N 284 
PHE CZ   C  Y N 285 
PHE OXT  O  N N 286 
PHE H    H  N N 287 
PHE H2   H  N N 288 
PHE HA   H  N N 289 
PHE HB2  H  N N 290 
PHE HB3  H  N N 291 
PHE HD1  H  N N 292 
PHE HD2  H  N N 293 
PHE HE1  H  N N 294 
PHE HE2  H  N N 295 
PHE HZ   H  N N 296 
PHE HXT  H  N N 297 
PRO N    N  N N 298 
PRO CA   C  N S 299 
PRO C    C  N N 300 
PRO O    O  N N 301 
PRO CB   C  N N 302 
PRO CG   C  N N 303 
PRO CD   C  N N 304 
PRO OXT  O  N N 305 
PRO H    H  N N 306 
PRO HA   H  N N 307 
PRO HB2  H  N N 308 
PRO HB3  H  N N 309 
PRO HG2  H  N N 310 
PRO HG3  H  N N 311 
PRO HD2  H  N N 312 
PRO HD3  H  N N 313 
PRO HXT  H  N N 314 
SER N    N  N N 315 
SER CA   C  N S 316 
SER C    C  N N 317 
SER O    O  N N 318 
SER CB   C  N N 319 
SER OG   O  N N 320 
SER OXT  O  N N 321 
SER H    H  N N 322 
SER H2   H  N N 323 
SER HA   H  N N 324 
SER HB2  H  N N 325 
SER HB3  H  N N 326 
SER HG   H  N N 327 
SER HXT  H  N N 328 
SO4 S    S  N N 329 
SO4 O1   O  N N 330 
SO4 O2   O  N N 331 
SO4 O3   O  N N 332 
SO4 O4   O  N N 333 
THR N    N  N N 334 
THR CA   C  N S 335 
THR C    C  N N 336 
THR O    O  N N 337 
THR CB   C  N R 338 
THR OG1  O  N N 339 
THR CG2  C  N N 340 
THR OXT  O  N N 341 
THR H    H  N N 342 
THR H2   H  N N 343 
THR HA   H  N N 344 
THR HB   H  N N 345 
THR HG1  H  N N 346 
THR HG21 H  N N 347 
THR HG22 H  N N 348 
THR HG23 H  N N 349 
THR HXT  H  N N 350 
TRP N    N  N N 351 
TRP CA   C  N S 352 
TRP C    C  N N 353 
TRP O    O  N N 354 
TRP CB   C  N N 355 
TRP CG   C  Y N 356 
TRP CD1  C  Y N 357 
TRP CD2  C  Y N 358 
TRP NE1  N  Y N 359 
TRP CE2  C  Y N 360 
TRP CE3  C  Y N 361 
TRP CZ2  C  Y N 362 
TRP CZ3  C  Y N 363 
TRP CH2  C  Y N 364 
TRP OXT  O  N N 365 
TRP H    H  N N 366 
TRP H2   H  N N 367 
TRP HA   H  N N 368 
TRP HB2  H  N N 369 
TRP HB3  H  N N 370 
TRP HD1  H  N N 371 
TRP HE1  H  N N 372 
TRP HE3  H  N N 373 
TRP HZ2  H  N N 374 
TRP HZ3  H  N N 375 
TRP HH2  H  N N 376 
TRP HXT  H  N N 377 
TYR N    N  N N 378 
TYR CA   C  N S 379 
TYR C    C  N N 380 
TYR O    O  N N 381 
TYR CB   C  N N 382 
TYR CG   C  Y N 383 
TYR CD1  C  Y N 384 
TYR CD2  C  Y N 385 
TYR CE1  C  Y N 386 
TYR CE2  C  Y N 387 
TYR CZ   C  Y N 388 
TYR OH   O  N N 389 
TYR OXT  O  N N 390 
TYR H    H  N N 391 
TYR H2   H  N N 392 
TYR HA   H  N N 393 
TYR HB2  H  N N 394 
TYR HB3  H  N N 395 
TYR HD1  H  N N 396 
TYR HD2  H  N N 397 
TYR HE1  H  N N 398 
TYR HE2  H  N N 399 
TYR HH   H  N N 400 
TYR HXT  H  N N 401 
VAL N    N  N N 402 
VAL CA   C  N S 403 
VAL C    C  N N 404 
VAL O    O  N N 405 
VAL CB   C  N N 406 
VAL CG1  C  N N 407 
VAL CG2  C  N N 408 
VAL OXT  O  N N 409 
VAL H    H  N N 410 
VAL H2   H  N N 411 
VAL HA   H  N N 412 
VAL HB   H  N N 413 
VAL HG11 H  N N 414 
VAL HG12 H  N N 415 
VAL HG13 H  N N 416 
VAL HG21 H  N N 417 
VAL HG22 H  N N 418 
VAL HG23 H  N N 419 
VAL HXT  H  N N 420 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
GOL C1  O1   sing N N 138 
GOL C1  C2   sing N N 139 
GOL C1  H11  sing N N 140 
GOL C1  H12  sing N N 141 
GOL O1  HO1  sing N N 142 
GOL C2  O2   sing N N 143 
GOL C2  C3   sing N N 144 
GOL C2  H2   sing N N 145 
GOL O2  HO2  sing N N 146 
GOL C3  O3   sing N N 147 
GOL C3  H31  sing N N 148 
GOL C3  H32  sing N N 149 
GOL O3  HO3  sing N N 150 
HIS N   CA   sing N N 151 
HIS N   H    sing N N 152 
HIS N   H2   sing N N 153 
HIS CA  C    sing N N 154 
HIS CA  CB   sing N N 155 
HIS CA  HA   sing N N 156 
HIS C   O    doub N N 157 
HIS C   OXT  sing N N 158 
HIS CB  CG   sing N N 159 
HIS CB  HB2  sing N N 160 
HIS CB  HB3  sing N N 161 
HIS CG  ND1  sing Y N 162 
HIS CG  CD2  doub Y N 163 
HIS ND1 CE1  doub Y N 164 
HIS ND1 HD1  sing N N 165 
HIS CD2 NE2  sing Y N 166 
HIS CD2 HD2  sing N N 167 
HIS CE1 NE2  sing Y N 168 
HIS CE1 HE1  sing N N 169 
HIS NE2 HE2  sing N N 170 
HIS OXT HXT  sing N N 171 
HOH O   H1   sing N N 172 
HOH O   H2   sing N N 173 
ILE N   CA   sing N N 174 
ILE N   H    sing N N 175 
ILE N   H2   sing N N 176 
ILE CA  C    sing N N 177 
ILE CA  CB   sing N N 178 
ILE CA  HA   sing N N 179 
ILE C   O    doub N N 180 
ILE C   OXT  sing N N 181 
ILE CB  CG1  sing N N 182 
ILE CB  CG2  sing N N 183 
ILE CB  HB   sing N N 184 
ILE CG1 CD1  sing N N 185 
ILE CG1 HG12 sing N N 186 
ILE CG1 HG13 sing N N 187 
ILE CG2 HG21 sing N N 188 
ILE CG2 HG22 sing N N 189 
ILE CG2 HG23 sing N N 190 
ILE CD1 HD11 sing N N 191 
ILE CD1 HD12 sing N N 192 
ILE CD1 HD13 sing N N 193 
ILE OXT HXT  sing N N 194 
LEU N   CA   sing N N 195 
LEU N   H    sing N N 196 
LEU N   H2   sing N N 197 
LEU CA  C    sing N N 198 
LEU CA  CB   sing N N 199 
LEU CA  HA   sing N N 200 
LEU C   O    doub N N 201 
LEU C   OXT  sing N N 202 
LEU CB  CG   sing N N 203 
LEU CB  HB2  sing N N 204 
LEU CB  HB3  sing N N 205 
LEU CG  CD1  sing N N 206 
LEU CG  CD2  sing N N 207 
LEU CG  HG   sing N N 208 
LEU CD1 HD11 sing N N 209 
LEU CD1 HD12 sing N N 210 
LEU CD1 HD13 sing N N 211 
LEU CD2 HD21 sing N N 212 
LEU CD2 HD22 sing N N 213 
LEU CD2 HD23 sing N N 214 
LEU OXT HXT  sing N N 215 
LYS N   CA   sing N N 216 
LYS N   H    sing N N 217 
LYS N   H2   sing N N 218 
LYS CA  C    sing N N 219 
LYS CA  CB   sing N N 220 
LYS CA  HA   sing N N 221 
LYS C   O    doub N N 222 
LYS C   OXT  sing N N 223 
LYS CB  CG   sing N N 224 
LYS CB  HB2  sing N N 225 
LYS CB  HB3  sing N N 226 
LYS CG  CD   sing N N 227 
LYS CG  HG2  sing N N 228 
LYS CG  HG3  sing N N 229 
LYS CD  CE   sing N N 230 
LYS CD  HD2  sing N N 231 
LYS CD  HD3  sing N N 232 
LYS CE  NZ   sing N N 233 
LYS CE  HE2  sing N N 234 
LYS CE  HE3  sing N N 235 
LYS NZ  HZ1  sing N N 236 
LYS NZ  HZ2  sing N N 237 
LYS NZ  HZ3  sing N N 238 
LYS OXT HXT  sing N N 239 
MET N   CA   sing N N 240 
MET N   H    sing N N 241 
MET N   H2   sing N N 242 
MET CA  C    sing N N 243 
MET CA  CB   sing N N 244 
MET CA  HA   sing N N 245 
MET C   O    doub N N 246 
MET C   OXT  sing N N 247 
MET CB  CG   sing N N 248 
MET CB  HB2  sing N N 249 
MET CB  HB3  sing N N 250 
MET CG  SD   sing N N 251 
MET CG  HG2  sing N N 252 
MET CG  HG3  sing N N 253 
MET SD  CE   sing N N 254 
MET CE  HE1  sing N N 255 
MET CE  HE2  sing N N 256 
MET CE  HE3  sing N N 257 
MET OXT HXT  sing N N 258 
PHE N   CA   sing N N 259 
PHE N   H    sing N N 260 
PHE N   H2   sing N N 261 
PHE CA  C    sing N N 262 
PHE CA  CB   sing N N 263 
PHE CA  HA   sing N N 264 
PHE C   O    doub N N 265 
PHE C   OXT  sing N N 266 
PHE CB  CG   sing N N 267 
PHE CB  HB2  sing N N 268 
PHE CB  HB3  sing N N 269 
PHE CG  CD1  doub Y N 270 
PHE CG  CD2  sing Y N 271 
PHE CD1 CE1  sing Y N 272 
PHE CD1 HD1  sing N N 273 
PHE CD2 CE2  doub Y N 274 
PHE CD2 HD2  sing N N 275 
PHE CE1 CZ   doub Y N 276 
PHE CE1 HE1  sing N N 277 
PHE CE2 CZ   sing Y N 278 
PHE CE2 HE2  sing N N 279 
PHE CZ  HZ   sing N N 280 
PHE OXT HXT  sing N N 281 
PRO N   CA   sing N N 282 
PRO N   CD   sing N N 283 
PRO N   H    sing N N 284 
PRO CA  C    sing N N 285 
PRO CA  CB   sing N N 286 
PRO CA  HA   sing N N 287 
PRO C   O    doub N N 288 
PRO C   OXT  sing N N 289 
PRO CB  CG   sing N N 290 
PRO CB  HB2  sing N N 291 
PRO CB  HB3  sing N N 292 
PRO CG  CD   sing N N 293 
PRO CG  HG2  sing N N 294 
PRO CG  HG3  sing N N 295 
PRO CD  HD2  sing N N 296 
PRO CD  HD3  sing N N 297 
PRO OXT HXT  sing N N 298 
SER N   CA   sing N N 299 
SER N   H    sing N N 300 
SER N   H2   sing N N 301 
SER CA  C    sing N N 302 
SER CA  CB   sing N N 303 
SER CA  HA   sing N N 304 
SER C   O    doub N N 305 
SER C   OXT  sing N N 306 
SER CB  OG   sing N N 307 
SER CB  HB2  sing N N 308 
SER CB  HB3  sing N N 309 
SER OG  HG   sing N N 310 
SER OXT HXT  sing N N 311 
SO4 S   O1   doub N N 312 
SO4 S   O2   doub N N 313 
SO4 S   O3   sing N N 314 
SO4 S   O4   sing N N 315 
THR N   CA   sing N N 316 
THR N   H    sing N N 317 
THR N   H2   sing N N 318 
THR CA  C    sing N N 319 
THR CA  CB   sing N N 320 
THR CA  HA   sing N N 321 
THR C   O    doub N N 322 
THR C   OXT  sing N N 323 
THR CB  OG1  sing N N 324 
THR CB  CG2  sing N N 325 
THR CB  HB   sing N N 326 
THR OG1 HG1  sing N N 327 
THR CG2 HG21 sing N N 328 
THR CG2 HG22 sing N N 329 
THR CG2 HG23 sing N N 330 
THR OXT HXT  sing N N 331 
TRP N   CA   sing N N 332 
TRP N   H    sing N N 333 
TRP N   H2   sing N N 334 
TRP CA  C    sing N N 335 
TRP CA  CB   sing N N 336 
TRP CA  HA   sing N N 337 
TRP C   O    doub N N 338 
TRP C   OXT  sing N N 339 
TRP CB  CG   sing N N 340 
TRP CB  HB2  sing N N 341 
TRP CB  HB3  sing N N 342 
TRP CG  CD1  doub Y N 343 
TRP CG  CD2  sing Y N 344 
TRP CD1 NE1  sing Y N 345 
TRP CD1 HD1  sing N N 346 
TRP CD2 CE2  doub Y N 347 
TRP CD2 CE3  sing Y N 348 
TRP NE1 CE2  sing Y N 349 
TRP NE1 HE1  sing N N 350 
TRP CE2 CZ2  sing Y N 351 
TRP CE3 CZ3  doub Y N 352 
TRP CE3 HE3  sing N N 353 
TRP CZ2 CH2  doub Y N 354 
TRP CZ2 HZ2  sing N N 355 
TRP CZ3 CH2  sing Y N 356 
TRP CZ3 HZ3  sing N N 357 
TRP CH2 HH2  sing N N 358 
TRP OXT HXT  sing N N 359 
TYR N   CA   sing N N 360 
TYR N   H    sing N N 361 
TYR N   H2   sing N N 362 
TYR CA  C    sing N N 363 
TYR CA  CB   sing N N 364 
TYR CA  HA   sing N N 365 
TYR C   O    doub N N 366 
TYR C   OXT  sing N N 367 
TYR CB  CG   sing N N 368 
TYR CB  HB2  sing N N 369 
TYR CB  HB3  sing N N 370 
TYR CG  CD1  doub Y N 371 
TYR CG  CD2  sing Y N 372 
TYR CD1 CE1  sing Y N 373 
TYR CD1 HD1  sing N N 374 
TYR CD2 CE2  doub Y N 375 
TYR CD2 HD2  sing N N 376 
TYR CE1 CZ   doub Y N 377 
TYR CE1 HE1  sing N N 378 
TYR CE2 CZ   sing Y N 379 
TYR CE2 HE2  sing N N 380 
TYR CZ  OH   sing N N 381 
TYR OH  HH   sing N N 382 
TYR OXT HXT  sing N N 383 
VAL N   CA   sing N N 384 
VAL N   H    sing N N 385 
VAL N   H2   sing N N 386 
VAL CA  C    sing N N 387 
VAL CA  CB   sing N N 388 
VAL CA  HA   sing N N 389 
VAL C   O    doub N N 390 
VAL C   OXT  sing N N 391 
VAL CB  CG1  sing N N 392 
VAL CB  CG2  sing N N 393 
VAL CB  HB   sing N N 394 
VAL CG1 HG11 sing N N 395 
VAL CG1 HG12 sing N N 396 
VAL CG1 HG13 sing N N 397 
VAL CG2 HG21 sing N N 398 
VAL CG2 HG22 sing N N 399 
VAL CG2 HG23 sing N N 400 
VAL OXT HXT  sing N N 401 
# 
_pdbx_audit_support.funding_organization   'Novo Nordisk Foundation' 
_pdbx_audit_support.country                Denmark 
_pdbx_audit_support.grant_number           NNF20OC0064747 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Z5Y 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8S6S 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021614 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013674 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008590 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
CU 29 29 13.3445 3.5828  7.1711 0.2470  5.6185 11.3966 1.6743 64.8126 1.1090   
H  1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0487   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N   . HIS A 1 1   ? 24.395  -7.430  0.904   1.000 26.508  0 24  HIS A N   1 ? 
ATOM   2    C  CA  . HIS A 1 1   ? 25.528  -7.913  0.082   1.000 24.772  0 24  HIS A CA  1 ? 
ATOM   3    C  C   . HIS A 1 1   ? 25.241  -9.353  -0.366  1.000 25.604  0 24  HIS A C   1 ? 
ATOM   4    O  O   . HIS A 1 1   ? 24.651  -10.125 0.393   1.000 24.321  0 24  HIS A O   1 ? 
ATOM   5    C  CB  . HIS A 1 1   ? 26.846  -7.825  0.859   1.000 27.094  0 24  HIS A CB  1 ? 
ATOM   6    C  CG  . HIS A 1 1   ? 27.446  -6.485  0.721   1.000 28.442  0 24  HIS A CG  1 ? 
ATOM   7    N  ND1 . HIS A 1 1   ? 26.742  -5.380  1.151   1.000 29.390  0 24  HIS A ND1 1 ? 
ATOM   8    C  CD2 . HIS A 1 1   ? 28.581  -6.013  0.160   1.000 33.283  0 24  HIS A CD2 1 ? 
ATOM   9    C  CE1 . HIS A 1 1   ? 27.429  -4.278  0.874   1.000 31.154  0 24  HIS A CE1 1 ? 
ATOM   10   N  NE2 . HIS A 1 1   ? 28.558  -4.641  0.272   1.000 34.262  0 24  HIS A NE2 1 ? 
ATOM   11   N  N   . GLY A 1 2   ? 25.657  -9.699  -1.593  1.000 21.532  0 25  GLY A N   1 ? 
ATOM   12   C  CA  . GLY A 1 2   ? 25.560  -11.066 -2.088  1.000 22.133  0 25  GLY A CA  1 ? 
ATOM   13   C  C   . GLY A 1 2   ? 24.988  -11.131 -3.508  1.000 23.040  0 25  GLY A C   1 ? 
ATOM   14   O  O   . GLY A 1 2   ? 24.489  -10.131 -4.036  1.000 23.293  0 25  GLY A O   1 ? 
ATOM   15   N  N   . TYR A 1 3   ? 25.103  -12.316 -4.108  1.000 20.119  0 26  TYR A N   1 ? 
ATOM   16   C  CA  . TYR A 1 3   ? 24.631  -12.574 -5.457  1.000 19.965  0 26  TYR A CA  1 ? 
ATOM   17   C  C   . TYR A 1 3   ? 24.193  -14.029 -5.520  1.000 21.598  0 26  TYR A C   1 ? 
ATOM   18   O  O   . TYR A 1 3   ? 24.566  -14.821 -4.665  1.000 21.394  0 26  TYR A O   1 ? 
ATOM   19   C  CB  . TYR A 1 3   ? 25.666  -12.232 -6.531  1.000 20.679  0 26  TYR A CB  1 ? 
ATOM   20   C  CG  . TYR A 1 3   ? 26.978  -12.991 -6.385  1.000 21.104  0 26  TYR A CG  1 ? 
ATOM   21   C  CD1 . TYR A 1 3   ? 27.109  -14.283 -6.864  1.000 22.247  0 26  TYR A CD1 1 ? 
ATOM   22   C  CD2 . TYR A 1 3   ? 28.032  -12.461 -5.655  1.000 22.190  0 26  TYR A CD2 1 ? 
ATOM   23   C  CE1 . TYR A 1 3   ? 28.280  -15.003 -6.680  1.000 23.167  0 26  TYR A CE1 1 ? 
ATOM   24   C  CE2 . TYR A 1 3   ? 29.210  -13.157 -5.471  1.000 26.111  0 26  TYR A CE2 1 ? 
ATOM   25   C  CZ  . TYR A 1 3   ? 29.328  -14.424 -5.993  1.000 23.041  0 26  TYR A CZ  1 ? 
ATOM   26   O  OH  . TYR A 1 3   ? 30.495  -15.076 -5.805  1.000 27.853  0 26  TYR A OH  1 ? 
ATOM   27   N  N   . ILE A 1 4   ? 23.365  -14.355 -6.507  1.000 21.460  0 27  ILE A N   1 ? 
ATOM   28   C  CA  . ILE A 1 4   ? 22.991  -15.731 -6.761  1.000 20.484  0 27  ILE A CA  1 ? 
ATOM   29   C  C   . ILE A 1 4   ? 24.257  -16.424 -7.258  1.000 21.729  0 27  ILE A C   1 ? 
ATOM   30   O  O   . ILE A 1 4   ? 24.800  -16.020 -8.270  1.000 21.140  0 27  ILE A O   1 ? 
ATOM   31   C  CB  . ILE A 1 4   ? 21.880  -15.815 -7.820  1.000 22.998  0 27  ILE A CB  1 ? 
ATOM   32   C  CG1 . ILE A 1 4   ? 20.597  -15.150 -7.342  1.000 27.422  0 27  ILE A CG1 1 ? 
ATOM   33   C  CG2 . ILE A 1 4   ? 21.601  -17.254 -8.228  1.000 22.147  0 27  ILE A CG2 1 ? 
ATOM   34   C  CD1 . ILE A 1 4   ? 19.936  -15.861 -6.265  1.000 27.619  0 27  ILE A CD1 1 ? 
ATOM   35   N  N   . ALA A 1 5   ? 24.673  -17.468 -6.560  1.000 20.219  0 28  ALA A N   1 ? 
ATOM   36   C  CA  . ALA A 1 5   ? 25.884  -18.217 -6.859  1.000 23.538  0 28  ALA A CA  1 ? 
ATOM   37   C  C   . ALA A 1 5   ? 25.591  -19.519 -7.586  1.000 23.059  0 28  ALA A C   1 ? 
ATOM   38   O  O   . ALA A 1 5   ? 26.470  -20.046 -8.269  1.000 25.339  0 28  ALA A O   1 ? 
ATOM   39   C  CB  . ALA A 1 5   ? 26.605  -18.519 -5.554  1.000 24.921  0 28  ALA A CB  1 ? 
ATOM   40   N  N   . LYS A 1 6   ? 24.392  -20.077 -7.391  1.000 23.475  0 29  LYS A N   1 ? 
ATOM   41   C  CA  . LYS A 1 6   ? 23.941  -21.241 -8.157  1.000 26.244  0 29  LYS A CA  1 ? 
ATOM   42   C  C   . LYS A 1 6   ? 22.508  -21.010 -8.565  1.000 26.319  0 29  LYS A C   1 ? 
ATOM   43   O  O   . LYS A 1 6   ? 21.635  -20.811 -7.715  1.000 25.580  0 29  LYS A O   1 ? 
ATOM   44   C  CB  . LYS A 1 6   ? 24.037  -22.564 -7.389  1.000 30.296  0 29  LYS A CB  1 ? 
ATOM   45   C  CG  . LYS A 1 6   ? 25.443  -22.923 -6.945  1.000 39.515  0 29  LYS A CG  1 ? 
ATOM   46   C  CD  . LYS A 1 6   ? 25.660  -24.418 -6.678  1.000 50.324  0 29  LYS A CD  1 ? 
ATOM   47   C  CE  . LYS A 1 6   ? 24.749  -24.982 -5.604  1.000 60.131  0 29  LYS A CE  1 ? 
ATOM   48   N  NZ  . LYS A 1 6   ? 25.135  -24.544 -4.240  1.000 65.738  0 29  LYS A NZ  1 ? 
ATOM   49   N  N   . PRO A 1 7   ? 22.216  -20.903 -9.881  1.000 21.805  0 30  PRO A N   1 ? 
ATOM   50   C  CA  . PRO A 1 7   ? 23.226  -21.082 -10.929 1.000 23.881  0 30  PRO A CA  1 ? 
ATOM   51   C  C   . PRO A 1 7   ? 24.287  -19.988 -10.977 1.000 26.000  0 30  PRO A C   1 ? 
ATOM   52   O  O   . PRO A 1 7   ? 24.101  -18.904 -10.418 1.000 25.172  0 30  PRO A O   1 ? 
ATOM   53   C  CB  . PRO A 1 7   ? 22.401  -21.026 -12.205 1.000 23.600  0 30  PRO A CB  1 ? 
ATOM   54   C  CG  . PRO A 1 7   ? 21.143  -20.253 -11.848 1.000 24.245  0 30  PRO A CG  1 ? 
ATOM   55   C  CD  . PRO A 1 7   ? 20.918  -20.434 -10.367 1.000 24.113  0 30  PRO A CD  1 ? 
ATOM   56   N  N   . GLU A 1 8   ? 25.392  -20.300 -11.686 1.000 27.370  0 31  GLU A N   1 ? 
ATOM   57   C  CA  . GLU A 1 8   ? 26.622  -19.522 -11.609 1.000 25.618  0 31  GLU A CA  1 ? 
ATOM   58   C  C   . GLU A 1 8   ? 26.568  -18.312 -12.528 1.000 24.213  0 31  GLU A C   1 ? 
ATOM   59   O  O   . GLU A 1 8   ? 26.471  -18.463 -13.755 1.000 24.734  0 31  GLU A O   1 ? 
ATOM   60   C  CB  . GLU A 1 8   ? 27.816  -20.396 -11.982 1.000 31.698  0 31  GLU A CB  1 ? 
ATOM   61   C  CG  . GLU A 1 8   ? 28.040  -21.544 -11.020 1.000 45.651  0 31  GLU A CG  1 ? 
ATOM   62   C  CD  . GLU A 1 8   ? 29.301  -22.353 -11.285 1.000 67.498  0 31  GLU A CD  1 ? 
ATOM   63   O  OE1 . GLU A 1 8   ? 30.365  -21.714 -11.567 1.000 64.809  0 31  GLU A OE1 1 ? 
ATOM   64   O  OE2 . GLU A 1 8   ? 29.224  -23.618 -11.187 1.000 73.083  0 31  GLU A OE2 1 ? 
ATOM   65   N  N   . PRO A 1 9   ? 26.728  -17.086 -12.000 1.000 24.108  0 32  PRO A N   1 ? 
ATOM   66   C  CA  . PRO A 1 9   ? 26.768  -15.895 -12.841 1.000 23.494  0 32  PRO A CA  1 ? 
ATOM   67   C  C   . PRO A 1 9   ? 28.132  -15.654 -13.487 1.000 24.349  0 32  PRO A C   1 ? 
ATOM   68   O  O   . PRO A 1 9   ? 29.153  -16.157 -13.025 1.000 24.871  0 32  PRO A O   1 ? 
ATOM   69   C  CB  . PRO A 1 9   ? 26.480  -14.777 -11.833 1.000 27.024  0 32  PRO A CB  1 ? 
ATOM   70   C  CG  . PRO A 1 9   ? 27.071  -15.285 -10.558 1.000 26.328  0 32  PRO A CG  1 ? 
ATOM   71   C  CD  . PRO A 1 9   ? 26.896  -16.774 -10.568 1.000 25.789  0 32  PRO A CD  1 ? 
ATOM   72   N  N   . SER A 1 10  ? 28.149  -14.879 -14.575 1.000 24.271  0 33  SER A N   1 ? 
ATOM   73   C  CA  . SER A 1 10  ? 29.359  -14.292 -15.135 1.000 23.099  0 33  SER A CA  1 ? 
ATOM   74   C  C   . SER A 1 10  ? 29.370  -12.795 -14.840 1.000 25.098  0 33  SER A C   1 ? 
ATOM   75   O  O   . SER A 1 10  ? 28.343  -12.225 -14.496 1.000 26.317  0 33  SER A O   1 ? 
ATOM   76   C  CB  . SER A 1 10  ? 29.423  -14.497 -16.642 1.000 27.949  0 33  SER A CB  1 ? 
ATOM   77   O  OG  . SER A 1 10  ? 29.264  -15.854 -17.026 1.000 25.719  0 33  SER A OG  1 ? 
ATOM   78   N  N   . TRP A 1 11  ? 30.541  -12.171 -14.943 1.000 26.365  0 34  TRP A N   1 ? 
ATOM   79   C  CA  . TRP A 1 11  ? 30.729  -10.797 -14.513 1.000 25.772  0 34  TRP A CA  1 ? 
ATOM   80   C  C   . TRP A 1 11  ? 31.237  -9.941  -15.666 1.000 30.673  0 34  TRP A C   1 ? 
ATOM   81   O  O   . TRP A 1 11  ? 32.035  -10.419 -16.463 1.000 29.323  0 34  TRP A O   1 ? 
ATOM   82   C  CB  . TRP A 1 11  ? 31.700  -10.801 -13.336 1.000 26.497  0 34  TRP A CB  1 ? 
ATOM   83   C  CG  . TRP A 1 11  ? 31.182  -11.663 -12.225 1.000 24.594  0 34  TRP A CG  1 ? 
ATOM   84   C  CD1 . TRP A 1 11  ? 31.436  -12.985 -11.986 1.000 28.331  0 34  TRP A CD1 1 ? 
ATOM   85   C  CD2 . TRP A 1 11  ? 30.211  -11.252 -11.253 1.000 25.201  0 34  TRP A CD2 1 ? 
ATOM   86   N  NE1 . TRP A 1 11  ? 30.711  -13.417 -10.904 1.000 29.774  0 34  TRP A NE1 1 ? 
ATOM   87   C  CE2 . TRP A 1 11  ? 29.945  -12.376 -10.439 1.000 27.926  0 34  TRP A CE2 1 ? 
ATOM   88   C  CE3 . TRP A 1 11  ? 29.561  -10.037 -10.983 1.000 26.274  0 34  TRP A CE3 1 ? 
ATOM   89   C  CZ2 . TRP A 1 11  ? 29.067  -12.314 -9.361  1.000 23.777  0 34  TRP A CZ2 1 ? 
ATOM   90   C  CZ3 . TRP A 1 11  ? 28.680  -9.985  -9.926  1.000 26.124  0 34  TRP A CZ3 1 ? 
ATOM   91   C  CH2 . TRP A 1 11  ? 28.413  -11.120 -9.157  1.000 25.794  0 34  TRP A CH2 1 ? 
ATOM   92   N  N   . LYS A 1 12  ? 30.728  -8.703  -15.756 1.000 29.542  0 35  LYS A N   1 ? 
ATOM   93   C  CA  . LYS A 1 12  ? 31.220  -7.716  -16.705 1.000 36.215  0 35  LYS A CA  1 ? 
ATOM   94   C  C   . LYS A 1 12  ? 32.717  -7.504  -16.494 1.000 37.910  0 35  LYS A C   1 ? 
ATOM   95   O  O   . LYS A 1 12  ? 33.451  -7.413  -17.466 1.000 40.839  0 35  LYS A O   1 ? 
ATOM   96   C  CB  . LYS A 1 12  ? 30.421  -6.420  -16.588 1.000 38.865  0 35  LYS A CB  1 ? 
ATOM   97   C  CG  . LYS A 1 12  ? 28.999  -6.533  -17.107 1.000 44.004  0 35  LYS A CG  1 ? 
ATOM   98   C  CD  . LYS A 1 12  ? 28.141  -5.272  -16.962 1.000 48.057  0 35  LYS A CD  1 ? 
ATOM   99   C  CE  . LYS A 1 12  ? 26.747  -5.488  -17.509 1.000 47.178  0 35  LYS A CE  1 ? 
ATOM   100  N  NZ  . LYS A 1 12  ? 25.698  -5.019  -16.573 1.000 44.812  0 35  LYS A NZ  1 ? 
ATOM   101  N  N   . ASP A 1 13  ? 33.164  -7.451  -15.240 1.000 34.617  0 36  ASP A N   1 ? 
ATOM   102  C  CA  . ASP A 1 13  ? 34.570  -7.321  -14.894 1.000 39.274  0 36  ASP A CA  1 ? 
ATOM   103  C  C   . ASP A 1 13  ? 34.952  -8.448  -13.935 1.000 41.917  0 36  ASP A C   1 ? 
ATOM   104  O  O   . ASP A 1 13  ? 35.371  -9.514  -14.383 1.000 39.900  0 36  ASP A O   1 ? 
ATOM   105  C  CB  . ASP A 1 13  ? 34.842  -5.924  -14.331 1.000 46.739  0 36  ASP A CB  1 ? 
ATOM   106  C  CG  . ASP A 1 13  ? 36.314  -5.609  -14.125 1.000 63.059  0 36  ASP A CG  1 ? 
ATOM   107  O  OD1 . ASP A 1 13  ? 37.167  -6.508  -14.362 1.000 63.553  0 36  ASP A OD1 1 ? 
ATOM   108  O  OD2 . ASP A 1 13  ? 36.601  -4.455  -13.743 1.000 79.656  0 36  ASP A OD2 1 ? 
ATOM   109  N  N   . LYS A 1 14  ? 34.758  -8.237  -12.617 1.000 38.898  0 37  LYS A N   1 ? 
ATOM   110  C  CA  . LYS A 1 14  ? 35.147  -9.204  -11.602 1.000 45.142  0 37  LYS A CA  1 ? 
ATOM   111  C  C   . LYS A 1 14  ? 33.973  -9.472  -10.659 1.000 34.450  0 37  LYS A C   1 ? 
ATOM   112  O  O   . LYS A 1 14  ? 33.114  -8.630  -10.505 1.000 31.101  0 37  LYS A O   1 ? 
ATOM   113  C  CB  . LYS A 1 14  ? 36.324  -8.644  -10.797 1.000 63.680  0 37  LYS A CB  1 ? 
ATOM   114  C  CG  . LYS A 1 14  ? 37.413  -9.654  -10.451 1.000 78.560  0 37  LYS A CG  1 ? 
ATOM   115  C  CD  . LYS A 1 14  ? 38.745  -9.004  -10.102 1.000 87.090  0 37  LYS A CD  1 ? 
ATOM   116  C  CE  . LYS A 1 14  ? 39.432  -8.379  -11.302 1.000 90.845  0 37  LYS A CE  1 ? 
ATOM   117  N  NZ  . LYS A 1 14  ? 40.643  -7.615  -10.915 1.000 90.388  0 37  LYS A NZ  1 ? 
ATOM   118  N  N   . LYS A 1 15  ? 33.964  -10.643 -10.045 1.000 34.266  0 38  LYS A N   1 ? 
ATOM   119  C  CA  . LYS A 1 15  ? 32.952  -11.048 -9.087  1.000 33.609  0 38  LYS A CA  1 ? 
ATOM   120  C  C   . LYS A 1 15  ? 32.856  -9.978  -7.997  1.000 35.950  0 38  LYS A C   1 ? 
ATOM   121  O  O   . LYS A 1 15  ? 33.870  -9.482  -7.532  1.000 30.554  0 38  LYS A O   1 ? 
ATOM   122  C  CB  . LYS A 1 15  ? 33.338  -12.427 -8.561  1.000 41.719  0 38  LYS A CB  1 ? 
ATOM   123  C  CG  . LYS A 1 15  ? 32.848  -12.770 -7.167  1.000 51.719  0 38  LYS A CG  1 ? 
ATOM   124  C  CD  . LYS A 1 15  ? 33.730  -13.777 -6.470  1.000 61.575  0 38  LYS A CD  1 ? 
ATOM   125  C  CE  . LYS A 1 15  ? 33.879  -15.067 -7.248  1.000 66.515  0 38  LYS A CE  1 ? 
ATOM   126  N  NZ  . LYS A 1 15  ? 34.745  -16.034 -6.526  1.000 72.339  0 38  LYS A NZ  1 ? 
ATOM   127  N  N   . THR A 1 16  ? 31.633  -9.570  -7.628  1.000 30.147  0 39  THR A N   1 ? 
ATOM   128  C  CA  . THR A 1 16  ? 31.464  -8.622  -6.544  1.000 26.953  0 39  THR A CA  1 ? 
ATOM   129  C  C   . THR A 1 16  ? 30.125  -8.880  -5.869  1.000 24.514  0 39  THR A C   1 ? 
ATOM   130  O  O   . THR A 1 16  ? 29.169  -9.208  -6.539  1.000 25.359  0 39  THR A O   1 ? 
ATOM   131  C  CB  . THR A 1 16  ? 31.522  -7.183  -7.046  1.000 30.138  0 39  THR A CB  1 ? 
ATOM   132  O  OG1 . THR A 1 16  ? 31.168  -6.299  -5.987  1.000 31.388  0 39  THR A OG1 1 ? 
ATOM   133  C  CG2 . THR A 1 16  ? 30.593  -6.925  -8.200  1.000 29.299  0 39  THR A CG2 1 ? 
ATOM   134  N  N   . ASN A 1 17  ? 30.088  -8.713  -4.559  1.000 24.500  0 40  ASN A N   1 ? 
ATOM   135  C  CA  . ASN A 1 17  ? 28.883  -8.867  -3.762  1.000 23.277  0 40  ASN A CA  1 ? 
ATOM   136  C  C   . ASN A 1 17  ? 28.131  -7.531  -3.634  1.000 23.270  0 40  ASN A C   1 ? 
ATOM   137  O  O   . ASN A 1 17  ? 27.124  -7.479  -2.931  1.000 24.050  0 40  ASN A O   1 ? 
ATOM   138  C  CB  . ASN A 1 17  ? 29.240  -9.435  -2.382  1.000 29.560  0 40  ASN A CB  1 ? 
ATOM   139  C  CG  . ASN A 1 17  ? 29.650  -10.892 -2.387  1.000 31.323  0 40  ASN A CG  1 ? 
ATOM   140  O  OD1 . ASN A 1 17  ? 30.835  -11.225 -2.385  1.000 40.628  0 40  ASN A OD1 1 ? 
ATOM   141  N  ND2 . ASN A 1 17  ? 28.684  -11.793 -2.350  1.000 30.461  0 40  ASN A ND2 1 ? 
ATOM   142  N  N   A ASP A 1 18  ? 28.645  -6.449  -4.230  0.500 22.646  0 41  ASP A N   1 ? 
ATOM   143  N  N   B ASP A 1 18  ? 28.604  -6.485  -4.318  0.500 23.801  0 41  ASP A N   1 ? 
ATOM   144  C  CA  A ASP A 1 18  ? 28.168  -5.110  -3.897  0.500 25.833  0 41  ASP A CA  1 ? 
ATOM   145  C  CA  B ASP A 1 18  ? 28.175  -5.125  -4.028  0.500 27.436  0 41  ASP A CA  1 ? 
ATOM   146  C  C   A ASP A 1 18  ? 26.827  -4.811  -4.566  0.500 23.878  0 41  ASP A C   1 ? 
ATOM   147  C  C   B ASP A 1 18  ? 26.803  -4.805  -4.615  0.500 24.650  0 41  ASP A C   1 ? 
ATOM   148  O  O   A ASP A 1 18  ? 26.423  -5.400  -5.569  0.500 24.641  0 41  ASP A O   1 ? 
ATOM   149  O  O   B ASP A 1 18  ? 26.355  -5.369  -5.617  0.500 25.075  0 41  ASP A O   1 ? 
ATOM   150  C  CB  A ASP A 1 18  ? 29.180  -4.028  -4.299  0.500 27.810  0 41  ASP A CB  1 ? 
ATOM   151  C  CB  B ASP A 1 18  ? 29.198  -4.099  -4.528  0.500 30.970  0 41  ASP A CB  1 ? 
ATOM   152  C  CG  A ASP A 1 18  ? 29.334  -2.824  -3.369  0.500 29.954  0 41  ASP A CG  1 ? 
ATOM   153  C  CG  B ASP A 1 18  ? 30.423  -3.972  -3.629  0.500 33.615  0 41  ASP A CG  1 ? 
ATOM   154  O  OD1 A ASP A 1 18  ? 28.535  -2.665  -2.428  0.500 24.565  0 41  ASP A OD1 1 ? 
ATOM   155  O  OD1 B ASP A 1 18  ? 30.390  -4.536  -2.523  0.500 37.748  0 41  ASP A OD1 1 ? 
ATOM   156  O  OD2 A ASP A 1 18  ? 30.293  -2.039  -3.599  0.500 34.743  0 41  ASP A OD2 1 ? 
ATOM   157  O  OD2 B ASP A 1 18  ? 31.397  -3.300  -4.044  0.500 38.048  0 41  ASP A OD2 1 ? 
ATOM   158  N  N   . TRP A 1 19  ? 26.163  -3.810  -3.991  1.000 25.250  0 42  TRP A N   1 ? 
ATOM   159  C  CA  . TRP A 1 19  ? 24.948  -3.239  -4.521  1.000 24.033  0 42  TRP A CA  1 ? 
ATOM   160  C  C   . TRP A 1 19  ? 25.214  -2.423  -5.774  1.000 23.548  0 42  TRP A C   1 ? 
ATOM   161  O  O   . TRP A 1 19  ? 26.331  -1.927  -5.979  1.000 24.574  0 42  TRP A O   1 ? 
ATOM   162  C  CB  . TRP A 1 19  ? 24.250  -2.388  -3.447  1.000 22.843  0 42  TRP A CB  1 ? 
ATOM   163  C  CG  . TRP A 1 19  ? 25.124  -1.547  -2.562  1.000 23.796  0 42  TRP A CG  1 ? 
ATOM   164  C  CD1 . TRP A 1 19  ? 25.487  -1.815  -1.289  1.000 22.911  0 42  TRP A CD1 1 ? 
ATOM   165  C  CD2 . TRP A 1 19  ? 25.668  -0.247  -2.875  1.000 23.671  0 42  TRP A CD2 1 ? 
ATOM   166  N  NE1 . TRP A 1 19  ? 26.255  -0.793  -0.797  1.000 26.450  0 42  TRP A NE1 1 ? 
ATOM   167  C  CE2 . TRP A 1 19  ? 26.380  0.179   -1.740  1.000 25.229  0 42  TRP A CE2 1 ? 
ATOM   168  C  CE3 . TRP A 1 19  ? 25.637  0.552   -4.012  1.000 25.546  0 42  TRP A CE3 1 ? 
ATOM   169  C  CZ2 . TRP A 1 19  ? 27.047  1.401   -1.705  1.000 26.694  0 42  TRP A CZ2 1 ? 
ATOM   170  C  CZ3 . TRP A 1 19  ? 26.284  1.774   -3.985  1.000 27.891  0 42  TRP A CZ3 1 ? 
ATOM   171  C  CH2 . TRP A 1 19  ? 26.957  2.183   -2.829  1.000 25.680  0 42  TRP A CH2 1 ? 
ATOM   172  N  N   . VAL A 1 20  ? 24.184  -2.325  -6.599  1.000 19.519  0 43  VAL A N   1 ? 
ATOM   173  C  CA  . VAL A 1 20  ? 24.225  -1.572  -7.832  1.000 22.541  0 43  VAL A CA  1 ? 
ATOM   174  C  C   . VAL A 1 20  ? 24.125  -0.078  -7.520  1.000 25.957  0 43  VAL A C   1 ? 
ATOM   175  O  O   . VAL A 1 20  ? 24.932  0.717   -8.014  1.000 24.645  0 43  VAL A O   1 ? 
ATOM   176  C  CB  . VAL A 1 20  ? 23.145  -2.000  -8.825  1.000 23.634  0 43  VAL A CB  1 ? 
ATOM   177  C  CG1 . VAL A 1 20  ? 23.235  -1.196  -10.100 1.000 27.869  0 43  VAL A CG1 1 ? 
ATOM   178  C  CG2 . VAL A 1 20  ? 23.188  -3.492  -9.133  1.000 25.644  0 43  VAL A CG2 1 ? 
ATOM   179  N  N   . VAL A 1 21  ? 23.132  0.296   -6.698  1.000 24.434  0 44  VAL A N   1 ? 
ATOM   180  C  CA  . VAL A 1 21  ? 23.023  1.666   -6.198  1.000 25.303  0 44  VAL A CA  1 ? 
ATOM   181  C  C   . VAL A 1 21  ? 22.622  1.665   -4.728  1.000 24.183  0 44  VAL A C   1 ? 
ATOM   182  O  O   . VAL A 1 21  ? 22.060  0.691   -4.255  1.000 21.984  0 44  VAL A O   1 ? 
ATOM   183  C  CB  . VAL A 1 21  ? 22.019  2.480   -7.014  1.000 24.192  0 44  VAL A CB  1 ? 
ATOM   184  C  CG1 . VAL A 1 21  ? 22.464  2.649   -8.450  1.000 28.745  0 44  VAL A CG1 1 ? 
ATOM   185  C  CG2 . VAL A 1 21  ? 20.589  1.972   -6.907  1.000 23.869  0 44  VAL A CG2 1 ? 
ATOM   186  N  N   . GLU A 1 22  ? 22.903  2.777   -4.035  1.000 22.253  0 45  GLU A N   1 ? 
ATOM   187  C  CA  . GLU A 1 22  ? 22.396  3.045   -2.709  1.000 20.992  0 45  GLU A CA  1 ? 
ATOM   188  C  C   . GLU A 1 22  ? 21.809  4.438   -2.741  1.000 23.443  0 45  GLU A C   1 ? 
ATOM   189  O  O   . GLU A 1 22  ? 22.517  5.362   -3.159  1.000 22.133  0 45  GLU A O   1 ? 
ATOM   190  C  CB  . GLU A 1 22  ? 23.505  3.042   -1.694  1.000 22.901  0 45  GLU A CB  1 ? 
ATOM   191  C  CG  . GLU A 1 22  ? 23.069  3.359   -0.308  1.000 23.958  0 45  GLU A CG  1 ? 
ATOM   192  C  CD  . GLU A 1 22  ? 24.260  3.300   0.622   1.000 32.689  0 45  GLU A CD  1 ? 
ATOM   193  O  OE1 . GLU A 1 22  ? 24.590  2.173   1.061   1.000 30.645  0 45  GLU A OE1 1 ? 
ATOM   194  O  OE2 . GLU A 1 22  ? 24.892  4.375   0.858   1.000 35.712  0 45  GLU A OE2 1 ? 
ATOM   195  N  N   . ILE A 1 23  ? 20.525  4.536   -2.416  1.000 20.507  0 46  ILE A N   1 ? 
ATOM   196  C  CA  . ILE A 1 23  ? 19.773  5.761   -2.635  1.000 21.141  0 46  ILE A CA  1 ? 
ATOM   197  C  C   . ILE A 1 23  ? 18.928  6.065   -1.409  1.000 22.004  0 46  ILE A C   1 ? 
ATOM   198  O  O   . ILE A 1 23  ? 18.672  5.213   -0.568  1.000 20.345  0 46  ILE A O   1 ? 
ATOM   199  C  CB  . ILE A 1 23  ? 18.896  5.658   -3.904  1.000 22.089  0 46  ILE A CB  1 ? 
ATOM   200  C  CG1 . ILE A 1 23  ? 17.892  4.499   -3.790  1.000 21.531  0 46  ILE A CG1 1 ? 
ATOM   201  C  CG2 . ILE A 1 23  ? 19.749  5.580   -5.187  1.000 25.219  0 46  ILE A CG2 1 ? 
ATOM   202  C  CD1 . ILE A 1 23  ? 17.097  4.297   -5.013  1.000 22.989  0 46  ILE A CD1 1 ? 
ATOM   203  N  N   . GLU A 1 24  ? 18.448  7.315   -1.324  1.000 22.659  0 47  GLU A N   1 ? 
ATOM   204  C  CA  . GLU A 1 24  ? 17.492  7.593   -0.278  1.000 22.897  0 47  GLU A CA  1 ? 
ATOM   205  C  C   . GLU A 1 24  ? 16.190  6.858   -0.615  1.000 18.331  0 47  GLU A C   1 ? 
ATOM   206  O  O   . GLU A 1 24  ? 15.900  6.473   -1.742  1.000 19.036  0 47  GLU A O   1 ? 
ATOM   207  C  CB  . GLU A 1 24  ? 17.261  9.093   -0.083  1.000 24.808  0 47  GLU A CB  1 ? 
ATOM   208  C  CG  . GLU A 1 24  ? 16.469  9.748   -1.146  1.000 28.632  0 47  GLU A CG  1 ? 
ATOM   209  C  CD  . GLU A 1 24  ? 16.443  11.254  -0.867  1.000 35.434  0 47  GLU A CD  1 ? 
ATOM   210  O  OE1 . GLU A 1 24  ? 17.156  12.003  -1.565  1.000 36.401  0 47  GLU A OE1 1 ? 
ATOM   211  O  OE2 . GLU A 1 24  ? 15.746  11.666  0.083   1.000 37.566  0 47  GLU A OE2 1 ? 
ATOM   212  N  N   . PRO A 1 25  ? 15.361  6.571   0.390   1.000 18.422  0 48  PRO A N   1 ? 
ATOM   213  C  CA  . PRO A 1 25  ? 14.079  5.913   0.125   1.000 19.766  0 48  PRO A CA  1 ? 
ATOM   214  C  C   . PRO A 1 25  ? 13.304  6.756   -0.875  1.000 21.696  0 48  PRO A C   1 ? 
ATOM   215  O  O   . PRO A 1 25  ? 13.286  7.995   -0.747  1.000 22.282  0 48  PRO A O   1 ? 
ATOM   216  C  CB  . PRO A 1 25  ? 13.382  5.938   1.501   1.000 20.417  0 48  PRO A CB  1 ? 
ATOM   217  C  CG  . PRO A 1 25  ? 14.514  5.955   2.485   1.000 21.816  0 48  PRO A CG  1 ? 
ATOM   218  C  CD  . PRO A 1 25  ? 15.635  6.762   1.823   1.000 22.001  0 48  PRO A CD  1 ? 
ATOM   219  N  N   . GLN A 1 26  ? 12.725  6.102   -1.875  1.000 20.459  0 49  GLN A N   1 ? 
ATOM   220  C  CA  . GLN A 1 26  ? 12.133  6.824   -2.991  1.000 20.513  0 49  GLN A CA  1 ? 
ATOM   221  C  C   . GLN A 1 26  ? 10.704  7.236   -2.677  1.000 23.323  0 49  GLN A C   1 ? 
ATOM   222  O  O   . GLN A 1 26  ? 10.092  7.967   -3.450  1.000 23.171  0 49  GLN A O   1 ? 
ATOM   223  C  CB  . GLN A 1 26  ? 12.189  6.000   -4.282  1.000 20.592  0 49  GLN A CB  1 ? 
ATOM   224  C  CG  . GLN A 1 26  ? 13.603  5.768   -4.739  1.000 19.492  0 49  GLN A CG  1 ? 
ATOM   225  C  CD  . GLN A 1 26  ? 14.230  7.093   -5.133  1.000 20.856  0 49  GLN A CD  1 ? 
ATOM   226  O  OE1 . GLN A 1 26  ? 13.848  7.745   -6.117  1.000 24.227  0 49  GLN A OE1 1 ? 
ATOM   227  N  NE2 . GLN A 1 26  ? 15.154  7.547   -4.314  1.000 21.544  0 49  GLN A NE2 1 ? 
ATOM   228  N  N   . TRP A 1 27  ? 10.194  6.763   -1.536  1.000 23.066  0 50  TRP A N   1 ? 
ATOM   229  C  CA  . TRP A 1 27  ? 8.901   7.171   -0.993  1.000 24.093  0 50  TRP A CA  1 ? 
ATOM   230  C  C   . TRP A 1 27  ? 9.135   7.900   0.326   1.000 24.790  0 50  TRP A C   1 ? 
ATOM   231  O  O   . TRP A 1 27  ? 9.791   7.381   1.238   1.000 24.269  0 50  TRP A O   1 ? 
ATOM   232  C  CB  . TRP A 1 27  ? 7.983   5.957   -0.794  1.000 24.570  0 50  TRP A CB  1 ? 
ATOM   233  C  CG  . TRP A 1 27  ? 7.870   5.042   -1.987  1.000 23.641  0 50  TRP A CG  1 ? 
ATOM   234  C  CD1 . TRP A 1 27  ? 7.873   5.375   -3.305  1.000 23.864  0 50  TRP A CD1 1 ? 
ATOM   235  C  CD2 . TRP A 1 27  ? 7.680   3.607   -1.942  1.000 21.715  0 50  TRP A CD2 1 ? 
ATOM   236  N  NE1 . TRP A 1 27  ? 7.753   4.238   -4.068  1.000 23.995  0 50  TRP A NE1 1 ? 
ATOM   237  C  CE2 . TRP A 1 27  ? 7.621   3.153   -3.257  1.000 21.825  0 50  TRP A CE2 1 ? 
ATOM   238  C  CE3 . TRP A 1 27  ? 7.625   2.665   -0.924  1.000 21.680  0 50  TRP A CE3 1 ? 
ATOM   239  C  CZ2 . TRP A 1 27  ? 7.470   1.802   -3.554  1.000 23.328  0 50  TRP A CZ2 1 ? 
ATOM   240  C  CZ3 . TRP A 1 27  ? 7.417   1.340   -1.209  1.000 23.845  0 50  TRP A CZ3 1 ? 
ATOM   241  C  CH2 . TRP A 1 27  ? 7.370   0.915   -2.518  1.000 26.612  0 50  TRP A CH2 1 ? 
ATOM   242  N  N   . LYS A 1 28  ? 8.607   9.105   0.399   1.000 23.182  0 51  LYS A N   1 ? 
ATOM   243  C  CA  . LYS A 1 28  ? 8.723   9.909   1.604   1.000 30.481  0 51  LYS A CA  1 ? 
ATOM   244  C  C   . LYS A 1 28  ? 7.998   9.186   2.740   1.000 25.437  0 51  LYS A C   1 ? 
ATOM   245  O  O   . LYS A 1 28  ? 6.944   8.587   2.526   1.000 27.334  0 51  LYS A O   1 ? 
ATOM   246  C  CB  . LYS A 1 28  ? 8.142   11.297  1.292   1.000 39.257  0 51  LYS A CB  1 ? 
ATOM   247  C  CG  . LYS A 1 28  ? 8.680   12.431  2.151   1.000 55.025  0 51  LYS A CG  1 ? 
ATOM   248  C  CD  . LYS A 1 28  ? 8.103   12.488  3.536   1.000 63.724  0 51  LYS A CD  1 ? 
ATOM   249  C  CE  . LYS A 1 28  ? 7.944   13.907  4.048   1.000 68.438  0 51  LYS A CE  1 ? 
ATOM   250  N  NZ  . LYS A 1 28  ? 9.261   14.532  4.303   1.000 64.439  0 51  LYS A NZ  1 ? 
ATOM   251  N  N   . GLY A 1 29  ? 8.602   9.139   3.934   1.000 26.279  0 52  GLY A N   1 ? 
ATOM   252  C  CA  . GLY A 1 29  ? 7.966   8.424   5.030   1.000 26.388  0 52  GLY A CA  1 ? 
ATOM   253  C  C   . GLY A 1 29  ? 8.744   8.508   6.334   1.000 27.375  0 52  GLY A C   1 ? 
ATOM   254  O  O   . GLY A 1 29  ? 9.768   9.181   6.390   1.000 31.084  0 52  GLY A O   1 ? 
ATOM   255  N  N   . GLY A 1 30  ? 8.248   7.794   7.350   1.000 26.160  0 53  GLY A N   1 ? 
ATOM   256  C  CA  . GLY A 1 30  ? 8.840   7.793   8.676   1.000 30.678  0 53  GLY A CA  1 ? 
ATOM   257  C  C   . GLY A 1 30  ? 9.855   6.662   8.853   1.000 29.743  0 53  GLY A C   1 ? 
ATOM   258  O  O   . GLY A 1 30  ? 9.899   5.991   9.884   1.000 32.725  0 53  GLY A O   1 ? 
ATOM   259  N  N   . TRP A 1 31  ? 10.733  6.510   7.859   1.000 28.231  0 54  TRP A N   1 ? 
ATOM   260  C  CA  . TRP A 1 31  ? 11.717  5.441   7.858   1.000 27.038  0 54  TRP A CA  1 ? 
ATOM   261  C  C   . TRP A 1 31  ? 12.589  5.508   9.110   1.000 26.524  0 54  TRP A C   1 ? 
ATOM   262  O  O   . TRP A 1 31  ? 12.830  4.488   9.745   1.000 31.718  0 54  TRP A O   1 ? 
ATOM   263  C  CB  . TRP A 1 31  ? 12.572  5.613   6.600   1.000 28.200  0 54  TRP A CB  1 ? 
ATOM   264  C  CG  . TRP A 1 31  ? 11.768  5.490   5.332   1.000 23.646  0 54  TRP A CG  1 ? 
ATOM   265  C  CD1 . TRP A 1 31  ? 11.334  6.501   4.546   1.000 23.952  0 54  TRP A CD1 1 ? 
ATOM   266  C  CD2 . TRP A 1 31  ? 11.361  4.269   4.690   1.000 22.201  0 54  TRP A CD2 1 ? 
ATOM   267  N  NE1 . TRP A 1 31  ? 10.668  5.994   3.462   1.000 21.005  0 54  TRP A NE1 1 ? 
ATOM   268  C  CE2 . TRP A 1 31  ? 10.679  4.635   3.519   1.000 20.966  0 54  TRP A CE2 1 ? 
ATOM   269  C  CE3 . TRP A 1 31  ? 11.510  2.909   4.979   1.000 22.383  0 54  TRP A CE3 1 ? 
ATOM   270  C  CZ2 . TRP A 1 31  ? 10.153  3.694   2.648   1.000 22.919  0 54  TRP A CZ2 1 ? 
ATOM   271  C  CZ3 . TRP A 1 31  ? 10.984  1.979   4.113   1.000 24.588  0 54  TRP A CZ3 1 ? 
ATOM   272  C  CH2 . TRP A 1 31  ? 10.287  2.373   2.985   1.000 22.475  0 54  TRP A CH2 1 ? 
ATOM   273  N  N   . ASP A 1 32  ? 13.090  6.701   9.404   1.000 27.904  0 55  ASP A N   1 ? 
ATOM   274  C  CA  . ASP A 1 32  ? 14.113  6.865   10.437  1.000 35.527  0 55  ASP A CA  1 ? 
ATOM   275  C  C   . ASP A 1 32  ? 13.502  6.779   11.833  1.000 40.071  0 55  ASP A C   1 ? 
ATOM   276  O  O   . ASP A 1 32  ? 14.216  6.476   12.780  1.000 47.634  0 55  ASP A O   1 ? 
ATOM   277  C  CB  . ASP A 1 32  ? 14.900  8.161   10.242  1.000 31.703  0 55  ASP A CB  1 ? 
ATOM   278  C  CG  . ASP A 1 32  ? 15.737  8.208   8.982   1.000 38.312  0 55  ASP A CG  1 ? 
ATOM   279  O  OD1 . ASP A 1 32  ? 15.900  7.162   8.352   1.000 42.954  0 55  ASP A OD1 1 ? 
ATOM   280  O  OD2 . ASP A 1 32  ? 16.238  9.285   8.651   1.000 51.103  0 55  ASP A OD2 1 ? 
ATOM   281  N  N   . GLU A 1 33  ? 12.181  6.929   11.951  1.000 39.855  0 56  GLU A N   1 ? 
ATOM   282  C  CA  . GLU A 1 33  ? 11.494  6.955   13.241  1.000 49.058  0 56  GLU A CA  1 ? 
ATOM   283  C  C   . GLU A 1 33  ? 11.092  5.548   13.692  1.000 48.019  0 56  GLU A C   1 ? 
ATOM   284  O  O   . GLU A 1 33  ? 10.734  5.344   14.846  1.000 48.875  0 56  GLU A O   1 ? 
ATOM   285  C  CB  . GLU A 1 33  ? 10.266  7.870   13.154  1.000 56.174  0 56  GLU A CB  1 ? 
ATOM   286  C  CG  . GLU A 1 33  ? 10.615  9.365   13.082  1.000 64.948  0 56  GLU A CG  1 ? 
ATOM   287  C  CD  . GLU A 1 33  ? 11.517  9.816   11.932  1.000 74.227  0 56  GLU A CD  1 ? 
ATOM   288  O  OE1 . GLU A 1 33  ? 12.608  10.401  12.210  1.000 70.644  0 56  GLU A OE1 1 ? 
ATOM   289  O  OE2 . GLU A 1 33  ? 11.140  9.588   10.751  1.000 68.094  0 56  GLU A OE2 1 ? 
ATOM   290  N  N   . SER A 1 34  ? 11.132  4.558   12.801  1.000 48.028  0 57  SER A N   1 ? 
ATOM   291  C  CA  . SER A 1 34  ? 10.666  3.232   13.161  1.000 49.625  0 57  SER A CA  1 ? 
ATOM   292  C  C   . SER A 1 34  ? 11.817  2.468   13.795  1.000 48.955  0 57  SER A C   1 ? 
ATOM   293  O  O   . SER A 1 34  ? 12.965  2.904   13.716  1.000 46.678  0 57  SER A O   1 ? 
ATOM   294  C  CB  . SER A 1 34  ? 10.090  2.482   11.974  1.000 48.516  0 57  SER A CB  1 ? 
ATOM   295  O  OG  . SER A 1 34  ? 11.050  2.297   10.944  1.000 51.742  0 57  SER A OG  1 ? 
ATOM   296  N  N   . LYS A 1 35  ? 11.491  1.306   14.369  1.000 51.760  0 58  LYS A N   1 ? 
ATOM   297  C  CA  . LYS A 1 35  ? 12.483  0.502   15.055  1.000 48.339  0 58  LYS A CA  1 ? 
ATOM   298  C  C   . LYS A 1 35  ? 12.662  -0.836  14.352  1.000 38.734  0 58  LYS A C   1 ? 
ATOM   299  O  O   . LYS A 1 35  ? 11.707  -1.578  14.110  1.000 36.390  0 58  LYS A O   1 ? 
ATOM   300  C  CB  . LYS A 1 35  ? 12.123  0.331   16.533  1.000 57.547  0 58  LYS A CB  1 ? 
ATOM   301  C  CG  . LYS A 1 35  ? 12.509  1.538   17.375  1.000 70.093  0 58  LYS A CG  1 ? 
ATOM   302  C  CD  . LYS A 1 35  ? 12.389  1.327   18.865  1.000 82.195  0 58  LYS A CD  1 ? 
ATOM   303  C  CE  . LYS A 1 35  ? 12.714  2.584   19.642  1.000 86.064  0 58  LYS A CE  1 ? 
ATOM   304  N  NZ  . LYS A 1 35  ? 12.639  2.347   21.102  1.000 90.548  0 58  LYS A NZ  1 ? 
ATOM   305  N  N   . GLY A 1 36  ? 13.931  -1.136  14.064  1.000 30.232  0 59  GLY A N   1 ? 
ATOM   306  C  CA  . GLY A 1 36  ? 14.301  -2.475  13.670  1.000 31.027  0 59  GLY A CA  1 ? 
ATOM   307  C  C   . GLY A 1 36  ? 13.914  -2.762  12.231  1.000 30.339  0 59  GLY A C   1 ? 
ATOM   308  O  O   . GLY A 1 36  ? 13.263  -1.965  11.555  1.000 24.498  0 59  GLY A O   1 ? 
ATOM   309  N  N   . ASP A 1 37  ? 14.354  -3.925  11.773  1.000 30.283  0 60  ASP A N   1 ? 
ATOM   310  C  CA  . ASP A 1 37  ? 13.994  -4.408  10.455  1.000 29.795  0 60  ASP A CA  1 ? 
ATOM   311  C  C   . ASP A 1 37  ? 12.480  -4.513  10.302  1.000 30.720  0 60  ASP A C   1 ? 
ATOM   312  O  O   . ASP A 1 37  ? 11.957  -4.251  9.213   1.000 26.503  0 60  ASP A O   1 ? 
ATOM   313  C  CB  . ASP A 1 37  ? 14.701  -5.736  10.201  1.000 32.741  0 60  ASP A CB  1 ? 
ATOM   314  C  CG  . ASP A 1 37  ? 16.164  -5.597  9.795   1.000 34.403  0 60  ASP A CG  1 ? 
ATOM   315  O  OD1 . ASP A 1 37  ? 16.647  -4.439  9.559   1.000 31.389  0 60  ASP A OD1 1 ? 
ATOM   316  O  OD2 . ASP A 1 37  ? 16.819  -6.655  9.669   1.000 33.127  0 60  ASP A OD2 1 ? 
ATOM   317  N  N   . GLU A 1 38  ? 11.768  -4.948  11.363  1.000 27.916  0 61  GLU A N   1 ? 
ATOM   318  C  CA  . GLU A 1 38  ? 10.312  -5.046  11.293  1.000 29.085  0 61  GLU A CA  1 ? 
ATOM   319  C  C   . GLU A 1 38  ? 9.669   -3.677  11.022  1.000 27.939  0 61  GLU A C   1 ? 
ATOM   320  O  O   . GLU A 1 38  ? 8.690   -3.597  10.286  1.000 28.658  0 61  GLU A O   1 ? 
ATOM   321  C  CB  . GLU A 1 38  ? 9.748   -5.723  12.542  1.000 37.229  0 61  GLU A CB  1 ? 
ATOM   322  C  CG  . GLU A 1 38  ? 9.908   -7.247  12.475  1.000 50.013  0 61  GLU A CG  1 ? 
ATOM   323  C  CD  . GLU A 1 38  ? 9.794   -8.077  13.753  1.000 66.802  0 61  GLU A CD  1 ? 
ATOM   324  O  OE1 . GLU A 1 38  ? 8.759   -7.973  14.484  1.000 71.891  0 61  GLU A OE1 1 ? 
ATOM   325  O  OE2 . GLU A 1 38  ? 10.732  -8.875  14.000  1.000 77.785  0 61  GLU A OE2 1 ? 
ATOM   326  N  N   . GLY A 1 39  ? 10.173  -2.607  11.628  1.000 24.060  0 62  GLY A N   1 ? 
ATOM   327  C  CA  . GLY A 1 39  ? 9.662   -1.274  11.347  1.000 23.841  0 62  GLY A CA  1 ? 
ATOM   328  C  C   . GLY A 1 39  ? 9.937   -0.852  9.883   1.000 23.403  0 62  GLY A C   1 ? 
ATOM   329  O  O   . GLY A 1 39  ? 9.128   -0.182  9.267   1.000 23.782  0 62  GLY A O   1 ? 
ATOM   330  N  N   . LEU A 1 40  ? 11.107  -1.206  9.330   1.000 24.846  0 63  LEU A N   1 ? 
ATOM   331  C  CA  . LEU A 1 40  ? 11.413  -0.891  7.937   1.000 22.980  0 63  LEU A CA  1 ? 
ATOM   332  C  C   . LEU A 1 40  ? 10.429  -1.596  7.018   1.000 21.436  0 63  LEU A C   1 ? 
ATOM   333  O  O   . LEU A 1 40  ? 9.935   -0.999  6.072   1.000 20.212  0 63  LEU A O   1 ? 
ATOM   334  C  CB  . LEU A 1 40  ? 12.852  -1.309  7.610   1.000 21.860  0 63  LEU A CB  1 ? 
ATOM   335  C  CG  . LEU A 1 40  ? 13.952  -0.460  8.242   1.000 24.755  0 63  LEU A CG  1 ? 
ATOM   336  C  CD1 . LEU A 1 40  ? 15.327  -0.969  7.816   1.000 26.369  0 63  LEU A CD1 1 ? 
ATOM   337  C  CD2 . LEU A 1 40  ? 13.811  1.002   7.894   1.000 24.356  0 63  LEU A CD2 1 ? 
ATOM   338  N  N   . LEU A 1 41  ? 10.177  -2.888  7.267   1.000 20.989  0 64  LEU A N   1 ? 
ATOM   339  C  CA  . LEU A 1 41  ? 9.277   -3.661  6.429   1.000 21.707  0 64  LEU A CA  1 ? 
ATOM   340  C  C   . LEU A 1 41  ? 7.834   -3.187  6.547   1.000 23.965  0 64  LEU A C   1 ? 
ATOM   341  O  O   . LEU A 1 41  ? 7.131   -3.153  5.541   1.000 22.682  0 64  LEU A O   1 ? 
ATOM   342  C  CB  . LEU A 1 41  ? 9.372   -5.140  6.798   1.000 21.623  0 64  LEU A CB  1 ? 
ATOM   343  C  CG  . LEU A 1 41  ? 10.676  -5.837  6.440   1.000 24.308  0 64  LEU A CG  1 ? 
ATOM   344  C  CD1 . LEU A 1 41  ? 10.799  -7.145  7.210   1.000 26.320  0 64  LEU A CD1 1 ? 
ATOM   345  C  CD2 . LEU A 1 41  ? 10.726  -6.064  4.926   1.000 25.103  0 64  LEU A CD2 1 ? 
ATOM   346  N  N   . ALA A 1 42  ? 7.414   -2.738  7.739   1.000 24.346  0 65  ALA A N   1 ? 
ATOM   347  C  CA  . ALA A 1 42  ? 6.040   -2.275  7.905   1.000 26.370  0 65  ALA A CA  1 ? 
ATOM   348  C  C   . ALA A 1 42  ? 5.846   -0.941  7.206   1.000 23.676  0 65  ALA A C   1 ? 
ATOM   349  O  O   . ALA A 1 42  ? 4.813   -0.710  6.615   1.000 24.271  0 65  ALA A O   1 ? 
ATOM   350  C  CB  . ALA A 1 42  ? 5.725   -2.155  9.399   1.000 27.738  0 65  ALA A CB  1 ? 
ATOM   351  N  N   . THR A 1 43  ? 6.863   -0.077  7.244   1.000 22.956  0 66  THR A N   1 ? 
ATOM   352  C  CA  . THR A 1 43  ? 6.803   1.172   6.508   1.000 22.061  0 66  THR A CA  1 ? 
ATOM   353  C  C   . THR A 1 43  ? 6.733   0.866   5.002   1.000 19.789  0 66  THR A C   1 ? 
ATOM   354  O  O   . THR A 1 43  ? 5.985   1.502   4.257   1.000 20.770  0 66  THR A O   1 ? 
ATOM   355  C  CB  . THR A 1 43  ? 7.988   2.059   6.914   1.000 24.303  0 66  THR A CB  1 ? 
ATOM   356  O  OG1 . THR A 1 43  ? 7.876   2.424   8.310   1.000 23.878  0 66  THR A OG1 1 ? 
ATOM   357  C  CG2 . THR A 1 43  ? 8.103   3.261   6.010   1.000 23.954  0 66  THR A CG2 1 ? 
ATOM   358  N  N   . PHE A 1 44  ? 7.600   -0.045  4.531   1.000 20.905  0 67  PHE A N   1 ? 
ATOM   359  C  CA  . PHE A 1 44  ? 7.638   -0.373  3.118   1.000 19.622  0 67  PHE A CA  1 ? 
ATOM   360  C  C   . PHE A 1 44  ? 6.274   -0.891  2.683   1.000 21.178  0 67  PHE A C   1 ? 
ATOM   361  O  O   . PHE A 1 44  ? 5.789   -0.521  1.606   1.000 21.358  0 67  PHE A O   1 ? 
ATOM   362  C  CB  . PHE A 1 44  ? 8.751   -1.362  2.793   1.000 19.903  0 67  PHE A CB  1 ? 
ATOM   363  C  CG  . PHE A 1 44  ? 8.936   -1.590  1.304   1.000 20.887  0 67  PHE A CG  1 ? 
ATOM   364  C  CD1 . PHE A 1 44  ? 9.741   -0.758  0.559   1.000 22.233  0 67  PHE A CD1 1 ? 
ATOM   365  C  CD2 . PHE A 1 44  ? 8.255   -2.604  0.657   1.000 23.081  0 67  PHE A CD2 1 ? 
ATOM   366  C  CE1 . PHE A 1 44  ? 9.901   -0.957  -0.801  1.000 22.467  0 67  PHE A CE1 1 ? 
ATOM   367  C  CE2 . PHE A 1 44  ? 8.363   -2.762  -0.710  1.000 22.230  0 67  PHE A CE2 1 ? 
ATOM   368  C  CZ  . PHE A 1 44  ? 9.234   -1.982  -1.419  1.000 22.101  0 67  PHE A CZ  1 ? 
ATOM   369  N  N   . LYS A 1 45  ? 5.693   -1.782  3.497   1.000 21.282  0 68  LYS A N   1 ? 
ATOM   370  C  CA  . LYS A 1 45  ? 4.412   -2.379  3.134   1.000 25.099  0 68  LYS A CA  1 ? 
ATOM   371  C  C   . LYS A 1 45  ? 3.362   -1.268  2.993   1.000 24.532  0 68  LYS A C   1 ? 
ATOM   372  O  O   . LYS A 1 45  ? 2.602   -1.205  2.009   1.000 26.233  0 68  LYS A O   1 ? 
ATOM   373  C  CB  . LYS A 1 45  ? 4.028   -3.465  4.145   1.000 29.284  0 68  LYS A CB  1 ? 
ATOM   374  C  CG  . LYS A 1 45  ? 2.670   -4.108  3.869   1.000 43.517  0 68  LYS A CG  1 ? 
ATOM   375  C  CD  . LYS A 1 45  ? 2.475   -5.495  4.452   1.000 55.941  0 68  LYS A CD  1 ? 
ATOM   376  C  CE  . LYS A 1 45  ? 1.444   -5.544  5.566   1.000 69.303  0 68  LYS A CE  1 ? 
ATOM   377  N  NZ  . LYS A 1 45  ? 1.387   -6.882  6.219   1.000 66.421  0 68  LYS A NZ  1 ? 
ATOM   378  N  N   . GLU A 1 46  ? 3.297   -0.363  3.973   1.000 25.410  0 69  GLU A N   1 ? 
ATOM   379  C  CA  . GLU A 1 46  ? 2.252   0.655   3.961   1.000 29.665  0 69  GLU A CA  1 ? 
ATOM   380  C  C   . GLU A 1 46  ? 2.468   1.653   2.822   1.000 26.952  0 69  GLU A C   1 ? 
ATOM   381  O  O   . GLU A 1 46  ? 1.531   2.036   2.110   1.000 27.240  0 69  GLU A O   1 ? 
ATOM   382  C  CB  . GLU A 1 46  ? 2.251   1.382   5.306   1.000 32.170  0 69  GLU A CB  1 ? 
ATOM   383  C  CG  . GLU A 1 46  ? 0.910   1.868   5.755   1.000 41.124  0 69  GLU A CG  1 ? 
ATOM   384  C  CD  . GLU A 1 46  ? -0.163  0.814   5.987   1.000 38.326  0 69  GLU A CD  1 ? 
ATOM   385  O  OE1 . GLU A 1 46  ? -0.026  -0.024  6.950   1.000 45.772  0 69  GLU A OE1 1 ? 
ATOM   386  O  OE2 . GLU A 1 46  ? -1.141  0.850   5.208   1.000 42.808  0 69  GLU A OE2 1 ? 
ATOM   387  N  N   . LEU A 1 47  ? 3.716   2.084   2.615   1.000 25.073  0 70  LEU A N   1 ? 
ATOM   388  C  CA  . LEU A 1 47  ? 3.997   3.050   1.560   1.000 23.682  0 70  LEU A CA  1 ? 
ATOM   389  C  C   . LEU A 1 47  ? 3.891   2.460   0.152   1.000 24.531  0 70  LEU A C   1 ? 
ATOM   390  O  O   . LEU A 1 47  ? 3.631   3.220   -0.784  1.000 23.042  0 70  LEU A O   1 ? 
ATOM   391  C  CB  . LEU A 1 47  ? 5.354   3.720   1.805   1.000 23.748  0 70  LEU A CB  1 ? 
ATOM   392  C  CG  . LEU A 1 47  ? 5.447   4.514   3.108   1.000 27.172  0 70  LEU A CG  1 ? 
ATOM   393  C  CD1 . LEU A 1 47  ? 6.791   5.198   3.237   1.000 27.074  0 70  LEU A CD1 1 ? 
ATOM   394  C  CD2 . LEU A 1 47  ? 4.357   5.554   3.191   1.000 28.096  0 70  LEU A CD2 1 ? 
ATOM   395  N  N   . SER A 1 48  ? 4.081   1.138   0.019   1.000 24.428  0 71  SER A N   1 ? 
ATOM   396  C  CA  . SER A 1 48  ? 3.856   0.402   -1.215  1.000 24.919  0 71  SER A CA  1 ? 
ATOM   397  C  C   . SER A 1 48  ? 2.490   0.749   -1.787  1.000 25.779  0 71  SER A C   1 ? 
ATOM   398  O  O   . SER A 1 48  ? 2.343   1.017   -2.982  1.000 26.029  0 71  SER A O   1 ? 
ATOM   399  C  CB  . SER A 1 48  ? 3.899   -1.104  -1.015  1.000 23.722  0 71  SER A CB  1 ? 
ATOM   400  O  OG  . SER A 1 48  ? 5.211   -1.512  -0.849  1.000 32.008  0 71  SER A OG  1 ? 
ATOM   401  N  N   . ALA A 1 49  ? 1.490   0.728   -0.916  1.000 28.397  0 72  ALA A N   1 ? 
ATOM   402  C  CA  . ALA A 1 49  ? 0.119   0.891   -1.358  1.000 27.779  0 72  ALA A CA  1 ? 
ATOM   403  C  C   . ALA A 1 49  ? -0.173  2.349   -1.700  1.000 28.491  0 72  ALA A C   1 ? 
ATOM   404  O  O   . ALA A 1 49  ? -1.199  2.630   -2.281  1.000 30.685  0 72  ALA A O   1 ? 
ATOM   405  C  CB  . ALA A 1 49  ? -0.796  0.401   -0.248  1.000 32.654  0 72  ALA A CB  1 ? 
ATOM   406  N  N   . ALA A 1 50  ? 0.632   3.272   -1.192  1.000 23.855  0 73  ALA A N   1 ? 
ATOM   407  C  CA  . ALA A 1 50  ? 0.505   4.687   -1.517  1.000 25.889  0 73  ALA A CA  1 ? 
ATOM   408  C  C   . ALA A 1 50  ? 1.179   5.008   -2.851  1.000 30.636  0 73  ALA A C   1 ? 
ATOM   409  O  O   . ALA A 1 50  ? 1.028   6.105   -3.376  1.000 28.275  0 73  ALA A O   1 ? 
ATOM   410  C  CB  . ALA A 1 50  ? 1.101   5.506   -0.410  1.000 26.993  0 73  ALA A CB  1 ? 
ATOM   411  N  N   . ASN A 1 51  ? 2.019   4.098   -3.360  1.000 27.097  0 74  ASN A N   1 ? 
ATOM   412  C  CA  . ASN A 1 51  ? 2.917   4.492   -4.438  1.000 28.921  0 74  ASN A CA  1 ? 
ATOM   413  C  C   . ASN A 1 51  ? 2.783   3.528   -5.607  1.000 29.315  0 74  ASN A C   1 ? 
ATOM   414  O  O   . ASN A 1 51  ? 3.697   3.418   -6.407  1.000 34.386  0 74  ASN A O   1 ? 
ATOM   415  C  CB  . ASN A 1 51  ? 4.364   4.578   -3.924  1.000 28.308  0 74  ASN A CB  1 ? 
ATOM   416  C  CG  . ASN A 1 51  ? 4.610   5.808   -3.114  1.000 29.402  0 74  ASN A CG  1 ? 
ATOM   417  O  OD1 . ASN A 1 51  ? 4.698   6.903   -3.674  1.000 35.954  0 74  ASN A OD1 1 ? 
ATOM   418  N  ND2 . ASN A 1 51  ? 4.636   5.665   -1.804  1.000 28.308  0 74  ASN A ND2 1 ? 
ATOM   419  N  N   . ASN A 1 52  ? 1.686   2.777   -5.650  1.000 30.490  0 75  ASN A N   1 ? 
ATOM   420  C  CA  . ASN A 1 52  ? 1.318   1.939   -6.778  1.000 36.271  0 75  ASN A CA  1 ? 
ATOM   421  C  C   . ASN A 1 52  ? 2.337   0.835   -7.038  1.000 37.795  0 75  ASN A C   1 ? 
ATOM   422  O  O   . ASN A 1 52  ? 2.578   0.490   -8.191  1.000 34.054  0 75  ASN A O   1 ? 
ATOM   423  C  CB  . ASN A 1 52  ? 1.167   2.754   -8.057  1.000 46.692  0 75  ASN A CB  1 ? 
ATOM   424  C  CG  . ASN A 1 52  ? 0.038   3.752   -7.946  1.000 58.385  0 75  ASN A CG  1 ? 
ATOM   425  O  OD1 . ASN A 1 52  ? -1.112  3.363   -7.743  1.000 67.537  0 75  ASN A OD1 1 ? 
ATOM   426  N  ND2 . ASN A 1 52  ? 0.370   5.029   -8.047  1.000 57.775  0 75  ASN A ND2 1 ? 
ATOM   427  N  N   . TYR A 1 53  ? 2.896   0.265   -5.968  1.000 32.015  0 76  TYR A N   1 ? 
ATOM   428  C  CA  . TYR A 1 53  ? 3.902   -0.774  -6.100  1.000 27.399  0 76  TYR A CA  1 ? 
ATOM   429  C  C   . TYR A 1 53  ? 3.280   -2.099  -6.541  1.000 26.648  0 76  TYR A C   1 ? 
ATOM   430  O  O   . TYR A 1 53  ? 2.258   -2.539  -6.049  1.000 28.701  0 76  TYR A O   1 ? 
ATOM   431  C  CB  . TYR A 1 53  ? 4.566   -0.882  -4.728  1.000 26.279  0 76  TYR A CB  1 ? 
ATOM   432  C  CG  . TYR A 1 53  ? 5.614   -1.970  -4.622  1.000 22.607  0 76  TYR A CG  1 ? 
ATOM   433  C  CD1 . TYR A 1 53  ? 6.890   -1.774  -5.143  1.000 24.401  0 76  TYR A CD1 1 ? 
ATOM   434  C  CD2 . TYR A 1 53  ? 5.324   -3.185  -4.049  1.000 25.599  0 76  TYR A CD2 1 ? 
ATOM   435  C  CE1 . TYR A 1 53  ? 7.867   -2.737  -5.009  1.000 25.395  0 76  TYR A CE1 1 ? 
ATOM   436  C  CE2 . TYR A 1 53  ? 6.301   -4.169  -3.922  1.000 24.993  0 76  TYR A CE2 1 ? 
ATOM   437  C  CZ  . TYR A 1 53  ? 7.574   -3.940  -4.414  1.000 25.093  0 76  TYR A CZ  1 ? 
ATOM   438  O  OH  . TYR A 1 53  ? 8.595   -4.879  -4.335  1.000 26.574  0 76  TYR A OH  1 ? 
ATOM   439  N  N   . LYS A 1 54  ? 3.969   -2.813  -7.425  1.000 29.268  0 77  LYS A N   1 ? 
ATOM   440  C  CA  . LYS A 1 54  ? 3.560   -4.158  -7.773  1.000 30.291  0 77  LYS A CA  1 ? 
ATOM   441  C  C   . LYS A 1 54  ? 4.617   -5.167  -7.318  1.000 24.421  0 77  LYS A C   1 ? 
ATOM   442  O  O   . LYS A 1 54  ? 4.314   -6.082  -6.580  1.000 26.377  0 77  LYS A O   1 ? 
ATOM   443  C  CB  . LYS A 1 54  ? 3.283   -4.234  -9.278  1.000 34.743  0 77  LYS A CB  1 ? 
ATOM   444  C  CG  . LYS A 1 54  ? 2.894   -5.648  -9.712  1.000 52.079  0 77  LYS A CG  1 ? 
ATOM   445  C  CD  . LYS A 1 54  ? 2.137   -5.792  -11.019 1.000 68.474  0 77  LYS A CD  1 ? 
ATOM   446  C  CE  . LYS A 1 54  ? 2.988   -6.287  -12.165 1.000 78.522  0 77  LYS A CE  1 ? 
ATOM   447  N  NZ  . LYS A 1 54  ? 3.975   -5.263  -12.584 1.000 87.312  0 77  LYS A NZ  1 ? 
ATOM   448  N  N   . ASP A 1 55  ? 5.858   -5.001  -7.804  1.000 25.496  0 78  ASP A N   1 ? 
ATOM   449  C  CA  . ASP A 1 55  ? 6.951   -5.925  -7.508  1.000 24.511  0 78  ASP A CA  1 ? 
ATOM   450  C  C   . ASP A 1 55  ? 8.264   -5.198  -7.738  1.000 21.908  0 78  ASP A C   1 ? 
ATOM   451  O  O   . ASP A 1 55  ? 8.257   -4.046  -8.201  1.000 21.524  0 78  ASP A O   1 ? 
ATOM   452  C  CB  . ASP A 1 55  ? 6.825   -7.224  -8.282  1.000 25.606  0 78  ASP A CB  1 ? 
ATOM   453  C  CG  . ASP A 1 55  ? 6.681   -7.024  -9.764  1.000 28.896  0 78  ASP A CG  1 ? 
ATOM   454  O  OD1 . ASP A 1 55  ? 7.426   -6.203  -10.331 1.000 30.967  0 78  ASP A OD1 1 ? 
ATOM   455  O  OD2 . ASP A 1 55  ? 5.890   -7.760  -10.351 1.000 31.249  0 78  ASP A OD2 1 ? 
ATOM   456  N  N   . VAL A 1 56  ? 9.384   -5.853  -7.361  1.000 23.449  0 79  VAL A N   1 ? 
ATOM   457  C  CA  . VAL A 1 56  ? 10.659  -5.169  -7.389  1.000 21.131  0 79  VAL A CA  1 ? 
ATOM   458  C  C   . VAL A 1 56  ? 11.073  -4.921  -8.840  1.000 20.965  0 79  VAL A C   1 ? 
ATOM   459  O  O   . VAL A 1 56  ? 11.604  -3.861  -9.159  1.000 21.519  0 79  VAL A O   1 ? 
ATOM   460  C  CB  . VAL A 1 56  ? 11.742  -5.950  -6.614  1.000 21.934  0 79  VAL A CB  1 ? 
ATOM   461  C  CG1 . VAL A 1 56  ? 13.062  -5.230  -6.647  1.000 22.498  0 79  VAL A CG1 1 ? 
ATOM   462  C  CG2 . VAL A 1 56  ? 11.345  -6.185  -5.163  1.000 19.849  0 79  VAL A CG2 1 ? 
ATOM   463  N  N   . ARG A 1 57  ? 10.845  -5.919  -9.724  1.000 20.912  0 80  ARG A N   1 ? 
ATOM   464  C  CA  . ARG A 1 57  ? 11.260  -5.771  -11.110 1.000 21.454  0 80  ARG A CA  1 ? 
ATOM   465  C  C   . ARG A 1 57  ? 10.574  -4.549  -11.739 1.000 21.461  0 80  ARG A C   1 ? 
ATOM   466  O  O   . ARG A 1 57  ? 11.216  -3.801  -12.465 1.000 23.058  0 80  ARG A O   1 ? 
ATOM   467  C  CB  . ARG A 1 57  ? 10.929  -7.026  -11.919 1.000 22.362  0 80  ARG A CB  1 ? 
ATOM   468  C  CG  . ARG A 1 57  ? 11.408  -6.902  -13.355 1.000 23.747  0 80  ARG A CG  1 ? 
ATOM   469  C  CD  . ARG A 1 57  ? 11.294  -8.232  -14.063 1.000 23.851  0 80  ARG A CD  1 ? 
ATOM   470  N  NE  . ARG A 1 57  ? 11.881  -8.134  -15.395 1.000 26.352  0 80  ARG A NE  1 ? 
ATOM   471  C  CZ  . ARG A 1 57  ? 11.947  -9.127  -16.261 1.000 23.838  0 80  ARG A CZ  1 ? 
ATOM   472  N  NH1 . ARG A 1 57  ? 11.377  -10.274 -15.982 1.000 24.989  0 80  ARG A NH1 1 ? 
ATOM   473  N  NH2 . ARG A 1 57  ? 12.618  -8.954  -17.388 1.000 24.781  0 80  ARG A NH2 1 ? 
ATOM   474  N  N   . SER A 1 58  ? 9.271   -4.390  -11.465 1.000 24.766  0 81  SER A N   1 ? 
ATOM   475  C  CA  . SER A 1 58  ? 8.472   -3.327  -12.076 1.000 26.120  0 81  SER A CA  1 ? 
ATOM   476  C  C   . SER A 1 58  ? 8.910   -1.973  -11.528 1.000 25.468  0 81  SER A C   1 ? 
ATOM   477  O  O   . SER A 1 58  ? 8.866   -0.953  -12.212 1.000 26.420  0 81  SER A O   1 ? 
ATOM   478  C  CB  . SER A 1 58  ? 7.018   -3.561  -11.832 1.000 29.326  0 81  SER A CB  1 ? 
ATOM   479  O  OG  . SER A 1 58  ? 6.588   -4.737  -12.489 1.000 36.499  0 81  SER A OG  1 ? 
ATOM   480  N  N   . LEU A 1 59  ? 9.342   -1.968  -10.262 1.000 22.794  0 82  LEU A N   1 ? 
ATOM   481  C  CA  . LEU A 1 59  ? 9.920   -0.762  -9.662  1.000 24.859  0 82  LEU A CA  1 ? 
ATOM   482  C  C   . LEU A 1 59  ? 11.216  -0.334  -10.357 1.000 23.393  0 82  LEU A C   1 ? 
ATOM   483  O  O   . LEU A 1 59  ? 11.457  0.861   -10.648 1.000 24.489  0 82  LEU A O   1 ? 
ATOM   484  C  CB  . LEU A 1 59  ? 10.125  -1.028  -8.158  1.000 25.309  0 82  LEU A CB  1 ? 
ATOM   485  C  CG  . LEU A 1 59  ? 10.603  0.162   -7.343  1.000 25.427  0 82  LEU A CG  1 ? 
ATOM   486  C  CD1 . LEU A 1 59  ? 9.493   1.163   -7.160  1.000 25.077  0 82  LEU A CD1 1 ? 
ATOM   487  C  CD2 . LEU A 1 59  ? 11.160  -0.264  -5.992  1.000 29.188  0 82  LEU A CD2 1 ? 
ATOM   488  N  N   . MET A 1 60  ? 12.099  -1.294  -10.602 1.000 21.975  0 83  MET A N   1 ? 
ATOM   489  C  CA  . MET A 1 60  ? 13.470  -1.038  -11.013 1.000 24.449  0 83  MET A CA  1 ? 
ATOM   490  C  C   . MET A 1 60  ? 13.599  -0.929  -12.538 1.000 25.684  0 83  MET A C   1 ? 
ATOM   491  O  O   . MET A 1 60  ? 14.265  -0.026  -13.016 1.000 28.173  0 83  MET A O   1 ? 
ATOM   492  C  CB  . MET A 1 60  ? 14.410  -2.123  -10.512 1.000 23.081  0 83  MET A CB  1 ? 
ATOM   493  C  CG  . MET A 1 60  ? 14.605  -2.042  -8.973  1.000 25.250  0 83  MET A CG  1 ? 
ATOM   494  S  SD  . MET A 1 60  ? 15.932  -3.104  -8.464  1.000 26.798  0 83  MET A SD  1 ? 
ATOM   495  C  CE  . MET A 1 60  ? 15.783  -2.911  -6.683  1.000 26.031  0 83  MET A CE  1 ? 
ATOM   496  N  N   . ASP A 1 61  ? 13.071  -1.889  -13.284 1.000 25.164  0 84  ASP A N   1 ? 
ATOM   497  C  CA  . ASP A 1 61  ? 13.323  -1.938  -14.726 1.000 24.576  0 84  ASP A CA  1 ? 
ATOM   498  C  C   . ASP A 1 61  ? 12.858  -0.631  -15.385 1.000 27.448  0 84  ASP A C   1 ? 
ATOM   499  O  O   . ASP A 1 61  ? 11.704  -0.228  -15.217 1.000 30.813  0 84  ASP A O   1 ? 
ATOM   500  C  CB  . ASP A 1 61  ? 12.534  -3.044  -15.402 1.000 27.354  0 84  ASP A CB  1 ? 
ATOM   501  C  CG  . ASP A 1 61  ? 13.192  -4.398  -15.358 1.000 30.009  0 84  ASP A CG  1 ? 
ATOM   502  O  OD1 . ASP A 1 61  ? 14.288  -4.501  -14.731 1.000 29.603  0 84  ASP A OD1 1 ? 
ATOM   503  O  OD2 . ASP A 1 61  ? 12.590  -5.327  -15.970 1.000 27.752  0 84  ASP A OD2 1 ? 
ATOM   504  N  N   . GLY A 1 62  ? 13.736  -0.033  -16.191 1.000 28.982  0 85  GLY A N   1 ? 
ATOM   505  C  CA  . GLY A 1 62  ? 13.361  1.145   -16.969 1.000 35.517  0 85  GLY A CA  1 ? 
ATOM   506  C  C   . GLY A 1 62  ? 13.493  2.439   -16.174 1.000 39.131  0 85  GLY A C   1 ? 
ATOM   507  O  O   . GLY A 1 62  ? 13.166  3.509   -16.687 1.000 35.478  0 85  GLY A O   1 ? 
ATOM   508  N  N   . ASN A 1 63  ? 13.924  2.334   -14.895 1.000 31.328  0 86  ASN A N   1 ? 
ATOM   509  C  CA  . ASN A 1 63  ? 14.129  3.522   -14.080 1.000 28.785  0 86  ASN A CA  1 ? 
ATOM   510  C  C   . ASN A 1 63  ? 15.596  3.585   -13.724 1.000 27.394  0 86  ASN A C   1 ? 
ATOM   511  O  O   . ASN A 1 63  ? 16.097  2.857   -12.859 1.000 24.485  0 86  ASN A O   1 ? 
ATOM   512  C  CB  . ASN A 1 63  ? 13.202  3.581   -12.866 1.000 29.796  0 86  ASN A CB  1 ? 
ATOM   513  C  CG  . ASN A 1 63  ? 13.368  4.875   -12.083 1.000 28.797  0 86  ASN A CG  1 ? 
ATOM   514  O  OD1 . ASN A 1 63  ? 14.327  5.617   -12.262 1.000 29.050  0 86  ASN A OD1 1 ? 
ATOM   515  N  ND2 . ASN A 1 63  ? 12.447  5.110   -11.179 1.000 31.115  0 86  ASN A ND2 1 ? 
ATOM   516  N  N   . PRO A 1 64  ? 16.369  4.484   -14.373 1.000 29.416  0 87  PRO A N   1 ? 
ATOM   517  C  CA  . PRO A 1 64  ? 17.801  4.622   -14.108 1.000 28.108  0 87  PRO A CA  1 ? 
ATOM   518  C  C   . PRO A 1 64  ? 18.226  4.959   -12.687 1.000 24.336  0 87  PRO A C   1 ? 
ATOM   519  O  O   . PRO A 1 64  ? 19.378  4.762   -12.315 1.000 25.923  0 87  PRO A O   1 ? 
ATOM   520  C  CB  . PRO A 1 64  ? 18.156  5.792   -15.031 1.000 32.578  0 87  PRO A CB  1 ? 
ATOM   521  C  CG  . PRO A 1 64  ? 17.221  5.589   -16.171 1.000 33.801  0 87  PRO A CG  1 ? 
ATOM   522  C  CD  . PRO A 1 64  ? 15.911  5.353   -15.468 1.000 35.318  0 87  PRO A CD  1 ? 
ATOM   523  N  N   . VAL A 1 65  ? 17.292  5.442   -11.860 1.000 25.699  0 88  VAL A N   1 ? 
ATOM   524  C  CA  . VAL A 1 65  ? 17.678  5.673   -10.482 1.000 25.448  0 88  VAL A CA  1 ? 
ATOM   525  C  C   . VAL A 1 65  ? 18.108  4.366   -9.812  1.000 23.277  0 88  VAL A C   1 ? 
ATOM   526  O  O   . VAL A 1 65  ? 18.930  4.420   -8.915  1.000 23.980  0 88  VAL A O   1 ? 
ATOM   527  C  CB  . VAL A 1 65  ? 16.775  6.565   -9.602  1.000 32.941  0 88  VAL A CB  1 ? 
ATOM   528  C  CG1 . VAL A 1 65  ? 15.828  7.502   -10.342 1.000 31.840  0 88  VAL A CG1 1 ? 
ATOM   529  C  CG2 . VAL A 1 65  ? 16.129  5.887   -8.436  1.000 29.559  0 88  VAL A CG2 1 ? 
ATOM   530  N  N   . TYR A 1 66  ? 17.629  3.227   -10.308 1.000 23.568  0 89  TYR A N   1 ? 
ATOM   531  C  CA  . TYR A 1 66  ? 18.049  1.941   -9.741  1.000 21.451  0 89  TYR A CA  1 ? 
ATOM   532  C  C   . TYR A 1 66  ? 19.264  1.334   -10.426 1.000 26.231  0 89  TYR A C   1 ? 
ATOM   533  O  O   . TYR A 1 66  ? 19.635  0.196   -10.114 1.000 26.909  0 89  TYR A O   1 ? 
ATOM   534  C  CB  . TYR A 1 66  ? 16.827  1.025   -9.782  1.000 21.877  0 89  TYR A CB  1 ? 
ATOM   535  C  CG  . TYR A 1 66  ? 15.698  1.481   -8.870  1.000 21.418  0 89  TYR A CG  1 ? 
ATOM   536  C  CD1 . TYR A 1 66  ? 15.725  1.236   -7.504  1.000 21.957  0 89  TYR A CD1 1 ? 
ATOM   537  C  CD2 . TYR A 1 66  ? 14.640  2.211   -9.372  1.000 21.029  0 89  TYR A CD2 1 ? 
ATOM   538  C  CE1 . TYR A 1 66  ? 14.721  1.699   -6.687  1.000 19.467  0 89  TYR A CE1 1 ? 
ATOM   539  C  CE2 . TYR A 1 66  ? 13.648  2.724   -8.546  1.000 20.396  0 89  TYR A CE2 1 ? 
ATOM   540  C  CZ  . TYR A 1 66  ? 13.689  2.450   -7.192  1.000 21.915  0 89  TYR A CZ  1 ? 
ATOM   541  O  OH  . TYR A 1 66  ? 12.653  2.912   -6.434  1.000 22.879  0 89  TYR A OH  1 ? 
ATOM   542  N  N   . GLY A 1 67  ? 19.922  2.101   -11.307 1.000 27.871  0 90  GLY A N   1 ? 
ATOM   543  C  CA  . GLY A 1 67  ? 21.232  1.739   -11.838 1.000 29.805  0 90  GLY A CA  1 ? 
ATOM   544  C  C   . GLY A 1 67  ? 21.137  0.794   -13.032 1.000 27.034  0 90  GLY A C   1 ? 
ATOM   545  O  O   . GLY A 1 67  ? 20.060  0.482   -13.495 1.000 27.636  0 90  GLY A O   1 ? 
ATOM   546  N  N   . GLU A 1 68  ? 22.278  0.298   -13.492 1.000 31.007  0 91  GLU A N   1 ? 
ATOM   547  C  CA  . GLU A 1 68  ? 22.309  -0.397  -14.765 1.000 29.022  0 91  GLU A CA  1 ? 
ATOM   548  C  C   . GLU A 1 68  ? 21.594  -1.746  -14.666 1.000 27.522  0 91  GLU A C   1 ? 
ATOM   549  O  O   . GLU A 1 68  ? 21.587  -2.389  -13.622 1.000 25.526  0 91  GLU A O   1 ? 
ATOM   550  C  CB  . GLU A 1 68  ? 23.743  -0.604  -15.251 1.000 34.351  0 91  GLU A CB  1 ? 
ATOM   551  C  CG  . GLU A 1 68  ? 24.640  -1.383  -14.324 1.000 37.051  0 91  GLU A CG  1 ? 
ATOM   552  C  CD  . GLU A 1 68  ? 26.047  -1.587  -14.884 1.000 52.935  0 91  GLU A CD  1 ? 
ATOM   553  O  OE1 . GLU A 1 68  ? 27.018  -1.684  -14.070 1.000 48.450  0 91  GLU A OE1 1 ? 
ATOM   554  O  OE2 . GLU A 1 68  ? 26.175  -1.708  -16.137 1.000 54.027  0 91  GLU A OE2 1 ? 
ATOM   555  N  N   . ASP A 1 69  ? 21.031  -2.166  -15.787 1.000 26.563  0 92  ASP A N   1 ? 
ATOM   556  C  CA  . ASP A 1 69  ? 20.412  -3.479  -15.878 1.000 29.753  0 92  ASP A CA  1 ? 
ATOM   557  C  C   . ASP A 1 69  ? 21.478  -4.545  -15.619 1.000 28.080  0 92  ASP A C   1 ? 
ATOM   558  O  O   . ASP A 1 69  ? 22.624  -4.369  -16.004 1.000 31.361  0 92  ASP A O   1 ? 
ATOM   559  C  CB  . ASP A 1 69  ? 19.765  -3.731  -17.233 1.000 35.260  0 92  ASP A CB  1 ? 
ATOM   560  C  CG  . ASP A 1 69  ? 18.576  -2.844  -17.559 1.000 46.434  0 92  ASP A CG  1 ? 
ATOM   561  O  OD1 . ASP A 1 69  ? 17.678  -2.674  -16.676 1.000 38.809  0 92  ASP A OD1 1 ? 
ATOM   562  O  OD2 . ASP A 1 69  ? 18.527  -2.377  -18.726 1.000 52.814  0 92  ASP A OD2 1 ? 
ATOM   563  N  N   . CYS A 1 70  ? 21.092  -5.594  -14.874 1.000 26.354  0 93  CYS A N   1 ? 
ATOM   564  C  CA  A CYS A 1 70  ? 21.910  -6.758  -14.568 0.500 26.727  0 93  CYS A CA  1 ? 
ATOM   565  C  CA  B CYS A 1 70  ? 21.958  -6.742  -14.626 0.500 27.293  0 93  CYS A CA  1 ? 
ATOM   566  C  C   . CYS A 1 70  ? 23.032  -6.426  -13.588 1.000 24.841  0 93  CYS A C   1 ? 
ATOM   567  O  O   . CYS A 1 70  ? 23.803  -7.302  -13.188 1.000 23.276  0 93  CYS A O   1 ? 
ATOM   568  C  CB  A CYS A 1 70  ? 22.467  -7.393  -15.836 0.500 28.315  0 93  CYS A CB  1 ? 
ATOM   569  C  CB  B CYS A 1 70  ? 22.725  -7.196  -15.865 0.500 29.477  0 93  CYS A CB  1 ? 
ATOM   570  S  SG  A CYS A 1 70  ? 21.149  -8.027  -16.903 0.500 28.511  0 93  CYS A SG  1 ? 
ATOM   571  S  SG  B CYS A 1 70  ? 21.729  -7.311  -17.374 0.500 31.957  0 93  CYS A SG  1 ? 
ATOM   572  N  N   . GLY A 1 71  ? 23.116  -5.168  -13.146 1.000 26.721  0 94  GLY A N   1 ? 
ATOM   573  C  CA  . GLY A 1 71  ? 24.161  -4.845  -12.190 1.000 25.981  0 94  GLY A CA  1 ? 
ATOM   574  C  C   . GLY A 1 71  ? 25.551  -5.125  -12.784 1.000 26.635  0 94  GLY A C   1 ? 
ATOM   575  O  O   . GLY A 1 71  ? 25.826  -4.793  -13.941 1.000 27.225  0 94  GLY A O   1 ? 
ATOM   576  N  N   . PHE A 1 72  ? 26.379  -5.800  -12.013 1.000 23.698  0 95  PHE A N   1 ? 
ATOM   577  C  CA  . PHE A 1 72  ? 27.743  -6.133  -12.393 1.000 26.662  0 95  PHE A CA  1 ? 
ATOM   578  C  C   . PHE A 1 72  ? 27.831  -7.479  -13.114 1.000 23.974  0 95  PHE A C   1 ? 
ATOM   579  O  O   . PHE A 1 72  ? 28.925  -7.848  -13.532 1.000 24.781  0 95  PHE A O   1 ? 
ATOM   580  C  CB  . PHE A 1 72  ? 28.592  -6.237  -11.127 1.000 25.319  0 95  PHE A CB  1 ? 
ATOM   581  C  CG  . PHE A 1 72  ? 28.690  -4.936  -10.377 1.000 29.551  0 95  PHE A CG  1 ? 
ATOM   582  C  CD1 . PHE A 1 72  ? 29.404  -3.873  -10.915 1.000 34.316  0 95  PHE A CD1 1 ? 
ATOM   583  C  CD2 . PHE A 1 72  ? 28.003  -4.755  -9.183  1.000 28.958  0 95  PHE A CD2 1 ? 
ATOM   584  C  CE1 . PHE A 1 72  ? 29.475  -2.662  -10.230 1.000 39.836  0 95  PHE A CE1 1 ? 
ATOM   585  C  CE2 . PHE A 1 72  ? 28.069  -3.545  -8.506  1.000 31.122  0 95  PHE A CE2 1 ? 
ATOM   586  C  CZ  . PHE A 1 72  ? 28.805  -2.504  -9.026  1.000 36.790  0 95  PHE A CZ  1 ? 
ATOM   587  N  N   . THR A 1 73  ? 26.709  -8.222  -13.191 1.000 23.120  0 96  THR A N   1 ? 
ATOM   588  C  CA  . THR A 1 73  ? 26.679  -9.496  -13.881 1.000 23.718  0 96  THR A CA  1 ? 
ATOM   589  C  C   . THR A 1 73  ? 26.558  -9.283  -15.389 1.000 23.904  0 96  THR A C   1 ? 
ATOM   590  O  O   . THR A 1 73  ? 26.190  -8.210  -15.879 1.000 24.610  0 96  THR A O   1 ? 
ATOM   591  C  CB  . THR A 1 73  ? 25.575  -10.415 -13.345 1.000 25.407  0 96  THR A CB  1 ? 
ATOM   592  O  OG1 . THR A 1 73  ? 24.302  -9.855  -13.684 1.000 23.563  0 96  THR A OG1 1 ? 
ATOM   593  C  CG2 . THR A 1 73  ? 25.723  -10.615 -11.851 1.000 28.260  0 96  THR A CG2 1 ? 
ATOM   594  N  N   . ASP A 1 74  ? 26.952  -10.308 -16.140 1.000 26.665  0 97  ASP A N   1 ? 
ATOM   595  C  CA  . ASP A 1 74  ? 27.024  -10.199 -17.592 1.000 26.961  0 97  ASP A CA  1 ? 
ATOM   596  C  C   . ASP A 1 74  ? 25.959  -11.079 -18.234 1.000 26.807  0 97  ASP A C   1 ? 
ATOM   597  O  O   . ASP A 1 74  ? 26.082  -12.309 -18.214 1.000 26.361  0 97  ASP A O   1 ? 
ATOM   598  C  CB  . ASP A 1 74  ? 28.427  -10.566 -18.066 1.000 29.975  0 97  ASP A CB  1 ? 
ATOM   599  C  CG  . ASP A 1 74  ? 28.652  -10.400 -19.570 1.000 32.282  0 97  ASP A CG  1 ? 
ATOM   600  O  OD1 . ASP A 1 74  ? 27.714  -9.929  -20.248 1.000 30.050  0 97  ASP A OD1 1 ? 
ATOM   601  O  OD2 . ASP A 1 74  ? 29.763  -10.755 -20.027 1.000 35.209  0 97  ASP A OD2 1 ? 
ATOM   602  N  N   . PRO A 1 75  ? 24.902  -10.507 -18.843 1.000 25.764  0 98  PRO A N   1 ? 
ATOM   603  C  CA  . PRO A 1 75  ? 23.896  -11.310 -19.536 1.000 28.982  0 98  PRO A CA  1 ? 
ATOM   604  C  C   . PRO A 1 75  ? 24.401  -12.004 -20.801 1.000 30.701  0 98  PRO A C   1 ? 
ATOM   605  O  O   . PRO A 1 75  ? 23.800  -13.002 -21.192 1.000 29.387  0 98  PRO A O   1 ? 
ATOM   606  C  CB  . PRO A 1 75  ? 22.823  -10.280 -19.900 1.000 30.617  0 98  PRO A CB  1 ? 
ATOM   607  C  CG  . PRO A 1 75  ? 23.601  -8.992  -20.051 1.000 31.911  0 98  PRO A CG  1 ? 
ATOM   608  C  CD  . PRO A 1 75  ? 24.613  -9.060  -18.934 1.000 28.281  0 98  PRO A CD  1 ? 
ATOM   609  N  N   . LYS A 1 76  ? 25.548  -11.545 -21.338 1.000 28.340  0 99  LYS A N   1 ? 
ATOM   610  C  CA  . LYS A 1 76  ? 26.251  -12.191 -22.460 1.000 30.798  0 99  LYS A CA  1 ? 
ATOM   611  C  C   . LYS A 1 76  ? 27.319  -13.155 -21.955 1.000 27.646  0 99  LYS A C   1 ? 
ATOM   612  O  O   . LYS A 1 76  ? 28.247  -13.552 -22.666 1.000 28.374  0 99  LYS A O   1 ? 
ATOM   613  C  CB  . LYS A 1 76  ? 27.010  -11.162 -23.305 1.000 34.489  0 99  LYS A CB  1 ? 
ATOM   614  C  CG  . LYS A 1 76  ? 26.205  -9.997  -23.834 1.000 43.748  0 99  LYS A CG  1 ? 
ATOM   615  C  CD  . LYS A 1 76  ? 25.169  -10.414 -24.829 1.000 57.811  0 99  LYS A CD  1 ? 
ATOM   616  C  CE  . LYS A 1 76  ? 24.508  -9.212  -25.472 1.000 72.013  0 99  LYS A CE  1 ? 
ATOM   617  N  NZ  . LYS A 1 76  ? 23.217  -9.591  -26.087 1.000 79.255  0 99  LYS A NZ  1 ? 
ATOM   618  N  N   . GLY A 1 77  ? 27.214  -13.551 -20.690 1.000 24.795  0 100 GLY A N   1 ? 
ATOM   619  C  CA  . GLY A 1 77  ? 28.183  -14.471 -20.173 1.000 23.199  0 100 GLY A CA  1 ? 
ATOM   620  C  C   . GLY A 1 77  ? 27.849  -15.911 -20.546 1.000 22.583  0 100 GLY A C   1 ? 
ATOM   621  O  O   . GLY A 1 77  ? 27.082  -16.196 -21.466 1.000 26.390  0 100 GLY A O   1 ? 
ATOM   622  N  N   . LYS A 1 78  ? 28.469  -16.811 -19.804 1.000 28.190  0 101 LYS A N   1 ? 
ATOM   623  C  CA  . LYS A 1 78  ? 28.417  -18.218 -20.127 1.000 26.126  0 101 LYS A CA  1 ? 
ATOM   624  C  C   . LYS A 1 78  ? 27.085  -18.797 -19.707 1.000 28.278  0 101 LYS A C   1 ? 
ATOM   625  O  O   . LYS A 1 78  ? 26.766  -18.758 -18.514 1.000 24.245  0 101 LYS A O   1 ? 
ATOM   626  C  CB  . LYS A 1 78  ? 29.525  -18.964 -19.400 1.000 25.827  0 101 LYS A CB  1 ? 
ATOM   627  C  CG  . LYS A 1 78  ? 29.479  -20.471 -19.574 1.000 25.329  0 101 LYS A CG  1 ? 
ATOM   628  C  CD  . LYS A 1 78  ? 30.448  -21.141 -18.663 1.000 28.956  0 101 LYS A CD  1 ? 
ATOM   629  C  CE  . LYS A 1 78  ? 30.389  -22.642 -18.748 1.000 34.536  0 101 LYS A CE  1 ? 
ATOM   630  N  NZ  . LYS A 1 78  ? 31.358  -23.205 -17.790 1.000 41.585  0 101 LYS A NZ  1 ? 
ATOM   631  N  N   . PRO A 1 79  ? 26.299  -19.366 -20.636 1.000 25.340  0 102 PRO A N   1 ? 
ATOM   632  C  CA  . PRO A 1 79  ? 25.074  -20.057 -20.254 1.000 24.956  0 102 PRO A CA  1 ? 
ATOM   633  C  C   . PRO A 1 79  ? 25.375  -21.270 -19.398 1.000 26.442  0 102 PRO A C   1 ? 
ATOM   634  O  O   . PRO A 1 79  ? 26.301  -22.043 -19.719 1.000 26.171  0 102 PRO A O   1 ? 
ATOM   635  C  CB  . PRO A 1 79  ? 24.437  -20.471 -21.579 1.000 26.583  0 102 PRO A CB  1 ? 
ATOM   636  C  CG  . PRO A 1 79  ? 25.035  -19.478 -22.554 1.000 26.699  0 102 PRO A CG  1 ? 
ATOM   637  C  CD  . PRO A 1 79  ? 26.459  -19.303 -22.104 1.000 25.691  0 102 PRO A CD  1 ? 
ATOM   638  N  N   . VAL A 1 80  ? 24.577  -21.421 -18.339 1.000 24.405  0 103 VAL A N   1 ? 
ATOM   639  C  CA  . VAL A 1 80  ? 24.780  -22.473 -17.364 1.000 24.866  0 103 VAL A CA  1 ? 
ATOM   640  C  C   . VAL A 1 80  ? 23.497  -23.279 -17.181 1.000 25.668  0 103 VAL A C   1 ? 
ATOM   641  O  O   . VAL A 1 80  ? 22.383  -22.828 -17.413 1.000 25.397  0 103 VAL A O   1 ? 
ATOM   642  C  CB  . VAL A 1 80  ? 25.302  -21.910 -16.019 1.000 27.104  0 103 VAL A CB  1 ? 
ATOM   643  C  CG1 . VAL A 1 80  ? 26.744  -21.416 -16.113 1.000 30.258  0 103 VAL A CG1 1 ? 
ATOM   644  C  CG2 . VAL A 1 80  ? 24.397  -20.804 -15.507 1.000 24.837  0 103 VAL A CG2 1 ? 
ATOM   645  N  N   . ALA A 1 81  ? 23.666  -24.516 -16.703 1.000 25.485  0 104 ALA A N   1 ? 
ATOM   646  C  CA  . ALA A 1 81  ? 22.517  -25.363 -16.484 1.000 26.669  0 104 ALA A CA  1 ? 
ATOM   647  C  C   . ALA A 1 81  ? 21.909  -24.961 -15.142 1.000 28.015  0 104 ALA A C   1 ? 
ATOM   648  O  O   . ALA A 1 81  ? 22.634  -24.800 -14.174 1.000 30.267  0 104 ALA A O   1 ? 
ATOM   649  C  CB  . ALA A 1 81  ? 22.949  -26.828 -16.499 1.000 29.499  0 104 ALA A CB  1 ? 
ATOM   650  N  N   . PRO A 1 82  ? 20.586  -24.885 -15.028 1.000 27.407  0 105 PRO A N   1 ? 
ATOM   651  C  CA  . PRO A 1 82  ? 19.956  -24.695 -13.717 1.000 35.288  0 105 PRO A CA  1 ? 
ATOM   652  C  C   . PRO A 1 82  ? 20.125  -25.878 -12.762 1.000 31.694  0 105 PRO A C   1 ? 
ATOM   653  O  O   . PRO A 1 82  ? 20.302  -27.020 -13.202 1.000 27.082  0 105 PRO A O   1 ? 
ATOM   654  C  CB  . PRO A 1 82  ? 18.484  -24.517 -14.076 1.000 34.269  0 105 PRO A CB  1 ? 
ATOM   655  C  CG  . PRO A 1 82  ? 18.311  -25.252 -15.353 1.000 38.022  0 105 PRO A CG  1 ? 
ATOM   656  C  CD  . PRO A 1 82  ? 19.630  -25.165 -16.092 1.000 32.208  0 105 PRO A CD  1 ? 
ATOM   657  N  N   . PRO A 1 83  ? 20.133  -25.614 -11.443 1.000 30.180  0 106 PRO A N   1 ? 
ATOM   658  C  CA  . PRO A 1 83  ? 20.119  -26.659 -10.421 1.000 29.145  0 106 PRO A CA  1 ? 
ATOM   659  C  C   . PRO A 1 83  ? 19.001  -27.649 -10.677 1.000 28.392  0 106 PRO A C   1 ? 
ATOM   660  O  O   . PRO A 1 83  ? 17.981  -27.272 -11.243 1.000 27.922  0 106 PRO A O   1 ? 
ATOM   661  C  CB  . PRO A 1 83  ? 19.819  -25.880 -9.131  1.000 29.560  0 106 PRO A CB  1 ? 
ATOM   662  C  CG  . PRO A 1 83  ? 20.394  -24.501 -9.404  1.000 30.993  0 106 PRO A CG  1 ? 
ATOM   663  C  CD  . PRO A 1 83  ? 20.122  -24.253 -10.866 1.000 30.380  0 106 PRO A CD  1 ? 
ATOM   664  N  N   A THR A 1 84  ? 19.178  -28.902 -10.250 0.500 25.839  0 107 THR A N   1 ? 
ATOM   665  N  N   B THR A 1 84  ? 19.217  -28.879 -10.201 0.500 27.401  0 107 THR A N   1 ? 
ATOM   666  C  CA  A THR A 1 84  ? 18.166  -29.927 -10.457 0.500 26.131  0 107 THR A CA  1 ? 
ATOM   667  C  CA  B THR A 1 84  ? 18.318  -30.002 -10.398 0.500 29.359  0 107 THR A CA  1 ? 
ATOM   668  C  C   A THR A 1 84  ? 17.269  -30.053 -9.230  0.500 28.425  0 107 THR A C   1 ? 
ATOM   669  C  C   B THR A 1 84  ? 17.403  -30.167 -9.187  0.500 30.235  0 107 THR A C   1 ? 
ATOM   670  O  O   A THR A 1 84  ? 16.280  -30.794 -9.263  0.500 27.834  0 107 THR A O   1 ? 
ATOM   671  O  O   B THR A 1 84  ? 16.528  -31.042 -9.183  0.500 29.734  0 107 THR A O   1 ? 
ATOM   672  C  CB  A THR A 1 84  ? 18.802  -31.299 -10.733 0.500 25.114  0 107 THR A CB  1 ? 
ATOM   673  C  CB  B THR A 1 84  ? 19.134  -31.285 -10.633 0.500 29.593  0 107 THR A CB  1 ? 
ATOM   674  O  OG1 A THR A 1 84  ? 19.863  -31.482 -9.799  0.500 18.853  0 107 THR A OG1 1 ? 
ATOM   675  O  OG1 B THR A 1 84  ? 19.702  -31.208 -11.944 0.500 28.263  0 107 THR A OG1 1 ? 
ATOM   676  N  N   . ASP A 1 85  ? 17.631  -29.343 -8.157  1.000 25.776  0 108 ASP A N   1 ? 
ATOM   677  C  CA  . ASP A 1 85  ? 16.973  -29.499 -6.865  1.000 28.313  0 108 ASP A CA  1 ? 
ATOM   678  C  C   . ASP A 1 85  ? 15.901  -28.437 -6.563  1.000 29.869  0 108 ASP A C   1 ? 
ATOM   679  O  O   . ASP A 1 85  ? 15.396  -28.378 -5.444  1.000 31.801  0 108 ASP A O   1 ? 
ATOM   680  C  CB  . ASP A 1 85  ? 18.025  -29.579 -5.767  1.000 27.263  0 108 ASP A CB  1 ? 
ATOM   681  C  CG  . ASP A 1 85  ? 18.851  -28.316 -5.634  1.000 33.932  0 108 ASP A CG  1 ? 
ATOM   682  O  OD1 . ASP A 1 85  ? 18.541  -27.330 -6.367  1.000 34.228  0 108 ASP A OD1 1 ? 
ATOM   683  O  OD2 . ASP A 1 85  ? 19.769  -28.311 -4.791  1.000 40.694  0 108 ASP A OD2 1 ? 
ATOM   684  N  N   . GLY A 1 86  ? 15.462  -27.668 -7.553  1.000 29.265  0 109 GLY A N   1 ? 
ATOM   685  C  CA  . GLY A 1 86  ? 14.362  -26.746 -7.328  1.000 30.831  0 109 GLY A CA  1 ? 
ATOM   686  C  C   . GLY A 1 86  ? 14.746  -25.612 -6.371  1.000 29.118  0 109 GLY A C   1 ? 
ATOM   687  O  O   . GLY A 1 86  ? 13.884  -25.122 -5.656  1.000 26.724  0 109 GLY A O   1 ? 
ATOM   688  N  N   . THR A 1 87  ? 16.034  -25.230 -6.347  1.000 24.148  0 110 THR A N   1 ? 
ATOM   689  C  CA  . THR A 1 87  ? 16.477  -24.110 -5.516  1.000 26.743  0 110 THR A CA  1 ? 
ATOM   690  C  C   . THR A 1 87  ? 17.377  -23.184 -6.318  1.000 23.616  0 110 THR A C   1 ? 
ATOM   691  O  O   . THR A 1 87  ? 17.778  -23.533 -7.443  1.000 23.821  0 110 THR A O   1 ? 
ATOM   692  C  CB  . THR A 1 87  ? 17.219  -24.599 -4.262  1.000 28.921  0 110 THR A CB  1 ? 
ATOM   693  O  OG1 . THR A 1 87  ? 18.491  -25.073 -4.695  1.000 30.599  0 110 THR A OG1 1 ? 
ATOM   694  C  CG2 . THR A 1 87  ? 16.448  -25.661 -3.493  1.000 30.743  0 110 THR A CG2 1 ? 
ATOM   695  N  N   . ALA A 1 88  ? 17.639  -21.977 -5.761  1.000 23.749  0 111 ALA A N   1 ? 
ATOM   696  C  CA  . ALA A 1 88  ? 18.795  -21.168 -6.140  1.000 21.966  0 111 ALA A CA  1 ? 
ATOM   697  C  C   . ALA A 1 88  ? 19.536  -20.935 -4.839  1.000 25.640  0 111 ALA A C   1 ? 
ATOM   698  O  O   . ALA A 1 88  ? 18.842  -20.848 -3.825  1.000 24.426  0 111 ALA A O   1 ? 
ATOM   699  C  CB  . ALA A 1 88  ? 18.421  -19.861 -6.798  1.000 23.796  0 111 ALA A CB  1 ? 
ATOM   700  N  N   . THR A 1 89  ? 20.867  -20.814 -4.905  1.000 22.893  0 112 THR A N   1 ? 
ATOM   701  C  CA  . THR A 1 89  ? 21.723  -20.615 -3.748  1.000 20.957  0 112 THR A CA  1 ? 
ATOM   702  C  C   . THR A 1 89  ? 22.394  -19.242 -3.842  1.000 24.230  0 112 THR A C   1 ? 
ATOM   703  O  O   . THR A 1 89  ? 22.962  -18.886 -4.853  1.000 23.779  0 112 THR A O   1 ? 
ATOM   704  C  CB  . THR A 1 89  ? 22.758  -21.744 -3.628  1.000 26.695  0 112 THR A CB  1 ? 
ATOM   705  O  OG1 . THR A 1 89  ? 21.980  -22.944 -3.581  1.000 27.165  0 112 THR A OG1 1 ? 
ATOM   706  C  CG2 . THR A 1 89  ? 23.600  -21.686 -2.368  1.000 26.107  0 112 THR A CG2 1 ? 
ATOM   707  N  N   . PHE A 1 90  ? 22.385  -18.502 -2.740  1.000 21.157  0 113 PHE A N   1 ? 
ATOM   708  C  CA  . PHE A 1 90  ? 23.105  -17.227 -2.660  1.000 21.170  0 113 PHE A CA  1 ? 
ATOM   709  C  C   . PHE A 1 90  ? 24.573  -17.445 -2.320  1.000 22.860  0 113 PHE A C   1 ? 
ATOM   710  O  O   . PHE A 1 90  ? 24.983  -18.546 -1.921  1.000 24.432  0 113 PHE A O   1 ? 
ATOM   711  C  CB  . PHE A 1 90  ? 22.446  -16.368 -1.587  1.000 21.201  0 113 PHE A CB  1 ? 
ATOM   712  C  CG  . PHE A 1 90  ? 22.341  -14.895 -1.860  1.000 20.909  0 113 PHE A CG  1 ? 
ATOM   713  C  CD1 . PHE A 1 90  ? 21.840  -14.426 -3.063  1.000 22.530  0 113 PHE A CD1 1 ? 
ATOM   714  C  CD2 . PHE A 1 90  ? 22.636  -13.993 -0.870  1.000 22.856  0 113 PHE A CD2 1 ? 
ATOM   715  C  CE1 . PHE A 1 90  ? 21.721  -13.069 -3.288  1.000 21.940  0 113 PHE A CE1 1 ? 
ATOM   716  C  CE2 . PHE A 1 90  ? 22.513  -12.634 -1.101  1.000 22.672  0 113 PHE A CE2 1 ? 
ATOM   717  C  CZ  . PHE A 1 90  ? 22.024  -12.177 -2.281  1.000 23.308  0 113 PHE A CZ  1 ? 
ATOM   718  N  N   . SER A 1 91  ? 25.368  -16.379 -2.456  1.000 19.217  0 114 SER A N   1 ? 
ATOM   719  C  CA  . SER A 1 91  ? 26.812  -16.453 -2.267  1.000 19.620  0 114 SER A CA  1 ? 
ATOM   720  C  C   . SER A 1 91  ? 27.174  -16.425 -0.780  1.000 21.764  0 114 SER A C   1 ? 
ATOM   721  O  O   . SER A 1 91  ? 28.330  -16.644 -0.406  1.000 22.938  0 114 SER A O   1 ? 
ATOM   722  C  CB  . SER A 1 91  ? 27.475  -15.342 -2.984  1.000 21.000  0 114 SER A CB  1 ? 
ATOM   723  O  OG  . SER A 1 91  ? 27.084  -14.056 -2.512  1.000 21.011  0 114 SER A OG  1 ? 
ATOM   724  N  N   . ARG A 1 92  ? 26.208  -16.037 0.043   1.000 21.554  0 115 ARG A N   1 ? 
ATOM   725  C  CA  . ARG A 1 92  ? 26.409  -15.851 1.474   1.000 21.778  0 115 ARG A CA  1 ? 
ATOM   726  C  C   . ARG A 1 92  ? 25.039  -15.879 2.123   1.000 21.383  0 115 ARG A C   1 ? 
ATOM   727  O  O   . ARG A 1 92  ? 24.039  -16.062 1.427   1.000 22.361  0 115 ARG A O   1 ? 
ATOM   728  C  CB  . ARG A 1 92  ? 27.171  -14.549 1.769   1.000 22.198  0 115 ARG A CB  1 ? 
ATOM   729  C  CG  . ARG A 1 92  ? 26.557  -13.308 1.139   1.000 22.801  0 115 ARG A CG  1 ? 
ATOM   730  C  CD  . ARG A 1 92  ? 27.239  -12.046 1.643   1.000 25.334  0 115 ARG A CD  1 ? 
ATOM   731  N  NE  . ARG A 1 92  ? 28.650  -12.027 1.324   1.000 28.885  0 115 ARG A NE  1 ? 
ATOM   732  C  CZ  . ARG A 1 92  ? 29.484  -11.052 1.678   1.000 31.007  0 115 ARG A CZ  1 ? 
ATOM   733  N  NH1 . ARG A 1 92  ? 29.107  -10.136 2.556   1.000 32.269  0 115 ARG A NH1 1 ? 
ATOM   734  N  NH2 . ARG A 1 92  ? 30.706  -11.033 1.177   1.000 32.745  0 115 ARG A NH2 1 ? 
ATOM   735  N  N   . GLY A 1 93  ? 24.977  -15.606 3.440   1.000 20.232  0 116 GLY A N   1 ? 
ATOM   736  C  CA  . GLY A 1 93  ? 23.710  -15.404 4.096   1.000 21.106  0 116 GLY A CA  1 ? 
ATOM   737  C  C   . GLY A 1 93  ? 23.168  -14.027 3.752   1.000 24.182  0 116 GLY A C   1 ? 
ATOM   738  O  O   . GLY A 1 93  ? 23.899  -13.221 3.209   1.000 23.124  0 116 GLY A O   1 ? 
ATOM   739  N  N   . ILE A 1 94  ? 21.910  -13.775 4.078   1.000 24.510  0 117 ILE A N   1 ? 
ATOM   740  C  CA  . ILE A 1 94  ? 21.263  -12.501 3.772   1.000 22.965  0 117 ILE A CA  1 ? 
ATOM   741  C  C   . ILE A 1 94  ? 21.161  -11.730 5.066   1.000 23.896  0 117 ILE A C   1 ? 
ATOM   742  O  O   . ILE A 1 94  ? 20.571  -12.234 6.013   1.000 25.104  0 117 ILE A O   1 ? 
ATOM   743  C  CB  . ILE A 1 94  ? 19.896  -12.700 3.115   1.000 25.799  0 117 ILE A CB  1 ? 
ATOM   744  C  CG1 . ILE A 1 94  ? 20.016  -13.305 1.718   1.000 25.605  0 117 ILE A CG1 1 ? 
ATOM   745  C  CG2 . ILE A 1 94  ? 19.102  -11.397 3.053   1.000 26.006  0 117 ILE A CG2 1 ? 
ATOM   746  C  CD1 . ILE A 1 94  ? 18.735  -13.955 1.239   1.000 25.397  0 117 ILE A CD1 1 ? 
ATOM   747  N  N   . VAL A 1 95  ? 21.755  -10.523 5.103   1.000 22.395  0 118 VAL A N   1 ? 
ATOM   748  C  CA  . VAL A 1 95  ? 21.831  -9.790  6.351   1.000 23.070  0 118 VAL A CA  1 ? 
ATOM   749  C  C   . VAL A 1 95  ? 21.120  -8.428  6.275   1.000 23.599  0 118 VAL A C   1 ? 
ATOM   750  O  O   . VAL A 1 95  ? 21.316  -7.635  7.189   1.000 24.765  0 118 VAL A O   1 ? 
ATOM   751  C  CB  . VAL A 1 95  ? 23.298  -9.598  6.796   1.000 26.128  0 118 VAL A CB  1 ? 
ATOM   752  C  CG1 . VAL A 1 95  ? 24.026  -10.937 6.941   1.000 28.864  0 118 VAL A CG1 1 ? 
ATOM   753  C  CG2 . VAL A 1 95  ? 24.085  -8.659  5.897   1.000 29.026  0 118 VAL A CG2 1 ? 
ATOM   754  N  N   . HIS A 1 96  ? 20.366  -8.134  5.198   1.000 22.533  0 119 HIS A N   1 ? 
ATOM   755  C  CA  . HIS A 1 96  ? 19.490  -6.963  5.161   1.000 21.375  0 119 HIS A CA  1 ? 
ATOM   756  C  C   . HIS A 1 96  ? 18.061  -7.368  4.892   1.000 22.596  0 119 HIS A C   1 ? 
ATOM   757  O  O   . HIS A 1 96  ? 17.816  -8.332  4.179   1.000 21.351  0 119 HIS A O   1 ? 
ATOM   758  C  CB  . HIS A 1 96  ? 19.868  -6.004  4.035   1.000 22.250  0 119 HIS A CB  1 ? 
ATOM   759  C  CG  . HIS A 1 96  ? 21.331  -5.746  3.923   1.000 25.015  0 119 HIS A CG  1 ? 
ATOM   760  N  ND1 . HIS A 1 96  ? 22.074  -5.288  4.987   1.000 25.177  0 119 HIS A ND1 1 ? 
ATOM   761  C  CD2 . HIS A 1 96  ? 22.178  -5.841  2.881   1.000 23.640  0 119 HIS A CD2 1 ? 
ATOM   762  C  CE1 . HIS A 1 96  ? 23.339  -5.118  4.599   1.000 27.788  0 119 HIS A CE1 1 ? 
ATOM   763  N  NE2 . HIS A 1 96  ? 23.430  -5.479  3.330   1.000 27.252  0 119 HIS A NE2 1 ? 
ATOM   764  N  N   . ALA A 1 97  ? 17.122  -6.590  5.415   1.000 22.358  0 120 ALA A N   1 ? 
ATOM   765  C  CA  . ALA A 1 97  ? 15.703  -6.815  5.199   1.000 21.383  0 120 ALA A CA  1 ? 
ATOM   766  C  C   . ALA A 1 97  ? 15.345  -6.289  3.817   1.000 21.467  0 120 ALA A C   1 ? 
ATOM   767  O  O   . ALA A 1 97  ? 16.048  -5.441  3.272   1.000 23.110  0 120 ALA A O   1 ? 
ATOM   768  C  CB  . ALA A 1 97  ? 14.888  -6.061  6.242   1.000 25.281  0 120 ALA A CB  1 ? 
ATOM   769  N  N   . GLY A 1 98  ? 14.252  -6.815  3.287   1.000 20.794  0 121 GLY A N   1 ? 
ATOM   770  C  CA  . GLY A 1 98  ? 13.549  -6.242  2.166   1.000 19.838  0 121 GLY A CA  1 ? 
ATOM   771  C  C   . GLY A 1 98  ? 13.185  -7.286  1.124   1.000 20.296  0 121 GLY A C   1 ? 
ATOM   772  O  O   . GLY A 1 98  ? 13.621  -8.452  1.171   1.000 20.975  0 121 GLY A O   1 ? 
ATOM   773  N  N   . PRO A 1 99  ? 12.366  -6.886  0.149   1.000 20.009  0 122 PRO A N   1 ? 
ATOM   774  C  CA  . PRO A 1 99  ? 11.794  -7.821  -0.824  1.000 19.747  0 122 PRO A CA  1 ? 
ATOM   775  C  C   . PRO A 1 99  ? 12.759  -8.311  -1.894  1.000 20.692  0 122 PRO A C   1 ? 
ATOM   776  O  O   . PRO A 1 99  ? 13.663  -7.608  -2.320  1.000 19.518  0 122 PRO A O   1 ? 
ATOM   777  C  CB  . PRO A 1 99  ? 10.654  -7.021  -1.452  1.000 20.657  0 122 PRO A CB  1 ? 
ATOM   778  C  CG  . PRO A 1 99  ? 11.127  -5.593  -1.345  1.000 20.801  0 122 PRO A CG  1 ? 
ATOM   779  C  CD  . PRO A 1 99  ? 11.870  -5.517  -0.041  1.000 19.586  0 122 PRO A CD  1 ? 
ATOM   780  N  N   . CYS A 1 100 ? 12.586  -9.559  -2.310  1.000 19.423  0 123 CYS A N   1 ? 
ATOM   781  C  CA  . CYS A 1 100 ? 13.379  -10.030 -3.435  1.000 23.174  0 123 CYS A CA  1 ? 
ATOM   782  C  C   . CYS A 1 100 ? 12.529  -10.955 -4.293  1.000 23.554  0 123 CYS A C   1 ? 
ATOM   783  O  O   . CYS A 1 100 ? 11.473  -11.436 -3.882  1.000 20.950  0 123 CYS A O   1 ? 
ATOM   784  C  CB  . CYS A 1 100 ? 14.669  -10.705 -2.988  1.000 28.312  0 123 CYS A CB  1 ? 
ATOM   785  S  SG  . CYS A 1 100 ? 14.392  -12.356 -2.316  0.800 28.754  0 123 CYS A SG  1 ? 
ATOM   786  N  N   . GLU A 1 101 ? 13.033  -11.212 -5.490  1.000 22.169  0 124 GLU A N   1 ? 
ATOM   787  C  CA  . GLU A 1 101 ? 12.318  -12.018 -6.459  1.000 20.782  0 124 GLU A CA  1 ? 
ATOM   788  C  C   . GLU A 1 101 ? 13.288  -12.565 -7.504  1.000 22.509  0 124 GLU A C   1 ? 
ATOM   789  O  O   . GLU A 1 101 ? 14.360  -12.005 -7.767  1.000 18.636  0 124 GLU A O   1 ? 
ATOM   790  C  CB  . GLU A 1 101 ? 11.191  -11.249 -7.109  1.000 24.732  0 124 GLU A CB  1 ? 
ATOM   791  C  CG  . GLU A 1 101 ? 11.559  -9.941  -7.641  1.000 28.689  0 124 GLU A CG  1 ? 
ATOM   792  C  CD  . GLU A 1 101 ? 10.336  -9.057  -7.838  1.000 29.264  0 124 GLU A CD  1 ? 
ATOM   793  O  OE1 . GLU A 1 101 ? 9.575   -8.755  -6.850  1.000 29.135  0 124 GLU A OE1 1 ? 
ATOM   794  O  OE2 . GLU A 1 101 ? 10.167  -8.640  -8.982  1.000 28.268  0 124 GLU A OE2 1 ? 
ATOM   795  N  N   . ILE A 1 102 ? 12.900  -13.716 -8.034  1.000 19.220  0 125 ILE A N   1 ? 
ATOM   796  C  CA  . ILE A 1 102 ? 13.592  -14.346 -9.141  1.000 20.539  0 125 ILE A CA  1 ? 
ATOM   797  C  C   . ILE A 1 102 ? 12.630  -14.481 -10.314 1.000 20.410  0 125 ILE A C   1 ? 
ATOM   798  O  O   . ILE A 1 102 ? 11.506  -14.913 -10.133 1.000 21.169  0 125 ILE A O   1 ? 
ATOM   799  C  CB  . ILE A 1 102 ? 14.116  -15.730 -8.717  1.000 22.197  0 125 ILE A CB  1 ? 
ATOM   800  C  CG1 . ILE A 1 102 ? 15.089  -15.605 -7.542  1.000 26.186  0 125 ILE A CG1 1 ? 
ATOM   801  C  CG2 . ILE A 1 102 ? 14.699  -16.430 -9.954  1.000 19.721  0 125 ILE A CG2 1 ? 
ATOM   802  C  CD1 . ILE A 1 102 ? 15.448  -16.889 -6.890  1.000 27.084  0 125 ILE A CD1 1 ? 
ATOM   803  N  N   . TRP A 1 103 ? 13.110  -14.154 -11.518 1.000 21.054  0 126 TRP A N   1 ? 
ATOM   804  C  CA  . TRP A 1 103 ? 12.365  -14.260 -12.755 1.000 20.382  0 126 TRP A CA  1 ? 
ATOM   805  C  C   . TRP A 1 103 ? 13.125  -15.154 -13.732 1.000 20.070  0 126 TRP A C   1 ? 
ATOM   806  O  O   . TRP A 1 103 ? 14.335  -15.122 -13.779 1.000 20.044  0 126 TRP A O   1 ? 
ATOM   807  C  CB  . TRP A 1 103 ? 12.189  -12.902 -13.427 1.000 21.559  0 126 TRP A CB  1 ? 
ATOM   808  C  CG  . TRP A 1 103 ? 11.357  -11.931 -12.646 1.000 24.051  0 126 TRP A CG  1 ? 
ATOM   809  C  CD1 . TRP A 1 103 ? 11.726  -11.299 -11.494 1.000 25.101  0 126 TRP A CD1 1 ? 
ATOM   810  C  CD2 . TRP A 1 103 ? 10.032  -11.472 -12.978 1.000 24.408  0 126 TRP A CD2 1 ? 
ATOM   811  N  NE1 . TRP A 1 103 ? 10.705  -10.486 -11.065 1.000 25.366  0 126 TRP A NE1 1 ? 
ATOM   812  C  CE2 . TRP A 1 103 ? 9.669   -10.554 -11.966 1.000 23.698  0 126 TRP A CE2 1 ? 
ATOM   813  C  CE3 . TRP A 1 103 ? 9.130   -11.733 -14.023 1.000 26.322  0 126 TRP A CE3 1 ? 
ATOM   814  C  CZ2 . TRP A 1 103 ? 8.435   -9.918  -11.963 1.000 29.347  0 126 TRP A CZ2 1 ? 
ATOM   815  C  CZ3 . TRP A 1 103 ? 7.921   -11.061 -14.033 1.000 27.738  0 126 TRP A CZ3 1 ? 
ATOM   816  C  CH2 . TRP A 1 103 ? 7.580   -10.168 -13.018 1.000 28.443  0 126 TRP A CH2 1 ? 
ATOM   817  N  N   . LEU A 1 104 ? 12.376  -15.907 -14.538 1.000 22.831  0 127 LEU A N   1 ? 
ATOM   818  C  CA  . LEU A 1 104 ? 12.886  -16.624 -15.688 1.000 23.859  0 127 LEU A CA  1 ? 
ATOM   819  C  C   . LEU A 1 104 ? 12.199  -16.053 -16.924 1.000 23.718  0 127 LEU A C   1 ? 
ATOM   820  O  O   . LEU A 1 104 ? 10.995  -16.220 -17.066 1.000 25.268  0 127 LEU A O   1 ? 
ATOM   821  C  CB  . LEU A 1 104 ? 12.600  -18.117 -15.524 1.000 25.959  0 127 LEU A CB  1 ? 
ATOM   822  C  CG  . LEU A 1 104 ? 13.307  -18.797 -14.361 1.000 28.722  0 127 LEU A CG  1 ? 
ATOM   823  C  CD1 . LEU A 1 104 ? 13.013  -20.305 -14.357 1.000 35.577  0 127 LEU A CD1 1 ? 
ATOM   824  C  CD2 . LEU A 1 104 ? 14.812  -18.572 -14.399 1.000 31.960  0 127 LEU A CD2 1 ? 
ATOM   825  N  N   . ASP A 1 105 ? 12.959  -15.299 -17.744 1.000 26.672  0 128 ASP A N   1 ? 
ATOM   826  C  CA  . ASP A 1 105 ? 12.416  -14.426 -18.787 1.000 28.483  0 128 ASP A CA  1 ? 
ATOM   827  C  C   . ASP A 1 105 ? 11.322  -13.553 -18.163 1.000 29.498  0 128 ASP A C   1 ? 
ATOM   828  O  O   . ASP A 1 105 ? 11.632  -12.872 -17.183 1.000 27.813  0 128 ASP A O   1 ? 
ATOM   829  C  CB  . ASP A 1 105 ? 12.060  -15.232 -20.041 1.000 31.386  0 128 ASP A CB  1 ? 
ATOM   830  C  CG  . ASP A 1 105 ? 13.262  -15.741 -20.825 1.000 40.866  0 128 ASP A CG  1 ? 
ATOM   831  O  OD1 . ASP A 1 105 ? 14.410  -15.251 -20.583 1.000 36.082  0 128 ASP A OD1 1 ? 
ATOM   832  O  OD2 . ASP A 1 105 ? 13.049  -16.674 -21.657 1.000 36.341  0 128 ASP A OD2 1 ? 
ATOM   833  N  N   A ASP A 1 106 ? 10.069  -13.578 -18.667 0.500 28.311  0 129 ASP A N   1 ? 
ATOM   834  N  N   B ASP A 1 106 ? 10.076  -13.706 -18.653 0.500 28.921  0 129 ASP A N   1 ? 
ATOM   835  C  CA  A ASP A 1 106 ? 9.020   -12.709 -18.137 0.500 29.861  0 129 ASP A CA  1 ? 
ATOM   836  C  CA  B ASP A 1 106 ? 8.938   -12.865 -18.320 0.500 30.552  0 129 ASP A CA  1 ? 
ATOM   837  C  C   A ASP A 1 106 ? 8.108   -13.445 -17.149 0.500 30.416  0 129 ASP A C   1 ? 
ATOM   838  C  C   B ASP A 1 106 ? 8.114   -13.452 -17.169 0.500 30.829  0 129 ASP A C   1 ? 
ATOM   839  O  O   A ASP A 1 106 ? 6.994   -12.997 -16.891 0.500 29.529  0 129 ASP A O   1 ? 
ATOM   840  O  O   B ASP A 1 106 ? 7.067   -12.913 -16.822 0.500 29.865  0 129 ASP A O   1 ? 
ATOM   841  C  CB  A ASP A 1 106 ? 8.135   -12.109 -19.238 0.500 32.938  0 129 ASP A CB  1 ? 
ATOM   842  C  CB  B ASP A 1 106 ? 8.030   -12.732 -19.549 0.500 34.111  0 129 ASP A CB  1 ? 
ATOM   843  C  CG  A ASP A 1 106 ? 8.865   -11.215 -20.221 0.500 37.206  0 129 ASP A CG  1 ? 
ATOM   844  C  CG  B ASP A 1 106 ? 7.561   -14.076 -20.101 0.500 35.859  0 129 ASP A CG  1 ? 
ATOM   845  O  OD1 A ASP A 1 106 ? 9.735   -10.431 -19.780 0.500 45.477  0 129 ASP A OD1 1 ? 
ATOM   846  O  OD1 B ASP A 1 106 ? 8.418   -14.964 -20.330 0.500 37.021  0 129 ASP A OD1 1 ? 
ATOM   847  O  OD2 A ASP A 1 106 ? 8.536   -11.286 -21.409 0.500 43.213  0 129 ASP A OD2 1 ? 
ATOM   848  O  OD2 B ASP A 1 106 ? 6.339   -14.229 -20.329 0.500 50.931  0 129 ASP A OD2 1 ? 
ATOM   849  N  N   . LYS A 1 107 ? 8.572   -14.568 -16.600 1.000 27.662  0 130 LYS A N   1 ? 
ATOM   850  C  CA  . LYS A 1 107 ? 7.811   -15.314 -15.619 1.000 28.495  0 130 LYS A CA  1 ? 
ATOM   851  C  C   . LYS A 1 107 ? 8.416   -15.143 -14.229 1.000 26.651  0 130 LYS A C   1 ? 
ATOM   852  O  O   . LYS A 1 107 ? 9.558   -15.529 -14.033 1.000 23.208  0 130 LYS A O   1 ? 
ATOM   853  C  CB  . LYS A 1 107 ? 7.846   -16.810 -15.924 1.000 30.240  0 130 LYS A CB  1 ? 
ATOM   854  C  CG  . LYS A 1 107 ? 6.911   -17.637 -15.063 1.000 33.588  0 130 LYS A CG  1 ? 
ATOM   855  C  CD  . LYS A 1 107 ? 6.978   -19.142 -15.320 1.000 37.813  0 130 LYS A CD  1 ? 
ATOM   856  C  CE  . LYS A 1 107 ? 5.928   -19.890 -14.521 1.000 46.491  0 130 LYS A CE  1 ? 
ATOM   857  N  NZ  . LYS A 1 107 ? 6.036   -21.357 -14.715 1.000 51.870  0 130 LYS A NZ  1 ? 
ATOM   858  N  N   . MET A 1 108 ? 7.632   -14.680 -13.254 1.000 24.831  0 131 MET A N   1 ? 
ATOM   859  C  CA  . MET A 1 108 ? 8.155   -14.576 -11.893 1.000 25.389  0 131 MET A CA  1 ? 
ATOM   860  C  C   . MET A 1 108 ? 8.057   -15.953 -11.244 1.000 24.151  0 131 MET A C   1 ? 
ATOM   861  O  O   . MET A 1 108 ? 6.985   -16.561 -11.259 1.000 28.215  0 131 MET A O   1 ? 
ATOM   862  C  CB  . MET A 1 108 ? 7.377   -13.593 -11.033 1.000 26.284  0 131 MET A CB  1 ? 
ATOM   863  C  CG  . MET A 1 108 ? 8.049   -13.438 -9.651  1.000 34.954  0 131 MET A CG  1 ? 
ATOM   864  S  SD  . MET A 1 108 ? 7.383   -12.000 -8.830  1.000 47.368  0 131 MET A SD  1 ? 
ATOM   865  C  CE  . MET A 1 108 ? 5.834   -12.753 -8.349  1.000 43.651  0 131 MET A CE  1 ? 
ATOM   866  N  N   . VAL A 1 109 ? 9.171   -16.526 -10.831 1.000 21.306  0 132 VAL A N   1 ? 
ATOM   867  C  CA  . VAL A 1 109 ? 9.124   -17.870 -10.259 1.000 21.630  0 132 VAL A CA  1 ? 
ATOM   868  C  C   . VAL A 1 109 ? 9.276   -17.897 -8.736  1.000 22.548  0 132 VAL A C   1 ? 
ATOM   869  O  O   . VAL A 1 109 ? 9.007   -18.930 -8.123  1.000 22.971  0 132 VAL A O   1 ? 
ATOM   870  C  CB  . VAL A 1 109 ? 10.144  -18.807 -10.905 1.000 22.433  0 132 VAL A CB  1 ? 
ATOM   871  C  CG1 . VAL A 1 109 ? 9.772   -19.033 -12.344 1.000 21.438  0 132 VAL A CG1 1 ? 
ATOM   872  C  CG2 . VAL A 1 109 ? 11.589  -18.357 -10.767 1.000 23.158  0 132 VAL A CG2 1 ? 
ATOM   873  N  N   . LEU A 1 110 ? 9.733   -16.793 -8.133  1.000 20.782  0 133 LEU A N   1 ? 
ATOM   874  C  CA  . LEU A 1 110 ? 9.747   -16.716 -6.682  1.000 21.956  0 133 LEU A CA  1 ? 
ATOM   875  C  C   . LEU A 1 110 ? 9.744   -15.250 -6.265  1.000 22.915  0 133 LEU A C   1 ? 
ATOM   876  O  O   . LEU A 1 110 ? 10.485  -14.467 -6.860  1.000 21.926  0 133 LEU A O   1 ? 
ATOM   877  C  CB  . LEU A 1 110 ? 10.986  -17.418 -6.121  1.000 24.150  0 133 LEU A CB  1 ? 
ATOM   878  C  CG  . LEU A 1 110 ? 11.075  -17.466 -4.596  1.000 27.070  0 133 LEU A CG  1 ? 
ATOM   879  C  CD1 . LEU A 1 110 ? 9.923   -18.291 -4.000  1.000 33.394  0 133 LEU A CD1 1 ? 
ATOM   880  C  CD2 . LEU A 1 110 ? 12.366  -18.085 -4.114  1.000 30.063  0 133 LEU A CD2 1 ? 
ATOM   881  N  N   . GLN A 1 111 ? 8.938   -14.939 -5.243  1.000 23.010  0 134 GLN A N   1 ? 
ATOM   882  C  CA  . GLN A 1 111 ? 8.866   -13.590 -4.686  1.000 25.427  0 134 GLN A CA  1 ? 
ATOM   883  C  C   . GLN A 1 111 ? 8.656   -13.725 -3.188  1.000 25.246  0 134 GLN A C   1 ? 
ATOM   884  O  O   . GLN A 1 111 ? 7.968   -14.642 -2.735  1.000 21.160  0 134 GLN A O   1 ? 
ATOM   885  C  CB  . GLN A 1 111 ? 7.714   -12.818 -5.337  1.000 29.536  0 134 GLN A CB  1 ? 
ATOM   886  C  CG  . GLN A 1 111 ? 7.525   -11.408 -4.788  1.000 37.729  0 134 GLN A CG  1 ? 
ATOM   887  C  CD  . GLN A 1 111 ? 6.803   -11.279 -3.457  1.000 44.901  0 134 GLN A CD  1 ? 
ATOM   888  O  OE1 . GLN A 1 111 ? 6.962   -10.292 -2.726  1.000 43.710  0 134 GLN A OE1 1 ? 
ATOM   889  N  NE2 . GLN A 1 111 ? 5.997   -12.274 -3.124  1.000 47.209  0 134 GLN A NE2 1 ? 
ATOM   890  N  N   . ASN A 1 112 ? 9.291   -12.831 -2.427  1.000 20.963  0 135 ASN A N   1 ? 
ATOM   891  C  CA  . ASN A 1 112 ? 9.044   -12.769 -1.002  1.000 19.959  0 135 ASN A CA  1 ? 
ATOM   892  C  C   . ASN A 1 112 ? 9.218   -11.338 -0.533  1.000 20.490  0 135 ASN A C   1 ? 
ATOM   893  O  O   . ASN A 1 112 ? 10.099  -10.639 -1.036  1.000 20.704  0 135 ASN A O   1 ? 
ATOM   894  C  CB  . ASN A 1 112 ? 9.975   -13.713 -0.267  1.000 21.225  0 135 ASN A CB  1 ? 
ATOM   895  C  CG  . ASN A 1 112 ? 9.491   -14.023 1.127   1.000 24.546  0 135 ASN A CG  1 ? 
ATOM   896  O  OD1 . ASN A 1 112 ? 9.734   -13.232 2.027   1.000 24.158  0 135 ASN A OD1 1 ? 
ATOM   897  N  ND2 . ASN A 1 112 ? 8.799   -15.141 1.337   1.000 24.649  0 135 ASN A ND2 1 ? 
ATOM   898  N  N   . ASP A 1 113 ? 8.403   -10.940 0.447   1.000 21.865  0 136 ASP A N   1 ? 
ATOM   899  C  CA  . ASP A 1 113 ? 8.477   -9.570  0.965   1.000 24.009  0 136 ASP A CA  1 ? 
ATOM   900  C  C   . ASP A 1 113 ? 9.717   -9.326  1.838   1.000 21.567  0 136 ASP A C   1 ? 
ATOM   901  O  O   . ASP A 1 113 ? 10.111  -8.174  2.040   1.000 23.130  0 136 ASP A O   1 ? 
ATOM   902  C  CB  . ASP A 1 113 ? 7.228   -9.241  1.774   1.000 25.295  0 136 ASP A CB  1 ? 
ATOM   903  C  CG  . ASP A 1 113 ? 5.981   -9.109  0.905   1.000 31.123  0 136 ASP A CG  1 ? 
ATOM   904  O  OD1 . ASP A 1 113 ? 6.099   -8.869  -0.314  1.000 33.981  0 136 ASP A OD1 1 ? 
ATOM   905  O  OD2 . ASP A 1 113 ? 4.895   -9.260  1.441   1.000 39.553  0 136 ASP A OD2 1 ? 
ATOM   906  N  N   . ASP A 1 114 ? 10.346  -10.397 2.329   1.000 21.883  0 137 ASP A N   1 ? 
ATOM   907  C  CA  . ASP A 1 114 ? 11.505  -10.284 3.197   1.000 23.210  0 137 ASP A CA  1 ? 
ATOM   908  C  C   . ASP A 1 114 ? 12.405  -11.506 3.083   1.000 23.048  0 137 ASP A C   1 ? 
ATOM   909  O  O   . ASP A 1 114 ? 12.299  -12.449 3.875   1.000 24.704  0 137 ASP A O   1 ? 
ATOM   910  C  CB  . ASP A 1 114 ? 11.135  -10.085 4.670   1.000 24.603  0 137 ASP A CB  1 ? 
ATOM   911  C  CG  . ASP A 1 114 ? 12.366  -9.780  5.510   1.000 33.018  0 137 ASP A CG  1 ? 
ATOM   912  O  OD1 . ASP A 1 114 ? 13.246  -8.981  5.026   1.000 32.716  0 137 ASP A OD1 1 ? 
ATOM   913  O  OD2 . ASP A 1 114 ? 12.478  -10.355 6.626   1.000 35.109  0 137 ASP A OD2 1 ? 
ATOM   914  N  N   . CYS A 1 115 ? 13.350  -11.401 2.169   1.000 22.674  0 138 CYS A N   1 ? 
ATOM   915  C  CA  . CYS A 1 115 ? 14.191  -12.526 1.809   1.000 25.308  0 138 CYS A CA  1 ? 
ATOM   916  C  C   . CYS A 1 115 ? 15.039  -12.934 3.013   1.000 25.040  0 138 CYS A C   1 ? 
ATOM   917  O  O   . CYS A 1 115 ? 15.301  -14.114 3.229   1.000 24.813  0 138 CYS A O   1 ? 
ATOM   918  C  CB  . CYS A 1 115 ? 14.855  -12.204 0.464   1.000 31.646  0 138 CYS A CB  1 ? 
ATOM   919  S  SG  . CYS A 1 115 ? 13.635  -12.306 -0.901  0.800 30.070  0 138 CYS A SG  1 ? 
ATOM   920  N  N   . GLN A 1 116 ? 15.404  -11.961 3.850   1.000 22.645  0 139 GLN A N   1 ? 
ATOM   921  C  CA  . GLN A 1 116 ? 16.180  -12.201 5.049   1.000 25.735  0 139 GLN A CA  1 ? 
ATOM   922  C  C   . GLN A 1 116 ? 15.554  -13.267 5.942   1.000 25.573  0 139 GLN A C   1 ? 
ATOM   923  O  O   . GLN A 1 116 ? 16.255  -14.179 6.379   1.000 29.032  0 139 GLN A O   1 ? 
ATOM   924  C  CB  . GLN A 1 116 ? 16.364  -10.895 5.817   1.000 24.250  0 139 GLN A CB  1 ? 
ATOM   925  C  CG  . GLN A 1 116 ? 17.206  -11.052 7.056   1.000 26.964  0 139 GLN A CG  1 ? 
ATOM   926  C  CD  . GLN A 1 116 ? 17.582  -9.721  7.645   1.000 28.529  0 139 GLN A CD  1 ? 
ATOM   927  O  OE1 . GLN A 1 116 ? 18.755  -9.411  7.812   1.000 33.944  0 139 GLN A OE1 1 ? 
ATOM   928  N  NE2 . GLN A 1 116 ? 16.574  -8.969  8.057   1.000 30.898  0 139 GLN A NE2 1 ? 
ATOM   929  N  N   . SER A 1 117 ? 14.271  -13.137 6.252   1.000 26.842  0 140 SER A N   1 ? 
ATOM   930  C  CA  . SER A 1 117 ? 13.613  -14.068 7.166   1.000 30.822  0 140 SER A CA  1 ? 
ATOM   931  C  C   . SER A 1 117 ? 13.195  -15.357 6.457   1.000 32.342  0 140 SER A C   1 ? 
ATOM   932  O  O   . SER A 1 117 ? 13.025  -16.395 7.101   1.000 34.316  0 140 SER A O   1 ? 
ATOM   933  C  CB  . SER A 1 117 ? 12.413  -13.425 7.849   1.000 31.884  0 140 SER A CB  1 ? 
ATOM   934  O  OG  . SER A 1 117 ? 11.450  -12.972 6.922   1.000 32.079  0 140 SER A OG  1 ? 
ATOM   935  N  N   . ALA A 1 118 ? 12.958  -15.291 5.151   1.000 27.679  0 141 ALA A N   1 ? 
ATOM   936  C  CA  . ALA A 1 118 ? 12.451  -16.467 4.470   1.000 26.123  0 141 ALA A CA  1 ? 
ATOM   937  C  C   . ALA A 1 118 ? 13.576  -17.428 4.103   1.000 28.679  0 141 ALA A C   1 ? 
ATOM   938  O  O   . ALA A 1 118 ? 13.295  -18.622 4.046   1.000 26.821  0 141 ALA A O   1 ? 
ATOM   939  C  CB  . ALA A 1 118 ? 11.694  -16.069 3.244   1.000 26.313  0 141 ALA A CB  1 ? 
ATOM   940  N  N   . TYR A 1 119 ? 14.791  -16.943 3.745   1.000 25.058  0 142 TYR A N   1 ? 
ATOM   941  C  CA  . TYR A 1 119 ? 15.743  -17.817 3.044   1.000 24.521  0 142 TYR A CA  1 ? 
ATOM   942  C  C   . TYR A 1 119 ? 17.065  -17.983 3.780   1.000 28.493  0 142 TYR A C   1 ? 
ATOM   943  O  O   . TYR A 1 119 ? 17.901  -18.802 3.412   1.000 27.311  0 142 TYR A O   1 ? 
ATOM   944  C  CB  . TYR A 1 119 ? 16.007  -17.377 1.602   1.000 24.202  0 142 TYR A CB  1 ? 
ATOM   945  C  CG  . TYR A 1 119 ? 14.692  -17.334 0.860   1.000 21.478  0 142 TYR A CG  1 ? 
ATOM   946  C  CD1 . TYR A 1 119 ? 13.843  -18.437 0.823   1.000 25.517  0 142 TYR A CD1 1 ? 
ATOM   947  C  CD2 . TYR A 1 119 ? 14.251  -16.158 0.276   1.000 22.174  0 142 TYR A CD2 1 ? 
ATOM   948  C  CE1 . TYR A 1 119 ? 12.633  -18.350 0.165   1.000 29.987  0 142 TYR A CE1 1 ? 
ATOM   949  C  CE2 . TYR A 1 119 ? 13.021  -16.043 -0.342  1.000 25.038  0 142 TYR A CE2 1 ? 
ATOM   950  C  CZ  . TYR A 1 119 ? 12.203  -17.147 -0.399  1.000 24.618  0 142 TYR A CZ  1 ? 
ATOM   951  O  OH  . TYR A 1 119 ? 10.981  -17.048 -0.994  1.000 24.159  0 142 TYR A OH  1 ? 
ATOM   952  N  N   . GLY A 1 120 ? 17.280  -17.193 4.823   1.000 30.562  0 143 GLY A N   1 ? 
ATOM   953  C  CA  . GLY A 1 120 ? 18.463  -17.401 5.623   1.000 30.634  0 143 GLY A CA  1 ? 
ATOM   954  C  C   . GLY A 1 120 ? 18.182  -17.205 7.100   1.000 31.921  0 143 GLY A C   1 ? 
ATOM   955  O  O   . GLY A 1 120 ? 17.036  -17.265 7.528   1.000 29.467  0 143 GLY A O   1 ? 
ATOM   956  N  N   . ASP A 1 121 ? 19.246  -16.951 7.876   1.000 34.559  0 144 ASP A N   1 ? 
ATOM   957  C  CA  . ASP A 1 121 ? 19.021  -16.756 9.300   1.000 31.311  0 144 ASP A CA  1 ? 
ATOM   958  C  C   . ASP A 1 121 ? 19.470  -15.379 9.793   1.000 29.983  0 144 ASP A C   1 ? 
ATOM   959  O  O   . ASP A 1 121 ? 19.644  -15.204 10.999  1.000 32.014  0 144 ASP A O   1 ? 
ATOM   960  C  CB  . ASP A 1 121 ? 19.659  -17.893 10.097  1.000 34.922  0 144 ASP A CB  1 ? 
ATOM   961  C  CG  . ASP A 1 121 ? 21.170  -17.895 10.180  1.000 37.867  0 144 ASP A CG  1 ? 
ATOM   962  O  OD1 . ASP A 1 121 ? 21.832  -16.900 9.708   1.000 39.218  0 144 ASP A OD1 1 ? 
ATOM   963  O  OD2 . ASP A 1 121 ? 21.688  -18.889 10.743  1.000 39.160  0 144 ASP A OD2 1 ? 
ATOM   964  N  N   . GLY A 1 122 ? 19.630  -14.395 8.911   1.000 28.799  0 145 GLY A N   1 ? 
ATOM   965  C  CA  . GLY A 1 122 ? 20.107  -13.072 9.284   1.000 31.085  0 145 GLY A CA  1 ? 
ATOM   966  C  C   . GLY A 1 122 ? 21.633  -12.963 9.462   1.000 30.676  0 145 GLY A C   1 ? 
ATOM   967  O  O   . GLY A 1 122 ? 22.129  -11.863 9.709   1.000 31.573  0 145 GLY A O   1 ? 
ATOM   968  N  N   . THR A 1 123 ? 22.399  -14.054 9.304   1.000 25.774  0 146 THR A N   1 ? 
ATOM   969  C  CA  . THR A 1 123 ? 23.854  -13.998 9.453   1.000 28.263  0 146 THR A CA  1 ? 
ATOM   970  C  C   . THR A 1 123 ? 24.563  -14.266 8.127   1.000 24.742  0 146 THR A C   1 ? 
ATOM   971  O  O   . THR A 1 123 ? 23.978  -14.901 7.269   1.000 24.937  0 146 THR A O   1 ? 
ATOM   972  C  CB  . THR A 1 123 ? 24.351  -15.002 10.503  1.000 31.693  0 146 THR A CB  1 ? 
ATOM   973  O  OG1 . THR A 1 123 ? 24.338  -16.327 9.959   1.000 30.209  0 146 THR A OG1 1 ? 
ATOM   974  C  CG2 . THR A 1 123 ? 23.532  -14.954 11.777  1.000 33.049  0 146 THR A CG2 1 ? 
ATOM   975  N  N   . GLN A 1 124 ? 25.797  -13.768 7.962   1.000 25.355  0 147 GLN A N   1 ? 
ATOM   976  C  CA  . GLN A 1 124 ? 26.513  -13.916 6.700   1.000 25.541  0 147 GLN A CA  1 ? 
ATOM   977  C  C   . GLN A 1 124 ? 26.935  -15.372 6.514   1.000 25.166  0 147 GLN A C   1 ? 
ATOM   978  O  O   . GLN A 1 124 ? 27.058  -15.821 5.391   1.000 23.720  0 147 GLN A O   1 ? 
ATOM   979  C  CB  . GLN A 1 124 ? 27.720  -12.976 6.546   1.000 30.771  0 147 GLN A CB  1 ? 
ATOM   980  C  CG  . GLN A 1 124 ? 28.989  -13.386 7.283   1.000 31.890  0 147 GLN A CG  1 ? 
ATOM   981  C  CD  . GLN A 1 124 ? 30.070  -12.336 7.141   1.000 33.261  0 147 GLN A CD  1 ? 
ATOM   982  O  OE1 . GLN A 1 124 ? 29.860  -11.214 6.658   1.000 30.531  0 147 GLN A OE1 1 ? 
ATOM   983  N  NE2 . GLN A 1 124 ? 31.264  -12.726 7.544   1.000 26.288  0 147 GLN A NE2 1 ? 
ATOM   984  N  N   . GLU A 1 125 ? 27.086  -16.101 7.608   1.000 23.239  0 148 GLU A N   1 ? 
ATOM   985  C  CA  . GLU A 1 125 ? 27.698  -17.433 7.531   1.000 25.624  0 148 GLU A CA  1 ? 
ATOM   986  C  C   . GLU A 1 125 ? 26.693  -18.529 7.129   1.000 26.419  0 148 GLU A C   1 ? 
ATOM   987  O  O   . GLU A 1 125 ? 27.129  -19.546 6.626   1.000 25.898  0 148 GLU A O   1 ? 
ATOM   988  C  CB  . GLU A 1 125 ? 28.496  -17.824 8.783   1.000 32.979  0 148 GLU A CB  1 ? 
ATOM   989  C  CG  . GLU A 1 125 ? 28.064  -17.277 10.118  1.000 43.697  0 148 GLU A CG  1 ? 
ATOM   990  C  CD  . GLU A 1 125 ? 28.324  -15.799 10.396  1.000 39.514  0 148 GLU A CD  1 ? 
ATOM   991  O  OE1 . GLU A 1 125 ? 27.332  -15.126 10.387  1.000 44.590  0 148 GLU A OE1 1 ? 
ATOM   992  O  OE2 . GLU A 1 125 ? 29.519  -15.316 10.687  1.000 44.218  0 148 GLU A OE2 1 ? 
ATOM   993  N  N   . THR A 1 126 ? 25.391  -18.361 7.344   1.000 25.475  0 149 THR A N   1 ? 
ATOM   994  C  CA  . THR A 1 126 ? 24.385  -19.345 6.927   1.000 27.580  0 149 THR A CA  1 ? 
ATOM   995  C  C   . THR A 1 126 ? 23.918  -19.025 5.505   1.000 28.546  0 149 THR A C   1 ? 
ATOM   996  O  O   . THR A 1 126 ? 23.127  -18.118 5.262   1.000 25.690  0 149 THR A O   1 ? 
ATOM   997  C  CB  . THR A 1 126 ? 23.203  -19.357 7.889   1.000 31.381  0 149 THR A CB  1 ? 
ATOM   998  O  OG1 . THR A 1 126 ? 23.771  -19.582 9.177   1.000 32.057  0 149 THR A OG1 1 ? 
ATOM   999  C  CG2 . THR A 1 126 ? 22.156  -20.406 7.577   1.000 30.761  0 149 THR A CG2 1 ? 
ATOM   1000 N  N   . ILE A 1 127 ? 24.367  -19.829 4.566   1.000 25.597  0 150 ILE A N   1 ? 
ATOM   1001 C  CA  . ILE A 1 127 ? 24.118  -19.569 3.151   1.000 27.358  0 150 ILE A CA  1 ? 
ATOM   1002 C  C   . ILE A 1 127 ? 22.625  -19.559 2.878   1.000 23.937  0 150 ILE A C   1 ? 
ATOM   1003 O  O   . ILE A 1 127 ? 21.895  -20.491 3.252   1.000 23.927  0 150 ILE A O   1 ? 
ATOM   1004 C  CB  . ILE A 1 127 ? 24.819  -20.630 2.283   1.000 28.685  0 150 ILE A CB  1 ? 
ATOM   1005 C  CG1 . ILE A 1 127 ? 26.313  -20.737 2.589   1.000 35.670  0 150 ILE A CG1 1 ? 
ATOM   1006 C  CG2 . ILE A 1 127 ? 24.521  -20.375 0.817   1.000 31.152  0 150 ILE A CG2 1 ? 
ATOM   1007 C  CD1 . ILE A 1 127 ? 27.059  -19.443 2.434   1.000 35.178  0 150 ILE A CD1 1 ? 
ATOM   1008 N  N   . ALA A 1 128 ? 22.134  -18.489 2.233   1.000 24.169  0 151 ALA A N   1 ? 
ATOM   1009 C  CA  . ALA A 1 128 ? 20.716  -18.422 1.904   1.000 22.234  0 151 ALA A CA  1 ? 
ATOM   1010 C  C   . ALA A 1 128 ? 20.403  -19.323 0.735   1.000 21.778  0 151 ALA A C   1 ? 
ATOM   1011 O  O   . ALA A 1 128 ? 21.167  -19.368 -0.226  1.000 23.224  0 151 ALA A O   1 ? 
ATOM   1012 C  CB  . ALA A 1 128 ? 20.239  -17.036 1.582   1.000 25.418  0 151 ALA A CB  1 ? 
ATOM   1013 N  N   . VAL A 1 129 ? 19.252  -19.976 0.832   1.000 22.172  0 152 VAL A N   1 ? 
ATOM   1014 C  CA  . VAL A 1 129 ? 18.758  -20.855 -0.210  1.000 20.785  0 152 VAL A CA  1 ? 
ATOM   1015 C  C   . VAL A 1 129 ? 17.350  -20.406 -0.539  1.000 22.115  0 152 VAL A C   1 ? 
ATOM   1016 O  O   . VAL A 1 129 ? 16.467  -20.449 0.311   1.000 21.962  0 152 VAL A O   1 ? 
ATOM   1017 C  CB  . VAL A 1 129 ? 18.795  -22.328 0.220   1.000 25.124  0 152 VAL A CB  1 ? 
ATOM   1018 C  CG1 . VAL A 1 129 ? 18.242  -23.226 -0.870  1.000 26.625  0 152 VAL A CG1 1 ? 
ATOM   1019 C  CG2 . VAL A 1 129 ? 20.180  -22.772 0.657   1.000 27.752  0 152 VAL A CG2 1 ? 
ATOM   1020 N  N   . PHE A 1 130 ? 17.137  -20.058 -1.806  1.000 20.906  0 153 PHE A N   1 ? 
ATOM   1021 C  CA  . PHE A 1 130 ? 15.843  -19.661 -2.316  1.000 21.513  0 153 PHE A CA  1 ? 
ATOM   1022 C  C   . PHE A 1 130 ? 15.103  -20.909 -2.760  1.000 23.682  0 153 PHE A C   1 ? 
ATOM   1023 O  O   . PHE A 1 130 ? 15.674  -21.712 -3.504  1.000 25.484  0 153 PHE A O   1 ? 
ATOM   1024 C  CB  . PHE A 1 130 ? 15.998  -18.745 -3.534  1.000 23.809  0 153 PHE A CB  1 ? 
ATOM   1025 C  CG  . PHE A 1 130 ? 16.741  -17.496 -3.194  1.000 23.357  0 153 PHE A CG  1 ? 
ATOM   1026 C  CD1 . PHE A 1 130 ? 16.063  -16.406 -2.688  1.000 25.821  0 153 PHE A CD1 1 ? 
ATOM   1027 C  CD2 . PHE A 1 130 ? 18.104  -17.408 -3.389  1.000 27.250  0 153 PHE A CD2 1 ? 
ATOM   1028 C  CE1 . PHE A 1 130 ? 16.761  -15.271 -2.313  1.000 29.763  0 153 PHE A CE1 1 ? 
ATOM   1029 C  CE2 . PHE A 1 130 ? 18.789  -16.256 -3.036  1.000 31.634  0 153 PHE A CE2 1 ? 
ATOM   1030 C  CZ  . PHE A 1 130 ? 18.111  -15.197 -2.494  1.000 27.915  0 153 PHE A CZ  1 ? 
ATOM   1031 N  N   . LYS A 1 131 ? 13.863  -21.065 -2.285  1.000 21.872  0 154 LYS A N   1 ? 
ATOM   1032 C  CA  . LYS A 1 131 ? 13.063  -22.222 -2.704  1.000 25.720  0 154 LYS A CA  1 ? 
ATOM   1033 C  C   . LYS A 1 131 ? 11.603  -21.933 -2.392  1.000 27.534  0 154 LYS A C   1 ? 
ATOM   1034 O  O   . LYS A 1 131 ? 11.298  -21.094 -1.534  1.000 23.689  0 154 LYS A O   1 ? 
ATOM   1035 C  CB  . LYS A 1 131 ? 13.590  -23.472 -2.000  1.000 31.013  0 154 LYS A CB  1 ? 
ATOM   1036 C  CG  . LYS A 1 131 ? 13.452  -23.467 -0.487  1.000 36.887  0 154 LYS A CG  1 ? 
ATOM   1037 C  CD  . LYS A 1 131 ? 14.129  -24.667 0.152   1.000 48.449  0 154 LYS A CD  1 ? 
ATOM   1038 C  CE  . LYS A 1 131 ? 13.882  -24.743 1.640   1.000 57.706  0 154 LYS A CE  1 ? 
ATOM   1039 N  NZ  . LYS A 1 131 ? 14.489  -25.971 2.205   1.000 67.106  0 154 LYS A NZ  1 ? 
ATOM   1040 N  N   . PRO A 1 132 ? 10.632  -22.518 -3.122  1.000 26.692  0 155 PRO A N   1 ? 
ATOM   1041 C  CA  . PRO A 1 132 ? 10.904  -23.404 -4.253  1.000 27.335  0 155 PRO A CA  1 ? 
ATOM   1042 C  C   . PRO A 1 132 ? 11.084  -22.609 -5.545  1.000 27.048  0 155 PRO A C   1 ? 
ATOM   1043 O  O   . PRO A 1 132 ? 10.381  -21.612 -5.780  1.000 24.846  0 155 PRO A O   1 ? 
ATOM   1044 C  CB  . PRO A 1 132 ? 9.622   -24.253 -4.305  1.000 26.015  0 155 PRO A CB  1 ? 
ATOM   1045 C  CG  . PRO A 1 132 ? 8.546   -23.251 -3.917  1.000 27.815  0 155 PRO A CG  1 ? 
ATOM   1046 C  CD  . PRO A 1 132 ? 9.190   -22.397 -2.834  1.000 27.192  0 155 PRO A CD  1 ? 
ATOM   1047 N  N   . VAL A 1 133 ? 11.980  -23.107 -6.392  1.000 25.001  0 156 VAL A N   1 ? 
ATOM   1048 C  CA  . VAL A 1 133 ? 12.191  -22.511 -7.708  1.000 24.756  0 156 VAL A CA  1 ? 
ATOM   1049 C  C   . VAL A 1 133 ? 11.997  -23.578 -8.777  1.000 26.020  0 156 VAL A C   1 ? 
ATOM   1050 O  O   . VAL A 1 133 ? 12.724  -24.549 -8.781  1.000 28.013  0 156 VAL A O   1 ? 
ATOM   1051 C  CB  . VAL A 1 133 ? 13.589  -21.907 -7.875  1.000 25.915  0 156 VAL A CB  1 ? 
ATOM   1052 C  CG1 . VAL A 1 133 ? 13.710  -21.323 -9.259  1.000 27.683  0 156 VAL A CG1 1 ? 
ATOM   1053 C  CG2 . VAL A 1 133 ? 13.863  -20.852 -6.818  1.000 27.026  0 156 VAL A CG2 1 ? 
ATOM   1054 N  N   . ASP A 1 134 ? 11.093  -23.314 -9.708  1.000 28.162  0 157 ASP A N   1 ? 
ATOM   1055 C  CA  . ASP A 1 134 ? 10.796  -24.202 -10.822 1.000 28.474  0 157 ASP A CA  1 ? 
ATOM   1056 C  C   . ASP A 1 134 ? 11.454  -23.636 -12.081 1.000 25.657  0 157 ASP A C   1 ? 
ATOM   1057 O  O   . ASP A 1 134 ? 11.073  -22.560 -12.517 1.000 26.415  0 157 ASP A O   1 ? 
ATOM   1058 C  CB  . ASP A 1 134 ? 9.277   -24.268 -11.002 1.000 30.412  0 157 ASP A CB  1 ? 
ATOM   1059 C  CG  . ASP A 1 134 ? 8.781   -25.260 -12.046 1.000 42.043  0 157 ASP A CG  1 ? 
ATOM   1060 O  OD1 . ASP A 1 134 ? 9.627   -25.944 -12.682 1.000 32.576  0 157 ASP A OD1 1 ? 
ATOM   1061 O  OD2 . ASP A 1 134 ? 7.554   -25.281 -12.260 1.000 40.149  0 157 ASP A OD2 1 ? 
ATOM   1062 N  N   . TYR A 1 135 ? 12.438  -24.365 -12.629 1.000 23.744  0 158 TYR A N   1 ? 
ATOM   1063 C  CA  . TYR A 1 135 ? 13.122  -23.961 -13.849 1.000 26.670  0 158 TYR A CA  1 ? 
ATOM   1064 C  C   . TYR A 1 135 ? 12.516  -24.553 -15.114 1.000 29.194  0 158 TYR A C   1 ? 
ATOM   1065 O  O   . TYR A 1 135 ? 13.083  -24.363 -16.185 1.000 27.580  0 158 TYR A O   1 ? 
ATOM   1066 C  CB  . TYR A 1 135 ? 14.590  -24.376 -13.802 1.000 26.683  0 158 TYR A CB  1 ? 
ATOM   1067 C  CG  . TYR A 1 135 ? 15.387  -23.714 -12.687 1.000 25.145  0 158 TYR A CG  1 ? 
ATOM   1068 C  CD1 . TYR A 1 135 ? 15.984  -22.459 -12.852 1.000 25.061  0 158 TYR A CD1 1 ? 
ATOM   1069 C  CD2 . TYR A 1 135 ? 15.519  -24.333 -11.450 1.000 25.073  0 158 TYR A CD2 1 ? 
ATOM   1070 C  CE1 . TYR A 1 135 ? 16.709  -21.871 -11.825 1.000 24.715  0 158 TYR A CE1 1 ? 
ATOM   1071 C  CE2 . TYR A 1 135 ? 16.226  -23.739 -10.409 1.000 26.367  0 158 TYR A CE2 1 ? 
ATOM   1072 C  CZ  . TYR A 1 135 ? 16.810  -22.494 -10.595 1.000 26.751  0 158 TYR A CZ  1 ? 
ATOM   1073 O  OH  . TYR A 1 135 ? 17.542  -21.907 -9.620  1.000 25.901  0 158 TYR A OH  1 ? 
ATOM   1074 N  N   . SER A 1 136 ? 11.368  -25.230 -15.010 1.000 28.257  0 159 SER A N   1 ? 
ATOM   1075 C  CA  . SER A 1 136 ? 10.897  -26.012 -16.135 1.000 31.567  0 159 SER A CA  1 ? 
ATOM   1076 C  C   . SER A 1 136 ? 10.379  -25.133 -17.274 1.000 33.490  0 159 SER A C   1 ? 
ATOM   1077 O  O   . SER A 1 136 ? 10.379  -25.582 -18.413 1.000 33.129  0 159 SER A O   1 ? 
ATOM   1078 C  CB  . SER A 1 136 ? 9.921   -27.056 -15.678 1.000 34.272  0 159 SER A CB  1 ? 
ATOM   1079 O  OG  . SER A 1 136 ? 8.728   -26.453 -15.229 1.000 35.101  0 159 SER A OG  1 ? 
ATOM   1080 N  N   . SER A 1 137 ? 10.087  -23.844 -17.025 1.000 31.590  0 160 SER A N   1 ? 
ATOM   1081 C  CA  . SER A 1 137 ? 9.625   -22.952 -18.071 1.000 32.512  0 160 SER A CA  1 ? 
ATOM   1082 C  C   . SER A 1 137 ? 10.740  -22.443 -18.973 1.000 34.851  0 160 SER A C   1 ? 
ATOM   1083 O  O   . SER A 1 137 ? 10.453  -21.711 -19.907 1.000 40.210  0 160 SER A O   1 ? 
ATOM   1084 C  CB  . SER A 1 137 ? 8.900   -21.759 -17.507 1.000 36.902  0 160 SER A CB  1 ? 
ATOM   1085 O  OG  . SER A 1 137 ? 9.793   -20.859 -16.830 1.000 34.624  0 160 SER A OG  1 ? 
ATOM   1086 N  N   A CYS A 1 138 ? 12.002  -22.759 -18.661 0.500 36.441  0 161 CYS A N   1 ? 
ATOM   1087 N  N   B CYS A 1 138 ? 11.993  -22.775 -18.663 0.500 37.104  0 161 CYS A N   1 ? 
ATOM   1088 C  CA  A CYS A 1 138 ? 13.106  -22.223 -19.435 0.500 39.083  0 161 CYS A CA  1 ? 
ATOM   1089 C  CA  B CYS A 1 138 ? 13.100  -22.278 -19.452 0.500 40.211  0 161 CYS A CA  1 ? 
ATOM   1090 C  C   A CYS A 1 138 ? 12.974  -22.724 -20.871 0.500 43.104  0 161 CYS A C   1 ? 
ATOM   1091 C  C   B CYS A 1 138 ? 12.927  -22.743 -20.891 0.500 43.436  0 161 CYS A C   1 ? 
ATOM   1092 O  O   A CYS A 1 138 ? 12.901  -23.930 -21.092 0.500 45.505  0 161 CYS A O   1 ? 
ATOM   1093 O  O   B CYS A 1 138 ? 12.769  -23.936 -21.133 0.500 45.134  0 161 CYS A O   1 ? 
ATOM   1094 C  CB  A CYS A 1 138 ? 14.443  -22.609 -18.818 0.500 38.379  0 161 CYS A CB  1 ? 
ATOM   1095 C  CB  B CYS A 1 138 ? 14.411  -22.737 -18.842 0.500 40.318  0 161 CYS A CB  1 ? 
ATOM   1096 S  SG  A CYS A 1 138 ? 15.844  -21.711 -19.537 0.500 36.098  0 161 CYS A SG  1 ? 
ATOM   1097 S  SG  B CYS A 1 138 ? 14.754  -21.855 -17.302 0.500 41.831  0 161 CYS A SG  1 ? 
ATOM   1098 N  N   . ALA A 1 139 ? 12.900  -21.788 -21.827 1.000 42.794  0 162 ALA A N   1 ? 
ATOM   1099 C  CA  . ALA A 1 139 ? 12.759  -22.129 -23.235 1.000 46.299  0 162 ALA A CA  1 ? 
ATOM   1100 C  C   . ALA A 1 139 ? 13.894  -23.063 -23.666 1.000 46.052  0 162 ALA A C   1 ? 
ATOM   1101 O  O   . ALA A 1 139 ? 15.023  -22.987 -23.161 1.000 39.613  0 162 ALA A O   1 ? 
ATOM   1102 C  CB  . ALA A 1 139 ? 12.722  -20.866 -24.056 1.000 49.049  0 162 ALA A CB  1 ? 
ATOM   1103 N  N   . SER A 1 140 ? 13.618  -23.982 -24.601 1.000 46.981  0 163 SER A N   1 ? 
ATOM   1104 C  CA  . SER A 1 140 ? 14.736  -24.698 -25.195 1.000 51.068  0 163 SER A CA  1 ? 
ATOM   1105 C  C   . SER A 1 140 ? 15.567  -23.657 -25.946 1.000 46.977  0 163 SER A C   1 ? 
ATOM   1106 O  O   . SER A 1 140 ? 15.046  -22.670 -26.463 1.000 52.389  0 163 SER A O   1 ? 
ATOM   1107 C  CB  . SER A 1 140 ? 14.284  -25.837 -26.081 1.000 60.700  0 163 SER A CB  1 ? 
ATOM   1108 O  OG  . SER A 1 140 ? 13.726  -25.343 -27.295 1.000 64.974  0 163 SER A OG  1 ? 
ATOM   1109 N  N   . GLY A 1 141 ? 16.882  -23.779 -25.930 1.000 53.566  0 164 GLY A N   1 ? 
ATOM   1110 C  CA  . GLY A 1 141 ? 17.670  -22.699 -26.513 1.000 51.494  0 164 GLY A CA  1 ? 
ATOM   1111 C  C   . GLY A 1 141 ? 17.936  -21.542 -25.547 1.000 52.929  0 164 GLY A C   1 ? 
ATOM   1112 O  O   . GLY A 1 141 ? 18.664  -20.622 -25.916 1.000 46.887  0 164 GLY A O   1 ? 
ATOM   1113 N  N   . GLY A 1 142 ? 17.349  -21.575 -24.334 1.000 38.351  0 165 GLY A N   1 ? 
ATOM   1114 C  CA  . GLY A 1 142 ? 17.863  -20.781 -23.223 1.000 40.022  0 165 GLY A CA  1 ? 
ATOM   1115 C  C   . GLY A 1 142 ? 16.863  -19.763 -22.668 1.000 35.949  0 165 GLY A C   1 ? 
ATOM   1116 O  O   . GLY A 1 142 ? 15.913  -19.365 -23.331 1.000 37.702  0 165 GLY A O   1 ? 
ATOM   1117 N  N   A CYS A 1 143 ? 17.073  -19.368 -21.407 0.500 36.558  0 166 CYS A N   1 ? 
ATOM   1118 N  N   B CYS A 1 143 ? 17.090  -19.335 -21.420 0.500 37.008  0 166 CYS A N   1 ? 
ATOM   1119 C  CA  A CYS A 1 143 ? 16.335  -18.263 -20.813 0.500 33.237  0 166 CYS A CA  1 ? 
ATOM   1120 C  CA  B CYS A 1 143 ? 16.328  -18.230 -20.859 0.500 34.148  0 166 CYS A CA  1 ? 
ATOM   1121 C  C   A CYS A 1 143 ? 17.327  -17.372 -20.072 0.500 28.532  0 166 CYS A C   1 ? 
ATOM   1122 C  C   B CYS A 1 143 ? 17.188  -17.514 -19.823 0.500 29.801  0 166 CYS A C   1 ? 
ATOM   1123 O  O   A CYS A 1 143 ? 18.531  -17.627 -20.077 0.500 26.026  0 166 CYS A O   1 ? 
ATOM   1124 O  O   B CYS A 1 143 ? 18.151  -18.069 -19.312 0.500 30.049  0 166 CYS A O   1 ? 
ATOM   1125 C  CB  A CYS A 1 143 ? 15.225  -18.754 -19.892 0.500 34.044  0 166 CYS A CB  1 ? 
ATOM   1126 C  CB  B CYS A 1 143 ? 15.006  -18.703 -20.268 0.500 35.575  0 166 CYS A CB  1 ? 
ATOM   1127 S  SG  A CYS A 1 143 ? 15.812  -19.872 -18.596 0.500 45.423  0 166 CYS A SG  1 ? 
ATOM   1128 S  SG  B CYS A 1 143 ? 15.030  -18.948 -18.479 0.500 42.622  0 166 CYS A SG  1 ? 
ATOM   1129 N  N   . MET A 1 144 ? 16.821  -16.276 -19.513 1.000 28.149  0 167 MET A N   1 ? 
ATOM   1130 C  CA  . MET A 1 144 ? 17.627  -15.455 -18.639 1.000 23.907  0 167 MET A CA  1 ? 
ATOM   1131 C  C   . MET A 1 144 ? 16.993  -15.471 -17.241 1.000 21.980  0 167 MET A C   1 ? 
ATOM   1132 O  O   . MET A 1 144 ? 15.844  -15.070 -17.097 1.000 24.398  0 167 MET A O   1 ? 
ATOM   1133 C  CB  . MET A 1 144 ? 17.661  -14.036 -19.193 1.000 26.170  0 167 MET A CB  1 ? 
ATOM   1134 C  CG  . MET A 1 144 ? 18.585  -13.130 -18.430 1.000 28.111  0 167 MET A CG  1 ? 
ATOM   1135 S  SD  . MET A 1 144 ? 20.318  -13.487 -18.651 1.000 31.220  0 167 MET A SD  1 ? 
ATOM   1136 C  CE  . MET A 1 144 ? 20.461  -13.215 -20.428 1.000 32.094  0 167 MET A CE  1 ? 
ATOM   1137 N  N   . LEU A 1 145 ? 17.753  -15.889 -16.232 1.000 21.356  0 168 LEU A N   1 ? 
ATOM   1138 C  CA  . LEU A 1 145 ? 17.347  -15.696 -14.842 1.000 22.643  0 168 LEU A CA  1 ? 
ATOM   1139 C  C   . LEU A 1 145 ? 17.690  -14.276 -14.429 1.000 22.307  0 168 LEU A C   1 ? 
ATOM   1140 O  O   . LEU A 1 145 ? 18.797  -13.817 -14.707 1.000 21.198  0 168 LEU A O   1 ? 
ATOM   1141 C  CB  . LEU A 1 145 ? 18.037  -16.700 -13.936 1.000 22.362  0 168 LEU A CB  1 ? 
ATOM   1142 C  CG  . LEU A 1 145 ? 17.696  -16.583 -12.447 1.000 25.756  0 168 LEU A CG  1 ? 
ATOM   1143 C  CD1 . LEU A 1 145 ? 17.793  -17.932 -11.804 1.000 24.636  0 168 LEU A CD1 1 ? 
ATOM   1144 C  CD2 . LEU A 1 145 ? 18.655  -15.634 -11.718 1.000 28.226  0 168 LEU A CD2 1 ? 
ATOM   1145 N  N   . ARG A 1 146 ? 16.739  -13.596 -13.774 1.000 22.119  0 169 ARG A N   1 ? 
ATOM   1146 C  CA  . ARG A 1 146 ? 17.012  -12.293 -13.185 1.000 21.797  0 169 ARG A CA  1 ? 
ATOM   1147 C  C   . ARG A 1 146 ? 16.611  -12.309 -11.724 1.000 20.152  0 169 ARG A C   1 ? 
ATOM   1148 O  O   . ARG A 1 146 ? 15.542  -12.807 -11.366 1.000 22.783  0 169 ARG A O   1 ? 
ATOM   1149 C  CB  . ARG A 1 146 ? 16.260  -11.196 -13.921 1.000 25.304  0 169 ARG A CB  1 ? 
ATOM   1150 C  CG  . ARG A 1 146 ? 16.809  -10.932 -15.316 1.000 26.211  0 169 ARG A CG  1 ? 
ATOM   1151 C  CD  . ARG A 1 146 ? 15.962  -9.864  -15.960 1.000 24.245  0 169 ARG A CD  1 ? 
ATOM   1152 N  NE  . ARG A 1 146 ? 16.489  -9.469  -17.240 1.000 27.314  0 169 ARG A NE  1 ? 
ATOM   1153 C  CZ  . ARG A 1 146 ? 16.221  -10.063 -18.401 1.000 31.700  0 169 ARG A CZ  1 ? 
ATOM   1154 N  NH1 . ARG A 1 146 ? 15.373  -11.073 -18.497 1.000 28.302  0 169 ARG A NH1 1 ? 
ATOM   1155 N  NH2 . ARG A 1 146 ? 16.792  -9.609  -19.500 1.000 31.065  0 169 ARG A NH2 1 ? 
ATOM   1156 N  N   . PHE A 1 147 ? 17.527  -11.806 -10.902 1.000 18.485  0 170 PHE A N   1 ? 
ATOM   1157 C  CA  . PHE A 1 147 ? 17.323  -11.638 -9.489  1.000 17.533  0 170 PHE A CA  1 ? 
ATOM   1158 C  C   . PHE A 1 147 ? 17.240  -10.152 -9.175  1.000 18.186  0 170 PHE A C   1 ? 
ATOM   1159 O  O   . PHE A 1 147 ? 18.065  -9.369  -9.675  1.000 19.144  0 170 PHE A O   1 ? 
ATOM   1160 C  CB  . PHE A 1 147 ? 18.515  -12.206 -8.743  1.000 18.476  0 170 PHE A CB  1 ? 
ATOM   1161 C  CG  . PHE A 1 147 ? 18.518  -12.001 -7.243  1.000 20.592  0 170 PHE A CG  1 ? 
ATOM   1162 C  CD1 . PHE A 1 147 ? 17.593  -12.643 -6.454  1.000 21.000  0 170 PHE A CD1 1 ? 
ATOM   1163 C  CD2 . PHE A 1 147 ? 19.439  -11.143 -6.645  1.000 21.692  0 170 PHE A CD2 1 ? 
ATOM   1164 C  CE1 . PHE A 1 147 ? 17.580  -12.445 -5.076  1.000 24.123  0 170 PHE A CE1 1 ? 
ATOM   1165 C  CE2 . PHE A 1 147 ? 19.466  -11.000 -5.264  1.000 23.602  0 170 PHE A CE2 1 ? 
ATOM   1166 C  CZ  . PHE A 1 147 ? 18.521  -11.645 -4.498  1.000 22.364  0 170 PHE A CZ  1 ? 
ATOM   1167 N  N   . TYR A 1 148 ? 16.263  -9.806  -8.326  1.000 18.881  0 171 TYR A N   1 ? 
ATOM   1168 C  CA  . TYR A 1 148 ? 16.044  -8.433  -7.892  1.000 18.528  0 171 TYR A CA  1 ? 
ATOM   1169 C  C   . TYR A 1 148 ? 15.883  -8.453  -6.376  1.000 18.292  0 171 TYR A C   1 ? 
ATOM   1170 O  O   . TYR A 1 148 ? 15.097  -9.238  -5.833  1.000 19.347  0 171 TYR A O   1 ? 
ATOM   1171 C  CB  . TYR A 1 148 ? 14.848  -7.705  -8.507  1.000 18.835  0 171 TYR A CB  1 ? 
ATOM   1172 C  CG  . TYR A 1 148 ? 14.875  -7.532  -10.013 1.000 20.849  0 171 TYR A CG  1 ? 
ATOM   1173 C  CD1 . TYR A 1 148 ? 14.526  -8.578  -10.848 1.000 23.059  0 171 TYR A CD1 1 ? 
ATOM   1174 C  CD2 . TYR A 1 148 ? 15.224  -6.323  -10.598 1.000 22.577  0 171 TYR A CD2 1 ? 
ATOM   1175 C  CE1 . TYR A 1 148 ? 14.533  -8.437  -12.214 1.000 23.040  0 171 TYR A CE1 1 ? 
ATOM   1176 C  CE2 . TYR A 1 148 ? 15.262  -6.173  -11.966 1.000 23.657  0 171 TYR A CE2 1 ? 
ATOM   1177 C  CZ  . TYR A 1 148 ? 14.889  -7.226  -12.784 1.000 23.620  0 171 TYR A CZ  1 ? 
ATOM   1178 O  OH  . TYR A 1 148 ? 14.873  -7.102  -14.153 1.000 24.869  0 171 TYR A OH  1 ? 
ATOM   1179 N  N   . TRP A 1 149 ? 16.626  -7.573  -5.715  1.000 18.431  0 172 TRP A N   1 ? 
ATOM   1180 C  CA  . TRP A 1 149 ? 16.497  -7.395  -4.270  1.000 18.271  0 172 TRP A CA  1 ? 
ATOM   1181 C  C   . TRP A 1 149 ? 16.595  -5.927  -3.883  1.000 19.875  0 172 TRP A C   1 ? 
ATOM   1182 O  O   . TRP A 1 149 ? 17.537  -5.250  -4.282  1.000 18.552  0 172 TRP A O   1 ? 
ATOM   1183 C  CB  . TRP A 1 149 ? 17.614  -8.194  -3.608  1.000 18.716  0 172 TRP A CB  1 ? 
ATOM   1184 C  CG  . TRP A 1 149 ? 17.699  -8.144  -2.120  1.000 18.007  0 172 TRP A CG  1 ? 
ATOM   1185 C  CD1 . TRP A 1 149 ? 16.696  -7.965  -1.214  1.000 21.327  0 172 TRP A CD1 1 ? 
ATOM   1186 C  CD2 . TRP A 1 149 ? 18.909  -8.358  -1.349  1.000 19.899  0 172 TRP A CD2 1 ? 
ATOM   1187 N  NE1 . TRP A 1 149 ? 17.215  -7.979  0.066   1.000 20.928  0 172 TRP A NE1 1 ? 
ATOM   1188 C  CE2 . TRP A 1 149 ? 18.548  -8.271  0.008   1.000 20.367  0 172 TRP A CE2 1 ? 
ATOM   1189 C  CE3 . TRP A 1 149 ? 20.243  -8.647  -1.664  1.000 19.571  0 172 TRP A CE3 1 ? 
ATOM   1190 C  CZ2 . TRP A 1 149 ? 19.491  -8.422  1.021   1.000 21.391  0 172 TRP A CZ2 1 ? 
ATOM   1191 C  CZ3 . TRP A 1 149 ? 21.160  -8.821  -0.658  1.000 21.317  0 172 TRP A CZ3 1 ? 
ATOM   1192 C  CH2 . TRP A 1 149 ? 20.787  -8.705  0.661   1.000 20.271  0 172 TRP A CH2 1 ? 
ATOM   1193 N  N   . LEU A 1 150 ? 15.552  -5.411  -3.203  1.000 18.166  0 173 LEU A N   1 ? 
ATOM   1194 C  CA  . LEU A 1 150 ? 15.587  -4.074  -2.657  1.000 18.051  0 173 LEU A CA  1 ? 
ATOM   1195 C  C   . LEU A 1 150 ? 15.860  -4.194  -1.165  1.000 18.593  0 173 LEU A C   1 ? 
ATOM   1196 O  O   . LEU A 1 150 ? 14.976  -4.554  -0.399  1.000 20.890  0 173 LEU A O   1 ? 
ATOM   1197 C  CB  . LEU A 1 150 ? 14.260  -3.392  -2.934  1.000 19.436  0 173 LEU A CB  1 ? 
ATOM   1198 C  CG  . LEU A 1 150 ? 14.205  -1.918  -2.531  1.000 23.488  0 173 LEU A CG  1 ? 
ATOM   1199 C  CD1 . LEU A 1 150 ? 15.087  -1.120  -3.442  1.000 25.518  0 173 LEU A CD1 1 ? 
ATOM   1200 C  CD2 . LEU A 1 150 ? 12.774  -1.422  -2.598  1.000 29.883  0 173 LEU A CD2 1 ? 
ATOM   1201 N  N   . ALA A 1 151 ? 17.092  -3.922  -0.787  1.000 18.752  0 174 ALA A N   1 ? 
ATOM   1202 C  CA  . ALA A 1 151 ? 17.486  -3.985  0.592   1.000 20.598  0 174 ALA A CA  1 ? 
ATOM   1203 C  C   . ALA A 1 151 ? 17.147  -2.678  1.291   1.000 21.801  0 174 ALA A C   1 ? 
ATOM   1204 O  O   . ALA A 1 151 ? 17.347  -1.601  0.734   1.000 21.089  0 174 ALA A O   1 ? 
ATOM   1205 C  CB  . ALA A 1 151 ? 18.934  -4.334  0.666   1.000 24.624  0 174 ALA A CB  1 ? 
ATOM   1206 N  N   . LEU A 1 152 ? 16.639  -2.822  2.521   1.000 22.191  0 175 LEU A N   1 ? 
ATOM   1207 C  CA  . LEU A 1 152 ? 16.277  -1.702  3.368   1.000 22.919  0 175 LEU A CA  1 ? 
ATOM   1208 C  C   . LEU A 1 152 ? 17.146  -1.775  4.616   1.000 19.950  0 175 LEU A C   1 ? 
ATOM   1209 O  O   . LEU A 1 152 ? 17.220  -2.810  5.272   1.000 23.000  0 175 LEU A O   1 ? 
ATOM   1210 C  CB  . LEU A 1 152 ? 14.813  -1.813  3.788   1.000 22.781  0 175 LEU A CB  1 ? 
ATOM   1211 C  CG  . LEU A 1 152 ? 13.811  -2.076  2.673   1.000 22.973  0 175 LEU A CG  1 ? 
ATOM   1212 C  CD1 . LEU A 1 152 ? 12.479  -2.542  3.208   1.000 25.767  0 175 LEU A CD1 1 ? 
ATOM   1213 C  CD2 . LEU A 1 152 ? 13.644  -0.866  1.796   1.000 25.342  0 175 LEU A CD2 1 ? 
ATOM   1214 N  N   . GLN A 1 153 ? 17.857  -0.673  4.895   1.000 22.593  0 176 GLN A N   1 ? 
ATOM   1215 C  CA  . GLN A 1 153 ? 18.679  -0.665  6.087   1.000 22.645  0 176 GLN A CA  1 ? 
ATOM   1216 C  C   . GLN A 1 153 ? 18.868  0.743   6.626   1.000 23.678  0 176 GLN A C   1 ? 
ATOM   1217 O  O   . GLN A 1 153 ? 18.698  1.717   5.912   1.000 22.859  0 176 GLN A O   1 ? 
ATOM   1218 C  CB  . GLN A 1 153 ? 20.025  -1.355  5.847   1.000 30.793  0 176 GLN A CB  1 ? 
ATOM   1219 C  CG  . GLN A 1 153 ? 20.865  -0.788  4.732   1.000 31.741  0 176 GLN A CG  1 ? 
ATOM   1220 C  CD  . GLN A 1 153 ? 21.993  -1.765  4.416   1.000 35.766  0 176 GLN A CD  1 ? 
ATOM   1221 O  OE1 . GLN A 1 153 ? 22.177  -2.254  3.299   1.000 37.369  0 176 GLN A OE1 1 ? 
ATOM   1222 N  NE2 . GLN A 1 153 ? 22.802  -2.033  5.411   1.000 27.102  0 176 GLN A NE2 1 ? 
ATOM   1223 N  N   . ARG A 1 154 ? 19.215  0.785   7.916   1.000 24.435  0 177 ARG A N   1 ? 
ATOM   1224 C  CA  . ARG A 1 154 ? 19.575  2.035   8.561   1.000 28.698  0 177 ARG A CA  1 ? 
ATOM   1225 C  C   . ARG A 1 154 ? 21.087  2.049   8.737   1.000 30.421  0 177 ARG A C   1 ? 
ATOM   1226 O  O   . ARG A 1 154 ? 21.680  1.074   9.198   1.000 32.547  0 177 ARG A O   1 ? 
ATOM   1227 C  CB  . ARG A 1 154 ? 18.925  2.199   9.934   1.000 31.726  0 177 ARG A CB  1 ? 
ATOM   1228 C  CG  . ARG A 1 154 ? 17.488  1.740   10.043  1.000 40.477  0 177 ARG A CG  1 ? 
ATOM   1229 C  CD  . ARG A 1 154 ? 17.134  1.367   11.485  1.000 44.931  0 177 ARG A CD  1 ? 
ATOM   1230 N  NE  . ARG A 1 154 ? 15.785  0.820   11.578  1.000 39.867  0 177 ARG A NE  1 ? 
ATOM   1231 C  CZ  . ARG A 1 154 ? 14.677  1.537   11.408  1.000 37.434  0 177 ARG A CZ  1 ? 
ATOM   1232 N  NH1 . ARG A 1 154 ? 14.753  2.822   11.107  1.000 35.793  0 177 ARG A NH1 1 ? 
ATOM   1233 N  NH2 . ARG A 1 154 ? 13.494  0.953   11.501  1.000 46.950  0 177 ARG A NH2 1 ? 
ATOM   1234 N  N   . LEU A 1 155 ? 21.709  3.123   8.268   1.000 28.434  0 178 LEU A N   1 ? 
ATOM   1235 C  CA  . LEU A 1 155 ? 23.145  3.260   8.335   1.000 26.106  0 178 LEU A CA  1 ? 
ATOM   1236 C  C   . LEU A 1 155 ? 23.412  4.448   9.247   1.000 26.154  0 178 LEU A C   1 ? 
ATOM   1237 O  O   . LEU A 1 155 ? 23.085  5.570   8.889   1.000 26.848  0 178 LEU A O   1 ? 
ATOM   1238 C  CB  . LEU A 1 155 ? 23.685  3.459   6.918   1.000 28.952  0 178 LEU A CB  1 ? 
ATOM   1239 C  CG  . LEU A 1 155 ? 23.399  2.312   5.936   1.000 31.518  0 178 LEU A CG  1 ? 
ATOM   1240 C  CD1 . LEU A 1 155 ? 24.070  2.588   4.619   1.000 33.778  0 178 LEU A CD1 1 ? 
ATOM   1241 C  CD2 . LEU A 1 155 ? 23.875  0.980   6.489   1.000 34.356  0 178 LEU A CD2 1 ? 
ATOM   1242 N  N   . ASP A 1 156 ? 23.813  4.146   10.491  1.000 26.831  0 179 ASP A N   1 ? 
ATOM   1243 C  CA  . ASP A 1 156 ? 23.998  5.177   11.493  1.000 28.667  0 179 ASP A CA  1 ? 
ATOM   1244 C  C   . ASP A 1 156 ? 22.764  6.062   11.586  1.000 24.353  0 179 ASP A C   1 ? 
ATOM   1245 O  O   . ASP A 1 156 ? 22.868  7.287   11.619  1.000 26.423  0 179 ASP A O   1 ? 
ATOM   1246 C  CB  . ASP A 1 156 ? 25.243  6.015   11.192  1.000 28.408  0 179 ASP A CB  1 ? 
ATOM   1247 C  CG  . ASP A 1 156 ? 25.662  6.796   12.419  1.000 29.265  0 179 ASP A CG  1 ? 
ATOM   1248 O  OD1 . ASP A 1 156 ? 25.202  6.394   13.554  1.000 32.522  0 179 ASP A OD1 1 ? 
ATOM   1249 O  OD2 . ASP A 1 156 ? 26.276  7.866   12.245  1.000 32.635  0 179 ASP A OD2 1 ? 
ATOM   1250 N  N   . GLY A 1 157 ? 21.597  5.413   11.626  1.000 27.242  0 180 GLY A N   1 ? 
ATOM   1251 C  CA  . GLY A 1 157 ? 20.344  6.108   11.849  1.000 25.552  0 180 GLY A CA  1 ? 
ATOM   1252 C  C   . GLY A 1 157 ? 19.657  6.650   10.590  1.000 28.095  0 180 GLY A C   1 ? 
ATOM   1253 O  O   . GLY A 1 157 ? 18.583  7.218   10.709  1.000 32.750  0 180 GLY A O   1 ? 
ATOM   1254 N  N   . LYS A 1 158 ? 20.304  6.593   9.423   1.000 25.585  0 181 LYS A N   1 ? 
ATOM   1255 C  CA  . LYS A 1 158 ? 19.774  7.157   8.188   1.000 27.640  0 181 LYS A CA  1 ? 
ATOM   1256 C  C   . LYS A 1 158 ? 19.375  5.992   7.298   1.000 26.420  0 181 LYS A C   1 ? 
ATOM   1257 O  O   . LYS A 1 158 ? 20.204  5.107   7.073   1.000 25.550  0 181 LYS A O   1 ? 
ATOM   1258 C  CB  . LYS A 1 158 ? 20.834  8.049   7.530   1.000 36.231  0 181 LYS A CB  1 ? 
ATOM   1259 C  CG  . LYS A 1 158 ? 20.617  8.437   6.068   1.000 41.230  0 181 LYS A CG  1 ? 
ATOM   1260 C  CD  . LYS A 1 158 ? 21.917  8.660   5.269   1.000 49.982  0 181 LYS A CD  1 ? 
ATOM   1261 C  CE  . LYS A 1 158 ? 22.775  7.415   5.122   1.000 55.123  0 181 LYS A CE  1 ? 
ATOM   1262 N  NZ  . LYS A 1 158 ? 24.049  7.702   4.412   1.000 61.271  0 181 LYS A NZ  1 ? 
ATOM   1263 N  N   . THR A 1 159 ? 18.084  5.891   6.962   1.000 22.749  0 182 THR A N   1 ? 
ATOM   1264 C  CA  . THR A 1 159 ? 17.616  4.765   6.175   1.000 22.776  0 182 THR A CA  1 ? 
ATOM   1265 C  C   . THR A 1 159 ? 18.032  4.978   4.715   1.000 22.970  0 182 THR A C   1 ? 
ATOM   1266 O  O   . THR A 1 159 ? 17.920  6.104   4.181   1.000 21.615  0 182 THR A O   1 ? 
ATOM   1267 C  CB  . THR A 1 159 ? 16.092  4.626   6.275   1.000 27.007  0 182 THR A CB  1 ? 
ATOM   1268 O  OG1 . THR A 1 159 ? 15.796  4.361   7.642   1.000 27.309  0 182 THR A OG1 1 ? 
ATOM   1269 C  CG2 . THR A 1 159 ? 15.515  3.523   5.401   1.000 23.817  0 182 THR A CG2 1 ? 
ATOM   1270 N  N   . VAL A 1 160 ? 18.520  3.899   4.102   1.000 19.310  0 183 VAL A N   1 ? 
ATOM   1271 C  CA  . VAL A 1 160 ? 18.782  3.828   2.693   1.000 18.263  0 183 VAL A CA  1 ? 
ATOM   1272 C  C   . VAL A 1 160 ? 18.060  2.653   2.071   1.000 17.831  0 183 VAL A C   1 ? 
ATOM   1273 O  O   . VAL A 1 160 ? 17.785  1.651   2.716   1.000 19.869  0 183 VAL A O   1 ? 
ATOM   1274 C  CB  . VAL A 1 160 ? 20.292  3.721   2.339   1.000 20.973  0 183 VAL A CB  1 ? 
ATOM   1275 C  CG1 . VAL A 1 160 ? 21.069  4.924   2.835   1.000 23.824  0 183 VAL A CG1 1 ? 
ATOM   1276 C  CG2 . VAL A 1 160 ? 20.917  2.426   2.821   1.000 21.638  0 183 VAL A CG2 1 ? 
ATOM   1277 N  N   . TRP A 1 161 ? 17.908  2.746   0.747   1.000 19.032  0 184 TRP A N   1 ? 
ATOM   1278 C  CA  . TRP A 1 161 ? 17.520  1.638   -0.117  1.000 19.392  0 184 TRP A CA  1 ? 
ATOM   1279 C  C   . TRP A 1 161 ? 18.704  1.235   -0.970  1.000 20.523  0 184 TRP A C   1 ? 
ATOM   1280 O  O   . TRP A 1 161 ? 19.478  2.080   -1.435  1.000 20.123  0 184 TRP A O   1 ? 
ATOM   1281 C  CB  . TRP A 1 161 ? 16.393  2.052   -1.069  1.000 19.343  0 184 TRP A CB  1 ? 
ATOM   1282 C  CG  . TRP A 1 161 ? 15.037  2.246   -0.457  1.000 18.880  0 184 TRP A CG  1 ? 
ATOM   1283 C  CD1 . TRP A 1 161 ? 14.663  2.264   0.850   1.000 20.500  0 184 TRP A CD1 1 ? 
ATOM   1284 C  CD2 . TRP A 1 161 ? 13.841  2.430   -1.212  1.000 16.748  0 184 TRP A CD2 1 ? 
ATOM   1285 N  NE1 . TRP A 1 161 ? 13.311  2.453   0.965   1.000 20.395  0 184 TRP A NE1 1 ? 
ATOM   1286 C  CE2 . TRP A 1 161 ? 12.779  2.519   -0.304  1.000 18.937  0 184 TRP A CE2 1 ? 
ATOM   1287 C  CE3 . TRP A 1 161 ? 13.583  2.504   -2.576  1.000 17.847  0 184 TRP A CE3 1 ? 
ATOM   1288 C  CZ2 . TRP A 1 161 ? 11.472  2.721   -0.716  1.000 20.451  0 184 TRP A CZ2 1 ? 
ATOM   1289 C  CZ3 . TRP A 1 161 ? 12.288  2.651   -2.976  1.000 18.816  0 184 TRP A CZ3 1 ? 
ATOM   1290 C  CH2 . TRP A 1 161 ? 11.240  2.758   -2.064  1.000 21.160  0 184 TRP A CH2 1 ? 
ATOM   1291 N  N   . GLN A 1 162 ? 18.911  -0.070  -1.121  1.000 19.372  0 185 GLN A N   1 ? 
ATOM   1292 C  CA  . GLN A 1 162 ? 19.967  -0.493  -2.021  1.000 20.698  0 185 GLN A CA  1 ? 
ATOM   1293 C  C   . GLN A 1 162 ? 19.382  -1.440  -3.047  1.000 22.691  0 185 GLN A C   1 ? 
ATOM   1294 O  O   . GLN A 1 162 ? 18.491  -2.221  -2.685  1.000 22.907  0 185 GLN A O   1 ? 
ATOM   1295 C  CB  . GLN A 1 162 ? 21.051  -1.258  -1.288  1.000 22.787  0 185 GLN A CB  1 ? 
ATOM   1296 C  CG  . GLN A 1 162 ? 21.775  -0.434  -0.270  1.000 24.251  0 185 GLN A CG  1 ? 
ATOM   1297 C  CD  . GLN A 1 162 ? 22.639  -1.297  0.603   1.000 25.929  0 185 GLN A CD  1 ? 
ATOM   1298 O  OE1 . GLN A 1 162 ? 22.442  -2.521  0.719   1.000 26.376  0 185 GLN A OE1 1 ? 
ATOM   1299 N  NE2 . GLN A 1 162 ? 23.601  -0.636  1.234   1.000 25.015  0 185 GLN A NE2 1 ? 
ATOM   1300 N  N   . ALA A 1 163 ? 19.861  -1.361  -4.297  1.000 20.008  0 186 ALA A N   1 ? 
ATOM   1301 C  CA  . ALA A 1 163 ? 19.398  -2.285  -5.325  1.000 20.531  0 186 ALA A CA  1 ? 
ATOM   1302 C  C   . ALA A 1 163 ? 20.470  -3.323  -5.613  1.000 19.791  0 186 ALA A C   1 ? 
ATOM   1303 O  O   . ALA A 1 163 ? 21.606  -2.982  -5.893  1.000 19.569  0 186 ALA A O   1 ? 
ATOM   1304 C  CB  . ALA A 1 163 ? 19.028  -1.528  -6.564  1.000 23.460  0 186 ALA A CB  1 ? 
ATOM   1305 N  N   . TYR A 1 164 ? 20.066  -4.600  -5.572  1.000 17.850  0 187 TYR A N   1 ? 
ATOM   1306 C  CA  . TYR A 1 164 ? 20.906  -5.694  -6.025  1.000 19.908  0 187 TYR A CA  1 ? 
ATOM   1307 C  C   . TYR A 1 164 ? 20.223  -6.371  -7.189  1.000 20.964  0 187 TYR A C   1 ? 
ATOM   1308 O  O   . TYR A 1 164 ? 19.032  -6.642  -7.138  1.000 20.251  0 187 TYR A O   1 ? 
ATOM   1309 C  CB  . TYR A 1 164 ? 21.110  -6.729  -4.927  1.000 20.522  0 187 TYR A CB  1 ? 
ATOM   1310 C  CG  . TYR A 1 164 ? 21.804  -6.196  -3.687  1.000 20.750  0 187 TYR A CG  1 ? 
ATOM   1311 C  CD1 . TYR A 1 164 ? 21.116  -5.480  -2.726  1.000 20.425  0 187 TYR A CD1 1 ? 
ATOM   1312 C  CD2 . TYR A 1 164 ? 23.162  -6.349  -3.514  1.000 21.370  0 187 TYR A CD2 1 ? 
ATOM   1313 C  CE1 . TYR A 1 164 ? 21.764  -4.972  -1.610  1.000 21.128  0 187 TYR A CE1 1 ? 
ATOM   1314 C  CE2 . TYR A 1 164 ? 23.819  -5.833  -2.414  1.000 23.020  0 187 TYR A CE2 1 ? 
ATOM   1315 C  CZ  . TYR A 1 164 ? 23.109  -5.166  -1.436  1.000 22.473  0 187 TYR A CZ  1 ? 
ATOM   1316 O  OH  . TYR A 1 164 ? 23.726  -4.622  -0.340  1.000 23.818  0 187 TYR A OH  1 ? 
ATOM   1317 N  N   . LYS A 1 165 ? 20.975  -6.582  -8.248  1.000 19.288  0 188 LYS A N   1 ? 
ATOM   1318 C  CA  . LYS A 1 165 ? 20.472  -7.183  -9.461  1.000 18.623  0 188 LYS A CA  1 ? 
ATOM   1319 C  C   . LYS A 1 165 ? 21.505  -8.148  -10.013 1.000 20.173  0 188 LYS A C   1 ? 
ATOM   1320 O  O   . LYS A 1 165 ? 22.673  -7.837  -10.134 1.000 21.628  0 188 LYS A O   1 ? 
ATOM   1321 C  CB  . LYS A 1 165 ? 20.181  -6.172  -10.550 1.000 22.136  0 188 LYS A CB  1 ? 
ATOM   1322 C  CG  . LYS A 1 165 ? 18.994  -5.276  -10.237 1.000 24.406  0 188 LYS A CG  1 ? 
ATOM   1323 C  CD  . LYS A 1 165 ? 18.796  -4.177  -11.216 1.000 28.991  0 188 LYS A CD  1 ? 
ATOM   1324 C  CE  . LYS A 1 165 ? 19.615  -2.966  -10.868 1.000 30.027  0 188 LYS A CE  1 ? 
ATOM   1325 N  NZ  . LYS A 1 165 ? 19.330  -1.940  -11.899 1.000 31.170  0 188 LYS A NZ  1 ? 
ATOM   1326 N  N   . ASN A 1 166 ? 21.006  -9.308  -10.432 1.000 19.769  0 189 ASN A N   1 ? 
ATOM   1327 C  CA  . ASN A 1 166 ? 21.812  -10.228 -11.220 1.000 20.462  0 189 ASN A CA  1 ? 
ATOM   1328 C  C   . ASN A 1 166 ? 21.032  -10.697 -12.451 1.000 21.437  0 189 ASN A C   1 ? 
ATOM   1329 O  O   . ASN A 1 166 ? 19.814  -10.834 -12.412 1.000 20.079  0 189 ASN A O   1 ? 
ATOM   1330 C  CB  . ASN A 1 166 ? 22.180  -11.494 -10.461 1.000 20.851  0 189 ASN A CB  1 ? 
ATOM   1331 C  CG  . ASN A 1 166 ? 22.744  -11.314 -9.068  1.000 21.945  0 189 ASN A CG  1 ? 
ATOM   1332 O  OD1 . ASN A 1 166 ? 22.536  -12.188 -8.245  1.000 23.622  0 189 ASN A OD1 1 ? 
ATOM   1333 N  ND2 . ASN A 1 166 ? 23.513  -10.274 -8.823  1.000 23.107  0 189 ASN A ND2 1 ? 
ATOM   1334 N  N   A CYS A 1 167 ? 21.767  -10.978 -13.536 0.500 18.748  0 190 CYS A N   1 ? 
ATOM   1335 N  N   B CYS A 1 167 ? 21.792  -11.074 -13.489 0.500 21.868  0 190 CYS A N   1 ? 
ATOM   1336 C  CA  A CYS A 1 167 ? 21.241  -11.731 -14.659 0.500 19.681  0 190 CYS A CA  1 ? 
ATOM   1337 C  CA  B CYS A 1 167 ? 21.258  -11.675 -14.698 0.500 25.802  0 190 CYS A CA  1 ? 
ATOM   1338 C  C   A CYS A 1 167 ? 22.147  -12.939 -14.860 0.500 20.826  0 190 CYS A C   1 ? 
ATOM   1339 C  C   B CYS A 1 167 ? 22.130  -12.891 -15.022 0.500 24.224  0 190 CYS A C   1 ? 
ATOM   1340 O  O   A CYS A 1 167 ? 23.364  -12.841 -14.727 0.500 21.411  0 190 CYS A O   1 ? 
ATOM   1341 O  O   B CYS A 1 167 ? 23.336  -12.743 -15.161 0.500 24.179  0 190 CYS A O   1 ? 
ATOM   1342 C  CB  A CYS A 1 167 ? 21.173  -10.897 -15.923 0.500 20.227  0 190 CYS A CB  1 ? 
ATOM   1343 C  CB  B CYS A 1 167 ? 21.262  -10.643 -15.817 0.500 32.588  0 190 CYS A CB  1 ? 
ATOM   1344 S  SG  A CYS A 1 167 ? 20.181  -9.408  -15.696 0.500 19.531  0 190 CYS A SG  1 ? 
ATOM   1345 S  SG  B CYS A 1 167 ? 20.392  -11.189 -17.303 0.500 51.482  0 190 CYS A SG  1 ? 
ATOM   1346 N  N   . ILE A 1 168 ? 21.528  -14.085 -15.123 1.000 22.559  0 191 ILE A N   1 ? 
ATOM   1347 C  CA  . ILE A 1 168 ? 22.285  -15.309 -15.344 1.000 21.462  0 191 ILE A CA  1 ? 
ATOM   1348 C  C   . ILE A 1 168 ? 21.674  -16.054 -16.521 1.000 20.247  0 191 ILE A C   1 ? 
ATOM   1349 O  O   . ILE A 1 168 ? 20.526  -16.518 -16.435 1.000 21.221  0 191 ILE A O   1 ? 
ATOM   1350 C  CB  . ILE A 1 168 ? 22.309  -16.198 -14.094 1.000 24.256  0 191 ILE A CB  1 ? 
ATOM   1351 C  CG1 . ILE A 1 168 ? 22.820  -15.418 -12.882 1.000 27.508  0 191 ILE A CG1 1 ? 
ATOM   1352 C  CG2 . ILE A 1 168 ? 23.135  -17.434 -14.365 1.000 24.612  0 191 ILE A CG2 1 ? 
ATOM   1353 C  CD1 . ILE A 1 168 ? 22.703  -16.127 -11.589 1.000 26.191  0 191 ILE A CD1 1 ? 
ATOM   1354 N  N   . PRO A 1 169 ? 22.405  -16.213 -17.638 1.000 21.736  0 192 PRO A N   1 ? 
ATOM   1355 C  CA  . PRO A 1 169 ? 21.865  -16.960 -18.781 1.000 23.039  0 192 PRO A CA  1 ? 
ATOM   1356 C  C   . PRO A 1 169 ? 21.877  -18.468 -18.526 1.000 20.829  0 192 PRO A C   1 ? 
ATOM   1357 O  O   . PRO A 1 169 ? 22.885  -19.000 -18.079 1.000 22.913  0 192 PRO A O   1 ? 
ATOM   1358 C  CB  . PRO A 1 169 ? 22.823  -16.579 -19.908 1.000 23.245  0 192 PRO A CB  1 ? 
ATOM   1359 C  CG  . PRO A 1 169 ? 24.106  -16.318 -19.211 1.000 23.973  0 192 PRO A CG  1 ? 
ATOM   1360 C  CD  . PRO A 1 169 ? 23.772  -15.707 -17.860 1.000 22.696  0 192 PRO A CD  1 ? 
ATOM   1361 N  N   . LEU A 1 170 ? 20.739  -19.105 -18.734 1.000 23.561  0 193 LEU A N   1 ? 
ATOM   1362 C  CA  . LEU A 1 170 ? 20.570  -20.535 -18.518 1.000 23.877  0 193 LEU A CA  1 ? 
ATOM   1363 C  C   . LEU A 1 170 ? 20.439  -21.274 -19.836 1.000 26.487  0 193 LEU A C   1 ? 
ATOM   1364 O  O   . LEU A 1 170 ? 19.859  -20.776 -20.785 1.000 28.268  0 193 LEU A O   1 ? 
ATOM   1365 C  CB  . LEU A 1 170 ? 19.293  -20.775 -17.718 1.000 24.993  0 193 LEU A CB  1 ? 
ATOM   1366 C  CG  . LEU A 1 170 ? 19.278  -20.110 -16.335 1.000 26.744  0 193 LEU A CG  1 ? 
ATOM   1367 C  CD1 . LEU A 1 170 ? 18.034  -20.501 -15.588 1.000 28.655  0 193 LEU A CD1 1 ? 
ATOM   1368 C  CD2 . LEU A 1 170 ? 20.516  -20.416 -15.549 1.000 24.809  0 193 LEU A CD2 1 ? 
ATOM   1369 N  N   . THR A 1 171 ? 20.942  -22.503 -19.842 1.000 27.777  0 194 THR A N   1 ? 
ATOM   1370 C  CA  . THR A 1 171 ? 20.720  -23.374 -20.973 1.000 34.562  0 194 THR A CA  1 ? 
ATOM   1371 C  C   . THR A 1 171 ? 19.298  -23.932 -20.882 1.000 40.125  0 194 THR A C   1 ? 
ATOM   1372 O  O   . THR A 1 171 ? 18.730  -24.053 -19.793 1.000 46.999  0 194 THR A O   1 ? 
ATOM   1373 C  CB  . THR A 1 171 ? 21.820  -24.443 -21.024 1.000 30.606  0 194 THR A CB  1 ? 
ATOM   1374 O  OG1 . THR A 1 171 ? 21.817  -25.172 -19.797 1.000 31.701  0 194 THR A OG1 1 ? 
ATOM   1375 C  CG2 . THR A 1 171 ? 23.192  -23.827 -21.201 1.000 31.659  0 194 THR A CG2 1 ? 
ATOM   1376 N  N   . GLY A 1 172 ? 18.753  -24.292 -22.048 1.000 56.869  0 195 GLY A N   1 ? 
ATOM   1377 C  CA  . GLY A 1 172 ? 17.406  -24.822 -22.145 1.000 65.354  0 195 GLY A CA  1 ? 
ATOM   1378 C  C   . GLY A 1 172 ? 17.343  -26.282 -21.711 1.000 82.725  0 195 GLY A C   1 ? 
ATOM   1379 O  O   . GLY A 1 172 ? 18.263  -27.050 -22.004 1.000 78.328  0 195 GLY A O   1 ? 
ATOM   1380 N  N   . PRO A 1 173 ? 16.292  -26.666 -20.941 1.000 118.428 0 196 PRO A N   1 ? 
ATOM   1381 C  CA  . PRO A 1 173 ? 15.883  -28.067 -20.785 1.000 124.744 0 196 PRO A CA  1 ? 
ATOM   1382 C  C   . PRO A 1 173 ? 14.892  -28.557 -21.860 1.000 113.449 0 196 PRO A C   1 ? 
ATOM   1383 O  O   . PRO A 1 173 ? 14.695  -27.854 -22.848 1.000 96.511  0 196 PRO A O   1 ? 
ATOM   1384 C  CB  . PRO A 1 173 ? 15.226  -28.060 -19.392 1.000 123.814 0 196 PRO A CB  1 ? 
ATOM   1385 C  CG  . PRO A 1 173 ? 14.610  -26.672 -19.265 1.000 121.236 0 196 PRO A CG  1 ? 
ATOM   1386 C  CD  . PRO A 1 173 ? 15.493  -25.762 -20.096 1.000 119.101 0 196 PRO A CD  1 ? 
ATOM   1387 N  N   . HIS B 1 1   ? 4.167   26.573  -16.851 1.000 29.880  0 24  HIS B N   1 ? 
ATOM   1388 C  CA  . HIS B 1 1   ? 3.204   25.495  -17.179 1.000 27.537  0 24  HIS B CA  1 ? 
ATOM   1389 C  C   . HIS B 1 1   ? 3.465   25.005  -18.598 1.000 25.268  0 24  HIS B C   1 ? 
ATOM   1390 O  O   . HIS B 1 1   ? 4.021   25.723  -19.444 1.000 29.164  0 24  HIS B O   1 ? 
ATOM   1391 C  CB  . HIS B 1 1   ? 1.769   26.005  -17.048 1.000 28.924  0 24  HIS B CB  1 ? 
ATOM   1392 C  CG  . HIS B 1 1   ? 1.273   26.002  -15.649 1.000 26.147  0 24  HIS B CG  1 ? 
ATOM   1393 N  ND1 . HIS B 1 1   ? 1.852   26.825  -14.725 1.000 27.626  0 24  HIS B ND1 1 ? 
ATOM   1394 C  CD2 . HIS B 1 1   ? 0.320   25.312  -14.997 1.000 27.852  0 24  HIS B CD2 1 ? 
ATOM   1395 C  CE1 . HIS B 1 1   ? 1.249   26.660  -13.553 1.000 29.465  0 24  HIS B CE1 1 ? 
ATOM   1396 N  NE2 . HIS B 1 1   ? 0.312   25.729  -13.684 1.000 28.980  0 24  HIS B NE2 1 ? 
ATOM   1397 N  N   . GLY B 1 2   ? 3.039   23.781  -18.854 1.000 24.142  0 25  GLY B N   1 ? 
ATOM   1398 C  CA  . GLY B 1 2   ? 3.145   23.203  -20.183 1.000 23.815  0 25  GLY B CA  1 ? 
ATOM   1399 C  C   . GLY B 1 2   ? 3.775   21.816  -20.136 1.000 24.389  0 25  GLY B C   1 ? 
ATOM   1400 O  O   . GLY B 1 2   ? 4.354   21.411  -19.126 1.000 26.180  0 25  GLY B O   1 ? 
ATOM   1401 N  N   . TYR B 1 3   ? 3.683   21.122  -21.276 1.000 24.263  0 26  TYR B N   1 ? 
ATOM   1402 C  CA  . TYR B 1 3   ? 4.266   19.802  -21.475 1.000 21.007  0 26  TYR B CA  1 ? 
ATOM   1403 C  C   . TYR B 1 3   ? 4.725   19.651  -22.924 1.000 23.840  0 26  TYR B C   1 ? 
ATOM   1404 O  O   . TYR B 1 3   ? 4.277   20.383  -23.788 1.000 22.754  0 26  TYR B O   1 ? 
ATOM   1405 C  CB  . TYR B 1 3   ? 3.273   18.694  -21.096 1.000 23.099  0 26  TYR B CB  1 ? 
ATOM   1406 C  CG  . TYR B 1 3   ? 2.001   18.708  -21.920 1.000 24.883  0 26  TYR B CG  1 ? 
ATOM   1407 C  CD1 . TYR B 1 3   ? 0.915   19.516  -21.568 1.000 25.300  0 26  TYR B CD1 1 ? 
ATOM   1408 C  CD2 . TYR B 1 3   ? 1.923   17.995  -23.111 1.000 27.636  0 26  TYR B CD2 1 ? 
ATOM   1409 C  CE1 . TYR B 1 3   ? -0.220  19.563  -22.367 1.000 33.517  0 26  TYR B CE1 1 ? 
ATOM   1410 C  CE2 . TYR B 1 3   ? 0.792   18.025  -23.907 1.000 29.159  0 26  TYR B CE2 1 ? 
ATOM   1411 C  CZ  . TYR B 1 3   ? -0.267  18.833  -23.549 1.000 33.835  0 26  TYR B CZ  1 ? 
ATOM   1412 O  OH  . TYR B 1 3   ? -1.367  18.826  -24.354 1.000 34.950  0 26  TYR B OH  1 ? 
ATOM   1413 N  N   . ILE B 1 4   ? 5.644   18.720  -23.168 1.000 24.974  0 27  ILE B N   1 ? 
ATOM   1414 C  CA  . ILE B 1 4   ? 6.002   18.374  -24.531 1.000 24.175  0 27  ILE B CA  1 ? 
ATOM   1415 C  C   . ILE B 1 4   ? 4.815   17.678  -25.197 1.000 26.446  0 27  ILE B C   1 ? 
ATOM   1416 O  O   . ILE B 1 4   ? 4.376   16.616  -24.756 1.000 26.466  0 27  ILE B O   1 ? 
ATOM   1417 C  CB  . ILE B 1 4   ? 7.287   17.530  -24.589 1.000 27.187  0 27  ILE B CB  1 ? 
ATOM   1418 C  CG1 . ILE B 1 4   ? 8.491   18.392  -24.158 1.000 27.465  0 27  ILE B CG1 1 ? 
ATOM   1419 C  CG2 . ILE B 1 4   ? 7.475   16.945  -25.990 1.000 26.758  0 27  ILE B CG2 1 ? 
ATOM   1420 C  CD1 . ILE B 1 4   ? 9.790   17.731  -24.325 1.000 36.148  0 27  ILE B CD1 1 ? 
ATOM   1421 N  N   . ALA B 1 5   ? 4.343   18.292  -26.294 1.000 26.068  0 28  ALA B N   1 ? 
ATOM   1422 C  CA  . ALA B 1 5   ? 3.152   17.855  -27.007 1.000 27.786  0 28  ALA B CA  1 ? 
ATOM   1423 C  C   . ALA B 1 5   ? 3.507   17.020  -28.245 1.000 28.066  0 28  ALA B C   1 ? 
ATOM   1424 O  O   . ALA B 1 5   ? 2.711   16.157  -28.651 1.000 26.028  0 28  ALA B O   1 ? 
ATOM   1425 C  CB  . ALA B 1 5   ? 2.364   19.089  -27.385 1.000 30.291  0 28  ALA B CB  1 ? 
ATOM   1426 N  N   . LYS B 1 6   ? 4.670   17.301  -28.859 1.000 24.768  0 29  LYS B N   1 ? 
ATOM   1427 C  CA  . LYS B 1 6   ? 5.164   16.449  -29.937 1.000 27.901  0 29  LYS B CA  1 ? 
ATOM   1428 C  C   . LYS B 1 6   ? 6.651   16.190  -29.699 1.000 28.171  0 29  LYS B C   1 ? 
ATOM   1429 O  O   . LYS B 1 6   ? 7.426   17.121  -29.546 1.000 27.477  0 29  LYS B O   1 ? 
ATOM   1430 C  CB  . LYS B 1 6   ? 4.984   17.083  -31.321 1.000 33.708  0 29  LYS B CB  1 ? 
ATOM   1431 C  CG  . LYS B 1 6   ? 3.607   17.622  -31.656 1.000 42.368  0 29  LYS B CG  1 ? 
ATOM   1432 C  CD  . LYS B 1 6   ? 3.610   18.435  -32.949 1.000 58.535  0 29  LYS B CD  1 ? 
ATOM   1433 C  CE  . LYS B 1 6   ? 2.316   19.179  -33.228 1.000 65.326  0 29  LYS B CE  1 ? 
ATOM   1434 N  NZ  . LYS B 1 6   ? 1.220   18.232  -33.540 1.000 70.027  0 29  LYS B NZ  1 ? 
ATOM   1435 N  N   . PRO B 1 7   ? 7.092   14.932  -29.535 1.000 24.201  0 30  PRO B N   1 ? 
ATOM   1436 C  CA  . PRO B 1 7   ? 6.199   13.776  -29.579 1.000 26.189  0 30  PRO B CA  1 ? 
ATOM   1437 C  C   . PRO B 1 7   ? 5.197   13.695  -28.426 1.000 30.600  0 30  PRO B C   1 ? 
ATOM   1438 O  O   . PRO B 1 7   ? 5.380   14.354  -27.402 1.000 26.146  0 30  PRO B O   1 ? 
ATOM   1439 C  CB  . PRO B 1 7   ? 7.152   12.607  -29.447 1.000 26.468  0 30  PRO B CB  1 ? 
ATOM   1440 C  CG  . PRO B 1 7   ? 8.298   13.145  -28.615 1.000 27.439  0 30  PRO B CG  1 ? 
ATOM   1441 C  CD  . PRO B 1 7   ? 8.421   14.586  -29.048 1.000 25.924  0 30  PRO B CD  1 ? 
ATOM   1442 N  N   . GLU B 1 8   ? 4.164   12.861  -28.626 1.000 30.219  0 31  GLU B N   1 ? 
ATOM   1443 C  CA  . GLU B 1 8   ? 2.936   12.900  -27.844 1.000 34.555  0 31  GLU B CA  1 ? 
ATOM   1444 C  C   . GLU B 1 8   ? 3.005   11.980  -26.623 1.000 29.253  0 31  GLU B C   1 ? 
ATOM   1445 O  O   . GLU B 1 8   ? 3.149   10.757  -26.763 1.000 30.186  0 31  GLU B O   1 ? 
ATOM   1446 C  CB  . GLU B 1 8   ? 1.794   12.484  -28.771 1.000 42.130  0 31  GLU B CB  1 ? 
ATOM   1447 C  CG  . GLU B 1 8   ? 0.536   12.015  -28.067 1.000 59.028  0 31  GLU B CG  1 ? 
ATOM   1448 C  CD  . GLU B 1 8   ? -0.697  12.896  -28.169 1.000 71.453  0 31  GLU B CD  1 ? 
ATOM   1449 O  OE1 . GLU B 1 8   ? -1.284  12.968  -29.271 1.000 70.268  0 31  GLU B OE1 1 ? 
ATOM   1450 O  OE2 . GLU B 1 8   ? -1.087  13.474  -27.131 1.000 91.758  0 31  GLU B OE2 1 ? 
ATOM   1451 N  N   . PRO B 1 9   ? 2.897   12.511  -25.385 1.000 26.922  0 32  PRO B N   1 ? 
ATOM   1452 C  CA  . PRO B 1 9   ? 2.920   11.668  -24.194 1.000 28.170  0 32  PRO B CA  1 ? 
ATOM   1453 C  C   . PRO B 1 9   ? 1.568   10.987  -23.965 1.000 26.064  0 32  PRO B C   1 ? 
ATOM   1454 O  O   . PRO B 1 9   ? 0.571   11.445  -24.496 1.000 30.180  0 32  PRO B O   1 ? 
ATOM   1455 C  CB  . PRO B 1 9   ? 3.212   12.638  -23.038 1.000 30.489  0 32  PRO B CB  1 ? 
ATOM   1456 C  CG  . PRO B 1 9   ? 2.734   13.984  -23.533 1.000 32.520  0 32  PRO B CG  1 ? 
ATOM   1457 C  CD  . PRO B 1 9   ? 2.803   13.948  -25.048 1.000 31.824  0 32  PRO B CD  1 ? 
ATOM   1458 N  N   . SER B 1 10  ? 1.588   9.915   -23.182 1.000 28.672  0 33  SER B N   1 ? 
ATOM   1459 C  CA  . SER B 1 10  ? 0.402   9.351   -22.540 1.000 29.623  0 33  SER B CA  1 ? 
ATOM   1460 C  C   . SER B 1 10  ? 0.367   9.794   -21.088 1.000 29.596  0 33  SER B C   1 ? 
ATOM   1461 O  O   . SER B 1 10  ? 1.385   10.226  -20.543 1.000 29.466  0 33  SER B O   1 ? 
ATOM   1462 C  CB  . SER B 1 10  ? 0.407   7.838   -22.582 1.000 33.459  0 33  SER B CB  1 ? 
ATOM   1463 O  OG  . SER B 1 10  ? 0.576   7.389   -23.898 1.000 39.085  0 33  SER B OG  1 ? 
ATOM   1464 N  N   . TRP B 1 11  ? -0.803  9.647   -20.464 1.000 27.798  0 34  TRP B N   1 ? 
ATOM   1465 C  CA  . TRP B 1 11  ? -1.076  10.240  -19.166 1.000 28.348  0 34  TRP B CA  1 ? 
ATOM   1466 C  C   . TRP B 1 11  ? -1.533  9.180   -18.178 1.000 32.649  0 34  TRP B C   1 ? 
ATOM   1467 O  O   . TRP B 1 11  ? -2.228  8.239   -18.544 1.000 33.406  0 34  TRP B O   1 ? 
ATOM   1468 C  CB  . TRP B 1 11  ? -2.090  11.379  -19.311 1.000 27.469  0 34  TRP B CB  1 ? 
ATOM   1469 C  CG  . TRP B 1 11  ? -1.599  12.456  -20.221 1.000 29.428  0 34  TRP B CG  1 ? 
ATOM   1470 C  CD1 . TRP B 1 11  ? -1.826  12.605  -21.556 1.000 36.755  0 34  TRP B CD1 1 ? 
ATOM   1471 C  CD2 . TRP B 1 11  ? -0.737  13.544  -19.832 1.000 28.909  0 34  TRP B CD2 1 ? 
ATOM   1472 N  NE1 . TRP B 1 11  ? -1.165  13.706  -22.025 1.000 34.745  0 34  TRP B NE1 1 ? 
ATOM   1473 C  CE2 . TRP B 1 11  ? -0.476  14.290  -20.990 1.000 30.835  0 34  TRP B CE2 1 ? 
ATOM   1474 C  CE3 . TRP B 1 11  ? -0.169  13.952  -18.615 1.000 27.388  0 34  TRP B CE3 1 ? 
ATOM   1475 C  CZ2 . TRP B 1 11  ? 0.299   15.449  -20.965 1.000 29.574  0 34  TRP B CZ2 1 ? 
ATOM   1476 C  CZ3 . TRP B 1 11  ? 0.623   15.078  -18.596 1.000 28.842  0 34  TRP B CZ3 1 ? 
ATOM   1477 C  CH2 . TRP B 1 11  ? 0.856   15.810  -19.768 1.000 27.074  0 34  TRP B CH2 1 ? 
ATOM   1478 N  N   . LYS B 1 12  ? -1.012  9.245   -16.959 1.000 30.061  0 35  LYS B N   1 ? 
ATOM   1479 C  CA  . LYS B 1 12  ? -1.461  8.312   -15.934 1.000 38.439  0 35  LYS B CA  1 ? 
ATOM   1480 C  C   . LYS B 1 12  ? -2.980  8.430   -15.732 1.000 39.916  0 35  LYS B C   1 ? 
ATOM   1481 O  O   . LYS B 1 12  ? -3.649  7.411   -15.543 1.000 38.996  0 35  LYS B O   1 ? 
ATOM   1482 C  CB  . LYS B 1 12  ? -0.671  8.541   -14.639 1.000 36.050  0 35  LYS B CB  1 ? 
ATOM   1483 C  CG  . LYS B 1 12  ? 0.764   8.046   -14.677 1.000 38.471  0 35  LYS B CG  1 ? 
ATOM   1484 C  CD  . LYS B 1 12  ? 1.625   8.596   -13.566 1.000 46.178  0 35  LYS B CD  1 ? 
ATOM   1485 C  CE  . LYS B 1 12  ? 2.992   7.947   -13.536 1.000 48.215  0 35  LYS B CE  1 ? 
ATOM   1486 N  NZ  . LYS B 1 12  ? 4.051   8.963   -13.357 1.000 43.032  0 35  LYS B NZ  1 ? 
ATOM   1487 N  N   . ASP B 1 13  ? -3.503  9.661   -15.738 1.000 41.582  0 36  ASP B N   1 ? 
ATOM   1488 C  CA  . ASP B 1 13  ? -4.929  9.935   -15.610 1.000 44.768  0 36  ASP B CA  1 ? 
ATOM   1489 C  C   . ASP B 1 13  ? -5.358  10.709  -16.839 1.000 38.335  0 36  ASP B C   1 ? 
ATOM   1490 O  O   . ASP B 1 13  ? -5.551  10.119  -17.886 1.000 43.643  0 36  ASP B O   1 ? 
ATOM   1491 C  CB  . ASP B 1 13  ? -5.277  10.795  -14.394 1.000 58.355  0 36  ASP B CB  1 ? 
ATOM   1492 C  CG  . ASP B 1 13  ? -5.657  10.048  -13.134 1.000 75.721  0 36  ASP B CG  1 ? 
ATOM   1493 O  OD1 . ASP B 1 13  ? -5.342  8.839   -13.038 1.000 90.865  0 36  ASP B OD1 1 ? 
ATOM   1494 O  OD2 . ASP B 1 13  ? -6.298  10.689  -12.268 1.000 91.941  0 36  ASP B OD2 1 ? 
ATOM   1495 N  N   . LYS B 1 14  ? -5.363  12.046  -16.740 1.000 45.154  0 37  LYS B N   1 ? 
ATOM   1496 C  CA  . LYS B 1 14  ? -5.674  12.893  -17.879 1.000 45.605  0 37  LYS B CA  1 ? 
ATOM   1497 C  C   . LYS B 1 14  ? -4.553  13.905  -18.115 1.000 39.771  0 37  LYS B C   1 ? 
ATOM   1498 O  O   . LYS B 1 14  ? -3.725  14.159  -17.251 1.000 38.734  0 37  LYS B O   1 ? 
ATOM   1499 C  CB  . LYS B 1 14  ? -6.991  13.634  -17.636 1.000 60.208  0 37  LYS B CB  1 ? 
ATOM   1500 C  CG  . LYS B 1 14  ? -8.188  12.728  -17.365 1.000 76.734  0 37  LYS B CG  1 ? 
ATOM   1501 C  CD  . LYS B 1 14  ? -9.438  13.478  -16.938 1.000 89.401  0 37  LYS B CD  1 ? 
ATOM   1502 C  CE  . LYS B 1 14  ? -10.449 12.593  -16.238 1.000 97.464  0 37  LYS B CE  1 ? 
ATOM   1503 N  NZ  . LYS B 1 14  ? -11.583 13.384  -15.704 1.000 103.397 0 37  LYS B NZ  1 ? 
ATOM   1504 N  N   . LYS B 1 15  ? -4.582  14.494  -19.299 1.000 39.322  0 38  LYS B N   1 ? 
ATOM   1505 C  CA  . LYS B 1 15  ? -3.613  15.485  -19.715 1.000 41.731  0 38  LYS B CA  1 ? 
ATOM   1506 C  C   . LYS B 1 15  ? -3.654  16.662  -18.726 1.000 40.798  0 38  LYS B C   1 ? 
ATOM   1507 O  O   . LYS B 1 15  ? -4.723  17.102  -18.340 1.000 35.844  0 38  LYS B O   1 ? 
ATOM   1508 C  CB  . LYS B 1 15  ? -3.942  15.835  -21.167 1.000 49.287  0 38  LYS B CB  1 ? 
ATOM   1509 C  CG  . LYS B 1 15  ? -3.326  17.117  -21.691 1.000 58.389  0 38  LYS B CG  1 ? 
ATOM   1510 C  CD  . LYS B 1 15  ? -4.348  18.003  -22.376 1.000 69.143  0 38  LYS B CD  1 ? 
ATOM   1511 C  CE  . LYS B 1 15  ? -4.400  19.369  -21.722 1.000 78.772  0 38  LYS B CE  1 ? 
ATOM   1512 N  NZ  . LYS B 1 15  ? -5.328  20.293  -22.412 1.000 86.033  0 38  LYS B NZ  1 ? 
ATOM   1513 N  N   . THR B 1 16  ? -2.487  17.164  -18.294 1.000 35.061  0 39  THR B N   1 ? 
ATOM   1514 C  CA  . THR B 1 16  ? -2.418  18.369  -17.474 1.000 30.874  0 39  THR B CA  1 ? 
ATOM   1515 C  C   . THR B 1 16  ? -1.112  19.093  -17.798 1.000 28.943  0 39  THR B C   1 ? 
ATOM   1516 O  O   . THR B 1 16  ? -0.116  18.453  -18.113 1.000 26.849  0 39  THR B O   1 ? 
ATOM   1517 C  CB  . THR B 1 16  ? -2.526  18.050  -15.976 1.000 35.219  0 39  THR B CB  1 ? 
ATOM   1518 O  OG1 . THR B 1 16  ? -2.271  19.235  -15.235 1.000 33.540  0 39  THR B OG1 1 ? 
ATOM   1519 C  CG2 . THR B 1 16  ? -1.535  17.006  -15.521 1.000 38.646  0 39  THR B CG2 1 ? 
ATOM   1520 N  N   . ASN B 1 17  ? -1.132  20.424  -17.731 1.000 25.550  0 40  ASN B N   1 ? 
ATOM   1521 C  CA  . ASN B 1 17  ? 0.075   21.198  -17.936 1.000 26.439  0 40  ASN B CA  1 ? 
ATOM   1522 C  C   . ASN B 1 17  ? 0.730   21.570  -16.610 1.000 24.582  0 40  ASN B C   1 ? 
ATOM   1523 O  O   . ASN B 1 17  ? 1.640   22.381  -16.578 1.000 23.618  0 40  ASN B O   1 ? 
ATOM   1524 C  CB  . ASN B 1 17  ? -0.224  22.410  -18.799 1.000 33.415  0 40  ASN B CB  1 ? 
ATOM   1525 C  CG  . ASN B 1 17  ? -1.242  23.309  -18.161 1.000 43.250  0 40  ASN B CG  1 ? 
ATOM   1526 O  OD1 . ASN B 1 17  ? -1.586  23.126  -16.993 1.000 45.965  0 40  ASN B OD1 1 ? 
ATOM   1527 N  ND2 . ASN B 1 17  ? -1.669  24.303  -18.920 1.000 49.224  0 40  ASN B ND2 1 ? 
ATOM   1528 N  N   . ASP B 1 18  ? 0.268   20.978  -15.513 1.000 24.713  0 41  ASP B N   1 ? 
ATOM   1529 C  CA  . ASP B 1 18  ? 0.730   21.361  -14.188 1.000 25.180  0 41  ASP B CA  1 ? 
ATOM   1530 C  C   . ASP B 1 18  ? 2.133   20.820  -13.903 1.000 22.608  0 41  ASP B C   1 ? 
ATOM   1531 O  O   . ASP B 1 18  ? 2.590   19.815  -14.457 1.000 23.258  0 41  ASP B O   1 ? 
ATOM   1532 C  CB  . ASP B 1 18  ? -0.222  20.845  -13.093 1.000 30.785  0 41  ASP B CB  1 ? 
ATOM   1533 C  CG  . ASP B 1 18  ? -1.548  21.598  -12.978 1.000 41.155  0 41  ASP B CG  1 ? 
ATOM   1534 O  OD1 . ASP B 1 18  ? -1.660  22.716  -13.530 1.000 43.670  0 41  ASP B OD1 1 ? 
ATOM   1535 O  OD2 . ASP B 1 18  ? -2.461  21.060  -12.321 1.000 44.355  0 41  ASP B OD2 1 ? 
ATOM   1536 N  N   . TRP B 1 19  ? 2.763   21.541  -12.971 1.000 23.802  0 42  TRP B N   1 ? 
ATOM   1537 C  CA  . TRP B 1 19  ? 3.995   21.148  -12.338 1.000 23.511  0 42  TRP B CA  1 ? 
ATOM   1538 C  C   . TRP B 1 19  ? 3.770   19.936  -11.448 1.000 24.201  0 42  TRP B C   1 ? 
ATOM   1539 O  O   . TRP B 1 19  ? 2.656   19.668  -10.986 1.000 22.901  0 42  TRP B O   1 ? 
ATOM   1540 C  CB  . TRP B 1 19  ? 4.585   22.322  -11.547 1.000 23.395  0 42  TRP B CB  1 ? 
ATOM   1541 C  CG  . TRP B 1 19  ? 3.604   23.172  -10.808 1.000 21.829  0 42  TRP B CG  1 ? 
ATOM   1542 C  CD1 . TRP B 1 19  ? 3.245   24.441  -11.152 1.000 23.742  0 42  TRP B CD1 1 ? 
ATOM   1543 C  CD2 . TRP B 1 19  ? 3.021   22.929  -9.499  1.000 22.659  0 42  TRP B CD2 1 ? 
ATOM   1544 N  NE1 . TRP B 1 19  ? 2.404   24.960  -10.197 1.000 23.647  0 42  TRP B NE1 1 ? 
ATOM   1545 C  CE2 . TRP B 1 19  ? 2.246   24.070  -9.181  1.000 23.528  0 42  TRP B CE2 1 ? 
ATOM   1546 C  CE3 . TRP B 1 19  ? 3.049   21.871  -8.595  1.000 25.113  0 42  TRP B CE3 1 ? 
ATOM   1547 C  CZ2 . TRP B 1 19  ? 1.546   24.193  -7.972  1.000 23.895  0 42  TRP B CZ2 1 ? 
ATOM   1548 C  CZ3 . TRP B 1 19  ? 2.298   21.948  -7.437  1.000 24.708  0 42  TRP B CZ3 1 ? 
ATOM   1549 C  CH2 . TRP B 1 19  ? 1.564   23.108  -7.136  1.000 25.557  0 42  TRP B CH2 1 ? 
ATOM   1550 N  N   . VAL B 1 20  ? 4.842   19.164  -11.264 1.000 21.095  0 43  VAL B N   1 ? 
ATOM   1551 C  CA  . VAL B 1 20  ? 4.822   18.004  -10.407 1.000 21.736  0 43  VAL B CA  1 ? 
ATOM   1552 C  C   . VAL B 1 20  ? 4.822   18.447  -8.952  1.000 23.151  0 43  VAL B C   1 ? 
ATOM   1553 O  O   . VAL B 1 20  ? 4.066   17.912  -8.148  1.000 21.607  0 43  VAL B O   1 ? 
ATOM   1554 C  CB  . VAL B 1 20  ? 5.976   17.051  -10.744 1.000 21.978  0 43  VAL B CB  1 ? 
ATOM   1555 C  CG1 . VAL B 1 20  ? 5.888   15.786  -9.934  1.000 21.891  0 43  VAL B CG1 1 ? 
ATOM   1556 C  CG2 . VAL B 1 20  ? 5.977   16.753  -12.258 1.000 23.778  0 43  VAL B CG2 1 ? 
ATOM   1557 N  N   . VAL B 1 21  ? 5.678   19.419  -8.622  1.000 22.816  0 44  VAL B N   1 ? 
ATOM   1558 C  CA  . VAL B 1 21  ? 5.773   19.950  -7.263  1.000 21.610  0 44  VAL B CA  1 ? 
ATOM   1559 C  C   . VAL B 1 21  ? 6.101   21.415  -7.416  1.000 22.575  0 44  VAL B C   1 ? 
ATOM   1560 O  O   . VAL B 1 21  ? 6.640   21.816  -8.453  1.000 20.497  0 44  VAL B O   1 ? 
ATOM   1561 C  CB  . VAL B 1 21  ? 6.845   19.275  -6.380  1.000 22.850  0 44  VAL B CB  1 ? 
ATOM   1562 C  CG1 . VAL B 1 21  ? 6.554   17.797  -6.176  1.000 23.068  0 44  VAL B CG1 1 ? 
ATOM   1563 C  CG2 . VAL B 1 21  ? 8.274   19.507  -6.896  1.000 21.395  0 44  VAL B CG2 1 ? 
ATOM   1564 N  N   . GLU B 1 22  ? 5.810   22.144  -6.354  1.000 19.870  0 45  GLU B N   1 ? 
ATOM   1565 C  CA  . GLU B 1 22  ? 6.181   23.542  -6.208  1.000 20.962  0 45  GLU B CA  1 ? 
ATOM   1566 C  C   . GLU B 1 22  ? 6.713   23.671  -4.795  1.000 26.066  0 45  GLU B C   1 ? 
ATOM   1567 O  O   . GLU B 1 22  ? 5.985   23.348  -3.858  1.000 24.162  0 45  GLU B O   1 ? 
ATOM   1568 C  CB  . GLU B 1 22  ? 4.970   24.466  -6.369  1.000 22.950  0 45  GLU B CB  1 ? 
ATOM   1569 C  CG  . GLU B 1 22  ? 5.341   25.932  -6.216  1.000 23.676  0 45  GLU B CG  1 ? 
ATOM   1570 C  CD  . GLU B 1 22  ? 4.149   26.878  -6.308  1.000 29.105  0 45  GLU B CD  1 ? 
ATOM   1571 O  OE1 . GLU B 1 22  ? 3.862   27.378  -7.420  1.000 29.098  0 45  GLU B OE1 1 ? 
ATOM   1572 O  OE2 . GLU B 1 22  ? 3.489   27.100  -5.244  1.000 29.801  0 45  GLU B OE2 1 ? 
ATOM   1573 N  N   . ILE B 1 23  ? 7.997   24.018  -4.668  1.000 22.375  0 46  ILE B N   1 ? 
ATOM   1574 C  CA  . ILE B 1 23  ? 8.738   23.872  -3.421  1.000 22.578  0 46  ILE B CA  1 ? 
ATOM   1575 C  C   . ILE B 1 23  ? 9.562   25.125  -3.183  1.000 20.970  0 46  ILE B C   1 ? 
ATOM   1576 O  O   . ILE B 1 23  ? 9.816   25.911  -4.091  1.000 22.054  0 46  ILE B O   1 ? 
ATOM   1577 C  CB  . ILE B 1 23  ? 9.645   22.624  -3.457  1.000 24.914  0 46  ILE B CB  1 ? 
ATOM   1578 C  CG1 . ILE B 1 23  ? 10.694  22.732  -4.568  1.000 23.997  0 46  ILE B CG1 1 ? 
ATOM   1579 C  CG2 . ILE B 1 23  ? 8.793   21.370  -3.567  1.000 22.352  0 46  ILE B CG2 1 ? 
ATOM   1580 C  CD1 . ILE B 1 23  ? 11.581  21.493  -4.760  1.000 27.199  0 46  ILE B CD1 1 ? 
ATOM   1581 N  N   . GLU B 1 24  ? 9.966   25.304  -1.941  1.000 22.750  0 47  GLU B N   1 ? 
ATOM   1582 C  CA  . GLU B 1 24  ? 10.962  26.299  -1.578  1.000 24.438  0 47  GLU B CA  1 ? 
ATOM   1583 C  C   . GLU B 1 24  ? 12.239  25.980  -2.321  1.000 21.127  0 47  GLU B C   1 ? 
ATOM   1584 O  O   . GLU B 1 24  ? 12.536  24.814  -2.557  1.000 22.991  0 47  GLU B O   1 ? 
ATOM   1585 C  CB  . GLU B 1 24  ? 11.304  26.217  -0.087  1.000 33.342  0 47  GLU B CB  1 ? 
ATOM   1586 C  CG  . GLU B 1 24  ? 10.130  26.560  0.802   1.000 45.338  0 47  GLU B CG  1 ? 
ATOM   1587 C  CD  . GLU B 1 24  ? 10.314  26.059  2.227   1.000 66.184  0 47  GLU B CD  1 ? 
ATOM   1588 O  OE1 . GLU B 1 24  ? 9.563   25.122  2.625   1.000 74.371  0 47  GLU B OE1 1 ? 
ATOM   1589 O  OE2 . GLU B 1 24  ? 11.234  26.581  2.922   1.000 71.332  0 47  GLU B OE2 1 ? 
ATOM   1590 N  N   . PRO B 1 25  ? 13.023  26.989  -2.698  1.000 21.587  0 48  PRO B N   1 ? 
ATOM   1591 C  CA  . PRO B 1 25  ? 14.359  26.747  -3.236  1.000 21.497  0 48  PRO B CA  1 ? 
ATOM   1592 C  C   . PRO B 1 25  ? 15.167  25.847  -2.302  1.000 21.922  0 48  PRO B C   1 ? 
ATOM   1593 O  O   . PRO B 1 25  ? 15.196  26.018  -1.074  1.000 21.803  0 48  PRO B O   1 ? 
ATOM   1594 C  CB  . PRO B 1 25  ? 14.949  28.143  -3.349  1.000 23.705  0 48  PRO B CB  1 ? 
ATOM   1595 C  CG  . PRO B 1 25  ? 13.698  29.018  -3.498  1.000 24.380  0 48  PRO B CG  1 ? 
ATOM   1596 C  CD  . PRO B 1 25  ? 12.691  28.428  -2.549  1.000 24.530  0 48  PRO B CD  1 ? 
ATOM   1597 N  N   . GLN B 1 26  ? 15.755  24.816  -2.907  1.000 21.504  0 49  GLN B N   1 ? 
ATOM   1598 C  CA  . GLN B 1 26  ? 16.418  23.762  -2.149  1.000 22.671  0 49  GLN B CA  1 ? 
ATOM   1599 C  C   . GLN B 1 26  ? 17.824  24.181  -1.705  1.000 26.285  0 49  GLN B C   1 ? 
ATOM   1600 O  O   . GLN B 1 26  ? 18.434  23.487  -0.904  1.000 24.684  0 49  GLN B O   1 ? 
ATOM   1601 C  CB  . GLN B 1 26  ? 16.407  22.478  -2.963  1.000 22.090  0 49  GLN B CB  1 ? 
ATOM   1602 C  CG  . GLN B 1 26  ? 14.995  21.947  -3.152  1.000 22.472  0 49  GLN B CG  1 ? 
ATOM   1603 C  CD  . GLN B 1 26  ? 14.392  21.565  -1.822  1.000 23.308  0 49  GLN B CD  1 ? 
ATOM   1604 O  OE1 . GLN B 1 26  ? 14.838  20.611  -1.182  1.000 24.994  0 49  GLN B OE1 1 ? 
ATOM   1605 N  NE2 . GLN B 1 26  ? 13.389  22.317  -1.411  1.000 22.947  0 49  GLN B NE2 1 ? 
ATOM   1606 N  N   . TRP B 1 27  ? 18.309  25.331  -2.191  1.000 24.014  0 50  TRP B N   1 ? 
ATOM   1607 C  CA  . TRP B 1 27  ? 19.580  25.906  -1.774  1.000 25.673  0 50  TRP B CA  1 ? 
ATOM   1608 C  C   . TRP B 1 27  ? 19.326  27.263  -1.127  1.000 26.379  0 50  TRP B C   1 ? 
ATOM   1609 O  O   . TRP B 1 27  ? 18.685  28.120  -1.709  1.000 25.894  0 50  TRP B O   1 ? 
ATOM   1610 C  CB  . TRP B 1 27  ? 20.502  26.080  -2.978  1.000 28.107  0 50  TRP B CB  1 ? 
ATOM   1611 C  CG  . TRP B 1 27  ? 20.669  24.864  -3.850  1.000 24.501  0 50  TRP B CG  1 ? 
ATOM   1612 C  CD1 . TRP B 1 27  ? 20.750  23.552  -3.503  1.000 25.137  0 50  TRP B CD1 1 ? 
ATOM   1613 C  CD2 . TRP B 1 27  ? 20.753  24.898  -5.287  1.000 22.352  0 50  TRP B CD2 1 ? 
ATOM   1614 N  NE1 . TRP B 1 27  ? 20.934  22.774  -4.621  1.000 25.981  0 50  TRP B NE1 1 ? 
ATOM   1615 C  CE2 . TRP B 1 27  ? 20.913  23.566  -5.727  1.000 22.396  0 50  TRP B CE2 1 ? 
ATOM   1616 C  CE3 . TRP B 1 27  ? 20.702  25.911  -6.232  1.000 21.260  0 50  TRP B CE3 1 ? 
ATOM   1617 C  CZ2 . TRP B 1 27  ? 21.025  23.247  -7.063  1.000 23.125  0 50  TRP B CZ2 1 ? 
ATOM   1618 C  CZ3 . TRP B 1 27  ? 20.853  25.596  -7.558  1.000 22.642  0 50  TRP B CZ3 1 ? 
ATOM   1619 C  CH2 . TRP B 1 27  ? 20.987  24.267  -7.964  1.000 23.766  0 50  TRP B CH2 1 ? 
ATOM   1620 N  N   . LYS B 1 28  ? 19.854  27.441  0.069   1.000 25.800  0 51  LYS B N   1 ? 
ATOM   1621 C  CA  . LYS B 1 28  ? 19.693  28.682  0.803   1.000 33.343  0 51  LYS B CA  1 ? 
ATOM   1622 C  C   . LYS B 1 28  ? 20.389  29.822  0.048   1.000 29.756  0 51  LYS B C   1 ? 
ATOM   1623 O  O   . LYS B 1 28  ? 21.489  29.645  -0.489  1.000 27.370  0 51  LYS B O   1 ? 
ATOM   1624 C  CB  . LYS B 1 28  ? 20.296  28.449  2.192   1.000 39.251  0 51  LYS B CB  1 ? 
ATOM   1625 C  CG  . LYS B 1 28  ? 20.289  29.653  3.118   1.000 48.301  0 51  LYS B CG  1 ? 
ATOM   1626 C  CD  . LYS B 1 28  ? 21.136  29.452  4.375   1.000 55.604  0 51  LYS B CD  1 ? 
ATOM   1627 C  CE  . LYS B 1 28  ? 21.265  30.722  5.194   1.000 61.325  0 51  LYS B CE  1 ? 
ATOM   1628 N  NZ  . LYS B 1 28  ? 19.930  31.261  5.552   1.000 62.781  0 51  LYS B NZ  1 ? 
ATOM   1629 N  N   . GLY B 1 29  ? 19.701  30.966  -0.083  1.000 28.288  0 52  GLY B N   1 ? 
ATOM   1630 C  CA  . GLY B 1 29  ? 20.276  32.133  -0.718  1.000 26.964  0 52  GLY B CA  1 ? 
ATOM   1631 C  C   . GLY B 1 29  ? 19.322  33.335  -0.752  1.000 27.257  0 52  GLY B C   1 ? 
ATOM   1632 O  O   . GLY B 1 29  ? 18.231  33.298  -0.185  1.000 25.759  0 52  GLY B O   1 ? 
ATOM   1633 N  N   . GLY B 1 30  ? 19.692  34.322  -1.570  1.000 26.033  0 53  GLY B N   1 ? 
ATOM   1634 C  CA  . GLY B 1 30  ? 19.010  35.602  -1.692  1.000 25.509  0 53  GLY B CA  1 ? 
ATOM   1635 C  C   . GLY B 1 30  ? 18.001  35.589  -2.838  1.000 24.276  0 53  GLY B C   1 ? 
ATOM   1636 O  O   . GLY B 1 30  ? 17.917  36.519  -3.616  1.000 29.451  0 53  GLY B O   1 ? 
ATOM   1637 N  N   . TRP B 1 31  ? 17.202  34.513  -2.906  1.000 25.059  0 54  TRP B N   1 ? 
ATOM   1638 C  CA  . TRP B 1 31  ? 16.230  34.344  -3.964  1.000 24.476  0 54  TRP B CA  1 ? 
ATOM   1639 C  C   . TRP B 1 31  ? 15.211  35.499  -3.991  1.000 26.426  0 54  TRP B C   1 ? 
ATOM   1640 O  O   . TRP B 1 31  ? 14.901  36.042  -5.061  1.000 30.139  0 54  TRP B O   1 ? 
ATOM   1641 C  CB  . TRP B 1 31  ? 15.526  33.009  -3.714  1.000 25.780  0 54  TRP B CB  1 ? 
ATOM   1642 C  CG  . TRP B 1 31  ? 16.451  31.824  -3.840  1.000 22.021  0 54  TRP B CG  1 ? 
ATOM   1643 C  CD1 . TRP B 1 31  ? 16.975  31.086  -2.833  1.000 24.360  0 54  TRP B CD1 1 ? 
ATOM   1644 C  CD2 . TRP B 1 31  ? 16.891  31.204  -5.071  1.000 20.298  0 54  TRP B CD2 1 ? 
ATOM   1645 N  NE1 . TRP B 1 31  ? 17.722  30.063  -3.345  1.000 23.474  0 54  TRP B NE1 1 ? 
ATOM   1646 C  CE2 . TRP B 1 31  ? 17.705  30.111  -4.703  1.000 22.773  0 54  TRP B CE2 1 ? 
ATOM   1647 C  CE3 . TRP B 1 31  ? 16.697  31.462  -6.423  1.000 19.319  0 54  TRP B CE3 1 ? 
ATOM   1648 C  CZ2 . TRP B 1 31  ? 18.298  29.261  -5.646  1.000 22.182  0 54  TRP B CZ2 1 ? 
ATOM   1649 C  CZ3 . TRP B 1 31  ? 17.281  30.633  -7.365  1.000 23.696  0 54  TRP B CZ3 1 ? 
ATOM   1650 C  CH2 . TRP B 1 31  ? 18.060  29.537  -6.972  1.000 21.868  0 54  TRP B CH2 1 ? 
ATOM   1651 N  N   . ASP B 1 32  ? 14.746  35.915  -2.811  1.000 23.087  0 55  ASP B N   1 ? 
ATOM   1652 C  CA  . ASP B 1 32  ? 13.579  36.795  -2.763  1.000 25.876  0 55  ASP B CA  1 ? 
ATOM   1653 C  C   . ASP B 1 32  ? 13.943  38.230  -3.137  1.000 30.370  0 55  ASP B C   1 ? 
ATOM   1654 O  O   . ASP B 1 32  ? 13.047  39.035  -3.368  1.000 29.192  0 55  ASP B O   1 ? 
ATOM   1655 C  CB  . ASP B 1 32  ? 12.875  36.745  -1.401  1.000 25.584  0 55  ASP B CB  1 ? 
ATOM   1656 C  CG  . ASP B 1 32  ? 12.134  35.447  -1.093  1.000 31.877  0 55  ASP B CG  1 ? 
ATOM   1657 O  OD1 . ASP B 1 32  ? 12.025  34.574  -1.983  1.000 27.983  0 55  ASP B OD1 1 ? 
ATOM   1658 O  OD2 . ASP B 1 32  ? 11.701  35.320  0.052   1.000 33.558  0 55  ASP B OD2 1 ? 
ATOM   1659 N  N   . GLU B 1 33  ? 15.241  38.542  -3.198  1.000 28.943  0 56  GLU B N   1 ? 
ATOM   1660 C  CA  . GLU B 1 33  ? 15.729  39.880  -3.520  1.000 34.947  0 56  GLU B CA  1 ? 
ATOM   1661 C  C   . GLU B 1 33  ? 15.433  40.248  -4.970  1.000 34.428  0 56  GLU B C   1 ? 
ATOM   1662 O  O   . GLU B 1 33  ? 15.242  41.425  -5.285  1.000 34.033  0 56  GLU B O   1 ? 
ATOM   1663 C  CB  . GLU B 1 33  ? 17.232  39.977  -3.248  1.000 38.536  0 56  GLU B CB  1 ? 
ATOM   1664 C  CG  . GLU B 1 33  ? 17.578  40.162  -1.769  1.000 53.277  0 56  GLU B CG  1 ? 
ATOM   1665 C  CD  . GLU B 1 33  ? 16.873  39.273  -0.748  1.000 74.302  0 56  GLU B CD  1 ? 
ATOM   1666 O  OE1 . GLU B 1 33  ? 16.051  39.817  0.043   1.000 81.078  0 56  GLU B OE1 1 ? 
ATOM   1667 O  OE2 . GLU B 1 33  ? 17.147  38.039  -0.711  1.000 78.501  0 56  GLU B OE2 1 ? 
ATOM   1668 N  N   . SER B 1 34  ? 15.347  39.249  -5.852  1.000 31.370  0 57  SER B N   1 ? 
ATOM   1669 C  CA  . SER B 1 34  ? 15.245  39.510  -7.270  1.000 31.225  0 57  SER B CA  1 ? 
ATOM   1670 C  C   . SER B 1 34  ? 13.848  39.917  -7.688  1.000 38.557  0 57  SER B C   1 ? 
ATOM   1671 O  O   . SER B 1 34  ? 12.883  39.194  -7.460  1.000 39.164  0 57  SER B O   1 ? 
ATOM   1672 C  CB  . SER B 1 34  ? 15.690  38.306  -8.064  1.000 33.884  0 57  SER B CB  1 ? 
ATOM   1673 O  OG  . SER B 1 34  ? 17.073  38.150  -7.911  1.000 28.959  0 57  SER B OG  1 ? 
ATOM   1674 N  N   . LYS B 1 35  ? 13.788  41.008  -8.448  1.000 33.989  0 58  LYS B N   1 ? 
ATOM   1675 C  CA  . LYS B 1 35  ? 12.521  41.583  -8.881  1.000 41.525  0 58  LYS B CA  1 ? 
ATOM   1676 C  C   . LYS B 1 35  ? 12.042  40.909  -10.180 1.000 46.685  0 58  LYS B C   1 ? 
ATOM   1677 O  O   . LYS B 1 35  ? 10.848  40.946  -10.502 1.000 50.320  0 58  LYS B O   1 ? 
ATOM   1678 C  CB  . LYS B 1 35  ? 12.734  43.109  -8.941  1.000 46.046  0 58  LYS B CB  1 ? 
ATOM   1679 C  CG  . LYS B 1 35  ? 11.634  43.950  -9.587  1.000 60.064  0 58  LYS B CG  1 ? 
ATOM   1680 C  CD  . LYS B 1 35  ? 10.390  44.135  -8.732  1.000 71.893  0 58  LYS B CD  1 ? 
ATOM   1681 C  CE  . LYS B 1 35  ? 9.130   44.370  -9.543  1.000 76.042  0 58  LYS B CE  1 ? 
ATOM   1682 N  NZ  . LYS B 1 35  ? 7.977   44.676  -8.666  1.000 81.251  0 58  LYS B NZ  1 ? 
ATOM   1683 N  N   . GLY B 1 36  ? 12.962  40.242  -10.900 1.000 39.682  0 59  GLY B N   1 ? 
ATOM   1684 C  CA  . GLY B 1 36  ? 12.728  39.729  -12.238 1.000 32.728  0 59  GLY B CA  1 ? 
ATOM   1685 C  C   . GLY B 1 36  ? 13.519  38.443  -12.515 1.000 37.131  0 59  GLY B C   1 ? 
ATOM   1686 O  O   . GLY B 1 36  ? 14.243  37.945  -11.662 1.000 32.498  0 59  GLY B O   1 ? 
ATOM   1687 N  N   . ASP B 1 37  ? 13.382  37.918  -13.732 1.000 32.761  0 60  ASP B N   1 ? 
ATOM   1688 C  CA  . ASP B 1 37  ? 14.012  36.664  -14.118 1.000 31.370  0 60  ASP B CA  1 ? 
ATOM   1689 C  C   . ASP B 1 37  ? 15.549  36.742  -14.146 1.000 33.415  0 60  ASP B C   1 ? 
ATOM   1690 O  O   . ASP B 1 37  ? 16.201  35.743  -13.839 1.000 29.447  0 60  ASP B O   1 ? 
ATOM   1691 C  CB  . ASP B 1 37  ? 13.437  36.211  -15.454 1.000 32.475  0 60  ASP B CB  1 ? 
ATOM   1692 C  CG  . ASP B 1 37  ? 11.968  35.800  -15.353 1.000 34.654  0 60  ASP B CG  1 ? 
ATOM   1693 O  OD1 . ASP B 1 37  ? 11.484  35.548  -14.205 1.000 33.804  0 60  ASP B OD1 1 ? 
ATOM   1694 O  OD2 . ASP B 1 37  ? 11.326  35.687  -16.420 1.000 35.306  0 60  ASP B OD2 1 ? 
ATOM   1695 N  N   . GLU B 1 38  ? 16.151  37.875  -14.563 1.000 31.342  0 61  GLU B N   1 ? 
ATOM   1696 C  CA  . GLU B 1 38  ? 17.604  37.960  -14.655 1.000 30.463  0 61  GLU B CA  1 ? 
ATOM   1697 C  C   . GLU B 1 38  ? 18.266  37.668  -13.293 1.000 29.578  0 61  GLU B C   1 ? 
ATOM   1698 O  O   . GLU B 1 38  ? 19.233  36.894  -13.213 1.000 27.327  0 61  GLU B O   1 ? 
ATOM   1699 C  CB  . GLU B 1 38  ? 18.062  39.329  -15.168 1.000 37.734  0 61  GLU B CB  1 ? 
ATOM   1700 C  CG  . GLU B 1 38  ? 19.562  39.425  -15.352 1.000 47.226  0 61  GLU B CG  1 ? 
ATOM   1701 C  CD  . GLU B 1 38  ? 20.075  40.653  -16.099 1.000 64.155  0 61  GLU B CD  1 ? 
ATOM   1702 O  OE1 . GLU B 1 38  ? 21.306  40.763  -16.267 1.000 75.925  0 61  GLU B OE1 1 ? 
ATOM   1703 O  OE2 . GLU B 1 38  ? 19.249  41.493  -16.524 1.000 64.122  0 61  GLU B OE2 1 ? 
ATOM   1704 N  N   . GLY B 1 39  ? 17.750  38.304  -12.242 1.000 24.675  0 62  GLY B N   1 ? 
ATOM   1705 C  CA  . GLY B 1 39  ? 18.203  38.101  -10.878 1.000 25.345  0 62  GLY B CA  1 ? 
ATOM   1706 C  C   . GLY B 1 39  ? 18.071  36.646  -10.433 1.000 26.187  0 62  GLY B C   1 ? 
ATOM   1707 O  O   . GLY B 1 39  ? 18.995  36.125  -9.825  1.000 24.852  0 62  GLY B O   1 ? 
ATOM   1708 N  N   . LEU B 1 40  ? 16.923  36.021  -10.722 1.000 22.798  0 63  LEU B N   1 ? 
ATOM   1709 C  CA  . LEU B 1 40  ? 16.722  34.638  -10.322 1.000 22.960  0 63  LEU B CA  1 ? 
ATOM   1710 C  C   . LEU B 1 40  ? 17.737  33.728  -11.013 1.000 20.525  0 63  LEU B C   1 ? 
ATOM   1711 O  O   . LEU B 1 40  ? 18.274  32.798  -10.400 1.000 21.227  0 63  LEU B O   1 ? 
ATOM   1712 C  CB  . LEU B 1 40  ? 15.307  34.200  -10.704 1.000 25.071  0 63  LEU B CB  1 ? 
ATOM   1713 C  CG  . LEU B 1 40  ? 14.171  34.821  -9.903  1.000 27.173  0 63  LEU B CG  1 ? 
ATOM   1714 C  CD1 . LEU B 1 40  ? 12.830  34.278  -10.404 1.000 32.509  0 63  LEU B CD1 1 ? 
ATOM   1715 C  CD2 . LEU B 1 40  ? 14.326  34.550  -8.411  1.000 27.261  0 63  LEU B CD2 1 ? 
ATOM   1716 N  N   . LEU B 1 41  ? 17.942  33.939  -12.310 1.000 21.289  0 64  LEU B N   1 ? 
ATOM   1717 C  CA  . LEU B 1 41  ? 18.852  33.087  -13.056 1.000 24.271  0 64  LEU B CA  1 ? 
ATOM   1718 C  C   . LEU B 1 41  ? 20.303  33.253  -12.585 1.000 23.667  0 64  LEU B C   1 ? 
ATOM   1719 O  O   . LEU B 1 41  ? 21.039  32.281  -12.545 1.000 21.646  0 64  LEU B O   1 ? 
ATOM   1720 C  CB  . LEU B 1 41  ? 18.705  33.359  -14.545 1.000 25.689  0 64  LEU B CB  1 ? 
ATOM   1721 C  CG  . LEU B 1 41  ? 17.442  32.840  -15.209 1.000 25.520  0 64  LEU B CG  1 ? 
ATOM   1722 C  CD1 . LEU B 1 41  ? 17.255  33.559  -16.534 1.000 29.658  0 64  LEU B CD1 1 ? 
ATOM   1723 C  CD2 . LEU B 1 41  ? 17.551  31.317  -15.412 1.000 22.119  0 64  LEU B CD2 1 ? 
ATOM   1724 N  N   . ALA B 1 42  ? 20.699  34.468  -12.164 1.000 24.735  0 65  ALA B N   1 ? 
ATOM   1725 C  CA  . ALA B 1 42  ? 22.019  34.734  -11.608 1.000 24.891  0 65  ALA B CA  1 ? 
ATOM   1726 C  C   . ALA B 1 42  ? 22.212  34.037  -10.271 1.000 23.710  0 65  ALA B C   1 ? 
ATOM   1727 O  O   . ALA B 1 42  ? 23.254  33.412  -10.050 1.000 25.806  0 65  ALA B O   1 ? 
ATOM   1728 C  CB  . ALA B 1 42  ? 22.271  36.251  -11.485 1.000 26.481  0 65  ALA B CB  1 ? 
ATOM   1729 N  N   . THR B 1 43  ? 21.188  34.048  -9.437  1.000 21.870  0 66  THR B N   1 ? 
ATOM   1730 C  CA  . THR B 1 43  ? 21.234  33.389  -8.156  1.000 21.830  0 66  THR B CA  1 ? 
ATOM   1731 C  C   . THR B 1 43  ? 21.360  31.882  -8.375  1.000 23.070  0 66  THR B C   1 ? 
ATOM   1732 O  O   . THR B 1 43  ? 22.175  31.244  -7.718  1.000 22.513  0 66  THR B O   1 ? 
ATOM   1733 C  CB  . THR B 1 43  ? 20.015  33.763  -7.311  1.000 23.912  0 66  THR B CB  1 ? 
ATOM   1734 O  OG1 . THR B 1 43  ? 20.128  35.170  -7.026  1.000 24.316  0 66  THR B OG1 1 ? 
ATOM   1735 C  CG2 . THR B 1 43  ? 19.913  32.942  -6.057  1.000 24.681  0 66  THR B CG2 1 ? 
ATOM   1736 N  N   . PHE B 1 44  ? 20.575  31.367  -9.318  1.000 20.643  0 67  PHE B N   1 ? 
ATOM   1737 C  CA  . PHE B 1 44  ? 20.643  29.938  -9.627  1.000 19.237  0 67  PHE B CA  1 ? 
ATOM   1738 C  C   . PHE B 1 44  ? 22.034  29.565  -10.100 1.000 21.050  0 67  PHE B C   1 ? 
ATOM   1739 O  O   . PHE B 1 44  ? 22.576  28.514  -9.722  1.000 24.570  0 67  PHE B O   1 ? 
ATOM   1740 C  CB  . PHE B 1 44  ? 19.583  29.537  -10.649 1.000 21.653  0 67  PHE B CB  1 ? 
ATOM   1741 C  CG  . PHE B 1 44  ? 19.501  28.052  -10.856 1.000 20.812  0 67  PHE B CG  1 ? 
ATOM   1742 C  CD1 . PHE B 1 44  ? 20.341  27.429  -11.769 1.000 24.540  0 67  PHE B CD1 1 ? 
ATOM   1743 C  CD2 . PHE B 1 44  ? 18.640  27.277  -10.097 1.000 24.253  0 67  PHE B CD2 1 ? 
ATOM   1744 C  CE1 . PHE B 1 44  ? 20.271  26.050  -11.933 1.000 20.960  0 67  PHE B CE1 1 ? 
ATOM   1745 C  CE2 . PHE B 1 44  ? 18.607  25.895  -10.224 1.000 24.118  0 67  PHE B CE2 1 ? 
ATOM   1746 C  CZ  . PHE B 1 44  ? 19.413  25.294  -11.162 1.000 22.402  0 67  PHE B CZ  1 ? 
ATOM   1747 N  N   . LYS B 1 45  ? 22.619  30.390  -10.953 1.000 21.587  0 68  LYS B N   1 ? 
ATOM   1748 C  CA  . LYS B 1 45  ? 23.913  30.064  -11.520 1.000 24.655  0 68  LYS B CA  1 ? 
ATOM   1749 C  C   . LYS B 1 45  ? 24.958  29.973  -10.401 1.000 25.535  0 68  LYS B C   1 ? 
ATOM   1750 O  O   . LYS B 1 45  ? 25.711  28.996  -10.364 1.000 25.052  0 68  LYS B O   1 ? 
ATOM   1751 C  CB  . LYS B 1 45  ? 24.271  31.061  -12.621 1.000 30.070  0 68  LYS B CB  1 ? 
ATOM   1752 C  CG  . LYS B 1 45  ? 25.746  31.056  -12.978 1.000 39.508  0 68  LYS B CG  1 ? 
ATOM   1753 C  CD  . LYS B 1 45  ? 26.059  31.860  -14.209 1.000 50.006  0 68  LYS B CD  1 ? 
ATOM   1754 C  CE  . LYS B 1 45  ? 27.518  31.776  -14.617 1.000 56.571  0 68  LYS B CE  1 ? 
ATOM   1755 N  NZ  . LYS B 1 45  ? 27.648  31.806  -16.091 1.000 59.766  0 68  LYS B NZ  1 ? 
ATOM   1756 N  N   . GLU B 1 46  ? 24.988  30.949  -9.479  1.000 24.819  0 69  GLU B N   1 ? 
ATOM   1757 C  CA  . GLU B 1 46  ? 25.954  30.957  -8.391  1.000 27.032  0 69  GLU B CA  1 ? 
ATOM   1758 C  C   . GLU B 1 46  ? 25.700  29.850  -7.391  1.000 26.560  0 69  GLU B C   1 ? 
ATOM   1759 O  O   . GLU B 1 46  ? 26.645  29.172  -6.974  1.000 25.126  0 69  GLU B O   1 ? 
ATOM   1760 C  CB  . GLU B 1 46  ? 25.956  32.276  -7.626  1.000 30.745  0 69  GLU B CB  1 ? 
ATOM   1761 C  CG  . GLU B 1 46  ? 26.364  33.435  -8.499  1.000 34.518  0 69  GLU B CG  1 ? 
ATOM   1762 C  CD  . GLU B 1 46  ? 27.795  33.473  -9.020  1.000 39.581  0 69  GLU B CD  1 ? 
ATOM   1763 O  OE1 . GLU B 1 46  ? 28.684  32.725  -8.512  1.000 39.197  0 69  GLU B OE1 1 ? 
ATOM   1764 O  OE2 . GLU B 1 46  ? 28.040  34.294  -9.919  1.000 39.414  0 69  GLU B OE2 1 ? 
ATOM   1765 N  N   . LEU B 1 47  ? 24.434  29.650  -7.001  1.000 24.243  0 70  LEU B N   1 ? 
ATOM   1766 C  CA  . LEU B 1 47  ? 24.161  28.711  -5.946  1.000 24.851  0 70  LEU B CA  1 ? 
ATOM   1767 C  C   . LEU B 1 47  ? 24.267  27.283  -6.459  1.000 27.408  0 70  LEU B C   1 ? 
ATOM   1768 O  O   . LEU B 1 47  ? 24.585  26.375  -5.677  1.000 23.342  0 70  LEU B O   1 ? 
ATOM   1769 C  CB  . LEU B 1 47  ? 22.792  28.991  -5.337  1.000 26.853  0 70  LEU B CB  1 ? 
ATOM   1770 C  CG  . LEU B 1 47  ? 22.706  30.303  -4.573  1.000 26.349  0 70  LEU B CG  1 ? 
ATOM   1771 C  CD1 . LEU B 1 47  ? 21.355  30.455  -3.924  1.000 26.051  0 70  LEU B CD1 1 ? 
ATOM   1772 C  CD2 . LEU B 1 47  ? 23.820  30.403  -3.553  1.000 29.270  0 70  LEU B CD2 1 ? 
ATOM   1773 N  N   . SER B 1 48  ? 24.045  27.086  -7.758  1.000 24.636  0 71  SER B N   1 ? 
ATOM   1774 C  CA  . SER B 1 48  ? 24.198  25.733  -8.281  1.000 24.983  0 71  SER B CA  1 ? 
ATOM   1775 C  C   . SER B 1 48  ? 25.666  25.290  -8.174  1.000 28.066  0 71  SER B C   1 ? 
ATOM   1776 O  O   . SER B 1 48  ? 25.893  24.158  -7.778  1.000 24.458  0 71  SER B O   1 ? 
ATOM   1777 C  CB  . SER B 1 48  ? 23.627  25.610  -9.659  1.000 27.127  0 71  SER B CB  1 ? 
ATOM   1778 O  OG  . SER B 1 48  ? 24.358  26.352  -10.583 1.000 26.254  0 71  SER B OG  1 ? 
ATOM   1779 N  N   . ALA B 1 49  ? 26.639  26.192  -8.408  1.000 26.631  0 72  ALA B N   1 ? 
ATOM   1780 C  CA  . ALA B 1 49  ? 28.065  25.869  -8.300  1.000 28.293  0 72  ALA B CA  1 ? 
ATOM   1781 C  C   . ALA B 1 49  ? 28.466  25.636  -6.848  1.000 27.449  0 72  ALA B C   1 ? 
ATOM   1782 O  O   . ALA B 1 49  ? 29.433  24.954  -6.577  1.000 32.521  0 72  ALA B O   1 ? 
ATOM   1783 C  CB  . ALA B 1 49  ? 28.904  26.980  -8.892  1.000 29.473  0 72  ALA B CB  1 ? 
ATOM   1784 N  N   . ALA B 1 50  ? 27.709  26.183  -5.907  1.000 25.296  0 73  ALA B N   1 ? 
ATOM   1785 C  CA  . ALA B 1 50  ? 27.939  25.912  -4.495  1.000 28.052  0 73  ALA B CA  1 ? 
ATOM   1786 C  C   . ALA B 1 50  ? 27.391  24.536  -4.094  1.000 34.065  0 73  ALA B C   1 ? 
ATOM   1787 O  O   . ALA B 1 50  ? 27.660  24.086  -2.999  1.000 32.536  0 73  ALA B O   1 ? 
ATOM   1788 C  CB  . ALA B 1 50  ? 27.294  26.983  -3.662  1.000 29.869  0 73  ALA B CB  1 ? 
ATOM   1789 N  N   . ASN B 1 51  ? 26.595  23.879  -4.949  1.000 28.283  0 74  ASN B N   1 ? 
ATOM   1790 C  CA  . ASN B 1 51  ? 25.804  22.725  -4.529  1.000 27.857  0 74  ASN B CA  1 ? 
ATOM   1791 C  C   . ASN B 1 51  ? 26.055  21.550  -5.458  1.000 32.651  0 74  ASN B C   1 ? 
ATOM   1792 O  O   . ASN B 1 51  ? 25.209  20.659  -5.550  1.000 37.787  0 74  ASN B O   1 ? 
ATOM   1793 C  CB  . ASN B 1 51  ? 24.311  23.074  -4.426  1.000 31.194  0 74  ASN B CB  1 ? 
ATOM   1794 C  CG  . ASN B 1 51  ? 24.007  23.929  -3.216  1.000 30.593  0 74  ASN B CG  1 ? 
ATOM   1795 O  OD1 . ASN B 1 51  ? 23.852  23.394  -2.133  1.000 41.420  0 74  ASN B OD1 1 ? 
ATOM   1796 N  ND2 . ASN B 1 51  ? 23.962  25.238  -3.338  1.000 30.154  0 74  ASN B ND2 1 ? 
ATOM   1797 N  N   . ASN B 1 52  ? 27.216  21.553  -6.123  1.000 33.582  0 75  ASN B N   1 ? 
ATOM   1798 C  CA  . ASN B 1 52  ? 27.700  20.465  -6.967  1.000 38.512  0 75  ASN B CA  1 ? 
ATOM   1799 C  C   . ASN B 1 52  ? 26.717  20.143  -8.091  1.000 37.181  0 75  ASN B C   1 ? 
ATOM   1800 O  O   . ASN B 1 52  ? 26.536  18.988  -8.432  1.000 33.280  0 75  ASN B O   1 ? 
ATOM   1801 C  CB  . ASN B 1 52  ? 27.965  19.182  -6.172  1.000 43.927  0 75  ASN B CB  1 ? 
ATOM   1802 C  CG  . ASN B 1 52  ? 28.967  19.449  -5.072  1.000 55.785  0 75  ASN B CG  1 ? 
ATOM   1803 O  OD1 . ASN B 1 52  ? 30.113  19.796  -5.354  1.000 61.181  0 75  ASN B OD1 1 ? 
ATOM   1804 N  ND2 . ASN B 1 52  ? 28.520  19.378  -3.826  1.000 61.692  0 75  ASN B ND2 1 ? 
ATOM   1805 N  N   . TYR B 1 53  ? 26.073  21.160  -8.656  1.000 27.120  0 76  TYR B N   1 ? 
ATOM   1806 C  CA  . TYR B 1 53  ? 25.069  20.916  -9.675  1.000 26.361  0 76  TYR B CA  1 ? 
ATOM   1807 C  C   . TYR B 1 53  ? 25.732  20.512  -10.981 1.000 26.959  0 76  TYR B C   1 ? 
ATOM   1808 O  O   . TYR B 1 53  ? 26.716  21.091  -11.435 1.000 25.579  0 76  TYR B O   1 ? 
ATOM   1809 C  CB  . TYR B 1 53  ? 24.265  22.201  -9.830  1.000 25.049  0 76  TYR B CB  1 ? 
ATOM   1810 C  CG  . TYR B 1 53  ? 23.221  22.258  -10.923 1.000 23.977  0 76  TYR B CG  1 ? 
ATOM   1811 C  CD1 . TYR B 1 53  ? 21.943  21.774  -10.681 1.000 25.610  0 76  TYR B CD1 1 ? 
ATOM   1812 C  CD2 . TYR B 1 53  ? 23.513  22.765  -12.176 1.000 24.604  0 76  TYR B CD2 1 ? 
ATOM   1813 C  CE1 . TYR B 1 53  ? 20.961  21.829  -11.657 1.000 26.611  0 76  TYR B CE1 1 ? 
ATOM   1814 C  CE2 . TYR B 1 53  ? 22.528  22.840  -13.160 1.000 25.962  0 76  TYR B CE2 1 ? 
ATOM   1815 C  CZ  . TYR B 1 53  ? 21.255  22.348  -12.890 1.000 24.971  0 76  TYR B CZ  1 ? 
ATOM   1816 O  OH  . TYR B 1 53  ? 20.263  22.450  -13.807 1.000 30.698  0 76  TYR B OH  1 ? 
ATOM   1817 N  N   . LYS B 1 54  ? 25.092  19.568  -11.649 1.000 24.147  0 77  LYS B N   1 ? 
ATOM   1818 C  CA  . LYS B 1 54  ? 25.474  19.183  -12.981 1.000 25.793  0 77  LYS B CA  1 ? 
ATOM   1819 C  C   . LYS B 1 54  ? 24.405  19.570  -13.993 1.000 24.657  0 77  LYS B C   1 ? 
ATOM   1820 O  O   . LYS B 1 54  ? 24.702  20.236  -14.965 1.000 26.772  0 77  LYS B O   1 ? 
ATOM   1821 C  CB  . LYS B 1 54  ? 25.703  17.666  -13.015 1.000 32.745  0 77  LYS B CB  1 ? 
ATOM   1822 C  CG  . LYS B 1 54  ? 26.210  17.194  -14.368 1.000 43.319  0 77  LYS B CG  1 ? 
ATOM   1823 C  CD  . LYS B 1 54  ? 26.707  15.753  -14.450 1.000 52.963  0 77  LYS B CD  1 ? 
ATOM   1824 C  CE  . LYS B 1 54  ? 27.356  15.469  -15.793 1.000 58.219  0 77  LYS B CE  1 ? 
ATOM   1825 N  NZ  . LYS B 1 54  ? 27.729  14.039  -15.912 1.000 68.221  0 77  LYS B NZ  1 ? 
ATOM   1826 N  N   . ASP B 1 55  ? 23.203  19.014  -13.824 1.000 21.502  0 78  ASP B N   1 ? 
ATOM   1827 C  CA  . ASP B 1 55  ? 22.094  19.203  -14.735 1.000 23.009  0 78  ASP B CA  1 ? 
ATOM   1828 C  C   . ASP B 1 55  ? 20.801  18.947  -13.963 1.000 21.013  0 78  ASP B C   1 ? 
ATOM   1829 O  O   . ASP B 1 55  ? 20.830  18.566  -12.792 1.000 21.202  0 78  ASP B O   1 ? 
ATOM   1830 C  CB  . ASP B 1 55  ? 22.247  18.354  -15.985 1.000 27.360  0 78  ASP B CB  1 ? 
ATOM   1831 C  CG  . ASP B 1 55  ? 22.467  16.881  -15.694 1.000 30.594  0 78  ASP B CG  1 ? 
ATOM   1832 O  OD1 . ASP B 1 55  ? 21.764  16.352  -14.871 1.000 29.157  0 78  ASP B OD1 1 ? 
ATOM   1833 O  OD2 . ASP B 1 55  ? 23.361  16.293  -16.301 1.000 32.006  0 78  ASP B OD2 1 ? 
ATOM   1834 N  N   . VAL B 1 56  ? 19.676  19.279  -14.595 1.000 20.233  0 79  VAL B N   1 ? 
ATOM   1835 C  CA  . VAL B 1 56  ? 18.392  19.220  -13.899 1.000 20.406  0 79  VAL B CA  1 ? 
ATOM   1836 C  C   . VAL B 1 56  ? 18.051  17.767  -13.590 1.000 20.129  0 79  VAL B C   1 ? 
ATOM   1837 O  O   . VAL B 1 56  ? 17.561  17.438  -12.500 1.000 20.789  0 79  VAL B O   1 ? 
ATOM   1838 C  CB  . VAL B 1 56  ? 17.251  19.869  -14.700 1.000 22.496  0 79  VAL B CB  1 ? 
ATOM   1839 C  CG1 . VAL B 1 56  ? 15.967  19.765  -13.900 1.000 21.966  0 79  VAL B CG1 1 ? 
ATOM   1840 C  CG2 . VAL B 1 56  ? 17.543  21.320  -15.050 1.000 26.229  0 79  VAL B CG2 1 ? 
ATOM   1841 N  N   . ARG B 1 57  ? 18.360  16.890  -14.531 1.000 18.567  0 80  ARG B N   1 ? 
ATOM   1842 C  CA  . ARG B 1 57  ? 18.042  15.469  -14.339 1.000 20.848  0 80  ARG B CA  1 ? 
ATOM   1843 C  C   . ARG B 1 57  ? 18.791  14.921  -13.123 1.000 20.765  0 80  ARG B C   1 ? 
ATOM   1844 O  O   . ARG B 1 57  ? 18.202  14.238  -12.292 1.000 21.564  0 80  ARG B O   1 ? 
ATOM   1845 C  CB  . ARG B 1 57  ? 18.329  14.655  -15.602 1.000 21.313  0 80  ARG B CB  1 ? 
ATOM   1846 C  CG  . ARG B 1 57  ? 18.145  13.164  -15.348 1.000 21.678  0 80  ARG B CG  1 ? 
ATOM   1847 C  CD  . ARG B 1 57  ? 18.350  12.359  -16.621 1.000 21.774  0 80  ARG B CD  1 ? 
ATOM   1848 N  NE  . ARG B 1 57  ? 17.794  11.021  -16.399 1.000 21.831  0 80  ARG B NE  1 ? 
ATOM   1849 C  CZ  . ARG B 1 57  ? 17.803  10.099  -17.339 1.000 26.074  0 80  ARG B CZ  1 ? 
ATOM   1850 N  NH1 . ARG B 1 57  ? 18.396  10.366  -18.493 1.000 26.591  0 80  ARG B NH1 1 ? 
ATOM   1851 N  NH2 . ARG B 1 57  ? 17.222  8.932   -17.108 1.000 27.865  0 80  ARG B NH2 1 ? 
ATOM   1852 N  N   . SER B 1 58  ? 20.079  15.247  -12.963 1.000 21.495  0 81  SER B N   1 ? 
ATOM   1853 C  CA  . SER B 1 58  ? 20.882  14.742  -11.862 1.000 22.964  0 81  SER B CA  1 ? 
ATOM   1854 C  C   . SER B 1 58  ? 20.384  15.332  -10.551 1.000 23.910  0 81  SER B C   1 ? 
ATOM   1855 O  O   . SER B 1 58  ? 20.538  14.711  -9.514  1.000 23.332  0 81  SER B O   1 ? 
ATOM   1856 C  CB  . SER B 1 58  ? 22.374  15.081  -12.013 1.000 27.485  0 81  SER B CB  1 ? 
ATOM   1857 O  OG  . SER B 1 58  ? 22.878  14.569  -13.219 1.000 39.391  0 81  SER B OG  1 ? 
ATOM   1858 N  N   . LEU B 1 59  ? 19.861  16.556  -10.600 1.000 21.672  0 82  LEU B N   1 ? 
ATOM   1859 C  CA  . LEU B 1 59  ? 19.301  17.194  -9.425  1.000 21.006  0 82  LEU B CA  1 ? 
ATOM   1860 C  C   . LEU B 1 59  ? 18.015  16.505  -8.963  1.000 21.900  0 82  LEU B C   1 ? 
ATOM   1861 O  O   . LEU B 1 59  ? 17.898  16.217  -7.769  1.000 22.122  0 82  LEU B O   1 ? 
ATOM   1862 C  CB  . LEU B 1 59  ? 19.072  18.686  -9.702  1.000 21.985  0 82  LEU B CB  1 ? 
ATOM   1863 C  CG  . LEU B 1 59  ? 18.433  19.438  -8.544  1.000 22.600  0 82  LEU B CG  1 ? 
ATOM   1864 C  CD1 . LEU B 1 59  ? 19.433  19.604  -7.413  1.000 25.851  0 82  LEU B CD1 1 ? 
ATOM   1865 C  CD2 . LEU B 1 59  ? 17.920  20.798  -8.999  1.000 28.704  0 82  LEU B CD2 1 ? 
ATOM   1866 N  N   . MET B 1 60  ? 17.093  16.185  -9.889  1.000 20.873  0 83  MET B N   1 ? 
ATOM   1867 C  CA  . MET B 1 60  ? 15.743  15.704  -9.576  1.000 20.159  0 83  MET B CA  1 ? 
ATOM   1868 C  C   . MET B 1 60  ? 15.685  14.187  -9.362  1.000 22.917  0 83  MET B C   1 ? 
ATOM   1869 O  O   . MET B 1 60  ? 15.070  13.707  -8.399  1.000 22.788  0 83  MET B O   1 ? 
ATOM   1870 C  CB  . MET B 1 60  ? 14.789  16.066  -10.717 1.000 20.414  0 83  MET B CB  1 ? 
ATOM   1871 C  CG  . MET B 1 60  ? 14.577  17.577  -10.800 1.000 22.332  0 83  MET B CG  1 ? 
ATOM   1872 S  SD  . MET B 1 60  ? 13.156  17.903  -11.767 1.000 25.391  0 83  MET B SD  1 ? 
ATOM   1873 C  CE  . MET B 1 60  ? 13.208  19.701  -11.814 1.000 24.566  0 83  MET B CE  1 ? 
ATOM   1874 N  N   . ASP B 1 61  ? 16.384  13.439  -10.219 1.000 21.841  0 84  ASP B N   1 ? 
ATOM   1875 C  CA  . ASP B 1 61  ? 16.246  11.971  -10.208 1.000 23.603  0 84  ASP B CA  1 ? 
ATOM   1876 C  C   . ASP B 1 61  ? 16.700  11.409  -8.867  1.000 24.069  0 84  ASP B C   1 ? 
ATOM   1877 O  O   . ASP B 1 61  ? 17.817  11.667  -8.415  1.000 24.091  0 84  ASP B O   1 ? 
ATOM   1878 C  CB  . ASP B 1 61  ? 17.082  11.278  -11.291 1.000 23.888  0 84  ASP B CB  1 ? 
ATOM   1879 C  CG  . ASP B 1 61  ? 16.462  11.215  -12.684 1.000 30.575  0 84  ASP B CG  1 ? 
ATOM   1880 O  OD1 . ASP B 1 61  ? 15.342  11.771  -12.884 1.000 29.084  0 84  ASP B OD1 1 ? 
ATOM   1881 O  OD2 . ASP B 1 61  ? 17.157  10.636  -13.600 1.000 32.051  0 84  ASP B OD2 1 ? 
ATOM   1882 N  N   . GLY B 1 62  ? 15.826  10.610  -8.226  1.000 23.752  0 85  GLY B N   1 ? 
ATOM   1883 C  CA  . GLY B 1 62  ? 16.232  9.954   -7.004  1.000 23.943  0 85  GLY B CA  1 ? 
ATOM   1884 C  C   . GLY B 1 62  ? 15.963  10.770  -5.751  1.000 24.290  0 85  GLY B C   1 ? 
ATOM   1885 O  O   . GLY B 1 62  ? 16.185  10.266  -4.660  1.000 20.846  0 85  GLY B O   1 ? 
ATOM   1886 N  N   . ASN B 1 63  ? 15.512  12.033  -5.893  1.000 21.273  0 86  ASN B N   1 ? 
ATOM   1887 C  CA  . ASN B 1 63  ? 15.212  12.848  -4.735  1.000 22.301  0 86  ASN B CA  1 ? 
ATOM   1888 C  C   . ASN B 1 63  ? 13.722  13.109  -4.688  1.000 21.273  0 86  ASN B C   1 ? 
ATOM   1889 O  O   . ASN B 1 63  ? 13.173  13.842  -5.516  1.000 21.057  0 86  ASN B O   1 ? 
ATOM   1890 C  CB  . ASN B 1 63  ? 16.005  14.155  -4.759  1.000 23.747  0 86  ASN B CB  1 ? 
ATOM   1891 C  CG  . ASN B 1 63  ? 15.768  14.961  -3.504  1.000 25.120  0 86  ASN B CG  1 ? 
ATOM   1892 O  OD1 . ASN B 1 63  ? 14.784  14.733  -2.781  1.000 22.699  0 86  ASN B OD1 1 ? 
ATOM   1893 N  ND2 . ASN B 1 63  ? 16.644  15.932  -3.265  1.000 25.802  0 86  ASN B ND2 1 ? 
ATOM   1894 N  N   . PRO B 1 64  ? 12.977  12.475  -3.755  1.000 21.196  0 87  PRO B N   1 ? 
ATOM   1895 C  CA  . PRO B 1 64  ? 11.526  12.598  -3.726  1.000 22.206  0 87  PRO B CA  1 ? 
ATOM   1896 C  C   . PRO B 1 64  ? 10.956  13.997  -3.505  1.000 20.954  0 87  PRO B C   1 ? 
ATOM   1897 O  O   . PRO B 1 64  ? 9.790   14.180  -3.759  1.000 21.368  0 87  PRO B O   1 ? 
ATOM   1898 C  CB  . PRO B 1 64  ? 11.039  11.668  -2.596  1.000 23.838  0 87  PRO B CB  1 ? 
ATOM   1899 C  CG  . PRO B 1 64  ? 12.249  10.926  -2.143  1.000 25.110  0 87  PRO B CG  1 ? 
ATOM   1900 C  CD  . PRO B 1 64  ? 13.493  11.574  -2.709  1.000 24.810  0 87  PRO B CD  1 ? 
ATOM   1901 N  N   A VAL B 1 65  ? 11.765  14.983  -3.085  0.500 21.717  0 88  VAL B N   1 ? 
ATOM   1902 N  N   B VAL B 1 65  ? 11.780  14.965  -3.111  0.500 20.650  0 88  VAL B N   1 ? 
ATOM   1903 C  CA  A VAL B 1 65  ? 11.254  16.348  -2.948  0.500 21.603  0 88  VAL B CA  1 ? 
ATOM   1904 C  CA  B VAL B 1 65  ? 11.287  16.325  -2.930  0.500 20.011  0 88  VAL B CA  1 ? 
ATOM   1905 C  C   A VAL B 1 65  ? 10.753  16.844  -4.302  0.500 20.244  0 88  VAL B C   1 ? 
ATOM   1906 C  C   B VAL B 1 65  ? 10.914  16.950  -4.279  0.500 19.447  0 88  VAL B C   1 ? 
ATOM   1907 O  O   A VAL B 1 65  ? 9.817   17.638  -4.358  0.500 18.394  0 88  VAL B O   1 ? 
ATOM   1908 O  O   B VAL B 1 65  ? 10.208  17.951  -4.308  0.500 19.012  0 88  VAL B O   1 ? 
ATOM   1909 C  CB  A VAL B 1 65  ? 12.259  17.358  -2.360  0.500 23.945  0 88  VAL B CB  1 ? 
ATOM   1910 C  CB  B VAL B 1 65  ? 12.292  17.182  -2.147  0.500 20.548  0 88  VAL B CB  1 ? 
ATOM   1911 C  CG1 A VAL B 1 65  ? 13.042  16.792  -1.195  0.500 24.716  0 88  VAL B CG1 1 ? 
ATOM   1912 C  CG1 B VAL B 1 65  ? 13.551  17.466  -2.927  0.500 21.741  0 88  VAL B CG1 1 ? 
ATOM   1913 C  CG2 A VAL B 1 65  ? 13.193  17.950  -3.403  0.500 25.979  0 88  VAL B CG2 1 ? 
ATOM   1914 C  CG2 B VAL B 1 65  ? 11.651  18.482  -1.692  0.500 20.044  0 88  VAL B CG2 1 ? 
ATOM   1915 N  N   . TYR B 1 66  ? 11.340  16.340  -5.394  1.000 20.680  0 89  TYR B N   1 ? 
ATOM   1916 C  CA  . TYR B 1 66  ? 10.970  16.782  -6.743  1.000 20.163  0 89  TYR B CA  1 ? 
ATOM   1917 C  C   . TYR B 1 66  ? 9.750   16.044  -7.302  1.000 21.640  0 89  TYR B C   1 ? 
ATOM   1918 O  O   . TYR B 1 66  ? 9.325   16.269  -8.442  1.000 23.713  0 89  TYR B O   1 ? 
ATOM   1919 C  CB  . TYR B 1 66  ? 12.164  16.722  -7.683  1.000 22.379  0 89  TYR B CB  1 ? 
ATOM   1920 C  CG  . TYR B 1 66  ? 13.260  17.682  -7.251  1.000 21.100  0 89  TYR B CG  1 ? 
ATOM   1921 C  CD1 . TYR B 1 66  ? 13.175  19.050  -7.498  1.000 22.219  0 89  TYR B CD1 1 ? 
ATOM   1922 C  CD2 . TYR B 1 66  ? 14.351  17.237  -6.546  1.000 21.157  0 89  TYR B CD2 1 ? 
ATOM   1923 C  CE1 . TYR B 1 66  ? 14.182  19.906  -7.087  1.000 20.806  0 89  TYR B CE1 1 ? 
ATOM   1924 C  CE2 . TYR B 1 66  ? 15.340  18.092  -6.094  1.000 20.392  0 89  TYR B CE2 1 ? 
ATOM   1925 C  CZ  . TYR B 1 66  ? 15.247  19.453  -6.363  1.000 21.135  0 89  TYR B CZ  1 ? 
ATOM   1926 O  OH  . TYR B 1 66  ? 16.265  20.226  -5.909  1.000 23.559  0 89  TYR B OH  1 ? 
ATOM   1927 N  N   . GLY B 1 67  ? 9.157   15.193  -6.488  1.000 22.021  0 90  GLY B N   1 ? 
ATOM   1928 C  CA  . GLY B 1 67  ? 7.942   14.490  -6.842  1.000 21.758  0 90  GLY B CA  1 ? 
ATOM   1929 C  C   . GLY B 1 67  ? 8.201   13.223  -7.641  1.000 22.525  0 90  GLY B C   1 ? 
ATOM   1930 O  O   . GLY B 1 67  ? 9.347   12.842  -7.884  1.000 21.954  0 90  GLY B O   1 ? 
ATOM   1931 N  N   . GLU B 1 68  ? 7.105   12.594  -8.084  1.000 24.217  0 91  GLU B N   1 ? 
ATOM   1932 C  CA  . GLU B 1 68  ? 7.211   11.284  -8.711  1.000 30.379  0 91  GLU B CA  1 ? 
ATOM   1933 C  C   . GLU B 1 68  ? 7.976   11.356  -10.041 1.000 28.703  0 91  GLU B C   1 ? 
ATOM   1934 O  O   . GLU B 1 68  ? 7.928   12.332  -10.774 1.000 26.379  0 91  GLU B O   1 ? 
ATOM   1935 C  CB  . GLU B 1 68  ? 5.810   10.694  -8.926  1.000 31.778  0 91  GLU B CB  1 ? 
ATOM   1936 C  CG  . GLU B 1 68  ? 4.936   11.441  -9.927  1.000 37.636  0 91  GLU B CG  1 ? 
ATOM   1937 C  CD  . GLU B 1 68  ? 3.512   10.884  -10.079 1.000 49.025  0 91  GLU B CD  1 ? 
ATOM   1938 O  OE1 . GLU B 1 68  ? 3.386   9.633   -10.060 1.000 47.988  0 91  GLU B OE1 1 ? 
ATOM   1939 O  OE2 . GLU B 1 68  ? 2.523   11.695  -10.289 1.000 46.350  0 91  GLU B OE2 1 ? 
ATOM   1940 N  N   . ASP B 1 69  ? 8.685   10.285  -10.386 1.000 28.012  0 92  ASP B N   1 ? 
ATOM   1941 C  CA  . ASP B 1 69  ? 9.295   10.174  -11.707 1.000 31.003  0 92  ASP B CA  1 ? 
ATOM   1942 C  C   . ASP B 1 69  ? 8.220   10.320  -12.781 1.000 29.474  0 92  ASP B C   1 ? 
ATOM   1943 O  O   . ASP B 1 69  ? 7.091   9.905   -12.555 1.000 30.292  0 92  ASP B O   1 ? 
ATOM   1944 C  CB  . ASP B 1 69  ? 10.003  8.830   -11.870 1.000 31.622  0 92  ASP B CB  1 ? 
ATOM   1945 C  CG  . ASP B 1 69  ? 11.252  8.709   -11.008 1.000 39.679  0 92  ASP B CG  1 ? 
ATOM   1946 O  OD1 . ASP B 1 69  ? 12.207  9.551   -11.138 1.000 43.776  0 92  ASP B OD1 1 ? 
ATOM   1947 O  OD2 . ASP B 1 69  ? 11.298  7.746   -10.247 1.000 39.308  0 92  ASP B OD2 1 ? 
ATOM   1948 N  N   A CYS B 1 70  ? 8.582   10.966  -13.906 0.700 27.220  0 93  CYS B N   1 ? 
ATOM   1949 N  N   B CYS B 1 70  ? 8.562   10.956  -13.914 0.300 28.168  0 93  CYS B N   1 ? 
ATOM   1950 C  CA  A CYS B 1 70  ? 7.719   11.106  -15.071 0.700 26.181  0 93  CYS B CA  1 ? 
ATOM   1951 C  CA  B CYS B 1 70  ? 7.676   11.073  -15.067 0.300 27.374  0 93  CYS B CA  1 ? 
ATOM   1952 C  C   A CYS B 1 70  ? 6.505   12.019  -14.836 0.700 25.632  0 93  CYS B C   1 ? 
ATOM   1953 C  C   B CYS B 1 70  ? 6.541   12.081  -14.857 0.300 26.042  0 93  CYS B C   1 ? 
ATOM   1954 O  O   A CYS B 1 70  ? 5.704   12.223  -15.743 0.700 23.637  0 93  CYS B O   1 ? 
ATOM   1955 O  O   B CYS B 1 70  ? 5.810   12.380  -15.797 0.300 24.892  0 93  CYS B O   1 ? 
ATOM   1956 C  CB  A CYS B 1 70  ? 7.262   9.736   -15.568 0.700 27.679  0 93  CYS B CB  1 ? 
ATOM   1957 C  CB  B CYS B 1 70  ? 7.028   9.741   -15.428 0.300 28.801  0 93  CYS B CB  1 ? 
ATOM   1958 S  SG  A CYS B 1 70  ? 8.639   8.718   -16.142 0.700 30.496  0 93  CYS B SG  1 ? 
ATOM   1959 S  SG  B CYS B 1 70  ? 8.106   8.312   -15.179 0.300 29.375  0 93  CYS B SG  1 ? 
ATOM   1960 N  N   . GLY B 1 71  ? 6.367   12.595  -13.634 1.000 24.433  0 94  GLY B N   1 ? 
ATOM   1961 C  CA  . GLY B 1 71  ? 5.275   13.506  -13.374 1.000 24.020  0 94  GLY B CA  1 ? 
ATOM   1962 C  C   . GLY B 1 71  ? 3.923   12.825  -13.608 1.000 25.229  0 94  GLY B C   1 ? 
ATOM   1963 O  O   . GLY B 1 71  ? 3.701   11.688  -13.167 1.000 26.836  0 94  GLY B O   1 ? 
ATOM   1964 N  N   . PHE B 1 72  ? 3.084   13.507  -14.374 1.000 24.569  0 95  PHE B N   1 ? 
ATOM   1965 C  CA  . PHE B 1 72  ? 1.751   13.004  -14.678 1.000 26.062  0 95  PHE B CA  1 ? 
ATOM   1966 C  C   . PHE B 1 72  ? 1.722   12.137  -15.939 1.000 27.568  0 95  PHE B C   1 ? 
ATOM   1967 O  O   . PHE B 1 72  ? 0.663   11.590  -16.239 1.000 27.517  0 95  PHE B O   1 ? 
ATOM   1968 C  CB  . PHE B 1 72  ? 0.780   14.169  -14.830 1.000 25.111  0 95  PHE B CB  1 ? 
ATOM   1969 C  CG  . PHE B 1 72  ? 0.642   14.968  -13.569 1.000 30.469  0 95  PHE B CG  1 ? 
ATOM   1970 C  CD1 . PHE B 1 72  ? -0.112  14.472  -12.512 1.000 33.331  0 95  PHE B CD1 1 ? 
ATOM   1971 C  CD2 . PHE B 1 72  ? 1.232   16.216  -13.451 1.000 28.537  0 95  PHE B CD2 1 ? 
ATOM   1972 C  CE1 . PHE B 1 72  ? -0.257  15.205  -11.345 1.000 35.352  0 95  PHE B CE1 1 ? 
ATOM   1973 C  CE2 . PHE B 1 72  ? 1.107   16.940  -12.267 1.000 31.653  0 95  PHE B CE2 1 ? 
ATOM   1974 C  CZ  . PHE B 1 72  ? 0.358   16.433  -11.226 1.000 34.454  0 95  PHE B CZ  1 ? 
ATOM   1975 N  N   . THR B 1 73  ? 2.855   12.003  -16.668 1.000 22.951  0 96  THR B N   1 ? 
ATOM   1976 C  CA  . THR B 1 73  ? 2.918   11.256  -17.907 1.000 24.366  0 96  THR B CA  1 ? 
ATOM   1977 C  C   . THR B 1 73  ? 3.128   9.786   -17.581 1.000 26.822  0 96  THR B C   1 ? 
ATOM   1978 O  O   . THR B 1 73  ? 3.606   9.459   -16.499 1.000 29.283  0 96  THR B O   1 ? 
ATOM   1979 C  CB  . THR B 1 73  ? 4.001   11.781  -18.878 1.000 26.394  0 96  THR B CB  1 ? 
ATOM   1980 O  OG1 . THR B 1 73  ? 5.287   11.640  -18.277 1.000 27.086  0 96  THR B OG1 1 ? 
ATOM   1981 C  CG2 . THR B 1 73  ? 3.816   13.231  -19.251 1.000 25.080  0 96  THR B CG2 1 ? 
ATOM   1982 N  N   . ASP B 1 74  ? 2.798   8.912   -18.540 1.000 27.654  0 97  ASP B N   1 ? 
ATOM   1983 C  CA  . ASP B 1 74  ? 2.903   7.474   -18.363 1.000 28.930  0 97  ASP B CA  1 ? 
ATOM   1984 C  C   . ASP B 1 74  ? 4.070   6.874   -19.147 1.000 27.663  0 97  ASP B C   1 ? 
ATOM   1985 O  O   . ASP B 1 74  ? 4.035   6.755   -20.367 1.000 33.974  0 97  ASP B O   1 ? 
ATOM   1986 C  CB  . ASP B 1 74  ? 1.569   6.825   -18.730 1.000 32.674  0 97  ASP B CB  1 ? 
ATOM   1987 C  CG  . ASP B 1 74  ? 1.523   5.332   -18.469 1.000 39.515  0 97  ASP B CG  1 ? 
ATOM   1988 O  OD1 . ASP B 1 74  ? 2.541   4.759   -17.983 1.000 34.558  0 97  ASP B OD1 1 ? 
ATOM   1989 O  OD2 . ASP B 1 74  ? 0.483   4.738   -18.831 1.000 37.729  0 97  ASP B OD2 1 ? 
ATOM   1990 N  N   . PRO B 1 75  ? 5.148   6.405   -18.485 1.000 27.597  0 98  PRO B N   1 ? 
ATOM   1991 C  CA  . PRO B 1 75  ? 6.274   5.807   -19.189 1.000 28.075  0 98  PRO B CA  1 ? 
ATOM   1992 C  C   . PRO B 1 75  ? 5.871   4.492   -19.864 1.000 32.036  0 98  PRO B C   1 ? 
ATOM   1993 O  O   . PRO B 1 75  ? 6.572   4.011   -20.720 1.000 35.358  0 98  PRO B O   1 ? 
ATOM   1994 C  CB  . PRO B 1 75  ? 7.324   5.556   -18.089 1.000 29.605  0 98  PRO B CB  1 ? 
ATOM   1995 C  CG  . PRO B 1 75  ? 6.513   5.482   -16.801 1.000 29.343  0 98  PRO B CG  1 ? 
ATOM   1996 C  CD  . PRO B 1 75  ? 5.344   6.408   -17.022 1.000 27.719  0 98  PRO B CD  1 ? 
ATOM   1997 N  N   . LYS B 1 76  ? 4.757   3.915   -19.450 1.000 33.681  0 99  LYS B N   1 ? 
ATOM   1998 C  CA  . LYS B 1 76  ? 4.356   2.596   -19.926 1.000 37.244  0 99  LYS B CA  1 ? 
ATOM   1999 C  C   . LYS B 1 76  ? 3.365   2.700   -21.082 1.000 35.004  0 99  LYS B C   1 ? 
ATOM   2000 O  O   . LYS B 1 76  ? 2.894   1.682   -21.589 1.000 38.572  0 99  LYS B O   1 ? 
ATOM   2001 C  CB  . LYS B 1 76  ? 3.774   1.812   -18.740 1.000 38.961  0 99  LYS B CB  1 ? 
ATOM   2002 C  CG  . LYS B 1 76  ? 4.791   1.267   -17.755 1.000 46.264  0 99  LYS B CG  1 ? 
ATOM   2003 C  CD  . LYS B 1 76  ? 5.458   -0.017  -18.236 1.000 61.588  0 99  LYS B CD  1 ? 
ATOM   2004 C  CE  . LYS B 1 76  ? 5.364   -1.156  -17.232 1.000 74.626  0 99  LYS B CE  1 ? 
ATOM   2005 N  NZ  . LYS B 1 76  ? 6.284   -2.280  -17.545 1.000 78.629  0 99  LYS B NZ  1 ? 
ATOM   2006 N  N   . GLY B 1 77  ? 3.076   3.928   -21.522 1.000 32.525  0 100 GLY B N   1 ? 
ATOM   2007 C  CA  . GLY B 1 77  ? 2.198   4.168   -22.647 1.000 32.429  0 100 GLY B CA  1 ? 
ATOM   2008 C  C   . GLY B 1 77  ? 2.755   3.583   -23.943 1.000 32.734  0 100 GLY B C   1 ? 
ATOM   2009 O  O   . GLY B 1 77  ? 3.938   3.286   -24.088 1.000 33.381  0 100 GLY B O   1 ? 
ATOM   2010 N  N   . LYS B 1 78  ? 1.865   3.410   -24.907 1.000 36.173  0 101 LYS B N   1 ? 
ATOM   2011 C  CA  . LYS B 1 78  ? 2.253   2.939   -26.220 1.000 38.449  0 101 LYS B CA  1 ? 
ATOM   2012 C  C   . LYS B 1 78  ? 3.272   3.890   -26.857 1.000 34.310  0 101 LYS B C   1 ? 
ATOM   2013 O  O   . LYS B 1 78  ? 2.998   5.086   -26.959 1.000 36.982  0 101 LYS B O   1 ? 
ATOM   2014 C  CB  . LYS B 1 78  ? 0.997   2.873   -27.090 1.000 44.347  0 101 LYS B CB  1 ? 
ATOM   2015 C  CG  . LYS B 1 78  ? 1.244   2.355   -28.497 1.000 52.586  0 101 LYS B CG  1 ? 
ATOM   2016 C  CD  . LYS B 1 78  ? -0.024  2.035   -29.229 1.000 53.390  0 101 LYS B CD  1 ? 
ATOM   2017 C  CE  . LYS B 1 78  ? 0.256   1.483   -30.609 1.000 54.568  0 101 LYS B CE  1 ? 
ATOM   2018 N  NZ  . LYS B 1 78  ? -1.018  1.166   -31.290 1.000 54.421  0 101 LYS B NZ  1 ? 
ATOM   2019 N  N   . PRO B 1 79  ? 4.439   3.395   -27.327 1.000 31.195  0 102 PRO B N   1 ? 
ATOM   2020 C  CA  . PRO B 1 79  ? 5.476   4.264   -27.882 1.000 34.316  0 102 PRO B CA  1 ? 
ATOM   2021 C  C   . PRO B 1 79  ? 5.022   4.919   -29.176 1.000 35.024  0 102 PRO B C   1 ? 
ATOM   2022 O  O   . PRO B 1 79  ? 4.291   4.284   -29.929 1.000 33.335  0 102 PRO B O   1 ? 
ATOM   2023 C  CB  . PRO B 1 79  ? 6.686   3.361   -28.123 1.000 31.751  0 102 PRO B CB  1 ? 
ATOM   2024 C  CG  . PRO B 1 79  ? 6.312   1.983   -27.629 1.000 40.201  0 102 PRO B CG  1 ? 
ATOM   2025 C  CD  . PRO B 1 79  ? 4.827   1.978   -27.371 1.000 35.148  0 102 PRO B CD  1 ? 
ATOM   2026 N  N   . VAL B 1 80  ? 5.465   6.164   -29.406 1.000 31.103  0 103 VAL B N   1 ? 
ATOM   2027 C  CA  . VAL B 1 80  ? 5.124   6.923   -30.597 1.000 28.853  0 103 VAL B CA  1 ? 
ATOM   2028 C  C   . VAL B 1 80  ? 6.378   7.176   -31.431 1.000 30.988  0 103 VAL B C   1 ? 
ATOM   2029 O  O   . VAL B 1 80  ? 7.515   7.133   -30.958 1.000 27.540  0 103 VAL B O   1 ? 
ATOM   2030 C  CB  . VAL B 1 80  ? 4.423   8.244   -30.243 1.000 32.698  0 103 VAL B CB  1 ? 
ATOM   2031 C  CG1 . VAL B 1 80  ? 3.164   8.008   -29.428 1.000 35.355  0 103 VAL B CG1 1 ? 
ATOM   2032 C  CG2 . VAL B 1 80  ? 5.338   9.266   -29.563 1.000 29.001  0 103 VAL B CG2 1 ? 
ATOM   2033 N  N   . ALA B 1 81  ? 6.171   7.458   -32.714 1.000 33.890  0 104 ALA B N   1 ? 
ATOM   2034 C  CA  . ALA B 1 81  ? 7.281   7.790   -33.577 1.000 34.437  0 104 ALA B CA  1 ? 
ATOM   2035 C  C   . ALA B 1 81  ? 7.709   9.222   -33.294 1.000 33.430  0 104 ALA B C   1 ? 
ATOM   2036 O  O   . ALA B 1 81  ? 6.885   10.120  -33.232 1.000 33.562  0 104 ALA B O   1 ? 
ATOM   2037 C  CB  . ALA B 1 81  ? 6.868   7.636   -35.024 1.000 38.996  0 104 ALA B CB  1 ? 
ATOM   2038 N  N   . PRO B 1 82  ? 9.005   9.533   -33.182 1.000 33.107  0 105 PRO B N   1 ? 
ATOM   2039 C  CA  . PRO B 1 82  ? 9.390   10.930  -33.013 1.000 37.335  0 105 PRO B CA  1 ? 
ATOM   2040 C  C   . PRO B 1 82  ? 9.156   11.792  -34.245 1.000 34.623  0 105 PRO B C   1 ? 
ATOM   2041 O  O   . PRO B 1 82  ? 9.129   11.293  -35.354 1.000 34.959  0 105 PRO B O   1 ? 
ATOM   2042 C  CB  . PRO B 1 82  ? 10.895  10.876  -32.715 1.000 38.507  0 105 PRO B CB  1 ? 
ATOM   2043 C  CG  . PRO B 1 82  ? 11.345  9.542   -33.272 1.000 37.377  0 105 PRO B CG  1 ? 
ATOM   2044 C  CD  . PRO B 1 82  ? 10.147  8.614   -33.166 1.000 36.293  0 105 PRO B CD  1 ? 
ATOM   2045 N  N   . PRO B 1 83  ? 9.064   13.124  -34.076 1.000 35.637  0 106 PRO B N   1 ? 
ATOM   2046 C  CA  . PRO B 1 83  ? 9.031   14.054  -35.203 1.000 34.134  0 106 PRO B CA  1 ? 
ATOM   2047 C  C   . PRO B 1 83  ? 10.204  13.800  -36.169 1.000 31.544  0 106 PRO B C   1 ? 
ATOM   2048 O  O   . PRO B 1 83  ? 11.239  13.289  -35.761 1.000 32.495  0 106 PRO B O   1 ? 
ATOM   2049 C  CB  . PRO B 1 83  ? 9.132   15.436  -34.515 1.000 36.700  0 106 PRO B CB  1 ? 
ATOM   2050 C  CG  . PRO B 1 83  ? 8.643   15.209  -33.086 1.000 34.715  0 106 PRO B CG  1 ? 
ATOM   2051 C  CD  . PRO B 1 83  ? 9.052   13.798  -32.761 1.000 34.040  0 106 PRO B CD  1 ? 
ATOM   2052 N  N   A THR B 1 84  ? 10.027  14.160  -37.446 0.500 32.178  0 107 THR B N   1 ? 
ATOM   2053 N  N   B THR B 1 84  ? 10.011  14.168  -37.443 0.500 34.447  0 107 THR B N   1 ? 
ATOM   2054 C  CA  A THR B 1 84  ? 11.006  13.888  -38.484 0.500 32.253  0 107 THR B CA  1 ? 
ATOM   2055 C  CA  B THR B 1 84  ? 10.968  13.909  -38.505 0.500 36.617  0 107 THR B CA  1 ? 
ATOM   2056 C  C   A THR B 1 84  ? 11.766  15.169  -38.843 0.500 33.020  0 107 THR B C   1 ? 
ATOM   2057 C  C   B THR B 1 84  ? 11.706  15.192  -38.885 0.500 35.052  0 107 THR B C   1 ? 
ATOM   2058 O  O   A THR B 1 84  ? 12.560  15.159  -39.775 0.500 34.009  0 107 THR B O   1 ? 
ATOM   2059 O  O   B THR B 1 84  ? 12.409  15.214  -39.885 0.500 34.884  0 107 THR B O   1 ? 
ATOM   2060 C  CB  A THR B 1 84  ? 10.320  13.327  -39.741 0.500 28.983  0 107 THR B CB  1 ? 
ATOM   2061 C  CB  B THR B 1 84  ? 10.262  13.356  -39.755 0.500 36.566  0 107 THR B CB  1 ? 
ATOM   2062 O  OG1 A THR B 1 84  ? 9.305   14.282  -40.040 0.500 24.080  0 107 THR B OG1 1 ? 
ATOM   2063 O  OG1 B THR B 1 84  ? 9.861   12.024  -39.442 0.500 40.212  0 107 THR B OG1 1 ? 
ATOM   2064 N  N   . ASP B 1 85  ? 11.539  16.264  -38.098 1.000 33.101  0 108 ASP B N   1 ? 
ATOM   2065 C  CA  . ASP B 1 85  ? 12.080  17.577  -38.467 1.000 35.689  0 108 ASP B CA  1 ? 
ATOM   2066 C  C   . ASP B 1 85  ? 13.109  18.125  -37.465 1.000 32.734  0 108 ASP B C   1 ? 
ATOM   2067 O  O   . ASP B 1 85  ? 13.390  19.323  -37.484 1.000 31.841  0 108 ASP B O   1 ? 
ATOM   2068 C  CB  . ASP B 1 85  ? 10.938  18.581  -38.641 1.000 38.646  0 108 ASP B CB  1 ? 
ATOM   2069 C  CG  . ASP B 1 85  ? 10.124  18.887  -37.377 1.000 41.689  0 108 ASP B CG  1 ? 
ATOM   2070 O  OD1 . ASP B 1 85  ? 10.411  18.298  -36.293 1.000 39.860  0 108 ASP B OD1 1 ? 
ATOM   2071 O  OD2 . ASP B 1 85  ? 9.203   19.735  -37.475 1.000 44.973  0 108 ASP B OD2 1 ? 
ATOM   2072 N  N   . GLY B 1 86  ? 13.616  17.278  -36.561 1.000 30.033  0 109 GLY B N   1 ? 
ATOM   2073 C  CA  . GLY B 1 86  ? 14.694  17.621  -35.648 1.000 30.044  0 109 GLY B CA  1 ? 
ATOM   2074 C  C   . GLY B 1 86  ? 14.268  18.591  -34.542 1.000 26.243  0 109 GLY B C   1 ? 
ATOM   2075 O  O   . GLY B 1 86  ? 15.087  19.410  -34.091 1.000 27.284  0 109 GLY B O   1 ? 
ATOM   2076 N  N   . THR B 1 87  ? 12.995  18.496  -34.145 1.000 27.545  0 110 THR B N   1 ? 
ATOM   2077 C  CA  . THR B 1 87  ? 12.423  19.327  -33.088 1.000 26.978  0 110 THR B CA  1 ? 
ATOM   2078 C  C   . THR B 1 87  ? 11.636  18.505  -32.062 1.000 24.098  0 110 THR B C   1 ? 
ATOM   2079 O  O   . THR B 1 87  ? 11.290  17.359  -32.284 1.000 25.059  0 110 THR B O   1 ? 
ATOM   2080 C  CB  . THR B 1 87  ? 11.508  20.410  -33.664 1.000 27.929  0 110 THR B CB  1 ? 
ATOM   2081 O  OG1 . THR B 1 87  ? 10.346  19.779  -34.228 1.000 32.738  0 110 THR B OG1 1 ? 
ATOM   2082 C  CG2 . THR B 1 87  ? 12.226  21.312  -34.651 1.000 31.563  0 110 THR B CG2 1 ? 
ATOM   2083 N  N   . ALA B 1 88  ? 11.323  19.146  -30.927 1.000 24.579  0 111 ALA B N   1 ? 
ATOM   2084 C  CA  . ALA B 1 88  ? 10.179  18.772  -30.107 1.000 22.758  0 111 ALA B CA  1 ? 
ATOM   2085 C  C   . ALA B 1 88  ? 9.367   20.045  -29.909 1.000 24.854  0 111 ALA B C   1 ? 
ATOM   2086 O  O   . ALA B 1 88  ? 9.928   21.148  -29.886 1.000 26.822  0 111 ALA B O   1 ? 
ATOM   2087 C  CB  . ALA B 1 88  ? 10.622  18.159  -28.811 1.000 23.547  0 111 ALA B CB  1 ? 
ATOM   2088 N  N   . THR B 1 89  ? 8.059   19.887  -29.754 1.000 24.240  0 112 THR B N   1 ? 
ATOM   2089 C  CA  . THR B 1 89  ? 7.170   21.036  -29.652 1.000 23.587  0 112 THR B CA  1 ? 
ATOM   2090 C  C   . THR B 1 89  ? 6.513   21.026  -28.274 1.000 23.980  0 112 THR B C   1 ? 
ATOM   2091 O  O   . THR B 1 89  ? 5.972   20.002  -27.890 1.000 25.571  0 112 THR B O   1 ? 
ATOM   2092 C  CB  . THR B 1 89  ? 6.122   21.024  -30.766 1.000 29.315  0 112 THR B CB  1 ? 
ATOM   2093 O  OG1 . THR B 1 89  ? 6.850   20.973  -31.996 1.000 30.411  0 112 THR B OG1 1 ? 
ATOM   2094 C  CG2 . THR B 1 89  ? 5.238   22.249  -30.785 1.000 29.819  0 112 THR B CG2 1 ? 
ATOM   2095 N  N   . PHE B 1 90  ? 6.460   22.200  -27.634 1.000 23.396  0 113 PHE B N   1 ? 
ATOM   2096 C  CA  . PHE B 1 90  ? 5.775   22.351  -26.353 1.000 22.181  0 113 PHE B CA  1 ? 
ATOM   2097 C  C   . PHE B 1 90  ? 4.276   22.572  -26.583 1.000 26.605  0 113 PHE B C   1 ? 
ATOM   2098 O  O   . PHE B 1 90  ? 3.793   22.887  -27.686 1.000 27.619  0 113 PHE B O   1 ? 
ATOM   2099 C  CB  . PHE B 1 90  ? 6.402   23.498  -25.566 1.000 21.938  0 113 PHE B CB  1 ? 
ATOM   2100 C  CG  . PHE B 1 90  ? 6.454   23.361  -24.063 1.000 21.461  0 113 PHE B CG  1 ? 
ATOM   2101 C  CD1 . PHE B 1 90  ? 6.904   22.195  -23.469 1.000 21.715  0 113 PHE B CD1 1 ? 
ATOM   2102 C  CD2 . PHE B 1 90  ? 6.128   24.426  -23.240 1.000 23.941  0 113 PHE B CD2 1 ? 
ATOM   2103 C  CE1 . PHE B 1 90  ? 7.044   22.103  -22.102 1.000 22.094  0 113 PHE B CE1 1 ? 
ATOM   2104 C  CE2 . PHE B 1 90  ? 6.216   24.313  -21.854 1.000 24.395  0 113 PHE B CE2 1 ? 
ATOM   2105 C  CZ  . PHE B 1 90  ? 6.679   23.152  -21.288 1.000 21.703  0 113 PHE B CZ  1 ? 
ATOM   2106 N  N   . SER B 1 91  ? 3.510   22.443  -25.510 1.000 26.050  0 114 SER B N   1 ? 
ATOM   2107 C  CA  . SER B 1 91  ? 2.063   22.583  -25.607 1.000 26.281  0 114 SER B CA  1 ? 
ATOM   2108 C  C   . SER B 1 91  ? 1.659   24.050  -25.667 1.000 27.098  0 114 SER B C   1 ? 
ATOM   2109 O  O   . SER B 1 91  ? 0.515   24.344  -25.962 1.000 27.535  0 114 SER B O   1 ? 
ATOM   2110 C  CB  . SER B 1 91  ? 1.395   21.864  -24.452 1.000 25.985  0 114 SER B CB  1 ? 
ATOM   2111 O  OG  . SER B 1 91  ? 1.773   22.483  -23.233 1.000 25.012  0 114 SER B OG  1 ? 
ATOM   2112 N  N   . ARG B 1 92  ? 2.585   24.963  -25.349 1.000 26.716  0 115 ARG B N   1 ? 
ATOM   2113 C  CA  . ARG B 1 92  ? 2.324   26.392  -25.294 1.000 27.998  0 115 ARG B CA  1 ? 
ATOM   2114 C  C   . ARG B 1 92  ? 3.673   27.090  -25.304 1.000 26.636  0 115 ARG B C   1 ? 
ATOM   2115 O  O   . ARG B 1 92  ? 4.680   26.413  -25.462 1.000 27.445  0 115 ARG B O   1 ? 
ATOM   2116 C  CB  . ARG B 1 92  ? 1.522   26.739  -24.039 1.000 29.854  0 115 ARG B CB  1 ? 
ATOM   2117 C  CG  . ARG B 1 92  ? 2.180   26.230  -22.766 1.000 31.185  0 115 ARG B CG  1 ? 
ATOM   2118 C  CD  . ARG B 1 92  ? 1.539   26.800  -21.516 1.000 34.113  0 115 ARG B CD  1 ? 
ATOM   2119 N  NE  . ARG B 1 92  ? 0.149   26.429  -21.390 1.000 39.917  0 115 ARG B NE  1 ? 
ATOM   2120 C  CZ  . ARG B 1 92  ? -0.706  27.072  -20.602 1.000 44.954  0 115 ARG B CZ  1 ? 
ATOM   2121 N  NH1 . ARG B 1 92  ? -0.283  28.063  -19.841 1.000 46.013  0 115 ARG B NH1 1 ? 
ATOM   2122 N  NH2 . ARG B 1 92  ? -1.976  26.719  -20.576 1.000 49.585  0 115 ARG B NH2 1 ? 
ATOM   2123 N  N   . GLY B 1 93  ? 3.702   28.411  -25.161 1.000 24.572  0 116 GLY B N   1 ? 
ATOM   2124 C  CA  . GLY B 1 93  ? 4.928   29.152  -24.994 1.000 24.793  0 116 GLY B CA  1 ? 
ATOM   2125 C  C   . GLY B 1 93  ? 5.519   28.917  -23.599 1.000 27.761  0 116 GLY B C   1 ? 
ATOM   2126 O  O   . GLY B 1 93  ? 4.833   28.417  -22.706 1.000 29.677  0 116 GLY B O   1 ? 
ATOM   2127 N  N   . ILE B 1 94  ? 6.795   29.259  -23.430 1.000 27.454  0 117 ILE B N   1 ? 
ATOM   2128 C  CA  . ILE B 1 94  ? 7.465   29.136  -22.139 1.000 28.872  0 117 ILE B CA  1 ? 
ATOM   2129 C  C   . ILE B 1 94  ? 7.492   30.507  -21.476 1.000 27.803  0 117 ILE B C   1 ? 
ATOM   2130 O  O   . ILE B 1 94  ? 8.063   31.443  -22.018 1.000 28.191  0 117 ILE B O   1 ? 
ATOM   2131 C  CB  . ILE B 1 94  ? 8.877   28.536  -22.293 1.000 27.915  0 117 ILE B CB  1 ? 
ATOM   2132 C  CG1 . ILE B 1 94  ? 8.835   27.137  -22.913 1.000 29.755  0 117 ILE B CG1 1 ? 
ATOM   2133 C  CG2 . ILE B 1 94  ? 9.588   28.521  -20.945 1.000 26.329  0 117 ILE B CG2 1 ? 
ATOM   2134 C  CD1 . ILE B 1 94  ? 10.179  26.683  -23.408 1.000 34.741  0 117 ILE B CD1 1 ? 
ATOM   2135 N  N   . VAL B 1 95  ? 6.858   30.616  -20.306 1.000 26.749  0 118 VAL B N   1 ? 
ATOM   2136 C  CA  . VAL B 1 95  ? 6.665   31.913  -19.696 1.000 25.975  0 118 VAL B CA  1 ? 
ATOM   2137 C  C   . VAL B 1 95  ? 7.273   31.949  -18.294 1.000 28.339  0 118 VAL B C   1 ? 
ATOM   2138 O  O   . VAL B 1 95  ? 7.011   32.911  -17.562 1.000 28.115  0 118 VAL B O   1 ? 
ATOM   2139 C  CB  . VAL B 1 95  ? 5.178   32.287  -19.624 1.000 29.458  0 118 VAL B CB  1 ? 
ATOM   2140 C  CG1 . VAL B 1 95  ? 4.501   32.102  -20.978 1.000 37.558  0 118 VAL B CG1 1 ? 
ATOM   2141 C  CG2 . VAL B 1 95  ? 4.443   31.496  -18.540 1.000 33.824  0 118 VAL B CG2 1 ? 
ATOM   2142 N  N   . HIS B 1 96  ? 8.079   30.944  -17.919 1.000 23.727  0 119 HIS B N   1 ? 
ATOM   2143 C  CA  . HIS B 1 96  ? 8.858   31.061  -16.694 1.000 21.823  0 119 HIS B CA  1 ? 
ATOM   2144 C  C   . HIS B 1 96  ? 10.345  30.828  -17.004 1.000 23.668  0 119 HIS B C   1 ? 
ATOM   2145 O  O   . HIS B 1 96  ? 10.692  30.017  -17.852 1.000 23.954  0 119 HIS B O   1 ? 
ATOM   2146 C  CB  . HIS B 1 96  ? 8.467   30.048  -15.611 1.000 22.789  0 119 HIS B CB  1 ? 
ATOM   2147 C  CG  . HIS B 1 96  ? 7.021   29.879  -15.365 1.000 24.049  0 119 HIS B CG  1 ? 
ATOM   2148 N  ND1 . HIS B 1 96  ? 6.260   30.991  -15.071 1.000 28.492  0 119 HIS B ND1 1 ? 
ATOM   2149 C  CD2 . HIS B 1 96  ? 6.171   28.829  -15.370 1.000 26.000  0 119 HIS B CD2 1 ? 
ATOM   2150 C  CE1 . HIS B 1 96  ? 4.982   30.616  -14.955 1.000 27.492  0 119 HIS B CE1 1 ? 
ATOM   2151 N  NE2 . HIS B 1 96  ? 4.918   29.323  -15.084 1.000 25.021  0 119 HIS B NE2 1 ? 
ATOM   2152 N  N   . ALA B 1 97  ? 11.209  31.477  -16.224 1.000 22.716  0 120 ALA B N   1 ? 
ATOM   2153 C  CA  . ALA B 1 97  ? 12.653  31.309  -16.306 1.000 22.290  0 120 ALA B CA  1 ? 
ATOM   2154 C  C   . ALA B 1 97  ? 13.065  29.974  -15.685 1.000 22.903  0 120 ALA B C   1 ? 
ATOM   2155 O  O   . ALA B 1 97  ? 12.357  29.387  -14.855 1.000 25.067  0 120 ALA B O   1 ? 
ATOM   2156 C  CB  . ALA B 1 97  ? 13.324  32.431  -15.591 1.000 25.970  0 120 ALA B CB  1 ? 
ATOM   2157 N  N   . GLY B 1 98  ? 14.195  29.480  -16.158 1.000 22.772  0 121 GLY B N   1 ? 
ATOM   2158 C  CA  . GLY B 1 98  ? 14.856  28.345  -15.532 1.000 20.355  0 121 GLY B CA  1 ? 
ATOM   2159 C  C   . GLY B 1 98  ? 15.337  27.336  -16.556 1.000 19.604  0 121 GLY B C   1 ? 
ATOM   2160 O  O   . GLY B 1 98  ? 14.987  27.355  -17.756 1.000 22.518  0 121 GLY B O   1 ? 
ATOM   2161 N  N   . PRO B 1 99  ? 16.230  26.434  -16.108 1.000 17.168  0 122 PRO B N   1 ? 
ATOM   2162 C  CA  . PRO B 1 99  ? 16.878  25.504  -16.997 1.000 19.682  0 122 PRO B CA  1 ? 
ATOM   2163 C  C   . PRO B 1 99  ? 15.972  24.351  -17.424 1.000 20.679  0 122 PRO B C   1 ? 
ATOM   2164 O  O   . PRO B 1 99  ? 15.122  23.888  -16.640 1.000 18.545  0 122 PRO B O   1 ? 
ATOM   2165 C  CB  . PRO B 1 99  ? 18.030  25.000  -16.146 1.000 20.183  0 122 PRO B CB  1 ? 
ATOM   2166 C  CG  . PRO B 1 99  ? 17.517  25.072  -14.757 1.000 20.380  0 122 PRO B CG  1 ? 
ATOM   2167 C  CD  . PRO B 1 99  ? 16.681  26.329  -14.729 1.000 21.212  0 122 PRO B CD  1 ? 
ATOM   2168 N  N   . CYS B 1 100 ? 16.178  23.880  -18.640 1.000 21.612  0 123 CYS B N   1 ? 
ATOM   2169 C  CA  . CYS B 1 100 ? 15.471  22.688  -19.070 1.000 23.779  0 123 CYS B CA  1 ? 
ATOM   2170 C  C   . CYS B 1 100 ? 16.374  21.822  -19.933 1.000 23.517  0 123 CYS B C   1 ? 
ATOM   2171 O  O   . CYS B 1 100 ? 17.420  22.255  -20.366 1.000 22.062  0 123 CYS B O   1 ? 
ATOM   2172 C  CB  . CYS B 1 100 ? 14.177  22.986  -19.799 1.000 27.334  0 123 CYS B CB  1 ? 
ATOM   2173 S  SG  . CYS B 1 100 ? 14.441  23.569  -21.491 1.000 32.325  0 123 CYS B SG  1 ? 
ATOM   2174 N  N   . GLU B 1 101 ? 15.940  20.580  -20.169 1.000 22.123  0 124 GLU B N   1 ? 
ATOM   2175 C  CA  . GLU B 1 101 ? 16.753  19.639  -20.907 1.000 21.516  0 124 GLU B CA  1 ? 
ATOM   2176 C  C   . GLU B 1 101 ? 15.884  18.471  -21.372 1.000 19.916  0 124 GLU B C   1 ? 
ATOM   2177 O  O   . GLU B 1 101 ? 14.838  18.210  -20.802 1.000 18.582  0 124 GLU B O   1 ? 
ATOM   2178 C  CB  . GLU B 1 101 ? 17.941  19.153  -20.075 1.000 23.825  0 124 GLU B CB  1 ? 
ATOM   2179 C  CG  . GLU B 1 101 ? 17.570  18.653  -18.739 1.000 27.143  0 124 GLU B CG  1 ? 
ATOM   2180 C  CD  . GLU B 1 101 ? 18.756  18.573  -17.789 1.000 28.773  0 124 GLU B CD  1 ? 
ATOM   2181 O  OE1 . GLU B 1 101 ? 19.443  19.630  -17.485 1.000 32.632  0 124 GLU B OE1 1 ? 
ATOM   2182 O  OE2 . GLU B 1 101 ? 18.992  17.441  -17.337 1.000 25.485  0 124 GLU B OE2 1 ? 
ATOM   2183 N  N   . ILE B 1 102 ? 16.326  17.858  -22.463 1.000 18.960  0 125 ILE B N   1 ? 
ATOM   2184 C  CA  . ILE B 1 102 ? 15.677  16.693  -23.040 1.000 20.890  0 125 ILE B CA  1 ? 
ATOM   2185 C  C   . ILE B 1 102 ? 16.736  15.611  -23.083 1.000 21.341  0 125 ILE B C   1 ? 
ATOM   2186 O  O   . ILE B 1 102 ? 17.849  15.830  -23.583 1.000 23.830  0 125 ILE B O   1 ? 
ATOM   2187 C  CB  . ILE B 1 102 ? 15.093  16.986  -24.428 1.000 21.060  0 125 ILE B CB  1 ? 
ATOM   2188 C  CG1 . ILE B 1 102 ? 14.054  18.104  -24.388 1.000 21.816  0 125 ILE B CG1 1 ? 
ATOM   2189 C  CG2 . ILE B 1 102 ? 14.534  15.717  -25.063 1.000 22.355  0 125 ILE B CG2 1 ? 
ATOM   2190 C  CD1 . ILE B 1 102 ? 13.571  18.544  -25.728 1.000 24.905  0 125 ILE B CD1 1 ? 
ATOM   2191 N  N   . TRP B 1 103 ? 16.328  14.428  -22.639 1.000 20.417  0 126 TRP B N   1 ? 
ATOM   2192 C  CA  . TRP B 1 103 ? 17.143  13.241  -22.685 1.000 20.624  0 126 TRP B CA  1 ? 
ATOM   2193 C  C   . TRP B 1 103 ? 16.472  12.159  -23.525 1.000 19.839  0 126 TRP B C   1 ? 
ATOM   2194 O  O   . TRP B 1 103 ? 15.249  12.039  -23.511 1.000 21.631  0 126 TRP B O   1 ? 
ATOM   2195 C  CB  . TRP B 1 103 ? 17.385  12.695  -21.274 1.000 21.772  0 126 TRP B CB  1 ? 
ATOM   2196 C  CG  . TRP B 1 103 ? 18.155  13.605  -20.373 1.000 21.773  0 126 TRP B CG  1 ? 
ATOM   2197 C  CD1 . TRP B 1 103 ? 17.718  14.768  -19.793 1.000 21.966  0 126 TRP B CD1 1 ? 
ATOM   2198 C  CD2 . TRP B 1 103 ? 19.505  13.411  -19.908 1.000 24.783  0 126 TRP B CD2 1 ? 
ATOM   2199 N  NE1 . TRP B 1 103 ? 18.711  15.301  -19.009 1.000 22.861  0 126 TRP B NE1 1 ? 
ATOM   2200 C  CE2 . TRP B 1 103 ? 19.811  14.499  -19.059 1.000 21.917  0 126 TRP B CE2 1 ? 
ATOM   2201 C  CE3 . TRP B 1 103 ? 20.474  12.428  -20.124 1.000 25.951  0 126 TRP B CE3 1 ? 
ATOM   2202 C  CZ2 . TRP B 1 103 ? 21.031  14.616  -18.408 1.000 24.310  0 126 TRP B CZ2 1 ? 
ATOM   2203 C  CZ3 . TRP B 1 103 ? 21.670  12.543  -19.479 1.000 26.071  0 126 TRP B CZ3 1 ? 
ATOM   2204 C  CH2 . TRP B 1 103 ? 21.942  13.614  -18.627 1.000 26.537  0 126 TRP B CH2 1 ? 
ATOM   2205 N  N   . LEU B 1 104 ? 17.306  11.393  -24.266 1.000 21.070  0 127 LEU B N   1 ? 
ATOM   2206 C  CA  . LEU B 1 104 ? 16.897  10.151  -24.903 1.000 22.239  0 127 LEU B CA  1 ? 
ATOM   2207 C  C   . LEU B 1 104 ? 17.704  9.013   -24.284 1.000 24.240  0 127 LEU B C   1 ? 
ATOM   2208 O  O   . LEU B 1 104 ? 18.926  8.973   -24.409 1.000 24.257  0 127 LEU B O   1 ? 
ATOM   2209 C  CB  . LEU B 1 104 ? 17.134  10.234  -26.417 1.000 24.265  0 127 LEU B CB  1 ? 
ATOM   2210 C  CG  . LEU B 1 104 ? 16.385  11.330  -27.154 1.000 29.400  0 127 LEU B CG  1 ? 
ATOM   2211 C  CD1 . LEU B 1 104 ? 16.777  11.377  -28.623 1.000 31.304  0 127 LEU B CD1 1 ? 
ATOM   2212 C  CD2 . LEU B 1 104 ? 14.894  11.133  -27.034 1.000 31.516  0 127 LEU B CD2 1 ? 
ATOM   2213 N  N   . ASP B 1 105 ? 17.022  8.176   -23.508 1.000 25.835  0 128 ASP B N   1 ? 
ATOM   2214 C  CA  . ASP B 1 105 ? 17.669  7.285   -22.555 1.000 28.833  0 128 ASP B CA  1 ? 
ATOM   2215 C  C   . ASP B 1 105 ? 18.703  8.074   -21.746 1.000 28.811  0 128 ASP B C   1 ? 
ATOM   2216 O  O   . ASP B 1 105 ? 18.358  9.094   -21.144 1.000 26.115  0 128 ASP B O   1 ? 
ATOM   2217 C  CB  . ASP B 1 105 ? 18.169  6.019   -23.256 1.000 31.359  0 128 ASP B CB  1 ? 
ATOM   2218 C  CG  . ASP B 1 105 ? 17.068  5.088   -23.736 1.000 40.734  0 128 ASP B CG  1 ? 
ATOM   2219 O  OD1 . ASP B 1 105 ? 15.881  5.203   -23.262 1.000 36.189  0 128 ASP B OD1 1 ? 
ATOM   2220 O  OD2 . ASP B 1 105 ? 17.385  4.270   -24.611 1.000 42.629  0 128 ASP B OD2 1 ? 
ATOM   2221 N  N   . ASP B 1 106 ? 19.967  7.619   -21.726 1.000 25.889  0 129 ASP B N   1 ? 
ATOM   2222 C  CA  . ASP B 1 106 ? 21.007  8.237   -20.933 1.000 27.328  0 129 ASP B CA  1 ? 
ATOM   2223 C  C   . ASP B 1 106 ? 21.791  9.300   -21.713 1.000 25.444  0 129 ASP B C   1 ? 
ATOM   2224 O  O   . ASP B 1 106 ? 22.830  9.733   -21.252 1.000 27.475  0 129 ASP B O   1 ? 
ATOM   2225 C  CB  . ASP B 1 106 ? 21.959  7.166   -20.404 1.000 33.464  0 129 ASP B CB  1 ? 
ATOM   2226 C  CG  . ASP B 1 106 ? 22.707  6.429   -21.511 1.000 46.472  0 129 ASP B CG  1 ? 
ATOM   2227 O  OD1 . ASP B 1 106 ? 22.206  6.438   -22.705 1.000 44.976  0 129 ASP B OD1 1 ? 
ATOM   2228 O  OD2 . ASP B 1 106 ? 23.796  5.847   -21.197 1.000 49.091  0 129 ASP B OD2 1 ? 
ATOM   2229 N  N   . LYS B 1 107 ? 21.307  9.763   -22.854 1.000 25.857  0 130 LYS B N   1 ? 
ATOM   2230 C  CA  . LYS B 1 107 ? 21.990  10.778  -23.634 1.000 25.914  0 130 LYS B CA  1 ? 
ATOM   2231 C  C   . LYS B 1 107 ? 21.241  12.113  -23.559 1.000 24.351  0 130 LYS B C   1 ? 
ATOM   2232 O  O   . LYS B 1 107 ? 20.094  12.184  -23.953 1.000 22.503  0 130 LYS B O   1 ? 
ATOM   2233 C  CB  . LYS B 1 107 ? 22.101  10.337  -25.096 1.000 31.723  0 130 LYS B CB  1 ? 
ATOM   2234 C  CG  . LYS B 1 107 ? 22.977  11.254  -25.921 1.000 38.520  0 130 LYS B CG  1 ? 
ATOM   2235 C  CD  . LYS B 1 107 ? 23.120  10.831  -27.378 1.000 47.867  0 130 LYS B CD  1 ? 
ATOM   2236 C  CE  . LYS B 1 107 ? 23.972  11.817  -28.155 1.000 58.036  0 130 LYS B CE  1 ? 
ATOM   2237 N  NZ  . LYS B 1 107 ? 24.123  11.405  -29.576 1.000 66.517  0 130 LYS B NZ  1 ? 
ATOM   2238 N  N   . MET B 1 108 ? 21.906  13.170  -23.101 1.000 23.731  0 131 MET B N   1 ? 
ATOM   2239 C  CA  . MET B 1 108 ? 21.248  14.464  -23.091 1.000 22.719  0 131 MET B CA  1 ? 
ATOM   2240 C  C   . MET B 1 108 ? 21.371  15.057  -24.490 1.000 26.701  0 131 MET B C   1 ? 
ATOM   2241 O  O   . MET B 1 108 ? 22.494  15.265  -24.974 1.000 28.297  0 131 MET B O   1 ? 
ATOM   2242 C  CB  . MET B 1 108 ? 21.874  15.379  -22.033 1.000 26.702  0 131 MET B CB  1 ? 
ATOM   2243 C  CG  . MET B 1 108 ? 21.158  16.722  -21.863 1.000 29.028  0 131 MET B CG  1 ? 
ATOM   2244 S  SD  . MET B 1 108 ? 21.908  17.661  -20.487 1.000 36.330  0 131 MET B SD  1 ? 
ATOM   2245 C  CE  . MET B 1 108 ? 23.284  18.296  -21.428 1.000 34.229  0 131 MET B CE  1 ? 
ATOM   2246 N  N   . VAL B 1 109 ? 20.229  15.341  -25.129 1.000 21.667  0 132 VAL B N   1 ? 
ATOM   2247 C  CA  . VAL B 1 109 ? 20.206  15.772  -26.512 1.000 23.470  0 132 VAL B CA  1 ? 
ATOM   2248 C  C   . VAL B 1 109 ? 19.913  17.270  -26.639 1.000 24.448  0 132 VAL B C   1 ? 
ATOM   2249 O  O   . VAL B 1 109 ? 20.128  17.837  -27.689 1.000 24.434  0 132 VAL B O   1 ? 
ATOM   2250 C  CB  . VAL B 1 109 ? 19.258  14.937  -27.374 1.000 22.710  0 132 VAL B CB  1 ? 
ATOM   2251 C  CG1 . VAL B 1 109 ? 19.714  13.478  -27.451 1.000 22.519  0 132 VAL B CG1 1 ? 
ATOM   2252 C  CG2 . VAL B 1 109 ? 17.815  15.053  -26.921 1.000 24.790  0 132 VAL B CG2 1 ? 
ATOM   2253 N  N   . LEU B 1 110 ? 19.375  17.896  -25.586 1.000 22.519  0 133 LEU B N   1 ? 
ATOM   2254 C  CA  . LEU B 1 110 ? 19.153  19.334  -25.600 1.000 22.842  0 133 LEU B CA  1 ? 
ATOM   2255 C  C   . LEU B 1 110 ? 19.270  19.834  -24.171 1.000 21.405  0 133 LEU B C   1 ? 
ATOM   2256 O  O   . LEU B 1 110 ? 18.830  19.178  -23.249 1.000 21.654  0 133 LEU B O   1 ? 
ATOM   2257 C  CB  . LEU B 1 110 ? 17.770  19.627  -26.187 1.000 22.534  0 133 LEU B CB  1 ? 
ATOM   2258 C  CG  . LEU B 1 110 ? 17.363  21.101  -26.202 1.000 24.897  0 133 LEU B CG  1 ? 
ATOM   2259 C  CD1 . LEU B 1 110 ? 16.621  21.474  -27.457 1.000 27.421  0 133 LEU B CD1 1 ? 
ATOM   2260 C  CD2 . LEU B 1 110 ? 16.522  21.477  -24.999 1.000 26.615  0 133 LEU B CD2 1 ? 
ATOM   2261 N  N   . GLN B 1 111 ? 19.843  21.023  -23.988 1.000 23.207  0 134 GLN B N   1 ? 
ATOM   2262 C  CA  . GLN B 1 111 ? 19.990  21.597  -22.668 1.000 22.692  0 134 GLN B CA  1 ? 
ATOM   2263 C  C   . GLN B 1 111 ? 20.088  23.096  -22.838 1.000 23.878  0 134 GLN B C   1 ? 
ATOM   2264 O  O   . GLN B 1 111 ? 20.719  23.557  -23.774 1.000 21.794  0 134 GLN B O   1 ? 
ATOM   2265 C  CB  . GLN B 1 111 ? 21.256  21.099  -21.988 1.000 25.126  0 134 GLN B CB  1 ? 
ATOM   2266 C  CG  . GLN B 1 111 ? 21.446  21.569  -20.550 1.000 24.565  0 134 GLN B CG  1 ? 
ATOM   2267 C  CD  . GLN B 1 111 ? 22.003  22.964  -20.320 1.000 28.223  0 134 GLN B CD  1 ? 
ATOM   2268 O  OE1 . GLN B 1 111 ? 21.699  23.654  -19.340 1.000 30.093  0 134 GLN B OE1 1 ? 
ATOM   2269 N  NE2 . GLN B 1 111 ? 22.852  23.381  -21.213 1.000 24.811  0 134 GLN B NE2 1 ? 
ATOM   2270 N  N   . ASN B 1 112 ? 19.456  23.829  -21.936 1.000 20.945  0 135 ASN B N   1 ? 
ATOM   2271 C  CA  . ASN B 1 112 ? 19.673  25.267  -21.891 1.000 22.309  0 135 ASN B CA  1 ? 
ATOM   2272 C  C   . ASN B 1 112 ? 19.469  25.759  -20.472 1.000 22.218  0 135 ASN B C   1 ? 
ATOM   2273 O  O   . ASN B 1 112 ? 18.550  25.310  -19.762 1.000 20.777  0 135 ASN B O   1 ? 
ATOM   2274 C  CB  . ASN B 1 112 ? 18.730  25.977  -22.875 1.000 25.693  0 135 ASN B CB  1 ? 
ATOM   2275 C  CG  . ASN B 1 112 ? 19.181  27.385  -23.155 1.000 27.447  0 135 ASN B CG  1 ? 
ATOM   2276 O  OD1 . ASN B 1 112 ? 18.877  28.324  -22.428 1.000 28.050  0 135 ASN B OD1 1 ? 
ATOM   2277 N  ND2 . ASN B 1 112 ? 19.887  27.554  -24.254 1.000 32.235  0 135 ASN B ND2 1 ? 
ATOM   2278 N  N   . ASP B 1 113 ? 20.246  26.784  -20.079 1.000 22.287  0 136 ASP B N   1 ? 
ATOM   2279 C  CA  . ASP B 1 113 ? 20.151  27.332  -18.743 1.000 22.868  0 136 ASP B CA  1 ? 
ATOM   2280 C  C   . ASP B 1 113 ? 18.906  28.194  -18.576 1.000 24.492  0 136 ASP B C   1 ? 
ATOM   2281 O  O   . ASP B 1 113 ? 18.461  28.403  -17.447 1.000 24.266  0 136 ASP B O   1 ? 
ATOM   2282 C  CB  . ASP B 1 113 ? 21.403  28.167  -18.437 1.000 27.043  0 136 ASP B CB  1 ? 
ATOM   2283 C  CG  . ASP B 1 113 ? 22.697  27.378  -18.278 1.000 34.560  0 136 ASP B CG  1 ? 
ATOM   2284 O  OD1 . ASP B 1 113 ? 22.663  26.100  -18.165 1.000 32.321  0 136 ASP B OD1 1 ? 
ATOM   2285 O  OD2 . ASP B 1 113 ? 23.758  28.050  -18.262 1.000 39.584  0 136 ASP B OD2 1 ? 
ATOM   2286 N  N   . ASP B 1 114 ? 18.298  28.637  -19.689 1.000 24.118  0 137 ASP B N   1 ? 
ATOM   2287 C  CA  . ASP B 1 114 ? 17.098  29.465  -19.616 1.000 27.174  0 137 ASP B CA  1 ? 
ATOM   2288 C  C   . ASP B 1 114 ? 16.194  29.203  -20.814 1.000 26.797  0 137 ASP B C   1 ? 
ATOM   2289 O  O   . ASP B 1 114 ? 16.321  29.844  -21.855 1.000 29.329  0 137 ASP B O   1 ? 
ATOM   2290 C  CB  . ASP B 1 114 ? 17.419  30.954  -19.532 1.000 28.690  0 137 ASP B CB  1 ? 
ATOM   2291 C  CG  . ASP B 1 114 ? 16.142  31.756  -19.285 1.000 38.305  0 137 ASP B CG  1 ? 
ATOM   2292 O  OD1 . ASP B 1 114 ? 15.268  31.252  -18.501 1.000 30.107  0 137 ASP B OD1 1 ? 
ATOM   2293 O  OD2 . ASP B 1 114 ? 15.988  32.839  -19.907 1.000 36.778  0 137 ASP B OD2 1 ? 
ATOM   2294 N  N   A CYS B 1 115 ? 15.325  28.204  -20.681 0.500 23.439  0 138 CYS B N   1 ? 
ATOM   2295 N  N   B CYS B 1 115 ? 15.336  28.182  -20.735 0.500 27.083  0 138 CYS B N   1 ? 
ATOM   2296 C  CA  A CYS B 1 115 ? 14.583  27.710  -21.824 0.500 23.847  0 138 CYS B CA  1 ? 
ATOM   2297 C  CA  B CYS B 1 115 ? 14.658  27.768  -21.951 0.500 30.736  0 138 CYS B CA  1 ? 
ATOM   2298 C  C   A CYS B 1 115 ? 13.631  28.786  -22.346 0.500 25.384  0 138 CYS B C   1 ? 
ATOM   2299 C  C   B CYS B 1 115 ? 13.661  28.841  -22.386 0.500 28.416  0 138 CYS B C   1 ? 
ATOM   2300 O  O   A CYS B 1 115 ? 13.356  28.830  -23.538 0.500 26.789  0 138 CYS B O   1 ? 
ATOM   2301 O  O   B CYS B 1 115 ? 13.380  28.943  -23.571 0.500 28.771  0 138 CYS B O   1 ? 
ATOM   2302 C  CB  A CYS B 1 115 ? 13.936  26.379  -21.458 0.500 24.997  0 138 CYS B CB  1 ? 
ATOM   2303 C  CB  B CYS B 1 115 ? 14.039  26.377  -21.852 0.500 39.956  0 138 CYS B CB  1 ? 
ATOM   2304 S  SG  A CYS B 1 115 ? 15.198  25.074  -21.462 0.500 24.799  0 138 CYS B SG  1 ? 
ATOM   2305 S  SG  B CYS B 1 115 ? 12.910  26.141  -20.466 0.500 55.747  0 138 CYS B SG  1 ? 
ATOM   2306 N  N   . GLN B 1 116 ? 13.158  29.657  -21.444 1.000 26.108  0 139 GLN B N   1 ? 
ATOM   2307 C  CA  . GLN B 1 116 ? 12.260  30.756  -21.801 1.000 25.249  0 139 GLN B CA  1 ? 
ATOM   2308 C  C   . GLN B 1 116 ? 12.828  31.637  -22.917 1.000 28.736  0 139 GLN B C   1 ? 
ATOM   2309 O  O   . GLN B 1 116 ? 12.100  32.045  -23.814 1.000 31.209  0 139 GLN B O   1 ? 
ATOM   2310 C  CB  . GLN B 1 116 ? 11.979  31.608  -20.562 1.000 26.726  0 139 GLN B CB  1 ? 
ATOM   2311 C  CG  . GLN B 1 116 ? 11.093  32.810  -20.829 1.000 31.929  0 139 GLN B CG  1 ? 
ATOM   2312 C  CD  . GLN B 1 116 ? 10.659  33.433  -19.518 1.000 33.884  0 139 GLN B CD  1 ? 
ATOM   2313 O  OE1 . GLN B 1 116 ? 9.477   33.441  -19.199 1.000 42.132  0 139 GLN B OE1 1 ? 
ATOM   2314 N  NE2 . GLN B 1 116 ? 11.613  33.910  -18.732 1.000 34.892  0 139 GLN B NE2 1 ? 
ATOM   2315 N  N   . SER B 1 117 ? 14.109  31.980  -22.802 1.000 27.076  0 140 SER B N   1 ? 
ATOM   2316 C  CA  . SER B 1 117 ? 14.760  32.902  -23.700 1.000 29.710  0 140 SER B CA  1 ? 
ATOM   2317 C  C   . SER B 1 117 ? 15.288  32.163  -24.928 1.000 33.931  0 140 SER B C   1 ? 
ATOM   2318 O  O   . SER B 1 117 ? 15.568  32.786  -25.928 1.000 36.903  0 140 SER B O   1 ? 
ATOM   2319 C  CB  . SER B 1 117 ? 15.836  33.671  -22.988 1.000 34.319  0 140 SER B CB  1 ? 
ATOM   2320 O  OG  . SER B 1 117 ? 16.879  32.807  -22.536 1.000 37.623  0 140 SER B OG  1 ? 
ATOM   2321 N  N   . ALA B 1 118 ? 15.422  30.836  -24.882 1.000 28.092  0 141 ALA B N   1 ? 
ATOM   2322 C  CA  . ALA B 1 118 ? 16.009  30.123  -26.002 1.000 27.003  0 141 ALA B CA  1 ? 
ATOM   2323 C  C   . ALA B 1 118 ? 14.970  29.661  -27.022 1.000 27.803  0 141 ALA B C   1 ? 
ATOM   2324 O  O   . ALA B 1 118 ? 15.295  29.568  -28.193 1.000 28.660  0 141 ALA B O   1 ? 
ATOM   2325 C  CB  . ALA B 1 118 ? 16.828  28.954  -25.524 1.000 25.520  0 141 ALA B CB  1 ? 
ATOM   2326 N  N   . TYR B 1 119 ? 13.777  29.241  -26.582 1.000 26.600  0 142 TYR B N   1 ? 
ATOM   2327 C  CA  . TYR B 1 119 ? 12.873  28.463  -27.418 1.000 27.712  0 142 TYR B CA  1 ? 
ATOM   2328 C  C   . TYR B 1 119 ? 11.499  29.102  -27.624 1.000 32.662  0 142 TYR B C   1 ? 
ATOM   2329 O  O   . TYR B 1 119 ? 10.694  28.593  -28.410 1.000 40.876  0 142 TYR B O   1 ? 
ATOM   2330 C  CB  . TYR B 1 119 ? 12.639  27.054  -26.878 1.000 26.461  0 142 TYR B CB  1 ? 
ATOM   2331 C  CG  . TYR B 1 119 ? 13.963  26.350  -26.706 1.000 26.295  0 142 TYR B CG  1 ? 
ATOM   2332 C  CD1 . TYR B 1 119 ? 14.807  26.125  -27.787 1.000 27.999  0 142 TYR B CD1 1 ? 
ATOM   2333 C  CD2 . TYR B 1 119 ? 14.386  25.965  -25.445 1.000 28.489  0 142 TYR B CD2 1 ? 
ATOM   2334 C  CE1 . TYR B 1 119 ? 16.010  25.476  -27.618 1.000 25.082  0 142 TYR B CE1 1 ? 
ATOM   2335 C  CE2 . TYR B 1 119 ? 15.615  25.376  -25.255 1.000 29.094  0 142 TYR B CE2 1 ? 
ATOM   2336 C  CZ  . TYR B 1 119 ? 16.430  25.141  -26.348 1.000 26.722  0 142 TYR B CZ  1 ? 
ATOM   2337 O  OH  . TYR B 1 119 ? 17.606  24.553  -26.089 1.000 28.360  0 142 TYR B OH  1 ? 
ATOM   2338 N  N   . GLY B 1 120 ? 11.184  30.169  -26.911 1.000 34.347  0 143 GLY B N   1 ? 
ATOM   2339 C  CA  . GLY B 1 120 ? 10.030  30.934  -27.325 1.000 38.603  0 143 GLY B CA  1 ? 
ATOM   2340 C  C   . GLY B 1 120 ? 10.322  32.414  -27.202 1.000 38.956  0 143 GLY B C   1 ? 
ATOM   2341 O  O   . GLY B 1 120 ? 11.481  32.809  -27.111 1.000 43.400  0 143 GLY B O   1 ? 
ATOM   2342 N  N   . ASP B 1 121 ? 9.241   33.192  -27.139 1.000 40.001  0 144 ASP B N   1 ? 
ATOM   2343 C  CA  . ASP B 1 121 ? 9.345   34.635  -27.111 1.000 41.153  0 144 ASP B CA  1 ? 
ATOM   2344 C  C   . ASP B 1 121 ? 8.793   35.116  -25.784 1.000 43.623  0 144 ASP B C   1 ? 
ATOM   2345 O  O   . ASP B 1 121 ? 8.535   36.305  -25.633 1.000 45.801  0 144 ASP B O   1 ? 
ATOM   2346 C  CB  . ASP B 1 121 ? 8.633   35.262  -28.313 1.000 45.243  0 144 ASP B CB  1 ? 
ATOM   2347 C  CG  . ASP B 1 121 ? 7.119   35.101  -28.335 1.000 45.972  0 144 ASP B CG  1 ? 
ATOM   2348 O  OD1 . ASP B 1 121 ? 6.542   34.629  -27.325 1.000 41.767  0 144 ASP B OD1 1 ? 
ATOM   2349 O  OD2 . ASP B 1 121 ? 6.521   35.427  -29.375 1.000 48.036  0 144 ASP B OD2 1 ? 
ATOM   2350 N  N   . GLY B 1 122 ? 8.587   34.185  -24.841 1.000 37.897  0 145 GLY B N   1 ? 
ATOM   2351 C  CA  . GLY B 1 122 ? 8.241   34.558  -23.471 1.000 40.968  0 145 GLY B CA  1 ? 
ATOM   2352 C  C   . GLY B 1 122 ? 6.738   34.762  -23.256 1.000 38.952  0 145 GLY B C   1 ? 
ATOM   2353 O  O   . GLY B 1 122 ? 6.283   34.938  -22.124 1.000 37.797  0 145 GLY B O   1 ? 
ATOM   2354 N  N   . THR B 1 123 ? 5.974   34.713  -24.347 1.000 33.604  0 146 THR B N   1 ? 
ATOM   2355 C  CA  . THR B 1 123 ? 4.532   34.754  -24.286 1.000 34.840  0 146 THR B CA  1 ? 
ATOM   2356 C  C   . THR B 1 123 ? 3.961   33.347  -24.339 1.000 32.965  0 146 THR B C   1 ? 
ATOM   2357 O  O   . THR B 1 123 ? 4.506   32.438  -24.943 1.000 36.970  0 146 THR B O   1 ? 
ATOM   2358 C  CB  . THR B 1 123 ? 3.942   35.613  -25.412 1.000 40.167  0 146 THR B CB  1 ? 
ATOM   2359 O  OG1 . THR B 1 123 ? 3.937   34.825  -26.607 1.000 36.347  0 146 THR B OG1 1 ? 
ATOM   2360 C  CG2 . THR B 1 123 ? 4.664   36.940  -25.560 1.000 41.657  0 146 THR B CG2 1 ? 
ATOM   2361 N  N   . GLN B 1 124 ? 2.780   33.226  -23.767 1.000 33.413  0 147 GLN B N   1 ? 
ATOM   2362 C  CA  . GLN B 1 124 ? 2.088   31.963  -23.711 1.000 34.986  0 147 GLN B CA  1 ? 
ATOM   2363 C  C   . GLN B 1 124 ? 1.618   31.536  -25.098 1.000 32.320  0 147 GLN B C   1 ? 
ATOM   2364 O  O   . GLN B 1 124 ? 1.559   30.341  -25.388 1.000 32.057  0 147 GLN B O   1 ? 
ATOM   2365 C  CB  . GLN B 1 124 ? 0.926   32.135  -22.742 1.000 37.163  0 147 GLN B CB  1 ? 
ATOM   2366 C  CG  . GLN B 1 124 ? 0.344   30.837  -22.249 1.000 41.855  0 147 GLN B CG  1 ? 
ATOM   2367 C  CD  . GLN B 1 124 ? -0.550  31.161  -21.076 1.000 58.937  0 147 GLN B CD  1 ? 
ATOM   2368 O  OE1 . GLN B 1 124 ? -0.101  31.646  -20.033 1.000 66.852  0 147 GLN B OE1 1 ? 
ATOM   2369 N  NE2 . GLN B 1 124 ? -1.836  30.927  -21.257 1.000 60.365  0 147 GLN B NE2 1 ? 
ATOM   2370 N  N   . GLU B 1 125 ? 1.332   32.507  -25.976 1.000 32.008  0 148 GLU B N   1 ? 
ATOM   2371 C  CA  . GLU B 1 125 ? 0.595   32.227  -27.195 1.000 37.579  0 148 GLU B CA  1 ? 
ATOM   2372 C  C   . GLU B 1 125 ? 1.541   31.701  -28.288 1.000 39.812  0 148 GLU B C   1 ? 
ATOM   2373 O  O   . GLU B 1 125 ? 1.146   30.867  -29.098 1.000 39.634  0 148 GLU B O   1 ? 
ATOM   2374 C  CB  . GLU B 1 125 ? -0.239  33.456  -27.592 1.000 45.048  0 148 GLU B CB  1 ? 
ATOM   2375 C  CG  . GLU B 1 125 ? -0.924  34.186  -26.401 1.000 51.116  0 148 GLU B CG  1 ? 
ATOM   2376 C  CD  . GLU B 1 125 ? -0.083  35.105  -25.499 1.000 53.024  0 148 GLU B CD  1 ? 
ATOM   2377 O  OE1 . GLU B 1 125 ? 0.999   35.516  -25.939 1.000 63.583  0 148 GLU B OE1 1 ? 
ATOM   2378 O  OE2 . GLU B 1 125 ? -0.492  35.424  -24.337 1.000 55.415  0 148 GLU B OE2 1 ? 
ATOM   2379 N  N   . THR B 1 126 ? 2.813   32.100  -28.286 1.000 37.844  0 149 THR B N   1 ? 
ATOM   2380 C  CA  . THR B 1 126 ? 3.778   31.580  -29.253 1.000 35.553  0 149 THR B CA  1 ? 
ATOM   2381 C  C   . THR B 1 126 ? 4.324   30.235  -28.771 1.000 32.069  0 149 THR B C   1 ? 
ATOM   2382 O  O   . THR B 1 126 ? 5.066   30.181  -27.787 1.000 32.288  0 149 THR B O   1 ? 
ATOM   2383 C  CB  . THR B 1 126 ? 4.946   32.545  -29.462 1.000 36.519  0 149 THR B CB  1 ? 
ATOM   2384 O  OG1 . THR B 1 126 ? 4.370   33.821  -29.738 1.000 39.103  0 149 THR B OG1 1 ? 
ATOM   2385 C  CG2 . THR B 1 126 ? 5.887   32.124  -30.583 1.000 41.508  0 149 THR B CG2 1 ? 
ATOM   2386 N  N   . ILE B 1 127 ? 4.027   29.184  -29.529 1.000 29.197  0 150 ILE B N   1 ? 
ATOM   2387 C  CA  . ILE B 1 127 ? 4.338   27.816  -29.143 1.000 31.200  0 150 ILE B CA  1 ? 
ATOM   2388 C  C   . ILE B 1 127 ? 5.860   27.646  -29.140 1.000 32.796  0 150 ILE B C   1 ? 
ATOM   2389 O  O   . ILE B 1 127 ? 6.526   28.035  -30.102 1.000 29.181  0 150 ILE B O   1 ? 
ATOM   2390 C  CB  . ILE B 1 127 ? 3.663   26.802  -30.093 1.000 35.394  0 150 ILE B CB  1 ? 
ATOM   2391 C  CG1 . ILE B 1 127 ? 2.133   26.929  -30.144 1.000 37.944  0 150 ILE B CG1 1 ? 
ATOM   2392 C  CG2 . ILE B 1 127 ? 4.111   25.376  -29.767 1.000 38.243  0 150 ILE B CG2 1 ? 
ATOM   2393 C  CD1 . ILE B 1 127 ? 1.443   26.903  -28.818 1.000 37.880  0 150 ILE B CD1 1 ? 
ATOM   2394 N  N   . ALA B 1 128 ? 6.409   27.096  -28.042 1.000 28.631  0 151 ALA B N   1 ? 
ATOM   2395 C  CA  . ALA B 1 128 ? 7.851   26.945  -27.949 1.000 28.539  0 151 ALA B CA  1 ? 
ATOM   2396 C  C   . ALA B 1 128 ? 8.263   25.715  -28.754 1.000 26.535  0 151 ALA B C   1 ? 
ATOM   2397 O  O   . ALA B 1 128 ? 7.665   24.656  -28.655 1.000 26.115  0 151 ALA B O   1 ? 
ATOM   2398 C  CB  . ALA B 1 128 ? 8.323   26.847  -26.513 1.000 27.541  0 151 ALA B CB  1 ? 
ATOM   2399 N  N   . VAL B 1 129 ? 9.343   25.850  -29.506 1.000 26.006  0 152 VAL B N   1 ? 
ATOM   2400 C  CA  . VAL B 1 129 ? 9.860   24.733  -30.290 1.000 27.360  0 152 VAL B CA  1 ? 
ATOM   2401 C  C   . VAL B 1 129 ? 11.278  24.470  -29.817 1.000 27.308  0 152 VAL B C   1 ? 
ATOM   2402 O  O   . VAL B 1 129 ? 12.122  25.373  -29.833 1.000 26.925  0 152 VAL B O   1 ? 
ATOM   2403 C  CB  . VAL B 1 129 ? 9.818   25.037  -31.802 1.000 30.105  0 152 VAL B CB  1 ? 
ATOM   2404 C  CG1 . VAL B 1 129 ? 10.544  23.997  -32.614 1.000 31.322  0 152 VAL B CG1 1 ? 
ATOM   2405 C  CG2 . VAL B 1 129 ? 8.392   25.118  -32.339 1.000 35.372  0 152 VAL B CG2 1 ? 
ATOM   2406 N  N   . PHE B 1 130 ? 11.518  23.240  -29.377 1.000 25.056  0 153 PHE B N   1 ? 
ATOM   2407 C  CA  . PHE B 1 130 ? 12.843  22.831  -28.947 1.000 24.963  0 153 PHE B CA  1 ? 
ATOM   2408 C  C   . PHE B 1 130 ? 13.663  22.368  -30.144 1.000 26.613  0 153 PHE B C   1 ? 
ATOM   2409 O  O   . PHE B 1 130 ? 13.232  21.483  -30.866 1.000 25.859  0 153 PHE B O   1 ? 
ATOM   2410 C  CB  . PHE B 1 130 ? 12.757  21.724  -27.906 1.000 24.332  0 153 PHE B CB  1 ? 
ATOM   2411 C  CG  . PHE B 1 130 ? 12.040  22.134  -26.641 1.000 23.164  0 153 PHE B CG  1 ? 
ATOM   2412 C  CD1 . PHE B 1 130 ? 12.668  22.885  -25.677 1.000 26.857  0 153 PHE B CD1 1 ? 
ATOM   2413 C  CD2 . PHE B 1 130 ? 10.736  21.715  -26.417 1.000 25.248  0 153 PHE B CD2 1 ? 
ATOM   2414 C  CE1 . PHE B 1 130 ? 12.006  23.249  -24.521 1.000 27.913  0 153 PHE B CE1 1 ? 
ATOM   2415 C  CE2 . PHE B 1 130 ? 10.065  22.094  -25.267 1.000 27.951  0 153 PHE B CE2 1 ? 
ATOM   2416 C  CZ  . PHE B 1 130 ? 10.711  22.863  -24.330 1.000 27.098  0 153 PHE B CZ  1 ? 
ATOM   2417 N  N   . LYS B 1 131 ? 14.844  22.971  -30.330 1.000 25.022  0 154 LYS B N   1 ? 
ATOM   2418 C  CA  . LYS B 1 131 ? 15.672  22.543  -31.453 1.000 27.227  0 154 LYS B CA  1 ? 
ATOM   2419 C  C   . LYS B 1 131 ? 17.124  22.914  -31.200 1.000 24.513  0 154 LYS B C   1 ? 
ATOM   2420 O  O   . LYS B 1 131 ? 17.385  23.908  -30.524 1.000 25.142  0 154 LYS B O   1 ? 
ATOM   2421 C  CB  . LYS B 1 131 ? 15.177  23.185  -32.757 1.000 27.540  0 154 LYS B CB  1 ? 
ATOM   2422 C  CG  . LYS B 1 131 ? 15.173  24.705  -32.709 1.000 33.478  0 154 LYS B CG  1 ? 
ATOM   2423 C  CD  . LYS B 1 131 ? 14.537  25.364  -33.910 1.000 39.897  0 154 LYS B CD  1 ? 
ATOM   2424 C  CE  . LYS B 1 131 ? 15.499  25.482  -35.058 1.000 45.417  0 154 LYS B CE  1 ? 
ATOM   2425 N  NZ  . LYS B 1 131 ? 14.982  26.432  -36.075 1.000 53.522  0 154 LYS B NZ  1 ? 
ATOM   2426 N  N   . PRO B 1 132 ? 18.120  22.185  -31.761 1.000 27.593  0 155 PRO B N   1 ? 
ATOM   2427 C  CA  . PRO B 1 132 ? 17.881  20.952  -32.502 1.000 26.613  0 155 PRO B CA  1 ? 
ATOM   2428 C  C   . PRO B 1 132 ? 17.697  19.780  -31.540 1.000 27.524  0 155 PRO B C   1 ? 
ATOM   2429 O  O   . PRO B 1 132 ? 18.344  19.737  -30.503 1.000 26.437  0 155 PRO B O   1 ? 
ATOM   2430 C  CB  . PRO B 1 132 ? 19.207  20.713  -33.247 1.000 28.544  0 155 PRO B CB  1 ? 
ATOM   2431 C  CG  . PRO B 1 132 ? 20.259  21.373  -32.383 1.000 30.305  0 155 PRO B CG  1 ? 
ATOM   2432 C  CD  . PRO B 1 132 ? 19.557  22.537  -31.701 1.000 29.853  0 155 PRO B CD  1 ? 
ATOM   2433 N  N   . VAL B 1 133 ? 16.902  18.796  -31.942 1.000 26.301  0 156 VAL B N   1 ? 
ATOM   2434 C  CA  . VAL B 1 133 ? 16.794  17.558  -31.202 1.000 25.854  0 156 VAL B CA  1 ? 
ATOM   2435 C  C   . VAL B 1 133 ? 17.128  16.450  -32.184 1.000 25.414  0 156 VAL B C   1 ? 
ATOM   2436 O  O   . VAL B 1 133 ? 16.369  16.243  -33.126 1.000 29.685  0 156 VAL B O   1 ? 
ATOM   2437 C  CB  . VAL B 1 133 ? 15.387  17.356  -30.606 1.000 25.156  0 156 VAL B CB  1 ? 
ATOM   2438 C  CG1 . VAL B 1 133 ? 15.254  16.021  -29.882 1.000 28.134  0 156 VAL B CG1 1 ? 
ATOM   2439 C  CG2 . VAL B 1 133 ? 15.049  18.501  -29.685 1.000 26.812  0 156 VAL B CG2 1 ? 
ATOM   2440 N  N   . ASP B 1 134 ? 18.221  15.741  -31.911 1.000 25.587  0 157 ASP B N   1 ? 
ATOM   2441 C  CA  . ASP B 1 134 ? 18.641  14.607  -32.718 1.000 25.368  0 157 ASP B CA  1 ? 
ATOM   2442 C  C   . ASP B 1 134 ? 18.093  13.329  -32.091 1.000 26.732  0 157 ASP B C   1 ? 
ATOM   2443 O  O   . ASP B 1 134 ? 18.500  12.967  -30.993 1.000 30.667  0 157 ASP B O   1 ? 
ATOM   2444 C  CB  . ASP B 1 134 ? 20.156  14.565  -32.773 1.000 25.772  0 157 ASP B CB  1 ? 
ATOM   2445 C  CG  . ASP B 1 134 ? 20.784  13.476  -33.627 1.000 32.143  0 157 ASP B CG  1 ? 
ATOM   2446 O  OD1 . ASP B 1 134 ? 20.033  12.725  -34.297 1.000 33.948  0 157 ASP B OD1 1 ? 
ATOM   2447 O  OD2 . ASP B 1 134 ? 22.027  13.385  -33.603 1.000 39.510  0 157 ASP B OD2 1 ? 
ATOM   2448 N  N   . TYR B 1 135 ? 17.173  12.664  -32.800 1.000 25.277  0 158 TYR B N   1 ? 
ATOM   2449 C  CA  . TYR B 1 135 ? 16.583  11.440  -32.299 1.000 25.309  0 158 TYR B CA  1 ? 
ATOM   2450 C  C   . TYR B 1 135 ? 17.335  10.213  -32.797 1.000 30.438  0 158 TYR B C   1 ? 
ATOM   2451 O  O   . TYR B 1 135 ? 16.882  9.092   -32.545 1.000 27.489  0 158 TYR B O   1 ? 
ATOM   2452 C  CB  . TYR B 1 135 ? 15.148  11.335  -32.784 1.000 25.311  0 158 TYR B CB  1 ? 
ATOM   2453 C  CG  . TYR B 1 135 ? 14.182  12.351  -32.207 1.000 22.514  0 158 TYR B CG  1 ? 
ATOM   2454 C  CD1 . TYR B 1 135 ? 13.685  12.247  -30.907 1.000 24.108  0 158 TYR B CD1 1 ? 
ATOM   2455 C  CD2 . TYR B 1 135 ? 13.869  13.505  -32.909 1.000 24.575  0 158 TYR B CD2 1 ? 
ATOM   2456 C  CE1 . TYR B 1 135 ? 12.787  13.174  -30.409 1.000 23.330  0 158 TYR B CE1 1 ? 
ATOM   2457 C  CE2 . TYR B 1 135 ? 13.000  14.458  -32.401 1.000 25.864  0 158 TYR B CE2 1 ? 
ATOM   2458 C  CZ  . TYR B 1 135 ? 12.437  14.278  -31.149 1.000 24.273  0 158 TYR B CZ  1 ? 
ATOM   2459 O  OH  . TYR B 1 135 ? 11.659  15.278  -30.671 1.000 25.615  0 158 TYR B OH  1 ? 
ATOM   2460 N  N   . SER B 1 136 ? 18.445  10.418  -33.517 1.000 28.443  0 159 SER B N   1 ? 
ATOM   2461 C  CA  . SER B 1 136 ? 19.068  9.303   -34.229 1.000 31.043  0 159 SER B CA  1 ? 
ATOM   2462 C  C   . SER B 1 136 ? 19.649  8.266   -33.277 1.000 29.950  0 159 SER B C   1 ? 
ATOM   2463 O  O   . SER B 1 136 ? 19.814  7.113   -33.666 1.000 34.104  0 159 SER B O   1 ? 
ATOM   2464 C  CB  . SER B 1 136 ? 20.096  9.802   -35.240 1.000 34.706  0 159 SER B CB  1 ? 
ATOM   2465 O  OG  . SER B 1 136 ? 21.204  10.390  -34.591 1.000 36.014  0 159 SER B OG  1 ? 
ATOM   2466 N  N   . SER B 1 137 ? 19.891  8.624   -32.008 1.000 32.872  0 160 SER B N   1 ? 
ATOM   2467 C  CA  . SER B 1 137 ? 20.426  7.686   -31.021 1.000 34.073  0 160 SER B CA  1 ? 
ATOM   2468 C  C   . SER B 1 137 ? 19.375  6.741   -30.452 1.000 37.726  0 160 SER B C   1 ? 
ATOM   2469 O  O   . SER B 1 137 ? 19.724  5.837   -29.689 1.000 37.008  0 160 SER B O   1 ? 
ATOM   2470 C  CB  . SER B 1 137 ? 21.106  8.382   -29.879 1.000 37.987  0 160 SER B CB  1 ? 
ATOM   2471 O  OG  . SER B 1 137 ? 20.167  8.993   -29.001 1.000 36.172  0 160 SER B OG  1 ? 
ATOM   2472 N  N   A CYS B 1 138 ? 18.100  6.934   -30.805 0.500 35.308  0 161 CYS B N   1 ? 
ATOM   2473 N  N   B CYS B 1 138 ? 18.097  6.973   -30.770 0.500 36.083  0 161 CYS B N   1 ? 
ATOM   2474 C  CA  A CYS B 1 138 ? 17.023  6.174   -30.189 0.500 35.821  0 161 CYS B CA  1 ? 
ATOM   2475 C  CA  B CYS B 1 138 ? 17.044  6.149   -30.205 0.500 36.915  0 161 CYS B CA  1 ? 
ATOM   2476 C  C   A CYS B 1 138 ? 17.157  4.710   -30.599 0.500 38.804  0 161 CYS B C   1 ? 
ATOM   2477 C  C   B CYS B 1 138 ? 17.313  4.710   -30.613 0.500 40.608  0 161 CYS B C   1 ? 
ATOM   2478 O  O   A CYS B 1 138 ? 17.029  4.398   -31.787 0.500 33.460  0 161 CYS B O   1 ? 
ATOM   2479 O  O   B CYS B 1 138 ? 17.484  4.423   -31.800 0.500 40.864  0 161 CYS B O   1 ? 
ATOM   2480 C  CB  A CYS B 1 138 ? 15.660  6.723   -30.589 0.500 36.405  0 161 CYS B CB  1 ? 
ATOM   2481 C  CB  B CYS B 1 138 ? 15.653  6.570   -30.651 0.500 36.645  0 161 CYS B CB  1 ? 
ATOM   2482 S  SG  A CYS B 1 138 ? 14.287  6.110   -29.580 0.500 40.649  0 161 CYS B SG  1 ? 
ATOM   2483 S  SG  B CYS B 1 138 ? 15.153  8.165   -29.957 0.500 40.072  0 161 CYS B SG  1 ? 
ATOM   2484 N  N   . ALA B 1 139 ? 17.406  3.837   -29.607 1.000 38.859  0 162 ALA B N   1 ? 
ATOM   2485 C  CA  . ALA B 1 139 ? 17.721  2.438   -29.851 1.000 44.460  0 162 ALA B CA  1 ? 
ATOM   2486 C  C   . ALA B 1 139 ? 16.603  1.822   -30.684 1.000 43.303  0 162 ALA B C   1 ? 
ATOM   2487 O  O   . ALA B 1 139 ? 15.425  2.147   -30.505 1.000 44.818  0 162 ALA B O   1 ? 
ATOM   2488 C  CB  . ALA B 1 139 ? 17.913  1.685   -28.558 1.000 44.596  0 162 ALA B CB  1 ? 
ATOM   2489 N  N   . SER B 1 140 ? 16.978  0.973   -31.646 1.000 48.050  0 163 SER B N   1 ? 
ATOM   2490 C  CA  . SER B 1 140 ? 15.966  0.219   -32.353 1.000 51.895  0 163 SER B CA  1 ? 
ATOM   2491 C  C   . SER B 1 140 ? 15.270  -0.621  -31.287 1.000 50.559  0 163 SER B C   1 ? 
ATOM   2492 O  O   . SER B 1 140 ? 15.918  -1.094  -30.357 1.000 67.420  0 163 SER B O   1 ? 
ATOM   2493 C  CB  . SER B 1 140 ? 16.584  -0.605  -33.462 1.000 55.685  0 163 SER B CB  1 ? 
ATOM   2494 O  OG  . SER B 1 140 ? 17.534  -1.509  -32.925 1.000 50.805  0 163 SER B OG  1 ? 
ATOM   2495 N  N   . GLY B 1 141 ? 13.949  -0.737  -31.349 1.000 54.575  0 164 GLY B N   1 ? 
ATOM   2496 C  CA  . GLY B 1 141 ? 13.223  -1.355  -30.249 1.000 55.314  0 164 GLY B CA  1 ? 
ATOM   2497 C  C   . GLY B 1 141 ? 12.689  -0.313  -29.264 1.000 53.174  0 164 GLY B C   1 ? 
ATOM   2498 O  O   . GLY B 1 141 ? 11.753  -0.589  -28.524 1.000 53.165  0 164 GLY B O   1 ? 
ATOM   2499 N  N   . GLY B 1 142 ? 13.323  0.862   -29.223 1.000 42.657  0 165 GLY B N   1 ? 
ATOM   2500 C  CA  . GLY B 1 142 ? 12.672  2.044   -28.674 1.000 45.313  0 165 GLY B CA  1 ? 
ATOM   2501 C  C   . GLY B 1 142 ? 13.487  2.713   -27.569 1.000 42.964  0 165 GLY B C   1 ? 
ATOM   2502 O  O   . GLY B 1 142 ? 14.435  2.127   -27.023 1.000 37.547  0 165 GLY B O   1 ? 
ATOM   2503 N  N   A CYS B 1 143 ? 13.147  3.977   -27.272 0.500 34.359  0 166 CYS B N   1 ? 
ATOM   2504 N  N   B CYS B 1 143 ? 12.989  3.890   -27.181 0.500 36.398  0 166 CYS B N   1 ? 
ATOM   2505 C  CA  A CYS B 1 143 ? 13.820  4.705   -26.209 0.500 33.296  0 166 CYS B CA  1 ? 
ATOM   2506 C  CA  B CYS B 1 143 ? 13.728  4.826   -26.365 0.500 36.721  0 166 CYS B CA  1 ? 
ATOM   2507 C  C   A CYS B 1 143 ? 12.843  5.667   -25.547 0.500 29.196  0 166 CYS B C   1 ? 
ATOM   2508 C  C   B CYS B 1 143 ? 12.737  5.483   -25.411 0.500 31.393  0 166 CYS B C   1 ? 
ATOM   2509 O  O   A CYS B 1 143 ? 11.809  6.012   -26.120 0.500 25.983  0 166 CYS B O   1 ? 
ATOM   2510 O  O   B CYS B 1 143 ? 11.528  5.320   -25.576 0.500 28.720  0 166 CYS B O   1 ? 
ATOM   2511 C  CB  A CYS B 1 143 ? 15.020  5.489   -26.732 0.500 31.749  0 166 CYS B CB  1 ? 
ATOM   2512 C  CB  B CYS B 1 143 ? 14.415  5.813   -27.302 0.500 37.529  0 166 CYS B CB  1 ? 
ATOM   2513 S  SG  A CYS B 1 143 ? 14.562  6.959   -27.684 0.500 34.160  0 166 CYS B SG  1 ? 
ATOM   2514 S  SG  B CYS B 1 143 ? 15.749  6.775   -26.553 0.500 40.585  0 166 CYS B SG  1 ? 
ATOM   2515 N  N   . MET B 1 144 ? 13.253  6.146   -24.366 1.000 29.414  0 167 MET B N   1 ? 
ATOM   2516 C  CA  . MET B 1 144 ? 12.421  6.967   -23.506 1.000 24.868  0 167 MET B CA  1 ? 
ATOM   2517 C  C   . MET B 1 144 ? 12.944  8.398   -23.614 1.000 22.449  0 167 MET B C   1 ? 
ATOM   2518 O  O   . MET B 1 144 ? 14.091  8.648   -23.260 1.000 24.588  0 167 MET B O   1 ? 
ATOM   2519 C  CB  . MET B 1 144 ? 12.532  6.496   -22.046 1.000 28.042  0 167 MET B CB  1 ? 
ATOM   2520 C  CG  . MET B 1 144 ? 11.552  7.163   -21.084 1.000 27.509  0 167 MET B CG  1 ? 
ATOM   2521 S  SD  . MET B 1 144 ? 9.797   6.843   -21.459 1.000 30.452  0 167 MET B SD  1 ? 
ATOM   2522 C  CE  . MET B 1 144 ? 9.696   5.114   -20.995 1.000 34.894  0 167 MET B CE  1 ? 
ATOM   2523 N  N   . LEU B 1 145 ? 12.120  9.308   -24.093 1.000 24.804  0 168 LEU B N   1 ? 
ATOM   2524 C  CA  . LEU B 1 145 ? 12.440  10.728  -24.003 1.000 22.383  0 168 LEU B CA  1 ? 
ATOM   2525 C  C   . LEU B 1 145 ? 12.032  11.200  -22.608 1.000 22.480  0 168 LEU B C   1 ? 
ATOM   2526 O  O   . LEU B 1 145 ? 10.933  10.901  -22.135 1.000 21.767  0 168 LEU B O   1 ? 
ATOM   2527 C  CB  . LEU B 1 145 ? 11.657  11.499  -25.071 1.000 24.242  0 168 LEU B CB  1 ? 
ATOM   2528 C  CG  . LEU B 1 145 ? 11.891  13.018  -25.103 1.000 25.065  0 168 LEU B CG  1 ? 
ATOM   2529 C  CD1 . LEU B 1 145 ? 11.642  13.597  -26.477 1.000 26.118  0 168 LEU B CD1 1 ? 
ATOM   2530 C  CD2 . LEU B 1 145 ? 11.003  13.792  -24.142 1.000 29.455  0 168 LEU B CD2 1 ? 
ATOM   2531 N  N   . ARG B 1 146 ? 12.909  11.958  -21.968 1.000 22.641  0 169 ARG B N   1 ? 
ATOM   2532 C  CA  . ARG B 1 146 ? 12.579  12.586  -20.711 1.000 20.738  0 169 ARG B CA  1 ? 
ATOM   2533 C  C   . ARG B 1 146 ? 12.850  14.078  -20.818 1.000 23.696  0 169 ARG B C   1 ? 
ATOM   2534 O  O   . ARG B 1 146 ? 13.918  14.468  -21.276 1.000 22.833  0 169 ARG B O   1 ? 
ATOM   2535 C  CB  . ARG B 1 146 ? 13.413  11.967  -19.600 1.000 22.168  0 169 ARG B CB  1 ? 
ATOM   2536 C  CG  . ARG B 1 146 ? 12.964  10.556  -19.231 1.000 21.455  0 169 ARG B CG  1 ? 
ATOM   2537 C  CD  . ARG B 1 146 ? 13.789  10.024  -18.076 1.000 23.547  0 169 ARG B CD  1 ? 
ATOM   2538 N  NE  . ARG B 1 146 ? 13.347  8.675   -17.679 1.000 25.246  0 169 ARG B NE  1 ? 
ATOM   2539 C  CZ  . ARG B 1 146 ? 13.805  7.545   -18.201 1.000 25.666  0 169 ARG B CZ  1 ? 
ATOM   2540 N  NH1 . ARG B 1 146 ? 14.675  7.552   -19.206 1.000 24.377  0 169 ARG B NH1 1 ? 
ATOM   2541 N  NH2 . ARG B 1 146 ? 13.352  6.390   -17.744 1.000 28.427  0 169 ARG B NH2 1 ? 
ATOM   2542 N  N   . PHE B 1 147 ? 11.875  14.860  -20.378 1.000 20.662  0 170 PHE B N   1 ? 
ATOM   2543 C  CA  . PHE B 1 147 ? 11.973  16.307  -20.332 1.000 19.025  0 170 PHE B CA  1 ? 
ATOM   2544 C  C   . PHE B 1 147 ? 12.012  16.678  -18.856 1.000 20.396  0 170 PHE B C   1 ? 
ATOM   2545 O  O   . PHE B 1 147 ? 11.197  16.172  -18.067 1.000 20.683  0 170 PHE B O   1 ? 
ATOM   2546 C  CB  . PHE B 1 147 ? 10.749  16.935  -20.990 1.000 19.789  0 170 PHE B CB  1 ? 
ATOM   2547 C  CG  . PHE B 1 147 ? 10.621  18.430  -20.840 1.000 19.813  0 170 PHE B CG  1 ? 
ATOM   2548 C  CD1 . PHE B 1 147 ? 11.548  19.275  -21.431 1.000 22.296  0 170 PHE B CD1 1 ? 
ATOM   2549 C  CD2 . PHE B 1 147 ? 9.591   18.994  -20.102 1.000 22.180  0 170 PHE B CD2 1 ? 
ATOM   2550 C  CE1 . PHE B 1 147 ? 11.407  20.651  -21.337 1.000 22.129  0 170 PHE B CE1 1 ? 
ATOM   2551 C  CE2 . PHE B 1 147 ? 9.446   20.365  -20.007 1.000 23.021  0 170 PHE B CE2 1 ? 
ATOM   2552 C  CZ  . PHE B 1 147 ? 10.353  21.199  -20.636 1.000 22.118  0 170 PHE B CZ  1 ? 
ATOM   2553 N  N   . TYR B 1 148 ? 12.920  17.583  -18.518 1.000 17.301  0 171 TYR B N   1 ? 
ATOM   2554 C  CA  . TYR B 1 148 ? 13.022  18.139  -17.183 1.000 19.056  0 171 TYR B CA  1 ? 
ATOM   2555 C  C   . TYR B 1 148 ? 13.118  19.660  -17.303 1.000 19.827  0 171 TYR B C   1 ? 
ATOM   2556 O  O   . TYR B 1 148 ? 13.866  20.176  -18.142 1.000 20.216  0 171 TYR B O   1 ? 
ATOM   2557 C  CB  . TYR B 1 148 ? 14.279  17.669  -16.468 1.000 18.975  0 171 TYR B CB  1 ? 
ATOM   2558 C  CG  . TYR B 1 148 ? 14.366  16.193  -16.184 1.000 21.080  0 171 TYR B CG  1 ? 
ATOM   2559 C  CD1 . TYR B 1 148 ? 14.787  15.299  -17.156 1.000 23.493  0 171 TYR B CD1 1 ? 
ATOM   2560 C  CD2 . TYR B 1 148 ? 14.018  15.688  -14.950 1.000 23.867  0 171 TYR B CD2 1 ? 
ATOM   2561 C  CE1 . TYR B 1 148 ? 14.910  13.946  -16.902 1.000 21.764  0 171 TYR B CE1 1 ? 
ATOM   2562 C  CE2 . TYR B 1 148 ? 14.139  14.334  -14.683 1.000 24.418  0 171 TYR B CE2 1 ? 
ATOM   2563 C  CZ  . TYR B 1 148 ? 14.581  13.460  -15.657 1.000 23.962  0 171 TYR B CZ  1 ? 
ATOM   2564 O  OH  . TYR B 1 148 ? 14.691  12.110  -15.420 1.000 27.773  0 171 TYR B OH  1 ? 
ATOM   2565 N  N   . TRP B 1 149 ? 12.344  20.354  -16.481 1.000 18.686  0 172 TRP B N   1 ? 
ATOM   2566 C  CA  . TRP B 1 149 ? 12.332  21.814  -16.431 1.000 18.417  0 172 TRP B CA  1 ? 
ATOM   2567 C  C   . TRP B 1 149 ? 12.157  22.260  -14.982 1.000 19.069  0 172 TRP B C   1 ? 
ATOM   2568 O  O   . TRP B 1 149 ? 11.231  21.819  -14.271 1.000 19.163  0 172 TRP B O   1 ? 
ATOM   2569 C  CB  . TRP B 1 149 ? 11.211  22.349  -17.324 1.000 17.843  0 172 TRP B CB  1 ? 
ATOM   2570 C  CG  . TRP B 1 149 ? 11.051  23.854  -17.401 1.000 19.963  0 172 TRP B CG  1 ? 
ATOM   2571 C  CD1 . TRP B 1 149 ? 11.983  24.824  -17.216 1.000 22.304  0 172 TRP B CD1 1 ? 
ATOM   2572 C  CD2 . TRP B 1 149 ? 9.815   24.556  -17.658 1.000 21.315  0 172 TRP B CD2 1 ? 
ATOM   2573 N  NE1 . TRP B 1 149 ? 11.441  26.065  -17.398 1.000 22.525  0 172 TRP B NE1 1 ? 
ATOM   2574 C  CE2 . TRP B 1 149 ? 10.103  25.933  -17.665 1.000 22.784  0 172 TRP B CE2 1 ? 
ATOM   2575 C  CE3 . TRP B 1 149 ? 8.514   24.139  -17.906 1.000 22.274  0 172 TRP B CE3 1 ? 
ATOM   2576 C  CZ2 . TRP B 1 149 ? 9.108   26.891  -17.865 1.000 23.838  0 172 TRP B CZ2 1 ? 
ATOM   2577 C  CZ3 . TRP B 1 149 ? 7.538   25.088  -18.129 1.000 25.281  0 172 TRP B CZ3 1 ? 
ATOM   2578 C  CH2 . TRP B 1 149 ? 7.836   26.440  -18.108 1.000 21.327  0 172 TRP B CH2 1 ? 
ATOM   2579 N  N   . LEU B 1 150 ? 13.097  23.101  -14.544 1.000 19.380  0 173 LEU B N   1 ? 
ATOM   2580 C  CA  . LEU B 1 150 ? 13.035  23.676  -13.220 1.000 17.876  0 173 LEU B CA  1 ? 
ATOM   2581 C  C   . LEU B 1 150 ? 12.732  25.164  -13.375 1.000 20.991  0 173 LEU B C   1 ? 
ATOM   2582 O  O   . LEU B 1 150 ? 13.589  25.934  -13.786 1.000 21.586  0 173 LEU B O   1 ? 
ATOM   2583 C  CB  . LEU B 1 150 ? 14.353  23.394  -12.507 1.000 20.562  0 173 LEU B CB  1 ? 
ATOM   2584 C  CG  . LEU B 1 150 ? 14.403  23.902  -11.062 1.000 24.981  0 173 LEU B CG  1 ? 
ATOM   2585 C  CD1 . LEU B 1 150 ? 13.473  23.087  -10.177 1.000 29.938  0 173 LEU B CD1 1 ? 
ATOM   2586 C  CD2 . LEU B 1 150 ? 15.810  23.870  -10.524 1.000 30.592  0 173 LEU B CD2 1 ? 
ATOM   2587 N  N   . ALA B 1 151 ? 11.469  25.519  -13.166 1.000 20.845  0 174 ALA B N   1 ? 
ATOM   2588 C  CA  . ALA B 1 151 ? 10.992  26.886  -13.338 1.000 20.814  0 174 ALA B CA  1 ? 
ATOM   2589 C  C   . ALA B 1 151 ? 11.260  27.652  -12.044 1.000 22.650  0 174 ALA B C   1 ? 
ATOM   2590 O  O   . ALA B 1 151 ? 11.056  27.146  -10.937 1.000 22.844  0 174 ALA B O   1 ? 
ATOM   2591 C  CB  . ALA B 1 151 ? 9.520   26.876  -13.693 1.000 23.453  0 174 ALA B CB  1 ? 
ATOM   2592 N  N   . LEU B 1 152 ? 11.796  28.861  -12.192 1.000 21.324  0 175 LEU B N   1 ? 
ATOM   2593 C  CA  . LEU B 1 152 ? 12.091  29.732  -11.089 1.000 21.830  0 175 LEU B CA  1 ? 
ATOM   2594 C  C   . LEU B 1 152 ? 11.150  30.931  -11.198 1.000 23.007  0 175 LEU B C   1 ? 
ATOM   2595 O  O   . LEU B 1 152 ? 11.122  31.563  -12.252 1.000 25.801  0 175 LEU B O   1 ? 
ATOM   2596 C  CB  . LEU B 1 152 ? 13.524  30.258  -11.213 1.000 23.089  0 175 LEU B CB  1 ? 
ATOM   2597 C  CG  . LEU B 1 152 ? 14.581  29.186  -11.462 1.000 24.788  0 175 LEU B CG  1 ? 
ATOM   2598 C  CD1 . LEU B 1 152 ? 15.892  29.844  -11.906 1.000 22.630  0 175 LEU B CD1 1 ? 
ATOM   2599 C  CD2 . LEU B 1 152 ? 14.746  28.355  -10.193 1.000 26.472  0 175 LEU B CD2 1 ? 
ATOM   2600 N  N   . GLN B 1 153 ? 10.425  31.204  -10.122 1.000 23.339  0 176 GLN B N   1 ? 
ATOM   2601 C  CA  . GLN B 1 153 ? 9.477   32.329  -10.131 1.000 25.691  0 176 GLN B CA  1 ? 
ATOM   2602 C  C   . GLN B 1 153 ? 9.403   33.002  -8.780  1.000 23.617  0 176 GLN B C   1 ? 
ATOM   2603 O  O   . GLN B 1 153 ? 9.449   32.321  -7.773  1.000 23.833  0 176 GLN B O   1 ? 
ATOM   2604 C  CB  . GLN B 1 153 ? 8.041   31.867  -10.346 1.000 31.420  0 176 GLN B CB  1 ? 
ATOM   2605 C  CG  . GLN B 1 153 ? 7.801   31.182  -11.651 1.000 33.287  0 176 GLN B CG  1 ? 
ATOM   2606 C  CD  . GLN B 1 153 ? 6.371   30.730  -11.772 1.000 31.754  0 176 GLN B CD  1 ? 
ATOM   2607 O  OE1 . GLN B 1 153 ? 6.069   29.551  -11.888 1.000 35.225  0 176 GLN B OE1 1 ? 
ATOM   2608 N  NE2 . GLN B 1 153 ? 5.481   31.696  -11.784 1.000 26.750  0 176 GLN B NE2 1 ? 
ATOM   2609 N  N   . ARG B 1 154 ? 9.229   34.345  -8.774  1.000 23.307  0 177 ARG B N   1 ? 
ATOM   2610 C  CA  . ARG B 1 154 ? 9.004   35.064  -7.537  1.000 26.720  0 177 ARG B CA  1 ? 
ATOM   2611 C  C   . ARG B 1 154 ? 7.513   35.404  -7.545  1.000 31.796  0 177 ARG B C   1 ? 
ATOM   2612 O  O   . ARG B 1 154 ? 7.051   36.035  -8.481  1.000 34.856  0 177 ARG B O   1 ? 
ATOM   2613 C  CB  . ARG B 1 154 ? 9.857   36.340  -7.384  1.000 28.400  0 177 ARG B CB  1 ? 
ATOM   2614 C  CG  . ARG B 1 154 ? 9.849   36.805  -5.926  1.000 31.695  0 177 ARG B CG  1 ? 
ATOM   2615 C  CD  . ARG B 1 154 ? 10.686  38.023  -5.541  1.000 37.098  0 177 ARG B CD  1 ? 
ATOM   2616 N  NE  . ARG B 1 154 ? 9.998   39.254  -5.921  1.000 34.104  0 177 ARG B NE  1 ? 
ATOM   2617 C  CZ  . ARG B 1 154 ? 10.462  40.473  -5.705  1.000 39.900  0 177 ARG B CZ  1 ? 
ATOM   2618 N  NH1 . ARG B 1 154 ? 9.843   41.503  -6.233  1.000 40.349  0 177 ARG B NH1 1 ? 
ATOM   2619 N  NH2 . ARG B 1 154 ? 11.562  40.667  -5.006  1.000 38.635  0 177 ARG B NH2 1 ? 
ATOM   2620 N  N   . LEU B 1 155 ? 6.771   34.839  -6.590  1.000 27.202  0 178 LEU B N   1 ? 
ATOM   2621 C  CA  . LEU B 1 155 ? 5.308   34.910  -6.522  1.000 27.356  0 178 LEU B CA  1 ? 
ATOM   2622 C  C   . LEU B 1 155 ? 4.943   35.837  -5.370  1.000 26.056  0 178 LEU B C   1 ? 
ATOM   2623 O  O   . LEU B 1 155 ? 5.085   35.464  -4.211  1.000 25.761  0 178 LEU B O   1 ? 
ATOM   2624 C  CB  . LEU B 1 155 ? 4.738   33.508  -6.283  1.000 29.601  0 178 LEU B CB  1 ? 
ATOM   2625 C  CG  . LEU B 1 155 ? 4.933   32.514  -7.424  1.000 34.571  0 178 LEU B CG  1 ? 
ATOM   2626 C  CD1 . LEU B 1 155 ? 4.254   31.191  -7.110  1.000 34.646  0 178 LEU B CD1 1 ? 
ATOM   2627 C  CD2 . LEU B 1 155 ? 4.456   33.087  -8.736  1.000 36.682  0 178 LEU B CD2 1 ? 
ATOM   2628 N  N   . ASP B 1 156 ? 4.614   37.073  -5.728  1.000 28.674  0 179 ASP B N   1 ? 
ATOM   2629 C  CA  . ASP B 1 156 ? 4.396   38.148  -4.780  1.000 29.585  0 179 ASP B CA  1 ? 
ATOM   2630 C  C   . ASP B 1 156 ? 5.492   38.171  -3.715  1.000 26.166  0 179 ASP B C   1 ? 
ATOM   2631 O  O   . ASP B 1 156 ? 5.236   38.119  -2.523  1.000 30.248  0 179 ASP B O   1 ? 
ATOM   2632 C  CB  . ASP B 1 156 ? 3.015   38.027  -4.119  1.000 31.276  0 179 ASP B CB  1 ? 
ATOM   2633 C  CG  . ASP B 1 156 ? 2.605   39.324  -3.446  1.000 33.959  0 179 ASP B CG  1 ? 
ATOM   2634 O  OD1 . ASP B 1 156 ? 3.104   40.386  -3.900  1.000 32.731  0 179 ASP B OD1 1 ? 
ATOM   2635 O  OD2 . ASP B 1 156 ? 1.953   39.243  -2.388  1.000 30.418  0 179 ASP B OD2 1 ? 
ATOM   2636 N  N   . GLY B 1 157 ? 6.742   38.209  -4.160  1.000 30.608  0 180 GLY B N   1 ? 
ATOM   2637 C  CA  . GLY B 1 157 ? 7.831   38.470  -3.237  1.000 33.011  0 180 GLY B CA  1 ? 
ATOM   2638 C  C   . GLY B 1 157 ? 8.467   37.202  -2.681  1.000 32.359  0 180 GLY B C   1 ? 
ATOM   2639 O  O   . GLY B 1 157 ? 9.482   37.295  -1.980  1.000 29.555  0 180 GLY B O   1 ? 
ATOM   2640 N  N   . LYS B 1 158 ? 7.850   36.031  -2.943  1.000 28.208  0 181 LYS B N   1 ? 
ATOM   2641 C  CA  . LYS B 1 158 ? 8.369   34.786  -2.395  1.000 31.870  0 181 LYS B CA  1 ? 
ATOM   2642 C  C   . LYS B 1 158 ? 8.722   33.823  -3.534  1.000 30.514  0 181 LYS B C   1 ? 
ATOM   2643 O  O   . LYS B 1 158 ? 7.874   33.429  -4.334  1.000 26.858  0 181 LYS B O   1 ? 
ATOM   2644 C  CB  . LYS B 1 158 ? 7.391   34.169  -1.387  1.000 39.033  0 181 LYS B CB  1 ? 
ATOM   2645 C  CG  . LYS B 1 158 ? 7.791   32.783  -0.914  1.000 47.220  0 181 LYS B CG  1 ? 
ATOM   2646 C  CD  . LYS B 1 158 ? 7.038   32.275  0.278   1.000 62.992  0 181 LYS B CD  1 ? 
ATOM   2647 C  CE  . LYS B 1 158 ? 7.756   32.507  1.589   1.000 65.502  0 181 LYS B CE  1 ? 
ATOM   2648 N  NZ  . LYS B 1 158 ? 6.885   32.125  2.720   1.000 72.127  0 181 LYS B NZ  1 ? 
ATOM   2649 N  N   . THR B 1 159 ? 10.001  33.412  -3.580  1.000 24.438  0 182 THR B N   1 ? 
ATOM   2650 C  CA  . THR B 1 159 ? 10.491  32.636  -4.713  1.000 23.159  0 182 THR B CA  1 ? 
ATOM   2651 C  C   . THR B 1 159 ? 10.127  31.173  -4.489  1.000 21.770  0 182 THR B C   1 ? 
ATOM   2652 O  O   . THR B 1 159 ? 10.223  30.657  -3.363  1.000 24.046  0 182 THR B O   1 ? 
ATOM   2653 C  CB  . THR B 1 159 ? 12.016  32.804  -4.874  1.000 25.485  0 182 THR B CB  1 ? 
ATOM   2654 O  OG1 . THR B 1 159 ? 12.216  34.192  -5.106  1.000 27.234  0 182 THR B OG1 1 ? 
ATOM   2655 C  CG2 . THR B 1 159 ? 12.558  31.957  -6.015  1.000 22.830  0 182 THR B CG2 1 ? 
ATOM   2656 N  N   . VAL B 1 160 ? 9.756   30.509  -5.579  1.000 22.500  0 183 VAL B N   1 ? 
ATOM   2657 C  CA  . VAL B 1 160 ? 9.517   29.073  -5.560  1.000 22.737  0 183 VAL B CA  1 ? 
ATOM   2658 C  C   . VAL B 1 160 ? 10.261  28.451  -6.720  1.000 19.745  0 183 VAL B C   1 ? 
ATOM   2659 O  O   . VAL B 1 160 ? 10.529  29.110  -7.712  1.000 20.492  0 183 VAL B O   1 ? 
ATOM   2660 C  CB  . VAL B 1 160 ? 8.030   28.684  -5.641  1.000 24.654  0 183 VAL B CB  1 ? 
ATOM   2661 C  CG1 . VAL B 1 160 ? 7.223   29.200  -4.456  1.000 28.088  0 183 VAL B CG1 1 ? 
ATOM   2662 C  CG2 . VAL B 1 160 ? 7.408   29.087  -6.961  1.000 24.283  0 183 VAL B CG2 1 ? 
ATOM   2663 N  N   . TRP B 1 161 ? 10.470  27.140  -6.588  1.000 19.302  0 184 TRP B N   1 ? 
ATOM   2664 C  CA  . TRP B 1 161 ? 10.914  26.302  -7.678  1.000 20.288  0 184 TRP B CA  1 ? 
ATOM   2665 C  C   . TRP B 1 161 ? 9.745   25.416  -8.079  1.000 21.799  0 184 TRP B C   1 ? 
ATOM   2666 O  O   . TRP B 1 161 ? 9.084   24.870  -7.215  1.000 21.045  0 184 TRP B O   1 ? 
ATOM   2667 C  CB  . TRP B 1 161 ? 12.044  25.406  -7.168  1.000 19.696  0 184 TRP B CB  1 ? 
ATOM   2668 C  CG  . TRP B 1 161 ? 13.372  26.080  -6.976  1.000 20.086  0 184 TRP B CG  1 ? 
ATOM   2669 C  CD1 . TRP B 1 161 ? 13.692  27.413  -6.975  1.000 19.654  0 184 TRP B CD1 1 ? 
ATOM   2670 C  CD2 . TRP B 1 161 ? 14.589  25.364  -6.752  1.000 19.109  0 184 TRP B CD2 1 ? 
ATOM   2671 N  NE1 . TRP B 1 161 ? 15.034  27.570  -6.810  1.000 21.065  0 184 TRP B NE1 1 ? 
ATOM   2672 C  CE2 . TRP B 1 161 ? 15.610  26.325  -6.635  1.000 20.120  0 184 TRP B CE2 1 ? 
ATOM   2673 C  CE3 . TRP B 1 161 ? 14.893  24.008  -6.593  1.000 19.151  0 184 TRP B CE3 1 ? 
ATOM   2674 C  CZ2 . TRP B 1 161 ? 16.931  25.964  -6.429  1.000 20.468  0 184 TRP B CZ2 1 ? 
ATOM   2675 C  CZ3 . TRP B 1 161 ? 16.205  23.655  -6.364  1.000 19.419  0 184 TRP B CZ3 1 ? 
ATOM   2676 C  CH2 . TRP B 1 161 ? 17.213  24.615  -6.340  1.000 20.063  0 184 TRP B CH2 1 ? 
ATOM   2677 N  N   . GLN B 1 162 ? 9.510   25.218  -9.375  1.000 21.493  0 185 GLN B N   1 ? 
ATOM   2678 C  CA  . GLN B 1 162 ? 8.548   24.220  -9.808  1.000 21.197  0 185 GLN B CA  1 ? 
ATOM   2679 C  C   . GLN B 1 162 ? 9.249   23.176  -10.661 1.000 24.044  0 185 GLN B C   1 ? 
ATOM   2680 O  O   . GLN B 1 162 ? 10.043  23.546  -11.518 1.000 22.638  0 185 GLN B O   1 ? 
ATOM   2681 C  CB  . GLN B 1 162 ? 7.498   24.913  -10.662 1.000 23.821  0 185 GLN B CB  1 ? 
ATOM   2682 C  CG  . GLN B 1 162 ? 6.600   25.839  -9.850  1.000 25.198  0 185 GLN B CG  1 ? 
ATOM   2683 C  CD  . GLN B 1 162 ? 5.739   26.708  -10.735 1.000 28.765  0 185 GLN B CD  1 ? 
ATOM   2684 O  OE1 . GLN B 1 162 ? 5.919   26.771  -11.947 1.000 28.829  0 185 GLN B OE1 1 ? 
ATOM   2685 N  NE2 . GLN B 1 162 ? 4.841   27.461  -10.105 1.000 31.607  0 185 GLN B NE2 1 ? 
ATOM   2686 N  N   . ALA B 1 163 ? 8.941   21.901  -10.445 1.000 19.623  0 186 ALA B N   1 ? 
ATOM   2687 C  CA  . ALA B 1 163 ? 9.512   20.843  -11.251 1.000 20.998  0 186 ALA B CA  1 ? 
ATOM   2688 C  C   . ALA B 1 163 ? 8.473   20.366  -12.257 1.000 21.024  0 186 ALA B C   1 ? 
ATOM   2689 O  O   . ALA B 1 163 ? 7.363   20.016  -11.878 1.000 22.864  0 186 ALA B O   1 ? 
ATOM   2690 C  CB  . ALA B 1 163 ? 9.949   19.714  -10.376 1.000 21.632  0 186 ALA B CB  1 ? 
ATOM   2691 N  N   . TYR B 1 164 ? 8.849   20.372  -13.541 1.000 19.079  0 187 TYR B N   1 ? 
ATOM   2692 C  CA  . TYR B 1 164 ? 8.078   19.818  -14.627 1.000 19.923  0 187 TYR B CA  1 ? 
ATOM   2693 C  C   . TYR B 1 164 ? 8.875   18.661  -15.210 1.000 21.145  0 187 TYR B C   1 ? 
ATOM   2694 O  O   . TYR B 1 164 ? 10.082  18.764  -15.457 1.000 20.911  0 187 TYR B O   1 ? 
ATOM   2695 C  CB  . TYR B 1 164 ? 7.804   20.829  -15.740 1.000 21.325  0 187 TYR B CB  1 ? 
ATOM   2696 C  CG  . TYR B 1 164 ? 7.022   22.049  -15.290 1.000 21.866  0 187 TYR B CG  1 ? 
ATOM   2697 C  CD1 . TYR B 1 164 ? 7.632   23.122  -14.634 1.000 22.076  0 187 TYR B CD1 1 ? 
ATOM   2698 C  CD2 . TYR B 1 164 ? 5.650   22.116  -15.468 1.000 23.641  0 187 TYR B CD2 1 ? 
ATOM   2699 C  CE1 . TYR B 1 164 ? 6.912   24.227  -14.217 1.000 22.235  0 187 TYR B CE1 1 ? 
ATOM   2700 C  CE2 . TYR B 1 164 ? 4.933   23.234  -15.080 1.000 24.435  0 187 TYR B CE2 1 ? 
ATOM   2701 C  CZ  . TYR B 1 164 ? 5.552   24.278  -14.422 1.000 22.250  0 187 TYR B CZ  1 ? 
ATOM   2702 O  OH  . TYR B 1 164 ? 4.837   25.365  -13.972 1.000 24.976  0 187 TYR B OH  1 ? 
ATOM   2703 N  N   . LYS B 1 165 ? 8.190   17.534  -15.369 1.000 19.298  0 188 LYS B N   1 ? 
ATOM   2704 C  CA  . LYS B 1 165 ? 8.792   16.327  -15.875 1.000 20.995  0 188 LYS B CA  1 ? 
ATOM   2705 C  C   . LYS B 1 165 ? 7.824   15.604  -16.791 1.000 23.358  0 188 LYS B C   1 ? 
ATOM   2706 O  O   . LYS B 1 165 ? 6.639   15.506  -16.464 1.000 23.899  0 188 LYS B O   1 ? 
ATOM   2707 C  CB  . LYS B 1 165 ? 9.111   15.387  -14.708 1.000 21.083  0 188 LYS B CB  1 ? 
ATOM   2708 C  CG  . LYS B 1 165 ? 10.290  15.840  -13.898 1.000 27.989  0 188 LYS B CG  1 ? 
ATOM   2709 C  CD  . LYS B 1 165 ? 10.548  14.919  -12.730 1.000 27.515  0 188 LYS B CD  1 ? 
ATOM   2710 C  CE  . LYS B 1 165 ? 9.765   15.363  -11.530 1.000 32.256  0 188 LYS B CE  1 ? 
ATOM   2711 N  NZ  . LYS B 1 165 ? 9.935   14.400  -10.423 1.000 32.242  0 188 LYS B NZ  1 ? 
ATOM   2712 N  N   . ASN B 1 166 ? 8.337   15.197  -17.957 1.000 20.538  0 189 ASN B N   1 ? 
ATOM   2713 C  CA  . ASN B 1 166 ? 7.600   14.313  -18.847 1.000 23.973  0 189 ASN B CA  1 ? 
ATOM   2714 C  C   . ASN B 1 166 ? 8.470   13.117  -19.242 1.000 24.022  0 189 ASN B C   1 ? 
ATOM   2715 O  O   . ASN B 1 166 ? 9.686   13.231  -19.384 1.000 21.358  0 189 ASN B O   1 ? 
ATOM   2716 C  CB  . ASN B 1 166 ? 7.205   14.983  -20.168 1.000 24.591  0 189 ASN B CB  1 ? 
ATOM   2717 C  CG  . ASN B 1 166 ? 6.413   16.282  -20.076 1.000 22.962  0 189 ASN B CG  1 ? 
ATOM   2718 O  OD1 . ASN B 1 166 ? 6.523   17.120  -20.965 1.000 24.124  0 189 ASN B OD1 1 ? 
ATOM   2719 N  ND2 . ASN B 1 166 ? 5.660   16.513  -19.015 1.000 21.489  0 189 ASN B ND2 1 ? 
ATOM   2720 N  N   A CYS B 1 167 ? 7.829   11.939  -19.362 0.700 22.399  0 190 CYS B N   1 ? 
ATOM   2721 N  N   B CYS B 1 167 ? 7.816   11.967  -19.429 0.300 25.449  0 190 CYS B N   1 ? 
ATOM   2722 C  CA  A CYS B 1 167 ? 8.440   10.776  -19.997 0.700 23.511  0 190 CYS B CA  1 ? 
ATOM   2723 C  CA  B CYS B 1 167 ? 8.451   10.798  -20.011 0.300 27.653  0 190 CYS B CA  1 ? 
ATOM   2724 C  C   A CYS B 1 167 ? 7.583   10.372  -21.192 0.700 24.047  0 190 CYS B C   1 ? 
ATOM   2725 C  C   B CYS B 1 167 ? 7.594   10.320  -21.175 0.300 25.797  0 190 CYS B C   1 ? 
ATOM   2726 O  O   A CYS B 1 167 ? 6.356   10.326  -21.082 0.700 25.922  0 190 CYS B O   1 ? 
ATOM   2727 O  O   B CYS B 1 167 ? 6.392   10.123  -21.007 0.300 26.219  0 190 CYS B O   1 ? 
ATOM   2728 C  CB  A CYS B 1 167 ? 8.538   9.604   -19.035 0.700 25.257  0 190 CYS B CB  1 ? 
ATOM   2729 C  CB  B CYS B 1 167 ? 8.510   9.658   -19.015 0.300 32.003  0 190 CYS B CB  1 ? 
ATOM   2730 S  SG  A CYS B 1 167 ? 9.618   9.913   -17.611 0.700 28.019  0 190 CYS B SG  1 ? 
ATOM   2731 S  SG  B CYS B 1 167 ? 6.861   8.964   -18.774 0.300 44.034  0 190 CYS B SG  1 ? 
ATOM   2732 N  N   . ILE B 1 168 ? 8.230   10.105  -22.327 1.000 22.952  0 191 ILE B N   1 ? 
ATOM   2733 C  CA  . ILE B 1 168 ? 7.530   9.904   -23.587 1.000 23.627  0 191 ILE B CA  1 ? 
ATOM   2734 C  C   . ILE B 1 168 ? 8.230   8.770   -24.313 1.000 22.705  0 191 ILE B C   1 ? 
ATOM   2735 O  O   . ILE B 1 168 ? 9.337   8.901   -24.828 1.000 24.485  0 191 ILE B O   1 ? 
ATOM   2736 C  CB  . ILE B 1 168 ? 7.483   11.163  -24.456 1.000 25.625  0 191 ILE B CB  1 ? 
ATOM   2737 C  CG1 . ILE B 1 168 ? 6.982   12.382  -23.674 1.000 29.751  0 191 ILE B CG1 1 ? 
ATOM   2738 C  CG2 . ILE B 1 168 ? 6.667   10.856  -25.692 1.000 28.620  0 191 ILE B CG2 1 ? 
ATOM   2739 C  CD1 . ILE B 1 168 ? 6.933   13.685  -24.438 1.000 30.794  0 191 ILE B CD1 1 ? 
ATOM   2740 N  N   . PRO B 1 169 ? 7.618   7.575   -24.342 1.000 23.652  0 192 PRO B N   1 ? 
ATOM   2741 C  CA  . PRO B 1 169 ? 8.251   6.463   -25.026 1.000 25.398  0 192 PRO B CA  1 ? 
ATOM   2742 C  C   . PRO B 1 169 ? 8.171   6.655   -26.530 1.000 23.015  0 192 PRO B C   1 ? 
ATOM   2743 O  O   . PRO B 1 169 ? 7.140   7.052   -27.032 1.000 26.479  0 192 PRO B O   1 ? 
ATOM   2744 C  CB  . PRO B 1 169 ? 7.486   5.236   -24.512 1.000 27.437  0 192 PRO B CB  1 ? 
ATOM   2745 C  CG  . PRO B 1 169 ? 6.181   5.774   -24.043 1.000 28.076  0 192 PRO B CG  1 ? 
ATOM   2746 C  CD  . PRO B 1 169 ? 6.405   7.213   -23.599 1.000 25.433  0 192 PRO B CD  1 ? 
ATOM   2747 N  N   . LEU B 1 170 ? 9.291   6.371   -27.194 1.000 25.135  0 193 LEU B N   1 ? 
ATOM   2748 C  CA  . LEU B 1 170 ? 9.431   6.550   -28.624 1.000 24.731  0 193 LEU B CA  1 ? 
ATOM   2749 C  C   . LEU B 1 170 ? 9.699   5.195   -29.269 1.000 27.431  0 193 LEU B C   1 ? 
ATOM   2750 O  O   . LEU B 1 170 ? 10.349  4.349   -28.682 1.000 28.944  0 193 LEU B O   1 ? 
ATOM   2751 C  CB  . LEU B 1 170 ? 10.616  7.478   -28.897 1.000 26.899  0 193 LEU B CB  1 ? 
ATOM   2752 C  CG  . LEU B 1 170 ? 10.465  8.878   -28.330 1.000 24.880  0 193 LEU B CG  1 ? 
ATOM   2753 C  CD1 . LEU B 1 170 ? 11.667  9.724   -28.711 1.000 27.013  0 193 LEU B CD1 1 ? 
ATOM   2754 C  CD2 . LEU B 1 170 ? 9.174   9.561   -28.744 1.000 28.493  0 193 LEU B CD2 1 ? 
ATOM   2755 N  N   . THR B 1 171 ? 9.296   5.027   -30.530 1.000 31.926  0 194 THR B N   1 ? 
ATOM   2756 C  CA  . THR B 1 171 ? 9.770   3.870   -31.283 1.000 34.745  0 194 THR B CA  1 ? 
ATOM   2757 C  C   . THR B 1 171 ? 11.158  4.188   -31.846 1.000 43.192  0 194 THR B C   1 ? 
ATOM   2758 O  O   . THR B 1 171 ? 11.511  5.362   -32.029 1.000 40.483  0 194 THR B O   1 ? 
ATOM   2759 C  CB  . THR B 1 171 ? 8.751   3.517   -32.370 1.000 37.698  0 194 THR B CB  1 ? 
ATOM   2760 O  OG1 . THR B 1 171 ? 8.608   4.658   -33.199 1.000 37.141  0 194 THR B OG1 1 ? 
ATOM   2761 C  CG2 . THR B 1 171 ? 7.386   3.191   -31.820 1.000 37.389  0 194 THR B CG2 1 ? 
ATOM   2762 N  N   . GLY B 1 172 ? 11.958  3.151   -32.118 1.000 47.489  0 195 GLY B N   1 ? 
ATOM   2763 C  CA  . GLY B 1 172 ? 13.288  3.344   -32.700 1.000 58.521  0 195 GLY B CA  1 ? 
ATOM   2764 C  C   . GLY B 1 172 ? 13.230  4.016   -34.078 1.000 62.827  0 195 GLY B C   1 ? 
ATOM   2765 O  O   . GLY B 1 172 ? 12.239  3.861   -34.783 1.000 54.248  0 195 GLY B O   1 ? 
ATOM   2766 N  N   . PRO B 1 173 ? 14.279  4.753   -34.536 1.000 83.327  0 196 PRO B N   1 ? 
ATOM   2767 C  CA  . PRO B 1 173 ? 14.162  5.669   -35.679 1.000 88.071  0 196 PRO B CA  1 ? 
ATOM   2768 C  C   . PRO B 1 173 ? 14.394  5.009   -37.051 1.000 81.020  0 196 PRO B C   1 ? 
ATOM   2769 O  O   . PRO B 1 173 ? 15.272  4.165   -37.114 1.000 79.459  0 196 PRO B O   1 ? 
ATOM   2770 C  CB  . PRO B 1 173 ? 15.260  6.704   -35.383 1.000 85.281  0 196 PRO B CB  1 ? 
ATOM   2771 C  CG  . PRO B 1 173 ? 16.346  5.904   -34.673 1.000 83.579  0 196 PRO B CG  1 ? 
ATOM   2772 C  CD  . PRO B 1 173 ? 15.646  4.731   -34.005 1.000 83.371  0 196 PRO B CD  1 ? 
HETATM 2773 C  C1  A EDO C 2 .   ? 32.551  -8.296  5.235   0.500 47.075  0 301 EDO A C1  1 ? 
HETATM 2774 C  C1  B EDO C 2 .   ? 31.251  -8.432  4.266   0.500 32.693  0 301 EDO A C1  1 ? 
HETATM 2775 O  O1  A EDO C 2 .   ? 33.946  -8.275  5.448   0.500 46.834  0 301 EDO A O1  1 ? 
HETATM 2776 O  O1  B EDO C 2 .   ? 31.075  -9.174  5.450   0.500 29.965  0 301 EDO A O1  1 ? 
HETATM 2777 C  C2  A EDO C 2 .   ? 32.068  -7.204  4.348   0.500 46.180  0 301 EDO A C2  1 ? 
HETATM 2778 C  C2  B EDO C 2 .   ? 32.593  -8.623  3.662   0.500 34.182  0 301 EDO A C2  1 ? 
HETATM 2779 O  O2  A EDO C 2 .   ? 31.373  -7.680  3.195   0.500 47.674  0 301 EDO A O2  1 ? 
HETATM 2780 O  O2  B EDO C 2 .   ? 32.542  -9.108  2.343   0.500 36.219  0 301 EDO A O2  1 ? 
HETATM 2781 CU CU  . CU  D 3 .   ? 25.085  -5.445  2.177   1.000 29.712  0 302 CU  A CU  1 ? 
HETATM 2782 C  C1  . EDO E 2 .   ? 15.259  -6.218  14.495  1.000 57.110  0 303 EDO A C1  1 ? 
HETATM 2783 O  O1  . EDO E 2 .   ? 16.185  -5.593  13.582  1.000 46.775  0 303 EDO A O1  1 ? 
HETATM 2784 C  C2  . EDO E 2 .   ? 14.036  -6.835  13.856  1.000 58.149  0 303 EDO A C2  1 ? 
HETATM 2785 O  O2  . EDO E 2 .   ? 12.852  -6.005  13.829  1.000 51.602  0 303 EDO A O2  1 ? 
HETATM 2786 S  S   . SO4 F 4 .   ? 33.058  -7.863  -2.599  1.000 77.243  0 304 SO4 A S   1 ? 
HETATM 2787 O  O1  . SO4 F 4 .   ? 34.293  -7.989  -1.864  1.000 74.307  0 304 SO4 A O1  1 ? 
HETATM 2788 O  O2  . SO4 F 4 .   ? 33.231  -6.970  -3.730  1.000 63.330  0 304 SO4 A O2  1 ? 
HETATM 2789 O  O3  . SO4 F 4 .   ? 32.684  -9.172  -3.052  1.000 58.007  0 304 SO4 A O3  1 ? 
HETATM 2790 O  O4  . SO4 F 4 .   ? 32.025  -7.317  -1.743  1.000 78.875  0 304 SO4 A O4  1 ? 
HETATM 2791 S  S   . SO4 G 4 .   ? 29.756  -3.616  7.502   1.000 61.423  0 305 SO4 A S   1 ? 
HETATM 2792 O  O1  . SO4 G 4 .   ? 30.348  -2.417  6.939   1.000 52.339  0 305 SO4 A O1  1 ? 
HETATM 2793 O  O2  . SO4 G 4 .   ? 28.770  -4.123  6.585   1.000 62.297  0 305 SO4 A O2  1 ? 
HETATM 2794 O  O3  . SO4 G 4 .   ? 30.760  -4.640  7.722   1.000 66.087  0 305 SO4 A O3  1 ? 
HETATM 2795 O  O4  . SO4 G 4 .   ? 29.137  -3.277  8.767   1.000 68.342  0 305 SO4 A O4  1 ? 
HETATM 2796 C  C1  . GOL H 5 .   ? -1.484  23.070  -22.032 1.000 54.075  0 301 GOL B C1  1 ? 
HETATM 2797 O  O1  . GOL H 5 .   ? -0.464  23.982  -22.419 1.000 46.646  0 301 GOL B O1  1 ? 
HETATM 2798 C  C2  . GOL H 5 .   ? -2.718  23.366  -22.822 1.000 58.049  0 301 GOL B C2  1 ? 
HETATM 2799 O  O2  . GOL H 5 .   ? -2.818  24.788  -22.891 1.000 60.150  0 301 GOL B O2  1 ? 
HETATM 2800 C  C3  . GOL H 5 .   ? -2.691  22.735  -24.201 1.000 59.627  0 301 GOL B C3  1 ? 
HETATM 2801 O  O3  . GOL H 5 .   ? -3.303  21.443  -24.200 1.000 48.124  0 301 GOL B O3  1 ? 
HETATM 2802 CU CU  . CU  I 3 .   ? 3.408   27.995  -14.940 1.000 31.905  0 302 CU  B CU  1 ? 
HETATM 2803 O  O   . HOH J 6 .   ? 11.951  -10.890 -19.613 1.000 35.689  0 401 HOH A O   1 ? 
HETATM 2804 O  O   . HOH J 6 .   ? 14.016  -17.366 -23.691 1.000 45.549  0 402 HOH A O   1 ? 
HETATM 2805 O  O   . HOH J 6 .   ? 13.535  -21.093 -27.348 1.000 53.879  0 403 HOH A O   1 ? 
HETATM 2806 O  O   . HOH J 6 .   ? 13.861  -9.662  8.502   1.000 36.006  0 404 HOH A O   1 ? 
HETATM 2807 O  O   . HOH J 6 .   ? 19.765  -21.213 4.275   1.000 42.695  0 405 HOH A O   1 ? 
HETATM 2808 O  O   . HOH J 6 .   ? 17.046  -1.814  -12.834 1.000 35.341  0 406 HOH A O   1 ? 
HETATM 2809 O  O   . HOH J 6 .   ? 31.477  -5.375  2.307   1.000 48.559  0 407 HOH A O   1 ? 
HETATM 2810 O  O   . HOH J 6 .   ? 19.288  -6.888  9.391   1.000 38.973  0 408 HOH A O   1 ? 
HETATM 2811 O  O   . HOH J 6 .   ? 29.627  0.405   -3.595  1.000 38.860  0 409 HOH A O   1 ? 
HETATM 2812 O  O   . HOH J 6 .   ? 18.764  11.708  -3.500  1.000 43.582  0 410 HOH A O   1 ? 
HETATM 2813 O  O   . HOH J 6 .   ? 5.752   -7.281  -12.835 1.000 44.114  0 411 HOH A O   1 ? 
HETATM 2814 O  O   . HOH J 6 .   ? 5.631   7.872   -5.824  1.000 43.577  0 412 HOH A O   1 ? 
HETATM 2815 O  O   . HOH J 6 .   ? 10.257  -5.140  -16.959 1.000 45.203  0 413 HOH A O   1 ? 
HETATM 2816 O  O   . HOH J 6 .   ? 22.284  -6.310  9.135   1.000 50.583  0 414 HOH A O   1 ? 
HETATM 2817 O  O   . HOH J 6 .   ? 31.318  -12.308 -18.732 1.000 31.524  0 415 HOH A O   1 ? 
HETATM 2818 O  O   . HOH J 6 .   ? 9.604   -22.300 -14.595 1.000 29.754  0 416 HOH A O   1 ? 
HETATM 2819 O  O   . HOH J 6 .   ? 28.324  -0.311  -6.066  1.000 35.348  0 417 HOH A O   1 ? 
HETATM 2820 O  O   . HOH J 6 .   ? -2.506  -1.024  4.102   1.000 43.016  0 418 HOH A O   1 ? 
HETATM 2821 O  O   . HOH J 6 .   ? 24.029  -10.481 2.870   1.000 27.950  0 419 HOH A O   1 ? 
HETATM 2822 O  O   . HOH J 6 .   ? 9.847   9.546   -5.503  1.000 40.521  0 420 HOH A O   1 ? 
HETATM 2823 O  O   . HOH J 6 .   ? 10.888  -19.606 4.156   1.000 44.569  0 421 HOH A O   1 ? 
HETATM 2824 O  O   . HOH J 6 .   ? 29.623  -1.313  -0.481  1.000 36.633  0 422 HOH A O   1 ? 
HETATM 2825 O  O   . HOH J 6 .   ? 16.814  -3.789  -14.481 1.000 29.482  0 423 HOH A O   1 ? 
HETATM 2826 O  O   . HOH J 6 .   ? 15.661  -21.687 2.464   1.000 29.617  0 424 HOH A O   1 ? 
HETATM 2827 O  O   . HOH J 6 .   ? 27.571  -22.780 -21.883 1.000 32.623  0 425 HOH A O   1 ? 
HETATM 2828 O  O   . HOH J 6 .   ? 19.718  -28.478 -15.296 1.000 45.935  0 426 HOH A O   1 ? 
HETATM 2829 O  O   . HOH J 6 .   ? 7.858   -7.236  -3.462  1.000 33.811  0 427 HOH A O   1 ? 
HETATM 2830 O  O   . HOH J 6 .   ? 10.882  4.419   -7.648  1.000 23.575  0 428 HOH A O   1 ? 
HETATM 2831 O  O   . HOH J 6 .   ? 30.645  -1.603  10.115  1.000 56.984  0 429 HOH A O   1 ? 
HETATM 2832 O  O   . HOH J 6 .   ? 22.672  -22.968 3.673   1.000 44.404  0 430 HOH A O   1 ? 
HETATM 2833 O  O   . HOH J 6 .   ? 17.576  8.098   12.976  1.000 46.383  0 431 HOH A O   1 ? 
HETATM 2834 O  O   . HOH J 6 .   ? 31.664  -16.630 -13.679 1.000 48.007  0 432 HOH A O   1 ? 
HETATM 2835 O  O   . HOH J 6 .   ? 20.754  6.284   -8.518  1.000 31.150  0 433 HOH A O   1 ? 
HETATM 2836 O  O   . HOH J 6 .   ? 18.095  -4.413  7.185   1.000 20.802  0 434 HOH A O   1 ? 
HETATM 2837 O  O   . HOH J 6 .   ? 16.357  -0.388  -16.118 1.000 37.141  0 435 HOH A O   1 ? 
HETATM 2838 O  O   . HOH J 6 .   ? 17.259  0.605   -13.627 1.000 32.186  0 436 HOH A O   1 ? 
HETATM 2839 O  O   . HOH J 6 .   ? 10.355  3.228   -10.188 1.000 26.859  0 437 HOH A O   1 ? 
HETATM 2840 O  O   . HOH J 6 .   ? 4.344   -12.605 -1.072  1.000 45.437  0 438 HOH A O   1 ? 
HETATM 2841 O  O   . HOH J 6 .   ? 22.292  -24.996 -1.912  1.000 39.683  0 439 HOH A O   1 ? 
HETATM 2842 O  O   . HOH J 6 .   ? 8.031   -20.392 -6.097  1.000 27.466  0 440 HOH A O   1 ? 
HETATM 2843 O  O   . HOH J 6 .   ? 18.984  -14.368 6.216   1.000 27.817  0 441 HOH A O   1 ? 
HETATM 2844 O  O   . HOH J 6 .   ? 7.082   -5.665  9.784   1.000 30.195  0 442 HOH A O   1 ? 
HETATM 2845 O  O   . HOH J 6 .   ? 24.482  -8.889  -6.397  1.000 21.863  0 443 HOH A O   1 ? 
HETATM 2846 O  O   . HOH J 6 .   ? 25.720  -13.805 -15.717 1.000 23.690  0 444 HOH A O   1 ? 
HETATM 2847 O  O   . HOH J 6 .   ? 9.449   -19.378 -0.660  1.000 29.079  0 445 HOH A O   1 ? 
HETATM 2848 O  O   . HOH J 6 .   ? 9.940   -13.585 4.801   1.000 37.934  0 446 HOH A O   1 ? 
HETATM 2849 O  O   . HOH J 6 .   ? 27.590  -17.772 -16.167 1.000 29.732  0 447 HOH A O   1 ? 
HETATM 2850 O  O   . HOH J 6 .   ? 30.066  -17.370 1.497   1.000 26.212  0 448 HOH A O   1 ? 
HETATM 2851 O  O   . HOH J 6 .   ? 20.906  -23.986 -5.804  1.000 28.359  0 449 HOH A O   1 ? 
HETATM 2852 O  O   . HOH J 6 .   ? 28.950  -19.037 -8.402  1.000 35.548  0 450 HOH A O   1 ? 
HETATM 2853 O  O   . HOH J 6 .   ? -0.986  2.413   2.961   1.000 26.544  0 451 HOH A O   1 ? 
HETATM 2854 O  O   . HOH J 6 .   ? 24.786  -15.366 -22.586 1.000 27.702  0 452 HOH A O   1 ? 
HETATM 2855 O  O   . HOH J 6 .   ? 12.530  10.081  -5.922  1.000 28.996  0 453 HOH A O   1 ? 
HETATM 2856 O  O   . HOH J 6 .   ? 9.221   -1.216  -14.908 1.000 41.368  0 454 HOH A O   1 ? 
HETATM 2857 O  O   . HOH J 6 .   ? 21.616  -16.254 6.481   1.000 26.980  0 455 HOH A O   1 ? 
HETATM 2858 O  O   . HOH J 6 .   ? 13.614  9.808   1.217   1.000 27.987  0 456 HOH A O   1 ? 
HETATM 2859 O  O   . HOH J 6 .   ? 23.703  6.790   0.733   1.000 46.665  0 457 HOH A O   1 ? 
HETATM 2860 O  O   . HOH J 6 .   ? 8.699   -5.934  1.537   1.000 23.225  0 458 HOH A O   1 ? 
HETATM 2861 O  O   . HOH J 6 .   ? 15.503  -27.874 -10.322 1.000 29.217  0 459 HOH A O   1 ? 
HETATM 2862 O  O   . HOH J 6 .   ? 4.366   -16.137 -11.848 1.000 36.961  0 460 HOH A O   1 ? 
HETATM 2863 O  O   . HOH J 6 .   ? 25.840  -21.212 9.847   1.000 37.599  0 461 HOH A O   1 ? 
HETATM 2864 O  O   . HOH J 6 .   ? 31.094  -15.893 -9.842  1.000 42.406  0 462 HOH A O   1 ? 
HETATM 2865 O  O   . HOH J 6 .   ? 16.658  -8.383  11.766  1.000 39.243  0 463 HOH A O   1 ? 
HETATM 2866 O  O   . HOH J 6 .   ? 15.912  -9.429  2.564   1.000 23.668  0 464 HOH A O   1 ? 
HETATM 2867 O  O   . HOH J 6 .   ? 7.573   5.268   11.113  1.000 45.752  0 465 HOH A O   1 ? 
HETATM 2868 O  O   . HOH J 6 .   ? 0.813   -2.946  0.902   1.000 39.009  0 466 HOH A O   1 ? 
HETATM 2869 O  O   . HOH J 6 .   ? 27.172  -20.159 -2.175  1.000 26.760  0 467 HOH A O   1 ? 
HETATM 2870 O  O   . HOH J 6 .   ? 9.465   -9.152  -4.148  1.000 29.345  0 468 HOH A O   1 ? 
HETATM 2871 O  O   . HOH J 6 .   ? 16.520  8.251   5.134   1.000 33.412  0 469 HOH A O   1 ? 
HETATM 2872 O  O   . HOH J 6 .   ? 14.255  -12.768 -16.411 1.000 23.909  0 470 HOH A O   1 ? 
HETATM 2873 O  O   . HOH J 6 .   ? 7.191   10.112  -1.724  1.000 47.802  0 471 HOH A O   1 ? 
HETATM 2874 O  O   . HOH J 6 .   ? 23.799  9.274   9.961   1.000 30.481  0 472 HOH A O   1 ? 
HETATM 2875 O  O   . HOH J 6 .   ? 6.017   2.090   -7.057  1.000 38.207  0 473 HOH A O   1 ? 
HETATM 2876 O  O   . HOH J 6 .   ? 26.297  0.270   -10.372 1.000 34.553  0 474 HOH A O   1 ? 
HETATM 2877 O  O   . HOH J 6 .   ? 7.377   -16.529 -0.807  1.000 26.817  0 475 HOH A O   1 ? 
HETATM 2878 O  O   . HOH J 6 .   ? -3.760  1.597   -2.347  1.000 48.582  0 476 HOH A O   1 ? 
HETATM 2879 O  O   . HOH J 6 .   ? 21.380  -0.537  -17.999 1.000 42.853  0 477 HOH A O   1 ? 
HETATM 2880 O  O   . HOH J 6 .   ? 7.137   -5.255  3.738   1.000 24.547  0 478 HOH A O   1 ? 
HETATM 2881 O  O   . HOH J 6 .   ? 20.542  -9.629  10.114  1.000 35.524  0 479 HOH A O   1 ? 
HETATM 2882 O  O   . HOH J 6 .   ? 14.838  -18.896 7.097   1.000 43.095  0 480 HOH A O   1 ? 
HETATM 2883 O  O   . HOH J 6 .   ? 8.895   -21.509 -9.131  1.000 25.323  0 481 HOH A O   1 ? 
HETATM 2884 O  O   . HOH J 6 .   ? 13.866  8.215   -13.122 1.000 39.965  0 482 HOH A O   1 ? 
HETATM 2885 O  O   . HOH J 6 .   ? 26.391  -5.559  6.563   1.000 47.708  0 483 HOH A O   1 ? 
HETATM 2886 O  O   . HOH J 6 .   ? 26.809  -7.719  -7.053  1.000 23.700  0 484 HOH A O   1 ? 
HETATM 2887 O  O   . HOH J 6 .   ? 5.004   -13.990 -13.848 1.000 30.927  0 485 HOH A O   1 ? 
HETATM 2888 O  O   . HOH J 6 .   ? 26.572  -11.733 9.697   1.000 35.923  0 486 HOH A O   1 ? 
HETATM 2889 O  O   . HOH J 6 .   ? 26.040  3.251   -7.685  1.000 35.625  0 487 HOH A O   1 ? 
HETATM 2890 O  O   . HOH J 6 .   ? 30.623  -14.996 -22.436 1.000 28.997  0 488 HOH A O   1 ? 
HETATM 2891 O  O   . HOH J 6 .   ? 27.737  -9.424  6.373   1.000 39.582  0 489 HOH A O   1 ? 
HETATM 2892 O  O   . HOH J 6 .   ? 14.447  -6.647  -17.586 1.000 43.181  0 490 HOH A O   1 ? 
HETATM 2893 O  O   . HOH J 6 .   ? 24.861  6.846   16.290  1.000 47.775  0 491 HOH A O   1 ? 
HETATM 2894 O  O   . HOH J 6 .   ? 6.006   -10.327 -16.917 1.000 41.676  0 492 HOH A O   1 ? 
HETATM 2895 O  O   . HOH J 6 .   ? 26.707  -9.679  3.920   1.000 34.421  0 493 HOH A O   1 ? 
HETATM 2896 O  O   . HOH J 6 .   ? 36.527  -10.340 -7.338  1.000 46.813  0 494 HOH A O   1 ? 
HETATM 2897 O  O   . HOH J 6 .   ? 10.123  -18.513 -18.416 1.000 29.464  0 495 HOH A O   1 ? 
HETATM 2898 O  O   . HOH J 6 .   ? 31.681  -6.960  -12.914 1.000 36.992  0 496 HOH A O   1 ? 
HETATM 2899 O  O   . HOH J 6 .   ? 24.817  1.659   11.306  1.000 41.663  0 497 HOH A O   1 ? 
HETATM 2900 O  O   . HOH J 6 .   ? 25.823  -22.937 -12.534 1.000 38.231  0 498 HOH A O   1 ? 
HETATM 2901 O  O   . HOH J 6 .   ? 30.964  -1.627  -6.291  1.000 45.577  0 499 HOH A O   1 ? 
HETATM 2902 O  O   . HOH J 6 .   ? 16.933  -2.017  10.951  1.000 43.306  0 500 HOH A O   1 ? 
HETATM 2903 O  O   . HOH J 6 .   ? 7.183   -6.328  -0.830  1.000 26.697  0 501 HOH A O   1 ? 
HETATM 2904 O  O   . HOH J 6 .   ? 11.836  -19.085 -20.858 1.000 40.187  0 502 HOH A O   1 ? 
HETATM 2905 O  O   . HOH J 6 .   ? 5.454   -7.898  -4.746  1.000 31.771  0 503 HOH A O   1 ? 
HETATM 2906 O  O   . HOH J 6 .   ? 5.046   -4.322  -0.634  1.000 31.680  0 504 HOH A O   1 ? 
HETATM 2907 O  O   . HOH J 6 .   ? 19.859  -26.421 -2.621  1.000 46.251  0 505 HOH A O   1 ? 
HETATM 2908 O  O   . HOH J 6 .   ? 19.283  8.155   2.793   1.000 31.830  0 506 HOH A O   1 ? 
HETATM 2909 O  O   . HOH J 6 .   ? 6.337   -2.029  -8.755  1.000 26.649  0 507 HOH A O   1 ? 
HETATM 2910 O  O   . HOH J 6 .   ? 26.451  -2.296  -11.368 1.000 31.167  0 508 HOH A O   1 ? 
HETATM 2911 O  O   . HOH J 6 .   ? 24.229  -26.637 -19.986 1.000 50.908  0 509 HOH A O   1 ? 
HETATM 2912 O  O   . HOH J 6 .   ? 8.175   4.605   -6.844  1.000 31.201  0 510 HOH A O   1 ? 
HETATM 2913 O  O   . HOH J 6 .   ? 15.636  -29.399 -2.797  1.000 44.936  0 511 HOH A O   1 ? 
HETATM 2914 O  O   . HOH J 6 .   ? 17.710  -6.920  -16.855 1.000 35.149  0 512 HOH A O   1 ? 
HETATM 2915 O  O   . HOH J 6 .   ? 21.524  2.686   12.483  1.000 36.843  0 513 HOH A O   1 ? 
HETATM 2916 O  O   . HOH J 6 .   ? 12.429  9.120   8.028   1.000 40.879  0 514 HOH A O   1 ? 
HETATM 2917 O  O   . HOH J 6 .   ? 15.828  -32.605 -11.475 1.000 44.593  0 515 HOH A O   1 ? 
HETATM 2918 O  O   . HOH J 6 .   ? 22.683  -28.561 -12.807 1.000 37.322  0 516 HOH A O   1 ? 
HETATM 2919 O  O   . HOH J 6 .   ? 14.692  -12.263 -21.015 1.000 41.591  0 517 HOH A O   1 ? 
HETATM 2920 O  O   . HOH J 6 .   ? 10.481  1.669   -13.446 1.000 44.820  0 518 HOH A O   1 ? 
HETATM 2921 O  O   . HOH J 6 .   ? 20.434  -13.205 12.912  1.000 48.658  0 519 HOH A O   1 ? 
HETATM 2922 O  O   . HOH J 6 .   ? 26.964  5.415   -0.847  1.000 46.780  0 520 HOH A O   1 ? 
HETATM 2923 O  O   . HOH J 6 .   ? 30.236  -17.937 -5.978  1.000 43.617  0 521 HOH A O   1 ? 
HETATM 2924 O  O   . HOH J 6 .   ? 29.417  -16.957 4.193   1.000 25.291  0 522 HOH A O   1 ? 
HETATM 2925 O  O   . HOH J 6 .   ? 12.443  -26.620 -3.648  1.000 48.345  0 523 HOH A O   1 ? 
HETATM 2926 O  O   . HOH J 6 .   ? 24.640  1.530   -12.355 1.000 29.642  0 524 HOH A O   1 ? 
HETATM 2927 O  O   . HOH J 6 .   ? 25.474  -7.312  -9.615  1.000 23.850  0 525 HOH A O   1 ? 
HETATM 2928 O  O   . HOH J 6 .   ? 15.000  -3.103  -17.699 1.000 43.029  0 526 HOH A O   1 ? 
HETATM 2929 O  O   . HOH J 6 .   ? 6.271   -12.639 1.469   1.000 27.113  0 527 HOH A O   1 ? 
HETATM 2930 O  O   . HOH J 6 .   ? 20.866  -4.508  7.526   1.000 29.657  0 528 HOH A O   1 ? 
HETATM 2931 O  O   . HOH J 6 .   ? 31.952  -17.000 -17.019 1.000 43.624  0 529 HOH A O   1 ? 
HETATM 2932 O  O   . HOH J 6 .   ? 19.297  -1.679  9.487   1.000 32.417  0 530 HOH A O   1 ? 
HETATM 2933 O  O   . HOH J 6 .   ? 5.157   8.005   0.286   1.000 31.466  0 531 HOH A O   1 ? 
HETATM 2934 O  O   . HOH J 6 .   ? 18.279  -6.200  -14.318 1.000 24.560  0 532 HOH A O   1 ? 
HETATM 2935 O  O   . HOH J 6 .   ? 13.119  -27.046 -11.658 1.000 41.126  0 533 HOH A O   1 ? 
HETATM 2936 O  O   . HOH J 6 .   ? 32.934  -13.842 -15.272 1.000 35.942  0 534 HOH A O   1 ? 
HETATM 2937 O  O   . HOH J 6 .   ? 21.955  -33.493 -10.290 1.000 45.929  0 535 HOH A O   1 ? 
HETATM 2938 O  O   . HOH J 6 .   ? 21.983  5.599   -11.222 1.000 54.808  0 536 HOH A O   1 ? 
HETATM 2939 O  O   . HOH J 6 .   ? 24.592  4.527   -5.699  1.000 26.945  0 537 HOH A O   1 ? 
HETATM 2940 O  O   . HOH J 6 .   ? 25.131  -22.535 5.462   1.000 34.555  0 538 HOH A O   1 ? 
HETATM 2941 O  O   . HOH J 6 .   ? 26.424  -25.526 -16.411 1.000 35.939  0 539 HOH A O   1 ? 
HETATM 2942 O  O   . HOH J 6 .   ? 16.297  -14.764 9.285   1.000 40.114  0 540 HOH A O   1 ? 
HETATM 2943 O  O   . HOH J 6 .   ? 18.154  -8.381  -12.600 1.000 22.858  0 541 HOH A O   1 ? 
HETATM 2944 O  O   . HOH J 6 .   ? 19.010  9.139   -3.609  1.000 34.807  0 542 HOH A O   1 ? 
HETATM 2945 O  O   . HOH J 6 .   ? 7.843   1.745   -11.478 1.000 51.423  0 543 HOH A O   1 ? 
HETATM 2946 O  O   . HOH J 6 .   ? 29.192  -5.166  3.816   1.000 41.743  0 544 HOH A O   1 ? 
HETATM 2947 O  O   . HOH J 6 .   ? 2.215   8.801   -2.838  1.000 48.793  0 545 HOH A O   1 ? 
HETATM 2948 O  O   . HOH J 6 .   ? 23.791  -5.639  -18.810 1.000 46.483  0 546 HOH A O   1 ? 
HETATM 2949 O  O   . HOH J 6 .   ? 6.621   -16.866 -5.102  1.000 27.651  0 547 HOH A O   1 ? 
HETATM 2950 O  O   . HOH J 6 .   ? 11.628  9.797   4.081   1.000 41.869  0 548 HOH A O   1 ? 
HETATM 2951 O  O   . HOH J 6 .   ? 23.901  -6.320  -7.123  1.000 21.667  0 549 HOH A O   1 ? 
HETATM 2952 O  O   . HOH J 6 .   ? 20.398  -3.568  -20.835 1.000 50.574  0 550 HOH A O   1 ? 
HETATM 2953 O  O   . HOH J 6 .   ? 1.890   -0.962  9.174   1.000 39.832  0 551 HOH A O   1 ? 
HETATM 2954 O  O   . HOH J 6 .   ? 16.262  -11.047 -22.174 1.000 57.512  0 552 HOH A O   1 ? 
HETATM 2955 O  O   . HOH J 6 .   ? 30.260  -14.003 -0.419  1.000 41.618  0 553 HOH A O   1 ? 
HETATM 2956 O  O   . HOH J 6 .   ? 16.680  -0.006  14.945  1.000 52.954  0 554 HOH A O   1 ? 
HETATM 2957 O  O   . HOH J 6 .   ? 22.596  7.228   15.054  1.000 43.317  0 555 HOH A O   1 ? 
HETATM 2958 O  O   . HOH J 6 .   ? 31.366  -14.434 -2.877  1.000 38.658  0 556 HOH A O   1 ? 
HETATM 2959 O  O   . HOH J 6 .   ? 3.290   -5.157  8.029   1.000 44.990  0 557 HOH A O   1 ? 
HETATM 2960 O  O   . HOH J 6 .   ? 21.840  -12.172 -23.532 1.000 46.904  0 558 HOH A O   1 ? 
HETATM 2961 O  O   . HOH J 6 .   ? 26.991  -21.926 -4.060  1.000 36.148  0 559 HOH A O   1 ? 
HETATM 2962 O  O   . HOH J 6 .   ? 4.083   -14.232 -16.094 1.000 46.037  0 560 HOH A O   1 ? 
HETATM 2963 O  O   . HOH J 6 .   ? 22.094  -26.338 -5.972  1.000 42.285  0 561 HOH A O   1 ? 
HETATM 2964 O  O   . HOH J 6 .   ? 20.750  -22.975 -24.299 1.000 78.478  0 562 HOH A O   1 ? 
HETATM 2965 O  O   . HOH J 6 .   ? 32.926  -12.898 -0.385  1.000 47.336  0 563 HOH A O   1 ? 
HETATM 2966 O  O   . HOH J 6 .   ? 27.693  -23.859 -14.132 1.000 46.625  0 564 HOH A O   1 ? 
HETATM 2967 O  O   . HOH J 6 .   ? 10.311  16.500  1.774   1.000 53.348  0 565 HOH A O   1 ? 
HETATM 2968 O  O   . HOH J 6 .   ? 0.835   -2.479  -1.962  1.000 49.684  0 566 HOH A O   1 ? 
HETATM 2969 O  O   . HOH J 6 .   ? 29.728  -18.423 -3.026  1.000 45.706  0 567 HOH A O   1 ? 
HETATM 2970 O  O   . HOH J 6 .   ? 8.059   -6.907  -14.785 1.000 49.109  0 568 HOH A O   1 ? 
HETATM 2971 O  O   . HOH J 6 .   ? 5.446   -14.893 0.327   1.000 32.603  0 569 HOH A O   1 ? 
HETATM 2972 O  O   . HOH J 6 .   ? 5.512   -5.844  7.498   1.000 40.042  0 570 HOH A O   1 ? 
HETATM 2973 O  O   . HOH J 6 .   ? 26.110  5.866   -3.661  1.000 46.994  0 571 HOH A O   1 ? 
HETATM 2974 O  O   . HOH J 6 .   ? 15.097  -12.215 9.700   1.000 64.775  0 572 HOH A O   1 ? 
HETATM 2975 O  O   . HOH J 6 .   ? 0.433   -9.665  8.427   1.000 52.308  0 573 HOH A O   1 ? 
HETATM 2976 O  O   . HOH J 6 .   ? 29.882  -19.158 -15.359 1.000 42.086  0 574 HOH A O   1 ? 
HETATM 2977 O  O   . HOH J 6 .   ? 14.388  -27.891 -16.416 1.000 61.501  0 575 HOH A O   1 ? 
HETATM 2978 O  O   . HOH J 6 .   ? 31.764  -16.897 -1.953  1.000 52.504  0 576 HOH A O   1 ? 
HETATM 2979 O  O   . HOH J 6 .   ? 25.074  -27.533 -12.911 1.000 45.605  0 577 HOH A O   1 ? 
HETATM 2980 O  O   . HOH J 6 .   ? 17.892  -2.118  13.804  1.000 50.238  0 578 HOH A O   1 ? 
HETATM 2981 O  O   . HOH J 6 .   ? 6.523   0.602   -9.288  1.000 38.081  0 579 HOH A O   1 ? 
HETATM 2982 O  O   . HOH J 6 .   ? 21.277  8.498   1.223   1.000 45.796  0 580 HOH A O   1 ? 
HETATM 2983 O  O   . HOH J 6 .   ? 11.983  11.697  1.558   1.000 47.740  0 581 HOH A O   1 ? 
HETATM 2984 O  O   . HOH J 6 .   ? 6.313   -7.138  5.193   1.000 34.325  0 582 HOH A O   1 ? 
HETATM 2985 O  O   . HOH J 6 .   ? 23.182  6.361   -7.139  1.000 36.700  0 583 HOH A O   1 ? 
HETATM 2986 O  O   . HOH J 6 .   ? 17.777  10.239  3.751   1.000 48.802  0 584 HOH A O   1 ? 
HETATM 2987 O  O   . HOH J 6 .   ? 2.740   9.057   0.024   1.000 36.079  0 585 HOH A O   1 ? 
HETATM 2988 O  O   . HOH J 6 .   ? 8.768   5.757   -13.417 1.000 46.316  0 586 HOH A O   1 ? 
HETATM 2989 O  O   . HOH J 6 .   ? 21.376  -5.846  -19.976 1.000 50.278  0 587 HOH A O   1 ? 
HETATM 2990 O  O   . HOH J 6 .   ? 2.950   -5.229  -1.951  1.000 45.636  0 588 HOH A O   1 ? 
HETATM 2991 O  O   . HOH J 6 .   ? 26.514  -9.060  8.839   1.000 54.831  0 589 HOH A O   1 ? 
HETATM 2992 O  O   . HOH J 6 .   ? 26.230  4.751   -9.653  1.000 50.418  0 590 HOH A O   1 ? 
HETATM 2993 O  O   . HOH J 6 .   ? 23.282  -16.721 -24.168 1.000 35.902  0 591 HOH A O   1 ? 
HETATM 2994 O  O   . HOH J 6 .   ? 24.221  4.194   -11.344 1.000 43.635  0 592 HOH A O   1 ? 
HETATM 2995 O  O   . HOH K 6 .   ? 22.314  12.392  -30.566 1.000 43.994  0 401 HOH B O   1 ? 
HETATM 2996 O  O   . HOH K 6 .   ? 17.694  36.218  -6.627  1.000 32.702  0 402 HOH B O   1 ? 
HETATM 2997 O  O   . HOH K 6 .   ? 16.527  2.105   -25.243 1.000 53.251  0 403 HOH B O   1 ? 
HETATM 2998 O  O   . HOH K 6 .   ? 12.235  13.638  -10.355 1.000 30.756  0 404 HOH B O   1 ? 
HETATM 2999 O  O   . HOH K 6 .   ? 20.990  23.185  -16.009 1.000 32.622  0 405 HOH B O   1 ? 
HETATM 3000 O  O   . HOH K 6 .   ? 1.399   35.870  -22.853 1.000 54.220  0 406 HOH B O   1 ? 
HETATM 3001 O  O   . HOH K 6 .   ? 14.505  19.251  0.825   1.000 50.447  0 407 HOH B O   1 ? 
HETATM 3002 O  O   . HOH K 6 .   ? 8.572   8.007   -9.364  1.000 46.621  0 408 HOH B O   1 ? 
HETATM 3003 O  O   . HOH K 6 .   ? 19.068  24.139  -28.078 1.000 35.410  0 409 HOH B O   1 ? 
HETATM 3004 O  O   . HOH K 6 .   ? 14.367  34.679  -19.399 1.000 41.076  0 410 HOH B O   1 ? 
HETATM 3005 O  O   . HOH K 6 .   ? 8.926   35.133  -16.922 1.000 37.790  0 411 HOH B O   1 ? 
HETATM 3006 O  O   . HOH K 6 .   ? 1.930   29.159  -19.302 1.000 39.375  0 412 HOH B O   1 ? 
HETATM 3007 O  O   . HOH K 6 .   ? 2.908   6.814   -24.691 1.000 37.135  0 413 HOH B O   1 ? 
HETATM 3008 O  O   . HOH K 6 .   ? 8.103   35.402  -20.034 1.000 46.668  0 414 HOH B O   1 ? 
HETATM 3009 O  O   . HOH K 6 .   ? 5.922   28.094  -32.571 1.000 45.332  0 415 HOH B O   1 ? 
HETATM 3010 O  O   . HOH K 6 .   ? 3.809   37.796  -8.044  1.000 50.564  0 416 HOH B O   1 ? 
HETATM 3011 O  O   . HOH K 6 .   ? 13.155  10.484  -8.948  1.000 30.490  0 417 HOH B O   1 ? 
HETATM 3012 O  O   . HOH K 6 .   ? 1.890   22.589  -29.381 1.000 33.532  0 418 HOH B O   1 ? 
HETATM 3013 O  O   . HOH K 6 .   ? -1.383  5.750   -20.281 1.000 44.824  0 419 HOH B O   1 ? 
HETATM 3014 O  O   . HOH K 6 .   ? 20.405  12.140  -9.539  1.000 40.423  0 420 HOH B O   1 ? 
HETATM 3015 O  O   . HOH K 6 .   ? 12.129  6.854   -7.978  1.000 30.443  0 421 HOH B O   1 ? 
HETATM 3016 O  O   . HOH K 6 .   ? 10.236  9.249   -36.485 1.000 46.179  0 422 HOH B O   1 ? 
HETATM 3017 O  O   . HOH K 6 .   ? 30.184  35.428  -10.865 1.000 33.445  0 423 HOH B O   1 ? 
HETATM 3018 O  O   . HOH K 6 .   ? 20.296  11.103  -30.529 1.000 30.816  0 424 HOH B O   1 ? 
HETATM 3019 O  O   . HOH K 6 .   ? 9.442   31.645  -24.223 1.000 39.318  0 425 HOH B O   1 ? 
HETATM 3020 O  O   . HOH K 6 .   ? 5.959   12.530  -32.767 1.000 41.169  0 426 HOH B O   1 ? 
HETATM 3021 O  O   . HOH K 6 .   ? 1.516   28.535  -7.650  1.000 37.697  0 427 HOH B O   1 ? 
HETATM 3022 O  O   . HOH K 6 .   ? 4.221   9.009   -21.989 1.000 26.755  0 428 HOH B O   1 ? 
HETATM 3023 O  O   . HOH K 6 .   ? 12.770  11.872  -12.253 1.000 29.449  0 429 HOH B O   1 ? 
HETATM 3024 O  O   . HOH K 6 .   ? 2.835   14.221  -10.979 1.000 32.501  0 430 HOH B O   1 ? 
HETATM 3025 O  O   . HOH K 6 .   ? 23.902  30.640  -17.780 1.000 43.745  0 431 HOH B O   1 ? 
HETATM 3026 O  O   . HOH K 6 .   ? 12.701  28.592  -18.800 1.000 25.769  0 432 HOH B O   1 ? 
HETATM 3027 O  O   . HOH K 6 .   ? 3.943   34.217  -2.183  1.000 39.263  0 433 HOH B O   1 ? 
HETATM 3028 O  O   . HOH K 6 .   ? 6.787   11.339  -36.596 1.000 46.649  0 434 HOH B O   1 ? 
HETATM 3029 O  O   . HOH K 6 .   ? 14.733  14.152  -0.192  1.000 36.666  0 435 HOH B O   1 ? 
HETATM 3030 O  O   . HOH K 6 .   ? 10.144  33.177  -14.124 1.000 23.452  0 436 HOH B O   1 ? 
HETATM 3031 O  O   . HOH K 6 .   ? 10.407  39.749  -1.543  1.000 36.492  0 437 HOH B O   1 ? 
HETATM 3032 O  O   . HOH K 6 .   ? 19.952  7.549   -26.776 1.000 34.030  0 438 HOH B O   1 ? 
HETATM 3033 O  O   . HOH K 6 .   ? 27.117  21.067  -15.719 1.000 44.726  0 439 HOH B O   1 ? 
HETATM 3034 O  O   . HOH K 6 .   ? -2.612  -0.318  -29.756 1.000 47.161  0 440 HOH B O   1 ? 
HETATM 3035 O  O   . HOH K 6 .   ? 0.819   6.543   -27.471 1.000 41.401  0 441 HOH B O   1 ? 
HETATM 3036 O  O   . HOH K 6 .   ? 20.350  20.341  -28.846 1.000 29.870  0 442 HOH B O   1 ? 
HETATM 3037 O  O   . HOH K 6 .   ? 18.077  19.136  -4.272  1.000 25.389  0 443 HOH B O   1 ? 
HETATM 3038 O  O   . HOH K 6 .   ? 12.848  27.572  -31.171 1.000 33.953  0 444 HOH B O   1 ? 
HETATM 3039 O  O   . HOH K 6 .   ? 18.728  30.947  -23.060 1.000 34.779  0 445 HOH B O   1 ? 
HETATM 3040 O  O   . HOH K 6 .   ? 19.790  10.343  -13.228 1.000 48.478  0 446 HOH B O   1 ? 
HETATM 3041 O  O   . HOH K 6 .   ? 8.066   18.762  -32.891 1.000 29.942  0 447 HOH B O   1 ? 
HETATM 3042 O  O   . HOH K 6 .   ? 26.580  25.281  -11.627 1.000 49.529  0 448 HOH B O   1 ? 
HETATM 3043 O  O   . HOH K 6 .   ? 4.330   26.609  -2.747  1.000 50.253  0 449 HOH B O   1 ? 
HETATM 3044 O  O   . HOH K 6 .   ? 23.822  13.723  -15.581 1.000 45.753  0 450 HOH B O   1 ? 
HETATM 3045 O  O   . HOH K 6 .   ? 2.189   18.304  -16.645 1.000 25.287  0 451 HOH B O   1 ? 
HETATM 3046 O  O   . HOH K 6 .   ? 9.107   29.277  -1.341  1.000 36.460  0 452 HOH B O   1 ? 
HETATM 3047 O  O   . HOH K 6 .   ? 15.583  8.739   -14.679 1.000 38.589  0 453 HOH B O   1 ? 
HETATM 3048 O  O   . HOH K 6 .   ? 24.604  24.470  -17.261 1.000 42.590  0 454 HOH B O   1 ? 
HETATM 3049 O  O   . HOH K 6 .   ? 0.313   19.788  -9.667  1.000 32.908  0 455 HOH B O   1 ? 
HETATM 3050 O  O   . HOH K 6 .   ? 7.999   18.004  -2.401  1.000 26.512  0 456 HOH B O   1 ? 
HETATM 3051 O  O   . HOH K 6 .   ? 12.137  12.816  -7.791  1.000 30.139  0 457 HOH B O   1 ? 
HETATM 3052 O  O   . HOH K 6 .   ? 18.287  4.979   -27.058 1.000 39.770  0 458 HOH B O   1 ? 
HETATM 3053 O  O   . HOH K 6 .   ? 19.407  22.263  -18.094 1.000 31.877  0 459 HOH B O   1 ? 
HETATM 3054 O  O   . HOH K 6 .   ? -1.279  26.294  -26.495 1.000 47.463  0 460 HOH B O   1 ? 
HETATM 3055 O  O   . HOH K 6 .   ? 16.849  18.920  -1.826  1.000 29.142  0 461 HOH B O   1 ? 
HETATM 3056 O  O   . HOH K 6 .   ? 9.237   29.124  -30.627 1.000 46.807  0 462 HOH B O   1 ? 
HETATM 3057 O  O   . HOH K 6 .   ? 6.845   31.778  -26.136 1.000 34.189  0 463 HOH B O   1 ? 
HETATM 3058 O  O   . HOH K 6 .   ? -2.053  11.907  -15.306 1.000 38.610  0 464 HOH B O   1 ? 
HETATM 3059 O  O   . HOH K 6 .   ? 4.837   28.251  -19.990 1.000 29.937  0 465 HOH B O   1 ? 
HETATM 3060 O  O   . HOH K 6 .   ? 2.718   3.637   -15.515 1.000 47.023  0 466 HOH B O   1 ? 
HETATM 3061 O  O   . HOH K 6 .   ? 22.937  19.888  -6.828  1.000 33.534  0 467 HOH B O   1 ? 
HETATM 3062 O  O   . HOH K 6 .   ? 8.669   35.358  -11.237 1.000 42.231  0 468 HOH B O   1 ? 
HETATM 3063 O  O   . HOH K 6 .   ? 18.763  16.633  -5.220  1.000 27.053  0 469 HOH B O   1 ? 
HETATM 3064 O  O   . HOH K 6 .   ? 6.214   2.255   -22.775 1.000 37.740  0 470 HOH B O   1 ? 
HETATM 3065 O  O   . HOH K 6 .   ? 18.649  40.340  -7.514  1.000 36.735  0 471 HOH B O   1 ? 
HETATM 3066 O  O   . HOH K 6 .   ? 7.238   33.450  -14.403 1.000 31.010  0 472 HOH B O   1 ? 
HETATM 3067 O  O   . HOH K 6 .   ? 3.549   12.055  -31.163 1.000 34.616  0 473 HOH B O   1 ? 
HETATM 3068 O  O   . HOH K 6 .   ? 29.087  30.412  -6.963  1.000 28.217  0 474 HOH B O   1 ? 
HETATM 3069 O  O   . HOH K 6 .   ? 4.597   19.026  -17.801 1.000 22.325  0 475 HOH B O   1 ? 
HETATM 3070 O  O   . HOH K 6 .   ? 19.803  28.102  -15.074 1.000 24.844  0 476 HOH B O   1 ? 
HETATM 3071 O  O   . HOH K 6 .   ? 20.877  20.044  -4.273  1.000 29.585  0 477 HOH B O   1 ? 
HETATM 3072 O  O   . HOH K 6 .   ? 0.204   15.904  -27.228 1.000 40.694  0 478 HOH B O   1 ? 
HETATM 3073 O  O   . HOH K 6 .   ? 21.117  25.340  -25.837 1.000 39.201  0 479 HOH B O   1 ? 
HETATM 3074 O  O   . HOH K 6 .   ? 0.985   9.128   -27.287 1.000 36.102  0 480 HOH B O   1 ? 
HETATM 3075 O  O   . HOH K 6 .   ? -3.008  9.004   -22.000 1.000 41.028  0 481 HOH B O   1 ? 
HETATM 3076 O  O   . HOH K 6 .   ? 15.659  9.654   -20.893 1.000 24.329  0 482 HOH B O   1 ? 
HETATM 3077 O  O   . HOH K 6 .   ? 21.081  36.355  -15.202 1.000 30.693  0 483 HOH B O   1 ? 
HETATM 3078 O  O   . HOH K 6 .   ? 20.330  16.801  -30.253 1.000 29.291  0 484 HOH B O   1 ? 
HETATM 3079 O  O   . HOH K 6 .   ? 14.799  28.279  0.492   1.000 41.007  0 485 HOH B O   1 ? 
HETATM 3080 O  O   . HOH K 6 .   ? -1.910  18.975  -10.567 1.000 43.510  0 486 HOH B O   1 ? 
HETATM 3081 O  O   . HOH K 6 .   ? 23.691  15.564  -33.141 1.000 48.466  0 487 HOH B O   1 ? 
HETATM 3082 O  O   . HOH K 6 .   ? 11.857  31.880  -1.265  1.000 33.199  0 488 HOH B O   1 ? 
HETATM 3083 O  O   . HOH K 6 .   ? 4.435   8.399   -25.993 1.000 40.360  0 489 HOH B O   1 ? 
HETATM 3084 O  O   . HOH K 6 .   ? 2.804   18.514  -5.725  1.000 31.579  0 490 HOH B O   1 ? 
HETATM 3085 O  O   . HOH K 6 .   ? 3.889   15.716  -15.993 1.000 23.593  0 491 HOH B O   1 ? 
HETATM 3086 O  O   . HOH K 6 .   ? 20.877  37.769  -8.552  1.000 26.984  0 492 HOH B O   1 ? 
HETATM 3087 O  O   . HOH K 6 .   ? 2.847   15.402  -8.451  1.000 28.480  0 493 HOH B O   1 ? 
HETATM 3088 O  O   . HOH K 6 .   ? 23.492  22.088  -16.693 1.000 30.971  0 494 HOH B O   1 ? 
HETATM 3089 O  O   . HOH K 6 .   ? 27.351  27.676  -12.221 1.000 38.305  0 495 HOH B O   1 ? 
HETATM 3090 O  O   . HOH K 6 .   ? 13.741  14.343  -36.484 1.000 28.579  0 496 HOH B O   1 ? 
HETATM 3091 O  O   . HOH K 6 .   ? 18.991  13.583  -6.716  1.000 42.438  0 497 HOH B O   1 ? 
HETATM 3092 O  O   . HOH K 6 .   ? 10.109  2.929   -26.101 1.000 40.146  0 498 HOH B O   1 ? 
HETATM 3093 O  O   . HOH K 6 .   ? 11.841  21.962  0.934   1.000 42.960  0 499 HOH B O   1 ? 
HETATM 3094 O  O   . HOH K 6 .   ? 22.783  18.159  -10.778 1.000 26.725  0 500 HOH B O   1 ? 
HETATM 3095 O  O   . HOH K 6 .   ? 15.593  34.762  -0.362  1.000 33.782  0 501 HOH B O   1 ? 
HETATM 3096 O  O   . HOH K 6 .   ? 3.584   43.160  -4.274  1.000 40.971  0 502 HOH B O   1 ? 
HETATM 3097 O  O   . HOH K 6 .   ? 15.713  5.198   -20.414 1.000 43.567  0 503 HOH B O   1 ? 
HETATM 3098 O  O   . HOH K 6 .   ? 3.491   7.263   -33.648 1.000 51.150  0 504 HOH B O   1 ? 
HETATM 3099 O  O   . HOH K 6 .   ? 23.349  27.546  -1.015  1.000 33.594  0 505 HOH B O   1 ? 
HETATM 3100 O  O   . HOH K 6 .   ? 5.992   22.325  -1.177  1.000 43.676  0 506 HOH B O   1 ? 
HETATM 3101 O  O   . HOH K 6 .   ? 2.780   29.484  -32.104 1.000 38.175  0 507 HOH B O   1 ? 
HETATM 3102 O  O   . HOH K 6 .   ? 21.283  30.219  -14.549 1.000 26.882  0 508 HOH B O   1 ? 
HETATM 3103 O  O   . HOH K 6 .   ? 12.035  9.122   -15.141 1.000 32.580  0 509 HOH B O   1 ? 
HETATM 3104 O  O   . HOH K 6 .   ? 22.418  27.681  -21.767 1.000 28.319  0 510 HOH B O   1 ? 
HETATM 3105 O  O   . HOH K 6 .   ? 11.281  11.751  -14.605 1.000 24.785  0 511 HOH B O   1 ? 
HETATM 3106 O  O   . HOH K 6 .   ? 23.741  9.812   -18.497 1.000 46.701  0 512 HOH B O   1 ? 
HETATM 3107 O  O   . HOH K 6 .   ? 8.743   21.923  -35.378 1.000 45.672  0 513 HOH B O   1 ? 
HETATM 3108 O  O   . HOH K 6 .   ? 24.668  12.927  -22.189 1.000 32.398  0 514 HOH B O   1 ? 
HETATM 3109 O  O   . HOH K 6 .   ? 9.049   23.240  -0.091  1.000 33.433  0 515 HOH B O   1 ? 
HETATM 3110 O  O   . HOH K 6 .   ? 4.133   20.619  -4.461  1.000 24.025  0 516 HOH B O   1 ? 
HETATM 3111 O  O   . HOH K 6 .   ? 14.832  40.271  -15.693 1.000 46.830  0 517 HOH B O   1 ? 
HETATM 3112 O  O   . HOH K 6 .   ? 12.722  28.948  1.930   1.000 44.850  0 518 HOH B O   1 ? 
HETATM 3113 O  O   . HOH K 6 .   ? -0.879  4.406   -24.325 1.000 52.547  0 519 HOH B O   1 ? 
HETATM 3114 O  O   . HOH K 6 .   ? 7.732   16.047  -37.869 1.000 48.241  0 520 HOH B O   1 ? 
HETATM 3115 O  O   . HOH K 6 .   ? 8.181   11.838  -4.687  1.000 38.007  0 521 HOH B O   1 ? 
HETATM 3116 O  O   . HOH K 6 .   ? 4.549   13.761  -7.053  1.000 31.536  0 522 HOH B O   1 ? 
HETATM 3117 O  O   . HOH K 6 .   ? 18.375  6.889   -18.978 1.000 39.686  0 523 HOH B O   1 ? 
HETATM 3118 O  O   . HOH K 6 .   ? -4.191  21.659  -17.263 1.000 45.039  0 524 HOH B O   1 ? 
HETATM 3119 O  O   . HOH K 6 .   ? 11.321  13.330  -16.839 1.000 23.623  0 525 HOH B O   1 ? 
HETATM 3120 O  O   . HOH K 6 .   ? 16.177  14.167  -35.324 1.000 36.905  0 526 HOH B O   1 ? 
HETATM 3121 O  O   . HOH K 6 .   ? 25.480  34.441  -11.837 1.000 49.156  0 527 HOH B O   1 ? 
HETATM 3122 O  O   . HOH K 6 .   ? 23.640  26.323  -13.535 1.000 36.940  0 528 HOH B O   1 ? 
HETATM 3123 O  O   . HOH K 6 .   ? 5.224   18.441  -15.187 1.000 22.764  0 529 HOH B O   1 ? 
HETATM 3124 O  O   . HOH K 6 .   ? 11.804  39.652  -15.738 1.000 46.314  0 530 HOH B O   1 ? 
HETATM 3125 O  O   . HOH K 6 .   ? 21.437  25.832  -15.330 1.000 25.093  0 531 HOH B O   1 ? 
HETATM 3126 O  O   . HOH K 6 .   ? 20.806  22.127  -26.728 1.000 32.031  0 532 HOH B O   1 ? 
HETATM 3127 O  O   . HOH K 6 .   ? 6.238   6.752   -13.584 1.000 44.368  0 533 HOH B O   1 ? 
HETATM 3128 O  O   . HOH K 6 .   ? 26.719  24.986  -0.113  1.000 45.776  0 534 HOH B O   1 ? 
HETATM 3129 O  O   . HOH K 6 .   ? -12.437 12.820  -18.739 1.000 65.195  0 535 HOH B O   1 ? 
HETATM 3130 O  O   . HOH K 6 .   ? 7.283   0.408   -16.056 1.000 53.883  0 536 HOH B O   1 ? 
HETATM 3131 O  O   . HOH K 6 .   ? -1.072  24.922  -10.864 1.000 47.062  0 537 HOH B O   1 ? 
HETATM 3132 O  O   . HOH K 6 .   ? 15.091  24.283  1.734   1.000 54.327  0 538 HOH B O   1 ? 
HETATM 3133 O  O   . HOH K 6 .   ? 16.487  30.324  0.393   1.000 40.823  0 539 HOH B O   1 ? 
HETATM 3134 O  O   . HOH K 6 .   ? 13.318  23.681  -37.145 1.000 49.666  0 540 HOH B O   1 ? 
HETATM 3135 O  O   . HOH K 6 .   ? 21.480  11.937  -14.903 1.000 50.542  0 541 HOH B O   1 ? 
HETATM 3136 O  O   . HOH K 6 .   ? -3.706  29.356  -18.849 1.000 55.700  0 542 HOH B O   1 ? 
HETATM 3137 O  O   . HOH K 6 .   ? 23.478  28.672  -14.843 1.000 42.080  0 543 HOH B O   1 ? 
HETATM 3138 O  O   . HOH K 6 .   ? 6.723   26.683  -1.852  1.000 50.758  0 544 HOH B O   1 ? 
HETATM 3139 O  O   . HOH K 6 .   ? 6.826   18.290  -35.300 1.000 45.700  0 545 HOH B O   1 ? 
HETATM 3140 O  O   . HOH K 6 .   ? 22.634  34.233  -15.144 1.000 33.383  0 546 HOH B O   1 ? 
HETATM 3141 O  O   . HOH K 6 .   ? 2.522   22.453  -3.504  1.000 36.268  0 547 HOH B O   1 ? 
HETATM 3142 O  O   . HOH K 6 .   ? 19.427  8.458   -7.991  1.000 48.083  0 548 HOH B O   1 ? 
HETATM 3143 O  O   . HOH K 6 .   ? 11.783  13.988  0.399   1.000 44.378  0 549 HOH B O   1 ? 
HETATM 3144 O  O   . HOH K 6 .   ? 22.315  6.512   -26.421 1.000 45.181  0 550 HOH B O   1 ? 
HETATM 3145 O  O   . HOH K 6 .   ? 7.709   13.540  -0.658  1.000 50.832  0 551 HOH B O   1 ? 
HETATM 3146 O  O   . HOH K 6 .   ? 22.625  17.755  -8.209  1.000 32.320  0 552 HOH B O   1 ? 
HETATM 3147 O  O   . HOH K 6 .   ? 17.989  7.475   -37.053 1.000 60.847  0 553 HOH B O   1 ? 
HETATM 3148 O  O   . HOH K 6 .   ? 22.401  14.890  -29.612 1.000 38.302  0 554 HOH B O   1 ? 
HETATM 3149 O  O   . HOH K 6 .   ? 24.457  20.644  -18.894 1.000 46.215  0 555 HOH B O   1 ? 
HETATM 3150 O  O   . HOH K 6 .   ? -1.895  11.313  -12.503 1.000 49.491  0 556 HOH B O   1 ? 
HETATM 3151 O  O   . HOH K 6 .   ? 11.973  27.731  -33.692 1.000 53.036  0 557 HOH B O   1 ? 
HETATM 3152 O  O   . HOH K 6 .   ? 22.125  31.814  -16.494 1.000 31.832  0 558 HOH B O   1 ? 
HETATM 3153 O  O   . HOH K 6 .   ? 0.306   19.076  -6.794  1.000 44.824  0 559 HOH B O   1 ? 
HETATM 3154 O  O   . HOH K 6 .   ? 5.717   19.384  -2.495  1.000 30.100  0 560 HOH B O   1 ? 
HETATM 3155 O  O   . HOH K 6 .   ? 19.125  3.889   -19.947 1.000 48.941  0 561 HOH B O   1 ? 
HETATM 3156 O  O   . HOH K 6 .   ? 22.078  17.963  -32.040 1.000 34.402  0 562 HOH B O   1 ? 
HETATM 3157 O  O   . HOH K 6 .   ? 7.265   6.998   -7.768  1.000 48.075  0 563 HOH B O   1 ? 
HETATM 3158 O  O   . HOH K 6 .   ? 25.505  14.198  -19.786 1.000 43.787  0 564 HOH B O   1 ? 
HETATM 3159 O  O   . HOH K 6 .   ? 21.078  10.625  -11.315 1.000 49.834  0 565 HOH B O   1 ? 
HETATM 3160 O  O   . HOH K 6 .   ? 20.507  32.448  -18.520 1.000 50.658  0 566 HOH B O   1 ? 
HETATM 3161 O  O   . HOH K 6 .   ? 3.001   16.454  -3.928  1.000 43.897  0 567 HOH B O   1 ? 
HETATM 3162 O  O   . HOH K 6 .   ? 4.843   4.360   -14.016 1.000 41.641  0 568 HOH B O   1 ? 
HETATM 3163 O  O   . HOH K 6 .   ? 25.658  24.855  -14.769 1.000 41.177  0 569 HOH B O   1 ? 
HETATM 3164 O  O   . HOH K 6 .   ? 1.678   23.132  -31.808 1.000 50.500  0 570 HOH B O   1 ? 
HETATM 3165 O  O   . HOH K 6 .   ? 4.834   14.687  -4.536  1.000 39.130  0 571 HOH B O   1 ? 
HETATM 3166 O  O   . HOH K 6 .   ? 0.367   15.114  -7.225  1.000 42.242  0 572 HOH B O   1 ? 
HETATM 3167 O  O   . HOH K 6 .   ? 24.596  37.941  -14.059 1.000 56.016  0 573 HOH B O   1 ? 
HETATM 3168 O  O   . HOH K 6 .   ? 25.100  35.493  -14.152 1.000 49.405  0 574 HOH B O   1 ? 
# 
