data_8S6B
# 
_entry.id   8S6B 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8S6B         pdb_00008s6b 10.2210/pdb8s6b/pdb 
WWPDB D_1292136895 ?            ?                   
EMDB  EMD-19757    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2025-02-26 ? 
2  'EM metadata'     1 0 2025-02-26 ? 
3  'Additional map'  1 0 2025-02-26 1 
4  FSC               1 0 2025-02-26 ? 
5  'Half map'        1 0 2025-02-26 1 
6  'Half map'        1 0 2025-02-26 2 
7  Image             1 0 2025-02-26 ? 
8  Mask              1 0 2025-02-26 1 
9  'Primary map'     1 0 2025-02-26 ? 
10 'Structure model' 1 1 2025-03-05 ? 
11 'EM metadata'     1 1 2025-03-05 ? 
12 'Structure model' 1 2 2025-03-12 ? 
13 'EM metadata'     1 2 2025-03-12 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 FSC               repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 Image             repository 'Initial release' ? ? 
8 8 Mask              repository 'Initial release' ? ? 
9 9 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 10 'Structure model' 'Data collection'      
2 10 'Structure model' 'Database references'  
3 11 'EM metadata'     'Database references'  
4 11 'EM metadata'     'Experimental summary' 
5 12 'Structure model' 'Data collection'      
6 12 'Structure model' 'Database references'  
7 13 'EM metadata'     'Database references'  
8 13 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1  10 'Structure model' citation        
2  10 'Structure model' citation_author 
3  10 'Structure model' em_admin        
4  11 'EM metadata'     citation        
5  11 'EM metadata'     citation_author 
6  11 'EM metadata'     em_admin        
7  12 'Structure model' citation        
8  12 'Structure model' em_admin        
9  13 'EM metadata'     citation        
10 13 'EM metadata'     em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  10 'Structure model' '_citation.country'                 
2  10 'Structure model' '_citation.journal_abbrev'          
3  10 'Structure model' '_citation.journal_id_ASTM'         
4  10 'Structure model' '_citation.journal_id_CSD'          
5  10 'Structure model' '_citation.journal_id_ISSN'         
6  10 'Structure model' '_citation.pdbx_database_id_DOI'    
7  10 'Structure model' '_citation.pdbx_database_id_PubMed' 
8  10 'Structure model' '_citation.title'                   
9  10 'Structure model' '_citation.year'                    
10 10 'Structure model' '_citation_author.identifier_ORCID' 
11 10 'Structure model' '_citation_author.name'             
12 10 'Structure model' '_em_admin.last_update'             
13 11 'EM metadata'     '_citation.country'                 
14 11 'EM metadata'     '_citation.journal_abbrev'          
15 11 'EM metadata'     '_citation.journal_id_ASTM'         
16 11 'EM metadata'     '_citation.journal_id_CSD'          
17 11 'EM metadata'     '_citation.journal_id_ISSN'         
18 11 'EM metadata'     '_citation.pdbx_database_id_DOI'    
19 11 'EM metadata'     '_citation.pdbx_database_id_PubMed' 
20 11 'EM metadata'     '_citation.title'                   
21 11 'EM metadata'     '_citation.year'                    
22 11 'EM metadata'     '_citation_author.identifier_ORCID' 
23 11 'EM metadata'     '_citation_author.name'             
24 11 'EM metadata'     '_em_admin.last_update'             
25 12 'Structure model' '_citation.journal_volume'          
26 12 'Structure model' '_citation.page_first'              
27 12 'Structure model' '_citation.page_last'               
28 12 'Structure model' '_em_admin.last_update'             
29 13 'EM metadata'     '_citation.journal_volume'          
30 13 'EM metadata'     '_citation.page_first'              
31 13 'EM metadata'     '_citation.page_last'               
32 13 'EM metadata'     '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8S6B 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB 'the same enzyme with ligand'                                               EMD-17748 'other EM volume'      
PDB  'contains the model of the same enzyme with ligand derived from EMDB-17748' 8PKN      unspecified            
EMDB 'CryoEM structure of catalytic domain of human HMG-CoA reductase'           EMD-19757 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jason.van-rooyen@diamond.ac.uk 
_pdbx_contact_author.name_first         Jason 
_pdbx_contact_author.name_last          'van Rooyen' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9485-8494 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Manikandan, K.' 1 0000-0001-5029-7816 
'Van Rooyen, J.' 2 0000-0001-9485-8494 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? US ? ? primary 'Acta Crystallogr.,Sect.F' ACSFEN ?    2053-230X ? ? 81 ? 118 122 
'Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.' 2025 ? 
10.1107/S2053230X25001098 39976191 ? ? 
? ? ? ? ? ? ? US ? ? 1       Science                    SCIEAS 0353 1095-9203 ? ? ?  ? ?   ?   
'Structural mechanism for statin inhibition of HMG-CoA reductase.'                                        2001 ? 
10.1126/science.1059344   11349148 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Karuppasamy, M.' 1 ? 
primary 'van Rooyen, J.'  2 ? 
1       'Istvan, E.S.'    3 ? 
1       'Deisenhofer, J.' 4 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           '3-hydroxy-3-methylglutaryl-coenzyme A reductase' 
_entity.formula_weight             45259.016 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    1.1.1.34 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'HMG-CoA reductase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;PREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYN
YSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEM
QILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVT
AIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL
ARIVCGTVMAGELSLMAALAAGH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;PREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYN
YSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEM
QILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVT
AIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL
ARIVCGTVMAGELSLMAALAAGH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   ARG n 
1 3   GLU n 
1 4   PRO n 
1 5   ARG n 
1 6   PRO n 
1 7   ASN n 
1 8   GLU n 
1 9   GLU n 
1 10  CYS n 
1 11  LEU n 
1 12  GLN n 
1 13  ILE n 
1 14  LEU n 
1 15  GLY n 
1 16  ASN n 
1 17  ALA n 
1 18  GLU n 
1 19  LYS n 
1 20  GLY n 
1 21  ALA n 
1 22  LYS n 
1 23  PHE n 
1 24  LEU n 
1 25  SER n 
1 26  ASP n 
1 27  ALA n 
1 28  GLU n 
1 29  ILE n 
1 30  ILE n 
1 31  GLN n 
1 32  LEU n 
1 33  VAL n 
1 34  ASN n 
1 35  ALA n 
1 36  LYS n 
1 37  HIS n 
1 38  ILE n 
1 39  PRO n 
1 40  ALA n 
1 41  TYR n 
1 42  LYS n 
1 43  LEU n 
1 44  GLU n 
1 45  THR n 
1 46  LEU n 
1 47  MET n 
1 48  GLU n 
1 49  THR n 
1 50  HIS n 
1 51  GLU n 
1 52  ARG n 
1 53  GLY n 
1 54  VAL n 
1 55  SER n 
1 56  ILE n 
1 57  ARG n 
1 58  ARG n 
1 59  GLN n 
1 60  LEU n 
1 61  LEU n 
1 62  SER n 
1 63  LYS n 
1 64  LYS n 
1 65  LEU n 
1 66  SER n 
1 67  GLU n 
1 68  PRO n 
1 69  SER n 
1 70  SER n 
1 71  LEU n 
1 72  GLN n 
1 73  TYR n 
1 74  LEU n 
1 75  PRO n 
1 76  TYR n 
1 77  ARG n 
1 78  ASP n 
1 79  TYR n 
1 80  ASN n 
1 81  TYR n 
1 82  SER n 
1 83  LEU n 
1 84  VAL n 
1 85  MET n 
1 86  GLY n 
1 87  ALA n 
1 88  CYS n 
1 89  CYS n 
1 90  GLU n 
1 91  ASN n 
1 92  VAL n 
1 93  ILE n 
1 94  GLY n 
1 95  TYR n 
1 96  MET n 
1 97  PRO n 
1 98  ILE n 
1 99  PRO n 
1 100 VAL n 
1 101 GLY n 
1 102 VAL n 
1 103 ALA n 
1 104 GLY n 
1 105 PRO n 
1 106 LEU n 
1 107 CYS n 
1 108 LEU n 
1 109 ASP n 
1 110 GLU n 
1 111 LYS n 
1 112 GLU n 
1 113 PHE n 
1 114 GLN n 
1 115 VAL n 
1 116 PRO n 
1 117 MET n 
1 118 ALA n 
1 119 THR n 
1 120 THR n 
1 121 GLU n 
1 122 GLY n 
1 123 CYS n 
1 124 LEU n 
1 125 VAL n 
1 126 ALA n 
1 127 SER n 
1 128 THR n 
1 129 ASN n 
1 130 ARG n 
1 131 GLY n 
1 132 CYS n 
1 133 ARG n 
1 134 ALA n 
1 135 ILE n 
1 136 GLY n 
1 137 LEU n 
1 138 GLY n 
1 139 GLY n 
1 140 GLY n 
1 141 ALA n 
1 142 SER n 
1 143 SER n 
1 144 ARG n 
1 145 VAL n 
1 146 LEU n 
1 147 ALA n 
1 148 ASP n 
1 149 GLY n 
1 150 MET n 
1 151 THR n 
1 152 ARG n 
1 153 GLY n 
1 154 PRO n 
1 155 VAL n 
1 156 VAL n 
1 157 ARG n 
1 158 LEU n 
1 159 PRO n 
1 160 ARG n 
1 161 ALA n 
1 162 CYS n 
1 163 ASP n 
1 164 SER n 
1 165 ALA n 
1 166 GLU n 
1 167 VAL n 
1 168 LYS n 
1 169 ALA n 
1 170 TRP n 
1 171 LEU n 
1 172 GLU n 
1 173 THR n 
1 174 SER n 
1 175 GLU n 
1 176 GLY n 
1 177 PHE n 
1 178 ALA n 
1 179 VAL n 
1 180 ILE n 
1 181 LYS n 
1 182 GLU n 
1 183 ALA n 
1 184 PHE n 
1 185 ASP n 
1 186 SER n 
1 187 THR n 
1 188 SER n 
1 189 ARG n 
1 190 PHE n 
1 191 ALA n 
1 192 ARG n 
1 193 LEU n 
1 194 GLN n 
1 195 LYS n 
1 196 LEU n 
1 197 HIS n 
1 198 THR n 
1 199 SER n 
1 200 ILE n 
1 201 ALA n 
1 202 GLY n 
1 203 ARG n 
1 204 ASN n 
1 205 LEU n 
1 206 TYR n 
1 207 ILE n 
1 208 ARG n 
1 209 PHE n 
1 210 GLN n 
1 211 SER n 
1 212 ARG n 
1 213 SER n 
1 214 GLY n 
1 215 ASP n 
1 216 ALA n 
1 217 MET n 
1 218 GLY n 
1 219 MET n 
1 220 ASN n 
1 221 MET n 
1 222 ILE n 
1 223 SER n 
1 224 LYS n 
1 225 GLY n 
1 226 THR n 
1 227 GLU n 
1 228 LYS n 
1 229 ALA n 
1 230 LEU n 
1 231 SER n 
1 232 LYS n 
1 233 LEU n 
1 234 HIS n 
1 235 GLU n 
1 236 TYR n 
1 237 PHE n 
1 238 PRO n 
1 239 GLU n 
1 240 MET n 
1 241 GLN n 
1 242 ILE n 
1 243 LEU n 
1 244 ALA n 
1 245 VAL n 
1 246 SER n 
1 247 GLY n 
1 248 ASN n 
1 249 TYR n 
1 250 CYS n 
1 251 THR n 
1 252 ASP n 
1 253 LYS n 
1 254 LYS n 
1 255 PRO n 
1 256 ALA n 
1 257 ALA n 
1 258 ILE n 
1 259 ASN n 
1 260 TRP n 
1 261 ILE n 
1 262 GLU n 
1 263 GLY n 
1 264 ARG n 
1 265 GLY n 
1 266 LYS n 
1 267 SER n 
1 268 VAL n 
1 269 VAL n 
1 270 CYS n 
1 271 GLU n 
1 272 ALA n 
1 273 VAL n 
1 274 ILE n 
1 275 PRO n 
1 276 ALA n 
1 277 LYS n 
1 278 VAL n 
1 279 VAL n 
1 280 ARG n 
1 281 GLU n 
1 282 VAL n 
1 283 LEU n 
1 284 LYS n 
1 285 THR n 
1 286 THR n 
1 287 THR n 
1 288 GLU n 
1 289 ALA n 
1 290 MET n 
1 291 ILE n 
1 292 GLU n 
1 293 VAL n 
1 294 ASN n 
1 295 ILE n 
1 296 ASN n 
1 297 LYS n 
1 298 ASN n 
1 299 LEU n 
1 300 VAL n 
1 301 GLY n 
1 302 SER n 
1 303 ALA n 
1 304 MET n 
1 305 ALA n 
1 306 GLY n 
1 307 SER n 
1 308 ILE n 
1 309 GLY n 
1 310 GLY n 
1 311 TYR n 
1 312 ASN n 
1 313 ALA n 
1 314 HIS n 
1 315 ALA n 
1 316 ALA n 
1 317 ASN n 
1 318 ILE n 
1 319 VAL n 
1 320 THR n 
1 321 ALA n 
1 322 ILE n 
1 323 TYR n 
1 324 ILE n 
1 325 ALA n 
1 326 CYS n 
1 327 GLY n 
1 328 GLN n 
1 329 ASP n 
1 330 ALA n 
1 331 ALA n 
1 332 GLN n 
1 333 ASN n 
1 334 VAL n 
1 335 GLY n 
1 336 SER n 
1 337 SER n 
1 338 ASN n 
1 339 CYS n 
1 340 ILE n 
1 341 THR n 
1 342 LEU n 
1 343 MET n 
1 344 GLU n 
1 345 ALA n 
1 346 SER n 
1 347 GLY n 
1 348 PRO n 
1 349 THR n 
1 350 ASN n 
1 351 GLU n 
1 352 ASP n 
1 353 LEU n 
1 354 TYR n 
1 355 ILE n 
1 356 SER n 
1 357 CYS n 
1 358 THR n 
1 359 MET n 
1 360 PRO n 
1 361 SER n 
1 362 ILE n 
1 363 GLU n 
1 364 ILE n 
1 365 GLY n 
1 366 THR n 
1 367 VAL n 
1 368 GLY n 
1 369 GLY n 
1 370 GLY n 
1 371 THR n 
1 372 ASN n 
1 373 LEU n 
1 374 LEU n 
1 375 PRO n 
1 376 GLN n 
1 377 GLN n 
1 378 ALA n 
1 379 CYS n 
1 380 LEU n 
1 381 GLN n 
1 382 MET n 
1 383 LEU n 
1 384 GLY n 
1 385 VAL n 
1 386 GLN n 
1 387 GLY n 
1 388 ALA n 
1 389 CYS n 
1 390 LYS n 
1 391 ASP n 
1 392 ASN n 
1 393 PRO n 
1 394 GLY n 
1 395 GLU n 
1 396 ASN n 
1 397 ALA n 
1 398 ARG n 
1 399 GLN n 
1 400 LEU n 
1 401 ALA n 
1 402 ARG n 
1 403 ILE n 
1 404 VAL n 
1 405 CYS n 
1 406 GLY n 
1 407 THR n 
1 408 VAL n 
1 409 MET n 
1 410 ALA n 
1 411 GLY n 
1 412 GLU n 
1 413 LEU n 
1 414 SER n 
1 415 LEU n 
1 416 MET n 
1 417 ALA n 
1 418 ALA n 
1 419 LEU n 
1 420 ALA n 
1 421 ALA n 
1 422 GLY n 
1 423 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   423 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 HMGCR 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   439 439 PRO PRO A . n 
A 1 2   ARG 2   440 440 ARG ARG A . n 
A 1 3   GLU 3   441 441 GLU GLU A . n 
A 1 4   PRO 4   442 442 PRO PRO A . n 
A 1 5   ARG 5   443 443 ARG ARG A . n 
A 1 6   PRO 6   444 444 PRO PRO A . n 
A 1 7   ASN 7   445 445 ASN ASN A . n 
A 1 8   GLU 8   446 446 GLU GLU A . n 
A 1 9   GLU 9   447 447 GLU GLU A . n 
A 1 10  CYS 10  448 448 CYS CYS A . n 
A 1 11  LEU 11  449 449 LEU LEU A . n 
A 1 12  GLN 12  450 450 GLN GLN A . n 
A 1 13  ILE 13  451 451 ILE ILE A . n 
A 1 14  LEU 14  452 452 LEU LEU A . n 
A 1 15  GLY 15  453 453 GLY GLY A . n 
A 1 16  ASN 16  454 454 ASN ASN A . n 
A 1 17  ALA 17  455 455 ALA ALA A . n 
A 1 18  GLU 18  456 456 GLU GLU A . n 
A 1 19  LYS 19  457 457 LYS LYS A . n 
A 1 20  GLY 20  458 458 GLY GLY A . n 
A 1 21  ALA 21  459 459 ALA ALA A . n 
A 1 22  LYS 22  460 460 LYS LYS A . n 
A 1 23  PHE 23  461 461 PHE PHE A . n 
A 1 24  LEU 24  462 462 LEU LEU A . n 
A 1 25  SER 25  463 463 SER SER A . n 
A 1 26  ASP 26  464 464 ASP ASP A . n 
A 1 27  ALA 27  465 465 ALA ALA A . n 
A 1 28  GLU 28  466 466 GLU GLU A . n 
A 1 29  ILE 29  467 467 ILE ILE A . n 
A 1 30  ILE 30  468 468 ILE ILE A . n 
A 1 31  GLN 31  469 469 GLN GLN A . n 
A 1 32  LEU 32  470 470 LEU LEU A . n 
A 1 33  VAL 33  471 471 VAL VAL A . n 
A 1 34  ASN 34  472 472 ASN ASN A . n 
A 1 35  ALA 35  473 473 ALA ALA A . n 
A 1 36  LYS 36  474 474 LYS LYS A . n 
A 1 37  HIS 37  475 475 HIS HIS A . n 
A 1 38  ILE 38  476 476 ILE ILE A . n 
A 1 39  PRO 39  477 477 PRO PRO A . n 
A 1 40  ALA 40  478 478 ALA ALA A . n 
A 1 41  TYR 41  479 479 TYR TYR A . n 
A 1 42  LYS 42  480 480 LYS LYS A . n 
A 1 43  LEU 43  481 481 LEU LEU A . n 
A 1 44  GLU 44  482 482 GLU GLU A . n 
A 1 45  THR 45  483 483 THR THR A . n 
A 1 46  LEU 46  484 484 LEU LEU A . n 
A 1 47  MET 47  485 485 MET MET A . n 
A 1 48  GLU 48  486 486 GLU GLU A . n 
A 1 49  THR 49  487 487 THR THR A . n 
A 1 50  HIS 50  488 488 HIS HIS A . n 
A 1 51  GLU 51  489 489 GLU GLU A . n 
A 1 52  ARG 52  490 490 ARG ARG A . n 
A 1 53  GLY 53  491 491 GLY GLY A . n 
A 1 54  VAL 54  492 492 VAL VAL A . n 
A 1 55  SER 55  493 493 SER SER A . n 
A 1 56  ILE 56  494 494 ILE ILE A . n 
A 1 57  ARG 57  495 495 ARG ARG A . n 
A 1 58  ARG 58  496 496 ARG ARG A . n 
A 1 59  GLN 59  497 497 GLN GLN A . n 
A 1 60  LEU 60  498 498 LEU LEU A . n 
A 1 61  LEU 61  499 499 LEU LEU A . n 
A 1 62  SER 62  500 500 SER SER A . n 
A 1 63  LYS 63  501 501 LYS LYS A . n 
A 1 64  LYS 64  502 502 LYS LYS A . n 
A 1 65  LEU 65  503 503 LEU LEU A . n 
A 1 66  SER 66  504 504 SER SER A . n 
A 1 67  GLU 67  505 505 GLU GLU A . n 
A 1 68  PRO 68  506 506 PRO PRO A . n 
A 1 69  SER 69  507 507 SER SER A . n 
A 1 70  SER 70  508 508 SER SER A . n 
A 1 71  LEU 71  509 509 LEU LEU A . n 
A 1 72  GLN 72  510 510 GLN GLN A . n 
A 1 73  TYR 73  511 511 TYR TYR A . n 
A 1 74  LEU 74  512 512 LEU LEU A . n 
A 1 75  PRO 75  513 513 PRO PRO A . n 
A 1 76  TYR 76  514 514 TYR TYR A . n 
A 1 77  ARG 77  515 515 ARG ARG A . n 
A 1 78  ASP 78  516 516 ASP ASP A . n 
A 1 79  TYR 79  517 517 TYR TYR A . n 
A 1 80  ASN 80  518 518 ASN ASN A . n 
A 1 81  TYR 81  519 519 TYR TYR A . n 
A 1 82  SER 82  520 520 SER SER A . n 
A 1 83  LEU 83  521 521 LEU LEU A . n 
A 1 84  VAL 84  522 522 VAL VAL A . n 
A 1 85  MET 85  523 523 MET MET A . n 
A 1 86  GLY 86  524 524 GLY GLY A . n 
A 1 87  ALA 87  525 525 ALA ALA A . n 
A 1 88  CYS 88  526 526 CYS CYS A . n 
A 1 89  CYS 89  527 527 CYS CYS A . n 
A 1 90  GLU 90  528 528 GLU GLU A . n 
A 1 91  ASN 91  529 529 ASN ASN A . n 
A 1 92  VAL 92  530 530 VAL VAL A . n 
A 1 93  ILE 93  531 531 ILE ILE A . n 
A 1 94  GLY 94  532 532 GLY GLY A . n 
A 1 95  TYR 95  533 533 TYR TYR A . n 
A 1 96  MET 96  534 534 MET MET A . n 
A 1 97  PRO 97  535 535 PRO PRO A . n 
A 1 98  ILE 98  536 536 ILE ILE A . n 
A 1 99  PRO 99  537 537 PRO PRO A . n 
A 1 100 VAL 100 538 538 VAL VAL A . n 
A 1 101 GLY 101 539 539 GLY GLY A . n 
A 1 102 VAL 102 540 540 VAL VAL A . n 
A 1 103 ALA 103 541 541 ALA ALA A . n 
A 1 104 GLY 104 542 542 GLY GLY A . n 
A 1 105 PRO 105 543 543 PRO PRO A . n 
A 1 106 LEU 106 544 544 LEU LEU A . n 
A 1 107 CYS 107 545 545 CYS CYS A . n 
A 1 108 LEU 108 546 546 LEU LEU A . n 
A 1 109 ASP 109 547 547 ASP ASP A . n 
A 1 110 GLU 110 548 548 GLU GLU A . n 
A 1 111 LYS 111 549 549 LYS LYS A . n 
A 1 112 GLU 112 550 550 GLU GLU A . n 
A 1 113 PHE 113 551 551 PHE PHE A . n 
A 1 114 GLN 114 552 552 GLN GLN A . n 
A 1 115 VAL 115 553 553 VAL VAL A . n 
A 1 116 PRO 116 554 554 PRO PRO A . n 
A 1 117 MET 117 555 555 MET MET A . n 
A 1 118 ALA 118 556 556 ALA ALA A . n 
A 1 119 THR 119 557 557 THR THR A . n 
A 1 120 THR 120 558 558 THR THR A . n 
A 1 121 GLU 121 559 559 GLU GLU A . n 
A 1 122 GLY 122 560 560 GLY GLY A . n 
A 1 123 CYS 123 561 561 CYS CYS A . n 
A 1 124 LEU 124 562 562 LEU LEU A . n 
A 1 125 VAL 125 563 563 VAL VAL A . n 
A 1 126 ALA 126 564 564 ALA ALA A . n 
A 1 127 SER 127 565 565 SER SER A . n 
A 1 128 THR 128 566 566 THR THR A . n 
A 1 129 ASN 129 567 567 ASN ASN A . n 
A 1 130 ARG 130 568 568 ARG ARG A . n 
A 1 131 GLY 131 569 569 GLY GLY A . n 
A 1 132 CYS 132 570 570 CYS CYS A . n 
A 1 133 ARG 133 571 571 ARG ARG A . n 
A 1 134 ALA 134 572 572 ALA ALA A . n 
A 1 135 ILE 135 573 573 ILE ILE A . n 
A 1 136 GLY 136 574 574 GLY GLY A . n 
A 1 137 LEU 137 575 575 LEU LEU A . n 
A 1 138 GLY 138 576 576 GLY GLY A . n 
A 1 139 GLY 139 577 577 GLY GLY A . n 
A 1 140 GLY 140 578 578 GLY GLY A . n 
A 1 141 ALA 141 579 579 ALA ALA A . n 
A 1 142 SER 142 580 580 SER SER A . n 
A 1 143 SER 143 581 581 SER SER A . n 
A 1 144 ARG 144 582 582 ARG ARG A . n 
A 1 145 VAL 145 583 583 VAL VAL A . n 
A 1 146 LEU 146 584 584 LEU LEU A . n 
A 1 147 ALA 147 585 585 ALA ALA A . n 
A 1 148 ASP 148 586 586 ASP ASP A . n 
A 1 149 GLY 149 587 587 GLY GLY A . n 
A 1 150 MET 150 588 588 MET MET A . n 
A 1 151 THR 151 589 589 THR THR A . n 
A 1 152 ARG 152 590 590 ARG ARG A . n 
A 1 153 GLY 153 591 591 GLY GLY A . n 
A 1 154 PRO 154 592 592 PRO PRO A . n 
A 1 155 VAL 155 593 593 VAL VAL A . n 
A 1 156 VAL 156 594 594 VAL VAL A . n 
A 1 157 ARG 157 595 595 ARG ARG A . n 
A 1 158 LEU 158 596 596 LEU LEU A . n 
A 1 159 PRO 159 597 597 PRO PRO A . n 
A 1 160 ARG 160 598 598 ARG ARG A . n 
A 1 161 ALA 161 599 599 ALA ALA A . n 
A 1 162 CYS 162 600 600 CYS CYS A . n 
A 1 163 ASP 163 601 601 ASP ASP A . n 
A 1 164 SER 164 602 602 SER SER A . n 
A 1 165 ALA 165 603 603 ALA ALA A . n 
A 1 166 GLU 166 604 604 GLU GLU A . n 
A 1 167 VAL 167 605 605 VAL VAL A . n 
A 1 168 LYS 168 606 606 LYS LYS A . n 
A 1 169 ALA 169 607 607 ALA ALA A . n 
A 1 170 TRP 170 608 608 TRP TRP A . n 
A 1 171 LEU 171 609 609 LEU LEU A . n 
A 1 172 GLU 172 610 610 GLU GLU A . n 
A 1 173 THR 173 611 611 THR THR A . n 
A 1 174 SER 174 612 612 SER SER A . n 
A 1 175 GLU 175 613 613 GLU GLU A . n 
A 1 176 GLY 176 614 614 GLY GLY A . n 
A 1 177 PHE 177 615 615 PHE PHE A . n 
A 1 178 ALA 178 616 616 ALA ALA A . n 
A 1 179 VAL 179 617 617 VAL VAL A . n 
A 1 180 ILE 180 618 618 ILE ILE A . n 
A 1 181 LYS 181 619 619 LYS LYS A . n 
A 1 182 GLU 182 620 620 GLU GLU A . n 
A 1 183 ALA 183 621 621 ALA ALA A . n 
A 1 184 PHE 184 622 622 PHE PHE A . n 
A 1 185 ASP 185 623 623 ASP ASP A . n 
A 1 186 SER 186 624 624 SER SER A . n 
A 1 187 THR 187 625 625 THR THR A . n 
A 1 188 SER 188 626 626 SER SER A . n 
A 1 189 ARG 189 627 627 ARG ARG A . n 
A 1 190 PHE 190 628 628 PHE PHE A . n 
A 1 191 ALA 191 629 629 ALA ALA A . n 
A 1 192 ARG 192 630 630 ARG ARG A . n 
A 1 193 LEU 193 631 631 LEU LEU A . n 
A 1 194 GLN 194 632 632 GLN GLN A . n 
A 1 195 LYS 195 633 633 LYS LYS A . n 
A 1 196 LEU 196 634 634 LEU LEU A . n 
A 1 197 HIS 197 635 635 HIS HIS A . n 
A 1 198 THR 198 636 636 THR THR A . n 
A 1 199 SER 199 637 637 SER SER A . n 
A 1 200 ILE 200 638 638 ILE ILE A . n 
A 1 201 ALA 201 639 639 ALA ALA A . n 
A 1 202 GLY 202 640 640 GLY GLY A . n 
A 1 203 ARG 203 641 641 ARG ARG A . n 
A 1 204 ASN 204 642 642 ASN ASN A . n 
A 1 205 LEU 205 643 643 LEU LEU A . n 
A 1 206 TYR 206 644 644 TYR TYR A . n 
A 1 207 ILE 207 645 645 ILE ILE A . n 
A 1 208 ARG 208 646 646 ARG ARG A . n 
A 1 209 PHE 209 647 647 PHE PHE A . n 
A 1 210 GLN 210 648 648 GLN GLN A . n 
A 1 211 SER 211 649 649 SER SER A . n 
A 1 212 ARG 212 650 650 ARG ARG A . n 
A 1 213 SER 213 651 651 SER SER A . n 
A 1 214 GLY 214 652 652 GLY GLY A . n 
A 1 215 ASP 215 653 653 ASP ASP A . n 
A 1 216 ALA 216 654 654 ALA ALA A . n 
A 1 217 MET 217 655 655 MET MET A . n 
A 1 218 GLY 218 656 656 GLY GLY A . n 
A 1 219 MET 219 657 657 MET MET A . n 
A 1 220 ASN 220 658 658 ASN ASN A . n 
A 1 221 MET 221 659 659 MET MET A . n 
A 1 222 ILE 222 660 660 ILE ILE A . n 
A 1 223 SER 223 661 661 SER SER A . n 
A 1 224 LYS 224 662 662 LYS LYS A . n 
A 1 225 GLY 225 663 663 GLY GLY A . n 
A 1 226 THR 226 664 664 THR THR A . n 
A 1 227 GLU 227 665 665 GLU GLU A . n 
A 1 228 LYS 228 666 666 LYS LYS A . n 
A 1 229 ALA 229 667 667 ALA ALA A . n 
A 1 230 LEU 230 668 668 LEU LEU A . n 
A 1 231 SER 231 669 669 SER SER A . n 
A 1 232 LYS 232 670 670 LYS LYS A . n 
A 1 233 LEU 233 671 671 LEU LEU A . n 
A 1 234 HIS 234 672 672 HIS HIS A . n 
A 1 235 GLU 235 673 673 GLU GLU A . n 
A 1 236 TYR 236 674 674 TYR TYR A . n 
A 1 237 PHE 237 675 675 PHE PHE A . n 
A 1 238 PRO 238 676 676 PRO PRO A . n 
A 1 239 GLU 239 677 677 GLU GLU A . n 
A 1 240 MET 240 678 678 MET MET A . n 
A 1 241 GLN 241 679 679 GLN GLN A . n 
A 1 242 ILE 242 680 680 ILE ILE A . n 
A 1 243 LEU 243 681 681 LEU LEU A . n 
A 1 244 ALA 244 682 682 ALA ALA A . n 
A 1 245 VAL 245 683 683 VAL VAL A . n 
A 1 246 SER 246 684 684 SER SER A . n 
A 1 247 GLY 247 685 685 GLY GLY A . n 
A 1 248 ASN 248 686 686 ASN ASN A . n 
A 1 249 TYR 249 687 687 TYR TYR A . n 
A 1 250 CYS 250 688 688 CYS CYS A . n 
A 1 251 THR 251 689 689 THR THR A . n 
A 1 252 ASP 252 690 690 ASP ASP A . n 
A 1 253 LYS 253 691 691 LYS LYS A . n 
A 1 254 LYS 254 692 692 LYS LYS A . n 
A 1 255 PRO 255 693 693 PRO PRO A . n 
A 1 256 ALA 256 694 694 ALA ALA A . n 
A 1 257 ALA 257 695 695 ALA ALA A . n 
A 1 258 ILE 258 696 696 ILE ILE A . n 
A 1 259 ASN 259 697 697 ASN ASN A . n 
A 1 260 TRP 260 698 698 TRP TRP A . n 
A 1 261 ILE 261 699 699 ILE ILE A . n 
A 1 262 GLU 262 700 700 GLU GLU A . n 
A 1 263 GLY 263 701 701 GLY GLY A . n 
A 1 264 ARG 264 702 702 ARG ARG A . n 
A 1 265 GLY 265 703 703 GLY GLY A . n 
A 1 266 LYS 266 704 704 LYS LYS A . n 
A 1 267 SER 267 705 705 SER SER A . n 
A 1 268 VAL 268 706 706 VAL VAL A . n 
A 1 269 VAL 269 707 707 VAL VAL A . n 
A 1 270 CYS 270 708 708 CYS CYS A . n 
A 1 271 GLU 271 709 709 GLU GLU A . n 
A 1 272 ALA 272 710 710 ALA ALA A . n 
A 1 273 VAL 273 711 711 VAL VAL A . n 
A 1 274 ILE 274 712 712 ILE ILE A . n 
A 1 275 PRO 275 713 713 PRO PRO A . n 
A 1 276 ALA 276 714 714 ALA ALA A . n 
A 1 277 LYS 277 715 715 LYS LYS A . n 
A 1 278 VAL 278 716 716 VAL VAL A . n 
A 1 279 VAL 279 717 717 VAL VAL A . n 
A 1 280 ARG 280 718 718 ARG ARG A . n 
A 1 281 GLU 281 719 719 GLU GLU A . n 
A 1 282 VAL 282 720 720 VAL VAL A . n 
A 1 283 LEU 283 721 721 LEU LEU A . n 
A 1 284 LYS 284 722 722 LYS LYS A . n 
A 1 285 THR 285 723 723 THR THR A . n 
A 1 286 THR 286 724 724 THR THR A . n 
A 1 287 THR 287 725 725 THR THR A . n 
A 1 288 GLU 288 726 726 GLU GLU A . n 
A 1 289 ALA 289 727 727 ALA ALA A . n 
A 1 290 MET 290 728 728 MET MET A . n 
A 1 291 ILE 291 729 729 ILE ILE A . n 
A 1 292 GLU 292 730 730 GLU GLU A . n 
A 1 293 VAL 293 731 731 VAL VAL A . n 
A 1 294 ASN 294 732 732 ASN ASN A . n 
A 1 295 ILE 295 733 733 ILE ILE A . n 
A 1 296 ASN 296 734 734 ASN ASN A . n 
A 1 297 LYS 297 735 735 LYS LYS A . n 
A 1 298 ASN 298 736 736 ASN ASN A . n 
A 1 299 LEU 299 737 737 LEU LEU A . n 
A 1 300 VAL 300 738 738 VAL VAL A . n 
A 1 301 GLY 301 739 739 GLY GLY A . n 
A 1 302 SER 302 740 740 SER SER A . n 
A 1 303 ALA 303 741 741 ALA ALA A . n 
A 1 304 MET 304 742 742 MET MET A . n 
A 1 305 ALA 305 743 743 ALA ALA A . n 
A 1 306 GLY 306 744 744 GLY GLY A . n 
A 1 307 SER 307 745 745 SER SER A . n 
A 1 308 ILE 308 746 746 ILE ILE A . n 
A 1 309 GLY 309 747 747 GLY GLY A . n 
A 1 310 GLY 310 748 748 GLY GLY A . n 
A 1 311 TYR 311 749 749 TYR TYR A . n 
A 1 312 ASN 312 750 750 ASN ASN A . n 
A 1 313 ALA 313 751 751 ALA ALA A . n 
A 1 314 HIS 314 752 752 HIS HIS A . n 
A 1 315 ALA 315 753 753 ALA ALA A . n 
A 1 316 ALA 316 754 754 ALA ALA A . n 
A 1 317 ASN 317 755 755 ASN ASN A . n 
A 1 318 ILE 318 756 756 ILE ILE A . n 
A 1 319 VAL 319 757 757 VAL VAL A . n 
A 1 320 THR 320 758 758 THR THR A . n 
A 1 321 ALA 321 759 759 ALA ALA A . n 
A 1 322 ILE 322 760 760 ILE ILE A . n 
A 1 323 TYR 323 761 761 TYR TYR A . n 
A 1 324 ILE 324 762 762 ILE ILE A . n 
A 1 325 ALA 325 763 763 ALA ALA A . n 
A 1 326 CYS 326 764 764 CYS CYS A . n 
A 1 327 GLY 327 765 765 GLY GLY A . n 
A 1 328 GLN 328 766 766 GLN GLN A . n 
A 1 329 ASP 329 767 767 ASP ASP A . n 
A 1 330 ALA 330 768 768 ALA ALA A . n 
A 1 331 ALA 331 769 769 ALA ALA A . n 
A 1 332 GLN 332 770 770 GLN GLN A . n 
A 1 333 ASN 333 771 771 ASN ASN A . n 
A 1 334 VAL 334 772 772 VAL VAL A . n 
A 1 335 GLY 335 773 773 GLY GLY A . n 
A 1 336 SER 336 774 774 SER SER A . n 
A 1 337 SER 337 775 775 SER SER A . n 
A 1 338 ASN 338 776 776 ASN ASN A . n 
A 1 339 CYS 339 777 777 CYS CYS A . n 
A 1 340 ILE 340 778 778 ILE ILE A . n 
A 1 341 THR 341 779 779 THR THR A . n 
A 1 342 LEU 342 780 780 LEU LEU A . n 
A 1 343 MET 343 781 781 MET MET A . n 
A 1 344 GLU 344 782 782 GLU GLU A . n 
A 1 345 ALA 345 783 783 ALA ALA A . n 
A 1 346 SER 346 784 784 SER SER A . n 
A 1 347 GLY 347 785 785 GLY GLY A . n 
A 1 348 PRO 348 786 786 PRO PRO A . n 
A 1 349 THR 349 787 787 THR THR A . n 
A 1 350 ASN 350 788 788 ASN ASN A . n 
A 1 351 GLU 351 789 789 GLU GLU A . n 
A 1 352 ASP 352 790 790 ASP ASP A . n 
A 1 353 LEU 353 791 791 LEU LEU A . n 
A 1 354 TYR 354 792 792 TYR TYR A . n 
A 1 355 ILE 355 793 793 ILE ILE A . n 
A 1 356 SER 356 794 794 SER SER A . n 
A 1 357 CYS 357 795 795 CYS CYS A . n 
A 1 358 THR 358 796 796 THR THR A . n 
A 1 359 MET 359 797 797 MET MET A . n 
A 1 360 PRO 360 798 798 PRO PRO A . n 
A 1 361 SER 361 799 799 SER SER A . n 
A 1 362 ILE 362 800 800 ILE ILE A . n 
A 1 363 GLU 363 801 801 GLU GLU A . n 
A 1 364 ILE 364 802 802 ILE ILE A . n 
A 1 365 GLY 365 803 803 GLY GLY A . n 
A 1 366 THR 366 804 804 THR THR A . n 
A 1 367 VAL 367 805 805 VAL VAL A . n 
A 1 368 GLY 368 806 806 GLY GLY A . n 
A 1 369 GLY 369 807 807 GLY GLY A . n 
A 1 370 GLY 370 808 808 GLY GLY A . n 
A 1 371 THR 371 809 809 THR THR A . n 
A 1 372 ASN 372 810 810 ASN ASN A . n 
A 1 373 LEU 373 811 811 LEU LEU A . n 
A 1 374 LEU 374 812 812 LEU LEU A . n 
A 1 375 PRO 375 813 813 PRO PRO A . n 
A 1 376 GLN 376 814 814 GLN GLN A . n 
A 1 377 GLN 377 815 815 GLN GLN A . n 
A 1 378 ALA 378 816 816 ALA ALA A . n 
A 1 379 CYS 379 817 817 CYS CYS A . n 
A 1 380 LEU 380 818 818 LEU LEU A . n 
A 1 381 GLN 381 819 819 GLN GLN A . n 
A 1 382 MET 382 820 820 MET MET A . n 
A 1 383 LEU 383 821 821 LEU LEU A . n 
A 1 384 GLY 384 822 822 GLY GLY A . n 
A 1 385 VAL 385 823 823 VAL VAL A . n 
A 1 386 GLN 386 824 824 GLN GLN A . n 
A 1 387 GLY 387 825 825 GLY GLY A . n 
A 1 388 ALA 388 826 826 ALA ALA A . n 
A 1 389 CYS 389 827 827 CYS CYS A . n 
A 1 390 LYS 390 828 828 LYS LYS A . n 
A 1 391 ASP 391 829 829 ASP ASP A . n 
A 1 392 ASN 392 830 830 ASN ASN A . n 
A 1 393 PRO 393 831 831 PRO PRO A . n 
A 1 394 GLY 394 832 832 GLY GLY A . n 
A 1 395 GLU 395 833 833 GLU GLU A . n 
A 1 396 ASN 396 834 834 ASN ASN A . n 
A 1 397 ALA 397 835 835 ALA ALA A . n 
A 1 398 ARG 398 836 836 ARG ARG A . n 
A 1 399 GLN 399 837 837 GLN GLN A . n 
A 1 400 LEU 400 838 838 LEU LEU A . n 
A 1 401 ALA 401 839 839 ALA ALA A . n 
A 1 402 ARG 402 840 840 ARG ARG A . n 
A 1 403 ILE 403 841 841 ILE ILE A . n 
A 1 404 VAL 404 842 842 VAL VAL A . n 
A 1 405 CYS 405 843 843 CYS CYS A . n 
A 1 406 GLY 406 844 844 GLY GLY A . n 
A 1 407 THR 407 845 845 THR THR A . n 
A 1 408 VAL 408 846 846 VAL VAL A . n 
A 1 409 MET 409 847 847 MET MET A . n 
A 1 410 ALA 410 848 848 ALA ALA A . n 
A 1 411 GLY 411 849 849 GLY GLY A . n 
A 1 412 GLU 412 850 850 GLU GLU A . n 
A 1 413 LEU 413 851 851 LEU LEU A . n 
A 1 414 SER 414 852 852 SER SER A . n 
A 1 415 LEU 415 853 853 LEU LEU A . n 
A 1 416 MET 416 854 854 MET MET A . n 
A 1 417 ALA 417 855 855 ALA ALA A . n 
A 1 418 ALA 418 856 856 ALA ALA A . n 
A 1 419 LEU 419 857 857 LEU LEU A . n 
A 1 420 ALA 420 858 858 ALA ALA A . n 
A 1 421 ALA 421 859 859 ALA ALA A . n 
A 1 422 GLY 422 860 860 GLY GLY A . n 
A 1 423 HIS 423 861 861 HIS HIS A . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8S6B 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8S6B 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8S6B 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               65.189 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.902 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8S6B 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.060 
_refine.ls_d_res_low                             148.000 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  327665 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    100.000 
_refine.ls_percent_reflns_R_free                 0.000 
_refine.ls_R_factor_all                          0.347 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.3475 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      0.347 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    NONE 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.072 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             3.133 
_refine.overall_SU_ML                            0.080 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 0.8476 
_refine.pdbx_average_fsc_work                    0.8476 
_refine.pdbx_average_fsc_free                    0.0000 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004  0.012  3198  ? r_bond_refined_d               ? ? 
'ELECTRON MICROSCOPY' ? 0.000  0.016  3105  ? r_bond_other_d                 ? ? 
'ELECTRON MICROSCOPY' ? 1.120  1.816  4322  ? r_angle_refined_deg            ? ? 
'ELECTRON MICROSCOPY' ? 0.396  1.741  7158  ? r_angle_other_deg              ? ? 
'ELECTRON MICROSCOPY' ? 5.281  5.000  422   ? r_dihedral_angle_1_deg         ? ? 
'ELECTRON MICROSCOPY' ? 17.038 5.000  21    ? r_dihedral_angle_2_deg         ? ? 
'ELECTRON MICROSCOPY' ? 17.713 10.000 561   ? r_dihedral_angle_3_deg         ? ? 
'ELECTRON MICROSCOPY' ? 15.354 10.000 125   ? r_dihedral_angle_6_deg         ? ? 
'ELECTRON MICROSCOPY' ? 0.052  0.200  496   ? r_chiral_restr                 ? ? 
'ELECTRON MICROSCOPY' ? 0.004  0.020  3796  ? r_gen_planes_refined           ? ? 
'ELECTRON MICROSCOPY' ? 0.001  0.020  688   ? r_gen_planes_other             ? ? 
'ELECTRON MICROSCOPY' ? 0.227  0.200  688   ? r_nbd_refined                  ? ? 
'ELECTRON MICROSCOPY' ? 0.213  0.200  2907  ? r_symmetry_nbd_other           ? ? 
'ELECTRON MICROSCOPY' ? 0.182  0.200  1663  ? r_nbtor_refined                ? ? 
'ELECTRON MICROSCOPY' ? 0.079  0.200  1837  ? r_symmetry_nbtor_other         ? ? 
'ELECTRON MICROSCOPY' ? 0.184  0.200  48    ? r_xyhbond_nbd_refined          ? ? 
'ELECTRON MICROSCOPY' ? 0.203  0.200  38    ? r_symmetry_nbd_refined         ? ? 
'ELECTRON MICROSCOPY' ? 0.142  0.200  196   ? r_nbd_other                    ? ? 
'ELECTRON MICROSCOPY' ? 0.156  0.200  20    ? r_symmetry_xyhbond_nbd_refined ? ? 
'ELECTRON MICROSCOPY' ? 3.086  6.091  1691  ? r_mcbond_it                    ? ? 
'ELECTRON MICROSCOPY' ? 3.086  6.091  1691  ? r_mcbond_other                 ? ? 
'ELECTRON MICROSCOPY' ? 4.464  10.940 2112  ? r_mcangle_it                   ? ? 
'ELECTRON MICROSCOPY' ? 4.463  10.945 2113  ? r_mcangle_other                ? ? 
'ELECTRON MICROSCOPY' ? 4.497  7.001  1507  ? r_scbond_it                    ? ? 
'ELECTRON MICROSCOPY' ? 4.495  7.007  1508  ? r_scbond_other                 ? ? 
'ELECTRON MICROSCOPY' ? 7.328  12.513 2210  ? r_scangle_it                   ? ? 
'ELECTRON MICROSCOPY' ? 7.326  12.517 2211  ? r_scangle_other                ? ? 
'ELECTRON MICROSCOPY' ? 9.907  75.465 13574 ? r_lrange_it                    ? ? 
'ELECTRON MICROSCOPY' ? 9.907  75.475 13575 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'ELECTRON MICROSCOPY' 2.060 2.114   24231 . 0 24231 100.0000 . 2.057 . . 2.057 . . . . . 2.057 . 20 . 0.598 . . 
'ELECTRON MICROSCOPY' 2.114 2.171   23670 . 0 23670 100.0000 . 1.371 . . 1.371 . . . . . 1.371 . 20 . 0.712 . . 
'ELECTRON MICROSCOPY' 2.171 2.234   23057 . 0 23057 100.0000 . 1.164 . . 1.164 . . . . . 1.164 . 20 . 0.766 . . 
'ELECTRON MICROSCOPY' 2.234 2.303   22206 . 0 22206 100.0000 . 0.941 . . 0.941 . . . . . 0.941 . 20 . 0.809 . . 
'ELECTRON MICROSCOPY' 2.303 2.379   21634 . 0 21634 100.0000 . 0.743 . . 0.743 . . . . . 0.743 . 20 . 0.835 . . 
'ELECTRON MICROSCOPY' 2.379 2.462   20868 . 0 20868 100.0000 . 0.633 . . 0.633 . . . . . 0.633 . 20 . 0.847 . . 
'ELECTRON MICROSCOPY' 2.462 2.555   20291 . 0 20291 100.0000 . 0.505 . . 0.505 . . . . . 0.505 . 20 . 0.868 . . 
'ELECTRON MICROSCOPY' 2.555 2.659   19366 . 0 19366 100.0000 . 0.401 . . 0.401 . . . . . 0.401 . 20 . 0.883 . . 
'ELECTRON MICROSCOPY' 2.659 2.777   18667 . 0 18667 100.0000 . 0.327 . . 0.327 . . . . . 0.327 . 20 . 0.901 . . 
'ELECTRON MICROSCOPY' 2.777 2.913   17846 . 0 17846 100.0000 . 0.282 . . 0.282 . . . . . 0.282 . 20 . 0.911 . . 
'ELECTRON MICROSCOPY' 2.913 3.071   16869 . 0 16869 100.0000 . 0.279 . . 0.279 . . . . . 0.279 . 20 . 0.915 . . 
'ELECTRON MICROSCOPY' 3.071 3.257   15999 . 0 15999 100.0000 . 0.275 . . 0.275 . . . . . 0.275 . 20 . 0.924 . . 
'ELECTRON MICROSCOPY' 3.257 3.481   15123 . 0 15123 100.0000 . 0.284 . . 0.284 . . . . . 0.284 . 20 . 0.931 . . 
'ELECTRON MICROSCOPY' 3.481 3.760   13893 . 0 13893 100.0000 . 0.300 . . 0.300 . . . . . 0.300 . 20 . 0.932 . . 
'ELECTRON MICROSCOPY' 3.760 4.119   12908 . 0 12908 100.0000 . 0.306 . . 0.306 . . . . . 0.306 . 20 . 0.935 . . 
'ELECTRON MICROSCOPY' 4.119 4.605   11690 . 0 11690 100.0000 . 0.291 . . 0.291 . . . . . 0.291 . 20 . 0.943 . . 
'ELECTRON MICROSCOPY' 4.605 5.316   10281 . 0 10281 100.0000 . 0.265 . . 0.265 . . . . . 0.265 . 20 . 0.931 . . 
'ELECTRON MICROSCOPY' 5.316 6.509   8673  . 0 8673  100.0000 . 0.325 . . 0.325 . . . . . 0.325 . 20 . 0.902 . . 
'ELECTRON MICROSCOPY' 6.509 9.196   6723  . 0 6723  100.0000 . 0.340 . . 0.340 . . . . . 0.340 . 20 . 0.890 . . 
'ELECTRON MICROSCOPY' 9.196 148.000 3670  . 0 3670  100.0000 . 0.408 . . 0.408 . . . . . 0.408 . 20 . 0.951 . . 
# 
loop_
_struct_ncs_oper.id 
_struct_ncs_oper.code 
_struct_ncs_oper.matrix[1][1] 
_struct_ncs_oper.matrix[1][2] 
_struct_ncs_oper.matrix[1][3] 
_struct_ncs_oper.vector[1] 
_struct_ncs_oper.matrix[2][1] 
_struct_ncs_oper.matrix[2][2] 
_struct_ncs_oper.matrix[2][3] 
_struct_ncs_oper.vector[2] 
_struct_ncs_oper.matrix[3][1] 
_struct_ncs_oper.matrix[3][2] 
_struct_ncs_oper.matrix[3][3] 
_struct_ncs_oper.vector[3] 
_struct_ncs_oper.details 
1 given    1  0 0 0   0 1  0 0   0 0 1  0   ? 
2 generate -1 0 0 222 0 -1 0 222 0 0 1  0   ? 
3 generate 1  0 0 0   0 -1 0 222 0 0 -1 222 ? 
4 generate -1 0 0 222 0 1  0 0   0 0 -1 222 ? 
# 
_struct.entry_id                     8S6B 
_struct.title                        'CryoEM structure of Apo form of catalytic domain of human HMG-CoA reductase' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8S6B 
_struct_keywords.text            'reductase, cholesterol biosynthesis, lipitor, atorvastatin, statins, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HMDH_HUMAN 
_struct_ref.pdbx_db_accession          P04035 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;PREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYN
YSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEM
QILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVT
AIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL
ARIVCGTVMAGELSLMAALAAGH
;
_struct_ref.pdbx_align_begin           439 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8S6B 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 423 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P04035 
_struct_ref_seq.db_align_beg                  439 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  861 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       439 
_struct_ref_seq.pdbx_auth_seq_align_end       861 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3,4 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'       1_555 x,y,z 1.000000  0.000000 0.000000 0.00000   0.000000 1.000000  0.000000 0.00000   0.000000 
0.000000 1.000000  0.00000   
2 'point symmetry operation' ?     ?     -1.000000 0.000000 0.000000 222.00000 0.000000 -1.000000 0.000000 222.00000 0.000000 
0.000000 1.000000  0.00000   
3 'point symmetry operation' ?     ?     1.000000  0.000000 0.000000 0.00000   0.000000 -1.000000 0.000000 222.00000 0.000000 
0.000000 -1.000000 222.00000 
4 'point symmetry operation' ?     ?     -1.000000 0.000000 0.000000 222.00000 0.000000 1.000000  0.000000 0.00000   0.000000 
0.000000 -1.000000 222.00000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 6   ? ASN A 16  ? PRO A 444 ASN A 454 1 ? 11 
HELX_P HELX_P2  AA2 SER A 25  ? ALA A 35  ? SER A 463 ALA A 473 1 ? 11 
HELX_P HELX_P3  AA3 PRO A 39  ? TYR A 41  ? PRO A 477 TYR A 479 5 ? 3  
HELX_P HELX_P4  AA4 LYS A 42  ? MET A 47  ? LYS A 480 MET A 485 1 ? 6  
HELX_P HELX_P5  AA5 THR A 49  ? LYS A 64  ? THR A 487 LYS A 502 1 ? 16 
HELX_P HELX_P6  AA6 SER A 69  ? LEU A 74  ? SER A 507 LEU A 512 5 ? 6  
HELX_P HELX_P7  AA7 CYS A 123 ? GLY A 138 ? CYS A 561 GLY A 576 1 ? 16 
HELX_P HELX_P8  AA8 ARG A 160 ? THR A 173 ? ARG A 598 THR A 611 1 ? 14 
HELX_P HELX_P9  AA9 THR A 173 ? SER A 186 ? THR A 611 SER A 624 1 ? 14 
HELX_P HELX_P10 AB1 GLY A 218 ? PHE A 237 ? GLY A 656 PHE A 675 1 ? 20 
HELX_P HELX_P11 AB2 ALA A 256 ? GLY A 263 ? ALA A 694 GLY A 701 1 ? 8  
HELX_P HELX_P12 AB3 PRO A 275 ? VAL A 282 ? PRO A 713 VAL A 720 1 ? 8  
HELX_P HELX_P13 AB4 THR A 286 ? LEU A 299 ? THR A 724 LEU A 737 1 ? 14 
HELX_P HELX_P14 AB5 LEU A 299 ? ALA A 305 ? LEU A 737 ALA A 743 1 ? 7  
HELX_P HELX_P15 AB6 HIS A 314 ? CYS A 326 ? HIS A 752 CYS A 764 1 ? 13 
HELX_P HELX_P16 AB7 ASP A 329 ? ALA A 331 ? ASP A 767 ALA A 769 5 ? 3  
HELX_P HELX_P17 AB8 GLN A 332 ? SER A 337 ? GLN A 770 SER A 775 1 ? 6  
HELX_P HELX_P18 AB9 GLY A 368 ? ASN A 372 ? GLY A 806 ASN A 810 5 ? 5  
HELX_P HELX_P19 AC1 LEU A 373 ? LEU A 383 ? LEU A 811 LEU A 821 1 ? 11 
HELX_P HELX_P20 AC2 GLY A 394 ? GLY A 422 ? GLY A 832 GLY A 860 1 ? 29 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 104 A . ? GLY 542 A PRO 105 A ? PRO 543 A 1 2.47  
2 CYS 250 A . ? CYS 688 A THR 251 A ? THR 689 A 1 -1.62 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 4 ? 
AA3 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA3 6 7 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 100 ? LEU A 108 ? VAL A 538 LEU A 546 
AA1 2 LYS A 111 ? ALA A 118 ? LYS A 549 ALA A 556 
AA2 1 ARG A 192 ? LEU A 193 ? ARG A 630 LEU A 631 
AA2 2 ASN A 204 ? ARG A 212 ? ASN A 642 ARG A 650 
AA2 3 VAL A 155 ? ARG A 157 ? VAL A 593 ARG A 595 
AA2 4 GLN A 241 ? ALA A 244 ? GLN A 679 ALA A 682 
AA3 1 HIS A 197 ? ALA A 201 ? HIS A 635 ALA A 639 
AA3 2 ASN A 204 ? ARG A 212 ? ASN A 642 ARG A 650 
AA3 3 SER A 142 ? ARG A 152 ? SER A 580 ARG A 590 
AA3 4 GLY A 265 ? ILE A 274 ? GLY A 703 ILE A 712 
AA3 5 ASP A 352 ? ILE A 362 ? ASP A 790 ILE A 800 
AA3 6 CYS A 339 ? SER A 346 ? CYS A 777 SER A 784 
AA3 7 GLY A 310 ? TYR A 311 ? GLY A 748 TYR A 749 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 101 ? N GLY A 539 O MET A 117 ? O MET A 555 
AA2 1 2 O ARG A 192 ? O ARG A 630 N ARG A 212 ? N ARG A 650 
AA2 2 3 O LEU A 205 ? O LEU A 643 N VAL A 156 ? N VAL A 594 
AA2 3 4 N ARG A 157 ? N ARG A 595 O GLN A 241 ? O GLN A 679 
AA3 1 2 N SER A 199 ? N SER A 637 O TYR A 206 ? O TYR A 644 
AA3 2 3 O PHE A 209 ? O PHE A 647 N ARG A 152 ? N ARG A 590 
AA3 3 4 N LEU A 146 ? N LEU A 584 O SER A 267 ? O SER A 705 
AA3 4 5 N ILE A 274 ? N ILE A 712 O LEU A 353 ? O LEU A 791 
AA3 5 6 O SER A 356 ? O SER A 794 N LEU A 342 ? N LEU A 780 
AA3 6 7 O THR A 341 ? O THR A 779 N TYR A 311 ? N TYR A 749 
# 
_pdbx_entry_details.entry_id                   8S6B 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              443 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              443 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH2 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              443 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                116.75 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -3.55 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 440 ? ? -174.74 -166.14 
2 1 LYS A 460 ? ? 113.80  -24.36  
3 1 ALA A 525 ? ? -132.01 -45.32  
4 1 CYS A 561 ? ? 83.12   -8.25   
5 1 SER A 651 ? ? -142.49 34.37   
6 1 LEU A 737 ? ? -97.47  -62.98  
7 1 TYR A 749 ? ? -95.17  58.16   
8 1 HIS A 752 ? ? -152.07 43.74   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 440 ? ? 0.084 'SIDE CHAIN' 
2 1 ARG A 443 ? ? 0.232 'SIDE CHAIN' 
3 1 ARG A 590 ? ? 0.166 'SIDE CHAIN' 
4 1 ARG A 595 ? ? 0.189 'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8S6B 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'FLEXIBLE FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1hwk 
_em_3d_fitting_list.pdb_chain_id                  A 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      A 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1hwk 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    8S6B 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.06 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               1066707 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'human HMGCoA catalytic domain reductase' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8S6B 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            50.0 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8S6B 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8S6B 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              8S6B 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        D2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-02-27 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           8S6B 
_em_admin.last_update        2025-03-12 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'CryoEM structure of Apo form of catalytic domain of human HMG-CoA reductase' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.24 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              Falcon4i 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         54.8 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     13644 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   5498554 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? Topaz  0.2.5 
'IMAGE ACQUISITION'        ? 2  ? ? 1 EPU    3.8   
MASKING                    ? 3  ? ? ? ?      ?     
'CTF CORRECTION'           ? 4  1 ? ? RELION 5     
'LAYERLINE INDEXING'       ? 5  ? ? ? ?      ?     
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?      ?     
'MODEL FITTING'            ? 7  ? 1 ? Coot   ?     
OTHER                      ? 8  ? ? ? ?      ?     
'INITIAL EULER ASSIGNMENT' ? 9  1 ? ? RELION 5     
'FINAL EULER ASSIGNMENT'   ? 10 1 ? ? RELION 5     
CLASSIFICATION             ? 11 1 ? ? RELION 5     
RECONSTRUCTION             ? 12 1 ? ? RELION 5     
'MODEL REFINEMENT'         ? 13 ? 1 ? REFMAC ?     
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Diamond Light Source' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1hwk 
# 
_atom_sites.entry_id                    8S6B 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 0.8669   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . PRO A 1 1   ? 173.871 90.506  100.881 1 169.678 ? 439 PRO A N   1 
ATOM 2    C CA  . PRO A 1 1   ? 172.561 89.793  100.923 1 168.377 ? 439 PRO A CA  1 
ATOM 3    C C   . PRO A 1 1   ? 172.64  88.581  101.847 1 165.423 ? 439 PRO A C   1 
ATOM 4    O O   . PRO A 1 1   ? 173.567 88.457  102.647 1 162.066 ? 439 PRO A O   1 
ATOM 5    C CB  . PRO A 1 1   ? 172.338 89.417  99.461  1 169.131 ? 439 PRO A CB  1 
ATOM 6    C CG  . PRO A 1 1   ? 173.729 88.965  99.061  1 169.342 ? 439 PRO A CG  1 
ATOM 7    C CD  . PRO A 1 1   ? 174.683 89.876  99.788  1 170.084 ? 439 PRO A CD  1 
ATOM 8    N N   . ARG A 1 2   ? 171.642 87.702  101.722 1 161.366 ? 440 ARG A N   1 
ATOM 9    C CA  . ARG A 1 2   ? 171.598 86.424  102.419 1 158.06  ? 440 ARG A CA  1 
ATOM 10   C C   . ARG A 1 2   ? 170.379 85.653  101.921 1 153.887 ? 440 ARG A C   1 
ATOM 11   O O   . ARG A 1 2   ? 169.799 86.012  100.903 1 151.878 ? 440 ARG A O   1 
ATOM 12   C CB  . ARG A 1 2   ? 171.518 86.574  103.942 1 160.866 ? 440 ARG A CB  1 
ATOM 13   C CG  . ARG A 1 2   ? 171.507 85.249  104.694 1 162.959 ? 440 ARG A CG  1 
ATOM 14   C CD  . ARG A 1 2   ? 171.405 85.455  106.171 1 165.265 ? 440 ARG A CD  1 
ATOM 15   N NE  . ARG A 1 2   ? 172.552 86.225  106.652 1 168.514 ? 440 ARG A NE  1 
ATOM 16   C CZ  . ARG A 1 2   ? 172.738 86.569  107.909 1 173.273 ? 440 ARG A CZ  1 
ATOM 17   N NH1 . ARG A 1 2   ? 172.117 85.931  108.891 1 171.892 ? 440 ARG A NH1 1 
ATOM 18   N NH2 . ARG A 1 2   ? 173.608 87.52   108.184 1 175.496 ? 440 ARG A NH2 1 
ATOM 19   N N   . GLU A 1 3   ? 169.999 84.587  102.633 1 147.962 ? 441 GLU A N   1 
ATOM 20   C CA  . GLU A 1 3   ? 168.908 83.739  102.196 1 147.097 ? 441 GLU A CA  1 
ATOM 21   C C   . GLU A 1 3   ? 168.202 83.14   103.409 1 140.828 ? 441 GLU A C   1 
ATOM 22   O O   . GLU A 1 3   ? 168.774 83.086  104.495 1 140.132 ? 441 GLU A O   1 
ATOM 23   C CB  . GLU A 1 3   ? 169.444 82.706  101.203 1 152.218 ? 441 GLU A CB  1 
ATOM 24   C CG  . GLU A 1 3   ? 170.96  82.508  101.221 1 156.265 ? 441 GLU A CG  1 
ATOM 25   C CD  . GLU A 1 3   ? 171.562 81.881  102.469 1 160.822 ? 441 GLU A CD  1 
ATOM 26   O OE1 . GLU A 1 3   ? 171.823 82.607  103.449 1 159.354 ? 441 GLU A OE1 1 
ATOM 27   O OE2 . GLU A 1 3   ? 171.767 80.648  102.454 1 160.61  ? 441 GLU A OE2 1 
ATOM 28   N N   . PRO A 1 4   ? 166.934 82.685  103.253 1 134.547 ? 442 PRO A N   1 
ATOM 29   C CA  . PRO A 1 4   ? 166.111 82.264  104.386 1 132.396 ? 442 PRO A CA  1 
ATOM 30   C C   . PRO A 1 4   ? 166.423 80.879  104.956 1 128.019 ? 442 PRO A C   1 
ATOM 31   O O   . PRO A 1 4   ? 166.436 79.879  104.237 1 131.641 ? 442 PRO A O   1 
ATOM 32   C CB  . PRO A 1 4   ? 164.692 82.305  103.821 1 132.142 ? 442 PRO A CB  1 
ATOM 33   C CG  . PRO A 1 4   ? 164.89  82.017  102.342 1 133.408 ? 442 PRO A CG  1 
ATOM 34   C CD  . PRO A 1 4   ? 166.211 82.629  101.969 1 134.873 ? 442 PRO A CD  1 
ATOM 35   N N   . ARG A 1 5   ? 166.615 80.824  106.279 1 123.817 ? 443 ARG A N   1 
ATOM 36   C CA  . ARG A 1 5   ? 166.828 79.56   106.961 1 123.219 ? 443 ARG A CA  1 
ATOM 37   C C   . ARG A 1 5   ? 165.518 78.778  106.998 1 122.812 ? 443 ARG A C   1 
ATOM 38   O O   . ARG A 1 5   ? 164.445 79.374  106.95  1 122.626 ? 443 ARG A O   1 
ATOM 39   C CB  . ARG A 1 5   ? 167.392 79.831  108.359 1 123.288 ? 443 ARG A CB  1 
ATOM 40   C CG  . ARG A 1 5   ? 168.81  80.37   108.287 1 123.501 ? 443 ARG A CG  1 
ATOM 41   C CD  . ARG A 1 5   ? 169.462 80.324  109.639 1 125.603 ? 443 ARG A CD  1 
ATOM 42   N NE  . ARG A 1 5   ? 168.871 81.164  110.682 1 125.87  ? 443 ARG A NE  1 
ATOM 43   C CZ  . ARG A 1 5   ? 169.117 82.45   110.824 1 126.718 ? 443 ARG A CZ  1 
ATOM 44   N NH1 . ARG A 1 5   ? 168.824 83.342  109.894 1 125.56  ? 443 ARG A NH1 1 
ATOM 45   N NH2 . ARG A 1 5   ? 169.524 82.849  112.014 1 127.782 ? 443 ARG A NH2 1 
ATOM 46   N N   . PRO A 1 6   ? 165.559 77.425  107.049 1 124.564 ? 444 PRO A N   1 
ATOM 47   C CA  . PRO A 1 6   ? 164.343 76.623  107.157 1 123.74  ? 444 PRO A CA  1 
ATOM 48   C C   . PRO A 1 6   ? 163.491 76.986  108.369 1 121.968 ? 444 PRO A C   1 
ATOM 49   O O   . PRO A 1 6   ? 163.974 77.634  109.293 1 120.051 ? 444 PRO A O   1 
ATOM 50   C CB  . PRO A 1 6   ? 164.855 75.183  107.244 1 123.44  ? 444 PRO A CB  1 
ATOM 51   C CG  . PRO A 1 6   ? 166.314 75.325  107.649 1 124.867 ? 444 PRO A CG  1 
ATOM 52   C CD  . PRO A 1 6   ? 166.774 76.596  107.004 1 125.742 ? 444 PRO A CD  1 
ATOM 53   N N   . ASN A 1 7   ? 162.233 76.53   108.362 1 121.435 ? 445 ASN A N   1 
ATOM 54   C CA  . ASN A 1 7   ? 161.249 76.888  109.375 1 123.126 ? 445 ASN A CA  1 
ATOM 55   C C   . ASN A 1 7   ? 161.634 76.38   110.765 1 126.043 ? 445 ASN A C   1 
ATOM 56   O O   . ASN A 1 7   ? 161.768 77.173  111.694 1 122.628 ? 445 ASN A O   1 
ATOM 57   C CB  . ASN A 1 7   ? 159.86  76.368  109.018 1 123.647 ? 445 ASN A CB  1 
ATOM 58   C CG  . ASN A 1 7   ? 159.119 77.291  108.078 1 125.212 ? 445 ASN A CG  1 
ATOM 59   O OD1 . ASN A 1 7   ? 159.335 78.509  108.09  1 123.953 ? 445 ASN A OD1 1 
ATOM 60   N ND2 . ASN A 1 7   ? 158.222 76.738  107.274 1 125.533 ? 445 ASN A ND2 1 
ATOM 61   N N   . GLU A 1 8   ? 161.754 75.06   110.917 1 130.551 ? 446 GLU A N   1 
ATOM 62   C CA  . GLU A 1 8   ? 162.035 74.448  112.21  1 132.836 ? 446 GLU A CA  1 
ATOM 63   C C   . GLU A 1 8   ? 163.21  75.166  112.873 1 128.413 ? 446 GLU A C   1 
ATOM 64   O O   . GLU A 1 8   ? 163.136 75.555  114.041 1 124.592 ? 446 GLU A O   1 
ATOM 65   C CB  . GLU A 1 8   ? 162.241 72.938  112.071 1 138.45  ? 446 GLU A CB  1 
ATOM 66   C CG  . GLU A 1 8   ? 162.257 72.423  110.633 1 144.067 ? 446 GLU A CG  1 
ATOM 67   C CD  . GLU A 1 8   ? 160.881 72.314  109.984 1 148.359 ? 446 GLU A CD  1 
ATOM 68   O OE1 . GLU A 1 8   ? 160.714 72.723  108.81  1 148.197 ? 446 GLU A OE1 1 
ATOM 69   O OE2 . GLU A 1 8   ? 159.96  71.828  110.674 1 149.889 ? 446 GLU A OE2 1 
ATOM 70   N N   . GLU A 1 9   ? 164.272 75.387  112.095 1 125.179 ? 447 GLU A N   1 
ATOM 71   C CA  . GLU A 1 9   ? 165.406 76.178  112.539 1 125.496 ? 447 GLU A CA  1 
ATOM 72   C C   . GLU A 1 9   ? 164.952 77.547  113.048 1 123.719 ? 447 GLU A C   1 
ATOM 73   O O   . GLU A 1 9   ? 165.28  77.926  114.168 1 123.409 ? 447 GLU A O   1 
ATOM 74   C CB  . GLU A 1 9   ? 166.404 76.31   111.39  1 128.318 ? 447 GLU A CB  1 
ATOM 75   C CG  . GLU A 1 9   ? 167.389 77.461  111.569 1 132.072 ? 447 GLU A CG  1 
ATOM 76   C CD  . GLU A 1 9   ? 168.745 77.195  110.943 1 135.934 ? 447 GLU A CD  1 
ATOM 77   O OE1 . GLU A 1 9   ? 168.807 76.532  109.884 1 135.794 ? 447 GLU A OE1 1 
ATOM 78   O OE2 . GLU A 1 9   ? 169.747 77.675  111.515 1 137.386 ? 447 GLU A OE2 1 
ATOM 79   N N   . CYS A 1 10  ? 164.213 78.29   112.215 1 122.103 ? 448 CYS A N   1 
ATOM 80   C CA  . CYS A 1 10  ? 163.85  79.672  112.507 1 117.997 ? 448 CYS A CA  1 
ATOM 81   C C   . CYS A 1 10  ? 162.957 79.756  113.747 1 115.901 ? 448 CYS A C   1 
ATOM 82   O O   . CYS A 1 10  ? 163.102 80.663  114.567 1 112.917 ? 448 CYS A O   1 
ATOM 83   C CB  . CYS A 1 10  ? 163.177 80.32   111.301 1 117.427 ? 448 CYS A CB  1 
ATOM 84   S SG  . CYS A 1 10  ? 164.335 81.048  110.112 1 118.007 ? 448 CYS A SG  1 
ATOM 85   N N   . LEU A 1 11  ? 162.066 78.773  113.901 1 115.658 ? 449 LEU A N   1 
ATOM 86   C CA  . LEU A 1 11  ? 161.137 78.729  115.017 1 118.465 ? 449 LEU A CA  1 
ATOM 87   C C   . LEU A 1 11  ? 161.864 78.615  116.359 1 123.655 ? 449 LEU A C   1 
ATOM 88   O O   . LEU A 1 11  ? 161.25  78.851  117.401 1 125.263 ? 449 LEU A O   1 
ATOM 89   C CB  . LEU A 1 11  ? 160.164 77.567  114.815 1 116.917 ? 449 LEU A CB  1 
ATOM 90   C CG  . LEU A 1 11  ? 158.701 77.946  114.565 1 120.4   ? 449 LEU A CG  1 
ATOM 91   C CD1 . LEU A 1 11  ? 157.819 76.717  114.705 1 121.43  ? 449 LEU A CD1 1 
ATOM 92   C CD2 . LEU A 1 11  ? 158.252 79.04   115.523 1 120.695 ? 449 LEU A CD2 1 
ATOM 93   N N   . GLN A 1 12  ? 163.155 78.246  116.327 1 125.798 ? 450 GLN A N   1 
ATOM 94   C CA  . GLN A 1 12  ? 163.954 78.065  117.53  1 126.595 ? 450 GLN A CA  1 
ATOM 95   C C   . GLN A 1 12  ? 164.593 79.379  117.965 1 123.654 ? 450 GLN A C   1 
ATOM 96   O O   . GLN A 1 12  ? 164.531 79.716  119.144 1 124.273 ? 450 GLN A O   1 
ATOM 97   C CB  . GLN A 1 12  ? 165.066 77.037  117.339 1 131.654 ? 450 GLN A CB  1 
ATOM 98   C CG  . GLN A 1 12  ? 164.559 75.609  117.188 1 137.059 ? 450 GLN A CG  1 
ATOM 99   C CD  . GLN A 1 12  ? 165.611 74.667  116.647 1 141.048 ? 450 GLN A CD  1 
ATOM 100  O OE1 . GLN A 1 12  ? 166.777 75.033  116.455 1 140.897 ? 450 GLN A OE1 1 
ATOM 101  N NE2 . GLN A 1 12  ? 165.202 73.433  116.393 1 142.105 ? 450 GLN A NE2 1 
ATOM 102  N N   . ILE A 1 13  ? 165.216 80.115  117.036 1 117.519 ? 451 ILE A N   1 
ATOM 103  C CA  . ILE A 1 13  ? 165.75  81.423  117.384 1 117.421 ? 451 ILE A CA  1 
ATOM 104  C C   . ILE A 1 13  ? 164.642 82.221  118.073 1 119.286 ? 451 ILE A C   1 
ATOM 105  O O   . ILE A 1 13  ? 164.835 82.747  119.168 1 120.896 ? 451 ILE A O   1 
ATOM 106  C CB  . ILE A 1 13  ? 166.334 82.157  116.16  1 117.558 ? 451 ILE A CB  1 
ATOM 107  C CG1 . ILE A 1 13  ? 167.569 81.44   115.619 1 117.542 ? 451 ILE A CG1 1 
ATOM 108  C CG2 . ILE A 1 13  ? 166.646 83.62   116.476 1 117.162 ? 451 ILE A CG2 1 
ATOM 109  C CD1 . ILE A 1 13  ? 167.282 80.45   114.511 1 117.397 ? 451 ILE A CD1 1 
ATOM 110  N N   . LEU A 1 14  ? 163.457 82.238  117.456 1 123.256 ? 452 LEU A N   1 
ATOM 111  C CA  . LEU A 1 14  ? 162.302 82.933  118.001 1 124.695 ? 452 LEU A CA  1 
ATOM 112  C C   . LEU A 1 14  ? 162.136 82.606  119.491 1 128.839 ? 452 LEU A C   1 
ATOM 113  O O   . LEU A 1 14  ? 161.835 83.493  120.291 1 128.477 ? 452 LEU A O   1 
ATOM 114  C CB  . LEU A 1 14  ? 161.075 82.538  117.173 1 123.387 ? 452 LEU A CB  1 
ATOM 115  C CG  . LEU A 1 14  ? 160.194 83.684  116.659 1 121.559 ? 452 LEU A CG  1 
ATOM 116  C CD1 . LEU A 1 14  ? 158.745 83.231  116.581 1 121.397 ? 452 LEU A CD1 1 
ATOM 117  C CD2 . LEU A 1 14  ? 160.308 84.953  117.49  1 120.589 ? 452 LEU A CD2 1 
ATOM 118  N N   . GLY A 1 15  ? 162.368 81.334  119.856 1 131.204 ? 453 GLY A N   1 
ATOM 119  C CA  . GLY A 1 15  ? 162.231 80.84   121.22  1 133.951 ? 453 GLY A CA  1 
ATOM 120  C C   . GLY A 1 15  ? 163.396 81.213  122.142 1 134.671 ? 453 GLY A C   1 
ATOM 121  O O   . GLY A 1 15  ? 163.157 81.558  123.298 1 135.133 ? 453 GLY A O   1 
ATOM 122  N N   . ASN A 1 16  ? 164.648 81.11   121.666 1 134.231 ? 454 ASN A N   1 
ATOM 123  C CA  . ASN A 1 16  ? 165.798 81.515  122.467 1 137.269 ? 454 ASN A CA  1 
ATOM 124  C C   . ASN A 1 16  ? 165.557 82.914  123.031 1 137.104 ? 454 ASN A C   1 
ATOM 125  O O   . ASN A 1 16  ? 165.376 83.863  122.273 1 136.322 ? 454 ASN A O   1 
ATOM 126  C CB  . ASN A 1 16  ? 167.103 81.474  121.676 1 138.957 ? 454 ASN A CB  1 
ATOM 127  C CG  . ASN A 1 16  ? 167.645 80.071  121.528 1 143.569 ? 454 ASN A CG  1 
ATOM 128  O OD1 . ASN A 1 16  ? 167.159 79.135  122.175 1 141.387 ? 454 ASN A OD1 1 
ATOM 129  N ND2 . ASN A 1 16  ? 168.667 79.906  120.7   1 143.276 ? 454 ASN A ND2 1 
ATOM 130  N N   . ALA A 1 17  ? 165.556 83.035  124.366 1 137.268 ? 455 ALA A N   1 
ATOM 131  C CA  . ALA A 1 17  ? 165.196 84.284  125.019 1 138.883 ? 455 ALA A CA  1 
ATOM 132  C C   . ALA A 1 17  ? 166.407 85.205  125.162 1 138.929 ? 455 ALA A C   1 
ATOM 133  O O   . ALA A 1 17  ? 166.277 86.301  125.704 1 137.297 ? 455 ALA A O   1 
ATOM 134  C CB  . ALA A 1 17  ? 164.558 83.995  126.361 1 139.281 ? 455 ALA A CB  1 
ATOM 135  N N   . GLU A 1 18  ? 167.583 84.753  124.705 1 138.957 ? 456 GLU A N   1 
ATOM 136  C CA  . GLU A 1 18  ? 168.758 85.61   124.64  1 142.671 ? 456 GLU A CA  1 
ATOM 137  C C   . GLU A 1 18  ? 169.076 85.913  123.178 1 140.597 ? 456 GLU A C   1 
ATOM 138  O O   . GLU A 1 18  ? 169.856 86.819  122.893 1 137.828 ? 456 GLU A O   1 
ATOM 139  C CB  . GLU A 1 18  ? 169.914 84.954  125.396 1 148.066 ? 456 GLU A CB  1 
ATOM 140  C CG  . GLU A 1 18  ? 171.004 85.927  125.84  1 152.041 ? 456 GLU A CG  1 
ATOM 141  C CD  . GLU A 1 18  ? 172.211 86.015  124.923 1 157.38  ? 456 GLU A CD  1 
ATOM 142  O OE1 . GLU A 1 18  ? 172.481 85.049  124.175 1 158.362 ? 456 GLU A OE1 1 
ATOM 143  O OE2 . GLU A 1 18  ? 172.877 87.07   124.951 1 157.084 ? 456 GLU A OE2 1 
ATOM 144  N N   . LYS A 1 19  ? 168.455 85.149  122.269 1 138.781 ? 457 LYS A N   1 
ATOM 145  C CA  . LYS A 1 19  ? 168.646 85.307  120.838 1 138.508 ? 457 LYS A CA  1 
ATOM 146  C C   . LYS A 1 19  ? 167.302 85.125  120.139 1 137.148 ? 457 LYS A C   1 
ATOM 147  O O   . LYS A 1 19  ? 167.058 84.054  119.594 1 136.664 ? 457 LYS A O   1 
ATOM 148  C CB  . LYS A 1 19  ? 169.567 84.194  120.327 1 140.454 ? 457 LYS A CB  1 
ATOM 149  C CG  . LYS A 1 19  ? 170.405 84.51   119.087 1 141.625 ? 457 LYS A CG  1 
ATOM 150  C CD  . LYS A 1 19  ? 170.249 83.512  117.942 1 142.761 ? 457 LYS A CD  1 
ATOM 151  C CE  . LYS A 1 19  ? 169.846 82.133  118.385 1 143.454 ? 457 LYS A CE  1 
ATOM 152  N NZ  . LYS A 1 19  ? 170.959 81.178  118.381 1 143.339 ? 457 LYS A NZ  1 
ATOM 153  N N   . GLY A 1 20  ? 166.43  86.144  120.152 1 131.957 ? 458 GLY A N   1 
ATOM 154  C CA  . GLY A 1 20  ? 165.074 86.003  119.629 1 128.95  ? 458 GLY A CA  1 
ATOM 155  C C   . GLY A 1 20  ? 164.911 86.679  118.267 1 124.384 ? 458 GLY A C   1 
ATOM 156  O O   . GLY A 1 20  ? 165.868 86.779  117.504 1 123.044 ? 458 GLY A O   1 
ATOM 157  N N   . ALA A 1 21  ? 163.694 87.151  117.96  1 119.608 ? 459 ALA A N   1 
ATOM 158  C CA  . ALA A 1 21  ? 163.486 87.988  116.785 1 116.005 ? 459 ALA A CA  1 
ATOM 159  C C   . ALA A 1 21  ? 164.473 89.148  116.851 1 111.579 ? 459 ALA A C   1 
ATOM 160  O O   . ALA A 1 21  ? 164.698 89.671  117.937 1 114.759 ? 459 ALA A O   1 
ATOM 161  C CB  . ALA A 1 21  ? 162.059 88.492  116.732 1 118.77  ? 459 ALA A CB  1 
ATOM 162  N N   . LYS A 1 22  ? 165.038 89.527  115.696 1 109.892 ? 460 LYS A N   1 
ATOM 163  C CA  . LYS A 1 22  ? 166.142 90.475  115.585 1 111.651 ? 460 LYS A CA  1 
ATOM 164  C C   . LYS A 1 22  ? 167.359 89.711  115.062 1 113.952 ? 460 LYS A C   1 
ATOM 165  O O   . LYS A 1 22  ? 168.257 90.308  114.471 1 116.606 ? 460 LYS A O   1 
ATOM 166  C CB  . LYS A 1 22  ? 166.533 91.247  116.856 1 113.37  ? 460 LYS A CB  1 
ATOM 167  C CG  . LYS A 1 22  ? 167.16  92.608  116.602 1 119.142 ? 460 LYS A CG  1 
ATOM 168  C CD  . LYS A 1 22  ? 167.949 93.153  117.785 1 123.934 ? 460 LYS A CD  1 
ATOM 169  C CE  . LYS A 1 22  ? 169.251 93.747  117.349 1 127.477 ? 460 LYS A CE  1 
ATOM 170  N NZ  . LYS A 1 22  ? 169.148 94.491  116.089 1 129.227 ? 460 LYS A NZ  1 
ATOM 171  N N   . PHE A 1 23  ? 167.387 88.392  115.286 1 112.261 ? 461 PHE A N   1 
ATOM 172  C CA  . PHE A 1 23  ? 168.383 87.54   114.658 1 115.37  ? 461 PHE A CA  1 
ATOM 173  C C   . PHE A 1 23  ? 167.769 86.913  113.412 1 110.721 ? 461 PHE A C   1 
ATOM 174  O O   . PHE A 1 23  ? 168.475 86.337  112.587 1 115.055 ? 461 PHE A O   1 
ATOM 175  C CB  . PHE A 1 23  ? 168.896 86.509  115.665 1 119.497 ? 461 PHE A CB  1 
ATOM 176  C CG  . PHE A 1 23  ? 169.659 87.144  116.817 1 125.003 ? 461 PHE A CG  1 
ATOM 177  C CD1 . PHE A 1 23  ? 171.036 87.317  116.744 1 127.677 ? 461 PHE A CD1 1 
ATOM 178  C CD2 . PHE A 1 23  ? 168.999 87.567  117.968 1 128.755 ? 461 PHE A CD2 1 
ATOM 179  C CE1 . PHE A 1 23  ? 171.732 87.897  117.793 1 130.009 ? 461 PHE A CE1 1 
ATOM 180  C CE2 . PHE A 1 23  ? 169.699 88.158  119.009 1 132.163 ? 461 PHE A CE2 1 
ATOM 181  C CZ  . PHE A 1 23  ? 171.064 88.315  118.923 1 132.723 ? 461 PHE A CZ  1 
ATOM 182  N N   . LEU A 1 24  ? 166.448 87.068  113.271 1 102.959 ? 462 LEU A N   1 
ATOM 183  C CA  . LEU A 1 24  ? 165.746 86.593  112.092 1 98.149  ? 462 LEU A CA  1 
ATOM 184  C C   . LEU A 1 24  ? 165.56  87.761  111.125 1 93.43   ? 462 LEU A C   1 
ATOM 185  O O   . LEU A 1 24  ? 165.475 88.915  111.544 1 96.394  ? 462 LEU A O   1 
ATOM 186  C CB  . LEU A 1 24  ? 164.42  85.959  112.513 1 97.181  ? 462 LEU A CB  1 
ATOM 187  C CG  . LEU A 1 24  ? 164.536 84.779  113.486 1 99.8    ? 462 LEU A CG  1 
ATOM 188  C CD1 . LEU A 1 24  ? 163.281 84.63   114.328 1 100.532 ? 462 LEU A CD1 1 
ATOM 189  C CD2 . LEU A 1 24  ? 164.83  83.475  112.757 1 102.193 ? 462 LEU A CD2 1 
ATOM 190  N N   . SER A 1 25  ? 165.547 87.45   109.824 1 91.827  ? 463 SER A N   1 
ATOM 191  C CA  . SER A 1 25  ? 165.356 88.456  108.79  1 89.587  ? 463 SER A CA  1 
ATOM 192  C C   . SER A 1 25  ? 163.864 88.654  108.55  1 89.18   ? 463 SER A C   1 
ATOM 193  O O   . SER A 1 25  ? 163.058 87.843  109     1 85.113  ? 463 SER A O   1 
ATOM 194  C CB  . SER A 1 25  ? 166.035 88.058  107.513 1 88.666  ? 463 SER A CB  1 
ATOM 195  O OG  . SER A 1 25  ? 165.17  87.271  106.706 1 86.786  ? 463 SER A OG  1 
ATOM 196  N N   . ASP A 1 26  ? 163.506 89.689  107.782 1 89.358  ? 464 ASP A N   1 
ATOM 197  C CA  . ASP A 1 26  ? 162.119 89.855  107.381 1 92.228  ? 464 ASP A CA  1 
ATOM 198  C C   . ASP A 1 26  ? 161.67  88.627  106.595 1 91.284  ? 464 ASP A C   1 
ATOM 199  O O   . ASP A 1 26  ? 160.55  88.178  106.798 1 86.431  ? 464 ASP A O   1 
ATOM 200  C CB  . ASP A 1 26  ? 161.856 91.179  106.678 1 92.9    ? 464 ASP A CB  1 
ATOM 201  C CG  . ASP A 1 26  ? 161.867 92.389  107.598 1 95.3    ? 464 ASP A CG  1 
ATOM 202  O OD1 . ASP A 1 26  ? 161.701 93.515  107.079 1 96.991  ? 464 ASP A OD1 1 
ATOM 203  O OD2 . ASP A 1 26  ? 162.04  92.195  108.826 1 92.719  ? 464 ASP A OD2 1 
ATOM 204  N N   . ALA A 1 27  ? 162.541 88.048  105.756 1 92.724  ? 465 ALA A N   1 
ATOM 205  C CA  . ALA A 1 27  ? 162.129 86.9    104.96  1 92.273  ? 465 ALA A CA  1 
ATOM 206  C C   . ALA A 1 27  ? 161.872 85.691  105.86  1 95.466  ? 465 ALA A C   1 
ATOM 207  O O   . ALA A 1 27  ? 160.94  84.93   105.608 1 93.19   ? 465 ALA A O   1 
ATOM 208  C CB  . ALA A 1 27  ? 163.156 86.588  103.897 1 95.537  ? 465 ALA A CB  1 
ATOM 209  N N   . GLU A 1 28  ? 162.691 85.528  106.907 1 97.251  ? 466 GLU A N   1 
ATOM 210  C CA  . GLU A 1 28  ? 162.569 84.394  107.812 1 98.669  ? 466 GLU A CA  1 
ATOM 211  C C   . GLU A 1 28  ? 161.26  84.495  108.596 1 94.254  ? 466 GLU A C   1 
ATOM 212  O O   . GLU A 1 28  ? 160.551 83.502  108.759 1 91.256  ? 466 GLU A O   1 
ATOM 213  C CB  . GLU A 1 28  ? 163.777 84.304  108.747 1 102.836 ? 466 GLU A CB  1 
ATOM 214  C CG  . GLU A 1 28  ? 165.109 84.446  108.012 1 109.382 ? 466 GLU A CG  1 
ATOM 215  C CD  . GLU A 1 28  ? 166.294 83.734  108.647 1 114.122 ? 466 GLU A CD  1 
ATOM 216  O OE1 . GLU A 1 28  ? 167.393 83.762  108.051 1 118.14  ? 466 GLU A OE1 1 
ATOM 217  O OE2 . GLU A 1 28  ? 166.128 83.122  109.719 1 114.478 ? 466 GLU A OE2 1 
ATOM 218  N N   . ILE A 1 29  ? 160.946 85.7    109.087 1 90.94   ? 467 ILE A N   1 
ATOM 219  C CA  . ILE A 1 29  ? 159.696 85.929  109.796 1 89.715  ? 467 ILE A CA  1 
ATOM 220  C C   . ILE A 1 29  ? 158.525 85.68   108.846 1 89.513  ? 467 ILE A C   1 
ATOM 221  O O   . ILE A 1 29  ? 157.523 85.091  109.242 1 86.914  ? 467 ILE A O   1 
ATOM 222  C CB  . ILE A 1 29  ? 159.636 87.346  110.394 1 93.21   ? 467 ILE A CB  1 
ATOM 223  C CG1 . ILE A 1 29  ? 160.872 87.672  111.241 1 95.501  ? 467 ILE A CG1 1 
ATOM 224  C CG2 . ILE A 1 29  ? 158.34  87.543  111.184 1 92.244  ? 467 ILE A CG2 1 
ATOM 225  C CD1 . ILE A 1 29  ? 161.046 86.787  112.46  1 97.627  ? 467 ILE A CD1 1 
ATOM 226  N N   . ILE A 1 30  ? 158.649 86.139  107.596 1 92.23   ? 468 ILE A N   1 
ATOM 227  C CA  . ILE A 1 30  ? 157.61  85.934  106.599 1 95.121  ? 468 ILE A CA  1 
ATOM 228  C C   . ILE A 1 30  ? 157.361 84.437  106.433 1 98.681  ? 468 ILE A C   1 
ATOM 229  O O   . ILE A 1 30  ? 156.212 84.007  106.4   1 97.034  ? 468 ILE A O   1 
ATOM 230  C CB  . ILE A 1 30  ? 157.997 86.612  105.271 1 100.904 ? 468 ILE A CB  1 
ATOM 231  C CG1 . ILE A 1 30  ? 157.691 88.106  105.3   1 100.23  ? 468 ILE A CG1 1 
ATOM 232  C CG2 . ILE A 1 30  ? 157.336 85.933  104.071 1 105.845 ? 468 ILE A CG2 1 
ATOM 233  C CD1 . ILE A 1 30  ? 158.568 88.918  104.365 1 103.079 ? 468 ILE A CD1 1 
ATOM 234  N N   . GLN A 1 31  ? 158.445 83.66   106.326 1 100.542 ? 469 GLN A N   1 
ATOM 235  C CA  . GLN A 1 31  ? 158.347 82.22   106.142 1 103.747 ? 469 GLN A CA  1 
ATOM 236  C C   . GLN A 1 31  ? 157.613 81.603  107.332 1 101.229 ? 469 GLN A C   1 
ATOM 237  O O   . GLN A 1 31  ? 156.74  80.755  107.154 1 98.338  ? 469 GLN A O   1 
ATOM 238  C CB  . GLN A 1 31  ? 159.745 81.628  105.963 1 110.286 ? 469 GLN A CB  1 
ATOM 239  C CG  . GLN A 1 31  ? 159.809 80.461  104.986 1 116.117 ? 469 GLN A CG  1 
ATOM 240  C CD  . GLN A 1 31  ? 161.205 80.242  104.446 1 123.258 ? 469 GLN A CD  1 
ATOM 241  O OE1 . GLN A 1 31  ? 162.171 80.106  105.205 1 124.48  ? 469 GLN A OE1 1 
ATOM 242  N NE2 . GLN A 1 31  ? 161.335 80.231  103.126 1 126.969 ? 469 GLN A NE2 1 
ATOM 243  N N   . LEU A 1 32  ? 157.95  82.058  108.544 1 100.284 ? 470 LEU A N   1 
ATOM 244  C CA  . LEU A 1 32  ? 157.373 81.497  109.755 1 101.619 ? 470 LEU A CA  1 
ATOM 245  C C   . LEU A 1 32  ? 155.881 81.791  109.806 1 100.14  ? 470 LEU A C   1 
ATOM 246  O O   . LEU A 1 32  ? 155.078 80.945  110.195 1 100.163 ? 470 LEU A O   1 
ATOM 247  C CB  . LEU A 1 32  ? 158.082 82.059  110.984 1 103.114 ? 470 LEU A CB  1 
ATOM 248  C CG  . LEU A 1 32  ? 159.376 81.354  111.391 1 105.31  ? 470 LEU A CG  1 
ATOM 249  C CD1 . LEU A 1 32  ? 159.718 81.663  112.842 1 107.067 ? 470 LEU A CD1 1 
ATOM 250  C CD2 . LEU A 1 32  ? 159.248 79.857  111.185 1 106.934 ? 470 LEU A CD2 1 
ATOM 251  N N   . VAL A 1 33  ? 155.517 83.008  109.404 1 100.024 ? 471 VAL A N   1 
ATOM 252  C CA  . VAL A 1 33  ? 154.122 83.403  109.428 1 97.969  ? 471 VAL A CA  1 
ATOM 253  C C   . VAL A 1 33  ? 153.344 82.581  108.401 1 98.124  ? 471 VAL A C   1 
ATOM 254  O O   . VAL A 1 33  ? 152.267 82.076  108.709 1 97.293  ? 471 VAL A O   1 
ATOM 255  C CB  . VAL A 1 33  ? 153.937 84.915  109.214 1 96.842  ? 471 VAL A CB  1 
ATOM 256  C CG1 . VAL A 1 33  ? 152.463 85.28   109.109 1 94.353  ? 471 VAL A CG1 1 
ATOM 257  C CG2 . VAL A 1 33  ? 154.603 85.721  110.324 1 97.042  ? 471 VAL A CG2 1 
ATOM 258  N N   . ASN A 1 34  ? 153.903 82.417  107.197 1 100.759 ? 472 ASN A N   1 
ATOM 259  C CA  . ASN A 1 34  ? 153.22  81.688  106.138 1 103.904 ? 472 ASN A CA  1 
ATOM 260  C C   . ASN A 1 34  ? 153.057 80.206  106.478 1 107.831 ? 472 ASN A C   1 
ATOM 261  O O   . ASN A 1 34  ? 152.147 79.557  105.97  1 106.388 ? 472 ASN A O   1 
ATOM 262  C CB  . ASN A 1 34  ? 153.932 81.825  104.798 1 105.24  ? 472 ASN A CB  1 
ATOM 263  C CG  . ASN A 1 34  ? 153.919 83.244  104.282 1 106.381 ? 472 ASN A CG  1 
ATOM 264  O OD1 . ASN A 1 34  ? 154.98  83.816  104.012 1 109.257 ? 472 ASN A OD1 1 
ATOM 265  N ND2 . ASN A 1 34  ? 152.738 83.826  104.128 1 102.688 ? 472 ASN A ND2 1 
ATOM 266  N N   . ALA A 1 35  ? 153.917 79.646  107.332 1 110.529 ? 473 ALA A N   1 
ATOM 267  C CA  . ALA A 1 35  ? 153.722 78.249  107.689 1 113.9   ? 473 ALA A CA  1 
ATOM 268  C C   . ALA A 1 35  ? 152.647 78.125  108.767 1 113.829 ? 473 ALA A C   1 
ATOM 269  O O   . ALA A 1 35  ? 152.354 77.017  109.211 1 115.468 ? 473 ALA A O   1 
ATOM 270  C CB  . ALA A 1 35  ? 155.021 77.627  108.121 1 117.722 ? 473 ALA A CB  1 
ATOM 271  N N   . LYS A 1 36  ? 152.073 79.267  109.178 1 110.855 ? 474 LYS A N   1 
ATOM 272  C CA  . LYS A 1 36  ? 151.023 79.32   110.185 1 112.183 ? 474 LYS A CA  1 
ATOM 273  C C   . LYS A 1 36  ? 151.594 78.987  111.563 1 110.826 ? 474 LYS A C   1 
ATOM 274  O O   . LYS A 1 36  ? 150.862 78.549  112.45  1 111.429 ? 474 LYS A O   1 
ATOM 275  C CB  . LYS A 1 36  ? 149.869 78.394  109.782 1 114.033 ? 474 LYS A CB  1 
ATOM 276  C CG  . LYS A 1 36  ? 149.304 78.692  108.415 1 119.265 ? 474 LYS A CG  1 
ATOM 277  C CD  . LYS A 1 36  ? 147.902 79.283  108.446 1 125.013 ? 474 LYS A CD  1 
ATOM 278  C CE  . LYS A 1 36  ? 147.074 78.727  107.335 1 129.564 ? 474 LYS A CE  1 
ATOM 279  N NZ  . LYS A 1 36  ? 147.323 77.292  107.148 1 131.042 ? 474 LYS A NZ  1 
ATOM 280  N N   . HIS A 1 37  ? 152.903 79.203  111.741 1 110.092 ? 475 HIS A N   1 
ATOM 281  C CA  . HIS A 1 37  ? 153.513 79.036  113.048 1 112.777 ? 475 HIS A CA  1 
ATOM 282  C C   . HIS A 1 37  ? 153.191 80.278  113.873 1 112.637 ? 475 HIS A C   1 
ATOM 283  O O   . HIS A 1 37  ? 152.504 80.179  114.885 1 117.498 ? 475 HIS A O   1 
ATOM 284  C CB  . HIS A 1 37  ? 155.017 78.756  112.946 1 113.954 ? 475 HIS A CB  1 
ATOM 285  C CG  . HIS A 1 37  ? 155.371 77.601  112.072 1 119.108 ? 475 HIS A CG  1 
ATOM 286  N ND1 . HIS A 1 37  ? 154.603 76.463  111.942 1 122.187 ? 475 HIS A ND1 1 
ATOM 287  C CD2 . HIS A 1 37  ? 156.428 77.427  111.27  1 121.204 ? 475 HIS A CD2 1 
ATOM 288  C CE1 . HIS A 1 37  ? 155.19  75.636  111.088 1 125.347 ? 475 HIS A CE1 1 
ATOM 289  N NE2 . HIS A 1 37  ? 156.302 76.201  110.671 1 123.656 ? 475 HIS A NE2 1 
ATOM 290  N N   . ILE A 1 38  ? 153.648 81.447  113.406 1 108.287 ? 476 ILE A N   1 
ATOM 291  C CA  . ILE A 1 38  ? 153.379 82.708  114.083 1 105.286 ? 476 ILE A CA  1 
ATOM 292  C C   . ILE A 1 38  ? 151.973 83.177  113.715 1 105.156 ? 476 ILE A C   1 
ATOM 293  O O   . ILE A 1 38  ? 151.603 83.153  112.545 1 105.928 ? 476 ILE A O   1 
ATOM 294  C CB  . ILE A 1 38  ? 154.412 83.787  113.71  1 105.033 ? 476 ILE A CB  1 
ATOM 295  C CG1 . ILE A 1 38  ? 155.843 83.261  113.782 1 107.62  ? 476 ILE A CG1 1 
ATOM 296  C CG2 . ILE A 1 38  ? 154.22  85.037  114.573 1 106.943 ? 476 ILE A CG2 1 
ATOM 297  C CD1 . ILE A 1 38  ? 156.908 84.308  113.5   1 107.198 ? 476 ILE A CD1 1 
ATOM 298  N N   . PRO A 1 39  ? 151.141 83.636  114.678 1 102.525 ? 477 PRO A N   1 
ATOM 299  C CA  . PRO A 1 39  ? 149.888 84.285  114.33  1 100.936 ? 477 PRO A CA  1 
ATOM 300  C C   . PRO A 1 39  ? 150.133 85.751  114     1 99.34   ? 477 PRO A C   1 
ATOM 301  O O   . PRO A 1 39  ? 150.623 86.494  114.843 1 96.9    ? 477 PRO A O   1 
ATOM 302  C CB  . PRO A 1 39  ? 149.032 84.062  115.57  1 101.049 ? 477 PRO A CB  1 
ATOM 303  C CG  . PRO A 1 39  ? 150.046 84.037  116.705 1 103.088 ? 477 PRO A CG  1 
ATOM 304  C CD  . PRO A 1 39  ? 151.361 83.571  116.131 1 101.972 ? 477 PRO A CD  1 
ATOM 305  N N   . ALA A 1 40  ? 149.828 86.154  112.766 1 97.325  ? 478 ALA A N   1 
ATOM 306  C CA  . ALA A 1 40  ? 150.171 87.493  112.308 1 97.958  ? 478 ALA A CA  1 
ATOM 307  C C   . ALA A 1 40  ? 149.652 88.567  113.265 1 98.679  ? 478 ALA A C   1 
ATOM 308  O O   . ALA A 1 40  ? 150.278 89.613  113.411 1 94.353  ? 478 ALA A O   1 
ATOM 309  C CB  . ALA A 1 40  ? 149.657 87.726  110.909 1 97.197  ? 478 ALA A CB  1 
ATOM 310  N N   . TYR A 1 41  ? 148.533 88.305  113.947 1 99.833  ? 479 TYR A N   1 
ATOM 311  C CA  . TYR A 1 41  ? 147.947 89.305  114.827 1 102.356 ? 479 TYR A CA  1 
ATOM 312  C C   . TYR A 1 41  ? 148.846 89.569  116.038 1 99.475  ? 479 TYR A C   1 
ATOM 313  O O   . TYR A 1 41  ? 148.669 90.582  116.714 1 101.359 ? 479 TYR A O   1 
ATOM 314  C CB  . TYR A 1 41  ? 146.543 88.89   115.277 1 111.248 ? 479 TYR A CB  1 
ATOM 315  C CG  . TYR A 1 41  ? 146.515 87.824  116.364 1 119.775 ? 479 TYR A CG  1 
ATOM 316  C CD1 . TYR A 1 41  ? 146.671 88.16   117.705 1 126.963 ? 479 TYR A CD1 1 
ATOM 317  C CD2 . TYR A 1 41  ? 146.344 86.484  116.045 1 124.978 ? 479 TYR A CD2 1 
ATOM 318  C CE1 . TYR A 1 41  ? 146.665 87.191  118.696 1 132.538 ? 479 TYR A CE1 1 
ATOM 319  C CE2 . TYR A 1 41  ? 146.316 85.508  117.029 1 128.612 ? 479 TYR A CE2 1 
ATOM 320  C CZ  . TYR A 1 41  ? 146.48  85.862  118.357 1 132.233 ? 479 TYR A CZ  1 
ATOM 321  O OH  . TYR A 1 41  ? 146.461 84.905  119.331 1 134.16  ? 479 TYR A OH  1 
ATOM 322  N N   . LYS A 1 42  ? 149.806 88.672  116.306 1 97.654  ? 480 LYS A N   1 
ATOM 323  C CA  . LYS A 1 42  ? 150.673 88.786  117.471 1 100.387 ? 480 LYS A CA  1 
ATOM 324  C C   . LYS A 1 42  ? 152.02  89.406  117.098 1 95.287  ? 480 LYS A C   1 
ATOM 325  O O   . LYS A 1 42  ? 152.92  89.448  117.937 1 97.75   ? 480 LYS A O   1 
ATOM 326  C CB  . LYS A 1 42  ? 150.881 87.386  118.059 1 109.717 ? 480 LYS A CB  1 
ATOM 327  C CG  . LYS A 1 42  ? 150.602 87.234  119.541 1 118.122 ? 480 LYS A CG  1 
ATOM 328  C CD  . LYS A 1 42  ? 150.686 85.776  119.974 1 123.28  ? 480 LYS A CD  1 
ATOM 329  C CE  . LYS A 1 42  ? 150.464 85.58   121.443 1 126.577 ? 480 LYS A CE  1 
ATOM 330  N NZ  . LYS A 1 42  ? 151.528 86.179  122.255 1 128.31  ? 480 LYS A NZ  1 
ATOM 331  N N   . LEU A 1 43  ? 152.129 89.948  115.877 1 85.673  ? 481 LEU A N   1 
ATOM 332  C CA  . LEU A 1 43  ? 153.397 90.415  115.341 1 82.933  ? 481 LEU A CA  1 
ATOM 333  C C   . LEU A 1 43  ? 154.006 91.518  116.206 1 81.069  ? 481 LEU A C   1 
ATOM 334  O O   . LEU A 1 43  ? 155.204 91.495  116.488 1 83.413  ? 481 LEU A O   1 
ATOM 335  C CB  . LEU A 1 43  ? 153.163 90.864  113.899 1 79.679  ? 481 LEU A CB  1 
ATOM 336  C CG  . LEU A 1 43  ? 153.379 89.785  112.833 1 80.484  ? 481 LEU A CG  1 
ATOM 337  C CD1 . LEU A 1 43  ? 152.936 90.26   111.45  1 81.406  ? 481 LEU A CD1 1 
ATOM 338  C CD2 . LEU A 1 43  ? 154.841 89.348  112.809 1 80.079  ? 481 LEU A CD2 1 
ATOM 339  N N   . GLU A 1 44  ? 153.182 92.47   116.654 1 82.029  ? 482 GLU A N   1 
ATOM 340  C CA  . GLU A 1 44  ? 153.688 93.614  117.4   1 85.277  ? 482 GLU A CA  1 
ATOM 341  C C   . GLU A 1 44  ? 154.209 93.155  118.768 1 85.933  ? 482 GLU A C   1 
ATOM 342  O O   . GLU A 1 44  ? 155.149 93.738  119.301 1 84.092  ? 482 GLU A O   1 
ATOM 343  C CB  . GLU A 1 44  ? 152.638 94.725  117.45  1 92.355  ? 482 GLU A CB  1 
ATOM 344  C CG  . GLU A 1 44  ? 151.935 94.962  116.113 1 100.623 ? 482 GLU A CG  1 
ATOM 345  C CD  . GLU A 1 44  ? 151.865 96.406  115.645 1 114.317 ? 482 GLU A CD  1 
ATOM 346  O OE1 . GLU A 1 44  ? 151.163 96.706  114.636 1 122.051 ? 482 GLU A OE1 1 
ATOM 347  O OE2 . GLU A 1 44  ? 152.554 97.241  116.269 1 121.042 ? 482 GLU A OE2 1 
ATOM 348  N N   . THR A 1 45  ? 153.649 92.063  119.304 1 88.687  ? 483 THR A N   1 
ATOM 349  C CA  . THR A 1 45  ? 154.127 91.472  120.546 1 93.533  ? 483 THR A CA  1 
ATOM 350  C C   . THR A 1 45  ? 155.285 90.521  120.235 1 95.074  ? 483 THR A C   1 
ATOM 351  O O   . THR A 1 45  ? 156.318 90.578  120.898 1 100.157 ? 483 THR A O   1 
ATOM 352  C CB  . THR A 1 45  ? 152.982 90.76   121.27  1 94.915  ? 483 THR A CB  1 
ATOM 353  O OG1 . THR A 1 45  ? 152.963 89.392  120.874 1 96.107  ? 483 THR A OG1 1 
ATOM 354  C CG2 . THR A 1 45  ? 151.624 91.372  120.979 1 99.611  ? 483 THR A CG2 1 
ATOM 355  N N   . LEU A 1 46  ? 155.118 89.68   119.206 1 93.633  ? 484 LEU A N   1 
ATOM 356  C CA  . LEU A 1 46  ? 156.089 88.656  118.844 1 95.063  ? 484 LEU A CA  1 
ATOM 357  C C   . LEU A 1 46  ? 157.407 89.252  118.353 1 92.05   ? 484 LEU A C   1 
ATOM 358  O O   . LEU A 1 46  ? 158.455 88.654  118.582 1 97.304  ? 484 LEU A O   1 
ATOM 359  C CB  . LEU A 1 46  ? 155.482 87.727  117.792 1 99.813  ? 484 LEU A CB  1 
ATOM 360  C CG  . LEU A 1 46  ? 154.87  86.416  118.3   1 107.314 ? 484 LEU A CG  1 
ATOM 361  C CD1 . LEU A 1 46  ? 155.827 85.254  118.045 1 112.457 ? 484 LEU A CD1 1 
ATOM 362  C CD2 . LEU A 1 46  ? 154.509 86.46   119.778 1 108.848 ? 484 LEU A CD2 1 
ATOM 363  N N   . MET A 1 47  ? 157.356 90.399  117.666 1 91.804  ? 485 MET A N   1 
ATOM 364  C CA  . MET A 1 47  ? 158.555 90.984  117.085 1 90.203  ? 485 MET A CA  1 
ATOM 365  C C   . MET A 1 47  ? 159.368 91.667  118.177 1 89.64   ? 485 MET A C   1 
ATOM 366  O O   . MET A 1 47  ? 158.94  91.729  119.325 1 92.657  ? 485 MET A O   1 
ATOM 367  C CB  . MET A 1 47  ? 158.231 91.995  115.975 1 89.171  ? 485 MET A CB  1 
ATOM 368  C CG  . MET A 1 47  ? 157.977 91.373  114.615 1 88.787  ? 485 MET A CG  1 
ATOM 369  S SD  . MET A 1 47  ? 159.068 89.994  114.206 1 89.771  ? 485 MET A SD  1 
ATOM 370  C CE  . MET A 1 47  ? 158.014 88.596  114.624 1 88.034  ? 485 MET A CE  1 
ATOM 371  N N   . GLU A 1 48  ? 160.547 92.162  117.802 1 93.06   ? 486 GLU A N   1 
ATOM 372  C CA  . GLU A 1 48  ? 161.45  92.797  118.747 1 97.761  ? 486 GLU A CA  1 
ATOM 373  C C   . GLU A 1 48  ? 160.841 94.123  119.176 1 96.304  ? 486 GLU A C   1 
ATOM 374  O O   . GLU A 1 48  ? 160.567 94.341  120.355 1 99.129  ? 486 GLU A O   1 
ATOM 375  C CB  . GLU A 1 48  ? 162.801 93.141  118.129 1 99.302  ? 486 GLU A CB  1 
ATOM 376  C CG  . GLU A 1 48  ? 162.93  92.629  116.702 1 102.659 ? 486 GLU A CG  1 
ATOM 377  C CD  . GLU A 1 48  ? 163.716 93.546  115.795 1 108.815 ? 486 GLU A CD  1 
ATOM 378  O OE1 . GLU A 1 48  ? 164.192 93.043  114.753 1 112.446 ? 486 GLU A OE1 1 
ATOM 379  O OE2 . GLU A 1 48  ? 163.833 94.75   116.106 1 109.508 ? 486 GLU A OE2 1 
ATOM 380  N N   . THR A 1 49  ? 160.668 95.022  118.202 1 95.177  ? 487 THR A N   1 
ATOM 381  C CA  . THR A 1 49  ? 159.973 96.268  118.471 1 92.624  ? 487 THR A CA  1 
ATOM 382  C C   . THR A 1 49  ? 158.606 96.179  117.806 1 89.654  ? 487 THR A C   1 
ATOM 383  O O   . THR A 1 49  ? 158.408 95.398  116.875 1 88.314  ? 487 THR A O   1 
ATOM 384  C CB  . THR A 1 49  ? 160.753 97.489  117.979 1 94.288  ? 487 THR A CB  1 
ATOM 385  O OG1 . THR A 1 49  ? 160.141 97.876  116.751 1 90.511  ? 487 THR A OG1 1 
ATOM 386  C CG2 . THR A 1 49  ? 162.247 97.238  117.841 1 98.786  ? 487 THR A CG2 1 
ATOM 387  N N   . HIS A 1 50  ? 157.683 97.019  118.271 1 86.816  ? 488 HIS A N   1 
ATOM 388  C CA  . HIS A 1 50  ? 156.337 97.051  117.72  1 85.523  ? 488 HIS A CA  1 
ATOM 389  C C   . HIS A 1 50  ? 156.369 97.517  116.266 1 78.686  ? 488 HIS A C   1 
ATOM 390  O O   . HIS A 1 50  ? 155.668 96.973  115.416 1 71.966  ? 488 HIS A O   1 
ATOM 391  C CB  . HIS A 1 50  ? 155.432 97.951  118.567 1 89.808  ? 488 HIS A CB  1 
ATOM 392  C CG  . HIS A 1 50  ? 155.484 97.622  120.021 1 98.949  ? 488 HIS A CG  1 
ATOM 393  N ND1 . HIS A 1 50  ? 155.396 96.337  120.512 1 101.844 ? 488 HIS A ND1 1 
ATOM 394  C CD2 . HIS A 1 50  ? 155.624 98.419  121.087 1 104.842 ? 488 HIS A CD2 1 
ATOM 395  C CE1 . HIS A 1 50  ? 155.487 96.369  121.835 1 109.726 ? 488 HIS A CE1 1 
ATOM 396  N NE2 . HIS A 1 50  ? 155.62  97.626  122.207 1 108.622 ? 488 HIS A NE2 1 
ATOM 397  N N   . GLU A 1 51  ? 157.216 98.514  115.994 1 77.424  ? 489 GLU A N   1 
ATOM 398  C CA  . GLU A 1 51  ? 157.358 99.061  114.658 1 74.567  ? 489 GLU A CA  1 
ATOM 399  C C   . GLU A 1 51  ? 157.697 97.941  113.677 1 74.93   ? 489 GLU A C   1 
ATOM 400  O O   . GLU A 1 51  ? 157.171 97.918  112.565 1 74.348  ? 489 GLU A O   1 
ATOM 401  C CB  . GLU A 1 51  ? 158.438 100.139 114.679 1 79.039  ? 489 GLU A CB  1 
ATOM 402  C CG  . GLU A 1 51  ? 158.546 100.933 113.383 1 81.533  ? 489 GLU A CG  1 
ATOM 403  C CD  . GLU A 1 51  ? 159.596 102.025 113.466 1 91.398  ? 489 GLU A CD  1 
ATOM 404  O OE1 . GLU A 1 51  ? 160.218 102.192 114.541 1 99.977  ? 489 GLU A OE1 1 
ATOM 405  O OE2 . GLU A 1 51  ? 159.794 102.718 112.454 1 90.498  ? 489 GLU A OE2 1 
ATOM 406  N N   . ARG A 1 52  ? 158.584 97.021  114.072 1 72.026  ? 490 ARG A N   1 
ATOM 407  C CA  . ARG A 1 52  ? 158.952 95.956  113.159 1 71.76   ? 490 ARG A CA  1 
ATOM 408  C C   . ARG A 1 52  ? 157.703 95.132  112.881 1 68.243  ? 490 ARG A C   1 
ATOM 409  O O   . ARG A 1 52  ? 157.374 94.846  111.733 1 66.281  ? 490 ARG A O   1 
ATOM 410  C CB  . ARG A 1 52  ? 160.07  95.048  113.673 1 75.951  ? 490 ARG A CB  1 
ATOM 411  C CG  . ARG A 1 52  ? 160.349 93.892  112.723 1 80.446  ? 490 ARG A CG  1 
ATOM 412  C CD  . ARG A 1 52  ? 161.812 93.518  112.731 1 84.821  ? 490 ARG A CD  1 
ATOM 413  N NE  . ARG A 1 52  ? 162.119 92.51   111.711 1 89.134  ? 490 ARG A NE  1 
ATOM 414  C CZ  . ARG A 1 52  ? 162.643 91.312  111.953 1 90.446  ? 490 ARG A CZ  1 
ATOM 415  N NH1 . ARG A 1 52  ? 162.779 90.871  113.193 1 89.571  ? 490 ARG A NH1 1 
ATOM 416  N NH2 . ARG A 1 52  ? 163.003 90.539  110.944 1 89.997  ? 490 ARG A NH2 1 
ATOM 417  N N   . GLY A 1 53  ? 156.992 94.78   113.949 1 65.605  ? 491 GLY A N   1 
ATOM 418  C CA  . GLY A 1 53  ? 155.799 93.97   113.8   1 65.253  ? 491 GLY A CA  1 
ATOM 419  C C   . GLY A 1 53  ? 154.87  94.52   112.714 1 69.669  ? 491 GLY A C   1 
ATOM 420  O O   . GLY A 1 53  ? 154.426 93.796  111.828 1 67.422  ? 491 GLY A O   1 
ATOM 421  N N   . VAL A 1 54  ? 154.617 95.825  112.753 1 65.151  ? 492 VAL A N   1 
ATOM 422  C CA  . VAL A 1 54  ? 153.76  96.445  111.758 1 67.616  ? 492 VAL A CA  1 
ATOM 423  C C   . VAL A 1 54  ? 154.46  96.429  110.396 1 64.5    ? 492 VAL A C   1 
ATOM 424  O O   . VAL A 1 54  ? 153.791 96.306  109.372 1 58.77   ? 492 VAL A O   1 
ATOM 425  C CB  . VAL A 1 54  ? 153.297 97.858  112.168 1 68.596  ? 492 VAL A CB  1 
ATOM 426  C CG1 . VAL A 1 54  ? 154.042 98.376  113.389 1 81.036  ? 492 VAL A CG1 1 
ATOM 427  C CG2 . VAL A 1 54  ? 153.375 98.861  111.02  1 69.003  ? 492 VAL A CG2 1 
ATOM 428  N N   . SER A 1 55  ? 155.793 96.53   110.382 1 66.029  ? 493 SER A N   1 
ATOM 429  C CA  . SER A 1 55  ? 156.551 96.391  109.146 1 66.392  ? 493 SER A CA  1 
ATOM 430  C C   . SER A 1 55  ? 156.305 95.018  108.518 1 64.746  ? 493 SER A C   1 
ATOM 431  O O   . SER A 1 55  ? 156.072 94.916  107.313 1 66.399  ? 493 SER A O   1 
ATOM 432  C CB  . SER A 1 55  ? 158.024 96.638  109.377 1 68.203  ? 493 SER A CB  1 
ATOM 433  O OG  . SER A 1 55  ? 158.669 96.998  108.163 1 70.4    ? 493 SER A OG  1 
ATOM 434  N N   . ILE A 1 56  ? 156.392 93.959  109.331 1 65.72   ? 494 ILE A N   1 
ATOM 435  C CA  . ILE A 1 56  ? 156.195 92.608  108.839 1 68.953  ? 494 ILE A CA  1 
ATOM 436  C C   . ILE A 1 56  ? 154.779 92.485  108.283 1 69.821  ? 494 ILE A C   1 
ATOM 437  O O   . ILE A 1 56  ? 154.569 91.908  107.222 1 66.279  ? 494 ILE A O   1 
ATOM 438  C CB  . ILE A 1 56  ? 156.477 91.568  109.937 1 70.655  ? 494 ILE A CB  1 
ATOM 439  C CG1 . ILE A 1 56  ? 157.936 91.616  110.428 1 73.352  ? 494 ILE A CG1 1 
ATOM 440  C CG2 . ILE A 1 56  ? 156.094 90.169  109.46  1 71.901  ? 494 ILE A CG2 1 
ATOM 441  C CD1 . ILE A 1 56  ? 158.98  91.582  109.325 1 74.331  ? 494 ILE A CD1 1 
ATOM 442  N N   . ARG A 1 57  ? 153.797 93.008  109.018 1 65.654  ? 495 ARG A N   1 
ATOM 443  C CA  . ARG A 1 57  ? 152.41  92.945  108.583 1 62.089  ? 495 ARG A CA  1 
ATOM 444  C C   . ARG A 1 57  ? 152.247 93.653  107.237 1 61.035  ? 495 ARG A C   1 
ATOM 445  O O   . ARG A 1 57  ? 151.566 93.148  106.345 1 57.512  ? 495 ARG A O   1 
ATOM 446  C CB  . ARG A 1 57  ? 151.469 93.545  109.634 1 63.747  ? 495 ARG A CB  1 
ATOM 447  C CG  . ARG A 1 57  ? 150.003 93.254  109.336 1 64.756  ? 495 ARG A CG  1 
ATOM 448  C CD  . ARG A 1 57  ? 149.013 93.793  110.358 1 65.116  ? 495 ARG A CD  1 
ATOM 449  N NE  . ARG A 1 57  ? 149.095 93.08   111.639 1 64.679  ? 495 ARG A NE  1 
ATOM 450  C CZ  . ARG A 1 57  ? 149.743 93.49   112.722 1 62.006  ? 495 ARG A CZ  1 
ATOM 451  N NH1 . ARG A 1 57  ? 150.333 94.676  112.747 1 60.777  ? 495 ARG A NH1 1 
ATOM 452  N NH2 . ARG A 1 57  ? 149.872 92.671  113.759 1 65.856  ? 495 ARG A NH2 1 
ATOM 453  N N   . ARG A 1 58  ? 152.912 94.8    107.081 1 58.549  ? 496 ARG A N   1 
ATOM 454  C CA  . ARG A 1 58  ? 152.853 95.547  105.836 1 57.971  ? 496 ARG A CA  1 
ATOM 455  C C   . ARG A 1 58  ? 153.43  94.736  104.677 1 60.54   ? 496 ARG A C   1 
ATOM 456  O O   . ARG A 1 58  ? 152.845 94.741  103.601 1 59.498  ? 496 ARG A O   1 
ATOM 457  C CB  . ARG A 1 58  ? 153.606 96.871  105.954 1 55.841  ? 496 ARG A CB  1 
ATOM 458  C CG  . ARG A 1 58  ? 152.877 97.907  106.793 1 55.885  ? 496 ARG A CG  1 
ATOM 459  C CD  . ARG A 1 58  ? 153.78  99.077  107.062 1 53.776  ? 496 ARG A CD  1 
ATOM 460  N NE  . ARG A 1 58  ? 154.191 99.709  105.806 1 52.226  ? 496 ARG A NE  1 
ATOM 461  C CZ  . ARG A 1 58  ? 153.737 100.854 105.322 1 54.034  ? 496 ARG A CZ  1 
ATOM 462  N NH1 . ARG A 1 58  ? 152.784 101.528 105.935 1 56.227  ? 496 ARG A NH1 1 
ATOM 463  N NH2 . ARG A 1 58  ? 154.228 101.338 104.199 1 53.344  ? 496 ARG A NH2 1 
ATOM 464  N N   . GLN A 1 59  ? 154.572 94.068  104.886 1 62.622  ? 497 GLN A N   1 
ATOM 465  C CA  . GLN A 1 59  ? 155.201 93.285  103.83  1 63.169  ? 497 GLN A CA  1 
ATOM 466  C C   . GLN A 1 59  ? 154.264 92.151  103.417 1 61.397  ? 497 GLN A C   1 
ATOM 467  O O   . GLN A 1 59  ? 154.071 91.902  102.229 1 62.653  ? 497 GLN A O   1 
ATOM 468  C CB  . GLN A 1 59  ? 156.575 92.771  104.264 1 65.249  ? 497 GLN A CB  1 
ATOM 469  C CG  . GLN A 1 59  ? 157.672 93.822  104.175 1 71.453  ? 497 GLN A CG  1 
ATOM 470  C CD  . GLN A 1 59  ? 158.853 93.51   105.067 1 74.243  ? 497 GLN A CD  1 
ATOM 471  O OE1 . GLN A 1 59  ? 159.591 92.54   104.859 1 82.831  ? 497 GLN A OE1 1 
ATOM 472  N NE2 . GLN A 1 59  ? 159.052 94.347  106.07  1 74.132  ? 497 GLN A NE2 1 
ATOM 473  N N   . LEU A 1 60  ? 153.694 91.453  104.406 1 63.957  ? 498 LEU A N   1 
ATOM 474  C CA  . LEU A 1 60  ? 152.775 90.362  104.134 1 66.161  ? 498 LEU A CA  1 
ATOM 475  C C   . LEU A 1 60  ? 151.61  90.87   103.293 1 68.259  ? 498 LEU A C   1 
ATOM 476  O O   . LEU A 1 60  ? 151.25  90.254  102.294 1 68.809  ? 498 LEU A O   1 
ATOM 477  C CB  . LEU A 1 60  ? 152.279 89.736  105.434 1 69.643  ? 498 LEU A CB  1 
ATOM 478  C CG  . LEU A 1 60  ? 153.306 88.913  106.218 1 75.333  ? 498 LEU A CG  1 
ATOM 479  C CD1 . LEU A 1 60  ? 152.639 88.246  107.405 1 78.538  ? 498 LEU A CD1 1 
ATOM 480  C CD2 . LEU A 1 60  ? 154.009 87.87   105.361 1 78.516  ? 498 LEU A CD2 1 
ATOM 481  N N   . LEU A 1 61  ? 151.033 92.003  103.7   1 65.192  ? 499 LEU A N   1 
ATOM 482  C CA  . LEU A 1 61  ? 149.898 92.569  102.992 1 63.13   ? 499 LEU A CA  1 
ATOM 483  C C   . LEU A 1 61  ? 150.298 92.948  101.568 1 65.218  ? 499 LEU A C   1 
ATOM 484  O O   . LEU A 1 61  ? 149.56  92.68   100.626 1 66.402  ? 499 LEU A O   1 
ATOM 485  C CB  . LEU A 1 61  ? 149.355 93.778  103.75  1 63.013  ? 499 LEU A CB  1 
ATOM 486  C CG  . LEU A 1 61  ? 148.258 94.574  103.037 1 62.341  ? 499 LEU A CG  1 
ATOM 487  C CD1 . LEU A 1 61  ? 147.053 93.701  102.732 1 65.438  ? 499 LEU A CD1 1 
ATOM 488  C CD2 . LEU A 1 61  ? 147.824 95.772  103.838 1 62.902  ? 499 LEU A CD2 1 
ATOM 489  N N   . SER A 1 62  ? 151.468 93.572  101.412 1 70.698  ? 500 SER A N   1 
ATOM 490  C CA  . SER A 1 62  ? 151.927 93.998  100.101 1 72.662  ? 500 SER A CA  1 
ATOM 491  C C   . SER A 1 62  ? 151.995 92.814  99.143  1 72.723  ? 500 SER A C   1 
ATOM 492  O O   . SER A 1 62  ? 151.656 92.954  97.976  1 77.148  ? 500 SER A O   1 
ATOM 493  C CB  . SER A 1 62  ? 153.253 94.696  100.193 1 73.129  ? 500 SER A CB  1 
ATOM 494  O OG  . SER A 1 62  ? 153.069 96.026  100.652 1 70.597  ? 500 SER A OG  1 
ATOM 495  N N   . LYS A 1 63  ? 152.432 91.652  99.631  1 77.378  ? 501 LYS A N   1 
ATOM 496  C CA  . LYS A 1 63  ? 152.59  90.504  98.756  1 83.472  ? 501 LYS A CA  1 
ATOM 497  C C   . LYS A 1 63  ? 151.248 90.142  98.117  1 84.857  ? 501 LYS A C   1 
ATOM 498  O O   . LYS A 1 63  ? 151.22  89.635  96.998  1 92.137  ? 501 LYS A O   1 
ATOM 499  C CB  . LYS A 1 63  ? 153.21  89.331  99.522  1 88.545  ? 501 LYS A CB  1 
ATOM 500  C CG  . LYS A 1 63  ? 153.938 88.296  98.669  1 96.27   ? 501 LYS A CG  1 
ATOM 501  C CD  . LYS A 1 63  ? 154.886 88.879  97.628  1 102.235 ? 501 LYS A CD  1 
ATOM 502  C CE  . LYS A 1 63  ? 155.846 87.868  97.059  1 106.105 ? 501 LYS A CE  1 
ATOM 503  N NZ  . LYS A 1 63  ? 155.167 86.714  96.462  1 107.544 ? 501 LYS A NZ  1 
ATOM 504  N N   . LYS A 1 64  ? 150.137 90.411  98.816  1 82.397  ? 502 LYS A N   1 
ATOM 505  C CA  . LYS A 1 64  ? 148.82  89.977  98.366  1 82.668  ? 502 LYS A CA  1 
ATOM 506  C C   . LYS A 1 64  ? 148.086 91.05   97.558  1 79.272  ? 502 LYS A C   1 
ATOM 507  O O   . LYS A 1 64  ? 146.964 90.818  97.12   1 81.381  ? 502 LYS A O   1 
ATOM 508  C CB  . LYS A 1 64  ? 147.946 89.582  99.561  1 84.177  ? 502 LYS A CB  1 
ATOM 509  C CG  . LYS A 1 64  ? 148.377 88.304  100.252 1 90.476  ? 502 LYS A CG  1 
ATOM 510  C CD  . LYS A 1 64  ? 147.525 87.91   101.451 1 93.032  ? 502 LYS A CD  1 
ATOM 511  C CE  . LYS A 1 64  ? 147.527 88.937  102.536 1 95.499  ? 502 LYS A CE  1 
ATOM 512  N NZ  . LYS A 1 64  ? 147.336 88.323  103.853 1 97.155  ? 502 LYS A NZ  1 
ATOM 513  N N   . LEU A 1 65  ? 148.702 92.216  97.339  1 79.327  ? 503 LEU A N   1 
ATOM 514  C CA  . LEU A 1 65  ? 148.039 93.287  96.607  1 76.171  ? 503 LEU A CA  1 
ATOM 515  C C   . LEU A 1 65  ? 148.355 93.174  95.119  1 82.358  ? 503 LEU A C   1 
ATOM 516  O O   . LEU A 1 65  ? 149.411 92.68   94.725  1 89.081  ? 503 LEU A O   1 
ATOM 517  C CB  . LEU A 1 65  ? 148.471 94.651  97.138  1 75.44   ? 503 LEU A CB  1 
ATOM 518  C CG  . LEU A 1 65  ? 148.031 94.989  98.566  1 73.22   ? 503 LEU A CG  1 
ATOM 519  C CD1 . LEU A 1 65  ? 148.76  96.222  99.066  1 74.326  ? 503 LEU A CD1 1 
ATOM 520  C CD2 . LEU A 1 65  ? 146.53  95.189  98.672  1 71.994  ? 503 LEU A CD2 1 
ATOM 521  N N   . SER A 1 66  ? 147.429 93.676  94.297  1 82.743  ? 504 SER A N   1 
ATOM 522  C CA  . SER A 1 66  ? 147.603 93.679  92.853  1 89.506  ? 504 SER A CA  1 
ATOM 523  C C   . SER A 1 66  ? 148.674 94.693  92.455  1 88.884  ? 504 SER A C   1 
ATOM 524  O O   . SER A 1 66  ? 149.311 94.544  91.416  1 92.666  ? 504 SER A O   1 
ATOM 525  C CB  . SER A 1 66  ? 146.309 93.96   92.135  1 88.56   ? 504 SER A CB  1 
ATOM 526  O OG  . SER A 1 66  ? 146.115 95.357  91.965  1 90.058  ? 504 SER A OG  1 
ATOM 527  N N   . GLU A 1 67  ? 148.843 95.735  93.277  1 88.314  ? 505 GLU A N   1 
ATOM 528  C CA  . GLU A 1 67  ? 149.925 96.686  93.094  1 88.672  ? 505 GLU A CA  1 
ATOM 529  C C   . GLU A 1 67  ? 150.788 96.66   94.349  1 83.78   ? 505 GLU A C   1 
ATOM 530  O O   . GLU A 1 67  ? 150.497 97.364  95.309  1 80.992  ? 505 GLU A O   1 
ATOM 531  C CB  . GLU A 1 67  ? 149.372 98.078  92.787  1 90.414  ? 505 GLU A CB  1 
ATOM 532  C CG  . GLU A 1 67  ? 150.442 99.152  92.602  1 98.814  ? 505 GLU A CG  1 
ATOM 533  C CD  . GLU A 1 67  ? 151.698 98.698  91.877  1 104.103 ? 505 GLU A CD  1 
ATOM 534  O OE1 . GLU A 1 67  ? 151.936 99.161  90.739  1 109.539 ? 505 GLU A OE1 1 
ATOM 535  O OE2 . GLU A 1 67  ? 152.447 97.889  92.462  1 103.839 ? 505 GLU A OE2 1 
ATOM 536  N N   . PRO A 1 68  ? 151.873 95.851  94.379  1 85.111  ? 506 PRO A N   1 
ATOM 537  C CA  . PRO A 1 68  ? 152.69  95.702  95.58   1 82.273  ? 506 PRO A CA  1 
ATOM 538  C C   . PRO A 1 68  ? 153.177 97      96.221  1 72.565  ? 506 PRO A C   1 
ATOM 539  O O   . PRO A 1 68  ? 153.513 97.007  97.401  1 77.434  ? 506 PRO A O   1 
ATOM 540  C CB  . PRO A 1 68  ? 153.87  94.855  95.104  1 84.841  ? 506 PRO A CB  1 
ATOM 541  C CG  . PRO A 1 68  ? 153.264 94.041  93.977  1 86.803  ? 506 PRO A CG  1 
ATOM 542  C CD  . PRO A 1 68  ? 152.336 94.99   93.279  1 86.167  ? 506 PRO A CD  1 
ATOM 543  N N   . SER A 1 69  ? 153.235 98.088  95.447  1 67.845  ? 507 SER A N   1 
ATOM 544  C CA  . SER A 1 69  ? 153.793 99.345  95.923  1 68.073  ? 507 SER A CA  1 
ATOM 545  C C   . SER A 1 69  ? 152.726 100.266 96.529  1 65.478  ? 507 SER A C   1 
ATOM 546  O O   . SER A 1 69  ? 152.987 101.446 96.763  1 60.652  ? 507 SER A O   1 
ATOM 547  C CB  . SER A 1 69  ? 154.519 100.03  94.796  1 72.478  ? 507 SER A CB  1 
ATOM 548  O OG  . SER A 1 69  ? 154.925 101.34  95.164  1 77.824  ? 507 SER A OG  1 
ATOM 549  N N   . SER A 1 70  ? 151.525 99.744  96.797  1 61.304  ? 508 SER A N   1 
ATOM 550  C CA  . SER A 1 70  ? 150.409 100.578 97.231  1 64.421  ? 508 SER A CA  1 
ATOM 551  C C   . SER A 1 70  ? 150.694 101.267 98.566  1 61.146  ? 508 SER A C   1 
ATOM 552  O O   . SER A 1 70  ? 150.356 102.433 98.739  1 62.035  ? 508 SER A O   1 
ATOM 553  C CB  . SER A 1 70  ? 149.139 99.779  97.328  1 69.361  ? 508 SER A CB  1 
ATOM 554  O OG  . SER A 1 70  ? 148.896 99.056  96.132  1 72.282  ? 508 SER A OG  1 
ATOM 555  N N   . LEU A 1 71  ? 151.341 100.557 99.498  1 59.043  ? 509 LEU A N   1 
ATOM 556  C CA  . LEU A 1 71  ? 151.559 101.081 100.835 1 57.679  ? 509 LEU A CA  1 
ATOM 557  C C   . LEU A 1 71  ? 152.719 102.07  100.902 1 60.214  ? 509 LEU A C   1 
ATOM 558  O O   . LEU A 1 71  ? 153.042 102.512 101.993 1 65.541  ? 509 LEU A O   1 
ATOM 559  C CB  . LEU A 1 71  ? 151.816 99.921  101.79  1 59.578  ? 509 LEU A CB  1 
ATOM 560  C CG  . LEU A 1 71  ? 150.709 98.873  101.884 1 62.473  ? 509 LEU A CG  1 
ATOM 561  C CD1 . LEU A 1 71  ? 150.989 97.918  103.024 1 62.713  ? 509 LEU A CD1 1 
ATOM 562  C CD2 . LEU A 1 71  ? 149.356 99.537  102.052 1 63.44   ? 509 LEU A CD2 1 
ATOM 563  N N   . GLN A 1 72  ? 153.36  102.418 99.783  1 60.519  ? 510 GLN A N   1 
ATOM 564  C CA  . GLN A 1 72  ? 154.608 103.166 99.845  1 63.543  ? 510 GLN A CA  1 
ATOM 565  C C   . GLN A 1 72  ? 154.436 104.452 100.654 1 56.275  ? 510 GLN A C   1 
ATOM 566  O O   . GLN A 1 72  ? 155.283 104.79  101.476 1 61.555  ? 510 GLN A O   1 
ATOM 567  C CB  . GLN A 1 72  ? 155.096 103.448 98.427  1 69.144  ? 510 GLN A CB  1 
ATOM 568  C CG  . GLN A 1 72  ? 156.318 104.353 98.35   1 80.989  ? 510 GLN A CG  1 
ATOM 569  C CD  . GLN A 1 72  ? 156.717 104.619 96.916  1 87.895  ? 510 GLN A CD  1 
ATOM 570  O OE1 . GLN A 1 72  ? 156.279 103.921 95.992  1 88.075  ? 510 GLN A OE1 1 
ATOM 571  N NE2 . GLN A 1 72  ? 157.533 105.643 96.714  1 93.696  ? 510 GLN A NE2 1 
ATOM 572  N N   . TYR A 1 73  ? 153.351 105.181 100.389 1 54.08   ? 511 TYR A N   1 
ATOM 573  C CA  . TYR A 1 73  ? 153.131 106.488 100.986 1 56.569  ? 511 TYR A CA  1 
ATOM 574  C C   . TYR A 1 73  ? 152.161 106.43  102.17  1 53.741  ? 511 TYR A C   1 
ATOM 575  O O   . TYR A 1 73  ? 151.744 107.467 102.679 1 52.315  ? 511 TYR A O   1 
ATOM 576  C CB  . TYR A 1 73  ? 152.639 107.46  99.913  1 61.172  ? 511 TYR A CB  1 
ATOM 577  C CG  . TYR A 1 73  ? 153.694 107.831 98.88   1 73.797  ? 511 TYR A CG  1 
ATOM 578  C CD1 . TYR A 1 73  ? 154.785 108.627 99.217  1 78.49   ? 511 TYR A CD1 1 
ATOM 579  C CD2 . TYR A 1 73  ? 153.59  107.399 97.562  1 78.327  ? 511 TYR A CD2 1 
ATOM 580  C CE1 . TYR A 1 73  ? 155.747 108.968 98.279  1 82.961  ? 511 TYR A CE1 1 
ATOM 581  C CE2 . TYR A 1 73  ? 154.544 107.738 96.615  1 83.684  ? 511 TYR A CE2 1 
ATOM 582  C CZ  . TYR A 1 73  ? 155.624 108.526 96.973  1 85.123  ? 511 TYR A CZ  1 
ATOM 583  O OH  . TYR A 1 73  ? 156.564 108.859 96.041  1 94.217  ? 511 TYR A OH  1 
ATOM 584  N N   . LEU A 1 74  ? 151.828 105.232 102.653 1 52.212  ? 512 LEU A N   1 
ATOM 585  C CA  . LEU A 1 74  ? 151.155 105.103 103.939 1 53.635  ? 512 LEU A CA  1 
ATOM 586  C C   . LEU A 1 74  ? 152.202 105.106 105.05  1 50.296  ? 512 LEU A C   1 
ATOM 587  O O   . LEU A 1 74  ? 152.945 104.146 105.188 1 55.098  ? 512 LEU A O   1 
ATOM 588  C CB  . LEU A 1 74  ? 150.345 103.811 103.972 1 54.446  ? 512 LEU A CB  1 
ATOM 589  C CG  . LEU A 1 74  ? 149.526 103.574 105.244 1 56.972  ? 512 LEU A CG  1 
ATOM 590  C CD1 . LEU A 1 74  ? 148.414 104.585 105.372 1 58.227  ? 512 LEU A CD1 1 
ATOM 591  C CD2 . LEU A 1 74  ? 148.974 102.174 105.271 1 57.075  ? 512 LEU A CD2 1 
ATOM 592  N N   . PRO A 1 75  ? 152.307 106.16  105.887 1 52.549  ? 513 PRO A N   1 
ATOM 593  C CA  . PRO A 1 75  ? 153.379 106.239 106.87  1 51.802  ? 513 PRO A CA  1 
ATOM 594  C C   . PRO A 1 75  ? 153.159 105.28  108.029 1 53.73   ? 513 PRO A C   1 
ATOM 595  O O   . PRO A 1 75  ? 152.022 105.099 108.456 1 59.441  ? 513 PRO A O   1 
ATOM 596  C CB  . PRO A 1 75  ? 153.347 107.689 107.343 1 54.69   ? 513 PRO A CB  1 
ATOM 597  C CG  . PRO A 1 75  ? 152.225 108.363 106.577 1 59.865  ? 513 PRO A CG  1 
ATOM 598  C CD  . PRO A 1 75  ? 151.37  107.283 105.99  1 53.324  ? 513 PRO A CD  1 
ATOM 599  N N   . TYR A 1 76  ? 154.232 104.678 108.547 1 60.539  ? 514 TYR A N   1 
ATOM 600  C CA  . TYR A 1 76  ? 154.091 103.811 109.706 1 58.273  ? 514 TYR A CA  1 
ATOM 601  C C   . TYR A 1 76  ? 155.219 103.975 110.726 1 61.925  ? 514 TYR A C   1 
ATOM 602  O O   . TYR A 1 76  ? 155.082 103.466 111.834 1 63.669  ? 514 TYR A O   1 
ATOM 603  C CB  . TYR A 1 76  ? 154.022 102.356 109.245 1 61.389  ? 514 TYR A CB  1 
ATOM 604  C CG  . TYR A 1 76  ? 155.344 101.778 108.764 1 64.468  ? 514 TYR A CG  1 
ATOM 605  C CD1 . TYR A 1 76  ? 155.854 102.099 107.514 1 67.834  ? 514 TYR A CD1 1 
ATOM 606  C CD2 . TYR A 1 76  ? 156.075 100.903 109.562 1 69.402  ? 514 TYR A CD2 1 
ATOM 607  C CE1 . TYR A 1 76  ? 157.05  101.559 107.064 1 71.914  ? 514 TYR A CE1 1 
ATOM 608  C CE2 . TYR A 1 76  ? 157.28  100.372 109.131 1 70.318  ? 514 TYR A CE2 1 
ATOM 609  C CZ  . TYR A 1 76  ? 157.769 100.701 107.879 1 71.647  ? 514 TYR A CZ  1 
ATOM 610  O OH  . TYR A 1 76  ? 158.954 100.171 107.454 1 82.511  ? 514 TYR A OH  1 
ATOM 611  N N   . ARG A 1 77  ? 156.316 104.661 110.385 1 64.076  ? 515 ARG A N   1 
ATOM 612  C CA  . ARG A 1 77  ? 157.493 104.676 111.243 1 69.027  ? 515 ARG A CA  1 
ATOM 613  C C   . ARG A 1 77  ? 157.451 105.851 112.218 1 69.148  ? 515 ARG A C   1 
ATOM 614  O O   . ARG A 1 77  ? 156.823 106.872 111.946 1 68.154  ? 515 ARG A O   1 
ATOM 615  C CB  . ARG A 1 77  ? 158.749 104.704 110.368 1 70.362  ? 515 ARG A CB  1 
ATOM 616  C CG  . ARG A 1 77  ? 158.979 103.389 109.637 1 79.768  ? 515 ARG A CG  1 
ATOM 617  C CD  . ARG A 1 77  ? 159.819 103.544 108.383 1 90.894  ? 515 ARG A CD  1 
ATOM 618  N NE  . ARG A 1 77  ? 160.957 104.456 108.547 1 101.957 ? 515 ARG A NE  1 
ATOM 619  C CZ  . ARG A 1 77  ? 161.684 104.943 107.545 1 117.307 ? 515 ARG A CZ  1 
ATOM 620  N NH1 . ARG A 1 77  ? 161.449 104.571 106.295 1 120.819 ? 515 ARG A NH1 1 
ATOM 621  N NH2 . ARG A 1 77  ? 162.661 105.8   107.795 1 119.602 ? 515 ARG A NH2 1 
ATOM 622  N N   . ASP A 1 78  ? 158.159 105.693 113.346 1 75.741  ? 516 ASP A N   1 
ATOM 623  C CA  . ASP A 1 78  ? 158.317 106.739 114.348 1 77.42   ? 516 ASP A CA  1 
ATOM 624  C C   . ASP A 1 78  ? 156.965 107.099 114.956 1 76.835  ? 516 ASP A C   1 
ATOM 625  O O   . ASP A 1 78  ? 156.688 108.264 115.237 1 86.582  ? 516 ASP A O   1 
ATOM 626  C CB  . ASP A 1 78  ? 159.027 107.955 113.773 1 82.859  ? 516 ASP A CB  1 
ATOM 627  C CG  . ASP A 1 78  ? 160.39  107.664 113.167 1 93.606  ? 516 ASP A CG  1 
ATOM 628  O OD1 . ASP A 1 78  ? 160.895 106.541 113.386 1 95.999  ? 516 ASP A OD1 1 
ATOM 629  O OD2 . ASP A 1 78  ? 160.933 108.559 112.482 1 102.254 ? 516 ASP A OD2 1 
ATOM 630  N N   . TYR A 1 79  ? 156.129 106.081 115.157 1 70.746  ? 517 TYR A N   1 
ATOM 631  C CA  . TYR A 1 79  ? 154.818 106.252 115.756 1 65.51   ? 517 TYR A CA  1 
ATOM 632  C C   . TYR A 1 79  ? 154.721 105.309 116.946 1 67.19   ? 517 TYR A C   1 
ATOM 633  O O   . TYR A 1 79  ? 155.247 104.2   116.898 1 72.537  ? 517 TYR A O   1 
ATOM 634  C CB  . TYR A 1 79  ? 153.698 105.941 114.763 1 65.507  ? 517 TYR A CB  1 
ATOM 635  C CG  . TYR A 1 79  ? 152.307 106.133 115.348 1 62.374  ? 517 TYR A CG  1 
ATOM 636  C CD1 . TYR A 1 79  ? 151.731 107.394 115.395 1 60.033  ? 517 TYR A CD1 1 
ATOM 637  C CD2 . TYR A 1 79  ? 151.593 105.067 115.881 1 60.32   ? 517 TYR A CD2 1 
ATOM 638  C CE1 . TYR A 1 79  ? 150.478 107.59  115.943 1 58.803  ? 517 TYR A CE1 1 
ATOM 639  C CE2 . TYR A 1 79  ? 150.337 105.247 116.43  1 61.364  ? 517 TYR A CE2 1 
ATOM 640  C CZ  . TYR A 1 79  ? 149.776 106.513 116.458 1 63.691  ? 517 TYR A CZ  1 
ATOM 641  O OH  . TYR A 1 79  ? 148.54  106.715 117     1 60.53   ? 517 TYR A OH  1 
ATOM 642  N N   . ASN A 1 80  ? 154.071 105.771 118.016 1 69.093  ? 518 ASN A N   1 
ATOM 643  C CA  . ASN A 1 80  ? 154.003 104.993 119.238 1 72.748  ? 518 ASN A CA  1 
ATOM 644  C C   . ASN A 1 80  ? 152.845 104.008 119.134 1 66.593  ? 518 ASN A C   1 
ATOM 645  O O   . ASN A 1 80  ? 151.7   104.371 119.371 1 67.362  ? 518 ASN A O   1 
ATOM 646  C CB  . ASN A 1 80  ? 153.876 105.879 120.471 1 75.293  ? 518 ASN A CB  1 
ATOM 647  C CG  . ASN A 1 80  ? 154.118 105.087 121.731 1 81.594  ? 518 ASN A CG  1 
ATOM 648  O OD1 . ASN A 1 80  ? 153.187 104.864 122.51  1 83.009  ? 518 ASN A OD1 1 
ATOM 649  N ND2 . ASN A 1 80  ? 155.354 104.654 121.944 1 91.657  ? 518 ASN A ND2 1 
ATOM 650  N N   . TYR A 1 81  ? 153.16  102.753 118.809 1 65.905  ? 519 TYR A N   1 
ATOM 651  C CA  . TYR A 1 81  ? 152.146 101.724 118.665 1 62.556  ? 519 TYR A CA  1 
ATOM 652  C C   . TYR A 1 81  ? 151.805 101.077 120.005 1 67.296  ? 519 TYR A C   1 
ATOM 653  O O   . TYR A 1 81  ? 150.803 100.377 120.085 1 64.24   ? 519 TYR A O   1 
ATOM 654  C CB  . TYR A 1 81  ? 152.606 100.622 117.709 1 64.75   ? 519 TYR A CB  1 
ATOM 655  C CG  . TYR A 1 81  ? 152.706 101.125 116.282 1 64.895  ? 519 TYR A CG  1 
ATOM 656  C CD1 . TYR A 1 81  ? 151.561 101.339 115.528 1 68.077  ? 519 TYR A CD1 1 
ATOM 657  C CD2 . TYR A 1 81  ? 153.933 101.435 115.716 1 64.967  ? 519 TYR A CD2 1 
ATOM 658  C CE1 . TYR A 1 81  ? 151.635 101.825 114.234 1 67.742  ? 519 TYR A CE1 1 
ATOM 659  C CE2 . TYR A 1 81  ? 154.022 101.919 114.424 1 64.439  ? 519 TYR A CE2 1 
ATOM 660  C CZ  . TYR A 1 81  ? 152.869 102.113 113.683 1 66.563  ? 519 TYR A CZ  1 
ATOM 661  O OH  . TYR A 1 81  ? 152.904 102.587 112.41  1 63.693  ? 519 TYR A OH  1 
ATOM 662  N N   . SER A 1 82  ? 152.633 101.277 121.036 1 64.382  ? 520 SER A N   1 
ATOM 663  C CA  . SER A 1 82  ? 152.391 100.647 122.326 1 68.487  ? 520 SER A CA  1 
ATOM 664  C C   . SER A 1 82  ? 151.015 101.033 122.867 1 69.34   ? 520 SER A C   1 
ATOM 665  O O   . SER A 1 82  ? 150.357 100.224 123.513 1 73.847  ? 520 SER A O   1 
ATOM 666  C CB  . SER A 1 82  ? 153.473 100.974 123.315 1 68.385  ? 520 SER A CB  1 
ATOM 667  O OG  . SER A 1 82  ? 153.324 102.296 123.81  1 69.987  ? 520 SER A OG  1 
ATOM 668  N N   . LEU A 1 83  ? 150.593 102.275 122.612 1 68.857  ? 521 LEU A N   1 
ATOM 669  C CA  . LEU A 1 83  ? 149.332 102.775 123.134 1 70.05   ? 521 LEU A CA  1 
ATOM 670  C C   . LEU A 1 83  ? 148.147 102.303 122.296 1 72.193  ? 521 LEU A C   1 
ATOM 671  O O   . LEU A 1 83  ? 147.01  102.433 122.734 1 70.065  ? 521 LEU A O   1 
ATOM 672  C CB  . LEU A 1 83  ? 149.359 104.3   123.22  1 71.72   ? 521 LEU A CB  1 
ATOM 673  C CG  . LEU A 1 83  ? 150.111 104.896 124.413 1 72.811  ? 521 LEU A CG  1 
ATOM 674  C CD1 . LEU A 1 83  ? 149.892 106.398 124.481 1 70.918  ? 521 LEU A CD1 1 
ATOM 675  C CD2 . LEU A 1 83  ? 149.709 104.241 125.724 1 72.593  ? 521 LEU A CD2 1 
ATOM 676  N N   . VAL A 1 84  ? 148.397 101.775 121.093 1 72.876  ? 522 VAL A N   1 
ATOM 677  C CA  . VAL A 1 84  ? 147.318 101.388 120.197 1 69.535  ? 522 VAL A CA  1 
ATOM 678  C C   . VAL A 1 84  ? 147.012 99.898  120.336 1 71.105  ? 522 VAL A C   1 
ATOM 679  O O   . VAL A 1 84  ? 145.862 99.487  120.175 1 68.416  ? 522 VAL A O   1 
ATOM 680  C CB  . VAL A 1 84  ? 147.661 101.753 118.739 1 67.817  ? 522 VAL A CB  1 
ATOM 681  C CG1 . VAL A 1 84  ? 146.677 101.142 117.747 1 69.577  ? 522 VAL A CG1 1 
ATOM 682  C CG2 . VAL A 1 84  ? 147.727 103.258 118.552 1 66.234  ? 522 VAL A CG2 1 
ATOM 683  N N   . MET A 1 85  ? 148.046 99.093  120.602 1 77.433  ? 523 MET A N   1 
ATOM 684  C CA  . MET A 1 85  ? 147.878 97.655  120.723 1 81.168  ? 523 MET A CA  1 
ATOM 685  C C   . MET A 1 85  ? 146.909 97.32   121.851 1 79.323  ? 523 MET A C   1 
ATOM 686  O O   . MET A 1 85  ? 146.99  97.871  122.946 1 81.994  ? 523 MET A O   1 
ATOM 687  C CB  . MET A 1 85  ? 149.217 96.972  120.998 1 87.813  ? 523 MET A CB  1 
ATOM 688  C CG  . MET A 1 85  ? 150.089 96.889  119.774 1 94.155  ? 523 MET A CG  1 
ATOM 689  S SD  . MET A 1 85  ? 151.596 95.966  120.123 1 107.76  ? 523 MET A SD  1 
ATOM 690  C CE  . MET A 1 85  ? 152.406 97.193  121.154 1 103.878 ? 523 MET A CE  1 
ATOM 691  N N   . GLY A 1 86  ? 145.982 96.407  121.55  1 77.513  ? 524 GLY A N   1 
ATOM 692  C CA  . GLY A 1 86  ? 145.044 95.897  122.532 1 79.128  ? 524 GLY A CA  1 
ATOM 693  C C   . GLY A 1 86  ? 144.134 96.985  123.098 1 81.769  ? 524 GLY A C   1 
ATOM 694  O O   . GLY A 1 86  ? 143.472 96.756  124.107 1 88.064  ? 524 GLY A O   1 
ATOM 695  N N   . ALA A 1 87  ? 144.106 98.165  122.463 1 77.834  ? 525 ALA A N   1 
ATOM 696  C CA  . ALA A 1 87  ? 143.275 99.254  122.955 1 75.303  ? 525 ALA A CA  1 
ATOM 697  C C   . ALA A 1 87  ? 142.451 99.888  121.836 1 77.652  ? 525 ALA A C   1 
ATOM 698  O O   . ALA A 1 87  ? 141.271 100.165 122.031 1 79.397  ? 525 ALA A O   1 
ATOM 699  C CB  . ALA A 1 87  ? 144.123 100.295 123.648 1 75.153  ? 525 ALA A CB  1 
ATOM 700  N N   . CYS A 1 88  ? 143.075 100.157 120.683 1 74.975  ? 526 CYS A N   1 
ATOM 701  C CA  . CYS A 1 88  ? 142.52  101.121 119.742 1 71.762  ? 526 CYS A CA  1 
ATOM 702  C C   . CYS A 1 88  ? 142.355 100.57  118.329 1 69.721  ? 526 CYS A C   1 
ATOM 703  O O   . CYS A 1 88  ? 141.448 100.998 117.621 1 69.223  ? 526 CYS A O   1 
ATOM 704  C CB  . CYS A 1 88  ? 143.371 102.379 119.693 1 74.756  ? 526 CYS A CB  1 
ATOM 705  S SG  . CYS A 1 88  ? 142.975 103.516 121.044 1 78.461  ? 526 CYS A SG  1 
ATOM 706  N N   . CYS A 1 89  ? 143.241 99.669  117.899 1 68.018  ? 527 CYS A N   1 
ATOM 707  C CA  . CYS A 1 89  ? 143.138 99.142  116.549 1 62.103  ? 527 CYS A CA  1 
ATOM 708  C C   . CYS A 1 89  ? 143.816 97.778  116.486 1 60.904  ? 527 CYS A C   1 
ATOM 709  O O   . CYS A 1 89  ? 144.668 97.462  117.318 1 71.451  ? 527 CYS A O   1 
ATOM 710  C CB  . CYS A 1 89  ? 143.747 100.136 115.563 1 63.599  ? 527 CYS A CB  1 
ATOM 711  S SG  . CYS A 1 89  ? 143.16  99.95   113.855 1 62.17   ? 527 CYS A SG  1 
ATOM 712  N N   . GLU A 1 90  ? 143.42  96.99   115.483 1 58.609  ? 528 GLU A N   1 
ATOM 713  C CA  . GLU A 1 90  ? 143.991 95.672  115.251 1 59.972  ? 528 GLU A CA  1 
ATOM 714  C C   . GLU A 1 90  ? 144.454 95.569  113.803 1 55.655  ? 528 GLU A C   1 
ATOM 715  O O   . GLU A 1 90  ? 144.002 96.341  112.959 1 55.811  ? 528 GLU A O   1 
ATOM 716  C CB  . GLU A 1 90  ? 142.987 94.554  115.53  1 65.058  ? 528 GLU A CB  1 
ATOM 717  C CG  . GLU A 1 90  ? 142.372 94.608  116.926 1 69.215  ? 528 GLU A CG  1 
ATOM 718  C CD  . GLU A 1 90  ? 141.224 95.595  117.075 1 71.957  ? 528 GLU A CD  1 
ATOM 719  O OE1 . GLU A 1 90  ? 140.304 95.586  116.228 1 69.252  ? 528 GLU A OE1 1 
ATOM 720  O OE2 . GLU A 1 90  ? 141.233 96.375  118.054 1 74.084  ? 528 GLU A OE2 1 
ATOM 721  N N   . ASN A 1 91  ? 145.366 94.62   113.551 1 57.441  ? 529 ASN A N   1 
ATOM 722  C CA  . ASN A 1 91  ? 145.984 94.429  112.253 1 54.22   ? 529 ASN A CA  1 
ATOM 723  C C   . ASN A 1 91  ? 146.502 95.751  111.707 1 51.039  ? 529 ASN A C   1 
ATOM 724  O O   . ASN A 1 91  ? 146.221 96.102  110.564 1 48.946  ? 529 ASN A O   1 
ATOM 725  C CB  . ASN A 1 91  ? 145.006 93.834  111.252 1 61.472  ? 529 ASN A CB  1 
ATOM 726  C CG  . ASN A 1 91  ? 144.361 92.569  111.761 1 69.837  ? 529 ASN A CG  1 
ATOM 727  O OD1 . ASN A 1 91  ? 143.138 92.436  111.681 1 68.523  ? 529 ASN A OD1 1 
ATOM 728  N ND2 . ASN A 1 91  ? 145.156 91.627  112.251 1 80.035  ? 529 ASN A ND2 1 
ATOM 729  N N   . VAL A 1 92  ? 147.281 96.459  112.52  1 51.373  ? 530 VAL A N   1 
ATOM 730  C CA  . VAL A 1 92  ? 147.732 97.791  112.17  1 53.395  ? 530 VAL A CA  1 
ATOM 731  C C   . VAL A 1 92  ? 148.81  97.709  111.095 1 51.664  ? 530 VAL A C   1 
ATOM 732  O O   . VAL A 1 92  ? 149.749 96.912  111.191 1 55.912  ? 530 VAL A O   1 
ATOM 733  C CB  . VAL A 1 92  ? 148.245 98.509  113.428 1 55.432  ? 530 VAL A CB  1 
ATOM 734  C CG1 . VAL A 1 92  ? 148.897 99.842  113.106 1 53.819  ? 530 VAL A CG1 1 
ATOM 735  C CG2 . VAL A 1 92  ? 147.105 98.697  114.408 1 58.715  ? 530 VAL A CG2 1 
ATOM 736  N N   . ILE A 1 93  ? 148.681 98.591  110.101 1 48.582  ? 531 ILE A N   1 
ATOM 737  C CA  . ILE A 1 93  ? 149.626 98.643  108.999 1 50.417  ? 531 ILE A CA  1 
ATOM 738  C C   . ILE A 1 93  ? 150.128 100.066 108.811 1 45.293  ? 531 ILE A C   1 
ATOM 739  O O   . ILE A 1 93  ? 150.763 100.359 107.809 1 48.025  ? 531 ILE A O   1 
ATOM 740  C CB  . ILE A 1 93  ? 148.982 98.118  107.708 1 51.587  ? 531 ILE A CB  1 
ATOM 741  C CG1 . ILE A 1 93  ? 147.811 99      107.297 1 59.833  ? 531 ILE A CG1 1 
ATOM 742  C CG2 . ILE A 1 93  ? 148.566 96.658  107.86  1 53.934  ? 531 ILE A CG2 1 
ATOM 743  C CD1 . ILE A 1 93  ? 147.676 99.166  105.802 1 66.813  ? 531 ILE A CD1 1 
ATOM 744  N N   . GLY A 1 94  ? 149.838 100.943 109.773 1 46.094  ? 532 GLY A N   1 
ATOM 745  C CA  . GLY A 1 94  ? 150.346 102.299 109.738 1 44.78   ? 532 GLY A CA  1 
ATOM 746  C C   . GLY A 1 94  ? 149.295 103.249 110.289 1 44.255  ? 532 GLY A C   1 
ATOM 747  O O   . GLY A 1 94  ? 148.412 102.84  111.038 1 46.724  ? 532 GLY A O   1 
ATOM 748  N N   . TYR A 1 95  ? 149.393 104.515 109.901 1 42.594  ? 533 TYR A N   1 
ATOM 749  C CA  . TYR A 1 95  ? 148.467 105.513 110.386 1 45.112  ? 533 TYR A CA  1 
ATOM 750  C C   . TYR A 1 95  ? 148.125 106.471 109.255 1 47.103  ? 533 TYR A C   1 
ATOM 751  O O   . TYR A 1 95  ? 148.917 106.679 108.35  1 45.197  ? 533 TYR A O   1 
ATOM 752  C CB  . TYR A 1 95  ? 149.045 106.286 111.575 1 45.291  ? 533 TYR A CB  1 
ATOM 753  C CG  . TYR A 1 95  ? 150.398 106.921 111.317 1 46.704  ? 533 TYR A CG  1 
ATOM 754  C CD1 . TYR A 1 95  ? 151.575 106.208 111.51  1 47.805  ? 533 TYR A CD1 1 
ATOM 755  C CD2 . TYR A 1 95  ? 150.491 108.227 110.86  1 47.567  ? 533 TYR A CD2 1 
ATOM 756  C CE1 . TYR A 1 95  ? 152.812 106.789 111.29  1 49.037  ? 533 TYR A CE1 1 
ATOM 757  C CE2 . TYR A 1 95  ? 151.728 108.827 110.658 1 49.099  ? 533 TYR A CE2 1 
ATOM 758  C CZ  . TYR A 1 95  ? 152.886 108.098 110.854 1 46.777  ? 533 TYR A CZ  1 
ATOM 759  O OH  . TYR A 1 95  ? 154.089 108.703 110.619 1 61.012  ? 533 TYR A OH  1 
ATOM 760  N N   . MET A 1 96  ? 146.96  107.1   109.372 1 44.069  ? 534 MET A N   1 
ATOM 761  C CA  . MET A 1 96  ? 146.473 108.021 108.364 1 44.206  ? 534 MET A CA  1 
ATOM 762  C C   . MET A 1 96  ? 146.586 109.435 108.9   1 44.234  ? 534 MET A C   1 
ATOM 763  O O   . MET A 1 96  ? 145.888 109.784 109.848 1 47.522  ? 534 MET A O   1 
ATOM 764  C CB  . MET A 1 96  ? 145.008 107.724 108.035 1 45.684  ? 534 MET A CB  1 
ATOM 765  C CG  . MET A 1 96  ? 144.398 108.61  106.958 1 48.275  ? 534 MET A CG  1 
ATOM 766  S SD  . MET A 1 96  ? 145.298 108.542 105.396 1 46.843  ? 534 MET A SD  1 
ATOM 767  C CE  . MET A 1 96  ? 145.444 106.774 105.162 1 45.41   ? 534 MET A CE  1 
ATOM 768  N N   . PRO A 1 97  ? 147.483 110.286 108.347 1 46.711  ? 535 PRO A N   1 
ATOM 769  C CA  . PRO A 1 97  ? 147.599 111.653 108.826 1 46.08   ? 535 PRO A CA  1 
ATOM 770  C C   . PRO A 1 97  ? 146.41  112.507 108.389 1 47.066  ? 535 PRO A C   1 
ATOM 771  O O   . PRO A 1 97  ? 146.089 112.56  107.206 1 49.589  ? 535 PRO A O   1 
ATOM 772  C CB  . PRO A 1 97  ? 148.913 112.153 108.224 1 46.284  ? 535 PRO A CB  1 
ATOM 773  C CG  . PRO A 1 97  ? 149.541 110.958 107.543 1 45.791  ? 535 PRO A CG  1 
ATOM 774  C CD  . PRO A 1 97  ? 148.448 109.971 107.285 1 43.562  ? 535 PRO A CD  1 
ATOM 775  N N   . ILE A 1 98  ? 145.764 113.177 109.345 1 46.607  ? 536 ILE A N   1 
ATOM 776  C CA  . ILE A 1 98  ? 144.705 114.122 109.031 1 44.704  ? 536 ILE A CA  1 
ATOM 777  C C   . ILE A 1 98  ? 145.177 115.522 109.388 1 42.83   ? 536 ILE A C   1 
ATOM 778  O O   . ILE A 1 98  ? 145.483 115.772 110.549 1 46.86   ? 536 ILE A O   1 
ATOM 779  C CB  . ILE A 1 98  ? 143.41  113.793 109.793 1 46.11   ? 536 ILE A CB  1 
ATOM 780  C CG1 . ILE A 1 98  ? 143.053 112.325 109.728 1 48.946  ? 536 ILE A CG1 1 
ATOM 781  C CG2 . ILE A 1 98  ? 142.271 114.669 109.282 1 44.921  ? 536 ILE A CG2 1 
ATOM 782  C CD1 . ILE A 1 98  ? 142.815 111.816 108.322 1 49.427  ? 536 ILE A CD1 1 
ATOM 783  N N   . PRO A 1 99  ? 145.278 116.469 108.425 1 46.112  ? 537 PRO A N   1 
ATOM 784  C CA  . PRO A 1 99  ? 145.784 117.796 108.732 1 45.738  ? 537 PRO A CA  1 
ATOM 785  C C   . PRO A 1 99  ? 144.971 118.444 109.838 1 46.538  ? 537 PRO A C   1 
ATOM 786  O O   . PRO A 1 99  ? 143.758 118.287 109.863 1 45.948  ? 537 PRO A O   1 
ATOM 787  C CB  . PRO A 1 99  ? 145.648 118.567 107.421 1 47.808  ? 537 PRO A CB  1 
ATOM 788  C CG  . PRO A 1 99  ? 145.626 117.483 106.363 1 49.031  ? 537 PRO A CG  1 
ATOM 789  C CD  . PRO A 1 99  ? 144.944 116.312 107.004 1 48.762  ? 537 PRO A CD  1 
ATOM 790  N N   . VAL A 1 100 ? 145.638 119.172 110.73  1 47.023  ? 538 VAL A N   1 
ATOM 791  C CA  . VAL A 1 100 ? 144.961 119.826 111.833 1 45.378  ? 538 VAL A CA  1 
ATOM 792  C C   . VAL A 1 100 ? 145.161 121.327 111.725 1 45.7    ? 538 VAL A C   1 
ATOM 793  O O   . VAL A 1 100 ? 146.288 121.812 111.772 1 48.912  ? 538 VAL A O   1 
ATOM 794  C CB  . VAL A 1 100 ? 145.469 119.315 113.193 1 49.03   ? 538 VAL A CB  1 
ATOM 795  C CG1 . VAL A 1 100 ? 144.835 120.08  114.343 1 49.477  ? 538 VAL A CG1 1 
ATOM 796  C CG2 . VAL A 1 100 ? 145.238 117.828 113.345 1 46.505  ? 538 VAL A CG2 1 
ATOM 797  N N   . GLY A 1 101 ? 144.041 122.04  111.589 1 42.821  ? 539 GLY A N   1 
ATOM 798  C CA  . GLY A 1 101 ? 144.027 123.489 111.592 1 46.563  ? 539 GLY A CA  1 
ATOM 799  C C   . GLY A 1 101 ? 143.465 123.983 112.915 1 47.39   ? 539 GLY A C   1 
ATOM 800  O O   . GLY A 1 101 ? 143.024 123.186 113.731 1 51.747  ? 539 GLY A O   1 
ATOM 801  N N   . VAL A 1 102 ? 143.534 125.288 113.143 1 48.174  ? 540 VAL A N   1 
ATOM 802  C CA  . VAL A 1 102 ? 143.103 125.854 114.404 1 51.897  ? 540 VAL A CA  1 
ATOM 803  C C   . VAL A 1 102 ? 142.153 127.008 114.105 1 48.635  ? 540 VAL A C   1 
ATOM 804  O O   . VAL A 1 102 ? 142.488 127.914 113.35  1 52.624  ? 540 VAL A O   1 
ATOM 805  C CB  . VAL A 1 102 ? 144.279 126.307 115.29  1 55.433  ? 540 VAL A CB  1 
ATOM 806  C CG1 . VAL A 1 102 ? 145.296 127.153 114.533 1 62.643  ? 540 VAL A CG1 1 
ATOM 807  C CG2 . VAL A 1 102 ? 143.776 127.067 116.508 1 59.513  ? 540 VAL A CG2 1 
ATOM 808  N N   . ALA A 1 103 ? 140.956 126.943 114.689 1 47.662  ? 541 ALA A N   1 
ATOM 809  C CA  . ALA A 1 103 ? 139.999 128.035 114.602 1 51.908  ? 541 ALA A CA  1 
ATOM 810  C C   . ALA A 1 103 ? 139.909 128.74  115.947 1 48.157  ? 541 ALA A C   1 
ATOM 811  O O   . ALA A 1 103 ? 139.812 128.093 116.982 1 53.217  ? 541 ALA A O   1 
ATOM 812  C CB  . ALA A 1 103 ? 138.65  127.515 114.175 1 51.401  ? 541 ALA A CB  1 
ATOM 813  N N   . GLY A 1 104 ? 139.977 130.068 115.929 1 54.674  ? 542 GLY A N   1 
ATOM 814  C CA  . GLY A 1 104 ? 139.884 130.821 117.162 1 53.252  ? 542 GLY A CA  1 
ATOM 815  C C   . GLY A 1 104 ? 140.637 132.139 117.087 1 53.59   ? 542 GLY A C   1 
ATOM 816  O O   . GLY A 1 104 ? 141.17  132.501 116.041 1 60.427  ? 542 GLY A O   1 
ATOM 817  N N   . PRO A 1 105 ? 140.698 132.903 118.198 1 54.736  ? 543 PRO A N   1 
ATOM 818  C CA  . PRO A 1 105 ? 140.118 132.491 119.474 1 56.284  ? 543 PRO A CA  1 
ATOM 819  C C   . PRO A 1 105 ? 138.589 132.476 119.493 1 54.943  ? 543 PRO A C   1 
ATOM 820  O O   . PRO A 1 105 ? 137.953 133.4   119.002 1 56.415  ? 543 PRO A O   1 
ATOM 821  C CB  . PRO A 1 105 ? 140.64  133.549 120.441 1 56.767  ? 543 PRO A CB  1 
ATOM 822  C CG  . PRO A 1 105 ? 140.809 134.76  119.552 1 55.759  ? 543 PRO A CG  1 
ATOM 823  C CD  . PRO A 1 105 ? 141.345 134.217 118.274 1 55.574  ? 543 PRO A CD  1 
ATOM 824  N N   . LEU A 1 106 ? 138.001 131.423 120.068 1 50.788  ? 544 LEU A N   1 
ATOM 825  C CA  . LEU A 1 106 ? 136.568 131.376 120.299 1 51.498  ? 544 LEU A CA  1 
ATOM 826  C C   . LEU A 1 106 ? 136.285 131.924 121.695 1 49.62   ? 544 LEU A C   1 
ATOM 827  O O   . LEU A 1 106 ? 136.768 131.379 122.68  1 53.033  ? 544 LEU A O   1 
ATOM 828  C CB  . LEU A 1 106 ? 136.046 129.949 120.149 1 49.191  ? 544 LEU A CB  1 
ATOM 829  C CG  . LEU A 1 106 ? 134.538 129.769 120.364 1 54.987  ? 544 LEU A CG  1 
ATOM 830  C CD1 . LEU A 1 106 ? 133.738 130.563 119.345 1 60.328  ? 544 LEU A CD1 1 
ATOM 831  C CD2 . LEU A 1 106 ? 134.121 128.321 120.338 1 58.268  ? 544 LEU A CD2 1 
ATOM 832  N N   . CYS A 1 107 ? 135.552 133.037 121.761 1 52.652  ? 545 CYS A N   1 
ATOM 833  C CA  . CYS A 1 107 ? 135.274 133.704 123.02  1 53.781  ? 545 CYS A CA  1 
ATOM 834  C C   . CYS A 1 107 ? 133.998 133.11  123.593 1 56.06   ? 545 CYS A C   1 
ATOM 835  O O   . CYS A 1 107 ? 132.918 133.439 123.133 1 56.835  ? 545 CYS A O   1 
ATOM 836  C CB  . CYS A 1 107 ? 135.132 135.207 122.834 1 59.565  ? 545 CYS A CB  1 
ATOM 837  S SG  . CYS A 1 107 ? 136.564 135.954 122.015 1 73.067  ? 545 CYS A SG  1 
ATOM 838  N N   . LEU A 1 108 ? 134.136 132.211 124.569 1 52.65   ? 546 LEU A N   1 
ATOM 839  C CA  . LEU A 1 108 ? 133.017 131.438 125.066 1 54.781  ? 546 LEU A CA  1 
ATOM 840  C C   . LEU A 1 108 ? 133.02  131.482 126.591 1 55.959  ? 546 LEU A C   1 
ATOM 841  O O   . LEU A 1 108 ? 134.022 131.171 127.228 1 58.75   ? 546 LEU A O   1 
ATOM 842  C CB  . LEU A 1 108 ? 133.114 130.009 124.539 1 55.579  ? 546 LEU A CB  1 
ATOM 843  C CG  . LEU A 1 108 ? 132.107 129.01  125.111 1 58.684  ? 546 LEU A CG  1 
ATOM 844  C CD1 . LEU A 1 108 ? 130.716 129.34  124.628 1 60.597  ? 546 LEU A CD1 1 
ATOM 845  C CD2 . LEU A 1 108 ? 132.452 127.585 124.745 1 58.459  ? 546 LEU A CD2 1 
ATOM 846  N N   . ASP A 1 109 ? 131.885 131.904 127.158 1 56.601  ? 547 ASP A N   1 
ATOM 847  C CA  . ASP A 1 109 ? 131.688 131.966 128.598 1 57.169  ? 547 ASP A CA  1 
ATOM 848  C C   . ASP A 1 109 ? 132.856 132.675 129.28  1 54.591  ? 547 ASP A C   1 
ATOM 849  O O   . ASP A 1 109 ? 133.357 132.192 130.293 1 60.172  ? 547 ASP A O   1 
ATOM 850  C CB  . ASP A 1 109 ? 131.452 130.573 129.157 1 58.517  ? 547 ASP A CB  1 
ATOM 851  C CG  . ASP A 1 109 ? 130.265 129.853 128.534 1 65.694  ? 547 ASP A CG  1 
ATOM 852  O OD1 . ASP A 1 109 ? 129.145 130.386 128.656 1 66.892  ? 547 ASP A OD1 1 
ATOM 853  O OD2 . ASP A 1 109 ? 130.463 128.781 127.916 1 65.794  ? 547 ASP A OD2 1 
ATOM 854  N N   . GLU A 1 110 ? 133.284 133.804 128.695 1 57.934  ? 548 GLU A N   1 
ATOM 855  C CA  . GLU A 1 110 ? 134.284 134.699 129.263 1 64.514  ? 548 GLU A CA  1 
ATOM 856  C C   . GLU A 1 110 ? 135.699 134.126 129.196 1 62.029  ? 548 GLU A C   1 
ATOM 857  O O   . GLU A 1 110 ? 136.617 134.705 129.776 1 71.211  ? 548 GLU A O   1 
ATOM 858  C CB  . GLU A 1 110 ? 133.959 135.098 130.705 1 69.354  ? 548 GLU A CB  1 
ATOM 859  C CG  . GLU A 1 110 ? 132.621 135.813 130.853 1 76.571  ? 548 GLU A CG  1 
ATOM 860  C CD  . GLU A 1 110 ? 132.503 137.092 130.043 1 90.853  ? 548 GLU A CD  1 
ATOM 861  O OE1 . GLU A 1 110 ? 131.461 137.775 130.163 1 101.512 ? 548 GLU A OE1 1 
ATOM 862  O OE2 . GLU A 1 110 ? 133.452 137.409 129.292 1 97.095  ? 548 GLU A OE2 1 
ATOM 863  N N   . LYS A 1 111 ? 135.884 133.023 128.465 1 63.371  ? 549 LYS A N   1 
ATOM 864  C CA  . LYS A 1 111 ? 137.205 132.463 128.233 1 66.472  ? 549 LYS A CA  1 
ATOM 865  C C   . LYS A 1 111 ? 137.493 132.461 126.737 1 64.549  ? 549 LYS A C   1 
ATOM 866  O O   . LYS A 1 111 ? 136.613 132.747 125.932 1 67.722  ? 549 LYS A O   1 
ATOM 867  C CB  . LYS A 1 111 ? 137.288 131.057 128.828 1 69.725  ? 549 LYS A CB  1 
ATOM 868  C CG  . LYS A 1 111 ? 137.399 131.054 130.343 1 78.392  ? 549 LYS A CG  1 
ATOM 869  C CD  . LYS A 1 111 ? 137.613 129.672 130.944 1 85.303  ? 549 LYS A CD  1 
ATOM 870  C CE  . LYS A 1 111 ? 136.386 129.073 131.557 1 90.172  ? 549 LYS A CE  1 
ATOM 871  N NZ  . LYS A 1 111 ? 135.24  129.043 130.645 1 92.481  ? 549 LYS A NZ  1 
ATOM 872  N N   . GLU A 1 112 ? 138.744 132.167 126.38  1 65.147  ? 550 GLU A N   1 
ATOM 873  C CA  . GLU A 1 112 ? 139.141 132.078 124.986 1 64.128  ? 550 GLU A CA  1 
ATOM 874  C C   . GLU A 1 112 ? 139.667 130.672 124.742 1 57.725  ? 550 GLU A C   1 
ATOM 875  O O   . GLU A 1 112 ? 140.446 130.145 125.533 1 64.924  ? 550 GLU A O   1 
ATOM 876  C CB  . GLU A 1 112 ? 140.194 133.12  124.626 1 68.848  ? 550 GLU A CB  1 
ATOM 877  C CG  . GLU A 1 112 ? 139.817 134.52  125.093 1 77.879  ? 550 GLU A CG  1 
ATOM 878  C CD  . GLU A 1 112 ? 140.014 135.57  124.023 1 87.282  ? 550 GLU A CD  1 
ATOM 879  O OE1 . GLU A 1 112 ? 139.219 135.516 123.064 1 93.36   ? 550 GLU A OE1 1 
ATOM 880  O OE2 . GLU A 1 112 ? 140.933 136.41  124.127 1 96.128  ? 550 GLU A OE2 1 
ATOM 881  N N   . PHE A 1 113 ? 139.23  130.074 123.637 1 52.076  ? 551 PHE A N   1 
ATOM 882  C CA  . PHE A 1 113 ? 139.696 128.757 123.258 1 50.467  ? 551 PHE A CA  1 
ATOM 883  C C   . PHE A 1 113 ? 140.303 128.798 121.868 1 48.36   ? 551 PHE A C   1 
ATOM 884  O O   . PHE A 1 113 ? 139.946 129.638 121.054 1 51.179  ? 551 PHE A O   1 
ATOM 885  C CB  . PHE A 1 113 ? 138.546 127.756 123.281 1 51.114  ? 551 PHE A CB  1 
ATOM 886  C CG  . PHE A 1 113 ? 137.967 127.567 124.668 1 54.671  ? 551 PHE A CG  1 
ATOM 887  C CD1 . PHE A 1 113 ? 138.526 126.661 125.556 1 55.031  ? 551 PHE A CD1 1 
ATOM 888  C CD2 . PHE A 1 113 ? 136.889 128.332 125.086 1 54.71   ? 551 PHE A CD2 1 
ATOM 889  C CE1 . PHE A 1 113 ? 137.997 126.507 126.824 1 57.619  ? 551 PHE A CE1 1 
ATOM 890  C CE2 . PHE A 1 113 ? 136.364 128.172 126.356 1 57.638  ? 551 PHE A CE2 1 
ATOM 891  C CZ  . PHE A 1 113 ? 136.922 127.264 127.223 1 57.041  ? 551 PHE A CZ  1 
ATOM 892  N N   . GLN A 1 114 ? 141.251 127.891 121.637 1 50.366  ? 552 GLN A N   1 
ATOM 893  C CA  . GLN A 1 114 ? 141.836 127.67  120.33  1 49.302  ? 552 GLN A CA  1 
ATOM 894  C C   . GLN A 1 114 ? 141.435 126.256 119.938 1 44.757  ? 552 GLN A C   1 
ATOM 895  O O   . GLN A 1 114 ? 141.926 125.292 120.515 1 49.378  ? 552 GLN A O   1 
ATOM 896  C CB  . GLN A 1 114 ? 143.351 127.873 120.398 1 51.57   ? 552 GLN A CB  1 
ATOM 897  C CG  . GLN A 1 114 ? 143.77  129.267 120.851 1 53.853  ? 552 GLN A CG  1 
ATOM 898  C CD  . GLN A 1 114 ? 143.496 130.343 119.825 1 57.556  ? 552 GLN A CD  1 
ATOM 899  O OE1 . GLN A 1 114 ? 143.238 130.069 118.647 1 63.384  ? 552 GLN A OE1 1 
ATOM 900  N NE2 . GLN A 1 114 ? 143.558 131.59  120.265 1 62.187  ? 552 GLN A NE2 1 
ATOM 901  N N   . VAL A 1 115 ? 140.528 126.139 118.967 1 43.547  ? 553 VAL A N   1 
ATOM 902  C CA  . VAL A 1 115 ? 139.859 124.873 118.715 1 43.948  ? 553 VAL A CA  1 
ATOM 903  C C   . VAL A 1 115 ? 140.563 124.154 117.576 1 42.664  ? 553 VAL A C   1 
ATOM 904  O O   . VAL A 1 115 ? 140.648 124.689 116.477 1 48.785  ? 553 VAL A O   1 
ATOM 905  C CB  . VAL A 1 115 ? 138.374 125.101 118.391 1 44.372  ? 553 VAL A CB  1 
ATOM 906  C CG1 . VAL A 1 115 ? 137.6   123.787 118.322 1 40.861  ? 553 VAL A CG1 1 
ATOM 907  C CG2 . VAL A 1 115 ? 137.747 126.061 119.391 1 45.36   ? 553 VAL A CG2 1 
ATOM 908  N N   . PRO A 1 116 ? 141.153 122.964 117.809 1 44.898  ? 554 PRO A N   1 
ATOM 909  C CA  . PRO A 1 116 ? 141.753 122.204 116.728 1 45.564  ? 554 PRO A CA  1 
ATOM 910  C C   . PRO A 1 116 ? 140.707 121.483 115.891 1 46.741  ? 554 PRO A C   1 
ATOM 911  O O   . PRO A 1 116 ? 139.766 120.906 116.428 1 45.701  ? 554 PRO A O   1 
ATOM 912  C CB  . PRO A 1 116 ? 142.672 121.229 117.442 1 44.435  ? 554 PRO A CB  1 
ATOM 913  C CG  . PRO A 1 116 ? 141.993 121.019 118.766 1 48.457  ? 554 PRO A CG  1 
ATOM 914  C CD  . PRO A 1 116 ? 141.349 122.324 119.117 1 48.19   ? 554 PRO A CD  1 
ATOM 915  N N   . MET A 1 117 ? 140.884 121.523 114.573 1 47.069  ? 555 MET A N   1 
ATOM 916  C CA  . MET A 1 117 ? 139.946 120.901 113.656 1 44.064  ? 555 MET A CA  1 
ATOM 917  C C   . MET A 1 117 ? 140.738 120.081 112.648 1 41.548  ? 555 MET A C   1 
ATOM 918  O O   . MET A 1 117 ? 141.56  120.625 111.92  1 43.659  ? 555 MET A O   1 
ATOM 919  C CB  . MET A 1 117 ? 139.103 121.974 112.959 1 44.589  ? 555 MET A CB  1 
ATOM 920  C CG  . MET A 1 117 ? 138.198 122.736 113.913 1 47.937  ? 555 MET A CG  1 
ATOM 921  S SD  . MET A 1 117 ? 137.308 124.151 113.234 1 51.858  ? 555 MET A SD  1 
ATOM 922  C CE  . MET A 1 117 ? 136.289 123.362 111.986 1 52.397  ? 555 MET A CE  1 
ATOM 923  N N   . ALA A 1 118 ? 140.524 118.765 112.675 1 41.705  ? 556 ALA A N   1 
ATOM 924  C CA  . ALA A 1 118 ? 141.179 117.849 111.769 1 45.23   ? 556 ALA A CA  1 
ATOM 925  C C   . ALA A 1 118 ? 140.276 117.611 110.568 1 46.208  ? 556 ALA A C   1 
ATOM 926  O O   . ALA A 1 118 ? 139.31  116.868 110.66  1 50.859  ? 556 ALA A O   1 
ATOM 927  C CB  . ALA A 1 118 ? 141.514 116.557 112.472 1 44.759  ? 556 ALA A CB  1 
ATOM 928  N N   . THR A 1 119 ? 140.638 118.184 109.422 1 50.441  ? 557 THR A N   1 
ATOM 929  C CA  . THR A 1 119 ? 139.784 118.092 108.253 1 55.974  ? 557 THR A CA  1 
ATOM 930  C C   . THR A 1 119 ? 140.623 118.047 106.984 1 52.589  ? 557 THR A C   1 
ATOM 931  O O   . THR A 1 119 ? 141.726 118.576 106.95  1 53.438  ? 557 THR A O   1 
ATOM 932  C CB  . THR A 1 119 ? 138.836 119.293 108.259 1 59.515  ? 557 THR A CB  1 
ATOM 933  O OG1 . THR A 1 119 ? 138.133 119.251 107.021 1 64.562  ? 557 THR A OG1 1 
ATOM 934  C CG2 . THR A 1 119 ? 139.559 120.618 108.412 1 59.613  ? 557 THR A CG2 1 
ATOM 935  N N   . THR A 1 120 ? 140.038 117.462 105.932 1 53.631  ? 558 THR A N   1 
ATOM 936  C CA  . THR A 1 120 ? 140.58  117.552 104.583 1 57.956  ? 558 THR A CA  1 
ATOM 937  C C   . THR A 1 120 ? 139.654 118.377 103.69  1 58.898  ? 558 THR A C   1 
ATOM 938  O O   . THR A 1 120 ? 139.814 118.388 102.47  1 63.119  ? 558 THR A O   1 
ATOM 939  C CB  . THR A 1 120 ? 140.803 116.159 103.998 1 55.46   ? 558 THR A CB  1 
ATOM 940  O OG1 . THR A 1 120 ? 139.562 115.46  103.978 1 53.523  ? 558 THR A OG1 1 
ATOM 941  C CG2 . THR A 1 120 ? 141.802 115.34  104.794 1 55.916  ? 558 THR A CG2 1 
ATOM 942  N N   . GLU A 1 121 ? 138.699 119.085 104.293 1 57.399  ? 559 GLU A N   1 
ATOM 943  C CA  . GLU A 1 121 ? 137.771 119.904 103.539 1 60.373  ? 559 GLU A CA  1 
ATOM 944  C C   . GLU A 1 121 ? 138.269 121.339 103.509 1 59.313  ? 559 GLU A C   1 
ATOM 945  O O   . GLU A 1 121 ? 138.3   121.997 104.546 1 59.305  ? 559 GLU A O   1 
ATOM 946  C CB  . GLU A 1 121 ? 136.388 119.852 104.177 1 65.223  ? 559 GLU A CB  1 
ATOM 947  C CG  . GLU A 1 121 ? 135.413 120.799 103.494 1 76.308  ? 559 GLU A CG  1 
ATOM 948  C CD  . GLU A 1 121 ? 133.994 120.688 103.997 1 88.106  ? 559 GLU A CD  1 
ATOM 949  O OE1 . GLU A 1 121 ? 133.108 121.169 103.263 1 98.34   ? 559 GLU A OE1 1 
ATOM 950  O OE2 . GLU A 1 121 ? 133.771 120.151 105.105 1 91.254  ? 559 GLU A OE2 1 
ATOM 951  N N   . GLY A 1 122 ? 138.628 121.814 102.311 1 61.048  ? 560 GLY A N   1 
ATOM 952  C CA  . GLY A 1 122 ? 139.169 123.15  102.15  1 59.032  ? 560 GLY A CA  1 
ATOM 953  C C   . GLY A 1 122 ? 138.168 124.22  102.577 1 59.99   ? 560 GLY A C   1 
ATOM 954  O O   . GLY A 1 122 ? 136.981 124.139 102.279 1 64.612  ? 560 GLY A O   1 
ATOM 955  N N   . CYS A 1 123 ? 138.684 125.24  103.263 1 59.178  ? 561 CYS A N   1 
ATOM 956  C CA  . CYS A 1 123 ? 137.941 126.441 103.613 1 59.287  ? 561 CYS A CA  1 
ATOM 957  C C   . CYS A 1 123 ? 137.1   126.259 104.875 1 55.374  ? 561 CYS A C   1 
ATOM 958  O O   . CYS A 1 123 ? 136.576 127.232 105.393 1 48.966  ? 561 CYS A O   1 
ATOM 959  C CB  . CYS A 1 123 ? 137.032 126.935 102.49  1 68.264  ? 561 CYS A CB  1 
ATOM 960  S SG  . CYS A 1 123 ? 137.897 127.237 100.929 1 81.767  ? 561 CYS A SG  1 
ATOM 961  N N   . LEU A 1 124 ? 136.99  125.042 105.41  1 50.124  ? 562 LEU A N   1 
ATOM 962  C CA  . LEU A 1 124 ? 136.179 124.831 106.599 1 49.442  ? 562 LEU A CA  1 
ATOM 963  C C   . LEU A 1 124 ? 136.748 125.595 107.795 1 48.959  ? 562 LEU A C   1 
ATOM 964  O O   . LEU A 1 124 ? 136.015 126.291 108.495 1 45.888  ? 562 LEU A O   1 
ATOM 965  C CB  . LEU A 1 124 ? 136.091 123.339 106.885 1 50.998  ? 562 LEU A CB  1 
ATOM 966  C CG  . LEU A 1 124 ? 135.418 122.956 108.203 1 56.507  ? 562 LEU A CG  1 
ATOM 967  C CD1 . LEU A 1 124 ? 133.989 123.421 108.217 1 59.273  ? 562 LEU A CD1 1 
ATOM 968  C CD2 . LEU A 1 124 ? 135.509 121.471 108.437 1 56.446  ? 562 LEU A CD2 1 
ATOM 969  N N   . VAL A 1 125 ? 138.061 125.504 108.005 1 49.494  ? 563 VAL A N   1 
ATOM 970  C CA  . VAL A 1 125 ? 138.686 126.155 109.14  1 46.386  ? 563 VAL A CA  1 
ATOM 971  C C   . VAL A 1 125 ? 138.581 127.665 108.986 1 46.45   ? 563 VAL A C   1 
ATOM 972  O O   . VAL A 1 125 ? 138.326 128.354 109.97  1 47.979  ? 563 VAL A O   1 
ATOM 973  C CB  . VAL A 1 125 ? 140.146 125.698 109.313 1 49.096  ? 563 VAL A CB  1 
ATOM 974  C CG1 . VAL A 1 125 ? 140.893 126.545 110.327 1 48.694  ? 563 VAL A CG1 1 
ATOM 975  C CG2 . VAL A 1 125 ? 140.21  124.229 109.693 1 49.16   ? 563 VAL A CG2 1 
ATOM 976  N N   . ALA A 1 126 ? 138.803 128.18  107.771 1 46.606  ? 564 ALA A N   1 
ATOM 977  C CA  . ALA A 1 126 ? 138.776 129.617 107.549 1 49.861  ? 564 ALA A CA  1 
ATOM 978  C C   . ALA A 1 126 ? 137.375 130.158 107.838 1 49.364  ? 564 ALA A C   1 
ATOM 979  O O   . ALA A 1 126 ? 137.22  131.224 108.433 1 49.664  ? 564 ALA A O   1 
ATOM 980  C CB  . ALA A 1 126 ? 139.22  129.938 106.138 1 49.663  ? 564 ALA A CB  1 
ATOM 981  N N   . SER A 1 127 ? 136.35  129.425 107.396 1 47.614  ? 565 SER A N   1 
ATOM 982  C CA  . SER A 1 127 ? 134.971 129.847 107.6   1 50.918  ? 565 SER A CA  1 
ATOM 983  C C   . SER A 1 127 ? 134.641 129.858 109.092 1 46.61   ? 565 SER A C   1 
ATOM 984  O O   . SER A 1 127 ? 134.07  130.815 109.606 1 46.78   ? 565 SER A O   1 
ATOM 985  C CB  . SER A 1 127 ? 134.019 128.956 106.849 1 52.051  ? 565 SER A CB  1 
ATOM 986  O OG  . SER A 1 127 ? 132.694 129.468 106.912 1 59.06   ? 565 SER A OG  1 
ATOM 987  N N   . THR A 1 128 ? 135.035 128.794 109.793 1 44.255  ? 566 THR A N   1 
ATOM 988  C CA  . THR A 1 128 ? 134.838 128.738 111.232 1 44.458  ? 566 THR A CA  1 
ATOM 989  C C   . THR A 1 128 ? 135.567 129.896 111.912 1 46.039  ? 566 THR A C   1 
ATOM 990  O O   . THR A 1 128 ? 135.042 130.47  112.863 1 43.997  ? 566 THR A O   1 
ATOM 991  C CB  . THR A 1 128 ? 135.309 127.4   111.786 1 49.332  ? 566 THR A CB  1 
ATOM 992  O OG1 . THR A 1 128 ? 134.737 126.366 110.993 1 49.04   ? 566 THR A OG1 1 
ATOM 993  C CG2 . THR A 1 128 ? 134.899 127.217 113.232 1 50.355  ? 566 THR A CG2 1 
ATOM 994  N N   . ASN A 1 129 ? 136.768 130.236 111.426 1 46.33   ? 567 ASN A N   1 
ATOM 995  C CA  . ASN A 1 129 ? 137.538 131.336 111.978 1 46.954  ? 567 ASN A CA  1 
ATOM 996  C C   . ASN A 1 129 ? 136.774 132.645 111.835 1 46.393  ? 567 ASN A C   1 
ATOM 997  O O   . ASN A 1 129 ? 136.779 133.47  112.746 1 48.947  ? 567 ASN A O   1 
ATOM 998  C CB  . ASN A 1 129 ? 138.906 131.469 111.315 1 53.951  ? 567 ASN A CB  1 
ATOM 999  C CG  . ASN A 1 129 ? 140.014 131.086 112.25  1 58.711  ? 567 ASN A CG  1 
ATOM 1000 O OD1 . ASN A 1 129 ? 140.131 131.681 113.322 1 60.451  ? 567 ASN A OD1 1 
ATOM 1001 N ND2 . ASN A 1 129 ? 140.817 130.102 111.878 1 69.021  ? 567 ASN A ND2 1 
ATOM 1002 N N   . ARG A 1 130 ? 136.172 132.87  110.667 1 45.045  ? 568 ARG A N   1 
ATOM 1003 C CA  . ARG A 1 130 ? 135.451 134.11  110.448 1 47.55   ? 568 ARG A CA  1 
ATOM 1004 C C   . ARG A 1 130 ? 134.268 134.181 111.409 1 48.744  ? 568 ARG A C   1 
ATOM 1005 O O   . ARG A 1 130 ? 133.971 135.223 111.984 1 48.868  ? 568 ARG A O   1 
ATOM 1006 C CB  . ARG A 1 130 ? 134.999 134.208 108.992 1 48.559  ? 568 ARG A CB  1 
ATOM 1007 C CG  . ARG A 1 130 ? 134.29  135.519 108.692 1 52.872  ? 568 ARG A CG  1 
ATOM 1008 C CD  . ARG A 1 130 ? 134.011 135.653 107.218 1 56.303  ? 568 ARG A CD  1 
ATOM 1009 N NE  . ARG A 1 130 ? 132.851 134.857 106.805 1 57.055  ? 568 ARG A NE  1 
ATOM 1010 C CZ  . ARG A 1 130 ? 131.949 135.25  105.913 1 58.73   ? 568 ARG A CZ  1 
ATOM 1011 N NH1 . ARG A 1 130 ? 132.095 136.4   105.274 1 60.891  ? 568 ARG A NH1 1 
ATOM 1012 N NH2 . ARG A 1 130 ? 130.928 134.463 105.618 1 56.481  ? 568 ARG A NH2 1 
ATOM 1013 N N   . GLY A 1 131 ? 133.579 133.058 111.586 1 45.035  ? 569 GLY A N   1 
ATOM 1014 C CA  . GLY A 1 131 ? 132.502 133.01  112.554 1 45.254  ? 569 GLY A CA  1 
ATOM 1015 C C   . GLY A 1 131 ? 132.979 133.326 113.971 1 46.793  ? 569 GLY A C   1 
ATOM 1016 O O   . GLY A 1 131 ? 132.335 134.083 114.691 1 41.737  ? 569 GLY A O   1 
ATOM 1017 N N   . CYS A 1 132 ? 134.114 132.747 114.371 1 43.601  ? 570 CYS A N   1 
ATOM 1018 C CA  . CYS A 1 132 ? 134.701 133.032 115.671 1 45.795  ? 570 CYS A CA  1 
ATOM 1019 C C   . CYS A 1 132 ? 134.995 134.517 115.822 1 44.703  ? 570 CYS A C   1 
ATOM 1020 O O   . CYS A 1 132 ? 134.749 135.087 116.878 1 47.721  ? 570 CYS A O   1 
ATOM 1021 C CB  . CYS A 1 132 ? 135.982 132.239 115.89  1 46.574  ? 570 CYS A CB  1 
ATOM 1022 S SG  . CYS A 1 132 ? 135.695 130.475 116.161 1 52.026  ? 570 CYS A SG  1 
ATOM 1023 N N   . ARG A 1 133 ? 135.526 135.143 114.77  1 46.467  ? 571 ARG A N   1 
ATOM 1024 C CA  . ARG A 1 133 ? 135.868 136.552 114.828 1 49.907  ? 571 ARG A CA  1 
ATOM 1025 C C   . ARG A 1 133 ? 134.606 137.381 115.042 1 51.473  ? 571 ARG A C   1 
ATOM 1026 O O   . ARG A 1 133 ? 134.598 138.33  115.818 1 52.494  ? 571 ARG A O   1 
ATOM 1027 C CB  . ARG A 1 133 ? 136.584 136.966 113.542 1 56.164  ? 571 ARG A CB  1 
ATOM 1028 C CG  . ARG A 1 133 ? 137.001 138.427 113.533 1 65.054  ? 571 ARG A CG  1 
ATOM 1029 C CD  . ARG A 1 133 ? 138.214 138.607 112.628 1 75.214  ? 571 ARG A CD  1 
ATOM 1030 N NE  . ARG A 1 133 ? 137.862 138.881 111.231 1 80.116  ? 571 ARG A NE  1 
ATOM 1031 C CZ  . ARG A 1 133 ? 137.558 140.087 110.762 1 86.881  ? 571 ARG A CZ  1 
ATOM 1032 N NH1 . ARG A 1 133 ? 137.516 141.131 111.576 1 85.782  ? 571 ARG A NH1 1 
ATOM 1033 N NH2 . ARG A 1 133 ? 137.301 140.247 109.475 1 88.672  ? 571 ARG A NH2 1 
ATOM 1034 N N   . ALA A 1 134 ? 133.546 137.051 114.302 1 50.823  ? 572 ALA A N   1 
ATOM 1035 C CA  . ALA A 1 134 ? 132.297 137.786 114.41  1 48.963  ? 572 ALA A CA  1 
ATOM 1036 C C   . ALA A 1 134 ? 131.748 137.68  115.832 1 48.903  ? 572 ALA A C   1 
ATOM 1037 O O   . ALA A 1 134 ? 131.377 138.674 116.439 1 49.799  ? 572 ALA A O   1 
ATOM 1038 C CB  . ALA A 1 134 ? 131.299 137.267 113.403 1 49.59   ? 572 ALA A CB  1 
ATOM 1039 N N   . ILE A 1 135 ? 131.739 136.464 116.376 1 48.453  ? 573 ILE A N   1 
ATOM 1040 C CA  . ILE A 1 135 ? 131.267 136.245 117.733 1 50.526  ? 573 ILE A CA  1 
ATOM 1041 C C   . ILE A 1 135 ? 132.116 137.035 118.73  1 52.29   ? 573 ILE A C   1 
ATOM 1042 O O   . ILE A 1 135 ? 131.572 137.648 119.641 1 52.377  ? 573 ILE A O   1 
ATOM 1043 C CB  . ILE A 1 135 ? 131.253 134.746 118.064 1 48.764  ? 573 ILE A CB  1 
ATOM 1044 C CG1 . ILE A 1 135 ? 130.134 134.009 117.346 1 48.26   ? 573 ILE A CG1 1 
ATOM 1045 C CG2 . ILE A 1 135 ? 131.167 134.522 119.565 1 51.633  ? 573 ILE A CG2 1 
ATOM 1046 C CD1 . ILE A 1 135 ? 130.265 132.506 117.434 1 45.515  ? 573 ILE A CD1 1 
ATOM 1047 N N   . GLY A 1 136 ? 133.438 137.022 118.551 1 52.777  ? 574 GLY A N   1 
ATOM 1048 C CA  . GLY A 1 136 ? 134.336 137.734 119.446 1 53.247  ? 574 GLY A CA  1 
ATOM 1049 C C   . GLY A 1 136 ? 134.05  139.231 119.452 1 53.671  ? 574 GLY A C   1 
ATOM 1050 O O   . GLY A 1 136 ? 134.039 139.85  120.51  1 60.804  ? 574 GLY A O   1 
ATOM 1051 N N   . LEU A 1 137 ? 133.843 139.811 118.265 1 56.728  ? 575 LEU A N   1 
ATOM 1052 C CA  . LEU A 1 137 ? 133.553 141.229 118.153 1 60.675  ? 575 LEU A CA  1 
ATOM 1053 C C   . LEU A 1 137 ? 132.173 141.513 118.734 1 62.674  ? 575 LEU A C   1 
ATOM 1054 O O   . LEU A 1 137 ? 131.871 142.637 119.124 1 64.214  ? 575 LEU A O   1 
ATOM 1055 C CB  . LEU A 1 137 ? 133.65  141.671 116.695 1 64.537  ? 575 LEU A CB  1 
ATOM 1056 C CG  . LEU A 1 137 ? 135.063 141.927 116.168 1 63.6    ? 575 LEU A CG  1 
ATOM 1057 C CD1 . LEU A 1 137 ? 135.028 142.166 114.669 1 63.119  ? 575 LEU A CD1 1 
ATOM 1058 C CD2 . LEU A 1 137 ? 135.7   143.109 116.875 1 63.968  ? 575 LEU A CD2 1 
ATOM 1059 N N   . GLY A 1 138 ? 131.339 140.474 118.797 1 64.001  ? 576 GLY A N   1 
ATOM 1060 C CA  . GLY A 1 138 ? 129.989 140.614 119.306 1 63.537  ? 576 GLY A CA  1 
ATOM 1061 C C   . GLY A 1 138 ? 129.889 140.562 120.831 1 65.514  ? 576 GLY A C   1 
ATOM 1062 O O   . GLY A 1 138 ? 128.789 140.66  121.366 1 68.954  ? 576 GLY A O   1 
ATOM 1063 N N   . GLY A 1 139 ? 131.014 140.39  121.535 1 63.931  ? 577 GLY A N   1 
ATOM 1064 C CA  . GLY A 1 139 ? 131     140.334 122.989 1 61.989  ? 577 GLY A CA  1 
ATOM 1065 C C   . GLY A 1 139 ? 130.947 138.902 123.527 1 61.66   ? 577 GLY A C   1 
ATOM 1066 O O   . GLY A 1 139 ? 130.62  138.681 124.689 1 63.565  ? 577 GLY A O   1 
ATOM 1067 N N   . GLY A 1 140 ? 131.278 137.926 122.68  1 56.235  ? 578 GLY A N   1 
ATOM 1068 C CA  . GLY A 1 140 ? 131.471 136.563 123.133 1 54.656  ? 578 GLY A CA  1 
ATOM 1069 C C   . GLY A 1 140 ? 130.157 135.793 123.18  1 51.707  ? 578 GLY A C   1 
ATOM 1070 O O   . GLY A 1 140 ? 129.074 136.364 123.127 1 55.664  ? 578 GLY A O   1 
ATOM 1071 N N   . ALA A 1 141 ? 130.283 134.477 123.285 1 46.86   ? 579 ALA A N   1 
ATOM 1072 C CA  . ALA A 1 141 ? 129.138 133.595 123.34  1 48.421  ? 579 ALA A CA  1 
ATOM 1073 C C   . ALA A 1 141 ? 128.951 133.067 124.76  1 47.283  ? 579 ALA A C   1 
ATOM 1074 O O   . ALA A 1 141 ? 129.797 133.23  125.634 1 52.708  ? 579 ALA A O   1 
ATOM 1075 C CB  . ALA A 1 141 ? 129.309 132.466 122.356 1 49.642  ? 579 ALA A CB  1 
ATOM 1076 N N   . SER A 1 142 ? 127.781 132.473 124.978 1 47.382  ? 580 SER A N   1 
ATOM 1077 C CA  . SER A 1 142 ? 127.401 131.915 126.264 1 49.105  ? 580 SER A CA  1 
ATOM 1078 C C   . SER A 1 142 ? 126.803 130.545 126.009 1 45.849  ? 580 SER A C   1 
ATOM 1079 O O   . SER A 1 142 ? 126.127 130.344 125.008 1 49.221  ? 580 SER A O   1 
ATOM 1080 C CB  . SER A 1 142 ? 126.415 132.788 126.999 1 51.615  ? 580 SER A CB  1 
ATOM 1081 O OG  . SER A 1 142 ? 126.979 134.035 127.381 1 56.621  ? 580 SER A OG  1 
ATOM 1082 N N   . SER A 1 143 ? 127.086 129.6   126.9   1 44.341  ? 581 SER A N   1 
ATOM 1083 C CA  . SER A 1 143 ? 126.599 128.249 126.731 1 45.908  ? 581 SER A CA  1 
ATOM 1084 C C   . SER A 1 143 ? 126.18  127.677 128.08  1 45.963  ? 581 SER A C   1 
ATOM 1085 O O   . SER A 1 143 ? 126.632 128.131 129.127 1 48.577  ? 581 SER A O   1 
ATOM 1086 C CB  . SER A 1 143 ? 127.632 127.379 126.063 1 48.829  ? 581 SER A CB  1 
ATOM 1087 O OG  . SER A 1 143 ? 128.779 127.235 126.892 1 51.631  ? 581 SER A OG  1 
ATOM 1088 N N   . ARG A 1 144 ? 125.321 126.662 128.025 1 43.381  ? 582 ARG A N   1 
ATOM 1089 C CA  . ARG A 1 144 ? 124.883 125.954 129.211 1 43.279  ? 582 ARG A CA  1 
ATOM 1090 C C   . ARG A 1 144 ? 124.71  124.49  128.866 1 41.259  ? 582 ARG A C   1 
ATOM 1091 O O   . ARG A 1 144 ? 124.184 124.163 127.816 1 42.025  ? 582 ARG A O   1 
ATOM 1092 C CB  . ARG A 1 144 ? 123.54  126.485 129.727 1 44.73   ? 582 ARG A CB  1 
ATOM 1093 C CG  . ARG A 1 144 ? 123.564 127.913 130.247 1 46.084  ? 582 ARG A CG  1 
ATOM 1094 C CD  . ARG A 1 144 ? 124.229 128.021 131.597 1 47.986  ? 582 ARG A CD  1 
ATOM 1095 N NE  . ARG A 1 144 ? 124.199 129.416 132.051 1 49.851  ? 582 ARG A NE  1 
ATOM 1096 C CZ  . ARG A 1 144 ? 124.986 130.38  131.607 1 53.9    ? 582 ARG A CZ  1 
ATOM 1097 N NH1 . ARG A 1 144 ? 125.969 130.105 130.769 1 54.154  ? 582 ARG A NH1 1 
ATOM 1098 N NH2 . ARG A 1 144 ? 124.811 131.621 132.025 1 55.674  ? 582 ARG A NH2 1 
ATOM 1099 N N   . VAL A 1 145 ? 125.148 123.62  129.767 1 43.488  ? 583 VAL A N   1 
ATOM 1100 C CA  . VAL A 1 145 ? 124.811 122.218 129.687 1 46.968  ? 583 VAL A CA  1 
ATOM 1101 C C   . VAL A 1 145 ? 123.451 122.023 130.355 1 49.528  ? 583 VAL A C   1 
ATOM 1102 O O   . VAL A 1 145 ? 123.256 122.39  131.511 1 55.111  ? 583 VAL A O   1 
ATOM 1103 C CB  . VAL A 1 145 ? 125.904 121.358 130.34  1 46.059  ? 583 VAL A CB  1 
ATOM 1104 C CG1 . VAL A 1 145 ? 125.554 119.885 130.303 1 44.247  ? 583 VAL A CG1 1 
ATOM 1105 C CG2 . VAL A 1 145 ? 127.248 121.577 129.674 1 47.509  ? 583 VAL A CG2 1 
ATOM 1106 N N   . LEU A 1 146 ? 122.515 121.426 129.613 1 46.202  ? 584 LEU A N   1 
ATOM 1107 C CA  . LEU A 1 146 ? 121.126 121.322 130.039 1 50.31   ? 584 LEU A CA  1 
ATOM 1108 C C   . LEU A 1 146 ? 120.841 119.949 130.631 1 48.185  ? 584 LEU A C   1 
ATOM 1109 O O   . LEU A 1 146 ? 120.027 119.824 131.535 1 59.241  ? 584 LEU A O   1 
ATOM 1110 C CB  . LEU A 1 146 ? 120.215 121.577 128.843 1 50.356  ? 584 LEU A CB  1 
ATOM 1111 C CG  . LEU A 1 146 ? 120.499 122.857 128.061 1 49.577  ? 584 LEU A CG  1 
ATOM 1112 C CD1 . LEU A 1 146 ? 119.714 122.873 126.772 1 50.69   ? 584 LEU A CD1 1 
ATOM 1113 C CD2 . LEU A 1 146 ? 120.197 124.073 128.902 1 50.685  ? 584 LEU A CD2 1 
ATOM 1114 N N   . ALA A 1 147 ? 121.485 118.918 130.09  1 47.866  ? 585 ALA A N   1 
ATOM 1115 C CA  . ALA A 1 147 ? 121.329 117.565 130.579 1 47.634  ? 585 ALA A CA  1 
ATOM 1116 C C   . ALA A 1 147 ? 122.606 116.806 130.277 1 47.343  ? 585 ALA A C   1 
ATOM 1117 O O   . ALA A 1 147 ? 123.331 117.155 129.355 1 50.059  ? 585 ALA A O   1 
ATOM 1118 C CB  . ALA A 1 147 ? 120.134 116.905 129.924 1 47.436  ? 585 ALA A CB  1 
ATOM 1119 N N   . ASP A 1 148 ? 122.849 115.747 131.037 1 49.628  ? 586 ASP A N   1 
ATOM 1120 C CA  . ASP A 1 148 ? 124.076 114.993 130.908 1 49.869  ? 586 ASP A CA  1 
ATOM 1121 C C   . ASP A 1 148 ? 123.813 113.563 131.347 1 50.185  ? 586 ASP A C   1 
ATOM 1122 O O   . ASP A 1 148 ? 123.553 113.321 132.52  1 57.489  ? 586 ASP A O   1 
ATOM 1123 C CB  . ASP A 1 148 ? 125.193 115.621 131.722 1 52.911  ? 586 ASP A CB  1 
ATOM 1124 C CG  . ASP A 1 148 ? 126.49  114.829 131.727 1 62.825  ? 586 ASP A CG  1 
ATOM 1125 O OD1 . ASP A 1 148 ? 126.569 113.823 130.982 1 68.576  ? 586 ASP A OD1 1 
ATOM 1126 O OD2 . ASP A 1 148 ? 127.397 115.199 132.496 1 72.544  ? 586 ASP A OD2 1 
ATOM 1127 N N   . GLY A 1 149 ? 123.908 112.633 130.396 1 48.862  ? 587 GLY A N   1 
ATOM 1128 C CA  . GLY A 1 149 ? 123.965 111.221 130.719 1 48.474  ? 587 GLY A CA  1 
ATOM 1129 C C   . GLY A 1 149 ? 124.029 110.381 129.453 1 49.357  ? 587 GLY A C   1 
ATOM 1130 O O   . GLY A 1 149 ? 123.242 110.59  128.539 1 51.684  ? 587 GLY A O   1 
ATOM 1131 N N   . MET A 1 150 ? 124.957 109.425 129.424 1 47.682  ? 588 MET A N   1 
ATOM 1132 C CA  . MET A 1 150 ? 125.049 108.477 128.335 1 49.949  ? 588 MET A CA  1 
ATOM 1133 C C   . MET A 1 150 ? 123.998 107.394 128.572 1 50.629  ? 588 MET A C   1 
ATOM 1134 O O   . MET A 1 150 ? 123.641 107.092 129.71  1 51.931  ? 588 MET A O   1 
ATOM 1135 C CB  . MET A 1 150 ? 126.468 107.9   128.277 1 53.573  ? 588 MET A CB  1 
ATOM 1136 C CG  . MET A 1 150 ? 126.656 106.739 127.324 1 58.153  ? 588 MET A CG  1 
ATOM 1137 S SD  . MET A 1 150 ? 126.076 107.093 125.656 1 65.315  ? 588 MET A SD  1 
ATOM 1138 C CE  . MET A 1 150 ? 126.767 108.707 125.288 1 59.114  ? 588 MET A CE  1 
ATOM 1139 N N   . THR A 1 151 ? 123.515 106.8   127.484 1 49.351  ? 589 THR A N   1 
ATOM 1140 C CA  . THR A 1 151 ? 122.415 105.859 127.601 1 50.128  ? 589 THR A CA  1 
ATOM 1141 C C   . THR A 1 151 ? 122.766 104.559 126.905 1 48.482  ? 589 THR A C   1 
ATOM 1142 O O   . THR A 1 151 ? 123.565 104.548 125.976 1 52.438  ? 589 THR A O   1 
ATOM 1143 C CB  . THR A 1 151 ? 121.131 106.451 127.021 1 50.799  ? 589 THR A CB  1 
ATOM 1144 O OG1 . THR A 1 151 ? 121.245 106.374 125.605 1 51.233  ? 589 THR A OG1 1 
ATOM 1145 C CG2 . THR A 1 151 ? 120.899 107.886 127.446 1 50.567  ? 589 THR A CG2 1 
ATOM 1146 N N   . ARG A 1 152 ? 122.15  103.476 127.371 1 48.638  ? 590 ARG A N   1 
ATOM 1147 C CA  . ARG A 1 152 ? 122.276 102.182 126.725 1 50.499  ? 590 ARG A CA  1 
ATOM 1148 C C   . ARG A 1 152 ? 120.87  101.607 126.665 1 50.929  ? 590 ARG A C   1 
ATOM 1149 O O   . ARG A 1 152 ? 120.164 101.676 127.666 1 50.761  ? 590 ARG A O   1 
ATOM 1150 C CB  . ARG A 1 152 ? 123.205 101.228 127.487 1 54.971  ? 590 ARG A CB  1 
ATOM 1151 C CG  . ARG A 1 152 ? 123.212 99.789  126.995 1 65.559  ? 590 ARG A CG  1 
ATOM 1152 C CD  . ARG A 1 152 ? 123.631 99.7    125.546 1 72.437  ? 590 ARG A CD  1 
ATOM 1153 N NE  . ARG A 1 152 ? 125.061 99.938  125.346 1 79.88   ? 590 ARG A NE  1 
ATOM 1154 C CZ  . ARG A 1 152 ? 125.627 100.049 124.146 1 88.397  ? 590 ARG A CZ  1 
ATOM 1155 N NH1 . ARG A 1 152 ? 125.011 100.669 123.143 1 87.101  ? 590 ARG A NH1 1 
ATOM 1156 N NH2 . ARG A 1 152 ? 126.855 99.595  123.982 1 90.227  ? 590 ARG A NH2 1 
ATOM 1157 N N   . GLY A 1 153 ? 120.467 101.079 125.503 1 50.348  ? 591 GLY A N   1 
ATOM 1158 C CA  . GLY A 1 153 ? 119.092 100.65  125.311 1 51.399  ? 591 GLY A CA  1 
ATOM 1159 C C   . GLY A 1 153 ? 118.979 99.156  125.031 1 50.855  ? 591 GLY A C   1 
ATOM 1160 O O   . GLY A 1 153 ? 118.669 98.796  123.896 1 50.463  ? 591 GLY A O   1 
ATOM 1161 N N   . PRO A 1 154 ? 119.179 98.26   126.03  1 46.163  ? 592 PRO A N   1 
ATOM 1162 C CA  . PRO A 1 154 ? 118.95  96.839  125.828 1 47.6    ? 592 PRO A CA  1 
ATOM 1163 C C   . PRO A 1 154 ? 117.496 96.501  125.493 1 47.068  ? 592 PRO A C   1 
ATOM 1164 O O   . PRO A 1 154 ? 116.577 97.245  125.84  1 45.984  ? 592 PRO A O   1 
ATOM 1165 C CB  . PRO A 1 154 ? 119.354 96.212  127.155 1 47.919  ? 592 PRO A CB  1 
ATOM 1166 C CG  . PRO A 1 154 ? 119.144 97.342  128.141 1 46.931  ? 592 PRO A CG  1 
ATOM 1167 C CD  . PRO A 1 154 ? 119.625 98.552  127.402 1 48.995  ? 592 PRO A CD  1 
ATOM 1168 N N   . VAL A 1 155 ? 117.323 95.354  124.832 1 44.696  ? 593 VAL A N   1 
ATOM 1169 C CA  . VAL A 1 155 ? 116.016 94.79   124.566 1 45.579  ? 593 VAL A CA  1 
ATOM 1170 C C   . VAL A 1 155 ? 115.951 93.41   125.203 1 43.912  ? 593 VAL A C   1 
ATOM 1171 O O   . VAL A 1 155 ? 116.814 92.566  124.967 1 48.906  ? 593 VAL A O   1 
ATOM 1172 C CB  . VAL A 1 155 ? 115.698 94.729  123.061 1 48.824  ? 593 VAL A CB  1 
ATOM 1173 C CG1 . VAL A 1 155 ? 116.704 93.882  122.287 1 50.153  ? 593 VAL A CG1 1 
ATOM 1174 C CG2 . VAL A 1 155 ? 114.271 94.258  122.815 1 51.478  ? 593 VAL A CG2 1 
ATOM 1175 N N   . VAL A 1 156 ? 114.892 93.2    125.989 1 43.684  ? 594 VAL A N   1 
ATOM 1176 C CA  . VAL A 1 156 ? 114.623 91.916  126.611 1 46.458  ? 594 VAL A CA  1 
ATOM 1177 C C   . VAL A 1 156 ? 113.269 91.423  126.117 1 45.246  ? 594 VAL A C   1 
ATOM 1178 O O   . VAL A 1 156 ? 112.486 92.189  125.572 1 45.802  ? 594 VAL A O   1 
ATOM 1179 C CB  . VAL A 1 156 ? 114.661 91.99   128.148 1 48.292  ? 594 VAL A CB  1 
ATOM 1180 C CG1 . VAL A 1 156 ? 115.975 92.579  128.637 1 49.093  ? 594 VAL A CG1 1 
ATOM 1181 C CG2 . VAL A 1 156 ? 113.491 92.772  128.722 1 48.758  ? 594 VAL A CG2 1 
ATOM 1182 N N   . ARG A 1 157 ? 113.015 90.133  126.3   1 45.985  ? 595 ARG A N   1 
ATOM 1183 C CA  . ARG A 1 157 ? 111.798 89.532  125.791 1 50.232  ? 595 ARG A CA  1 
ATOM 1184 C C   . ARG A 1 157 ? 111.164 88.679  126.883 1 47.562  ? 595 ARG A C   1 
ATOM 1185 O O   . ARG A 1 157 ? 111.852 87.916  127.551 1 47.714  ? 595 ARG A O   1 
ATOM 1186 C CB  . ARG A 1 157 ? 112.127 88.698  124.55  1 55.978  ? 595 ARG A CB  1 
ATOM 1187 C CG  . ARG A 1 157 ? 110.906 88.195  123.804 1 69.11   ? 595 ARG A CG  1 
ATOM 1188 C CD  . ARG A 1 157 ? 111.282 87.275  122.644 1 75.59   ? 595 ARG A CD  1 
ATOM 1189 N NE  . ARG A 1 157 ? 111.35  88.141  121.471 1 69.702  ? 595 ARG A NE  1 
ATOM 1190 C CZ  . ARG A 1 157 ? 110.609 87.975  120.401 1 70.978  ? 595 ARG A CZ  1 
ATOM 1191 N NH1 . ARG A 1 157 ? 110.511 86.788  119.832 1 80.204  ? 595 ARG A NH1 1 
ATOM 1192 N NH2 . ARG A 1 157 ? 110.128 89.048  119.814 1 67.364  ? 595 ARG A NH2 1 
ATOM 1193 N N   . LEU A 1 158 ? 109.84  88.797  127.015 1 46.259  ? 596 LEU A N   1 
ATOM 1194 C CA  . LEU A 1 158 ? 109.062 87.996  127.947 1 46.308  ? 596 LEU A CA  1 
ATOM 1195 C C   . LEU A 1 158 ? 108.198 87.008  127.179 1 46.039  ? 596 LEU A C   1 
ATOM 1196 O O   . LEU A 1 158 ? 107.99  87.163  125.983 1 49.01   ? 596 LEU A O   1 
ATOM 1197 C CB  . LEU A 1 158 ? 108.184 88.91   128.791 1 50.647  ? 596 LEU A CB  1 
ATOM 1198 C CG  . LEU A 1 158 ? 108.823 89.516  130.041 1 52.263  ? 596 LEU A CG  1 
ATOM 1199 C CD1 . LEU A 1 158 ? 109.265 88.432  131.011 1 53.05   ? 596 LEU A CD1 1 
ATOM 1200 C CD2 . LEU A 1 158 ? 109.963 90.453  129.689 1 52.92   ? 596 LEU A CD2 1 
ATOM 1201 N N   . PRO A 1 159 ? 107.659 85.959  127.833 1 50.082  ? 597 PRO A N   1 
ATOM 1202 C CA  . PRO A 1 159 ? 106.809 85.006  127.134 1 50.903  ? 597 PRO A CA  1 
ATOM 1203 C C   . PRO A 1 159 ? 105.591 85.653  126.481 1 50.555  ? 597 PRO A C   1 
ATOM 1204 O O   . PRO A 1 159 ? 105.156 85.211  125.429 1 53.722  ? 597 PRO A O   1 
ATOM 1205 C CB  . PRO A 1 159 ? 106.412 84.013  128.219 1 52.298  ? 597 PRO A CB  1 
ATOM 1206 C CG  . PRO A 1 159 ? 107.512 84.164  129.253 1 52.459  ? 597 PRO A CG  1 
ATOM 1207 C CD  . PRO A 1 159 ? 107.855 85.621  129.249 1 50.179  ? 597 PRO A CD  1 
ATOM 1208 N N   . ARG A 1 160 ? 105.028 86.68   127.123 1 51.314  ? 598 ARG A N   1 
ATOM 1209 C CA  . ARG A 1 160 ? 103.79  87.295  126.663 1 54.33   ? 598 ARG A CA  1 
ATOM 1210 C C   . ARG A 1 160 ? 103.896 88.802  126.857 1 49.702  ? 598 ARG A C   1 
ATOM 1211 O O   . ARG A 1 160 ? 104.643 89.268  127.712 1 54.047  ? 598 ARG A O   1 
ATOM 1212 C CB  . ARG A 1 160 ? 102.575 86.756  127.432 1 58.298  ? 598 ARG A CB  1 
ATOM 1213 C CG  . ARG A 1 160 ? 102.132 85.356  127.032 1 66.853  ? 598 ARG A CG  1 
ATOM 1214 C CD  . ARG A 1 160 ? 101.014 84.833  127.913 1 75.224  ? 598 ARG A CD  1 
ATOM 1215 N NE  . ARG A 1 160 ? 101.326 84.98   129.338 1 84.88   ? 598 ARG A NE  1 
ATOM 1216 C CZ  . ARG A 1 160 ? 100.506 85.475  130.26  1 99.764  ? 598 ARG A CZ  1 
ATOM 1217 N NH1 . ARG A 1 160 ? 99.25   85.775  129.964 1 104.895 ? 598 ARG A NH1 1 
ATOM 1218 N NH2 . ARG A 1 160 ? 100.94  85.64   131.501 1 97.52   ? 598 ARG A NH2 1 
ATOM 1219 N N   . ALA A 1 161 ? 103.131 89.56   126.071 1 47.316  ? 599 ALA A N   1 
ATOM 1220 C CA  . ALA A 1 161 ? 103.114 91.007  126.197 1 49.356  ? 599 ALA A CA  1 
ATOM 1221 C C   . ALA A 1 161 ? 102.568 91.437  127.558 1 49.597  ? 599 ALA A C   1 
ATOM 1222 O O   . ALA A 1 161 ? 102.947 92.49   128.061 1 51.139  ? 599 ALA A O   1 
ATOM 1223 C CB  . ALA A 1 161 ? 102.33  91.633  125.069 1 51.625  ? 599 ALA A CB  1 
ATOM 1224 N N   . CYS A 1 162 ? 101.703 90.617  128.158 1 49.866  ? 600 CYS A N   1 
ATOM 1225 C CA  . CYS A 1 162 ? 101.213 90.872  129.504 1 56.386  ? 600 CYS A CA  1 
ATOM 1226 C C   . CYS A 1 162 ? 102.363 90.839  130.51  1 52.786  ? 600 CYS A C   1 
ATOM 1227 O O   . CYS A 1 162 ? 102.424 91.673  131.412 1 56.432  ? 600 CYS A O   1 
ATOM 1228 C CB  . CYS A 1 162 ? 100.123 89.874  129.88  1 60.114  ? 600 CYS A CB  1 
ATOM 1229 S SG  . CYS A 1 162 ? 98.621  90.094  128.891 1 80.018  ? 600 CYS A SG  1 
ATOM 1230 N N   . ASP A 1 163 ? 103.279 89.88   130.346 1 52.494  ? 601 ASP A N   1 
ATOM 1231 C CA  . ASP A 1 163 ? 104.454 89.79   131.202 1 53.497  ? 601 ASP A CA  1 
ATOM 1232 C C   . ASP A 1 163 ? 105.364 90.998  131.004 1 48.51   ? 601 ASP A C   1 
ATOM 1233 O O   . ASP A 1 163 ? 105.943 91.512  131.959 1 51.74   ? 601 ASP A O   1 
ATOM 1234 C CB  . ASP A 1 163 ? 105.183 88.488  130.961 1 55.146  ? 601 ASP A CB  1 
ATOM 1235 C CG  . ASP A 1 163 ? 104.296 87.274  131.162 1 62.482  ? 601 ASP A CG  1 
ATOM 1236 O OD1 . ASP A 1 163 ? 103.558 87.259  132.171 1 69.574  ? 601 ASP A OD1 1 
ATOM 1237 O OD2 . ASP A 1 163 ? 104.359 86.361  130.328 1 68.949  ? 601 ASP A OD2 1 
ATOM 1238 N N   . SER A 1 164 ? 105.496 91.449  129.754 1 48.442  ? 602 SER A N   1 
ATOM 1239 C CA  . SER A 1 164 ? 106.287 92.635  129.471 1 47.045  ? 602 SER A CA  1 
ATOM 1240 C C   . SER A 1 164 ? 105.685 93.841  130.178 1 47.694  ? 602 SER A C   1 
ATOM 1241 O O   . SER A 1 164 ? 106.424 94.656  130.727 1 47.524  ? 602 SER A O   1 
ATOM 1242 C CB  . SER A 1 164 ? 106.414 92.888  128.003 1 51.317  ? 602 SER A CB  1 
ATOM 1243 O OG  . SER A 1 164 ? 106.906 91.732  127.351 1 57.919  ? 602 SER A OG  1 
ATOM 1244 N N   . ALA A 1 165 ? 104.349 93.954  130.15  1 47.874  ? 603 ALA A N   1 
ATOM 1245 C CA  . ALA A 1 165 ? 103.667 95.03   130.852 1 48.755  ? 603 ALA A CA  1 
ATOM 1246 C C   . ALA A 1 165 ? 103.947 94.935  132.349 1 45.581  ? 603 ALA A C   1 
ATOM 1247 O O   . ALA A 1 165 ? 104.162 95.954  132.991 1 48.016  ? 603 ALA A O   1 
ATOM 1248 C CB  . ALA A 1 165 ? 102.179 95.001  130.565 1 50.693  ? 603 ALA A CB  1 
ATOM 1249 N N   . GLU A 1 166 ? 103.929 93.722  132.903 1 45.577  ? 604 GLU A N   1 
ATOM 1250 C CA  . GLU A 1 166 ? 104.184 93.539  134.323 1 51.193  ? 604 GLU A CA  1 
ATOM 1251 C C   . GLU A 1 166 ? 105.588 94.037  134.668 1 50.669  ? 604 GLU A C   1 
ATOM 1252 O O   . GLU A 1 166 ? 105.775 94.741  135.652 1 54.61   ? 604 GLU A O   1 
ATOM 1253 C CB  . GLU A 1 166 ? 104.012 92.077  134.724 1 54.788  ? 604 GLU A CB  1 
ATOM 1254 C CG  . GLU A 1 166 ? 104.151 91.854  136.225 1 63.908  ? 604 GLU A CG  1 
ATOM 1255 C CD  . GLU A 1 166 ? 104.163 90.396  136.639 1 72.493  ? 604 GLU A CD  1 
ATOM 1256 O OE1 . GLU A 1 166 ? 103.962 89.521  135.768 1 78.606  ? 604 GLU A OE1 1 
ATOM 1257 O OE2 . GLU A 1 166 ? 104.41  90.141  137.841 1 77.895  ? 604 GLU A OE2 1 
ATOM 1258 N N   . VAL A 1 167 ? 106.578 93.677  133.85  1 49.76   ? 605 VAL A N   1 
ATOM 1259 C CA  . VAL A 1 167 ? 107.946 94.089  134.104 1 49.032  ? 605 VAL A CA  1 
ATOM 1260 C C   . VAL A 1 167 ? 108.069 95.606  134.01  1 46.975  ? 605 VAL A C   1 
ATOM 1261 O O   . VAL A 1 167 ? 108.75  96.224  134.823 1 49.249  ? 605 VAL A O   1 
ATOM 1262 C CB  . VAL A 1 167 ? 108.939 93.391  133.162 1 50.624  ? 605 VAL A CB  1 
ATOM 1263 C CG1 . VAL A 1 167 ? 110.355 93.912  133.357 1 52.169  ? 605 VAL A CG1 1 
ATOM 1264 C CG2 . VAL A 1 167 ? 108.904 91.894  133.352 1 47.647  ? 605 VAL A CG2 1 
ATOM 1265 N N   . LYS A 1 168 ? 107.422 96.206  133.014 1 46.203  ? 606 LYS A N   1 
ATOM 1266 C CA  . LYS A 1 168 ? 107.456 97.649  132.859 1 47.034  ? 606 LYS A CA  1 
ATOM 1267 C C   . LYS A 1 168 ? 106.867 98.335  134.093 1 49.134  ? 606 LYS A C   1 
ATOM 1268 O O   . LYS A 1 168 ? 107.45  99.288  134.61  1 48.3    ? 606 LYS A O   1 
ATOM 1269 C CB  . LYS A 1 168 ? 106.7   98.054  131.593 1 47.193  ? 606 LYS A CB  1 
ATOM 1270 C CG  . LYS A 1 168 ? 106.636 99.543  131.342 1 49.27   ? 606 LYS A CG  1 
ATOM 1271 C CD  . LYS A 1 168 ? 105.727 99.905  130.179 1 54.198  ? 606 LYS A CD  1 
ATOM 1272 C CE  . LYS A 1 168 ? 106.15  101.139 129.473 1 57.939  ? 606 LYS A CE  1 
ATOM 1273 N NZ  . LYS A 1 168 ? 105.978 102.32  130.305 1 61.228  ? 606 LYS A NZ  1 
ATOM 1274 N N   . ALA A 1 169 ? 105.713 97.844  134.563 1 47.723  ? 607 ALA A N   1 
ATOM 1275 C CA  . ALA A 1 169 ? 105.069 98.397  135.745 1 48.905  ? 607 ALA A CA  1 
ATOM 1276 C C   . ALA A 1 169 ? 105.993 98.282  136.956 1 46.203  ? 607 ALA A C   1 
ATOM 1277 O O   . ALA A 1 169 ? 106.097 99.217  137.739 1 48.948  ? 607 ALA A O   1 
ATOM 1278 C CB  . ALA A 1 169 ? 103.753 97.695  135.999 1 47.656  ? 607 ALA A CB  1 
ATOM 1279 N N   . TRP A 1 170 ? 106.644 97.13   137.114 1 48.386  ? 608 TRP A N   1 
ATOM 1280 C CA  . TRP A 1 170 ? 107.528 96.907  138.246 1 50.625  ? 608 TRP A CA  1 
ATOM 1281 C C   . TRP A 1 170 ? 108.722 97.854  138.191 1 53.132  ? 608 TRP A C   1 
ATOM 1282 O O   . TRP A 1 170 ? 109.13  98.38   139.218 1 54.385  ? 608 TRP A O   1 
ATOM 1283 C CB  . TRP A 1 170 ? 107.979 95.449  138.273 1 55.081  ? 608 TRP A CB  1 
ATOM 1284 C CG  . TRP A 1 170 ? 108.792 95.081  139.481 1 64.813  ? 608 TRP A CG  1 
ATOM 1285 C CD1 . TRP A 1 170 ? 108.336 94.64   140.688 1 69.485  ? 608 TRP A CD1 1 
ATOM 1286 C CD2 . TRP A 1 170 ? 110.229 95.086  139.57  1 67.299  ? 608 TRP A CD2 1 
ATOM 1287 N NE1 . TRP A 1 170 ? 109.387 94.381  141.525 1 71.561  ? 608 TRP A NE1 1 
ATOM 1288 C CE2 . TRP A 1 170 ? 110.559 94.641  140.868 1 69.609  ? 608 TRP A CE2 1 
ATOM 1289 C CE3 . TRP A 1 170 ? 111.256 95.424  138.685 1 66.386  ? 608 TRP A CE3 1 
ATOM 1290 C CZ2 . TRP A 1 170 ? 111.878 94.528  141.299 1 70.218  ? 608 TRP A CZ2 1 
ATOM 1291 C CZ3 . TRP A 1 170 ? 112.559 95.299  139.111 1 68.952  ? 608 TRP A CZ3 1 
ATOM 1292 C CH2 . TRP A 1 170 ? 112.865 94.86   140.399 1 67.814  ? 608 TRP A CH2 1 
ATOM 1293 N N   . LEU A 1 171 ? 109.267 98.087  136.993 1 54.228  ? 609 LEU A N   1 
ATOM 1294 C CA  . LEU A 1 171 ? 110.363 99.029  136.823 1 51.901  ? 609 LEU A CA  1 
ATOM 1295 C C   . LEU A 1 171 ? 109.909 100.448 137.144 1 54.523  ? 609 LEU A C   1 
ATOM 1296 O O   . LEU A 1 171 ? 110.721 101.285 137.511 1 57.309  ? 609 LEU A O   1 
ATOM 1297 C CB  . LEU A 1 171 ? 110.939 98.956  135.411 1 50.218  ? 609 LEU A CB  1 
ATOM 1298 C CG  . LEU A 1 171 ? 111.783 97.72   135.093 1 51.397  ? 609 LEU A CG  1 
ATOM 1299 C CD1 . LEU A 1 171 ? 112.072 97.635  133.605 1 55.125  ? 609 LEU A CD1 1 
ATOM 1300 C CD2 . LEU A 1 171 ? 113.074 97.733  135.883 1 53.219  ? 609 LEU A CD2 1 
ATOM 1301 N N   . GLU A 1 172 ? 108.619 100.739 136.989 1 57.484  ? 610 GLU A N   1 
ATOM 1302 C CA  . GLU A 1 172 ? 108.118 102.085 137.22  1 60.772  ? 610 GLU A CA  1 
ATOM 1303 C C   . GLU A 1 172 ? 107.871 102.386 138.697 1 56.589  ? 610 GLU A C   1 
ATOM 1304 O O   . GLU A 1 172 ? 107.712 103.55  139.047 1 62.204  ? 610 GLU A O   1 
ATOM 1305 C CB  . GLU A 1 172 ? 106.821 102.317 136.452 1 68.787  ? 610 GLU A CB  1 
ATOM 1306 C CG  . GLU A 1 172 ? 107     103.258 135.268 1 77.469  ? 610 GLU A CG  1 
ATOM 1307 C CD  . GLU A 1 172 ? 105.989 103.015 134.165 1 83.341  ? 610 GLU A CD  1 
ATOM 1308 O OE1 . GLU A 1 172 ? 106.254 103.485 133.041 1 87.254  ? 610 GLU A OE1 1 
ATOM 1309 O OE2 . GLU A 1 172 ? 104.948 102.365 134.409 1 90.862  ? 610 GLU A OE2 1 
ATOM 1310 N N   . THR A 1 173 ? 107.829 101.366 139.559 1 56.139  ? 611 THR A N   1 
ATOM 1311 C CA  . THR A 1 173 ? 107.63  101.6   140.985 1 59.691  ? 611 THR A CA  1 
ATOM 1312 C C   . THR A 1 173 ? 108.944 102.056 141.618 1 62.295  ? 611 THR A C   1 
ATOM 1313 O O   . THR A 1 173 ? 110.02  101.869 141.053 1 62.926  ? 611 THR A O   1 
ATOM 1314 C CB  . THR A 1 173 ? 107.096 100.355 141.69  1 56.397  ? 611 THR A CB  1 
ATOM 1315 O OG1 . THR A 1 173 ? 108.144 99.4    141.793 1 56.365  ? 611 THR A OG1 1 
ATOM 1316 C CG2 . THR A 1 173 ? 105.919 99.726  140.971 1 55.984  ? 611 THR A CG2 1 
ATOM 1317 N N   . SER A 1 174 ? 108.845 102.633 142.82  1 64.893  ? 612 SER A N   1 
ATOM 1318 C CA  . SER A 1 174 ? 110.007 103.166 143.509 1 65.7    ? 612 SER A CA  1 
ATOM 1319 C C   . SER A 1 174 ? 110.91  102.032 143.991 1 63.179  ? 612 SER A C   1 
ATOM 1320 O O   . SER A 1 174 ? 112.131 102.17  143.954 1 70.499  ? 612 SER A O   1 
ATOM 1321 C CB  . SER A 1 174 ? 109.599 104.066 144.642 1 69.689  ? 612 SER A CB  1 
ATOM 1322 O OG  . SER A 1 174 ? 109.214 103.302 145.776 1 75.209  ? 612 SER A OG  1 
ATOM 1323 N N   . GLU A 1 175 ? 110.309 100.911 144.403 1 62.561  ? 613 GLU A N   1 
ATOM 1324 C CA  . GLU A 1 175 ? 111.061 99.804  144.97  1 68.196  ? 613 GLU A CA  1 
ATOM 1325 C C   . GLU A 1 175 ? 111.864 99.104  143.875 1 66.289  ? 613 GLU A C   1 
ATOM 1326 O O   . GLU A 1 175 ? 113.046 98.823  144.051 1 70.767  ? 613 GLU A O   1 
ATOM 1327 C CB  . GLU A 1 175 ? 110.145 98.8    145.67  1 73.316  ? 613 GLU A CB  1 
ATOM 1328 C CG  . GLU A 1 175 ? 109.197 99.443  146.677 1 81.286  ? 613 GLU A CG  1 
ATOM 1329 C CD  . GLU A 1 175 ? 107.938 100.02  146.051 1 92.104  ? 613 GLU A CD  1 
ATOM 1330 O OE1 . GLU A 1 175 ? 107.233 99.273  145.337 1 96.004  ? 613 GLU A OE1 1 
ATOM 1331 O OE2 . GLU A 1 175 ? 107.658 101.216 146.272 1 93.467  ? 613 GLU A OE2 1 
ATOM 1332 N N   . GLY A 1 176 ? 111.205 98.796  142.755 1 63.249  ? 614 GLY A N   1 
ATOM 1333 C CA  . GLY A 1 176 ? 111.869 98.16   141.631 1 58.645  ? 614 GLY A CA  1 
ATOM 1334 C C   . GLY A 1 176 ? 112.998 99.024  141.076 1 54.997  ? 614 GLY A C   1 
ATOM 1335 O O   . GLY A 1 176 ? 114.103 98.546  140.835 1 57.315  ? 614 GLY A O   1 
ATOM 1336 N N   . PHE A 1 177 ? 112.719 100.313 140.909 1 51.999  ? 615 PHE A N   1 
ATOM 1337 C CA  . PHE A 1 177 ? 113.74  101.227 140.44  1 59.486  ? 615 PHE A CA  1 
ATOM 1338 C C   . PHE A 1 177 ? 114.899 101.286 141.435 1 62.675  ? 615 PHE A C   1 
ATOM 1339 O O   . PHE A 1 177 ? 116.047 101.387 141.011 1 66.211  ? 615 PHE A O   1 
ATOM 1340 C CB  . PHE A 1 177 ? 113.19  102.628 140.191 1 55.714  ? 615 PHE A CB  1 
ATOM 1341 C CG  . PHE A 1 177 ? 114.259 103.579 139.685 1 58.58   ? 615 PHE A CG  1 
ATOM 1342 C CD1 . PHE A 1 177 ? 114.688 103.531 138.364 1 60.109  ? 615 PHE A CD1 1 
ATOM 1343 C CD2 . PHE A 1 177 ? 114.866 104.481 140.546 1 61.856  ? 615 PHE A CD2 1 
ATOM 1344 C CE1 . PHE A 1 177 ? 115.682 104.383 137.913 1 60.169  ? 615 PHE A CE1 1 
ATOM 1345 C CE2 . PHE A 1 177 ? 115.857 105.334 140.09  1 60.912  ? 615 PHE A CE2 1 
ATOM 1346 C CZ  . PHE A 1 177 ? 116.26  105.285 138.772 1 61.858  ? 615 PHE A CZ  1 
ATOM 1347 N N   . ALA A 1 178 ? 114.604 101.237 142.74  1 60.655  ? 616 ALA A N   1 
ATOM 1348 C CA  . ALA A 1 178 ? 115.652 101.275 143.749 1 60.176  ? 616 ALA A CA  1 
ATOM 1349 C C   . ALA A 1 178 ? 116.559 100.056 143.622 1 56.627  ? 616 ALA A C   1 
ATOM 1350 O O   . ALA A 1 178 ? 117.777 100.189 143.679 1 65.822  ? 616 ALA A O   1 
ATOM 1351 C CB  . ALA A 1 178 ? 115.054 101.381 145.134 1 60.599  ? 616 ALA A CB  1 
ATOM 1352 N N   . VAL A 1 179 ? 115.965 98.874  143.445 1 56.183  ? 617 VAL A N   1 
ATOM 1353 C CA  . VAL A 1 179 ? 116.733 97.646  143.337 1 59.587  ? 617 VAL A CA  1 
ATOM 1354 C C   . VAL A 1 179 ? 117.638 97.716  142.111 1 59.092  ? 617 VAL A C   1 
ATOM 1355 O O   . VAL A 1 179 ? 118.823 97.402  142.188 1 63.916  ? 617 VAL A O   1 
ATOM 1356 C CB  . VAL A 1 179 ? 115.801 96.419  143.297 1 62.044  ? 617 VAL A CB  1 
ATOM 1357 C CG1 . VAL A 1 179 ? 116.504 95.183  142.763 1 62.854  ? 617 VAL A CG1 1 
ATOM 1358 C CG2 . VAL A 1 179 ? 115.211 96.133  144.669 1 66.061  ? 617 VAL A CG2 1 
ATOM 1359 N N   . ILE A 1 180 ? 117.064 98.132  140.98  1 58.594  ? 618 ILE A N   1 
ATOM 1360 C CA  . ILE A 1 180 ? 117.799 98.212  139.729 1 57.512  ? 618 ILE A CA  1 
ATOM 1361 C C   . ILE A 1 180 ? 118.912 99.25   139.85  1 54.24   ? 618 ILE A C   1 
ATOM 1362 O O   . ILE A 1 180 ? 120.017 99.023  139.377 1 55.955  ? 618 ILE A O   1 
ATOM 1363 C CB  . ILE A 1 180 ? 116.842 98.515  138.561 1 57.732  ? 618 ILE A CB  1 
ATOM 1364 C CG1 . ILE A 1 180 ? 115.851 97.389  138.353 1 55.736  ? 618 ILE A CG1 1 
ATOM 1365 C CG2 . ILE A 1 180 ? 117.607 98.82   137.277 1 57.554  ? 618 ILE A CG2 1 
ATOM 1366 C CD1 . ILE A 1 180 ? 116.481 96.017  138.243 1 57.285  ? 618 ILE A CD1 1 
ATOM 1367 N N   . LYS A 1 181 ? 118.608 100.385 140.476 1 54.156  ? 619 LYS A N   1 
ATOM 1368 C CA  . LYS A 1 181 ? 119.59  101.439 140.662 1 59.388  ? 619 LYS A CA  1 
ATOM 1369 C C   . LYS A 1 181 ? 120.761 100.949 141.512 1 60.352  ? 619 LYS A C   1 
ATOM 1370 O O   . LYS A 1 181 ? 121.907 101.25  141.199 1 60.662  ? 619 LYS A O   1 
ATOM 1371 C CB  . LYS A 1 181 ? 118.925 102.661 141.293 1 59.733  ? 619 LYS A CB  1 
ATOM 1372 C CG  . LYS A 1 181 ? 119.879 103.773 141.659 1 63.842  ? 619 LYS A CG  1 
ATOM 1373 C CD  . LYS A 1 181 ? 119.181 105.111 141.842 1 65.532  ? 619 LYS A CD  1 
ATOM 1374 C CE  . LYS A 1 181 ? 120.1   106.18  142.337 1 69.726  ? 619 LYS A CE  1 
ATOM 1375 N NZ  . LYS A 1 181 ? 121.23  106.418 141.433 1 72.805  ? 619 LYS A NZ  1 
ATOM 1376 N N   . GLU A 1 182 ? 120.484 100.198 142.58  1 61.166  ? 620 GLU A N   1 
ATOM 1377 C CA  . GLU A 1 182 ? 121.545 99.682  143.427 1 63.505  ? 620 GLU A CA  1 
ATOM 1378 C C   . GLU A 1 182 ? 122.456 98.764  142.617 1 58.761  ? 620 GLU A C   1 
ATOM 1379 O O   . GLU A 1 182 ? 123.68  98.908  142.651 1 65.764  ? 620 GLU A O   1 
ATOM 1380 C CB  . GLU A 1 182 ? 120.959 98.966  144.643 1 68.732  ? 620 GLU A CB  1 
ATOM 1381 C CG  . GLU A 1 182 ? 121.899 97.914  145.224 1 77.147  ? 620 GLU A CG  1 
ATOM 1382 C CD  . GLU A 1 182 ? 121.562 97.515  146.65  1 89.214  ? 620 GLU A CD  1 
ATOM 1383 O OE1 . GLU A 1 182 ? 120.363 97.296  146.931 1 90.147  ? 620 GLU A OE1 1 
ATOM 1384 O OE2 . GLU A 1 182 ? 122.497 97.401  147.477 1 99.411  ? 620 GLU A OE2 1 
ATOM 1385 N N   . ALA A 1 183 ? 121.847 97.812  141.906 1 56.256  ? 621 ALA A N   1 
ATOM 1386 C CA  . ALA A 1 183 ? 122.6   96.855  141.115 1 56.819  ? 621 ALA A CA  1 
ATOM 1387 C C   . ALA A 1 183 ? 123.458 97.586  140.084 1 57.38   ? 621 ALA A C   1 
ATOM 1388 O O   . ALA A 1 183 ? 124.627 97.265  139.914 1 65.081  ? 621 ALA A O   1 
ATOM 1389 C CB  . ALA A 1 183 ? 121.668 95.857  140.468 1 55.135  ? 621 ALA A CB  1 
ATOM 1390 N N   . PHE A 1 184 ? 122.877 98.583  139.416 1 54.243  ? 622 PHE A N   1 
ATOM 1391 C CA  . PHE A 1 184 ? 123.57  99.31   138.368 1 57.294  ? 622 PHE A CA  1 
ATOM 1392 C C   . PHE A 1 184 ? 124.738 100.1   138.952 1 59.722  ? 622 PHE A C   1 
ATOM 1393 O O   . PHE A 1 184 ? 125.826 100.111 138.392 1 61.814  ? 622 PHE A O   1 
ATOM 1394 C CB  . PHE A 1 184 ? 122.576 100.24  137.676 1 53.687  ? 622 PHE A CB  1 
ATOM 1395 C CG  . PHE A 1 184 ? 123.163 101.049 136.536 1 52.42   ? 622 PHE A CG  1 
ATOM 1396 C CD1 . PHE A 1 184 ? 123.792 102.266 136.764 1 52.246  ? 622 PHE A CD1 1 
ATOM 1397 C CD2 . PHE A 1 184 ? 123.072 100.574 135.237 1 52.823  ? 622 PHE A CD2 1 
ATOM 1398 C CE1 . PHE A 1 184 ? 124.32  102.992 135.712 1 55.813  ? 622 PHE A CE1 1 
ATOM 1399 C CE2 . PHE A 1 184 ? 123.595 101.304 134.183 1 54.273  ? 622 PHE A CE2 1 
ATOM 1400 C CZ  . PHE A 1 184 ? 124.212 102.514 134.418 1 53.289  ? 622 PHE A CZ  1 
ATOM 1401 N N   . ASP A 1 185 ? 124.499 100.762 140.084 1 63.007  ? 623 ASP A N   1 
ATOM 1402 C CA  . ASP A 1 185 ? 125.474 101.662 140.674 1 65.548  ? 623 ASP A CA  1 
ATOM 1403 C C   . ASP A 1 185 ? 126.635 100.911 141.323 1 65.259  ? 623 ASP A C   1 
ATOM 1404 O O   . ASP A 1 185 ? 127.704 101.481 141.503 1 76.495  ? 623 ASP A O   1 
ATOM 1405 C CB  . ASP A 1 185 ? 124.805 102.605 141.652 1 62.992  ? 623 ASP A CB  1 
ATOM 1406 C CG  . ASP A 1 185 ? 123.88  103.623 141     1 68.812  ? 623 ASP A CG  1 
ATOM 1407 O OD1 . ASP A 1 185 ? 123.426 104.541 141.703 1 66.924  ? 623 ASP A OD1 1 
ATOM 1408 O OD2 . ASP A 1 185 ? 123.607 103.502 139.786 1 68.411  ? 623 ASP A OD2 1 
ATOM 1409 N N   . SER A 1 186 ? 126.452 99.63   141.637 1 68.949  ? 624 SER A N   1 
ATOM 1410 C CA  . SER A 1 186 ? 127.497 98.869  142.303 1 70.692  ? 624 SER A CA  1 
ATOM 1411 C C   . SER A 1 186 ? 128.708 98.624  141.396 1 72.178  ? 624 SER A C   1 
ATOM 1412 O O   . SER A 1 186 ? 129.741 98.178  141.887 1 79.693  ? 624 SER A O   1 
ATOM 1413 C CB  . SER A 1 186 ? 126.956 97.563  142.815 1 72.78   ? 624 SER A CB  1 
ATOM 1414 O OG  . SER A 1 186 ? 127.035 96.557  141.814 1 77.406  ? 624 SER A OG  1 
ATOM 1415 N N   . THR A 1 187 ? 128.598 98.893  140.085 1 70.523  ? 625 THR A N   1 
ATOM 1416 C CA  . THR A 1 187 ? 129.604 98.432  139.134 1 69.626  ? 625 THR A CA  1 
ATOM 1417 C C   . THR A 1 187 ? 130.728 99.446  138.929 1 65.577  ? 625 THR A C   1 
ATOM 1418 O O   . THR A 1 187 ? 131.737 99.108  138.314 1 70.141  ? 625 THR A O   1 
ATOM 1419 C CB  . THR A 1 187 ? 128.979 98.098  137.781 1 66.819  ? 625 THR A CB  1 
ATOM 1420 O OG1 . THR A 1 187 ? 128.388 99.289  137.272 1 61.776  ? 625 THR A OG1 1 
ATOM 1421 C CG2 . THR A 1 187 ? 127.966 96.978  137.885 1 65.967  ? 625 THR A CG2 1 
ATOM 1422 N N   . SER A 1 188 ? 130.55  100.683 139.399 1 63.351  ? 626 SER A N   1 
ATOM 1423 C CA  . SER A 1 188 ? 131.563 101.706 139.222 1 67.145  ? 626 SER A CA  1 
ATOM 1424 C C   . SER A 1 188 ? 131.209 102.928 140.058 1 66.726  ? 626 SER A C   1 
ATOM 1425 O O   . SER A 1 188 ? 130.059 103.093 140.447 1 70.169  ? 626 SER A O   1 
ATOM 1426 C CB  . SER A 1 188 ? 131.722 102.049 137.767 1 72.556  ? 626 SER A CB  1 
ATOM 1427 O OG  . SER A 1 188 ? 131.709 103.454 137.566 1 73.514  ? 626 SER A OG  1 
ATOM 1428 N N   . ARG A 1 189 ? 132.201 103.785 140.317 1 68.15   ? 627 ARG A N   1 
ATOM 1429 C CA  . ARG A 1 189 ? 132.014 104.922 141.206 1 70.612  ? 627 ARG A CA  1 
ATOM 1430 C C   . ARG A 1 189 ? 131.235 106.041 140.517 1 68.744  ? 627 ARG A C   1 
ATOM 1431 O O   . ARG A 1 189 ? 130.674 106.898 141.192 1 68.714  ? 627 ARG A O   1 
ATOM 1432 C CB  . ARG A 1 189 ? 133.355 105.474 141.702 1 80.344  ? 627 ARG A CB  1 
ATOM 1433 C CG  . ARG A 1 189 ? 134.257 106.022 140.605 1 87.641  ? 627 ARG A CG  1 
ATOM 1434 C CD  . ARG A 1 189 ? 135.638 106.374 141.125 1 95.408  ? 627 ARG A CD  1 
ATOM 1435 N NE  . ARG A 1 189 ? 135.713 107.776 141.55  1 101.794 ? 627 ARG A NE  1 
ATOM 1436 C CZ  . ARG A 1 189 ? 136.594 108.672 141.11  1 109.154 ? 627 ARG A CZ  1 
ATOM 1437 N NH1 . ARG A 1 189 ? 137.547 108.326 140.257 1 110.249 ? 627 ARG A NH1 1 
ATOM 1438 N NH2 . ARG A 1 189 ? 136.526 109.922 141.538 1 109.259 ? 627 ARG A NH2 1 
ATOM 1439 N N   . PHE A 1 190 ? 131.238 106.067 139.18  1 67.213  ? 628 PHE A N   1 
ATOM 1440 C CA  . PHE A 1 190 ? 130.517 107.098 138.448 1 71.037  ? 628 PHE A CA  1 
ATOM 1441 C C   . PHE A 1 190 ? 129.133 106.619 138.006 1 67.083  ? 628 PHE A C   1 
ATOM 1442 O O   . PHE A 1 190 ? 128.344 107.426 137.521 1 68.23   ? 628 PHE A O   1 
ATOM 1443 C CB  . PHE A 1 190 ? 131.33  107.539 137.228 1 73.966  ? 628 PHE A CB  1 
ATOM 1444 C CG  . PHE A 1 190 ? 132.66  108.178 137.575 1 76.788  ? 628 PHE A CG  1 
ATOM 1445 C CD1 . PHE A 1 190 ? 132.725 109.236 138.47  1 79.707  ? 628 PHE A CD1 1 
ATOM 1446 C CD2 . PHE A 1 190 ? 133.841 107.697 137.025 1 78.204  ? 628 PHE A CD2 1 
ATOM 1447 C CE1 . PHE A 1 190 ? 133.942 109.816 138.78  1 80.432  ? 628 PHE A CE1 1 
ATOM 1448 C CE2 . PHE A 1 190 ? 135.057 108.278 137.347 1 77.474  ? 628 PHE A CE2 1 
ATOM 1449 C CZ  . PHE A 1 190 ? 135.104 109.334 138.225 1 78.479  ? 628 PHE A CZ  1 
ATOM 1450 N N   . ALA A 1 191 ? 128.838 105.32  138.154 1 63.91   ? 629 ALA A N   1 
ATOM 1451 C CA  . ALA A 1 191 ? 127.567 104.767 137.705 1 63.519  ? 629 ALA A CA  1 
ATOM 1452 C C   . ALA A 1 191 ? 126.45  105.172 138.661 1 65.631  ? 629 ALA A C   1 
ATOM 1453 O O   . ALA A 1 191 ? 126.317 104.591 139.728 1 68.829  ? 629 ALA A O   1 
ATOM 1454 C CB  . ALA A 1 191 ? 127.664 103.265 137.598 1 63.291  ? 629 ALA A CB  1 
ATOM 1455 N N   . ARG A 1 192 ? 125.667 106.184 138.275 1 62.453  ? 630 ARG A N   1 
ATOM 1456 C CA  . ARG A 1 192 ? 124.573 106.684 139.088 1 63.288  ? 630 ARG A CA  1 
ATOM 1457 C C   . ARG A 1 192 ? 123.314 106.715 138.226 1 61.527  ? 630 ARG A C   1 
ATOM 1458 O O   . ARG A 1 192 ? 123.056 107.685 137.513 1 60.023  ? 630 ARG A O   1 
ATOM 1459 C CB  . ARG A 1 192 ? 124.897 108.062 139.681 1 68.307  ? 630 ARG A CB  1 
ATOM 1460 C CG  . ARG A 1 192 ? 126.071 108.09  140.651 1 77.432  ? 630 ARG A CG  1 
ATOM 1461 C CD  . ARG A 1 192 ? 125.942 107.054 141.766 1 83.121  ? 630 ARG A CD  1 
ATOM 1462 N NE  . ARG A 1 192 ? 126.878 107.252 142.877 1 91.966  ? 630 ARG A NE  1 
ATOM 1463 C CZ  . ARG A 1 192 ? 126.861 108.294 143.704 1 104.497 ? 630 ARG A CZ  1 
ATOM 1464 N NH1 . ARG A 1 192 ? 125.965 109.257 143.547 1 105.731 ? 630 ARG A NH1 1 
ATOM 1465 N NH2 . ARG A 1 192 ? 127.741 108.368 144.689 1 107.201 ? 630 ARG A NH2 1 
ATOM 1466 N N   . LEU A 1 193 ? 122.543 105.629 138.294 1 56.607  ? 631 LEU A N   1 
ATOM 1467 C CA  . LEU A 1 193 ? 121.385 105.451 137.437 1 54.779  ? 631 LEU A CA  1 
ATOM 1468 C C   . LEU A 1 193 ? 120.391 106.593 137.632 1 56.946  ? 631 LEU A C   1 
ATOM 1469 O O   . LEU A 1 193 ? 120.024 106.922 138.752 1 64.163  ? 631 LEU A O   1 
ATOM 1470 C CB  . LEU A 1 193 ? 120.735 104.104 137.741 1 55.517  ? 631 LEU A CB  1 
ATOM 1471 C CG  . LEU A 1 193 ? 119.681 103.612 136.742 1 56.609  ? 631 LEU A CG  1 
ATOM 1472 C CD1 . LEU A 1 193 ? 120.276 103.505 135.351 1 57.636  ? 631 LEU A CD1 1 
ATOM 1473 C CD2 . LEU A 1 193 ? 119.124 102.264 137.167 1 54.808  ? 631 LEU A CD2 1 
ATOM 1474 N N   . GLN A 1 194 ? 119.966 107.191 136.518 1 59.298  ? 632 GLN A N   1 
ATOM 1475 C CA  . GLN A 1 194 ? 118.89  108.167 136.502 1 61.996  ? 632 GLN A CA  1 
ATOM 1476 C C   . GLN A 1 194 ? 117.605 107.479 136.037 1 58.752  ? 632 GLN A C   1 
ATOM 1477 O O   . GLN A 1 194 ? 117.567 106.276 135.796 1 60.066  ? 632 GLN A O   1 
ATOM 1478 C CB  . GLN A 1 194 ? 119.237 109.321 135.563 1 63.716  ? 632 GLN A CB  1 
ATOM 1479 C CG  . GLN A 1 194 ? 120.635 109.897 135.754 1 70.09   ? 632 GLN A CG  1 
ATOM 1480 C CD  . GLN A 1 194 ? 120.998 110.886 134.665 1 75.037  ? 632 GLN A CD  1 
ATOM 1481 O OE1 . GLN A 1 194 ? 120.19  111.21  133.788 1 79.537  ? 632 GLN A OE1 1 
ATOM 1482 N NE2 . GLN A 1 194 ? 122.224 111.381 134.701 1 77.393  ? 632 GLN A NE2 1 
ATOM 1483 N N   . LYS A 1 195 ? 116.531 108.25  135.915 1 65.881  ? 633 LYS A N   1 
ATOM 1484 C CA  . LYS A 1 195 ? 115.225 107.672 135.65  1 76.215  ? 633 LYS A CA  1 
ATOM 1485 C C   . LYS A 1 195 ? 115.262 106.841 134.371 1 72.239  ? 633 LYS A C   1 
ATOM 1486 O O   . LYS A 1 195 ? 115.871 107.249 133.385 1 74.884  ? 633 LYS A O   1 
ATOM 1487 C CB  . LYS A 1 195 ? 114.15  108.757 135.551 1 86.35   ? 633 LYS A CB  1 
ATOM 1488 C CG  . LYS A 1 195 ? 114.222 109.629 134.307 1 96.254  ? 633 LYS A CG  1 
ATOM 1489 C CD  . LYS A 1 195 ? 113.105 110.664 134.217 1 106.163 ? 633 LYS A CD  1 
ATOM 1490 C CE  . LYS A 1 195 ? 112.809 111.358 135.515 1 111.25  ? 633 LYS A CE  1 
ATOM 1491 N NZ  . LYS A 1 195 ? 114.002 111.944 136.135 1 113.648 ? 633 LYS A NZ  1 
ATOM 1492 N N   . LEU A 1 196 ? 114.583 105.687 134.413 1 65.909  ? 634 LEU A N   1 
ATOM 1493 C CA  . LEU A 1 196 ? 114.524 104.756 133.299 1 62.075  ? 634 LEU A CA  1 
ATOM 1494 C C   . LEU A 1 196 ? 113.439 105.184 132.317 1 62.038  ? 634 LEU A C   1 
ATOM 1495 O O   . LEU A 1 196 ? 112.455 105.821 132.688 1 68.134  ? 634 LEU A O   1 
ATOM 1496 C CB  . LEU A 1 196 ? 114.251 103.34  133.79  1 59.762  ? 634 LEU A CB  1 
ATOM 1497 C CG  . LEU A 1 196 ? 115.44  102.584 134.383 1 62.696  ? 634 LEU A CG  1 
ATOM 1498 C CD1 . LEU A 1 196 ? 114.942 101.301 135.021 1 63.431  ? 634 LEU A CD1 1 
ATOM 1499 C CD2 . LEU A 1 196 ? 116.5   102.291 133.328 1 65.928  ? 634 LEU A CD2 1 
ATOM 1500 N N   . HIS A 1 197 ? 113.64  104.804 131.056 1 58.485  ? 635 HIS A N   1 
ATOM 1501 C CA  . HIS A 1 197 ? 112.663 105.022 130.009 1 55.344  ? 635 HIS A CA  1 
ATOM 1502 C C   . HIS A 1 197 ? 112.422 103.692 129.317 1 54.373  ? 635 HIS A C   1 
ATOM 1503 O O   . HIS A 1 197 ? 113.348 103.083 128.799 1 57.928  ? 635 HIS A O   1 
ATOM 1504 C CB  . HIS A 1 197 ? 113.123 106.1   129.027 1 60.493  ? 635 HIS A CB  1 
ATOM 1505 C CG  . HIS A 1 197 ? 112.035 106.553 128.113 1 72.816  ? 635 HIS A CG  1 
ATOM 1506 N ND1 . HIS A 1 197 ? 111.39  105.711 127.232 1 76.252  ? 635 HIS A ND1 1 
ATOM 1507 C CD2 . HIS A 1 197 ? 111.43  107.745 127.994 1 78.803  ? 635 HIS A CD2 1 
ATOM 1508 C CE1 . HIS A 1 197 ? 110.459 106.393 126.579 1 77.348  ? 635 HIS A CE1 1 
ATOM 1509 N NE2 . HIS A 1 197 ? 110.466 107.63  127.024 1 78.763  ? 635 HIS A NE2 1 
ATOM 1510 N N   . THR A 1 198 ? 111.174 103.234 129.347 1 51.773  ? 636 THR A N   1 
ATOM 1511 C CA  . THR A 1 198 ? 110.822 101.933 128.813 1 50.956  ? 636 THR A CA  1 
ATOM 1512 C C   . THR A 1 198 ? 109.893 102.123 127.624 1 50.287  ? 636 THR A C   1 
ATOM 1513 O O   . THR A 1 198 ? 109.191 103.125 127.511 1 54.778  ? 636 THR A O   1 
ATOM 1514 C CB  . THR A 1 198 ? 110.181 101.049 129.882 1 55.405  ? 636 THR A CB  1 
ATOM 1515 O OG1 . THR A 1 198 ? 109.225 101.836 130.59  1 59.223  ? 636 THR A OG1 1 
ATOM 1516 C CG2 . THR A 1 198 ? 111.216 100.486 130.839 1 55.117  ? 636 THR A CG2 1 
ATOM 1517 N N   . SER A 1 199 ? 109.907 101.131 126.736 1 49.638  ? 637 SER A N   1 
ATOM 1518 C CA  . SER A 1 199 ? 108.994 101.091 125.614 1 47.045  ? 637 SER A CA  1 
ATOM 1519 C C   . SER A 1 199 ? 108.678 99.639  125.316 1 46.221  ? 637 SER A C   1 
ATOM 1520 O O   . SER A 1 199 ? 109.574 98.813  125.261 1 48.128  ? 637 SER A O   1 
ATOM 1521 C CB  . SER A 1 199 ? 109.583 101.798 124.424 1 50.981  ? 637 SER A CB  1 
ATOM 1522 O OG  . SER A 1 199 ? 108.733 101.738 123.29  1 57.306  ? 637 SER A OG  1 
ATOM 1523 N N   . ILE A 1 200 ? 107.395 99.323  125.17  1 45.213  ? 638 ILE A N   1 
ATOM 1524 C CA  . ILE A 1 200 ? 106.992 97.966  124.876 1 46.553  ? 638 ILE A CA  1 
ATOM 1525 C C   . ILE A 1 200 ? 106.685 97.875  123.386 1 43.184  ? 638 ILE A C   1 
ATOM 1526 O O   . ILE A 1 200 ? 106.171 98.81   122.784 1 43.154  ? 638 ILE A O   1 
ATOM 1527 C CB  . ILE A 1 200 ? 105.818 97.531  125.774 1 50.89   ? 638 ILE A CB  1 
ATOM 1528 C CG1 . ILE A 1 200 ? 106.337 97.011  127.119 1 55.279  ? 638 ILE A CG1 1 
ATOM 1529 C CG2 . ILE A 1 200 ? 104.947 96.492  125.077 1 48.025  ? 638 ILE A CG2 1 
ATOM 1530 C CD1 . ILE A 1 200 ? 105.283 96.452  128.047 1 59.968  ? 638 ILE A CD1 1 
ATOM 1531 N N   . ALA A 1 201 ? 107.011 96.732  122.791 1 39.58   ? 639 ALA A N   1 
ATOM 1532 C CA  . ALA A 1 201 ? 106.464 96.366  121.498 1 42.503  ? 639 ALA A CA  1 
ATOM 1533 C C   . ALA A 1 201 ? 106.144 94.884  121.535 1 42.22   ? 639 ALA A C   1 
ATOM 1534 O O   . ALA A 1 201 ? 107.043 94.059  121.451 1 42.411  ? 639 ALA A O   1 
ATOM 1535 C CB  . ALA A 1 201 ? 107.422 96.708  120.375 1 46.201  ? 639 ALA A CB  1 
ATOM 1536 N N   . GLY A 1 202 ? 104.866 94.56   121.719 1 42.069  ? 640 GLY A N   1 
ATOM 1537 C CA  . GLY A 1 202 ? 104.493 93.183  121.947 1 44.128  ? 640 GLY A CA  1 
ATOM 1538 C C   . GLY A 1 202 ? 105.183 92.675  123.204 1 45.237  ? 640 GLY A C   1 
ATOM 1539 O O   . GLY A 1 202 ? 105.144 93.325  124.24  1 50.307  ? 640 GLY A O   1 
ATOM 1540 N N   . ARG A 1 203 ? 105.844 91.529  123.086 1 45.983  ? 641 ARG A N   1 
ATOM 1541 C CA  . ARG A 1 203 ? 106.546 90.955  124.216 1 54.127  ? 641 ARG A CA  1 
ATOM 1542 C C   . ARG A 1 203 ? 108.007 91.406  124.262 1 52.027  ? 641 ARG A C   1 
ATOM 1543 O O   . ARG A 1 203 ? 108.777 90.882  125.046 1 52.045  ? 641 ARG A O   1 
ATOM 1544 C CB  . ARG A 1 203 ? 106.393 89.436  124.184 1 57.191  ? 641 ARG A CB  1 
ATOM 1545 C CG  . ARG A 1 203 ? 107.017 88.733  122.997 1 58.999  ? 641 ARG A CG  1 
ATOM 1546 C CD  . ARG A 1 203 ? 106.281 87.427  122.812 1 57.224  ? 641 ARG A CD  1 
ATOM 1547 N NE  . ARG A 1 203 ? 107.073 86.365  122.19  1 66.948  ? 641 ARG A NE  1 
ATOM 1548 C CZ  . ARG A 1 203 ? 107.926 85.555  122.815 1 70.573  ? 641 ARG A CZ  1 
ATOM 1549 N NH1 . ARG A 1 203 ? 108.2   85.707  124.094 1 73.407  ? 641 ARG A NH1 1 
ATOM 1550 N NH2 . ARG A 1 203 ? 108.521 84.589  122.146 1 71.247  ? 641 ARG A NH2 1 
ATOM 1551 N N   . ASN A 1 204 ? 108.383 92.402  123.46  1 45.457  ? 642 ASN A N   1 
ATOM 1552 C CA  . ASN A 1 204 ? 109.698 92.996  123.579 1 44.685  ? 642 ASN A CA  1 
ATOM 1553 C C   . ASN A 1 204 ? 109.622 94.199  124.504 1 44.256  ? 642 ASN A C   1 
ATOM 1554 O O   . ASN A 1 204 ? 108.778 95.065  124.321 1 43.462  ? 642 ASN A O   1 
ATOM 1555 C CB  . ASN A 1 204 ? 110.229 93.463  122.234 1 47.855  ? 642 ASN A CB  1 
ATOM 1556 C CG  . ASN A 1 204 ? 110.499 92.317  121.295 1 50.444  ? 642 ASN A CG  1 
ATOM 1557 O OD1 . ASN A 1 204 ? 110.563 91.161  121.726 1 60.023  ? 642 ASN A OD1 1 
ATOM 1558 N ND2 . ASN A 1 204 ? 110.631 92.624  120.016 1 58.204  ? 642 ASN A ND2 1 
ATOM 1559 N N   . LEU A 1 205 ? 110.537 94.26   125.467 1 42.114  ? 643 LEU A N   1 
ATOM 1560 C CA  . LEU A 1 205 ? 110.652 95.413  126.334 1 42.479  ? 643 LEU A CA  1 
ATOM 1561 C C   . LEU A 1 205 ? 112.009 96.067  126.104 1 41.345  ? 643 LEU A C   1 
ATOM 1562 O O   . LEU A 1 205 ? 113.04  95.421  126.267 1 42.536  ? 643 LEU A O   1 
ATOM 1563 C CB  . LEU A 1 205 ? 110.478 94.967  127.781 1 44.805  ? 643 LEU A CB  1 
ATOM 1564 C CG  . LEU A 1 205 ? 110.722 96.049  128.829 1 46.305  ? 643 LEU A CG  1 
ATOM 1565 C CD1 . LEU A 1 205 ? 109.846 97.257  128.576 1 46.583  ? 643 LEU A CD1 1 
ATOM 1566 C CD2 . LEU A 1 205 ? 110.487 95.473  130.205 1 47.436  ? 643 LEU A CD2 1 
ATOM 1567 N N   . TYR A 1 206 ? 111.986 97.338  125.728 1 37.642  ? 644 TYR A N   1 
ATOM 1568 C CA  . TYR A 1 206 ? 113.192 98.106  125.491 1 40.537  ? 644 TYR A CA  1 
ATOM 1569 C C   . TYR A 1 206 ? 113.407 99.015  126.688 1 43.982  ? 644 TYR A C   1 
ATOM 1570 O O   . TYR A 1 206 ? 112.502 99.757  127.052 1 47.45   ? 644 TYR A O   1 
ATOM 1571 C CB  . TYR A 1 206 ? 113.076 98.941  124.213 1 41.241  ? 644 TYR A CB  1 
ATOM 1572 C CG  . TYR A 1 206 ? 112.895 98.093  122.965 1 44.935  ? 644 TYR A CG  1 
ATOM 1573 C CD1 . TYR A 1 206 ? 111.636 97.606  122.624 1 45.775  ? 644 TYR A CD1 1 
ATOM 1574 C CD2 . TYR A 1 206 ? 113.98  97.732  122.171 1 42.583  ? 644 TYR A CD2 1 
ATOM 1575 C CE1 . TYR A 1 206 ? 111.466 96.791  121.515 1 45.934  ? 644 TYR A CE1 1 
ATOM 1576 C CE2 . TYR A 1 206 ? 113.819 96.915  121.07  1 42.555  ? 644 TYR A CE2 1 
ATOM 1577 C CZ  . TYR A 1 206 ? 112.559 96.445  120.743 1 42.681  ? 644 TYR A CZ  1 
ATOM 1578 O OH  . TYR A 1 206 ? 112.382 95.643  119.66  1 40.982  ? 644 TYR A OH  1 
ATOM 1579 N N   . ILE A 1 207 ? 114.585 98.917  127.312 1 43.973  ? 645 ILE A N   1 
ATOM 1580 C CA  . ILE A 1 207 ? 114.872 99.677  128.513 1 46.055  ? 645 ILE A CA  1 
ATOM 1581 C C   . ILE A 1 207 ? 116.067 100.569 128.215 1 44.474  ? 645 ILE A C   1 
ATOM 1582 O O   . ILE A 1 207 ? 117.091 100.077 127.751 1 50.523  ? 645 ILE A O   1 
ATOM 1583 C CB  . ILE A 1 207 ? 115.142 98.753  129.709 1 46.219  ? 645 ILE A CB  1 
ATOM 1584 C CG1 . ILE A 1 207 ? 114     97.779  129.922 1 47.418  ? 645 ILE A CG1 1 
ATOM 1585 C CG2 . ILE A 1 207 ? 115.415 99.594  130.958 1 48.87   ? 645 ILE A CG2 1 
ATOM 1586 C CD1 . ILE A 1 207 ? 114.405 96.501  130.623 1 47.349  ? 645 ILE A CD1 1 
ATOM 1587 N N   . ARG A 1 208 ? 115.905 101.863 128.467 1 43.488  ? 646 ARG A N   1 
ATOM 1588 C CA  . ARG A 1 208 ? 116.949 102.836 128.222 1 47.908  ? 646 ARG A CA  1 
ATOM 1589 C C   . ARG A 1 208 ? 117.546 103.278 129.558 1 48.01   ? 646 ARG A C   1 
ATOM 1590 O O   . ARG A 1 208 ? 117     104.14  130.236 1 49.871  ? 646 ARG A O   1 
ATOM 1591 C CB  . ARG A 1 208 ? 116.349 103.992 127.422 1 47.747  ? 646 ARG A CB  1 
ATOM 1592 C CG  . ARG A 1 208 ? 117.343 104.963 126.805 1 50.327  ? 646 ARG A CG  1 
ATOM 1593 C CD  . ARG A 1 208 ? 116.614 105.966 125.934 1 49.527  ? 646 ARG A CD  1 
ATOM 1594 N NE  . ARG A 1 208 ? 117.52  106.753 125.096 1 49.58   ? 646 ARG A NE  1 
ATOM 1595 C CZ  . ARG A 1 208 ? 117.868 108.008 125.306 1 48.087  ? 646 ARG A CZ  1 
ATOM 1596 N NH1 . ARG A 1 208 ? 117.443 108.651 126.376 1 49.975  ? 646 ARG A NH1 1 
ATOM 1597 N NH2 . ARG A 1 208 ? 118.691 108.609 124.472 1 52.121  ? 646 ARG A NH2 1 
ATOM 1598 N N   . PHE A 1 209 ? 118.691 102.692 129.914 1 50.123  ? 647 PHE A N   1 
ATOM 1599 C CA  . PHE A 1 209 ? 119.439 103.11  131.087 1 46.107  ? 647 PHE A CA  1 
ATOM 1600 C C   . PHE A 1 209 ? 120.207 104.377 130.742 1 46.464  ? 647 PHE A C   1 
ATOM 1601 O O   . PHE A 1 209 ? 120.862 104.44  129.702 1 51.013  ? 647 PHE A O   1 
ATOM 1602 C CB  . PHE A 1 209 ? 120.416 102.017 131.515 1 46.977  ? 647 PHE A CB  1 
ATOM 1603 C CG  . PHE A 1 209 ? 119.74  100.722 131.912 1 48.078  ? 647 PHE A CG  1 
ATOM 1604 C CD1 . PHE A 1 209 ? 119.277 99.835  130.947 1 49.896  ? 647 PHE A CD1 1 
ATOM 1605 C CD2 . PHE A 1 209 ? 119.571 100.395 133.251 1 49.027  ? 647 PHE A CD2 1 
ATOM 1606 C CE1 . PHE A 1 209 ? 118.664 98.651  131.32  1 49.235  ? 647 PHE A CE1 1 
ATOM 1607 C CE2 . PHE A 1 209 ? 118.964 99.207  133.612 1 50.331  ? 647 PHE A CE2 1 
ATOM 1608 C CZ  . PHE A 1 209 ? 118.515 98.34   132.65  1 49.5    ? 647 PHE A CZ  1 
ATOM 1609 N N   . GLN A 1 210 ? 120.132 105.373 131.627 1 43.685  ? 648 GLN A N   1 
ATOM 1610 C CA  . GLN A 1 210 ? 120.879 106.602 131.449 1 49.916  ? 648 GLN A CA  1 
ATOM 1611 C C   . GLN A 1 210 ? 121.686 106.911 132.704 1 48.208  ? 648 GLN A C   1 
ATOM 1612 O O   . GLN A 1 210 ? 121.218 106.674 133.805 1 52.971  ? 648 GLN A O   1 
ATOM 1613 C CB  . GLN A 1 210 ? 119.947 107.768 131.143 1 48.013  ? 648 GLN A CB  1 
ATOM 1614 C CG  . GLN A 1 210 ? 120.698 109.071 130.898 1 51.926  ? 648 GLN A CG  1 
ATOM 1615 C CD  . GLN A 1 210 ? 119.861 110.085 130.153 1 56.762  ? 648 GLN A CD  1 
ATOM 1616 O OE1 . GLN A 1 210 ? 118.627 110.053 130.213 1 61.975  ? 648 GLN A OE1 1 
ATOM 1617 N NE2 . GLN A 1 210 ? 120.515 110.996 129.445 1 57.462  ? 648 GLN A NE2 1 
ATOM 1618 N N   . SER A 1 211 ? 122.888 107.465 132.531 1 51.573  ? 649 SER A N   1 
ATOM 1619 C CA  . SER A 1 211 ? 123.729 107.805 133.667 1 51.906  ? 649 SER A CA  1 
ATOM 1620 C C   . SER A 1 211 ? 124.895 108.681 133.227 1 50.705  ? 649 SER A C   1 
ATOM 1621 O O   . SER A 1 211 ? 125.388 108.551 132.116 1 54.553  ? 649 SER A O   1 
ATOM 1622 C CB  . SER A 1 211 ? 124.227 106.558 134.351 1 53.178  ? 649 SER A CB  1 
ATOM 1623 O OG  . SER A 1 211 ? 125.291 106.865 135.238 1 54.765  ? 649 SER A OG  1 
ATOM 1624 N N   . ARG A 1 212 ? 125.36  109.536 134.138 1 54.938  ? 650 ARG A N   1 
ATOM 1625 C CA  . ARG A 1 212 ? 126.639 110.21  133.993 1 53.971  ? 650 ARG A CA  1 
ATOM 1626 C C   . ARG A 1 212 ? 127.768 109.201 134.149 1 51.508  ? 650 ARG A C   1 
ATOM 1627 O O   . ARG A 1 212 ? 127.596 108.148 134.759 1 54.041  ? 650 ARG A O   1 
ATOM 1628 C CB  . ARG A 1 212 ? 126.758 111.307 135.049 1 60.033  ? 650 ARG A CB  1 
ATOM 1629 C CG  . ARG A 1 212 ? 126.081 112.603 134.638 1 67.035  ? 650 ARG A CG  1 
ATOM 1630 C CD  . ARG A 1 212 ? 125.395 113.265 135.804 1 76.331  ? 650 ARG A CD  1 
ATOM 1631 N NE  . ARG A 1 212 ? 125.294 114.714 135.632 1 87.52   ? 650 ARG A NE  1 
ATOM 1632 C CZ  . ARG A 1 212 ? 126.251 115.583 135.938 1 97.267  ? 650 ARG A CZ  1 
ATOM 1633 N NH1 . ARG A 1 212 ? 127.421 115.167 136.404 1 101.13  ? 650 ARG A NH1 1 
ATOM 1634 N NH2 . ARG A 1 212 ? 126.021 116.875 135.785 1 96.767  ? 650 ARG A NH2 1 
ATOM 1635 N N   . SER A 1 213 ? 128.941 109.553 133.615 1 54.723  ? 651 SER A N   1 
ATOM 1636 C CA  . SER A 1 213 ? 130.044 108.608 133.552 1 58.843  ? 651 SER A CA  1 
ATOM 1637 C C   . SER A 1 213 ? 131.378 109.294 133.808 1 56.98   ? 651 SER A C   1 
ATOM 1638 O O   . SER A 1 213 ? 132.395 108.872 133.27  1 66.217  ? 651 SER A O   1 
ATOM 1639 C CB  . SER A 1 213 ? 130.048 107.897 132.229 1 58.76   ? 651 SER A CB  1 
ATOM 1640 O OG  . SER A 1 213 ? 130.118 108.833 131.161 1 57.381  ? 651 SER A OG  1 
ATOM 1641 N N   . GLY A 1 214 ? 131.388 110.306 134.676 1 56.233  ? 652 GLY A N   1 
ATOM 1642 C CA  . GLY A 1 214 ? 132.611 111.035 134.942 1 57.743  ? 652 GLY A CA  1 
ATOM 1643 C C   . GLY A 1 214 ? 133.026 111.801 133.69  1 58.778  ? 652 GLY A C   1 
ATOM 1644 O O   . GLY A 1 214 ? 132.224 112.529 133.11  1 59.142  ? 652 GLY A O   1 
ATOM 1645 N N   . ASP A 1 215 ? 134.283 111.617 133.278 1 57.565  ? 653 ASP A N   1 
ATOM 1646 C CA  . ASP A 1 215 ? 134.823 112.303 132.119 1 55.244  ? 653 ASP A CA  1 
ATOM 1647 C C   . ASP A 1 215 ? 134.926 111.363 130.928 1 53.672  ? 653 ASP A C   1 
ATOM 1648 O O   . ASP A 1 215 ? 135.313 111.799 129.854 1 56.891  ? 653 ASP A O   1 
ATOM 1649 C CB  . ASP A 1 215 ? 136.172 112.913 132.442 1 57.551  ? 653 ASP A CB  1 
ATOM 1650 C CG  . ASP A 1 215 ? 136.057 114.223 133.192 1 56.661  ? 653 ASP A CG  1 
ATOM 1651 O OD1 . ASP A 1 215 ? 135.655 115.181 132.544 1 61.334  ? 653 ASP A OD1 1 
ATOM 1652 O OD2 . ASP A 1 215 ? 136.355 114.256 134.404 1 65.061  ? 653 ASP A OD2 1 
ATOM 1653 N N   . ALA A 1 216 ? 134.638 110.073 131.125 1 52.008  ? 654 ALA A N   1 
ATOM 1654 C CA  . ALA A 1 216 ? 134.67  109.129 130.025 1 55.538  ? 654 ALA A CA  1 
ATOM 1655 C C   . ALA A 1 216 ? 133.425 109.332 129.175 1 60.829  ? 654 ALA A C   1 
ATOM 1656 O O   . ALA A 1 216 ? 132.442 109.925 129.618 1 60.909  ? 654 ALA A O   1 
ATOM 1657 C CB  . ALA A 1 216 ? 134.758 107.716 130.528 1 53.964  ? 654 ALA A CB  1 
ATOM 1658 N N   . MET A 1 217 ? 133.478 108.843 127.938 1 62.17   ? 655 MET A N   1 
ATOM 1659 C CA  . MET A 1 217 ? 132.331 108.95  127.058 1 63.836  ? 655 MET A CA  1 
ATOM 1660 C C   . MET A 1 217 ? 131.207 108.087 127.622 1 62.149  ? 655 MET A C   1 
ATOM 1661 O O   . MET A 1 217 ? 130.051 108.49  127.588 1 57.594  ? 655 MET A O   1 
ATOM 1662 C CB  . MET A 1 217 ? 132.703 108.552 125.629 1 64.445  ? 655 MET A CB  1 
ATOM 1663 C CG  . MET A 1 217 ? 131.672 108.969 124.603 1 66.858  ? 655 MET A CG  1 
ATOM 1664 S SD  . MET A 1 217 ? 130.531 107.626 124.227 1 77.516  ? 655 MET A SD  1 
ATOM 1665 C CE  . MET A 1 217 ? 131.676 106.44  123.502 1 82.944  ? 655 MET A CE  1 
ATOM 1666 N N   . GLY A 1 218 ? 131.556 106.905 128.144 1 62.816  ? 656 GLY A N   1 
ATOM 1667 C CA  . GLY A 1 218 ? 130.683 106.207 129.074 1 64.996  ? 656 GLY A CA  1 
ATOM 1668 C C   . GLY A 1 218 ? 130.096 104.912 128.531 1 69.249  ? 656 GLY A C   1 
ATOM 1669 O O   . GLY A 1 218 ? 129.428 104.204 129.277 1 68.298  ? 656 GLY A O   1 
ATOM 1670 N N   . MET A 1 219 ? 130.348 104.585 127.261 1 73.145  ? 657 MET A N   1 
ATOM 1671 C CA  . MET A 1 219 ? 129.71  103.427 126.66  1 75.711  ? 657 MET A CA  1 
ATOM 1672 C C   . MET A 1 219 ? 130.072 102.15  127.419 1 72.425  ? 657 MET A C   1 
ATOM 1673 O O   . MET A 1 219 ? 129.191 101.349 127.736 1 72.81   ? 657 MET A O   1 
ATOM 1674 C CB  . MET A 1 219 ? 130.076 103.299 125.179 1 84.201  ? 657 MET A CB  1 
ATOM 1675 C CG  . MET A 1 219 ? 129.199 104.132 124.272 1 94.182  ? 657 MET A CG  1 
ATOM 1676 S SD  . MET A 1 219 ? 127.628 103.355 123.851 1 102.663 ? 657 MET A SD  1 
ATOM 1677 C CE  . MET A 1 219 ? 126.664 103.57  125.355 1 105.782 ? 657 MET A CE  1 
ATOM 1678 N N   . ASN A 1 220 ? 131.364 101.956 127.703 1 70.124  ? 658 ASN A N   1 
ATOM 1679 C CA  . ASN A 1 220 ? 131.816 100.733 128.346 1 75.706  ? 658 ASN A CA  1 
ATOM 1680 C C   . ASN A 1 220 ? 131.204 100.626 129.74  1 71.486  ? 658 ASN A C   1 
ATOM 1681 O O   . ASN A 1 220 ? 130.686 99.582  130.132 1 72.166  ? 658 ASN A O   1 
ATOM 1682 C CB  . ASN A 1 220 ? 133.339 100.645 128.39  1 83.617  ? 658 ASN A CB  1 
ATOM 1683 C CG  . ASN A 1 220 ? 133.92  100.293 127.04  1 94.852  ? 658 ASN A CG  1 
ATOM 1684 O OD1 . ASN A 1 220 ? 134.712 101.063 126.485 1 98.309  ? 658 ASN A OD1 1 
ATOM 1685 N ND2 . ASN A 1 220 ? 133.546 99.141  126.5   1 99.235  ? 658 ASN A ND2 1 
ATOM 1686 N N   . MET A 1 221 ? 131.266 101.726 130.483 1 65.086  ? 659 MET A N   1 
ATOM 1687 C CA  . MET A 1 221 ? 130.8   101.746 131.855 1 67.325  ? 659 MET A CA  1 
ATOM 1688 C C   . MET A 1 221 ? 129.285 101.548 131.914 1 63.805  ? 659 MET A C   1 
ATOM 1689 O O   . MET A 1 221 ? 128.79  100.769 132.726 1 58.425  ? 659 MET A O   1 
ATOM 1690 C CB  . MET A 1 221 ? 131.186 103.074 132.504 1 68.642  ? 659 MET A CB  1 
ATOM 1691 C CG  . MET A 1 221 ? 130.809 103.149 133.953 1 74.507  ? 659 MET A CG  1 
ATOM 1692 S SD  . MET A 1 221 ? 129.25  104.006 134.247 1 86.981  ? 659 MET A SD  1 
ATOM 1693 C CE  . MET A 1 221 ? 129.966 105.424 135.078 1 86.587  ? 659 MET A CE  1 
ATOM 1694 N N   . ILE A 1 222 ? 128.556 102.234 131.028 1 62.532  ? 660 ILE A N   1 
ATOM 1695 C CA  . ILE A 1 222 ? 127.11  102.115 130.999 1 62.153  ? 660 ILE A CA  1 
ATOM 1696 C C   . ILE A 1 222 ? 126.733 100.681 130.637 1 61.024  ? 660 ILE A C   1 
ATOM 1697 O O   . ILE A 1 222 ? 125.795 100.138 131.21  1 59.928  ? 660 ILE A O   1 
ATOM 1698 C CB  . ILE A 1 222 ? 126.48  103.128 130.031 1 70.69   ? 660 ILE A CB  1 
ATOM 1699 C CG1 . ILE A 1 222 ? 126.826 104.567 130.397 1 76.515  ? 660 ILE A CG1 1 
ATOM 1700 C CG2 . ILE A 1 222 ? 124.969 102.927 129.964 1 70.489  ? 660 ILE A CG2 1 
ATOM 1701 C CD1 . ILE A 1 222 ? 125.868 105.209 131.372 1 80.856  ? 660 ILE A CD1 1 
ATOM 1702 N N   . SER A 1 223 ? 127.46  100.066 129.697 1 61.299  ? 661 SER A N   1 
ATOM 1703 C CA  . SER A 1 223 ? 127.168 98.702  129.286 1 63.453  ? 661 SER A CA  1 
ATOM 1704 C C   . SER A 1 223 ? 127.367 97.74   130.455 1 64.328  ? 661 SER A C   1 
ATOM 1705 O O   . SER A 1 223 ? 126.569 96.829  130.66  1 65.616  ? 661 SER A O   1 
ATOM 1706 C CB  . SER A 1 223 ? 127.992 98.297  128.087 1 63.07   ? 661 SER A CB  1 
ATOM 1707 O OG  . SER A 1 223 ? 127.562 98.994  126.922 1 68.606  ? 661 SER A OG  1 
ATOM 1708 N N   . LYS A 1 224 ? 128.442 97.939  131.217 1 65.638  ? 662 LYS A N   1 
ATOM 1709 C CA  . LYS A 1 224 ? 128.741 97.072  132.345 1 68.353  ? 662 LYS A CA  1 
ATOM 1710 C C   . LYS A 1 224 ? 127.621 97.17   133.383 1 64.836  ? 662 LYS A C   1 
ATOM 1711 O O   . LYS A 1 224 ? 127.096 96.16   133.85  1 64.16   ? 662 LYS A O   1 
ATOM 1712 C CB  . LYS A 1 224 ? 130.093 97.464  132.951 1 77.084  ? 662 LYS A CB  1 
ATOM 1713 C CG  . LYS A 1 224 ? 130.996 96.282  133.254 1 88.737  ? 662 LYS A CG  1 
ATOM 1714 C CD  . LYS A 1 224 ? 131.575 95.655  131.989 1 98.555  ? 662 LYS A CD  1 
ATOM 1715 C CE  . LYS A 1 224 ? 132.345 94.395  132.248 1 105.7   ? 662 LYS A CE  1 
ATOM 1716 N NZ  . LYS A 1 224 ? 133.465 94.594  133.174 1 108.279 ? 662 LYS A NZ  1 
ATOM 1717 N N   . GLY A 1 225 ? 127.25  98.408  133.725 1 60.784  ? 663 GLY A N   1 
ATOM 1718 C CA  . GLY A 1 225 ? 126.152 98.664  134.643 1 60.983  ? 663 GLY A CA  1 
ATOM 1719 C C   . GLY A 1 225 ? 124.844 98.031  134.165 1 60.07   ? 663 GLY A C   1 
ATOM 1720 O O   . GLY A 1 225 ? 124.116 97.422  134.945 1 55.353  ? 663 GLY A O   1 
ATOM 1721 N N   . THR A 1 226 ? 124.558 98.168  132.868 1 58.913  ? 664 THR A N   1 
ATOM 1722 C CA  . THR A 1 226 ? 123.329 97.63   132.309 1 57.809  ? 664 THR A CA  1 
ATOM 1723 C C   . THR A 1 226 ? 123.311 96.124  132.521 1 57.41   ? 664 THR A C   1 
ATOM 1724 O O   . THR A 1 226 ? 122.304 95.588  132.974 1 58.586  ? 664 THR A O   1 
ATOM 1725 C CB  . THR A 1 226 ? 123.187 98.016  130.836 1 57.188  ? 664 THR A CB  1 
ATOM 1726 O OG1 . THR A 1 226 ? 122.957 99.421  130.834 1 55.789  ? 664 THR A OG1 1 
ATOM 1727 C CG2 . THR A 1 226 ? 122.025 97.312  130.16  1 60.367  ? 664 THR A CG2 1 
ATOM 1728 N N   . GLU A 1 227 ? 124.438 95.461  132.239 1 61.762  ? 665 GLU A N   1 
ATOM 1729 C CA  . GLU A 1 227 ? 124.521 94.013  132.338 1 65.969  ? 665 GLU A CA  1 
ATOM 1730 C C   . GLU A 1 227 ? 124.157 93.584  133.752 1 61.101  ? 665 GLU A C   1 
ATOM 1731 O O   . GLU A 1 227 ? 123.367 92.671  133.968 1 61.374  ? 665 GLU A O   1 
ATOM 1732 C CB  . GLU A 1 227 ? 125.934 93.491  132.091 1 74.321  ? 665 GLU A CB  1 
ATOM 1733 C CG  . GLU A 1 227 ? 125.948 92.102  131.469 1 88.923  ? 665 GLU A CG  1 
ATOM 1734 C CD  . GLU A 1 227 ? 125.822 92.147  129.954 1 99.457  ? 665 GLU A CD  1 
ATOM 1735 O OE1 . GLU A 1 227 ? 125.651 91.069  129.359 1 102.394 ? 665 GLU A OE1 1 
ATOM 1736 O OE2 . GLU A 1 227 ? 125.917 93.251  129.374 1 99.566  ? 665 GLU A OE2 1 
ATOM 1737 N N   . LYS A 1 228 ? 124.787 94.241  134.716 1 60.511  ? 666 LYS A N   1 
ATOM 1738 C CA  . LYS A 1 228 ? 124.567 93.908  136.108 1 61.769  ? 666 LYS A CA  1 
ATOM 1739 C C   . LYS A 1 228 ? 123.1   94.124  136.476 1 59.182  ? 666 LYS A C   1 
ATOM 1740 O O   . LYS A 1 228 ? 122.492 93.282  137.126 1 58.347  ? 666 LYS A O   1 
ATOM 1741 C CB  . LYS A 1 228 ? 125.478 94.78   136.966 1 68.216  ? 666 LYS A CB  1 
ATOM 1742 C CG  . LYS A 1 228 ? 125.323 94.572  138.46  1 74.316  ? 666 LYS A CG  1 
ATOM 1743 C CD  . LYS A 1 228 ? 125.703 93.17   138.919 1 82.518  ? 666 LYS A CD  1 
ATOM 1744 C CE  . LYS A 1 228 ? 127.046 92.74   138.409 1 93.042  ? 666 LYS A CE  1 
ATOM 1745 N NZ  . LYS A 1 228 ? 127.564 91.576  139.135 1 97.056  ? 666 LYS A NZ  1 
ATOM 1746 N N   . ALA A 1 229 ? 122.532 95.247  136.032 1 55.949  ? 667 ALA A N   1 
ATOM 1747 C CA  . ALA A 1 229 ? 121.136 95.561  136.301 1 55.053  ? 667 ALA A CA  1 
ATOM 1748 C C   . ALA A 1 229 ? 120.203 94.535  135.657 1 56.995  ? 667 ALA A C   1 
ATOM 1749 O O   . ALA A 1 229 ? 119.201 94.154  136.257 1 54.858  ? 667 ALA A O   1 
ATOM 1750 C CB  . ALA A 1 229 ? 120.817 96.948  135.821 1 54.699  ? 667 ALA A CB  1 
ATOM 1751 N N   . LEU A 1 230 ? 120.546 94.061  134.455 1 57.008  ? 668 LEU A N   1 
ATOM 1752 C CA  . LEU A 1 230 ? 119.711 93.082  133.782 1 56.023  ? 668 LEU A CA  1 
ATOM 1753 C C   . LEU A 1 230 ? 119.774 91.746  134.513 1 54.565  ? 668 LEU A C   1 
ATOM 1754 O O   . LEU A 1 230 ? 118.782 91.026  134.535 1 55.426  ? 668 LEU A O   1 
ATOM 1755 C CB  . LEU A 1 230 ? 120.097 92.949  132.31  1 58.57   ? 668 LEU A CB  1 
ATOM 1756 C CG  . LEU A 1 230 ? 119.686 94.115  131.406 1 62.637  ? 668 LEU A CG  1 
ATOM 1757 C CD1 . LEU A 1 230 ? 120.05  93.837  129.956 1 67.078  ? 668 LEU A CD1 1 
ATOM 1758 C CD2 . LEU A 1 230 ? 118.203 94.416  131.516 1 64.459  ? 668 LEU A CD2 1 
ATOM 1759 N N   . SER A 1 231 ? 120.929 91.393  135.09  1 58.264  ? 669 SER A N   1 
ATOM 1760 C CA  . SER A 1 231 ? 121.016 90.174  135.88  1 60.117  ? 669 SER A CA  1 
ATOM 1761 C C   . SER A 1 231 ? 120.085 90.276  137.084 1 55.523  ? 669 SER A C   1 
ATOM 1762 O O   . SER A 1 231 ? 119.347 89.345  137.41  1 60.309  ? 669 SER A O   1 
ATOM 1763 C CB  . SER A 1 231 ? 122.43  89.884  136.309 1 64.573  ? 669 SER A CB  1 
ATOM 1764 O OG  . SER A 1 231 ? 123.208 89.466  135.196 1 74.632  ? 669 SER A OG  1 
ATOM 1765 N N   . LYS A 1 232 ? 120.125 91.43   137.743 1 56.47   ? 670 LYS A N   1 
ATOM 1766 C CA  . LYS A 1 232 ? 119.284 91.644  138.902 1 57.767  ? 670 LYS A CA  1 
ATOM 1767 C C   . LYS A 1 232 ? 117.815 91.534  138.504 1 59.738  ? 670 LYS A C   1 
ATOM 1768 O O   . LYS A 1 232 ? 117.034 90.9    139.2   1 57.205  ? 670 LYS A O   1 
ATOM 1769 C CB  . LYS A 1 232 ? 119.575 93.004  139.537 1 62.994  ? 670 LYS A CB  1 
ATOM 1770 C CG  . LYS A 1 232 ? 118.643 93.374  140.672 1 65.516  ? 670 LYS A CG  1 
ATOM 1771 C CD  . LYS A 1 232 ? 118.604 92.343  141.793 1 70.22   ? 670 LYS A CD  1 
ATOM 1772 C CE  . LYS A 1 232 ? 119.834 92.398  142.654 1 73.125  ? 670 LYS A CE  1 
ATOM 1773 N NZ  . LYS A 1 232 ? 120.108 91.104  143.281 1 77.222  ? 670 LYS A NZ  1 
ATOM 1774 N N   . LEU A 1 233 ? 117.454 92.144  137.37  1 59.402  ? 671 LEU A N   1 
ATOM 1775 C CA  . LEU A 1 233 ? 116.086 92.096  136.878 1 56.459  ? 671 LEU A CA  1 
ATOM 1776 C C   . LEU A 1 233 ? 115.69  90.654  136.593 1 57.01   ? 671 LEU A C   1 
ATOM 1777 O O   . LEU A 1 233 ? 114.575 90.268  136.894 1 55.684  ? 671 LEU A O   1 
ATOM 1778 C CB  . LEU A 1 233 ? 115.938 92.962  135.63  1 57.373  ? 671 LEU A CB  1 
ATOM 1779 C CG  . LEU A 1 233 ? 114.525 93.086  135.055 1 56.812  ? 671 LEU A CG  1 
ATOM 1780 C CD1 . LEU A 1 233 ? 113.563 93.632  136.082 1 57.248  ? 671 LEU A CD1 1 
ATOM 1781 C CD2 . LEU A 1 233 ? 114.526 93.987  133.838 1 55.738  ? 671 LEU A CD2 1 
ATOM 1782 N N   . HIS A 1 234 ? 116.605 89.866  136.019 1 57.127  ? 672 HIS A N   1 
ATOM 1783 C CA  . HIS A 1 234 ? 116.333 88.467  135.744 1 60.884  ? 672 HIS A CA  1 
ATOM 1784 C C   . HIS A 1 234 ? 116.007 87.713  137.028 1 61.374  ? 672 HIS A C   1 
ATOM 1785 O O   . HIS A 1 234 ? 115.237 86.764  137.002 1 58.965  ? 672 HIS A O   1 
ATOM 1786 C CB  . HIS A 1 234 ? 117.505 87.797  135.026 1 64.402  ? 672 HIS A CB  1 
ATOM 1787 C CG  . HIS A 1 234 ? 117.171 86.443  134.511 1 70.578  ? 672 HIS A CG  1 
ATOM 1788 N ND1 . HIS A 1 234 ? 117.618 85.288  135.115 1 82.805  ? 672 HIS A ND1 1 
ATOM 1789 C CD2 . HIS A 1 234 ? 116.441 86.059  133.456 1 75.375  ? 672 HIS A CD2 1 
ATOM 1790 C CE1 . HIS A 1 234 ? 117.17  84.24   134.435 1 82.23   ? 672 HIS A CE1 1 
ATOM 1791 N NE2 . HIS A 1 234 ? 116.453 84.686  133.422 1 81.001  ? 672 HIS A NE2 1 
ATOM 1792 N N   . GLU A 1 235 ? 116.576 88.128  138.157 1 65.317  ? 673 GLU A N   1 
ATOM 1793 C CA  . GLU A 1 235 ? 116.298 87.439  139.409 1 71.937  ? 673 GLU A CA  1 
ATOM 1794 C C   . GLU A 1 235 ? 114.808 87.502  139.749 1 68.626  ? 673 GLU A C   1 
ATOM 1795 O O   . GLU A 1 235 ? 114.251 86.54   140.265 1 72.332  ? 673 GLU A O   1 
ATOM 1796 C CB  . GLU A 1 235 ? 117.126 88.006  140.559 1 77.794  ? 673 GLU A CB  1 
ATOM 1797 C CG  . GLU A 1 235 ? 118.61  87.685  140.429 1 85.189  ? 673 GLU A CG  1 
ATOM 1798 C CD  . GLU A 1 235 ? 119.456 88.197  141.578 1 92.839  ? 673 GLU A CD  1 
ATOM 1799 O OE1 . GLU A 1 235 ? 118.909 88.84   142.502 1 91.15   ? 673 GLU A OE1 1 
ATOM 1800 O OE2 . GLU A 1 235 ? 120.68  87.948  141.535 1 97.957  ? 673 GLU A OE2 1 
ATOM 1801 N N   . TYR A 1 236 ? 114.156 88.628  139.456 1 64.784  ? 674 TYR A N   1 
ATOM 1802 C CA  . TYR A 1 236 ? 112.749 88.795  139.796 1 64.765  ? 674 TYR A CA  1 
ATOM 1803 C C   . TYR A 1 236 ? 111.83  88.184  138.735 1 63.423  ? 674 TYR A C   1 
ATOM 1804 O O   . TYR A 1 236 ? 110.721 87.77   139.056 1 65.412  ? 674 TYR A O   1 
ATOM 1805 C CB  . TYR A 1 236 ? 112.409 90.273  139.982 1 62.759  ? 674 TYR A CB  1 
ATOM 1806 C CG  . TYR A 1 236 ? 112.931 90.858  141.284 1 71.209  ? 674 TYR A CG  1 
ATOM 1807 C CD1 . TYR A 1 236 ? 114.285 91.118  141.46  1 74.445  ? 674 TYR A CD1 1 
ATOM 1808 C CD2 . TYR A 1 236 ? 112.073 91.138  142.341 1 74.223  ? 674 TYR A CD2 1 
ATOM 1809 C CE1 . TYR A 1 236 ? 114.767 91.647  142.645 1 77.375  ? 674 TYR A CE1 1 
ATOM 1810 C CE2 . TYR A 1 236 ? 112.544 91.672  143.529 1 76.948  ? 674 TYR A CE2 1 
ATOM 1811 C CZ  . TYR A 1 236 ? 113.895 91.924  143.683 1 77.485  ? 674 TYR A CZ  1 
ATOM 1812 O OH  . TYR A 1 236 ? 114.353 92.444  144.856 1 85.847  ? 674 TYR A OH  1 
ATOM 1813 N N   . PHE A 1 237 ? 112.279 88.143  137.475 1 61.648  ? 675 PHE A N   1 
ATOM 1814 C CA  . PHE A 1 237 ? 111.488 87.594  136.384 1 56.068  ? 675 PHE A CA  1 
ATOM 1815 C C   . PHE A 1 237 ? 112.3   86.522  135.673 1 55.392  ? 675 PHE A C   1 
ATOM 1816 O O   . PHE A 1 237 ? 112.844 86.775  134.604 1 57.107  ? 675 PHE A O   1 
ATOM 1817 C CB  . PHE A 1 237 ? 111.077 88.691  135.399 1 53.5    ? 675 PHE A CB  1 
ATOM 1818 C CG  . PHE A 1 237 ? 110.267 89.79   136.058 1 52.484  ? 675 PHE A CG  1 
ATOM 1819 C CD1 . PHE A 1 237 ? 108.895 89.656  136.241 1 55.292  ? 675 PHE A CD1 1 
ATOM 1820 C CD2 . PHE A 1 237 ? 110.891 90.927  136.542 1 51.882  ? 675 PHE A CD2 1 
ATOM 1821 C CE1 . PHE A 1 237 ? 108.173 90.652  136.878 1 53.811  ? 675 PHE A CE1 1 
ATOM 1822 C CE2 . PHE A 1 237 ? 110.163 91.921  137.174 1 53.619  ? 675 PHE A CE2 1 
ATOM 1823 C CZ  . PHE A 1 237 ? 108.807 91.778  137.347 1 55.908  ? 675 PHE A CZ  1 
ATOM 1824 N N   . PRO A 1 238 ? 112.398 85.293  136.227 1 60.331  ? 676 PRO A N   1 
ATOM 1825 C CA  . PRO A 1 238 ? 113.238 84.261  135.631 1 62.103  ? 676 PRO A CA  1 
ATOM 1826 C C   . PRO A 1 238 ? 112.879 83.899  134.191 1 62.587  ? 676 PRO A C   1 
ATOM 1827 O O   . PRO A 1 238 ? 113.695 83.315  133.484 1 66.785  ? 676 PRO A O   1 
ATOM 1828 C CB  . PRO A 1 238 ? 113.079 83.063  136.566 1 61.676  ? 676 PRO A CB  1 
ATOM 1829 C CG  . PRO A 1 238 ? 111.817 83.354  137.345 1 62.589  ? 676 PRO A CG  1 
ATOM 1830 C CD  . PRO A 1 238 ? 111.719 84.843  137.452 1 60.984  ? 676 PRO A CD  1 
ATOM 1831 N N   . GLU A 1 239 ? 111.664 84.237  133.755 1 62.853  ? 677 GLU A N   1 
ATOM 1832 C CA  . GLU A 1 239 ? 111.243 83.927  132.399 1 65.53   ? 677 GLU A CA  1 
ATOM 1833 C C   . GLU A 1 239 ? 111.798 84.934  131.392 1 62.254  ? 677 GLU A C   1 
ATOM 1834 O O   . GLU A 1 239 ? 111.753 84.684  130.192 1 63.617  ? 677 GLU A O   1 
ATOM 1835 C CB  . GLU A 1 239 ? 109.72  83.88   132.333 1 73.193  ? 677 GLU A CB  1 
ATOM 1836 C CG  . GLU A 1 239 ? 109.127 82.694  133.082 1 80.914  ? 677 GLU A CG  1 
ATOM 1837 C CD  . GLU A 1 239 ? 109.258 81.398  132.305 1 95.867  ? 677 GLU A CD  1 
ATOM 1838 O OE1 . GLU A 1 239 ? 110.352 80.792  132.325 1 100.239 ? 677 GLU A OE1 1 
ATOM 1839 O OE2 . GLU A 1 239 ? 108.264 81.022  131.642 1 104.019 ? 677 GLU A OE2 1 
ATOM 1840 N N   . MET A 1 240 ? 112.328 86.062  131.87  1 57.634  ? 678 MET A N   1 
ATOM 1841 C CA  . MET A 1 240 ? 112.886 87.065  130.982 1 58.829  ? 678 MET A CA  1 
ATOM 1842 C C   . MET A 1 240 ? 114.084 86.504  130.216 1 61.032  ? 678 MET A C   1 
ATOM 1843 O O   . MET A 1 240 ? 114.905 85.776  130.766 1 63.404  ? 678 MET A O   1 
ATOM 1844 C CB  . MET A 1 240 ? 113.324 88.3    131.765 1 61.931  ? 678 MET A CB  1 
ATOM 1845 C CG  . MET A 1 240 ? 113.67  89.458  130.876 1 67.253  ? 678 MET A CG  1 
ATOM 1846 S SD  . MET A 1 240 ? 113.787 90.995  131.802 1 78.665  ? 678 MET A SD  1 
ATOM 1847 C CE  . MET A 1 240 ? 115.392 90.775  132.575 1 75.414  ? 678 MET A CE  1 
ATOM 1848 N N   . GLN A 1 241 ? 114.131 86.824  128.92  1 61.872  ? 679 GLN A N   1 
ATOM 1849 C CA  . GLN A 1 241 ? 115.246 86.489  128.054 1 63.497  ? 679 GLN A CA  1 
ATOM 1850 C C   . GLN A 1 241 ? 115.913 87.791  127.623 1 57.173  ? 679 GLN A C   1 
ATOM 1851 O O   . GLN A 1 241 ? 115.268 88.668  127.06  1 59.383  ? 679 GLN A O   1 
ATOM 1852 C CB  . GLN A 1 241 ? 114.74  85.693  126.852 1 68.972  ? 679 GLN A CB  1 
ATOM 1853 C CG  . GLN A 1 241 ? 115.794 85.435  125.785 1 85.137  ? 679 GLN A CG  1 
ATOM 1854 C CD  . GLN A 1 241 ? 115.224 84.794  124.539 1 99.733  ? 679 GLN A CD  1 
ATOM 1855 O OE1 . GLN A 1 241 ? 114.046 84.419  124.485 1 105.416 ? 679 GLN A OE1 1 
ATOM 1856 N NE2 . GLN A 1 241 ? 116.064 84.659  123.523 1 103.424 ? 679 GLN A NE2 1 
ATOM 1857 N N   . ILE A 1 242 ? 117.2   87.943  127.921 1 58.725  ? 680 ILE A N   1 
ATOM 1858 C CA  . ILE A 1 242 ? 117.922 89.113  127.455 1 59.308  ? 680 ILE A CA  1 
ATOM 1859 C C   . ILE A 1 242 ? 118.297 88.877  125.996 1 60.973  ? 680 ILE A C   1 
ATOM 1860 O O   . ILE A 1 242 ? 119.164 88.065  125.693 1 65.84   ? 680 ILE A O   1 
ATOM 1861 C CB  . ILE A 1 242 ? 119.157 89.408  128.319 1 63.58   ? 680 ILE A CB  1 
ATOM 1862 C CG1 . ILE A 1 242 ? 118.759 89.801  129.739 1 65.926  ? 680 ILE A CG1 1 
ATOM 1863 C CG2 . ILE A 1 242 ? 120.002 90.488  127.646 1 62.491  ? 680 ILE A CG2 1 
ATOM 1864 C CD1 . ILE A 1 242 ? 119.676 89.24   130.808 1 73.697  ? 680 ILE A CD1 1 
ATOM 1865 N N   . LEU A 1 243 ? 117.631 89.601  125.097 1 57.258  ? 681 LEU A N   1 
ATOM 1866 C CA  . LEU A 1 243 ? 117.768 89.358  123.672 1 59.835  ? 681 LEU A CA  1 
ATOM 1867 C C   . LEU A 1 243 ? 119.021 90.054  123.147 1 55.308  ? 681 LEU A C   1 
ATOM 1868 O O   . LEU A 1 243 ? 119.814 89.435  122.447 1 58.34   ? 681 LEU A O   1 
ATOM 1869 C CB  . LEU A 1 243 ? 116.496 89.826  122.969 1 61.6    ? 681 LEU A CB  1 
ATOM 1870 C CG  . LEU A 1 243 ? 116.277 89.368  121.523 1 68.72   ? 681 LEU A CG  1 
ATOM 1871 C CD1 . LEU A 1 243 ? 117.113 90.173  120.563 1 75.422  ? 681 LEU A CD1 1 
ATOM 1872 C CD2 . LEU A 1 243 ? 116.543 87.883  121.311 1 69.393  ? 681 LEU A CD2 1 
ATOM 1873 N N   . ALA A 1 244 ? 119.211 91.328  123.494 1 53.016  ? 682 ALA A N   1 
ATOM 1874 C CA  . ALA A 1 244 ? 120.423 92.027  123.105 1 53.424  ? 682 ALA A CA  1 
ATOM 1875 C C   . ALA A 1 244 ? 120.692 93.177  124.065 1 54.264  ? 682 ALA A C   1 
ATOM 1876 O O   . ALA A 1 244 ? 119.788 93.947  124.368 1 53.534  ? 682 ALA A O   1 
ATOM 1877 C CB  . ALA A 1 244 ? 120.288 92.537  121.687 1 57.108  ? 682 ALA A CB  1 
ATOM 1878 N N   . VAL A 1 245 ? 121.947 93.309  124.499 1 53.883  ? 683 VAL A N   1 
ATOM 1879 C CA  . VAL A 1 245 ? 122.34  94.375  125.407 1 56.389  ? 683 VAL A CA  1 
ATOM 1880 C C   . VAL A 1 245 ? 122.205 95.73   124.718 1 54.034  ? 683 VAL A C   1 
ATOM 1881 O O   . VAL A 1 245 ? 122.048 96.754  125.386 1 55.499  ? 683 VAL A O   1 
ATOM 1882 C CB  . VAL A 1 245 ? 123.77  94.155  125.929 1 61.382  ? 683 VAL A CB  1 
ATOM 1883 C CG1 . VAL A 1 245 ? 123.873 92.862  126.734 1 63.031  ? 683 VAL A CG1 1 
ATOM 1884 C CG2 . VAL A 1 245 ? 124.794 94.177  124.8   1 63.905  ? 683 VAL A CG2 1 
ATOM 1885 N N   . SER A 1 246 ? 122.263 95.728  123.381 1 57.012  ? 684 SER A N   1 
ATOM 1886 C CA  . SER A 1 246 ? 121.962 96.918  122.602 1 60.3    ? 684 SER A CA  1 
ATOM 1887 C C   . SER A 1 246 ? 120.802 96.613  121.66  1 57.16   ? 684 SER A C   1 
ATOM 1888 O O   . SER A 1 246 ? 120.969 95.819  120.737 1 56.872  ? 684 SER A O   1 
ATOM 1889 C CB  . SER A 1 246 ? 123.172 97.38   121.842 1 64.7    ? 684 SER A CB  1 
ATOM 1890 O OG  . SER A 1 246 ? 122.9   98.603  121.166 1 69.682  ? 684 SER A OG  1 
ATOM 1891 N N   . GLY A 1 247 ? 119.633 97.214  121.923 1 54.215  ? 685 GLY A N   1 
ATOM 1892 C CA  . GLY A 1 247 ? 118.436 96.964  121.133 1 53.97   ? 685 GLY A CA  1 
ATOM 1893 C C   . GLY A 1 247 ? 118.094 98.137  120.216 1 51.706  ? 685 GLY A C   1 
ATOM 1894 O O   . GLY A 1 247 ? 116.93  98.318  119.879 1 52.82   ? 685 GLY A O   1 
ATOM 1895 N N   . ASN A 1 248 ? 119.11  98.927  119.843 1 45.667  ? 686 ASN A N   1 
ATOM 1896 C CA  . ASN A 1 248 ? 118.936 100.116 119.024 1 47.914  ? 686 ASN A CA  1 
ATOM 1897 C C   . ASN A 1 248 ? 118.026 101.132 119.702 1 49.295  ? 686 ASN A C   1 
ATOM 1898 O O   . ASN A 1 248 ? 117.542 102.057 119.049 1 51.611  ? 686 ASN A O   1 
ATOM 1899 C CB  . ASN A 1 248 ? 118.431 99.799  117.62  1 51.011  ? 686 ASN A CB  1 
ATOM 1900 C CG  . ASN A 1 248 ? 119.511 99.213  116.74  1 52.886  ? 686 ASN A CG  1 
ATOM 1901 O OD1 . ASN A 1 248 ? 120.623 98.942  117.209 1 53.325  ? 686 ASN A OD1 1 
ATOM 1902 N ND2 . ASN A 1 248 ? 119.198 99.015  115.466 1 49.932  ? 686 ASN A ND2 1 
ATOM 1903 N N   . TYR A 1 249 ? 117.889 101.026 121.027 1 52.827  ? 687 TYR A N   1 
ATOM 1904 C CA  . TYR A 1 249 ? 117.027 101.944 121.748 1 51.711  ? 687 TYR A CA  1 
ATOM 1905 C C   . TYR A 1 249 ? 117.843 102.992 122.508 1 55.64   ? 687 TYR A C   1 
ATOM 1906 O O   . TYR A 1 249 ? 117.265 103.776 123.259 1 58.094  ? 687 TYR A O   1 
ATOM 1907 C CB  . TYR A 1 249 ? 116.134 101.12  122.678 1 53.023  ? 687 TYR A CB  1 
ATOM 1908 C CG  . TYR A 1 249 ? 114.948 101.904 123.208 1 53.766  ? 687 TYR A CG  1 
ATOM 1909 C CD1 . TYR A 1 249 ? 114.032 102.483 122.336 1 60.415  ? 687 TYR A CD1 1 
ATOM 1910 C CD2 . TYR A 1 249 ? 114.764 102.08  124.575 1 58.501  ? 687 TYR A CD2 1 
ATOM 1911 C CE1 . TYR A 1 249 ? 112.95  103.205 122.809 1 62.555  ? 687 TYR A CE1 1 
ATOM 1912 C CE2 . TYR A 1 249 ? 113.683 102.795 125.063 1 58.758  ? 687 TYR A CE2 1 
ATOM 1913 C CZ  . TYR A 1 249 ? 112.782 103.36  124.175 1 61.816  ? 687 TYR A CZ  1 
ATOM 1914 O OH  . TYR A 1 249 ? 111.723 104.073 124.637 1 64.902  ? 687 TYR A OH  1 
ATOM 1915 N N   . CYS A 1 250 ? 119.171 103.017 122.321 1 55.79   ? 688 CYS A N   1 
ATOM 1916 C CA  . CYS A 1 250 ? 120.036 103.921 123.075 1 54.8    ? 688 CYS A CA  1 
ATOM 1917 C C   . CYS A 1 250 ? 119.78  105.386 122.706 1 56.042  ? 688 CYS A C   1 
ATOM 1918 O O   . CYS A 1 250 ? 119.446 106.181 123.581 1 56.319  ? 688 CYS A O   1 
ATOM 1919 C CB  . CYS A 1 250 ? 121.51  103.564 122.923 1 56.311  ? 688 CYS A CB  1 
ATOM 1920 S SG  . CYS A 1 250 ? 121.787 101.786 122.728 1 62.998  ? 688 CYS A SG  1 
ATOM 1921 N N   . THR A 1 251 ? 119.919 105.79  121.432 1 55.122  ? 689 THR A N   1 
ATOM 1922 C CA  . THR A 1 251 ? 120.333 104.993 120.286 1 59.196  ? 689 THR A CA  1 
ATOM 1923 C C   . THR A 1 251 ? 121.757 105.408 119.919 1 58.661  ? 689 THR A C   1 
ATOM 1924 O O   . THR A 1 251 ? 122.068 106.592 119.846 1 58.162  ? 689 THR A O   1 
ATOM 1925 C CB  . THR A 1 251 ? 119.386 105.219 119.102 1 64.287  ? 689 THR A CB  1 
ATOM 1926 O OG1 . THR A 1 251 ? 118.103 104.662 119.372 1 62.718  ? 689 THR A OG1 1 
ATOM 1927 C CG2 . THR A 1 251 ? 119.872 104.536 117.839 1 70.024  ? 689 THR A CG2 1 
ATOM 1928 N N   . ASP A 1 252 ? 122.607 104.414 119.668 1 58.068  ? 690 ASP A N   1 
ATOM 1929 C CA  . ASP A 1 252 ? 124.02  104.654 119.442 1 57.965  ? 690 ASP A CA  1 
ATOM 1930 C C   . ASP A 1 252 ? 124.342 104.618 117.944 1 53.002  ? 690 ASP A C   1 
ATOM 1931 O O   . ASP A 1 252 ? 124.15  103.593 117.291 1 56.449  ? 690 ASP A O   1 
ATOM 1932 C CB  . ASP A 1 252 ? 124.838 103.625 120.198 1 61.259  ? 690 ASP A CB  1 
ATOM 1933 C CG  . ASP A 1 252 ? 126.328 103.876 120.115 1 66.291  ? 690 ASP A CG  1 
ATOM 1934 O OD1 . ASP A 1 252 ? 126.703 105.063 120.13  1 64.168  ? 690 ASP A OD1 1 
ATOM 1935 O OD2 . ASP A 1 252 ? 127.08  102.883 120.074 1 80.327  ? 690 ASP A OD2 1 
ATOM 1936 N N   . LYS A 1 253 ? 124.836 105.745 117.417 1 52.322  ? 691 LYS A N   1 
ATOM 1937 C CA  . LYS A 1 253 ? 125.42  105.84  116.08  1 58.841  ? 691 LYS A CA  1 
ATOM 1938 C C   . LYS A 1 253 ? 124.403 105.53  114.98  1 58.004  ? 691 LYS A C   1 
ATOM 1939 O O   . LYS A 1 253 ? 124.738 104.941 113.953 1 56.071  ? 691 LYS A O   1 
ATOM 1940 C CB  . LYS A 1 253 ? 126.621 104.899 115.948 1 58.175  ? 691 LYS A CB  1 
ATOM 1941 C CG  . LYS A 1 253 ? 127.813 105.327 116.76  1 62.451  ? 691 LYS A CG  1 
ATOM 1942 C CD  . LYS A 1 253 ? 128.881 104.252 116.773 1 65.809  ? 691 LYS A CD  1 
ATOM 1943 C CE  . LYS A 1 253 ? 130.013 104.62  117.671 1 65.31   ? 691 LYS A CE  1 
ATOM 1944 N NZ  . LYS A 1 253 ? 130.908 103.475 117.876 1 71.232  ? 691 LYS A NZ  1 
ATOM 1945 N N   . LYS A 1 254 ? 123.151 105.911 115.217 1 57.429  ? 692 LYS A N   1 
ATOM 1946 C CA  . LYS A 1 254 ? 122.126 105.863 114.195 1 58.186  ? 692 LYS A CA  1 
ATOM 1947 C C   . LYS A 1 254 ? 121.264 107.104 114.358 1 56.266  ? 692 LYS A C   1 
ATOM 1948 O O   . LYS A 1 254 ? 121.129 107.62  115.467 1 65.484  ? 692 LYS A O   1 
ATOM 1949 C CB  . LYS A 1 254 ? 121.247 104.614 114.294 1 57.891  ? 692 LYS A CB  1 
ATOM 1950 C CG  . LYS A 1 254 ? 121.782 103.385 113.588 1 59.619  ? 692 LYS A CG  1 
ATOM 1951 C CD  . LYS A 1 254 ? 122.648 102.479 114.452 1 62.728  ? 692 LYS A CD  1 
ATOM 1952 C CE  . LYS A 1 254 ? 121.859 101.857 115.559 1 60.554  ? 692 LYS A CE  1 
ATOM 1953 N NZ  . LYS A 1 254 ? 122.646 100.925 116.368 1 60.271  ? 692 LYS A NZ  1 
ATOM 1954 N N   . PRO A 1 255 ? 120.67  107.628 113.265 1 55.468  ? 693 PRO A N   1 
ATOM 1955 C CA  . PRO A 1 255 ? 119.683 108.685 113.404 1 56.864  ? 693 PRO A CA  1 
ATOM 1956 C C   . PRO A 1 255 ? 118.428 108.131 114.07  1 57.884  ? 693 PRO A C   1 
ATOM 1957 O O   . PRO A 1 255 ? 117.898 107.111 113.635 1 55.056  ? 693 PRO A O   1 
ATOM 1958 C CB  . PRO A 1 255 ? 119.471 109.169 111.974 1 56.42   ? 693 PRO A CB  1 
ATOM 1959 C CG  . PRO A 1 255 ? 119.764 107.927 111.149 1 55.096  ? 693 PRO A CG  1 
ATOM 1960 C CD  . PRO A 1 255 ? 120.873 107.209 111.867 1 55.146  ? 693 PRO A CD  1 
ATOM 1961 N N   . ALA A 1 256 ? 118.01  108.766 115.164 1 56.875  ? 694 ALA A N   1 
ATOM 1962 C CA  . ALA A 1 256 ? 116.844 108.326 115.907 1 55.045  ? 694 ALA A CA  1 
ATOM 1963 C C   . ALA A 1 256 ? 116.22  109.545 116.573 1 53.165  ? 694 ALA A C   1 
ATOM 1964 O O   . ALA A 1 256 ? 116.922 110.381 117.147 1 58.109  ? 694 ALA A O   1 
ATOM 1965 C CB  . ALA A 1 256 ? 117.216 107.262 116.928 1 55.076  ? 694 ALA A CB  1 
ATOM 1966 N N   . ALA A 1 257 ? 114.889 109.597 116.528 1 48.68   ? 695 ALA A N   1 
ATOM 1967 C CA  . ALA A 1 257 ? 114.144 110.663 117.168 1 49.019  ? 695 ALA A CA  1 
ATOM 1968 C C   . ALA A 1 257 ? 114.354 110.649 118.682 1 43.183  ? 695 ALA A C   1 
ATOM 1969 O O   . ALA A 1 257 ? 114.226 111.691 119.316 1 48.89   ? 695 ALA A O   1 
ATOM 1970 C CB  . ALA A 1 257 ? 112.677 110.527 116.813 1 48.648  ? 695 ALA A CB  1 
ATOM 1971 N N   . ILE A 1 258 ? 114.627 109.474 119.259 1 43.04   ? 696 ILE A N   1 
ATOM 1972 C CA  . ILE A 1 258 ? 114.723 109.368 120.706 1 45.878  ? 696 ILE A CA  1 
ATOM 1973 C C   . ILE A 1 258 ? 115.883 110.212 121.236 1 47.063  ? 696 ILE A C   1 
ATOM 1974 O O   . ILE A 1 258 ? 115.74  110.859 122.268 1 47.199  ? 696 ILE A O   1 
ATOM 1975 C CB  . ILE A 1 258 ? 114.805 107.91  121.176 1 47.158  ? 696 ILE A CB  1 
ATOM 1976 C CG1 . ILE A 1 258 ? 114.567 107.85  122.683 1 49.413  ? 696 ILE A CG1 1 
ATOM 1977 C CG2 . ILE A 1 258 ? 116.122 107.241 120.765 1 48.034  ? 696 ILE A CG2 1 
ATOM 1978 C CD1 . ILE A 1 258 ? 114.12  106.498 123.175 1 46.59   ? 696 ILE A CD1 1 
ATOM 1979 N N   . ASN A 1 259 ? 117.025 110.215 120.54  1 46.184  ? 697 ASN A N   1 
ATOM 1980 C CA  . ASN A 1 259 ? 118.147 111.041 120.961 1 47.354  ? 697 ASN A CA  1 
ATOM 1981 C C   . ASN A 1 259 ? 117.764 112.515 120.869 1 43.131  ? 697 ASN A C   1 
ATOM 1982 O O   . ASN A 1 259 ? 118.128 113.315 121.718 1 44.732  ? 697 ASN A O   1 
ATOM 1983 C CB  . ASN A 1 259 ? 119.41  110.731 120.161 1 49.301  ? 697 ASN A CB  1 
ATOM 1984 C CG  . ASN A 1 259 ? 119.896 109.311 120.338 1 55.256  ? 697 ASN A CG  1 
ATOM 1985 O OD1 . ASN A 1 259 ? 119.526 108.627 121.299 1 51.999  ? 697 ASN A OD1 1 
ATOM 1986 N ND2 . ASN A 1 259 ? 120.684 108.826 119.387 1 59.455  ? 697 ASN A ND2 1 
ATOM 1987 N N   . TRP A 1 260 ? 117.035 112.888 119.818 1 42.479  ? 698 TRP A N   1 
ATOM 1988 C CA  . TRP A 1 260 ? 116.633 114.269 119.631 1 43.235  ? 698 TRP A CA  1 
ATOM 1989 C C   . TRP A 1 260 ? 115.688 114.732 120.74  1 45.506  ? 698 TRP A C   1 
ATOM 1990 O O   . TRP A 1 260 ? 115.781 115.857 121.214 1 43.802  ? 698 TRP A O   1 
ATOM 1991 C CB  . TRP A 1 260 ? 115.967 114.389 118.261 1 42.949  ? 698 TRP A CB  1 
ATOM 1992 C CG  . TRP A 1 260 ? 115.448 115.754 117.932 1 43.822  ? 698 TRP A CG  1 
ATOM 1993 C CD1 . TRP A 1 260 ? 114.145 116.132 117.8   1 46.308  ? 698 TRP A CD1 1 
ATOM 1994 C CD2 . TRP A 1 260 ? 116.239 116.921 117.642 1 44.689  ? 698 TRP A CD2 1 
ATOM 1995 N NE1 . TRP A 1 260 ? 114.073 117.45  117.436 1 43.538  ? 698 TRP A NE1 1 
ATOM 1996 C CE2 . TRP A 1 260 ? 115.34  117.96  117.33  1 43.197  ? 698 TRP A CE2 1 
ATOM 1997 C CE3 . TRP A 1 260 ? 117.61  117.175 117.603 1 43.979  ? 698 TRP A CE3 1 
ATOM 1998 C CZ2 . TRP A 1 260 ? 115.778 119.24  116.998 1 46.041  ? 698 TRP A CZ2 1 
ATOM 1999 C CZ3 . TRP A 1 260 ? 118.047 118.435 117.265 1 44.307  ? 698 TRP A CZ3 1 
ATOM 2000 C CH2 . TRP A 1 260 ? 117.141 119.452 116.97  1 45.543  ? 698 TRP A CH2 1 
ATOM 2001 N N   . ILE A 1 261 ? 114.766 113.86  121.145 1 44.071  ? 699 ILE A N   1 
ATOM 2002 C CA  . ILE A 1 261 ? 113.699 114.243 122.058 1 49.272  ? 699 ILE A CA  1 
ATOM 2003 C C   . ILE A 1 261 ? 114.148 114.127 123.514 1 47.661  ? 699 ILE A C   1 
ATOM 2004 O O   . ILE A 1 261 ? 113.905 115.034 124.298 1 48.348  ? 699 ILE A O   1 
ATOM 2005 C CB  . ILE A 1 261 ? 112.445 113.406 121.756 1 51.735  ? 699 ILE A CB  1 
ATOM 2006 C CG1 . ILE A 1 261 ? 111.778 113.924 120.482 1 54.109  ? 699 ILE A CG1 1 
ATOM 2007 C CG2 . ILE A 1 261 ? 111.47  113.396 122.938 1 53.904  ? 699 ILE A CG2 1 
ATOM 2008 C CD1 . ILE A 1 261 ? 110.981 112.875 119.749 1 58.357  ? 699 ILE A CD1 1 
ATOM 2009 N N   . GLU A 1 262 ? 114.8   113.02  123.873 1 49.35   ? 700 GLU A N   1 
ATOM 2010 C CA  . GLU A 1 262 ? 115.187 112.785 125.255 1 53.618  ? 700 GLU A CA  1 
ATOM 2011 C C   . GLU A 1 262 ? 116.6   113.275 125.566 1 51.942  ? 700 GLU A C   1 
ATOM 2012 O O   . GLU A 1 262 ? 116.926 113.473 126.732 1 56.03   ? 700 GLU A O   1 
ATOM 2013 C CB  . GLU A 1 262 ? 115.128 111.296 125.572 1 56.099  ? 700 GLU A CB  1 
ATOM 2014 C CG  . GLU A 1 262 ? 113.804 110.639 125.217 1 66.209  ? 700 GLU A CG  1 
ATOM 2015 C CD  . GLU A 1 262 ? 112.741 110.79  126.278 1 78.882  ? 700 GLU A CD  1 
ATOM 2016 O OE1 . GLU A 1 262 ? 112.828 111.686 127.148 1 80.99   ? 700 GLU A OE1 1 
ATOM 2017 O OE2 . GLU A 1 262 ? 111.829 109.945 126.227 1 89.085  ? 700 GLU A OE2 1 
ATOM 2018 N N   . GLY A 1 263 ? 117.442 113.436 124.538 1 51.1    ? 701 GLY A N   1 
ATOM 2019 C CA  . GLY A 1 263 ? 118.855 113.711 124.741 1 46.327  ? 701 GLY A CA  1 
ATOM 2020 C C   . GLY A 1 263 ? 119.675 112.432 124.896 1 44.643  ? 701 GLY A C   1 
ATOM 2021 O O   . GLY A 1 263 ? 119.157 111.365 125.216 1 49.098  ? 701 GLY A O   1 
ATOM 2022 N N   . ARG A 1 264 ? 120.978 112.557 124.646 1 46.08   ? 702 ARG A N   1 
ATOM 2023 C CA  . ARG A 1 264 ? 121.927 111.469 124.815 1 46.118  ? 702 ARG A CA  1 
ATOM 2024 C C   . ARG A 1 264 ? 123.291 112.117 124.999 1 46.989  ? 702 ARG A C   1 
ATOM 2025 O O   . ARG A 1 264 ? 123.656 112.999 124.227 1 47.903  ? 702 ARG A O   1 
ATOM 2026 C CB  . ARG A 1 264 ? 121.932 110.535 123.603 1 46.397  ? 702 ARG A CB  1 
ATOM 2027 C CG  . ARG A 1 264 ? 122.815 109.3   123.737 1 50.096  ? 702 ARG A CG  1 
ATOM 2028 C CD  . ARG A 1 264 ? 122.369 108.184 122.832 1 52.817  ? 702 ARG A CD  1 
ATOM 2029 N NE  . ARG A 1 264 ? 122.97  106.896 123.196 1 56.627  ? 702 ARG A NE  1 
ATOM 2030 C CZ  . ARG A 1 264 ? 124.144 106.431 122.767 1 59.877  ? 702 ARG A CZ  1 
ATOM 2031 N NH1 . ARG A 1 264 ? 124.846 107.076 121.855 1 58.022  ? 702 ARG A NH1 1 
ATOM 2032 N NH2 . ARG A 1 264 ? 124.608 105.287 123.229 1 59.895  ? 702 ARG A NH2 1 
ATOM 2033 N N   . GLY A 1 265 ? 124.045 111.683 126.01  1 44.771  ? 703 GLY A N   1 
ATOM 2034 C CA  . GLY A 1 265 ? 125.28  112.367 126.327 1 45.387  ? 703 GLY A CA  1 
ATOM 2035 C C   . GLY A 1 265 ? 124.932 113.734 126.89  1 44.035  ? 703 GLY A C   1 
ATOM 2036 O O   . GLY A 1 265 ? 124.16  113.82  127.839 1 49.198  ? 703 GLY A O   1 
ATOM 2037 N N   . LYS A 1 266 ? 125.481 114.79  126.295 1 40.665  ? 704 LYS A N   1 
ATOM 2038 C CA  . LYS A 1 266 ? 125.29  116.127 126.819 1 41.78   ? 704 LYS A CA  1 
ATOM 2039 C C   . LYS A 1 266 ? 124.379 116.92  125.894 1 43.06   ? 704 LYS A C   1 
ATOM 2040 O O   . LYS A 1 266 ? 124.525 116.877 124.679 1 45.497  ? 704 LYS A O   1 
ATOM 2041 C CB  . LYS A 1 266 ? 126.637 116.823 127.006 1 45.511  ? 704 LYS A CB  1 
ATOM 2042 C CG  . LYS A 1 266 ? 127.421 116.215 128.153 1 51.374  ? 704 LYS A CG  1 
ATOM 2043 C CD  . LYS A 1 266 ? 128.915 116.331 128.003 1 56.062  ? 704 LYS A CD  1 
ATOM 2044 C CE  . LYS A 1 266 ? 129.637 115.633 129.097 1 56.724  ? 704 LYS A CE  1 
ATOM 2045 N NZ  . LYS A 1 266 ? 129.374 114.195 129.091 1 51.368  ? 704 LYS A NZ  1 
ATOM 2046 N N   . SER A 1 267 ? 123.459 117.662 126.508 1 42.379  ? 705 SER A N   1 
ATOM 2047 C CA  . SER A 1 267 ? 122.591 118.587 125.808 1 41.208  ? 705 SER A CA  1 
ATOM 2048 C C   . SER A 1 267 ? 123.062 119.993 126.099 1 39.944  ? 705 SER A C   1 
ATOM 2049 O O   . SER A 1 267 ? 123.194 120.363 127.257 1 43.497  ? 705 SER A O   1 
ATOM 2050 C CB  . SER A 1 267 ? 121.163 118.432 126.233 1 42.852  ? 705 SER A CB  1 
ATOM 2051 O OG  . SER A 1 267 ? 120.744 117.093 126.052 1 42.409  ? 705 SER A OG  1 
ATOM 2052 N N   . VAL A 1 268 ? 123.306 120.765 125.04  1 38.089  ? 706 VAL A N   1 
ATOM 2053 C CA  . VAL A 1 268 ? 123.936 122.058 125.188 1 39.757  ? 706 VAL A CA  1 
ATOM 2054 C C   . VAL A 1 268 ? 123.131 123.08  124.397 1 38.67   ? 706 VAL A C   1 
ATOM 2055 O O   . VAL A 1 268 ? 122.515 122.764 123.388 1 41.729  ? 706 VAL A O   1 
ATOM 2056 C CB  . VAL A 1 268 ? 125.413 122.007 124.748 1 42.12   ? 706 VAL A CB  1 
ATOM 2057 C CG1 . VAL A 1 268 ? 126.122 123.32  125.015 1 42.793  ? 706 VAL A CG1 1 
ATOM 2058 C CG2 . VAL A 1 268 ? 126.161 120.876 125.442 1 43.379  ? 706 VAL A CG2 1 
ATOM 2059 N N   . VAL A 1 269 ? 123.154 124.314 124.886 1 38.12   ? 707 VAL A N   1 
ATOM 2060 C CA  . VAL A 1 269 ? 122.659 125.446 124.139 1 41.657  ? 707 VAL A CA  1 
ATOM 2061 C C   . VAL A 1 269 ? 123.712 126.544 124.197 1 40.585  ? 707 VAL A C   1 
ATOM 2062 O O   . VAL A 1 269 ? 124.26  126.815 125.256 1 42.698  ? 707 VAL A O   1 
ATOM 2063 C CB  . VAL A 1 269 ? 121.313 125.937 124.709 1 44.368  ? 707 VAL A CB  1 
ATOM 2064 C CG1 . VAL A 1 269 ? 121.419 126.383 126.165 1 41.27   ? 707 VAL A CG1 1 
ATOM 2065 C CG2 . VAL A 1 269 ? 120.746 127.06  123.861 1 44.033  ? 707 VAL A CG2 1 
ATOM 2066 N N   . CYS A 1 270 ? 123.958 127.187 123.059 1 40.472  ? 708 CYS A N   1 
ATOM 2067 C CA  . CYS A 1 270 ? 124.888 128.296 122.989 1 45.166  ? 708 CYS A CA  1 
ATOM 2068 C C   . CYS A 1 270 ? 124.185 129.449 122.29  1 42.723  ? 708 CYS A C   1 
ATOM 2069 O O   . CYS A 1 270 ? 123.335 129.225 121.437 1 47.015  ? 708 CYS A O   1 
ATOM 2070 C CB  . CYS A 1 270 ? 126.159 127.908 122.239 1 50.302  ? 708 CYS A CB  1 
ATOM 2071 S SG  . CYS A 1 270 ? 127.418 129.205 122.275 1 66.65   ? 708 CYS A SG  1 
ATOM 2072 N N   . GLU A 1 271 ? 124.566 130.67  122.631 1 43.121  ? 709 GLU A N   1 
ATOM 2073 C CA  . GLU A 1 271 ? 123.953 131.828 122.021 1 46.882  ? 709 GLU A CA  1 
ATOM 2074 C C   . GLU A 1 271 ? 124.966 132.958 121.94  1 42.607  ? 709 GLU A C   1 
ATOM 2075 O O   . GLU A 1 271 ? 125.944 132.98  122.674 1 44.217  ? 709 GLU A O   1 
ATOM 2076 C CB  . GLU A 1 271 ? 122.727 132.255 122.827 1 48.652  ? 709 GLU A CB  1 
ATOM 2077 C CG  . GLU A 1 271 ? 123.056 132.737 124.236 1 55.184  ? 709 GLU A CG  1 
ATOM 2078 C CD  . GLU A 1 271 ? 121.844 133.13  125.06  1 63.427  ? 709 GLU A CD  1 
ATOM 2079 O OE1 . GLU A 1 271 ? 120.882 133.687 124.485 1 65.815  ? 709 GLU A OE1 1 
ATOM 2080 O OE2 . GLU A 1 271 ? 121.859 132.89  126.287 1 65.719  ? 709 GLU A OE2 1 
ATOM 2081 N N   . ALA A 1 272 ? 124.688 133.898 121.044 1 42.157  ? 710 ALA A N   1 
ATOM 2082 C CA  . ALA A 1 272 ? 125.461 135.117 120.946 1 44.38   ? 710 ALA A CA  1 
ATOM 2083 C C   . ALA A 1 272 ? 124.586 136.188 120.307 1 45.421  ? 710 ALA A C   1 
ATOM 2084 O O   . ALA A 1 272 ? 123.555 135.883 119.703 1 50.245  ? 710 ALA A O   1 
ATOM 2085 C CB  . ALA A 1 272 ? 126.72  134.853 120.152 1 45.229  ? 710 ALA A CB  1 
ATOM 2086 N N   . VAL A 1 273 ? 125.016 137.435 120.458 1 46.517  ? 711 VAL A N   1 
ATOM 2087 C CA  . VAL A 1 273 ? 124.42  138.557 119.763 1 47.704  ? 711 VAL A CA  1 
ATOM 2088 C C   . VAL A 1 273 ? 125.508 139.261 118.966 1 47.091  ? 711 VAL A C   1 
ATOM 2089 O O   . VAL A 1 273 ? 126.486 139.722 119.543 1 50.384  ? 711 VAL A O   1 
ATOM 2090 C CB  . VAL A 1 273 ? 123.743 139.521 120.751 1 51.338  ? 711 VAL A CB  1 
ATOM 2091 C CG1 . VAL A 1 273 ? 123.192 140.752 120.043 1 52.111  ? 711 VAL A CG1 1 
ATOM 2092 C CG2 . VAL A 1 273 ? 122.646 138.824 121.54  1 51.446  ? 711 VAL A CG2 1 
ATOM 2093 N N   . ILE A 1 274 ? 125.302 139.353 117.648 1 48.496  ? 712 ILE A N   1 
ATOM 2094 C CA  . ILE A 1 274 ? 126.234 140.007 116.748 1 50.809  ? 712 ILE A CA  1 
ATOM 2095 C C   . ILE A 1 274 ? 125.701 141.403 116.459 1 52.009  ? 712 ILE A C   1 
ATOM 2096 O O   . ILE A 1 274 ? 124.613 141.532 115.92  1 52.853  ? 712 ILE A O   1 
ATOM 2097 C CB  . ILE A 1 274 ? 126.398 139.187 115.457 1 50.47   ? 712 ILE A CB  1 
ATOM 2098 C CG1 . ILE A 1 274 ? 126.493 137.689 115.737 1 51.089  ? 712 ILE A CG1 1 
ATOM 2099 C CG2 . ILE A 1 274 ? 127.583 139.688 114.638 1 50.219  ? 712 ILE A CG2 1 
ATOM 2100 C CD1 . ILE A 1 274 ? 127.602 137.3   116.698 1 53.913  ? 712 ILE A CD1 1 
ATOM 2101 N N   . PRO A 1 275 ? 126.425 142.494 116.795 1 56.008  ? 713 PRO A N   1 
ATOM 2102 C CA  . PRO A 1 275 ? 125.999 143.828 116.393 1 56.132  ? 713 PRO A CA  1 
ATOM 2103 C C   . PRO A 1 275 ? 125.799 143.946 114.886 1 54.617  ? 713 PRO A C   1 
ATOM 2104 O O   . PRO A 1 275 ? 126.477 143.277 114.115 1 56.62   ? 713 PRO A O   1 
ATOM 2105 C CB  . PRO A 1 275 ? 127.126 144.734 116.884 1 59.103  ? 713 PRO A CB  1 
ATOM 2106 C CG  . PRO A 1 275 ? 127.758 143.932 118.011 1 56.892  ? 713 PRO A CG  1 
ATOM 2107 C CD  . PRO A 1 275 ? 127.662 142.504 117.586 1 56.474  ? 713 PRO A CD  1 
ATOM 2108 N N   . ALA A 1 276 ? 124.886 144.833 114.483 1 57.473  ? 714 ALA A N   1 
ATOM 2109 C CA  . ALA A 1 276 ? 124.58  145.067 113.082 1 57.101  ? 714 ALA A CA  1 
ATOM 2110 C C   . ALA A 1 276 ? 125.832 145.437 112.295 1 56.752  ? 714 ALA A C   1 
ATOM 2111 O O   . ALA A 1 276 ? 126.022 144.949 111.184 1 58.02   ? 714 ALA A O   1 
ATOM 2112 C CB  . ALA A 1 276 ? 123.541 146.156 112.97  1 58.972  ? 714 ALA A CB  1 
ATOM 2113 N N   . LYS A 1 277 ? 126.662 146.313 112.87  1 59.42   ? 715 LYS A N   1 
ATOM 2114 C CA  . LYS A 1 277 ? 127.853 146.797 112.194 1 62.69   ? 715 LYS A CA  1 
ATOM 2115 C C   . LYS A 1 277 ? 128.781 145.625 111.901 1 61.262  ? 715 LYS A C   1 
ATOM 2116 O O   . LYS A 1 277 ? 129.366 145.541 110.826 1 64.472  ? 715 LYS A O   1 
ATOM 2117 C CB  . LYS A 1 277 ? 128.525 147.878 113.047 1 68.447  ? 715 LYS A CB  1 
ATOM 2118 C CG  . LYS A 1 277 ? 129.992 148.134 112.755 1 77.533  ? 715 LYS A CG  1 
ATOM 2119 C CD  . LYS A 1 277 ? 130.533 149.31  113.565 1 84.392  ? 715 LYS A CD  1 
ATOM 2120 C CE  . LYS A 1 277 ? 132.024 149.48  113.512 1 89.099  ? 715 LYS A CE  1 
ATOM 2121 N NZ  . LYS A 1 277 ? 132.494 149.846 112.173 1 91.055  ? 715 LYS A NZ  1 
ATOM 2122 N N   . VAL A 1 278 ? 128.912 144.729 112.878 1 57.535  ? 716 VAL A N   1 
ATOM 2123 C CA  . VAL A 1 278 ? 129.775 143.575 112.734 1 56.749  ? 716 VAL A CA  1 
ATOM 2124 C C   . VAL A 1 278 ? 129.204 142.632 111.683 1 58.997  ? 716 VAL A C   1 
ATOM 2125 O O   . VAL A 1 278 ? 129.945 142.055 110.902 1 59.144  ? 716 VAL A O   1 
ATOM 2126 C CB  . VAL A 1 278 ? 129.965 142.877 114.089 1 59.115  ? 716 VAL A CB  1 
ATOM 2127 C CG1 . VAL A 1 278 ? 130.729 141.575 113.946 1 57.544  ? 716 VAL A CG1 1 
ATOM 2128 C CG2 . VAL A 1 278 ? 130.661 143.801 115.079 1 59.627  ? 716 VAL A CG2 1 
ATOM 2129 N N   . VAL A 1 279 ? 127.882 142.487 111.647 1 58.773  ? 717 VAL A N   1 
ATOM 2130 C CA  . VAL A 1 279 ? 127.258 141.666 110.628 1 60.3    ? 717 VAL A CA  1 
ATOM 2131 C C   . VAL A 1 279 ? 127.54  142.258 109.247 1 57.402  ? 717 VAL A C   1 
ATOM 2132 O O   . VAL A 1 279 ? 127.757 141.512 108.303 1 54.417  ? 717 VAL A O   1 
ATOM 2133 C CB  . VAL A 1 279 ? 125.749 141.5   110.883 1 60.208  ? 717 VAL A CB  1 
ATOM 2134 C CG1 . VAL A 1 279 ? 125.071 140.802 109.724 1 57.334  ? 717 VAL A CG1 1 
ATOM 2135 C CG2 . VAL A 1 279 ? 125.471 140.73  112.165 1 59.331  ? 717 VAL A CG2 1 
ATOM 2136 N N   . ARG A 1 280 ? 127.564 143.586 109.131 1 61.584  ? 718 ARG A N   1 
ATOM 2137 C CA  . ARG A 1 280 ? 127.855 144.23  107.858 1 65.322  ? 718 ARG A CA  1 
ATOM 2138 C C   . ARG A 1 280 ? 129.312 144.025 107.438 1 67.159  ? 718 ARG A C   1 
ATOM 2139 O O   . ARG A 1 280 ? 129.575 143.652 106.299 1 73.662  ? 718 ARG A O   1 
ATOM 2140 C CB  . ARG A 1 280 ? 127.538 145.726 107.908 1 70.982  ? 718 ARG A CB  1 
ATOM 2141 C CG  . ARG A 1 280 ? 126.116 146.046 107.478 1 80.698  ? 718 ARG A CG  1 
ATOM 2142 C CD  . ARG A 1 280 ? 125.86  147.538 107.393 1 87.037  ? 718 ARG A CD  1 
ATOM 2143 N NE  . ARG A 1 280 ? 125.595 148.107 108.719 1 90.143  ? 718 ARG A NE  1 
ATOM 2144 C CZ  . ARG A 1 280 ? 126.385 148.934 109.397 1 94.37   ? 718 ARG A CZ  1 
ATOM 2145 N NH1 . ARG A 1 280 ? 127.567 149.294 108.923 1 99.573  ? 718 ARG A NH1 1 
ATOM 2146 N NH2 . ARG A 1 280 ? 125.985 149.4   110.567 1 94.917  ? 718 ARG A NH2 1 
ATOM 2147 N N   . GLU A 1 281 ? 130.258 144.274 108.347 1 68.498  ? 719 GLU A N   1 
ATOM 2148 C CA  . GLU A 1 281 ? 131.657 144.42  107.97  1 69.701  ? 719 GLU A CA  1 
ATOM 2149 C C   . GLU A 1 281 ? 132.39  143.085 107.937 1 66.163  ? 719 GLU A C   1 
ATOM 2150 O O   . GLU A 1 281 ? 133.24  142.871 107.077 1 70.273  ? 719 GLU A O   1 
ATOM 2151 C CB  . GLU A 1 281 ? 132.365 145.371 108.927 1 74.668  ? 719 GLU A CB  1 
ATOM 2152 C CG  . GLU A 1 281 ? 132.313 146.812 108.44  1 84.706  ? 719 GLU A CG  1 
ATOM 2153 C CD  . GLU A 1 281 ? 132.282 147.807 109.577 1 92.338  ? 719 GLU A CD  1 
ATOM 2154 O OE1 . GLU A 1 281 ? 131.537 148.797 109.443 1 97.343  ? 719 GLU A OE1 1 
ATOM 2155 O OE2 . GLU A 1 281 ? 132.971 147.585 110.597 1 90.645  ? 719 GLU A OE2 1 
ATOM 2156 N N   . VAL A 1 282 ? 132.09  142.203 108.891 1 60.595  ? 720 VAL A N   1 
ATOM 2157 C CA  . VAL A 1 282 ? 132.788 140.936 108.981 1 59.241  ? 720 VAL A CA  1 
ATOM 2158 C C   . VAL A 1 282 ? 132.069 139.876 108.152 1 60.37   ? 720 VAL A C   1 
ATOM 2159 O O   . VAL A 1 282 ? 132.711 139.117 107.439 1 64.613  ? 720 VAL A O   1 
ATOM 2160 C CB  . VAL A 1 282 ? 132.922 140.512 110.45  1 60.754  ? 720 VAL A CB  1 
ATOM 2161 C CG1 . VAL A 1 282 ? 133.521 139.122 110.585 1 60.477  ? 720 VAL A CG1 1 
ATOM 2162 C CG2 . VAL A 1 282 ? 133.733 141.53  111.235 1 61.556  ? 720 VAL A CG2 1 
ATOM 2163 N N   . LEU A 1 283 ? 130.74  139.819 108.257 1 59.694  ? 721 LEU A N   1 
ATOM 2164 C CA  . LEU A 1 283 ? 129.967 138.779 107.597 1 60.477  ? 721 LEU A CA  1 
ATOM 2165 C C   . LEU A 1 283 ? 129.47  139.217 106.222 1 59.128  ? 721 LEU A C   1 
ATOM 2166 O O   . LEU A 1 283 ? 128.98  138.383 105.471 1 59.885  ? 721 LEU A O   1 
ATOM 2167 C CB  . LEU A 1 283 ? 128.816 138.38  108.512 1 59.55   ? 721 LEU A CB  1 
ATOM 2168 C CG  . LEU A 1 283 ? 129.25  137.85  109.88  1 60.292  ? 721 LEU A CG  1 
ATOM 2169 C CD1 . LEU A 1 283 ? 128.06  137.451 110.717 1 59.066  ? 721 LEU A CD1 1 
ATOM 2170 C CD2 . LEU A 1 283 ? 130.214 136.686 109.742 1 58.319  ? 721 LEU A CD2 1 
ATOM 2171 N N   . LYS A 1 284 ? 129.604 140.507 105.889 1 64.203  ? 722 LYS A N   1 
ATOM 2172 C CA  . LYS A 1 284 ? 129.331 140.995 104.543 1 66.135  ? 722 LYS A CA  1 
ATOM 2173 C C   . LYS A 1 284 ? 127.867 140.765 104.172 1 66.158  ? 722 LYS A C   1 
ATOM 2174 O O   . LYS A 1 284 ? 127.562 140.421 103.034 1 73.542  ? 722 LYS A O   1 
ATOM 2175 C CB  . LYS A 1 284 ? 130.248 140.322 103.512 1 70.057  ? 722 LYS A CB  1 
ATOM 2176 C CG  . LYS A 1 284 ? 131.737 140.519 103.741 1 75.792  ? 722 LYS A CG  1 
ATOM 2177 C CD  . LYS A 1 284 ? 132.163 141.981 103.732 1 82.614  ? 722 LYS A CD  1 
ATOM 2178 C CE  . LYS A 1 284 ? 133.651 142.154 103.755 1 87.672  ? 722 LYS A CE  1 
ATOM 2179 N NZ  . LYS A 1 284 ? 134.25  141.59  104.966 1 86.903  ? 722 LYS A NZ  1 
ATOM 2180 N N   . THR A 1 285 ? 126.961 140.968 105.132 1 63.877  ? 723 THR A N   1 
ATOM 2181 C CA  . THR A 1 285 ? 125.538 140.784 104.883 1 60.546  ? 723 THR A CA  1 
ATOM 2182 C C   . THR A 1 285 ? 124.755 141.693 105.826 1 57.92   ? 723 THR A C   1 
ATOM 2183 O O   . THR A 1 285 ? 125.306 142.656 106.356 1 59.311  ? 723 THR A O   1 
ATOM 2184 C CB  . THR A 1 285 ? 125.167 139.305 105.023 1 62.742  ? 723 THR A CB  1 
ATOM 2185 O OG1 . THR A 1 285 ? 123.806 139.152 104.629 1 60.819  ? 723 THR A OG1 1 
ATOM 2186 C CG2 . THR A 1 285 ? 125.337 138.777 106.436 1 62.864  ? 723 THR A CG2 1 
ATOM 2187 N N   . THR A 1 286 ? 123.459 141.403 106.001 1 55.136  ? 724 THR A N   1 
ATOM 2188 C CA  . THR A 1 286 ? 122.619 142.133 106.941 1 57.908  ? 724 THR A CA  1 
ATOM 2189 C C   . THR A 1 286 ? 121.85  141.131 107.796 1 53.683  ? 724 THR A C   1 
ATOM 2190 O O   . THR A 1 286 ? 121.713 139.965 107.448 1 54.408  ? 724 THR A O   1 
ATOM 2191 C CB  . THR A 1 286 ? 121.656 143.093 106.234 1 60.885  ? 724 THR A CB  1 
ATOM 2192 O OG1 . THR A 1 286 ? 120.607 142.32  105.657 1 61.752  ? 724 THR A OG1 1 
ATOM 2193 C CG2 . THR A 1 286 ? 122.327 143.927 105.159 1 62.784  ? 724 THR A CG2 1 
ATOM 2194 N N   . THR A 1 287 ? 121.332 141.613 108.926 1 50.83   ? 725 THR A N   1 
ATOM 2195 C CA  . THR A 1 287 ? 120.605 140.769 109.861 1 52.597  ? 725 THR A CA  1 
ATOM 2196 C C   . THR A 1 287 ? 119.339 140.208 109.216 1 54.02   ? 725 THR A C   1 
ATOM 2197 O O   . THR A 1 287 ? 119.002 139.045 109.429 1 46.656  ? 725 THR A O   1 
ATOM 2198 C CB  . THR A 1 287 ? 120.244 141.563 111.114 1 53.749  ? 725 THR A CB  1 
ATOM 2199 O OG1 . THR A 1 287 ? 121.444 141.779 111.85  1 53.269  ? 725 THR A OG1 1 
ATOM 2200 C CG2 . THR A 1 287 ? 119.259 140.817 111.994 1 53.551  ? 725 THR A CG2 1 
ATOM 2201 N N   . GLU A 1 288 ? 118.641 141.044 108.439 1 53.077  ? 726 GLU A N   1 
ATOM 2202 C CA  . GLU A 1 288 ? 117.385 140.643 107.826 1 56.663  ? 726 GLU A CA  1 
ATOM 2203 C C   . GLU A 1 288 ? 117.616 139.471 106.872 1 49.067  ? 726 GLU A C   1 
ATOM 2204 O O   . GLU A 1 288 ? 116.865 138.494 106.891 1 51.627  ? 726 GLU A O   1 
ATOM 2205 C CB  . GLU A 1 288 ? 116.737 141.824 107.105 1 62.947  ? 726 GLU A CB  1 
ATOM 2206 C CG  . GLU A 1 288 ? 116.471 143.013 108.024 1 76.866  ? 726 GLU A CG  1 
ATOM 2207 C CD  . GLU A 1 288 ? 117.701 143.776 108.5   1 84.894  ? 726 GLU A CD  1 
ATOM 2208 O OE1 . GLU A 1 288 ? 118.721 143.774 107.787 1 87.309  ? 726 GLU A OE1 1 
ATOM 2209 O OE2 . GLU A 1 288 ? 117.662 144.324 109.617 1 84.57   ? 726 GLU A OE2 1 
ATOM 2210 N N   . ALA A 1 289 ? 118.653 139.573 106.032 1 48.672  ? 727 ALA A N   1 
ATOM 2211 C CA  . ALA A 1 289 ? 118.97  138.515 105.088 1 47.268  ? 727 ALA A CA  1 
ATOM 2212 C C   . ALA A 1 289 ? 119.323 137.233 105.836 1 46.121  ? 727 ALA A C   1 
ATOM 2213 O O   . ALA A 1 289 ? 118.945 136.139 105.417 1 50.137  ? 727 ALA A O   1 
ATOM 2214 C CB  . ALA A 1 289 ? 120.095 138.947 104.172 1 46.676  ? 727 ALA A CB  1 
ATOM 2215 N N   . MET A 1 290 ? 120.075 137.367 106.931 1 47.287  ? 728 MET A N   1 
ATOM 2216 C CA  . MET A 1 290 ? 120.504 136.207 107.696 1 48.497  ? 728 MET A CA  1 
ATOM 2217 C C   . MET A 1 290 ? 119.279 135.481 108.248 1 47.053  ? 728 MET A C   1 
ATOM 2218 O O   . MET A 1 290 ? 119.193 134.258 108.172 1 44.418  ? 728 MET A O   1 
ATOM 2219 C CB  . MET A 1 290 ? 121.443 136.613 108.839 1 50.7    ? 728 MET A CB  1 
ATOM 2220 C CG  . MET A 1 290 ? 122.856 136.923 108.388 1 53.938  ? 728 MET A CG  1 
ATOM 2221 S SD  . MET A 1 290 ? 123.683 135.387 107.962 1 61.691  ? 728 MET A SD  1 
ATOM 2222 C CE  . MET A 1 290 ? 124.301 134.905 109.578 1 57.093  ? 728 MET A CE  1 
ATOM 2223 N N   . ILE A 1 291 ? 118.324 136.237 108.794 1 46.401  ? 729 ILE A N   1 
ATOM 2224 C CA  . ILE A 1 291 ? 117.137 135.629 109.367 1 48.803  ? 729 ILE A CA  1 
ATOM 2225 C C   . ILE A 1 291 ? 116.303 134.968 108.27  1 48.941  ? 729 ILE A C   1 
ATOM 2226 O O   . ILE A 1 291 ? 115.783 133.873 108.47  1 44.565  ? 729 ILE A O   1 
ATOM 2227 C CB  . ILE A 1 291 ? 116.319 136.664 110.15  1 51.402  ? 729 ILE A CB  1 
ATOM 2228 C CG1 . ILE A 1 291 ? 117.066 137.127 111.4   1 52.845  ? 729 ILE A CG1 1 
ATOM 2229 C CG2 . ILE A 1 291 ? 114.933 136.105 110.48  1 51.322  ? 729 ILE A CG2 1 
ATOM 2230 C CD1 . ILE A 1 291 ? 116.687 138.524 111.833 1 54.84   ? 729 ILE A CD1 1 
ATOM 2231 N N   . GLU A 1 292 ? 116.168 135.634 107.12  1 47.227  ? 730 GLU A N   1 
ATOM 2232 C CA  . GLU A 1 292 ? 115.405 135.078 106.016 1 50.321  ? 730 GLU A CA  1 
ATOM 2233 C C   . GLU A 1 292 ? 115.998 133.732 105.601 1 47      ? 730 GLU A C   1 
ATOM 2234 O O   . GLU A 1 292 ? 115.276 132.742 105.46  1 49.122  ? 730 GLU A O   1 
ATOM 2235 C CB  . GLU A 1 292 ? 115.388 136.062 104.844 1 55.128  ? 730 GLU A CB  1 
ATOM 2236 C CG  . GLU A 1 292 ? 114.397 135.673 103.75  1 63.456  ? 730 GLU A CG  1 
ATOM 2237 C CD  . GLU A 1 292 ? 114.414 136.574 102.526 1 76.848  ? 730 GLU A CD  1 
ATOM 2238 O OE1 . GLU A 1 292 ? 113.531 136.376 101.663 1 85.838  ? 730 GLU A OE1 1 
ATOM 2239 O OE2 . GLU A 1 292 ? 115.299 137.454 102.415 1 83.176  ? 730 GLU A OE2 1 
ATOM 2240 N N   . VAL A 1 293 ? 117.321 133.686 105.438 1 44.714  ? 731 VAL A N   1 
ATOM 2241 C CA  . VAL A 1 293 ? 117.969 132.464 105     1 47.333  ? 731 VAL A CA  1 
ATOM 2242 C C   . VAL A 1 293 ? 117.818 131.392 106.076 1 44.045  ? 731 VAL A C   1 
ATOM 2243 O O   . VAL A 1 293 ? 117.552 130.238 105.77  1 45.9    ? 731 VAL A O   1 
ATOM 2244 C CB  . VAL A 1 293 ? 119.445 132.695 104.632 1 51.982  ? 731 VAL A CB  1 
ATOM 2245 C CG1 . VAL A 1 293 ? 120.141 131.386 104.294 1 53.633  ? 731 VAL A CG1 1 
ATOM 2246 C CG2 . VAL A 1 293 ? 119.59  133.674 103.48  1 53.537  ? 731 VAL A CG2 1 
ATOM 2247 N N   . ASN A 1 294 ? 117.989 131.769 107.338 1 43.218  ? 732 ASN A N   1 
ATOM 2248 C CA  . ASN A 1 294 ? 117.889 130.804 108.418 1 44.703  ? 732 ASN A CA  1 
ATOM 2249 C C   . ASN A 1 294 ? 116.502 130.16  108.41  1 42.867  ? 732 ASN A C   1 
ATOM 2250 O O   . ASN A 1 294 ? 116.372 128.949 108.461 1 39.612  ? 732 ASN A O   1 
ATOM 2251 C CB  . ASN A 1 294 ? 118.207 131.454 109.759 1 46.82   ? 732 ASN A CB  1 
ATOM 2252 C CG  . ASN A 1 294 ? 118.198 130.441 110.875 1 51.378  ? 732 ASN A CG  1 
ATOM 2253 O OD1 . ASN A 1 294 ? 119.08  129.582 110.935 1 52.297  ? 732 ASN A OD1 1 
ATOM 2254 N ND2 . ASN A 1 294 ? 117.211 130.513 111.752 1 55.554  ? 732 ASN A ND2 1 
ATOM 2255 N N   . ILE A 1 295 ? 115.454 130.975 108.336 1 43.669  ? 733 ILE A N   1 
ATOM 2256 C CA  . ILE A 1 295 ? 114.11  130.431 108.352 1 44.113  ? 733 ILE A CA  1 
ATOM 2257 C C   . ILE A 1 295 ? 113.891 129.515 107.149 1 42.654  ? 733 ILE A C   1 
ATOM 2258 O O   . ILE A 1 295 ? 113.416 128.399 107.299 1 41.048  ? 733 ILE A O   1 
ATOM 2259 C CB  . ILE A 1 295 ? 113.059 131.548 108.401 1 47.304  ? 733 ILE A CB  1 
ATOM 2260 C CG1 . ILE A 1 295 ? 113.016 132.208 109.778 1 46.189  ? 733 ILE A CG1 1 
ATOM 2261 C CG2 . ILE A 1 295 ? 111.692 130.995 107.999 1 46.433  ? 733 ILE A CG2 1 
ATOM 2262 C CD1 . ILE A 1 295 ? 112.448 133.61  109.747 1 50.459  ? 733 ILE A CD1 1 
ATOM 2263 N N   . ASN A 1 296 ? 114.235 129.984 105.954 1 42.623  ? 734 ASN A N   1 
ATOM 2264 C CA  . ASN A 1 296 ? 113.826 129.297 104.738 1 45.505  ? 734 ASN A CA  1 
ATOM 2265 C C   . ASN A 1 296 ? 114.778 128.166 104.359 1 45.23   ? 734 ASN A C   1 
ATOM 2266 O O   . ASN A 1 296 ? 114.458 127.409 103.448 1 52.032  ? 734 ASN A O   1 
ATOM 2267 C CB  . ASN A 1 296 ? 113.618 130.296 103.608 1 45.038  ? 734 ASN A CB  1 
ATOM 2268 C CG  . ASN A 1 296 ? 112.489 131.242 103.941 1 46.773  ? 734 ASN A CG  1 
ATOM 2269 O OD1 . ASN A 1 296 ? 111.398 130.772 104.27  1 46.176  ? 734 ASN A OD1 1 
ATOM 2270 N ND2 . ASN A 1 296 ? 112.709 132.548 103.891 1 50.973  ? 734 ASN A ND2 1 
ATOM 2271 N N   . LYS A 1 297 ? 115.924 128.034 105.04  1 46.633  ? 735 LYS A N   1 
ATOM 2272 C CA  . LYS A 1 297 ? 116.836 126.927 104.782 1 45.76   ? 735 LYS A CA  1 
ATOM 2273 C C   . LYS A 1 297 ? 116.864 125.963 105.971 1 45.029  ? 735 LYS A C   1 
ATOM 2274 O O   . LYS A 1 297 ? 116.641 124.773 105.789 1 47.719  ? 735 LYS A O   1 
ATOM 2275 C CB  . LYS A 1 297 ? 118.241 127.459 104.465 1 49.684  ? 735 LYS A CB  1 
ATOM 2276 C CG  . LYS A 1 297 ? 119.347 126.404 104.378 1 50.842  ? 735 LYS A CG  1 
ATOM 2277 C CD  . LYS A 1 297 ? 120.746 127.014 104.467 1 50.373  ? 735 LYS A CD  1 
ATOM 2278 C CE  . LYS A 1 297 ? 121.857 126.009 104.611 1 49.057  ? 735 LYS A CE  1 
ATOM 2279 N NZ  . LYS A 1 297 ? 121.891 125     103.553 1 49.659  ? 735 LYS A NZ  1 
ATOM 2280 N N   . ASN A 1 298 ? 117.168 126.452 107.178 1 44.417  ? 736 ASN A N   1 
ATOM 2281 C CA  . ASN A 1 298 ? 117.418 125.558 108.299 1 48.242  ? 736 ASN A CA  1 
ATOM 2282 C C   . ASN A 1 298 ? 116.109 125.027 108.885 1 45.363  ? 736 ASN A C   1 
ATOM 2283 O O   . ASN A 1 298 ? 116.108 123.94  109.464 1 48.707  ? 736 ASN A O   1 
ATOM 2284 C CB  . ASN A 1 298 ? 118.277 126.222 109.369 1 47.144  ? 736 ASN A CB  1 
ATOM 2285 C CG  . ASN A 1 298 ? 119.718 126.334 108.935 1 53.554  ? 736 ASN A CG  1 
ATOM 2286 O OD1 . ASN A 1 298 ? 120.191 125.535 108.118 1 56.15   ? 736 ASN A OD1 1 
ATOM 2287 N ND2 . ASN A 1 298 ? 120.446 127.271 109.519 1 57.438  ? 736 ASN A ND2 1 
ATOM 2288 N N   . LEU A 1 299 ? 115.027 125.807 108.787 1 40.578  ? 737 LEU A N   1 
ATOM 2289 C CA  . LEU A 1 299 ? 113.741 125.376 109.308 1 40.456  ? 737 LEU A CA  1 
ATOM 2290 C C   . LEU A 1 299 ? 112.887 124.791 108.186 1 38.515  ? 737 LEU A C   1 
ATOM 2291 O O   . LEU A 1 299 ? 112.517 123.63  108.256 1 39.687  ? 737 LEU A O   1 
ATOM 2292 C CB  . LEU A 1 299 ? 113.042 126.535 110.01  1 43.259  ? 737 LEU A CB  1 
ATOM 2293 C CG  . LEU A 1 299 ? 113.816 127.174 111.166 1 48.09   ? 737 LEU A CG  1 
ATOM 2294 C CD1 . LEU A 1 299 ? 112.961 128.171 111.919 1 48.194  ? 737 LEU A CD1 1 
ATOM 2295 C CD2 . LEU A 1 299 ? 114.344 126.135 112.127 1 50.588  ? 737 LEU A CD2 1 
ATOM 2296 N N   . VAL A 1 300 ? 112.531 125.597 107.178 1 39.55   ? 738 VAL A N   1 
ATOM 2297 C CA  . VAL A 1 300 ? 111.57  125.153 106.179 1 38.367  ? 738 VAL A CA  1 
ATOM 2298 C C   . VAL A 1 300 ? 112.215 124.116 105.264 1 37.318  ? 738 VAL A C   1 
ATOM 2299 O O   . VAL A 1 300 ? 111.636 123.065 105.02  1 40.843  ? 738 VAL A O   1 
ATOM 2300 C CB  . VAL A 1 300 ? 110.985 126.326 105.38  1 40.486  ? 738 VAL A CB  1 
ATOM 2301 C CG1 . VAL A 1 300 ? 109.992 125.844 104.331 1 41.817  ? 738 VAL A CG1 1 
ATOM 2302 C CG2 . VAL A 1 300 ? 110.335 127.349 106.295 1 40.422  ? 738 VAL A CG2 1 
ATOM 2303 N N   . GLY A 1 301 ? 113.422 124.39  104.767 1 39.899  ? 739 GLY A N   1 
ATOM 2304 C CA  . GLY A 1 301 ? 114.113 123.44  103.91  1 38.904  ? 739 GLY A CA  1 
ATOM 2305 C C   . GLY A 1 301 ? 114.28  122.083 104.58  1 38.353  ? 739 GLY A C   1 
ATOM 2306 O O   . GLY A 1 301 ? 114.058 121.051 103.963 1 41.506  ? 739 GLY A O   1 
ATOM 2307 N N   . SER A 1 302 ? 114.693 122.08  105.845 1 39.85   ? 740 SER A N   1 
ATOM 2308 C CA  . SER A 1 302 ? 114.864 120.838 106.579 1 40.973  ? 740 SER A CA  1 
ATOM 2309 C C   . SER A 1 302 ? 113.524 120.127 106.767 1 38.076  ? 740 SER A C   1 
ATOM 2310 O O   . SER A 1 302 ? 113.464 118.905 106.692 1 38.582  ? 740 SER A O   1 
ATOM 2311 C CB  . SER A 1 302 ? 115.539 121.093 107.908 1 43.69   ? 740 SER A CB  1 
ATOM 2312 O OG  . SER A 1 302 ? 116.863 121.571 107.709 1 48.092  ? 740 SER A OG  1 
ATOM 2313 N N   . ALA A 1 303 ? 112.455 120.89  107.028 1 36.691  ? 741 ALA A N   1 
ATOM 2314 C CA  . ALA A 1 303 ? 111.122 120.323 107.177 1 39.526  ? 741 ALA A CA  1 
ATOM 2315 C C   . ALA A 1 303 ? 110.669 119.652 105.88  1 39.254  ? 741 ALA A C   1 
ATOM 2316 O O   . ALA A 1 303 ? 110.159 118.537 105.92  1 39.512  ? 741 ALA A O   1 
ATOM 2317 C CB  . ALA A 1 303 ? 110.141 121.391 107.615 1 43.782  ? 741 ALA A CB  1 
ATOM 2318 N N   . MET A 1 304 ? 110.909 120.3   104.73  1 41.829  ? 742 MET A N   1 
ATOM 2319 C CA  . MET A 1 304 ? 110.501 119.743 103.445 1 42.104  ? 742 MET A CA  1 
ATOM 2320 C C   . MET A 1 304 ? 111.312 118.489 103.124 1 41.932  ? 742 MET A C   1 
ATOM 2321 O O   . MET A 1 304 ? 110.806 117.581 102.472 1 46.456  ? 742 MET A O   1 
ATOM 2322 C CB  . MET A 1 304 ? 110.664 120.754 102.307 1 43.164  ? 742 MET A CB  1 
ATOM 2323 C CG  . MET A 1 304 ? 109.91  122.056 102.52  1 44.376  ? 742 MET A CG  1 
ATOM 2324 S SD  . MET A 1 304 ? 108.207 121.794 103.067 1 48.406  ? 742 MET A SD  1 
ATOM 2325 C CE  . MET A 1 304 ? 107.557 120.734 101.771 1 51.024  ? 742 MET A CE  1 
ATOM 2326 N N   . ALA A 1 305 ? 112.56  118.418 103.602 1 44.065  ? 743 ALA A N   1 
ATOM 2327 C CA  . ALA A 1 305 ? 113.4   117.247 103.389 1 42.612  ? 743 ALA A CA  1 
ATOM 2328 C C   . ALA A 1 305 ? 113.046 116.128 104.363 1 43.799  ? 743 ALA A C   1 
ATOM 2329 O O   . ALA A 1 305 ? 113.559 115.019 104.237 1 45.702  ? 743 ALA A O   1 
ATOM 2330 C CB  . ALA A 1 305 ? 114.861 117.629 103.53  1 44.685  ? 743 ALA A CB  1 
ATOM 2331 N N   . GLY A 1 306 ? 112.18  116.408 105.341 1 43.636  ? 744 GLY A N   1 
ATOM 2332 C CA  . GLY A 1 306 ? 111.777 115.381 106.288 1 43.938  ? 744 GLY A CA  1 
ATOM 2333 C C   . GLY A 1 306 ? 112.911 115.049 107.255 1 45.972  ? 744 GLY A C   1 
ATOM 2334 O O   . GLY A 1 306 ? 113.217 113.883 107.488 1 47.502  ? 744 GLY A O   1 
ATOM 2335 N N   . SER A 1 307 ? 113.54  116.094 107.789 1 47.895  ? 745 SER A N   1 
ATOM 2336 C CA  . SER A 1 307 ? 114.65  115.94  108.712 1 53.769  ? 745 SER A CA  1 
ATOM 2337 C C   . SER A 1 307 ? 114.159 115.816 110.152 1 52.741  ? 745 SER A C   1 
ATOM 2338 O O   . SER A 1 307 ? 113.294 116.576 110.589 1 55.77   ? 745 SER A O   1 
ATOM 2339 C CB  . SER A 1 307 ? 115.588 117.093 108.603 1 56.167  ? 745 SER A CB  1 
ATOM 2340 O OG  . SER A 1 307 ? 116.777 116.827 109.324 1 60.894  ? 745 SER A OG  1 
ATOM 2341 N N   . ILE A 1 308 ? 114.755 114.873 110.886 1 51.504  ? 746 ILE A N   1 
ATOM 2342 C CA  . ILE A 1 308 ? 114.654 114.835 112.334 1 53.04   ? 746 ILE A CA  1 
ATOM 2343 C C   . ILE A 1 308 ? 115.996 115.27  112.913 1 49.865  ? 746 ILE A C   1 
ATOM 2344 O O   . ILE A 1 308 ? 116.978 114.546 112.816 1 52.916  ? 746 ILE A O   1 
ATOM 2345 C CB  . ILE A 1 308 ? 114.288 113.431 112.833 1 54.837  ? 746 ILE A CB  1 
ATOM 2346 C CG1 . ILE A 1 308 ? 112.978 112.912 112.229 1 61.011  ? 746 ILE A CG1 1 
ATOM 2347 C CG2 . ILE A 1 308 ? 114.257 113.431 114.359 1 55.371  ? 746 ILE A CG2 1 
ATOM 2348 C CD1 . ILE A 1 308 ? 111.732 113.595 112.759 1 65.588  ? 746 ILE A CD1 1 
ATOM 2349 N N   . GLY A 1 309 ? 116.038 116.46  113.501 1 50.562  ? 747 GLY A N   1 
ATOM 2350 C CA  . GLY A 1 309 ? 117.229 116.914 114.196 1 51.448  ? 747 GLY A CA  1 
ATOM 2351 C C   . GLY A 1 309 ? 118.265 117.559 113.277 1 51.288  ? 747 GLY A C   1 
ATOM 2352 O O   . GLY A 1 309 ? 119.312 117.973 113.746 1 50.847  ? 747 GLY A O   1 
ATOM 2353 N N   . GLY A 1 310 ? 117.956 117.718 111.987 1 49.028  ? 748 GLY A N   1 
ATOM 2354 C CA  . GLY A 1 310 ? 118.905 118.291 111.043 1 43.678  ? 748 GLY A CA  1 
ATOM 2355 C C   . GLY A 1 310 ? 118.557 119.727 110.662 1 43.104  ? 748 GLY A C   1 
ATOM 2356 O O   . GLY A 1 310 ? 118.655 120.101 109.497 1 45.337  ? 748 GLY A O   1 
ATOM 2357 N N   . TYR A 1 311 ? 118.193 120.548 111.648 1 38.299  ? 749 TYR A N   1 
ATOM 2358 C CA  . TYR A 1 311 ? 117.743 121.898 111.377 1 38.674  ? 749 TYR A CA  1 
ATOM 2359 C C   . TYR A 1 311 ? 118.903 122.876 111.51  1 40.075  ? 749 TYR A C   1 
ATOM 2360 O O   . TYR A 1 311 ? 118.832 123.839 112.273 1 38.782  ? 749 TYR A O   1 
ATOM 2361 C CB  . TYR A 1 311 ? 116.591 122.246 112.312 1 40.464  ? 749 TYR A CB  1 
ATOM 2362 C CG  . TYR A 1 311 ? 115.393 121.334 112.124 1 44.456  ? 749 TYR A CG  1 
ATOM 2363 C CD1 . TYR A 1 311 ? 115.273 120.155 112.841 1 47.05   ? 749 TYR A CD1 1 
ATOM 2364 C CD2 . TYR A 1 311 ? 114.393 121.665 111.224 1 47.04   ? 749 TYR A CD2 1 
ATOM 2365 C CE1 . TYR A 1 311 ? 114.184 119.317 112.657 1 52.105  ? 749 TYR A CE1 1 
ATOM 2366 C CE2 . TYR A 1 311 ? 113.294 120.844 111.04  1 50.678  ? 749 TYR A CE2 1 
ATOM 2367 C CZ  . TYR A 1 311 ? 113.194 119.667 111.758 1 53.098  ? 749 TYR A CZ  1 
ATOM 2368 O OH  . TYR A 1 311 ? 112.101 118.868 111.592 1 64.692  ? 749 TYR A OH  1 
ATOM 2369 N N   . ASN A 1 312 ? 119.946 122.634 110.714 1 39.757  ? 750 ASN A N   1 
ATOM 2370 C CA  . ASN A 1 312 ? 121.158 123.433 110.765 1 41.186  ? 750 ASN A CA  1 
ATOM 2371 C C   . ASN A 1 312 ? 121.834 123.398 109.401 1 39.815  ? 750 ASN A C   1 
ATOM 2372 O O   . ASN A 1 312 ? 121.459 122.622 108.53  1 40.038  ? 750 ASN A O   1 
ATOM 2373 C CB  . ASN A 1 312 ? 122.11  122.91  111.837 1 39.481  ? 750 ASN A CB  1 
ATOM 2374 C CG  . ASN A 1 312 ? 122.545 121.493 111.56  1 36.728  ? 750 ASN A CG  1 
ATOM 2375 O OD1 . ASN A 1 312 ? 123.556 121.259 110.892 1 40.239  ? 750 ASN A OD1 1 
ATOM 2376 N ND2 . ASN A 1 312 ? 121.79  120.52  112.03  1 37.987  ? 750 ASN A ND2 1 
ATOM 2377 N N   . ALA A 1 313 ? 122.86  124.231 109.234 1 43.087  ? 751 ALA A N   1 
ATOM 2378 C CA  . ALA A 1 313 ? 123.573 124.322 107.971 1 45.039  ? 751 ALA A CA  1 
ATOM 2379 C C   . ALA A 1 313 ? 124.596 123.188 107.84  1 50.29   ? 751 ALA A C   1 
ATOM 2380 O O   . ALA A 1 313 ? 124.444 122.344 106.96  1 49.297  ? 751 ALA A O   1 
ATOM 2381 C CB  . ALA A 1 313 ? 124.19  125.681 107.839 1 46.893  ? 751 ALA A CB  1 
ATOM 2382 N N   . HIS A 1 314 ? 125.625 123.138 108.704 1 46.676  ? 752 HIS A N   1 
ATOM 2383 C CA  . HIS A 1 314 ? 126.663 122.13  108.547 1 48.33   ? 752 HIS A CA  1 
ATOM 2384 C C   . HIS A 1 314 ? 127.311 121.773 109.881 1 46.06   ? 752 HIS A C   1 
ATOM 2385 O O   . HIS A 1 314 ? 128.51  121.59  109.955 1 45.171  ? 752 HIS A O   1 
ATOM 2386 C CB  . HIS A 1 314 ? 127.73  122.601 107.552 1 48.843  ? 752 HIS A CB  1 
ATOM 2387 C CG  . HIS A 1 314 ? 128.528 123.771 107.996 1 50.126  ? 752 HIS A CG  1 
ATOM 2388 N ND1 . HIS A 1 314 ? 129.861 123.899 107.668 1 54.137  ? 752 HIS A ND1 1 
ATOM 2389 C CD2 . HIS A 1 314 ? 128.216 124.853 108.722 1 54.34   ? 752 HIS A CD2 1 
ATOM 2390 C CE1 . HIS A 1 314 ? 130.32  125.044 108.172 1 55.076  ? 752 HIS A CE1 1 
ATOM 2391 N NE2 . HIS A 1 314 ? 129.337 125.643 108.81  1 53.051  ? 752 HIS A NE2 1 
ATOM 2392 N N   . ALA A 1 315 ? 126.51  121.597 110.927 1 45.131  ? 753 ALA A N   1 
ATOM 2393 C CA  . ALA A 1 315 ? 127.039 121.217 112.223 1 43.688  ? 753 ALA A CA  1 
ATOM 2394 C C   . ALA A 1 315 ? 127.911 119.963 112.141 1 39.409  ? 753 ALA A C   1 
ATOM 2395 O O   . ALA A 1 315 ? 128.891 119.853 112.862 1 41.064  ? 753 ALA A O   1 
ATOM 2396 C CB  . ALA A 1 315 ? 125.905 121.039 113.19  1 42.189  ? 753 ALA A CB  1 
ATOM 2397 N N   . ALA A 1 316 ? 127.583 119.032 111.251 1 37.879  ? 754 ALA A N   1 
ATOM 2398 C CA  . ALA A 1 316 ? 128.325 117.788 111.128 1 40.283  ? 754 ALA A CA  1 
ATOM 2399 C C   . ALA A 1 316 ? 129.786 118.02  110.743 1 40.964  ? 754 ALA A C   1 
ATOM 2400 O O   . ALA A 1 316 ? 130.655 117.299 111.229 1 43.889  ? 754 ALA A O   1 
ATOM 2401 C CB  . ALA A 1 316 ? 127.641 116.876 110.138 1 38.813  ? 754 ALA A CB  1 
ATOM 2402 N N   . ASN A 1 317 ? 130.049 119.035 109.915 1 40.488  ? 755 ASN A N   1 
ATOM 2403 C CA  . ASN A 1 317 ? 131.408 119.38  109.521 1 43.79   ? 755 ASN A CA  1 
ATOM 2404 C C   . ASN A 1 317 ? 132.256 119.689 110.75  1 39.163  ? 755 ASN A C   1 
ATOM 2405 O O   . ASN A 1 317 ? 133.296 119.074 110.951 1 42.378  ? 755 ASN A O   1 
ATOM 2406 C CB  . ASN A 1 317 ? 131.435 120.571 108.564 1 45.315  ? 755 ASN A CB  1 
ATOM 2407 C CG  . ASN A 1 317 ? 131.198 120.176 107.127 1 54.625  ? 755 ASN A CG  1 
ATOM 2408 O OD1 . ASN A 1 317 ? 131.434 119.026 106.736 1 58.207  ? 755 ASN A OD1 1 
ATOM 2409 N ND2 . ASN A 1 317 ? 130.81  121.136 106.305 1 60.361  ? 755 ASN A ND2 1 
ATOM 2410 N N   . ILE A 1 318 ? 131.786 120.627 111.577 1 41.504  ? 756 ILE A N   1 
ATOM 2411 C CA  . ILE A 1 318 ? 132.539 121.104 112.722 1 41.791  ? 756 ILE A CA  1 
ATOM 2412 C C   . ILE A 1 318 ? 132.675 119.964 113.716 1 41.28   ? 756 ILE A C   1 
ATOM 2413 O O   . ILE A 1 318 ? 133.746 119.736 114.267 1 45.251  ? 756 ILE A O   1 
ATOM 2414 C CB  . ILE A 1 318 ? 131.896 122.358 113.348 1 45.453  ? 756 ILE A CB  1 
ATOM 2415 C CG1 . ILE A 1 318 ? 132.218 123.615 112.566 1 53.417  ? 756 ILE A CG1 1 
ATOM 2416 C CG2 . ILE A 1 318 ? 132.336 122.557 114.794 1 42.765  ? 756 ILE A CG2 1 
ATOM 2417 C CD1 . ILE A 1 318 ? 131.577 123.694 111.212 1 56.714  ? 756 ILE A CD1 1 
ATOM 2418 N N   . VAL A 1 319 ? 131.572 119.254 113.95  1 39.365  ? 757 VAL A N   1 
ATOM 2419 C CA  . VAL A 1 319 ? 131.568 118.208 114.951 1 39.47   ? 757 VAL A CA  1 
ATOM 2420 C C   . VAL A 1 319 ? 132.581 117.143 114.559 1 39.315  ? 757 VAL A C   1 
ATOM 2421 O O   . VAL A 1 319 ? 133.352 116.703 115.404 1 39.712  ? 757 VAL A O   1 
ATOM 2422 C CB  . VAL A 1 319 ? 130.164 117.61  115.158 1 39.084  ? 757 VAL A CB  1 
ATOM 2423 C CG1 . VAL A 1 319 ? 130.216 116.304 115.924 1 38.566  ? 757 VAL A CG1 1 
ATOM 2424 C CG2 . VAL A 1 319 ? 129.237 118.585 115.858 1 40.687  ? 757 VAL A CG2 1 
ATOM 2425 N N   . THR A 1 320 ? 132.576 116.731 113.285 1 40.041  ? 758 THR A N   1 
ATOM 2426 C CA  . THR A 1 320 ? 133.483 115.686 112.83  1 40.832  ? 758 THR A CA  1 
ATOM 2427 C C   . THR A 1 320 ? 134.929 116.151 112.971 1 37.06   ? 758 THR A C   1 
ATOM 2428 O O   . THR A 1 320 ? 135.769 115.38  113.415 1 41.665  ? 758 THR A O   1 
ATOM 2429 C CB  . THR A 1 320 ? 133.208 115.303 111.376 1 43.265  ? 758 THR A CB  1 
ATOM 2430 O OG1 . THR A 1 320 ? 131.842 114.929 111.313 1 42.485  ? 758 THR A OG1 1 
ATOM 2431 C CG2 . THR A 1 320 ? 134.049 114.132 110.905 1 41.85   ? 758 THR A CG2 1 
ATOM 2432 N N   . ALA A 1 321 ? 135.22  117.373 112.535 1 36.089  ? 759 ALA A N   1 
ATOM 2433 C CA  . ALA A 1 321 ? 136.577 117.883 112.594 1 39.803  ? 759 ALA A CA  1 
ATOM 2434 C C   . ALA A 1 321 ? 137.096 117.857 114.035 1 40.77   ? 759 ALA A C   1 
ATOM 2435 O O   . ALA A 1 321 ? 138.177 117.333 114.303 1 40.519  ? 759 ALA A O   1 
ATOM 2436 C CB  . ALA A 1 321 ? 136.626 119.26  111.984 1 35.837  ? 759 ALA A CB  1 
ATOM 2437 N N   . ILE A 1 322 ? 136.317 118.405 114.974 1 40.785  ? 760 ILE A N   1 
ATOM 2438 C CA  . ILE A 1 322 ? 136.739 118.466 116.363 1 40.355  ? 760 ILE A CA  1 
ATOM 2439 C C   . ILE A 1 322 ? 136.88  117.057 116.924 1 40.115  ? 760 ILE A C   1 
ATOM 2440 O O   . ILE A 1 322 ? 137.836 116.764 117.628 1 40.774  ? 760 ILE A O   1 
ATOM 2441 C CB  . ILE A 1 322 ? 135.787 119.326 117.214 1 43.254  ? 760 ILE A CB  1 
ATOM 2442 C CG1 . ILE A 1 322 ? 135.755 120.756 116.723 1 42.328  ? 760 ILE A CG1 1 
ATOM 2443 C CG2 . ILE A 1 322 ? 136.174 119.242 118.692 1 45.495  ? 760 ILE A CG2 1 
ATOM 2444 C CD1 . ILE A 1 322 ? 134.775 121.642 117.467 1 46.514  ? 760 ILE A CD1 1 
ATOM 2445 N N   . TYR A 1 323 ? 135.93  116.182 116.597 1 37.362  ? 761 TYR A N   1 
ATOM 2446 C CA  . TYR A 1 323 ? 135.942 114.835 117.12  1 39.52   ? 761 TYR A CA  1 
ATOM 2447 C C   . TYR A 1 323 ? 137.198 114.094 116.674 1 42.223  ? 761 TYR A C   1 
ATOM 2448 O O   . TYR A 1 323 ? 137.8   113.407 117.478 1 41.488  ? 761 TYR A O   1 
ATOM 2449 C CB  . TYR A 1 323 ? 134.71  114.053 116.66  1 41.433  ? 761 TYR A CB  1 
ATOM 2450 C CG  . TYR A 1 323 ? 133.518 114.2   117.586 1 40.202  ? 761 TYR A CG  1 
ATOM 2451 C CD1 . TYR A 1 323 ? 133.29  115.365 118.312 1 40.764  ? 761 TYR A CD1 1 
ATOM 2452 C CD2 . TYR A 1 323 ? 132.633 113.152 117.736 1 42.883  ? 761 TYR A CD2 1 
ATOM 2453 C CE1 . TYR A 1 323 ? 132.208 115.477 119.165 1 43.846  ? 761 TYR A CE1 1 
ATOM 2454 C CE2 . TYR A 1 323 ? 131.557 113.244 118.595 1 43.221  ? 761 TYR A CE2 1 
ATOM 2455 C CZ  . TYR A 1 323 ? 131.34  114.41  119.299 1 43.937  ? 761 TYR A CZ  1 
ATOM 2456 O OH  . TYR A 1 323 ? 130.273 114.499 120.132 1 47.361  ? 761 TYR A OH  1 
ATOM 2457 N N   . ILE A 1 324 ? 137.573 114.21  115.398 1 40.273  ? 762 ILE A N   1 
ATOM 2458 C CA  . ILE A 1 324 ? 138.765 113.538 114.91  1 42.659  ? 762 ILE A CA  1 
ATOM 2459 C C   . ILE A 1 324 ? 139.998 114.145 115.577 1 39.97   ? 762 ILE A C   1 
ATOM 2460 O O   . ILE A 1 324 ? 140.916 113.409 115.93  1 47.104  ? 762 ILE A O   1 
ATOM 2461 C CB  . ILE A 1 324 ? 138.858 113.603 113.377 1 43.929  ? 762 ILE A CB  1 
ATOM 2462 C CG1 . ILE A 1 324 ? 137.777 112.746 112.734 1 43.68   ? 762 ILE A CG1 1 
ATOM 2463 C CG2 . ILE A 1 324 ? 140.26  113.189 112.911 1 44.75   ? 762 ILE A CG2 1 
ATOM 2464 C CD1 . ILE A 1 324 ? 137.596 112.994 111.253 1 44.075  ? 762 ILE A CD1 1 
ATOM 2465 N N   . ALA A 1 325 ? 140.022 115.472 115.738 1 38.959  ? 763 ALA A N   1 
ATOM 2466 C CA  . ALA A 1 325 ? 141.17  116.123 116.348 1 43.135  ? 763 ALA A CA  1 
ATOM 2467 C C   . ALA A 1 325 ? 141.359 115.631 117.782 1 47.407  ? 763 ALA A C   1 
ATOM 2468 O O   . ALA A 1 325 ? 142.481 115.399 118.2   1 52.93   ? 763 ALA A O   1 
ATOM 2469 C CB  . ALA A 1 325 ? 141.02  117.62  116.306 1 40.95   ? 763 ALA A CB  1 
ATOM 2470 N N   . CYS A 1 326 ? 140.263 115.466 118.528 1 48.824  ? 764 CYS A N   1 
ATOM 2471 C CA  . CYS A 1 326 ? 140.318 115.276 119.968 1 49.84   ? 764 CYS A CA  1 
ATOM 2472 C C   . CYS A 1 326 ? 140.128 113.82  120.375 1 45.687  ? 764 CYS A C   1 
ATOM 2473 O O   . CYS A 1 326 ? 139.856 113.551 121.532 1 49.399  ? 764 CYS A O   1 
ATOM 2474 C CB  . CYS A 1 326 ? 139.25  116.113 120.66  1 48.765  ? 764 CYS A CB  1 
ATOM 2475 S SG  . CYS A 1 326 ? 139.534 117.892 120.504 1 54.744  ? 764 CYS A SG  1 
ATOM 2476 N N   . GLY A 1 327 ? 140.253 112.877 119.444 1 39.743  ? 765 GLY A N   1 
ATOM 2477 C CA  . GLY A 1 327 ? 140.291 111.47  119.795 1 40.578  ? 765 GLY A CA  1 
ATOM 2478 C C   . GLY A 1 327 ? 138.921 110.902 120.126 1 44.032  ? 765 GLY A C   1 
ATOM 2479 O O   . GLY A 1 327 ? 138.81  109.844 120.729 1 40.776  ? 765 GLY A O   1 
ATOM 2480 N N   . GLN A 1 328 ? 137.864 111.597 119.708 1 43.824  ? 766 GLN A N   1 
ATOM 2481 C CA  . GLN A 1 328 ? 136.523 111.088 119.911 1 44.468  ? 766 GLN A CA  1 
ATOM 2482 C C   . GLN A 1 328 ? 136.241 110.025 118.859 1 46.921  ? 766 GLN A C   1 
ATOM 2483 O O   . GLN A 1 328 ? 136.885 109.938 117.815 1 50.287  ? 766 GLN A O   1 
ATOM 2484 C CB  . GLN A 1 328 ? 135.478 112.195 119.806 1 46.703  ? 766 GLN A CB  1 
ATOM 2485 C CG  . GLN A 1 328 ? 135.842 113.447 120.591 1 48.677  ? 766 GLN A CG  1 
ATOM 2486 C CD  . GLN A 1 328 ? 136.074 113.127 122.047 1 50.63   ? 766 GLN A CD  1 
ATOM 2487 O OE1 . GLN A 1 328 ? 135.318 112.355 122.633 1 48.133  ? 766 GLN A OE1 1 
ATOM 2488 N NE2 . GLN A 1 328 ? 137.118 113.691 122.63  1 53.029  ? 766 GLN A NE2 1 
ATOM 2489 N N   . ASP A 1 329 ? 135.249 109.208 119.151 1 51.122  ? 767 ASP A N   1 
ATOM 2490 C CA  . ASP A 1 329 ? 134.802 108.226 118.192 1 54.103  ? 767 ASP A CA  1 
ATOM 2491 C C   . ASP A 1 329 ? 134.028 108.948 117.091 1 54.242  ? 767 ASP A C   1 
ATOM 2492 O O   . ASP A 1 329 ? 132.94  109.457 117.337 1 55.985  ? 767 ASP A O   1 
ATOM 2493 C CB  . ASP A 1 329 ? 133.966 107.206 118.924 1 61.71   ? 767 ASP A CB  1 
ATOM 2494 C CG  . ASP A 1 329 ? 133.35  106.174 118.013 1 70.583  ? 767 ASP A CG  1 
ATOM 2495 O OD1 . ASP A 1 329 ? 133.874 105.982 116.892 1 77.434  ? 767 ASP A OD1 1 
ATOM 2496 O OD2 . ASP A 1 329 ? 132.346 105.607 118.448 1 77.514  ? 767 ASP A OD2 1 
ATOM 2497 N N   . ALA A 1 330 ? 134.589 109.006 115.88  1 49.903  ? 768 ALA A N   1 
ATOM 2498 C CA  . ALA A 1 330 ? 134.072 109.882 114.837 1 50.325  ? 768 ALA A CA  1 
ATOM 2499 C C   . ALA A 1 330 ? 132.7   109.422 114.325 1 45.026  ? 768 ALA A C   1 
ATOM 2500 O O   . ALA A 1 330 ? 131.877 110.247 113.947 1 44.042  ? 768 ALA A O   1 
ATOM 2501 C CB  . ALA A 1 330 ? 135.057 109.977 113.702 1 53.387  ? 768 ALA A CB  1 
ATOM 2502 N N   . ALA A 1 331 ? 132.431 108.119 114.351 1 42.771  ? 769 ALA A N   1 
ATOM 2503 C CA  . ALA A 1 331 ? 131.117 107.614 113.976 1 45.686  ? 769 ALA A CA  1 
ATOM 2504 C C   . ALA A 1 331 ? 130.009 108.294 114.791 1 47.926  ? 769 ALA A C   1 
ATOM 2505 O O   . ALA A 1 331 ? 128.915 108.527 114.284 1 49.409  ? 769 ALA A O   1 
ATOM 2506 C CB  . ALA A 1 331 ? 131.077 106.124 114.135 1 42.529  ? 769 ALA A CB  1 
ATOM 2507 N N   . GLN A 1 332 ? 130.308 108.666 116.039 1 48.57   ? 770 GLN A N   1 
ATOM 2508 C CA  . GLN A 1 332 ? 129.301 109.217 116.929 1 51.711  ? 770 GLN A CA  1 
ATOM 2509 C C   . GLN A 1 332 ? 128.798 110.558 116.421 1 50.149  ? 770 GLN A C   1 
ATOM 2510 O O   . GLN A 1 332 ? 127.761 111.039 116.865 1 50.933  ? 770 GLN A O   1 
ATOM 2511 C CB  . GLN A 1 332 ? 129.802 109.297 118.368 1 60.242  ? 770 GLN A CB  1 
ATOM 2512 C CG  . GLN A 1 332 ? 130.124 107.917 118.927 1 71.233  ? 770 GLN A CG  1 
ATOM 2513 C CD  . GLN A 1 332 ? 129.98  107.827 120.424 1 80.713  ? 770 GLN A CD  1 
ATOM 2514 O OE1 . GLN A 1 332 ? 129.13  107.096 120.941 1 84.306  ? 770 GLN A OE1 1 
ATOM 2515 N NE2 . GLN A 1 332 ? 130.828 108.553 121.136 1 86.52   ? 770 GLN A NE2 1 
ATOM 2516 N N   . ASN A 1 333 ? 129.497 111.146 115.453 1 47.687  ? 771 ASN A N   1 
ATOM 2517 C CA  . ASN A 1 333 ? 129.01  112.383 114.875 1 48.116  ? 771 ASN A CA  1 
ATOM 2518 C C   . ASN A 1 333 ? 127.594 112.196 114.333 1 47.728  ? 771 ASN A C   1 
ATOM 2519 O O   . ASN A 1 333 ? 126.788 113.119 114.373 1 44.393  ? 771 ASN A O   1 
ATOM 2520 C CB  . ASN A 1 333 ? 129.953 112.887 113.801 1 54.501  ? 771 ASN A CB  1 
ATOM 2521 C CG  . ASN A 1 333 ? 129.858 112.101 112.521 1 59.92   ? 771 ASN A CG  1 
ATOM 2522 O OD1 . ASN A 1 333 ? 129.731 110.873 112.535 1 64.712  ? 771 ASN A OD1 1 
ATOM 2523 N ND2 . ASN A 1 333 ? 129.928 112.798 111.4   1 70.278  ? 771 ASN A ND2 1 
ATOM 2524 N N   . VAL A 1 334 ? 127.291 110.988 113.862 1 45.165  ? 772 VAL A N   1 
ATOM 2525 C CA  . VAL A 1 334 ? 125.958 110.67  113.388 1 52.822  ? 772 VAL A CA  1 
ATOM 2526 C C   . VAL A 1 334 ? 124.919 111.185 114.381 1 57.552  ? 772 VAL A C   1 
ATOM 2527 O O   . VAL A 1 334 ? 124.007 111.921 114.012 1 71.622  ? 772 VAL A O   1 
ATOM 2528 C CB  . VAL A 1 334 ? 125.807 109.164 113.123 1 55.957  ? 772 VAL A CB  1 
ATOM 2529 C CG1 . VAL A 1 334 ? 124.36  108.725 113.202 1 59.82   ? 772 VAL A CG1 1 
ATOM 2530 C CG2 . VAL A 1 334 ? 126.389 108.765 111.777 1 58.732  ? 772 VAL A CG2 1 
ATOM 2531 N N   . GLY A 1 335 ? 125.055 110.818 115.648 1 55.106  ? 773 GLY A N   1 
ATOM 2532 C CA  . GLY A 1 335 ? 124.128 111.328 116.645 1 54.382  ? 773 GLY A CA  1 
ATOM 2533 C C   . GLY A 1 335 ? 124.501 112.713 117.171 1 50.979  ? 773 GLY A C   1 
ATOM 2534 O O   . GLY A 1 335 ? 123.626 113.489 117.537 1 50.336  ? 773 GLY A O   1 
ATOM 2535 N N   . SER A 1 336 ? 125.792 113.044 117.209 1 47.003  ? 774 SER A N   1 
ATOM 2536 C CA  . SER A 1 336 ? 126.219 114.22  117.945 1 43.14   ? 774 SER A CA  1 
ATOM 2537 C C   . SER A 1 336 ? 125.979 115.5   117.159 1 40.602  ? 774 SER A C   1 
ATOM 2538 O O   . SER A 1 336 ? 126.007 116.573 117.745 1 42.357  ? 774 SER A O   1 
ATOM 2539 C CB  . SER A 1 336 ? 127.668 114.122 118.331 1 42.157  ? 774 SER A CB  1 
ATOM 2540 O OG  . SER A 1 336 ? 127.898 112.988 119.152 1 43.344  ? 774 SER A OG  1 
ATOM 2541 N N   . SER A 1 337 ? 125.772 115.396 115.844 1 39.03   ? 775 SER A N   1 
ATOM 2542 C CA  . SER A 1 337 ? 125.627 116.584 115.026 1 42.322  ? 775 SER A CA  1 
ATOM 2543 C C   . SER A 1 337 ? 124.195 117.12  115.043 1 40.637  ? 775 SER A C   1 
ATOM 2544 O O   . SER A 1 337 ? 123.939 118.153 114.434 1 39.149  ? 775 SER A O   1 
ATOM 2545 C CB  . SER A 1 337 ? 126.098 116.314 113.632 1 41.36   ? 775 SER A CB  1 
ATOM 2546 O OG  . SER A 1 337 ? 125.724 115.012 113.195 1 46.708  ? 775 SER A OG  1 
ATOM 2547 N N   . ASN A 1 338 ? 123.26  116.42  115.69  1 38.004  ? 776 ASN A N   1 
ATOM 2548 C CA  . ASN A 1 338 ? 121.898 116.916 115.816 1 39.096  ? 776 ASN A CA  1 
ATOM 2549 C C   . ASN A 1 338 ? 121.931 118.323 116.382 1 38.447  ? 776 ASN A C   1 
ATOM 2550 O O   . ASN A 1 338 ? 122.48  118.567 117.452 1 41.211  ? 776 ASN A O   1 
ATOM 2551 C CB  . ASN A 1 338 ? 121.033 116.055 116.732 1 41.591  ? 776 ASN A CB  1 
ATOM 2552 C CG  . ASN A 1 338 ? 120.644 114.737 116.114 1 44.529  ? 776 ASN A CG  1 
ATOM 2553 O OD1 . ASN A 1 338 ? 120.834 114.522 114.911 1 46.887  ? 776 ASN A OD1 1 
ATOM 2554 N ND2 . ASN A 1 338 ? 120.127 113.836 116.936 1 50.248  ? 776 ASN A ND2 1 
ATOM 2555 N N   . CYS A 1 339 ? 121.337 119.258 115.651 1 36.507  ? 777 CYS A N   1 
ATOM 2556 C CA  . CYS A 1 339 ? 121.409 120.642 116.059 1 38.671  ? 777 CYS A CA  1 
ATOM 2557 C C   . CYS A 1 339 ? 120.279 121.416 115.408 1 37.994  ? 777 CYS A C   1 
ATOM 2558 O O   . CYS A 1 339 ? 119.884 121.107 114.291 1 40.9    ? 777 CYS A O   1 
ATOM 2559 C CB  . CYS A 1 339 ? 122.751 121.241 115.655 1 38.415  ? 777 CYS A CB  1 
ATOM 2560 S SG  . CYS A 1 339 ? 122.851 123.029 115.835 1 44.129  ? 777 CYS A SG  1 
ATOM 2561 N N   . ILE A 1 340 ? 119.787 122.418 116.129 1 36.978  ? 778 ILE A N   1 
ATOM 2562 C CA  . ILE A 1 340 ? 118.87  123.379 115.557 1 39.18   ? 778 ILE A CA  1 
ATOM 2563 C C   . ILE A 1 340 ? 119.468 124.755 115.748 1 37.368  ? 778 ILE A C   1 
ATOM 2564 O O   . ILE A 1 340 ? 119.893 125.092 116.844 1 39.119  ? 778 ILE A O   1 
ATOM 2565 C CB  . ILE A 1 340 ? 117.451 123.303 116.152 1 42.762  ? 778 ILE A CB  1 
ATOM 2566 C CG1 . ILE A 1 340 ? 116.569 124.38  115.527 1 42.019  ? 778 ILE A CG1 1 
ATOM 2567 C CG2 . ILE A 1 340 ? 117.454 123.409 117.682 1 45.819  ? 778 ILE A CG2 1 
ATOM 2568 C CD1 . ILE A 1 340 ? 115.082 124.093 115.607 1 44.394  ? 778 ILE A CD1 1 
ATOM 2569 N N   . THR A 1 341 ? 119.523 125.505 114.644 1 37.927  ? 779 THR A N   1 
ATOM 2570 C CA  . THR A 1 341 ? 120.101 126.831 114.621 1 40.065  ? 779 THR A CA  1 
ATOM 2571 C C   . THR A 1 341 ? 118.959 127.826 114.455 1 40.191  ? 779 THR A C   1 
ATOM 2572 O O   . THR A 1 341 ? 118.174 127.7   113.524 1 43.085  ? 779 THR A O   1 
ATOM 2573 C CB  . THR A 1 341 ? 121.095 126.962 113.464 1 44.3    ? 779 THR A CB  1 
ATOM 2574 O OG1 . THR A 1 341 ? 122.131 126     113.628 1 48.512  ? 779 THR A OG1 1 
ATOM 2575 C CG2 . THR A 1 341 ? 121.698 128.351 113.4   1 47.258  ? 779 THR A CG2 1 
ATOM 2576 N N   . LEU A 1 342 ? 118.893 128.819 115.344 1 40.338  ? 780 LEU A N   1 
ATOM 2577 C CA  . LEU A 1 342 ? 117.856 129.829 115.292 1 41.304  ? 780 LEU A CA  1 
ATOM 2578 C C   . LEU A 1 342 ? 118.511 131.198 115.243 1 42.779  ? 780 LEU A C   1 
ATOM 2579 O O   . LEU A 1 342 ? 119.48  131.452 115.957 1 46.347  ? 780 LEU A O   1 
ATOM 2580 C CB  . LEU A 1 342 ? 116.939 129.706 116.508 1 42.412  ? 780 LEU A CB  1 
ATOM 2581 C CG  . LEU A 1 342 ? 116.196 128.378 116.643 1 44.608  ? 780 LEU A CG  1 
ATOM 2582 C CD1 . LEU A 1 342 ? 115.381 128.372 117.92  1 48.133  ? 780 LEU A CD1 1 
ATOM 2583 C CD2 . LEU A 1 342 ? 115.316 128.111 115.424 1 45.023  ? 780 LEU A CD2 1 
ATOM 2584 N N   . MET A 1 343 ? 117.953 132.067 114.401 1 42.767  ? 781 MET A N   1 
ATOM 2585 C CA  . MET A 1 343 ? 118.409 133.436 114.301 1 45.848  ? 781 MET A CA  1 
ATOM 2586 C C   . MET A 1 343 ? 117.212 134.367 114.419 1 45.041  ? 781 MET A C   1 
ATOM 2587 O O   . MET A 1 343 ? 116.161 134.099 113.847 1 50.762  ? 781 MET A O   1 
ATOM 2588 C CB  . MET A 1 343 ? 119.118 133.671 112.968 1 49.652  ? 781 MET A CB  1 
ATOM 2589 C CG  . MET A 1 343 ? 120.233 132.688 112.707 1 53.291  ? 781 MET A CG  1 
ATOM 2590 S SD  . MET A 1 343 ? 121.183 133.168 111.256 1 54.813  ? 781 MET A SD  1 
ATOM 2591 C CE  . MET A 1 343 ? 122.247 131.729 111.098 1 57.507  ? 781 MET A CE  1 
ATOM 2592 N N   . GLU A 1 344 ? 117.393 135.471 115.144 1 46.87   ? 782 GLU A N   1 
ATOM 2593 C CA  . GLU A 1 344 ? 116.342 136.459 115.305 1 49.953  ? 782 GLU A CA  1 
ATOM 2594 C C   . GLU A 1 344 ? 116.957 137.85  115.296 1 47.872  ? 782 GLU A C   1 
ATOM 2595 O O   . GLU A 1 344 ? 118.17  137.997 115.397 1 51.868  ? 782 GLU A O   1 
ATOM 2596 C CB  . GLU A 1 344 ? 115.588 136.28  116.622 1 54.437  ? 782 GLU A CB  1 
ATOM 2597 C CG  . GLU A 1 344 ? 115.224 134.836 116.943 1 62.934  ? 782 GLU A CG  1 
ATOM 2598 C CD  . GLU A 1 344 ? 114.613 134.661 118.324 1 72.128  ? 782 GLU A CD  1 
ATOM 2599 O OE1 . GLU A 1 344 ? 114.357 135.679 119.006 1 73.151  ? 782 GLU A OE1 1 
ATOM 2600 O OE2 . GLU A 1 344 ? 114.41  133.492 118.721 1 71.809  ? 782 GLU A OE2 1 
ATOM 2601 N N   . ALA A 1 345 ? 116.097 138.86  115.139 1 49.858  ? 783 ALA A N   1 
ATOM 2602 C CA  . ALA A 1 345 ? 116.499 140.243 115.304 1 54.471  ? 783 ALA A CA  1 
ATOM 2603 C C   . ALA A 1 345 ? 116.537 140.561 116.792 1 54.13   ? 783 ALA A C   1 
ATOM 2604 O O   . ALA A 1 345 ? 115.785 139.988 117.574 1 59.684  ? 783 ALA A O   1 
ATOM 2605 C CB  . ALA A 1 345 ? 115.557 141.167 114.569 1 55.758  ? 783 ALA A CB  1 
ATOM 2606 N N   . SER A 1 346 ? 117.412 141.49  117.171 1 55.873  ? 784 SER A N   1 
ATOM 2607 C CA  . SER A 1 346 ? 117.553 141.853 118.566 1 57.926  ? 784 SER A CA  1 
ATOM 2608 C C   . SER A 1 346 ? 118.167 143.241 118.664 1 57.54   ? 784 SER A C   1 
ATOM 2609 O O   . SER A 1 346 ? 118.623 143.799 117.666 1 57.351  ? 784 SER A O   1 
ATOM 2610 C CB  . SER A 1 346 ? 118.371 140.826 119.318 1 63.582  ? 784 SER A CB  1 
ATOM 2611 O OG  . SER A 1 346 ? 119.753 141.141 119.287 1 66.269  ? 784 SER A OG  1 
ATOM 2612 N N   . GLY A 1 347 ? 118.175 143.772 119.888 1 62.944  ? 785 GLY A N   1 
ATOM 2613 C CA  . GLY A 1 347 ? 118.681 145.106 120.15  1 67.779  ? 785 GLY A CA  1 
ATOM 2614 C C   . GLY A 1 347 ? 117.546 146.12  120.209 1 75.307  ? 785 GLY A C   1 
ATOM 2615 O O   . GLY A 1 347 ? 116.399 145.801 119.904 1 72.849  ? 785 GLY A O   1 
ATOM 2616 N N   . PRO A 1 348 ? 117.838 147.381 120.597 1 84.574  ? 786 PRO A N   1 
ATOM 2617 C CA  . PRO A 1 348 ? 116.813 148.416 120.658 1 88.508  ? 786 PRO A CA  1 
ATOM 2618 C C   . PRO A 1 348 ? 116.208 148.782 119.303 1 90.36   ? 786 PRO A C   1 
ATOM 2619 O O   . PRO A 1 348 ? 115.209 149.495 119.254 1 98.197  ? 786 PRO A O   1 
ATOM 2620 C CB  . PRO A 1 348 ? 117.553 149.599 121.276 1 91.5    ? 786 PRO A CB  1 
ATOM 2621 C CG  . PRO A 1 348 ? 118.996 149.349 120.877 1 91.927  ? 786 PRO A CG  1 
ATOM 2622 C CD  . PRO A 1 348 ? 119.166 147.869 120.998 1 88.448  ? 786 PRO A CD  1 
ATOM 2623 N N   . THR A 1 349 ? 116.818 148.31  118.206 1 87.41   ? 787 THR A N   1 
ATOM 2624 C CA  . THR A 1 349 ? 116.383 148.683 116.864 1 86.271  ? 787 THR A CA  1 
ATOM 2625 C C   . THR A 1 349 ? 116.05  147.453 116.011 1 80.999  ? 787 THR A C   1 
ATOM 2626 O O   . THR A 1 349 ? 115.677 147.593 114.848 1 78.514  ? 787 THR A O   1 
ATOM 2627 C CB  . THR A 1 349 ? 117.478 149.55  116.232 1 92.915  ? 787 THR A CB  1 
ATOM 2628 O OG1 . THR A 1 349 ? 117.359 150.871 116.757 1 97.082  ? 787 THR A OG1 1 
ATOM 2629 C CG2 . THR A 1 349 ? 117.366 149.659 114.722 1 97.196  ? 787 THR A CG2 1 
ATOM 2630 N N   . ASN A 1 350 ? 116.157 146.245 116.58  1 77.105  ? 788 ASN A N   1 
ATOM 2631 C CA  . ASN A 1 350 ? 115.954 145.009 115.833 1 75.703  ? 788 ASN A CA  1 
ATOM 2632 C C   . ASN A 1 350 ? 116.959 144.902 114.69  1 70.527  ? 788 ASN A C   1 
ATOM 2633 O O   . ASN A 1 350 ? 116.669 144.288 113.669 1 72.369  ? 788 ASN A O   1 
ATOM 2634 C CB  . ASN A 1 350 ? 114.53  144.869 115.3   1 80.615  ? 788 ASN A CB  1 
ATOM 2635 C CG  . ASN A 1 350 ? 113.56  144.438 116.372 1 86.491  ? 788 ASN A CG  1 
ATOM 2636 O OD1 . ASN A 1 350 ? 112.879 145.285 116.961 1 96.289  ? 788 ASN A OD1 1 
ATOM 2637 N ND2 . ASN A 1 350 ? 113.504 143.145 116.661 1 88.681  ? 788 ASN A ND2 1 
ATOM 2638 N N   . GLU A 1 351 ? 118.15  145.478 114.881 1 67.849  ? 789 GLU A N   1 
ATOM 2639 C CA  . GLU A 1 351 ? 119.17  145.479 113.847 1 68.841  ? 789 GLU A CA  1 
ATOM 2640 C C   . GLU A 1 351 ? 120.257 144.442 114.124 1 61.721  ? 789 GLU A C   1 
ATOM 2641 O O   . GLU A 1 351 ? 120.956 144.047 113.198 1 61.74   ? 789 GLU A O   1 
ATOM 2642 C CB  . GLU A 1 351 ? 119.789 146.867 113.702 1 80.687  ? 789 GLU A CB  1 
ATOM 2643 C CG  . GLU A 1 351 ? 119.365 147.597 112.432 1 93.293  ? 789 GLU A CG  1 
ATOM 2644 C CD  . GLU A 1 351 ? 120.313 148.724 112.044 1 107.318 ? 789 GLU A CD  1 
ATOM 2645 O OE1 . GLU A 1 351 ? 120.777 148.737 110.88  1 108.852 ? 789 GLU A OE1 1 
ATOM 2646 O OE2 . GLU A 1 351 ? 120.612 149.577 112.912 1 110.35  ? 789 GLU A OE2 1 
ATOM 2647 N N   . ASP A 1 352 ? 120.414 144.008 115.38  1 59.352  ? 790 ASP A N   1 
ATOM 2648 C CA  . ASP A 1 352 ? 121.465 143.069 115.736 1 56.396  ? 790 ASP A CA  1 
ATOM 2649 C C   . ASP A 1 352 ? 120.977 141.64  115.548 1 52.765  ? 790 ASP A C   1 
ATOM 2650 O O   . ASP A 1 352 ? 119.783 141.373 115.596 1 52.792  ? 790 ASP A O   1 
ATOM 2651 C CB  . ASP A 1 352 ? 121.943 143.296 117.156 1 57.488  ? 790 ASP A CB  1 
ATOM 2652 C CG  . ASP A 1 352 ? 122.158 144.76  117.493 1 63.092  ? 790 ASP A CG  1 
ATOM 2653 O OD1 . ASP A 1 352 ? 122.74  145.471 116.65  1 64.957  ? 790 ASP A OD1 1 
ATOM 2654 O OD2 . ASP A 1 352 ? 121.737 145.174 118.589 1 70.21   ? 790 ASP A OD2 1 
ATOM 2655 N N   . LEU A 1 353 ? 121.92  140.721 115.354 1 48.997  ? 791 LEU A N   1 
ATOM 2656 C CA  . LEU A 1 353 ? 121.588 139.346 115.047 1 47.108  ? 791 LEU A CA  1 
ATOM 2657 C C   . LEU A 1 353 ? 121.78  138.493 116.291 1 50.362  ? 791 LEU A C   1 
ATOM 2658 O O   . LEU A 1 353 ? 122.903 138.265 116.718 1 52.492  ? 791 LEU A O   1 
ATOM 2659 C CB  . LEU A 1 353 ? 122.477 138.828 113.923 1 47.489  ? 791 LEU A CB  1 
ATOM 2660 C CG  . LEU A 1 353 ? 122.254 137.366 113.542 1 50.273  ? 791 LEU A CG  1 
ATOM 2661 C CD1 . LEU A 1 353 ? 120.896 137.193 112.886 1 52.993  ? 791 LEU A CD1 1 
ATOM 2662 C CD2 . LEU A 1 353 ? 123.358 136.899 112.637 1 51.672  ? 791 LEU A CD2 1 
ATOM 2663 N N   . TYR A 1 354 ? 120.68  137.986 116.835 1 46.308  ? 792 TYR A N   1 
ATOM 2664 C CA  . TYR A 1 354 ? 120.755 136.977 117.868 1 46.965  ? 792 TYR A CA  1 
ATOM 2665 C C   . TYR A 1 354 ? 120.82  135.609 117.21  1 44.582  ? 792 TYR A C   1 
ATOM 2666 O O   . TYR A 1 354 ? 120.038 135.321 116.311 1 47.753  ? 792 TYR A O   1 
ATOM 2667 C CB  . TYR A 1 354 ? 119.54  137.081 118.786 1 49.817  ? 792 TYR A CB  1 
ATOM 2668 C CG  . TYR A 1 354 ? 119.406 135.891 119.714 1 53.583  ? 792 TYR A CG  1 
ATOM 2669 C CD1 . TYR A 1 354 ? 120.063 135.865 120.933 1 55.431  ? 792 TYR A CD1 1 
ATOM 2670 C CD2 . TYR A 1 354 ? 118.648 134.788 119.354 1 54.422  ? 792 TYR A CD2 1 
ATOM 2671 C CE1 . TYR A 1 354 ? 119.945 134.781 121.782 1 57.765  ? 792 TYR A CE1 1 
ATOM 2672 C CE2 . TYR A 1 354 ? 118.522 133.697 120.194 1 56.443  ? 792 TYR A CE2 1 
ATOM 2673 C CZ  . TYR A 1 354 ? 119.176 133.693 121.412 1 56.388  ? 792 TYR A CZ  1 
ATOM 2674 O OH  . TYR A 1 354 ? 119.063 132.618 122.244 1 57.116  ? 792 TYR A OH  1 
ATOM 2675 N N   . ILE A 1 355 ? 121.769 134.783 117.649 1 41.166  ? 793 ILE A N   1 
ATOM 2676 C CA  . ILE A 1 355 ? 121.906 133.439 117.12  1 40.436  ? 793 ILE A CA  1 
ATOM 2677 C C   . ILE A 1 355 ? 122.008 132.49  118.298 1 42.433  ? 793 ILE A C   1 
ATOM 2678 O O   . ILE A 1 355 ? 122.554 132.837 119.338 1 45.022  ? 793 ILE A O   1 
ATOM 2679 C CB  . ILE A 1 355 ? 123.116 133.276 116.178 1 44.14   ? 793 ILE A CB  1 
ATOM 2680 C CG1 . ILE A 1 355 ? 123.201 131.851 115.648 1 43.765  ? 793 ILE A CG1 1 
ATOM 2681 C CG2 . ILE A 1 355 ? 124.421 133.698 116.855 1 43.064  ? 793 ILE A CG2 1 
ATOM 2682 C CD1 . ILE A 1 355 ? 124.202 131.649 114.529 1 46.024  ? 793 ILE A CD1 1 
ATOM 2683 N N   . SER A 1 356 ? 121.451 131.299 118.11  1 42.322  ? 794 SER A N   1 
ATOM 2684 C CA  . SER A 1 356 ? 121.568 130.251 119.096 1 45.258  ? 794 SER A CA  1 
ATOM 2685 C C   . SER A 1 356 ? 121.638 128.911 118.39  1 43.551  ? 794 SER A C   1 
ATOM 2686 O O   . SER A 1 356 ? 121.018 128.706 117.352 1 45.57   ? 794 SER A O   1 
ATOM 2687 C CB  . SER A 1 356 ? 120.445 130.279 120.101 1 48.184  ? 794 SER A CB  1 
ATOM 2688 O OG  . SER A 1 356 ? 119.219 129.948 119.473 1 54.462  ? 794 SER A OG  1 
ATOM 2689 N N   . CYS A 1 357 ? 122.44  128.022 118.965 1 41.946  ? 795 CYS A N   1 
ATOM 2690 C CA  . CYS A 1 357 ? 122.513 126.649 118.526 1 41.944  ? 795 CYS A CA  1 
ATOM 2691 C C   . CYS A 1 357 ? 122.11  125.77  119.7   1 40.173  ? 795 CYS A C   1 
ATOM 2692 O O   . CYS A 1 357 ? 122.545 125.996 120.818 1 39.198  ? 795 CYS A O   1 
ATOM 2693 C CB  . CYS A 1 357 ? 123.909 126.318 117.999 1 52.299  ? 795 CYS A CB  1 
ATOM 2694 S SG  . CYS A 1 357 ? 124.169 126.861 116.288 1 59.432  ? 795 CYS A SG  1 
ATOM 2695 N N   . THR A 1 358 ? 121.283 124.76  119.425 1 39.055  ? 796 THR A N   1 
ATOM 2696 C CA  . THR A 1 358 ? 120.898 123.801 120.443 1 38.202  ? 796 THR A CA  1 
ATOM 2697 C C   . THR A 1 358 ? 121.228 122.411 119.936 1 37.382  ? 796 THR A C   1 
ATOM 2698 O O   . THR A 1 358 ? 120.823 122.036 118.834 1 39.205  ? 796 THR A O   1 
ATOM 2699 C CB  . THR A 1 358 ? 119.414 123.899 120.789 1 41.922  ? 796 THR A CB  1 
ATOM 2700 O OG1 . THR A 1 358 ? 119.082 125.26  121.015 1 37.086  ? 796 THR A OG1 1 
ATOM 2701 C CG2 . THR A 1 358 ? 119.078 123.105 122.038 1 44.768  ? 796 THR A CG2 1 
ATOM 2702 N N   . MET A 1 359 ? 122.006 121.686 120.743 1 36.944  ? 797 MET A N   1 
ATOM 2703 C CA  . MET A 1 359 ? 122.498 120.378 120.379 1 38.777  ? 797 MET A CA  1 
ATOM 2704 C C   . MET A 1 359 ? 122.196 119.442 121.532 1 38.826  ? 797 MET A C   1 
ATOM 2705 O O   . MET A 1 359 ? 122.911 119.44  122.528 1 41.885  ? 797 MET A O   1 
ATOM 2706 C CB  . MET A 1 359 ? 124.008 120.419 120.121 1 39.356  ? 797 MET A CB  1 
ATOM 2707 C CG  . MET A 1 359 ? 124.41  121.536 119.177 1 44.215  ? 797 MET A CG  1 
ATOM 2708 S SD  . MET A 1 359 ? 126.064 121.387 118.48  1 45.942  ? 797 MET A SD  1 
ATOM 2709 C CE  . MET A 1 359 ? 126.044 119.775 117.704 1 43.824  ? 797 MET A CE  1 
ATOM 2710 N N   . PRO A 1 360 ? 121.125 118.636 121.457 1 41.285  ? 798 PRO A N   1 
ATOM 2711 C CA  . PRO A 1 360 ? 120.716 117.835 122.598 1 41.227  ? 798 PRO A CA  1 
ATOM 2712 C C   . PRO A 1 360 ? 121.453 116.525 122.812 1 39.853  ? 798 PRO A C   1 
ATOM 2713 O O   . PRO A 1 360 ? 121.243 115.917 123.855 1 43.362  ? 798 PRO A O   1 
ATOM 2714 C CB  . PRO A 1 360 ? 119.25  117.557 122.321 1 44.798  ? 798 PRO A CB  1 
ATOM 2715 C CG  . PRO A 1 360 ? 119.191 117.528 120.825 1 48.65   ? 798 PRO A CG  1 
ATOM 2716 C CD  . PRO A 1 360 ? 120.194 118.536 120.326 1 44.343  ? 798 PRO A CD  1 
ATOM 2717 N N   . SER A 1 361 ? 122.286 116.079 121.866 1 37.804  ? 799 SER A N   1 
ATOM 2718 C CA  . SER A 1 361 ? 122.848 114.741 121.953 1 38.933  ? 799 SER A CA  1 
ATOM 2719 C C   . SER A 1 361 ? 124.344 114.726 121.64  1 39.464  ? 799 SER A C   1 
ATOM 2720 O O   . SER A 1 361 ? 124.793 113.905 120.847 1 39.525  ? 799 SER A O   1 
ATOM 2721 C CB  . SER A 1 361 ? 122.097 113.782 121.06  1 41.069  ? 799 SER A CB  1 
ATOM 2722 O OG  . SER A 1 361 ? 121.74  114.398 119.83  1 44.418  ? 799 SER A OG  1 
ATOM 2723 N N   . ILE A 1 362 ? 125.122 115.603 122.28  1 43.249  ? 800 ILE A N   1 
ATOM 2724 C CA  . ILE A 1 362 ? 126.568 115.587 122.102 1 44.815  ? 800 ILE A CA  1 
ATOM 2725 C C   . ILE A 1 362 ? 127.178 114.443 122.911 1 44.705  ? 800 ILE A C   1 
ATOM 2726 O O   . ILE A 1 362 ? 127.257 114.526 124.126 1 47.603  ? 800 ILE A O   1 
ATOM 2727 C CB  . ILE A 1 362 ? 127.179 116.943 122.474 1 45.164  ? 800 ILE A CB  1 
ATOM 2728 C CG1 . ILE A 1 362 ? 126.662 118.034 121.542 1 44.602  ? 800 ILE A CG1 1 
ATOM 2729 C CG2 . ILE A 1 362 ? 128.71  116.865 122.485 1 45.129  ? 800 ILE A CG2 1 
ATOM 2730 C CD1 . ILE A 1 362 ? 127.28  119.393 121.773 1 44.857  ? 800 ILE A CD1 1 
ATOM 2731 N N   . GLU A 1 363 ? 127.618 113.388 122.216 1 48.362  ? 801 GLU A N   1 
ATOM 2732 C CA  . GLU A 1 363 ? 128.282 112.247 122.83  1 48.941  ? 801 GLU A CA  1 
ATOM 2733 C C   . GLU A 1 363 ? 129.787 112.492 122.796 1 49.856  ? 801 GLU A C   1 
ATOM 2734 O O   . GLU A 1 363 ? 130.376 112.573 121.718 1 52.818  ? 801 GLU A O   1 
ATOM 2735 C CB  . GLU A 1 363 ? 127.962 110.966 122.063 1 54.397  ? 801 GLU A CB  1 
ATOM 2736 C CG  . GLU A 1 363 ? 126.463 110.729 121.893 1 65.079  ? 801 GLU A CG  1 
ATOM 2737 C CD  . GLU A 1 363 ? 125.989 110.596 120.446 1 77.067  ? 801 GLU A CD  1 
ATOM 2738 O OE1 . GLU A 1 363 ? 124.79  110.899 120.202 1 82.812  ? 801 GLU A OE1 1 
ATOM 2739 O OE2 . GLU A 1 363 ? 126.801 110.211 119.561 1 75.775  ? 801 GLU A OE2 1 
ATOM 2740 N N   . ILE A 1 364 ? 130.401 112.616 123.974 1 47.986  ? 802 ILE A N   1 
ATOM 2741 C CA  . ILE A 1 364 ? 131.767 113.091 124.047 1 50.267  ? 802 ILE A CA  1 
ATOM 2742 C C   . ILE A 1 364 ? 132.382 112.716 125.393 1 51.384  ? 802 ILE A C   1 
ATOM 2743 O O   . ILE A 1 364 ? 131.684 112.574 126.391 1 51.305  ? 802 ILE A O   1 
ATOM 2744 C CB  . ILE A 1 364 ? 131.804 114.604 123.782 1 52.795  ? 802 ILE A CB  1 
ATOM 2745 C CG1 . ILE A 1 364 ? 133.066 115.029 123.075 1 54.065  ? 802 ILE A CG1 1 
ATOM 2746 C CG2 . ILE A 1 364 ? 131.583 115.388 125.067 1 54.366  ? 802 ILE A CG2 1 
ATOM 2747 C CD1 . ILE A 1 364 ? 133.007 116.438 122.541 1 56.383  ? 802 ILE A CD1 1 
ATOM 2748 N N   . GLY A 1 365 ? 133.705 112.558 125.388 1 51.833  ? 803 GLY A N   1 
ATOM 2749 C CA  . GLY A 1 365 ? 134.482 112.212 126.567 1 52.415  ? 803 GLY A CA  1 
ATOM 2750 C C   . GLY A 1 365 ? 135.91  112.729 126.431 1 52.413  ? 803 GLY A C   1 
ATOM 2751 O O   . GLY A 1 365 ? 136.314 113.144 125.349 1 53.429  ? 803 GLY A O   1 
ATOM 2752 N N   . THR A 1 366 ? 136.654 112.739 127.545 1 51.693  ? 804 THR A N   1 
ATOM 2753 C CA  . THR A 1 366 ? 138.045 113.171 127.545 1 51.204  ? 804 THR A CA  1 
ATOM 2754 C C   . THR A 1 366 ? 138.942 112.132 128.206 1 46.493  ? 804 THR A C   1 
ATOM 2755 O O   . THR A 1 366 ? 140.089 112.418 128.5   1 51.352  ? 804 THR A O   1 
ATOM 2756 C CB  . THR A 1 366 ? 138.171 114.519 128.241 1 52.03   ? 804 THR A CB  1 
ATOM 2757 O OG1 . THR A 1 366 ? 137.803 114.36  129.608 1 53.426  ? 804 THR A OG1 1 
ATOM 2758 C CG2 . THR A 1 366 ? 137.342 115.585 127.556 1 54.085  ? 804 THR A CG2 1 
ATOM 2759 N N   . VAL A 1 367 ? 138.424 110.921 128.398 1 48.853  ? 805 VAL A N   1 
ATOM 2760 C CA  . VAL A 1 367 ? 139.181 109.821 128.958 1 50.982  ? 805 VAL A CA  1 
ATOM 2761 C C   . VAL A 1 367 ? 138.747 108.564 128.223 1 49.944  ? 805 VAL A C   1 
ATOM 2762 O O   . VAL A 1 367 ? 137.579 108.404 127.896 1 52.443  ? 805 VAL A O   1 
ATOM 2763 C CB  . VAL A 1 367 ? 138.936 109.679 130.47  1 56.046  ? 805 VAL A CB  1 
ATOM 2764 C CG1 . VAL A 1 367 ? 139.498 108.377 131.023 1 60.408  ? 805 VAL A CG1 1 
ATOM 2765 C CG2 . VAL A 1 367 ? 139.503 110.853 131.231 1 58.938  ? 805 VAL A CG2 1 
ATOM 2766 N N   . GLY A 1 368 ? 139.697 107.671 127.985 1 49.115  ? 806 GLY A N   1 
ATOM 2767 C CA  . GLY A 1 368 ? 139.385 106.393 127.379 1 52.038  ? 806 GLY A CA  1 
ATOM 2768 C C   . GLY A 1 368 ? 139.297 106.491 125.862 1 55.187  ? 806 GLY A C   1 
ATOM 2769 O O   . GLY A 1 368 ? 139.169 107.575 125.293 1 55.952  ? 806 GLY A O   1 
ATOM 2770 N N   . GLY A 1 369 ? 139.394 105.328 125.218 1 58.497  ? 807 GLY A N   1 
ATOM 2771 C CA  . GLY A 1 369 ? 139.371 105.242 123.769 1 58.108  ? 807 GLY A CA  1 
ATOM 2772 C C   . GLY A 1 369 ? 140.487 106.073 123.135 1 58.189  ? 807 GLY A C   1 
ATOM 2773 O O   . GLY A 1 369 ? 141.614 106.119 123.629 1 57.211  ? 807 GLY A O   1 
ATOM 2774 N N   . GLY A 1 370 ? 140.13  106.751 122.042 1 52.019  ? 808 GLY A N   1 
ATOM 2775 C CA  . GLY A 1 370 ? 141.063 107.535 121.258 1 50.086  ? 808 GLY A CA  1 
ATOM 2776 C C   . GLY A 1 370 ? 141.755 108.62  122.073 1 50.034  ? 808 GLY A C   1 
ATOM 2777 O O   . GLY A 1 370 ? 142.834 109.035 121.705 1 49.469  ? 808 GLY A O   1 
ATOM 2778 N N   . THR A 1 371 ? 141.176 109.045 123.199 1 50.49   ? 809 THR A N   1 
ATOM 2779 C CA  . THR A 1 371 ? 141.786 110.088 124.015 1 50.931  ? 809 THR A CA  1 
ATOM 2780 C C   . THR A 1 371 ? 142.989 109.563 124.795 1 47.292  ? 809 THR A C   1 
ATOM 2781 O O   . THR A 1 371 ? 143.593 110.341 125.522 1 55.101  ? 809 THR A O   1 
ATOM 2782 C CB  . THR A 1 371 ? 140.793 110.696 125.004 1 52.586  ? 809 THR A CB  1 
ATOM 2783 O OG1 . THR A 1 371 ? 140.69  109.864 126.151 1 50.859  ? 809 THR A OG1 1 
ATOM 2784 C CG2 . THR A 1 371 ? 139.401 110.855 124.445 1 55.448  ? 809 THR A CG2 1 
ATOM 2785 N N   . ASN A 1 372 ? 143.347 108.283 124.653 1 52.803  ? 810 ASN A N   1 
ATOM 2786 C CA  . ASN A 1 372 ? 144.519 107.738 125.329 1 56.383  ? 810 ASN A CA  1 
ATOM 2787 C C   . ASN A 1 372 ? 145.806 107.916 124.519 1 56.931  ? 810 ASN A C   1 
ATOM 2788 O O   . ASN A 1 372 ? 146.884 107.577 125.011 1 62.583  ? 810 ASN A O   1 
ATOM 2789 C CB  . ASN A 1 372 ? 144.334 106.262 125.663 1 59.228  ? 810 ASN A CB  1 
ATOM 2790 C CG  . ASN A 1 372 ? 143.307 106.033 126.748 1 65.135  ? 810 ASN A CG  1 
ATOM 2791 O OD1 . ASN A 1 372 ? 143.169 106.855 127.661 1 69.004  ? 810 ASN A OD1 1 
ATOM 2792 N ND2 . ASN A 1 372 ? 142.576 104.929 126.673 1 67.553  ? 810 ASN A ND2 1 
ATOM 2793 N N   . LEU A 1 373 ? 145.711 108.437 123.29  1 55.97   ? 811 LEU A N   1 
ATOM 2794 C CA  . LEU A 1 373 ? 146.874 108.603 122.427 1 55.146  ? 811 LEU A CA  1 
ATOM 2795 C C   . LEU A 1 373 ? 147.392 110.025 122.553 1 50.679  ? 811 LEU A C   1 
ATOM 2796 O O   . LEU A 1 373 ? 146.606 110.97  122.647 1 53.479  ? 811 LEU A O   1 
ATOM 2797 C CB  . LEU A 1 373 ? 146.496 108.288 120.983 1 55.77   ? 811 LEU A CB  1 
ATOM 2798 C CG  . LEU A 1 373 ? 145.698 107     120.774 1 55.066  ? 811 LEU A CG  1 
ATOM 2799 C CD1 . LEU A 1 373 ? 145.332 106.808 119.311 1 55.877  ? 811 LEU A CD1 1 
ATOM 2800 C CD2 . LEU A 1 373 ? 146.478 105.804 121.28  1 55.819  ? 811 LEU A CD2 1 
ATOM 2801 N N   . LEU A 1 374 ? 148.721 110.167 122.513 1 51.684  ? 812 LEU A N   1 
ATOM 2802 C CA  . LEU A 1 374 ? 149.354 111.428 122.833 1 49.964  ? 812 LEU A CA  1 
ATOM 2803 C C   . LEU A 1 374 ? 148.921 112.498 121.838 1 46.143  ? 812 LEU A C   1 
ATOM 2804 O O   . LEU A 1 374 ? 148.661 113.63  122.235 1 49.257  ? 812 LEU A O   1 
ATOM 2805 C CB  . LEU A 1 374 ? 150.872 111.262 122.891 1 53.306  ? 812 LEU A CB  1 
ATOM 2806 C CG  . LEU A 1 374 ? 151.402 110.359 124.013 1 60.494  ? 812 LEU A CG  1 
ATOM 2807 C CD1 . LEU A 1 374 ? 152.918 110.459 124.11  1 62.827  ? 812 LEU A CD1 1 
ATOM 2808 C CD2 . LEU A 1 374 ? 150.785 110.699 125.358 1 62.567  ? 812 LEU A CD2 1 
ATOM 2809 N N   . PRO A 1 375 ? 148.897 112.237 120.512 1 45.53   ? 813 PRO A N   1 
ATOM 2810 C CA  . PRO A 1 375 ? 148.532 113.286 119.57  1 46.298  ? 813 PRO A CA  1 
ATOM 2811 C C   . PRO A 1 375 ? 147.138 113.85  119.828 1 44.064  ? 813 PRO A C   1 
ATOM 2812 O O   . PRO A 1 375 ? 146.94  115.058 119.835 1 42.401  ? 813 PRO A O   1 
ATOM 2813 C CB  . PRO A 1 375 ? 148.676 112.621 118.21  1 46.962  ? 813 PRO A CB  1 
ATOM 2814 C CG  . PRO A 1 375 ? 149.624 111.467 118.458 1 44.272  ? 813 PRO A CG  1 
ATOM 2815 C CD  . PRO A 1 375 ? 149.295 110.991 119.835 1 46.261  ? 813 PRO A CD  1 
ATOM 2816 N N   . GLN A 1 376 ? 146.171 112.98  120.109 1 41.988  ? 814 GLN A N   1 
ATOM 2817 C CA  . GLN A 1 376 ? 144.837 113.452 120.435 1 44.677  ? 814 GLN A CA  1 
ATOM 2818 C C   . GLN A 1 376 ? 144.784 114.154 121.794 1 44.878  ? 814 GLN A C   1 
ATOM 2819 O O   . GLN A 1 376 ? 144.042 115.127 121.975 1 43.295  ? 814 GLN A O   1 
ATOM 2820 C CB  . GLN A 1 376 ? 143.833 112.313 120.425 1 46.131  ? 814 GLN A CB  1 
ATOM 2821 C CG  . GLN A 1 376 ? 143.552 111.753 119.04  1 49.071  ? 814 GLN A CG  1 
ATOM 2822 C CD  . GLN A 1 376 ? 144.655 110.879 118.494 1 46.851  ? 814 GLN A CD  1 
ATOM 2823 O OE1 . GLN A 1 376 ? 145.809 110.91  118.947 1 47.533  ? 814 GLN A OE1 1 
ATOM 2824 N NE2 . GLN A 1 376 ? 144.261 110.095 117.503 1 45.995  ? 814 GLN A NE2 1 
ATOM 2825 N N   . GLN A 1 377 ? 145.604 113.681 122.736 1 43.702  ? 815 GLN A N   1 
ATOM 2826 C CA  . GLN A 1 377 ? 145.723 114.336 124.025 1 45.397  ? 815 GLN A CA  1 
ATOM 2827 C C   . GLN A 1 377 ? 146.245 115.753 123.867 1 44.258  ? 815 GLN A C   1 
ATOM 2828 O O   . GLN A 1 377 ? 145.904 116.606 124.678 1 53.688  ? 815 GLN A O   1 
ATOM 2829 C CB  . GLN A 1 377 ? 146.603 113.527 124.974 1 46.379  ? 815 GLN A CB  1 
ATOM 2830 C CG  . GLN A 1 377 ? 145.799 112.493 125.741 1 48.016  ? 815 GLN A CG  1 
ATOM 2831 C CD  . GLN A 1 377 ? 146.604 111.768 126.788 1 51.926  ? 815 GLN A CD  1 
ATOM 2832 O OE1 . GLN A 1 377 ? 147.533 112.319 127.388 1 54.918  ? 815 GLN A OE1 1 
ATOM 2833 N NE2 . GLN A 1 377 ? 146.236 110.518 127.004 1 52.021  ? 815 GLN A NE2 1 
ATOM 2834 N N   . ALA A 1 378 ? 147.091 115.999 122.861 1 43.697  ? 816 ALA A N   1 
ATOM 2835 C CA  . ALA A 1 378 ? 147.642 117.326 122.64  1 42.907  ? 816 ALA A CA  1 
ATOM 2836 C C   . ALA A 1 378 ? 146.514 118.293 122.294 1 46.174  ? 816 ALA A C   1 
ATOM 2837 O O   . ALA A 1 378 ? 146.466 119.425 122.77  1 47.183  ? 816 ALA A O   1 
ATOM 2838 C CB  . ALA A 1 378 ? 148.687 117.29  121.543 1 43.001  ? 816 ALA A CB  1 
ATOM 2839 N N   . CYS A 1 379 ? 145.616 117.84  121.422 1 46.945  ? 817 CYS A N   1 
ATOM 2840 C CA  . CYS A 1 379 ? 144.498 118.665 121.009 1 48.677  ? 817 CYS A CA  1 
ATOM 2841 C C   . CYS A 1 379 ? 143.542 118.898 122.175 1 45.629  ? 817 CYS A C   1 
ATOM 2842 O O   . CYS A 1 379 ? 143.036 119.996 122.347 1 45.691  ? 817 CYS A O   1 
ATOM 2843 C CB  . CYS A 1 379 ? 143.776 118.03  119.835 1 51.93   ? 817 CYS A CB  1 
ATOM 2844 S SG  . CYS A 1 379 ? 144.647 118.247 118.262 1 52.119  ? 817 CYS A SG  1 
ATOM 2845 N N   . LEU A 1 380 ? 143.324 117.874 122.999 1 46.448  ? 818 LEU A N   1 
ATOM 2846 C CA  . LEU A 1 380 ? 142.556 118.067 124.217 1 47.974  ? 818 LEU A CA  1 
ATOM 2847 C C   . LEU A 1 380 ? 143.252 119.056 125.149 1 48.318  ? 818 LEU A C   1 
ATOM 2848 O O   . LEU A 1 380 ? 142.578 119.874 125.752 1 46.497  ? 818 LEU A O   1 
ATOM 2849 C CB  . LEU A 1 380 ? 142.331 116.743 124.928 1 47.121  ? 818 LEU A CB  1 
ATOM 2850 C CG  . LEU A 1 380 ? 141.418 115.75  124.214 1 50.076  ? 818 LEU A CG  1 
ATOM 2851 C CD1 . LEU A 1 380 ? 141.608 114.389 124.822 1 51.88   ? 818 LEU A CD1 1 
ATOM 2852 C CD2 . LEU A 1 380 ? 139.977 116.174 124.291 1 47.97   ? 818 LEU A CD2 1 
ATOM 2853 N N   . GLN A 1 381 ? 144.583 118.997 125.251 1 49.986  ? 819 GLN A N   1 
ATOM 2854 C CA  . GLN A 1 381 ? 145.332 119.855 126.157 1 50.585  ? 819 GLN A CA  1 
ATOM 2855 C C   . GLN A 1 381 ? 145.251 121.315 125.739 1 47.678  ? 819 GLN A C   1 
ATOM 2856 O O   . GLN A 1 381 ? 145.167 122.187 126.598 1 53.793  ? 819 GLN A O   1 
ATOM 2857 C CB  . GLN A 1 381 ? 146.792 119.417 126.27  1 52.722  ? 819 GLN A CB  1 
ATOM 2858 C CG  . GLN A 1 381 ? 147.071 118.615 127.531 1 60.268  ? 819 GLN A CG  1 
ATOM 2859 C CD  . GLN A 1 381 ? 148.189 117.607 127.381 1 67.06   ? 819 GLN A CD  1 
ATOM 2860 O OE1 . GLN A 1 381 ? 149.066 117.73  126.521 1 64.853  ? 819 GLN A OE1 1 
ATOM 2861 N NE2 . GLN A 1 381 ? 148.161 116.594 128.234 1 75.028  ? 819 GLN A NE2 1 
ATOM 2862 N N   . MET A 1 382 ? 145.314 121.604 124.438 1 51.699  ? 820 MET A N   1 
ATOM 2863 C CA  . MET A 1 382 ? 145.321 122.997 124.016 1 56.457  ? 820 MET A CA  1 
ATOM 2864 C C   . MET A 1 382 ? 143.967 123.645 124.303 1 54.09   ? 820 MET A C   1 
ATOM 2865 O O   . MET A 1 382 ? 143.845 124.867 124.276 1 58.679  ? 820 MET A O   1 
ATOM 2866 C CB  . MET A 1 382 ? 145.711 123.163 122.545 1 63.958  ? 820 MET A CB  1 
ATOM 2867 C CG  . MET A 1 382 ? 144.783 122.508 121.565 1 66.905  ? 820 MET A CG  1 
ATOM 2868 S SD  . MET A 1 382 ? 145.454 122.498 119.886 1 68.288  ? 820 MET A SD  1 
ATOM 2869 C CE  . MET A 1 382 ? 144.84  124.069 119.271 1 63.072  ? 820 MET A CE  1 
ATOM 2870 N N   . LEU A 1 383 ? 142.953 122.826 124.58  1 52.154  ? 821 LEU A N   1 
ATOM 2871 C CA  . LEU A 1 383 ? 141.654 123.319 125.012 1 54.403  ? 821 LEU A CA  1 
ATOM 2872 C C   . LEU A 1 383 ? 141.553 123.423 126.533 1 55.608  ? 821 LEU A C   1 
ATOM 2873 O O   . LEU A 1 383 ? 140.672 124.118 127.02  1 56.913  ? 821 LEU A O   1 
ATOM 2874 C CB  . LEU A 1 383 ? 140.554 122.402 124.493 1 55.568  ? 821 LEU A CB  1 
ATOM 2875 C CG  . LEU A 1 383 ? 140.266 122.49  122.997 1 55.396  ? 821 LEU A CG  1 
ATOM 2876 C CD1 . LEU A 1 383 ? 139.3   121.418 122.572 1 56.19   ? 821 LEU A CD1 1 
ATOM 2877 C CD2 . LEU A 1 383 ? 139.734 123.845 122.619 1 54.063  ? 821 LEU A CD2 1 
ATOM 2878 N N   . GLY A 1 384 ? 142.418 122.718 127.273 1 51.237  ? 822 GLY A N   1 
ATOM 2879 C CA  . GLY A 1 384 ? 142.417 122.774 128.725 1 49.053  ? 822 GLY A CA  1 
ATOM 2880 C C   . GLY A 1 384 ? 141.463 121.758 129.352 1 50.18   ? 822 GLY A C   1 
ATOM 2881 O O   . GLY A 1 384 ? 141.07  121.911 130.504 1 59.765  ? 822 GLY A O   1 
ATOM 2882 N N   . VAL A 1 385 ? 141.117 120.7   128.617 1 47.654  ? 823 VAL A N   1 
ATOM 2883 C CA  . VAL A 1 385 ? 140.119 119.756 129.085 1 48.572  ? 823 VAL A CA  1 
ATOM 2884 C C   . VAL A 1 385 ? 140.659 118.335 129.039 1 48.055  ? 823 VAL A C   1 
ATOM 2885 O O   . VAL A 1 385 ? 139.887 117.402 129.144 1 49.312  ? 823 VAL A O   1 
ATOM 2886 C CB  . VAL A 1 385 ? 138.833 119.861 128.244 1 49.978  ? 823 VAL A CB  1 
ATOM 2887 C CG1 . VAL A 1 385 ? 138.331 121.296 128.162 1 49.846  ? 823 VAL A CG1 1 
ATOM 2888 C CG2 . VAL A 1 385 ? 139.024 119.313 126.836 1 49.473  ? 823 VAL A CG2 1 
ATOM 2889 N N   . GLN A 1 386 ? 141.973 118.151 128.939 1 50.736  ? 824 GLN A N   1 
ATOM 2890 C CA  . GLN A 1 386 ? 142.516 116.812 128.804 1 47.455  ? 824 GLN A CA  1 
ATOM 2891 C C   . GLN A 1 386 ? 142.339 116.028 130.104 1 50.94   ? 824 GLN A C   1 
ATOM 2892 O O   . GLN A 1 386 ? 142.603 116.525 131.193 1 55.705  ? 824 GLN A O   1 
ATOM 2893 C CB  . GLN A 1 386 ? 143.985 116.891 128.401 1 51.74   ? 824 GLN A CB  1 
ATOM 2894 C CG  . GLN A 1 386 ? 144.595 115.55  128.031 1 53.166  ? 824 GLN A CG  1 
ATOM 2895 C CD  . GLN A 1 386 ? 145.064 114.76  129.231 1 53.359  ? 824 GLN A CD  1 
ATOM 2896 O OE1 . GLN A 1 386 ? 145.697 115.301 130.144 1 63.104  ? 824 GLN A OE1 1 
ATOM 2897 N NE2 . GLN A 1 386 ? 144.767 113.469 129.234 1 49.169  ? 824 GLN A NE2 1 
ATOM 2898 N N   . GLY A 1 387 ? 141.92  114.772 129.963 1 50.045  ? 825 GLY A N   1 
ATOM 2899 C CA  . GLY A 1 387 ? 141.9   113.82  131.055 1 57.033  ? 825 GLY A CA  1 
ATOM 2900 C C   . GLY A 1 387 ? 140.769 114.083 132.042 1 61.956  ? 825 GLY A C   1 
ATOM 2901 O O   . GLY A 1 387 ? 139.882 114.901 131.794 1 59.496  ? 825 GLY A O   1 
ATOM 2902 N N   . ALA A 1 388 ? 140.839 113.382 133.178 1 63.179  ? 826 ALA A N   1 
ATOM 2903 C CA  . ALA A 1 388 ? 139.855 113.511 134.24  1 63.811  ? 826 ALA A CA  1 
ATOM 2904 C C   . ALA A 1 388 ? 140.127 114.768 135.054 1 66.704  ? 826 ALA A C   1 
ATOM 2905 O O   . ALA A 1 388 ? 141.276 115.133 135.298 1 75.288  ? 826 ALA A O   1 
ATOM 2906 C CB  . ALA A 1 388 ? 139.871 112.288 135.121 1 65.594  ? 826 ALA A CB  1 
ATOM 2907 N N   . CYS A 1 389 ? 139.039 115.414 135.476 1 69.919  ? 827 CYS A N   1 
ATOM 2908 C CA  . CYS A 1 389 ? 139.102 116.555 136.369 1 76.948  ? 827 CYS A CA  1 
ATOM 2909 C C   . CYS A 1 389 ? 138.842 116.065 137.789 1 79.152  ? 827 CYS A C   1 
ATOM 2910 O O   . CYS A 1 389 ? 137.697 115.797 138.136 1 76.578  ? 827 CYS A O   1 
ATOM 2911 C CB  . CYS A 1 389 ? 138.089 117.602 135.926 1 75.336  ? 827 CYS A CB  1 
ATOM 2912 S SG  . CYS A 1 389 ? 137.786 118.896 137.153 1 80.899  ? 827 CYS A SG  1 
ATOM 2913 N N   . LYS A 1 390 ? 139.9   115.962 138.604 1 88.475  ? 828 LYS A N   1 
ATOM 2914 C CA  . LYS A 1 390 ? 139.816 115.271 139.882 1 93.578  ? 828 LYS A CA  1 
ATOM 2915 C C   . LYS A 1 390 ? 138.827 115.966 140.819 1 91.211  ? 828 LYS A C   1 
ATOM 2916 O O   . LYS A 1 390 ? 138.083 115.297 141.536 1 94.243  ? 828 LYS A O   1 
ATOM 2917 C CB  . LYS A 1 390 ? 141.193 115.169 140.545 1 101.477 ? 828 LYS A CB  1 
ATOM 2918 C CG  . LYS A 1 390 ? 141.235 114.223 141.74  1 111.186 ? 828 LYS A CG  1 
ATOM 2919 C CD  . LYS A 1 390 ? 142.637 113.788 142.156 1 119.93  ? 828 LYS A CD  1 
ATOM 2920 C CE  . LYS A 1 390 ? 143.453 113.233 141.023 1 125.451 ? 828 LYS A CE  1 
ATOM 2921 N NZ  . LYS A 1 390 ? 142.692 112.308 140.175 1 126.73  ? 828 LYS A NZ  1 
ATOM 2922 N N   . ASP A 1 391 ? 138.838 117.304 140.83  1 91.874  ? 829 ASP A N   1 
ATOM 2923 C CA  . ASP A 1 391 ? 138.019 118.064 141.762 1 96.05   ? 829 ASP A CA  1 
ATOM 2924 C C   . ASP A 1 391 ? 136.539 117.842 141.47  1 93.184  ? 829 ASP A C   1 
ATOM 2925 O O   . ASP A 1 391 ? 135.774 117.497 142.367 1 96.985  ? 829 ASP A O   1 
ATOM 2926 C CB  . ASP A 1 391 ? 138.359 119.544 141.73  1 103.329 ? 829 ASP A CB  1 
ATOM 2927 C CG  . ASP A 1 391 ? 139.653 119.91  142.438 1 113.144 ? 829 ASP A CG  1 
ATOM 2928 O OD1 . ASP A 1 391 ? 140.179 119.047 143.174 1 113.914 ? 829 ASP A OD1 1 
ATOM 2929 O OD2 . ASP A 1 391 ? 140.128 121.049 142.24  1 116.967 ? 829 ASP A OD2 1 
ATOM 2930 N N   . ASN A 1 392 ? 136.15  118.029 140.204 1 84.805  ? 830 ASN A N   1 
ATOM 2931 C CA  . ASN A 1 392 ? 134.749 118.09  139.819 1 75.916  ? 830 ASN A CA  1 
ATOM 2932 C C   . ASN A 1 392 ? 134.484 117.111 138.677 1 73.247  ? 830 ASN A C   1 
ATOM 2933 O O   . ASN A 1 392 ? 134.406 117.508 137.515 1 68.787  ? 830 ASN A O   1 
ATOM 2934 C CB  . ASN A 1 392 ? 134.374 119.515 139.434 1 74.489  ? 830 ASN A CB  1 
ATOM 2935 C CG  . ASN A 1 392 ? 132.92  119.657 139.057 1 76.463  ? 830 ASN A CG  1 
ATOM 2936 O OD1 . ASN A 1 392 ? 132.123 118.734 139.263 1 78.089  ? 830 ASN A OD1 1 
ATOM 2937 N ND2 . ASN A 1 392 ? 132.549 120.812 138.526 1 76.851  ? 830 ASN A ND2 1 
ATOM 2938 N N   . PRO A 1 393 ? 134.32  115.799 138.96  1 69.071  ? 831 PRO A N   1 
ATOM 2939 C CA  . PRO A 1 393 ? 134.267 114.797 137.903 1 67.472  ? 831 PRO A CA  1 
ATOM 2940 C C   . PRO A 1 393 ? 133.26  115.118 136.807 1 67.727  ? 831 PRO A C   1 
ATOM 2941 O O   . PRO A 1 393 ? 132.139 115.534 137.086 1 64.461  ? 831 PRO A O   1 
ATOM 2942 C CB  . PRO A 1 393 ? 133.888 113.521 138.639 1 68.412  ? 831 PRO A CB  1 
ATOM 2943 C CG  . PRO A 1 393 ? 134.441 113.758 140.032 1 69.165  ? 831 PRO A CG  1 
ATOM 2944 C CD  . PRO A 1 393 ? 134.175 115.208 140.298 1 69.994  ? 831 PRO A CD  1 
ATOM 2945 N N   . GLY A 1 394 ? 133.686 114.942 135.554 1 63.065  ? 832 GLY A N   1 
ATOM 2946 C CA  . GLY A 1 394 ? 132.834 115.215 134.411 1 55.789  ? 832 GLY A CA  1 
ATOM 2947 C C   . GLY A 1 394 ? 132.922 116.655 133.92  1 48.827  ? 832 GLY A C   1 
ATOM 2948 O O   . GLY A 1 394 ? 132.369 116.953 132.866 1 50.691  ? 832 GLY A O   1 
ATOM 2949 N N   . GLU A 1 395 ? 133.634 117.529 134.64  1 50.079  ? 833 GLU A N   1 
ATOM 2950 C CA  . GLU A 1 395 ? 133.692 118.929 134.263 1 51.858  ? 833 GLU A CA  1 
ATOM 2951 C C   . GLU A 1 395 ? 134.386 119.109 132.909 1 52.414  ? 833 GLU A C   1 
ATOM 2952 O O   . GLU A 1 395 ? 133.997 119.955 132.116 1 52.945  ? 833 GLU A O   1 
ATOM 2953 C CB  . GLU A 1 395 ? 134.38  119.745 135.353 1 55.201  ? 833 GLU A CB  1 
ATOM 2954 C CG  . GLU A 1 395 ? 134.453 121.231 135.028 1 63.612  ? 833 GLU A CG  1 
ATOM 2955 C CD  . GLU A 1 395 ? 133.132 121.825 134.568 1 72.136  ? 833 GLU A CD  1 
ATOM 2956 O OE1 . GLU A 1 395 ? 132.079 121.422 135.11  1 73.101  ? 833 GLU A OE1 1 
ATOM 2957 O OE2 . GLU A 1 395 ? 133.155 122.709 133.682 1 76.63   ? 833 GLU A OE2 1 
ATOM 2958 N N   . ASN A 1 396 ? 135.44  118.339 132.654 1 51.25   ? 834 ASN A N   1 
ATOM 2959 C CA  . ASN A 1 396 ? 136.203 118.484 131.423 1 49.671  ? 834 ASN A CA  1 
ATOM 2960 C C   . ASN A 1 396 ? 135.35  118.074 130.225 1 47.601  ? 834 ASN A C   1 
ATOM 2961 O O   . ASN A 1 396 ? 135.352 118.732 129.191 1 43.325  ? 834 ASN A O   1 
ATOM 2962 C CB  . ASN A 1 396 ? 137.488 117.669 131.482 1 50.37   ? 834 ASN A CB  1 
ATOM 2963 C CG  . ASN A 1 396 ? 138.581 118.355 132.259 1 49.418  ? 834 ASN A CG  1 
ATOM 2964 O OD1 . ASN A 1 396 ? 138.469 119.537 132.605 1 50.78   ? 834 ASN A OD1 1 
ATOM 2965 N ND2 . ASN A 1 396 ? 139.643 117.626 132.537 1 52.094  ? 834 ASN A ND2 1 
ATOM 2966 N N   . ALA A 1 397 ? 134.608 116.975 130.361 1 42.757  ? 835 ALA A N   1 
ATOM 2967 C CA  . ALA A 1 397 ? 133.748 116.532 129.279 1 44.841  ? 835 ALA A CA  1 
ATOM 2968 C C   . ALA A 1 397 ? 132.662 117.572 128.998 1 48.204  ? 835 ALA A C   1 
ATOM 2969 O O   . ALA A 1 397 ? 132.367 117.862 127.84  1 46.459  ? 835 ALA A O   1 
ATOM 2970 C CB  . ALA A 1 397 ? 133.161 115.195 129.592 1 44.442  ? 835 ALA A CB  1 
ATOM 2971 N N   . ARG A 1 398 ? 132.101 118.169 130.056 1 47.816  ? 836 ARG A N   1 
ATOM 2972 C CA  . ARG A 1 398 ? 131.091 119.198 129.893 1 48.297  ? 836 ARG A CA  1 
ATOM 2973 C C   . ARG A 1 398 ? 131.672 120.412 129.181 1 46.532  ? 836 ARG A C   1 
ATOM 2974 O O   . ARG A 1 398 ? 131.018 120.989 128.31  1 48.418  ? 836 ARG A O   1 
ATOM 2975 C CB  . ARG A 1 398 ? 130.51  119.622 131.244 1 50.674  ? 836 ARG A CB  1 
ATOM 2976 C CG  . ARG A 1 398 ? 129.522 118.604 131.789 1 55.426  ? 836 ARG A CG  1 
ATOM 2977 C CD  . ARG A 1 398 ? 128.909 119.062 133.11  1 59.118  ? 836 ARG A CD  1 
ATOM 2978 N NE  . ARG A 1 398 ? 129.391 118.222 134.209 1 64.793  ? 836 ARG A NE  1 
ATOM 2979 C CZ  . ARG A 1 398 ? 130.066 118.614 135.278 1 73.068  ? 836 ARG A CZ  1 
ATOM 2980 N NH1 . ARG A 1 398 ? 130.397 119.883 135.453 1 76.654  ? 836 ARG A NH1 1 
ATOM 2981 N NH2 . ARG A 1 398 ? 130.415 117.714 136.178 1 73.024  ? 836 ARG A NH2 1 
ATOM 2982 N N   . GLN A 1 399 ? 132.889 120.805 129.566 1 44.398  ? 837 GLN A N   1 
ATOM 2983 C CA  . GLN A 1 399 ? 133.524 121.957 128.953 1 46.072  ? 837 GLN A CA  1 
ATOM 2984 C C   . GLN A 1 399 ? 133.731 121.672 127.466 1 42.634  ? 837 GLN A C   1 
ATOM 2985 O O   . GLN A 1 399 ? 133.546 122.547 126.631 1 42.64   ? 837 GLN A O   1 
ATOM 2986 C CB  . GLN A 1 399 ? 134.838 122.269 129.668 1 46.686  ? 837 GLN A CB  1 
ATOM 2987 C CG  . GLN A 1 399 ? 135.598 123.427 129.046 1 48.712  ? 837 GLN A CG  1 
ATOM 2988 C CD  . GLN A 1 399 ? 134.814 124.711 129.139 1 52.325  ? 837 GLN A CD  1 
ATOM 2989 O OE1 . GLN A 1 399 ? 134.871 125.433 130.14  1 61.981  ? 837 GLN A OE1 1 
ATOM 2990 N NE2 . GLN A 1 399 ? 134.098 125.027 128.072 1 53.321  ? 837 GLN A NE2 1 
ATOM 2991 N N   . LEU A 1 400 ? 134.167 120.458 127.144 1 41.031  ? 838 LEU A N   1 
ATOM 2992 C CA  . LEU A 1 400 ? 134.425 120.113 125.761 1 43.252  ? 838 LEU A CA  1 
ATOM 2993 C C   . LEU A 1 400 ? 133.12  120.167 124.964 1 46.754  ? 838 LEU A C   1 
ATOM 2994 O O   . LEU A 1 400 ? 133.094 120.628 123.826 1 45.997  ? 838 LEU A O   1 
ATOM 2995 C CB  . LEU A 1 400 ? 135.086 118.746 125.65  1 44.211  ? 838 LEU A CB  1 
ATOM 2996 C CG  . LEU A 1 400 ? 135.42  118.31  124.218 1 45.267  ? 838 LEU A CG  1 
ATOM 2997 C CD1 . LEU A 1 400 ? 136.225 119.355 123.468 1 46.664  ? 838 LEU A CD1 1 
ATOM 2998 C CD2 . LEU A 1 400 ? 136.149 116.987 124.222 1 46.244  ? 838 LEU A CD2 1 
ATOM 2999 N N   . ALA A 1 401 ? 132.02  119.702 125.56  1 46.129  ? 839 ALA A N   1 
ATOM 3000 C CA  . ALA A 1 401 ? 130.724 119.78  124.903 1 43.898  ? 839 ALA A CA  1 
ATOM 3001 C C   . ALA A 1 401 ? 130.311 121.226 124.647 1 42.044  ? 839 ALA A C   1 
ATOM 3002 O O   . ALA A 1 401 ? 129.83  121.541 123.563 1 43.253  ? 839 ALA A O   1 
ATOM 3003 C CB  . ALA A 1 401 ? 129.689 119.071 125.726 1 47.601  ? 839 ALA A CB  1 
ATOM 3004 N N   . ARG A 1 402 ? 130.545 122.109 125.618 1 38.621  ? 840 ARG A N   1 
ATOM 3005 C CA  . ARG A 1 402 ? 130.262 123.521 125.442 1 43.45   ? 840 ARG A CA  1 
ATOM 3006 C C   . ARG A 1 402 ? 131.077 124.099 124.284 1 44.036  ? 840 ARG A C   1 
ATOM 3007 O O   . ARG A 1 402 ? 130.552 124.875 123.494 1 41.449  ? 840 ARG A O   1 
ATOM 3008 C CB  . ARG A 1 402 ? 130.522 124.3   126.736 1 46.533  ? 840 ARG A CB  1 
ATOM 3009 C CG  . ARG A 1 402 ? 129.546 123.925 127.844 1 51.247  ? 840 ARG A CG  1 
ATOM 3010 C CD  . ARG A 1 402 ? 129.989 124.381 129.228 1 57.198  ? 840 ARG A CD  1 
ATOM 3011 N NE  . ARG A 1 402 ? 129.804 125.811 129.463 1 63.992  ? 840 ARG A NE  1 
ATOM 3012 C CZ  . ARG A 1 402 ? 129.111 126.359 130.462 1 75.14   ? 840 ARG A CZ  1 
ATOM 3013 N NH1 . ARG A 1 402 ? 128.436 125.609 131.316 1 84.49   ? 840 ARG A NH1 1 
ATOM 3014 N NH2 . ARG A 1 402 ? 129.05  127.675 130.571 1 70.078  ? 840 ARG A NH2 1 
ATOM 3015 N N   . ILE A 1 403 ? 132.359 123.744 124.202 1 42.397  ? 841 ILE A N   1 
ATOM 3016 C CA  . ILE A 1 403 ? 133.23  124.252 123.153 1 44.203  ? 841 ILE A CA  1 
ATOM 3017 C C   . ILE A 1 403 ? 132.711 123.751 121.807 1 40.92   ? 841 ILE A C   1 
ATOM 3018 O O   . ILE A 1 403 ? 132.71  124.478 120.829 1 42.61   ? 841 ILE A O   1 
ATOM 3019 C CB  . ILE A 1 403 ? 134.688 123.831 123.409 1 46.799  ? 841 ILE A CB  1 
ATOM 3020 C CG1 . ILE A 1 403 ? 135.301 124.63  124.569 1 46.524  ? 841 ILE A CG1 1 
ATOM 3021 C CG2 . ILE A 1 403 ? 135.525 123.959 122.14  1 46.034  ? 841 ILE A CG2 1 
ATOM 3022 C CD1 . ILE A 1 403 ? 136.461 123.919 125.241 1 49.069  ? 841 ILE A CD1 1 
ATOM 3023 N N   . VAL A 1 404 ? 132.278 122.497 121.756 1 40.735  ? 842 VAL A N   1 
ATOM 3024 C CA  . VAL A 1 404 ? 131.801 121.934 120.51  1 43.617  ? 842 VAL A CA  1 
ATOM 3025 C C   . VAL A 1 404 ? 130.573 122.712 120.042 1 46.385  ? 842 VAL A C   1 
ATOM 3026 O O   . VAL A 1 404 ? 130.478 123.102 118.884 1 41.741  ? 842 VAL A O   1 
ATOM 3027 C CB  . VAL A 1 404 ? 131.509 120.439 120.652 1 45.84   ? 842 VAL A CB  1 
ATOM 3028 C CG1 . VAL A 1 404 ? 130.595 119.951 119.543 1 49.427  ? 842 VAL A CG1 1 
ATOM 3029 C CG2 . VAL A 1 404 ? 132.792 119.623 120.684 1 49.328  ? 842 VAL A CG2 1 
ATOM 3030 N N   . CYS A 1 405 ? 129.648 122.986 120.959 1 44.761  ? 843 CYS A N   1 
ATOM 3031 C CA  . CYS A 1 405 ? 128.451 123.732 120.609 1 43.132  ? 843 CYS A CA  1 
ATOM 3032 C C   . CYS A 1 405 ? 128.782 125.149 120.156 1 39.063  ? 843 CYS A C   1 
ATOM 3033 O O   . CYS A 1 405 ? 128.229 125.622 119.168 1 42.013  ? 843 CYS A O   1 
ATOM 3034 C CB  . CYS A 1 405 ? 127.462 123.747 121.764 1 45.779  ? 843 CYS A CB  1 
ATOM 3035 S SG  . CYS A 1 405 ? 125.79  124.247 121.261 1 47.525  ? 843 CYS A SG  1 
ATOM 3036 N N   . GLY A 1 406 ? 129.696 125.82  120.86  1 41.081  ? 844 GLY A N   1 
ATOM 3037 C CA  . GLY A 1 406 ? 130.124 127.155 120.475 1 39.876  ? 844 GLY A CA  1 
ATOM 3038 C C   . GLY A 1 406 ? 130.775 127.193 119.092 1 39.435  ? 844 GLY A C   1 
ATOM 3039 O O   . GLY A 1 406 ? 130.513 128.106 118.318 1 40.803  ? 844 GLY A O   1 
ATOM 3040 N N   . THR A 1 407 ? 131.637 126.218 118.794 1 38.257  ? 845 THR A N   1 
ATOM 3041 C CA  . THR A 1 407 ? 132.321 126.175 117.513 1 39.275  ? 845 THR A CA  1 
ATOM 3042 C C   . THR A 1 407 ? 131.295 125.913 116.416 1 38.426  ? 845 THR A C   1 
ATOM 3043 O O   . THR A 1 407 ? 131.383 126.477 115.335 1 37.413  ? 845 THR A O   1 
ATOM 3044 C CB  . THR A 1 407 ? 133.396 125.085 117.497 1 41.9    ? 845 THR A CB  1 
ATOM 3045 O OG1 . THR A 1 407 ? 134.154 125.218 118.696 1 41.626  ? 845 THR A OG1 1 
ATOM 3046 C CG2 . THR A 1 407 ? 134.315 125.216 116.298 1 43.629  ? 845 THR A CG2 1 
ATOM 3047 N N   . VAL A 1 408 ? 130.352 125.007 116.674 1 37.025  ? 846 VAL A N   1 
ATOM 3048 C CA  . VAL A 1 408 ? 129.299 124.735 115.711 1 39.784  ? 846 VAL A CA  1 
ATOM 3049 C C   . VAL A 1 408 ? 128.553 126.031 115.419 1 41.196  ? 846 VAL A C   1 
ATOM 3050 O O   . VAL A 1 408 ? 128.263 126.331 114.268 1 42.306  ? 846 VAL A O   1 
ATOM 3051 C CB  . VAL A 1 408 ? 128.34  123.639 116.204 1 40.249  ? 846 VAL A CB  1 
ATOM 3052 C CG1 . VAL A 1 408 ? 126.978 123.744 115.534 1 41.158  ? 846 VAL A CG1 1 
ATOM 3053 C CG2 . VAL A 1 408 ? 128.929 122.258 116.006 1 40.19   ? 846 VAL A CG2 1 
ATOM 3054 N N   . MET A 1 409 ? 128.276 126.815 116.459 1 39.654  ? 847 MET A N   1 
ATOM 3055 C CA  . MET A 1 409 ? 127.562 128.063 116.283 1 42.17   ? 847 MET A CA  1 
ATOM 3056 C C   . MET A 1 409 ? 128.365 129.045 115.425 1 45.189  ? 847 MET A C   1 
ATOM 3057 O O   . MET A 1 409 ? 127.797 129.698 114.558 1 42.621  ? 847 MET A O   1 
ATOM 3058 C CB  . MET A 1 409 ? 127.249 128.68  117.648 1 42.042  ? 847 MET A CB  1 
ATOM 3059 C CG  . MET A 1 409 ? 126.156 129.703 117.608 1 47.212  ? 847 MET A CG  1 
ATOM 3060 S SD  . MET A 1 409 ? 125.777 130.382 119.232 1 52.174  ? 847 MET A SD  1 
ATOM 3061 C CE  . MET A 1 409 ? 127.118 131.567 119.386 1 53.879  ? 847 MET A CE  1 
ATOM 3062 N N   . ALA A 1 410 ? 129.679 129.156 115.651 1 43.268  ? 848 ALA A N   1 
ATOM 3063 C CA  . ALA A 1 410 ? 130.517 130.02  114.832 1 44.118  ? 848 ALA A CA  1 
ATOM 3064 C C   . ALA A 1 410 ? 130.478 129.578 113.365 1 40.73   ? 848 ALA A C   1 
ATOM 3065 O O   . ALA A 1 410 ? 130.353 130.404 112.466 1 47.078  ? 848 ALA A O   1 
ATOM 3066 C CB  . ALA A 1 410 ? 131.924 130.025 115.388 1 43.108  ? 848 ALA A CB  1 
ATOM 3067 N N   . GLY A 1 411 ? 130.592 128.274 113.132 1 41.414  ? 849 GLY A N   1 
ATOM 3068 C CA  . GLY A 1 411 ? 130.545 127.729 111.786 1 46.318  ? 849 GLY A CA  1 
ATOM 3069 C C   . GLY A 1 411 ? 129.215 128.041 111.105 1 48.709  ? 849 GLY A C   1 
ATOM 3070 O O   . GLY A 1 411 ? 129.182 128.416 109.939 1 51.941  ? 849 GLY A O   1 
ATOM 3071 N N   . GLU A 1 412 ? 128.116 127.891 111.847 1 48.116  ? 850 GLU A N   1 
ATOM 3072 C CA  . GLU A 1 412 ? 126.793 128.199 111.328 1 48.115  ? 850 GLU A CA  1 
ATOM 3073 C C   . GLU A 1 412 ? 126.71  129.669 110.938 1 43.978  ? 850 GLU A C   1 
ATOM 3074 O O   . GLU A 1 412 ? 126.247 129.993 109.852 1 44.285  ? 850 GLU A O   1 
ATOM 3075 C CB  . GLU A 1 412 ? 125.699 127.898 112.351 1 48.838  ? 850 GLU A CB  1 
ATOM 3076 C CG  . GLU A 1 412 ? 125.528 126.412 112.627 1 49.434  ? 850 GLU A CG  1 
ATOM 3077 C CD  . GLU A 1 412 ? 124.952 125.65  111.453 1 57.069  ? 850 GLU A CD  1 
ATOM 3078 O OE1 . GLU A 1 412 ? 123.773 125.906 111.112 1 60.746  ? 850 GLU A OE1 1 
ATOM 3079 O OE2 . GLU A 1 412 ? 125.671 124.808 110.878 1 58.552  ? 850 GLU A OE2 1 
ATOM 3080 N N   . LEU A 1 413 ? 127.198 130.543 111.814 1 43.59   ? 851 LEU A N   1 
ATOM 3081 C CA  . LEU A 1 413 ? 127.174 131.969 111.549 1 47.33   ? 851 LEU A CA  1 
ATOM 3082 C C   . LEU A 1 413 ? 127.881 132.261 110.228 1 47.672  ? 851 LEU A C   1 
ATOM 3083 O O   . LEU A 1 413 ? 127.315 132.919 109.36  1 52.335  ? 851 LEU A O   1 
ATOM 3084 C CB  . LEU A 1 413 ? 127.833 132.68  112.728 1 46.921  ? 851 LEU A CB  1 
ATOM 3085 C CG  . LEU A 1 413 ? 127.697 134.198 112.786 1 50.55   ? 851 LEU A CG  1 
ATOM 3086 C CD1 . LEU A 1 413 ? 126.244 134.626 112.724 1 52.492  ? 851 LEU A CD1 1 
ATOM 3087 C CD2 . LEU A 1 413 ? 128.359 134.703 114.049 1 50.147  ? 851 LEU A CD2 1 
ATOM 3088 N N   . SER A 1 414 ? 129.094 131.726 110.057 1 50.242  ? 852 SER A N   1 
ATOM 3089 C CA  . SER A 1 414 ? 129.898 132.039 108.89  1 48.396  ? 852 SER A CA  1 
ATOM 3090 C C   . SER A 1 414 ? 129.235 131.495 107.623 1 45.137  ? 852 SER A C   1 
ATOM 3091 O O   . SER A 1 414 ? 129.103 132.219 106.643 1 46.945  ? 852 SER A O   1 
ATOM 3092 C CB  . SER A 1 414 ? 131.298 131.514 109.062 1 49.58   ? 852 SER A CB  1 
ATOM 3093 O OG  . SER A 1 414 ? 132.147 131.928 108.004 1 50.035  ? 852 SER A OG  1 
ATOM 3094 N N   . LEU A 1 415 ? 128.841 130.22  107.629 1 44.796  ? 853 LEU A N   1 
ATOM 3095 C CA  . LEU A 1 415 ? 128.318 129.59  106.427 1 48.397  ? 853 LEU A CA  1 
ATOM 3096 C C   . LEU A 1 415 ? 127.007 130.262 106.019 1 52.806  ? 853 LEU A C   1 
ATOM 3097 O O   . LEU A 1 415 ? 126.739 130.463 104.836 1 53.016  ? 853 LEU A O   1 
ATOM 3098 C CB  . LEU A 1 415 ? 128.127 128.091 106.617 1 50.516  ? 853 LEU A CB  1 
ATOM 3099 C CG  . LEU A 1 415 ? 127.464 127.361 105.442 1 56.789  ? 853 LEU A CG  1 
ATOM 3100 C CD1 . LEU A 1 415 ? 128.201 127.61  104.132 1 59.672  ? 853 LEU A CD1 1 
ATOM 3101 C CD2 . LEU A 1 415 ? 127.392 125.868 105.701 1 55.419  ? 853 LEU A CD2 1 
ATOM 3102 N N   . MET A 1 416 ? 126.183 130.6   107.008 1 50.977  ? 854 MET A N   1 
ATOM 3103 C CA  . MET A 1 416 ? 124.904 131.223 106.724 1 51.846  ? 854 MET A CA  1 
ATOM 3104 C C   . MET A 1 416 ? 125.105 132.615 106.137 1 50.456  ? 854 MET A C   1 
ATOM 3105 O O   . MET A 1 416 ? 124.389 132.997 105.219 1 51.548  ? 854 MET A O   1 
ATOM 3106 C CB  . MET A 1 416 ? 124.036 131.293 107.979 1 50.988  ? 854 MET A CB  1 
ATOM 3107 C CG  . MET A 1 416 ? 123.579 129.92  108.447 1 57.287  ? 854 MET A CG  1 
ATOM 3108 S SD  . MET A 1 416 ? 122.532 129.056 107.261 1 59.853  ? 854 MET A SD  1 
ATOM 3109 C CE  . MET A 1 416 ? 121.078 130.09  107.469 1 61.886  ? 854 MET A CE  1 
ATOM 3110 N N   . ALA A 1 417 ? 126.094 133.354 106.644 1 50.123  ? 855 ALA A N   1 
ATOM 3111 C CA  . ALA A 1 417 ? 126.437 134.642 106.065 1 49.786  ? 855 ALA A CA  1 
ATOM 3112 C C   . ALA A 1 417 ? 126.884 134.476 104.611 1 48.113  ? 855 ALA A C   1 
ATOM 3113 O O   . ALA A 1 417 ? 126.473 135.245 103.751 1 52.797  ? 855 ALA A O   1 
ATOM 3114 C CB  . ALA A 1 417 ? 127.498 135.315 106.903 1 48.867  ? 855 ALA A CB  1 
ATOM 3115 N N   . ALA A 1 418 ? 127.721 133.472 104.336 1 50.164  ? 856 ALA A N   1 
ATOM 3116 C CA  . ALA A 1 418 ? 128.204 133.246 102.983 1 52.791  ? 856 ALA A CA  1 
ATOM 3117 C C   . ALA A 1 418 ? 127.027 132.955 102.052 1 58.398  ? 856 ALA A C   1 
ATOM 3118 O O   . ALA A 1 418 ? 126.981 133.469 100.942 1 63.254  ? 856 ALA A O   1 
ATOM 3119 C CB  . ALA A 1 418 ? 129.203 132.114 102.965 1 50.099  ? 856 ALA A CB  1 
ATOM 3120 N N   . LEU A 1 419 ? 126.087 132.111 102.494 1 57.151  ? 857 LEU A N   1 
ATOM 3121 C CA  . LEU A 1 419 ? 124.943 131.747 101.672 1 58.255  ? 857 LEU A CA  1 
ATOM 3122 C C   . LEU A 1 419 ? 124.043 132.953 101.432 1 58.346  ? 857 LEU A C   1 
ATOM 3123 O O   . LEU A 1 419 ? 123.519 133.126 100.335 1 62.961  ? 857 LEU A O   1 
ATOM 3124 C CB  . LEU A 1 419 ? 124.167 130.61  102.324 1 55.921  ? 857 LEU A CB  1 
ATOM 3125 C CG  . LEU A 1 419 ? 124.864 129.255 102.267 1 59.923  ? 857 LEU A CG  1 
ATOM 3126 C CD1 . LEU A 1 419 ? 124.169 128.266 103.176 1 61.85   ? 857 LEU A CD1 1 
ATOM 3127 C CD2 . LEU A 1 419 ? 124.913 128.74  100.837 1 59.662  ? 857 LEU A CD2 1 
ATOM 3128 N N   . ALA A 1 420 ? 123.882 133.795 102.451 1 58.666  ? 858 ALA A N   1 
ATOM 3129 C CA  . ALA A 1 420 ? 122.992 134.938 102.344 1 60.569  ? 858 ALA A CA  1 
ATOM 3130 C C   . ALA A 1 420 ? 123.567 136.023 101.44  1 67.672  ? 858 ALA A C   1 
ATOM 3131 O O   . ALA A 1 420 ? 122.826 136.63  100.671 1 80.058  ? 858 ALA A O   1 
ATOM 3132 C CB  . ALA A 1 420 ? 122.688 135.485 103.705 1 59.234  ? 858 ALA A CB  1 
ATOM 3133 N N   . ALA A 1 421 ? 124.865 136.312 101.559 1 73.111  ? 859 ALA A N   1 
ATOM 3134 C CA  . ALA A 1 421 ? 125.479 137.257 100.639 1 78.096  ? 859 ALA A CA  1 
ATOM 3135 C C   . ALA A 1 421 ? 125.355 136.717 99.214  1 83.181  ? 859 ALA A C   1 
ATOM 3136 O O   . ALA A 1 421 ? 125.193 137.49  98.273  1 91.5    ? 859 ALA A O   1 
ATOM 3137 C CB  . ALA A 1 421 ? 126.912 137.537 101.034 1 77.359  ? 859 ALA A CB  1 
ATOM 3138 N N   . GLY A 1 422 ? 125.385 135.383 99.075  1 91.475  ? 860 GLY A N   1 
ATOM 3139 C CA  . GLY A 1 422 ? 125.084 134.72  97.818  1 101.329 ? 860 GLY A CA  1 
ATOM 3140 C C   . GLY A 1 422 ? 125.894 135.299 96.66   1 114.84  ? 860 GLY A C   1 
ATOM 3141 O O   . GLY A 1 422 ? 127.124 135.244 96.673  1 118.945 ? 860 GLY A O   1 
ATOM 3142 N N   . HIS A 1 423 ? 125.184 135.88  95.684  1 123.819 ? 861 HIS A N   1 
ATOM 3143 C CA  . HIS A 1 423 ? 125.795 136.431 94.485  1 133.93  ? 861 HIS A CA  1 
ATOM 3144 C C   . HIS A 1 423 ? 124.9   137.536 93.911  1 135.588 ? 861 HIS A C   1 
ATOM 3145 O O   . HIS A 1 423 ? 123.9   137.88  94.581  1 136.251 ? 861 HIS A O   1 
ATOM 3146 C CB  . HIS A 1 423 ? 126.015 135.31  93.465  1 141.595 ? 861 HIS A CB  1 
ATOM 3147 C CG  . HIS A 1 423 ? 124.997 134.231 93.615  1 150.199 ? 861 HIS A CG  1 
ATOM 3148 N ND1 . HIS A 1 423 ? 123.684 134.392 93.233  1 152.174 ? 861 HIS A ND1 1 
ATOM 3149 C CD2 . HIS A 1 423 ? 125.075 133.018 94.178  1 153.352 ? 861 HIS A CD2 1 
ATOM 3150 C CE1 . HIS A 1 423 ? 123.009 133.286 93.518  1 151.165 ? 861 HIS A CE1 1 
ATOM 3151 N NE2 . HIS A 1 423 ? 123.834 132.438 94.094  1 152.194 ? 861 HIS A NE2 1 
# 
