data_8S5D
# 
_entry.id   8S5D 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8S5D         pdb_00008s5d 10.2210/pdb8s5d/pdb 
WWPDB D_1292136827 ?            ?                   
EMDB  EMD-19732    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8S5D 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of Arf1-decorated membrane tubules' 
_pdbx_database_related.db_id          EMD-19732 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              kirsten.bacia@chemie.uni-halle.de 
_pdbx_contact_author.name_first         Kirsten 
_pdbx_contact_author.name_last          Bacia 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2092-3174 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Haupt, C.'       1 0000-0002-4748-6736 
'Semchonok, D.A.' 2 0000-0003-1622-9443 
'Stubbs, M.T.'    3 0000-0003-1278-9013 
'Bacia, K.'       4 0000-0002-2092-3174 
'Desfosses, A.'   5 0000-0002-6525-5042 
'Kastritis, P.L.' 6 0000-0002-1463-8422 
'Hamdi, F.'       7 0000-0002-2155-5000 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of Arf1-decorated membrane tubules' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Haupt, C.'       1 0000-0002-4748-6736 
primary 'Semchonok, D.A.' 2 0000-0003-1622-9443 
primary 'Stubbs, M.T.'    3 0000-0003-1278-9013 
primary 'Bacia, K.'       4 0000-0002-2092-3174 
primary 'Desfosses, A.'   5 0000-0002-6525-5042 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'ADP-ribosylation factor 1'                  20552.438 1 3.6.5.2 ? ? 
'A myristoyl group (derived from myristic acid) is covalently attached to the N-terminus via an amide bond.' 
2 non-polymer syn 'MAGNESIUM ION'                              24.305    1 ?       ? ? ? 
3 non-polymer syn "5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE" 539.246   1 ?       ? ? ? 
4 water       nat water                                        18.015    2 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGLFASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRH
YYRNTEGVIFVVDSNDRSRIGEAREVMQRMLNEDELRNAAWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQATCA
TSGEGLYEGLEWLSNSLKNST
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGLFASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRH
YYRNTEGVIFVVDSNDRSRIGEAREVMQRMLNEDELRNAAWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQATCA
TSGEGLYEGLEWLSNSLKNST
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'MAGNESIUM ION'                              MG  
3 "5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE" GSP 
4 water                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   LEU n 
1 4   PHE n 
1 5   ALA n 
1 6   SER n 
1 7   LYS n 
1 8   LEU n 
1 9   PHE n 
1 10  SER n 
1 11  ASN n 
1 12  LEU n 
1 13  PHE n 
1 14  GLY n 
1 15  ASN n 
1 16  LYS n 
1 17  GLU n 
1 18  MET n 
1 19  ARG n 
1 20  ILE n 
1 21  LEU n 
1 22  MET n 
1 23  VAL n 
1 24  GLY n 
1 25  LEU n 
1 26  ASP n 
1 27  GLY n 
1 28  ALA n 
1 29  GLY n 
1 30  LYS n 
1 31  THR n 
1 32  THR n 
1 33  VAL n 
1 34  LEU n 
1 35  TYR n 
1 36  LYS n 
1 37  LEU n 
1 38  LYS n 
1 39  LEU n 
1 40  GLY n 
1 41  GLU n 
1 42  VAL n 
1 43  ILE n 
1 44  THR n 
1 45  THR n 
1 46  ILE n 
1 47  PRO n 
1 48  THR n 
1 49  ILE n 
1 50  GLY n 
1 51  PHE n 
1 52  ASN n 
1 53  VAL n 
1 54  GLU n 
1 55  THR n 
1 56  VAL n 
1 57  GLN n 
1 58  TYR n 
1 59  LYS n 
1 60  ASN n 
1 61  ILE n 
1 62  SER n 
1 63  PHE n 
1 64  THR n 
1 65  VAL n 
1 66  TRP n 
1 67  ASP n 
1 68  VAL n 
1 69  GLY n 
1 70  GLY n 
1 71  GLN n 
1 72  ASP n 
1 73  ARG n 
1 74  ILE n 
1 75  ARG n 
1 76  SER n 
1 77  LEU n 
1 78  TRP n 
1 79  ARG n 
1 80  HIS n 
1 81  TYR n 
1 82  TYR n 
1 83  ARG n 
1 84  ASN n 
1 85  THR n 
1 86  GLU n 
1 87  GLY n 
1 88  VAL n 
1 89  ILE n 
1 90  PHE n 
1 91  VAL n 
1 92  VAL n 
1 93  ASP n 
1 94  SER n 
1 95  ASN n 
1 96  ASP n 
1 97  ARG n 
1 98  SER n 
1 99  ARG n 
1 100 ILE n 
1 101 GLY n 
1 102 GLU n 
1 103 ALA n 
1 104 ARG n 
1 105 GLU n 
1 106 VAL n 
1 107 MET n 
1 108 GLN n 
1 109 ARG n 
1 110 MET n 
1 111 LEU n 
1 112 ASN n 
1 113 GLU n 
1 114 ASP n 
1 115 GLU n 
1 116 LEU n 
1 117 ARG n 
1 118 ASN n 
1 119 ALA n 
1 120 ALA n 
1 121 TRP n 
1 122 LEU n 
1 123 VAL n 
1 124 PHE n 
1 125 ALA n 
1 126 ASN n 
1 127 LYS n 
1 128 GLN n 
1 129 ASP n 
1 130 LEU n 
1 131 PRO n 
1 132 GLU n 
1 133 ALA n 
1 134 MET n 
1 135 SER n 
1 136 ALA n 
1 137 ALA n 
1 138 GLU n 
1 139 ILE n 
1 140 THR n 
1 141 GLU n 
1 142 LYS n 
1 143 LEU n 
1 144 GLY n 
1 145 LEU n 
1 146 HIS n 
1 147 SER n 
1 148 ILE n 
1 149 ARG n 
1 150 ASN n 
1 151 ARG n 
1 152 PRO n 
1 153 TRP n 
1 154 PHE n 
1 155 ILE n 
1 156 GLN n 
1 157 ALA n 
1 158 THR n 
1 159 CYS n 
1 160 ALA n 
1 161 THR n 
1 162 SER n 
1 163 GLY n 
1 164 GLU n 
1 165 GLY n 
1 166 LEU n 
1 167 TYR n 
1 168 GLU n 
1 169 GLY n 
1 170 LEU n 
1 171 GLU n 
1 172 TRP n 
1 173 LEU n 
1 174 SER n 
1 175 ASN n 
1 176 SER n 
1 177 LEU n 
1 178 LYS n 
1 179 ASN n 
1 180 SER n 
1 181 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   181 
_entity_src_gen.gene_src_common_name               
;brewer's yeast
;
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'ARF1, YDL192W, D1244' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Saccharomyces cerevisiae' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     4932 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                      ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE                                     ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE                                   ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                              ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE                                     ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE                                    ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                              ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE                                      ? 'C2 H5 N O2'          75.067  
GSP non-polymer         . "5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE" ? 'C10 H16 N5 O13 P3 S' 539.246 
HIS 'L-peptide linking' y HISTIDINE                                    ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER                                        ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                   ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE                                      ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE                                       ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE                                   ? 'C5 H11 N O2 S'       149.211 
MG  non-polymer         . 'MAGNESIUM ION'                              ? 'Mg 2'                24.305  
PHE 'L-peptide linking' y PHENYLALANINE                                ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE                                      ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE                                       ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE                                    ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                   ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE                                     ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE                                       ? 'C5 H11 N O2'         117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLY 2   2   ?   ?   ?   A . n 
A 1 3   LEU 3   3   ?   ?   ?   A . n 
A 1 4   PHE 4   4   ?   ?   ?   A . n 
A 1 5   ALA 5   5   ?   ?   ?   A . n 
A 1 6   SER 6   6   ?   ?   ?   A . n 
A 1 7   LYS 7   7   ?   ?   ?   A . n 
A 1 8   LEU 8   8   ?   ?   ?   A . n 
A 1 9   PHE 9   9   ?   ?   ?   A . n 
A 1 10  SER 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  LEU 12  12  ?   ?   ?   A . n 
A 1 13  PHE 13  13  ?   ?   ?   A . n 
A 1 14  GLY 14  14  ?   ?   ?   A . n 
A 1 15  ASN 15  15  ?   ?   ?   A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  GLU 17  17  17  GLU GLU A . n 
A 1 18  MET 18  18  18  MET MET A . n 
A 1 19  ARG 19  19  19  ARG ARG A . n 
A 1 20  ILE 20  20  20  ILE ILE A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  MET 22  22  22  MET MET A . n 
A 1 23  VAL 23  23  23  VAL VAL A . n 
A 1 24  GLY 24  24  24  GLY GLY A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  ALA 28  28  28  ALA ALA A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LYS 30  30  30  LYS LYS A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  THR 32  32  32  THR THR A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  TYR 35  35  35  TYR TYR A . n 
A 1 36  LYS 36  36  36  LYS LYS A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  LYS 38  38  38  LYS LYS A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  GLU 41  41  41  GLU GLU A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  ILE 46  46  46  ILE ILE A . n 
A 1 47  PRO 47  47  47  PRO PRO A . n 
A 1 48  THR 48  48  48  THR THR A . n 
A 1 49  ILE 49  49  49  ILE ILE A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  PHE 51  51  51  PHE PHE A . n 
A 1 52  ASN 52  52  52  ASN ASN A . n 
A 1 53  VAL 53  53  53  VAL VAL A . n 
A 1 54  GLU 54  54  54  GLU GLU A . n 
A 1 55  THR 55  55  55  THR THR A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  TYR 58  58  58  TYR TYR A . n 
A 1 59  LYS 59  59  59  LYS LYS A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  ILE 61  61  61  ILE ILE A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  PHE 63  63  63  PHE PHE A . n 
A 1 64  THR 64  64  64  THR THR A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  TRP 66  66  66  TRP TRP A . n 
A 1 67  ASP 67  67  67  ASP ASP A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  GLN 71  71  71  GLN GLN A . n 
A 1 72  ASP 72  72  72  ASP ASP A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  TRP 78  78  78  TRP TRP A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  TYR 81  81  81  TYR TYR A . n 
A 1 82  TYR 82  82  82  TYR TYR A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  GLU 86  86  86  GLU GLU A . n 
A 1 87  GLY 87  87  87  GLY GLY A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  PHE 90  90  90  PHE PHE A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  ASP 96  96  96  ASP ASP A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  SER 98  98  98  SER SER A . n 
A 1 99  ARG 99  99  99  ARG ARG A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 GLU 102 102 102 GLU GLU A . n 
A 1 103 ALA 103 103 103 ALA ALA A . n 
A 1 104 ARG 104 104 104 ARG ARG A . n 
A 1 105 GLU 105 105 105 GLU GLU A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 MET 107 107 107 MET MET A . n 
A 1 108 GLN 108 108 108 GLN GLN A . n 
A 1 109 ARG 109 109 109 ARG ARG A . n 
A 1 110 MET 110 110 110 MET MET A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 ASN 112 112 112 ASN ASN A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 GLU 115 115 115 GLU GLU A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 ARG 117 117 117 ARG ARG A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 ALA 120 120 120 ALA ALA A . n 
A 1 121 TRP 121 121 121 TRP TRP A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 ASN 126 126 126 ASN ASN A . n 
A 1 127 LYS 127 127 127 LYS LYS A . n 
A 1 128 GLN 128 128 128 GLN GLN A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 PRO 131 131 131 PRO PRO A . n 
A 1 132 GLU 132 132 132 GLU GLU A . n 
A 1 133 ALA 133 133 133 ALA ALA A . n 
A 1 134 MET 134 134 134 MET MET A . n 
A 1 135 SER 135 135 135 SER SER A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 ILE 139 139 139 ILE ILE A . n 
A 1 140 THR 140 140 140 THR THR A . n 
A 1 141 GLU 141 141 141 GLU GLU A . n 
A 1 142 LYS 142 142 142 LYS LYS A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 HIS 146 146 146 HIS HIS A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 ILE 148 148 148 ILE ILE A . n 
A 1 149 ARG 149 149 149 ARG ARG A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 ARG 151 151 151 ARG ARG A . n 
A 1 152 PRO 152 152 152 PRO PRO A . n 
A 1 153 TRP 153 153 153 TRP TRP A . n 
A 1 154 PHE 154 154 154 PHE PHE A . n 
A 1 155 ILE 155 155 155 ILE ILE A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 CYS 159 159 159 CYS CYS A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 THR 161 161 161 THR THR A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 GLU 164 164 164 GLU ALA A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 TYR 167 167 167 TYR TYR A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 GLU 171 171 171 GLU GLU A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 LEU 173 173 173 LEU LEU A . n 
A 1 174 SER 174 174 174 SER SER A . n 
A 1 175 ASN 175 175 175 ASN ASN A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 LYS 178 178 178 LYS LYS A . n 
A 1 179 ASN 179 179 ?   ?   ?   A . n 
A 1 180 SER 180 180 ?   ?   ?   A . n 
A 1 181 THR 181 181 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 GSP ? ? GSP ? ? 'SUBJECT OF INVESTIGATION' ? 
2 MG  ? ? MG  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 MG  1 201 201 MG  MG  A . 
C 3 GSP 1 202 202 GSP GSP A . 
D 4 HOH 1 301 206 HOH HOH A . 
D 4 HOH 2 302 205 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A GLU 164 ? CG  ? A GLU 164 CG  
2 1 Y 1 A GLU 164 ? CD  ? A GLU 164 CD  
3 1 Y 1 A GLU 164 ? OE1 ? A GLU 164 OE1 
4 1 Y 1 A GLU 164 ? OE2 ? A GLU 164 OE2 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8S5D 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8S5D 
_struct.title                        'Cryo-EM structure of Arf1-decorated membrane tubules' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8S5D 
_struct_keywords.text            'Arf1, protein-membrane interaction, membrane tubules, helical structure, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ARF1_YEAST 
_struct_ref.pdbx_db_accession          P11076 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MGLFASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRH
YYRNTEGVIFVVDSNDRSRIGEAREVMQRMLNEDELRNAAWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQATCA
TSGEGLYEGLEWLSNSLKNST
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8S5D 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 181 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P11076 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  181 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       181 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       'UCSF CHIMERA 1.17.3_b42480.' 
_pdbx_struct_assembly.oligomeric_details   241-meric 
_pdbx_struct_assembly.oligomeric_count     241 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241
;
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1   'identity operation'       1_555 x,y,z 1.0       0.0       0.0       0.0        0.0       1.0       0.0       0.0        0.0 
0.0       1.0 0.0       
2   'point symmetry operation' ?     ?     0.93495   -0.35478  0.0       123.36154  0.35478   0.93495   0.0       -85.1332   0.0 
0.0       1.0 5.82074   
3   'point symmetry operation' ?     ?     0.748261  -0.663404 0.0       268.9027   0.663404  0.748261  0.0       -120.96229 0.0 
0.0       1.0 11.64187  
4   'point symmetry operation' ?     ?     0.464224  -0.885718 0.0       417.68702  0.885718  0.464224  0.0       -102.8258  0.0 
0.0       1.0 17.46338  
5   'point symmetry operation' ?     ?     0.11979   -0.992799 0.0       550.359    0.992799  0.11979   0.0       -33.08292  0.0 
0.0       1.0 23.28433  
6   'point symmetry operation' ?     ?     -0.240228 -0.970716 0.0       649.65659  0.970716  -0.240228 0.0       79.19243   0.0 
0.0       1.0 29.10522  
7   'point symmetry operation' ?     ?     -0.568992 -0.822343 0.0       702.66263  0.822343  -0.568992 0.0       219.39305  0.0 
0.0       1.0 34.92622  
8   'point symmetry operation' ?     ?     -0.82373  -0.566982 0.0       702.47899  0.566982  -0.82373  0.0       369.27911  0.0 
0.0       1.0 40.74666  
9   'point symmetry operation' ?     ?     -0.971301 -0.237855 0.0       649.13132  0.237855  -0.971301 0.0       509.35025  0.0 
0.0       1.0 46.56831  
10  'point symmetry operation' ?     ?     -0.992504 0.122216  0.0       549.55922  -0.122216 -0.992504 0.0       621.38212  0.0 
0.0       1.0 52.38907  
11  'point symmetry operation' ?     ?     -0.884581 0.466386  0.0       416.71805  -0.466386 -0.884581 0.0       690.80074  0.0 
0.0       1.0 58.20988  
12  'point symmetry operation' ?     ?     -0.661574 0.74988   0.0       267.88909  -0.74988  -0.661574 -0.000001 708.57402  0.0 
0.0       1.0 64.03115  
13  'point symmetry operation' ?     ?     -0.352495 0.935814  0.0       122.43653  -0.935814 -0.352495 -0.000001 672.38947  0.0 
0.0       1.0 69.85158  
14  'point symmetry operation' ?     ?     0.002443  0.999997  0.0       -0.71667   -0.999997 0.002443  0.0       586.95475  0.0 
0.0       1.0 75.67293  
15  'point symmetry operation' ?     ?     0.357065  0.93408   -0.000001 -85.54861  -0.93408  0.357065  0.0       463.38526  0.0 
0.000001  1.0 81.49381  
16  'point symmetry operation' ?     ?     0.665231  0.746638  0.0       -121.02202 -0.746638 0.665231  0.0       317.75713  0.0 
0.0       1.0 87.31498  
17  'point symmetry operation' ?     ?     0.88685   0.462058  0.0       -102.52176 -0.462058 0.88685   0.0       169.0172   0.0 
0.0       1.0 93.1362   
18  'point symmetry operation' ?     ?     0.993089  0.117364  0.0       -32.45521  -0.117364 0.993089  0.0       36.51657   0.0 
0.0       1.0 98.95717  
19  'point symmetry operation' ?     ?     0.970127  -0.242599 0.0       80.06253   0.242599  0.970127  0.0       -62.5069   0.0 
0.0       1.0 104.77838 
20  'point symmetry operation' ?     ?     0.82095   -0.571    0.0       220.39235  0.571     0.82095   0.0       -115.16922 0.0 
0.0       1.0 110.59913 
21  'point symmetry operation' ?     ?     0.564967  -0.825114 0.0       370.27732  0.825114  0.564967  0.0       -114.61949 0.0 
0.0       1.0 116.42023 
22  'point symmetry operation' ?     ?     0.235482  -0.971879 0.0       510.21705  0.971879  0.235482  0.0       -60.93019  0.0 
0.0       1.0 122.24132 
23  'point symmetry operation' ?     ?     -0.12464  -0.992202 0.0       622.00605  0.992202  -0.12464  0.0       38.91503   0.0 
0.0       1.0 128.062   
24  'point symmetry operation' ?     ?     -0.468547 -0.883439 0.0       691.09941  0.883439  -0.468547 0.0       171.92622  0.0 
0.0       1.0 133.88323 
25  'point symmetry operation' ?     ?     -0.751495 -0.659739 0.0       708.50905  0.659739  -0.751495 0.0       320.79756  0.0 
0.0       1.0 139.70388 
26  'point symmetry operation' ?     ?     -0.936672 -0.350208 0.0       671.96955  0.350208  -0.936672 -0.000001 466.16217  0.0 
-0.000001 1.0 145.52498 
27  'point symmetry operation' ?     ?     -0.999988 0.004887  0.0       586.23425  -0.004887 -0.999988 0.0       589.10543  0.0 
0.0       1.0 151.346   
28  'point symmetry operation' ?     ?     -0.933205 0.359345  0.0       462.45759  -0.359345 -0.933205 0.0       673.63572  0.0 
0.0       1.0 157.16708 
29  'point symmetry operation' ?     ?     -0.74501  0.667053  0.0       316.74358  -0.667053 -0.74501  0.000001  708.75312  0.0 
0.0       1.0 162.98849 
30  'point symmetry operation' ?     ?     -0.45989  0.887976  0.0       168.04977  -0.887976 -0.45989  -0.000001 689.88979  0.0 
0.0       1.0 168.80895 
31  'point symmetry operation' ?     ?     -0.114937 0.993373  0.0       35.71972   -0.993373 -0.114937 0.0       619.49901  0.0 
0.0       1.0 174.63035 
32  'point symmetry operation' ?     ?     0.244969  0.969531  0.0       -63.02803  -0.969531 0.244969  0.0       506.74007  0.0 
0.0       1.0 180.45134 
33  'point symmetry operation' ?     ?     0.573005  0.819552  0.0       -115.34804 -0.819552 0.573005  0.0       366.28159  0.0 
0.0       1.0 186.27231 
34  'point symmetry operation' ?     ?     0.826491  0.562949  0.0       -114.43229 -0.562949 0.826491  0.0       216.39812  0.0 
0.0       1.0 192.09335 
35  'point symmetry operation' ?     ?     0.972451  0.233106  -0.000001 -60.40036  -0.233106 0.972451  0.0       76.58985   
0.000001  0.0       1.0 197.91423 
36  'point symmetry operation' ?     ?     0.991894  -0.127064 0.0       39.71757   0.127064  0.991894  0.0       -34.9546   0.0 
0.0       1.0 203.73507 
37  'point symmetry operation' ?     ?     0.882291  -0.470704 0.0       172.89705  0.470704  0.882291  0.0       -103.72309 0.0 
0.0       1.0 209.55573 
38  'point symmetry operation' ?     ?     0.657901  -0.753104 0.0       321.81104  0.753104  0.657901  0.0       -120.76846 0.0 
0.0       1.0 215.37674 
39  'point symmetry operation' ?     ?     0.347918  -0.937525 0.0       467.08546  0.937525  0.347918  0.0       -83.87378  0.0 
0.0       1.0 221.19796 
40  'point symmetry operation' ?     ?     -0.00733  -0.999973 0.0       589.82007  0.999973  -0.00733  0.0       2.16155    0.0 
0.0       1.0 227.01881 
41  'point symmetry operation' ?     ?     -0.361624 -0.932324 0.0       674.04638  0.932324  -0.361624 0.0       126.14487  0.0 
0.0       1.0 232.83967 
42  'point symmetry operation' ?     ?     -0.668871 -0.743379 0.0       708.80792  0.743379  -0.668871 0.000001  271.94338  
-0.000001 0.0       1.0 238.66083 
43  'point symmetry operation' ?     ?     -0.889097 -0.457719 0.0       689.58095  0.457719  -0.889097 0.000001  420.59153  0.0 
0.000001  1.0 244.48186 
44  'point symmetry operation' ?     ?     -0.993651 -0.112509 0.0       618.86707  0.112509  -0.993651 0.0       552.74876  0.0 
0.0       1.0 250.30316 
45  'point symmetry operation' ?     ?     -0.968929 0.247337  0.0       505.86736  -0.247337 -0.968929 0.0       651.22118  0.0 
0.0       1.0 256.12373 
46  'point symmetry operation' ?     ?     -0.81815  0.575005  0.0       365.28151  -0.575005 -0.81815  0.0       703.19719  0.0 
0.0       1.0 261.94511 
47  'point symmetry operation' ?     ?     -0.560928 0.827864  0.0       215.40122  -0.827864 -0.560928 0.0       701.9156   0.0 
0.0       1.0 267.76618 
48  'point symmetry operation' ?     ?     -0.230729 0.973018  0.0       75.72481   -0.973018 -0.230729 -0.000001 647.54196  
-0.000001 0.0       1.0 273.58693 
49  'point symmetry operation' ?     ?     0.129488  0.991581  0.0       -35.57441  -0.991581 0.129488  0.0       547.15168  0.0 
0.0       1.0 279.4078  
50  'point symmetry operation' ?     ?     0.472858  0.881138  0.0       -104.01737 -0.881138 0.472858  0.0       413.80453  0.0 
0.0       1.0 285.22884 
51  'point symmetry operation' ?     ?     0.75471   0.656059  0.0       -120.69889 -0.656059 0.75471   0.0       264.84961  0.0 
0.0       1.0 291.04992 
52  'point symmetry operation' ?     ?     0.938372  0.345626  0.0       -83.44927  -0.345626 0.938372  0.000001  119.66547  0.0 
0.0       1.0 296.87081 
53  'point symmetry operation' ?     ?     0.999952  -0.009774 0.0       2.88601    0.009774  0.999952  0.0       -2.85778   0.0 
0.0       1.0 302.6918  
54  'point symmetry operation' ?     ?     0.931437  -0.363902 0.0       127.074    0.363902  0.931437  0.0       -86.78202  0.0 
0.0       1.0 308.51304 
55  'point symmetry operation' ?     ?     0.741742  -0.670685 0.0       272.95766  0.670685  0.741742  0.0       -121.18624 0.0 
0.0       1.0 314.33364 
56  'point symmetry operation' ?     ?     0.455545  -0.890213 -0.000001 421.55867  0.890213  0.455545  0.0       -101.59667 0.0 
-0.000001 1.0 320.15472 
57  'point symmetry operation' ?     ?     0.110081  -0.993923 0.0       553.5415   0.993923  0.110081  0.0       -30.56022  0.0 
0.0       1.0 325.976   
58  'point symmetry operation' ?     ?     -0.249704 -0.968322 0.0       651.73769  0.968322  -0.249704 0.0       82.68048   0.0 
0.0       1.0 331.79688 
59  'point symmetry operation' ?     ?     -0.577003 -0.816742 0.0       703.37053  0.816742  -0.577003 0.0       223.39243  0.0 
0.0       1.0 337.61808 
60  'point symmetry operation' ?     ?     -0.829233 -0.558903 0.0       701.72217  0.558903  -0.829233 0.0       373.26921  0.0 
0.0       1.0 343.43892 
61  'point symmetry operation' ?     ?     -0.973579 -0.228351 0.0       647.00793  0.228351  -0.973579 0.0       512.81223  0.0 
0.0       1.0 349.25997 
62  'point symmetry operation' ?     ?     -0.991262 0.13191   0.0       546.34585  -0.13191  -0.991262 0.0       623.86614  0.0 
0.0       1.0 355.08112 
63  'point symmetry operation' ?     ?     -0.87998  0.47501   0.0       412.83178  -0.47501  -0.87998  0.0       691.98324  0.0 
0.0       1.0 360.90203 
64  'point symmetry operation' ?     ?     -0.654213 0.75631   0.0       263.83681  -0.75631  -0.654213 0.0       708.30073  0.0 
0.0       1.0 366.72323 
65  'point symmetry operation' ?     ?     -0.343332 0.939214  0.0       118.7444   -0.939214 -0.343332 0.0       670.69594  0.0 
0.0       1.0 372.54423 
66  'point symmetry operation' ?     ?     0.012217  0.999925  0.0       -3.56766   -0.999925 0.012217  0.0       584.06199  0.0 
0.0       1.0 378.36474 
67  'point symmetry operation' ?     ?     0.366176  0.930546  0.0       -87.18792  -0.930546 0.366176  0.0       459.66951  0.0 
0.0       1.0 384.18578 
68  'point symmetry operation' ?     ?     0.672496  0.740101  0.0       -121.2361  -0.740101 0.672496  0.0       313.7013   0.0 
0.0       1.0 390.0065  
69  'point symmetry operation' ?     ?     0.891323  0.453368  -0.000001 -101.28261 -0.453368 0.891323  0.0       165.14941  
0.000001  0.0       1.0 395.8281  
70  'point symmetry operation' ?     ?     0.994189  0.107652  0.0       -29.92462  -0.107652 0.994189  0.0       33.33984   0.0 
0.0       1.0 401.64948 
71  'point symmetry operation' ?     ?     0.967709  -0.252069 0.0       83.55553   0.252069  0.967709  0.0       -64.5791   0.0 
0.0       1.0 407.47044 
72  'point symmetry operation' ?     ?     0.81533   -0.578997 0.0       224.39399  0.578997  0.81533   0.0       -115.86763 0.0 
0.0       1.0 413.29086 
73  'point symmetry operation' ?     ?     0.556875  -0.830596 0.0       374.26621  0.830596  0.556875  0.0       -113.85302 0.0 
0.0       1.0 419.11189 
74  'point symmetry operation' ?     ?     0.225972  -0.974134 0.0       513.67441  0.974134  0.225972  0.0       -58.79837  0.0 
0.0       1.0 424.9326  
75  'point symmetry operation' ?     ?     -0.134332 -0.990936 0.0       624.48183  0.990936  -0.134332 0.0       42.13463   0.0 
0.0       1.0 430.75393 
76  'point symmetry operation' ?     ?     -0.477158 -0.878817 0.0       692.27218  0.878817  -0.477158 -0.000001 175.815    
0.000001  0.0       1.0 436.57534 
77  'point symmetry operation' ?     ?     -0.757907 -0.652363 0.000001  708.22562  0.652363  -0.757907 0.0       324.84944  0.0 
0.0       1.0 442.39588 
78  'point symmetry operation' ?     ?     -0.94005  -0.341036 0.0       670.26669  0.341036  -0.94005  0.0       469.84894  0.0 
0.0       1.0 448.21707 
79  'point symmetry operation' ?     ?     -0.999893 0.01466   0.0       583.33439  -0.01466  -0.999893 0.0       591.94962  0.0 
0.0       1.0 454.03805 
80  'point symmetry operation' ?     ?     -0.929648 0.368449  0.0       458.73766  -0.368449 -0.929648 -0.000001 675.26596  0.0 
-0.000001 1.0 459.85959 
81  'point symmetry operation' ?     ?     -0.738456 0.674302  0.0       312.68764  -0.674302 -0.738456 0.0       708.95699  0.0 
0.0       1.0 465.67963 
82  'point symmetry operation' ?     ?     -0.774724 -0.6323   0.0       707.27218  0.6323    -0.774724 0.0       335.68642  0.0 
0.0       1.0 5.82089   
83  'point symmetry operation' ?     ?     -0.948655 -0.316311 -0.000001 665.53114  0.316311  -0.948655 0.0       479.64283  
-0.000001 0.0       1.0 11.64206  
84  'point symmetry operation' ?     ?     -0.999166 0.04083   0.0       575.43129  -0.04083  -0.999166 0.0       599.42577  0.0 
0.0       1.0 17.46332  
85  'point symmetry operation' ?     ?     -0.919685 0.392658  0.0       448.69671  -0.392658 -0.919685 0.0       679.45111  0.0 
0.0       1.0 23.28438  
86  'point symmetry operation' ?     ?     -0.720551 0.693402  0.0       301.81445  -0.693402 -0.720551 0.0       709.30852  0.0 
0.0       1.0 29.10514  
87  'point symmetry operation' ?     ?     -0.427674 0.903933  0.000001  153.89385  -0.903933 -0.427674 0.0       685.11241  0.0 
-0.000001 1.0 34.92587  
88  'point symmetry operation' ?     ?     -0.079155 0.996862  -0.000001 24.18088   -0.996862 -0.079155 0.0       610.00993  0.0 
0.000001  1.0 40.74671  
89  'point symmetry operation' ?     ?     0.279662  0.960099  0.0       -70.45022  -0.960099 0.279662  0.0       493.77419  0.0 
0.0       1.0 46.56767  
90  'point symmetry operation' ?     ?     0.602094  0.798425  0.0       -117.68709 -0.798425 0.602094  0.0       351.52668  0.0 
0.0       1.0 52.38899  
91  'point symmetry operation' ?     ?     0.846193  0.532876  0.0       -111.38425 -0.532876 0.846193  0.0       201.77237  0.0 
0.0       1.0 58.20983  
92  'point symmetry operation' ?     ?     0.980202  0.198     0.0       -52.36241  -0.198    0.980202  0.0       63.99688   0.0 
0.0       1.0 64.03108  
93  'point symmetry operation' ?     ?     0.986686  -0.162637 0.0       51.70109   0.162637  0.986686  0.0       -43.87665  0.0 
0.0       1.0 69.85164  
94  'point symmetry operation' ?     ?     0.864801  -0.502114 0.0       187.26602  0.502114  0.864801  0.0       -107.81329 0.0 
0.0       1.0 75.67258  
95  'point symmetry operation' ?     ?     0.630405  -0.776266 0.0       336.69605  0.776266  0.630405  -0.000001 -119.49453 0.0 
0.0       1.0 81.49457  
96  'point symmetry operation' ?     ?     0.313993  -0.949425 0.0       480.55035  0.949425  0.313993  0.0       -77.40216  0.0 
0.0       1.0 87.31525  
97  'point symmetry operation' ?     ?     -0.04327  -0.999063 0.0       600.11283  0.999063  -0.04327  0.0       12.99012   0.0 
0.0       1.0 93.13586  
98  'point symmetry operation' ?     ?     -0.394904 -0.918722 0.0       679.82853  0.918722  -0.394904 0.0       139.91922  0.0 
0.0       1.0 98.95719  
99  'point symmetry operation' ?     ?     -0.695161 -0.718854 -0.000001 709.32683  0.718854  -0.695161 0.0       286.87465  0.0 
0.0       1.0 104.77792 
100 'point symmetry operation' ?     ?     -0.904975 -0.425464 0.0       684.76874  0.425464  -0.904975 0.0       434.73544  0.0 
0.0       1.0 110.59876 
101 'point symmetry operation' ?     ?     -0.997053 -0.076719 0.0       609.35072  0.076719  -0.997053 0.0       564.26464  0.0 
0.0       1.0 116.42024 
102 'point symmetry operation' ?     ?     -0.959413 0.282006  0.000001  492.88376  -0.282006 -0.959413 0.0       658.61142  
0.000001  0.0       1.0 122.24069 
103 'point symmetry operation' ?     ?     -0.796952 0.604043  0.0       350.5205   -0.604043 -0.796952 0.0       705.50076  0.0 
0.0       1.0 128.06208 
104 'point symmetry operation' ?     ?     -0.530808 0.847492  0.0       200.78354  -0.847492 -0.530808 0.0       698.83204  0.0 
0.0       1.0 133.88279 
105 'point symmetry operation' ?     ?     -0.195604 0.980683  0.0       63.15131   -0.980683 -0.195604 0.0       639.47282  0.0 
0.0       1.0 139.70407 
106 'point symmetry operation' ?     ?     0.165048  0.986286  0.0       -44.46732  -0.986286 0.165048  0.0       535.14695  0.0 
0.0       1.0 145.52508 
107 'point symmetry operation' ?     ?     0.504226  0.863571  0.000001  -108.07297 -0.863571 0.504226  0.0       399.42583  0.0 
0.0       1.0 151.34563 
108 'point symmetry operation' ?     ?     0.777804  0.628506  0.0       -119.38926 -0.628506 0.777804  0.0       249.96774  0.0 
0.0       1.0 157.16697 
109 'point symmetry operation' ?     ?     0.95019   0.311671  0.0       -76.94425  -0.311671 0.95019   0.0       106.2163   0.0 
0.0       1.0 162.9878  
110 'point symmetry operation' ?     ?     0.998955  -0.045712 0.0       13.73905   0.045712  0.998955  0.0       -13.12457  0.0 
0.0       1.0 168.80883 
111 'point symmetry operation' ?     ?     0.917754  -0.397148 0.0       140.86386  0.397148  0.917754  0.0       -92.53     0.0 
0.0       1.0 174.62999 
112 'point symmetry operation' ?     ?     0.717154  -0.696915 0.0       287.88942  0.696915  0.717154  0.0       -121.66896 0.0 
0.0       1.0 180.45084 
113 'point symmetry operation' ?     ?     0.423251  -0.906012 0.0       435.68928  0.906012  0.423251  0.0       -96.74976  0.0 
0.0       1.0 186.27223 
114 'point symmetry operation' ?     ?     0.074282  -0.997237 0.0       565.03476  0.997237  0.074282  0.0       -21.01504  0.0 
0.0       1.0 192.09286 
115 'point symmetry operation' ?     ?     -0.284349 -0.958721 0.0       659.09621  0.958721  -0.284349 0.0       95.68215   0.0 
0.0       1.0 197.91438 
116 'point symmetry operation' ?     ?     -0.605989 -0.795473 0.0       705.63744  0.795473  -0.605989 0.0       238.15911  0.0 
0.0       1.0 203.73525 
117 'point symmetry operation' ?     ?     -0.848787 -0.528734 0.0       698.60349  0.528734  -0.848787 0.0       387.88006  0.0 
0.0       1.0 209.55624 
118 'point symmetry operation' ?     ?     -0.981158 -0.193207 0.0       638.90824  0.193207  -0.981158 0.0       525.36552  0.0 
0.0       1.0 215.37685 
119 'point symmetry operation' ?     ?     -0.985879 0.167457  0.0       534.31964  -0.167457 -0.985879 0.0       632.72955  0.0 
0.0       1.0 221.19781 
120 'point symmetry operation' ?     ?     -0.862337 0.506335  0.000001  398.44299  -0.506335 -0.862337 0.0       696.00277  0.0 
0.0       1.0 227.01941 
121 'point symmetry operation' ?     ?     -0.626604 0.779338  0.0       248.95788  -0.779338 -0.626604 0.0       706.95413  0.0 
0.0       1.0 232.83968 
122 'point symmetry operation' ?     ?     -0.309349 0.950949  0.0       105.31133  -0.950949 -0.309349 0.0       664.15845  0.0 
0.0       1.0 238.66144 
123 'point symmetry operation' ?     ?     0.048152  0.99884   0.0       -13.80767  -0.99884  0.048152  0.0       573.18385  0.0 
0.0       1.0 244.48217 
124 'point symmetry operation' ?     ?     0.399389  0.916782  0.000001  -92.90294  -0.916782 0.399389  0.0       445.86524  0.0 
-0.000001 1.0 250.30277 
125 'point symmetry operation' ?     ?     0.698665  0.715449  0.000001  -121.68226 -0.715449 0.698665  0.0       298.76829  0.0 
0.0       1.0 256.12386 
126 'point symmetry operation' ?     ?     0.907044  0.421036  0.000001  -96.40206  -0.421036 0.907044  0.0       151.02921  0.0 
0.0       1.0 261.94449 
127 'point symmetry operation' ?     ?     0.997416  0.071845  0.0       -20.35133  -0.071845 0.997416  0.000001  21.86995   0.0 
-0.000001 1.0 267.76621 
128 'point symmetry operation' ?     ?     0.958023  -0.286692 0.0       96.5751    0.286692  0.958023  0.0       -71.90646  0.0 
0.0       1.0 273.58679 
129 'point symmetry operation' ?     ?     0.79399   -0.607931 0.0       239.16578  0.607931  0.79399   0.0       -118.09909 0.0 
0.0       1.0 279.40835 
130 'point symmetry operation' ?     ?     0.526659  -0.850076 0.000001  388.86839  0.850076  0.526659  0.0       -110.69876 0.0 
0.000001  1.0 285.22918 
131 'point symmetry operation' ?     ?     0.190809  -0.981627 0.0       526.20816  0.981627  0.190809  0.0       -50.66852  0.0 
0.0       1.0 291.05002 
132 'point symmetry operation' ?     ?     -0.169866 -0.985467 0.0       633.31571  0.985467  -0.169866 0.0       54.18319   0.0 
0.0       1.0 296.87121 
133 'point symmetry operation' ?     ?     -0.508441 -0.861097 0.0       696.25739  0.861097  -0.508441 0.0       190.21383  0.0 
0.0       1.0 302.69198 
134 'point symmetry operation' ?     ?     -0.780867 -0.624698 0.0       706.84326  0.624698  -0.780867 0.0       339.7253   0.0 
0.0       1.0 308.51284 
135 'point symmetry operation' ?     ?     -0.951702 -0.307025 0.0       663.69692  0.307025  -0.951702 0.0       483.26685  0.0 
0.0       1.0 314.33413 
136 'point symmetry operation' ?     ?     -0.998719 0.050593  0.0       572.43092  -0.050593 -0.998719 0.0       602.16326  0.0 
0.0       1.0 320.15496 
137 'point symmetry operation' ?     ?     -0.915803 0.401628  0.0       444.92019  -0.401628 -0.915803 0.0       680.94655  0.0 
0.0       1.0 325.97634 
138 'point symmetry operation' ?     ?     -0.713739 0.700411  0.0       297.75298  -0.700411 -0.713739 0.0       709.3663   0.0 
0.0       1.0 331.79694 
139 'point symmetry operation' ?     ?     -0.418818 0.90807   0.0       150.0765   -0.90807  -0.418818 0.0       683.72559  0.0 
0.0       1.0 337.61809 
140 'point symmetry operation' ?     ?     -0.069408 0.997588  0.0       21.10317   -0.997588 -0.069408 0.0       607.35963  0.0 
0.0       1.0 343.43913 
141 'point symmetry operation' ?     ?     0.289032  0.95732   0.0       -72.38715  -0.95732  0.289032  0.0       490.20445  0.0 
0.0       1.0 349.25981 
142 'point symmetry operation' ?     ?     0.609869  0.792502  0.0       -118.23108 -0.792502 0.609869  0.0       347.50133  0.0 
0.0       1.0 355.08111 
143 'point symmetry operation' ?     ?     0.851361  0.52458   0.0       -110.46526 -0.52458  0.851361  0.0       197.81681  0.0 
0.0       1.0 360.90174 
144 'point symmetry operation' ?     ?     0.98209   0.18841   0.0       -50.09967  -0.18841  0.98209   0.0       60.62407   0.0 
0.0       1.0 366.72268 
145 'point symmetry operation' ?     ?     0.985049  -0.172273 0.0       55.0136    0.172273  0.985049  0.0       -46.22683  0.0 
0.0       1.0 372.544   
146 'point symmetry operation' ?     ?     0.859852  -0.510543 0.0       191.1974   0.510543  0.859852  0.0       -108.83545 0.0 
0.0       1.0 378.36516 
147 'point symmetry operation' ?     ?     0.622788  -0.782391 0.0       340.7342   0.782391  0.622788  0.0       -119.05659 0.0 
0.0       1.0 384.18615 
148 'point symmetry operation' ?     ?     0.304698  -0.952449 0.0       484.16963  0.952449  0.304698  0.0       -75.55902  0.0 
0.0       1.0 390.00708 
149 'point symmetry operation' ?     ?     -0.053033 -0.998593 0.000001  602.84327  0.998593  -0.053033 0.0       15.99624   0.0 
0.000001  1.0 395.82835 
150 'point symmetry operation' ?     ?     -0.403865 -0.914819 0.0       681.31469  0.914819  -0.403865 0.0       143.69926  0.0 
0.0       1.0 401.64916 
151 'point symmetry operation' ?     ?     -0.702153 -0.712026 0.0       709.37483  0.712026  -0.702153 0.0       290.93534  0.0 
0.0       1.0 407.4703  
152 'point symmetry operation' ?     ?     -0.909091 -0.416598 0.0       683.37311  0.416598  -0.909091 0.0       438.54923  0.0 
0.0       1.0 413.2907  
153 'point symmetry operation' ?     ?     -0.997755 -0.066971 0.0       606.6924   0.066971  -0.997755 0.0       567.33549  0.0 
0.0       1.0 419.11241 
154 'point symmetry operation' ?     ?     -0.95661  0.29137   0.0       489.30881  -0.29137  -0.95661  0.0       660.53924  0.0 
0.0       1.0 424.93332 
155 'point symmetry operation' ?     ?     -0.79101  0.611803  0.000001  346.49432  -0.611803 -0.79101  0.0       706.0348   0.0 
0.0       1.0 430.75398 
156 'point symmetry operation' ?     ?     -0.522499 0.85264   0.0       196.829    -0.85264  -0.522499 0.0       697.90356  0.0 
0.0       1.0 436.57523 
157 'point symmetry operation' ?     ?     -0.186009 0.982548  0.0       59.78394   -0.982548 -0.186009 0.0       637.20192  0.0 
0.0       1.0 442.3961  
158 'point symmetry operation' ?     ?     0.17468   0.984625  0.0       -46.80938  -0.984625 0.17468   0.0       531.82831  0.0 
0.0       1.0 448.217   
159 'point symmetry operation' ?     ?     0.512642  0.858602  0.0       -109.08511 -0.858602 0.512642  0.0       395.49243  0.0 
0.0       1.0 454.03816 
160 'point symmetry operation' ?     ?     0.78391   0.620874  0.000001  -118.94055 -0.620874 0.78391   0.0       245.93089  0.0 
0.0       1.0 459.85897 
161 'point symmetry operation' ?     ?     0.953191  0.30237   0.0       -75.09339  -0.30237  0.953191  0.0       102.60163  0.0 
0.0       1.0 465.6801  
162 'point symmetry operation' ?     ?     -0.160226 0.98708   0.0       50.87666   -0.98708  -0.160226 0.0       630.95738  0.0 
0.0       1.0 5.82126   
163 'point symmetry operation' ?     ?     0.200394  0.979715  0.0       -52.9227   -0.979715 0.200394  -0.000001 522.83026  
-0.000001 0.0       1.0 11.64198  
164 'point symmetry operation' ?     ?     0.534942  0.844888  0.0       -111.60822 -0.844888 0.534942  0.0       384.9108   0.0 
0.0       1.0 17.46283  
165 'point symmetry operation' ?     ?     0.799894  0.600141  0.0       -117.54513 -0.600141 0.799894  0.0       235.14165  0.0 
0.0       1.0 23.28379  
166 'point symmetry operation' ?     ?     0.960779  0.277315  0.0       -69.96096  -0.277315 0.960779  0.0       93.00981   0.0 
0.0       1.0 29.10519  
167 'point symmetry operation' ?     ?     0.996666  -0.081591 0.0       24.95412   0.081591  0.996666  -0.000001 -22.9942   0.0 
0.000001  1.0 34.92647  
168 'point symmetry operation' ?     ?     0.902886  -0.42988  0.0       154.85015  0.42988   0.902886  0.0       -97.77917  0.0 
0.0       1.0 40.74675  
169 'point symmetry operation' ?     ?     0.691639  -0.722243 0.0       302.82949  0.722243  0.691639  0.0       -121.61417 0.0 
0.0       1.0 46.56818  
170 'point symmetry operation' ?     ?     0.39041   -0.920641 0.0       449.63821  0.920641  0.39041   0.0       -91.39825  0.0 
0.0       1.0 52.38882  
171 'point symmetry operation' ?     ?     0.038387  -0.999263 0.0       576.17731  0.999263  0.038387  -0.000001 -11.06276  
0.000001  0.0       1.0 58.21017  
172 'point symmetry operation' ?     ?     -0.318628 -0.94788  0.0       665.98342  0.94788   -0.318628 0.0       108.9399   0.0 
0.0       1.0 64.03067  
173 'point symmetry operation' ?     ?     -0.634191 -0.773176 0.0       707.37296  0.773176  -0.634191 0.000001  252.99705  0.0 
0.0       1.0 69.85227  
174 'point symmetry operation' ?     ?     -0.867245 -0.497882 0.0       694.96097  0.497882  -0.867245 0.000001  402.3687   0.0 
0.0       1.0 75.67299  
175 'point symmetry operation' ?     ?     -0.987469 -0.157814 0.0       630.36311  0.157814  -0.987469 -0.000001 537.62008  0.0 
-0.000001 1.0 81.4938   
176 'point symmetry operation' ?     ?     -0.979223 0.202787  0.0       521.98244  -0.202787 -0.979223 0.0       641.15458  0.0 
0.0       1.0 87.31496  
177 'point symmetry operation' ?     ?     -0.843579 0.537006  0.0       383.91902  -0.537006 -0.843579 0.0       699.50346  0.0 
0.0       1.0 93.13612  
178 'point symmetry operation' ?     ?     -0.598185 0.801358  0.0       234.1375   -0.801358 -0.598185 0.0       705.07423  0.0 
0.0       1.0 98.95681  
179 'point symmetry operation' ?     ?     -0.274966 0.961454  0.0       92.12176   -0.961454 -0.274966 0.0       657.14253  0.0 
0.0       1.0 104.77822 
180 'point symmetry operation' ?     ?     0.084026  0.996464  0.0       -23.651    -0.996464 0.084026  0.0       561.94457  0.0 
0.0       1.0 110.59929 
181 'point symmetry operation' ?     ?     0.432086  0.901833  0.0       -98.11764  -0.901833 0.432086  0.0       431.8659   0.0 
0.0       1.0 116.42007 
182 'point symmetry operation' ?     ?     0.723931  0.689872  0.0       -121.59097 -0.689872 0.723931  0.0       283.82932  0.0 
0.0       1.0 122.24116 
183 'point symmetry operation' ?     ?     0.921593  0.388159  0.0       -91.01625  -0.388159 0.921593  0.0       137.0948   0.0 
0.0       1.0 128.06173 
184 'point symmetry operation' ?     ?     0.999354  0.035946  0.0       -10.37258  -0.035946 0.999354  0.0       10.75181   0.0 
0.0       1.0 133.88313 
185 'point symmetry operation' ?     ?     0.947098  -0.320944 0.0       109.84977  0.320944  0.947098  0.0       -78.76056  0.0 
0.0       1.0 139.70423 
186 'point symmetry operation' ?     ?     0.771624  -0.636078 0.0       254.00859  0.636078  0.771624  0.0       -119.79807 0.0 
0.0       1.0 145.52548 
187 'point symmetry operation' ?     ?     0.495762  -0.868458 0.0       403.34878  0.868458  0.495762  0.0       -107.0209  0.0 
0.0       1.0 151.34582 
188 'point symmetry operation' ?     ?     0.1554    -0.987852 0.0       538.44182  0.987852  0.1554    0.0       -42.09262  0.0 
0.0       1.0 157.16715 
189 'point symmetry operation' ?     ?     -0.20518  -0.978724 0.0       641.71127  0.978724  -0.20518  0.0       66.54094   0.0 
0.0       1.0 162.98822 
190 'point symmetry operation' ?     ?     -0.539065 -0.842264 0.0       699.72229  0.842264  -0.539065 0.0       204.74554  0.0 
0.0       1.0 168.8094  
191 'point symmetry operation' ?     ?     -0.802817 -0.596225 0.0       704.92671  0.596225  -0.802817 0.000001  354.54108  0.0 
0.000001  1.0 174.62983 
192 'point symmetry operation' ?     ?     -0.962123 -0.272617 0.0       656.6489   0.272617  -0.962123 0.0       496.43944  0.0 
0.0       1.0 180.45134 
193 'point symmetry operation' ?     ?     -0.996255 0.086461  0.0       561.16757  -0.086461 -0.996255 0.0       611.97829  0.0 
0.0       1.0 186.27238 
194 'point symmetry operation' ?     ?     -0.900774 0.434288  0.0       430.9074   -0.434288 -0.900774 0.0       686.12749  0.0 
0.0       1.0 192.09331 
195 'point symmetry operation' ?     ?     -0.688102 0.725614  0.0       282.81426  -0.725614 -0.688102 0.0       709.23876  0.0 
0.0       1.0 197.91392 
196 'point symmetry operation' ?     ?     -0.385906 0.922538  0.0       136.15461  -0.922538 -0.385906 0.0       678.30583  0.0 
0.0       1.0 203.73484 
197 'point symmetry operation' ?     ?     -0.033504 0.999439  0.0       10.00955   -0.999439 -0.033504 0.0       597.3534   0.0 
0.0       1.0 209.55584 
198 'point symmetry operation' ?     ?     0.323257  0.946311  0.0       -79.20874  -0.946311 0.323257  0.0       476.91281  0.0 
0.0       1.0 215.37654 
199 'point symmetry operation' ?     ?     0.637962  0.770068  0.0       -119.89378 -0.770068 0.637962  0.0       332.65431  0.0 
0.0       1.0 221.19768 
200 'point symmetry operation' ?     ?     0.869667  0.493638  0.0       -106.75248 -0.493638 0.869667  0.0       183.34553  0.0 
0.0       1.0 227.01863 
201 'point symmetry operation' ?     ?     0.988228  0.152986  0.0       -41.49417  -0.152986 0.988228  0.0       48.41142   0.0 
0.0       1.0 232.8398  
202 'point symmetry operation' ?     ?     0.97822   -0.20757  0.000001  67.39129   0.20757   0.97822   0.0       -54.59203  
-0.000001 0.0       1.0 238.66122 
203 'point symmetry operation' ?     ?     0.840944  -0.541122 0.0       205.73803  0.541122  0.840944  0.0       -112.26531 0.0 
0.0       1.0 244.48213 
204 'point symmetry operation' ?     ?     0.594261  -0.804272 0.0       355.54599  0.804272  0.594261  0.000001  -117.10417 
-0.000001 0.0       1.0 250.30292 
205 'point symmetry operation' ?     ?     0.270265  -0.962786 0.0       497.325    0.962786  0.270265  0.0       -68.47865  0.0 
0.0       1.0 256.12388 
206 'point symmetry operation' ?     ?     -0.088895 -0.996041 0.0       612.63067  0.996041  -0.088895 0.0       27.28345   0.0 
0.0       1.0 261.94525 
207 'point symmetry operation' ?     ?     -0.436488 -0.89971  0.0       686.46095  0.89971   -0.436488 0.0       157.72549  0.0 
0.0       1.0 267.76552 
208 'point symmetry operation' ?     ?     -0.727294 -0.686326 0.0       709.21068  0.686326  -0.727294 0.0       305.87476  0.0 
0.0       1.0 273.58744 
209 'point symmetry operation' ?     ?     -0.923478 -0.38365  0.0       677.91923  0.38365   -0.923478 0.0       452.45821  0.0 
0.0       1.0 279.40804 
210 'point symmetry operation' ?     ?     -0.999517 -0.031062 0.0       596.65903  0.031062  -0.999517 0.0       578.40459  0.0 
0.0       1.0 285.22885 
211 'point symmetry operation' ?     ?     -0.945519 0.325568  0.0       476.00101  -0.325568 -0.945519 0.0       667.329    0.0 
0.0       1.0 291.04991 
212 'point symmetry operation' ?     ?     -0.768507 0.639841  0.0       331.64388  -0.639841 -0.768507 0.0       707.66146  0.0 
0.0       1.0 296.87114 
213 'point symmetry operation' ?     ?     -0.491512 0.870871  0.0       182.36722  -0.870871 -0.491512 -0.000001 694.15525  0.0 
0.0       1.0 302.69177 
214 'point symmetry operation' ?     ?     -0.150571 0.988599  0.0       47.59306   -0.988599 -0.150571 0.0       628.56686  0.0 
0.0       1.0 308.51294 
215 'point symmetry operation' ?     ?     0.20996   0.97771   0.0       -55.14448  -0.97771  0.20996   -0.000001 519.43021  
-0.000001 0.0       1.0 314.3337  
216 'point symmetry operation' ?     ?     0.543174  0.83962   0.0       -112.47897 -0.83962  0.543174  0.0       380.94325  0.0 
0.0       1.0 320.15476 
217 'point symmetry operation' ?     ?     0.805722  0.592294  0.0       -116.95135 -0.592294 0.805722  0.0       231.1242   0.0 
0.0       1.0 325.97583 
218 'point symmetry operation' ?     ?     0.963444  0.267911  0.0       -67.9806   -0.267911 0.963444  0.0       89.46313   0.0 
0.0       1.0 331.79661 
219 'point symmetry operation' ?     ?     0.995821  -0.091328 0.0       28.06335   0.091328  0.995821  0.0       -25.60742  0.0 
0.0       1.0 337.61771 
220 'point symmetry operation' ?     ?     0.898641  -0.438685 -0.000001 158.68548  0.438685  0.898641  0.0       -99.11881  
0.000001  0.0       1.0 343.43881 
221 'point symmetry operation' ?     ?     0.684547  -0.728969 0.000001  306.88927  0.728969  0.684547  0.0       -121.50633 0.0 
0.0       1.0 349.26002 
222 'point symmetry operation' ?     ?     0.381393  -0.924413 0.0       453.39602  0.924413  0.381393  0.0       -89.85741  0.0 
0.0       1.0 355.08097 
223 'point symmetry operation' ?     ?     0.02862   -0.99959  0.0       579.14378  0.99959   0.02862   0.0       -8.28947   0.0 
0.0       1.0 360.90211 
224 'point symmetry operation' ?     ?     -0.327878 -0.94472  0.0       667.77299  0.94472   -0.327878 0.0       112.58554  0.0 
0.0       1.0 366.72288 
225 'point symmetry operation' ?     ?     -0.641717 -0.766941 0.0       707.75259  0.766941  -0.641717 0.0       257.04116  0.0 
0.0       1.0 372.544   
226 'point symmetry operation' ?     ?     -0.872069 -0.489383 0.0       693.88181  0.489383  -0.872069 0.0       406.28375  0.0 
0.0       1.0 378.36526 
227 'point symmetry operation' ?     ?     -0.988964 -0.148155 0.0       627.96455  0.148155  -0.988964 0.0       540.8977   0.0 
0.0       1.0 384.18626 
228 'point symmetry operation' ?     ?     -0.977194 0.212348  0.0       518.57662  -0.212348 -0.977194 0.0       643.36856  0.0 
0.0       1.0 390.00731 
229 'point symmetry operation' ?     ?     -0.83829  0.545225  0.0       379.94992  -0.545225 -0.83829  0.0       700.36461  0.0 
0.0       1.0 395.82807 
230 'point symmetry operation' ?     ?     -0.590324 0.807166  0.0       230.12096  -0.807166 -0.590324 0.0       704.47068  0.0 
0.0       1.0 401.64886 
231 'point symmetry operation' ?     ?     -0.265556 0.964095  0.0       88.58047   -0.964095 -0.265556 0.0       655.15377  0.0 
0.0       1.0 407.46976 
232 'point symmetry operation' ?     ?     0.093761  0.995595  0.0       -26.2558   -0.995595 0.093761  0.0       558.82895  0.0 
0.0       1.0 413.29133 
233 'point symmetry operation' ?     ?     0.440879  0.897566  0.0       -99.44731  -0.897566 0.440879  0.0       428.02808  0.0 
0.0       1.0 419.11188 
234 'point symmetry operation' ?     ?     0.730639  0.682764  0.0       -121.47312 -0.682764 0.730639  0.0       279.76992  
-0.000001 0.0       1.0 424.93332 
235 'point symmetry operation' ?     ?     0.925342  0.379133  0.0       -89.46582  -0.379133 0.925342  0.0       133.34018  0.0 
0.0       1.0 430.75428 
236 'point symmetry operation' ?     ?     0.999657  0.026177  0.0       -7.59088   -0.026177 0.999657  0.0       7.792      0.0 
0.0       1.0 436.57496 
237 'point symmetry operation' ?     ?     0.943916  -0.330185 0.0       113.50029  0.330185  0.943916  0.000001  -80.54119  0.0 
0.0       1.0 442.39554 
238 'point symmetry operation' ?     ?     0.765371  -0.643589 0.0       258.05275  0.643589  0.765371  0.0       -120.16797 0.0 
0.0       1.0 448.21705 
239 'point symmetry operation' ?     ?     0.48725   -0.873263 0.0       407.2616   0.873263  0.48725   0.0       -105.93198 
-0.000001 0.0       1.0 454.03795 
240 'point symmetry operation' ?     ?     0.145738  -0.989323 -0.000001 541.7135   0.989323  0.145738  0.0       -39.68559  0.0 
-0.000001 1.0 459.859   
241 'point symmetry operation' ?     ?     -0.214735 -0.976672 0.0       643.91583  0.976672  -0.214735 0.0       69.95175   0.0 
0.0       1.0 465.68044 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLY A 29  ? LEU A 39  ? GLY A 29  LEU A 39  1 ? 11 
HELX_P HELX_P2 AA2 TRP A 78  ? ARG A 83  ? TRP A 78  ARG A 83  1 ? 6  
HELX_P HELX_P3 AA3 ARG A 99  ? LEU A 111 ? ARG A 99  LEU A 111 1 ? 13 
HELX_P HELX_P4 AA4 SER A 135 ? LEU A 143 ? SER A 135 LEU A 143 1 ? 9  
HELX_P HELX_P5 AA5 LEU A 166 ? SER A 174 ? LEU A 166 SER A 174 1 ? 9  
HELX_P HELX_P6 AA6 ASN A 175 ? LEU A 177 ? ASN A 175 LEU A 177 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A THR 31 OG1 ? ? ? 1_555 B MG  . MG  ? ? A THR 31  A MG  201 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
metalc2 metalc ? ? A THR 48 OG1 ? ? ? 1_555 B MG  . MG  ? ? A THR 48  A MG  201 1_555 ? ? ? ? ? ? ? 1.978 ? ? 
metalc3 metalc ? ? B MG  .  MG  ? ? ? 1_555 C GSP . O2G ? ? A MG  201 A GSP 202 1_555 ? ? ? ? ? ? ? 2.149 ? ? 
metalc4 metalc ? ? B MG  .  MG  ? ? ? 1_555 C GSP . O2B ? ? A MG  201 A GSP 202 1_555 ? ? ? ? ? ? ? 1.858 ? ? 
metalc5 metalc ? ? B MG  .  MG  ? ? ? 1_555 D HOH . O   ? ? A MG  201 A HOH 301 1_555 ? ? ? ? ? ? ? 1.938 ? ? 
metalc6 metalc ? ? B MG  .  MG  ? ? ? 1_555 D HOH . O   ? ? A MG  201 A HOH 302 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OG1 ? A THR 31 ? A THR 31  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 OG1 ? A THR 48 ? A THR 48  ? 1_555 109.9 ? 
2  OG1 ? A THR 31 ? A THR 31  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O2G ? C GSP .  ? A GSP 202 ? 1_555 147.1 ? 
3  OG1 ? A THR 48 ? A THR 48  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O2G ? C GSP .  ? A GSP 202 ? 1_555 74.8  ? 
4  OG1 ? A THR 31 ? A THR 31  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O2B ? C GSP .  ? A GSP 202 ? 1_555 84.4  ? 
5  OG1 ? A THR 48 ? A THR 48  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O2B ? C GSP .  ? A GSP 202 ? 1_555 153.2 ? 
6  O2G ? C GSP .  ? A GSP 202 ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O2B ? C GSP .  ? A GSP 202 ? 1_555 81.1  ? 
7  OG1 ? A THR 31 ? A THR 31  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 301 ? 1_555 96.5  ? 
8  OG1 ? A THR 48 ? A THR 48  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 301 ? 1_555 88.3  ? 
9  O2G ? C GSP .  ? A GSP 202 ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 301 ? 1_555 116.3 ? 
10 O2B ? C GSP .  ? A GSP 202 ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 301 ? 1_555 113.1 ? 
11 OG1 ? A THR 31 ? A THR 31  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 302 ? 1_555 79.9  ? 
12 OG1 ? A THR 48 ? A THR 48  ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 302 ? 1_555 84.5  ? 
13 O2G ? C GSP .  ? A GSP 202 ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 302 ? 1_555 68.0  ? 
14 O2B ? C GSP .  ? A GSP 202 ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 302 ? 1_555 75.7  ? 
15 O   ? D HOH .  ? A HOH 301 ? 1_555 MG ? B MG . ? A MG 201 ? 1_555 O   ? D HOH .  ? A HOH 302 ? 1_555 170.3 ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   6 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 51  ? TYR A 58  ? PHE A 51  TYR A 58  
AA1 2 ILE A 61  ? VAL A 68  ? ILE A 61  VAL A 68  
AA1 3 MET A 18  ? GLY A 24  ? MET A 18  GLY A 24  
AA1 4 GLY A 87  ? ASP A 93  ? GLY A 87  ASP A 93  
AA1 5 ALA A 120 ? ASN A 126 ? ALA A 120 ASN A 126 
AA1 6 TRP A 153 ? ALA A 157 ? TRP A 153 ALA A 157 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASN A 52  ? N ASN A 52  O ASP A 67  ? O ASP A 67  
AA1 2 3 O THR A 64  ? O THR A 64  N ILE A 20  ? N ILE A 20  
AA1 3 4 N VAL A 23  ? N VAL A 23  O VAL A 91  ? O VAL A 91  
AA1 4 5 N PHE A 90  ? N PHE A 90  O LEU A 122 ? O LEU A 122 
AA1 5 6 N VAL A 123 ? N VAL A 123 O GLN A 156 ? O GLN A 156 
# 
_pdbx_entry_details.entry_id                   8S5D 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HG1 A THR 48 ? ? MG  A MG  201 ? ? 1.45 
2 1 OH  A TYR 58 ? ? OE1 A GLU 171 ? ? 1.90 
3 1 OD1 A ASP 67 ? ? O   A HOH 301 ? ? 2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 58  ? ? -172.61 128.54 
2 1 CYS A 159 ? ? -163.10 85.08  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8S5D 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      OTHER 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  2ksq 
_em_3d_fitting_list.pdb_chain_id                  A 
_em_3d_fitting_list.pdb_chain_residue_range       16-178 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      A 
_em_3d_fitting_list.chain_residue_range           16-178 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                2ksq 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    8S5D 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'FOURIER SPACE' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.79 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               27285 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               HELICAL 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            6.8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Arf1 coated membrane tubules' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_image_scans.entry_id                8S5D 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           ? 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        4096 
_em_image_scans.dimension_width         4096 
_em_image_scans.frames_per_image        ? 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   ? 
# 
_em_imaging.entry_id                        8S5D 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS GLACIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           OTHER 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            200 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             600 
_em_imaging.nominal_defocus_max             2800 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           92000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            70 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R2/1' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8S5D 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              80 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277 
_em_vitrification.instrument            'LEICA EM GP' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8S5D 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.aggregation_state       'HELICAL ARRAY' 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A GLY 2   ? A GLY 2   
3  1 Y 1 A LEU 3   ? A LEU 3   
4  1 Y 1 A PHE 4   ? A PHE 4   
5  1 Y 1 A ALA 5   ? A ALA 5   
6  1 Y 1 A SER 6   ? A SER 6   
7  1 Y 1 A LYS 7   ? A LYS 7   
8  1 Y 1 A LEU 8   ? A LEU 8   
9  1 Y 1 A PHE 9   ? A PHE 9   
10 1 Y 1 A SER 10  ? A SER 10  
11 1 Y 1 A ASN 11  ? A ASN 11  
12 1 Y 1 A LEU 12  ? A LEU 12  
13 1 Y 1 A PHE 13  ? A PHE 13  
14 1 Y 1 A GLY 14  ? A GLY 14  
15 1 Y 1 A ASN 15  ? A ASN 15  
16 1 Y 1 A ASN 179 ? A ASN 179 
17 1 Y 1 A SER 180 ? A SER 180 
18 1 Y 1 A THR 181 ? A THR 181 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CYS N      N  N N 74  
CYS CA     C  N R 75  
CYS C      C  N N 76  
CYS O      O  N N 77  
CYS CB     C  N N 78  
CYS SG     S  N N 79  
CYS OXT    O  N N 80  
CYS H      H  N N 81  
CYS H2     H  N N 82  
CYS HA     H  N N 83  
CYS HB2    H  N N 84  
CYS HB3    H  N N 85  
CYS HG     H  N N 86  
CYS HXT    H  N N 87  
GLN N      N  N N 88  
GLN CA     C  N S 89  
GLN C      C  N N 90  
GLN O      O  N N 91  
GLN CB     C  N N 92  
GLN CG     C  N N 93  
GLN CD     C  N N 94  
GLN OE1    O  N N 95  
GLN NE2    N  N N 96  
GLN OXT    O  N N 97  
GLN H      H  N N 98  
GLN H2     H  N N 99  
GLN HA     H  N N 100 
GLN HB2    H  N N 101 
GLN HB3    H  N N 102 
GLN HG2    H  N N 103 
GLN HG3    H  N N 104 
GLN HE21   H  N N 105 
GLN HE22   H  N N 106 
GLN HXT    H  N N 107 
GLU N      N  N N 108 
GLU CA     C  N S 109 
GLU C      C  N N 110 
GLU O      O  N N 111 
GLU CB     C  N N 112 
GLU CG     C  N N 113 
GLU CD     C  N N 114 
GLU OE1    O  N N 115 
GLU OE2    O  N N 116 
GLU OXT    O  N N 117 
GLU H      H  N N 118 
GLU H2     H  N N 119 
GLU HA     H  N N 120 
GLU HB2    H  N N 121 
GLU HB3    H  N N 122 
GLU HG2    H  N N 123 
GLU HG3    H  N N 124 
GLU HE2    H  N N 125 
GLU HXT    H  N N 126 
GLY N      N  N N 127 
GLY CA     C  N N 128 
GLY C      C  N N 129 
GLY O      O  N N 130 
GLY OXT    O  N N 131 
GLY H      H  N N 132 
GLY H2     H  N N 133 
GLY HA2    H  N N 134 
GLY HA3    H  N N 135 
GLY HXT    H  N N 136 
GSP PG     P  N N 137 
GSP O3B    O  N N 138 
GSP S1G    S  N N 139 
GSP O2G    O  N N 140 
GSP O3G    O  N N 141 
GSP PB     P  N S 142 
GSP O1B    O  N N 143 
GSP O2B    O  N N 144 
GSP PA     P  N S 145 
GSP O1A    O  N N 146 
GSP O2A    O  N N 147 
GSP O3A    O  N N 148 
GSP "O5'"  O  N N 149 
GSP "C5'"  C  N N 150 
GSP "C4'"  C  N R 151 
GSP "O4'"  O  N N 152 
GSP "C3'"  C  N S 153 
GSP "O3'"  O  N N 154 
GSP "C2'"  C  N R 155 
GSP "O2'"  O  N N 156 
GSP "C1'"  C  N R 157 
GSP N9     N  Y N 158 
GSP C8     C  Y N 159 
GSP N7     N  Y N 160 
GSP C5     C  Y N 161 
GSP C6     C  N N 162 
GSP O6     O  N N 163 
GSP N1     N  N N 164 
GSP C2     C  N N 165 
GSP N2     N  N N 166 
GSP N3     N  N N 167 
GSP C4     C  Y N 168 
GSP HOG2   H  N N 169 
GSP HOG3   H  N N 170 
GSP HOB2   H  N N 171 
GSP HOA2   H  N N 172 
GSP "H5'1" H  N N 173 
GSP "H5'2" H  N N 174 
GSP "H4'"  H  N N 175 
GSP "H3'"  H  N N 176 
GSP "HO3'" H  N N 177 
GSP "H2'"  H  N N 178 
GSP "HO2'" H  N N 179 
GSP "H1'"  H  N N 180 
GSP H8     H  N N 181 
GSP HN1    H  N N 182 
GSP HN21   H  N N 183 
GSP HN22   H  N N 184 
HIS N      N  N N 185 
HIS CA     C  N S 186 
HIS C      C  N N 187 
HIS O      O  N N 188 
HIS CB     C  N N 189 
HIS CG     C  Y N 190 
HIS ND1    N  Y N 191 
HIS CD2    C  Y N 192 
HIS CE1    C  Y N 193 
HIS NE2    N  Y N 194 
HIS OXT    O  N N 195 
HIS H      H  N N 196 
HIS H2     H  N N 197 
HIS HA     H  N N 198 
HIS HB2    H  N N 199 
HIS HB3    H  N N 200 
HIS HD1    H  N N 201 
HIS HD2    H  N N 202 
HIS HE1    H  N N 203 
HIS HE2    H  N N 204 
HIS HXT    H  N N 205 
HOH O      O  N N 206 
HOH H1     H  N N 207 
HOH H2     H  N N 208 
ILE N      N  N N 209 
ILE CA     C  N S 210 
ILE C      C  N N 211 
ILE O      O  N N 212 
ILE CB     C  N S 213 
ILE CG1    C  N N 214 
ILE CG2    C  N N 215 
ILE CD1    C  N N 216 
ILE OXT    O  N N 217 
ILE H      H  N N 218 
ILE H2     H  N N 219 
ILE HA     H  N N 220 
ILE HB     H  N N 221 
ILE HG12   H  N N 222 
ILE HG13   H  N N 223 
ILE HG21   H  N N 224 
ILE HG22   H  N N 225 
ILE HG23   H  N N 226 
ILE HD11   H  N N 227 
ILE HD12   H  N N 228 
ILE HD13   H  N N 229 
ILE HXT    H  N N 230 
LEU N      N  N N 231 
LEU CA     C  N S 232 
LEU C      C  N N 233 
LEU O      O  N N 234 
LEU CB     C  N N 235 
LEU CG     C  N N 236 
LEU CD1    C  N N 237 
LEU CD2    C  N N 238 
LEU OXT    O  N N 239 
LEU H      H  N N 240 
LEU H2     H  N N 241 
LEU HA     H  N N 242 
LEU HB2    H  N N 243 
LEU HB3    H  N N 244 
LEU HG     H  N N 245 
LEU HD11   H  N N 246 
LEU HD12   H  N N 247 
LEU HD13   H  N N 248 
LEU HD21   H  N N 249 
LEU HD22   H  N N 250 
LEU HD23   H  N N 251 
LEU HXT    H  N N 252 
LYS N      N  N N 253 
LYS CA     C  N S 254 
LYS C      C  N N 255 
LYS O      O  N N 256 
LYS CB     C  N N 257 
LYS CG     C  N N 258 
LYS CD     C  N N 259 
LYS CE     C  N N 260 
LYS NZ     N  N N 261 
LYS OXT    O  N N 262 
LYS H      H  N N 263 
LYS H2     H  N N 264 
LYS HA     H  N N 265 
LYS HB2    H  N N 266 
LYS HB3    H  N N 267 
LYS HG2    H  N N 268 
LYS HG3    H  N N 269 
LYS HD2    H  N N 270 
LYS HD3    H  N N 271 
LYS HE2    H  N N 272 
LYS HE3    H  N N 273 
LYS HZ1    H  N N 274 
LYS HZ2    H  N N 275 
LYS HZ3    H  N N 276 
LYS HXT    H  N N 277 
MET N      N  N N 278 
MET CA     C  N S 279 
MET C      C  N N 280 
MET O      O  N N 281 
MET CB     C  N N 282 
MET CG     C  N N 283 
MET SD     S  N N 284 
MET CE     C  N N 285 
MET OXT    O  N N 286 
MET H      H  N N 287 
MET H2     H  N N 288 
MET HA     H  N N 289 
MET HB2    H  N N 290 
MET HB3    H  N N 291 
MET HG2    H  N N 292 
MET HG3    H  N N 293 
MET HE1    H  N N 294 
MET HE2    H  N N 295 
MET HE3    H  N N 296 
MET HXT    H  N N 297 
MG  MG     MG N N 298 
PHE N      N  N N 299 
PHE CA     C  N S 300 
PHE C      C  N N 301 
PHE O      O  N N 302 
PHE CB     C  N N 303 
PHE CG     C  Y N 304 
PHE CD1    C  Y N 305 
PHE CD2    C  Y N 306 
PHE CE1    C  Y N 307 
PHE CE2    C  Y N 308 
PHE CZ     C  Y N 309 
PHE OXT    O  N N 310 
PHE H      H  N N 311 
PHE H2     H  N N 312 
PHE HA     H  N N 313 
PHE HB2    H  N N 314 
PHE HB3    H  N N 315 
PHE HD1    H  N N 316 
PHE HD2    H  N N 317 
PHE HE1    H  N N 318 
PHE HE2    H  N N 319 
PHE HZ     H  N N 320 
PHE HXT    H  N N 321 
PRO N      N  N N 322 
PRO CA     C  N S 323 
PRO C      C  N N 324 
PRO O      O  N N 325 
PRO CB     C  N N 326 
PRO CG     C  N N 327 
PRO CD     C  N N 328 
PRO OXT    O  N N 329 
PRO H      H  N N 330 
PRO HA     H  N N 331 
PRO HB2    H  N N 332 
PRO HB3    H  N N 333 
PRO HG2    H  N N 334 
PRO HG3    H  N N 335 
PRO HD2    H  N N 336 
PRO HD3    H  N N 337 
PRO HXT    H  N N 338 
SER N      N  N N 339 
SER CA     C  N S 340 
SER C      C  N N 341 
SER O      O  N N 342 
SER CB     C  N N 343 
SER OG     O  N N 344 
SER OXT    O  N N 345 
SER H      H  N N 346 
SER H2     H  N N 347 
SER HA     H  N N 348 
SER HB2    H  N N 349 
SER HB3    H  N N 350 
SER HG     H  N N 351 
SER HXT    H  N N 352 
THR N      N  N N 353 
THR CA     C  N S 354 
THR C      C  N N 355 
THR O      O  N N 356 
THR CB     C  N R 357 
THR OG1    O  N N 358 
THR CG2    C  N N 359 
THR OXT    O  N N 360 
THR H      H  N N 361 
THR H2     H  N N 362 
THR HA     H  N N 363 
THR HB     H  N N 364 
THR HG1    H  N N 365 
THR HG21   H  N N 366 
THR HG22   H  N N 367 
THR HG23   H  N N 368 
THR HXT    H  N N 369 
TRP N      N  N N 370 
TRP CA     C  N S 371 
TRP C      C  N N 372 
TRP O      O  N N 373 
TRP CB     C  N N 374 
TRP CG     C  Y N 375 
TRP CD1    C  Y N 376 
TRP CD2    C  Y N 377 
TRP NE1    N  Y N 378 
TRP CE2    C  Y N 379 
TRP CE3    C  Y N 380 
TRP CZ2    C  Y N 381 
TRP CZ3    C  Y N 382 
TRP CH2    C  Y N 383 
TRP OXT    O  N N 384 
TRP H      H  N N 385 
TRP H2     H  N N 386 
TRP HA     H  N N 387 
TRP HB2    H  N N 388 
TRP HB3    H  N N 389 
TRP HD1    H  N N 390 
TRP HE1    H  N N 391 
TRP HE3    H  N N 392 
TRP HZ2    H  N N 393 
TRP HZ3    H  N N 394 
TRP HH2    H  N N 395 
TRP HXT    H  N N 396 
TYR N      N  N N 397 
TYR CA     C  N S 398 
TYR C      C  N N 399 
TYR O      O  N N 400 
TYR CB     C  N N 401 
TYR CG     C  Y N 402 
TYR CD1    C  Y N 403 
TYR CD2    C  Y N 404 
TYR CE1    C  Y N 405 
TYR CE2    C  Y N 406 
TYR CZ     C  Y N 407 
TYR OH     O  N N 408 
TYR OXT    O  N N 409 
TYR H      H  N N 410 
TYR H2     H  N N 411 
TYR HA     H  N N 412 
TYR HB2    H  N N 413 
TYR HB3    H  N N 414 
TYR HD1    H  N N 415 
TYR HD2    H  N N 416 
TYR HE1    H  N N 417 
TYR HE2    H  N N 418 
TYR HH     H  N N 419 
TYR HXT    H  N N 420 
VAL N      N  N N 421 
VAL CA     C  N S 422 
VAL C      C  N N 423 
VAL O      O  N N 424 
VAL CB     C  N N 425 
VAL CG1    C  N N 426 
VAL CG2    C  N N 427 
VAL OXT    O  N N 428 
VAL H      H  N N 429 
VAL H2     H  N N 430 
VAL HA     H  N N 431 
VAL HB     H  N N 432 
VAL HG11   H  N N 433 
VAL HG12   H  N N 434 
VAL HG13   H  N N 435 
VAL HG21   H  N N 436 
VAL HG22   H  N N 437 
VAL HG23   H  N N 438 
VAL HXT    H  N N 439 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
GLN N     CA     sing N N 83  
GLN N     H      sing N N 84  
GLN N     H2     sing N N 85  
GLN CA    C      sing N N 86  
GLN CA    CB     sing N N 87  
GLN CA    HA     sing N N 88  
GLN C     O      doub N N 89  
GLN C     OXT    sing N N 90  
GLN CB    CG     sing N N 91  
GLN CB    HB2    sing N N 92  
GLN CB    HB3    sing N N 93  
GLN CG    CD     sing N N 94  
GLN CG    HG2    sing N N 95  
GLN CG    HG3    sing N N 96  
GLN CD    OE1    doub N N 97  
GLN CD    NE2    sing N N 98  
GLN NE2   HE21   sing N N 99  
GLN NE2   HE22   sing N N 100 
GLN OXT   HXT    sing N N 101 
GLU N     CA     sing N N 102 
GLU N     H      sing N N 103 
GLU N     H2     sing N N 104 
GLU CA    C      sing N N 105 
GLU CA    CB     sing N N 106 
GLU CA    HA     sing N N 107 
GLU C     O      doub N N 108 
GLU C     OXT    sing N N 109 
GLU CB    CG     sing N N 110 
GLU CB    HB2    sing N N 111 
GLU CB    HB3    sing N N 112 
GLU CG    CD     sing N N 113 
GLU CG    HG2    sing N N 114 
GLU CG    HG3    sing N N 115 
GLU CD    OE1    doub N N 116 
GLU CD    OE2    sing N N 117 
GLU OE2   HE2    sing N N 118 
GLU OXT   HXT    sing N N 119 
GLY N     CA     sing N N 120 
GLY N     H      sing N N 121 
GLY N     H2     sing N N 122 
GLY CA    C      sing N N 123 
GLY CA    HA2    sing N N 124 
GLY CA    HA3    sing N N 125 
GLY C     O      doub N N 126 
GLY C     OXT    sing N N 127 
GLY OXT   HXT    sing N N 128 
GSP PG    O3B    sing N N 129 
GSP PG    S1G    doub N N 130 
GSP PG    O2G    sing N N 131 
GSP PG    O3G    sing N N 132 
GSP O3B   PB     sing N N 133 
GSP O2G   HOG2   sing N N 134 
GSP O3G   HOG3   sing N N 135 
GSP PB    O1B    doub N N 136 
GSP PB    O2B    sing N N 137 
GSP PB    O3A    sing N N 138 
GSP O2B   HOB2   sing N N 139 
GSP PA    O1A    doub N N 140 
GSP PA    O2A    sing N N 141 
GSP PA    O3A    sing N N 142 
GSP PA    "O5'"  sing N N 143 
GSP O2A   HOA2   sing N N 144 
GSP "O5'" "C5'"  sing N N 145 
GSP "C5'" "C4'"  sing N N 146 
GSP "C5'" "H5'1" sing N N 147 
GSP "C5'" "H5'2" sing N N 148 
GSP "C4'" "O4'"  sing N N 149 
GSP "C4'" "C3'"  sing N N 150 
GSP "C4'" "H4'"  sing N N 151 
GSP "O4'" "C1'"  sing N N 152 
GSP "C3'" "O3'"  sing N N 153 
GSP "C3'" "C2'"  sing N N 154 
GSP "C3'" "H3'"  sing N N 155 
GSP "O3'" "HO3'" sing N N 156 
GSP "C2'" "O2'"  sing N N 157 
GSP "C2'" "C1'"  sing N N 158 
GSP "C2'" "H2'"  sing N N 159 
GSP "O2'" "HO2'" sing N N 160 
GSP "C1'" N9     sing N N 161 
GSP "C1'" "H1'"  sing N N 162 
GSP N9    C8     sing Y N 163 
GSP N9    C4     sing Y N 164 
GSP C8    N7     doub Y N 165 
GSP C8    H8     sing N N 166 
GSP N7    C5     sing Y N 167 
GSP C5    C6     sing N N 168 
GSP C5    C4     doub Y N 169 
GSP C6    O6     doub N N 170 
GSP C6    N1     sing N N 171 
GSP N1    C2     sing N N 172 
GSP N1    HN1    sing N N 173 
GSP C2    N2     sing N N 174 
GSP C2    N3     doub N N 175 
GSP N2    HN21   sing N N 176 
GSP N2    HN22   sing N N 177 
GSP N3    C4     sing N N 178 
HIS N     CA     sing N N 179 
HIS N     H      sing N N 180 
HIS N     H2     sing N N 181 
HIS CA    C      sing N N 182 
HIS CA    CB     sing N N 183 
HIS CA    HA     sing N N 184 
HIS C     O      doub N N 185 
HIS C     OXT    sing N N 186 
HIS CB    CG     sing N N 187 
HIS CB    HB2    sing N N 188 
HIS CB    HB3    sing N N 189 
HIS CG    ND1    sing Y N 190 
HIS CG    CD2    doub Y N 191 
HIS ND1   CE1    doub Y N 192 
HIS ND1   HD1    sing N N 193 
HIS CD2   NE2    sing Y N 194 
HIS CD2   HD2    sing N N 195 
HIS CE1   NE2    sing Y N 196 
HIS CE1   HE1    sing N N 197 
HIS NE2   HE2    sing N N 198 
HIS OXT   HXT    sing N N 199 
HOH O     H1     sing N N 200 
HOH O     H2     sing N N 201 
ILE N     CA     sing N N 202 
ILE N     H      sing N N 203 
ILE N     H2     sing N N 204 
ILE CA    C      sing N N 205 
ILE CA    CB     sing N N 206 
ILE CA    HA     sing N N 207 
ILE C     O      doub N N 208 
ILE C     OXT    sing N N 209 
ILE CB    CG1    sing N N 210 
ILE CB    CG2    sing N N 211 
ILE CB    HB     sing N N 212 
ILE CG1   CD1    sing N N 213 
ILE CG1   HG12   sing N N 214 
ILE CG1   HG13   sing N N 215 
ILE CG2   HG21   sing N N 216 
ILE CG2   HG22   sing N N 217 
ILE CG2   HG23   sing N N 218 
ILE CD1   HD11   sing N N 219 
ILE CD1   HD12   sing N N 220 
ILE CD1   HD13   sing N N 221 
ILE OXT   HXT    sing N N 222 
LEU N     CA     sing N N 223 
LEU N     H      sing N N 224 
LEU N     H2     sing N N 225 
LEU CA    C      sing N N 226 
LEU CA    CB     sing N N 227 
LEU CA    HA     sing N N 228 
LEU C     O      doub N N 229 
LEU C     OXT    sing N N 230 
LEU CB    CG     sing N N 231 
LEU CB    HB2    sing N N 232 
LEU CB    HB3    sing N N 233 
LEU CG    CD1    sing N N 234 
LEU CG    CD2    sing N N 235 
LEU CG    HG     sing N N 236 
LEU CD1   HD11   sing N N 237 
LEU CD1   HD12   sing N N 238 
LEU CD1   HD13   sing N N 239 
LEU CD2   HD21   sing N N 240 
LEU CD2   HD22   sing N N 241 
LEU CD2   HD23   sing N N 242 
LEU OXT   HXT    sing N N 243 
LYS N     CA     sing N N 244 
LYS N     H      sing N N 245 
LYS N     H2     sing N N 246 
LYS CA    C      sing N N 247 
LYS CA    CB     sing N N 248 
LYS CA    HA     sing N N 249 
LYS C     O      doub N N 250 
LYS C     OXT    sing N N 251 
LYS CB    CG     sing N N 252 
LYS CB    HB2    sing N N 253 
LYS CB    HB3    sing N N 254 
LYS CG    CD     sing N N 255 
LYS CG    HG2    sing N N 256 
LYS CG    HG3    sing N N 257 
LYS CD    CE     sing N N 258 
LYS CD    HD2    sing N N 259 
LYS CD    HD3    sing N N 260 
LYS CE    NZ     sing N N 261 
LYS CE    HE2    sing N N 262 
LYS CE    HE3    sing N N 263 
LYS NZ    HZ1    sing N N 264 
LYS NZ    HZ2    sing N N 265 
LYS NZ    HZ3    sing N N 266 
LYS OXT   HXT    sing N N 267 
MET N     CA     sing N N 268 
MET N     H      sing N N 269 
MET N     H2     sing N N 270 
MET CA    C      sing N N 271 
MET CA    CB     sing N N 272 
MET CA    HA     sing N N 273 
MET C     O      doub N N 274 
MET C     OXT    sing N N 275 
MET CB    CG     sing N N 276 
MET CB    HB2    sing N N 277 
MET CB    HB3    sing N N 278 
MET CG    SD     sing N N 279 
MET CG    HG2    sing N N 280 
MET CG    HG3    sing N N 281 
MET SD    CE     sing N N 282 
MET CE    HE1    sing N N 283 
MET CE    HE2    sing N N 284 
MET CE    HE3    sing N N 285 
MET OXT   HXT    sing N N 286 
PHE N     CA     sing N N 287 
PHE N     H      sing N N 288 
PHE N     H2     sing N N 289 
PHE CA    C      sing N N 290 
PHE CA    CB     sing N N 291 
PHE CA    HA     sing N N 292 
PHE C     O      doub N N 293 
PHE C     OXT    sing N N 294 
PHE CB    CG     sing N N 295 
PHE CB    HB2    sing N N 296 
PHE CB    HB3    sing N N 297 
PHE CG    CD1    doub Y N 298 
PHE CG    CD2    sing Y N 299 
PHE CD1   CE1    sing Y N 300 
PHE CD1   HD1    sing N N 301 
PHE CD2   CE2    doub Y N 302 
PHE CD2   HD2    sing N N 303 
PHE CE1   CZ     doub Y N 304 
PHE CE1   HE1    sing N N 305 
PHE CE2   CZ     sing Y N 306 
PHE CE2   HE2    sing N N 307 
PHE CZ    HZ     sing N N 308 
PHE OXT   HXT    sing N N 309 
PRO N     CA     sing N N 310 
PRO N     CD     sing N N 311 
PRO N     H      sing N N 312 
PRO CA    C      sing N N 313 
PRO CA    CB     sing N N 314 
PRO CA    HA     sing N N 315 
PRO C     O      doub N N 316 
PRO C     OXT    sing N N 317 
PRO CB    CG     sing N N 318 
PRO CB    HB2    sing N N 319 
PRO CB    HB3    sing N N 320 
PRO CG    CD     sing N N 321 
PRO CG    HG2    sing N N 322 
PRO CG    HG3    sing N N 323 
PRO CD    HD2    sing N N 324 
PRO CD    HD3    sing N N 325 
PRO OXT   HXT    sing N N 326 
SER N     CA     sing N N 327 
SER N     H      sing N N 328 
SER N     H2     sing N N 329 
SER CA    C      sing N N 330 
SER CA    CB     sing N N 331 
SER CA    HA     sing N N 332 
SER C     O      doub N N 333 
SER C     OXT    sing N N 334 
SER CB    OG     sing N N 335 
SER CB    HB2    sing N N 336 
SER CB    HB3    sing N N 337 
SER OG    HG     sing N N 338 
SER OXT   HXT    sing N N 339 
THR N     CA     sing N N 340 
THR N     H      sing N N 341 
THR N     H2     sing N N 342 
THR CA    C      sing N N 343 
THR CA    CB     sing N N 344 
THR CA    HA     sing N N 345 
THR C     O      doub N N 346 
THR C     OXT    sing N N 347 
THR CB    OG1    sing N N 348 
THR CB    CG2    sing N N 349 
THR CB    HB     sing N N 350 
THR OG1   HG1    sing N N 351 
THR CG2   HG21   sing N N 352 
THR CG2   HG22   sing N N 353 
THR CG2   HG23   sing N N 354 
THR OXT   HXT    sing N N 355 
TRP N     CA     sing N N 356 
TRP N     H      sing N N 357 
TRP N     H2     sing N N 358 
TRP CA    C      sing N N 359 
TRP CA    CB     sing N N 360 
TRP CA    HA     sing N N 361 
TRP C     O      doub N N 362 
TRP C     OXT    sing N N 363 
TRP CB    CG     sing N N 364 
TRP CB    HB2    sing N N 365 
TRP CB    HB3    sing N N 366 
TRP CG    CD1    doub Y N 367 
TRP CG    CD2    sing Y N 368 
TRP CD1   NE1    sing Y N 369 
TRP CD1   HD1    sing N N 370 
TRP CD2   CE2    doub Y N 371 
TRP CD2   CE3    sing Y N 372 
TRP NE1   CE2    sing Y N 373 
TRP NE1   HE1    sing N N 374 
TRP CE2   CZ2    sing Y N 375 
TRP CE3   CZ3    doub Y N 376 
TRP CE3   HE3    sing N N 377 
TRP CZ2   CH2    doub Y N 378 
TRP CZ2   HZ2    sing N N 379 
TRP CZ3   CH2    sing Y N 380 
TRP CZ3   HZ3    sing N N 381 
TRP CH2   HH2    sing N N 382 
TRP OXT   HXT    sing N N 383 
TYR N     CA     sing N N 384 
TYR N     H      sing N N 385 
TYR N     H2     sing N N 386 
TYR CA    C      sing N N 387 
TYR CA    CB     sing N N 388 
TYR CA    HA     sing N N 389 
TYR C     O      doub N N 390 
TYR C     OXT    sing N N 391 
TYR CB    CG     sing N N 392 
TYR CB    HB2    sing N N 393 
TYR CB    HB3    sing N N 394 
TYR CG    CD1    doub Y N 395 
TYR CG    CD2    sing Y N 396 
TYR CD1   CE1    sing Y N 397 
TYR CD1   HD1    sing N N 398 
TYR CD2   CE2    doub Y N 399 
TYR CD2   HD2    sing N N 400 
TYR CE1   CZ     doub Y N 401 
TYR CE1   HE1    sing N N 402 
TYR CE2   CZ     sing Y N 403 
TYR CE2   HE2    sing N N 404 
TYR CZ    OH     sing N N 405 
TYR OH    HH     sing N N 406 
TYR OXT   HXT    sing N N 407 
VAL N     CA     sing N N 408 
VAL N     H      sing N N 409 
VAL N     H2     sing N N 410 
VAL CA    C      sing N N 411 
VAL CA    CB     sing N N 412 
VAL CA    HA     sing N N 413 
VAL C     O      doub N N 414 
VAL C     OXT    sing N N 415 
VAL CB    CG1    sing N N 416 
VAL CB    CG2    sing N N 417 
VAL CB    HB     sing N N 418 
VAL CG1   HG11   sing N N 419 
VAL CG1   HG12   sing N N 420 
VAL CG1   HG13   sing N N 421 
VAL CG2   HG21   sing N N 422 
VAL CG2   HG22   sing N N 423 
VAL CG2   HG23   sing N N 424 
VAL OXT   HXT    sing N N 425 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-02-23 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           8S5D 
_em_admin.last_update        2025-01-22 
_em_admin.map_release_date   2025-01-22 
_em_admin.title              'Cryo-EM structure of Arf1-decorated membrane tubules' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 20  mM HEPES 1 HEPES                
1 50  mM KAc   2 'potassium acetate'  
1 1.2 mM MgCl2 3 'magnesium chloride' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          4932 
_em_entity_assembly_naturalsource.organism             'Saccharomyces cerevisiae' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.details                        ? 
_em_helical_entity.axial_symmetry                 C3 
_em_helical_entity.angular_rotation_per_subunit   20.78 
_em_helical_entity.axial_rise_per_subunit         5.821 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         21 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     12483 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   1489051 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? cryoSPARC 'v4.3.1, v4.4.2' 
'IMAGE ACQUISITION'             ? 2  ? ? 1 EPU       2.2.0.65REL      
MASKING                         ? 3  ? ? ? ?         ?                
'CTF CORRECTION'                ? 4  1 ? ? cryoSPARC 'v4.3.1, v4.4.2' 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?                
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?                
'MODEL FITTING'                 ? 7  ? 1 ? ISOLDE    ?                
OTHER                           ? 8  ? ? ? ?         ?                
'MODEL REFINEMENT'              ? 9  ? 1 ? PHENIX    1.21-5187        
'MODEL REFINEMENT'              ? 10 ? 1 ? Coot      '0.9.7 EL'       
'INITIAL EULER ASSIGNMENT'      ? 11 1 ? ? ?         ?                
'FINAL EULER ASSIGNMENT'        ? 12 1 ? ? ?         ?                
CLASSIFICATION                  ? 13 1 ? ? cryoSPARC 'v4.3.1, v4.4.2' 
RECONSTRUCTION                  ? 14 1 ? ? cryoSPARC 'v4.3.1, v4.4.2' 
'VOLUME SELECTION'              ? 15 1 1 1 ?         ?                
'SERIES ALIGNMENT'              ? 16 1 1 1 ?         ?                
'MOLECULAR REPLACEMENT'         ? 17 1 1 1 ?         ?                
'LATTICE DISTORTION CORRECTION' ? 18 1 1 1 ?         ?                
'SYMMETRY DETERMINATION'        ? 19 1 1 1 ?         ?                
'CRYSTALLOGRAPHY MERGING'       ? 20 1 1 1 ?         ?                
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'German Federal Ministry for Education and Research' Germany 03Z22HN23 1 
'German Federal Ministry for Education and Research' Germany 03Z22HI2  2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2ksq 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8S5D 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
H  
MG 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N      . LYS A 1 16  ? 316.614 220.719 100.754 1.00 56.69 ? 16  LYS A N      1 
ATOM   2    C  CA     . LYS A 1 16  ? 315.504 221.233 101.531 1.00 60.61 ? 16  LYS A CA     1 
ATOM   3    C  C      . LYS A 1 16  ? 314.214 220.557 101.097 1.00 62.64 ? 16  LYS A C      1 
ATOM   4    O  O      . LYS A 1 16  ? 313.324 220.322 101.908 1.00 64.36 ? 16  LYS A O      1 
ATOM   5    C  CB     . LYS A 1 16  ? 315.404 222.747 101.359 1.00 65.35 ? 16  LYS A CB     1 
ATOM   6    C  CG     . LYS A 1 16  ? 314.289 223.417 102.150 1.00 67.56 ? 16  LYS A CG     1 
ATOM   7    C  CD     . LYS A 1 16  ? 314.475 223.260 103.647 1.00 67.25 ? 16  LYS A CD     1 
ATOM   8    C  CE     . LYS A 1 16  ? 313.286 223.814 104.408 1.00 70.34 ? 16  LYS A CE     1 
ATOM   9    N  NZ     . LYS A 1 16  ? 312.022 223.123 104.035 1.00 76.39 ? 16  LYS A NZ     1 
ATOM   10   H  H      . LYS A 1 16  ? 317.313 221.218 100.781 1.00 58.71 ? 16  LYS A H      1 
ATOM   11   H  HA     . LYS A 1 16  ? 315.654 221.037 102.467 1.00 61.29 ? 16  LYS A HA     1 
ATOM   12   H  HB2    . LYS A 1 16  ? 316.242 223.135 101.647 1.00 64.92 ? 16  LYS A HB2    1 
ATOM   13   H  HB3    . LYS A 1 16  ? 315.261 222.939 100.420 1.00 64.08 ? 16  LYS A HB3    1 
ATOM   14   H  HG2    . LYS A 1 16  ? 314.283 224.365 101.949 1.00 65.97 ? 16  LYS A HG2    1 
ATOM   15   H  HG3    . LYS A 1 16  ? 313.441 223.022 101.904 1.00 66.44 ? 16  LYS A HG3    1 
ATOM   16   H  HD2    . LYS A 1 16  ? 314.561 222.320 103.865 1.00 66.06 ? 16  LYS A HD2    1 
ATOM   17   H  HD3    . LYS A 1 16  ? 315.265 223.747 103.925 1.00 65.77 ? 16  LYS A HD3    1 
ATOM   18   H  HE2    . LYS A 1 16  ? 313.432 223.687 105.359 1.00 68.89 ? 16  LYS A HE2    1 
ATOM   19   H  HE3    . LYS A 1 16  ? 313.191 224.757 104.205 1.00 68.34 ? 16  LYS A HE3    1 
ATOM   20   H  HZ1    . LYS A 1 16  ? 311.831 223.279 103.180 1.00 72.27 ? 16  LYS A HZ1    1 
ATOM   21   H  HZ2    . LYS A 1 16  ? 311.350 223.417 104.539 1.00 75.32 ? 16  LYS A HZ2    1 
ATOM   22   H  HZ3    . LYS A 1 16  ? 312.112 222.246 104.155 1.00 72.89 ? 16  LYS A HZ3    1 
ATOM   23   N  N      . GLU A 1 17  ? 314.125 220.236 99.809  1.00 58.72 ? 17  GLU A N      1 
ATOM   24   C  CA     . GLU A 1 17  ? 312.970 219.540 99.267  1.00 55.47 ? 17  GLU A CA     1 
ATOM   25   C  C      . GLU A 1 17  ? 313.401 218.722 98.063  1.00 55.09 ? 17  GLU A C      1 
ATOM   26   O  O      . GLU A 1 17  ? 314.429 218.990 97.438  1.00 55.93 ? 17  GLU A O      1 
ATOM   27   C  CB     . GLU A 1 17  ? 311.858 220.507 98.862  1.00 59.75 ? 17  GLU A CB     1 
ATOM   28   C  CG     . GLU A 1 17  ? 311.127 221.138 100.022 1.00 67.59 ? 17  GLU A CG     1 
ATOM   29   C  CD     . GLU A 1 17  ? 310.117 222.174 99.572  1.00 78.52 ? 17  GLU A CD     1 
ATOM   30   O  OE1    . GLU A 1 17  ? 308.903 221.888 99.630  1.00 79.23 ? 17  GLU A OE1    1 
ATOM   31   O  OE2    . GLU A 1 17  ? 310.537 223.274 99.157  1.00 87.08 ? 17  GLU A OE2    1 
ATOM   32   H  H      . GLU A 1 17  ? 314.726 220.412 99.226  1.00 59.47 ? 17  GLU A H      1 
ATOM   33   H  HA     . GLU A 1 17  ? 312.616 218.937 99.933  1.00 59.75 ? 17  GLU A HA     1 
ATOM   34   H  HB2    . GLU A 1 17  ? 312.250 221.217 98.334  1.00 63.15 ? 17  GLU A HB2    1 
ATOM   35   H  HB3    . GLU A 1 17  ? 311.212 220.018 98.332  1.00 62.22 ? 17  GLU A HB3    1 
ATOM   36   H  HG2    . GLU A 1 17  ? 310.657 220.450 100.513 1.00 68.37 ? 17  GLU A HG2    1 
ATOM   37   H  HG3    . GLU A 1 17  ? 311.774 221.577 100.597 1.00 66.95 ? 17  GLU A HG3    1 
ATOM   38   N  N      . MET A 1 18  ? 312.592 217.719 97.741  1.00 52.73 ? 18  MET A N      1 
ATOM   39   C  CA     . MET A 1 18  ? 312.873 216.847 96.615  1.00 47.19 ? 18  MET A CA     1 
ATOM   40   C  C      . MET A 1 18  ? 311.637 216.010 96.345  1.00 46.24 ? 18  MET A C      1 
ATOM   41   O  O      . MET A 1 18  ? 310.945 215.609 97.281  1.00 48.30 ? 18  MET A O      1 
ATOM   42   C  CB     . MET A 1 18  ? 314.069 215.943 96.890  1.00 45.93 ? 18  MET A CB     1 
ATOM   43   C  CG     . MET A 1 18  ? 314.796 215.514 95.649  1.00 47.70 ? 18  MET A CG     1 
ATOM   44   S  SD     . MET A 1 18  ? 316.272 214.560 95.980  1.00 55.16 ? 18  MET A SD     1 
ATOM   45   C  CE     . MET A 1 18  ? 316.737 214.219 94.298  1.00 40.12 ? 18  MET A CE     1 
ATOM   46   H  H      . MET A 1 18  ? 311.876 217.520 98.167  1.00 53.29 ? 18  MET A H      1 
ATOM   47   H  HA     . MET A 1 18  ? 313.073 217.380 95.836  1.00 48.67 ? 18  MET A HA     1 
ATOM   48   H  HB2    . MET A 1 18  ? 314.695 216.417 97.455  1.00 48.58 ? 18  MET A HB2    1 
ATOM   49   H  HB3    . MET A 1 18  ? 313.745 215.147 97.330  1.00 47.56 ? 18  MET A HB3    1 
ATOM   50   H  HG2    . MET A 1 18  ? 314.213 214.960 95.115  1.00 47.00 ? 18  MET A HG2    1 
ATOM   51   H  HG3    . MET A 1 18  ? 315.056 216.300 95.150  1.00 48.33 ? 18  MET A HG3    1 
ATOM   52   H  HE1    . MET A 1 18  ? 316.010 213.746 93.868  1.00 40.91 ? 18  MET A HE1    1 
ATOM   53   H  HE2    . MET A 1 18  ? 317.538 213.680 94.286  1.00 43.18 ? 18  MET A HE2    1 
ATOM   54   H  HE3    . MET A 1 18  ? 316.891 215.062 93.849  1.00 42.55 ? 18  MET A HE3    1 
ATOM   55   N  N      . ARG A 1 19  ? 311.362 215.764 95.070  1.00 41.36 ? 19  ARG A N      1 
ATOM   56   C  CA     . ARG A 1 19  ? 310.218 214.965 94.663  1.00 38.37 ? 19  ARG A CA     1 
ATOM   57   C  C      . ARG A 1 19  ? 310.686 213.684 93.992  1.00 38.51 ? 19  ARG A C      1 
ATOM   58   O  O      . ARG A 1 19  ? 311.609 213.697 93.167  1.00 44.25 ? 19  ARG A O      1 
ATOM   59   C  CB     . ARG A 1 19  ? 309.295 215.735 93.730  1.00 39.46 ? 19  ARG A CB     1 
ATOM   60   C  CG     . ARG A 1 19  ? 308.126 214.905 93.293  1.00 43.01 ? 19  ARG A CG     1 
ATOM   61   C  CD     . ARG A 1 19  ? 307.026 215.719 92.671  1.00 46.03 ? 19  ARG A CD     1 
ATOM   62   N  NE     . ARG A 1 19  ? 306.146 214.880 91.867  1.00 47.14 ? 19  ARG A NE     1 
ATOM   63   C  CZ     . ARG A 1 19  ? 304.940 215.235 91.454  1.00 49.12 ? 19  ARG A CZ     1 
ATOM   64   N  NH1    . ARG A 1 19  ? 304.416 216.403 91.773  1.00 49.03 ? 19  ARG A NH1    1 
ATOM   65   N  NH2    . ARG A 1 19  ? 304.239 214.391 90.705  1.00 49.43 ? 19  ARG A NH2    1 
ATOM   66   H  H      . ARG A 1 19  ? 311.826 216.053 94.413  1.00 42.98 ? 19  ARG A H      1 
ATOM   67   H  HA     . ARG A 1 19  ? 309.707 214.720 95.442  1.00 41.38 ? 19  ARG A HA     1 
ATOM   68   H  HB2    . ARG A 1 19  ? 308.957 216.513 94.194  1.00 40.87 ? 19  ARG A HB2    1 
ATOM   69   H  HB3    . ARG A 1 19  ? 309.788 215.994 92.943  1.00 40.56 ? 19  ARG A HB3    1 
ATOM   70   H  HG2    . ARG A 1 19  ? 308.430 214.258 92.645  1.00 43.67 ? 19  ARG A HG2    1 
ATOM   71   H  HG3    . ARG A 1 19  ? 307.762 214.453 94.066  1.00 42.70 ? 19  ARG A HG3    1 
ATOM   72   H  HD2    . ARG A 1 19  ? 306.501 216.133 93.370  1.00 44.73 ? 19  ARG A HD2    1 
ATOM   73   H  HD3    . ARG A 1 19  ? 307.413 216.394 92.096  1.00 45.55 ? 19  ARG A HD3    1 
ATOM   74   H  HE     . ARG A 1 19  ? 306.432 214.105 91.634  1.00 46.77 ? 19  ARG A HE     1 
ATOM   75   H  HH11   . ARG A 1 19  ? 304.864 216.952 92.257  1.00 47.72 ? 19  ARG A HH11   1 
ATOM   76   H  HH12   . ARG A 1 19  ? 303.631 216.613 91.496  1.00 49.15 ? 19  ARG A HH12   1 
ATOM   77   H  HH21   . ARG A 1 19  ? 304.576 213.628 90.495  1.00 48.60 ? 19  ARG A HH21   1 
ATOM   78   H  HH22   . ARG A 1 19  ? 303.455 214.608 90.431  1.00 49.69 ? 19  ARG A HH22   1 
ATOM   79   N  N      . ILE A 1 20  ? 310.032 212.588 94.346  1.00 35.86 ? 20  ILE A N      1 
ATOM   80   C  CA     . ILE A 1 20  ? 310.446 211.254 93.959  1.00 34.25 ? 20  ILE A CA     1 
ATOM   81   C  C      . ILE A 1 20  ? 309.229 210.517 93.433  1.00 34.83 ? 20  ILE A C      1 
ATOM   82   O  O      . ILE A 1 20  ? 308.095 210.782 93.840  1.00 34.40 ? 20  ILE A O      1 
ATOM   83   C  CB     . ILE A 1 20  ? 311.068 210.493 95.145  1.00 32.19 ? 20  ILE A CB     1 
ATOM   84   C  CG1    . ILE A 1 20  ? 312.187 211.305 95.778  1.00 33.53 ? 20  ILE A CG1    1 
ATOM   85   C  CG2    . ILE A 1 20  ? 311.584 209.162 94.712  1.00 31.76 ? 20  ILE A CG2    1 
ATOM   86   C  CD1    . ILE A 1 20  ? 313.345 211.526 94.902  1.00 33.44 ? 20  ILE A CD1    1 
ATOM   87   H  H      . ILE A 1 20  ? 309.321 212.593 94.822  1.00 36.89 ? 20  ILE A H      1 
ATOM   88   H  HA     . ILE A 1 20  ? 311.102 211.311 93.255  1.00 35.33 ? 20  ILE A HA     1 
ATOM   89   H  HB     . ILE A 1 20  ? 310.380 210.356 95.807  1.00 33.21 ? 20  ILE A HB     1 
ATOM   90   H  HG12   . ILE A 1 20  ? 311.841 212.171 96.016  1.00 36.16 ? 20  ILE A HG12   1 
ATOM   91   H  HG13   . ILE A 1 20  ? 312.501 210.845 96.566  1.00 33.92 ? 20  ILE A HG13   1 
ATOM   92   H  HG21   . ILE A 1 20  ? 310.827 208.604 94.491  1.00 32.47 ? 20  ILE A HG21   1 
ATOM   93   H  HG22   . ILE A 1 20  ? 312.088 208.771 95.439  1.00 33.07 ? 20  ILE A HG22   1 
ATOM   94   H  HG23   . ILE A 1 20  ? 312.151 209.279 93.939  1.00 33.14 ? 20  ILE A HG23   1 
ATOM   95   H  HD11   . ILE A 1 20  ? 313.735 210.674 94.671  1.00 34.37 ? 20  ILE A HD11   1 
ATOM   96   H  HD12   . ILE A 1 20  ? 313.987 212.073 95.377  1.00 35.58 ? 20  ILE A HD12   1 
ATOM   97   H  HD13   . ILE A 1 20  ? 313.046 211.982 94.106  1.00 36.46 ? 20  ILE A HD13   1 
ATOM   98   N  N      . LEU A 1 21  ? 309.474 209.586 92.522  1.00 33.38 ? 21  LEU A N      1 
ATOM   99   C  CA     . LEU A 1 21  ? 308.428 208.731 91.979  1.00 30.18 ? 21  LEU A CA     1 
ATOM   100  C  C      . LEU A 1 21  ? 308.913 207.293 92.057  1.00 31.54 ? 21  LEU A C      1 
ATOM   101  O  O      . LEU A 1 21  ? 309.872 206.921 91.377  1.00 35.11 ? 21  LEU A O      1 
ATOM   102  C  CB     . LEU A 1 21  ? 308.088 209.128 90.548  1.00 30.84 ? 21  LEU A CB     1 
ATOM   103  C  CG     . LEU A 1 21  ? 306.982 208.361 89.838  1.00 31.91 ? 21  LEU A CG     1 
ATOM   104  C  CD1    . LEU A 1 21  ? 305.643 208.698 90.414  1.00 33.55 ? 21  LEU A CD1    1 
ATOM   105  C  CD2    . LEU A 1 21  ? 307.005 208.662 88.374  1.00 32.53 ? 21  LEU A CD2    1 
ATOM   106  H  H      . LEU A 1 21  ? 310.249 209.421 92.198  1.00 33.81 ? 21  LEU A H      1 
ATOM   107  H  HA     . LEU A 1 21  ? 307.634 208.811 92.516  1.00 31.55 ? 21  LEU A HA     1 
ATOM   108  H  HB2    . LEU A 1 21  ? 307.813 210.054 90.563  1.00 31.64 ? 21  LEU A HB2    1 
ATOM   109  H  HB3    . LEU A 1 21  ? 308.888 209.039 90.017  1.00 31.11 ? 21  LEU A HB3    1 
ATOM   110  H  HG     . LEU A 1 21  ? 307.129 207.419 89.952  1.00 31.96 ? 21  LEU A HG     1 
ATOM   111  H  HD11   . LEU A 1 21  ? 305.533 209.656 90.379  1.00 34.23 ? 21  LEU A HD11   1 
ATOM   112  H  HD12   . LEU A 1 21  ? 305.604 208.391 91.329  1.00 33.19 ? 21  LEU A HD12   1 
ATOM   113  H  HD13   . LEU A 1 21  ? 304.959 208.267 89.887  1.00 31.62 ? 21  LEU A HD13   1 
ATOM   114  H  HD21   . LEU A 1 21  ? 306.463 208.007 87.913  1.00 31.07 ? 21  LEU A HD21   1 
ATOM   115  H  HD22   . LEU A 1 21  ? 307.919 208.623 88.065  1.00 32.41 ? 21  LEU A HD22   1 
ATOM   116  H  HD23   . LEU A 1 21  ? 306.648 209.548 88.237  1.00 31.39 ? 21  LEU A HD23   1 
ATOM   117  N  N      . MET A 1 22  ? 308.275 206.497 92.906  1.00 29.34 ? 22  MET A N      1 
ATOM   118  C  CA     . MET A 1 22  ? 308.591 205.085 93.035  1.00 29.59 ? 22  MET A CA     1 
ATOM   119  C  C      . MET A 1 22  ? 307.683 204.302 92.108  1.00 27.33 ? 22  MET A C      1 
ATOM   120  O  O      . MET A 1 22  ? 306.460 204.444 92.166  1.00 29.94 ? 22  MET A O      1 
ATOM   121  C  CB     . MET A 1 22  ? 308.423 204.597 94.467  1.00 30.61 ? 22  MET A CB     1 
ATOM   122  C  CG     . MET A 1 22  ? 309.304 203.423 94.780  1.00 32.95 ? 22  MET A CG     1 
ATOM   123  S  SD     . MET A 1 22  ? 309.012 202.656 96.367  1.00 43.40 ? 22  MET A SD     1 
ATOM   124  C  CE     . MET A 1 22  ? 308.957 204.103 97.374  1.00 29.44 ? 22  MET A CE     1 
ATOM   125  H  H      . MET A 1 22  ? 307.644 206.754 93.422  1.00 30.31 ? 22  MET A H      1 
ATOM   126  H  HA     . MET A 1 22  ? 309.507 204.937 92.776  1.00 31.17 ? 22  MET A HA     1 
ATOM   127  H  HB2    . MET A 1 22  ? 308.656 205.318 95.067  1.00 30.61 ? 22  MET A HB2    1 
ATOM   128  H  HB3    . MET A 1 22  ? 307.507 204.325 94.599  1.00 29.97 ? 22  MET A HB3    1 
ATOM   129  H  HG2    . MET A 1 22  ? 309.176 202.756 94.096  1.00 32.66 ? 22  MET A HG2    1 
ATOM   130  H  HG3    . MET A 1 22  ? 310.220 203.737 94.785  1.00 33.37 ? 22  MET A HG3    1 
ATOM   131  H  HE1    . MET A 1 22  ? 309.782 204.581 97.233  1.00 29.73 ? 22  MET A HE1    1 
ATOM   132  H  HE2    . MET A 1 22  ? 308.870 203.842 98.299  1.00 31.30 ? 22  MET A HE2    1 
ATOM   133  H  HE3    . MET A 1 22  ? 308.204 204.645 97.103  1.00 30.65 ? 22  MET A HE3    1 
ATOM   134  N  N      . VAL A 1 23  ? 308.284 203.476 91.258  1.00 26.99 ? 23  VAL A N      1 
ATOM   135  C  CA     . VAL A 1 23  ? 307.555 202.741 90.242  1.00 26.92 ? 23  VAL A CA     1 
ATOM   136  C  C      . VAL A 1 23  ? 308.209 201.381 90.071  1.00 28.77 ? 23  VAL A C      1 
ATOM   137  O  O      . VAL A 1 23  ? 309.252 201.085 90.654  1.00 32.54 ? 23  VAL A O      1 
ATOM   138  C  CB     . VAL A 1 23  ? 307.502 203.480 88.895  1.00 28.25 ? 23  VAL A CB     1 
ATOM   139  C  CG1    . VAL A 1 23  ? 306.798 204.775 89.043  1.00 31.06 ? 23  VAL A CG1    1 
ATOM   140  C  CG2    . VAL A 1 23  ? 308.875 203.714 88.369  1.00 29.61 ? 23  VAL A CG2    1 
ATOM   141  H  H      . VAL A 1 23  ? 309.127 203.319 91.252  1.00 28.79 ? 23  VAL A H      1 
ATOM   142  H  HA     . VAL A 1 23  ? 306.649 202.608 90.542  1.00 27.93 ? 23  VAL A HA     1 
ATOM   143  H  HB     . VAL A 1 23  ? 307.022 202.941 88.258  1.00 28.59 ? 23  VAL A HB     1 
ATOM   144  H  HG11   . VAL A 1 23  ? 305.876 204.605 89.277  1.00 30.13 ? 23  VAL A HG11   1 
ATOM   145  H  HG12   . VAL A 1 23  ? 306.851 205.257 88.206  1.00 30.73 ? 23  VAL A HG12   1 
ATOM   146  H  HG13   . VAL A 1 23  ? 307.235 205.268 89.744  1.00 30.62 ? 23  VAL A HG13   1 
ATOM   147  H  HG21   . VAL A 1 23  ? 309.486 203.833 89.108  1.00 29.33 ? 23  VAL A HG21   1 
ATOM   148  H  HG22   . VAL A 1 23  ? 308.853 204.509 87.821  1.00 29.04 ? 23  VAL A HG22   1 
ATOM   149  H  HG23   . VAL A 1 23  ? 309.139 202.947 87.845  1.00 28.58 ? 23  VAL A HG23   1 
ATOM   150  N  N      . GLY A 1 24  ? 307.569 200.556 89.268  1.00 27.95 ? 24  GLY A N      1 
ATOM   151  C  CA     . GLY A 1 24  ? 308.003 199.192 89.082  1.00 29.66 ? 24  GLY A CA     1 
ATOM   152  C  C      . GLY A 1 24  ? 306.825 198.328 88.703  1.00 32.31 ? 24  GLY A C      1 
ATOM   153  O  O      . GLY A 1 24  ? 305.709 198.805 88.507  1.00 33.12 ? 24  GLY A O      1 
ATOM   154  H  H      . GLY A 1 24  ? 306.875 200.764 88.816  1.00 29.00 ? 24  GLY A H      1 
ATOM   155  H  HA2    . GLY A 1 24  ? 308.653 199.152 88.372  1.00 30.11 ? 24  GLY A HA2    1 
ATOM   156  H  HA3    . GLY A 1 24  ? 308.402 198.856 89.893  1.00 28.75 ? 24  GLY A HA3    1 
ATOM   157  N  N      . LEU A 1 25  ? 307.103 197.040 88.596  1.00 34.26 ? 25  LEU A N      1 
ATOM   158  C  CA     . LEU A 1 25  ? 306.066 196.071 88.286  1.00 33.20 ? 25  LEU A CA     1 
ATOM   159  C  C      . LEU A 1 25  ? 305.303 195.720 89.558  1.00 34.24 ? 25  LEU A C      1 
ATOM   160  O  O      . LEU A 1 25  ? 305.618 196.183 90.655  1.00 36.89 ? 25  LEU A O      1 
ATOM   161  C  CB     . LEU A 1 25  ? 306.672 194.843 87.626  1.00 35.25 ? 25  LEU A CB     1 
ATOM   162  C  CG     . LEU A 1 25  ? 307.467 195.098 86.355  1.00 37.35 ? 25  LEU A CG     1 
ATOM   163  C  CD1    . LEU A 1 25  ? 307.820 193.792 85.728  1.00 39.80 ? 25  LEU A CD1    1 
ATOM   164  C  CD2    . LEU A 1 25  ? 306.684 195.934 85.395  1.00 37.33 ? 25  LEU A CD2    1 
ATOM   165  H  H      . LEU A 1 25  ? 307.883 196.702 88.688  1.00 34.26 ? 25  LEU A H      1 
ATOM   166  H  HA     . LEU A 1 25  ? 305.445 196.472 87.670  1.00 33.58 ? 25  LEU A HA     1 
ATOM   167  H  HB2    . LEU A 1 25  ? 307.263 194.408 88.258  1.00 35.16 ? 25  LEU A HB2    1 
ATOM   168  H  HB3    . LEU A 1 25  ? 305.952 194.246 87.389  1.00 34.90 ? 25  LEU A HB3    1 
ATOM   169  H  HG     . LEU A 1 25  ? 308.282 195.563 86.579  1.00 36.73 ? 25  LEU A HG     1 
ATOM   170  H  HD11   . LEU A 1 25  ? 308.418 193.312 86.318  1.00 38.37 ? 25  LEU A HD11   1 
ATOM   171  H  HD12   . LEU A 1 25  ? 308.249 193.960 84.880  1.00 38.07 ? 25  LEU A HD12   1 
ATOM   172  H  HD13   . LEU A 1 25  ? 307.004 193.290 85.593  1.00 37.55 ? 25  LEU A HD13   1 
ATOM   173  H  HD21   . LEU A 1 25  ? 306.672 196.848 85.705  1.00 35.86 ? 25  LEU A HD21   1 
ATOM   174  H  HD22   . LEU A 1 25  ? 305.785 195.586 85.352  1.00 36.43 ? 25  LEU A HD22   1 
ATOM   175  H  HD23   . LEU A 1 25  ? 307.105 195.889 84.525  1.00 36.42 ? 25  LEU A HD23   1 
ATOM   176  N  N      . ASP A 1 26  ? 304.272 194.897 89.414  1.00 34.37 ? 26  ASP A N      1 
ATOM   177  C  CA     . ASP A 1 26  ? 303.501 194.439 90.556  1.00 32.35 ? 26  ASP A CA     1 
ATOM   178  C  C      . ASP A 1 26  ? 304.282 193.398 91.347  1.00 34.87 ? 26  ASP A C      1 
ATOM   179  O  O      . ASP A 1 26  ? 304.946 192.530 90.778  1.00 40.79 ? 26  ASP A O      1 
ATOM   180  C  CB     . ASP A 1 26  ? 302.158 193.862 90.112  1.00 35.39 ? 26  ASP A CB     1 
ATOM   181  C  CG     . ASP A 1 26  ? 302.244 193.090 88.823  1.00 45.37 ? 26  ASP A CG     1 
ATOM   182  O  OD1    . ASP A 1 26  ? 302.768 193.641 87.833  1.00 47.00 ? 26  ASP A OD1    1 
ATOM   183  O  OD2    . ASP A 1 26  ? 301.777 191.934 88.793  1.00 49.01 ? 26  ASP A OD2    1 
ATOM   184  H  H      . ASP A 1 26  ? 304.006 194.604 88.658  1.00 37.20 ? 26  ASP A H      1 
ATOM   185  H  HA     . ASP A 1 26  ? 303.327 195.191 91.134  1.00 34.84 ? 26  ASP A HA     1 
ATOM   186  H  HB2    . ASP A 1 26  ? 301.837 193.258 90.795  1.00 37.34 ? 26  ASP A HB2    1 
ATOM   187  H  HB3    . ASP A 1 26  ? 301.531 194.584 89.985  1.00 37.24 ? 26  ASP A HB3    1 
ATOM   188  N  N      . GLY A 1 27  ? 304.192 193.493 92.669  1.00 30.47 ? 27  GLY A N      1 
ATOM   189  C  CA     . GLY A 1 27  ? 304.874 192.560 93.538  1.00 29.48 ? 27  GLY A CA     1 
ATOM   190  C  C      . GLY A 1 27  ? 306.280 192.950 93.912  1.00 32.26 ? 27  GLY A C      1 
ATOM   191  O  O      . GLY A 1 27  ? 306.936 192.226 94.663  1.00 36.03 ? 27  GLY A O      1 
ATOM   192  H  H      . GLY A 1 27  ? 303.747 194.093 93.084  1.00 32.19 ? 27  GLY A H      1 
ATOM   193  H  HA2    . GLY A 1 27  ? 304.362 192.462 94.350  1.00 29.99 ? 27  GLY A HA2    1 
ATOM   194  H  HA3    . GLY A 1 27  ? 304.907 191.701 93.100  1.00 31.91 ? 27  GLY A HA3    1 
ATOM   195  N  N      . ALA A 1 28  ? 306.760 194.087 93.418  1.00 29.76 ? 28  ALA A N      1 
ATOM   196  C  CA     . ALA A 1 28  ? 308.143 194.496 93.598  1.00 31.07 ? 28  ALA A CA     1 
ATOM   197  C  C      . ALA A 1 28  ? 308.497 194.834 95.037  1.00 31.73 ? 28  ALA A C      1 
ATOM   198  O  O      . ALA A 1 28  ? 309.492 194.309 95.544  1.00 32.64 ? 28  ALA A O      1 
ATOM   199  C  CB     . ALA A 1 28  ? 308.423 195.698 92.710  1.00 30.38 ? 28  ALA A CB     1 
ATOM   200  H  H      . ALA A 1 28  ? 306.297 194.637 92.959  1.00 30.99 ? 28  ALA A H      1 
ATOM   201  H  HA     . ALA A 1 28  ? 308.724 193.779 93.320  1.00 32.15 ? 28  ALA A HA     1 
ATOM   202  H  HB1    . ALA A 1 28  ? 307.978 196.468 93.082  1.00 31.03 ? 28  ALA A HB1    1 
ATOM   203  H  HB2    . ALA A 1 28  ? 308.073 195.513 91.828  1.00 31.36 ? 28  ALA A HB2    1 
ATOM   204  H  HB3    . ALA A 1 28  ? 309.375 195.852 92.681  1.00 31.88 ? 28  ALA A HB3    1 
ATOM   205  N  N      . GLY A 1 29  ? 307.724 195.687 95.702  1.00 32.46 ? 29  GLY A N      1 
ATOM   206  C  CA     . GLY A 1 29  ? 308.078 196.140 97.028  1.00 30.23 ? 29  GLY A CA     1 
ATOM   207  C  C      . GLY A 1 29  ? 308.006 197.631 97.225  1.00 31.08 ? 29  GLY A C      1 
ATOM   208  O  O      . GLY A 1 29  ? 308.606 198.148 98.168  1.00 31.23 ? 29  GLY A O      1 
ATOM   209  H  H      . GLY A 1 29  ? 306.978 196.001 95.418  1.00 32.38 ? 29  GLY A H      1 
ATOM   210  H  HA2    . GLY A 1 29  ? 307.485 195.728 97.668  1.00 29.04 ? 29  GLY A HA2    1 
ATOM   211  H  HA3    . GLY A 1 29  ? 308.979 195.859 97.228  1.00 31.38 ? 29  GLY A HA3    1 
ATOM   212  N  N      . LYS A 1 30  ? 307.257 198.338 96.385  1.00 30.39 ? 30  LYS A N      1 
ATOM   213  C  CA     . LYS A 1 30  ? 307.243 199.791 96.452  1.00 27.78 ? 30  LYS A CA     1 
ATOM   214  C  C      . LYS A 1 30  ? 306.589 200.296 97.728  1.00 28.52 ? 30  LYS A C      1 
ATOM   215  O  O      . LYS A 1 30  ? 307.182 201.100 98.457  1.00 33.03 ? 30  LYS A O      1 
ATOM   216  C  CB     . LYS A 1 30  ? 306.521 200.355 95.240  1.00 29.89 ? 30  LYS A CB     1 
ATOM   217  C  CG     . LYS A 1 30  ? 306.907 199.717 93.944  1.00 29.60 ? 30  LYS A CG     1 
ATOM   218  C  CD     . LYS A 1 30  ? 306.405 200.501 92.772  1.00 31.63 ? 30  LYS A CD     1 
ATOM   219  C  CE     . LYS A 1 30  ? 304.977 200.195 92.476  1.00 31.66 ? 30  LYS A CE     1 
ATOM   220  N  NZ     . LYS A 1 30  ? 304.841 198.833 91.951  1.00 31.22 ? 30  LYS A NZ     1 
ATOM   221  H  H      . LYS A 1 30  ? 306.746 198.002 95.787  1.00 30.76 ? 30  LYS A H      1 
ATOM   222  H  HA     . LYS A 1 30  ? 308.149 200.111 96.438  1.00 30.04 ? 30  LYS A HA     1 
ATOM   223  H  HB2    . LYS A 1 30  ? 305.574 200.229 95.357  1.00 30.69 ? 30  LYS A HB2    1 
ATOM   224  H  HB3    . LYS A 1 30  ? 306.728 201.295 95.175  1.00 30.26 ? 30  LYS A HB3    1 
ATOM   225  H  HG2    . LYS A 1 30  ? 307.869 199.665 93.892  1.00 29.97 ? 30  LYS A HG2    1 
ATOM   226  H  HG3    . LYS A 1 30  ? 306.516 198.837 93.894  1.00 30.07 ? 30  LYS A HG3    1 
ATOM   227  H  HD2    . LYS A 1 30  ? 306.484 201.445 92.958  1.00 31.30 ? 30  LYS A HD2    1 
ATOM   228  H  HD3    . LYS A 1 30  ? 306.914 200.256 91.992  1.00 30.90 ? 30  LYS A HD3    1 
ATOM   229  H  HE2    . LYS A 1 30  ? 304.467 200.265 93.292  1.00 31.44 ? 30  LYS A HE2    1 
ATOM   230  H  HE3    . LYS A 1 30  ? 304.645 200.809 91.810  1.00 30.52 ? 30  LYS A HE3    1 
ATOM   231  H  HZ1    . LYS A 1 30  ? 304.003 198.689 91.701  1.00 32.04 ? 30  LYS A HZ1    1 
ATOM   232  H  HZ2    . LYS A 1 30  ? 305.065 198.254 92.582  1.00 30.59 ? 30  LYS A HZ2    1 
ATOM   233  H  HZ3    . LYS A 1 30  ? 305.376 198.722 91.253  1.00 31.92 ? 30  LYS A HZ3    1 
ATOM   234  N  N      . THR A 1 31  ? 305.366 199.857 98.003  1.00 30.25 ? 31  THR A N      1 
ATOM   235  C  CA     . THR A 1 31  ? 304.640 200.266 99.192  1.00 31.86 ? 31  THR A CA     1 
ATOM   236  C  C      . THR A 1 31  ? 305.383 199.883 100.459 1.00 30.41 ? 31  THR A C      1 
ATOM   237  O  O      . THR A 1 31  ? 305.454 200.672 101.410 1.00 33.64 ? 31  THR A O      1 
ATOM   238  C  CB     . THR A 1 31  ? 303.260 199.617 99.196  1.00 34.99 ? 31  THR A CB     1 
ATOM   239  O  OG1    . THR A 1 31  ? 302.736 199.587 97.863  1.00 39.14 ? 31  THR A OG1    1 
ATOM   240  C  CG2    . THR A 1 31  ? 302.319 200.383 100.072 1.00 33.94 ? 31  THR A CG2    1 
ATOM   241  H  H      . THR A 1 31  ? 304.930 199.314 97.510  1.00 31.44 ? 31  THR A H      1 
ATOM   242  H  HA     . THR A 1 31  ? 304.522 201.222 99.183  1.00 32.47 ? 31  THR A HA     1 
ATOM   243  H  HB     . THR A 1 31  ? 303.340 198.720 99.538  1.00 33.91 ? 31  THR A HB     1 
ATOM   244  H  HG1    . THR A 1 31  ? 302.616 200.368 97.585  1.00 35.53 ? 31  THR A HG1    1 
ATOM   245  H  HG21   . THR A 1 31  ? 302.687 200.450 100.964 1.00 33.02 ? 31  THR A HG21   1 
ATOM   246  H  HG22   . THR A 1 31  ? 301.464 199.931 100.112 1.00 35.90 ? 31  THR A HG22   1 
ATOM   247  H  HG23   . THR A 1 31  ? 302.195 201.272 99.710  1.00 31.86 ? 31  THR A HG23   1 
ATOM   248  N  N      . THR A 1 32  ? 305.929 198.670 100.481 1.00 30.60 ? 32  THR A N      1 
ATOM   249  C  CA     . THR A 1 32  ? 306.698 198.210 101.625 1.00 27.25 ? 32  THR A CA     1 
ATOM   250  C  C      . THR A 1 32  ? 307.920 199.081 101.864 1.00 29.10 ? 32  THR A C      1 
ATOM   251  O  O      . THR A 1 32  ? 308.203 199.450 103.005 1.00 34.60 ? 32  THR A O      1 
ATOM   252  C  CB     . THR A 1 32  ? 307.106 196.760 101.405 1.00 29.03 ? 32  THR A CB     1 
ATOM   253  O  OG1    . THR A 1 32  ? 305.968 196.004 100.983 1.00 33.88 ? 32  THR A OG1    1 
ATOM   254  C  CG2    . THR A 1 32  ? 307.634 196.169 102.659 1.00 31.45 ? 32  THR A CG2    1 
ATOM   255  H  H      . THR A 1 32  ? 305.866 198.098 99.850  1.00 31.44 ? 32  THR A H      1 
ATOM   256  H  HA     . THR A 1 32  ? 306.146 198.252 102.415 1.00 29.10 ? 32  THR A HA     1 
ATOM   257  H  HB     . THR A 1 32  ? 307.791 196.721 100.728 1.00 30.40 ? 32  THR A HB     1 
ATOM   258  H  HG1    . THR A 1 32  ? 305.684 196.309 100.257 1.00 32.93 ? 32  THR A HG1    1 
ATOM   259  H  HG21   . THR A 1 32  ? 307.027 196.365 103.385 1.00 31.66 ? 32  THR A HG21   1 
ATOM   260  H  HG22   . THR A 1 32  ? 308.504 196.544 102.854 1.00 31.36 ? 32  THR A HG22   1 
ATOM   261  H  HG23   . THR A 1 32  ? 307.714 195.210 102.557 1.00 30.58 ? 32  THR A HG23   1 
ATOM   262  N  N      . VAL A 1 33  ? 308.651 199.421 100.807 1.00 30.32 ? 33  VAL A N      1 
ATOM   263  C  CA     . VAL A 1 33  ? 309.786 200.325 100.935 1.00 29.29 ? 33  VAL A CA     1 
ATOM   264  C  C      . VAL A 1 33  ? 309.345 201.667 101.495 1.00 29.86 ? 33  VAL A C      1 
ATOM   265  O  O      . VAL A 1 33  ? 309.981 202.222 102.401 1.00 33.38 ? 33  VAL A O      1 
ATOM   266  C  CB     . VAL A 1 33  ? 310.471 200.488 99.570  1.00 29.87 ? 33  VAL A CB     1 
ATOM   267  C  CG1    . VAL A 1 33  ? 311.491 201.573 99.620  1.00 29.12 ? 33  VAL A CG1    1 
ATOM   268  C  CG2    . VAL A 1 33  ? 311.099 199.205 99.132  1.00 30.70 ? 33  VAL A CG2    1 
ATOM   269  H  H      . VAL A 1 33  ? 308.518 199.141 100.012 1.00 30.93 ? 33  VAL A H      1 
ATOM   270  H  HA     . VAL A 1 33  ? 310.425 199.944 101.545 1.00 29.76 ? 33  VAL A HA     1 
ATOM   271  H  HB     . VAL A 1 33  ? 309.809 200.732 98.914  1.00 30.50 ? 33  VAL A HB     1 
ATOM   272  H  HG11   . VAL A 1 33  ? 311.036 202.426 99.643  1.00 29.76 ? 33  VAL A HG11   1 
ATOM   273  H  HG12   . VAL A 1 33  ? 312.045 201.509 98.828  1.00 29.61 ? 33  VAL A HG12   1 
ATOM   274  H  HG13   . VAL A 1 33  ? 312.027 201.455 100.415 1.00 29.48 ? 33  VAL A HG13   1 
ATOM   275  H  HG21   . VAL A 1 33  ? 310.851 199.042 98.213  1.00 29.98 ? 33  VAL A HG21   1 
ATOM   276  H  HG22   . VAL A 1 33  ? 310.776 198.491 99.696  1.00 30.41 ? 33  VAL A HG22   1 
ATOM   277  H  HG23   . VAL A 1 33  ? 312.060 199.286 99.202  1.00 30.87 ? 33  VAL A HG23   1 
ATOM   278  N  N      . LEU A 1 34  ? 308.255 202.209 100.965 1.00 28.76 ? 34  LEU A N      1 
ATOM   279  C  CA     . LEU A 1 34  ? 307.820 203.537 101.370 1.00 29.95 ? 34  LEU A CA     1 
ATOM   280  C  C      . LEU A 1 34  ? 307.459 203.567 102.846 1.00 32.03 ? 34  LEU A C      1 
ATOM   281  O  O      . LEU A 1 34  ? 307.885 204.463 103.584 1.00 33.67 ? 34  LEU A O      1 
ATOM   282  C  CB     . LEU A 1 34  ? 306.635 203.975 100.519 1.00 29.82 ? 34  LEU A CB     1 
ATOM   283  C  CG     . LEU A 1 34  ? 306.024 205.319 100.874 1.00 33.11 ? 34  LEU A CG     1 
ATOM   284  C  CD1    . LEU A 1 34  ? 307.051 206.394 100.771 1.00 34.40 ? 34  LEU A CD1    1 
ATOM   285  C  CD2    . LEU A 1 34  ? 304.889 205.614 99.962  1.00 34.09 ? 34  LEU A CD2    1 
ATOM   286  H  H      . LEU A 1 34  ? 307.756 201.834 100.380 1.00 30.25 ? 34  LEU A H      1 
ATOM   287  H  HA     . LEU A 1 34  ? 308.541 204.159 101.226 1.00 30.42 ? 34  LEU A HA     1 
ATOM   288  H  HB2    . LEU A 1 34  ? 306.927 204.032 99.601  1.00 30.40 ? 34  LEU A HB2    1 
ATOM   289  H  HB3    . LEU A 1 34  ? 305.937 203.311 100.601 1.00 30.98 ? 34  LEU A HB3    1 
ATOM   290  H  HG     . LEU A 1 34  ? 305.691 205.296 101.779 1.00 33.56 ? 34  LEU A HG     1 
ATOM   291  H  HD11   . LEU A 1 34  ? 307.717 206.259 101.460 1.00 33.79 ? 34  LEU A HD11   1 
ATOM   292  H  HD12   . LEU A 1 34  ? 307.459 206.343 99.896  1.00 32.71 ? 34  LEU A HD12   1 
ATOM   293  H  HD13   . LEU A 1 34  ? 306.615 207.249 100.889 1.00 33.92 ? 34  LEU A HD13   1 
ATOM   294  H  HD21   . LEU A 1 34  ? 305.213 205.589 99.053  1.00 33.05 ? 34  LEU A HD21   1 
ATOM   295  H  HD22   . LEU A 1 34  ? 304.552 206.494 100.175 1.00 32.84 ? 34  LEU A HD22   1 
ATOM   296  H  HD23   . LEU A 1 34  ? 304.202 204.948 100.093 1.00 33.16 ? 34  LEU A HD23   1 
ATOM   297  N  N      . TYR A 1 35  ? 306.680 202.592 103.299 1.00 31.74 ? 35  TYR A N      1 
ATOM   298  C  CA     . TYR A 1 35  ? 306.250 202.569 104.688 1.00 31.42 ? 35  TYR A CA     1 
ATOM   299  C  C      . TYR A 1 35  ? 307.243 201.875 105.608 1.00 31.97 ? 35  TYR A C      1 
ATOM   300  O  O      . TYR A 1 35  ? 306.957 201.726 106.798 1.00 38.38 ? 35  TYR A O      1 
ATOM   301  C  CB     . TYR A 1 35  ? 304.878 201.915 104.786 1.00 32.28 ? 35  TYR A CB     1 
ATOM   302  C  CG     . TYR A 1 35  ? 303.799 202.774 104.190 1.00 32.82 ? 35  TYR A CG     1 
ATOM   303  C  CD1    . TYR A 1 35  ? 303.450 203.975 104.772 1.00 34.84 ? 35  TYR A CD1    1 
ATOM   304  C  CD2    . TYR A 1 35  ? 303.144 202.397 103.037 1.00 33.09 ? 35  TYR A CD2    1 
ATOM   305  C  CE1    . TYR A 1 35  ? 302.480 204.769 104.231 1.00 36.91 ? 35  TYR A CE1    1 
ATOM   306  C  CE2    . TYR A 1 35  ? 302.169 203.186 102.487 1.00 39.49 ? 35  TYR A CE2    1 
ATOM   307  C  CZ     . TYR A 1 35  ? 301.840 204.375 103.089 1.00 41.59 ? 35  TYR A CZ     1 
ATOM   308  O  OH     . TYR A 1 35  ? 300.866 205.182 102.556 1.00 47.76 ? 35  TYR A OH     1 
ATOM   309  H  H      . TYR A 1 35  ? 306.384 201.945 102.826 1.00 32.12 ? 35  TYR A H      1 
ATOM   310  H  HA     . TYR A 1 35  ? 306.160 203.478 104.992 1.00 32.53 ? 35  TYR A HA     1 
ATOM   311  H  HB2    . TYR A 1 35  ? 304.895 201.082 104.300 1.00 32.49 ? 35  TYR A HB2    1 
ATOM   312  H  HB3    . TYR A 1 35  ? 304.666 201.760 105.714 1.00 33.14 ? 35  TYR A HB3    1 
ATOM   313  H  HD1    . TYR A 1 35  ? 303.882 204.246 105.544 1.00 34.64 ? 35  TYR A HD1    1 
ATOM   314  H  HD2    . TYR A 1 35  ? 303.365 201.595 102.630 1.00 33.80 ? 35  TYR A HD2    1 
ATOM   315  H  HE1    . TYR A 1 35  ? 302.256 205.573 104.634 1.00 37.26 ? 35  TYR A HE1    1 
ATOM   316  H  HE2    . TYR A 1 35  ? 301.738 202.917 101.713 1.00 39.08 ? 35  TYR A HE2    1 
ATOM   317  H  HH     . TYR A 1 35  ? 300.604 204.870 101.824 1.00 44.54 ? 35  TYR A HH     1 
ATOM   318  N  N      . LYS A 1 36  ? 308.380 201.434 105.084 1.00 32.46 ? 36  LYS A N      1 
ATOM   319  C  CA     . LYS A 1 36  ? 309.538 201.128 105.908 1.00 32.39 ? 36  LYS A CA     1 
ATOM   320  C  C      . LYS A 1 36  ? 310.402 202.351 106.136 1.00 33.52 ? 36  LYS A C      1 
ATOM   321  O  O      . LYS A 1 36  ? 311.027 202.479 107.194 1.00 36.89 ? 36  LYS A O      1 
ATOM   322  C  CB     . LYS A 1 36  ? 310.379 200.044 105.244 1.00 31.20 ? 36  LYS A CB     1 
ATOM   323  C  CG     . LYS A 1 36  ? 311.368 199.376 106.148 1.00 33.65 ? 36  LYS A CG     1 
ATOM   324  C  CD     . LYS A 1 36  ? 310.698 198.322 106.979 1.00 38.39 ? 36  LYS A CD     1 
ATOM   325  C  CE     . LYS A 1 36  ? 311.682 197.588 107.849 1.00 36.61 ? 36  LYS A CE     1 
ATOM   326  N  NZ     . LYS A 1 36  ? 312.300 198.488 108.821 1.00 37.84 ? 36  LYS A NZ     1 
ATOM   327  H  H      . LYS A 1 36  ? 308.511 201.309 104.249 1.00 32.82 ? 36  LYS A H      1 
ATOM   328  H  HA     . LYS A 1 36  ? 309.242 200.798 106.762 1.00 33.09 ? 36  LYS A HA     1 
ATOM   329  H  HB2    . LYS A 1 36  ? 309.792 199.363 104.893 1.00 32.47 ? 36  LYS A HB2    1 
ATOM   330  H  HB3    . LYS A 1 36  ? 310.884 200.457 104.533 1.00 31.31 ? 36  LYS A HB3    1 
ATOM   331  H  HG2    . LYS A 1 36  ? 312.044 198.945 105.609 1.00 33.64 ? 36  LYS A HG2    1 
ATOM   332  H  HG3    . LYS A 1 36  ? 311.762 200.033 106.736 1.00 33.88 ? 36  LYS A HG3    1 
ATOM   333  H  HD2    . LYS A 1 36  ? 310.046 198.746 107.551 1.00 37.18 ? 36  LYS A HD2    1 
ATOM   334  H  HD3    . LYS A 1 36  ? 310.270 197.684 106.391 1.00 37.15 ? 36  LYS A HD3    1 
ATOM   335  H  HE2    . LYS A 1 36  ? 311.231 196.884 108.336 1.00 35.45 ? 36  LYS A HE2    1 
ATOM   336  H  HE3    . LYS A 1 36  ? 312.386 197.223 107.297 1.00 35.71 ? 36  LYS A HE3    1 
ATOM   337  H  HZ1    . LYS A 1 36  ? 312.814 198.023 109.376 1.00 38.62 ? 36  LYS A HZ1    1 
ATOM   338  H  HZ2    . LYS A 1 36  ? 311.670 198.907 109.285 1.00 37.51 ? 36  LYS A HZ2    1 
ATOM   339  H  HZ3    . LYS A 1 36  ? 312.793 199.085 108.390 1.00 36.46 ? 36  LYS A HZ3    1 
ATOM   340  N  N      . LEU A 1 37  ? 310.474 203.239 105.152 1.00 34.11 ? 37  LEU A N      1 
ATOM   341  C  CA     . LEU A 1 37  ? 311.137 204.520 105.326 1.00 34.42 ? 37  LEU A CA     1 
ATOM   342  C  C      . LEU A 1 37  ? 310.354 205.477 106.209 1.00 33.39 ? 37  LEU A C      1 
ATOM   343  O  O      . LEU A 1 37  ? 310.952 206.137 107.064 1.00 35.93 ? 37  LEU A O      1 
ATOM   344  C  CB     . LEU A 1 37  ? 311.374 205.185 103.971 1.00 33.12 ? 37  LEU A CB     1 
ATOM   345  C  CG     . LEU A 1 37  ? 312.327 204.509 103.002 1.00 32.79 ? 37  LEU A CG     1 
ATOM   346  C  CD1    . LEU A 1 37  ? 312.220 205.138 101.642 1.00 32.54 ? 37  LEU A CD1    1 
ATOM   347  C  CD2    . LEU A 1 37  ? 313.715 204.639 103.511 1.00 29.85 ? 37  LEU A CD2    1 
ATOM   348  H  H      . LEU A 1 37  ? 310.147 203.121 104.370 1.00 33.65 ? 37  LEU A H      1 
ATOM   349  H  HA     . LEU A 1 37  ? 311.996 204.372 105.738 1.00 33.75 ? 37  LEU A HA     1 
ATOM   350  H  HB2    . LEU A 1 37  ? 310.520 205.268 103.527 1.00 33.44 ? 37  LEU A HB2    1 
ATOM   351  H  HB3    . LEU A 1 37  ? 311.737 206.063 104.138 1.00 32.85 ? 37  LEU A HB3    1 
ATOM   352  H  HG     . LEU A 1 37  ? 312.113 203.571 102.933 1.00 33.23 ? 37  LEU A HG     1 
ATOM   353  H  HD11   . LEU A 1 37  ? 312.576 206.035 101.692 1.00 33.73 ? 37  LEU A HD11   1 
ATOM   354  H  HD12   . LEU A 1 37  ? 311.291 205.168 101.375 1.00 31.11 ? 37  LEU A HD12   1 
ATOM   355  H  HD13   . LEU A 1 37  ? 312.732 204.610 101.013 1.00 31.64 ? 37  LEU A HD13   1 
ATOM   356  H  HD21   . LEU A 1 37  ? 314.310 204.163 102.918 1.00 30.16 ? 37  LEU A HD21   1 
ATOM   357  H  HD22   . LEU A 1 37  ? 313.754 204.267 104.401 1.00 30.58 ? 37  LEU A HD22   1 
ATOM   358  H  HD23   . LEU A 1 37  ? 313.942 205.578 103.531 1.00 29.80 ? 37  LEU A HD23   1 
ATOM   359  N  N      . LYS A 1 38  ? 309.040 205.550 106.040 1.00 32.98 ? 38  LYS A N      1 
ATOM   360  C  CA     . LYS A 1 38  ? 308.192 206.497 106.746 1.00 34.56 ? 38  LYS A CA     1 
ATOM   361  C  C      . LYS A 1 38  ? 307.875 206.095 108.176 1.00 34.38 ? 38  LYS A C      1 
ATOM   362  O  O      . LYS A 1 38  ? 307.943 206.936 109.073 1.00 31.60 ? 38  LYS A O      1 
ATOM   363  C  CB     . LYS A 1 38  ? 306.889 206.674 105.964 1.00 36.69 ? 38  LYS A CB     1 
ATOM   364  C  CG     . LYS A 1 38  ? 305.841 207.544 106.601 1.00 37.26 ? 38  LYS A CG     1 
ATOM   365  C  CD     . LYS A 1 38  ? 306.229 208.993 106.560 1.00 39.69 ? 38  LYS A CD     1 
ATOM   366  C  CE     . LYS A 1 38  ? 305.307 209.821 107.412 1.00 41.40 ? 38  LYS A CE     1 
ATOM   367  N  NZ     . LYS A 1 38  ? 305.629 211.262 107.345 1.00 40.03 ? 38  LYS A NZ     1 
ATOM   368  H  H      . LYS A 1 38  ? 308.607 205.046 105.503 1.00 33.74 ? 38  LYS A H      1 
ATOM   369  H  HA     . LYS A 1 38  ? 308.639 207.352 106.778 1.00 34.84 ? 38  LYS A HA     1 
ATOM   370  H  HB2    . LYS A 1 38  ? 307.105 207.066 105.107 1.00 35.49 ? 38  LYS A HB2    1 
ATOM   371  H  HB3    . LYS A 1 38  ? 306.498 205.800 105.836 1.00 35.47 ? 38  LYS A HB3    1 
ATOM   372  H  HG2    . LYS A 1 38  ? 305.019 207.448 106.098 1.00 36.22 ? 38  LYS A HG2    1 
ATOM   373  H  HG3    . LYS A 1 38  ? 305.704 207.289 107.522 1.00 36.83 ? 38  LYS A HG3    1 
ATOM   374  H  HD2    . LYS A 1 38  ? 307.131 209.093 106.893 1.00 38.31 ? 38  LYS A HD2    1 
ATOM   375  H  HD3    . LYS A 1 38  ? 306.163 209.310 105.650 1.00 38.91 ? 38  LYS A HD3    1 
ATOM   376  H  HE2    . LYS A 1 38  ? 304.400 209.696 107.101 1.00 39.83 ? 38  LYS A HE2    1 
ATOM   377  H  HE3    . LYS A 1 38  ? 305.390 209.536 108.332 1.00 40.64 ? 38  LYS A HE3    1 
ATOM   378  H  HZ1    . LYS A 1 38  ? 306.465 211.397 107.617 1.00 39.51 ? 38  LYS A HZ1    1 
ATOM   379  H  HZ2    . LYS A 1 38  ? 305.076 211.724 107.866 1.00 40.06 ? 38  LYS A HZ2    1 
ATOM   380  H  HZ3    . LYS A 1 38  ? 305.542 211.548 106.508 1.00 40.22 ? 38  LYS A HZ3    1 
ATOM   381  N  N      . LEU A 1 39  ? 307.513 204.838 108.414 1.00 36.59 ? 39  LEU A N      1 
ATOM   382  C  CA     . LEU A 1 39  ? 307.119 204.375 109.738 1.00 35.16 ? 39  LEU A CA     1 
ATOM   383  C  C      . LEU A 1 39  ? 308.215 203.607 110.457 1.00 37.95 ? 39  LEU A C      1 
ATOM   384  O  O      . LEU A 1 39  ? 308.350 203.729 111.677 1.00 41.50 ? 39  LEU A O      1 
ATOM   385  C  CB     . LEU A 1 39  ? 305.888 203.476 109.642 1.00 34.80 ? 39  LEU A CB     1 
ATOM   386  C  CG     . LEU A 1 39  ? 304.683 203.978 108.863 1.00 35.89 ? 39  LEU A CG     1 
ATOM   387  C  CD1    . LEU A 1 39  ? 303.615 202.925 108.875 1.00 34.16 ? 39  LEU A CD1    1 
ATOM   388  C  CD2    . LEU A 1 39  ? 304.165 205.254 109.451 1.00 36.93 ? 39  LEU A CD2    1 
ATOM   389  H  H      . LEU A 1 39  ? 307.489 204.226 107.817 1.00 35.57 ? 39  LEU A H      1 
ATOM   390  H  HA     . LEU A 1 39  ? 306.886 205.138 110.282 1.00 35.28 ? 39  LEU A HA     1 
ATOM   391  H  HB2    . LEU A 1 39  ? 306.163 202.651 109.219 1.00 34.59 ? 39  LEU A HB2    1 
ATOM   392  H  HB3    . LEU A 1 39  ? 305.583 203.289 110.539 1.00 34.96 ? 39  LEU A HB3    1 
ATOM   393  H  HG     . LEU A 1 39  ? 304.938 204.144 107.949 1.00 35.37 ? 39  LEU A HG     1 
ATOM   394  H  HD11   . LEU A 1 39  ? 303.971 202.109 108.497 1.00 33.62 ? 39  LEU A HD11   1 
ATOM   395  H  HD12   . LEU A 1 39  ? 302.863 203.237 108.354 1.00 34.52 ? 39  LEU A HD12   1 
ATOM   396  H  HD13   . LEU A 1 39  ? 303.344 202.775 109.791 1.00 34.71 ? 39  LEU A HD13   1 
ATOM   397  H  HD21   . LEU A 1 39  ? 303.826 205.071 110.338 1.00 36.51 ? 39  LEU A HD21   1 
ATOM   398  H  HD22   . LEU A 1 39  ? 303.452 205.586 108.883 1.00 36.19 ? 39  LEU A HD22   1 
ATOM   399  H  HD23   . LEU A 1 39  ? 304.888 205.897 109.495 1.00 36.80 ? 39  LEU A HD23   1 
ATOM   400  N  N      . GLY A 1 40  ? 308.995 202.819 109.731 1.00 39.38 ? 40  GLY A N      1 
ATOM   401  C  CA     . GLY A 1 40  ? 309.993 201.960 110.314 1.00 36.67 ? 40  GLY A CA     1 
ATOM   402  C  C      . GLY A 1 40  ? 309.534 200.540 110.544 1.00 36.25 ? 40  GLY A C      1 
ATOM   403  O  O      . GLY A 1 40  ? 310.328 199.718 111.015 1.00 37.57 ? 40  GLY A O      1 
ATOM   404  H  H      . GLY A 1 40  ? 308.969 202.777 108.878 1.00 37.11 ? 40  GLY A H      1 
ATOM   405  H  HA2    . GLY A 1 40  ? 310.762 201.933 109.727 1.00 36.97 ? 40  GLY A HA2    1 
ATOM   406  H  HA3    . GLY A 1 40  ? 310.270 202.327 111.164 1.00 36.73 ? 40  GLY A HA3    1 
ATOM   407  N  N      . GLU A 1 41  ? 308.284 200.226 110.223 1.00 40.01 ? 41  GLU A N      1 
ATOM   408  C  CA     . GLU A 1 41  ? 307.728 198.898 110.414 1.00 41.92 ? 41  GLU A CA     1 
ATOM   409  C  C      . GLU A 1 41  ? 307.243 198.335 109.089 1.00 38.15 ? 41  GLU A C      1 
ATOM   410  O  O      . GLU A 1 41  ? 306.900 199.067 108.159 1.00 39.82 ? 41  GLU A O      1 
ATOM   411  C  CB     . GLU A 1 41  ? 306.567 198.905 111.418 1.00 44.50 ? 41  GLU A CB     1 
ATOM   412  C  CG     . GLU A 1 41  ? 305.502 199.955 111.164 1.00 45.99 ? 41  GLU A CG     1 
ATOM   413  C  CD     . GLU A 1 41  ? 304.888 200.489 112.442 1.00 52.90 ? 41  GLU A CD     1 
ATOM   414  O  OE1    . GLU A 1 41  ? 305.605 200.579 113.460 1.00 52.18 ? 41  GLU A OE1    1 
ATOM   415  O  OE2    . GLU A 1 41  ? 303.684 200.816 112.431 1.00 53.03 ? 41  GLU A OE2    1 
ATOM   416  H  H      . GLU A 1 41  ? 307.732 200.779 109.874 1.00 39.65 ? 41  GLU A H      1 
ATOM   417  H  HA     . GLU A 1 41  ? 308.418 198.314 110.757 1.00 41.52 ? 41  GLU A HA     1 
ATOM   418  H  HB2    . GLU A 1 41  ? 306.129 198.043 111.377 1.00 44.03 ? 41  GLU A HB2    1 
ATOM   419  H  HB3    . GLU A 1 41  ? 306.924 199.045 112.306 1.00 44.35 ? 41  GLU A HB3    1 
ATOM   420  H  HG2    . GLU A 1 41  ? 305.888 200.700 110.686 1.00 43.32 ? 41  GLU A HG2    1 
ATOM   421  H  HG3    . GLU A 1 41  ? 304.793 199.557 110.638 1.00 45.25 ? 41  GLU A HG3    1 
ATOM   422  N  N      . VAL A 1 42  ? 307.205 197.011 109.022 1.00 38.07 ? 42  VAL A N      1 
ATOM   423  C  CA     . VAL A 1 42  ? 306.722 196.294 107.850 1.00 38.79 ? 42  VAL A CA     1 
ATOM   424  C  C      . VAL A 1 42  ? 305.219 196.103 107.966 1.00 39.23 ? 42  VAL A C      1 
ATOM   425  O  O      . VAL A 1 42  ? 304.744 195.324 108.801 1.00 40.99 ? 42  VAL A O      1 
ATOM   426  C  CB     . VAL A 1 42  ? 307.434 194.943 107.710 1.00 38.82 ? 42  VAL A CB     1 
ATOM   427  C  CG1    . VAL A 1 42  ? 306.806 194.128 106.614 1.00 35.47 ? 42  VAL A CG1    1 
ATOM   428  C  CG2    . VAL A 1 42  ? 308.888 195.164 107.433 1.00 37.43 ? 42  VAL A CG2    1 
ATOM   429  H  H      . VAL A 1 42  ? 307.467 196.497 109.657 1.00 38.96 ? 42  VAL A H      1 
ATOM   430  H  HA     . VAL A 1 42  ? 306.903 196.817 107.058 1.00 38.42 ? 42  VAL A HA     1 
ATOM   431  H  HB     . VAL A 1 42  ? 307.349 194.456 108.539 1.00 39.33 ? 42  VAL A HB     1 
ATOM   432  H  HG11   . VAL A 1 42  ? 307.487 193.582 106.202 1.00 36.35 ? 42  VAL A HG11   1 
ATOM   433  H  HG12   . VAL A 1 42  ? 306.413 194.722 105.962 1.00 36.04 ? 42  VAL A HG12   1 
ATOM   434  H  HG13   . VAL A 1 42  ? 306.129 193.557 106.999 1.00 36.68 ? 42  VAL A HG13   1 
ATOM   435  H  HG21   . VAL A 1 42  ? 309.412 194.569 107.991 1.00 37.58 ? 42  VAL A HG21   1 
ATOM   436  H  HG22   . VAL A 1 42  ? 309.102 196.086 107.632 1.00 37.17 ? 42  VAL A HG22   1 
ATOM   437  H  HG23   . VAL A 1 42  ? 309.050 194.986 106.498 1.00 37.69 ? 42  VAL A HG23   1 
ATOM   438  N  N      . ILE A 1 43  ? 304.470 196.806 107.127 1.00 37.26 ? 43  ILE A N      1 
ATOM   439  C  CA     . ILE A 1 43  ? 303.022 196.752 107.159 1.00 34.64 ? 43  ILE A CA     1 
ATOM   440  C  C      . ILE A 1 43  ? 302.541 195.655 106.224 1.00 33.39 ? 43  ILE A C      1 
ATOM   441  O  O      . ILE A 1 43  ? 303.212 195.278 105.259 1.00 36.24 ? 43  ILE A O      1 
ATOM   442  C  CB     . ILE A 1 43  ? 302.386 198.105 106.786 1.00 32.49 ? 43  ILE A CB     1 
ATOM   443  C  CG1    . ILE A 1 43  ? 302.617 198.450 105.320 1.00 32.35 ? 43  ILE A CG1    1 
ATOM   444  C  CG2    . ILE A 1 43  ? 302.937 199.206 107.644 1.00 33.17 ? 43  ILE A CG2    1 
ATOM   445  C  CD1    . ILE A 1 43  ? 301.689 199.498 104.838 1.00 34.18 ? 43  ILE A CD1    1 
ATOM   446  H  H      . ILE A 1 43  ? 304.778 197.334 106.526 1.00 36.71 ? 43  ILE A H      1 
ATOM   447  H  HA     . ILE A 1 43  ? 302.740 196.523 108.050 1.00 36.04 ? 43  ILE A HA     1 
ATOM   448  H  HB     . ILE A 1 43  ? 301.434 198.046 106.933 1.00 33.55 ? 43  ILE A HB     1 
ATOM   449  H  HG12   . ILE A 1 43  ? 303.520 198.776 105.210 1.00 33.13 ? 43  ILE A HG12   1 
ATOM   450  H  HG13   . ILE A 1 43  ? 302.485 197.671 104.765 1.00 33.06 ? 43  ILE A HG13   1 
ATOM   451  H  HG21   . ILE A 1 43  ? 303.550 199.733 107.116 1.00 34.34 ? 43  ILE A HG21   1 
ATOM   452  H  HG22   . ILE A 1 43  ? 303.394 198.816 108.401 1.00 36.28 ? 43  ILE A HG22   1 
ATOM   453  H  HG23   . ILE A 1 43  ? 302.206 199.761 107.946 1.00 33.90 ? 43  ILE A HG23   1 
ATOM   454  H  HD11   . ILE A 1 43  ? 302.032 199.862 104.010 1.00 34.21 ? 43  ILE A HD11   1 
ATOM   455  H  HD12   . ILE A 1 43  ? 301.635 200.188 105.514 1.00 34.23 ? 43  ILE A HD12   1 
ATOM   456  H  HD13   . ILE A 1 43  ? 300.814 199.108 104.698 1.00 34.03 ? 43  ILE A HD13   1 
ATOM   457  N  N      . THR A 1 44  ? 301.358 195.136 106.524 1.00 36.49 ? 44  THR A N      1 
ATOM   458  C  CA     . THR A 1 44  ? 300.634 194.306 105.579 1.00 33.31 ? 44  THR A CA     1 
ATOM   459  C  C      . THR A 1 44  ? 300.163 195.190 104.439 1.00 34.00 ? 44  THR A C      1 
ATOM   460  O  O      . THR A 1 44  ? 299.989 196.398 104.617 1.00 36.11 ? 44  THR A O      1 
ATOM   461  C  CB     . THR A 1 44  ? 299.455 193.618 106.255 1.00 35.43 ? 44  THR A CB     1 
ATOM   462  O  OG1    . THR A 1 44  ? 299.936 192.685 107.227 1.00 37.50 ? 44  THR A OG1    1 
ATOM   463  C  CG2    . THR A 1 44  ? 298.629 192.888 105.250 1.00 36.59 ? 44  THR A CG2    1 
ATOM   464  H  H      . THR A 1 44  ? 300.954 195.254 107.268 1.00 36.53 ? 44  THR A H      1 
ATOM   465  H  HA     . THR A 1 44  ? 301.221 193.629 105.221 1.00 34.21 ? 44  THR A HA     1 
ATOM   466  H  HB     . THR A 1 44  ? 298.903 194.285 106.680 1.00 35.82 ? 44  THR A HB     1 
ATOM   467  H  HG1    . THR A 1 44  ? 300.513 192.192 106.871 1.00 35.82 ? 44  THR A HG1    1 
ATOM   468  H  HG21   . THR A 1 44  ? 298.040 192.266 105.701 1.00 37.05 ? 44  THR A HG21   1 
ATOM   469  H  HG22   . THR A 1 44  ? 299.198 192.399 104.635 1.00 36.27 ? 44  THR A HG22   1 
ATOM   470  H  HG23   . THR A 1 44  ? 298.101 193.529 104.753 1.00 35.79 ? 44  THR A HG23   1 
ATOM   471  N  N      . THR A 1 45  ? 299.988 194.602 103.266 1.00 40.21 ? 45  THR A N      1 
ATOM   472  C  CA     . THR A 1 45  ? 299.789 195.378 102.061 1.00 38.76 ? 45  THR A CA     1 
ATOM   473  C  C      . THR A 1 45  ? 298.608 194.859 101.264 1.00 38.01 ? 45  THR A C      1 
ATOM   474  O  O      . THR A 1 45  ? 298.273 193.672 101.284 1.00 37.93 ? 45  THR A O      1 
ATOM   475  C  CB     . THR A 1 45  ? 301.033 195.341 101.174 1.00 38.41 ? 45  THR A CB     1 
ATOM   476  O  OG1    . THR A 1 45  ? 301.641 194.049 101.274 1.00 41.12 ? 45  THR A OG1    1 
ATOM   477  C  CG2    . THR A 1 45  ? 302.018 196.397 101.578 1.00 33.28 ? 45  THR A CG2    1 
ATOM   478  H  H      . THR A 1 45  ? 299.978 193.754 103.139 1.00 38.65 ? 45  THR A H      1 
ATOM   479  H  HA     . THR A 1 45  ? 299.613 196.295 102.302 1.00 37.07 ? 45  THR A HA     1 
ATOM   480  H  HB     . THR A 1 45  ? 300.775 195.516 100.260 1.00 38.33 ? 45  THR A HB     1 
ATOM   481  H  HG1    . THR A 1 45  ? 301.040 193.462 101.316 1.00 39.34 ? 45  THR A HG1    1 
ATOM   482  H  HG21   . THR A 1 45  ? 301.556 197.192 101.881 1.00 34.31 ? 45  THR A HG21   1 
ATOM   483  H  HG22   . THR A 1 45  ? 302.569 196.625 100.816 1.00 33.41 ? 45  THR A HG22   1 
ATOM   484  H  HG23   . THR A 1 45  ? 302.580 196.062 102.289 1.00 34.69 ? 45  THR A HG23   1 
ATOM   485  N  N      . ILE A 1 46  ? 298.003 195.783 100.529 1.00 39.28 ? 46  ILE A N      1 
ATOM   486  C  CA     . ILE A 1 46  ? 296.962 195.467 99.562  1.00 42.32 ? 46  ILE A CA     1 
ATOM   487  C  C      . ILE A 1 46  ? 297.438 195.995 98.218  1.00 43.91 ? 46  ILE A C      1 
ATOM   488  O  O      . ILE A 1 46  ? 298.224 196.951 98.175  1.00 46.45 ? 46  ILE A O      1 
ATOM   489  C  CB     . ILE A 1 46  ? 295.618 196.085 99.961  1.00 41.11 ? 46  ILE A CB     1 
ATOM   490  C  CG1    . ILE A 1 46  ? 295.735 197.607 99.973  1.00 37.92 ? 46  ILE A CG1    1 
ATOM   491  C  CG2    . ILE A 1 46  ? 295.199 195.572 101.317 1.00 39.86 ? 46  ILE A CG2    1 
ATOM   492  C  CD1    . ILE A 1 46  ? 294.496 198.301 100.420 1.00 40.23 ? 46  ILE A CD1    1 
ATOM   493  H  H      . ILE A 1 46  ? 298.189 196.619 100.575 1.00 39.56 ? 46  ILE A H      1 
ATOM   494  H  HA     . ILE A 1 46  ? 296.861 194.507 99.510  1.00 41.28 ? 46  ILE A HA     1 
ATOM   495  H  HB     . ILE A 1 46  ? 294.949 195.828 99.311  1.00 40.93 ? 46  ILE A HB     1 
ATOM   496  H  HG12   . ILE A 1 46  ? 296.456 197.862 100.565 1.00 38.93 ? 46  ILE A HG12   1 
ATOM   497  H  HG13   . ILE A 1 46  ? 295.926 197.917 99.078  1.00 39.69 ? 46  ILE A HG13   1 
ATOM   498  H  HG21   . ILE A 1 46  ? 294.245 195.703 101.415 1.00 40.67 ? 46  ILE A HG21   1 
ATOM   499  H  HG22   . ILE A 1 46  ? 295.676 196.067 101.998 1.00 39.18 ? 46  ILE A HG22   1 
ATOM   500  H  HG23   . ILE A 1 46  ? 295.417 194.628 101.380 1.00 39.94 ? 46  ILE A HG23   1 
ATOM   501  H  HD11   . ILE A 1 46  ? 293.761 197.987 99.873  1.00 41.06 ? 46  ILE A HD11   1 
ATOM   502  H  HD12   . ILE A 1 46  ? 294.607 199.258 100.306 1.00 39.49 ? 46  ILE A HD12   1 
ATOM   503  H  HD13   . ILE A 1 46  ? 294.337 198.094 101.352 1.00 41.27 ? 46  ILE A HD13   1 
ATOM   504  N  N      . PRO A 1 47  ? 297.003 195.422 97.113  1.00 37.52 ? 47  PRO A N      1 
ATOM   505  C  CA     . PRO A 1 47  ? 297.379 195.978 95.816  1.00 35.03 ? 47  PRO A CA     1 
ATOM   506  C  C      . PRO A 1 47  ? 297.049 197.451 95.692  1.00 34.22 ? 47  PRO A C      1 
ATOM   507  O  O      . PRO A 1 47  ? 295.989 197.903 96.130  1.00 37.51 ? 47  PRO A O      1 
ATOM   508  C  CB     . PRO A 1 47  ? 296.564 195.130 94.843  1.00 37.67 ? 47  PRO A CB     1 
ATOM   509  C  CG     . PRO A 1 47  ? 296.498 193.827 95.501  1.00 38.46 ? 47  PRO A CG     1 
ATOM   510  C  CD     . PRO A 1 47  ? 296.405 194.088 96.972  1.00 37.46 ? 47  PRO A CD     1 
ATOM   511  H  HA     . PRO A 1 47  ? 298.319 195.842 95.657  1.00 36.81 ? 47  PRO A HA     1 
ATOM   512  H  HB2    . PRO A 1 47  ? 295.682 195.513 94.740  1.00 38.14 ? 47  PRO A HB2    1 
ATOM   513  H  HB3    . PRO A 1 47  ? 297.027 195.070 93.999  1.00 37.77 ? 47  PRO A HB3    1 
ATOM   514  H  HG2    . PRO A 1 47  ? 295.713 193.353 95.194  1.00 38.45 ? 47  PRO A HG2    1 
ATOM   515  H  HG3    . PRO A 1 47  ? 297.303 193.332 95.300  1.00 38.10 ? 47  PRO A HG3    1 
ATOM   516  H  HD2    . PRO A 1 47  ? 295.483 194.091 97.266  1.00 38.50 ? 47  PRO A HD2    1 
ATOM   517  H  HD3    . PRO A 1 47  ? 296.936 193.440 97.455  1.00 38.18 ? 47  PRO A HD3    1 
ATOM   518  N  N      . THR A 1 48  ? 297.973 198.202 95.109  1.00 33.94 ? 48  THR A N      1 
ATOM   519  C  CA     . THR A 1 48  ? 297.847 199.645 95.012  1.00 33.11 ? 48  THR A CA     1 
ATOM   520  C  C      . THR A 1 48  ? 297.111 200.005 93.733  1.00 36.66 ? 48  THR A C      1 
ATOM   521  O  O      . THR A 1 48  ? 297.694 200.006 92.646  1.00 40.24 ? 48  THR A O      1 
ATOM   522  C  CB     . THR A 1 48  ? 299.224 200.291 95.049  1.00 39.06 ? 48  THR A CB     1 
ATOM   523  O  OG1    . THR A 1 48  ? 300.044 199.574 95.979  1.00 44.80 ? 48  THR A OG1    1 
ATOM   524  C  CG2    . THR A 1 48  ? 299.128 201.728 95.458  1.00 36.19 ? 48  THR A CG2    1 
ATOM   525  H  H      . THR A 1 48  ? 298.689 197.894 94.754  1.00 36.67 ? 48  THR A H      1 
ATOM   526  H  HA     . THR A 1 48  ? 297.341 199.971 95.764  1.00 35.15 ? 48  THR A HA     1 
ATOM   527  H  HB     . THR A 1 48  ? 299.593 200.267 94.160  1.00 38.49 ? 48  THR A HB     1 
ATOM   528  H  HG1    . THR A 1 48  ? 300.818 199.891 96.010  1.00 40.86 ? 48  THR A HG1    1 
ATOM   529  H  HG21   . THR A 1 48  ? 298.318 202.101 95.086  1.00 35.77 ? 48  THR A HG21   1 
ATOM   530  H  HG22   . THR A 1 48  ? 299.893 202.218 95.127  1.00 36.15 ? 48  THR A HG22   1 
ATOM   531  H  HG23   . THR A 1 48  ? 299.101 201.808 96.419  1.00 36.99 ? 48  THR A HG23   1 
ATOM   532  N  N      . ILE A 1 49  ? 295.826 200.302 93.870  1.00 36.97 ? 49  ILE A N      1 
ATOM   533  C  CA     . ILE A 1 49  ? 294.970 200.668 92.754  1.00 33.15 ? 49  ILE A CA     1 
ATOM   534  C  C      . ILE A 1 49  ? 295.151 202.147 92.458  1.00 30.54 ? 49  ILE A C      1 
ATOM   535  O  O      . ILE A 1 49  ? 295.215 202.557 91.296  1.00 35.14 ? 49  ILE A O      1 
ATOM   536  C  CB     . ILE A 1 49  ? 293.499 200.351 93.059  1.00 28.81 ? 49  ILE A CB     1 
ATOM   537  C  CG1    . ILE A 1 49  ? 293.323 198.883 93.442  1.00 32.90 ? 49  ILE A CG1    1 
ATOM   538  C  CG2    . ILE A 1 49  ? 292.655 200.674 91.885  1.00 30.05 ? 49  ILE A CG2    1 
ATOM   539  C  CD1    . ILE A 1 49  ? 293.865 197.904 92.439  1.00 35.97 ? 49  ILE A CD1    1 
ATOM   540  H  H      . ILE A 1 49  ? 295.420 200.301 94.624  1.00 35.66 ? 49  ILE A H      1 
ATOM   541  H  HA     . ILE A 1 49  ? 295.231 200.174 91.967  1.00 34.01 ? 49  ILE A HA     1 
ATOM   542  H  HB     . ILE A 1 49  ? 293.223 200.902 93.799  1.00 30.76 ? 49  ILE A HB     1 
ATOM   543  H  HG12   . ILE A 1 49  ? 293.766 198.725 94.287  1.00 33.64 ? 49  ILE A HG12   1 
ATOM   544  H  HG13   . ILE A 1 49  ? 292.376 198.711 93.534  1.00 32.44 ? 49  ILE A HG13   1 
ATOM   545  H  HG21   . ILE A 1 49  ? 291.737 200.459 92.095  1.00 30.85 ? 49  ILE A HG21   1 
ATOM   546  H  HG22   . ILE A 1 49  ? 292.963 200.145 91.138  1.00 32.55 ? 49  ILE A HG22   1 
ATOM   547  H  HG23   . ILE A 1 49  ? 292.746 201.616 91.689  1.00 30.40 ? 49  ILE A HG23   1 
ATOM   548  H  HD11   . ILE A 1 49  ? 293.781 197.010 92.801  1.00 35.18 ? 49  ILE A HD11   1 
ATOM   549  H  HD12   . ILE A 1 49  ? 294.795 198.094 92.259  1.00 34.26 ? 49  ILE A HD12   1 
ATOM   550  H  HD13   . ILE A 1 49  ? 293.355 197.987 91.623  1.00 35.18 ? 49  ILE A HD13   1 
ATOM   551  N  N      . GLY A 1 50  ? 295.223 202.953 93.505  1.00 26.69 ? 50  GLY A N      1 
ATOM   552  C  CA     . GLY A 1 50  ? 295.380 204.379 93.330  1.00 28.45 ? 50  GLY A CA     1 
ATOM   553  C  C      . GLY A 1 50  ? 296.814 204.833 93.454  1.00 34.55 ? 50  GLY A C      1 
ATOM   554  O  O      . GLY A 1 50  ? 297.649 204.545 92.593  1.00 45.49 ? 50  GLY A O      1 
ATOM   555  H  H      . GLY A 1 50  ? 295.185 202.695 94.321  1.00 30.53 ? 50  GLY A H      1 
ATOM   556  H  HA2    . GLY A 1 50  ? 295.057 204.628 92.453  1.00 31.82 ? 50  GLY A HA2    1 
ATOM   557  H  HA3    . GLY A 1 50  ? 294.861 204.842 94.003  1.00 29.31 ? 50  GLY A HA3    1 
ATOM   558  N  N      . PHE A 1 51  ? 297.105 205.560 94.525  1.00 31.83 ? 51  PHE A N      1 
ATOM   559  C  CA     . PHE A 1 51  ? 298.453 206.032 94.776  1.00 39.23 ? 51  PHE A CA     1 
ATOM   560  C  C      . PHE A 1 51  ? 298.588 206.378 96.246  1.00 42.28 ? 51  PHE A C      1 
ATOM   561  O  O      . PHE A 1 51  ? 297.609 206.738 96.901  1.00 45.36 ? 51  PHE A O      1 
ATOM   562  C  CB     . PHE A 1 51  ? 298.793 207.249 93.914  1.00 37.57 ? 51  PHE A CB     1 
ATOM   563  C  CG     . PHE A 1 51  ? 298.145 208.517 94.368  1.00 41.82 ? 51  PHE A CG     1 
ATOM   564  C  CD1    . PHE A 1 51  ? 296.932 208.908 93.853  1.00 40.50 ? 51  PHE A CD1    1 
ATOM   565  C  CD2    . PHE A 1 51  ? 298.757 209.327 95.300  1.00 40.29 ? 51  PHE A CD2    1 
ATOM   566  C  CE1    . PHE A 1 51  ? 296.338 210.072 94.268  1.00 39.80 ? 51  PHE A CE1    1 
ATOM   567  C  CE2    . PHE A 1 51  ? 298.162 210.494 95.715  1.00 38.72 ? 51  PHE A CE2    1 
ATOM   568  C  CZ     . PHE A 1 51  ? 296.953 210.863 95.196  1.00 38.61 ? 51  PHE A CZ     1 
ATOM   569  H  H      . PHE A 1 51  ? 296.540 205.786 95.126  1.00 34.35 ? 51  PHE A H      1 
ATOM   570  H  HA     . PHE A 1 51  ? 299.077 205.327 94.569  1.00 38.96 ? 51  PHE A HA     1 
ATOM   571  H  HB2    . PHE A 1 51  ? 299.750 207.385 93.932  1.00 38.05 ? 51  PHE A HB2    1 
ATOM   572  H  HB3    . PHE A 1 51  ? 298.494 207.077 93.010  1.00 38.46 ? 51  PHE A HB3    1 
ATOM   573  H  HD1    . PHE A 1 51  ? 296.510 208.374 93.223  1.00 39.84 ? 51  PHE A HD1    1 
ATOM   574  H  HD2    . PHE A 1 51  ? 299.577 209.074 95.655  1.00 39.54 ? 51  PHE A HD2    1 
ATOM   575  H  HE1    . PHE A 1 51  ? 295.520 210.325 93.917  1.00 40.28 ? 51  PHE A HE1    1 
ATOM   576  H  HE2    . PHE A 1 51  ? 298.577 211.032 96.346  1.00 38.86 ? 51  PHE A HE2    1 
ATOM   577  H  HZ     . PHE A 1 51  ? 296.551 211.650 95.471  1.00 38.89 ? 51  PHE A HZ     1 
ATOM   578  N  N      . ASN A 1 52  ? 299.805 206.256 96.750  1.00 38.50 ? 52  ASN A N      1 
ATOM   579  C  CA     . ASN A 1 52  ? 300.162 206.688 98.088  1.00 38.20 ? 52  ASN A CA     1 
ATOM   580  C  C      . ASN A 1 52  ? 301.229 207.762 97.981  1.00 38.93 ? 52  ASN A C      1 
ATOM   581  O  O      . ASN A 1 52  ? 302.056 207.739 97.068  1.00 40.49 ? 52  ASN A O      1 
ATOM   582  C  CB     . ASN A 1 52  ? 300.672 205.516 98.922  1.00 37.58 ? 52  ASN A CB     1 
ATOM   583  C  CG     . ASN A 1 52  ? 299.654 204.418 99.065  1.00 46.87 ? 52  ASN A CG     1 
ATOM   584  O  OD1    . ASN A 1 52  ? 298.469 204.674 99.260  1.00 59.18 ? 52  ASN A OD1    1 
ATOM   585  N  ND2    . ASN A 1 52  ? 300.109 203.183 98.962  1.00 43.50 ? 52  ASN A ND2    1 
ATOM   586  H  H      . ASN A 1 52  ? 300.461 205.916 96.323  1.00 39.86 ? 52  ASN A H      1 
ATOM   587  H  HA     . ASN A 1 52  ? 299.386 207.061 98.523  1.00 40.77 ? 52  ASN A HA     1 
ATOM   588  H  HB2    . ASN A 1 52  ? 301.448 205.139 98.490  1.00 39.97 ? 52  ASN A HB2    1 
ATOM   589  H  HB3    . ASN A 1 52  ? 300.900 205.833 99.806  1.00 39.77 ? 52  ASN A HB3    1 
ATOM   590  H  HD21   . ASN A 1 52  ? 300.946 203.044 98.826  1.00 41.01 ? 52  ASN A HD21   1 
ATOM   591  H  HD22   . ASN A 1 52  ? 299.568 202.521 99.034  1.00 43.24 ? 52  ASN A HD22   1 
ATOM   592  N  N      . VAL A 1 53  ? 301.203 208.708 98.907  1.00 40.13 ? 53  VAL A N      1 
ATOM   593  C  CA     . VAL A 1 53  ? 302.142 209.819 98.908  1.00 35.58 ? 53  VAL A CA     1 
ATOM   594  C  C      . VAL A 1 53  ? 302.570 210.067 100.342 1.00 37.17 ? 53  VAL A C      1 
ATOM   595  O  O      . VAL A 1 53  ? 301.727 210.151 101.240 1.00 39.66 ? 53  VAL A O      1 
ATOM   596  C  CB     . VAL A 1 53  ? 301.523 211.082 98.284  1.00 36.84 ? 53  VAL A CB     1 
ATOM   597  C  CG1    . VAL A 1 53  ? 300.170 211.345 98.870  1.00 41.41 ? 53  VAL A CG1    1 
ATOM   598  C  CG2    . VAL A 1 53  ? 302.420 212.264 98.469  1.00 34.92 ? 53  VAL A CG2    1 
ATOM   599  H  H      . VAL A 1 53  ? 300.639 208.735 99.553  1.00 40.43 ? 53  VAL A H      1 
ATOM   600  H  HA     . VAL A 1 53  ? 302.919 209.573 98.394  1.00 36.75 ? 53  VAL A HA     1 
ATOM   601  H  HB     . VAL A 1 53  ? 301.410 210.934 97.337  1.00 37.87 ? 53  VAL A HB     1 
ATOM   602  H  HG11   . VAL A 1 53  ? 299.596 210.600 98.645  1.00 40.26 ? 53  VAL A HG11   1 
ATOM   603  H  HG12   . VAL A 1 53  ? 299.816 212.166 98.494  1.00 40.38 ? 53  VAL A HG12   1 
ATOM   604  H  HG13   . VAL A 1 53  ? 300.257 211.423 99.831  1.00 40.12 ? 53  VAL A HG13   1 
ATOM   605  H  HG21   . VAL A 1 53  ? 302.508 212.448 99.410  1.00 35.85 ? 53  VAL A HG21   1 
ATOM   606  H  HG22   . VAL A 1 53  ? 302.006 213.016 98.025  1.00 35.73 ? 53  VAL A HG22   1 
ATOM   607  H  HG23   . VAL A 1 53  ? 303.285 212.075 98.078  1.00 34.77 ? 53  VAL A HG23   1 
ATOM   608  N  N      . GLU A 1 54  ? 303.876 210.171 100.563 1.00 38.94 ? 54  GLU A N      1 
ATOM   609  C  CA     . GLU A 1 54  ? 304.387 210.335 101.915 1.00 37.89 ? 54  GLU A CA     1 
ATOM   610  C  C      . GLU A 1 54  ? 305.690 211.111 101.894 1.00 38.20 ? 54  GLU A C      1 
ATOM   611  O  O      . GLU A 1 54  ? 306.524 210.916 101.012 1.00 39.80 ? 54  GLU A O      1 
ATOM   612  C  CB     . GLU A 1 54  ? 304.611 208.989 102.601 1.00 38.72 ? 54  GLU A CB     1 
ATOM   613  C  CG     . GLU A 1 54  ? 303.348 208.245 102.938 1.00 44.18 ? 54  GLU A CG     1 
ATOM   614  C  CD     . GLU A 1 54  ? 302.497 208.963 103.958 1.00 54.99 ? 54  GLU A CD     1 
ATOM   615  O  OE1    . GLU A 1 54  ? 301.284 208.675 104.030 1.00 55.98 ? 54  GLU A OE1    1 
ATOM   616  O  OE2    . GLU A 1 54  ? 303.038 209.822 104.687 1.00 50.83 ? 54  GLU A OE2    1 
ATOM   617  H  H      . GLU A 1 54  ? 304.479 210.151 99.957  1.00 39.49 ? 54  GLU A H      1 
ATOM   618  H  HA     . GLU A 1 54  ? 303.753 210.839 102.437 1.00 40.01 ? 54  GLU A HA     1 
ATOM   619  H  HB2    . GLU A 1 54  ? 305.140 208.432 102.015 1.00 38.73 ? 54  GLU A HB2    1 
ATOM   620  H  HB3    . GLU A 1 54  ? 305.087 209.141 103.428 1.00 40.50 ? 54  GLU A HB3    1 
ATOM   621  H  HG2    . GLU A 1 54  ? 302.820 208.152 102.135 1.00 43.09 ? 54  GLU A HG2    1 
ATOM   622  H  HG3    . GLU A 1 54  ? 303.577 207.373 103.292 1.00 41.84 ? 54  GLU A HG3    1 
ATOM   623  N  N      . THR A 1 55  ? 305.854 211.977 102.885 1.00 38.88 ? 55  THR A N      1 
ATOM   624  C  CA     . THR A 1 55  ? 307.061 212.767 103.057 1.00 36.91 ? 55  THR A CA     1 
ATOM   625  C  C      . THR A 1 55  ? 307.928 212.127 104.135 1.00 37.42 ? 55  THR A C      1 
ATOM   626  O  O      . THR A 1 55  ? 307.432 211.786 105.214 1.00 39.96 ? 55  THR A O      1 
ATOM   627  C  CB     . THR A 1 55  ? 306.712 214.206 103.422 1.00 39.23 ? 55  THR A CB     1 
ATOM   628  O  OG1    . THR A 1 55  ? 306.053 214.840 102.320 1.00 40.52 ? 55  THR A OG1    1 
ATOM   629  C  CG2    . THR A 1 55  ? 307.949 214.981 103.747 1.00 41.37 ? 55  THR A CG2    1 
ATOM   630  H  H      . THR A 1 55  ? 305.260 212.138 103.479 1.00 39.56 ? 55  THR A H      1 
ATOM   631  H  HA     . THR A 1 55  ? 307.563 212.773 102.235 1.00 38.00 ? 55  THR A HA     1 
ATOM   632  H  HB     . THR A 1 55  ? 306.130 214.208 104.193 1.00 39.38 ? 55  THR A HB     1 
ATOM   633  H  HG1    . THR A 1 55  ? 305.985 215.663 102.472 1.00 39.33 ? 55  THR A HG1    1 
ATOM   634  H  HG21   . THR A 1 55  ? 307.717 215.901 103.938 1.00 41.52 ? 55  THR A HG21   1 
ATOM   635  H  HG22   . THR A 1 55  ? 308.381 214.596 104.520 1.00 40.16 ? 55  THR A HG22   1 
ATOM   636  H  HG23   . THR A 1 55  ? 308.557 214.961 102.995 1.00 38.92 ? 55  THR A HG23   1 
ATOM   637  N  N      . VAL A 1 56  ? 309.216 211.980 103.844 1.00 37.14 ? 56  VAL A N      1 
ATOM   638  C  CA     . VAL A 1 56  ? 310.186 211.393 104.761 1.00 39.80 ? 56  VAL A CA     1 
ATOM   639  C  C      . VAL A 1 56  ? 311.385 212.325 104.835 1.00 42.03 ? 56  VAL A C      1 
ATOM   640  O  O      . VAL A 1 56  ? 311.844 212.842 103.809 1.00 44.76 ? 56  VAL A O      1 
ATOM   641  C  CB     . VAL A 1 56  ? 310.597 209.972 104.327 1.00 37.75 ? 56  VAL A CB     1 
ATOM   642  C  CG1    . VAL A 1 56  ? 309.532 209.344 103.469 1.00 37.51 ? 56  VAL A CG1    1 
ATOM   643  C  CG2    . VAL A 1 56  ? 311.901 209.963 103.591 1.00 38.46 ? 56  VAL A CG2    1 
ATOM   644  H  H      . VAL A 1 56  ? 309.561 212.228 103.101 1.00 38.14 ? 56  VAL A H      1 
ATOM   645  H  HA     . VAL A 1 56  ? 309.791 211.336 105.640 1.00 39.75 ? 56  VAL A HA     1 
ATOM   646  H  HB     . VAL A 1 56  ? 310.709 209.425 105.113 1.00 37.57 ? 56  VAL A HB     1 
ATOM   647  H  HG11   . VAL A 1 56  ? 308.675 209.457 103.899 1.00 37.76 ? 56  VAL A HG11   1 
ATOM   648  H  HG12   . VAL A 1 56  ? 309.731 208.403 103.355 1.00 36.45 ? 56  VAL A HG12   1 
ATOM   649  H  HG13   . VAL A 1 56  ? 309.539 209.781 102.608 1.00 38.34 ? 56  VAL A HG13   1 
ATOM   650  H  HG21   . VAL A 1 56  ? 311.847 210.584 102.855 1.00 40.52 ? 56  VAL A HG21   1 
ATOM   651  H  HG22   . VAL A 1 56  ? 312.046 209.066 103.257 1.00 37.50 ? 56  VAL A HG22   1 
ATOM   652  H  HG23   . VAL A 1 56  ? 312.615 210.201 104.197 1.00 38.14 ? 56  VAL A HG23   1 
ATOM   653  N  N      . GLN A 1 57  ? 311.870 212.590 106.038 1.00 44.80 ? 57  GLN A N      1 
ATOM   654  C  CA     . GLN A 1 57  ? 312.981 213.532 106.252 1.00 44.61 ? 57  GLN A CA     1 
ATOM   655  C  C      . GLN A 1 57  ? 314.256 212.743 106.469 1.00 47.61 ? 57  GLN A C      1 
ATOM   656  O  O      . GLN A 1 57  ? 314.179 211.697 107.100 1.00 50.58 ? 57  GLN A O      1 
ATOM   657  C  CB     . GLN A 1 57  ? 312.637 214.437 107.421 1.00 45.52 ? 57  GLN A CB     1 
ATOM   658  C  CG     . GLN A 1 57  ? 311.980 215.741 107.004 1.00 47.57 ? 57  GLN A CG     1 
ATOM   659  C  CD     . GLN A 1 57  ? 312.924 216.919 107.028 1.00 55.86 ? 57  GLN A CD     1 
ATOM   660  O  OE1    . GLN A 1 57  ? 312.510 218.064 106.882 1.00 51.38 ? 57  GLN A OE1    1 
ATOM   661  N  NE2    . GLN A 1 57  ? 314.206 216.652 107.211 1.00 59.83 ? 57  GLN A NE2    1 
ATOM   662  H  H      . GLN A 1 57  ? 311.567 212.188 106.797 1.00 44.22 ? 57  GLN A H      1 
ATOM   663  H  HA     . GLN A 1 57  ? 313.082 214.082 105.446 1.00 44.84 ? 57  GLN A HA     1 
ATOM   664  H  HB2    . GLN A 1 57  ? 312.030 213.952 108.018 1.00 46.07 ? 57  GLN A HB2    1 
ATOM   665  H  HB3    . GLN A 1 57  ? 313.455 214.626 107.922 1.00 47.21 ? 57  GLN A HB3    1 
ATOM   666  H  HG2    . GLN A 1 57  ? 311.621 215.641 106.096 1.00 46.15 ? 57  GLN A HG2    1 
ATOM   667  H  HG3    . GLN A 1 57  ? 311.226 215.927 107.603 1.00 48.36 ? 57  GLN A HG3    1 
ATOM   668  H  HE21   . GLN A 1 57  ? 314.677 217.119 107.795 1.00 57.01 ? 57  GLN A HE21   1 
ATOM   669  H  HE22   . GLN A 1 57  ? 314.593 216.002 106.752 1.00 58.33 ? 57  GLN A HE22   1 
ATOM   670  N  N      . TYR A 1 58  ? 315.382 213.240 105.993 1.00 47.52 ? 58  TYR A N      1 
ATOM   671  C  CA     . TYR A 1 58  ? 316.681 212.588 106.048 1.00 46.42 ? 58  TYR A CA     1 
ATOM   672  C  C      . TYR A 1 58  ? 317.733 213.571 105.558 1.00 50.91 ? 58  TYR A C      1 
ATOM   673  O  O      . TYR A 1 58  ? 317.580 214.167 104.490 1.00 51.40 ? 58  TYR A O      1 
ATOM   674  C  CB     . TYR A 1 58  ? 316.690 211.314 105.200 1.00 42.83 ? 58  TYR A CB     1 
ATOM   675  C  CG     . TYR A 1 58  ? 317.980 210.539 105.254 1.00 42.09 ? 58  TYR A CG     1 
ATOM   676  C  CD1    . TYR A 1 58  ? 318.230 209.651 106.281 1.00 43.55 ? 58  TYR A CD1    1 
ATOM   677  C  CD2    . TYR A 1 58  ? 318.939 210.685 104.272 1.00 41.78 ? 58  TYR A CD2    1 
ATOM   678  C  CE1    . TYR A 1 58  ? 319.401 208.939 106.335 1.00 44.31 ? 58  TYR A CE1    1 
ATOM   679  C  CE2    . TYR A 1 58  ? 320.113 209.978 104.320 1.00 44.04 ? 58  TYR A CE2    1 
ATOM   680  C  CZ     . TYR A 1 58  ? 320.338 209.105 105.353 1.00 44.59 ? 58  TYR A CZ     1 
ATOM   681  O  OH     . TYR A 1 58  ? 321.511 208.394 105.407 1.00 47.41 ? 58  TYR A OH     1 
ATOM   682  H  H      . TYR A 1 58  ? 315.407 214.010 105.615 1.00 47.97 ? 58  TYR A H      1 
ATOM   683  H  HA     . TYR A 1 58  ? 316.883 212.344 106.959 1.00 46.10 ? 58  TYR A HA     1 
ATOM   684  H  HB2    . TYR A 1 58  ? 315.987 210.733 105.517 1.00 44.14 ? 58  TYR A HB2    1 
ATOM   685  H  HB3    . TYR A 1 58  ? 316.531 211.551 104.278 1.00 44.67 ? 58  TYR A HB3    1 
ATOM   686  H  HD1    . TYR A 1 58  ? 317.595 209.540 106.945 1.00 44.67 ? 58  TYR A HD1    1 
ATOM   687  H  HD2    . TYR A 1 58  ? 318.790 211.275 103.574 1.00 43.07 ? 58  TYR A HD2    1 
ATOM   688  H  HE1    . TYR A 1 58  ? 319.561 208.348 107.031 1.00 44.49 ? 58  TYR A HE1    1 
ATOM   689  H  HE2    . TYR A 1 58  ? 320.749 210.089 103.657 1.00 45.22 ? 58  TYR A HE2    1 
ATOM   690  H  HH     . TYR A 1 58  ? 321.538 207.936 106.109 1.00 46.26 ? 58  TYR A HH     1 
ATOM   691  N  N      . LYS A 1 59  ? 318.788 213.750 106.350 1.00 50.71 ? 59  LYS A N      1 
ATOM   692  C  CA     . LYS A 1 59  ? 319.895 214.641 106.012 1.00 50.79 ? 59  LYS A CA     1 
ATOM   693  C  C      . LYS A 1 59  ? 319.430 216.068 105.769 1.00 52.00 ? 59  LYS A C      1 
ATOM   694  O  O      . LYS A 1 59  ? 319.955 216.756 104.891 1.00 53.61 ? 59  LYS A O      1 
ATOM   695  C  CB     . LYS A 1 59  ? 320.664 214.133 104.789 1.00 51.26 ? 59  LYS A CB     1 
ATOM   696  C  CG     . LYS A 1 59  ? 321.641 213.020 105.084 1.00 52.81 ? 59  LYS A CG     1 
ATOM   697  C  CD     . LYS A 1 59  ? 322.241 212.463 103.803 1.00 53.00 ? 59  LYS A CD     1 
ATOM   698  C  CE     . LYS A 1 59  ? 323.348 213.344 103.259 1.00 51.61 ? 59  LYS A CE     1 
ATOM   699  N  NZ     . LYS A 1 59  ? 324.664 213.019 103.867 1.00 53.62 ? 59  LYS A NZ     1 
ATOM   700  H  H      . LYS A 1 59  ? 318.882 213.370 107.115 1.00 48.74 ? 59  LYS A H      1 
ATOM   701  H  HA     . LYS A 1 59  ? 320.516 214.657 106.754 1.00 50.35 ? 59  LYS A HA     1 
ATOM   702  H  HB2    . LYS A 1 59  ? 320.028 213.802 104.140 1.00 50.25 ? 59  LYS A HB2    1 
ATOM   703  H  HB3    . LYS A 1 59  ? 321.168 214.865 104.405 1.00 51.35 ? 59  LYS A HB3    1 
ATOM   704  H  HG2    . LYS A 1 59  ? 322.360 213.367 105.632 1.00 52.36 ? 59  LYS A HG2    1 
ATOM   705  H  HG3    . LYS A 1 59  ? 321.184 212.304 105.550 1.00 49.49 ? 59  LYS A HG3    1 
ATOM   706  H  HD2    . LYS A 1 59  ? 322.614 211.589 103.984 1.00 51.04 ? 59  LYS A HD2    1 
ATOM   707  H  HD3    . LYS A 1 59  ? 321.551 212.399 103.127 1.00 51.61 ? 59  LYS A HD3    1 
ATOM   708  H  HE2    . LYS A 1 59  ? 323.415 213.216 102.300 1.00 50.56 ? 59  LYS A HE2    1 
ATOM   709  H  HE3    . LYS A 1 59  ? 323.146 214.270 103.459 1.00 52.87 ? 59  LYS A HE3    1 
ATOM   710  H  HZ1    . LYS A 1 59  ? 325.287 213.570 103.554 1.00 53.47 ? 59  LYS A HZ1    1 
ATOM   711  H  HZ2    . LYS A 1 59  ? 324.620 213.103 104.751 1.00 54.64 ? 59  LYS A HZ2    1 
ATOM   712  H  HZ3    . LYS A 1 59  ? 324.891 212.184 103.666 1.00 52.93 ? 59  LYS A HZ3    1 
ATOM   713  N  N      . ASN A 1 60  ? 318.465 216.542 106.549 1.00 50.61 ? 60  ASN A N      1 
ATOM   714  C  CA     . ASN A 1 60  ? 317.874 217.860 106.386 1.00 49.47 ? 60  ASN A CA     1 
ATOM   715  C  C      . ASN A 1 60  ? 317.191 218.023 105.038 1.00 53.46 ? 60  ASN A C      1 
ATOM   716  O  O      . ASN A 1 60  ? 317.094 219.142 104.527 1.00 58.48 ? 60  ASN A O      1 
ATOM   717  C  CB     . ASN A 1 60  ? 318.909 218.975 106.563 1.00 52.27 ? 60  ASN A CB     1 
ATOM   718  C  CG     . ASN A 1 60  ? 319.942 218.658 107.621 1.00 62.80 ? 60  ASN A CG     1 
ATOM   719  O  OD1    . ASN A 1 60  ? 320.719 217.714 107.494 1.00 63.49 ? 60  ASN A OD1    1 
ATOM   720  N  ND2    . ASN A 1 60  ? 319.965 219.462 108.675 1.00 65.61 ? 60  ASN A ND2    1 
ATOM   721  H  H      . ASN A 1 60  ? 318.127 216.098 107.201 1.00 51.66 ? 60  ASN A H      1 
ATOM   722  H  HA     . ASN A 1 60  ? 317.197 217.978 107.065 1.00 51.81 ? 60  ASN A HA     1 
ATOM   723  H  HB2    . ASN A 1 60  ? 319.360 219.139 105.720 1.00 53.77 ? 60  ASN A HB2    1 
ATOM   724  H  HB3    . ASN A 1 60  ? 318.446 219.770 106.854 1.00 54.18 ? 60  ASN A HB3    1 
ATOM   725  H  HD21   . ASN A 1 60  ? 319.407 220.114 108.734 1.00 62.69 ? 60  ASN A HD21   1 
ATOM   726  H  HD22   . ASN A 1 60  ? 320.534 219.325 109.304 1.00 63.39 ? 60  ASN A HD22   1 
ATOM   727  N  N      . ILE A 1 61  ? 316.710 216.933 104.449 1.00 50.66 ? 61  ILE A N      1 
ATOM   728  C  CA     . ILE A 1 61  ? 316.014 216.956 103.172 1.00 44.86 ? 61  ILE A CA     1 
ATOM   729  C  C      . ILE A 1 61  ? 314.687 216.241 103.353 1.00 44.37 ? 61  ILE A C      1 
ATOM   730  O  O      . ILE A 1 61  ? 314.608 215.231 104.058 1.00 48.53 ? 61  ILE A O      1 
ATOM   731  C  CB     . ILE A 1 61  ? 316.837 216.292 102.054 1.00 44.24 ? 61  ILE A CB     1 
ATOM   732  C  CG1    . ILE A 1 61  ? 318.262 216.823 102.050 1.00 47.81 ? 61  ILE A CG1    1 
ATOM   733  C  CG2    . ILE A 1 61  ? 316.218 216.564 100.717 1.00 49.50 ? 61  ILE A CG2    1 
ATOM   734  C  CD1    . ILE A 1 61  ? 319.147 216.111 101.094 1.00 47.83 ? 61  ILE A CD1    1 
ATOM   735  H  H      . ILE A 1 61  ? 316.783 216.146 104.779 1.00 50.12 ? 61  ILE A H      1 
ATOM   736  H  HA     . ILE A 1 61  ? 315.837 217.869 102.917 1.00 49.27 ? 61  ILE A HA     1 
ATOM   737  H  HB     . ILE A 1 61  ? 316.854 215.339 102.204 1.00 46.64 ? 61  ILE A HB     1 
ATOM   738  H  HG12   . ILE A 1 61  ? 318.246 217.757 101.800 1.00 49.45 ? 61  ILE A HG12   1 
ATOM   739  H  HG13   . ILE A 1 61  ? 318.643 216.721 102.931 1.00 49.38 ? 61  ILE A HG13   1 
ATOM   740  H  HG21   . ILE A 1 61  ? 316.575 215.933 100.076 1.00 49.56 ? 61  ILE A HG21   1 
ATOM   741  H  HG22   . ILE A 1 61  ? 316.442 217.465 100.451 1.00 51.24 ? 61  ILE A HG22   1 
ATOM   742  H  HG23   . ILE A 1 61  ? 315.259 216.468 100.787 1.00 51.04 ? 61  ILE A HG23   1 
ATOM   743  H  HD11   . ILE A 1 61  ? 320.069 216.318 101.307 1.00 48.64 ? 61  ILE A HD11   1 
ATOM   744  H  HD12   . ILE A 1 61  ? 318.935 216.402 100.194 1.00 48.32 ? 61  ILE A HD12   1 
ATOM   745  H  HD13   . ILE A 1 61  ? 318.991 215.160 101.183 1.00 48.47 ? 61  ILE A HD13   1 
ATOM   746  N  N      . SER A 1 62  ? 313.645 216.764 102.720 1.00 40.93 ? 62  SER A N      1 
ATOM   747  C  CA     . SER A 1 62  ? 312.294 216.231 102.857 1.00 45.41 ? 62  SER A CA     1 
ATOM   748  C  C      . SER A 1 62  ? 311.876 215.657 101.513 1.00 43.31 ? 62  SER A C      1 
ATOM   749  O  O      . SER A 1 62  ? 311.383 216.378 100.644 1.00 47.89 ? 62  SER A O      1 
ATOM   750  C  CB     . SER A 1 62  ? 311.324 217.307 103.322 1.00 47.86 ? 62  SER A CB     1 
ATOM   751  O  OG     . SER A 1 62  ? 310.596 217.835 102.233 1.00 52.02 ? 62  SER A OG     1 
ATOM   752  H  H      . SER A 1 62  ? 313.698 217.430 102.188 1.00 46.48 ? 62  SER A H      1 
ATOM   753  H  HA     . SER A 1 62  ? 312.291 215.521 103.508 1.00 47.09 ? 62  SER A HA     1 
ATOM   754  H  HB2    . SER A 1 62  ? 310.700 216.918 103.950 1.00 47.81 ? 62  SER A HB2    1 
ATOM   755  H  HB3    . SER A 1 62  ? 311.826 218.014 103.750 1.00 49.08 ? 62  SER A HB3    1 
ATOM   756  H  HG     . SER A 1 62  ? 310.050 218.410 102.508 1.00 53.13 ? 62  SER A HG     1 
ATOM   757  N  N      . PHE A 1 63  ? 312.077 214.356 101.340 1.00 38.32 ? 63  PHE A N      1 
ATOM   758  C  CA     . PHE A 1 63  ? 311.682 213.664 100.124 1.00 37.36 ? 63  PHE A CA     1 
ATOM   759  C  C      . PHE A 1 63  ? 310.178 213.447 100.161 1.00 41.29 ? 63  PHE A C      1 
ATOM   760  O  O      . PHE A 1 63  ? 309.629 213.028 101.182 1.00 45.15 ? 63  PHE A O      1 
ATOM   761  C  CB     . PHE A 1 63  ? 312.421 212.339 99.993  1.00 34.09 ? 63  PHE A CB     1 
ATOM   762  C  CG     . PHE A 1 63  ? 313.909 212.461 100.075 1.00 35.19 ? 63  PHE A CG     1 
ATOM   763  C  CD1    . PHE A 1 63  ? 314.550 212.435 101.288 1.00 37.65 ? 63  PHE A CD1    1 
ATOM   764  C  CD2    . PHE A 1 63  ? 314.667 212.585 98.935  1.00 36.55 ? 63  PHE A CD2    1 
ATOM   765  C  CE1    . PHE A 1 63  ? 315.913 212.539 101.361 1.00 38.74 ? 63  PHE A CE1    1 
ATOM   766  C  CE2    . PHE A 1 63  ? 316.026 212.689 99.009  1.00 34.79 ? 63  PHE A CE2    1 
ATOM   767  C  CZ     . PHE A 1 63  ? 316.649 212.667 100.222 1.00 33.56 ? 63  PHE A CZ     1 
ATOM   768  H  H      . PHE A 1 63  ? 312.444 213.842 101.917 1.00 40.39 ? 63  PHE A H      1 
ATOM   769  H  HA     . PHE A 1 63  ? 311.896 214.213 99.362  1.00 40.54 ? 63  PHE A HA     1 
ATOM   770  H  HB2    . PHE A 1 63  ? 312.133 211.759 100.709 1.00 36.46 ? 63  PHE A HB2    1 
ATOM   771  H  HB3    . PHE A 1 63  ? 312.207 211.949 99.138  1.00 37.17 ? 63  PHE A HB3    1 
ATOM   772  H  HD1    . PHE A 1 63  ? 314.052 212.349 102.063 1.00 39.59 ? 63  PHE A HD1    1 
ATOM   773  H  HD2    . PHE A 1 63  ? 314.249 212.599 98.109  1.00 37.96 ? 63  PHE A HD2    1 
ATOM   774  H  HE1    . PHE A 1 63  ? 316.337 212.524 102.183 1.00 41.50 ? 63  PHE A HE1    1 
ATOM   775  H  HE2    . PHE A 1 63  ? 316.526 212.776 98.235  1.00 37.07 ? 63  PHE A HE2    1 
ATOM   776  H  HZ     . PHE A 1 63  ? 317.572 212.738 100.273 1.00 36.46 ? 63  PHE A HZ     1 
ATOM   777  N  N      . THR A 1 64  ? 309.513 213.724 99.047  1.00 36.18 ? 64  THR A N      1 
ATOM   778  C  CA     . THR A 1 64  ? 308.078 213.500 98.906  1.00 35.76 ? 64  THR A CA     1 
ATOM   779  C  C      . THR A 1 64  ? 307.882 212.387 97.888  1.00 39.62 ? 64  THR A C      1 
ATOM   780  O  O      . THR A 1 64  ? 307.953 212.614 96.681  1.00 43.90 ? 64  THR A O      1 
ATOM   781  C  CB     . THR A 1 64  ? 307.374 214.781 98.484  1.00 38.29 ? 64  THR A CB     1 
ATOM   782  O  OG1    . THR A 1 64  ? 307.694 215.836 99.398  1.00 42.70 ? 64  THR A OG1    1 
ATOM   783  C  CG2    . THR A 1 64  ? 305.889 214.580 98.457  1.00 38.85 ? 64  THR A CG2    1 
ATOM   784  H  H      . THR A 1 64  ? 309.880 214.037 98.342  1.00 38.98 ? 64  THR A H      1 
ATOM   785  H  HA     . THR A 1 64  ? 307.706 213.214 99.746  1.00 38.36 ? 64  THR A HA     1 
ATOM   786  H  HB     . THR A 1 64  ? 307.665 215.025 97.599  1.00 39.70 ? 64  THR A HB     1 
ATOM   787  H  HG1    . THR A 1 64  ? 308.514 215.997 99.364  1.00 41.58 ? 64  THR A HG1    1 
ATOM   788  H  HG21   . THR A 1 64  ? 305.437 215.436 98.477  1.00 38.74 ? 64  THR A HG21   1 
ATOM   789  H  HG22   . THR A 1 64  ? 305.628 214.064 99.230  1.00 39.03 ? 64  THR A HG22   1 
ATOM   790  H  HG23   . THR A 1 64  ? 305.633 214.104 97.654  1.00 38.73 ? 64  THR A HG23   1 
ATOM   791  N  N      . VAL A 1 65  ? 307.635 211.178 98.377  1.00 36.76 ? 65  VAL A N      1 
ATOM   792  C  CA     . VAL A 1 65  ? 307.612 209.986 97.544  1.00 34.74 ? 65  VAL A CA     1 
ATOM   793  C  C      . VAL A 1 65  ? 306.177 209.680 97.145  1.00 35.55 ? 65  VAL A C      1 
ATOM   794  O  O      . VAL A 1 65  ? 305.258 209.745 97.972  1.00 39.33 ? 65  VAL A O      1 
ATOM   795  C  CB     . VAL A 1 65  ? 308.249 208.795 98.276  1.00 30.51 ? 65  VAL A CB     1 
ATOM   796  C  CG1    . VAL A 1 65  ? 308.376 207.613 97.350  1.00 32.46 ? 65  VAL A CG1    1 
ATOM   797  C  CG2    . VAL A 1 65  ? 309.606 209.169 98.842  1.00 30.57 ? 65  VAL A CG2    1 
ATOM   798  H  H      . VAL A 1 65  ? 307.477 211.016 99.202  1.00 37.19 ? 65  VAL A H      1 
ATOM   799  H  HA     . VAL A 1 65  ? 308.120 210.152 96.744  1.00 35.37 ? 65  VAL A HA     1 
ATOM   800  H  HB     . VAL A 1 65  ? 307.680 208.539 99.011  1.00 32.84 ? 65  VAL A HB     1 
ATOM   801  H  HG11   . VAL A 1 65  ? 307.761 207.713 96.614  1.00 32.62 ? 65  VAL A HG11   1 
ATOM   802  H  HG12   . VAL A 1 65  ? 308.170 206.810 97.846  1.00 33.33 ? 65  VAL A HG12   1 
ATOM   803  H  HG13   . VAL A 1 65  ? 309.278 207.571 97.010  1.00 32.48 ? 65  VAL A HG13   1 
ATOM   804  H  HG21   . VAL A 1 65  ? 310.300 208.885 98.233  1.00 32.48 ? 65  VAL A HG21   1 
ATOM   805  H  HG22   . VAL A 1 65  ? 309.719 208.731 99.698  1.00 33.19 ? 65  VAL A HG22   1 
ATOM   806  H  HG23   . VAL A 1 65  ? 309.655 210.123 98.963  1.00 33.04 ? 65  VAL A HG23   1 
ATOM   807  N  N      . TRP A 1 66  ? 305.992 209.342 95.870  1.00 35.24 ? 66  TRP A N      1 
ATOM   808  C  CA     . TRP A 1 66  ? 304.714 208.940 95.303  1.00 33.28 ? 66  TRP A CA     1 
ATOM   809  C  C      . TRP A 1 66  ? 304.824 207.495 94.841  1.00 33.22 ? 66  TRP A C      1 
ATOM   810  O  O      . TRP A 1 66  ? 305.440 207.221 93.808  1.00 40.28 ? 66  TRP A O      1 
ATOM   811  C  CB     . TRP A 1 66  ? 304.332 209.825 94.118  1.00 30.89 ? 66  TRP A CB     1 
ATOM   812  C  CG     . TRP A 1 66  ? 304.155 211.260 94.424  1.00 35.49 ? 66  TRP A CG     1 
ATOM   813  C  CD1    . TRP A 1 66  ? 305.128 212.166 94.682  1.00 40.26 ? 66  TRP A CD1    1 
ATOM   814  C  CD2    . TRP A 1 66  ? 302.918 211.968 94.484  1.00 37.19 ? 66  TRP A CD2    1 
ATOM   815  N  NE1    . TRP A 1 66  ? 304.578 213.402 94.909  1.00 41.35 ? 66  TRP A NE1    1 
ATOM   816  C  CE2    . TRP A 1 66  ? 303.218 213.303 94.794  1.00 39.46 ? 66  TRP A CE2    1 
ATOM   817  C  CE3    . TRP A 1 66  ? 301.585 211.600 94.311  1.00 38.34 ? 66  TRP A CE3    1 
ATOM   818  C  CZ2    . TRP A 1 66  ? 302.237 214.269 94.934  1.00 42.82 ? 66  TRP A CZ2    1 
ATOM   819  C  CZ3    . TRP A 1 66  ? 300.615 212.559 94.451  1.00 39.81 ? 66  TRP A CZ3    1 
ATOM   820  C  CH2    . TRP A 1 66  ? 300.943 213.878 94.759  1.00 43.38 ? 66  TRP A CH2    1 
ATOM   821  H  H      . TRP A 1 66  ? 306.617 209.337 95.290  1.00 35.16 ? 66  TRP A H      1 
ATOM   822  H  HA     . TRP A 1 66  ? 304.024 208.998 95.973  1.00 35.58 ? 66  TRP A HA     1 
ATOM   823  H  HB2    . TRP A 1 66  ? 305.027 209.756 93.453  1.00 32.78 ? 66  TRP A HB2    1 
ATOM   824  H  HB3    . TRP A 1 66  ? 303.495 209.506 93.757  1.00 33.99 ? 66  TRP A HB3    1 
ATOM   825  H  HD1    . TRP A 1 66  ? 306.036 211.973 94.700  1.00 38.49 ? 66  TRP A HD1    1 
ATOM   826  H  HE1    . TRP A 1 66  ? 305.010 214.121 95.093  1.00 40.75 ? 66  TRP A HE1    1 
ATOM   827  H  HE3    . TRP A 1 66  ? 301.361 210.725 94.107  1.00 38.37 ? 66  TRP A HE3    1 
ATOM   828  H  HZ2    . TRP A 1 66  ? 302.453 215.148 95.138  1.00 42.11 ? 66  TRP A HZ2    1 
ATOM   829  H  HZ3    . TRP A 1 66  ? 299.725 212.323 94.338  1.00 39.49 ? 66  TRP A HZ3    1 
ATOM   830  H  HH2    . TRP A 1 66  ? 300.264 214.504 94.848  1.00 41.70 ? 66  TRP A HH2    1 
ATOM   831  N  N      . ASP A 1 67  ? 304.223 206.583 95.594  1.00 32.08 ? 67  ASP A N      1 
ATOM   832  C  CA     . ASP A 1 67  ? 304.137 205.179 95.224  1.00 34.66 ? 67  ASP A CA     1 
ATOM   833  C  C      . ASP A 1 67  ? 302.850 204.958 94.446  1.00 35.08 ? 67  ASP A C      1 
ATOM   834  O  O      . ASP A 1 67  ? 301.795 205.476 94.820  1.00 39.27 ? 67  ASP A O      1 
ATOM   835  C  CB     . ASP A 1 67  ? 304.189 204.284 96.464  1.00 36.46 ? 67  ASP A CB     1 
ATOM   836  C  CG     . ASP A 1 67  ? 303.360 203.032 96.318  1.00 43.42 ? 67  ASP A CG     1 
ATOM   837  O  OD1    . ASP A 1 67  ? 303.573 202.287 95.340  1.00 44.91 ? 67  ASP A OD1    1 
ATOM   838  O  OD2    . ASP A 1 67  ? 302.502 202.786 97.192  1.00 43.20 ? 67  ASP A OD2    1 
ATOM   839  H  H      . ASP A 1 67  ? 303.847 206.755 96.339  1.00 35.05 ? 67  ASP A H      1 
ATOM   840  H  HA     . ASP A 1 67  ? 304.879 204.950 94.649  1.00 35.00 ? 67  ASP A HA     1 
ATOM   841  H  HB2    . ASP A 1 67  ? 305.103 204.007 96.617  1.00 35.51 ? 67  ASP A HB2    1 
ATOM   842  H  HB3    . ASP A 1 67  ? 303.861 204.778 97.224  1.00 37.33 ? 67  ASP A HB3    1 
ATOM   843  N  N      . VAL A 1 68  ? 302.947 204.200 93.358  1.00 33.50 ? 68  VAL A N      1 
ATOM   844  C  CA     . VAL A 1 68  ? 301.866 204.020 92.404  1.00 35.49 ? 68  VAL A CA     1 
ATOM   845  C  C      . VAL A 1 68  ? 301.701 202.536 92.117  1.00 38.27 ? 68  VAL A C      1 
ATOM   846  O  O      . VAL A 1 68  ? 302.503 201.703 92.535  1.00 39.43 ? 68  VAL A O      1 
ATOM   847  C  CB     . VAL A 1 68  ? 302.116 204.790 91.097  1.00 33.39 ? 68  VAL A CB     1 
ATOM   848  C  CG1    . VAL A 1 68  ? 302.174 206.250 91.356  1.00 33.64 ? 68  VAL A CG1    1 
ATOM   849  C  CG2    . VAL A 1 68  ? 303.389 204.334 90.474  1.00 32.68 ? 68  VAL A CG2    1 
ATOM   850  H  H      . VAL A 1 68  ? 303.656 203.766 93.139  1.00 34.61 ? 68  VAL A H      1 
ATOM   851  H  HA     . VAL A 1 68  ? 301.044 204.346 92.789  1.00 36.57 ? 68  VAL A HA     1 
ATOM   852  H  HB     . VAL A 1 68  ? 301.393 204.623 90.480  1.00 34.60 ? 68  VAL A HB     1 
ATOM   853  H  HG11   . VAL A 1 68  ? 303.066 206.562 91.149  1.00 33.13 ? 68  VAL A HG11   1 
ATOM   854  H  HG12   . VAL A 1 68  ? 301.971 206.403 92.289  1.00 34.68 ? 68  VAL A HG12   1 
ATOM   855  H  HG13   . VAL A 1 68  ? 301.528 206.692 90.790  1.00 34.17 ? 68  VAL A HG13   1 
ATOM   856  H  HG21   . VAL A 1 68  ? 304.092 204.389 91.134  1.00 33.31 ? 68  VAL A HG21   1 
ATOM   857  H  HG22   . VAL A 1 68  ? 303.585 204.911 89.724  1.00 32.28 ? 68  VAL A HG22   1 
ATOM   858  H  HG23   . VAL A 1 68  ? 303.280 203.419 90.183  1.00 32.63 ? 68  VAL A HG23   1 
ATOM   859  N  N      . GLY A 1 69  ? 300.642 202.216 91.381  1.00 36.42 ? 69  GLY A N      1 
ATOM   860  C  CA     . GLY A 1 69  ? 300.363 200.840 91.056  1.00 34.18 ? 69  GLY A CA     1 
ATOM   861  C  C      . GLY A 1 69  ? 301.210 200.320 89.915  1.00 34.01 ? 69  GLY A C      1 
ATOM   862  O  O      . GLY A 1 69  ? 301.698 201.067 89.071  1.00 38.80 ? 69  GLY A O      1 
ATOM   863  H  H      . GLY A 1 69  ? 300.075 202.775 91.069  1.00 36.27 ? 69  GLY A H      1 
ATOM   864  H  HA2    . GLY A 1 69  ? 300.541 200.290 91.827  1.00 35.46 ? 69  GLY A HA2    1 
ATOM   865  H  HA3    . GLY A 1 69  ? 299.435 200.748 90.817  1.00 35.84 ? 69  GLY A HA3    1 
ATOM   866  N  N      . GLY A 1 70  ? 301.373 199.005 89.899  1.00 31.76 ? 70  GLY A N      1 
ATOM   867  C  CA     . GLY A 1 70  ? 302.147 198.348 88.873  1.00 31.71 ? 70  GLY A CA     1 
ATOM   868  C  C      . GLY A 1 70  ? 301.325 197.410 88.024  1.00 34.14 ? 70  GLY A C      1 
ATOM   869  O  O      . GLY A 1 70  ? 301.823 196.876 87.030  1.00 38.01 ? 70  GLY A O      1 
ATOM   870  H  H      . GLY A 1 70  ? 301.052 198.475 90.485  1.00 33.46 ? 70  GLY A H      1 
ATOM   871  H  HA2    . GLY A 1 70  ? 302.543 199.011 88.296  1.00 33.52 ? 70  GLY A HA2    1 
ATOM   872  H  HA3    . GLY A 1 70  ? 302.851 197.837 89.288  1.00 32.65 ? 70  GLY A HA3    1 
ATOM   873  N  N      . GLN A 1 71  ? 300.067 197.194 88.401  1.00 35.55 ? 71  GLN A N      1 
ATOM   874  C  CA     . GLN A 1 71  ? 299.176 196.400 87.572  1.00 39.33 ? 71  GLN A CA     1 
ATOM   875  C  C      . GLN A 1 71  ? 299.150 196.966 86.163  1.00 43.02 ? 71  GLN A C      1 
ATOM   876  O  O      . GLN A 1 71  ? 299.347 198.165 85.947  1.00 43.24 ? 71  GLN A O      1 
ATOM   877  C  CB     . GLN A 1 71  ? 297.762 196.389 88.151  1.00 38.84 ? 71  GLN A CB     1 
ATOM   878  C  CG     . GLN A 1 71  ? 297.640 195.835 89.544  1.00 40.57 ? 71  GLN A CG     1 
ATOM   879  C  CD     . GLN A 1 71  ? 296.204 195.796 90.019  1.00 46.29 ? 71  GLN A CD     1 
ATOM   880  O  OE1    . GLN A 1 71  ? 295.300 196.304 89.356  1.00 46.36 ? 71  GLN A OE1    1 
ATOM   881  N  NE2    . GLN A 1 71  ? 295.984 195.184 91.174  1.00 46.17 ? 71  GLN A NE2    1 
ATOM   882  H  H      . GLN A 1 71  ? 299.713 197.483 89.125  1.00 36.83 ? 71  GLN A H      1 
ATOM   883  H  HA     . GLN A 1 71  ? 299.495 195.493 87.529  1.00 39.14 ? 71  GLN A HA     1 
ATOM   884  H  HB2    . GLN A 1 71  ? 297.439 197.295 88.179  1.00 39.94 ? 71  GLN A HB2    1 
ATOM   885  H  HB3    . GLN A 1 71  ? 297.190 195.860 87.579  1.00 39.48 ? 71  GLN A HB3    1 
ATOM   886  H  HG2    . GLN A 1 71  ? 297.987 194.933 89.558  1.00 40.79 ? 71  GLN A HG2    1 
ATOM   887  H  HG3    . GLN A 1 71  ? 298.138 196.400 90.152  1.00 40.40 ? 71  GLN A HG3    1 
ATOM   888  H  HE21   . GLN A 1 71  ? 296.643 194.840 91.605  1.00 44.74 ? 71  GLN A HE21   1 
ATOM   889  H  HE22   . GLN A 1 71  ? 295.187 195.131 91.493  1.00 43.33 ? 71  GLN A HE22   1 
ATOM   890  N  N      . ASP A 1 72  ? 298.918 196.086 85.191  1.00 40.22 ? 72  ASP A N      1 
ATOM   891  C  CA     . ASP A 1 72  ? 298.973 196.500 83.796  1.00 39.24 ? 72  ASP A CA     1 
ATOM   892  C  C      . ASP A 1 72  ? 298.018 197.648 83.512  1.00 40.17 ? 72  ASP A C      1 
ATOM   893  O  O      . ASP A 1 72  ? 298.267 198.454 82.611  1.00 40.69 ? 72  ASP A O      1 
ATOM   894  C  CB     . ASP A 1 72  ? 298.656 195.313 82.893  1.00 43.91 ? 72  ASP A CB     1 
ATOM   895  C  CG     . ASP A 1 72  ? 299.479 195.311 81.624  1.00 53.15 ? 72  ASP A CG     1 
ATOM   896  O  OD1    . ASP A 1 72  ? 299.739 196.404 81.081  1.00 52.46 ? 72  ASP A OD1    1 
ATOM   897  O  OD2    . ASP A 1 72  ? 299.860 194.213 81.164  1.00 56.15 ? 72  ASP A OD2    1 
ATOM   898  H  H      . ASP A 1 72  ? 298.728 195.258 85.314  1.00 40.52 ? 72  ASP A H      1 
ATOM   899  H  HA     . ASP A 1 72  ? 299.870 196.796 83.593  1.00 41.69 ? 72  ASP A HA     1 
ATOM   900  H  HB2    . ASP A 1 72  ? 298.855 194.498 83.373  1.00 44.03 ? 72  ASP A HB2    1 
ATOM   901  H  HB3    . ASP A 1 72  ? 297.720 195.344 82.655  1.00 44.95 ? 72  ASP A HB3    1 
ATOM   902  N  N      . ARG A 1 73  ? 296.918 197.734 84.257  1.00 40.80 ? 73  ARG A N      1 
ATOM   903  C  CA     . ARG A 1 73  ? 295.922 198.766 84.018  1.00 37.91 ? 73  ARG A CA     1 
ATOM   904  C  C      . ARG A 1 73  ? 296.320 200.125 84.570  1.00 38.10 ? 73  ARG A C      1 
ATOM   905  O  O      . ARG A 1 73  ? 295.811 201.143 84.092  1.00 37.68 ? 73  ARG A O      1 
ATOM   906  C  CB     . ARG A 1 73  ? 294.594 198.341 84.626  1.00 36.49 ? 73  ARG A CB     1 
ATOM   907  C  CG     . ARG A 1 73  ? 293.978 197.148 83.951  1.00 37.04 ? 73  ARG A CG     1 
ATOM   908  C  CD     . ARG A 1 73  ? 292.959 197.570 82.931  1.00 37.11 ? 73  ARG A CD     1 
ATOM   909  N  NE     . ARG A 1 73  ? 293.444 198.659 82.097  1.00 37.08 ? 73  ARG A NE     1 
ATOM   910  C  CZ     . ARG A 1 73  ? 294.199 198.502 81.020  1.00 36.94 ? 73  ARG A CZ     1 
ATOM   911  N  NH1    . ARG A 1 73  ? 294.597 197.308 80.622  1.00 40.46 ? 73  ARG A NH1    1 
ATOM   912  N  NH2    . ARG A 1 73  ? 294.573 199.573 80.330  1.00 34.35 ? 73  ARG A NH2    1 
ATOM   913  H  H      . ARG A 1 73  ? 296.720 197.201 84.896  1.00 40.53 ? 73  ARG A H      1 
ATOM   914  H  HA     . ARG A 1 73  ? 295.801 198.864 83.069  1.00 38.45 ? 73  ARG A HA     1 
ATOM   915  H  HB2    . ARG A 1 73  ? 294.732 198.119 85.557  1.00 38.17 ? 73  ARG A HB2    1 
ATOM   916  H  HB3    . ARG A 1 73  ? 293.972 199.075 84.547  1.00 36.61 ? 73  ARG A HB3    1 
ATOM   917  H  HG2    . ARG A 1 73  ? 294.671 196.649 83.498  1.00 38.22 ? 73  ARG A HG2    1 
ATOM   918  H  HG3    . ARG A 1 73  ? 293.536 196.596 84.613  1.00 36.85 ? 73  ARG A HG3    1 
ATOM   919  H  HD2    . ARG A 1 73  ? 292.744 196.819 82.362  1.00 36.69 ? 73  ARG A HD2    1 
ATOM   920  H  HD3    . ARG A 1 73  ? 292.170 197.877 83.396  1.00 37.99 ? 73  ARG A HD3    1 
ATOM   921  H  HE     . ARG A 1 73  ? 293.406 199.447 82.431  1.00 37.37 ? 73  ARG A HE     1 
ATOM   922  H  HH11   . ARG A 1 73  ? 294.366 196.608 81.061  1.00 39.59 ? 73  ARG A HH11   1 
ATOM   923  H  HH12   . ARG A 1 73  ? 295.088 197.236 79.920  1.00 39.54 ? 73  ARG A HH12   1 
ATOM   924  H  HH21   . ARG A 1 73  ? 294.323 200.355 80.579  1.00 35.21 ? 73  ARG A HH21   1 
ATOM   925  H  HH22   . ARG A 1 73  ? 295.065 199.481 79.633  1.00 35.50 ? 73  ARG A HH22   1 
ATOM   926  N  N      . ILE A 1 74  ? 297.211 200.173 85.557  1.00 40.26 ? 74  ILE A N      1 
ATOM   927  C  CA     . ILE A 1 74  ? 297.657 201.428 86.139  1.00 40.15 ? 74  ILE A CA     1 
ATOM   928  C  C      . ILE A 1 74  ? 298.974 201.897 85.557  1.00 40.10 ? 74  ILE A C      1 
ATOM   929  O  O      . ILE A 1 74  ? 299.291 203.088 85.659  1.00 40.81 ? 74  ILE A O      1 
ATOM   930  C  CB     . ILE A 1 74  ? 297.756 201.333 87.671  1.00 37.19 ? 74  ILE A CB     1 
ATOM   931  C  CG1    . ILE A 1 74  ? 296.394 201.015 88.273  1.00 33.60 ? 74  ILE A CG1    1 
ATOM   932  C  CG2    . ILE A 1 74  ? 298.285 202.624 88.242  1.00 39.08 ? 74  ILE A CG2    1 
ATOM   933  C  CD1    . ILE A 1 74  ? 296.164 199.589 88.464  1.00 36.48 ? 74  ILE A CD1    1 
ATOM   934  H  H      . ILE A 1 74  ? 297.580 199.483 85.907  1.00 39.56 ? 74  ILE A H      1 
ATOM   935  H  HA     . ILE A 1 74  ? 297.006 202.110 85.940  1.00 39.31 ? 74  ILE A HA     1 
ATOM   936  H  HB     . ILE A 1 74  ? 298.359 200.618 87.895  1.00 37.26 ? 74  ILE A HB     1 
ATOM   937  H  HG12   . ILE A 1 74  ? 296.318 201.431 89.139  1.00 34.73 ? 74  ILE A HG12   1 
ATOM   938  H  HG13   . ILE A 1 74  ? 295.708 201.343 87.681  1.00 34.76 ? 74  ILE A HG13   1 
ATOM   939  H  HG21   . ILE A 1 74  ? 299.237 202.673 88.080  1.00 38.49 ? 74  ILE A HG21   1 
ATOM   940  H  HG22   . ILE A 1 74  ? 298.106 202.647 89.193  1.00 37.78 ? 74  ILE A HG22   1 
ATOM   941  H  HG23   . ILE A 1 74  ? 297.840 203.360 87.800  1.00 38.81 ? 74  ILE A HG23   1 
ATOM   942  H  HD11   . ILE A 1 74  ? 296.324 199.141 87.626  1.00 38.38 ? 74  ILE A HD11   1 
ATOM   943  H  HD12   . ILE A 1 74  ? 295.251 199.450 88.751  1.00 37.07 ? 74  ILE A HD12   1 
ATOM   944  H  HD13   . ILE A 1 74  ? 296.782 199.269 89.137  1.00 37.29 ? 74  ILE A HD13   1 
ATOM   945  N  N      . ARG A 1 75  ? 299.748 201.011 84.935  1.00 37.41 ? 75  ARG A N      1 
ATOM   946  C  CA     . ARG A 1 75  ? 300.985 201.419 84.288  1.00 35.88 ? 75  ARG A CA     1 
ATOM   947  C  C      . ARG A 1 75  ? 300.767 202.475 83.217  1.00 39.94 ? 75  ARG A C      1 
ATOM   948  O  O      . ARG A 1 75  ? 301.731 203.133 82.814  1.00 42.47 ? 75  ARG A O      1 
ATOM   949  C  CB     . ARG A 1 75  ? 301.686 200.216 83.663  1.00 36.21 ? 75  ARG A CB     1 
ATOM   950  C  CG     . ARG A 1 75  ? 302.466 199.372 84.625  1.00 36.88 ? 75  ARG A CG     1 
ATOM   951  C  CD     . ARG A 1 75  ? 303.121 198.222 83.924  1.00 35.83 ? 75  ARG A CD     1 
ATOM   952  N  NE     . ARG A 1 75  ? 302.977 196.987 84.675  1.00 35.80 ? 75  ARG A NE     1 
ATOM   953  C  CZ     . ARG A 1 75  ? 303.138 195.780 84.158  1.00 40.40 ? 75  ARG A CZ     1 
ATOM   954  N  NH1    . ARG A 1 75  ? 303.461 195.613 82.889  1.00 40.29 ? 75  ARG A NH1    1 
ATOM   955  N  NH2    . ARG A 1 75  ? 302.962 194.714 84.931  1.00 39.57 ? 75  ARG A NH2    1 
ATOM   956  H  H      . ARG A 1 75  ? 299.580 200.172 84.883  1.00 38.43 ? 75  ARG A H      1 
ATOM   957  H  HA     . ARG A 1 75  ? 301.575 201.791 84.953  1.00 37.31 ? 75  ARG A HA     1 
ATOM   958  H  HB2    . ARG A 1 75  ? 301.017 199.648 83.260  1.00 38.41 ? 75  ARG A HB2    1 
ATOM   959  H  HB3    . ARG A 1 75  ? 302.301 200.531 82.990  1.00 37.01 ? 75  ARG A HB3    1 
ATOM   960  H  HG2    . ARG A 1 75  ? 303.159 199.907 85.029  1.00 37.21 ? 75  ARG A HG2    1 
ATOM   961  H  HG3    . ARG A 1 75  ? 301.872 199.015 85.297  1.00 37.85 ? 75  ARG A HG3    1 
ATOM   962  H  HD2    . ARG A 1 75  ? 302.716 198.104 83.053  1.00 37.89 ? 75  ARG A HD2    1 
ATOM   963  H  HD3    . ARG A 1 75  ? 304.064 198.403 83.830  1.00 36.54 ? 75  ARG A HD3    1 
ATOM   964  H  HE     . ARG A 1 75  ? 302.948 197.048 85.529  1.00 36.91 ? 75  ARG A HE     1 
ATOM   965  H  HH11   . ARG A 1 75  ? 303.575 196.298 82.384  1.00 39.58 ? 75  ARG A HH11   1 
ATOM   966  H  HH12   . ARG A 1 75  ? 303.557 194.822 82.573  1.00 40.53 ? 75  ARG A HH12   1 
ATOM   967  H  HH21   . ARG A 1 75  ? 302.751 194.813 85.757  1.00 38.60 ? 75  ARG A HH21   1 
ATOM   968  H  HH22   . ARG A 1 75  ? 303.061 193.927 84.605  1.00 40.50 ? 75  ARG A HH22   1 
ATOM   969  N  N      . SER A 1 76  ? 299.537 202.641 82.744  1.00 41.03 ? 76  SER A N      1 
ATOM   970  C  CA     . SER A 1 76  ? 299.215 203.659 81.758  1.00 40.88 ? 76  SER A CA     1 
ATOM   971  C  C      . SER A 1 76  ? 298.804 204.983 82.379  1.00 43.68 ? 76  SER A C      1 
ATOM   972  O  O      . SER A 1 76  ? 298.552 205.941 81.643  1.00 48.00 ? 76  SER A O      1 
ATOM   973  C  CB     . SER A 1 76  ? 298.091 203.166 80.847  1.00 42.36 ? 76  SER A CB     1 
ATOM   974  O  OG     . SER A 1 76  ? 296.922 202.870 81.585  1.00 43.34 ? 76  SER A OG     1 
ATOM   975  H  H      . SER A 1 76  ? 298.860 202.174 82.988  1.00 40.36 ? 76  SER A H      1 
ATOM   976  H  HA     . SER A 1 76  ? 299.995 203.818 81.210  1.00 40.67 ? 76  SER A HA     1 
ATOM   977  H  HB2    . SER A 1 76  ? 297.894 203.853 80.195  1.00 42.80 ? 76  SER A HB2    1 
ATOM   978  H  HB3    . SER A 1 76  ? 298.387 202.359 80.404  1.00 41.18 ? 76  SER A HB3    1 
ATOM   979  H  HG     . SER A 1 76  ? 296.910 203.311 82.296  1.00 42.18 ? 76  SER A HG     1 
ATOM   980  N  N      . LEU A 1 77  ? 298.726 205.055 83.703  1.00 41.57 ? 77  LEU A N      1 
ATOM   981  C  CA     . LEU A 1 77  ? 298.382 206.276 84.409  1.00 40.98 ? 77  LEU A CA     1 
ATOM   982  C  C      . LEU A 1 77  ? 299.582 206.913 85.085  1.00 42.05 ? 77  LEU A C      1 
ATOM   983  O  O      . LEU A 1 77  ? 299.427 207.924 85.771  1.00 41.30 ? 77  LEU A O      1 
ATOM   984  C  CB     . LEU A 1 77  ? 297.305 205.995 85.450  1.00 38.07 ? 77  LEU A CB     1 
ATOM   985  C  CG     . LEU A 1 77  ? 295.942 205.565 84.939  1.00 38.46 ? 77  LEU A CG     1 
ATOM   986  C  CD1    . LEU A 1 77  ? 295.216 204.844 86.028  1.00 39.45 ? 77  LEU A CD1    1 
ATOM   987  C  CD2    . LEU A 1 77  ? 295.162 206.763 84.514  1.00 39.40 ? 77  LEU A CD2    1 
ATOM   988  H  H      . LEU A 1 77  ? 298.876 204.394 84.228  1.00 41.15 ? 77  LEU A H      1 
ATOM   989  H  HA     . LEU A 1 77  ? 298.026 206.912 83.777  1.00 41.24 ? 77  LEU A HA     1 
ATOM   990  H  HB2    . LEU A 1 77  ? 297.620 205.292 86.032  1.00 38.81 ? 77  LEU A HB2    1 
ATOM   991  H  HB3    . LEU A 1 77  ? 297.166 206.802 85.964  1.00 39.37 ? 77  LEU A HB3    1 
ATOM   992  H  HG     . LEU A 1 77  ? 296.047 204.975 84.180  1.00 39.82 ? 77  LEU A HG     1 
ATOM   993  H  HD11   . LEU A 1 77  ? 295.732 204.065 86.284  1.00 39.15 ? 77  LEU A HD11   1 
ATOM   994  H  HD12   . LEU A 1 77  ? 294.344 204.576 85.702  1.00 39.60 ? 77  LEU A HD12   1 
ATOM   995  H  HD13   . LEU A 1 77  ? 295.126 205.446 86.782  1.00 39.40 ? 77  LEU A HD13   1 
ATOM   996  H  HD21   . LEU A 1 77  ? 295.053 207.337 85.283  1.00 37.99 ? 77  LEU A HD21   1 
ATOM   997  H  HD22   . LEU A 1 77  ? 294.297 206.474 84.192  1.00 40.30 ? 77  LEU A HD22   1 
ATOM   998  H  HD23   . LEU A 1 77  ? 295.650 207.222 83.816  1.00 39.52 ? 77  LEU A HD23   1 
ATOM   999  N  N      . TRP A 1 78  ? 300.768 206.330 84.933  1.00 41.44 ? 78  TRP A N      1 
ATOM   1000 C  CA     . TRP A 1 78  ? 301.953 206.912 85.541  1.00 39.08 ? 78  TRP A CA     1 
ATOM   1001 C  C      . TRP A 1 78  ? 302.290 208.266 84.942  1.00 45.12 ? 78  TRP A C      1 
ATOM   1002 O  O      . TRP A 1 78  ? 302.918 209.085 85.617  1.00 44.83 ? 78  TRP A O      1 
ATOM   1003 C  CB     . TRP A 1 78  ? 303.148 205.978 85.376  1.00 35.46 ? 78  TRP A CB     1 
ATOM   1004 C  CG     . TRP A 1 78  ? 303.072 204.707 86.145  1.00 33.43 ? 78  TRP A CG     1 
ATOM   1005 C  CD1    . TRP A 1 78  ? 302.121 204.346 87.041  1.00 35.49 ? 78  TRP A CD1    1 
ATOM   1006 C  CD2    . TRP A 1 78  ? 303.995 203.620 86.081  1.00 31.83 ? 78  TRP A CD2    1 
ATOM   1007 N  NE1    . TRP A 1 78  ? 302.393 203.103 87.544  1.00 33.61 ? 78  TRP A NE1    1 
ATOM   1008 C  CE2    . TRP A 1 78  ? 303.541 202.636 86.968  1.00 33.91 ? 78  TRP A CE2    1 
ATOM   1009 C  CE3    . TRP A 1 78  ? 305.161 203.385 85.358  1.00 30.24 ? 78  TRP A CE3    1 
ATOM   1010 C  CZ2    . TRP A 1 78  ? 304.211 201.438 87.151  1.00 31.21 ? 78  TRP A CZ2    1 
ATOM   1011 C  CZ3    . TRP A 1 78  ? 305.822 202.198 85.542  1.00 27.32 ? 78  TRP A CZ3    1 
ATOM   1012 C  CH2    . TRP A 1 78  ? 305.347 201.240 86.429  1.00 28.01 ? 78  TRP A CH2    1 
ATOM   1013 H  H      . TRP A 1 78  ? 300.911 205.612 84.490  1.00 39.89 ? 78  TRP A H      1 
ATOM   1014 H  HA     . TRP A 1 78  ? 301.792 207.045 86.484  1.00 38.71 ? 78  TRP A HA     1 
ATOM   1015 H  HB2    . TRP A 1 78  ? 303.222 205.744 84.444  1.00 36.88 ? 78  TRP A HB2    1 
ATOM   1016 H  HB3    . TRP A 1 78  ? 303.941 206.447 85.660  1.00 35.74 ? 78  TRP A HB3    1 
ATOM   1017 H  HD1    . TRP A 1 78  ? 301.396 204.867 87.279  1.00 36.89 ? 78  TRP A HD1    1 
ATOM   1018 H  HE1    . TRP A 1 78  ? 301.925 202.683 88.125  1.00 34.69 ? 78  TRP A HE1    1 
ATOM   1019 H  HE3    . TRP A 1 78  ? 305.481 204.019 84.765  1.00 30.80 ? 78  TRP A HE3    1 
ATOM   1020 H  HZ2    . TRP A 1 78  ? 303.896 200.798 87.742  1.00 32.27 ? 78  TRP A HZ2    1 
ATOM   1021 H  HZ3    . TRP A 1 78  ? 306.599 202.030 85.070  1.00 27.74 ? 78  TRP A HZ3    1 
ATOM   1022 H  HH2    . TRP A 1 78  ? 305.816 200.450 86.530  1.00 29.96 ? 78  TRP A HH2    1 
ATOM   1023 N  N      . ARG A 1 79  ? 301.865 208.522 83.705  1.00 48.60 ? 79  ARG A N      1 
ATOM   1024 C  CA     . ARG A 1 79  ? 302.230 209.757 83.023  1.00 44.59 ? 79  ARG A CA     1 
ATOM   1025 C  C      . ARG A 1 79  ? 301.743 210.987 83.776  1.00 46.43 ? 79  ARG A C      1 
ATOM   1026 O  O      . ARG A 1 79  ? 302.368 212.050 83.694  1.00 49.75 ? 79  ARG A O      1 
ATOM   1027 C  CB     . ARG A 1 79  ? 301.661 209.748 81.609  1.00 48.33 ? 79  ARG A CB     1 
ATOM   1028 C  CG     . ARG A 1 79  ? 302.222 208.678 80.686  1.00 54.10 ? 79  ARG A CG     1 
ATOM   1029 C  CD     . ARG A 1 79  ? 301.190 208.243 79.626  1.00 59.74 ? 79  ARG A CD     1 
ATOM   1030 N  NE     . ARG A 1 79  ? 301.782 207.569 78.471  1.00 64.05 ? 79  ARG A NE     1 
ATOM   1031 C  CZ     . ARG A 1 79  ? 302.656 208.122 77.642  1.00 61.41 ? 79  ARG A CZ     1 
ATOM   1032 N  NH1    . ARG A 1 79  ? 303.073 209.366 77.807  1.00 56.34 ? 79  ARG A NH1    1 
ATOM   1033 N  NH2    . ARG A 1 79  ? 303.115 207.412 76.614  1.00 63.92 ? 79  ARG A NH2    1 
ATOM   1034 H  H      . ARG A 1 79  ? 301.361 208.002 83.251  1.00 46.51 ? 79  ARG A H      1 
ATOM   1035 H  HA     . ARG A 1 79  ? 303.191 209.815 82.958  1.00 44.80 ? 79  ARG A HA     1 
ATOM   1036 H  HB2    . ARG A 1 79  ? 300.704 209.629 81.664  1.00 48.65 ? 79  ARG A HB2    1 
ATOM   1037 H  HB3    . ARG A 1 79  ? 301.876 210.597 81.200  1.00 50.06 ? 79  ARG A HB3    1 
ATOM   1038 H  HG2    . ARG A 1 79  ? 302.994 209.043 80.232  1.00 54.69 ? 79  ARG A HG2    1 
ATOM   1039 H  HG3    . ARG A 1 79  ? 302.474 207.904 81.215  1.00 51.86 ? 79  ARG A HG3    1 
ATOM   1040 H  HD2    . ARG A 1 79  ? 300.575 207.619 80.037  1.00 55.61 ? 79  ARG A HD2    1 
ATOM   1041 H  HD3    . ARG A 1 79  ? 300.700 209.021 79.311  1.00 57.84 ? 79  ARG A HD3    1 
ATOM   1042 H  HE     . ARG A 1 79  ? 301.686 206.715 78.418  1.00 61.86 ? 79  ARG A HE     1 
ATOM   1043 H  HH11   . ARG A 1 79  ? 302.772 209.806 78.477  1.00 56.63 ? 79  ARG A HH11   1 
ATOM   1044 H  HH12   . ARG A 1 79  ? 303.639 209.733 77.270  1.00 57.64 ? 79  ARG A HH12   1 
ATOM   1045 H  HH21   . ARG A 1 79  ? 302.845 206.603 76.500  1.00 63.19 ? 79  ARG A HH21   1 
ATOM   1046 H  HH22   . ARG A 1 79  ? 303.679 207.758 76.067  1.00 63.26 ? 79  ARG A HH22   1 
ATOM   1047 N  N      . HIS A 1 80  ? 300.631 210.872 84.505  1.00 43.75 ? 80  HIS A N      1 
ATOM   1048 C  CA     . HIS A 1 80  ? 300.127 212.006 85.268  1.00 44.91 ? 80  HIS A CA     1 
ATOM   1049 C  C      . HIS A 1 80  ? 301.126 212.498 86.302  1.00 43.39 ? 80  HIS A C      1 
ATOM   1050 O  O      . HIS A 1 80  ? 300.998 213.629 86.784  1.00 45.52 ? 80  HIS A O      1 
ATOM   1051 C  CB     . HIS A 1 80  ? 298.817 211.628 85.961  1.00 43.08 ? 80  HIS A CB     1 
ATOM   1052 C  CG     . HIS A 1 80  ? 297.762 211.126 85.027  1.00 55.16 ? 80  HIS A CG     1 
ATOM   1053 N  ND1    . HIS A 1 80  ? 297.855 211.256 83.659  1.00 58.93 ? 80  HIS A ND1    1 
ATOM   1054 C  CD2    . HIS A 1 80  ? 296.586 210.498 85.264  1.00 57.56 ? 80  HIS A CD2    1 
ATOM   1055 C  CE1    . HIS A 1 80  ? 296.786 210.724 83.094  1.00 54.22 ? 80  HIS A CE1    1 
ATOM   1056 N  NE2    . HIS A 1 80  ? 295.999 210.259 84.046  1.00 50.63 ? 80  HIS A NE2    1 
ATOM   1057 H  H      . HIS A 1 80  ? 300.157 210.164 84.575  1.00 45.61 ? 80  HIS A H      1 
ATOM   1058 H  HA     . HIS A 1 80  ? 299.945 212.729 84.657  1.00 47.56 ? 80  HIS A HA     1 
ATOM   1059 H  HB2    . HIS A 1 80  ? 298.992 210.941 86.616  1.00 44.99 ? 80  HIS A HB2    1 
ATOM   1060 H  HB3    . HIS A 1 80  ? 298.462 212.415 86.400  1.00 45.58 ? 80  HIS A HB3    1 
ATOM   1061 H  HD1    . HIS A 1 80  ? 298.509 211.620 83.240  1.00 53.04 ? 80  HIS A HD1    1 
ATOM   1062 H  HD2    . HIS A 1 80  ? 296.242 210.270 86.095  1.00 52.71 ? 80  HIS A HD2    1 
ATOM   1063 H  HE1    . HIS A 1 80  ? 296.612 210.684 82.182  1.00 52.61 ? 80  HIS A HE1    1 
ATOM   1064 N  N      . TYR A 1 81  ? 302.105 211.674 86.669  1.00 42.07 ? 81  TYR A N      1 
ATOM   1065 C  CA     . TYR A 1 81  ? 303.038 212.002 87.735  1.00 43.50 ? 81  TYR A CA     1 
ATOM   1066 C  C      . TYR A 1 81  ? 304.439 212.346 87.249  1.00 46.09 ? 81  TYR A C      1 
ATOM   1067 O  O      . TYR A 1 81  ? 305.248 212.827 88.049  1.00 47.35 ? 81  TYR A O      1 
ATOM   1068 C  CB     . TYR A 1 81  ? 303.133 210.833 88.721  1.00 40.46 ? 81  TYR A CB     1 
ATOM   1069 C  CG     . TYR A 1 81  ? 301.806 210.242 89.117  1.00 43.26 ? 81  TYR A CG     1 
ATOM   1070 C  CD1    . TYR A 1 81  ? 301.073 210.760 90.169  1.00 39.17 ? 81  TYR A CD1    1 
ATOM   1071 C  CD2    . TYR A 1 81  ? 301.291 209.156 88.440  1.00 45.38 ? 81  TYR A CD2    1 
ATOM   1072 C  CE1    . TYR A 1 81  ? 299.865 210.216 90.526  1.00 38.59 ? 81  TYR A CE1    1 
ATOM   1073 C  CE2    . TYR A 1 81  ? 300.084 208.608 88.790  1.00 41.79 ? 81  TYR A CE2    1 
ATOM   1074 C  CZ     . TYR A 1 81  ? 299.377 209.141 89.834  1.00 42.68 ? 81  TYR A CZ     1 
ATOM   1075 O  OH     . TYR A 1 81  ? 298.174 208.585 90.177  1.00 47.21 ? 81  TYR A OH     1 
ATOM   1076 H  H      . TYR A 1 81  ? 302.242 210.908 86.313  1.00 43.31 ? 81  TYR A H      1 
ATOM   1077 H  HA     . TYR A 1 81  ? 302.700 212.765 88.222  1.00 44.03 ? 81  TYR A HA     1 
ATOM   1078 H  HB2    . TYR A 1 81  ? 303.647 210.134 88.299  1.00 41.50 ? 81  TYR A HB2    1 
ATOM   1079 H  HB3    . TYR A 1 81  ? 303.574 211.138 89.525  1.00 40.43 ? 81  TYR A HB3    1 
ATOM   1080 H  HD1    . TYR A 1 81  ? 301.401 211.489 90.638  1.00 40.53 ? 81  TYR A HD1    1 
ATOM   1081 H  HD2    . TYR A 1 81  ? 301.770 208.796 87.732  1.00 43.36 ? 81  TYR A HD2    1 
ATOM   1082 H  HE1    . TYR A 1 81  ? 299.379 210.572 91.230  1.00 39.59 ? 81  TYR A HE1    1 
ATOM   1083 H  HE2    . TYR A 1 81  ? 299.747 207.880 88.327  1.00 41.21 ? 81  TYR A HE2    1 
ATOM   1084 H  HH     . TYR A 1 81  ? 297.999 207.966 89.638  1.00 44.55 ? 81  TYR A HH     1 
ATOM   1085 N  N      . TYR A 1 82  ? 304.749 212.121 85.971  1.00 44.94 ? 82  TYR A N      1 
ATOM   1086 C  CA     . TYR A 1 82  ? 306.094 212.395 85.477  1.00 41.24 ? 82  TYR A CA     1 
ATOM   1087 C  C      . TYR A 1 82  ? 306.492 213.849 85.677  1.00 44.41 ? 82  TYR A C      1 
ATOM   1088 O  O      . TYR A 1 82  ? 307.676 214.147 85.869  1.00 46.76 ? 82  TYR A O      1 
ATOM   1089 C  CB     . TYR A 1 82  ? 306.197 212.045 83.996  1.00 42.60 ? 82  TYR A CB     1 
ATOM   1090 C  CG     . TYR A 1 82  ? 306.182 210.577 83.658  1.00 41.83 ? 82  TYR A CG     1 
ATOM   1091 C  CD1    . TYR A 1 82  ? 306.204 209.604 84.640  1.00 42.05 ? 82  TYR A CD1    1 
ATOM   1092 C  CD2    . TYR A 1 82  ? 306.157 210.166 82.344  1.00 44.96 ? 82  TYR A CD2    1 
ATOM   1093 C  CE1    . TYR A 1 82  ? 306.193 208.272 84.316  1.00 40.06 ? 82  TYR A CE1    1 
ATOM   1094 C  CE2    . TYR A 1 82  ? 306.145 208.841 82.014  1.00 45.05 ? 82  TYR A CE2    1 
ATOM   1095 C  CZ     . TYR A 1 82  ? 306.163 207.897 83.000  1.00 41.43 ? 82  TYR A CZ     1 
ATOM   1096 O  OH     . TYR A 1 82  ? 306.152 206.570 82.652  1.00 40.72 ? 82  TYR A OH     1 
ATOM   1097 H  H      . TYR A 1 82  ? 304.209 211.808 85.383  1.00 44.67 ? 82  TYR A H      1 
ATOM   1098 H  HA     . TYR A 1 82  ? 306.727 211.854 85.961  1.00 41.99 ? 82  TYR A HA     1 
ATOM   1099 H  HB2    . TYR A 1 82  ? 305.447 212.453 83.545  1.00 43.55 ? 82  TYR A HB2    1 
ATOM   1100 H  HB3    . TYR A 1 82  ? 307.022 212.404 83.653  1.00 42.45 ? 82  TYR A HB3    1 
ATOM   1101 H  HD1    . TYR A 1 82  ? 306.224 209.855 85.531  1.00 42.68 ? 82  TYR A HD1    1 
ATOM   1102 H  HD2    . TYR A 1 82  ? 306.143 210.805 81.674  1.00 44.75 ? 82  TYR A HD2    1 
ATOM   1103 H  HE1    . TYR A 1 82  ? 306.206 207.630 84.983  1.00 39.84 ? 82  TYR A HE1    1 
ATOM   1104 H  HE2    . TYR A 1 82  ? 306.126 208.580 81.125  1.00 45.23 ? 82  TYR A HE2    1 
ATOM   1105 H  HH     . TYR A 1 82  ? 305.993 206.496 81.830  1.00 40.70 ? 82  TYR A HH     1 
ATOM   1106 N  N      . ARG A 1 83  ? 305.531 214.763 85.627  1.00 49.96 ? 83  ARG A N      1 
ATOM   1107 C  CA     . ARG A 1 83  ? 305.845 216.184 85.640  1.00 55.65 ? 83  ARG A CA     1 
ATOM   1108 C  C      . ARG A 1 83  ? 306.400 216.615 86.989  1.00 55.50 ? 83  ARG A C      1 
ATOM   1109 O  O      . ARG A 1 83  ? 305.917 216.196 88.043  1.00 54.05 ? 83  ARG A O      1 
ATOM   1110 C  CB     . ARG A 1 83  ? 304.600 216.995 85.309  1.00 59.73 ? 83  ARG A CB     1 
ATOM   1111 C  CG     . ARG A 1 83  ? 304.886 218.446 84.991  1.00 62.57 ? 83  ARG A CG     1 
ATOM   1112 C  CD     . ARG A 1 83  ? 303.964 218.977 83.909  1.00 66.69 ? 83  ARG A CD     1 
ATOM   1113 N  NE     . ARG A 1 83  ? 302.579 219.053 84.358  1.00 70.53 ? 83  ARG A NE     1 
ATOM   1114 C  CZ     . ARG A 1 83  ? 302.137 219.877 85.298  1.00 69.91 ? 83  ARG A CZ     1 
ATOM   1115 N  NH1    . ARG A 1 83  ? 302.944 220.730 85.908  1.00 66.45 ? 83  ARG A NH1    1 
ATOM   1116 N  NH2    . ARG A 1 83  ? 300.851 219.846 85.634  1.00 69.95 ? 83  ARG A NH2    1 
ATOM   1117 H  H      . ARG A 1 83  ? 304.694 214.587 85.583  1.00 49.19 ? 83  ARG A H      1 
ATOM   1118 H  HA     . ARG A 1 83  ? 306.516 216.367 84.970  1.00 53.76 ? 83  ARG A HA     1 
ATOM   1119 H  HB2    . ARG A 1 83  ? 304.163 216.596 84.543  1.00 58.35 ? 83  ARG A HB2    1 
ATOM   1120 H  HB3    . ARG A 1 83  ? 304.010 216.969 86.076  1.00 57.63 ? 83  ARG A HB3    1 
ATOM   1121 H  HG2    . ARG A 1 83  ? 304.750 218.972 85.792  1.00 62.64 ? 83  ARG A HG2    1 
ATOM   1122 H  HG3    . ARG A 1 83  ? 305.800 218.532 84.685  1.00 60.16 ? 83  ARG A HG3    1 
ATOM   1123 H  HD2    . ARG A 1 83  ? 304.252 219.867 83.656  1.00 66.23 ? 83  ARG A HD2    1 
ATOM   1124 H  HD3    . ARG A 1 83  ? 304.000 218.382 83.144  1.00 65.05 ? 83  ARG A HD3    1 
ATOM   1125 H  HE     . ARG A 1 83  ? 302.005 218.539 83.976  1.00 68.78 ? 83  ARG A HE     1 
ATOM   1126 H  HH11   . ARG A 1 83  ? 303.776 220.759 85.700  1.00 66.46 ? 83  ARG A HH11   1 
ATOM   1127 H  HH12   . ARG A 1 83  ? 302.637 221.256 86.515  1.00 66.83 ? 83  ARG A HH12   1 
ATOM   1128 H  HH21   . ARG A 1 83  ? 300.321 219.296 85.240  1.00 68.80 ? 83  ARG A HH21   1 
ATOM   1129 H  HH22   . ARG A 1 83  ? 300.550 220.375 86.242  1.00 69.53 ? 83  ARG A HH22   1 
ATOM   1130 N  N      . ASN A 1 84  ? 307.417 217.473 86.948  1.00 54.85 ? 84  ASN A N      1 
ATOM   1131 C  CA     . ASN A 1 84  ? 308.033 218.042 88.141  1.00 54.28 ? 84  ASN A CA     1 
ATOM   1132 C  C      . ASN A 1 84  ? 308.630 216.972 89.038  1.00 51.24 ? 84  ASN A C      1 
ATOM   1133 O  O      . ASN A 1 84  ? 308.742 217.160 90.251  1.00 51.77 ? 84  ASN A O      1 
ATOM   1134 C  CB     . ASN A 1 84  ? 307.028 218.890 88.925  1.00 56.84 ? 84  ASN A CB     1 
ATOM   1135 C  CG     . ASN A 1 84  ? 306.950 220.310 88.420  1.00 62.14 ? 84  ASN A CG     1 
ATOM   1136 O  OD1    . ASN A 1 84  ? 307.686 220.701 87.515  1.00 66.75 ? 84  ASN A OD1    1 
ATOM   1137 N  ND2    . ASN A 1 84  ? 306.046 221.091 88.992  1.00 58.21 ? 84  ASN A ND2    1 
ATOM   1138 H  H      . ASN A 1 84  ? 307.783 217.734 86.218  1.00 55.15 ? 84  ASN A H      1 
ATOM   1139 H  HA     . ASN A 1 84  ? 308.758 218.623 87.870  1.00 55.33 ? 84  ASN A HA     1 
ATOM   1140 H  HB2    . ASN A 1 84  ? 306.149 218.495 88.837  1.00 55.64 ? 84  ASN A HB2    1 
ATOM   1141 H  HB3    . ASN A 1 84  ? 307.287 218.920 89.856  1.00 55.95 ? 84  ASN A HB3    1 
ATOM   1142 H  HD21   . ASN A 1 84  ? 305.546 220.781 89.621  1.00 57.31 ? 84  ASN A HD21   1 
ATOM   1143 H  HD22   . ASN A 1 84  ? 305.961 221.906 88.737  1.00 60.20 ? 84  ASN A HD22   1 
ATOM   1144 N  N      . THR A 1 85  ? 309.021 215.849 88.454  1.00 49.34 ? 85  THR A N      1 
ATOM   1145 C  CA     . THR A 1 85  ? 309.621 214.754 89.197  1.00 45.25 ? 85  THR A CA     1 
ATOM   1146 C  C      . THR A 1 85  ? 311.133 214.851 89.087  1.00 42.61 ? 85  THR A C      1 
ATOM   1147 O  O      . THR A 1 85  ? 311.687 214.838 87.981  1.00 42.79 ? 85  THR A O      1 
ATOM   1148 C  CB     . THR A 1 85  ? 309.100 213.419 88.672  1.00 43.79 ? 85  THR A CB     1 
ATOM   1149 O  OG1    . THR A 1 85  ? 307.811 213.164 89.234  1.00 43.93 ? 85  THR A OG1    1 
ATOM   1150 C  CG2    . THR A 1 85  ? 310.008 212.305 89.051  1.00 39.96 ? 85  THR A CG2    1 
ATOM   1151 H  H      . THR A 1 85  ? 308.947 215.695 87.616  1.00 49.03 ? 85  THR A H      1 
ATOM   1152 H  HA     . THR A 1 85  ? 309.384 214.825 90.129  1.00 45.84 ? 85  THR A HA     1 
ATOM   1153 H  HB     . THR A 1 85  ? 309.037 213.442 87.710  1.00 46.11 ? 85  THR A HB     1 
ATOM   1154 H  HG1    . THR A 1 85  ? 307.538 212.417 88.981  1.00 43.74 ? 85  THR A HG1    1 
ATOM   1155 H  HG21   . THR A 1 85  ? 310.884 212.434 88.662  1.00 42.03 ? 85  THR A HG21   1 
ATOM   1156 H  HG22   . THR A 1 85  ? 309.643 211.470 88.718  1.00 39.94 ? 85  THR A HG22   1 
ATOM   1157 H  HG23   . THR A 1 85  ? 310.070 212.277 90.017  1.00 39.53 ? 85  THR A HG23   1 
ATOM   1158 N  N      . GLU A 1 86  ? 311.804 214.917 90.236  1.00 40.60 ? 86  GLU A N      1 
ATOM   1159 C  CA     . GLU A 1 86  ? 313.236 215.135 90.289  1.00 38.69 ? 86  GLU A CA     1 
ATOM   1160 C  C      . GLU A 1 86  ? 314.018 213.841 90.441  1.00 37.54 ? 86  GLU A C      1 
ATOM   1161 O  O      . GLU A 1 86  ? 315.201 213.801 90.093  1.00 37.97 ? 86  GLU A O      1 
ATOM   1162 C  CB     . GLU A 1 86  ? 313.580 216.066 91.448  1.00 40.80 ? 86  GLU A CB     1 
ATOM   1163 C  CG     . GLU A 1 86  ? 313.082 217.495 91.304  1.00 47.49 ? 86  GLU A CG     1 
ATOM   1164 C  CD     . GLU A 1 86  ? 313.212 218.298 92.582  1.00 57.34 ? 86  GLU A CD     1 
ATOM   1165 O  OE1    . GLU A 1 86  ? 314.335 218.382 93.115  1.00 59.59 ? 86  GLU A OE1    1 
ATOM   1166 O  OE2    . GLU A 1 86  ? 312.194 218.846 93.052  1.00 58.39 ? 86  GLU A OE2    1 
ATOM   1167 H  H      . GLU A 1 86  ? 311.435 214.828 91.002  1.00 42.39 ? 86  GLU A H      1 
ATOM   1168 H  HA     . GLU A 1 86  ? 313.526 215.551 89.469  1.00 41.00 ? 86  GLU A HA     1 
ATOM   1169 H  HB2    . GLU A 1 86  ? 313.164 215.697 92.243  1.00 43.32 ? 86  GLU A HB2    1 
ATOM   1170 H  HB3    . GLU A 1 86  ? 314.540 216.089 91.560  1.00 43.39 ? 86  GLU A HB3    1 
ATOM   1171 H  HG2    . GLU A 1 86  ? 313.593 217.940 90.613  1.00 48.67 ? 86  GLU A HG2    1 
ATOM   1172 H  HG3    . GLU A 1 86  ? 312.147 217.473 91.073  1.00 46.07 ? 86  GLU A HG3    1 
ATOM   1173 N  N      . GLY A 1 87  ? 313.391 212.789 90.957  1.00 35.20 ? 87  GLY A N      1 
ATOM   1174 C  CA     . GLY A 1 87  ? 314.033 211.497 91.023  1.00 31.75 ? 87  GLY A CA     1 
ATOM   1175 C  C      . GLY A 1 87  ? 313.035 210.380 90.807  1.00 30.32 ? 87  GLY A C      1 
ATOM   1176 O  O      . GLY A 1 87  ? 311.835 210.524 91.056  1.00 33.43 ? 87  GLY A O      1 
ATOM   1177 H  H      . GLY A 1 87  ? 312.597 212.803 91.277  1.00 37.10 ? 87  GLY A H      1 
ATOM   1178 H  HA2    . GLY A 1 87  ? 314.719 211.428 90.347  1.00 33.57 ? 87  GLY A HA2    1 
ATOM   1179 H  HA3    . GLY A 1 87  ? 314.446 211.384 91.885  1.00 33.76 ? 87  GLY A HA3    1 
ATOM   1180 N  N      . VAL A 1 88  ? 313.558 209.251 90.348  1.00 28.72 ? 88  VAL A N      1 
ATOM   1181 C  CA     . VAL A 1 88  ? 312.761 208.059 90.113  1.00 29.36 ? 88  VAL A CA     1 
ATOM   1182 C  C      . VAL A 1 88  ? 313.436 206.877 90.781  1.00 27.78 ? 88  VAL A C      1 
ATOM   1183 O  O      . VAL A 1 88  ? 314.666 206.749 90.751  1.00 28.22 ? 88  VAL A O      1 
ATOM   1184 C  CB     . VAL A 1 88  ? 312.571 207.782 88.614  1.00 31.12 ? 88  VAL A CB     1 
ATOM   1185 C  CG1    . VAL A 1 88  ? 311.675 206.606 88.426  1.00 32.41 ? 88  VAL A CG1    1 
ATOM   1186 C  CG2    . VAL A 1 88  ? 311.989 208.975 87.944  1.00 35.71 ? 88  VAL A CG2    1 
ATOM   1187 H  H      . VAL A 1 88  ? 314.386 209.146 90.170  1.00 29.92 ? 88  VAL A H      1 
ATOM   1188 H  HA     . VAL A 1 88  ? 311.891 208.173 90.510  1.00 31.05 ? 88  VAL A HA     1 
ATOM   1189 H  HB     . VAL A 1 88  ? 313.426 207.585 88.219  1.00 30.46 ? 88  VAL A HB     1 
ATOM   1190 H  HG11   . VAL A 1 88  ? 312.127 205.820 88.759  1.00 31.77 ? 88  VAL A HG11   1 
ATOM   1191 H  HG12   . VAL A 1 88  ? 311.475 206.508 87.487  1.00 32.71 ? 88  VAL A HG12   1 
ATOM   1192 H  HG13   . VAL A 1 88  ? 310.862 206.757 88.922  1.00 31.01 ? 88  VAL A HG13   1 
ATOM   1193 H  HG21   . VAL A 1 88  ? 312.700 209.483 87.534  1.00 33.89 ? 88  VAL A HG21   1 
ATOM   1194 H  HG22   . VAL A 1 88  ? 311.538 209.505 88.614  1.00 33.83 ? 88  VAL A HG22   1 
ATOM   1195 H  HG23   . VAL A 1 88  ? 311.358 208.674 87.277  1.00 34.30 ? 88  VAL A HG23   1 
ATOM   1196 N  N      . ILE A 1 89  ? 312.619 206.006 91.360  1.00 26.94 ? 89  ILE A N      1 
ATOM   1197 C  CA     . ILE A 1 89  ? 313.068 204.809 92.046  1.00 28.59 ? 89  ILE A CA     1 
ATOM   1198 C  C      . ILE A 1 89  ? 312.346 203.639 91.408  1.00 29.76 ? 89  ILE A C      1 
ATOM   1199 O  O      . ILE A 1 89  ? 311.149 203.436 91.641  1.00 32.73 ? 89  ILE A O      1 
ATOM   1200 C  CB     . ILE A 1 89  ? 312.788 204.863 93.547  1.00 26.52 ? 89  ILE A CB     1 
ATOM   1201 C  CG1    . ILE A 1 89  ? 313.403 206.109 94.157  1.00 26.78 ? 89  ILE A CG1    1 
ATOM   1202 C  CG2    . ILE A 1 89  ? 313.353 203.660 94.210  1.00 26.76 ? 89  ILE A CG2    1 
ATOM   1203 C  CD1    . ILE A 1 89  ? 313.110 206.272 95.598  1.00 24.97 ? 89  ILE A CD1    1 
ATOM   1204 H  H      . ILE A 1 89  ? 311.768 206.084 91.356  1.00 28.87 ? 89  ILE A H      1 
ATOM   1205 H  HA     . ILE A 1 89  ? 314.014 204.694 91.918  1.00 28.65 ? 89  ILE A HA     1 
ATOM   1206 H  HB     . ILE A 1 89  ? 311.836 204.880 93.685  1.00 28.07 ? 89  ILE A HB     1 
ATOM   1207 H  HG12   . ILE A 1 89  ? 314.360 206.051 94.059  1.00 27.12 ? 89  ILE A HG12   1 
ATOM   1208 H  HG13   . ILE A 1 89  ? 313.061 206.884 93.692  1.00 28.15 ? 89  ILE A HG13   1 
ATOM   1209 H  HG21   . ILE A 1 89  ? 313.125 202.878 93.693  1.00 27.29 ? 89  ILE A HG21   1 
ATOM   1210 H  HG22   . ILE A 1 89  ? 312.981 203.589 95.098  1.00 27.88 ? 89  ILE A HG22   1 
ATOM   1211 H  HG23   . ILE A 1 89  ? 314.312 203.765 94.253  1.00 27.82 ? 89  ILE A HG23   1 
ATOM   1212 H  HD11   . ILE A 1 89  ? 313.460 205.512 96.077  1.00 24.61 ? 89  ILE A HD11   1 
ATOM   1213 H  HD12   . ILE A 1 89  ? 312.152 206.327 95.713  1.00 28.08 ? 89  ILE A HD12   1 
ATOM   1214 H  HD13   . ILE A 1 89  ? 313.532 207.081 95.913  1.00 25.94 ? 89  ILE A HD13   1 
ATOM   1215 N  N      . PHE A 1 90  ? 313.068 202.863 90.623  1.00 28.23 ? 90  PHE A N      1 
ATOM   1216 C  CA     . PHE A 1 90  ? 312.526 201.692 89.963  1.00 25.83 ? 90  PHE A CA     1 
ATOM   1217 C  C      . PHE A 1 90  ? 312.829 200.485 90.836  1.00 28.05 ? 90  PHE A C      1 
ATOM   1218 O  O      . PHE A 1 90  ? 313.994 200.139 91.044  1.00 31.13 ? 90  PHE A O      1 
ATOM   1219 C  CB     . PHE A 1 90  ? 313.125 201.543 88.572  1.00 30.01 ? 90  PHE A CB     1 
ATOM   1220 C  CG     . PHE A 1 90  ? 312.262 200.785 87.627  1.00 34.44 ? 90  PHE A CG     1 
ATOM   1221 C  CD1    . PHE A 1 90  ? 311.271 201.426 86.923  1.00 35.42 ? 90  PHE A CD1    1 
ATOM   1222 C  CD2    . PHE A 1 90  ? 312.434 199.436 87.444  1.00 32.63 ? 90  PHE A CD2    1 
ATOM   1223 C  CE1    . PHE A 1 90  ? 310.474 200.737 86.062  1.00 34.34 ? 90  PHE A CE1    1 
ATOM   1224 C  CE2    . PHE A 1 90  ? 311.637 198.747 86.583  1.00 33.31 ? 90  PHE A CE2    1 
ATOM   1225 C  CZ     . PHE A 1 90  ? 310.656 199.399 85.889  1.00 33.70 ? 90  PHE A CZ     1 
ATOM   1226 H  H      . PHE A 1 90  ? 313.897 202.991 90.450  1.00 29.50 ? 90  PHE A H      1 
ATOM   1227 H  HA     . PHE A 1 90  ? 311.571 201.784 89.883  1.00 28.24 ? 90  PHE A HA     1 
ATOM   1228 H  HB2    . PHE A 1 90  ? 313.263 202.426 88.209  1.00 30.20 ? 90  PHE A HB2    1 
ATOM   1229 H  HB3    . PHE A 1 90  ? 313.965 201.076 88.649  1.00 30.48 ? 90  PHE A HB3    1 
ATOM   1230 H  HD1    . PHE A 1 90  ? 311.143 202.336 87.037  1.00 32.95 ? 90  PHE A HD1    1 
ATOM   1231 H  HD2    . PHE A 1 90  ? 313.098 198.989 87.910  1.00 31.85 ? 90  PHE A HD2    1 
ATOM   1232 H  HE1    . PHE A 1 90  ? 309.810 201.180 85.592  1.00 33.29 ? 90  PHE A HE1    1 
ATOM   1233 H  HE2    . PHE A 1 90  ? 311.763 197.837 86.468  1.00 32.82 ? 90  PHE A HE2    1 
ATOM   1234 H  HZ     . PHE A 1 90  ? 310.113 198.932 85.304  1.00 33.46 ? 90  PHE A HZ     1 
ATOM   1235 N  N      . VAL A 1 91  ? 311.790 199.867 91.371  1.00 28.88 ? 91  VAL A N      1 
ATOM   1236 C  CA     . VAL A 1 91  ? 311.943 198.696 92.217  1.00 27.84 ? 91  VAL A CA     1 
ATOM   1237 C  C      . VAL A 1 91  ? 311.728 197.456 91.366  1.00 31.14 ? 91  VAL A C      1 
ATOM   1238 O  O      . VAL A 1 91  ? 310.738 197.363 90.632  1.00 33.93 ? 91  VAL A O      1 
ATOM   1239 C  CB     . VAL A 1 91  ? 310.952 198.731 93.388  1.00 26.91 ? 91  VAL A CB     1 
ATOM   1240 C  CG1    . VAL A 1 91  ? 311.420 197.849 94.480  1.00 27.82 ? 91  VAL A CG1    1 
ATOM   1241 C  CG2    . VAL A 1 91  ? 310.782 200.119 93.913  1.00 27.67 ? 91  VAL A CG2    1 
ATOM   1242 H  H      . VAL A 1 91  ? 310.978 200.112 91.265  1.00 29.61 ? 91  VAL A H      1 
ATOM   1243 H  HA     . VAL A 1 91  ? 312.837 198.667 92.573  1.00 28.21 ? 91  VAL A HA     1 
ATOM   1244 H  HB     . VAL A 1 91  ? 310.095 198.411 93.084  1.00 28.96 ? 91  VAL A HB     1 
ATOM   1245 H  HG11   . VAL A 1 91  ? 311.696 197.005 94.100  1.00 28.26 ? 91  VAL A HG11   1 
ATOM   1246 H  HG12   . VAL A 1 91  ? 310.694 197.722 95.103  1.00 29.22 ? 91  VAL A HG12   1 
ATOM   1247 H  HG13   . VAL A 1 91  ? 312.165 198.279 94.920  1.00 28.50 ? 91  VAL A HG13   1 
ATOM   1248 H  HG21   . VAL A 1 91  ? 311.632 200.432 94.245  1.00 28.09 ? 91  VAL A HG21   1 
ATOM   1249 H  HG22   . VAL A 1 91  ? 310.139 200.093 94.632  1.00 29.09 ? 91  VAL A HG22   1 
ATOM   1250 H  HG23   . VAL A 1 91  ? 310.459 200.694 93.210  1.00 28.84 ? 91  VAL A HG23   1 
ATOM   1251 N  N      . VAL A 1 92  ? 312.649 196.502 91.462  1.00 30.69 ? 92  VAL A N      1 
ATOM   1252 C  CA     . VAL A 1 92  ? 312.560 195.259 90.712  1.00 34.23 ? 92  VAL A CA     1 
ATOM   1253 C  C      . VAL A 1 92  ? 312.703 194.093 91.675  1.00 34.17 ? 92  VAL A C      1 
ATOM   1254 O  O      . VAL A 1 92  ? 313.616 194.063 92.506  1.00 37.15 ? 92  VAL A O      1 
ATOM   1255 C  CB     . VAL A 1 92  ? 313.621 195.168 89.598  1.00 32.71 ? 92  VAL A CB     1 
ATOM   1256 C  CG1    . VAL A 1 92  ? 313.405 196.247 88.578  1.00 36.34 ? 92  VAL A CG1    1 
ATOM   1257 C  CG2    . VAL A 1 92  ? 314.982 195.269 90.160  1.00 30.79 ? 92  VAL A CG2    1 
ATOM   1258 H  H      . VAL A 1 92  ? 313.341 196.548 91.963  1.00 31.04 ? 92  VAL A H      1 
ATOM   1259 H  HA     . VAL A 1 92  ? 311.688 195.206 90.304  1.00 33.20 ? 92  VAL A HA     1 
ATOM   1260 H  HB     . VAL A 1 92  ? 313.557 194.308 89.161  1.00 32.00 ? 92  VAL A HB     1 
ATOM   1261 H  HG11   . VAL A 1 92  ? 314.168 196.842 88.589  1.00 33.97 ? 92  VAL A HG11   1 
ATOM   1262 H  HG12   . VAL A 1 92  ? 312.599 196.731 88.805  1.00 34.57 ? 92  VAL A HG12   1 
ATOM   1263 H  HG13   . VAL A 1 92  ? 313.316 195.839 87.706  1.00 35.00 ? 92  VAL A HG13   1 
ATOM   1264 H  HG21   . VAL A 1 92  ? 315.607 195.267 89.424  1.00 30.82 ? 92  VAL A HG21   1 
ATOM   1265 H  HG22   . VAL A 1 92  ? 315.136 194.505 90.728  1.00 31.84 ? 92  VAL A HG22   1 
ATOM   1266 H  HG23   . VAL A 1 92  ? 315.050 196.089 90.664  1.00 32.16 ? 92  VAL A HG23   1 
ATOM   1267 N  N      . ASP A 1 93  ? 311.797 193.132 91.548  1.00 34.73 ? 93  ASP A N      1 
ATOM   1268 C  CA     . ASP A 1 93  ? 311.868 191.893 92.303  1.00 36.85 ? 93  ASP A CA     1 
ATOM   1269 C  C      . ASP A 1 93  ? 312.957 191.016 91.703  1.00 39.58 ? 93  ASP A C      1 
ATOM   1270 O  O      . ASP A 1 93  ? 312.914 190.682 90.515  1.00 44.58 ? 93  ASP A O      1 
ATOM   1271 C  CB     . ASP A 1 93  ? 310.511 191.196 92.283  1.00 38.40 ? 93  ASP A CB     1 
ATOM   1272 C  CG     . ASP A 1 93  ? 310.542 189.816 92.899  1.00 42.81 ? 93  ASP A CG     1 
ATOM   1273 O  OD1    . ASP A 1 93  ? 311.609 189.385 93.379  1.00 48.73 ? 93  ASP A OD1    1 
ATOM   1274 O  OD2    . ASP A 1 93  ? 309.478 189.163 92.917  1.00 39.69 ? 93  ASP A OD2    1 
ATOM   1275 H  H      . ASP A 1 93  ? 311.121 193.176 91.028  1.00 35.66 ? 93  ASP A H      1 
ATOM   1276 H  HA     . ASP A 1 93  ? 312.109 192.096 93.215  1.00 37.19 ? 93  ASP A HA     1 
ATOM   1277 H  HB2    . ASP A 1 93  ? 309.886 191.728 92.790  1.00 37.23 ? 93  ASP A HB2    1 
ATOM   1278 H  HB3    . ASP A 1 93  ? 310.210 191.110 91.371  1.00 38.76 ? 93  ASP A HB3    1 
ATOM   1279 N  N      . SER A 1 94  ? 313.936 190.651 92.527  1.00 35.02 ? 94  SER A N      1 
ATOM   1280 C  CA     . SER A 1 94  ? 315.048 189.847 92.044  1.00 39.84 ? 94  SER A CA     1 
ATOM   1281 C  C      . SER A 1 94  ? 314.654 188.382 91.916  1.00 46.46 ? 94  SER A C      1 
ATOM   1282 O  O      . SER A 1 94  ? 315.085 187.693 90.985  1.00 52.83 ? 94  SER A O      1 
ATOM   1283 C  CB     . SER A 1 94  ? 316.238 190.001 92.978  1.00 40.74 ? 94  SER A CB     1 
ATOM   1284 O  OG     . SER A 1 94  ? 316.578 191.359 93.133  1.00 38.33 ? 94  SER A OG     1 
ATOM   1285 H  H      . SER A 1 94  ? 313.986 190.859 93.354  1.00 37.75 ? 94  SER A H      1 
ATOM   1286 H  HA     . SER A 1 94  ? 315.306 190.177 91.173  1.00 40.55 ? 94  SER A HA     1 
ATOM   1287 H  HB2    . SER A 1 94  ? 316.010 189.626 93.838  1.00 41.55 ? 94  SER A HB2    1 
ATOM   1288 H  HB3    . SER A 1 94  ? 316.993 189.538 92.593  1.00 40.19 ? 94  SER A HB3    1 
ATOM   1289 H  HG     . SER A 1 94  ? 316.632 191.713 92.377  1.00 38.71 ? 94  SER A HG     1 
ATOM   1290 N  N      . ASN A 1 95  ? 313.833 187.887 92.840  1.00 43.02 ? 95  ASN A N      1 
ATOM   1291 C  CA     . ASN A 1 95  ? 313.387 186.502 92.754  1.00 46.10 ? 95  ASN A CA     1 
ATOM   1292 C  C      . ASN A 1 95  ? 312.593 186.256 91.479  1.00 52.31 ? 95  ASN A C      1 
ATOM   1293 O  O      . ASN A 1 95  ? 312.649 185.163 90.906  1.00 58.03 ? 95  ASN A O      1 
ATOM   1294 C  CB     . ASN A 1 95  ? 312.550 186.150 93.977  1.00 48.19 ? 95  ASN A CB     1 
ATOM   1295 C  CG     . ASN A 1 95  ? 312.385 184.661 94.159  1.00 54.17 ? 95  ASN A CG     1 
ATOM   1296 O  OD1    . ASN A 1 95  ? 311.518 184.041 93.544  1.00 60.08 ? 95  ASN A OD1    1 
ATOM   1297 N  ND2    . ASN A 1 95  ? 313.214 184.076 95.008  1.00 52.58 ? 95  ASN A ND2    1 
ATOM   1298 H  H      . ASN A 1 95  ? 313.533 188.320 93.517  1.00 44.22 ? 95  ASN A H      1 
ATOM   1299 H  HA     . ASN A 1 95  ? 314.160 185.924 92.743  1.00 47.47 ? 95  ASN A HA     1 
ATOM   1300 H  HB2    . ASN A 1 95  ? 312.990 186.497 94.768  1.00 48.67 ? 95  ASN A HB2    1 
ATOM   1301 H  HB3    . ASN A 1 95  ? 311.670 186.542 93.881  1.00 48.44 ? 95  ASN A HB3    1 
ATOM   1302 H  HD21   . ASN A 1 95  ? 313.804 184.545 95.419  1.00 51.48 ? 95  ASN A HD21   1 
ATOM   1303 H  HD22   . ASN A 1 95  ? 313.162 183.229 95.146  1.00 53.11 ? 95  ASN A HD22   1 
ATOM   1304 N  N      . ASP A 1 96  ? 311.848 187.259 91.020  1.00 50.34 ? 96  ASP A N      1 
ATOM   1305 C  CA     . ASP A 1 96  ? 311.073 187.130 89.794  1.00 50.64 ? 96  ASP A CA     1 
ATOM   1306 C  C      . ASP A 1 96  ? 311.994 187.259 88.594  1.00 53.50 ? 96  ASP A C      1 
ATOM   1307 O  O      . ASP A 1 96  ? 312.168 188.352 88.046  1.00 54.50 ? 96  ASP A O      1 
ATOM   1308 C  CB     . ASP A 1 96  ? 309.962 188.177 89.739  1.00 46.62 ? 96  ASP A CB     1 
ATOM   1309 C  CG     . ASP A 1 96  ? 308.710 187.666 89.057  1.00 47.62 ? 96  ASP A CG     1 
ATOM   1310 O  OD1    . ASP A 1 96  ? 308.181 188.372 88.174  1.00 47.70 ? 96  ASP A OD1    1 
ATOM   1311 O  OD2    . ASP A 1 96  ? 308.256 186.555 89.401  1.00 47.82 ? 96  ASP A OD2    1 
ATOM   1312 H  H      . ASP A 1 96  ? 311.776 188.023 91.403  1.00 48.03 ? 96  ASP A H      1 
ATOM   1313 H  HA     . ASP A 1 96  ? 310.665 186.259 89.769  1.00 50.63 ? 96  ASP A HA     1 
ATOM   1314 H  HB2    . ASP A 1 96  ? 309.728 188.438 90.640  1.00 46.80 ? 96  ASP A HB2    1 
ATOM   1315 H  HB3    . ASP A 1 96  ? 310.277 188.942 89.237  1.00 47.10 ? 96  ASP A HB3    1 
ATOM   1316 N  N      . ARG A 1 97  ? 312.599 186.147 88.184  1.00 53.35 ? 97  ARG A N      1 
ATOM   1317 C  CA     . ARG A 1 97  ? 313.547 186.141 87.083  1.00 52.23 ? 97  ARG A CA     1 
ATOM   1318 C  C      . ARG A 1 97  ? 312.856 185.941 85.741  1.00 51.93 ? 97  ARG A C      1 
ATOM   1319 O  O      . ARG A 1 97  ? 313.511 185.993 84.697  1.00 56.74 ? 97  ARG A O      1 
ATOM   1320 C  CB     . ARG A 1 97  ? 314.598 185.057 87.320  1.00 51.97 ? 97  ARG A CB     1 
ATOM   1321 C  CG     . ARG A 1 97  ? 315.843 185.178 86.478  1.00 55.25 ? 97  ARG A CG     1 
ATOM   1322 C  CD     . ARG A 1 97  ? 316.745 183.971 86.655  1.00 57.94 ? 97  ARG A CD     1 
ATOM   1323 N  NE     . ARG A 1 97  ? 317.703 184.128 87.742  1.00 59.70 ? 97  ARG A NE     1 
ATOM   1324 C  CZ     . ARG A 1 97  ? 317.459 183.838 89.012  1.00 57.84 ? 97  ARG A CZ     1 
ATOM   1325 N  NH1    . ARG A 1 97  ? 316.272 183.414 89.410  1.00 56.62 ? 97  ARG A NH1    1 
ATOM   1326 N  NH2    . ARG A 1 97  ? 318.431 183.982 89.907  1.00 55.05 ? 97  ARG A NH2    1 
ATOM   1327 H  H      . ARG A 1 97  ? 312.472 185.373 88.534  1.00 52.86 ? 97  ARG A H      1 
ATOM   1328 H  HA     . ARG A 1 97  ? 314.004 186.992 87.055  1.00 53.36 ? 97  ARG A HA     1 
ATOM   1329 H  HB2    . ARG A 1 97  ? 314.871 185.097 88.248  1.00 52.54 ? 97  ARG A HB2    1 
ATOM   1330 H  HB3    . ARG A 1 97  ? 314.197 184.197 87.133  1.00 53.52 ? 97  ARG A HB3    1 
ATOM   1331 H  HG2    . ARG A 1 97  ? 315.591 185.235 85.545  1.00 55.02 ? 97  ARG A HG2    1 
ATOM   1332 H  HG3    . ARG A 1 97  ? 316.332 185.970 86.748  1.00 55.58 ? 97  ARG A HG3    1 
ATOM   1333 H  HD2    . ARG A 1 97  ? 316.198 183.194 86.845  1.00 56.15 ? 97  ARG A HD2    1 
ATOM   1334 H  HD3    . ARG A 1 97  ? 317.249 183.832 85.840  1.00 57.56 ? 97  ARG A HD3    1 
ATOM   1335 H  HE     . ARG A 1 97  ? 318.517 184.310 87.533  1.00 58.03 ? 97  ARG A HE     1 
ATOM   1336 H  HH11   . ARG A 1 97  ? 315.635 183.314 88.844  1.00 55.73 ? 97  ARG A HH11   1 
ATOM   1337 H  HH12   . ARG A 1 97  ? 316.139 183.237 90.240  1.00 56.38 ? 97  ARG A HH12   1 
ATOM   1338 H  HH21   . ARG A 1 97  ? 319.204 184.257 89.655  1.00 55.88 ? 97  ARG A HH21   1 
ATOM   1339 H  HH22   . ARG A 1 97  ? 318.285 183.804 90.734  1.00 54.98 ? 97  ARG A HH22   1 
ATOM   1340 N  N      . SER A 1 98  ? 311.541 185.728 85.756  1.00 50.52 ? 98  SER A N      1 
ATOM   1341 C  CA     . SER A 1 98  ? 310.758 185.539 84.548  1.00 49.91 ? 98  SER A CA     1 
ATOM   1342 C  C      . SER A 1 98  ? 310.155 186.822 84.008  1.00 50.53 ? 98  SER A C      1 
ATOM   1343 O  O      . SER A 1 98  ? 309.707 186.836 82.857  1.00 53.36 ? 98  SER A O      1 
ATOM   1344 C  CB     . SER A 1 98  ? 309.623 184.538 84.804  1.00 46.46 ? 98  SER A CB     1 
ATOM   1345 O  OG     . SER A 1 98  ? 308.877 184.905 85.952  1.00 48.19 ? 98  SER A OG     1 
ATOM   1346 H  H      . SER A 1 98  ? 311.075 185.686 86.473  1.00 51.23 ? 98  SER A H      1 
ATOM   1347 H  HA     . SER A 1 98  ? 311.331 185.173 83.859  1.00 50.33 ? 98  SER A HA     1 
ATOM   1348 H  HB2    . SER A 1 98  ? 309.032 184.531 84.037  1.00 47.30 ? 98  SER A HB2    1 
ATOM   1349 H  HB3    . SER A 1 98  ? 310.003 183.658 84.944  1.00 48.24 ? 98  SER A HB3    1 
ATOM   1350 H  HG     . SER A 1 98  ? 308.314 184.308 86.132  1.00 48.48 ? 98  SER A HG     1 
ATOM   1351 N  N      . ARG A 1 99  ? 310.134 187.896 84.796  1.00 48.28 ? 99  ARG A N      1 
ATOM   1352 C  CA     . ARG A 1 99  ? 309.555 189.164 84.377  1.00 45.08 ? 99  ARG A CA     1 
ATOM   1353 C  C      . ARG A 1 99  ? 310.606 190.257 84.267  1.00 47.31 ? 99  ARG A C      1 
ATOM   1354 O  O      . ARG A 1 99  ? 310.259 191.437 84.168  1.00 48.89 ? 99  ARG A O      1 
ATOM   1355 C  CB     . ARG A 1 99  ? 308.460 189.594 85.346  1.00 44.06 ? 99  ARG A CB     1 
ATOM   1356 C  CG     . ARG A 1 99  ? 307.277 188.671 85.356  1.00 48.34 ? 99  ARG A CG     1 
ATOM   1357 C  CD     . ARG A 1 99  ? 306.057 189.380 85.848  1.00 48.84 ? 99  ARG A CD     1 
ATOM   1358 N  NE     . ARG A 1 99  ? 306.204 189.778 87.237  1.00 45.88 ? 99  ARG A NE     1 
ATOM   1359 C  CZ     . ARG A 1 99  ? 305.422 190.657 87.844  1.00 43.17 ? 99  ARG A CZ     1 
ATOM   1360 N  NH1    . ARG A 1 99  ? 304.445 191.268 87.199  1.00 40.46 ? 99  ARG A NH1    1 
ATOM   1361 N  NH2    . ARG A 1 99  ? 305.633 190.936 89.125  1.00 42.99 ? 99  ARG A NH2    1 
ATOM   1362 H  H      . ARG A 1 99  ? 310.454 187.915 85.591  1.00 49.07 ? 99  ARG A H      1 
ATOM   1363 H  HA     . ARG A 1 99  ? 309.154 189.050 83.506  1.00 46.77 ? 99  ARG A HA     1 
ATOM   1364 H  HB2    . ARG A 1 99  ? 308.828 189.615 86.240  1.00 45.25 ? 99  ARG A HB2    1 
ATOM   1365 H  HB3    . ARG A 1 99  ? 308.154 190.474 85.094  1.00 45.72 ? 99  ARG A HB3    1 
ATOM   1366 H  HG2    . ARG A 1 99  ? 307.109 188.354 84.458  1.00 47.69 ? 99  ARG A HG2    1 
ATOM   1367 H  HG3    . ARG A 1 99  ? 307.458 187.932 85.952  1.00 48.03 ? 99  ARG A HG3    1 
ATOM   1368 H  HD2    . ARG A 1 99  ? 305.912 190.177 85.319  1.00 46.54 ? 99  ARG A HD2    1 
ATOM   1369 H  HD3    . ARG A 1 99  ? 305.294 188.787 85.779  1.00 47.83 ? 99  ARG A HD3    1 
ATOM   1370 H  HE     . ARG A 1 99  ? 306.861 189.447 87.677  1.00 45.68 ? 99  ARG A HE     1 
ATOM   1371 H  HH11   . ARG A 1 99  ? 304.305 191.094 86.372  1.00 41.48 ? 99  ARG A HH11   1 
ATOM   1372 H  HH12   . ARG A 1 99  ? 303.952 191.835 87.607  1.00 41.32 ? 99  ARG A HH12   1 
ATOM   1373 H  HH21   . ARG A 1 99  ? 306.267 190.549 89.557  1.00 42.34 ? 99  ARG A HH21   1 
ATOM   1374 H  HH22   . ARG A 1 99  ? 305.131 191.506 89.520  1.00 40.96 ? 99  ARG A HH22   1 
ATOM   1375 N  N      . ILE A 1 100 ? 311.888 189.889 84.298  1.00 46.51 ? 100 ILE A N      1 
ATOM   1376 C  CA     . ILE A 1 100 ? 312.962 190.866 84.158  1.00 42.59 ? 100 ILE A CA     1 
ATOM   1377 C  C      . ILE A 1 100 ? 313.000 191.489 82.774  1.00 43.74 ? 100 ILE A C      1 
ATOM   1378 O  O      . ILE A 1 100 ? 313.613 192.549 82.600  1.00 48.57 ? 100 ILE A O      1 
ATOM   1379 C  CB     . ILE A 1 100 ? 314.308 190.194 84.483  1.00 44.16 ? 100 ILE A CB     1 
ATOM   1380 C  CG1    . ILE A 1 100 ? 315.395 191.243 84.685  1.00 43.30 ? 100 ILE A CG1    1 
ATOM   1381 C  CG2    . ILE A 1 100 ? 314.684 189.239 83.384  1.00 47.04 ? 100 ILE A CG2    1 
ATOM   1382 C  CD1    . ILE A 1 100 ? 315.176 192.087 85.885  1.00 42.18 ? 100 ILE A CD1    1 
ATOM   1383 H  H      . ILE A 1 100 ? 312.161 189.084 84.403  1.00 47.21 ? 100 ILE A H      1 
ATOM   1384 H  HA     . ILE A 1 100 ? 312.821 191.573 84.801  1.00 43.74 ? 100 ILE A HA     1 
ATOM   1385 H  HB     . ILE A 1 100 ? 314.206 189.697 85.305  1.00 45.83 ? 100 ILE A HB     1 
ATOM   1386 H  HG12   . ILE A 1 100 ? 316.246 190.795 84.793  1.00 44.21 ? 100 ILE A HG12   1 
ATOM   1387 H  HG13   . ILE A 1 100 ? 315.420 191.823 83.914  1.00 44.16 ? 100 ILE A HG13   1 
ATOM   1388 H  HG21   . ILE A 1 100 ? 315.194 189.720 82.715  1.00 45.69 ? 100 ILE A HG21   1 
ATOM   1389 H  HG22   . ILE A 1 100 ? 313.875 188.884 82.989  1.00 47.49 ? 100 ILE A HG22   1 
ATOM   1390 H  HG23   . ILE A 1 100 ? 315.217 188.522 83.760  1.00 47.43 ? 100 ILE A HG23   1 
ATOM   1391 H  HD11   . ILE A 1 100 ? 314.632 192.844 85.628  1.00 42.53 ? 100 ILE A HD11   1 
ATOM   1392 H  HD12   . ILE A 1 100 ? 316.032 192.387 86.224  1.00 41.96 ? 100 ILE A HD12   1 
ATOM   1393 H  HD13   . ILE A 1 100 ? 314.721 191.560 86.558  1.00 44.05 ? 100 ILE A HD13   1 
ATOM   1394 N  N      . GLY A 1 101 ? 312.371 190.867 81.784  1.00 42.05 ? 101 GLY A N      1 
ATOM   1395 C  CA     . GLY A 1 101 ? 312.289 191.443 80.460  1.00 41.57 ? 101 GLY A CA     1 
ATOM   1396 C  C      . GLY A 1 101 ? 311.188 192.472 80.341  1.00 44.96 ? 101 GLY A C      1 
ATOM   1397 O  O      . GLY A 1 101 ? 311.344 193.490 79.662  1.00 51.17 ? 101 GLY A O      1 
ATOM   1398 H  H      . GLY A 1 101 ? 311.989 190.103 81.859  1.00 44.64 ? 101 GLY A H      1 
ATOM   1399 H  HA2    . GLY A 1 101 ? 313.128 191.868 80.244  1.00 43.91 ? 101 GLY A HA2    1 
ATOM   1400 H  HA3    . GLY A 1 101 ? 312.117 190.745 79.814  1.00 43.00 ? 101 GLY A HA3    1 
ATOM   1401 N  N      . GLU A 1 102 ? 310.063 192.212 81.000  1.00 42.02 ? 102 GLU A N      1 
ATOM   1402 C  CA     . GLU A 1 102 ? 308.976 193.176 81.049  1.00 43.09 ? 102 GLU A CA     1 
ATOM   1403 C  C      . GLU A 1 102 ? 309.387 194.465 81.743  1.00 43.29 ? 102 GLU A C      1 
ATOM   1404 O  O      . GLU A 1 102 ? 309.049 195.554 81.263  1.00 44.88 ? 102 GLU A O      1 
ATOM   1405 C  CB     . GLU A 1 102 ? 307.782 192.552 81.767  1.00 45.11 ? 102 GLU A CB     1 
ATOM   1406 C  CG     . GLU A 1 102 ? 306.502 193.338 81.671  1.00 46.27 ? 102 GLU A CG     1 
ATOM   1407 C  CD     . GLU A 1 102 ? 305.365 192.677 82.421  1.00 54.01 ? 102 GLU A CD     1 
ATOM   1408 O  OE1    . GLU A 1 102 ? 305.580 191.588 82.992  1.00 51.65 ? 102 GLU A OE1    1 
ATOM   1409 O  OE2    . GLU A 1 102 ? 304.253 193.244 82.438  1.00 59.03 ? 102 GLU A OE2    1 
ATOM   1410 H  H      . GLU A 1 102 ? 309.908 191.484 81.425  1.00 44.05 ? 102 GLU A H      1 
ATOM   1411 H  HA     . GLU A 1 102 ? 308.706 193.396 80.148  1.00 43.86 ? 102 GLU A HA     1 
ATOM   1412 H  HB2    . GLU A 1 102 ? 307.622 191.674 81.394  1.00 45.99 ? 102 GLU A HB2    1 
ATOM   1413 H  HB3    . GLU A 1 102 ? 308.003 192.472 82.703  1.00 45.62 ? 102 GLU A HB3    1 
ATOM   1414 H  HG2    . GLU A 1 102 ? 306.645 194.220 82.041  1.00 45.62 ? 102 GLU A HG2    1 
ATOM   1415 H  HG3    . GLU A 1 102 ? 306.248 193.406 80.740  1.00 47.50 ? 102 GLU A HG3    1 
ATOM   1416 N  N      . ALA A 1 103 ? 310.111 194.362 82.851  1.00 41.09 ? 103 ALA A N      1 
ATOM   1417 C  CA     . ALA A 1 103 ? 310.667 195.523 83.524  1.00 40.21 ? 103 ALA A CA     1 
ATOM   1418 C  C      . ALA A 1 103 ? 311.634 196.290 82.645  1.00 39.00 ? 103 ALA A C      1 
ATOM   1419 O  O      . ALA A 1 103 ? 311.641 197.524 82.671  1.00 42.54 ? 103 ALA A O      1 
ATOM   1420 C  CB     . ALA A 1 103 ? 311.380 195.085 84.795  1.00 38.88 ? 103 ALA A CB     1 
ATOM   1421 H  H      . ALA A 1 103 ? 310.300 193.622 83.235  1.00 42.35 ? 103 ALA A H      1 
ATOM   1422 H  HA     . ALA A 1 103 ? 309.951 196.120 83.768  1.00 40.92 ? 103 ALA A HA     1 
ATOM   1423 H  HB1    . ALA A 1 103 ? 311.823 195.851 85.183  1.00 38.27 ? 103 ALA A HB1    1 
ATOM   1424 H  HB2    . ALA A 1 103 ? 312.024 194.405 84.554  1.00 40.83 ? 103 ALA A HB2    1 
ATOM   1425 H  HB3    . ALA A 1 103 ? 310.728 194.724 85.409  1.00 40.57 ? 103 ALA A HB3    1 
ATOM   1426 N  N      . ARG A 1 104 ? 312.450 195.583 81.867  1.00 37.15 ? 104 ARG A N      1 
ATOM   1427 C  CA     . ARG A 1 104 ? 313.331 196.251 80.922  1.00 38.78 ? 104 ARG A CA     1 
ATOM   1428 C  C      . ARG A 1 104 ? 312.545 197.037 79.886  1.00 43.17 ? 104 ARG A C      1 
ATOM   1429 O  O      . ARG A 1 104 ? 312.915 198.167 79.556  1.00 46.39 ? 104 ARG A O      1 
ATOM   1430 C  CB     . ARG A 1 104 ? 314.217 195.221 80.240  1.00 38.99 ? 104 ARG A CB     1 
ATOM   1431 C  CG     . ARG A 1 104 ? 315.375 195.803 79.491  1.00 41.54 ? 104 ARG A CG     1 
ATOM   1432 C  CD     . ARG A 1 104 ? 316.074 194.747 78.672  1.00 45.67 ? 104 ARG A CD     1 
ATOM   1433 N  NE     . ARG A 1 104 ? 317.405 195.171 78.260  1.00 46.74 ? 104 ARG A NE     1 
ATOM   1434 C  CZ     . ARG A 1 104 ? 317.641 196.123 77.369  1.00 47.10 ? 104 ARG A CZ     1 
ATOM   1435 N  NH1    . ARG A 1 104 ? 316.655 196.772 76.776  1.00 44.35 ? 104 ARG A NH1    1 
ATOM   1436 N  NH2    . ARG A 1 104 ? 318.897 196.431 77.070  1.00 45.89 ? 104 ARG A NH2    1 
ATOM   1437 H  H      . ARG A 1 104 ? 312.507 194.728 81.869  1.00 40.49 ? 104 ARG A H      1 
ATOM   1438 H  HA     . ARG A 1 104 ? 313.897 196.870 81.395  1.00 40.04 ? 104 ARG A HA     1 
ATOM   1439 H  HB2    . ARG A 1 104 ? 314.567 194.625 80.913  1.00 40.35 ? 104 ARG A HB2    1 
ATOM   1440 H  HB3    . ARG A 1 104 ? 313.678 194.729 79.608  1.00 41.80 ? 104 ARG A HB3    1 
ATOM   1441 H  HG2    . ARG A 1 104 ? 315.050 196.491 78.895  1.00 42.80 ? 104 ARG A HG2    1 
ATOM   1442 H  HG3    . ARG A 1 104 ? 316.007 196.171 80.120  1.00 42.64 ? 104 ARG A HG3    1 
ATOM   1443 H  HD2    . ARG A 1 104 ? 316.163 193.941 79.202  1.00 44.96 ? 104 ARG A HD2    1 
ATOM   1444 H  HD3    . ARG A 1 104 ? 315.555 194.569 77.875  1.00 45.40 ? 104 ARG A HD3    1 
ATOM   1445 H  HE     . ARG A 1 104 ? 318.053 194.636 78.433  1.00 45.75 ? 104 ARG A HE     1 
ATOM   1446 H  HH11   . ARG A 1 104 ? 315.839 196.581 76.962  1.00 43.98 ? 104 ARG A HH11   1 
ATOM   1447 H  HH12   . ARG A 1 104 ? 316.832 197.386 76.202  1.00 44.22 ? 104 ARG A HH12   1 
ATOM   1448 H  HH21   . ARG A 1 104 ? 319.545 196.014 77.450  1.00 46.17 ? 104 ARG A HH21   1 
ATOM   1449 H  HH22   . ARG A 1 104 ? 319.062 197.047 76.495  1.00 45.77 ? 104 ARG A HH22   1 
ATOM   1450 N  N      . GLU A 1 105 ? 311.467 196.456 79.361  1.00 42.63 ? 105 GLU A N      1 
ATOM   1451 C  CA     . GLU A 1 105 ? 310.613 197.179 78.428  1.00 43.35 ? 105 GLU A CA     1 
ATOM   1452 C  C      . GLU A 1 105 ? 310.053 198.436 79.070  1.00 43.87 ? 105 GLU A C      1 
ATOM   1453 O  O      . GLU A 1 105 ? 310.125 199.530 78.497  1.00 46.73 ? 105 GLU A O      1 
ATOM   1454 C  CB     . GLU A 1 105 ? 309.475 196.279 77.957  1.00 48.55 ? 105 GLU A CB     1 
ATOM   1455 C  CG     . GLU A 1 105 ? 309.890 195.126 77.068  1.00 53.25 ? 105 GLU A CG     1 
ATOM   1456 C  CD     . GLU A 1 105 ? 308.734 194.202 76.731  1.00 59.86 ? 105 GLU A CD     1 
ATOM   1457 O  OE1    . GLU A 1 105 ? 307.569 194.629 76.873  1.00 56.57 ? 105 GLU A OE1    1 
ATOM   1458 O  OE2    . GLU A 1 105 ? 308.990 193.048 76.325  1.00 64.36 ? 105 GLU A OE2    1 
ATOM   1459 H  H      . GLU A 1 105 ? 311.214 195.656 79.528  1.00 44.20 ? 105 GLU A H      1 
ATOM   1460 H  HA     . GLU A 1 105 ? 311.133 197.434 77.657  1.00 44.65 ? 105 GLU A HA     1 
ATOM   1461 H  HB2    . GLU A 1 105 ? 309.054 195.898 78.739  1.00 47.80 ? 105 GLU A HB2    1 
ATOM   1462 H  HB3    . GLU A 1 105 ? 308.833 196.819 77.473  1.00 49.23 ? 105 GLU A HB3    1 
ATOM   1463 H  HG2    . GLU A 1 105 ? 310.249 195.479 76.240  1.00 53.51 ? 105 GLU A HG2    1 
ATOM   1464 H  HG3    . GLU A 1 105 ? 310.564 194.605 77.525  1.00 49.68 ? 105 GLU A HG3    1 
ATOM   1465 N  N      . VAL A 1 106 ? 309.499 198.301 80.275  1.00 40.06 ? 106 VAL A N      1 
ATOM   1466 C  CA     . VAL A 1 106 ? 308.880 199.441 80.940  1.00 38.77 ? 106 VAL A CA     1 
ATOM   1467 C  C      . VAL A 1 106 ? 309.903 200.542 81.175  1.00 39.03 ? 106 VAL A C      1 
ATOM   1468 O  O      . VAL A 1 106 ? 309.627 201.727 80.954  1.00 42.34 ? 106 VAL A O      1 
ATOM   1469 C  CB     . VAL A 1 106 ? 308.226 198.990 82.256  1.00 39.91 ? 106 VAL A CB     1 
ATOM   1470 C  CG1    . VAL A 1 106 ? 307.734 200.165 83.023  1.00 39.92 ? 106 VAL A CG1    1 
ATOM   1471 C  CG2    . VAL A 1 106 ? 307.093 198.056 81.983  1.00 40.51 ? 106 VAL A CG2    1 
ATOM   1472 H  H      . VAL A 1 106 ? 309.477 197.573 80.722  1.00 41.73 ? 106 VAL A H      1 
ATOM   1473 H  HA     . VAL A 1 106 ? 308.192 199.800 80.370  1.00 39.69 ? 106 VAL A HA     1 
ATOM   1474 H  HB     . VAL A 1 106 ? 308.875 198.526 82.797  1.00 40.32 ? 106 VAL A HB     1 
ATOM   1475 H  HG11   . VAL A 1 106 ? 306.995 199.882 83.580  1.00 37.91 ? 106 VAL A HG11   1 
ATOM   1476 H  HG12   . VAL A 1 106 ? 307.448 200.838 82.389  1.00 39.26 ? 106 VAL A HG12   1 
ATOM   1477 H  HG13   . VAL A 1 106 ? 308.455 200.497 83.575  1.00 38.18 ? 106 VAL A HG13   1 
ATOM   1478 H  HG21   . VAL A 1 106 ? 307.419 197.313 81.460  1.00 41.43 ? 106 VAL A HG21   1 
ATOM   1479 H  HG22   . VAL A 1 106 ? 306.410 198.541 81.496  1.00 39.90 ? 106 VAL A HG22   1 
ATOM   1480 H  HG23   . VAL A 1 106 ? 306.745 197.740 82.829  1.00 39.97 ? 106 VAL A HG23   1 
ATOM   1481 N  N      . MET A 1 107 ? 311.106 200.168 81.602  1.00 37.76 ? 107 MET A N      1 
ATOM   1482 C  CA     . MET A 1 107 ? 312.103 201.165 81.954  1.00 36.72 ? 107 MET A CA     1 
ATOM   1483 C  C      . MET A 1 107 ? 312.674 201.835 80.712  1.00 39.38 ? 107 MET A C      1 
ATOM   1484 O  O      . MET A 1 107 ? 312.918 203.045 80.715  1.00 43.18 ? 107 MET A O      1 
ATOM   1485 C  CB     . MET A 1 107 ? 313.210 200.521 82.779  1.00 37.23 ? 107 MET A CB     1 
ATOM   1486 C  CG     . MET A 1 107 ? 314.001 201.504 83.610  1.00 41.31 ? 107 MET A CG     1 
ATOM   1487 S  SD     . MET A 1 107 ? 315.563 200.894 84.257  1.00 44.37 ? 107 MET A SD     1 
ATOM   1488 C  CE     . MET A 1 107 ? 316.304 200.203 82.787  1.00 40.07 ? 107 MET A CE     1 
ATOM   1489 H  H      . MET A 1 107 ? 311.370 199.361 81.693  1.00 39.61 ? 107 MET A H      1 
ATOM   1490 H  HA     . MET A 1 107 ? 311.676 201.833 82.501  1.00 38.23 ? 107 MET A HA     1 
ATOM   1491 H  HB2    . MET A 1 107 ? 312.809 199.883 83.385  1.00 38.23 ? 107 MET A HB2    1 
ATOM   1492 H  HB3    . MET A 1 107 ? 313.811 200.066 82.185  1.00 38.31 ? 107 MET A HB3    1 
ATOM   1493 H  HG2    . MET A 1 107 ? 314.201 202.276 83.063  1.00 41.11 ? 107 MET A HG2    1 
ATOM   1494 H  HG3    . MET A 1 107 ? 313.454 201.767 84.361  1.00 40.05 ? 107 MET A HG3    1 
ATOM   1495 H  HE1    . MET A 1 107 ? 315.746 199.495 82.439  1.00 40.23 ? 107 MET A HE1    1 
ATOM   1496 H  HE2    . MET A 1 107 ? 317.177 199.858 83.022  1.00 42.38 ? 107 MET A HE2    1 
ATOM   1497 H  HE3    . MET A 1 107 ? 316.384 200.903 82.124  1.00 41.04 ? 107 MET A HE3    1 
ATOM   1498 N  N      . GLN A 1 108 ? 312.878 201.077 79.635  1.00 40.51 ? 108 GLN A N      1 
ATOM   1499 C  CA     . GLN A 1 108 ? 313.361 201.693 78.410  1.00 40.39 ? 108 GLN A CA     1 
ATOM   1500 C  C      . GLN A 1 108 ? 312.299 202.573 77.776  1.00 42.04 ? 108 GLN A C      1 
ATOM   1501 O  O      . GLN A 1 108 ? 312.631 203.520 77.057  1.00 47.45 ? 108 GLN A O      1 
ATOM   1502 C  CB     . GLN A 1 108 ? 313.809 200.615 77.433  1.00 42.07 ? 108 GLN A CB     1 
ATOM   1503 C  CG     . GLN A 1 108 ? 315.139 199.988 77.771  1.00 44.25 ? 108 GLN A CG     1 
ATOM   1504 C  CD     . GLN A 1 108 ? 316.261 200.986 77.866  1.00 52.59 ? 108 GLN A CD     1 
ATOM   1505 O  OE1    . GLN A 1 108 ? 316.256 202.013 77.187  1.00 54.43 ? 108 GLN A OE1    1 
ATOM   1506 N  NE2    . GLN A 1 108 ? 317.230 200.700 78.724  1.00 48.29 ? 108 GLN A NE2    1 
ATOM   1507 H  H      . GLN A 1 108 ? 312.745 200.233 79.588  1.00 41.90 ? 108 GLN A H      1 
ATOM   1508 H  HA     . GLN A 1 108 ? 314.117 202.253 78.619  1.00 43.06 ? 108 GLN A HA     1 
ATOM   1509 H  HB2    . GLN A 1 108 ? 313.150 199.909 77.457  1.00 42.73 ? 108 GLN A HB2    1 
ATOM   1510 H  HB3    . GLN A 1 108 ? 313.861 200.989 76.542  1.00 43.92 ? 108 GLN A HB3    1 
ATOM   1511 H  HG2    . GLN A 1 108 ? 315.064 199.562 78.633  1.00 44.11 ? 108 GLN A HG2    1 
ATOM   1512 H  HG3    . GLN A 1 108 ? 315.370 199.339 77.090  1.00 44.38 ? 108 GLN A HG3    1 
ATOM   1513 H  HE21   . GLN A 1 108 ? 317.195 199.974 79.185  1.00 46.65 ? 108 GLN A HE21   1 
ATOM   1514 H  HE22   . GLN A 1 108 ? 317.891 201.236 78.818  1.00 48.74 ? 108 GLN A HE22   1 
ATOM   1515 N  N      . ARG A 1 109 ? 311.023 202.271 78.008  1.00 41.24 ? 109 ARG A N      1 
ATOM   1516 C  CA     . ARG A 1 109 ? 309.973 203.164 77.540  1.00 41.22 ? 109 ARG A CA     1 
ATOM   1517 C  C      . ARG A 1 109 ? 309.940 204.443 78.355  1.00 41.08 ? 109 ARG A C      1 
ATOM   1518 O  O      . ARG A 1 109 ? 309.781 205.534 77.800  1.00 44.58 ? 109 ARG A O      1 
ATOM   1519 C  CB     . ARG A 1 109 ? 308.624 202.464 77.611  1.00 45.43 ? 109 ARG A CB     1 
ATOM   1520 C  CG     . ARG A 1 109 ? 307.466 203.315 77.159  1.00 48.89 ? 109 ARG A CG     1 
ATOM   1521 C  CD     . ARG A 1 109 ? 306.141 202.590 77.279  1.00 51.48 ? 109 ARG A CD     1 
ATOM   1522 N  NE     . ARG A 1 109 ? 306.243 201.184 76.904  1.00 59.19 ? 109 ARG A NE     1 
ATOM   1523 C  CZ     . ARG A 1 109 ? 305.823 200.165 77.643  1.00 61.23 ? 109 ARG A CZ     1 
ATOM   1524 N  NH1    . ARG A 1 109 ? 305.195 200.350 78.792  1.00 58.99 ? 109 ARG A NH1    1 
ATOM   1525 N  NH2    . ARG A 1 109 ? 306.025 198.924 77.208  1.00 56.96 ? 109 ARG A NH2    1 
ATOM   1526 H  H      . ARG A 1 109 ? 310.749 201.570 78.416  1.00 42.52 ? 109 ARG A H      1 
ATOM   1527 H  HA     . ARG A 1 109 ? 310.141 203.402 76.620  1.00 42.76 ? 109 ARG A HA     1 
ATOM   1528 H  HB2    . ARG A 1 109 ? 308.660 201.682 77.044  1.00 45.86 ? 109 ARG A HB2    1 
ATOM   1529 H  HB3    . ARG A 1 109 ? 308.457 202.210 78.530  1.00 45.49 ? 109 ARG A HB3    1 
ATOM   1530 H  HG2    . ARG A 1 109 ? 307.421 204.106 77.714  1.00 47.30 ? 109 ARG A HG2    1 
ATOM   1531 H  HG3    . ARG A 1 109 ? 307.597 203.561 76.234  1.00 49.96 ? 109 ARG A HG3    1 
ATOM   1532 H  HD2    . ARG A 1 109 ? 305.835 202.651 78.193  1.00 51.52 ? 109 ARG A HD2    1 
ATOM   1533 H  HD3    . ARG A 1 109 ? 305.502 203.022 76.693  1.00 51.29 ? 109 ARG A HD3    1 
ATOM   1534 H  HE     . ARG A 1 109 ? 306.684 200.994 76.191  1.00 55.78 ? 109 ARG A HE     1 
ATOM   1535 H  HH11   . ARG A 1 109 ? 305.053 201.141 79.092  1.00 55.41 ? 109 ARG A HH11   1 
ATOM   1536 H  HH12   . ARG A 1 109 ? 304.928 199.671 79.244  1.00 55.63 ? 109 ARG A HH12   1 
ATOM   1537 H  HH21   . ARG A 1 109 ? 306.432 198.790 76.464  1.00 54.70 ? 109 ARG A HH21   1 
ATOM   1538 H  HH22   . ARG A 1 109 ? 305.750 198.257 77.675  1.00 55.83 ? 109 ARG A HH22   1 
ATOM   1539 N  N      . MET A 1 110 ? 310.090 204.334 79.669  1.00 41.04 ? 110 MET A N      1 
ATOM   1540 C  CA     . MET A 1 110 ? 309.955 205.498 80.526  1.00 40.49 ? 110 MET A CA     1 
ATOM   1541 C  C      . MET A 1 110 ? 311.216 206.350 80.564  1.00 38.10 ? 110 MET A C      1 
ATOM   1542 O  O      . MET A 1 110 ? 311.151 207.504 80.996  1.00 39.80 ? 110 MET A O      1 
ATOM   1543 C  CB     . MET A 1 110 ? 309.559 205.048 81.933  1.00 37.69 ? 110 MET A CB     1 
ATOM   1544 C  CG     . MET A 1 110 ? 309.750 206.079 82.990  1.00 41.39 ? 110 MET A CG     1 
ATOM   1545 S  SD     . MET A 1 110 ? 308.768 205.778 84.460  1.00 51.29 ? 110 MET A SD     1 
ATOM   1546 C  CE     . MET A 1 110 ? 309.155 204.064 84.705  1.00 37.67 ? 110 MET A CE     1 
ATOM   1547 H  H      . MET A 1 110 ? 310.279 203.608 80.084  1.00 41.82 ? 110 MET A H      1 
ATOM   1548 H  HA     . MET A 1 110 ? 309.240 206.049 80.184  1.00 41.30 ? 110 MET A HA     1 
ATOM   1549 H  HB2    . MET A 1 110 ? 308.629 204.787 81.936  1.00 39.54 ? 110 MET A HB2    1 
ATOM   1550 H  HB3    . MET A 1 110 ? 310.100 204.288 82.173  1.00 38.89 ? 110 MET A HB3    1 
ATOM   1551 H  HG2    . MET A 1 110 ? 310.675 206.062 83.244  1.00 41.50 ? 110 MET A HG2    1 
ATOM   1552 H  HG3    . MET A 1 110 ? 309.510 206.941 82.631  1.00 42.60 ? 110 MET A HG3    1 
ATOM   1553 H  HE1    . MET A 1 110 ? 308.855 203.566 83.932  1.00 36.78 ? 110 MET A HE1    1 
ATOM   1554 H  HE2    . MET A 1 110 ? 308.697 203.759 85.498  1.00 37.13 ? 110 MET A HE2    1 
ATOM   1555 H  HE3    . MET A 1 110 ? 310.113 203.964 84.812  1.00 37.24 ? 110 MET A HE3    1 
ATOM   1556 N  N      . LEU A 1 111 ? 312.349 205.821 80.112  1.00 37.22 ? 111 LEU A N      1 
ATOM   1557 C  CA     . LEU A 1 111 ? 313.551 206.621 79.936  1.00 37.61 ? 111 LEU A CA     1 
ATOM   1558 C  C      . LEU A 1 111 ? 313.503 207.508 78.704  1.00 41.58 ? 111 LEU A C      1 
ATOM   1559 O  O      . LEU A 1 111 ? 314.301 208.445 78.611  1.00 42.58 ? 111 LEU A O      1 
ATOM   1560 C  CB     . LEU A 1 111 ? 314.781 205.723 79.828  1.00 36.65 ? 111 LEU A CB     1 
ATOM   1561 C  CG     . LEU A 1 111 ? 315.306 204.962 81.034  1.00 32.94 ? 111 LEU A CG     1 
ATOM   1562 C  CD1    . LEU A 1 111 ? 316.217 203.884 80.575  1.00 33.73 ? 111 LEU A CD1    1 
ATOM   1563 C  CD2    . LEU A 1 111 ? 316.059 205.866 81.926  1.00 34.20 ? 111 LEU A CD2    1 
ATOM   1564 H  H      . LEU A 1 111 ? 312.442 204.999 79.893  1.00 39.02 ? 111 LEU A H      1 
ATOM   1565 H  HA     . LEU A 1 111 ? 313.662 207.195 80.704  1.00 37.73 ? 111 LEU A HA     1 
ATOM   1566 H  HB2    . LEU A 1 111 ? 314.585 205.056 79.158  1.00 39.00 ? 111 LEU A HB2    1 
ATOM   1567 H  HB3    . LEU A 1 111 ? 315.511 206.274 79.517  1.00 37.55 ? 111 LEU A HB3    1 
ATOM   1568 H  HG     . LEU A 1 111 ? 314.575 204.570 81.524  1.00 36.55 ? 111 LEU A HG     1 
ATOM   1569 H  HD11   . LEU A 1 111 ? 315.707 203.227 80.085  1.00 38.56 ? 111 LEU A HD11   1 
ATOM   1570 H  HD12   . LEU A 1 111 ? 316.630 203.484 81.351  1.00 36.19 ? 111 LEU A HD12   1 
ATOM   1571 H  HD13   . LEU A 1 111 ? 316.891 204.278 80.005  1.00 35.29 ? 111 LEU A HD13   1 
ATOM   1572 H  HD21   . LEU A 1 111 ? 316.486 205.328 82.605  1.00 35.36 ? 111 LEU A HD21   1 
ATOM   1573 H  HD22   . LEU A 1 111 ? 315.446 206.495 82.327  1.00 36.14 ? 111 LEU A HD22   1 
ATOM   1574 H  HD23   . LEU A 1 111 ? 316.724 206.329 81.398  1.00 35.03 ? 111 LEU A HD23   1 
ATOM   1575 N  N      . ASN A 1 112 ? 312.609 207.230 77.759  1.00 44.54 ? 112 ASN A N      1 
ATOM   1576 C  CA     . ASN A 1 112 ? 312.512 207.995 76.527  1.00 43.04 ? 112 ASN A CA     1 
ATOM   1577 C  C      . ASN A 1 112 ? 311.509 209.135 76.627  1.00 45.73 ? 112 ASN A C      1 
ATOM   1578 O  O      . ASN A 1 112 ? 311.390 209.925 75.688  1.00 48.28 ? 112 ASN A O      1 
ATOM   1579 C  CB     . ASN A 1 112 ? 312.136 207.081 75.364  1.00 39.44 ? 112 ASN A CB     1 
ATOM   1580 C  CG     . ASN A 1 112 ? 313.192 206.042 75.073  1.00 45.48 ? 112 ASN A CG     1 
ATOM   1581 O  OD1    . ASN A 1 112 ? 314.375 206.247 75.341  1.00 45.79 ? 112 ASN A OD1    1 
ATOM   1582 N  ND2    . ASN A 1 112 ? 312.771 204.920 74.510  1.00 46.21 ? 112 ASN A ND2    1 
ATOM   1583 H  H      . ASN A 1 112 ? 312.032 206.595 77.813  1.00 42.90 ? 112 ASN A H      1 
ATOM   1584 H  HA     . ASN A 1 112 ? 313.378 208.375 76.334  1.00 43.09 ? 112 ASN A HA     1 
ATOM   1585 H  HB2    . ASN A 1 112 ? 311.314 206.619 75.577  1.00 41.17 ? 112 ASN A HB2    1 
ATOM   1586 H  HB3    . ASN A 1 112 ? 312.020 207.620 74.572  1.00 42.28 ? 112 ASN A HB3    1 
ATOM   1587 H  HD21   . ASN A 1 112 ? 311.937 204.817 74.335  1.00 44.24 ? 112 ASN A HD21   1 
ATOM   1588 H  HD22   . ASN A 1 112 ? 313.330 204.295 74.322  1.00 45.82 ? 112 ASN A HD22   1 
ATOM   1589 N  N      . GLU A 1 113 ? 310.775 209.227 77.727  1.00 43.20 ? 113 GLU A N      1 
ATOM   1590 C  CA     . GLU A 1 113 ? 309.838 210.315 77.933  1.00 44.20 ? 113 GLU A CA     1 
ATOM   1591 C  C      . GLU A 1 113 ? 310.591 211.604 78.231  1.00 46.34 ? 113 GLU A C      1 
ATOM   1592 O  O      . GLU A 1 113 ? 311.618 211.608 78.912  1.00 49.45 ? 113 GLU A O      1 
ATOM   1593 C  CB     . GLU A 1 113 ? 308.876 209.996 79.072  1.00 45.86 ? 113 GLU A CB     1 
ATOM   1594 C  CG     . GLU A 1 113 ? 308.195 208.644 78.977  1.00 47.89 ? 113 GLU A CG     1 
ATOM   1595 C  CD     . GLU A 1 113 ? 307.132 208.591 77.903  1.00 58.08 ? 113 GLU A CD     1 
ATOM   1596 O  OE1    . GLU A 1 113 ? 307.283 207.798 76.951  1.00 57.51 ? 113 GLU A OE1    1 
ATOM   1597 O  OE2    . GLU A 1 113 ? 306.140 209.343 78.013  1.00 58.76 ? 113 GLU A OE2    1 
ATOM   1598 H  H      . GLU A 1 113 ? 310.801 208.664 78.372  1.00 44.15 ? 113 GLU A H      1 
ATOM   1599 H  HA     . GLU A 1 113 ? 309.323 210.449 77.131  1.00 46.86 ? 113 GLU A HA     1 
ATOM   1600 H  HB2    . GLU A 1 113 ? 309.367 210.029 79.906  1.00 45.36 ? 113 GLU A HB2    1 
ATOM   1601 H  HB3    . GLU A 1 113 ? 308.182 210.666 79.080  1.00 47.17 ? 113 GLU A HB3    1 
ATOM   1602 H  HG2    . GLU A 1 113 ? 308.852 207.966 78.772  1.00 46.32 ? 113 GLU A HG2    1 
ATOM   1603 H  HG3    . GLU A 1 113 ? 307.767 208.452 79.823  1.00 46.23 ? 113 GLU A HG3    1 
ATOM   1604 N  N      . ASP A 1 114 ? 310.067 212.708 77.701  1.00 51.83 ? 114 ASP A N      1 
ATOM   1605 C  CA     . ASP A 1 114 ? 310.729 213.998 77.795  1.00 52.82 ? 114 ASP A CA     1 
ATOM   1606 C  C      . ASP A 1 114 ? 310.428 214.738 79.090  1.00 54.57 ? 114 ASP A C      1 
ATOM   1607 O  O      . ASP A 1 114 ? 311.150 215.681 79.426  1.00 59.68 ? 114 ASP A O      1 
ATOM   1608 C  CB     . ASP A 1 114 ? 310.324 214.878 76.612  1.00 56.82 ? 114 ASP A CB     1 
ATOM   1609 C  CG     . ASP A 1 114 ? 310.733 214.288 75.275  1.00 64.91 ? 114 ASP A CG     1 
ATOM   1610 O  OD1    . ASP A 1 114 ? 311.864 213.768 75.166  1.00 67.48 ? 114 ASP A OD1    1 
ATOM   1611 O  OD2    . ASP A 1 114 ? 309.920 214.350 74.329  1.00 66.81 ? 114 ASP A OD2    1 
ATOM   1612 H  H      . ASP A 1 114 ? 309.323 212.735 77.278  1.00 52.71 ? 114 ASP A H      1 
ATOM   1613 H  HA     . ASP A 1 114 ? 311.685 213.858 77.753  1.00 53.47 ? 114 ASP A HA     1 
ATOM   1614 H  HB2    . ASP A 1 114 ? 309.359 214.962 76.612  1.00 56.38 ? 114 ASP A HB2    1 
ATOM   1615 H  HB3    . ASP A 1 114 ? 310.743 215.744 76.706  1.00 57.60 ? 114 ASP A HB3    1 
ATOM   1616 N  N      . GLU A 1 115 ? 309.384 214.344 79.818  1.00 51.30 ? 115 GLU A N      1 
ATOM   1617 C  CA     . GLU A 1 115 ? 309.108 214.960 81.109  1.00 50.27 ? 115 GLU A CA     1 
ATOM   1618 C  C      . GLU A 1 115 ? 310.083 214.480 82.175  1.00 52.59 ? 115 GLU A C      1 
ATOM   1619 O  O      . GLU A 1 115 ? 310.334 215.190 83.156  1.00 53.31 ? 115 GLU A O      1 
ATOM   1620 C  CB     . GLU A 1 115 ? 307.672 214.664 81.526  1.00 49.18 ? 115 GLU A CB     1 
ATOM   1621 C  CG     . GLU A 1 115 ? 306.631 215.154 80.542  1.00 54.94 ? 115 GLU A CG     1 
ATOM   1622 C  CD     . GLU A 1 115 ? 305.374 214.307 80.536  1.00 65.29 ? 115 GLU A CD     1 
ATOM   1623 O  OE1    . GLU A 1 115 ? 304.420 214.654 81.262  1.00 68.72 ? 115 GLU A OE1    1 
ATOM   1624 O  OE2    . GLU A 1 115 ? 305.339 213.298 79.801  1.00 62.67 ? 115 GLU A OE2    1 
ATOM   1625 H  H      . GLU A 1 115 ? 308.825 213.735 79.590  1.00 52.49 ? 115 GLU A H      1 
ATOM   1626 H  HA     . GLU A 1 115 ? 309.201 215.918 81.028  1.00 52.72 ? 115 GLU A HA     1 
ATOM   1627 H  HB2    . GLU A 1 115 ? 307.565 213.708 81.615  1.00 51.08 ? 115 GLU A HB2    1 
ATOM   1628 H  HB3    . GLU A 1 115 ? 307.514 215.106 82.371  1.00 51.66 ? 115 GLU A HB3    1 
ATOM   1629 H  HG2    . GLU A 1 115 ? 306.375 216.055 80.785  1.00 57.01 ? 115 GLU A HG2    1 
ATOM   1630 H  HG3    . GLU A 1 115 ? 307.008 215.135 79.650  1.00 54.96 ? 115 GLU A HG3    1 
ATOM   1631 N  N      . LEU A 1 116 ? 310.648 213.288 81.996  1.00 48.85 ? 116 LEU A N      1 
ATOM   1632 C  CA     . LEU A 1 116 ? 311.624 212.734 82.933  1.00 45.53 ? 116 LEU A CA     1 
ATOM   1633 C  C      . LEU A 1 116 ? 313.048 212.910 82.405  1.00 46.51 ? 116 LEU A C      1 
ATOM   1634 O  O      . LEU A 1 116 ? 313.942 212.107 82.657  1.00 50.03 ? 116 LEU A O      1 
ATOM   1635 C  CB     . LEU A 1 116 ? 311.330 211.264 83.192  1.00 43.06 ? 116 LEU A CB     1 
ATOM   1636 C  CG     . LEU A 1 116 ? 310.001 210.855 83.795  1.00 41.62 ? 116 LEU A CG     1 
ATOM   1637 C  CD1    . LEU A 1 116 ? 310.005 209.379 83.966  1.00 40.00 ? 116 LEU A CD1    1 
ATOM   1638 C  CD2    . LEU A 1 116 ? 309.799 211.522 85.110  1.00 44.45 ? 116 LEU A CD2    1 
ATOM   1639 H  H      . LEU A 1 116 ? 310.479 212.775 81.333  1.00 49.33 ? 116 LEU A H      1 
ATOM   1640 H  HA     . LEU A 1 116 ? 311.555 213.204 83.773  1.00 46.66 ? 116 LEU A HA     1 
ATOM   1641 H  HB2    . LEU A 1 116 ? 311.396 210.805 82.346  1.00 44.33 ? 116 LEU A HB2    1 
ATOM   1642 H  HB3    . LEU A 1 116 ? 312.009 210.926 83.786  1.00 45.10 ? 116 LEU A HB3    1 
ATOM   1643 H  HG     . LEU A 1 116 ? 309.281 211.096 83.199  1.00 43.58 ? 116 LEU A HG     1 
ATOM   1644 H  HD11   . LEU A 1 116 ? 310.142 208.972 83.099  1.00 41.53 ? 116 LEU A HD11   1 
ATOM   1645 H  HD12   . LEU A 1 116 ? 309.159 209.104 84.343  1.00 41.04 ? 116 LEU A HD12   1 
ATOM   1646 H  HD13   . LEU A 1 116 ? 310.727 209.146 84.562  1.00 40.61 ? 116 LEU A HD13   1 
ATOM   1647 H  HD21   . LEU A 1 116 ? 310.581 211.364 85.656  1.00 43.33 ? 116 LEU A HD21   1 
ATOM   1648 H  HD22   . LEU A 1 116 ? 309.015 211.146 85.534  1.00 44.25 ? 116 LEU A HD22   1 
ATOM   1649 H  HD23   . LEU A 1 116 ? 309.680 212.470 84.959  1.00 45.17 ? 116 LEU A HD23   1 
ATOM   1650 N  N      . ARG A 1 117 ? 313.250 213.988 81.655  1.00 44.21 ? 117 ARG A N      1 
ATOM   1651 C  CA     . ARG A 1 117 ? 314.493 214.191 80.925  1.00 52.94 ? 117 ARG A CA     1 
ATOM   1652 C  C      . ARG A 1 117 ? 315.697 214.417 81.821  1.00 54.64 ? 117 ARG A C      1 
ATOM   1653 O  O      . ARG A 1 117 ? 316.799 213.990 81.469  1.00 54.66 ? 117 ARG A O      1 
ATOM   1654 C  CB     . ARG A 1 117 ? 314.361 215.382 79.973  1.00 60.20 ? 117 ARG A CB     1 
ATOM   1655 C  CG     . ARG A 1 117 ? 315.468 215.476 78.938  1.00 60.72 ? 117 ARG A CG     1 
ATOM   1656 C  CD     . ARG A 1 117 ? 315.308 216.688 78.029  1.00 63.90 ? 117 ARG A CD     1 
ATOM   1657 N  NE     . ARG A 1 117 ? 314.667 217.810 78.706  1.00 66.08 ? 117 ARG A NE     1 
ATOM   1658 C  CZ     . ARG A 1 117 ? 313.384 218.130 78.598  1.00 69.80 ? 117 ARG A CZ     1 
ATOM   1659 N  NH1    . ARG A 1 117 ? 312.565 217.461 77.805  1.00 67.89 ? 117 ARG A NH1    1 
ATOM   1660 N  NH2    . ARG A 1 117 ? 312.909 219.147 79.311  1.00 67.82 ? 117 ARG A NH2    1 
ATOM   1661 H  H      . ARG A 1 117 ? 312.681 214.619 81.557  1.00 49.49 ? 117 ARG A H      1 
ATOM   1662 H  HA     . ARG A 1 117 ? 314.669 213.405 80.392  1.00 52.76 ? 117 ARG A HA     1 
ATOM   1663 H  HB2    . ARG A 1 117 ? 313.526 215.304 79.491  1.00 58.26 ? 117 ARG A HB2    1 
ATOM   1664 H  HB3    . ARG A 1 117 ? 314.367 216.191 80.503  1.00 58.98 ? 117 ARG A HB3    1 
ATOM   1665 H  HG2    . ARG A 1 117 ? 316.324 215.542 79.384  1.00 59.66 ? 117 ARG A HG2    1 
ATOM   1666 H  HG3    . ARG A 1 117 ? 315.440 214.682 78.381  1.00 59.41 ? 117 ARG A HG3    1 
ATOM   1667 H  HD2    . ARG A 1 117 ? 316.186 216.982 77.746  1.00 63.41 ? 117 ARG A HD2    1 
ATOM   1668 H  HD3    . ARG A 1 117 ? 314.784 216.435 77.256  1.00 63.45 ? 117 ARG A HD3    1 
ATOM   1669 H  HE     . ARG A 1 117 ? 315.136 218.251 79.273  1.00 64.44 ? 117 ARG A HE     1 
ATOM   1670 H  HH11   . ARG A 1 117 ? 312.853 216.802 77.335  1.00 64.27 ? 117 ARG A HH11   1 
ATOM   1671 H  HH12   . ARG A 1 117 ? 311.739 217.689 77.755  1.00 65.29 ? 117 ARG A HH12   1 
ATOM   1672 H  HH21   . ARG A 1 117 ? 313.432 219.589 79.830  1.00 66.80 ? 117 ARG A HH21   1 
ATOM   1673 H  HH22   . ARG A 1 117 ? 312.080 219.364 79.251  1.00 67.15 ? 117 ARG A HH22   1 
ATOM   1674 N  N      . ASN A 1 118 ? 315.514 215.062 82.969  1.00 48.17 ? 118 ASN A N      1 
ATOM   1675 C  CA     . ASN A 1 118 ? 316.606 215.359 83.886  1.00 48.54 ? 118 ASN A CA     1 
ATOM   1676 C  C      . ASN A 1 118 ? 316.556 214.498 85.140  1.00 45.64 ? 118 ASN A C      1 
ATOM   1677 O  O      . ASN A 1 118 ? 317.460 214.580 85.978  1.00 43.52 ? 118 ASN A O      1 
ATOM   1678 C  CB     . ASN A 1 118 ? 316.574 216.837 84.267  1.00 52.03 ? 118 ASN A CB     1 
ATOM   1679 C  CG     . ASN A 1 118 ? 316.475 217.746 83.064  1.00 58.30 ? 118 ASN A CG     1 
ATOM   1680 O  OD1    . ASN A 1 118 ? 317.277 217.658 82.135  1.00 61.89 ? 118 ASN A OD1    1 
ATOM   1681 N  ND2    . ASN A 1 118 ? 315.479 218.622 83.068  1.00 56.98 ? 118 ASN A ND2    1 
ATOM   1682 H  H      . ASN A 1 118 ? 314.751 215.341 83.244  1.00 49.65 ? 118 ASN A H      1 
ATOM   1683 H  HA     . ASN A 1 118 ? 317.446 215.183 83.439  1.00 50.82 ? 118 ASN A HA     1 
ATOM   1684 H  HB2    . ASN A 1 118 ? 315.796 216.995 84.824  1.00 51.51 ? 118 ASN A HB2    1 
ATOM   1685 H  HB3    . ASN A 1 118 ? 317.386 217.059 84.748  1.00 52.70 ? 118 ASN A HB3    1 
ATOM   1686 H  HD21   . ASN A 1 118 ? 314.937 218.651 83.736  1.00 55.22 ? 118 ASN A HD21   1 
ATOM   1687 H  HD22   . ASN A 1 118 ? 315.374 219.160 82.407  1.00 58.58 ? 118 ASN A HD22   1 
ATOM   1688 N  N      . ALA A 1 119 ? 315.523 213.676 85.286  1.00 44.15 ? 119 ALA A N      1 
ATOM   1689 C  CA     . ALA A 1 119 ? 315.339 212.888 86.489  1.00 39.65 ? 119 ALA A CA     1 
ATOM   1690 C  C      . ALA A 1 119 ? 316.528 211.971 86.740  1.00 39.17 ? 119 ALA A C      1 
ATOM   1691 O  O      . ALA A 1 119 ? 317.111 211.389 85.823  1.00 38.30 ? 119 ALA A O      1 
ATOM   1692 C  CB     . ALA A 1 119 ? 314.070 212.057 86.386  1.00 37.27 ? 119 ALA A CB     1 
ATOM   1693 H  H      . ALA A 1 119 ? 314.910 213.557 84.701  1.00 45.42 ? 119 ALA A H      1 
ATOM   1694 H  HA     . ALA A 1 119 ? 315.253 213.485 87.242  1.00 40.06 ? 119 ALA A HA     1 
ATOM   1695 H  HB1    . ALA A 1 119 ? 313.317 212.650 86.268  1.00 40.25 ? 119 ALA A HB1    1 
ATOM   1696 H  HB2    . ALA A 1 119 ? 313.967 211.550 87.200  1.00 36.95 ? 119 ALA A HB2    1 
ATOM   1697 H  HB3    . ALA A 1 119 ? 314.156 211.463 85.630  1.00 39.73 ? 119 ALA A HB3    1 
ATOM   1698 N  N      . ALA A 1 120 ? 316.894 211.863 88.010  1.00 37.21 ? 120 ALA A N      1 
ATOM   1699 C  CA     . ALA A 1 120 ? 317.888 210.908 88.474  1.00 30.53 ? 120 ALA A CA     1 
ATOM   1700 C  C      . ALA A 1 120 ? 317.251 209.535 88.565  1.00 31.47 ? 120 ALA A C      1 
ATOM   1701 O  O      . ALA A 1 120 ? 316.071 209.415 88.905  1.00 39.96 ? 120 ALA A O      1 
ATOM   1702 C  CB     . ALA A 1 120 ? 318.452 211.319 89.827  1.00 30.13 ? 120 ALA A CB     1 
ATOM   1703 H  H      . ALA A 1 120 ? 316.588 212.364 88.630  1.00 37.14 ? 120 ALA A H      1 
ATOM   1704 H  HA     . ALA A 1 120 ? 318.622 210.859 87.853  1.00 32.83 ? 120 ALA A HA     1 
ATOM   1705 H  HB1    . ALA A 1 120 ? 317.720 211.364 90.460  1.00 32.07 ? 120 ALA A HB1    1 
ATOM   1706 H  HB2    . ALA A 1 120 ? 318.890 212.180 89.740  1.00 32.24 ? 120 ALA A HB2    1 
ATOM   1707 H  HB3    . ALA A 1 120 ? 319.090 210.646 90.106  1.00 31.38 ? 120 ALA A HB3    1 
ATOM   1708 N  N      . TRP A 1 121 ? 318.036 208.510 88.278  1.00 28.84 ? 121 TRP A N      1 
ATOM   1709 C  CA     . TRP A 1 121 ? 317.561 207.140 88.224  1.00 27.74 ? 121 TRP A CA     1 
ATOM   1710 C  C      . TRP A 1 121 ? 318.195 206.351 89.356  1.00 27.82 ? 121 TRP A C      1 
ATOM   1711 O  O      . TRP A 1 121 ? 319.420 206.300 89.475  1.00 32.34 ? 121 TRP A O      1 
ATOM   1712 C  CB     . TRP A 1 121 ? 317.898 206.514 86.878  1.00 27.15 ? 121 TRP A CB     1 
ATOM   1713 C  CG     . TRP A 1 121 ? 316.856 205.605 86.385  1.00 29.56 ? 121 TRP A CG     1 
ATOM   1714 C  CD1    . TRP A 1 121 ? 316.850 204.249 86.450  1.00 31.67 ? 121 TRP A CD1    1 
ATOM   1715 C  CD2    . TRP A 1 121 ? 315.640 205.983 85.758  1.00 32.52 ? 121 TRP A CD2    1 
ATOM   1716 N  NE1    . TRP A 1 121 ? 315.700 203.755 85.895  1.00 34.90 ? 121 TRP A NE1    1 
ATOM   1717 C  CE2    . TRP A 1 121 ? 314.938 204.807 85.463  1.00 33.59 ? 121 TRP A CE2    1 
ATOM   1718 C  CE3    . TRP A 1 121 ? 315.074 207.207 85.416  1.00 32.74 ? 121 TRP A CE3    1 
ATOM   1719 C  CZ2    . TRP A 1 121 ? 313.705 204.822 84.843  1.00 31.24 ? 121 TRP A CZ2    1 
ATOM   1720 C  CZ3    . TRP A 1 121 ? 313.861 207.218 84.802  1.00 32.11 ? 121 TRP A CZ3    1 
ATOM   1721 C  CH2    . TRP A 1 121 ? 313.184 206.040 84.522  1.00 32.77 ? 121 TRP A CH2    1 
ATOM   1722 H  H      . TRP A 1 121 ? 318.869 208.585 88.106  1.00 30.60 ? 121 TRP A H      1 
ATOM   1723 H  HA     . TRP A 1 121 ? 316.603 207.130 88.338  1.00 30.16 ? 121 TRP A HA     1 
ATOM   1724 H  HB2    . TRP A 1 121 ? 317.997 207.229 86.238  1.00 28.98 ? 121 TRP A HB2    1 
ATOM   1725 H  HB3    . TRP A 1 121 ? 318.720 206.011 86.958  1.00 29.35 ? 121 TRP A HB3    1 
ATOM   1726 H  HD1    . TRP A 1 121 ? 317.527 203.733 86.816  1.00 31.62 ? 121 TRP A HD1    1 
ATOM   1727 H  HE1    . TRP A 1 121 ? 315.492 202.925 85.831  1.00 34.75 ? 121 TRP A HE1    1 
ATOM   1728 H  HE3    . TRP A 1 121 ? 315.517 207.999 85.599  1.00 32.56 ? 121 TRP A HE3    1 
ATOM   1729 H  HZ2    . TRP A 1 121 ? 313.250 204.038 84.652  1.00 33.58 ? 121 TRP A HZ2    1 
ATOM   1730 H  HZ3    . TRP A 1 121 ? 313.479 208.027 84.571  1.00 33.68 ? 121 TRP A HZ3    1 
ATOM   1731 H  HH2    . TRP A 1 121 ? 312.363 206.084 84.107  1.00 35.10 ? 121 TRP A HH2    1 
ATOM   1732 N  N      . LEU A 1 122 ? 317.359 205.723 90.168  1.00 25.26 ? 122 LEU A N      1 
ATOM   1733 C  CA     . LEU A 1 122 ? 317.808 204.792 91.182  1.00 25.43 ? 122 LEU A CA     1 
ATOM   1734 C  C      . LEU A 1 122 ? 317.037 203.499 91.012  1.00 26.15 ? 122 LEU A C      1 
ATOM   1735 O  O      . LEU A 1 122 ? 315.865 203.511 90.634  1.00 30.29 ? 122 LEU A O      1 
ATOM   1736 C  CB     . LEU A 1 122 ? 317.586 205.362 92.575  1.00 26.93 ? 122 LEU A CB     1 
ATOM   1737 C  CG     . LEU A 1 122 ? 317.905 204.495 93.779  1.00 25.56 ? 122 LEU A CG     1 
ATOM   1738 C  CD1    . LEU A 1 122 ? 319.369 204.339 93.991  1.00 27.16 ? 122 LEU A CD1    1 
ATOM   1739 C  CD2    . LEU A 1 122 ? 317.289 205.133 94.968  1.00 24.88 ? 122 LEU A CD2    1 
ATOM   1740 H  H      . LEU A 1 122 ? 316.511 205.817 90.146  1.00 27.45 ? 122 LEU A H      1 
ATOM   1741 H  HA     . LEU A 1 122 ? 318.745 204.609 91.064  1.00 26.49 ? 122 LEU A HA     1 
ATOM   1742 H  HB2    . LEU A 1 122 ? 318.109 206.170 92.661  1.00 27.07 ? 122 LEU A HB2    1 
ATOM   1743 H  HB3    . LEU A 1 122 ? 316.647 205.570 92.640  1.00 26.72 ? 122 LEU A HB3    1 
ATOM   1744 H  HG     . LEU A 1 122 ? 317.520 203.622 93.663  1.00 25.89 ? 122 LEU A HG     1 
ATOM   1745 H  HD11   . LEU A 1 122 ? 319.735 205.202 94.221  1.00 27.37 ? 122 LEU A HD11   1 
ATOM   1746 H  HD12   . LEU A 1 122 ? 319.768 204.009 93.178  1.00 26.64 ? 122 LEU A HD12   1 
ATOM   1747 H  HD13   . LEU A 1 122 ? 319.511 203.713 94.713  1.00 25.74 ? 122 LEU A HD13   1 
ATOM   1748 H  HD21   . LEU A 1 122 ? 317.603 206.044 95.021  1.00 23.54 ? 122 LEU A HD21   1 
ATOM   1749 H  HD22   . LEU A 1 122 ? 317.557 204.640 95.752  1.00 25.60 ? 122 LEU A HD22   1 
ATOM   1750 H  HD23   . LEU A 1 122 ? 316.328 205.117 94.863  1.00 25.69 ? 122 LEU A HD23   1 
ATOM   1751 N  N      . VAL A 1 123 ? 317.705 202.384 91.267  1.00 25.47 ? 123 VAL A N      1 
ATOM   1752 C  CA     . VAL A 1 123 ? 317.126 201.072 91.055  1.00 24.84 ? 123 VAL A CA     1 
ATOM   1753 C  C      . VAL A 1 123 ? 317.283 200.280 92.339  1.00 26.33 ? 123 VAL A C      1 
ATOM   1754 O  O      . VAL A 1 123 ? 318.406 200.021 92.779  1.00 28.60 ? 123 VAL A O      1 
ATOM   1755 C  CB     . VAL A 1 123 ? 317.786 200.343 89.880  1.00 23.82 ? 123 VAL A CB     1 
ATOM   1756 C  CG1    . VAL A 1 123 ? 317.013 199.124 89.521  1.00 26.59 ? 123 VAL A CG1    1 
ATOM   1757 C  CG2    . VAL A 1 123 ? 317.862 201.244 88.701  1.00 25.64 ? 123 VAL A CG2    1 
ATOM   1758 H  H      . VAL A 1 123 ? 318.506 202.354 91.565  1.00 26.25 ? 123 VAL A H      1 
ATOM   1759 H  HA     . VAL A 1 123 ? 316.186 201.166 90.870  1.00 26.39 ? 123 VAL A HA     1 
ATOM   1760 H  HB     . VAL A 1 123 ? 318.677 200.084 90.133  1.00 24.90 ? 123 VAL A HB     1 
ATOM   1761 H  HG11   . VAL A 1 123 ? 316.186 199.399 89.103  1.00 28.10 ? 123 VAL A HG11   1 
ATOM   1762 H  HG12   . VAL A 1 123 ? 316.833 198.624 90.323  1.00 27.26 ? 123 VAL A HG12   1 
ATOM   1763 H  HG13   . VAL A 1 123 ? 317.539 198.593 88.909  1.00 25.29 ? 123 VAL A HG13   1 
ATOM   1764 H  HG21   . VAL A 1 123 ? 318.590 201.867 88.821  1.00 26.56 ? 123 VAL A HG21   1 
ATOM   1765 H  HG22   . VAL A 1 123 ? 317.024 201.718 88.631  1.00 27.04 ? 123 VAL A HG22   1 
ATOM   1766 H  HG23   . VAL A 1 123 ? 318.001 200.708 87.912  1.00 26.68 ? 123 VAL A HG23   1 
ATOM   1767 N  N      . PHE A 1 124 ? 316.163 199.907 92.936  1.00 25.61 ? 124 PHE A N      1 
ATOM   1768 C  CA     . PHE A 1 124 ? 316.142 199.060 94.118  1.00 24.94 ? 124 PHE A CA     1 
ATOM   1769 C  C      . PHE A 1 124 ? 315.912 197.632 93.650  1.00 29.09 ? 124 PHE A C      1 
ATOM   1770 O  O      . PHE A 1 124 ? 314.799 197.257 93.276  1.00 38.15 ? 124 PHE A O      1 
ATOM   1771 C  CB     . PHE A 1 124 ? 315.061 199.495 95.099  1.00 26.71 ? 124 PHE A CB     1 
ATOM   1772 C  CG     . PHE A 1 124 ? 315.457 200.618 96.019  1.00 27.04 ? 124 PHE A CG     1 
ATOM   1773 C  CD1    . PHE A 1 124 ? 316.770 200.977 96.204  1.00 26.35 ? 124 PHE A CD1    1 
ATOM   1774 C  CD2    . PHE A 1 124 ? 314.492 201.303 96.721  1.00 27.80 ? 124 PHE A CD2    1 
ATOM   1775 C  CE1    . PHE A 1 124 ? 317.104 201.997 97.054  1.00 27.62 ? 124 PHE A CE1    1 
ATOM   1776 C  CE2    . PHE A 1 124 ? 314.828 202.321 97.571  1.00 23.16 ? 124 PHE A CE2    1 
ATOM   1777 C  CZ     . PHE A 1 124 ? 316.131 202.667 97.736  1.00 24.16 ? 124 PHE A CZ     1 
ATOM   1778 H  H      . PHE A 1 124 ? 315.384 200.125 92.666  1.00 27.32 ? 124 PHE A H      1 
ATOM   1779 H  HA     . PHE A 1 124 ? 317.008 199.078 94.536  1.00 26.06 ? 124 PHE A HA     1 
ATOM   1780 H  HB2    . PHE A 1 124 ? 314.295 199.792 94.593  1.00 27.49 ? 124 PHE A HB2    1 
ATOM   1781 H  HB3    . PHE A 1 124 ? 314.826 198.736 95.647  1.00 27.09 ? 124 PHE A HB3    1 
ATOM   1782 H  HD1    . PHE A 1 124 ? 317.438 200.531 95.748  1.00 26.55 ? 124 PHE A HD1    1 
ATOM   1783 H  HD2    . PHE A 1 124 ? 313.602 201.071 96.611  1.00 27.44 ? 124 PHE A HD2    1 
ATOM   1784 H  HE1    . PHE A 1 124 ? 317.992 202.231 97.167  1.00 27.70 ? 124 PHE A HE1    1 
ATOM   1785 H  HE2    . PHE A 1 124 ? 314.170 202.778 98.035  1.00 24.91 ? 124 PHE A HE2    1 
ATOM   1786 H  HZ     . PHE A 1 124 ? 316.355 203.357 98.312  1.00 23.96 ? 124 PHE A HZ     1 
ATOM   1787 N  N      . ALA A 1 125 ? 316.971 196.841 93.673  1.00 26.77 ? 125 ALA A N      1 
ATOM   1788 C  CA     . ALA A 1 125 ? 316.882 195.410 93.424  1.00 28.89 ? 125 ALA A CA     1 
ATOM   1789 C  C      . ALA A 1 125 ? 316.470 194.749 94.728  1.00 31.56 ? 125 ALA A C      1 
ATOM   1790 O  O      . ALA A 1 125 ? 317.303 194.383 95.555  1.00 37.55 ? 125 ALA A O      1 
ATOM   1791 C  CB     . ALA A 1 125 ? 318.208 194.879 92.916  1.00 32.69 ? 125 ALA A CB     1 
ATOM   1792 H  H      . ALA A 1 125 ? 317.767 197.110 93.820  1.00 27.82 ? 125 ALA A H      1 
ATOM   1793 H  HA     . ALA A 1 125 ? 316.205 195.239 92.760  1.00 30.67 ? 125 ALA A HA     1 
ATOM   1794 H  HB1    . ALA A 1 125 ? 318.876 195.038 93.594  1.00 32.76 ? 125 ALA A HB1    1 
ATOM   1795 H  HB2    . ALA A 1 125 ? 318.431 195.355 92.106  1.00 31.71 ? 125 ALA A HB2    1 
ATOM   1796 H  HB3    . ALA A 1 125 ? 318.122 193.936 92.743  1.00 32.93 ? 125 ALA A HB3    1 
ATOM   1797 N  N      . ASN A 1 126 ? 315.169 194.592 94.917  1.00 31.65 ? 126 ASN A N      1 
ATOM   1798 C  CA     . ASN A 1 126 ? 314.632 194.193 96.203  1.00 33.20 ? 126 ASN A CA     1 
ATOM   1799 C  C      . ASN A 1 126 ? 314.508 192.678 96.293  1.00 35.66 ? 126 ASN A C      1 
ATOM   1800 O  O      . ASN A 1 126 ? 314.687 191.953 95.314  1.00 40.26 ? 126 ASN A O      1 
ATOM   1801 C  CB     . ASN A 1 126 ? 313.280 194.854 96.436  1.00 30.78 ? 126 ASN A CB     1 
ATOM   1802 C  CG     . ASN A 1 126 ? 312.916 194.932 97.882  1.00 34.55 ? 126 ASN A CG     1 
ATOM   1803 O  OD1    . ASN A 1 126 ? 313.753 194.749 98.759  1.00 38.24 ? 126 ASN A OD1    1 
ATOM   1804 N  ND2    . ASN A 1 126 ? 311.656 195.207 98.147  1.00 33.62 ? 126 ASN A ND2    1 
ATOM   1805 H  H      . ASN A 1 126 ? 314.572 194.700 94.312  1.00 32.82 ? 126 ASN A H      1 
ATOM   1806 H  HA     . ASN A 1 126 ? 315.234 194.486 96.897  1.00 33.55 ? 126 ASN A HA     1 
ATOM   1807 H  HB2    . ASN A 1 126 ? 313.301 195.756 96.096  1.00 31.51 ? 126 ASN A HB2    1 
ATOM   1808 H  HB3    . ASN A 1 126 ? 312.598 194.339 95.990  1.00 32.32 ? 126 ASN A HB3    1 
ATOM   1809 H  HD21   . ASN A 1 126 ? 311.110 195.325 97.495  1.00 32.59 ? 126 ASN A HD21   1 
ATOM   1810 H  HD22   . ASN A 1 126 ? 311.388 195.263 98.958  1.00 34.34 ? 126 ASN A HD22   1 
ATOM   1811 N  N      . LYS A 1 127 ? 314.190 192.207 97.498  1.00 37.36 ? 127 LYS A N      1 
ATOM   1812 C  CA     . LYS A 1 127 ? 314.033 190.785 97.783  1.00 38.71 ? 127 LYS A CA     1 
ATOM   1813 C  C      . LYS A 1 127 ? 315.359 190.048 97.644  1.00 40.97 ? 127 LYS A C      1 
ATOM   1814 O  O      . LYS A 1 127 ? 315.427 188.968 97.062  1.00 43.35 ? 127 LYS A O      1 
ATOM   1815 C  CB     . LYS A 1 127 ? 312.961 190.155 96.896  1.00 35.66 ? 127 LYS A CB     1 
ATOM   1816 C  CG     . LYS A 1 127 ? 311.571 190.671 97.154  1.00 34.82 ? 127 LYS A CG     1 
ATOM   1817 C  CD     . LYS A 1 127 ? 310.668 190.377 95.999  1.00 36.21 ? 127 LYS A CD     1 
ATOM   1818 C  CE     . LYS A 1 127 ? 309.282 190.885 96.213  1.00 35.15 ? 127 LYS A CE     1 
ATOM   1819 N  NZ     . LYS A 1 127 ? 308.432 189.940 96.946  1.00 37.12 ? 127 LYS A NZ     1 
ATOM   1820 H  H      . LYS A 1 127 ? 314.061 192.708 98.181  1.00 37.14 ? 127 LYS A H      1 
ATOM   1821 H  HA     . LYS A 1 127 ? 313.746 190.688 98.700  1.00 38.29 ? 127 LYS A HA     1 
ATOM   1822 H  HB2    . LYS A 1 127 ? 313.171 190.329 95.972  1.00 37.31 ? 127 LYS A HB2    1 
ATOM   1823 H  HB3    . LYS A 1 127 ? 312.952 189.205 97.054  1.00 36.72 ? 127 LYS A HB3    1 
ATOM   1824 H  HG2    . LYS A 1 127 ? 311.205 190.244 97.940  1.00 35.96 ? 127 LYS A HG2    1 
ATOM   1825 H  HG3    . LYS A 1 127 ? 311.605 191.628 97.263  1.00 35.57 ? 127 LYS A HG3    1 
ATOM   1826 H  HD2    . LYS A 1 127 ? 311.023 190.819 95.222  1.00 37.25 ? 127 LYS A HD2    1 
ATOM   1827 H  HD3    . LYS A 1 127 ? 310.618 189.423 95.865  1.00 37.98 ? 127 LYS A HD3    1 
ATOM   1828 H  HE2    . LYS A 1 127 ? 309.333 191.703 96.721  1.00 35.39 ? 127 LYS A HE2    1 
ATOM   1829 H  HE3    . LYS A 1 127 ? 308.874 191.044 95.354  1.00 35.00 ? 127 LYS A HE3    1 
ATOM   1830 H  HZ1    . LYS A 1 127 ? 308.696 189.891 97.791  1.00 36.80 ? 127 LYS A HZ1    1 
ATOM   1831 H  HZ2    . LYS A 1 127 ? 308.485 189.135 96.577  1.00 38.07 ? 127 LYS A HZ2    1 
ATOM   1832 H  HZ3    . LYS A 1 127 ? 307.591 190.220 96.915  1.00 35.19 ? 127 LYS A HZ3    1 
ATOM   1833 N  N      . GLN A 1 128 ? 316.418 190.638 98.190  1.00 39.60 ? 128 GLN A N      1 
ATOM   1834 C  CA     . GLN A 1 128 ? 317.715 189.984 98.253  1.00 41.76 ? 128 GLN A CA     1 
ATOM   1835 C  C      . GLN A 1 128 ? 317.810 188.974 99.385  1.00 45.35 ? 128 GLN A C      1 
ATOM   1836 O  O      . GLN A 1 128 ? 318.743 188.165 99.390  1.00 50.51 ? 128 GLN A O      1 
ATOM   1837 C  CB     . GLN A 1 128 ? 318.822 191.019 98.416  1.00 42.30 ? 128 GLN A CB     1 
ATOM   1838 C  CG     . GLN A 1 128 ? 319.004 191.924 97.227  1.00 40.99 ? 128 GLN A CG     1 
ATOM   1839 C  CD     . GLN A 1 128 ? 319.988 191.379 96.229  1.00 39.64 ? 128 GLN A CD     1 
ATOM   1840 O  OE1    . GLN A 1 128 ? 321.140 191.111 96.557  1.00 43.04 ? 128 GLN A OE1    1 
ATOM   1841 N  NE2    . GLN A 1 128 ? 319.539 191.214 95.001  1.00 38.27 ? 128 GLN A NE2    1 
ATOM   1842 H  H      . GLN A 1 128 ? 316.408 191.422 98.531  1.00 39.29 ? 128 GLN A H      1 
ATOM   1843 H  HA     . GLN A 1 128 ? 317.869 189.515 97.422  1.00 41.24 ? 128 GLN A HA     1 
ATOM   1844 H  HB2    . GLN A 1 128 ? 318.610 191.574 99.177  1.00 41.85 ? 128 GLN A HB2    1 
ATOM   1845 H  HB3    . GLN A 1 128 ? 319.654 190.555 98.570  1.00 42.60 ? 128 GLN A HB3    1 
ATOM   1846 H  HG2    . GLN A 1 128 ? 318.157 192.030 96.776  1.00 40.04 ? 128 GLN A HG2    1 
ATOM   1847 H  HG3    . GLN A 1 128 ? 319.334 192.779 97.530  1.00 40.33 ? 128 GLN A HG3    1 
ATOM   1848 H  HE21   . GLN A 1 128 ? 318.726 191.414 94.815  1.00 37.78 ? 128 GLN A HE21   1 
ATOM   1849 H  HE22   . GLN A 1 128 ? 320.059 190.907 94.393  1.00 39.05 ? 128 GLN A HE22   1 
ATOM   1850 N  N      . ASP A 1 129 ? 316.880 189.003 100.340 1.00 45.60 ? 129 ASP A N      1 
ATOM   1851 C  CA     . ASP A 1 129 ? 316.884 188.025 101.417 1.00 46.19 ? 129 ASP A CA     1 
ATOM   1852 C  C      . ASP A 1 129 ? 316.496 186.635 100.938 1.00 50.67 ? 129 ASP A C      1 
ATOM   1853 O  O      . ASP A 1 129 ? 316.745 185.658 101.650 1.00 56.46 ? 129 ASP A O      1 
ATOM   1854 C  CB     . ASP A 1 129 ? 315.938 188.474 102.527 1.00 46.22 ? 129 ASP A CB     1 
ATOM   1855 C  CG     . ASP A 1 129 ? 314.533 188.718 102.029 1.00 49.29 ? 129 ASP A CG     1 
ATOM   1856 O  OD1    . ASP A 1 129 ? 314.383 189.094 100.851 1.00 50.78 ? 129 ASP A OD1    1 
ATOM   1857 O  OD2    . ASP A 1 129 ? 313.578 188.545 102.812 1.00 49.33 ? 129 ASP A OD2    1 
ATOM   1858 H  H      . ASP A 1 129 ? 316.243 189.571 100.383 1.00 45.27 ? 129 ASP A H      1 
ATOM   1859 H  HA     . ASP A 1 129 ? 317.776 187.978 101.785 1.00 46.44 ? 129 ASP A HA     1 
ATOM   1860 H  HB2    . ASP A 1 129 ? 315.902 187.787 103.208 1.00 48.14 ? 129 ASP A HB2    1 
ATOM   1861 H  HB3    . ASP A 1 129 ? 316.267 189.304 102.904 1.00 46.25 ? 129 ASP A HB3    1 
ATOM   1862 N  N      . LEU A 1 130 ? 315.879 186.528 99.774  1.00 48.63 ? 130 LEU A N      1 
ATOM   1863 C  CA     . LEU A 1 130 ? 315.453 185.239 99.254  1.00 50.63 ? 130 LEU A CA     1 
ATOM   1864 C  C      . LEU A 1 130 ? 316.651 184.488 98.674  1.00 55.75 ? 130 LEU A C      1 
ATOM   1865 O  O      . LEU A 1 130 ? 317.551 185.107 98.102  1.00 55.26 ? 130 LEU A O      1 
ATOM   1866 C  CB     . LEU A 1 130 ? 314.381 185.426 98.186  1.00 50.10 ? 130 LEU A CB     1 
ATOM   1867 C  CG     . LEU A 1 130 ? 312.936 185.542 98.677  1.00 49.60 ? 130 LEU A CG     1 
ATOM   1868 C  CD1    . LEU A 1 130 ? 312.881 186.240 99.999  1.00 47.36 ? 130 LEU A CD1    1 
ATOM   1869 C  CD2    . LEU A 1 130 ? 312.077 186.284 97.678  1.00 48.44 ? 130 LEU A CD2    1 
ATOM   1870 H  H      . LEU A 1 130 ? 315.686 187.188 99.263  1.00 48.03 ? 130 LEU A H      1 
ATOM   1871 H  HA     . LEU A 1 130 ? 315.076 184.724 99.976  1.00 50.43 ? 130 LEU A HA     1 
ATOM   1872 H  HB2    . LEU A 1 130 ? 314.580 186.238 97.703  1.00 48.70 ? 130 LEU A HB2    1 
ATOM   1873 H  HB3    . LEU A 1 130 ? 314.420 184.671 97.585  1.00 50.17 ? 130 LEU A HB3    1 
ATOM   1874 H  HG     . LEU A 1 130 ? 312.566 184.656 98.793  1.00 49.42 ? 130 LEU A HG     1 
ATOM   1875 H  HD11   . LEU A 1 130 ? 313.141 185.619 100.694 1.00 48.92 ? 130 LEU A HD11   1 
ATOM   1876 H  HD12   . LEU A 1 130 ? 311.975 186.550 100.147 1.00 47.51 ? 130 LEU A HD12   1 
ATOM   1877 H  HD13   . LEU A 1 130 ? 313.489 186.990 99.976  1.00 47.77 ? 130 LEU A HD13   1 
ATOM   1878 H  HD21   . LEU A 1 130 ? 312.454 187.163 97.539  1.00 46.50 ? 130 LEU A HD21   1 
ATOM   1879 H  HD22   . LEU A 1 130 ? 311.180 186.370 98.035  1.00 47.16 ? 130 LEU A HD22   1 
ATOM   1880 H  HD23   . LEU A 1 130 ? 312.059 185.793 96.843  1.00 48.49 ? 130 LEU A HD23   1 
ATOM   1881 N  N      . PRO A 1 131 ? 316.694 183.159 98.812  1.00 60.14 ? 131 PRO A N      1 
ATOM   1882 C  CA     . PRO A 1 131 ? 317.899 182.428 98.383  1.00 62.33 ? 131 PRO A CA     1 
ATOM   1883 C  C      . PRO A 1 131 ? 318.161 182.517 96.893  1.00 60.09 ? 131 PRO A C      1 
ATOM   1884 O  O      . PRO A 1 131 ? 319.318 182.623 96.471  1.00 55.73 ? 131 PRO A O      1 
ATOM   1885 C  CB     . PRO A 1 131 ? 317.606 180.984 98.819  1.00 59.98 ? 131 PRO A CB     1 
ATOM   1886 C  CG     . PRO A 1 131 ? 316.398 181.055 99.692  1.00 56.64 ? 131 PRO A CG     1 
ATOM   1887 C  CD     . PRO A 1 131 ? 315.636 182.243 99.256  1.00 54.59 ? 131 PRO A CD     1 
ATOM   1888 H  HA     . PRO A 1 131 ? 318.677 182.750 98.862  1.00 58.89 ? 131 PRO A HA     1 
ATOM   1889 H  HB2    . PRO A 1 131 ? 317.426 180.443 98.035  1.00 58.75 ? 131 PRO A HB2    1 
ATOM   1890 H  HB3    . PRO A 1 131 ? 318.364 180.637 99.311  1.00 58.72 ? 131 PRO A HB3    1 
ATOM   1891 H  HG2    . PRO A 1 131 ? 315.866 180.254 99.577  1.00 56.83 ? 131 PRO A HG2    1 
ATOM   1892 H  HG3    . PRO A 1 131 ? 316.672 181.155 100.615 1.00 57.09 ? 131 PRO A HG3    1 
ATOM   1893 H  HD2    . PRO A 1 131 ? 315.056 182.018 98.516  1.00 54.47 ? 131 PRO A HD2    1 
ATOM   1894 H  HD3    . PRO A 1 131 ? 315.143 182.609 100.005 1.00 54.60 ? 131 PRO A HD3    1 
ATOM   1895 N  N      . GLU A 1 132 ? 317.110 182.469 96.083  1.00 59.74 ? 132 GLU A N      1 
ATOM   1896 C  CA     . GLU A 1 132 ? 317.229 182.481 94.632  1.00 61.16 ? 132 GLU A CA     1 
ATOM   1897 C  C      . GLU A 1 132 ? 317.399 183.879 94.068  1.00 61.71 ? 132 GLU A C      1 
ATOM   1898 O  O      . GLU A 1 132 ? 317.318 184.057 92.848  1.00 60.24 ? 132 GLU A O      1 
ATOM   1899 C  CB     . GLU A 1 132 ? 316.002 181.826 94.000  1.00 63.62 ? 132 GLU A CB     1 
ATOM   1900 C  CG     . GLU A 1 132 ? 315.656 180.467 94.575  1.00 64.71 ? 132 GLU A CG     1 
ATOM   1901 C  CD     . GLU A 1 132 ? 316.635 179.390 94.158  1.00 71.93 ? 132 GLU A CD     1 
ATOM   1902 O  OE1    . GLU A 1 132 ? 316.854 178.449 94.949  1.00 70.52 ? 132 GLU A OE1    1 
ATOM   1903 O  OE2    . GLU A 1 132 ? 317.188 179.484 93.043  1.00 76.93 ? 132 GLU A OE2    1 
ATOM   1904 H  H      . GLU A 1 132 ? 316.299 182.427 96.360  1.00 59.78 ? 132 GLU A H      1 
ATOM   1905 H  HA     . GLU A 1 132 ? 318.007 181.964 94.380  1.00 62.17 ? 132 GLU A HA     1 
ATOM   1906 H  HB2    . GLU A 1 132 ? 315.241 182.407 94.147  1.00 61.87 ? 132 GLU A HB2    1 
ATOM   1907 H  HB3    . GLU A 1 132 ? 316.160 181.719 93.051  1.00 63.44 ? 132 GLU A HB3    1 
ATOM   1908 H  HG2    . GLU A 1 132 ? 315.678 180.519 95.541  1.00 64.07 ? 132 GLU A HG2    1 
ATOM   1909 H  HG3    . GLU A 1 132 ? 314.765 180.221 94.277  1.00 64.36 ? 132 GLU A HG3    1 
ATOM   1910 N  N      . ALA A 1 133 ? 317.635 184.871 94.915  1.00 60.00 ? 133 ALA A N      1 
ATOM   1911 C  CA     . ALA A 1 133 ? 317.762 186.232 94.430  1.00 53.58 ? 133 ALA A CA     1 
ATOM   1912 C  C      . ALA A 1 133 ? 318.967 186.358 93.509  1.00 54.06 ? 133 ALA A C      1 
ATOM   1913 O  O      . ALA A 1 133 ? 319.966 185.646 93.647  1.00 56.10 ? 133 ALA A O      1 
ATOM   1914 C  CB     . ALA A 1 133 ? 317.891 187.210 95.593  1.00 50.60 ? 133 ALA A CB     1 
ATOM   1915 H  H      . ALA A 1 133 ? 317.727 184.782 95.763  1.00 58.13 ? 133 ALA A H      1 
ATOM   1916 H  HA     . ALA A 1 133 ? 316.968 186.467 93.930  1.00 52.74 ? 133 ALA A HA     1 
ATOM   1917 H  HB1    . ALA A 1 133 ? 317.091 187.166 96.137  1.00 50.79 ? 133 ALA A HB1    1 
ATOM   1918 H  HB2    . ALA A 1 133 ? 317.997 188.101 95.235  1.00 48.13 ? 133 ALA A HB2    1 
ATOM   1919 H  HB3    . ALA A 1 133 ? 318.671 186.971 96.116  1.00 50.85 ? 133 ALA A HB3    1 
ATOM   1920 N  N      . MET A 1 134 ? 318.869 187.300 92.585  1.00 49.95 ? 134 MET A N      1 
ATOM   1921 C  CA     . MET A 1 134 ? 319.876 187.543 91.568  1.00 49.19 ? 134 MET A CA     1 
ATOM   1922 C  C      . MET A 1 134 ? 320.658 188.802 91.909  1.00 47.97 ? 134 MET A C      1 
ATOM   1923 O  O      . MET A 1 134 ? 320.098 189.772 92.424  1.00 47.49 ? 134 MET A O      1 
ATOM   1924 C  CB     . MET A 1 134 ? 319.239 187.661 90.183  1.00 47.84 ? 134 MET A CB     1 
ATOM   1925 C  CG     . MET A 1 134 ? 317.883 188.327 90.153  1.00 51.14 ? 134 MET A CG     1 
ATOM   1926 S  SD     . MET A 1 134 ? 316.966 187.999 88.647  1.00 59.75 ? 134 MET A SD     1 
ATOM   1927 C  CE     . MET A 1 134 ? 318.156 188.550 87.451  1.00 48.68 ? 134 MET A CE     1 
ATOM   1928 H  H      . MET A 1 134 ? 318.208 187.842 92.547  1.00 49.56 ? 134 MET A H      1 
ATOM   1929 H  HA     . MET A 1 134 ? 320.490 186.801 91.556  1.00 51.46 ? 134 MET A HA     1 
ATOM   1930 H  HB2    . MET A 1 134 ? 319.822 188.194 89.631  1.00 49.35 ? 134 MET A HB2    1 
ATOM   1931 H  HB3    . MET A 1 134 ? 319.148 186.777 89.802  1.00 51.07 ? 134 MET A HB3    1 
ATOM   1932 H  HG2    . MET A 1 134 ? 317.348 188.012 90.889  1.00 50.61 ? 134 MET A HG2    1 
ATOM   1933 H  HG3    . MET A 1 134 ? 318.012 189.280 90.216  1.00 49.75 ? 134 MET A HG3    1 
ATOM   1934 H  HE1    . MET A 1 134 ? 318.303 189.496 87.584  1.00 49.29 ? 134 MET A HE1    1 
ATOM   1935 H  HE2    . MET A 1 134 ? 317.814 188.385 86.562  1.00 51.03 ? 134 MET A HE2    1 
ATOM   1936 H  HE3    . MET A 1 134 ? 318.979 188.061 87.590  1.00 49.70 ? 134 MET A HE3    1 
ATOM   1937 N  N      . SER A 1 135 ? 321.955 188.772 91.632  1.00 47.07 ? 135 SER A N      1 
ATOM   1938 C  CA     . SER A 1 135 ? 322.842 189.832 92.076  1.00 42.93 ? 135 SER A CA     1 
ATOM   1939 C  C      . SER A 1 135 ? 322.507 191.146 91.383  1.00 43.29 ? 135 SER A C      1 
ATOM   1940 O  O      . SER A 1 135 ? 321.846 191.189 90.344  1.00 44.23 ? 135 SER A O      1 
ATOM   1941 C  CB     . SER A 1 135 ? 324.297 189.463 91.807  1.00 44.29 ? 135 SER A CB     1 
ATOM   1942 O  OG     . SER A 1 135 ? 325.159 190.507 92.215  1.00 48.48 ? 135 SER A OG     1 
ATOM   1943 H  H      . SER A 1 135 ? 322.343 188.147 91.193  1.00 46.99 ? 135 SER A H      1 
ATOM   1944 H  HA     . SER A 1 135 ? 322.733 189.961 93.027  1.00 43.59 ? 135 SER A HA     1 
ATOM   1945 H  HB2    . SER A 1 135 ? 324.518 188.655 92.295  1.00 45.06 ? 135 SER A HB2    1 
ATOM   1946 H  HB3    . SER A 1 135 ? 324.405 189.318 90.855  1.00 44.64 ? 135 SER A HB3    1 
ATOM   1947 H  HG     . SER A 1 135 ? 324.880 190.831 92.939  1.00 46.84 ? 135 SER A HG     1 
ATOM   1948 N  N      . ALA A 1 136 ? 322.985 192.237 91.979  1.00 41.11 ? 136 ALA A N      1 
ATOM   1949 C  CA     . ALA A 1 136 ? 322.785 193.552 91.397  1.00 37.24 ? 136 ALA A CA     1 
ATOM   1950 C  C      . ALA A 1 136 ? 323.515 193.716 90.078  1.00 39.43 ? 136 ALA A C      1 
ATOM   1951 O  O      . ALA A 1 136 ? 323.094 194.523 89.248  1.00 39.55 ? 136 ALA A O      1 
ATOM   1952 C  CB     . ALA A 1 136 ? 323.239 194.642 92.364  1.00 35.12 ? 136 ALA A CB     1 
ATOM   1953 H  H      . ALA A 1 136 ? 323.430 192.240 92.710  1.00 41.89 ? 136 ALA A H      1 
ATOM   1954 H  HA     . ALA A 1 136 ? 321.843 193.678 91.236  1.00 38.79 ? 136 ALA A HA     1 
ATOM   1955 H  HB1    . ALA A 1 136 ? 324.193 194.766 92.256  1.00 37.71 ? 136 ALA A HB1    1 
ATOM   1956 H  HB2    . ALA A 1 136 ? 323.038 194.384 93.275  1.00 36.54 ? 136 ALA A HB2    1 
ATOM   1957 H  HB3    . ALA A 1 136 ? 322.768 195.454 92.130  1.00 36.91 ? 136 ALA A HB3    1 
ATOM   1958 N  N      . ALA A 1 137 ? 324.607 192.984 89.871  1.00 36.94 ? 137 ALA A N      1 
ATOM   1959 C  CA     . ALA A 1 137 ? 325.320 193.055 88.602  1.00 36.36 ? 137 ALA A CA     1 
ATOM   1960 C  C      . ALA A 1 137 ? 324.596 192.275 87.516  1.00 41.29 ? 137 ALA A C      1 
ATOM   1961 O  O      . ALA A 1 137 ? 324.557 192.701 86.357  1.00 42.45 ? 137 ALA A O      1 
ATOM   1962 C  CB     . ALA A 1 137 ? 326.737 192.527 88.771  1.00 34.51 ? 137 ALA A CB     1 
ATOM   1963 H  H      . ALA A 1 137 ? 324.949 192.449 90.444  1.00 38.64 ? 137 ALA A H      1 
ATOM   1964 H  HA     . ALA A 1 137 ? 325.376 193.979 88.324  1.00 37.76 ? 137 ALA A HA     1 
ATOM   1965 H  HB1    . ALA A 1 137 ? 327.205 192.618 87.929  1.00 35.81 ? 137 ALA A HB1    1 
ATOM   1966 H  HB2    . ALA A 1 137 ? 326.690 191.596 89.032  1.00 36.34 ? 137 ALA A HB2    1 
ATOM   1967 H  HB3    . ALA A 1 137 ? 327.180 193.046 89.457  1.00 36.52 ? 137 ALA A HB3    1 
ATOM   1968 N  N      . GLU A 1 138 ? 324.032 191.124 87.872  1.00 44.22 ? 138 GLU A N      1 
ATOM   1969 C  CA     . GLU A 1 138 ? 323.203 190.388 86.929  1.00 42.40 ? 138 GLU A CA     1 
ATOM   1970 C  C      . GLU A 1 138 ? 322.000 191.215 86.503  1.00 42.20 ? 138 GLU A C      1 
ATOM   1971 O  O      . GLU A 1 138 ? 321.598 191.189 85.335  1.00 47.30 ? 138 GLU A O      1 
ATOM   1972 C  CB     . GLU A 1 138 ? 322.764 189.069 87.558  1.00 46.82 ? 138 GLU A CB     1 
ATOM   1973 C  CG     . GLU A 1 138 ? 321.908 188.211 86.664  1.00 55.77 ? 138 GLU A CG     1 
ATOM   1974 C  CD     . GLU A 1 138 ? 321.727 186.803 87.197  1.00 63.89 ? 138 GLU A CD     1 
ATOM   1975 O  OE1    . GLU A 1 138 ? 322.216 186.517 88.310  1.00 62.48 ? 138 GLU A OE1    1 
ATOM   1976 O  OE2    . GLU A 1 138 ? 321.097 185.980 86.500  1.00 60.89 ? 138 GLU A OE2    1 
ATOM   1977 H  H      . GLU A 1 138 ? 324.119 190.756 88.641  1.00 43.86 ? 138 GLU A H      1 
ATOM   1978 H  HA     . GLU A 1 138 ? 323.724 190.188 86.141  1.00 43.97 ? 138 GLU A HA     1 
ATOM   1979 H  HB2    . GLU A 1 138 ? 323.552 188.560 87.798  1.00 47.00 ? 138 GLU A HB2    1 
ATOM   1980 H  HB3    . GLU A 1 138 ? 322.253 189.267 88.351  1.00 47.53 ? 138 GLU A HB3    1 
ATOM   1981 H  HG2    . GLU A 1 138 ? 321.033 188.618 86.594  1.00 53.74 ? 138 GLU A HG2    1 
ATOM   1982 H  HG3    . GLU A 1 138 ? 322.324 188.157 85.791  1.00 54.38 ? 138 GLU A HG3    1 
ATOM   1983 N  N      . ILE A 1 139 ? 321.431 191.981 87.431  1.00 37.43 ? 139 ILE A N      1 
ATOM   1984 C  CA     . ILE A 1 139 ? 320.319 192.861 87.093  1.00 36.95 ? 139 ILE A CA     1 
ATOM   1985 C  C      . ILE A 1 139 ? 320.805 194.043 86.266  1.00 35.40 ? 139 ILE A C      1 
ATOM   1986 O  O      . ILE A 1 139 ? 320.137 194.474 85.321  1.00 38.04 ? 139 ILE A O      1 
ATOM   1987 C  CB     . ILE A 1 139 ? 319.604 193.315 88.377  1.00 36.19 ? 139 ILE A CB     1 
ATOM   1988 C  CG1    . ILE A 1 139 ? 318.778 192.166 88.946  1.00 35.57 ? 139 ILE A CG1    1 
ATOM   1989 C  CG2    . ILE A 1 139 ? 318.731 194.510 88.105  1.00 35.02 ? 139 ILE A CG2    1 
ATOM   1990 C  CD1    . ILE A 1 139 ? 318.064 192.492 90.204  1.00 36.04 ? 139 ILE A CD1    1 
ATOM   1991 H  H      . ILE A 1 139 ? 321.670 192.003 88.252  1.00 39.74 ? 139 ILE A H      1 
ATOM   1992 H  HA     . ILE A 1 139 ? 319.686 192.373 86.555  1.00 38.82 ? 139 ILE A HA     1 
ATOM   1993 H  HB     . ILE A 1 139 ? 320.268 193.561 89.032  1.00 38.16 ? 139 ILE A HB     1 
ATOM   1994 H  HG12   . ILE A 1 139 ? 318.115 191.905 88.293  1.00 38.04 ? 139 ILE A HG12   1 
ATOM   1995 H  HG13   . ILE A 1 139 ? 319.374 191.432 89.136  1.00 39.45 ? 139 ILE A HG13   1 
ATOM   1996 H  HG21   . ILE A 1 139 ? 318.115 194.286 87.394  1.00 35.72 ? 139 ILE A HG21   1 
ATOM   1997 H  HG22   . ILE A 1 139 ? 319.284 195.259 87.846  1.00 35.32 ? 139 ILE A HG22   1 
ATOM   1998 H  HG23   . ILE A 1 139 ? 318.246 194.736 88.909  1.00 35.21 ? 139 ILE A HG23   1 
ATOM   1999 H  HD11   . ILE A 1 139 ? 317.340 193.101 90.003  1.00 36.50 ? 139 ILE A HD11   1 
ATOM   2000 H  HD12   . ILE A 1 139 ? 318.696 192.907 90.805  1.00 36.80 ? 139 ILE A HD12   1 
ATOM   2001 H  HD13   . ILE A 1 139 ? 317.711 191.679 90.593  1.00 39.49 ? 139 ILE A HD13   1 
ATOM   2002 N  N      . THR A 1 140 ? 321.968 194.590 86.612  1.00 34.24 ? 140 THR A N      1 
ATOM   2003 C  CA     . THR A 1 140 ? 322.533 195.688 85.842  1.00 32.93 ? 140 THR A CA     1 
ATOM   2004 C  C      . THR A 1 140 ? 322.782 195.269 84.404  1.00 35.45 ? 140 THR A C      1 
ATOM   2005 O  O      . THR A 1 140 ? 322.713 196.091 83.484  1.00 37.16 ? 140 THR A O      1 
ATOM   2006 C  CB     . THR A 1 140 ? 323.833 196.155 86.489  1.00 35.66 ? 140 THR A CB     1 
ATOM   2007 O  OG1    . THR A 1 140 ? 323.582 196.587 87.830  1.00 36.65 ? 140 THR A OG1    1 
ATOM   2008 C  CG2    . THR A 1 140 ? 324.436 197.274 85.713  1.00 35.62 ? 140 THR A CG2    1 
ATOM   2009 H  H      . THR A 1 140 ? 322.446 194.341 87.277  1.00 36.60 ? 140 THR A H      1 
ATOM   2010 H  HA     . THR A 1 140 ? 321.918 196.431 85.840  1.00 34.49 ? 140 THR A HA     1 
ATOM   2011 H  HB     . THR A 1 140 ? 324.464 195.425 86.500  1.00 36.78 ? 140 THR A HB     1 
ATOM   2012 H  HG1    . THR A 1 140 ? 324.264 196.972 88.130  1.00 36.83 ? 140 THR A HG1    1 
ATOM   2013 H  HG21   . THR A 1 140 ? 324.704 196.960 84.839  1.00 35.42 ? 140 THR A HG21   1 
ATOM   2014 H  HG22   . THR A 1 140 ? 325.216 197.601 86.186  1.00 35.96 ? 140 THR A HG22   1 
ATOM   2015 H  HG23   . THR A 1 140 ? 323.792 197.988 85.615  1.00 36.16 ? 140 THR A HG23   1 
ATOM   2016 N  N      . GLU A 1 141 ? 323.101 193.995 84.194  1.00 41.21 ? 141 GLU A N      1 
ATOM   2017 C  CA     . GLU A 1 141 ? 323.303 193.495 82.841  1.00 41.47 ? 141 GLU A CA     1 
ATOM   2018 C  C      . GLU A 1 141 ? 321.968 193.226 82.156  1.00 38.35 ? 141 GLU A C      1 
ATOM   2019 O  O      . GLU A 1 141 ? 321.783 193.564 80.983  1.00 40.33 ? 141 GLU A O      1 
ATOM   2020 C  CB     . GLU A 1 141 ? 324.172 192.239 82.891  1.00 42.77 ? 141 GLU A CB     1 
ATOM   2021 C  CG     . GLU A 1 141 ? 324.125 191.345 81.664  1.00 53.24 ? 141 GLU A CG     1 
ATOM   2022 C  CD     . GLU A 1 141 ? 324.695 189.962 81.931  1.00 63.44 ? 141 GLU A CD     1 
ATOM   2023 O  OE1    . GLU A 1 141 ? 324.450 189.418 83.030  1.00 57.89 ? 141 GLU A OE1    1 
ATOM   2024 O  OE2    . GLU A 1 141 ? 325.381 189.414 81.043  1.00 69.82 ? 141 GLU A OE2    1 
ATOM   2025 H  H      . GLU A 1 141 ? 323.200 193.405 84.807  1.00 40.83 ? 141 GLU A H      1 
ATOM   2026 H  HA     . GLU A 1 141 ? 323.776 194.161 82.324  1.00 41.09 ? 141 GLU A HA     1 
ATOM   2027 H  HB2    . GLU A 1 141 ? 325.093 192.516 83.000  1.00 42.96 ? 141 GLU A HB2    1 
ATOM   2028 H  HB3    . GLU A 1 141 ? 323.900 191.714 83.657  1.00 44.71 ? 141 GLU A HB3    1 
ATOM   2029 H  HG2    . GLU A 1 141 ? 323.211 191.232 81.373  1.00 51.65 ? 141 GLU A HG2    1 
ATOM   2030 H  HG3    . GLU A 1 141 ? 324.652 191.755 80.961  1.00 52.82 ? 141 GLU A HG3    1 
ATOM   2031 N  N      . LYS A 1 142 ? 321.023 192.617 82.874  1.00 37.42 ? 142 LYS A N      1 
ATOM   2032 C  CA     . LYS A 1 142 ? 319.747 192.264 82.263  1.00 36.56 ? 142 LYS A CA     1 
ATOM   2033 C  C      . LYS A 1 142 ? 318.901 193.490 81.951  1.00 37.55 ? 142 LYS A C      1 
ATOM   2034 O  O      . LYS A 1 142 ? 318.160 193.489 80.963  1.00 37.83 ? 142 LYS A O      1 
ATOM   2035 C  CB     . LYS A 1 142 ? 318.977 191.318 83.175  1.00 39.56 ? 142 LYS A CB     1 
ATOM   2036 C  CG     . LYS A 1 142 ? 319.359 189.859 83.047  1.00 45.27 ? 142 LYS A CG     1 
ATOM   2037 C  CD     . LYS A 1 142 ? 318.276 188.969 83.605  1.00 51.77 ? 142 LYS A CD     1 
ATOM   2038 C  CE     . LYS A 1 142 ? 318.686 187.507 83.627  1.00 55.98 ? 142 LYS A CE     1 
ATOM   2039 N  NZ     . LYS A 1 142 ? 319.903 187.258 84.434  1.00 54.82 ? 142 LYS A NZ     1 
ATOM   2040 H  H      . LYS A 1 142 ? 321.091 192.394 83.699  1.00 40.29 ? 142 LYS A H      1 
ATOM   2041 H  HA     . LYS A 1 142 ? 319.914 191.806 81.431  1.00 39.62 ? 142 LYS A HA     1 
ATOM   2042 H  HB2    . LYS A 1 142 ? 319.137 191.581 84.090  1.00 40.05 ? 142 LYS A HB2    1 
ATOM   2043 H  HB3    . LYS A 1 142 ? 318.037 191.395 82.966  1.00 40.97 ? 142 LYS A HB3    1 
ATOM   2044 H  HG2    . LYS A 1 142 ? 319.497 189.636 82.115  1.00 44.69 ? 142 LYS A HG2    1 
ATOM   2045 H  HG3    . LYS A 1 142 ? 320.166 189.701 83.558  1.00 45.98 ? 142 LYS A HG3    1 
ATOM   2046 H  HD2    . LYS A 1 142 ? 318.078 189.251 84.508  1.00 50.19 ? 142 LYS A HD2    1 
ATOM   2047 H  HD3    . LYS A 1 142 ? 317.489 189.048 83.046  1.00 48.99 ? 142 LYS A HD3    1 
ATOM   2048 H  HE2    . LYS A 1 142 ? 317.966 186.984 84.010  1.00 54.77 ? 142 LYS A HE2    1 
ATOM   2049 H  HE3    . LYS A 1 142 ? 318.859 187.212 82.720  1.00 53.88 ? 142 LYS A HE3    1 
ATOM   2050 H  HZ1    . LYS A 1 142 ? 320.589 187.710 84.092  1.00 52.54 ? 142 LYS A HZ1    1 
ATOM   2051 H  HZ2    . LYS A 1 142 ? 320.097 186.390 84.428  1.00 56.40 ? 142 LYS A HZ2    1 
ATOM   2052 H  HZ3    . LYS A 1 142 ? 319.766 187.517 85.274  1.00 53.82 ? 142 LYS A HZ3    1 
ATOM   2053 N  N      . LEU A 1 143 ? 318.998 194.542 82.760  1.00 39.63 ? 143 LEU A N      1 
ATOM   2054 C  CA     . LEU A 1 143 ? 318.208 195.744 82.533  1.00 35.66 ? 143 LEU A CA     1 
ATOM   2055 C  C      . LEU A 1 143 ? 318.836 196.701 81.530  1.00 33.94 ? 143 LEU A C      1 
ATOM   2056 O  O      . LEU A 1 143 ? 318.195 197.693 81.169  1.00 32.98 ? 143 LEU A O      1 
ATOM   2057 C  CB     . LEU A 1 143 ? 317.991 196.487 83.847  1.00 33.30 ? 143 LEU A CB     1 
ATOM   2058 C  CG     . LEU A 1 143 ? 317.136 195.854 84.934  1.00 34.41 ? 143 LEU A CG     1 
ATOM   2059 C  CD1    . LEU A 1 143 ? 317.175 196.735 86.131  1.00 34.42 ? 143 LEU A CD1    1 
ATOM   2060 C  CD2    . LEU A 1 143 ? 315.725 195.691 84.485  1.00 33.80 ? 143 LEU A CD2    1 
ATOM   2061 H  H      . LEU A 1 143 ? 319.515 194.581 83.441  1.00 38.41 ? 143 LEU A H      1 
ATOM   2062 H  HA     . LEU A 1 143 ? 317.342 195.484 82.198  1.00 36.95 ? 143 LEU A HA     1 
ATOM   2063 H  HB2    . LEU A 1 143 ? 318.858 196.655 84.238  1.00 35.02 ? 143 LEU A HB2    1 
ATOM   2064 H  HB3    . LEU A 1 143 ? 317.570 197.329 83.630  1.00 34.34 ? 143 LEU A HB3    1 
ATOM   2065 H  HG     . LEU A 1 143 ? 317.489 194.986 85.170  1.00 36.01 ? 143 LEU A HG     1 
ATOM   2066 H  HD11   . LEU A 1 143 ? 316.793 197.587 85.886  1.00 34.50 ? 143 LEU A HD11   1 
ATOM   2067 H  HD12   . LEU A 1 143 ? 318.094 196.848 86.406  1.00 34.19 ? 143 LEU A HD12   1 
ATOM   2068 H  HD13   . LEU A 1 143 ? 316.659 196.331 86.840  1.00 34.43 ? 143 LEU A HD13   1 
ATOM   2069 H  HD21   . LEU A 1 143 ? 315.146 196.068 85.162  1.00 35.65 ? 143 LEU A HD21   1 
ATOM   2070 H  HD22   . LEU A 1 143 ? 315.609 196.164 83.651  1.00 35.86 ? 143 LEU A HD22   1 
ATOM   2071 H  HD23   . LEU A 1 143 ? 315.541 194.748 84.372  1.00 36.23 ? 143 LEU A HD23   1 
ATOM   2072 N  N      . GLY A 1 144 ? 320.065 196.455 81.094  1.00 35.36 ? 144 GLY A N      1 
ATOM   2073 C  CA     . GLY A 1 144 ? 320.718 197.361 80.171  1.00 34.79 ? 144 GLY A CA     1 
ATOM   2074 C  C      . GLY A 1 144 ? 320.908 198.743 80.748  1.00 36.85 ? 144 GLY A C      1 
ATOM   2075 O  O      . GLY A 1 144 ? 320.525 199.744 80.137  1.00 40.25 ? 144 GLY A O      1 
ATOM   2076 H  H      . GLY A 1 144 ? 320.538 195.780 81.330  1.00 36.72 ? 144 GLY A H      1 
ATOM   2077 H  HA2    . GLY A 1 144 ? 321.591 197.015 79.932  1.00 35.71 ? 144 GLY A HA2    1 
ATOM   2078 H  HA3    . GLY A 1 144 ? 320.178 197.439 79.374  1.00 37.71 ? 144 GLY A HA3    1 
ATOM   2079 N  N      . LEU A 1 145 ? 321.514 198.801 81.930  1.00 34.51 ? 145 LEU A N      1 
ATOM   2080 C  CA     . LEU A 1 145 ? 321.670 200.059 82.642  1.00 31.43 ? 145 LEU A CA     1 
ATOM   2081 C  C      . LEU A 1 145 ? 322.901 200.826 82.192  1.00 33.78 ? 145 LEU A C      1 
ATOM   2082 O  O      . LEU A 1 145 ? 322.911 202.059 82.249  1.00 34.21 ? 145 LEU A O      1 
ATOM   2083 C  CB     . LEU A 1 145 ? 321.736 199.794 84.140  1.00 29.96 ? 145 LEU A CB     1 
ATOM   2084 C  CG     . LEU A 1 145 ? 320.415 199.610 84.877  1.00 27.07 ? 145 LEU A CG     1 
ATOM   2085 C  CD1    . LEU A 1 145 ? 320.688 199.421 86.323  1.00 27.83 ? 145 LEU A CD1    1 
ATOM   2086 C  CD2    . LEU A 1 145 ? 319.511 200.780 84.687  1.00 29.90 ? 145 LEU A CD2    1 
ATOM   2087 H  H      . LEU A 1 145 ? 321.851 198.127 82.335  1.00 34.57 ? 145 LEU A H      1 
ATOM   2088 H  HA     . LEU A 1 145 ? 320.906 200.615 82.465  1.00 32.27 ? 145 LEU A HA     1 
ATOM   2089 H  HB2    . LEU A 1 145 ? 322.252 198.990 84.281  1.00 31.99 ? 145 LEU A HB2    1 
ATOM   2090 H  HB3    . LEU A 1 145 ? 322.181 200.541 84.553  1.00 31.57 ? 145 LEU A HB3    1 
ATOM   2091 H  HG     . LEU A 1 145 ? 319.968 198.822 84.549  1.00 30.92 ? 145 LEU A HG     1 
ATOM   2092 H  HD11   . LEU A 1 145 ? 321.246 198.641 86.434  1.00 30.48 ? 145 LEU A HD11   1 
ATOM   2093 H  HD12   . LEU A 1 145 ? 319.846 199.304 86.781  1.00 28.45 ? 145 LEU A HD12   1 
ATOM   2094 H  HD13   . LEU A 1 145 ? 321.144 200.205 86.654  1.00 29.52 ? 145 LEU A HD13   1 
ATOM   2095 H  HD21   . LEU A 1 145 ? 318.747 200.668 85.267  1.00 29.94 ? 145 LEU A HD21   1 
ATOM   2096 H  HD22   . LEU A 1 145 ? 319.226 200.819 83.765  1.00 31.73 ? 145 LEU A HD22   1 
ATOM   2097 H  HD23   . LEU A 1 145 ? 319.997 201.581 84.924  1.00 31.41 ? 145 LEU A HD23   1 
ATOM   2098 N  N      . HIS A 1 146 ? 323.939 200.127 81.745  1.00 33.60 ? 146 HIS A N      1 
ATOM   2099 C  CA     . HIS A 1 146 ? 325.109 200.814 81.217  1.00 34.59 ? 146 HIS A CA     1 
ATOM   2100 C  C      . HIS A 1 146 ? 324.803 201.558 79.929  1.00 34.48 ? 146 HIS A C      1 
ATOM   2101 O  O      . HIS A 1 146 ? 325.545 202.476 79.568  1.00 39.09 ? 146 HIS A O      1 
ATOM   2102 C  CB     . HIS A 1 146 ? 326.233 199.819 80.980  1.00 36.03 ? 146 HIS A CB     1 
ATOM   2103 C  CG     . HIS A 1 146 ? 326.860 199.302 82.233  1.00 42.42 ? 146 HIS A CG     1 
ATOM   2104 N  ND1    . HIS A 1 146 ? 327.629 200.091 83.060  1.00 39.71 ? 146 HIS A ND1    1 
ATOM   2105 C  CD2    . HIS A 1 146 ? 326.843 198.072 82.796  1.00 43.08 ? 146 HIS A CD2    1 
ATOM   2106 C  CE1    . HIS A 1 146 ? 328.052 199.371 84.082  1.00 37.00 ? 146 HIS A CE1    1 
ATOM   2107 N  NE2    . HIS A 1 146 ? 327.590 198.142 83.945  1.00 44.27 ? 146 HIS A NE2    1 
ATOM   2108 H  H      . HIS A 1 146 ? 323.995 199.273 81.744  1.00 34.37 ? 146 HIS A H      1 
ATOM   2109 H  HA     . HIS A 1 146 ? 325.416 201.454 81.867  1.00 35.82 ? 146 HIS A HA     1 
ATOM   2110 H  HB2    . HIS A 1 146 ? 325.875 199.060 80.499  1.00 36.32 ? 146 HIS A HB2    1 
ATOM   2111 H  HB3    . HIS A 1 146 ? 326.920 200.258 80.461  1.00 36.95 ? 146 HIS A HB3    1 
ATOM   2112 H  HD2    . HIS A 1 146 ? 326.405 197.324 82.464  1.00 40.04 ? 146 HIS A HD2    1 
ATOM   2113 H  HE1    . HIS A 1 146 ? 328.584 199.675 84.777  1.00 37.64 ? 146 HIS A HE1    1 
ATOM   2114 H  HE2    . HIS A 1 146 ? 327.737 197.495 84.487  1.00 42.44 ? 146 HIS A HE2    1 
ATOM   2115 N  N      . SER A 1 147 ? 323.730 201.189 79.238  1.00 32.69 ? 147 SER A N      1 
ATOM   2116 C  CA     . SER A 1 147 ? 323.295 201.897 78.046  1.00 29.38 ? 147 SER A CA     1 
ATOM   2117 C  C      . SER A 1 147 ? 322.769 203.288 78.340  1.00 31.01 ? 147 SER A C      1 
ATOM   2118 O  O      . SER A 1 147 ? 322.451 204.013 77.395  1.00 32.98 ? 147 SER A O      1 
ATOM   2119 C  CB     . SER A 1 147 ? 322.213 201.086 77.343  1.00 32.05 ? 147 SER A CB     1 
ATOM   2120 O  OG     . SER A 1 147 ? 322.635 199.756 77.118  1.00 36.89 ? 147 SER A OG     1 
ATOM   2121 H  H      . SER A 1 147 ? 323.237 200.516 79.438  1.00 33.77 ? 147 SER A H      1 
ATOM   2122 H  HA     . SER A 1 147 ? 324.040 201.989 77.441  1.00 31.25 ? 147 SER A HA     1 
ATOM   2123 H  HB2    . SER A 1 147 ? 321.424 201.071 77.903  1.00 33.04 ? 147 SER A HB2    1 
ATOM   2124 H  HB3    . SER A 1 147 ? 322.014 201.502 76.493  1.00 33.00 ? 147 SER A HB3    1 
ATOM   2125 H  HG     . SER A 1 147 ? 323.372 199.757 76.718  1.00 35.51 ? 147 SER A HG     1 
ATOM   2126 N  N      . ILE A 1 148 ? 322.654 203.668 79.605  1.00 33.71 ? 148 ILE A N      1 
ATOM   2127 C  CA     . ILE A 1 148 ? 322.120 204.967 79.984  1.00 31.77 ? 148 ILE A CA     1 
ATOM   2128 C  C      . ILE A 1 148 ? 323.228 205.998 79.856  1.00 34.51 ? 148 ILE A C      1 
ATOM   2129 O  O      . ILE A 1 148 ? 324.334 205.807 80.373  1.00 38.47 ? 148 ILE A O      1 
ATOM   2130 C  CB     . ILE A 1 148 ? 321.549 204.932 81.408  1.00 30.89 ? 148 ILE A CB     1 
ATOM   2131 C  CG1    . ILE A 1 148 ? 320.486 203.844 81.518  1.00 31.85 ? 148 ILE A CG1    1 
ATOM   2132 C  CG2    . ILE A 1 148 ? 320.953 206.254 81.761  1.00 30.90 ? 148 ILE A CG2    1 
ATOM   2133 C  CD1    . ILE A 1 148 ? 319.866 203.721 82.871  1.00 29.94 ? 148 ILE A CD1    1 
ATOM   2134 H  H      . ILE A 1 148 ? 322.886 203.190 80.274  1.00 33.83 ? 148 ILE A H      1 
ATOM   2135 H  HA     . ILE A 1 148 ? 321.409 205.217 79.382  1.00 32.06 ? 148 ILE A HA     1 
ATOM   2136 H  HB     . ILE A 1 148 ? 322.264 204.735 82.022  1.00 32.16 ? 148 ILE A HB     1 
ATOM   2137 H  HG12   . ILE A 1 148 ? 319.781 204.038 80.889  1.00 33.19 ? 148 ILE A HG12   1 
ATOM   2138 H  HG13   . ILE A 1 148 ? 320.894 202.995 81.306  1.00 32.68 ? 148 ILE A HG13   1 
ATOM   2139 H  HG21   . ILE A 1 148 ? 320.619 206.215 82.667  1.00 31.04 ? 148 ILE A HG21   1 
ATOM   2140 H  HG22   . ILE A 1 148 ? 320.231 206.436 81.146  1.00 31.08 ? 148 ILE A HG22   1 
ATOM   2141 H  HG23   . ILE A 1 148 ? 321.633 206.938 81.690  1.00 31.62 ? 148 ILE A HG23   1 
ATOM   2142 H  HD11   . ILE A 1 148 ? 320.567 203.629 83.528  1.00 30.53 ? 148 ILE A HD11   1 
ATOM   2143 H  HD12   . ILE A 1 148 ? 319.297 202.940 82.889  1.00 31.69 ? 148 ILE A HD12   1 
ATOM   2144 H  HD13   . ILE A 1 148 ? 319.346 204.514 83.055  1.00 31.47 ? 148 ILE A HD13   1 
ATOM   2145 N  N      . ARG A 1 149 ? 322.927 207.097 79.171  1.00 35.22 ? 149 ARG A N      1 
ATOM   2146 C  CA     . ARG A 1 149 ? 323.940 208.079 78.816  1.00 32.45 ? 149 ARG A CA     1 
ATOM   2147 C  C      . ARG A 1 149 ? 323.474 209.510 79.032  1.00 33.09 ? 149 ARG A C      1 
ATOM   2148 O  O      . ARG A 1 149 ? 324.314 210.413 79.134  1.00 32.98 ? 149 ARG A O      1 
ATOM   2149 C  CB     . ARG A 1 149 ? 324.341 207.894 77.359  1.00 34.64 ? 149 ARG A CB     1 
ATOM   2150 C  CG     . ARG A 1 149 ? 323.161 207.770 76.423  1.00 38.18 ? 149 ARG A CG     1 
ATOM   2151 C  CD     . ARG A 1 149 ? 323.584 207.616 74.986  1.00 42.21 ? 149 ARG A CD     1 
ATOM   2152 N  NE     . ARG A 1 149 ? 322.698 208.351 74.095  1.00 47.83 ? 149 ARG A NE     1 
ATOM   2153 C  CZ     . ARG A 1 149 ? 321.595 207.857 73.551  1.00 50.89 ? 149 ARG A CZ     1 
ATOM   2154 N  NH1    . ARG A 1 149 ? 321.212 206.610 73.766  1.00 49.38 ? 149 ARG A NH1    1 
ATOM   2155 N  NH2    . ARG A 1 149 ? 320.857 208.637 72.767  1.00 53.77 ? 149 ARG A NH2    1 
ATOM   2156 H  H      . ARG A 1 149 ? 322.139 207.295 78.901  1.00 34.81 ? 149 ARG A H      1 
ATOM   2157 H  HA     . ARG A 1 149 ? 324.720 207.936 79.363  1.00 33.28 ? 149 ARG A HA     1 
ATOM   2158 H  HB2    . ARG A 1 149 ? 324.850 208.670 77.088  1.00 36.45 ? 149 ARG A HB2    1 
ATOM   2159 H  HB3    . ARG A 1 149 ? 324.876 207.094 77.279  1.00 34.96 ? 149 ARG A HB3    1 
ATOM   2160 H  HG2    . ARG A 1 149 ? 322.641 206.990 76.660  1.00 37.73 ? 149 ARG A HG2    1 
ATOM   2161 H  HG3    . ARG A 1 149 ? 322.618 208.567 76.490  1.00 38.97 ? 149 ARG A HG3    1 
ATOM   2162 H  HD2    . ARG A 1 149 ? 324.478 207.966 74.882  1.00 41.66 ? 149 ARG A HD2    1 
ATOM   2163 H  HD3    . ARG A 1 149 ? 323.565 206.679 74.741  1.00 41.97 ? 149 ARG A HD3    1 
ATOM   2164 H  HE     . ARG A 1 149 ? 322.805 209.200 74.052  1.00 47.69 ? 149 ARG A HE     1 
ATOM   2165 H  HH11   . ARG A 1 149 ? 321.676 206.094 74.270  1.00 47.45 ? 149 ARG A HH11   1 
ATOM   2166 H  HH12   . ARG A 1 149 ? 320.494 206.319 73.395  1.00 49.16 ? 149 ARG A HH12   1 
ATOM   2167 H  HH21   . ARG A 1 149 ? 321.100 209.447 72.623  1.00 51.76 ? 149 ARG A HH21   1 
ATOM   2168 H  HH22   . ARG A 1 149 ? 320.139 208.331 72.405  1.00 53.45 ? 149 ARG A HH22   1 
ATOM   2169 N  N      . ASN A 1 150 ? 322.169 209.752 79.073  1.00 35.46 ? 150 ASN A N      1 
ATOM   2170 C  CA     . ASN A 1 150 ? 321.630 211.096 79.216  1.00 36.10 ? 150 ASN A CA     1 
ATOM   2171 C  C      . ASN A 1 150 ? 321.247 211.399 80.657  1.00 39.19 ? 150 ASN A C      1 
ATOM   2172 O  O      . ASN A 1 150 ? 320.608 212.421 80.925  1.00 40.33 ? 150 ASN A O      1 
ATOM   2173 C  CB     . ASN A 1 150 ? 320.421 211.275 78.295  1.00 37.88 ? 150 ASN A CB     1 
ATOM   2174 C  CG     . ASN A 1 150 ? 319.329 210.265 78.567  1.00 42.84 ? 150 ASN A CG     1 
ATOM   2175 O  OD1    . ASN A 1 150 ? 319.587 209.069 78.678  1.00 41.43 ? 150 ASN A OD1    1 
ATOM   2176 N  ND2    . ASN A 1 150 ? 318.097 210.742 78.668  1.00 44.21 ? 150 ASN A ND2    1 
ATOM   2177 H  H      . ASN A 1 150 ? 321.569 209.144 79.013  1.00 36.62 ? 150 ASN A H      1 
ATOM   2178 H  HA     . ASN A 1 150 ? 322.308 211.731 78.957  1.00 36.14 ? 150 ASN A HA     1 
ATOM   2179 H  HB2    . ASN A 1 150 ? 320.058 212.162 78.425  1.00 39.08 ? 150 ASN A HB2    1 
ATOM   2180 H  HB3    . ASN A 1 150 ? 320.705 211.163 77.377  1.00 37.67 ? 150 ASN A HB3    1 
ATOM   2181 H  HD21   . ASN A 1 150 ? 317.955 211.586 78.585  1.00 44.07 ? 150 ASN A HD21   1 
ATOM   2182 H  HD22   . ASN A 1 150 ? 317.443 210.206 78.819  1.00 42.62 ? 150 ASN A HD22   1 
ATOM   2183 N  N      . ARG A 1 151 ? 321.657 210.553 81.594  1.00 37.22 ? 151 ARG A N      1 
ATOM   2184 C  CA     . ARG A 1 151 ? 321.037 210.479 82.903  1.00 32.51 ? 151 ARG A CA     1 
ATOM   2185 C  C      . ARG A 1 151 ? 322.052 209.938 83.894  1.00 29.96 ? 151 ARG A C      1 
ATOM   2186 O  O      . ARG A 1 151 ? 322.849 209.063 83.539  1.00 34.68 ? 151 ARG A O      1 
ATOM   2187 C  CB     . ARG A 1 151 ? 319.807 209.563 82.860  1.00 36.09 ? 151 ARG A CB     1 
ATOM   2188 C  CG     . ARG A 1 151 ? 318.887 209.656 84.037  1.00 36.25 ? 151 ARG A CG     1 
ATOM   2189 C  CD     . ARG A 1 151 ? 317.639 208.825 83.813  1.00 37.16 ? 151 ARG A CD     1 
ATOM   2190 N  NE     . ARG A 1 151 ? 317.103 208.938 82.466  1.00 38.05 ? 151 ARG A NE     1 
ATOM   2191 C  CZ     . ARG A 1 151 ? 316.334 209.932 82.055  1.00 40.72 ? 151 ARG A CZ     1 
ATOM   2192 N  NH1    . ARG A 1 151 ? 316.008 210.926 82.857  1.00 40.07 ? 151 ARG A NH1    1 
ATOM   2193 N  NH2    . ARG A 1 151 ? 315.877 209.925 80.809  1.00 43.62 ? 151 ARG A NH2    1 
ATOM   2194 H  H      . ARG A 1 151 ? 322.315 210.014 81.495  1.00 35.80 ? 151 ARG A H      1 
ATOM   2195 H  HA     . ARG A 1 151 ? 320.754 211.366 83.168  1.00 33.99 ? 151 ARG A HA     1 
ATOM   2196 H  HB2    . ARG A 1 151 ? 319.296 209.793 82.078  1.00 37.82 ? 151 ARG A HB2    1 
ATOM   2197 H  HB3    . ARG A 1 151 ? 320.109 208.646 82.798  1.00 35.61 ? 151 ARG A HB3    1 
ATOM   2198 H  HG2    . ARG A 1 151 ? 319.344 209.311 84.811  1.00 35.56 ? 151 ARG A HG2    1 
ATOM   2199 H  HG3    . ARG A 1 151 ? 318.631 210.578 84.173  1.00 37.33 ? 151 ARG A HG3    1 
ATOM   2200 H  HD2    . ARG A 1 151 ? 317.873 207.899 83.962  1.00 34.84 ? 151 ARG A HD2    1 
ATOM   2201 H  HD3    . ARG A 1 151 ? 316.937 209.094 84.420  1.00 36.90 ? 151 ARG A HD3    1 
ATOM   2202 H  HE     . ARG A 1 151 ? 317.428 208.418 81.870  1.00 37.62 ? 151 ARG A HE     1 
ATOM   2203 H  HH11   . ARG A 1 151 ? 316.299 210.931 83.665  1.00 40.56 ? 151 ARG A HH11   1 
ATOM   2204 H  HH12   . ARG A 1 151 ? 315.512 211.562 82.570  1.00 43.80 ? 151 ARG A HH12   1 
ATOM   2205 H  HH21   . ARG A 1 151 ? 316.084 209.277 80.288  1.00 41.69 ? 151 ARG A HH21   1 
ATOM   2206 H  HH22   . ARG A 1 151 ? 315.379 210.565 80.528  1.00 43.86 ? 151 ARG A HH22   1 
ATOM   2207 N  N      . PRO A 1 152 ? 322.061 210.437 85.129  1.00 28.14 ? 152 PRO A N      1 
ATOM   2208 C  CA     . PRO A 1 152 ? 322.750 209.720 86.209  1.00 28.39 ? 152 PRO A CA     1 
ATOM   2209 C  C      . PRO A 1 152 ? 321.938 208.519 86.668  1.00 28.77 ? 152 PRO A C      1 
ATOM   2210 O  O      . PRO A 1 152 ? 320.707 208.548 86.664  1.00 33.39 ? 152 PRO A O      1 
ATOM   2211 C  CB     . PRO A 1 152 ? 322.864 210.770 87.314  1.00 25.61 ? 152 PRO A CB     1 
ATOM   2212 C  CG     . PRO A 1 152 ? 321.816 211.736 87.028  1.00 28.44 ? 152 PRO A CG     1 
ATOM   2213 C  CD     . PRO A 1 152 ? 321.660 211.784 85.552  1.00 31.25 ? 152 PRO A CD     1 
ATOM   2214 H  HA     . PRO A 1 152 ? 323.633 209.442 85.931  1.00 29.47 ? 152 PRO A HA     1 
ATOM   2215 H  HB2    . PRO A 1 152 ? 322.708 210.351 88.167  1.00 27.13 ? 152 PRO A HB2    1 
ATOM   2216 H  HB3    . PRO A 1 152 ? 323.735 211.184 87.275  1.00 27.16 ? 152 PRO A HB3    1 
ATOM   2217 H  HG2    . PRO A 1 152 ? 320.999 211.449 87.452  1.00 30.55 ? 152 PRO A HG2    1 
ATOM   2218 H  HG3    . PRO A 1 152 ? 322.086 212.602 87.359  1.00 27.74 ? 152 PRO A HG3    1 
ATOM   2219 H  HD2    . PRO A 1 152 ? 320.742 211.958 85.303  1.00 32.75 ? 152 PRO A HD2    1 
ATOM   2220 H  HD3    . PRO A 1 152 ? 322.263 212.442 85.187  1.00 31.22 ? 152 PRO A HD3    1 
ATOM   2221 N  N      . TRP A 1 153 ? 322.630 207.467 87.096  1.00 25.93 ? 153 TRP A N      1 
ATOM   2222 C  CA     . TRP A 1 153 ? 321.958 206.251 87.513  1.00 23.51 ? 153 TRP A CA     1 
ATOM   2223 C  C      . TRP A 1 153 ? 322.770 205.532 88.580  1.00 25.16 ? 153 TRP A C      1 
ATOM   2224 O  O      . TRP A 1 153 ? 323.966 205.771 88.754  1.00 27.87 ? 153 TRP A O      1 
ATOM   2225 C  CB     . TRP A 1 153 ? 321.691 205.317 86.327  1.00 23.23 ? 153 TRP A CB     1 
ATOM   2226 C  CG     . TRP A 1 153 ? 322.888 204.702 85.705  1.00 24.69 ? 153 TRP A CG     1 
ATOM   2227 C  CD1    . TRP A 1 153 ? 323.656 205.227 84.719  1.00 27.48 ? 153 TRP A CD1    1 
ATOM   2228 C  CD2    . TRP A 1 153 ? 323.441 203.422 86.005  1.00 24.43 ? 153 TRP A CD2    1 
ATOM   2229 N  NE1    . TRP A 1 153 ? 324.663 204.361 84.392  1.00 30.26 ? 153 TRP A NE1    1 
ATOM   2230 C  CE2    . TRP A 1 153 ? 324.552 203.243 85.171  1.00 27.39 ? 153 TRP A CE2    1 
ATOM   2231 C  CE3    . TRP A 1 153 ? 323.109 202.413 86.905  1.00 25.18 ? 153 TRP A CE3    1 
ATOM   2232 C  CZ2    . TRP A 1 153 ? 325.328 202.100 85.212  1.00 30.22 ? 153 TRP A CZ2    1 
ATOM   2233 C  CZ3    . TRP A 1 153 ? 323.880 201.285 86.941  1.00 23.45 ? 153 TRP A CZ3    1 
ATOM   2234 C  CH2    . TRP A 1 153 ? 324.976 201.134 86.104  1.00 27.64 ? 153 TRP A CH2    1 
ATOM   2235 H  H      . TRP A 1 153 ? 323.482 207.432 87.169  1.00 26.91 ? 153 TRP A H      1 
ATOM   2236 H  HA     . TRP A 1 153 ? 321.111 206.498 87.896  1.00 25.77 ? 153 TRP A HA     1 
ATOM   2237 H  HB2    . TRP A 1 153 ? 321.119 204.599 86.626  1.00 25.02 ? 153 TRP A HB2    1 
ATOM   2238 H  HB3    . TRP A 1 153 ? 321.247 205.827 85.641  1.00 26.37 ? 153 TRP A HB3    1 
ATOM   2239 H  HD1    . TRP A 1 153 ? 323.519 206.053 84.324  1.00 28.13 ? 153 TRP A HD1    1 
ATOM   2240 H  HE1    . TRP A 1 153 ? 325.265 204.497 83.797  1.00 30.21 ? 153 TRP A HE1    1 
ATOM   2241 H  HE3    . TRP A 1 153 ? 322.380 202.507 87.468  1.00 26.00 ? 153 TRP A HE3    1 
ATOM   2242 H  HZ2    . TRP A 1 153 ? 326.062 201.994 84.654  1.00 31.60 ? 153 TRP A HZ2    1 
ATOM   2243 H  HZ3    . TRP A 1 153 ? 323.667 200.611 87.535  1.00 25.24 ? 153 TRP A HZ3    1 
ATOM   2244 H  HH2    . TRP A 1 153 ? 325.478 200.357 86.153  1.00 30.56 ? 153 TRP A HH2    1 
ATOM   2245 N  N      . PHE A 1 154 ? 322.090 204.636 89.292  1.00 22.23 ? 154 PHE A N      1 
ATOM   2246 C  CA     . PHE A 1 154 ? 322.661 203.929 90.426  1.00 21.27 ? 154 PHE A CA     1 
ATOM   2247 C  C      . PHE A 1 154 ? 321.757 202.760 90.766  1.00 23.63 ? 154 PHE A C      1 
ATOM   2248 O  O      . PHE A 1 154 ? 320.539 202.839 90.602  1.00 30.54 ? 154 PHE A O      1 
ATOM   2249 C  CB     . PHE A 1 154 ? 322.816 204.859 91.621  1.00 26.11 ? 154 PHE A CB     1 
ATOM   2250 C  CG     . PHE A 1 154 ? 323.570 204.270 92.768  1.00 26.95 ? 154 PHE A CG     1 
ATOM   2251 C  CD1    . PHE A 1 154 ? 324.940 204.150 92.728  1.00 24.87 ? 154 PHE A CD1    1 
ATOM   2252 C  CD2    . PHE A 1 154 ? 322.910 203.868 93.905  1.00 25.59 ? 154 PHE A CD2    1 
ATOM   2253 C  CE1    . PHE A 1 154 ? 325.625 203.623 93.783  1.00 20.28 ? 154 PHE A CE1    1 
ATOM   2254 C  CE2    . PHE A 1 154 ? 323.599 203.341 94.961  1.00 26.11 ? 154 PHE A CE2    1 
ATOM   2255 C  CZ     . PHE A 1 154 ? 324.955 203.221 94.898  1.00 23.16 ? 154 PHE A CZ     1 
ATOM   2256 H  H      . PHE A 1 154 ? 321.278 204.417 89.133  1.00 24.37 ? 154 PHE A H      1 
ATOM   2257 H  HA     . PHE A 1 154 ? 323.529 203.586 90.198  1.00 23.49 ? 154 PHE A HA     1 
ATOM   2258 H  HB2    . PHE A 1 154 ? 323.278 205.657 91.329  1.00 26.23 ? 154 PHE A HB2    1 
ATOM   2259 H  HB3    . PHE A 1 154 ? 321.933 205.072 91.942  1.00 25.38 ? 154 PHE A HB3    1 
ATOM   2260 H  HD1    . PHE A 1 154 ? 325.401 204.420 91.972  1.00 24.87 ? 154 PHE A HD1    1 
ATOM   2261 H  HD2    . PHE A 1 154 ? 321.986 203.949 93.951  1.00 24.83 ? 154 PHE A HD2    1 
ATOM   2262 H  HE1    . PHE A 1 154 ? 326.547 203.541 93.742  1.00 20.75 ? 154 PHE A HE1    1 
ATOM   2263 H  HE2    . PHE A 1 154 ? 323.145 203.068 95.721  1.00 25.41 ? 154 PHE A HE2    1 
ATOM   2264 H  HZ     . PHE A 1 154 ? 325.420 202.863 95.614  1.00 23.05 ? 154 PHE A HZ     1 
ATOM   2265 N  N      . ILE A 1 155 ? 322.364 201.677 91.231  1.00 23.04 ? 155 ILE A N      1 
ATOM   2266 C  CA     . ILE A 1 155 ? 321.647 200.461 91.586  1.00 23.07 ? 155 ILE A CA     1 
ATOM   2267 C  C      . ILE A 1 155 ? 322.100 200.002 92.963  1.00 24.68 ? 155 ILE A C      1 
ATOM   2268 O  O      . ILE A 1 155 ? 323.302 199.919 93.239  1.00 25.32 ? 155 ILE A O      1 
ATOM   2269 C  CB     . ILE A 1 155 ? 321.857 199.351 90.543  1.00 23.44 ? 155 ILE A CB     1 
ATOM   2270 C  CG1    . ILE A 1 155 ? 321.138 198.088 90.979  1.00 25.44 ? 155 ILE A CG1    1 
ATOM   2271 C  CG2    . ILE A 1 155 ? 323.314 199.083 90.348  1.00 26.97 ? 155 ILE A CG2    1 
ATOM   2272 C  CD1    . ILE A 1 155 ? 320.544 197.341 89.872  1.00 23.65 ? 155 ILE A CD1    1 
ATOM   2273 H  H      . ILE A 1 155 ? 323.209 201.618 91.343  1.00 24.14 ? 155 ILE A H      1 
ATOM   2274 H  HA     . ILE A 1 155 ? 320.703 200.651 91.634  1.00 24.46 ? 155 ILE A HA     1 
ATOM   2275 H  HB     . ILE A 1 155 ? 321.483 199.634 89.702  1.00 24.33 ? 155 ILE A HB     1 
ATOM   2276 H  HG12   . ILE A 1 155 ? 321.773 197.508 91.416  1.00 26.92 ? 155 ILE A HG12   1 
ATOM   2277 H  HG13   . ILE A 1 155 ? 320.428 198.328 91.585  1.00 26.01 ? 155 ILE A HG13   1 
ATOM   2278 H  HG21   . ILE A 1 155 ? 323.409 198.471 89.603  1.00 27.93 ? 155 ILE A HG21   1 
ATOM   2279 H  HG22   . ILE A 1 155 ? 323.670 198.687 91.155  1.00 26.81 ? 155 ILE A HG22   1 
ATOM   2280 H  HG23   . ILE A 1 155 ? 323.765 199.918 90.158  1.00 25.90 ? 155 ILE A HG23   1 
ATOM   2281 H  HD11   . ILE A 1 155 ? 319.993 196.633 90.230  1.00 27.34 ? 155 ILE A HD11   1 
ATOM   2282 H  HD12   . ILE A 1 155 ? 321.260 196.978 89.336  1.00 27.60 ? 155 ILE A HD12   1 
ATOM   2283 H  HD13   . ILE A 1 155 ? 320.003 197.946 89.349  1.00 25.87 ? 155 ILE A HD13   1 
ATOM   2284 N  N      . GLN A 1 156 ? 321.131 199.699 93.820  1.00 24.96 ? 156 GLN A N      1 
ATOM   2285 C  CA     . GLN A 1 156 ? 321.374 199.317 95.198  1.00 28.09 ? 156 GLN A CA     1 
ATOM   2286 C  C      . GLN A 1 156 ? 320.593 198.048 95.508  1.00 32.56 ? 156 GLN A C      1 
ATOM   2287 O  O      . GLN A 1 156 ? 319.469 197.871 95.032  1.00 35.86 ? 156 GLN A O      1 
ATOM   2288 C  CB     . GLN A 1 156 ? 320.956 200.441 96.137  1.00 26.94 ? 156 GLN A CB     1 
ATOM   2289 C  CG     . GLN A 1 156 ? 321.311 200.238 97.587  1.00 30.70 ? 156 GLN A CG     1 
ATOM   2290 C  CD     . GLN A 1 156 ? 322.780 200.404 97.864  1.00 36.43 ? 156 GLN A CD     1 
ATOM   2291 O  OE1    . GLN A 1 156 ? 323.397 201.389 97.470  1.00 40.52 ? 156 GLN A OE1    1 
ATOM   2292 N  NE2    . GLN A 1 156 ? 323.347 199.444 98.565  1.00 32.68 ? 156 GLN A NE2    1 
ATOM   2293 H  H      . GLN A 1 156 ? 320.299 199.716 93.625  1.00 26.48 ? 156 GLN A H      1 
ATOM   2294 H  HA     . GLN A 1 156 ? 322.314 199.140 95.319  1.00 28.52 ? 156 GLN A HA     1 
ATOM   2295 H  HB2    . GLN A 1 156 ? 321.370 201.262 95.842  1.00 28.39 ? 156 GLN A HB2    1 
ATOM   2296 H  HB3    . GLN A 1 156 ? 319.998 200.523 96.088  1.00 26.96 ? 156 GLN A HB3    1 
ATOM   2297 H  HG2    . GLN A 1 156 ? 320.829 200.882 98.120  1.00 30.27 ? 156 GLN A HG2    1 
ATOM   2298 H  HG3    . GLN A 1 156 ? 321.066 199.340 97.846  1.00 30.76 ? 156 GLN A HG3    1 
ATOM   2299 H  HE21   . GLN A 1 156 ? 322.865 198.783 98.816  1.00 32.03 ? 156 GLN A HE21   1 
ATOM   2300 H  HE22   . GLN A 1 156 ? 324.182 199.475 98.762  1.00 32.94 ? 156 GLN A HE22   1 
ATOM   2301 N  N      . ALA A 1 157 ? 321.197 197.164 96.294  1.00 30.79 ? 157 ALA A N      1 
ATOM   2302 C  CA     . ALA A 1 157 ? 320.573 195.916 96.702  1.00 29.62 ? 157 ALA A CA     1 
ATOM   2303 C  C      . ALA A 1 157 ? 319.922 196.092 98.062  1.00 32.43 ? 157 ALA A C      1 
ATOM   2304 O  O      . ALA A 1 157 ? 320.574 196.536 99.011  1.00 37.56 ? 157 ALA A O      1 
ATOM   2305 C  CB     . ALA A 1 157 ? 321.598 194.794 96.763  1.00 33.42 ? 157 ALA A CB     1 
ATOM   2306 H  H      . ALA A 1 157 ? 321.988 197.262 96.606  1.00 30.95 ? 157 ALA A H      1 
ATOM   2307 H  HA     . ALA A 1 157 ? 319.894 195.674 96.064  1.00 31.80 ? 157 ALA A HA     1 
ATOM   2308 H  HB1    . ALA A 1 157 ? 322.030 194.729 95.900  1.00 34.13 ? 157 ALA A HB1    1 
ATOM   2309 H  HB2    . ALA A 1 157 ? 321.133 193.971 96.970  1.00 34.40 ? 157 ALA A HB2    1 
ATOM   2310 H  HB3    . ALA A 1 157 ? 322.245 195.005 97.447  1.00 34.13 ? 157 ALA A HB3    1 
ATOM   2311 N  N      . THR A 1 158 ? 318.656 195.697 98.167  1.00 33.44 ? 158 THR A N      1 
ATOM   2312 C  CA     . THR A 1 158 ? 317.833 196.040 99.310  1.00 34.20 ? 158 THR A CA     1 
ATOM   2313 C  C      . THR A 1 158 ? 317.152 194.804 99.889  1.00 37.35 ? 158 THR A C      1 
ATOM   2314 O  O      . THR A 1 158 ? 317.289 193.684 99.395  1.00 40.48 ? 158 THR A O      1 
ATOM   2315 C  CB     . THR A 1 158 ? 316.775 197.075 98.918  1.00 34.02 ? 158 THR A CB     1 
ATOM   2316 O  OG1    . THR A 1 158 ? 315.868 196.506 97.974  1.00 36.86 ? 158 THR A OG1    1 
ATOM   2317 C  CG2    . THR A 1 158 ? 317.431 198.251 98.267  1.00 31.83 ? 158 THR A CG2    1 
ATOM   2318 H  H      . THR A 1 158 ? 318.250 195.231 97.578  1.00 34.23 ? 158 THR A H      1 
ATOM   2319 H  HA     . THR A 1 158 ? 318.392 196.435 99.992  1.00 34.15 ? 158 THR A HA     1 
ATOM   2320 H  HB     . THR A 1 158 ? 316.286 197.384 99.693  1.00 34.16 ? 158 THR A HB     1 
ATOM   2321 H  HG1    . THR A 1 158 ? 315.219 197.027 97.868  1.00 34.68 ? 158 THR A HG1    1 
ATOM   2322 H  HG21   . THR A 1 158 ? 318.032 198.688 98.886  1.00 31.63 ? 158 THR A HG21   1 
ATOM   2323 H  HG22   . THR A 1 158 ? 316.760 198.879 97.970  1.00 30.32 ? 158 THR A HG22   1 
ATOM   2324 H  HG23   . THR A 1 158 ? 317.934 197.947 97.501  1.00 31.99 ? 158 THR A HG23   1 
ATOM   2325 N  N      . CYS A 1 159 ? 316.414 195.048 100.969 1.00 36.08 ? 159 CYS A N      1 
ATOM   2326 C  CA     . CYS A 1 159 ? 315.574 194.082 101.678 1.00 33.00 ? 159 CYS A CA     1 
ATOM   2327 C  C      . CYS A 1 159 ? 314.637 194.930 102.539 1.00 35.26 ? 159 CYS A C      1 
ATOM   2328 O  O      . CYS A 1 159 ? 314.922 195.201 103.705 1.00 38.24 ? 159 CYS A O      1 
ATOM   2329 C  CB     . CYS A 1 159 ? 316.370 193.096 102.520 1.00 34.77 ? 159 CYS A CB     1 
ATOM   2330 S  SG     . CYS A 1 159 ? 315.343 191.928 103.420 1.00 51.99 ? 159 CYS A SG     1 
ATOM   2331 H  H      . CYS A 1 159 ? 316.377 195.820 101.330 1.00 35.93 ? 159 CYS A H      1 
ATOM   2332 H  HA     . CYS A 1 159 ? 315.045 193.576 101.049 1.00 36.10 ? 159 CYS A HA     1 
ATOM   2333 H  HB2    . CYS A 1 159 ? 316.957 192.589 101.945 1.00 38.08 ? 159 CYS A HB2    1 
ATOM   2334 H  HB3    . CYS A 1 159 ? 316.889 193.579 103.175 1.00 36.69 ? 159 CYS A HB3    1 
ATOM   2335 H  HG     . CYS A 1 159 ? 314.849 191.236 102.576 1.00 44.90 ? 159 CYS A HG     1 
ATOM   2336 N  N      . ALA A 1 160 ? 313.537 195.366 101.930 1.00 34.73 ? 160 ALA A N      1 
ATOM   2337 C  CA     . ALA A 1 160 ? 312.616 196.279 102.598 1.00 33.28 ? 160 ALA A CA     1 
ATOM   2338 C  C      . ALA A 1 160 ? 312.109 195.718 103.914 1.00 38.83 ? 160 ALA A C      1 
ATOM   2339 O  O      . ALA A 1 160 ? 311.773 196.484 104.823 1.00 43.07 ? 160 ALA A O      1 
ATOM   2340 C  CB     . ALA A 1 160 ? 311.439 196.585 101.687 1.00 29.88 ? 160 ALA A CB     1 
ATOM   2341 H  H      . ALA A 1 160 ? 313.324 195.173 101.127 1.00 35.02 ? 160 ALA A H      1 
ATOM   2342 H  HA     . ALA A 1 160 ? 313.076 197.107 102.775 1.00 34.38 ? 160 ALA A HA     1 
ATOM   2343 H  HB1    . ALA A 1 160 ? 310.926 195.772 101.573 1.00 31.12 ? 160 ALA A HB1    1 
ATOM   2344 H  HB2    . ALA A 1 160 ? 311.772 196.902 100.837 1.00 32.19 ? 160 ALA A HB2    1 
ATOM   2345 H  HB3    . ALA A 1 160 ? 310.895 197.261 102.110 1.00 31.22 ? 160 ALA A HB3    1 
ATOM   2346 N  N      . THR A 1 161 ? 312.030 194.395 104.038 1.00 38.40 ? 161 THR A N      1 
ATOM   2347 C  CA     . THR A 1 161 ? 311.586 193.809 105.292 1.00 36.56 ? 161 THR A CA     1 
ATOM   2348 C  C      . THR A 1 161 ? 312.583 194.057 106.415 1.00 39.42 ? 161 THR A C      1 
ATOM   2349 O  O      . THR A 1 161 ? 312.188 194.133 107.583 1.00 43.06 ? 161 THR A O      1 
ATOM   2350 C  CB     . THR A 1 161 ? 311.348 192.316 105.113 1.00 35.93 ? 161 THR A CB     1 
ATOM   2351 O  OG1    . THR A 1 161 ? 312.548 191.691 104.647 1.00 36.52 ? 161 THR A OG1    1 
ATOM   2352 C  CG2    . THR A 1 161 ? 310.255 192.088 104.118 1.00 34.92 ? 161 THR A CG2    1 
ATOM   2353 H  H      . THR A 1 161 ? 312.212 193.827 103.423 1.00 38.25 ? 161 THR A H      1 
ATOM   2354 H  HA     . THR A 1 161 ? 310.747 194.212 105.533 1.00 37.44 ? 161 THR A HA     1 
ATOM   2355 H  HB     . THR A 1 161 ? 311.079 191.924 105.956 1.00 37.87 ? 161 THR A HB     1 
ATOM   2356 H  HG1    . THR A 1 161 ? 313.188 191.906 105.145 1.00 37.54 ? 161 THR A HG1    1 
ATOM   2357 H  HG21   . THR A 1 161 ? 309.530 192.708 104.283 1.00 35.10 ? 161 THR A HG21   1 
ATOM   2358 H  HG22   . THR A 1 161 ? 310.595 192.235 103.224 1.00 36.73 ? 161 THR A HG22   1 
ATOM   2359 H  HG23   . THR A 1 161 ? 309.928 191.181 104.190 1.00 35.96 ? 161 THR A HG23   1 
ATOM   2360 N  N      . SER A 1 162 ? 313.866 194.191 106.088 1.00 35.04 ? 162 SER A N      1 
ATOM   2361 C  CA     . SER A 1 162 ? 314.903 194.452 107.075 1.00 37.41 ? 162 SER A CA     1 
ATOM   2362 C  C      . SER A 1 162 ? 315.473 195.859 106.994 1.00 38.54 ? 162 SER A C      1 
ATOM   2363 O  O      . SER A 1 162 ? 316.278 196.233 107.852 1.00 41.19 ? 162 SER A O      1 
ATOM   2364 C  CB     . SER A 1 162 ? 316.041 193.444 106.913 1.00 37.10 ? 162 SER A CB     1 
ATOM   2365 O  OG     . SER A 1 162 ? 316.496 193.405 105.576 1.00 42.77 ? 162 SER A OG     1 
ATOM   2366 H  H      . SER A 1 162 ? 314.165 194.131 105.288 1.00 37.21 ? 162 SER A H      1 
ATOM   2367 H  HA     . SER A 1 162 ? 314.532 194.332 107.956 1.00 38.50 ? 162 SER A HA     1 
ATOM   2368 H  HB2    . SER A 1 162 ? 316.770 193.701 107.496 1.00 37.84 ? 162 SER A HB2    1 
ATOM   2369 H  HB3    . SER A 1 162 ? 315.719 192.564 107.151 1.00 37.94 ? 162 SER A HB3    1 
ATOM   2370 H  HG     . SER A 1 162 ? 317.001 192.743 105.469 1.00 40.64 ? 162 SER A HG     1 
ATOM   2371 N  N      . GLY A 1 163 ? 315.088 196.640 105.993 1.00 39.09 ? 163 GLY A N      1 
ATOM   2372 C  CA     . GLY A 1 163 ? 315.565 197.996 105.852 1.00 36.73 ? 163 GLY A CA     1 
ATOM   2373 C  C      . GLY A 1 163 ? 316.928 198.138 105.219 1.00 34.31 ? 163 GLY A C      1 
ATOM   2374 O  O      . GLY A 1 163 ? 317.394 199.270 105.047 1.00 36.19 ? 163 GLY A O      1 
ATOM   2375 H  H      . GLY A 1 163 ? 314.539 196.396 105.382 1.00 38.22 ? 163 GLY A H      1 
ATOM   2376 H  HA2    . GLY A 1 163 ? 314.937 198.497 105.319 1.00 36.49 ? 163 GLY A HA2    1 
ATOM   2377 H  HA3    . GLY A 1 163 ? 315.606 198.402 106.729 1.00 37.17 ? 163 GLY A HA3    1 
ATOM   2378 N  N      . GLU A 1 164 ? 317.585 197.037 104.870 1.00 33.22 ? 164 GLU A N      1 
ATOM   2379 C  CA     . GLU A 1 164 ? 318.920 197.115 104.299 1.00 34.78 ? 164 GLU A CA     1 
ATOM   2380 C  C      . GLU A 1 164 ? 318.881 197.792 102.939 1.00 37.15 ? 164 GLU A C      1 
ATOM   2381 O  O      . GLU A 1 164 ? 318.031 197.484 102.101 1.00 37.56 ? 164 GLU A O      1 
ATOM   2382 C  CB     . GLU A 1 164 ? 319.524 195.722 104.179 1.00 30.46 ? 164 GLU A CB     1 
ATOM   2383 H  H      . GLU A 1 164 ? 317.287 196.240 104.961 1.00 35.24 ? 164 GLU A H      1 
ATOM   2384 H  HA     . GLU A 1 164 ? 319.485 197.638 104.878 1.00 35.58 ? 164 GLU A HA     1 
ATOM   2385 H  HB2    . GLU A 1 164 ? 318.840 195.111 103.880 1.00 34.04 ? 164 GLU A HB2    1 
ATOM   2386 H  HB3    . GLU A 1 164 ? 320.246 195.749 103.534 1.00 31.70 ? 164 GLU A HB3    1 
ATOM   2387 N  N      . GLY A 1 165 ? 319.804 198.723 102.728 1.00 38.06 ? 165 GLY A N      1 
ATOM   2388 C  CA     . GLY A 1 165 ? 319.974 199.369 101.447 1.00 35.47 ? 165 GLY A CA     1 
ATOM   2389 C  C      . GLY A 1 165 ? 318.982 200.458 101.124 1.00 36.15 ? 165 GLY A C      1 
ATOM   2390 O  O      . GLY A 1 165 ? 319.065 201.044 100.041 1.00 41.22 ? 165 GLY A O      1 
ATOM   2391 H  H      . GLY A 1 165 ? 320.345 198.999 103.330 1.00 37.27 ? 165 GLY A H      1 
ATOM   2392 H  HA2    . GLY A 1 165 ? 320.859 199.759 101.406 1.00 35.83 ? 165 GLY A HA2    1 
ATOM   2393 H  HA3    . GLY A 1 165 ? 319.902 198.697 100.760 1.00 35.30 ? 165 GLY A HA3    1 
ATOM   2394 N  N      . LEU A 1 166 ? 318.043 200.744 102.015 1.00 31.66 ? 166 LEU A N      1 
ATOM   2395 C  CA     . LEU A 1 166 ? 317.022 201.754 101.785 1.00 31.53 ? 166 LEU A CA     1 
ATOM   2396 C  C      . LEU A 1 166 ? 317.491 203.165 102.087 1.00 34.79 ? 166 LEU A C      1 
ATOM   2397 O  O      . LEU A 1 166 ? 317.209 204.077 101.304 1.00 37.03 ? 166 LEU A O      1 
ATOM   2398 C  CB     . LEU A 1 166 ? 315.787 201.437 102.624 1.00 31.08 ? 166 LEU A CB     1 
ATOM   2399 C  CG     . LEU A 1 166 ? 314.677 200.703 101.888 1.00 31.82 ? 166 LEU A CG     1 
ATOM   2400 C  CD1    . LEU A 1 166 ? 315.113 199.366 101.455 1.00 34.57 ? 166 LEU A CD1    1 
ATOM   2401 C  CD2    . LEU A 1 166 ? 313.498 200.571 102.791 1.00 33.58 ? 166 LEU A CD2    1 
ATOM   2402 H  H      . LEU A 1 166 ? 317.984 200.358 102.774 1.00 33.44 ? 166 LEU A H      1 
ATOM   2403 H  HA     . LEU A 1 166 ? 316.751 201.728 100.862 1.00 32.57 ? 166 LEU A HA     1 
ATOM   2404 H  HB2    . LEU A 1 166 ? 316.079 200.858 103.341 1.00 32.92 ? 166 LEU A HB2    1 
ATOM   2405 H  HB3    . LEU A 1 166 ? 315.416 202.248 102.992 1.00 32.10 ? 166 LEU A HB3    1 
ATOM   2406 H  HG     . LEU A 1 166 ? 314.431 201.207 101.105 1.00 31.54 ? 166 LEU A HG     1 
ATOM   2407 H  HD11   . LEU A 1 166 ? 314.458 198.979 100.852 1.00 32.58 ? 166 LEU A HD11   1 
ATOM   2408 H  HD12   . LEU A 1 166 ? 315.194 198.835 102.256 1.00 35.31 ? 166 LEU A HD12   1 
ATOM   2409 H  HD13   . LEU A 1 166 ? 315.964 199.453 101.009 1.00 34.27 ? 166 LEU A HD13   1 
ATOM   2410 H  HD21   . LEU A 1 166 ? 313.794 200.676 103.704 1.00 33.44 ? 166 LEU A HD21   1 
ATOM   2411 H  HD22   . LEU A 1 166 ? 313.110 199.695 102.672 1.00 33.90 ? 166 LEU A HD22   1 
ATOM   2412 H  HD23   . LEU A 1 166 ? 312.858 201.255 102.563 1.00 32.87 ? 166 LEU A HD23   1 
ATOM   2413 N  N      . TYR A 1 167 ? 318.191 203.366 103.192 1.00 38.81 ? 167 TYR A N      1 
ATOM   2414 C  CA     . TYR A 1 167 ? 318.752 204.656 103.539 1.00 39.82 ? 167 TYR A CA     1 
ATOM   2415 C  C      . TYR A 1 167 ? 320.017 204.973 102.763 1.00 39.57 ? 167 TYR A C      1 
ATOM   2416 O  O      . TYR A 1 167 ? 320.530 206.089 102.881 1.00 41.01 ? 167 TYR A O      1 
ATOM   2417 C  CB     . TYR A 1 167 ? 319.045 204.707 105.041 1.00 42.08 ? 167 TYR A CB     1 
ATOM   2418 C  CG     . TYR A 1 167 ? 317.837 205.009 105.898 1.00 43.15 ? 167 TYR A CG     1 
ATOM   2419 C  CD1    . TYR A 1 167 ? 316.956 206.021 105.562 1.00 40.61 ? 167 TYR A CD1    1 
ATOM   2420 C  CD2    . TYR A 1 167 ? 317.574 204.273 107.038 1.00 46.71 ? 167 TYR A CD2    1 
ATOM   2421 C  CE1    . TYR A 1 167 ? 315.858 206.295 106.333 1.00 41.02 ? 167 TYR A CE1    1 
ATOM   2422 C  CE2    . TYR A 1 167 ? 316.476 204.541 107.819 1.00 48.36 ? 167 TYR A CE2    1 
ATOM   2423 C  CZ     . TYR A 1 167 ? 315.620 205.554 107.461 1.00 46.74 ? 167 TYR A CZ     1 
ATOM   2424 O  OH     . TYR A 1 167 ? 314.516 205.833 108.232 1.00 52.03 ? 167 TYR A OH     1 
ATOM   2425 H  H      . TYR A 1 167 ? 318.361 202.754 103.767 1.00 38.16 ? 167 TYR A H      1 
ATOM   2426 H  HA     . TYR A 1 167 ? 318.110 205.342 103.320 1.00 39.19 ? 167 TYR A HA     1 
ATOM   2427 H  HB2    . TYR A 1 167 ? 319.391 203.841 105.309 1.00 41.47 ? 167 TYR A HB2    1 
ATOM   2428 H  HB3    . TYR A 1 167 ? 319.702 205.396 105.205 1.00 41.70 ? 167 TYR A HB3    1 
ATOM   2429 H  HD1    . TYR A 1 167 ? 317.115 206.524 104.800 1.00 41.69 ? 167 TYR A HD1    1 
ATOM   2430 H  HD2    . TYR A 1 167 ? 318.151 203.589 107.282 1.00 45.63 ? 167 TYR A HD2    1 
ATOM   2431 H  HE1    . TYR A 1 167 ? 315.278 206.979 106.096 1.00 41.94 ? 167 TYR A HE1    1 
ATOM   2432 H  HE2    . TYR A 1 167 ? 316.312 204.039 108.581 1.00 48.11 ? 167 TYR A HE2    1 
ATOM   2433 H  HH     . TYR A 1 167 ? 314.509 205.341 108.911 1.00 48.72 ? 167 TYR A HH     1 
ATOM   2434 N  N      . GLU A 1 168 ? 320.550 204.013 102.016 1.00 39.89 ? 168 GLU A N      1 
ATOM   2435 C  CA     . GLU A 1 168 ? 321.670 204.235 101.118 1.00 37.45 ? 168 GLU A CA     1 
ATOM   2436 C  C      . GLU A 1 168 ? 321.223 204.666 99.731  1.00 37.45 ? 168 GLU A C      1 
ATOM   2437 O  O      . GLU A 1 168 ? 322.061 205.042 98.909  1.00 38.85 ? 168 GLU A O      1 
ATOM   2438 C  CB     . GLU A 1 168 ? 322.510 202.965 101.024 1.00 41.33 ? 168 GLU A CB     1 
ATOM   2439 C  CG     . GLU A 1 168 ? 323.222 202.603 102.304 1.00 46.87 ? 168 GLU A CG     1 
ATOM   2440 C  CD     . GLU A 1 168 ? 323.336 201.109 102.510 1.00 52.78 ? 168 GLU A CD     1 
ATOM   2441 O  OE1    . GLU A 1 168 ? 322.499 200.544 103.244 1.00 54.32 ? 168 GLU A OE1    1 
ATOM   2442 O  OE2    . GLU A 1 168 ? 324.267 200.499 101.946 1.00 54.00 ? 168 GLU A OE2    1 
ATOM   2443 H  H      . GLU A 1 168 ? 320.274 203.204 102.017 1.00 40.21 ? 168 GLU A H      1 
ATOM   2444 H  HA     . GLU A 1 168 ? 322.228 204.935 101.480 1.00 39.09 ? 168 GLU A HA     1 
ATOM   2445 H  HB2    . GLU A 1 168 ? 321.929 202.228 100.793 1.00 41.30 ? 168 GLU A HB2    1 
ATOM   2446 H  HB3    . GLU A 1 168 ? 323.179 203.087 100.338 1.00 41.21 ? 168 GLU A HB3    1 
ATOM   2447 H  HG2    . GLU A 1 168 ? 324.118 202.964 102.271 1.00 46.73 ? 168 GLU A HG2    1 
ATOM   2448 H  HG3    . GLU A 1 168 ? 322.736 202.982 103.050 1.00 44.65 ? 168 GLU A HG3    1 
ATOM   2449 N  N      . GLY A 1 169 ? 319.928 204.612 99.451  1.00 36.60 ? 169 GLY A N      1 
ATOM   2450 C  CA     . GLY A 1 169 ? 319.393 205.131 98.212  1.00 30.64 ? 169 GLY A CA     1 
ATOM   2451 C  C      . GLY A 1 169 ? 318.997 206.583 98.317  1.00 32.21 ? 169 GLY A C      1 
ATOM   2452 O  O      . GLY A 1 169 ? 319.303 207.381 97.430  1.00 36.29 ? 169 GLY A O      1 
ATOM   2453 H  H      . GLY A 1 169 ? 319.335 204.277 99.969  1.00 36.93 ? 169 GLY A H      1 
ATOM   2454 H  HA2    . GLY A 1 169 ? 320.055 205.046 97.517  1.00 31.79 ? 169 GLY A HA2    1 
ATOM   2455 H  HA3    . GLY A 1 169 ? 318.609 204.624 97.969  1.00 31.23 ? 169 GLY A HA3    1 
ATOM   2456 N  N      . LEU A 1 170 ? 318.306 206.939 99.393  1.00 31.93 ? 170 LEU A N      1 
ATOM   2457 C  CA     . LEU A 1 170 ? 318.038 208.333 99.694  1.00 32.28 ? 170 LEU A CA     1 
ATOM   2458 C  C      . LEU A 1 170 ? 319.313 209.131 99.874  1.00 34.67 ? 170 LEU A C      1 
ATOM   2459 O  O      . LEU A 1 170 ? 319.323 210.334 99.599  1.00 39.43 ? 170 LEU A O      1 
ATOM   2460 C  CB     . LEU A 1 170 ? 317.201 208.460 100.961 1.00 34.73 ? 170 LEU A CB     1 
ATOM   2461 C  CG     . LEU A 1 170 ? 315.856 207.760 101.044 1.00 34.65 ? 170 LEU A CG     1 
ATOM   2462 C  CD1    . LEU A 1 170 ? 315.227 208.116 102.352 1.00 32.49 ? 170 LEU A CD1    1 
ATOM   2463 C  CD2    . LEU A 1 170 ? 314.959 208.162 99.911  1.00 33.82 ? 170 LEU A CD2    1 
ATOM   2464 H  H      . LEU A 1 170 ? 317.980 206.391 99.961  1.00 33.98 ? 170 LEU A H      1 
ATOM   2465 H  HA     . LEU A 1 170 ? 317.544 208.725 98.964  1.00 33.04 ? 170 LEU A HA     1 
ATOM   2466 H  HB2    . LEU A 1 170 ? 317.733 208.124 101.693 1.00 35.51 ? 170 LEU A HB2    1 
ATOM   2467 H  HB3    . LEU A 1 170 ? 317.026 209.396 101.101 1.00 35.41 ? 170 LEU A HB3    1 
ATOM   2468 H  HG     . LEU A 1 170 ? 315.989 206.805 101.013 1.00 34.95 ? 170 LEU A HG     1 
ATOM   2469 H  HD11   . LEU A 1 170 ? 315.827 207.863 103.067 1.00 35.74 ? 170 LEU A HD11   1 
ATOM   2470 H  HD12   . LEU A 1 170 ? 314.385 207.648 102.434 1.00 33.91 ? 170 LEU A HD12   1 
ATOM   2471 H  HD13   . LEU A 1 170 ? 315.080 209.071 102.370 1.00 33.81 ? 170 LEU A HD13   1 
ATOM   2472 H  HD21   . LEU A 1 170 ? 314.905 209.126 99.893  1.00 34.61 ? 170 LEU A HD21   1 
ATOM   2473 H  HD22   . LEU A 1 170 ? 314.080 207.788 100.058 1.00 32.77 ? 170 LEU A HD22   1 
ATOM   2474 H  HD23   . LEU A 1 170 ? 315.328 207.832 99.081  1.00 34.00 ? 170 LEU A HD23   1 
ATOM   2475 N  N      . GLU A 1 171 ? 320.379 208.491 100.335 1.00 34.77 ? 171 GLU A N      1 
ATOM   2476 C  CA     . GLU A 1 171 ? 321.681 209.126 100.447 1.00 32.67 ? 171 GLU A CA     1 
ATOM   2477 C  C      . GLU A 1 171 ? 322.255 209.474 99.082  1.00 34.05 ? 171 GLU A C      1 
ATOM   2478 O  O      . GLU A 1 171 ? 322.855 210.538 98.918  1.00 40.49 ? 171 GLU A O      1 
ATOM   2479 C  CB     . GLU A 1 171 ? 322.635 208.205 101.203 1.00 36.34 ? 171 GLU A CB     1 
ATOM   2480 C  CG     . GLU A 1 171 ? 323.804 208.905 101.854 1.00 41.84 ? 171 GLU A CG     1 
ATOM   2481 C  CD     . GLU A 1 171 ? 323.601 209.178 103.329 1.00 48.70 ? 171 GLU A CD     1 
ATOM   2482 O  OE1    . GLU A 1 171 ? 322.713 208.552 103.939 1.00 50.44 ? 171 GLU A OE1    1 
ATOM   2483 O  OE2    . GLU A 1 171 ? 324.341 210.014 103.887 1.00 50.74 ? 171 GLU A OE2    1 
ATOM   2484 H  H      . GLU A 1 171 ? 320.369 207.676 100.596 1.00 36.41 ? 171 GLU A H      1 
ATOM   2485 H  HA     . GLU A 1 171 ? 321.593 209.945 100.947 1.00 36.48 ? 171 GLU A HA     1 
ATOM   2486 H  HB2    . GLU A 1 171 ? 322.143 207.739 101.890 1.00 39.33 ? 171 GLU A HB2    1 
ATOM   2487 H  HB3    . GLU A 1 171 ? 322.988 207.567 100.573 1.00 37.27 ? 171 GLU A HB3    1 
ATOM   2488 H  HG2    . GLU A 1 171 ? 324.590 208.347 101.766 1.00 41.79 ? 171 GLU A HG2    1 
ATOM   2489 H  HG3    . GLU A 1 171 ? 323.939 209.753 101.411 1.00 43.21 ? 171 GLU A HG3    1 
ATOM   2490 N  N      . TRP A 1 172 ? 322.069 208.596 98.094  1.00 30.09 ? 172 TRP A N      1 
ATOM   2491 C  CA     . TRP A 1 172 ? 322.548 208.880 96.747  1.00 25.97 ? 172 TRP A CA     1 
ATOM   2492 C  C      . TRP A 1 172 ? 321.696 209.930 96.057  1.00 29.36 ? 172 TRP A C      1 
ATOM   2493 O  O      . TRP A 1 172 ? 322.227 210.780 95.336  1.00 35.49 ? 172 TRP A O      1 
ATOM   2494 C  CB     . TRP A 1 172 ? 322.571 207.606 95.911  1.00 22.93 ? 172 TRP A CB     1 
ATOM   2495 C  CG     . TRP A 1 172 ? 323.030 207.833 94.517  1.00 25.77 ? 172 TRP A CG     1 
ATOM   2496 C  CD1    . TRP A 1 172 ? 324.313 207.871 94.072  1.00 23.86 ? 172 TRP A CD1    1 
ATOM   2497 C  CD2    . TRP A 1 172 ? 322.205 208.067 93.378  1.00 30.51 ? 172 TRP A CD2    1 
ATOM   2498 N  NE1    . TRP A 1 172 ? 324.339 208.116 92.724  1.00 24.63 ? 172 TRP A NE1    1 
ATOM   2499 C  CE2    . TRP A 1 172 ? 323.053 208.241 92.277  1.00 27.40 ? 172 TRP A CE2    1 
ATOM   2500 C  CE3    . TRP A 1 172 ? 320.830 208.149 93.183  1.00 28.18 ? 172 TRP A CE3    1 
ATOM   2501 C  CZ2    . TRP A 1 172 ? 322.569 208.489 91.008  1.00 24.82 ? 172 TRP A CZ2    1 
ATOM   2502 C  CZ3    . TRP A 1 172 ? 320.360 208.395 91.932  1.00 23.75 ? 172 TRP A CZ3    1 
ATOM   2503 C  CH2    . TRP A 1 172 ? 321.218 208.562 90.858  1.00 23.66 ? 172 TRP A CH2    1 
ATOM   2504 H  H      . TRP A 1 172 ? 321.678 207.841 98.178  1.00 31.80 ? 172 TRP A H      1 
ATOM   2505 H  HA     . TRP A 1 172 ? 323.446 209.220 96.795  1.00 28.83 ? 172 TRP A HA     1 
ATOM   2506 H  HB2    . TRP A 1 172 ? 323.158 206.963 96.325  1.00 26.45 ? 172 TRP A HB2    1 
ATOM   2507 H  HB3    . TRP A 1 172 ? 321.673 207.258 95.863  1.00 26.99 ? 172 TRP A HB3    1 
ATOM   2508 H  HD1    . TRP A 1 172 ? 325.062 207.751 94.601  1.00 24.84 ? 172 TRP A HD1    1 
ATOM   2509 H  HE1    . TRP A 1 172 ? 325.044 208.182 92.240  1.00 25.08 ? 172 TRP A HE1    1 
ATOM   2510 H  HE3    . TRP A 1 172 ? 320.244 208.041 93.892  1.00 28.06 ? 172 TRP A HE3    1 
ATOM   2511 H  HZ2    . TRP A 1 172 ? 323.140 208.601 90.289  1.00 25.64 ? 172 TRP A HZ2    1 
ATOM   2512 H  HZ3    . TRP A 1 172 ? 319.448 208.448 91.797  1.00 25.61 ? 172 TRP A HZ3    1 
ATOM   2513 H  HH2    . TRP A 1 172 ? 320.862 208.728 90.022  1.00 26.07 ? 172 TRP A HH2    1 
ATOM   2514 N  N      . LEU A 1 173 ? 320.388 209.888 96.254  1.00 31.11 ? 173 LEU A N      1 
ATOM   2515 C  CA     . LEU A 1 173 ? 319.489 210.876 95.693  1.00 31.01 ? 173 LEU A CA     1 
ATOM   2516 C  C      . LEU A 1 173 ? 319.822 212.281 96.147  1.00 33.71 ? 173 LEU A C      1 
ATOM   2517 O  O      . LEU A 1 173 ? 319.542 213.240 95.422  1.00 39.58 ? 173 LEU A O      1 
ATOM   2518 C  CB     . LEU A 1 173 ? 318.048 210.537 96.063  1.00 31.82 ? 173 LEU A CB     1 
ATOM   2519 C  CG     . LEU A 1 173 ? 317.361 209.398 95.319  1.00 29.22 ? 173 LEU A CG     1 
ATOM   2520 C  CD1    . LEU A 1 173 ? 316.046 209.123 95.965  1.00 33.29 ? 173 LEU A CD1    1 
ATOM   2521 C  CD2    . LEU A 1 173 ? 317.148 209.723 93.874  1.00 28.23 ? 173 LEU A CD2    1 
ATOM   2522 H  H      . LEU A 1 173 ? 319.993 209.282 96.709  1.00 31.76 ? 173 LEU A H      1 
ATOM   2523 H  HA     . LEU A 1 173 ? 319.570 210.852 94.733  1.00 30.36 ? 173 LEU A HA     1 
ATOM   2524 H  HB2    . LEU A 1 173 ? 318.022 210.314 97.002  1.00 33.01 ? 173 LEU A HB2    1 
ATOM   2525 H  HB3    . LEU A 1 173 ? 317.518 211.327 95.904  1.00 33.72 ? 173 LEU A HB3    1 
ATOM   2526 H  HG     . LEU A 1 173 ? 317.904 208.604 95.379  1.00 29.76 ? 173 LEU A HG     1 
ATOM   2527 H  HD11   . LEU A 1 173 ? 316.191 208.947 96.902  1.00 32.95 ? 173 LEU A HD11   1 
ATOM   2528 H  HD12   . LEU A 1 173 ? 315.642 208.358 95.536  1.00 31.29 ? 173 LEU A HD12   1 
ATOM   2529 H  HD13   . LEU A 1 173 ? 315.484 209.902 95.858  1.00 33.14 ? 173 LEU A HD13   1 
ATOM   2530 H  HD21   . LEU A 1 173 ? 317.998 209.926 93.465  1.00 30.03 ? 173 LEU A HD21   1 
ATOM   2531 H  HD22   . LEU A 1 173 ? 316.556 210.485 93.819  1.00 30.23 ? 173 LEU A HD22   1 
ATOM   2532 H  HD23   . LEU A 1 173 ? 316.742 208.962 93.436  1.00 28.65 ? 173 LEU A HD23   1 
ATOM   2533 N  N      . SER A 1 174 ? 320.417 212.430 97.328  1.00 34.47 ? 174 SER A N      1 
ATOM   2534 C  CA     . SER A 1 174 ? 320.890 213.722 97.798  1.00 37.69 ? 174 SER A CA     1 
ATOM   2535 C  C      . SER A 1 174 ? 321.977 214.324 96.924  1.00 40.20 ? 174 SER A C      1 
ATOM   2536 O  O      . SER A 1 174 ? 322.070 215.550 96.840  1.00 42.89 ? 174 SER A O      1 
ATOM   2537 C  CB     . SER A 1 174 ? 321.423 213.596 99.227  1.00 39.16 ? 174 SER A CB     1 
ATOM   2538 O  OG     . SER A 1 174 ? 322.609 212.828 99.262  1.00 39.16 ? 174 SER A OG     1 
ATOM   2539 H  H      . SER A 1 174 ? 320.557 211.789 97.882  1.00 34.86 ? 174 SER A H      1 
ATOM   2540 H  HA     . SER A 1 174 ? 320.144 214.333 97.812  1.00 37.31 ? 174 SER A HA     1 
ATOM   2541 H  HB2    . SER A 1 174 ? 321.609 214.480 99.570  1.00 39.89 ? 174 SER A HB2    1 
ATOM   2542 H  HB3    . SER A 1 174 ? 320.750 213.160 99.768  1.00 39.02 ? 174 SER A HB3    1 
ATOM   2543 H  HG     . SER A 1 174 ? 322.892 212.780 100.050 1.00 39.80 ? 174 SER A HG     1 
ATOM   2544 N  N      . ASN A 1 175 ? 322.796 213.496 96.277  1.00 39.68 ? 175 ASN A N      1 
ATOM   2545 C  CA     . ASN A 1 175 ? 323.805 214.003 95.362  1.00 36.71 ? 175 ASN A CA     1 
ATOM   2546 C  C      . ASN A 1 175 ? 323.202 214.882 94.279  1.00 40.46 ? 175 ASN A C      1 
ATOM   2547 O  O      . ASN A 1 175 ? 323.851 215.833 93.832  1.00 45.05 ? 175 ASN A O      1 
ATOM   2548 C  CB     . ASN A 1 175 ? 324.548 212.839 94.713  1.00 34.90 ? 175 ASN A CB     1 
ATOM   2549 C  CG     . ASN A 1 175 ? 325.311 212.015 95.703  1.00 37.22 ? 175 ASN A CG     1 
ATOM   2550 O  OD1    . ASN A 1 175 ? 325.006 210.848 95.927  1.00 34.77 ? 175 ASN A OD1    1 
ATOM   2551 N  ND2    . ASN A 1 175 ? 326.326 212.611 96.293  1.00 44.02 ? 175 ASN A ND2    1 
ATOM   2552 H  H      . ASN A 1 175 ? 322.787 212.643 96.353  1.00 38.05 ? 175 ASN A H      1 
ATOM   2553 H  HA     . ASN A 1 175 ? 324.448 214.524 95.856  1.00 37.21 ? 175 ASN A HA     1 
ATOM   2554 H  HB2    . ASN A 1 175 ? 323.916 212.259 94.272  1.00 34.96 ? 175 ASN A HB2    1 
ATOM   2555 H  HB3    . ASN A 1 175 ? 325.186 213.189 94.080  1.00 36.75 ? 175 ASN A HB3    1 
ATOM   2556 H  HD21   . ASN A 1 175 ? 326.501 213.426 96.100  1.00 40.91 ? 175 ASN A HD21   1 
ATOM   2557 H  HD22   . ASN A 1 175 ? 326.803 212.187 96.867  1.00 42.38 ? 175 ASN A HD22   1 
ATOM   2558 N  N      . SER A 1 176 ? 321.977 214.589 93.850  1.00 42.72 ? 176 SER A N      1 
ATOM   2559 C  CA     . SER A 1 176 ? 321.333 215.293 92.751  1.00 43.83 ? 176 SER A CA     1 
ATOM   2560 C  C      . SER A 1 176 ? 320.349 216.340 93.254  1.00 45.01 ? 176 SER A C      1 
ATOM   2561 O  O      . SER A 1 176 ? 319.333 216.610 92.613  1.00 47.36 ? 176 SER A O      1 
ATOM   2562 C  CB     . SER A 1 176 ? 320.628 214.307 91.826  1.00 42.68 ? 176 SER A CB     1 
ATOM   2563 O  OG     . SER A 1 176 ? 321.380 213.118 91.671  1.00 45.40 ? 176 SER A OG     1 
ATOM   2564 H  H      . SER A 1 176 ? 321.492 213.973 94.195  1.00 40.84 ? 176 SER A H      1 
ATOM   2565 H  HA     . SER A 1 176 ? 322.009 215.752 92.234  1.00 43.07 ? 176 SER A HA     1 
ATOM   2566 H  HB2    . SER A 1 176 ? 319.764 214.093 92.205  1.00 41.58 ? 176 SER A HB2    1 
ATOM   2567 H  HB3    . SER A 1 176 ? 320.510 214.723 90.961  1.00 42.13 ? 176 SER A HB3    1 
ATOM   2568 H  HG     . SER A 1 176 ? 321.319 212.653 92.368  1.00 39.72 ? 176 SER A HG     1 
ATOM   2569 N  N      . LEU A 1 177 ? 320.634 216.924 94.410  1.00 47.09 ? 177 LEU A N      1 
ATOM   2570 C  CA     . LEU A 1 177 ? 319.766 217.942 94.972  1.00 51.92 ? 177 LEU A CA     1 
ATOM   2571 C  C      . LEU A 1 177 ? 319.837 219.220 94.145  1.00 62.43 ? 177 LEU A C      1 
ATOM   2572 O  O      . LEU A 1 177 ? 320.835 219.507 93.479  1.00 67.38 ? 177 LEU A O      1 
ATOM   2573 C  CB     . LEU A 1 177 ? 320.162 218.242 96.412  1.00 49.97 ? 177 LEU A CB     1 
ATOM   2574 C  CG     . LEU A 1 177 ? 319.063 218.689 97.369  1.00 52.85 ? 177 LEU A CG     1 
ATOM   2575 C  CD1    . LEU A 1 177 ? 318.032 217.612 97.557  1.00 51.79 ? 177 LEU A CD1    1 
ATOM   2576 C  CD2    . LEU A 1 177 ? 319.675 219.061 98.692  1.00 51.83 ? 177 LEU A CD2    1 
ATOM   2577 H  H      . LEU A 1 177 ? 321.321 216.741 94.888  1.00 46.15 ? 177 LEU A H      1 
ATOM   2578 H  HA     . LEU A 1 177 ? 318.853 217.626 94.957  1.00 50.28 ? 177 LEU A HA     1 
ATOM   2579 H  HB2    . LEU A 1 177 ? 320.552 217.443 96.792  1.00 48.59 ? 177 LEU A HB2    1 
ATOM   2580 H  HB3    . LEU A 1 177 ? 320.826 218.946 96.390  1.00 50.11 ? 177 LEU A HB3    1 
ATOM   2581 H  HG     . LEU A 1 177 ? 318.619 219.468 97.010  1.00 53.08 ? 177 LEU A HG     1 
ATOM   2582 H  HD11   . LEU A 1 177 ? 317.629 217.403 96.702  1.00 50.88 ? 177 LEU A HD11   1 
ATOM   2583 H  HD12   . LEU A 1 177 ? 317.358 217.938 98.169  1.00 51.84 ? 177 LEU A HD12   1 
ATOM   2584 H  HD13   . LEU A 1 177 ? 318.463 216.828 97.924  1.00 48.92 ? 177 LEU A HD13   1 
ATOM   2585 H  HD21   . LEU A 1 177 ? 320.128 218.284 99.050  1.00 49.94 ? 177 LEU A HD21   1 
ATOM   2586 H  HD22   . LEU A 1 177 ? 318.969 219.341 99.291  1.00 51.88 ? 177 LEU A HD22   1 
ATOM   2587 H  HD23   . LEU A 1 177 ? 320.308 219.782 98.559  1.00 51.79 ? 177 LEU A HD23   1 
ATOM   2588 N  N      . LYS A 1 178 ? 318.760 219.998 94.216  1.00 66.35 ? 178 LYS A N      1 
ATOM   2589 C  CA     . LYS A 1 178 ? 318.632 221.258 93.486  1.00 67.15 ? 178 LYS A CA     1 
ATOM   2590 C  C      . LYS A 1 178 ? 319.132 221.136 92.052  1.00 70.75 ? 178 LYS A C      1 
ATOM   2591 O  O      . LYS A 1 178 ? 319.512 222.125 91.428  1.00 67.73 ? 178 LYS A O      1 
ATOM   2592 C  CB     . LYS A 1 178 ? 319.381 222.382 94.209  1.00 67.13 ? 178 LYS A CB     1 
ATOM   2593 C  CG     . LYS A 1 178 ? 320.880 222.180 94.325  1.00 67.82 ? 178 LYS A CG     1 
ATOM   2594 C  CD     . LYS A 1 178 ? 321.563 223.386 94.936  1.00 67.97 ? 178 LYS A CD     1 
ATOM   2595 C  CE     . LYS A 1 178 ? 321.216 223.543 96.404  1.00 66.67 ? 178 LYS A CE     1 
ATOM   2596 N  NZ     . LYS A 1 178 ? 321.907 224.711 97.014  1.00 70.49 ? 178 LYS A NZ     1 
ATOM   2597 H  H      . LYS A 1 178 ? 318.073 219.811 94.697  1.00 61.92 ? 178 LYS A H      1 
ATOM   2598 H  HA     . LYS A 1 178 ? 317.696 221.508 93.454  1.00 66.29 ? 178 LYS A HA     1 
ATOM   2599 H  HB2    . LYS A 1 178 ? 319.238 223.208 93.726  1.00 67.26 ? 178 LYS A HB2    1 
ATOM   2600 H  HB3    . LYS A 1 178 ? 319.025 222.460 95.104  1.00 65.91 ? 178 LYS A HB3    1 
ATOM   2601 H  HG2    . LYS A 1 178 ? 321.054 221.422 94.903  1.00 65.11 ? 178 LYS A HG2    1 
ATOM   2602 H  HG3    . LYS A 1 178 ? 321.254 222.029 93.445  1.00 66.99 ? 178 LYS A HG3    1 
ATOM   2603 H  HD2    . LYS A 1 178 ? 322.524 223.279 94.863  1.00 67.48 ? 178 LYS A HD2    1 
ATOM   2604 H  HD3    . LYS A 1 178 ? 321.277 224.185 94.468  1.00 67.69 ? 178 LYS A HD3    1 
ATOM   2605 H  HE2    . LYS A 1 178 ? 320.261 223.673 96.497  1.00 66.19 ? 178 LYS A HE2    1 
ATOM   2606 H  HE3    . LYS A 1 178 ? 321.495 222.747 96.881  1.00 64.87 ? 178 LYS A HE3    1 
ATOM   2607 H  HZ1    . LYS A 1 178 ? 321.725 225.447 96.548  1.00 69.04 ? 178 LYS A HZ1    1 
ATOM   2608 H  HZ2    . LYS A 1 178 ? 321.630 224.824 97.853  1.00 69.90 ? 178 LYS A HZ2    1 
ATOM   2609 H  HZ3    . LYS A 1 178 ? 322.786 224.577 97.013  1.00 69.17 ? 178 LYS A HZ3    1 
HETATM 2610 MG MG     . MG  B 2 .   ? 301.917 198.953 96.111  1.00 30.92 ? 201 MG  A MG     1 
HETATM 2611 P  PG     . GSP C 3 .   ? 301.392 196.337 94.009  1.00 38.36 ? 202 GSP A PG     1 
HETATM 2612 O  O3B    . GSP C 3 .   ? 303.024 196.408 93.972  1.00 36.65 ? 202 GSP A O3B    1 
HETATM 2613 S  S1G    . GSP C 3 .   ? 300.810 194.594 94.431  1.00 61.97 ? 202 GSP A S1G    1 
HETATM 2614 O  O2G    . GSP C 3 .   ? 300.878 197.388 95.067  1.00 47.37 ? 202 GSP A O2G    1 
HETATM 2615 O  O3G    . GSP C 3 .   ? 300.824 196.734 92.606  1.00 28.09 ? 202 GSP A O3G    1 
HETATM 2616 P  PB     . GSP C 3 .   ? 303.899 196.610 95.351  1.00 36.76 ? 202 GSP A PB     1 
HETATM 2617 O  O1B    . GSP C 3 .   ? 305.261 197.038 95.029  1.00 37.88 ? 202 GSP A O1B    1 
HETATM 2618 O  O2B    . GSP C 3 .   ? 303.228 197.638 96.184  1.00 44.66 ? 202 GSP A O2B    1 
HETATM 2619 P  PA     . GSP C 3 .   ? 304.107 195.039 97.815  1.00 41.33 ? 202 GSP A PA     1 
HETATM 2620 O  O1A    . GSP C 3 .   ? 304.758 196.329 98.385  1.00 35.97 ? 202 GSP A O1A    1 
HETATM 2621 O  O2A    . GSP C 3 .   ? 302.707 194.857 98.442  1.00 40.66 ? 202 GSP A O2A    1 
HETATM 2622 O  O3A    . GSP C 3 .   ? 303.947 195.179 96.163  1.00 36.68 ? 202 GSP A O3A    1 
HETATM 2623 O  "O5'"  . GSP C 3 .   ? 305.066 193.714 98.168  1.00 41.86 ? 202 GSP A "O5'"  1 
HETATM 2624 C  "C5'"  . GSP C 3 .   ? 304.615 192.440 97.715  1.00 37.31 ? 202 GSP A "C5'"  1 
HETATM 2625 C  "C4'"  . GSP C 3 .   ? 304.862 191.381 98.746  1.00 37.06 ? 202 GSP A "C4'"  1 
HETATM 2626 O  "O4'"  . GSP C 3 .   ? 306.455 191.072 98.868  1.00 42.84 ? 202 GSP A "O4'"  1 
HETATM 2627 C  "C3'"  . GSP C 3 .   ? 304.451 191.799 99.906  1.00 35.73 ? 202 GSP A "C3'"  1 
HETATM 2628 O  "O3'"  . GSP C 3 .   ? 303.832 190.678 100.639 1.00 39.45 ? 202 GSP A "O3'"  1 
HETATM 2629 C  "C2'"  . GSP C 3 .   ? 305.716 192.287 100.633 1.00 35.57 ? 202 GSP A "C2'"  1 
HETATM 2630 O  "O2'"  . GSP C 3 .   ? 305.580 192.137 101.981 1.00 38.42 ? 202 GSP A "O2'"  1 
HETATM 2631 C  "C1'"  . GSP C 3 .   ? 306.833 191.382 100.077 1.00 36.71 ? 202 GSP A "C1'"  1 
HETATM 2632 N  N9     . GSP C 3 .   ? 308.154 192.095 100.041 1.00 35.36 ? 202 GSP A N9     1 
HETATM 2633 C  C8     . GSP C 3 .   ? 308.715 193.287 99.760  1.00 33.00 ? 202 GSP A C8     1 
HETATM 2634 N  N7     . GSP C 3 .   ? 310.037 193.168 99.974  1.00 32.37 ? 202 GSP A N7     1 
HETATM 2635 C  C5     . GSP C 3 .   ? 310.277 191.926 100.379 1.00 32.95 ? 202 GSP A C5     1 
HETATM 2636 C  C6     . GSP C 3 .   ? 311.578 191.217 100.766 1.00 35.83 ? 202 GSP A C6     1 
HETATM 2637 O  O6     . GSP C 3 .   ? 312.622 191.821 100.726 1.00 36.24 ? 202 GSP A O6     1 
HETATM 2638 N  N1     . GSP C 3 .   ? 311.561 189.842 101.175 1.00 43.82 ? 202 GSP A N1     1 
HETATM 2639 C  C2     . GSP C 3 .   ? 310.302 189.140 101.214 1.00 45.71 ? 202 GSP A C2     1 
HETATM 2640 N  N2     . GSP C 3 .   ? 310.236 187.756 101.621 1.00 49.87 ? 202 GSP A N2     1 
HETATM 2641 N  N3     . GSP C 3 .   ? 309.069 189.825 100.842 1.00 40.12 ? 202 GSP A N3     1 
HETATM 2642 C  C4     . GSP C 3 .   ? 309.093 191.249 100.421 1.00 35.80 ? 202 GSP A C4     1 
HETATM 2643 H  HOG2   . GSP C 3 .   ? 300.639 198.160 94.631  1.00 40.87 ? 202 GSP A HOG2   1 
HETATM 2644 H  HOG3   . GSP C 3 .   ? 301.415 197.378 92.251  1.00 34.36 ? 202 GSP A HOG3   1 
HETATM 2645 H  "H5'1" . GSP C 3 .   ? 303.584 192.499 97.523  1.00 38.45 ? 202 GSP A "H5'1" 1 
HETATM 2646 H  "H5'2" . GSP C 3 .   ? 305.123 192.177 96.826  1.00 36.25 ? 202 GSP A "H5'2" 1 
HETATM 2647 H  "H4'"  . GSP C 3 .   ? 304.305 190.438 98.477  1.00 38.39 ? 202 GSP A "H4'"  1 
HETATM 2648 H  "H3'"  . GSP C 3 .   ? 303.742 192.610 99.780  1.00 37.32 ? 202 GSP A "H3'"  1 
HETATM 2649 H  "HO3'" . GSP C 3 .   ? 302.879 190.735 100.552 1.00 38.72 ? 202 GSP A "HO3'" 1 
HETATM 2650 H  "H2'"  . GSP C 3 .   ? 305.935 193.371 100.368 1.00 36.34 ? 202 GSP A "H2'"  1 
HETATM 2651 H  "HO2'" . GSP C 3 .   ? 305.171 192.961 102.364 1.00 37.08 ? 202 GSP A "HO2'" 1 
HETATM 2652 H  "H1'"  . GSP C 3 .   ? 306.861 190.455 100.712 1.00 37.59 ? 202 GSP A "H1'"  1 
HETATM 2653 H  H8     . GSP C 3 .   ? 308.208 194.168 99.426  1.00 33.46 ? 202 GSP A H8     1 
HETATM 2654 H  HN21   . GSP C 3 .   ? 309.349 187.287 101.636 1.00 46.50 ? 202 GSP A HN21   1 
HETATM 2655 H  HN22   . GSP C 3 .   ? 311.070 187.267 101.885 1.00 46.89 ? 202 GSP A HN22   1 
HETATM 2656 O  O      . HOH D 4 .   ? 302.442 200.490 95.054  1.00 13.38 ? 301 HOH A O      1 
HETATM 2657 O  O      . HOH D 4 .   ? 301.161 197.563 97.382  1.00 14.14 ? 302 HOH A O      1 
# 
